bluuebunny/crossref_metadata_2025_split huggingface dataset:
Masking of macular neovascular membranes by subretinal hyperreflective material on optical coherence tomography angiography
Authors: Fayed Alaa E. , Baddar Dina , Estawro Rania G. , Gerges Terese K. 
Published: March 2022

Purpose The purpose of this study was to determine whether subretinal hyperreflective material (SHRM) may mask the detection of macular neovascular membranes (MNV) on optical coherence tomography angiography (OCTA). Methods In this observational study, eyes with active neovascular age-related macular degeneration (nAMD), co-existing SHRM & intraretinal or subretinal fluid or hemorrhage on structural OCT, underwent OCTA & fundus fluorescein angiography (FFA) imaging. 6 × 6 mm choriocapillaris and outer retinal slabs on OCTA were examined to determine the presence of MNV underneath the SHRM. The corresponding area on FFA was used as a reference arm to confirm activity. Results Thirty eyes of thirty patients with SHRM and active nAMD were recruited. All eyes failed to show a MNV in the choriocapillaris & avascular slabs of the OCTA underneath the SHRM, but showed active hyperfluorescent MNVs that increased in size and intensity in the late stages of FFA. In one eye, parts of a MNV under the SHRM were undetectable due to signal attenuation, while parts extending beyond the SHRM were detected on the choriocapillaris en face slab with flow on the B scan. Conclusions SHRM may act as a reflecting surface that limits the passage of light waves in OCTA, creating areas of signal attenuation and diminishing its ability to detect underlying MNVs.
Evaluation of the impact of childhood obesity on retrobulbar hemodynamics and retinal microvasculature
Authors: Celik Gokhan , Gunay Murat , Ozcabi Bahar , Gulturk Ulas , Kizilay Osman , Vural Asli , Ozkul Saglam Neslihan , Papatya Cakir Esra Deniz , Palabiyik Figen , Onal Gunay Betul , Yigit Fadime Ulviye 
Published: March 2022

Objective To evaluate changes in retrobulbar ocular blood flow parameters by using Colour Doppler Imaging (CDI) and changes in foveal microvasculature by using Optical Coherence Tomography Angiography (OCTA) in pediatric obese patients and to compare them with a group of healthy children. Methods Children diagnosed with obesity without hypertension and diabetes (39 subjects, obese group) and age-matched healthy controls (26 subjects, control group) underwent CDI and OCTA imaging. Peak systolic velocity, end-diastolic velocity and resistivity index from ophthalmic, central retinal and posterior ciliary arteries on CDI; superficial and deep capillary plexus vascular density and foveal avascular zone area on OCTA imaging were obtained in each group. Central foveal and subfoveal choroidal thicknesses were also measured. CDI and OCTA parameters were compared between two groups. Results Peak systolic and end-diastolic velocities were found to be significantly lower in obese children than in controls in all three examined arteries (p < 0.05). Resistivity index values were similar between the groups. OCTA imaging did not reveal significant changes in superficial and deep capillary plexus vascular densities and foveal avascular zone area across analysed retinal regions between the groups. Subfoveal choroid was thicker in obese group than in control group (325.89 ± 52.77 µm vs. 304.52 ± 21.76 µm, p = 0.04). Conclusion An apparent decrease was present in retrobulbar hemodynamics in obese children. This arises the possibility of early ocular macrovascular compromise rather than retinal microvascular impairment in childhood obesity.
Pregnancy in juvenile idiopathic arthritis: maternal and foetal outcome, and impact on disease activity
Authors: Gerosa Maria , Chighizola Cecilia Beatrice , Pregnolato Francesca , Pontikaki Irene , Luppino Angela Flavia , Argolini Lorenza Maria , Trespidi Laura , Ossola Manuela Wally , Ferrazzi Enrico M. , Caporali Roberto , Cimaz Rolando 
Published: March 2022

Objective: This retrospective cohort study describes the modulation of disease activity during gestation and in the year following delivery as well as maternal and neonatal outcomes in a monocentric cohort of women with juvenile idiopathic arthritis (JIA). Methods: Disease activity was assessed using DAS28-CRP before conception and every 3 months during pregnancy and in the first year postpartum. The risk of complicated pregnancies was measured applying a generalized estimating equation model. Changes in disease activity during gestation and in the first year postpartum were assessed in a linear mixed model for repeated measures. Results: Thirty-one women (49 pregnancies) with persisting JIA and at least one conception were enrolled. Adjusted DAS28-CRP levels remained stable from preconception through the first trimester, but increased significantly in the second and decreased not significantly in the third. In the postpartum, adjusted disease activity peaked at 3 months after delivery, stabilized at 6 months to decrease at 1 year, although not significantly. Preconceptional DAS28-CRP and number of biological drugs predicted disease activity fluctuation during gestation. The number of biological drugs and the length of gestational exposure to biologics significantly predicted pregnancy morbidity. In particular, JIA women had a higher probability of preterm delivery compared with healthy and disease controls. Adjusted for breastfeeding and DAS28-CRP score in the third trimester, postconceptional exposure to biologics was inversely related with disease activity in the postpartum: the longer the patient continued treatment, the lower the probability of experiencing an adverse pregnancy outcome. Conclusion: These data offer novel insights on how treatment affects disease activity during pregnancy and postpartum as well as obstetric outcomes in women with JIA.
Barriers and Enablers to Early Identification, Referral and Access to Geriatric Rehabilitation Post-Hip Fracture: A Theory-Based Descriptive Qualitative Study
Authors: Backman Chantal , Harley Anne , Papp Steve , French-Merkley Veronique , Beaulé Paul E , Poitras Stéphane , Dobransky Johanna , Squires Janet E 
Published: March 2022

Background Geriatric hip fracture patients often experience gaps in care including variability in the timing and the choice of an appropriate setting for rehabilitation following hip fracture surgery. Many guidelines recommend standardized processes, including timely access of no later than day 6 to rehabilitation services. A pathway for early identification, referral and access to geriatric rehabilitation post-hip fracture was created to facilitate the implementation. The study aimed to describe the barriers and enablers prior to the implementation of this pathway. Methods We conducted a qualitative descriptive study consisting of semi-structured interviews with geriatric hip fracture patients (n = 8), caregivers (n = 1), administrators (n = 12) and clinicians (n = 17) in 2 orthopaedics units and a geriatric rehabilitation service. Responses were analysed using a systematic approach, and overarching themes describing the barriers and enablers were identified. Results The clinicians’ and administrators’ top barriers to implementation of the pathway were competing demands (n = 24); lack of bed availability, community resources and funding (n = 19); and the need for extended hours and increased staff (n = 16). The top 3 enablers were clear communication with patients (n = 27), awareness of the benefits of geriatric rehabilitation (n = 24) and the need for education and resources to properly use the pathway (n = 15). Common barriers among patients and caregivers included lack of care coordination, overcoming some of their own specific challenges during their transition, gaps in the information they received before discharge, not knowing what questions to ask and lack of resources. Despite these barriers, patients were generally pleased with their transition from the hospital to geriatric rehabilitation. Conclusion We identified and described key barriers and enablers to early identification, referral and access to geriatric rehabilitation post-hip fracture. These influencing factors provide a basis for the development of a standardized pathway aimed at improving access to rehabilitative care for geriatric hip fracture patients.
Frailty in Elderly Patients with Covid-19: A Narrative Review
Authors: Salini Sara , Russo Andrea , De Matteis Giuseppe , Piccioni Andrea , Della Polla Davide , Carbone Luigi , Barillaro Christian , Landi Francesco , Franceschi Francesco , Covino Marcello 
Published: March 2022

Introduction The SARS CoV-2 pandemic still generates a very high number of affected patients and a significant mortality rate. It is essential to establish objective criteria to stratify COVID-19 death risk. Frailty has been identified as a potential determinant of increased vulnerability in older adults affected by COVID-19, because it may suggest alterations of physical performance and functional autonomy. Methods We have conducted a narrative review of the literature on the evidences regarding COVID-19 and the frailty condition. Thirteen observational studies were included. Conclusion Data emerging from the studies indicate that older COVID-19 patients with a frailty condition have an increased risk of mortality compared with non-frail patients, and this association is independent of other clinical and demographic factors. A frailty evaluation is required to help clinicians to better stratify the overall risk of death for older patients with COVID-19.
Trade Policy Impact on Global Value Chain Participation of the South Asian Countries
Authors: Wijesinghe Asanka , Yogarajah Chathurrdhika 
Published: March 2022

This article provides an empirical analysis on the relationship between trade policy and global value chain (GVC) participation of the South Asian countries using Asian Development Bank’s country-sector Wang, Wei and Zhu decomposed exports data. We employ theoretically grounded three-way fixed effects gravity model with bias correction for incidental parameter problem to get unbiased and consistent coefficients for trade policy variables. This study finds strong evidence for the depressing effect of border tariffs on bilateral exports and forward and backward GVC participation. The negative effects are most prominent in the agriculture and food sectors. Moreover, we find that the regional trade agreements (RTAs) of South Asian countries have a negligible impact on trade and GVC participation in most sectors. However, we find evidence for the phasing-in effect of RTAs and a strong negative effect on bilateral food trade and GVC participation. Reformulating trade policy priorities and restructuring the RTAs to remove strict general regulatory measures like sensitive lists and rules of origin (ROO) should be South Asian policymakers’ priorities for robust trade lead growth. JEL Classification: F14, L23, O11, O55, Q17
Reznitskyite, CaMg(VO4)F, a new mineral from the Tolbachik volcano, Kamchatka, Russia and the first vanadate with a titanite-type structure
Authors: Koshlyakova Natalia N. , Pekov Igor V. , Vigasina Marina F. , Zubkova Natalia V. , Agakhanov Atali A. , Britvin Sergey N. , Sidorov Evgeny G. , Pushcharovsky Dmitry Yu. 
Published: March 2022

AbstractReznitskyite, ideally CaMg(VO4)F, is a new mineral species of the tilasite group from the Arsenatnaya fumarole, Northern Breakthrough of the Great Tolbachik Fissure Eruption, Tolbachik volcano, Kamchatka, Russia. It occurs as zones (usually up to 0.05 mm thick) in crystals of V- and P-containing tilasite or as homogeneous grains up to 0.1 mm across. It was found in polymineralic sublimate encrustations in association with minerals of the svabite–fluorapatite–pliniusite system and the schäferite–berzeliite, tilasite–isokite, wagnerite–arsenowagnerite and udinaite–arsenudinaite series. The mineral assemblage also includes calciojohillerite, diopside, forsterite, titanite, rhabdoborite-(V), rhabdoborite-(W), rhabdoborite-(Mo), ludwigite, powellite, scheelite, hematite, baryte and magnesioferrite. Reznitskyite is transparent or semi-transparent, colourless, with vitreous lustre.Dcalc.= 3.453 g cm–3. Under the microscope, in reflected light reznitskyite is grey, non-pleochroic, with very weak bireflectance (ΔR589 nm= 0.5%) and distinct anisotropy. Reznitskyite is the first vanadate with a titanite-type structure. It is monoclinic, space groupC2/c,a= 6.6912(7),b= 8.9395(7),c= 7.0587(8) Å, β = 113.078(13)°,V= 388.43(8) Å3andZ= 4. The strongest reflections of the powder X-ray diffraction pattern are [din Å(I)(hkl)]: 3.082(100)(200), 3.250(66)($\bar{1}$12, 002), 2.631(44)(022), 2.854(34)($\bar{2}$02), 2.683(33)(130), 3.686(26)(021), 2.531(25)(220), 1.749(25)($\bar{3}$32,$\bar{2}$04) and 2.344(24)(131). Electron microprobe analysis gave (wt.%) MgO 20.44, CaO 26.83, P2O56.24, V2O521.09, As2O518.97, SO30.47, F 9.42, –O=F –3.97, with a total of 99.49. The empirical formula of reznitskyite, calculated on the basis of O+F = 5 atoms per formula unit, is: Ca0.97Mg1.03(V0.47As0.33P0.18S0.01)Σ0.99O3.99F1.01. Reznitskyite is a vanadate analogue of tilasite CaMg(AsO4)F and isokite CaMg(PO4)F. The mineral is named in honour of the outstanding Russian mineralogist Leonid Zinovievich Reznitsky (born 1938) who has made significant contribution to the mineralogy of vanadium.
Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis
Authors: Yang Yiqing , Mumau Melanie , Tober Joanna , Zhu Qin , Bennett Laura , Hong Courtney , Sung Derek , Keller Thomas , Uzun Yasin , Gao Peng , Shewale Swapnil , Chen Mei , Yang Jisheng , Chen Xiaowen , Thomas Steven A. , Tan Kai , Speck Nancy A. , Kahn Mark L. 
Published: March 2022

Abstract
The hematopoietic stem cells (HSCs) that produce blood for the lifetime of an animal arise from RUNX1+ hemogenic endothelial cells (HECs) in the embryonic vasculature through a process of endothelial-to-hematopoietic transition (EHT). Studies have identified inflammatory mediators and fluid shear forces as critical environmental stimuli for EHT, raising the question of how such diverse inputs are integrated to drive HEC specification. Endothelial cell MEKK3-KLF2/4 signaling can be activated by both fluid shear forces and inflammatory mediators, and it plays roles in cardiovascular development and disease that have been linked to both stimuli. Here we demonstrate that MEKK3 and KLF2/4 are required in endothelial cells for the specification of RUNX1+ HECs in both the yolk sac and dorsal aorta of the mouse embryo and for their transition to intraaortic hematopoietic cluster (IAHC) cells. The inflammatory mediators lipopolysaccharide and interferon-γ increase RUNX1+ HECs in an MEKK3-dependent manner. Maternal administration of catecholamines that stimulate embryo cardiac function and accelerate yolk sac vascular remodeling increases EHT by wild-type but not MEKK3-deficient endothelium. These findings identify MEKK-KLF2/4 signaling as an essential pathway for EHT and provide a molecular basis for the integration of diverse environmental inputs, such as inflammatory mediators and hemodynamic forces, during definitive hematopoiesis.
Outcome of donor-derived TAA-T cell therapy in patients with high-risk or relapsed acute leukemia post allogeneic BMT
Authors: Kinoshita Hannah , Cooke Kenneth R. , Grant Melanie , Stanojevic Maja , Cruz C. Russell , Keller Michael , Fortiz Maria Fernanda , Hoq Fahmida , Lang Haili , Barrett A. John , Liang Hua , Tanna Jay , Zhang Nan , Shibli Abeer , Datar Anushree , Fulton Kenneth , Kukadiya Divyesh , Zhang Anqing , Williams Kirsten M. , Dave Hema , Dome Jeffrey S. , Jacobsohn David , Hanley Patrick J. , Jones Richard J. , Bollard Catherine M. 
Published: March 2022

AbstractPatients with hematologic malignancies relapsing after allogeneic blood or marrow transplantation (BMT) have limited response to conventional salvage therapies, with an expected 1-year overall survival (OS) of &lt;20%. We evaluated the safety and clinical outcomes following administration of a novel T-cell therapeutic targeting 3 tumor-associated antigens (TAA-T) in patients with acute leukemia who relapsed or were at high risk of relapse after allogeneic BMT. Lymphocytes obtained from the BMT donor were manufactured to target TAAs WT1, PRAME, and survivin, which are over-expressed and immunogenic in most hematologic malignancies. Patients received TAA-T infusions at doses of 0.5 to 4 × 107/m2. Twenty-three BMT recipients with relapsed/refractory (n = 11) and/or high-risk (n = 12) acute myeloid leukemia (n = 20) and acute lymphoblastic leukemia (n = 3) were infused posttransplant. No patient developed cytokine-release syndrome or neurotoxicity, and only 1 patient developed grade 3 graft-versus-host disease. Of the patients who relapsed post-BMT and received bridging therapy, the majority (n = 9/11) achieved complete hematologic remission before receiving TAA-T. Relapsed patients exhibited a 1-year OS of 36% and 1-year leukemia-free survival of 27.3% post–TAA-T. The poorest prognosis patients (relapsed &lt;6 months after transplant) exhibited a 1-year OS of 42.8% postrelapse (n = 7). Median survival was not reached for high-risk patients who received preemptive TAA-T posttransplant (n = 12). Although as a phase 1 study, concomitant antileukemic therapy was allowed, TAA-T were safe and well tolerated, and sustained remissions in high-risk and relapsed patients were observed. Moreover, adoptively transferred TAA-T detected by T-cell receptor V-β sequencing persisted up to at least 1 year postinfusion. This trial was registered at clinicaltrials.gov as #NCT02203903.
High-throughput sequencing data revealed genotype-specific changes evoked by heat stress in crown tissue of barley sdw1 near-isogenic lines
Authors: Mikołajczak Krzysztof , Kuczyńska Anetta , Ogrodowicz Piotr , Kiełbowicz-Matuk Agnieszka , Ćwiek-Kupczyńska Hanna , Daszkowska-Golec Agata , Szarejko Iwona , Surma Maria , Krajewski Paweł 
Published: March 2022

Abstract
Background
High temperature shock is becoming increasingly common in our climate, affecting plant growth and productivity. The ability of a plant to survive stress is a complex phenomenon. One of the essential tissues for plant performance under various environmental stimuli is the crown. However, the molecular characterization of this region remains poorly investigated. Gibberellins play a fundamental role in whole-plant stature formation. This study identified plant stature modifications and crown-specific transcriptome re-modeling in gibberellin-deficient barley sdw1.a (BW827) and sdw1.d (BW828) mutants exposed to increased temperature.

Results
The deletion around the sdw1 gene in BW827 was found to encompass at least 13 genes with primarily regulatory functions. A bigger genetic polymorphism of BW828 than of BW827 in relation to wild type was revealed. Transcriptome-wide sequencing (RNA-seq) revealed several differentially expressed genes involved in gibberellin metabolism and heat response located outside of introgression regions. It was found that HvGA20ox4, a paralogue of the HvGA20ox2 gene, was upregulated in BW828 relative to other genotypes, which manifested as basal internode elongation. The transcriptome response to elevated temperature differed in the crown of sdw1.a and sdw1.d mutants; it was most contrasting for HvHsf genes upregulated under elevated temperature in BW828, whereas those specific to BW827 were downregulated. In-depth examination of sdw1 mutants revealed also some differences in their phenotypes and physiology.

Conclusions
We concluded that despite the studied sdw1 mutants being genetically related, their heat response seemed to be genotype-specific and observed differences resulted from genetic background diversity rather than single gene mutation, multiple gene deletion, or allele-specific expression of the HvGA20ox2 gene. Differences in the expressional reaction of genes to heat in different sdw1 mutants, found to be independent of the polymorphism, could be further explained by in-depth studies of the regulatory factors acting in the studied system. Our findings are particularly important in genetic research area since molecular response of crown tissue has been marginally investigated, and can be useful for wide genetic research of crops since barley has become a model plant for them.
Influence of cardiopulmonary exercise test on platelet function in patients with coronary artery diseases on antiplatelet therapy
Authors: Yin Chun , Wang Yanhui , Mo Chunhua , Yue Zong , Sun Yihong , Hu Dayi 
Published: March 2022

Abstract
Background
Cardiac rehabilitation reduces mortality and morbidity rate of patients with coronary artery diseases (CAD); however, acute exercise stimulation may also increase the thrombotic risk through platelet activation. Studies on the effects of cardiac rehabilitation on platelet function have been sparse.

Methods
A total of 28 patients (24 men and 4 women; average age = 54.6 ± 8 years old) with stable CAD were enrolled in this study and divided into Aspirin-treated (n = 11; Aspirin group) and dual-antiplatelet-treated group (DAPT group; n = 17). Symptom-limited cardiopulmonary exercise test (CPET) with a cycle ergometer was performed on all the patients. Before and after CPET, platelet function was evaluated using light transmission aggregometry and whole blood flow cytometry.

Results
All patients completed the CPET without provoked cardiac events, and the mean value of peak oxygen uptake (Peak Vo2) was 19.3 ± 3 ml/(kg min). Prior to CPET, platelet aggregation was significantly suppressed in DAPT group compared to Aspirin group (43.0 ± 21.5 vs. 72.9 ± 7.5, p < 0.001). CPET promoted platelet aggregation in Aspirin group (72.9 ± 7.5 vs. 80.9 ± 7.6, p = 0.005) and DAPT group (43.0 ± 21.5 vs. 50.1 ± 20.9, p = 0.010), and platelet count was increased in Aspirin (210.9 ± 54.6 vs. 227.5 ± 58.1, p = 0.001) and DAPT group (217.5 ± 63.8 vs. 229.7 ± 63.7, p = 0.001). However, the expression levels of CD62p and PAC-1 were not affected by CPET in both groups.

Conclusion
Symptom-limited CPET enhanced platelet aggregation in patients with CAD despite treatment with antiplatelet, mainly via platelet count augmentation, but not through single platelet activation.
Trial registration: Effects of high intensity interval training versus moderate intensity continue training in cardiac rehabilitation on platelet function of patients with coronary heart diseases: a exploratory randomized controlled trial.
ChiCTR-INR-17010717. Registered 23 February 2017, https://www.chictr.org.cn/edit.aspx?pid=18206&htm=4.