bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene signature of circulating platelet‐bound neutrophils is associated with poor prognosis in cancer patients
Authors: Lecot Pacôme , Ardin Maude , Dussurgey Sébastien , Alcazer Vincent , Moudombi Lyvia , Pereira Abrantes Manuela , Hubert Margaux , Swalduz Aurélie , Hernandez‐Vargas Hector , Viari Alain , Caux Christophe , Michallet Marie‐Cécile 
Published: March 2022

AbstractBeyond their critical role in hemostasis, platelets physically interact with neutrophils to form neutrophil‐platelet aggregates (NPAs), enhancing neutrophil effector functions during inflammation. NPAs may also promote disease worsening in various inflammatory diseases. However, characterization of NPAs in cancer remains totally unexplored. Using ImageStreamX (ISX) imaging flow cytometer, we were not only allowed able to detect CD15+ CD14− CD36+ ITGA2B+ NPAs in both healthy donors' (HDs) and cancer patients' bloods, but we also showed that NPAs result from the binding of platelets preferentially to low‐density neutrophils (LDNs) as opposed to normal‐density neutrophils (NDNs). By reanalyzing two independent public scRNAseq data of whole blood leukocytes from cancer patients and HDs, we could identify a subset of neutrophils with high platelet gene expression that may correspond to NPAs. Moreover, we showed that cancer patients' derived NPAs possessed a distinct molecular signature compared to the other neutrophil subsets, independently of platelet genes. Gene ontology (GO) term enrichment analysis of this NPAs‐associated neutrophil transcriptomic signature revealed a significant enrichment of neutrophil degranulation, chemotaxis and trans‐endothelial migration GO terms. Lastly, using The Cancer Genome Atlas (TCGA), we could show by multivariate Cox analysis that the NPAs‐associated neutrophil transcriptomic signature was associated with a worse patient prognosis in several cancer types. These results suggest that neutrophils from NPAs are systemically primed by platelets empowering them with cancer progression capacities once at tumor site. NPAs may therefore hold clinical utility as novel noninvasive blood prognostic biomarker in cancer patients with solid tumors.
Parallel‐Meta Suite: Interactive and rapid microbiome data analysis on multiple platforms
Authors: Chen Yuzhu , Li Jian , Zhang Yufeng , Zhang Mingqian , Sun Zheng , Jing Gongchao , Huang Shi , Su Xiaoquan 
Published: March 2022

AbstractMassive microbiome sequencing data has been generated, which elucidates associations between microbes and their environmental phenotypes such as host health or ecosystem status. Outstanding bioinformatic tools are the basis to decipher the biological information hidden under microbiome data. However, most approaches placed difficulties on the accessibility to nonprofessional users. On the other side, the computing throughput has become a significant bottleneck of many analytical pipelines in processing large‐scale datasets. In this study, we introduce Parallel‐Meta Suite (PMS), an interactive software package for fast and comprehensive microbiome data analysis, visualization, and interpretation. It covers a wide array of functions for data preprocessing, statistics, visualization by state‐of‐the‐art algorithms in a user‐friendly graphical interface, which is accessible to diverse users. To meet the rapidly increasing computational demands, the entire procedure of PMS has been optimized by a parallel computing scheme, enabling the rapid processing of thousands of samples. PMS is compatible with multiple platforms, and an installer has been integrated for full‐automatic installation.
Inside Cover
Authors: Zhou Shun , Li Jiaji , Sun Jiasong , Zhou Ning , Chen Qian , Zuo Chao 
Published: March 2022

Based on a bright‐field microscope with a programmable LED array light source, accelerated Fourier ptychographic diffraction tomography (aFPDT) technique employing a hybrid strategy of sparse annular and multiplexing illuminations was developed to achieve large field‐of‐view and high‐resolution 3D RI tomographic imaging. Compared with previous work, aFPDT enables the reducing of intensity data requirement by more than 40 times and to achieve computational acceleration of 3D tomographic reconstruction. aFPDT has the potential to advance its widespread applications in biomedicine.Further details can be found in the article by Shun Zhou, Jiaji Li, Jiasong Sun, Ning Zhou, Qian Chen, and Chao Zuo (e202100272).image
Wellness integration in professional counseling: A grounded theory
Authors: Long Susan M. , Clark Madeline , Reed Leah , Raghavan Ellise 
Published: March 2022

AbstractWellness is a central component of professional counseling. It is important that counselors are aware of and integrate wellness‐based strategies that support and optimize client's holistic well‐being. To date, there are no existing frameworks to guide the processes of wellness integration in counseling. The present study aimed to identify the specific processes and strategies used by 21 professional counselors who integrate wellness into clinical practice. Five main themes were identified: (a) assessment of wellness, (b) skills, (c), interventions, (d) barriers, and (e) advocacy.
Stigma, help‐seeking, and counseling with African American male college students
Authors: Shannon Jordan , Seward Derek X. , Liu Yanhong , Luke Melissa 
Published: March 2022

AbstractThe help‐seeking processes of college students can be impacted by aspects of public stigma, self‐stigma, and mental health literacy. The unique influences of these factors, however, have yet to be explored with African American male college students (AAMCS). Using a sample of 116 AAMCS, the researchers examined changes of variances in AAMCS’ help‐seeking intentions explained by public stigma, self‐stigma, mental health literacy, and self‐construal. Our hierarchical regression analyses revealed public stigma and self‐stigma to account for 13.7% (ΔR2 = 0.137) of variance in predicting help‐seeking intentions of AAMCS. Mental health literacy and self‐construal were not found to be statistically significant in their respective models. The overall hierarchical model accounted for 25.9% of variance in help‐seeking intentions of AAMCS. Implications for counseling practice and future research in help‐seeking are discussed.
Credit default swap and Japanese Government Bond markets under negative interest rate policy
Authors: Ito Takayasu 
Published: March 2022

AbstractStructural changes have taken place in the markets of credit default swap (CDS) and Japanese Government Bond (JGB) after the Bank of Japan (BOJ) introduced yield curve control (YCC) under a negative interest rate policy. CDS and JGB markets were segmented before the introduction of YCC. Whether CDS markets function as insurance against the JGB market or cannot be confirmed because no causalities were found between CDS and JGB markets. However, they are integrated under a negative interest rate policy with YCC. The CDS market does not function as insurance because unilateral causalities from CDS to JGB markets were found. The purpose of YCC's introduction was an upward adjustment of the yield curve because the flattening of the yield curve damaged bank profits. A positive yield in a 10‐year JGB has become an incentive to investors. The markets of CDS and JGB have started to be integrated because JGB has regained a market and price discovery function with the introduction of YCC.
Partial geometric designs having circulant concurrence matrices
Authors: Song Sung‐Yell , Tranel Theodore 
Published: March 2022

AbstractWe classify small partial geometric designs (PGDs) by spectral characteristics of their concurrence matrices. It is well known that the concurrence matrix of a PGD can have at most three distinct eigenvalues, all of which are nonnegative integers. The matrix contains useful information on the incidence structure of the design. An ordinary 2‐ design has a single concurrence , and its concurrence matrix is circulant, a partial geometry has two concurrences 1 and 0, and a transversal design has two concurrences and 0, and its concurrence matrix is circulant. In this paper, we survey the known PGDs by highlighting their concurrences and constructions. Then we investigate which symmetric circulant matrices are realized as the concurrence matrices of PGDs. In particular, we try to give a list of all PGDs of order up to 12 each of which has a circulant concurrence matrix. We then describe these designs along with their combinatorial properties and constructions. This work is part of the second author's Ph.D. dissertation [46].
Paradoxical mortality of high estimated glomerular filtration rate reversed by 24‐h urine creatinine excretion rate adjustment: sarcopenia matters
Authors: Kao Pei‐Yu , Yeh Hung‐Chieh , Hsia Ying‐Fang , Hsiao Ya‐Luan , Wang Jie‐Sian , Chang David Ray , Chang Shih‐Ni , Chiang Hsiu‐Yin , Kuo Chin‐Chi 
Published: March 2022

AbstractBackgroundMuscle wasting may explain the paradoxical mortality of patients with high estimated glomerular filtration rates (eGFRs) derived from equation methods. However, empirical evidence and solutions remain insufficient.MethodsIn this retrospective cohort study, we compared the performance of equation methods for predicting all‐cause mortality; we used 24‐h creatinine clearance (24‐h CrCl), equation‐based eGFRs, and a new eGFR estimating equation weighting for population 24‐h urine creatinine excretion rate (U‐CER). From 2003 to 2018, we identified 4986 patients whose data constituted the first 24‐h CrCl measurement data in the Clinical Research Data Repository of China Medical University Hospital and were followed up for at least 5 years after careful exclusion. Three GFR estimation equations [the Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI), Modification of Diet in Renal Disease (MDRD) Study, and Taiwanese MDRD], 24‐h CrCl, and 24‐h U‐CER–adjusted eGFR were used.ResultsA high correlation was observed among the eGFR levels derived from the equation methods (0.995–1.000); however, the correlation decreased to 0.895–0.914 when equation methods were compared with the 24‐h CrCl or 24‐h U‐CER–adjusted equation‐based eGFR. In the Bland–Altman plots, the average discrepancy between the equation methods and the 24‐h CrCl method was close to zero (maximal bias range: 5.12 for the Taiwanese MDRD equation vs. 24‐h CrCl), but the range in limit of agreement was wide, from ±43.7 mL/min/1.73 m2 for the CKD‐EPI equation to ±54.3 mL/min/1.73 m2 for the Taiwanese MDRD equation. A J‐shaped dose–response relationship was observed between all equation‐based eGFRs and all‐cause mortality. Only 24‐h CrCl exhibited a non‐linear negative dose–response relationship with all‐cause mortality. After adjustment for 24‐h U‐CER in the statistical model, the paradoxical increase in mortality risk for an eGFR of >90 mL/min/1.73 m2 returned to null. When 24‐h U‐CER was used directly to correct eGFR, the monotonic non‐linear negative relationship with all‐cause mortality was almost identical to that of 24‐h CrCl.ConclusionsThe 24‐h U‐CER–adjusted eGFR and 24‐h CrCl are viable options for informing mortality risk. The 24‐h U‐CER adjustment method can be practically implemented to eGFR‐based care and effectively mitigate the inherent confounding biases from individual's muscle mass amount due to both sex and racial differences.
Impact of biliary stenting in endoscopic ultrasound‐guided tissue acquisition among patients with pancreatic cancer
Authors: Constantinescu Alexandru , Plotogea Oana‐Mihaela , Stan‐Ilie Mădălina , Ciurea Tudorel , Gheonea Dan Ionut , Ungureanu Bogdan Silviu , Bălan Gheorghe , Rinja Ecaterina , Panic Nikola , Şandru Vasile , Constantinescu Gabriel 
Published: March 2022

AbstractIntroductionPancreatic malignancies represent highly fatal diseases with poor prognosis and constantly increasing incidence despite modern diagnostic and therapeutic options. Both endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) are regarded as mainstays in pancreatic cancer management. The present study aims to evaluate whether accuracy EUS with fine‐needle aspiration or biopsy (FNA or FNB) in pancreatic cancer diagnosis is influenced by prior biliary stenting or by technical or anatomical features (stent type, number of needle passes, common bile duct or Wirsung's diameter, topographical characteristics and diameter of the pancreatic tumor).Materials and methodsThis retrospective study includes 243 patients with pancreatic cancer who underwent ERCP and EUS with fine‐needle aspiration or biopsy (FNA or FNB).Results and discussionOut of the total number of patients, 68 were stented prior to EUS. We found that the EUS‐FNA diagnostic yield is not influenced either by the presence of biliary stent, nor by the type of stent (plastic or metallic). Moreover, the mean needle passes required were similar for both stented patients and not stented ones.ConclusionsUltimately, given our results, we can state that EUS‐FNA/FNB can be safely and accurately performed in the presence of biliary stents.
Students’ and tutors’ perceptions of a deliberate simulated practice using patient‐specific virtual and three‐dimensional printed teeth models: A pilot study
Authors: Tricio Jorge A. , Kleiman Sofía E. , Eiriksson Vilborg I. , Vicuña Daniela P. , Cacciuttolo Franco R. , Jorquera Gilbert A. , Córdova Christian G. , Gualda José I. , Gutiérrez Mario F. , Villalón Pablo A. , Orsini César A. 
Published: March 2022

AbstractObjectiveThis pilot study aimed to investigate the perceptions of dental students and their tutors of a deliberate simulated practice using patient‐specific virtual and three‐dimensional (3D) printed teeth models. This is before they perform their first indirect posterior tooth restoration on their patients.MethodsSeventy‐eight fourth‐year dental students from the 2021 Comprehensive Clinic I course at the University of the Andes, Chile, were invited to participate in a deliberate practice protocol. This consisted of digitally scanning their patients’ teeth, printing the files three‐dimensionally, and loading them into a virtual reality (VR) dental simulator to create patient‐specific models. Subsequently, they practiced the same indirect posterior restorations on these models before performing them on their actual patients. Perceptions about students’ preparedness to perform tooth preparations before and after the protocol were collected from students and their tutors through surveys.ResultsSixty‐three students (43 female) and six clinical tutors (all male) participated in the study. Before practicing with their patient‐specific models, most students believed they had the knowledge, practical skills, and self‐confidence to perform indirect restorations on their patients. However, after the protocol, most students thought their self‐confidence increased and felt better prepared to treat their patients. Most students preferred the 3D‐printed models over the VR models to practice but mentioned that it did not feel like drilling dental enamel. Tutors believed that participating students had higher self‐confidence when treating their patients and were more autonomous.ConclusionsThis study demonstrated that students and clinical tutors had positive perceptions of practicing with patient‐specific virtual and 3D‐printed teeth models before students performed their first indirect restorations on their patients.
Effect of shift to virtual teaching on active learning: A snapshot
Authors: Dalal Ayushi R. , Joy‐Thomas Anita R. , Quock Ryan L. 
Published: March 2022

AbstractPurposeActive learning engages students via interaction for deeper understanding and retention. A global pandemic resulted in an abrupt mid‐semester transition from in‐person to virtual learning. This study examined student reporting on active learning before and after this transition.MethodsFirst‐year DDS candidates took an anonymous survey, reflecting on three Spring (January–April) 2020 courses (lecture‐style, small‐group case‐based, and pre‐clinical). Survey questions included: (1) basic demographics, (2) reporting frequency (1–Never, 2–Rarely, 3–Sometimes, 4–Often, 5–Always) of active learning elements from a pre‐set list before/after the shift to online learning, and (3) Likert‐style questions regarding effects on active learning and learning environment preference.ResultsThe traditional lecture course manifested two active learning activities in the category Sometimes prior to the transition to virtual; one of those activities (question and answer) experienced the most significant difference (p < 0.0001) in frequency change. The small group, case‐based course incorporated nine activities in‐person in the category Sometimes; although small significant differences (p ≤ 0.05) in frequency were noted for five of those activities between virtual and in‐person, these differences may have not have made a difference in practice. The pre‐clinical course incorporated four activities in the category Sometimes pre‐transition, with no significant differences detected in frequency. Students slightly leaned toward preferring in‐person for the small‐group and pre‐clinical courses, but had no preference for the traditional lecture course.ConclusionsCourse structure may correlate more with student experience of the frequency of active learning activities and preference for in‐person versus virtual environment than the environment itself.
Social recognition and short‐term memory in two taxa of striped mouse with differing social systems
Authors: Neves Candice N. , Pillay Neville 
Published: March 2022

AbstractThe ability to distinguish between familiar and strange conspecifics is important in group‐living animals and influences the types of interactions between conspecifics. Social systems differ in sister taxa of the striped mouse genusRhabdomysoriginating from different environments. Xeric‐adaptedR. pumiliodisplays facultative group‐living whereas the mesic‐adaptedR. d. chakaeis solitary. We assessed social recognition and attraction to strangers in females of two populations each ofR. pumilioandR. d. chakaeby means of a social discrimination task. We used a three‐chamber apparatus developed in an established protocol and measured the latency of test females to approach and the duration of their investigation of stimulus females. Differences in social recognition of and preference for unfamiliar conspecifics in group‐living and solitary‐living taxa occurred at the taxon‐level, even though constituent populations occurring kilometers apart showed similar responses. Females differed in the latency (testing phase) and duration of investigation (familiarization and testing phases) inter‐specifically but not intra‐specifically. FemaleR. pumilioapproached stimulus females faster than femaleR. d. chakae. FemaleR. pumilioalso investigated stimulus females for longer, regardless of stimulus type compared toR. d. chakae, but both taxa spent more time investigating familiar females than novel females and approached the familiar females faster than novel females. Social recognition, short‐term memory, and social preference do not appear to differ between closely related taxa and differences in behavior between the two taxa might be related to inherent personality and social proclivity.
Carvedilol versus propranolol in the prevention of variceal rebleeding in hepatosplenic schistosomiasis: Efficacy and safety
Authors: Razafindrazoto Chantelli Iamblaudiot , Razafindrabekoto Lova Dany Ella , Hasina Laingonirina Domoina Harivonjy , Raveloson Raveloson , Rasolonjatovo Anjaramalala Sitraka , Rakotozafindrabe Andry Lalaina Rinà , Rabenjanahary Tovo Harimanana , Razafimahefa Soloniaina Hélio , Ramanampamonjy Rado Manitrala 
Published: March 2022

AbstractBackground and AimBeta blockers combined with endoscopic variceal band ligation (EVL) is the most effective means for the prevention of variceal rebleeding. No data are available on the efficacy of carvedilol in the secondary prophylaxis of variceal bleeding in hepatosplenic schistosomiasis. The aim of this study was to evaluate the efficacy and safety of carvedilol compared to propranolol as secondary prophylaxis of variceal bleeding in hepatosplenic schistosomiasis.MethodsThis was a prospective, randomized study over a period of 14 months from February 2019 to March 2020. All patients with portal hypertension due to schistosomiasis with at least one episode of variceal bleeding were included and randomized to the propranolol and carvedilol groups. EVL protocol was continued in both groups.ResultsSixty‐one patients were eligible and randomized to propranolol (n = 30) and carvedilol (n = 31) groups. There was no significant difference in hemorrhagic recurrence between the carvedilol (n = 1) and propranolol (n = 3) groups (3.33 vs 10%; P = 0.30). At 4 months, there was a significant reduction in mean arterial pressure (−4.13 mm Hg; 95% CI: −6.27 to −1.99; P < 0.05) and heart rate (−12.13 bpm; 95% CI: −13.92 to −10.35; P < 0.05) in the carvedilol group. There was no significant difference between the groups on the mean difference in arterial pressure. One patient in the carvedilol group had breathing difficulty. There were no adverse events in the propranolol group.ConclusionThere was no significant difference in the efficacy between carvedilol and propranolol. Carvedilol may be an alternative to propranolol for secondary prophylaxis of variceal rebleeding in hepatosplenic schistosomiasis.