bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphorescent Complexes of {Mo6I8}4+ and {W6I8}4+ with Perfluorinated Aryl Thiolates featuring Unusual Molecular Structures
Authors: Mironova Alina D. , Mikhaylov Maksim A. , Maksimov Alexander M. , Brylev Konstantin A. , Gushchin Artem L. , Stass Dmitry V. , Novikov Alexander S. , Eltsov Ilia V. , Abramov Pavel A. , Sokolov Maxim N. 
Published: December 2021

AbstractA series of six novel cluster complexes [M6I8(SArf)6]2− (M=Mo or W; SArf=p‐SC6F4‐C6F5, p‐SC6F4Cl, or p‐SC6F4CF3) was prepared by exchange reactions between [Mo6I14]2− or [W6I14]2− and silver salts of the corresponding thiols and characterized by X‐ray single‐crystal diffraction and elemental analysis, NMR, ESI‐MS, and CV techniques. In the crystal structures all the thiolate ligands adopt an idiosyncratic orientation along one of the idealized three‐fold axes passing through two opposite μ3‐I ligands and the centers of two opposite faces of the M6 octahedra. This leads to shortened intramolecular C⋅⋅⋅I distances inside the cluster below 3.5 Å. The clusters exhibit red photoluminescence with relatively high quantum yield, up to 0.42 in the case of (Bu4N)2[W6I8(SC6F4CF3)6]. Moreover, all the compounds exhibit X‐ray luminescence; the close values of the maxima in the photo‐ and X‐ray induced emission spectra indicate that the luminescence is cluster‐centered.
A [1H,15N] Heteronuclear Single Quantum Coherence NMR Study of the Solution Reactivity of the Ruthenium‐Based Mitochondrial Calcium Uniporter Inhibitor Ru265
Authors: Woods Joshua J. , Spivey Jesse A. , Wilson Justin J. 
Published: December 2021

AbstractThe synthesis and characterization of the 15N‐labeled analogue of the mitochondrial calcium uptake inhibitor [Cl(NH3)4Ru(μ‐N)Ru(NH3)4Cl]3+ (Ru265) bearing [15N]NH3 ligands is reported. Using [1H,15N] HSQC NMR spectroscopy, the rate constants for the axial chlorido ligand aquation of [15N]Ru265 in pH 7.4 buffer at 25 °C were found to be k1=(3.43±0.03)×10−4 s−1 and k2=(4.03±0.09)×10−3 s−1. The reactivity of [15N]Ru265 towards biologically relevant small molecules was also assessed via this method, revealing that this complex can form coordination bonds to anionic oxygen and sulfur donors. Time‐based studies on these ligand‐binding reactions reveal this process to be slow relative to the time required for the complex to inhibit mitochondrial calcium uptake, suggesting that hydrogen‐bonding interactions, rather than the formation of coordination bonds, may play a more significant role in mediating the inhibitory properties of this complex.
Multispin Systems with a Rigid Ferrocene‐1,1′‐diyl‐Substituted 1,3‐Diazetidine‐2,4‐diimine Coupler: A General Approach
Authors: Gurskaya Larisa Yu. , Polienko Yuliya F. , Rybalova Tatyana V. , Gritsan Nina P. , Dmitriev Alexey A. , Kazantsev Maxim S. , Zaytseva Elena V. , Parkhomenko Dmitry A. , Beregovaya Irina V. , Zakabluk Galina A. , Tretyakov Evgeny V. 
Published: December 2021

AbstractThis paper describes the stepwise aza‐Wittig reaction of 1,1′‐bis(triphenylphosphoranylidenamino)‐ferrocene with a paramagnetic isocyanate, namely, 3‐isocyanato‐2,2,5,5‐tetramethyl‐2,5‐dihydro‐1H‐pyrrole‐1‐oxyl, and then with substituted arylisocyanates. The intermediate product (a paramagnetic betaine), which is the product of an intramolecular nucleophilic attack of the nitrogen atom of the iminophosphorane moiety on the carbon atom of the carbodiimide functional group, was isolated and structurally characterized. Subsequent interaction of the betaine with arylisocyanates under mild conditions gave spin‐labeled ferrocenophanes with the 1,3‐diazetidine‐2,4‐diimine coupler. It was found that the mutual arrangement of the substituents in the latter depends on the nature of the substituents in the arylisocyanate. Iodophenyl derivatives of 1,3‐diazetidine‐2,4‐diimines were cross‐coupled with the gold(I) nitronyl nitroxide‐2‐ide complex, thus yielding diradicals: metallocenophanes functionalized with various types of nitroxide substituents. Molecular and crystal structures of all mono‐ and diradicals were solved by X‐ray diffraction analysis.
High Sensitive Voltammetric Gentamicin Sensor using Poly (3‐thiophenecarboxylic acid‐co‐3‐methylthiophene) Modified Glassy Carbon Electrode
Authors: Burç Muammer , Titretir Duran Serap , Güngör Öznur , Köytepe Süleyman 
Published: December 2021

AbstractFor the determination of gentamicin in biomedical applications, sensitive, fast and low cost voltammetric sensor has been developed. Prepared sensor was successfully used for determination of gentamicine in synthetic urine samples with different voltammetric measurement methods. Firstly, glassy carbon electrode was modified using cyclic voltammetry technique by electropolymerization of 3‐thiophenecarboxylic acid and 3‐methylthiophene. Then, optimization of the electrochemical parameters was carried out for modified electrode. With this modified electrode, gentamicin determination was performed in the linear range of 0.05–4.00 mM. The correlation coefficient, limit of detection and limit of quantitation were calculated as 0.9999, 0.039 mM and 0.129 mM, respectively.
CN‐3 increases TMZ sensitivity and induces ROS‐dependent apoptosis and autophagy in TMZ‐resistance glioblastoma
Authors: Xue Yu‐Ye , Lu Yun‐Yang , Sun Guang‐Qiang , Fang Fei , Ji Yu‐Qiang , Tang Hai‐Feng , Qiu Peng‐Cheng , Cheng Guang 
Published: December 2021

AbstractMany glioma patients develop resistance to temozolomide (TMZ) treatment, resulting in reduced efficacy and survival rates. TMZ‐resistant cell lines SHG44R and U87R, which highly express O6‐methylguanine DNA methyltransferase (MGMT) and P‐gp, were established. CN‐3, a new asterosaponin, showed cytotoxic effects on TMZ‐resistant cells in a dose‐ and time‐dependent manner via reactive oxygen species (ROS)‐mediated apoptosis and autophagy. Transmission electron microscopy and monodansylcadaverine (MDC) staining showed turgidity of the mitochondria and autophagosomes in CN‐3‐treated SHG44R and U87R cells. The autophagy inhibitor 3‐methyladenine was used to confirm the important role of autophagy in CN‐3 cytotoxicity in TMZ‐resistant cells. The ROS scavenger N‐acetyl‐
l‐cysteine (NAC) attenuated the levels of ROS induced by CN‐3 and, therefore, rescued the CN‐3 cytotoxic effect on the viability of SHG44R and U87R cells by Cell Counting Kit‐8 assays and JuLI‐Stage videos. MDC staining also confirmed that NAC rescued an autophagosome increase in CN‐3‐treated SHG44R and U87R cells. Western blotting revealed that CN‐3 increased Bax, cleaved‐caspase 3, cytochrome C, PARP‐1, LC3‐Ⅱ, and Beclin1, and decreased P‐AKT, Bcl‐2, and p62. Further rescue experiments revealed that CN‐3 induced apoptosis and autophagy through ROS‐mediated cytochrome C, cleaved‐caspase 3, Bcl‐2, P‐AKT, PARP‐1, and LC3‐Ⅱ. In addition, CN‐3 promoted SHG44R and U87R cells sensitive to TMZ by reducing the expression of P‐gp, MGMT, and nuclear factor kappa B p65, and it had a synergistic cytotoxic effect with TMZ. Moreover, CN‐3 disrupted the natural cycle arrest and inhibited the migration of SHG44R and U87R cells by promoting cyclin E1 and D1, and by decreasing P21, P27, N‐cadherin, β‐catenin, transforming growth factor beta 1, and Smad2.
Infectious risks in patients treated with extracorporeal photopheresis for graft‐versus‐host disease: A retrospective cohort study
Authors: Thevenet Ugo , Daguenet Elisabeth , Beszera Silvia‐Maria , Cornillon Jérôme , Tavernier Emmanuelle , Schein Flora , Honeyman Fressia , Guyotat Denis 
Published: December 2021

AbstractBackgroundInfections are common with significant mortality and morbidity in patients with graft‐versus‐host disease (GvHD). Extracorporeal photopheresis (ECP) is an advantageous treatment option for patients with GvHD because it is not immunosuppressive. The objective of this study was to assess the rate of infections and to determine risk factors in patients with GvHD.Materials and MethodsIn a single‐center cohort, we retrospectively collected data on infectious episodes by evaluating the clinical records of patients with GvHD treated by ECP since 2011.ResultsA total of 47 patients were included in this study. At ECP initiation, there were 10 patients with acute GvHD and 37 with chronic GvHD. At the final follow‐up, 200 infectious episodes were diagnosed in 91.5% of patients with an average follow‐up of 25.9 months (ie, 1.97 infections per patient per year). Most episodes had positive outcomes as there was no death related to infections, and only six infections required long‐term treatment. Higher dose of corticosteroids at the initiation of ECP was significantly associated with a shorter onset of the first infection (hazard ratio [HR] = 2.05; 95% confidence interval [CI] [1.17, 3.57]; P = .013). Unrelated donor transplants were significantly associated with a lower rate of infection (HR = 0.61; 95% CI [0.39, 0.95]; P = .028).ConclusionThe results of our study suggest that ECP is associated with a low infection rate and an optimal clinical efficacy. Thus, ECP is still a suitable treatment for GvHD. Yet, a future study with a larger cohort will be necessary to deepen the identification of risk factors for infection.
Factors associated with county‐level mental health during the COVID‐19 pandemic
Authors: Lupton‐Smith Carly , Badillo‐Goicochea Elena , Chang Ting‐Hsuan , Maniates Hannah , Riehm Kira E. , Schmid Ian , Stuart Elizabeth A. 
Published: December 2021

AbstractThe objective of this study is to determine county‐level factors associated with anxiety, depression, and isolation during the coronavirus disease 2019 (COVID‐19) pandemic. This study used daily data from 23,592,355 respondents of a nationwide Facebook‐based survey from April 2020 to July 2021, aggregated to the week‐county level to yield 212,581 observations. Mental distress prevalences were modeled using weighted linear mixed‐effects models with a county random effect. These models revealed that weekly percentages of mental distress were higher in counties with higher unemployment rates, populations, and education levels; higher percentages of females, young adults, individuals with a medical condition, and individuals very worried about their finances and COVID‐19; and lower percentages of individuals who were working outside the home, living with children, without health insurance, and Black. Anxiety peaked in April 2020, depression in October 2020, and isolation in December 2020. Therefore, United States counties experienced the mental health effects of the pandemic differently dependent upon their characteristics, and mental distress prevalence varied across time.
Efficacy and Safety of Adjunctive Serotonin‐Dopamine Activity Modulators in Major Depression: A Meta‐Analysis of Randomized Controlled Trials
Authors: Mishra Archana , Sarangi Sudhir Chandra , Maiti Rituparna , Sood Mamta , Reeta KH 
Published: December 2021

AbstractSerotonin‐dopamine activity modulators (SDAMs) have been approved as an adjunctive treatment to antidepressants in patients with inadequate response. These drugs have been proposed to have a beneficial effect on cognition, sleep‐related problems, and other affective symptoms in patients with depression. Previous studies have shown inconsistent evidence and have not reported a pooled effect of the 2 drugs of this class: aripiprazole and brexpiprazole. This meta‐analysis evaluated the effect of augmentation with SDAM drugs in patients with major depression. The meta‐analysis protocol was made as per Preferred Reporting Items for Systematic Reviews and Meta‐Analysis Protocol guidelines and registered in the International Prospective Register of Ongoing Systematic Reviews. The PubMed/MEDLINE, Cochrane Clinical Trial registry, and EudraCT databases were searched with prespecified search terms. A random‐effects meta‐analysis was performed using the meta package in R software. Fifteen studies were included in this meta‐analysis. The random‐effects model analysis observed a pooled effect of 1.55 (95%CI, 1.32‐1.84; prediction interval, 0.95‐2.55, z = 5.19 [P < .0001]) for remission between the SDAM and placebo groups. A pooled effect of 1.58 (95%CI, 1.37‐1.83; prediction interval, 1.00–2.51, z = 6.34 [P < .0001]) for adverse events and 0.72 (95%CI, 0.48‐1.08; prediction interval, 0.46‐1.12; z = −1.58 [P = .113]) for serious adverse events was observed. No significant publication bias was noticed. The quality of the evidence was rated as high. Adjunct SDAM increased remission in patients and had no significant effect on serious adverse events compared to placebo. Therefore, we conclude that SDAM drugs can be an effective and safe antidepressant augmentation strategy in patients with major depressive disorder.
Association study of miR‐149, miR‐196a2, and miR‐499a polymorphisms with coronary artery aneurysm of Kawasaki disease in southern Chinese population
Authors: Fu Lanyan , Xu Yufen , Yu Hongyan , Pi Lei , Li Jinqing , Zhou Huazhong , Zhang Li , Zhang Tingfang , Che Di , Gu Xiaoqiong 
Published: December 2021

AbstractBackgroundAccumulating evidence suggests that several microRNA (miRNA) polymorphisms are closely associated with disease susceptibility or progression, such as in Kawasaki disease (KD). Our previous studies revealed the association of miR‐149 rs2292832 T>C and miR‐196a2 rs11614913 C>T polymorphisms with KD susceptibility. The present study further focused on the relationship between three miRNA polymorphisms (miR‐149 rs2292832 T>C, miR‐196a2 rs11614913 C>T and miR‐499a rs3746444 A>G) and the risk of coronary artery aneurysm (CAA) in southern Chinese KD patients.MethodsWe evaluated 318 KD patients with CAAs and 784 patients without CAAs. TaqMan assays were used to estimate genotyping and analyze the relationship between miRNA polymorphisms (miR‐149 rs2292832 T>C, miR‐196a2 rs11614913 C>T and miR‐499a rs3746444 A>G) and risk associations of CAA by odds ratios (ORs) and 95% confidence intervals (CIs).ResultsWe found that the miR‐149 rs2292832 TC/CC genotype increased the CAA risk (adjusted OR = 1.53, 95% CI = 1.15–2.03, p = 0.003 for TC, adjusted OR = 1.63, 95% CI = 1.08–2.47, p = 0.021 for CC), whereas the miR‐499a rs3746444 AG genotype decreased the CAA risk in KD patients (adjusted OR = 0.33, 95% CI = 0.25–0.45 p ≤ 0.001). Moreover, patients carrying two or three of these single nucleotide polymorphism (SNP) genotypes (rs2292832 TC/CC and rs11614913 TT and rs3746444 AA) had a higher risk for CAA than those who harbored only zero or one of these SNP genotypes.ConclusionsOur results demonstrated that the miR‐149 rs2292832 T>C polymorphism increased the risk of CAA in KD patients and that the miR‐499a rs3746444 A>G polymorphism decreased the risk of CAA in KD patients. Further studies with larger sample sizes and different centers are needed to confirm the findings of the present study.
Poly(N‐vinyl‐2‐pyrrolidone)‐supported ferric chloride: An effective reusable heterogeneous catalyst for one‐pot synthesis of 3,4‐dihydropyrimidin‐2(1H)‐ones/thiones via three‐component Biginelli reaction
Authors: Rahmatpour Ali , Donyapeyma Ghazaleh 
Published: December 2021

AbstractAn environmentally benign three‐component Biginelli protocol for the one‐pot synthesis of substituted 3,4‐dihydropyrimidin‐2(1H)‐ones/thiones using an accessible, nontoxic, easy to handle, and recoverable macromolecular Lewis acidic catalyst is developed. N,N′‐methylene bis‐acrylamide‐cross‐linked poly(N‐vinyl‐2‐pyrrolidone) (MBA‐PVNP) as beads was used as a support for ferric chloride, resulting in a heterogeneous and reusable catalyst. The reusability test of the heterogenized version of ferric chloride, PNVP/FeCl3 ascertained that the obtained catalyst can be easily separated from the reaction mixture by filtration and reused several times with no great decline of activity.
Hyperglycemia and blood glucose deterioration are risk factors for severe COVID‐19 with diabetes: A two‐center cohort study
Authors: Xiao Fen , Zhou Ying‐Chu , Zhang Mei‐Biao , Chen Dong , Peng Shao‐Lin , Tang Hao‐Neng , Li Long , Tang Chen‐Yi , Liu Ji‐Yang , Li Bo , Zhou Hou‐De 
Published: December 2021

AbstractWe aimed to assess whether blood glucose control can be used as predictors for the severity of 2019 coronavirus disease (COVID‐19) and to improve the management of diabetic patients with COVID‐19. A two‐center cohort with a total of 241 confirmed cases of COVID‐19 with definite outcomes was studied. After the diagnosis of COVID‐19, the clinical data and laboratory results were collected, the fasting blood glucose levels were followed up at initial, middle stage of admission and discharge, the severity of the COVID‐19 was assessed at any time from admission to discharge. Hyperglycemia patients with COVID‐19 were divided into three groups: good blood glucose control, fair blood glucose control, and blood glucose deterioration. The relationship of blood glucose levels, blood glucose control status, and severe COVID‐19 were analyzed by univariate and multivariable regression analysis. In our cohort, 21.16% were severe cases and 78.84% were nonsevere cases. Admission hyperglycemia (adjusted odds ratio [aOR], 1.938; 95% confidence interval [95% CI], 1.387–2.707), mid‐term hyperglycemia (aOR, 1.758; 95% CI, 1.325–2.332), and blood glucose deterioration (aOR, 22.783; 95% CI, 2.661–195.071) were identified as the risk factors of severe COVID‐19. Receiver operating characteristic (ROC) curve analysis, reaching an area under ROC curve of 0.806, and a sensitivity and specificity of 80.40% and 68.40%, respectively, revealed that hyperglycemia on admission and blood glucose deterioration of diabetic patients are potential predictive factors for severe COVID‐19. Our results indicated that admission hyperglycemia and blood glucose deterioration were positively correlated with the risk factor for severe COVID‐19, and deterioration of blood glucose may be more likely to the occurrence of severe illness in COVID‐19.
Relative instantaneous reproduction number of Omicron SARS‐CoV‐2 variant with respect to the Delta variant in Denmark
Authors: Ito Kimihito , Piantham Chayada , Nishiura Hiroshi 
Published: December 2021

AbstractThe Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has become widespread across the world in a flashing manner. As of December 7, 2021, a total of 758 Omicron cases were confirmed in Denmark. Using the nucleotide sequences of the Delta and Omicron variants registered from Denmark in the GISAID database, we found that the effective (instantaneous) reproduction number of Omicron is 3.19 (95% confidence interval [CI]: 2.82–3.61) times greater than that of Delta under the same epidemiological conditions. The proportion of Omicron infections among all SARS‐CoV‐2 infections in Denmark was expected to exceed 95% on December 28, 2021, with a 95% CI from December 25 to December 31, 2021. Given that the Delta variant or variants less transmissible than Delta are dominant in most countries, the rapid increase in Omicron in the virus population may be observed as soon as the Omicron is introduced. Preparing proactive control measures is vital, assuming the substantial advantage of the transmission by Omicron.
Prevalence and impact of malnutrition on length of stay, readmission, and discharge destination
Authors: Lengfelder Lucy , Mahlke Sarah , Moore Lynn , Zhang Xu , Williams George , Lee Jenny 
Published: December 2021

AbstractBackgroundStudies indicate one in three hospitalized patients are malnourished on admission; however, the documented malnutrition rate in acute care hospitals is often lower. This study measured prevalence of malnutrition on admission and correlated the relationship among malnutrition status, length of stay (LOS), discharge disposition, and readmission rate.MethodsA prospective observational cohort study was performed across nine tertiary care hospitals in Houston, Texas. Registered dietitians screened patients aged ≥18 years within 24 h of admission for two consecutive days per hospital. Malnourished patients were diagnosed using a modified version of the 2012 Consensus Statement from the Academy of Nutrition and Dietetics (AND)/American Society for Parenteral and Enteral Nutrition (ASPEN). Data collected included demographics, LOS, discharge disposition, and 30‐day readmission status.ResultsIn 416 patients, 31.7% were malnourished on admission. Malnourished patients were significantly older (67.8 vs 57.6 years;P< 0.001) and had a lower body mass index (26.2 vs 32.4;P< 0.001) than nonmalnourished patients. Malnourished patients had higher odds of having a LOS of ≥3 days (2.38 [95% CI, 1.45 to 3.88];P< 0.001) and higher odds of readmitting within 30 days (2.28 [95% CI, 1.26 to 4.12];P< 0.006) when compared with nonmalnourished patients. There were no significantly different clinical outcomes between moderately and severely malnourished groups.ConclusionThe study successfully utilized the modified AND‐ASPEN criteria to show that approximately one in three patients presented with malnutrition on admission. Malnourished patients were more likely to have a longer LOS and more likely to be readmitted within 30 days.
Mindfulness enhances the values that promote sustainable consumption
Authors: Kaur Tavleen , Luchs Michael G. 
Published: December 2021

AbstractPrior research has demonstrated the critical role of values in promoting sustainable consumption behaviors. However, research is needed to identify novel ways to influence these values so that consumers will act on them. The present research demonstrates a practical and underappreciated way to enhance the values that promote sustainable consumption behaviors. Specifically, we demonstrate that mindfulness has a positive relationship with biospheric and altruistic values (but not egoistic values), and that these values mediate the relationship between mindfulness and two distinct forms of sustainable consumption: socially conscious consumption and frugal (i.e., reduced) consumption. We employ a series of three studies with sample populations drawn from different countries, and we use multiple measures for each of our focal constructs to demonstrate the robustness of our findings. Our findings suggest that marketers and policy makers can integrate mindfulness into their promotion and education initiatives as a means to help consumers clarify their values and, thereby, increase levels of sustainable consumption.
“YOU POST, I TRAVEL.” Bloggers' credibility, digital engagement, and travelers' behavioral intention: The mediating role of hedonic and utilitarian motivations
Authors: Mainolfi Giada , Lo Presti Letizia , Marino Vittoria , Filieri Raffaele 
Published: December 2021

AbstractBloggers are becoming increasingly relevant in consumers' decisions, particularly travel decisions. This study has investigated the influence of bloggers across cultures and from different theoretical perspectives. Drawing upon source credibility, uses and gratification theory, and content engagement constructs, we propose an integrated model of bloggers' influence investigating the role of credibility, motivations and engagement in the information adoption process of travel blog readers. Results from a survey of Italian and American consumers show that blogger credibility positively influences hedonic and utilitarian motivations to read a blogger post, but it does not affect digital engagement. Further, hedonic and utilitarian motivations significantly affect blog engagement (utilitarian motivation's influence not significant in the Italian sample), which, in turn, positively influences both continued use and electronic word of mouth (eWOM). Moreover, continued use influences information adoption in both samples. The study contributes to knowledge about the interplay between source credibility, utilitarian and hedonic motivations, and engagement on consumers' intentions (i.e., information adoption, eWOM, continued use) in the context of blogging.