bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinan pengungkapan aset biologis pada perusahaan agrikultur yang terdaftar di BEI
Authors: Fitriasuri Fitriasuri , Putri Melinda Astria 
Published: October 2022

This study aims to empirically prove the effect of biological assets intensity, firm size, Ownership Concentration, type of KAP, firm growth, and profitability on the disclosure of biological assets.. This type of research is quantitative research. The population in this study is all financial data of agricultural companies listed on the IDX in 2019-2021 as many as 26 companies. The sampling technique in this study used a purposive sampling technique for as many as 14 companies. The data analysis technique used descriptive statistical analysis, classical assumption test, multiple linear regression analysis, Coefficient of Determination, Simultaneous Test (F-Test), and Partial Test (T-Test) processed with SPSS 26. The results of this test indicate that the variable biological asset intensity and profitability have a significant positive effect on the disclosure of biological assets, and the type of KAP variable has a significant negative effect on the disclosure of biological assets. While the variables of firm size, ownership concentration, and firm growth do not affect the disclosure of biological assets.
Determinan Deteksi Financial Statement Fraud
Authors: Patmawati Patmawati , Rahmawati Meita , Hidayat Muhammad , Damar Sagara Sitepu Christian 
Published: October 2022

This study aims to empirically test the determinants of financial statement fraud detection with the Beneish M-Score, F-Score and Altman Z-Score models. The difference between this study and the previous study is that this study adds the F-Score model variable which is a financial statement fraud detection model developed using the scaled logistic probability technique. The population of this study is all banks listed on the Indonesia Stock Exchange. The samples in this study were perbankan that met the purposive sampling criteria. Based on the results of statistical tests obtained from the results of the study, the Beneish M-Score model has a significant effect on the financial statementt fraud variables, namely the Gross Margin Index (GMI) and the Asset Quality Index (AQI) variable while the Days Sales in Receivables Index (DSRI) variable, Leverage Index (LVGI), Total Accruals to Total Assets (TATA), and the Sales General and Administrative Expenses Index (SGAI) have no effect on the financial statement fraud variable. The F-Score variable states that only the Change in cash sales (Ch CS) variable has a significant effect on financial statement fraud while the change in receivable variable (Ch Rev), change in inventories (Ch Inv) and the change in earnings variable (Ch Ear) have a significant effect on the financial statement fraud variable. Meanwhile, the Altman Z-Score variable states that the Z-Score1 variable and the Z-Score3 variable have a significant effect on the financial statement fraud variable while the Z-Score2 variable and the Z-Score5 variable have no significant effect.
EFEKTIFITAS TERAPI KOMPLEMENTER : TUINA AKUPOIN DAN FACIAL LOVING TOUCH DALAM MENINGKATKAN PRODUKSI ASI
Authors: Miraturrofi’ah Mira 
Published: October 2022

Latar Belakang : Air Susu Ibu (ASI) adalah sumber gizi dan makanan paling aman serta ideal bagi bayi usia 0-6 bulan. ASI mengandung hampir 200 unsur zat makanan. WHO merekomendasikan pemberian ASI selama minimal 6 bulan. UNICEF memastikan bahwa bayi yang diberi susu formula memiliki kemungkinan meninggal pada bulan pertama sebesar 25 kali lebih besar dibandingkan bayi yang diberi ASI eksklusif. Dalam pelaksanaannya pemberian ASI eksklusif tidak selalu lancar. Penelitian di Australia mengemukakan bahwa 29% ibu nifas berhenti memberikan ASI akibat produksi ASI menurun. Penurunan ASI pada hari-hari pertama setelah melahirkan dapat disebabkan kurangnya stimulasi hormon prolaktin dan oksitosin yang berperan penting dalam kelancaran produksi ASI.
Tujuan penelitian ini adalah membandingkan terapi komplementer Tuina Akupoin dan Facial Loving Touch (FLT) dalam meningkatkan produksi ASI.
Metode : Penelitian comparative design dengan rancangan two group pretest and posttest design. Pretest dilakukan melalui pengukuran produksi ASI dengan pumping elektrik selama 5 menit. Kemudian dilakukan intervensi. Grup I diberikan intervensi Tuina Akupoint, sementara Grup II diberikan intervensi FLT. Lama intervensi setiap kelompok 20 menit. Pengelompokan didasarkan pada responden mana memenuhi kriteria inklusi terlebih dahulu. Posttest dilakukan dengan mengukur produksi ASI selama 5 menit.
Hasil : Kedua intervensi efektif meningkatkan produksi ASI (p-value Grup I = 0.000 < 0.05 & Grup II = 0.000 < 0.05), namun kelompok intervensi Tuina Akupoint memiliki nilai rata-rata produksi ASI lebih besar yaitu 8.0 dibandingkan kelompok intervensi FLT 4.05.
Simpulan : Terapi komplementer Tuina Akupoint dapat dijadikan salah satu alternativ dalam meningkatkan produksi ASI.
SKRINING PERKEMBANGAN ANAK USIA 5 – 6 TAHUN DENGAN KUESIONER PRA SKRINING PERKEMBANGAN (KPSP)
Authors: Barbara Maria A.D 
Published: October 2022

Perkembangan anak merupakan sebuah proses kontinu yang terjadi sejak masa konsepsi hingga dewasa. Berdasarkan studi pendahuluan yang dilakukan di RA ( Raudhatul athfal ) Ath-Thohiriyah terdapat 7 dari 10 orang anak yang masih belum bisa menggambar orang dengan minimal memuat 6 bagian tubuh, menyebutkan jenis-jenis warna, mengetahui fungsi benda, dan masih belum mengenali beberapa kata sifat benda. Menurut Kepala Sekolah RA Ath-Thohiriyah, diketahui bahwa di RA tersebut belum pernah dilakukan test deteksi dini tumbuh kembang. Penelitian ini bertujuan untuk mengetahui bagaimana perkembangan anak usia 5 – 6 tahun di RA Ath-Thohiriyah Cililin Tahun 2021. Rancangan penelitian ini menggunakan metode deskriptif. Sampel yang digunakan yaitu anak usia 5 – 6 tahun di RA Ath-Thohiriyah Cililin beserta ibu/pengasuhnya sebanyak 41 orang. Pengambilan sampel dalam penelitian ini menggunakan total sampling. Data yang digunakan yaitu data primer dengan menggunakan KPSP. Analisis data menggunakan univariat dalam bentuk presentase. Kategori perkembangan sesuai sebanyak (32%), kategori perkembangan meragukan sebanyak (36%), dan kategori perkembangan penyimpangan sebanyak (32%). Hampir setengahnya responden berada dalam kategori perkembangan meragukan.
PERAN KELUARGA DALAM MERAWAT ANGGOTA KELUARGA YANG MENDERITA TB PARU DI RUANGAN SANTO IGNATIUS RUMAH SAKIT SANTA ELISABETH MEDAN
Authors: Situmorang Teresia , Derang Imelda , Sirait Imelda , Simorangkir Lindawati 
Published: October 2022

Tuberkulosis paru adalah penyakit yang dapat ditularkan langsung melalui kuman TB (Mycobacterium tuberculosis), dan menjadi krisis di seluruh dunia sehingga dilakukanlah suatu program pengendalian yang disponsori Nasional (RNTCP). Hal ini yang paling berperan adalah keluarga, berupa dukungan fisik dan fsikologis dalam merawat anggota keluarga. Penelitian ini bertujuan guna mengulas lebih jauh peran keluarga dalam merawat anggota keluarga yang sedang menderita penyakit TB paru. Adapun metodologi penelitian yang akan digunakan dalam penelitian ini adalah dengan menggunakan metode kualitatif fenomenologis, yang mana dalam penelitian ini pula terdiri dari 6 orang informan yang berasal dari keluarga inti dengan ketentuan terdapat anggota keluarga yang menderita TB paru tersebut. Dari hasil penelitian diperoleh 6 thema yaitu 1) Pengetahuan keluarga, tingkat keseriusan, dan penularan, 2) Hambatan keluarga, 3) Keyakinan keluarga, 4) Dukungan keluarga dan Kesehatan setempat 5) Pendampingan, pemenuhan nutrisi, dan pengawasan 6) Pemahaman keluarga mengenai lingkungan sehat. Hal ini diakibatkan karena keluarga belum memahami penularan dai TB paru, kurang ekonomi, waktu dan pengetahuan, kurangkanya informasi selama proses pengobatan, kurangnya pengawasan dalam pemberian obat dan gizi, serta keluarga tidak menyadari akan pentingnya lingkungan sehat. Berdasarkan hasil yang telah diperoleh tersebut, dapat disimpulkan bahwa kurangnya peran keluarga dalam merawat anggota keluarga yang menderita TB paru. Dari hasil tersebut dapat disimpulkan bahwa peran keluarga dalam merawat anggota keluarga TB paru kurang. Sehingga diharapkan lebih meningkatkan adanya pendampingan keluarga bagi anggota keluarga yang TB paru seperti memperhatikan gizi, mengawasi untuk minum obat, mengingatkan istirahat, menanyakan keluhan, menemani kontrol ke Puskesmas atau Rumah sakit agar tidak putus obat, serta memperhatikan lingkungan bersih dan sehat.
Three‐dimensional nanoporous activated carbon electrode derived from acacia wood for high‐performance supercapacitor
Authors: Hamouda Hamouda Adam , Abdu Hassan Idris , Hu Qinzheng , Abubaker Mohamed Aamer , Lei Haikuo , Cui Shuzhen , Alduma Anwar I. , Peng Hui , Ma Guofu , Lei Ziqiang 
Published: October 2022

Herein, the novel acacia wood based hierarchical porous activated carbons (AWCs) are easily prepared, low cost and have excellent characterization, such as special biomass nanopores via structural stability and large specific surface areas. Activating agents such as KOH, ZnCl2, and H3PO4 have been used to convert acacia wood carbon into active carbons such as AWC-K, AWC-Z, and AWC-P, respectively, which are named after the activating agent. As a supercapacitor electrode, the AWC-K sample has a high yield was 69.8%, significant specific surface area of 1563.43 m2g−1 and layer thickness of 4.6 mm. Besides that, it showed specific capacitance of 224.92 F g−1 at 0.5 A g−1 in 2 M KOH as electrolyte. In addition, the AWC-K//AWC-K symmetrical supercapacitor device displays high energy density of 23.98 Wh kg−1 at 450 W kg−1 power density with excellent cycling number stability was 93.2% long lifetime of 10,000 cycles using 0.5 M Na2SO4 as electrolyte. The high electrochemistry performance mainly contributed the special biomass pores structure. Therefore, the presented approach opens new avenues in supercapacitor applications to meet energy storage.
Changes in HDL cholesterol, particles, and function associate with pediatric COVID-19 severity
Authors: Mietus-Snyder Michele , Suslovic William , Delaney Meghan , Playford Martin P. , Ballout Rami A. , Barber John R. , Otvos James D. , DeBiasi Roberta L. , Mehta Nehal N. , Remaley Alan T. 
Published: October 2022

BackgroundMyriad roles for high-density lipoprotein (HDL) beyond atheroprotection include immunologic functions implicated in the severity of coronavirus disease-2019 (COVID-19) in adults. We explored whether there is an association between HDL and COVID-19 severity in youth.MethodsA pediatric cohort (N = 102), who tested positive for COVID-19 across a range of disease manifestations from mild or no symptoms, to acute severe symptoms, to the multisystem inflammatory syndrome of children (MIS-C) was identified. Clinical data were collected from the medical record and reserve plasma aliquots were assessed for lipoproteins by NMR spectroscopy and assayed for HDL functional cholesterol efflux capacity (CEC). Findings were compared by COVID-19 status and symptom severity. Lipoprotein, NMR spectroscopy and CEC data were compared with 30 outpatient COVID negative children.ResultsDecreasing HDL cholesterol (HDL-c), apolipoprotein AI (ApoA-I), total, large and small HDL particles and HDL CEC showed a strong and direct linear dose-response relationship with increasing severity of COVID-19 symptoms. Youth with mild or no symptoms closely resembled the uninfected. An atypical lipoprotein that arises in the presence of severe hepatic inflammation, lipoprotein Z (LP-Z), was absent in COVID-19 negative controls but identified more often in youth with the most severe infections and the lowest HDL parameters. The relationship between HDL CEC and symptom severity and ApoA-I remained significant in a multiply adjusted model that also incorporated age, race/ethnicity, the presence of LP-Z and of GlycA, a composite biomarker reflecting multiple acute phase proteins.ConclusionHDL parameters, especially HDL function, may help identify youth at risk of more severe consequences of COVID-19 and other novel infectious pathogens.
Blastocyst quality and perinatal outcomes of frozen-thawed single blastocyst transfer cycles
Authors: Jia Nan , Hao Haoying , Zhang Cuilian , Xie Juanke , Zhang Shaodi 
Published: October 2022

ObjectiveTo investigate the effects of blastocyst quality and morphological grade on the perinatal outcomes in patients undergoing frozen-thawed single blastocyst transfer cycles.MethodsThis single-center retrospective cohort study included 2648 singleton neonates resulting from frozen-thawed single blastocyst transfers performed between January 2017 and September 2021. Multivariate logistic regression was performed to evaluate perinatal outcomes for their association with blastocyst quality and morphological parameters.ResultTransfer of a good-quality blastocyst in a frozen-thawed cycle was associated with a lower rate of preterm delivery (PTD, adjusted OR =0.7, 95% CI 0.5-0.9; P=0.020) and a higher likelihood of a male neonate (adjusted OR =1.2, 95%CI 1.0-1.5; P=0.048). Compared with grade C inner cell mass (ICM) blastocyst transfer, grade B ICM (adjusted OR =0.5, 95%CI 0.2-0.9; P=0.027) and grade A ICM (adjusted OR =0.6, 95%CI 0.3-1.5; P=0.290) blastocyst transfers were associated with a lower rate of PTD, which was more evident for grade B ICM. After adjusting for confounders, the likelihood of a male neonate (grade B TE, OR =1.2, 95%CI 1.0-1.5, P=0.037; grade A TE OR =1.9, 95%CI 1.3-28, P=0.002) increased with increasing trophectoderm (TE) quality. Compared with expansion stage 4, the likelihood of a male neonate was 1.5 times greater with transfer of a stage 6 blastocyst (OR =1.5, 95%CI 1.0-2.3; P=0.06), and the risk of small for gestational age (SGA) was greater with transfer of a stage 5 blastocyst (adjusted OR =3.5, 95%CI 1.5-8.0; P=0.004). The overall grading of the blastocyst, expansion stage, ICM grade, and TE grade were not associated with length at birth, birthweight, large for gestational age (LGA), or birth defects (all P&gt;0.05).ConclusionsIn frozen-thawed single blastocyst transfer cycles, transfer of a good-quality blastocyst was associated with a lower rate of PTD and a greater likelihood of a male neonate. Transfer of grade B ICM blastocysts decreased the rate of PTD, and TE quality was positively correlated with the likelihood of a male neonate.
PRDX6AS1 gene polymorphisms and SLE susceptibility in Chinese populations
Authors: Zhang Xiao-Xue , You Jun-Peng , Liu Xin-Ran , Zhao Ya-Fei , Cui Yan , Zhao Zhan-Zheng , Qi Yuan-Yuan 
Published: October 2022

BackgroundSystemic lupus erythematosus (SLE) is a complex, multisystem autoimmune disease that is characterized by the production of autoantibodies. Although accumulated evidence suggests that the dysregulation of long non-coding RNAs (lncRNAs) is involved in the pathogenesis of SLE, the genetic contributions of lncRNA coding genes to SLE susceptibility remain largely unknown. Here, we aimed to provide more evidence for the role of lncRNA coding genes to SLE susceptibility.MethodsThe genetic association analysis was first adopted from the previous genome-wide association studies (GWAS) and was then validated in an independent cohort. PRDX6-AS1 is located at chr1:173204199-173446294. It spans a region of approximately 240 kb, and 297 single nucleotide polymorphisms (SNPs) were covered by the previous GWAS. Differential expression at the mRNA level was analyzed based on the ArrayExpress Archive database.ResultsA total of 33 SNPs were associated with SLE susceptibility, with a P&lt;1.68×10-4. The strongest association signal was detected at rs844649 (P=2.12×10-6), according to the previous GWAS. Combining the results from the GWAS Chinese cohort and our replication cohort, we pursued a meta-analysis approach and found a pronounced genetic association between PRDX6-AS1 rs844649 and SLE susceptibility (pmeta=1.24×10-13, OR 1.50, 95% CI: 1.34–1.67). The mRNA expression of PRDX6 was elevated in peripheral blood cells, peripheral blood mononuclear cells (PBMCs), and multiple cell subpopulations, such as B cells, CD4+ T cells, CD3+ cells, and monocytes in patients with SLE. The PRDX6 protein expression level was also increased in patients with SLE compared with healthy donors.ConclusionOur study provides new evidence that variants located in lncRNA coding genes are associated with SLE susceptibility.
Comparison of clinical characteristics between SARS-CoV-2 Omicron variant and Delta variant infections in China
Authors: Li Qinggang , Liu Xiaorui , Li Lei , Hu Xiaobo , Cui Guangying , Sun Ranran , Zhang Donghua , Li Juan , Li Yonghong , Zhang Yong , Shen Shen , He Ping , Li Shasha , Liu Yanmin , Yu Zujiang , Ren Zhigang 
Published: October 2022

BackgroundThe continued ‘evolution’ of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the emergence of the Omicron variant after the Delta variant, resulting in a significant increase in the number of people with COVID-19. This increase in the number of cases continues to have a significant impact on lives. Therefore, a more detailed understanding of the clinical characteristics of Omicron infection is essential.MethodsUsing medical charts, we extracted clinical information for 384 patients infected with the Omicron variant in Anyang City, Henan Province, China. Epidemiology and clinical characteristics were compared with a cohort of people infected with the Delta variant in Zhengzhou in 2021.FindingsCommon initial symptoms at onset of illness were cough [240 (63%)], expectoration [112 (29%)], fever [96 (25%)], nasal congestion [96 (25%)] and myalgia or fatigue [30 (6%)]. In patients with the Omicron variant, levels of total cholesterol, low-density lipoprotein and creatinine increased in 52 (14%), 36 (9%) and 58 (15%) patients, respectively, compared with patients with the Delta variant [one (1%), one (1%) and two (2%)]. Levels of triglyceride and high-density lipoprotein also increased. In patients with the Omicron variant, the levels of specific gravity and the erythrocyte sedimentation rate were increased in 115 (30%) and 81 (21%) patients, and serum levels of complement 3 decreased in 93 (41%).ResultsCompared with patients infected with Delta, no major differences in initial clinical symptoms were identified in patients infected with Omicron. However, dyslipidemia and kidney injury were much more severe in patients with the Omicron variant, and the erythrocyte sedimentation rate was increased. Due to decreased levels of complement 3, the immunity of patients with the Omicron variant was weak.
Characteristics of initial symptoms in patients with dementia with Lewy body disease
Authors: Fei Min , Wang Fei , Wu Hao , Liu Shuai , Gan Jinghuan , Ji Yong 
Published: October 2022

BackgroundDementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia. Although DLB is characterized by fluctuating cognitive impairment, some symptoms may appear before cognitive impairment, including rapid eye movement, sleep behavior disorder (RBD), psychiatric symptoms, autonomic symptoms, Parkinson's symptoms, etc. Therefore, DLB may be misdiagnosed as other diseases in its early stage.ObjectiveThis study aimed to investigate the characteristics of initial symptoms of DLB, which could potentially offer essential clues for the earliest diagnosis of this disorder.MethodsA total of 239 patients with probable DLB who visited the cognitive impairment outpatient department of Tianjin Huanhu Hospital from September 2015 to March 2021 were consecutively enrolled. We retrospectively evaluated the initial symptoms of all included participants. The time of onset of initial symptoms was also assessed.ResultsThe most frequent initial symptom was memory loss (53.9%), followed by psychiatric symptoms (34.7%), RBD (20.9%), parkinsonism (15.1%), and autonomic symptoms (10.1%). Significant gender and age differences existed in the initial symptoms of patients with DLB.ConclusionsOur study elucidated the initial symptoms in patients with probable DLB. RBD was significantly more reported by men than by women, whereas women showed a higher incidence of visual and auditory hallucinations. A better understanding of the initial symptoms of DLB could lead to a more accurate diagnosis.
Worldwide Meniere's disease research: A bibliometric analysis of the published literature between 2002 and 2021
Authors: Zou Wujun , Li Qian , Peng Fei , Huang Dingqiang 
Published: October 2022

BackgroundIn recent years, there has been an increasing number of publications on Meniere's disease. However, there are no bibliometric research on Meniere's disease. The purpose of this study was to find the focus and trends of Meniere's disease research through bibliometric approach.MethodsPublications related to Meniere's disease in the Web of Science Core Collection (WOSCC) from 2002 to 2021 were collected. The bibliometric approach was used to estimate the searched data. Research foci of the studies were identified using VOSviewer and CiteSpace software.ResultsA total of 1,987 articles meet the inclusion criteria and are included in the study. In the past 20 years, the number of Meniere's disease publications is gradually increasing, especially in the past 3 years. The country with the largest contribution to Meniere's disease research is the United States, followed by Europe and Japan. High-frequency keywords included Meniere's disease, endolymphaic hydrops, vertigo, meniere-disease, inner ear, dizziness, symptoms, hearing, diagnosis, and tentamicin. The analyses of keyword burst direction indicate that evoked myogenic potential, MRI, and committee are emerging research hotspots.ConclusionThis study provides an objective, systematic, and comprehensive analysis of Meniere's disease-related literature. In addition, we find a dramatic increase in studies in this field over the past 3 years. Evoked myogenic potentials and MRI may become the research hotspots of Meniere's disease in future. This study will help otolaryngologists, neurologists, and audiologists to clarify the research direction and potential hotspots of Meniere's disease and further help clinicians improve patients' prognosis.