bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions About Biosimilar Medicines Among Belgian Patients in the Ambulatory Care
Authors: Vandenplas Yannick , Barbier Liese , Simoens Steven , Van Wilder Philippe , Vulto Arnold G. , Huys Isabelle 
Published: January 2022

Background and objectives: Biosimilar medicines have been on the European market for 15 years. Despite the extensive and positive experience with biosimilars across Europe, their uptake remains limited in Belgium. One of the possible factors limiting uptake in clinical practice is the inadequate understanding and lack of trust in biosimilars among patients. This study aimed to assess the level of knowledge and perceptions about biosimilar medicines among Belgian patients in the ambulatory care.Methods: This study consisted of online questionnaires among Belgian patients in the ambulatory care (i.e., rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, plaque psoriasis, Crohn’s disease, ulcerative colitis, diabetes mellitus type I and II). The results were collected between December 2020 and February 2021. The data were analyzed with descriptive and inferential statistics.Results: In total, 657 patients across all disease areas of interest participated in this study. Only 38% of patients had heard of biosimilars before. Of those patients, most (58%) were aware that biosimilars are as safe and effective as their reference product. The vast majority of respondents (68%) would agree with transitioning to a biosimilar if their physician prescribed it, only 3% would never agree with a transition to a biosimilar. If a physician would propose to change their current originator biological therapy with its biosimilar, nearly all patients (95%) want their physician to explain the decision and inform them. For additional information about biosimilars, Belgian patients prefer brochures or folders (41%), or available resources on the internet (35%). Physicians were indicated as the preferred source of information (95%), followed by pharmacists (51%), academia (39%), and patient associations (35%). Most patients require information regarding the safety and efficacy (78%), price and reimbursement (64%), and the clinical development process (56%) of the biosimilar.Conclusion: Belgian patients require information about biosimilar medicines. However, most patients are open and positive towards transitioning their current biological therapy with its biosimilar if sufficiently supported by their healthcare providers.
Biphasic Effect of Pirfenidone on Angiogenesis
Authors: Gan Donghao , Cheng Wenxiang , Ke Liqing , Sun Antonia RuJia , Jia Qingyun , Chen Jianhai , Xu Zhanwang , Xu Juan , Zhang Peng 
Published: January 2022

Pirfenidone (PFD), a synthetic arsenic compound, has been found to inhibit angiogenesis at high concentrations. However, the biphasic effects of different PFD concentrations on angiogenesis have not yet been elucidated, and the present study used an in vitro model to explore the mechanisms underlying this biphasic response. The effect of PFD on the initial angiogenesis of vascular endothelial cells was investigated through a Matrigel tube formation assay, and the impact of PFD on endothelial cell migration was evaluated through scratch and transwell migration experiments. Moreover, the expression of key migration cytokines, matrix metalloproteinase (MMP)-2 and MMP-9, was examined. Finally, the biphasic mechanism of PFD on angiogenesis was explored through cell signaling and apoptosis analyses. The results showed that 10–100 μM PFD has a significant and dose-dependent inhibitory effect on tube formation and migration, while 10 nM–1 μM PFD significantly promoted tube formation and migration, with 100 nM PFD having the strongest effect. Additionally, we found that a high concentration of PFD could significantly inhibit MMP-2 and MMP-9 expression, while low concentrations of PFD significantly promoted their expression. Finally, we found that high concentrations of PFD inhibited EA.hy926 cell tube formation by promoting apoptosis, while low concentrations of PFD promoted tube formation by increasing MMP-2 and MMP-9 protein expression predominantly via the EGFR/p-p38 pathway. Overall, PFD elicits a biphasic effect on angiogenesis through different mechanisms, could be used as a new potential drug for the treatment of vascular diseases.
The Estimation of Critical Angle in Climbing as a Measure of Maximal Metabolic Steady State
Authors: Baláš Jiří , Gajdošík Jan , Giles David , Fryer Simon 
Published: January 2022

Purpose: Sport climbing is a technical, self-paced sport, and the workload is highly variable and mainly localized to the forearm flexors. It has not proved effective to control intensity using measures typical of other sports, such as gas exchange thresholds, heart rate, or blood lactate. Therefore, the purposes of the study were to (1) determine the possibility of applying the mathematical model of critical power to the estimation of a critical angle (CA) as a measure of maximal metabolic steady state in climbing and (2) to compare this intensity with the muscle oxygenation breakpoint (MOB) determined during an exhaustive climbing task.Materials and Methods: Twenty-seven sport climbers undertook three to five exhaustive ascents on a motorized treadwall at differing angles to estimate CA, and one exhaustive climbing test with a progressive increase in angle to determine MOB, assessed using near-infrared spectroscopy (NIRS).Results: Model fit for estimated CA was very high (R2 = 0.99; SEE = 1.1°). The mean peak angle during incremental test was −17 ± 5°, and CA from exhaustive trials was found at −2.5 ± 3.8°. Nine climbers performing the ascent 2° under CA were able to sustain the task for 20 min with perceived exertion at 12.1 ± 1.9 (RPE). However, climbing 2° above CA led to task failure after 15.9 ± 3.0 min with RPE = 16.4 ± 1.9. When MOB was plotted against estimated CA, good agreement was stated (ICC = 0.80, SEM = 1.5°).Conclusion: Climbers, coaches, and researchers may use a predefined route with three to five different wall angles to estimate CA as an analog of critical power to determine a maximal metabolic steady state in climbing. Moreover, a climbing test with progressive increases in wall angle using MOB also appears to provide a valid estimate of CA.
Effects of Olympic Combat Sports on Health-Related Quality of Life in Middle-Aged and Older People: A Systematic Review
Authors: Valdés-Badilla Pablo , Herrera-Valenzuela Tomás , Guzmán-Muñoz Eduardo , Delgado-Floody Pedro , Núñez-Espinosa Cristian , Monsalves-Álvarez Matias , Andrade David Cristóbal 
Published: January 2022

Olympic combat sports are unconventional physical activity strategies to train middle-aged and older people with and without health problems. This systematic review aimed to assess the available body of published peer-reviewed articles related to the effects of Olympic combat sports interventions (boxing, fencing, judo, karate, taekwondo, wrestling) on health-related quality of life in adults aged 45 and older. The search was carried out in five generic databases until July 2021 and the protocol was registered in PROSPERO (code: CRD42021244161). The PRISMA guidelines were followed and the Downs and Black checklist was used to assessed the methodological quality of the studies. After reviewing 1,151 records, only seven studies met the inclusion criteria, adding 212 participants (43.4% female) with a mean age of 63.7 years. Six studies (two with middle-aged participants and four with older people) provided data to calculate the effect size (ES) in the Olympic combat sports groups (No research that used taekwondo or wrestling as an intervention modality was found). Three studies reported beneficial changes with a small ES for the total score (d &lt; 0.40) of the health-related quality of life. Two studies reported a beneficial change with a small ES (d = 0.49) and strong ES (d = 4.45) for physical health. One study reported improvements with a small ES for emotional (d = 0.23) and functional (d = 0.26) well-being. In conclusion, interventions based on Olympic combat sports produce beneficial effects with a small and moderate ES on health-related quality of life in male and female aged 45 and older who are healthy participants, participants with Parkinson's disease, and participants with breast cancer.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, PROSPERO: CRD42021244161.
Comparison of Characteristics of Suicide Attempts Registered in Urban and Rural Areas in China
Authors: Li Lingling , Liu Chunxu , Tong Yongsheng , Wu Jianlan , Zhou Wei , Yin Yi , Wu Mengjie , Tong Ruoyang , An Jing 
Published: January 2022

Objective: The objective of this study is to compare the characteristics of suicide attempts registered in general hospitals in urban and rural areas in China.Methods: From January 2007 to December 2011, suicide attempts registered in hospitals in five rural counties and in the Beijing Municipality were included. Univariate and multivariate analysis were used to compare the characteristics of rural and urban suicide attempts in China.Results: A total of 5,515 episodes of suicide attempts were included, 1,966 (35.6%) of them were from rural counties and 3,549 (64.4%) were from Beijing. Compared with urban counterparts, the rural suicide attempters had lower proportion of females (61.9% vs. 72.3%), more likely reporting previous suicide attempt history (56.9% vs. 16.4%), and staying in hospital for more than 1 day (81.5% vs. 44.6%). The most common methods of suicide attempts were pesticide ingestion in rural areas (52.1%) and taking medications in urban area (39.2%). Results of multivariate analysis indicated that suicide attempt registered in rural areas, pesticide ingestion, and previous suicide attempts history were associated with longer treatment in hospitals.Conclusions: Suicide attempts registered in rural areas were different from those in urban areas in China. It is essential to improve the equipment and ability of medical resuscitation for pesticide ingestion in rural hospitals in China.
Examining Cannabis, Tobacco, and Vaping Discourse on Reddit: An Exploratory Approach Using Natural Language Processing
Authors: Benson Ryzen , Hu Mengke , Chen Annie T. , Zhu Shu-Hong , Conway Mike 
Published: January 2022

Background: Perceptions of tobacco, cannabis, and electronic nicotine delivery systems (ENDS) are continually evolving in the United States. Exploring these characteristics through user generated text sources may provide novel insights into product use behavior that are challenging to identify using survey-based methods. The objective of this study was to compare the topics frequently discussed among Reddit members in cannabis, tobacco, and ENDS-specific subreddits.Methods: We collected 643,070 posts on the social media site Reddit between January 2013 and December 2018. We developed and validated an annotation scheme, achieving a high level of agreement among annotators. We then manually coded a subset of 2,630 posts for their content with relation to experiences and use of the three products of interest, and further developed word cloud representations of the words contained in these posts. Finally, we applied Latent Dirichlet Allocation (LDA) topic modeling to the 643,070 posts to identify emerging themes related to cannabis, tobacco, and ENDS products being discussed on Reddit.Results: Our manual annotation process yielded 2,148 (81.6%) posts that contained a mention(s) of either cannabis, tobacco, or ENDS with 1,537 (71.5%) of these posts mentioning cannabis, 421 (19.5%) mentioning ENDS, and 264 (12.2%) mentioning tobacco. In cannabis-specific subreddits, personal experiences with cannabis, cannabis legislation, health effects of cannabis use, methods and forms of cannabis, and the cultivation of cannabis were commonly discussed topics. The discussion in tobacco-specific subreddits often focused on the discussion of brands and types of combustible tobacco, as well as smoking cessation experiences and advice. In ENDS-specific subreddits, topics often included ENDS accessories and parts, flavors and nicotine solutions, procurement of ENDS, and the use of ENDS for smoking cessation.Conclusion: Our findings highlight the posting and participation patterns of Reddit members in cannabis, tobacco, and ENDS-specific subreddits and provide novel insights into aspects of personal use regarding these products. These findings complement epidemiologic study designs and highlight the potential of using specific subreddits to explore personal experiences with cannabis, ENDS, and tobacco products.
Incentive Preferences and Its Related Factors Among Primary Medical Staff in Anhui Province, China: A Cross-Sectional Study
Authors: Sang Lingzhi , Liu Hongzhang , Yan Huosheng , Rong Jian , Cheng Jing , Wang Li , Li Guoqiang , Guo Yan , Zhang Lei , Ding Hong , Chen Guimei , Chen Ren 
Published: January 2022

Background: The shortage of primary medical staff is a major problem in the management of health human resources across many developing countries. By determining their preferences for various motivational and related factors, we examined the correlation between staff's motivation preference levels and staff turnover and turnover intention. This study aimed to further improve the incentive mechanism and to provide a reference for healthcare managers to formulate management strategies for the primary medical staff team.Methods: A self-reported questionnaire survey was conducted to collect data. The basic survey content included demographic characteristics. The absolute level questionnaire and relative level questionnaire on the factors affecting motivation preference were used as the main assessment scales. A total of 1,112 primary health workers in Anhui Province were investigated. T-test, analysis of variance (ANOVA), exploratory factor analysis, and multiple linear regression analysis were performed to analyze the data.Results: The survey respondents (45.1%) reported being satisfied with their relationship with colleagues, and other social relationships (46.9%). The Kaiser Meyer Olkin (KMO) value for the absolute preference degree for motivational factors was 0.951. Two factors (economic and non-economic factors), after using the maximum variance rotation axis method, explained 81.25% of the total variance. The regression analysis showed that primary medical staff members with low monthly income (B = −0.157) have a higher preference for non-economic factors; the higher the educational background (B = 0.133), the higher their preference for economic factors. In addition, with the increase in participants' age (B = −0.250), the preference for motivational factors gradually decreased.Conclusion: Both economic and non-economic factors play an important role in enhancing the enthusiasm of primary medical workers and improving their work attitude. Managers should use their influence to stabilize the primary medical staff.
Resuscitation Patterns and Massive Transfusion for the Critical Bleeding Dog—A Multicentric Retrospective Study of 69 Cases (2007–2013)
Authors: Tucker Claire , Winner Anna , Reeves Ryan , Cooper Edward S. , Hall Kelly , Schildt Julie , Brown David , Guillaumin Julien 
Published: January 2022

Objective:To describe resuscitation patterns of critically bleeding dogs, including those receiving massive transfusion (MT).Design:Retrospective study from three universities (2007–2013).Animals:Critically bleeding dogs, defined as dogs who received ≥ 25 ml/kg of blood products for treatment of hemorrhagic shock caused by blood loss.Measurements and Main Results:Sixty-nine dogs were included. Sources of critical bleeding were trauma (26.1%), intra/perioperative surgical period (26.1%), miscellaneous (24.6%), and spontaneous hemoabdomen (23.1%). Median (range) age was 7 years (0.5–18). Median body weight was 20 kg (2.6–57). Median pre-transfusion hematocrit, total protein, systolic blood pressure, and lactate were 25% (10–63), 4.1 g/dl (2–7.1), 80 mm Hg (20–181), and 6.4 mmol/L (1.1–18.2), respectively. Median blood product volume administered was 44 ml/kg (25–137.4). Median plasma to red blood cell ratio was 0.8 (0–4), and median non-blood product resuscitation fluid to blood product ratio was 0.5 (0–3.6). MT was given to 47.8% of dogs. Survival rate was 40.6%. The estimated odds of survival were higher by a factor of 1.8 (95% CI: 1.174, 3.094) for a dog with 1 g/dl higher total protein above reference interval and were lower by a factor of 0.6 (95% CI: 0.340, 0.915) per 100% prolongation of partial thromboplastin time above the reference interval. No predictors of MT were identified.Conclusions:Critical bleeding in dogs was associated with a wide range of resuscitation patterns and carries a guarded to poor prognosis.
Educação física e pandemia: o que dizem alguns estudos sobre o ensino remoto de educação física na educação básica?
Authors: Barbosa Kamila de Amorim , Damasceno Aline Godoy , Antunes Scheila Espindola 
Published: January 2022

INTRODUÇÃO: Com as novas formas de interação social impostas pela pandemia da Covid-19 todos os segmentos sociais sofreram alterações. Dentre eles, a educação pode ser classificada como um dos mais afetados, tendo em vista que até o momento muitos estados brasileiros ainda não conseguiram retomar suas atividades presenciais. Nesse contexto de ensino remoto, como estão sendo desenvolvidas as atividades da educação física? Como os conteúdos práticos são tratados nas aulas remotas? Os alunos estão participando das aulas? Mobilizadas por essas e outras questões elaboramos um estudo de levantamento bibliográfico. OBJETIVO: Conhecer produções acadêmicas sobre o ensino remoto de educação física publicadas durante o primeiro ano de pandemia da Covid-19. MÉTODOS: Busca online por textos de cunho acadêmico publicados em língua portuguesa no período de março/2020 a março/2021. A ferramenta de busca foi o google acadêmico. As análises foram realizadas com base nos critérios: tipo de produção; objeto de análise/discussão; principais resultados dos trabalhos. RESULTADOS: Foram analisados dois relatos de experiência, três pesquisas bibliográficas e nove pesquisas empíricas. Os textos apresentam dados e/ou reflexões sobre dificuldades encontradas pelos professores durante o ensino remoto; estados de humor/ansiedade/estresse dos alunos; experiências didáticas no ensino remoto de educação física. CONCLUSÃO: Os estudos apontam baixa participação dos alunos nas aulas remotas; falta de preparo dos professores para trabalhar com as novas tecnologias; aumento nos níveis de ansiedade e estresse dos alunos; falta de elementos estruturantes para as aulas.
Angażowanie użytkowników w proces projektowania stron internetowych i aplikacji mobilnych za pomocą platform crowdsourcingowych
Authors: Gil Andrzej 
Published: January 2022

Cel/Teza: Celem artykułu jest analiza i omówienie dostępnych narzędzi crowdsourcingowych używanych na poszczególnych etapach procesu projektowego stron internetowych i aplikacji mobilnych. Praca stanowi omówienie i opracowanie dostępnych metod angażowania użytkownika i sygnalizuje efekty wynikające z takiej współpracy.
Koncepcja i metody badawcze: Ze względu na dynamiczny rozwój samego crowdsourcingu, poszczególne techniki angażowania użytkowników zostały zebrane przez autora na podstawie kompleksowej analizy piśmiennictwa naukowego i branżowego (w tym serwisów internetowych dla praktyków dziedzinowych), podręczników oraz raportów komercyjnych. Platformy crowdsourcingowe wykorzystywane w procesie projektowania, ze względu na swój praktyczny charakter, zostały ponadto opatrzone przykładami implementacji, w celu lepszego wyjaśnienia ich funkcjonowania.
Wyniki i wnioski: Dostępne platformy crowdsourcingowe obecne są na każdym z etapów projektowania aplikacji mobilnych i stron internetowych – stanowią kopalnię pomysłów i opłacalne rozwiązanie z ekonomicznego punktu widzenia. W większości koncentrują się one tylko na podsuwaniu nieustrukturyzowanych sugestii i walidacji wdrożonych już rozwiązań. Crowdsourcing w niewielkim stopniu wykorzystuje się przy faktycznym budowaniu narzędzi cyfrowych. Autor zlokalizował jednak, istniejące już teraz przykłady angażowania użytkowników w proces projektowania produktów i usług cyfrowych, które w najbliższej przyszłości mogą przeobrazić się w rozwiązania crowdsourcingowe.
Oryginalność/Wartość poznawcza: Zgodnie z wiedzą autora, przedstawiony temat nie był jeszcze opracowany w piśmiennictwie zarówno polskim, jak i międzynarodowym. Artykuł jest pierwszą próbą holistycznej analizy i sklasyfikowania poszczególnych narzędzi crowdsourcingowych wykorzystywanych w praktyce projektowania produktów i usług cyfrowych.
HUBUNGAN COPING STRES DAN DUKUNGAN SOSIAL DENGAN STRES AKADEMIK PADA PEMBELAJARAN JARAK JAUH
Authors: Dewi Diana Lilik Kusumawati , Muslikah Muslikah 
Published: January 2022

Penelitian ini membahas mengenai hubungan antara coping stress dan dukungan sosial dengan stres akademik pada pembelajaran jarak jauh siswa kelas X SMA Negeri se-Kecamatan Ngaliyan Semarang. Tujuan pada penelitian ini yakni untuk mengetahui hubungan antar variabel dan memperoleh informasi tingkat masing-masing variabel dengan sampel sebanyak 255 siswa. Metode dalam penelitian ini adalah kuantitatif berjenis ex-post facto. Hasil analisis deskriptif menunjukkan bahwa tingkat coping stress siswa kelas X SMA Negeri se-Kecamatan Ngaliyan Semarang pada kategori rendah (M=2,56), tingkat dukungan sosial tinggi (M=3,04), serta tingkat stress akademik pada pembelajaran jarak jauh tinggi (M=2,67). Hasil dari analisis regresi ganda menunjukkan bahwa terdapat hubungan yang negatif dan signifikan yakni antara coping stress dengan stress akademik pada pembelajaran jarak jauh siswa (t=-10,854, ?=-0,646, p=<0,05), dukungan sosial tidak terdapat hubungan yang signifikan dengan stres akademik pada pembelajaran jarak jauh siswa (t=-0,908, ?=-0,054, p=>0,05), dan terdapat hubungan yang positif dan signifikan antara coping stress dan dukungan sosial secara simultan terhadap stres akademik pada pembelajaran jarak jauh siswa (R= 0,681; R²= 0,464; F=109,083, p=<0,05). Berlandaskan hasil penelitian, diharapkan guru BK dapat memberi layanan bimbingan dan konseling untuk dapat menurunkan tingkat stres akademik siswa baik secara individu maupun kelompok, meningkatkan tingkat coping stress siswa serta layanan untuk mempertahankan tingkat dukungan sosial siswa
Factors Affecting Financial Behaviors:
Authors: Adriani Jean 
Published: January 2022

This study was conducted to determine the effect of financial knowledge, financial attitude, locus of control, risk tolerance, motivation, and mental accounting on financial behavior. The population was 168 students majoring in International Business Management at Universitas Ciputra Surabaya. The characteristics of the respondents are students who are in the 6th semester and above at the time of taking the sampling with purposive sampling method. The data obtained were analyzed using Partial Least Square (PLS). The result shows that the factors of financial knowledge, locus of control, motivation, have no effect on financial behavior. While the factors of financial attitude, risk tolerance, and mental accounting have an effect on financial behavior.
THE INFLUENCE OF WORK ABILITY, WORK ETHOS AND WORK ENVIRONMENT ON EMPLOYEE PERFORMANCE AT GARMENT INDUSTRIES IN JOMBANG INDONESIA
Authors: Kurniawati Novi , Siti Mujanah  
Published: January 2022

The purpose of this study was to determine the effect of work ability, work ethic and work environment on employee performance. This study usesquantitative methods. Total population and samples are 50 respondents from all employees Garment Industries. The data analysis technique used is Multiple Linear Regression Analysis. The t test results show that work ability, has a positive and significant effect on employee performance, work etnic has a positive and significant effect on employee performance, and work environment has a positive and significant effect on employee performance. And the results of the F show that the variables of Self Ability, work etnic and work environment simultaneously affect the Employee Performance OF Garmen Industries