bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Preparations К-26 and K-26-v on the Tumor Sarcoma 45 in the Early and Late Period in Comparison with Cisplatin and Cyclophosphan
Authors: Еникеева З.М. , Агзамова Н.А. , Абдирова А.Ч. , Ибрагимов А.А. , Салихов Ф.С. , Ярашева Н.И. , Саидходжаева С.С. , Рахимов О.А. , Тилляшайхов М.Н. 
Published: March 2022

Цель исследования. Оценка противоопухолевой активности новых препаратов К-26-в и К-26 на животных с опухолевым штаммом Саркома 45 в раннем и позднем периодах в сравнении с цисплатином и циклофосфаном.Материалы и методы. Изучение выполнено на 48 беспородных крысах с перевиваемой опухолью С-45, которым вводили препараты на 4-й или 14-й день после перевивки опухоли: К-26-в 4- и 8-кратно, К-26, цисплатин и циклофосфан вводили 8-кратно. Оценку результатов проводили по стандартным критериям: торможение роста опухоли (ТРО), масса тела и селезенки животных. Достоверными считали различия при р<0,05.Результаты. Противоопухолевая активность препаратов К-26-в и К-26 на опухолевом штамме Саркома 45 в раннем периоде была высокой – порядка 98/96% с уровнем ремиссий 80–60%. При лечении развившихся опухолей активность К-26-в была ниже, чем при раннем введении: при 4-кратном применении – 84/87%, при 8-кратном введении – 60/69%. Его эффект был выше действия К-26 и цисплатина и близок к эффекту циклофосфана, однако при снижении уровня побочных эффектов.Заключение. Изучение нового препарата К-26-в на животных с опухолью Саркома 45 выявило его высокую активность при лечении опухолей в раннем периоде, практически одинаковую с К-26. В позднем периоде активность К-26-в на 15–12% ниже, чем в раннем периоде, и выше в сравнении сисходным К-26, цисплатином и циклофосфаном. Выявлено, что 4-кратное применение К-26-в оказывает более значительное действие, которое будет предлагаться для клинических испытаний.Purpose. Assessment of antineoplastic activity of new preparation К-26-v on animals with tumoral strain Sarcoma 45 in the late period in comparison with cisplatin and cyclophosphan.Materials and methods. The study was conducted on 26 outbred rats with transplantable tumor С-45, to which the preparations were administered on the 14th day after transplantation of tumors: К-26-v – 4 and 8 times; К-26, cisplatin, and cyclophosphan – 8 times. Assessment of the results was conducted according to standard criteria: tumor growth inhibition (TGI), weight of the body and the spleen of animals. The reliable differences were considered the ones in р<0.05.Results. Antineoplastic activity of the preparation К-26-v on the tumoral strain Sarcoma 45 was high in the dose 12 mg/kg in 4-fold introduction: the level TGI=84/87%. Its action in 8-fold introduction was lower. Its effect was above the action of К-26 and cisplatin and close to the effect of cyclophosphan with decrease of side-effects.Conclusion. Studying the new preparation К-26-v on animals with the tumor Sarcoma 45 has revealed its more evident activity in comparison with initial К-26 and in comparison with cisplatin and cyclophosphan.
Effect of the New Antitumor Drug Colchicinol-2 (K-26-v) on the Immunity
Authors: Еникеева З.М. , Салихов Ф.С. , Ибрагимов А.А. , Мирахмедова Н.Н. , Залялиева М.В. 
Published: March 2022

Исследования воздействия на уровень и соотношение параметров иммунного статуса противоопухолевого препарата К-26-в были проведены в продуктивную фазу иммунного ответа после 8-кратного введения К-26-в животным с опухолью. Показано, что К-26-в вызывает стимуляцию рецепторов СD16 (естественные киллерные клетки) и СD3-лимфоцитов, кото-рые были несколько повышены относительно контроля, незначительную стимуляцию СD95 (рецепторы апоптоза). Не отмечено достоверных различий в экспрессии рецепторов СD19 (В-лимфоциты). Однако препарат К-26-в вызывает ингибицию рецепторов СD4 (хелперы) (р<0,05). В целом влияние на иммунитет, проявляющееся в некотором снижении рецепторов СD4, СD8 и СD19 препаратом К-26-в, не предполагает выраженного сбоя иммунитета при его применении в клинике.Researches of the influence of antineoplastic preparation К-26-v on the level and ratio of the parameters of the immune status were conducted in the productive phase of the immune response after 8-fold introduction of К-26-v to animals with tumor. It was showed that К-26-v causes stimulation of the receptors СD16 (natural killer cells) and СD3-lymphocytes that were a little raised in relation to the control, insignificant stimulation of СD95 (apoptosis receptors). There were no significant differences in the expression of the receptors СD19 (B-lymphocytes). However, the preparation К-26-v causes inhibition of the receptors СD4 (helpers) (р<0.05). Generally, the influence on the immunity, manifested in some decrease of the receptors СD4, СD8, and СD19 with the preparation К-26-v, does not imply the expressed failure of the immunity in its use in the clinic.
Clinical Aspects of Local Application of Ultralow Temperatures as a Method of Ablation of Liver and Pancreatic Malignancies (Literature Review)
Authors: Козачук Е.С. , Щигель И.А. , Стрилец Е.А. 
Published: March 2022

Сверхнизкие температуры в качестве локального метода абляции злокачественных новообразований успешно применяются во многих мировых клиниках в течение нескольких десятилетий. Данный метод получил название криогенной абляции, или криоабляции. Преимущества криогенной абляции: деструкция заданного объема патологического очага с четкой демаркацией зоны некроза и ее биологической инертностью, гемостаз, отсутствие выраженного болевого синдрома, безопасность применения в непосредственной близости к крупным кровеносным сосудам, противоопухолевая иммуностимуляция, возможность комбинированного применения с другими методами лечения, активная регенерация без формирования грубых рубцов, многократность циклов, простота в применении. Основным показанием к локальному применению сверхнизких температур при лечении злокачественных новообразований печени является циторедукция опухолевых очагов с целью локального контроля опухолевого роста, уменьшения стадии онкопроцесса, конверсии в резектабельное состояние и, как следствие, улучшения отдаленных результатов лечения пациентов, которые на момент обращения за специализированной медицинской помощью не подлежат радикальному хирургическому лечению.
Ultra-low temperatures, as a local method of malignant neoplasms ablation, have been successfully used in many clinics worldwide for several decades. This method is called cryogenic ablation or cryoablation. The advantages of cryogenic ablation are the following: destruction of appropriate volume of the pathological focus with the demarcation of the necrosis zone and its biologicalinertness, hemostasis, absence of pronounced pain syndrome, safety of use closely to large blood vessels, anti-tumor immunostimulation, possibility of combined use with other methods of treatment, active regeneration without formation of rough scars, multiple cycles, easy to use. The main indication for local application of ultra-low temperatures in treatment of malignant hepatic and pancreatic neoplasms is cytoreduction of tumor foci for local tumor control, reduction of the stage of the oncological process, conversion to resectable state, and, as a consequence, improvement of the 5-year survival of patients, who have contraindications for radical surgical treatment at time of medical care request.
Genetic Diversity of Hepatitis E Virus in the Republic of Belarus
Authors: Давыдов В.В. , Жаворонок С.В. , Анисько Л.А. , Гасич Е.Л. , Марчук С.И. , Семижон П.А. , Потемкин И.В. , Карлсен А.А. , Кюрегян К.К. , Михайлов М.И. , Алаторцева Г.И. , Красочко П.А. , Борисовец Д.С. , Прокопенкова Т.М. 
Published: March 2022

Целью настоящего исследования явилось изучение генетического полиморфизма штаммов вирусного гепатита Е (ВГЕ), выделенных из организма человека и животных в Республике Беларусь. Образцы биологического материала от 97 пациентов, 79 свиней, 28 диких кабанов, 40 оленей, 359 кроликов использовали для обнаружения РНК ВГЕ при помощи ПЦР-анализа. Выделенные нуклеотидные последовательности (n=9) подвергли процедуре секвенирования и филогенетическому анализу. Построена модель эволюционных отношений для последовательностей, кодирующих фрагмент белка капсида вируса. Изученные последовательности распределились по двум основным кладам субгенотипов 3-го генотипа вируса. В пределах клады«3abchij» кластеризуется 5 из 9 изученных последовательностей, а в кладе «3efg» – 2 изученных изолята. Последовательности, выделенные из организма кроликов, с вероятностью 94% образуют отдельную кладу дендрограммы в пределах 3-го генотипа. Изученные нуклеотидные последовательности ВГЕ, выделенные из организма человека и животных, кластеризуются с референсными последовательностями 3c, 3f, 3i и 3ra субгенотипов. Доказана возможность завоза ВГЕ в Республику Беларусь с территории Западной Европы и Российской Федерации, а также существование аутохтонных случаев заболевания ВГЕ, имеющих зоонозную природу.
The objective of this research was to study the genetic diversity of hepatitis E virus (HEV) strains obtained from humans and animals in Belarus. Samples of biological material from 97 patients, 79 pigs, 28 wild boars, 40 deer, 359 rabbits were tested for HEV RNA in RT-PCR. The obtained nucleotide sequences (n=9) were subjected to sequencing and phylogenetic analysis. A model of evolutionary relationships for the sequences encoding a fragment of the viral capsid protein was constructed. The sequences from this study split up between the two main clades of subgenotypes of the viral genotype 3. Within the “3abchij” clade, 5 of the 9 studied sequences were clustered, and within the “3efg” clade 2 studied isolates were the subject to clustering. The sequences from rabbits formed a separate clade on dendrogram within the genotype 3 with a probability of 94%. The studied HEV nucleotide sequences obtained from humans and animals were clustered with subgenotype reference sequences 3c, 3f, 3i, and 3ra. The possibility of HEV import to the Republic of Belarus from Western Europe and the Russian Federation, as well as existence of autochthonous zoonotic cases of HEV infection have been proved.
Revisión del género Agave en Venezuela: Variación de la diversidad
Authors: Rodríguez José Rafael , Díaz-de-Arends Miriam , Wingfield† Robert 
Published: March 2022

El objeto primordial del presente estudio fue elaborar un catálogo preliminar de las especies de Agave que confluyen como cultivadas y de manera natural que se registraron luego de la búsqueda en campo y revisión en el herbario. Se realizó la descripción y caracterización que muestran las similitudes y diferencias respecto a especies determinadas en otros países, con claves realizadas por el botánico Robert Wingfield (Wingf.), lo que permitió elaborar un catálogo florístico exhaustivo y representativo del género Agave, debido a que existen muchas identificaciones tentativas o genéricas en algunos pliegos de herbarios, en Venezuela. La investigación se realizó en bosques xerofíticos de Falcón. En la región semiárida están presentes algunas especies con distribución restringida para el caribe, descritas en tiempo reciente y en el pasado (novedades taxonómicas), y también se localizan algunas novedades corológicas. Las claves para diferenciar los ejemplares estudiados, fueron cotejadas con las descripciones de Wingfield (2018).
ANALISIS INOVASI PENINGKATAN PELAYANAN SAMSAT SEBAGAI PENUNJANG PENERIMAAN PENDAPATAN ASLI DAERAH (PAD) SERTA PENGARUHNYA TERHADAP PERTUMBUHAN EKONOMI DAERAH
Authors: Wowiling Fhilne Lisa , Rotinsulu Debby Ch. , Engka Daisy S.M. 
Published: March 2022

ABSTRAKPenelitian ini bertujuan untuk mengetahui (1) mencari inovasi pelayanan yang sesuai dengan situasi dan kondisi demi meningkatkan penerimaan PAD. (2) bagaimana perbandingan penerimaan PKB dan BBNKB, sebelum dan sesudah inovasi pelayanan Samsat dan pengaruhnya terhadap Pertumbuhan Ekonomi Provinsi Sulawesi Utara. Penelitian ini menggunakan metode deskriptif kuantitatif. Teknik pengumpulan data dari primer melalui wawancara dan data sekunder. Data yang digunakan adalah data piutang tahun 2015, data pendapatan daerah provinsi Sulawesi Utara Tahun 2016-2019, data realisasi per triwulan tahun 2016-2019. Analisis data menggunakan analisis regresi real dan regresi dummy. Hasil dari penelitian ini adalah : (1) inovasi memberikan peningkatan realisasi penerimaan yang cukup signifikan. (2) PAD mempengaruhi pertumbuhan ekonomi daerah Sulawesi Utara. Selalu memberikan inovasi pelayanan yang diinginkan masyarakat wajib pajak, sehingga tercipta kerja sama yang baik antara pemungut dan wajib pajak dalam melaksanakan tugas dan kewajiban. Kata kunci : Inovasi Samsat, Pajak Daerah, Pertumbuhan Ekonomi Daerah. ABSTRACTThis study aims to find out (1) find service innovations that are in accordance with the situation and conditions in order to increase PAD acceptance. (2) how is the comparison of PKB and BBNKB revenues, before and after the innovation of Samsat services and their effect on the Economic Growth of North Sulawesi Province.This study uses a quantitative descriptive method. Data collection techniques from primary through interviews and secondary data. The data used is 2015 receivables data, North Sulawesi provincial income data for 2016-2019, realization data for the 2016-2019 quarter. Data analysis used real regression analysis and dummy regression.The results of this study are: (1) innovation provides a significant increase in revenue realization. (2) PAD affects the regional economic growth of North Sulawesi. Always provide service innovations that are desired by the taxpayer community, so as to create good cooperation between collectors and taxpayers in carrying out their duties and obligations. Key words: Samsat Innovation, Regional Taxes, Regional Economic Growth.
EDUKASI ACTIVITY DAILY LIVING PADA PENDERITA OSTEOARTHRITIS KNEE DI KELURAHAN TALANG BANJAR
Authors: Permata Sari Indah , Hasmar Wanti , Faridah Faridah 
Published: March 2022

ABSTRACT
Osteoarthritis is a progressive degenerative joint disease in which the cartilage that protects the ends of the bones begins to break down, causing pain and loss of mobility. Osteoarthritis is one of the complaints that can be treated by physiotherapy. Physiotherapy program in education activity daily living osteoarthritis aims to improve functional abilities so that they can carry out activities as usual, reduce impairment and improve function, protect joints from further damage. Activity daily living education for knee osteoarthritis includes stretching exercises, flexibility exercises, and osteoarthritis exercises. The method of community service activities is carried out using the lecture method, and asking questions about osteoarthritis, then distributing leaflets. The results of this educational activity are very useful for people with osteoarthritis of the knee, when given this exercise, mothers or the elderly feel happy because this activity is very useful for reducing their stiffness and pain complaints. The conclusion of this educational activity is that mothers who take part in the activity already understand exercises for osteoarthritis of the knee.
Keyword: Osteoarthritis Knee, Physiotherapy, Activity Daily Living
A Dialética do Concreto: um aporte epistemológico frutífero nas pesquisas agroecológicas?
Authors: Gadelha Renata , Schütz Rosalvo 
Published: March 2022

This article addresses how dialectical historical materialism, as presented by the philosopher Karel Kosik, represents a conceptual contribution that offers an expanded the epistemological and methodological vision suited to research in agroecology. When used together, concepts such as concrete totality, work, praxis, historicity, and dialecticsadvance the potential for analysis and thematization in research on the Brazilian countryside, agroecosystems, gender relations, and rural and city relations, and also expand our understanding by recognizing the importance of social movements to advance and strengthen agroecology. Given the multidimensional nature of agroecology in theory as well as practice, the productive appropriation of Kosik's thinking certainly represents a valuable reference.elocation-id: e2230102Received: 09.30.2021 • Accepted: 01.28.2022 • Published: 02.21.2022Original article / Blind peer review / Open access
Evidence that the Hot Jupiter WASP-77 A b Formed Beyond Its Parent Protoplanetary Disk’s H2O Ice Line
Authors: Reggiani Henrique , Schlaufman Kevin C. , Healy Brian F. , Lothringer Joshua D. , Sing David K. 
Published: March 2022

Abstract
Idealized protoplanetary disk and giant planet formation models have been interpreted to suggest that a giant planet’s atmospheric abundances can be used to infer its formation location in its parent protoplanetary disk. It has recently been reported that the hot Jupiter WASP-77 A b has subsolar atmospheric carbon and oxygen abundances with a solar C/O abundance ratio. Assuming solar carbon and oxygen abundances for its host star WASP-77 A, WASP-77 A b’s atmospheric carbon and oxygen abundances possibly indicate that it accreted its envelope interior to its parent protoplanetary disk’s H2O ice line from carbon-depleted gas with little subsequent planetesimal accretion or core erosion. We show that the photospheric abundances of carbon and oxygen in WASP-77 A are supersolar with a subsolar C/O abundance ratio, implying that WASP-77 A b’s atmosphere has significantly substellar carbon and oxygen abundances with a superstellar C/O ratio. Our result possibly indicates that WASP-77 A b’s envelope was accreted by the planet beyond its parent protoplanetary disk's H2O ice line. While numerous theoretical complications to these idealized models have now been identified, the possibility of nonsolar protoplanetary disk abundance ratios confound even the most sophisticated protoplanetary disk and giant planet formation models. We therefore argue that giant planet atmospheric abundance ratios can only be meaningfully interpreted relative to the possibly nonsolar mean compositions of their parent protoplanetary disks as recorded in the photospheric abundances of their dwarf host stars.
Revisiting the Full Sets of Orbital Parameters for the XO-3 System: No Evidence for Temporal Variation of the Spin–Orbit Angle
Authors: Worku Keduse , Wang Songhu , Burt Jennifer , Rice Malena , Wang Xian-Yu , Wang Yong-Hao , Vogt Steven S. , Butler R. Paul , Addison Brett , Holden Brad , Peng Xi-Yan , Wu Zhen-Yu , Zhou Xu , Liu Hui-Gen , Zhang Hui , Zhou Ji-Lin , Laughlin Gregory 
Published: March 2022

Abstract
We present 12 new transit light curves and 16 new out-of-transit radial-velocity measurements for the XO-3 system. By modeling our newly collected measurements together with archival photometric and Doppler velocimetric data, we confirmed the unusual configuration of the XO-3 system, which contains a massive planet (

M

P

=

11.92

−
0.63

+
0.59

M

J

) on a relatively eccentric (

e
=

0.2853

−
0.0026

+
0.0027

) and short-period (3.19152 ± 0.00145 day) orbit around a massive star (

M

*

=

1.219

−
0.095

+
0.090

M

⊙

). Furthermore, we find no strong evidence for a temporal change of either

V
sin

i

*

(and by extension, the stellar spin vector of XO-3), or the transit profile (and thus orbital angular momentum vector of XO-3b). We conclude that the discrepancy in previous Rossiter–McLaughlin measurements (70.0° ± 15.0°; Hébrard et al. 2008; 37.3° ± 3.7°; Winn et al. 2009; 37.3° ± 3.0°; Hirano et al. 2011) may have stemmed from systematic noise sources.
Low-J CO Line Ratios from Single-dish CO Mapping Surveys and PHANGS-ALMA
Authors: Leroy Adam K. , Rosolowsky Erik , Usero Antonio , Sandstrom Karin , Schinnerer Eva , Schruba Andreas , Bolatto Alberto D. , Sun 孙 Jiayi 嘉懿 , Barnes Ashley. T. , Belfiore Francesco , Bigiel Frank , den Brok Jakob S. , Cao Yixian , Chiang 江 I-Da 宜達 , Chevance Mélanie , Dale Daniel A. , Eibensteiner Cosima , Faesi Christopher M. , Glover Simon C. O. , Hughes Annie , Jiménez Donaire María J. , Klessen Ralf S. , Koch Eric W. , Kruijssen J. M. Diederik , Liu Daizhong , Meidt Sharon E. , Pan Hsi-An , Pety Jérôme , Puschnig Johannes , Querejeta Miguel , Saito Toshiki , Sardone Amy , Watkins Elizabeth J. , Weiss Axel , Williams Thomas G. 
Published: March 2022

Abstract
We measure the low-J CO line ratios R
21 ≡ CO (2–1)/CO (1–0), R
32 ≡ CO (3–2)/CO (2–1), and R
31 ≡CO (3–2)/CO (1–0) using whole-disk CO maps of nearby galaxies. We draw CO (2–1) from PHANGS-ALMA, HERACLES, and follow-up IRAM surveys; CO (1–0) from COMING and the Nobeyama CO Atlas of Nearby Spiral Galaxies; and CO (3–2) from the James Clerk Maxwell Telescope Nearby Galaxy Legacy Survey and Atacama Pathfinder Experiment Large APEX Sub-Millimetre Array mapping. All together, this yields 76, 47, and 29 maps of R
21, R
32, and R
31 at 20″ ∼ 1.3 kpc resolution, covering 43, 34, and 20 galaxies. Disk galaxies with high stellar mass,

log
(

M

⋆

/

M

⊙

)
=
10.25
–
11

, and star formation rate (SFR) = 1–5 M
⊙ yr−1, dominate the sample. We find galaxy-integrated mean values and a 16%–84% range of R
21 = 0.65 (0.50–0.83), R
32 = 0.50 (0.23–0.59), and R
31 = 0.31 (0.20–0.42). We identify weak trends relating galaxy-integrated line ratios to properties expected to correlate with excitation, including SFR/M
⋆ and SFR/L
CO. Within galaxies, we measure central enhancements with respect to the galaxy-averaged value of ∼

0.18

−
0.14

+
0.09

dex for R
21,

0.27

−
0.15

+
0.13

dex for R
31, and

0.08

−
0.09

+
0.11

dex for R
32. All three line ratios anticorrelate with galactocentric radius and positively correlate with the local SFR surface density and specific SFR, and we provide approximate fits to these relations. The observed ratios can be reasonably reproduced by models with low temperature, moderate opacity, and moderate densities, in good agreement with expectations for the cold interstellar medium. Because the line ratios are expected to anticorrelate with the CO (1–0)-to-H2 conversion factor,

α

CO

1
−
0

, these results have general implications for the interpretation of CO emission from galaxies.
Interstellar Scintillation of PSR J2048−1616
Authors: Chen J. L. , Wen Z. G. , Yuan J. P. , Wang Z. , Wang N. , Yan W. M. , Yuen R. , Wang H. G. , Wang J. P. , Zhao K. , Xiang B. B. , He D. L. , Duan X. F. 
Published: March 2022

Abstract
We report on the interstellar scintillation from pulsar J2048−1616 for the first time at 732, 1369, and 3100 MHz observed with the Parkes 64 m radio telescope. Dynamic spectra are obtained and diffractive parameters are derived from two-dimensional autocorrelation analyses. The frequency dependencies of the observed diffractive scintillation timescale and decorrelation bandwidth indicate that the electron density fluctuations in the interstellar medium (ISM) do not follow the Kolmogorov spectrum. The secondary spectra are calculated by forming the Fourier power spectra of the corresponding dynamic spectra. Prominent parabolic arcs are revealed in the secondary spectra at three frequencies, which indicate that they originated from scattering by a thin screen. The scattering screen is approximately located centrally between the pulsar and Earth assuming that the ISM is stationary.