bluuebunny/crossref_metadata_2025_split huggingface dataset:
The differential influence of ambient temperature on heart rate in male and female wild pale-throated sloths (Bradypus tridactylus)
Authors: BERKEL CAGLAR , CACAN Ercan 
Published: August 2022

Abstract
Climate conditions influence cardiac health in diverse animals. Extreme heat events are now more frequent in many parts of the world due to climate change, increasing cardiovascular risks in certain wild animals. Here, we found that male and female pale-throated sloths (Bradypus tridactylus) show differential responses to ambient temperature in terms of heart rate. When we fit the data using linear models, we observed that heart rate increases with increasing ambient temperature in male sloths, while heart rate decreases with increasing temperature in female slots. We hypothesize that extreme heat conditions in the future as a result of global warming might effect the cardiovascular health of male and female sloths differently, influencing population dynamics. Our findings points that in the face of climate change, vulnerability of male and female sloths to extreme heat events in terms of cardiovascular health might significantly differ.
Waning of humoral immunity and affecting factors after BNT162b2 vaccination: a cohort study with latent growth curve model in Fukushima
Authors: Kobashi Yurie , Takebayashi Yoshitake , Yoshida Makoto , Kawamura Takeshi , Shimazu Yuzo , Kaneko Yudai , Nishikawa Yoshitaka , Nakayama Aya , Takita Morihiro , Tianchen Zhao , Yamamoto Chika , Ito Naomi , Tsubokura Masaharu 
Published: August 2022

Abstract
Measuring long-term antibody titer kinetics and subsequent COVID-19 vaccinations are crucial for identifying vulnerable populations. Our aim was to determine the association between long-term antibody kinetics up to seven months post second vaccination, including peak titers and factors. A three-time survey was performed in 2021 on healthcare workers in Japan to investigate the changes in humoral immunity using chemiluminescence immunoassay. We included participants who completed the second-dose vaccination, the antibody survey for all three terms, and those who were not infected with COVID-19. A latent growth curve model was used to identify the factors affecting the peak titer and decreasing the antibody slope. Overall, 205 eligible participants were included in the final analysis. Of these, the mean titers of immunoglobulin G (IgG) against the spike (S) protein and the neutralizing activity at seven months after the second vaccination decreased to 154.3 AU/ml (8.8% of the peak titer) and 62.1 AU/ml (9.5% of the peak titer), respectively. The growth model of IgG showed that age significantly affected peak titers (p < 0.001); however, a significant difference was not found for the decreasing slope. In conclusion, aging adults had significantly lower peak antibody titers, however age did not relate to decreasing slope.
Efficacy and safety of Nimotuzumab combined with chemoradiotherapy in the treatment of locally advanced cervical cancer
Authors: Zhang Lei , Jiang Yuqi , Jiang Peng , Chen Zhiying , Cui Huanliang , Zhang Yongchun 
Published: August 2022

Abstract
Background: Platinum-based concurrent chemoradiotherapy (CCRT) is the primary treatment for locally advanced cervical cancer (LACC). Improving the efficacy of LACC treatment is the focus of clinical research. This study aimed to investigate the efficacy and safety of nimotuzumab combined with CCRT compared with CCRT for treating LACC.Methods: Patients with LACC treated at the Affiliated Hospital of Qingdao University from March 2017 to December 2019 were collected and classified into Nimotuzumab plus chemoradiotherapy (N+CCRT) group and concurrent chemoradiotherapy (CCRT) group. Histological subtype was collected. The primary endpoints were overall survival (OS) and progression-free survival (PFS), as well as the secondary endpoints were Complete response rate (CRR), objective response rate (ORR), and adverse events (AEs).Results: A total of 120 patients (65 in the N+CCRT group and 55 in the CCRT group) were enrolled with a median follow-up time of 37 months. In N+CCRT group, 1-, 2-, and 3-year OS rates were 98.46%, 95.38% and 90.50%, 1-, 2-, and 3-year cumulative PFS rates were 89.23%, 83.08% and 79.73%, CRR was 86.15% (56/65), the ORR was 92.31% (60/65), respectively. In CCRT group, 1-, 2-, and 3-year OS rates were 94.55%, 87.27%, and 78.18%, 1-, 2-, and 3-year PFS rates were 81.82%, 69.09% and 59.69%, CRR was 70.91% (39/55), ORR was 87.27% (48/55), respectively. CRR (86.15% vs. 70.91%, P=0.040) and 3-year PFS rates (79.73% vs. 59.69%, P=0.039) were significantly higher in N+CCRT group. AEs during treatment mainly included bone marrow suppression, gastrointestinal reactions, radiation enteritis, hepatic impairment, and radiation cystitis, and there was no significant difference between the two groups (P > 0.05).Conclusion: Nimotuzumab combined with CCRT enhanced PFS and CRR for LACC patients and was well tolerated.
Peripherally Inserted Central Venous Catheter for Pediatric Hematologic Diseases; A Retrospective 11-year Single-center Experience.
Authors: Ligia Silvio , Morano Salvatore Giacomo , Kaiser Francesca , Micozzi Alessandra , Moleti Maria Luisa , Barberi Walter , Giona Fiorina , Chistolini Antonio , Arena Valentina , Piciocchi Alfonso , Forgione Maurizio , Gasperini Giulia , Fabbri Marco , Testi Anna Maria 
Published: August 2022

Abstract
Purpose. Peripherally-inserted central catheters (PICCs) are successfully increasingly used in children in onco-hematologic setting. PICC insertion, especially in oncologic patients, can be associated with adverse events (thrombosis, obstruction and infections). Data regarding the use of PICC, as long-term access in pediatric patients with severe hematologic diseases, are still limited. Methods. We retrospectively evaluated the safety and efficacy of 218 PICC, inserted in 154 pediatric patients diagnosed and treated at Pediatric Hematology Unit, Sapienza University of Rome, for severe hematologic disease in a 11-year period (98 acute lymphoblastic leukemias, 20 acute myeloid leukemias, 20 Hodgkin lymphomas, 6 non-Hodgkin lymphomas, 8 severe aplastic anemias, 2 acquired thrombotic thrombocytopenias). Results. The 218 PICC analyzed were in situ for a median dwell time of 160 days (range 12–898). In 38 children, PICC was inserted twice and in 10, three times or more due to hematopoietic stem cell transplant, disease recurrence or PICC-related complications. The overall complication rate was 32%: central-line associated bloodstream infections (CLABSI) occurred in 21% of cases after a median time of 105 days; a catheter-related thrombosis (CRT) in 3% and mechanical complications in 8% of cases. Premature removal for complications occurred in 36.7% of PICC. No death related to PICC complications was observed. Conclusion. In our experience, PICC was a cheap, safe and reliable device for long-term intravenous access in children with severe hematologic illnesses. This has been possible with the help of dedicated PICC team.
Evolutionary Game Analysis of Inter-provincial Diversified Ecological Compensation Collaborative Governance
Authors: Lu Yali , Fan Linfang , Zhai Luyu 
Published: August 2022

Abstract
Establishing a diversified ecological compensation mechanism for inter-provincial river basins is an important measure to effectively balance the relationship between water quality protection and economic development. However, in the practice of diversified ecological compensation of river basin water ecology, the conflicts of interests and contradictions between upstream and downstream governments in water resources management and protection become an important obstacle to the sustainable development of the river basin. To solve the above problems, this paper proposes the operation mode of a diversified ecological compensation mechanism based on collaborative governance among local governments, to promote the diversified ecological compensation mechanism to effectively match the demands of interest subjects and dynamically adjust the combination of compensation methods. The evolutionary game model of diversified ecological compensation cooperative governance between upstream and downstream governments is constructed, the dynamic simulation analysis is carried out by taking Shaanxi and Henan provinces as examples. The results show that the higher the initial willingness of upstream governments to diversify ecological compensation, the faster the stability of the collaborative governance system. When the fund allocation ratio of the diversified compensation method is biased to the government compensation, the stable state of the system can be achieved faster. The agreement guarantee cost has a greater impact on the upstream government, and it is easier to achieve system stability when the revenue distribution ratio is biased toward the downstream government. A good incentive and constraint mechanism can effectively promote the the system’ stability and have a more significant impact on the downstream government.
Assessment of the uncertainty of evaporation estimation models using Bayesian Model Averaging and their impact on reservoir operation
Authors: Koupai Jahangir Abedi , Soltani Mohadeseh , Abedi-koupai Jahangir , Gohari Alireza 
Published: August 2022

Abstract
Accurate estimation of evaporation losses is vital for efficient reservoir operation and optimal water allocation for various purposes. Due to multiple sources of error, uncertainty assessment is considered a fundamental step before using the outputs of models. This study aims to reduce the uncertainty in evaporation estimation models and investigate the influence of their uncertainty on the Zayandeh-Rud reservoir operation. The Bayesian Model Averaging (BMA) approach was used to merge predictions of eight evaporation models, and the Monte Carlo sampling method was conducted to derive 90% uncertainty intervals. The behavior of this system was examined using statistical performance indices such as time-based reliability, resilience, and vulnerability. The results of the study indicated that the models had different abilities in estimating evaporation and cannot fully estimate the pan evaporation data without including errors. The application of the BMA technique resulted in a reduced error rate and more accurate prediction of evaporation in all months. Moreover, applying different evaporation estimation methods affected the magnitude of the failure of the system and the speed of recovery from failure to a satisfactory state and caused an increased resilience index and a decreased vulnerability index.
Satellite and multi algorithm capability for flood hazard assessment and mapping in northern Iran
Authors: Solaimani Karim , Darvishi Shadman , Shokrian Fatemeh 
Published: August 2022

Abstract
Iran is one of the most flood prone areas in the world. The spring flood of 2019 was recorded one of the most devastating flood events in northern region of Iran. In this study, Sentinel-1, Sentinel-2, Sentinel-3 and Landsat-8 images were used to extract the flood map. Then, flood maps of these areas were prepared using Random Forest (RF) algorithm for Sentinel images and Support Vector Machine (SVM) algorithm for Landsat-8 images. In addition, flooding in these areas was assessed using the Fuzzy Best Worse Model - Weighted Multi-Criteria Analysis (FBWM-WMCA). The results of FBWM model showed that the criteria of precipitation, slope, height, land use, drainage density and distance from channel were the highest and the criteria of Curvature, Geology, Topographic Wetness Index (TWI), Stream Transport Index (STI), Stream Power Index (SPI) and The Topographic Ruggedness Index (TRI) played the lowest role in flooding in these areas. According to the FBWM-WMCA model, 38% of the Gorgan watershed in the northern, northwestern, western and southwestern parts and 45% of the Atrak watershed in the eastern, northeastern, northern and western parts are in high flood risk. The overall accuracy of the 2019 flood maps in Gorgan watershed for Sentinel-1, Sentinel-2, Sentinel-3 and Landsat-8 images is 89, 87, 80 and 85% and for Atrak is 91, 88, 82 and 86 percentages respectively. In general, based on the results of this study, FBWM and FBWM-WMCA models are effective and efficient for determining the weight of criteria and preparing flood risk maps, respectively.
Combined effects of variable electrical conductivity and microstructural/multiple slips on MHD flow of micropolar nanofluid: Food industries applications
Authors: Abou-zeid M. Y. , Ibrahim M. G. 
Published: August 2022

Abstract
Electrical conductivity has a vital role in food industries through heating operations. So, this paper focused on the temperature-dependent electrical conductivity and Joule heating effects on the boundary layer flow of micropolar fluid. Activation energy, microstructural/multiple slips, and thermal radiation effects are considered. Appropriate similarity variables convert the resulting system of partial differential equations (PDEs) to a model of highly non-linear ordinary differential equations (ODEs). Semi-analytical results are obtained using a highly accurate/trusted technique called the Shooting technique. Accuracy of obtained results is approved/confirmed semi-analytically with recently published results by Dawar 2021 using the generalized differential transform method GDTM by Mathematica 13.1.1. Results show that the temperature-dependent electrical conductivity parameter raises the fluid temperature, and more energy is gained in the heating operation system, which is significant in the design of Ohmic heaters (food industry processes).
Preliminary Study on the Relationship between VKORC1 Gene Polymorphism and Warfarin Anticoagulant Therapy in Chinese patients with Continuous-Flow Left Ventricular Assist Devices
Authors: Yu Ya-Hong , Zhu Nan , Jia Ke-Gang , Song Yu , Wang Wei 
Published: August 2022

Abstract
Purpose
This study explored the effect of VKORC1 gene polymorphism on the early application of warfarin dosage in left ventricular assist device (LVAD) implantation as well as the time in therapeutic range (TTR) within 3 months of surgery, thereby providing a basis for anticoagulation decision-making in patients with LVADs.
Methods
Retrospective analysis was used to review the warfarin-related genetic data of patients who underwent LVAD implantation in TEDA International Cardiovascular Hospital from September 2020 to August 2021. This study analyzed the effects of different genotypes on (1) the number of days to reach the target international normalized ratio (INR) (defined as 2.0–2.5); (2) the cumulative dose, average dose, and last dose before reaching the target INR; and (3) the TTR within 3 months of LVAD implantation.
Results
Out of 20 patients, 15 patients (75.0%) had VKORC1 − 1639AA and CYP2C9*1/*1 polymorphisms, and 5 patients (25.0%) had VKORC1 − 1639GA and CYP2C9*1/*1 polymorphisms. Compared with patients with LVADs carrying the VKORC1 − 1639GA genotype, those carrying the VKORC1 − 1639AA genotype took significantly fewer days to reach the target INR (5.6 vs. 14.6 days, P < 0.001), a lower cumulative warfarin dose (20.5 vs. 66.2 mg, P < 0.001), a lower average warfarin dose (3.5 vs. 4.5 mg, P = 0.030), and a lower dose of the final warfarin administered before the target INR was achieved (3.4 vs. 5.5 mg, P = 0.030). The percentage of TTR was not significantly different between the two VKORC1 genotypes on days 7–30 (50.00% for the AA genotype vs. 45.29% for the GA genotype, P = 0.26) or days 31–90 (53.03% for the AA genotype vs. 50.93% for the GA genotype, P = 0.25) after LVAD implantation.
Conclusion
Patients with the VKORC1 − 1639AA genotype reached the target INR faster than those with the GA genotype, and the total dose needed to achieve the target was smaller. Genotype-guided warfarin dosing may allow safer anticoagulation by achieving the target INR with less risk to the patient, but it did not affect long-term TTR management in this study.
MoS2 coated planar polymer optical waveguide sensor utilizing common path interferometric principle for chlorpyrifos detection
Authors: Upadhyay Abhishek , Yadav Chandan Singh , Maurya Rajiv , Sharma Gaurav , Singh T. Sonamani , Kumar Sushil , Singh Vivek 
Published: August 2022

AbstractA common path Mach-Zehnder interferometer is fabricated using planer polymer waveguide having MoS2as an adlayer for chlorpyrifos detection. The dispersion characteristic and cutoff condition of proposed waveguide is obtained theoretically and hence the cutoff film thickness is optimised to get TE0and TM0propagating modes. Variation between the phase shift of propagating modes with the concentration of pure chlorpyrifos and its real commercial sample are obtained. A good linear variation between phase shift and concentration of chlorpyriphos is obtained in our fabricated waveguide for all considered temperatures. The obtained maximum sensitivity, minimum limit of detection and limit of quantification of chlorpyrifos is 5.66 degree/µM, 1.57µM and 5.24µM respectively, at 450C. The capability of the fabricated sensor to generate distinct response for pure and real sample of chlorpyrifos at different concentration and temperature were confirmed by principal component analysis. Since the response of sensor is better for real sample at lower temperature, therefore it is recommended that the concentration of chlorpyrifos in real sample should be measure at low temperature.
Flexible patterns of information transfer in frustrated networks of phase oscillators
Authors: Khatami Saideh , Bolhasani Ehsan , Perc Matjaz , Valizadeh Alireza 
Published: August 2022

Abstract
Brain networks are characterized by flexible patterns of pairwise correlations and information exchange between different brain regions. Such dynamic patterns are crucial for an efficient response of the brain to environmental and cognitive demands. We here propose that the collective oscillations in the brain can provide a mechanism to control dynamical interactions and the exchange of information across brain networks. In particular, we show that the phase difference between oscillatory activities in different brain regions determines the transmission of neural signals. To further corroborate this, we study a network of coupled oscillators with repulsive couplings and show that the amount of information transfer between the nodes is determined by the phase differences among them. The emergence of multiple (locally) stable states due to the frustration makes it possible to change the patterns of information transfer between the nodes by means of the switching between different stable states. Our results indicate that frustration can be the mechanism through which large scale brain networks control the effective connectivity and the routes for the information transfer between different brain regions.PACS 87.19.La · 87.19.lo · 82.40.Bj
A Set-Theoretic Decision Procedure for Quantifier-Free, Decidable Languages Extended with Restricted Quantifiers
Authors: Cristiá Maximiliano , Rossi Gianfranco 
Published: August 2022

Abstract

Let LX be the language of first-order, decidable theory X. Consider the language, LRQ(X), that extends LX with formulas of the form ∀ x ∈ A : ϕ (restricted universal quantifier, RUQ) and ∃ x ∈ A : ϕ (restricted existential quantifier, REQ), where A is a finite set and ϕ is a formula made of X-formulas, RUQ and REQ. That is, LRQ(X) admits nested restricted quantifiers. In this paper we present a decision procedure for LRQ(X) based on the decision procedure already defined for the Boolean algebra of finite sets extended with restricted intensional sets (LRIS). The implementation of the decision procedure as part of the {log} (‘setlog’) tool is also introduced. The usefulness of the approach is shown through a number of examples drawn from several real-world case studies.
Community composition and differential analysis of rhizosphere soil microorganism and endophytes in Schisandra sphenanthera Rehd. et Wils.
Authors: Wang Xiao-Rui , Qin Xiao-Lu , Pu Han , Fang Xi-Lin , Gu Wei 
Published: August 2022

Abstract
Background and aims: Endophyte and rhizosphere soil microorganism are vital microbial environments of the plant, namely plant microenvironments. A robust understanding of the structural composition of the microbiome present in below-ground and above-ground communities has remained elusive. Schisandra sphenanthera Rehd. et Wils. is a kind of traditional Chinese Medicine (TCM) of Schisandra, which can protect the kidney and liver. Methods: In this study, high-throughput sequencing analysis is applied to unravel microbial communities in rhizosphere soil and different parts of wild S. sphenanthera, and the movement regularity of endophytes in plant tissues.Results: There are differences in microbial composition and diversity between rhizosphere soil and four parts of S. sphenanthera. Proteobacteria, Cyanobacteria, and Acidobacteria are main bacteria, Ascomycota and Basidiomycota are main fungi at phylum level of microbe in S. sphenanthera. There are 12 common bacterial genera and 11 common fungal genera in rhizosphere soil and different parts of S. sphenanthera. In addition, each of the four parts and rhizosphere soil have its own dominant communities, such as Achromobacter (stem and leaf) and Methylobacterium (leaf). OTUs clustering results indicate that the bacterial community of root is greatly influenced by rhizosphere soil, while the microbial community of stem and fruit are greatly affected by the microorganisms of leaf. Conclusions: Understanding the microbial community structure and diversity in rhizosphere soil and different parts of S. sphenanthera can provide basis for further study of host-microbial interactions of S. sphenanthera in phytoremediation, sustainable utilization, and secondary metabolite production.
Single-Channel Blind Source Separation using Adaptive Mode Separation- Based Wavelet Transform and Density-Based Clustering with Sparse Reconstruction
Authors: kacha abdellah , kemiha mina 
Published: August 2022

Abstract
In this study, the signal-channel blind source separation (SCBSS) problem has been addressed using a novel approach. The approach is based on combining the adaptive mode separation-based wavelet transform with adaptive mode separation (AMSWT) and the density-based clustering with sparse reconstruction. The approach is performed in Time frequency domain and in reverberant environment. First, using the Fourier transform, the amplitude spectrum of the observed mixture signal is obtained. Then, using variational scaling and wavelet functions, the AMSWT is introduced to adaptively extract spectral intrinsic components (SIC). To obtain a better time-frequency distribution, the AMSWT is applied to each mode. Thus, the SCBSS problem is transformed into a non-underdetermined. Then, for each frequency bin; the density-based clustering, reformulated to eigenvector clustering problem, is performed to estimate the mixing matrix. Finally, the sparse reconstruction is introduced to reconstruct the estimated source. The proposed approach has been evaluated using an objective measure of separation quality. According to experimental results, the proposed approach presents a powerful method to solve the SCBSS problem, and provide better separation performances than the existing methods.