bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID Stress, Socioeconomic Deprivation, and Intimate Partner Aggression During the COVID-19 Pandemic
Authors: Hammett Julia Friederike , Halmos Miklós B. , Parrott Dominic J. , Stappenbeck Cynthia A. 
Published: May 2022

Abstract
Background: Intimate partner aggression (IPA) is a prevalent public health concern that is associated with multiple negative consequences. Rates of IPA in the U.S. have increased since the onset of the Coronavirus Disease 2019 (COVID-19) pandemic, likely due to stress associated with the pandemic. Socioeconomic deprivation is associated with COVID-19 outcomes as well as IPA. However, whether socioeconomic deprivation interacts with COVID-19 stress in predicting IPA remains unclear. Methods: Using a sample of 510 individuals recruited via Qualtrics Research Services in April 2020, the present study tested whether socioeconomic deprivation moderates the association between COVID-19 stress and IPA perpetration and victimization. Participants completed a questionnaire battery that included measures of COVID-19 stressors and physical and psychological IPA perpetration and victimization. In addition, participants reported their residential zip codes, which were subsequently matched with scores on the Social Deprivation Index, a composite measure of seven demographic variables from the 5-year American Community Survey. Results: Sequential generalized linear models in Mplus Version 8.7 showed that the effects of COVID-19 stress on physical IPA perpetration and psychological IPA victimization can be best understood through its interactive effects with socioeconomic deprivation. Higher COVID-19 stress was associated with higher levels of physical IPA perpetration and psychological IPA victimization when socioeconomic deprivation was low but not when socioeconomic deprivation was high. Importantly, however, overall rates of IPA were higher among individuals with higher socioeconomic deprivation than among individuals with lower socioeconomic deprivation, regardless of the amount of COVID-19 stress they experienced. Conclusions: The present analyses implicate COVID-19 stress as a critical correlate of IPA and show that the association between this stress and physical IPA perpetration and psychological IPA victimization may be particularly salient among individuals who live in areas of lower socioeconomic deprivation. Furthermore, our results clearly pinpoint the detrimental effects of socioeconomic deprivation more broadly, showing that individuals who live in more deprived areas tend to have high levels of IPA regardless of their level of COVID-19 stress. These findings call for public health policies at the community and societal level that target not only COVID-related stress but also the impacts of socioeconomic inequality.
Identifying Shared Genetic Factors Underlying Epilepsy and Congenital Heart Disease in Europeans
Authors: Wu Yiming , Bayrak Cigdem Sevim , Dong Bosi , He Shixu , Stenson Peter D. , Cooper David N. , Chen Lei , Itan Yuval 
Published: May 2022

Abstract
Epilepsy (EP) and congenital heart disease (CHD) are two apparently unrelated diseases that nevertheless display substantial mutual comorbidity. Thus, whilst congenital heart defects are associated with an elevated risk of developing epilepsy, the incidence of epilepsy in CHD patients correlates with CHD severity. Although genetic determinants have been postulated to underlie the comorbidity of EP and CHD, the precise genetic etiology is unknown. We performed variant and gene association analyses on EP and CHD patients separately, using whole exomes of genetically identified Europeans from the UK Biobank and Mount Sinai BioMe Biobank. We prioritized biologically plausible candidate genes and investigated the enriched pathways and other identified comorbidities by biological proximity calculation, pathway analyses, and gene-level phenome-wide association studies. Our variant- and gene-level results point to the Voltage-Gated Calcium Channels (VGCC) pathway being a unifying framework for EP and CHD comorbidity. Additionally, pathway-level analyses indicated that the functions of disease-associated genes partially overlap between the two disease entities. Lastly, phenome-wide association analyses of prioritized candidate genes revealed that cerebral blood flow and ulcerative colitis constitute the two main traits associated with both EP and CHD.
Impacts of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of apixaban in patients with non-valvular atrial fibrillation.
Authors: Nakagawa Junichi , Kinjo Takahiko , Aiuchi Naoya , Ueno Kayo , Tomita Hirofumi , Niioka Takenori 
Published: May 2022

Abstract
Purpose: We examined the impact of polymorphisms in genes encoding cytochrome P450 (CYP) 3A5 (gene code CYP3A5), P-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2), cytochrome P450 oxidoreductase (POR) and pregnane X receptor (PXR; NR1I2) on the steady-state trough concentrations (C0h) of apixaban. Methods: The analyses included 86 patients with non-valvular atrial fibrillation (NVAF) undergoing AF catheter ablation. The CYP3A5*3; ABCG2 421C>A; ABCB1 1236C>T, 2677G>A/T, 3435C>T, and 2482-2236G>A; NR1I2 11156A>C, 11193T>C, and 8055C>T; and POR*28 genotypes were determined. The combination of the noted NR1I2 genotypes determined the PXR*1B haplotype. Results: Stepwise selection multiple linear regression analyses demonstrated that decreased creatinine clearance and the PXR*1B/*1B genotype correlated with increased apixaban C0h, while the presence of the POR*28 allele correlated with decreased C0h (partial R2 = 0.196, 0.057, and 0.046, all P < 0.05). The C0h of apixaban showed a moderate correlation with prothrombin time (r = 0.594 P < 0.001). Conclusion: The PXR*1B haplotype and POR*28 genotype statuses, which involve genes that impact the expression of multiple drug-metabolizing enzymes and drug-transporters, may affect the C0h of apixaban.
WITHDRAWN: The role of maintaining the integrity of sexual response cycle in the improvements of ovulation rate and pregnancy outcomes
Authors: Tang Jiexin , Lu Danhua , Jiang Caixia , Wang Zhilin , Xie Yucen , Zhang Dan 
Published: May 2022

Abstract
Background
Previous studies reported that the timing and frequency of intercourse were associated with the menstrual cycle and immune response, with fewer research on the correlation between sexual response cycle and ovulation rate or pregnancy outcomes.
Methods
We performed a prospective cohort study of 150 patients undergoing ultrasonic ovulation monitoring, with guidance on sexual behavior, psychological counseling, alkalizate on of the vaginal environment conducted for the experimental group(n = 75).
Outcomes:
The overall score of FSFI questionnaire, the score of sexual satisfaction degree, the incidence of orgasm in coitus, the pre-pregnancy cycle of ovulation monitoring, periodic ovulation rate, clinical pregnancy rate, biochemical pregnancy rate, live birth rate and abortion rate of the two groups were analyzed.
Results
After intervention, the incidence of FSD in the experimental group was decreased, with an improvement in sexual satisfaction degree and a higher incidence of orgasm. The periodic ovulation rate, clinical pregnancy rate and live birth rate in the experimental group were significantly higher, with shorter average pre-pregnancy cycle of ovulation monitoring. Furthermore, there were no differences in biochemical pregnancy rate and abortion rate.
Conclusion
Taken together, guidance on sexual behavior not only enhance the relationship between couples and alleviate sexual dysfunction, but also have crucial reproductive significance.
Tight Adherent Feature on Optical Coherence Tomography Predict Postoperative Visual Outcome in Epiretinal Membrane Eyes
Authors: Lai Tzu-Ting , Wu Li-Li , Hsieh Yi-Ting , Lee Chia-Chen , Peng Yi-Jie 
Published: May 2022

Abstract
Background: To identify the predictive parameter among preoperative measurements that best predicts postoperative visual outcome in the epiretinal membrane (ERM). Methods: Thirty-three consecutive patients with idiopathic unilateral ERM patients between 2015 and 2018 were enrolled. Nineteen healthy normal eyes were selected as an independent age-matched group. Based on preoperative optical coherence tomography (OCT), we further divided the patients with ERM into two groups: type 1, loosely attached ERM, and type 2, tight adherent ERM. We documented the vision and thickness of various retinal layers: nerve fiber layer, ganglion cell layer, inner plexiform layer (GCL+IPL), inner nuclear layer (INL), outer retinal layer (ORL), and retinal pigment epithelium/Bruch complex layer before and after the surgery. The association between postoperative visual acuity and these variables was analyzed using multiple linear regression analysis. Results: All retinal layers of ERM eyes were thicker than the normal eyes (P < 0.05). Among ERMs, we identified 11 eyes with type 1 adhesions and 22 eyes with type 2 adhesions. The preoperative GCL + IPL layers were significantly thicker in type 2 patients than in type 1 patients (93.67±33.03 um vs 167.71±13.77 um; p=0.023). Greater GCL+IPL thickness was correlated with a worse postoperative visual acuity and multiple linear regression analysis showed that GCL+IPL thickness was an independent predictor of postoperative visual acuity (VA) (beta value=0.689; p=0.012). A greater thickness of GCL+IPL layers of type 2 patients had worse postoperative best-corrected visual acuity (BCVA) (p=0.028). Ectopic inner foveal layers with disappearance of fovea pit were persistently presented in OCT profiles of both groups. Conclusion: Idiopathic ERM demonstrated significantly thicker inner retinal layers (GCL + IPL and INL). However, the ORL thickness was similar between the normal eyes and ERM eyes. The preoperative GCL + IPL layers were significantly thicker in patients with type 2 ERM than that in patients with type 1 ERM. The increase in GCL+IPL thickness was significantly correlated with worse postoperative visual outcomes.
Docking, Molecular Dynamic Simulation and ADMET Analysis of Novel Honokiol Derivatives against Breast Cancer Target Protein LKB1
Authors: Shahid Izzah , Raza Rabail Zehra , Akbar Ansa , Abbasi Sumra Wajid , Mehnaz Samina 
Published: May 2022

Abstract
Breast cancer is characterized by an uncontrolled cell growth in the breast tissue and is a leading cause of death globally. Cytotoxic effects and reduced efficacy of currently used therapeutics insist to look for new chemo-preventive strategies against breast cancer. LKB1 gene has recently been categorized as a tumor suppressor gene where it’s inactivation can cause sporadic carcinomas in various tissues, including the breast. Mutations in the highly conserved LKB1 catalytic domain leads to the loss of function and subsequently elevated expression of pluripotency factors in breast cancer. The utilization of drug-likeness filters and molecular simulation has helped evaluate the pharmacological activity and binding abilities of selected drug candidates against the target proteins in many cancer studies. The current in silico study provides a pharmacoinformatic approach to decipher the potential of novel honokiol derivatives as therapeutic agents against breast cancer through binding of target LKB1 protein. Among the three honokiol derivatives, ligand-protein binding energy of 3' formylhonokiol with LKB1 protein was found to be the highest via molecular docking. Moreover, stability and compactness inferred for 3' formylhonokiol with LKB1 is suggestive of 3' formylhonokiol being an effective activator of LKB1 via simulation studies. It was further established that 3' formylhonokiol displays an excellent profile of distribution, metabolism, and absorption, indicating it as an anticipated future drug candidate.
Implementation of a regional standardised model for perinatal electronic medical records
Authors: Leante-Castellanos José Luis , Mañas-Uxó María Isabel , Garnica-Martínez Beatriz , Tomás-Lizcano Aurora , Muñoz-Soto Andrés 
Published: May 2022

Abstract
Background: Electronic recording of newborn health information contributes to improving the quality of care. Nonetheless, there is limited evidence on the implementation of perinatal electronic medical records models. We describe the development and implementation of an electronic recording model that includes data on the health care provided to both the mother and the newborn, standardised for six hospitals of a regional health care system.Methods:The implementation process was developed in 2 stages. During stage 1, the tool was introduced in hospitals to stablish first contact with the healthcare staff. The second stage consisted in designing a new strategy to stabilise the model. Technical issues were fixed, and a new version was drawn up based on multidisciplinary agreement. Indicators to monitor implementation were measured in both stages and compared using the chi-squared test. Results:During stage 1, nearly every newborn got its electronic medical record with an appropriate connection to the mother’s data. However, certain forms that were meant to be filled in by staff were frequently neglected (completion rates: 36.7%-55.3%). In stage 2, there was a statistically significant increase in the completion rates of all these forms. As a result, a standardised discharge report was provided to every newborn at the end of stage 2. Conclusions: Implementation of perinatal electronic medical records that link maternal and neonatal data is complicated and experience in this area is limited. Here we describe the implementation process of a model that was reliable and standardised for an entire regional health care system.
Detoxification enzymes: comparative analysis across hemipteran species
Authors: Volonté Mariano , Traverso Lucila , Estivalis Jose Manuel Latorre , Almeida Francisca Cunha , Ons Sheila 
Published: May 2022

Abstract
Background:
Hemiptera is one of the most speciose Orders of insects, and the most speciose considering hemimetabolous. Through their evolutive history, hemipterans with different feeding habits have adapted to deal with different chemical challenges. Three major gene families are involved in xenobiotic detoxification in insects: the cytochromes P450 (CYPs), carboxyl/cholinesterases (CCEs), and glutathione transferases (GSTs). Here we perform a comparative analysis on the complement of these gene superfamilies across five hemipteran species; four heteropterans (the plant feeders pentatomids Nezara viridula and Halyomorpha halys; the hematophagous Cimex lectularius, Cimicidae, and Rhodnius prolixus, Reduviidae), and one plant feeder Auchenorryncha (Nilaparvata lugens).
Results:
Our results point to an expansion of several enzyme families associated to xenobiotic detoxification in heteropterans respect to other species, and present a dynamic evolution pattern including CYP3 clan, hormone and pheromone processing class in the CCE superfamily and Sigma class in GST superfamily. Other detoxification-related families are reduced in the Hemiptera species analyzed here: reduction or even absence of class Epsilon and reduced class Delta in GST superfamily; absence of mitochondrial family CYP12; absence of CYP9 family in CYP3 clan; and reduction or even absence of some dietary/detoxification groups of CCEs. Interestingly, the most polyphagous species analyzed here (H. halys), is also the one that presents the larger repertoire of detoxification enzymes. Gene-cluster analysis suggests that this could be due to gene duplication events.
Conclusions:
The evolutionary analysis performed here reveals characteristics that are both common and particular for heteropterans. The composition and organization of detox-related gene families could shed light on evolutionary forces that shaped their divergence. These families are both important for the detoxification of diet products and to confer tolerance or resistance to synthetic insecticides. Furthermore, we present here the first comprehensive analysis of detoxificant gene superfamilies in N. viridula, an understudied species in spite of its economic relevance as a crop pest. The information obtained is of interest for basic insect science, as much as for the control of harmful species and the management of insecticide resistance.
Tinetti balance performance is associated with mortality in older adults with Parkinson’s disease: a longitudinal study
Authors: Laurent Louise , Koskas Pierre , Estrada Janina , Sebbagh Mélanie , Lacaille Sophie , Raynaud-Simon Agathe , Lilamand Matthieu 
Published: May 2022

Abstract
Background: Parkinson’s disease (PD) is associated with a 3-fold increased risk of death and this mortality risk is closely related to advancing age. Evidence is lacking regarding the factors associated with the risks of mortality or nursing-home (NH) admission, in elderly patients with PD. We aimed at identifying the clinical characteristics associated with these outcomes, in older community dwelling patients with PD.Methods: Retrospective, observational analysis of data from patients referred to our geriatric day hospital. Motor assessment included Unified Parkinson Disease Rating Scale (UPDRS) score and UPDRS axial sub-score, Tinetti Performance Oriented Mobility Assessment (POMA) balance and gait tests, and gait speed. Levodopa equivalent dose, comorbidity, cognitive performance, functional status (basic and instrumental Activities of Daily Living) were examined. Cox proportional hazards models were performed to identify the factors associated with 5-year mortality and NH admission rate. Results: We included 98 patients (mean age 79.4±5.3) of whom 18 (18.3%) died and 19 (19.4%) were admitted into NH over the 5-year follow-up. In multivariate Cox models, poor balance on the Tinetti POMA scale (HR=0,82 95%CI (0.66-0.96), p=0.02) and older age (HR= 1,12 95%CI (1.01-1.25), p=0,04) were the only variables significantly associated with increased mortality risk. A Tinetti balance score below 11/16 was associated with a 6.7 hazard for 5-year mortality (p<0.01). No specific factor was associated with NH admissions.Conclusions: The Tinetti POMA test may be an accurate instrument for identifying the older individuals with PD at higher risk of mortality, and should be considered in clinical setting.
Da Vinci Xi: a better platform for robotic-assisted radical prostatectomy?
Authors: Chen Yi-Hsuan , Chen Marcelo , Lin Wun-Rong , Chiu Allen W. , Chen Li-Chen 
Published: May 2022

Abstract
BackgroundAn upgraded surgical robot platform, da Vinci Xi, had demonstrated multiple advantages over the previous da Vinci Si system. Better surgical outcomes had been reported in various operations except for robotic-assisted radical prostatectomy (RARP). We sought to compare and analyze the outcomes of RARP between using the da Vinci Xi and the da Vinci Si. The learning curve of docking with the new surgical robot and method for RARP was also evaluated.MethodsAn initial series of 77 RARPs have since been performed with the side docking technique since the installation of the da Vinci Xi. Another series of 96 consecutive RARPs were performed immediately before the uptake using the da Vinci Si and central docking technique. We compared the clinicopathological, perioperative, and postoperative outcomes of these two groups. We also analyzed the learning curve of the transition from central docking with the da Vinci Si to side docking with the da Vinci Xi.ResultsThe Xi group had a shorter console time (208.2 vs. 285.7 min, p=0.004), less estimated blood loss (193.5 vs. 259.9 mL, p=0.018), and faster docking time (5.12 vs. 7.95 min, p=0.002) than the Si group. There were no significant differences regarding perioperative and postoperative outcomes. The plateau of the learning curve of side docking with the da Vinci Xi system was reached after 27 cases, and led to a significantly shorter docking time than before completing the learning curve (3.72 vs. 7.70 min, p<0.001).ConclusionPerforming RARP with the da Vinci Xi system and side docking improved intraoperative outcomes and the docking time was almost negligible after gaining sufficient experience with the new system and docking technique. However, the complication rate and postoperative outcomes did not significantly benefit from the da Vinci Xi model.
Association between weight loss and outcomes in patients undergoing atrial fibrillation ablation: A systematic review and dose-response meta
Authors: Zhao Huilei , Li Xiaozhong , Yu Peng , Liu Menglu , Ma Jianyong , Wang Jinfeng , Zhu Wengen , liu xiao 
Published: May 2022

Abstract
Objectives: This study aims to determine the relationship between weight loss and outcomes in patients with atrial fibrillation (AF) ablation, as well as the potential dose-response relationship.Background: Obesity is an independent risk factor for AF, and obesity can affect the prognosis of AF. However, the role of weight loss on outcomes after ablation remains unclear.Methods: The Cochrane Library, PubMed, and Embase databases were searched to identify studies that reported a relationship between weight loss and ablation up to August 17, 2021. Relative risks (RRs) were pooled using random-effects models.Results: One randomized, open-labeled clinical trial and seven cohort studies involving 1150 patients were included. The mean body mass index of all included studies was over 30 kg/m2. The clinical trial showed nonsignificant benefit of weight loss intervention on AF recurrence (odd risk=1.02, 95% confidence interval [CI]: 0.70-1.47). Meta-analysis based on observational studies showed that the recurrence rate of AF after ablation was significantly reduced (RR=0.43, 95% CI: 0.22-0.81, I2 =97%) in relatively obesity patients with weight loss compared with the control group (morbidly obese patients without weight change). Each 10% reduction in weight was associated with a decreased risk of AF recurrence after ablation (RR=0.54, 95% CI: 0.33-0.88) with high statistical heterogeneity (I2 =76%). An inverse linear association (Pnon-linearity =0.27) between AF relapse and increasing weight loss was found.Conclusions: Our results first suggest an inverse dose-response association between weight loss in risk of recurrent AF after ablation in obese patients.