bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple‐region,N‐mixture community model to assess associations of riparian area, fragmentation, and species richness
Authors: Fogarty Frank A. , Yen Jian D. L. , Fleishman Erica , Sollmann Rahel , Ke Alison 
Published: June 2022

AbstractThe associations of habitat area and fragmentation with species richness long have been major topics within community ecology. Recent discussion has focused on properly assessing fragmentation independent of habitat area (fragmentation per se), and on whether fragmentation has significant negative or positive associations with species richness. We created a novel, multiple‐region, N‐mixture community model (MNCM) to examine the relations of riparian area and fragmentation with species richness of breeding birds in mountain ranges within the Great Basin, Nevada, USA. Our MNCM accounts for imperfect detection in count data at the survey‐point level while allowing comparisons of species richness among regions in which those points are embedded. We used individual canyons within mountain ranges as regions in our model and measured riparian area and the Normalized Landscape Shape Index, a metric of fragmentation that is independent of total riparian area. We found that riparian area, but not its fragmentation, was a primary predictor of canyon‐level species richness of both riparian obligates and all species. The relationship between riparian area and riparian obligate species richness was nonlinear: canyons with ≥25 ha woody riparian vegetation had relatively high species richness, whereas species richness was considerably lower in canyons with <25 ha. Our MNCM can be used to calculate other metrics of diversity that require abundance estimates. For example, Simpson's evenness of riparian obligate species had a weak negative association with riparian area and was not associated with fragmentation. Projections of future riparian contraction suggested that decreases in species richness are likely to be greatest in canyons that currently have moderate (~10–25 ha) amounts of riparian vegetation. Our results suggest that if a goal of management is to maximize the species richness of breeding birds in montane riparian areas in the Great Basin, it may be more effective to focus on total habitat area than on fragmentation of patches within canyons, and that canyons with at least moderate amounts of riparian vegetation should be prioritized.
Histopathological and epigenetic changes in myocardium associated with cancer therapy‐related cardiac dysfunction
Authors: Terada Chiyoko‐Ikeda , Onoue Kenji , Fujii Tomomi , Itami Hiroe , Morita Kohei , Uchiyama Tomoko , Takeda Maiko , Nakagawa Hitoshi , Nakano Tomoya , Baba Youichirou , Amemiya Kisaki , Saito Yoshihiko , Hatakeyama Kinta , Ohbayashi Chiho 
Published: June 2022

AbstractAimsCancer therapy‐related cardiac dysfunction (CTRCD) is commonly reported, but its histopathology, mechanisms, and risk factors are not known. We aimed to clarify the histopathology and mechanisms of CTRCD to identify risk factors.Methods and resultsWe performed myocardial histopathological studies on 13 endomyocardial biopsies from CTRCD patients, 35 autopsied cancer cases with or without cardiac dysfunction, and controls without cancer (10 biopsies and 9 autopsies). Cardiotoxicity risk scores were calculated based on medication; and patient‐related risk factors, fibrosis, and cardiomyocyte changes were scored; and p53 and H3K27ac histone modification were evaluated by histological score (H‐score). In the biopsy cases, all histopathological changes and the p53 evaluation were significantly higher in the CTRCD group than in the controls [p53 H‐score; 63 (9.109) vs. 33 (5.099), P < 0.05]. In patients with a short time between drug and disease onset (<4.2 years), fibrosis and p53 positively correlated (r = 0.76, P < 0.05), and in those with late onset disease (>4.2 years), cellular abnormalities and p53 trended to a positive correlation and cardiotoxicity risk scores and p53 positively correlated (r = 0.95, P < 0.05). A year after biopsy, the short‐term group had significant recovery of ejection fraction compared with the long‐term group (P < 0.05). The CTRCD group had a significantly worse overall survival prognosis than the control group [hazard ratio 7.61 (95% confidence interval 1.30–44.6), P < 0.05]. Autopsy cases with cancer treatment also had a high grade of histopathological changes, with even more severe changes in patients with cardiac dysfunction, and had increased p53 and H3K27ac expression levels, compared with controls. H‐scores of p53 and H3K27ac showed a positive correlation in the CTRCD group in biopsy cases (r = 0.62, P < 0.05) and a positive correlation in autopsy cases.ConclusionsOur results indicate distinct morphological characteristics in myocardial histopathology associated with CTRCD. p53 and H3K27ac histone modification could be sensitive markers of CTRCD and suggest a mechanistic involvement of epigenetic changes.
D‐dimer and outcomes in hospitalized heart failure patients across the ejection fraction phenotypes
Authors: Huang Liyan , Liang Lin , Tian Pengchao , Zhao Lang , Chen Yuyi , Huang Yan , Zhou Qiong , Zhai Mei , Zhang Yuhui , Ambrosio Giuseppe , Zhang Jian 
Published: June 2022

AbstractAimsThe prognostic significance of D‐dimer in hospitalized heart failure (HF) patients is incompletely characterized. We aimed to assess the association of D‐dimer levels on admission with adverse events at follow‐up in patients hospitalized with HF across all ejection fraction (EF) phenotypes.Methods and resultsConsecutive patients hospitalized from December 2006 to December 2017 for HF with D‐dimer and EF values available (n = 1795) were enrolled. Associations between D‐dimer and all‐cause death were examined at 1‐year follow‐up. Median age was 57 years, 73.4% were male, and the majority (72.1%) were in New York Heart Association Classes III–IV. EF was reduced in 53.3% (HFrEF), mildly reduced in 16.3% (HFmrEF), and preserved in 30.4% (HFpEF). Median (interquartile range) D‐dimer on admission was 0.56 (0.27–1.295) μg/mL FEU (fibrinogen‐equivalent unit) in the whole cohort, 0.64 (0.28–1.48) μg/mL FEU in HFrEF, 0.50 (0.27–1.03) μg/mL FEU in HFmrEF, and 0.495 (0.25–1.10) μg/mL FEU in HFpEF (P = 0.001). At 1‐year follow‐up, higher D‐dimer (D‐dimer ≥0.56 μg/mL FEU) independently predicted all‐cause death in total cohort [hazard ratio (HR) 1.55; 95% confidence interval (CI), 1.15–2.1], in HFrEF (HR, 1.49; P = 0.039), and in HFpEF (HR, 2.06; P = 0.033). However, no relationship was found for HFrEF or HFmrEF when D‐dimer was treated as quartiles. In sensitivity analysis, quantitatively similar but more pronounced association between D‐dimer and all‐cause death was observed in total cohort and HFpEF cohort.ConclusionsIn hospitalized HF patients, higher D‐dimer concentration was a significant and independent predictor of 1‐year all‐cause mortality. Across all HF phenotypes, this effect was most evident in HFpEF patients.
Clinical implications of left atrial changes after optimization of medical therapy in patients with heart failure
Authors: Inciardi Riccardo M. , Pagnesi Matteo , Lombardi Carlo M. , Anker Stefan D. , Cleland John G. , Dickstein Kenneth , Filippatos Gerasimos S. , Lang Chim C. , Ng Leong L. , Pellicori Pierpaolo , Ponikowski Piotr , Samani Nilesh J. , Zannad Faiez , van Veldhuisen Dirk J. , Solomon Scott D. , Voors Adriaan A. , Metra Marco 
Published: June 2022

AbstractAimsLimited data exist regarding the prognostic relevance of changes in left atrial (LA) dimensions in patients with heart failure (HF). We assessed changes in LA dimension and their relation with outcomes after optimization of guideline‐directed medical therapy (GDMT) in patients with new‐onset or worsening HF.Methods and resultsLeft atrial diameter was assessed at baseline and 9 months after GDMT optimization in 632 patients (mean age 65.8 ± 12.1 years, 22.3% female) enrolled in BIOSTAT‐CHF. LA adverse remodelling (LAAR) was defined as an increase in LA diameter on transthoracic echocardiography between baseline and 9 months. After the 9‐month visit, patients were followed for a median of 13 further months. LAAR was observed in 247 patients (39%). Larger baseline LA diameter (odds ratio [OR] 0.90; 95% confidence interval [CI] 0.87–0.93; p < 0.001) and up‐titration to higher doses of angiotensin‐converting enzyme inhibitors or angiotensin receptor blockers (ACEi/ARBs) (OR 0.56; 95% CI 0.34–0.92; p = 0.022) were independently associated with lower likelihood of LAAR. LAAR was associated with an increased risk of the composite of all‐cause mortality or HF hospitalization (log‐rank p = 0.007 and adjusted hazard ratio 1.73, 95% CI 1.22–2.45, p = 0.002). The association was more pronounced in patients without a history of atrial fibrillation (p for interaction = 0.009).ConclusionAmong patients enrolled in BIOSTAT‐CHF, LAAR was associated with an unfavourable outcome and was prevented by ACEi/ARB up‐titration. Changes in LA dimension may be a useful marker of response to treatment and improve risk stratification in patients with HF.
Hybridization of Palladium Nanoparticles with Aromatic‐Rich SU‐101 Metal‐Organic Framework for Effective Transfer Hydrogenation
Authors: Krishnaveni Valle , Esclance DMello Marilyn , Basavaiah Keloth , Samsonu Dasi , Rambhia Dheer A. , Kalidindi Suresh Babu 
Published: June 2022

AbstractMetal‐organic frameworks (MOFs) are crystalline porous materials with designable pores. In this study, we loaded Pd nanoparticles onto π‐electron rich pores of ellagic acid based SU‐101 MOF (Bi2O(H2O)2(C14H2O8) ⋅ nH2O) in order to surround Pd active sites with π‐electron rich environment. The material has been explored for the transformation of 4‐Nitro phenol (4‐NP) to 4‐Amino phenol (4‐AP) using ammonia borane (AB). AB acted as efficient transfer hydrogenation agent compared to NaBH4 because of its ability to transfer hydrogens at milder conditions. AB is safer and easy to handle compared to molecular hydrogen or NaBH4. The Pd NPs are loaded on to SU‐101 using two methodologies. One by supporting preformed Pd NPs onto MOF surface (Pd‐WCGA/SU‐101) and the other by wet impregnation method (Pd/SU‐101). The later method yields a material with strong interaction between Pd and SU‐101. The Pd/SU‐101 exhibited superior activity for 4‐NP reduction (turn over frequency=2421 h−1) using AB due to an enrichment of 4‐NP around Pd active sites by π‐electron rich pore environment.
Diphenylprolinol Silyl Ether Catalyzed Asymmetric Formal Carbo [3+3] Cycloaddition Reaction of Isopropylidenemalononitrile and α,β‐Unsaturated Aldehyde
Authors: Umekubo Nariyoshi , Han Xiaolei , Mori Naoki , Hayashi Yujiro 
Published: June 2022

AbstractEnantioselective formal carbo [3+3] cycloaddition reaction of isopropylidenemalononitrile (1) and α,β‐unsaturated aldehyde, catalyzed by diphenylprolinol silyl ether, was developed. The reaction is a domino Michael/aldol‐type reaction, followed by Al2O3‐mediated dehydration to afford 5‐substituted cyclohexene derivatives possessing a methylene‐malononitrile moiety, with excellent enantioselectivity.
Potential Application of Carbon‐based Electrical Sensor for the Highly Sensitive Diltiazem HCl Quantification in its Pharmaceutical Products and Biological Samples
Authors: Mohamed Marwa El Badry , Heakal Fakiha El‐Taib 
Published: June 2022

AbstractDiltiazem (DTZ) hydrochloride, a calcium channel blocker compound, is a very well‐known drug used by many clinicians to treat important diseases playing a role in increased morbidity and mortality among adults worldwide, namely hypertension, cardiac arrhythmia, and ischemic heart disease (angina pectoris). These diseases are a common public health concern, implying that the construction of a specific, accurate, and simple sensor for DTZ determination is needed. Herein, an innovative, portable, and sensitive modified carbon paste electrode (MCPE) was seamlessly developed based on the affordable green compound N‐bromosuccinimide (NBS) as a sensing material and tricresyl phosphate as a solvent mediator for the voltammetric determination of DTZ. The proposed NBS‐MCPE exhibited an excellent electrocatalytic activity towards the oxidation of DTZ molecules in a phosphate buffer solution of pH 5.0 in presence of 20 μM sodium dodecyl sulfate to improve the developed sensor performance. The sensor was found to respond linearly to the DTZ drug over a wide concentration ranging from 1 μM to 300 μM with a low limit of detection. LSV and EIS measurements were also used to scrutinize our sensor, in addition to using scanning electron microscopy and energy dispersive X‐ray analysis techniques for its surface morphology inspection before and after soaking in the drug‐containing solution. The applicability of the proposed sensor for the rapid, sensitive, and selective determination of DTZ in pharmaceutical preparation and human urine samples was assessed and the obtained results were compared with that of the reported HPLC analytical method.
Blue hydrogen must be done properly
Authors: Pettersen Jostein , Steeneveldt Rosetta , Grainger David , Scott Tyler , Holst Louise‐Marie , Hamborg Espen Steinseth 
Published: June 2022

AbstractFuture energy scenarios include both green and blue hydrogen, as both are needed to scale up decarbonized energy supply. A transition to renewable energy is predicted over time, but the urgency we are facing cannot be met by renewable energy alone. For blue hydrogen production, the overall greenhouse gas (GHG) emissions are primarily affected by emissions from natural gas production, processing, and transport (CO2 and methane), as well as process efficiency and carbon capture ratio. Few complete and updated analyses are available that cover the entire blue hydrogen value chain with the best available technology for process facilities, as well as the proper design, operation, and maintenance of all relevant systems and infrastructure. This paper analyses the GHG intensity of blue hydrogen, using recent data as well as input from technology providers on state‐of‐the‐art gas reforming technologies. Data are primarily based on natural gas production and transport in the North Sea Basin, with gas export from the Norwegian continental shelf to continental Europe or the United Kingdom, and with blue hydrogen production either in Norway or near pipeline landfall in the European Union or United Kingdom. Some data related to potential blue hydrogen production in the US Appalachian region are also given. The data show that the properly designed and operated value chains for blue hydrogen supply, with minimal emissions from natural gas supply and high carbon capture in hydrogen production, will give a major reduction in GHG emissions from energy end‐use. GHG footprint for end‐users based on blue hydrogen will typically be 80%–90% lower than for direct supply and use of natural gas.
Contextualizing social networks: The role of person–organization fit in the network–job performance relationship
Authors: Soltis Scott M. , Dineen Brian R. , Wolfson Mikhail A. 
Published: June 2022

AbstractWhile scholars have attended to the performance implications of employee embeddedness in social networks within the workplace, less research accounts for the interface of employee and organizational values in enabling employees to leverage these networks. Network perspectives on employee performance acknowledge that certain informal network positions create resources that are beneficial for performance while simultaneously creating demands that may diminish or erode these benefits. Leveraging a Job Demands‐Resources (JD‐R) perspective, we suggest that person–organization (PO) fit—the perceived congruence between individual and organizational values—will play a crucial role in shaping the performance effects of demands and resources inherently generated by workplace relationships. Results suggest that PO fit moderates relationships between network positions and individual job performance. Specifically, we find that having many friendships or being heavily sought out for advice enhances performance for those with higher levels of PO fit. Supplemental analyses highlight that incoming friendships or advice ties that are cross‐functional are still beneficial for those among the highest in PO fit, but also that these same network positions can be detrimental for employees who are among the lowest in PO fit. These results contribute to a more nuanced understanding of the demands and resources generated by informal networks and how the translation of these features into performance is contingent upon the extent to which an employee identifies with organizational values.
Role of electromagnetic analysis in radiative immiscible Newtonian and non‐Newtonian fluids through a microchannel with chemical reactions
Authors: Gajbhiye Sneha , Warke Arundhati , Katta Ramesh 
Published: June 2022

AbstractThe study of an immiscible fluid plays a significant role in the field of petroleum extraction, blood flow in arteries, hydrology, manufacturing process, and reservoir mechanics. These phenomena include immiscible fluids of different densities and viscosities in the same channel. Due to the various practical applications, in the current study, the generalized Couette flow of two immiscible fluids (Newtonian and non‐Newtonian fluids) of different viscosities between two infinite parallel plates under the presence of constant pressure gradient and electroosmosis is addressed. The effects such as electromagnetohydrodynamics, zeta potential, Joule heating, thermal radiation, modified Darcy's law, and chemical reaction have been also considered into account. The dimensional system of equations has been nondenationalized with suitable dimensionless quantities. The resulting nondimensional system of coupled flow equations has been solved analytically. The solutions for the velocity, temperature, and concentration have been presented. The effect of various pertinent fluid flow parameters has been displayed graphically. The current study concludes that both the velocity and temperature profiles decrease with the increase in Hartmann number and radiation parameter, whereas an increase in chemical reaction parameter uplifts the concentration of both fluids.
Integrative monitoring strategy for marine and freshwater harmful algal blooms and toxins across the freshwater-to-marine continuum
Authors: Howard Meredith D. A. , Smith Jayme , Caron David A. , Kudela Raphael M. , Loftin Keith , Hayashi Kendra , Fadness Rich , Fricke Susan , Kann Jacob , Roethler Miranda , Tatters Avery , Theroux Susanna 
Published: June 2022

Abstract
Many coastal states throughout the USA have observed negative effects in marine and estuarine environments caused by cyanotoxins produced in inland waterbodies that were transported downstream or produced in the estuaries. Estuaries and other downstream receiving waters now face the dual risk of impacts from harmful algal blooms (HABs) that occur in the coastal ocean as well as those originating in inland watersheds. Despite this risk, most HAB monitoring efforts do not account for hydrological connections in their monitoring strategies and designs. Monitoring efforts in California have revealed the persistent detection of cyanotoxins across the freshwater-to-marine continuum. These studies underscore the importance of inland waters as conduits for the transfer of cyanotoxins to the marine environment and highlight the importance of approaches that can monitor across hydrologically connected waterbodies. A HAB monitoring strategy is presented for the freshwater-to-marine continuum to inform HAB management and mitigation efforts and address the physical and hydrologic challenges encountered when monitoring in these systems. Three main recommendations are presented based on published studies, new datasets, and existing monitoring programs. First, HAB monitoring would benefit from coordinated and cohesive efforts across hydrologically interconnected waterbodies and across organizational and political boundaries and jurisdictions. Second, a combination of sampling modalities would provide the most effective monitoring for HAB toxin dynamics and transport across hydrologically connected waterbodies, from headwater sources to downstream receiving waterbodies. Third, routine monitoring is needed for toxin mixtures at the land–sea interface including algal toxins of marine origins as well as cyanotoxins that are sourced from inland freshwater or produced in estuaries. Case studies from California are presented to illustrate the implementation of these recommendations, but these recommendations can also be applied to inland states or regions where the downstream receiving waterbody is a freshwater lake, reservoir, or river. Integr Environ Assess Manag 2023;19:586–604. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Incidence and management of pleural effusions in patients with Wilms tumor: A Pediatric Surgical Oncology Research Collaborative study
Authors: Al‐Hadidi Ameer , Rinehardt Hannah N. , Sutthatarn Pattamon , Talbot Lindsay J. , Murphy Andrew J. , Whitlock Richard , Condon Sienna , Naik‐Mathuria Bindi , Utria Alan F. , Rothstein David H. , Chen Stephanie Y. , Wong‐Michalak Shannon , Kim Eugene S. , Short Scott S. , Meyers Rebecka L. , Kastenberg Zachary J. , Johnston Michael E. , Zens Tiffany , Dasgupta Roshni , Malek Marcus M. , Calabro Kristen , Piché Nelson , Callas Hannah , Lautz Timothy B. , McKay Katlyn , Lovvorn Harold N. , Commander Sarah Jane , Tracy Elisabeth T. , Lund Sarah B. , Polites Stephanie F. , Davidson Jacob , Dhooma Janel , Seemann Natashia M. , Marquart John P. , Gainer Haley , Lal Dave R. , Rich Barrie S. , Glick Richard D. , Maloney Lauren , Radu Stephani , Fialkowski Elizabeth A. , Kwok Pei En , Romao Rodrigo L. P. , Rubalcava Nathan , Ehrlich Peter F. , Newman Erika , Diehl Thomas , Le Hau D. , Polcz Valerie , Petroze Robin T. , Stanek Joseph , Aldrink Jennifer H. 
Published: June 2022

AbstractWilms tumor (WT) is the most common renal malignancy in children. Children with favorable histology WT achieve survival rates of over 90%. Twelve percent of patients present with metastatic disease, most commonly to the lungs. The presence of a pleural effusion at the time of diagnosis of WT may be noted on staging imaging; however, minimal data exist regarding the significance and prognostic importance of this finding. The objectives of our study are to identify the incidence of pleural effusions in patients with WT, and to determine the potential impact on oncologic outcomes. A multi‐institutional retrospective review was performed from January 2009 to December 2019, including children with WT and a pleural effusion on diagnostic imaging treated at Pediatric Surgical Oncology Research Collaborative (PSORC) participating institutions. Of 1259 children with a new WT diagnosis, 94 (7.5%) had a pleural effusion. Patients with a pleural effusion were older than those without (median 4.3 vs 3.5 years; P = .004), and advanced stages were more common (local stage III 85.9% vs 51.9%; P < .0001). Only 14 patients underwent a thoracentesis for fluid evaluation; 3 had cytopathologic evidence of malignant cells. Event‐free and overall survival of all children with WT and pleural effusions was 86.2% and 91.5%, respectively. The rate and significance of malignant cells present in pleural fluid is unknown due to low incidence of cytopathologic analysis in our cohort; therefore, the presence of an effusion does not appear to necessitate a change in therapy. Excellent survival can be expected with current stage‐specific treatment regimens.