bluuebunny/crossref_metadata_2025_split huggingface dataset:
Verbesserte Patientenversorgung und effizientere Zusammenarbeit zwischen Apotheken und Pflegediensten durch maschinelle Medikamentenverblisterung und die Vernetzungsplattform MediMan: Eine Fallstudie
Authors: Kajüter Patricia , Behne Alina , Teuteberg Frank 
Published: May 2022

ZusammenfassungPflegebedürftige können ihre Medikamente oft nicht selbstständig stellen, deshalb wird dies durch geschultes Fachpersonal ambulanter Pflegedienste übernommen. Dieser Prozess ist fehleranfällig, denn die Medikamente werden häufig manuell und in der Nachtschicht vom Pflegefachpersonal zusammengestellt. Hierdurch kann es zu Risiken wie Doppelmedikationen und unberücksichtigten Wechselwirkungen unterschiedlicher Medikamente kommen. Zudem ist dieser Prozess nicht ressourceneffizient und durch den bereits bestehenden Fachkräftemangel nicht tragbar. Durch die vergleichsweise geringe digitale Vernetzung im deutschen Gesundheitswesen gibt es bei der interprofessionellen Zusammenarbeit zwischen Apotheken, Pflegediensten, Blisterzentren und Arztpraxen weiteren Verbesserungsbedarf. Ziel dieses Beitrags ist es daher aufzuzeigen, welche Erkenntnisse und Handlungsbereiche sich aus einer Fallstudie zur digitalen Vernetzungsplattform MediMan ableiten lassen und wie in diesem Zusammenhang die maschinelle Medikamentenverblisterung dazu beitragen kann, die interprofessionelle Zusammenarbeit zwischen Apotheken, Pflegediensten, Blisterzentren und Arztpraxen durch eine sichere und effiziente Patientenversorgung zu führen. Anhand einer Prozessmodellierung, basierend auf Experteninterviews und Fokusgruppen mit Stakeholdern aus dem Gesundheitswesen, wird aufgezeigt, welche Potenziale sich aus der maschinellen Verblisterung in Kombination mit einer Vernetzungsplattform ergeben. Als Ergebnis lassen sich acht Erkenntnisse bzw. Handlungsbereiche ableiten, die in diesem Beitrag vertiefend vorgestellt werden: (1) Prozessvereinfachung, (2) Plattformerprobung, (3) Abstimmungsbedarfe, (4) Mitarbeitereinbindung und -schulung, (5) Informationsverbreitung, (6) Vergütungsregelungen, (7) Schnittstelle Warenwirtschaftssystem sowie (8) Interoperabilität und Telematikinfrastruktur.
A highly attenuated Vesiculovax vaccine rapidly protects nonhuman primates against lethal Marburg virus challenge
Authors: Woolsey Courtney , Cross Robert W. , Agans Krystle N. , Borisevich Viktoriya , Deer Daniel J. , Geisbert Joan B. , Gerardi Cheryl , Latham Theresa E. , Fenton Karla A. , Egan Michael A. , Eldridge John H. , Geisbert Thomas W. , Matassov Demetrius 
Published: May 2022

Background
Marburg virus (MARV), an Ebola-like virus, remains an eminent threat to public health as demonstrated by its high associated mortality rate (23–90%) and recent emergence in West Africa for the first time. Although a recombinant vesicular stomatitis virus (rVSV)-based vaccine (Ervebo) is licensed for Ebola virus disease (EVD), no approved countermeasures exist against MARV. Results from clinical trials indicate Ervebo prevents EVD in 97.5–100% of vaccinees 10 days onwards post-immunization.

Methodology/Findings
Given the rapid immunogenicity of the Ervebo platform against EVD, we tested whether a similar, but highly attenuated, rVSV-based Vesiculovax vector expressing the glycoprotein (GP) of MARV (rVSV-N4CT1-MARV-GP) could provide swift protection against Marburg virus disease (MVD). Here, groups of cynomolgus monkeys were vaccinated 7, 5, or 3 days before exposure to a lethal dose of MARV (Angola variant). All subjects (100%) immunized one week prior to challenge survived; 80% and 20% of subjects survived when vaccinated 5- and 3-days pre-exposure, respectively. Lethality was associated with higher viral load and sustained innate immunity transcriptional signatures, whereas survival correlated with development of MARV GP-specific antibodies and early expression of predicted NK cell-, B-cell-, and cytotoxic T-cell-type quantities.

Conclusions/Significance
These results emphasize the utility of Vesiculovax vaccines for MVD outbreak management. The highly attenuated nature of rVSV-N4CT1 vaccines, which are clinically safe in humans, may be preferable to vaccines based on the same platform as Ervebo (rVSV “delta G” platform), which in some trial participants induced vaccine-related adverse events in association with viral replication including arthralgia/arthritis, dermatitis, and cutaneous vasculitis.
Performance of a rapid immuno-chromatographic test (Schistosoma ICT IgG-IgM) for detecting Schistosoma-specific antibodies in sera of endemic and non-endemic populations
Authors: Hoermann Julie , Kuenzli Esther , Schaefer Carmen , Paris Daniel H. , Bühler Silja , Odermatt Peter , Sayasone Somphou , Neumayr Andreas , Nickel Beatrice 
Published: May 2022

Background
Schistosomiasis, an acute and chronic parasitic disease caused by human pathogenic Schistosoma species, is a neglected tropical disease affecting more than 220 million people worldwide.
For diagnosis of schistosomiasis, stool and urine microscopy for egg detection is still the recommended method, however sensitivity of these methods is limited. Therefore, other methods like molecular detection of DNA in stool, detection of circulating cathodic antigen in urine or circulating anodic antigen in urine and serum, as well as serological tests have gained more attention. This study examines the sensitivity and specificity of a rapid diagnostic test based on immunochromatography (Schistosoma ICT IgG-IgM, LD Bio, Lyon, France) for simultaneous detection of specific IgG and IgM antibodies in serum, against Schistosoma spp. in endemic and non-endemic populations.

Methodology/Principal findings
Frozen banked serum samples from patients with confirmed schistosomiasis, patients with other helminth infections, patients with seropositive rheumatoid arthritis and healthy blood donors were used to assess the sensitivity and the specificity of the Schistosoma ICT IgG-IgM rapid diagnostic test.
The test showed a sensitivity of 100% in patients with parasitologically confirmed schistosomiasis, irrespective of the species (S. mansoni, S. haematobium, S. japonicum, S. mekongi). In healthy blood donors and patients with rheumatoid factor positive rheumatoid arthritis from Europe, specificity was 100%. However, in serum samples of patients with other tissue invasive helminth infections, the test showed some cross-reactivity, resulting in a specificity of 85%.

Conclusion/Significance
With its high sensitivity, the Schistosoma ICT IgG-IgM rapid diagnostic test is a suitable screening test for detection of Schistosoma specific antibodies, including S. mekongi. However, in populations with a high prevalence of co-infection with other tissue invasive helminths, positive results should be confirmed with other diagnostic assays due to the test’s imperfect specificity.
The efficacy of oxidized regenerated cellulose (SurgiGuard®) in breast cancer patients who undergo total mastectomy with node surgery: A prospective randomized study in 94 patients
Authors: Nam Kug Hyun , Lee Joon-Hyop , Chung Yoo Seung , Chun Yong Soon , Park Heung Kyu , Kim Yun Yeong 
Published: May 2022

Background
Seromas frequently develop in patients who undergo total mastectomy with node surgery. We aimed to prospectively explore whether use of oxidized regenerated cellulose (ORC, SurgiGuard®) affects seroma formation after total mastectomy with node surgery (sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND)).

Materials and methods
Ninety four breast cancer patients were enrolled in the study who underwent total mastectomy with ALND or SLNB. The patients were randomized into two groups, one treated with ORC plus closed suction drainage and the other with closed suction drainage alone.

Results
Mean drainage volume was slightly lower in the ORC group on postoperative day 1 (123 ± 54 vs 143 ± 104 ml), but was slightly higher at all other time points; however, these differences were not significant. Mean total drainage volume in patients treated with ORC plus drainage did not differ from that of patients treated with drainage alone (1134 ± 507 ml vs 1033 ± 643 ml, P = 0.486).

Conclusions
Use of ORC (SurgiGuard®) did not significantly alter the risk of seroma formation.
A qualitative analysis of electronic nicotine delivery systems (ENDS) uptake and use among young adult never-smokers in New Zealand
Authors: Robertson Lindsay , Hoek Janet , Blank Mei-Ling 
Published: May 2022

Introduction
Electronic nicotine delivery systems (ENDS) likely pose fewer health risks than smoking. Yet ENDS uptake has increased among never-smoking young adults, who likely face greater health risks relative to non-users of ENDS. To date, few qualitative studies have explored ENDS uptake and use by never-smokers.

Methods
We conducted in-depth, semi-structured interviews with 16 current ENDS users from New Zealand aged 18 to 24 years old who reported never having smoked cigarettes regularly. We explored participants’ experimentation with conventional tobacco products, trial, uptake and patterns of ENDS use, and their future intentions regarding both ENDS and conventional tobacco products. We managed the data using NVivo12 and used thematic analysis to interpret the transcripts.

Results
ENDS use enhanced connection and belonging by providing communal experiences and facilitating social interactions. Participants’ mastery of tricks generated social cachet within friendship groups and counteracted the ENDS-related stigma they experienced. Flavours, clouds and devices’ physical attributes provided stimulation and engagement, and some used ENDS for stress or appetite management. Lastly, participants rationalised ENDS uptake by referencing the far greater risks smoking posed.

Conclusions
ENDS uptake by young adult never-smokers is driven by both psycho-social and functional factors. ENDS provided shared hedonic experiences and physical pleasures, and generated both bonding and bridging social capital, although many participants had also experienced judgement from others for using ENDS. Policies that denormalise ENDS as recreational devices could discourage uptake by never-smokers, though measures will require careful nuancing to avoid deterring smokers from switching to ENDS.
Implementation of the ERAS (Enhanced Recovery After Surgery) protocol for hysterectomy in the Piedmont Region with an audit&feedback approach: Study protocol for a stepped wedge cluster randomized controlled trial. A study of the EASY-NET project
Authors: Piovano Elisa , Pagano Eva , Del Piano Elena , Rinaldi Federica , Palazzo Valentina , Coata Paola , Bongiovanni Daria , Rolfo Monica , Ceretto Giannone Laura , Veliaj Deliana , Camanni Marco , Puppo Andrea , Ciccone Giovannino ,   the ERAS-Gyneco Piemonte group
Published: May 2022

Introduction
ERAS (Enhanced Recovery After Surgery) is a perioperative program combining multiple evidence-based interventions designed to reduce the surgical stress response. Despite the publication of dedicated guidelines, ERAS application to gynecologic surgery outside clinical studies has been slow and fragmented. To promote the systematic adoption of the ERAS program in the entire regional hospital network in Piedmont an Audit-and-Feedback approach (A&F) has been adopted within a cluster randomized controlled trial, aiming to estimate the true impact of the protocol on a large, unselected population.

Methods
The study protocol provides for a multicenter stepped wedge cluster randomized trial, focused on women undergoing an hysterectomy, for comparison between standard perioperative management and perioperative management according to the ERAS protocol. The primary outcome is the length of hospital stay (LOS). Secondary outcomes are: post-operative complications, quality-of-recovery at 24-hours after surgery, 30-day readmissions, patients’ satisfaction, healthcare costs. The compliance to all the ERAS items is monitored with an A&F approach. All the gynecologic units of Piedmont hospitals are involved and all the patients hospitalized for elective hysterectomy in the period of the study are included. Centers, stratified by surgical volume and randomly assigned to four groups, are randomly ordered to activate the ERAS protocol in four periods, every three months. The planned calendar and the total duration of the study have been extended for six months due to the COVID-19 pandemic. The expected sample size of about 2400 patients has a high statistical power (99%) to detect a reduction of LOS of 1 day (effect size 0.5) and to estimate clinically meaningful changes in the other study endpoints. The study protocol has been approved by the Ethical Committee of all participating centers. Study results will be timely circulated within the hospital network and published in peer-reviewed journals.

Conclusion
Results are expected to demonstrate positive clinical outcomes of the ERAS protocol even when its implementation is directed towards an entire regional network of gynecologic units, and not only towards selected and highly motivated centers.

Trial registration
NCT04063072
Breast cancer screening practices among Vietnamese women and factors associated with clinical breast examination uptake
Authors: Ngan Tran Thu , Jenkins Chris , Minh Hoang Van , Donnelly Michael , O’Neill Ciaran 
Published: May 2022

Background
This study examined current breast cancer (BC) screening practices among Vietnamese women and the factors associated with the uptake of clinical breast examination (CBE).

Methods
A total of 508 women aged 30–74 years in Hanoi completed a knowledge-attitude-practice (KAP) survey in 2019 including validated measures of breast cancer awareness (Breast-CAM) and health beliefs (Champion’s Health Belief Model Scale). Descriptive statistics, χ2, and ANOVA tests were used to analyse KAP responses across groups with different sociodemographic characteristics. A logistic regression model assessed the associations of knowledge, beliefs, and sociodemographic characteristics with CBE uptake.

Results
Only 18% of respondents were aware of BC signs, risk factors, and screening modalities although 63% had previously received BC screening. CBE was the most common screening modality with an uptake of 51%. A significantly higher proportion of urban residents compared with rural residents (32% vs 18%, Chi-square test, p = 0.04) received mammography. Unlike mammography, CBE uptake was not associated with sociodemographic characteristics (i.e., residence area/education level/occupation/household monthly income/possession of health insurance). CBE uptake was associated with BC knowledge (OR = 2.44, 95%CI: 1.37–4.32), perceived susceptibility to BC (OR = 1.15, 95%CI: 1.05–1.25), and perceived barriers to accessing CBE (OR = 0.88, 95%CI: 0.84–0.92).

Conclusion
The study points to the need for public health education and promotion interventions to address low levels of awareness about BC and to increase uptake of BC screening in Vietnam in advance of screening programme planning and implementation. It also suggests that screening programmes using CBE are promising given current engagement and the absence of socio-demographic disparities.
Actualización en el tratamiento del hipoparatiroidismo posquirúrgico
Authors: Ventosa-Viña Marta , Cuéllar-Olmedo Luis , Crespo-Soto Cristina , Palacio-Mures José María , García-Duque María , Lázaro-Martín Lucía 
Published: May 2022

Introducción y objetivo: El hipoparatiroidismo posquirúrgico es una complicación frecuente de la cirugía tiroidea y paratiroidea, con consecuencias significativas sobre la salud y calidad de vida. El objetivo de esta revisión es proporcionar una visión actualizada de su prevención, detección precoz y tratamiento.
Síntesis: Tras la tiroidectomía y paratiroidectomía puede aparecer hipoparatiroidismo de forma aguda, especialmente en algunos pacientes de alto riesgo. La determinación de la hormona paratiroidea intacta (PTHi) en el postoperatorio temprano es una herramienta útil en el manejo del paciente. Un nivel de PTHi postoperatoria <10-15 pg/ml, combinado con los niveles de calcemia 24 horas después de la cirugía, ofrece el mejor valor predictivo para hipocalcemia aguda. El hipoparatiroidismo permanente se asocia con morbilidad y deterioro de calidad de vida a largo plazo y debería prevenirse cuando sea posible. El tratamiento convencional incluye calcio oral y metabolitos activos de vitamina D. En caso de hipocalcemia severa o sintomática se precisa calcio intravenoso. El tratamiento debe monitorizarse e incluir educación sanitaria del paciente, para evitar amplias desviaciones de la calcemia. Sin embargo, con la terapia convencional mantener un adecuado control puede representar un desafío. La terapia sustitutiva con hormona paratiroidea recombinante (rhPTH) puede reducir las dosis de calcio y calcitriol necesarias, manteniendo la calcemia y fosfatemia dentro de los rangos recomendados. También parece mejorar el metabolismo óseo y la calidad de vida a largo plazo. Se precisa más información en cuanto a eficacia y seguridad con esta terapia.
Conclusiones: El hipoparatiroidismo posquirúrgico es frecuente. Requiere un diagnóstico temprano, intervención farmacológica y educación del paciente para alcanzar un control óptimo y disminuir el riesgo de complicaciones a largo plazo. La rhPTH parece una opción prometedora para aquellos pacientes que no mantienen la calcemia dentro del objetivo.
Saúde e Segurança do Trabalho
Authors: Souza Luan Amaral de 
Published: May 2022

Este trabalho estudou a caracterização de atividades laborais em contato permanente com pacientes portadores de doenças infectocontagiosas, durante o contexto de pandemia do Covid-19 no Brasil, tendo em vista legislação aplicável. Analisou-se a incidência de litígios na Justiça do Trabalho, por descumprimento às legislações de higiene ocupacional. Por fim, caracterizou-se a exposição de trabalhadores a ambientes insalubres, durante a pandemia do coronavírus no Brasil. No período avaliado, verificou-se a publicação de diversos atos normativos de combate à pandemia no Brasil, de autoria do Estado, em todos os âmbitos. Verificou-se que as consequências da inobservância das normas de higiene ocupacional resultaram em altos índices de ações trabalhistas, assim é preciso adotar medidas preventivas de combate ao Covid-19 e evitar passivos trabalhista.
Nota da Editora
Authors: Cardoso Squeff Tatiana de A. F. R. 
Published: May 2022

Apresenta a edição n. 2 do vol. 49 da Revista da Faculdade de Direito da Universidade Federal de Uberlândia, relembrando que a colonialidade presente nas relações sociais nos dias atuais também é vislumbrada no campo editorial na medida em que as publicações de grande circulação – e citação – normalmente estão redigidas em línguas estrangeiras, especialmente em inglês, assim como são veiculadas por periódicos internacionais, vinculados a festejadas instituições europeias ou estadunidenses. Logo, estimular a publicação de textos assinados por autores brasileiros e de outras nações não-centrais do sistema-mundo, vinculados a instituições nacionais ou mesmo forasterias, em idiomas latinos ou não-predominantes, mostra-se essencial para a disseminação de um conhecimento deslocalizado subjetiva e epistemologicamente, porém de qualidade, que possa colaborar para com a reflexão do mundo hodierno desde outras visões, com vistas a compreendê-lo e melhorá-lo.
Les catégories de l’entendement managérial pour la « gestion de la relation client » dans une caisse primaire d’assurance maladie en France
Authors: Martin Pascal 
Published: May 2022

« La gestion à la relation client » s’est imposée à l’accueil de l’assurance maladie depuis vingt ans, dans un contexte de transformations visant à réformer et « moderniser » les services publics sans renoncer à la logique de réduction des effectifs. Elle dessert les populations les plus précaires pour l’accès à une couverture maladie. La formation dispensée aux agents d’accueil les porte à (dé)classer les différentes catégories d’usagers pour s’ajuster aux normes locales de la gestion des flux. Des jugements sociaux et moraux, fondés par le discours hiérarchique dominant, président à la légitimation de la « gestion à la relation client » à l’accueil où affluent des « populations en difficulté ». Cette rhétorique influe sur les façons de penser et d’agir des agents d’accueil. Les données présentées ici ont été recueillies lors d’une enquête ethnographique réalisée au sein d’un organisme de Sécurité sociale de la région parisienne.
Knowledge and perceptions of adverse childhood experiences (ACEs) among prelicensure nursing students
Authors: George Tracy P. , Kershner Sarah H. , Hucks J. Marty , DeCristofaro Claire 
Published: May 2022

AbstractObjectivesAdverse childhood experiences (ACEs) impact health outcomes in adulthood. Positive childhood experiences (PCEs) are associated with resiliency and improved mental and physical health outcomes. There is often a lack of content on ACEs in nursing education. The purpose of this project was to determine the knowledge and perceptions of ACEs and PCEs among prelicensure nursing students.MethodsA mixed-method pilot study was implanted. Prelicensure nursing students received didactic instruction on ACEs and PCEs and completed online, anonymous ten-item pre- and post-surveys about knowledge on ACEs and PCEs.ResultsA positive percent change was observed with all ten statements from pre- to post-surveys. Six themes emerged from qualitative analysis, revealing the importance and benefits of education on ACEs and PCEs.ConclusionsThis study shows that nursing students valued education regarding ACEs, were willing to incorporate their knowledge of ACEs into their practice, and discovered they might have been exposed to ACEs themselves. Implications for International Audience: All nursing programs must include content on ACEs and PCEs to prepare better nurses to care for patients.
IoT-enabled edge computing model for smart irrigation system
Authors: Premkumar S. , Sigappi AN. 
Published: May 2022

Abstract
Precision agriculture is a breakthrough in digital farming technology, which facilitates the application of precise and exact amount of input level of water and fertilizer to the crop at the required time for increasing the yield. Since agriculture relies on direct rainfall than irrigation and the prediction of rainfall date is easily available from web source, the integration of rainfall prediction with precision agriculture helps to regulate the water consumption in farms. In this work, an edge computing model is developed for predicting soil moisture in real time and managing the water usage in accordance with rain prediction. A soil moisture prediction hybrid algorithm (SMPHA) has been developed that revolves around the decision-making techniques with live environmental parameters including weather parameters for the prediction of soil moisture through the impact of precipitation. Numerous algorithms with the combination of regression + clustering are estimated, and it is inferred that XGBoost + k-means outperforms other algorithmic combinations that is deployed in edge model. This model is used as an intermediary between the end IoT devices and cloud that results in the saving of computationally intensive processing performed on cloud servers. The servers located on a local edge network perform the developed algorithmic computations. Avoiding transmission over the cloud results in significant latency, response time, and computation power savings and therefore increases the efficiency of data transfer. The proposed edge computing model is implemented in Raspberry Pi as an edge, Heroku as cloud, and edge nodes as the combination of Pi with actuators and sensors. The monitored data from Pi are stored in MongoDB webserver that is controlled by Web dashboard. Finally, the developed model is implemented in cloud and edge where the edge server implementation performs better in terms of latency, bandwidth, throughput, response time, and CPU memory usage.