bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of infrasound exposure and glucose intolerance on bone composition in Wistar rats
Authors: Zagalo Luísa , Pereira Gonçalo , Casal Diogo , Gonçalves Luísa L. , Zagalo Carlos , Oliveira Maria João , Oliveira Pedro , Brito José A. A. 
Published: March 2022

Abstract
Introduction: The concentrations of some chemical elements may differ between healthy and diseased tissues. The knowledge of these differences is pivotal to understand the metabolic processes involved in both physiological and diseased states. The aim of this study was to evaluate the elemental composition of calcium (Ca) and phosphorus (P) in the bone of rats subjected to glucose intolerance and/or infrasound.Materials and Methods: X-ray fluorescence spectroscopy was applied in the concentration determination of Ca and P in samples of Wistar rat tibiae. Tibiae from glucose intolerant, non-intolerant, exposed and non-exposed to infrasound rats were analysed.Results: There was a significant decrease in bone P concentration in glucose intolerant rats compared to non-intolerant animals. Similarly, the Ca/P ratio was higher in glucose intolerant animals. There were no significant differences for bone Ca concentration in both studied groups, nor between animals exposed and non-exposed to infrasound in either studied element.Discussion and Conclusions: Glucose intolerant rats had lower bone P concentration and unaltered bone Ca concentration compared to non-glucose intolerant rats. Infrasound exposure was not associated to changes of bone Ca or P. The reduction of bone P concentration may be associated with the augmented risk of bone fractures in diabetes.
Association Of Potassium Concentration And Variability With Mortality Among Patients Requiring Continuous Renal Replacement Therapy In Intensive Care Units: A Hospital-Based Retrospective Cohort Study
Authors: Mao I-Chieh , Lin Pei-Ru , Wu Shin-Hwar , Hsu Hsin-Hui , Hung Pei-Shan , Kor Chew-Teng 
Published: March 2022

Abstract
Background: Serum potassium between 3.5 to 5.0 mmol/L is known to be a safe range for patients. The optimal serum potassium level for critically-ill patients with acute kidney injury undergoing continuous renal replacement therapy (CRRT) remains uncertain. This retrospective analysis investigated the association between ICU mortality and potassium concentrations and variability. Methods: ICU patients aged 20 or older, with a minimum of two serum potassium values during received CRRT, treated in ICU in a tertiary hospital in central Taiwan between 1 January 2010 and 30 April 2021 were eligible for inclusion. Patients were categorized into groups of mean potassium: <3.0, 3.0 to <3.5, 3.5 to <4.0, 4.0 to <4.5, 4.5 to <5.0, and ³5.0 mmol/L; potassium variability was divided by quartiles of the average real variation. We analyzed the association between potassium concentration and variability with mortality and performed Cox’s proportional hazard models.Results: We studied 1991 CRRT patients with 9891 serum potassium values within 24 hours after receiving CRRT. There was a J-shaped association between serum potassium and mortality, with the lowest mortality observed in patients with mean potassium concentrations between 3.0 and 4.0 mmol/L. The risk of in-hospital death was also significantly increased in those with the highest variability [HR and 95% CI=1.31(1.03-1.65) for in-hospital mortality; 1.39(1.06-1.82) for 28-day mortality and 1.43(1.11-1.83) for 90-day mortality, respectively].Conclusions: Patients receiving CRRT may benefit from a lower and tighter serum potassium control. During CRRT, progressively increased mortality was noted in patients with higher potassium variability. Thus, careful and timely correction of dyskalemia among these patients is particularly important.
Bioinformatic analysis for the identification of potential gene targeting drug resistance in CRC
Authors: Zhou Zhengyang , Zhang Yan , Yang Changliang , Yang Haiou , Yang Jiayu , Zhang Haiyang , Ba Yi 
Published: March 2022

Abstract
Background
Colorectal cancer (CRC) is one of the most common malignant tumors in the world, and chemotherapy is an effective treatment against it. However, the occurrence of drug resistance has always been a big problem hindering the treatment.
Methods
We used bioinformatics analysis to identify potential key genes and pathways to further understand the mechanism of oxaliplatin resistance in this study. GSE69657 was an expression profile dataset of advanced CRC patients receiving standard FOLFOX chemotherapy, which was used to identify differentially expressed genes (DEGs). Enriched terms and pathways were determined by gene ontology (GO) and Kyoto Encyclopedia of Genes (KEGG) analyses. The key modules and hub genes involved in oxaliplatin resistance were identified by protein-protein interaction (PPI) analysis.
Results
A total of 232 DEGs were identified. In Go biological process, cellular component, and molecular function analyses, muscle contraction, contractile fiber, and structural constituent of muscle were enriched obviously. The most significantly enriched pathway was vascular smooth muscle contraction. And we found that smooth muscle contraction, muscle contraction may be the critical module in the PPI network analysis. Ten up-regulated hub genes, including TPM1, TPM2, and MYH11, may play an important role in the chemotherapy resistance of CRC. In the transcription factors (TF) prediction, we also found that the serum response family (SRF) was involved in chemotherapeutic resistance. These hub genes and TF identified by us may be potential targets for reversing drug resistance of CRC.
Conclusions
A number of hub genes such as TPM1, TPM2 and MYH11, as well as smooth muscle contraction, muscle contraction played a crux role in drug resistance of CRC. They may be a novel target to reverse tumor drug resistance and function importantly in clinical treatment in the future.
Prioritization of Intervention Domains to Prevent Cardiovascular Disease: A Country-Level Case Study using Global Burden of Disease and Local Data
Authors: Wilson Nick , Cleghorn Christine , Nghiem Nhung , Blakely Tony 
Published: March 2022

Abstract
Aim: We aimed to combine Global Burden of Disease (GBD) Study data and local data to identify the highest priority intervention domains for preventing cardiovascular disease (CVD) in the case study country of Aotearoa New Zealand (NZ).
Methods: Risk factor data for CVD in NZ was extracted from the GBD using the “GBD Results Tool”. We prioritized risk factor domains based on consideration of the size of the health burden (disability-adjusted life years [DALYs]) and then by two alternative ways: (i) strength of the evidence-base for domain-specific interventions being cost-saving (based on number of NZ publications); and (ii) the domain-specific interventions that delivered the highest health gains and cost-savings.
Results: Based on the size of the CVD health burden in DALYs, the five top prioritized risk factor domains were: high systolic blood pressure (84,800 DALYs; 5400 deaths in 2019), then dietary risk factors, then high LDL cholesterol, then high BMI and then tobacco (30,400 DALYs; 1400 deaths). When considering strength of evidence-base around health economic benefits, we found that tobacco control could be considered to be the highest priority risk factor domain to intervene in (nine NZ publications showing cost-savings). But if policy-makers aimed to maximize health gain and cost-savings from specific interventions that have been studied, then they would favor the dietary risk domain (e.g., a combined fruit and vegetable subsidy plus a sugar tax produced estimated lifetime savings of 894,000 health-adjusted life years and health system cost-savings of US$11.0 billion). Other potential considerations for prioritization are: (i) the potential for total health gain that includes non-CVD health loss (i.e., again favoring tobacco control); (ii) potential for achieving relatively greater per capita health gain for Māori (Indigenous) to reduce health inequities; and (iii) consideration of co-benefits such as greenhouse gas reductions from dietary interventions.
Conclusions: We were able to show how CVD risk factor domains could be systematically prioritized using a mix of GBD and country-level data. Tobacco control could be top ranked if policy-makers focused on the strength of evidence for health economic benefits. But if policy-makers wished to maximize health gain and cost-savings from any specific intervention/s, then they may favor dietary interventions e.g., food taxes and subsidies.
Combining ability and performance of three-way maize hybrids for grain yield and resistance to maize lethal necrosis under contrasting environments
Authors: Awata Luka , Ifie Beatrice , Danquah Eric , Jumbo MacDonald Bright , Suresh LM , Gowda Manje , Marchelo-Dragga Philip , Olsen Michael , Prasanna Boddupalli , Tongoona Pangirayi Bernard 
Published: March 2022

Abstract
Combining ability studies have been extensively used to assess gene action responsible for various traits including disease resistance in maize. Some backcross (BC 3 F 2 ) and dihaploid (DH) lines developed through marker assisted selection have not been tested for their yield performances in hybrid combinations. A total of 16 BC 3 F 2 lines and their parental checks and 60 DH lines including lines and their parental checks were crossed to two single cross testers (CML312/CML442 and CML395/CML444) using Line x Tester design. The 152 three-way hybrids generated were evaluated for yield performance and other agronomic traits under artificial MLN inoculation, low nitrogen soil and optimum conditions in Kenya and South Sudan in 2019. Significant genotype, GxE, general combining ability (GCA) and specific combining ability (SCA) effects ( p ≤0.01) were detected for grain yield (t/ha) and maize lethal necrosis (MLN) scores. GCA effects were preponderant over SCA effects for most traits. High broad sense and moderate narrow sense heritability estimates for all traits across management options were detected. This implied that these traits could be improved through recurrent selection. DH lines D3, D14, D57 and BC 3 F 2 lines BCL3, BCL5, BCL8 showed desirable GCA effects for MLN resistance and grain yield. DH derived hybrids DH70, DH43, DH18 and DH40; and backcross (BC) derived hybrids BH28 and BH01 demonstrated desirable SCA effects for the same traits. Deployment of these MLN resistant lines into breeding programmes should result into improved MLN resistance and increased grain yields. The superior hybrids will provide desirable options for farmers who continue to experience low average maize yields due to MLN infections.
Screening and characterization of Lipopeptide Biosurfactant Producing Paenibacilus Dendritiformis and its applicability for enhanced oil recovery
Authors: Nayarisseri Anuraj , Khandelwal Ravina , Singh Sanjeev Kumar 
Published: March 2022

Abstract
The biosurfactants produced by microorganisms have high demand from microbial-enhanced oil recovery (MEOR) and they have focused on a chemical surfactant for the past few decades for degrading petro-based pollutants and oil spills due to its non-toxicity and increasing bioavailability. The study aims to identify and screen potential lipopeptide biosurfactant produced by Paenibacillus species employing a design experiment based on RSM. The bacterial culture was isolated from Chilika Lake, India. The data generated from the biosurfactant stability experiments were used to fit a regression model using the parameters such as ph, temp, and salinity to predict the E24 index. R-squared value 0.91 obtained from the ANOVA model explains that the regression model was significant, and the model p-value obtained was < 0.05 and was also statistically significant. Therefore the statistical regression model obtained in the present investigation can predict the E24 index by using any combination of ph, temp, and salinity parameters. The novel isolates obtained in this research were further named Paenibacillus dendritiformis ANSKLAB02 and deposited in GenBank with accession number KU518891. The growth of this species under controlled conditions has a high potential to help in environmental clean-up and is suitable for use in MEOR applications.
Strongly Connected Ramanujan Graphs for Highly Symmetric LDPC Codes
Authors: Al-Hamdani Hussein , Almamori Aqiel , Mohan Seshadri 
Published: March 2022

Abstract
A number of studies focus on Low-Density Parity-Check (LDPC) codes to ensure reliable data communications. This study proposes an algebraic algorithm to generate strongly connected Ramanujan graphs able to provide highly symmetric LDPC codes with minimized error floor. Several Ramanujan graphs are created using GAP system software to generate a rank-efficient parity-check matrix with fixed-rate LDPC codes. We find that Ramanujan LDPC codes achieve frame error rate and bit error rate on the order of \({10}^{-5}\) and \({10}^{-6}\), respectively. Furthermore, the codes outperform QC LDPC codes and those Ramanujan LDPC codes in literature.
Energy and reliability analysis of wastewater treatment plants in small communities in Ontario
Authors: Hamza Rania , Hamoda Mohamed F. , Elassar Mohammad 
Published: March 2022

Abstract
This paper presents energy and reliability analyses of eight wastewater treatment plants (WWTPs) operating in small communities in Ontario, Canada, with rated capacities ranging from 60 to 4,400 m3/d. Five different treatment technologies were investigated, namely, rotating biological contactor (RBC), sequencing batch reactor (SBR), membrane bioreactor (MBR), lagoon, and extended aeration activated sludge process (EAAS). Energy benchmarking based on key performance indicators (KPIs) was used to quantify the specific consumption of energy in WWTPs per unit of the pollutant removed. The overall annual electrical energy consumption was correlated to the volume of treated wastewater, the population equivalent, and the amounts of TSS and BOD removed. The RBC plants showed a distinctive advantage for all energy KPIs assessed, while SBR plants yielded the highest values of energy KPIs. Analyses of the expected percentage of compliance with discharge standards and the coefficient of reliability (COR) based on the WWTPs' performance records showed that few WWTPs were able to achieve reliability levels over 95%, considering the mandated discharge standards under the current operating and maintenance conditions. Within each technology, the treatment train, operating conditions, maintenance level, and age of infrastructure were important elements that contributed to the large variability observed.
Usage of Traditional, Complementary and Alternative Medicine and Related Factors among Patients Receiving Healthcare in Lesotho
Authors: Mokhesi Thuso , Modjadji Perpetua 
Published: March 2022

Background:
The use of Traditional, Complementary and Alternative Medicine (TCAM) is becoming apparent among many populations, particularly those suffering from chronic illnesses. Although this is a concern to clinicians, especially on safety and potential health risks, there is a paucity of data on TCAM usage and related factors among patients receiving healthcare in Lesotho.

Objective:
To determine the prevalence of TCAM usage and associated factors among patients receiving healthcare in a health facility in Lesotho.

Methods:
A cross-sectional study was conducted among 336 patients receiving healthcare in the Maseru district, Lesotho. A validated questionnaire was used to collect data on demographic and lifestyle factors, disease and treatment profile, treatment challenges, and TCAM usage, reasons/purpose, disclosure, healing system, duration, costs, sources and types. Multiple logistic regression analysis was used to ascertain any relationships with TCAM usage.

Results:
The response rate was 98%. The mean age of participants was 51±16years. Unemployment (63%) was high and, over half of the patients (59%) attained primary school education. Patients were mostly on treatment for sexually transmitted infections (42%), non-communicable diseases (30%) and comorbidities (19%), with 98% taking prescribed medication. TCAM usage was 15% with Traditional Herbal Medicine (THM) being the most widely used. Common THM were Dicoma Anomala, Eriocephalus Punctulatus, Aloiampelos Striatula, Artemisia Afra and Allium Sativum, obtained from the traditional healers (53%), followed by relative/friends (16%), pharmacists (13%), open market (12%), and accessed at low costs. TCAM was used to treat infectious (23%) and non-infectious (77%) diseases, but disclosure (7%) to healthcare workers was low. Multivariate analysis showed that TCAM usage was associated with self-employment AOR=6.3, 95%CI; 2.57-15.21, and being a student AOR=3.6, 95%CI; 0.99–12.71.

Conclusion:
THM was the most widespread type of TCAM among the study population in Lesotho. Prospective studies on TCAM usage are necessary to inform proper practice and safety in Lesotho.
Structure, Stability, and Electronic Feature Analyses of Substrates (Methyl Orange and Vanadium Oxide)-Surfactant (Triton X-100) Complex: A Computational Insight
Authors: Vemuri Rama Satya Sarveswara Srikanth , Pandey Sarvesh Kumar , Khanal Govinda Prasad 
Published: March 2022

Aims:The objective of the present work is to understand the structural stability (i.e., H-bonding and other weak noncovalent interactions) and electronic features of new model substrates, such as methyl orange (MO), vanadium oxide (V), surfactants as Triton-X100 (TX-100), and their allied substrate-surfactant model complexes (MO-V, MO-TX100, V-TX100, and (MO-V)-X100) with the deployment of density functional theory (DFT) method followed by electronic structure calculations and quantum theory of atoms in molecules (QTAIM) approaches.Background:Significant interactions appear to play a major role in reducing the energy gap between the model substrates Methyl Orange (MO)/Vanadium Oxide (V)/MO-V) and surfactant/catalyst Tri-ton-X100 (TX-100) and enhancing the catalytic behaviour of the surfactant/catalyst TX-100.Objective:The main objective of the present report is to conduct computational experiments on the designing, characterization, structure, stability, and electronic feature analyses of substrates-surfac-tant model complexes constituted from Methyl Orange (MO), Vanadium Oxide (V), Triton-X100 (TX-100) units which could indeed help in synthesizing novel materials as a catalyst, controlling the reaction path by tuning such interesting interactions between a catalyst/surfactant and substrate.Methods of Computational Calculations:The quantum chemical calculations have been performed using Gaussian 09 electronic structure calculations program. B3LYP exchange-correlation functional in conjunction with 6-31G(d,p) basis set has been employed along with the incorporation of the ef-fective core potential (ECP) based basis set for vanadium ‘V’ atom.Results:In the present report, the computational experiments have been conducted to probe the struc-tural, stability, and electronic features of four substrates-surfactant model complexes (SSMC) [MO-V, MO-TX-100, V-TX-100, and (MO-V)-TX-100] acquired from the substrates MO and V or the combination of both as MO-V and surfactant/catalyst TX-100. The HOMO-LUMO energy gap of the (MO-V)-TX-100 SSMC complex (0.679 eV) is found to be the lowest among all [MO-V (3.691 eV), MO-TX-100 (3.321 eV), and V-TX-100 (3.125 eV)] SSMCs, which appears mainly due to the presence of surfactant/catalyst (TX-100), thus showing its high reactivity/catalytic behaviour.Conclusion:The calculated binding energy, change in Gibbs free energy, natural charges, and the QTAIM based topological parameters show the most favourable stabilization (H-bonding and non-covalent interactions, including metal/non-metal bonding) and interactions in the (MO-V)-TX-100 SSMC, indicating the presence of the TX-100 surfactant.
FIRM VALUE DETERMINATION WITH INFLATION AND EXCHANGE RATE AS A MODERATING VARIABLE (Study on the Manufacturing Industry Recorded in Indonesian Sharia Stock Index)
Authors: Soekapdjo Soeharjoto , * Miyasto , Mariyanti Tatik 
Published: March 2022

Purpose - Aims of this research are to determine the factors that influence the firm value of the manufacturing industry listed on the Indonesia Sharia Stock Index.

Design/methodology/approach - Used panel data regression method from 2013-2018, then obtained 30 manufacturing industry companies after purposive sampling. Syariah stock investors who rationally and religiously behave are accommodated in the variables used. The dependent variable is firm value and the independent variable are return on equity, current ratio, debt to equity ratio, total assets turn over, Islamic social reporting, with the exchange rate and inflation as the moderating variable.

Finding - Results show that return on equity with inflation as a moderating variable has a positive effect on firm value. Islamic social reporting has a positive effect on firm value. Debt to equity ratio with the exchange rate as a moderating variable has a negative effect on firm value. The current ratio and total assets turnover are not significant to firm value.

Practical Implication - To increase the firm value, it is necessary to improve human resources and the application of environmentally friendly technology, planning in production and expansion, transparency and application of sharia principles, professional and fair managers.

Originality/value - This study combines the company’s financial ratios, Islamic social reporting, and macroeconomic conditions that are beyond management control. Tobins’ Q is used to the corporate values approach. All of these, reflect that firm value is influenced by company performance, society, and government.

Keywords - Firm Value, Financial Ratio, Islamic Social Reporting, Sharia Enterprise Theory, Macroeconomics, Indonesia Sharia Stock Index
DISTRIBUTION OF CREDIT FOR MICRO, SMALL, AND MEDIUM ENTERPRISES OF MANDIRI BANK SINAKMA MARKET JAYAWIJAYA
Authors: Ali Muhammad , Haryati Tati , * Aprilia 
Published: March 2022

AbstractThe purpose of KUR is to increase access to finance for Small and Medium Enterprises (UKM) to financial institutions with a guarantee scheme through the People's Business Credit (KUR). The KUR guarantee is provided in order to increase UMKM access to sources of financing in order to encourage national economic growth. Bank Mandiri is one of the State-Owned Enterprises (BUMN) that was established to assist UMKM players in realizing their business and maintaining business continuity. The results showed that with the existence of a program from the government through the distribution of People's Business Credit which was channeled through PT. Bank Mandiri KCP MMU Wamena Pasar Sinakma for the welfare of Micro, Small, and Medium Enterprises (UMKMÂ Keywords: People's Business Credit, UMKM
ANALYSIS OF ACCEPTANCE OF ACCOUNTING INFORMATION SYSTEM IMPLEMENTATION BASED ON ELECTRONIC PAYMENT USING THE UTAUT MODEL
Authors: Aviyanti Richo Diana , Saraswati Erwin , Prastiwi Arum 
Published: March 2022

Purpose — This study aims to examine and analyze the effect of performance expectancy, effort expectancy, social influences, and facilitating conditions on the actual use of electronic payment-based accounting information systems.
Design/methodology/approach — Data obtained through online questionnaires filled out by 247 active users of electronic payment systems. The analysis method used is a Structural Equation Modeling/SEM with a Partial Least Square/PLS test tool.
Findings — Empirical evidence shows that performance expectancy, effort expectancy, social influences, and facilitating conditions significantly affect electronic payment systems' actual use.
Practical implications — Electronic payment platforms are recommended to provide an electronic payment application system that can be used easily and usefully. The platform can use these results as a reference regarding customer behavior in using an electronic payment-based accounting record system
Originality/value — This study uses UTAUT which is modeled directly on actual use.
Keywords — Accounting; System; Electronic Payments; UTAUT; and Actual Use.
Paper type — Positive Paradigm Research Paper