bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can higher SO2 emission tax rates reduce PM2.5 concentration in China's cities? A quasi-natural experiment from the perspective of spatial spillover
Authors: Wang Kaifeng , Liu Yu , Wang Shaochen , Li Chengpeng 
Published: October 2022

Abstract
In this paper, the adoption of SO2 emission tax rates higher than the legal minimum standard is regarded as a noteworthy policy reform in China's cities (quasi-natural experiment), and a spatial Difference-in-Differences (Spatial-DID) model is constructed to test the direct effects (local effects) and indirect effects (spatial spillover effects) of SO2 emission tax policy reform on PM2.5 concentrations in the atmosphere of 285 China's cities. The estimation and calculation results of the Spatial-DID model show that the SO2 emission tax policy reform can significantly suppress local PM2.5 pollution and significantly promote PM2.5 pollution in surrounding areas. The results of heterogeneity analysis show that the SO2 emission tax policy reform can produce a relatively more beneficial spatial spillover effect in cities in the eastern region, higher administrative level cities, and pollutant emission rights trade pilot cities. The results of the mediation effect analysis show that the higher SO2 emission tax rate can aggravate the surrounding PM2.5 pollution by promoting the aggregation level of industrial production factors and the industrial SO2 emission intensity in the surrounding areas, which can support the existence of the pollution heaven effect.
Gold Sea Urchins-shaped nanoparticles: synthesis and characterization of energy transducer candidates
Authors: Candreva Angela , Morrone Elena , Deda Massimo La 
Published: October 2022

Abstract
Gold nanospheres and gold nanorods of different sizes have been synthesized by a seed-mediated growth approach. They have been characterized by TEM, UV-Vis spectroscopy, and the photothermal effect of spheres have been tested. By adding a dimethylformamide solution of polyvinylpyrrolidone and tetrachloroauric acid to the nanoparticles, an interesting nano-shape, composed of a quasi-spherical core with copious spikes (core size ranging from 50 to 100 nm and spikes from 15 to 50 nm) - just remembering the sea urchins - has been obtained. Depending on the starting sample of nanoparticles (spheres or rods), the size of the core changes, while there are slight variations of the spikes. Plasmonic features in the visible to IR range of the electromagnetic spectrum have been recorded, and it was observed an increase of the photothermal effect by increasing the nanourchins core dimensions.
Osteoclastogenic-inducing effects of fluoroquinolones on human osteoclast and osteoblast co-cultures
Authors: Costa-Rodrigues João 
Published: October 2022

Abstract
Fluoroquinolones (FQs) are a broad-spectrum class of antibiotics that may cause some secondary effects in bone tissue, such as delayed fracture healing or osteoarthritis. The aim of this work was to evaluate the effects of five different FQs (ofloxacin, norfloxacin, ciprofloxacin, levofloxacin and moxifloxacin) in osteoclastogenesis, using co-cultures of human osteoclasts and osteoblasts as an in vitro model. It was observed that all FQs, except levofloxacin, promoted an increase in osteoclast formation, gene expression and calcium phosphate resorbing ability, in a dose-dependent manner. MEK and NFkB signaling pathways were involved in cell response, as well as PGE2 production. The observed increase in osteoclastogenesis may be involved in the deleterious effects that FQs may cause in bone tissue.
FDD: The Data Pipeline for Steel Defect Detectors
Authors: Akhyar Fityanul , Liu Ying , Hsu Chao-Yung , Shih Timothy K. , Lin Chih-Yang 
Published: October 2022

Abstract
Surface defects are a common issue that affects product quality in the industrial manufacturing process. Many companies put a lot of effort into developing automated inspection systems to handle this issue. In this work, we propose a novel deep learning-based surface defect inspection system called the forceful steel defect detector (FDD), especially for steel surface defect detection. Our model adopts the state-of-the-art cascade R-CNN as the baseline architecture, and improves it with the deformable convolution and the deformable RoI pooling to adapt to the geometric shape of defects. Besides, our model adopts the guided anchoring region proposal to generate bounding boxes with higher accuracies. Moreover, to enrich the point-of-view of input images, we propose the random scaling and the ultimate scaling techniques in the training and inference process, respectively. The experimental studies on the Severstal steel dataset, NEU steel dataset, and DAGM dataset demonstrate that our proposed model effectively improved the detection accuracy in terms of the average recall (AR) and the mean average precision (mAP) compared to state-of-the-art defect detection methods. We expect our innovation to accelerate the automation of the industrial manufacturing process by increasing productivity and by sustaining high product qualities.
Multifunctional polysaccharide structure as green adsorbent for chlorophenols removal from aqueous solutions: experimental and modeling approaches
Authors: Ferrah Nacer , Merghache Djamila , Chabane Mustapha , Derdour Abdessamed , Mansour Riad , Nouri Tayeb , Cheikh Sid Ahmed , Zerriahen El Housseyn 
Published: October 2022

Abstract
A trifunctional polysaccharide structure based on a biodegradable matrix, Chitosan/Alginate-PolyEthylene-Imine-Phenyl-Phosphonamidic Acid (CHIT/ALG-PEIPPAA) was synthesis via a condensation reaction, using glutaraldehyde as cross linking agent. The aim of this research work is to investigate the chlorophenols adsorption in the batch process from an aqueous medium. The influence of several parameters like pH, time reaction, initial concentration, and ionic strength was followed carefully in this study. Scanning electron microscopy (SEM) micrographs show a heterogeneous morphology with different particle sizes of agglomerates around a few micrometers, and irregular particles shape. The FTIR spectrum and Zeta potential characterization confirms the presence of several hydrophilic groups and a high positive charge around 31.4 mV for CHIT/ALG-PEIPPAA surface adsorbent. The optimum pH solution for chlorophenols removal was reached at an initial pH of around 4.4. The maximal adsorption capacity was found to be 118 mg.g− 1, and 249 mg.g− 1 under optimum conditions for 4-chlorophenols and 2–4 chlorophenols respectively. The kinetic modeling followed the pseudo-second-order rate expression for both chlorophenols molecules. Thermodynamics data leads to an exothermic and spontaneous adsorption process (∆H = − 6.98KJ.mol− 1; ∆H = − 2.74KJ.mol− 1), respectively for 4-chlorophenols and 2–4 chlorophenols. The regeneration process of CHIT/ALG-PEIPPAA is more favorable in the presence of hydrochloride acid (2.0 mol.L− 1), up to 78%, and 91% of desorption yield for 4-chlorophenols and 2–4 chlorophenols, respectively.
Hyperreflective Material in Patients with Nonneovascular Pachychoroid Disease
Authors: Maruyama-Inoue Maiko , Yanagi Yasuo , Mohamed Shaheeda , Inoue Tatsuya , Kitajima Yoko , Ikeda Shoko , Kadonosono Kazuaki 
Published: October 2022

Abstract
Purpose: This study aimed to report eleven cases of nonneovascular pachychoroid disease with hyperreflective material (HRM) that occurred in Japanese patients.
Methods: A retrospective review of data from eleven patients who had nonneovascular retinal pigment epithelium (RPE) protrusion with HRM in the neurosensory retina between March 2017 and June 2022 was conducted. Clinical examination, color fundus photography, fluorescein angiography, spectral-domain optical coherence tomography (SD-OCT), and OCT angiography data were analyzed for a consecutive series of these eyes. Main Outcome Measures were patient characteristics, changes in SD-OCT findings, and symptom outcomes.
Results:All cases had RPE protrusion and HRM with dilated choroidal veins, which were characteristic of pachychoroid disease. However, none of the cases had macular neovascularization (MNV). In 9 eyes (81.8%), HRM improved spontaneously without intervention and resulted in alterations in RPE, referred to as pachychoroid pigment epitheliopathy (PPE) or focal choroidal excavation (FCE). In these cases, symptoms such as metamorphopsia and distortion improved without treatment. In the remaining two cases (18.2%), HRM still persisted during the follow-up period.
Conclusion: There are some cases of nonneovascular pachychoroid disorder with HRM, which might be a new entity of pachychoroid spectrum disease or an early stage of PPE or FCE. These cases should not be misdiagnosed as MNV, and careful observation is necessary.
Performance of a novel 8-color flow cytometry panel in the detection of minimal residual disease assessment of chronic lymphocytic leukemia
Authors: Chen Xiao , Zhao Sishu , Shi Yu , Zhang Ninghan , Guo Zhen , Qiao Chun , Jin Huimin , Zhu Liying , Zhu Huayuan , Li Jianyong , Wu Yujie 
Published: October 2022

Abstract
Background
The status of minimal residual disease (MRD) has been established as an important prognostic indicator in chronic lymphocytic leukemia (CLL).
Methods
Owing to the requirements of high accuracy, reproducibility and comparability of MRD, this study investigated the performance of a flow cytometric approach (CD45-ROR1 panel) in the MRD detection of CLL patients, with European Research Initiative on CLL (ERIC) 8-color panel as the “gold standard”.
Results
The sensitivity, specificity and concordance rate of CD45-ROR1 panel in the MRD assessment of CLL were 100% (87/87), 88.5% (23/26) and 97.3% (110/113), respectively. Two of the 3 non-consistent samples were further verified by the next-generation sequencing. In addition, the MRD results obtained from the CD45-ROR1 panel were positively associated with the ERIC 8-color results for MRD assessment (R = 0.98, p < 0.0001). MRD detection at low levels (≤ 1.0%) demonstrated a smaller difference between the two methods (bias, -0.11; 95% CI, -0.90-0.68) as compared with that at high levels (>0.1%). For the reproducibility assessment, the bias was smaller at three datapoints in the CD45-ROR1 panel as compared with that of the ERIC 8-color panel. Moreover, MRD level detected using the CD45-ROR1 panel for the same samples between different laboratories showed a strong statistical correlation (R = 0.99, p < 0.0001) with a trivial inter-laboratory variation (bias, 0.135; 95% CI, -0.439-0.709). Interesingly, the MRD level detected in the lymph nodes samples were significantly higher than that of the peripheral blood and bone marrow samples (p = 0.029).
Conclusions
Collectively, this study demonstrates that the CD45-ROR1 panel is a reliable method for the MRD assessment of CLL, with higher sensitivity, reproducibility, and reliability.
CircTNFRSF19 Facilitates Triple Negative Breast Cancer Cell Growth by Regulating N6-methyladenosine Modification of B3GNT5
Authors: Li Zhi , Zhao Ruipeng 
Published: October 2022

Abstract
Objectives
Triple negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer. Accumulated evidence has shown that circular RNAs (circRNAs) could impact proliferation and apoptosis of TNBC cells. However, the function of circTNFRSF19 has not been discussed in TNBC so far. This study intended to explore the role of circTNFRSF19 in TNBC cell growth and its relevant molecular mechanism.
Methods
RT-qPCR and western blot assays were conducted to detect target gene expression. Functional assays were carried out to access the influence of circTNFRSF19 and B3GNT5 on TNBC cell proliferation and apoptosis. Mechanism assays were performed to verify the underlying relationship of circTNFRSF19/IGF2BP2/B3GNT5 axis in TNBC cells.
Results
CircTNFRSF19 demonstrated a higher expression in TNBC tissues and cells. The data also showed that circTNFRSF19 could promote TNBC cell proliferation, while inhibiting apoptosis. Mechanically, it was found that circTNFRSF19 recruited IGF2BP2 to regulate B3GNT5 mRNA expression in TNBC cells, and IGF2BP2 was verified to stabilize B3GNT5 mRNA via m6A modification in TNBC cells. B3GNT5 was also proved to facilitate TNBC cell proliferation and inhibit apoptosis.
Conclusion
CircTNFRSF19 is uncovered to facilitate TNBC cell growth by recruiting IGF2BP2 to stabilize B3GNT5 mRNA expression.
Involvement of octopamine in conditioned visual flight orientation in honeybees
Authors: Kobayashi Norihiro , Hasegawa Yuji , Okada Ryuichi , Sakura Midori 
Published: October 2022

Abstract
Visual orientation learning of a tethered flying bee was investigated using a flight simulator with a novel protocol using which orientation preference tests were performed before and after classical conditioning was applied. Either a blue or a green rectangle (conditioned stimulus, CS) was associated with 30% sucrose solution (unconditioned stimulus, US), whereas the other was not paired with US. Bees were tested in a closed-looped flight simulator 5 min after ten pairing presentations of US and CS. Conditioned bees preferentially oriented to the CS compared to the other color. This increase in the preference for CS was maintained for 24 h, indicating that long-term memory was established by this procedure. Because the total flight time was not altered by the conditioning, conditioning did not enhance orientation activity itself but increased the relative time for orientation to CS. When 0.4 or 4 mM epinastine (an antagonist of the octopamine receptor) was injected into the bee’s head 30 min prior to the experiment, both short- and long-term memory formation were significantly impaired, strongly suggesting that octopamine, which is crucial for appetitive olfactory learning in insects, is also involved in visual orientation learning.
Eltrombopag inhibits metastasis via targeting HuR protein in breast carcinoma
Authors: Chen Yao , Zhang Rui , Yang Liuqing , Zhang Pei , Wang Feiyun , Zhu Yuying , Zhang Jiange 
Published: October 2022

Abstract
Background
Metastatic of breast cancer is one of the leading causes of cancer-related death. HuR is an mRNA binding protein, which could regulate mRNA stability of multiple cancer-related genes, including metastasis-related genes Snail, Cox-2 and Vegf-c. Eltrombopag is a small molecule TPO-R agonist which has been demonstrated to inhibit tumor growth by targeting HuR protein. However, the effect and mechanisms of eltrombopag in breast cancer metastasis has not been fully investigated. This study aimed to investigated the role of eltrombopag in breast cancer metastasis.
Methods
Activity of eltrombopag on molecular level was detected with Electrophoretic mobility shift assay (EMSA) and Fluorescence polarization (FP). Scratch wound assay and transwell assays were carried out to verified cell migration and invasion. Moreover, mechanism of HuR-dependent inhibition of breast cancer metastasis was identified with qRT-PCR, mRNA stability assay, RNA immunoprecipitation analysis and luciferase assays. The effect of anti-tumor metastasis in vivo was investigated by in vivo imaging system.
Results
We found that HuR-AREs complexes were disrupted by eltrombopag at molecular levels. Functionally, eltrombopag suppressed 4T1 cell migration and invasion, inhibited macrophage-mediated lymphangiogenesis in vitro. Mechanistically, eltrombopag was verified to inhibit the expression of Snail, Cox-2, Vegf-c in 4T1 cells and Vegf-c in RAW264.7 cells through targeting HuR. Finally, eltrombopag exerts inhibitory effects in lung metastasis and lymph node metastasis in vivo.
Conclusions
Eltrombopag display anti-metastasis activity in breast cancer with HuR dependent manner, which may provide a novel application of eltrombopag and imply the multiple effects of HuR inhibitors in cancer therapy.
Nutritional Assessment Among khalwa students at El-Mergania and Khogali Abo Al-Jaz khalawi, Khartoum state, Sudan 2021.
Authors: Gasoma Elmuhtadi , Al-Sir Ali , Mohammed Samah , Tarig Gotof 
Published: October 2022

Abstract
Background : Nutritional assessment is the systematic process of collecting and interpreting information in order to make decisions about the nature and cause of nutrition related health issues that affect an individual. The process promotes consistent quality of practice; is user friendly; and allows effective monitoring of patients. Khalawi are traditional religious schools, they are very popular in Sudan. The Khalawi (Quran Schools) and Maseeds (Mosques) played and are still playing great roles in designing the consciences of the people of Sudan. They were the available institutions where people learnt teachings of Islam as well as the formal education. Most of them were established by Shiekhs and well-wishers. That distinguish those institutions is that most of them were established in remote and isolated spots of land where no one wanted to live. khalwa students are considered to be at high risk of nutritional problems due to several factors the most important of them are poor self-hygiene, high contamination area and the type of food which mainly depend on sorghum .
Methods : Study population was 150 students ranged from 8 – 18 years old, lived at least for one year in the khalwa. Informed consent was obtained. The study was In two stages and used complementary qualitative and quantitative methods. Stage one involved in-depth, face-to-face, interview with key informants. Stage two involved assessment of nutritional status of students using interview questionnaire and anthropometric measurement.
Results : we found that most of them aged from 13-15 years old, with few less or more. They eat together in groups (4-7 students) or even more which lack organization and specific categorization according to age or any other parameters. 38 students those represent substantial percentage (25 %) are underweight, which is exactly the quarter of the total sample size which indeed a devastating matter of fact, especially these khalawi are located at the center of the capital city.
Conclusion : The lack of informations , researches and knowledge regarding those particular group of people whom are at increasing risk of malnutrition necessitate the conduction of this study to work as a corner-stone for further researches later on which all directed toward improving and maintaining a proper studying and living environment .
Building a mathematical model to prevent hydrate formation in gas pipelines
Authors: Gurbanov Abdulaga , Sardarova Ijabika , Damirova Javida 
Published: October 2022

Development of mathematical models of laminar gas flow in certainty and uncertainty conditions were considered. All factors that influence to character of flow of gas in pipeline and conditions of arising of hydrate inside of pipeline wall are analyzed. Results of analyze were used for development mathematical model of gas flow in pipeline that allow to calculate main parameters of hydrate deposition process. Model of gas flow consist of three non-linear differential equations that can be solved by exist soft wares. Two and three-dimension characteristic obtained, that describe of quantity of hydrate deposited at given process depending on time.
Besides, the effectiveness of using DELPHI 7 software to determine the preparation of gas for transportation and the hydrates formed during transportation and its prevention based on the results of the application software was discussed. As a result, the change in cross-sectional area of the pipeline of hydrates formed on the inner surface of the pipeline is shown in 3D. Hydrate formation and elimination are visually represented by graphs. The results of theoretical and practical studies of changes in the inner surface of the pipeline depending on temperature and pressure have been identified. All this was investigated during quasi-stationary gas flow in the pipelines and the results were obtained.
The assumes regarding calculation of parameters of gas flow were determined and necessary recommendations for applying of developed model in different conditions with taking account of temperature and pressure variation and depending on time of hydrate deposition were presented. The diagram of gas-hydrate separation boundary considered for detailed analysis of process
Assessment and predictors of blood glucose levels in hypertensives attending a secondary health centre: relationship with physical activity and diet quality
Authors: Azeez Ismaheel Aderogba , Fasanmade Adesoji Adedipe , Ilori Temitope 
Published: October 2022

The aim: this study aims to assess the prevalence of hyperglycaemia, the association between diet quality, physical exercise and blood glucose levels among hypertensives attending a secondary health centre in Nigeria. There is a paucity of data concerning these issues and the study would contribute positively to future management of the patients.
Methods: the study was a cross-sectional study of 354 hypertensives that was conducted at the State Hospital, Oyo, Nigeria. The systematic sampling technique was used to recruit patients, and the data were analysed using SPSS software version 23. Linear regression was done to determine the predictors of hyperglycaemia, and logistic regression was done to determine the predictors of diet quality.
Results: the mean age of the respondents was 52.60(SD±8.26) years. The prevalence of undiagnosed diabetes in this cohort was 19.60 %. The association of glycated haemoglobin (HbAic) with High Density Lipoprotein (HDL) was negative, weak in strength and statistically significant (p-value=0.034). For every 1 unit decrease in High Density Lipoprotein (HDL), there was a statistically significant increase in HbAic by about 0.383 units (95 % C.I equals -0.737 to -0.029, p-value=0.034). For every 1 unit increase in total Cholesterol, there was a significant increase in HbAic by about 0.158 units (95 % CI equals 0.007 to 0.308, p-value=0.04). Age group <45 years were about 2 times less likely to have good diet quality than those of 55 years and above (OR=0.502; 95 % CI=0.270 – 0.932, p-value=0.029).
Conclusions: the study has assisted to characterise this population of hypertensives in terms of serum glucose levels. The prevalence of hyperglycaemia was high among these hypertensives. The predictors of hyperglycaemia were HDL and Cholesterol. Also, the predictor of good diet quality was the age of the respondents