bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wine Geographical Indications and Product Specifications: A Case of Prosecco Quality and Characteristics?
Authors: Spagnolo Lisa , Davison Mark 
Published: April 2022

Abstract
Article 22 of the Agreement on Trade-Related Aspects of Intellectual Property Rights defines Geographical Indications (GI). However, GI claims are increasingly contentious. Given the significance of trade barriers which can arise from unjustified GI claims, the article argues that legitimacy of GI claims must turn on whether objective evidence exists to the effect that Article 22(1) criteria are met. This article tests certain elements of the EU ‘Prosecco’ GI claim – that its qualities and characteristics are essentially attributable to the relevant location – against Italian production specifications to determine whether they provide evidentiary justification for the GI claim. This reveals evidence of absence of consistent qualities or characteristics in ‘Prosecco’ wine. The article additionally examines evidence explaining why this is so. The consequence of this conclusion is that the EU ‘Prosecco’ GI claim must rest solely upon the concept of ‘reputation’ for its legitimacy. Moreover, the approach taken by this article can be utilized to test the legitimacy of any GI claim so far as it relates to quality and characteristics.
The Geographic Indication Prosecco Battle Between Italy and Australia: Some Lessons from the History and Geography of the Most Famous Italian Wine
Authors: Bonadio Enrico , Contardi Magali 
Published: April 2022

Abstract
This article seeks to contribute to the debate around the legality of the Prosecco geographical indication (GI). The article’s main point is to demonstrate that the term Prosecco does satisfy the conditions laid down in Article 22 of the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS), and that its protection as a GI in both the European Union (EU) and other countries does not run counter to TRIPS. Through a review of the relevant literature, the article shows that this term has been used for many centuries in the northeastern part of the Italian peninsula to refer to a high-quality wine, including in the territory around the village of Prosecco in the Friuli Venezia Giulia region of Italy. This suggests a strong link between that area and the quality and reputation of the famous Italian sparkling wine and strengthens the EU and Italy’s claims for the protection of the term Prosecco as GI in both the EU and other countries that sign trade agreements with the EU.
The Compatibility of the European Union’s Geographical Indications Regulations for Wines with the World Trade Organization Agreement on Technical Barriers to Trade
Authors: Henckels Caroline 
Published: April 2022

Abstract
The Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS Agreement) sets a floor but not a ceiling for intellectual property protection. Examining the EU’s geographical indications regime for wines, this article considers the question of when a World Trade Organization member’s measures taken to implement the TRIPS Agreement might contravene the member’s obligations under the Agreement on Technical Barriers to Trade (TBT Agreement). A technical regulation apparently permitted by the TRIPS Agreement may be inconsistent with the TBT Agreement where it does not in good faith pursue a legitimate objective or where it is incongruent with or poorly calibrated to its objective. In particular, the compatibility with the TBT Agreement of EU regulations that prohibit the labelling of wines with the relevant grape variety name where the variety name ‘contains or consists of’, ‘evokes’ or ‘forms an integral part of’ a GI is open to doubt.
Mapping an Observation-Based Global Solar Irradiance Climatology across the Conterminous United States
Authors: Rupp David E. , Daly Christopher , Doggett Matthew K. , Smith Joseph I. , Steinberg Ben 
Published: April 2022

Abstract
The exponential growth in solar radiation measuring stations across the conterminous United States permits the generation of gridded solar irradiance data that capture the spatiotemporal variability of solar irradiance far more accurately than was previously possible from ground-based observations. Taking advantage of these observations, we generated a 30-yr climatology (1991–2020) of mean monthly global irradiance at a resolution of 30 arc s (∼800 m) on both a horizontal surface and a sloped ground surface. This paper describes the methods used to generate the gridded data, which include extensive quality control of station data, spatial interpolation of effective cloud transmittance using the “PRISM” method, and simulation of the effects of elevation, shading, and reflection from nearby terrain on solar irradiance. A comparison of the new dataset with several other solar radiation products reveals some spatial features in solar radiation that are either lacking or underresolved in some or all of the other datasets. Examples of these features include strong gradients near foggy coastlines and along mountain ranges where there is persistent orographically driven cloud formation. The workflow developed to create the long-term means will be used as a template for generating time series of monthly and daily solar radiation grids up to the present.
Aligning Trends in Climatic Parameters and Nomads’ Indigenous Knowledge about Climate Change in Central Iran (Case Study: Semirom Town)
Authors: Saboohi Razieh , Barani Hossein , Khodagholi Morteza , Sarvestani Ahmad Abedi , Tahmasebi Asghar , Feuer Hart Nadav 
Published: April 2022

Abstract
Nomadic pastoral communities are considered some of the most vulnerable to climate change. While Indigenous knowledge can play an effective role in mitigating or responding to some impacts of climate change, the extent of their capacity to adapt their livestock and rangeland management is under question. This research aims to assess the scope and applicability of climate change–related knowledge acquired in the management of summer rangeland, with a case study in Semirom, Isfahan Province, Iran. To do so, objective weather conditions (precipitation, minimum temperatures, and maximum temperatures) were evaluated using the Mann–Kendall nonparametric test and compared with subjective evaluations by nomad community members. Specifically, the study targeted a community of 7700 members of the Qashqai, a conglomeration of nomadic tribes in Iran. Their understanding of the weather was evaluated using focus groups and self-administered questionnaires, with a descriptive approach to data analysis. The findings of the climatic investigation revealed a possible shift in the climate in the study area, particularly in winter and autumn. The findings of subjective evaluation showed similar changes in wind, precipitation, and temperature to be the main characteristics of climate change in the region, with about 90% of informants directly citing decreasing precipitation and increasing temperature and wind speeds. The community evaluation also highlighted some adaptations to climate change, such as delays in beginning the seasonal migration, increased reliance on concrete homes, reservoir construction, decreasing livestock yields, and increasing diversification of resources to feed livestock. Understanding the perceptions of nomadic pastoralists, their meteorological basis, and ongoing climate adaptations can facilitate governmental planning.
Platelet-targeted thrombolysis for treatment of acute ischemic stroke
Authors: Palazzolo Jason S. , Ale Anukreity , Ho Heidi , Jagdale Shweta , Broughton Brad R. S. , Medcalf Robert L. , Wright David K. , Alt Karen , Hagemeyer Christoph E. , Niego Be’eri 
Published: April 2022

AbstractThrombolysis with tissue-type plasminogen activator (tPA) remains the main treatment for acute ischemic stroke. Nevertheless, tPA intervention is limited by a short therapeutic window, low recanalization rates, and a risk of intracranial hemorrhage (ICH), highlighting the clinical demand for improved thrombolytic drugs. We examined a novel thrombolytic agent termed “SCE5-scuPA,” comprising a single-chain urokinase plasminogen activator (scuPA) fused with a single-chain antibody (SCE5) that targets the activated glycoprotein IIb/IIIa platelet receptor, for its effects in experimental stroke. SCE5-scuPA was first tested in a whole blood clot degradation assay to show the benefit of platelet-targeted thrombolysis. The tail bleeding time, blood clearance, and biodistribution were then determined to inform the use of SCE5-scuPA in mouse models of photothrombotic stroke and middle cerebral artery occlusion against tenecteplase. The impacts of SCE5-scuPA on motor function, ICH, blood–brain barrier (BBB) integrity, and immunosuppression were evaluated. Infarct size was measured by computed tomography imaging and magnetic resonance imaging. SCE5-scuPA enhanced clot degradation ex vivo compared with its nonplatelet-targeting control. The maximal SCE5-scuPA dose that maintained hemostasis and a rapid blood clearance was determined. SCE5-scuPA administration both before and 2 hours after photothrombotic stroke reduced the infarct volume. SCE5-scuPA also improved neurologic deficit, decreased intracerebral blood deposits, preserved the BBB, and alleviated immunosuppression poststroke. In middle cerebral artery occlusion, SCE5-scuPA did not worsen stroke outcomes or cause ICH, and it protected the BBB. Our findings support the ongoing development of platelet-targeted thrombolysis with SCE5-scuPA as a novel emergency treatment for acute ischemic stroke with a promising safety profile.
Effects of 3 months of detraining following cardiac rehabilitation in patients with atrial fibrillation
Authors: Borland Maria , Bergfeldt Lennart , Cider Åsa , Rosenkvist Agneta , Jakobsson Marika , Olsson Kristin , Lundwall Adam , Andersson Lars , Nordeman Lena 
Published: April 2022

Abstract
Background
Atrial fibrillation negatively impacts physical fitness and health-related quality of life. We recently showed that 3 months of physiotherapist-led exercise-based cardiac rehabilitation improves physical fitness and muscle function in elderly patients with permanent atrial fibrillation and concomitant diseases. Little is, however, known about the consequences for physical fitness, physical activity level, and health-related quality of life after ending the rehabilitation period.

Methods
Prospective 3 months follow-up study of 38 patients out of 40 eligible (10 women) who, as part of a randomized controlled trial, had completed a 3 months physiotherapist-led cardiac rehabilitation resulting in improved physical fitness,. In the current study, the participants were instructed to refrain from exercise for 3 months after completion of the rehabilitation period. Primary outcome measure was physical fitness measured as highest achieved workload using an exercise tolerance test. Secondary outcome measures were muscle function (muscle endurance tests), physical activity level (questionnaire and accelerometer), and health-related quality of life, (Short Form-36), as in the preceding intervention study. We used the Wilcoxon Signed Rank test to analyse differences between the end of rehabilitation and at follow-up. The effect size was determined using Cohen’s d .

Results
Exercise capacity and exercise time significantly decresead between end of rehabilitation and at follow-up (p < .0001 for both). A significant reduction in shoulder flexion repetitions (p = .006) was observed as well as reduced health-related quality of life in the Short Form-36 dimensions Physical Function (p = .042), Mental Health (p = .030), and Mental Component Score (p = .035). There were, however, no changes regarding objective and subjective physical activity measurements.

Conclusion
In older patients with permanent atrial fibrillation, previously achieved improvements from physiotherapist-led exercise-based cardiac rehabilitation in physical fitness and muscle function were lost, and health-related quality of life was impaired after ending the rehabilitation period. A strategy for conserving improvements after a rehabilitation period is essential.
Effects of situated learning and clarification of misconceptions on contextual reasoning about natural selection
Authors: Aptyka Helena , Fiedler Daniela , Großschedl Jörg 
Published: April 2022

Abstract
Background
Natural selection is a core principle of evolution. Understanding natural selection enables students to think about the evolution and the variability of life. Despite its great importance, understanding natural selection is challenging for students. This is evident in the phenomenon of contextual reasoning, showing that students can often explain natural selection in one context (e.g., trait gain) but not in another (e.g., trait loss). The study pursues the following aims: First, to examine the link between contextual reasoning and situated learning. Second, to explore whether different instructional strategies differ in their associated cognitive load. Third, to investigate whether clarifying common misconceptions about natural selection (no vs. yes) is an effective strategy to regular instructions when aiming to increase key concepts and reduce misconceptions. Fourth, to exploratively examine the effectiveness of different instructional strategies.

Method
In a 2 × 2 factorial intervention study with a total of N = 373 secondary school students, we varied the instructional material of a 90-min intervention in terms of the evolutionary context (trait gain vs. trait loss) and the availability of additional support in the form of a clarification of misconceptions (no vs. yes). We measured students’ cognitive load immediately after instruction and assessed their ability to reason about natural selection (i.e., use of key concepts and misconceptions) later.

Results
We documented low knowledge about evolution in the pre-test and persisting misconceptions in the post-test. The results showed that the intervention context of trait loss elicited a higher intrinsic and extraneous cognitive load than trait gain. Moreover, when the clarification of misconceptions is analyzed in connection to the intervention context, it reveals a potential for reducing misconceptions in some contexts. Students who have learned in trait gain contexts with a clarification used significantly fewer misconceptions in later reasoning than students who learned in trait gain contexts without a clarification of misconceptions.

Conclusion
Our study creates new insights into learning about natural selection by outlining the complex interplay between situated learning, cognitive load, clarification of misconceptions, and contextual reasoning. Additionally, it advises researchers and educators on potential instructional strategies.
Analgesic effects of sufentanil in combination with flurbiprofen axetil and dexmedetomidine after open gastrointestinal tumor surgery: a retrospective study
Authors: Liu Fei , Li Ting-Ting , Yin Lu , Huang Jin , Chen Yan-Jun , Xiong Liu-Lin , Wang Ting-Hua 
Published: April 2022

Abstract
Background
To investigated the effects of sufentanil in combination with flurbiprofen axetil and dexmedetomidine for patient-controlled intravenous analgesia (PCIA) on patients after open gastrointestinal tumor surgery, and compared this combination with traditional PCIA with pure opioids or epidural analgesia (PCEA).

Methods
Patients (n = 640) who underwent open gastrointestinal tumor surgery and received patient-controlled analgesia (PCA) were included. According to the type of PCA, patients were assigned to three groups: MPCIA (PCIA with sufentanil, flurbiprofen axetil, dexmedetomidine and metoclopramide), OPCIA (PCIA with sufentanil, tramadol and metoclopramide) and PCEA group (PCEA with sufentanil and ropivacaine). The characteristics of patients, intraoperative use of analgesics, postoperative visual analogue scale (VAS), postoperative adverse reactions and postoperative recovery were collected. The primary outcome was postoperative VAS score. One-way ANOVA, Kruskal-Wallis H test, Fisher exact probability method, and binary logistic regression analysis were used for analysis.

Results
There were no significant differences in the characteristics of patients, operation time, tumor site and the use of postoperative rescue analgesics among the groups. In the first two days after open gastrointestinal tumor surgery, the VAS (expressed by median and interquartile range) of MPCIA (24th h, resting: 1,1; movement: 3,2. 48th h, resting: 0,1; movement: 2,1.) and PCEA (24th h, resting: 0,1; movement: 2,1. 48th h, resting: 0,1; movement: 2,2.) groups were significantly lower than those of OPCIA group (24th h, resting: 2.5,2; movement: 4,2. 48th h, resting: 1.5,1.75; movement: 3,1.) (all p <  0.01). The incidence of postoperative nausea and vomiting in MPCIA group was 13.6% on the first day after surgery, which was significantly higher than that in PCEA group. There was no significant difference in the incidence of other postoperative adverse events. Higher intraoperative sufentanil dosage (OR (95%CI) = 1.017 (1.002–1.031), p = 0.021), lower body mass index (OR (95%CI) = 2.081 (1.059–4.089), p = 0.033), and tumor location above duodenum (OR (95%CI) = 2.280 (1.445–3.596), p <  0.001) were associated with poor postoperative analgesia.

Conclusions
The analgesic effects of PCIA with sufentanil in combination with flurbiprofen axetil and dexmedetomidine on postoperative analgesia was better than that of traditional pure opioids PCIA, and similar with that of PCEA.
Safety assessment of a redirection program using an electronic application for low-acuity patients visiting an emergency department
Authors: Feral-Pierssens Anne-Laure , Morris Judy , Marquis Martin , Daoust Raoul , Cournoyer Alexis , Lessard Justine , Berthelot Simon , Messier Alexandre 
Published: April 2022

AbstractBackgroundEmergency departments (EDs) are operating at or above capacity, which has negative consequences on patients in terms of quality of care and morbi-mortality. Redirection strategies for low-acuity ED patients to primary care practices are usually based on subjective eligibility criteria that sometimes necessitate formal medical assessment. Literature investigating the effect of those interventions is equivocal. The aim of the present study was to assess the safety of a redirection process using an electronic clinical support system used by the triage nurse without physician assessment.MethodsA single cohort observational study was performed in the ED of a level 1 academic trauma center. All low-acuity patients redirected to nearby clinics through a clinical decision support system (February–August 2017) were included. This system uses different sets of medical prerequisites to identify patients eligible to redirection. Data on safety and patient experience were collected through phone questionnaires on day 2 and 10 after ED visit. The primary endpoint was the rate of redirected patients returning to any ED for an unexpected visit within 48 h. Secondary endpoints were the incidence of 7-day return visit and satisfaction rates.ResultsA total of 980 redirected low-acuity patients were included over the period: 18 patients (2.8%) returned unexpectedly to an ED within 48 h and 31 patients (4.8%) within 7 days. No hospital admission or death were reported within 7 days following the first ED visit. Among redirected patients, 81% were satisfied with care provided by the clinic staff.ConclusionThe implementation of a specific electronic-guided decision support redirection protocol appeared to provide safe deferral to nearby clinics for redirected low-acuity patients. EDs are pivotal elements of the healthcare system pathway and redirection process could represent an interesting tool to improve the care to low-acuity patients.
The impact of retirement on inpatient healthcare utilization in Guangzhou, China: a regression discontinuity analysis of 189,031 health insurance claims
Authors: Zhao Xintong , Liu Yuehua , Zhang Xin , Bärnighausen Till , Chen Simiao 
Published: April 2022

AbstractBackgroundPrevious studies suggest that retirement, a major life event, affects overall healthcare utilization. We examine, the effects of retirement on inpatient healthcare utilization, including effect heterogeneity by gender, disease category, and type of health service.MethodsWe used routine health insurance claims data (N= 87,087) spanning the period 2021 - September 2013 from the Urban Employee Basic Medical Insurance (UEBMI), a mandatory social health insurance for working and retired employees in urban China. We applied a non-parametric fuzzy regression discontinuity design using the statutory retirement age in urban China as an exogenous instrument to measure the causal effect of retirement on six measures of inpatient healthcare utilization.ResultsRetirement reduced total hospital costs (-84.71 Chinese Yuan (CNY), 95% confidence interval (CI) -172.03 – 2.61), shortened length of hospital stays (-44.59, 95% CI -70.50 – -18.68), and increased hospital readmissions (0.06, 95% CI 0.00 – 0.12) and primary hospital visits (0.06, 95% CI 0.02 – 0.09) among women. Retirement did not significantly change inpatient healthcare utilization among men. The retirement effects among women varied by disease category. Specifically, retirement substantially increased hospitalizations for non-communicable diseases (NCDs), yet had only modest or no effect on hospitalizations for communicable diseases or injuries. Retirement effects among women also varied by the type of services. For relatively inexpensive services, such as nonoperative treatment, there were surges in the extensive margin (hospital readmission). For relatively expensive and invasive services, such as surgeries, retirement reduced the intensive margin (out-of-pocket expenditures and length of stay).ConclusionsRetirement decreases overall use of inpatient healthcare for women. The examination on the disease-related heterogeneous effects helps with the introduction and implementation of integrated healthcare delivery and appropriate incentive schemes to encourage better use of healthcare resources among older adults.