bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Ambient Fine Particulate Matter and Maternal Vitamin D Levels During The Second Trimester of Pregnancy
Authors: Li Chong , Gong Ya-qin , Xia Yun-yu , Wang Xiao-chun , Chen Lin , Yan Shan-jun , Lu Ke 
Published: February 2022

Abstract
Background: Evidence for an association between the amount of ambient fine particulate matter (PM) in the atmosphere and vitamin D status of pregnant women is limited. We aimed to examine the independent association between ambient fine PM and maternal levels of serum 25-hydroxyvitamin D (25OHD) during the second trimester and to explore possible modifications to the association by meteorological factors. Methods: 27,768 pregnant women presenting for prenatal examination who were tested for serum 25OHD concentration during the second trimester between January 1, 2016, and 31 December, 2020, were included in this retrospective analysis. Exposure to PM was evaluated based on daily average PM with an aerodynamic diameter of ≤2.5 μm (PM2.5) and PM with an aerodynamic diameter of ≤10 μm (PM10). Corresponding meteorological data for daily average atmospheric temperature, atmospheric pressure, relative humidity, sunshine duration, and wind speed, were collected. Results: Vitamin D deficiency (<12 ng/mL), inadequacy (12-20 ng/mL), and adequacy (≥20 ng/mL) were respectively present in 23.5%, 41.3%, and 35.2% of pregnant women during their second trimester. The maximum cumulative effects of PM2.5 occurred at lag 45 days, and the maximum cumulative effects of PM10 occurred at lag 60 days. In crude models, 45-day moving daily average PM2.5 concentrations were negatively associated with 25OHD levels (β, −0.200; 95% CI, −0.206 to −0.193), as were 60-day moving daily average PM10 concentrations (β, −0.142; 95% CI, −0.146 to −0.137). After adjusting for temporal and meteorological factors, the effect values were drastically reduced (adjusted β of PM2.5, −0.032; 95% CI, −0.046 to −0.018; adjusted β of PM10, −0.039; 95% CI, −0.049 to −0.028). Conclusions: Our study showed an independent negative association between ambient fine PM in the atmosphere and maternal serum 25OHD levels during the second trimester of pregnancy. However, the effect values were small after adjusting for temporal and/or meteorological factors, which indicates that ambient fine PM may have a limited influence on maternal serum 25OHD levels.
Development, validity, and reliability of a Japanese version of End-of-Life in Dementia scales
Authors: Toya Sayaka , Uchida Yoko , Yamazaki Tsuneo , Saito Tomoyuki , Chiba Yuhei , Kawashima Tomoyuki , Takai Yukari , Yamaguchi Haruyasu 
Published: February 2022

Abstract

Background: End-of-life care quality should ideally be evaluated by patients themselves. However, patients suffer clinical symptoms and conspicuous cognitive and physical decline in end-stage dementia. Therefore, family members and nurses are often good proxies for evaluating patients’ satisfaction with end-of-life care and symptoms in end-stage dementia. The End-of-Life in Dementia scales, originally written in English, were specifically designed to examine the quality of end-of-life care for persons with dementia. This study aimed to develop a Japanese version of the End-of-Life in Dementia scales and evaluate its validity and reliability in Japan.Methods: The Japanese version of the End-of-Life in Dementia scales (EOLD-J) was created by translating the following original scale measurements: Satisfaction with Care (SWC-EOLD-J), Symptom Management (SM-EOLD-J), and Comfort Assessment in Dying with dementia (CAD-EOLD-J). Participants were 113 family members of deceased residents who received end-of-life care and died at 33 participating nursing homes, and 113 nurses who provided care to the residents. Participants were asked to recall the residents’ last months and respond using the designated scales. The reliability of the scales was evaluated using a Cronbach’s alpha. The construct validity of the relationships between the SWC-EOLD-J scores and the Japanese Decision Regret Scale (DRS-J), the SM-EOLD-J and the short version of Quality of Life Questionnaire for Dementia (short QOL-D), and the CAD-EOLD-J and the short QOL-D were evaluated using Spearman’s rank correlation coefficient. The short QOL-D is composed of positive and negative dimensions.Results: Responses from 83 deceased residents’ family members, and 62 nurses were analyzed. The Cronbach’s alphas of the SWC-EOLD-J was 0.77, the SM-EOLD-J was 0.60, and the CAD-EOLD-J was 0.88. The SWC-EOLD-J score was significantly correlated with DRS-J (γ＝0.504, p < 0.001). The SM-EOLD-J score was significantly correlated with subscale of the short QOL-D: negative dimension ( γ＝0.587, p < 0.001), the CAD-EOLD-J score was significantly correlated with subscale of the short QOL-D: negative dimension (γ＝0.509, p < 0.001). Conclusions: This study developed the EOLD-J and confirmed the reliability and validity of this scale.
Influences of anthropogenic activities on water quality in the Saigon River, Ho Chi Minh City
Authors: Thai-Hoang Le , Thong Truong , Loc Hoang Thai , Van Pham Thi Trang , Thuy Pham Thi Phuong , Thuoc Tran Linh 
Published: February 2022

Abstract
Water quality for the surface water along the Saigon River in Ho Chi Minh City was assessed for four groups of water samples collected at the agricultural, industrial, residential, and less impacted areas. A variety of parameters indicating water quality including physicochemical parameters, nutrients, heavy metals, and antibiotic residues were measured for both the rainy and dry seasons, two main tropical seasons in HCM City using the standard methods. The results showed that the river water in the rainy season was detected with significantly higher values of turbidity, BOD5, PO4-P, NH4-N, NO3-N; and lower values of pH, temperature, conductivity, DO, salinity, Cu, Zn, As, Ni, Hg compared to that in the dry season. Sulfamethoxazole and trimethoprim were highly detected in the industrial areas compared to the agricultural and residential areas. Multivariate analyses suggested that the industrial and residential activities were more important contributors to the pollution of the Saigon River than the agricultural activities in HCM City.
Evaluating the potential impact of energy-efficient ammonia control on the carbon footprint of a full-scale wastewater treatment plant
Authors: Boiocchi Riccardo , Bertanza Giorgio 
Published: February 2022

Abstract
An assessment was performed for elucidating the possible impact of different aeration strategies on the carbon footprint of a full-scale wastewater treatment plant. Using a calibrated model, the impact of different aeration strategies was simulated. The ammonia controller tested showed its ability in ensuring effluent ammonia concentrations compliant with regulation along with significant savings on aeration energy, compared to fixed oxygen set point (DOsp) control strategies. At the same time, nitrous oxide emissions increased due to accumulation of nitrification intermediates. Nevertheless, when coupled with the carbon dioxide emissions due to electrical energy consumption for aeration, the overall carbon footprint was only marginally affected. Using the local average CO2 emission factor, ammonia control slightly reduced the carbon footprint with respect to the scenario where DOsp was fixed at 2 mg·L−1. Conversely, no significant change could be detected when compared against the scenarios where the DOsp was fixed. Overall, the actual impact of ammonia control on the carbon footprint compared to other aeration strategies was found to be strictly connected to the sources of energy employed, where the larger amount of low CO2-emitting energy is, the higher the relative increase in the carbon footprint will be.
Mechanochemistry - A Promising Tool on the Synthesis of Organometallic Pincer
Compounds: Current State and Future Perspectives
Authors: Gómez-Benítez Valente , Germán-Acacio Juan Manuel , Morales-Morales David 
Published: February 2022

Abstract:
Among the different synthethic proceedures available where the reactivity of substances is exploited using solid–state chemistry, such as microwave irradiation, ultrasound (sonochemistry), photochemistry, and mechanochemistry, the latter stands out as a synthetic tool on various areas of chemistry and materials sciences, acquiring great relevance in recent years. Thus, mechanochemistry has been applied in different areas such as organic synthesis, preparation of metal complexes, multicomponent pharmaceutical solid forms, catalysis, polymers, etc. However, despite the attractiveness of this sustainable technique, its application in the synthesis of coordination and organometallic compounds has been very incipient. On the other hand, pincer compounds have been a privileged ligand platform that has been profusely used for the synthesis of organometallic and coordination compounds for the last 20 years, finding applications on a large number of areas of chemistry, this being particularly true in the case of catalysis, being able to activate bonds difficult to activate such as C-H bonds, due in part to their characteristic thermal robustness. In this sense, on this perspective paper we present the current state of mechanochemistry in the preparation of organometallic pincer compounds and discuss future perspectives for the synthesis of these foremost interesting species via mechanochemistry.
Role of Bisphenol A in Autophagy Modulation: Understanding the Molecular Concepts and Therapeutic Options
Authors: Das Srijit , Sirasanagandla Srinivasa Rao , Sofin R.G. Sumesh , Al-Huseini Isehaq 
Published: February 2022

Abstract:
Bisphenol A (4,4′-isopropylidenediphenol) is an organic compound commonly used in plastic bottles, packaging containers, beverages, and resin industry. The adverse effects of bisphenol A in various systems of the body have been studied. Autophagy is a lysosomal degradation process that leads to the regeneration of new cells. The role of bisphenol A in autophagy modulation involved in the pathogenesis of diseases is still debatable. A few research studies have shown bisphenol Ainduced adverse effects to be associated with autophagy dysregulation, while a few have shown the activation of autophagy to be mediated by bisphenol A. Such contrasting views make the subject more interesting and debatable. In the present review, we discuss the different steps of autophagy, genes involved, and the effect of autophagy modulation by bisphenol A on different systems of the body. We also discuss the methods for monitoring autophagy and the roles of drugs, such as chloroquine, verteporfin, and rapamycin, in autophagy. A proper understanding of the role of bisphenol A in the modulation of autophagy may be important for future treatment and drug discovery.
Osthole: Synthesis, Structural Modifications, and Biological Properties
Authors: Xu Hui , Ren Zili , Lv Min 
Published: February 2022

Abstract:
Osthole, a naturally occurring coumarin-type compound, is isolated from the Chinese herbal medicine Cnidium monnieri (L.) and exhibits a broad range of biological properties. In this review, the total synthesis and structural modifications of osthole and its analogs are described. Additionally, the progress on bioactivities of osthole and its analogs has been outlined since 2016. Moreover, the structure-activity relationships and mechanisms of action of osthole and its derivatives are discussed. These can provide references for future design, development, and application of osthole and its analogs as drugs or pesticides in the fields of medicine and agriculture.
Network-based Drug Repurposing: A Critical Review
Authors: Selvaraj Nagaraj , Swaroop Akey Krishna , Nidamanuri Bala sai soujith , Kumar Rajesh R , Natarajan Jawahar , Selvaraj Jubie 
Published: February 2022

Abstract:
New drug development for a disease is a tedious, time-consuming, complex, and expensive
process. Even if it is done, the chances for success of newly developed drugs are still very
low. Modern reports state that repurposing the pre-existing drugs will have more efficient functioning
than newly developed drugs. This repurposing process will save time, reduce expenses and
provide more success rate. The only limitation for this repurposing is getting a desired pharmacological
and characteristic parameter of various drugs from vast data about medications, their effects,
and target mechanisms. This drawback can be avoided by introducing computational methods
of analysis. This includes various network analysis types that use various biological processes
and relationships with various drugs to simplify data interpretation. Some of the data sets now
available in standard, and simplified forms include gene expression, drug-target interactions, protein
networks, electronic health records, clinical trial results, and drug adverse event reports. Integrating
various data sets and interpretation methods allows a more efficient and easy way to repurpose
an exact drug for the desired target and effect. In this review, we are going to discuss briefly
various computational biological network analysis methods like gene regulatory networks, metabolic
networks, protein-protein interaction networks, drug-target interaction networks, drugdisease
association networks, drug-drug interaction networks, drug-side effects networks, integrated
network-based methods, semantic link networks, and isoform-isoform networks. Along with
this, we briefly discussed the drug's limitations, prediction methodologies, and data sets utilised in
various biological networks for drug repurposing.
Digital Health Interventions for Weight Management in Children and Adolescents: Systematic Review and Meta-analysis
Authors: Kouvari Matina , Karipidou Melina , Tsiampalis Thomas , Mamalaki Eirini , Poulimeneas Dimitrios , Bathrellou Eirini , Panagiotakos Demosthenes , Yannakoulia Mary 
Published: February 2022

Background
Recent meta-analyses suggest the use of technology-based interventions as a treatment option for obesity in adulthood. Similar meta-analytic approaches for children are scarce.

Objective
The aim of this meta-analysis is to examine the effect of technology-based interventions on overweight and obesity treatment in children and adolescents.

Methods
A systematic literature search was performed using MEDLINE (PubMed), Scopus, and Cochrane Library for randomized clinical trials to identify interventional studies published between January 2000 and February 2021.

Results
In total, 9 manuscripts from 8 clinical trials of 582 children or adolescents were considered eligible. BMI, BMI z-score, and other BMI-related baseline metrics during and after intervention were considered as primary outcomes. In 7 of 8 studies, a technology-based intervention was applied in addition to conventional care. Of the 8 studies, 6 studies were conducted in the United States, 1 in Australia, and 1 in northwestern Europe. In total, 5 studies included adolescents, whereas the rest addressed children aged 9 to 12 years. Intervention duration ranged from 3 to 24 months. Significant differences between groups in BMI metric changes were reported by 5 of the 8 studies. Pooled analysis revealed an overall significant decrease in BMI metrics in the intervention group (standardized mean difference –0.61, 95% CI –1.10 to –0.13; P=.01). Subgroup analysis revealed that significance was lost in case of no parental involvement (standardized mean difference –0.36, 95% CI –0.83 to 0.11; P=.14). The small number of clinical trials found, the varying study quality, and the study heterogeneity are some limitations of this review.

Conclusions
The studies reported herein describe functional and acceptable technology-based approaches, in addition to conventional treatments, to enhance weight loss in young populations.
Patient Portal Messaging for Asynchronous Virtual Care During the COVID-19 Pandemic: Retrospective Analysis
Authors: Huang Ming , Khurana Aditya , Mastorakos George , Wen Andrew , He Huan , Wang Liwei , Liu Sijia , Wang Yanshan , Zong Nansu , Prigge Julie , Costello Brian , Shah Nilay , Ting Henry , Fan Jungwei , Patten Christi , Liu Hongfang 
Published: February 2022

Background
During the COVID-19 pandemic, patient portals and their message platforms allowed remote access to health care. Utilization patterns in patient messaging during the COVID-19 crisis have not been studied thoroughly. In this work, we propose characterizing patients and their use of asynchronous virtual care for COVID-19 via a retrospective analysis of patient portal messages.

Objective
This study aimed to perform a retrospective analysis of portal messages to probe asynchronous patient responses to the COVID-19 crisis.

Methods
We collected over 2 million patient-generated messages (PGMs) at Mayo Clinic during February 1 to August 31, 2020. We analyzed descriptive statistics on PGMs related to COVID-19 and incorporated patients’ sociodemographic factors into the analysis. We analyzed the PGMs on COVID-19 in terms of COVID-19–related care (eg, COVID-19 symptom self-assessment and COVID-19 tests and results) and other health issues (eg, appointment cancellation, anxiety, and depression).

Results
The majority of PGMs on COVID-19 pertained to COVID-19 symptom self-assessment (42.50%) and COVID-19 tests and results (30.84%). The PGMs related to COVID-19 symptom self-assessment and COVID-19 test results had dynamic patterns and peaks similar to the newly confirmed cases in the United States and in Minnesota. The trend of PGMs related to COVID-19 care plans paralleled trends in newly hospitalized cases and deaths. After an initial peak in March, the PGMs on issues such as appointment cancellations and anxiety regarding COVID-19 displayed a declining trend. The majority of message senders were 30-64 years old, married, female, White, or urban residents. This majority was an even higher proportion among patients who sent portal messages on COVID-19.

Conclusions
During the COVID-19 pandemic, patients increased portal messaging utilization to address health care issues about COVID-19 (in particular, symptom self-assessment and tests and results). Trends in message usage closely followed national trends in new cases and hospitalizations. There is a wide disparity for minority and rural populations in the use of PGMs for addressing the COVID-19 crisis.
Ideas brillantes con estrategias correctas. Entrevista a Felipe Pipe Stein.
Authors: Kweksilber Carola , Giaimo Mariangela 
Published: February 2022

Felipe Stein tiene 37 años y es director de Notable Publicidad. Pipe, como todos lo llaman, ha sido designado presidente del próximo “Desachate” 1 y es, para muchos, un referente creativo.
Pengaruh Penggunaan Media Pembelajaran Flipchart terhadap Hasil Belajar Kognitif Siswa Kelas X SMA Negeri 24 Maluku Tengah
Authors: Talakua Calvin , Aloatuan Febiayu 
Published: February 2022

The accuracy of using the media indirectly will stimulate students to take part in these lessons so that it will affect the good and bad results of student learning. The research design used Two Group Randomized Subjeck Posttest Only, by selecting two classes, namely the experimental class group and the control class group. The experimental class group used Flipchart learning media while the control class used conventional learning models. The same test was given to both classes, namely at the end of the lesson (posttest). From the results obtained, it is known that the cognitive learning outcomes of students using flipchart learning media are much better than students who use conventional learning models. This can be seen from the average score of the experimental class which is much higher than the control class, which is 80.44, while the control class is 58.93. From the results of hypothesis testing, it shows that tcount = 4.26 and ttable = 1.67 at the significant level α = 0.05 with degrees of freedom dk = (34+ 34-2). Based on the criteria for the hypothesis accept H0 if tcount <ttable with degrees of freedom dk = (n_1 + n_ (2) - 2) with a significant level α = 5% for other t values ​​H0 is rejected. Judging from the results of the calculation, it is known that the value of tcount> ttable. So that H_ (0) is rejected and H1 is accepted, which means that there is an effect of Flipchart learning media on cognitive learning outcomes of class X students of SMA Negeri 24 Maluku Tengah.
Abstrak. Ketepatan penggunaan media secara tidak langsung akan menimbulkan rangsangan dari diri siswa untuk mengikuti pelajaran tersebut sehingga akan mempengaruhi baik buruknya hasil belajar siswa. Desain penelitian ini menggunakan Two Group Randomized Subjeck Posttest Only, dengan memilih dua kelas yaitu kelompok kelas eksperimen dan kelompok kelas kontrol. Kelompok kelas eksperimen menggunakan media pembelajaran Flipchart sedangkan kelas kontrol menggunakan model pembelajaran konvensional. Tes yang sama diberikan pada kedua kelas yaitu pada akhir pembelajaran ( postes). Dari hasil yang didapat diketahui hasil belajar kognitif siswa yang menggunakan media pembelajaran Flipchart jauh lebih baik daripada siswa yang menggunakan model pembelajaran konvensional. Hal ini dilihat dari rata-rata skor kelas eksperimen yang jauh lebih tinggi dari kelas kontrol yaitu 80.44 sedangkan kelas kontrol 58,93. Dari hasil pengujian hipotesis menunjukan bahwa thitung = 4.26 ttabel = 1.67 pada taraf singnifikan = 0,05 dengan derajat kebebasan dk = (34+ 34 - 2 ). Berdasarkan kriteria hipotesis terima H0 jika thitung < ttabel dengan derajat kebebasan dk = ( + - 2 ) dengan taraf signifikan = 5% untuk nilai t lainnya H0 ditolak. Dilihat dari hasil perhitungan yang didapat diketahui nilai thitung ttabel Sehingga demikian ditolak dan H1 diterima yang artinya bahwa ada pengaruh media pembelajaran Flipchart terhadap hasil belajar kognitif siswa kleas X SMA Negeri 24 Maluku Tengah.
Hubungan Koordinasi Mata Tangan Dan Kelenturan Terhadap Hasil Precision Shooting pada Atlet Petanque Jambi
Authors: Rasyono Rasyono , Setiowati Ade 
Published: February 2022

Tujuan penelitian ini adalah untuk mengetahui tingkat koordinasi mata tangan dan kelenturan terhadap hasil precision shooting atlet petanque Jambi. Penelitian ini adalah penelitian merupakan penelitian kuantitatif dengan metode korelasional. Koordinasi mata tangan diukur menggunakan tes lempar tangkap bola, kelenturan diukur menggunakan tes sit and reach, sedangkan hasil Precisionshooting diukur dengan tes shooting yang aturannya mengikat dalam pertandingan nomor tersebut. Hasil penelitian menunjukkan ada korelasi antara koordinasi mata tangan (X1) dan kelentukan (X2) terhadap hasil precision shooting (Y) pada atlet petanque Jambi dengan kategori kuat karena hasil perhitungan besar R (korelasi ganda) adalah sebesar 0,75 ≈ 1. Hasil F hitung sebesar 10,94 dan F tabel 3,55. Hal ini berarti F hitung > F tabel (10,94 > 3,55) yang artinya Ho ditolak dan Ha diterima. Dapat disimpulkan bahwa antara koordinasi mata tangan (X1) dan kelentukan (X2) terdapat hubungan terhadap hasil precision shooting (Y) atlet petanque Jambi.
Kata kunci : Koordinasi Mata Tangan, Kelenturan, Precision shooting