bluuebunny/crossref_metadata_2025_split huggingface dataset:
A double‐clipping method to achieve the fatigue damage equivalence between uniaxial and triaxial random vibrations
Authors: Bai Jin , Qiu Yuanying , Li Jing , Wang Haidong , Wang Zhaoxi 
Published: June 2022

AbstractIn this paper, a double‐clipping method dealing with both load spectrum and test time is proposed for fatigue damage equivalence between uniaxial and triaxial random vibrations. The load spectrum is clipped appropriately to avoid strength failure because of triaxial over‐testing by defining the stress margin. The test time is clipped and three criteria for selecting the key equivalent points are presented to achieve fatigue damage equivalence of important components between uniaxial and triaxial random vibrations. The proposed method is verified through a notched specimen and a printed circuit board (PCB), respectively, showing that the double‐clipping method not only avoids over‐testing and saves test time but also provides a valuable reference for formulating triaxial random vibration test standards.
A Tool for Forecasting the Arrival Time of a Tracer or a Pollutant at a Karst Spring
Authors: Preisig Giona , Perrochet Léa 
Published: June 2022

AbstractKarst aquifers are a groundwater resource of global importance. Protection and contamination of karst water resources are often tackled by means of land‐use planning and monitoring of physico‐chemical and microbial water properties coupled to early‐warning systems. However, these solutions of management do not integrate observational data on karst hydrodynamic, for example, tracer tests. Thus, this technical note aims at introducing a straightforward method for forecasting the arrival time of a tracer or a pollutant at a karst spring. Deliverables from the proposed method can assist professionals in the case of a pollution involving a swallow hole of the karst network. The approach is based on repeated tracer testing, gauging of spring flow rate and mathematical curve fitting. Tracer tests and gauging of spring flow rates are repeated under low, middle, and high flow periods. Arrival times of tracer from a given swallow hole of the network are plotted as a function of measured flow rates at the karst spring. The observational data are finally fitted by a mathematical function. Flow rate monitoring at high‐temporal resolution at the karst spring and the mathematical functions allow forecasting the arrival of a tracer or a pollutant at the spring in the case of an accident involving a swallow hole of the network or estimating the duration of a pollution if hydrodynamic conditions do not change abruptly. The applicability of the method is documented by three study sites in Switzerland.
Cutaneous heat and light‐induced pain thresholds in post‐traumatic headache attributed to mild traumatic brain injury
Authors: Starling Amaal J. , Cortez Melissa M. , Jarvis Nicholas R. , Zhang Nan , Porreca Frank , Chong Catherine D. , Schwedt Todd J. 
Published: June 2022

AbstractObjectiveThe purpose of this study was to characterize cutaneous heat and light‐induced pain thresholds in people with post‐traumatic headache (PTH) compared with healthy controls (HCs).BackgroundPhotophobia and allodynia are common in PTH, and there is emerging evidence to support multimodal sensory dysfunction.MethodsIn this age‐ and sex‐matched cohort study, individuals with PTH (n = 20) and HCs (n = 20), aged 18–65 years, were recruited from an institutional database of research volunteers, from the concussion clinic, and via the use of approved flyers posted on the Mayo Clinic Campus in Scottsdale, Arizona. Participants were assessed using the Allodynia Symptom Checklist (ASC‐12), Photosensitivity Assessment Questionnaire (PAQ), State Trait Anxiety Inventory (STAI), and Beck Depression Inventory (BDI). Quantitative sensory testing quantified heat pain thresholds. A light stimulation device quantified light‐induced pain thresholds. Subsequently, heat pain thresholds were obtained immediately, 10, and 40 min after a bright light stressor.ResultsThe mean photophobia symptom severity score, based on the PAQ, was higher in participants with PTH compared with HCs, mean 0.62 (SD = 0.25) versus mean 0.24 (SD = 0.24), p < 0.001. Light‐induced pain thresholds were lower in participants with PTH (median = 90.5 lux and quartiles = 17.8 to 378.5) compared with HCs (median = 863.5 lux and quartiles = 519.9 to 4906.5) and were independent from BDI and STAI (p < 0.001). Allodynia scores did not differ between participants with PTH and HCs after adjusting for BDI and STAI scores. Baseline forehead heat pain thresholds were not different, participants with PTH mean 41.9°C (SD = 0.89) versus HCs mean 44.3°C (SD = 0.89), p = 0.061; however, forearm heat pain thresholds were lower in participants with PTH compared with HCs, mean 40.8°C (SD = 0.80) versus mean 44.4°C (SD = 0.80), p = 0.002. The forehead heat pain threshold change from baseline post bright light stressor in participants with PTH versus HCs was different immediately (mean −1.2 (SD = 0.53), p = 0.025), 10 min (mean −1.8 (SD = 0.74), p = 0.015), and 40 min (mean −1.8 (SD = 0.88), p = 0.047). The forearm heat pain threshold change immediately post bright light stressor in participants with PTH versus HCs was different, mean −1.9°C (SD = 0.58), p = 0.001, however, not different at 10 and 40 min.ConclusionsPhotophobia is higher and light‐induced pain thresholds are lower in participants with PTH. Exposure to a light stressor reduced heat pain thresholds in participants with PTH immediately post bright light stressor, but not in HCs. This study provides evidence for multimodal sensory dysfunction in people with PTH.
An observational study of self‐reported migraine triggers and prospective evaluation of the relationships with occurrence of attacks enabled by a smartphone application (App)
Authors: Casanova Amparo , Vives‐Mestres Marina , Donoghue Stephen , Mian Alec , Martin Paul R. 
Published: June 2022

AbstractObjectiveTo investigate the relationship between self‐reported triggers and the occurrence of migraine attacks using a smartphone application.BackgroundOne of several issues around the study of migraine attack triggers is that limited available evidence supports whether self‐reported triggers can induce a headache on a particular subject.MethodsThis is an observational longitudinal cohort study of individuals with migraine registered to track their headaches prospectively using a smartphone application. For 90 days, participants entered daily data about triggers (potential triggers and premonitory symptoms) that may be associated with attack risk, as well as migraine symptoms. The statistical significance of univariate associations between each trigger and migraine recurrent events was determined for each individual. Statistically identified triggers were then compared to self‐reported triggers.ResultsIn 328 individuals (290/328 [88.4%] female; mean [standard deviation] 4.2 [1.5] migraine attacks/month) the mean (standard deviation) number of triggers moderately or highly endorsed per individual was 28.0 (7.7) in individuals presented with up to 38 possible triggers. Of these, an average (standard deviation) of 2.2 (2.1) triggers per individual were statistically associated with increased risk of attacks. Even the most commonly endorsed triggers (sleep quality, stress, tiredness/fatigue, sleep duration, dehydration, neck pain, missed meals, eyestrain, mean barometric pressure, and anxiety) were statistically associated in fewer than one third of individuals suspecting each, with the exception of neck pain (117/302 [38.7%]).ConclusionsIndividuals with episodic migraine believe that many triggers contribute to their attacks; however, few of these withstand statistical testing at the individual level. Improved personal knowledge of potential triggers and premonitory symptoms may help individuals adopt behavioral changes to mitigate attack risk.
Seasonal changes of internet searching suggest circannual rhythmicity of primary headache disorders
Authors: Radziwon Jakub , Waszak Przemysław 
Published: June 2022

AbstractObjectiveTo investigate whether web searching for headache disorders presents some circannual rhythm.BackgroundStudies support the influence of seasonal rhythms in primary headache disorders such as cluster headache (CH) and episodic migraine. We investigated whether internet users’ searching for headaches reflect these circannual rhythms.MethodsThis was an internet‐based study using the Google Trends (Google) platform. The 10‐year interest across four related topics (headache, migraine, tension‐type headache [TTH], and CH) in 31 European countries was scanned.ResultsSignificant differences between months were found for the topics “headache” and “migraine.” Interest in the former was superior in February (median for all countries, 61 [25th–75th percentile, 45–80]), October (61 [44–75]), and November (61 [45–76]). The lowest search volumes for headache appeared in July (52 [37–66]) (p < 0.001). Migraine was searched most commonly in November (56 [40–73]) and rarely in June (46.5 [31–64]) (p < 0.001). Differences were observed for the topic of headache in Northern Europe (p = 0.001) and for headache and migraine in Central Europe (p < 0.001 and p = 0.016 respectively) but not in the southern region. TTH and CH were apparently less searched and no evident trends regarding them were present (median, 22 [0–44] for TTH and 15 [0–33] for CH; direct popularity comparison: headache 56 [44–63], migraine 16 [12–24], TTH 2 [1–2], and CH 2 [1–2]; between‐month differences, p = 0.168 and p = 0.081 respectively).ConclusionsPublic attention on headache‐related topics on the internet is distributed according to a significant trend of increased searching around spring and autumn. It suggests that a large number of patients may experience some level of seasonal variation in their headaches. Assessment of whether those temporal changes are present in clinical practice is necessary.
Protracted headache after COVID‐19: A case series of 31 patients from a tertiary headache center
Authors: Moskatel Leon S. , Smirnoff Liza 
Published: June 2022

AbstractBackgroundHeadache can be a prominent feature of Post‐Acute Sequelae of SARS‐Cov2 infection (PASC) and previous studies have centered around PASC headaches that have resolved within a month of infection.MethodsWe performed a retrospective chart review of 31 adults evaluated at the Stanford Headache Clinic between September 2020 and January 2022 who developed new or worsening headaches after COVID‐19 infection that were unresolved at time of evaluation for demographics, medical history, and headache diagnosis.ResultsHeadache had been present for a mean duration of 7.4±4.8 months after infection. Notably, 25/31 (81%) had a previous history of headache. The specific features of the headache varied considerably, but 23/31 (74%) met International Classification of Headache Disorders, Third Edition (ICHD‐3) criteria for migraine, with 20/31 (65%) meeting ICHD‐3 criteria for chronic migraine, while only 5/31 (16%) met these criteria before COVID infection. Additionally, full‐time employment decreased from 25/31 (81%) to 17/31 (55%). Prior to establishing care at our clinic, 13/18 (72%) of the patients who were started on preventive medications currently indicated for migraine management, reported a decrease in frequency and/or severity of headaches.ConclusionsOur study presents a group of patients with protracted headache after COVID‐19 infection that includes both patients with a previously lower headache burden who largely exhibited chronification from episodic to chronic migraine, as well as patients with no previous history of headache who meet ICHD‐3 criteria for headache attributed to a systemic viral illness, mostly with a migrainous phenotype.
Effectiveness of root canal instrumentation for the treatment of apical periodontitis: A systematic review and meta‐analysis
Authors: Bürklein Sebastian , Arias Ana 
Published: June 2022

AbstractBackgroundThe development of endodontic instruments has rapidly advanced, but their impact on endodontic outcome parameters remains unclear.ObjectivesThis systematic review aimed to answer the following PICOT questions: In patients with apical periodontitis (P) what is the effectiveness of root canal instrumentation ([Q1] performed with contemporary techniques [I] in comparison with ‘traditional’ techniques [C]] and ([Q2] performed with contemporary engine‐driven NiTi instruments [I] compared with other types of contemporary engine‐driven NiTi instruments [with different design and/or technology] [C]) in terms of clinical and patient‐related outcomes (O)?MethodsAfter PROSPERO protocol registration, a literature search was conducted using Clarivate Analytics' Web of Science, Scopus, PubMed and Cochrane Central Register of Controlled Trials. Grey literature and major journal contents were examined. Two independent reviewers performed the study selection, data extraction and appraisal of included studies. A quantitative meta‐analysis was considered, and statistical heterogeneity and overall quality of evidence were assessed.ResultsNine studies were identified showing substantial methodological differences. Five studies addressed PICOT 1 and three PICOT 2, whereas one study aimed both. A random‐effects meta‐analysis model was considered for the outcome ‘radiographic evidence of normal periodontal ligament space or reduction of apical lesion size’ (PICOT 1) based on three studies with 332 evaluable participants and showed that contemporary instrumentation was associated with a more favourable outcome (p = .005) compared with root canal preparation with stainless steel instruments (odds ratio = 2.07 [95%‐confidence interval = 1.25–3.44]) with no evidence of statistical heterogeneity (I2 = 0%) but low quality of evidence.DiscussionAlbeit a few studies fulfilled eligible criteria, no study had a low risk of bias. Compelling evidence indicating significantly different outcome rates using different endodontic instruments when treating teeth with apical periodontitis is lacking.ConclusionsIn terms of healing, the results of the meta‐analysis determined the higher effectiveness of root canal instrumentation performed with contemporary techniques in comparison with conventional stainless steel instruments in patients with apical periodontitis followed for a minimum of 1 year with low quality of evidence. No differences could be demonstrated between preparations with traditional stainless steel and contemporary NiTi instruments for other clinical and patient‐related outcomes.RegistrationPROSPERO (CRD42021274642).
Activités essentielles, télétravail et surveillance numérique: l'effet panoptique de la pandémie
Authors: ALOISI Antonio , DE STEFANO Valerio 
Published: June 2022

RésuméAvec la pandémie, les pratiques de surveillance numérique ont explosé sur les lieux de travail physiques et virtuels, modifiant les rapports de force professionnels, au profit de l'employeur. Tant les travailleurs essentiels que les télétravailleurs ont fait les frais de cette évolution, qui risque de survivre à la crise. Dans ce contexte, les auteurs s'interrogent sur l'adéquation du cadre juridique européen sur la protection des données. Pour eux, le dialogue social, l'autonomisation des travailleurs et la maîtrise des techniques numériques figurent parmi les moyens à mobiliser pour améliorer la protection des travailleurs tout en promouvant la flexibilité, le bien‐être et la compétitivité.
Outcomes of thrombus aspiration during primary percutaneous coronary intervention for ST‐elevation myocardial infarction
Authors: Rajakariar Kevin , Andrianopoulos Nick , Gayed Daniel , Liang Danlu , Backhouse Brendan , Ajani Andrew E. , Duffy Stephen J. , Brennan Angela , Roberts Louise , Reid Christopher M. , Oqueli Ernesto , Clark David , Freeman Melanie 
Published: June 2022

AbstractBackgroundPrevious large multi‐centre randomised controlled trials have not provided clear benefit with routine intracoronary thrombus aspiration (TA) as an adjunct to primary percutaneous coronary intervention (PCI) in patients with ST‐elevation myocardial infarction (STEMI).AimTo determine whether there is a difference in outcomes with the use of manual TA prior to PCI, compared with PCI alone in a cohort of patients with STEMI.MethodsWe analysed data from 6270 consecutive patients undergoing primary PCI for STEMI prospectively enrolled in the Melbourne Interventional Group registry between 2007 and 2018. Multivariable analysis was performed to determine predictors of 30‐day major adverse cardiovascular and cerebrovascular events (MACCE) and long‐term mortality.ResultsWe compared 1621 (26%) patients undergoing primary PCI with TA to 4649 (74%) patients undergoing PCI alone. Male gender (81% vs 78%; P < 0.01), younger age (61 vs 63 years; P = 0.03), GP‐IIb/IIIa use (76% vs 58%, P < 0.01), and current smoking (40% vs 36%; P < 0.01) were more common in the TA group. TA was more likely to be used in patients with complex lesions (83% vs 66%; P < 0.01) with TIMI 0 flow (77% vs 56%; P < 0.01). No significant difference in post‐procedural TIMI flow, stroke, 30‐day mortality, or long‐term mortality were identified. Multivariable analysis demonstrated a reduction in 30‐day MACCE (hazard ratio (HR) 0.75; confidence interval (CI) 0.63–0.89; P < 0.01) in the TA group, but was not associated with long‐term mortality (HR 0.98; CI 0.85–1.1; P = 0.73).ConclusionThe use of TA in patients undergoing primary PCI for STEMI was not associated with improved short or long‐term mortality when compared with PCI alone.
Compliance with Therapeutic Goods Association prescribing information: weekly or second weekly cetuximab for the treatment of metastatic colorectal cancer
Authors: Loft Matthew , Shapiro Jeremy , Lee Margaret , Wong Rachel , Tie Jeanne , Kosmider Suzanne , Wong Vanessa , Jalali Azim , Lee Belinda , Ananda Sumitra S. , Gibbs Peter 
Published: June 2022

AbstractBackgroundTreatment with cetuximab provides a survival benefit for patients with RAS wild‐type metastatic colorectal cancer (mCRC). Practice‐defining cetuximab studies utilised weekly (q1w) administration. More convenient second weekly (q2w) administration is supported by pharmacokinetic data and a recent meta‐analysis, but large head‐to‐head studies have not been conducted. Therapeutic Goods Association (TGA) prescribing information states cetuximab be administered q1w for all indications.AimTo assess the real‐world use of q1w versus q2w cetuximab schedule and any difference in outcomes.MethodsWe analysed data from a prospective mCRC database at seven Melbourne hospitals from January 2010 to August 2019. Characteristics and outcomes for cetuximab‐treated patients were examined, comparing q1w versus q2w schedules. Progression‐free survival (PFS) and overall survival (OS) were the primary endpoints.ResultsOf 214 eligible patients, 103 (48%) received q1w and 111 (52%) received q2w cetuximab. Q2w cetuximab has been used in >70% of patients from 2015. Q2w was more commonly used in public patients (70% vs 13% in private, P < 0.001), in left‐sided primary tumours (83% vs 68%, P = 0.025) and in combination with chemotherapy (73% q2w vs 40% q1w, P < 0.001). Q2w treatment was less common in BRAFV600E mutated tumours (4% vs 13%, P = 0.001). PFS was similar across all lines of therapy, including when analyses were limited to a left‐sided primary and there was no difference in OS in multivariate analysis.ConclusionThis real‐world analysis shows q2w cetuximab has become the dominant method of administration, despite TGA guidance. Our outcome data adds to other data supporting the use of q2w cetuximab as the standard option. Consideration could be given to modifying current TGA advice.
Effect of body mass index on surgical site wound infection, mortality, and postoperative hospital stay in subjects undergoing possibly curative surgery for colorectal cancer: A meta‐analysis
Authors: Qiao Yating , Zhang Tao , Bai Tianliang , Peng Xinyu , Lin Hengxue , Zhang Aimin 
Published: June 2022

AbstractWe performed a meta‐analysis to evaluate the effect of body mass index on surgical site wound infection, mortality, and postoperative hospital stay in subjects undergoing possibly curative surgery for colorectal cancer. A systematic literature search up to March 2022 was performed and 2247 subjects with possibly curative surgery for colorectal cancer at the baseline of the studies; 2889 of them were obese, and 9358 were non‐obese. Odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) were calculated to assess the effect of body mass index on surgical site wound infection, mortality, and postoperative hospital stay in subjects undergoing possibly curative surgery for colorectal cancer using the dichotomous or contentious methods with a random or fixed‐effect model. The obese subjects had a significantly higher surgical site wound infection after colorectal surgery (OR, 1.87; 95% CI, 1.62‐2.15, P < .001), and higher mortality (OR, 1.58; 95% CI, 1.07‐2.32, P = .02) in subjects with possibly curative surgery for colorectal cancer compared with non‐obese. However, obese did not show any significant difference in postoperative hospital stay (MD, 0.81; 95% CI, −0.030 to 1.92, P = .15) compared with non‐obese in subjects with possibly curative surgery for colorectal cancer. The obese subjects had a significantly higher surgical site wound infection after colorectal surgery, higher mortality, and no significant difference in postoperative hospital stay compared with non‐obese in subjects with possibly curative surgery for colorectal cancer. The analysis of outcomes should be with caution because of the low number of studies in certain comparisons.
Clinicopathological‐genetic features of congenital myasthenic syndrome from a Chinese neuromuscular centre
Authors: Huang Kun , Duan Hui‐Qian , Li Qiu‐Xiang , Luo Yue‐Bei , Bi Fang‐Fang , Yang Huan 
Published: June 2022

AbstractCongenital myasthenic syndrome (CMS) encompasses a heterogeneous group of inherited disorders affecting nerve transmission across the neuromuscular junction. The aim of this study was to characterize the clinical, physiological, pathohistological and genetic features of nine unrelated Chinese patients with CMS from a single neuromuscular centre. A total of nine patients aged from neonates to 34 years were enrolled who exhibited initial symptoms. Physical examinations revealed that all patients exhibited muscle weakness. Muscle biopsies demonstrated multiple myopathological changes, including increased fibre size variation, myofibrillar network disarray, necrosis, myofiber grouping, regeneration, fibre atrophy and angular fibres. Genetic testing revealed six different mutated genes, including AGRN (2/9), CHRNE (1/9), GFPT1 (1/9), GMPPB (1/9), PLEC (3/9) and SCN4A (1/9). In addition, patients exhibited differential responses to pharmacological treatment. Prompt utilization of genetic testing will identify novel variants and expand our understanding of the phenotype of this rare syndrome. Our findings contribute to the clinical, pathohistological and genetic spectrum of congenital myasthenic syndrome in China.