bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS MORFOLOGI KOTA BATAM STUDI KASUS KAMPUNG SEI JODOH
Authors: Murtiono Hendro 
Published: September 2022

Abstract: activities to expand indefinitely. The physical city rapidly grows and develops horisontaly with a gigantic scale occupying the surrounding area urban growth does not always start from the center of the city but move from the suburbs.The city’s morphologi has undergone a metamorphosis from tradisional houses into the business and economic center city of Batam. Morphologi is an approach in understanding the logistics form of acity and regional space. In the process of realizing the city’s morphologi about as growth of the city’s past history. The metamorphosis of the jodoh viilage which at the beginning of it.s existense in Batam city was a traditional fishing village with thousand of stilt houses with thatched roofs, now with a significant shift in civilization has made the jodoh village a center of crowds and a traditional trading center in BatamAbstrak: Pertumbuhan layaknya sebuah perkotaan telah menjadi fenomena di dunia,hal ini menyebabkan kota yang tadinya baru memulai aktivitasnya menjadi berkembang dengan cepatnya. Kondisi dari fisik sebuah kota yang dengan cepat berkembang secara horisontal dengan skala yang besar dan mempenagruhi kawasan yang berada disekitarnya. Perkembangan sebuah kota tidak selalu dimulai dari kawasan pusat kota tersebut melainkan bisa bergeser ataupun berpindah ke kawasan pinggiran. Morfologi sebuah kota mengalami metamorfosa atau perubahan dimana yang tadinya rumah rumah tradisional menjadi pusat bisnis dan perekonomian dikota Batam.Morfologi merupakan salah satu pendekatan dalam memahami bentuk fisik sebuah ruang kota dan kawasan dimana didalam proses perwujudannya, konsep morfologi kota dapat dilihat sebagai perubahan dari sejarah kota masalalu. Metamorfosa kampung jodoh yang pada awal ekistensinya kota batam ini adalah sebuah kampung nelayan tradisional dengan ribuan rumah panggung berdinding papan beratap rumbia, sekarang dengan pergeseran peradaban yang signifikan menjadikan kampung jodoh sebagai pusat keramaian dan sentra dagang tradisional batam.
HIERARKI DAN INFORMALITAS SOSIAL PADA PRODUKSI RUANG DI NAGARI PARIANGAN, SUMATERA BARAT
Authors: Putra Juli Yanda , Ekomadyo Agus S. 
Published: September 2022

Abstract: Nagari Pariangan is an old village in Minangkabau, West Sumatra. Nagari is a customary law community unit consisting of a collection of several tribes and has its own territorial boundaries. The phenomenon of the nagari shows the production of social space based on Minangkabau villages culture. The purpose of this paper is to determine the relationship between the architectural elements of Nagari Pariangan and their relationship with their environment associated with the spatial production, uses Spatializing Culture approach (Low, 2017). Research is conducted by ethnographic approach data is collected by observation and in-depth interview. It is resulted, that the spaces of Nagari are formed mostly based on the social hierarchy of community, but also provided spaces for informal relationship. Political culture of the Nagari is important factor in governing spatial production by the traditonal community, but the other side, the community also produces their own communal spaces.Abstrak: Nagari Pariangan adalah nagari tuo yang ada di Minangkabau, Sumatra Barat. Nagari merupakan satu kesatuan masyarakat hukum adat yang terdiri dari kumpulan beberapa suku dan mempunyai batas wilayahnya sendiri. Fenomena Nagari menunjukkan adanya produksi ruang sosial berdasarkan budaya pada Nagari di Minangkabau. Tujuan dari penulisan ini adalah untuk mengetahui hubungan antara elemen arsitektur pembentuk Nagari Pariangan dan relasi sosial yang memproduksi ruang yang ditelaah melalui pendekatan Spatializing Culture (Low, 2017). Penelitian ini dilakukan dengan pendekatan etnografi, data dikumpulkan lewat observasi dan wawancara mendalam. Ditemukan, ruang-ruang Nagari terbentuk berdasarkan hierarki sosial, namun tetap tersedia ruang-ruang informal. Budaya politik dari Nagari menjadi faktor terpenting dalam tata kelola produksi ruang oleh komunitas adat, namun di sisi lain, komunitas Adat juga memproduksi ruang-ruang komunalnya sendiri.
PENERAPAN METODE LATIHAN PADA PERMAINAN OUTDOOR UNTUK MENINGKATKAN KEMAMPUAN MOTORIK KASAR DAN KETERAMPILAN SOSIAL (Studi Pada Kelompok B TK Negeri 20 Bengkulu Selatan
Authors: Kusairi Herna 
Published: September 2022

The objectives of this research are 1). To describe the application of drill methods in outdoor games to improve rough motoryc movements of students at TK Negeri 20 Bengkulu Selatan; 2) To describe the application of drill methods in outdoor games to improve social relationships of students at TK Negeri 20 Bengkulu Selatan. This research uses Class Action Research (CAR). The subject of this research is 15 students of B group at TK Negeri 20 Bengkulu Selatan. The collecting data used in this research is the student observation sheet. The data is analyzed by using mean and t-test. This research shows that 1) the application of drill methods in outdoor games can improve rough motoryc movements of students at TK Negeri 20 Bengkulu Selatan; 2) the application of drill methods in outdoor games can improve social relationships of students at TK Negeri 20 Bengkulu Selatan
Development of Internal Quality Assurance System Model for Pesantren Using the 2020 Education Unit Accreditation Instrument
Authors: Lathifah Zahra Khusnul , Setyaningsih Sri , Wulandari Dian 
Published: September 2022

This study aims to analyze and understand the Development of pesantren (Islamic Boarding School's) Internal Quality Assurance System (SPMI) Model Based on the Education Unit Accreditation Instrument (IASP) 2020. This study uses a Research and Development (R&D) approach. The data collection technique is done through interviews, observation and documentation. While the data analysis was carried out in a circular manner, starting from data collection, data reduction and drawing conclusions. The results show that pesantren Internal Quality Assurance System (SPMI) Model which refers to the Education Unit Accreditation Instrument (IASP) 2020 was developed with a quality scheme in four main areas: firstly, the quality of graduates, secondly, the quality of the process, thirdly, the quality of minimum standard achievements, and fourthly, the quality of management. (Islamic boarding school management).
Niteliksiz İşgücü Göçünün Ekonomik Büyümeye Etkisi: OECD Ülkeleri Örneği
Authors: ASYA Gökhan , AKTAŞ Adem 
Published: September 2022

Küresel rekabetin seyrinin emekten bilgiye doğru şekillendiği cağımızda bilginin önemi her geçen gün artarak yükselmektedir. Bu yükselişe uyum sağlayan ülkeler kendi üretim faktörlerini bütünüyle bu değişime uyarlama gayreti içindedirler. Bununla birlikte, bilgi çağına henüz kendini uyarlayamamış, gelişimini istenilen düzeye ulaştıramamış, ülkelerden alınan niteliksiz iş gücü göçü ev sahibi ülke ekonomilerini nasıl etkilediği merak konusudur.
Bu çalışmada, bilgi ekonomisinin bilincinde olan ve dışardan göç alan OECD ülkelerinin almış olduğu niteliksiz iş gücü göçünün ekonomik büyümeye etkisi incelenmektedir. 31 OECD ülkesinin 2000-2015 dönemi yıllık verileri kullanılarak panel veri analizi yapılmıştır. Kurulan modelde bağımlı değişken olarak Reel GSYİH, bağımsız değişken olarak ise niteliksiz iş gücü göçü istihdamı, beşeri sermaye endeksi ve nüfus seçilmiştir.
Bulgulardan elde edilen sonuç, niteliksiz iş gücü göçü istihdamı ile reel GSYİH arasında pozitif ve anlamlı bir ilişki olduğu şeklindedir. Bununla birlikte beşeri sermaye ve reel GSYİH arasında da anlamlı ve pozitif bir ilişkinin varlığı gözlemlenmiştir. Fakat beşeri sermayenin Reel GSYİH üzerindeki etkisinin niteliksiz iş gücü göçü istihdamına kıyasen daha büyük olduğu tespit edilmiştir.
Process method of Si3N4 ceramic brazing sealed cavity for high-temperature application
Authors: Li Chen , Fang Zhihong , Sun Boshan , Xiong Jijun , Xu Aodi , Guo Ximing , Hong Yingping 
Published: September 2022

The process method of a Si3N4 ceramic sealed cavity is realized by vacuum brazing and chemical reaction at 1,100°C and 0.5 MPa pressure. Through the combination of Si3N4 ceramic polishing and thinning, inductively coupled plasma etching, and high-temperature metal filler (Ti-Zr-Cu-Ni) brazing process, a vacuum-sealed cavity suitable for high-temperature environments was prepared. The cross section of the bonding interface was characterized by scanning electron microscope (SEM) and energy dispersive spectrometer (EDS), which indicated that the two Si3N4 ceramic were well bonded, the cavity structure remained intact, and the bonding interface strength exceeded 5.13 MPa. Furthermore, it retained its strong bonding strength after in high-temperature environments of 1,000, 1,050, and 1,100°C for 1 h. This indicates that a brazed vacuum-sealed cavity can be used in high-temperature environments. Through the proposed method, pressure sensor that can withstand high temperatures can be developed.
Metagenomic next-generation sequencing of cell-free and whole-cell DNA in diagnosing central nervous system infections
Authors: Yu Lili , Zhang Ye , Zhou Jiemin , Zhang Yu , Qi Xuejiao , Bai Kaixuan , Lou Zheng , Li Yi , Xia Han , Bu Hui 
Published: September 2022

BackgroundCentral nervous system (CNS) infections pose a fatal risk to patients. However, the limited sample volumes of cerebrospinal fluid (CSF) and low detection efficiency seriously hinder the accurate detection of pathogens using conventional methods.MethodsWe evaluated the performance of metagenomics next-generation sequencing (mNGS) in diagnosing CNS infections. CSF samples from 390 patients clinically diagnosed with CNS infections were used for the mNGS of cell-free DNA (cfDNA) (n =394) and whole-cell DNA (wcDNA) (n =150).ResultsThe sensitivity of mNGS using cfDNA was 60.2% (237/394, 95% confidence interval [CI] 55.1%–65.0%), higher than that of mNGS using wcDNA (32.0%, 95% [CI] 24.8%–40.2%, 48/150) and conventional methods (20.9%, 95% [CI] 16.2%–26.5%, 54/258) (P &lt; 0.01, respectively). The accuracy of mNGS using cfDNA in positive samples was 82.6%. Most of viral (72.6%) and mycobacterial (68.8%) pathogens were only detected by the mNGS of cfDNA. Meningitis and encephalitis with Streptococcus pneumoniae infection might be more likely to result in critically ill diseases, while Human alphaherpesvirus 3 was prone to cause non-critically ill diseases.ConclusionsThis is the first report on evaluating and emphasizing the importance of mNGS using CSF cfDNA in diagnosing CNS infections, and its extensive application in diagnosing CNS infections could be expected, especially for viral and mycobacterial CNS infections.
Personalized allocation of acetylsalicylic acid therapy for secondary prevention of coronary artery disease
Authors: Hegde Nischal N. , Mathew Navin , Thachathodiyl Rajesh , Menon Jaideep C. 
Published: September 2022

BackgroundA single-daily dose of 75 mg of acetylsalicylic acid inhibits 100% of thromboxane-B2 synthesis within 30–60 min. Thromboxane-B2 synthesis then recovers slowly as new platelets are released from the bone marrow. Normally, only 10% of the platelets are replaced daily by new platelets entering circulation. Hence, 24 h after a dose of acetylsalicylic acid, thromboxane-B2 synthesis is still suppressed by more than 90%. Hence, there is an adequate anti-platelet effect even after 24 h of acetylsalicylic acid intake. However, some patients treated with once-daily acetylsalicylic acid may have an incomplete 24-h suppression of thromboxane-B2 synthesis due to increased platelet turnover. The response could be improved in such patients by twice-daily acetylsalicylic acid administration. This study aimed to identify such a group of patients who would benefit from a twice-daily dose of acetylsalicylic acid.Materials and methodsSerum thromboxane-B2 levels were measured in 79 patients with coronary artery disease receiving 75 mg of acetylsalicylic acid for secondary prophylaxis. Serum levels of thromboxane-B2 were measured after 4 and 24 h of acetylsalicylic acid intake. Patients were then classified into three groups: steady suppression group (serum thromboxane B2 is adequately suppressed at 4 and 24 h), i.e., adequate response to acetylsalicylic acid; fast recovery group (more than 10% rise in serum thromboxane-B2 levels at 24-h when compared to at 4-h) and non-responders (serum thromboxane-B2 levels of &gt;3,100 pg/ml after 4 h of acetylsalicylic acid intake). Patients in the fast recovery group were given twice-daily acetylsalicylic acid and thromboxane-B2 levels were re-measured.ResultsA total of 20 patients (24.3%) had steady suppression of thromboxane-B2 and 11 patients (13.9%) belonged to the fast recovery group, i.e., thromboxane-B2 levels were adequately suppressed at 4 h but had recovered by more than 10% at 24 h; which was adequately suppressed by twice-daily acetylsalicylic acid (p 0.004). A total of 48 patients (60.8%) were non-responders.ConclusionTwice-daily acetylsalicylic acid may be beneficial if serum thromboxane-B2 levels at 4 h are &lt;3,100 and &gt;3,100 pg/ml at 24 h. If thromboxane-B2 levels at 4 and 24 h is &lt;3100 pg/ml but if there is a &gt;10% rise in serum thromboxane B2 at 24 h as compared to that at 4 h, then twice-daily acetylsalicylic acid should be considered. However, if thromboxane-B2 at 4 and 24 h is &gt;3,100 pg/ml consider switching over to a P2Y12 inhibitor.
Diagnostic model for predicting hyperuricemia based on alterations of the gut microbiome in individuals with different serum uric acid levels
Authors: Liang Meiting , Liu Jingkun , Chen Wujin , He Yi , Kahaer Mayina , Li Rui , Tian Tingting , Liu Yezhou , Bai Bing , Cui Yuena , Yang Shanshan , Xiong Wenjuan , Ma Yan , Zhang Bei , Sun Yuping 
Published: September 2022

BackgroundWe aimed to assess the differences in the gut microbiome among participants with different uric acid levels (hyperuricemia [HUA] patients, low serum uric acid [LSU] patients, and controls with normal levels) and to develop a model to predict HUA based on microbial biomarkers.MethodsWe sequenced the V3-V4 variable region of the 16S rDNA gene in 168 fecal samples from HUA patients (n=50), LSU patients (n=61), and controls (n=57). We then analyzed the differences in the gut microbiome between these groups. To identify gut microbial biomarkers, the 107 HUA patients and controls were randomly divided (2:1) into development and validation groups and 10-fold cross-validation of a random forest model was performed. We then established three diagnostic models: a clinical model, microbial biomarker model, and combined model.ResultsThe gut microbial α diversity, in terms of the Shannon and Simpson indices, was decreased in LSU and HUA patients compared to controls, but only the decreases in the HUA group were significant (P=0.0029 and P=0.013, respectively). The phylum Proteobacteria (P&lt;0.001) and genus Bacteroides (P=0.02) were significantly increased in HUA patients compared to controls, while the genus Ruminococcaceae_Ruminococcus was decreased (P=0.02). Twelve microbial biomarkers were identified. The area under the curve (AUC) for these biomarkers in the development group was 84.9% (P&lt;0.001). Notably, an AUC of 89.1% (P&lt;0.001) was achieved by combining the microbial biomarkers and clinical factors.ConclusionsThe combined model is a reliable tool for predicting HUA and could be used to assist in the clinical evaluation of patients and prevention of HUA.
Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis via the inhibition of the SIRT3/SMCT1 pathway
Authors: Xie Jinlan , Zhong Feifei , Guo Zhenhong , Li Xinran , Wang Jingyu , Gao Zhongai , Chang Baocheng , Yang Juhong 
Published: September 2022

ObjectiveTo investigate the effects and mechanism of hyperinsulinemia on the metabolic switch to β‐hydroxybutyrate (BHB) absorption and utilization under a starvation or hypoxic environment in proximal tubular epithelial cells.MethodsA high-fat diet-induced hyperinsulinemia model in ZDF rats was used to test the expression of key enzymes/proteins of ketone body metabolism in the kidney. Notably, 12-week-old renal tubule SMCT1 specific knockout mice (SMCT1 flox/floxCre+) and control mice (SMCT1 flox/floxCre-) were used to confirm the roles of SMCT1 in kidney protection under starvation. The changes of key enzymes/proteins of energy metabolism, mitochondrial function, and albumin endocytosis in HK2 cells under low glucose/hypoxic environments with or without 50 ng/mL insulin were studied. Silent information regulation 2 homolog 3 (SIRT3) was overexpressed to evaluate the effect of hyperinsulinemia on the metabolic switch to BHB absorption and utilization through the SIRT3/SMCT1 pathway in HK2 cells.ResultsIn ZDF rats, the expression of HMGCS2 increased, the SMCT1 expression decreased, while SCOT remained unchanged. In renal tubule SMCT1 gene-specific knockout mice, starvation for 48 h induced an increase in the levels of urine retinol-binding protein, N-acetyl-β-glucosaminidase, and transferrin, which reflected tubular damages. In HK2 cells under an environment of starvation and hypoxia, the levels of key enzymes related to fatty acid oxidation and ketone body metabolism were increased, whereas glucose glycolysis did not change. The addition of 2 mmol/l BHB improved ATP production, mitochondrial biosynthesis, and endocytic albumin function, while cell apoptosis was reduced in HK2 cells. The addition of 50 ng/ml insulin resulted in the decreased expression of SMCT1 along with an impaired mitochondrial function, decreased ATP production, and increased apoptosis. The overexpression of SIRT3 or SMCT1 reversed these alterations induced by a high level of insulin both in low-glucose and hypoxic environments.ConclusionsThe increased absorption and utilization of BHB is part of the metabolic flexibility of renal tubular epithelial cells under starvation and hypoxic environments, which exhibits a protective effect on renal tubular epithelial cells by improving the mitochondrial function and cell survival. Moreover, hyperinsulinemia inhibits the absorption of BHB through the inhibition of the SIRT3/SMCT1 pathway.
Decreased Urine N6-methyladenosine level is closely associated with the presence of diabetic nephropathy in type 2 diabetes mellitus
Authors: Wan Shu-jun , Hua Qiang , Xing Yu-jie , Cheng Yi , Zhou Si-min , Sun Yue , Yao Xin-ming , Meng Xiang-jian , Cheng Jin-han , Wu Han , Zhai Qing , Zhang Yan , Kong Xiang , Lv Kun 
Published: September 2022

BackgroundTo investigate the dynamic changes of urine N6-methyladenosine (m6A) levels in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) and evaluate the clinical significance.MethodsFirst, the levels of urine m6A were examined and compared among 62 patients with T2DM, 70 patients with DN, and 52 age- and gender-matched normal glucose tolerant subjects (NGT) by using a MethyIFIashTM Urine m6A Quantification Kit. Subsequently, we compared the concentrations of urine m6A between different stages of DN. Moreover, statistical analysis was performed to evaluate the association of urine m6A with DN.ResultsThe levels of m6A were significantly decreased in patients with DN [(16.10 ± 6.48) ng/ml], compared with NGT [(23.12 ± 7.52) ng/ml, P &lt; 0.0001] and patients with T2DM [(20.39 ± 7.16) ng/ml, P &lt; 0.0001]. Moreover, the concentrations of urine m6A were obviously reduced with the deterioration of DN. Pearson rank correlation and regression analyses revealed that m6A was significantly associated with DN (P &lt; 0.05). The areas under the receiver operator characteristics curve (AUC) were 0.783 (95% CI, 0.699 – 0.867, P &lt; 0.0001) for the DN and NGT groups, and 0.737 (95% CI, 0.639 – 0.835, P &lt; 0.0001) for the macroalbuminuria and normoalbuminuria groups, and the optimal cutoff value for m6A to distinguish the DN from NGT and the macroalbuminuria from normoalbuminuria cases was 0.4687 (diagnostic sensitivity, 71%; diagnostic specificity, 76%) and 0.4494 (diagnostic sensitivity, 79%; diagnostic specificity, 66%), respectively.ConclusionsThe levels of urine m6A are significantly decreased in patients with DN and change with the deterioration of DN, which could serve as a prospective biomarker for the diagnosis of DN.
Temperature distribution simulation and thermal properties investigation of hollow slab beam based on meteorological data
Authors: Zeng Guosheng S , Song Jun , Zhu Chaoyu Y 
Published: September 2022

Natural environment has a great impact on the performance of bridge structures, such as the ambient temperature, solar radiation, climate extremes and so on. Due to the lack of regional pertinence in the provisions of the existing specifications on the temperature load standard, and the lack of verification of its adaptability of hollow slab beam bridge in the reconstruction and expansion project, it is necessary to study the temperature load of the beam based on the temperature data of the area where the bridge site is located. Based on the measured meteorological data, the cross-section temperature distribution characteristics of the hollow slab beam and the temperature load effect were investigated. The vertical temperature load model of the short and medium-span hollow slab beam was proposed according to the simplified temperature curve. Firstly, based on the annual measured meteorological data, the plane model was established to analyze the temperature distribution characteristics of the hollow slab beam. Secondly, according to the temperature field distribution of the beam cross-section, the solid model of 16 m hollow slab beam was established to analyze the distribution of the temperature load effect. Finally, based on the preliminarily proposed temperature curve, vertical temperature load models were proposed by introducing the theory of extreme value extrapolation. The studies have shown that the temperature of the hollow slab beam is approximately horizontal distributed, and temperature extreme value appear at the location of the beam web. The roof and floor of the hollow slab beam are compressed and the webs are tensioned in the positive temperature difference state, the stress condition is opposite under the negative temperature difference state. The positive and negative temperature load models can meet the extrapolation requirements of the bridge design reference period. This study innovatively proposed a temperature load model based on the temperature curve corresponding to the most unfavorable effect of the beam. The extrapolation idea in the derivation of vehicle load model is introduced as well. And a temperature load model suitable for the extension of hollow slab bridges in Guangdong is established in this study.