bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimisation of acute pain treatment in children in abdominal surgery at the stages of the perioperative period
Authors: Satvaldieva Elmira , Kuralov Eldor Turgun ugli 
Published: October 2022

The aim of the study. To improve the quality of perioperative analgesia by combined multimodal use of paracetamol and ketorolac tromethamine in children after abdominal surgery.
Materials and methods. 48 children (6-17 years old) with choledochal, pancreatic cysts, hepatic echinococcosis, and abdominal trauma. The study period was from January 2021 to January 2022. Group 1 (main group, n=28): baseline analgesia - 15 min before surgery, intravenous paracetamol administration at 25-30 mg/kg. In order to prevent postoperative pain syndrome 15 minutes before the end of the surgery, we administered ketorolac and tromethamine in a dose of 0.5 mg/kg. Pain relief was repeated 6-8 h later with ketorolac at a dose of 0.5 mg/kg. Group 2 (comparison, n=20), who received 0.2 – 0.3 mg/kg promedol (trimeperidin) in the postoperative period. Both groups received standard endotracheal anaesthesia (propofol + fentanyl + arduan against the background of Low-flow anaesthesia with sevoflurane MAK=1). Systemic haemodynamics, C-reactive protein, and glucose were investigated, and a visual analogue scale was applied at the main stages of the study.
Results: Analysis of the parameters of central hemodynamics, parameters of the operational stress response and clinical data showed that in the postoperative period, sufficient analgesic effect was established only in children in group 1 with the preventive combined administration of paracetamol and ketorolac on the operating table, which allows recommending them in the practice of perioperative analgesia during abdominal surgical interventions.
Conclusions. Optimised method of preventive (preoperative) use of paracetamol in children at a dose of 25-30 mg/kg during abdominal surgery followed by administration of ketorolac tromethamine (15 minutes before the end of the surgery) increases the degree of nociceptive protection. It ensures high efficiency of postoperative pain relief, which allows to recommend it in the practice of perioperative analgesia for the above abdominal surgical interventions in children
Evaluation of the efficacy of paravertebral blockade as a component of combined anesthesia in the surgical treatment of pulmonary cancer
Authors: Suprun Andrey , Lysenko Victor 
Published: October 2022

The aim. The paper evaluates the effectiveness of implemented combined anaesthesia (inhalation with paravertebral blockade) in comparison with inhalation anaesthesia (IA) and total intravenous anaesthesia (TVA) at the stages of surgery and the early postoperative period in the surgical treatment of cancer lungs.
Methods. The study involved 60 patients with an average age of 55±5.6 years, physical status ASA II–III, who underwent open surgical interventions in the scope of frontal or pneumonectomy or resection of part of the lung. Patients were divided into 3 groups depending on the method of anaesthetic support at the stage of anaesthesia maintenance: I (n=20) – combined anaesthesia was used; II (n=20) – IA with sevoflurane; III (n=20) – TVA. In addition, the leading indicators of central hemodynamics were studied; oxygen saturation (SaO2), CO2 ET (concentration of CO2 in exhaled air), cortisol level, and indicators of acid-base status were determined. The effectiveness of analgesia in the early postoperative period was assessed using a visual analogue scale (VAS) at 10 control stages. Fasting intensity was recorded after waking up, after extubation, after 1 h. after surgery, on the first day after surgery every 3 h. and once a day from the 2nd day for 5-6 days.
Results. The studied clinical and laboratory indicators indicated an adequate course of the applied type of anaesthesia. In the dynamics of pain syndrome (PS) in the postoperative period, a gradual subjective increase of pain syndrome was noted until the 3rd day, including a decrease in pain on the 4th - 6th day. It was established that when using combined anaesthesia, a less significant level of PS, according to VAS, was noted compared to inhalation anaesthesia and the use of TVA.
Conclusions. Combined anaesthesia (inhalation with PVB) can more effectively prevent the development of post-thoracotomy pain syndrome (PTPS) compared to TVA and IA in the surgical treatment of lung cancer
Forensic classification of battle axes
Authors: Nikitiuk Vitalii , Yaroshenko Ihor 
Published: October 2022

The essence of the definition of "battle axe" has been investigated. It is determined, that it is an axe, intended for use as a cutting, chopping-stabbing, chopping-slicing and chopping-stabbing-cutting cold weapon, and consists of an iron (percussive part with a blade) and a hatchet (handle). The history of the development of battle axes - from stone to modern ones - has been studied. The material for making axes has been determined - stone, metal and other materials. For foot soldiers, a battle ax was often the main weapon, for horsemen - an auxiliary one. Battle axes were used mainly for close combat. Some types of axes were used for throwing. Axes were also widely used as ceremonial weapons. The battle ax has spread all over the world, different modifications of it have appeared in different regions. The reasons for the spread of the battle ax were the relative cheapness compared to the sword and the personal preferences of the owner. The purpose of the study was the formation of a forensic battle axes classification. The materials of the research were literary sources, scientific works and expert conclusions on the studied issues. On the basis of the conducted research, a forensic classification of battle axes is proposed.
The main characteristics of battle axes include their type; method of action; application method; iron manufacturing technology; number of blades; blade shape; blade width; the presence of additional striking elements; iron material; the shape (cross-section) of the eyelet; the method of attaching the iron to the ax; ax length; ax shape; ax material; the way of holding (grasping) the ax; availability of additional accessories, tuning; the method of making an ax; time of manufacture; construction decoration
The legal basis for the compulsory vaccination of higher education institutions' staff in the COVID-19 pandemic
Authors: Khatniuk Natalia , Pobiyanska Nelly , Levytska Anastasia 
Published: October 2022

The research consists in a theoretical analysis and legislative definition of the concept of mandatory vaccination of employees of higher education institutions and the legal status of dismissed employees who were not vaccinated during the COVID-19 pandemic, regarding the performance of their employment duties under an employment agreement or contract. The authors draw attention to the peculiarities of the legislative regulation of the epidemic and pandemic in Ukraine, as well as the impact of such provisions on the labor relations between employees and employers of individuals and legal entities.
The issues of legality and legislative validity of the application of mandatory vaccination for employees of higher education institutions are revealed, as well as the legal consequences of suspension from work of employees who refused to be vaccinated during the COVID-19 pandemic under national legislation, the rules of conduct of the employer in such circumstances and the legal regime of the pandemic as a social phenomenon, determined by the legislator, are analyzed.
The legal grounds and ways to protect the labor rights and legitimate interests of employees of higher education institutions are investigated. The list of all categories of employees who are obliged to be vaccinated is revealed. The options for the behavior of the employer and the employee in case of such force majeure are proposed. The legal provisions on the protection of the rights and legitimate interests of employees in the event of a pandemic and the procedure for their dismissal from work in the absence of vaccination are analyzed
EVOLUTIONARY METHOD FOR SYNTHESIS SPIKING NEURAL NETWORKS USING THE NEUROPATTHERN MECHANISM
Authors: Leoshchenko S. D. , Oliinyk A. O. , Subbotin S. A. , Gofman Ye. O. , Ilyashenko M. B. 
Published: October 2022

Context. The problem of synthesizing pulsed neural networks based on an evolutionary approach to the synthesis of artificial neural networks using a neuropathic mechanism for constructing diagnostic models with a high level of accuracy is considered. The object of research is the process of synthesis of pulsed neural networks using an evolutionary approach and a neuropathic mechanism.
Objective of the work is to develop a method for synthesizing pulsed neural networks based on an evolutionary approach using a neuropathic mechanism to build diagnostic models with a high level of accuracy of work.
Method. A method for synthesizing pulsed neural networks based on an evolutionary approach is proposed. At the beginning, a population of pulsed neural networks is generated, and a neuropathic mechanism is used for their encoding and further development, which consists in separate encoding of neurons with different activation functions that are determined beforehand. So each pattern with multiple entry points can define the relationship between a pair of points. In the future, this simplifies the evolutionary development of networks. To decipher a pulsed neural network from a pattern, the coordinates for a pair of neurons are passed to the network that creates the pattern. The network output determines the weight and delay of the connection between two neurons in a pulsed neural network. After that, you can evaluate each neuromodel after evolutionary changes and check the criteria for stopping synthesis. This method allows you to reduce the resource intensity during network synthesis by abstracting the evolutionary changes of the network pattern from itself.
Results. The developed method is implemented and investigated on the example of the synthesis of a pulsed neural network for use as a model for technical diagnostics. Using the developed method to increase the accuracy of the neuromodel with a test sample by 20%, depending on the computing resources used.
Conclusions. The conducted experiments confirmed the operability of the proposed mathematical software and allow us to recommend it for use in practice in the synthesis of pulsed neural networks as the basis of diagnostic models for further automation of tasks of diagnostics, forecasting, evaluation and pattern recognition using big data. Prospects for further research may lie in the use of a neuropathic mechanism for indirect encoding of pulsed neural networks, which will provide even more compact data storage and speed up the synthesis process.
Testican-2 Is Associated with Reduced Risk of Incident ESKD
Authors: Wen Donghai , Zhou Linda , Zheng Zihe , Surapaneni Aditya , Ballantyne Christie M. , Hoogeveen Ron C. , Shlipak Michael G. , Waikar Sushrut S. , Vasan Ramachandran S. , Kimmel Paul L. , Dubin Ruth F. , Deo Rajat , Feldman Harold I. , Ganz Peter , Coresh Josef , Grams Morgan E. , Rhee Eugene P. ,   on behalf of the CKD Biomarkers Consortium
Published: October 2022

Significance Statement
Standard blood markers of kidney function undergo renal clearance and are thus inversely correlated with estimated glomerular filtration rate (eGFR). Recent work has shown that blood levels of the podocyte-derived protein testican-2 are positively correlated with eGFR among individuals with relatively normal kidney function. The current study considers blood testican-2 levels among three cohorts of >8,000 individuals in total, including many with established kidney disease. Testican-2 levels are positively correlated with eGFR across the full range of kidney health, with higher levels associated with lower risk of incident end stage kidney disease (ESKD), even after adjusting for baseline eGFR, proteinuria, and other kidney disease risk factors. This study highlights a positive association between testican-2 and kidney health and prognosis.

Background
Testican-2 was recently identified as a podocyte-derived protein that is released into circulation by the kidneys and is positively correlated with eGFR and eGFR slope. However, whether higher testican-2 levels are associated with lower risk of ESKD is unknown.

Methods
Aptamer-based proteomics assessed blood testican-2 levels among participants in the African American Study of Kidney Disease and Hypertension (AASK, n=703), the Chronic Renal Insufficiency Cohort (CRIC) study (n=3196), and the Atherosclerosis Risk in Communities (ARIC) study (n=4378). We compared baseline characteristics by testican-2 tertile and used Cox proportional hazards models to study the association of testican-2 with incident ESKD.

Results
Higher testican-2 levels were associated with higher measured GFR (mGFR) in AASK, higher eGFR in the CRIC and ARIC studies, and lower albuminuria in all cohorts. Baseline testican-2 levels were significantly associated with incident ESKD in Cox proportional hazards models adjusted for age, sex, and race (model 1) and model 1+mGFR or eGFR+comorbidities (model 2). In model 3 (model 2+proteinuria), the associations between testican-2 (per SD increase) and incident ESKD were AASK (hazard ratio [HR]=0.84 [0.72 to 0.98], P=0.023), CRIC (HR=0.95 [0.89 to 1.02], P=0.14), ARIC (HR=0.54 [0.36 to 0.83], P=0.0044), and meta-analysis (HR=0.92 [0.86 to 0.98], P=0.0073).

Conclusions
Across three cohorts spanning >8000 individuals, testican-2 is associated with kidney health and prognosis, with higher levels associated with reduced risk of ESKD.
Analysis of Growth and Tourism Clusters in Madura
Authors: Mayvani Titov Chuk's , Afin Rifai , Idialis Alifah Rokhmah , Sariyani Sariyani 
Published: October 2022

The tourism sector is one of the essential sectors that drive economic growth. There are many tourist destinations in Madura Island that have uniqueness, where the tourism is based on beaches, culture, history, and even religion. However, the existence of tourist destinations has not been widely felt by the Madurese community economically. Therefore, tourism development in Madura needs attention, considering the tourism sector plays a vital role in encouraging economic growth. This research uses scalogram analysis and K-Means Clustering analysis. The scalogram analysis consists of Location Coefficient (LC) analysis which reflects the level of importance of a facility in an area, and functional index analysis, which is used to measure the hierarchy of facilities in each district or region. Meanwhile, the K-Means Clustering analysis is intended to see the Madura tourism clusters. This study indicates that Sumenep Regency can be the centre of tourism growth in attractions, amenities, and accessibility. The analysis shows that Sumenep Regency is the closest distance to the cluster centre or can be categorized as an advanced cluster. Then, Pamekasan Regency is a less developed cluster because it is far from the cluster centre. This research provides some recommendation in increasing economic growth in Madura.
Indonesia's Agriculture Tax: An Approach to the GTAP Model
Authors: Dewanti Diah Setyawati , Purna Fitra Prasapawidya 
Published: October 2022

Tax is a policy tool to control the market. As Indonesia implied an agriculture tax of about 10% in 2014, it is worthy of capturing how it affects the market. This paper aims to find the effect of the implied tax on the market by seeing the country's sales, demand, imports, exports, and welfare. The method used is GTAP model simulation with the base of GTAP9 and aggregated based on the case applied. The result shows that the tax implied makes the demand, import, and export decrease even for the country that implements it. However, the sale and welfare gained by the origin country are increasing. Even China, the United States, and Australia have difficulty dealing with the policy as their welfare decreases. This research tries to find the effect of the agriculture tax that Indonesia implied in 2014. Using GTAP model simulation reveals how the tax affects the sale, demand, import, export, and gain or loss of welfare country.
Sister Mary Joseph’s nodule from primary endometrial carcinoma: a case report
Authors: Ramanathan Annamalai , Nagandla Kavitha , Jamli Faiz 
Published: October 2022

Sister Mary Joseph’s nodule (SMJN) refers to umbilical metastases is rare and is likely be the first manifestation of an underlying malignancy likely gastrointestinal or genital in origin. The incidence reported is about 1-3% and has a poor prognosis with an overall survival (OS) of 2-11 months from the initial diagnosis. The ovarian location is incriminated the most common site followed by endometrium in gynaecological cancers. Only 32 cases of SMJN from endometrium with have been reported in the published literature. A 57-year-old postmenopausal woman, presented with a large bleeding and infected umbilical mass and symptomatic anaemia. A diagnosis of SMJN was made following biopsy of the mass which revealed metastasis of an endometrial adenocarcinoma. She underwent 6 cycles of neoadjuvant chemotherapy. Subsequent laparotomy including full resection of the umbilical lesion, abdominal wall reconstruction with composite mesh, and a total abdominal hysterectomy with bilateral salpingo-oophorectomy, omentectomy and bilateral lymph nodes excision. Histological diagnosis revealed metastasis from primary endometrial carcinoma. Currently patient condition is stable and is on follow up. This is the 33rd case as reported in the literature of SMJN originating from endometrial carcinoma from authors knowledge. Our approach was multimodal with neoadjuvant chemotherapy followed by surgery and adjuvant radiotherapy. Currently there is no specific recommendation and management should be individualised.
PELATIHAN DAN PENGEMBANGAN KEMAMPUAN WARGA KELURAHAN LAMARU DALAM MENGOLAH LIMBAH KOTORAN TERNAK MENJADI KOMPOS ORGANIK
Authors: Vicky Andria Kusuma  , Aji Akbar Firdaus  
Published: October 2022

Pupuk adalah suatu zat yang diberikan ke tanah untuk menyuburkan atau memperbaiki kondisi tanah. Pupuk secara umum dibagi menjadi 2 yaitu pupuk organic (kompos) dan anorganik). Kompos merupakan pupuk yang berasal dari bahan organic yang dibutuhkan oleh tanaman. Rukun Tetangga (RT) 13 Desa Lamaru merupakan salah satu unit tetangga yang diklasifikasikan sebagai Desa Tangguh oleh pemerintah. Sebagian besar warga RT. 13 bekerja sebagai peternak dan petani. Desa tersebut terdapat sumber daya yang dimiliki, seperti lahan yang digunakan warga untuk menanam sayur mayur sehingga dapat dikonsumsi dijual ke pasar. Selain itu, lumbung yang digunakan bersama oleh masyarakat untuk pakan ternak. Namun, beberapa sumber daya yang dimiliki warga belum dimanfaatkan secara optimal seperti kotoran sapi yang dapat dijadikan kompos. Ada juga alat pengasah yang terbengkalai dan disalahgunakan. Hal ini karena kurangnya pengetahuan dan kesadaran masyarakat tentang pupuk organik sehingga masyarakat tidak memanfaatkan sumber-sumber tersebut. Berdasarkan permasalahan tersebut, melalui pengabdian masyarakat ini dilakukan beberapa kegiatan untuk dapat menjawab permasalahan tersebut. Kami akan memberikan edukasi tentang manfaat kompos dan memberikan penyuluhan kepada warga tentang cara membuat kompos.
PENGEMBANGAN MANAJEMEN PELATIHAN SUMBER DAYA MANUSIA BERDASAR SISTEM ADDIE PADA APARATUR DI BADAN PENGEMBANGAN SDM PROVINSI JAWA TIMUR: DIGITALISASI TRAINING NEEDS
Authors: Jusuf Irianto  , Sulikah Asmorowati  , Yuniawan Heru Santoso  
Published: October 2022

Program Pengembangan Sumber Daya Manusia (SDM) sangat penting dalam meningkatkan kinerja aparatur dan mendukung organisasi mencapai tujuannya. Pengembangan SDM dilakukan dalam bentuk kegiatan pelatihan (training). Secara konseptual, training dilakukan berdasarkan model atau sistem ADDIE yaitu tahap-tahap Training Needs Analysis, Training Design, Training Program Development, Training Implementation, dan Training Evaluation. Pelaksanaan semua tahap pelatihan tersebut tidak lepas dari teknologi digital. Tujuan pengabdian kepada masyarakat ini adalah untuk mengembangkan aplikasi sebagai bagian dari teknologi digital untuk digunakan dalam penyusunan analisis kebutuhan pelatihan. Lokasi kegiatan adalah Badan Pengembangan Sumber Daya Manusia (BPSDM) Pemerintah Provinsi Jawa Timur yang selama ini belum sepenuhnya menggunakan teknologi digital termasuk dalam menganalisis kebutuhan pelatihan. Metode yang digunakan adalah ceramah tatap muka dan diskusi serta Focus Group Discussion (FGD) untuk menyepakati fitur-fitur (features) yang harus diakomodasi dalam aplikasi. Hasil pengabdian kepada masyarakat menunjukkan manfaat bagi BPSDM Jawa Timur dalam menyusun dan mengembangkan analisis kebutuhan pelatihan secara digital dan diperlukan kerja sama secara berkelanjutan untuk mendukung digitalisasi program pengembangan SDM aparatur.
How do grain coats prevent formation of quartz overgrowths?
Authors: Walderhaug Olav , Porten Kristin W. 
Published: October 2022

Abstract
Examination of grain coats of chlorite, illite, detrital clay, microquartz, and siderite in deeply buried sandstones from the Norwegian continental shelf by scanning electron microscopy shows that the quartz surfaces beneath the grain coats are covered by tiny quartz outgrowths bounded by planar crystal faces. These very small euhedral quartz outgrowths also occur in gaps in the coats where there is no physical barrier to impede their continued growth into adjacent macropores, but such outward growth and expansion into the intergranular pore space was observed only where the gaps in the coats are larger than around 5 μm. We suggest that the inability of euhedral quartz outgrowths smaller than a certain size to grow through grain coats and form large pore-filling quartz overgrowths is a consequence of the increased solubility of micron-sized crystals compared to larger crystals. Due to surface energy effects, the smallest crystals of a mineral are unable to grow at conditions that do not prevent growth of larger crystals of the same mineral. This is a general thermodynamic effect that becomes important for tiny crystals with a large surface-to-volume ratio and is expressed quantitatively by the Ostwald-Freundlich equation. The reason microscopic outgrowths can develop on the quartz grain surfaces in the first place is probably that the initial pre-euhedral growth stages are able to grow at slightly lower silica supersaturations than euhedral outgrowths. Continued growth at the low supersaturations prevalent in most sandstones may consequently depend upon the outgrowths reaching a euhedral shape after they are larger than a critical size. Outgrowths nucleated in gaps in the grain coats smaller than around 5 μm develop planar crystal faces before they have attained the critical size because there is not enough space for larger euhedral outgrowths to form in these smaller gaps. The outgrowths nucleated in the smallest openings are therefore unable to grow through the grain coats and reach the adjacent pore space despite free access to the adjacent macropores. Grain coats can therefore prevent quartz cementation without being continuous at the microscopic scale.