bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análisis de la minería informal en la economía peruana periodo 2018 al 2022
Authors: Munsibay-Muñoa Manuel Alberto , Cavero-Egúsquiza-Vargas Lauralinda Leonor 
Published: October 2022

El presente artículo tiene como objetivo analizar el impacto que causa la minería informal en lo económico, social y ambiental en el Perú del 2018 al 2022, la metodología utilizada es de tipo descriptivo con enfoque cualitativo, la técnica aplicada fue el análisis documental y el instrumento empleado fue la matriz de triangulación, que permitió recolectar y analizar los datos de artículos y documentos seleccionados obtenidos de la base de datos como Scopus, Web of science, Scielo, Redalyc y Proquest, abarcando temas relevantes sobre minería informal. Después de analizar la documentación se obtuvo como primer resultado que la minería informal impactó en la actividad económica, la recaudación tributaria y el nivel de empleo debido al proceso lento de formalización por parte del estado y como segundo resultado para inicios del 2022 se obtuvo que la expansión minera, como la minera artesanal, informal y la abiertamente ilegal cobró mayor importancia, sobre todo, la minería aurífera ocupando territorios e identificándose cuatro zonas con presencia de minería informal, como Puno, Madre de Dios, La libertad y el sur medio (Ica, Arequipa, y Ayacucho). Concluyéndose así, que el tema minero juega un rol importante en la economía peruana contribuyendo así con un 12% al PBI, un 60% de las exportaciones y 21% del stock de inversión extranjera directa, generando negocios y mayor empleo en la actividad comercial y por otro lado, los mercados financieros peruanos estuvieron dispuestos a respaldar grandes inversiones y reformas estructurales en la minería, haciendo que, la economía tenga un crecimiento económico sostenido durante las últimas décadas.
Subpopulation Composition of Peripheral Blood Lymphocytes and its Prognostic Significance in Children with Acquired Aplastic Anemia
Authors: Емельянова И.В. , Углова Т.А. , Быданов О.И. , Мовчан Л.В. 
Published: October 2022

Установлено, что 64-й и 180-й дни иммуносупрессивной терапии (ИСТ) у детей с приобретенной апластической анемией (ПАА) являются информационными точками ее эффективности. Достижение гематологического ответа (ГО) к 180-му дню ИСТ ассоциировано с долгосрочными результатами лечения.Выявлены изменения субпопуляционного состава лимфоцитов ПК у детей с ПАА: снижение инициального относительного содержания CD16+CD56+ лимфоцитов и CD19+ лимфоцитов (р<0,0001; р=0,0003 соответственно) и инициального содержания CD3+HLA-DR+ лимфоцитов и CD3+CD8+ лимфоцитов (р<0,0001; р<0,0001 соответственно) по сравнению с аналогичными показателями у детей группы контроля. Установлено, что уровень CD19+ лимфоцитов на 64-й день ИСТ позволяет прогнозировать ГО к 180-му дню проведения ИСТ.Выявлено увеличение бессобытийной выживаемости пациентов с тПАА, получивших ИСТ с дополнительным введением биомедицинского клеточного продукта мезенхимальных стволовых клеток (БМКП МСК).
The 64th and 180 days of immunosuppressive therapy (IST) in children with acquired aplastic anemia (AАА), are detremined to be information points of its effectiveness. The achievement of a hematological response (HR) by the 180th day of IST is associated with long-term treatment results.Changes in the subpopulation composition of peripheral blood lymphocytes (PВ) in children with АА were revealed: a decrease in the initial relative content of CD16+CD56+ lymphocytes and CD19+ lymphocytes (p<0.0001; p=0.0003, respectively) and an increase in the initial content of CD3+HLA-DR+lymphocytes and CD3+CD8+ lymphocytes (p<0.0001; p<0.0001, respectively) compared with similar indicators in children in the control group.It was found that the level of CD19+ lymphocytes on the 64th day of the IST allows predicting HR by the 180th day of the IST.An increase in the event-free survival of patients with sAAA who received IST with additional administration of a biomedical cellular product of mesenchymal stem cells (BMCP MSCs) was revealed.
New Translocation Established by NGS in Tumor Material from a Pediatric Patient with Alveolar Rhabdomyosarcoma
Authors: Белобокова В.Д. , Кальченко К.О. , Михалевская Т.М. , Кочубинский Д.В. , Белевцев М.В. , Киселев Л.П. 
Published: October 2022

Результаты современных исследований подтверждают необходимость точных молекулярных исследований мягкотканных новообразований. Высокопроизводительноесеквенирование следующего поколения может быть эффективным методом как для подбора таргетной терапии, так и для прогнозирования степени агрессивности биологического поведения опухоли. В данной работе описан случай альвеолярной рабдомиосаркомы у ребенка трехлетнего возраста. В ткани новообразования для данного пациента было проведено молекулярно-генетическое исследование методом высокопроизводительного секвенирования с применением панели генов TruSight™ Tumor 170 (Illumina, США). По результатам исследования была выявлена транслокация NSD1-FGFR4, ранее не описанная в литературе у пациентов с рабдомиосаркомой альвеолярного типа.
The results of modern research confirm the need for accurate molecular studies of soft tissue neoplasms. High-throughput next-generation sequencing can be an effective method for both selecting targeted therapy and predicting the degree of aggressiveness of the biological behavior of a tumor. This paper describes a case of alveolar rhabdomyosarcoma in a three-year-old child. In the tumor tissue for this patient, a molecular genetic study was performed using high-throughput sequencing using the TruSight™ Tumor 170 gene panel (Illumina, USA). The results of the study revealed a translocation of NSD1-FGFR4, which has not been previously described in the literature for patients with alveolar-type rhabdomyosarcoma.
Comparative analysis of the results of decompressive interventions in elderly patients with cauda equine syndrome caused by lumbar spinal stenosis
Authors: Бывальцев В.А. , Калинин А.А. , Шепелев В.В. , Пестряков Ю.Я. , Голобородько В.Ю. , Хозеев Д.В. , Сатардинова Э.Е. , Комогорцев И.Е. , Щеголев А.В. 
Published: October 2022

Цель исследования - оценка результатов хирургического лечения и эффективности клинического восстановления пациентов пожилого возраста с синдромом конского хвоста (СКХ), обусловленного дегенеративным стенозом позвоночного канала, после выполнения открытой и минимально-инвазивной декомпрессии. Проведен ретроспективный анализ послеоперационных исходов у 50 пациентов старше 60 лет, которым выполнены изолированные открытые ( n =21) и минимально-инвазивные ( n =29) декомпрессивные вмешательства по поводу СКХ, обусловленного стенозом позвоночного канала. Для сравнительной оценки использовали технические особенности вмешательства, специфичность послеоперационного ведения пациентов, клинические исходы и периоперационные осложнения. В результате установлены преимущества малотравматичной изолированной декомпрессии в сравнении с открытой по меньшему объему кровопотери и продолжительности госпитализации, низкой потребности пациентов в послеоперационном обезболивании, минимальному количеству периоперационных хирургических осложнений, динамике неврологической симптоматики, лучшему клиническому восстановлению функционального состояния по шкале ODI и качеству жизни по опроснику SF-36 в отдаленном послеоперационном периоде.
The aim of the study was to evaluate the results of surgical treatment and the effectiveness of clinical recovery in elderly patients with cauda equina syndrome (CES) caused by degenerative spinal canal stenosis after isolated open and minimally invasive decompression. A retrospective analysis of the results of surgical treatment of 50 patients over 60 years of age who underwent isolated open (n=21) and minimally invasive (n=29) decompressive interventions for CES caused by lumbar spinal stenosis was performed. For comparative analysis, we used the technical features of the intervention, the specificity of postoperative management of patients, clinical parameters, and the number of perioperative complications. As a result, the advantages of minimally invasive isolated decompression compared to open decompression due to a smaller volume of blood loss and duration of hospitalization, low need for postoperative pain relief, a minimum number of perioperative surgical complications, as well as the dynamics of neurological symptoms, better efficiency of clinical recovery of functional state indicators according to ODI and quality life according to SF-36 in the late postoperative period.
Restriction of breastfeeding in the early postnatal period leads to metabolic and endocrine disorders in eighteen-month-old male rats
Authors: Деркач К.В. , Бондарева В.М. , Шпаков А.О. 
Published: October 2022

Дефицит грудного вскармливания в раннем постнатальном периоде может приводить к метаболическим и гормональным нарушениям во взрослом возрасте. Однако исследования влияния голодания в раннем онтогенезе на метаболические и гормональные показатели у старых животных отсутствуют. Практически не изучено влияние такого голодания на функции эндокринной системы. Цель исследования - изучение того, как прерывание лактации у кормящих самок крыс (на 19-21-й день постнатального развития крысят) влияет на метаболические показатели, толерантность к глюкозе, чувствительность к инсулину и гормональный статус гонадной и тиреоидной осей у их потомства, 18-месячных самцов крыс. Ингибирование лактации вызывали с помощью обработки самок крыс бромокриптином (10 мг/кг в сутки). Показано, что старые самцы крыс с частичным лишением грудного вскармливания имеют характерные признаки метаболического синдрома - повышенную массу тела и жировой ткани, нарушенную толерантность к глюкозе, инсулиновую резистентность, гиперлептинемию. У них снижен уровень тестостерона и тиреоидных гормонов, повышен уровень ТТГ, снижены стероидогенный ответ на гонадолиберин и стимулирующий эффект тиролиберина на уровень тироксина. Таким образом, краткосрочная депривация грудного вскармливания, вызванная бромокриптин-индуцированным ингибированием лактации у кормящих самок, приводит к развитию метаболического синдрома и гормональной дисрегуляции репродуктивной и тиреоидной систем у 18-месячных самцов крыс.
Breastfeeding deficiency in the early postnatal period can lead to metabolic and hormonal disorders in adulthood. However, there are no studies on the effect of starvation in early ontogeny on metabolic and hormonal parameters in aging animals. The effect of such starvation on the functions of the endocrine system has not been practically studied. The aim of this work was to study how interruption of lactation in lactating female rats (19-21 days of postnatal development of rat pups) affects metabolic parameters, glucose tolerance, insulin sensitivity, and hormonal status of the gonadal and thyroid axes in their offspring, 18-month-old male rats. Inhibition of lactation was induced by treating female rats with bromocriptine (10 mg/kg/day). It has been shown that aging male rats with partial deprivation of breastfeeding have characteristic signs of the metabolic syndrome, such as the increased body weight and adipose tissue, impaired glucose tolerance, insulin resistance, and hyperleptinemia. They have reduced levels of testosterone and thyroid hormones, increased levels of thyroid-stimulating hormone, reduced steroidogenic response to gonadoliberin and a decrease in thyroliberin stimulating effect on thyroxine levels. Thus, short-term deprivation of breastfeeding caused by bromocriptine-induced inhibition of lactation in lactating females leads to the development of metabolic syndrome and hormonal dysregulation of the reproductive and thyroid systems in 18-month-old male rats.
Kesalahan dan Kesulitan Mahasiswa Pendidikan Matematika Unismuh dalam Menegasikan Definisi Limit Fungsi
Authors: Qadry Ikhbariaty Kautsar , Firdaus Andi Mulawakkan , M Muhammad Darwis , Asyari Syahrullah , Ramdani Rezki 
Published: October 2022

Penelitian ini adalah penelitian kualitatif yang bertujuan mengetahui kesalahan dan kesulitan mahasiswa pendidikan matematika Unismuh dalam menegasikan definisi limit fungsi. Subjek penelitian ini adalah dua orang berkemampuan logika matematika tinggi, mahasiswa Semester II Program Studi Pendidikan Matematika Unismuh Makassar. Penelitian ini menggunakan teknik triangulasi metodologi untuk mengecek keabsahan data, yaitu metode pemberian tes dan wawancara. Oleh karena itu, ada dua instrumen pendukung dalam penelitian ini, yaitu tes, berupa Tes Kemampuan Logika Matematika yang digunakan untuk menjaring subjek penelitian, dan Tes Kemampuan Menegasikan Definisi Limit Fungsi. Hasil penelitian menunjukkan bahwa dua subjek memiliki kesamaan dan perbedaan. Salah satunya mengalami semua jenis kesalahan dalam prosedur Newman, dan satu yang lain tidak mengalami Transformation Error saja. Kedua subjek penelitian mengalami kesulitan yang sama dalam menghadapi pernyataan berkuantor majemuk. Mereka kesulitan menjustifikasi kuantor dan maknanya, kesulitan menentukan fungsi pernyataannya, dan kesulitan menentukan bagian yang ingin dinegasikan. Kata kunci: kesalahan, kesulitan, negasi, definisi limit fungsi. This is a qualitative research aimedat uncovering the mistakes and difficulties of mathematics education students of Unismuh in negating the definition of limit of function. The research subjects were two students of the second semester of the mathematics education study program of Unismuh with high ability in mathematical logic. This study used a methodological triangulation technique to check the validity of the data. It was to provide the subjects with tests and interviews. There were two supporting instruments in this study, namely, a test such a mathematical logic ability test which was used to select the students to be the research subjects, and a test for investigating their ability to negate the definition of limit of function. The results show that the two subjects have similarities and differences. One of them experiences all the types of Newman errors, and the other one has no transformation error type only. The two subjects experience the same difficulty in dealing with statements with multiple quantifiers. They have difficulty in justifying the quantifier and its meaning. Also, difficulty in finding the function of the statement and justifying the part to negate. Keywords: error,difficulty, negation, definition of limit of function.
Analisis Kandungan Gizi Kopi Biji Salak Desa Pekkabata Kecamatan Duampanua Kabupaten Pinrang
Authors: Pratiwi Diana Eka , Putri Suriati Eka , Wardhana haeruddin Muhammad Ilham 
Published: October 2022

Analisis kandungan gizi kopi biji salak Desa Pekkabata Kecamatan Duampanua Kabupaten Pinrang bertujuan untuk mengetahui kandungan protein, kadar lemak, dan karbohidrat yang terkandung dalam kopi biji salak produk PKM Badan Kontak Majelis Taklim (BKMT) Desa Pekkabata. Berdasarkan hasil wawancara dan observasi dengan masyarakat setempat, salak hasil panen biasanya dijual ke pasar dan juga biasanya dikonsumsi sendiri, namun biji salak hanya dibuang begitu salak. Dengan demikian tim pengabdi melakukan penyuluhan mengenai pembuatan kopi bijisalak. Berdasarkan hasil analisis diperoleh kadar protein sebesar 4,42%; kadar lemak 12,19%; dan kadar karbohidrat 46,74%.Kata kunci: kopi, biji salak, kandungan gizi. The analysis of the nutritional content of salak seed coffee in Pekkabata Village, Duampanua District, Pinrang Regency aims to determine the protein content, fat content and carbohydrates contained in the zalacca seed coffee products of Community Partnership Program (PKM) BKMT Pekkabata Village. Based on the results of interviews and observations with the local community, the farmed salak is usually sold to the market and is also usually consumed alone, however the zalacca seeds are only thrown away. Thus the PKM team conducted counseling on the making of zalacca seed coffee. Based on the analysis results obtained protein content of 4.42%; fat content 12.19%; and carbohydrate content of 46.74%.Keywords: coffee, salak seed, nutritional content.
Peningkatan Kemampuan Representasi Matematis melalui Media Lipa’ Sa’be Mandar
Authors: Samad Irfawandi , Ahmad Herlina , Febryanti F. 
Published: October 2022

Penelitian ini bertujuan untuk meningkatkan kemampuan representasi matematis siswa di SMK Mega Link Majenemelalui media pembelajaran lipa’ sa’be Mandar.Jenis penelitian ini merupakan penelitian tindakan kelas yang dilaksanakan selama 2 siklus yang meliputi empat tahapan yaitu perencanaan, pelaksanaan observasi dan evaluasi serta refleksi.Teknik analisis menggunakan analisis statistika deskriptif. Hasil penelitian diperoleh nilai rata-rata kemampuan representasi matematis sebesar 82,65 dengan standar nilai KKM sebesar 70. Sedangkan nilai ketuntasan secara klasikal sebesar 84,21% dengan standar 80%. Aktivitas siswa dan keterlaksanaan guru dalam menerapkan pembelajaran melalui media lipa’ sa’be Mandar berada pada kategori terpenuhi.Berdasarkan hasil penelitian, maka disimpulkan penerapan media pembelajaran lipa’ sa’be Mandar mampu meningkatkan kemampuan representasi matematis siswa SMK Mega Link Majene.Kata kunci: Representasi Matematis, Media Pembelajaran, Lipa’ Sa’be Mandar This research aims to improve the ability of mathematical representation of the students in SMK Mega Link Majene through the media learning Lipa ' Sa'be Mandar. This type of research is a class action study conducted during 2 cycles that includes four phases, namely planning, observation and evaluation and reflection. Analytical techniques using descriptive statistical analysis. The results of the study obtained an average value of the mathematical representation capability of 82,65 with a standard KKM value of 70. Meanwhile, the classifications of the classic value of 84,21% with standard 80%. Student activity is in very active category. The implementation of researchers in applying learning through Media lipa ' sa'be Mandar well done. Based on the results of the research, it was concluded the application of learning Media lipa ' sa'be Mandar able to improve the mathematical representation capability of SMK Mega Link Majene.Keywords: Mathematical Representation, Media Learning, Lipa' Sa'be Mandar
Profil Sikap Ilmiah Siswa Kelas IV SD Inpres Ana Gowa dan SD Negeri Tombolo K
Authors: Rusni R. , Bahri Arsad , Ristiana Evi 
Published: October 2022

Penelitian ini bertujuan untuk mengetahui gambaran sikap ilmiah siswa kelas IV SD Inpres Ana Gowa dan SD Negeri Tombolo K. Penelitian ini adalah penelitian survei dengan analisis data menggunakan statistik deskriptif. Populasi dalam penelitian ini adalah seluruh siswa kelas IV SD Inpres Ana Gowa dan SD Negeri Tombolo K. Teknik sampling yang digunakan adalah simple random sampling. Sampel dalam penelitian ini adalah siswa kelas IVB dan IVC SD Inpres Ana Gowa dan siswa kelas IVA dan IVB SD Negeri Tombolo K dengan jumlah sampel 124 siswa. Teknik pengumpulan data menggunakan angket sikap ilmiah. Hasil penelitian menunjukkan bahwa sikap ilmiah siswa memiliki rerata skor realtif sama.Indikator sikap ilmiah yang memiliki rerata skor tertinggi adalah sikap mendahulukan data atau fakta dengan persentase 63,50% dan skor indikator sikap ilmiah terendah adalah sikap berpikir kritis dengan persentase 62,20%. Hal ini menunjukkan sikap ilmiah siswa masih perlu dikembangkan dalam proses pembelajaran agar berpengaruh terhadap hasil belajar kognitif dan utamanya hasil belajar afektif dalam pembelajaran IPA. Kata kunci: Sikap ilimiah, hasil belajar IPA afektif This study aims to determine the description of scientific attitudes of fourth grade students of SD Inpres Ana Gowa and SD Negeri Buttono K. This research is a survey research with data analysis using descriptive statistics. The population in this study were all fourth grade students of Ana Gowa Inpres Elementary School and SD Negeri Buttono K. The sampling technique used was simple random sampling. The sample in this study were students of class IVB and IVC of SD Inpres Ana Gowa and students of class IVA and IVB of SD Negeri Tombolo K with a total sample of 124 students. Data collection techniques using a scientific attitude questionnaire. The results showed that students' scientific attitudes had the same average score. The indicators of scientific attitudes that had the highest average scores were attitudes prioritizing data or facts with a percentage of 63.50% and the lowest scientific attitude indicator scores were critical thinking attitudes with a percentage of 62.20%. This shows that students' scientific attitudes still need to be developed in the learning process so that it affects cognitive learning outcomes and especially affective learning outcomes in science learning. Keywords: Scientific attitudes, affective learning outcomes
Laju Pengurangan Kadar Vitamin C Selama Penyimpanan Buah Naga (Hyloceres Undatus)
Authors: Asmawati A. , Karim Abd. , Iman Ilham Nur 
Published: October 2022

Penelitian ini bertujuan untuk mengetahui laju pengurangan kadar vitamin C selama penyimpanan buah naga putih (Hylocereus Undatus). Eksperimen ini dilakukan dengan mengetahui besarnya penurunan kadar vitamin C selama penyimpanan buah naga putih dengan metode iodimetri (titrasi langsung). Hasil penelitian menunjukkan kadar vitamin C buah naga putih pada hari ke 5 adalah 29,406 mg/100 gram, pada hari ke 10 adalah 26,591 mg/100 gram, pada hari ke 15 adalah 19,594 mg/100 gram, pada hari ke 20 adalah 16,847 mg/100 gram, pada hari ke 25 adalah13,157mg/100 gram. Berdasarkan kadar vitamin C tersebut, maka diperoleh persamaan garis dengan nilai dan membuktikan kadar vitamin C buah naga putih adalah orde satu.Kata kunci: Laju pengurangan, Buah naga putih, Iodometri This study aims to determine levels of vitamin C and white dragon fruit (Hylocereus Undatus). The experiment was conducted with the determination of vitamin C with iodimetric method (direct titration). The results showed levels of vitamin C and white dragon fruit on day 5 is 29.406, on day 10 was 26.591, on day 15 is 19.594, on day 20 is 16.847, on day 25 is 13.157. Based on the levels of vitamin C, then obtained a reduction rate of 0.4385 x 10-1 which proved levels of vitamin C and white dragon fruit is first order.Keywords: The rate of reduction, white dragon fruit (Hylocereusundatus), iodometry