bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowing and Not Knowing
Authors: Ray Sangeeta 
Published: October 2022

AbstractThis article articulates how an epistemology of ignorance structures the postcolonial metropolitan critic’s knowledge about a particular fraught state in India, Assam. Using the term agnotology, coined by Robert Proctor, rather than agniology, it examines two novels, Missing by Bengali writer Sumana Roy and The House with a Thousand Stories by Assamese novelist and poet Aruni Kashyap, to show that, despite their crucial differences in form, style, and narration, both novels use a locally inflected English language to tell stories about how rumor and gossip destroy families and communities living in the shadow of insurgencies and state violence. The Anglophone metropolitan postcolonial critic’s often-shallow knowledge about a region, its literature and deep politics, and their many rationalizations about why it is so, dovetails with the manner in which lies, exaggerated and fake news, shape and produce what counts as knowledge in these Indian Anglophone novels. Both works evoke the failure of a poetics and politics of familial and extrafamilial relations to underline how death and the disappearance of women from families, from society, and from the news enable a comparison of the inventive engagements with gender to understand the relationship of ignorance to truth.
Northeast Indian or Assamese
Authors: Kashyap Aruni 
Published: October 2022

Abstract
What does it mean to be a writer from Northeast India? What does it mean to write from the margins of India? What are the limitations of Indian English writing when it comes to depicting marginal, radical literary traditions that question the idea of India? The author of The House with a Thousand Stories and There Is No Good Time for Bad News, Aruni Kashyap, shares his formative experiences as a writer, including the influences of Indian writers such as Amitav Ghosh, Assamese literary culture, and Indigenous oral storytelling traditions.
Shedding of ciliary vesicles at a glance
Authors: Ojeda Naharros Irene , Nachury Maxence V. 
Published: October 2022

ABSTRACTCilia sense and transduce sensory stimuli, homeostatic cues and developmental signals by orchestrating signaling reactions. Extracellular vesicles (EVs) that bud from the ciliary membrane have well-studied roles in the disposal of excess ciliary material, most dramatically exemplified by the shedding of micrometer-sized blocks by photoreceptors. Shedding of EVs by cilia also affords cells with a powerful means to shorten cilia. Finally, cilium-derived EVs may enable cell–cell communication in a variety of organisms, ranging from single-cell parasites and algae to nematodes and vertebrates. Mechanistic understanding of EV shedding by cilia is an active area of study, and future progress may open the door to testing the function of ciliary EV shedding in physiological contexts. In this Cell Science at a Glance and the accompanying poster, we discuss the molecular mechanisms that drive the shedding of ciliary material into the extracellular space, the consequences of shedding for the donor cell and the possible roles that ciliary EVs may have in cell non-autonomous contexts.
Differential Expression in the Tumor Microenvironment of mRNAs Closely Associated with Colorectal Cancer Metastasis
Authors: Ito Kazuhiro , Osakabe Mitsumasa , Sugimoto Ryo , Yamada Shun , Sato Ayaka , Uesugi Noriyuki , Yanagawa Naoki , Suzuki Hiromu , Sugai Tamotsu 
Published: October 2022

Abstract
Background
Metastasis of colorectal cancer (CRC) is a major cause of CRC-related mortality. However, the detailed molecular mechanism of CRC metastasis remains unknown. A recent study showed that the tumor microenvironment, which includes cancer cells and the surrounding stromal cells, plays a major role in tumor invasion and metastasis. Identification of altered messenger RNA (mRNA) expression in the tumor microenvironment is essential to elucidation of the mechanisms responsible for tumor progression. This study investigated the mRNA expression of genes closely associated with metastatic CRC compared with non-metastatic CRC.

Methods
The samples examined were divided into cancer tissue and isolated cancer stromal tissue. The study examined altered mRNA expression in the cancer tissues using The Cancer Genome Atlas (TCGA) (377cases) and in 17 stromal tissues obtained from our laboratory via stromal isolation using an array-based analysis. In addition, 259 patients with CRC were enrolled to identify the association of the candidate markers identified with the prognosis of patients with stage 2 or 3 CRC. The study examined the enriched pathways identified by gene set enrichment analysis (GSEA) based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) module in both the TCGA dataset and isolated stromal tissue.

Results
As a result, whereas tenascin-C, secreted phosphoprotein 1 and laminin were expressed in metastatic CRC cells, olfactory receptors (ORs) 11H1 and OR11H4 were expressed in stromal tissue cells isolated from metastatic CRC cases. Finally, upregulated expression of tenascin-C and OR11H4 was correlated with the outcome for CRC patients.

Conclusion
The authors suggest that upregulated expression levels of tenascin-C and OR11H1 play an important role in CRC progression.
Molecular Dynamics Simulation of the Antigen–Antibody Complex Formation Process between Hen Egg-White Lysozyme and HyHEL-10
Authors: Takamatsu Yuichiro , Hamakubo Takao , Yamashita Takefumi 
Published: October 2022

Abstract
We performed molecular dynamics (MD) simulations (57 µs in total) to examine the formation of a typical antigen–antibody complex, that of hen egg-white lysozyme (HEL) and its antibody, HyHEL-10. We observed that HEL and HyHEL-10 successfully formed native complexes in several MD simulations. Energetic analyses showed that native complexes tend to have lower interaction energies than most of the other encounter complexes, which is a useful feature for computational complex structure prediction. In the stabilization process, we found that the N32L residue underwent a characteristic conformational change (structural locking), which significantly enhanced the interaction energy. In addition, we performed MD simulations for the N32LD mutein. The results showed that the N32LD mutation enhanced the electrostatic interaction and accelerated the encounter dynamics. However, in the stabilization process, the N32LD mutation deteriorated the structural locking role of N32L, and therefore we could not find any specific conformational change to stabilize the complex structure. The resultant loose feature of the N32LD complex is consistent with experimental observations that the N32LD mutation decreases binding affinity but leads to a large entropic gain.
Enhancement of Dielectric Breakdown Strength and Its Possible Mechanism in Triple-Layered Films Formed by Stacking Resin Layers with Different Relative Dielectric Constants
Authors: Inagaki Yumi , Kozawa Takahiro , Yano Kazuhisa , Nakamura Tadashi 
Published: October 2022

Abstract
Dielectric properties of co-extruded triple-layered films consisting of polymethyl methacrylate (PMMA) sandwiched between polyvinylidene fluoride (PVDF) layers were evaluated. The triple-layered films showed a higher dielectric breakdown strength and a higher energy density than each single-layer film, and the enhancement depended on the volume ratio of the PMMA layer, which has a lower relative dielectric constant than PVDF. The simulation of dielectric breakdown paths using the phase-field model revealed that the middle layer with a lower dielectric constant shares a higher voltage until its dielectric breakdown, resulting in an enhancement of the dielectric breakdown strength in the triple-layered film. The simulation results well matched the experimental data, indicating that controlling the volume ratio and relative dielectric constant of each layer in the triple-layered film is an effective approach to enhancing dielectric breakdown strength. This concept is considered promising for developing dielectric materials that enable a size reduction of film capacitors.
Perceived Benefits and Barriers to Physical Activity among LGBTQ+ College Students
Authors: Frederick Ginny M. , Bub Kristen L. , Evans Ellen M. 
Published: October 2022

ABSTRACT

Introduction/Purpose
Members of the lesbian, gay, bisexual, transgender, and queer (LGBTQ+) community experience health disparities in part due to health behaviors, including physical activity (PA). This cross-sectional study explored perceived benefits and barriers to PA, an important health behavior for both physical and mental health, among LGBTQ+ college students using quantitative and qualitative methods.

Methods
College students identifying as LGBTQ+ (n = 47) were assessed for PA via accelerometry and completed the Exercise Benefits and Barriers Scale (EBBS). Six focus groups (4–8 participants each) provided qualitative descriptions of perceived benefits and barriers to PA.

Results
PA guidelines (aerobic and resistance training) were met by ~30% of participants. Qualitative descriptions aligned with EBBS subscales of general benefits and barriers to PA. General minority stress, perceived stigma, internalized homophobia, and discrimination and violence emerged as themes related to the experienced barriers. Furthermore, effects of PA on body shape, focus on aesthetics in the LGBTQ+ community, the importance of physically active LGBTQ+ role models, deviance from social or gender norms related to PA, and same-sex relationships and body image were additional concerns related to LGBTQ+ identity.

Conclusions
Qualitative responses indicate that LGBTQ+ college students perceive general benefits and barriers to PA. Barriers to engaging in sufficient PA due to minority stress and concerns related to identity as LGBTQ+ were evident. These findings can be used to develop tailored health promotion programs on college campuses to address the barriers to PA faced by LGBTQ+ students. More research is needed in the college-aged LGBTQ+ community to build robust PA health promotion efforts to enhance inclusivity and reduce health disparities.
Go Wide or Go Deep? Assortment Strategy and Order Fulfillment in Online Retail
Authors: Gopalakrishnan Sanjith , Matta Moksh , Yourdshahy Mona Imanpoor , Choudhary Vivek 
Published: October 2022

Problem definition: Expansions in product assortment by online retailers often engender operational challenges. In undertaking such expansions, retailers exercise a strategic choice between expanding assortment width or depth. Our understanding of how this choice affects the order fulfillment process is limited. Thus, we examine the impact of these dimensions of assortment strategy on order delivery timeliness. Academic/practical relevance: Order delivery timeliness is a critical measure of operational success in online retail. We contribute to theory and practice by adopting a multidimensional perspective of retailer assortment strategy and studying the relative impact of assortment width and depth on order delivery timeliness. Methodology: Employing a data set comprising more than 200 million orders, we study the effects of assortment strategy on delivery timeliness using an instrumental variable approach. We then utilize a two-stage model to estimate the impact of delivery performance on sales. Further, we employ a matched difference-in-differences and a novel Bayesian structural time-series model to confirm this relationship. Results: We find that assortment width has a greater negative impact on order delivery timeliness compared with assortment depth. A one-standard-deviation increase in assortment width increases average delivery times by 0.55 days. Further, we find this effect to be positively moderated (i.e., worsened) by the average size of orders and to be negatively moderated (i.e., improved) by the logistic service provider’s (LSP) experience. Finally, a one-day increase in delivery times for 10% of the orders results in a 2.7% reduction in sales. Managerial implications: Our findings suggest that online retailers focused on ensuring timely deliveries should be wary of widening product assortments, especially when facing larger average order sizes. We also find that experienced logistic service providers can help mitigate the dilatory effects of assortment width expansions. However, the benefits of experienced LSPs are limited for retailers deepening their assortments.History: This paper has been accepted as part of the 2018 MSOM Data Driven Research Challenge.Supplemental Material: The online appendices are available at https://doi.org/10.1287/msom.2022.1156 .
Factors influencing the use of aquatic therapy: perspectives from occupational therapists
Authors: Young Sarah , Collins Tracy 
Published: October 2022

Background/Aims Aquatic therapy has been identified as more conducive than land-based treatment options to improve health and quality of life in some patient populations. However, the prevalence of occupational therapists who implement aquatic therapy in practice is low. The aim of this study was to understand the perceptions of barriers and facilitators to aquatic therapy use by occupational therapists in the USA. Methods Individual semi-structured interviews were completed (via Skype) with four occupational therapists who held an ‘aquatic therapeutic exercise certificate’ from the Aquatic Therapy and Rehab Institute. Interviews were audio recorded and manually transcribed verbatim. Inductive thematic analysis was employed to identify themes and sub-themes in the data. Results The following three overarching themes were identified: institutional constraints and resources impact aquatic therapy implementation; the perceived lack of unity within the occupational and aquatic therapy communities; and implications of aquatic therapy's low prevalence within the occupational therapy profession. Conclusions Institutional factors including pool accessibility, insurance coverage, and employer support are determinants of practitioners' abilities to use aquatic therapy. The research identified a desire for support through networking and the need to build the authority of occupational therapists in aquatic therapy to offset the barriers implicated with being a minority profession.
A qualitative study of illness narratives: ‘overcoming the monster’ master plot for patients with stroke
Authors: Alawafi Rana , Rosewilliam Sheeba , Soundy Andrew 
Published: October 2022

Background/Aims Research that considers illness narrative ‘master plots’ (common and recognisable story plots related to the experience of illness), as expressed by individuals who have had a stroke, is needed Thus far, the literature has focused on identifying pre-established illness narrative master plots: the restitution, the chaos and the quest narrative. However, these narrative plots represent extreme psychological responses to the experience of illness; other narratives need to be understood in order to most effectively support individuals with stroke. Further research must identify if other master plots exist, and consider the implication of such plots. Methods A narrative methodology was undertaken, contextualised within a social constructivist worldview. A purposive sample of individuals with stroke undertook a single online semi-structured interview. A categorical-form narrative analysis was undertaken in five stages. Results A total of eight individuals were interviewed. Following analysis, six individuals were identified as illustrating experiences related to a master plot termed ‘overcoming the monster’. The ‘monster’ was represented in several ways, which included: a mental health problem or an expression relating to internal feelings; a sense of being isolated from others; a threat to the individual's independence; and a negative interaction or experience related to health care. Individuals identified clear strategies for ‘overcoming the monster’. These included: adopting a different way of viewing life; identifying and attaining both big and small goals; persistence and determination in the face of adversity; and giving support to others through activities and receiving support. Conclusions Allied health professionals need to understand the importance of this narrativisation of stroke because research has shown that allied health professionals can stereotype interactions by plots and seek to correct them. Implications of these findings ilustate the importance of understanding the individuals experience, not immediately reacting to a narrative type that may seem to fit, understanding the plot of overcoming the monster varies and may need time to be observed.
Wear Behavior between a Jujube Branch and a Hammer Claw of a Jujube Branch Crusher
Authors: Ding Longpeng , Li Jingbin , Kan Za , Lei Shibo , Li Ning , Ren Hao 
Published: October 2022

HighlightsThe wear behavior between the metal and the nonmetal was discussed.The wear characteristics between jujube branches and hammer claws at different sliding speeds were studied.The effects of the morphology of jujube branches and debris on wear behavior were analyzed.Abstract.A jujube branches crusher can effectively solve the difficult processing problem of the abandoned jujube branches, but the hammer claw, a key part in the crusher, often breaks due to wear. Studying the wear resistance of the hammer claw under different rotating speeds can improve the service life of the jujube branches crusher. The factors affecting the wear characteristics of the hammer claw were studied by means of scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). Wear tests and theoretical calculations showed that the friction coefficient between the hammer claw and the jujube branches tended to decrease as the speed increased, and the friction coefficient was the lowest at 45 m/min. There are two reasons for this phenomenon. The first reason is that the physical characteristics of jujube branches lead to a decrease in the friction coefficient. Second, with increasing speed, the friction coefficient of the contact surface will be further reduced by the lamellar-type debris of the jujube branches and spherical debris of the hammer claw. This work should be able to provide an experimental and theoretical basis for the selection of the rotation speed of a jujube branches crusher under actual working conditions. Keywords: Characterization, Hammer claw, Jujube branches, Sliding speed, Wear.
Designing Arduino Instruction for Novice Agriculture Students: Effects on Interest, Self-efficacy, and Knowledge
Authors: Johnson Donald M. , Pate Michael Lynn , Estepp Christopher M. , Wardlow George W. , Hood Grant T. 
Published: October 2022

HighlightsAn instructional treatment for teaching novice Arduino users was developed, tested, refined, and found to be effective.The revised instructional treatment significantly increased novice users’ interest, knowledge, self-efficacy, and skills in using Arduinos.Incorporation of small ‘practice activities’ during the lesson portion of the instructional treatment was proven effective.The results support the use of the program evaluation model and self-efficacy theory as effective frameworks for instructional development. Abstract. This study employed the program evaluation model and self-efficacy theory to develop, evaluate, revise, and re-evaluate an instructional treatment (lesson and hands-on activity) intended to increase the interest, self-efficacy, and knowledge of novice Arduino users in two colleges of agriculture. Arduino is a line of programmable, open-source microcontrollers widely used in education and research. Program evaluation provides an iterative model of instructional development where the results of a pilot-test are used to guide refinement of instruction and materials which are reevaluated in subsequent test(s). Self-efficacy theory posits that positive mastery, vicarious, and social persuasion experiences lead to increased confidence in task performance and subject matter interest. In the pilot-test study at University A (n = 27), the initial instructional treatment resulted in significant (p &lt; 0.05) and large increases in students’ breadboarding self-efficacy and Arduino knowledge, but not in programming self-efficacy or interest in learning about Arduino. After revising the instructional treatment to include four hands-on tasks as part of the lesson, the re-test study at University B (n = 20) resulted in significant (p &lt; 0.05) and large increases in students’ interest in learning about Arduino, breadboarding self-efficacy, programming self-efficacy, and Arduino knowledge. The results of this study indicated the utility of program evaluation as a curriculum development model and the efficacy of incorporating small hands-on activities into lessons for novices learning new technical skills. Finally, use of self-efficacy theory as a framework for curriculum development was validated. Keywords: Arduino, Microcontrollers, Novice programmers, Program evaluation model, Self-efficacy theory, Teaching.
Broadband gain performance in the mid-IR using supercontinuum: 2.7  µm gain in high-purity Er3+doped tungsten tellurite glass fibers
Authors: Muraviev S. V. , Dorofeev V. V. , Motorin S. E. , Koptev M. Yu. , Kim A. V. 
Published: October 2022

This paper presents an experimental study of broadband mid-IR
amplification that is carried out, for the first time, to the best of
our knowledge, in an erbium-doped tungsten tellurite fiber. A simple,
robust supercontinuum source based on a tapered germanate fiber is
developed as a seed input in the region of 1.5–3 µm. We show
that gain by a factor of 5 on one pass can be achieved in the
2.7 µm range by pumping a low-cost, high-efficiency diode laser
at 976 nm using high-purity tellurite glass fibers.
Constructing, validating, and updating machine learning models to predict survival in children with Ebola Virus Disease
Authors: Genisca Alicia E. , Butler Kelsey , Gainey Monique , Chu Tzu-Chun , Huang Lawrence , Mbong Eta N. , Kennedy Stephen B. , Laghari Razia , Nganga Fiston , Muhayangabo Rigobert F. , Vaishnav Himanshu , Perera Shiromi M. , Adeniji Moyinoluwa , Levine Adam C. , Michelow Ian C. , Colubri Andrés 
Published: October 2022

Background
Ebola Virus Disease (EVD) causes high case fatality rates (CFRs) in young children, yet there are limited data focusing on predicting mortality in pediatric patients. Here we present machine learning-derived prognostic models to predict clinical outcomes in children infected with Ebola virus.

Methods
Using retrospective data from the Ebola Data Platform, we investigated children with EVD from the West African EVD outbreak in 2014–2016. Elastic net regularization was used to create a prognostic model for EVD mortality. In addition to external validation with data from the 2018–2020 EVD epidemic in the Democratic Republic of the Congo (DRC), we updated the model using selected serum biomarkers.

Findings
Pediatric EVD mortality was significantly associated with younger age, lower PCR cycle threshold (Ct) values, unexplained bleeding, respiratory distress, bone/muscle pain, anorexia, dysphagia, and diarrhea. These variables were combined to develop the newly described EVD Prognosis in Children (EPiC) predictive model. The area under the receiver operating characteristic curve (AUC) for EPiC was 0.77 (95% CI: 0.74–0.81) in the West Africa derivation dataset and 0.76 (95% CI: 0.64–0.88) in the DRC validation dataset. Updating the model with peak aspartate aminotransferase (AST) or creatinine kinase (CK) measured within the first 48 hours after admission increased the AUC to 0.90 (0.77–1.00) and 0.87 (0.74–1.00), respectively.

Conclusion
The novel EPiC prognostic model that incorporates clinical information and commonly used biochemical tests, such as AST and CK, can be used to predict mortality in children with EVD.