bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early urate-lowering therapy in gouty arthritis with acute flares: a double-blind placebo controlled clinical trial
Authors: Yang Deng-Ho , Chen Hsiang-Cheng , Wei James Cheng-Chung 
Published: August 2022

Abstract
Background
Gouty arthritis (GA) is a chronic systemic disease with recurrent acute monoarthritis. In a previous study, a higher incidence of acute flares was observed during the initial marked decrease in serum urate level. Our study evaluated the effect of early urate-lowering therapy in patients with acute GA flares.
Methods
This study included 40 patients with acute GA; of them, 20 received colchicine 0.5 mg colchicine twice daily, while 20 received probenecid 500 mg and colchicine 0.5 mg twice daily. We evaluated GA severity and laboratory data for two weeks after the initial therapy.
Results
Rapidly decreasing serum uric acid levels was found in the patients treated with probenecid and colchicine compared with the patients treated with colchicine alone on day 8 (-1.77 ± 2.037 vs 1.24 ± 2.084; P < 0.0001). However, the mean decrease in visual analog scale score did not differ significantly between the two groups (-5.20 ± 3.09 vs -3.63 ± 2.38; P = 0.079).
Conclusion
No significant increase was noted in acute gout flare severity or duration among GA patients treated with early aggressive control of hyperuricemia using probenecid plus colchicine.
Leisure time activities in adolescents predicts problematic technology use
Authors: Ibabe Izaskun , Albertos Aranzazu , Burgo Cristina López-del 
Published: August 2022

Abstract
Introduction. The problematic use of technology of children and adolescents is becoming a growing problem. Research has shown that excessive technology use predict a variety of psychological and physical health problems. The aim of this study was to analyze the role of leisure time activities (structured and unstructured) in adolescents as a predictor of problematic technology use. Method. Participants were 7,723 adolescents of which 55% were girls from four Spanish-speaking countries (Chile, Spain, Mexico, and Peru) between the ages of 13 and 18 years. The evaluation instrument applied was the YOURLIFE project self-report questionnaire. Two executive functions were measured: goal setting and inhibitory control. Results. Using structural equation modeling, findings indicated that structured leisure time activities predicted less PTU, whereas unstructured activities predicted more PTU, MLχ2 (69, N = 7,723) = 806.60; CFI= .929, RMSEA= .042, and the model had good predictive capacity for PTU (R2 = .46). Structured and unstructured activities also showed indirect effects on PTU through executive functions. Conclusions. As adolescents spent more time in unstructured leisure activities, poorer goal setting, inhibitory control skills, and more PTU were found. The opposite was right for structured leisure time activities. Implications of structured leisure activities to develop executive functioning and to prevent PTU for adolescents are discussed.
E - RiCoBiT – II : A High Performing RiCoBiT (Ring Connected Binary Tree) Topology With Fully Adaptive Routing Algorithm
Authors: Sanju V , Manvi Sunilkumar 
Published: August 2022

Abstract
Network on Chip (NoC) is very useful in connecting the different components of a chip. Many NoC topologies like 2D mesh, torus etc. are already in use. RiCoBiT (Ring Connected Binary Tree) is a new topology which was recently proposed and studied. RiCoBiT is a topol-ogy where performance parameters like maximum hop and average hop are better than the other topologies. Area parameters like wire-length and number of wire segments are approximately the same as compared to other topologies, but one of the biggest problems with this topology was the lack of an adaptive routing algorithm. Thus, we propose a new routing algorithm which is adaptive in nature. The algorithm is tested for all cases: destination and source in the same ring, destination is above the source ring, and the destination is below the source ring. The testing of the algorithm was performed by using a simulation setup for E-RiCoBiT-II (Enhanced RiCoBiT). It is observed that the topology is 100The average hop, maximum hop, and total time are studied for the proposed architecture and algorithm.
A Novel Image Encryption Algorithm Based on Double Permutation and Random Diffusion
Authors: Zheng Jiming , xue mingkun 
Published: August 2022

Abstract
To improve the image transmission security, an image encryption algorithm based on double permutation with random diffusion is proposed in this paper. This algorithm consists of three stages: adaptive key generation, double scrambling and random diffusion. Firstly, in order to make the key highly correlated with the plaintext image, we use the SHA-256 value of the plaintext image to generate the key. Then, the double permutation is mainly composed of pixel-level permutation and bit-level permutation. The pixel-level permutation uses chaotic sequences generated by the chaotic system to generate the permutation sequences and uses these two sequences to rearrange the row and column coordinates of the image. Secondly, we implement bit-level permutation using the Fisher-Yates Shuffle algorithm as a group of every four neighboring pixels. The double permutation breaks the high correlation between image pixels. Thirdly, in the diffusion stage, we propose a random diffusion algorithm to address the problem that the diffusion order and direction of current diffusion methods are fixed and not random. The permuted image is divided into four blocks, and the order and direction of the diffusion operation for each pixel in each block is determined according to the chaotic sequence from the chaotic system. Finally, experimental results and security analysis show that the algorithm has good performance and sufficient security. It can resist a variety of attacks, such as statistical attacks, brute force attacks, and plaintext/selective plaintext attacks.
Molecular genetic identification of Opisthorchiidae cercariae from Bithyniidae snails of Chany Lake (South-Western Siberia, Russia)
Authors: Katokhin Aleksei V. , Serbina Elena A. 
Published: August 2022

Abstract

The studies of the opisthorchiids larval stages associated with Вithyniidae snails can provide the important and the most reliable data for opisthorchiidoses foci characterization due to the least mobility of the snails among opisthorchiids host species. Since the foci of opisthorchiosis (caused by Opisthorchis felineus) and metorchiosis (caused by Metorchis bilis) are overlapping in the basins of the Ob and Irtysh rivers the obstacles in determining the species of cercariae significantly reduce the accuracy of epidemiological conclusions regarding opisthorchiosis, which has a much higher medical significance. Moreover, the difficulties with identification are complicated by the fact that the focus of metorchiosis caused by Metorchis xanthosomus infecting birds of prey occur in the same territory. In this study we for the first time carried out the molecular genetic identification of West-Siberian opisthorchiid cercariae to verify morphological identification and confirmed O. felineus main association with Bithynia troschelii snail and M. bilis ‒ with B. tentaculata snail. Thus, our study applied an integrated approach combining first the morphological identification of opisthorchiid cercariae in Bithynia snails with subsequent molecular genetic identification of the cercarial samples.
Facilitators and barriers impacting in-hospital Trauma Quality Improvement Program (TQIP) implementation: A scoping review on the implementation of TQIPs across income levels
Authors: Kapanadze George , Berg Johanna , Sun Yue , Wärnberg Martin Gerdin 
Published: August 2022

Abstract
Background
Trauma describes physical injury along with the bodies associate reponse, and is a leading cause of mortality and morbidity globally, with low and middle income countries (LMICs) disproportionately affected. Understanding the implementation of in-hospital Trauma Quality Improvement Programs (TQIPs) and the factors determining success is critical to reduce the global trauma burden. The purpose of the review was to identify key facilitators and barriers to TQIP implementation across income levels by evaluating the range of literature on the topic.
Methods
We used information sources PubMed, Web of Science, and Global Index Medicus. The eligibility criteria was English language studies, of any design, published from June 2009 - January 2022. The Preferred Reporting Items of Systematic Reviews and Meta-Analyses checklist extension for scoping reviews were used to carry out a three-stage screening process. Content analysis using the Consolidated Framework for Implementation Research (CFIR) identified facilitator and barrier themes for in-hospital TQIP implementation.
Results
Twenty-eight studies met the eligibility criteria from 3923 studies. The main facilitators and barriers identified were the need to prioritise staff education and training, strengthen dialogue with stakeholders, and provide standardised best-practice guidelines. Data quality improvements were more apparent in LMICs while high-income countries (HICs) emphasised increased communication training.
Conclusions
Stakeholder prioritisation of in-hospital TQIPs, along with increased knowledge and consensus on trauma care best practice will further advance efforts to lower the global trauma burden. The focus of future in-hospital TQIPs in LMICs should primarily be concerned with improving data quality of registries, while interventions in HICs should focus on communication skills of healthcare professionals.
Identification of MTHFD1L as a potential biomarker for multiple cancers by pan-cancer analysis
Authors: Yan Lin , Wang Xin , Yang Jian-ming 
Published: August 2022

AbstractMTHFD1L is a monofunctional enzyme, which plays a vital role in the generation of tetrahydrofolate and maintains the balance of folate cycle. In the past ten years, it was reported that MTHFD1L may participate the growth and development of cancers. HPA (Human Protein Atlas) database was used to explored the consensus MTHFD1L tissues expression and MTHFD1L gene conservation analysis. The expression of MTHFD1L in different cancer types and the relationship between the level of expression of MTHFD1L and the cancer-associated fibroblast immune infiltration were showed in the TIMER2 database. Kaplan–Meier (K-M) analysis was performed to explore prognostic value of MTHFD1L in different cancers. The cBioPortal was used to investigate the MTHFD1L genetic mutation in various tumor types of TCGA. Finally, MTHFD1L-related genes enrichment analysis was performed to study the functional mechanism of MTHFD1L in carcinogenesis. In most cancers, the mRNA expression of MTHFD1L is higher in the tumor tissues compared to the normal tissues. Besides, higher expressions of MTHFD1L were significantly associated with shorter OS in ACC, BLCA, BRCA, CESC, HNSC, LGG, LIHC, LUAD, SKCM and shorter DFS in ACC, BLCA, CESC, LGG, PRAD and SKCM. The high expression of MTHDF1L was related to the advanced stage of BLCA, LIHC, LUAD, OV, SKCM, UCEC and UCS significantly. What’s more, MTHDF1L expression was positively linked with cancer-associated fibroblast infiltration in HNSC, KIRC, KIRP, LUAD and PAAD. The GO biological process (BP) enrichment includes mitotic cell cycle, cell cycle, mitotic cell cycle process and so on. MTHDF1L physically interacts with CLPP, CS, LRPPRC and MTIF2. This pan-cancer investigation suggested the prognostic value and oncogenic role of MTHFD1L for multiple tumor types.
A novel incision technique of totally implanted venous access port in upper arm for patients with breast cancer
Authors: Song Xue , Chen Shengying , Dai Yan , Sun Yang , Lin Xiaojie , He Jiafa , Chen Qianjun , Xu Rui 
Published: August 2022

Abstract
Background: Totally implanted venous access port (TIVAP) in upper arm is a safe and cost-effective vascular access device and is widely used in breast cancer patients. Traditional tunnel needle technique increase the operation time and unsatisfied cosmetic effect so we explore the feasibility, cosmetic effect, and complications of an upper arm port with an novel incision in this retrospective study.Methods: We reviewed 489 cases of totally implantable venous access port implantation in the upper arm with two types of incision in our center from 1 January 2018 to 30 January 2022. The patients were divided in to two different incision groups including puncture site incision group(n=282) and conventional tunnel needle group(n=207). The operation time,aesthetic appearance and complications were collected between the two groups and contributing factors were analyzed for major complications. Results: A total of 489 patients were successfully implanted arm port with puncture site incision technique(n=282, 57.7%) and conventional tunnel needle technique(n=207, 42.3%) . The average operation time of two types of incision was (36.5±115) min in the puncture site incision group and (55±18.1) min in the tunnel needle group ( P<0.05) . In terms of complications,33 catheter-related complications occurred (6.4%), including 9 cases of infection, 15 cases of catheter-related thrombosis and 7 cases of skin exposure. 14 patients in the puncture site incision group developed complications compared with 17 in the traditional incision group.There were no significant differences between the two groups in terms of overall complication events (5.0% and 8.2%, p=0.145) while the same result were found in each complication event.Weight, total cholesterol and diabetes were found to be associated with device-related infections in univariate Cox proportional hazard regression models. Diabetes was found to be associated with device-related infections in multivariate analysis while hypertension was associated with thrombosis.Conclusions: The methods of puncture site incision improves the efficiency of the procedure and provide a better cosmetic appearance compared with traditional tunnel needle technique. It is a novel technique and preferable for totally implantable venous access port implantation in upper arm with comparable overall rate of complication for patients with breast cancer. It is worthy of being used and promoted in clinical research.
Simple application of gout guidelines enables disease control: an observational study in French referral centres
Authors: Jauffret Charlotte , Ottaviani Sébastien , Latourte Augustin , Ea Hang-Korng , Graf Sahara , Lioté Frédéric , Bardin Thomas , Richette Pascal , Pascart Tristan 
Published: August 2022

Abstract
BackgroundRecent studies have shown a lack of implementation of gout recommendations in primary care. In this context of therapeutic inertia, the French Society of Rheumatology (SFR) published its first recommendations on gout in 2020, which were deliberately simple and concise. ObjectivesThe objectives were to determine the profile of patients referred to French gout expert centres, and to examine the results of their management and the factors leading to those results. MethodsThree hundred patients attending a first visit for gout management in three French referral centres were retrospectively and randomly included in this multicentre observational study.Visits were performed at baseline (M0) and scheduled for month 6 (M6), month 12 (M12), and month 24 (M24). Data collected included: patient profile; disease activity and treatments; serum urate (SU) level; estimated glomerular filtration rate (eGFR). ResultsPatients were 81% male and mean age 62.2 ± 15.2 years. Only 15,3% of them had difficult-to-treat gout at baseline. Management followed French recommendations after the baseline visit in 94.9% of cases. SU levels were below 6.0mg/dL in 59.4% of patients at M6, 67.9% at M12, and 78.6% at M24, with increasing clinical improvement (i.e. flare decrease) over 2 years of follow-up. At M24, 50% of patients were treated with allopurinol (313 ± 105 mg/d), which exceeded renal restrictions of doses in 61.5% of them, and 48.2% received febuxostat (84 ± 36mg/d). The need for a sufficient dosage of ULT was the only predictive factor found for successful reach SU levels <6.0mg/dL at a given visit. Overall, 50 patients (16.7%) received off-label anakinra for flare treatment or flare prophylaxis. ConclusionSimple application of gout management guidelines is feasible in clinical practice, and is efficient with a majority of patients achieving SU targets and clinical improvement.
How to build a novel burst disease diagnostics for hunting potential infection source: the enlightenment from screening patients via combining viral and antibody testing at the COVID-19 pandemic early stage
Authors: Chen Yu-Yan , Tong Man-Li , Zhang Hui-Lin , Liu Li-Li , Yang Tian-Ci , Lin Li-Rong 
Published: August 2022

Abstract
Purpose: We aimed to summarize the diagnostic strategies used to identify potential patients with COVID-19 among inbound overseas travelers in Xiamen, China.Methods: From October 2020 to December 2020, 180,000 inbound overseas travelers were subjected to government quarantine in Xiamen, China. We evaluated the screening efficiency of combining viral and antibody testing strategies to identify potential patients with COVID-19. Results: The COVID-19 positive rate was 0.17% (306/180,000). There was no difference between the combined PCR and antibody and the PCR testing strategy for screening COVID-19(2.0 [IQR,2.0–3.0] vs. 2.0[IQR,2.0–2.0]; P= 0.175). The results for the combined screening strategy were available 4 days earlier than those for the PCR testing strategy (3.0 [IQR, 3.0–3.0] vs. 7.0[IQR, 7.0–14.0], P=0.000). Compared with the non-key screening population, the key screening population showed less PCR rounds (2.0 [IQR, 2.0–2.0] vs. 2.0[IQR, 2.0–3.0]; (P=0.008) and time (3.0[IQR, 3.0–3.0] vs. 7.0[IQR, 7.0–14.0]; P=0.000) for screening COVID-19. Conclusion: Combining viral and antibody testing strategies is effective; it allows timely identification of the source of COVID-19 infection. Moreover, this strategy can be used for close contacts or sub-close contacts of patients with COVID-19 to reduce the risk of SARS-CoV-2 transmission.
An equation for determining the beta Euler shape exponents of plant growth data – a program toolbox for plant physiologists
Authors: Kosek Jerzy , Pietruszka Mariusz 
Published: August 2022

Abstract
Since the almost simultaneous appearance of the acid growth homeostasis approach in plant physiology and the increased availability of mainframe computers in the mid-20th century, there had been an amplified need to quantitatively predict the plant cell critical parameters during growth. Here, we provide a ready-to-use computer program, using an original numerical method, solving a highly nonlinear equation that is based on the formalism published in [J Plant Growth Regul (2020) 39:841–866], which can be used directly for this purpose. In this method article, the standalone program is written in a Python-based open source scientific software environment (e.g., CoCalc) in order to determine these cardinal traits and facilitate its use without any barriers to readers. It can be used to determine growth of an elongating individual plant cell or multicellular organs (coleoptile or hypocotyl segment) at the non-meristematic limit. The low number of relevant parameters (two) and the inclusion of the quantities that are decisive for growth such as pH and temperature make this program a practical set of tools for comparing growth-related experimental data in various areas of plant biology. It can also be widely used to predict plant growth during the process of assisted migration at a time in which the Earth is facing climate change.
Quantifying the temporal dynamics of the protective effect of forests against rockfall after disturbances
Authors: Moos Christine , May Dominik , Dorren Luuk , Temperli Christian , Schwarz Massimiliano 
Published: August 2022

Abstract
Increasing disturbances may significantly impact the long-term protective effect of forests against natural hazards. Quantifying the temporal evolution of the protection service of forests after disturbances is thus crucial for finding optimal management strategies. In this study, we quantified the long-term protective effect of spruce, beech and fir forests against rockfall after severe disturbances based on a straightforward modeling approach. We therefore modelled stand growth of the three tree species based on data of the Swiss National Forest Inventory (NFI) and parameterized the potential rockfall energy dissipation capacity of these stands as a function of their age. We then quantified the evolution of their protective effect for varying rockfall dispositions. The recovery of the protective effect mainly depends on the increase in basal area of a stand, the block volume and the forested slope length. While maximum protection against small blocks is guaranteed after only 10 to 50 yr, 50-150 yr are necessary to regain the maximum possible protective effect against blocks $\ge 1$ m\textsuperscript{3}. The here presented approach can serve practitioners to forecast the recovery of the protection provided by forest stands. As a next step, the proposed model should be adapted to future climate conditions.
Lack of association of Vascular Risk Factors with HIV-associated neurocognitive disorders in cART-treated adults aged ≥50 years in Tanzania
Authors: Flack Katherine , Rainey Emma , Urasa Sarah , Koipapi Sengua , Kalaria Raj , Howlett William , Mukaetova-Ladinska Elizabeta , Dekker Marieke , Gray William Keith , Walker Richard , Dotchin Catherine , Mtwaitele Himidi , Lewis Thomas , Stone Lydia , McNally Richard , Makupa Philip , Paddick Stella-Maria 
Published: August 2022

Abstract
Objectives: HIV-associated neurocognitive disorders (HAND) are highly prevalent in those ageing with treated HIV. High-income country data suggest that vascular risk factors (VRFs) may be stronger predictors of HAND than HIV-disease severity. This hypothesis is yet to be examined in the population ageing with HIV in sub-Saharan Africa. Our aim was to evaluate relationships of VRFs, vascular end organ damage and HAND in individuals aged ≥50 receiving HIV treatment in TanzaniaDesign: Cross sectional observational study, with systematic sampling.Methods: c-ART-treated individuals were assessed for HAND by consensus criteria. Prevalence of VRFs (hypertension, hypercholesterolemia, obesity, diabetes, and smoking) and end organ damage markers (prior myocardial infarction, stroke, left ventricular hypertrophy, estimated-glomerular filtration rate, ankle-brachial pressure index, retinal arteriovenous ratio) were measured. Independent associations of VRFs, end organ damage and HAND were examined by multivariable logistic regression.Results: Data were available for 153 individuals (median age 56, 67.3% female). HAND was highly prevalent (66.7%, 25.5% symptomatic) despite well-managed HIV (70.5% virally suppressed). Vascular risk factors included hypertension (34%), obesity (10.5%), hypercholesterolemia (33.3%), diabetes (5.3%) and current smoking (4.6%). End organ damage prevalence ranged from 1.3% (prior MI) to 12.5% (LVH). Measured VRFs and end organ damage were not independently associated with HAND, although there was a significant association with lower diastolic BP (p 0.030, OR 0.969 (0.943-0.997).Conclusion: The overall lack of association between vascular risk factors, vascular end organ damage and HAND suggests vascular risk factors are not major drivers of HAND in this setting. Further studies should explore alternative aetiologies such as chronic inflammation.