bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Sensationalism Affect Executive Compensation? Evidence from Pay Ratio Disclosure Reform
Authors: CHANG WONJAE , DAMBRA MICHAEL , SCHONBERGER BRYCE , SUK INHO 
Published: July 2022

ABSTRACTBeginning in 2018, U.S. public firms were required to report the ratio of the chief executive officer's (CEO) compensation to their median employee's compensation in the annual proxy statement. Exploiting the staggered reporting of pay ratios, we find little evidence that total CEO compensation changes in response to pay ratio disclosure reform. However, we do find that boards significantly adjust the mix of compensation awarded by reducing the sensitivity of CEO pay to equity price changes, particularly when the CEO is likely to garner media scrutiny, and by reducing reliance on stock‐based and other compensation components that are most susceptible to media coverage surrounding the pay ratio disclosure. Firms ultimately disclosing higher pay ratios garner more media coverage around the filing of their proxy statement, and more negative‐toned coverage in the subsequent month. Finally, we find evidence that greater pay disparity is associated with greater selling activity by retail investors and more negative say‐on‐pay votes following pay ratio reform, consistent with a broad set of investors responding to public scrutiny resulting from pay ratio disclosures.
Promoting pro‐environmental behavior through organizational identity and green organizational climate
Authors: Zafar Hina , Ho Jo Ann , Cheah Jun‐Hwa , Mohamed Rosmah 
Published: July 2022

This study was conducted to explore the influence of green human resource practices on employees' voluntary pro‐environmental behavior through the sequential mediation path of green organizational climate and organizational identity. A total of 459 employees from the textile industry in Pakistan participated in the study. The results were collected using two sources (managers and employees) at two time points. The proposed research model of the study was tested using structural equation modeling. The results validated the significant positive relationship between green organizational climate and organizational identity. We also found support for the serial mediation of green organizational climate and organizational identity in the green human resource management–voluntary pro‐environmental behavior relationship. All the hypotheses were significant. Overall, this study explains why and how green human resource management practices lead to voluntary pro‐environmental behavior. The implications for theory and practices that will enable organizations to encourage voluntary pro‐environmental behavior among their employees are discussed.
Role of milk and milk products in the spread of methicillin‐resistant Staphylococcus aureus in the dairy production chain
Authors: Titouche Yacine , Akkou Madjid , Houali Karim , Auvray Frédéric , Hennekinne Jacques‐Antoine 
Published: July 2022

AbstractMilk and milk products can harbor a multiple varieties of microorganisms. Therefore, they can be an important source of foodborne pathogens, including multidrug‐resistant bacteria. Methicillin‐resistant Staphylococcus aureus (MRSA) causes a wide spectrum of infections both in animals and humans. Over the last two decades, the presence of MRSA in foods and food‐producing animals, including milk and milk products, has been frequently reported worldwide, raising public health concerns. In order to monitor and prevent foodborne MRSA contamination, it is necessary to understand their sources, the pheno/genotypic characteristics of the strains, and their transmission dynamics. In this review, studies conducted worldwide were summarized in order to assess the prevalence and diversity of MRSA circulating in milk and milk products. The risk factors for the occurrence of MRSA in milk and milk products were also discussed with preventive and control measures to avoid MRSA contamination in the dairy food chain.
Non‐radiographic axial spondyloarthritis in South America. Burden of disease and differential features with respect to ankylosing spondylitis at time of diagnosis. A comprehensive analysis with a focus on images
Authors: Garcia Salinas Rodrigo , Jaldin Cespedes Rosario , Gomez Ramiro Adrian , Aguerre Dario , Sommerfleck Fernando 
Published: July 2022

AbstractBackgroundNon‐radiographic axial spondyloarthritis (nr‐axSpA) data from South America are scarce, especially regarding image features.ObjectiveTo estimate the frequency of nr‐axSpA and ankylosing spondylitis (AS) in a cohort of Argentinian patients with chronic low back pain (LBP) and to analyze the difference between both, with focus on magnetic resonance imaging (MRI) lesions, at diagnosis.MethodsPatients with LBP and a diagnosis of axSpA who participated in a reuma‐check program were included. All patients with a suspicion of SpA were evaluated using blood analytics, HLA‐B27, and images (MRI). Sociodemographic data, SpA features, diagnostic dela,y and clinimetrics were assessed by an operator who was blinded to the patient’s test results. On MRI, the presence of SpA lesions was assessed and a concordance exercise was carried out between rheumatologists and radiologist.ResultOf 198 LBP patients, 97 had axSpA, 54% of whom were nr‐axSpA. A positive MRI was found in 50%. No difference in terms of disease activity, functional impact, laboratory or treatments between nr‐axSpA and AS were found. Higher frequencies of male sex and chronic lesions on sacroiliac MRI were found in AS patients. In the logistic regression, an independent association with AS diagnosis was found: male (odds ratio [OR] 4.8), MRI fat replacement (OR 4.6), MRI sclerosis (OR 7.6), and diagnostic delay of more than 2 years (OR 10). The concordance between rheumatologists and radiologists was considered good to very good (κ 0.7‐0.8).ConclusionThe frequency of nr‐axSpA was 54%. We found a higher frequency of being male, more SpA features, and a longer diagnostic delay in patients with AS. Patients with AS had more structural lesions, with a good concordance between rheumatologist and radiologist.
Update on pathomechanisms and treatments in allergic rhinitis
Authors: Zhang Yuan , Lan Feng , Zhang Luo 
Published: July 2022

AbstractAllergic rhinitis (AR) is a global health problem with increasing prevalence and association with an enormous medical and socioeconomic burden. New recognition of immune cells such as type 2 innate lymphocytes (ILC2s), T helper (Th2) 2 cells, follicular helper T cells, follicular regulatory T cells, regulatory T cells, B cells, dendritic cells, and epithelial cells in AR pathogenesis has been updated in this review paper. An in‐depth understanding of the mechanisms underlying AR will aid the identification of biomarkers associated with disease and ultimately provide valuable parameters critical to guide personalized targeted therapy. As the only etiological treatment option for AR, allergen‐specific immunotherapy (AIT) has attracted increasing attention, with evidence for effectiveness of AIT recently demonstrated in several randomized controlled trials and long‐term real‐life studies. The exploration of biologics as therapeutic options has only involved anti‐IgE and anti‐type 2 inflammatory agents; however, the cost‐effectiveness of these agents remains to be elucidated precisely. In the midst of the currently on‐going COVID‐19 pandemic, a global life‐threatening disease, although some studies have indicated that AR is not a risk factor for severity and mortality of COVID‐19, this needs to be confirmed in multi‐centre, real‐life studies of AR patients from different parts of the world.
The effects of aerobic exercise combined with resistance training on inflammatory factors and heart rate variability in middle‐aged and elderly women with type 2 diabetes mellitus
Authors: Su Xiaoyun , He Jiping , Cui Jianmei , Li Hongmei , Men Jie 
Published: July 2022

AbstractObjectiveThis study investigated the effects of aerobic exercise combined with resistance training on serum inflammatory factors and heart rate variability (HRV) in women with type 2 diabetes mellitus (T2DM).MethodsA total of 30 patients with diabetic cardiovascular autonomic neuropathy (DCAN) were randomly divided into a control group (n = 15) and an exercise group (n = 15). The control group was treated with routine hypoglycemic drugs, while the exercise group was treated with routine hypoglycemic drugs + resistance training (AE + RT). The levels of fasting plasma glucose (FBG), two‐hour plasma glucose (2hPG), serum inflammatory factors C‐reactive protein (CRP), interleukin‐6 (IL‐6) and tumor necrosis factor alpha (TNF‐α) were measured before and after the intervention. The HRV was evaluated by 24‐h ambulatory electrocardiogram.ResultsAfter the intervention, the levels of FBG, 2hPG, serum inflammatory factors, IL‐6 and TNF‐α in the exercise group were significantly lower than those in the control group (p < .05) with no significant differences in serum CRP (p > .05). After the intervention, the HRV time domain and frequency domain indexes in the two groups were significantly improved compared with those before the exercise experiment (p < .01) and with no significant difference in (lnlf) (p > .05). The time‐domain indexes, i.e., SDNN and RMSSD, as well as the frequency domain index, i.e., (lnhf), were significantly higher in the exercise group than in the control group, whereas lnlf/lnhf were significantly lower than those in the control group (p < .05).ConclusionsCompared with routine hypoglycemic drug therapy, combining aerobic exercise and resistance training helped to reduce the level of blood glucose and serum inflammatory factors in T2DM patients with DCAN, and improved autonomic nerve function.
Reported congenital malformations after exposure to non‐tumour necrosis factor inhibitor biologics: A retrospective comparative study in EudraVigilance
Authors: Ghalandari Nafise , Crijns Hubertina J. M. J. , Bergman Jorieke E. H. , Dolhain Radboud J. E. M. , van Puijenbroek Eugène P. , Hazes Johanna M. W. 
Published: July 2022

AimsTo evaluate the number and nature of reported congenital malformations (CMs) after intrauterine exposure to non‐tumour necrosis factor inhibitor biologics (non‐TNFi biologics) compared to certolizumab pegol (CZP).MethodsA retrospective comparative study was conducted in the EudraVigilance (EV) database. A safe biologic (CZP) was considered as the reference group. Odds ratios (ORs) for CMs were calculated for each non‐TNFi biologic (including abatacept, anakinra, belimumab, ixekizumab, rituximab, secukinumab, tocilizumab, ustekinumab and vedolizumab), versus CZP (quantitative assessment). Then, CM patterns were reviewed in consultation with a clinical geneticist (qualitative assessment).ResultsORs were not statistically significant except for belimumab and vedolizumab (similar in magnitude). Except for vedolizumab, no specific CM patterns were observed for the included non‐TNFi biologics. Three cases of corpus callosum agenesis (CCA) were identified for vedolizumab (versus none in CZP and other investigated non‐TNFi biologics). Two of the CCA cases were associated with other neurological CMs (one cerebral ventriculomegaly with microcephaly and one polymicrogyria). This may indicate that these CCAs are related to undiagnosed genetic alterations or are associated with the underlying maternal disease, although a definite relationship with vedolizumab exposure cannot be ruled out.ConclusionNo special safety signal was identified regarding the occurrence of CMs after exposure to abatacept (n = 64), anakinra (n = 20), belimumab (n = 93), ixekizumab (n = 29), rituximab (n = 57), secukinumab (n = 128), tocilizumab (n = 124) and ustekinumab (n = 215). Regarding observed CCAs in the vedolizumab group (n = 113), no firm conclusions can be made based on available information.
Russian adolescent mental health in 2002, 2015 and during the COVID‐19 pandemic in 2021
Authors: Slobodskaya Helena R. , Safronova Margarita V. , Kharchenko Irina I. , Rezun Ekaterina V. , Kornienko Olga S. 
Published: July 2022

BackgroundAdolescent mental health is a global concern, however, time trends and the COVID‐19‐related restrictions vary across countries. This study examined changes in adolescent mental health and substance use in Russia between 2002, 2015 and during the pandemic in 2021.MethodsCross‐sectional school‐based surveys of 12‐ to 18‐year‐olds were carried out in a Siberian city in 2002 (N = 713), 2015 (N = 840) and 2021 (N = 721) using the Strengths and Difficulties Questionnaire, data on tobacco, alcohol and drug use and socio‐demographic information. We examined the effect of cohort, gender, family composition and parental occupation on mental health and substance use.ResultsThere were increases in emotional symptoms and internalising problems (B = 0.93, p < .001) and decreases in substance use over 19 years (B = ‐.73, p < .001). Changes in adolescent mental health and substance use were substantial from 2002 to 2015 and nonsignificant from 2015 to 2021. Increases in mental health problems were evident only among girls; a decrease in alcohol use was larger among boys. Family composition and parental occupation did not account for these changes.ConclusionsThese results suggest that the mental health of Russian adolescent girls has worsened in the 21st century; the gender gap in mental health has widened; the gender gap in alcohol use was reversed in 2021. The findings highlight the need for research into gender‐specific factors and for effective interventions. The lack of changes in Russian adolescent mental health and substance use from 2015 to during the pandemic in 2021 suggests successful coping; however, more research is needed.
Identification of novel rare copy number variants associated with sporadic tetralogy of Fallot and clinical implications
Authors: He Guo‐Wei , Maslen Cheryl L. , Chen Huan‐Xin , Hou Hai‐Tao , Bai Xiao‐Yan , Wang Xiu‐Li , Liu Xiao‐Cheng , Lu Wan‐Li , Chen Xin‐Xin , Chen Wei‐Dan , Xing Quan‐Sheng , Wu Qin , Wang Jun , Yang Qin 
Published: July 2022

AbstractTetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Highly penetrant copy number variants (CNVs) and genes related to the etiology of TOF likely exist with differences among populations. We aimed to identify CNV contributions to sporadic TOF cases in Han Chinese. Genomic DNA was extracted from peripheral blood in 605 subjects (303 sporadic TOF and 302 unaffected Han Chinese [Control] from cardiac centers in China) and analyzed by genome‐wide association study (GWAS). The GWAS results were compared with existing Database of Genetic Variants. These CNVs were further validated by qPCR. Bioinformatics analyses were performed with protein–protein interaction (PPI) network and KEGG pathway enrichment. Across all chromosomes 119 novel “TOF‐specific CNVs” were identified with prevalence of CNVs of 21.5% in chromosomes 1‐20 and 37.0% including Chr21/22. In chromosomes 1‐20, CNVs on 11q25 (encompasses genes ACAD8, B3GAT1, GLB1L2, GLB1L3, IGSF9B, JAM3, LOC100128239, LOC283177, MIR4697, MIR4697HG, NCAPD3, OPCML, SPATA19, THYN1, and VPS26B) and 14q32.33 (encompasses genes THYN1, OPCML, and NCAPD3) encompass genes most likely to be associated with TOF. Specific CNVs found on the chromosome 21 (6.3%) and 22(11.9%) were also identified in details. PPI network analysis identified the genes covering the specific CNVs related to TOF and the signaling pathways. This study for first time identified novel TOF‐specific CNVs in the Han Chinese with higher frequency than in Caucasians and with 11q25 and 14q32.33 not reported in TOF of Caucasians. These novel CNVs identify new candidate genes for TOF and provide new insights into genetic basis of TOF.
A prediction model integrating synchronization biomarkers and clinical features to identify responders to vagus nerve stimulation among pediatric patients with drug‐resistant epilepsy
Authors: Ma Jiayi , Wang Zhiyan , Cheng Tungyang , Hu Yingbing , Qin Xiaoya , Wang Wen , Yu Guojing , Liu Qingzhu , Ji Taoyun , Xie Han , Zha Daqi , Wang Shuang , Yang Zhixian , Liu Xiaoyan , Cai Lixin , Jiang Yuwu , Hao Hongwei , Wang Jing , Li Luming , Wu Ye 
Published: July 2022

AbstractAimsVagus nerve stimulation (VNS) is a neuromodulation therapy for children with drug‐resistant epilepsy (DRE). The efficacy of VNS is heterogeneous. A prediction model is needed to predict the efficacy before implantation.MethodsWe collected data from children with DRE who underwent VNS implantation and received regular programming for at least 1 year. Preoperative clinical information and scalp video electroencephalography (EEG) were available in 88 children. Synchronization features, including phase lag index (PLI), weighted phase lag index (wPLI), and phase‐locking value (PLV), were compared between responders and non‐responders. We further adapted a support vector machine (SVM) classifier selected from 25 clinical and 18 synchronization features to build a prediction model for efficacy in a discovery cohort (n = 70) and was tested in an independent validation cohort (n = 18).ResultsIn the discovery cohort, the average interictal awake PLI in the high beta band was significantly higher in responders than non‐responders (p < 0.05). The SVM classifier generated from integrating both clinical and synchronization features had the best prediction efficacy, demonstrating an accuracy of 75.7%, precision of 80.8% and area under the receiver operating characteristic (AUC) of 0.766 on 10‐fold cross‐validation. In the validation cohort, the prediction model demonstrated an accuracy of 61.1%.ConclusionThis study established the first prediction model integrating clinical and baseline synchronization features for preoperative VNS responder screening among children with DRE. With further optimization of the model, we hope to provide an effective and convenient method for identifying responders before VNS implantation.
Changes in OCT4 expression play a crucial role in the lineage specification and proliferation of preimplantation porcine blastocysts
Authors: Lee Mingyun , Oh Jong‐Nam , Choe Gyung Cheol , Kim Seung‐Hun , Choi Kwang‐Hwan , Lee Dong‐Kyung , Jeong Jinsol , Lee Chang‐Kyu 
Published: July 2022

AbstractObjectivesCuriosity about the role of OCT4, a core transcription factor that maintains inner cell mass (ICM) formation during preimplantation embryogenesis and the pluripotent state in embryonic development, has long been an issue. OCT4 has a species‐specific expression pattern in mammalian preimplantation embryogenesis and is known to play an essential role in ICM formation. However, there is a need to study new roles for OCT4‐related pluripotency networks and second‐cell fate decisions.Materials and MethodsTo determine the functions of OCT4 in lineage specification and embryo proliferation, loss‐ and gain‐of–function studies were performed on porcine parthenotes using microinjection. Then, we performed immunocytochemistry and quantitative real‐time polymerase chain reaction (PCR) to examine the association of OCT4 with other lineage markers and its effect on downstream genes.ResultsIn OCT4‐targeted late blastocysts, SOX2, NANOG, and SOX17 positive cells were decreased, and the total cell number of blastocysts was also decreased. According to real‐time PCR analysis, NANOG, SOX17, and CDK4 were decreased in OCT4‐targeted blastocysts, but trophoblast‐related genes were increased. In OCT4‐overexpressing blastocysts, SOX2 and NANOG positive cells increased, while SOX17 positive cells decreased, and while total cell number of blastocysts increased. As a result of real‐time PCR analysis, the expression of SOX2, NANOG, and CDK4 was increased, but the expression of SOX17 was decreased.ConclusionTaken together, our results demonstrated that OCT4 leads pluripotency in porcine blastocysts and also plays an important role in ICM formation, secondary cell fate decision, and cell proliferation.
Road mitigation structures reduce the number of reported wildlife‐vehicle collisions in the Bow Valley, Alberta, Canada
Authors: Edwards Hannah A. , Lebeuf‐Taylor Eleonore , Busana Michela , Paczkowski John 
Published: July 2022

AbstractHuman population and economic growth have resulted in roads transecting much of the North American landscape and this has negatively affected wildlife populations by fragmenting habitat, impeding movement between populations and increasing the chance of wildlife‐vehicle collisions. A common conservation tool to counteract these effects is the incorporation of road mitigation structures (RMS, i.e., jumpouts and overpasses/underpasses/fencing) into highway systems. However, gaps remain in our knowledge on RMS efficacy due to a lack of long‐term multispecies studies that can assess temporal and species‐specific variation in use. We investigate the efficacy of the Alberta Environment and Parks and Alberta Transportation RMS on the Trans‐Canada Highway (TCH) in the Bow Valley by analyzing annual reported wildlife‐vehicle collisions over a 23‐year period and wildlife use of the underpasses over a ten‐year period. We found that the incorporation of multiple underpasses and jumpouts, along with fencing, reduced the number of reported wildlife‐vehicle collisions on the TCH. We also found that wildlife use of the RMS exhibited variation with regards to month and location. Overall, our results add to the research supporting RMS effectiveness and suggest that incorporating additional similar infrastructure has the potential to further reduce wildlife‐vehicle collisions on the TCH.
Pharmacogenetics of taxane‐induced neurotoxicity in breast cancer: Systematic review and meta‐analysis
Authors: Guijosa Alberto , Freyria Ana , Espinosa‐Fernandez Jose Rodrigo , Estrada‐Mena Francisco J. , Armenta‐Quiroga Ana Sofía , Ortega‐Treviño Maria Fernanda , Catalán Rodrigo , Antonio‐Aguirre Bani , Villarreal‐Garza Cynthia , Perez‐Ortiz Andric C. 
Published: July 2022

AbstractTaxane‐based chemotherapy regimens are used as first‐line treatment for breast cancer. Neurotoxicity, mainly taxane‐induced peripheral neuropathy (TIPN), remains the most important dose‐limiting adverse event. Multiple genes may be associated with TIPN; however, the strength and direction of the association remain unclear. For this reason, we systematically reviewed observational studies of TIPN pharmacogenetic markers in breast cancer treatment. We conducted a systematic search of terms alluding to breast cancer, genetic markers, taxanes, and neurotoxicity in Ovid, ProQuest, PubMed, Scopus, Virtual Health, and Web of Science. We assessed the quality of evidence and bias profile. We extracted relevant variables and effect measures. Whenever possible, we performed random‐effects gene meta‐analyses and examined interstudy heterogeneity with meta‐regression models and subgroup analyses. This study follows the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) and STrengthening the REporting of Genetic Association Studies (STREGA) reporting guidance. A total of 42 studies with 19,431 participants were included. These evaluated 262 single‐nucleotide polymorphisms (SNPs) across 121 genes. We conducted meta‐analyses on 23 genes with 60 SNPs (19 studies and 6246 participants). Thirteen individual SNPs (ABCB1‐rs2032582, ABCB1‐rs3213619, BCL6/‐rs1903216, /CAND1‐rs17781082, CYP1B1‐rs1056836, CYP2C8‐rs10509681, CYP2C8‐rs11572080, EPHA5‐rs7349683, EPHA6‐rs301927, FZD3‐rs7001034, GSTP1‐rs1138272, TUBB2A‐rs9501929, and XKR4‐rs4737264) and the overall SNPs' effect in four genes (CYP3A4, EphA5, GSTP1, and SLCO1B1) were statistically significantly associated with TIPN through meta‐analysis. In conclusion, through systematic review and meta‐analysis, we found that polymorphisms, and particularly 13 SNPs, are associated with TIPN, suggesting that genetics does play a role in interindividual predisposition. Further studies could potentially use these findings to develop individual risk profiles and guide decision making.