bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adopting Clean Technologies to Climate Change Adaptation Strategies in Africa: a Systematic Literature Review
Authors: Daka Ephraim 
Published: August 2022

AbstractThe phenomenon of deforestation is occurring globally, in different types of forests, and for various reasons. In Africa, an estimated 90 per cent of the entire continent’s population uses wood as a source energy for heating and cooking. However, the unsustainable harvesting of trees for heating energy not only contribute to forest and environmental degradation, but it is also a significant contributor to ill health, air pollution and climate change. Reducing the resulting adverse of ecological and health consequences will have to involve a mix of adopting renewable fuels and natural resource sustainable strategies. To date, implementing this mix has shown significant challenges, especially in developing countries. We performed this systematic literature review (SLR) to help us better understand how research is approaching this mix in Africa. We screened 792 articles resulting in a final selection of 34 studies concerned with environmental sciences. The review drew on qualitative, quantitative, and regional studies and applying a standardized method for screening, data extraction and synthesis. The findings reveal that current research focuses dominantly in four key areas: (1) renewable technology transfer, (2) climate change-adaptability, (3) climate policy, and (4) technology adoption. However, we identified a literature gap on the thin literature concerned with the impact of clean technologies to improving the environment and people’s wellbeing. We propose planning a tool that would facilitate this process and suggest further research to incorporate monitoring its effectiveness.
Resilience to chronic mild stress-induced anhedonia preserves the ability of the ventral hippocampus to respond to an acute challenge
Authors: Brivio Paola , Gallo Maria Teresa , Gruca Piotr , Lason Magdalena , Litwa Ewa , Fumagalli Fabio , Papp Mariusz , Calabrese Francesca 
Published: August 2022

AbstractStress is a major precipitating factor for psychiatric disorders and its effects may depend on its duration and intensity. Of note, there are differences in individual susceptibility to stress, with some subjects displaying vulnerability and others showing resistance. Furthermore, the ability to react to stressful-life events can alter the response to a subsequent new stressor. Hence, we investigated whether the vulnerability and resilience to the chronic mild stress (CMS) paradigm, in terms of the hedonic phenotype, are paralleled by a different response when facing a novel acute challenge. Specifically, rats submitted to CMS were stratified based on their sucrose intake into vulnerable (anhedonic rats showing reduce intake of sucrose) and resilient (rats not showing the anhedonic-like behavior) subgroups and then further exposed to an acute restraint stress (ARS). Then, neuronal activation was investigated by measuring the gene expression of early immediate (IEG) genes such as Arc and Cfos and early response (ERG) genes, such as Gadd45β, Sgk1, Dusp1, and Nr4a1, in brain regions that play a crucial role in the stress response. We found that resilient rats preserve the ability to increase ERG expression following the ARS selectively in the ventral hippocampus. Conversely, such ability is lost in vulnerable rats. Interestingly, the recovery from the anhedonic phenotype observed in vulnerable rats after 3 weeks of rest from the CMS procedure also parallels the restoration of the ability to adequately respond to the challenge. In conclusion, these findings support the role of the ventral subregion of the hippocampus in the management of both chronic and acute stress response and point to this brain subregion as a critical target for a potential therapeutic strategy aimed at promoting stress resilience.
Neurogranin-like immunoreactivity in the zebrafish brain during development
Authors: Alba-González Anabel , Yáñez Julián , Anadón Ramón , Folgueira Mónica 
Published: August 2022

AbstractNeurogranin (Nrgn) is a neural protein that is enriched in the cerebral cortex and is involved in synaptic plasticity via its interaction with calmodulin. Recently we reported its expression in the brain of the adult zebrafish (Alba-González et al. J Comp Neurol 530:1569–1587, 2022). In this study we analyze the development of Nrgn-like immunoreactivity (Nrgn-like-ir) in the brain and sensory structures of zebrafish embryos and larvae, using whole mounts and sections. First Nrgn-like positive neurons appeared by 2 day post-fertilization (dpf) in restricted areas of the brain, mostly in the pallium, epiphysis and hindbrain. Nrgn-like populations increased noticeably by 3 dpf, reaching an adult-like pattern in 6 dpf. Most Nrgn-like positive neurons were observed in the olfactory organ, retina (most ganglion cells, some amacrine and bipolar cells), pallium, lateral hypothalamus, thalamus, optic tectum, torus semicircularis, octavolateralis area, and viscerosensory column. Immunoreactivity was also observed in axonal tracts originating in Nrgn-like neuronal populations, namely, the projection of Nrgn-like immunopositive primary olfactory fibers to olfactory glomeruli, that of Nrgn-like positive pallial cells to the hypothalamus, the Nrgn-like-ir optic nerve to the pretectum and optic tectum, the Nrgn-like immunolabeled lateral hypothalamus to the contralateral region via the horizontal commissure, the octavolateralis area to the midbrain via the lateral lemniscus, and the viscerosensory column to the dorsal isthmus via the secondary gustatory tract. The late expression of Nrgn in zebrafish neurons is probably related to functional maturation of higher brain centers, as reported in the mammalian telencephalon. The analysis of Nrgn expression in the zebrafish brain suggests that it may be a useful marker for specific neuronal circuitries.
Efficacy and safety of EGFR‑TKIs plus Shenqi Fuzheng injection for non-small cell lung cancer patients with EGFR-sensitive mutations
Authors: Wang Jia-li , Chen Chuan-sheng , Jia Zhi-rong , Miao Li-yun , Xie Jun , Pan Zhen-zhen , Duan Ya-lei , Liu Shuo , Hou Meng-jun , Ding Xuan-sheng 
Published: August 2022

Abstract
Purpose
The aim of this retrospective study is to evaluate the impact on efficacy and safety between epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) alone and in combination with Shenqi Fuzheng injection (SFI) in patients with advanced NSCLC harboring epidermal growth factor receptor (EGFR) activating mutations.

Methods
Retrospectively, information of 88 patients receiving EGFR-TKIs as first-line targeted treatment or in combination with SFI in the Affiliated Drum Tower Hospital of Nanjing University Medical College and the Affiliated Cancer Hospital of Anhui University of Science and Technology was collected. The primary endpoint was to assess progression-free survival (PFS) and safety of EGFR-TKIs alone or in combination with SFI.

Results
Between January 2016 and December 2019, a total of 88 patients were enrolled in this research, including 50 cases in the EGFR-TKIs single agent therapy group and 38 cases in the SFI combined with EGFR-TKIs targeted-therapy group. The median PFS (mPFS) of monotherapy group was 10.50 months (95%CI 9.81–11.19), and 14.30 months (95%CI 10.22–18.38) in the combination therapy group. Compared to the single EGFR-TKIs administration, combinational regimen with SFI exhibited a lower incidence of rash and diarrhea in patients and was even better tolerated.

Conclusions
SFI combined with the first-generation EGFR-TKIs are more efficient, can prominently prolong the PFS and attenuate the adverse reactions in patients with advanced NSCLC with EGFR-sensitive mutations.
Cryptosporidium infection in young dogs from Germany
Authors: Murnik Lea-Christina , Daugschies Arwid , Delling Cora 
Published: August 2022

AbstractCryptosporidium is an enteric protozoan parasite which is able to cause severe gastrointestinal disease and is distributed all over the world. Since information about the prevalence of cryptosporidiosis in German dogs is rare, the aim of this study was to examine the occurrence of Cryptosporidium spp. in dogs and the potential zoonotic risk emanating from these infected animals. In total, 349 fecal samples of 171 dogs were collected during the dogs’ first year of life. The samples were examined for Cryptosporidium spp. using PCR, targeting the small subunit ribosomal RNA gene (SSU rRNA). Further analysis of Cryptosporidium parvum and Cryptosporidium canis positive samples was accomplished using the 60 kDa glycoproteine gene (GP60). Overall, 10.0% (35/349) of the specimens were tested positive for Cryptosporidium. Cryptosporidium canis was found in 94.3% (33/35) of these samples and the zoonotic type C. pavum in 5.7% (2/35). Both C. parvum infections were subtyped as IIaA15G2R1. Sixteen of the C. canis positive samples were successfully amplified at the GP60 gene locus. These isolates were identified to belong to the subtype families XXd, XXe, or XXb; however, 2 samples could not be assigned to any of the described subtype families. Considering the close contact between pets and their owners, dogs may act as a potential source of infection for human cryptosporidiosis. The results of this study, in context with other studies from different countries, provide important further insights into the distribution of Cryptosporidium species in dogs and their zoonotic potential.
Psycholinguistic changes in the communication of adolescent users in a suicidal ideation online community during the COVID-19 pandemic
Authors: Feldhege Johannes , Wolf Markus , Moessner Markus , Bauer Stephanie 
Published: August 2022

AbstractSince the outbreak of the COVID-19 pandemic, increases in suicidal ideation and suicide attempts in adolescents have been registered. Many adolescents experiencing suicidal ideation turn to online communities for social support. In this retrospective observational study, we investigated the communication—language style, contents and user activity—in 7975 unique posts and 51,119 comments by N = 2862 active adolescent users in a large suicidal ideation support community (SISC) on the social media website reddit.com in the onset period of the COVID-19 pandemic. We found significant relative changes in language style markers for hopelessness such as negative emotion words (+ 10.00%) and positive emotion words (− 3.45%) as well as for social disengagement such as social references (− 8.63%) and 2nd person pronouns (− 33.97%) since the outbreak of the pandemic. Using topic modeling with Latent Dirichlet Allocation (LDA), we identified significant changes in content for the topics Hopelessness (+ 23.98%), Suicide Methods (+ 17.11%), Social Support (− 14.91%), and Reaching Out to users (− 28.97%). Changes in user activity point to an increased expression of mental health issues and decreased engagement with other users. The results indicate a potential shift in communication patterns with more adolescent users expressing their suicidal ideation rather than relating with or supporting other users during the COVID-19 pandemic.
Mechanisms of auditory masking in marine mammals
Authors: Branstetter Brian K. , Sills Jillian M. 
Published: August 2022

AbstractAnthropogenic noise is an increasing threat to marine mammals that rely on sound for communication, navigation, detecting prey and predators, and finding mates. Auditory masking is one consequence of anthropogenic noise, the study of which is approached from multiple disciplines including field investigations of animal behavior, noise characterization from in-situ recordings, computational modeling of communication space, and hearing experiments conducted in the laboratory. This paper focuses on laboratory hearing experiments applying psychophysical methods, with an emphasis on the mechanisms that govern auditory masking. Topics include tone detection in simple, complex, and natural noise; mechanisms for comodulation masking release and other forms of release from masking; the role of temporal resolution in auditory masking; and energetic vs informational masking.
Automated privacy negotiations with preference uncertainty
Authors: Filipczuk Dorota , Baarslag Tim , Gerding Enrico H. , schraefel m. c. 
Published: August 2022

AbstractMany service providers require permissions to access privacy-sensitive data that are not necessary for their core functionality. To support users’ privacy management, we propose a novel agent-based negotiation framework to negotiate privacy permissions between users and service providers using a new multi-issue alternating-offer protocol based on exchanges of partial and complete offers. Additionally, we introduce a novel approach to learning users’ preferences in negotiation and present two variants of this approach: one variant personalised to each individual user, and one personalised depending on the user’s privacy type. To evaluate them, we perform a user study with participants, using an experimental tool installed on the participants’ mobile devices. We compare the take-it-or-leave-it approach, in which users are required to accept all permissions requested by a service, to negotiation, which respects their preferences. Our results show that users share personal data 2.5 times more often when they are able to negotiate while maintaining the same level of decision regret. Moreover, negotiation can be less mentally demanding than the take-it-or-leave-it approach and it allows users to align their privacy choices with their preferences. Finally, our findings provide insight into users’ data sharing strategies to guide the future of automated and negotiable privacy management mechanisms.
Racial inequities in second-line treatment and overall survival among patients with metastatic breast cancer
Authors: Whitaker Kristen D. , Wang Xiaoliang , Ascha Mustafa , Showalter Timothy N. , Lewin Heather G. , Calip Gregory S. , Goldstein Lori J. 
Published: August 2022

Abstract
Background
Black women in the USA have a higher incidence and mortality of metastatic breast cancer (mBC) than White women, while Hispanic women have lower rates. Previous studies have focused on first-line (1L) treatment, but little is known about racial differences in treatment beyond 1L and their impact on outcomes.

Methods
This analysis utilized data from an electronic health record derived de-identified database and included patients with HR+HER2- mBC initiating 2L treatment (including CDK4/6-inhibitor [CDKi]-based, endocrine monotherapy, everolimus combination therapy, and chemotherapy and other systemic therapies) between 2/3/2015 and 7/31/2021. Real-world overall survival (rwOS) was defined as time from 2L initiation to death. Multinomial logistic regression assessed the likelihood of 2L treatment between race/ethnicity groups. Median rwOS was estimated using the Kaplan–Meier method and adjusted hazard ratios were estimated using multivariable Cox proportional hazards models.

Results
Among all patients who received 2L, non-Hispanic Black (NHB) and Hispanic/Latino patients were less likely to receive 2L CDKi compared to non-Hispanic White (NHW) patients (36%, 39% vs 42%, respectively). Median rwOS was 20.4, 37.6, and 25.3 months, in NHB, Hispanic/Latino and NHW patients, respectively. The rwOS remained poorer among NHB patients after adjustment (HR = 1.16; p = 0.009). In stratified analysis, adjusted rwOS was similar between NHB and NHW patients among those who received 1L CDKi.

Conclusions
These findings suggest that among patients with HR+HER2- mBC, NHB patients had worse survival beyond front-line setting, mainly among the subset of women who did not receive CDKi at 1L. This inequities in rwOS between race/ethnicity groups was not observed among patients who received 1L CDKi.
Putative anoikis resistant subpopulations are enriched in lymph node metastases and indicate adverse prognosis in colorectal carcinoma
Authors: Mattila Taneli T. , Patankar Madhura , Väyrynen Juha P. , Klintrup Kai , Mäkelä Jyrki , Tuomisto Anne , Nieminen Pentti , Mäkinen Markus J. , Karttunen Tuomo J. 
Published: August 2022

AbstractAnoikis refers to apoptosis induced by the loss of contact with the extracellular matrix. Anoikis resistance is essential for metastasis. We have recently shown that it is possible to quantitatively evaluate putative anoikis resistant (AR) subpopulations in colorectal carcinoma (CRC). Abundance of these multi-cell structures is an independent marker of adverse prognosis. Here, we have quantified putative AR subpopulations in lymph node (LN) metastases of CRC and evaluated their prognostic value and relationship with the characteristics of primary tumors. A case series included 137 unselected CRC patients, 54 with LN metastases. Areal densities (structures/mm2) of putative AR structures in primary tumors had been analyzed previously and now were determined from all nodal metastases (n = 183). Areal density of putative AR structures was higher in LN metastases than in primary tumors. Variation of the areal density within different LN metastases of a single patient was lower than between metastases of different patients. Abundance of putative AR structures in LN metastases was associated with shorter cancer specific survival (p = 0.013), and this association was independent of T and N stages. Abundance of putative AR structures in primary tumors and LN metastases had a cumulative adverse effect on prognosis. Enrichment of putative AR subpopulations in LN metastases suggest that in metastasis formation, there is a selection favoring cells capable of forming these structures. Higher intra-case constancy relative to inter-case variation suggests that such selection is stable in metastasis development. Our findings indirectly support the biological validity of our concept of putative AR structures.
Prot2Prot: a deep learning model for rapid, photorealistic macromolecular visualization
Authors: Durrant Jacob D. 
Published: August 2022

AbstractMolecular visualization is a cornerstone of structural biology, providing insights into the form and function of biomolecules that are difficult to achieve any other way. Scientific analysis, publication, education, and outreach often benefit from photorealistic molecular depictions rendered using advanced computer-graphics programs such as Maya, 3ds Max, and Blender. However, setting up molecular scenes in these programs is laborious even for expert users, and rendering often requires substantial time and computer resources. We have created a deep-learning model called Prot2Prot that quickly imitates photorealistic visualization styles, given a much simpler, easy-to-generate molecular representation. The resulting images are often indistinguishable from images rendered using industry-standard 3D graphics programs, but they can be created in a fraction of the time, even when running in a web browser. To the best of our knowledge, Prot2Prot is the first example of image-to-image translation applied to macromolecular visualization. Prot2Prot is available free of charge, released under the terms of the Apache License, Version 2.0. Users can access a Prot2Prot-powered web app without registration at http://durrantlab.com/prot2prot.
Drones, Real Estate Video Surveillance, and Neighbourhood Right to Privacy – The Potential Area of Normative Impact from the Perspective of the Polish Law
Authors: Stępień-Załucka Beata 
Published: August 2022

Abstract
The use of new technologies covers more and more areas of social life, including securing and protecting property, especially real estate. For these purposes cameras mounted on drones may be used, allowing the possibility to record vidoes containing an overview of the monitored property (real estate). However, this type of property protection may also be connected with the violation of rights of neighboring property owners which are monitored indirectly. These issues are presented in this paper, where the author discusses, inter alia, what risks are associated with the implementation of neighborhood video surveillance done with drones and its consequences. Based on the indicated research area, the author wonders in particular on the provisions of the constitutional right to privacy and personal rights defined in the private law legislation, including its international dimension connected with ECHR and GDPR. The presentation containes observations made from the point of view of the Polish law, where—as in many other legal jurisdictions—these issues have not yet been resolved legislatively, and where the search for an optimal model for resolving similar problems is still underway. For this reason, the author tries to outline the potential area of normative impact of the phenomenon of real estate monitoring by drones, which may become helpful in the forthcoming legislative projects concerning the normalization of this phenomenon.
Aliasing and adversarial robust generalization of CNNs
Authors: Grabinski Julia , Keuper Janis , Keuper Margret 
Published: August 2022

AbstractMany commonly well-performing convolutional neural network models have shown to be susceptible to input data perturbations, indicating a low model robustness. To reveal model weaknesses, adversarial attacks are specifically optimized to generate small, barely perceivable image perturbations that flip the model prediction. Robustness against attacks can be gained by using adversarial examples during training, which in most cases reduces the measurable model attackability. Unfortunately, this technique can lead to robust overfitting, which results in non-robust models. In this paper, we analyze adversarially trained, robust models in the context of a specific network operation, the downsampling layer, and provide evidence that robust models have learned to downsample more accurately and suffer significantly less from downsampling artifacts, aka. aliasing, than baseline models. In the case of robust overfitting, we observe a strong increase in aliasing and propose a novel early stopping approach based on the measurement of aliasing.
The whole picture: Disentangling locality, logophoricity and subjecthood in English picture noun anaphora
Authors: Charnavel Isabelle , Bryant Shannon 
Published: August 2022

AbstractThis article provides a solution to the long-standing puzzle of English anaphors within so-called picture noun phrases, which superficially exhibit an exceptional binding behavior. In particular, picture noun anaphors seem, under certain conditions, to escape the locality conditions imposed by Condition A of Binding Theory. Previous proposals attribute such apparently exceptional behavior to various sources: the classical Binding Theory appeals to the possible presence of covert agents within NPs; predicate-based theories introduce the possibility of exemption from Condition A; others capitalize on possible homophony with (logophoric) pronouns. While all of these proposals provide valuable insight into some aspect of the puzzle, we show that they all fail to capture the full empirical picture. Based on a detailed examination of their behavior in various syntactic and interpretive conditions, we instead propose that English picture noun anaphors, like any other anaphor, systematically obey Condition A. Their apparent exemption from it in some cases derives from the possible implicitness of some binders, in particular, logophoric pronouns or nominal subjects. Furthermore, the availability of such covert binders is crucially affected by a binding-independent competition principle between weaker and stronger forms. Thus, the apparently irregular behavior of English picture noun anaphors results from the interaction between several factors (syntactic representation of logophoricity, syntactic projection of subjects in nouns, pronominal competition), which is responsible for the illusion that Condition A does not apply systematically. By disentangling these factors, we propose a solution that integrates previous insights without compromising on empirical adequacy or analytical parsimony.