bluuebunny/crossref_metadata_2025_split huggingface dataset:
Обґрунтування підходу до вдосконалення стратегічного планування в силах оборони
Authors: Коваль М. , Наливайко А. 
Published: November 2022

Однією з важливих складових формування, розвитку й функціонування сил оборони України є стратегічне планування, яке в умовах збройної агресії проти України з боку Російської Федерації потребує термінового вдосконаленням, оскільки існуюче планування на даний час не в змозі охопити весь спектр завдань, які визначені національним законодавством у сфері оборони.Однією з причин такого стану на сьогодні є відсутність цілісної системи державного стратегічного планування, складовою частиною якого є стратегічного планування в силах оборони.
Метою статті є дослідження та обґрунтування ефективніших підходів до вдосконалення стратегічного планування у силах оборони для сучасних безпекових умов.
Визначені основні кроки розроблення стратегічного плану:
- підготовка до процесу стратегічного планування;
- аналіз майбутнього безпекового середовища;
- визначення візії та місії органу управління складових сил оборони;
- визначення стратегічної мети та цілей розвитку спроможностей сил оборони;
- визначення завдань та показників для досягнення визначених стратегічних цілей;
- розроблення стратегічного плану складових сил оборони, який містить певні етапи його формування;
- реалізація стратегічного плану та моніторинг його виконання.
Розроблення стратегічного плану розвитку сил оборони, як специфічний вид діяльності, ‑ це послідовний ітераційний процес, що складається з сукупності взаємопов’язаних етапів. Запропоновано порядок розроблення і контролю виконання стратегічного плану розвитку складових сил оборони
В рамках практичної реалізації наданих пропозицій уточнені відомі визначення і терміни теорії стратегічного планування та запропонованопорядок розробки документу оборонного планування.
Chemical elicitation as an avenue for discovery of bioactive compounds from fungal endophytes
Authors: Munusamy Madhaiyan , Ching Kuan Chieh , Yang Lay Kien , Crasta Sharon , Gakuubi Martin Muthee , Chee Zhao Yan , Wibowo Mario , Leong Chung Yan , Kanagasundaram Yoganathan , Ng Siew Bee 
Published: November 2022

The present study investigated the molecular phylogeny, antimicrobial and cytotoxic activities of fungal endophytes obtained from the A*STAR Natural Organism Library (NOL) and previously isolated from Sungei Buloh Wetland Reserve, Singapore. Phylogenetic analysis based on ITS2 gene suggests that these isolates belong to 46 morphotypes and are affiliated to 23 different taxa in 17 genera of the Ascomycota phylum. Colletotrichum was the most dominant fungal genus accounting for 37% of all the isolates, followed by Diaporthe (13%), Phyllosticta (10.9%) and Diplodia (8.7%). Chemical elicitation using 5-azacytidine, a DNA methyltransferase inhibitor and suberoylanilide hydroxamic acid, a histone deacetylase inhibitor resulted in an increase in the number of active strains. Bioassay-guided isolation and structural elucidation yielded pestahivin and two new analogues from Bartalinia sp. F9447. Pestahivin and its related analogues did not exhibit antibacterial activity against Staphylococcus aureus but displayed strong antifungal activities against Candida albicans and Aspergillus brasiliensis, with IC50 values ranging from 0.46 ± 0.06 to 144 ± 18 µM. Pestahivin and its two analogues furthermore exhibited cytotoxic activity against A549 and MIA PACA-2 cancer cell lines with IC50 values in the range of 0.65 ± 0.12 to 42 ± 5.2 µM. The finding from this study reinforces that chemical epigenetic induction is a promising approach for the discovery of bioactive fungal secondary metabolites encoded by cryptic gene clusters.
Biological synthesis of hybrid silver nanoparticles by Periploca aphylla Dcne. From nanotechnology to biotechnology applications
Authors: Arshad Saba , Anwar Natasha , Rauf Mamoona , Anwar Zeeshan , Shah Mohib , Hamayun Muhammad , Ud-Din Jalal , Gul Humaira , Nasim Sahar , Lee In-Jung , Arif Muhammad 
Published: November 2022

Nanotechnology is one of the advanced technologies that have almost universal implications in every field of science. The importance is due to the unique properties of nanoparticles; however, green synthesized nanoparticles are considered eco-friendly. The current project was rationalized to prepare green-synthesized biogenic Periploca aphylla Dcne. silver nanoparticles (Pe-AgNPs) and poly (ethylene glycol) methacrylate coated AgNPs nanocomposites (PEGMA-AgNPs) with higher potential for their application in plant tissue culture for enhancing the biomass of Stevia rebaudiana calli. The increased biomass accumulation (17.61 g/3 plates) was observed on a medium containing virgin Pe-AgNPs 40th days after incubation, while the maximum increase was found by supplementing virgin Pe-AgNPs and PEGMA capped AgNPs (19.56 g/3 plates), compared with control (12.01 g/3 plates). In this study, PEGMA capped AgNPs supplementation also induced the maximum increase in total phenolics content (2.46 mg GAE/g-FW), total flavonoids content (3.68 mg QE/g-FW), SOD activity (53.78 U/ml protein), GSH content (139.75 μg/g FW), antioxidant activity (54.3 mg AAE/g FW), FRAP (54 mg AAE/g FW), and DPPH (76.3%) in S. rebaudiana calli compared with the control. It was concluded that virgin Pe-AgNPs and PEGMA capped AgNPs (hybrid polymer) are potent growth regulator agents and elicitors that can be exploited in the biotechnology field for growth promotion and induction of essential bioactive compounds and secondary metabolites from various commercially important and medicinally valuable plants such as S. rebaudiana without laborious field cultivation.
A retrospective study of thoracic endovascular aortic repair timing in patients with uncomplicated type B dissection who have a smoking history
Authors: Gao Hui-Qiang , Li Guoqi , Zhang Hong-Kai , Zhang Lan-Lin , Xu Shang-Dong 
Published: November 2022

ObjectiveTo determine the optimal timing of thoracic endovascular aortic repair (TEVAR) for patients with uncomplicated type B dissections who have a smoking history.MethodsData from 308 consecutive patients with uncomplicated type B dissections, who have a smoking history and onset-to-TEVAR time within 90 days, were analyzed. The patients were divided into two groups: Acute and subacute phases. Univariate and multivariate regression analyses were performed. Smooth curve fitting and threshold analysis were performed to characterize the relationship between the onset-to-TEVAR time and follow-up deaths.ResultsThere were no significant differences between the two groups. Smooth curve fitting and threshold effect analysis showed that if early TEVAR was performed within 9.4 days from onset, there was better long-term survival and there was no significant difference after 9.4 days.ConclusionBy studying the relationship between onset-to-TEVAR time and all-cause mortality, we found that early TEVAR may have a lower all-cause mortality rate during follow-up in uncomplicated type B dissection patients who have a smoking history and within 90 days from onset.
Myocardial injury and its correlation to mortality in hospitalized COVID-19 patients: A retrospective cohort study
Authors: Ababneh Muhannad J. , Al-Kasasbeh Abdullah , Jarrah Mohamad , Malkawi Lujain , Sanduka Omar , Smadi Areje M. , Smadi Mahmoud M. 
Published: November 2022

PurposeThis retrospective observational study was conducted to assess the clinical characteristics and outcomes of hospitalized COVID-19 patients with positive cardiac enzymes in the King Abdullah University Hospital (KAUH) in Irbid, Jordan.Patients and methodsA total of 676 patients admitted to KAUH for moderate-to-severe COVID-19 were included in the study. Clinical and mortality data were collected from patients’ electronic medical records.ResultsA significant association was found between myocardial injury and In-hospital mortality. Seven comorbidities were identified as risk factors for myocardial injury: Hypertension, diabetes mellitus (DM), previous cerebrovascular accident (CVA), ischemic heart disease (IHD), heart failure, chronic kidney disease (CKD), and cardiac arrhythmias. The need for intensive care unit (ICU) for invasive ventilation was also associated with myocardial injury. Acute kidney injury (AKI) during hospitalization had a significantly higher incidence of myocardial injury and mortality. Acute myocardial infarction (MI) and acute peripheral vascular disease (PVD) were also associated with higher mortality.ConclusionMyocardial injury is an important predictor of mortality in patients with moderate-to-severe COVID-19 disease. Patients with a history of hypertension, diabetes mellitus, any vascular diseases, cardiac arrhythmias or heart failure are considered high-risk for adverse outcome. Additionally, COVID-19 patients with myocardial injury and acute kidney injury were recognized with the highest mortality rate.
Association between psoriasis and coronary artery calcification: A systematic review and meta-analysis
Authors: Wu Huihui , Luo Zeyu , Liu Juanhua , Luo Diqing , Song Luli , Zhao Yukun 
Published: November 2022

BackgroundPsoriasis and atherosclerosis have overlapping pathophysiological mechanisms. However, the association between psoriasis and coronary artery calcification (CAC), a hallmark of atherosclerosis and a predictor of poor cardiovascular prognosis, remains to be determined. We performed a systematic review and meta-analysis to comprehensively evaluate the association between these related inflammatory conditions.MethodsObservational studies evaluating the relationship between psoriasis and CAC were retrieved by searching PubMed, Cochrane’s Library, and Embase databases. Presence of CAC was confirmed according to an Agatston’s Score &gt;0 upon computed tomography examination. A random-effect model incorporating between-study heterogeneity was used to pool the results.ResultsSixteen studies involving 3,039 patients with psoriasis and 46,191 controls without psoriasis were included in the meta-analysis. All participants were without previously known cardiovascular diseases. Pooled results showed that psoriasis was associated with overall CAC [odds ratio (OR): 1.54, 95% confidence interval: 1.23–1.91, p &lt; 0.001; I2 = 57%], after matching or adjusting the conventional cardiovascular risk factors. Subgroup analyses showed that study country, comorbidity of psoriatic arthritis, baseline Psoriasis Area and Severity Index, and duration of psoriasis (p for subgroup difference all &gt;0.05) did not significantly affect the association of psoriasis and CAC. However, a stronger association was observed in younger patients (mean age &lt;50 years, OR: 2.63, p &lt; 0.001) compared to older patients (≥50 years, OR: 1.24, p = 0.02; p for subgroup difference &lt;0.001).ConclusionPsoriasis is associated with CAC, and the association may be stronger in younger patients.
Simulating computerized adaptive testing in special education based on inclusive progress monitoring data
Authors: Ebenbeck Nikola , Gebhardt Markus 
Published: November 2022

IntroductionAdaptive tests have advantages especially for children with special needs but are rarely used in practice. Therefore, we have investigated for our web-based progress-monitoring platform www.levumi.de of how to build adaptive tests based on existing item pools by computerized adaptive testing (CAT). In this study, we explore the requirements of item pools and necessary settings of computerized adaptive testing in special education and inclusion in order to achieve both short test length and good test accuracy.MethodsWe used existing items fitted to the Rasch model and data samples of progress monitoring tests (N = 681) for mathematics and reading to create two item pools for adaptive testing. In a simulation study (N = 4,000), we compared different test lengths and test accuracies as stopping rules with regard to an inclusive use of adaptive testing.ResultsThe results show an optimal maximum test length of 37 and 24 items, with a target standard error for accuracy of 0.5. These results correspond to an average execution time of about 3 min per test.DiscussionThe results are discussed in terms of the use of adaptive testing in inclusive settings and the applicability of such adaptive tests as screenings, focusing mainly on students with special needs in learning, language, or behavior.
Pretreatment of NaCl enhances the drought resistance of cotton by regulating the biosynthesis of carotenoids and abscisic acid
Authors: Ni Kesong , Dai Maohua , Lu Xuke , Zhang Yuexin , Fan Yapeng , Xu Nan , Feng Xixian , Huang Hui , Wang Jing , Rui Cun , Zhang Hong , Lei Yuqian , Liu Xiaoyu , Jiang Tiantian , Han Mingge , Sun Liangqing , Chen Xiugui , Wang Delong , Wang Junjuan , Wang Shuai , Chen Chao , Guo Lixue , Zhao Lanjie , Ye Wuwei 
Published: November 2022

Drought stress is one of the abiotic stresses that limits crop production and greatly affects crop yield. Enhancement of plant stress resistance by NaCl pretreatment has been reported, but the mechanism by which NaCl pretreatment activates cotton stress resistance remains unclear. In this study, upland cotton (Gossypium hirsutum cv H177) was used as the material to conducted the treatments with three replications: 0 Mm NaCl + 0% PEG6000 (Polyethylene glycol), 0 mM NaCl + 15% PEG6000, 50 mM NaCl + 15% PEG6000 to explore the molecular mechanism by which NaCl improves the drought tolerance of cotton. The results showed that pretreatment with 50 mM NaCl could alleviate the adverse effects of PEG on cotton seeds while promoting the elongation of root length. RNA-seq showed that NaCl specifically induced the expression of carotenoid-related genes. By silencing the upstream gene GHLUT2 of lutein synthesis, it was found that the chlorophyll of silenced plants decreased, and leaf wilting was more sensitive to drought. We found that NaCl enhanced the drought resistance of cotton by regulating genes related to the carotenoid and abscisic acid downstream synthesis pathways. This study provides a new reference for the study of drought resistance in cotton and a theoretical basis for the molecular breeding of cotton.
Testing the validity of the core-shell-surface layer model on the size dependence of effective magnetic anisotropy in magnetic nanoparticles
Authors: Singh Sobhit , Seehra Mohindar S. 
Published: November 2022

The stability of the stored information in magnetic recording media depends on the anisotropy energy Ea (=KeffV) of nanoparticles (NPs) of volume V or diameter D. Therefore, it is important to know how the effective anisotropy constant Keff varies with size D of the NPs. In a recent paper [Appl. Phys. Lett. 110, 222409 (2017)], the observed Keff versus D variation in NPs of maghemite (γ-Fe2O3) was explained on the basis of the core-shell-surface layer (CSSL) model given by Eq.: Keff = Kb + (6KS/D) +Ksh{[1-(2d/D)]−3–1}, where Kb,KS, and Ksh are the anisotropy constants of spins in the core, surface layer, and a shell of thickness d, respectively. This CSSL model is an extension of an earlier core-surface layer (CSL) model described by Keff = Kb + (6KS/D) [Phys. Rev. Lett. 72, 282 (1994)] proposed to explain the Keff versus D variation in Fe NPs. For the NPs of γ-Fe2O3, the additional term of the CSSL model involving Ksh was found to be necessary to fit the data for sizes D &lt; 5 nm. In this paper, we report the validity of the CSSL model for NPs of several other systems viz. Co, Ni, NiO, and Fe3O4 using the available data from literature. In selecting the data, care was taken to consider data only for non-interacting NPs since the interparticle interactions generally overshadow the actual value of Keff in NPs. It is shown that the new CSSL model describes very well the Keff vs. D variation for all particle sizes whereas the CSL model fails for smaller particles with the notable exception of Fe NPs. This validation of the CSSL model for the NPs of Co, Ni, NiO, Fe3O4, and γ-Fe2O3 suggests its general validity for magnetic NPs. Discussion is also presented on the comparative magnitudes of the parameters Kb, KS, and Ksh obtained from the fits to the CSSL model.
Interaction between human leukocyte antigen (HLA-C) and killer cell Ig-like receptors (KIR2DL) inhibits the cytotoxicity of natural killer cells in patients with hepatoblastoma
Authors: Guo Jing-Jie , Ye Yong-Qin , Liu Yi-Di , Wu Wei-Fang , Mei Qian-Qian , Zhang Xi-Yun , Lao Jing , Wang Bin , Wang Jian-Yao 
Published: November 2022

BackgroundHepatoblastoma (HB) is the most common liver malignancy in childhood with poor prognosis and lack of effective therapeutic targets. Single-cell transcriptome sequencing technology has been widely used in the study of malignant tumors, which can understand the tumor microenvironment and tumor heterogeneity.Materials and methodsTwo children with HB and a healthy child were selected as the research subjects. Peripheral blood and tumor tissue were collected for single-cell transcriptome sequencing, and the sequencing data were compared and analyzed to describe the differences in the immune microenvironment between children with HB and normal children.ResultsThere were significant differences in the number and gene expression levels of natural killer cells (NK cells) between children with HB and normal children. More natural killer cells were seen in children with HB compared to normal control. KIR2DL were highly expressed in children with HB.ConclusionSingle-cell transcriptome sequencing of peripheral blood mononuclear cells (PBMC) and tumor tissue from children with HB revealed that KIR2DL was significantly up-regulated in NK cells from children with HB. HLA-C molecules on the surface of tumor cells interact with inhibitory receptor KIR2DL on the surface of NK cells, inhibiting the cytotoxicity of NK cells, resulting in immune escape of tumors. Inhibitors of related immune checkpoints to block the interaction between HLA-C and KIR2DL and enhance the cytotoxicity of NK cells, which may be a new strategy for HB treatment.
Janus kinases inhibitors for coronavirus disease-2019: A pairwise and Bayesian network meta-analysis
Authors: Niu Jianyi , Lin Zhiwei , He Zhenfeng , Yang Xiaojing , Qin Lijie , Feng Shengchuan , Guan Lili , Zhou Luqian , Chen Rongchang 
Published: November 2022

BackgroundJAK (Janus kinases) inhibitors have been proposed as a promising treatment option for the coronavirus disease-2019 (COVID-19). However, the benefits of JAK inhibitors and the optimum thereof for COVID-19 have not been adequately defined.MethodsDatabases were searched from their inception dates to 17 June 2022. Eligible studies included randomized controlled trials and observational studies. Extracted data were analyzed by pairwise and network meta-analysis. The primary outcome was the coefficient of mortality.ResultsTwenty-eight studies of 8,206 patients were included and assessed qualitatively (modified Jadad and Newcastle–Ottawa Scale scores). A pairwise meta-analysis revealed that JAK inhibitors effectively reduced the mortality (OR = 0.54; 95% CI: 0.46–0.63; P &lt; 0.00001; I2 = 32%) without increasing the risk of adverse events (OR = 1.02; 95% CI: 0.88–1.18; P = 0.79; I2 = 12%). In a network meta-analysis, clinical efficacy benefits were seen among different types of JAK inhibitors (baricitinib, ruxolitinib, and tofacitinib) without the observation of a declined incidence of adverse events. The assessment of rank probabilities indicated that ruxolitinib presented the greatest likelihood of benefits regarding mortality and adverse events.ConclusionJAK inhibitors appear to be a promising treatment for COVID-19 concerning reducing mortality, and they do not increase the risk of adverse events vs. standard of care. A network meta-analysis suggests that mortality benefits are associated with specific JAK inhibitors, and among these, ruxolitinib presents the greatest likelihood of having benefits for mortality and adverse events.Systematic review registration[www.crd.york.ac.uk/prospero], identifier [CRD42022343338].
Biodegradable manganese-doped hydroxyapatite antitumor adjuvant as a promising photo-therapeutic for cancer treatment
Authors: Park Sumin , Choi Jaeyeop , Doan Vu Hoang Minh , O Se Hwi 
Published: November 2022

The efficiency of a cancer therapy agent depends on its ability to eliminate tumors without endangering neighboring healthy tissues. In this present study, a novel multifunctional property enriched nanostructured system was synthesized on manganese-doped hydroxyapatite (Mn-HAp) conjugated with counter folic acid (FA) IR-783 fluorescence dye. The tailored synthesis of nano rod-shaped Mn-HAp nanoparticles with high surface area allows to conjugate FA/IR-783 dye which enhanced retention time during in vivo circulation. The drug-free Photothermal Photodynamic therapy mediated cancer treatment permits the prevention of collateral damages to non-cancerous cells. The safe HAp biomaterial matrix allows a large number of molecules on its surface due to its active different charge moieties (Ca2+/PO43-) without any recurrence toxicity. The doped Mn allows releasing of Mn2+ ions which triggered the production of toxic hydroxyl radicals (•OH) via Fenton or Fenton-like reactions to decompose H2O2 in the tumor sites. Herein, IR-783 and FA were selected for targeted fluorescence imaging-guided photothermal therapy. 6The PTT performance of synthesized nanostructured system shows enhanced potential with ∼60°C temperature elevation with 0.75 W∙cm−2 power irradiated within 7 min of treatment. PDT activity was also observed initially with Methylene Blue (MB) as a targeted material which shows a drastic degradation of MB and further in vitro studies with MDA-MB-231 breast cancer cell line show cytotoxicity due to the generated reactive oxygen species (ROS) effect. FA/IR-783 conjugated Mn-HAp nanoparticles (2.0 mol% Mn-HAp/FA-IR-783) show significant tumor-specific targeting and treatment efficiency while intravenously injected in (tail vain) BALB/c nude mice model without any recurrence. The synthesized nanostructured system had ample scope to be a promising Photo-Therapeutic agent for cancer treatment.
VEEG monitoring and electrographic seizures in 232 pediatric patients in ICU at a tertiary hospital in China
Authors: Sang Tian , Wang Ying , Wu Ye , Guan Qiao , Yang ZhiXian 
Published: November 2022

ObjectivesTo investigate neonatal electroencephalography (EEG) background activity and electrographic seizures in patients in the pediatric intensive care unit (PICU) who underwent bedside video-electroencephalography (vEEG) monitoring.MethodsA total of 232 pediatric patients admitted or transferred to PICU that underwent vEEG monitoring were retrospectively enrolled in this study, and electrographic status epilepticus was observed after vEEG monitoring.ResultsThe median age was 1.56 years [95% confidence interval (CI) = 1.12–2.44]. Electrographic seizures occurred in 88 patients (37.9%), out of which 36 cases (40.9%) had electrographic status epilepticus. Prior epileptic encephalopathy diagnosis [odds ratio (OR) = 6.57, 95% CI = 1.91–22.59, p = 0.003], interictal epileptiform discharges (OR = 46.82, 95%CI = 5.31–412.86, p = 0.0005), slow disorganized EEG background (OR = 11.92, 95%CI = 1.31–108.71, p = 0.028), and burst-suppression EEG background (OR = 23.64, 95%CI = 1.71–327.57, p = 0.018) were the risk factors for electrographic seizures' occurrence. Of the 232 patients, the condition of 179 (77.2%) patients improved and they were discharged, 34 cases (14.7%) were withdrawn, and 18 cases (7.8%) died. The in-hospital death rate was 47.6% (10 in 21 cases) in patients with attenuated/featureless, compared to 0/23 with normal EEG background.ConclusionsElectrographic status epilepticus occurs in more than one-third of patients with electrographic seizures. vEEG is an efficient method to determine electrographic seizures in children. Abnormal EEG background activity is associated with both electrographic seizures' occurrence and unfavorable in-hospital outcomes.