bluuebunny/crossref_metadata_2025_split huggingface dataset:
INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease
Authors: Lin Peter Bor‐Chian , Tsai Andy Po‐Yi , Soni Disha , Lee‐Gosselin Audrey , Moutinho Miguel , Puntambekar Shweta S. , Landreth Gary E. , Lamb Bruce T. , Oblak Adrian L. 
Published: December 2022

AbstractIntroductionInositol polyphosphate‐5‐phosphatase (INPP5D) is a microglia‐enriched lipid phosphatase in the central nervous system. A non‐coding variant (rs35349669) in INPP5D increases the risk for Alzheimer's disease (AD), and elevated INPP5D expression is associated with increased plaque deposition. INPP5D negatively regulates signaling via several microglial cell surface receptors, including triggering receptor expressed on myeloid cells 2 (TREM2); however, the impact of INPP5D inhibition on AD pathology remains unclear.MethodsWe used the 5xFAD mouse model of amyloidosis to assess how Inpp5d haplodeficiency regulates amyloid pathogenesis.ResultsInpp5d haplodeficiency perturbs the microglial intracellular signaling pathways regulating the immune response, including phagocytosis and clearing of amyloid beta (Aβ). It is important to note that Inpp5d haploinsufficiency leads to the preservation of cognitive function. Spatial transcriptomic analysis revealed that pathways altered by Inpp5d haploinsufficiency are related to synaptic regulation and immune cell activation.ConclusionThese data demonstrate that Inpp5d haplodeficiency enhances microglial functions by increasing plaque clearance and preserves cognitive abilities in 5xFAD mice. Inhibition of INPP5D is a potential therapeutic strategy for AD.
Enabling LiNO3 in carbonate electrolytes by flame‐retardant electrolyte additive as a cosolvent for enhanced performance of lithium metal batteries
Authors: Winter Eric , Briccola Mariano , Schmidt Thomas J. , Trabesinger Sigita 
Published: December 2022

AbstractMost contemporary liquid Li‐ion battery chemistries are based on carbonate electrolytes, however, these typically perform poorly with metallic lithium. Especially, when only a small reservoir of metal is present, cells fail quickly due to the complete consumption of electrochemically active Li. Electrolyte modification is, therefore, a commonly chosen strategy to increase cycling stability and prolong lifetime of the cell. At the same time, complete redevelopment of an electrolyte usually creates a new set of problems, as conductivity, suitable electrochemical stability window and compatibility to all components of the cell needs to be ensured. It is, therefore, a reasonable strategy to alter existing electrolytes slightly, as has been done for the aforementioned carbonate electrolytes by incorporating lithium nitrate salt with triethyl phosphate as cosolvent into the mixture. As the role of the organophosphate is not fully clarified, our study aims to investigate its effect onto cycling stability, morphology, and reversibility of Li metal cycling both with and without LiNO3 salt. Using close‐to‐industrial conditions with limited excess of metallic Li at high current density, we are comparing cycling performance of the different electrolyte combinations. Contribution of the additive components to irreversible thickness growth due to the formation of inactive (“dead”) lithium and deposited lithium morphology is investigated by operando dilatometry and postmortem scanning electron microscopy. Finally, we are looking at modified solvent‐salt ratios to see whether further improvements of cell lifetime and morphology can be achieved.
A Highly Reversible Aqueous Ammonium‐Ion Battery based on α‐MoO3/Ti3C2Tz Anodes and (NH4)xMnO2/CNTs Cathodes
Authors: Yang Li , Zheng Wei , Halim Joseph , Rosen Johanna , Sun ZhengMing , Barsoum Michel W. 
Published: December 2022

AbstractAqueous ammonium‐ion batteries (AAIBs) are appealing due to their relatively low cost and good rate performance. In general, AAIBs are environmentally friendlier than their non‐aqueous counterparts. However, it is still a challenge to achieve highly reversible AAIBs with decent voltages and energy/power densities. Herein, we report on a full‐cell configuration using α‐MoO3/Ti3C2Tz films as anodes, and (NH4)xMnO2/CNTs films as cathodes in a 1 M ammonium acetate (NH4Ac) electrolyte. At 2 V, the operating cell voltage, OCV, is one of the highest reported for AAIBs. A maximum energy density of ∼32 Wh kg−1 (∼54 Wh L−1) at 0.2 A g−1 and a maximum power density of ∼10 kW kg−1 (∼17 kW L−1) at 10 A g−1 are attained. When the full cells are cycled 2,000 times at 1 A g−1 they retain ∼73 % of their initial capacity. When cycling at 10 A g−1, ∼96 % of capacity is retained after 43,500 cycles. After 10 h, self‐discharge reduces the OCV to ∼72 % of its original value. This work provides a roadmap for developing high performance AAIBs with high voltages and high energy/power densities. Before this is possible it is imperative that the self‐discharge rate be substantially reduced.
The intersection of environmental and sustainability education, and character education: An instrumental case study
Authors: Jordan Karen E. 
Published: December 2022

AbstractAlthough fostering values is promoted within environmental and sustainability education (ESE) and a shift in values is seen as essential for a sustainable future, recent international findings indicate that this aspect of ESE is being neglected. Previous research has shown there to be common ground between ESE and the field of character education (CE), a form of values education. Bringing together these two strands of theory and practice has the potential to be fruitful in terms of strengthening current, and introducing new, practices in both fields, particularly through drawing on existing evidence‐based strategies within CE to inform ESE. While there has been some work in this regard, this has been almost exclusively theoretical and there has been little research regarding thepracticeof such integration. This paper details an instrumental case study exploring an existing case of where ESE and CE come together in practice. A study was conducted at a Scottish, independent, all‐ages, holistic education‐oriented school, exploring how ESE is carried out. Data were gathered via teacher interviews, school observations, field notes and document analysis. Thematic analysis revealed four themes: the school as a sustainable organism; holistic learning; fostering a connectedness with nature; and nurturing the whole person. The data were then analysed from a CE perspective revealing multiple points of ESE–CE intersection, e.g. school climate/ethos, role‐modelling and service‐learning. The findings reveal commonalities between ESE and CE and provide examples of integrated ESE–CE practice, demonstrating potential for collaboration or shared ESE–CE practice. Avenues for further research are suggested.
Dentin regeneration based on tooth tissue engineering: A review
Authors: Azaryan Ehsaneh , Emadian Razavi Fariba , Hanafi‐Bojd Mohammad Yahya , Alemzadeh Esmat , Naseri Mohsen 
Published: December 2022

AbstractMissing or damaged teeth due to caries, genetic disorders, oral cancer, or infection may contribute to physical and mental impairment that reduces the quality of life. Despite major progress in dental tissue repair and those replacing missing teeth with prostheses, clinical treatments are not yet entirely satisfactory, as they do not regenerate tissues with natural teeth features. Therefore, much of the focus has centered on tissue engineering (TE) based on dental stem/progenitor cells to create bioengineered dental tissues. Many in vitro and in vivo studies have shown the use of cells in regenerating sections of a tooth or a whole tooth. Tooth tissue engineering (TTE), as a promising method for dental tissue regeneration, can form durable biological substitutes for soft and mineralized dental tissues. The cell‐based TE approach, which directly seeds cells and bioactive components onto the biodegradable scaffolds, is currently the most potential method. Three essential components of this strategy are cells, scaffolds, and growth factors (GFs). This study investigates dentin regeneration after an injury such as caries using TE and stem/progenitor cell‐based strategies. We begin by discussing about the biological structure of a dentin and dentinogenesis. The engineering of teeth requires knowledge of the processes that underlie the growth of an organ or tissue. Then, the three fundamental requirements for dentin regeneration, namely cell sources, GFs, and scaffolds are covered in the current study, which may ultimately lead to new insights in this field.
A novel nomogram for the preoperative prediction of sentinel lymph node metastasis in breast cancer
Authors: Wang Xue‐fei , Zhang Guo‐chao , Zuo Zhi‐chao , Zhu Qing‐li , Liu Zhen‐zhen , Wu Sha‐fei , Li Jia‐xin , Du Jian‐hua , Yan Cun‐li , Ma Xiao‐ying , Shi Yue , Shi He , Zhou Yi‐dong , Mao Feng , Lin Yan , Shen Song‐jie , Zhang Xiao‐hui , Sun Qiang 
Published: December 2022

AbstractBackground or PurposeA practical noninvasive method to identify sentinel lymph node (SLN) status in breast cancer patients, who had a suspicious axillary lymph node (ALN) at ultrasound (US), but a negative clinical physical examination is needed. To predict SLN metastasis using a nomogram based on US and biopsy‐based pathological features, this retrospective study investigated associations between clinicopathological features and SLN status.MethodsPatients treated with SLN dissection at four centers were apportioned to training, internal, or external validation sets (n = 472, 175, and 81). Lymph node ultrasound and pathological characteristics were compared using chi‐squared and t‐tests. A nomogram predicting SLN metastasis was constructed using multivariate logistic regression models.ResultsIn the training set, statistically significant factors associated with SLN+ were as follows: histology type (p < 0.001); progesterone receptor (PR: p = 0.003); Her‐2 status (p = 0.049); and ALN‐US shape (p = 0.034), corticomedullary demarcation (CMD: p < 0.001), and blood flow (p = 0.001). With multivariate analysis, five independent variables (histological type, PR status, ALN‐US shape, CMD, and blood flow) were integrated into the nomogram (C‐statistic 0.714 [95% CI: 0.688–0.740]) and validated internally (0.816 [95% CI: 0.784–0.849]) and externally (0.942 [95% CI: 0.918–0.966]), with good predictive accuracy and clinical applicability.ConclusionThis nomogram could be a direct and reliable tool for individual preoperative evaluation of SLN status, and therefore aids decisions concerning ALN dissection and adjuvant treatment.
Comparative Evaluation of Polyphenol Contents and Biological Activities of Five Cistus L. Species Native to Turkey
Authors: Nur Onal Fatma , Ozturk Ismail , Aydin Kose Fadime , Der Gulay , Kilinc Emrah , Baykan Sura 
Published: December 2022

AbstractIn this study phytochemical compounds and antioxidant capacity, cytotoxic, antimicrobial and anti‐biofilm activities of hydroethanolic extracts of five Cistus species (C. creticus L., C. laurifolius L., C. monspeliensis L., C. parviflorus Lam. and C. salviifolius L.) distributed in Turkey were investigated. (+)‐catechin, epigallocatechin gallate, quercetin‐3‐O‐rutinoside, quercetin‐3‐O‐glucoside, kaempferol‐3‐O‐glucoside, luteolin were detected in different amounts. Strongest antioxidant capacities were observed with C. creticus, and C. parvifolius (0.476 and 0.452, respectively). Minimum inhibitory concentrations (MIC) of the extracts were determined between 32 and 128 μg/mL against different bacteria and Candida strains. C. monspeliensis and C. laurifolius extracts were inhibited the biofilm production levels of three Gram‐negative bacteria (E. coli, S. enterica, P. aeruginosa), two Gram‐positive bacteria (S. aureus, B. subtilis) and three Candida strains (C. albicans, C. parapsilosis, C. krusei). C. creticus extract showed strongest cytotoxic activity against human breast adenocarcinoma (MCF‐7) and prostate cell lines (PC‐3) (IC50: 14.04±2.78 μg/mL and 34.04±2.74 μg/mL, respectively) among all plants tested.
Continuous mechanical aspiration thrombectomy performs equally well in main versus branch pulmonary emboli: A subgroup analysis of the EXTRACT‐PE trial
Authors: Leong Derek W. , Ayadi Bahram , Dexter David J. , Rosenberg Michael , Horowitz James M. , Chuang Michael L. , Dohad Suhail 
Published: December 2022

AbstractIntroductionThe EXTRACT‐PE trial evaluated the safety and performance of the Indigo Aspiration System (Penumbra Inc.) with an 8F continuous mechanical aspiration thrombectomy system for the treatment of pulmonary embolism (PE). This subgroup analysis evaluates performance outcomes of patients with main pulmonary artery (PA) emboli versus discrete unilateral or bilateral PA emboli without main PA involvement.MethodsThe EXTRACT‐PE trial was a prospective, single‐arm, multicenter trial that enrolled 119 patients with acute submassive PE. Emboli location was collected at the time of enrollment, CT obstruction was measured and assessed by a Core Lab, and patients were grouped on whether emboli involved the main PA (with or without branch vessels) or not (branch vessels alone). Procedural device time, changes in the right ventricle to left ventricle (RV/LV) ratio, and systolic PA pressure from pre‐and posttreatment were compared between the two groups.ResultsOut of the 119 patients enrolled, 118 had core lab‐assessed clot locations. Forty‐five (38.1%) had emboli that involved the main PA and 73 (61.9%) had only branch emboli. No significant difference was observed between these groups for 30‐day mortality, procedural device time, changes in RV/LV ratio, reduction in CT Obstruction Index, or for systolic PA pressure from pre‐and posttreatment. The mean absolute reduction in clot burden was significant in both groups.ConclusionContinuous mechanical aspiration thrombectomy with the 8F Indigo Aspiration System was effective at improving clinical outcomes for submassive PE patients regardless of emboli location, and clot burden was significantly reduced in both groups.
Influence of the Rare Earth (R) Element in Ru‐supportedRScSi Electride‐like Intermetallic Catalysts for Ammonia Synthesis at Low Pressure: Insight into NH3Formation Mechanism
Authors: Croisé Charlotte , Alabd Khaled , Tencé Sophie , Gaudin Etienne , Villesuzanne Antoine , Courtois Xavier , Bion Nicolas , Can Fabien 
Published: December 2022

AbstractThis study investigates the influence of the rare‐earth (R) element in Ru/RScSi electride‐like intermetallic catalysts for ammonia synthesis under mild conditions (300–450 °C; 1–5 bar). All materials present poor specific surface area and the grain size impacts the ammonia yield. The catalytic performances follow the La to Gd lanthanides series (Ru1.7/LaScSi=Ru1.7/CeScSi=Ru1.7/PrScSi>Ru1.7/NdScSi>Ru1.5/SmScSi>Ru1.3/GdScSi) and appear correlated with the formation of the hydride phase. Ru1.7/CeScSi shows remarkable catalytic activity under moderate condition (0.58 mmolNH3/h/g at 300 °C, 1 bar) associated with its reversible hydrogen storage–release properties. It is evidenced thatRScSi materials assist the N2dissociation in agreement with their electride character and that the hydrogen for NH3formation mainly comes from gaseous hydrogen and not primarily from the hydride phase. It is suggested that NHXformation could be the rate determining step rather than the N2cleavage over these catalysts.
Adsorptive Potential of Orange Peel Biochar for Removal of Basic Red 46 Dye and Phytotoxicity Analysis
Authors: Kapoor Riti Thapar , Sivamani Selvaraju 
Published: December 2022

AbstractThis study assessed the sorption ability of orange peel biochar (OPB) for the removal of Basic Red 46 (BR46) dye. Batch trials were conducted to examine the effects of pH, time, initial dye concentration, dosage, temperature, and particle size on BR46 removal from aqueous solution. Maximum removal by OPB of 94 % was observed at pH 9 and an initial dye concentration of 100 mg L−1. The surface morphology of OPB was characterized by scanning electron microscopy. Equilibrium data were well fitted to the Langmuir model with maximum sorption capacity of 7.36 mg g−1. Adsorption kinetics and thermodynamics revealed a pseudo‐second‐order mechanism, chemisorption, and an exothermic process. Phytotoxicity studies revealed that OPB‐treated effluent can be used for irrigation. Thus, OPB could be a potential adsorbent for BR46 removal.
Computational Fluid Dynamics and Fuzzy Logic for Modeling Conical Spiral Heat Exchangers
Authors: Soltanian Saber , Beigzadeh Reza 
Published: December 2022

AbstractComputational fluid dynamics and fuzzy logic (FL) modeling methods were used to estimate heat transfer and fluid flow characteristics in conical spiral tubes. The effects of coil pitch p and cone angle θ at Reynolds numbers Re of 1500–5500 on flow and heat transfer were investigated. Water with an inlet temperature of 298 K was considered as the working fluid, and a constant wall temperature of 398 K was used in the study. FL was used to predict the Nusselt number and friction factor in conical spiral tubes as functions of Re, θ, and p. FL is an efficient method for predicting complex systems and is a valuable complement to classical hard computing techniques. The purpose of the study was to find a relationship between heat exchanger parameters and performance characteristics. It was also investigated how the FL expert system plays an important role in predicting heat transfer performance.
Oxychalcogenides: A Promising Class of Materials for Nonlinear Optical Crystals with Mixed‐Anion Groups
Authors: Zhang Yujie , Wu Hongping , Hu Zhanggui , Yu Hongwei 
Published: December 2022

AbstractInfrared nonlinear optical (IR NLO) materials are of great significance in the development of IR laser technology. But rationally designing high‐performance IR NLO materials remains a huge challenge due to the conflict between the necessary properties required for NLO materials. Notably, oxychalcogenides with mixed‐anion groups have drawn extensive interest as a family of important IR NLO candidates because they integrate the property advantages of oxides and chalcogenides by chemical substitution engineering. In this review, we provide a survey of reported oxychalcogenides and aim to present the development of NLO oxychalcogenides from the perspective of rational design of their structural chemistry. Furthermore, we focus on the relationships between partial substitution and structural symmetry as well as optical properties. These provide some helpful guidance for the further exploration and design of novel oxychalcogenide materials with excellent NLO performance in the future.
Energy Performance Improvement of a Solar Still System Using Date and Olive Kernels: Experimental Study
Authors: Brihmat Abdeldjabar , Mahcene Hocine , Bechki Djamel , Bouguettaia Hamza , Khechekhouche Abderrahmane , Boughali Slimane 
Published: December 2022

AbstractCurrently, solar distillation systems are used to contribute to solving the fresh water supply deficiency problem in some desert and rural areas. The present outdoor experimental work aims to improve the energy performance of a solar still installed in a semi‐arid region. Experiments are performed using three solar distillers (a reference system, a distiller with date kernels, and one with olive kernels). The integration effect of two kernel types date and olive with different concentrations in the range of 300–600 g kernels per 5 L on the hourly and cumulus water production, and thermal and exergy efficiencies are analyzed. The results show that, for the same kernel mass concentration, the system with olive kernel is more effective than that with date kernels; moreover, compared to the reference system, cumulus water production of these systems at a mass concentration of 500 g kernels per 5 L is higher by ≈226% and 176%, respectively. At a concentration of 500 g kernels per 5 L, the average daily thermal efficiency of the solar still with olive kernels and that with date kernels is 38.01% and 30.7%, respectively, and their daily average exergy efficiency is 8.4% and 3.1%, respectively.
The utility of claudin‐4 versus MOC‐31 and Ber‐EP4 in the diagnosis of metastatic carcinoma in cytology specimens
Authors: Najjar Saleh , Gan Qiong , Stewart John , Sneige Nour 
Published: December 2022

AbstractBackgroundClaudin‐4 is a sensitive and specific marker for carcinoma in effusion cytology. The authors examined the diagnostic use of claudin‐4 versus MOC‐31 and Ber‐EP4 by comparing their sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) in differentiating carcinoma from mesothelioma and benign/mesothelial hyperplasia in effusion specimens.MethodsThis retrospective study comprised a cohort of 229 cytology specimens, including 211 effusion fluid and 18 fine‐needle aspiration specimens. Cytologic categories included 134 carcinoma, 28 mesothelioma, 46 indefinite (suspicious and atypical), and 21 benign. Cell block sections were stained for claudin‐4 and compared with those previously stained for MOC‐31 and Ber‐EP4. Indefinite cases were further reclassified based on clinical and pathologic findings into benign (26 cases), mesothelioma (11 cases), and carcinoma (nine cases).ResultsNone of the mesotheliomas (0/39) or benign effusions (0/47) were positive for claudin‐4, whereas 134 of the 143 carcinoma specimens were positive. Compared to MOC‐31 and Ber‐EP4, claudin‐4 had the highest specificity and PPV (100% for each), followed by Ber‐EP4. Claudin‐4 showed high sensitivity (93.7%), albeit lower than MOC‐31. MOC‐31 had the lowest specificity and PPV but the highest sensitivity and NPV. Ber‐EP4 had the lowest sensitivity (91.6%).ConclusionsClaudin‐4 can be used as a single marker for carcinoma with high sensitivity and superior specificity compared with MOC‐31 and Ber‐EP4. Mesothelial lineage can be ruled out when claudin‐4 is positive. In equivocal cytology samples with few scattered cells of interest, a panel of claudin‐4 and Ber‐EP4 results in the highest combined sensitivity and specificity.
A novel modified tunicate swarm algorithm for optimal charge scheduling and pricing of electric vehicles with user priority‐based charging station selection
Authors: Nair Lakshmi M. , D. M. Mary Synthia Regis Prabha 
Published: December 2022

SummaryIn recent days, electric vehicles (EVs) are seen as a viable transportation alternative by industry people to minimize the greenhouse gas emissions problems of regular fuel vehicles. While EVs' performance is limited due to their restricted battery power, charging wait for service, and high resource costs, they are still a viable option. To enhance the EV's performance, this work introduced an optimized priority‐based charge scheduling with dynamic pricing model. For this, a novel modified tunicate swarm algorithm method, which is the enhanced form of the standard tunicate swarm algorithm, is proposed. When an EV arrives at the charging station, the EV user is permitted to choose the type of charging based on his/her requirements. In general, when charging EVs in public stations or during peak hours, customers must be patient and wait for significant periods of time. The introduced model ignores this negative effect. EV users have also mentioned the issue of controlled charging rates as a key barrier. This is a difficult task, but it is accomplished in this study, which optimizes total charge costs. Finally, the results acquired are discussed under overall cost and energy consumption.