bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPARATIVE EVALUATION OF THE EFFECT OF DIFFERENT ROTARY INSTRUMENT SYSTEMS ON THE AMOUNT OF APICALLY EXTRUDED DEBRIS
Authors: ZAN Recai , LENGER Bilge 
Published: June 2022

Objectives: The purpose of our study is to examine in vitro the amount of debris extrusion from the apical after root canal preparation with different rotary instruments.
Materials and Methods: In present study, 60 single root single-canal lower premolar human teeth were used. The teeth were randomly selected and divided into 4 main groups (n=15). Root canals are shaped by using 2Shape, One Curve and XP-3DEndo Shaper working in rotational motion and WaveOne Gold working reciprocal motion. Later, the weight of each eppendorf tube was weighed on a precision scale and the amount of debris extrusion from the apical was determined with 10ˉ4 precision by subtracting the empty weight of the tube. Since the parametric test assumptions were fulfilled in the evaluation of the data obtained regarding the amount of debris extrusion from the apical of file systems by loading them into the SPSS 22.0 program, One-Way Variance analysis was used and the level of error was taken as 0.05.
Results: When the amount of debris extrusion from the apical is ordered from high to low, it was seen that there are 2Shape, One Curve, XP-Endo Shaper, WaveOne Gold. However, the difference between study groups was not statistically significant (p> 0.05).
Conclusions: Considering the results obtained in terms of debris extrusion from the apical about the new generation files with different metallurgy, kinematics, structural features, designs and different configurations that we used ın present study, it was seen that these systems would not show any difference in terms of the effect of debris on the success of endodontic treatment.
Kvalitativ psykologi som tilfældets psykologi
Authors: Nielsen Klaus 
Published: June 2022

Hensigten for denne artikel er at komme med et bud på, hvad der kendetegner en kvalitativ psykologi. Artiklen tager udgangspunkt i tilfældet, som et centralt erfaringsmæssigt omdrejningspunkt for en kvalitativ psykologi. Tilfældet eller oplevelsen af det tilfældige vil fungere som teoretisk prisme til at reflektere og sammenholde forskellige overvejelser over, hvad en kvalitativ psykologi er for en størrelse og hvilke kritiske potentialer denne tilgang kunne besidde, hvis den blev udviklet yderligere. Det tilfældige kan forstås på mindst tre måder: 1) At noget er en tilfældighed, hvilket vil sige, at det tilfældige betegner her det uforudsete og det uventede. 2) At noget er tilfældet. Her henviser det tilfældige til det konkret eksisterende og enkeltstående. 3) At noget er tilfældigt henviser til et mere grundlæggende organiserende princip for mennesker, handlinger og sociale samspil. Med tilfældet som udgangspunkt formulerer artiklen en kritik af mainstreampsykologiens forståelse af mennesket som et informationsbehandlingssystem, hvor der ikke er plads til den ”anden”, til meningsbegrebet eller til tilfældet. Artiklen diskuterer kort psykologiens replikationskrise som et udtryk for at mainstreampsykologien netop ikke kan undgå at forholde sig til tilfældet eller det tilfældige. Afslutningsvist diskuteres hvad en kvalitative psykologi som tilfældets psykologi kan bidrage med konstruktivt. Her ligger fokus på det social, det konkrete og meningsaspektet.
Den kvalitative psykologiens kraft til å forstyrre fenomenene
Authors: Hogstad Ingrid Johnsen 
Published: June 2022

Psykologisk forskning på mennesket tilbyr selvforståelser som kan fungere selvoppfyllende og dermed være med å (re)produsere de psykologiske fenomenene vi forsker på. Kunnskapsproduksjonen har helt reelle konsekvenser for individ og samfunn, og forskere har et etisk ansvar i å være kritiske i sin forskning og jobbe for å unngå at forskningen skader mennesker, samfunn, natur og miljø. Forfatter av denne artikkelen har tidligere vært opptatt av hvordan psykologisk forskning kan bidra til å reprodusere kunnskap om barns sorg som støtter praksiser som kan fungere ekskluderende for de yngste barna. Denne artikkelen argumenterer for at den kvalitative psykologien bærer i seg en kraft til å «forstyrre» de psykologiske fenomenene vi forsker på heller enn å reprodusere dem, og at denne kraften særlig ligger i analysen og med den i anvendelse av teori. I artikkelen søker forfatteren å demonstrere den forstyrrende kraften i kvalitativ psykologi ved å anvende to ulike teoretisk informerte lesninger av et empirisk eksempel om barns sorguttrykk fra intervjuer med barnehagelærere. De to forskjellige «analytikkene» utvikles fra to ulike teoretiske perspektiver fra utviklingspsykologi, Piagets konstruktivistiske teori om kognitiv utvikling og sosiokulturell utviklingsteori. Lesningene demonstrerer hvordan det teoretiske perspektivet har konsekvenser for hvordan vi avgrenser og lokaliserer psykologiske fenomen, hva vi antar intervjutranskript kan representere av fenomenet og for hva slags kunnskap vi ender opp med å produsere.
Longitudinal Characterization of Vascular Inflammation and Disease Activity in Takayasu Arteritis and Giant Cell Arteritis: ASingle‐CenterProspective Study
Authors: Alessi Hugh D. , Quinn Kaitlin A. , Ahlman Mark A. , Novakovich Elaine , Saboury Babak , Luo Yiming , Grayson Peter C. 
Published: June 2022

ObjectiveTo examine and compare disease activity over time in giant cell arteritis (GCA) and Takayasu arteritis (TAK) using multimodal assessment combining clinical, laboratory, and imaging‐based testing.MethodsPatients with GCA or TAK were enrolled into a single‐center prospective, observational cohort at any point in the disease course. Patients underwent standardized assessment, including18F‐fluorodeoxyglucose positron emission tomography (FDG‐PET) at enrollment and follow‐up visits. Each FDG‐PET finding was subjectively interpreted as active or inactive vasculitis. Global arterial FDG uptake was quantified by the PET Vascular Activity Score (PETVAS). Patients were stratified by disease duration at enrollment (0–2 years; 2–5 years; >5 years). Fisher exact and Mann‐Whitney U tests, Spearman's correlation, and linear regression were used for statistical analyses.ResultsA total of 126 patients with large vessel vasculitis (GCA = 50; TAK = 76) were evaluated across 319 visits. Clinical disease activity was present in 33% of patients in the second to fifth year of disease and in 24% of patients evaluated >5 years after diagnosis. Active vasculitis by PET was observed in 66% of patients in years 2 to 5 after diagnosis and in 50% of patients enrolled >5 years into disease. PETVASs were consistently higher in GCA than TAK in the early and later phases of disease and significantly decreased over time in GCA but not TAK. Correlations between clinical, laboratory, and imaging findings were complex and varied with disease duration.ConclusionDisease activity in GCA and TAK is common throughout the disease course. Patterns of vascular PET activity at diagnosis and later in disease differ between GCA and TAK.
High‐Performance and High‐Stability all‐Polymer Photomultiplication‐Type Organic Photodiode Using an NDI‐Based Polymer Acceptor with Precisely Controlled Backbone Planarity
Authors: Lee Sangjun , Lee Gyeong Seok , Kang Mingyun , Ha Yeon Hee , Kim Yun‐Hi , Chung Dae Sung 
Published: June 2022

AbstractIt is shown that the performance and the operational stability of an all‐polymer photomultiplication‐type organic photodiode (PM‐OPD) can be significantly enhanced by realizing near‐ideal spatial isolation of polymer acceptor via a synthetic approach. A series of new naphthalenediimide‐based D–A polymer acceptors, PNDI–Ph, PNDI–Tol, and PNDI–Xy, with different degrees of backbone planarity are synthesized. By introducing benzene, toluene, and p–xylene as the donor units, increasing intramolecular torsional angle is expected. Thus, 2D grazing‐incidence X‐ray diffraction reveals the highest paracrystalline disorder in the PNDI–Xy thin film. Furthermore, PNDI–Xy has the lowest surface energy resulting in the smallest surface energy difference with matrix donor polymer, poly(3‐hexylthiophene‐diyl) (P3HT). When combined with P3HT, the less aggregated and low surface energy nature of PNDI–Xy results in near‐ideal spatial isolation. Consequently, the all‐polymer PM‐OPD yielded a high external quantum efficiency of 770 000% with specific detectivity of 3.06 × 1013 Jones. The physics behind the success of PNDI–Xy in PM‐OPD is discussed in conjunction with temperature‐dependent current density‐voltage analyses and drift‐diffusion simulations. Furthermore, the use of polymer acceptor enables the resulting PM‐OPD to retain its performance for 24 h, with significantly improved operational stability.
Photothermal‐Amplified Single Atom Nanozyme for Biofouling Control in Seawater
Authors: Wang Wei , Luo Qiang , Li Jinyang , Li Linqian , Li Yunhong , Huo Xiaobing , Du Xiwen , Li Zhongsheng , Wang Ning 
Published: June 2022

AbstractBiofouling is a common and expensive problem in medical, food, and maritime industries. Artificial nanozymes as functional mimics of haloperoxidases that boost the formation of cytotoxic hypohalous acids from halides and H2O2 are showing increasing potential as a novel class of ecofriendly antibiofouling materials to combat biofilm formation. A photothermal nanozyme (Mo SA‐N/C) with Mo single atoms as active sites that exhibits haloperoxidase‐mimicking capacity is herein developed. Density functional theory calculations indicate that hydroxyl radical from H2O2 dissociation is the key intermediate for hypobromous acid formation. Upon photoirradiation, Mo SA‐N/C generates heat and accelerates the reaction kinetics substantially. Finally, it is demonstrated that Mo SA‐N/C exerts superior broad‐spectrum antibacterial activity and can be applied as an effective coating additive for inhibiting biofouling in real marine conditions. Taken together, this study opens an avenue for developing biocompatible and photo‐response artificial enzymes for our fight against marine biofouling.
Maneuvering Applications of Covalent Organic Frameworks via Framework‐Morphology Modulation
Authors: Karak Suvendu , Dey Kaushik , Banerjee Rahul 
Published: June 2022

AbstractTranslating the performance of covalent organic frameworks (COFs) from laboratory to macroscopic reality demands specific morphologies. Thus, the advancement in morphological modulation has recently gained some momentum. A clear understanding of nano‐ to macroscopic architecture is critical to determine, optimize, and improve performances of this atomically precise porous material. Along with their chemical compositions and molecular frameworks, the prospect of morphology in various applications should be discussed and highlighted. A thorough insight into morphology versus application will help produce better‐engineered COFs for practical implications. 2D and 3D frameworks can be transformed into various solids such as nanospheres, thin films, membranes, monoliths, foams, etc., for numerous applications in adsorption, separation photocatalysis, the carbon dioxide reduction, supercapacitors, and fuel cells. However, the research on COF chemistry mainly focuses on correlating structure to property, structure to morphology, and structure to applications. Here, critical insights on various morphological evolution and associated applications are provided. In each case, the underlying role of morphology is unveiled. Toward the end, a correlation between morphology and application is provided for the future development of COFs.
Cold‐Starting All‐Solid‐State Batteries from Room Temperature by Thermally Modulated Current Collector in Sub‐Minute
Authors: Ye Yusheng , Huang Wenxiao , Xu Rong , Xiao Xin , Zhang Wenbo , Chen Hao , Wan Jiayu , Liu Fang , Lee Hiang Kwee , Xu Jinwei , Zhang Zewen , Peng Yucan , Wang Hansen , Gao Xin , Wu Yecun , Zhou Guangmin , Cui Yi 
Published: June 2022

AbstractAll‐solid‐state batteries (ASSBs) show great potential as high‐energy and high‐power energy‐storage devices but their attainable energy/power density at room temperature is severely reduced because of the sluggish kinetics of lithium‐ion transport. Here a thermally modulated current collector (TMCC) is reported, which can rapidly cold‐start ASSBs from room temperature to operating temperatures (70–90 °C) in less than 1 min, and simultaneously enhance the transient peak power density by 15‐fold compared to one without heating. This TMCC is prepared by integrating a uniform, ultrathin (≈200 nm) nickel layer as a thermal modulator within an ultralight polymer‐based current collector. By isolating the thermal modulator from the ion/electron pathway of ASSBs, it can provide fast, stable heat control yet does not interfere with regular battery operation. Moreover, this ultrathin (13.2 µm) TMCC effectively shortens the heat‐transfer pathway, minimizes heat losses, and mitigates the formation of local hot spots. The simulated heating energy consumption can be as low as ≈3.94% of the total battery energy. This TMCC design with good tunability opens new frontiers toward smart energy‐storage devices in the future from the current collector perspective.
Phosphorus and Selenium Co‐Doped WO3 Nanoparticles for Interface Modification and Photovoltaic Properties Enhancement of Monolayer Planar Silicon/PEDOT:PSS Hybrid Solar Cells
Authors: Ni Zitao , Ding Siyu , Zhang Hua , Dai Ruijie , Chen Anran , Wang Rongfei , Zhang Jin , Zhou Yao , Yang Jinpeng , Sun Tao , Hu Guangzhi 
Published: June 2022

AbstractOrganic/silicon hybrid solar cells have attracted extensive attention owing to their low cost and simple manufacturing process. However, theoretical simulations indicate that the efficiency of organic/silicon hybrid solar cells should exceed 20%. This study demonstrates phosphorus and selenium co‐doped WO3 nanoparticles used for heterojunction solar cell (HSC) modification and theoretically elaborates the effects of these doping elements. The doped WO3 nanoparticles are added into poly(3,4‐ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT:PSS) films to optimize the physical properties and qualities of the organic layer. The admixture of P/Se‐WOx greatly improves the open‐circuit voltage and fill factor of Si/PEDOT:PSS solar cell devices. In the hole transport layer (HTL)‐based device, the P/Se‐WOx hybrid PEDOT:PSS HTL yields a power conversion efficiency up to 13.64%, which is substantially higher than those of previously reported undoped and doped devices. The generated W5+ in optimized WO3 further indicates that the VI B group elements, such as W or Mo with 5+ state ions, positively influence the HSC performance and would greatly benefit the photovoltaic industry.
Asymmetric Sequential Vinylogous Mannich/Annulation/Acylation Process of 2‐Ethylidene 1,3‐Indandiones and Isatin N‐Boc Ketimines: Access to Chiral Spiro‐Oxindole Piperidine Derivatives
Authors: Chen I‐Ting , Guan Ren‐You , Han Jeng‐Liang 
Published: June 2022

AbstractA catalytic asymmetric vinylogous Mannich/annulation/acylation reaction of 2‐ethylidene 1,3‐indandiones with isatin N‐Boc ketimines has been developed, which furnished a series of chiral spiro‐oxindole piperidine derivatives with polyaromatic scaffolds in 30–67% yield and 93–98% ee. The DFT computational calculation is used to probe and explain the origin of the enantioselectivity and observed formation of O‐acetylated products.magnified image
Connection, connectivity and choice: Learning during COVID‐19 restrictions across mainstream schools and Flexible Learning Programmes in Australia
Authors: Plage Stefanie , Cook Stephanie , Povey Jenny , Rudling Emily , te Riele Kitty , McDaid Lisa , Western Mark 
Published: June 2022

AbstractThe COVID‐19 pandemic and associated school closures may have constrained educational participation particularly for students in disadvantaged circumstances. We explore how 30 disadvantaged students in secondary school (14 mainstream/16 Flexible Learning Programme) from Queensland, New South Wales and Tasmania experienced home learning during the first wave of COVID‐19, teasing out nuances across two educational models. Drawing on semi‐structured interviews with these students, our analysis revealed three interconnected themes inflecting their learning: connection, connectivity and choice. Connection captures the desire for belonging and practices that facilitated meeting this desire during system‐wide disruptions to school routines and face‐to‐face learning. Connectivity captures the impact of digitally facilitated learning at home on students' ability to engage with curriculum content and with their learning community. Choice captures the availability of viable options to overcome barriers students encountered in their learning and possibilities to flexibly accommodate student preferences and learning needs. Students from Flexible Learning Programmes appeared generally better supported to exercise agency within the scope of their lived experience of home‐based learning. Findings indicate a need for strengthening student‐centred policy and practices aimed at leveraging the affordances of information technology, balancing self‐directed and structured learning and providing holistic support to enable meaningful student choice.
Characterization of a recombinant arginine deiminase from Halothermothrix orenii and its application in citrulline production
Authors: Wang Wenyu , Li Mengli , Miao Ming , Zhang Tao 
Published: June 2022

AbstractIn recent years, arginine deiminase (ADI, EC 3.5.3.6) has attracted much attention as a biocatalyst that produces the functional amino acid l‐citrulline from l‐arginine and also as an anticancer enzyme. Here, we identified and characterized a putative ADI from the thermophilic bacterium Halothermothrix orenii. The H. orenii ADI (H‐ADI) protein was expressed in Escherichia coli BL21(DE3) with a specific activity of 91.8 U/mg protein at 55°C and pH 6.5. The enzyme remained at 74% relative activity after incubation at 45°C for 180 min, only 25% at 50°C. The melting temperature was 56°C. H‐ADI is not a metal‐requiring enzyme; Ni2+ slightly improved the catalytic activity. The Km and Vmax for l‐arginine were 55.5 mM and 156.8 μmol/min/mg protein, respectively. Moreover, three residues (Arg183, Arg237, and His273) were key to the formation of l‐citrulline, as analyzed by alanine‐scanning mutagenesis. Finally, the enzymatic synthesis of l‐citrulline was carried out at 50°C with a conversion ratio reaching 99.03%. Together, these findings show that H‐ADI is a promising biocatalyst for the production of l‐citrulline.
Associations of the A118G OPRM1 polymorphism with sociotropy and interpersonal sensitivity
Authors: Suzuki Akihito , Shirata Toshinori , Noto Keisuke , Matsumoto Yoshihiko , Muraosa Haruka , Abe Mio , Goto Kaoru , Otani Koichi 
Published: June 2022

AbstractBackgroundThe μ‐opioid receptor (MOR) plays an important role in social bonding behaviors, while it is implicated in the pathophysiology of depression. It is shown that the A118G polymorphism (rs1799971) of the MOR gene (OPRM1) causes amino‐acid exchange from Asn to Asp, and that this polymorphism is associated with altered mu‐opioid receptor function. Meanwhile, sociotropy/autonomy and interpersonal sensitivity are personality vulnerabilities to depression characterized by distinctive interpersonal styles. The present study tested the hypothesis that the functional A118G OPRM1 polymorphism influences these personality traits.MethodsThe subjects were 402 physically and mentally healthy Japanese volunteers. Sociotropy and autonomy were measured by the Sociotropy‐Autonomy Scale, and interpersonal sensitivity was evaluated by the Interpersonal Sensitivity Measure. The A118G polymorphism of the OPRM1 was determined by the PCR method.ResultsIn one factor analysis of covariance, there were differences in scores of sociotropy (uncorrected p < .001, corrected p < .003) and interpersonal sensitivity (uncorrected p = .015, corrected p = .045), but not autonomy, among the A/A, A/G, and G/G genotypes. Post hoc LSD tests showed that sociotropy scores were higher in the A/A group than in the A/G (p = .029) and G/G (p < .001) groups, and higher in the A/G group than in the G/G group (p = .004). Interpersonal sensitivity scores were higher in the A/A group than in the A/G (p = .023) and G/G (p = .009) groups.ConclusionThis study suggests that the A118G OPRM1 polymorphism is associated with sociotropy and interpersonal sensitivity, interpersonal vulnerabilities to depression.
Examining the effect of feedback type and gender on computing achievements, engagement, flipped learning readiness, and autonomous learning in online flipped classroom
Authors: Polat Elif , Hopcan Sinan , Albayrak Ebru , Yildiz Durak Hatice 
Published: June 2022

AbstractThe purpose of this study was to examine how the flipped learning readiness, engagement, autonomous learning, and computing achievements of university students in an online flipped classroom differ according to gender and feedback groups (verbal, written, and grade reporting) before and after a computing course. An 8‐week application was conducted with 104 university students enrolled Computing course at a state university, İstanbul, Turkey. Students were randomly assigned to three different feedback groups. An experimental design was used in this study and quantitative data was collected. Students did homework and written/verbal or grade feedback was given to students through Moodle. A flipped learning readiness scale, computing achievement test, online student engagement scale, and autonomous learning scale were given to participants as pretests and posttests. The results showed that computing academic achievement, flipped learning readiness, and engagement variables increased significantly. There were differences in online engagement regarding gender but no difference between feedback types. The research includes suggestions for future studies.
Oncolytic adenovirus H101 ameliorate the efficacy of anti‐PD‐1 monotherapy in colorectal cancer
Authors: Huang Lili , Zhao Huaxin , Shan Mengying , Chen Hong , Xu Bin , He Yang , Zhao Yu , Liu Zhuqing , Chen Jianhua , Xu Qing 
Published: June 2022

AbstractBackgroundImmune checkpoint blockade therapy with anti‐programmed cell death (PD)‐1 antibodies provides therapeutic effect for many patients of various cancers but remains inadequate in colorectal cancer (CRC) patients. The present study aims to assess the efficacy of oncolytic adenovirus (OncoAd) in enhancing the anti‐PD‐1 treatment of CRC.MethodsThe estimating relative subsets of RNA transcripts algorithm was used for estimating the infiltrated immune cells in melanoma and CRC tissues. The efficacy of OncoAd with anti‐PD‐1 monotherapy was performed in a CT26 CRC mouse model in vivo. Flow cytometric analysis of peripheral blood and tumor tissues determined the difference anti‐tumor immune efficacy of OncoAd with anti‐PD‐1 monotherapy.ResultsThe Cancer Genome Atlas database indicated that CD8+ T cells and regulatory T cells were significantly elevated in melanoma compared to CRC cohorts. Moreover, intratumor injection of oncolytic adenovirus enhanced T cell infiltration and decreased Treg percentages in the CT26 CRC colorectal cancer mouse model. Combinatorial OncoAd with anti‐PD‐1 antibody treatment markedly enhanced the anti‐tumor efficacy of anti‐PD‐1 by significantly decreasing the tumor volume and reducing tumor growth in a CRC mouse model. To the end, OncoAd treatment increased the CD8/Treg ratio, indicating that OncoAd intratumor injection ameliorate the anti‐tumor immune response of anti‐PD‐1 therapy.ConclusionThe present study elucidates that OncoAd promotes intratumor T cell infiltration and improves anti‐PD‐1 immunotherapy, thereby providing a potent combinatorial therapeutic strategy for CRC.