bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early combination therapy with immunoglobulin and steroids is associated with shorter ICU length of stay in Multisystem Inflammatory Syndrome in Children (MIS‐C) associated with COVID‐19: A retrospective cohort analysis from 28 U.S. Hospitals
Authors: Harthan Aaron A. , Nadiger Meghana , McGarvey Jeremy S. , Hanson Keith , Gharpure Varsha P. , Bjornstad Erica C. , Chiotos Kathleen , Miller Aaron S. , Reikoff Ronald A. , Gajic Ognjen , Kumar Vishakha , Walkey Allan J. , Kashyap Rahul , Tripathi Sandeep ,   Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID‐19 Registry Investigator Group
Published: June 2022

AbstractObjectivesSuggested therapeutic options for Multisystem Inflammatory Syndrome in Children (MIS‐C) include intravenous immunoglobulins (IVIG) and steroids. Prior studies have shown the benefit of combination therapy with both agents on fever control or the resolution of organ dysfunction. The primary objective of this study was to analyze the impact of IVIG and steroids on hospital and ICU length of stay (LOS) in patients with MIS‐C associated with Coronavirus Disease 2019 (COVID‐19).Study DesignThis was a retrospective study on 356 hospitalized patients with MIS‐C from March 2020 to September 2021 (28 sites in the United States) in the Society of Critical Care Medicine (SCCM) Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS) COVID‐19 Registry. The effect of IVIG and steroids initiated in the first 2 days of admission, alone or in combination, on LOS was analyzed. Adjustment for confounders was made by multivariable mixed regression with a random intercept for the site.ResultsThe median age of the study population was 8.8 (Interquartile range (IQR) 4.0, 13) years. 247/356 (69%) patients required intensive care unit (ICU) admission during hospitalization. Overall hospital mortality was 2% (7/356). Of the total patients, 153 (43%) received IVIG and steroids, 33 (9%) received IVIG only, 43 (12%) received steroids only, and 127 (36%) received neither within 2 days of admission. After adjustment of confounders, only combination therapy showed a significant decrease of ICU LOS by 1.6 days compared to no therapy (exponentiated coefficient 0.71 [95% confidence interval 0.51, 0.97, p = 0.03]). No significant difference was observed in hospital LOS or the secondary outcome variable of the normalization of inflammatory mediators by Day 3.ConclusionsCombination therapy with IVIG and steroids initiated in the first 2 days of admission favorably impacts ICU but not the overall hospital LOS in children with MIS‐C.
Examining the implementation of Teacher–Child Interaction Training‐Universal in public schools
Authors: Santiago Catherine DeCarlo , Bustos Yvita , Sosa Susana S. , Jolie Sarah A. , Flores Toussaint Roxanna , Gebhardt Sarah , Stern David , Budd Karen S. 
Published: June 2022

AbstractThe Teacher–Child Interaction Training‐Universal (TCIT‐U) is a professional development program for teachers that promotes positive relational interactions and strengthens classroom management. This study examines the implementation of TCIT‐U in a public school district to guide future implementation and sustainability. This study uses qualitative methods to examine the implementation of TCIT‐U across preschool through second‐grade classrooms in a suburban public school district in Illinois, United States. Eight teachers and five coaches participated in focus groups, while three administrators completed interviews. Qualitative data from focus groups and interviews are supplemented by quantitative data on satisfaction, teacher sense of efficacy, teacher observations, and school records. Results demonstrated high levels of acceptability, good feasibility, high satisfaction, and several notable improvements across teachers and students, such as improved teachers' confidence and self‐efficacy in managing classrooms. Nevertheless, there were implementation challenges, including timing, competing demands, and district priorities. The results from this study offer guidance for future implementation of TCIT‐U as an acceptable, feasible, and universal intervention.
Surgery to restore upper extremity function in tetraplegia—Preferences for early and frequent access to information
Authors: L'Hotta Allison J. , James Aimee S. , Curtin Catherine M. , Kennedy Carie , Kenney Deborah , Tam Katharine , Ota Doug , Stenson Katherine , Novak Christine B. , Fox Ida K. 
Published: June 2022

AbstractIntroductionPeople with cervical spinal cord injury (SCI) identify improving upper extremity (UE) function as a top priority. In addition to comprehensive rehabilitation, UE surgeries, including nerve and tendon transfers, enhance function. However, barriers exist to disseminating information about surgical options to enhance UE function.ObjectiveTo assess the experiences and preferences of people with cervical SCI and their caregivers in accessing information about surgery to enhance UE function.DesignProspective cohort study. Participants were followed up for 24 months and completed up to three interviews.SettingTertiary care at academic and affiliated Veterans Administration Health Care Centers.ParticipantsAdults with cervical SCI (n = 35) ages 18 to 80 years with mid‐cervical SCI American Spinal Injury Association Impairment Scale A, B, or C (at least 6 months post‐injury) and their caregivers (n = 23) were eligible to participate. Participants were enrolled in three groups: nerve transfer, tendon transfer, or no UE reconstructive surgery.InterventionsNot applicable.Main Outcome MeasureSemi‐structured interviews about surgical knowledge and experiences.ResultsData were analyzed and three themes were identified. First, providing information about UE surgical options early post‐injury was recommended. The acute or inpatient rehabilitation phases of recovery were the preferred times to receive surgical information. Second, challenges with information dissemination were identified. Participants learned about UE surgery through independent research, medical provider interactions, or peers. Third, peers were identified as valuable resources for SCI needs and surgical information.ConclusionsFollowing cervical SCI, information about UE reconstructive surgeries should be a standard component of education during rehabilitation. An increased understanding of the reconstructive options available to improve UE function is necessary to educate stakeholders. Future research is needed to support the development of strategies to effectively present surgical information to individuals with SCI and health care providers.
Death anxiety as general factor to fear of cancer recurrence
Authors: Berlin Pia , von Blanckenburg Pia 
Published: June 2022

AbstractObjectiveFear of cancer recurrence or progress is strongly related to death anxiety (DA) in cancer patients, but due to lack of conceptualization and measurement methods, the relationship was not analyzed quantitatively before. The aim of the present study was to investigate the conceptual relationship of both constructs, with DA expected to be the general construct.MethodsCancer patients (N = 121) participated in an online study. They provided information on socio‐demographical, medical and psychological measures including DA and fear of cancer recurrence or progression (FoP‐Q‐SF). Relation of constructs was assessed using a two‐step process: Confirming individual construct structure with confirmatory factor analysis, including correlation of constructs and modification of measurement model, followed by structural equation modeling and comparison of structure models for best model fit.ResultsThe measurement model was modified to include three residual correlations within and between constructs. Comparison of structure models supported a bifactor structure with DA as general factor and fear of recurrence or progression as group factor: SBχ2 (173) = 207.74 (p < 0.05), SB = 1.538, relative χ2 = 1.2, rRMSEA = 0.05 [0.01, 0.07] (p > 0.05), SRMR = 0.07, CFI = 0.94, AIC = 7543.60.ConclusionsDA can be interpreted as general factor to fear of cancer recurrence or progression. Psychological interventions to reduce emotional burden of cancer patients need to focus additionally on existential threat and individual fears regarding DA.
Posterior tracheopexy for preterm infants with severe bronchopulmonary dysplasia and severe tracheobronchomalacia: A case series
Authors: Enzer Katelyn G. , Wine Todd M. , Gien Jason , Somme Stig , Prager Jeremy D. , Baker Christopher D. 
Published: June 2022

AbstractWe report a series of four patients with severe bronchopulmonary dysplasia (BPD) who underwent posterior tracheopexy for severe tracheomalacia (TM). While posterior tracheopexy is an established surgical treatment for TM associated with tracheoesophageal fistula, it has not been previously described in TM associated with BPD. There were no significant intraoperative or postoperative complications from the surgeries. Three of the four patients required tracheostomy and mechanical ventilation, which may reflect the degree of lung disease and other multisystem comorbidities in these patients. More investigation is needed to determine whether posterior tracheopexy is an effective surgical option for TM related to BPD.
Oxygen Vacancy Induced Boosted Visible‐Light Driven Photocatalytic CO2 Reduction and Electrochemical Water Oxidation Over CuCo‐ZIF@Fe2O3@CC Architecture
Authors: Zhang Na , Zhang Qing , Zhang Lin‐Yan , Zhang Jian‐Yong , Fang Yong‐Zheng , Liu Zhifu , Zhou Min 
Published: June 2022

AbstractHerein, the obtained Cu0.5Co0.5‐ZIF@Fe2O3@CC‐150 heterojunction (termed as Cu1‐xCox‐ZFC‐150) showed high hydrogen and oxygen evolution reaction (HER and OER) activities with low overpotential small Tafel slope. When employed to be the bifunctional anode and cathode, they only needed a cell voltage of 1.62 V. The composite also exhibited excellent photocatalytic performance on CO2 evolution into CO and CH4. The enhanced OER kinetics and Z‐scheme charge transfer model for photocatalytic property have been discussed based on the experiments and density functional theory (DFT) analysis. The optimized phase interfaces, abundant active sites, optional oxygen vacancy, and adjusted Gibbs free energy were beneficial for the fast electron/ion transport enhancing the water splitting performance.
Reviewing the impact of digital migration on the consumer buying journey with robust measurement of PLS‐SEM and R Studio
Authors: Nayyar Varun 
Published: June 2022

AbstractCurrent research has contributed to multiple relationship marketing models with digital migration, while studying multiple mediation effects of constructs like customer review, media mix and redesigned consumer journey, to develop a promising approach that will help to understand changing consumer preferences. By using PLS‐SEM and R studio, this research contributed to multiple relationship marketing models where different robust measuring standards of PLS‐SEM like multicollinearity, average variance, composite reliability, discriminant validity, endogeneity, R2 and IPMA helped in idealising marketing model assessment and fitness. Research findings indicate that with dynamism in consumer preferences, firms indeed have to redesign their marketing models with a focused ideology, reflecting the trend of digital migration with respect to media mix, customer review and a redesigned consumer journey for their final consumption behaviour. Government who were not near a digital platform needed to innovate their working style by improving their digital infrastructure and making digitization easier for consumers.
Insect and Pathogen Influences on Tree-Ring Stable Isotopes
Authors: Ulrich Danielle E. M. , Voelker Steve , Brooks J. Renée , Meinzer Frederick C. 
Published: June 2022

AbstractUnderstanding long-term insect and pathogen effects on host tree physiology can help forest managers respond to insect and pathogen outbreaks, and understand when insect and pathogen effects on tree physiology will be exacerbated by climate change. Leaf-level physiological processes modify the carbon (C) and oxygen (O) stable isotopic composition of elements taken up from the environment, and these modifications are recorded in tree-rings (see Chaps. 10.1007/978-3-030-92698-4_9, 10.1007/978-3-030-92698-4_10, 10.1007/978-3-030-92698-4_16 and 10.1007/978-3-030-92698-4_17). Therefore, tree-ring stable isotopes are affected by both the tree’s environment and the tree’s physiological responses to the environment, including insects and pathogens. Tree-ring stable isotopes provide unique insights into the long-term effects of insects and pathogens on host tree physiology. However, insect and pathogen impacts on tree-ring stable isotopes are often overlooked, yet can substantially alter interpretations of tree-ring stable isotopes for reconstructions of climate and physiology. In this chapter, we discuss (1) the effects of insects(defoliators, wood-boring, leaf-feeding), pests (parasitic plants), and pathogens(root and foliar fungi) on hostphysiology (growth, hormonal regulation, gas exchange, water relations, and carbon and nutrient use) as they relate to signals possibly recorded by C and O stable isotopes in tree-rings, (2) how tree-ring stable isotopes reveal insect and pathogen impacts and the interacting effects of pathogens and climate on hostphysiology, and (3) the importance of considering insect and pathogen impacts for interpreting tree-ring stable isotopes to reconstruct past climate or physiology.
Anatomical, Developmental and Physiological Bases of Tree-Ring Formation in Relation to Environmental Factors
Authors: Rathgeber Cyrille B. K. , Pérez-de-Lis Gonzalo , Fernández-de-Uña Laura , Fonti Patrick , Rossi Sergio , Treydte Kerstin , Gessler Arthur , Deslauriers Annie , Fonti Marina V. , Ponton Stéphane 
Published: June 2022

AbstractUnderstanding the process of wood formation and its dynamics over the growing season is fundamental to interpret the isotopic signature of tree rings. Indeed, the isotopic signal recorded in wood does not only depend on the conditions influencing carbon, water, and nitrogen uptake in the leaves and roots, but also on how these elements are translocated to the stem and incorporated into the developing xylem. Depending on environmental conditions, tree developmental stage, and physiological status, wood formation dynamics can vary greatly and produce tree-ring structures carrying specific isotopic signatures. In this chapter, we present the physiological processes involved in wood formation, along with their relationships with anatomical, developmental, and environmental factors, to understand when and how photosynthetic assimilates are progressively incorporated into the forming xylem, creating the final isotopic signature of a tree ring. First, we review current knowledge on the structure and functions of wood. Then we describe the xylogenesis process (how and when the new xylem cells produced by the cambium develop through successive differentiation phases), and its relationships with physiological, developmental, and environmental factors. Finally, we explain the kinetics of xylemcell differentiation and show why the knowledge recently acquired in this field allows us to better understand the isotopic signals in tree rings.
Research Interest
Authors: Modica Marcello 
Published: June 2022

AbstractThe occurrence of industrial brownfield sites in mountain regions is emerging as a key spatial development challenge. The European Alps offer a privileged case study area in this regards due to their high level of industrial maturity and the clear evidences of an ongoing structural change. The difference between urban and mountain brownfields seems to lie not much in the content of the sites, which is indeed functionally related to certain industries and processes, but more on the physical and non-physical relationships with the context. The misunderstanding of these specific conditions leads often to incomplete or even failed transformation attempts, as proved by few examples of the two recurring strategies implemented in the Alps: building recycling and land recycling. An alternative approach capable of highlighting and enhancing the infrastructural specificity of mountain brownfields, based on an holistic understanding of landscape, might help to overcome the existing planning and management shortcomings.
The Alps as context
Authors: Modica Marcello 
Published: June 2022

AbstractThe Alps provide all the relevant conditions for studying the occurrence of brownfields in mountain settings, from the advanced socio-economic structure which enables deindustrialization to the high development pressure that sets context-related transformation objectives. Through a detailed geo-economic analysis of past Alpine industrialization and the late structural change, the source and types of mountain brownfields are first identified. On this basis, and having always the specificity of the Alpine context as reference, the challenges and potentials of brownfield redevelopment are then explained through the lens of economy, society and environment. This review ultimately helps to frame mountain brownfields as a unique territorial capital for regional development, as well as a space of possibility firmly embedded in the cultural landscape.
Characterising
Authors: Modica Marcello 
Published: June 2022

AbstractBased on the mapping results, the characterisation phase focuses on the most representative site typologies of Alpine brownfields. These are identified and analysed according to a structural criterion, which emphasises the role of previous industry-environment interactions as generator of a specific and recurring landscape structure. Through a comparative analysis of aerial views and self-generated figure-ground diagrams, four representative site typologies are selected and described on the basis of their recognisable structural features and their inherent transformation potential.
Testing
Authors: Modica Marcello 
Published: June 2022

AbstractThe testing phase involves four case study sites selected from the previously outlined geography of Alpine brownfields as a ‘test base’ for developing a landscape-oriented transformation model. By means of a detailed research protocol, which includes and integrates intensive fieldwork activities and interpretative background analysis, the sites are gradually unveiled as highly representative situations of the vast case systems of Alpine brownfields. Based on concrete and reality-matching inputs from local stakeholders and communities, each site’s transformation is then ‘virtually’ realized through speculative design explorations. This allows not only to outline a specific planning approach to transformation itself, but also it helps to identify and categorise all those possible interventions that can be implemented.
Research Outcomes
Authors: Modica Marcello 
Published: June 2022

AbstractThe main research outcomes are presented and discussed with reference to the research aims, hypothesis and by considering the preliminary results of the three analytical phases. The holistic landscape approach applied to the transformation of Alpine brownfields is defined through its characterising aspects, effectiveness and rendered into a clear operational/procedural structure. A particular emphasis is given to the three-system strategy designed to guide the site transformation itself. In conclusion, the overall transferability and replicability of the proposed approach is discussed with reference to the analytical levels of the research (regional types, landscape structures, intervention taxonomy).
CP-violating 2HDMs emerging from 3-3-1 models
Authors: Fan Zhiyi , Yagyu Kei 
Published: June 2022

Abstract
We investigate CP violating 2 Higgs doublet models as an effective theory emerging from models with an SU(3)L ⊗ U(1)X gauge symmetry. Because of the extension of the electroweak symmetry, a characteristic structure of Yukawa interactions appears with new CP violating phases at the electroweak scale. In this scenario, the charged Higgs boson loop provides dominant and sizable contributions to the neutron electric dipole moment (nEDM) at one-loop level. We find that the prediction of the nEDM can be slightly smaller than the current upper limit, $$ \mathcal{O} $$
O
(10−26) e cm, with the mass of the charged Higgs boson and new CP violating phases to be a few hundred GeV and $$ \mathcal{O} $$
O
(1), respectively, under the constraints from the meson mixings, the B → Xsγ decay and current LHC data.
Sphere theorems with and without smoothing
Authors: Deng Jialong 
Published: June 2022

AbstractWe show two sphere theorems for the Riemannian manifolds with scalar curvature bounded below and the non-collapsed $$\mathrm {RCD}(n-1,n)$$

RCD
(
n
-
1
,
n
)

spaces with mean distance close to $$\frac{\pi }{2}$$

π
2

.
Gendered university major choice: the role of intergenerational transmission
Authors: Philipp Julia 
Published: June 2022

AbstractIn this paper, I study the role of gender-typical parental occupation for young adults’ gender-typical university major choice using data on a recent cohort of university students in Germany. Results show significant intergenerational associations between the gender typicality in parental occupation and young adults’ majors. As to why these effects occur, findings suggest that the transfer of occupation-specific resources from parents to their children plays an important role and that a transmission of gender roles explains at least some of the father-son associations. The paper contributes to existing literature by introducing a novel measure that operationalises the extent to which majors and occupations are ‘typically female’ or ‘typically male’ and by studying different transmission channels.
Mouse models in COVID-19 research: analyzing the adaptive immune response
Authors: Clever Sabrina , Volz Asisa 
Published: June 2022

AbstractThe emergence of SARS-CoV-2, the severe acute respiratory syndrome coronavirus type 2 causing the COVID-19 pandemic, resulted in a major necessity for scientific countermeasures. Investigations revealing the exact mechanisms of the SARS-CoV-2 pathogenesis provide the basis for the development of therapeutic measures and protective vaccines against COVID-19. Animal models are inevitable for infection and pre-clinical vaccination studies as well as therapeutic testing. A well-suited animal model, mimicking the pathology seen in human COVID-19 patients, is an important basis for these investigations. Several animal models were already used during SARS-CoV-2 studies with different clinical outcomes after SARS-CoV-2 infection. Here, we give an overview of different animal models used in SARS-CoV-2 infection studies with a focus on the mouse model. Mice provide a well-established animal model for laboratory use and several different mouse models have been generated and are being used in SARS-CoV-2 studies. Furthermore, the analysis of SARS-CoV-2-specific T cells during infection and in vaccination studies in mice is highlighted.