bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of intravenous contrast substance administration on intraocular pressure, tear amount and oxidative stress in rats
Authors: CELLAT Mustafa , İŞLER Cafer Tayer 
Published: August 2022

Although iodinated radiocontrast agents, which are frequently used in radiological procedures such as indirect radiography, angiography, intravenous urography and computed tomography, are generally safe, they can cause serious side effects. In this study, it was aimed to investigate the effect of intravenous ionic high osmolar contrast agent administration on intraocular pressure, tear amount and oxidant and antioxidant parameters of eye tissue. Study groups consisted of 2 groups, Group 1 (Control) and Group 2 (Urographin), and a total of 16 Wistar albino female rats were used. On the first day of the experiment, 6 ml/kg of physiological saline was administered intravenously to the control group, and the same dose of contrast agent was administered to group 2. Intraocular pressure and tear amounts were measured at 1, 6, 12, 24 and 48 hours after intravenous administration. After measurements were made at the 48th hour of the experiment, all rats were euthanized and their eye tissues were removed. In order to reveal the oxidative damage and antioxidant activity in the eye tissue, malondialdehyde and reduced glutathione levels, catalase and glutathione peroxidase enzyme activities were measured spectrophotometrically. Schimer tear test (STT-1) strip was used for tear amount measurements, and rebound tonometer Tonovet® was used as tonometer for intraocular pressure measurements. No statistically significant difference was found between the control and urographin groups in terms of intraocular pressure and tear amounts in the measurements performed at 1,6,12,24 and 48th hours after urographin administration. It was observed that the same application significantly increased the malondialdehyde level (P&lt;0.005) in the eye tissue. There was no significant difference between the groups in terms of reduced glutathione level and catalase and glutathione peroxidase enzyme activities in eye tissue. It was evaluated that intravenous contrast agent administration causes oxidative stress in the eye tissue and this may have a long-term ocular effect
Dessensibilização oncológica em hemato-oncologia e o papel do enfermeiro: estudo de caso
Authors: Gaspar Cláudia , Dias Ortélia , Frias Sónia 
Published: August 2022

Associado ao aparecimento de novas armas terapêuticas e à maior sobrevivência dos doentes oncológicos, verifica-se um aumento da incidência de reações adversas à quimioterapia.
A Reação de Hipersensibilidade (RHS) é descrita como uma reação adversa a fármacos imprevisível e dose-independente, e pode ser classificada em leve, moderada, grave ou fatal, de acordo com a sintomatologia do doente.
Perante uma RHS a fármacos antineoplásicos, os doentes hemato-oncológicos eram privados do tratamento de eleição. Atualmente, a Dessensibilização Oncológica (DO) surge como a estratégia terapêutica que permite a reintrodução do tratamento de eleição, de forma segura e eficaz, traduzindo-se numa nova esperança para esses doentes. Com o objetivo de demonstrar a importância do papel do Enfermeiro junto do doente a realizar DO, apresentamos o caso de uma jovem de 22 anos de idade com o diagnóstico de Linfoma de Hodgkin, com hipersensibilidade a um fármaco antineoplásico e quecumpriu o protocolo de DO com sucesso.
Relationship Of Knowledge On Community Behavior In Eradication Of Aedes Aegypti Mosquito Nests In The Work Area Of Pal. 3 Puskesmas Pontianak
Authors: Kastari Salbiah , Susilawati Susilawati , Iswono Iswono 
Published: August 2022

Dengue Hemorrhagic Fever (DHF) is transmitted through the bite of the Aedes aegypti mosquito and possibly the Aedes albopictus mosquito. The incidence of DHF in Indonesia in the last 3 years of 2018 was 65,602 cases, in 2019 as many as 138,127 cases, and in 2020 as many as 108,303 cases. In West Kalimantan, in 2018, as many as 3,125 cases, in 2019 as many as 2,798 cases, and in 2020 as many as 784 cases. Meanwhile, data on dengue cases in Pontianak City, in 2018 there were as many as 182 cases, in 2019 there were as many as 106 cases, and in 2020 there were as many as 27 cases. Nationally, cases of DHF fluctuate, while in West Kalimantan to Pontianak, it tends to decrease. The death rate (CFR) due to DHF cases in Pontianak City during the period 2018-2019 showed the highest mortality rate occurred in 2018 with a percentage of 1,54% of 100 DHF cases. However, the incidence rate is still there, and every year (endemic) and always has the potential to cause outbreaks. Therefore, efforts to control mosquitoes carrying dengue disease are needed, starting by assessing community knowledge and behavior in controlling DHF disease with nest eradication. Mosquitoes (PSN 3M plus). Objective To examine the relationship between knowledge and community behavior in PSN 3M plus in the work area of ​​the Pal.3 Pontianak Health Center. Methodology is observational research with a cross-sectional approach. The results of the study showed that there was a significant relationship between knowledge and PSN 3M plus in the work area of ​​the Pontianak Pal.3 Health Center, with a value of p = 0.000 (p<). Most respondents have poor knowledge in PSN 3M plus (61,7%), as well as bad behavior in PSN 3M plus (77,7%), so it is concluded that there is a significant relationship between respondents' knowledge and behavior in PSN 3M Plus in the work area of ​​the Pontianak Pal. 3 Health Center.
Analisis Bauran Pemasaran Terhadap Tingkat Penjualan (Studi Home Industry Roti Al Mustofa di Metro
Authors: Wariyanti Susi , Liberty Liberty , Imtihanah Ani Nurul 
Published: August 2022

AbstrakTujuan penelitian ini yaitu untuk melihat bagaimana bauran pemasaran dalam meningkatan penjualan pada home industry Roti Al Mustafa. Jenis penelitian ini yaitu penelitian lapangan (field research) dengan data-data yang dikumpulkan melalui wawancara dan dokumentasi. Teknik analisis data yang digunakan bersifat desktiptif-kualitatif melalui metode berfikir induktif, yaitu berpikir dari khusus ke umum yang berangkat dari informasi tentang bauran pemasaran pada home industry roti Al Mustafa. Hasil penelitian menunjukkan bahwa home industry roti Al Mustafa telah menerapkan strategi bauran pemasaran melalui 4P yaitu dari segi produk dan harga roti Al Mustafa menciptakan produk yang berkualitas dengan harga yang terjangkau sehingga mampu menarik minat konsumen untuk melakukan pembelian ulang yang berimbaas pada peningkatan penjualan pada setiap varian roti. Dari segi tempat/saluran distribusi, dengan cakupan wilayah distribusi seperti Metro, Trimurjo, Punggur, Pekalongan dan Bandar Jaya sehingga belum mampu meningkatkan penjualan secara maksimal dikarenakan kurangnya perluasan wilayah pemasaran yang masih terfokus pada sekolah dan warung-warung. Dan dari segi promosi, roti Al Mustafa masih menggunaka sistem promosi yang sederhana yaitu melalui metode mulut ke mulut
Kata kunci: Bauran Pemasaran, Penjualan, Home Industry
AbstractThe purpose of this study is to see how the marketing mix in increasing sales at the Al Mustafa Bread home industry. This type of research is field research with data collected through interviews and documentation. The data analysis technique used is descriptive-qualitative through the method of inductive thinking, namely thinking from specific to general which departs from information about the marketing mix in the Al Mustafa bakery home industry. The results showed that the Al Mustafa bakery home industry has implemented a marketing mix strategy through 4P, namely in terms of products and prices of Al Mustafa bread, creating quality products at affordable prices so that they are able to attract consumers to make repeat purchases which lead to increased sales in each variant. bread. In terms of distribution places / channels, with coverage of distribution areas such as Metro, Trimurjo, Punggur, Pekalongan and Bandar Jaya so that they have not been able to increase sales maximally due to the lack of expansion of the marketing area which is still focused on schools and shops. And in terms of promotion, Al Mustafa bread still uses a simple promotion system, namely through the word of mouth method.
Keywords: Marketing Mix, Sales, Home Industry
Strategi Pemasaran dalam Meningkatkan Pendapatan Pada Industri Kriya Souvenir Khas Lampung )
Authors: Nuriasari Selvia , Mahfudzoh Siti , Dewichan Sukma Sari 
Published: August 2022

Istana Seni adalah satu-satunya produsen kriya souvenir khas Lampung di Kota Metro yang bertahan lebih dari sepuluh tahun. Rata-rata pertumbuhan Pendapatan produk kriya Istana Seni tahun 2016 hingga 2018 cenderung fluktuatif menurun kecuali tahun 2017 yang naik sebesar 14.51%. Adapun pertumbuhan Pendapatan Istana Seni secara berturut-turut adalah dari 11.25%, 14.51% dan 12.18%. Artinya pada akhir tahun 2018, turun dibandingkan tahun sebelum. Untuk mengantisipasi terjadinya penurunan pendapatan di tahun 2019, Istana Seni mereformulasi strategi pemasaran yang tepat dengan menfokuskan pada bauran pemasaran. Untuk menganalisa penerapan strategi pemasaran tersebut, peneliti menggunakan etika pemasaran Islami.
Penelitian ini merupakan penelitian lapangan dengan sifat kualitatif deskriptif dengan mendeskripsikan data di lapangan melalui wawancara dan dokumentasi untuk mengetahui formulasi strategi pemasaran dengan menfokuskan bauran pemasaran yang digunakan Istana Seni untuk meningkatkan trend pendapatan. Untuk itu, peneliti mewawancarai Jalius sebagai pemilik, karyawan Istana Seni dan pembeli untuk mendapatkan gambaran mengenai formulasi strategi pemasaran yang didukung dokumen seperti data pendapatan selama beberapa tahun terakhir.
Hasil dari penelitian ini adalah Istana Seni menggunakan bauran pemasaran 7 P untuk meningkatkan pendapatan industri kriya Istana Seni. Adapun bauran pemasaran yang digunakan adalah product, price, place, promotion, process, people dan physical evidence, dengan titik fokus pada tiga bauran pemasaran yaitu bauran produk, bauran harga dan bauran promosi. Hasil yang dicapai adalah trend pendapatan di akhir tahun 2019 meningkat tipis. Ditinjau dari prinsip pemasaran Islami, maka penerapan strategi pemasaran telah sesuai.
A Systematic Review of Factors Associated with Special Education Teacher Recruitment
Authors: Hobson Jarrod 
Published: August 2022

Addressing teacher shortage is a current and long-standing critical need in special education. Additionally, the current teacher workforce is not as diverse as the current student population. Nationwide, there continues to be a heavy emphasis on using uncertified teachers for unfilled positions. Unfortunately, this response has the potential for short and long-term impact on student and school outcomes. Teacher recruitment is a potential area of focus for stabilizing the supply of future educators. This systematic literature review was designed to identify strategies and factors associated with the recruitment of future special education teachers into the field. Identified factors include financial support, past experiences with individuals with disabilities, targeted recruitment, and flexible pathways. Implications for future researchers, teacher preparation programs, local school divisions, and policymakers are provided.
Sources of Civil and Sports Law as a sub-branch of Civil Law of Ukraine
Authors: Morhunov O. A. , Lysenko I. V. , Lysenko A. M. 
Published: August 2022

The article is devoted to the topical issues of analysis and systematization of sources of Sports and Civil Law. The role of sports in the development of modern society is constantly growing. The development of civil and sports legal relations requires the systematization of the sources of Sports Law, which should harmonize the entire complex of normative legal acts in the field of physical culture and sports. This would make it possible to develop educational programmes for training future specialists in this field, and would raise the legal resolution of disputes in this field to a more professional level.
State policy and private financing in this area require a qualitatively new level of legal regulation. This requires the creation and systematization of legal norms regulating sports relations. In particular, among the issues that require a legislative solution are the regulation of the legal status of the athlete, the peculiarities of the protection of the rights and interests of the subjects of sports relations, and more. For this, first of all, it is necessary to determine the legal sources of Civil and Sports Law and unify them with international legal sources.
Civil and Sports Law has its own sources of law. This is the basis for its inclusion in the structure of the civil legislation of Ukraine. Systematization of civil sports legislation should be carried out through codification. This is explained by the presence of a large number of sources of Sports Law, which contain conflict of laws rules and do not always meet international requirements and standards, as a rule, they are of a general nature. It will also help to eliminate the gaps and contradictions that currently exist in the legal acts regulating the relationship between physical culture and sports. In addition, Civil and Sports Law will meet international standards, the legal status of professional athletes and other subjects of sports legal relations will become more protected, research in the field of Private Law regulation of social relations arising in the field of physical culture and sports will be intensified, it will make it possible to establish the procedure for consideration of disputes between subjects of sports legal relations more transparent.
The female syndecan-4−/− heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels
Authors: Støle Thea Parsberg , Lunde Marianne , Shen Xin , Martinsen Marita , Lunde Per Kristian , Li Jia , Lockwood Francesca , Sjaastad Ivar , Louch William Edward , Aronsen Jan Magnus , Christensen Geir , Carlson Cathrine Rein 
Published: August 2022

Background: In cardiac muscle, the ubiquitously expressed proteoglycan syndecan-4 is involved in the hypertrophic response to pressure overload. Protein kinase Akt signaling, which is known to regulate hypertrophy, has been found to be reduced in the cardiac muscle of exercised male syndecan-4−/− mice. In contrast, we have recently found that pSer473-Akt signaling is elevated in the skeletal muscle (tibialis anterior, TA) of female syndecan-4−/− mice. To determine if the differences seen in Akt signaling are sex specific, we have presently investigated Akt signaling in the cardiac muscle of sedentary and exercised female syndecan-4−/− mice. To get deeper insight into the female syndecan-4−/− heart, alterations in cardiomyocyte size, a wide variety of different extracellular matrix components, well-known syndecan-4 binding partners and associated signaling pathways have also been investigated.Methods: Left ventricles (LVs) from sedentary and exercise trained female syndecan-4−/− and WT mice were analyzed by immunoblotting and real-time PCR. Cardiomyocyte size and phosphorylated Ser473-Akt were analyzed in isolated adult cardiomyocytes from female syndecan-4−/− and WT mice by confocal imaging. LV and skeletal muscle (TA) from sedentary male syndecan-4−/− and WT mice were immunoblotted with Akt antibodies for comparison. Glucose levels were measured by a glucometer, and fasting blood serum insulin and C-peptide levels were measured by ELISA.Results: Compared to female WT hearts, sedentary female syndecan-4−/− LV cardiomyocytes were smaller and hearts had higher levels of pSer473-Akt and its downstream target pSer9-GSK-3β. The pSer473-Akt inhibitory phosphatase PHLPP1/SCOP was lowered, which may be in response to the elevated serum insulin levels found in the female syndecan-4−/− mice. We also observed lowered levels of pThr308-Akt/Akt and GLUT4 in the female syndecan-4−/− heart and an increased LRP6 level after exercise. Otherwise, few alterations were found. The pThr308-Akt and pSer473-Akt levels were unaltered in the cardiac and skeletal muscles of sedentary male syndecan-4−/− mice.Conclusion: Our data indicate smaller cardiomyocytes, an elevated insulin/pSer473-Akt/pSer9-GSK-3β signaling pathway, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels in the female syndecan-4−/− heart. In contrast, cardiomyocyte size, and Akt signaling were unaltered in both cardiac and skeletal muscles from male syndecan-4−/− mice, suggesting important sex differences.
Detection of BaP in seawater based on multi-walled carbon nanotubes composites immunosenor
Authors: Yan Yirou , Qiu Chengjun , Qu Wei , Zhuang Yuan , Chen Kaixuan , Wang Cong , Zhang Ruoyu , Wang Ping , Wu Yuxuan , Gao Jiaqi 
Published: August 2022

Benzo(a)pyrene, as the main polycyclic aromatic hydrocarbon pollutant in marine oil spill pollution, has negative effects on marine ecology and human health. A facile and sensitive method of rapid benzo(a)pyrene detection in seawater is essential for marine conservation. In this paper, a novel immunosensor is fabricated using a multi-walled carbon nanotubes-chitosan composite loaded with benzo(a)pyrene antibody. This immunosensor is based on a biosensing assay mechanism that uses multi-walled carbon nanotubes-chitosan composites as conductive mediators to enhance electron transfer kinetics. Then, potassium ferricyanide was used as an electrochemical probe to produce an electrochemical signal for the voltammetric behavior investigation of the immune response by differential pulse voltammetry. Under optimal experimental conditions, the peak current change was inversely proportional to the benzo(a)pyrene concentration in the range of 0.5 ng⋅ml−1and 80 ng⋅ml−1with a detection limit of 0.27 ng⋅ml−1. The immunosensor was successfully applied to assay BaP in seawater, and the recovery was between 96.6 and 100%, which exhibited a novel, sensitive and interference-resistant analytical method for real-time water environment monitoring. The results demonstrate that the proposed immunosensor has a great potential for application in the monitoring of seawater.
Genomic transmission analysis of multidrug-resistant Gram-negative bacteria within a newborn unit of a Kenyan tertiary hospital: A four-month prospective colonization study
Authors: Villinger David , Schultze Tilman G. , Musyoki Victor M. , Inwani Irene , Aluvaala Jalemba , Okutoyi Lydia , Ziegler Anna-Henriette , Wieters Imke , Stephan Christoph , Museve Beatrice , Kempf Volkhard A. J. , Masika Moses 
Published: August 2022

ObjectiveMultidrug-resistant organisms (MDRO), especially carbapenem-resistant organisms (CRO), represent a threat for newborns. This study investigates the colonization prevalence of these pathogens in a newborn unit at a Kenyan tertiary hospital in an integrated approach combining routine microbiology, whole genome sequencing (WGS) and hospital surveillance data.MethodsThe study was performed in the Kenyatta National Hospital (KNH) in 2019 over a four-month period and included 300 mother-baby pairs. A total of 1,097 swabs from newborns (weekly), mothers (once) and the hospital environment were taken. Routine clinical microbiology methods were applied for surveillance. Of the 288 detected MDRO, 160 isolates were analyzed for antimicrobial resistance genes and phylogenetic relatedness using whole genome sequencing (WGS) and bioinformatic analysis.ResultsIn maternal vaginal swabs, MDRO detection rate was 15% (n=45/300), including 2% CRO (n=7/300). At admission, MDRO detection rate for neonates was 16% (n=48/300), including 3% CRO (n=8/300) with a threefold increase for MDRO (44%, n=97/218) and a fivefold increase for CRO (14%, n=29/218) until discharge. Among CRO, K. pneumoniae harboring blaNDM-1 (n=20) or blaNDM-5 (n=16) were most frequent. WGS analysis revealed 20 phylogenetically related transmission clusters (including five CRO clusters). In environmental samples, the MDRO detection rate was 11% (n=18/164), including 2% CRO (n=3/164).ConclusionOur study provides a snapshot of MDRO and CRO in a Kenyan NBU. Rather than a large outbreak scenario, data indicate several independent transmission events. The CRO rate among newborns attributed to the spread of NDM-type carbapenemases is worrisome.
Challenges and opportunities for implementing digital health interventions in Nepal: A rapid review
Authors: Parajuli Rojina , Bohara Dipak , KC Malati , Shanmuganathan Selvanaayagam , Mistry Sabuj Kanti , Yadav Uday Narayan 
Published: August 2022

BackgroundIn recent times, digital technologies in health care have been well recognized in Nepal. It is crucial to understand what is works well and areas that need improvements in the digital health ecosystem. This rapid review was carried out to provide an overview of Nepal's challenges and opportunities for implementing digital health interventions.MethodsThis study is reported according to PRISMA guidelines and used telehealth, telemedicine, e-health, mobile health, digital health, implementation, opportunities, challenges and Nepal as key search terms to identify primary studies published between 1 January 2010 and 30 December 2021 in four databases, namely PubMed, Google Scholar, Scopus, and CINAHL. Initially, identified studies were screened against predetermined selection criteria, and data were extracted, and the findings were narratively synthesized.ResultThe review identified various challenges, opportunities, and benefits of implementing digital health initiatives in Nepal. The most expressed challenge was inadequate technical facilities (lack of electricity and internet) and rugged geographical distribution, which makes transportation difficult in hilly and mountain areas. Shortage of skilled workforce and supportive policies were also notable challenges documented. Meanwhile, major opportunities identified were education and training of the students and health practitioners and increasing awareness among the general population.ConclusionThis review identified various factors associated with the successful implementation of digital health initiatives in Nepal. Our findings may guide the formulation of digital health policy and interventions to improve mass health outcomes using digital health services.
Preventive dental care is associated with improved healthcare outcomes and reduced costs for Medicaid members with diabetes
Authors: Lamster Ira B. , Malloy Kevin P. , DiMura Philip M. , Cheng Bin , Wagner Victoria L. , Matson Jacqueline M. , Proj Anisa , Xi Yizhao , Abel Stephen N. , Alfano Michael C. 
Published: August 2022

IntroductionPreventive dental services have been associated with improved health outcomes. This study expands on previous observations by examining the relationship between oral healthcare and healthcare outcomes and costs in a publicly insured population with diabetes.MethodsUtilization of dental services, healthcare outcomes and costs were evaluated for New York State Medicaid members with a diagnosis of diabetes mellitus (DM), ages 42 to 64, who were continuously enrolled between July 1, 2012 and June 30, 2015. Utilization of dental services focused on preventive dental care (PDC) and extractions and endodontic treatment (both indicative of advanced dental infection). Data were analyzed using regression models with propensity score weighting to control for potential confounding.ResultsReceipt of PDC was associated with lower utilization rates and costs compared to members who did not access dental services. The most pronounced average cost difference was observed for inpatient admissions at $823 per year for members who had at least one PDC without extraction or endodontic treatment. Each additional PDC visit received was associated with an 11% lower rate of inpatient admissions and lower average inpatient costs by $407 per member. The need for a dental extraction or endodontic therapy was associated with relatively higher rates and costs.ConclusionsThese findings demonstrate an association between PDC and improved healthcare outcome rates and lower average costs among members with DM and suggest a general health benefit associated with the provision of preventive dental care for persons with DM.