bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Movie recommender system based on topic modeling using machine learning methods
Authors: Kordabadi Mojtaba , Nazari Amin , Mansoorizadeh Muharram 
Published: July 2022

Abstract
In recent years, we have seen an increase in the production of films in a variety of categories and genres. Many of these products contain concepts that are inappropriate for children and adolescents. Hence, parents are concerned that their children may be exposed to these products. As a result, a smart recommendation system that provides appropriate movies based on the user’s age range could be a useful tool for parents. Existing movie recommender systems use quantitative factors and metadata that lead to less attention being paid to the content of the movies. This research is motivated by the need to extract movie features using information retrieval methods in order to provide effective suggestions. The goal of this study is to propose a movie recommender system based on topic modeling and text-based age ratings. The proposed method uses latent Dirichlet allocation (LDA) modelling to identify hidden associations between words, document topics, and the levels of expression of each topic in each document. Machine learning models are then used to recommend age-appropriate movies. It has been demonstrated that the proposed method can determine the user’s age and recommend movies based on the user’s age with 93% accuracy, which is highly satisfactory.
The conjunctival microbiome before and after azithromycin mass drug administration for trachoma control in a cohort of Tanzanian children
Authors: Pickering Harry , Ramadhani Athumani , Massae Patrick , Mafuru Elias , Malisa Aiweda , Mbuya Kelvin , Makupa William , Mtuy Tara , Derrick Tamsyn , Houghton Joanna , Bailey Robin , Mabey David , Burton Matthew , Holland Martin 
Published: July 2022

Abstract
Background
Trachoma, caused by ocular infection with Chlamydia trachomatis, is a neglected tropical disease that can lead to blinding pathology. Current trachoma control programmes have successfully used mass drug administration (MDA) with azithromycin to clear C. trachomatis infection and reduce transmission, alongside promoting facial cleanliness for better personal hygiene and environmental improvement. In areas of low-trachoma endemicity, the relationship between C. trachomatis infection and trachomatous disease weakens, and non-chlamydial bacteria have been associated with disease signs.
Methods
We enrolled a cohort of children aged 6–10 years from three adjacent trachoma endemic villages in Kilimanjaro and Arusha regions, Northern Tanzania. Children were divided into four clinical groups based on the presence or absence of ocular C. trachomatis infection and clinical signs of trachomatous papillary inflammation (TP). To determine the impact of treatment on the ocular microbiome in these clinical groups, we performed V4-16S rRNA sequencing of conjunctival DNA from children 3–9 months pre-MDA (n = 269) and 3-months post-MDA (n = 79).
Results
C. trachomatis PCR-negative, no TP children had the highest pre-MDA ocular microbiome alpha diversity, which was reduced in C. trachomatis infected children and further decreased in those with TP. Pre-MDA, Haemophilus and Staphylococcus were associated with C. trachomatis infection with and without concurrent TP, while Helicobacter was increased in those with TP in the absence of current C. trachomatis infection. Post-MDA, none of the studied children had ocular C. trachomatis infection or TP. MDA increased ocular microbiome diversity in all clinical groups, the change was of greater magnitude in children with pre-MDA TP. MDA effectively reduced the prevalence of disease causing pathogenic non-chlamydial bacteria, and promoted restoration of a normal, healthy conjunctival microbiome.
Conclusions
We identified Helicobacter as a non-chlamydial bacterium associated with the clinical signs of TP. Further investigation to determine its relevance in other low-endemicity communities is required. MDA was shown to be effective at clearing C. trachomatis infection and other non-chlamydial ocular pathogens, without any detrimental longitudinal effects on the ocular microbiome. These findings suggest that azithromycin MDA may be valuable in trachoma control even in populations where the relationship between clinical signs of trachoma and the prevalence of current ocular C. trachomatis infection has become dissociated.
Isoflavone consumption reduces inflammation through modulation of phenylalanine and lipid metabolism
Authors: Shrode Rachel L. , Cady Nicole , Jensen Samantha N. , Borcherding Nicholas , Mangalam Ashutosh K. 
Published: July 2022

Abstract
IntroductionPhytoestrogen found in soy, fruits, peanuts, and other legumes, has been identified as a metabolite capable of providing beneficial effect in multiple pathological conditions due to its ability to mimic endogenous estrogen. Interestingly, the health promoting effect of phytoestrogens such as isoflavone is dependent on the presence of gut bacteria with ability to metabolize dietary phytoestrogen into metabolite such as equol which have higher affinity for endogenous estrogen receptors. We have previously shown that patients with multiple sclerosis (MS), a neuroinflammatory disease lack gut bacteria with the ability to metabolize phytoestrogen. We have validated the importance of phytoestrogen and gut bacteria in disease protection utilizing an animal model of MS. Specifically, we have shown that an isoflavone rich diet can protect from neuroinflammatory diseases and that protection was dependent on the ability of gut bacteria to metabolize isoflavone into equol. Additionally, mice on a diet with isoflavone showed an anti-inflammatory response compared to the mice on a phyto-free diet. However, it is unknown how isoflavone and/or equol mediates its protective effect especially the effect of isoflavone on host metabolomics. ObjectivesIn this study we utilized untargeted metabolomics to identify the metabolites modulated by the presence of dietary isoflavone. ResultsWe found that the consumption of isoflavone increases anti-inflammatory monounsaturated fatty acids and beneficial polyunsaturated fatty acids while reducing pro-inflammatory glycerophospholipids, sphingolipids, phenylalanine metabolism, and arachidonic acid derivatives. ConclusionIsoflavone consumption alters the systemic metabolic landscape through resultant increase in monounsaturated fatty acids and beneficial polyunsaturated fatty acids while reducing proinflammatory metabolites and pathways. This highlights a potential mechanism by which an isoflavone diet modulate immune mediated disease.
Accessing Trends, and Measuring Sexual and Location Disparities of the Performance of National Examination Examinees: The case of Amhara Regional State Grade Ten Students
Authors: Alemu Kidanie Aragaw , Mohammed Mohammed Oumer 
Published: July 2022

Abstract
Background
Examinations are given to certify and select candidates for higher educations. The Ethiopian General Secondary Education Certificate Examination (EGSECE) was administered from 2001 to 2019. This study was done on grade ten students’ results who were taken the EGSECE exams in Amhara region 2001 to 2017. The purpose of this research was to see the trends of absolute and relative measures of the national exam sitters and passers, and evaluate sexual and locational disparities of their performances.
Method
The researchers would use retrospective research design and adopted multi stage cluster random sampling. Students were the primary units while Zones where their schools found were secondary. All grade ten students registered to take the EGSECE exam in each year in several high schools found in different administrative zones of the region were our sample. To analyze the data, the researchers used trend and variance analysis.
Results
Though the numbers of EGSECE exams sitters in the region were increased year to year, the relative numbers of passers were very low. The researchers found the gap between the trends of the numbers of students registered and took the national examinations were narrow. As time increased, the area between the trends of the numbers of students took the national exam and those got pass mark became wider. The trends of the promotion rates were the mirror images of the repetition rates. As time goes, the areal gap between the trends of the promotion rates of males and females became narrow. The mean promotion rate differences between male and female students were significant. Also, the average promotion rate differences of students among their administrative zones were significant.
Conclusion
In Amhara region little information exists on trend analysis of national exam results of students, and comparison of their mean promotion rates segregated by gender and zone. This research will enable the regional and zonal education bureau and woreda education offices to predict the future movement of its student’s national exam performances, measure gender and location disparity, and perceive quality and internal efficiency of the education system in the region, zone and woreda.
Prioritizing management options using a risk assessment for soil erosion based on GIS, remote sensing, and RUSLE. A case study of Midhagdu Watershed, Eastern Ethiopia.
Authors: Mohammed Sultan , Gemechu Gadisa Fayera , Aliyi Michael , Gemechu Tewekel Melese 
Published: July 2022

Abstract
This study prioritises management options and assesses the risk of soil erosion in the Midhagdu Watershed in eastern Ethiopia. The themed map was developed using satellite data including SRTM-DEM, Landsat OLI, rainfall data, and soil data. The RUSLE model as well as GIS and remote sensing methods were used in the experiment. The experiments revealed that the factors that affect soil erosion risk such as rainfall erosivity (R), soil erodibility (K), slope length and steepness (LS), cover management (C), and anthropogenic soil erosion control practises factor values were distributed spatially and ranged in values from 41.365 to 43.793MJ mm ha-1yr-1, 0.26 to 0.31t ha-1MJ-1mm-1, 0 to 220.512, 0.21 to 0.87, and 0.11 to 1, respectively, and the most powerful factor that influences soil erosion risk was topography(LS) with a value of 0.885.
The results of the grid cell-based RUSLE model showed that 52.24 percent of the Midhagdu watershed (28.37 km2 out of 54.3 km2) had low to moderate soil erosion levels and that 47.76 percent (25.94 km2 out of 54.3 km2) had high to extremely high soil erosion risk levels. By taking into account regions and priority classes based on soil erosion risk levels, the conclusions of this article suggest an early intervention to better plan soil erosion risk management.
Awareness And Knowledge of Moonlighting in the Public Service: A Case of Ghana Scholarship Secretariat
Authors: Acheampong Joseph Ofori 
Published: July 2022

Abstract
The paper aims to explore the awareness/knowledge, motives, and implications of moonlighting behavior in the Ghana Scholarship Secretariat. A qualitative approach was the primary source of data collection. Data collection was conducted through an in-depth semi-structured interview with key informants who were purposively selected. Field data were transcribed into a written report and analyzed thematically. It emerged from the study public servants are aware and have knowledge of the phenomenon of moonlighting. The study found that income supplement and retirement planning are the main reason why the majority of public servants engage in moonlighting, although few highlighted the negative implication of the practice. The moonlighting policy at the public service was weak and leniently enforced. Moonlighting behavior affects the performance and delivery of public service. The study conclusion is that moonlighting is pervasive at the Ghana Scholarship Secretariat. The interviewees recommended that the Public Service Commission should enact policy actions to regulate moonlighting practices.
Role of lung ultrasound in the assessment of hydration status of chronic haemodialysis patients
Authors: Dongmo Sylviane Fomekong , Moulion Jean-Roger Tapouh , Teuwafeu Denis Georges , Chuangueu Samory Guedje , Folefack François Jérôme Kaze , Moifo Boniface 
Published: July 2022

Abstract
Background
Fluid overload is frequent in haemodialysis (HD) and is one of the major factors of cardiovascular morbidity and mortality for chronic haemodialysis patients. The main challenge with chronic haemodialysis patients is indeed the maintenance of a normal extracellular volume through dry weight determination. Our study aimed at assessing the role of lung ultrasound in the detection of B-lines for the determination of hydration status in chronic haemodialysed patients.
Methods
We conducted a cross sectional study including 31 patients undergoing chronic HD treatment for at least 3 months, in Yaounde University Teaching Hospital dialysis unit. Lung ultrasonography and clinical examinations were performed immediately before dialysis, and 30 minutes after dialysis. Differences between variables before and after dialysis were measured to assess dialysis’s effect. Association between categorical variables was assessed with Chi-squared test or Fischer test, and Rho’s Spearman coefficient for quantitative variables.
Results
There were reduction in median of B-lines score after dialysis [12(7–26) versus 8(5–13)], clinical score [2(1–3) versus 0((-1)-2)], mean of systolic blood pressure (164.74 ± 26.50 versus 158.48 ± 27.89), frequency of dyspnoea in patients (32.3% versus 6.5%); and raising frequency of cramps in patients (0% versus 19.4%), all statistically significant (p ≤ 0.031). B-lines score before and after dialysis was associated with dyspnoea and raised jugular venous pressure (p < 0.05). B-lines score before dialysis was correlated with B-lines score after dialysis (r = 0.805; p < 0.001), B-lines reduction (r = 0.862; p < 0.001) and clinical score (r = 0.49; p = 0.005). Reduction of B-lines score was not correlated with weight loss.
Conclusion
Lung ultrasound for detection of B-lines reflects variation of extracellular volume during dialysis and can even capture pulmonary oedema at pre-clinical stage. It is then a reliable and sensible method in assessing hydration status. It could constitute a better alternative in objective and accurate definition of dry weight, specifically in the African and Cameroonian context, with its assets at low cost, its availability, its easiness to perform in large population of haemodialysis patients.
Dynamics of unemployment and economic growth on terrorism in Nigeria - Evidence from a linear quantile modelling approach
Authors: Saidu Mohammad Tukur 
Published: July 2022

Abstract
The study is aim to developed a model that examines the effect of unemployment and economic growth on terrorism activities in Nigeria by adopting immiserizing modernization theory with a simulation using a linear quantile modelling approach. The study covers a period between 1990 to 2020 using annual data. The result from the study shows that, increase in unemployment leads to higher level of terrorism activity in the country especially Boko Haram activities having a higher impact. It is also found that, lower economic growth contribute to higher terrorism, as a result of the poor performance in various sector of the economy especially government expenditure on security will then became too low. The result point to an urgent need to control the level of unemployment by injecting more in the economy to promote various sectors which will definitely increase job opportunities and provision of an enabling environment for the working population to engage themselves in a more efficient sector of the economy capable in absorbing larger percentage of our youth, especially agro-allied industry which will further improve the economic performance.JEL classification; E24, J64, O40
A System Dynamics Model of Sustainable Construction for High rise Residential Projects in Developing Countries: Case of Indonesia
Authors: Sutantio Aditya , Anwar Nadjadji , Wiguna I Putu Artama , Suryani Erma 
Published: July 2022

Introduction:
Despite its contribution to urban development, high rise residential projects also cause adverse impact on the living environment. To address the problem, a sustainable construction as a new paradigm has been introduced. Various papers have examined the importance of sustainable construction. However, most studies focused on social and environmental aspects and with few consideration on the economic objective of the business. This study aimed to fill the research gap by presenting a dynamic model to improve social, environmental and economic performance of sustainable construction for high rise residential projects in developing countries.

Methods:
This study started with a literature review as a basis for a qualitative survey conducted in thirty high rise residential projects in Indonesia, to identify the influencing factors and the interrelationships. To analysis the data, a system dynamics approach was utilized.

Results:
The simulations reveal that the current regulation and construction practices are insufficient to reduce environmental negative impacts. In order to formulate better policies, three scenarios comprised the implementation of building energy regulation, tax incentives policy, and a policy mix were employed. The results show that the scenarios could improve construction sustainability performance in some extends.

Conclusion:
The combination of building regulation and tax incentives policy is effective to achieve environmental and social as well as economic aspects of sustainable construction which is suitable for investors. Based on the results, it is concluded that the model can be used to formulate various policies in the future to enhance sustainable construction of high rise residential projects in developing countries.
Efficacy of Anterior Tooth Simulations with Clear Aligner Therapy - A Retrospective Cohort study of Invisalign and Flash Aligner Systems
Authors: Sorour Hanadi , Fadia Dhaval , Ferguson Donald J. , Makki Laith , Adel Samar , Hansa Ismaeel , Vaid Nikhilesh R. 
Published: July 2022

Purpose:
The purpose of this study was to compare the efficacy of tooth movement between two clear aligner systems by comparing the predicted treatment outcomes versus actual outcomes achieved using a 3D best-fit algorithm.

Materials & Methods:
Clear aligner therapy (CAT) was used to treat 62 patients; n=38 Invisalign® and n=24 Flash®. The Invisalign group had a male to female distribution of 13:25 and a mean age of 35.5, while the Flash group had a male to female distribution of 6:18, with a mean age of 29.2. Differences in predicted versus achieved actual outcomes were compared using eModel Compare 8.1 software.

Results:
1) Intra-group differences between predicted and achieved tooth movements for angular movements were statistically (P<0.05) and clinically (>2°) significant with both treatment methods, except for tipping of maxillary and mandibular incisors for Flash® (<2◦). 2) Inter-group results demonstrated statistically significant differences in favor of Flash® for maxillary central incisor Tip (1.3°), BL movements for maxillary canines (0.1mm), and mandibular central incisor Rotations (1°). These did not exceed the threshold for the clinical relevance of 2° or 0.5mm.

Conclusions:
There were no differences in clinical accuracy and efficacy between Invisalign or Flash aligner systems in achieving predicted tooth movement.
Effect of 0.2% Chitosan Associated with Different Final Irrigant Protocols on the Fiber Post Bond Strength to Root Canal Dentin of Bovine Teeth: An In-vitro Study
Authors: Dorileo Maura Cristiane Gonçales Orçati , Guiraldo Ricardo Danil , Lopes Murilo Baena , de Almeida Decurcio Daniel , Guedes Orlando Aguirre , Aranha Andreza Maria Fábio , Borges Álvaro Henrique , Júnior Alcides Gonini 
Published: July 2022

Objective:
This in-vitro study investigated the effect of 0.2% Chitosan associated with different final irrigant protocols on the bond strength of fiber posts (FP) to root canal dentin.

Methods:
Fifty bovine incisors roots were prepared using the ProTaper Universal system, irrigated with 2.5% sodium hypochlorite, and divided into one control group (n=10) with no final irrigant protocol and four experimental groups (n=10), which were defined according to the combination of chelating solution (17% EDTA and 0.2% Chitosan) and irrigant activation/delivery method [conventional irrigation (CI), and passive ultrasonic irrigation (PUI)]. Post spaces were prepared to a depth of 12 mm using #1-5 Largo drills, and the FP were cemented using self-adhesive resin cement. Two slices of 2 mm in thickness from each third were obtained and submitted to the micropush-out test. After testing the push-out strength, the slices were analyzed under a stereomicroscope at 40× magnification for bond failure patterns determination. Statistical analysis was performed using three-way ANOVA followed by Tukey’s test (α = 0.05).

Results:
The control and 17% EDTA + CI groups exhibited significantly lower bond strength than 0.2% Chitosan + CI, 17% EDTA + PUI, and 0.2% Chitosan + PUI groups in the cervical third (P = 0.00). The cervical third had higher values than the middle and apical thirds in control (P = 0.00), 17% EDTA + PUI (P = 0.00), and 0.2% Chitosan + PUI groups (P = 0.00). Adhesive cement-dentin failure type was predominant in all groups.

Conclusion:
The use of 0.2% chitosan did not affect the bond strength of FP to root dentin. Passive ultrasonic activation of chelating solutions resulted in an improvement in bonding strength.
Molecular Variants in Genes related to the Response to Ocular Hypotensive Drugs in an Afro-Colombian Population
Authors: Silva-Alarcon Santiago , Valencia Claudia , Newball Lyle , Saldarriaga Wilmar , Castillo Andres 
Published: July 2022

Aims:This study aimed to conduct an exploratory analysis of the pharmacogenomic variants involved in ocular hypotensive drugs to understand the individual differential response in an Afro-descendant population.Background:Glaucoma is the leading cause of irreversible blindness worldwide. The pharmacologic treatment available consists of lowering intraocular pressure by administering topical drugs. In Asian and Caucasian people, pharmacogenomic variants associated with the efficacy of these treatments have been identified. However, in Afro-descendant populations, there is a profound gap in this knowledge.Objective:This study identified the pharmacogenomic variants related to ocular hypotensive efficacy treatment in Afro-descendant individuals from the Archipelago of San Andres and Providence, Colombia.Methods:An analysis of whole-exome sequencings (WES), functional annotation, and clinical significance was performed for pharmacogenomic variants reported in PharmGKB databases; in turn, an in silico available prediction analysis was carried out for the novel variants.Results:We identified six out of 18 non-synonymous variants with a clinical annotation in PharmGKB. Five were classified as level three evidence for the hypotensive drugs; rs1801252 and rs1801253 in the ADRB1 gene and rs1042714 in the ADRB2 gene. These pharmacogenomic variants have been involved in a lack of efficacy of topical beta-blockers and higher systolic and diastolic pressure under treatment with ophthalmic timolol drug. The rs1045642 in the ABCB1 gene was associated with greater efficacy of treatments with latanoprost drug. Also, we found the haplotypes *17 for CYP2D6 and *10 for CYP2C19; both related to reducing the enzyme activity to timolol drug metabolization. In addition, we observed 50 novel potentially actionable variants; 36 synonymous, two insertion variants that caused frameshift mutations, and 12 non-synonymous, where five were predicted to be pathogenic based on several pathogenicity predictions.Conclusion:Our results suggested that the pharmacogenomic variants were found to decrease the ocular hypotensive efficacy treatment in a Colombian Afro-descendant population and revealed a significant proportion of novel variants with a potential to influence drug response.