bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring veterinary professionals’ perceptions of pet weight‐related communication in companion animal veterinary practice
Authors: Sutherland Katja A. , Coe Jason B. , O'Sullivan Terri L. 
Published: August 2022

AbstractBackgroundPet obesity is commonly encountered by veterinary professionals, yet little is known about their perception of communicating about pet weight. The objective of this study was to explore veterinary professionals’ perception of discussing pet obesity with clients.MethodsAn online survey targeting veterinary professionals was distributed via social media and veterinary organisation newsletters. Topics included respondents’ perceptions of weight‐related communication, factors related to approaching weight conversations and implicit weight bias.ResultsA total of 102 respondents to the survey were included in the final analysis. Avoidance of discussing pet obesity with certain clients was common (53.9%; 55/102). The most endorsed term for describing pets with excess weight to clients was ‘overweight’ (97.1%; 99/102). The pet's body condition score was rated the most important factor to consider when deciding how to approach a weight discussion with clients. Although only 29 participants completed the implicit association test (IAT), most of these participants were identified as having an unconscious preference for thin people. The small sample size limited the vignette analysis to descriptive only, and the IAT results should be interpreted cautiously.ConclusionThis exploratory, cross‐sectional study provides early insight into veterinary professionals’ perceptions of pet obesity‐related communication and suggests the presence of weight bias in the profession that warrants further investigation.
Assessment of an actuator disk‐based approach for the prediction of fatigue loads in a perspective of wind farm‐scale application
Authors: Moens Maud , Duponcheel Matthieu , Chatelain Philippe 
Published: August 2022

AbstractThis work aims at assessing the loads and the fatigue estimates computed using an advanced actuator disk (AD) method coupled to large eddy simulation, at a resolution appropriate for large wind farm calculations. In order to compute pertinent fatigue loads, blade trajectories are replicated through the disk, and the AD aerodynamic forces are interpolated onto these “virtual blades” at each time step. This approach, denoted AD‐B, is verified against a Vortex‐Particle Mesh (VPM) method coupled to immersed lifting lines at a fine resolution, through simulations of an isolated rotor in a turbulent wind. Two different methods are used to evaluate the fatigue damages: the widely used Rainflow counting (RFC) procedure and the spectral Dirlik's approach (DK), both combined with a Palgrem–Miner rule. In the present work, the DK counting method is considered to further investigate the potential of extrapolating some loading data in the high frequencies, uncaptured by the AD‐B model at a coarse resolution. The results show that the fatigue estimates computed using the RFC procedure are very similar for the VPM and the AD‐B methods, thus without any modeling of the unresolved scales for the disk. Indeed, the AD‐B model captures the loads of middle and large amplitudes that contribute the most to the rotor damage. The use of extrapolated loading data makes the AD‐B fatigue estimates closer to the VPM ones, but the DK counting method globally leads to results that are quite different from those obtained using the RFC procedure. Further investigations are thus required for the combination of extrapolated loading information and spectral counting methods.
Tensor Products of Dendroidal Sets
Authors: Heuts Gijs , Moerdijk Ieke 
Published: August 2022

AbstractIn the first chapter we described the Boardman–Vogt tensor product of two operads. This operadic tensor product induces a related tensor product on dendroidal sets by the method of Kan extension. This new dendroidal tensor product agrees with the Cartesian product when restricted to simplicial sets, and reproduces the Boardman– Vogt tensor product when dendroidal sets are realized as operads by the functor τ.
Refined topological vertex with ON-planes
Authors: Kim Sung-Soo , Wei Xing-Yue 
Published: August 2022

Abstract
We propose refined topological vertex formalism for 5-brane systems with ON-planes by introducing a new vertex associated with reflection over an ON-plane, which gives rise to new vertex and edge factors. We test our proposal against various 5d 𝒩 = 1 gauge theories which can be realized as 5-brane webs with ON-planes, which include D-type quiver theories. In particular, we compute the refined partition functions for 6d E-string theory on a circle as well as 5d SU(3) theory at the Chern-Simons level 9, which can be realized as 5-brane webs with two ON-planes. Our results completely agree with the known results.
Dilaton and massive hadrons in a conformal phase
Authors: Del Debbio Luigi , Zwicky Roman 
Published: August 2022

AbstractAs the number of fermion fields is increased, gauge theories are expected to undergo a transition from a QCD-like phase, characterised by confinement and chiral symmetry breaking, to a conformal phase, where the theory becomes scale-invariant at large distances. In this paper, we discuss some properties of a third phase, where spontaneously broken conformal symmetry is characterised by its Goldstone boson, the dilaton. In this phase, which we refer to as conformal dilaton phase, the massless pole corresponding to the Goldstone boson guarantees that the conformal Ward identities are satisfied in the infrared despite the other hadrons carrying mass. In particular, using renormalisation group arguments in Euclidean space, we show that for massless quarks the trace of the energy momentum tensor vanishes on all physical states as a result of the fixed point. This implies the vanishing of the gluon condensate and suggests that the scale breaking is driven by the quark condensate which has implications for the cosmological constant. In addition form factors obey an exact constraint for every hadron and are thus suitable probes to identify this phase in the context of lattice Monte Carlo studies. For this purpose we examine how the system behaves under explicit symmetry breaking, via quark-mass and finite-volume deformations. The dilaton mass shows hyperscaling under mass deformation, viz.$$ {m}_D=\mathcal{O}\left({m}_q^{1/\left(1+{\gamma}^{\ast}\right)}\right) $$mD=Omq1/1+γ∗. This provides another clean search pattern.
dE/dx from boosted long-lived particles
Authors: Giudice Gian F. , McCullough Matthew , Teresi Daniele 
Published: August 2022

Abstract
At colliders massive long-lived charged particles could be revealed through their anomalously large ionisation energy loss dE/dx. In this paper we explore a class of scenarios in which the LLPs are particularly boosted, owing to production from the decay of a heavy parent resonance. Such scenarios give rise to unique signatures as compared to traditionally considered dE/dx new-physics benchmarks. We demonstrate that this class of models, unlike traditional new-physics theories, can explain the recently reported excess of events in the dE/dx search by the ATLAS collaboration without conflicting with the determination of β from ionisation and time-of-flight measurements.
The dark side of the proton
Authors: McCullough Matthew , Moore James , Ubiali Maria 
Published: August 2022

Abstract
We study the sensitivity of the High-Luminosity LHC to a light baryonic dark photon B, primarily coupled to quarks, as a constituent of the proton. This is achieved by allowing for a dark photon parton distribution function (PDF) in the PDF evolution equations. Depending on the mass and coupling of the dark photon, the evolution of standard quark and gluon PDFs is distorted to varying degrees. By analysing the effect of the dark photon on the tails of Drell-Yan invariant mass distributions, we demonstrate the potential of the LHC in determining competitive bounds on dark photon parameter space.
Balancing NAD+ deficits with nicotinamide riboside: therapeutic possibilities and limitations
Authors: Cercillieux Angelique , Ciarlo Eleonora , Canto Carles 
Published: August 2022

AbstractAlterations in cellular nicotinamide adenine dinucleotide (NAD+) levels have been observed in multiple lifestyle and age-related medical conditions. This has led to the hypothesis that dietary supplementation with NAD+ precursors, or vitamin B3s, could exert health benefits. Among the different molecules that can act as NAD+ precursors, Nicotinamide Riboside (NR) has gained most attention due to its success in alleviating and treating disease conditions at the pre-clinical level. However, the clinical outcomes for NR supplementation strategies have not yet met the expectations generated in mouse models. In this review we aim to provide a comprehensive view on NAD+ biology, what causes NAD+ deficits and the journey of NR from its discovery to its clinical development. We also discuss what are the current limitations in NR-based therapies and potential ways to overcome them. Overall, this review will not only provide tools to understand NAD+ biology and assess its changes in disease situations, but also to decide which NAD+ precursor could have the best therapeutic potential.
Concentration of Eigenfunctions of Schrödinger Operators
Authors: Mityagin Boris , Siegl Petr , Viola Joe 
Published: August 2022

AbstractWe consider the limit measures induced by the rescaled eigenfunctions of Schrödinger operators with even confining potentials. We show that the limit measure is supported on $$[-1,1]$$

[
-
1
,
1
]

and with the density proportional to $$(1-|x|^\beta )^{-1/2}$$

(
1
-
|
x
|

β

)

-
1
/
2

when the non-perturbed potential resembles $$|x|^\beta $$

|
x
|

β

, $$\beta >0$$

β
>
0

, for large x, and with the uniform density for super-polynomially growing potentials. We compare these results to analogous results in orthogonal polynomials and semiclassical defect measures.
Toleranz und Akzeptanz der intratympanalen Injektion
Authors: Mühlmeier Guido , Tisch Matthias 
Published: August 2022

Zusammenfassung
Hintergrund
Die intratympanale Gabe von Steroiden ist Bestandteil der Therapie von akuten Hörverlusten. Bislang existieren nur wenig Daten zur Akzeptanz und Toleranz aus Sicht der Patient*innen.

Material und Methoden
Zu den gesundheitlichen Voraussetzungen und den Umstäden ihrer intratympanalen Therapie wurden 84 Patient*innen befragt.

Ergebnisse
Es stellten sich 38 Frauen und 46 Männer im Alter von durchschnittlich 57,2 Jahren meist auf Empfehlung ihres HNO-Arztes zur Zweitlinientherapie vor und empfanden die Injektionen zu 3,6 % als schmerzhaft, 22,6 % unangenehm, 67,9 % erträglich und zu 41,7 % als schmerzfrei (Mehrfachnennungen möglich). Eine Weiterempfehlung gaben 77,4 %, eine fehlende Empfehlung resultierte aus mangelnder Wirkung und unangenehmer Empfindung.

Schlussfolgerung
Der weit überwiegende Anteil der Behandelten beurteilt die intratympanale Therapie als erträglich und gibt eine Weiterempfehlung. Die enge Patientenführung ist ein entscheidender Therapiebaustein.
Uremic mouse model to study vascular calcification and “inflamm-aging”
Authors: Tölle Markus , Henkel Cornelia , Herrmann Jaqueline , Daniel Christoph , Babic Milen , Xia Mengdi , Schulz Anna M. , Amann Kerstin , van der Giet Markus , Schuchardt Mirjam 
Published: August 2022

AbstractCalcification and chronic inflammation of the vascular wall is a high-risk factor for cardiovascular mortality, especially in patients with chronic uremia. For the reduction or prevention of rapid disease progression, no specific treatment options are currently available. This study aimed to evaluate an adenine-based uremic mouse model for studying medial vessel calcification and senescence-associated secretory phenotype (SASP) changes of aortic tissue to unravel molecular pathogenesis and provide a model for therapy testing. The dietary adenine administration induced a stable and similar degree of chronic uremia in DBA2/N mice with an increase of uremia blood markers such as blood urea nitrogen, calcium, creatinine, alkaline phosphatase, and parathyroid hormone. Also, renal fibrosis and crystal deposits were detected upon adenine feeding. The uremic condition is related to a moderate to severe medial vessel calcification and subsequent elastin disorganization. In addition, expression of osteogenic markers as Bmp-2 and its transcription factor Sox-9 as well as p21 as senescence marker were increased in uremic mice compared to controls. Pro-inflammatory uremic proteins such as serum amyloid A, interleukin (Il)-1β, and Il-6 increased. This novel model of chronic uremia provides a simple method for investigation of signaling pathways in vascular inflammation and calcification and therefore offers an experimental basis for the development of potential therapeutic intervention studies.
Graphical abstract
Improving survival in metastatic renal cell carcinoma (mRCC) patients: do elderly patients benefit from expanded targeted therapeutic options?
Authors: Eggers Hendrik , Schünemann Christoph , Grünwald Viktor , Rudolph Linda , Tiemann Maria-Luisa , Reuter Christoph , Anders-Meyn Merle Freya , Ganser Arnold , Ivanyi Philipp 
Published: August 2022

Abstract
Introduction
Treatment advances in metastatic renal cell carcinoma (mRCC) have improved overall survival (OS) in mRCC patients over the last two decades. This single center retrospective analysis assesses if the purported survival benefits are also applicable in elderly mRCC patients.

Methods
401 patients with mRCC treated at Hannover Medical School from 01/2003–05/2016 were identified and evaluated by chart review. Treatment periods were defined as 01.01.2003–31.12.2009 (P1) and 01.01.2010–31.05.2016 (P2). Age groups were defined according to WHO classes (≤ 60 years: younger, > 60–75 years: elderly and > 75 years: old). Descriptive statistics, Kaplan–Meier analysis and logistic regression were performed.

Results
Median OS improved from 35.1 months in P1 to 59.1 months in P2. Sub-division into the respective age groups revealed median survival of 38.1 (95%-CI: 28.6–47.6) months in younger patients, 42.9 (95%-CI: 29.5–56.3) months among elderly patients and 27.3 (95%-CI: 12.8–41.8) months among old patients. Risk reduction for death between periods was most evident among old patients (young: HR 0.71 (95%-CI: 0.45–1.13, p = 0.2); elderly: HR 0.62 (95%-CI: 0.40–0.97, p = 0.04); old: HR 0.43 (95%-CI: 0.18–1.05, p = 0.06)). Age ≥ 75 years was an independent risk factor for death in P1 but not in P2.

Conclusion
Improved OS in the targeted treatment period was confirmed. Surprisingly elderly and old patients seem to profit the most form expansion of therapeutic armamentarium, within the TKI-dominated observation period.
Surgical management in immunosuppressed patients with sigmoid diverticulitis, still a challenge: a single-center observational study
Authors: Vaghiri Sascha , Prassas Dimitrios , Knoefel Wolfram Trudo , Krieg Andreas 
Published: August 2022

Abstract
Purpose
The question of whether immunosuppressed (IS) patients should be offered elective sigmoidectomy following a single episode of diverticulitis is controversial. We intended to examine the perioperative outcome of IS and immunocompetent (IC) patients after sigmoid resection.

Methods
A single institutional cohort study was conducted, including all surgically treated patients with sigmoid diverticulitis between 2004 and 2021. IS and IC patients were further subdivided into emergency and elective cases. Morbidity and mortality in both groups and factors influencing surgical outcome were examined using uni- and multivariate regression analyses.

Results
A total of 281 patients were included in the final analysis. Emergency surgery was performed on 98 patients while 183 patients underwent elective sigmoid resection. Emergency sigmoidectomy demonstrates significantly higher morbidity and mortality rates in IS patients as compared to IC patients (81.81% vs. 42.1%; p = 0.001, respectively 27.27% vs. 3.94%; p = 0.004), while major morbidity and mortality was similar in both groups in the elective setting (IS: 23.52% vs. IC: 13.85%; p = 0.488, respectively IS: 5.88% vs. IC: 0%; p = 1). On multivariate regression analysis for major postoperative morbidity, ASA score [OR 1.837; (95% CI 1.166–2.894); p = 0.009] and emergency surgery under immunosuppression [OR 3.065; (95% CI 1.128–8.326); p = 0.028] were significant. In-hospital mortality was significantly related to age [OR 1.139; (95% CI 1.012–1.282); p = 0.031], preoperative CRP count [OR 1.137; (95% CI 1.028–1.259); p = 0.013], and immunosuppression [OR 35.246; (95% CI 1.923–646.176), p = 0.016] on multivariate analysis.

Conclusions
Elective surgery for sigmoid diverticulitis in immunocompromised patients demonstrates higher efficacy and safety when compared to sigmoid resection in the emergency setting.
Newly detected shock-induced high-pressure phases formed in amphibolite clasts of the suevite breccia (Ries impact crater, Germany): Liebermannite, kokchetavite, and other ultrahigh-pressure phases
Authors: Stähle Volker , Chanmuang N. Chutimun , Schwarz Winfried H. , Trieloff Mario , Varychev Alexander 
Published: August 2022

AbstractAmphibolite clasts in the suevite of the Ries impact crater contain shock-induced melt veins (SMVs) with high-pressure phases such as majoritic garnet, jadeitic clinopyroxene and others. In addition, heat conduction from hot SMVs into adjacent rock portions locally produced further high P–T melt pools. These melts were preferentially generated in rock domains, where the SMVs cross older (‘pre-Ries’) veinlets with analcime or prehnite and larger grains of sericitized plagioclase. Melting of such chemically different local bulk systems (Na-, Ca-, Ca-Na- and K-Na-rich) was facilitated by low solidus temperatures of the original secondary OH-bearing phases. From the resulting shock-induced melts, liebermannite, kokchetavite, jadeite, nonstoichiometric and albitic jadeite, grossular, vuagnatite, lawsonite + coesite, and clinozoisite crystallized during pressure release. Vuagnatite is now proven to be a genuine high-pressure phase. Its ubiquitous distance of 20–35 μm from the hot shock veins suggests a temperature sensitivity typical for an OH-bearing phase. In local Na-rich melts albitic jadeite appears instead of the assemblage jadeite + SiO2. Liebermannite, a dense polymorph of K-feldspar was identified by Raman spectroscopy. After stishovite, liebermannite constitutes the second known high-pressure phase in the Ries that contains silicon exclusively in six-fold coordination. The KAlSi3O8-polymorph kokchetavite was formed in alkali-rich melt glasses. Pressure and temperature values in the range of about 8–11 GPa and ~ 800–1100 °C were estimated from the chemical compositions of locally occurring majoritic garnets (Si = 3.21–3.32 and 3.06–3.10 apfu), respectively, and the presence of fine-grained aggregates of lawsonite and coesite. Generally, the neighboring areas of the veins are characterized by a sequence of variable high-pressure phases documenting strongly falling P–T conditions with increasing distance from the vein. These novel features enlighten the dynamic event during passage of a shock wave.
Fractional Hardy equations with critical and supercritical exponents
Authors: Bhakta Mousomi , Ganguly Debdip , Montoro Luigi 
Published: August 2022

AbstractWe study the existence, nonexistence and qualitative properties of the solutions to the problem $$\begin{aligned} ({\mathcal {P}}) \quad \quad \left\{ \begin{aligned} (-\Delta )^s u -\theta \frac{u}{|x|^{2s}}&=u^p - u^q \quad \text {in }\,\, {\mathbb {R}}^N\\ u&> 0 \quad \text {in }\,\, {\mathbb {R}}^N\\ u&\in {\dot{H}}^s({\mathbb {R}}^N)\cap L^{q+1}({\mathbb {R}}^N), \end{aligned} \right. \end{aligned}$$

(
P
)

(
-
Δ
)

s

u
-
θ

u

|
x
|

2
s

=

u
p

-

u
q

in

R

N

u

>
0

in

R

N

u

∈

H
˙

s

(

R

N

)

∩

L

q
+
1

(

R

N

)

,

where $$s\in (0,1)$$

s
∈
(
0
,
1
)

, $$N>2s$$

N
>
2
s

, $$q>p\ge {(N+2s)}/{(N-2s)}$$

q
>
p
≥

(
N
+
2
s
)

/

(
N
-
2
s
)

, $$\theta \in (0, \Lambda _{N,s})$$

θ
∈
(
0
,

Λ

N
,
s

)

and $$\Lambda _{N,s}$$

Λ

N
,
s

is the sharp constant in the fractional Hardy inequality. For qualitative properties of the solutions, we mean both the radial symmetry, that is obtained by using the moving plane method in a nonlocal setting on the whole $$\mathbb {R}^N$$

R

N

, and a suitable upper bound behavior of the solutions. To this last end, we use a representation result that allows us to transform the original problem into a new nonlocal problem in a weighted fractional space.
Functional disability and utilisation of long-term care in the older population in England: a dual trajectory analysis
Authors: Hu Bo , Cartagena-Farias Javiera , Brimblecombe Nicola 
Published: August 2022

AbstractThis study investigates the developmental trajectories of long-term care needs and utilisation in older people aged 65 years and over in England. The data came from the English Longitudinal Survey of Ageing (ELSA, waves 6–9, 2012–2018, N = 13,425). We conducted dual trajectory analyses to cluster people’s trajectories of care needs (measured by functional disability) and utilisation into distinct groups. We conducted logistic regression analyses to identify the factors associated with trajectory memberships. We identified three trajectories of long-term needs (low, medium, and high) and three trajectories of care utilisation (low, medium, and high). Both care needs and care hours increased with age, but the speed of increase varied by trajectory. Females, minority ethnic groups, people with low wealth, and those experiencing housing problems were more likely to follow the joint trajectories characterised by higher care needs and higher care intensity. People with low or medium care needs stayed in the same trajectories of care utilisation. In contrast, people in the high-needs trajectory followed divergent trajectories of care utilisation: 63% of them followed the trajectory of high care intensity and the rest (37%) followed the trajectory of medium care intensity. Lack of spouse care was the leading predictor of trajectory divergence (OR = 3.57, p < 0.001). Trajectories of care needs and utilisation are highly heterogeneous in later life, which indicates persistent inequalities over time. Single people with multiple functional limitations face an acute and enduring risk of inadequate care and unmet needs. The amount of support is as important as the availability of support.
Forecast combinations for benchmarks of long-term stock returns using machine learning methods
Authors: Scholz Michael 
Published: August 2022

AbstractForecast combinations are a popular way of reducing the mean squared forecast error when multiple candidate models for a target variable are available. We apply different approaches to finding (optimal) weights for forecasts of stock returns in excess of different benchmarks. Our focus lies thereby on nonlinear predictive functions estimated by a fully nonparametric smoother with the covariates and the smoothing parameters chosen by cross-validation. Based on an out-of-sample study, we find that individual nonparametric models outperform their forecast combinations. The latter are prone to in-sample over-fitting and in consequence, perform poorly out-of-sample especially when the set of possible candidates for combinations is large. A reduction to one-dimensional models balances in-sample and out-of-sample performance.