bluuebunny/crossref_metadata_2025_split huggingface dataset:
The outcomes of Thirsty? Choose Water! Determining the effects of a behavioural and an environmental intervention on water and sugar sweetened beverage consumption in adolescents: A randomised controlled trial
Authors: Gowland‐Ella Justine , Batchelor Samantha , David Michael , Lewis Peter , Kajons Nicole 
Published: May 2022

AbstractIssue addressedChildhood obesity is a serious public health challenge. Consumption of sugar‐sweetened beverages (SSBs) is one contributing factor, with adolescents being the highest consumers.MethodsThis study used a randomised controlled trial and two‐by‐two factorial design to determine the effectiveness of a school‐based behavioural intervention (including education/promotional messages) and/or environmental intervention (chilled water station), on encouraging adolescents to choose water instead of SSBs. Sixty‐one secondary schools (n = 8992 eligible students year 7 student) were recruited and randomly allocated to one of four study groups, the behavioural intervention, the environmental intervention, both interventions or neither.ResultsThe primary outcome was increased water consumption; secondary outcomes included changes in students' knowledge and attitudes about water and SSBs and changes in SSB consumption. For students who received at least one intervention there was an increased odds (though not statistically significant) of higher water consumption compared to those that received no intervention. There was a decrease in SSB consumption for students who received both interventions combined (OR: 0.67; 95% confidence interval: 0.55‐0.082; P < .01).ConclusionsThe combined intervention had a greater effect on decreasing SSBs consumption. This is noteworthy given SSBs are a key contributor to overweight and obesity.So what?To our knowledge this is the first Australian study examining combined school‐based interventions to specifically promote the consumption of water and decrease the consumption of SSBs in adolescents. The study findings add to the evidence regarding the benefits of delivering multicomponent school‐based interventions which add value to existing interventions that address the complex public health issue of overweight and obesity.
Iron overload‐induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: An in vitro and in vivo study
Authors: Jiang Zengxin , Wang Hao , Qi Guobin , Jiang Chang , Chen Kangning , Yan Zuoqin 
Published: May 2022

AbstractGrowing evidence indicates that iron overload is an independent risk factor for osteoporosis. However, the mechanisms are not fully understood. The purpose of our study was to determine whether iron overload could lead to ferroptosis in osteoblasts and to explore whether ferroptosis of osteoblasts is involved in iron overload‐induced osteoporosis in vitro and in vivo. Ferric ammonium citrate was used to mimic iron overload conditions, while deferoxamine and ferrostatin‐1 were used to inhibit ferroptosis of MC3T3‐E1 cells in vitro. The ferroptosis, osteogenic differentiation and mineralization of MC3T3‐E1 cells were assessed in vitro. A mouse iron overload model was established using iron dextran. Immunohistochemical analysis was performed to determine ferroptosis of osteoblasts in vivo. Enzyme‐linked immunosorbent assays and calcein–alizarin red S labelling were used to assess new bone formation. Dual x‐ray absorptiometry, micro‐computed tomography and histopathological analysis were conducted to evaluate osteoporosis. The results showed that iron overload reduced cell viability, superoxide dismutase and glutathione levels, increased reactive oxygen species generation, lipid peroxidation, malondialdehyde levels and ferroptosis‐related protein expression, and induced ultrastructural changes in mitochondria. Iron overload could also inhibit osteogenic differentiation and mineralization in vitro. Inhibiting ferroptosis reversed the changes described above. Iron overload inhibited osteogenesis, promoted the ferroptosis of osteoblasts and induced osteoporosis in vivo, which could also be improved by deferoxamine and ferrostatin‐1. These results demonstrate that ferroptosis of osteoblasts plays a crucial role in iron overload‐induced osteoporosis. Maintaining iron homeostasis and targeting ferroptosis of osteoblasts might be potential measures of treating or preventing iron overload‐induced osteoporosis.
Surface modification of acrylic coating with anti‐corrosion and anti‐UV materials
Authors: Rezaei Abadchi Majid , Mirzaee Majid , Dorkhani Erfan , Zolriasatein Ashkan , Noori Nastaran Riahi 
Published: May 2022

AbstractThe use of organic coatings is the most common method of corrosion protection of metal structures in aggressive environments which act as a barrier between the corrosive environment and the metal structure. In this work, to increase the corrosion resistance and UV resistance of steel structures, an acrylic coating containing titanium oxide (TiO2), zinc phosphate (ZP), and benzophenone was used and the coating was characterized by open circuit potential (OCP) techniques, electrochemical impedance spectroscopy (EIS), dynamic polarization, Adhesive strength, salt spray, and UV weathering. The results showed that in the case of the acrylic sample, it has poor corrosion resistance and requires the presence of nanofillers. With the presence of TiO2 nanofillers, microporous and other defects were effectively blocked and the penetration of corrosive components into the interface of the metal coating and substrate was prevented. In the presence of ZP along with TiO2, all anodic and cathodic sites were coated with a film consisting of inhibitors released from zinc phosphate nanoparticles and thus acted as a barrier against electrolyte penetration into active metal sites. With the presence of an anti‐UV agent, benzophenone partially blocked surface defects and along with corrosion products prevented a sharp drop in resistance over longer periods.
Legitimacy, incipience, and perception of informal social control of intimate partner violence: Experiment on a Korean parent sample
Authors: Emery Clifton R. , Abdullah Alhassan , Wu Shali 
Published: May 2022

AbstractEvidence from a growing research literature on the causes and effects of informal social control (ISC) and bystander interventions carried out by nonprofessionals against intimate partner violence (IPV) shows anomalies and unexplained counterintuitive findings. This study employs a new experimental vignette design to examine the hypothesis: high bystander legitimacy (in the eyes of potential perpetrators) will moderate the effects of (1) incipient ISC and (2) perceived ISC, on parent's self‐estimated likelihood of perpetrating IPV. The data consist of 210 rural Korean parents randomly drawn from Kyunggi province using a three‐stage cluster probability proportional to size approach. Parents were randomly assigned to low and high incipient ISC, perceived ISC, and collective legitimacy conditions, following a 2 × 2 × 2 experimental vignette approach. Hypotheses were tested using regression models with standard errors corrected for district clusters. Incipient ISC was associated with significantly less self‐estimated likelihood of perpetrating IPV. An interaction between high bystander legitimacy and incipient ISC was negative (B = −8.88, p < 0.01). The interaction between perceived ISC and legitimacy was not significant. However, the interaction between perceived ISC and female gender was positively associated with self‐estimated likelihood of perpetrating IPV (B = 8.61, p < 0.05). The findings suggest that the presence of a legitimate bystander (whom the potential perpetrator believes has a legitimate right to be concerned about his or her family) may deter parents from perpetrating IPV. Programs to boost ISC and bystander intervention should include modules that strengthen collective legitimacy.
Catalytic oxidation of toluene by metal phthalocyanine loaded on cordierite honeycomb
Authors: Wang Yajuan , Liu Wenqiang , Zhang Juan , Bian Yuhang 
Published: May 2022

AbstractBACKGROUNDAs one of the common VOCs, toluene is not only hazardous to human health, leading to respiratory disease, cancers, but also harmful to the environment, causing destruction of the ozone layer, photochemical smog and global warming. Catalytic oxidation is one of the most advanced technologies for eliminating VOCs and can convert VOCs to benign components such as carbon dioxide (CO2) and water. As catalysts are important in the catalytic process, finding highly active, low cost catalysts is critical. Metal phthalocyanine(MPc) has potential practical value and wide application prospects as catalysts for its uniquely high catalytic activity and selectivity. Thus, four monolithic catalysts were prepared by impregnating MPc onto cordierite honeycomb.RESULTSCharacterization by scanning electron microscopy, X‐ray diffraction, Fourier transform infrared and energy‐dispersive X‐ray spectroscopy showed that the metal phthalocyanines were successfully loaded on the cordierite honeycomb. A fixed‐bed reactor was used to examine the catalytic oxidation effects of metal phthalocyanine species, catalyst amount, feed concentration, feed flow and temperature on toluene. The result showed that the catalytic activity of phthalocyanine iron (FePc) to toluene was better than other three MPcs. The optimal reaction conditions were 120 mg catalyst, 6.3 × 10−3 mol m−3feed concentration and 250 mL min−1 feed flow. The conversion of toluene increased with increasing temperature.CONCLUSIONFePc/C also had a good catalytic oxidation effect on different aromatic hydrocarbon compounds (benzene and 1,4‐dimethyl‐benzene). The oxidation products of the catalytic system were CO2 and H2O, which met the requirements of green chemistry. FePc/C is a promising catalytic material because it has high catalytic activity and can be operated in simple conditions, such as low temperatures. © 2022 Society of Chemical Industry (SCI).
LGL leukemia patients exhibit substantial protective humoral responses following SARS‐CoV‐2 vaccination
Authors: Cheon Heejin , Elghawy Omar , Shemo Bryna C. , Feith David J. , Loughran Thomas P. 
Published: May 2022

AbstractLarge granular lymphocyte leukemia is a rare chronic lymphoproliferative disorder of cytotoxic cells. Other hematological malignancies such as CLL and multiple myeloma have been associated with poor vaccination response and markedly increased severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) mortality rates, specifically in patients who have undergone immunosuppressive therapy. Given the immunosuppressive therapies often used to treat the disease, large granular lymphocytic (LGL) patients may be especially vulnerable to SARS‐CoV‐2 infection. A questionnaire was sent to all patients in the LGL Leukemia Registry at the University of Virginia (UVA) to obtain information on vaccination status, type of vaccine received, side effects of vaccination, patient treatment status before, during, and after vaccination, antibody testing, history of coronavirus disease 2019 (COVID‐19) infection, and presence or absence of booster vaccination. Antibody testing of 27 patients who had quantitative SARS‐CoV‐2 Spike Protein IgG levels determined by University of Virginia medical laboratories via the Abbott Architect SARS‐CoV‐2 IgG II assay were collected. The assay was scored as reactive at a threshold of ≥50.0 AU/mL or nonreactive with a threshold of <50.0 AU/mL. LGL patients without treatment as well as patients who held treatment prior to their vaccination have a robust humoral response to SARS‐CoV‐2 vaccines. Patients who did not hold their immunosuppressive treatments have signifigantly diminished vaccine response compared to those who held their immunosuppressive treatment. Our findings support a dual strategy of pausing immunotherapy during the vaccination window and administration of the SARS‐CoV‐2 booster to all LGL leukemia patients to maximize protective antibodies.
Interest of the preventive and curative use of defibrotide on the occurrence and severity of sinusoidal obstruction syndrome after hematopoietic stem cell transplant in children
Authors: Rudebeck Carl J. , Renard Cécile , Halfon‐Domenech Carine , Ouachée‐Chardin Marie , Philippe Michael , Valla Frederic V. , Bertrand Yves , Penel‐Page Mathilde 
Published: May 2022

AbstractDefibrotide (DF) is indicated for the treatment of severe sinusoidal obstruction syndrome (SOS) following hematopoietic stem cell transplantation (HSCT), but its prophylactic use against SOS is not recommended yet. This study describes the impact of the preventive and curative use of DF on reducing the incidence and severity of SOS in children. Patients aged 0–19 years, who received allogenic HSCT after myeloablative conditioning regimen with busulfan or total body irradiation in our comprehensive cancer center, between 2013 and 2017, were included. The Baltimore or modified Seattle criteria were used for SOS diagnosis. SOS was graded using the 2017 European Society for Blood and Marrow Transplantation classification defining severity criteria of SOS in children. SOS occurrence tended to decrease with prophylactic DF, but no significant difference was observed in terms of severity. When not treated with preventive DF, 50% (19/38) of the patients with SOS were graded severe to very severe, but only 37% (7/19) had organ dysfunction. Curative DF was administered at a median of 2 days post‐HSCT, for a median of 6.5 days. The absence of fatal SOS supports the use of early curative DF with acceptable toxicities and questions the optimal duration of DF treatment.
Long‐Term Outcomes in Head and Neck Paragangliomas Managed with Intensity‐Modulated Radiotherapy
Authors: Rougier Guillaume , Rochand Adrien , Bourdais Rémi , Meillan Nicolas , Tankere Frédéric , Herman Philippe , Riet François , Mazeron Jean‐Jacques , Burnichon Nelly , Lussey‐Lepoutre Charlotte , Jacob Julian , Simon Jean‐Marc , Maingon Philippe , Feuvret Loïc 
Published: May 2022

ObjectivesHead & Neck Paragangliomas have been historically relying on surgery mostly, with worsened quality of life and major sequelae. Conventional external radiation therapy seems to offer an equivalent control rate with a low toxicity profile. The aim of this study was to assess the safety and efficiency of intensity‐modulated radiation therapy in Head & Neck paragangliomas.MethodsThis is a retrospective monocentric study conducted in a referral center, including all patients treated with IMRT, whether as an exclusive or post‐operative treatment for a tympanic and jugular, carotid, or vagal paraganglioma. Data collection was performed through the manuscript and computerized medical files, including consultation, operative, imaging, pathological analyses, delineation, and treatment planning reports. Success was defined as the complete or partial regression or stabilization without progression, or relapse in accordance with the RECIST criteria. Acute toxicities and long‐term sequelae were assessed.ResultsOur cohort included 39 patients included between 2011 and 2021: 18 patients treated for a TJ PG (45.9%), 11 patients for a carotid PG (28.4%), and 9 for a vagal PG (23.1%). Twenty‐nine patients had IMRT as an exclusive treatment (74.4%), whereas 10 patients had a post‐operative complementary treatment (25.6%). Median follow‐up in our cohort was 2318 days (average = 2200 days, 237–5690, sd = 1281.9). Among 39 patients, 37 were successfully controlled with IMRT (94.8%), and the toxicity profile was low without any major toxicity.ConclusionIMRT seems an ideal treatment, whether exclusive or post‐operative for Head & Neck paragangliomas.Level of Evidence3 Laryngoscope, 133:607–614, 2023
Nozzle‐Pressurized Gyration: A Novel Fiber Manufacturing Process
Authors: Dai Yanqi , Ahmed Jubair , Delbusso Angelo , Edirisinghe Mohan 
Published: May 2022

AbstractAn innovative development of pressurized gyration is presented, incorporating a directional nozzle system. Thus, nozzle‐pressurized gyration is used to prepare polymeric fibers. In this work, three different polymeric fibers (polycaprolactone, polyvinylpyrrolidone, and polyethylene oxide) manufactured by the original pressurized gyration and nozzle‐pressurized gyration are compared. Under the same processing parameters (working pressure, rotational speed, and collection distance), nozzle‐pressurized gyration is proved to be a highly efficient spinning technology for uniform and uniaxially oriented fiber products. The effects of the spinning vessel geometry on the morphology and alignment of gyrospun fibers are elucidated. This work also reveals the relationship between fiber morphology and collection distance in nozzle‐pressurized gyration. Varying the collection distance provides a useful approach to the synthesis of uniform fibers with anisotropic arrangement.
Digital technologies and privacy: State of the art and research directions
Authors: Scarpi Daniele , Pizzi Gabriele , Matta Shashi 
Published: May 2022

AbstractDigital technologies have transformed every aspect of marketing and have brought consumer privacy front and center of research and discourse over the last two decades. Whereas companies and consumers have arguably benefited through the availability and use of data made possible by digitalization, consumer privacy‐related concerns raise compelling questions that researchers, companies, and policymakers are addressing. In this review paper, we review privacy related to digital technologies in marketing, highlighting the constantly evolving nature of the field. We provide an overview of the rich contributions made by the articles in the special issue on digital technologies and privacy, and the original insights they provide for researchers and practitioners in four domains—communication, retailing, pricing, and product personalization. We identify and outline future research directions in each of these four domains to expand our understanding of privacy at the intersection of psychology and marketing by motivating new scholarly research and providing actionable insights to managers and policymakers.
Grüne Chemie: Mit Gamma‐Valerolacton lösen
Authors: Kerkel Florian , Kunz Werner , Kanzler Walter 
Published: May 2022

AbstractFür die chemische Industrie hat der European Green Deal sinnvolle und gleichzeitig anspruchsvolle Ziele formuliert. Unternehmen gewinnen organische Lösungsmittel nach wie vor zum Großteil aus fossilen Ressourcen, weshalb es dringend nachhaltiger Alternativen bedarf.
Management of potato cyst nematodes with special focus on biological control and trap cropping strategies
Authors: Mhatre Priyank Hanuman , Divya K.L. , Venkatasalam E.P. , Watpade Santosh , Bairwa Aarti , Patil Jagadeesh 
Published: May 2022

AbstractPotato cyst nematodes (PCNs; Globodera spp.) are one of the most difficult pests of potato to manage worldwide. Indiscriminate use of pesticides and their hazardous effects discourage the use of many chemicals for the management of PCNs. As a result, biological control agents and trap crops have received more attention from growers as safer ways to manage PCNs. The biological control agents such as Pochonia chlamydosporia, Purpureocillium lilacinum, Trichoderma spp., Pseudomonas fluorescens, Bacillus spp., Pasteuria spp., and others are recognized as potential candidates for the management of PCNs. Moreover recently, the use of trap crop Solanum sisymbriifolium also showed promise by drastically reducing soil populations of PCNs. Integration of these management strategies along with other practices including identification, conservation, and multiplication of native antagonists, will facilitate efficient management of the PCNs in potato cropping system. Some of the promising research approaches that are being used against PCNs are addressed in this review. © 2022 Society of Chemical Industry.
The area under the effect curve as an efficacy determinant for anti‐infectives
Authors: Chen Chao , Lavezzi Silvia Maria , Iavarone Laura 
Published: May 2022

AbstractPharmacokinetic/pharmacodynamic (PK/PD) indices making use of area under the curve, maximum concentration, and the duration that in vivo drug concentration is maintained above a critical level are commonly applied to clinical dose prediction from animal efficacy experiments in the infectious disease arena. These indices make suboptimal use of the nonclinical data, and the prediction depends on the shape of the PK profiles in the animals, determined by the species‐specific absorption, distribution, metabolism, and elimination properties, and the dosing regimen used in the efficacy experiments. Motivated by the principle that efficacy is driven by pharmacology, we conducted simulations using a generalized pathogen dynamic model, to assess the properties of an alternative efficacy predictor: the area under the effect curve (AUEC), computed using in vitro PD and in vivo PK. Across a wide range of hypothetical scenarios, the AUEC consistently showed regimen‐independent strong correlation (R2 0.76–0.98) with in vivo efficacy, superior to all other indices. These findings serve as proof of concept that AUEC should be considered in practice as a translation tool for cross‐species dose prediction. Using AUEC for clinical dose prediction could also potentially cut down animal use by reducing or avoiding dose fractionation experiments.
Interaction mechanics model for screw‐drive wheel of granary robot traveling on the loose grain terrain
Authors: Jin Hangjia , Lin Jizhao , Wu Wenfu , Lu Yanhui , Han Feng , Shi Xinjian 
Published: May 2022

AbstractThe screw drive mechanism has excellent driving performance on soft terrain and it is a good application for granary robot traveling on the loose grain surface. The investigation on screw drive wheel‐terrain contact mechanics is necessary to predict the traveling performance of the novel Screw‐Drive Granary Robot. Because the motion of grain particles is extremely complex beneath the wheel in the space, shearing displacement is decomposed into the longitudinal and tangential shearing displacement in this paper, and the corresponding shearing stress is calculated separately. Then the screw‐drive wheel‐terrain contact mechanics theory based on terramechanics is established by integrating the normal stress and shearing stress. Through driving experiments on corn‐terrain, the slip sinkage is determined and the sinkage modeling is modified simultaneously considering both vertical load and slip to improve the accuracy of prediction. And the calculated total resistance and the bulldozing resistance show that there is a linear proportional coefficient between them and slope of the line is 2.74 in this case. Finally, the improved mathematical model for screw‐drive wheel is proposed, the average error of predicted resistive torque is 15.72% and the mean error of drawbar pull is 16.2%.