bluuebunny/crossref_metadata_2025_split huggingface dataset:
L‐OPA1 deficiency aggravates necroptosis of alveolar epithelial cells through impairing mitochondrial function during acute lung injury in mice
Authors: Jiang Hui‐Ling , Yang Hui‐Hui , Liu Yu‐Biao , Zhang Chen‐Yu , Zhong Wen‐Jing , Guan Xin‐Xin , Jin Ling , Hong Jie‐Ru , Yang Jin‐Tong , Tan Xiao‐Hua , Li Qing , Zhou Yong , Guan Cha‐Xiang 
Published: April 2022

AbstractNecroptosis, a recently described form of programmed cell death, is the main way of alveolar epithelial cells (AECs) death in acute lung injury (ALI). While the mechanism of how to trigger necroptosis in AECs during ALI has been rarely evaluated. Long optic atrophy protein 1 (L‐OPA1) is a crucial mitochondrial inner membrane fusion protein, and its deficiency impairs mitochondrial function. This study aimed to investigate the role of L‐OPA1 deficiency‐mediated mitochondrial dysfunction in AECs necroptosis. We comprehensively investigated the detailed contribution and molecular mechanism of L‐OPA1 deficiency in AECs necroptosis by inhibiting or activating L‐OPA1. First, our data showed that L‐OPA1 expression was downregulated in the lungs and AECs under the lipopolysaccharide (LPS) challenge. Furthermore, inhibition of L‐OPA1 aggravated the pathological injury, inflammatory response, and necroptosis in the lungs of LPS‐induced ALI mice. In vitro, inhibition of L‐OPA1 induced necroptosis of AECs, while activation of L‐OPA1 alleviated necroptosis of AECs under the LPS challenge. Mechanistically, inhibition of L‐OPA1 aggravated necroptosis of AECs by inducing mitochondrial fragmentation and reducing mitochondrial membrane potential. While activation of L‐OPA1 had the opposite effects. In summary, these findings indicate for the first time that L‐OPA1 deficiency mediates mitochondrial fragmentation, induces necroptosis of AECs, and exacerbates ALI in mice.
Blood‐circulating EV‐miRNAs, serum TARC, and quantitative FDG‐PET features in classical Hodgkin lymphoma
Authors: Drees Esther E. E. , Driessen Julia , Zwezerijnen Gerben J. C. , Verkuijlen Sandra A. W. M. , Eertink Jakoba J. , van Eijndhoven Monique A. J. , Groenewegen Nils J. , Vallés‐Martí Andrea , de Jong Daphne , Boellaard Ronald , de Vet Henrica C. W. , Pegtel Dirk M. , Zijlstra Josée M. 
Published: April 2022

AbstractBlood‐based biomarkers are gaining interest for response evaluation in classical Hodgkin lymphoma (cHL). However, it is unknown how blood‐based biomarkers relate to quantitative 18F‐FDG‐PET features. We correlated extracellular vesicle‐associated miRNAs (EV‐miRNA), serum TARC, and complete blood count (CBC) with PET features (e.g., metabolic tumor volume [MTV], dissemination and intensity features) in 30 cHL patients at baseline. EV‐miR127‐3p, EV‐miR24‐3p, sTARC, and several CBC parameters showed weak to strong correlations with MTV and dissemination features, but not with intensity features. Two other EV‐miRNAs only showed weak correlations with PET features. Therefore, blood‐based biomarkers may be complementary to PET features, which warrants further exploration of combining these biomarkers in prognostic models.
Asian rainfall anomaly patterns associated with interannual variations of early and peak summer rainfall over the Indochina Peninsula
Authors: Shi Yu , Wu Renguang , Kripalani Ramesh , Zhu Peijun 
Published: April 2022

AbstractThis study investigates the rainfall anomaly patterns over Asia associated with interannual variations of early summer (May–June) and peak summer (July–August) Indochina Peninsula (ICP) rainfall during 1979–2016. It is found that the early and peak summer rainfall variation in the ICP displays an out‐of‐phase relation to that in central Asia and central China, respectively. Analysis reveals that the out‐of‐phase early summer rainfall variation between the ICP and central Asia tends to occur in ENSO decaying years and the out‐of‐phase peak summer rainfall variation between the ICP and central China tends to occur in ENSO developing years. The early summer out‐of‐phase rainfall anomaly pattern between the ICP and central Asia forms due to a Rossby wave type response to anomalous heating extending from the ICP to northeast India, which is attributed to a combined influence of same sign sea surface temperature (SST) anomalies in the equatorial eastern Pacific and tropical southwestern Indian Ocean and opposite sign SST anomalies in the tropical western North Pacific. The peak summer out‐of‐phase rainfall variation between the ICP and central China forms due to a meridional atmospheric circulation pattern over East Asia and the western North Pacific, which is resulted from the combined impacts of opposite SST anomalies in the equatorial central Pacific and tropical southeastern Indian Ocean. Further analysis indicates that the out‐of‐phase rainfall variations between the ICP and central Asia in early summer and between the ICP and central China in peak summer may occur without anomalous tropical Indo‐Pacific SST forcing.
Benchmarking soil organic carbon to support agricultural carbon management: A German case study#
Authors: Drexler Sophie , Broll Gabriele , Flessa Heinz , Don Axel 
Published: April 2022

AbstractBackgroundSoil organic carbon (SOC) storage is highly variable across sites and primarily depends on site properties and land use. It is therefore difficult for farmers to evaluate the actual SOC status of a site. To aid the interpretation of measured SOC contents, easy‐to‐use frameworks for the assessment of SOC contents are needed.AimsThe aim of this study was to derive site‐specific SOC benchmarks for German mineral soils under agricultural use based on the dataset of the first German Agricultural Soil Inventory.MethodsThe dataset was stratified into 33 strata by land use, soil texture, C/N ratio and mean annual precipitation. Lower and upper SOC benchmarks were calculated for all strata (0.125 and the 0.875 quantile).ResultsThe SOC benchmark value ranges were lower for cropland (6.8–48.9 g kg–1) than for grassland (14.1–76.6 g kg–1), and increased with rising clay content and precipitation. Sandy soils with a wide C/N ratio and high SOC content due to their heathland or peatland history were divided into separate strata. The number of strata only decreased the SOC benchmark ranges slightly. Around 15–20 sites were required as a minimum to quantify SOC benchmarks for one stratum.ConclusionsThe presented framework is easy to use, requiring only four readily available stratification factors to perform a comparative classification of SOC contents. It allows farmers and extension services to compare where their measured SOC contents fall within the expected SOC value range for their site, and can thus help develop an initial evaluation of the SOC status of a site with regard to soil‐specific differences.
Stability and digestibility of encapsulated lycopene in different emulsion systems stabilized by acid‐modified soybean lipophilic protein
Authors: Sun Yuanda , Zhong Mingming , Sun Yufan , Li Yang , Qi Baokun , Jiang Lianzhou 
Published: April 2022

AbstractBACKGROUNDOwing to the harsh acidic environment of the stomach, acid‐resistant emulsion products have wide‐ranging applications in the food industry. Herein, natural soybean lipophilic protein (LP) was used to establish coarse emulsions, nanoemulsions, emulsion gels, and high internal phase Pickering emulsions (HIPPE) under acidic conditions. Furthermore, the carrying characteristics of the acid‐resistant emulsion system with lycopene were explored.RESULTSComparisons of particle sizes, potentials, microstructures, and rheology of the four carrier systems revealed that HIPPE has a single particle‐size distribution, the largest zeta potential, and an elastic gel‐like network structure. Comparison of encapsulation rates indicated that HIPPE had the best effect on encapsulating lycopene, reaching approximately 90%. The pH stability, storage stability, and simulated in vitro digestion experiments showed that the four emulsions that were stable under acidic conditions had good acid resistance. Among them, the acid‐induced LP‐stabilized HIPPE had the best storage stability and superior compatibility with the harsh acidic environment of the stomach, which not only achieved the purpose of delaying the release of lipids but also conferred better protection to lycopene in the gastric tract; moreover, it achieved the best bioavailability.CONCLUSIONLP‐stabilized HIPPE has the best stability and can yield better absorption and utilization of lycopene by the body. The results of this study are helpful for the development of acid‐resistant functional emulsion foods that are conducive to the absorption of lycopene. © 2022 Society of Chemical Industry.
Cloud stabilization of citrus fruit juices treated with purified pectin methylesterase inhibitor from lemon (Citrus limonL.)
Authors: Bakshi Gayatri , Ananthanarayan Laxmi 
Published: April 2022

AbstractBACKGROUNDCloud destabilization is a significant quality defect of cloudy fruit juices. A proteinaceous inhibitor (PMEI) of pectin methylesterase (PME), identified in lemon, with a fold purity of 89.13, was used to stabilize the cloud of freshly prepared sweet lime, orange, and lemon juice.RESULTSLemon PMEI was able to inhibit the PME activity of all three fruit juices. In this study addition of calculated amounts of lemon PMEI to the three juice systems was based on the total PME units present in each juice. Relative turbidity, viscosity, pH, and ζ ‐potential of the PMEI‐treated juices were stable, resulting in uniform distribution of cloud particles throughout the juice system. The sedimentation rate in PMEI treated juices was very low, with cloud particles having smaller particle size diameter.CONCLUSIONThis work demonstrates an alternative option that might create new potential to control the quality deterioration in cloudy fruit juices. © 2022 Society of Chemical Industry.
Strategies for optimal perioperative outcomes in gastric cancer
Authors: Engel Dominique , Saric Stefan , Minnella Enrico , Carli Franco 
Published: April 2022

AbstractCancer and surgery represent a major stress on the human body. Any condition that prevents patients from tolerating the physiological stress is a risk factor for poor outcome. There is a need to identify these impairments early in the process with a simple screening, followed by assessments that provide a holistic picture of the patient. The proposed path of multimodal prehabilitation acts synergistically with enhanced recovery after surgery care to achieve optimal patient outcomes.
Current role for cytoreduction and HIPEC for gastric cancer with peritoneal disease
Authors: Khan Hamza , Johnston Fabian M. 
Published: April 2022

AbstractGastric cancer (GC) is an aggressive malignancy with a high burden of peritoneal disease. Evidence regarding the use of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) to improve outcomes has been growing. However, given multiple limitations, there remains a lack of international consensus regarding the optimal treatment paradigm. This review article discusses the burden of peritoneal disease in GC patients and the role of CRS + HIPEC in all treatment intents—curative, prophylactic, and palliative.
Mechanisms and fluid dynamics of foraging in heterotrophic nanoflagellates
Authors: Suzuki‐Tellier Sei , Andersen Anders , Kiørboe Thomas 
Published: April 2022

AbstractHeterotrophic nanoflagellates are the main consumers of bacteria and picophytoplankton in the ocean. In their microscale world, viscosity impedes predator–prey contact, and the mechanisms that allow flagellates to daily clear a volume of water for prey corresponding to 106 times their own volume is unclear. It is also unclear what limits observed maximum ingestion rates of about 104 bacterial preys per day. We used high‐speed video microscopy to describe feeding flows, flagellum kinematics, and prey searching, capture, and handling in four species with different foraging strategies. In three species, prey handling times limit ingestion rates and account well for their reported maximum values. Similarly, observed feeding flows match reported clearance rates. Simple point force models allowed us to estimate the forces required to generate the feeding flows, between 4 and 13 pN, and consistent with the force produced by the hairy (hispid) flagellum, as estimated using resistive force theory. Hispid flagella can produce a force that is much higher than the force produced by a naked (smooth) flagellum with similar kinematics, and the hairy flagellum is therefore key to foraging in most nanoflagellates. Our findings provide a mechanistic underpinning of observed functional responses of prey ingestion rates in nanoflagellates.
Unlocking Coherent Control of Ultrafast Plasmonic Interaction
Authors: Bahar Eyal , Arieli Uri , Stern Maayan Vizner , Suchowski Haim 
Published: April 2022

AbstractStriking a metallic nanostructure with a short and intense pulse of light excites a complex out‐of‐equilibrium distribution of electrons that rapidly interact and lose their mutual coherent motion. Due to the highly nonlinear dynamics, the photo‐excited nanostructures can generate energetic photons beyond the spectrum of the incident beam, where the shortest pulse duration is traditionally expected to induce the greatest nonlinear emission. Here, these photo‐induced extreme ultrafast dynamics are coherently controlled by spectrally shaping a sub‐10 fs pulse within the timescale of coherent plasmon excitations. Contrary to the common perception, it is shown that stretching the pulse to match its internal phase with the plasmon‐resonance increases the second‐order nonlinear emission by >25%. The enhancement is observed only when shaping extreme‐ultrashort pulses (<20 fs), thus signifying the coherent electronic nature as a crucial source of the effect. A detailed theoretical framework that reveals the optimal pulse shapes for enhanced nonlinear emission regarding the nanostructures’ plasmonic‐resonances is provided. The demonstrated truly‐coherent plasma control paves the way to engineer rapid out‐of‐equilibrium response in solids state systems and light‐harvesting applications.
Cavitation and radiofrequency versus cryolipolysis on leptin regulation in central obese subjects: A randomized controlled study
Authors: Abdel‐Aal Nabil M. , Mostafa Mohamed S. E.M. , Saweres Joseph W. , Ghait Ramy S. 
Published: April 2022

AbstractBackground and ObjectiveTo investigate the efficacy of adding ultrasound cavitation and radiofrequency versus cryolipolysis to weight reduction program on leptin, insulin, waist circumference, skinfold, body weight in central obese subjects.Material and MethodsSixty centrally obese participants were randomly allocated into three equal groups. Subjects in the study group (I) received cavitation and radiofrequency plus dietary regimen, subjects in the second study group (II) received cryolipolysis in conjunction with the same diet program, and subjects in the control group (III) received the same dietary regimen only. Leptin, insulin level, waist circumference, skinfold, body weight, and body mass index were measured shortly before intervention techniques and 3 months afterward.ResultsThere were no statistically significant differences between cavitation plus radiofrequency and cryolipolysis on leptin and insulin levels after 3 months of intervention. However, statistically significant differences were found in waist circumference, skinfold, weight reduction, and body mass index in favor of the cavitation group (p < 0.05). In addition, both cavitation‐radiofrequency and cryolipolysis were statistically significantly different than the diet alone in favor of the study groups (p < 0.05) in all the outcome measures. Furthermore, there were statistically significant differences in all outcome measures (p < 0.05) when comparing the baseline and postintervention results in each group except for leptin level in the diet group (p = 0.14).ConclusionSubjects who underwent cavitation plus radiofrequency had better improvement on waist circumference, skinfold, and body mass index than subjects who received cryolipolysis. However, no differences were found between cavitation plus radiofrequency and cryolipolysis on leptin and insulin levels.
Some model theory of Th(N,·)$\operatorname{Th}(\mathbb {N},\cdot )$
Authors: Stonestrom Atticus 
Published: April 2022

Abstract‘Skolem arithmetic’ is the complete theory T of the multiplicative monoid . We give a full characterization of the ‐definable stably embedded sets of T, showing in particular that, up to the relation of having the same definable closure, there is only one non‐trivial one: the set of squarefree elements. We then prove that T has weak elimination of imaginaries but not elimination of finite imaginaries.
A Carboxymethyl Chitosan‐Based Double‐Crosslinking Hydrogel with Enhanced Antibacterial Properties for Accelerated Wound Healing
Authors: Mo Xinya , Huang Wen‐Can , Sun Shifeng , Chi Zhe , Ding Yuanyuan , Mao Xiangzhao 
Published: April 2022

AbstractHere, a novel double‐crosslinked hydrogel dressing with enhanced antibacterial and anti‐inflammatory activities is reported. Carboxymethyl chitosan is crosslinked with silane and Ca2+ to form a double‐crosslinked hydrogel, and silver nanoparticles are loaded to introduce antibacterial properties to the hydrogel. The covalent crosslinking preserves the integrity of the hydrogel matrix, while the ionic crosslinking dissipates the energy under deformation. It combines high stretchability, toughness, tissue adhesion, and antimicrobial function. This hydrogel exhibits excellent cytocompatibility and hemocompatibility. Moreover, in vitro and in vivo investigations demonstrate its efficacy in accelerating bacterial‐infected wound healing. Given its excellent cytocompatibility and mechanical properties, this hydrogel is anticipated to be widely used in bacteria‐associated wound management.
The impact of socioeconomic status on preferences for sustainable luxury brands
Authors: Kim Jungkeun , Park Jooyoung , Septianto Felix 
Published: April 2022

AbstractAs consumers become more aware of and concerned about the environmental impact of their consumption choices, an increasing number of luxury brands are now engaging in sustainability practices. This study examines factors influencing the effectiveness of embedding sustainability in luxury brands. Specifically, the research focus is the effect of childhood socioeconomic status on moderating consumer preferences for sustainable (vs. regular, nonsustainable) luxury brands. Four experimental studies using different product categories and luxury brands show that preferences for sustainable (vs. regular, nonsustainable) luxury brands are stronger among consumers with relatively low (vs. high) childhood socioeconomic status (Studies 1–4). Notably, these preference patterns are driven by differences in the perceived importance of cooperation in the community among consumers with low versus high childhood socioeconomic status (Study 3). However, these divergent patterns are attenuated when consumption involves the nonluxury brand category (Study 2), and when consumers experience a high‐threat environment (e.g., the COVID‐19 pandemic; Study 4). As such, the findings of this study contribute to the literature by shedding light on the conditions under which consumers show preferences for sustainable (vs. regular, nonsustainable) luxury brands, establishing a theoretically grounded mediator (importance of cooperation in the community) and moderator (perceived environmental threat).
Mutation spectrum of congenital heart disease in a consanguineous Turkish population
Authors: Dong Weilai , Kaymakcalan Hande , Jin Sheng Chih , Diab Nicholas S. , Tanıdır Cansaran , Yalcin Ali Seyfi Yalim , Ercan‐Sencicek A. Gulhan , Mane Shrikant , Gunel Murat , Lifton Richard P. , Bilguvar Kaya , Brueckner Martina 
Published: April 2022

AbstractBackgroundsWhile many studies agree that consanguinity increases the rate of congenital heart disease (CHD), few genome analyses have been conducted with consanguineous CHD cohorts.MethodsWe recruited 73 CHD probands from consanguineous families in Turkey and used whole‐exome sequencing (WES) to identify genetic lesions in these patients.ResultsOn average, each patient had 6.95 rare damaging homozygous variants, 0.68 of which are loss‐of‐function (LoF) variants. Seven patients (9.6%) carried damaging homozygous variants in five causal CHD genes. Six of those patients exhibited laterality defects (six HTX and one D‐TGA). Three additional patients (4.1%) harbored other types of CHD‐associated genomic alterations, which overall explained 13.7% (10/73) of the cohort. The contribution from recessive variants in our cohort is higher than 1.8% reported from a cohort of 2871 CHD subjects where 5.6% of subjects met the criteria for consanguinity.ConclusionsOur WES screen of a Turkish consanguineous population with structural CHD revealed its unique genetic architecture. Six of seven damaging homozygous variants in CHD causal genes occur in the setting of laterality defects implies a strong contribution from consanguinity to these defects specifically. Our study thus provided valuable information about the genetic landscape of CHD in consanguineous families in Turkey.
Improved behavioral modeling using augmented LSTM networks for ultra‐broadband mmWave PA
Authors: Wang Shijie , Geng MingQing , Yu Chao , Cai Jialin 
Published: April 2022

AbstractIn this article, a new behavioral modeling method based on augmented long‐short term memory (ALSTM) networks for ultra‐broadband millimeter‐wave power amplifiers (mmWave PAs), is proposed. The basic theory and modeling procedure of this technique are provided. Different optimization cores of the models are tested, and the optimal algorithm is chosen. Tradeoffs have been made to fix the optimal topology for the proposed modeling technique. To validate the proposed method, a 4‐carrier 320 MHz modulated signal was employed to excite a mmWave PA with the center frequency located at 41 GHz. Experimental results show that the proposed ALSTM model has better predictive capability when compared with the traditional and other existing machine learning modeling techniques.