bluuebunny/crossref_metadata_2025_split huggingface dataset:
Routing and secret key assignment for secure multicast services in quantum satellite networks
Authors: He Xinyi , Li Lin , Han Dahai , Zhao Yongli , Nag Avishek , Wang Wei , Wang Hua , Cao Yuan , Zhang Jie 
Published: January 2022

Multicast is an important service type in both terrestrial and space communication networks but has security issues because more than one destination node can receive information. Point-to-point quantum key distribution can be achieved end-to-end over long distances by using a quantum satellite (e.g., Micius) as a relay node. Hence, how to provide secret keys for remote multicast services and efficiently distribute secret keys between the source node and multiple destination nodes for long-distance secure multicast services (SMSs) has become a critical problem. In this paper, a quantum satellite network with a special node structure is designed to complete point-to-multipoint key distribution, and a point-to-multipoint satellite relay scheme is proposed. The weight information of the link is dynamically described by the method of auxiliary topology, and a satellite relay tree is constructed. Finally, this paper proposes a satellite relay algorithm for multicast services to route and allocate key resources to solve the problem of long-distance point-to-multipoint key relay and improve the success probability of multicast service requests. Simulation results show that the proposed algorithm can improve the success probability of SMS requests by about 51.32% in a static scenario and 17.33% in a dynamic scenario.
Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19
Authors: Traets Marissa J. M. , Nijhuis Roel H. T. , Morré Servaas A. , Ouburg Sander , Remijn Jasper A. , Blok Bastiaan A. , de Laat Bas , Jong Eefje , Herder Gerarda J. M. , Fiolet Aernoud T. L. , Verweij Stephan P. 
Published: January 2022

Background
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can manifest with varying disease severity and mortality. Genetic predisposition influences the clinical course of infectious diseases. We investigated whether genetic polymorphisms in candidate genes ACE2, TIRAP, and factor X are associated with clinical outcomes in COVID-19.

Methods
We conducted a single-centre retrospective cohort study. All patients who visited the emergency department with SARS-CoV-2 infection proven by polymerase chain reaction were included. Single nucleotide polymorphisms in ACE2 (rs2285666), TIRAP (rs8177374) and factor X (rs3211783) were assessed. The outcomes were mortality, respiratory failure and venous thromboembolism. Respiratory failure was defined as the necessity of >5 litres/minute oxygen, high flow nasal oxygen suppletion or mechanical ventilation.

Results
Between March and April 2020, 116 patients (35% female, median age 65 [inter quartile range 55–75] years) were included and treated according to the then applicable guidelines. Sixteen patients (14%) died, 44 patients (38%) had respiratory failure of whom 23 required endotracheal intubation for mechanical ventilation, and 20 patients (17%) developed venous thromboembolism. The percentage of TIRAP polymorphism carriers in the survivor group was 28% as compared to 0% in the non-survivor group (p = 0.01, Bonferroni corrected p = 0.02). Genotype distribution of ACE2 and factor X did not differ between survivors and non-survivors.

Conclusion
This study shows that carriage of TIRAP polymorphism rs8177374 could be associated with a significantly lower mortality in COVID-19. This TIRAP polymorphism may be an important predictor in the outcome of COVID-19.
Baseline clinical features of COVID-19 patients, delay of hospital admission and clinical outcome: A complex relationship
Authors: Dananché Cédric , Elias Christelle , Hénaff Laetitia , Amour Sélilah , Kuczewski Elisabetta , Gustin Marie-Paule , Escuret Vanessa , Saadatian-Elahi Mitra , Vanhems Philippe 
Published: January 2022

IntroductionDelay between symptom onset and access to care is essential to prevent clinical worsening for different infectious diseases. For COVID-19, this delay might be associated with the clinical prognosis, but also with the different characteristics of patients. The objective was to describe characteristics and symptoms of community-acquired (CA) COVID-19 patients at hospital admission according to the delay between symptom onset and hospital admission, and to identify determinants associated with delay of admission.MethodsThe present work was based on prospective NOSO-COR cohort data, and restricted to patients with laboratory confirmed CA SARS-CoV-2 infection admitted to Lyon hospitals between February 8 and June 30, 2020. Long delay of hospital admission was defined as ≥6 days between symptom onset and hospital admission. Determinants of the delay between symptom onset and hospital admission were identified by univariate and multiple logistic regression analysis.ResultsData from 827 patients were analysed. Patients with a long delay between symptom onset and hospital admission were younger (p<0.01), had higher body mass index (p<0.01), and were more frequently admitted to intensive care unit (p<0.01). Their plasma levels of C-reactive protein were also significantly higher (p<0.01). The crude in-hospital fatality rate was lower in this group (13.3%versus27.6%), p<0.01. Multiple analysis with correction for multiple testing showed that age ≥75 years was associated with a short delay between symptom onset and hospital admission (≤5 days) (aOR: 0.47 95% CI (0.34–0.66)) and CRP>100 mg/L at admission was associated with a long delay (aOR: 1.84 95% CI (1.32–2.55)).DiscussionDelay between symptom onset and hospital admission is a major issue regarding prognosis of COVID-19 but can be related to multiple factors such as individual characteristics, organization of care and severe pathogenic processes. Age seems to play a key role in the delay of access to care and the disease prognosis.
Reference centiles based on year-to-year changes for a longitudinal evaluation of motor performance in children and adolescents
Authors: Wessela Sven , Meigen Christof , Poulain Tanja , Sobek Carolin , Vogel Mandy , Möller Siegfried , Kiess Wieland 
Published: January 2022

Objectives
The aim was to evaluate the longitudinal course of motor skills development in children with a view to improve the understanding of intra-individual variance. Previous publications have been based on cross-sectional data or analyzed longitudinal studies in a cross-sectional manner.

Design
Longitudinal. Year-to-year change.

Methods
The present study is based on motor function data collected in the LIFE Child study (Germany). The participants (6 to 17 years) completed parts of the motor tests according to the standard of the German Motor Performance Test 6–18 (DMT). For a total of 1653 participants, 4616 motor tests with an annual interval in the period 2011 to 2019 were included in the evaluation.

Results
We were able to produce gender and age-specific change centiles for the test items standing long jump, jumping sideways, push-ups, stand and reach and balancing walking backwards. Each set of centiles revealed a range of variability in motor development in children and adolescents, with distinct progressive patterns in the different test items and different genders. The supplied tables offer an indication of expected year-to-year change for each test item depending on age and gender. Depending on the test item and the mean age, a deterioration in test results after a one-year interval was observed, despite cross-sectional centiles showing an upward trend.

Conclusion
We present a user-friendly tool as a way to assess individual dynamic changes in motor development of children and adolescents. In combination with the well-known cross-sectional centiles as baseline, this can be helpful for the scientific evaluation of motor skills tests and can also be used in school settings.
Assessing the efficacy of an integrated intervention to create demand for fishermen’s schistosomiasis and HIV services (FISH) in Mangochi, Malawi: Study protocol for a cluster randomized control trial
Authors: Conserve Donaldson F. , Kayuni Sekeleghe , Kumwenda Moses K. , Dovel Kathryn L. , Choko Augustine Talumba 
Published: January 2022

Background
Both HIV and schistosomiasis are major public health problems worldwide with 1.8 million new HIV infections, and up to 110 million untreated schistosomiasis cases globally. Although a causal link has not been established, there are strong suggestions that having schistosomiasis increases onward transmission of HIV from co-infected men to women. With both HIV and schistosomiasis treatment readily available in Malawi, there is a need to investigate the feasibility, acceptability and health impacts of joint management of these two hazards, with special focus on health education and demand-creation for fishermen. The aim of this project is to identify optimal models of delivering integrated HIV and schistosomiasis services for fishermen, particularly investigating the effect of using social networks, HIV self-test kits and beach clinic services in Mangochi, Malawi.

Methods
We have mapped 45 boat teams or landing sites for a 3-arm cluster randomized trial using “boat team” as the unit of randomization. The three arms are: 1) Standard of care (SOC) with leaflets explaining the importance of receiving presumptive treatment for schistosomiasis (praziquantel) and HIV services for fishermen, and two intervention arms of 2) SOC + a peer explaining the leaflet to his fellow fishermen in a boat team; and 3) arm 2 with HIV self-test kits delivered to the boat team fishermen by the peer. The primary outcomes measured at 9 months of trial delivery will compare differences between arms in the proportions of boat-team fishermen: 1) who self-report starting antiretroviral therapy or undergoing voluntary medical male circumcision; and 2) who have ≥1 S. haematobium egg seen on light microscopy of the filtrate from 10mls urine (“egg-positive”).

Discussion
This is the first evaluation of an integrated HIV and schistosomiasis services intervention for fishermen, particularly investigating the effect of using social networks, HIVST kits and beach clinic services. The findings will support future efforts to integrate HIVST with other health services for fishermen in similar settings if found to be efficacious.

Trial registration
This trial is registered in the ISRCTN registry: ISRCTN14354324; date of registration: 05 October 2020. https://www.isrctn.com/ISRCTN14354324?q=ISRCTN14354324&filters=&sort=&offset=1&totalResults=1&page=1&pageSize=10&searchType=basic-search.
Linked to protocol version number 1.4 of 11 January 2021.
The association between geriatric treatment and 30-day readmission risk among medical inpatients aged ≥75 years with multimorbidity
Authors: Wang-Hansen Marte Sofie , Kersten Hege , Benth Jūratė Šaltytė , Wyller Torgeir Bruun 
Published: January 2022

Background
Readmission to hospital is frequent among older patients and reported as a post-discharge adverse outcome. The effect of treatment in a geriatric ward for acutely admitted older patients on mortality and function is well established, but less is known about the possible influence of such treatment on the risk of readmission, particularly in the oldest and most vulnerable patients. Our aim was to assess the risk for early readmission for multimorbid patients > 75 years treated in a geriatric ward compared to medical wards and to identify risk factors for 30-day readmissions.

Methods
Prospective cohort study of patients acutely admitted to a medical department at a Norwegian regional hospital. Eligible patients were community-dwelling, multimorbid, receiving home care services, and aged 75+. Patients were consecutively included in the period from 1 April to 31 October 2012. Clinical data were retrieved from the referral letter and medical records.

Results
We included 227 patients with a mean (SD) age of 86.0 (5.7) years, 134 (59%) were female and 59 (26%) were readmitted within 30 days after discharge. We found no statistically significant difference in readmission rate between patients treated in a geriatric ward versus other medical wards. In adjusted Cox proportional hazards regression analyses, lower age (hazard ratio (95% confidence interval) 0.95 (0.91–0.99) per year), female gender (2.17 (1.15–4.00)) and higher MMSE score (1.03 (1.00–1.06) per point) were significant risk factors for readmission.

Conclusions
Lower age, female gender and higher cognitive function were the main risk factors for 30-day readmission to hospital among old patients with multimorbidity. We found no impact of geriatric care on the readmission rate.
Novel Hemostatic Gel As Rescue Therapy for Postsphincterotomy Bleeding Refractory to Self-Expanding Metallic Stent Placement
Authors: Gagliardi Mario , Oliviero Giovanni , Fusco Michele , Napoli Marco , Sica Andrea , Maurano Attilio , Sica Mariano , Zulli Claudio 
Published: January 2022

ABSTRACT
Endoscopic sphincterotomy (ES) is commonly performed during endoscopic retrograde cholangiopancreatography, and bleeding is a severe adverse event. PuraStat is a peptide developed as a hemostatic agent for endoscopy. We report its use as a hemostatic strategy in post-ES bleeding refractory to combined hemostasis. A patient with choledocholithiasis underwent endoscopic retrograde cholangiopancreatography for stone removal. After the ES, severe bleeding refractory to the injection of diluted epinephrine around the bleeding source and metal stent placement occurred. Hemostasis was achieved with the application of the hemostatic gel. We reported the use of novel self-assembling hemostatic gel as an effective therapeutic tool for post-ES refractory bleeding.
Dampak Sosial, Ekonomi dan Lingkungan Pertambangan Pasir di Desa Luragung Landeuh Kuningan, Jawa Barat
Authors: Waniatri Wina , Muslihudin Muslihudin , Lestari Sri 
Published: January 2022

Permasalahan dan isu strategis daerah pada bidang energi dan sumber daya mineral yang mempengaruhi kerusakan lingkungan hidup berdasarkan pada Rancangan Primer RPJMD 2018-2028 Kabupaten Kuningan yaitu kegiatan penambangan pasir ilegal dan perubahan lahan. Salah satu lokasi pertambangan di Kabupaten Kuningan berada di Desa Luragung Landeuh. Penelitian ini dilakukan untuk mengetahui proses kegiatan pertambangan pasir; serta mengetahui dampak negatif pertambangan pasir terhadap kualitas lingkungan. Penelitian ini menggunakan metode analisis deskriptif kualitatif. Kesimpulan penelitian ini adalah proses kegiatan pertambangan pasir PT. Anggun Jaya Mandiri di Desa Lurangung Landeuh Kecamatan Luragung Kabupaten Kuningan terdiri dari tahap pra-kontruksi, kontruksi, operasi, produksi, dan rencana pasca tambang. Dampak negatif kegiatan pertambangan pasir terhadap lingkungan adalah kebisingan, debu yang bertebaran, kerusakan infrastruktur jalan; Dampak positif kegiatan pertambangan pasir PT.AJM memberikan peningkatan peluang kerja, memperbaiki fasilitas desa, serta meningkatkan kas Desa Luragung Landeuh. Pandemi Covid-19 pada awal tahun 2020 telah mempengaruhi dalam penyelesaian konflik antara masyarakat dan pihak perusahaan pertambangan.ABSTRACTRegional strategic problems and issues in the field of energy and mineral resources that affect environmental damage based on the Primary Draft RPJMD 2018-2028 Kuningan Regency, namely illegal sand mining activities and land changes. One of the mining locations in Kuningan Regency is in Luragung Landeuh Village. This research was conducted to determine the process of sand mining activities; as well as knowing the negative impact of sand mining on environmental quality. This study uses a qualitative descriptive analysis method. The conclusions of this study are: (1) The process of sand mining activities of PT. Anggun Jaya Mandiri in Lurangung Landeuh Village, Luragung District, Kuningan Regency consists of pre-construction, construction, operation, production, and post-mining planning stages. The negative impacts of sand mining activities on the environment are noise, scattered dust, damage to road infrastructure; (2) The positive impact of PT.AJM's sand mining activities provides increased job opportunities, improves village facilities, and increases the cash flow of Luragung Landeuh Village. The Covid-19 pandemic at the beginning of 2020 has affected the resolution of conflicts between the community and the mining company.
The effect of retirement on social relationships
Authors: Comi Simona Lorena , Cottini Elena , Lucifora Claudio 
Published: January 2022

Abstract
We analyze the causal effect of retirement on individual social relationships using data from the Survey of Health, Ageing and Retirement in Europe. We find that retirement changes the composition of the individual’s social network, inducing a substitution between weak (friends or colleagues) and strong ties (family), along with an increase in the intensity of the surviving ties, and there is no effect on the network’s size. These changes in the social network’s composition are associated with a higher satisfaction and stronger relationships. Interestingly, females reduce the share of friends while males that of colleagues.
Quality of life and academic resilience of Filipino nursing students during the COVID-19 pandemic: a cross-sectional study
Authors: Berdida Daniel Joseph E. , Grande Rizal Angelo N. 
Published: January 2022

Abstract

Objectives
Studies on quality of life (QoL) and academic resilience among nursing students during the Coronavirus disease (COVID-19) pandemic remain underreported. This study investigated the relationship between nursing students’ QoL and academic resilience and their predictors during the COVID-19 pandemic.

Methods
A descriptive survey, cross-sectional study that used two self-reported questionnaire scales to evaluate the QoL and academic resilience of Filipino nursing students (n=924). Chi-squared test and multiple regression were used to analyze the data.

Results
There was no significant association between the QoL and academic resilience to participants’ profile variables. Gender and year level of nursing students were significant predictors of QoL and academic resilience.

Conclusions
Our study concludes that a better understanding of the QoL and academic resilience, which are two distinct concepts critical in developing a student’s mental well-being, will help stakeholders in nursing education establish effective psychoeducation programs for nursing students.
Antibody-dependent enhancement of virus infection and disease: implications in COVID-19
Authors: Shukla Ajay Kumar , Misra Saurav 
Published: January 2022

Abstract
Antibody-dependent enhancement (ADE) can be seen in a variety of viruses. It has a deleterious impact on antibody treatment of viral infection. This effect was first discovered in the dengue virus, and it has since been discovered in the coronavirus. Over 213 million people have been affected by the rapid spread of the newly emerging coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19). The new coronavirus offers a significant threat and has sparked widespread concern. ADE in dengue virus and other viruses are discussed with possible effect on COVID-19 treatment and vaccine development will need to consider this phenomenon to ensure it is mitigated and avoided altogether. In these case scenarios, the role of ADE and its clinical consequences remains to be explored for this newly detected virus.
Cranial manipulation affects cholinergic pathway gene expression in aged rats
Authors: Anandakrishnan Ramu , Tobey Hope , Nguyen Steven , Sandoval Osscar , Klein Bradley G. , Costa Blaise M. 
Published: January 2022

Abstract

Context
Age-dependent dementia is a devastating disorder afflicting a growing older population. Although pharmacological agents improve symptoms of dementia, age-related comorbidities combined with adverse effects often outweigh their clinical benefits. Therefore, nonpharmacological therapies are being investigated as an alternative. In a previous pilot study, aged rats demonstrated improved spatial memory after osteopathic cranial manipulative medicine (OCMM) treatment.

Objectives
In this continuation of the pilot study, we examine the effect of OCMM on gene expression to elicit possible explanations for the improvement in spatial memory.

Methods
OCMM was performed on six of 12 elderly rats every day for 7 days. Rats were then euthanized to obtain the brain tissue, from which RNA samples were extracted. RNA from three treated and three controls were of sufficient quality for sequencing. These samples were sequenced utilizing next-generation sequencing from Illumina NextSeq. The Cufflinks software suite was utilized to assemble transcriptomes and quantify the RNA expression level for each sample.

Results
Transcriptome analysis revealed that OCMM significantly affected the expression of 36 genes in the neuronal pathway (false discovery rate [FDR] <0.004). The top five neuronal genes with the largest-fold change were part of the cholinergic neurotransmission mechanism, which is known to affect cognitive function. In addition, 39.9% of 426 significant differentially expressed (SDE) genes (FDR<0.004) have been previously implicated in neurological disorders. Overall, changes in SDE genes combined with their role in central nervous system signaling pathways suggest a connection to previously reported OCMM-induced behavioral and biochemical changes in aged rats.

Conclusions
Results from this pilot study provide sufficient evidence to support a more extensive study with a larger sample size. Further investigation in this direction will provide a better understanding of the molecular mechanisms of OCMM and its potential in clinical applications. With clinical validation, OCMM could represent a much-needed low-risk adjunct treatment for age-related dementia including Alzheimer’s disease.
High-performance near-infrared photodetectors based on gate-controlled graphene–germanium Schottky junction with split active junction
Authors: Kim Cihyun , Yoo Tae Jin , Kwon Min Gyu , Chang Kyoung Eun , Hwang Hyeon Jun , Lee Byoung Hun 
Published: January 2022

Abstract
The structure of a gate-controlled graphene/germanium hybrid photodetector was optimized by splitting the active region to achieve highly sensitive infrared detection capability. The strengthened internal electric field in the split active junctions enabled efficient collection of photocarriers, resulting in a responsivity of 2.02 A W−1 and a specific detectivity of 5.28 × 1010 Jones with reduced dark current and improved external quantum efficiency; these results are more than doubled compared with the responsivity of 0.85 A W−1 and detectivity of 1.69 × 1010 Jones for a single active junction device. The responsivity of the optimized structure is 1.7, 2.7, and 39 times higher than that of previously reported graphene/Ge with Al2O3 interfacial layer, gate-controlled graphene/Ge, and simple graphene/Ge heterostructure photodetectors, respectively.