bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life and mood disorders
Authors: Smaoui N. , Lajmi I. , Guermazi A. , Omri S. , Feki R. , Bouali M. Maalej , Charfi N. , Thabet J. Ben , Zouari L. , Maalej M. 
Published: February 2022

IntroductionMany researches addressing quality of life (QOL) has been demonstrated its impairment during acute episodes of bipolar disorder (BD) and major depressive disorder (MDD).ObjectivesTo compare QOL between patients with remitted MDD and remitted BD and healthy controls (HC).MethodsA comparative and analytical study, conducted over 3 months in the outpatient psychiatric department of Hedi Chaker University Hospital in Sfax (Tunisia) among 30 patients with remitted BD, 30 patients with remitted MDD and 34 HC. QOL was assessed with the «36 item Short-Form Health Survey» (SF-36).Results
Compared with HC, the MDD and the BD groups had significantly lower scores for the total of the SF-36 and its sub-domains (table 1). Physical scores were lower in patients with MDD, compared with patients with BD (table 1). Table 1: Comparison of SF-36 sub-domain scores between MDD, BD patients, and HC.Sub-domains of the SF36MDDBDHCPMean physical score - Physical functioning - limitation due to physical health - Pain - General health45.5 67 42.5 60 48.559,28 69,00 44,17 67,13 56,8377,86 84,26 71,03 83,50 72,050.000 0.003 0.005 0.001 0.000Mean psychic score - limitation due to emotional problems - Social functioning - Energy/fatigue - Emotional well-being
47.25 41 55.8 40 5248,19 48.89 43.48 46.5 53.8668,66 76.97 75.52 56.02 66.120,000 0.000 0.000 0.002 0.007Mean global score50.8853,7373,780,000ConclusionsQOL of patients with mood disorders such as MDD and BD suffered damage even in euthymic periods.
Terbinafine and antidepressants: Potential risk of medication induced mania
Authors: Barbosa P. , Nombora O. , Monteiro J. , Ribeiro L. 
Published: February 2022

Introduction
Mood destabilization and induced manic episodes are well-known phenomenon under antidepressant medications. However, even with a cautious introduction of antidepressants, it’s important to be aware of possible pharmacological interactions. Terbinafine is a known inhibitor of CYP2D6, a major hepatic metabolizer of a full list of antidepressant medications, and so capable of raising their serum levels and potentiating their side effects.ObjectivesWith this case report we aim to emphasize the importance of cautious usage of Terbinafine when combined with antidepressant medications.MethodsWe present a clinical case of an induced first manic episode after the introduction of Terbinafine in a patient under antidepressant medication and a qualitative review on the topic, using PubMed database.ResultsA 66-year-old woman, with an history of Major Depressive Disorder, previously medicated with Venlafaxine 75mg/day and Mirtazapine 30mg/day, was brought to the emergency department because of psychomotor agitation. She also had an history of seasonal fluctuating mood, although never fulfilling the criteria for Bipolar Disorder. At admission, her clinical status was compatible with a manic episode. This episode followed two months after the initiation of Terbinafine for onychomycosis.Conclusions
There are few studies that have shown antidepressant toxicity mediated by an interaction with Terbinafine. As far as we know this is the first case of induced mania after the introduction of Terbinafine. Therefore, it is important to remind that Terbinafine is a potential interacting agent when combined with psychotropic medications.
Comparative study of affective temperaments between medical students and humanities students(evaluation by validated temps-a)
Authors: Jomli R. , Ouertani J. , Jemli H. , Ouali U. , Zgueb Y. , Nacef F. 
Published: February 2022

Introduction
While the links between cyclothymia and creativity are well documented, the experts have tried to determine whether temperament would influence the major choices of life such as career.ObjectivesThe study aims mainly to evaluate the temperaments of a sample of Tunisian students, and to look for the possible correlations between the temperament and the choice of studies.MethodsThe Tunisian version of the TEMPS-A which is a self-evaluation measure to assess affective temperaments was administered to 100 medical students and 100 humanities students.ResultsStudent populations differed in their socio-demographic and scholar variables such as age, sex ratio or socio-economic level, choice of studies and their religiosity. The temperamental prevalences were close between our two populations by considering the threshold score Mean +1standard deviation; they ranged between 13 and 18%. Hyperthymic and cyclothymic scores were significantly higher among humanities students (11.38 ± 4.385 versus 9.00 ± 4.192 and 11.96 ± 4.497 versus 9.63 ± 4.499 respectively) and irritable scores were higher in the latter, though not significant (6.45 ± 3.823 versus 5.39 ± 2.998). Depressive and anxious temperament scores were close in both groups. The study showed significant temperament differences within gender, socioeconomic status, high school marks, religiosity and political affiliation.ConclusionsIt is relevant and even necessary to include such studies in the selection of candidates who could adapt to a specific professional field on the basis of objective criteria such as conscientiousness, and privileging profile diversity.
Screening for a false unipolarity in patients treated for a major depressive disorder
Authors: Regaieg N. , Baati I. , Amor F. Ben , Kallel M. , Hentati S. , Masmoudi J. 
Published: February 2022

Introduction
The early diagnosis of bipolar II disorder remains difficult in clinical practice, hence the importance of psychometric tests.ObjectivesTo detect hypomania in patients followed for a major depressive disorder (MDD) and to determine factors which are correlated with it.MethodsThis was a cross-sectional, descriptive and analytical study. It involved 40 psychiatric outpatients, who were followed for MDD (isolated or recurrent episode) at the Hedi Chaker University Hospital in Sfax (Tunisia), from January 26 to February 10, 2020. The study was conducted using a questionnaire and the Angst Hypomania Checklist-20 (HCL-20).Results
The sex ratio (M/F) was 0.66 with an average age of 54.8 years. MDD started at an average age of 41.45 years. According to HCL-20, half of our sample had hypomania. The presence of hypomania was correlated with young age (p = 0.022), academic failure (p = 0.038) and smoking (p = 0.003). In addition, there was a statistically significant relationship between the presence of hypomania and the characteristics of the disease: number of depressive episodes ≥ 2 (p = 0.013), psychotic features (p = 0.038), melancholic features (p=0,025) and premature discontinuation of treatment (p = 0.003).ConclusionsOur study confirmed that bipolar depression is still underdiagnosed and poorly treated. Questioning a patient about a history of hypomania would be a delicate task and would require the help of a scale, in particular the HCL -20.
Specificities of bipolar depression in psychiatric inpatients
Authors: Kacem M. , Khouadja S. , Brahim S. , Betbout I. , Zarrouk L. 
Published: February 2022

IntroductionBipolar depression is not strictly clinically identical to unipolar depression.ObjectivesTo describe the clinical characteristics of patients with bipolar depression and to identify factors linked to bipolar depression.MethodsThis is a cross-sectional, descriptive and comparative study carried out at the psychiatric department of the University Hospital of Mahdia. We have included 26 patients with bipolar depression and have compared them to 26 patients with unipolar depression. The data were collected from patients’ medical files. The analytical study has been made using Chi2 tests. The threshold of p<0.05 was considered as significant.Results
The mean age was 45 years. The majority of patients were male (61.5%) and unemployed (69.2%). Half of the patients were married. Alcohol consumption was found in 30.8% of cases. Family history of bipolar disorder and attempted suicide were present in 27% and 11.5% of cases respectively. A hospitalization number greater than or equal to 4 was found in 54% of cases. Personal history of suicide attempts was found in 46.2% of cases. At the psychiatric examination, psychomotor retardation, anxiety and psychotic and atypical characteristics were present in 73%, 31%, 42.3% and 7.7% of cases respectively. 46.2% of patients were treated with antidepressants in combination with a mood stabilizer. Antipsychotic treatment was combined in 80.8% of cases. A significant difference was noted for the number of hospitalizations, anxiety and antipsychotic treatment.ConclusionsAn early distinction between bipolar and unipolar disorders is crucial for the treatment of both diseases.
Music composers and bipolar disorders: Where do we stand?
Authors: Giannouli V. 
Published: February 2022

IntroductionThe intersection between bipolar disorders and creativity has been investigated in western literature. Although psychopathology has been proposed for famous artists in painting, writing, music and other forms of art, there is no systematic study examining bipolar disorders and music production in composers.ObjectivesThe aim of this review is to investigate this relationship by providing an overview of published studies.MethodsThe search included papers published in English as abstracts as well as in full length until October 2020. The literature search was conducted using the MEDLINE, EMBASE, PUBMED and GOOGLE SCHOLAR databases. For all the searches, the terms/key words that were used were “bipolar disorder”, “music”, “creativity”, and “composers”.ResultsSearch results for composers from different music genres and musical periods indicated that the proposed origin of the overall bipolar pattern is attributed to several stressful environmental factors which are taking the form of interpersonal problems regarding the expressed emotion, life events, and paucity of stress-management skills. In addition to that, bipolar psychopathological patterns seem to influence the quantity of music composing activity indirectly due to changes in everyday functional abilities.ConclusionsPublished reports, although based on biographical research, do provide evidence in support of a strong bipolarity-music creativity/production link for famous composers. Further well-designed studies in living music professionals engaged in music composition are needed.
Suicidality in women
Authors: Wasserman D. 
Published: February 2022

Every year, around 800,000 people die by suicide globally. Whist suicide mortality rates are higher among men, women typically have higher rates of suicidal ideation and behaviours. Despite this fact, suicidality in women is still of grave concern as 71% of women’s violent deaths is accounted for by suicide – a greater percentage than men’s. Suicide patterns among women differ between countries and regions. For example, there is a greater difference in suicide rates between men and women in high-income countries in comparison to low- and middle-income countries. Furthermore, many theories exist to explain women’s suicidality. Yet many of the dominant theories have been challenged from studies in both low- to middle-income and high-income countries. Further research that focuses on the context and culture, rather than the individual, is warranted and will be important for preventative efforts of women’s suicidal behaviours.DisclosureNo significant relationships.
Subsyndromal symptoms in bipolar disorder
Authors: Mellouli A. , Feki R. , Omri S. , Smaoui N. , Bouali M. Maalej , Charfi N. , Thabet J. Ben , Zouari L. , Maalej M. 
Published: February 2022

Introduction
The inter-critical phase in bipolar disorder may contain symptoms that do not meet the diagnostic criteria for a thymic episode. According to studies, these symptoms are common and usually associated with impaired psychosocial and family functioning.ObjectivesStudy the subsyndromal symptoms in remitted patients with bipolar disorder, and their functioning repercussions.MethodsWe conducted a cross-sectional, descriptive and analytical study, in the outpatient psychiatry department of the University Hospital in Sfax (Tunisia) among 30 remitted patients with bipolar disorder. We used: the Montgomery And Asberg Depression Rating Scale (MADRS), the Angst Hypomania Questionnaire and the FAST test to assess functioning levels.ResultsThe average age of our population was 44.37±15.45 years with a sex ratio (M/F) =0.66. Most of them lived in urban areas (60%) and half of them did not go beyond the primary school level. Most did not have a constant job (76.6%). The average number of previous thymic episodes was 2±1.33 times/year. A quarter of the patients (26.6%) had hypomanic symptoms in the intercritical phase and 20% had depressive symptoms. Hypomanic symptoms were correlated with tobacco use (p=0.035). Depressive symptoms weremore frequent in men (p=0.074). Functioninglevel was lower in subjects living in rural areas (p=0.065).ConclusionsOur study suggests that residual symptoms were frequent with a significant functional impact. As a result, their identification and management are highly essential to improve the overall functioning of patients with bipolar disorder.
Non-suicidal self-injury and impulsivity: Study of inibithory control in adolescent population
Authors: Pacifici S. , Baglioni V. , Cammisa L. , Guerrini D. , Mancini C. , Mirabella G. , Terrinoni A. 
Published: February 2022

IntroductionNon-suicidal self-injury (NSSI) is a clinical condition defined as intentional, self-inflicted act causing pain or superficial damage without suicidal intents (12-35% of the adolescent community). Several findings show a high correlation between NSSI and impairments in the impulsivity control.ObjectivesThe goal of our study is to evaluate the role of impulsivity in NSSI adolescents, relatively to the inhibitory control, in order to investigate if it can represent a neurocognitive risk factor underlying maladaptive behaviours and which psychopathological dimensions can be associated with this neurobiological process.Methods30 NNSI inpatients (age range: 12 to 18 years), drug-free, were compared with an age-matched control group, using two behavioural paradigms for the study of inhibitory control: the Stop Signal task and the emotive go/Nogo. Psychopathological traits were evaluated by self-report questionnaires for impulsivity dimensions, suicidality and self-injurious acts. Statistical analyses were performed with SPSS program (p =0.05).ResultsNSSI patients did not present impairments in the global inhibitory control but they had longer movement times in both paradigms and faster reaction times in the Go/no-go behavioural paradigm. Therefore, NSSI patients tended to be impulsive at an early stage of movement (rapid TR) and have to slow down in a second phase (TM slow) in order to have time to rework the cognitive processes underlying movement.ConclusionsThe impulsivity dimension is a complex construct that involves multiple interconnected factors. The study of neuro-cognitive and psychopathological aspects and how they are interconnected is necessary to draw new perspectives on the etiopathogenesis of NNSI.
Microbiome - a (FUTURE) marker for the differential diagnosis for autism spectrum disorder and attention-deficit/hyperactivity disorder?
Authors: Ramos I. , Figueiredo-Braga M. 
Published: February 2022

IntroductionThe differential diagnosis between Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD) is often challenging and detrimental to early and timely treatment. Co-current and overlapping symptoms contribute to erode differential diagnostic accuracy, based mainly on clinical assessment supported by standardized instruments and reports from parents and teachers. The microbiota was recently considered a valuable resource in the search for biological markers in neurodevelopmental disorders.ObjectivesOur objective was to examine the published literature in order to clarify the role of the microbiome as a possible differential biomarker between ASD and ADHD.MethodsFive hundred and sixteen articles were reviewed in order to contextualize the role of Gut- Brain Axis in neurodevelopment and neurodevelopmental disorders, the microbiome as a biomarker and ultimately to unravel microbiome abnormalities reported in patients diagnosed with ASD and/or ADHD.ResultsAlthough gut microbiome appears to be involved in the pathogenesis of ASD with several reports identifying changes in gut populations and functions, a “microbial signature” is still not reached. In ADHD patients, research confirms that the composition and predicted functions of gut microbiome are also altered, but identically controversial results were found.ConclusionsFuture studies are needed to confirm the relationship between the composition and function of the microbiome and the occurrence or presentation of each of the disorders. A specific signature of the microbiota could then constitute itself as a differential biomarker in ASD and ADHD.
Electrodermal activity – a promising biomarker for cardiovascular risk assessment in adolescent anorexia nervosa
Authors: Tonhajzerova I. , Ferencova N. , Ondrejka I. , Olexova L. Bona , Funakova D. , Hrtanek I. , Visnovcova Z. 
Published: February 2022

Introduction
Anorexia nervosa (AN) represents a severe mental disorder associated with cardiovascular complications leading to morbidity and mortality. Abnormal functioning of autonomic nervous system, particularly sympathetic nervous system, plays a crucial role in AN-linked psychopathology and cardiovascular diseases; however, the pathomechanisms are still unclear.ObjectivesThus, we studied sympathetic arousal in response to mental stress using conventional parameters, and for the first time by spectral analysis of electrodermal activity with aim to detect non-invasive biomarkers for cardiovascular risk assessment already in adolescent AN patients.MethodsTwenty-five AN girls were examined (14.8±0.4 yr.) and age/gender matched controls (15.1±0.3 years). Electrodermal activity (EDA) was continuously recorded at rest (5 min.) and in response to Go/NoGo test (5 min.). Evaluated parameters: skin conductance level (SCL) and spectral parameter of EDA in the sympathetic frequency band (EDASymp). EDA reactivity was calculated as percentual change (%) of SCL and EDASymp in response to stressor.ResultsThe AN group had significantly reduced SCL and EDASymp compared to controls during baseline (p=0.041, p=0.0001, respectively) and in response to Go/NoGo test (p=0.043, p=0.017, respectively). The EDASymp index reactivity was significantly lower in AN group compared to control (p=0.034).Conclusions
Our study revealed resting sympathetic underactivity associated with lower reactivity to mental stressor indexed by EDA parameters in adolescent AN patients. This altered pattern of sympathetic arousal could play important role as a pathomechanism leading to cardiovascular complications in AN. It seems that EDA indices represent potential non-invasive biomarkers to detect AN-linked cardiovascular risk already at adolescent age.Conflict of interestThis study was funded by the Slovak Scientific Grant Agency under grants VEGA 1/0044/18 and VEGA 1/0190/20 and Ministry of Health of the Slovak Republic under the project registration number 2018/20-UKMT-16.
The effect of vitamin C on sociability in a juvenile zebrafish pesticide-induced model of autism spectrum disorder
Authors: Robea M.A. , Ciobica A. , Strungaru S.-A. , Plavan G. , Nicoara M. , Solcan C. 
Published: February 2022

IntroductionAutism spectrum disorder (ASD) is a multi-factorial disease characterized by impairments in social interaction, communication and repetitive behaviors. The necessity of developing an adequate treatment for ASD is essential. There is an increase in clinical studies assessing the positive effects of vitamins in ASD children. Vitamin C (vit. C) is implicated in biosynthesis of neurotransmitters and in protein metabolism.ObjectivesThis study evaluated the possible effect of vit. C on zebrafish sociability after a single insecticide mixture administration as inductor for ASD.MethodsA single dose of insecticide mixture (600 μg L-1 fipronil and 600 μg L-1 pyriproxyfen) was administrated to zebrafish juvenile. Vit. C (25 μg L−1) was daily administrated during 14 days. A control group simulated the administration of insecticide mixture and vitamin. Each animal was tested in the experimental tank designed for the social interaction test. The trials were recorded and analysed using EthoVision XT 11 (NOLDUS, Netherlands). The locomotor activity parameters and the time spent next to the group were measured. Each trial had 4 minutes duration.Results
We have found no significant differences in the average levels between pre-treatment and treatment days (P< 0.05 ANOVA) regarding the locomotor activity parameters. Significant changes in sociability were observed for the group exposed to insecticide mixture and for vit. C group (P > 0.05 ANOVA). It was also found that 14 days vitamin administration can lead to sociability improvements after a single administration of mixture insecticide.ConclusionsThe results of the current study bring some positive insights for the future of ASD therapy.Conflict of interestThis work was co-funded by the European Social Fund, through Operational Programme Human Capital 2014-2020, project number POCU/380/6/13/123623, project title
Observing flaming or trolling online: Prevalence in russian youth and adolescents and relationship to tolerance and aggression
Authors: Soldatova G. , Chigarkova S. , Koshevaya A. , Rasskazova E. 
Published: February 2022

IntroductionCyberaggression including the most wide-spread variants of flaming (O’Sullivan, Flanagin, 2003; Voggeser et al., 2017) and trolling (Buckels et al., 2018) is affecting mental health of adolescents and youth although it could be (Kowalski, 2014; Wright, Wachs, 2020).ObjectivesThe aim was to study prevalence of flaming and trolling experience in Russian youth and adolescents and its relationship to general aggression and tolerance.Methods
525 adolescents 12-13 years old, 1029 adolescents 14-17 years old, 736 youth 18-30 years from 8 Federal regions in Russia appraised their experience of flaming or trolling online (as initiators, victims and observers) using vignettes. 1105 parents of adolescents appraised whether their children experienced flaming or trolling online. Then they filled Aggression Questionnaire (Buss, Perry, 1992) and Tolerance Index (Psychodiagnostics…, 2008).ResultsMore than one-half of adolescents (51-58% in 12-13 years old and 64% in 14-17 years old) and youth (45-69%) reported experience of flaming and trolling online, mostly as observers (32-65%). Parents accurately appraised flaming experience in their children but underestimated trolling experience (p<.05). Adolescents and youth observing flaming online report higher hostility, anger and physical aggression (F=17.8-28.3, p<.01, η²=.02) while lower social tolerance (F=4.27, p<.05, η²=.01). In adolescents observing trolling online these effects are stronger than in youth observing trolling online (interaction: F=5.68, p<.05, η²=.01).ConclusionsObserving trolling and flaming online is related to higher aggression and low tolerance in adolescents and youth and for adolescents the relationship is stronger. The reported study was funded by RFBR, project 20-013-00857.Conflict of interestThe reported study was funded by RFBR, project 20-013-00857.