bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highlights of the 2022 Vietnamese Society of Hypertension guidelines for the diagnosis and treatment of arterial hypertension
Authors: Van Minh Huynh , Van Huy Tran , Long Doan Pham Phuoc , Tien Hoang Anh 
Published: October 2022

AbstractHypertension is uncontrolled in over 50% hypertensive population in Vietnam which indicated a compelling need for new hypertension guidelines. The highlights were composed of three parts: the diagnosis of arterial hypertension, the recommendation of home blood pressure monitoring, and the treatment of hypertension. Our guideline applied flexibility based upon the “essential” and “optimal” concepts in the diagnosis and management of hypertensive patients according to the socio‐economic status of Vietnam. Hypertension is defined as an office systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg which is equivalent to a 24‐hr ambulatory blood pressure monitoring average of ≥130/80 mmHg or home blood pressure monitoring average of ≥135/85 mmHg. We established an integrated hypertensive diagnostic algorithm for adults with the optimal option by the role of out‐of‐office blood pressure measurement, especially home blood pressure monitoring, which is fully recommended in this guideline. The threshold and target of hypertension treatment were individualized in safety range and effective evidence‐based medicine. We also update for the management of resistant hypertension, hypertension in diabetic patients, hypertension with heart failure, and with other comorbidities. Vietnam has tried on the best strategy for improving the control of hypertension and recently received several achievements in the world, especially in the Asian region. Because the conditions for conducting our national data have not been fully conducted, we have to adapt from existing guidelines so there are still certain limitations that need to be supplemented and adjusted in the upcoming version.
Engrailed homeobox 1 transcriptional regulation of COL22A1 inhibits nasopharyngeal carcinoma cell senescence through the G1/S phase arrest
Authors: Huang Mao‐Ling , Luo Wen‐Long 
Published: October 2022

AbstractEN1 is well known as a transcription factor in other tumours, but its role in NPC is unclear. In this study, we first used bioinformatics to analyse GEO data to obtain the differentially expressed gene EN1, and subsequently verified that EN1 was highly expressed in nasopharyngeal carcinoma cells by tissue microarrays as well as cell lines. Further, we down‐regulated the expression of EN1 in cells for RNA sequencing. The analysis of sequencing results using KEGG and GO revealed significant changes in cell proliferation and cycle function after downregulation of EN1. Meanwhile, we found that cells underwent senescence after inhibition of EN1 under electron microscopy and the SA‐β‐gal assays. Based on the sequencing results, we verified that EN1 can promote the proliferation and cycle of NPC cells in cell function experiments and animal experiments. To investigate how EN1 affects cell senescence, we found that EN1 transcriptional regulation of COL22A1 regulated cell proliferation and cycle via CDK4/6‐cyclin D1‐Rb signalling pathway by dual luciferase reporter, Immunoblotting and rescue experiment. Accordingly, we uncovered that EN1 could serve as a target for the regulation of senescence in NPC.
Pressure for rapid and accurate mate recognition promotes avian‐perceived plumage sexual dichromatism in true thrushes (genus: Turdus)
Authors: Luro Alec B. , Hauber Mark E. 
Published: October 2022

AbstractEcological conditions limiting the time to find a compatible mate or increasing the difficulty in doing so likely promote the evolution of traits used for species and mate recognition. In addition to interspecific character displacement signalling species identity, intraspecific traits that signal an individual's sex and breeding status reduce the challenge of identifying a compatible conspecific mate and should be more common in migratory rather than sedentary species, species with shorter breeding seasons and species breeding under high sympatry with many closely related heterospecifics. Here, we tested this recognition hypothesis for promoting plumage sexual dichromatism in the true thrushes (Turdus spp.), a large and diverse genus of passerine birds. We used receptor‐noise limited models of avian vision to quantify avian‐perceived chromatic and achromatic visual contrasts between male and female plumage patches and tested the influence of breeding season length, spatial distribution and sympatry with other Turdus species on plumage dichromatism. As predicted, we found that (1) true thrush species with migratory behaviour have greater plumage sexual dichromatism than non‐migratory species, (2) species with longer breeding seasons have less plumage sexual dichromatism, and (3) greater numbers of Turdus thrush species breeding in sympatry is associated with more plumage sexual dichromatism. These results suggest that social recognition systems, including species and mate recognition, play a prominent role in the evolution of plumage sexual dichromatism in true thrushes.
Isotopic niche alteration of a predator fish in a dammed Amazonian black water river
Authors: Aguiar‐Santos Jamerson , deHart Pieter A. P. , Forsberg Bruce R. , Freitas Carlos E. C. 
Published: October 2022

AbstractAlthough many upstream effects of a dam on the trophic ecology of fish have been reported, little is known about their downstream effects on the isotopic niche of Amazonian predator fish. The authors used stable isotope analysis of δ13C and δ15N to determine the downstream effects of damming of the Uatumã River on the niche width, carbon energy sources and trophic position of peacock bass Cichla temensis comparing with a free‐flowing river in the Amazon basin, Brazil, during the peak flood and early falling water period of 2020. They found that the C. temensis population of the undammed river had a smaller niche width than the C. temensis population of the dammed river, despite the greater number of prey trophic levels utilized and the higher trophic position of C. temensis individuals. The results demonstrate that in both rivers there is a gradual shift in the contribution of prey fish sources to the diet of C. temensis throughout its growth, even among adult individuals. They conclude that the isotopic niche of C. temensis was altered by damming during the period of late high water to early low water in the Uatumã River.
Probiotic coffee ice cream as an innovative functional dairy food
Authors: Shazly Ahmed B. , Fouad Mohamed T. , Elaaser Mostafa , Sayed Rehab S. , Abd El‐Aziz Mahmoud 
Published: October 2022

AbstractThe use of concentrated coffee extract (CCE) with probiotic bacteria in the production of ice cream was evaluated as an innovative functional dairy food. The most prevalent phenolic compounds and B‐complex vitamins in CCE were chlorogenic acid and folic acid, with 7.39 and 4.67 mg/ml, respectively. CCF showed strong antibacterial activity against both gram‐positive and gram‐negative bacteria as well as fungi. Ice cream formulated with 3% CCE showed higher overrun (41.76%), fat destabilization (15.14%), and melting rate (1.19 g/min). The addition of probiotic bacteria Bifidobacterium breve Bb‐12 and Lactobacillus plantarum increased the mixture's viscosity, overrun and melting rate. CCE‐containing ice creams exhibited significant antioxidant activity against the DPPH and ABTS radicals, with the increase being proportional to the CCE content. In comparison to ice cream containing 5% CCE, ice cream containing 3% CCE, with and without probiotic bacteria, had a favorable brown color, a smoother texture, less bitterness, and the desired coffee flavor. It can be concluded that 3% CCE with probiotic bacteria can be used to produce a functional ice cream with the desired coffee flavor and rich in natural bioactive compounds such as phenols and vitamins.Novelty impact statement

Probiotic coffee ice cream is a functional dairy food that contains necessary nutrients and is rich in phenolic compounds that display strong antioxidant and antimicrobial activity in addition to being supported by probiotic bacteria.

Probiotic coffee ice cream is a distinct type of ice cream with the desired coffee flavor for most consumers and it improves the mental state and helps burn calories.

In addition to its health benefits, the use of probiotic bacteria can improve the mixture's viscosity and increase the overrun of the resulting ice cream.
Psychological resilience in older adults with type 2 diabetes from the Look AHEAD Trial
Authors: Olson KayLoni L. , Howard Marjorie , McCaffery Jeanne M. , Dutton Gareth R. , Espeland Mark A. , Simpson Felicia R. , Johnson Karen C. , Munshi Medha , Wadden Thomas A. , Wing Rena R. ,   the Look AHEAD Research Group
Published: October 2022

AbstractBackgroundThere is growing interest in identifying factors associated with healthy aging. This cross‐sectional study evaluated associations of psychological resilience with factors associated with aging in older adults with type 2 diabetes mellitus (T2DM).MethodsParticipants were 3199 adults (72.2 ± 6.2 years of age, 61% female, 61% White, body mass index [BMI] = 34.2 ± 8.2 kg/m2) with T2DM enrolled in Look AHEAD (a multi‐site randomized clinical trial comparing an intensive lifestyle intervention for weight loss to diabetes education and support). Participants were followed observationally after the 10‐year intervention was discontinued. The following items were assessed approximately 14.4 years post‐randomization in a cross‐sectional analysis: Brief Resilience Scale; overnight hospitalizations in past year; physical functioning measured objectively (gait speed, grip strength) and via self‐report (Pepper Assessment Tool for Disability; physical quality of life [QOL; SF‐36]); a measure of phenotypic frailty based on having ≥3 of unintentional weight loss, low energy, slow gait, reduced grip strength, and physical inactivity. Depressive symptoms (PHQ‐9) and mental QOL (SF‐36) were also measured. Logistic/linear/multinomial regression was used to evaluate the association of variables with resilience adjusted for age, race/ethnicity, and gender.ResultsGreater psychological resilience was associated with lower BMI, fewer hospitalizations, better physical functioning (i.e., lower self‐reported disability, better physical QOL, faster gait speed, greater grip strength, lower likelihood of frailty), fewer depressive symptoms, and greater mental QOL (all p < 0.05). Psychological resilience moderated the relationship of number of hospitalizations in the past year with self‐reported disability and grip strength.ConclusionsPsychological resilience is associated with better physical function and QOL among older adults. Results should be interpreted cautiously given cross‐sectional nature of analyses. Exploring the clinical benefits of resilience is consistent with efforts to shift the narrative on aging beyond “loss and decline” to highlight opportunities to facilitate healthy aging.
Development and validation of a prediction model for persistent functional impairment among older ICU survivors
Authors: Ferrante Lauren E. , Murphy Terrence E. , Leo‐Summers Linda S. , O'Leary John R. , Vander Wyk Brent , Pisani Margaret A. , Gill Thomas M. 
Published: October 2022

AbstractBackgroundCritical illness often leads to persistent functional impairment among older Intensive Care Unit (ICU) survivors. Identification of high‐risk survivors prior to discharge from their ICU hospitalization can facilitate targeting for restorative interventions after discharge, potentially improving the likelihood of functional recovery. Our objective was to develop and validate a prediction model for persistent functional impairment among older adults in the year after an ICU hospitalization.MethodsThe analytic sample included community‐living participants enrolled in the National Health and Aging Trends Study 2011 cohort who survived an ICU hospitalization through December 2017 and had a follow‐up interview within 1 year. Persistent functional impairment was defined as failure to recover to the pre‐ICU level of function within 12 months of discharge from an ICU hospitalization. We used Bayesian model averaging to identify the final predictors from a comprehensive set of 17 factors. Discrimination and calibration were assessed using area‐under‐the‐curve (AUC) and calibration plots.ResultsThe development cohort included 456 ICU admissions (2,654,685 survey‐weighted admissions) and the validation cohort included 227 ICU admissions (1,350,082 survey‐weighted admissions). In the development cohort, the median age was 81.0 years (interquartile range [IQR] 76.0, 86.0) and 231 (50.7%) participants were women; demographic characteristics were comparable in the validation cohort. The rates of persistent functional impairment were 49.3% (development) and 50.2% (validation). The final model included age, pre‐ICU disability, probable dementia, frailty, prior hospitalizations, vision impairment, depressive symptoms, and hospital length of stay. The model demonstrated good discrimination (AUC 71%, 95% confidence interval [CI] 0.66–0.76) and good calibration. When applied to the validation cohort, the model demonstrated comparable discrimination (AUC 72%, 95% CI 0.66–0.78) and good calibration.ConclusionsApplication of the model prior to discharge from an ICU hospitalization may identify older adults at the highest risk of persistent functional impairment in the subsequent year, thereby facilitating targeted interventions and follow‐up.
The modified inframammary fold suture method and its clinical significance in primary augmentation mammoplasty
Authors: Qin Feng , Zeng Ang , Yu Nanze , Dong Ruijia , Long Fei , Xia Zenan , Zhang Wenchao , Long Xiao , Wang Xiaojun 
Published: October 2022

AbstractBackgroundThe inframammary approach is one of the most commonly used incisions in breast augmentation. There are many suture methods for inframammary incisions; however, no one method has proven optimal. We modified the traditional three‐layer suture method according to the inframammary fold (IMF) cadaver dissection results. This study aims to investigate whether using a modified suture method can improve postoperative outcomes.MethodsCadaver dissections were performed in order to clarify the anatomy of the IMF. From June 2013 to December 2017, a retrospective study of primary breast augmentation patients subjected to the inframammary approach was conducted. Patients were divided into two cohorts: the traditional suture method and the modified suture method. The patient's demographics, specifics of breast augmentation procedures, complications, and scar assessment were analyzed. Univariate and multivariable analyses were used to determine differences between the two cohorts.ResultsOne hundred eighty‐four patients were included: 75 patients were subjected to the traditional suture method, and 109 patients were subjected to the modified suture method. Wound‐related adverse events (p = 0.026) and IMF‐indented scarring (p = 0.014) were significantly different between the two groups. Multivariable analysis showed that the suture method was the most influential factor related to IMF‐indented scarring (OR = 16.9), followed by BMI (OR = 2.9).ConclusionsWe defined a new suture method for the inframammary incision in primary breast augmentation. This modified suture method reduces the occurrence of wound‐related adverse events and IMF‐indented scarring.
A nationwide study of obstetric management and outcomes in premature rupture of membrane at term: Report from the Perinatology Committee, Japan Society of Obstetrics and Gynecology, 2017–2018
Authors: Oda Tomoaki , Mitsuda Nobuaki , Miyakoshi Kei , Makino Shintaro , Ishii Keisuke , Kurasawa Kentaro , Kubo Takahiko , Shimoya Koichiro , Ikeda Tomoaki , Kanayama Naohiro 
Published: October 2022

AbstractAimThis nationwide study aimed to investigate the practical management of term premature rupture of membrane (PROM) and its relationship with maternal and neonatal outcomes.MethodsWe conducted a questionnaire survey of 415 facilities participating in the Japan Perinatal Registry Network of the Japan Society of Obstetrics and Gynecology in 2016. The patients were women expecting vaginal birth after PROM at term without clinical chorioamnionitis. We classified the facilities into three groups based on duration of the expectant management after PROM (within 24, 24, and 48 h). Furthermore, we analyzed the association between perinatal outcomes and management protocol using the Japan Perinatal Registry Network Database 2016.ResultsOf 415 facilities, 346 (83.4%) completed and returned the survey. Among 231 facilities with management protocols, an interval of 3 days from PROM to delivery was acceptable in 167 facilities (72.3%). One hundred forty‐nine facilities (64.5%) responded that they did not perform mechanical cervical dilation, and 90 (39.0%) used oxytocin as a uterotonic irrespective of cervical maturation. The number of hospitals that had a policy to administer antibiotics to Group B streptococcus‐positive patients was 211 (91.3%). Neonatal outcomes at birth and the frequency of cesarean section and postpartum fever did not differ among the three groups.ConclusionsMost facilities in the Japan Perinatal Registry Network managed women at term to delivery within 3 days after PROM with attention to bacterial infection. Expectant management up to 48 h after PROM did not increase the risk of postpartum fever, compared to labor induction immediately after PROM.
Uterine‐sparing laparoscopic lateral suspension in the treatment of pelvic organ prolapse
Authors: Kumbasar Serkan , Salman Suleyman , Sogut Ozlem , Ketenci Gencer Fatma , Bacak Havva B. , Tezcan Ayse D. , Timur Gözde Y. 
Published: October 2022

AbstractAimApical prolapse is an important component of pelvic organ prolapse. The aim of our study was to investigate the effectiveness of laparoscopic lateral suspension (LLS) surgery, which we performed while sparing the uterus.MethodsLLS surgery was performed on 62 patients due to apical prolapse, preserving their uterus. The patients' pelvic organ prolapse quantification system (POP‐Q) points and sexual function using pelvic organ prolapse/urinary incontinence sexual function questionnaire (PISQ‐12) prior to and 12 months following the surgery were compared, and the results were evaluated.ResultsThe POP‐Q points and PISQ‐12 scores evaluating sexual function of the patients who underwent LLS were significantly improved compared to pre‐operation values (p ˂ 0.001). No intraoperative complications were observed in the patients. Recurrence was observed in 6 (9.6%) of 62 total cases in post‐operative follow‐up. Apical prolapse was seen in two patients (3.2%), and anterior vaginal wall recurrence was observed in one patient (1.6%). Posterior vaginal wall recurrence was seen in three patients (4.8%). Pelvic pain complications were observed in four patients (6.4%) in the postoperative follow‐up. Mesh erosion was not observed in any of the cases. It was observed that 5 (38%) of 13 patients with stress urinary incontinence (SUI) had improved SUI complaints after surgery. The mean operation time was 66.3 ± 12.3 min.ConclusionLLS is an effective and safe method for patients with apical prolapse who want to preserve their uterus. LLS can be applied as an alternative to the sacrocolpopexy procedure, which has risks such as potentially serious neurological and life‐threatening vascular injury in the sacral region.
Falling treatment uptake in the hepatitis C care cascade is a growing threat to achieving elimination
Authors: Bryce Kathleen , Smith Colette , Rodger Alison , Macdonald Douglas 
Published: October 2022

AbstractMost high‐income countries are not on track to achieve the World Health Organization hepatitis C elimination targets. As elimination programmes assess growing proportions of patients in community‐based pathways, rates of treatment uptake may fall. We aimed to identify factors associated with DAA treatment uptake and measure changes in their prevalence over time. We performed a time‐to‐treatment analysis on 2728 patients approved for hepatitis C Direct‐Acting Antiviral treatment in the North Central London region between January 2016 and October 2019. We investigated the association between treatment uptake and factors including assessment/treatment setting (hospital, drug service or prison), patient age, gender, injection drug use, harmful alcohol use, cirrhosis status and previous treatment. The likelihood of treatment uptake was reduced by three independent risk factors. These included assessment setting: prison‐based or drug‐service pathways (aHR 0.29 or 0.81 vs. hospital outpatient pathway, 95% CI 0.21–0.40 and 0.70–0.94 respectively, p < .001); being UK‐born (aHR 0.89 vs. non‐UK born, 0.82–0.98, p = .01); and history of harmful alcohol use (aHR 0.84 vs. no history, 0.72–0.99, p = .04). The average number of these risk factors for not starting treatment per patient increased over time (R2 = 0.66 p < .001). Independent of these, there was an additional 5% reduction in rate of treatment initiation in each successive year of the programme (aHR 0.95, 0.91–0.99, p = .02). In conclusion, disengagement from care before treatment uptake was found to be a growing threat to elimination. Despite provision of community‐based test‐to‐cure pathways, there are persistent barriers to treatment uptake and these are increasing over time.
Implementation of a re‐linkage to care strategy in patients with chronic hepatitis C who were lost to follow‐up in Latin America
Authors: Mendizabal Manuel , Thompson Marcos , Gonzalez‐Ballerga Esteban , Anders Margarita , Castro‐Narro Graciela E. , Pessoa Mario G. , Cheinquer Hugo , Mezzano Gabriel , Palazzo Ana , Ridruejo Ezequiel , Descalzi Valeria , Velarde‐Ruiz Velasco Jose A. , Marciano Sebastian , Muñoz Linda , Schinoni Maria I. , Poniachik Jaime , Perazzo Rosalía , Cerda Eira , Fuster Francisco , Varon Adriana , Ruiz García Sandro , Soza Alejandro , Cabrera Cecilia , Gomez‐Aldana Andres J. , Beltrán Flor de María , Gerona Solange , Cocozzella Daniel , Bessone Fernando , Hernández Nelia , Alonso Cristina , Ferreiro Melina , Antinucci Florencia , Torre Aldo , Moutinho Bruna D. , Coelho Borges Silvia , Gomez Fernando , Murga Maria Dolores , Piñero Federico , Sotera Gisela F. , Ocampo Jhonier A. , Cortés Mollinedo Valeria A. , Simian Daniela , Silva Marcelo O. 
Published: October 2022

AbstractTo achieve WHO's goal of eliminating hepatitis C virus (HCV), innovative strategies must be designed to diagnose and treat more patients. Therefore, we aimed to describe an implementation strategy to identify patients with HCV who were lost to follow‐up (LTFU) and offer them re‐linkage to HCV care. We conducted an implementation study utilizing a strategy to contact patients with HCV who were not under regular follow‐up in 13 countries from Latin America. Patients with HCV were identified by the international classification of diseases (ICD‐9/10) or equivalent. Medical records were then reviewed to confirm the diagnosis of chronic HCV infection defined by anti‐HCV+ and detectable HCV‐RNA. Identified patients who were not under follow‐up by a liver specialist were contacted by telephone or email, and offered a medical reevaluation. A total of 10,364 patients were classified to have HCV. After reviewing their medical charts, 1349 (13%) had undetectable HCV‐RNA or were wrongly coded. Overall, 9015 (86.9%) individuals were identified with chronic HCV infection. A total of 5096 (56.5%) patients were under routine HCV care and 3919 (43.5%) had been LTFU. We were able to contact 1617 (41.3%) of the 3919 patients who were LTFU at the primary medical institution, of which 427 (26.4%) were cured at a different institutions or were dead. Of the remaining patients, 906 (76.1%) were candidates for retrieval. In our cohort, about one out of four patients with chronic HCV who were LTFU were candidates to receive treatment. This strategy has the potential to be effective, accessible and significantly impacts on the HCV care cascade.