bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular typing and drug resistance analysis of carbapenem-resistant Klebsiella pneumoniae from paediatric patients in China
Authors: Zhang Xian , Xue Jian , Shen Mei-Jing , An Wen-Hong , Chen Ze-Qiong , Wu Kai-Feng 
Published: November 2022

Introduction: There are few studies on paediatric carbapenem-resistant Klebsiella pneumoniae (CRKP) in China. The present study investigated the molecular epidemiological and drug resistance characteristics of CRKP from paediatric patients in China to provide a reference for the prevention and control of CRKP infection.
Methodology: In total, 20 nonrepetitive clinical CRKP isolates were collected between February 2019 and February 2020 in a tertiary hospital in China. Strain identification and drug susceptibility testing were carried out using the VITEK® 2 Compact Bacterial Identification and Monitoring System. Sequence typing, phylogenetic relationships, and antibiotic resistance-associated genes were analysed by whole genome sequencing (WGS).
Results: sequence typing (MLST) and Core genome multilocus sequence typing (cgMLST) analysis revealed the most frequently represented were ST2407-CT3536 (30%), ST76-CT5893 (25%), and ST309-CT7864 (25%). All 20 CRKP isolates were divided into three clusters. All isolates were highly resistant to a variety of β-lactams and were highly susceptible to quinolones, aminoglycosides, and sulphonamides. All isolates mainly carried the carbapenem resistance genes blaNDM-1 and blaKPC-2, among which 10 isolates carried both blaNDM-1 and blaKPC-2 simultaneously.
Conclusions: Sequence typing, phylogenetic relationships, and antibiotic resistance genes can be determined using WGS technology. This can guide CRKP infection control and clinical treatment for paediatric patients.
ITS-RFLP optimization for dermatophyte identification from clinical sources in Alagoas (Brazil) versus phenotypic methods
Authors: Villanueva da Fonseca Luisa Andrea , Santos Araújo Maria Anilda , Wanderlei Silva Denise Maria , De Albuquerque Maranhão Fernanda Cristina 
Published: November 2022

Introduction: Dermatophytoses are superficial mycoses, and the identification of their etiological agents is routinely performed by culture and microscopic features, which is time-consuming and relies on personnel expertise. Molecular approaches have been developed to provide faster and reliable results; therefore, this study aimed to identify dermatophytes isolated from Alagoas state patients, employing phenotypical and molecular methods.
Methodology: Clinical samples for morphological identification were collected from private and public laboratories and cultivated on Sabouraud dextrose agar. DNA extraction was followed by ITS amplicon analysis after restriction enzyme digestion DdeI (ITS-RFLP).
Results: Out of fourteen representative strains, ITS-RFLP with DdeI efficiently identified Microsporum canis, Nannizzia gypsea, and Trichophyton rubrum, while species of the complex T. tonsurans/T. mentagrophytes presented the same restriction pattern. After genotyping, 2 T. tonsurans and 1 Microsporum sp. strain were reclassified as T. rubrum.
Conclusions: RFLP of ITS-region followed by DdeI digestion produced faster and relatively reliable results than classic methods; however, this method has not been as efficient for closely related dermatophytes cryptic species.
L’innovation comme compétence entrepreneuriale pour des étudiants en gestion agricole : pertinence et difficultés
Authors: Rivenet Nathalie , Philippart Pascal , Dokou Gérard Akrikpan Kokou 
Published: November 2022

À l’aune des enjeux à relever pour l’agriculture, l’innovation est cruciale. Il est donc pertinent de préparer les futurs agriculteurs à innover. Par ailleurs, le développement de la compétence innovation chez les étudiants a fait l’objet de peu de recherche. Cet article porte sur l’évaluation de l’impact de la participation à un concours de création d’entreprise sur la compétence innovation. Il repose sur une étude quantitative et qualitative de 81 entretiens. Les étudiants ont interprété les résultats de leur score innovation et son évolution, calculés à partir du test MACE (Motivation, Aptitudes et Comportement Entrepreneurial). Nos résultats montrent un développement de la compétence innovation suite à l’expérience entrepreneuriale, provenant de facteurs externes, propres à l’étudiant et liés à la pédagogie. Pour ces derniers, l’essai est déterminant mais aussi le sens et l’affectif. Codes JEL : O31
Justice et auto-défense sans l’État dans le Rojava kurde
Authors: Dirik Dilar 
Published: November 2022

L’article documente un exemple particulièrement inspirant d’une expérimentation de la justice transformatrice à l’échelle d’une « nation sans État » – celle du Rojava kurde, où une révolution communaliste est toujours en cours. Cette étude sociologique décrit les pratiques de justice locale, appuyée (côté préventif) sur une éducation collective à l’auto-défense et (côté judiciaire) sur des pratiques de responsabilisation communautaire. On y voit que le rejet de la police et des prisons d’État ne signifie nullement une absence d’institutionnalisation, mais que d’autres institutions de justice (transformatrice) sont possibles.
Semences de liberté
Authors: Gumbs Alexis Pauline , Bigé Emma , Noûs Camille 
Published: November 2022

Ce texte passe en revue les caractéristiques principales d’une expérience de jardins ouvriers menée à Durham, en Caroline du Nord pour lutter contre les violences sexuelles et sexistes. Le jardin, l’acte de jardiner sont envisagés comme des techniques de justice transformatrice : se rassembler, entrer en contact les unes avec les autres, cultiver de quoi se nourrir, sentir la terre et les histoires de violence qui la précèdent, se donner les moyens d’y faire pousser autres choses. Toutes ces pratiques interrelient l’histoire, la communauté et les conditions matérielles d’existence pour faire exister la justice sous la forme de plantes qui poussent, là même où, selon les mots d’Audre Lorde, « nous n’étions pas censées survivre ».
Pour une pharmacodynamie des techniques
Authors: Beaubois Vincent 
Published: November 2022

Nous proposons de lire ensemble les textes de Félix Guattari portant sur la production d’une « subjectivité capitalistique » avec ceux qu’il consacre à la question des « drogues » afin d’interroger le sens de nos couplages technologiques industriels. Cette conjonction dessine les linéaments d’une philosophie de la technique originale centrée sur l’« expérimentation risquée » que nous qualifierons de « pharmacodynamie » des techniques, par analogie avec les pratiques des « personnes utilisatrices de drogues ».
L’effet-guattari au prisme des quartiers populaires
Authors: Rabaté Ulysse 
Published: November 2022

Les mobilisations qui émergent depuis plusieurs décennies dans les quartiers populaires français se font à distance des structures établies d’énonciation de la politique. Ce que nous pourrions considérer avec le vocabulaire de Guattari comme un mouvement de déterritorialisation s’est réalisé dans le cadre de rapports de pouvoirs spécifiques, invisibilisés par la grammaire des conflits politiques. Identifier les lignes de fuite élaborées dans la pratique par des mobilisations souvent considérées hors-radars (« ce n’est pas de la politique »), impose de « sortir de la langue » et contourner les modes de signification qui sont aussi modes de confiscation. Les outils légués par Félix Guattari nous aident à affronter une question qui demeure : réside-t-il dans cette brèche creusée en conflit avec les « données » de la domination, un mouvement irrépressible vers la transformation des rapports sociaux du capitalisme, et donc une cohérence des subjectivations et des pratiques en direction de cet objectif ?
Modes coopératifs insurgés
Authors: Guatelli Igor , Wisnik Guilherme 
Published: November 2022

Coopération, co-opérations, sont des expressions qui énoncent le co, le cum , l’être ensemble comme condition de l’apparition du territoire de partage et d’une autre démocratie. Au début du millénaire, une transformation est devenue perceptible dans les villes du Brésil : un désir nouveau pour l’espace public et commun. Ce désir est apparu sous forme d’une myriade de mouvements activistes d’occupation et d’appropriation des espaces publics. Nous nous référons à des mouvements horizontaux, non hiérarchisés et auto-organisés de la société civile, qui ont acquis une grande importance politique tels que les mouvements « Ocupe Estelita » à Recife, « Praia da Estação » à Belo Horizonte, et « A Batata Precisa de Você » à São Paulo.
Équipements, agencements, diagrammes
Authors: Citton Yves 
Published: November 2022

Cet article relit de près certains passages de l’ouvrage de Félix Guattari publié de façon posthume sous le titre Lignes de fuite , pour en tirer une théorie des infrastructures articulées en termes d’équipements et de déséquipement. Le contraste entre « agencements » et « équipements » permet de mieux comprendre les enjeux de ce qui relève aujourd’hui d’une écologie du démantèlement (Bonnet, Landivar, Monnin), ainsi que le besoin de nous doter de nouvelles formes de cartographies diagrammatiques (Davila).
Exposition précoce à la sexualité et croyances addictives dans l’addiction sexuelle : une étude qualitative exploratoire
Authors: Hegbe Komlan Gnimavo , Réveillère Christian , Barrault Servane 
Published: November 2022

La littérature scientifique suggère le rôle des vulnérabilités cognitivo-émotionnelles et des systèmes de croyances dans les conduites addictives en général. Cependant, aucune étude, à notre connaissance, n’a pris en compte le rôle des croyances dysfonctionnelles particulières à l’addiction sexuelle. De plus, l’exposition précoce à la sexualité (qu’il s’agisse de la confrontation précoce aux contenus sexuels explicites ou d’abus sexuels dans l’enfance) semble jouer un rôle non négligeable dans le développement de cette addiction. L’objectif de la présente étude est d’explorer cette thématique. Sept sujets, issus d’un échantillon principal de 398 participants recrutés en ligne, ont participé à un entretien de recherche. Tous les entretiens ont été enregistrés et entièrement retranscrits. Une analyse lexicale quantitative a été réalisée à l’aide du logiciel Iramuteq. Quatre classes de mots ont été mises en évidence, englobant 76,61 % de l’ensemble du corpus. Les principaux thèmes abordés sont l’exposition précoce à la sexualité, les croyances anticipatoires, soulageantes et permissives, ainsi que le vécu de l’addiction sexuelle. Nos résultats montrent la présence de ces croyances addictives chez nos sujets et la place de la confrontation précoce avec la sexualité dans le développement de leur addiction. En dépit de la taille faible de notre groupe de sujets, cette étude exploratoire permet une meilleure compréhension de l’addiction sexuelle et ouvre de nombreuses perspectives cliniques et de recherche.
Transition to Pandemic: Reality Shock and Role Development for the Novice Nurse
Authors: Glynn Donna M. , Colleran Cook Michelle , Cullen Mary Lou , Landers Elizabeth R. 
Published: November 2022

Background
The challenges related to the transition to professional nursing practice for the novice nurse have been well documented. In 2020, the transition to professional nursing was complicated by COVID-19. This research assimilated important qualitative perceptions related to the reasons novice nurses sought professional nursing practice and the impact of the pandemic on the decision to become a nurse, and identified the novice nurses' concerns related to COVID-19 and direct patient care.

Method
A qualitative survey was completed by recent BSN graduates. Data were analyzed using content analysis of the open-ended questions.

Results
New graduate RNs identified the following themes: helping and caring for others; being inspired by practicing nurses; apprehension; validation of professional choice; dangerous conditions; and underprepared to care for patients with COVID-19.

Conclusion

Nurse leaders should be cognizant that the transition experience of new nurses who began their practice during the pandemic may be more complex than that of previous new nurses. The information from this study presents an opportunity for the staff of health care institutions to be mindful of these factors as they mentor and support these much-needed new nurses.

[
J Contin Educ Nurs
. 2022;53(12):557–564.]
Unilateral Acute Parotitis
Authors: Sharma Sushil , Mahajan Vikas , Gupta Ravinder 
Published: November 2022

Background:
Severe acute respiratory virus coronavirus-2 infection or coronavirus disease (COVID) is categorized into acute illness and late multiinflammatory syndrome in children (MISC). This has recently been challenged with recognition of presentations with mucocutaneous-enteric symptoms that display considerable overlap between the two. We recognized a similar overlap of manifestations when encountered the three cases of fever associated with unilateral parotitis.

Clinical Description:
The three patients were of different age groups ranging from 2 months to 7 years of age, all of whom presented with fever, unilateral swelling of face and neck consistent with the region of the parotid gland, and absence of other localizing symptoms or abnormalities on examination. All of them were positive for COVID antibodies, had negative COVID real-time polymerase chain reaction test, did not satisfy the diagnostic criteria of MISC, but had raised inflammatory markers. Since the workup for other common causes of acute parotitis was negative, a clinical diagnosis of post-COVID immune-mediated acute parotitis was kept.

Management:
All the three patients were managed with systemic steroids (oral or parenteral) and showed complete resolution of symptoms and normalization of laboratory parameters within a few days, a therapeutic response in alignment with an immune-mediated phenomenon.

Conclusion:
Acute unilateral parotitis with pyrexia may be a hitherto unreported late post-COVID manifestation that is immune mediated and shows an excellent therapeutic response to a short course of steroids.
Cutaneous Tuberculosis
Authors: Mahajan Akanksha , Garg Taru , Agarwal Kiran , Singh Varinder 
Published: November 2022

Background:
Cutaneous tuberculosis (TB) is a rare disease seen by the pediatrician on an outpatient basis. It has a varied presentation and is classified on the basis of the source of infection and host's immune response to mycobacteria. Lupus vulgaris (LV) is a paucibacillary manifestation of cutaneous TB. It can mimic other infectious skin diseases such as TB verrucosa cutis and chromoblastomycosis.

Clinical Description:
We hereby present a case report of an adolescent female with a serpiginous, nodular, and warty hyperpigmented skin lesion over her buttock. The lesion had started following incidental injury 7 years back as a papule and continued to expand despite multiple medications.

Management:
A skin biopsy was done which was suggestive of cutaneous TB, but the absence of systemic features confounded the diagnostic type. She was finally diagnosed as having LV after a detailed review with a dermatologist and pathologist. The patient responded well to antitubercular treatment.

Conclusion:
Although cutaneous tuberculosis is well described, it is often not recognized by the primary care physician. Diagnostic dilemmas may arise due to clinical-histopathological mismatch.
Wilke's Syndrome
Authors: Arora Nikhil , Kaur Gurmeet , Kaul Varun , Singh Man 
Published: November 2022

Background:
Superior mesenteric artery (SMA) syndrome or Wilke's syndrome is a rare, atypical cause of upper gastrointestinal tract obstruction. It occurs due to acute angulation between SMA and aorta causing compression of the third part of the duodenum inbetween them leading to proximal intestinal obstruction.

Clinical Description:
SMA syndrome occurs mostly in patients who have significant weight loss. It occurs mostly due to the loss of the retroperitoneal fat pad, which serves as a cushion for the duodenum protecting it from compression between the two arteries. Causes include prolonged supine bed rest, spine surgery, an unusual high insertion of ligament of Treitz, other causes leading to weight loss, and congenital anatomical defects. Symptoms include weight loss, bilious vomiting, pain abdomen, postprandial nausea, early satiety, and anorexia. We report a 14-year-old female, a known case of pulmonary tuberculosis, who developed pneumothorax followed by acute gastric dilatation superadded with septicemia and upper gastrointestinal tract obstructive symptoms during the hospital course.

Management:
Detailed history and radio imaging such as barium studies or contrast-enhanced computerized tomography abdomen are required for diagnosis. Treatment includes conservative management such as gastric decompression, maintenance of electrolytes, nutritional rehabilitation via nasojejunal feeding, orally or parenterally. Treatment aims to restore the mesenteric fat pad to increases the angle between the two arteries. If it fails, surgery needs to be planned wherein duodenojejunostomy can be performed.

Conclusion:
An increased index of suspicion should be kept for this rare syndrome in children, especially in cases associated with significant weight loss. This may lead to timely diagnosis and saving a precious life.
An Unusual Case of Tongue Entrapment in a Plastic Water Bottle
Authors: Ahmad Shafaat , Goel Prakhar , Meher Ravi , Wadhwa Vikram 
Published: November 2022

Background:
Foreign bodies inside the oral cavity are commonly encountered among children. One peculiar occurrence is when the tongue gets entrapped in foreign bodies such as bottles. This happens as children often insert their tongues into the bottle and apply oral suction to ingest the last few drops from the bottle. There is a paucity of data in Indian literature and no recommended guidelines for the management of such cases.

Clinical Description:
The patient, a 12-year-old boy had a history of inability to remove a plastic water bottle sipper from around the tongue while swallowing water quickly. He was initially asymptomatic and then he started developing progressive pain and swelling on the anterior part of the tongue. On examination, the plastic sipper was constricting the tongue circumferentially and the patient felt a sharp pain on maneuvering the bottle. Minimal discoloration of the anterior part of the tongue had set in 1 h after the presentation.

Management:
Lubrication with 2% lignocaine jelly and ice packs circumferentially followed by attempts of gentle traction and manipulation to remove the foreign body were unsuccessful. Consequently, the patient was shifted to the emergency operation theater where the patient was sedated with intravenous (IV) ketamine and midazolam after securing a nasopharyngeal airway with 100% preoxygenation. An orthopedic bone cutter was used, and a radial cut was given on the impacted end of the bottle, and the constricted part was removed as pressure on the tongue was released, followed by 100% oxygenation with bag and mask ventilation.

Conclusion:
Immediate intervention in cases of the entrapped tongue can prevent grave consequences such as airway compromise and tongue ischemia and necrosis. Mechanical removal can be done safely using heavy scissors or orthopedic bone under IV sedation after securing the airway in collaboration with the anesthesia team.
Thyroglobulin as an Evolving Biomarker of Iodine Reserve in Thyroid Dysfunction Assessment in Pregnancy
Authors: Gbaa Terry Terfa 
Published: November 2022

Background:
Despite the use of routine thyroid function tests, thyroid dysfunction is often missed in pregnant women, who may have fluctuating iodine reserves and this may be associated with an increased risk of adverse maternal and fetal outcomes due to thyroid dysfunction. Therefore, thyroglobulin (Tg) as a marker of iodine reserve may be added to improve the diagnostic value of the thyroid testing panel.

Materials and Methods:
This study was a multicenter descriptive cross-sectional study with 501 healthy pregnant women, carried out over 9 months, in which blood and urine (spot) specimens were collected and analysed for serum thyroid-stimulating hormone, free thyroxine, free triiodothyronine, and Tg using enzyme-linked immunosorbent assay, and urinary iodine concentration by modified Sandell–Kolthoff reaction.

Results:
The prevalence of thyroid dysfunction in pregnant women using thyroid function tests alone was 12.4% (62) with 9.6% (48) being hypothyroid and 2.0% (10) hyperthyroid. The addition of Tg was able to identify more participants with thyroid dysfunction who were iodine deficient, and initially missed using thyroid function tests alone. This newly added biomarker to routine thyroid function tests profile increased the prevalence of thyroid disorders in this study population from 12.4% (62) to 17.6% (88) (P < 0.01), whereas urine iodine concentration was adequate for each trimester falling within the WHO range of 150–249 μg/l.

Conclusion:
The true prevalence of thyroid dysfunction in pregnant women in Makurdi was 17.6%. The addition of Tg had an impact on thyroid function tests by identifying more participants with iodine-related thyroid dysfunction, who were missed in the initial assessment of the thyroid. The mean urine iodine concentration was adequate, falling within the WHO range of 150–249 μg/l.
Identifying Primary Health-Care Challenges using the Importance–Performance Analysis
Authors: Ogaji Daprim Samuel 
Published: November 2022

Background:
Including patient's evaluation in the comprehensive measurement of primary health-care (PHC) performance is a valid and reliable approach for the assessment and improvement of local PHC system. Aim: This study demonstrates the use of the importance–performance analysis (IPA) for identifying challenges in PHC centers in Obio-Akpor.

Materials and Methods:
This was a quantitative survey of first-time visitors to four PHC centers in Obio-Akpor. A total of 337 participants were selected from a two-stage sampling approach and administered the Patient Evaluation Scale which was structured to elicit their ratings on the importance of PHC centers' attributes before and the performance on these attributes after their encounter with the facility. Descriptive and inferential statistics were performed using the SPSS version 21, and PHC centers' attributes were aggregated across each of the four IPA quadrants.

Results:
The response rate was 89% and the Cronbach's alpha coefficient was 0.91 and 0.94 for the importance and performance measurement scales, respectively. More of the respondents were below 40 years (87.7%), female (73.7%), and currently married (69.3%). Observed areas of concentration for PHC improvement were staff availability during operating times, ease of payment, waiting time, convenience of operating hours, and availability of electricity in the facility.

Conclusion:
Findings provide evidence of patients' concerns in the local PHC system. Subsequent validation and focused interventions aimed at resolving identified challenges can positively influence the demand and social relevance of PHC in this setting.