bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibroblast growth factor 23 (Fgf23) levels and their relationship with disease activity, bone mineral density, and radiological damage score in patients with rheumatoid arthritis: a single center case–control study
Authors: Çelik Direnç Şerif , Ayar Koray , Ermurat Selime , Üstündağ Yasemin 
Published: September 2022

Abstract

Background
There is limited and conflicting information on Fgf23 levels and their relationship with bone loss and disease activity in rheumatoid arthritis (RA). The aim of this study was to compare Fgf23 levels in RA patients with a healthy population and to evaluate the relationship between Fgf23 levels in RA with disease activity, bone mineral density (BMD), and radiological damage score.

Results
The median Fgf23 levels in patients with RA and in hospital staff were 20.06 (11.2–51.0) and 26.40 (12.6–49.5) pg/ml (P < 0.001), respectively. RA patients were divided into active (DAS28 > 3.2) and inactive (DAS28 ≤ 3.2) subgroups. The median Fgf23 levels in active and inactive RA patients were 22.12 (13.90–51.02) and 17.71 (11.20–31.19) pg/ml, respectively (P = 0.001). BMD of RA patients was evaluated with dual-energy X-ray absorptiometry and radiological damage scores were evaluated independently by two investigators using the modified Sharp score (MSS). In RA patients, Fgf23 values correlated with DAS28 and with erosion score of observer-2 (r = 0.297, P = 0.036), but not with erosion score of observer-1 (r = 0.252, P = 0.077). No correlation was found between DAS28 and femur and lumbar vertebra BMD.

Conclusion
In RA, Fgf23 is not associated with BMD but may be associated with local bone loss and disease activity.
National Institutes of Health Stroke Scale Score Less Than 10 at 24 hours After Stroke Onset Is a Strong Predictor of a Favorable Outcome After Mechanical Thrombectomy
Authors: Katano Takehiro , Suzuki Kentaro , Takeuchi Masataka , Morimoto Masafumi , Kanazawa Ryuzaburo , Takayama Yohei , Aoki Junya , Nishiyama Yasuhiro , Otsuka Toshiaki , Matsumaru Yuji , Kimura Kazumi 
Published: September 2022

BACKGROUND:
There are a few accurate predictors of patient outcomes after mechanical thrombectomy (MT).

OBJECTIVE:
To investigate whether the National Institutes of Health Stroke Scale (NIHSS) score 24 hours after stroke onset could predict favorable outcomes at 90 days in patients with acute stroke treated with MT.

METHODS:
Patients from the SKIP study were enrolled in this study. Using receiver operating characteristic curves, the optimal cut-off NIHSS score 24 hours after stroke onset was calculated to distinguish between favorable (modified Rankin Scale score 0-2) and unfavorable (modified Rankin Scale score 3-6) outcomes at 90 days. These receiver operating characteristic curves were compared with those of previously reported predictors of favorable outcomes, such as the ΔNIHSS score (baseline NIHSS score—NIHSS score at 24 h), percent delta (ΔNIHSS score × 100/baseline NIHSS score), and early neurological improvement indices.

RESULTS:
A total of 177 patients (median age, 72 years; female, 65 [37%]) were enrolled, and 109 (61.9%) had favorable outcomes. The respective sensitivity, specificity, and area under the curve values for an NIHSS of 10 were 92.6%, 80.7%, and .906; a ΔNIHSS score of 7 were 70.6%, 76.1%, and .797; and percent delta of 48.3% were 85.3%, 80.7%, and .890.

CONCLUSION:
NIHSS score <10 at 24 hours after stroke onset is a strong predictor of favorable outcomes at 90 days in patients treated with MT.
Interrelated but Not Time-Aligned Response in Myogenic Regulatory Factors Demethylation and mRNA Expression after Divergent Exercise Bouts
Authors: TELLES GUILHERME DEFANTE , LIBARDI CLEITON AUGUSTO , CONCEIÇÃO MIGUEL SOARES , VECHIN FELIPE CASSARO , LIXANDRÃO MANOEL EMÍLIO , MANGONE FLAVIA REGINA ROTEA , PAVANELLI ANA CAROLINA , NAGAI MARIA APARECIDA , CAMERA DONNY MICHAEL , HAWLEY JOHN A. , UGRINOWITSCH CARLOS 
Published: September 2022

ABSTRACT

Introduction
DNA methylation regulates exercise-induced changes in the skeletal muscle transcriptome. However, the specificity and the time course responses in the myogenic regulatory factors DNA methylation and mRNA expression after divergent exercise modes are unknown.

Purpose
This study aimed to compare the time course changes in DNA methylation and mRNA expression for selected myogenic regulatory factors (MYOD1, MYF5, and MYF6) immediately after, 4 h after, and 8 h after a single bout of resistance exercise (RE), high-intensity interval exercise (HIIE), and concurrent exercise (CE).

Methods
Nine healthy but untrained males (age, 23.9 ± 2.8 yr; body mass, 70.1 ± 14.9 kg; peak oxygen uptake [V̇O2peak], 41.4 ± 5.2 mL·kg−1·min−1; mean ± SD) performed a counterbalanced, randomized order of RE (4 × 8–12 repetition maximum), HIIE (12 × 1 min sprints at V̇O2peak running velocity), and CE (RE followed by HIIE). Skeletal muscle biopsies (vastus lateralis) were taken before (REST) immediately (0 h), 4 h, and 8 h after each exercise bout.

Results
Compared with REST, MYOD1, MYF5, and MYF6, mean methylation across all CpGs analyzed was reduced after 4 and 8 h in response to all exercise protocols (P < 0.05). Reduced levels of MYOD1 methylation were observed after HIIE and CE compared with RE (P < 0.05). Compared with REST, all exercise bouts increased mRNA expression over time (MYOD1 at 4 and 8 h, and MYF6 at 4 h; P < 0.05). MYF5 mRNA expression was lower after 4 h compared with 0 h and higher at 8 h compared with 4 h (P < 0.05).

Conclusions
We observed an interrelated but not time-aligned response between the exercise-induced changes in myogenic regulatory factors demethylation and mRNA expression after divergent exercise modes. Despite divergent contractile stimuli, changes in DNA methylation and mRNA expression in skeletal muscle were largely confined to the late (4–8 h) recovery period and similar between the different exercise challenges.
Pharmacy practitioners’ practice, awareness and knowledge about herbal products and their potential interactions with cardiovascular drugs
Authors: Abudalo Rawan , Abudalo Razan , Alqudah Abdelrahim , Abuqamar Ayman , Abdelaziz Amr , Alshawabkeh Maram , Taha Luma 
Published: September 2022

Background:Herbal medicine use is widespread among patients, as community pharmacies may provide such products. Therefore, pharmacy practitioners should be aware of potential herbal products’ adverse effects and herb-drug interactions, particularly with medications for comorbid diseases, such as cardiovascular drugs, in which pharmacy practitioners need to have good knowledge to provide patients with relevant advice to get optimal and safe therapeutic outcomes. Accordingly, the study is designed to assess the knowledge and awareness of pharmacy practitioners regarding herbal product dispensing and cardiovascular drug interaction in Jordan and view their role in patients’ counselling to set up safe and effective drug use.Methods: A cross-sectional study was conducted in Jordan using an online formatted questionnaire distributed to pharmacy practitioners working in community pharmacies. Descriptive and analytical statistics were performed for the responses using the Statistical Package for the Social Sciences (SPSS) software, version 26.Results:Out of 508 participants, 41.7% had medium knowledge of herbal products pertaining mainly to university education (68.1%); 55.1% of participants dispensed herbal products without prescriptions for obesity and weight reduction (72.8%) and gastrointestinal problems (70.9%); this is because respondents agreed that herbal remedies are safe (28.5%) and effective (38.4%). Whilst the knowledge level of respondents about herbal medicine interaction with cardiovascular medication was medium, with a mean of 1.94, as this interaction may result in potentially serious consequences, 40.7% of respondents strongly agreed to gain more knowledge about the side effects of herbal products and medicine interactions through educational courses.Conclusions:The pharmacy practitioners had medium knowledge of herbal products; however, more attention should be paid to herb-drug interactions in the pharmacy educational curriculum. Additionally, pharmacy practitioners need to refresh their knowledge by attending periodic educational courses and by using reliable resources for information about herbal products in order to provide effective and competent pharmaceutical care.
Effect of intraoperative PEEP with recruitment maneuvers on the occurrence of postoperative pulmonary complications during general anesthesia––protocol for Bayesian analysis of three randomized clinical trials of intraoperative ventilation
Authors: Mazzinari Guido , Zampieri Fernando G. , Ball Lorenzo , Campos Niklas S. , Bluth Thomas , Hemmes Sabrine N.T. , Ferrando Carlos , Librero Julian , Soro Marina , Pelosi Paolo , Gama de Abreu Marcelo , Schultz Marcus J. , Serpa Neto Ary ,   PROVHILO investigators,   iPROVE investigators,   PROBESE investigators,   PROVE network investigators
Published: September 2022

Background: Using the frequentist approach, a recent meta–analysis of three randomized clinical trials in patients undergoing intraoperative ventilation during general anesthesia for major surgery failed to show the benefit of ventilation that uses high positive end–expiratory pressure with recruitment maneuvers when compared to ventilation that uses low positive end–expiratory pressure without recruitment maneuvers. Methods: We designed a protocol for a Bayesian analysis using the pooled dataset. The multilevel Bayesian logistic model will use the individual patient data. Prior distributions will be prespecified to represent a varying level of skepticism for the effect estimate. The primary endpoint will be a composite of postoperative pulmonary complications (PPC) within the first seven postoperative days, which reflects the primary endpoint of the original studies. We preset a range of practical equivalence to assess the futility of the intervention with an interval of odds ratio (OR) between 0.9 and 1.1 and assess how much of the 95% of highest density interval (HDI) falls between the region of practical equivalence. Ethics and dissemination: The used data derive from approved studies that were published in recent years. The findings of this current analysis will be reported in a new manuscript, drafted by the writing committee on behalf of the three research groups. All investigators listed in the original trials will serve as collaborative authors.
HR practices and turnover intention; the mediating role of organizational commitment in Tehran: a cross-sectional study
Authors: Hassanpour Mohammaad Kashinejad , Chong Chin Wei , Chong Siong Choy , Ibrahim Okour Mohammad Khaleel , Behrang Samadi , Tan Xin Yee 
Published: September 2022

Background: Employees are increasingly being recognised as a valuable source of information, especially in knowledge-based businesses. Businesses, however, suffer financial and organisational memory losses related to re-hiring and training new staff, and lost productivity and intellectual property because of employee turnover. Hence, employee turnover should be considered an essential part of human resource management. Furthermore, employees’ trust in management and human resource (HR) practices substantially impact organisational commitment (OC). Thus, anticipating employee commitment and turnover intentions is crucial, as people are the sole source for knowledge-based firms to maintain their competitive advantage. In the context of selected Tehran Renewable Energy (RE) firms, this study investigated the mediating impact of OC on the relationship between HR practices (recruitment and selection; training and development opportunities; performance appraisal and evaluation; teamwork; compensation and pay; and job security) and employee turnover intention. Methods: This is a cross-sectional study in Tehran that involved 90 experts and knowledgeable employees from four of Tehran's top RE businesses. A questionnaire was distributed to collect data which was later analysed with correlation, regression and bootstrapping analyses. Results: All six dimensions of HR practices were discovered to have an indirect impact on turnover intention and a direct impact on OC. OC among employees has an indirect effect on turnover intention. It was also revealed that the training and development opportunity has the most considerable effect on OC and turnover intention. OC was not found as a mediator between HR practices and turnover intention. Conclusions: The outcomes of this study showed that both training and development opportunities; and pay and compensation structure were found to be two significant components of HR practices in the relationship with OC. RE managers should employ appropriate HR strategies, particularly in these two dimensions, to improve an individual's degree of OC and reduce turnover intention.
Exacerbation of symptoms of rheumatoid arthritis in the course of immunotherapy of non-small cell lung cancer - an analysis of medical cases and a review of the literature
Authors: Bargieł Julia , Cabaj Justyna , Chmielewska Izabela , Wójcik-Superczyńska Magdalena , Milanowski Janusz 
Published: September 2022

Background: Lung cancer has been at the forefront of cancers with the highest incidence and mortality rates. Nowadays, there are available more effective forms of treatment such as immunotherapy. In the case of cancer cells expressing the PD-L1 receptor, pembrolizumab, atezolizumab and nivolmab are of particular use. While these drugs have the great benefit of stabilizing the disease, they are not without side effects, especially inflammatory changes in the joints. The aim of the study is to show the risk of immunotherapy in the form of exacerbation of inflammatory symptoms in patients with rheumatoid arthritis (RA) as a concomitant disease. Case report: Lung cancer (PD-L1 +) was diagnosed in three patients with a history of RA. After meeting the criteria of the drug program, the patients started molecularly targeted therapy with pembrolizumab and atezolizumab. The applied treatment brought a great benefit in the form of stabilization the neoplastic disease. Over time an exacerbation of inflammatory changes within the joints was noted, which significantly impeded everyday functioning in two patients. Due to this situation, immunotherapy was discontinued. Conlusions: Studies show that as many as 1/4 of patients treated with PD-L1 inhibitors experience side effects related to the autoimmune system. In the case of people suffering from RA, the use of immunotherapy may intensify inflammatory changes and increase pain, which significantly reduce the quality of life. Therefore, the risk of RA exacerbation as a side effect of biological therapy for lung cancer treatment should be popularized. This awareness will enable quick intervention and minimize the number of interrupted immunotherapies.
The role of dietary education and vitamin supplementation in the treatment of Allergic Rhinitis
Authors: Kaczynska Agnieszka , Gorecka Adrianna , Osial Natalia , Klosinska Martyna , Chmiel Paulina 
Published: September 2022

Introduction and purpose
Allergic rhinitis (AR) is a widely prevalent condition which affects mainly children. The disease is not as severe as other allergic disorders; however, its symptoms significantly impact the patient's quality of life. The therapeutic options have limited effectiveness and they are burdened with numerous side effects. In addition, AR’s underlying causes are not fully elucidated; thus, there is an urgent need to conduct more large sample studies on this topic.
State of knowledge
In recent years, research concerning the role of vitamin deficiency in AR pathogenesis gathered pace. Some studies report that children with vitamin A, C and D deficiencies more often suffer from allergic diseases, especially AR and asthma. Furthermore, they are more likely to have severe infections and other disorders caused by immune imbalance. The crucial aspect of vitamins' role in AR is their significant ability to modulate the immune response, especially adaptive, by restoring Th1/Th2 balance. Recent publications reported that vitamin supplementation in AR patients results in an improved clinical course of the disease and restored immune balance. Moreover, vitamins added to the typical treatment improve its effects.
Conclusions
This review aims to summarize the state of knowledge about the role of vitamin A, C and D deficiency in the pathogenesis of AR. Moreover, we point out the values of education in the field of proper dietary habits among AR patients. In addition, the effects of vitamin supplementation in AR patients are also emphasized.
Does body condition scoring portray an accurate representation of a horse's condition when compared to other morphological techniques?
Authors: Turner Alicia , Chapman Stella 
Published: September 2022

Background: The assessment of a horse's condition is generally carried out using body condition scoring, cresty neck scoring or weigh taping. Aim: The objective of this study was to investigate the accuracy of body condition scoring in comparison to other commonly used morphological condition assessment techniques. Methods: A recognised and well-established body condition scale adapted from Henneke et al (1983) was used, and the subsequent scores from this were compared to cresty neck scores, rump width measurements and belly and heart girth measurements. The study was carried out using seven horses and seven volunteers, who assessed each horse identifying any differences or similarities in each assessor's condition assessment. Results: The rump width measurements were the most accurately assessed condition assessment; however, using rump width measurements alone, a whole-body condition assessment cannot be made. Conclusion: It is therefore recommended that it should be combined with other condition assessments to create a whole-body assessment, with detailed localised adiposity information.
Mid-infrared single-photon upconversion spectroscopy based on temporal-spectral quantum correlation
Authors: Cai Yujie , Chen Yu , Xin Xiaoning , Huang Kun , Wu E 
Published: September 2022

Promoting the sensitivity of mid-infrared (MIR) spectroscopy to the single-photon level is a critical need for investigating photosensitive biological samples and chemical reactions. MIR spectroscopy based on frequency upconversion is a compelling pioneer allowing high-efficiency MIR spectral measurement with well-developed single-photon detectors, which overcomes the main limitations of high thermal noise of current MIR detectors. However, noise from other nonlinear processes caused by strong pump fields hinders the development of the upconversion-based MIR spectroscopy to reach the single-photon level. Here, a broadband MIR single-photon frequency upconversion spectroscopy is demonstrated based on the temporal-spectral quantum correlation of non-degenerate photon pairs, which is well preserved in the frequency upconversion process and is fully used in extracting the signals from tremendous noise caused by the strong pump. A correlation spectrum broader than 660 nm is achieved and applied for the demonstration of sample identification under a low incident photon flux of 0.09 average photons per pulse. The system is featured with non-destructive and robust operation, which makes single-photon-level MIR spectroscopy an appealing option in biochemical applications.
Solution-processed electroluminescent white-light-emitting devices based on AIE molecules and Cu-In-Zn-S nanocrystals
Authors: Lv Peiwei , Liu Zhenyang , Zhao Jinxing , Xiong Zuping , Wang Lijin , Li Xu , Qian Zhaosheng , Tang Aiwei 
Published: September 2022

Solution process is a key technique for the manufacture of large-area and low-cost semiconducting devices and, thus, attracts a lot of attention from both academia and industry. Herein, we realized solution-processed light-emitting diodes (excluding a cathode) based on aggregation-induced emission (AIE) molecules of tetraphenylethylene-4Cl (TPE-4Cl) and cadimum-free semiconductor nanocrystals (NCs) for the first time. By mixing Cu-In-Zn-S NCs and TPE-4Cl as an emissive layer, a new type of environmentally friendly white-light-emitting diodes (WLEDs) was prepared through a solution-processed technique. After systematical optimization of the as-prepared WLEDs, the corresponding color rendering index can reach up to 87 with a maximum luminance of

262

cd/

m

2

. This study may pave a new road to realize AIE-based WLEDs through a solution-processed technique.
Risk factors for myopic choroidal neovascularization-related macular atrophy after anti-VEGF treatment
Authors: Bae Ki Woong , Kim Dong Ik , Kim Bo Hee , Oh Baek-Lok , Lee Eun Kyoung , Yoon Chang Ki , Park Un Chul 
Published: September 2022

Purpose
The study aimed to evaluate risk factors for macular atrophy (MA) associated with myopic choroidal neovascularization (mCNV) during long-term follow-up after intravitreal anti-vascular endothelial growth factor (VEGF) treatment in highly myopic eyes.

Methods
The medical records of patients who received intravitreal injection of anti-VEGF agents as mCNV treatment and were followed-up for more than 36 months were retrospectively reviewed. The risk factors for the development of mCNV-MA, which is the fovea-involving patchy atrophy lesion adjacent to mCNV, were investigated using the Cox proportional hazard model.

Results
A total of 82 eyes (74 patients) were included in the study. The mean age at anti-VEGF treatment was 56.3 ± 12.5 years (range, 26–77), and the mean follow-up period was 76.3 ± 33.5 months (range, 36–154). During follow-up, mCNV-MA developed in 27 eyes (32.9%), and its occurrence was estimated to be 24.5% at 3 years and 37.3% at 5 years after the first anti-VEGF treatment. Old age (hazard ratio [HR] = 1.054, 95% confidence interval [CI]: 1.018–1.091; P = 0.003) and greater CNV size at baseline (HR = 2.396, CI: 1.043–5.504; P = 0.040) were significant factors for mCNV-MA development. Eyes with a thinner subfoveal choroid were more likely to show faster enlargement of the mCNV-MA during follow-up.

Conclusions
In mCNV eyes treated with intravitreal anti-VEGF agents, older age and greater mCNV size at baseline were risk factors for the development of MA during long-term follow-up, which was associated with a poor visual prognosis.