bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sperm and testicular tissue cryopreservation and assisted reproductive technology outcomes in male cancer patients: a 15-year experience
Authors: Fernández-González Marta J. , Radauer-Plank Anne-Catherine , Stelzer Cornelia , Geiger Waldemar , Goranova Irena , Borgmann-Staudt Anja , Balcerek Magdalena , Wilkemeyer Ina 
Published: November 2022

Abstract
Objective
To explore the characteristics of cancer patients who cryopreserved sperm/testicular tissue samples in the Cryobank of Charité-Universitätsmedizin Berlin between 2004 and 2019, and the ART utilization rate with associated outcomes.

Methods
Retrospective data were available for 506 cancer patients, of which 46 (9.1%) had used their samples for artificial reproductive technologies (ART). Corresponding cycle information was collected from external fertility centers.

Results
Our cohort included 53/506 (10.5%) patients aged < 18 years at diagnosis. While adolescents and adults mainly banked sperm, adolescents showed higher rates of testicular tissue cryopreservation before (11.8%, 6/51 vs. 6.4%, 26/406) and after treatment (16.7%, 4/24 vs. 7.8%, 13/167). At study conduction, storage had been ended for 44.8% (269/601) of samples. The majority of samples used for ART were requested within the first 3 years after cryopreservation (71.5%, 28/39, range = 0–12 years). Pregnancy rate was 51.4% (19/37 cycles), resulting in 11 singleton births, 3 twin pairs, and 4 miscarriages.

Conclusion
With the new advantage of public health insurance coverage of fertility preservation (FP) in Germany, an increased utilization has already been noticed in our center, emphasizing the necessity of further knowledge for individual counseling. Adolescent cancer patients need to be addressed specifically, as these patients show especially low cryopreservation rates.
The genetics of monogenic intestinal epithelial disorders
Authors: Babcock Stephen J. , Flores-Marin David , Thiagarajah Jay R. 
Published: November 2022

AbstractMonogenic intestinal epithelial disorders, also known as congenital diarrheas and enteropathies (CoDEs), are a group of rare diseases that result from mutations in genes that primarily affect intestinal epithelial cell function. Patients with CoDE disorders generally present with infantile-onset diarrhea and poor growth, and often require intensive fluid and nutritional management. CoDE disorders can be classified into several categories that relate to broad areas of epithelial function, structure, and development. The advent of accessible and low-cost genetic sequencing has accelerated discovery in the field with over 45 different genes now associated with CoDE disorders. Despite this increasing knowledge in the causal genetics of disease, the underlying cellular pathophysiology remains incompletely understood for many disorders. Consequently, clinical management options for CoDE disorders are currently limited and there is an urgent need for new and disorder-specific therapies. In this review, we provide a general overview of CoDE disorders, including a historical perspective of the field and relationship to other monogenic disorders of the intestine. We describe the genetics, clinical presentation, and known pathophysiology for specific disorders. Lastly, we describe the major challenges relating to CoDE disorders, briefly outline key areas that need further study, and provide a perspective on the future genetic and therapeutic landscape.
Effect of temporary cements and their removal methods on the bond strength of indirect restoration: a systematic review and meta-analysis
Authors: Ding Jingyu , Jin Yifu , Feng Shanshan , Chen Huan , Hou Yanyan , Zhu Song 
Published: November 2022

AbstractObjectivesFor a conventional indirect restoration, temporary cementation inevitably contaminated collapsed dentin collagen. The purpose of this review was to evaluate the optimal strategy for minimizing its negative effects.Material and methodsDatabases such as PubMed, Web of Science, EMBASE, and the Cochrane Library were searched for in vitro studies, involving the influence of immediate dentin sealing (IDS), different temporary cements, and their removal strategies on dentin bond strength. The meta-analysis used the inverse variance method with effect method of the standardized mean difference and statistical significance atp ≤ 0.05. TheI2value and theQ-test were used to assess the heterogeneity.ResultsA total of 14 in vitro trials were subjected to the meta-analysis. Within the study’s limitations, we assumed that IDS eliminated the negative effects of temporary bonding, achieving the comparable immediate bond strength with the control (p = 0.46). In contrast, under delayed dentin sealing (DDS), temporary cementation statistically decreased bond strength (p = 0.002). Compared with resin-based and non-eugenol zinc oxide cements, polycarboxylate and calcium hydroxide cements performed better on bond strength with no statistical difference from the control group (p > 0.05). Among the removal methods of temporary cements, the Al2O3abrasion restored the decreased bond strength (p = 0.07) and performed better than hand instruments alone (p = 0.04), while pumice removal slightly reduced the bond strength in contrast with the control group (p = 0.05, 95% CI =  − 1.62 to 0).ConclusionsThe choices of IDS, polycarboxylate and calcium hydroxide temporary cements, Al2O3abrasion removal method were feasible and efficient to enhance the bond strength.Clinical relevanceIt is worthwhile applying IDS technique, polycarboxylate and calcium hydroxide temporary cements during indirect restoration. The Al2O3abrasion of cleaning dentin can minimize the negative effects of temporary cement.
Selective mutism and the risk of mental and neurodevelopmental disorders among siblings
Authors: Koskela Miina , Jokiranta-Olkoniemi Elina , Luntamo Terhi , Suominen Auli , Sourander Andre , Steinhausen Hans-Christoph 
Published: November 2022

AbstractThe siblings of children with mental disorders are more likely to experience mental health issues themselves, but there has been a lack of sibling studies on selective mutism (SM). The aim of this population-based study was to use national registers to examine associations between children with SM and diagnoses of various mental disorder in their siblings. All singleton children born in Finland from 1987 to 2009, and diagnosed with SM from 1998 to 2012, were identified from national health registers and matched with four controls by age and sex. Their biological siblings and parents were identified using national registries and the diagnostic information on the siblings of the subjects and controls was obtained. The final analyses comprised 658 children with SM and their 1661 siblings and 2092 controls with 4120 siblings. The analyses were conducted using generalized estimating equations. Mental disorders were more common among the siblings of the children with SM than among the siblings of the controls. The strongest associations were observed for childhood emotional disorders and autism spectrum disorders after the data were adjusted for covariates and comorbid diagnoses among SM subjects. The final model showed associations between SM and a wide range of disorders in siblings, with strongest associations with disorders that usually have their onset during childhood. Our finding showed that SM clustered with other mental disorders in siblings and this requires further research, especially the association between SM and autism spectrum disorders. Strong associations with childhood onset disorders may indicate shared etiologies.
Evidence of karstification in chalk and limestone aquifers connected with stream systems and possible relation with the fish ecological quality ratio in Denmark
Authors: Nilsson Bertel , Li Fulin , Chen Huawei , Sebok Eva , Henriksen Hans Jørgen 
Published: November 2022

AbstractAlthough chalk aquifers are not too often associated with conduit flow, they are highly productive groundwater systems and, like limestone aquifers, they can be vulnerable to contamination when exposed to land use activities. The Danish carbonate rocks are generally recognized to be highly fractured and covered by thick Quaternary sediments. Fissure flow is pronounced, occurring in the upper 50–100 m due to Pleistocene glaciations. According to recently published maps of the distribution of karst in Europe, Denmark has no karst. However, this study concludes that karstified chalk and limestone aquifers are an important source of freshwater in Denmark. Four national datasets on karst features, groundwater flow, groundwater chemistry, and fish ecological quality ratio (EQR) data now indicate more heterogeneous structures and preferential flow pathways in the chalk and limestone aquifers than had been conceptualized and modelled with a national water resources groundwater/surface-water model in the recent past. This study provides new qualitative evidence that rapid and preferential flow of water and agrochemicals from the surface through thinner parts of the Quaternary cover layers, sinkholes and solution-enlarged fractures may likely impact the vulnerability of chalk and limestone aquifers. Additionally, due to the preferential flow system, some gaining streams discharged by karstified chalk and limestone aquifers show increased fish EQR values when using observed river daily discharge data instead of simulated daily discharge.
Impact of clinical pharmacist discharge prescription review on the appropriateness of antibiotic therapy: a retrospective comparison
Authors: Spigelmyer Amy , Howard Catessa , Rybakov Ilya , Burwell Sheena , Slain Douglas 
Published: November 2022

Abstract
Background
Inappropriate antibiotic prescribing upon hospital discharge has been identified as a significant problem. Despite high rates of antibiotic prescription errors, there is no widely accepted antimicrobial stewardship initiative to prevent such errors.

Aim
The primary objective of this study was to determine the impact of hospital-based clinical pharmacist discharge prescription review on the appropriateness of antibiotic prescriptions.

Method
This was an observational study comparing the appropriateness of hospital discharge antibiotic prescriptions between two similar internal medicine services. One cohort of patients was admitted to medicine services where rounding clinical pharmacists performed routine antibiotic discharge assessment, and the comparator cohort was admitted to hospitalist services without routine pharmacist discharge antibiotic review.

Results
Our study included 150 cases per cohort. Baseline characteristics were similar between groups, except for increased age (p = 0.025) and fewer cases of acute bacterial skin & skin structure infections (p = 0.001) in the hospitalist cohort. Antibiotic appropriateness was considerably greater in the medicine (pharmacist) group versus hospitalist group [(83% versus 54%, respectively (p < 0.00001)]. The difference in appropriateness was mainly driven by pneumonia and urinary tract infection prescriptions.

Conclusion
Appropriateness of antibiotic prescriptions significantly improved in the setting of pharmacist discharge review. This initiative highlights the important role of clinical pharmacists in outpatient antimicrobial stewardship.
Working from home for good? Lessons learned from the COVID-19 pandemic and what this means for the future of work
Authors: Kagerl Christian , Starzetz Julia 
Published: November 2022

AbstractIn the wake of the COVID-19 pandemic, more firms than ever before have enabled their employees to work from home. Based on a representative firm survey in Germany, surveying 2.000 firms per month throughout the course of the pandemic (October 2020 until June 2022), this paper provides suggestive evidence concerning the effects of working from home (WFH) at different points in time during the pandemic and discusses implications for the future of work. We assess the potential of WFH in Germany to be 25–30% of private-sector employees. On the firm side, we find that higher WFH use is positively related to business success during the crisis, with increased employee productivity and employees working more hours when remote being possible mechanisms. Larger firms in particular are open towards expanding their WFH offerings in the future. During the pandemic, firms have experienced that WFH has worked well in many respects (e.g., productivity of employees, quality of work performed) and, for the future, they are willing to facilitate WFH in order to give their employees more flexibility, and to be considered an attractive employer. However, working on site brings advantages (e.g., communication, cooperation and onboarding of new employees) firms will not want to sacrifice, pointing towards a hybrid model of work.
Obstetric and offspring outcomes in isolated maternal hypothyroxinaemia: a systematic review and meta-analysis
Authors: Zhuo L. , Wang Z. , Yang Y. , Liu Z. , Wang S. , Song Y. 
Published: November 2022

Abstract
Objective
To examine the association between isolated maternal hypothyroxinaemia (IMH) and adverse obstetric outcomes and offspring outcomes and also investigate the effects of levothyroxine therapy on IMH for the above outcomes.

Methods
We systematically searched PubMed, EMBASE, and Cochrane Library, and the reference lists of key reviews were hand searched on June 9, 2021. Two authors independently screened titles/abstracts. Full articles were further assessed if the information suggested that the study met the inclusion/exclusion criteria, and two researchers performed data extraction and risk-of-bias assessment using standardized tables. Summary relative risks or the mean difference between maternal effects and offspring outcomes were calculated by a random-effects model.

Results
We identified 38 eligible articles (35 cohort studies and two randomized controlled trials [RCT]). Meta-analysis showed that maternal IMH was associated with increased gestational diabetes mellitus, preterm premature rupture of membranes, preterm birth, fetal distress, and macrosomia outcomes in IMH compared to euthyroid women, and the relative risks were 1.42 (1.03–1.96), 1.50 (1.05–2.14), 1.33 (1.15–1.55), 1.75 (1.16–2.65) and 1.62 (1.35–1.94), respectively. IMH was not associated with placenta previa, gestational hypertension, pre-eclampsia, intrauterine growth restriction, and offspring outcomes like birth weight, low birth weight infants, fetal macrosomia, neonatal intensive care, neonatal death, or fetal head circumference. In addition, we did not find an association between IMH and adverse offspring cognitive defects. Due to insufficient data for meta-analysis, it failed to pool the evidence of levothyroxine’s therapeutic effect on IMH and their offspring.

Conclusions and relevance
IMH in pregnancy may relate to a few maternal and offspring outcomes. Moreover, there is currently no sufficient evidence that levothyroxine treatment during pregnancy reduces adverse maternal outcomes and disability in offspring. Further investigation to explore the beneficial effects of levothyroxine therapy is warranted.
Understanding the Impact of COVID-19 on People with Severe and Persistent Mental Illness within Rehabilitation Services: A Thematic Analysis
Authors: Pervan Luke , Parker Stephen , Wheeler Maddison , Dark Frances 
Published: November 2022

Abstract The COVID 19 pandemic has required major changes in healthcare delivery. This study sought to understand the impact of the mental healthcare changes associated with COVID-19 on people living with severe and persisting mental illness (SPMI) and staff working in rehabilitation teams in Queensland in Australia. Telephone interviews were completed with participants diagnosed with SPMI who were supported by the rehabilitation teams of a public mental health service (n = 18). Additionally, an anonymous survey was completed with staff from these teams (n = 20, 17.5% of staff). Both datasets were analysed separately using thematic analysis. Four themes were identified through the analysis of the patient interviews: wishing the whole thing would go away; [COVID-19 has] delayed my recovery; being more socially aware; and (you've) got to be clean (which is a) good thing. Four themes emerged through the analysis of the staff survey data: needing to change the model of care; impact on patients, the impact on staff, positive impact. The perceived impact on participant’s mental health was like that which was reported in the general population. Participants’ emphasised anxiety, loneliness, boredom, and depression rather than a relapse of their primary psychotic illness. Participants noted the pandemic slowed the pace of personal recovery and limited the delivery of specialised rehabilitation programs.
Model Inversion for Precise Path and Trajectory Tracking in an Underactuated, Non-Minimum Phase, Spatial Overhead Crane
Authors: Bettega Jason , Richiedei Dario , Tamellin Iacopo , Trevisani Alberto 
Published: November 2022

Abstract
Purpose
This paper proposes a motion planning technique for precise path and trajectory tracking in an underactuated, non-minimum phase, spatial overhead crane. Besides having a number of independent actuators that is smaller than the number of degrees of freedom, tip control on this system presents unstable internal dynamics that leads to divergent solution of the inverse dynamic problem.

Method
The paper exploits the representation of the controlled output as a separable function of the actuated (i.e., the platform translations) and unactuated (i.e., the swing angles) coordinates to easily formulate the internal dynamics, without any approximation, and to study its stability. Then, output redefinition is adopted within the internal dynamics to stabilize it, leading to stable and causal reference commands for the platform translations.

Results
Besides proposing the theoretical formulation of this novel method, the paper includes the numerical validation and the experimental application on a laboratory setup. Comparison with the state-of-the-art input shaping is also proposed.

Conclusion
The results, obtained through different reference trajectories, clearly show that almost exact tracking is obtained also in the experiments, by outperforming the benchmarks.
True uncertainty and ethical AI: regulatory sandboxes as a policy tool for moral imagination
Authors: Undheim Kristin , Erikson Truls , Timmermans Bram 
Published: November 2022

AbstractWe offer a complementary view to the ethical dilemmas discussed in the recent literature by pointing at the epistemological dilemma of true uncertainty, suggesting regulatory sandboxes as an apposite remedy. Using the exemplar case of the regulative sandbox for responsible artificial intelligence established by the Norwegian data protection authorities, we argue that regulative sandboxes have the potential of supporting the development of a more ethical AI through not only reducing uncertainty, but through nurturing moral imaginations.
Accuracy of estimates of serving size using digitally displayed food photographs among Japanese adults
Authors: Shinozaki Nana , Murakami Kentaro 
Published: November 2022

Abstract
We evaluated the accuracy of the estimated serving size using digital photographs in a newly developed food atlas. From 209 food items in the food atlas, we selected 14 items with various appearances for evaluation. At the study site, fifty-four participants aged 18–33 years served fourteen foods in the amount they usually ate. After they left, each food item was weighed by a researcher. The following day, the participants estimated the quantity of each food they served based on food photographs using a web-based questionnaire. We compared the weights of the foods the participants served (true serving sizes) and those determined based on the photographs (estimated serving sizes). For ten of the fourteen food items, significant differences were observed between the estimated and true serving sizes, ranging from a 29⋅8 % underestimation (curry sauce) to a 34⋅0 % overestimation (margarine). On average, the relative difference was 8⋅8 %. Overall, 51⋅6 % of the participants were within ±25 % of the true serving size, 81⋅9 % were within ±50 % and 93⋅4 % were within ±75 %. Bland–Altman plots showed wide limits of agreement and increased variances with larger serving sizes for most food items. Overall, no association was found between estimation errors and participant characteristics. The food atlas has shown potential for assessment of portion size estimation. Further development, refinement and testing are needed to improve the usefulness of the digital food photographic atlas as a portion size estimation aid.
A restrictive, parsimonious theory of footing in directional Harmonic Serialism
Authors: Lamont Andrew 
Published: November 2022

AbstractThis paper develops a theory of footing in Harmonic Serialism (HS; Prince & Smolensky 1993/2004; McCarthy 2000, 2016) where Con contains only directionally evaluated constraints (Eisner 2000, 2002; Lamont 2019, 2022a, 2022b). Directional constraints harmonically order candidates by the location of violations rather than the total number of violations. A central result of adopting directional evaluation is that the constraint Parse($\sigma$) not only motivates iterative footing but also determines where feet surface. This obviates the need for alignment constraints (McCarthy & Prince 1993; McCarthy 2003; Hyde 2012a, 2016), which determine where feet are parsed in HS with constraints that count loci (Pruitt 2010, 2012). The theory uses fewer constraints, is empirically adequate, and makes more restrictive predictions than HS with counting constraints and parallel Optimality Theory (Prince & Smolensky 1993/2004) with directional constraints.
An Interactive Simulation and Visualization Tool for Conventional and Aberration-Corrected Transmission Electron Microscopy
Authors: Li X-Z 
Published: November 2022

Abstract:
Contrast transfer function (CTF) is a vital function in transmission electron microscopy (TEM). It expresses to what extent amplitudes converted from the phase changes of the diffracted waves contribute to the TEM image, including the effects of lens aberrations. Simulation is very helpful to understand the application of the function thoroughly. In this work, we develop the CTFscope as a component in the Landyne software suite, to calculate the CTF with temporal and spatial dumping envelopes for conventional TEM and to extend it to various aberrations (up to fifth order) for aberration-corrected (AC)-TEM. It also includes effects on the CTF and imaging due to the objective aperture and image drift for tutorial purposes. The CTFscope has a user-friendly graphical interface for simulation, visualization, saving, and loading of the microscopy conditions and results. It can be used to explore instrumental performance information due to optical aberrations, effects on the resolution of a TEM and AC-TEM, and for teaching electron microscopy courses.