bluuebunny/crossref_metadata_2025_split huggingface dataset:
Siloxane‐Mediated Schiff Base Bio‐Based Curing Agent: Achieving Epoxy Vitrimer with Excellent Mechanical Properties, Low Dielectric Constant and Rapid Degradation Characteristics
Authors: Wang Yonghui , Xiao Xingzhen , Chen Xinrong , Zhong Wei , Lan Jiashui , Lai Geng , Zhang Huagui , Chen Mingfeng 
Published: February 2025

AbstractEpoxy resin is indispensable in various applications due to its outstanding properties. However, its limited recyclability and associated environmental issues pose significant challenges for sustainable development. To address this issue, integrating recyclable Schiff base groups into epoxy resin systems to construct epoxy vitrimer with dynamic properties has become a promising strategy. Herein, a rapid degradation, enhanced mechanical properties, and low dielectric constant epoxy vitrimer (EP‐BOB) is proposed through a unique rigid‐flexible structure bio‐based curing agent (BOB). BOB is synthesized using siloxane as a flexible chain to bridge with vanillin in a one‐pot process. The incorporation of the Schiff base structure imparted exceptional degradability to EP‐BOB, allowing it to fully degrade within 45 min. In addition, due to the unique rigid‐flexible structure, EP‐BOB exhibited lower dielectric constant (1.2–2.6) and outstanding mechanical properties (60.5 MPa tensile strength). Furthermore, Raman spectroscopy and scanning electron microscopy shows that EP‐BOB can be completely degraded in the amine solution to recycle carbon fibers (CFs) without damage. Especially, the Schiff base can endow EP‐BOB UV‐shielding and antibacterial properties. This work opens up a new strategy for designing a rigid‐flexible structure epoxy vitrimer using silicone to achieve multifunctional and high‐performance EP.
Developing a microfluidic‐based epicPCR reveals diverse potential hosts of the mcrA gene in marine cold seep
Authors: Shen Wenli , Wang Danrui , Li Jiangtao , Liu Yue , Wang Yinzhao , Yang Xingsheng , Peng Xi , Xie Bingliang , Su Lei , Wei Ziyan , He Qing , Wang Zhiyi , Feng Kai , Du Wenbin , Deng Ye 
Published: February 2025

AbstractAnaerobic methanotrophic (ANME) microbes play a crucial role in the bioprocess of anaerobic oxidation of methane (AOM). However, due to their unculturable status, their diversity is poorly understood. In this study, we established a microfluidics‐based epicPCR (Emulsion, Paired Isolation, and Concatenation PCR) to fuse the 16S rRNA gene and mcrA gene to reveal the diversity of ANME microbes (mcrA gene hosts) in three sampling push‐cores from the marine cold seep. A total of 3725 16S amplicon sequence variants (ASVs) of the mcrA gene hosts were detected, and classified into 78 genera across 23 phyla. Across all samples, the dominant phyla with high relative abundance (>10%) were the well‐known Euryarchaeota, and some bacterial phyla such as Campylobacterota, Proteobacteria, and Chloroflexi; however, the specificity of these associations was not verified. In addition, the compositions of the mcrA gene hosts were significantly different in different layers, where the archaeal hosts increased with the depths of sediments, indicating the carriers of AOM were divergent in depth. Furthermore, the consensus phylogenetic trees of the mcrA gene and the 16S rRNA gene showed congruence in archaea not in bacteria, suggesting the horizontal transfer of the mcrA gene may occur among host members. Finally, some bacterial metagenomes were found to contain the mcrA gene as well as other genes that encode enzymes in the AOM pathway, which prospectively propose the existence of ANME bacteria. This study describes improvements for a potential method for studying the diversity of uncultured functional microbes and broadens our understanding of the diversity of ANMEs.
Update on Exercise in Persons With Muscle Disease
Authors: Mamarabadi Mansoureh , Kudritzki Virginia , Li Yuebing , Howard Ileana M. 
Published: February 2025

ABSTRACTMyopathies are heterogeneous in their etiology, muscle group involvement, clinical manifestation, and progression. Deficits in myopathy may include muscle weakness, atrophy, stiffness, myalgia, and extra‐muscular manifestations. Consequently, these deficits could lead to impaired musculoskeletal function, inadequate engagement in daily activities and reduced participation in social activities. Exercise has been viewed as a potentially efficacious intervention to halt the loss of muscle function and to improve secondary symptoms that result from muscle loss, such as pain and fatigue. The purpose of this review is to discuss research findings within the last 10 years that examine effects of exercise interventions in many types of myopathies in humans. In general, most studies were small scale, and they varied with respect to exercise type, intensity, and outcome measures. Despite the different pathologies, various exercise subtypes of aerobic/endurance or strength/resistance training are generally beneficial and may improve muscle strength and functional outcomes. Exercise therapies are generally safe and well tolerated. Exercise prescription should be part of routine neuromuscular care for patients with myopathy, and ideally with input from a multidisciplinary team, with a focus on providing individualized exercise regimens. Further work is needed to define the optimal intensity and type of exercise to result in the best functional outcomes for persons with myopathy, as well as the effects of combining exercise and novel disease modifying therapies.
Tensile, flexural, and vibration analysis of MWCNT‐basalt sandwich composites for car bonnet utility
Authors: Sahu Dhaneshwar Prasad , Das Ramyaranjan , Prusty Jagesh Kumar , Mohanty Sukesh Chandra 
Published: February 2025

AbstractThis study explores the potential of sandwich plates (SPs) with basalt fiber laminated composite face layers and a polyethene terephthalate (PET) foam core, enhanced with varying weight percentages of multiwalled carbon nanotube (MWCNT) contents (0%, 0.1%, 0.3%, 0.5%, and 0.7%), for car bonnet applications. The face layers were fabricated using the hand layup technique, and the material properties of the MWCNT‐enhanced composites and PET core were characterized through uniaxial tension and compression tests. Numerical simulations in ABAQUS employing 3D solid elements (C3D8R) were conducted to predict dynamic responses, validated through experimental modal analysis (EMA) using impact hammer testing in Pulse Lab software. Flexural behavior was assessed via three‐point bending tests, demonstrating optimal mechanical performance at 0.5% MWCNT loading, with peak flexural modulus, strength, toughness, and interlaminar shear strength (ILSS). Higher MWCNT concentrations led to diminished properties. These findings offer critical insights for designing lightweight and high‐performance hybrid composite structures suitable for automotive bonnet systems.Highlight
The flexural and dynamic responses of MWCNTs‐basalt skins/PET foam core‐based sandwich plates.
Tensile and flexural responses increase up to 0.5 wt% of MWCNTs.
Experimental modal analysis is performed for free vibration analysis.
The proposed laminated composite is designed to enhance the utility and performance of car bonnets.
Lay‐up defects inspection for automated fiber placement with structural light scanning and deep learning
Authors: Tang Chongrui , Sun Deyong , Zou Jianchao , Xiong Yifeng , Fang Guoxin , Zhang Weizhao 
Published: February 2025

AbstractAutomated fiber placement (AFP) is an advanced manufacturing technology for large‐scale carbon fiber reinforced plastics (CFRP) composite parts. During AFP processes, unidirectional CFRP prepreg tapes are laid up on the mold to become laminates by a robotic arm under heating and pressure conditions. However, the efficient monitoring of lay‐up defects during AFP, especially the out‐of‐plane defects including wrinkles, bridging, gaps, and overlaps, needs more advanced solutions, as manual inspection of the lay‐up defects still accounts for a large proportion of real manufacturing processes at present. To tackle this issue, an innovative method to realize efficient and accurate detection of AFP lay‐up defects was developed in this work. First, a bespoke AFP platform containing a 5‐degree‐of‐freedom moving platform, air cylinder, compaction roller, heating gun, and structural‐light camera was constructed for AFP experiments. A defect detection algorithm based on PointNet++, a convolutional neural network (CNN) for 3D point cloud segmentation, was then created. PointNet++ was trained by the dataset containing 3D point clouds of intentionally laid‐up defects, which were created on the AFP platform and captured by the structural‐light camera. Compared to the existing AFP defect inspection methods, such as laser profilometer and thermography, this method has the advantages of low cost and convenience to operate. The completed method was experimentally validated to be capable of precisely tracking the locations of out‐of‐plane AFP defects in less than 1 second. The detection accuracy of the method can achieve above 72% in Intersection over Union (IoU) for the out‐of‐plane defects.Highlights
A lay‐up defect detection method for AFP by structural light scanning.
3D point cloud segmentation by PointNet++ was used for defect segmentation.
A bespoke AFP platform was constructed for AFP experiments.
The method can track the locations of AFP defects in less than 1 second.
The method has the advantages of low cost and convenience to operate.
Local p + Poly‐Si Passivating Contacts Realized by Direct FlexTrail Printing of Boron Ink and Selective Alkaline Etching for High Efficiency TOPCon Based Solar Cells
Authors: Uygun Berkay , Kluska Sven , Polzin Jana‐Isabelle , Schube Jörg , Jahn Mike , Krieg Katrin , Turan Raşit , Nasser Hisham 
Published: February 2025

ABSTRACTIn this work, we demonstrate the formation of local boron‐doped, SiOₓ/p + poly‐Si structures using wet chemical etching by direct printing of boron‐ink. FlexTrail printing uses a very hollow (orders of μm for diameter) glass capillary tube filled with boron ink for printing onto silicon substrate. This process represents a mask‐free approach for the formation of local TOPCon structures, enabling high‐efficiency tunnel oxide passivating contact (TOPCon) solar cells. The factors influencing etch‐back selectivity between intrinsic and boron‐doped poly‐Si were thoroughly investigated. It was determined that pre‐treatment with diluted HF (1 wt%) prior to poly‐Si removal in a KOH solution is the most critical step to achieve optimal etch selectivity. This treatment effectively removes the native oxide on intrinsic poly‐Si while preserving the boron silicate glass (BSG) layer on p + poly‐Si, facilitating the selective removal of intrinsic poly‐Si and the formation of p + TOPCon structures. Line widths ranging from 24.0 to 100.5 μm on planar surfaces and 40.0–86.0 μm on textured surfaces were achieved. FlexTrail printing allows for significantly lower (and higher) feature sizes, but its fine‐line potential was not fully exploited here due to alignment challenges during post‐processing. Test structures with a line grid of local TOPCon structures exhibited a maximum open‐circuit voltage (𝑖VOC of 720 mV and a lowest saturation current density (𝐽0𝑆𝐸) of ~90–120 fA/cm2. The developed local p + poly‐Si will be integrated into high‐efficiency TOPCon solar cells, where p + poly‐Si will be strategically placed under the metal contact, in the near future.
Predictors and Impact of Disclosure Efficacy Among Cancer Survivors
Authors: Rabin Carolyn 
Published: February 2025

ABSTRACTBackgroundCancer survivors who disclose their cancer diagnosis and cancer‐related experiences derive a variety of benefits including enhanced quality of life. Given this, it would be helpful to better understand the factors that facilitate disclosure among survivors. Disclosure efficacy—confidence that one can successfully execute a self‐disclosure—may play a key role.AimsIn Study 1, survey data were analyzed to identify potential predictors of disclosure efficacy among cancer survivors and whether disclosure efficacy predicts intention to self‐disclose in the future. In Study 2, a randomized, controlled design was used to evaluate whether psychoeducation about self‐disclosure boosts disclosure efficacy.MethodsData were analyzed from 181 cancer survivors who participated in a cross‐sectional, online survey study (Study 1) and randomized controlled test of disclosure‐related psychoeducational material (Study 2).ResultsThe results from Study 1 indicated that, as hypothesized, having engaged in more cancer‐related disclosure in the past predicted higher levels of disclosure efficacy (though response to prior disclosures did not) and greater disclosure efficacy predicted greater intention to disclose again in the future. The results from Study 2 did not demonstrate that reading psychoeducational information on self‐disclosure enhanced disclosure efficacy. However, exploratory analyses indicated that those receiving this information reported greater intention to engage in three of the four recommended, empirically based disclosure strategies.ConclusionsFindings underscore the role of disclosure efficacy in facilitating cancer‐related disclosure among cancer survivors. Likewise, findings suggest the utility of developing interventions that enhance disclosure efficacy and provide opportunities for behavioral rehearsal of cancer‐related disclosures.
A comprehensive quality control algorithm for atmospheric motion vectors and its impacts on analysis and forecast of the China Meteorological Administration Global Forecast System
Authors: Wang Jincheng , Feng Jie , Yang Yi , Hu Jianglin , Yang Junli 
Published: February 2025

AbstractAtmospheric motion vector (AMV) data play a crucial role in improving the forecast skills of models. Quality control is an essential step that affects the assimilation effectiveness of the AMVs. In a bid to rectify the deviation issue of the initial (analysis) atmospheric dynamic field in the troposphere and to improve AMV assimilation and the forecast skill of the China Meteorological Administration Global Forecast System (CMA‐GFS), a comprehensive quality control (CQC) method is proposed in this study. The CQC encompasses a quality indicator check and blacklist establishment for the AMVs, as well as the background field check based on biweight statistics in the bivector space. Detailed analysis of AMV data eliminated by CQC steps reveals its effectiveness in excluding high and low wind speed outliers, normalizing the probability density function (PDF) of observation‐minus‐background (O − B) values to a Gaussian distribution, thus resolving leptokurtic and platykurtic distribution issues. A 35‐day assimilation sensitivity experiment shows that the original quality control (OQC) increases analysis and forecast errors, especially in tropical wind fields by over 10%. In contrast, CQC significantly reduces these errors, with an average tropospheric dynamic field error decrease of over 3% in the Southern Hemisphere. The CQC's biweight method in bivector space demonstrates potential for quality control of atmospheric dynamic field observations.
SPECIFIC: A systematic framework for engineering cell state‐responsive synthetic promoters reveals key regulators of T cell exhaustion
Authors: Zhang Zhaoyu , Qiu Xiaoyu , Ning Hui , Huang Zihua , Tao Minzhen , Liang Min , Xie Zhen 
Published: February 2025

AbstractCell state‐specific synthetic promoters are essential tools for studying and manipulating cellular function, yet their design remains challenging, particularly for complex states such as T cell exhaustion. Here we present SPECIFIC (Synthetic Promoter Engineering for Cellular State Identification and Functional Analysis), an integrated framework that leverages chromatin accessibility profiling and machine learning to systematically identify and validate cell state‐specific synthetic promoters. By comparing exhausted T cells from both mouse OT‐I and human CAR‐T models, we identified 56 conserved transcription factor binding motifs associated with T cell exhaustion. From these motifs, we engineered a subset of the most promising candidates into synthetic promoters driving an exhaustion‐responsive gene circuit that senses and responds to T cell dysfunction. Several synthetic promoters, particularly those containing NFATc2 or MEF2C binding sites, demonstrated remarkable specificity in recognizing the exhausted state and effectively attenuated T cell dysfunction by reducing both CAR expression and exhaustion markers. This study establishes a generalizable approach for designing cell state‐specific regulatory elements and provides new strategies for improving CAR‐T cell therapy through programmed control of gene expression.
A new critical curve for systems of evolution equations with semilinear coupling
Authors: D’Abbicco Marcello , Lagioia Antonio 
Published: February 2025

Abstract
In this work, we consider a two by two system of evolution equations with a semilinear coupling. We provide sufficient conditions on the power nonlinearities in the coupling term which guarantee the existence of global-in-time small data solutions. In particular, the coupling powers’ interplay is described by two different critical curves. We show the optimality of both critical curves, providing counterpart nonexistence results. One of the curves is analogous to the critical curve of similar evolution systems, while the second one is new for these models. This latter curve also appears if we couple a linear equation and a semilinear equation, under suitable initial data assumption. We also consider the case in which a noneffective damping is applied to the system.
Susceptibility Vessel Sign and Intravenous Alteplase in Stroke Patients Treated with Thrombectomy
Authors: Beyeler Morin , Rohner Roman , Ijäs Petra , Eker Omer F. , Cognard Christophe , Bourcier Romain , Sibon Igor , Lefebvre Margaux , Richard Sébastien , Consoli Arturo , Moulin Solène , Ernst Marielle , Ribo Marc , Barbier Charlotte , Nikoubashman Omid , Liebeskind David S. , Goeldlin Martina B. , Piechowiak Eike I. , Bütikofer Lukas , Gralla Jan , Fischer Urs , Kaesmacher Johannes ,   the SWIFT DIRECT investigators
Published: February 2025

Abstract

Background
The susceptibility vessel sign (SVS) on baseline MRI in acute ischemic stroke patients has been associated with better outcomes post-thrombectomy. This study aimed to investigate whether the presence of the SVS modifies the treatment effect of intravenous thrombolysis plus endovascular thrombectomy (IVT + EVT) versus thrombectomy alone (EVT alone).

Methods
In this secondary analysis of the SWIFT DIRECT trial, comparing IVT + EVT versus EVT alone, treatment effect and its heterogeneity were assessed with rates of pre-interventional reperfusion (eTICI 2a–3) and successful post-interventional reperfusion (eTICI of 2b–3) according to the SVS status using adjusted multivariable logistic regression. Secondary objectives were to analyze whether the presence of SVS or its individual characteristics (location, length, width, overestimation ratio, two-layered sign) were associated with outcomes.

Results
197 of the initial 408 trial participants were included in this secondary analysis, of which 52% received IVT + EVT. SVS was present in 92% of the participants (n = 181). There was no evidence for treatment effect heterogeneity regarding the post-interventional radiological and clinical effects of IVT + EVT versus EVT alone with strata of SVS. In SVS+ participants, IVT favored pre-interventional reperfusion (aOR 7.95, 95% CI 1.42–44.46), whereas in SVS-patients, it did not (P for interaction = 0.02). The individual SVS characteristics showed no significant associations with outcomes.

Conclusion
Presence of SVS does not seem to modify the effect of IVT + EVT versus EVT alone. In SVS+ patients, IVT might improve pre-interventional reperfusion. There is insufficient evidence to recommend using SVS to inform IVT decisions prior to EVT.
Goodness-of-fit tests for discrete response models with covariates
Authors: Meintanis Simos G. , Ngatchou-Wandji Joseph , Santana Leonard , Smuts Marius 
Published: February 2025

Abstract
We propose goodness-of-fit tests for models of count responses with covariates. Our main focus is on the null hypothesis that the observed data come from a Poisson, a negative binomial, or a binomial regression model, but the method is fairly general allowing for the responses to follow, conditionally on covariates, any given discrete distribution. The test criteria are formulated by using the probability generating function and they are convenient from a computational point of view. Asymptotic as well as Monte Carlo results are presented. Applications on real data are also reported.
Determining the optimal hematoma volume-based thresholds for surgical and medical strategies in basal ganglia hemorrhage
Authors: Chaisawasthomrong Chonnawee , Boongird Atthaporn 
Published: February 2025

Abstract
Hematoma volume is a significant concern in basal ganglia hemorrhage, with no clear cutoff to guide the choice between conservative and surgical management, particularly for larger hematomas where the optimal approach remains controversial. This study aimed to determine the maximum hematoma volume suitable for conservative treatment and the volume that necessitates surgical intervention in patients with basal ganglia hemorrhage. A total of 387 cases of basal ganglia hemorrhage from 2019 to 2021 were analyzed, evaluating patient demographics, medical history, and initial CT brain scans to assess hematoma volume. Outcomes of medical and surgical treatments were compared using multivariate logistic and Cox regression analysis. For patients treated with medical management alone, mortality rates did not differ significantly between hematoma volumes of 10–39.9 mL and those under 10 mL. Receiver operating characteristic (ROC) curve analysis identified a cutoff volume of 45.3 mL, with a sensitivity of 80.82% and specificity of 91.67% for predicting survival. Kaplan–Meier survival analysis revealed a reduced mortality hazard ratio (0.17) with surgical intervention for hematomas exceeding 45.3 mL. However, surgical treatment for volumes under 30 mL was associated with higher mortality compared to medical management. Surgical intervention showed a clear survival benefit for hematoma volumes of at least 60 mL, while conservative treatment remained appropriate for volumes up to 45.3 mL. For volumes between 45.3 mL and 59.9 mL, the decision to operate should be guided by the surgeon’s judgment and patient-specific factors such as comorbidities, brain atrophy. In conclusion, conservative management is effective for hematomas up to 45.3 mL, while surgical intervention is absolutely indicated for volumes of 60 mL or more. These findings provide valuable guidance for optimizing treatment strategies in basal ganglia hemorrhage.