bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electronic Data Capture System (REDCap) for Health Care Research and Training in a Resource-Constrained Environment: Technology Adoption Case Study
Authors: Maré Irma Adele , Kramer Beverley , Hazelhurst Scott , Nhlapho Mapule Dorcus , Zent Roy , Harris Paul A , Klipin Michael 
Published: May 2022

Background
Electronic data capture (EDC) in academic health care organizations provides an opportunity for the management, aggregation, and secondary use of research and clinical data. It is especially important in resource-constrained environments such as the South African public health care sector, where paper records are still the main form of clinical record keeping.

Objective
The aim of this study was to describe the strategies followed by the University of the Witwatersrand Faculty of Health Sciences (Wits FHS) during the period from 2013 to 2021 to overcome resistance to, and encourage the adoption of, the REDCap (Research Electronic Data Capture; Vanderbilt University) system by academic and clinical staff. REDCap has found wide use in varying domains, including clinical studies and research projects as well as administrative, financial, and human resource applications. Given REDCap’s global footprint in >5000 institutions worldwide and potential for future growth, the strategies followed by the Wits FHS to support users and encourage adoption may be of importance to others using the system, particularly in resource-constrained settings.

Methods
The strategies to support users and encourage adoption included top-down organizational support; secure and reliable application, hosting infrastructure, and systems administration; an enabling and accessible REDCap support team; regular hands-on training workshops covering REDCap project setup and data collection instrument design techniques; annual local symposia to promote networking and awareness of all the latest software features and best practices for using them; participation in REDCap Consortium activities; and regular and ongoing mentorship from members of the Vanderbilt University Medical Center.

Results
During the period from 2013 to 2021, the use of the REDCap EDC system by individuals at the Wits FHS increased, respectively, from 129 active user accounts to 3447 active user accounts. The number of REDCap projects increased from 149 in 2013 to 12,865 in 2021. REDCap at Wits also supported various publications and research outputs, including journal articles and postgraduate monographs. As of 2020, a total of 233 journal articles and 87 postgraduate monographs acknowledged the use of the Wits REDCap system.

Conclusions
By providing reliable infrastructure and accessible support resources, we were able to successfully implement and grow the REDCap EDC system at the Wits FHS and its associated academic medical centers. We believe that the increase in the use of REDCap was driven by offering a dependable, secure service with a strong end-user training and support model. This model may be applied by other academic and health care organizations in resource-constrained environments planning to implement EDC technology.
Implementation of Smartphone Systems to Improve Quality of Life for People With Substance Use Disorder: Interim Report on a Randomized Controlled Trial
Authors: Gustafson Sr David , Horst Julie , Boss Deanne , Fleddermann Kathryn , Jacobson Nora , Roosa Mathew , Ross J Charles , Gicquelais Rachel , Vjorn Olivia , Siegler Tracy , Molfenter Todd 
Published: May 2022

Background
Researchers have conducted numerous studies seeking to understand how to improve the implementation of changes in health care organizations, but less focus has been given to applying lessons already learned from implementation science. Finding innovative ways to apply these findings efficiently and consistently will improve current research on implementation strategies and allow organizations utilizing these techniques to make changes more effectively.

Objective
This research aims to compare a practical implementation approach that uses principles from prior implementation studies to more traditional ways of implementing change.

Methods
A total of 43 addiction treatment sites in Iowa were randomly assigned to 2 different implementation strategies in a randomized comparative effectiveness trial studying the implementation of an eHealth substance use disorder treatment technology. One strategy used an adaptation of the Network for the Improvement of Addiction Treatment (NIATx) improvement approach, while the other used a traditional product training model. This paper discusses lessons learned about implementation.

Results
This midterm report indicates that use of the NIATx approach appears to be leading to improved outcomes on several measures, including initial and sustained use of new technology by both counselors and patients. Additionally, this research indicates that seamlessly integrating organizational changes into existing workflows and using coaching to overcome hurdles and assess progress are important to improve implementation projects.

Conclusions
At this interim point in the study, it appears that the use of the NIATx improvement process leads to better outcomes in implementation of changes within health care organizations. Moreover, some strategies used in this improvement process are particularly useful and should be drawn on more heavily in future implementation efforts.

Trial Registration
ClinicalTrials.gov NCT03954184; https://clinicaltrials.gov/ct2/show/NCT03954184
The Effect of Fear of Infection and Sufficient Vaccine Reservation Information on Rapid COVID-19 Vaccination in Japan: Evidence From a Retrospective Twitter Analysis
Authors: Niu Qian , Liu Junyu , Kato Masaya , Nagai-Tanima Momoko , Aoyama Tomoki 
Published: May 2022

Background
The global public health and socioeconomic impacts of the COVID-19 pandemic have been substantial, rendering herd immunity by COVID-19 vaccination an important factor for protecting people and retrieving the economy. Among all the countries, Japan became one of the countries with the highest COVID-19 vaccination rates in several months, although vaccine confidence in Japan is the lowest worldwide.

Objective
We attempted to find the reasons for rapid COVID-19 vaccination in Japan given its lowest vaccine confidence levels worldwide, through Twitter analysis.

Methods
We downloaded COVID-19–related Japanese tweets from a large-scale public COVID-19 Twitter chatter data set within the timeline of February 1 and September 30, 2021. The daily number of vaccination cases was collected from the official website of the Prime Minister’s Office of Japan. After preprocessing, we applied unigram and bigram token analysis and then calculated the cross-correlation and Pearson correlation coefficient (r) between the term frequency and daily vaccination cases. We then identified vaccine sentiments and emotions of tweets and used the topic modeling to look deeper into the dominant emotions.

Results
We selected 190,697 vaccine-related tweets after filtering. Through n-gram token analysis, we discovered the top unigrams and bigrams over the whole period. In all the combinations of the top 6 unigrams, tweets with both keywords “reserve” and “venue” showed the largest correlation with daily vaccination cases (r=0.912; P<.001). On sentiment analysis, negative sentiment overwhelmed positive sentiment, and fear was the dominant emotion across the period. For the latent Dirichlet allocation model on tweets with fear emotion, the two topics were identified as “infect” and “vaccine confidence.” The expectation of the number of tweets generated from topic “infect” was larger than that generated from topic “vaccine confidence.”

Conclusions
Our work indicates that awareness of the danger of COVID-19 might increase the willingness to get vaccinated. With a sufficient vaccine supply, effective delivery of vaccine reservation information may be an important factor for people to get vaccinated. We did not find evidence for increased vaccine confidence in Japan during the period of our study. We recommend policy makers to share accurate and prompt information about the infectious diseases and vaccination and to make efforts on smoother delivery of vaccine reservation information.
Variation in Peritoneal Dialysis Time on Therapy by Country
Authors: Lambie Mark , Zhao Junhui , McCullough Keith , Davies Simon J. , Kawanishi Hideki , Johnson David W. , Sloand James A. , Sanabria Mauricio , Kanjanabuch Talerngsak , Kim Yong-Lim , Shen Jenny I. , Pisoni Ronald L. , Robinson Bruce M. , Perl Jeffrey ,   the PDOPPS Steering Committee
Published: May 2022

Background and objectives
Quantifying contemporary peritoneal dialysis time on therapy is important for patients and providers. We describe time on peritoneal dialysis in the context of outcomes of hemodialysis transfer, death, and kidney transplantation on the basis of the multinational, observational Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) from 2014 to 2017.

Design, setting, participants, & measurements
Among 218 randomly selected peritoneal dialysis facilities (7121 patients) in the PDOPPS from Australia/New Zealand, Canada, Japan, Thailand, the United Kingdom, and the United States, we calculated the cumulative incidence from peritoneal dialysis start to hemodialysis transfer, death, or kidney transplantation over 5 years and adjusted hazard ratios for patient and facility factors associated with death and hemodialysis transfer.

Results
Median time on peritoneal dialysis ranged from 1.7 (interquartile range, 0.8–2.9; the United Kingdom) to 3.2 (interquartile range, 1.5–6.0; Japan) years and was longer with lower kidney transplantation rates (range: 32% [the United Kingdom] to 2% [Japan and Thailand] over 3 years). Adjusted hemodialysis transfer risk was lowest in Thailand, but death risk was higher in Thailand and the United States compared with most countries. Infection was the leading cause of hemodialysis transfer, with higher hemodialysis transfer risks seen in patients having psychiatric disorder history or elevated body mass index. The proportion of patients with total weekly Kt/V ≥1.7 at a facility was not associated with death or hemodialysis transfer.

Conclusions
Countries in the PDOPPS with higher rates of kidney transplantation tended to have shorter median times on peritoneal dialysis. Identification of infection as a leading cause of hemodialysis transfer and patient and facility factors associated with the risk of hemodialysis transfer can facilitate interventions to reduce these events.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2022_05_31_CJN16341221.mp3
Validez y confiabilidad de la Escala Breve de Resiliencia Connor-Davidson (CD-RISC 10) en estudiantes universitarios de Lima Metropolitana
Authors: Bernaola Ugarte Alejandro David , Garcia Garcia Miguel , Martinez Campos Noemi , Ocampos Madrid Marks , Livia José 
Published: May 2022

La investigación tuvo como propósito analizar las propiedades psicométricas de la Escala Breve de Resiliencia Connor-Davidson (CD-RISC 10). La muestra constó de 345 universitarios de ambos sexos de una universidad privada, con edades comprendidas entre los 18 a 50 años provenientes de Lima Metropolitana (Perú). Los instrumentos utilizados fueron la escala breve de resiliencia CD-RISC 10, la Escala de Estrés Percibido (EEP-10) y la Escala de Autoeficacia General (EAG). Para analizar la validez de constructo se realizó un análisis factorial que demostró que el modelo unifactorial explica el 47 % la varianza total acumulada, posteriormente se pasó a corroborar el modelo propuesto a través del análisis factorial confirmatorio que arrojó valores óptimos de ajuste. Se estudió la validez convergente con las variables autoeficacia general (r = .664, p = .000) y una validez divergente con estrés percibido (r = -.402, p = .000). La confiabilidad se estableció a través de los coeficientes de alfa de Cronbach (α = .827) y Omega de McDonald (Ω = .827). Los resultados permiten concluir que el instrumento presenta evidencias de validez y que sus puntuaciones son consistentes.
10-OR: Combination Therapy with Anti-CD3 Antibody and Harmine plus Exendin-4 Enhances Remission from Recent-Onset Type 1 Diabetes.
Authors: LU GEMING , KANG RANDY , LI YANSUI , WANG PENG , ROSSELOT CAROLINA , DEVITA ROBERT J. , STEWART ANDREW F. , GARCIA-OCANA ADOLFO 
Published: May 2022

Type 1 diabetes (T1D) results from loss of both immune tolerance and functional β-cells. Administration of harmine (H) plus exendin-4 (E) markedly induces human β-cell expansion. Anti-CD3 antibody treatment reduces C-peptide loss in T1D patients. Here, we tested whether combination therapy with anti-CD3 antibody and H+E enhances T1D remission in non-obese diabetic (NOD) mice. First, we tested whether H+E protects human β-cells against inflammation and ER stress. We found that H+E, but not the drugs alone, significantly reduced both thapsigargin- and cytokine-induced human β-cell apoptosis. Single-cell RNAseq of human islets treated with cytokines and H+E showed reduced IL1β and IFNγ signaling in β-cells. Apoptosis genes such as CYLD and RIPK1 were downregulated and prosurvival genes such as HIF1A and VEGFA were upregulated in β-cells of H+E-treated islets. Next, treatment of early-onset diabetic NOD mice with H+E (daily ip) for 8 weeks improved glucose homeostasis but failed to induce long-lasting immune tolerance and T1D remission. Therefore, we next treated early-onset diabetic NOD mice with low-dose anti-CD3 antibody daily for 3 days (40µg/day) followed by 8 weeks treatment with H+E or vehicle (V) (Alzet pumps) . Treatment with anti-CD3 and H+E eliminated hyperglycemia in 100% of the mice vs. only 20% remission in anti-CD3 and V-treated mice. CD3+ T cell numbers were significantly and similarly reduced (∼50%) in mice treated with H+E or V. Preliminary results indicate that activated T cells in pancreatic lymph nodes (PLNs) and islet insulitis were significantly reduced, and T regulatory cells in spleen and PLNs were increased in H+E-treated mice. TUNEL+ β-cells were decreased and Ki67+ β-cells were increased in the pancreas of H+E-treated mice. Collectively, these results indicate that combination therapy with low-dose anti-CD3 antibody and H+E enhances T1D remission in diabetic NOD mice by increasing β-cell viability and favoring immune tolerance.

Disclosure
G.Lu: None. R.Kang: None. Y.Li: None. P.Wang: None. C.Rosselot: None. R.J.Devita: None. A.F.Stewart: None. A.Garcia-ocana: Consultant; Sun Pharmaceutical Industries Ltd.

Funding
NIH DK105015
1064-P: Use of the inControl Algorithm for Automated Insulin Delivery during Childbirth: A Case Series
Authors: DONOVAN LOIS E. , MCKEEN JULIE , FEIG DENICE 
Published: May 2022

Background: Automated Insulin Delivery systems (AIDs) can improve glucose control in people with type 1 diabetes but study of their use during childbirth is limited. Some commercially available AIDs use the inControl algorithm (iCa) to automate insulin dosing. Tight glycemic control during labor and childbirth is believed to reduce the risk of neonatal hypoglycemia. Immediately postpartum insulin resistance drops leading to large reductions in insulin requirements.
Aim: To examine the performance of the iCa at time of childbirth and develop guidance for pump setting adjustments to maintain euglycemia during labor and childbirth and to prevent hypoglycemia postpartum. Cases: Five women chose to use iCa during childbirth. Two had scheduled caesarean births (CS) . One had a CS after a failed induction of labour. Two had vaginal births. All switched to lower basal rates (at least two-thirds less than their prepregnancy dose) and higher insulin sensitivity factors at least 1 hour prior to childbirth. Sleep activity (SA) was maintained prior to and during CS. Those with vaginal births switched from SA to exercise activity (EA) at time of pushing. iCa stops insulin delivery when glucose is predicted to go below 70 mmol/L in SA or 80 mmol/L in EA in the next 30 minutes.
Results: Hypoglycemia during childbirth and early postpartum was avoided in all five cases despite substantial reduction in insulin need following childbirth. Glucose levels increased after the insulin adjustments were made prior to childbirth, but rose especially after childbirth. There were larger glucose increments among those who changed from SA to EA.
Conclusion: Early adopters of iCa safely used iCa during childbirth. Precautionary reductions in insulin doses made prior to childbirth prevented hypoglycemia at time of childbirth and early postpartum. Mild hyperglycemia resulted in some. Further study is required to assess if these precautionary pump setting adjustments are necessary during labor and childbirth when using the iCa.

Disclosure
L.E.Donovan: Other Relationship; Dexcom, Inc., Inner Analytics, Medtronic, Tandem Diabetes Care, Inc. J.Mckeen: None. D.Feig: Advisory Panel; Novo Nordisk, Research Support; Apotex.
1073-P: Accelerometer-Derived Movement Patterns in Older People with Diabetes and Varying Functional Status
Authors: YAHALOM-PERI TAL , KODESH EINAT , BASSON-SHLEYMOVICH YAMIT , AZMON MICHAL , BOGINA VERONIKA , KUFLIK TSVI , CUKIERMAN-YAFFE TALI 
Published: May 2022

Introduction: Type 2 Diabetes (T2D) is associated with reduced muscle mass, strength and function leading to frailty and disability. Little is known regarding the continuous movement patterns and glucose fluctuation in these functional states. Aims: To identify differences in movement patterns and glucose levels in elderly people with diabetes with ranging functional status.
Methods: We conducted a cross sectional study, amongst people with diabetes over the age of 60. Participants were provided with a blinded Continuous Glucose Monitoring (CGM) system (iPro™ professional CGM, Medtronic) and an activity monitoring device (ActiGraph® GT9X) for 1 week. In order to evaluate their physical functionality, participants underwent elaborate physical-function (PF) tests which were conducted in the beginning and at the end of the week. Participants (n=103) were classified into 3 groups: Low PF (LPF; n=20) , reduced PF (RPF; n=37) and normal PF (NPF; n=46) by using the Fried frailty scale; aerobic, strength and balance score. Movement and glucose indices differences between the groups were determined using Kruskal-Wallis and Dunn post-hoc statistical tests.
Results: LPF group had lower average X (Medio-lateral - side to side) and Y (Vertical - up down) axes movements and higher variability expressed by root mean square of the X, Y, Z (Antero-posterior - forwards backwards) axes. In addition, LPF group spent less time performing moderate to vigorous physical activity and had fewer daily steps compared to RPF and NPF groups. CGM data revealed that the LPF group had higher mean glucose levels and they spent less time in target glucose range (70-180 mg/dl) and more time above range (&gt;180 mg/dl) compared to the other groups. All findings were statistically significant (p&lt;0.05) .
Conclusion: In this study of older people with diabetes, participants in the LPF group demonstrated lower stability, lower activity levels and higher glucose rates compared to those in the NPF group.

Disclosure
T.Yahalom-peri: None. E.Kodesh: None. Y.Basson-shleymovich: None. M.Azmon: n/a. V.Bogina: None. T.Kuflik: None. T.Cukierman-yaffe: Research Support; European Association for the Study of Diabetes, Medtronic, Merck Sharp & Dohme Corp., Novo Nordisk, Speaker's Bureau; AstraZeneca, Eli Lilly and Company, Medtronic, Merck Sharp & Dohme Corp., Novo Nordisk, Sanofi.

Funding
EFSD & an Investigator Initiated Study Medtronic
1085-P: Exploring Racial and Ethnic Disparities in Arterial Stiffness in Type 1 Diabetes
Authors: SAUDER KATHERINE A. , GLUECK DEBORAH H. , HARRALL KYLIE K. , DAGOSTINO RALPH , DOLAN LAWRENCE M. , LANE-CORDOVA ABBI , LIESE ANGELA D. , LUSTIGOVA EVA , MALIK FAISAL , MARCOVINA SANTICA M. , MAYER-DAVIS ELIZABETH J. , MOTTL AMY K. , PIHOKER CATHERINE , REYNOLDS KRISTI , SHAH AMY S. , URBINA ELAINE M. , WAGENKNECHT LYNNE E. , DANIELS STEPHEN R. , DABELEA DANA 
Published: May 2022

We studied arterial stiffness in youth and young adults with T1D and potential longitudinal mediators of racial and ethnic disparities. SEARCH for Diabetes in Youth Study participants (n=2317; 14% Hispanic, 12% non-Hispanic Black, 74% non-Hispanic White) had CV risk factors (body size, lipid profile, blood pressure, A1c, urinary creatinine, pulse) measured 2-6 times from ∼9 months up to ˜years after T1D diagnosis. Arterial stiffness was measured with pulse wave velocity (PWV) at ˜years T1D duration (˜18 years of age) . For each risk factor, we summarized the longitudinal data as mean, max, slope, and area-under-the-curve (AUC) . Using split test/replication datasets, we a) identified the summary statistic for each risk factor most associated with PWV using flipped multivariate general linear models, and b) used the resulting statistics to construct a risk score predicting PWV with a stepwise general linear model. The final score included AUC for BMI, triglycerides and creatinine; heart rate slope; max mean arterial pressure; and age and T1D duration at PWV measurement, explaining 35% of variability in PWV at 18 years. PWV varied by race and ethnicity (Figure - left) . Adjustment for the risk score partially attenuated this disparity (Figure - right) . These data suggest CV risk factors from T1D diagnosis onward are related to racial and ethnic disparities in arterial stiffness, but other factors are likely involved.

Disclosure
K.A.Sauder: None. S.M.Marcovina: None. E.J.Mayer-davis: None. A.K.Mottl: Advisory Panel; Bayer AG, Board Member; Bayer AG, Research Support; Alexion Pharmaceuticals, Inc., Aurinia, Bayer AG, Boehringer Ingelheim International GmbH, Pfizer Inc. C.Pihoker: None. K.Reynolds: Research Support; Amgen Inc., Merck & Co., Inc., Novartis Pharmaceuticals Corporation. A.S.Shah: None. E.M.Urbina: Advisory Panel; Astellas Pharma Inc. L.E.Wagenknecht: None. S.R.Daniels: None. D.Dabelea: None. D.H.Glueck: None. K.K.Harrall: None. R.Dagostino: Consultant; Aetion, Inc., AstraZeneca, Biogen, Bristol-Myers Squibb Company, Daiichi Sankyo, Merck & Co., Inc. L.M.Dolan: None. A.Lane-cordova: None. A.D.Liese: None. E.Lustigova: None. F.Malik: n/a.

Funding
National Institutes of Health
1088-P: Racial, Socioeconomic, and Geographical Disparities in Cardiovascular Disease (CVD) among Medicare Beneficiaries with Diabetes (DM)
Authors: PARK JOOHYUN , ZHOU XILIN , ZHANG PING 
Published: May 2022

Despite a high prevalence of DM and CVD in older adults in the US, relatively little is known about how CVD prevalence varies by sociodemographic factors in older adults with DM. Using the 2017-20Medicare Current Beneficiaries Survey, we examined the prevalence of self-reported myocardial infarction (MI) , heart failure (HF) , and stroke by race/ethnicity (non-Hispanic White, non-Hispanic Black, Hispanic, and others) , poverty (income-to-poverty ratio: ≤100%, &lt;100%─≤120%, &lt;120%─≤135%, &lt;135%─≤200%, and &gt;200%) , educational level (&lt;high school, high school graduate, and &gt;high school) , and urbanicity of residence among Medicare beneficiaries with DM aged ≥65 years. We estimated weighted adjusted prevalence of CVDs using multivariable logistic regression, controlling for age and sex. Compared to non-Hispanic White persons, non-Hispanic Black persons had a higher prevalence of HF and Hispanic persons had a lower prevalence (Figure) ; rural residents had a higher prevalence of MI, HF, and stroke than urban residents; the lowest income group (≤100%) had a higher prevalence of MI, HF, and stroke than the highest income group (&gt;200%) ; and those with &lt;high school had a higher prevalence of MI and stroke than those with &gt;high school education (P&lt;0.for all) . CVDs disproportionately affected older adults with DM who live in rural areas and have lower socioeconomic status.

Disclosure
J.Park: None. X.Zhou: None. P.Zhang: None.