bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Kualitas Sistem Informasi Akuntansi, Kecanggihan Teknologi Informasi, dan Kinerja Individual terhadap Efektivitas Sistem Informasi Akuntansi pada BPR Arta Bangsal Utama Mojokerto
Authors: Alful laili Alful , Seno Aji Tony 
Published: June 2022

This study aims to determine the effect of the quality of accounting information systems, sophistication of information technology, and individual performance on the effectiveness of accounting information systems at BPR Arta Bangsal Utama Mojokerto. The sampling techniqueyin this study used purposive sampling with a total of 40 respondents. The analysis technique used is the validity test technique, reliability test, classical assumption test, multiple linear regression analysis, hypothesis testing. The results of this study indicate that (1) the quality of the accounting information system has a significant effect on the effectiveness of the accounting information system which indicates that the higher the quality of the accounting information system, the more it affects the effectiveness of the accounting information system of BPR Arta Bangsal Utama Mojokerto. (2) the sophistication of information technology has alsignificant effect on the effectiveness of the accounting information system which shows that the higher the accounting information technology, the more it will affect the effectiveness of the accounting information system of BPR Arta Bangsal Utama Mojokerto. (3) individual performance has a significant effect on the effectiveness of the accounting information system, which indicates that the higher the individual performance, the more it affects the effectiveness of the accounting information system for BPR Arta Bangsal Mojokerto.
Keywords: Quality of accounting information systems; Sophistication of accounting information technology, Individual performance; Effectiveness of accounting information systems.
Pengaruh Sistem Informasi Akuntansi Dan Sistem Pengendalian Internal Terhadap Upaya Pencegahan Fraud Pada Persediaan (Studi Kasus Pada PT. Catur Sentosa Adiprana TBK Cabang Kediri)
Authors: Syah Pahlevi Reza , Ari Pertiwi Dwi 
Published: June 2022

Implementasi SAP Era globalisasi saat ini membuat semakin berkembangnya kegiatan usaha dalam berbagai sektor perekonomian, terutama di bidang penjualan barang yang bersifat fast moving. Semakin berkembangnya suatu usaha maka seorang pimpinan tidak memungkinkan untuk bisa mengawasi secara langsung kegiatan perusahaan dikarenakan adanya keterbatasan pengawasan sehingga tidak menutup kemungkinan terjadinya fraud dalam persediaan. Penelitian ini bertujuaan untuk mengetahui pengaruh: Sistem Informasi Akuntasi, Sistem Pengendalian Internal terhadap Upaya Pencegahan Fraud. Penelitian ini di lakukan di PT. Catur Sentosa Adiprana Tbk Cabang kediri dengan menggunakan data primer yaitu data dari kuisioner yang diisi oleh responden. Populasi dalam penelitian ini berjumlah 80 orang dan sampel yang dipakai berjumlah 67 orang. Teknik sampling yang digunakan adalah random sampling. Alat analisis yang digunakan adalahh ujikualitas data, uji asumsi klasik dan uji hipotesis dengan menggunakann bantuan aplikasi SPSS versi 25 untuk mengolah data. Hasil penelitian membuktikan bahwa variabel sistem informasi akutansi tidak mempunyai pengaruh terhadap upaya pencegahan fraud. Sedangkan variabel sistem pengendalian internal berpengaruh terhadap upaya pencegahan fraud.
Kata kunci: Sistem Informasi Akuntani, Sistem Pengendalian Interna, Fraud
Improved Multi-Stream Convolutional Block Attention Module for sEMG-Based Gesture Recognition
Authors: Wang Shudi , Huang Li , Jiang Du , Sun Ying , Jiang Guozhang , Li Jun , Zou Cejing , Fan Hanwen , Xie Yuanmin , Xiong Hegen , Chen Baojia 
Published: June 2022

As a key technology for the non-invasive human-machine interface that has received much attention in the industry and academia, surface EMG (sEMG) signals display great potential and advantages in the field of human-machine collaboration. Currently, gesture recognition based on sEMG signals suffers from inadequate feature extraction, difficulty in distinguishing similar gestures, and low accuracy of multi-gesture recognition. To solve these problems a new sEMG gesture recognition network called Multi-stream Convolutional Block Attention Module-Gate Recurrent Unit (MCBAM-GRU) is proposed, which is based on sEMG signals. The network is a multi-stream attention network formed by embedding a GRU module based on CBAM. Fusing sEMG and ACC signals further improves the accuracy of gesture action recognition. The experimental results show that the proposed method obtains excellent performance on dataset collected in this paper with the recognition accuracies of 94.1%, achieving advanced performance with accuracy of 89.7% on the Ninapro DB1 dataset. The system has high accuracy in classifying 52 kinds of different gestures, and the delay is less than 300 ms, showing excellent performance in terms of real-time human-computer interaction and flexibility of manipulator control.
Genetics of Base Coat Colour Variations and Coat Colour-Patterns of the South African Nguni Cattle Investigated Using High-Density SNP Genotypes
Authors: Kunene Langelihle Mbali , Muchadeyi Farai Catherine , Hadebe Khanyisile , Mészáros Gábor , Sölkner Johann , Dugmore Trevor , Dzomba Edgar Farai 
Published: June 2022

Nguni cattle are a Sanga type breed with mixed B. taurus and B. indicus ancestry and proven resistance to ticks, diseases and other harsh conditions of the African geographical landscape. The multi-coloured Nguni coats have found a niche market in the leather industry leading to breeding objectives towards the promotion of such diversity. However, there is limited studies on the genomic architecture underlying the coat colour and patterns hampering any potential breeding and improvement of such trait. This study investigated the genetics of base coat colour, colour-sidedness and the white forehead stripe in Nguni cattle using coat colour phenotyped Nguni cattle and Illumina Bovine HD (770K) genotypes. Base coat colour phenotypes were categorised into eumelanin (n = 45) and pheomelanin (n = 19). Animals were categorised into either colour-sided (n = 46) or non-colour-sided (n = 94) and similarly into presence (n = 15) or absence (n = 67) of white forehead stripe. Genome-wide association tests were conducted using 622,103 quality controlled SNPs and the Efficient Mixed Model Association eXpedited method (EMMAX) implemented in Golden Helix SNP Variation Suite. The genome-wide association studies for base coat colour (eumelanin vs. pheomelanin) resulted into four indicative SNPs on BTA18 and a well-known gene, MC1R, was observed within 1 MB from the indicative SNPs (p &lt; 0.00001) and found to play a role in the melanogenesis (core pathway for melanin production) and the MAPK signalling pathway. GWAS for colour-sidedness resulted in four indicative SNPs, none of which were in close proximity to the KIT candidate gene known for colour-sidedness. GWAS for the white forehead stripe resulted in 17 indicative SNPs on BTA6. Four genes MAPK10, EFNA5, PPP2R3C and PAK1 were found to be associated with the white forehead stripe and were part of the MAPK, adrenergic and Wnt signalling pathways that are synergistically associated with the synthesis of melanin. Overall, our results prove prior knowledge of the role of MC1R in base coat colours in cattle and suggested a different genetic mechanism for forehead stripe phenotypes in Nguni cattle.
Side Effects and Perceptions of COVID-19 Vaccination in Saudi Arabia: A Cross-Sectional Study
Authors: Al-Hanawi Mohammed Khaled , Keetile Mpho , Kadasah Nasser Akeil , Alshareef Noor , Qattan Ameerah M. N. , Alsharqi Omar 
Published: June 2022

BackgroundVaccination against any disease is critical in improving and maintaining public health. However, the overall effectiveness of a vaccine largely depends on the willingness of a population to receive it. The main aim of this study was to assess the side effects and perceptions about COVID-19 vaccines among adults following vaccination in Saudi Arabia.MethodsAn online cross-sectional survey was conducted from July 13 to July 20, 2021, among adults aged 18 years and older who had taken one or both doses of COVID-19 vaccines in Saudi Arabia. The survey included questions on socio-demographics, health behavior, vaccine type, knowledge about sources of information about COVID-19 vaccines, and perceptions and beliefs following vaccination. Bivariate and multivariable regression analyses were the major data analytic tools employed in the study.ResultsThe most common vaccine side effects reported were tiredness/fatigue (52.6%), swelling (38%), fever (31.3%), headache (29.1%), and muscle pain (22.2%). In multivariable analyses, the odds of experiencing severe side effects were significantly higher among males [adjusted odds ratio (aOR) = 2.76, 95% confidence interval (CI) = 1.71–4.45, p &lt; 0.01], those aged 40–49 years (aOR = 3.10, 95% CI = 1.10–8.72, p &lt; 0.1), and Saudi nationals (aOR = 3.64, 95% CI = 1.58–8.38, p &lt; 0.05) compared to their counterparts. The odds of believing that COVID-19 vaccines are safe in the long-term were significantly higher among men (aOR = 1.76, 95% CI = 1.16–2.65, p &lt; 0.01) and among individuals who had received two doses (aOR = 1.62, 95% CI = 1.09–2.40, p &lt; 0.05), and the odds of advising others to get vaccinated for COVID-19 were also significantly higher among respondents who had received two doses (aOR = 2.81, 95% CI = 1.60–4.93, p &lt; 0.01) compared to their counterparts.ConclusionThis study identified the most common COVID-19 vaccine side effects in Saudi Arabia, therefore making them predictable. This information will help reduce vaccine hesitancy as booster doses become available.
Peking Prognostic Score, Based on Preoperative Sarcopenia Status, Is a Novel Prognostic Factor in Patients With Gastric Cancer
Authors: Xiong Jianping , Hu Haitao , Kang Wenzhe , Li Yang , Jin Peng , Shao Xinxin , Li Weikun , Tian Yantao 
Published: June 2022

BackgroundThis study focused on assessing the role of the Peking prognostic score (PPS), a novel prognostic index based on muscle atrophy and lymphocyte-to-C-reactive protein ratio, within gastric cancer patient prognosis.MethodsWe analyzed the data collected from 774 gastric cancer cases between April 2011 and February 2016 (discovery cohort). The results were assessed in 575 gastric cancer cases from March 2016 to September 2019 (validation cohort). For evaluating skeletal muscle mass, we obtained computed tomography images at the third lumbar vertebra level (L3). We performed a time-dependent receiver operating characteristic curve (t-ROC) to analyze PPS’s prognostic significance with others.ResultsThe discovery cohort enrolled altogether 774 patients with non-metastatic gastric cancer, including 639 (82.5%) men along with 135 (17.5%) women. The patients were divided into 3 groups; 166 patients (21.4%) were assigned into group 0, 472 (60.9%) in group 1, and 136 (17.7%) in group 2, respectively. An increased PPS was in direct proportion to an elder age, reduced body mass index, higher Pathological Tumor Lymph Node Metastasis stage, perineural invasion, and vascular invasion. We identified PPS to independently estimate patient overall survival (OS) together with disease-free survival (DFS; both P &lt; 0.001). Additionally, as revealed by t-ROC analysis, PPS exhibited the highest sensitivity compared with other prognostic scoring systems in predicting patient survival. Finally, we evaluated the prognostic value of PPS in the validation cohort and confirmed that preoperative PPS independently estimates patient OS and DFS.ConclusionThe PPS accounts for an efficient nutrition-inflammation prognostic scoring system in gastric cancer patients.
Gross Tumor Volume Predicts Survival and Pathological Complete Response of Locally Advanced Esophageal Cancer After Neoadjuvant Chemoradiotherapy
Authors: Wang Rong , Zhou Xiaomei , Liu Tongxin , Lin Shuimiao , Wang Yanxia , Deng Xiaogang , Wang Wei 
Published: June 2022

BackgroundNeoadjuvant chemoradiotherapy (neo-CRT) plus surgery has greatly improved the prognosis of locally advanced esophageal cancer (EC) patients. But which factors may influence the pathological tumor response and long-term survival remains unclear. The purpose of this study was to identify the prognostic biomarkers of locally advanced EC patients receiving neo-CRT.MethodsWe reviewed the data of 72 patients with cT2-4N0-3M0 EC who underwent neo-CRT at our hospital. The patients received intensity-modulated radiation therapy with a total radiation dose of 41.4–60.0 Gy. Most patients received platinum + paclitaxel-based combination regimens every three weeks for 2–4 cycles. The recorded data included age, sex, smoking history, alcohol use, histology, tumor location, clinical TNM stage, tumor length, gross tumor volume (GTV), GTV of primary tumor (GTVp), GTV of lymph nodes (GTVn), radiation dose, and number of chemotherapy cycles. Overall survival (OS), progression-free survival (PFS), and pathological complete response (pCR) were analyzed.ResultsThe 3-year OS and PFS rates of these patients who underwent neo-CRT were 51.14% and 43.28%, respectively. In the univariate analyses, smoking history, clinical stage, GTV, GTVp, and GTVn were significantly associated with OS, whereas alcohol use, GTV, GTVp, and GTVn were significantly associated with PFS. Furthermore, in the multivariate analysis, GTV was an independent prognostic predictor of OS (hazard ratio (HR): 14.14, 95% confidence interval (CI): 3.747–53.33, P &lt; 0.0001) and PFS (HR: 6.090, 95% CI: 2.398–15.47, P &lt; 0.0001). In addition, GTV &lt; 60.50 cm3 compared to &gt; 60.50 cm3 was significantly associated with higher pCR rate (59.3% and 27.8%, respectively, P = 0.038). High dose (&gt; 50 Gy) and increased number of chemotherapy cycles (≥ 3) didn’t improve the OS or PFS in patients with GTV &gt; 60.50 cm3.ConclusionGTV was an independent prognostic factor of long-term survival in EC patients, which may be because GTV is associated with histological response to neo-CRT. Additionally, patients with GTV &gt; 60.50 cm3 didn’t benefit from increased radiation dose or increased number of chemotherapy cycles.
Serum and Serum Exosomal CircRNAs hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 as Diagnostic Biomarkers for Lung Adenocarcinoma
Authors: Kang Yanli , You Jianbin , Gan Yuhan , Chen Qianshun , Huang Chen , Chen Falin , Xu Xunyu , Chen Liangyuan 
Published: June 2022

BackgroundCircular RNAs (circRNAs) play an important role in tumorigenesis and several circulating circRNA signatures are closely associated with tumor diagnosis. However, the expression and clinical significance of the two forms of circulating circRNAs, serum and serum exosomal, in patients with lung adenocarcinoma (LUAD), have not been characterized.MethodsThree differentially expressed exosomal circRNAs, hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896, were selected based on previous exosomal circRNA sequencing data analyses of LUAD patients. The expression of these circRNAs in serum and serum-derived exosomes of LUAD patients was assessed using quantitative real-time PCR (qRT-PCR), and correlations between circRNA expression and clinicopathological characteristics were analyzed. The reliability of serum and serum exosomal hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 to diagnose LUAD was evaluated using receiver operating characteristic (ROC) analysis.ResultsExpression of serum and serum exosomal hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 were significantly higher in LUAD patients than in healthy donors, and significantly lower after surgery. These three serum exosomal circRNAs were also associated with a higher cancer stage. Exosomal hsa_circ_0001492 expression was positively correlated with carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) levels. An association between the expression of the three serum circRNAs and clinical characteristics was not observed. In addition, the three serum exosomal circRNAs had higher diagnostic sensitivity and specificity than the serum circRNAs, and the area under the curve (AUC) of all three serum exosomal circRNAs was &gt;0.75. The combination of exosomal hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 had better diagnostic sensitivity and specificity than that of a single marker, with an AUC value of 0.805.ConclusionsThe serum and serum exosomal circRNAs, hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896, were upregulated in LUAD patients. Serum exosomal circRNAs may serve as more effective biomarkers than serum circRNAs for LUAD diagnosis and may further aid the detection of this disease.
Antifibrotic Mechanism of Piceatannol in Bleomycin-Induced Pulmonary Fibrosis in Mice
Authors: Sheng Hanjing , Lin Gang , Zhao Shengxian , Li Weibin , Zhang Zhaolin , Zhang Weidong , Yun Li , Yan Xiaoyang , Hu Hongyu 
Published: June 2022

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease characterized by myofibroblast accumulation and extracellular matrix deposition, which lead to irreversible damage of the lung’s architecture and the formation of fibrotic lesions. IPF is also a sequela in serious patients with the coronavirus disease 2019 (COVID-19). The molecular mechanisms under pulmonary fibrosis remain unclear, and there is no satisfactory treatment currently available. Piceatannol (PIC) is a naturally occurring resveratrol analog found in a variety of dietary sources such as grapes, passion fruit, and white tea. It has been reported to inhibit liver fibroblast growth and exhibited various antitumor activities, although its role in pulmonary fibrosis has not been established yet. In the present study, we evaluated the anti-fibrotic role of PIC in bleomycin (BLM)-induced pulmonary fibrosis in mice.Methods: Mice with BLM-induced pulmonary fibrosis were treated with PIC, and fibrotic changes were measured by hematoxylin-eosin (H&amp;E) staining and hydroxyproline assay. Luciferase assay, Western blot assay, histological analysis, and immunofluorescence staining were used to evaluate the effect of PIC on fibroblast activation and autophagy in mouse embryonic fibroblast cells (NIH-3T3) and human lung fibroblast cells (HFL1). The anti-fibrotic mechanisms of PIC were either confirmed in vivo.Results: Our results showed that PIC significantly alleviated the bleomycin-induced collagen deposition and myofibroblast accumulation. In vitro and in vivo studies indicated that PIC plays a role in activating autophagy in the process of anti-fibroblast activation. Further mechanism studies demonstrated that PIC can promote autophagy via inhibiting the TGF-β1-Smad3/ERK/P38 signaling pathway, which leads to a decreased number of activated myofibroblasts.Conclusion: Our study demonstrated for the first time that PIC possesses the protective effects against bleomycin-induced pulmonary fibrosis due to the direct pulmonary protective effects which enhance the effect of autophagy in vitro and in vivo and finally leads to the decreased number of activated myofibroblasts. PIC may serve as a candidate compound for pulmonary fibrosis therapy and attenuates the sequelae of SARS-COV-2 pulmonary fibrosis.
Oral Co-Supplementation of Curcumin, Quercetin, and Vitamin D3 as an Adjuvant Therapy for Mild to Moderate Symptoms of COVID-19—Results From a Pilot Open-Label, Randomized Controlled Trial
Authors: Khan Amjad , Iqtadar Somia , Mumtaz Sami Ullah , Heinrich Michael , Pascual-Figal Domingo A. , Livingstone Shona , Abaidullah Sajid 
Published: June 2022

Background:Curcumin, quercetin, and vitamin D3 (cholecalciferol) are common natural ingredients of human nutrition and reportedly exhibit promising anti-inflammatory, immunomodulatory, broad-spectrum antiviral, and antioxidant activities.Objective:The present study aimed to investigate the possible therapeutic benefits of a single oral formulation containing supplements curcumin, quercetin, and cholecalciferol (combinedly referred to here as CQC) as an adjuvant therapy for early-stage of symptomatic coronavirus disease 2019 (COVID-19) in a pilot open-label, randomized controlled trial conducted at Mayo Hospital, King Edward Medical University, Lahore, Pakistan.Methods:Reverse transcriptase polymerase chain reaction (RT-PCR) confirmed, mild to moderate symptomatic COVID-19 outpatients were randomized to receive either the standard of care (SOC) (n= 25) (control arm) or a daily oral co-supplementation of 168 mg curcumin, 260 mg quercetin, and 9 µg (360 IU) of cholecalciferol, as two oral soft capsules b.i.d. as an add-on to the SOC (n= 25) (CQC arm) for 14 days. The SOC includes paracetamol with or without antibiotic (azithromycin). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR test, acute symptoms, and biochemistry including C-reactive protein (CRP), D-dimer, lactate dehydrogenase, ferritin, and complete blood count were evaluated at baseline and follow-up day seven.Results:Patients who received the CQC adjuvant therapy showed expedited negativization of the SARS-CoV-2 RT-PCR test, i.e., 15 (60.0%) vs. five (20.0%) of the control arm,p= 0.009. COVID-19- associated acute symptoms were rapidly resolved in the CQC arm, i.e., 15 (60.0%) vs. 10 (40.0%) of the control arm,p= 0.154. Patients in the CQC arm experienced a greater fall in serum CRP levels, i.e., from (median (IQR) 34.0 (21.0, 45.0) to 11.0 (5.0, 16.0) mg/dl as compared to the control arm, i.e., from 36.0 (28.0, 47.0) to 22.0 (15.0, 25.0) mg/dl,p= 0.006. The adjuvant therapy of co-supplementation of CQC was safe and well-tolerated by all 25 patients and no treatment-emergent effects, complications, side effects, or serious adverse events were reported.Conclusion:The co-supplementation of CQC may possibly have a therapeutic role in the early stage of COVID-19 infection including speedy negativization of the SARS-CoV-2 RT-PCR test, resolution of acute symptoms, and modulation of the hyperinflammatory response. In combination with routine care, the adjuvant co-supplementation of CQC may possibly help in the speedy recovery from early-stage mild to moderate symptoms of COVID-19. Further research is warranted.Clinical Trial Registration:Clinicaltrials.gov, identifier NCT05130671