bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of Assets and Follow-Up the Findings of the Audit Board to Increase Financial Performance of Local Governments
Authors: Yamin Ridha , Mas'ud Masdar , Sjarlis Sylvia 
Published: April 2022

The dependence of most local governments on the central government in funding regional spending is still a problem in Indonesia. Although the regional autonomy system has been implemented, including in terms of regional financial management, local governments still have difficulty in implementing efficient regional spending. This effort is done so that the financial management of local governments can be implemented efficiently. This research aims to find out the impact of the size of local governments, audit findings and follow-up of the recommendations of The Audit Board of the Republic of Indonesia on the financial performance of local governments This study uses a quantitative approach by testing hypotheses using multiple regression analysis methods in cross sectional data. The study used data from local government performance reports in 2019. The study analyses 406 district/city governments report in Indonesia. The results showed that: 1) There is a positive and significant influence on the size of local governments on the financial performance of local governments in Indonesia; 2) There are negative and significant influences on the findings of examination of the financial performance of local governments in Indonesia; 3) There is a positive and significant influence on follow-up recommendations of examination results on the financial performance of local governments in Indonesia. The results implication is that efficiency of local government asset and follow-up of audit findings of the Audit Board Republic of Indonesia can improve the financial performance of local governments.
What Determines the Choice Between Sukuk vs Bonds?
Authors: Kusuma Wardhana Ryan , Heru Rahmat 
Published: April 2022

Funding for investments that can be obtained from various alternative sources of financing. However, the ideal funding desired by the investment manager is the most profitable funding and in line with the company's goals. Conventional bonds have long been a popular choice of management, while Islamic bonds tend not to be well recognized by management. In that, Islamic bonds have various advantages that can provide benefits to management. This study aims to investigate factors that determine public listed corporations in 3-ASEAN nations' decisions to issue corporate bonds or sukuk. For a sample of 124 sukuk and bonds issued between 2012 and 2017, we examine the influence of free cash flow as a proxy for agency cost, growth, and leverage on the decision between bond and sukuk issuance. According to the findings of binary logistic regression, firms with high free cash flow and leverage choose sukuk over conventional bonds. Firms with stronger growth, on the other hand, choose conventional bonds over sukuk. Our findings are consistent with the agency's cost-cutting strategy for free cash flow. The research has the implication that conventional bonds are preferred by fast growing companies.
Best Practices in CD30 Immunohistochemistry Testing, Interpretation, and Reporting: An Expert Panel Consensus
Authors: Gru Alejandro A. , Lim Megan S. , Dogan Ahmet , Horwitz Steven M. , Delabie Jan , Fu Kai , Peker Deniz , Reddy Vishnu V. B. , Xu Mina L. , Vij Kiran , Slack Graham W. , Miranda Roberto N. , Jagadeesh Deepa , Lisano Julie M. , Hsi Eric D. , Torlakovic Emina 
Published: April 2022

Context.—Although CD30 testing is an established tool in the diagnostic workup of lymphomas, it is also emerging as a predictive biomarker that informs treatment. The current definition of CD30 positivity by immunohistochemistry is descriptive and based on reactivity in lymphomas that are defined by their universal strong expression of CD30, rather than any established threshold. Challenges include inconsistencies with preanalytic variables, tissue processing, pathologist readout, and with the pathologist and oncologist interpretation of reported results.Objective.—To develop and propose general best practice recommendations for reporting CD30 expression by immunohistochemistry in lymphoma biopsies to harmonize practices across institutions and facilitate assessment of its significance in clinical decision-making.Design.—Following literature review and group discussion, the panel of 14 academic hematopathologists and 2 clinical/academic hematologists/oncologists divided into 3 working groups. Each working group was tasked with assessing CD30 testing by immunohistochemistry, CD30 expression readout, or CD30 expression interpretation.Results.—Panel recommendations were reviewed and discussed. An online survey was conducted to confirm the consensus recommendations.Conclusions.—CD30 immunohistochemistry is required for all patients in whom classic Hodgkin lymphoma and any lymphoma within the spectrum of peripheral T-cell lymphoma are differential diagnostic considerations. The panel reinforced and summarized that immunohistochemistry is the preferred methodology and any degree of CD30 expression should be reported. For diagnostic purposes, the interpretation of CD30 expression should follow published guidelines. To inform therapeutic decisions, report estimated percent positive expression in tumor cells (or total cells where applicable) and record descriptively if nontumor cells are positive.
High-Grade Appendiceal Mucinous Neoplasm: Clinicopathologic Findings in 35 Cases
Authors: Gonzalez Raul S. , Carr Norman J. , Liao Haihui , Pai Reetesh K. , Agostini-Vulaj Diana , Misdraji Joseph 
Published: April 2022

Context.—
High-grade appendiceal mucinous neoplasm (HAMN) is a relatively recently introduced term describing a rare epithelial neoplasm of the appendix that demonstrates pushing-type invasion but high-grade cytologic atypia. It remains understudied.

Objective.—
To describe clinicopathologic features of HAMNs.

Design.—
We identified 35 HAMNs in a multi-institutional retrospective study. Clinical and histologic features were reviewed in all cases, as well as molecular features in 8 cases.

Results.—
Patients were 57 years of age on average and most commonly presented with abdominal/pelvic pain. Histologically, 57% of the tumors showed widespread high-grade features. Architectural patterns in high-grade areas included flat, undulating, or villous growth, and occasionally micropapillary, cribriform, or multilayered growth. Thirteen cases had intact serosa, and the remaining 22 perforated the serosa, including 7 with peritoneal acellular mucin beyond appendiceal serosa and 10 with grade 2 pseudomyxoma peritonei. Molecular abnormalities included KRAS mutations in 7 cases and TP53 mutations in 4. No tumor confined to the appendix recurred. Two patients without pseudomyxoma peritonei at initial presentation developed pseudomyxoma on follow-up. Among 11 patients who presented with pseudomyxoma peritonei, 5 died of disease and 3 were alive with disease at last follow-up.

Conclusions.—
HAMNs have a similar presentation to low-grade appendiceal mucinous neoplasm, and similar stage-based prognosis. When they spread to the peritoneum, they typically produce grade 2 pseudomyxoma peritonei, which may be associated with a worse prognosis than classical grade 1 pseudomyxoma peritonei.
Understanding Sexual Consent Among Adolescents
Authors: O'Connor Carolyn , Begun Stephanie 
Published: April 2022

Background: Sexual consent remains one of the most important tools in the prevention of sexual violence, for which adolescents are an especially vulnerable group. However, it is unclear how sexual consent processes are defined and used by this population. To bridge this gap in knowledge, we present a protocol for a forthcoming scoping review that will identify and synthesize the available empirical research findings on sexual consent conceptualizations and processes among adolescents.
Methods/Design: Using the framework by Arksey and O’Malley (2005), a systematic search of six academic databases (Education Source, ERIC, Gender Studies Database, PsycINFO, Social Services Abstracts, and Sociological Abstracts) will be conducted; this range has been selected due to the multi-disciplinary nature of sexual consent research. Following two levels of screening, data from the full-text articles will be charted and subjected to qualitative thematic analysis.
Discussion: These collated results will provide a map of key concepts and establish gaps in the extant literature in order to guide future research on this topic. The findings will advance our knowledge of sexual consent as it is understood by the adolescent population; they may also inform the content and delivery of sexual education programs to ensure that they are relevant to their target audience and assist in the prevention of sexual violence.
A Study on Brand Awarness of Electric Two Wheeler in Coimbatore City
Authors: Ukesh M. , Chandrakumar M. 
Published: April 2022

The core purpose of this study is to examine the relationship of electric two wheeler consumer awareness on the subsequent purchase habits of customers around the world. For this research EVs have been defined as electric cars (EVs). Data for this research comes from Coimbatore city for the period from 2018 to 2021. Within the topic of study around EV adoption, practically all work has been done at the statistics level. The major results of this research include a considerable positive association between consumer awareness and purchase behaviors. Consistent with earlier work this analysis identified a substantial association between family income and EV sales using two separate measures, and concluded that at the regional level better policy coordination promotes a more hospitable climate for EV adoption. India is the second biggest producer and manufacturer of two-wheelers in the world. It is second to Japan and China in terms of the quantity of two wheelers manufactured and domestic sales. Indian two wheeler sector has received amazing development in the previous few years. Indian two-wheeler sector has accepted the new concept of Electric Bikes and Scooters that are highly popular form of personal transport in the developed nations like America, Japan and China. With the increases cost of fuel at International level, increasing levels of pollution and congestion in transport system notably in metropolitan areas, higher operating and maintenance cost of car, the electrically charged bikes or scooters have extremely bright future in field of personal transportation. This Paper explores about awarness of selecting the brand of electric two wheelers among consumers in Coimbatore city of Tamil Nadu and the sample gathered for the research was 120 respondents.
Van der Waals Exfoliation Processed Biopiezoelectric Submucosa Ultrathin Films
Authors: Zhang Zhuomin , Liu Shiyuan , Pan Qiqi , Hong Ying , Shan Yao , Peng Zehua , Xu Xiaote , Liu Bingren , Chai Yu , Yang Zhengbao 
Published: April 2022

AbstractPiezoelectric biomaterials have attracted significant attention due to the potential effect of piezoelectricity on biological tissues and their versatile applications. However, the high cost and complexity of assembling and domain aligning biomolecules at a large scale, and the disordered arrangement of piezoelectric domains as well as the lack of ferroelectricity in natural biological tissues remain a roadblock toward practical applications. Here, utilizing the weak van der Waals interaction in the layered structure of small intestinal submucosa (SIS), a van der Waals exfoliation (vdWE) process is reported to fabricate ultrathin films down to the thickness of the effective piezoelectric domain. Based on that, the piezoelectric property is revealed of SIS stemming from the collagen fibril, with piezoelectric coefficients up to 4.1 pm V−1 and in‐plane polarization orientation parallel to the fibril axis. Furthermore, a biosensor based on the vdWE‐processed SIS film with an in‐plane electrode is demonstrated that produces open‐circuit voltages of ≈250 mV under the cantilever vibration condition. The vdWE method shows great potential in facilely fabricating ultrathin films of soft tissues and biosensors.
Liquid‐Phase Exfoliation of Nonlayered Non‐Van‐Der‐Waals Crystals into Nanoplatelets
Authors: Kaur Harneet , Coleman Jonathan N. 
Published: April 2022

AbstractFor nearly 15 years, researchers have been using liquid‐phase exfoliation (LPE) to produce 2D nanosheets from layered crystals. This has yielded multiple 2D materials in a solution‐processable form whose utility has been demonstrated in multiple applications. It was believed that the exfoliation of such materials is enabled by the very large bonding anisotropy of layered materials where the strength of intralayer chemical bonds is very much larger than that of interlayer van der Waals bonds. However, over the last five years, a number of papers have raised questions about our understanding of exfoliation by describing the LPE of nonlayered materials. These results are extremely surprising because, as no van der Waals gap is present to provide an easily cleaved direction, the exfoliation of such compounds requires the breaking of only chemical bonds. Here the progress in this unexpected new research area is examined. The structure and properties of nanoplatelets produced by LPE of nonlayered materials are reviewed. A number of unexplained trends are found, not least the preponderance of isotropic materials that have been exfoliated to give high‐aspect‐ratio nanoplatelets. Finally, the applications potential of this new class of 2D materials are considered.
Scaling relationships of leaf vein and areole traits versus leaf size for nine Magnoliaceae species differing in venation density
Authors: Shi Peijian , Miao Qinyue , Niinemets Ülo , Liu Mengdi , Li Yirong , Yu Kexin , Niklas Karl J. 
Published: April 2022

AbstractPremiseAcross species, main leaf vein density scales inversely with leaf area (A). Yet, minor vein density manifests no clear relationship with respect to A, despite having the potential to provide important insights into the trade‐off among the investments in leaf mechanical support, hydraulics, and light interception.MethodsTo examine this phenomenon, the leaves of nine Magnoliaceae leaves were sampled, and the scaling relationships among A and midrib length (ML), total vein length (TVL), total vein area (TVA), total areole area (TAA), and mean areole area (MAA) were determined. The scaling relationships between MAA and areole density (the number of areoles per unit leaf area) and between MAA and A were also analyzed.ResultsFor five of the nine species, A was proportional to ML2. For eight of the nine species, TVL and TVA were both proportional to A. The numerical values of the scaling exponents for TAA vs. A were between 1.0 and 1.07 for eight species; i.e., as expected, TAA was isometrically proportional to A. There was no correlation between MAA and A, but MAA scaled inversely with respect to areole density for each species.ConclusionsThe correlation between midrib “density” (i.e., ML/A) and A, and the lack of correlation between total leaf vein density and A result from the A ML2 scaling relationship and the proportional relationship between TVL and A, respectively. Leaves with the same size can have widely varying MAA. Thus, leaf size itself does not directly constrain leaf hydraulic efficiency and redundancy.
Adaptation to lower latitudes and lower elevations precedes the evolution of hummingbird pollination in western North American Penstemon
Authors: Hamilton Ashley M. , Wessinger Carolyn A. 
Published: April 2022

AbstractPremiseA switch in pollinator can occur when a plant lineage enters a new habitat where the ancestral pollinator is less common, and a novel pollinator is more common. Because pollinator communities vary according to environmental tolerances and availability of resources, there may be consistent associations between pollination mode and specific regions and habitats. Such associations can be studied in lineages that have experienced multiple pollinator transitions, representing evolutionary replicates.MethodsOur study focused on a large clade of Penstemon wildflower species in western North America, which has repeatedly evolved hummingbird‐adapted flowers from ancestral bee‐adapted flowers. For each species, we estimated geographic ranges from occurrence data and inferred environmental niches from climate, topographical, and soil data. Using a phylogenetic comparative approach, we investigated whether hummingbird‐adapted species occupy distinct geographic regions or habitats relative to bee‐adapted species.ResultsHummingbird‐adapted species occur at lower latitudes and lower elevations than bee‐adapted species, resulting in a difference in their environmental niche. Bee‐adapted species sister to hummingbird‐adapted species are also found in relatively low elevations and latitudes, similar to their hummingbird‐adapted sister species, suggesting ecogeographic shifts precede pollinator divergence. Sister species pairs—regardless of whether they differ in pollinator—show relatively little geographic range overlap.ConclusionsAdaptation to a novel pollinator may often occur in geographic and ecological isolation from ancestral populations. The ability of a given lineage to adapt to novel pollinators may critically depend on its ability to colonize regions and habitats associated with novel pollinator communities.
Everyday function profiles in prodromal stages of MCI: Prospective cohort study
Authors: Verghese Joe , De Sanctis Pierfilippo , Ayers Emmeline 
Published: April 2022

AbstractIntroductionThe nature and course of limitations in everyday function in the early clinical stages of cognitive decline is not well known.MethodsWe compared complex everyday functional profiles at baseline in 59 community‐dwelling older individuals with normal cognitive performance who went on to develop incident mild cognitive impairment (MCI) (“pre‐MCI”) with 284 older individuals who remained cognitively normal over follow‐up.ResultsThe mean number of limitations on complex everyday function at baseline was 3.1 ± 3.0 in the 59 pre‐MCI cases and 2.0 ± 2.4 in the 284 normal controls (P = .003). Pre‐MCI cases had limitations in traveling, entertaining, remembering appointments, and hobbies compared to normal controls. A progressive increase in mild limitations on complex everyday function preceded the incidence of MCI (mean change: pre‐MCI 1.9 ± 3.6 vs normal controls 0.5 ± 2.7, P < .001).DiscussionProdromal stages of MCI are associated with progressive mild limitations in complex activities of daily living.
Growth of Fe‐BDC Metal‐Organic Frameworks onto Functionalized Si (111) Surfaces
Authors: Yuan Hongye , Fu Weichu , Soulmi Nadia , Serre Christian , Steunou Nathalie , Rosso Michel , Henry de Villeneuve Catherine 
Published: April 2022

AbstractThe realization of metal‐organic framework (MOF) layers onto solid surfaces is a prerequisite for their integration into devices. This work reports the direct growth of Fe3+/benzene di‐carboxylate MOFs onto functionalized silicon surfaces, compatible with a wide range of MOF synthesis conditions. The co‐nucleation and growth of different crystalline phases are evidenced, whose coverage depends on the surface chemistry and/or the solution composition. Three structural phases – the cubic MIL‐101(Fe), a hexagonal phase with a structure close to MOF‐235 and a MIL‐53(Fe) with a monoclinic symmetry ‐ are identified through characteristic crystal shapes and their structural parameters inferred from X‐Ray Diffraction. In addition to the oriented growth of 3D crystallites, the formation of two‐dimensional MIL‐101 nano‐crystallites or thin layers/islands exhibiting extended monocrystalline domains with (111) texture is also demonstrated through high‐resolution atomic force microscopy. Post‐synthesis treatments reveal a weak adhesion of the hexagonal phase, indicating a different surface anchoring.
Synthesis, Characterization, and Reaction of Digermylenes
Authors: Huo Shuai‐Cong , Li Yao , Zhang De‐Xiang , Zhou Qi , Yang Ying , Roesky Herbert W. 
Published: April 2022

AbstractA series of digermylenes R(EGeL)2 (L=CH[C(Me)N(Ar)]2, Ar=2,6‐iPr2C6H3; E=O, R=1,3‐C6H4 (1), 1,4‐C6H4 (2), Me2C(CH2)2 (3); E=NH, R=1,4‐C6H4 (4), 1,4‐C6H10 (5); E=C(O)O, R=1,3‐C6H4 (6)) were synthesized by the reactions of L′Ge (L′=HC[C(CH2)N(Ar)]C(Me)N(Ar), Ar=2,6‐iPr2C6H3) with selected diphenols, diol, diamines, and o‐/m‐phthalic acids, respectively. Treatment of digermylene 1,3‐C6H4(OGeL)2 (1) with sulfur, selenium and CuX (X=Cl, Br, I) led to the formation of 1,3‐C6H4[OGe(S)L]2 (8), 1,3‐C6H4[OGe(Se)L]2 (9), and (CuX)2[1,3‐C6H4(OGeL)2]2 (X=Cl (10), Br (11), I (12)), respectively. The obtained products were characterized by melting point, elemental analysis, FT‐IR, 1H and 13C NMR spectroscopy, and single‐crystal X‐ray diffraction.
Molecularly imprinted electrochemiluminescence sensor based on ZIF‐8 doped with CdSe quantum dots for the detection of trace estriol
Authors: Meng Yongjuan , Pu Jinling , Gan Jiamei , Li Jianping 
Published: April 2022

AbstractA composite of the metal–organic framework compound ZIF‐8 doped with CdSe quantum dots (QDs) with sensitive and stable luminescence was synthesized, and a molecularly imprinted electrochemiluminescence (ECL) sensor was constructed based on this composite. The ZIF‐8@CdSe molecularly imprinted ECL sensor combines the high sensitivity of ECL and the high selectivity of molecular imprinting to realize the sensitive and specific detection of estriol. CdSe QDs and gold nanoparticles were encapsulated within ZIF‐8 to obtain the ZIF‐8@CdSe QDs/GNP (ZIF@CdSe/GNP) composite. Subsequently, the GNPs were further loaded on the surface of this composite to obtain the GNP/ZIF@CdSe/GNP composite. l‐Cysteine was used to immobilize the GNP/ZIF@CdSe/GNP composite on the surface of a gold electrode to obtain the GNP/ZIF@CdSe/GNP‐modified gold electrode. A molecularly imprinted polymer (MIP) film was prepared on the surface of the modified electrode by electropolymerization with o‐phenylenediamine as the functional monomer and estriol as the template molecule. After elution, estriol could be specifically recognized by the cavities. The readsorption of estriol by the MIP can prevent the coreactant from reaching the electrode surface through the cavities, thereby weakening ECL. A good linear relationship existed between the ∆ECL and lg C of estriol concentrations of 1 × 10−14 to 1 × 10−9 mol·L−1. The detection limit was as low as 8.9 × 10−16 mol·L−1. The sensor was applied in the determination of estriol in serum samples with a recovery of 97.0–102%.
A child with bronchiectasis, chronic mucocutaneous candidiasis, and hypothyroidism secondary to STAT1 gain‐of‐function mutation: A case report and review of the literature
Authors: Alidrisi Dhuha , Maksood Lama , Alqahtani Wed , Minshawi Faisal , Aburziza Abdullah , Janem Waleed F. , Almatrafi Mohammed A. 
Published: April 2022

AbstractSTAT 1 GOF mutations are a rare cause of childhood primary immunodeficiency. Recurrent mucocutaneous candidiasis, chest infections, and autoimmune disease are all classic phenotype presentations. Rapid identification and diagnosis of this debilitating disease using whole exon sequencing may improve outcomes and minimize long‐term sequelae.