bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the region's energy provision
Authors: Kozlov Igor , Kovalchuk Vyacheslav , Klymchuk Oleksandr , Dorozh Olga , Sigal Alexandr , Aksyonova Inna , Elkin Yuriy 
Published: May 2022

This paper considers the task of ensuring the energy and environmental security of regions under the conditions of shortage of traditional energy resources. The method of expert assessments has been applied to justify the choice of types of acceptable energy resources that provide an increase in the relative energy supply of the territories of the regions.
A list of factors from 6 groups has been devised and compiled that includes 27 indicators characterizing the technological, environmental, and other consumer characteristics of energy resources available for use.
The maximum and minimum values of the indicator scores, the permissible intervals for their change, and the weighting coefficients that assess the importance of the indicator in the list have been determined.
The method of expert assessments is supplemented by a random number generator for the formation of an information field on the values of the characteristics of energy resources and statistical processing of data on acceptable energy resources under the conditions of the considered regions.
A quantitative comparative analysis of available energy resources and technologies based on them was carried out. It is proposed to use the acceptability index and the environmental conservation index as a criterion for the preference of a resource. Index values equal to or greater than 1 indicate resource preference. It is shown that for the base region under consideration, such resources are nuclear, solar, wind, and hydropower.
The method of expert assessments makes it possible to get an objective idea of the acceptability of using a certain energy resource to ensure energy security, taking into consideration its environmental impact in a particular region of the country.
A quantitative comparative analysis of the state of the existing structure of energy resources in the region and their availability has been carried out.
To conduct a comparative analysis of acceptability by indicators and types of resources, a graphical and analytical methodology was used. The reliability of the results obtained was assessed using a concordance coefficient.
The results could be useful for devising projects for the development and ensuring the energy security of the regions in the context of reforms
A study of benign breast disease management based on clinical, radiological and pathological assessment
Authors: Kanumuri Sravanthi , Chalamalasetty Jaya Durga , Reddy A. Suryaprakash , Punyapu Sridhar , Damam Raghavendra , Sri Narella Vasumathi Sai Lakshmi 
Published: May 2022

Benign breast disorders are usually hormone induced and therefore usually seen in the reproductive period of life with dramatic fall in incidence after menopause. As compared to breast cancers, benign breast lesions are 10 times more common.
The aim of the study was to determine the spectrum and incidence of various benign breast diseases in female patients attending our institute and to compare the results with those of other studies.
Material and methods: 80 cases of benign breast diseases which were clinically diagnosed and confirmed pathologically or radiologically were subjected for therapeutic interventions and the results were analysed.
Results: In the present study of 80 cases, the age group most affected by benign breast diseases was 21-30 years. 63 patients (78.8 %) presented with lump in the breast and 23 patients’ common symptom is pain. In most of the cases of lump had duration between 7-12 months (38.8 %), pain for 1-5 days (13.8 %), discharge for 0-5 days (11.3 %). Both breasts were involved in 6 cases (7.5 %) whereas right and left breasts are equally involved in 47 cases each (46.25 %). Most of the patients were nulliparous (46.3 %) followed by multiparous (38.8 %) and uniparous (15.0 %). Fibroadenoma constituted in 53.8 % of patients (44 cases), breast abscess constituted 21.25 % (17 cases). The most commonly affected age group was 21-30 years. 63 patients (78.8 %) presented with lump in the breast and 23 patients presented with pain. HRUSG findings correlated with that of clinical diagnosis in 70 cases. 60 cases underwent core biopsy, and in 41 cases (68.33 %) there were fibroadenoma and 7 cases (11.66 %) fibro adenosis. 59 cases (73.75 %) underwent excision, and 18 cases (22.5 %) incision and drainage.
Conclusion: The most common benign breast disease was fibroadenoma. Most common age group affected with benign breast disease was 21-30 years. 88.7 % of clinical diagnosis, 90.3 % of radiological diagnosis, 93.3 % of core needle biopsy diagnoses were correlating with the histopathology diagnosis
Self management as the key to the success of a modern health manager
Authors: Yunger Vitaly , Hbur Zoryana , Krylova Iryna 
Published: May 2022

Highlights the essence of the concept of “self-management” and provides its author's interpretation. The goals and objectives of self-management in general and separately in the field of health care are considered. It was found that in order to effectively manage the staff of a health care institution, the manager, first of all, needs to know the science and art of self-management. General and local principles of science and practice of self-management are indicated.
The aim of the article is to develop and analyze the main features of self-management as the basis of success of a modern health care manager.
Materials and research methods are general scientific research methods such as systems analysis, comparison, generalization, swat analysis, forecasting. Studying the already studied components of the selected topic, such research methods as generalization, comparison, systems analysis were used. The basis for the study were the works of domestic and foreign scientists.
Results: the article establishes that self-management helps the leader: rationally organize their work and the work of their subordinates; realize professional and life goals; avoid stressful situations; increase efficiency; enjoy the work done. An analysis of the scientific literature has led to the conclusion that strong leadership is important to ensure the success of any medical institution. A manager who pays due attention to self-development is the key to the success of a healthy atmosphere in the team. Research indicates a high level of professionalism and creativity achieved by managers only when they have a need for professional self-development, self-improvement, as well as when they show a motivational and value attitude to themselves as a subject of medical activity.
Conclusions. Summarizing the above, it should be emphasized that self-management certainly affects the development of the modern manager of health care, so the following suggestions for the implementation of this method: to overcome administrative barriers to maintaining old management methods; to avoid problems caused by the inertial nature of public consciousness; reduce the level of conflict in the team; to overcome differences in professional competence; instill immunity to the fear of sanctions of the team - ridicule, overt and covert condemnation, ignorance
Structural changes of brain vessels in cardiosurgery patients with postoperative stroke
Authors: Mankovskyi Dmytro 
Published: May 2022

Hypoxic-ischemic lesions of the brain of cardiac surgery patients as a leading factor in stroke have been studied. The importance of prolonged thrombosis, embolism, which exacerbate the general degenerative changes in the central nervous system is recognized.
The aim of the research – to study the morphological changes of the vessels of the brain of cardiac surgery patients with postoperative stroke on the background of hypoxic-ischemic complications.
Materials and methods. Pieces of cerebral vessels were subjected to microscopic examination. Histological sections were stained according to Van Gieson.
Results and their discussion. The study of the structure of the vessels of the brain of persons who were in the group intact to neurological pathology control, showed the presence of anatomical and functional changes that are fully consistent with the sex-age norms of postnatal human ontogenesis.
The drugs of the clinical observation group contained signs of pathological changes characteristic of hypoxic-ischemic disorders. It is obvious that their appearance and intensification contributed to the development of ischemic stroke. Structural and functional changes mainly concerned the vascular walls, their layers, paravasal spaces, the blood system as a liquid phase, in fact. Endothelial layer with signs of desquamation. Endothelial cells are characterized by signs of hyperchromia of the nuclei, the shift of the latter in the direction of one of the poles of the cells, the appearance of heterochromatin. Contacts between cells are weakened, defects are visible in the surface layer. Perovascular edema, which is formed in the case of increased permeability, leads to a certain isolation of individual vessels from the surrounding tissues, followed by the development of hypoxia. Defects of the wall layers lead to the activation of the migratory properties of platelets, encourage the appearance of megakaryocytes, erythrocyte thrombi, which are in close contact with the endothelial layer of blood vessels. On histological specimens, brick-red blood clots abundantly cover the damaged inner layer of vascular walls, sometimes completely filling their openings. Over time, defects in the layers of the walls are accompanied by thrombosis, inflammation, edema.
Conclusions. Hypoxic-ischemic brain lesions in cardiac surgery patients play a leading role in stroke. Priority is given to hypoxia, which contributes to ischemia, trophic disorders, atrophy, necrosis, necrobiotic changes. The latter are the organic basis of pathogenetic patterns of focal cerebral infarction (with progressive destruction of brain cells, its vessels, the development of prolonged thrombosis, embolism, increased general degenerative changes in the central nervous system)
Substituted acyl thioureas and acyl thiosemicarbazides: synthesis and biological activity (minireview)
Authors: Kholodniak Olena , Kovalenko Sergiy 
Published: May 2022

Acyl isothiocyanates and their functional derivatives (acyl thioureas and acyl thiosemicarbazides) are an important group of organic compounds that are widely used in the synthesis of heterocycles and in chemistry as catalysts, ligands, colorimetric hemosensors, etc. In recent years, there has been an increased interest towards this class of compounds as promising biologically active compounds, especially since the latest advances in medicinal chemistry for them are not sufficiently studied.
The aim. To summarize and systematize information for the last 10 years on methods of synthesis and biological activity of substituted acyl thioureas and acyl thiosemicarbazides.
Materials and methods. Web-tools for finding scientific information (Reaxys, Scopus, Google Scholar, ScienceResearch, SciFinder, Web of Science, etc.).
Results and discussion. Literature sources related to the methods of synthesis of substituted acyl thioureas and acyl thiosemicarbazides were systematized and analyzed. The main approaches for the formation of these compounds are revealed: stepwise formation from carboxylic acids, through acyl chlorides and acyl isothiocyanates followed by nucleophilic addition of amines or hydrazides of carboxylic acids ("one-pot synthesis"), nucleophilic addition of amines or hydrazides of carboxylic acids directly to acyl isothiocyanates and parallel microwave synthesis using acyl isothiocyanates and amines as reagents. The possibility of their use as ligands for the formation of complex compounds with transition metal ions was discussed. In the review biological activity of these structures, namely antimicrobial, fungicidal, antitumor, antiviral, antifungal and other activities was detailazed.
Conclusions. The basic approaches to the synthesis of substituted acylthuoureas and acyl thiosemicarbazides which include the application of carboxylic acids, their derivatives (acyl halides and isothiocyanates) and N-nucleophiles as initial compounds were discussed. It was shown that aforementioned class of the compounds reveals the versatile biological activity and are promising for further structural modification aimed to the search of novel drugs
Comparative analysis of drug consumption for the treatment of epilepsy in Ukraine, Kazakhstan and Belarus
Authors: Korzh Iuliia , Olieinikova Natalia , Beketova Marharyta , Kubarieva Inna , Korobova Yevheniia , Sevriukov Oleksandr , Afanasenko Olga 
Published: May 2022

The aim to conduct a comparative analysis of the population's consumption of antiepileptic drugs in the retail pharmaceutical markets of developing countries, including Ukraine, Kazakhstan and Belarus in the period 2016-2020.
Materials and methods. The objects of the research were the data of marketing agencies that monitor the domestic pharmaceutical market in the countries under study. In particular, the range of AED in Ukraine was determined using the market research system «Pharmstandard» of the company «Morion». Analytical-comparative, systematic, graphical, logical, mathematical-statistical research methods were used.
Results. The results of the study show that the market of antiepileptic drugs in Ukraine, Kazakhstan and Belarus mainly depends on foreign manufacturers, in particular by 60 %, 92 % and 46 % respectively in 2020, and does not meet the needs of the population in accordance with WHO recommendations. It is established that in the market of Ukraine, Kazakhstan during 2016-2019 there is a general trend of increasing retail sales of antiepileptic drugs, which are not included in the WHO Basic List of Essential Medicines, both in natural and in monetary terms. The results of the analysis of retail sales of drugs in the Belarusian market in quantitative and monetary terms indicate an increase in sales of drugs for the treatment of epilepsy, which are included in the WHO Basic List of Essential Medicines.
Conclusions. The presence in Ukraine of a difficult situation with the consumption of antiepileptic drugs in comparison with other countries of the reference group indicates the need to implement comprehensive programs to combat the spread of epilepsy and the introduction of models for the rational use of limited health resources
Perceived Barriers to Pediatric Clinical Trials Implementation: A Survey of Health Care Staff
Authors: Smith Timothy Ryan , McCulloh Russell , Bui Minh-Thuy , Sollo Natalie , Ahlers-Schmidt Carolyn , Dedeaux Julian , Davis Ann 
Published: May 2022

Introduction. Clinical trials are the gold standard for assessing the effectiveness and safety of treatments. The objective of the current study was to assess provider opinions regarding implementing pediatric clinical trials in various practice settings across Kansas.
Methods. The study was completed within the Sunflower Pediatric Clinical Trials Research Extension (SPeCTRE), an affiliate of the IDeA States Pediatric Clinical Trials Network (ISPCTN). A cross-sectional, 36-item survey was administered to a state-wide convenience sample targeting health care providers and clinic staff.
Results. A total of 119 health care providers and clinic staff completed surveys; 31% were physicians. Physicians were more likely than other clinic staff to have experience with clinical trials (correlation coefficient [CC]=0.270, p=0.004). When compared to urban respondents, rural providers were less supportive of recruitment for clinical trials in their practices (CC=-0.251, p=0.008) and more likely to feel comfortable referring patients for clinical trials involving treatments that their insurance did not cover (CC=0.302, p=0.001).
Conclusions. A range of rural and urban health care professionals support the performance of pediatric clinical trials but identify several barriers as well. These results will support future pediatric clinical trials across the country including Kansas.
Causes of Anemia in Patients Seen in a Rural Community Hematology Clinic
Authors: Featherstone Sarah , Cathcart-Rake William , Zackula Rosey , Beck Larry 
Published: May 2022

Introduction. Anemia is a common medical disorder seen in consultation by hematologists. This study was performed to determine the incidence of the etiologies causing anemia in patients referred to the hematologists at Tammy Walker Cancer Center (TWCC) in the rural Kansas community of Salina. An additional goal of the study was to compare the frequencies of different etiologies for anemia in this cohort of patients with those previously reported by four academic medical centers.
Methods. A retrospective review of the medical records of 152 patients seen at TWCC between August 2015 and May 2019 was performed. The patient’s history and physical exam, complete blood count and various additional hematologic studies ordered at the discretion of the TWCC hematologist were used to determine the etiology of each patient’s anemia.
Results. The most common causes of anemia found in the chart review were iron deficiency (48.7%), hematologic malignancy (14.5%), chronic inflammation (13.8%), renal insufficiency (11.2%), and unexplained anemia (9.9%). While the incidences of anemia due to hematologic malignancy, chronic inflammation, and renal insufficiency were similar to that reported previously by four academic medical centers, significantly more iron deficiency and less unexplained anemia were found in the patients referred to TWCC.
Conclusions. The causes of anemia in patients seen at TWCC were similar to those reported by academic medical centers; however, the incidences were different. The differences in findings may reflect dissimilarities in the demographics of referral populations, the duration and extent of the evaluation at TWCC, or referral patterns.
Investigation of Water Pollution in the River with Second-Order Explicit Finite Difference Scheme of Advection-Diffusion Equation and First-Order Explicit Finite Difference Scheme of Advection-Diffusion Equation
Authors: Laek Sazzad Andallah Nigar Sultana, 
Published: May 2022

The perseverance of this research article is to investigate water pollution in rivers with a second-order explicit finite difference scheme of advection-diffusion equation (ADE) and a first-order explicit finite difference scheme of ADE. For investigation, two numerical schemes exploit here FTCSCS and second-order Lax-Wendroff type of ADE which is our new proposed one. In earlier Lax-Wendroff, type scheme existed only for hyperbolic partial differential equation (PDE), here a new second-order Lax-Wendroff type scheme is proposed for parabolic PDE and in addition assist to investigate water pollution with an expectation of better yield compared to the existing one. We implement numerical schemes to estimate the pollutant in water at different times and different points of water bodies. We investigate the numerical behaviour of water pollution by implementing the explicit centred difference scheme (FTCSCS) for advection-diffusion and for our proposed second-order Lax-Wendroff type scheme. Our computational result verifies the qualitative behavior of the solution of ADE for various considerations of the parameters.
Success of Digital Marketing Model: Analysis for Buying Behaviour Practices of Medical Professionals
Authors: Rahul Hakhu Monika Pathak, 
Published: May 2022

Purpose – The purpose of this paper is twofold. First, is to evaluate the impact of digital marketing on the Buying behaviour Practices of medical professionals; and second, is to investigate the success factors of Digital Marketing model.
Methodology – The study employs a survey analysis for 547 Medical Professionals in Haryana, India, to determine the extent of their Purchasing Behaviour Practices via Digital Marketing through a standard structured questionnaire. The study employs the Step-wise Regression technique to identify the most relevant predictors of the Digital Marketing model.
Findings – The Predictors are Buying Behaviour practices, User friendly, Previous Buying Behaviour, Success Factors and Hindrance Factors of Digital Marketing model. Further, these predictors have been summarized each with the demographic forces as Dependent Variables i.e. Gender, Marital Status and Highest Qualifications respectively. The overall results depict that all the Models are having a significance impact on the Buying Behaviour Practices of Medical Professionals and contribute to the Success of Digital Marketing.
Originality – The success of digital marketing model for analyzing the buying behaviour practices of medical professionals with five predictors and there demographic factors as dependent variable has provided insights which add new knowledge to the extent of digital marketing techniques adopted by medical professionals and buying behaviour literature.
Modified Piezoconductivity Equation for Modeling Unsteady Filtration Processes in a Cavernous Medium
Authors: Alexey A. Bychkov, Marina V. Bereznikova Aleksander A. Bykov, 
Published: May 2022

The numeric investigation of non-stationary filtration slightly-compressible viscous fluid in porous media with high-permeable vugs was carried out. Obtained evidence that dynamic of pressure distribution in such media could not be described by solution of classical piezoconductivity equation (analogue of the heat equation). Using multipole expansion for describing pressure field perturbation was taken into account. This approach allowed to describe the change of the liquid density in porous phase near vugs during filtration and, as a result, modified piezoconductivity equation was obtained. Comparison of numeric solution of modified piezoconductivity equation with results of direct numeric simulation of filtration in heterogeneous media shows that new equation could better describe this process.
Numerical and Probabilistic Methods for Modeling of Abdominal Aortic Aneurysm Rupturing Risk
Authors: Siddig Dr. Nawal 
Published: May 2022

This study concerns to apply numerical methods and derives a comparative Abdominal Aortic Aneurysm (AAA). An accuracy comparison has been made using the index of rupturing risk versus one computed index. The study examines some factors such as age, Mean Arterial Pressure (MAP), stress-strain via the arterial wall stress (?), wall strength(S), and wall thickness (t). The qualms of AAA wall thickness are the most prevailing endogenous factors, as well as the wall stress and wall strength. A comparison between the Probabilistic Wall Rupture Index (PWRI), diameter-based index, and the output of the numerical method was done considering prediction power. Data records were taken from patients who underwent CT-Scan and ultrasound. Ten patients without rupturing cases were included in the statistical assessments. A matched diameter of a ruptured sample (n=7) and an unruptured sample (n=7) AAA was then considered. All the uncertainties that were observed in the thickness of the AAA wall and its strength were considered based originally on Laplace modified equation and PRRI analysis. The criteria for fitting a straight line to the data points were used for data graphing regarding the random nature of the collected data points. Statistical analysis (and plotting) of data was performed using MinitabTM, SPSSTM, and MatlabTM. The collagen-to- elastin ratio was taken as a measure of the AAA wall stiffness and tensile strength. The obtained results show that modified equations give a considerable coincide and minimum error compared with the original equation, and PRRI indicated a strong sensitivity more than the numerical models.