bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation-based holistic education in physiotherapy interns to increase empathy toward older adults and individuals with disabilities: a feasibility prospective study
Authors: Lin I-Hsien , Wang Chien-Yung , Lin Yen-Nung , Chen Hung-Chou , Lin Li-Fong 
Published: May 2022

Abstract
Background: With the annually increasing ratio of individuals with disabilities in an aged society, clinical clerkships for physiotherapy interns should provide more than just knowledge and skills. The cultivation of interns’ empathy and positive attitudes toward patients to meet future job requirements is essential. In this study, we explored the effect of simulation-based holistic health-care education on physiotherapy interns’ empathy, attitudes, and knowledge.Methods: A parallel-group design. Thirty physiotherapy interns in a medical institution were enrolled as participants. The experimental and control groups each had 15 participants. Both groups received standard clinical training. However, the experimental group participated in an additional simulation-based empathy enhancement program. The pretest and posttest measured the Jefferson Scale of Empathy, Kogan’s Attitudes toward Old People Scale, Attitudes Towards Elderly Scale, Knowledge about Aging scale, Knowledge of Situation of Older People, Perceptions of Working with Older People, and Care Willingness scale. Results: After the experimental group received 9 weeks intervention, the experimental group had a 6.4 points improvement on the Jefferson Scale of Empathy (p=0.001), a 7.7 points improvement on the Kogan’s Attitudes toward Old People Scale (p=0.002), a 3.5 points improvement on the Attitudes Towards Elderly Scale (p= 0.002), a 2.5 points marginal improvement on the Knowledge about Aging (p=0.055), a 4.5 points nonsignificant improvement on the Knowledge of Situation of Older People (p<0.001), a 2.1 points nonsignificant improvement on the Perceptions of Working with Older People (p=0.046), and a 0.5 points nonsignificant improvement on the CW (p=0.723),Conclusion: The simulation-based holistic health-care education intervention significantly improved physiotherapy interns’ empathy, knowledge, and attitudes.
Analysis of the disease constituent ratio and prognosis of patients undergoing ambulatory surgery in oral and maxillofacial medicine: a monocentric retrospective analysis of 427 patientsAuthors
Authors: Wang Haohong , Chi Yifan , Huang Hanxiao , Yang Mingen , Li Tingyu , Hou Jun 
Published: May 2022

Abstract
Background: Ambulatory surgery and single-visit surgery are becoming increasingly accepted and practiced worldwide due to their social and economic benefits. In China, however, their use is still insufficient and falling behind. To innovatively optimize the surgical procedure, research on the types and frequencies of surgeries is needed.Methods: The prognosis of patients also has yet to be studied. The clinical data of patients undergoing the ambulatory surgery were collected, and information on their chief complaint and basic information was specifically included. Follow-up phone calls were conducted 1 and 3 days, 1 and 2 weeks, and 1 month after treatment. Information on their recovery and well-being was collected.Results: A total of 427 patients were recruited for this study, including 224 males and 203 females. Their ages ranged from 1-68 and averaged 23.07±11. Ambulatory surgery was voluntarily selected by 43.55% of the patients. A total of 62.9% of them selected it for convenience, while 43.55% selected it for pain reduction. The three top diseases treated via ambulatory surgery were impacted teeth (56.7%). Postoperative complications occurred in 248 of the 427 patients, and the incidence rate was 58.08%. The top complication was postoperative pain (56.44%). The complications frequently occurred on Day 3 after the operation and resolved after 2 weeks. Conclusion: We believe ambulatory surgery is a safe and effective treatment for oral and maxillofacial diseases.Clinical Relevance: In current settings, ambulatory surgery can be further developed by optimizing the regulations regarding diagnosis and treatments, promoting the dissemination of medical and clinical knowledge, increasing the engagement of related personnel, and improving the professionalism and timeliness of postoperative follow-ups.
Comparison of Maxillary Tuberosity and Palatal Donor Sites for Soft Tissue Augmentation at Implant Placement.
Authors: Kotsailidi Elli Anna , Tatakis Dimitris N. , Chen Yo-wei , Caton Jack G. , Ercoli Carlo , Barmak Abdul Basir , Tsigarida Alexandra 
Published: May 2022

Abstract
Objective: To compare the outcomes of soft tissue augmentation (STA) during one-stage implant placement using grafts harvested from the hard palate (PAL) or the maxillary tuberosity (TUB).Materials and Methods: Non-smoking adults with single missing tooth, between the premolar region, and ridge dimensions adequate for implant placement were enrolled. Each received single implant and connective tissue graft harvested either from PAL (n=10) or TUB (n=10). Digital impressions were taken pretreatment (T0), and at 2 (T1) and 12 months (T2) postoperatively. Soft tissue thickness (STT) changes was the primary study outcome. Secondary outcomes included marginal bone level (MBL) changes over time, pain levels at the first two postoperative weeks (W1, W2), pink esthetic score (PES) and patient-reported outcomes (PROMs) at T2. Data analysis included repeated measures analysis of variance for intergroup comparisons.Results: STT significantly increased in both groups (p≤0.002), at all apico-coronal levels examined, with no significant intergroup differences. There was no significant intergroup difference in MBL changes (p=0.376). PAL group experienced higher donor site pain levels at W1 (p=0.023). PES and PROMs were similar between groups at T2.Conclusions: STA during one-stage implant placement results in significant STT increases. Clinical relevance: When performed simultaneously with single one-stage implants, palatal and tuberosity grafts result in similar and significant soft tissue augmentation outcomes.
Comparative investigation of catalytic application of α/β/γ-MnO2 nanoparticles synthesized by green and chemical approaches
Authors: Shehroz Hamza , Ali Sarmed , Bibi Guria , Khan Tahreem , Jamil Saba , Khan Shanza Rauf , Hashaam Muhammad , Janjua Muhammad Ramzan Saeed Ashraf 
Published: May 2022

Abstract
It is first time reported that three phases (α, β, and γ) of manganese dioxide (MnO2) are successfully stabilized in a single entity. For this purpose, Citrullus colocynthis (bitter apple) extract is used as natural surfactant in green synthesis. MnO2 nanoparticles were synthesized in the presence and absence of plant extract under same conditions. The morphology of both products are analyzed by SEM and STEM to understand the role of plant extract in controlling the morphology of particles. The crystallinity and composition are analyzed by XRD and confirmed that product is comprised of multiple phases α, β, and γ. The reduction of dyes and nitroarenes are studied by using MnO2 nanoparticles (green and chemical products) as a catalyst. Apparent rate constant, percentage reduction, time reduction and reduced concentration are determined to compare the activity of both catalysts. After comparative data analysis, the catalytic reduction of picric acid is found fastest among all the substrates. All the results are analyzed on the basis of structure, functional group and affinity towards catalyst.
Insights in forest structural diversity indicators with machine learning: What is indicated?
Authors: Ette Jana Sophie , Ritter Tim , Vospernik Sonja 
Published: May 2022

Abstract
Indicator choice is a crucial step in biodiversity assessments. Forest inventories have potential to overcome data deficits for biodiversity monitoring on large spatial scales which is fundamental to reach biodiversity policy targets. This case study focuses on indicator-indicandum relationships of structural diversity indicators in a lowland, European beech (Fagus sylvatica) dominated forest in Austria, Central Europe. We employed five indicators as surrogates for structural diversity which is an important part of forest biodiversity i.e., Clark & Evans-, Shannon, Stand Density, Diameter Differentiation index, and Crown Competition Factor. The indicators are evaluated by machine learning, to detect statistic intercorrelation in an indicator set and the relationship to twenty explanatory stand variables and five variable groups on a landscape scale. Using the R packages randomForest, VSURF, and randomForest Explainer, 1555 sample plots are considered in fifteen models.

Model outcome is decisively impacted by type and number of explanatory variables tested. Relationships to interval-scaled, common stand characteristics can be assessed most effectively. Variables of ´stand age & density´ are disproportionally indicated by our indicator set while other forest stand characteristics relevant to biodiversity are neglected. Within the indicator set, pronounced intercorrelation is detected. The Shannon index indicates overall highest, the Stand Density index lowest number of stand characteristics. Machine learning proves to be a useful tool to overcome knowledge gaps and provides additional insights in indicator-indicandum relationships.
GLUT2 expression by glial fibrillary acidic protein-positive tanycytes is required for promoting feeding-response to fasting
Authors: MJ Barahona , Langlet F , Labouèbe G , Croizier S , Picard A , Thorens Bernard , MA García-Robles 
Published: May 2022

Abstract
Feeding behavior is a complex process that depends on the ability of the brain to integrate hormonal and nutritional signals, such as glucose. One glucosensing mechanism relies on the glucose transporter 2 (GLUT2) in the hypothalamus, especially in radial glia-like cells called tanycytes. Here, we analyzed whether a GLUT2-dependent glucosensing mechanism is required for the normal regulation of feeding behavior in GFAP-positive tanycytes. Genetic inactivation of Glut2 in GFAP-expressing tanycytes was performed using Cre/Lox technology. The efficiency of GFAP-tanycyte targeting was analyzed in the anteroposterior and dorsoventral axes by evaluating GFP fluorescence. Feeding behavior, hormonal levels, neuronal activity using c-Fos, and neuropeptide expression were also analyzed in the fasting-to-refeeding transition. In basal conditions, Glut2-inactivated mice had normal food intake and meal patterns. Implementation of a preceeding fasting period led to decreased total food intake and a delay in meal initiation during refeeding. Additionally, Glut2 inactivation increased the number of c-Fos-positive cells in the ventromedial nucleus in response to fasting and a deregulation of Pomc expression in the fasting-to-refeeding transition. Thus, a GLUT2-dependent glucose-sensing mechanism in GFAP-tanycytes is required to control food consumption and promote meal initiation after a fasting period.
Maternal Performance in Relation to Food Security among Infants Aged 1-2 Years
Authors: Yeganeh Sedigheh , Motamed Niloofar , Boushehri Saeid Najafpour , Bagherzadeh Razieh , Ravanipour Maryam 
Published: May 2022

Abstract
Background: In spite of increasing awareness about food security, countries are still dealing with food insecurity. The aim of this study was to evaluate maternal performance in relation to food security during the complementary feeding in Bushehr, Iran. Methods: A cross-sectional study was carried out to select 400 mothers of children aged 1-2 years in Bushehr, using random quota sampling method. Data were collected using a localized reliable version of a 32-item food frequency questionnaire containing six subgroups (Cronbach's α: 0.81). Anthropometric indicators of height and weight were estimated in accordance with the World Health Organization (WHO) recommendations. Data analysis was performed using the Mean±SD, Median, Chi-square test, Fisher’s exact test, multinomial logistic regression, and odds ratio in SPSS, version 18.Results: As a standard serving, only 24% of the mothers fed their infant cereals, whereas 54.8%, 36.3%, 39.8%, and 20.3% of the mothers provided meat, fruits, vegetables, and dairy products, respectively. The highest correlation was found between attendance at educational classes and vegetable consumption, age at the onset of complementary feeding and the consumption of meat and fruits, and maternal educational level and dairy products. No significant relationship was found between the food groups and anthropometric indicators. Conclusions: Mothers in Bushehr performed poorly in providing a balanced diet. However, this performance can be improved by enhancing basic nutrition knowledge, holding practical education classes on food preparation, periodic evaluation of anthropometric indicators of infants, and by focusing on mothers with infants in high-risk groups (e.g., excessive weight, obesity, and malnutrition).
Effects of Sweet Potato Intercropping in Banana Orchard on Soil Microbial Population Diversity
Authors: Li Yanpei , Lin Jiaqi , Feng Dou , Deng Yingyi , Xuan Weiyan , Xiao Shixiang 
Published: May 2022

Abstract
In order to study the effect of intercropping banana and sweet potato on soil microbial diversity, high-throughput sequencing technology was used to study the population composition of soil microorganisms in banana plantation. The results showed that from May to September, the number of soil bacterial population in intercropping sweet potato was 5.54–28.67% higher than that in monoculture, and the richness and diversity of the population were significantly or extremely significantly higher than that in monoculture. The number of dominant bacterial population was less than that in monoculture, and the relative abundance of non dominant population was 10.58–58.81% higher than that in monoculture. The number, abundance and diversity of soil fungal populations in intercropping were higher than those in monoculture. The intercropping of banana and sweet potato has a significant effect on regulating the composition structure of soil microbial population and improving the abundance and diversity of microbial population. There has a great significance to improve the micro ecological environment of banana root soil and promote the stable and sustainable development of banana industry.
The performance of full-length PTH immunoassay in detecting the elevated concentration of PTH in a group of Chinese pseudohypoparathyroidism type 1 patients and its conformity with intact-PTH assay
Authors: Yang Yi , Song Ailing , Song An , Hu Yingying , Jiang Yan , Li Mei , Xia Weibo , Xing Xiaoping , Cheng Xinqi , Wang Ou 
Published: May 2022

Abstract
Purpose The efficacy of the third-generation PTH assay [PTH(1–84) assay] on evaluating PTH level among pseudohypoparathyroidism type 1 (PHP1) patients have so far been limited. Therefore, we aim to examine the conformity with intact PTH (iPTH) assay and ability in detecting elevated PTH level of PTH(1–84) assay in PHP1 patients.Methods PTH(1–84) and iPTH assay were conducted in PHP1 patients, primary hyperparathyroidism (PHPT) group and normal control group. Linear regression and conformity test was conducted within each group to examine the performance of PTH(1–84) assay against iPTH assay. ∆PTH%, 3rd/2nd ratio, iPTH/upper-limit of normal (ULN) and PTH(1–84)/ULN of each group were calculated for comparisons. Results 54 PHP1 patients, 127 PHPT patients and 65 healthy volunteers were enrolled. All the three groups presented with strong linear relationship between iPTH and PTH(1–84) (r2 = 0.9661, 0.7733 and 0.9575, respectively). Conformity examination showed the Kappa value was 0.778 and 0.395 in PHP1 and PHPT group respectively. There were no significant differences in ∆PTH% (24.4%±9.2% vs 0.76±0.09) and 3rd/2nd ratio [27.9%(-54.8%–79.7%) vs 0.72(0.20–1.55)] between PHP1 and PHPT group (p>0.05 for both). Conformity examination showed the no differences in Kappa value between PHP1A and PHP1B.Conclusion PTH(1–84) immunoassay had similar ability in examining elevated PTH level among PHP1 patients when comparing to the mostly applied iPTH assay.
Brain Tumor Segmentation Using Modified U-Net
Authors: sami eman , Ebied Hala M. , Amin Safaa , Hassaan Mosab 
Published: May 2022

Abstract
Purpose: Planning and evaluating the extent of the spread of brain tumors for the treatment is the main challenge. Magnetic resonance imaging (MRI) has been shown as a great diagnostic tool for brain tumors without harmful radiation. We have found in using the traditional U-net, that there are some errors in identifying the tumor, so we wanted to develop this method so that it overcomes some errors in determining the tumor in the traditional method. Methods: We demonstrate a way to segment the brain tumor using modify U-net networks. Then compared with traditional U-net, modified U-net, k-means, and thresholding segmentation. The experiments were carried out using three multimodal brain tumor image segmentation datasets (FIGSHARE database), which contain 3929 abnormal (with a tumor) and normal brain MRI images, 100 images obtained from “The Cancer Imaging Archive (TCIA)” and BraTS 2019 challenge which include 4600 cases (normal and abnormal) of HGG (high-grade glioma) and LGG(low-grade glioma).Results: Through this study, the modified U-net achieved higher accuracy than other methods.Conclusion: Determining the tumor inside the human brain is an important matter to preserve human life. We used old and modern techniques and modified the basic form of the traditional U-net. The above-mentioned techniques were compared and the experiment was done on many data from different sources. It was found that the modified U-net is the best accurate.
Virus classification for viral genomic fragments using PhaGCN2
Authors: Jiang Jing-Zhe , Yuan Wen-Guang , Shang Jiayu , Shi Ying-Hui , Yang Li-Ling , Liu Min , Zhu Peng , Jin Tao , Sun Yanni , Yuan Li-Hong 
Published: May 2022

Abstract
Background: Viruses are the most ubiquitous and diverse entities in the biome. Due to the rapid growth of newly identified viruses, there is an urgent need for accurate and comprehensive virus classification, particularly for novel viruses.Results: Here, we present PhaGCN2, which can rapidly classify the taxonomy of viral sequences at family level and supports the visualization of the associations of all families. We evaluate the performance of PhaGCN2 and compare it with the state-of-the-art virus classification tools, such as vConTACT2, CAT, and VPF-Class, using the widely accepted metrics. The results show that PhaGCN2 largely improves the precision and recall of virus classification, increases the number of classifiable virus sequences in the Global Ocean Virome dataset (v2.0) by 4 times, and classifies more than 90% of the Gut Phage Database. Conclusions: Here, we present PhaGCN2, which can rapidly classify the taxonomy of viral sequences at family level and supports the conduction of high-throughput and automatic expansion of the database of the International Committee on Taxonomy of Viruses.
Predictors of five-repetition sit-to-stand test performance in patients with lumbar degenerative disease
Authors: Klukowska Anita M. , Staartjes Victor E. , Vandertop W. Peter , Schröder Marc L. 
Published: May 2022

Abstract
Objective: The five-repetition sit-to-stand test (5R-STS) has recently been validated as an objective measure of functional impairment in patients with lumbar degenerative disease (LDD). Knowledge of factors influencing 5R-STS performance is useful to correct for confounders, create personalized adjusted test times, and to potentially identify prognostic subgroups. We evaluate factors predicting the 5R-STS performance in patients with LDD. Methods: Patients with LDD requiring surgery were included. Each participant performed the 5R-STS and completed a questionnaire that included their age, gender, weight, height, body mass index (BMI), smoking status, education level, employment type, ability to work, analgesic drug usage, history of previous spinal surgery and EQ5D Depression & Anxiety domain. Surgical indication and index level of the spinal pathology were also recorded. Predictors of 5R-STS were identified through multivariable linear regression. Results: The cohort consisted of 240 patients, 47.9% being female (mean age: 47.7±13.6 years). In the final multivariable model incorporating confounders, height (regression coefficient [RC]: 0.08, 95% confidence interval [CI]: 0.003/0.16, p=0.042) and being an active smoker (RC: 2.44, 95%CI: 0.56/4.32, p=0.012) were significant predictors of worse 5R-STS performance. Full ability to work (RC: -2.39, 95%CI: -4.39/-0.39, p=0.020) was associated with a better 5R-STS performance. Age, height, surgical indication, index level of pathology, history of previous spine surgery, history of pain, analgesic drug use, employment type and severity of anxiety & depression symptoms demonstrated confounding effect on the 5R-STS time.Conclusions: Greater height, being an active smoker, and inability to work are significant predictors of worse 5R-STS performance in patients with LDD. (ClinicalTrials.gov Identifier: NCT03303300 and NCT03321357)
Don’t blame psychosis, blame the lack of services. A message for Early Intervention
Authors: Dimitrakopoulos Stefanos , Stefanatou Pentagiotissa , Vlachos Ilias , Selakovic Mirjana , Xenaki Lida-Alkisti , Ralli Irene , Soldatos Rigas-Filippos , Nianiakas Nikolaos , Kosteletos Ioannis , Foteli Stefania , Mantonakis Leonidas , Kollias Costas T. , Stefanis Nikos C. 
Published: May 2022

Abstract
Background. Early Intervention Services (EIS) aim to reduce relapse rates and achieve better treatment and functional outcomes for first episode psychosis (FEP) patients. Reform of mental health services is underway in Greece and initial steps have been taken to shift standard care towards EIS.Methods. We examined follow-up and relapse rates one year after initial treatment contact in the first longitudinal FEP study conducted in Greece. 225 patients were enrolled between 2015-2020. Sociodemographic, clinical and functional characteristics were assessed in association with follow-up and relapse rates.Results. Within a treatment as usual follow-up setting, one year attrition rates were high. Only 87 patients (38,7%) retained contact with services after one year and within this time frame, 19 of them (21,8%) experienced a severe relapse requiring rehospitalization.Conclusion. Both follow-up and one-year rehospitalization rates in our FEP sample, highlight the need for the implementation of early intervention services, that will aim at follow-up engagement maximization and relapse prevention. These indexes also provide a benchmark against which future early intervention services for psychosis in Greece will have to demonstrate superior efficacy.