bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical implications of first-trimester ultrasound dating in singleton pregnancies obtained through in vitro fertilization
Authors: Rapisarda Agnese Maria Chiara , Somigliana Edgardo , Dallagiovanna Chiara , Reschini Marco , Pezone Maria Grazia , Accurti Veronica , Ferrara Giuditta , Persico Nicola , Boito Simona 
Published: August 2022

Background
In pregnancies obtained by in-vitro fertilization (IVF) the exact day of conception is known. For that reason, IVF pregnancies are currently dated according to the day of oocytes retrieval and consequent embryo transfer. The aim of the present study is to determine whether the knowledge of the exact day of conception in IVF pregnancies is a sufficient argument against dating these pregnancies by first trimester ultrasound measurement of the crown-rump length (CRL), as it is recommended in natural conceptions.

Methods
A retrospective study was performed, including all women with singleton pregnancies conceived by IVF who underwent the first-trimester ultrasound scan for the screening of aneuploidies between January 2014 and June 2019. For each pregnancy GA was determined using two alternative methods: one based on the date of embryo transfer (GAIVF), and one based on ultrasound measurement of CRL (GAUS). GA were compared to search for any discrepancy. The impact of pregnancy dating on obstetric outcome was evaluated.

Results
Overall, 249 women were included. Comparing GAUS and GAIVF, a median difference of 1 [0 – 2] days emerged (p<0.001), with GAUS being in advance compared to GAIVF. This discrepancy persisted when subgroups were analyzed comparing different IVF procedures (conventional IVF versus ICSI, cleavage versus blastocyst transfer, frozen versus fresh transfer). No impact of the dating method on obstetric outcomes was observed, being no differences in the rate of preterm birth or abnormal fetal growth.

Conclusions
In IVF pregnancies GAUS and GAIVF are not overlapping, since GAUS is mildly greater than GAIVF. This could be due to an anticipated ovulation and fertilization in IVF pregnancy, rather than an accelerated embryo development. For that reason, it would be appropriate to date IVF pregnancies according to GAUS, despite a known date of conception, to re-align IVF pregnancies to natural ones.
Association between proteinuria trajectories and outcomes in critically ill patients with sepsis or shock
Authors: Monge Raphael , Oris Charlotte , Jabaudon Matthieu , Braïlova Marina , Futier Emmanuel , Sapin Vincent , Pereira Bruno , Lautrette Alexandre 
Published: August 2022

Background
Proteinuria results from kidney damage and can be a predictor of illness severity and mortality in the intensive care unit (ICU). However, the optimal timing of proteinuria measurements and the reference values remain undetermined. Our objective was to identify the patterns of proteinuria change associated with mortality in ICU patients with sepsis or shock.

Methods
This monocentric retrospective cohort study performed from April 2010 to April 2018 involved all ICU patients with sepsis or shock and at least two measurements of proteinuria from a 24h-urine collection during the first 10 days of ICU stay, the first of which was made within 48h after ICU admission. We identified proteinuria trajectories by a semi-parametric mixture model and analysed the association between the trajectories and the mortality at day 28 by Cox proportional-hazards model.

Results
A total of 3,344 measurements of proteinuria from 659 patients were analysed. Four proteinuria trajectories were identified. Trajectories 1, 2, 3 and 4 comprised 127, 421, 60 and 51 patients, and were characterized by a first proteinuria of 1.14 [0.66–1.55], 0.52 [0.26–0.91], 2.92 [2.38–3.84] and 2.58 [1.75–3.32] g/24h (p<0.001) and a mortality of 24.4%, 38%, 20% and 43% (p = 0.002), respectively. Trajectories 3 and 4 had a high first proteinuria (>2g/24h). Only, the proteinuria of trajectory 4 increased within 3 days following the first measurement and was associated with increased mortality at day 28 (hazard ratio: 2.36 95%CI [1.07–5.19], p = 0.03), regardless of acute renal failure. The factors associated with trajectory 4 were cancer (relative risk: 8.91 95%CI [2.09–38.02], p = 0.003) and use of inotropic drugs (relative risk: 0.17 95%CI [0.04–0.69], p = 0.01).

Conclusion
This exploratory study of ICU patients with sepsis or shock identified four proteinuria trajectories with distinct patterns of proteinuria change over time and mortality rates. These results provide novel insights into renal pathophysiology and may be helpful to investigate subphenotypes of kidney injury among ICU patients in future studies.
Tuberculosis at a university hospital, Thailand: A surprising incidence of TB among a new generation of highly exposed health care workers who may be asymptomatic
Authors: Mingchay Pichanon , Paitoonpong Leilani , Kawkitinarong Kamon , Ohata Pirapon June , Suwanpimolkul Gompol 
Published: August 2022

Objectives
There are a few reports of TB disease among healthcare workers (HCWs) in Thailand. The authors assessed the demographic data and incidence of overall TB disease including specific profession among HCWs in order to reduce the incidence rate.

Methods
This was a descriptive, cross-sectional study of 195 HCWs at King Chulalongkorn Memorial Hospital (KCMH), Bangkok, Thailand, who had TB disease from 2003–2020.

Results
The average incidence of TB disease in HCWs at KCMH was 164 per 100,000 HCWs with 95% confidential interval [CI], 107 to 220; (94.4% had pulmonary TB). Most of the HCWs were from a young age group (43.08% were 20–29 years old) and the duration of work was short (58.82% had worked at KCMH for less than 5 years). Radiological technicians had the highest incidence of TB, followed by supportive teams, scientists, and physicians (429, 241, 205, and 193 per 100,000 HCWs according to their profession, respectively). Seventy five percent of TB disease was found in physicians who worked at KCMH within 2 years. TB incidence was highest among residents (688 per 100,000 residents) in a subgroup of physicians.

Conclusions
The incidence of TB disease in HCWs was close to the general population of Thailand (153 per 100,000 population with 95% CI, 116 to 195). A higher incidence was observed in the profession that had contact with TB patients and their specimens. A high proportion of asymptomatic HCWs also had TB disease and TB incidence was found in a new generation of HCWs who have worked for less than 5 years. More rigorous epidemiology investigations are needed to establish a definitive relation to subsequently developing TB after working in a hospital. The authors suggest active surveillance in all new incoming HCWs and TB preventive therapy should also be provided to recent converters.
Plovdiv – In foreign language educational environment
Authors: Petrova Elka , Yanev Boryan , Boykova Fani 
Published: August 2022

The poster summarizes the results of the series of training seminars held in a foreign language environment. As a central part of the activities is the realized associative experiment, which allows observing the process of formation of a secondary linguistic personality; composing features of the interweaving of the elements in the structure of the linguistic picture of the world; tracing the peculiar layering of cognitive data and researching the specifics of the national culture in the mind of students during the reception of a foreign language. The associative experiment is, by its nature, a current educational method, especially in the context of the relationship between language and culture and the emphasis on multicultural education.
An associative experiment was included in the training, based on the idea of the fundamental unity of the psychological basis of association and the semantic components of meaning, rereading in its way the method of associative. It is important to explain that our understanding of an association is a mental connection that arises between representations, is based on individual subjective experience, but is directly related to the social cognition of the individual. Each of the existing types of the associative experiment is designed to solve a certain set of pre-set problems and, accordingly, has its advantages and disadvantages. For example, in our opinion, the directed associative experiment helps to obtain specific reactions having certain characteristics, but in this way, the process of association is relatively limited and to some extent controlled by the researcher, which can lead to subjective results.In our research, we have used a free-associative experiment of the principle – S (stimulus) – R (reactions). Based on the quantity laid down in Kent and Rozanov's model, we selected 100 stimulus words (50 adjectives, and 50 nouns related to the city of Plovdiv). The selection of lexemes took into account the fact that the respondents were foreigners and included only words that are part of the initial level of language proficiency. The results from the experiment allow us, from the point of view of semantics, to generalize the received reactions into some classification groups. A summary of the data is presented in this poster. In conclusion, the experiment allowed us to outline both the achieved effect of the interactive learning method and to see the specific features of the interweaving of cognitive structures in the minds of foreign learners.
The authors express sincere gratitude to the Scientific Research Fund at the Ministry of Education and Science and the "Scientific and Project Activity" Division at Plovdiv University "PaisiiHilendarski" for the assistance provided.
Periodontal Treatment and Usual Care for Nonalcoholic Fatty Liver Disease: A Multicenter, Randomized Controlled Trial
Authors: Kamata Yohei , Kessoku Takaomi , Shimizu Tomoko , Sato Satsuki , Kobayashi Takashi , Kurihashi Takeo , Morozumi Toshiya , Iwasaki Tomoyuki , Takashiba Shogo , Hatanaka Kazu , Hamada Nobushiro , Kodama Toshiro , Higurashi Takuma , Taguri Masataka , Yoneda Masato , Usuda Haruki , Wada Koichiro , Nakajima Atsushi , Minabe Masato 
Published: August 2022

INTRODUCTION:
Periodontal disease is associated with nonalcoholic fatty liver disease (NAFLD). We evaluated periodontal treatment efficacy in patients with NAFLD and periodontal disease.

METHODS:
This multicenter, 2-arm, randomized study recruited adult patients with NAFLD and periodontitis, alanine aminotransferase levels ≥40 U/L, and equivalent steatosis grade ≥1. Forty eligible patients (18 men and 22 women) were randomly assigned to 2 groups (scaling and root planning [SRP; n = 20] and tooth brushing [n = 20] groups) stratified by age and sex. The primary and secondary endpoints were changes in alanine aminotransferase levels and serum Porphyromonas gingivalis IgG antibody titers from baseline to 12 weeks, respectively. Efficacy analysis was performed using an intention-to-treat approach (t test). This trial was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN000022079).

RESULTS:
We observed a significantly higher decrease in absolute alanine aminotransferase levels and P. gingivalis IgG antibody titers in the SRP group than in the tooth brushing group (−12 vs 1 U/L; mean difference [δ], −12; 95% confidence interval [CI], −20 to −5; P = 0.002). The decrease in P. gingivalis IgG antibody titer was significantly higher in the SRP group than in the tooth brushing group (FDC381, −1.6 [2.5]; δ, −1.6; 95% CI, −2.7 to −0.4; P = 0.0092; SU63, −1.7 [2.0]; δ, −1.7; 95% CI, −2.7 to −0.7). No life-threatening events or treatment-related deaths occurred.

DISCUSSION:
Periodontal treatment induced significant short-term and mid-term reductions in liver enzyme levels and antibody titers. Further research is warranted to clearly define SRP efficacy and tolerability in patients with NAFLD and periodontitis.
Enrichment of Patients With Ehlers Danlos Syndrome in Idiopathic Gastroparesis—A Gene Set Enrichment Analysis
Authors: Smieszek Sandra P. , Carlin Jesse L. , Fisher Michaela A. , Madonick Darby S. , Kupersmith Caleigh Q. , Moszczynski Paula D. , Xiao Changfu , Polymeropoulos Christos M. , Birznieks Gunther , Polymeropoulos Mihael H. 
Published: August 2022

INTRODUCTION:
Ehlers Danlos syndrome (EDS) is a heritable disorder of the connective tissue usually inherited as an autosomal dominant trait. We observe an enrichment of EDS cases in a gastroparesis clinical study.

METHODS:
We explored the frequency of EDS cases in 2 consecutive gastroparesis clinical studies. To explore the genetic surrogates of EDS, we have performed whole-genome sequencing analysis and we focused the analyses on the frequencies of consequential variants in core EDS genes.

RESULTS:
We report a significant enrichment of EDS cases in a set of patients with gastroparesis (14/686 vs 1/5,000 OR 104 (confidence interval 13.7–793.3) P value <0.0001). We report a significant enrichment of variants in EDS genes in patients with idiopathic gastroparesis.

DISCUSSION:
The enrichment may be suggestive of converging pathways at the heart of etiology or predisposing patients to EDS with gastroparesis.
OPTIMIZING DISTRIBUTION ROUTE OF PACKED DRINKING WATER WITH THE CLARKE AND WRIGHT SAVINGS AND NEAREST NEIGHBOR METHODS (Case Study of PT. GSI)
Authors: Kurniawati Dwi Agustina , Rian Puji Kusuma  , Dwi Kristanto  , Noordin Mohd. Yusof  , Kuan Yew Wong  
Published: August 2022

In the business, distribution has a very important role. The distribution process must be able to deliver products on time while it also reduces the transportation costs which can consume around 50% of the company's total logistics costs. If distribution costs can be reduced, it can indirectly increase the company’s profit. PT. GSI, located in Yogyakarta, is a distributor of packed drinking water company with brand “PLG”. In determining the distribution route, PT. GSI does not use any scientific method and only uses the driver’s intuition. The purpose of this study is to optimize the distribution route of the “PLG” packed drinking water delivery to obtain the minimum mileage by using the Clarke and Wright Savings and Nearest Neighbor methods. The Clarke and Wright Savings method and the Nearest Neighbor method are used because the customer locations are far from each other and there are also customers whose delivery locations are centered on one delivery area, so that the calculation of distance savings is needed. Then the evaluation is done to determine which method is better. The comparison of the solution for data on 1st ,2nd ,3rd ,4th, and 6th March 2021 showed that the Nearest Neighbor method proposed best solution while data on 5th March 2021 showed that Clarke and Wright Savings giving the best solution. The results show that the Nearest Neighbor method provides better result in determining the distribution routes of PT. GSI.
Maximal asymmetry of bivariate copulas and consequences to measures of dependence
Authors: Griessenberger Florian , Trutschnig Wolfgang 
Published: August 2022

Abstract
In this article, we focus on copulas underlying maximal non-exchangeable pairs

(

X
,
Y

)

\left(X,Y)

of continuous random variables

X
,
Y

X,Y

either in the sense of the uniform metric

d

∞

{d}_{\infty }

or the conditioning-based metrics

D

p

{D}_{p}

, and analyze their possible extent of dependence quantified by the recently introduced dependence measures

ζ

1

{\zeta }_{1}

and

ξ

\xi

. Considering maximal

d

∞

{d}_{\infty }

-asymmetry we obtain

ζ

1

∈

5

6

,
1

{\zeta }_{1}\in \left[\frac{5}{6},1\right]

and

ξ
∈

2

3

,
1

\xi \in \left[\frac{2}{3},1\right]

, and in the case of maximal

D

1

{D}_{1}

-asymmetry we obtain

ζ

1

∈

3

4

,
1

{\zeta }_{1}\in \left[\frac{3}{4},1\right]

and

ξ
∈

1

2

,
1

\xi \in \left(\frac{1}{2},1\right]

, implying that maximal asymmetry implies a very high degree of dependence in both cases. Furthermore, we study various topological properties of the family of copulas with maximal

D

1

{D}_{1}

-asymmetry and derive some surprising properties for maximal

D

p

{D}_{p}

-asymmetric copulas.
Therapeutic drug monitoring of teriflunomide: do plasma concentrations predict response to leflunomide in patients with rheumatoid arthritis?
Authors: Rawdha Tekaya , Aicha Ben Tekaya , Lobna Ben Ammar , Issam Salouaje , Mouna Ben Sassi , Olfa Saidane , Selma Bouden , Takoua Ben Brahim , Kawther Ben Abdelghani , Leila Metoui , Hana Sahli , Ines Mahmoud , Leila Abdelmoula 
Published: August 2022

Abstract

Objectives
Leflunomide is a commonly used treatment for rheumatoid arthritis. It acts by inhibiting dihydroorotate dehydrogenase through its active metabolite teriflunomide. The objective of the study was to investigate the relation between plasma-concentration of teriflunomide and disease-activity in rheumatoid arthritis.

Methods
Data were collected from patients with rheumatoid arthritis on a stable leflunomide dose for at least 2 months. Socio-demographic data, disease characteristics and DAS28 score were recorded. Blood samples were taken for determination of teriflunomide concentration.

Results
A total of 32 serum concentration-time measurements were collected. The concentration of teriflunomide was positively correlated with disease duration of RA (r2=0.2264) and the number of swollen joints (r2=0.2413). There was a trend towards a positive correlation between Health Assessment Questionnaire (HAQ) and plasma teriflunomide concentration (r2=0.1699). Weight was negatively correlated with the residual plasma concentration of teriflunomide (r2=0.2483). However, there was no significant correlation between residual-plasma-concentration of teriflunomide and the following parameters: age, sex, number of tender painful joints, patient-global-assessment, C-reactive protein (CRP) and duration of prescription of leflunomide. We did not find association between disease-activity and residual-plasma-concentration of teriflunomide (r2=0.0021) and haven’t been able to define the threshold value of residual-plasma-concentration of leflunomide predictive of a good-response.

Conclusions
We did not find a concentration-effect-relationship. However, therapeutic drug monitoring of teriflunomide may be useful to ensure adherence and evaluate toxic-levels in case of adverse-events.
Diabetic ketoacidosis in children with new-onset type 1 diabetes mellitus: demographics, risk factors and outcome: an 11 year review in Hong Kong
Authors: Poon Sarah Wing-yiu , Tung Joanna Yuet-ling , Wong Wilfred Hing-sang , Cheung Pik-to , Fu Antony Chun-cheung , Pang Gloria Shir-wey , To Sharon Wing-yan , Wong Lap-ming , Wong Wai-yu , Chan Suk-yan , Yau Ho-chung , See Wing-shan , But Betty Wai-man , Wong Shirley Man-yee , Lo Priscilla Wai-chee , Ng Kwok-leung , Chan Kwong-tat , Lam Hi-yuet , Wong Sammy Wai-chun , Lam Yuen-yu , Yuen Hoi-wing , Chung Jacky Ying-ki , Lee Ching-yee , Tay Ming-kut , Kwan Elaine Yin-wah 
Published: August 2022

Abstract

Objectives
Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes (T1D). The aim of this study is to analyze the incidence, clinical characteristics, management and outcome of children presenting with DKA in new-onset T1D from 2008 to 2018 in Hong Kong.

Methods
Data was extracted from the Hong Kong Childhood Diabetes Registry. All subjects less than 18 years with newly diagnosed T1D from 1 January 2008 to 31 December 2018 managed in the public hospitals were included. Information on demographics, laboratory parameters, DKA-related complications and management were analyzed.

Results
In the study period, there were 556 children with newly diagnosed T1D in our registry and 43.3% presented with DKA. The crude incidence rate of new-onset T1D with DKA was 1.79 per 100,000 persons/year (CI: 1.56–2.04). Subjects presenting with DKA were younger (9.5 ± 4.5 vs. 10.5 ± 4.4, p=0.01) and had shorter duration of symptoms (4.2 ± 5.9 days vs. 10.6 ± 17.1 days, p<0.01). Regarding management, up to 12.4% were given insulin boluses and 82.6% were started on insulin infusion 1 h after fluid resuscitation. The rate of cerebral edema was 0.8% and there was no mortality.

Conclusions
Younger age and shorter duration of symptoms were associated with DKA in new-onset T1D. Despite availability of international guidelines, there was inconsistency in acute DKA management. These call for a need to raise public awareness on childhood diabetes as well as standardization of practice in management of pediatric DKA in Hong Kong.
The crystal structure of 1,5-bis(4-chlorophenyl)-3-(3-methylphenyl)pentane- 1,5-dione, C48H40Cl4O4
Authors: Li Zhen , Liu Wanxing , Wang Baolei , Yang Yanbing , Liu Dong , Dai Yifan 
Published: August 2022

Abstract
C48H40Cl4O4, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 7.1407(5) Å, b = 12.5905(8) Å, c = 24.6662(17) Å, α = 103.442(6)°, β = 93.551(5)°, γ = 101.219(5)°, V = 2102.3(2) Å3, Z = 2, R

gt
(F) = 0.0595, wR

ref
(F
2) = 0.1641, T = 293 K.
The crystal structure of imidazolium nitrate, C3H5O3N3
Authors: Xiao Li , Hongxia Pan , Qiang Liu , Lei Gong , Lizhen Chen , Jianlong Wang 
Published: August 2022

Abstract
C3H5O3N3, tetragonal, P43212 (no. 96), a = 7.2479(2) Å, c = 21.6138(8) Å, V = 1135.42(8) Å3, Z = 8, Rgt
(F) = 0.0344, wRref
(F
2) = 0.0903, T = 100 K.
Using IPA tools to characterize molecular pathways underlying the involvement of IRF7 in antiviral response to HIV
Authors: Kota Nikhil K. , Vigorito Michael , Krishnan Velu , Chang Sulie L. 
Published: August 2022

Abstract

Objectives
Interferon Regulatory Factors (IRFs) regulate transcription of type-I interferons (IFNs) and IFN-stimulated genes. We previously reported that IFN-regulatory factor 7 (IRF7) is significantly upregulated in the brain of HIV-1 transgenic (HIV-1Tg) rats compared to F344 control rats in a region dependent manner [Li MD, Cao J, Wang S, Wang J, Sarkar S, Vigorito M, et al. Transcriptome sequencing of gene expression in the brain of the HIV-1 transgenic rat. PLoS One 2013]. The RNA deep-sequencing data were deposited in the NCBI SRA database with Gene Expression Omnibus (GEO) number GSE47474. Our current study utilized QIAGEN CLC Genomics Workbench and Ingenuity Pathway Analysis (IPA) to identify molecular pathways underlying the involvement of IRF7 in the HIV antiviral response.

Methods
The differential RNA expression data between HIV-1Tg and F344 rats as well as HAND+ and HIV+ cognitively normal patients was collected from GSE47474 and GSE152416, respectively. The “Core Expression Data Analysis” function identified the significant canonical pathways in the datasets with or without IRF7 and its 455 associated molecules.

Results
It was found that IRF7 and its 455 associated molecules altered the expression of pathways involving neurotransmission, neuronal survival, and immune function.

Conclusions
This in-silico study reveals that IRF7 is involved in the promotion of macrophage activity, neuronal differentiation, the modulation of the Th-1/Th-2 ratio, and the suppression of HIV-1 translation. Furthermore, we demonstrate that bioinformatics tools such as IPA can be employed to simulate the complete knockout of a target molecule such as IRF7 to study its involvement in biological pathways.