bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daily interpersonal conflicts and daily exposure to bullying behaviors at work: The moderating roles of trait anger and trait anxiety
Authors: Zahlquist Lena , Hetland Jørn , Einarsen Ståle V. , Bakker Arnold B. , Hoprekstad Øystein L. , Espevik Roar , Olsen Olav K. 
Published: May 2022

AbstractBuilding on the three‐way model of workplace bullying and its underlying theories, this study investigates the role of trait anger and trait anxiety in the link between daily interpersonal conflicts and daily exposure to bullying behaviors. Using a quantitative diary study design, we approached 57 military naval cadets participating in a tall‐ship voyage across the Atlantic, from Europe to North America, in 2017. They responded to a questionnaire on a daily basis over a period of 30 days—yielding 1428 measurement points. Prior to the voyage, participants also responded to a general questionnaire including measures of trait anger and trait anxiety. As hypothesized, multilevel analyses showed positive main effects of daily interpersonal conflicts on interpersonal conflicts the next day and exposure to bullying behaviors the same day. However, daily involvement in interpersonal conflicts did not predict exposure to bullying behaviors the next day. Moreover, and in support of the hypothesized moderating effects, trait anger (but not trait anxiety) interacted positively with daily interpersonal conflicts in the prediction of interpersonal conflicts the next day as well as exposure to bullying behaviors the same day. The study suggests that interpersonal conflicts persist and have an immediate effect on exposure to bullying behaviors and that this is particularly the case for individuals high (vs. low) on trait anger. We discuss how these findings contribute to the three‐way model of workplace bullying, as well as possible practical implications.
lncRNA XLOC013218 promotes cell proliferation and TMZ resistance by targeting the PIK3R2‐mediated PI3K/AKT pathway in glioma
Authors: Zhou Jian , Xu Ningbo , Liu Boyang , Wang Chenyang , He Zhenyan , Lenahan Cameron , Tang Wenhui , Zeng Huijun , Guo Hongbo 
Published: May 2022

AbstractThe discovery of long noncoding RNAs (lncRNAs) has improved the understanding of development and progression in various cancer subtypes. However, the role of lncRNAs in temozolomide (TMZ) resistance in glioblastoma multiforme (GBM) remains largely undefined. In this present study, the differential expression of lncRNAs was identified between U87 and U87 TMZ‐resistant (TR) cells. lncRNA XLOC013218 (XLOC) was drastically upregulated in TR cells and was associated with poor prognosis in glioma. Overexpression of XLOC markedly increased TMZ resistance, promoted proliferation, and inhibited apoptosis in vitro and in vivo. In addition, RNA‐seq analysis and gain‐of‐function or loss‐of‐function studies revealed that PIK3R2 was the potential target of XLOC. Mechanistically, XLOC recruited specificity protein 1 (Sp1) transcription factor and promoted the binding of Sp1 to the promoters of PIK3R2, which elevated the expression of PIK3R2 in both mRNA and protein levels. Finally, PIK3R2‐mediated activation of the PI3K/AKT signaling pathway promoted TMZ resistance and cell proliferation, but inhibited cell apoptosis. In conclusion, these data highlight the vital role of the XLOC/Sp1/PIK3R2/PI3K/AKT axis in GBM TMZ resistance.
Association between serum β‐oestradiol and health‐related quality of life in postmenopausal women with degenerative lumbar scoliosis
Authors: Tian Lijun , Guo Yusong , Guo Zheming 
Published: May 2022

AbstractObjectivesDegenerative lumbar scoliosis (DLS) is an age‐related spinal disease. It is an important cause of low back pain, lower limb pain and intermittent claudication, which seriously affects the quality of life of middle‐aged and elderly people. Design: This article aims to study the changes in serum oestrogen levels in postmenopausal women with DLS and its relationship.PatientsOne hundred and sixty‐eight postmenopausal women diagnosed with DLS (DLS group) and 140 healthy postmenopausal women (control group) were recruited. Measurements: Lumbar spinal bone mineral density (LSBMD) was measured by dual‐energy X‐ray absorptiometry and a chemiluminescence immunoassay analyser was used to detect serum β‐oestradiol (E2) levels. The severity of lower back pain was assessed by the visual analogue scale score and dysfunction was evaluated by Oswestry Disability Index (ODI). The quality of life was evaluated by Medical Outcomes Study 36‑item Short Form Health Survey (SF‑36). Diagnostic efficiency was evaluated by the receiver‐operating characteristics curve (ROC).ResultsLSBMD and the level of E2 in the serum in DLS patients were significantly reduced when compared with the control group. The levels of E2 in the serum of postmenopausal women are reliable for predicting DLS revealed by ROC (p < .001). Serum E2 levels were negatively correlated with Cobb angle, VAS and ODI and were positively correlated with LSBMD and SF‐36 scores.ConclusionsIn postmenopausal women, serum E2 levels in DLS patients are significantly reduced and low levels of E2 are associated with lower bone density and poorer quality of life.
Implications of considering peri‐implant bone loss a disease, a narrative review
Authors: Albrektsson Tomas , Tengvall Pentti , Amengual‐Peñafiel Luis , Coli Pierluigi , Kotsakis Georgios , Cochran David L. 
Published: May 2022

AbstractBackgroundPeri‐implantitis has been suggested to cause significant increasing proportions of implant failure with increasing time.PurposeTo assess whether implant failure rates in long term studies are matching the supposed high prevalence of peri‐implantitis.Material and MethodsThis paper is written as a narrative review of the long‐term clinical investigations available in the literature.ResultsSome implant systems have seen unacceptable marginal bone loss figures with time coupled to increased implant failure rates, resulting in the withdrawal of these systems. The reasons for such mishap are generally unknown, with the exception of one system failure that was found to be due to improper clinical handling. Modern, moderately rough implant systems have functioned excellently over 10–15 years of follow up with minor problems with marginal bone loss and implant failure rates within a few per cent. Machined implants have functioned adequately over 20–30 years of follow up. Implant failures occur predominantly during the first few years after implant placement. No significant increase of implant failures has been observed thereafter over 20–30 years of follow up.Over the years of our new millennium, scientific and technical advances have allowed the discovery of numerous molecular pathways and cellular interactions between the skeletal and immune system promoting the development of the interdisciplinary field called osteoimmunology. Nowadays, this knowledge has not only allowed the emergence of new etiologic paradigms for bone disease but also a new dynamic approach on the concept of osseointegration and MBL around oral implants, re‐evaluating our older disease oriented outlook. This facilitates at the same time the emergence of translational applications with immunological perspectives, scientific approaches based on omics sciences, and the beginning of an era of personalized dental implant therapy to improve the prognosis of oral implant treatment.ConclusionsOral implant systems have been found to function with very good clinical outcome over follow‐up times of 20–30 years. Registered implant failures have occurred predominantly during the first few years after implantation, and there has been no significant increase in late failures due to peri‐implantitis.
Medicolegal issues of peri‐anaesthetic dental injuries: A 21‐years review of liability lawsuits in France
Authors: Diakonoff Hadrien , De Rocquigny Gaël , Tourtier Jean‐Pierre , Guigon Aurore 
Published: May 2022

AbstractBackground/AimPeri‐anaesthetic dental injuries (PDI) represent a major source of potential malpractice claims against anesthesiologists. Studies about the medico‐legal aspects of PDI have mainly focused on liability insurance cases thus not encompassing those cases brought to court. The aim of this study was to assess the medico‐legal issues of PDI‐related liability lawsuits in France.Material and MethodsA review of judicial decisions pertaining to PDI was conducted on a French legal database, spanning the period between January 2000 and October 2021. Characteristics of decisions, patients and anesthesiologists, peri‐operative care, dental injuries, and convictions were collected when available for analysis.ResultsTwenty‐four judicial decisions fulfilled the inclusion criteria and were analyzed. All cases of dental injuries took place during elective surgery, 16 in the private sector and 8 in the public sector. Most injuries concerned two or more teeth and the most predominant dental injuries were luxation or avulsion (70.8% of cases). Eight cases resulted in a final verdict in favor of the plaintiff, four in the private sector (conviction rate: 25%), and four in the public sector (conviction rate: 50%). The causes of conviction were either a lack of information (5/8), a breach in the standard of care or technical negligence (3/8). The average amount of indemnification for the plaintiff was 3614 Euros (3753 Euros in 2022 inflation‐adjusted Euros) excluding legal fees.ConclusionsThe analysis of PDI‐related liability lawsuits shows that medico‐legal issues differ from those of PDI‐related insurance claims. Avulsion and luxation of multiple anterior teeth during elective surgery appear to be a risk factor for liability lawsuits. In addition, inadequacy of patient information about PDI‐risk seems to be a risk factor for conviction. Lastly, dental injuries are less at risk of civil conviction than other anesthesia‐related damages.
Prenatal reduction of E14.5 embryonically fate‐mapped pyramidal neurons in a mouse model of autism
Authors: Dufour Amandine , Dumon Camille , Gouty‐Colomer Laurie‐Anne , Eftekhari Sanaz , Ferrari Diana C. , Ben‐Ari Yehezkel 
Published: May 2022

AbstractAlthough several observations suggest that the constitutive biological, genetic or physiological changes leading to autism spectrum disorders (ASD) start in utero, their early impact on the number and density of neurons in the brain remains unknown. Using genetic fate mapping associated with the immunollabeling‐enabled three‐dimensional imaging of solvent‐cleared organs (iDISCO) clearing method we identified and counted a selective population of neocortical and hippocampal pyramidal neurons in the in utero valproate (VPA) mouse model of autism. We report that 1 day before birth, the number of pyramidal neurons born at E14.5 in the neocortex and hippocampus of VPA mice is smaller than in age‐matched controls. VPA also induced a reduction of the neocortical—but not hippocampal—volume 1 day before birth. Interestingly, VPA mice present an increase in both neocortical and hippocampal volumes 2 days after birth compared with controls. These results suggest that the VPA‐exposed hippocampus and neocortex differ substantially from controls during the highly complex perinatal period, and specially 1 day before birth, reflecting the early pathogenesis of ASD.
Early infantile epileptic encephalopathy related to NECAP1: Clinical delineation of the disease and review
Authors: Chouery Eliane , Mehawej Cybel , Sabbagh Sandra , Bleik Jamal , Megarbane Andre 
Published: May 2022

AbstractBackground and purposeEpileptic encephalopathy (EE) refers to a heterogeneous group of epilepsy syndromes characterized by seizures as well as encephalopathies, leading to cognitive and behavioral disturbances. These conditions vary in their age at onset, their severity, and their electroencephalographic patterns. Whereas genetic factors are involved in approximately 40% of all epilepsy cases, they contribute to 80% of early infantile EEs (EIEEs), with approximately 125 genes previously linked to this disease.MethodsWhole exome sequencing (WES) was performed in a 9‐month‐old Lebanese girl presenting with EIEE.ResultsWES enabled the detection of a homozygous missense mutation in the NECAP1 gene (NM_015509.3: p.Glu8Lys) in the proband.ConclusionsHere, we report the first homozygous missense mutation in the NECAP1 gene in a 9‐month‐old girl presenting with EIEE. Our findings allow a better characterization of the NECAP1‐linked disease and enable broadening its clinical spectrum by including, in addition to EIEE, severe generalized hypotonia, poor feeding, developmental delay, severe microcephaly, delayed myelination, abnormalities of the corpus callosum, and eye abnormalities.
Family functioning within the context of families with adolescent children in urban India
Authors: Hsieh Hsing‐Fang , Mistry Ritesh , Kleinsasser Michael J. , Puntambekar Namrata , Gupta Prakash C. , Raghunathan Trivellore , McCarthy William , Córdova David , Maharjan Gaurab , Desai Maruti B. , Narake Sameer , Pednekar Mangesh S. 
Published: May 2022

AbstractResearch on family functioning within given cultural contexts is needed. This study aims to describe salient dimensions of family functioning in two urban contexts in India and to examine differences in family functioning by sociodemographic groups. We measured differences in family functioning using cross‐sectional survey questionnaire data collected from 13 to 15‐year‐old adolescents and one of their parents/primary caregivers in Mumbai (n = 843) and Kolkata (n = 913) during 2019–2020. We drew a multi‐stage sample representative of neighborhoods and households in both cities. We assessed a multi‐dimensional family functioning latent factor that included parent‐reported measures (parent–adolescent communication, family cohesion, and parent monitoring of peers) and adolescent‐reported measures (parent support, family cohesion, and parent supervision). Our results support an overall measure of family functioning manifested by multiple dimensions for parent‐ and adolescent‐reported data. Families with male adolescents had worse adolescent‐reported family functioning in Mumbai and parent‐reported family functioning in Kolkata. Higher socioeconomic status was associated with better parent‐reported family functioning in both cities and better adolescent‐reported family functioning in Kolkata. Muslim religious identification in Kolkata and the Hindi native language in both cities were associated with better adolescent‐reported family functioning. Our findings indicate heterogeneity in family functioning across demographic and social‐cultural groups within the two urban contexts of India. This study may inform the development of culturally congruent prevention interventions for families with adolescents in India.
The nature of dispersal barriers and their impact on regional species pool richness and turnover
Authors: Nekola Jeffrey C. , Divíšek Jan , Horsák Michal 
Published: May 2022

AbstractAimWe document realized and potential global species ranges based on empirically vetted species concepts in conjunction with global climate databases and climate suitability modelling. From this we investigate the nature of dispersal barriers and illustrate how they generate ecological uniqueness.LocationHolarctic.MethodsFifty‐two small body‐size (i.e. < 5 mm) land snail taxa within the generaEuconulus,PupillaandVertigowere considered. These represent ~10% of all small body‐size Holarctic land snails and are among the most proficient known passive dispersers. Their potential climatic ranges were determined using Maxent modelling based on 9205 occurrence records. From these we inferred the location, width and nature of isolating barriers and tested for their effects on regional species pool richness and turnover.ResultsUse of unvetted traditional taxonomic concepts and unverified occurrence records would have created up to threefold higher or lower estimates of species‐specific climatic tolerances than the actual values. Modelling must thus only use high quality occurrence data. All but one taxon were shown at a global scale to possess multiple isolated areas of appropriate climate. While oceans represented the most common barrier (37%), intra‐continental barriers were in total almost twice as frequent (inappropriate climate – 29%, habitat/history – 27% and the Greenland ice sheet – 7%). These barriers restricted taxa to only a subset of their potential range, with European taxa possessing approximately twice the global occupancy rates as North American ones (median scores of 62 vs. 34%). As a result, regional taxa pools were three times smaller than their potential sizes, with 50% change in composition occurring over ~2600‐km distances.Main conclusionsEven for these readily dispersing taxa, isolation barriers prevented species from saturating their potential global range, reduced the size of regional species pools by 2/3, and generated ecological uniqueness between them.
Growth factor release and dental pulp stem cell attachment following dentine conditioning: An in vitro study
Authors: Sadaghiani Leili , Alshumrani Abdullah M. , Gleeson Hannah B. , Ayre Wayne Nishio , Sloan Alastair J. 
Published: May 2022

AbstractAimThe aim of the study was to investigate the effect of dentine conditioning agents on growth factor liberation and settlement of dental pulp progenitor cells (DPSCs) on dentine surfaces.MethodologyThe agents used included ethylenediaminetetraacetic acid (EDTA; 10%, pH 7.2), phosphoric acid (37%, pH < 1), citric acid (10%, pH 1.5) and polyacrylic acid (25%, pH 3.9). Human dentine slices were conditioned for exaggerated conditioning times of 5 and 10 min, so that the growth factor liberation reached quantifiable levels above the limit of detection of the laboratory methods employed. Transforming growth factor beta‐1 (TGF‐β1) release and surface exposure were quantified by enzyme‐linked immunosorbent assay (ELISA) and immunogold labelling. Scanning electron microscopy (SEM) was used to assess the morphology of cells and coverage by DPSCs cultured on dentine surfaces for 8 days.ResultsAfter 5‐min conditioning of dentine slices, citric acid was the most effective agent for growth factor release into the aqueous environment as measured by ELISA (Mann–Whitney U with Bonferroni correction, p < .01 compared with phosphoric and polyacrylic acid). As well as this, dentine slices treated with phosphoric acid for the same period, displayed significantly less TGF‐β1 on the surface compared with the other agents used, as measured by immunogold labelling (MWU with Bonferroni correction, p < .05). After 8 days, widespread coverage by DPSCs on dentine surfaces conditioned with citric acid and EDTA were evident under SEM. On dentine surfaces conditioned with phosphoric and polyacrylic acid, respectively, less spread cells and inconsistent cell coverage were observed.ConclusionsBased on the findings of this in vitro study, a desirable biological growth factor‐mediated effect may be gained when conditioning dentine by milder acidic or chelating agents such as citric acid and EDTA. The results must be interpreted in the context that the potential of the applied materials inducing a desirable biological response in DPSCs is only one consideration amongst other important ones in a clinical setting. However, it is crucial to look beyond the mere physical effects of materials and move towards biologically based treatment approaches as far as the restorative management of teeth with viable dental pulps are concerned.
Attachment styles and customers' long‐term relationships in a service context
Authors: Frydman Smadar , Tena Miguel Angel Moliner 
Published: May 2022

AbstractThe main objective of this study is to use attachment styles theory to explore long‐term relationships in a service context using the mobile market as a case study. Attachment theory focuses on the primary link between maternal loss or deprivation and later personality development. This theory was extended to adult life and commercial contexts. Three attachment styles (secure, avoidant, and anxious) were used as the independent variables. Commitment and trust, as constructs of any relationship, were employed as the mediating variables, while intention to stay and cooperation were adopted as the dependent variables, as indicators of long‐term commercial relationships. A random sample of 1024 members of an online panel participated in the online survey. Structural equation modelling was performed to measure the validity of the constructs through confirmatory factor analysis, and to assess the hypothesized model as a single theoretical structure using path analysis. Associations were found between most of the study variables. Significant mediation effects were found between attachment styles and long‐term relationship indicators, intention to stay, and cooperation, with trust and commitment as the mediators. This study employs a unique theoretical model that has not been previously tested. The model and findings demonstrate that primary psychological structures play a role in creating and maintaining long‐term relationships.
Repercusiones de la pandemia de COVID‐19 y del trabajo de cuidados no remunerado en los medios de vida de las trabajadoras y trabajadores informales
Authors: OGANDO Ana Carolina , ROGAN Michael , MOUSSIÉ Rachel 
Published: May 2022

ResumenCon datos de la primera ronda de un estudio longitudinal con métodos mixtos realizado en junio y julio de 2020 por la red WIEGO en colaboración con organizaciones de personas trabajadoras informales de doce ciudades, se evalúa el impacto de la actual crisis pandémica multidimensional (sanitaria, económica y de cuidados) en las responsabilidades de cuidado y el efecto resultante en los medios de vida y la seguridad alimentaria de personas trabajadoras informales de cuatro sectores. Un análisis de género del trabajo remunerado y del trabajo de cuidados no remunerado arroja luz sobre las características únicas del impacto de la actual recesión pandémica en la fuerza de trabajo informal del mundo.
COVID‐19 y crisis de los cuidados. Un análisis feminista de las políticas públicas en materia de trabajo doméstico y de cuidados remunerado y no remunerado
Authors: CAMILLETTI Elena , NESBITT‐AHMED Zahrah 
Published: May 2022

ResumenLa actual pandemia ha puesto de manifiesto las desigualdades de género haciendo aumentar los cuidados no remunerados que realizan las mujeres y las niñas y las vulnerabilidades de las cuidadoras remuneradas, a menudo mujeres que trabajan de manera informal. A partir de una base de datos mundial sobre políticas de protección social adoptadas frente a la COVID‐19 (asistencia social, seguros sociales y programas de mercado de trabajo), se examina si estas respuestas integran o no los cuidados y de qué forma. Se observa que algunas respuestas abordan los cuidados remunerados o no remunerados, pero muy pocas abordan ambos.
A Lifeline in troubled waters: A support intervention for migrant farm workers
Authors: Cohen Amy , Caxaj C. Susana 
Published: May 2022

AbstractWe implemented and evaluated a service delivery intervention (support model) to address the challenges faced by migrant agricultural workers in British Columbia, Canada. Three factors were identified that contributed to the effectiveness of the intervention: (1) face‐to‐face support and in‐person outreach towards connection; (2) accounting migrant workers' hierarchy of needs and addressing their basic needs first towards comprehensiveness; and (3) role clarity and communication between partners involved in supporting this population towards coordination. A final factor, wider constraints, referred to the wider context of migrant workers' lives including their temporary status, tied work permits, and lack of access to rights. These wider constraints, which were exacerbated by the COVID‐19 pandemic, underscore that until greater policy action is taken to address these workers' precarious status, support services can only offer a lifeline in troubled waters.