bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful single stage management of trifocal femoral fracture associated with distal medial condyle and Hoffa’s component by a novel technique
Authors: Rajamanya Kumardev Arvind , Marappa Girish 
Published: October 2022

<p>Isolated fractures of the shaft of the femur are relatively common injuries. Ipsilateral multifocal fractures of the femur are less common with an additional proximal femoral fracture estimated to occur in up to 5% of diaphyseal fractures and additional distal femoral fracture occurring in 3-4%. Trifocal femoral fractures consisting of ipsilateral fractures of the proximal, diaphyseal, and distal femur are extremely rare. These fracture patterns are seen in the young adult population following high velocity trauma such as fall from height and road traffic accidents. The sequence of fracture type to be fixed first and the type of implant to be used are questions yet to be answered as one implant used for fixation of one fracture may not be amenable for fixation of the other fracture. These fractures are associated with significant complications and delayed rehabilitation. We describe a novel method in one such trifocal fracture pattern where the distal femoral intra-articular medial condyle with a hoffas element was stabilised by open reduction with a 4.5 proximal tibial ipsi-lateral anterolateral LCP and 2 inter-fragmentary compression screws which has not been reported in literature before. The advantages of such an implant is easy contour ability to the medial femoral condyle and adequate strength and achieving satisfactory absolute stability with options of using uni-cortical locking screws, all of which facilitates early knee ROM and rehabilitation.</p><p> </p>
Systemic lupus erythematosus presenting with bullous lesions, cutaneous vasculitis and laryngeal ulcerations-a rare association
Authors: Pulletikurti Mrudula , Gopal K. V. T. , Raju P. V. Krishnam , Rani B. Rekha 
Published: October 2022

<p>Bullous SLE is an uncommon complication of SLE with autoantibodies to type VII collagen of dermo-epidermal junction. We report a 31-year-old female who presented with vesiculobullous lesions in the photo exposed areas along with vasculitic lesions over palms and soles and ulcerations in the larynx. She also had history of photosensitivity and hair loss. Investigations showed significant anaemia and high titres of antibodies (ANA, anti-ds-DNA, anti Sm) confirming SLE. Histopathology showing sub epidermal blister with neutrophils and immunofluorescence favoured diagnosis of bullous SLE. The patient responded well to high dose parenteral steroids and dapsone. In view of high probability of renal involvement, patient was referred to nephrologist and is under regular follow up.</p><p><strong> </strong></p><p> </p>
Effect of video- assisted teaching on knowledge regarding early detection and prevention of cervical cancer among women
Authors: Kumar Anu V 
Published: October 2022

Cancer is the second most common disease in India responsible for maximum mortality with about 0.3 million deaths per year. This is owing to the poor availability of prevention, diagnosis and treatment of the disease. Almost 9 out of 10 deaths occur from cervical cancer in less developed countries. Cancer of the cervix is largely preventable. The risk can be minimized by promotion of sexual risk reduction behavior and genital hygiene. Further prevention can be achieved by screening, using Visual Inspection with Acidic Acid (VIA) or Pap smear test, which can detect precancerous lesions early so as to prevent progress towards invasive cancer by timely treatment. A pre-experimental, One-group pre-test post-test design was undertaken for the study. 300 women were selected as the sample, Non- probability convenient sampling technique was utilized to select the sample from the population. After assessing knowledge video assisted teaching was implemented. After intervention on 7th day the post-test knowledge was assessed. Chi-square was used to measure the association of background variables of patients. ‘t’ test was used to assess the effectiveness of structured interventional programme of the patients. In the comparison between mean pretest and posttest knowledge score it is clear that during the pretest the knowledge score was poor (40%), fair ( 10%), good ( 40%) and excellent ( 10%), and after the administration of video assisted teaching, posttest was done and there was an improvement in the knowledge score of the female by poor (0%), fair (16.7%), good (23.3%) and excellent was( 60%), so there was a great difference in the knowledge score between the pre-test and posttest. The mean pretest knowledge score was 13.67 ± 7.66, while the posttest knowledge score was 23.80 ± 5.53 and the computed t value was found to be 19.105, The difference was found to be statistically significant. There will be significant association between the pretest knowledge score and selected demographic variables at the level of P≤ 0.05. is accepted as there is significant association between pretest knowledge score and selected demographic variables like religion, marital status, Age of women at marriage, no. of times they have conceived, methods of contraception’s, educational status, occupation, kinds of addiction, recurrent infections, history of cancer in family, previous information regarding cancer, history of pap test. The study recommended the utilization of video assisted teaching programme by community health nurses, nurse researchers, nurse administrators, nurse educators and health care professionals to improve knowledge of early detection of cervical cancer.
Pemanfaatan Limbah Kultur Batch Bioreaktor dan Biochar untuk Meningkatkan Kesuburan Tanah
Authors: Zaitun Zaitun , Halim Agus , Rahya Sufriyadi 
Published: October 2022

The purpose of study was to determine the effects of aeration treatment on fish wastewater quality as a liquid organic fertilizer and fish wastewater watering treatment as a liquid organic fertilizer and a biochar application on nutrient content of lettuce and soil chemical properties. This study used a non factorial randomized block design. Treatments combination were watering freshwater frequency (W0: without watering; W1: watering twice a week; and W2: watering 4 times a week) and rice husk biochar dose (B0: without rice husk biochar; B1: 10 g rice husk biochar per polybag; and B2: 20 g rice husk biochar per polybag). The research parameters included: fish culture wastewater quality (pH, Biological Oxygen Demand, Chemical Oxygen Demand, NH3-N, NO3, NO2, Dissolved Oxygen, electrical conductivity, and temperature), plant nutrient content analysis (N, P, and K), and soil chemical analysis (pH, organic C, total N, C/N ratio, available P, and exchangeable K). The results showed that the quality of wastewater after aeration for 4 days met the water criteria to cultivate plants. The nutrient contents in the soil showed criteria for neutral soil pH, very low organic C, very low total N, medium C/N ratio, very high available P, and low exchangeable K. Although the nutrient content in the soil was low, the concentrations of N (1.87-3.08%), P (0.16-0.21%), and K (2.35-3.43%) nutrients in the plant were sufficient for lettuce growth. The combination treatment of watering wastewater 4 times a week and rice husk biochar 20 g per polybag gave better results to increase soil fertility and lettuce plant nutrients.

Keywords: liquid waste, plant nutrients, soil amendment, soil chemistry
Effective Behavior of Insects Pollinators of Flowers in Gadung Mango Clone 21 Variety
Authors: Kusuma Ramadhani Mahendra , Windriyanti Wiwin 
Published: October 2022

Pollinating insects are referred as support services, namely services by the processes in the ecosystems that support human well-being by maintaining or enhancing ecosystem services. The availability of flowers, diversity, and behavior of visiting pollinator insects affect the effectiveness of pollination to increase the formation of fruit sets of mango plants. The purpose of this study is to observe the behavior of pollinator insects visiting the mango gadung clone 21 varieties and their effectiveness in increasing the formation of fruit sets. Research has been carried out on two flower seasons: March-May (Off season) and July-September (On season) 2020. Visiting behaviors observed were the number of visits per minute (foraging rate) and the length of visit per flower (flower handling time). Pollination effectiveness was measured from the number of fruit sets formed from the open flower panicles and confined with a tangerine gauze. The results of the study obtained seven species including Apis sp., Trigona sp., Xylocopa sp., Polistes sp. 1, Polistes sp. 2, Chrysomya sp., and Eristalis sp. Visits of pollinating insects on the highest number of mango panicle flowers were (31.69 ± 7.69) flowers / 60 seconds by Trigona sp insects, and the lowest numbers were (2.70 ± 0.67) flowers / 60 seconds by Eristalis sp. insects. The longest visits of pollinator insects on mango flowers were obtained by Eristalis sp for (25.3 ± 8.50) sec/individual/flower and the shortest visits were by Trigona sp for (1.8 ± 0.63) seconds/individual/flower. Insect pollination increases fruit formation by 267.5%. Keywords: insect visits, pollinating insects, fruit formation, gadung 21 varieties mango
Pengaruh Curah Hujan pada Produksi Padi Gogo di Indonesia
Authors: Santoso Agung Budi , Supriana Tavi , Girsang Moral Abadi 
Published: October 2022

Upland rice has high potential development that causes the potential of dry land in Indonesia is quite large. However, the productivity of upland rice and its contribution to national paddy production is still low. Upland rice mostly is cultivated based on rainfall so productivity of upland rice depends on fluctuation of rainfall at the area. Theoretically, Indonesia has three different rainfall types, namely; equatorial, monsoonal, and local. This study aimed to identify the effect of rainfall on upland rice production. This study used secondary data consisted of upland rice yield, precipitation, and harvested area in 1990–2017. Data were analyzed by quadratic nonlinear regression and then It was analyzed by Mann-Whitney different test. Selected location were North Sumatera Province, West Kalimantan, Central Sulawesi, East Java, South Sulawesi, South Kalimantan, and Maluku. Results show that three rainfall area types statistically differences. Precipitation at Equatorial area influences upland rice yield by 3.15 tons. Furthermore, precipitation at monsoon and local area have effects on reducing production by -0.17 ton and -10.66 ton respectively. Keywords: nonlinear regression, precipitation, productivity, upland rice
Kripkenstein from the mathematical point of view: a preliminary survey
Authors: Janik Bartosz 
Published: October 2022

This paper deals with the problem of the impact of Kripke’s skeptical paradox on the philosophy of mathematics. By perceiving mathematics as a huge rule-following discipline, one could argue that the Kripkean non-factualist thesis should be adopted within the philosophy of mathematics en bloc to imply a refutation of objectivity and an enforcement of a particular view on the nature of mathematics. In this paper I will discuss this claim. According to Kripke’s skeptical solution we should reject the notion of fact and adopt the use theory of meaning that could be stated as follows: ’One understands the concepts embodied in a language to the extent that one knows how to use the language correctly.’ [Shapiro 1991, 211] [Kripke 1982]. Focusing on mathematical discourse, we should ask: what are the implications of the use theory of meaning for the philosophy of mathematics? Furthermore, is the answer to the skeptical paradox consistent with selected views in philosophy of mathematics? The supposed answer to the first question is that it demands the view that mathematics should be perceived as a strictly pragmatic discipline and the rules of mathematical discourse are mere conventions. But this is too simplistic a view and the matter at hand is far more complicated.
The Ordovician Retroarc Foreland Basin on the Yangtze Block Linked to the Final Assemblage of Gondwana
Authors: Tang Hao , Xu Qiang , Li Shuangjian , Li Ling , Wang Xiaofang , Tan Xiucheng , Zheng Jianfeng , Kershaw Stephen , Yang Xuefei 
Published: October 2022

Abstract
Amalgamation of the Yangtze and Cathaysia blocks in the context of Gondwana assembly in the early Paleozoic has been addressed for decades, but the far-field effects on the Yangtze Block during the amalgamation remain unclear. In this study, we outline the sequence stratigraphic framework of the Ordovician succession in the central-upper Yangtze Block and analyze provenance records in sandstone compositions, distributions, and detritus zircon U-Pb dating. The Ordovician succession in the central-upper Yangtze Block is subdivided into six third-order sequences, which were deposited mainly in a carbonate platform with restricted sediments in Tremadocian to early Floian stages, mixed terrigenous-carbonate deposits in mid- to late Floian stages, and open circulation sediments in Dapingian to middle Katian stages. These sequences show the central-upper Yangtze Block experienced syn-tectonic deformation with northeast-trending long-wavelength uplift and depression alternatively and the depocenter shifting from the east during Tremadocian to mid-Floian stages to the southwest in late Floian to early Hirnantian stages. Provenance data indicate that detritus in the Ordovician succession was mainly from the northern India and Kangdian paleohighland to the southwest of South China Block. Incorporating the depositional and deformation variations, we propose a retroarc foreland basin that was developed on the South China Block in response to final suturing between the South China Block and East Gondwana at Sanya suture zone. The South China Block was thus involved in the global tectonics of the Gondwana supercontinental cycle during the Ordovician.
Secure Comparisons of Single Nucleotide
Polymorphisms Using Secure Multiparty
Computation
Authors: Woods Andrew , Kramer Skyler , Xu Dong , Jiang Wei 
Published: October 2022

Abstract
While genomic variations can provide valuable information for healthcare and ancestry, the privacy of individual genomic data must be protected. Thus, a secure environment is desirable for a human DNA database such that the total data are queryable but not directly accessible to involved parties (e.g., data hosts and hospitals) and that the query results are learned only by the user or authorized party. In this work, we provide efficient and secure computations on panels of single nucleotide polymorphisms (SNPs) from genomic sequences as computed under the following set operations: union, intersection, set difference, and symmetric difference. Using these operations, we can compute similarity metrics, such as the Jaccard similarity, which could allow querying a DNA database to find the same person and genetic relatives securely. We analyze various security paradigms and show metrics for the protocols under several security assumptions such as semi-honest, malicious with honest majority, and malicious with a malicious majority. We show that our methods can be used practically on realistically sized data. Specifically, we can compute the Jaccard similarity of two SNP panels, each with 400k SNPs, in 2.16 seconds with the assumption of a malicious adversary in an honest majority and 0.36 seconds under a semi-honest model. Our methods may help adopt trusted environments for hosting individual genomic data with end-to-end data security.
1
The Improved Pix2pix Generative Adversarial Networks for Sand-dust Image Enhancement
Authors: Hua Zhongwei , Qi Lizhe , Yang Zhi , Sun Yunquan 
Published: October 2022

Abstract

The frequent sand-dust weather in inland areas has severely affected the local outdoor computer vision applications. Different from the previous ideas of the sand-dust image enhancement algorithm, this paper proposes a generative adversarial network to enhance the sand-dust images. We improve the classic pix2pix network by introducing the dual attention mechanism to the U-net architecture and improve the loss function of the generator through Smooth L1 and SSIM to further enhance the color reproduction, detail features, the structural similarity, and the convergence speed of the generator. In addition, we also publish the first artificially synthesized sand-dust image data set online. The experimental results show that the enhancement method proposed in this paper has obvious advantages in both artificially synthesized images and natural real images, compared with the current traditional sand-dust enhancement algorithms and the previous network models.
TRANSPORT OF BROMIDE UNDER FIVE STEADY STATE WATER FLOW RATES AND THREE SOIL DEPTH: FIELD EXPERIMENT IN MOLISOL SOIL
Authors: Aparicio Virginia , Costa José Luis , Gimenez Daniel 
Published: October 2022

Abstract
The simulation of solute transport with models provides a cost-effective and rapid assessment tool. However, both model selection and its parameterization using data obtained from field-scale experiments, it is essential to obtain useful and accurate results. In our work under field conditions, we obtained bromide concentration data of soil water samples from three depths and five water flows to adjust 180 breakthrough curves for estimating solute transport parameters in soil: V, D and dispersivity (λ) and we checked the effect of three previous N treatments in these solute transport parameters. The velocity and dispersion parameters were fitted using the CXTFIT 2.1 model. After selecting the best model using Akaike criteria, we analyzed the distribution of transport parameters estimated using a normality test. The transport parameters were analyzed considering each water flow as a locality, prior fertilization treatments (0N, 100N and 200N) and depth (100, 150 and 190cm respectively) as a repeated measure in space using SAS 9.2. The MIM was the best model to fit the data of relative concentration of Br integrating the soil profile compared to CD and CLT models. In general, transport parameters obtained from adjustment breakthrough curves 180 have a normal distribution. In the analysis of the transport parameters, the velocity was seen to be statistically different between water flows, while the dispersion varied both between flows and between sampling depths and prior fertility treatment. The overall average of the mobile water fraction β was 0.35, indicating preferential flow. The soil structure and the physical non-steady state had a greater impact on the movement of solutes at depth than the steady state. The logarithm of the dispersivity differed statistically by flow and by depth.
Advanced glycation end products inhibit the osteogenic differentiation potential of adipose‐derived stem cells in mice through autophagy
Authors: Fu Ting , Lou Fangzhi , Zhu Qiang , Cai Shuyu , Peng Shuanglin , Xiao Jingang 
Published: October 2022

Abstract
Diabetes microenvironment will accelerate the accumulation of Advanced glycation end products (AGEs), therefore, AGEs are a signature product in the study of the diabetes microenvironment. Adipose-derived stem cells (ASCs) have poor osteogenesis in the diabetes microenvironment, but the mechanism of the altered osteogenic potential of ASCs has not been elucidated. Bone tissue engineering by ASCs is widely used in the treatment of bone defects with diabetic osteoporosis. Therefore, this study investigated the effects of AGEs on osteogenic differentiation potential of ASCs and the underlying mechanisms. In the present study, we isolated and cultured ASCs in C57BL/6 mice, then treated ASCs with AGEs, the levels of autophagy and osteogenesis-related factors were decreased in the AGE-treated group. In order to verify autophagy and AGE-mediated changes in the osteogenic capacity of ASCs, we used 3-methyladenine, and rapamycin. After cotreatment with 3-methyladenine and AGEs, the levels of osteogenesis and autophagy were reduced more significantly, whereas rapamycin ameliorated the autophagy level and osteogenic differentiation potential of ASCs treated with AGEs. This study shows that AGEs can reduce the osteogenic differentiation potential of ASCs through autophagy, which may provide a reference for the treatment of bone defects with diabetes osteoporosis.
The agonist of adenosine A1 receptor induced desensitization of delta opioid receptor-mediated Raf-1/MEK/ERK signaling by feedback phosphorylation of Raf-1-Ser289/296/301
Authors: Xu Chi , Cheng Yun , Tao Yimin , Liu Jing-Gen 
Published: October 2022

Abstract
Our previous study found that activation of adenosine A1 receptor (A1R) induced phosphorylation of delta opioid receptor (DOR) and desensitization of its downstream signaling molecules, cAMP and Akt. To further investigate the effect of A1R agonist on DOR signaling and the underlying mechanism, we examined the effect of A1R activation upon binding of its agonist CHA on DOR-mediated Raf-1/MEK/ERK activation, and found that prolonged CHA exposure resulted in downregulation of DOR-mediated Raf-1/MEK/ERK signaling pathway. CHA-treatment time dependently attenuated DPDPE-induced phosphorylation of Raf-1-Ser338, which further caused downregulation of the Raf-1/MEK/ERK signaling pathway activated by DOR agonist. Moreover, CHA exposure time-dependently induced the phosphorylation of Raf-1-Ser289/296/301, the inhibitory phosphorylation sites that were regulated by negative feedback, thereby inhibiting activation of the MEK/ERK pathway, and this effect could be blocked by MEK inhibitor U0126. Finally, we proved that the heterologous desensitization of the Raf-1/MEK/ERK cascade was essential in the regulation of anti-nociceptive effect of DOR agonists by confirming that such effect was inhibited by pretreatment of CHA. Therefore, we conclude that the activation of A1R inhibits DOR-mediated MAPK signaling pathway via heterologous desensitization of the Raf-1/MEK/ERK cascade, which is a result of ERK-mediated Raf-1-Ser289/296/301 phosphorylation mediated by activation of A1R.
Achieving permanent transplant tolerance via reverse chimeras in orthotopic liver transplantation
Authors: Tang gaofeng , zhao huibo , Chen Guoyong 
Published: October 2022

Abstract
The severe side-effects and toxicities associated with lifelong immunosuppression after organ transplantation necessitate the quest for immunological tolerance, it is a durable immunosuppression-free state in which the transplanted allograft functions well without chronic rejection occurrence, and there is no transplant tolerance protocol available clinically. Here we show that this tolerance, during the transition from hypertrophy to hyperplasia upon liver regeneration, is acquired early and maintained permanently in orthotopic rat half-size liver transplantation (LT) while host bone marrow stem cells are mobilized and short-course immunosuppression is administered. Compared with whole and half-size LT as controls, survival for more than 500 days was observed in tolerant rats, the liver allograft worked better and its microstructures remained normal without chronic rejection. Sex-mismatch LT revealed that the host bone marrow stem cells repopulated the allograft to create reverse chimeras with host Y chromosomes in female donor livers and the increased host to donor ratio over time. However, a donor specific hyporesponse was not achieved through skin transplantation and skin allograft challenge did not elicit the rejection of liver allografts. Our finding that transplant tolerance achieved via reverse chimeras bypasses the complex immune system simplifies its induction clinically and facilitates its translation and application in human