bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing TQM’s effect on small business performance: a PLS-SEM exploratory study of TQM applied with a comprehensive strategic approach
Authors: Manley Scott C. , Williams Jr. Ralph I. , Hair Jr. Joseph F. 
Published: September 2022

PurposeGiven the positive organizational principles associated with total quality management (TQM) – customer focus, continuous improvement, and process management – one would assume TQM's application is universally beneficial across businesses. Generally, research supports that notion. However, given resource limitations and shallow management teams in small businesses, there are multiple challenges in implementing TQM in small and medium-sized enterprises (SMEs). Therefore, small business leaders should benefit from knowledge linking other management practices to TQM’s positive effect on small firm performance, which enhances these leaders' return on TQM investment.Design/methodology/approachThe authors apply partial least squares structural equation modeling (PLS-SEM) to explore TQM’s effect on small business performance and how other management practices enhance that relationship. Specifically, the authors explore how a comprehensive strategic approach (CSA) – a higher-order construct consisting of strategic planning, goal setting, and financial ratio analysis – moderates the relationship between TQM and small business performance. Given the complexity of the authors' model, the application of higher-order constructs, and the exploratory nature of this work, PLS-SEM is well suited for this study.FindingsConsistent with prior research, the authors found that TQM (also a higher-order construct, consisting of seven lower-order constructs) positively impacts small firm performance. In addition, the authors found that CSA positively moderates the relationship between TQM and financial performance.Originality/valueTQM’s effect on small business performance is enhanced when leaders implement a CSA. In other words, when small business leaders strategically plan, set goals, and analyze financial ratios, TQM's positive effect on firm performance is enhanced. This finding provides business leaders insights for how to maximize the TQM investment return.
Approaches to decomposing acoustic data
Authors: Haldorsen Jakob B.U. 
Published: September 2022

AbstractThis note compares different approaches to estimating acoustic plane‐wave components from a set of traces recorded by receivers at known locations. The parameters for these plane waves are estimated following somewhat different approaches:

A heuristic approach without reference to any optimization schemes).
A frequency‐domain least‐squares approach:

With explicit derivation of separate real and imaginary parts of the complex‐valued wave‐field parameters.
Using complex partial differential operators.

All approaches give the same solution. Of the three, the first approach gives a better understanding of the physics – the last approach is far more direct and easier. That the results are identical argues for our use of Wirtinger complex partial differential operators for our least‐squares minimization problem. Using these operators allows the complex numbers z and to be considered independent variables, giving .
Gender diversities and sex education
Authors: Mayo Cris 
Published: September 2022

Abstract
This article suggests that science-based understandings of sex and gender can improve sex education by inviting students to consider what sex and gender mean and by encouraging recognition and respect in a gender-diverse context. In addition, decolonising approaches to gender provide another route to sexuality education that is more attendant to difference and diversity, helping students to see how culturally embedded and resistant meanings and practices have shaped understandings of gender. Together, these divergent approaches—gender science and decolonising education—provide an array of conceptual links between gender identity and other forms of innovation and reclamation. Such tactics of conceptual connection may help sex education to think about gender in different ways, some of which invite gender-diverse students into the curriculum and some of which invite normatively gendered students to consider their own complexities. Using these tactics of conceptual linkage encourages educators and students to develop a fuller vocabulary for addressing how gender, sexuality and struggles over meaning can be a core part of sex education. By thinking and teaching more carefully about the diversities related to key concepts like gender, sex education can both critically examine inequities and aim towards the possibilities of gender diversity.
Can responsibility attributions be sensible in the presence of partisan‐motivated reasoning?
Authors: TROMBORG MATHIAS WESSEL 
Published: September 2022

AbstractPolitical accountability requires that voters understand the distribution of policy outcome responsibility among their vote choice options. Research on partisan‐motivated reasoning suggests that voters do not meet this requirement. The problem is that voters condition their attributions of responsibility to the government on their party identification. Government identifiers credit the government for desirable outcomes and blame external forces such as the global economy for undesirable outcomes. This paper draws a more optimistic conclusion. It argues that focusing on the perceived responsibility of the government and external forces is not sufficient for understanding whether voters meet the responsibility attribution requirement. It is also necessary to compare the perceived responsibility of government parties to the perceived responsibility of opposition parties because those are the options that voters get to choose from. This party distribution of perceived responsibility is analyzed with original survey data from Denmark and the United Kingdom. The results demonstrate that while party identification does indeed condition voters’ responsibility attributions, both government identifiers and independents attribute systematically more responsibility to the government than to the opposition regardless of the desirability of the outcome. This suggests that voters tend to meet the responsibility attribution requirement of accountability despite the presence of partisan‐motivated reasoning.
Commentary on CDC data showing an increased risk for pediatric diabetes with COVID‐19 infection
Authors: Gujral Jasmine , Tamborlane William , Nally Laura 
Published: September 2022

Highlights
We question certain aspects of the recent Centers for Disease Control and Prevention (CDC) Morbidity and Mortality Weekly Report (January 2022) showing a significant increase in the incidence of diabetes in children after COVID‐19 infection.
We are concerned at the source of data being limited to commercial health insurances and lack of factoring race, ethnicity, social determinants of health, body mass index, type of diabetes, and viral variants in the interpretation of these data.
#TurntTrending: a systematic review of substance use portrayals on social media platforms
Authors: Rutherford Brienna N. , Lim Carmen C. W. , Johnson Benjamin , Cheng Brandon , Chung Jack , Huang Sandy , Sun Tianze , Leung Janni , Stjepanović Daniel , Chan Gary C. K. 
Published: September 2022

AbstractAimsThere is a growing body of literature exploring the types of substance‐related content and their portrayals on various social media platforms. We aimed to summarize how content related to substances is portrayed on various social media platforms.MethodsThis systematic review was pre‐registered on PROSPERO (ref: CRD42021291853). A comprehensive search was conducted in the databases of PubMed, Scopus, PsycINFO and Web of Science in April 2021. Original qualitative studies published post‐2004 that included thematic and sentiment analyses of social media content on tobacco, alcohol, psychostimulant, e‐cigarette, cannabis, opiate, stimulant/amphetamine, inhalant and novel psychoactive substance were included. Social media platforms were defined as online web‐ or application‐based platforms that allowed users to generate content and interact via ‘liking’, comment or messaging features. Only studies that included summative and/or thematic content analyses of substance‐related social media content were included.ResultsA total of 73 studies, which covered 15 905 182 substance‐related posts on Twitter, YouTube, Instagram, Pinterest, TikTok and Weibo, were identified. A total of 76.3% of all substance‐related content was positive in its depiction of substance use, with 20.2% of content depicting use negatively. Sentiment regarding opiate use however was commonly negative (55.5%). Most studies identified themes relating to Health, Safety and Harms (65.0%) of substance use. Themes relating to Promotions/Advertisements (63.3%), Informative content (55.0%) and Use behaviours (43.3%) were also frequently identified.ConclusionsSubstance‐related content that promotes engagement with substance use or actively depicts use appears to be widely available on social media. The large public presence of this content may have concerning influences on attitudes, behaviours and risk perceptions relating to substance use, particularly among the most vulnerable and heaviest users of social media—adolescents and young adults.
A call for increased addiction psychiatrist engagement in medical student education
Authors: Balasanova Alëna A. , Ritvo Alexis , Renner John A. 
Published: September 2022

AbstractBackground and ObjectivesAddiction psychiatrists are ideally trained to provide trainees with supervised clinical experiences in caring for patients with co‐occurring substance use disorders and other complex psychiatric disorders.MethodsThis is a call for addiction psychiatrists to step up as clinical champions in medical student education. Our targeted audience is practicing addiction psychiatrists who do not currently have medical students on their clinical services.ResultsWe suggest several approaches to incorporating learners into existing addiction psychiatry clinical services both at academic institutions and in the community.Discussion and ConclusionsFor medical schools without addiction psychiatrists on faculty, we suggest unique solutions for collaborating with external educational venues.Scientific SignificanceThere is limited literature on the role of addiction psychiatrists in providing supervised experiential learning experiences for medical students. There has been no previous publication specifically advocating for increased addiction psychiatrist engagement in the clinical education of medical students.
Slavery, Colonialism, and Ecological Imperialism: Insights from Stratification Economics
Authors: Goubert Anaïs E. A. 
Published: September 2022

AbstractBlack and Indigenous people in the United States have already begun to disproportionately suffer from the detrimental effects of climate change. Understanding how to address these disproportionate climate vulnerabilities can most potently be done through the lens of stratification economics. The persistent racial wealth gap is a reflection of the racist history of the United States, especially the legacies of slavery and settler colonialism. In addition, that racial history helps explain how Black people have become particularly susceptible to the climate crises. This article offers theoretical outlines to explain and, potentially, resolve ecological imperialism in the United States.
Metabolic and magnetic resonance imaging: complementary modalities for the preoperative assessment of lateral pelvic lymph nodes in rectal cancer
Authors: Cribb Benjamin I. , Kong Joseph C. , Kay James S. , Tan Teng H. , Noe Geertje D. , Gest Bibiche , Lee Allan B. , Oon Sheng F. , Warrier Satish K. , Heriot Alexander G. 
Published: September 2022

AbstractBackgroundThe management of lateral pelvic lymph nodes for rectal cancer is a topical and controversial issue. The aim of this study was to assess the relationship between lateral pelvic lymph node features on magnetic resonance imaging (MRI) and positron emission tomography‐computed tomography (PET‐CT) with oncological outcomes in patients with rectal cancer.MethodsA retrospective analysis of 284 patients with primary locally advanced rectal cancer treated with neoadjuvant therapy and surgical resection with curative intent between January 2003 and Dec 2018 was undertaken. From this study population, a select cohort of 77 patients with abnormal lateral pelvic lymph nodes on preoperative imaging had imaging re‐analysed by radiologists blinded to clinical outcomes. Pre and post neoadjuvant therapy MRI and PET‐CT lateral pelvic lymph node features were correlated with oncological outcomes.ResultsA lateral pelvic lymph node short axis size ≥5 mm on post neoadjuvant therapy MRI was a significant predictor of worse 3‐year local recurrence free survival (HR 8.35, P = 0.001). Lateral pelvic lymph node avidity on post neoadjuvant therapy PET‐CT was a significant predictor of worse 3‐year distant recurrence free survival (HR 5.62, P = 0.001).No correlation of oncological outcomes with overall survival was identified.ConclusionLateral pelvic lymph node imaging features on post‐neoadjuvant therapy MRI and PET‐CT predicted those at risk of rectal cancer recurrence. Further studies are required to confirm these findings that suggest restaging MRI and PET‐CT are complementary modalities for the preoperative assessment of lateral pelvic lymph nodes in rectal cancer.
Automated detection of hyperreflective foci in the outer nuclear layer of the retina
Authors: Schmidt Mathias Falck , Christensen Jakob Lønborg , Dahl Vedrana Andersen , Toosy Ahmed , Petzold Axel , Hanson James V. M. , Schippling Sven , Frederiksen Jette Lautrup , Larsen Michael 
Published: September 2022

AbstractPurposeHyperreflective foci are poorly understood transient elements seen on optical coherence tomography (OCT) of the retina in both healthy and diseased eyes. Systematic studies may benefit from the development of automated tools that can map and track such foci. The outer nuclear layer (ONL) of the retina is an attractive layer in which to study hyperreflective foci as it has no fixed hyperreflective elements in healthy eyes. In this study, we intended to evaluate whether automated image analysis can identify, quantify and visualize hyperreflective foci in the ONL of the retina.MethodsThis longitudinal exploratory study investigated 14 eyes of seven patients including six patients with optic neuropathy and one with mild non‐proliferative diabetic retinopathy. In total, 2596 OCT B‐scan were obtained. An image analysis blob detector algorithm was used to detect candidate foci, and a convolutional neural network (CNN) trained on a manually labelled subset of data was then used to select those candidate foci in the ONL that fitted the characteristics of the reference foci best.ResultsIn the manually labelled data set, the blob detector found 2548 candidate foci, correctly detecting 350 (89%) out of 391 manually labelled reference foci. The accuracy of CNN classifier was assessed by manually splitting the 2548 candidate foci into a training and validation set. On the validation set, the classifier obtained an accuracy of 96.3%, a sensitivity of 88.4% and a specificity of 97.5% (AUC 0.989).ConclusionThis study demonstrated that automated image analysis and machine learning methods can be used to successfully identify, quantify and visualize hyperreflective foci in the ONL of the retina on OCT scans.
Brainstem noradrenergic neurons: Identifying a hub at the intersection of cognition, motility, and skeletal muscle regulation
Authors: Delbono Osvaldo , Wang Zhong‐Min , Messi María Laura 
Published: September 2022

AbstractBrainstem noradrenergic neuron clusters form a node integrating efferents projecting to distinct areas such as those regulating cognition and skeletal muscle structure and function, and receive dissimilar afferents through established circuits to coordinate organismal responses to internal and environmental challenges. Genetic lineage tracing shows the remarkable heterogeneity of brainstem noradrenergic neurons, which may explain their varied functions. They project to the locus coeruleus, the primary source of noradrenaline in the brain, which supports learning and cognition. They also project to pre‐ganglionic neurons, which lie within the spinal cord and form synapses onto post‐ganglionic neurons. The synapse between descending brainstem noradrenergic neurons and pre‐ganglionic spinal neurons, and these in turn with post‐ganglionic noradrenergic neurons located at the paravertebral sympathetic ganglia, support an anatomical hierarchy that regulates skeletal muscle innervation, neuromuscular transmission, and muscle trophism. Whether any noradrenergic neuron subpopulation is more susceptible to damaged protein deposit and death with ageing and neurodegeneration is a relevant question that answer will help us to detect neurodegeneration at an early stage, establish prognosis, and anticipate disease progression. Loss of muscle mass and strength with ageing, termedsarcopenia, may predict impaired cognition with ageing and neurodegeneration and establish an early time to start interventions aimed at reducing central noradrenergic neurons hyperactivity. Complex multidisciplinary approaches, including genetic tracing, specific circuit labelling, optogenetics and chemogenetics, electrophysiology, and single‐cell transcriptomics and proteomics, are required to test this hypothesis pre‐clinical.
Letter: efficacy of peppermint oil in irritable bowel syndrome—authors' reply
Authors: Ingrosso Maria Rosa , Ianiro Gianluca , Nee Judy , Lembo Anthony J. , Moayyedi Paul , Black Christopher J. , Ford Alexander C. 
Published: September 2022

LINKED CONTENTThis article is linked to Ingrosso et al papers. To view these articles, visit https://doi.org/10.1111/apt.17179 and https://doi.org/10.1111/apt.17194
Basin analysis palaeo‐landscape modelling: Testing the critical controls using experimental design constrained by a real 3D geological model, Gippsland Basin, Australia
Authors: Yang Xuemei , Smith Gregory , Gupta Ritu 
Published: September 2022

AbstractThe main controlling variables for palaeo‐landscape evolution are investigated to assess their relative importance using the Gippsland Basin geological history. Palaeo‐landscape reconstruction is a complicated process controlled and affected by multiple variables, including tectonic, palaeo‐environment, sea‐level change, rainfall, sediment erosion, transportation, deposition, etc. The Basin and Landscape Dynamics software (Badlands) software was used with an efficient experimental design (ED) to guide the selected scenarios, process the results, and generate the multi‐variate equations that define and identify the important controlling variables. The ED was used to test and identify the main uncertainties and their possible ranges, based on actual field data, while at the same time ensuring that the full multi‐dimensional space for those variables was covered to enable the computation of multivariate equations from the minimum number of scenario runs. A full suite of 3D forward palaeo‐landscape models of the Gippsland Basin was built to reconstruct the basin history from its formation to the present (Early Cretaceous to Holocene, 137‐0 Ma). The models are compared to the corresponding full 3D realistic structural and stratigraphic model of the basin that has been built in Petrel (Schlumberger software). This constrains the sedimentary, stratigraphic, burial and thermal histories to the relative subsidence rates and basin‐fill for each geological sequence by using the model isopachs input to the Badlands modelling. The ED required only 22 scenarios to fit 12 identified variables and test for possible interactions with each other. The most significant variables are those that control sediment supply including non‐marine erodibility, rainfall, (Rainfall × Area) exponent m, Slope and critical slope while maximum % Marine Deposition and marine dispersal are also required to fill the marine accommodation space. Sea Level and subsidence only become significant when rapid enough to outpace sediment supply. The controlling factors change over time with basin development from rift to post‐rift phases and interactions are highly significant.
TIMP1 promotes cell proliferation and invasion capability of right‐sided colon cancers via the FAK/Akt signaling pathway
Authors: Ma Beibei , Ueda Hiroyuki , Okamoto Koichi , Bando Masahiro , Fujimoto Shota , Okada Yasuyuki , Kawaguchi Tomoyuki , Wada Hironori , Miyamoto Hiroshi , Shimada Mitsuo , Sato Yasushi , Takayama Tetsuji 
Published: September 2022

AbstractAlthough right‐sided colorectal cancer (CRC) shows a worse prognosis than left‐sided CRC, the underlying mechanism remains unclear. We established patient‐derived organoids (PDOs) from left‐ and right‐sided CRCs and directly compared cell proliferation and invasion capability between them. We then analyzed the expression of numerous genes in signal transduction pathways to clarify the mechanism of the differential prognosis. Cell proliferation activity and invasion capability in right‐sided cancer PDOs were significantly higher than in left‐sided cancer PDOs and normal PDOs, as revealed by Cell Titer Glo and transwell assays, respectively. We then used quantitative RT‐PCR to compare 184 genes in 30 pathways among right‐sided and left‐sided cancer and normal PDOs and found that the TIMP1 mRNA level was highest in right‐sided PDOs. TIMP1 protein levels were upregulated in right‐sided PDOs compared with normal PDOs but was downregulated in left‐sided PDOs. TIMP1 knockdown with shRNA significantly decreased cell proliferation activity and invasion capability in right‐sided PDOs but not in left‐sided PDOs. Moreover, TIMP1 knockdown significantly decreased pFAK and pAkt expression levels in right‐sided PDOs but not in left‐sided PDOs. A database analysis of The Cancer Genome Atlas revealed that TIMP1 expression in right‐sided CRCs was significantly higher than in left‐sided CRCs. Kaplan–Meier survival analysis showed significantly shorter overall survival in high‐TIMP1 patients versus low‐TIMP1 patients with right‐sided CRCs but not left‐sided CRCs. Our data suggest that TIMP1 is overexpressed in right‐sided CRCs and promotes cell proliferation and invasion capability through the TIMP1/FAK/Akt pathway, leading to a poor prognosis. The TIMP1/FAK/Akt pathway can be a target for therapeutic agents in right‐sided CRCs.
The emerging multifaceted role of PINK1 in cancer biology
Authors: Wang Meng , Luan Shijia , Fan Xiang , Wang Jie , Huang Ju , Gao Xu , Han Dong 
Published: September 2022

AbstractFor its various important functions in cells, phosphatase and tensin homolog‐induced kinase 1 (PINK1) has drawn considerable attention for the role it plays in early‐onset Parkinson's disease. In recent years, emerging evidence has supported the hypothesis that PINK1 plays a part in regulating many physiological and pathophysiological processes in cancer cells, including cytoplasmic homeostasis, cell survival, and cell death. According to the findings of these studies, PINK1 can function as a tumor promoter or suppressor, showing a duality that is dependent on the context. In this study we review the mechanistic characters relating to PINK1 based on available published data from peer‐reviewed articles, The Cancer Genome Atlas data mining, and cell‐based assays. This mini review focuses on some of the interplays between PINK1 and the context and recent developments in the field, including its growing involvement in mitophagy and its nonmitophagy organelles‐related function. This review aims to help readers better grasp how PINK1 is functioning in cell physiological and pathophysiological processes, especially in cancer biology.