bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison between window traps and pan traps in monitoring flower-visiting insects in agricultural fields
Authors: Shi Xiaoyu , Fu Daomeng , Xiao Haijun , Hodgson Jenny A. , Yan Dongyue , Zou Yi 
Published: April 2022

AbstractSampling flower-visiting insects in agricultural fields at large spatial and temporal scales is significant for understanding local insect pollinator communities. The most commonly used method, pan trap, has been criticized due to its attractant bias. A window trap (also referred to as the flight-intercept trap) is a non-attractant sampling method, which has been applied in forests and grasslands, but rarely in agricultural fields. We aim to test whether we can replace pan traps with window traps in agricultural fields by comparing species richness and species composition between the two methods, and to show whether flower-visiting insects collected in both traps can reflect flower-visiting activity recorded by camera observation. We conducted a 2-year study to compare the performance of these sampling methods in an oilseed rape field. Results showed that the relative abundance of dominant flower-visiting species was highly correlated between the window trap and the pan trap samples, while window traps caught more individuals and higher (rarefied) species richness than pan traps. The species composition of window traps was more similar to each other than that of pan traps. The proportion of honey bees (Apis spp.) collected in both traps underestimated their flower-visiting activity recorded by camera observations, while sweat bees (Halictidae) and butterflies (Lepidoptera) were overestimated. Our study suggests that the window trap has the potential to serve as an alternative sampling method of flower-visiting insects to the pan trap. However, we need to be cautious when using specimens caught in both traps as a proxy of their flower-visiting activity.
Delivery of a trauma-focused CBT group for heterogeneous single-incident traumas in adult primary care: a follow-on case study
Authors: Skilbeck Lilian , Spanton Christopher 
Published: April 2022

Abstract
Group therapy for adult post-traumatic stress disorder (PTSD) has been a subject of debate over the past few years. A recent update on five international clinical practice guidelines on the use of group-therapy for PTSD in adults ranged from moderate support (e.g. the International Society for Traumatic Stress Studies) to no recommendation (e.g. the National Institute for Health and Care Excellence, NICE). However, a unanimous recommendation was that practitioners collaborated with their clients and weighed up the guidelines and client preferences to make the appropriate decisions. The current case study was guided by these recommendations. A minority of clients presenting to the service expressed a preference for group therapy for their PTSD symptoms. The current study follows on from a previous shared-trauma therapy group. It illustrates how the service took the NICE guidelines fully into account alongside the clients’ needs and preferences to deliver a NICE-compliant heterogenous trauma-focused CBT group. Twenty-four clients presenting with PTSD from different single-incident traumas opted for group therapy. Clients attended one of three 8-session trauma-focused CBT groups depending on preference (e.g. date/time, location). The groups were conducted face-to-face on a weekly basis. Seventeen clients completed treatment. Eleven clients no longer showed clinically important symptoms of PTSD as assessed on the PCL-5 and interview. This was sustained at 3-month follow-up. Four other clients showed reliable change. Two clients showed minimal improvement. This study is discussed with reference to opportunities, challenges and recommendations for clinical practice and research.

Key learning aims
It is hoped that the reader of this case study will increase their understanding of the following:

(1)
Delivery of a trauma-focused CBT group for heterogeneous single-incident traumas.

(2)
Taking full consideration of the NICE guidelines alongside the clients’ needs and preferences.

(3)
Guiding the focus of therapy on processing the trauma memory and its aftermath.

(4)
Effective use of group processes to facilitate outcomes.
On the Inference of Tsunami Uncertainties From Landslide Run‐Out Observations
Authors: Zengaffinen‐Morris T. , Urgeles R. , Løvholt F. 
Published: April 2022

AbstractProbabilistic tsunami hazard analysis (PTHA) due to submarine landslides is much less developed than PTHA for earthquake sources. This is partly because of less constrained data available for quantifying source probability, and partly because of the lack of knowledge related to the tsunami generation process due to landslide dynamics. This study provides a basis for estimating the uncertainty related to landslide dynamics for PTHA from submarine landslides based on a new landslide database in the Gulf of Cadiz. The establishment of this new database is described herein. We use submarine landslide run‐out statistics from this database to calibrate landslide parameters and related uncertainties employing the cohesive landslide model BingClaw. In turn, coupling the landslide motion to tsunami genesis is performed in order to characterize the inferred tsunami uncertainties. Important parameters that can explain the large tsunami uncertainties are the initial water depth of the landslide, the slope, the landslide volume, and the initial yield strength of the landslide material. Kinematic properties such as the initial landslide acceleration or the Froude number are found to strongly correlate with the tsunami‐genesis. In this study, we show how matching numerical landslide models with observed run‐out from past events in the field can give information about the uncertainty in their tsunami‐genic strength. This can in turn be applied in future PTHA for spanning uncertainty ranges due to the landslide dynamics on tsunami‐genesis, constrained by landslide run‐out data.
Design and optimization of metformin hydrophobic ion pairs for efficient encapsulation in polymeric drug carriers
Authors: Abd-El Hafeez Sara I. , Eleraky Nermin E. , Hafez Ehsan , Abouelmagd Sara A. 
Published: April 2022

AbstractLoading small molecular weight hydrophilic drugs into polymeric carriers is a challenging task. Metformin hydrochloride (MET) is a highly soluble oral antidiabetic drug of small size and high cationic charge. Hydrophobic ion pairing (HIP) is an approach for reversible modulation of solubility and hydrophilicity of water-soluble drugs via complexation with oppositely charged molecules. Herein, we prepared MET ion pairs and carefully studied and characterized MET interaction with different ligands, with the aim of increasing MET lipophilicity and loading efficiency. HIP was successful using three hydrophilic anionic ligands; sodium dodecyl sulphate (SDS) Carbopol (CB) and tannic acid (TA). Electrostatic interaction and hydrogen bonding drove the complexation per spectroscopic and thermal studies. Complexation efficiency depended on ligand type and charge ratio. While complexes had varying interaction strengths, the excessive stability of TA/MET resulted in unfavorable poor MET dissociation. Notably, HIP imparted a 450 and tenfold lipophilicity increase for SDS/MET and CB/MET, respectively. The latter showed favorable controlled, yet complete release of MET at pH 6.8 and was loaded into alginate beads. Complex bulkiness and decreased lipophilicity resulted in a dramatic 88% increase of MET loading, demonstrating the success of HIP as a simple, efficient and applicable approach for modulating drug’s properties.
Transcriptomic analysis of cumulus cells shows altered pathways in patients with minimal and mild endometriosis
Authors: Da Luz Caroline Mantovani , Da Broi Michele Gomes , Koopman Larissa de Oliveira , Plaça Jessica Rodrigues , da Silva-Jr Wilson Araújo , Ferriani Rui Alberto , Meola Juliana , Navarro Paula Andrea 
Published: April 2022

AbstractEndometriosis is a chronic inflammatory disorder that is highly associated with infertility. This association seems to be related to oocyte impairment, mainly in the initial stages of endometriosis (minimal and mild), where no distortions or adhesions are present. Nonetheless, invasive oocyte analyses are not routinely feasible; thus, indirect assessment of oocyte quality is highly desirable, and, in this context, cumulus cells (CCs) may be more suitable targets of analysis. CCs are crucial in oocyte development and could be used as an index of oocyte quality. Therefore, this prospective case–control study aimed to shed light on the infertility mechanisms of endometriosis I/II by analyzing the CCs’ mRNA transcription profile (women with endometriosis I/II, n = 9) compared to controls (women with tubal abnormalities or male factor, n = 9). The transcriptomic analyses of CCs from patients with minimal and mild endometriosis revealed 26 differentially expressed genes compared to the controls. The enrichment analysis evidenced some altered molecular processes: Cytokine-cytokine receptor interactions, Chemokine signaling, TNF signaling, NOD-like receptor signaling, NF-kappa B signaling, and inflammatory response. With the exception of CXCL12, all enriched genes were downregulated in CCs from patients with endometriosis. These findings provide a significant achievement in the field of reproductive biology, directing future studies to discover biomarkers of oocyte quality in endometriosis.
A register-based study on associations between pre-stroke physical activity and cognition early after stroke (part of PAPSIGOT)
Authors: Reinholdsson Malin , Abzhandadze Tamar , Palstam Annie , Sunnerhagen Katharina S. 
Published: April 2022

AbstractThe objective was to investigate if pre-stroke physical activity is associated with intact cognition early after stroke. The study design was a cross-sectional, register-based study. The study sample included 1111 adults with first stroke (mild or moderate severity) admitted to three Swedish stroke units. The main outcome was cognition. The associations of pre-stroke physical activity, age, sex, smoking, diabetes, atrial fibrillation, previous TIA, statin treatment, hypertension treatment, reperfusion therapies, stroke severity, and education on the outcome cognition were analyzed using binary logistic regression. Physical activity was assessed within 48 h of admittance, and cognition was screened during stroke unit care. The results were: mean age 70 years, 40% women, 61% pre-stroke physically active, and 53% with post-stroke cognitive impairment. Patients with pre-stroke light or moderate physical activity have higher odds for intact cognition compared to inactive: odds ratio (95% confidence interval) 1.32 (0.97-1.80) and 2.04 (1.18-3.53), respectively. In addition to pre-stroke physical activity, people with younger age, a higher level of education, less severe stroke (more mild than moderate), being non-diabetic, and non-smoking have higher odds for intact cognition. In conclusion physical activity before stroke is associated with intact cognition in patients with mild and moderate stroke.
Association mapping of autumn-seeded rye (Secale cereale L.) reveals genetic linkages between genes controlling winter hardiness and plant development
Authors: Båga Monica , Bahrani Hirbod , Larsen Jamie , Hackauf Bernd , Graf Robert J. , Laroche Andre , Chibbar Ravindra N. 
Published: April 2022

AbstractWinter field survival (WFS) in autumn-seeded winter cereals is a complex trait associated with low temperature tolerance (LTT), prostrate growth habit (PGH), and final leaf number (FLN). WFS and the three sub-traits were analyzed by a genome-wide association study of 96 rye (Secale cerealL.) genotypes of different origins and winter-hardiness levels. A total of 10,244 single nucleotide polymorphism (SNP) markers were identified by genotyping by sequencing and 259 marker-trait-associations (MTAs;p < 0.01) were revealed by association mapping. The ten most significant SNPs (p < 1.49e−04) associated with WFS corresponded to nine strong candidate genes:Inducer of CBF Expression 1(ICE1),Cold-regulated 413-Plasma Membrane Protein 1(COR413-PM1),Ice Recrystallization Inhibition Protein 1(IRIP1),Jasmonate-resistant 1(JAR1),BIPP2C1-like protein phosphatase,Chloroplast Unusual Positioning Protein-1(CHUP1),FRIGIDA-like 4 (FRL4-like) protein,Chalcone Synthase 2(CHS2), andPhenylalanine Ammonia-lyase 8(PAL8). Seven of the candidate genes were also significant for one or several of the sub-traits supporting the hypothesis that WFS, LTT, FLN, and PGH are genetically interlinked. The winter-hardy rye genotypes generally carried additional allele variants for the strong candidate genes, which suggested allele diversity was a major contributor to cold acclimation efficiency and consistent high WFS under varying field conditions.
Imatinib inhibits SARS-CoV-2 infection by an off-target-mechanism
Authors: Strobelt Romano , Adler Julia , Paran Nir , Yahalom-Ronen Yfat , Melamed Sharon , Politi Boaz , Shulman Ziv , Schmiedel Dominik , Shaul Yosef 
Published: April 2022

AbstractThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal agent of the COVID-19 pandemic. More than 274 million individuals have suffered from COVID-19 and over five million people have died from this disease so far. Therefore, there is an urgent need for therapeutic drugs. Repurposing FDA approved drugs should be favored since evaluation of safety and efficacy of de-novo drug design are both costly and time consuming. We report that imatinib, an Abl tyrosine kinase inhibitor, robustly decreases SARS-CoV-2 infection and uncover a mechanism of action. We show that imatinib inhibits the infection of SARS-CoV-2 and its surrogate lentivector pseudotype. In latter, imatinib inhibited both routes of viral entry, endocytosis and membrane-fusion. We utilized a system to quantify in real-time cell–cell membrane fusion mediated by the SARS-CoV-2 surface protein, Spike, and its receptor, hACE2, to demonstrate that imatinib inhibits this process in an Abl1 and Abl2 independent manner. Furthermore, cellular thermal shift assay revealed a direct imatinib-Spike interaction that affects Spike susceptibility to trypsin digest. Collectively, our data suggest that imatinib inhibits Spike mediated viral entry by an off-target mechanism. These findings mark imatinib as a promising therapeutic drug in inhibiting the early steps of SARS-CoV-2 infection.
Improving the computational accuracy of the dynamic electro-geometrical model using numerical solutions
Authors: Adekitan Aderibigbe Israel 
Published: April 2022

AbstractThe dynamic electro-geometrical model has been applied in various studies to investigate the probability of a lightning strike to parts of a structure. The numerical computation of the dynamic electro-geometrical model (DEGM) follows an iterative step by determining lightning strike points from above to a point on a structure of interest. This computation is often time-consuming and requires extensive computational resources. This study delves into the inner workings of DEGM striking distance computation. It highlights sources of computational numerical errors, such as the effect of the discretisation size. It proposes ways to eliminate such by using a conversion factor while also significantly reducing computation time from more than 14 h to approximately 6 min for a cuboid structure by eliminating ground surface points. The performance of the proposed improved DEGM (IDEGM) was investigated using a floating roof tank and a cuboid structure with a central air termination, and an interception efficiency of 61% was achieved. An alternative case using catenary wires with a total lightning interception efficiency of 99.1% was also implemented. The percentage strike probability for the cases considered shows a close approximation to published results, and this confirms the accuracy of the implemented model. The IDEGM has the benefit of generating results with a significantly reduced computation time of just a few minutes as compared to several hours in previous models.
Acute-phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level
Authors: Wu Jin-Lin , Su Tung-Hung , Chen Pei-Jer , Chen Yun-Ru 
Published: April 2022

AbstractRegular hepatocellular carcinoma (HCC) surveillance by ultrasonography in combination with the α-fetoprotein (AFP) examination is unsatisfactory in diagnostic sensitivity for early-stage HCC especially in cirrhotic patients. We conducted a prospective study in a tertiary medical center in Taiwan and consecutively collected serum samples from patients with chronic hepatitis, liver cirrhosis (LC), or HCC for new biomarker discovery. Overall, 166 patients were enrolled, including 40 hepatitis, 30 LC, and 96 HCC. Four acute-phase serum amyloid A (A-SAA) derived biomarkers including total A-SAA, A-SAA monomer and oligomer, and protein misfolding cyclic amplification (PMCA) signal were measured and compared between patients with and without HCC. A-SAA biomarkers significantly increased in the HCC group when compared to the hepatitis and LC groups, and generally increased in more advanced tumor stages. Among A-SAA biomarkers, the area under the receiver operator characteristic curves (AUROCs) for PMCA signal in discrimination of all-stage and early-stage HCC were 0.86 and 0.9 in cirrhotic patients, which is comparable to AFP. For cirrhotic patients with low AFP (< 7 ng/mL), PMCA signal maintained good capacity in prediction of early-stage HCC (AUROC: 0.94). Serum A-SAA and its prion-like property showed a potential to complement AFP in detection of early-stage HCC.
Glucose and unstructured physical activity coupling during sleep and wake in young adults with type 1 diabetes
Authors: Griggs Stephanie , Barbato Eric , Hernandez Estefania , Gupta Devansh , Margevicius Seunghee , Grey Margaret , Hickman Ronald L. 
Published: April 2022

AbstractGlucose variations have a bidirectional relationship with the sleep/wake and circadian systems in type 1 diabetes (T1D); however, the mechanisms remain unclear. The aim of this study was to describe the coupling between glucose and unstructured physical activity over 168 h in young adults with T1D. We hypothesized that there would be differences in sleep and wake characteristics and circadian variations. Glucose was measured with a continuous glucose monitoring device every 5 min and activity with a non-dominant wrist-worn actigraph in 30-s epochs over 6–14 days. There was substantial glucose and unstructured physical activity coupling during sleep and wake, along with circadian variation based on the wavelet coherence analysis. The extent to which glucose fluctuations result in disrupted sleep over longer than one week should be examined considering the harmful effects on achieving glycemic targets. Further studies are needed to delineate the respective roles of glucose production and utilization and the potential for improved meal and insulin timing to optimize glucose and sleep in this population reliant on exogenous insulin.
Indole decreases the virulence of the bivalve model pathogens Vibrio tasmaniensis LGP32 and Vibrio crassostreae J2-9
Authors: Zhang Shanshan , Yang Qian , Fu Songzhe , Janssen Colin R. , Eggermont Mieke , Defoirdt Tom 
Published: April 2022

AbstractIndole signaling plays an important role in bacterial pathogenesis. In this study, the impact of indole on biofilm formation, swimming and swarming motility were explored in Vibrio tasmaniensis LGP32 and Vibrio crassostreae J2-9, two model pathogens of bivalves. The results showed that indole decreased swimming and swarming motility in both strains, and decreased biofilm formation in V. crassostreae J2-9. Furthermore, indole affected a large number of genes at RNA level, including genes related to metabolism, ABC transporters, flagellar assembly, chemotaxis, and response regulators. Finally, the bacterial virulence towards mussel larvae was decreased by pretreatment with indole in both V. tasmaniensis LGP32 and V. crassostreae J2-9. After 5 days, the survival rate of mussel larvae increased 2.4-fold and 2.8-fold in mussel larvae challenged with V. tasmaniensis LGP32 pretreated with 200 µM and 500 µM indole, respectively. The survival rate of mussel larvae increased 1.5-fold and 1.9-fold in mussel larvae challenged with V. crassostreae J2-9 pretreated with 200 µM and 500 µM indole, respectively. These data indicate that indole has a significant impact on the virulence of V. tasmaniensis LGP32 and V. crassostreae J2-9, and indole signaling could be a promising target for antivirulence therapy.
Differentiating solitary brain metastases from glioblastoma by radiomics features derived from MRI and 18F-FDG-PET and the combined application of multiple models
Authors: Cao Xu , Tan Duo , Liu Zhi , Liao Meng , Kan Yubo , Yao Rui , Zhang Liqiang , Nie Lisha , Liao Ruikun , Chen Shanxiong , Xie Mingguo 
Published: April 2022

AbstractThis study aimed to explore the ability of radiomics derived from both MRI and 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) images to differentiate glioblastoma (GBM) from solitary brain metastases (SBM) and to investigate the combined application of multiple models. The imaging data of 100 patients with brain tumours (50 GBMs and 50 SBMs) were retrospectively analysed. Three model sets were built on MRI, 18F-FDG-PET, and MRI combined with 18F-FDG-PET using five feature selection methods and five classification algorithms. The model set with the highest average AUC value was selected, in which some models were selected and divided into Groups A, B, and C. Individual and joint voting predictions were performed in each group for the entire data. The model set based on MRI combined with 18F-FDG-PET had the highest average AUC compared with isolated MRI or 18F-FDG-PET. Joint voting prediction showed better performance than the individual prediction when all models reached an agreement. In conclusion, radiomics derived from MRI and 18F-FDG-PET could help differentiate GBM from SBM preoperatively. The combined application of multiple models can provide greater benefits.
Resident birds are more behaviourally plastic than migrants
Authors: Morelli Federico , Benedetti Yanina , Blumstein Daniel T. 
Published: April 2022

AbstractSpecies subjected to more variable environments should have greater phenotypic plasticity than those that are more restricted to specific habitat types leading to the expectation that migratory birds should be relatively more plastic than resident birds. We tested this comparatively by studying variation in flight initiation distance (FID), a well-studied antipredator behaviour. We predicted that variation in FID would be greater for migratory species because they encountered a variety of locations during their lives and therefore had less predictable assessments of risk compared to more sedentary species. Contrary to our prediction, we found that non-migratory species (sedentary) had greater variation in FID than migratory ones. Migratory and partially migratory birds had greater average FIDs than sedentary birds, suggesting that they were generally more wary. These results suggest that the predictability associated with not migrating permits more nuanced risk assessment which was seen in the greater variation in FID of sedentary bird species.