bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are there functional biomechanical differences in robotic arm-assisted bi-unicompartmental knee arthroplasty compared with conventional total knee arthroplasty? A prospective, randomized controlled trial
Authors: Banger Matthew S. , Doonan James , Jones Bryn G. , MacLean Angus D. , Rowe Philip J. , Blyth Mark J. G. 
Published: April 2022

Aims The aim of this study was to compare any differences in the primary outcome (biphasic flexion knee moment during gait) of robotic arm-assisted bi-unicompartmental knee arthroplasty (bi-UKA) with conventional mechanically aligned total knee arthroplasty (TKA) at one year post-surgery. Methods A total of 76 patients (34 bi-UKA and 42 TKA patients) were analyzed in a prospective, single-centre, randomized controlled trial. Flat ground shod gait analysis was performed preoperatively and one year postoperatively. Knee flexion moment was calculated from motion capture markers and force plates. The same setup determined proprioception outcomes during a joint position sense test and one-leg standing. Surgery allocation, surgeon, and secondary outcomes were analyzed for prediction of the primary outcome from a binary regression model. Results Both interventions were shown to be effective treatment options, with no significant differences shown between interventions for the primary outcome of this study (18/35 (51.4%) biphasic TKA patients vs 20/31 (64.5%) biphasic bi-UKA patients; p = 0.558). All outcomes were compared to an age-matched, healthy cohort that outperformed both groups, indicating residual deficits exists following surgery. Logistic regression analysis of primary outcome with secondary outcomes indicated that the most significant predictor of postoperative biphasic knee moments was preoperative knee moment profile and trochlear degradation (Outerbridge) (R2 = 0.381; p = 0.002, p = 0.046). A separate regression of alignment against primary outcome indicated significant bi-UKA femoral and tibial axial alignment (R2 = 0.352; p = 0.029), and TKA femoral sagittal alignment (R2 = 0.252; p = 0.016). The bi-UKA group showed a significant increased ability in the proprioceptive joint position test, but no difference was found in more dynamic testing of proprioception. Conclusion Robotic arm-assisted bi-UKA demonstrated equivalence to TKA in achieving a biphasic gait pattern after surgery for osteoarthritis of the knee. Both treatments are successful at improving gait, but both leave the patients with a functional limitation that is not present in healthy age-matched controls. Cite this article: Bone Joint J 2022;103-B(4):433–443.
Debridement, antibiotics, and implant retention after revision arthroplasty
Authors: Veerman Karin , Raessens Joris , Telgt Denise , Smulders Katrijn , Goosen Jon H. M. 
Published: April 2022

Aims Debridement, antibiotics, and implant retention (DAIR) is a widely accepted form of surgical treatment for patients with an early periprosthetic joint infection (PJI) after primary arthroplasty. The outcome of DAIR after revision arthroplasty, however, has not been reported. The aim of this study was to report the success rate of DAIR after revision arthroplasty with a follow-up of two years. Methods This retrospective study, conducted at the Sint Maartenskliniek, Nijmegen, the Netherlands, included 88 patients who underwent DAIR within 90 days of revision total hip or total knee arthroplasty between 2012 and 2019. Details of the surgical procedures and PJI were collected. Univariate analysis and a subgroup analysis of the culture-positive group were performed. Kaplan-Meier survivorship curves were constructed. Results The overall success rate of DAIR, with respect to the retention of components and the cure of infection, was 68% after two years. DAIR performed with an interval of > 30 days after the index revision procedure (odds ratio (OR) 0.24 (95% confidence interval (CI) 0.08 to 0.72); p = 0.008), a repeated DAIR within 90 days (OR 0.37 (95% CI 0.14 to 0.97); p = 0.040), and the use of an immunosuppressive agent (OR 0.13 (95% CI 0.02 to 0.67); p = 0.012) were associated with a significantly reduced success rate. In the culture-positive group, a mismatch between the antibiotic treatment and the susceptibility of the organism was associated with a significantly lower success rate (OR 0.13 (95% CI 0.03 to 0.62); p = 0.007). Conclusion DAIR is an acceptable form of surgical treatment for patients with a suspected early PJI after revision arthroplasty of the hip or knee. DAIRs performed after a prolonged interval, multiple DAIRs, and antibiotic mismatches were significantly associated with an increased risk of failure. Optimization of the host immune response and the prevention of antibiotic mismatch are modifiable factors that may improve the outcome. The high rate of mismatches was an important finding, underlining the need for a review of the local microbiological data, which might improve the outcome. Cite this article: Bone Joint J 2022;104-B(4):464–471.
Curve type, flexibility, correction, and rotation are predictors of curve progression in patients with adolescent idiopathic scoliosis undergoing conservative treatment
Authors: Wong Lester P. K. , Cheung Prudence W. H. , Cheung Jason P. Y. 
Published: April 2022

Aims The aim of this study was to review the current evidence surrounding curve type and morphology on curve progression risk in adolescent idiopathic scoliosis (AIS). Methods A comprehensive search was conducted by two independent reviewers on PubMed, Embase, Medline, and Web of Science to obtain all published information on morphological predictors of AIS progression. Search items included ‘adolescent idiopathic scoliosis’, ‘progression’, and ‘imaging’. The inclusion and exclusion criteria were carefully defined. Risk of bias of studies was assessed with the Quality in Prognostic Studies tool, and level of evidence for each predictor was rated with the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. In all, 6,286 publications were identified with 3,598 being subjected to secondary scrutiny. Ultimately, 26 publications (25 datasets) were included in this review. Results For unbraced patients, high and moderate evidence was found for Cobb angle and curve type as predictors, respectively. Initial Cobb angle > 25° and thoracic curves were predictive of curve progression. For braced patients, flexibility < 28% and limited in-brace correction were factors predictive of progression with high and moderate evidence, respectively. Thoracic curves, high apical vertebral rotation, large rib vertebra angle difference, small rib vertebra angle on the convex side, and low pelvic tilt had weak evidence as predictors of curve progression. Conclusion For curve progression, strong and consistent evidence is found for Cobb angle, curve type, flexibility, and correction rate. Cobb angle > 25° and flexibility < 28% are found to be important thresholds to guide clinical prognostication. Despite the low evidence, apical vertebral rotation, rib morphology, and pelvic tilt may be promising factors. Cite this article: Bone Joint J 2022;104-B(4):424–432.
The role of CDH2 and MCP-1 mRNAs of blood extracellular vesicles in predicting early-stage diabetic nephropathy
Authors: Dehghanbanadaki Hojat , Forouzanfar Katayoon , Kakaei Ardeshir , Zeidi Samaneh , Salehi Negar , Arjmand Babak , Razi Farideh , Hashemi Ehsan 
Published: April 2022

Background
Extracellular vesicles (EVs), including exosomes and microvesicles, are involved in intercellular communication by transferring biomolecules such as mRNA, which has been shown to be as essential biomarkers for many physiological and pathological conditions such as diabetic nephropathy (DN). This study aimed to investigate the expression of CDH1, CDH2, MCP-1, and PAI-1 mRNAs in blood EVs of DN patients and to determine their accuracy in predicting early-stage DN.

Methods
We recruited 196 participants, including 35 overt DN patients, 53 incipient DN patients, 62 diabetic patients (DM), and 46 healthy individuals. Quantification of the mRNA profile of blood EVs was performed using the qRT-PCR method. The diagnostic performance of mRNA was evaluated using receiver operating characteristic analysis.

Results
The mRNA expression of CDH2 and MCP-1 was downregulated in overt DN group (0.22-fold change and 0.15-fold change, respectively) and incipient DN group (0.60-fold change and 0.43-fold change, respectively) compared to DM group (1.72-fold change and 2.77-fold change, respectively), while PAI-1 mRNA expression decreased in incipient DN group (0.70-fold change) and DM group (0.58-fold change) compared to control. However, the expression level of CDH1 mRNA was not significantly different among the four groups (p = 0.408). Moreover, CDH2 and MCP-1 mRNAs inversely correlated with creatinine (r = -0.370 and r = -0.361, p<0.001) and Alb/Cr ratio (r = -0.355 and r = -0.297, p<0.001). 1/CDH2 mRNA also predicted overt DN with an accuracy of 0.75 (95%CI: 0.65–0.85) and incipient DN with an accuracy of 0.61 (95%CI: 0.50–0.71) while 1/MCP-1 mRNA had an accuracy of 0.66 (95%CI: 0.55–0.77) for overt DN prediction and an accuracy of 0.61 (95%CI: 0.51–0.71) for incipient DN prediction.

Conclusion
CDH2 and MCP-1 mRNAs expression in blood EVs was decreased with the development of DN, suggesting the renoprotective effect of these mRNAs in diabetic individuals. Moreover, their quantifications could serve as diagnostic biomarkers for early-stage DN.
Sickness absence and disability pension trajectories in childhood cancer survivors and references- a Swedish prospective cohort study
Authors: Baecklund Fredrik , Alexanderson Kristina A. E. , Mittendorfer-Rutz Ellenor , Chen Lingjing 
Published: April 2022

Background
Childhood cancer survivors are at high risk of chronic health conditions. We aimed to explore future long-term sickness absence and disability pension in young adult childhood cancer survivors and matched references.

Methods
We performed a prospective cohort study using microdata from five Swedish nationwide registers. Among all individuals born 1976–1998 and living in Sweden, we included 3632 childhood cancer survivors and 17,468 matched references that could be followed-up for 15, 10, or 5 years, respectively. A group-based trajectory model was applied to identify trajectories of mean annual sickness absence and/or disability pension days (SADP) in each sub-cohort, with 95% confidence intervals (CI). Potential risk factors for trajectory belonging were explored using χ2 test and multinomial logistic regression.

Results
Most young adult childhood cancer survivors (90.2–96.5%) and references (97.4–98.8%) followed a No SADP trajectory. A larger proportion of childhood cancer survivors than references followed a Moderate (33–102 days/year) or High (115–260 days/year) SADP trajectory (15-year follow-up cohorts: Moderate 4.6% versus 1.2%; High 5.1% versus 1.5%). Childhood cancer survivors of central nervous system (CNS) tumors were at higher risk of the High SADP trajectory than childhood cancer survivors of hematological or non-CNS solid tumors (hematological versus CNS: odds ratio = 2.30, 95% CI 1.23–4.30; hematological versus non-CNS: odds ratio = 0.32, 95% CI 0.13–0.79).

Conclusions
Although most young adult childhood cancer survivors had no SADP during follow-up, 9.7% experienced moderate or high numbers of SADP days/year throughout the 15-year follow-up; compared to 2.7% among references. CNS tumor survivors were at particular risk of SADP long-term and need extra attention in their future work prospect.
Relationship between dynamic changes of peri-procedure anxiety and short-term prognosis in patients undergoing elective percutaneous coronary intervention for coronary heart disease: A single-center, prospective study
Authors: Hu Yao-yao , Cai Ya-jing , Jiang Xin , Mao Fang-ying , Zhang Jing , Liu Lin , Wu Qing , Wang Xiao-hua 
Published: April 2022

Background
Patients with coronary heart disease (CHD) often experience anxiety, but the current studies on anxiety mostly focused on a certain point in time. Therefore, this study aimed to investigate the dynamic changes of peri-procedure anxiety, status of post-procedure quality of life, and cardiovascular readmission rates in patients with CHD who undergoing elective percutaneous coronary intervention (PCI), and to analyze the influence of peri-procedure anxiety on quality of life and readmission rate after PCI.

Methods
This prospective study was conducted at Changshu NO.1 People’s Hospital. A total of 220 patients with CHD undergoing elective PCI were selected as study subjects. The general information, clinical data, anxiety, quality of life and readmission of patients were collected. Multivariate linear regression was used to examine the effect of peri-procedure anxiety on quality of life, and multivariate logistic regression was used to analyze the influence of peri-procedure anxiety on readmission rate.

Results
This study showed the anxiety scores at hospitalization appointment(T1), 3 days before procedure(T2), 1 day before procedure(T3), 1 day after procedure(T4) were 57(55,61),64(61,68),54(51.58), and 54(50,60), respectively. And, at 3 months and 6 months after PCI, the scores of Seattle Angina Questionnaire (SAQ) were 346.61(319.06,366.52) and 353.34(334.18,372.84) respectively. During 6 months follow-up, 54 cases were readmitted, with a readmission rate of 25.5%. Statistical analysis showed that T1 with anxiety (P = 0.002) and T2 with anxiety (P = 0.024) were independent risk factors for treatment satisfaction at 3 months after PCI. Anxiety in T4 (P = 0.005) was an independent risk factor on the angina frequency at 6 months after PCI. T2 with anxiety (B = 1.445, P = 0.010, 95%CI:1.409–12.773) and T4 without anxiety (B = -1.587, P = 0.042, 95%CI:-0.044–0.941) were risk factors affecting readmission for cardiovascular reasons within 6 months.

Conclusion
Patient anxiety at T1 and T2 affects the treatment satisfaction dimension of the SAQ at 3 months after PCI, and anxiety at T4 affects the angina frequency dimension of the SAQ at 6 months after PCI. Anxiety at T2 and no anxiety at T4 increase short-term readmission rates. In the future, interventions should be strengthened at various time points in the peri-procedure period to improve post-procedure rehabilitation effect.
Influence of riverine connectivity on phytoplankton abundance and diversity of associated wetlands of River Ganga: A comparative study of an open and a closed wetland
Authors: Bayen Supriti , Mohanty Trupti Rani , Chanu Thangjam Nirupada , Johnson Canciyal , Tiwari Nitish Kumar , Manna Ranjan Kumar , Swain Himanshu Sekhar , Das Basanta Kumar 
Published: April 2022

AbstractRiver connectivity is often described as a key requirement for maintaining the health and biodiversity of associated wetlands of rivers. A comparative study was undertaken to understand the influence of river connectivity on plankton diversity and abundance in an open (Chharaganga Beel) and a closed wetland (Kalobaur Beel) situated on the banks of River Ganga in West Bengal, India. During the present investigation, data revealed that the major groups of phytoplankton recorded were Cyanobacteria (33.12%), Bacillariophyta (29.07%), and Chlorophyta (22.34%) from the open wetland, and Bacillariophyta (47.40%), Euglenozoa (30.68%), and Chlorophyta (10.12%) from the closed one. Shannon diversity (H’) and Margalef's species richness index indicate that phytoplankton diversity in the Chharaganga ecosystem was higher than in Kalobaur Beel. A one-way ANOVA showed significant station-wise difference for water turbidity (p &lt;0.05) in both of the beels, and student t test revealed that differences in physico-chemical parameters between the studied beels was statistically significant (p &lt;0.05) for depth, turbidity, conductivity, total hardness, nitrate, total N, phosphate-P, silicate, Ca²+, Mg²+and chlorophyll a,whereas abundance of phytoplankton groups was significantly different for Bacillariophyta (p &lt;0.05) and Euglenozoa (p &lt;0.05). The positive correlation of total N with Euglenozoa (r=0.496; p&lt;0.05) might be the cause of favourable conditions for a higher abundance of Euglenozoa in the closed Kalobaur Beel,which is on the verge of partial eutrophication. The hydrological flushing by river water in the Chharaganga wetland maintains the ecological stability. Therefore, restoration of river connectivity is recommended to improve the health of the disconnected wetlands.
Resilience of inland fishers against nature's fury: A study on effect of extremely severe cyclone Fani on socio-economy and livelihood of fisher households in Odisha, India
Authors: Pandit Arun , Saha Avishek , Chakraborty Lokenath , Swain H.S. , Sharma Shravan K. , Mohanty B.P. , Das B.K. 
Published: April 2022

Abstract
The extremely severe cyclonic storm, Fani, the strongest tropical cyclone to hit India in 20 years, caused a landfall in the Bay of Bengal coast of Odisha, India in May 2019 and considerably impacted the lives and livelihoods of fisher families. The present study was based on primary data collected from 150 fishers’ households located around Debi River, Mahanadi Estuary and Chilika Lagoon in Odisha. Twenty four per cent of the respondents reported severe damages to their kachha houses, while 43% respondent reported loss of fishing nets due to this extreme cyclonic event. Around 37% of the fishing boats were severely damaged. The household items and stored agricultural produce were also damaged. The damages were much less in Mahanadi Estuary and northern sector of Chilika Lagoon due to reduced intensity of the storm. The study further found that overall the resilience of the fisher households was poor. Six out of 12 indicators of resilience were in ‘crisis’ category while only four were in ‘desirable’ category. The Government needs to consider providing quick assistance to the fishers keeping in view the loss of livelihood; besides, special initiatives are necessary to be planned to enhance the resilience of the fisher households for such unforeseen events which have become regular occurrences in the east coast of Bay of Bengal.
An overview of enclosure culture in inland open waters of India: Responding to socio-economic, ecological, and climate change issues in inland fisheries
Authors: Debnath D. , Bhattacharjya B.K. , Yengkokpam S. , Sarkar U.K. , Hassan M.A. , Das A.K. , Das B.K. 
Published: April 2022

Abstract
Inland open-access fisheries of India are important resources that contribute significantly to the national economy while providing livelihood to millions. The majority of these resources are suitable for aquaculture, with a high potential for enhanced inland fish production. Enclosures (cages and pens) installed in such waters are useful for rearing fingerlings for enhancement programmes and table-fish production. Floating cages are most suitable for waterbodies vulnerable to occasional flooding, while pen enclosures installed in marginal areas of floodplain wetlands can be suitably reinforced to protect the fish during floods. Small indigenous fishes can be introduced into pens to increase their productivity. This paper reviews enclosure technologies in the inland open waters of India and discusses the socio-economic benefits, ecological advantages, and climate resilience of these technologies. These factors may encourage their adoption and lead to an increase in fish production in the large inland waters of India.
The effect of supply chain learning on flexibility performance: an empirical study
Authors: Meidute-Kavaliauskiene Ieva , ÇİĞDEM Şemsettin , YILDIZ Bülent 
Published: April 2022

Today’s intensely competitive business is undergoing significant shifts, which render it a challenging environment to compete in. Production processes are evolving as customer demands change, which leads to greater variability. Firms must respond to changing environmental conditions to remain sustainable. Companies today look for ways to overcome their problems not only on their own but also with their supply chains. Reduced cost and improved performance are two significant benefits of supply chain management. Because companies can work together in the face of challenging market conditions throughout their supply chains, it makes sense for them to collaborate. When companies work together, they can collaborate to produce better-designed products and more efficient manufacturing processes. Learning, supply chain integration, and flexibility throughout the supply chain are critical to successful supply chain management.
In this study, the effect of supply chain learning on supply chain integration and production flexibility has been investigated. The mediating role of supply chain integration on the impact of supply-chain learning on production flexibility has been tested. For this purpose, survey data was collected from the 144 companies selected out of Turkey's largest exporting companies. The data were analyzed via structural equation modeling and process macro methods. As a result of the structural equation model analysis, it was found that supply chain learning significantly affects the chain’s integration and its production flexibility. As a result of the intermediation test, it was determined that the integration of the supply chain has a vital intermediary role regarding the effect of supply chain learning on the flexibility of production.
Multifunctional nanoparticles for targeted delivery of apoptin plasmid in cancer treatment
Authors: He Zhuanxia , Bao Ke , Zhang Jiawei , Ju Dandan , Luo Mingyan , Liu Liyan , Gao Xiujun 
Published: April 2022

Abstract
The systemic toxicity and low efficacy of traditional chemotherapy for hepatocellular carcinoma (HCC) result in poor clinical outcomes. This study was designed to achieve targeted delivery of apoptin plasmid (AP) to liver tumors and killing of cancer cells using multifunctional nanoparticles (MFNPs) having sustained-release properties. The MFNPs featuring a distinct core-shell structure were prepared using poly(lactic-glycolic acid)-ε-polylysine copolymer and loaded with AP by adsorption. Specific targeting of liver tumor cells was achieved by biotinylation of the nanoparticles (NPs), while an improvement in lysosomal escape and nuclear localization enhanced the tumor cell killing capability of AP. Blank MFNPs exhibited good biocompatibility while AP-loaded NPs were found to exert strong inhibitory effects on both tumor cells in vitro and solid tumors in vivo. Taken together, these findings demonstrate a promising route for the development of tumor-targeted NPs which may lead to improved therapeutic strategies for treating HCC.
Development of a risk-stratification scoring system for predicting risk of breast cancer based on non-alcoholic fatty liver disease, non-alcoholic fatty pancreas disease, and uric acid
Authors: Hong Chuntian , Yan Yonghao , Su Liyang , Chen Debo , Zhang Changqing 
Published: April 2022

Abstract
Many breast cancer patients have both non-alcoholic fatty liver disease (NAFLD) and non-alcoholic fatty pancreas disease (NAFPD). Consequently, we hypothesized that NAFPD and NAFLD were associated with breast cancer, and aimed to build a novel risk-stratification scoring system based on it. In this study, a total of 961 patients with breast cancer and 1,006 non-cancer patients were recruited. The clinical characteristics were collected and analyzed using logistic analysis. Risk factors were assessed by a risk rating system. Univariate analysis showed that body mass index, triglyceride, total cholesterol, NAFLD, NAFPD, low-density lipoprotein, and uric acid (UA) were significantly related to breast cancer. Among them, NAFLD, NAFPD, and UA were independent risk factors related to breast cancer identified by multivariate analysis. The risk assessment model was established based on these factors and demonstrated that the odds ratio sharply increased with the rising scores. Compared with the low-risk group, the odds ratio in the intermediate- and high-risk groups were 1.662 (1.380–2.001) and 3.185 (2.145–4.728), respectively. In conclusion, the risk-stratification scoring system combining NAFLD, NAFPD, and UA can accurately predict the occurrence of breast cancer.