bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of age on the hippocampus and verbal memory in adults with autism spectrum disorder: Longitudinal versus cross‐sectional findings
Authors: Pagni Broc A. , Walsh Melissa J. M. , Ofori Edward , Chen Kewei , Sullivan Georgia , Alvar Jocelyn , Monahan Leanna , Guerithault Nicolas , Delaney Shanna , Braden B. Blair 
Published: August 2022

AbstractResearch studying aging in adults with autism spectrum disorder (ASD) is growing, but longitudinal work is needed. Autistic adults have increased risk of dementia, altered hippocampal volumes and fornix integrity, and verbal memory difficulties compared with neurotypical (NT) adults. This study examined longitudinal aging in middle‐age adults with ASD versus a matched NT group, and compared findings with cross‐sectional age effects across a broad adult age range. Participants were 194 adults with (n = 106; 74 male) and without (n = 88; 52 male) ASD, ages 18–71. Participants (n = 45; 40–70 age range) with two visits (2–3 years apart) were included in a longitudinal analysis. Hippocampal volume, fornix fractional anisotropy (FA), and verbal memory were measured via T1‐weighted MRI, diffusion tensor imaging, and the Rey Auditory Verbal Learning Test, respectively. Longitudinal mixed models were used for hippocampal system variables and reliable change index categories were used for Auditory Verbal Learning Test analyses. Multivariate regression was used for cross‐sectional analyses. Middle‐age adults with ASD had greater longitudinal hippocampal volume loss and were more likely to show clinically meaningful decline in short‐term memory, compared with NT. In contrast, cross‐sectional associations between increasing age and worsening short‐term memory were identified in NT, but not autistic adults. Reduced fornix FA and long‐term memory in ASD were found across the broad cross‐sectional age range. These preliminary longitudinal findings suggest accelerated hippocampal volume loss in ASD and slightly higher rates of clinically‐meaningful decline in verbal short‐term memory. Contradictory cross‐sectional and longitudinal results underscore the importance of longitudinal aging research in autistic adults.Lay SummaryAutistic adults have increased risk of dementia, differences in brain memory structures, and difficulty with memory compared with neurotypical (NT) adults. However, there are no publications that follow the same middle‐age autistic adults over time to see how their brain and memory change. Our preliminary findings in a small middle‐age autism sample suggest a key memory brain structure, the hippocampus, may shrink faster over 2–3 years compared with NT, and short‐term memory may become more challenging for some. Across a broad adult range, autistic adults also had reduced integrity of connections to the hippocampus and greater challenges with long‐term memory. In our larger sample across a broad age range, the results did not hint at this aforementioned pattern of accelerated aging. This underscores the importance of more aging research in autism, and especially research where people are followed over time.
Changes in uridine 5′‐diphospho‐glucuronosyltransferase 1A6 expression by histone deacetylase inhibitor valproic acid
Authors: Sakakibara Yukiko , Kojima Ayaka , Asai Yuki , Nadai Masayuki , Katoh Miki 
Published: August 2022

AbstractValproic acid (VPA) is well‐known as a histone deacetylase (HDAC) inhibitor. It has been reported that HDAC inhibitors enhance basal and aryl hydrocarbon receptor (AhR) ligand‐induced aryl hydrocarbon receptor‐responsive gene expression. Other studies suggested that HDAC inhibition might significantly activate the NF‐E2‐related factor‐2 (Nrf2). Moreover, VPA activates mitogen‐activated protein kinases (MAPKs). MAPK pathways regulate Nrf2 transactivation domain activity. Uridine 5′‐diphospho‐glucuronosyltransferase (UGT) 1A6 is one of the important isoforms to affect drug pharmacokinetics. UGT1A6 gene is regulated transcriptionally by AhR and Nrf2. The present study aimed to investigate whether UGT1A6 expression was changed by VPA and to elucidate the mechanism of the alteration. Following VPA treatment for 72 h in Caco‐2 cells, UGT1A6 mRNA was increased by 7.9‐fold. Moreover, UGT1A6 mRNA was increased by other HDAC inhibitors, suggesting that HDAC inhibition caused the UGT1A6 mRNA induction. AhR and Nrf2 proteins in the nucleus of Caco‐2 cells were increased by 1.5‐ and 1.7‐fold, respectively, following the VPA treatment. However, VPA treatment did not activate the extracellular signal‐regulated kinase (ERK) and c‐Jun N‐terminal kinase (JNK) pathways in Caco‐2 cells. In conclusion, we observed that VPA induced UGT1A6 mRNA expression via AhR and Nrf2 pathways, but not via the ERK or JNK pathways.
Fabrication of polyaniline/graphene oxide composites for implementation in humidity sensing
Authors: Srivastava Divyanshi , Shukla Rajesh Kumar , Mishra Sheo K. , Gangwar Chinky , Kumar Indresh , Naik Radhey Mohan , Singh Santosh Kumar 
Published: August 2022

AbstractThis work reports the measurement of impedance variations under various humidity conditions at frequency ranges between 100 Hz and 5 MHz. An electrochemical polymerization process has been used in the synthesis including varying the mass ratios of graphene oxide (GO) in polyaniline. An electrochemical deposition method has been used to produce a sample film on an indium tin oxide glass slide. The percentage relative humidity (RH%) of the samples has been estimated to be 20–90%. Impedance and humidity had an inverse relationship, i.e. the impedance value decreased with an increase in humidity. In contrast with platinum capacitive humidity sensors (HS), the GO‐based HS had a sensitivity of 75–99%, which was ~10‐fold more than that of traditional sensors. With three different parameter weight % of GO, the frequency range have been 100 Hz to 5 MHz and RH% has been found to 20–90%. The HS showed a fast response and recovery time. Therefore, GO appears to be a useful material for building HS with high sensitivity for a comprehensive approach.
Combustion‐assisted Ca8.25Na1.5Al6O18:Sm3+ phosphors for solid‐state lighting and WLED applications
Authors: Dhapodkar Toshi S. , Kadam Abhijeet R. , Dhoble Sanjay J. 
Published: August 2022

AbstractAluminate‐based phosphors have been the most investigated luminescent phosphors over decades due to their outstanding optical properties. In the proposed work, a series of Sm3+‐doped Ca8.25Na1.5Al6O18 (CNAO) phosphor sample was prepared using a simple combustion technique with the help of two fuels i.e., urea–glycine. The purity of phase and structural analysis of the CNAO phosphors were confirmed using X‐ray diffraction analysis. Vibrational features of this phosphors confirmed were via Fourier transform infrared analysis. A photoluminescence study of this phosphor showed a doublet emission at 568 and 576 nm in the yellow region attributable to the 4G5/2→6H5/2 transition of Sm3+ ions, whereas a doublet peak noticed in red region ranged from 600 to 620 nm and was attributable to the 4G5/2→6H7/2 transition of Sm3+ ions. Moreover, Commission Internationale de l'éclairage colour coordinates were also located in the yellowish‐red region and confirmed the potential of this phosphor as a yellowish‐red component for white light‐emitting diodes and display devices applications.
Non‐siliceous ordered mesoporous materials via nanocasting for small molecule conversion electrocatalysis
Authors: Baek Du San , Joo Sang Hoon 
Published: August 2022

AbstractSince the pioneering work of Ryoo and co‐workers in 1999 on the synthesis of ordered mesoporous carbons via nanocasting, the nanocasting pathway has endured the test of time and has established itself as a robust and versatile method for preparing ordered mesoporous materials (OMMs). This method enables the generation of a remarkably wide range of non‐siliceous OMMs, some of which are otherwise inaccessible. In this account, we present our decade‐long efforts toward the function‐oriented design of non‐siliceous OMM‐based electrocatalysts for promoting small molecule conversion reactions relevant to renewable energy conversion and commodity chemical production, including hydrogen evolution reaction, oxygen evolution reaction, and selective oxygen reduction reaction. We also discuss the extension of the nanocasting concept to a silica‐coating‐mediated synthesis for preparing new catalytic materials. We conclude the account by suggesting the remaining challenges and outlook for the future development of advanced OMMs.
Digitalization and sustainable development: How could digital economy development improve green innovation in China?
Authors: Luo Shiyue , Yimamu Nafisa , Li Yueran , Wu Haitao , Irfan Muhammad , Hao Yu 
Published: August 2022

AbstractIn the context of sustainable development, countries around the world shed more light on green innovation in their environmental policies, and the digital economy may take a vital part in improving green innovation. Predicted on the panel data of 278 cities in China from 2011 to 2019, this research administrates the principal component analysis (PCA) to evaluate the advancement level of the urban digital economy and employs the number of urban green patent applications to represent green innovation level. Through the benchmark regression model, the mediating effect model, the spatial Durbin model, the dynamic threshold panel model, and the gradual difference‐in‐difference model, this paper explores the direct effect, indirect effect, spatial effect, nonlinear relationship, and policy effect of that digital economy has on green innovation. The development of the digital economy can improve green innovation levels in indirect ways, such as by boosting the degree of economic openness, optimizing the industrial structure, and expanding the market potential, and as economic openness, industrial structure, and market potential advance, the promotion intensity of digital economy on green innovation is becoming lower and lower. The development of green innovation has an obvious spatial spillover effect. Still, the enhancement of green innovation in more developed regions may inhibit green innovation in less developed regions due to talent flow and industrial transfer. Finally, the gradual difference‐in‐difference model founded on the ‘Broadband China’ pilot policy supplementarily verifies that digital economy enhancement can substantially advance urban green innovation.
Real‐life second‐line epirubicin–paclitaxel regimen as treatment of relapsed small‐cell lung cancer: EpiTax study
Authors: Annic Josselin , Babey Hélène , Corre Romain , Descourt Renaud , Quéré Gilles , Renaud Emmanuelle , Lambert Mickaël , Le Noac'h Pierre , Dhamelincourt Estelle , Nguyen Jessica , Vu Alicia , Bourbonne Vincent , Robinet Gilles , Geier Margaux 
Published: August 2022

AbstractBackgroundFew therapeutic options are approved as second‐line treatment after failure of platinum‐based chemotherapy for patients with extensive‐stage small‐cell lung cancer (ES‐SCLC). Topotecan widespread use remains challenged by the risk of severe toxicities in a pretreated population. Little is known about the efficacy and safety of epirubicin–paclitaxel doublet in second‐line and beyond and especially cerebral outcomes.MethodsEpiTax is a retrospective multicenter observational real‐life study. We evaluated the efficacy of epirubicin 90 mg/m2 combined with paclitaxel 175 mg/m2 every 3 weeks in SCLC patients after failure of at least one line of platinum‐based chemotherapy. The primary endpoint was progression‐free survival (PFS). Secondary endpoints were overall survival (OS), objective response rate (ORR), disease control rate (DCR), intracranial control rate (ICR), and safety.ResultsA total of 29 patients were included. The median of previous systemic therapy lines was 2 (1–4). Eleven patients received the treatment in the second line. Characteristics of patients were a median age of 60 years (45–77), 65.5% of males with 72.4% of PS 0–1. Fifteen patients had a history of brain metastases. Median PFS and OS achieved 11.0 (95% CI, 8.1–16.3) and 23 (95% CI, 14.1–29.6) weeks, respectively. ORR was 34.5% and DCR was 55.2%. ICR was 3/15 (20%). Grade 3–4 adverse events were mainly hematological and concerned 7 patients. No case of febrile neutropenia or toxic death was reported.ConclusionEpirubicin–paclitaxel association highlighted promising efficacy with PFS and OS of 11 and 23 weeks, respectively, ORR of 34.5%, and a tolerable safety profile. This doublet could represent another valuable therapeutic option for ES‐SCLC patients treated in the second line and beyond.
Marine Based Natural Products: Exploring the Recent Developments in the Identification of Antimicrobial Agents
Authors: Krishna M. S. Ajay , Mohan Sangeetha , Ashitha K. T. , Chandramouli Manasa , Kumaran Alaganandam , Ningaiah Srikantamurthy , Babu K. Suresh , Somappa Sasidhar B. 
Published: August 2022

AbstractThe marine ecosystem is the less explored, biologically diverse, and vastest resource to discover novel antimicrobial agents. In recent decades’ antimicrobial drugs are losing their effectiveness due to the growing resistance among pathogens, which causes diseases to have considerable death rates across the globe. Therefore, there is a need for the discovery of new antibacterials that can reach the market. There is a gradual growth of compounds from marine sources which are entering the clinical trials. Thus, the prominence of marine natural products in the field of drug design and discovery across the academia and pharmaceutical industry is gaining attention. Herein, the present review covers nearly 200 marine based antimicrobial agents of 11 structural classes discovered from the year 2010 to 2022. All the discussed compounds have exhibited medium to high antimicrobial activity in inhibiting various microorganisms.
Inoperable poorly differentiated SCC to vertex of scalp progressing into sagittal sinus treated with palliative Cemiplimab
Authors: Grounds Katie , Emmanuel O 
Published: August 2022

AbstractCutaneous squamous cell carcinoma (cSCC) is the second most common non‐melanoma skin cancer after basal cell carcinoma, characterized by the malignant proliferation of epidermal keratinocytes. We report a case of an inoperable cSCC of the scalp extending into the sagittal sinus, now responding well to the monoclonal antibody Cemiplimab.
Re‐expansion pulmonary edema after chest tube drainage of malignant pleural effusion
Authors: Inada Sachiho , Sugimoto Hiroshi , Nakata Kyosuke 
Published: August 2022

AbstractA 62‐year‐old man presented with a 3‐day history of dyspnea. Chest X‐ray revealed a pleural effusion. We performed chest tube drainage, and then the patient experienced re‐expansion pulmonary edema. His respiratory distress improved after the treatment of noninvasive positive pressure ventilation and intravenous methylprednisolone.
Hernia formation after single‐stage umbilical vein marsupialization in three Percheron foals diagnosed with septic omphalophlebitis
Authors: Klein Chelsea , Caston Stephanie , Troy Jarrod 
Published: August 2022

AbstractSeptic omphalophlebitis is a common disease process with a variety of morbidities and possible mortality. Affected umbilical remnant resection is highly successful but may not always be possible. Umbilical marsupialization can be implemented when total resection cannot be accomplished with minimally reported complications. Umbilical vein marsupialization was performed on three Percheron foals with extensive septic omphalophlebitis using the one‐stage paramedian translocation technique and prolonged postoperative antimicrobial therapy. Long‐term follow‐up revealed herniation at the marsupialization site in all foals. Two foals were subsequently treated with herniorrhaphy at the prior marsupialization site. One foal died due to septic peritonitis with hernia formation 3 months after marsupialization. This case series highlights hernia formation as a potential complication following one‐stage umbilical vein marsupialization in foals diagnosed with septic omphalophlebitis and should be considered as a possible postoperative complication.
Selective leaching of lithium ions from LiFePO4 powders using hydrochloric acid and sodium hypochlorite system
Authors: Liu Wei , Li Kang , Wang Wei , Hu Yulei , Ren Zhongqi , Zhou Zhiyong 
Published: August 2022

AbstractHigh‐efficiency and selective leaching of lithium ions from spent lithium iron phosphate (LiFePO4) batteries is currently an urgent problem to be solved. Hydrochloric acid and sodium hypochlorite were used as acidic media and oxidant for recycling LiFePO4 powders based on the stoichiometric ratio. The effect of operation conditions on leaching performance was investigated. The leaching yield of Li and Fe were higher than 95% and lower than 0.1% within 20 min at 15°C. In addition, X‐ray diffraction, X‐ray photoelectron spectroscopy, scanning electron microscopy, and laser particle size analysis characterizations were applied for revealing the selective leaching mechanism, the results of which indicated that the crystal structure of powders remained basically unchanged during the leaching process. Finally, an efficient and cost‐effective recycling process for LiFePO4 powders was proposed, and lithium carbonate products with purity higher than 99.7% were obtained. The proposed recycling process shows strong industrial application potential for LiFePO4 powders.
Mesoporous Polydopamine‐Based Nanovehicles as a Versatile Drug Loading Platform to Enable Tumor‐Sufficient Synergistic Therapy
Authors: Jiang Suhua , Zhu Fukai , Ji Xiaoxuan , Li Jiaqi , Tian Haina , Wang Bingli , Lu Luanmei , Wang Peiyuan 
Published: August 2022

AbstractThe combination of photothermal therapy and chemotherapy are developing as a promising clinical strategy but it urgently needs the high exploration of intelligent multifunctional drug delivery nanovectors. In this paper, we used a versatile method to construct mesoporous polydopamine nanovehicles (MPDA) with the dendritic mesopores loaded with a clinical chemotherapeutic drug, Doxorubicin (MPDA@DOX). The monodisperse nanoagents are spherical with a size of ∼160 nm and pore size of approximately 10 nm. MPDA could efficiently delivery DOX with π‐π stacking interaction and acts as the potent photothermal agents. Importantly, MPDA@DOX are preferentially internalized by cancerous cells, then bursting drug release and local hyperthermia generation were observed in conditions representative of the cytoplasm in tumor cells that highly synergistic cell killing effect were found under 808 nm laser irradiation. The fluorescent imaging results of human breast tumor bearing murine model evidenced that MPDA delivery platform have excellent tumor precise targeting effect and in vivo tumor ablation experiment further revealed that MPDA@DOX showed markedly eradicated tumor growth capability under laser exposure. Therefore, this work provided a fascinating strategy based on biocompatible MPDA based drug delivery system for malignant tumors eradication via synergistic therapy.
Analysis of recent advancements in support vector machine
Authors: Bist Uttam Singh , Singh Nanhay 
Published: August 2022

SummaryThe current researches are primarily focused on optimizing the available classification methods in support vector machines (SVMs). The basic idea of this article to highlight the fundamentals of the proposed SVM variants and their optimization techniques. In this article, we have collectively identified the major issues in different variations of SVMs. This article has discussed a detailed explanation of the optimization and advancement of SVM and its kernel variants. The study elaborates on certain SVM optimization issues like model selection, novelty detection and so forth. In contrast, it discussed the identification of problems raises after every optimization and advancement of SVM. This is the first novel attempt to explain the optimization raises for SVMs. This article is about the majority of the necessary advancements in the optimization and cost‐effectiveness of computational algorithms of SVM with their detailed computational analysis. The approaches of such study helps to understand the optimization challenges in SVM.
Hollow Nanowire Constructed by NiCo Doped RuO2 Nanoparticles for Robust Hydrogen Evolution at High‐Current‐Density
Authors: Yi Hao , Zhang Xian , Ai Zhong , Song Shaoxian , An Qing 
Published: August 2022

AbstractLarge‐current‐density electrocatalytic water splitting is essential for industrial hydrogen production, but it is currently hindered by lacking active and robust hydrogen evolution reaction (HER) catalysts. Herein, a novel electrode of hollow nanowire arrays constructed by NiCo modified RuO2 nanoparticles on Ni foam (NiCo@RuO2 HNAs/NF) for high‐performance HER was reported. Such efficient electrode was fabricated by ion exchange with NF‐supported Ni modified cobalt carbonate hydroxide nanowire arrays template (Ni@CoCH NAs/NF). The formed NiCo@RuO2 HNAs/NF only needed overpotentials of 148.5 and 236.1 mV to deliver 500 and 1000 mA cm−2, respectively, along with excellent stability at the high‐current‐density for 300 h. Such remarkable HER performance was mainly attributed to the hollow structure with high surface area, hydrophilic feature, and NiCo@RuO2 with optimized hydrogen evolution kinetics. After coupling with anodic Ni@CoCH NAs/NF, our electrolyzer outperformed Pt/C–IrO2 and most other Ru‐based electrolyzers. This work provides a promising Pt alternative catalyst for profitable H2 production.
Deletion of ATAD3A inhibits osteogenesis by impairing mitochondria structure and function in pre‐osteoblast
Authors: Lee Hyeri , Kim Dae‐Won 
Published: August 2022

AbstractBackgroundATPase family AAA‐domain containing protein 3A (ATAD3A) is a nuclear encoded mitochondrial membrane protein that spans inner and outer membrane, and it has been shown to regulate mitochondrial dynamics and cholesterol metabolism. Since the mitochondrial functions have been implicated for osteogenic differentiation, a role of ATAD3A in skeletal development has been investigated.ResultsMesenchyme‐specific ATAD3 knockout mice displayed severe defects in skeletal development. Additionally, osteoblast‐specific deletion of ATAD3 in mice caused significant reduction in bone mass, while cartilage‐specific ATAD3 knockout mice did not show any significant phenotypes. Consistent with these in vivo findings, ATAD3A knockdown impaired mitochondrial morphology and function in calvarial pre‐osteoblast cultures, which, in turn, suppressed osteogenic differentiation in vitro.ConclusionsThe current findings suggest that ATAD3A plays a crucial role in mitochondria homeostasis, which is required for osteogenic differentiation during skeletal development.