bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent Mitral Regurgitation After MitraClip: Predictive Factors, Morphology, and Clinical Implication
Authors: Sugiura Atsushi , Kavsur Refik , Spieker Maximilian , Iliadis Christos , Goto Tadahiro , Öztürk Can , Weber Marcel , Tabata Noriaki , Zimmer Sebastian , Sinning Jan-Malte , Mauri Victor , Horn Patrick , Kelm Malte , Baldus Stephan , Nickenig Georg , Westenfeld Ralf , Pfister Roman , Becher Marc Ulrich 
Published: February 2022

Background:
Recurrent mitral regurgitation (MR) following MitraClip has not been thoroughly investigated. We aimed to examine the predictive factors, morphology, and long-term outcome of recurrent MR after MitraClip.

Methods:
We assessed data from the Heart Failure Network Rhineland registry from August 2010 to October 2018. Competing risk analyses were performed using the Fine and Gray model to assess the risk of recurrent MR.

Results:

Among 685 MitraClip patients with a reduction in MR to ≤2+, 61 patients developed recurrent MR within the first 12 months. Flail leaflet (hazard ratio, 3.68;
P
=0.002) and residual MR (MR grade 2+ versus ≤1+: hazard ratio, 2.56;
P
=0.03) were the predictors of recurrent MR in primary MR patients, while left atrial volume (per 10 mL increase: hazard ratio, 1.11;
P
<0.001) and residual MR (hazard ratio, 2.45;
P
=0.01) were independently associated with recurrent MR in secondary MR patients. In primary MR patients, loss of leaflet insertion or leaflet tear were the predominant morphologies with recurrent MR. In secondary MR patients, more than half of the patients with recurrent MR did not show any disorder of the clip or leaflets. Patients with recurrent MR were more likely to experience unplanned heart failure hospitalization or heart failure symptom with New York Heart Association scale III/IV (54.1% versus 37.8%;
P
=0.018) and undergo a repeat mitral valve intervention (9.8% versus 2.2%;
P
=0.005) during the follow-up. In the landmark survival analysis, patients with recurrent MR tended to have lower long-term survival (58.7% versus 83.9%;
P
=0.08) than patients without recurrent MR.

Conclusions:
Flail leaflet and residual MR were the predictors of recurrent MR in primary MR patients, while a larger left atrial volume and residual MR were associated with recurrent MR in secondary MR patients, which may be associated with long-term clinical outcomes of patients after MitraClip.
Glucose Metabolic Disorders Enhance Vascular Dysfunction Triggered by Particulate Air Pollution: a Panel Study
Authors: Chen Wu , Han Yiqun , Wang Yanwen , Chen Xi , Qiu Xinghua , Li Weiju , Xu Yifan , Zhu Tong 
Published: February 2022

Background:
Vascular dysfunction is a biological pathway whereby particulate matter (PM) exerts deleterious cardiovascular effects. The effects of ambient PM on vascular function in prediabetic individuals are unclear.

Methods:

A panel study recruited 112 Beijing residents with and without prediabetes. Multiple vascular function indices were measured up to 7 times. The associations between vascular function indices and short-term exposure to ambient PM, including fine particulate matter (PM
2.5
), ultrafine particles, accumulation mode particles, and black carbon, and the modification of these associations by glucose metabolic status were examined using linear mixed-effects models.

Results:
Increases in brachial artery pulse pressure, central aortic pulse pressure, and ejection duration, and decreases in subendocardial viability ratio and reactive hyperemia index were significantly associated with at least one PM pollutant in all participants, indicating increased vascular dysfunction. For example, for an interquartile range increment in 5-day moving average ultrafine particles, brachial artery pulse pressure, and central aortic pulse pressure increased 5.4% (0.8%–10.4%) and 6.2% (1.2%–11.5%), respectively. Additionally, PM-associated changes in vascular function differed according to glucose metabolic status. Among participants with high fasting blood glucose levels (≥6.1 mmol/L), PM exposure was significantly associated with increased brachial artery systolic blood pressure, central aortic systolic blood pressure, brachial artery pulse pressure, central aortic pulse pressure, and augmentation pressure normalized to a heart rate of 75 bpm and decreased subendocardial viability ratio and reactive hyperemia index. Weaker or null associations were observed in the low-fasting blood glucose group.

Conclusions:
Glucose metabolic disorders may exacerbate vascular dysfunction associated with short-term ambient PM exposure.
Error-related Alpha Suppression: Scalp Topography and (Lack of) Modulation by Modafinil
Authors: Schroder Hans S. , Iturra-Mena Ann M. , Breiger Micah , Linton Samantha R. , Robble Mykel A. , Kangas Brian D. , Bergman Jack , Nickels Stefanie , Vitaliano Gordana , Der-Avakian Andre , Barnes Samuel A. , Carlezon William A. , Pizzagalli Diego A. 
Published: February 2022

Abstract
Errors in performance trigger cognitive and neural changes that are implemented to adaptively adjust to fluctuating demands. Error-related alpha suppression (ERAS)—which refers to decreased power in the alpha frequency band after an incorrect response—is thought to reflect cognitive arousal after errors. Much of this work has been correlational, however, and there are no direct investigations into its pharmacological sensitivity. In Study 1 (n = 61), we evaluated the presence and scalp distribution of ERAS in a novel flanker task specifically developed for cross-species assessments. Using this same task in Study 2 (n = 26), which had a placebo-controlled within-subject design, we evaluated the sensitivity of ERAS to placebo (0 mg), low (100 mg), and high (200 mg) doses of modafinil, a wakefulness promoting agent. Consistent with previous work, ERAS was maximal at parieto-occipital recording sites in both studies. In Study 2, modafinil did not have strong effects on ERAS (a significant Accuracy × Dose interaction emerged, but drug–placebo differences did not reach statistical significance after correction for multiple comparisons and was absent after controlling for accuracy rate). ERAS was correlated with accuracy rates in both studies. Thus, modafinil did not impact ERAS as hypothesized, and findings indicate ERAS may reflect an orienting response to infrequent events.
Condillac and Derrida: Perception, the Human and Empiricism
Authors: Gaston Sean 
Published: February 2022

Abstract
In June 2020, a new work by Derrida on Condillac was published, Le Calcul des langues. This article re-examines Derrida’s readings of Condillac, focusing on the relation between perception and the language of signs; the relation between human knowledge and the animal; and the idealization and limits of empiricism.
Balancing the Indigenous Peoples’ Ancestral Sea Rights, and the State’s Obligation to Protect and Preserve the Marine Environment
Authors: Valdez Amiel Ian 
Published: February 2022

Abstract
There is a dynamic interplay between the State’s assertion of sovereignty over its territory, and the indigenous peoples’ claim over their traditionally owned seas. As experienced by the indigenous peoples in the Philippines and Australia, this dynamism is about lobbying for the recognition of their native title over ancestral seas, which includes their traditional fishing rights, and facing State interference with their affairs in managing these so-called sea countries. In this context, this article argues that there is sufficient basis for the recognition of an ancestral sea under the core human rights instruments, particularly through the lens of the indigenous peoples’ right to self-determination, right to enjoy or manifest culture, and right to protect their means of subsistence. It further argues that the State has a positive obligation to promote the realisation of ancestral rights, despite the Law of the Sea regime’s strong position on State sovereignty and sovereign rights, as well as a State duty in protecting and preserving the marine environment condition. Hence, there should be greater recognition of the role of indigenous peoples in managing the marine ecosystem of their ancestral seas.
Judicial Enforceability of Economic, Social and Cultural Rights in Bangladesh: A Critical Evaluation
Authors: Mohammad Nour , Hasan Sayed MM 
Published: February 2022

Abstract
The implementation of economic, social and cultural rights (esc rights) continues to pose uncertainties in the modern world. Given that many states constitutionally treat such rights as aspirational and not justiciable, it is difficult to enforce them judicially at the domestic level. Bangladesh has embodied these rights in Part ii of its Constitution as a social welfare goal of the State. This article takes Bangladesh as a case study and examines the international legal framework for the implementation of esc rights at the domestic level. Making a comparison with other jurisdictions, such as India and South Africa, the article examines the approach of the judiciary of Bangladesh (the Supreme Court) in giving effect to these rights. Lastly, the article argues that the court should devise appropriate and effective enforcement mechanisms for these rights.
Between Orthodoxy and Subjectivism
Authors: Aarvik Signe 
Published: February 2022

Abstract
This article investigates how beliefs and practices are legitimised among young (non- organised) Muslims in Norway. The findings confirm previous studies in showing how young Muslims in Europe often combine a discourse of submission to Islamic orthodoxy with a liberal vocabulary of autonomy and authenticity, although the tendency to divert from orthodoxy is more prevalent in this study. A variety of ways that young Muslims combine liberal and orthodox premises in their legitimisations are illustrated. The article argues that a high degree of engagement with pluralistic social contexts, including interreligious friendships, may challenge a previously dominant orthodox structure in the young Muslim’s outlook, partly because of the difficulty of maintaining an exclusivist stance that includes the possible damnation of non-Muslims. While this may lead to liberal discursive premises becoming dominant, examples are also given of how some young Muslims navigate an ambiguous position where both discursive structures are kept intact.
The Right to Political Representation for Members of National Minorities in the Republic of Croatia, 1990–2004
Authors: Mikucka-Wójtowicz Dominika 
Published: February 2022

The Right to Political Representation for Members of National Minorities in the Republic of Croatia, 1990–2004The goal of this article is to analyse the changes in the normative regulations concerning the political representation of members of national minorities in the Republic of Croatia in 1990–2004. These regulations are contrasted with their practical use. Furthermore, attention is turned to the political dimension of these issues, visible through the incessant amendments to regulations. The period from 1990 to 2004 was selected due to the fact that the first legal regulations governing this question were introduced in the Republic of Croatia in 1990, while 2004 saw the final constitution of the last bodies representing this group of citizens provided by law. Moreover, the author aims to prove that normative regulations on their own – even if favourable for minorities – are never sufficient to speak about protection of minority rights, if the good will to respect them in practice is missing. Prawo do reprezentacji politycznej dla członków mniejszości narodowych w Republice Chorwacji w latach 1990–2004Artykuł analizuje zmiany w regulacjach normatywnych dotyczących politycznej reprezentacji członków mniejszości narodowych w Republice Chorwacji w latach 1990–2004. Okres ten został wybrany z uwagi na fakt, iż w roku 1990 wprowadzono pierwsze regulacje normujące tę kwestię, natomiast w 2004 roku ostatecznie ukonstytuowały się ostatnie ustawowo przewidziane organy reprezentujące tę grupę obywateli. Celem autorki jest skontrastowanie regulacji na poziomie normatywnym z praktyką ich przestrzegania oraz pokazanie, iż same gwarancje normatywne nigdy nie są wystarczające, aby można było mówić o rzeczywistym zapewnieniu praw obywatelom. Ponadto uwaga została zwrócona na polityzację tej problematyki, czego przejawem były niewątpliwe ciągłe zmiany przepisów.
Koniec pewnej utopii, czyli o współczesnej sytuacji Ukraińców na Warmii i Mazurach
Authors: Żurko Jerzy 
Published: February 2022

The End of a Utopia: On the Contemporary Situation of Ukrainians in Warmia and MasuriaReview of: Bożena Domagała, Ukraińcy na Warmii i Mazurach: Studium procesów asymilacji [Ukrainians in Warmia and Masuria: A Study of Assimilation Processes], Olsztyn: Towarzystwo Naukowe i Ośrodek Badań Naukowych im. Wojciecha Kętrzyńskiego 2009. Koniec pewnej utopii, czyli o współczesnej sytuacji Ukraińców na Warmii i MazurachRecenzja: Bożena Domagała, Ukraińcy na Warmii i Mazurach: Studium procesów asymilacji, Olsztyn: Towarzystwo Naukowe i Ośrodek Badań Naukowych im. Wojciecha Kętrzyńskiego 2009.
Ruch „Dzwoniące cedry Rosji”. Strategie rekonstrukcji rosyjskiej tożsamości kulturowej
Authors: Mrozowicka Anna 
Published: February 2022

The Ringing Cedars of Russia Movement: Reconstructions of Russian Cultural IdentityThe paper presents the results of ethnographic research conducted in Russia in 2008, in Altai Krai, and in 2010, in its European part. The researcher observed the popularity of the new social movement known as the Ringing Cedars of Russia. Its formation was inspired by The Ringing Cedars Series, where the author, Vladimir Megre, chronicles his meetings with Anastasia, a woman with mysterious powers, in Siberian taiga. She leads him into a world of cosmic consciousness. She is able to solve even most complex social, health and environmental problems.The author refers to the Old Russian spiritual tradition – the institution of starets, influenced by Greek monasticism. It is related to the deeply rooted tradition of Russian apocalyptic and messianic elements, the idea of Russia’s great mission as the Holy Rus’, and the idea of Moscow as the Third Rome.Anastasia is also presented as an alien. She arrived from another planet on a spacecraft in order to pass on to people the saving message. Anastasia’s teaching is mostly focused on ecology which is strictly connected with feminism.A recurring theme throughout all of the books is creating the “Kin’s Domain”, or “Space of Love”, that is, a patch of family-owned land which is developed into a self-sustained type of mini farm. The series inspired many readers worldwide to abandon their old lifestyles in pursuit of a purer existence. These developments are commonly undertaken as part of an eco-village and they celebrate freedom from the unnatural pressure and stress of modern life. The aim is also to revive Slavic traditions (holidays, customs and habits).
Dyskretny urok wielokulturowości
Authors: Rauszer Michał 
Published: February 2022

The Discreet Charm of MulticulturalismReview of: Jerzy Nikitorowicz, Grupy etniczne w wielokulturowym świecie [Ethnic Groups in a Multicultural World], Sopot: Gdańskie Wydawnictwo Psychologiczne 2009. Dyskretny urok wielokulturowościRecenzja: Jerzy Nikitorowicz, Grupy etniczne w wielokulturowym świecie, Sopot: Gdańskie Wydawnictwo Psychologiczne 2009.
Wielokulturowość Europy Środkowo-Wschodniej. Kilka metodologicznych uwag o definiowaniu i badaniu zjawiska
Authors: Dolińska Kamilla , Makaro Julita 
Published: February 2022

The Multiculturalism of Central-Eastern Europe: Some Methodological Remarks on the Definition and Research of the PhenomenonThe article is a voice in the discussion over the state and prospects of modern research on multiculturalism. Taking into account the importance of this phenomenon in the contem­porary reality and a variety of approaches both to the way it is defined and to its numerous examples, this study makes an attempt to delineate multiculturalism as a complex socio-cultural phe­nomenon in the Central-Eastern European context, with all ethnic groups living in this area as its subjects. This complexity can be seen on four levels of multiculturalism: the level of “empirical state of affairs” (demographic), social awareness, the political one and the marketing one. The article makes a consistent connection between theoretical assumptions and methodological proposals, including the presentation of some guidelines taking into consideration the specifics of a particular level – a given research subject and the way of obtaining data, both qualitative and quantitative. As observed, the need to carry out – on various levels – research on multiculturalism in Central-Eastern Europe is also connected with reflection on the regional specifics of this phenomenon so that it avoids being treated as a “copy” of the Western European version.
Psychiatric Symptoms, Aggression, and Sexual Dysfunction Among Patients With Benign Anal Conditions
Authors: Akkoca Muzaffer , Kocaay Akin Firat , Tokgoz Serhat , Er Saadettin , Duman Berker , Ayaz Tugba , Kumbasar Hakan , Gokmen Derya , Koç Mehmet Ali , Kuzu Mehmet Ayhan 
Published: February 2022

Introduction The aim of this study was to investigate the incidence of general psychiatric symptoms, aggression levels, and sexual dysfunction in patients with benign anorectal diseases and compare the results with those of healthy control subjects. Methods We prospectively enrolled consecutive adult patients who presented for treatment of benign perianal diseases and healthy control subjects between June 2017 and December 2018. All patients had either grade 3 or 4 hemorrhoidal disease or perianal fistula with active discharge who had not undergone previous anorectal surgery. We also included a control group with benign subcutaneous lumps presenting for minor surgery. We used the Symptom Checklist-90-Revised Form to evaluate general psychiatric symptoms, the Buss-Perry Aggression Questionnaire (BPAQ) to evaluate aggression levels, and the Arizona Sexual Experiences Scale to evaluate sexual dysfunction. Results A total of 563 patients were assessed for eligibility; after exclusions, 94 with anal fistula, 89 with hemorrhoids, and 59 healthy control subjects were enrolled. The groups were similar with regard to age, gender, and educational level. Physical and verbal aggression, anger, and total BPAQ score were significantly higher in patients with perianal fistula than in those with hemorrhoidal disease and healthy control subjects ( P < .001). Conclusion This study suggests that patients with perianal fistula have higher levels of aggression than healthy control subjects and those with hemorrhoidal disease. One must bear this in mind during preoperative patient evaluations and obtaining informed consent. Further studies are needed to investigate the reason for this association and potential causality.
Gallic acid protects against isoproterenol-induced cardiotoxicity in rats
Authors: Shackebaei Dareuosh , Hesari Mahvash , Ramezani-Aliakbari Soudabeh , Hoseinkhani Zohreh , Ramezani-Aliakbari Fatemeh 
Published: February 2022

Background Gallic acid (GA) is a polyphenolic agent with interesting pharmacological impacts on the cardiovascular system. Objective The present study purposed to study the protective effects of GA at 25 and 50 mg/kg against isoproterenol (ISO)-induced cardiac damage in ischemia/reperfusion (I/R) in rats. Methods Male Wistar rats were randomly assigned into six groups: Control, Control treated with GA at 25 mg/kg (GA25), Control treated with GA at 50 mg/kg (GA50), Hypertrophic rats induced by ISO (ISO), Hypertrophic rats treated with GA at 25 mg/kg (ISO+GA25), and Hypertrophic rats treated with GA at 50 mg/kg (ISO+GA50). Heart isolation was performed to induce a cardiac I/R injury model. Cardiac hemodynamic parameters were recorded. Serum Lactate Dehydrogenase (LDH) and Creatine Kinase-MB (CK-MB) and cardiac Superoxide dismutases (SOD) levels were evaluated. The gene expression of Sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) was assessed. Results We found that GA at 50 mg/kg was significantly increased cardiac function at post I/R period in ISO-induced hypertrophic hearts. Moreover, it suppressed cardiac hypertrophy, the serum LDH and CK-MB levels in ISO injected rats. Administration of GA at 50 mg/kg was significantly increased SOD level and SERCA2a gene expression in the hypertrophic hearts. Conclusion GA at 50 mg/kg could improve cardiac performance possibly by increasing antioxidant defense enzymes, reducing cell damage, and enhancing SERCA2a gene expression in hypertrophic heart induced by ISO in I/R injury conditions.
The Impact of the Covid-19 Pandemic on Cleft Lip and Palate Service Delivery for New Families in the United Kingdom: Medical and Community Service Provider Perspectives
Authors: McWilliams Danielle , Costa Bruna , Blighe Sabrina , Swan Marc C. , Hotton Matthew , Hudson Nichola , Stock Nicola Marie 
Published: February 2022

Objectives Professionals in the United Kingdom providing care to new families affected by cleft lip and/or palate (CL/P) had to adapt to ensure families’ needs were met during a time of uncertainty due to Covid-19. The aims of this study were to explore the impacts of the pandemic on CL/P care provision for new families from the perspectives of professionals working in medical and community settings along with any personal impact on professionals and their reflections on the future of CL/P care. Design Semistructured interviews (n  =  27) were completed about experiences from March 2020 to October 2020 with consultant cleft surgeons (n  =  15), lead clinical nurse specialists (n  =  8), and staff working at the Cleft Lip and Palate Association (n  =  4). Transcripts were analyzed using inductive thematic analysis. Results Three themes were identified: (1) the impact of Covid-19 on the provision of cleft care in the United Kingdom, including working conditions, delays to treatment, and Covid-19 policies; (2) the impact of the pandemic on professionals’ mental health, including personal distress and concerns about Covid-19 exposure; and (3) reflections on the future of CL/P care, whereby professionals expressed both hope and concern about the Covid-19 recovery effort. Conclusions The ongoing Covid-19 pandemic has impacted CL/P service delivery for new families significantly, warranting recommendations for cohesive psychological support for families in addition to a safe and resourced recovery effort. Support for professionals is also suggested, following existing evidence-based models for providers’ needs that address the difficulties of working throughout challenging times.
Differentiation of Self, Life Span Theory, and Higher Stages of Human Development
Authors: Travis Frederick , Thompson Erik , Parim Nyazi 
Published: February 2022

What are the relationships among differentiation of self in Bowen theory, the object-referral/self-referral continuum of self in life-span development theory, and enduring self-states associated with peak experiences during meditation practice? Examining their interactions has practical implications: Can self-development in one system support development in others? Thirty-seven students were administered Skowron and Friedlander's Differentiation of Self Inventory (DSI) and the Survey of Peak Experiences (SPE), measuring frequency of momentary transcendent experiences during rest and enduring peak experiences during activity and sleep. Scores on the DSI in these subjects were similar to those in other adult populations. Between the two measures, there was a strong correlation between lower Fusion with Others and lower Emotional Reactivity on the DSI and higher peak experiences during rest and sleep on the SPE. Growth of the self-referral aspect of self, which is associated with peak experiences cultivated by transcendence, were meaningfully correlated with two subscales of differentiation of self.