bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water Dynamics in Competitive Solvation Assisted Loading of Colloidal Curcumin Nanoparticles onto Mesoporous Silica Nanostructures
Authors: Ananth A. Nitthin , Nagarajan V. , Kumar S. Suresh , Sasikumar P. , Chirico Giuseppe , D'Alfonso Laura , Jose Sujin P. 
Published: July 2022

AbstractThe main goal of this study is to develop methods for the simultaneous synthesis and loading of curcumin nanoparticles onto mesoporous silica by a sequential solvent evaporation approach. It is known that the presence of cosolvents and surfactants facilitates the homogenous formation of colloidal curcumin nanoparticles and enhances loading into mesoporous silica nanoparticles. The stability of the curcumin nanoparticles and their substantial loading are characterized as a function of the mesoporous silica nanostructures (MSN) surface properties, allowing to put into evidence how the dielectric nanoenvironment, largely determined by the water dynamics in the presence of cosolvents and of surfactants, plays a crucial role in the micelle mediated loading of curcumin nanoparticles into the mesoporous silica nanostructure. The interfacial hydrogen bonded corrugated network with its occupational electronic distribution shields the curcumin nanoparticles loaded onto the MSNs. Highly monodispersed nanostructures that are obtained that exhibit redox behavior, Fickian diffusion following linear compensation effect, and increased ionic activity triggered in an acidic pH ambiance. The augmented bioactivity of the human acute monocyte leukemia cancer cell line U937 elects the synthesized curcumin nanoparticles @ MSNs as a suitable nanostructure against acidic tumor microenvironment.
Extended bounded real lemma based sum of squares for static output feedback H∞ heading control
Authors: Huang Yanwei , Lin Tao , Huang Wenchao 
Published: July 2022

AbstractAim at the fore and aft asymmetry of unmanned surface vehicle (USV) and the loss of linear velocity, a static output feedback (SOF) control method is proposed by the sum of squares (SOS) based on two types of extended bounded real lemmas (EBRL) for heading regulation to guarantee the robustness and improve the rapidity. First, an asymmetric nonlinear heading error model with hydrodynamic parameters is established by the consideration of lack of linear velocity. Second, SOF controller with performance is presented for the asymmetric nonlinear USV model, and it's SOS conditions to solve controller parameters is deduced from EBRL by homogeneous Lyapunov function (HERBL) to maintain the system robustness. Further, the solution of SOF controller relies on the state feedback gain matrix, EBRL is deduced by quadratic Lyapunov function (QEBRL) to obtain the SOS conditions without the addition of an extended matrix to cut computing cost for the solution of the state feedback gain matrix. Finally, the heading control simulations for USV indicate that, QEBRL method takes less time for SOS conditions to solve the state feedback gain matrix, and SOF system of HERBL has a superior performance on the transient response and the robustness.
Preparation, Characterization and Anticancer Activity of Inclusion Complexes between Genistein and Amino‐Appended β‐Cyclodextrins
Authors: Zhang Yazhou , Kong Lingguang , Zhu Panyong , Liu Qingmeng , Liao Xiali , Si Tian , Yang Bo 
Published: July 2022

AbstractGenistein (Gen) has great potential in the field of anti‐tumor, however, its low solubility in water, serious biotoxicity on thyroid function and estrogenic effects limit its further clinical application. Host‐guest inclusion complex based on supramolecular chemistry could be a promising strategy to address these issues. During last decades, cyclodextrin as one of the most popular supramolecular hosts have been considered as a promising drug delivery carrier. Herein, the host‐guest encapsulation system of Gen with amino‐appended β‐cyclodextrins (ACDs) were reported, and inclusion complexes have been characterized by 1H and 2D‐ROESY nuclear magnetic resonance (NMR), Phase solubility curve, Fourier transform infrared spectroscopy (FT‐IR), X‐ray powder diffraction (XRD) and scanning electron microscopy (SEM). The results showed that Gen was successfully encapsulated into the cavities of ACDs to form the complexes with 1 : 1 stoichiometry, and compared with free Gen, the aqueous solubility of the complexes was enhanced by 1000 folds. In addition, the cytotoxicity of their complexes to tumor cell line HEK293T was significantly improved. These results will be potentially useful for the development of further clinical application of genistein‐based anticancer agent.
Nanomaterials: An Efficient Support to Immobilize Microbial α–Amylases for Improved Starch Hydrolysis
Authors: Kikani Bhavtosh A. , Suthar Sadikhusain , Joshi Disha 
Published: July 2022

AbstractMicrobial enzymes have contributed significantly to the development of biotech based industries over the recent past. Importantly, the microbial α‐amylases share a major market along with proteases. Starch gets hydrolyzed to dextrin, maltotetroses, maltotrioses, maltose, and glucose in trace amount using amylases. To be suitable commercially, the amylase should be stable at higher temperatures and a wide range of pH values. Moreover, it should also exhibit resistance against a range of chelators, surfactants, and denaturants. It is quite strenuous to isolate an amylase harboring all the required qualities. Therefore, various strategies have been employed to achieve the required attributes. In the present mini‐review, amylase immobilization on conventional matrices as well as on different types of nanomaterials has been discussed with a special emphasis on improvement in the stability and reusability. The stability of the nanomaterials against various physical, chemical, and biological stress is a key factor to be explored commercially. The mini‐review includes mainly magnetite, non‐magnetite, and hybrid (organic–inorganic) nanomaterials. Conclusively, it is anticipated that the advanced strategies would help to overcome the technical barriers in the industrial sectors for better continuous applications of microbial amylases.
Integrated proteomic analysis to explore the molecular regulation mechanism of IL‐33 mRNA increased by black carbon in the human endothelial cell line EA.hy926
Authors: Jiang Wanyu , Chu Hongqian , Li Zekang , Ge Jianhong , Wang Xiaoyun , Jiang Jianjun , Xiao Qianqian , Meng Qinghe , Lou Yaxin , Hao Weidong , Wei Xuetao 
Published: July 2022

AbstractBlack carbon (BC) correlates with the occurrence and progression of atherosclerosis and other cardiovascular diseases. Increasing evidence has demonstrated that BC could impair vascular endothelial cells, but the underlying mechanisms remain obscure. It is known that IL‐33 exerts a significant biological role in cardiovascular disease, but little is known about the molecular regulation of IL‐33 expression at present. We first found that BC significantly increased IL‐33 mRNA in EA.hy926 cells in a concentration and time‐dependent manner, and we conducted this study to explore its underlying mechanism. We identified that BC induced mitochondrial damage and suppressed autophagy function in EA.hy926 cells, as evidenced by elevation of the aspartate aminotransferase (GOT2), reactive oxygen species (ROS) and p62, and the reduction of mitochondrial membrane potential (ΔΨm). However, ROS cannot induce IL‐33 mRNA‐production in BC‐exposed EA.hy926 cells. Further, experiments revealed that BC could promote IL‐33 mRNA production through the PI3K/Akt/AP‐1 and p38/AP‐1 signaling pathways. It is concluded that BC could induce oxidative stress and suppress autophagy function in endothelial cells. This study also provided evidence that the pro‐cardiovascular‐diseases properties of BC may be due to its ability to stimulate the PI3K/AKT/AP‐1 and p38/AP‐1 pathway, further activate IL‐33 and ultimately result in a local vascular inflammation.
Low concentration triphenyl phosphate fuels proliferation and migration of hepatocellular carcinoma cells
Authors: Ye Liang , Zhang Xu , Wang Peng , Zhang Ying , He Shujiao , Li Yang , Li Shao , Liang Kangyan , Liao Shuguang , Gao Yi , Zhou Shuqing , Peng Qing 
Published: July 2022

AbstractOrganophosphate flame retardants (OPFRs) have been widely used due to their unique properties. The OPFRs are mainly metabolized in the liver. However, whether the plasma level of OPFRs was involved in the progression of liver cancer remains unclear. Triphenyl phosphate (TPP) is one of the OPFRs that are mostly detected in environment. In this study, we performed CCK8, ATP, and EdU analyses to evaluate the effect of TPP at the concentrations at 0.025–12.8 μM on the proliferation, invasion, and migration of Hep3B, a hepatocellular carcinoma (HCC) cell line. Tumor‐bearing mouse model was used for in vivo validation. The results showed that low concentrations of TPP at (0.025–0.1 μM), which are obtained in the plasma of patients with cancers, remarkably promoted cell invasion and migration of Hep3B cells. Animal experiments confirmed that TPP treatment significantly enhanced tumor growth in the xenograft HCC model. To explore the possible molecular mechanisms that might mediate the actions of TPP on Hep3B cells, we profiled gene expression in groups treated with or without TPP at the concentrations of 0.05 and 0.1 μM using transcriptional sequencing. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, and Protein–protein interaction (PPI) analyses demonstrated that pathways affected by differentially expressed genes (DEGs) were mainly in nuclear‐transcribed mRNA catabolic processes, cytosolic ribosome, and ATPase activity. A 0.05 and 0.1 μM TPP led to up‐regulation of a series of genes including EREG, DNPH1, SAMD9, DUSP5, PFN1, CKB, MICAL2, SCUBE3, and CXCL8, but suppressed the expression of MCC. These genes have been shown to be associated with proliferation and movement of cells. Taken together, our findings suggest that low concentration of TPP could fuel the proliferation, invasion, and migration of HCC cells. Thus, TPP is a risk factor in the progression of HCC in human beings.
Indeterminate pediatric acute liver failure: Clinical characteristics of a temporal cluster of five children in the Netherlands in the spring of 2022
Authors: Lexmond Willem S. , de Meijer Vincent E. , Scheenstra René , Bontemps Sander T. H. , Duiker Evelien W. , Schölvinck Elisabeth H. , Zhou Xuewei , von Eije Karin J. , Reyntjens Koen M. E. M. , Verkade Henkjan J. , Porte Robert J. , de Kleine Ruben H. 
Published: July 2022

AbstractThere is increasing global concern of severe acute hepatitis of unknown etiology in young children. In early 2022, our center for liver transplantation in the Netherlands treated five children who presented in short succession with indeterminate acute liver failure. Four children underwent liver transplantation, one spontaneously recovered. Here we delineate the clinical course and comprehensive diagnostic workup of these patients. Three of five patients showed a gradual decline of liver synthetic function and had mild neurological symptoms. Their clinical and histological findings were consistent with hepatitis. These three patients all had a past SARS‐CoV‐2 infection and two of them were positive for adenovirus DNA. The other two patients presented with advanced liver failure and encephalopathy and underwent dialysis as a bridge to transplantation. One of these children spontaneously recovered. We discuss this cluster of patients in the context of the currently elevated incidence of severe acute hepatitis in children.
Running Systems Mapping Workshops
Authors: Barbrook-Johnson Pete , Penn Alexandra S. 
Published: July 2022

AbstractThis chapter explores the practicalities of organising and facilitating systems mapping workshops. It considers how you should plan them; how to choose venues, materials, and technology; how to record them; and how to improve your facilitation skills. It provides readers with guidance for dealing with some common issues, such as power dynamics, disagreement, confusion, disengagement, and facilitator burnout, and points to useful resources for specific methods.
Bayesian Belief Networks
Authors: Barbrook-Johnson Pete , Penn Alexandra S. 
Published: July 2022

AbstractThis chapter overviews Bayesian Belief Networks, an increasingly popular method for developing and analysing probabilistic causal models. We go into some detail to develop an accessible and clear explanation of what Bayesian Belief Networks are and how you can use them. We consider their strengths and weaknesses, outline a brief history of the method, and provide guidance on useful resources and getting started, including an overview of available software.
Open Questions
Authors: Rehmann-Sutter Christoph , Jürgensen Martina , Herzog Madeleine , Schües Christina 
Published: July 2022

AbstractThe families we approached have two exceptional things in common: they all experienced the dramatic event of a life-threatening disease such as leukaemia affecting one of their children; and, in all of these families, that child was treated with a stem cell transplant taken from a sibling’s body. In this last chapter of the book we reflect very briefly on our interview experiences, analysis, and discussions. In the end, we identify open questions and further areas which may invite further research.
A Donor by Coincidence or by Conception – My Sister’s Keeper Revisited
Authors: Rehmann-Sutter Christoph , Schües Christina 
Published: July 2022

AbstractThirteen-year-old Anna Fitzgerald has been conceived in order to be a matching donor for her older sister Kate, who has a rare form of leukaemia. The story in the novel “My Sister’s Keeper” by Jody Picoult, and Nick Cassavetes’ movie, has many striking similarities to the situations that we heard from the families we studied – despite one significant difference: Anna is created to be a saviour sibling, whereas the stem cell donors we interviewed already existed and were found to be matching. We discuss the film as an emotionally complex, multi-layered narrative that gives insight into the perspectives of different family members and into some key aspects of a paradigmatic family conflict. The temporal order of the film’s story-telling using multiple flash-backs and retakes represents the entangled temporalities of experience and memory.
Mediating the Risks of Mutual Care: Families and the Ethical Challenges of Sibling Bone Marrow Donation
Authors: Wiesemann Claudia 
Published: July 2022

AbstractBone marrow transplants from one sibling to another are a challenge for medical ethics. How can the decision to donate be made freely and without coercion if the life of a child depends on it? I examine how sibling bone marrow donation can be reconciled with the moral ideal of family, specifying the meaning of care, and focusing particularly on the role of minors. I also take the example of intrafamily bone marrow transplantation as a test case to identify the dangers of care and ask how to best mediate them.
Introduction
Authors: Rechnitzer Tanja 
Published: July 2022

AbstractReflective equilibrium (RE) is widely regarded as an important philosophical method—yet despite this high regard, we find strikingly few cases in which it is actually and explicitly applied. This chapter introduces the main ideas of reflective equilibrium, gives an overview about how it has been applied so far, and identifies desiderata for a case study on the applicability of reflective equilibrium as a method. I argue that the justification of a precautionary principle (PP) provides ideal content for such a case study: PPs are intended as principles that guide decisions concerning threats of uncertain, but potentially serious or even catastrophic harm. While the basic idea of PPs—“better safe than sorry”—is intuitively plausible, it is contested how it should be spelled out as a normative principle. It thus provides an ideal case to test whether RE can indeed be used to provide clarification and justification of philosophical principles and theories.
SIO Multiplier Analysis
Authors: Rohne Till Emelie 
Published: July 2022

AbstractThis chapter presents the main results of the Semi-Input-Output (SIO) multiplier analysis. Overall, the results of the empirical analysis show that the agricultural sector was the best growth option in Ethiopia in the studied time period, with high and strengthening growth linkages to other sectors. Due to the apparent rigidity of the manufacturing sector, manufacturing growth would not have had as strong an effect on overall growth. These results are presented in detail, as well as discussed, in this chapter.
Universal Access Panel: A Novel Approach for Accessible Smart Homes and IoT
Authors: Veigl Christoph , Klaus Benjamin , Aigner Benjamin , Wagner Manuel 
Published: July 2022

AbstractAlthough various standards and guidelines for accessible design exist, many modern digital devices lack even basic accessibility features. In particular, touchscreens without haptic feedback and a highly complex menu navigation impose serious hurdles for many people – especially for people with disabilities and elderly persons. In this work, we present the Universal Access Panel (UAP) for enabling barrier-free access to home appliances and IoT devices. The system offers a novel, radically simple, multimodal user interface consisting of just a few interaction elements for accessing dedicated functions of the connected home. Using established APIs and communication protocols such as HomeConnect or OpenHab, various domestic appliances, consumer products and smart home devices can be controlled from a single, multimodal interaction console. The system has been designed in cooperation with visually impaired accessibility experts and a user study was conducted with people from the target group. The results show a high overall usability of the prototype.
Accessible User Interface Concept for Business Meeting Tool Support Including Spatial and Non-verbal Information for Blind and Visually Impaired People
Authors: Koutny Reinhard , Miesenberger Klaus 
Published: July 2022

AbstractBusiness meetings play an essential role in many people’s work life. Although, business meetings have changed over time, especially tools, which are used to support the process, slowly moving from traditional means like flipcharts to more modern, digital alternatives, some aspects stayed the same: Visual information is used to gather thoughts, support arguments and lead the discussion. These kinds of information used to be completely inaccessible to blind and visually impaired people (BVIP) and still are, for the most part. Even though, the movement towards digitalization facilitates accessibility, no fully accessible tool support for business meetings is available. Additionally, non-verbal communication and spatial information is heavily used as well. People use mimic and gestures, and they refer to objects or other people by pointing at them. BVIP miss out on this type of information as well. Ultimately, BVIP have a significant disadvantage during business meetings and very often during their entire professional life. Research efforts have tried to mitigate single aspects of this situation, but no comprehensive user interface approach has be developed. This paper presents a user interface approach, as part of the MAPVI project [1], that allows BVIP access visual, non-verbal and spatial information of business meetings in a user-friendly manner, using only off-the-shelf hardware. Additionally, it presents results of user tests of this novel user interface.
Kontextuelle Einbettung und Hintergründe des Buches
Authors: Schütte Patricia M. , Schönefeld Malte , Schulte Yannic , Dittmer Cordula , Lorenz Daniel F. , Frommer Jana-Andrea , Fiedrich Frank 
Published: July 2022

ZusammenfassungKatastrophen, Krisen, Unglücksfälle – sie stehen für kritische Ereignisse und Phasen, die binnen kurzer Zeit das gesellschaftliche Geschehen beherrschen und vor große Herausforderungen stellen. Neben den sofortigen Auswirkungen zeichnen sie sich oft durch nachhaltige Konsequenzen aus, die auch Jahre nach dem eigentlichen Ereignis noch abge- und verarbeitet werden müssen. Manchmal werden diese Wiederaufbau- und Nachbereitungsphasen bereits von weiteren Krisen und Katastrophen überschattet, obwohl deren Abschluss längst noch nicht in Sicht ist.
Fazit
Authors: Schulte Yannic , Schütte Patricia M. , Schönefeld Malte , Fiedrich Frank 
Published: July 2022

ZusammenfassungOb in Bezug auf Unglücke, Krisen oder Katastrophen: Die an der Lagebewältigung beteiligten Akteure haben in der Regel weder währenddessen noch im Nachgang ausreichend Personal, Zeit und Geld, um die Aufarbeitung selbst intern und akteursübergreifend sicherzustellen und nachhaltig zu gestalten. Das gilt so z. B. auch für die Flüchtlingssituation 2015/2016, aber auch für andere ähnliche kritische Situationen. Das Ihnen vorliegende Buch verfolgt daher das Ziel, dem offensichtlichen Bedarf aus der Krisenmanagementpraxis nachzukommen.
RG-induced modulus stabilization: perturbative de Sitter vacua and improved D3-$$ \overline{\mathrm{D}3} $$ inflation
Authors: Burgess C. P. , Quevedo F. 
Published: July 2022

Abstract
We propose a new mechanism that adapts to string theory a perturbative method for stabilizing moduli without leaving the domain of perturbative control, thereby evading the ‘Dine-Seiberg’ problem. The only required nonperturbative information comes from the standard renormalization-group resummation of leading logarithms that allow us simultaneously to work to a fixed order in the perturbative parameter α and to all orders in α ln τ where τ is a large extra-dimensional modulus. The resulting potential is naturally minimized for moduli of order τ ~ e1/α and so can be exponentially large given $$ \mathcal{O} $$
O
(10) input parameters. The mechanism relies on accidental low-energy scaling symmetries known to be generic and so is robust against UV details. The resulting compactifications generically break supersymmetry and 4D de Sitter solutions are relatively easy to achieve without additional uplifting. Variations on the theme lead to inflationary scenarios for which the size of the stabilized moduli differ significantly before and after inflation and so provide a dynamical mechanism whereby inflationary scales are much larger than late-time physical (e.g. supersymmetry breaking) scales, with this hierarchy contingent on past cosmic evolution with the inflaton playing a secondary late-time role as a relaxation field. We apply this formalism to warped D3-$$ \overline{\mathrm{D}3} $$

D
3

¯

inflation using non-linearly realized supersymmetry to describe the antibrane tension and the Coulomb interaction, and show how doing so our perturbative modulus stabilization mechanism evades the η-problem that usually plagues this scenario. We speculate about the relevance of our formalism to tachyon condensation at later stages of brane-antibrane annihilation.
Frontiers of CO2 Capture and Utilization (CCU) towards Carbon Neutrality
Authors: Zhang Lingyun , Song Yanfang , Shi Jialin , Shen Qun , Hu Deng , Gao Qiang , Chen Wei , Kow Kien-Woh , Pang Chengheng , Sun Nannan , Wei Wei 
Published: July 2022

AbstractCO2 capture, utilization, and storage (CCUS) technology is a rare option for the large-scale use of fossil fuels in a low-carbon way, which will definitely play a part in the journey towards carbon neutrality. Within the CCUS nexus, CCU is especially interesting because these processes will establish a new “atmosphere-to-atmosphere” carbon cycle and thus indirectly offer huge potential in carbon reduction. This study focuses on the new positioning of CCUS in the carbon neutrality scenario and aims to identify potential cutting-edge/disruptive CCU technologies that may find important application opportunities during the decarbonization of the energy and industrial system. To this end, direct air capture (DAC), flexible metal-framework materials (MOFs) for CO2 capture, integrated CO2 capture and conversion (ICCC), and electrocatalytic CO2 reduction (ECR) were selected, and their general introduction, the importance to carbon neutrality, and most up-to-date research progress are summarized.