bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penggunaan Aplikasi BuzzBreak Perspektif Hukum Islam
Authors: Lailatul Hanifah Umi , Rofiah Khusniati 
Published: March 2022

This research used the BuzzBreak Application in Bungkuk Magetan Village. The purpose of this study is to explain the principles of Islamic law on contracts and the mechanism for using BuzzBreak, then the application of Islamic law on passive income using BuzzBreak in Bungkuk Magetan Village. The qualitative research method was used, with data collection techniques through interviews and documentation. From this research, the key is that the contract and mechanism for the BuzzBreak application in Bungkuk Magetan Village have met the terms and conditions of the ju'ālah contract. It is mainly the official BuzzBreak application from the Google Play Store. The mechanism for using the BuzzBreak application from a website that has implemented it does not meet the requirements. One condition of the ju'ālah contract is that the benefits made by the actor ('āmil) must have a value for their efforts (kulfah), because work that does not have the value of hard work is not worthy of being commercialized according to sharia. Meanwhile, the bonus given to the BuzzBreak application according to the DSN-MUI Fatwa No. 75/DSN-MUI/VII/2009 Regarding Sharia Tiered Direct Selling is not appropriate because there are still bonuses that can be obtained without carrying out the missions in the BuzzBreak application.
Penelitian ini berangkat dari praktik penggunaan Aplikasi BuzzBreak di Desa Bungkuk Magetan. Tujuan penelitian ini untuk menjelaskan tinjauan hukum Islam terhadap akad dan mekanisme penggunaan aplikasi BuzzBreak dan tinjauan hukum Islam terhadap passive income pada penggunaan aplikasi BuzzBreak di Desa Bungkuk Magetan. Metode penelitian yang digunakan adalah metode kualitatif, dengan teknik pengumpulan data melalui wawancara dan dokumentasi. Dari penelitian ini disimpulkan bahwa akad dan mekanisme aplikasi BuzzBreak di Desa Bungkuk Magetan menurut hukum Islam telah memenuhi rukun dan syarat dari akad ju’ālah terutama aplikasi BuzzBreak yang resmi dari Google Play Store, sedangkan untuk mekanisme penggunaan aplikasi BuzzBreak dari website yang sudah dimodifikasi belum memenuhi salah satu syarat dari akad ju’ālah yaitu manfaat yang dikerjakan pelaku (‘āmil) harus ada nilai jerih-payahnya (kulfah), sebab pekerjaan yang tidak ada nilai jerih-payahnya, tidak layak dikomersilkan secara syar’i. Sedangkan pemberian bonus pada aplikasi BuzzBreak menurut Fatwa DSN-MUI No. 75/DSN-MUI/VII/2009 Tentang Penjualan Langsung Berjenjang Syariah belum sesuai karena masih ada bonus yang diperoleh secara pasif tanpa menjalankan misi yang ada di aplikasi BuzzBreak.
Prognostic model including the combination of platelet count and neutrophil–lymphocyte ratio for metastatic renal cell carcinoma treated with sunitinib
Authors: Sato Miki Takenaka , Ida Ayuki , Kanda Yuki , Takano Kaori , Ohbayashi Masayuki , Kohyama Noriko , Morita Jun , Fuji Kohzo , Sasaki Haruaki , Ogawa Yoshio , Kogo Mari 
Published: March 2022

Abstract
BackgroundThe association between the combination of platelet count and neutrophil–lymphocyte ratio (COP-NLR) at the time of adverse events during sunitinib treatment and prognosis is unclear, and prognostic models combining the prognostic factors of sunitinib have not been well studied. To develop a prognostic model that includes the COP-NLR to predict the prognosis of patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib.MethodsWe performed a retrospective cohort study of 102 patients treated with sunitinib for mRCC between 2008 and 2020 in three hospitals associated with Showa University, Japan. The primary outcome was overall survival (OS). The collected data included baseline patient characteristics, adverse events, laboratory values, and COP-NLR scores within the first 6 weeks of sunitinib treatment. Prognostic factors of OS were analyzed using the Cox proportional hazards model. The integer score was derived from the hazard ratio (HR) of these factors and was divided into three groups. The survival curves were visualized using the Kaplan–Meier method and estimated using a log-rank test.ResultsThe median OS was 32.3 months. Multivariate analysis showed that the number of metastatic sites, Memorial Sloan Kettering Cancer Center risk group, number of metastases, hypertension, modified Glasgow Prognostic Score, and 6-week COP-NLR were significantly associated with OS. A higher 6-week COP-NLR was significantly associated with a shorter OS (p < 0.001). The HRs of the five factors for OS were scored (hypertension, mGPS, and 6-week COP-NLR=1 point; number of metastatic sites=2 points; MSKCC risk group=3 points) and patients divided into three groups (≤1, 2–3, and ≥4). The low-risk (≤1) group had significantly longer OS than the high-risk (≥4) group (median OS: 99.0 vs 6.2 months, p < 0.001).ConclusionsThe 6-week COP-NLR, which was associated with OS, was an important prognostic factor in patients with mRCC treated with sunitinib. The developed prognostic model for OS, including the 6-week COP-NLR, will be useful in decision-making to continue sunitinib in the early treatment stage of patients with mRCC.
A case report: CD8 + aggressive cutaneous epidermotropic T cell lymphoma (ACLAE), a rare and ill-defined subtype
Authors: Boujguenna Imane Mohamed , Haouane Mohamed Amine , Marhoume Fatimazahra , Bahbouhi Imane , Rody Kenza Kandri , Hocar Ouafa , Amal Said , Rais Hanane , Belbachir Anass 
Published: March 2022

Abstract
Background: Aggressive" CD8+ cutaneous epidermotropic T-lymphoma is a rare entity belonging to the group of cutaneous lymphomas with a cytotoxic T/NK phenotype and which is characterized by: rapidly evolving tumor lesions at the onset, keratinocyte necrosis, a cytotoxic T immunophenotype and an unfavorable prognosisCase presentation: In this study, we report the case of a A 36-year-old patient with no notable pathological history, presenting a rash made up of plaques evolving for 6 months, associated with scalp lesion and alopecia.Conclusion: LCEA CD8 + is a lymphoma with a poor prognosis, despite the use of aggressive chemotherapy drugs. The use of gemcitabine, pralatrexate, brentuximab, as well as allogeneic stem cell transplantation seems to open up new therapeutic avenues.
Pollution for p romotion： Does senior government leaders'green attention matter？
Authors: Yang Xue , Zhang Peng 
Published: March 2022

Abstract
Does the green attention of senior government leaders reinforce the relationship between environmental performance and local officials’ promotion? To examine the factors that might influence this issue in China, we builds a theoretical linkage between senior government leaders’ green attention and the green governance of officials. Inter-provincial panel data from 2001-2016 were used to examine how the green attention of senior government officials alters political incentives and influences the environmental governance behaviour of local officials. We find that the dualistic logic of local governments’ environmental governance lies in the green attention allocation of senior government leaders. When senior government leaders pay more attention to environmental governance, local officials are more likely to be motivated to govern the environment. As the effect of environmental governance in officials’ jurisdictions is significantly improved, their promotion probability increases as well. We also accounts for the degree of attention allocation variables, and the results suggest that greater environmental pollution reduces the prospect of officials’ promotion, but this effect is significantly negative only in years with a high level of attention allocation.
Evaluation of rock mass permeability along a borehole by integrating the techniques of geological features and logistic regression: A case study in Taiwan
Authors: Hsu Shih-Meng , Liao Yi-Fan , Dong Ming-Chia 
Published: March 2022

Abstract
When the budget for in-situ hydraulic tests is constrained, cost-effective approaches for determining the variations in hydraulic conductivity along a borehole remain enticing for helping design and planning of groundwater-related engineering systems. This study proposes a practical method with probabilistic outputs for fulfilling engineering concerns. First, 474 sets of hydrogeological investigation and hydraulic test data of fractured rock masses in most of the watersheds of mountainous areas of Taiwan were collected. Then, seven geological indices (rock quality design (RQD), depth index (DI), gouge content design (GCD), lithology permeability index (LPI), fracture density (FD), fracture width (FW), and groundwater velocity (GV)) significantly correlated with rock mass permeability were identified. Third, using logistic regression analysis, the seven indices were used as explanatory variables, and the hydraulic conductivity was utilized as an outcome variable (its threshold value is 1 × 10− 6 m/s) for developing prediction models of high groundwater potential zones along a borehole. All indices passed the multicollinearity test, indicating no collinearity between the indices. To make the prediction models proposed more flexible in practical applications, a total of 127 combinations based on the combination selection of seven explanatory variables were explored to develop various prediction models. Through the validation of the Hosmer-Lemeshow test, Omnibus test, and Wald test for all developed models, only 77 models were statistically significant. The 77 models were evaluated by three measures of Nagelkerke R2, SR (success rate), and AUC (area under the curve) to further understand the prediction performance of each model. The results show that the accuracy of the prediction model is positively correlated with the number of geological indices used. When all seven geological indices are used, Nagelkerke R2, SR, and AUC can reach the best values, which are 0.83, 91.6%, and 0.976, respectively. In conclusion, the prediction model developed by combining geological indices with logistic regression analysis can provide a more efficient way of understanding the hydrogeological conditions of a borehole site.
FBXL17/Spastin Axis As A Novel Therapeutic Target of Hereditary Spastic Paraplegia
Authors: Kang Hyun Mi , Kim Mijin , Min Yoohong , Jeong Bohyeon , Noh Kyung Hee , Lee Da Yong , Cho Hyun-Soo , Kim Dae Hun , Kim Nam-Soon , Jung Cho-Rok , Lim Jung Hwa 
Published: March 2022

Abstract
Background Spastin significantly influences microtubule regulation in neurons and is implicated in the pathogenesis of hereditary spastic paraplegia (HSP). However, post-translational regulation of the spastin protein remains nebulous. The association between E3 ubiquitin ligase and spastin provides a potential therapeutic strategy. ResultsAs evidenced by protein chip analysis, FBXL17 inversely correlated with SPAST-M1 at the protein level in vitro and, also in vivo during embryonic developmental stage. SPAST-M1 protein interacted with FBXL17 specifically via the BTB domain at the N-terminus of SPAST-M1. The SCFFBXL17 E3 ubiquitin ligase complex degraded SPAST-M1 protein in the nuclear fraction in a proteasome-dependent manner. SPAST phosphorylation occurred only in the cytoplasmic fraction and was involved in poly-ubiquitination. Inhibition of SCFFBXL17 E3 ubiquitin ligase by small chemical and siRNA-FBXL17 decreased proteasome-dependent degradation of SPAST-M1 and induced axonal extension. The Y52C SPAST mutant, harboring abnormality in BTB domain could not interact with FBXL17, thereby escaping protein regulation by the SCFFBXL17 E3 ubiquitin ligase complex, resulting in loss of functionality with aberrant quantity. Although this mutant showed shortening of axonal outgrowth, low rate proliferation, and poor differentiation capacity in a 3D model, this phenotype was rescued by inhibiting SCFFBXL17 E3 ubiquitin ligase. ConclusionsWe discovered that a novel pathway, FBXL17-SPAST was involved in pathogenicity of HSP by the loss of function and the quantitative regulation. This result suggested that targeting FBXL17 could provide new insight into HSP therapeutics.
Phylogenetic study of Enterobius vermicularis isolates from Northwest of Iran
Authors: Shilanabadi Kaveh Figh , Derakhshan Fatemeh Khadivi , Raeghi Saber 
Published: March 2022

Abstract
Human infection with Enterobius vermicularis occurs worldwide, particularly in children. The Role of E. vermicularis in appendicitis is proven. was aimed at characterization and genotyping f this parasite from different samples inferred by mitochondrial DNA to get the parasitic gene flow among diverse populations. There were 40 appendectomies for acute clinical appendicitis, 40 positive scotch tape samples, and an adult female worm isolated from Urmia and Maragheh in the northwest of Iran. Genetic differentiation, haplotype network analysis, and isolates' population structure were analyzed based on cytochrome C oxidase subunit 1 (cox1) gene. It has been demonstrated that all isolations in the appendectomies specimens are similar, and the genetic difference divergence is seen in adult worm specimens. The neutral indices of the samples of Azerbaijan did not show a significant difference and show that there is no intraspecific and population distribution diversity. Our samples show different haplotypes in the B type of E. vermicularis population and add new information about genotyping of these parasites in Iran. In comparison with other studies, intraspecific variation of this parasite from Iran was observed.
RSEA-Net: Residual Squeeze and Excitation Attention Network for Medical Image Segmentation
Authors: Liang Shufen , Wang Tian , Chen Chen , Liu Huilin , Qin Chuanbo , Feng Yue 
Published: March 2022

Abstract
Background
In recent years, convolutional neural networks have been prominent in medicine image processing, but single convolution and frequent pooling operations very easily produce redundant information or miss key information. This paper designs a residual squeeze and excitation attention network (RSEA-Net) to solve the above problems.
Methods
The network has the following main advantages: (1) It can capture richer and more detailed features at different scales in our proposed step convolution module (SCM), which adopts a parallel structure design and has receptive fields of different sizes. (2) This paper also designs a residual squeeze and excitation attention module (RSEAM), which can improve the useful feature gain through space and channel. It can not only eliminate some redundant information but also improve the overall robustness of the model.
Results
This paper verifies the performance of the RSEA-Net in 2D lung CT and tongue image databases. This paper selects seven models for comparison. The experimental results showed that: The RSEA-Net has multi-size respective fields and can eliminate redundant information. In the 2D lung CT database, the Accuracy, Jaccard coefficient, and Dice coefficient reach 0.9939, 0.9705, and 0.9850, respectively. In the tongue image database, the Accuracy, Jaccard coefficient, and the Dice coefficient of the RSEA-Net reach 0.9954, 0.9794, and 0.9895, respectively, which are better than those of the other seven models.
Conclusion
We propose a new deep network model (RSEA-Net). The structure is composed of two U-shaped networks with left and right layers. These are precoding networks and precision segmentation networks. To avoid losing information or producing invalid information caused by frequent convolution and pooling operations, this paper designs an SCM to obtain more multi-scale features. This paper also designed an RSEAM, which can improve the useful feature gain through space and channel, remove some redundant information, and improve the network’s overall robustness. Finally, we also reduced the number of down-sampling operations and simplified the longitudinal complexity. Experimental results show that our method is superior to the original U-Net and other state-of-the-art methods in two different datasets.
Coordinated activation of DNMT3a and TET2 in cancer stem cell-like cells initiates and sustains drug resistance in hepatocellular carcinoma
Authors: Cheng Tao , Zhou Changli , Pang Jiuxia , Tretyakova Natalia , Tse William W. , Liu Yahui , Liu Shujun 
Published: March 2022

Abstract
Background Resistance to targeted therapies represents a major hurdle to successfully treat hepatocellular carcinoma (HCC). While epigenetic abnormalities are critical determinants of HCC relapse and therapeutic resistance, the underlying mechanisms are poorly understood. We aimed to address whether and how dysregulated epigenetic regulators have regulatory and functional communications in establishing and maintaining drug resistance. MethodsHCC resistant cells were characterized by CCK-8, IncuCyte Live-Cell analysis, flow cytometry and wound-healing assays. Target expression was assessed by qPCR and Western blotting. Global and promoter DNA methylation was measured by dotblotting, methylated-DNA immunoprecipitation and enzymatic digestion. Protein interaction, promoter binding and gene mutations of DNMT3a-TET2 was investigated by co-immunoprecipitation, ChIP-qPCR and Sanger sequencing. The regulatory and functional roles of DNMT3a and TET2 were studied by lentivirus infection and puromycin selection. The association of DNMT and TET expression with drug response and survival of HCC patients was assessed by public datasets, spearman correlation coefficients and online tools. Results We identified a coordination of DNMT3a and TET2 as an actionable mechanism of drug resistance in HCC. The faster growth and migration of resistant HCC cells were attributed to DNMT3a and TET2 upregulation followed by increased 5mC and 5hmC production. HCC patients with higher DNMT3a and TET2 had a shorter survival time with less responding to sorafenib therapy than those with lower expression. Cancer stem cell-like cells (CSCs) displayed DNMT3a and TET2 overexpression, which were insensitive to sorafenib. Either genetic or pharmacological suppression of DNMT3a or/and TET2 impaired resistant cell growth and oncosphere formation, and restored sorafenib sensitivity. Mechanistically, DNMT3a did not establish a regulatory circuit with TET2, but formed a complex with TET2 and HDAC2. This complex bound the promoters of oncogenes (i.e., CDK1, CCNA2, RASEF), and upregulated them without involving promoter DNA methylation. In contrast, DNMT3a-TET2 crosstalk silences tumor suppressors (i.e., P15, SOCS2) through a corepressor complex with HDAC2 along with increased DNA methylation in their promoters. Conclusions We demonstrate that DNMT3a and TET2 act coordinately to regulate HCC cell fate in DNA methylation-dependent and -independent manners, representing strong predictors for drug resistance and poor prognosis, and promising therapeutic targets for refractory HCC.
Socio-demographic and morbidity characteristics in people on long-term sick leave
Authors: Oancea Corina , Capraru Simona , Gherman Despina 
Published: March 2022

Abstract
Background. Certifying long-term sick leave along with coordination of the complex rehabilitation programs are important activities of social insurance doctors. They have the role in preventing the loss of work capacity of employees which may lead to leaving the labor market and transition to other social insurance benefits, such as work disability pension.Objectives. Analysis of long term sick leaves (over 183 days) with the identification of risk factors and population groups with low potential for work capacity rehabilitation.Method. We conducted a cross-sectional study between September 2019 and September 2020. The information was collected from the registers of the National Institute of Medical Assessment and Work Capacity Rehabilitation Bucharest and from the EXPMED application. The data were statistically analyzed using the PSPP software. Results. The highest percentage of rehabilitation was achieved in case of traumatic injuries (73.17%), followed by musculoskeletal diseases (70.06%). We noticed lower recovery in case of nervous system diseases (50.56%) and cardiovascular diseases (44.23%). In other pathologies the recovery percentage was 58.37%. People who regained their work capacity were significantly younger than those who turned to other forms of social benefits, disability pension or old-age pension (47.87 ± 8.93 vs. 53.16 ± 8.43).Conclusions. Most of the subjects (72%) regained their work capacity and did not need disability pension. We identified different socio-demographic and morbidity characteristics in people on long term sick leave and target groups that require intensive intervention measures.
Circulation and seasonality of influenza viruses in different transmission zones in Africa from 2013-2019
Authors: Belizaire Marie Roseline Darnycka , N’gattia Anderson Kouabenan , Wassonguema Bibata , Simaleko Marcel Mbeko , Nakoune Emmanuel , Rafaï Clotaire , Lô Baidy , Bolumar Francisco 
Published: March 2022

Abstract
Background: The Influenza Viruses are responsible for more than 5 million of severe cases and 290,000 to 650,000 deaths every year worldwide. Developing countries support 99% of deaths caused by Influenza in children under age of 5. This paper aims to determine the dynamics of influenza viruses in African transmission areas to identify regional seasonality for appropriate decision making and development of regional preparedness and response strategies.Methods: We used data from the FluMart website collected by Influenza national programs for seven periods of transmission (2013-2019). We calculate the weekly proportions of positive influenza cases and follow the trend of the transmission in countries in the Africa continent to determine the seasonality. Results: Over the period, Influenza A(H1N1) pdm 2009, A(H3N2), A(H5N1) viruses, as well as influenza B Victoria and Yamagata lineages identified circulated in the African regions. A(H1N1) pdm 2009 and A(H3N2) were highly circulated in northern and southern Africa. Influenza activity follows an annual and regional variation. In the tropical band, from the easter to the western via the middle, influenza activity is marked by the predominance of A subtypes despite the strong circulation of all B lineages. In the southern and northern Africa, only season has been identified for both regions. In the Eastern, four influenza seasons are differentiated and three for the Western part.Conclusions: The circulating dynamic generates five periods of intense activity during the seasons, so five types of prevention zone. Particularly the tropical band, which is a mixing zone for all influenza viruses, seasons start in the Eastern to end in the Western. Health authorities from countries with same seasons, will need to implement concerted preparedness and control activities.