bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faculty position for full and visiting professor
Authors: Cruz Isabel Cristina Fonseca da 
Published: July 2022

The School of Nursing is seeking candidates for Full Professor in Nursing Administration and Visiting Professor with expertise to complement the majors of the Nursing Practitioner Master Program which are administrative, community, and adult health (gender and ethnicity focus). Candidate should also have a teaching experience and a history of funding an research agenda.Candidates for Full Professor Position contact the University website: www.uff.br To apply for the Visiting Professor position, send your curriculum vitae an a research plan to:Isabel Cristina Fonseca da Cruz, PhD, RN - Program Coordinator Escola de Enfermagem Universidade Federal Fluminense Rua Dr. Celestino, 74 - Niterói 24020-091 - RJ - Brazil
Association of induced sputum eosinophil, absolute eosinophil count and serum immunoglobulin E level in assessment of the clinical severity in bronchial asthma
Authors: Patel Kalpesh , Patel Varun , Gogdani Payal 
Published: July 2022

The study was done with the aim to determine the relationship between the severity of asthma in patient and the level of serum immunoglobulin E, peripheral eosinophil count and nature of sputum.Current research was conducted at the Department of Respiratory Medicine, GAIMS, Bhuj, India over one year. All subjects of Bronchial asthma distinct by Genetic Information Nondiscrimination Act (GINA) guidelines of age 17-61 year were registered. Severity of asthma was assessed by clinical features and by Forced expiratory volume in the first second (FEV1 in spirometry. Following evaluating the sternness of bronchial asthma all subjects undergo sputum examination for sputum eosinophil counts, blood sampling for absolute eosinophil counts and serum IgE levels.Elevated sputum eosinophil count (&#62;3) was significantly elevated in additional subjects with severe persistent asthma even though extra than half of them had normal sputum eosinophil. An important association amid peripheral eosinophil count, sputum eosinophil count, and serum IgE with severe persistent asthma. Mean sputum eosinophil% augments considerably according to severity, demonstrates though affirmative association which was statistically important.The use of inexpensive and easy method with evaluation of AEC, sputum eosinophil count and evaluation of serum IgE level showed a straight measurement of inflammation of airway and allergic etiology of illness.
The Association of Mitochondrial Translocator Protein and Voltage-Dependent Anion Channel-1 in Granulosa Cells with Estradiol Levels and Presence of Immature Follicles in Polycystic Ovary Syndrome
Authors: Mazloomi Sahar , Sanoeei Farimani Marzieh , Tayebinia Heidar , Karimi Jamshid , Amiri Iraj , Abbasi Ebrahim , Khodadadi Iraj 
Published: July 2022

Background: Granulosa cells (GCs) play key roles in oocyte maturation by providing required estradiol (E2). Since the presence of immature oocytes has been reported in cases with polycystic ovary syndrome (PCOS), in this study, the levels of mitochondrial membrane transporter proteins involved in E2 synthesis were determined. E2 concentration and parameters of oxidative status were also measured in follicular fluids of PCOS women.
Methods: Forty-three women with PCOS and 43 healthy women who were candidates for IVF procedure due to their husbands' infertility were enrolled in this case-control study. The gene expression and protein levels of mitochondrial translocator protein (TSPO) and voltage-dependent anion channel 1 (VDAC1) were determined in GCs using RT-qPCR and immunocytochemistry assay, respectively. E2 level was measured with electrochemiluminescence, whereas total cholesterol, total antioxidant capacity (TAC), total oxidant status (TOS), and malondialdehyde (MDA) were determined using colorimetric methods in follicular fluids. Data were analyzed using unpaired t-test or Mann-Whitney U test, and Spearman’s correlation coefficient.
Results: VDAC1 and TSPO were significantly lower in mRNA (p<0.05) and protein levels (p<0.001) of PCOS patients. PCOS patients had lower cholesterol, estradiol, and TAC levels, and higher TOS and MDA contents. E2 level had direct correlation with VDAC1, TSPO, and TAC while it was negatively correlated with TOS, oxidative stress index (OSI), and MDA (p<0.001). Higher E2 levels were associated with higher numbers of high-quality oocytes and conceived embryos (p<0.001).
Conclusion: Decreased E2 levels and increased oxidative stress in the follicular fluid may be the cause of immature oocytes in PCOS cases.
Comparison of Follicular Fluid Paraoxonase 3 Level, Ovarian Hormones and Oocyte Quality between Fertile and Infertile Women
Authors: Janati Sima , Behmanesh Mohammad Amin , Najafzadehvarzi Hosein , Nezami Boshra , Poormoosavi Seyedeh Mahsa 
Published: July 2022

Background: The purpose of the current study was to evaluate the possible effect of follicular fluid paraoxonase 3 (PON 3) on oocyte quality and sex hormones.
Methods: This descriptive-analytical study was performed on totally 90 enrolled women including fifty infertile women presenting with polycystic ovaries and unilateral tubal factor and forty fertile women with male factor infertility referring to Umm-al-Banin Infertility Clinic in Dezful, Iran for in vitro fertilization during October 2018 to November 2019. Oocyte removal was carried out under transvaginal ultrasound guidance, and follicular fluid (FF) was removed and preserved to detect PON3, estrogen, and progesterone levels. In addition, oocyte number and quality were assessed and its association with PON3 activity in the FF was evaluated. One-way ANOVA and Fisher's least significant difference (LSD) were used for data analysis and p≤0.05 were considered statistically significant.
Results: A significant increase was observed in the total number of the oocytes and mature metaphase II oocytes with ≥20 pg/ml of PON3 concentration in the FF (p≤0.05). Moreover, a positive relationship was shown between the increased estradiol level in follicular fluid and PON3, so that the highest estradiol level was observed in the amount of 31-40 pg/ml of PON3 (p≤0.05).
Conclusion: According to the results, as the number of the mature oocytes increased, the amount of PON3 as well as estradiol levels in the FF increased. This research displays an increase in the level of PON3 with mature oocytes, thus supporting the indirect evidence for the function of PON3 in follicle development.
The Importance of High-Resolution Computed Tomography in the Early Diagnosis of Fibrotic Hypersensitivity Pneumonitis
Authors: Kuleshov D. А. , Tyurin I. Е. , Samsonova М. V. , Chernyaev А. L. 
Published: July 2022

Objective: to determine the high-resolution computed tomography (HRCT) signs and their combinations, suggesting the presence of fibrotic hypersensitivity pneumonitis (FHP). Material and methods. The study included 52 patients with pathologically verified diagnosis of FHP who were examined according to the 2021 consensus criteria. All patients had lung HRCT no more than 4 months prior to lung biopsy. The analysis of the changes revealed during HRCT was carried out by qualitative and semi-quantitative methods. The presence of individual signs, the degree of their severity (as percentage relative to the volume of the entire lung tissue) and the features of distribution in the axial and longitudinal planes were taken into account. To search for significant combinations of HRCT signs, a correlation analysis was carried out. Results. The most common HRCT signs in the examined group of FHP patients were reticular changes (96 %) and ground glass opacity (88 %). Most of the patients had signs that did not correspond to the picture of “typical FHP”, such as ground glass and emphysema. Relatively rare cases were centrilobular lesions (46.2 %) and mosaic attenuation (52 %), which are traditionally part of the “typical FHP” picture. In 22 cases (42.3 %) there were signs of emphysema, the presence of which significantly complicated the interpretation of HRCT data even in the cases of characteristic signs of FHP. Correlations of almost all HRCT signs were weak. The most common combinations of features were ground glass + reticular changes, emphysema + honeycombing, reticular changes + bronchiectasis. The combination of ground glass and reticular changes had a moderate correlation, but it has low specificity. Conclusion. The HRCT picture of changes in the lungs among patients with a morphologically verified diagnosis of FHP has important features. A weak correlation between the signs does not allow to identify their combinations that can help in the early diagnosis of FHP with sufficient reliability.
Defining Minimally Important Differences in Functional Outcomes in Musculoskeletal Oncology
Authors: Gazendam Aaron M. , Schneider Patricia , Bhandari Mohit , Busse Jason W. , Ghert Michelle ,   on behalf of the PARITY Investigators
Published: July 2022

Background:
Functional outcomes are commonly reported in studies of patients undergoing limb-salvage surgery for the treatment of musculoskeletal tumors; however, interpretation requires knowledge of the smallest amount of improvement that is important to patients: the minimally important difference (MID). We established the MIDs for the Musculoskeletal Tumor Society Rating Scale-93 (MSTS-93) and Toronto Extremity Salvage Score (TESS) for patients with bone tumors undergoing lower-extremity endoprosthetic reconstruction.

Methods:
This study was a secondary analysis of the recently completed PARITY (Prophylactic Antibiotic Regimens in Tumor Surgery) study. We used MSTS-93 and TESS data from this trial to calculate (1) the anchor-based MIDs with use of an overall function scale and a receiver operating characteristic curve analysis and (2) the distribution-based MIDs based on one-half of the standard deviation of the change scores from baseline to the 12-month follow-up and one-half the standard deviation of baseline scores.

Results:
Five hundred and ninety-one patients were available for analysis. The Pearson correlation coefficients for the association between changes in MSTS-93 and TESS scores and changes in the external anchor scores were 0.71 and 0.57, indicating high and moderate correlations. The anchor-based MID was 12 points for the MSTS-93 and 11 points for the TESS. Distribution-based MIDs were larger: 16 to 17 points for the MSTS-93 and 14 points for the TESS.

Conclusions:
Two methods for determining MIDs for the MSTS-93 and TESS for patients undergoing lower-extremity endoprosthetic reconstruction for musculoskeletal tumors yielded quantitatively different results. We suggest the use of anchor-based MIDs, which are grounded in changes in functional status that are meaningful to patients. These thresholds can facilitate responder analyses and indicate whether significant differences following interventions are clinically important to patients.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Cervical Myelopathy due to Odontoid Fracture Induced by Spinal Involvement of Xanthoma Disseminatum
Authors: Asada Tomoyuki , Koda Masao , Teramura Shin , Sugita Shohei , Matsuoka Ryota , Yamazaki Masashi 
Published: July 2022

Case:
A 47-year-old Japanese woman with a medical history of xanthoma disseminatum (XD) presented with posterior neck pain and abnormal gait without a history of trauma. Imaging studies revealed odontoid process thinning resulting in its fracture due to XD involvement in the atlantoaxial joint and subsequent cervical myelopathy. Posterior C1-C2 fusion surgery improved the patient's symptoms. An XD lesion around the odontoid process was confirmed intraoperatively.

Conclusion:
We report cervical myelopathy caused by XD involvement in the C1-C2 joint, showing that early fusion surgery is critical for treating pathological fractures in patients with XD.
Proximal Thoracic Kyphoscoliosis with Dorsal Myelopathy in a Case of Congenital Absence of Thoracic Pedicles
Authors: Rai Abhishek Kumar , Rathod Tushar Narayan , Mohanty Shubhranshu Shekhar , Hadole Bhushan Sunil , Kolur Shivaprasad Sharangouda 
Published: July 2022

Case:
A 14-year-old boy with proximal thoracic kyphoscoliosis associated with the bilateral absence of thoracic pedicles presented with progressive deformity, paraparesis, and difficulty in ambulation. The case was managed by preoperative halo traction, single-stage 2-level vertebral column resection, decompression, and arthrodesis of thoracic vertebrae. Two years postoperatively, the patient showed neurological improvement, leading to unassisted ambulation and fusion at the corpectomy site.

Conclusion:
Preoperative halo-gravity traction restores the sagittal and coronal balance, improves the functional status of the patient, and corrects the deformity to some extent. 3D printed models help in better understanding of osseous anatomy and minimizing intraoperative time.
Variant Salter-Harris Type III Distal Ulna “T” Fracture in the Setting of Galeazzi Equivalent Wrist Injury
Authors: Puneky George A. , Dickerson Thomas E. , Harimtepathip Peter P. , Bryan Cory A. 
Published: July 2022

Case:
An 11-year-old Caucasian boy presented to the emergency department with a displaced, closed, Galeazzi equivalent (GE) left wrist fracture sustained after a fall. Closed reduction was deemed unsatisfactory because of persistent displacement of the distal ulna epiphysis. An open reduction of the distal ulna and percutaneous fracture pinning was performed. At 1 year, the patient reported return to his preinjury baseline. No evidence of subsequent pathologic growth was detected on follow-up imaging.

Conclusion:
Open anatomic reduction of the distal ulna epiphysis and percutaneous fracture pinning may improve patient outcomes and limit progressive wrist deformity when treating GE wrist injuries.
Group antenatal care: findings from a pilot randomised controlled trial of REACH Pregnancy Circles
Authors: Sawtell Mary , Wiggins Meg , Wiseman Octavia , Mehay Anita , McCourt Christine , Sweeney Lorna , Hatherall Bethan , Ahmad Tahania , Greenberg Lauren , Hunter Rachael , Hamborg Thomas , Eldridge Sandra , Harden Angela 
Published: July 2022

Abstract
Background
Antenatal care has the potential to impact positively on maternal and child outcomes, but traditional models of care in the UK have been shown to have limitations and particularly for those from deprived populations. Group antenatal care is an alternative model to traditional individual care. It combines conventional aspects of antenatal assessment with group discussion and support. Delivery of group antenatal care has been shown to be successful in various countries; there is now a need for a formal trial in the UK.
Method
The study aimed to explore optimum methods for testing the effectiveness of a model of group care (Pregnancy Circles) in NHS-settings serving populations with high levels of deprivation and diversity. An individual randomised controlled trial (RCT) was conducted in an inner London NHS trust as an external pilot for a potential fully-powered RCT with integral economic evaluation. Inclusion criteria included: pregnant with due date in a certain range, 16 + years and living within specified geographic areas. Data were analysed for completeness and usability in a full trial; no hypothesis testing for between group differences in outcome measures was undertaken. Pre-specified progression criteria corresponding to five feasibility measures were set. Additional aims were to assess the utility of our proposed outcome measures and different data collection routes. A process evaluation utilising interviews and observations was conducted.
Results
Seventy-four participants were randomised; two more than the a priori target. Three Pregnancy Circles of eight sessions each were run. Interviews were undertaken with ten participants, seven midwives and four other stakeholders; two observations of intervention sessions were conducted. Progression criteria were met at sufficient levels for all five measures: available recruitment numbers, recruitment rate, intervention uptake and retention, questionnaire completion rates. Outcome measure assessments showed feasibility and sufficient completion rates; development of an economic evaluation composite measure of a ‘positive healthy birth’ was initiated.
Conclusion
Our pilot findings indicate that a full RCT would be feasible to conduct, with a few adjustments related to recruitment processes, language support, accessibility of intervention premises and outcome assessment.
Trial Registration
ISRCTN ISRCTN66925258. Retrospectively registered, 03 April 2017.
Neurotoxic effects of different sizes of plastics (Nano, Micro, and Macro) on juvenile common carp (Cyprinus carpio)
Authors: Hamed Mohamed , Martyniuk Christopher J. , Naguib Mervat , Lee Jae-Seong , Sayed Alaa El-Din H. 
Published: July 2022

Abstract
Using common carp as a model, we assessed the effects of polyethylene (PE) plastics on brain. We measured activity of acetylcholinesterase (AChE), monoamine oxidase (MAO), and the content of nitric oxide (NO) in carp brain following exposure to 100 mg/L of either macroplastics (MaP), microplastics (MPs) or nanoplastic (NPs) for 15 days compared to an unexposed group. Following exposure, each biochemical biomarker was reduced 30–40%, with a higher magnitude of change corresponding to the smaller size of the particles (NPs > MPs > MaPs). In the carp tectum, exposure for 15 days to plastic particles caused varying degrees of necrosis, fibrosis, changes in blood capillaries, tissue detachment, edema, degenerated connective tissues, and necrosis in large cerebellar neurons and ganglion cells. In the carp retina, there was evidence for necrosis, degeneration, vacuolation, and curvature in the inner layer. Here we provide evidence that exposure to plastic particles can be associated with neurotoxicity in common carp.
Controlling cellulose feedstock size allows for modification of cellulose-based carbon-based solid acid size
Authors: Qu Zheng , Han Ying , Ma Zihao , Wang Qingyu , Wang Xing , Li Yao , Sun Guangwei 
Published: July 2022

Abstract
Carbon-based solid acids (CSA) have grown in popularity in recent years owing to their strong catalytic activity, thermal stability, and reusability. The size effect has a significant influence on the catalytic activity of carbon-based solid acids in heterogeneous catalysts. The impacts of raw material size on the shape, sulfonation degree, and catalytic activity of produced carbon-based solid acids were examined in this article. Various sizes of microcrystalline cellulose (MCC), cellulose nanocrystals (CNC), and cotton fibers (CP) were used as carbon sources in a simple carbon-sulphonation method to synthesize carbon-based solid acids. The produced CAS has a high concentration of sulphonic acid groups, as well as hydroxyl and carboxyl groups, and exhibits remarkable catalytic activity for the conversion of xylan to xylose. The solid acids generated from MCC have the most homogeneous shape, the greatest degree of sulphonation, and the highest catalytic activity. The conversion rate of xylan hydrolysis to xylose was up to 58.8% under ideal reaction conditions (150°C, 4h), and the catalyst retained almost its initial level of activity after five cycles with no appreciable deactivation.
On a New Human-Based Metaheuristic Optimization Algorithm Based on Imitating Foreign Language Education Process
Authors: Trojovský Pavel , Dehghani Mohammad , Trojovská Eva , Milkova Eva 
Published: July 2022

Abstract
The paper presents a new human-based metaheuristic algorithm called Language Education Optimization (LEO). LEO is inspired by the foreign language education process in which a language teacher trains the students of language schools in the desired language skills and rules. LEO is mathematically modeled in three phases: (i) students selecting their teacher, (ii) students learning from each other, and (iii) individual practice, considering exploration in local search and exploitation in local search. The performance of LEO in optimization tasks has been challenged against twenty-three benchmark functions of a variety of unimodal and multimodal types. The optimization results show that LEO, with its acceptable ability to explore, exploit, and maintain a balance between them, has efficient performance in optimization applications and in solution presentation. LEO efficiency in optimization tasks is compared with ten well-known metaheuristic algorithms. Analyses of the simulation results show that LEO has effective performance in dealing with optimization tasks and is significantly superior and more competitive in combating the compared algorithms.
Efficacy and Safety of Bone Management Agents Administered at 12 Weeks vs. 4 Weeks in Patients with Bone Metastases: A Systematic Review
Authors: Sato Junya , Kodaira Makoto , Harada Hiroyuki , Iguchi Haruo , Yoshida Taichi , Shibata Hiroyuki 
Published: July 2022

Abstract
Background: Bone Modifying Agents (BMAs) have been used to prevent skeletal-related events (SRE) in cancer patients with bone metastases. In this meta-analysis, efficacy and adverse events (AEs) were studied based on a de-escalation strategy in which the BMA dosing interval was prolonged from 4 to 12 weeks.Methods: PubMed, Cochrane, ICHUSHI, and CINAHL were searched for articles on BMA dosing intervals from outcomes measured were the incidence of SRE and related various AEs. A quantitative meta-analysis was performed using a random-effects model to calculate relative risk ratios (RR) and 95% confidence intervals (CI).Result: The meta-analysis included three randomized controlled studies (RCTs) of Zoledronic acid hydrate (ZA) (n = 2,663) and six RCTs (n = 141) on BMA other than zoledronic acid. There was no difference in the incidence of SREs when comparing dosing frequency of 12 versus 4 weeks for BMA (RR = 1.21, 95% CI [0.82-1.78], p = 0.33). Further, AEs related to treatment discontinuation were significantly less frequent with ZA given every 12 weeks than when given every 4 weeks (RR = 0.51 [0.30-0.89], p = 0.02). In particular, renal dysfunction leading to grade ≥3 or discontinuation of treatment with ZA occurred significantly less frequently with every 12-week dosing (RR = 0.33 [0.12-0.91], p = 0.33). Conclusion: The meta-analysis showed no influence of BMA de-escalation on the incidence of SRE, nevertheless, AEs appeared to reduce with the usage of ZA.
Dietary Oregano aqueous extract improves intestinal health of broilers through modulating gut microbial populations
Authors: Zhang Fan , Yang Jiantao , Li Yanhe , Zhan Qinyi , Li Yingge , Yang Xiaojun 
Published: July 2022

Abstract
Background: Intestinal health plays an important role in broiler chicken production. Oregano aqueous extract (OAE) effectively exerts anti-inflammatory and antibacterial effects. However, the protective effects of OAE on gut health in broilers and the underlying mechanism remain unclear. This study aimed to investigate the potential effects of OAE on production performance, the intestinal microbiome and gut health, and to verify the effect of intestinal microbe on gut health. Results: Dietary 700 mg/kg OAE supplementation resulted in an increase (P < 0.05) in body weight and a decrease (P < 0.05) in feed conversion ratio than the control at D42 of the trial. Compared to the control, OAE addition resulted in lower (P < 0.05) jejunal crypt depth and the relative mRNA expression of IL-4 and IL-10 at D42. Dietary OAE increased (P < 0.05) the abundance of Firmicutes and Lactobacillus in the cecum, and affected the content of short-chain fatty acids. In addition, the results of microorganisms affected by OAE in vitro were consistent with those in vivo. The relative mRNA expression of IL-4 was significantly increased (P < 0.05) by feeding oregano fermentation microorganisms at D42. And the secretion of SIgA was significantly increased (P < 0.05) in the ileum in S group.Conclusions: Dietary OAE addition could increase the abundance of intestinal Lactobacillus and acetic acid content, which were capable to improve intestinal mucosal immunity and barrier function, thus maintaining intestinal health and improving production performance.