bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast Training of a Transformer for Global Multi-horizon Time Series Forecasting on Tensor Processing Units
Authors: García-Nava J. Luis , Flores Juan J. , Tellez Victor M. , Calderon Felix 
Published: August 2022

Abstract
Time Series Forecasting (TSF) is essential to key domains, and the transformer neural network has advanced the state-of-the-art on global, multi-horizon TSF benchmarks. The quadratic time and memory complexity of the vanilla transformer (VT) hinders its application to big data environments; therefore, multiple efficient variants of the VT that lower complexity via sparse self-attention have been proposed. However, less complex algorithms do not directly produce faster executions, and machine learning models for big data are typically trained on accelerators designed for dense-matrix computation that render slower performance with sparse matrices. To better compare the accuracy-speed trade-off of the VT and its variants, it is essential to test them on such accelerators. We implemented a cloud-based VT on Tensor Processing Units to address this task. Experiments on large-scale datasets show that our transformer outperforms two reference models on accuracy while reducing training times from hours to under two minutes.
Testosterone is associated with abdominal body composition derived from computed tomography: A large cross sectional study
Authors: Han Seungbong , Jeon Young-Jee , Lee Tae Young , Park Gyung-Min , Park Sungchan , Kim Seong Cheol 
Published: August 2022

Abstract
To evaluate the association between serum testosterone and abdominal body composition based on abdominopelvic computed tomography (APCT) measurements after adjusting for individual metabolic syndrome components. We performed a cross-sectional study using subjects who underwent a general health examination with abdominopelvic computed tomography and testosterone measurements. Body composition was evaluated with APCT. To confirm an association between testosterone and abdominal body composition, we conducted linear regression analysis. The effect of abdominal body composition was adjusted for important clinical factors such as age, albumin, and metabolic components in the multivariable regression analysis. Overall, 1,453 subjects were included in the primary analysis. After adjustment for age, individual metabolic components, albumin, hemoglobin A1c, and C-reactive protein, we found that subcutaneous fat area index (β = -0.042, p<0.001), total abdominal muscle area index (β = 0.115, p<0.001), normal attenuation muscle area index (β = 0.070, p<0.001), and loge-transformed lower attenuation muscle area index (β = 0.140, p=0.002) had an association with loge-transformed testosterone level. After adjusting for individual metabolic syndrome components, testosterone was significantly associated with subcutaneous fat, but not visceral fat. In addition, testosterone was positively correlated with abdominal muscle regardless of qualitative features such as fat-rich and fat-free.
An assessment of the integrated multi-criteria and new models efficiency in watershed flood mapping
Authors: Solaimani karim , Shokrian Fatemeh , Darvishi shadman 
Published: August 2022

Abstract
Nowadays, with significant climate change, the trend of environmental hazards is increasing. In the meantime, floods have shown a growing trend than other hazards. Haraz watershed in northern Iran is prone to floods due to the heavy rainfall with irregular pattern. Therefore, combining different methods and examining new approaches is an essential step in the development of methods in this field. In the present study, Analytical Network Process, Analytic Hierarchy Process and Fuzzy Analytic Hierarchy Process models were combined with Ordered Weighted Average, Weighted Linear Combination, Local Weighted Linear Combination models to prepare a flood risk map. The performance of two new models, Weighted Multi-Criteria Analysis and Geo-Technique for Order of Preference by Similarity to Ideal Solution, was also evaluated in this field. The results of the models showed that in general the basin is in a moderate risk situation. Meanwhile, the south-eastern parts of the basin show a high flood risk situation. Also, by comparing the models, it was found that the combination of multi-criteria models and the use of Weighted Multi-Criteria Analysis and Geo-Technique for Order of Preference by Similarity to Ideal Solution models are very effective and efficient for preparing flood risk maps.
Photocatalytic oxidation of benzene to phenol and dye over N and S doped ferromagnetic nanosize TiO2
Authors: Shete Madhavi , Fernandes Julio 
Published: August 2022

Abstract
In the present investigation we report presence of N, S and Ti3+ in the TiO2 samples and surface exhibits acidic characteristics. Synthesized TiO2 samples were also found to be ferromagnetic in nature at room temperature and shows high photocatalytic activity in comparison to commercially available TiO2 (DP-25). Nanosize TiO2 with high surface area was obtained by simple sol – gel method of synthesis and during the synthesis hydrazine sulphate was used as fuel. Synthesized TiO2 was found to be with N and S doping and also surface defects were present due to cationic and anionic vacancies. The presence of defects were confirmed from the Raman, IR, SEM-EDAX, PL analysis. Presence of Ti3+ in the TiO2 samples was confirmed from the ESR and XPS Spectra. XPS also showed presence of nitrogen and sulphur doping in the TiO2 samples. Synthesized TiO2 possesses acidic surface and surface acidity was measured from the pyridine adsorption and NH3-TPD studies. Ferromagnetic behavior of the synthesized samples was confirmed from the VSM measurements. Synthesized samples were further studied for their photocatalytic activity towards methylene blue dye and 4-nitrophenol degradation and for photo-oxidation benmezene to phenol conversion.
Dysregulated neuronal autophagy pathway in dorsolateral prefrontal cortex of elderly schizophrenia patients
Authors: Kim Pitna , Patel Saloni , Pruett Brandon , Meador-Woodruff James H. 
Published: August 2022

Abstract
Schizophrenia (SCZ) is a chronic psychiatric disorder that is associated with neuronal dysfunction. Recently, the autophagy pathway in the brain has become a target of investigation in this illness. Autophagy is a homeostatic process that serves as an intracellular quality control mechanism and a recycling pathway. It is activated under stress to prevent the accumulation of abnormal or dysfunctional cellular components including macromolecules such as proteins, nucleic acids, and biomolecular complexes, and to facilitate protein recycling. Autophagy is a tightly regulated cellular process orchestrated by protein complexes. The initiation of autophagy is mediated by the ULK1 and VPS34 complexes. Initiation of autophagosome formation is regulated by the ULK1 complex, which contains the serine/threonine protein kinase ULK1 and its essential protein partners FIP200, ATG13 and ATG101. Upon activation, the ULK1 complex regulates the phosphorylation and activation of another kinase complex containing VPS34, the class III phosphatidylinositol 3-kinase, and its binding partners VPS15, BECLIN1 and ATG14L. In this study, we measured the expression of key regulatory proteins involved in these neuronal autophagy initiation complexes in postmortem dorsolateral prefrontal cortex of 22 pairs of SCZ and matched comparison subjects by Western blot analysis. Additionally, we measured two proteins, LC3BII and p62, that play a role in the formation of the autophagosome. In SCZ, we found decreased ULK1 expression (23%), increased p62 expression (25%), decreased p62 phosphorylation at serine 403 (27%), but no changes in VPS34 or LC3BII expression. Using co-immunoprecipitation with LC3BII, we found a 56% reduction of LC3BII–p62 interaction in SCZ. Additionally, we found increased p62-positive aggregates in SCZ brain. These findings suggest dysregulation of the formation of the autophagosome and dysfunction of the neuronal autophagy pathway in SCZ brain.
The Fundamental Theorem for Locally Projective Geometries
Authors: de Salas Juan Bautista Sancho 
Published: August 2022

Abstract
We deal with generalizations of the Fundamental Theorem of Projective Geometry to other related geometries (of dimension ≥ 3) and non bijective maps. We consider locally projective geometries and locally affino-projective geometries (which include the classical Möbius, Laguerre and Minkowski geometries).MSC 2020: 51A45, 51A10
Electrocorticographic activation patterns during electroencephalographic microstates
Authors: Mikutta Christian A. , Knight Robert T. , Sammler Daniela , Müller Thomas J. , Koenig Thomas 
Published: August 2022

Abstract
Introduction:
Electroencephalography (EEG) microstates are successive short time periods of stable scalp field potentials that represent spontaneous activation of brain resting-state networks. EEG microstates are assumed to mediate local activity patterns. To assess this hypothesis, we correlated momentary EEG microstate dynamics with the temporo-spectral evolution of electrocorticography (ECoG) and stereotactic EEG(SEEG) depth electrode recordings.
Methods
We analyzed resting-state data (5 min) from two participants with simultaneous noninvasive scalp EEG and invasive ECoG, and SEEG recordings. Data were recorded during the presurgical evaluation of pharmacoresistant epilepsusing subdural and intracranial electrodes. After standard preprocessing, we fitted microstate template maps to the scalp EEG data. Using covariance mapping with EEG microstate timelines and ECoG/SEEG temporo-spectral evolutions as input, we identified systematic changes in the activation of ECoG/SEEG local field potentials in different frequency bands (theta, alpha, beta, and high gamma) depending on the presence of a particular microstate class.
Results
We found a significant covariation of ECoG/SEEG spectral amplitudes with microstate timelines in all four frequency bands (p = .001, permutation test). The covariance patterns of the ECoG/SEEG electrodes during different microstates were similar for the two observed participants.
Discussion
To our knowledge, this is the first study to demonstrate distinct activation/deactivation patterns of frequency-domain ECoG local field potentials associated with simultaneously present EEG microstates.
Safety and efficacy of immune checkpoint inhibitors in patients with cancer and viral hepatitis: The MD Anderson Cancer Center experience
Authors: Nardo Mirella , Yilmaz Bulent , Nelson Blessie Elizabeth , Torres Harrys A. , Wang Lan Sun , Granwehr Bruno Palma , Song Juhee , Pria Hanna Rafaela Ferreira Dalla , Trinh Van A. , Oliva Isabella C. Glitza , Patel Sapna P. , Tannir Nizar M. , Kaseb Ahmed Omar , Altan Mehmet , Lee Sunyoung , Miller Ethan , Zhang Hao Chi , Stephen Bettzy A. , Naing Aung 
Published: August 2022

Abstract
Background: Despite the clinical benefit with Immune checkpoint inhibitors (ICIs), patients with a viral hepatitis have been excluded from clinical trials because of safety concerns. The purpose of this study was to determine the incidence rate of adverse events (AEs) in patients with viral hepatitis who received ICIs for cancer treatment.Materials and methods: We conducted a retrospective study in patients with cancer and concurrent hepatitis B or C, who had undergone treatment with ICI at MD Anderson Cancer Center from January 1, 2010 to December 31, 2019.Results: Of the 1076 patients screened, we identified 33 with concurrent hepatitis. All 10 patients with HBV underwent concomitant antiviral therapy during ICI treatment. Sixteen of the 23 patients with HCV received it before the initiation of ICI. The median follow-up time was 33 months (95% CI, 23-45) and the median duration of ICI therapy was 3 months (IQR, 1.9-6.6). Of the 33 patients, 12 (39%) experienced irAEs (immune-related adverse events) of any grade, with 2 (6%) having grade 3 or higher. None of the patients developed hepatitis toxicities.Conclusion: ICIs may be a therapeutic option with an acceptable safety profile in patients with cancer and advanced liver disease.
Atorvastatin Improves Cisplatin Sensitivity Through Modulation of Cholesteryl Ester Homeostasis in Breast Cancer Cells
Authors: Santos Diandra Zipinotti dos , Guimaraes Isabella dos Santos , Hakeem-Sanni Mariam , Cochran Blake , Rye Kerry-Anne , Grewal Thomas , Hoy Andrew , Rangel Leticia 
Published: August 2022

Abstract
Background: Acquired treatment resistance is a major problem in breast cancer management. Alterations in lipid metabolism have been proposed to contribute to tumor progression and the development of drug resistance. The present study aimed to identify the role of cholesteryl ester (CE) metabolism in MCF-7 and MDA-MB-231 breast cancer cell line response to cisplatin (CDDP) treatment in the acute setting. Methods: MCF-7 (luminal A), MDA-MB-231 (triple-negative) and CDDP-resistant MDA-MB-231 (MDACR) cell lines were grown in the presence or absence of CDDP in combination with atorvastatin (ATV), lipid depletion or low-density lipoprotein (LDL) loading and were analyzed by a variety of biochemical and radiometric techniques. Results: Co-administration of CDDP and ATV strongly reduced cell proliferation and viability to a greater extent than CDDP alone, especially in MDA-MB-231 cells. These findings were associated with reduced CE synthesis and storage in MDA-MB-231 cells. In MDACR cells, acetyl-CoA acetyltransferase 1 (ACAT-1) was upregulated compared to naïve MDA-MB-231 cells and ATV treatment restored CDDP sensitivity, suggesting that aberrant ACAT-1 expression contributes to CDDP resistance in TNBC cells. Conclusions: These findings indicate that the elevated susceptibility of MDA-MB-231 cells to co-administration of CDDP and ATV, is associated with an increased reliance on CE availability. Our data from these cell culture-based studies supports the upregulation of cholesterol homeostasis as an adaptive response that contributes to aggressiveness and chemotherapy resistance.
Micrrosus cirrosus SZ 2021: A potentially new genotype of Micrrosus cirrosus, which can cause fatal pulmonary infection in acute leukemia patients after haplo-HSCT
Authors: Cheng Jianjun , Zeng Daxiong , Zhang Ting , Zhang Lu , Han Xiu , Zhou Peng , Wang Lin , He Jun , Han Qingzhen 
Published: August 2022

Abstract
Background
Uncommon Microascus cirrosus (M.cirrosus) species have been reported to cause growing subcutaneous and invasive fungal infections worldwide. To our knowledge, no comprehensive clinical characteristics and etiological identification in laboratory tests have been defined till now, notably, for fatal pulmonary infections in the crowd of patients undergoing hematopoietic stem cell transplantation (HSCT).
Methods
We studied the pulmonary infection due to a new M.cirrosus, analyzed other related cases retrospectively in our hospital and reviewed other reported cases. This isolated M.cirrosus was cultured and determined by morphological observation, antifungal susceptibility, multi-locus sequence analysis (MLST), whole genome sequencing, metagenomic next-generation sequencing(mNGS), and other analysis.
Results
This isolated M.cirrosus named M. cirrosus SZ 2021 was resistant to various therapies and accounted for the fatal pulmonary infection in the HSCT patient. Notably, M.cirrosus could be confirmed by mNGS in another two lung infections of HSCT patients. For this new isolated fungus, it had short chains of conidia without apical cysts for the Micrrosus genus, whereas growing faster and bigger on chocolate agar plate than Sabouraud’s agar. Furthermore, it was not sensitive to fluconazole, amphotericin B, 5-flucytosine, caspofungin and other drugs by drug sensitivity test in vitro, supporting its bad prognosis and a sharp increased colonies across the half month process of insufficient antifungal treatment. This isolate had not been correctly identified until the whole genome sequencing by NGS and MLST were finished, because of the poor knowledge of gene information on the genus. The whole nucleotide sequence (2.693 billion bases) of the genome from M. cirrosus SZ 2021 have been uploaded in NCBI database for the first time. In addition, its protein fingerprint has been presented by MALDI-TOF-MS.
Conclusions
M. cirrosus SZ 2021 is a potentially new genotype of M.cirrosus, which can cause fatal pulmonary infection in immunocompromised patients. These established complete laboratory tests facilitate its correct and rapid etiological diagnosis, especially for the culture independent rapid detection by mNGS.
Physicochemical characterization of texture-modified pumpkin by vacuum enzyme impregnation: Textural, chemical and image analysis
Authors: Hernández Sergio , Gallego Marta , Verdú Samuel , Barat José M. , Talens Pau , Grau Raúl 
Published: August 2022

Abstract
Texture-modified pumpkin was developed by using vacuum enzyme impregnation to soften texture to tolerable limits for the elderly population with swallowing and chewing difficulties. The impregnation process, and macrostructural and microstructural enzyme action, were explored by the laser light backscattering imaging technique and a microscopic study by digital image analysis. Texture was analyzed by a compression assay. The effect of enzyme treatment on antioxidant capacity and sugar content was evaluated and compared to the traditional cooking effect. Image analysis data demonstrated the effectiveness of the impregnation process and enzyme action on plant cell walls. Enzyme-treated samples at the end of the process had lower stiffness values with no fracture point, significantly greater antioxidant capacity and significantly lower total and reducing sugars contents than traditionally cooked pumpkins. The results herein obtained demonstrate the capability of using vacuum impregnation treatment with enzymes to soften pumpkins and their positive effects on antioxidant capacity and sugar content to develop safe and sensory-accepted texture-modified products for specific elderly populations.
Torque Control Based Induction Motor Speed Control Using Anticipating Power Impulse Technique
Authors: Karupusamy Sathishkumar , Kalnoor Gauri , Kumar Anil 
Published: August 2022

Abstract
In this model the induction motor speed controlis based on torque control drive is analysis the output power using Anticipating Power Impulse Technique (APIT). Induction motors are used in various applications, this is a model of a motor used in constant speed applications. Vibrations and singularities are eliminated with the sliding mode control of conventional terminals. In this method, the reference state is determined in a systematic manner so that the maximum torque per ampere and flux limiting operation and the reference torque tracking can be determined. The difficulty of a controller driver is choosing a switch with the proper control scheme to achieve dynamic and steady state response speed requirements and the proposed method is completely varied from conventional model. AnAnticipating Power Impulse Technique (APIT)is the proposed systemto the induction motor drive is control it is also applied to be speed control of the motor. The system presented here analyses motor current and rotor position, which helps to obtain a suitable switching pulse diver circuit. Because of low switching loss speed control. In this system, MATLAB software is used to develop control circuit simulations. It is expected that the simulation output will reduce the torque ripple verified by experiments and Anticipating Power Impulse Technique(APIT), giving the system output excellent stability.
Twice evasions of Omicron variants explain the temporal patterns in six Asia and Oceania countries
Authors: Chen Boqiang , Zhao Yanji , Jin Zhen , He Daihai , Li Huaichen 
Published: August 2022

Abstract
Background: The ongoing Coronavirus 2019 (COVID-19) pandemic has emerged and caused multiple pandemic waves in the following six countries: India, Indonesia, Nepal, Malaysia, Bangladesh and Myanmar. Some of the countries had been much less studied in this devastating pandemic. This study aims to assess the impact of Omicron variant in these six countries and estimate the infection fatality rate (IFR) and the transmission rate β(t) in the unit of basic reproduction number R 0 (t) in these six South Asia, Southeast Asia and Oceania countries.Method: We propose a Susceptible-Vaccinated-Exposed-Infectious-Hospitalized-Death-Recovered model with a time-varying transmission rate to fit the multiple waves of COVID-19 pandemic in the aforementioned six countries. The level of immune evasion and the intrinsic transmissibility advantage of Omicron variant is also estimated in this model.Results: We fit our model to the reported cases well. We estimate the IFR (in the range of 0.016% to 0.136%) and the transmission rate β(t) in the unit of basic reproduction number R 0 (t) (in the range of 0 to 9) in the six countries. The multiple pandemic waves in each country are observed in our simulation results.Conclusions: The invasion of Omicron variant caused the new pandemic waves in the six countries. The higher R 0 (t) suggests the intrinsic transmissibility advantage of Omicron variant. Our model simulation forecast implies that the Omicron pandemic wave may be mitigated due to the increasing immunized population and the vaccine coverage.
Uniform expansion vs. non-uniform expansion of gross tumor volume based on recurrence patterns to form planning target volume of stereotactic body radiation therapy for locally advanced pancreatic cancer: protocol of a randomized phase II study
Authors: Jiang Lingong , Zhu Xiaofei , Yu Haiyan , Zhao Xianzhi , Ye Yusheng , Cao Yangsen , Ju Xiaoping , Cao Fei , Zhang Huojun 
Published: August 2022

Abstract
• Background: There is no guideline or consensus on target delineations of stereotactic body radiation therapy (SBRT) for locally advanced pancreatic cancer (LAPC). Two different modes of target delineation are compared to identify a superior one beneficial for improvement of outcomes.• Methods: The study is a single-center, randomized phase II trial. Patients are randomly allocated to two groups with different delineations of planning target volume (PTV) of SBRT followed by a same chemotherapy regimen. Patients in Arm A receive uniform expansions of gross tumor volume (GTV) to form PTV, while PTV is contoured by non-uniform expansions of GTV based on recurrence patterns in Arm B. The primary endpoint is 1-year local control rate (1y-LC), and the secondary endpoints are disease progression-free survival (PFS), overall survival (OS), and treatment-related toxicity. Radiotherapy-induced adverse events (AEs) are recorded according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer (RTOG/EORTC), and chemotherapy AEs are graded according to Common Terminology Criteria for Adverse Events version 5.0 (CTCAE 5.0). This trial protocol has been approved by the Ethics committee of Changhai hospital. The ethics number is CHEC2020-099.• Discussion: Empirical uniform expansions of GTV is commonly practiced in most centers for delineations of PTV. However, limited evidence has confirmed potential benefits of this method. Therefore, we designed this prospective phase II study to investigate the hypothesis that better outcomes are found in the proposed method in our previous study than that used now.• Trial registration: Registration number: NCT04699539. Date of registration: 07 January, 2021.
Highly efficient current-driven magnetic octupole domain-wall dynamics
Authors: Wu Mingxing , Chen Taishi , Nomoto Takuya , Isshiki Hironari , Nakatani Yoshinobu , Higo Tomoya , Tomita Takahiro , Kondou Kouta , Arita Ryotaro , Nakatsuji Satoru , Otani YoshiChika 
Published: August 2022

Abstract
The authors have requested that this preprint be removed from Research Square.