bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histoire, littérature grise, littérature : les prospectus de Lancelot Voisin de La Popelinière et de Philippe Artières (XVI e /XXI e siècles)
Authors: Chassain Adrien 
Published: August 2022

Dédié au genre du prospectus auctorial dans le contexte du discours de l’histoire, cet article place en regard Le Dessein de l’histoire nouvelle des François (1599) de Lancelot Voisin de La Popelinière et Rêves d’histoire (2006/2014) de Philippe Artières. En 1599 comme en 2006, l’écriture du projet relève d’une forme de « littérature grise » couramment mise à profit par les historiens afin d’obtenir divers soutiens symboliques et financiers auprès de mécènes ou d’institutions publiques. L’article étudie et historicise différents modes de textualisation pouvant affecter cette forme prospective, dès lors qu’elle est soumise à un geste de publication.
La psychose et la métaphore
Authors: Dellanoce Filippo , Abdelouahed Houria 
Published: August 2022

Dans le Séminaire III consacré à l’étude des psychoses, Lacan dit de Schreber qu’il est certes un écrivain, mais pas un poète. Le délire de Schreber et, par extension, la psychose, sont essentiellement caractérisés par un manque de métaphore. Dans notre contribution, nous examinerons d’abord la littérature psychanalytique et psychiatrique concernant le diagnostic de la psychose de Schreber, puis nous analyserons la thèse de la forclusion du signifiant Nom-du-Père comme cause de la psychose. Pour comprendre la fonction métaphorique du signifiant, nous examinons ensuite la nature linguistique de la métaphore, sur la base des théories d’Aristote et de U. Eco. La métaphore est un instrument de connaissance cognitive et additive : par la métaphore, nous atteignons une nouvelle connaissance, et la métaphore apporte la connaissance en dessinant par le langage une nouvelle caractéristique du fonctionnement de la réalité. Une fois que la première métaphore, celle paternelle, est absente, c’est la métaphore comme fonction de connaissance additive qui manque. Par conséquent, aucune autre métaphore ne sera possible, puisque le sujet n’a pas rencontré la possibilité pour une nouvelle signification d’apparaître, celle-ci apportée par le travail du métaphorique. Nous proposons enfin quelques considérations conclusives sur le langage psychotique, ainsi qu’une nouvelle articulation entre métaphore, doute et certitude délirante.
Fucoxanthin suppresses OxLDL-induced inflammation via activation of Nrf2 and inhibition of NF-κB signaling
Authors: Rajendran Peramaiyan , AlZahrani Abdullah M 
Published: August 2022

Objective:
To explore the impact of fucoxanthin on oxidized low-density lipoprotein (OxLDL)-induced stress and inflammation in human endothelial cells and its underlying mechanisms.

Methods:
HUVECs were treated with OxLDL and/or fucoxanthin for a range of time points and concentrations. We evaluated the effects of fucoxanthin on OxLDL-induced HUVECs using the MTT assay, reactive oxygen species accumulation assay, ELISA, RT-PCR, immunofluorescence, and Western blotting.

Results:
Fucoxanthin enhanced the cell viability in a dose dependent manner after OxLDL exposure. Furthermore, fucoxanthin pretreatment significantly decreased OxLDL-induced reactive oxygen species production and prevented the activation of the nuclear factor kappa-B pathway, which led to substantial suppression of pro-inflammatory gene expressions. OxLDL-induced upregulation of interleukin-6, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, interleukin-1β, monocyte chemotactic protein-1, cyclooxygenase-1, and tumor necrosis factor-α was significantly reduced by fucoxanthin.

Conclusions:
Fucoxanthin can inhibit OxLDL-induced vascular inflammation and oxidative stress in HUVECs by targeting Nrf2 signaling pathways.
Naringin attenuates oxidative stress, inflammation, apoptosis, and oxidative DNA damage in acrylamide-induced nephrotoxicity in rats
Authors: Gelen Volkan , Yıldırım Serkan , Şengül Emin , Çınar Ali , Çelebi Fikret , Küçükkalem Merve , Gök Melahat 
Published: August 2022

Objective:
To explore the possible effects of naringin on acrylamide-induced nephrotoxicity in rats.

Methods:
Sprague-Dawley rats weighing 200-250 g were randomly divided into five groups. The control group was given intragastric (i.g.) saline (1 mL) for 10 d. The acrylamide group was given i.g. acrylamide in saline (38.27 mg/kg titrated to 1 mL) for 10 d. The treatment groups were administered with naringin in saline (50 and 100 mg/kg, respectively) for 10 d and given i.g. acrylamide (38.27 mg/kg) 1 h after naringin injection. The naringin group was given i.g. naringin (100 mg/kg) alone for 10 d. On day 11, intracardiac blood samples were obtained from the rats when they were under anesthesia, after which they were euthanized. Urea and creatinine concentrations of blood serum samples were analyzed with an autoanalyzer. Enzyme-linked immunosorbent assay was used to quantify malondialdehyde, superoxide dismutase, glutathione, glutathione peroxidase, catalase, tumor necrosis factor-β, nuclear factor-κB, interleukin (IL)-33, IL-6, IL-1β, cyclooxygenase-2, kidney injury molecule-1, mitogen-activated protein kinase-1, and caspase-3 in kidney tissues. Renal tissues were also evaluated by histopathological and immunohistochemical examinations for 8-OHdG and Bcl-2.

Results:
Naringin attenuated acrylamide-induced nephrotoxicity by significantly decreasing serum urea and creatinine levels. Naringin increased superoxide dismutase, glutathione, glutathione peroxidase, and catalase activities and decreased malondialdehyde levels in kidney tissues. In addition, naringin reduced the levels of inflammatory and apoptotic parameters in kidney tissues. The histopathological assay showed that acrylamide caused histopathological changes and DNA damage, which were ameliorated by naringin.

Conclusions:
Naringin attenuated inflammation, apoptosis, oxidative stress, and oxidative DNA damage in acrylamide-induced nephrotoxicity in rats.
The acute effect of systemic blood pressure reduction on intraocular pressure in hypertensive patients
Authors: Tiambeng Canan , Batur Ali , Dikmetas Özlem , Aksu Nalan Metin 
Published: August 2022

OBJECTIVES:
Previous studies have shown an association between systemic hypertension and intraocular pressure (IOP). We analyzed the relationship between the decreases of the blood pressure (BP) and IOP in hypertensive patients.

METHODS:
The study includes a total of 214 patients: 158 hypertensive and 56 normotensive patients as study and control groups, respectively. The IOP of each eye in both the groups was measured once with a noncontact tonometer at presentation and an hour after BP reduction to normal in the study group. We analyzed the reduction in IOP with decreasing BP.

RESULTS:
In the study group, the mean IOP was 15.29 ± 4.05 mmHg in the right and 15.11 ± 3.78 mmHg in the left eyes. The mean IOP measured an hour after the patients became normotensive was 13.78 ± 4.06 mmHg in the right and 13.51 ± 3.82 in the left eyes. There was a statistically significant decrease in the IOPs (P < 0.001). The mean IOP in the control group was 13.54 ± 3.51 mmHg in the right and 13.20 ± 3.33 mmHg in the left eyes. The mean IOP at presentation in the study and control groups was found to be significantly different (P < 0.001).

CONCLUSIONS:
Patients in the study group showed a significantly higher IOP compared to patients in the normotensive group. Furthermore, patients in the study group showed a significant reduction in IOP after BP reduction. This may indicate that uncontrolled hypertension poses a risk for prolonged higher IOP. Prolonged higher IOP can be considered a risk factor for the glaucoma.
Incidence and seasonal variation of hospital admissions for acute bronchiolitis among children younger than two years in a Northern Emirates hospital
Authors: Saeed Balsam Qubais , Sharif Hanan Abdulgader , Al-Shahrabi Rula , Adrees Ahmed Omar , Alkokhardi Zainab Mansour 
Published: August 2022

Background:
There is limited information about acute bronchiolitis (AB) in the United Arab Emirates. The study aims to describe incidents, hospitalizations, and seasonal variation of AB among children less than 2 years.

Methods:
The retrospective data were collected for children ≤24 months who were admitted in the University Hospital Sharjah with AB from January 1, 2018 to December 31, 2019. Demographic characteristics, vital signs, management, admission data, cases seasonality, maternity history, and co-infections related to the cases were analyzed.

Results:
A total of 2496 AB cases were reported. Males and children more than 6 months were more infected than females and infants ≤ 6 month. Most of the cases were from emergency room, discharged within the same day and delivered by normal vaginal delivery. Respiratory syncytial virus (RSV) was the commonest cause of AB. Other etiological agents included influenza viruses, adenoviruses, Streptococcus spp., and Mycoplasma pneumoniae. The seasonal variation peak of AB for the 2 years was found in the Autumn months, with a small peak reported in the beginning of Spring months. The number of AB cases in 2019 was greater than that in 2018.

Conclusion:
AB is a common reason for hospitalization among males and children more than 6 months during the Autumn season. RSV is the common responsible virus for hospital admissions and morbidity. Our results may guide effort toward healthcare provision and implementation of AB prevention.
Evaluating the impact of sociodemographics and BMI on social anxiety among the students of the University of Sharjah
Authors: Dalla Emad Eddin , Maziek Abdulrahman , Hamood Shorouq , AlRaeesi Hayat , Mogharbel Afaf , Omran Shamma 
Published: August 2022

Background:
The association between social anxiety and specific confounders such as body mass index (BMI) and gender has not been studied in the UAE yet. This study aims to assess the impact of sociodemographics and BMI on social anxiety levels among the university students.

Methods:
A questionnaire-based cross-sectional study was performed on 578 students using a modified version of the established and validated self-administered “Social Anxiety Questionnaire-Adult 30” (SAQ-A30), which aims to assess social anxiety across five different dimensions. Furthermore, height and weight measurements were obtained using manual scales to calculate the participants’ BMI.

Results:
About 553 students were eligible for data analysis. Based on analytical tests, the female gender was associated with increased social anxiety (P<0.05). In addition, negative changes of body self-perception were associated with increased social anxiety scores among college students (P<0.0001). However, we found no correlation between social anxiety levels and different BMI groups among the university students.

Conclusion:
Social anxiety levels increase based on gender and change of body self-perception after entering college in students.
Serum vitamin D level and micro-ribonucleic acid-146a expression pattern in dry eye disease associated with rheumatoid arthritis in an Egyptian population
Authors: Shousha Shireen M. , EL-Ghobashy Nehal , Alhelf Maha , El-kareem Dalia Abd , Moawad Pavly 
Published: August 2022

Aim
The aim of this research was to study serum vitamin D and micro-ribonucleic acid-146a (miRNA-146a) expression in dry eye disease (DED) associated with rheumatoid arthritis (RA) and their clinical correlations to DED parameters.

Setting and design
This is an observational cross-sectional study that was conducted at Cairo University, Cairo, Egypt.

Patients and methods
The study participants were divided into three groups: group A, DED/RA (n=35); group B, non-DED/RA (n=36); and group C, non-DED/non-RA (n=35). All participants were assessed for ocular surface disease index, tear breakup time (TBUT), serum level of vitamin D, and miRNA-146a expression. In the DED group (with TBUT<10 s), DED evaluation was performed, including Schirmer I test, corneal and conjunctival scoring, and impression cytology.

Results
The mean serum vitamin D level was 17.1±16.2 ng/ml in group A, 35.1±13.4 ng/ml in group B, and 38.1±8.7 ng/ml in group C, with a statistically significant difference (P<0.001). The mean miRNA-146a expression was 4.7±1.5 in group A compared with 4.8±1.8 in group B (P=0.959) and 1.0±0.1 in group C (P<0.001, compared with each of groups A and B). In group A, serum vitamin D level showed a significant moderate negative correlation to each of impression cytology grading (r=−0.456, P=0.019) and miRNA-146a expression (r=−0.387, P=0.041). Both serum vitamin D and miRNA-146a expression showed nonsignificant correlations to ocular surface disease index, TBUT, Schirmer I test, and corneal and conjunctival scoring.

Conclusion
DED associated with RA showed a statistically significantly lower serum level of vitamin D, which was negatively correlated to impression cytology grading and miRNA-146a expression. Expression of miRNA-146a did not differ between the dry eye and non-dry eye RA groups.
Quantitative assessment of xanthelasma palpebrarum treated by argon laser photocoagulation using ImageJ software
Authors: Salamah Moustafa A. , Elsayed Tamer G. 
Published: August 2022

Purpose
The aim of this study was to evaluate the effect of argon laser photocoagulation on xanthelasma using ImageJ software.

Patients and methods
The study included 41 eyes of 23 patients (49 individual xanthelasmic lesions). All lesions were treated by a single session of argon laser photocoagulation. The lesions were assessed prelaser and postlaser using ImageJ software.

Results
All xanthelasmic lesions improved in height and color. The pretreatment mean height in ImageJ was 168.93±11.64 pixels, while the mean posttreatment height was 131±8.39 pixels (P<0.001). The color moderately improved in 24.4% of the cases and markedly improved in 68.3% of the cases.

Conclusion
Argon laser treatment of xanthelasma is a safe and effective treatment modality. This finding was documented using ImageJ software.
Lateral tarsal strip vs. lower lid retractors reinsertion for treatment of involutional entropion
Authors: Ezzeldin Ezzeldin R. 
Published: August 2022

Purpose
The aim of this study was to report the clinical efficacy of lateral tarsal strip (LTS) procedure for correction of senile entropion compared with lower lid retractors reinsertion.

Patients and methods
This is a retrospective comparative, nonrandomized interventional study that was conducted on patients attending the outpatient clinic of the Ophthalmology Department in Al Azhar University Hospital (Damietta branch), Damietta, Egypt, during the period from February 2019 to April 2021. The study recruited 56 lower eyelids of 44 patients who had involutional entropion; 12 of them were bilateral. In 29 eyelids, LTS procedure (group 1) was performed, whereas 27 eyelids were treated by lower lid retractors reinsertion (group 2).

Results
There were no statistically significant differences between the two groups regarding age, sex, and laterality. Regarding the postoperative correction of entropion, the first group (treated by LTS procedure) achieved a 100% success rate, whereas the second group (treated by lower lid retractors reinsertion) had a success rate of 81.5%, with a statistically significant difference (P=0.015). Although lid lag occurred only in the second group, it was not statistically significant.

Conclusion
The advantages of the LTS procedure over the lower lid retractors reinsertion are less risk of undercorrection and good cosmetic acceptance of the lid margin because of the stability of the lid margin that is achieved by the LTS procedure.
Comparison between therapeutic effects of 0.18% sodium hyaluronate and 1% carboxymethyl cellulose on ocular surface damage induced by anti-glaucoma medications
Authors: Maheshwari Meemansha , Jain Amit K. , Singh Naveen K. , Singh Neha , Nath Tirupati 
Published: August 2022

Purpose
This study was conducted to compare the therapeutic effect of 1% carboxymethyl cellulose (CMC) and 0.18% sodium hyaluronate (SH) on ocular surface damage induced by various anti-glaucoma medications.

Patients and methods
The study included 100 patients who were diagnosed as having primary open-angle glaucoma, normal tension glaucoma, or ocular hypertension and were on anti-glaucoma drugs. The patients were divided in two groups: group A patients received 1% CMC, whereas group B patients received 0.18% SH for 3 months. The severity of ocular surface disease symptoms was assessed by the ocular surface disease index (OSDI) questionnaire. Ocular examination with tear film break-up time, fluorescein staining, Schirmer's test, and conjunctival impression cytology was performed sequentially on days 0, 30, and 90.

Results
Both CMC-treated and SH-treated groups showed improvement in the OSDI scores at days 30 and 90. However, the OSDI scoring was statistically significantly better in the SH group at both follow-up intervals (P<0.05). Fluorescein staining improved significantly with SH compared with CMC at day 30 (P<0.03). Schirmer's test, tear film break-up time, and conjunctival impression cytology improved in both drugs. However, the difference was not statistically significant (P>0.5).

Conclusion
Both SH and CMC improved the symptoms and signs of ocular surface damage caused by the preservatives used in anti-glaucoma medication. However, SH showed faster efficacy than the CMC-based formulation.
Corneal epithelial profile in psoriasis patients with and without dry eye disease
Authors: Tolba Doaa A. , Esmat Sara M. , AlOrbani Aya M. , Amin Rana H. 
Published: August 2022

BackgroundPsoriasis is an immune-mediated systemic inflammatory disease in which corneal affection takes various forms such as dry eye disease (DED), punctate epithelial keratitis, and sterile corneal infiltrates.PurposeThe aim of this study was to evaluate the corneal epithelial profile of psoriasis patients using anterior segment optical coherence tomography (AS-OCT).Patients and methodsThis is a cross-sectional analytic study that included 81 eyes: 39 eyes of 20 psoriasis patients and 42 eyes of 21 healthy age-matched and sex-matched controls. They were divided into three groups: psoriasis patients with dry eye disease (PDED), psoriasis patients without DED (PS), and healthy subjects (HS). AS-OCT was done to study the epithelial profile data of each eye and to correlate any finding with the disease activity evaluated by the Psoriasis Area and Severity Index score and disease extent.ResultsThe PDED patients showed significantly lower central corneal thickness (CCT), higher central epithelial thickness (CET), and thicker inferior epithelium (P=0.004, 0.002, and 0.005, respectively). A significantly thinner superior epithelium was detected in the PS group compared with the PDED and HS groups (P=0.001 and 0.010, respectively). In addition, the topographic thickness variability (SD) and minimim–maximum were significantly higher in both the PDED and PS groups compared with the HS group (P<0.001). The CCT showed a significantly positive correlation with the tear breakup time (r=0.373,P=0.020), while the CET showed a significantly negative correlation with it (r=−0.331,P=0.040). The CET also had a significant positive correlation with disease duration (r=0.390,P=0.014) and disease extent (r=0.323,P=0.045).ConclusionAS-OCT has proved to be a valuable method for screening and detecting the corneal whole thickness and epithelial thickness abnormalities in psoriasis patients in the presence or absence of DED. The presence of thicker epithelium and thinner CCT were significant findings in the PDED, while in psoriasis patients without DED, superior epithelial thinning was the significant finding. A statistically significant high topographic thickness variability was detected in both groups compared with the controls.
Role of sex in retinal nerve fiber layer and macular thickness measurement by spectral domain optical coherence tomography
Authors: Sood Amit , Jain Vibhor , Gupta Megha , Paliwal Rahul O. , Mishra Rishu 
Published: August 2022

Purpose
The aim of this study was to investigate the role of sex on retinal nerve fiber layer (RNFL) thickness and macular thickness measurement by spectral domain optical coherence tomography (SD-OCT).

Patients and methods
In this prospective observational study, 200 participants who fulfilled the inclusion and exclusion criteria were scanned three times as per predefined guidelines at 0, 30, and 60 min on the same day, by the same investigator using SD-OCT for measurement of RNFL and macular thickness. The observations were statistically analyzed and correlated.

Results
The RNFL thickness was greatest in the superior quadrant and thinnest in the temporal quadrant. The mean value of average RNFL thickness was 87.90±6.12 μm in females and 93.18±4.04 μm in males (range=74.33–99.67 μm). A statistically significant difference was found between males and females in all quadrants and in average RNFL thickness (P<0.0005). The macular thickness was thinnest at the central zone (innermost 1-mm ring), thickest within the inner 3-mm ring, and diminished peripherally. The mean macular thickness was 272.95±8.40 μm in females and 289.42±12.32 μm in males. A statistically significant difference was found between males and females in all macular zones and in the mean macular thickness (P<0.0005).

Conclusion
RNFL thickness and macular thickness were significantly thicker in males compared with females in healthy eyes. Sex should be used as an additional parameter in commercially available OCT machines, in addition to age, because of its potential in improving the existing RNFL thickness and macular thickness norms.
Evaluating corneal changes after corneal collagen cross-linking in keratoconus by optical coherence tomography
Authors: Barakat Abdallah , Elmassry Ahmed , Othman Ihab , El-Kateb Mohamed 
Published: August 2022

Purpose
The aim of this study was to evaluate the corneal changes after corneal collagen cross-linking (CXL) in progressive keratoconus using anterior segment optical coherence tomography.

Patients and methods
This prospective interventional noncomparative case-series study was conducted on 30 eyes of 18 patients of both sexes with a mean age of 23.11±4.06 years diagnosed as progressive keratoconus patients with clear central cornea. All eyes underwent epithelium-off accelerated CXL. Anterior segment optical coherence tomography and Scheimpflug camera imaging were done to all cases preoperatively and at 1, 3, and 6 months, postoperatively.

Results
The demarcation line (DL) was detected in all eyes 1 month postoperatively, and was still detected at 3 and 6 months, postoperatively. However, it was accurately measured until 3 months postoperatively. At 6 months, it was barely visible, so measuring its depth was difficult to be done. There was a statistically significant positive correlation between the thinnest corneal thickness and the central corneal DL depth (r=0.480, P=0.006). There was no statistically significant correlation between the maximum keratometric reading (K-max) and the depth of central corneal DL (r=−0.253, P=0.17). In addition, there was no statistically significant correlation between corneal densitometry and the depth of central corneal DL (r=−0.68, P=0.715).

Conclusions
The DL is a direct clinical sign of corneal CXL and can be found within 6 months after the treatment, being most clearly visible at 1 month after CXL. However, the line starts to be less visible after 3 months and becomes barely visible after 6 months postoperatively, making it difficult to measure its depth at that time.