bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brexit Sovereignty and its Dead Ends
Authors: Eeckhout Piet 
Published: April 2022

AbstractIn more ways than one, the Trade and Cooperation Agreement (TCA) concluded by the EU and the UK is a typical trade agreement. Its commitments are international in nature; its provisions create no directly effective rights and obligations for private parties to enforce under domestic law. The TCA thus turns from the central innovation of EU law, an innovation, which also lies at the heart of the Single Market. It is a price the UK is willing to pay for throwing off what it considers the yoke of EU law. This is not out of tune, perhaps, with a wider popular pushback against globalisation and the institutions perceived to represent it. But has Brexit truly returned control of its own laws to the UK, in both a formal and a practical sense? This article analyses the TCA as a balancing act between the parties’ ‘right to regulate’ and the EU’s demand of a level playing field, the ‘Brussels effect’ likely to constrain British attempts in the direction of regulatory divergence, and what has become of the formal effect of EU law in the laws of the UK.
Taking Back Control as Democratic Theory
Authors: Weale Albert 
Published: April 2022

AbstractThe slogan ‘take back control’ was central to Brexit. The conception of democracy this slogan embodies is the traditional Westminster model. It is a model in the sense that it is supposed to provide a simplified characterisation of the operative principles of UK politics and government, although practice in fact diverges from those principles. It is also a model in the sense that the Westminster system is seen by those favouring Brexit as an ideal to which practice needs to be restored. The model can be associated with a corresponding conception of democracies in the international order. However, there are both functional and democratic disadvantages with that account of democracy and the international order, disadvantages that the development of the EU highlights. Two alternative models of democracy beyond the nation state are identified, before concluding that the Westminster model has a past but not a future.
Positive effects of organic viticulture on carabid beetles depend on landscape and local habitat conditions
Authors: Schirmel Jens , Petschner Stefan , Rösch Verena , Entling Martin H. 
Published: April 2022

AbstractAgricultural intensification is a major cause of biodiversity loss. Organic farming may counteract the loss of species, however, knowledge about its benefits for perennial agroecosystems such as vineyards is incomplete. We, therefore, analysed the effects of organic viticulture on carabid beetles, a frequently used indicator group in agroecology. We investigated organic and conventional vineyards in two different landscapes (‘simple’ vs. ‘complex’) in SW Germany using a paired design. As a key result we found positive effects of organic viticulture on carabid diversity only in the simple landscape while such an effect was not obvious in the more complex landscape. Moreover, the species composition was differently influenced by organic management between the two landscapes indicating context‐dependent responses of carabid species towards the farming practice. We conclude that positive effects of organic viticulture on carabid beetle diversity differ with landscape context and depend on local habitat conditions such as slope inclination and the inter‐row vegetation. Our results therefore indicate that organic viticulture benefits are not only highly variable among taxonomic groups, but can have even varying effects within one insect family.
Effect of olfactory bulb pathology on olfactory function in normal aging
Authors: Tremblay Cécilia , Serrano Geidy E. , Intorcia Anthony J. , Sue Lucia I. , Wilson Jeffrey R. , Adler Charles H. , Shill Holly A. , Driver‐Dunckley Erika , Mehta Shyamal H. , Beach Thomas G. 
Published: April 2022

AbstractDecline of olfactory function is frequently observed in aging and is an early symptom of neurodegenerative diseases. As the olfactory bulb (OB) is one of the first regions involved by pathology and may represent an early disease stage, we specifically aimed to evaluate the contribution of OB pathology to olfactory decline in cognitively normal aged individuals without parkinsonism or dementia. This clinicopathological study correlates OB tau, amyloid β (Aβ) and α‐synuclein (αSyn) pathology densities and whole brain pathology load to olfactory identification function as measured with the University of Pennsylvania Smell Identification Test (UPSIT) and clinical data measured proximate to death in a large autopsy study including 138 cases considered non‐demented controls during life. Tau pathology was frequently observed in the OB (95% of cases), while both Aβ (27% of cases) and αSyn (20% of cases) OB pathologies were less commonly observed. A weak correlation was only observed between OB tau and olfactory performance, but when controlled for age, neither OB tau, Aβ or αSyn significantly predict olfactory performance. Moreover, whole brain tau and αSyn pathology loads predicted olfactory performance; however, only αSyn pathology loads survived age correction. In conclusion, OB tau pathology is frequently observed in normally aging individuals and increases with age but does not appear to independently contribute to age‐related olfactory impairment suggesting that further involvement of the brain seems necessary to contribute to age‐related olfactory decline.
Impact of low iodine diets on ablation success in differentiated thyroid cancer: A mixed‐methods systematic review and meta‐analysis
Authors: Herbert Georgia , England Clare , Perry Rachel , Whitmarsh Alex , Moore Theresa , Searle Aidan , Chotaliya Sneha , Ness Andy , Beasley Matthew , Atkinson Charlotte 
Published: April 2022

AbstractBackgroundDebate remains regarding whether to recommend a low iodine diet (LID) before radioactive‐iodine treatment and its duration and stringency. This mixed‐methods review aimed to determine if iodine status affects treatment success, the most effective diet to reduce iodine status, and how LID impacts wellbeing.MethodsFive electronic databases were searched until February 2021. An effectiveness synthesis (quantitative studies) and views synthesis (qualitative, survey, and experience‐based evidence) were conducted individually and then integrated. Quality assessment was undertaken.ResultsFifty‐six quantitative and three qualitative studies were identified. There was greater ablation success for those with an iodine status of <50 mcg/L (or mcg/gCr) compared with ≥250 (odds ratio [OR] = 2.63, 95% confidence interval [CI], 1.18–5.86, n = 283, GRADE certainty of evidence very low). One study compared <50 mcg/L (or mcg/gCr) to 100–199 and showed similar rates of ablation success (OR = 1.59, 95% CI, 0.48–6.15, n = 113; moderate risk of bias). People following a stricter LID before ablation had similar rates of success to a less‐strict diet (OR = 0.67, 95% CI, 0.26–1.73, n = 256, GRADE certainty of evidence very low). A stricter LID reduced iodine status more than a less strict (SMD = −0.40, 95% CI, −0.56 to −0.24, n = 816), and reduction was seen after 1 and 2 weeks. The main challenges were a negative impact on psychological health, over restriction, confusion, and difficulty for sub‐groups.ConclusionsAlthough a LID of 1–2 weeks reduces iodine status, it remains unclear whether iodine status affects treatment success as only a few low‐quality studies have examined this. LIDs are challenging for patients. Higher‐quality studies are needed to confirm whether a LID is necessary.
Minimal invasive treatment for post‐liver and renal transplant lymphatic leaks
Authors: Liu Hsien‐Tzu , Liu Chien‐An , Wang Hsin‐Kai , Chen Cheng‐Yen , Liu Chin‐Su , Shen Shu‐Huei 
Published: April 2022

AbstractIntroductionPersistent lymphatic leakage from the surgical drain is a troubling complication occasionally encountered postoperatively. This study investigated lymphatic leaks after renal or liver transplantation, comparing the treatment efficacy of traditional catheter drainage vs. minimally invasive lymphatic interventions. We also discuss access and treatment targets considering the physiology of lymphatic flow.MethodsBetween September 2018 and September 2020, 13 patients with lymphatic leakage were treated with minimally invasive lymphatic interventions; 11 had received a renal transplant, and two received a liver transplant. The control group included 10 patients with postrenal transplant lymphatic leakage treated with catheter drainage. The treatment efficacy of catheter drainage, lymphatic interventions, and different targets of embolization were compared.ResultsThe technical success rate for lymphatic intervention was 100%, and the clinical success rate was 92%, with an 82.9% reduction in drain volume on the first day after treatment. The duration to reach clinical success was 5.9 days with lymphatic intervention, and 33.9 days with conservative catheter drainage.ConclusionLymphangiography and embolization are minimally invasive and efficient procedures for treating persistent lymphatic leaks after renal or liver transplantation. We suggest prompt diagnosis and embolization at upstream lymphatics to reduce the duration of drain retention, days of hospitalization, and associated comorbidities.
Point‐of‐care ultrasound for identification of ruptured infrarenal abdominal aortic aneurysm
Authors: Rhudy Anne Kelly , Patel Shivik , Houser Alex , Irfan Wajeeh , Sheahan Malachi 
Published: April 2022

AbstractRuptured abdominal aortic aneurysms (rAAA) are associated with high mortality rates and require prompt diagnosis with subsequent intervention. CT scan is considered the gold standard for diagnosis, however, in the acute setting ultrasound may be a reasonable diagnostic test for certain patients. We report a case that demonstrates the utility of point‐of‐care ultrasound (PoCUS) in diagnosing rAAA for a patient in extremis. Also, we provide a brief review of literature for the diagnosis of rAAA with ultrasound.
Comprehensive lipidomics of lupus‐prone mice using LC–MS/MS identifies the reduction of palmitoylethanolamide that suppresses TLR9‐mediated inflammation
Authors: Ozaki Takashi , Kamiyama Naganori , Saechue Benjawan , Soga Yasuhiro , Gotoh Ryo , Nakayama Tatsuya , Fukuda Chiaki , Dewayani Astri , Chalalai Thanyakorn , Ariki Shimpei , Ozaka Sotaro , Sonoda Akira , Hirose Haruna , Gendo Yoshiko , Noguchi Kaori , Sachi Nozomi , Hidano Shinya , Maeshima Keisuke , Gotoh Koro , Masaki Takayuki , Ishii Koji , Osada Yoshio , Shibata Hirotaka , Kobayashi Takashi 
Published: April 2022

AbstractLipid mediators are known to play crucial roles not only in the onset of the inflammatory response but also in the induction of resolution of inflammation. Here, we report that palmitoylethanolamide (PEA), an endogenous N‐acylethanolamine, can suppress the inflammation induced by Toll‐like receptor (TLR) signaling both in vitro and in vivo. PEA was found to be significantly reduced in the serum and spleen of lupus‐prone MRL/lpr mice analyzed by lipidomics. PEA suppressed pro‐inflammatory cytokine production in a mouse macrophage cell line stimulated with TLR ligands such as lipopolysaccharide, peptidoglycan, poly (I:C), imiquimod, and CpG‐ODN. PEA also inhibited both mRNA and protein levels of IL‐6 in bone marrow‐derived dendritic cells (BMDCs) and B cells stimulated with CpG‐ODN. Augmentation of cell surface CD86 and CD40 on BMDCs and B cells, IgM production, and cell proliferation of B cells in response to CpG‐ODN were attenuated by PEA. Moreover, PEA treatment significantly reduced mortality and serum IL‐6 levels in mice injected with CpG‐ODN plus D‐galactosamine. Taken together, PEA ameliorates inflammation induced by TLR signaling, which could be a novel therapeutic target for inflammatory disorders.
A review of bubble hair deformity
Authors: Li Yumeng M. , Diaz‐Perez Julio A. , Obayomi Aderonke , Galimberti Fabrizio , Romanelli Paolo , Tosti Antonella 
Published: April 2022

AbstractBubble hair deformity is an acquired abnormality characterized by air‐filled cavity formations within the hair shaft, usually because of heat damage. Traditionally, bubble hair is diagnosed by visualization of characteristic bubbles under light microscopy. The increased utilization of trichoscopy (scalp dermoscopy) has led to its adoption in the diagnosis of many hair and scalp conditions, including bubble hair deformity. We sought to review clinical reports evaluating the patient profile, use of diagnostic imaging, and treatment options for bubble hair deformity. A systematic search of PubMed was performed in February 2021 using various keywords. Titles and abstracts were screened, leading to the selection of 11 case reports or series. The majority of patients were middle‐aged Caucasian women who had used a heated tool to dry or style wet hair. Treatment consisted of cessation of heated tool usage. Light microscopy visualization of characteristic hair shaft cavities was used for diagnosis of bubble hair deformity in reports published prior to 2012. Diagnosis by trichoscopy was used in more recent reports. Our findings support the use of trichoscopy as a convenient and noninvasive method of diagnosing bubble hair deformity. More clinical studies are needed to evaluate the development of bubble hair deformity in ethnic hair.
Surface energies in high‐entropy carbides with variable carbon stoichiometry
Authors: Meng Hong , Chu Yanhui 
Published: April 2022

AbstractThe carbon vacancy in high‐entropy carbides (HECs) has a significant impact on their physical and chemical properties, yet relevant studies have still been relatively few. In this study, we investigate the surface energies of HECs with variable carbon vacancies through first‐principles calculations. The results show that the surface energy of the (1 0 0) surface of the stoichiometric HECs is significantly lower than that of (1 1 1) surface. With the decrease in carbon stoichiometry, the surface energies of both (1 0 0) and (1 1 1) surfaces increase gradually, which is mainly due to the weakening of covalent bonding and the decrease of metal Hirshfeld‐I (HI) charges. However, the surface energy of (1 0 0) surface increases more quickly than that of (1 1 1) surface and will exceed that of (1 1 1) surface when the carbon stoichiometry decreases to a certain extent, which is primarily attributed to the greater decrease rate of metal HI charges of (1 0 0) surface.
Fathers with their Children at an Art Exhibition: A Narrative Study
Authors: Acer Dilek , Baş Tuğba , Teke Nergiz 
Published: April 2022

AbstractThe aim of this study was to examine the early childhood experiences of children visiting an art exhibition with their fathers and creating their own artwork. It was designed and conducted as a narrative study, which is a qualitative research methodology. Five children in early childhood (48–88 months old) and their fathers participated in the research carried out in a Contemporary Arts Centre in Ankara, Turkey. Each father and child dyad visited the exhibition at different times and their dialogues during these visits were recorded. The data obtained in the study were analysed through content analysis. It was shown in the results that the fathers and children expressed their thoughts about features of the exhibited works such as size, line, transparency and texture as well as other aspects such as the part‐whole relationship and the materials and techniques used in the artworks. It was also observed in the process of creating images, that the fathers and their children had experiences in planning and initiating the creation process, continuing the drawing/colouring process, associating their artwork with the exhibition, naming their artwork and creating a common symbol. In addition, it was found that the fathers created narratives stating that they learned more about the perspective of their children regarding art, got to better know their children’s interests due to the artistic experience and decided to have more frequent artistic experiences with their children in the future.
Does emotion dysregulation mediate the association between ADHD symptoms and internalizing problems? A longitudinal within‐person analysis in a large population‐representative study
Authors: Antony Evelyn Mary‐Ann , Pihlajamäki Milla , Speyer Lydia Gabriela , Murray Aja Louise 
Published: April 2022

BackgroundPrevious research has suggested that children with attention‐deficit/hyperactivity disorder (ADHD) symptoms commonly show emotion dysregulation difficulties. These difficulties may partly explain the strong tendency for internalizing problems such as anxiety and depression to co‐occur with ADHD symptoms. However, no study has yet provided a longitudinal analysis of the within‐person links between ADHD symptoms, emotion dysregulation, and internalizing problems necessary to examine this hypothesis from a developmental perspective.MethodsWe used data from the age 3, 5, and 7 waves of the large UK population‐representative Millennium Cohort Study (n = 9,619, 4,885 males) and fit gender‐stratified autoregressive latent trajectory models with structured residuals (ALT‐SR) to disaggregate within‐ and between‐person relations between ADHD symptom, emotion dysregulation, and internalizing problem symptoms.ResultsWe found that emotion dysregulation significantly mediated the longitudinal within‐person association between ADHD symptoms and internalizing problems.ConclusionsResults underline the promise of targeting emotion dysregulation as a means of preventing internalizing problems co‐occurring with ADHD symptoms.
Complexities of care: Common components of models of care in geriatrics
Authors: McNabney Matthew K. , Green Ariel R. , Burke Meg , Le Stephanie T. , Butler Dawn , Chun Audrey K. , Elliott David P. , Fulton Ana Tuya , Hyer Kathryn , Setters Belinda , Shega Joseph W. 
Published: April 2022

AbstractAs people age, they are more likely to have an increasing number of medical diagnoses and medications, as well as healthcare providers who care for those conditions. Health professionals caring for older adults understand that medical issues are not the sole factors in the phenomenon of this “care complexity.” Socioeconomic, cognitive, functional, and organizational factors play a significant role. Care complexity also affects family caregivers, providers, and healthcare systems and therefore society at large. The American Geriatrics Society (AGS) created a work group to review care to identify the most common components of existing healthcare models that address care complexity in older adults. This article, a product of that work group, defines care complexity in older adults, reviews healthcare models and those most common components within them and identifies potential gaps that require attention to reduce the burden of care complexity in older adults.
Rapid sequence and functional diversification of a miRNA superfamily targeting calcium signaling components in seed plants
Authors: Attri Komal , Zhang Zijie , Singh Atinder , Sharrock Robert A. , Xie Zhixin 
Published: April 2022

Summary

MicroRNA (miRNA)‐directed posttranscriptional gene silencing (miR‐PTGS) is an integral component of gene regulatory networks governing plant development and responses to the environment. The sequence homology between Sly‐miR4376, a miRNA common to Solanaceae and reported to target autoinhibited Ca2+‐ATPase 10 (ACA10) messenger RNA (mRNA) in tomato, and Arabidopsis miR391 (Ath‐miR391), previously annotated as a nonconserved member of the deeply conserved miR390 family, has prompted us to revisit the function of Ath‐miR391, as well as its regulatory conservation.

A combination of genetic, molecular, and bioinformatic analyses revealed a hidden conservation for miR‐PTGS of ACA10 homologs in spermatophytes.

We found that the Arabidopsis ACA10 mRNA undergoes miR391‐directed cleavage in vivo. Furthermore, transgenic overexpression of miR391 recapitulated the compact inflorescence (cif) phenotypes characteristic of ACA10 loss‐of‐function mutants, due to miR391‐directed PTGS of ACA10. Significantly, comprehensive data mining revealed robust evidence for widespread PTGS of ACA10 homologs directed by a superfamily of related miRNAs sharing a conserved sequence core. Intriguingly, the ACA‐targeting miRNAs in Poaceae also direct PTGS for calmodulin‐like proteins which are putative Ca2+ sensors.

The PTGS of ACA10 homologs is therefore directed by a miRNA superfamily that is of ancient origin and has undergone rapid sequence diversification associated with functional innovation.
Dental anomalies in non‐syndromic orofacial clefts: A clinical approach
Authors: das Neves Lucimara Teixeira , de Carvalho Izabel Maria Marchi , Cobourne Martyn T. , Gomide Marcia Ribeiro 
Published: April 2022

AbstractOrofacial clefts (OC) represent some of the most common congenital malformations and affect multiple structures in the craniofacial region. There are a wide range of morphological OC types within the spectrum of both non‐syndromic OC (NSOC) and syndromic OC, including cleft lip (CL), cleft lip and palate, (CLP), and cleft palate (CP). Here, we describe the most frequent dental anomalies seen in the permanent dentition of individuals with NSOC, comparing them between the three main cleft types (CL, CLP, and CP). We present these findings from the perspective of prevalence relating to each anomaly, as well as the clinical characteristics and potential impact on the rehabilitation process. The investigation of dental anomalies associated with NSOC is important, helping to expand the phenotypic characterization of NSOC, improve the initial diagnostics, and establish appropriate rehabilitation and counseling.
Transient breast livedo reticularis‐like exanthem in an adolescent with COVID‐19
Authors: Andina‐Martinez David , Martín‐Fernández Carmen , Noguero‐Morel Lucero , Torrelo Antonio 
Published: April 2022

AbstractLivedo reticularis‐like eruptions have been described in different viral infections. In patients with COVID‐19, livedo reticularis‐like rashes are usually mild, typically present in a symmetric distribution and mostly involve the lower limbs. A case of livedo reticularis located exclusively on the breasts of a girl with mild systemic symptoms of COVID‐19 is presented. Coagulation studies were normal and findings disappeared within 1 week.
Nuclear copies of mitochondrial DNA as a potential problem for phylogenetic and population genetic studies of Odonata
Authors: Ožana Stanislav , Dolný Aleš , Pánek Tomáš 
Published: April 2022

AbstractThe use of mitochondrial markers for taxonomic identification and biodiversity monitoring is not without risks or limitations. Most importantly, the natural transfer of DNA from the mitochondria to the nucleus generates nonfunctional nuclear copies of mitochondrial DNA (NUMTs). Their abundance and size vary significantly among taxa, and NUMTs have been reported to complicate molecular studies based on mitochondrial markers in several insect orders, most prominently in Orthoptera. The significance of this phenomenon in Odonata has not yet been properly addressed. Here, we present a complete mitochondrial genome and a draft nuclear genome of Leucorrhinia albifrons (Odonata: Libellulidae), as well as NUMT and cox1 sequences from the related species Leucorrhinia dubia. We document the presence of NUMTs in the L. albifrons nuclear genome and in nuclear genomes of two other Odonata species available in public databases. Our results show that NUMTs can have a serious impact on barcoding, phylogenetic, population and phylogeographic studies of Odonata, especially when the barcode is located in the cox1 gene, the most frequently used molecular marker for Odonata. We suggest that nad1 should be used alone or in combination with cox1 to minimize unintended confusion with NUMTs. Finally, we present a mitophylogenomic analysis of Odonata and document several cases of misidentified mitochondrial genomes belonging to species different from those indicated in public databases. In conclusion, our findings represent an important step for future metabarcoding studies of Odonata based on mitochondrial DNA markers.