bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemodynamic Assessment of Pregnant People with and without Obesity by Noninvasive Bioreactance: A Pilot Study
Authors: Figueiro-Filho Ernesto A. , Robinson Na T. S. , Carvalho Jose , Keunen Johannes , Robinson Monique , Maxwell Cynthia 
Published: February 2022

Abstract
Objective This study aimed to identify cardiovascular differences between pregnant people with and without obesity for trimester-specific changes in hemodynamic parameters using noninvasive cardiac output monitoring (NICOM).
Study Design This study is a pilot prospective comparative cohort between pregnant people with and without obesity. Hemodynamic assessment was performed with NICOM (12–14, 21–23, and 34–36 weeks) during pregnancy.
Results In first trimester, pregnant people with obesity had higher blood pressure, stroke volume (SV), total peripheral resistance index (TPRI), and cardiac output (CO). Pregnant people with obesity continued to have higher SV and cardiac index (second and third trimesters). During the first trimester, body mass index (BMI) positively correlated with SV, TPRI, and CO. Fat mass showed a strong correlation with TPRI. BMI positively correlated with CO during the second trimester and fat mass was positively associated with CO. During the third trimester, TPR negatively correlated with BMI and fat mass.
Conclusion Fat mass gain in the period between the first and second trimesters in addition to the hemodynamic changes due to obesity and pregnancy contribute to some degree of left ventricular diastolic dysfunction which was manifested by lower SVs. Future work should investigate the possible causative role of obesity in the cardiovascular changes identified in people with obesity.
Rate of Revision Hip Arthroscopy for Pediatric Femoroacetabular Impingement: A Systematic Review
Authors: Mojica Edward S. , Yedikian Teren , DeClouette Brittany , Hurley Eoghan T. , Gipsman Aaron , Castañeda Pablo , Youm Thomas 
Published: February 2022

AbstractFemoroacetabular impingement (FAI) can cause pain, dysfunction, and early arthritic progression in young patients. The purpose of this study was to systematically review the evidence in literature to determine patient-reported outcomes and failure rates as defined by the need for revision surgery, following hip arthroscopy for pediatric patients with FAI. The literature search was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Clinical studies evaluating the outcomes following primary hip arthroscopy for pediatric patients with FAI were included. Clinical outcomes evaluated included revisions, complications, functional outcome scores (modified Hip Harris Score [mHHS], Non-Arthritis Hip Score, and Visual Analogue Score), and return to play. Statistical analysis was performed using GraphPad Prism version 7. This study is a level IV systematic review. Overall, 20 clinical studies with 1,136 patients (1,223 hips) were included in this review, with an average age of 16.3 years. Overall, 8.6% patients experienced revision surgery. The mHHS was the most widely used metric, present in 17 of the 20 studies. The mHHS was reported as excellent (> 90) in six of these studies and good (80–89) in 11. The weighted mean of the post-operative mHHS found across reporting studies was 84.3, from a baseline score of 58.1. The overall return to play rate was 91%. This study reports excellent post-hip arthroscopy clinical outcomes for FAI and labral tears in the pediatric population. However, revision rates for this surgical procedure are higher than previously documented.
The Concept of a Rupture Risk Envelope for the Cochleo-Saccular Membranes
Authors: Pender Daniel J. 
Published: February 2022

Abstract
Introduction Alterations in endolymphatic pressure have long been suspected of being associated with the development of endolymphatic hydrops and rupture of the membranous labyrinth. More recently, there has been a focus on how membrane mechanics might contribute to membrane rupture. This is suspected to involve the viscoelastoplastic properties of these membranes.
Objective To construct a rupture risk envelope for the cochleo-saccular membranes based on viscoelastoplasticity to provide insight into lesion behavior in Meniere disease.
Methods Reported deformation data from a collagen model of the cochleo-saccular membranes was utilized. Yield stress was defined as 80% of ultimate failure stress. The yield points at various strain rates were used to construct a rupture risk envelope for the membranes.
Results The rupture risk envelope was found to be downward sloping in configuration. At the highest strain rate of 385% per minute, the membrane yield was associated with greater stress (7.0 kPa) and lesser strain (30%); while at the lowest strain rate of 19.2% per minute, there was substantially less membrane yield stress (4.3 kPa) but it was associated with greater strain (44%).
Conclusion The concept of a rupture risk envelope based on viscoelastoplasticity provides insight into hydropic lesion behavior in Meniere disease. This concept helps to explain how variations in membrane distensibility might occur as suspected in the double hit theory of lesion generation in Meniere disease. Slowly developing lesions would appear have a lower rupture risk while rapidly developing lesions would appear to have a greater risk of early membrane rupture.
Fat embolism syndrome in a patient with a right undisplaced femoral neck fracture
Authors: Ishikawa Junta , Sato Nobuhiro , Ishigame Naho , Ono Ayaka , Yamagishi Ikumi , Sakagami Atsushi , Sakai Yoshinori , Hirose Yasuo , Yabe Masahiro 
Published: February 2022

Abstract
Fat embolism syndrome (FES) is a rare condition characterised by the classic triad of respiratory distress, neurologic symptoms and petechial rash. Here, we encountered a case of FES in a patient with an asymptomatic right undisplaced femoral neck fracture (Garden Stage II). FES was diagnosed based on the Gurd and Willson’s diagnostic criteria and brain magnetic resonance imaging features. To the best of our knowledge, this is the first case of FES in a patient with an undisplaced femoral neck fracture. This study highlights the importance of considering the possibility of FES even in patients with undisplaced femoral neck fractures.
Challenges in Systematic Reviews and Meta-Analyses of Mediation Analyses
Authors: Vo Tat-Thang , Vansteelandt Stijn 
Published: February 2022

AbstractSystematic reviews and meta-analyses of mediation studies are increasingly being implemented in practice. Nonetheless, the methodology for conducting such review and analysis is still in a development phase, with much room for improvement. In this paper, we highlight and discuss challenges that investigators face in systematic reviews and meta-analyses of mediation studies and propose ways of accommodating these in practice.
Computational analyses of bacterial strains from shotgun reads
Authors: Ventolero Minerva Fatimae , Wang Saidi , Hu Haiyan , Li Xiaoman 
Published: February 2022

AbstractShotgun sequencing is routinely employed to study bacteria in microbial communities. With the vast amount of shotgun sequencing reads generated in a metagenomic project, it is crucial to determine the microbial composition at the strain level. This study investigated 20 computational tools that attempt to infer bacterial strain genomes from shotgun reads. For the first time, we discussed the methodology behind these tools. We also systematically evaluated six novel-strain-targeting tools on the same datasets and found that BHap, mixtureS and StrainFinder performed better than other tools. Because the performance of the best tools is still suboptimal, we discussed future directions that may address the limitations.
PST-PRNA: prediction of RNA-binding sites using protein surface topography and deep learning
Authors: Li Pengpai , Liu Zhi-Ping 
Published: February 2022

Abstract

Motivation
Protein–RNA interactions play essential roles in many biological processes, including pre-mRNA processing, post-transcriptional gene regulation and RNA degradation. Accurate identification of binding sites on RNA-binding proteins (RBPs) is important for functional annotation and site-directed mutagenesis. Experimental assays to sparse RBPs are precise and convincing but also costly and time consuming. Therefore, flexible and reliable computational methods are required to recognize RNA-binding residues.

Results
In this work, we propose PST-PRNA, a novel model for predicting RNA-binding sites (PRNA) based on protein surface topography (PST). Taking full advantage of the 3D structural information of protein, PST-PRNA creates representative topography images of the entire protein surface by mapping it onto a unit spherical surface. Four kinds of descriptors are encoded to represent residues on the surface. Then, the potential features are integrated and optimized by using deep learning models. We compile a comprehensive non-redundant RBP dataset to train and test PST-PRNA using 10-fold cross-validation. Numerous experiments demonstrate PST-PRNA learns successfully the latent structural information of protein surface. On the non-redundant dataset with sequence identity of 0.3, PST-PRNA achieves area under the receiver operating characteristic curves (AUC) value of 0.860 and Matthew’s correlation coefficient value of 0.420. Furthermore, we construct a completely independent test dataset for justification and comparison. PST-PRNA achieves AUC value of 0.913 on the independent dataset, which is superior to the other state-of-the-art methods.

Availability and implementation
The code and data are available at https://www.github.com/zpliulab/PST-PRNA. A web server is freely available at http://www.zpliulab.cn/PSTPRNA.

Supplementary information
Supplementary data are available at Bioinformatics online.
Psychiatric symptoms of frontotemporal dementia and subcortical (co-)pathology burden: new insights
Authors: Scarioni Marta , Gami-Patel Priya , Peeters Carel F W , de Koning Florianne , Seelaar Harro , Mol Merel O , van Swieten John C ,   Netherlands Brain Bank, Rozemuller Annemieke J M , Hoozemans Jeroen J M , Pijnenburg Yolande A L , Dijkstra Anke A 
Published: February 2022

AbstractThree subtypes of distinct pathological proteins accumulate throughout multiple brain regions and shape the heterogeneous clinical presentation of frontotemporal lobar degeneration (FTLD). Besides the main pathological subtypes, co-occurring pathologies are common in FTLD brain donors. The objective of this study was to investigate how the location and burden of (co-)pathology correlate to early psychiatric and behavioural symptoms of FTLD.Eighty-seven brain donors from The Netherlands Brain Bank cohort (2008–2017) diagnosed with FTLD were included: 46 FTLD-TAR DNA-binding protein 43 (FTLD-TDP), 34 FTLD-tau, and seven FTLD-fused-in-sarcoma (FTLD-FUS). Post-mortem brain tissue was dissected into 20 standard regions and stained for phosphorylated TDP-43, phosphorylated tau, FUS, amyloid-β, and α-synuclein. The burden of each pathological protein in each brain region was assessed with a semi-quantitative score. Clinical records were reviewed for early psychiatric and behavioural symptoms. Whole-brain clinico-pathological partial correlations were calculated (local false discovery rate threshold = 0.01). Elaborating on the results, we validated one finding using a quantitative assessment of TDP-43 pathology in the granular layer of the hippocampus in FTLD-TDP brain donors with (n = 15) and without (n = 15) hallucinations.In subcortical regions, the presence of psychiatric symptoms showed positive correlations with increased hippocampal pathology burden: hallucinations with TDP-43 in the granular layer (R = 0.33), mania with TDP-43 in CA1 (R = 0.35), depression with TDP-43 in CA3 and with parahippocampal tau (R = 0.30 and R = 0.23), and delusions with CA3 tau (R = 0.26) and subicular amyloid-β (R = 0.25). Behavioural disinhibition showed positive correlations with tau burden in the thalamus (R = 0.29) and with both TDP-43 and amyloid-β burden in the subthalamus (R = 0.23 and R = 0.24). In the brainstem, the presence of α-synuclein co-pathology in the substantia nigra correlated with disinhibition (R = 0.24), tau pathology in the substantia nigra correlated with depression (R = 0.25) and in the locus coeruleus with both depression and perseverative/compulsive behaviour (R = 0.26 and R = 0.32). The quantitative assessment of TDP-43 in the granular layer validated the higher burden of TDP-43 pathology in brain donors with hallucinations compared to those without hallucinations (P = 0.007).Our results show that psychiatric symptoms of FTLD are linked to subcortical pathology burden in the hippocampus, and hallucinations are linked to a higher burden of TDP-43 in the granular layer. Co-occurring non-FTLD pathologies in subcortical regions could contribute to configuring the clinical phenotype of FTLD.
Spatiotemporal and sensory modality attention processing with domain-specific representations in frontoparietal areas
Authors: Wang Luyao , Li Chunlin , Han Ziteng , Wu Qiong , Sun Liwei , Zhang Xu , Go Ritsu , Wu Jinglong , Yan Tianyi 
Published: February 2022

Abstract
The frontoparietal network (FPN), including bilateral frontal eye field, inferior parietal sulcus, and supplementary motor area, has been linked to attention processing, including spatiotemporal and sensory modality domains. However, it is unclear whether FPN encodes representations of these domains that are generalizable across subdomains. We decomposed multivariate patterns of functional magnetic resonance imaging activity from 20 participants into domain-specific components and identified latent multivariate representations that generalized across subdomains. The 30 experimental conditions were organized into unimodal–bimodal and spatial–temporal models. We found that brain areas in the FPN, form the primary network that modulated during attention across domains. However, the activation patterns of areas within the FPN were reorganized according to the specific attentional demand, especially when pay attention to different sensory, suggesting distinct regional neural representations associated with specific attentional processes within FPN. In addition, there were also other domain-specific areas outside the FPN, such as the dorsolateral prefrontal cortex. Our conclusion is that, according to the results of the analysis of representation similarity, 2 types of activated brain regions, related to attention domain detailed information processing and general information processing, can be revealed.
Infectious Diseases-Related Hospitalizations During Oral Polio Vaccine (OPV) and Non-OPV Immunization Periods: An Empirical Evaluation of all Hospital Discharges in California (1985–2010)
Authors: Contopoulos-Ioannidis Despina G , Altamirano Jonathan , Maldonado Yvonne 
Published: February 2022

Abstract

Background
Live attenuated vaccines such as oral polio vaccine (OPV) can stimulate innate immunity and may have off-target protective effects on other pathogens. We aimed to address this hypothesis by examining changes in infectious diseases (ID)-related hospitalizations in all hospital discharges in California during OPV (1985–1996) and non-OPV immunization periods (2000–2010).

Methods
We searched the Office of Statewide Health Planning and Development database for all hospital discharges with any ID-related discharge diagnosis code during 1985–2010. We compared the proportion of ID-related hospitalizations (with at least &#x2028;1 ID-related discharge diagnosis) among total hospitalizations during OPV immunization (1985–1996) versus non-OPV immunization (2000–2010) periods.

Results
There were 19 281 039 ID-related hospitalizations (8 464 037 with an ID-related discharge diagnosis as the principal discharge diagnosis for the hospitalization) among 98 117 475 hospitalizations in 1985–2010; 9 520 810 ID hospitalizations/43 456 484 total hospitalizations in 2000–2010 versus 7 526 957/43 472 796 in 1985–1996. The risk ratio for ID-related hospitalizations in 2000–2010 versus 1985–1996 was 1.27 (95% confidence interval [CI], 1.26–1.27) for all diagnoses and 1.15 (95% CI: 1.15–1.16) for principal diagnoses. Increases also existed in the proportion of lower respiratory and gastrointestinal infections.

Discussion
The proportion of ID-related hospitalizations was lower in the OPV immunization period compared to the period after OPV was discontinued. When focused only on hospitalizations with ID as the principal discharge diagnosis, the signal remained significant but was smaller. These findings require replication in additional studies.
A Posture of Protestation: Civil Litigation and Constitutional Culture in the Reformation-Era Holy Roman Empire
Authors: Ludin Sarah 
Published: February 2022

Abstract
What role did judicial courts play in the constitution of the early modern Holy Roman Empire? Scholars have shown that the frameworks of judicialization (which highlights the peaceful channelling mechanisms of law) and of instrumentalization (which underscores the political uses and abuses of law) are unsatisfactory for fully describing the ways in which high courts shaped and participated in the constitutional landscape of the early modern Empire. Yet historiography on the Reformation cases continues to operate within this rule-of-law/politics dichotomy. This article offers a new way of considering the constitutional significance of the Reformation cases by analysing uses of a legal instrument—the protestatio—in the context of civil litigation. While the protestation is well-known for its uses in the context of imperial diets, its uses in court—and in particular its centrality to the Protestant litigation strategy—have been ignored. This study illuminates not only a more complete account of the role of law and litigation in the history of the Reformation, but also a hitherto neglected dimension of the role of courts in constituting relations among the Empire’s rulers, centred on litigative practices and techniques—the constitutional culture of litigation. It argues that the work of litigation itself—not only in its jurisprudence or the substantive interpretations made, but also in the forms and language through which litigants were required to operate and argue—had a distinctively important role in constituting relations among the rulers of the early modern Holy Roman Empire.
A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation
Authors: Missaghian Parisa , Dierker Tabea , Khosrowabadi Elham , Axling Fredrik , Eriksson Inger , Ghanem Abdurrahman , Kusche-Gullberg Marion , Kellokumpu Sakari , Kjellén Lena 
Published: February 2022

Abstract
NDST1 (glucosaminyl N-deacetylase/N-sulfotransferase) is a key enzyme in heparan sulfate (HS) biosynthesis, where it is responsible for HS N-deacetylation and N-sulfation. In addition to the full length human enzyme of 882 amino acids, here designated NDST1A, a shorter form containing 825 amino acids (NDST1B) is synthesized after alternative splicing of the NDST1 mRNA. NDST1B is mostly expressed at a low level, but increased amounts are seen in several types of cancer where it is associated with shorter survival. In this study, we aimed at characterizing the enzymatic properties of NDST1B and its effect on HS biosynthesis. Purified recombinant NDST1B lacked both N-deacetylase and N-sulfotransferase activities. Interestingly, HEK293 cells overexpressing NDST1B synthesized HS with reduced sulfation and altered domain structure. Fluorescence resonance energy transfer-microscopy demonstrated that both NDST1A and NDST1B had the capacity to interact with the HS copolymerase subunits EXT1 and EXT2 and also to form NDST1A/NDST1B dimers. Since lysates from cells overexpressing NDST1B contained less NDST enzyme activity than control cells, we suggest that NDST1B works in a dominant negative manner, tentatively by replacing the active endogenous NDST1 in the enzyme complexes taking part in biosynthesis.
An energy efficiency solution based on time series data mining algorithm on elementary school building
Authors: Gong Qiang , Liu Xiaodong , Zeng Ying , Han Shuyan 
Published: February 2022

Abstract
The purpose of this study is to conduct data mining research on the time series energy consumption dataset of primary school buildings. Researches done so far mainly focused on cluster analysis and association analysis. In this article, python language is used as the carrier; Κ-shape algorithm and apriori algorithm are adapted to perform cluster analysis and association analysis on the time series energy consumption data of primary school buildings, from the perspective of the subentry and total energy consumption. The final result shows that the energy consumption curve and association rules obtained through clustering and association can effectively reflect the operating characteristics of primary school buildings. In terms of clustering, regardless of the subentry energy consumption or the total energy consumption, there are different characteristics of energy consumption patterns in winter and summer, which depend on the school schedule. With respect to association rules, there are different chain relationships between itemized total energy consumptions in the primary school building. In particular, heating natural gas consumption and cooling consumption mainly determine the changes in other energy consumption.
Stability of Peaked Solitary Waves for a Class of Cubic Quasilinear Shallow-Water Equations
Authors: Chen Robin Ming , Di Huafei , Liu Yue 
Published: February 2022

AbstractThis paper is concerned with two classes of cubic quasilinear equations, which can be derived as asymptotic models from shallow-water approximation to the 2D incompressible Euler equations. One class of the models has homogeneous cubic nonlinearity and includes the integrable modified Camassa–Holm (mCH) equation and Novikov equation, and the other class encompasses both quadratic and cubic nonlinearities. It is demonstrated here that both these models possess localized peaked solutions. By constructing a Lyapunov function, these peaked waves are shown to be dynamically stable under small perturbations in the natural energy space $H^1$, without restriction on the sign of the momentum density. In particular, for the homogeneous cubic nonlinear model, we are able to further incorporate a higher-order conservation law to conclude orbital stability in $H^1\cap W^{1,4}$. Our analysis is based on a strong use of the conservation laws, the introduction of certain auxiliary functions, and a refined continuity argument.