bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hand Hygiene in the Intensive Care Unit: Knowledge, Compliance and Factors Influencing Nursing Adherence, a Descriptive Study
Authors: Arai Mounir , Feniche Mohammed.EL , Ouhadous Mohammed , Lajane Halima , Barrou Lahoucine , Zerouali Khalid 
Published: August 2022

Background:
Nosocomial infections are particularly common among hospitalized patients who undergo resuscitation compared with other types of care. Hand hygiene remains the simplest and most effective measure to prevent and control the risk of infection.

Objective:
The main objectives are to evaluate hand hygiene compliance among nursing staff in the different intensive care units and to identify the factors influencing the adherence of nursing staff to the practice.

Methods:
It was a quantitative descriptive study using a questionnaire and an observation grid with all the nursing staff working in all the intensive care units of our university hospital.

Results:
The study showed a hand contamination rate of (80%), a hand hygiene compliance rate of (21.3%), it also showed the different factors explaining non-adherence, these are not necessarily related to training, nor to the availability of material resources but related to hidden reasons, non-apparent factors, which are often more important. (Workload and work environment)

Conclusion:
This study examined hand hygiene in the ICU setting, obtained data on overall compliance, which remains poor, and the various factors influencing nurses' adherence to the practice.
Oral Hydroxychloroquine Mitigates Lipopolysaccharide-induced Lung
Injury by Inhibiting Pyroptosis in Mice
Authors: Xiong Rui , Li Ning , Xiong Juan , Liu Bohao , He Ruyuan , Wang Bo , Geng Qing 
Published: August 2022

Background and Objective:
Hydroxychloroquine (HCQ) is a molecule derived from
quinacrine; it displays a wide range of pharmacological properties, including anti-inflammatory,
immunomodulatory, and antineoplastic. However, little is known about this molecule’s role in
lung injury. This study aimed to identify HCQ’s regulatory role of HCQ in sepsis-induced lung injury
and its molecular mechanism. Methods: To test the protective properties of HCQ, we established
an in vivo model of lipopolysaccharide (LPS)-induced lung injury in mice. The extent of the
injury was determined by evaluating histopathology, inflammatory response, oxidative stress, and
apoptosis. Mechanistically, conventional nucleotide-binding oligomerization domain leucine-rich
repeat and pyrin domain-containing 3 (NLRP3) knockout mice were employed to investigate
whether HCQ exerted pulmonary protection by inhibiting NLRP3-mediated pyroptosis.

Results:
Our findings revealed that HCQ pretreatment significantly mitigated LPS-induced lung
injury in mice in terms of histopathology, inflammatory response, oxidative stress, and apoptosis,
while inhibiting LPS-induced NLRP3 inflammasome activation and pyroptosis. Additionally, the
indicators of lung injury, including histopathology, inflammatory response, oxidative stress, and
apoptosis, were still reduced drastically in LPS-treated NLRP3 (-/-) mice after HCQ pretreatment.
Notably, HCQ pretreatment further decreased the levels of pyroptosis indicators, including IL-1β,
IL-18 and Cle-GSDMD, in LPS-treated NLRP3 (-/-) mice.

Conclusion:
Taken together, HCQ protects against lung injury by inhibiting pyroptosis, maybe not
only through the NLRP3 pathway but also through non-NLRP3 pathway; therefore, it may be a
new therapeutic strategy in the treatment of lung injury.
Herbal and Ayurvedic Plants as Remedial Approach for Viral Diseases
with Focus on COVID-19: A Narrative Review
Authors: Kushwah Ajay Singh , Joshi Yashvita , Rani Hema , Kaur Gurpreet , Kumar Manish , Sindhu Rakesh K. , Mittal Roopal 
Published: August 2022

Background:
Infectious diseases have posed a major threat to human survival for centuries and can devastate entire populations. Recently, the global outbreak of COVID-19 has increased exponentially, affecting more than 200 countries and millions of lives since the fall of 2019, largely due to the ineffectiveness of existing antiviral therapies. WHO announced it a public health emergency of international concern. A significant waiting period in antiviral therapy hindered by the rapid evolution of severe acute respiratory syndrome-coronavirus-2 aggravated the situation ensuing imposition of strict laws (e.g., communal dissociation, international travel restrictions, and maintenance of hygiene) that would help in inhibiting further outspread of COVID-19. Ayurveda system of medicine offers a holistic approach to the COVID-19 pandemic.

Objective:
This review aims to highlight the potential of medicinal herbs and Ayurvedic drugs as the remedial approach for viral diseases, such as COVID- 19.

Methods:
We reviewed the literature from journal publication websites and electronic databases, such as Bentham, Science Direct, Pub Med, Scopus, USFDA, etc.

Results:
The drugs used in the traditional system of medicine have the potential to prevent and cure the infected patient. Ayurvedic therapies are known for regulating immunity and rejuvenation properties that behold much promise in the management of COVID-19 disease. Government of India, Ministry of AYUSH recommends some precautionary fitness measures and an increase in immunity with special reference to respiratory health.

Conclusion:
While there is no medication for COVID-19 as of now, taking preventive measures and boosting body immunity is highly recommended. A number of medicinal plants that play an important role in revitalizing the immune system are easily accessible in home remedies.
Anti-cancer Potential of Hypericum spp. with Focus on Hypericum Perforatum:
A Review of the Literature
Authors: Deravi Niloofar , Alavi Dana Seyyed Mohammad Matin , Khoshnazar Maryam , Banyarani Shabnam Paydari , Mokhtari Farzin Sataei , Mohammadie Zahra Eslami , Shamsehkohan Amirreza , Valizadeh Maryam , Ahangar-Sirous Ramin , Rahimi Zahra , Poudineh Mohadeseh 
Published: August 2022

Background and Ams:
Cancer is the cause of many deaths and is the second most prevalent
cause of death worldwide. Besides its high mortality, cancer can cause emotional and economic
burdens on patients and society. Hypericum is known as herbal medicine that has many species. Its anticancer
effects have been proven in various articles. It has many active compounds, including flavonoids,
phloroglucinols, and phenylpropanoids. The current review aimed to collect data on the anticancer
potential of Hypericum on different types of cancer cell lines and their chief mechanisms.

Method:
A search was conducted on PubMed, Scopus, Web of Science, ScienceDirect, ResearchGate,
and Google Scholar databases to find relevant studies on the anti-cancer potential of
Hypericum perforatum and its underlying mechanisms of action in different cancers. The relevant
English language articles published up to March 2022 were collected, screened, and reviewed.

Results:
The anti-cancer effects of Hypericum perforatum were shown against glioblastoma, neuroblastoma,
leukemia, and liver, breast, prostate, lung, bladder, colon, skin, and pancreatic cancers. It
can induce apoptosis by activating caspase enzymes and inhibit cell growth in different cancer cell
lines. Also, the cytotoxic effects of Hypericum perforatum extract on cancer cell lines were shown in
in vitro studies.

Conclusion:
Hypericum perforatum can be proposed as a strong herbal remedy for the treatment of
cancer since it is an available and cheap treatment for cancer compared to other treatments, but further
clinical trial studies should be performed to confirm these properties.
Information Extraction of the Vehicle from High-Resolution Remote Sensing
Image Based on Convolution Neural Network
Authors: Asif Ikbal Mohammad , Wang Yanmei , Peng Fei , Lu Mingyu 
Published: August 2022

Aims:
To effectively detect vehicle targets in remote sensing images, it can be widely
used in traffic management, route planning, and vehicle flow detection. YOLOv3 deep learning
neural network, which mainly studies the vehicle target detection in remote sensing images and
carries out the target detection suitable for the characteristics of remote sensing images.

Objective:
This paper studies the information extraction of vehicle high-resolution remote sensing
images based on a convolution neural network.

Method:
The YOLOv3 network model of vehicle target detection in satellite remote sensing images
is optimized. The iterations are set to 50002000045000, and the learning rate is 0.001. At the
same time, the comparative experiments of RCNN, Fast RCNN, fast RCNN, and yolov3 network
models are carried out.

Result:
The ca-yolov3 network model can be applied to target detection in satellite images. After
40500 times of learning, the loss function value of the model is reduced to about 0.011.

Conclusion:
The IOU value of the model also has a good performance in the training process,
which makes the yolov3 neural network model more accurate in the image small target detection.
Is Breastfeeding Duration Associated with Risk of Developing
ASD?
Authors: Khazaei Salman , Jenabi Ensiyeh , Seyedi Mahdieh , Bashirian Saeid 
Published: August 2022

Background:
There are few studies in the world on the duration of breastfeeding and the risk of autism. To our knowledge, no study has yet explained the association between breastfeeding duration and ASD in Iran.

Aims:
The present study evaluated the association between breastfeeding and the risk of ASD in offspring in the west of Iran.

Methods:
This case-control study was performed on 100 children aged 3-14 years who had a medical record in the Autism Spectrum Disorder Research Center and the Autism Association of Hamadan and were diagnosed with autism according to the Diagnostic and Statistical Manual of mental disorders [DSM-5] criteria. The control group included healthy children who had active family record in comprehensive health service centers. All analyzes were performed using Stata software version 14. The significance level was considered less than 0.05.

Results:
After adjusting for other variables, each increase in the month of breastfeeding was associated with a 5% decrease in odds of ASD [OR=0.95 [95% CI: 0.91, 0.99], P=0.03]. The odds of ASD in boys were significantly higher [OR=3.85 [95% CI: 1.91, 7.76], P<0.001]. Moreover, drug use [OR=0.01], history of autism [OR=6.62], history of psychiatry disorder [OR=7.2] were significantly associated with increased odds of ASD [P<0.05].

Conclusion:
These findings showed that breastfeeding duration can be a protective factor for ASD. Therefore, policymakers and health staff can reduce the risk of autism by promoting increased breastfeeding duration, especially for children with high risk for autism.
Associations Between Adolescent Problematic Internet Use and Relationship Problems in Chinese Families: Findings from a Large-scale Survey
Authors: Hayixibayi Alimila , Strodl Esben , Chen Wei-Qing , Kelly Adrian B 
Published: August 2022

Background
Problematic internet use (PIU) is prevalent among Chinese adolescents. There is a need to better understand how the quality of parent-adolescent relationship is associated with adolescent PIU to guide the development of effective prevention and early intervention programs.

Objective
This study aims to evaluate parent-adolescent conflict and parenting styles as potential risk factors associated with adolescent PIU.

Methods
A sample of 6552 students (aged 10-19 years) from 22 schools in Guangdong, China, was recruited. The participants completed self-report questionnaires measuring their perceptions of conflict with their parents (involving verbal conflict, emotional abuse, and physical abuse) as well as their perceptions of their parents’ parenting styles (including parental care and parental control as measured by the Parental Bonding Inventory), and PIU using the Adolescent Pathological Internet Use Scale. Grade level and gender were examined as moderators of these associations.

Results
Using multiple regression analyses, we found that greater mother-adolescent conflict, father-adolescent conflict, and parental control, and lower levels of parental care, were associated with higher levels of adolescent PIU (P<.001). The association between mother-adolescent conflict and PIU was stronger in older students than in younger students (P=.04), whereas the association between father-adolescent conflict and PIU was stronger in male students than in female students (P=.02). Compared with those who reported no mother-adolescent conflict, participants who experienced verbal conflict and emotional abuse, but not physical abuse from their mothers, reported higher levels of PIU (P<.001). Compared with those who reported no father-adolescent conflict, participants who experienced verbal conflict, emotional abuse, and physical abuse from their fathers had significantly higher levels of PIU (P<.001, P<.001, and P=.02, respectively).

Conclusions
These findings point to the value of interventions to reduce parental verbal conflict, emotional abuse, and physical abuse, and to increase positive parenting styles, to lower the risk of PIU in Chinese adolescents.
Video Consultations in General Practice: Tendencies and Lessons Learned From the First COVID-19 Lockdown Period
Authors: Assing Hvidt Elisabeth , Grønning Anette , Lüchau Elle , Nordtug Maja , Bavngaard Martin , Søndergaard Jens 
Published: August 2022

Background
Video consultation was urgently introduced in general practice in connection with the COVID-19 pandemic, where a rapid implementation ensured patients’ continued access to their general practitioner (GP). With the Danish lockdown in March 2020, the use of video consultations in general practice increased drastically and then declined significantly shortly after as society gradually reopened. Today, only a small proportion of the total number of consultations in general practice is made up of video consultations, and there is great variation in the scope and use of video consultation among GPs and practice staff.

Objective
The aim of this paper is to present research findings from a qualitative, interdisciplinary project, investigating GP and patient experiences with video consultations during the first lockdown period in 2020, which might help explain the abovementioned tendencies in relation to scope and implementation variances.

Methods
The data corpus includes data generated through semistructured interviews with 27 patients and 15 GPs, as well as 8 video recordings of video consultations between GP and patient.

Results
The patients reported positive experiences with consulting their GP through video, valuing increased convenience and spatial flexibility and wishing for future use of video consultation as either a supplement or an alternative to physical consultation. Video consultation furthermore presented a new communicative context in which both patients and GPs enacted distinct forms of technologically facilitated participation.

Conclusions
To further the best use of video consultation in future general practice, organizational and individual factors such as renumeration, task delegation, time pressure, and professional identity need to be considered.
R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 9
Authors: Simpson Alex , Ramagopalan Sreeram V 
Published: August 2022

In this latest update we highlight a recent International Society of Pharmacoeconomics and Outcomes Research Good Practice Report on machine learning (ML) for health economics and outcomes research. We specifically discuss use cases of ML that offer opportunities in the generation of evidence using real-world data, including improvements in the identification of study cohorts, confounder identification and adjustment and estimating treatment effect heterogeneity. Barriers to the wider adoption of ML methods are also discussed.
Un archivo “por entregas”: la Revista del Río de la Plata y la conservación de la memoria americana (1871-1877)
Authors: Arenas Deleón Nicolás 
Published: August 2022

Este artículo examina las características del proceso de elaboración y circulación de la Revista del Río de la Plata, periódico publicado en Buenos Aires por los intelectuales Juan María Gutiérrez, Vicente Fidel López y Andrés Lamas. Mediante el análisis del soporte y de la correspondencia intercambiada entre sus responsables, se busca determinar su lugar particular dentro del espacio publicitario argentino durante la década de 1870 y demostrar la forma en que accionó en el campo editorial como plataforma eficaz para salvaguardar (reunir y visibilizar) el acervo documental del continente —en tensión y diálogo con otros proyectos privados y estatales— y como espacio coleccionista y bibliófilo alrededor del cual se conformó un extenso entramado colaborativo transnacional que facilitó la creación y reescritura de distintos relatos histórico-literarios sobre el pasado argentino y americano por parte de las élites letradas.
As ferramentas de aprendizagem preferidas da geração Z do curso técnico em Administração de um instituto federal: o contexto da disciplina de Logística
Authors: Santos Moreira Sérgio Adriany 
Published: August 2022

Esta pesquisa teve o objetivo de analisar a percepção de jovens, futuros ingressantes no mercado de trabalho e pertencentes à geração Z, sobre a disciplina de Logística e as ferramentas de aprendizagem utilizadas por eles. Foram realizados estudos em artigos científicos que abarcaram a geração Z e o mercado de trabalho; a disciplina de Logística no ambiente escolar; e as ferramentas de aprendizagem. Utilizou-se um questionário prévio na condução da pesquisa com os alunos do curso técnico em Administração de um Instituto Federal em relação à disciplina de Logística. Por meio da análise de dados de 278 estudantes respondentes da pesquisa, pôde-se observar grande expectativa da geração Z em utilizar ferramentas tecnológicas em seu processo de ensino-aprendizagem e participar de visitas técnicas para aproximar a teoria da prática do mercado de trabalho. Por conseguinte, foi inferido que o ingresso efetivo dos estudantes da geração Z no mercado pode estar ligado ao aprendizado mais prático em sala de aula e às habilidades e competências específicas desse grupo geracional.
Historical origins of the establishment of the institute of commercial mediation in the sphere of economic activity
Authors: Zaborovskyy V.V. , Manzyuk V.V. , Vashkovich V.V. 
Published: August 2022

This article reveals the basics of the institution of commercial intermediation. The evolution of various forms of existence of this economic and legal institution is studied. The transformation of the activity of commercial intermediaries from ancient times to the middle of the twentieth century is analyzed.
To achieve this goal, the author analyzed the works of famous historians, lexicographers and social researchers. Based on this, it was concluded that trade intermediation as such arose immediately with the exchange of goods and provided, first of all, the interests of the country.
Powerful states, which focused on market turnover and economic growth, put under government regulation such activities as trade intermediation. And at the turn of the seventeenth and eighteenth centuries, the social importance of this activity is growing significantly, as evidenced by the establishment of requirements for such a profession, and bringing its representatives to the state.
The issue of automation of part of the function of this profession is being raised, in particular with the help of smart contracts (B2B) and chatbots (B2C).
The study provides an opportunity to conclude that commercial mediation in its various manifestations has existed since ancient times, and the profession itself was respected and influential in all societies. After all, the commercial world and the needs of the world market only attract the growth of this type of economic activity, leading to the gradation of its varieties and forms.
Administrative responsibility for offenses in the field of subsoil use: theoretical and legal aspect
Authors: Machuska I.B. 
Published: August 2022

The article is devoted to the study of theoretical problems related to the application of measures of administrative liability for offenses in the field of subsoil use.
In the article the author emphasizes that in the field of subsoil use there is a significant range of problems, one of which is the unauthorized extraction of minerals, which causes irreparable damage to the environment. The author analyzes a significant range of offenses related to the illegal extraction of minerals (coal, amber) in Donetsk, Luhansk and Rivne regions.
It is noted that ensuring legality in the field of subsoil use requires ensuring an effective mechanism of state coercion with the application of administrative liability for the rational use of subsoil.
It is established that relations in the field of subsoil use are complex, both from the standpoint of legal content and from the standpoint of their role and place in the system of public relations, which necessitates a particularly balanced state policy in the field of subsoil protection and management.
In the article the author emphasizes that the institute of administrative responsibility plays a special role in the state regulation of protection of relations in the field of subsoil use and is one of the effective means used for violations of subsoil legislation.
It is noted that the institute of administrative responsibility in the field of subsoil use has significant shortcomings, both in terms of building the rules and in terms of the content of sanctions.
It is proved that the content of the relevant articles of the Code of Ukraine on Administrative Offenses does not contain all the necessary provisions on administrative liability for offenses in the field of subsoil use, namely: illegal mining and subsoil protection measures.