bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of a Pair Density Wave State in UTe2
Authors: Gu Qiangqiang , Carroll Joseph , Wang Shuqiu , Ran Sheng , Broyles Christopher , Siddiquee Hasan , Butch Nicholas , Saha Shanta , Paglione Johnpierre , Davis JC Seamus , Liu Xiaolong 
Published: September 2022

Abstract
Although UTe2 is a very promising candidate material to embody bulk topological superconductivity, its superconductive order-parameter ∆(k) remains unknown. Many diverse forms for ∆(k) are physically possible because, in uranium-based heavy fermion materials, strongly hybridized flat bands of composite fermions generate highly complex interactions. Moreover, in such materials intertwined density waves of spin (SDW), charge (CDW) and pairs (PDW) may interpose, with the latter state exhibiting spatially modulating, superconductive order-parameter ∆(r), electron pair density and pairing energy gap. Hence, the newly discovered CDW state in UTe2 motivates the exciting prospect that a PDW state may exist in this material. To search for a PDW in UTe2, we visualize the pairing energy-gap with μV-scale energy-resolution made possible by superconductive STM tips at subkelvin temperatures. We detect three PDWs, each with peak-peak gap modulations circa 10 μeV and at incommensurate wavevectors P_(i=1,2,3) that are indistinguishable from the wavevectors Q_(i=1,2,3) of the prevenient CDW. Concurrent visualization of the UTe2 superconductive PDWs and the non-superconductive CDWs reveals that every Pi: Qi pair is registered to each other spatially, but with a relative phase δϕ≈π. From these observations, and given UTe2 as a spin-triplet superconductor, the PDW state detected here should be a spin-triplet pair density wave. While such states do exist in superfluid 3He, for superconductors they are unprecedented.
From Waste to Wealth: A Cellulose-based Fibrous Membrane from Recycled Cigarettes Supported with Dual Perovskite for Formaldehyde Degradation at Room Temperature
Authors: Duan Anyang , Wang Tian , Wu Shuanglin , Ji Chenhao , Ma Qiyao , Huang Fenglin 
Published: September 2022

Abstract
Formaldehyde, as a hazardous indoor contaminant following house decoration, is essential to its efficient removal at room temperature. This paper reports an eco-friendly approach for extracting cellulose acetate (CA) from waste cigarette filters to construct a nanofibrous composite membrane for formaldehyde degradation at ambient temperature. A composite nanofibrous membrane was fabricated by salable electrospinning of cellulose acetate and La2CoMnO6/CeO2(LC), followed by hydrolysis and potassium doping with KOH. The membrane demonstrates excellent catalytic activity (97.56 % of conversion), super stability (95.35 % of conversion after 50 h) and long service life (93.96 % of conversion after 3 catalysis cycles), which is ascribed to the synergistic catalytic effect of double perovskite and rapid hygroscopic properties of cellulose. In addition, the obtained membrane has a higher moisture regain (7.82 %) than that of the LC/CA nanofibrous membrane (2.21 %), and higher than that of the commercial air filter membrane using polypropylene (PP) fiber (near zero), accelerating formaldehyde adsorption and fastening the water removal, thereby allowing for the long-term positive progress of formaldehyde catalytic oxidation reaction. This work provides encouraging guidance for further exploration into formaldehyde degradation, which is promising for application in air cleaning.
Short-Course Empiric Antibiotic Therapy for Possible Early-Onset Sepsis in the NICU
Authors: Sanchez Pablo , Prusakov Pavel , Romero Concepcion de Alba , Zamora-Flores Elena , Escamilla María Reyes , White Natalie , Miller Randy , Moraille Richard , Thiele Anthony , Magers Jacqueline 
Published: September 2022

Abstract
Objective. On 2/2019, the Neonatal Antimicrobial Stewardship Program at Nationwide Children’s Hospital recommended reducing empirical antibiotic therapy for early-onset sepsis (EOS) from 48 to 24 hours with a TIME-OUT. We describe our experience with this guideline and assess its safety.
Methods. Retrospective review of all newborns evaluated for possible EOS at <72 hours of age at 6 neonatal intensive care units from 12/2018-7/2019. Safety endpoints were re-initiation of antibiotics within 7 days after discontinuation of the initial course, positive bacterial blood or cerebrospinal fluid culture in the 7 days after antibiotic discontinuation, and overall and sepsis-related mortality.
Result. Among 414 newborns evaluated for EOS, 196 (47%) received a 24 hour rule-out sepsis antibiotic course while 218 (53%) were managed with a 48 hour course. Infants in the two groups did not differ in the predefined safety endpoints.
Conclusion. Antibiotic therapy for suspected EOS may be discontinued safely within 24 hours.
Innovation and Commercialization in Pandemic Times: a Case Study From Sultanate of Oman
Authors: Hussain Shaik Asif. , Hakro Ahmed Nawaz 
Published: September 2022

Abstract
COVID-19 health-related global urgency has witnessed a substantive impact on research and innovation activities. The uncertain situations have completed the governments and higher education institutions to change and adjust their work environment, but it also affected the research, teaching, and innovation development activities in Higher Education Institutions (HEI). The pandemic situation has posed few challenges and provided ample opportunities to reflect on the way the usual business is being conducted. It provides interesting experiences and novel mechanisms to adopt suitable mechanisms to adjust to the new normal and a few lessons learned to be better equipped to face such realities in the future. This paper aims to share the experience of one such situation in a pandemic as how the challenges and responses faced in one such situation at the institutional level during the pandemic and deliberated some interesting lessons learned to further formulate the strategic response to carry out planned innovation activities. The lessons learned are insightful for future practices to support in the areas of social innovation, technology transfer, and entrepreneurship activities. The reflective account of case study responses collected from faculty and students' insights provides rich and diverse experiences that contextualize the achievements and mitigating effects. Furthermore, witnessing awareness, marketing, knowledge transfer, dissemination, and commercialization of innovation activities conducted during these testing times. The shared experiences are summarized in detail and diverse backgrounds are upheaved at the Technology Transfer Office (TTO) of the case study. The lessons learned in adjusting to the new remote learning environment provide an interesting account of innovation activities. The findings suggest that a strong, focused approach with a professional commitment to the strategic direction of the institution makes relative success in achieving the objectives of the commercial office. The efficient management of commercial 0perations during and after COVID-19 to witness the real-time collaboration between researchers across the globe. The findings may be taken in careful application in other similar situations.
Precise co-delivery of drug and cytotoxic exosomes using a biomimetic nanorobot for glioma regression and recurrence prevention
Authors: Hao Wenyan , Li Peiying , Li Chuntong , Fan Yueyue , Li Chen , Chen Mengyu , Liu Qianqian , Yang Meiyan , Chen Mengli , Gao Chunsheng , Yang Yang 
Published: September 2022

AbstractBackgroundAn increasing number of research studies have demonstrated the superiority of NK cells in clinical applications for cancer therapy. For a long time, the brain was considered as restricted area for immune cells because of the BBB, making the efficacy of NK cell-based immunotherapy on glioma is still insufficient. Therefore, a strategy to overcome the therapeutic bottlenecks of NK cell therapy for brain disease are urgently needed.In this study, we designed a biomimetic nanorobot termed “DTX@aNK Exos-NM” for enhancing the targeting ability and antitumor capacity. DTX@aNK Exos-NM was predesigned to have enhanced BBB penetration characterization and precise residual tumor targeting ability for delivery of both chemotherapeutic drugs and cytotoxic NK cell exosomes.ResultsThe biomimetic nanorobot was successfully established with both NK cell-liked and neutrophil-liked properties, as well as high loading efficiency and encapsulation efficiency of cytotoxic exosomes and chemotherapy drug. The transwell BBB model and C6-Luc glioma model in vivo study showed that DTX@aNK Exos-NM could penetrate the BBB and migrate to the residual tumor area efficiently in response to the inflammatory factors and Hsp70. In addition, DTX@aNK Exos-NM could effectively inhibit tumor proliferation and prolong survival time in a glioma mouse model.ConclusionOur results indicate that the the well-designed DTX@aNK Exos-NM not only enhances the antitumor effect of NK cells but also efficiently promoting cellular uptake of cytotoxic exosomes and DTX by endothelial cells and tumor cells. The co-delivery of chemotherapeutic drugs and cytotoxic exosomes could slow the recurrence of residual tumor growth and significantly improves survival. This personalized both drugs and exosomes delivery platform responsive to post-radiotherapy microenvironment may provide a new opportunity for cancer treatment.
Attribution of Wintertime Extreme Rainfall over the Pearl River Delta to Anthropogenic Influences
Authors: Zhao Rui , Tam Chi-Yung Francis , Lee Sai Ming 
Published: September 2022

Abstract
During 14 to 17 December 2013, the Pearl River Delta (PRD) in South China received its largest wintertime 4-day precipitation of above 100 mm since 1998, due to strong cold air intrusion. Here we investigate the extent to which such extreme rainfall can be attributed to human activities, by carrying out Weather Research and Forecasting (WRF) model multi-physics integrations at a convection-permitting resolution. The factual WRF runs were conducted using the European Centre for Medium-Range Weather Forecasts (ECMWF) Reanalysis (ERA)-Interim as boundary and initial conditions, and the counterfactual runs by the same ERA-Interim forcing with human influences removed. The latter was deduced by subtracting the Coupled Model Intercomparison Project Phase 5 (CMIP5) historical-natural from the historical run outputs. Results show that human-induced thermodynamic (TH) forcing alone accounts for ~9% increase in the 4-day mean rainfall for 1.2 K near-surface warming, whereas combined dynamic (DY) and TH (“DY+TH”) forcing contributes to ~14% increase for 2 K warming (nearly CC rates). However, TH and DY+TH forcing can intensify the 95th percentile daily rainfall by ~13% and ~19%, respectively. This suggests that human-caused DY forcing can further exacerbate the TH-driven rainfall enhancement. Indeed, under the combined TH and DY effects, there is stronger land-sea thermal contrast with anomalous low-level southerly wind and convergence in coastal South China. The frontal system and ascending motion are therefore intensified, resulting in even stronger rain rates than TH-only forcing. Moisture budget analysis reveals that the DY component accounts for most of the 95th percentile rainfall changes while the TH contribution is negligible. Our findings highlight the salient role of dynamic effects on intensifying PRD’s extreme rainfall in wintertime.
Twitter Data Analysis using Distill BERT and Graph Based Convolution Neural Network during Disaster
Authors: Danday Anusha , Murthy T Satyanarayana 
Published: September 2022

Abstract
TDS (Twitter Data Analysis) in Social media plays an essential role in spreading information during disasters and needy situations. May it be for seeking help or sharing and updating seriousness of situation or communicating the status or response to public in need social media plays a major role in case of emergencies. This research focuses on to prepare the data by performing cleansing and various transformations, to generate word embedding vectors using DistillBERT and generate a similarity matrix , to construct the(Graph based Convolution Network) GCN model to classify text sequences, to analyze the performance of the DistillBERT with GCN model in Text classification. To implement this, contextual word embedding’s introduced for generating word vectors. The contextual word embedding’s and concept of graph neural networks which has gained its importance to capture contextual relationship among the text which further improves the performance of classification. In this work proposed a semi supervised ML model to detect and classify Need and Availability of Resources tweets with accuracy of 98% as compared with state-of-the-art approaches.
Does the shape of the copper intrauterine device play a role in expulsion? Results from the ongoing European Active Surveillance Study on LCS12
Authors: Boehnke Tanja , Bauerfeind Anja , Eggebrecht Lisa , Cellier Camille , Lange Jens A. , Heinemann Klaas , Madden Tessa 
Published: September 2022

Abstract
Purpose: To compare the incidence of partial and complete expulsion for different copper intrauterine device (IUD) shapes.
Materials and methods: A secondary analysis of the ongoing, prospective, non-interventional European Active Surveillance Study on LCS12 - an IUD with a total amount of 13.5 mg levonorgestrel (EURAS-LCS12). Women with newly inserted IUDs were recruited in 10 European countries (Austria, Germany, Poland, Czech Republic, Spain, Italy, United Kingdom, France, Sweden, and Finland) via a network of approximately 1,200 health care professionals. We calculated the cumulative incidence, crude and adjusted hazard ratios for expulsion.
Results: For this analysis, 27,822 copper IUD users from the EURAS-LCS12 study were considered. The most frequently used IUD shape was T or Y (73.7%), followed by chains (12.1%), Omega (10.5%), and balls (3.8%). Cox regression analysis regarding partial expulsions yielded an adjusted hazard ratio (HRadj) of 1.8 (95% CI, 1.3-2.4), 0.2 (95% CI, 0.2-0.4), and 2.9 (95% CI, 2.1-3.9) for Omega-shape, chain, and ball versus T/Y-shape, respectively. For complete expulsions, HRadj was 0.5 (95% CI, 0.3-0.8), 1.7 (95% CI, 1.3-2.3) and 2.9 (95% CI, 2.0-4.2) for Omega-shape, chain and ball versus T/Y-shape, respectively.
Conclusion: The shape of the copper IUD is associated with the risk of device expulsion and thus, should be considered at the time of contraceptive counseling.
Properties and mechanism of two-way shape memory polyurethane composite under stress-free condition
Authors: Yang Haowen , Shi Ruixin , Jiang Qinglong , Ren Juanna 
Published: September 2022

Abstract

Two-way shape memory polymer can exhibit reversible shape transformation, which shows great application potential as a smart material. It is necessary to develop new reversible shape memory composite systems to achieve accurate and wide-range control of two-way shape memory behavior, especially under the condition of no external force. A chemically cross-linked two-component crystalline block copolymer was prepared based on the independence of crystallization of PLA and PCL. The mechanism of two-way shape memory behavior under stress-free condition of the material is revealed. The results show that both the crystallization and thermal property of PLA/PCL-PU can be significantly changed by adjusting the proportion between PLA and PCL, and the dosage of crosslinking agent, and thus the shape memory property of PLA/PCL-PU can be regulated accordingly. The two-way shape recovery rate of the material can reach to 41.11%. This work provides a facile strategy to fabricate a biodegradable thermally induced two-way shape memory material under the stress-free condition with tunable shape memory properties.
Being poor and being NEET in Europe: Are these two sides of the same coin?
Authors: Mussida Chiara , Sciulli Dario 
Published: September 2022

Abstract
We implement a dynamic bivariate probit model to explore the possible relation between at-risk-of-poverty and NEET (Not in Employment, Education or Training) in 21 European countries using 2016–2019 European Union Statistics on Income and Living Conditions panel data. We identify genuine state dependence and account for possible feedback effects from past poverty to the NEET status. We also consider two alternative definitions of NEET, i.e. unemployed and inactive NEET and inactive NEET only. We find that both poverty and NEET are characterized by significant genuine state dependence. We also observe a vicious circle between the phenomena, especially when adopting the definition that includes unemployed and inactive NEETs. This suggests a leading role of unemployment in the detrimental effect of being NEET on poverty. We also offer supplementary analyses and further insights on country heterogeneity by looking at the role of social protection expenditure.
Mitochondrial connexin43 and mitochondrial KATP channels modulate triggered arrhythmias in mouse ventricular muscle
Authors: Sato Haruka , Nishiyama Masami , Morita Natsuki , Satoh Wakako , Hasegawa Taiki , Someya Yuka , Okumura Tsuyoshi , Koyama Sana , Shindoh Chiyohiko , Miura Masahito 
Published: September 2022

Abstract
Aim: Connexin43 (Cx43) exits as hemichannels in the inner mitochondrial membrane. We examined how mitochondrial Cx43 and mitochondrial KATP channels affect the occurrence of triggered arrhythmias.
Methods and Results: To generate cardiac-specific Cx43-deficient (cCx43-/-) mice, Cx43flox/flox mice were crossed with α-MHC (Myh6)-cre+/- mice. The resulting offspring, Cx43flox/flox/ Myh6-cre+/- mice (cCx43-/- mice) and their littermates (cCx43+/+ mice), were used. Trabeculae were dissected from right ventricles of mouse hearts. Cardiomyocytes were enzymatically isolated from ventricles of mouse hearts. Force was measured with a strain gauge in trabeculae (22°C). To assess arrhythmia susceptibility, the minimal extracellular Ca2+ concentration ([Ca2+]o,min), at which arrhythmias were induced by electrical stimulation, was determined in trabeculae. ROS production was estimated with 2’,7’-dichlorofluorescein (DCF), mitochondrial membrane potential with tetramethylrhodamine methylester(TMRM), and Ca2+ spark frequency with fluo-4 and confocal microscopy in cardiomyocytes. Mitochondrial Ca2+ was estimated with rhod-2 in trabeculae. Diazoxide was used to open mitochondrial KATP. Most of cCx43-/-mice died suddenly within 8 weeks. Cx43 was present in the inner mitochondrial membrane in cCx43+/+mice, but not in cCx43-/-mice. In cCx43-/- mice, the [Ca2+]o,min was lower, Ca2+ spark frequency and DCF oxidation rate were more increased, and TMRM fluorescence was more decreased. These changes in cCx43-/-mice were suppressed by diazoxide. Besides, in cCx43-/- mice, antioxidant peptide SS-31 increased the [Ca2+]o,min. Rhod-2 fluorescence was increased at high [Ca2+]o only in Cx43-/- mice.
Conclusions: These results suggest that the deficiency of Cx43 activates Ca2+ leak from the SR probably due to an increase in ROS production, depolarization of mitochondrial membrane potential, and an increase in mitochondrial Ca2+, thereby causing triggered arrhythmias and that the deficiency of Cx43 hemichannels may be compensated by activation of mitochondrial KATP channels in mouse hearts.
Robotic Bilateral Nephrectomy for Large Polycystic Kidney Disease
Authors: Masterson John M. , Zhao Hanson , Taich Lior , Naser-Tavakolian Aurash , Johnson Hayley , Najjar Reiad , Kim Irene K. , Gupta Amit 
Published: September 2022

Abstract
Objective
To describe our technique and review our experience with synchronous robotic bilateral nephrectomy for large kidneys in ADPKD with the Da Vinci XI and Da Vinci Single Port platforms (Intuitive Surgical, Sunnyvale, CA).
Materials and Methods
We performed a retrospective review of all robotic bilateral nephrectomy cases from January 2020 to October 2021 at a high-volume robotic single center. Demographic data and perioperative details including preoperative CT scans, indication for nephrectomy, and renal function were collected. We also collected post-op course data and final specimen data details.
Results
Eleven cases were included. Patient demographics, indications for surgery, and specimen data are outlined in table 1. The largest kidney removed measured 32 cm in largest dimension on preoperative imaging. Median operating time from incision to closure was 299 minutes (IQR 260, 339). Median estimated blood loss was 100cc (IQR 50, 175). Two patients were transfused intraoperatively. Median pre- and post-operative Hgb was 11.3 and 9.7 respectively. Median length of stay was 3 days (IQR 2, 3.5). There were no intraoperative complications and no open conversions. Post-operative complications included one incisional hematoma, and one superficial wound infection. One patient was admitted to the surgical ICU post operatively for ventilatory support. Two patients were readmitted within 30 days of surgery.
Conclusion
The robotic approach to bilateral native nephrectomy for ADPKD should be considered when native nephrectomies are indicated. The operative times and outcomes compare favorably to prior series and this technique works even for very large kidneys.
A novel circulating RNA circELMOD3 functions as a tumor suppressor in hepatocellular carcinoma through TRIM13/P53 signal axis
Authors: Lai Mingshuang , zeng xiao yun , Liu Meiliang , Li Deyuan , Zhang Ruirui , Wang Lijun , Li Xiaofei , Chen Sixian , Wu Siqian , Xiao Suyang , Wei Liling , Wang Xiaogang , Nan Aruo 
Published: September 2022

Abstract
Background
Circular RNAs (circRNAs) have been identified as key regulatory factors in tumor development based on accumulating studies. However, the underlying molecular mechanisms of the circulating circRNAs in hepatocellular carcinoma (HCC) haven't t been fully elucidated.
Methods
Five pairs of HCC and adjacent normal tissues were processed using RNA-sequencing to determine the differential expressed circRNAs. The expression levels of genes and proteins were detected by qPCR and Western blotting, respectively. CCK-8, EdU, Flow cytometry, wound healing assay, Transwell assays, and xenograft mouse model were performed to investigate the biological function of circELMOD3 both in vitro and in vivo. Fluorescence in situ hybridization (FISH), RNA antisense purification (RAP) and dual luciferase reporter assay were carried out to verify the interaction between circELMOD3, miR-6864-5P and TRIM13.
Results
CircELMOD3 was downregulated in plasma and tissues from HCC patients and was related to their clinicopathological characteristics. Significantly, plasma circELMOD3 was shown to be a highly sensitive and non-invasive biomarker to distinguish HCC from healthy controls (AUC = 0.908). Functionally, circELMOD3 prevented HCC cells from proliferating and caused them to undergo apoptosis both in vitro and in vivo. Mechanistically, circELMOD3 increased the expression of TRIM13 by acting as a sponge for miR-6864-5P. In addition, overexpression of circELMOD3 lead to enhanced stability and higher expression level of TRIM13 mRNA, to which it directly binds, and in turn activated the P53 signaling pathway.
Conclusion
CircELMOD3 plays a tumor suppressor role in HCC via TRIM13/P53 signaling axis, which can serve as a potential target for early diagnosis and treatment of HCC patient.
Variational Iteration Method for 2D Hyperbolic Quasi-linear Pde
Authors: Sahu Subrata Kumar , Derkee Simon 
Published: September 2022

Abstract
In this paper, we have constructed two dimensional (2D ) hyperbolic quasi-linear partial differential equations (HQLPDE) by considering two cases. The Cauchy data is given in the form of exponential curve in the 1st case. The initial value problems (IVP) are mentioned as sin x in the 2nd case where as all the cases are associated with time. We have obtained the solutions by using variational iteration method (VIM). In the both cases, we found that solution represents flat surface during the initial stage. We have observed exponential surface in the 1st case and the curved surface in the 2nd case subject to the increasing values of x and y.
Mathematics subject classification: 35Lxx, 35L04