bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Sinusoidal Vision Trifocal Intraocular Lens(IOL) with Monofocal Extended Depth of Focus (EDOF) IOL After Cataract Surgery
Authors: Arslan Mahmut erkam , DURU Necati 
Published: March 2022

Abstract
Purpose: To evaluate and compare the clinical results of sinusoidal vision trifocal intraocular lens (IOL) (AcrivaUD Trinova) and monofocal extended depth of focus (EDOF) IOL (Tecnis Eyhance ICB00) Methods: This study included 98 eyes of 65 patients implanted with sinusoidal vision trifocal IOL and 79 eyes of 53 patients implanted with monofocal EDOF IOL. The following were evaluated; Uncorrected distance(UDVA), intermediate (UIVA), near visual acuity (UNVA), corrected distance(CDVA), intermediate(CIVA) , near visual acuity (CNVA), halo, glare, ocular aberrations, contrast sensitivity. In addition, The National Eye Institute 25-Item Visual Function Questionnaire (NEI-VFQ 25) results of patients were analysed.Results: Three months postoperatively, there were no differences between the groups in terms of UDVA and UIVA(respectively, p=0.780 and p=0.317). Near vision was found to be better for the Trinova group than for the Eyhance group(p<0.001). Trinova IOL provided better contrast sensitivity at all spatial frequencies than Eyhance IOL (p<0,001). Halo perception was reported for only six eyes, all of which were in the Trinova group (6.9%). Glare perception was found to be more common in the Trinova group (15 eyes(17.2%)), than in the Eyhance group(four eyes(5.3%)). With regard to the composite score of NEI-VFQ 25, no significant difference was found between the groups. In the analyses of subgroups, the near activities score was higher in the Trinova group, but distance activities and driving scores were higher in the Eyhance group (p=0.201).Conclusion: Both lenses have been shown to have satisfactory levels of distance and intermediate vision, with high levels of patient satisfaction.
Development and validation of a predictive model to identify the established labor
Authors: Fumagalli Simona , Antolini Laura , Cosmai Greta , Gramegna Teresa , Nespoli Antonella , Pedranzini Astrid , Colciago Elisabetta , Valsecchi Maria Grazia , Vergani Patrizia , Locatelli Anna 
Published: March 2022

Abstract
BackgroundThe diagnosis of the established labor is a crucial clinical decision, and it requires an accurate midwifery assessment. Regular uterine contractions and a cervical dilatation of 4-6 cm are commonly considered to diagnose active labor with a lack of knowledge regarding the role of maternal signs. This study aimed to build and to validate a predictive model based on maternal signs and symptoms to identify a cervical dilatation ³4 . MethodsA prospective observational study was conducted from May to September 2018 in a II Level Maternity Unit (development data), and from May to September 2019 in a I Level Maternity Unit (validation data). Singleton, at term pregnant women with cephalic presentation and presence of uterine activity were enrolled consecutively at the maternity triage or at the antenatal ward during the initial assessment to diagnose the stage of labor. Women <18 years old, with language barrier and induction of labor were excluded. During the assessment midwife observed features of contractions (rhythm, frequency and duration) and 8 specific maternal signs. A nomogram for the calculation of the predictions of cervical dilatation ³ 4 on the ground of 11 maternal signs and symptoms was obtained from a multivariate logistic regression model. The model predictive performance was investigated by internal and external validation. Results288 assessments were analyzed (216 for development data). In the final logistic regression model “Rhythm” (OR 6.26), “Duration” (OR 8.15) of contractions and “show” (OR 4.29) had a significant impact on increasing the probability of a cervical dilatation ³ 4 cm. The area under the ROC curve in the model with only uterine activity was 0.865 (development data) and 0.927 (validation data), with an increment to 0.905 and 0.956, respectively when adding maternal signs. ConclusionOur predictive model based on maternal signs and symptoms has a good performance and could be useful in clinical practice. This may improve the quality of midwifery care, avoiding medicalization, aiming to promote a positive experience of childbirth.
Patient care via video consultations: piloting and S.W.O.T. analysis of a family medicine digitally synchronous seminar for medical students
Authors: Särchen Franziska , Springborn Susanne , Mortsiefer Achim , Ehlers Jan 
Published: March 2022

Abstract
Background: Video consultations can complement primary care patient care, but they can also pose challenges for the physicians involved. A need exists to familiarize medical students with the specifics of video consultations. This paper presents the concept and testing of a digitally synchronous distance seminar in which medical students practice and work through the performance of video consultations as an aid to family physicians activity in a patient-oriented manner. The aim of the evaluation was to analyze the strengths, weaknesses, opportunities, and threats (S.W.O.T.) of the teaching concept.Methods:Within the seminar, 12 students carried out video consultations independently under medical supervision, observed the conversations of their fellow students and processed the experiences in the group. The seminar consisted of two elements: A) The whole group of students and teachers was video consulted in a family practice. B) A small group performed a videoconsultation with connection to the home environment of a patient.The evaluation by the students was done by two questionnaires (pre/post), which were analyzed with descriptive statistics and qualitative content analysis. The S.W.O.T. analysis was elaborated by the author team based on the results of the questionnaires and interviews with the teachers.Results:The students learned the limits and possibilities of teleconsultations and deepened their family medical knowledge. The pilot project has strengthened the interest in video consultations among many participants. Patient contact and focused work were seen as strengths of the tested learning model. Above all, technical difficulties and the time required were mentioned as weaknesses. The seminar should also be held after the COVID-19 pandemic. It would bring the chance to involve especially students with multiple workloads in patient teaching. The risks lie in the fact that it still has to be integrated into the curriculum and there are few personnel resources for the organization.Conclusions:The learning model familiarizes medical students with competences in family medical patient care using video communication. Various strengths, weaknesses, opportunities and threads of the learning concept can be weighted differently. Hereby, project groups can decide individually if they want to integrate the learning concept in their curriculum and which further improvements are necessary.
Effect of Nitrogen Functional Groups on Competitive Adsorption Between Toluene and Water Vapor Onto Activated Carbon
Authors: Li Jinjin , Cheng Tangying , Ma Xiuwei , Hou xueyan , Wu Hao , Yang Linjun 
Published: March 2022

Abstract
To elucidate the effect of nitrogen functional groups on toluene adsorption under humid conditions, a series of N-doped resorcinol-formaldehyde resin-based activated carbons (HNRCs) using g-C3N4 as the nitrogen source were prepared, which possessed different N contents (1.29–6.14%) and similar O contents, named HRC, HNRC1, HNRC3 and HNRC5, respectively. In this study, breakthrough experiments of toluene were conducted and the results showed that under RH50%, the saturated adsorption capacity towards toluene agreed with the BET surface area and micropore volume. Nevertheless, the normalized adsorption capacity of samples was consistent with N content. Moreover, the adsorption isotherms of toluene and water vapor were analyzed, displaying that nitrogen functional groups can not only contribute to the adsorption of toluene but also improve the hydrophobicity of carbon surface, especially graphitic N. Temperature programmed desorption experiments and density functional theory (DFT) calculations further demonstrated that the introduction of N can help to enhance the competitive adsorption of toluene from water vapor. This is because the N functional groups can enhance the π-π interaction between toluene and the carbon surface by facilitating the polarization of π electrons. Meanwhile, N functional groups can weaken the van der Waals interaction between the carbon surface and water vapor. This study would provide the theoretical hints to develop the VOCs adsorbents in the presence of water vapor.
The High-volume Haemodiafiltration vs High-flux Haemodialysis Registry Trial (H4RT): a multi-centre, unblinded, randomised, parallel-group, superiority study to compare the effectiveness and cost-effectiveness of high-volume haemodiafiltration and high-flux haemodialysis in people with kidney failure on maintenance dialysis using linkage to routine healthcare databases for outcomes.
Authors: Caskey Fergus J , Procter Sunita , MacNeill Stephanie , Wade Julia , Taylor Jodi , Rooshenas Leila , Liu Yumeng , Annaw Ammar , Alloway Karen , Davenport Andrew , Power Albert , Farrington Ken , Mitra Sandip , Wheeler David C , Law Kristian , Lewis-White Helen , Ben-Shlomo Yoav , Hollingworth Will , Donovan Jenny , Lane J Athene 
Published: March 2022

Abstract
Background
More than a third of the 65,000 people living with kidney failure in the UK attend a dialysis unit 2–5 times a week to have their blood cleaned for 3–5 hours. In haemodialysis (HD) toxins are removed by diffusion, which can be enhanced using a high-flux dialyser. This can be augmented with convection, as occurs in haemodiafiltration (HDF) and improved outcomes have been reported in people who are able to achieve high volumes of convection. This study compares the clinical- and cost-effectiveness of high-volume HDF compared with high-flux HD in the treatment of kidney failure.
Methods
This is a UK-based, multi-centre, non-blinded randomised controlled trial. Adult patients already receiving HD or HDF will be randomised 1:1 to high-volume HDF (aiming for 21 + L of substitution fluid adjusted for body surface area) or high-flux HD. Exclusion criteria include lack of capacity to consent, life expectancy less than 3 months, on HD/HDF for less than 4 weeks, planned living kidney donor transplant or home dialysis scheduled within 3 months, prior intolerance of HDF, and not suitable for high-volume HDF for other clinical reasons. The primary outcome is a composite of non-cancer mortality or hospital admission with a cardiovascular event or infection during follow-up (minimum 32 months, maximum 91 months) determined from routine data. Secondary outcomes include all-cause mortality, cardiovascular and infection related morbidity and mortality, health-related quality of life, cost-effectiveness and environmental impact. Baseline data will be collected by research personnel on-site. Follow up data will be collected by linkage to routine healthcare databases – Hospital Episode Statistics, Civil Registration, Public Health England, and the UK Renal Registry (UKRR) in England, and equivalent databases in Scotland and Wales, as necessary – and centrally administered patient completed questionnaires. In addition, research personnel on-site will monitor for adverse events and collect data on adherence to the protocol (monthly during recruitment and quarterly during follow-up).
Discussion
This study will provide evidence of the effectiveness and cost effectiveness of HD as compared to HDF for adults with kidney failure in-centre HD or HDF. It will inform management for this patient group in the UK and internationally.
Trial registration:
ISRCTN10997319. Registered on 10th October 2017.
Comparative Analysis of Anatomical, Phytochemical and Molecular Genetic Characteristics of Two Species of Hedysaruml.
Authors: Kusmangazinov A.B. , Kurmanbayeva Meruyert Sakenovna , Zharkova I.M. , Sarkytbayeva A. K. , Kayirbekov T.K. , Hohn M. 
Published: March 2022

Abstract
Background
Hedysarum L. is one of the large families of the Fabaceae, consisting of 200 species. Species in the genus Hedysarum are valuable forage and medicinal resources. In this paper we studied Hedysarum theinum Krasnob. and Hedysarum neglectum Ledeb. growing in the Western Altai of Eastern Kazakhstan. H.theinum is a perennial, herbaceous, valuable medicinal plant, a rare high-altitude species, an Altai-Dzungarian endemic and globally endangered species. H. neglectum is a perennial plant of high medicinal and fodder value, growing mainly in the sub-alpine zone. A complex phytochemical study of Hedysarum using modern methods, expanding the data on herbal medicines is actual. At the current time, taxonomic and phylogenetic questions of the genus Hedysarum are the subject of close attention, as the systematic knowledge of the genus Hedysarum L. Fabaceae: Hedysareae is still incomplete. Therefore, questions are being actively addressed by correlating data obtained by molecular genetic analyses. In the study, route-recognition methods were used in a field search of two species of Hedysarum for comparative morphological study in 2020–2021.
Results
The morphological measurements showed a difference in the external structure of the two species. Structural changes in the anatomical structure of the leaf, stem and root were analyzed as the plants adapted to different conditions in the Western Altai. The changes were expressed in the transition from the typical dorsiventral leaf structure of H.theinum to the isolateral-palisade structure of the mesophyll of H.neglectum. The phytochemical analysis revealed the highest amount of ethyl α-d glucopyranoside at 45.23% in the subterranean part of H. theinum, which was only 0.8% in H. neglectum. The root part of H. theinum contained the highest vitamin E content of 11.36%, while the above-ground part of H. neglectum showed an insignificant amount of tocopherol at 0.37%. Also the above-ground and underground parts of the two species contain squalene, which has an antioxidant effect and strengthens the immune system. Nowadays, an urgent task in pharmacognosy is the use of all kinds of DNA analysis methods for the identification of plant raw materials. In this regard, the possibility of using molecular genetic methods of research in the analysis of representatives of the genus Hedysarum L., for the identification of medicinal plant raw materials was studied.
Conclusion
Phylogenetic analysis using molecular genetic markers revealed that H. neglectum and H. theinum belong to the Hedysarum section. The data obtained can be used for the species identification of H.theinum and H.neglectum, which has so far been difficult due to the lack of some systematic morphological characters. The results obtained may be useful for the taxonomic studies of this section.
Male Origin Microchimerism and Brain Cancer: a Case-cohort Study
Authors: Kamper-Jørgensen Mads , Jakobsen Marianne Antonius , Tjønneland Anne , Skjøth-Rasmussen Jane , Petersen Gitte Lindved , Hallum Sara 
Published: March 2022

Abstract
Background: Despite considerable research effort, causes of brain cancer are largely unknown. Male BC predominance and reduced brain cancer risk with increasing parity among women, however, support a favourable role of pregnancy. We set out to determine whether peripheral male origin microchimerism, namely the presence of circulating male origin cells, likely obtained via natural trafficking across the placenta during pregnancy, associates with reduced risk of brain cancer in women.Methods: Using a case-cohort design, we sampled 505 middle aged women randomly at baseline in the Diet, Cancer and Health cohort (controls), and 73 women with incident brain cancer diagnosed during follow-up in the Danish Cancer Registry (cases). Male origin microchimerism was determined by presence of Y chromosome sequences in female blood samples. Data was analysed using weighted proportional Hazards regression, yielding Hazard Ratios with 95% confidence intervals.Results: Compared with male origin microchimerism negative women, positive women had half the risk of developing brain cancer (Hazard Ratio=0.50 [0.33-0.77]). Sensitivity analyses support that our findings are unlikely due to bias or chance.Conclusion: Here, for the first time we demonstrate half the risk of brain cancer in male origin microchimerism positive compared with negative women. Our findings resemble those of previous studies of male origin microchimerism and other female cancers.
Long Term Longitudinal Follow up of AD-HIES Cohort: Impact of Early Diagnosis and Enrolment to IPINet Centres on Natural History of Job Syndrome
Authors: Carrabba Maria , Dellepiane Rosa Maria , Cortesi Manuela , Baselli Lucia Augusta , Soresina Annarosa , Cirillo Emilia , Giardino Giuliana , Conti Francesca , Dotta Laura , Finocchi Andrea , Cancrini Caterina , Milito Cinzia , Pacillo Lucia , Cinicola Bianca Laura , Cossu Fausto , Consolini Rita , Montin Davide , Quinti Isabella , Pession Andrea , Fabio Giovanna , Pignata Claudio , Pietrogrande Maria Cristina , Badolato Raffaele 
Published: March 2022

Abstract
The Job Syndrome or Autosomal Dominant Hyper Immunoglobulin E Syndrome (AD-HIES, LOF-STAT3 gene) is a very rare inborn error of immunity disorder with multi-organ involvement and long-life post-infective damages. Longitudinal registries are of main importance to improve knowledge on natural history and management of these rare disorders. This study aims to describe the natural history of 30 Italian patients recorded in the IPINet registry with AD-HIES, with a cumulative observational-time of 721.1 patient-years. Age at disease onset was < 12 months in the 66.7% of patients, but the mean time of diagnostic delay was 13.7 years. At diagnosis skin involvement was present in 93.3% of patients (eczema 80.8%, abscess 66.7%). At the follow up eczema was still present in 63.3% and abscess in 56.7%. Respiratory complications such as bronchiectasis and pneumatoceles were present at diagnosis in the 46.7% and 43.3% respectively. Antimicrobial prophylaxis resulted in decrease of pneumonia from 76.7–46.7%. Antifungal prophylaxis decreased mucocutaneous candidiasis occurrence from 70–56.7%. In the course of SARS-CoV-2 pandemic, seven patients developed COVID-19. Survival analyses showed that 27 out of 30 patients are still alive, while three patients died at age of 28, 39 and 46 as consequence of lungs bleeding, lymphoma and sepsis, respectively. Our study shows that many severe complications can affect AD-HIES patients. Analysis of a cumulative follow-up of 278.7 patient-years has shown that early diagnosis, adequate management at expertise centres for primary immunodeficiency, prophylactic antibiotic and antifungal therapy improve outcome and can positively influence patients’ life expectancy.
A retrospective analysis of the efficacy of endoscopic variceal ligation versus endoscopic tissue adhesive injection in the treatment of esophagogastric variceal bleeding
Authors: Liu Wei , Xu Linxia , Xu Feng , Wang Jianchao , Deng Min , Zheng Hailun , Ma Zhenzeng , Xue Yongju , Wang Qizhi , Ke Xiquan 
Published: March 2022

Abstract
Objective
To investigate the effectiveness and safety of endoscopic variceal ligation (EVL) and endoscopic tissue adhesive injection (TAI) in the treatment of esophagogastric variceal bleeding.
Methods
245 patients with esophagogastric variceal bleeding attending the First Affiliated Hospital of Bengbu Medical College from December 2017 to June 2021 were retrospectively collected and divided into 103 patients in the esophageal EVL(E-EVL) + gastric EVL(G-EVL) group and 142 patients in the E-EVL + gastric TAI(G-TAI) group according to the procedure, comparing and assessing the clinical characteristics, laboratory results, operation time, rebleeding rate, efficacy, and complications in the two groups.
Results
The diameter of the varicose veins and the operative time were significantly less in the E-EVL + G-EVL group than in the E-EVL + G-TAI group (p < 0.05), there was no statistical difference in the length of stay in hospital between the two groups (p > 0.05). The total rebleeding rate in the E-EVL + G-EVL group was 9.7%; the total rebleeding rate in the E-EVL + G-TAI group was 11.9%, and there was no statistical difference between the two groups (P > 0.05). The overall effective rate of the E-EVL + G-EVL group was 90.21%; the overall effective rate of the E-EVL + G-TAI group was 92.81%, and there was no statistical difference between the two groups (P > 0.05). The postoperative ulcer in the E-EVL + G-EVL group were smaller and more superficial than those in the E-EVL + G-TAI group, and the wound surface was smoother.
Conclusion
Both endoscopic variceal ligation and endoscopic tissue adhesive injection have good therapeutic effects on esophagogastric variceal bleeding, and gastric endoscopic variceal ligation is worthy of further clinical promotion because of its effectiveness in preventing re-bleeding, no reduction in efficacy and no increase in complications, shortened operative time, smaller and superficial ulcer and smoother wounds.
Nonmonotone invasion landscape by engineered control of metastasis activator levels
Authors: Wan Yiming , Cohen Joseph , Szenk Mariola , Farquhar Kevin , Nest Nicholas Van , Smashnov Alex , Chern Yi-Jye , Bien Harold , Chan Chia-Hsin , Balázsi Gábor 
Published: March 2022

Abstract
A major pharmacological goal is targeting oncogenic transcription factors, by the assumption that lowering disease-promoting protein levels is generally beneficial. For example, inhibiting metastasis activator BACH1 is proposed to decrease metastasis in human cancers. Testing such assumptions requires measuring disease phenotypes while precisely adjusting disease-promoting protein levels, which is not routinely available. Here we develop a strategy to insert protein-level tuning synthetic gene circuits into the same genomic locus of human cell lines. Unexpectedly, the invasiveness of engineered MDA-MB-231 metastatic breast cell increases and then decreases while tuning BACH1 levels up. BACH1 expression-shifts in invading cells, and expression of BACH1’s direct target RKIP confirm BACH1’s nonmonotone phenotypic and regulatory effects. Thus, inhibiting BACH1 can be harmful and promoting BACH1, beneficial. Additionally, BACH1’s expression variability aids invasion at high BACH1 expression. Overall, precisely engineered protein level control is necessary and sufficient to unravel disease effects of genes, thereby improving the efficiency of drug development.
Evaluation of the Factors Affect Vision Related Quality of Life and Level of Depression in the Patients With Age-Related Macular Degeneration
Authors: Dogan Levent , Tanriverdi Derya , Gungor Kıvanc 
Published: March 2022

Abstract
Purpose: To determine the effect of age-related macular degeneration (AMD) on Vision Related Quality of Life (VRQOL) and depression level.Method: 54 patients followed up or newly diagnosed with AMD in Ophthalmology Clinic at Gaziantep University had been included in this cross-sectional study. The Turkish version of the National Eye Institute Visual Functioning Questionnaire-25 (NEI VFQ-25) and Geriatric Depression Scale-15 (GDS-15) were assessed to the patients. The results of these two questionnaires were evaluated according to the demographic findings of the patients, the severity and treatment procedures of the AMD. Results: The scores obtained from subscales varied from 43,48 for ‘Near activities’ to 81,48 for ‘Color vision’ subscales in NEI VFQ-25 test. According to the results of GDS-15 questionnaire, we detected that 63% of all the patients compatible with depression when the cut-off value was accepted as ‘5’. Intravitreal anti-VEGF injection as a treatment procedure had no correlation with depression (p>0.05).Conclusion: The lowest and highest scores had been obtained in ‘Near activities’ and ‘Color vision’ respectively. The patients with AMD had higher depression level. The female AMD patients had higher rates of depression and lower visual acuity levels.