bluuebunny/crossref_metadata_2025_split huggingface dataset:
The genetic structure and connectivity in two sympatric rodent species with different life histories are similarly affected by land use disturbances
Authors: Biello Roberto , Brunelli Andrea , Sozio Giulia , Havenstein Katja , Mortelliti Alessio , Ketmaier Valerio , Vilaça Sibelle Torres , Bertorelle Giorgio 
Published: November 2022

AbstractThe negative impact of habitat fragmentation due to human activities may be different in different species that co-exist in the same area, with consequences on the development of environmental protection plans. Here we aim at understanding the effects produced by different natural and anthropic landscape features on gene flow patterns in two sympatric species with different specializations, one generalist and one specialist, sampled in the same locations. We collected and genotyped 194 wood mice (generalist species) and 199 bank voles (specialist species) from 15 woodlands in a fragmented landscape characterized by different potential barriers to dispersal. Genetic variation and structure were analyzed in the two species, respectively. Effective migration surfaces, isolation-by-resistance (IBR) analysis, and regression with randomization were used to investigate isolation-by-distance (IBD) and the relative importance of land cover elements on gene flow. We observed similar patterns of heterozygosity and IBD for both species, but the bank vole showed higher genetic differences among geographic areas. The IBR analysis suggests that (i) connectivity is reduced in both species by urban areas but more strongly in the specialist bank vole; (ii) cultivated areas act as dispersal corridors in both species; (iii) woodlands appear to be an important factor in increasing connectivity in the bank vole, and less so in the wood mouse. The difference in dispersal abilities between a generalist and specialist species was reflected in the difference in genetic structure, despite extensive habitat changes due to human activities. The negative effects of fragmentation due to the process of urbanization were, at least partially, mitigated by another human product, i.e., cultivated terrains subdivided by hedgerows, and this was true for both species.
On strongly walk regular graphs, triple sum sets and their codes
Authors: Kiermaier Michael , Kurz Sascha , Solé Patrick , Stoll Michael , Wassermann Alfred 
Published: November 2022

AbstractStrongly walk regular graphs (SWRGs or s-SWRGs) form a natural generalization of strongly regular graphs (SRGs) where paths of length 2 are replaced by paths of length s. They can be constructed as coset graphs of the duals of projective three-weight codes whose weights satisfy a certain equation. We provide classifications of the feasible parameters of these codes in the binary and ternary case for medium size code lengths. For the binary case, the divisibility of the weights of these codes is investigated and several general results are shown. It is known that an s-SWRG has at most 4 distinct eigenvalues $$k> \theta _1> \theta _2 > \theta _3$$

k
>

θ
1

>

θ
2

>

θ
3

, and that the triple $$(\theta _1, \theta _2, \theta _3)$$

(

θ
1

,

θ
2

,

θ
3

)

satisfies a certain homogeneous polynomial equation of degree $$s - 2$$

s
-
2

(Van Dam, Omidi, 2013). This equation defines a plane algebraic curve; we use methods from algorithmic arithmetic geometry to show that for $$s = 5$$

s
=
5

and $$s = 7$$

s
=
7

, there are only the obvious solutions, and we conjecture this to remain true for all (odd) $$s \ge 9$$

s
≥
9

.
Friendships in Children with Williams Syndrome: Parent and Child Perspectives
Authors: Gillooly Amanda E. , Riby Deborah M. , Durkin Kevin , Rhodes Sinéad M. 
Published: November 2022

AbstractAlthough children with Williams syndrome (WS) are strongly socially motivated, many have friendship difficulties. The parents of 21 children with WS and 20 of the children themselves participated in a semi-structured interview about the children’s friendships. Parents reported that their child had difficulties sustaining friendships and low levels of interaction with peers. Barriers to friendships included difficulties with play and self-regulating behaviour. However, there was within-group variability, with a small number of children reported to have strong friendships. While parents reported friendship challenges, all of the children named at least one friend, and most said that they had never felt excluded by their peers. Future research is needed to determine optimal ways to support children with WS in their friendships.
Nature-inspired discontinuous calcium coatings on polyglycolic acid for orthopaedic applications
Authors: Lui F. H. Y. , Wang Y. , Mobbs R. J. , Sorrell C. C. 
Published: November 2022

AbstractNon-union in spinal fusion surgeries (SF) is a key cause of failure. Demineralized bone matrix is used in SFs to facilitate bone growth throughout the segment, and polyglycolic acid (PGA) meshes are used for their containment. A discontinuous calcium mineral coating could transform the function of PGA meshes from passive to active, where dissolved calcium ions could act as a chemoattractant for bone cells or it could form a barrier to prevent hydrolytic degradation of the mesh to better align its degradation profile with the fusion process. Challenges to depositing a mineral coating on PGA include its low glass transition temperature (~ 35 °C) and hydrolytic degradation.
Inspired by calcite rafts in limestone cave pools, calcite grains were deposited on PGA meshes at the air–solution interface of supersaturated Ca(HCO3)2 (33 °C 6 h). X-ray diffraction (XRD) and 3D confocal microscopy were performed to assess phase composition and coating morphology. Durability was qualitatively assessed by mechanical tests. In vitro incubation was performed to elucidate the dynamic interactions between coating dissolution and PGA degradation; pH and calcium concentration of the solution were measured.XRD confirmed that coated PGA meshes were comprised of PGA and crystalline calcite. 3D confocal microscopy showed that the coatings were discontinuous and comprised of rhombohedral microcrystals. Retention of the particles following ultrasonic treatment and flexure/tensile testing indicates durability. Notably, the grains were compliant as the mesh was contorted. The interaction effect between the incubation time and pH for the uncoated and coated samples was statistically significant (p < 0.05).
Graphical Abstract
Exploring the Relationship Between Compassion and Attachment in Individuals with Mental Health Difficulties: A Systematic Review
Authors: Amari Nicola , Martin Tasim , Mahoney Adam , Peacock Shona , Stewart Janet , Alford Erin Alexandra 
Published: November 2022

AbstractThe objective of the review was to explore the relevance of the relationship of compassion and attachment to mental health. APAPsycInfo, APAPsycArticles, CINAHL, MEDLINE, Social Science Database, Sociology Database, PTSDpubs, Pubmed, and Web of Science were searched from their inception until November 9, 2021. Peer-reviewed empirical studies exploring the compassion–attachment relationship in individuals with mental health difficulties through outcome measures were included. Studies were excluded if non-empirical, with non-clinical/subclinical samples, in a language other than English and if they did not consider the compassion–attachment relationship. Risk of bias was assessed through The Newcastle–Ottawa Scale and the Downs and Black Checklist. Seven eligible studies comprising 4839 participants were identified, with low to moderate risk of overall bias. Findings indicated a more straightforward relationship between self-compassion and secure attachment and confirmed the relevance of compassion and attachment to psychological functioning. Limitations concerned study design, the use of self-report measures, and low generalisability. While suggesting mechanisms underpinning compassion and attachment, the review corroborates the role of secure attachment and self-compassion as therapeutic targets against mental health difficulties. This study is registered on PROSPERO number CRD42021296279.
A case study of process performances during a small-group activity: comparison between a round-shaped and a crescent-shaped seating arrangements in studio-style learning spaces
Authors: Hayashi Kazumasa , Mochizuki Toshio , Yamauchi Yuhei 
Published: November 2022

AbstractThis research explored the best shapes and layouts of seating arrangements for fostering process performances of students in studio-style learning spaces, which have emerged in the development of collaborative learning environments in higher education. We conducted a design case study to explore both team and individual process performances during a small-group activity in a round-shaped and a crescent-shaped seating arrangement. Evaluators observed and measured the individual process performance of each group member together with the team process performances of each group. All factor scores of the individual process performance were higher in the crescent-shaped seating arrangement than in the round-shaped seating arrangement, with substantive effect sizes. In the group process performance, the factor scores of ‘planning and process’ and ‘independence and leadership’ in the crescent-shaped seating arrangement were substantially higher than those of the round-shaped arrangement, indicating that the crescent-shaped seating arrangement fostered students’ ability to collaborate responsibly in their project work. Video analysis revealed that groups in the crescent-shaped layout tended to have more eye-contact and to spend less time planning, which indicates that such sociopetal effects have the potential to promote efficiency in the discussion between people seated in a crescent-shaped arrangement. We discuss the necessity to take students’ seating arrangements into consideration regarding the sociopetal, as well as a proximal focal point and less-disparate distance between the leader and other participants to allow them to engage in their own work better.
The role of Nod-like receptor protein 3 inflammasome activated by ion channels in multiple diseases
Authors: Xu Xiaolin , Wu Xianli , Yue Gengyu , An Qimin , Lou Jun , Yang Xiaoxu , Jin Zhe , Ding Jianhong , Hu Yanxia , Du Qian , Xu Jingyu , Xie Rui 
Published: November 2022

AbstractThe inflammasome is a multimeric protein complex located in the cytoplasm that is activated by many factors and subsequently promotes the release of proinflammatory factors such as interleukin (IL)-1β and IL-18, resulting in a series of inflammatory responses that ultimately lead to the occurrence of various diseases. The Nod-like receptor protein 3 (NLRP3) inflammasome is the most characteristic type and the most widely studied among many inflammasomes. Activation of the NLRP3 inflammasome is closely related to the occurrence of many diseases, such as Alzheimer's disease. At present, a large number of studies have focused on the mechanisms underlying the activation of the NLRP3 inflammasome. Plenty of articles have reported the activation of the NLRP3 inflammasome by various ions, such as K+ and Na+ reflux and Ca2+ influx. However, few articles have reviewed the effects of various ion channels on the activation of the NLRP3 inflammasome and the relationship between the diseases caused by these proteins. This article mainly summarizes the relationship between intracellular and extracellular ion activities and ion channels and the activation of the NLRP3 inflammasome. We also provide a general summary of the diseases of each system caused by NLRP3 activation. We hope that more research will provide options for the treatment of diseases driven by the NLRP3 inflammasome.
Gut microbiota-derived metabolites and their importance in neurological disorders
Authors: Swer Nicole Mary , Venkidesh B S , Murali Thokur Sreepathy , Mumbrekar Kamalesh Dattaram 
Published: November 2022

AbstractMicrobial-derived metabolites are the intermediate or end products of bacterial digestion. They are one of the most important molecules for the gut to connect with the brain. Depending on the levels of specific metabolites produced in the host, it can exert beneficial or detrimental effects on the brain and have been linked to several neurodegenerative and neuropsychiatric disorders. However, the underlying mechanisms remain largely unexplored. Insight into these mechanisms could reveal new pathways or targets, resulting in novel treatment approaches targeting neurodegenerative diseases. We have reviewed selected metabolites, including short-chain fatty acids, aromatic amino acids, trimethylamine-N-oxide, urolithin A, anthocyanins, equols, imidazole, and propionate to highlight their mechanism of action, underlying role in maintaining intestinal homeostasis and regulating neuro-immunoendocrine function. Further discussed on how altered metabolite levels can influence the gut–brain axis could lead to new prevention strategies or novel treatment approaches to neural disorders.
House Prices and Flood Risk Exposure: An Integration of Hedonic Property Model and Spatial Econometric Analysis
Authors: Bui Nam , Wen Le , Sharp Basil 
Published: November 2022

AbstractThe impact of climate change is devastating in developing countries where flood protection and insurance schemes are limited. Certain parts of Ho Chi Minh City, Vietnam are under the constant threat of inundation due to sea-level rise. We integrate the hedonic property model in a difference-in-differences framework and spatial econometric analysis into a single analytical framework to estimate the economic effect of pluvial flooding. We find prices for affected houses were discounted by 9% after a large flood event on 30 September 2017. This research contributes to the existing literature as follows. First, we study the economic impact of pluvial floods, which has received less attention in existing studies where large and irregular floods are their focus. Second, the inclusion of legal status as a control variable accounts for the unique character of the Vietnamese housing market. Third, we also identify the recovery of house prices after the flood event.
The practices of a raqi (Islamic exorcist) in Stockholm
Authors: Marlow Michael 
Published: November 2022

AbstractThis article investigates in depth the practices of a Stockholm-based raqi. In the first section, the principles and methods of his version of ruqya (Islamic exorcism) are described: which Qur’anic passages he perceives as being most suitable to read in the cases of different afflictions, how he complement his reading with the use of his right palm to detect the possession, and his use of the “satanic meridians,” i.e., pressure points to use to facilitate the eviction of stubborn djinns. Later, the cases of five patients are discussed in order to shed light upon those who seek out his services. One particularly interesting example concerns a patient who regularly takes ruqya against sorcery. Despite the fact that she does not believe in sorcery herself, she considers ruqya more beneficial for her well-being than Western treatments. Next, the raqi’s perspective on psychotherapy and on mental illness in general are then presented. Finally, the problems of non-contextualized interviews versus ethnographic observations carried out as part of fieldwork for the purposes of gathering information are illustrated.
Legal Aspects of Migraine in the Workplace
Authors: Riggins Nina , Paris Lorenzo 
Published: November 2022

Abstract
Purpose of Review
This study explores legal aspects of migraine in the workplace. While the high prevalence of migraine is well-documented, its effects on the livelihoods of those living with the disease are less understood. Because migraine symptoms are often invisible, discussions concerning migraine in the workplace can be challenging. What are the rights of persons with migraine in the workplace? Time off may provide a brief respite, but it is not a long-term solution. Claiming disability for migraine has challenges, including barriers to doing so and required paperwork. How can persons with migraine remain employed and productive? How can persons with migraine receive accommodation from their employer or take time off to treat their condition?

Recent Findings
Many employers offer comprehensive benefit packages that allow for sick days, time off, mental health days, and accommodations that may give persons with migraine temporary reprieve. However, it may not be sufficient, particularly for those with chronic migraine. Further, not all employers offer comprehensive benefits. Employees with migraine may need to seek protection under the law. Our research closely examines the primary legal avenues that persons with migraine may pursue while living and working with migraine. In exploring the legal aspects of migraine, we couple our exploration with relevant case law.

Summary
Through this lens, we conclude that migraine is becoming less stigmatized and more legitimized in the eyes of the court. It is the belief of the authors that at least some of the change in the attitude towards migraine is the result of strong patient advocacy and significant advances in research over the past several years.
Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells
Authors: Levert Stéphanie , Pilliod Julie , Aumont Étienne , Armanville Sandrine , Tremblay Cyntia , Calon Frédéric , Leclerc Nicole 
Published: November 2022

Abstract
In Alzheimer disease (AD), Tau, an axonal microtubule-associated protein, becomes hyperphosphorylated, detaches from microtubules, accumulates, and self-aggregates in the somatodendritic (SD) compartment. The accumulation of hyperphosphorylated and aggregated Tau is also seen in other neurodegenerative diseases such as frontotemporal lobar degeneration (FTLD-Tau). Previous studies reported a link between filamin A (FLNA), an actin-binding protein found in the SD compartment, and Tau pathology. In the present study, we further explored this link. We confirmed the interaction of Tau with FLNA in neuroblastoma 2a (N2a) cells. This interaction was mediated by a domain located between the 157 and 383 amino acids (a.a.) of Tau. Our results also revealed that the overexpression of FLNA resulted in an intracellular accumulation of wild-type Tau and Tau mutants (P301L, V337M, and R406W) in N2a cells. Tau phosphorylation and cleavage by caspase-3 but not its aggregation were increased upon FLNA overexpression in N2a cells. In the parietal cortex of AD brain, insoluble FLNA was increased compared to control brain, but it did not correlate with Tau pathology. Interestingly, Tau binding to microtubules and F-actin was preserved upon FLNA overexpression in N2a cells. Lastly, our results revealed that FLNA also induced the accumulation of annexin A2, a Tau interacting partner involved in its axonal localization. Collectively, our data indicated that in Tauopathies, FLNA could contribute to Tau pathology by acting on Tau and annexin A2.
Optimierte Designer-Enzyme für die pharmazeutische Industrie
Authors: Kunzendorf Andreas , Bornscheuer Uwe T. 
Published: November 2022

AbstractEnzymes, the driving biocatalysts in living organisms, are typically not suited for large-scale industrial use. In the last decade, enzyme engineering has evolved into the key technology to design tailor-made enzymes for chemical and pharmaceutical applications. We highlight current trends in enzyme engineering and biocatalysis based on outstanding examples from the pharmaceutical industry.
Einzelzellmikroskopie im Hochdurchsatz auf Mikrostrukturen
Authors: Müller Judith A. , Schwake Gerlinde , Rädler Joachim O. 
Published: November 2022

AbstractCellular response to perturbations, if examined at the single cell level, exhibits cell-to-cell differences, distinct dynamic behavior and correlations meaningful for the study of regulatory networks and information processing. Live-cell imaging on single cell arrays (LISCA) facilitates automated acquisition of individual time courses with sharp temporal resolution. Here we discuss expression dynamics after transient GFP transfection and event-time correlations in nanoparticle induced apotosis.
The meiofauna of the Eratosthenes Seamount (eastern Mediterranean Sea)—first insights into taxa composition, distribution, and diversity
Authors: George Kai Horst 
Published: November 2022

AbstractDuring the research cruise MSM 14/1 of RV M.S. MERIAN to the eastern Mediterranean Eratosthenes Seamount in 2009/2010, samples were taken with a multiple corer to get first insights into the composition, abundance, and diversity of the meiofauna. Along two transects, a north–south and a west–east ones, 14 sites were sampled on the seamount. Additionally, a distant deep-sea site provided meiobenthic material for comparison with that of the seamount. Altogether, 15 meiobenthic major taxa were found. Nematoda and Copepoda Harpacticoida strongly dominated all sites, followed by Annelida and Tardigrada at most sites. Although direct comparison pointed towards a northern seamount community, this could not be confirmed by a detailed community analysis regarding taxa composition, abundance expressed by density (ind./10 cm2), and taxa diversity. It revealed neither a homogeneous seamount community nor any faunistic relation with bathymetric or geographic gradients, with exception of the taxa diversity that apparently followed a latitudinal gradient. Generally, Eratosthenes Seamount presents a quite heterogeneous meiobenthic assemblage that may be linked to small-scale biotic and abiotic variables. Moreover, also the distant reference site did not differ significantly from the seamount sites. A brief comparison with other Atlantic and Mediterranean seamounts and islands indicates that Eratosthenes Seamount is not characterized by an impoverished meiobenthic fauna.
Children’s Sense of Belonging in the Context of Post-separation Parental Stalking: Finnish Children’s Experiences of their Family Relations
Authors: Nikupeteri Anna , Laitinen Merja , Kallinen Kati 
Published: November 2022

AbstractDrawing from previous research on domestic violence and stalking, this study addresses children’s experiences of their family relations in post-separation parental stalking contexts from the perspective of stalking as a form of violence against women and children. Despite the fact that violence perpetrated by a parent fundamentally changes family dynamics and children’s perceptions of family security, research on children’s family relations in the course of domestic violence or stalking has rarely addressed children’s sense of belonging. The aim of this paper is to augment our understanding of children’s experiences of family relations in connection with parental stalking. The research question is: How do children experience their belonging in family relations in the context of post-separation parental stalking? A total of 31 children and young people aged 2–21 participated in the study. The data were collected through interviews and therapeutic action group sessions with the children. The qualitative data analysis was content-oriented. Four dimensions of children’s sense of belonging were identified: (1) Varying belonging, (2) distancing belonging, (3) non-belonging and (4) holding belonging. The first three dimensions are constructed in relation to the child’s stalking father, while the fourth one includes the mother, siblings and other relationships that provide safety and comfort. The dimensions are parallel and not mutually exclusive. The study indicates that a finer-grained understanding of children’s sense of belonging in family relations is needed when social and health care and law enforcement professionals evaluate the child’s safety and best interest.