bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring enablers and obstacles to policy‐oriented learning in Swedish marine national park planning
Authors: Morf Andrea , Sandström Annica , Söderström Sara 
Published: May 2022

AbstractThis article deepens our understanding of the preconditions for policy‐oriented learning in conflictive marine conservation, provides an analytical framework for further studies and formulates recommendations for practitioners on what to consider when establishing protected areas. Our seas are under increasing pressure but lag behind in protection. Climate change, intensifying use and biodiversity loss challenge current practises and imply trade‐offs between conservation and use. While nature conservation ranks high internationally, national protection attempts often result in controversies, with actors aligning in opposing advocacy coalitions—for and against the proposals. Policy‐oriented learning is one way to overcome controversies. It involves processes whereby actors gain new knowledge and experiences, leading to changed beliefs about the problems and possible solutions. We aimed to explore and explain policy‐oriented learning through a comparative longitudinal case study of two Swedish national park planning processes with different outcomes: Koster Sea national park, established 2009, and Sankt Anna archipelago remaining without park. Which characteristics related to context, actors and processes influence policy‐oriented learning in conflictive marine conservation processes? The results suggest that a set of complementary factors explain the different outcomes. First, learning is facilitated by contexts where actors from both coalitions depend on the resource and its protection and have experience of collaboration, and where conservation planning is well integrated with other governance processes. Second, engaged key actors with moderate views facilitating interactions and able to identify common interests and deescalate conflicts are important — supported, third, by various forums allowing exchange of knowledge and learning across coalitions.
Occurrence of Microplastics in Borehole Drinking Water and Sediments in Lagos, Nigeria
Authors: Oni Babalola Aisosa , Sanni Samuel Eshorame 
Published: May 2022

Abstract
We investigated the occurrence of microplastics in samples of borehole drinking water and sediments obtained from borehole sites in Lagos Island, Nigeria. The samples were digested with hydrogen peroxide, pretreated, and filtered through a polytetrafluoroethylene membrane. The filtered microplastics were examined/analyzed under an attenuated total reflection Fourier-transformed infrared device, to quantify the microplastics. The results showed the presence of microplastics in drinking water and sediments from the sites, with plastic concentrations ranging from 206 to 1691 items m−3 and 9–47 items kg−1 for drinking water and sediments, respectively; polypropylene was the most common and was approximately 61.9% for borehole drinking water. In terms of shape distribution, plastic fragments were the highest, at 73.02%. The detected microplastics had a size range of 0.02–0.5 mm. In addition, sites with a lower percentage of microplastics had lower population densities and lower industrial activity, whereas areas of high industrial activity had high amounts of microplastics. Environ Toxicol Chem 2022;41:1721–1731. © 2022 SETAC
Favorable impact of long‐term SGLT2 inhibitor for NAFLD complicated by diabetes mellitus: A 5‐year follow‐up study
Authors: Akuta Norio , Kawamura Yusuke , Fujiyama Shunichiro , Saito Satoshi , Muraishi Nozomu , Sezaki Hitomi , Hosaka Tetsuya , Kobayashi Masahiro , Kobayashi Mariko , Arase Yasuji , Ikeda Kenji , Suzuki Fumitaka , Suzuki Yoshiyuki , Kumada Hiromitsu 
Published: May 2022

Abstract
The aim of this study was to determine the impact at 5 years of sodium‐glucose cotransporter 2 inhibitor (SGLT2i) in nonalcoholic fatty liver disease (NAFLD) with type 2 diabetes mellitus (T2DM) on liver histopathology and clinical features. In this retrospective study, the histological impacts at 5 years after the start of SGLT2i in NAFLD with T2DM were investigated. Six patients with NAFLD and T2DM were treated for the long term with canagliflozin of SGLT2i, and liver biopsies were obtained at the points of the pretreatment, 24 weeks, 3 years, and 5 years after the start of treatment. The primary outcome was liver histopathological changes at 5 years (defined as decrease in NAFLD activity score of one point or more without worsening in fibrosis stage, compared with the pretreatment). The additional treatment of glucagon‐like peptide 1 receptor agonist (GLP‐1RA) was performed in 2 patients after the point of 3 years, and evaluated as histological worsening. As the primary outcome, histological improvement, no change, and worsening were 50%, 17%, and 33% at 5 years, respectively. Overall, the scores of steatosis, lobular inflammation, ballooning, and fibrosis stage decreased at 5 years in 67%, 33%, 0%, and 33%, respectively. As the secondary outcomes, homeostasis model assessment of insulin resistance and serum ferritin decreased significantly at 5 years. None developed 3‐point major adverse cardiovascular events. Two patients with the addition of GLP‐1RA on SGLT2i did not show the worsening of steatosis, ballooning, and fibrosis stage at 5 years compared with 3 years. Conclusion: A 5‐year follow‐up study with SGLT2i indicated the favorable histological impact on NAFLD with T2DM.
Dynamism and realignment in the HR architecture: Online labor platform ecosystems and the key role of contractors
Authors: Keegan Anne , Meijerink Jeroen 
Published: May 2022

AbstractGiven the widespread contribution of independent contractors to organizational innovation and competitive advantage, it is timely to reassess assumptions about the HRM practices appropriate to their management and the rationale for organizations to work with them. In the original and highly influential HR architecture model of Lepak and Snell (1999), contractor status is viewed as an outcome of the low value and/or low uniqueness of human capital resulting in the proposition to externalize and manage them using either none or minimal compliance‐based HRM practices. Developments in digital technologies and algorithmic management epitomized by online labor platforms prompt us to reconsider these assumptions and to challenge the proposed links between value/uniqueness of human capital, employment mode and HRM practices that are assumed by the HR architecture model. Using insights from online labor platforms, we argue that the significant benefits to firms of working with contractors, coupled with the possibilities offered by algorithmic management to efficiently monitor and regulate their behavior, provide a compelling reason for organizations to choose external employment modes even when workers are key to value creation. We challenge the alignment and stability of the relationships proposed by the HR architecture model, and offer propositions to extend the model by reconsidering the rationale for, and nature of, HRM practices associated with contractors. This reassessment is both timely and relevant given the growing prominence of business models where externalizing workers is central alongside the development of new forms of algorithmic human resource management to control them.
Exergetic and techno‐economic analysis of Moroccan horehound leaves (Marrubium vulgare L.) in forced convection solar and microwave drying
Authors: Bahammou Younes , Lamsyehe Hamza , Tagnamas Zakaria , Kouhila Mounir , Lamharrar Abdelkader , Idlimam Ali , Naji Abdenouri 
Published: May 2022

AbstractThis paper aims to analyze solar and microwave drying of Horehound leaves (Marrubium vulgare) from an exergetic point of view. Solar drying tests in forced convection were performed at airflow rates (150 and 300 m3/h) and air‐drying temperatures (60°C, 70°C, and 80°C), where the microwave tests were performed in microwave powers ranging from 50 to 450 kW. Four performance parameters were investigated: exergy of evaporation, exergy loss, and exergy efficiency, sustainability index, and the improvement potential rate of the drying chamber and drying process. The results show that the exergy efficiency increases with the increase of aerothermal conditions. Exegetic performances essentially depend on the drying air temperatures and the airflow rates. The exergy efficiency of the drying process is higher than that of the drying chamber. The drying characteristics of Horehound leaves treated under microwave irradiation is a crucial process to predict its moisture content design so as to optimize the drying process. The exergetic analysis presented in this manuscript shows an improvement in the sustainability index of the drying processes and the reducing losses due to the irreversibility of large‐scale production of dry plants by using solar dryer systems. The techno‐economic analysis performed on the solar dryer including the calculation of the cost of production of 1 kg of dried product shows the economic profitability of drying this kind of product using the convective solar dryer.
Numerical analysis of hydromagnetic mixed convective flow in an internally heated vertical porous layer using thermal nonequilibrium model
Authors: Rani Hari P. , Leela V. , B Shilpa , Nagabhushana Pulla 
Published: May 2022

AbstractThe inertial and viscous effects on mixed hydromagnetic convection in a vertical porous channel using a local thermal nonequilibrium model with uniformly distributed internal sources are analyzed. The flow in the porous medium is described by the Brinkman–Forchheimer extension of Darcy's momentum equation. The vertical rigid boundaries are maintained at constant but different temperatures and a uniform magnetic field is applied across the porous layer. The governing equations are solved numerically by the finite element method and analytically by the perturbation method. The influence of governing parameters on the flow variables and heat transfer is discussed. An extensive study designates that an increase in the Darcy number enhances the velocity distribution due to increased permeability of the medium while the opposite trend is observed with increasing Hartmann number due to the increased retarding nature of Lorentz force. The presence of an external heat source has a notable impact on the temperature gradient of the fluid, which results in an increase in temperature distribution and thermal state of the fluid. A quantitative increase in heat transfer coefficient results in an increase of fluid temperature toward the electrically nonconducting wall, and as the fluid moves toward the electrically conducting wall the fluid temperature decreases. The results indicate that the Nusselt number declines with an increase in the solid internal heat generation parameter.
Convective heat transfer in magnetohydrodynamic TiO2–CuO/ethylene glycol hybrid nanofluid flow toward stagnation point on a radially stretching disk with thermal radiation
Authors: Chaudhary Santosh , Chouhan Kiran Kunwar 
Published: May 2022

AbstractA prime concern of this analysis is to investigate a steady, two‐dimensional, axisymmetric magnetohydrodynamic (MHD) stagnation point flow of TiO2–CuO/ethylene glycol (TiO2–CuO/EG) hybrid nanofluid through a radially stretched disk. Effects of thermal radiation, viscous dissipation, and Joule heating along convective boundary conditions have been taken into consideration. Suitable similarity conversions have been employed to simplify the set of flow controlling partial differential equations of the arising model. Subsequently, the finite element method has been utilized for computational results of the obtained set of ordinary differential equations with associated boundary conditions. The influence of various pertinent parameters, stretching parameter, solid volume fraction, magnetic parameter, Biot number, radiation parameter, and Brinkman number on dimensionless velocity and temperature have been displayed graphically. Subsequently, the responses of hybrid nanofluid (TiO2–CuO/EG) and regular nanofluid (CuO/EG) for these parameters have been compared pairwise, and it has been observed that nanoparticles in ethylene glycol are both controlling the temperature and improving the fluid velocity. Moreover, variations in local skin friction and local Nusselt number for certain values of embedded parameters have been illustrated in tabulated form. It is comprehended that augmented solid volume fraction, magnetic parameter, local Biot number, radiation parameter, and Brinkman number have improved the temperature profile. The velocity profile has been enhanced for the stretching parameter, while the reverse trend has occurred in the case of solid volume fraction and magnetic parameter. The outcomes of this study may be applicable in solar thermal systems.
Chemical reaction with aligned magnetic field effects on unsteady MHD Kuvshinski fluid flow past an inclined porous plate in the presence of radiation and Soret effects
Authors: Mohana Ramana R. , Venkateswara Raju K. , Raghunath K. 
Published: May 2022

AbstractThe present paper studies the effect of a chemical reaction and aligned magnetic field on an unsteady magnetohydrodynamic free convection Kuvshinski fluid flow past an inclined plate through a porous medium in the presence of Soret and radiation. The plate is assumed to be embedded in a uniform porous medium and moves with a constant velocity in the flow direction in the presence of a transverse magnetic field. The systems of nondimensional governing linear partial differential equations are solved analytically by using the perturbation technique. The influences of various nondimensional parameters on the velocity, the temperature, and the concentration are discussed, as also the effects of various parameters on the skin‐friction coefficient and the rate of heat transfer in the form of Nusselt number and rate of mass transfer in the form of Sherwood number at the surface. Velocity distribution is observed to increase with an increase in viscoelastic parameter and Soret parameter, whereas it shows reverse effects in the case of the aligned magnetic field, inclined parameter, magnetic parameter, the temperature diminishes with the increase of radiation parameter and heat absorption parameter.
Open developmental science: An overview and annotated reading list
Authors: Kalandadze Tamara , Hart Sara A. 
Published: May 2022

AbstractThe increasing adoption of open science practices in the last decade has been changing the scientific landscape across fields. However, developmental science has been argued to be relatively slow in adopting open science practices. One of the barriers to applying open science practices might be a lack of knowing ‘how to start’ among developmental researchers. To address this issue, we followed the format of Crüwell et al. (2019) and created summaries and an annotated list of informative and actionable resources discussing ten topics in developmental science: Open science practices; Issues with reproducibility and replication; Open data, materials and code; Open access; Preregistration; Registered reports; Replication; Incentives; Collaborative developmental science. This article offers researchers in developmental science a starting point for understanding how open science intersects with developmental science. After getting familiarized with this article, developmental scientists should understand the core tenets of open and reproducible developmental science, and feel motivated to start applying open science practices in their workflow.
An induced pluripotent stem cell t(7;12)(q36;p13) acute myeloid leukemia model shows high expression of MNX1 and a block in differentiation of the erythroid and megakaryocytic lineages
Authors: Nilsson Tina , Waraky Ahmed , Östlund Anders , Li Susann , Staffas Anna , Asp Julia , Fogelstrand Linda , Abrahamsson Jonas , Palmqvist Lars 
Published: May 2022

AbstractAcute myeloid leukemia (AML) results from aberrant hematopoietic processes and these changes are frequently initiated by chromosomal translocations. One particular subtype, AML with translocation t(7;12)(q36;p13), is found in children diagnosed before 2 years of age. The mechanisms for leukemogenesis induced by t(7;12) is not understood, in part because of the lack of efficient methods to reconstruct the leukemia‐associated genetic aberration with correct genomic architecture and regulatory elements. We therefore created induced pluripotent stem cell (iPSC) lines that carry the translocation t(7;12) using CRISPR/Cas9. These t(7;12) iPSC showed propensity to differentiate into all three germ layers, confirming retained stem cell properties. The potential for differentiation into hematopoietic stem and progenitor cells (HSPC) was shown by expression of CD34, CD43 and CD45. Compared with the parental iPSC line, a significant decrease in cells expressing CD235a and CD41a was seen in the t(7;12) iPSC‐derived HSPC (iHSPC), suggesting a block in differentiation. Moreover, colony formation assay showed an accumulation of cells at the erythroid and myeloid progenitor stages. Gene expression analysis revealed significant down‐regulation of genes associated with megakaryocyte differentiation and up‐regulation of genes associated with myeloid pathways but also genes typically seen in AML cases with t(7;12). Thus, this iPSC t(7;12) leukemia model of the t(7;12) AML subtype constitutes a valuable tool for further studies of the mechanisms for leukemia development and to find new treatment options.
NCA‐based hybrid convolutional neural network model for classification of cervical cancer on gauss‐enhanced pap‐smear images
Authors: Bingol Harun 
Published: May 2022

AbstractCervical cancer is a very serious disease that deeply affects women's lives, often resulting in death. This type of cancer, which is very common in women, is diagnosed at an early stage and is of vital importance for the success of the treatment. Pap‐smear tests are used by physicians as the primary diagnostic tool to diagnose the disease. In this study, a hybrid deep model is proposed to classify pap‐smear images to detect cervical cancer. In addition, the Gaussian method was applied to improve the images in the original dataset. Feature maps were taken from both the original dataset and the Gaussian‐enhanced dataset in the built hybrid architecture, which used Darknet53 and Mobilenetv2 models as the base. After these obtained feature maps were combined, useless features were extracted and the number of features was reduced by using the Neighborhood Component Analysis (NCA) dimension reduction method. Finally, this optimized feature map was classified into different classifiers. As a result of the experimental studies, it was determined that the proposed hybrid model performed better when compared to other studies in the literature and the accuracy rate was 98.90% in the Support Vector Machines (SVM) classifier.
Acceptable surface limits (ASLs) of skin sensitizers derived from the local lymph node assay (LLNA): BrdU‐ELISA EC1.6 values and their relationships to known sensitization potency information
Authors: Fukushima Asako , Hayashi Tae , Takeyoshi Masahiro 
Published: May 2022

AbstractSkin sensitization is an extremely important risk factor for occupational health and safety, and it would be desirable to set health‐based exposure limits (HBELs) for the quantitative risk assessment (QRA) based on the skin sensitizing potencies of chemical. We attempted to set acceptable surface limits (ASLs) as HBELs for skin sensitizers in the workplace based on the local lymph node assay (LLNA): BrdU‐ELISA EC1.6 values. To calculate the ASLs, a safety assessment factor (SAF)interspecies value of 6, based on the EC1.6 values/human repeat insult patch test (HRIPT) NOEL ratios, a SAFinterindividual value of 10, and a SAFfrequency/duration value of 3 were applied, referring to previous literatures on SAFs for skin sensitization QRA, and the composite SAF was calculated as 180. The ASLs (mg/100 cm2) derived thus for 33 chemicals ranged from 0.001 to 10.417. Comparison of the ranges with known human sensitization potency classes and GHS subcategories revealed that use of GHS Category 1A chemicals needs to be controlled to ensure surface residue levels of less than 1 mg/100 cm2. To minimize sensitization risks, a quantitative sensitization risk assessment method for chemicals and appropriate risk management are necessary. This report provides a potentially useful ASL‐based method of managing sensitization risk derived from LLNA: BrdU‐ELISA EC1.6 values, comparison of the ASLs and known human sensitization potency data showed that GHS subcategorization results would be a primary information notifying ASL ranges to be required for minimizing the sensitization risk.
Bioactive potential of Bio‐C Pulpo is evidenced by presence of birefringent calcite and osteocalcin immunoexpression in the rat subcutaneous tissue
Authors: Queiroz Marcela Borsatto , Inada Rafaela Nanami Handa , Lopes Camila Soares , Guerreiro‐Tanomaru Juliane Maria , Sasso‐Cerri Estela , Tanomaru‐Filho Mário , Cerri Paulo Sérgio 
Published: May 2022

AbstractAs the biocompatibility and bioactive potential of repair materials are desired characteristics in dentistry, the tissue response of Bio‐C Pulpo, a bioceramic material launched on the marked by Angelus (Brazil), was compared with Biodentine (Septodont, France) and White MTA (WMTA; Angelus, Brazil). In 32 rats, 148 polyethylene tubes filled with Bio‐C Pulpo, Biodentine or WMTA, and empty (CG, control group) were implanted into subcutaneous tissues for 7, 15, 30, and 60 days. The capsule thickness, numerical density of inflammatory cells (IC) and fibroblasts (Fb), amount of collagen, immunohistochemistry detection of interleukin‐6 (IL‐6) and osteocalcin (OCN), von Kossa and analysis under polarized light were performed. Data were subjected to two‐way ANOVA followed by Tukey's test (p ≤ 0.05). At 7 and 15 days, the capsules around Bio‐C Pulpo were thicker than in WMTA while, at 30 and 60 days, significant differences were not observed among the groups. Although at 7, 15, and 30 days, a greater number of IL‐6‐immunostained cells was found in Bio‐C Pulpo and Biodentine than in WMTA, no significant difference was detected among the groups at 60 days. In all groups, the number of Fb and collagen content increased significantly over time. The capsules around materials exhibited von Kossa‐positive and birefringent structures, and OCN‐immunostained cells whereas, in the CG, these structures were not observed. Bio‐C Pulpo, similarly to Biodentine and WMTA, is biocompatible, allows the connective tissue repair and presents bioactive potential in connective tissue of rats.
Quantum chemical rovibrational analysis of aminoborane and its isotopologues
Authors: Schneider Moritz , Rauhut Guntram 
Published: May 2022

AbstractAminoborane, H2NBH2 and its isotopologues, H2N10BH2, D2NBD2, and D2N10BD2, have been studied by high‐level ab initio methods. All calculations rely on multidimensional potential energy surfaces and dipole moment surfaces including high‐order mode coupling terms, which have been obtained from electronic structure calculations at the level of explicitly correlated coupled‐cluster theory, CCSD(T)‐F12, or the distinguishable cluster approximation, DCSD. Subsequent vibrational structure calculations based on second‐order vibrational perturbation theory, VPT2, and vibrational configuration interaction theory, VCI, were used to determine rotational constants, centrifugal distortion constants, vibrationally averaged geometrical parameters and (an)harmonic vibrational frequencies. The impact of core‐correlation effects is discussed in detail. Rovibrational VCI calculations were used to simulate the gas phase spectra of these species and an in‐depth analysis of the ν7 band of aminoborane is provided. Color‐coding is used to reveal the identity of the individual progressions of the rovibrational transitions for this particular mode.