bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entomological drivers of uneven malaria transmission in urban lowland areas in Bouaké, Côte d’Ivoire
Authors: Dahoui Milossé MC , Adou Kouassi A , Coulibaly Baba , Niamien Koffi L , Koné Aboubacar , Cornelie Sylvie , Zoh Dounin D. , Assouho Konan F. , Moiroux Nicolas , Adja Akré M , Fournet Florence 
Published: November 2022

Abstract
Background
The use of urban lowlands for agriculture contributes to the food security of city- dwellers, but promotes malaria transmission. The objective of our study was to characterize the entomological drivers of malaria transmission in two lowlands (N’Gattakro and Odiennekourani) in the city of Bouaké, Côte d’Ivoire.
Methods
The human landing catch technique was used to capture mosquitoes in houses located at the edge of two lowlands in Bouaké from February to December 2019. A drone was used to monthly describe the different crops (rice and vegetables) at the parcel level. The different mosquito species were identified morphologically and by PCR analysis for the Anopheles gambiae complex. Anopheles infection by Plasmodium parasites was assessed by quantitative PCR. Mosquito diversity, biting behaviour and rhythm, and malaria transmission were determined in each lowland and compared.
Results
Anopheles gambiae s.l. was predominant in N’Gattakro and Culex quinquefasciatus in Odiennekourani. Four Anopheles species were identified: An. gambiae s.l. and Anopheles funestus in both lowlands, Anopheles pharoensis in N'Gattakro, and Anopheles ziemanni in Odiennekourani. Within the An. gambiae complex, three species were caught: An. gambiae s.s., Anopheles coluzzii, and Anopheles arabiensis for the first time in Côte d'Ivoire (30.1%, 69.9% and 0% in N’Gattakro, and 45.1%, 52.6% and 2.4% in Odiennekourani, respectively). An. gambiae s.l. species exhibited a significant exophagic behaviour in N’Gattakro (77.1% of outdoor bites versus 52.2% in Odiennekourani). In N’Gattakro, 12.6% of captures occurred before bedtime and after waking up, 15.1% in Odiennekourani. The mean human biting rate was higher in N’Gattakro than in Odiennekourani (61.6 versus 15.5 bites per person per night). Overall, Anopheles infection rate was 0.68%, with 0.539 and 0.029 infected bites per person per night in N’Gattakro and Odiennekourani, respectively.
Conclusion
The risk of malaria in urban agricultural lowland areas is uneven. The role of agricultural developments and irrigation patterns in the production of larval habitat should be explored. The exophagic behaviour of Anopheles vectors raises the question of the residual transmission that needs to be assessed to implement appropriate control strategies.
Hemorrhage induced by Thrombolysis: new insights from a real-world pharmacovigilance study
Authors: Guo Kangyuan , Zhang Li , Feng Zhanchun , Xia Xudong , Sun Xiaobo , Yan Ziqi , Jiao Zhiming , Feng Da 
Published: November 2022

Abstract
Background: Hemorrhage represents the most common and serious side effect of thrombolytic therapy. Many studies have compared the risk of bleeding between different thrombolytic therapy, but analysis of time-to-onset for hemorrhage induced by thrombolysis is yet sparse.
Methods: We conducted a retrospective study based on the adverse drug reaction reports on antithrombotic agents collected by the Henan Adverse Drug Reaction Monitoring Center. We assessed the reporting odds ratio to determine the disproportionate reporting signals for bleeding and the Weibull shape parameter was used to evaluate the time-to-onset data.
Results: In the signal detection, crude low molecular weight heparin-hemorrhage was found as a positive signal. The hemorrhage for most antithrombotic agents was random failure profiles. In particular, the hazard of hemorrhage decreased over time for warfarin and clopidogrel and increased for alteplase, nadroparin, and dipyridamole.
Conclusions: We found that the patients taking Crude low molecular weight heparins were more likely to bear hemorrhagic side effects, which may be attributed to the severely irrational use of this medication under improper management. The risk of bleeding decreased over time for warfarin and clopidogrel and increased for alteplase, nadroparin, and dipyridamole.
A Comparison study of different grasses on agronomic performance and chemical composition across three altitudes and harvesting dates in Ethiopia
Authors: Adnew Wubetie 
Published: November 2022

Abstract
One of the major limiting factors of livestock production in Ethiopia is the very low quantity and quality of livestock feeds supplied in the country. This calls for seeking forages that complement poor quality feeds in the country. Hence, this research project was accomplished to comparatively evaluate and find compatible forages among three types of grass. The target of this paper was to compare three types of grass agronomic performance and chemical composition under three different agro-ecologies and three harvesting dates (60, 90, and 120 days). Field experiments were carried out in Tach Gayint (low altitude), Fogera (mid-altitude, and Debre Tabor (high altitude) Districts in 2017/2018. The treatments were laid out in a factorial RCBD (randomized complete block design) with three replications. The treatments contain combinations of 3 altitudes and 3 harvesting dates. Agronomic, yield, and chemical composition data were collected from all treatments in all locations. The collected data were subjected to analysis of variance procedures with a P 0.05 significance test. Altitudes and harvesting dates showed significant effects on the agronomical performance and chemical composition of those 3 types of grass The highest plant height (PH) and dry matter yield (DMY) by Napier and the number of tillers per plant (NTPP) by Mulato II were recorded at all altitudes. Similarly, harvesting dates showed a significant difference (P 0.05) in DMY and CP for all grasses in all studied areas. The significant difference in DMY was increasing as the harvesting date increased, but CP was contrariwise. Although all Napier grass recorded the highest biomass yield in all studied areas and showed high potential as an alternative livestock feed in Ethiopia, the highest crude protein value and the least value of NDF and ADF (best forage quality parameters) were recorded by Mulato II. Thus, the results of this study revealed that Brachiaria hybrid cv. Mulato II has great potential to fulfil the demands for quality feeds for livestock production, especially at low altitudes However, the current result alone might not lead to a final valid conclusion, hence it is recommended to follow up with a further study about feed value experimental using suitable animals.
Tumor immunophenotyping-derived signature identifies prognosis and neoadjuvant immunotherapeutic responsiveness in gastric cancer
Authors: Wang Jia-Bin , Qiu Qing-Zhu , Zheng Qiao-Ling , Zhao Ya-Jun , Xu Yu , Zhang Tao , Wang Shuan-Hu , Wang Quan , Jin Qin-Wen , Ye Yin-Hua , Li Ping , Xie Jian-Wei , Lin Jian-Xian , Lu Jun , Chen Qi-Yue , Cao Long-Long , Yang Ying-Hong , Zheng Chao-Hui , Huang Chang-Ming 
Published: November 2022

Abstract
Background
The effectiveness of neoadjuvant immune checkpoint inhibition (ICI) therapy has been confirmed by clinical trials; however, patients that are suitable for receiving this therapy remain unspecified. Previous studies have demonstrated that the tumor microenvironment (TME) dominates immunotherapy; therefore, an effective classification strategy for the TME is needed.
Methods
Five publicly available datasets (n = 1,426) were used to identify the immunophenotypic features of the TME and to screen for core molecules. The training cohort (n = 506) was used to construct the immunophenotypic score (IPS) and six independent external centers (n = 638) were recruited as validation. Besides, 52 patients with GC receiving neoadjuvant anti-PD-1 therapy was enrolled to explore the value of the IPS in neoadjuvant ICI therapy. Moreover, the IPS-specific TME was profiled by multiplexed immunohistochemical staining and immunohistochemical staining.
Results
Five immunophenotype-related features (WARS, UBE2L6, GZMB, BATF2, and LAG-3) associated with prognosis and the immunotherapeutic response in GC were identified, forming the IPS. The data from seven medical centers (n = 1,144) indicated that the IPS is a robust and independent biomarker for GC and superior to the traditional TNM stage. Furthermore, IPSLow was defined as the immune-activated tumor that benefited from neoadjuvant anti-PD-1 therapy, while IPSHigh exhibited more immune unresponsive signals. Notably, patients with IPSLow and PD-L1 (CPS) ≥ 5 were observed to be the most favorable group for neoadjuvant anti-PD-1 treatment.
Conclusions
The IPS could serve as a valid quantitative tool for immunophenotyping to improve clinical outcomes, and it provides an effective reference for the implementation of neoadjuvant ICI therapy for patients with GC.
Extreme weather events and its impacts on rice production in coastal Odisha region of India
Authors: Vijayakumar S , Nayak A. K. , Manikandan N. , Pattanaik Suchismita , Tripathi Rahul , Swain Chinmaya Kumar 
Published: November 2022

Abstract
The study investigates trend in extreme daily precipitation and temperature over coastal Odisha, India. 18 weather indices (8 related to temperature and 10 related to rainfall) were calculated using RClimDex software package for the period 1980–2010. Trend analysis was carried out using linear regression and non-parametric Mann-Kendall test to find out the statistical significance of various indices. Results indicated, a strong and significant trend in temperature indices while the weak and non-significant trend in precipitation indices. The positive trend in Tmax mean, Tmin mean, TN90p (warm nights), TX90p (warm days), diurnal temperature range (DTR), warm spell duration indicator (WSDI), consecutive dry days (CDD) indicates increasing the frequency of warming events in coastal Odisha. Similarly, positive trend in highest maximum 1-day precipitation (RX1), highest maximum 2 consecutive day precipitation (RX2), highest maximum 3 consecutive day precipitation (RX3), highest maximum 5 consecutive day precipitation (RX5), number of heavy precipitation days (≥ 64.5mm), number of very heavy precipitation days (≥ 124.5mm) and negative trend in the number of rainy days (R2.5mm), consecutive wet days (CWD) indicate changes toward the more intense and poor distribution of precipitation in coastal Odisha. The combined effect of precipitation and temperature extreme events showed negative effects on rice grain yield. With the increasing number of extreme events there was sharp decline in rice grain yield was observed in the same year in all the coastal districts. This study emphasizes the need for new technology/management practice to minimize the impacts of extreme weather events on rice yield.
Towards Safe Patient Identification Practices: the Development of a Conceptual Framework from the Findings of a Ph.D. Project
Authors: De Rezende Helena , Melleiro Marta Maria 
Published: November 2022

Patient identification errors are considered the root cause of other patient safety incidents. Despite the development, recommendation, and application of several initiatives to reduce and prevent misidentification in hospital settings, errors continue to occur. They directly impact the quality of care provided, resulting in delays in care, added costs, unnecessary injuries, misdiagnosis or wrong treatment, and other serious and irreversible types of harm and death. Furthermore, the certainty of the evidence of the effectiveness of interventions to reduce patient identification errors is considered very low.
This paper reports on the development of a conceptual framework for safe practices in the area of patient identification. The proposed conceptual framework was developed based on presuppositions regarding learning health systems and the available evidence from the published systematic reviews of the effectiveness of interventions in reducing patient identification errors in hospital settings. The core circle of the framework represents the partnership between managers, healthcare professionals, patients, and families working toward integrative and collaborative efforts for safe patient identification practices. The inner dimension states the recommendations for practice sustained by applying technological resources and educational strategies to raise awareness of the importance of accurate patient identification and interdisciplinarity, which works as an axis that supports integrated and collective work between healthcare professionals aiming for safe care. The outer dimension represents recommendations for teaching and research to develop effective patient identification practices that can enhance patient safety and the quality of care provided in hospital settings.
This framework provides a valuable method for engaging interdisciplinary teams to improve the safety of patient identification systems.
Principles of Forming a Strategy for Reducing the Psychological Tension of Social Network Users
Authors: Khakimova Aida , Zolotarev Oleg , Zatsman Igor 
Published: November 2022

Aims:
The purpose of the study was to develop principles of a strategy for influencing the psychological state of social network users using the example of the Russian-language segment of Twitter, one of the reasons for which is the lack of awareness about aspects of the coronavirus infection.

Background:
In contrast to the existing works on mood management and Emotion Regulation Strategies, there are principles based not on emotional regulation (cognitive reappraisal and expressive suppression), but on information processing of the content of social media messages and forums.

Objective:
The objective of the study was to develop principles of a strategy for reducing the psychological tension of social network users (further – Strategy) based on the Russian-language segment of Twitter.

Methods:
The proposed research methodology includes a study of the discussion field in the active forum of the Runet (the qualitative aspect of emotionality as a reflection of psychological tension) and the Russian-language segment of Twitter (the quantitative aspect of terminology frequency). The qualitative research consisted in isolating the sensitive words used by vaccine opponents to describe their beliefs. A multi-stage methodology has been developed for the meaningful analysis of Twitter users’ messages.

Results:
. The result of the study is a methodology for developing principles of the Strategy. Based on this methodology, the following aspects of the problem have been developed: 1) the principle of clarifying the definition of psychological tension; 2) the principle of comparing the user and scientific meanings of terms, taking into account the contexts of their use; 3) the principle of contextual comparison of the user’s and scientific meanings of the term; 4) the principle of visual popularization of scientific knowledge.

Conclusion:
An original methodology was created for developing principles of the Strategy. In contrast to the existing works on mood management and Emotion Regulation Strategies, there are principles based not on emotional regulation (cognitive reappraisal and expressive suppression [1]), but on information processing of the content of social media messages and forums.

Other:
A new approach to reducing the psychological tension of social media users can contribute to sharing timely, accurate and positive information about COVID-19, and reduce excessive discussions about COVID-19, which can positively affect the psychological well-being of the general public.
Characterizing the Gaps Between Best-Practice Implementation Strategies and Real-world Implementation: Qualitative Study Among Family Physicians Who Engaged With Audit and Feedback Reports
Authors: Rouleau Geneviève , Reis Catherine , Ivers Noah , Desveaux Laura 
Published: November 2022

Background
In Ontario, Canada, a government agency known as Ontario Health is responsible for making audit and feedback reports available to all family physicians to encourage ongoing quality improvement. The confidential report provides summary data on 3 key areas of practice: safe prescription, cancer screening, and diabetes management.

Objective
This report was redesigned to improve its usability in line with evidence. The objective of this study was to explore how the redesign was perceived, with an emphasis on recipients’ understanding of the report and their engagement with it.

Methods
We conducted qualitative semistructured interviews with family physicians who had experience with both versions of the report recruited through purposeful and snowball sampling. We analyzed the transcripts following an emergent and iterative approach.

Results
Saturation was reached after 17 family physicians participated. In total, 2 key themes emerged as factors that affected the perceived usability of the report: alignment between the report and the recipients’ expectations and capacity to engage in quality improvement. Family physicians expected the report and its quality indicators to reflect best practices and to be valid and accurate. They also expected the report to offer feedback on the clinical activities they perceived to be within their control to change. Furthermore, family physicians expected the goal of the report to be aligned with their perspective on feasible quality improvement activities. Most of these expectations were not met, limiting the perceived usability of the report. The capacity to engage with audit and feedback was hindered by several organizational and physician-level barriers, including the lack of fit with the existing workflow, competing priorities, time constraints, and insufficient skills for bridging the gaps between their data and the corresponding desired actions.

Conclusions
Despite recognized improvements in the design of the report to better align with best practices, it was not perceived as highly usable. Improvements in the presentation of the data could not overcome misalignment with family physicians’ expectations or the limited capacity to engage with the report. Integrating iterative evaluations informed by user-centered design can complement evidence-based guidance for implementation strategies. Creating a space for bringing together audit and feedback designers and recipients may help improve usability and effectiveness.
Healthcare and economic burden of anticholinergic use in adults with overactive bladder: a systematic literature review
Authors: Duperrouzel Corinne , Martin Coby , Mendell Ari , Bourque Megan , Carrera Adam , Mack Alicia , Nesheim Jeffrey 
Published: November 2022

Aim:
To determine the economic burden associated with anticholinergic medication use in adults with overactive bladder (OAB) in the USA.
Methods:
A systematic literature review was conducted to identify articles assessing healthcare resource utilization (HCRU) and costs associated with anticholinergic use in adults with OAB.
Results:
From the 34 articles identified, increased anticholinergic burden, switching anticholinergic treatments and potentially inappropriate anticholinergic use were associated with increased HCRU and/or costs. However, studies comparing patients with OAB receiving anticholinergics to individuals with untreated OAB or without OAB reported a mix of increases and decreases in HCRU and costs.
Conclusion:
Additional controlled studies assessing the economic impact of anticholinergics in OAB are needed and may enable optimization of economic and potentially patient outcomes.
The Effect of Audit Firm Internal Inspections on Auditor Effort and Financial Reporting Quality
Authors: Aobdia Daniel , Petacchi Reining C. 
Published: November 2022

ABSTRACT
We examine the effect of large audit firms’ internal inspection programs, an important monitoring mechanism, on auditor effort and financial reporting quality. Internal inspections are often predictable, and engagement teams concentrate their effort on audits ultimately selected for inspections. The extra effort increases the likelihood of a favorable inspection rating. We find some evidence of improvement in financial reporting quality in the inspection year, suggesting that internal inspections are effective in deterring auditor shirking. Upon receiving a favorable rating, the engagement team reverts audit effort back to the preinspection level. However, if the rating is unfavorable, the team increases effort on future engagements of the client. This higher effort improves the client’s financial reporting quality if the internal inspection program is not deemed deficient by the PCAOB. Collectively, the results highlight the importance of an effective internal inspection program in improving financial reporting quality.
JEL Classifications: M41; M42.
GLP-1 Receptor Agonists and the Risk of Thyroid Cancer
Authors: Bezin Julien , Gouverneur Amandine , Pénichon Marine , Mathieu Clément , Garrel Renaud , Hillaire-Buys Dominique , Pariente Antoine , Faillie Jean-Luc 
Published: November 2022

OBJECTIVE
To determine whether use of glucagon-like peptide 1 (GLP-1) receptor agonists (RA) is associated with increased risk of thyroid cancer.

RESEARCH DESIGN AND METHODS
A nested case-control analysis was performed with use of the French national health care insurance system (SNDS) database. Individuals with type 2 diabetes treated with second-line antidiabetes drugs between 2006 and 2018 were included in the cohort. All thyroid cancers were identified through hospital discharge diagnoses and medical procedures between 2014 and 2018. Exposure to GLP-1 RA was measured within the 6 years preceding a 6-month lag-time period and considered as current use and cumulative duration of use based on defined daily dose (≤1, 1 to 3, &gt;3 years). Case subjects were matched with up to 20 control subjects on age, sex, and length of diabetes with the risk-set sampling procedure. Risk of thyroid cancer related to use of GLP-1 RA was estimated with a conditional logistic regression with adjustment for goiter, hypothyroidism, hyperthyroidism, other antidiabetes drugs, and social deprivation index.

RESULTS
A total of 2,562 case subjects with thyroid cancers were included in the study and matched with 45,184 control subjects. Use of GLP-1 RA for 1–3 years was associated with increased risk of all thyroid cancer (adjusted hazard ratio [HR] 1.58, 95% CI 1.27–1.95) and medullary thyroid cancer (adjusted HR 1.78, 95% CI 1.04–3.05).

CONCLUSIONS
In the current study we found increased risk of all thyroid cancer and medullary thyroid cancer with use of GLP-1 RA, in particular after 1–3 years of treatment.