bluuebunny/crossref_metadata_2025_split huggingface dataset:
CLINICAL METHODS OF EXAMINATION OF PATIENTS WITH CHRONIC DISEASES OF THE MUCOSA IN THE PROVISION OF ORTHOPEDIC TREATMENT
Authors: Yagmurov Haidar , Borisova Eleonora 
Published: May 2022

Chronic diseases of the oral mucosa are difficult for a dentist to diagnose and treat. The recurrent course of chronic diseases of the oral mucosa leads to the fact that patients are left without orthopedic dental care for a long time. Recent studies have shown that orthopedic treatment of patients with chronic diseases of the oral mucosa is not only possible, but also necessary. If a pathology of the oral mucosa is detected during orthopedic treatment, it is necessary to conduct a complete examination of the patient, obtain advice from specialist doctors: a dental surgeon, dermatologist, endocrinologist, infectious disease specialist, etc., and draw up a joint treatment plan. Under our supervision were 69 patients, of both sexes, aged 58 to 78 years, during the examination of which special attention was paid to the study of the oral mucosa. Particular attention was paid to the study of the oral mucosa, especially changes in the background of chronic diseases of the oral mucosa. During her examination, the color was noted (taking into account the patient's age and profession), the degree of moisture, swelling, the presence of pathological formations, their shape, size, quantity, localization, location of elements on the changed or normal color of the mucosa. The condition of the gums, the mucous membrane under the prosthesis was taken into account. Palpation determined the density of soft tissues, the sensitivity of pathological changes in the mucous membrane to pressure and friction, the presence of pain points. The general characteristics of the mucous membrane of the prosthetic bed were evaluated according to the Supple classification. After applying the prosthesis, the state of the mucous membrane of the prosthetic bed was assessed in dynamics: on the first, third, seventh and 21st day after prosthetics. Cytological and bacteriological studies were carried out. It was revealed that the erythrocyte sedimentation rate and leukocyte formula, blood test for vitamin D content, the content of immunoglobulins IgA, IgG, were changed compared to the norm.
Prosthetics with removable orthopedic structures are started after a comprehensive examination of patients with an absolute absence of contraindications during the period of remission of chronic diseases of the oral mucosa or during the treatment of the underlying somatic disease.
PREDICTIVE FACTORS AND MECHANISMS OF THEIR IMPLEMENTATION IN THE DEVELOPMENT OF PRECANCEROUS AND ONCOLOGICAL DISEASES OF THE ORAL MUCOSA
Authors: Zaitseva Maria , Nagaeva Marina , Chekina Anna 
Published: May 2022

The problem of oncological and precancerous diseases of the oral mucosa is urgent, because the prevalence of these diseases is high, as well as malignant neoplasms of this localization are among the most aggressive and difficult to treat human neoplasms, characterized by a high percentage of mortality.
These facts determine the increased importance of primary prevention of precancerous and cancerous diseases, the purpose of which is to identify and eliminate predictive factors of the development of these pathologies.
Objective of the study is to conduct a systematic analysis of modern Russian and foreign literary sources in the aspect of predictive factors of the occurrence of precancerous and cancerous diseases of the red border of the lips and oral mucosa and their main mechanisms.
Methodology. The research is based on the search and analysis of modern Russian and foreign original sources on the topic in the databases eLibrary, Pubmed, Crossref.
Results. The development of precancerous and oncological diseases is a complex multifactorial process that proceeds under the influence of a number of prognostic factors that have both isolated and synergistic effects on the human body at the local or general level.
Conclusion. We have analyzed the scientific literature, which indicates a significant contribution of a wide range of modifiable and unmodifiable factors in the development of precancerous and oncological processes. Identification and correction of probable risk factors for the occurrence of precancerous and oncological diseases of the oral mucosa can help prevent the development of these diseases.
ANALYSIS OF THE EFFICACY OF THE USE OF THERAPEUTIC AND PREVENTIVE MEDICINES IN PATIENTS WITH A LABORATORY-CONFIRMED DIAGNOSIS OF SARS-COV-2
Authors: Nasibullina Alisa , Kabirova Milyausha , Kabirov Il'dar 
Published: May 2022

To date, there is a limited amount of literature that describes the use of oral therapeutic and prophylactic drugs in patients with a confirmed diagnosis of SARS-CoV-2. Therefore, this topic is relevant. Thus, the purpose of this study was to study the effectiveness of the use of therapeutic and prophylactic agents in patients with a laboratory-confirmed diagnosis of mild to moderate SARS-CoV-2, with or without concomitant oral co-infection.
The data of the conducted study will constitute an important stage in the algorithm of specialized therapy.
Materials and methods. A comparative analysis of the use of therapeutic and prophylactic agents for the oral cavity in patients with a confirmed diagnosis of SARS-CoV-2 was carried out. The conclusions are based on the results of a clinical study that compared the effectiveness of the use of therapeutic and prophylactic agents in 90 patients aged 20 to 87 years with mild to moderate Sars-CoV-2 with oral co-infection and 15 patients aged from 20 to 87 years of age with mild to moderate Sars-CoV-2 without coinfection.
Results. During the study, the following results were obtained. The most effective drug was a solution of aqueous chlorhexidine 0.5%, but there was a side effect in the form of xerostomia. The Miramistin solution also had high efficiency, and the lowest efficiency was observed when using the Rotokan solution.
Conclusions. The data of the conducted study will constitute an important stage in the algorithm of specialized therapy.
PROCESSING OF CBCT DATA WITH ARTIFICIAL INTELLIGENCE IN THE DIAGNOSIS OF CARIES AND ITS COMPLICATIONS
Authors: Khabadze Zurab , Makeeva Irina , Mordanov Oleg , Nazarova Daria 
Published: May 2022

Over the past few years, artificial intelligence (AI) technologies have been actively used in many areas of medicine, including dentistry.
The aim of the study is to determine the diagnostic value of IS in the detection of caries and its complications according to cone beam computed tomography (CBCT) data in comparison with clinical examination.
Materials and methods. CBCT images of 15 patients with carious and periodontal lesions were analyzed by an experienced dentist, who also specializes in radiology, and the Diagnocat AI software. The dentist also performed a visual examination of these patients.
Results. Most of all contact caries were determined using AI (n = 20), and occlusal caries − during clinical examination (n = 10). The greatest number of periapical changes was also detected using IS (n = 22). The difference between the indicators of detection of pathological foci in the assessment of IS and the radiologist was statistically insignificant, which indicates the equivalence of these methods. X-ray image evaluation revealed more contact caries compared to clinical examination (14 vs. 7, p < 0.05), but clinical examination was superior in detecting occlusal caries (10 vs. 2, p < 0.03). Periodontal disease was more accurately diagnosed by X-ray (17 vs. 9, p < 0.05). The average time for evaluation of CBCT images by a radiologist was 21.54 ± 4.4 minutes, and the AI completed the report in 4.6 ± 4.4 minutes from the moment the loading of CBCT was completed (p < 0.01).
Conclusion. The use of AI technologies in the analysis of CBCT images can improve the accuracy of diagnosing caries and its complications by up to 98%, as well as significantly speed up the time for making a diagnostic decision.
Orchid Distribution along the Elevation Gradient in Panchase Forest Conservation Area of Gandaki Province, Nepal
Authors: Rai Alisa , Khadka Udhab R. , Limbu Dil K. , Shakya Lokesh R. 
Published: May 2022

The vegetation composition and elevation play a key role in the distribution of plants. Among the flowering plants, orchids are widely distributed beautiful flowers having ornamental and medicinal values. The Panchase Forest Conservation Area is one of the hot spots for the orchids, a threatened group of the flowering plants. The preceding studies on orchids seem usually focused on documentation of the orchid species and their medicinal values showing no works on orchid species distribution along the elevation gradient and aspects. Therefore, this research was concentrated on assessing orchid distribution along the elevation in the forest of the Middle-mountain. The study was conducted in former Chapakot and Bhadaure-Tamagi Village Development Committees that lie in Pokhara Metropolitan City-23 and Annapurna Rural Municipality-4, Kaski District. Chapakot represents south-west (SW) aspect and Bhadaure-Tamagi represents north-west (NW) aspect. For this study, the belt-transect method with 20 m x 20 m quadrat size at an interval of 100 m elevation was used for assessing the orchid richness along elevation and aspects. Altogether, 61 orchid species, with Eria, Dendrobium, Cymbidium and Bulbophyllum as the most common genera, were found. Among the orchid species, Dendrobium gibsonii was not reported in earlier studies from Panchase area. The orchid richness varied along the elevation and aspect. The SW aspect showed fluctuation in orchid richness, whereas the NW aspect showed humped shaped pattern. Further detailed studies on factors causing distribution of orchids and their relationship with host species need to be conducted for the conservation of orchids in the Panchase Forest Conservation Area.
Detection of Chilling Injury Symptoms of Salak Pondoh Fruit during Cold Storage with Near Infrared Spectroscopy (NIRS)
Authors: Mardjan Sutrisno Suro , Indriyantoro Jeri 
Published: May 2022

One of the treatment methods that is suitable for maintaining the quality of salak pondoh fruit is cold storage. However, cold storage of salak pondoh fruit below its optimum storage temperature (15°C) can cause chilling injury/CI. This research aims to develop a non-destructive method of determining the CI symptoms of salak pondoh fruit during storage at 5°C with NIRS. Measurements were carried out for 14 days by measuring the CI parameters (pH and IL/ion leakage) and the NIR reflectance spectra. The best PLS method NIR calibration model for estimating pH was generated using the Savitzky-Golay Smoothing pretreatment with rk= 0.81, rv =0.76, SEC= 0.12%, SEP =0.12%, CV= 2.97%, RPD= 1.66, and consistency =100.06%. The IL slope of salak pondoh fruit correlated with the pH in a linear pattern relationship with the equation y = 0.1735x - 0.4305. The highest IL slope value was obtained on the 4th day of storage which means that IL has reached its peak, and CI was predicted to have occurred on the 4th day of storage.
HMMR potential as a diagnostic and prognostic biomarker of cancer - Speculation based on a pan-cancer analysis
Authors: Shang junyi , Qi Yong 
Published: May 2022

Abstract
The status of universal upregulation for the Hyaluronan-Mediated Motility Receptor (HMMR) in pan-cancer is unknown. The aims of our study included: exploring HMMR expression in different tumor types using The Cancer Genome Atlas (TCGA) or other public databases for a pan-cancer analysis, exploring the relationship between HMMR and tumor prognosis, and exploring the role of HMMR in tumor immunity. No matter the pairing or unpairing of data, HMMR expression generally increased as compared to corresponding normal tissue. Based on a CCLE study, our results indicated that HMMR is widely expressed in a variety of tumor cells. For most tumor types, high HMMR expression was associated with reduced Overall Survival (OS), Return to Functional Status (RFS), and Platinum Free Interval (PFI). ROC curves indicated that HMMR displays a high degree of prediction potential for most tumor types. In pan-cancer, HMMR is correlated with some clinical staging, immune cells, and immune checkpoints for some tumors. The results of the GO/KEGG enrichment analysis for proteins most closely related to HMMR, indicating that the most highly enriched pathways are all related to tumor development.
Techniques on endoscopic resection of large thyroid nodules by areola approach
Authors: xiang dapeng , fu lei , wang chengchen , li zhiyu 
Published: May 2022

Abstract
Purpose: Endoscopic thyroidectomy via areola approach (ETA) is a safe and efficient procedure in treating thyroid nodule. However, reports on large nodules(>6cm) resection via ETA are rare. Methods: Between February 2021 and October 2021, five continuous female patients with thyroid nodules larger than 6cm underwent endoscopic thyroidectomy via ETA. The surgical techniques were elaborated and major clinical characteristics including nodule size, operation time and blood loss were analyzed. Results: All the nodules were resected successfully via ETA. All patients were female with an average age of 33 ± 9 yrs. The average largest diameter of the nodules was 6.6±0.4 cm. All patients underwent thyroid lobectomy. The average operation time was 122 ± 8 min . The average blood lost was 17± 4 ml. One patient had transient recurrent laryngeal nerve (RLN) palsy. No patient underwent a conversion to open surgery. All patients were satisfied with the cosmetic Result. Conclusion: ETA is a safe and feasible option for patients with thyroid nodule larger than 6cm. With cautious selection, large nodules could be safely and efficiently resected via ETA.
Strategies of diagnosis and treatment for patients with diabetic foot ulcer during coronavirus disease (COVID-19) pandemic
Authors: Zhang Jinying , Lin Jiayu 
Published: May 2022

Abstract
Background
The coronavirus disease 2019(COVID-19) pandemic is breaking out and rapidly spread across the country, which is also a severe ordeal for medical workers, and the traditional treatment strategy of diabetic foot ulcer (DFU) is also facing challenges.
Methods
We herein report four patients with diabetic foot ulcers during the COVID-19 pandemic who achieved individual diagnosis and treatment plan, made patients get timely and reasonable treatment on the premise of prevention and control. After treatment, the wound healed, and the foot function recovered.
Results
After treatment, the wound healed, and the foot function recovered.
Conclusions
According to the guidelines of relevant domestic experts, this paper recommends reasonable recommendations for the diagnosis and treatment of diabetic foot ulcers, optimizing the diagnosis and treatment process, and reducing cross-infection in the hospital.
Leadership role and professional development of technology
Authors: Uzorka Afam , Olaniyan Ademola Olatide 
Published: May 2022

Abstract
The Covid-19 pandemic has indeed driven educational technology to the next higher level, especially in faculty teaching and research. There is an increasing need for faculty to embrace new technology, especially with the emergence of new normal in both teaching, learning, and research. To become conversant with the technologies, educators need opportunities for professional development. And to continue to be involved with new and evolving technologies in education, faculty members seek leadership and support. This study was carried out to investigate the leadership role in the professional development of technology in the educational delivery system of Nigerian universities. The study adopted a qualitative approach. This qualitative study randomly selected a convenience sample of 100 faculty and administrators in the faculty of education of 12 universities in Nigeria. Using focus-group discussion sessions, interviews, the researchers met with 100 participants in groups of 10 to 15 each session. Data were transcribed and entered into a database for analysis. The leadership role of faculty members, technology specialists, policy, support, and infrastructure were discussed. The study shows that to help faculty members lead the way in investigating, integrating, and evaluating technologies, faculty members need policies and leadership support, equitable access to technology, support, professional development, and recognition.
Lung Ultrasound Targeted Recruitment (Lustr): a Novel Protocol to Optimize Open Lung Ventilation in Critically Ill Neonates
Authors: Chioma Roberto , Amabili Lorenzo , Ciarmoli Elena , Copetti Roberto , Villani Pier Giorgio , Natile Miria , Vento Giovanni , Storti Enrico , Pierro Maria 
Published: May 2022

Abstract
PurposeThe objective of this study was to investigate the effectiveness of an original Lung UltraSound Targeted Recruitment (LUSTR) protocol to improve the success of lung recruitment maneuvers (LRMs), performed as a rescue approach in critically ill neonates, as compared to the standard oxygenation-guided LRM. MethodsAll the LUSTR maneuvers, performed in infants with oxygen saturation/fraction of inspired oxygen (S/F) ratio below 200, were included in this case-control study (LUSTR-group). The LUSTR-group was matched by the initial S/F ratio (which is inversely proportional to the severity of the respiratory insufficiency) and underlying respiratory disease with a control group of lung recruitments performed following the standard oxygenation-guided procedure (Ox-group). The primary outcome was the improvement of the S/F ratio (Delta S/F) throughout the LRM. Secondary outcomes included the variation of the Oxygen Saturation Index (OSI) and the rate of air-leaks.ResultsEach group was constituted of fourteen LRMs. As compared to the standard approach, the LUSTR protocol was associated with a higher success of the procedure in terms of delta S/F (110±47.3 vs 64.1±54.6, p = 0.02), and delta OSI (8.2±6.8 vs 2.8±2.2, p = 0.01). These results remained significant after adjusting for confounding variables through multiple linear regressions. All the LRMs in the LUSTR group obtained the sonographic resolution of the lung derecruitment. Patient position before and during LRM was modified more frequently in the LUSTR group. The incidence of pneumothorax was lower, although not reaching statistical significance, in the LUSTR-group (0 vs 14.3%, p = 0.15).ConclusionThe LUSTR protocol may be a more effective and potentially safer option than the oxygenation-based procedure to guide open lung ventilation in neonates.
Comparative Analysis of Bioaccumulation of Cadmium, Lead, Chromium, Copper and Nickel in Wheat Crop
Authors: Mazhar Muhammad Waqar , Irfan Muhammad , Raza Ahmad , Tahir Hira , Mazhar Fatima 
Published: May 2022

Abstract
In this research, the comparative analysis of heavy metals has been studied. An experiment was conducted to determine heavy metals bioaccumulation in wheat as wheat is the staple cereal crop consumed as food globally. Abiotic stress disturbs the metabolic pathway of plants, and the bioaccumulation of the metals cause enzymatic degradation, reduction in photosynthesis, increased level of the ROS species. Comparative analysis of the Cd, Pb, Cr, Cu, and Ni was analyzed with the help of Inductively Coupled plasma optical emission spectrometry (ICP-OES). The results show that Ni has a maximum value of BCF in shoots and roots, whereas the Cr has maximum TF values. SOD and POD assays were performed to check the ROS level in the plants. The results show that plants increase their anti-oxidant enzymes for the scavenging of ROS produced against the bioaccumulation of heavy metals.
A novel design for glucose detection in urine samples using SPR sensor
Authors: Karki Bhishma , Jha Ankit , Pal Amrindra , Srivast Vivek 
Published: May 2022

Abstract
A multilayer SPR based sensor is proposed to detect glucose in the urine using nanolayers of silver, MXene, ZnO, and graphene placed over coupling BK7 prism. The performance of the proposed sensor has been computed for sensitivity, full width half maximum, quality factor, and signal to noise ratio. The value of sensitivity for glucose concentration in urine for 0−15 𝑚𝑔/𝑑𝐿 is computed as 123 𝑑𝑒𝑔/𝑅𝐼𝑈, for 0.625 𝑔/𝑑𝐿 its value is 131 𝑑𝑒𝑔/𝑅𝐼𝑈 and similarly for 1.25 𝑔/𝑑𝐿, 2.5 𝑔/𝑑𝐿, 5 𝑔/𝑑𝐿 and 10𝑔/𝑑𝐿 it has been computed as 126 𝑑𝑒𝑔/𝑅𝐼𝑈, 132 𝑑𝑒𝑔/𝑅𝐼𝑈, 132.33 𝑑𝑒𝑔/𝑅𝐼𝑈 and 133.5 𝑑𝑒𝑔/𝑅𝐼𝑈 respectively. The corresponding computed values for full width half maximum, quality factor are 3.35 𝑑𝑒𝑔, 3.37𝑑𝑒𝑔, 3.39 𝑑𝑒𝑔 , 3.41𝑑𝑒𝑔, 3.48 𝑑𝑒𝑔, 3.64 𝑑𝑒𝑔 and 36.6 𝑅𝐼𝑈−1,38.7 𝑅𝐼𝑈−1, 37 𝑅𝐼𝑈−1, 38.6 𝑅𝐼𝑈−1, 37.9 𝑅𝐼𝑈−1, 37.4 𝑅𝐼𝑈−1 respectively. The advancement in performance of the proposed SPR sensor makes it a suitable structure for glucose detection in urine samples, extending its use in the medical field.
‘After mealtime is before mealtime’ – An ethnographic exploration of nursing home residents' practices of dealing with meal requirements
Authors: Stöhr Doreen , Mayer Hanna , Ammann Eva Soom 
Published: May 2022

Abstract
Background: In nursing homes, food is part of the care provided to residents, causing it to be strictly organised within the institutional framework. Moreover, once food has been integrated into the institutional logic, structural and economic aspects regarding organisation of food and eating may dictates individual and social needs, as a theoretical perspective informed by Goffman's notion of the 'total social institution' suggests. This paper describes nursing home residents' practices of dealing with meal requirements in two Austrian nursing homes, to understand how food integrates into the daily routine and how the institutional setting influences the social and material arrangement of food. Methods: An ethnographic design was chosen to gain an in-depth understanding. Two urban nursing homes were studied over 21 months (approx. 800 hours of participant observation and ethnographic interviews collected). Data analysis took place iteratively, following Grounded Theory strategies.Results: As our rich descriptions from this procedure show, observing everyday practices of eating in nursing homes reveals complex dimensions of residents being subject to institutional logics, and also demonstrates that residents develop elaborate strategies to deal with the institutional circumstances. Conclusions: The resulting tensions between the restrictions of living in a formal organisation and the agencies of residents described, may contribute to better understanding the effects of structural constraints and to designing more flexible processes.