bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan Kegiatan Menggambar, Melipat, Menempel (3M) Untuk Meningkatkan Kemampuan Seni Rupa Anak Kelompok B TK AGAPE
Authors: Salindeho Shinta Christina , Kustiawan Usep , Maningtyas Rosyi Damayani Twinsari 
Published: June 2022

Abstract: This research aims to improve the fine arts skills of children in group B of AGAPE Kindergarten by implementing 3M activities (drawing, folding, sticking). This research uses the CAR research method (Classroom Action Research). The results showed that the application of 3M activities (drawing, folding, sticking) could improve children's art skills as evidenced by an increase from the first cycle of 55.23 percent to 76.19 percent in the second cycle. Based on the presentation of the results of increasing children's art skills with 3M activities from cycle I to cycle II, it was 20.95 percent.
Abstrak: Penelitian ini bertujuan untuk meningkatkan kemampuan seni rupa anak kelompok B TK AGAPE dengan penerapan kegiatan 3M (menggambar, melipat, menempel). Penelitian ini menggunakan metode penelitian PTK (Penelitian Tindak Kelas). Hasil penelitian menunjukkan bahwa penerapan kegiatan 3M (menggambar, melipat, menempel) dapat meningkatkan kemampuan seni rupa anak terbukti dengan adanya peningkatan dari siklus I sebesar 55,23 persen menjadi 76,19 persen pada siklus II. Berdasarkan pemaparan hasil peningkatan kemampuan seni rupa anak dengan kegiatan 3M dari siklus I ke siklus II sebesar 20,95 persen.
Manajemen Sistem Kredit Semester untuk Mengoptimalkan Perkembangan Potensi Peserta Didik di Sekolah Menengah Atas
Authors: Riani Kinanthi Puspa , Supriyanto Achmad , Zulkarnain Wildan 
Published: June 2022

Abstract: The purpose of this study is to provide information management of semester credit system at senior high school. This research used the qualitative approach with case studies. Data collection techniques in the form of interviews, observation and documentation. The process of data analysis are data condensation, data display, and conclusion drawing/verifications. The results of this study: (1) SKS refers to the constitution of Sisdiknas law number 20 of 2003 and Permendikbud law number 158 of 2014, (2) Deputy head of curriculum do the mapping on selection of students through academic and psychological test, (3) formed the team of SKS, (4) learning in the form of groups and minimize methods lectures, (5) intercultural learning through evaluation review teacher, supervision by means of face to face, and the implementation of the exam for students, (6) found a distribution in UKBM too late and (7) be solved by training or workshop, (8) the output of the program among other students are able to graduate within two years and be able to compete to get into college.
Abstrak: Tujuan penelitian ini adalah memberikan informasi manajemen SKS di SMA. Penelitian ini menggunakan pendekatan kualitatif dengan studi kasus. Teknik pengumpulan data berupa wawancara, observasi dan dokumentasi. Proses analisis data dengan data condensation, data display, dan conclusion drawing/verifications. Hasil penelitian ini: (1) SKS mengacu pada UU SISDIKNAS Nomor 20 Tahun 2003 dan Permendikbud Nomor 158 Tahun 2014, (2) Waka Kurikulum melakukan pemetaan pada seleksi peserta didik melalui tes akademik dan psikologi, (3) terbentuk tim penanggungjawab SKS, (4) pembelajaran dalam bentuk kelompok dan meminimalisir metode ceramah, (5) evaluasi melalui review pembelajaran antar guru, supervisi dengan cara face to face, dan pelaksanaan ujian untuk peserta didik, (6) ditemukan hambatan pendistribusian UKBM yang terlambat dan (7) diselesaikan dengan training atau workshop, (8) output program antara lain peserta didik mampu lulus dalam jangka waktu dua tahun dan mampu bersaing untuk masuk ke perguruan tinggi.
Epidemiological and Clinical Characteristics of Shoulder Dislocations in Emergency Care Settings in Turkey: A Single-Center Experience
Authors: ÇETİN Murat , BIÇAKÇI Nurcan , BIÇAKÇI Sercan , CUNNINGHAM Neil J 
Published: June 2022

Objective: This study evaluated the general epidemiological and clinical characteristics of patients admitted to the emergency department with shoulder dislocations.
Methods: This is a retrospective cross-sectional study, conducted as a chart review at the Emergency Department of the *** State Hospital between 01 January 2018 to 31 December 2019.
Results: A total of 165 patients (median age 50 years and 60% of males) with anterior shoulder dislocations were included. The most common mechanism was traumatic dislocation (65.5%), the primary maneuver of treatment was traction/countertraction (80.6%), and 22.4% were recurrent dislocations. Males were younger and had more spontaneous dislocations. Also, patients with spontaneous dislocations were younger and predominantly males, and tended to be recurrent dislocations than traumatic ones.
Conclusions: Epidemiological characteristics of our patients were similar to a previous study conducted in Turkey, but slightly different from the studies in other populations. Further studies evaluating the incidence and long-term follow-up data are also needed to better elucidate the epidemiological features of shoulder dislocations.
Autoimmune hepatitis, Primary sclerosing cholangitis, and Non-alcoholic steatohepatitis cirrhosis may be more predisposed to the development of hepatocellular carcinoma
Authors: Khajehahmadi Zohreh , Tavilani Heidar , Karimi Jamshid , Rafiee Mohammad , Sadeghabadi Zahra Arab , Mohseni Roohollah , Mohagheghi Sina 
Published: June 2022

Abstract
Background. The effect of cirrhosis etiology on the development of HCC is unclear. The study of the main indicators of cell proliferation and also apoptosis in cirrhotic tissues with different etiologies may declare which one of the cirrhosis etiologies more predispose to the development of HCC. The present study aimed to investigate the gene expression of p53, AMPK and pAMPK protein expressions and the AgNOR features in cirrhotic livers with different etiologies, livers with simple steatosis, and controls.Methods. AMPK and pAMPK protein levels, p53 gene expression, and also AgNOR features were studied in livers with NASH(n=15), HBV/HCV(n=14), AIH(n=15), PSC(n=15), and alcohol(n=9) cirrhosis, 15 livers with simple steatosis, and 15 control using the western blot and quantitative real-time polymerase chain reaction and silver nitrate staining analyses, respectively.Results. The protein levels of AMPK and pAMPK were significantly increased in all cirrhotic groups and were slightly decreased in livers with simple steatosis. The mRNA level of p53 and AgNOR features including total AgNOR number(TAN), total AgNOR length(TAL), and total AgNOR area(TAA) were significantly and simultaneously increased in tissues with NASH, PSC, and AIH cirrhosis and a significant positive correlations were observed between the mRNA level of p53 and the AgNOR features in all cirrhotic tissues. Conclusions. The increased levels of AMPK and pAMPK could be a general response to the most common causes of liver diseases. Likely, patients with AIH, PSC, and NASH cirrhosis predispose to the development of HCC more than patients with viral and alcoholic cirrhosis.
Disseminated intravascular coagulopathy secondary to type I endoleak case report: challenges in diagnosing and managing overlapping symptoms in end-stage renal disease
Authors: Dong Yutong , Cherkasova Julia 
Published: June 2022

Abstract
Introduction: Endoleak-associated DIC is an understudied condition with potentially overlapping symptoms that can increase difficulty of diagnosing and managing patients, especially in patients with comorbid conditions such as renal failure. Case report: A 79-year-old female with significant past medical and surgical histories of stage V chronic kidney disease and abdominal aortic and right external iliac artery aneurysms status-post endovascular presented to an academic hospital for urgent dialysis catheter placement due to end-stage renal disease (ESRD) with symptoms of hypervolemia, electrolyte abnormalities and pancytopenia. Nephrology was consulted on admission. Temporary catheter was placed without complication however patient continued to bleed from that site. Initially, there was suspicion for uremic thrombocytopenia; however, despite tolerating multiple dialysis sessions, patient continued to bleed even after receiving platelet transfusions. Vascular surgery was unable to stop the bleeding. Additional workup revealed abnormal coagulation panel, including low fibrinogen. Hematology was consulted, concerning for possible malignancy, immune thrombocytopenic purpura, or disseminated intravascular coagulopathy (DIC). CT abdomen revealed type I endoleak (6.5cm in diameter) at proximal bilateral common iliac arteries. Cryoprecipitate was given due to low fibrinogen, secondary to endoleak-associated DIC. The bleeding subsequently stopped and patient was discharged with appropriate outpatient appointments including dialysis and vascular surgery. Conclusion: which has overlapping symptoms with many diseases in ESRD patients.
Group decision-making with hesitant fuzzy preference relations considers the best and worst indexes
Authors: Li Jian , Niu Li-li , Chen Qiongxia , Li Feilong , Wang Zhong-xing 
Published: June 2022

Abstract
To address the situation where the Multi-criteria decision-making (MCDM) problems with hesitant fuzzy preference relations (HFPRs), this study develops group decision-making considering the best and worst indexes simultaneously. First, the concepts of best and worst multiplicative consistency indexes of HFPRs are proposed, and then the concept of acceptable multiplicative consistent HFPRs is developed, which takes into accounted best consistency index (BCI) and worst consistency index (WCI). Second, several optimization models are constructed for improving the consistency of HFPRs when they are unacceptable. The main characteristic of the constructed optimization models is that two predefined thresholds for the BCI and WCI are taken into accounted. It requires all the fuzzy preference relations (FPRs) derived from original HFPRs meet the threshold of WCI, and there is a FPR meets the threshold of BCI. Third, the proposed consistency checking and improving processes are extended to incomplete evaluation information. Fourth, an algorithm is designed for deriving priority weights from acceptable consistent HFPRs/incomplete HFPRs. Finally, an illustrative example in conjunction with comparative analysis is used to demonstrate the proposed method is feasible and efficiency for practical MCDM problems.
Madhuca longifolia – bark and leaves: An outlook for natural therapeutic approach for Alzheimer’s disease
Authors: Keri Rangappa S. 
Published: June 2022

Abstract
Alzheimer's disease (AD) is a neurological related disease and it is most common cause for dementia. Also, AD causes many disability and important socio-economic burden, but till to date no cure available. Due to the side effect of commercial available drugs, people more interested for natural origin medicine for drug candidates that are capable of preventing and treating AD related pathology, particularly where suppression of amyloid accumulation, neurofibrillary tangle formation, neuroinflammation and oxidative stress are equally significant. Madhuca Longifolia (Koenig) j.f Macb. is a medicinally very important plant belongs to the family Sapotaceae and commonly known as Mahua/Butter nut tree. It is a multipurpose forest tree that provides food, fodder, fuel, and medicines. It exhibited numerous biological/pharmacological properties including antioxidant, antidepressant, sedative, aphrodisiac, analgesic, tonic, astringent, demulcent, anti-inflammatory, antiproliferative, antimicrobial anti-diabetic, and anti-ulcer activities. In this context, we have collected the leaves and bark of M. longifolia and extracted them from different solvents and further these extracts evaluated the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities, antioxidant studies, and amyloidogenic inhibition supported by thioflavin-T (Th-T) assay (with Cu and Zn), transmission electron microscopy (TEM), inhibition of glycation and aggregation of bovine serum albumin induced by ribose and cell toxicity in SH-SY5Y studies. The results showed that, M. longifolia extracts was able to inhibit the Aβ42 aggregation from monomers and oligomers. Also, able to dis-aggregate the pre-formed fibrils and also it has potent anti-cholinergic and antioxidant activity. The study provides an insight on finding new natural products for AD therapeutics.
A novel disposable self-inserted vaginal device for the non-surgical management of pelvic organ prolapse: Efficacy, safety, and quality of life
Authors: Ziv Elan , Erlich Tsvia 
Published: June 2022

Abstract
Background: We evaluated a novel disposable, collapsible, ring-shaped vaginal device that is self-inserted within an applicator and removed with a string. The device was developed to overcome the drawbacks of existing ring pessaries for non-surgical pelvic organ prolapse management (POP).Methods: The primary objective efficacy endpoint of this prospective, interventional, multicenter, self-controlled, and home-use study was the proportion of subjects with improved staging on the Pelvic Organ Prolapse Quantification (POP-Q) scale. Subjective efficacy was assessed using the POP symptoms alleviation score. Safety was evaluated by recording the rate and incidence of adverse events (AEs) in a daily diary, and quality of life (QoL) was evaluated using the modified Pelvic Floor Impact (PFIQ-7) and Pelvic Floor Disability Index (PFDI-20) questionnaires.Results: A total of 94 usage cycles were observed in a group of 52 participants (mean age 60.2 ± 10.5 years, 81.1% postmenopausal) who used the device for 3558 days. Of these, 24 participants completed one usage cycle, 14 completed two usage cycles, and 14 completed three usage cycles with 28–45 days of ProVate use in each usage cycle. All patients experienced greater than two POP-Q stage reductions. The descent was completely reduced to POP-Q stage 0 in 97.8% of participants. The POP symptom alleviation questionnaire showed significant subjective efficacy (P < 0.0001). The modified PFDI-20 and PFIQ-7 scores also improved substantially (P < 0.0001 for both). There were 91 nonserious device-related AEs: 98.9% were mild and 87.9% anticipated, with no vaginal infection, and one case of urinary tract infection.Conclusion: The novel device substantially reduces prolapse and provides significant subjective POP symptom relief and QoL improvement, with minimal AEs. The device may enable women to self-manage their prolapse with a small, disposable device that minimizes self-touching and frequent dependency on the clinic.Trial registration: Clinical.Trials.gov, NCT02239133, posted September 12, 2014 (retrospectively registered) URL: https://www.clinicaltrials.gov/ct2/show/NCT02239133?term=NCT02239133&draw=2&rank=1
Redox-dependent Structural Origin of the Temperature Threshold and Sensitivity in the TRPV3 Bio-thermometer
Authors: Wang Guangyu 
Published: June 2022

Abstract
The DNA hairpin with a limited size is sensitive to temperature. However, it is unclear if thermosensitive TRP channels also use the temperature-dependent little hairpin sizes to govern their temperature thresholds and sensitivity. Here, graph theory was used as a novel tool to test this hypothesis by analyzing the redox- and state-dependent cryo-electron microscopy structures of TRPV3 with or without the Y564A mutation at different temperatures. The results showed that the biggest little hairpin with the minimum topological loop size and strength control the temperature threshold while a change in the total minimum little hairpin sizes upon a change in the total non-covalent interactions along the channel gating pathway governs the temperature sensitivity. This size- and strength-dependent hairpin thermodynamics may tune the thermal activity and sensitivity of biological macromolecules.
Gut microbiota associated with obesity and high carotid intima-media thickness among Chinese children
Authors: Sun Jiahong , Jin Xuli , Yang Liu , Ma Xiaoyun , Xi Bo , Song Suhang , Zhao Min 
Published: June 2022

Abstract
Background
High carotid intima-media thickness (cIMT) in childhood, usually combined with obesity, is an early predictor of cardiovascular disease (CVD) later in life. However, the association between gut microbiota and high cIMT among children with obesity remains unclear. Therefore, we compared differences in composition, community diversity, and richness of gut microbiota among children with obesity and high cIMT (OB + high-cIMT), obesity but normal cIMT (OB + non-cIMT), and normal weight and normal cIMT (i.e., normal children) to identify differential microbiota biomarkers.
Methods
A total of 24 OB + high-cIMT children, 24 OB + non-cIMT children, and 24 normal children aged 10–11 years from the Huantai Childhood Cardiovascular Health Cohort Study were included. All included fecal samples were tested using 16S rRNA sequencing. α-diversity analysis was performed to estimate the community richness and diversity of gut microbes, and LEfSe analysis was used to reveal the main differential biomarkers among these three groups. Random forest analysis was used to further select differential biomarkers. The receiver operating characteristic (ROC) curve was used to evaluate the ability of biomarkers in identifying OB + non-cIMT and OB + high-cIMT. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were assessed by Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) according to the KEGG database.
Results
The community richness and diversity of gut microbiota in OB + high-cIMT children were decreased compared with OB + non-cIMT children and normal children. At the genus level, the relative abundances of Christensenellaceae_R-7_group, UBA1819, Family_XIII_AD3011_group, and unclassified_o__Bacteroidales were reduced in OB + high-cIMT children compared with OB + non-cIMT and normal children. In addition, these four significant biomarkers were ranked in the top 1, 2, 6, and 12 in the random forest analysis. ROC analysis results showed that combined Christensenellaceae_R-7_group, UBA1819, Family_XIII_AD3011_group, and unclassified_o__Bacteroidales performed high ability in identifying OB + high-cIMT (area under the curve [AUC]: 0.91, 95% CI = 0.82–1.00]) and moderate ability in identifying OB + non-cIMT (AUC 0.76, 95% CI = 0.62–0.91). PICRUSt showed unique thiamine metabolism and methane metabolism pathways in gut microbial were decreased in OB + high-cIMT compared with OB + non-cIMT.
Conclusion
Gut microbiota plays a pivotal role in detecting children with obesity combined with high cIMT.
Efficacy of ketogenic diet in CDKL5-related epilepsy: a single arm meta-analysis
Authors: Zhang Jie , Ma Jiayi , Chang Xuting , Wu Pengxia , Li Shangru , Wu Ye 
Published: June 2022

Abstract
Background
Drug-resistant epilepsy is one of the most important features of cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder. The ketogenic diet (KD) may be effective for patients with CDKL5-related epilepsy, but there is little high-quality evidence to confirm the efficacy. This meta-analysis investigated the efficacy and safety of KD in CDKL5-related epilepsy.
Methods
The PubMed, Embase, Web of Science, Cochrane Library, WanFang, CNKI and VIP databases were searched for relevant studies published up to January 1, 2022. Two reviewers independently screened the literature according to inclusion and exclusion criteria and evaluated the bias risk of the included studies. Meta-analysis was performed using Review Manager 5.3 software.
Results
A total of 12 retrospective studies involving 193 patients met the inclusion criteria. Meta-analysis revealed that the definite responder rate to KD in the treatment of CDKL5-related epilepsy was 18.0% [95% CI (0.07, 0.67)], with no statistical heterogeneity among studies (I2 = 0%, P = 0.45). The clinical responder rate was 50.5% [95% CI (0.75, 1.39)], and there was no statistical heterogeneity among all studies (I2 = 46%, P = 0.05). Subgroup analysis showed that there was no significant difference in the clinical responder rate between the two groups with seizure onset age before and after 1 month (P = 0.14). Only one study mentioned adverse reactions, and the incidence of adverse reactions was 78.3% (18/23). Constipation and vomiting were the main manifestations, implying a high incidence of gastrointestinal adverse reactions.
Conclusions
The definite responder rate to KD in CDKL5-related epilepsy is 18%, and the gastrointestinal adverse reactions was probably common in these patients. All the studies included in the meta-analysis were retrospective, and most of them had small sample sizes. Additional high-quality studies are needed to confirm the efficacy and tolerance of KD in CDKL5-related epilepsy.
Retrospective comparison of two surgical approaches for incarcerated inguinal hernia: Midline preperitoneal repair and laparoscopic transabdominal preperitoneal (TAPP) surgery
Authors: jiang xiaoming , Sun R.-X. , Huang W.-H. 
Published: June 2022

Abstract
Background：Laparoscopic treatment for incarcerated inguinal hernia has gradually increased, while more surgeons preferred open surgery. Therefore, it is necessary to analyze the safety and effectiveness of the two surgical methods.Methods: The patients with incarcerated/strangulated inguinal hernia treated in Jinshan Hospital (Shanghai, China) from January 2018 to March 2021 were retrospectively analyzed. According to different surgical approaches, the patients were divided into lower abdominal midline incision group (LAMI) and laparoscopic transabdominal preperitoneal (TAPP) group. The characteristics, surgical outcomes and postoperative complications of the two groups were compared retrospectively.Results: 104 incarcerated/strangulated inguinal hernia cases were included in total. The average age was 64.4±16.8 years, 79 of them (76.0%) were male. 44 cases (42.3%) had obvious intestinal obstruction, and a total of 27 cases (26.0%) underwent intestinal resection. There were 62 cases (59.6%) in the LAMI group and 42 cases (40.4%) in the TAPP group. The operation time in the TAPP group was about 15 minutes longer (107.0min versus 92.8min; P =0.012), but postoperative length of hospitalization and time of return to normal activity were shorter in the TAPP group (2.7days versus 6.8days P<0.001 and 8.1 days versus 13.6days; P<0.001). There were 83 cases (79.8%) of 1st stage tension-free herniorrhaphy, including 37 cases (88.1%) in the TAPP group and 46 cases (74.2%) in the LAMI group (P=0.083). The surgical complications such as incision infection (4.8% versus 0 P=0.396), seroma/hematomas (11.3% versus 9.5%, P=1.000), intra-abdominal infection (16.1% versus 2.4% P=0.056), and recurrence (1.6% versus 0 P=1.000) were similar in the two groups. There were no cases of patch infection and chronic pain in the two groups. A total of 2 cases (1.9%) died of multiple organ dysfunction in the LAMI group and no death in the TAPP group.Conclusions: Lower abdominal midline incision approach and TAPP were safe and effective in the treatment of incarcerated inguinal hernia. TAPP showed more favorable short-term results for cases that were easy to retract without intestinal resection. Midline preperitoneal repair was more suitable for strangulated hernia requiring intestinal resection.