bluuebunny/crossref_metadata_2025_split huggingface dataset:
Femtosecond infrared optical vortex lasers based on optical parametric amplification
Authors: Feng Renyu , Qian Junyu , Peng Yujie , Li Yanyan , Li Wenkai , Leng Yuxin , Li Ruxin 
Published: August 2022

Abstract
Infrared femtosecond optical vortices open up many new research fields, such as optical micro–nano manipulation, time-resolved nonlocal spectroscopy in solids, vortex secondary radiation and particle generations. In this article, we demonstrate a femtosecond optical vortex laser system based on a two-stage optical parametric amplifier. In our experiment, 1.45 μm vortex signal pulses with energy of 190 μJ and 1.8 μm vortex idler pulses with energy of 158 μJ have been obtained, and the pulse durations are 51 and 48 fs, respectively. Both the energy fluctuations of the signal and idler pulses are less than 0.5% (root mean square), and the spectral fluctuations are less than 1.5% within 1 hour. This type of highly stable femtosecond optical vortex laser has a wide range of applications for vortex strong-field physics.
High laser damage threshold reflective optically addressed liquid crystal light valve based on gallium nitride conductive electrodes
Authors: Xing Zhibo , Fan Wei , Huang Dajie , Cheng He , Du Tongyao 
Published: August 2022

Abstract
In this paper, the feasibility of a high laser damage threshold liquid crystal spatial light modulator based on gallium nitride (GaN) transparent conductive electrodes is proved. The laser-induced damage threshold (LIDT) is measured, and a high LIDT reflective optically addressed liquid crystal light valve (OALCLV) based on GaN is designed and fabricated. The proper work mode of the OALCLV is determined; the OALCLV obtained a maximum reflectivity of about 55% and an on–off ratio of 55:1, and an image response is demonstrated.
Effect of school feeding program on the anthropometric and haemoglobin status of school children in Sidama region, Southern Ethiopia: a prospective study
Authors: Desalegn Tsion A. , Gebremedhin Samson , Stoecker Barbara J. 
Published: August 2022

Abstract
Ethiopia recently scaled up the implementation of a school feeding program (SFP) as a targeted intervention for protecting disadvantaged school children from hunger and food insecurity. However, the contribution of the program to advancing the nutritional status of children has not been adequately explored. We assessed the effect of SFP on the anthropometric and haemoglobin status of school children in Sidama Region, Southern Ethiopia. Our prospective cohort study compared the height-for-age z-score (HAZ), BMI-for-age z-score (BAZ) and haemoglobin concentration of SFP beneficiary (n 240) and non-beneficiary (n 240) children, 10–14 years of age. The children were recruited from 8 SFP implementing and 8 control schools using a multistage sampling procedure and were followed for an academic year. The SFP intervention and control schools were matched one-to-one based on agro ecological features and geographical proximity. Exposure, outcome and pertinent extraneous variables were collected through baseline and end-line surveys. Multilevel difference-in-differences (DID) analysis was used to measure the net effect on the outcomes of interest. In the multivariable DID model adjusted for potential confounders including maternal and paternal literacy, household monthly income, wealth index and household food insecurity, the SFP did not show significant effects on the haemoglobin concentration (β = 0⋅251, 95 % confidence interval (CI): −0⋅238, 0⋅739), BAZ (β = 0⋅121, 95 % CI: −0⋅163, 0⋅405) and HAZ (β = −0⋅291, 95 % CI: −0⋅640, 0⋅588) of children.
Vaccination, conscientious objection and human rights
Authors: Leigh Ian 
Published: August 2022

AbstractThis paper discusses the extent to which conscientious objections to vaccination qualify for protection under the European Convention on Human Rights (ECHR). Drawing on an examination of the nature of conscience and the ethics of vaccine refusal, it argues that a narrow category of reasons for refusal to be vaccinated can be differentiated from more general ‘vaccine hesitancy’. In relation to conscience objections of this kind, it engages in a systematic analysis of the applicability of the ECHR, both in relation to compulsory vaccination, and so-called ‘vaccine passports’. It concludes that states can – and in some situations must – recognise conscientious objections under the ECHR.
Tracheostomy decision-making for children with medical complexity: What supports and resources do caregivers need?
Authors: Nageswaran Savithri , Gower William A. , King Nancy M. P. , Golden Shannon L. 
Published: August 2022

AbstractObjectivesCaregivers of children with medical complexity (CMC) face decisions about life-sustaining interventions, such as tracheostomy. Our objective is to describe the support needs of caregivers of CMC and the resources they use surrounding tracheostomy decision-making (TDM) for their children.MethodsThis qualitative study, conducted between 2013 and 2015, consisted of semi-structured interviews with 56 caregivers of 41 CMC who had tracheostomies, and 5 focus groups of 33 clinicians at a tertiary care children's hospital. Participants were asked about their perspectives on the TDM process. Qualitative data were transcribed, coded, and organized into themes.ResultsCaregivers used five domains of resources surrounding TDM: (1) social network including extended family members, friends, and clergy; (2) healthcare providers including physicians and nurses; (3) other parents of children with tracheostomy; (4) tangible materials such as print materials, videos, tracheostomy tubes, mannequins, and simulation labs; and (5) internet including websites, social media, and online health communities. Caregivers used these resources for (1) decision-making, (2) becoming knowledgeable and skillful about child's diagnosis, tracheostomy, and home care, and (3) emotional and spiritual well-being. Caregivers agreed that they received enough support, but there were gaps. Clinicians were knowledgeable about these resources, discussed social network and internet less often than the other domains, and identified gaps in supporting caregivers.Significance of resultsCaregivers’ need for support and use of resources surrounding tracheostomy placement for CMC extended beyond decision-making, and included becoming knowledgeable and getting emotional/spiritual support. Healthcare providers exploring these resources with caregivers could improve the quality of TDM communication.
Reducing Weather Influences on an 89 GHz Sea Ice Concentration Algorithm in the Arctic Using Retrievals From an Optimal Estimation Method
Authors: Lu Junshen , Scarlat Raul , Heygster Georg , Spreen Gunnar 
Published: August 2022

AbstractSea ice concentration (SIC) derived from 89 GHz data has up to four times finer spatial resolution compared to that from the widely used 19 and 37 GHz data. But it has lower accuracy due to the enhanced weather influences from water vapor, cloud liquid water (CLW), wind, and surface temperature. Here we improve a high‐resolution SIC algorithm, called the ASI algorithm, based on the difference between vertical and horizontal polarization 89 GHz data, by correcting the observed data for these weather influences through a radiative transfer model and geophysical data retrieved by an optimal estimation method. The improved algorithm denoted ASI3, is developed for the Arctic based on the weather‐corrected brightness temperatures and newly identified open water (80 K) and sea ice (14 K) tie‐points. The most important component of this correction is the inclusion of CLW, the largest weather influence contributor. ASI3 results are evaluated over pure surface sites of 0% and 100% SICs under various weather conditions, showing a much lower average standard deviation (1.1%) than ASI (16.2%). ASI3 reduces weather patterns over pack ice resulting in more homogeneous retrievals but biased toward lower values. Comparison to Landsat imagery under clear‐sky conditions shows that ASI3 results in better agreement with the Landsat SIC than ASI. The number of cases where real sea ice is falsely identified as open water is reduced by ASI3 due to its relaxed open‐water mask and wider water/ice dynamic range.
Stress Drop Estimates for Small to Moderate Earthquakes in Tohoku, Japan Considering Rupture Geometry, Speed, and Directivity
Authors: Shimmoto Shota 
Published: August 2022

AbstractThis study develops a spectral ratio method to estimate the earthquake stress drop considering the rupture geometry, speed, and directivity. This spectral ratio method is applied to Mw 3.3–5.9 earthquakes in Fukushima and Ibaraki, Japan. A rectangular source model with a square rupture front and uniform slip distribution is used to fit spectral ratios stacked by station and wave type for multiple empirical Green's functions, and estimate the finite source properties. Comparing the rupture areas obtained by the spectral ratio method with the slip inversion results shows that our results from the spectral ratio method are associated with a localized area of large slip rather than the overall rupture area. Hence, the rupture area obtained from this spectral ratio method is inappropriate to calculate the average static stress drop. This study proposes a procedure to estimate the average stress drop for the entire rupture area and one for the localized area with large slip, using a source model with a single asperity and heterogeneous stress drop distribution. As a result, we obtained average static stress drops of 0.42–40.2 MPa with a median of 3.7 MPa. The local stress drop is 5.7 times larger than the average static stress drop. This study suggests that a compact area compared to the overall rupture area mainly controls the shape of a broadband seismic spectrum. Thus, we should consider the source heterogeneity in addition to the rupture geometry, speed, and directivity when estimating the stress drops from seismic spectra.
Bridging the phenomenological gap between predictive basic-symptoms and attenuated positive symptoms: a cross-sectional network analysis
Authors: Müller Hendrik , Betz Linda T. , Kambeitz Joseph , Falkai Peter , Gaebel Wolfgang , Heinz Andreas , Hellmich Martin , Juckel Georg , Lambert Martin , Meyer-Lindenberg Andreas , Schneider Frank , Wagner Michael , Zink Mathias , Klosterkötter Joachim , Bechdolf Andreas 
Published: August 2022

AbstractAttenuated positive symptoms (APS), transient psychotic-like symptoms (brief, limited intermittent psychotic symptoms, BLIPS), and predictive cognitive-perceptive basic-symptoms (BS) criteria can help identify a help-seeking population of young people at clinical high-risk of a first episode psychosis (CHRp). Phenomenological, there are substantial differences between BS and APS or BLIPS. BS do not feature psychotic content as delusion or hallucinations, and reality testing is preserved. One fundamental problem in the psychopathology of CHRp is to understand how the non-psychotic BS are related to APS. To explore the interrelationship of APS and predictive BS, we fitted a network analysis to a dataset of 231 patients at CHRp, aged 24.4 years (SD = 5.3) with 65% male. Particular emphasis was placed on points of interaction (bridge symptoms) between the two criteria sets. The BS ‘unstable ideas of reference’ and “inability to discriminate between imagination and reality” interacted with attenuated delusional ideation. Perceptual BS were linked to perceptual APS. Albeit central for the network, predictive cognitive basic BS were relatively isolated from APS. Our analysis provides empirical support for existing theoretical accounts that interaction between the distinct phenomenological domains of BS and APS is characterized by impairments in source monitoring and perspective-taking. Identifying bridge symptoms between the symptom domains holds the potential to empirically advance the etiological understanding of psychosis and pave the way for tailored clinical interventions.
Quantum error correction with silicon spin qubits
Authors: Takeda Kenta , Noiri Akito , Nakajima Takashi , Kobayashi Takashi , Tarucha Seigo 
Published: August 2022

AbstractFuture large-scale quantum computers will rely on quantum error correction (QEC) to protect the fragile quantum information during computation1,2. Among the possible candidate platforms for realizing quantum computing devices, the compatibility with mature nanofabrication technologies of silicon-based spin qubits offers promise to overcome the challenges in scaling up device sizes from the prototypes of today to large-scale computers3–5. Recent advances in silicon-based qubits have enabled the implementations of high-quality one-qubit and two-qubit systems6–8. However, the demonstration of QEC, which requires three or more coupled qubits1, and involves a three-qubit gate9–11 or measurement-based feedback, remains an open challenge. Here we demonstrate a three-qubit phase-correcting code in silicon, in which an encoded three-qubit state is protected against any phase-flip error on one of the three qubits. The correction to this encoded state is performed by a three-qubit conditional rotation, which we implement by an efficient single-step resonantly driven iToffoli gate. As expected, the error correction mitigates the errors owing to one-qubit phase-flip, as well as the intrinsic dephasing mainly owing to quasi-static phase noise. These results show successful implementation of QEC and the potential of a silicon-based platform for large-scale quantum computing.
Efficient generation of entangled multiphoton graph states from a single atom
Authors: Thomas Philip , Ruscio Leonardo , Morin Olivier , Rempe Gerhard 
Published: August 2022

AbstractThe central technological appeal of quantum science resides in exploiting quantum effects, such as entanglement, for a variety of applications, including computing, communication and sensing1. The overarching challenge in these fields is to address, control and protect systems of many qubits against decoherence2. Against this backdrop, optical photons, naturally robust and easy to manipulate, represent ideal qubit carriers. However, the most successful technique so far for creating photonic entanglement3is inherently probabilistic and, therefore, subject to severe scalability limitations. Here we report the implementation of a deterministic protocol4–6for the creation of photonic entanglement with a single memory atom in a cavity7. We interleave controlled single-photon emissions with tailored atomic qubit rotations to efficiently grow Greenberger–Horne–Zeilinger (GHZ) states8of up to 14 photons and linear cluster states9of up to 12 photons with a fidelity lower bounded by 76(6)% and 56(4)%, respectively. Thanks to a source-to-detection efficiency of 43.18(7)% per photon, we measure these large states about once every minute, which is orders of magnitude faster than in any previous experiment3,10–13. In the future, this rate could be increased even further, the scheme could be extended to two atoms in a cavity14,15or several sources could be quantum mechanically coupled16, to generate higher-dimensional cluster states17. Overcoming the limitations encountered by probabilistic schemes for photonic entanglement generation, our results may offer a way towards scalable measurement-based quantum computation18,19and communication20,21.
Symmetry as a grouping cue for numerosity perception
Authors: Maldonado Moscoso Paula A. , Anobile Giovanni , Burr David C. , Arrighi Roberto , Castaldi Elisa 
Published: August 2022

AbstractTo estimate the number of objects in an image, each element needs to be segregated as a single unit. Several principles guide the process of element identification, one of the strongest being symmetry. In the current study, we investigated how symmetry affects the ability to rapidly estimate the number of objects (numerosity). Participants judged the numerosity of asymmetric or symmetric arrays of various numerosities. The results show that the numerosity of symmetrical arrays was significantly underestimated at low numerosities, but the effect was greatly reduced at higher numerosities. Adding an additional axis of symmetry (double symmetry) further reduced perceived numerosity. The magnitude of the symmetry-driven underestimation was inversely correlated with autistic personality traits, consistent with previous work associating autistic traits with perceptual grouping. Overall, these results support the idea that perceived numerosity relies on object segmentation and grouping cues, with symmetry playing a key role.
The combined role of obesity and depressive symptoms in the association with ischaemic heart disease and its subtypes
Authors: Liu Shuo , Luo Jia , Zhang Tianhao , Zhang Dongfeng , Zhang Hua 
Published: August 2022

AbstractThis cross-sectional study aimed to explore the combined effects of depression and obesity on ischemic heart disease and its subtypes. Data from the National Health and Nutrition Examination Survey 2007–2018 were used. A total of 29,050 participants aged 20 years or older were included in the analyses. Logistic regression models and restricted cubic spline models were applied to evaluate the associations between depression symptom and ischemic heart disease. There were significant correlations between depressive symptoms and ischemic heart disease [OR and 95% CI 2.44 (1.91, 3.10)] and its subtypes: coronary heart disease [2.32 (1.67, 3.23)], heart attack [2.18 (1.71, 2.78)], and angina [2.72 (1.96, 3.79)].The synergistic effects of depression with obesity (BMI ≥ 30) and central obesity (waist ≥ 102/88 cm for men/women) on ischemic heart disease were estimated and expressed using the relative excess risk due to interaction (RERI) and the attributable proportion due to interaction (AP). The RERI and AP with 95% CIs of depression and central obesity for ischemic heart disease were 1.10 (0.01, 2.19) and 0.35 (0.06, 0.64). When we analysed the other three subtypes of ischemic heart disease, we only found depressive symptoms and central obesity could have a meaningful synergistic effect on heart attack (RERI: 0.84 (− 0.28, 1.96) AP: (0.31 (0.00, 0.69)).
Network phenotypes and their clinical significance in temporal lobe epilepsy using machine learning applications to morphological and functional graph theory metrics
Authors: Garcia-Ramos Camille , Nair Veena , Maganti Rama , Mathis Jedidiah , Conant Lisa L. , Prabhakaran Vivek , Binder Jeffrey R. , Meyerand Beth , Hermann Bruce , Struck Aaron F. 
Published: August 2022

AbstractMachine learning analyses were performed on graph theory (GT) metrics extracted from brain functional and morphological data from temporal lobe epilepsy (TLE) patients in order to identify intrinsic network phenotypes and characterize their clinical significance. Participants were 97 TLE and 36 healthy controls from the Epilepsy Connectome Project. Each imaging modality (i.e., Resting-state functional Magnetic Resonance Imaging (RS-fMRI), and structural MRI) rendered 2 clusters: one comparable to controls and one deviating from controls. Participants were minimally overlapping across the identified clusters, suggesting that an abnormal functional GT phenotype did not necessarily mean an abnormal morphological GT phenotype for the same subject. Morphological clusters were associated with a significant difference in the estimated lifetime number of generalized tonic–clonic seizures and functional cluster membership was associated with age. Furthermore, controls exhibited significant correlations between functional GT metrics and cognition, while for TLE participants morphological GT metrics were linked to cognition, suggesting a dissociation between higher cognitive abilities and GT-derived network measures. Overall, these findings demonstrate the existence of clinically meaningful minimally overlapping phenotypes of morphological and functional GT networks. Functional network properties may underlie variance in cognition in healthy brains, but in the pathological state of epilepsy the cognitive limits might be primarily related to structural cerebral network properties.
Detection of Leptomonas seymouri narna-like virus in serum samples of visceral leishmaniasis patients and its possible role in disease pathogenesis
Authors: Sukla Soumi , Nath Himadri , Kamran Mohd. , Ejazi Sarfaraz Ahmad , Ali Nahid , Das Pradeep , Ravichandiran V. , Roy Syamal , Biswas Subhajit 
Published: August 2022

AbstractKala-azar/Visceral Leishmaniasis (VL) caused by Leishmania donovani (LD) is often associated with Leptomonas seymouri (LS) co-infection in India. Leptomonas seymouri narna-like virus 1 (Lepsey NLV1) has been reported in multi-passaged laboratory isolates of VL samples which showed LD-LS co-infection. A pertinent question was whether this virus of LS is detectable in direct clinical samples. DNA from the serum of twenty-eight LD diagnosed patients was subjected to LD-specific and LS-specific PCR to reconfirm the presence of LD parasites and to detect LD-LS co-infections. RNA extracted from same samples was subjected to RT-PCR, qRT-PCR and sequencing using virus-specific primers to detect/identify and quantify the virus. The presence of the virus was confirmed in thirteen of eighteen (72%) recently collected VL and PKDL samples. Cytokine profiling showed significantly elevated IL-18 in only LD infected patients compared to the virus-positive LD and control samples. IL-18 is crucial for Th1 and macrophage activation which eventually clears the parasite. The Lepsey NLV1 interaction with the immune system results in reduced IL-18 which favors LD survival and increased parasitic burden. The study emphasizes the need to revisit LD pathogenesis in the light of the association and persistence of a protozoan virus in kala-azar and PKDL patients.
Effect of amide protoporphyrin derivatives on immune response in Apis mellifera
Authors: Trytek Mariusz , Buczek Katarzyna , Zdybicka-Barabas Agnieszka , Wojda Iwona , Borsuk Grzegorz , Cytryńska Małgorzata , Lipke Agnieszka , Gryko Dorota 
Published: August 2022

AbstractThe intracellular microsporidian parasite Nosema ceranae is known to compromise bee health by induction of energetic stress and downregulation of the immune system. Porphyrins are candidate therapeutic agents for controlling Nosema infection without adverse effects on honeybees. In the present work, the impact of two protoporphyrin IX derivatives, i.e. PP[Asp]2 and PP[Lys]2, on Apis mellifera humoral immune response has been investigated in laboratory conditions in non-infected and N. ceranae-infected honeybees. Fluorescence spectroscopy analysis of hemolymph showed for the first time that porphyrin molecules penetrate into the hemocoel of honeybees. Phenoloxidase (PO) activity and the expression of genes encoding antimicrobial peptides (AMPs: abaecin, defensin, and hymenoptaecin) were assessed. Porphyrins significantly increased the phenoloxidase activity in healthy honeybees but did not increase the expression of AMP genes. Compared with the control bees, the hemolymph of non-infected bees treated with porphyrins had an 11.3- and 6.1-fold higher level of PO activity after the 24- and 48-h porphyrin administration, respectively. Notably, there was a significant inverse correlation between the PO activity and the AMP gene expression level (r =  − 0.61696, p = 0.0143). The PO activity profile in the infected bees was completely opposite to that in the healthy bees (r =  − 0.5118, p = 0.000), which was related to the changing load of N. ceranae spores in the porphyrin treated-bees. On day 12 post-infection, the spore loads in the infected porphyrin-fed individuals significantly decreased by 74%, compared with the control bees. Our findings show involvement of the honeybee immune system in the porphyrin-based control of Nosema infection. This allows the infected bees to improve their lifespan considerably by choosing an optimal PO activity/AMP expression variant to cope with the varying level of N. ceranae infection.