bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Tofu Dregs Compost and NPK Fertilizer the Growth and Production of Purple Eggplan (Solanum melongena L.)
Authors: Yulia Arnis EN , Khoiri M. Amrul , Yoseva Sri , Nuraida Nuraida 
Published: May 2022

The research was aimed to see the effect interaction of giving tofu dregs compost and npk fertilizer to get the right dose towards growth and the highest production of purple eggplant. The research was conducted at Experimental Garden, Faculty of Agriculture, Riau University, Pekanbaru. The research was conducted for 5 months, from february to june 2020. The reasearch was conducted experimentally in 2 factors. The first factor was the of tofu waste compost consists of 3 levels (0, 10 and 20 ton.ha-1). The second factor was the of NPK fertilizer (0, 100 and 150 kg.ha-1) which consist of nine treatments combination. The observed parameterswere the height of the plant (cm), the days of flowering (days), the days of harvesting (days), the fruit length (cm), the fruit diameter (cm), the number of fruits per plant (fruit), the fruit weight per fruit (g), the fruit weight per plant (g) and the fruit weight with plot (g). The data in this research was analyzed in using variance and followed by Duncan's multiple distance test at 5% level. The results showed that tofu waste compost and NPK fertilizer increased the growth of eggplant such as the height of the plant, the days of flowering, the days of harvesting, the number of fruits per plant, the fruit length, the fruit weight per fruit, the fruit weight per plant and the fruit weight with plot and does not increase fruit diameter. The giving tofu waste compost at a dose 20 ton.ha-1 and NPK fertilizer 150 kg.ha-1 gave the best eggplant growth and production until the plants were 90 DAP
Condition of Mangrove Forest in the Village of Apar Pariaman Utara District Pariaman City West Sumatra Province
Authors: Alpian Alpian , Efriyeldi Efriyeldi , Thamrin Thamrin 
Published: May 2022

Pariaman Utara District has the most extensive mangrove forest, which is 16.5 ha, in Apar Village the amount (6.0 ha). The purpose of this study was to determine the type and density of mangrove forests and to determine the condition of mangrove forests by determining the percentage of canopy cover in Apar Village. The method used in this research is a survey method, where the data collected is data obtained directly from the field which is then analyzed the data. The research procedure consisted of several stages, namely, collecting density data at 3 stations. Each station consisted of 3 straight line transects along 50 meters from the sea and estuary to land with a position perpendicular to the coast and having a distance between transect lines of 50 meters. In each transect line there are 3 plots arranged in a zigzag manner with a size of 10 m x 10 m for the tree category mangrove community structure. Retrieval of canopy cover photo data which was then analyzed by hemispherical photography. The results of measurements of water quality from the research location were temperature 29 - 30 ° C, salinity 4 - 5 ‰ and pH of the waters were 6-7. The composition of mangroves in the research locations were Sonneratia caseolaris, Sonneratia alba, Rhizophora mucronata, Nypa fructicans. Density at station I, 1700.00 trees/ha, station II 1311.11 trees/ha and station III 1888.89 trees/ha. Canopy cover at station I, 80.65%, station II, 58.46% and station III, 83.21%.
Taxonomic status of intraspecific germplasm resources of Vaccinium uliginosum based on chloroplast matK gene and SRAP molecular markers
Authors: Chen Jia-Zhuo , Li Tong , Tian Xin , Zheng Yu-Hang , Jin Zhen-Ling , Cao Hou-Nan , Zong Cheng-Wen 
Published: May 2022

BACKGROUND: Abundant germplasm resources of Vaccinium uliginosum are present in Changbai Mountain in China, which have considerable research and development value. They include the naturally distributed alpine V. uliginosum, the white-fruited V. uliginosum variety, and various fruit shapes dominated by ellipses. However, the relevant research is limited, and the taxonomic status of various specific germplasm resources has not been addressed. OBJECTIVE: The genetic relationship and taxonomic status of four species of V. uliginosum germplasm resources in Changbai Mountain were investigated. METHODS: The chloroplast matK gene and SRAP molecular markers of 94 V. uliginosum samples were analyzed. RESULTS: According to the analysis of chloroplast matK gene, all four types were divided into three branches. The results showed low variation among natural samples of V. uliginosum in China and a relationship between haplotype distribution and geographical distribution. The results of the SRAP molecular marker analysis divided the V. uliginosum population into five branches. The multiple individuals of the same trait were clustered together, and different partial samples were clustered together. CONCLUSIONS: Diploid alpine V. uliginosum and tetraploid V. uliginosum were identified as two subspecies of V. uliginosum. The elliptical fruit shapewas the variant of tetraploid round blue fruit V. uliginosum, and the white-fruited V. uliginosum variety is a variant.
Lateralized readiness potentials can identify hemisphere of recovery in stroke patients
Authors: El nahas Nevine , Roushdy Tamer M. , Shokri Hossam M. , Moustafa Ramez R. , Elsayed Ahmed M. , Amin Randa M. , Ashour Aya A. , Abd Eldayem Eman H. , Elhawary Ghada A. , Elbokl Ahmed M. 
Published: May 2022

Highlights • In healthy adults, the lateralized readiness potential (LRP) is localized to the hemisphere contralateral to a moving limb. • In stroke, the LRP can lateralize contra-, or ipsilateral to the paretic limb depending on the stage of recovery. • Identification of hemisphere of recovery can guide further measures for enhancing brain plasticity. Background: Event related cortical potentials related to motor action are referred to as movement related cortical potentials. The late component of which is the readiness potential (RP) and its polarity is more negative in the hemisphere responsible for planning of motor action. This lateralized nature of RP during unilateral hand movement is studied as lateralized readiness potential (LRP) by calculating the contralateral-minus-ipsilateral difference wave for each hand. Objective: The aim was to identify the hemisphere contributing to motor recovery in acute and chronic stroke patients through recording LRPs. Methods: Twenty-nine cases with cerebrovascular stroke (15 acute and 14 chronic) were included in the study. EEG was recorded in response to self-cued button presses by the paretic side to obtain the averaged LRP amplitude. The hemisphere with greater negativity was considered the side of recovery. Functional recovery was assessed by Fugl Meyer test. Results: In acute cases, recovery was more related to LRP activity in the contralesional hemisphere (73%), whereas lateralization was equal in chronic cases; 50% in either group. LRP amplitude was higher in the contralesional hemisphere ( p = 0.02). Functional recovery assessed by the Fugl Meyer test (FM) was similar whether recovery was ipsi- or contralesional. Conclusions: Early after stroke, motor recovery is more likely to involve compensatory activity in the contralesional hemisphere, while in the chronic phase, the ipsilesional hemisphere may recover its function and become more active. Further research is needed to verify if the technique mentioned in our study could be used to guide customized NIBS protocols tailoring the optimal site and parameters for each patient.
ПЕРЕДІСТОРІЯ ВИНИКНЕННЯ ЖАНРУ РОМАНУ
Authors: Андріяшик Оксана , Стовпник Наталія 
Published: May 2022

У статті здійснено спробу простежити витоки жанру роману. Важливим поняттям, яке дає змогу здійснити екскурс у найдавніші зразки жанру є «романне слово». У ході дослідження узагальнено теоретичні набутки з проблеми романного слова зокрема і теорії роману загалом. Вдалося прослідкувати певні етапи становлення цього жанру. Також здійснена спроба проаналізувати теорії роману, які враховують концептуальні підходи до вивчення проблеми. Врахована концепція М. Бахтіна, яка полягає в тому, що романне слово з’явилось задовго до того, як роман викристалізувався в окремий жанр. Романне начало у творах ранньої української літератури простежено у літописах, проповідях, ходіннях. У складі цих давніх жанрів, як вдалося з’ясувати, зароджуються передновели як зародки великої епічної форми, коли реальна подія переноситься у сферу художньої оповіді.
Lycorine Inhibits Hypertrophic Scar Formation by Inducing ROS-Mediated Apoptosis
Authors: Dong Yunxian , Lv Dongming , Zhao Zirui , Xu Zhongye , Hu Zhicheng , Tang Bing 
Published: May 2022

Background: Hypertrophic scar (HS) is a fibrotic cutaneous disease with few effective therapies. Lycorine is a drug with pro-apoptotic ability and anti-fibrosis potential. This study aimed to test whether lycorine could trigger the apoptosis of hypertrophic scar fibroblasts (HSFs) to inhibit HS formation.Methods: The proapoptotic and anti-fibrosis effects of lycorine on the viability and apoptosis of human primary HSFs and their reactive oxygen species (ROS) production as well as a rabbit ear model of HS were determined by CCK-8, flow cytometry, Western blot, immunofluorescence, transwell migration, collagen gel contraction assays.Results: Lycorine treatment selectively decreased the viability of HSFs, and induced their apoptosis, but not normal fibroblasts (NFs). Lycorine treatment increased the relative levels of Bax and cleaved PARP expression, cytochrome C cytoplasm translocation, but decreased Bcl-2, caspase-3 and caspase-9 expression, the mitochondrial membrane potential (MMP) in HSFs. Lycorine inhibited the migration and contraction of HSFs, and reduced the expression of collagen I, collagen III and α-SMA. Mechanistically, lycorine treatment stimulated high levels of ROS production, leading to apoptosis of HSFs while treatment with NAC, a ROS inhibitor, significantly mitigated or abrogated the pro-apoptotic and antifibrotic activity of lycorine in HSFs. Moreover, lycorine treatment mitigated the severity of HS in rabbit ears by inducing fibroblast apoptosis.Conclusion: These results indicate that lycorine has a potent anti-fibrotic activity and is a potential drug for intervention of HS.
A Flood Forecasting Framework Coupling a High Resolution WRF Ensemble With an Urban Hydrologic Model
Authors: Davis Saimy , Pentakota Likhitha , Saptarishy Nikita , Mujumdar Pradeep. P. 
Published: May 2022

Numerical weather prediction (NWP) models such as the Weather Research and Forecasting (WRF) model are increasingly used over the Indian region to forecast extreme rainfall events. However, studies which explore the application of high-resolution rainfall simulations obtained from the WRF model in urban hydrology are limited. In this paper, the utility of a model coupling framework to predict urban floods is explored through the case study of Bangalore city in India. This framework is used to simulate multiple extreme events that occurred over the city for the monsoons of years 2020 and 2021. To address the uncertainty from the WRF model, a 12-member convection permitting ensemble is used. Model configurations using Kain Fritsch and WSM6 parameterization schemes could simulate the spatial and temporal pattern of the selected event. The city is easily flooded with rainfall events above a threshold of 60 mm/day and to capture the response of the urban catchment, the Personal Computer Storm Water Management Model (PCSWMM) is used in this study. Flood forecasts are created using the outputs from the WRF ensemble and the Global Forecasting System (GFS). The high temporal and spatial resolution of the rainfall forecasts (&lt;4 km at 15-min intervals), has proved critical in reproducing the urban flood event. The flood forecasts created using the WRF ensemble indicate that flooding and water levels are comparable to the observed whereas the GFS underestimates these to a large extent. Thus, the coupled WRF–PCSWMM modelling framework is found effective in forecasting flood events over an Indian city.
The Nonlinear Correlation Between a Novel Metabolic Score for Insulin Resistance and Subclinical Myocardial Injury in the General Population
Authors: Wang Zhenwei , Li Wei , Li Jingjie , Liu Naifeng 
Published: May 2022

BackgroundGrowing studies have shown that insulin resistance (IR) is associated with cardiovascular disease (CVD), while the association between IR and subclinical myocardial injury (SC-MI) remains unclear. Hence we aimed to assess the association between IR and SC-MI.MethodsIn this cross-sectional study, we enrolled 6043 individuals (age: 58.43 ± 13.08 years; 46.2% men) free from CVD from the third National Health and Nutrition Examination Survey. A novel metabolic score for insulin resistance (METS-IR) was used as alternative markers of IR. Multivariate logistic regression and restricted cubic spline were performed to evaluate the associations between METS-IR and SC-MI.ResultsThe multivariate logistic regression analysis showed that after adjusting for cardiovascular metabolic risk factors, higher METS-IR was independently correlated with higher risk of SC-MI [as a quartile variable, Q4 vs Q1, OR (95% CI): 1.395 (1.147, 1.698), P = 0.001, P for trend &lt; 0.001; as a continuous variable, per 10-unit increment, OR (95% CI): 1.869 (1.524, 2.292), P &lt; 0.001]. Restricted cubic spline indicated that there was a J-curve connection between METS-IR and SC-MI. Threshold effect analysis ascertained an inflection point of 37 of METS-IR. The ORs (95% CIs) of per 10-unit increase of METS-IR for SC-MI were 0.707 (0.538, 0.928) and 1.327 (1.210, 1.456) on the left and right sides of the inflection point (P &lt; 0.05), respectively. Subgroup analysis showed that the association between METS-IR and SC-MI was only statistically significant in participants without diabetes.ConclusionsMETS-IR was nonlinearly related to SC-MI in the general population without CVD.
Pursuing Public Health Benefit Within National Genomic Initiatives: Learning From Different Policies
Authors: Onstwedder Suzanne M. , Jansen Marleen E. , Leonardo Alves Teresa , Cornel Martina C. , Rigter Tessel 
Published: May 2022

Introduction: Population-based genomic research is expected to deliver substantial public health benefits. National genomics initiatives are widespread, with large-scale collection and research of human genomic data. To date, little is known about the actual public health benefit that is yielded from such initiatives. In this study, we explore how public health benefit is being pursued in a selection of national genomics initiatives.Methods: A mixed-method study was carried out, consisting of a literature-based comparison of 11 purposively sampled national genomics initiatives (Belgium, Denmark, Estonia, Finland, Germany, Iceland, Qatar, Saudi Arabia, Taiwan, United Kingdom (UK), and United States (USA)), and five semi-structured interviews with experts (Denmark, Estonia, Finland, UK, USA). It was analyzed to what extent and how public health benefit was pursued and then operationalized in each phase of an adapted public health policy cycle: agenda setting, governance, (research) strategy towards health benefit, implementation, evaluation.Results: Public health benefit within national genomics initiatives was pursued in all initiatives and also operationalized in all phases of the public health policy cycle. The inclusion of public health benefit in genomics initiatives seemed dependent on the outcomes of agenda setting, such as the aims and values, as well as design of governance, for example involved actors and funding. Some initiatives focus on a research-based strategy to contribute to public health, while others focus on research translation into healthcare, or a combination of both. Evaluation of public health benefits could be performed qualitatively, such as assessing improved public trust, and/or quantitatively, e.g. research output or number of new diagnoses. However, the created health benefit for the general public, both short- and long-term, appears to be difficult to determine.Conclusion: Genomics initiatives hold the potential to deliver health promises of population-based genomics. Yet, universal tools to measure public health benefit and clarity in roles and responsibilities of collaborating stakeholders are lacking. Advancements in both aspects will help to facilitate and achieve the expected impact of genomics initiatives and enable effective research translation, implementation, and ultimately improved public health.
Distinct Immunological Profiles Help in the Maintenance of Salivary Secretory IgA Production in Mild Symptoms COVID-19 Patients
Authors: Santos Juliana de Melo Batista dos , Amaral Jonatas Bussador do , França Carolina Nunes , Monteiro Fernanda Rodrigues , Alvares-Saraiva Anuska Marcelino , Kalil Sandra , Durigon Edison Luiz , Oliveira Danielle Bruna Leal , Rodrigues Silvia Sanches , Heller Debora , Welter Eliane Aparecida Rosseto , Pinho João Renato Rebello , Vieira Rodolfo P. , Bachi André Luis Lacerda 
Published: May 2022

BackgroundRelevant aspects regarding the SARS-CoV-2 pathogenesis and the systemic immune response to this infection have been reported. However, the mucosal immune response of the upper airways two months after SARS-CoV-2 infection in patients with mild/moderate symptoms is still not completely described. Therefore, we investigated the immune/inflammatory responses of the mucosa of the upper airways of mild/moderate symptom COVID-19 patients two months after the SARS-CoV-2 infection in comparison to a control group composed of non-COVID-19 healthy individuals.MethodsA cohort of 80 volunteers (age 37.2 ± 8.2), including non-COVID-19 healthy individuals (n=24) and COVID-19 patients (n=56) who presented mild/moderate symptoms during a COVID-19 outbreak in Brazil in November and December of 2020. Saliva samples were obtained two months after the COVID-19 diagnosis to assess the levels of SIgA by ELISA and the cytokines by multiplex analysis.ResultsSalivary levels of SIgA were detected in 39 volunteers into the COVID-19 group and, unexpectedly, in 14 volunteers in the control group. Based on this observation, we distributed the volunteers of the control group into without SIgA or with SIgA sub-groups, and COVID-19 group into without SIgA or with SIgA sub-groups. Individuals with SIgA showed higher levels of IL-10, IL-17A, IFN-γ, IL-12p70, IL-13, and IFN-α than those without SIgA. In intergroup analysis, the COVID-19 groups showed higher salivary levels of IL-10, IL-13, IL-17A, and IFN-α than the control group. No statistical differences were verified in the salivary levels of IL-6 and IFN-β. Lower IL-12p70/IL-10 and IFN-γ/IL-10 ratios were found in the control group without SIgA than the control group with SIgA and the COVID-19 group with SIgA.ConclusionWe were able to present, for the first time, that associations between distinct immunological profiles can help the mucosal immunity to maintain the salivary levels of SIgA in COVID-19 patients two months after the SARS-CoV-2 infection.
Single-Center Experience With Protocolized Treatment of Left Ventricular Assist Device Infections
Authors: Verkaik Nelianne J. , Yalcin Yunus C. , Bax Hannelore I. , Constantinescu Alina A. , Brugts Jasper J. , Manintveld Olivier C. , Birim Ozcan , Croughs Peter D. , Bogers Ad J. J. C. , Caliskan Kadir 
Published: May 2022

PurposeBecause of the current lack of evidence-based antimicrobial treatment guidelines, Left Ventricular Assist Device (LVAD) infections are often treated according to local insights. Here, we propose a flowchart for protocolized treatment, in order to improve outcome.MethodsThe flowchart was composed based on literature, consensus and expert opinion statements. It includes choice, dosage and duration of antibiotics, and indications for suppressive therapy, with particular focus on Staphylococcus aureus (SA) (Figure 1). The preliminary treatment results of 28 patients (2 from start cephalexin suppressive therapy) after implementation in July 2018 are described.ResultsCumulative incidence for first episode of infection in a 3-year time period was 27% (26 of 96 patients with an LVAD). Twenty-one of 23 (91%) first episodes of driveline infection (10 superficial and 13 deep; nine of 13 caused by SA) were successfully treated with antibiotics according to flowchart with complete resolution of clinical signs and symptoms. For two patients with deep driveline infections, surgery was needed in addition. There were no relapses of deep driveline infections, and only 2 SA deep driveline re-infections after 6 months. Nine patients received cephalexin of whom four patients (44%) developed a breakthrough infection with cephalexin-resistant gram-negative bacteria.ConclusionsThe first results of this protocolized treatment approach of LVAD infections are promising. Yet, initiation of cephalexin suppressive therapy should be carefully considered given the occurrence of infections with resistant micro-organisms. The long-term outcome of this approach needs to be established in a larger number of patients, preferably in a multi-center setting.
Efficacy of Microneedling Combined With Local Application of Human Umbilical Cord-Derived Mesenchymal Stem Cells Conditioned Media in Skin Brightness and Rejuvenation: A Randomized Controlled Split-Face Study
Authors: Liang Xuelei , Li Jiaying , Yan Yan , Xu Yongsheng , Wang Xiujuan , Wu Haixuan , Liu Yi , Li Linfeng , Zhuo Fenglin 
Published: May 2022

BackgroundFighting skin aging signs is one of the major challenges of the 21st century, recently, mesenchymal stem cells (MSCs) and microneedling (MN) have been applied for anti-aging. This study aims to evaluate the efficacy of the combination of MN and human umbilical cord-derived mesenchymal stem cells conditioned media (hUC-MSCs-CM) in skin brightness and rejuvenation.MethodsThirty volunteers with facial skin aging were recruited for the randomized, controlled split-face study. The left and right sides of the face were randomly applied with saline via MN or hUC-MSCs-CM via MN. Five sessions were performed for each volunteer at 2-week intervals. Two dermatologists evaluated the clinical improvement, in terms of skin brightness and texture. A satisfaction score based on a self-evaluation questionnaire was recorded at 2 weeks after the last treatment. The objective evaluation was recorded before the first treatment, and at 2 weeks after the last treatment.ResultsTwenty-eight volunteers with a mean (SD) age of 41 (6.54) years old completed the trial. The investigator’s assessment for skin brightness and texture, and the self-satisfaction score revealed statistically better effects in hUC-MSCs-CM -plus-MN group than in MN alone (MN saline) group. No severe side effects were reported during the whole study period. Compared to MN alone group, the objective assessment revealed significant improvements in skin brightness (reduced melanin index, ultraviolet spots, and brown spots) and skin texture (reduced wrinkles and pores, and increased skin elasticity) in hUC-MSCs-CM-plus-MN group, while there were no obvious differences in skin hydration, trans-epidermal water loss, and the erythema index.ConclusionThe combination of hUC-MSCs-CM and MN exhibite anti-aging efficacy, and this could be used for facial rejuvenation in the future.