bluuebunny/crossref_metadata_2025_split huggingface dataset:
The importance of children and young person involvement in scoping the need for a paediatric glucocorticoid-associated patient reported outcome measure
Authors: Singhal S. , Smith E. M. D. , Roper L. , Pain C. E. 
Published: October 2022

Abstract
Background
For many children and young people (CYP) with paediatric rheumatic conditions, glucocorticoid medications and their associated side-effects have a substantial impact on disease experience. Whilst there are physician-rated measures of glucocorticoid toxicity, no parallel patient reported measure has been developed to date for CYP with rheumatic disease. This manuscript describes a series of public patient involvement (PPI) events to inform the development of a future paediatric glucocorticoid-associated patient reported outcome measure (PROM).

Methods
One large group PPI event was advertised to CYP with experience of glucocorticoid medication use and their parents through clinicians, charities and existing PPI groups. This featured education on the team’s research into glucocorticoid medication and interactive polls/structured discussion to help participants share their experiences. Further engagement was sought for PPI group work to co-develop future glucocorticoid studies, including development of a glucocorticoid associated PROM. Quantitative and qualitative feedback was collected from online questionnaires. The initiative was held virtually due to the Covid-19 pandemic.

Results
Nine families (n = 15) including 6 CYP joined the large group PPI event. Online pre-attendance and post-attendance questionnaires showed improvement in mean self-reported confidence [1 = not at all confident, 5 = very confident] in the following: what steroid medications are (pre = 3.9, post = 4.8), steroid side effects (pre = 3.8, post = 4.6), patient-reported outcome measures (pre = 2.0, post = 4.5), available research on steroids (pre = 2.2, post = 3.5). Five families (n = 7) were involved in a monthly PPI group who worked alongside the research team to identify priorities in glucocorticoid research, produce age-appropriate study materials, identify barriers to study participation (e.g. accessibility & convenience) and recommend appropriate modalities for dissemination. The participants found discussing shared experiences and learning about research to be the most enjoyable aspects of the initiative.

Conclusions
This PPI initiative provided a valuable forum for families, including young children, to share their perspectives. Here, the authors explore the effective use of PPI in a virtual setting and provide a unique case study for the involvement of CYP in PROM development. The monthly PPI group also identified a need for the development of a new PROM related to glucocorticoid medication use and provided unique insights into how such a study could be structured.
Demographic and risk factors profile of intracranial atherosclerotic stenosis in the Kingdom of Bahrain
Authors: Al-Nidawi Firas , Mohamed Mohamed Wael , Hussein Ali , Alataibi Noora , Althahabi Rawan , Almaawi Ahmed , Qassim Aya , Das Priya 
Published: October 2022

Abstract
Background
Intracranial atherosclerotic stenosis (ICAS) is one of the most common causes of stroke worldwide. This study aimed to analyze the demographic and risk factor profiles of ICAS in the Kingdom of Bahrain. The study population included 477 patients who were hospitalized in the Neurology Department from March 1, 2018, to September 1, 2020 because of acute ischemic stroke and underwent arterial brain imaging (CTA or MRA) examination during their hospitalization.

Results
Of 477 patients, 123 (25.7%) had ICAS. A history of stroke/transient ischemic attack was significantly higher in patients with intracranial stenosis (P = 0.012). Patients with ICAS had significant concurrent extracranial arterial stenosis (ECAS) (P = 0.00). In Bahraini patients, dyslipidemia was associated with a higher percentage of developing ICAS, but this was statistically nonsignificant (p = 0.06).

Conclusions
An independent and significant correlation was found between ICAS and stroke recurrence. In addition, a concurrent existence of ECAS and ICAS was noted.
Mechanisms involved in the anticancer effects of sinapic acid
Authors: Pandi Anandakumar , Kalappan Vanitha Manickam 
Published: October 2022

Abstract
Background
Cancer refers to a group of diseases characterized by the development of abnormal cells that divide uncontrollably and have the ability to infiltrate and destroy normal body tissue. Worldwide, it is the second most leading cause of death. Dietary intake of bioactive compounds from plant sources has been documented for their protective effect against different types of human ailments including cancer.

Main body
Sinapic acid (3,5-dimethoxy-4-hydroxycinnamic acid) (SA) is a promising phytochemical, available in oil seeds, berries, spices, vegetables and cereals. SA has been well documented for its antibacterial, anti-peroxidative, anti-hyperglycemic, anticancer, hepatoprotective, reno-protective, anti-inflammatory, neuroprotective, immunomodulatory and anticancer effects. Nevertheless, the anticancer activity of SA has remained a challenge with regard to understanding its mechanism in health and diseases.

Short conclusion
This review is an effort to summarize the updated literature available about the mechanisms involved in the anticancer effects of SA in order to recommend this compound for further future investigations.
Assessment of auditory function in hepatitis “C” patients managed by combination of sofosbuvir and daclatsavir
Authors: Meghezel El-Zahraa M. , Abd Al-Ghaffar Mohammed A. , Mohammad Asmaa Naser , Mahmoud Samar M. , Abdelaal Usama M. , Mourad Salwa 
Published: October 2022

Abstract
Background
To evaluate the effect of daclatasvir and sofosbuvir on auditory function in hepatitis C patients. Thirty hepatitis C virus (HCV) patients were included in this study with age ranged from 22 to 55 years. All patients underwent full audiological evaluation before beginning and after completion of their treatment with combination of daclatasvir and sofosbuvir.

Result
When the results of audiological data were compared before and after treatment, we found that; there were statistically significant differences in the pure tone audiometry (PTA) threshold and ART bilaterally mainly in the high frequency region. Transient evoked otoacoustic emission (TEOAE) reproducibility showed a statistically significant difference bilateral. However, there was no statistically significant difference in the Auditory Brainstem Response (ABR) findings.

Conclusion and recommendations
The combination therapy of daclatasvir and sofosbuvir used in patients with HCV led to deterioration in the hearing threshold in the basic audiological tests (PTA and immitancemetry). In addition, it had an adverse effect on the cochlear OHCs, with no affection on auditory nerve, brain stem functions or in sub-thalamic function, it seems that it had no effect, we cannot confirm. The study evaluate hearing at the end of treatment immediately. We recommend performing a routine monitoring of auditory functions in HCV patients treated with daclatasvir and sofosbuvir combination by specialist for early detection of auditory changes to avoid further damage to auditory system.
Effect of platelet-rich plasma combined with tranexamic acid in the treatment of melasma and its effect on the serum levels of vascular endothelial growth factor, endothelin-1 and melatonin
Authors: Zhang Ci , Wu Tianpeng , Shen Nan 
Published: October 2022

Objective: To investigate the effect of platelet-rich plasma (PRP) combined with tranexamic acid (TXA) in the treatment of melasma and its effect on the serum levels of vascular endothelial growth factor (VEGF), endothelin-1 (ET-1) and melanin stimulating hormone (MSH).
Methods: We retrospectively analyzed clinical data of 80 patients with melasma treated in our hospital from January 2020 to June 2021. Patients (n=38) in the control group received simple oral TXA treatment. Patients (n=42) in the study group received PRP combined with oral TXA treatment. We assessed the treatment effects on the serum biochemical index levels, the adverse reactions, and the recurrence rates in the two groups.
Results: The total efficacy of the study group (90.48%) was higher than that of the control group (73.68%) (p<0.05). After the treatment, the levels of serum VEGF increased and the levels of ET-1 and MSH decreased in both groups, but the changes in the study group were more pronounced than those in the control group (p<0.05). We found similar incidences of the adverse reaction in the study group (7.14%) and the control group (5.26%; p>0.05). The disease recurrence rates between the two groups three months after the treatment were similar (p>0.05). However, the disease recurrence rate in the study group (4.76%) was lower than that in the control group (21.05%) 6 months after treatment (p<0.05).
Conclusions: PRP combined with oral TXA can improve the treatment effect of TXA alone in the treatment of melasma, maintaining normal levels of VEGF, ET-1 and MSH, reducing disease recurrences.
doi: https://doi.org/10.12669/pjms.38.8.6786
How to cite this:Zhang C, Wu T, Shen N. Effect of platelet-rich plasma combined with tranexamic acid in the treatment of melasma and its effect on the serum levels of vascular endothelial growth factor, endothelin-1 and melatonin. Pak J Med Sci. 2022;38(8):2163-2168. doi: https://doi.org/10.12669/pjms.38.8.6786
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Recent research progress and advanced applications of silica/polymer nanocomposites
Authors: Li Hongwei , Cheng Bingxu , Gao Weichen , Feng Chunni , Huang Chongxing , Liu Yang , Lu Peng , Zhao Hui 
Published: October 2022

Abstract
Silica (SiO2) is one of the most promising inorganic nanofillers, and it has been widely used in the preparation of polymer nanocomposites due to its adjustable morphology, large specific surface area, and ease of functionalization. The surface modification, structural characteristics, and bonding mechanisms of SiO2 are crucial in enhancing the overall performance of polymer nanocomposites. This review focuses on summarizing the recent progress made regarding the preparation and structure characterization methods, unique properties, and rheological behavior of SiO2/polymer nanocomposites. In addition, the latest applications of SiO2/polymer nanocomposites in coatings, smart devices, biomedicine, and environment are further explored. A comprehensive summary of the main challenges, opportunities, and perspectives regarding SiO2/polymer nanocomposites is also presented.
Comparison of Barricor tube and serum separator tube in outpatients
Authors: Orhan Bagnu , Mercan Hilal , Deniz Levent , Erdogan Zeynep , Bercik Inal Berrin 
Published: October 2022

Abstract

Objectives
In clinical laboratories, it is common to obtain serum and plasma by using a barrier tube due to its various advantages. In this study, we aimed to compare 18 biochemistry analytes in outpatient clinic and outpatient oncology patients by measuring in a Barricor tube and a serum separator tube (SST).

Methods
Venous blood was drawn into the Barricor tube and SST from volunteers consisting of outpatients and outpatient oncology patients. The biochemical parameters were measured using the AU2700 autoanalyser (Beckman Coulter Inc., CA, USA) and Beckman Coulter Access immunoanalyser (Beckman Coulter Inc., CA, USA). The biochemical analytes evaluated in the two participant groups were compared between the Barricor tube and SST.

Results
In the study, when the results in both the outpatient group and the outpatient oncology patient group, bias (%), allowable bias (%), CV (%), allowable CV (%), total error (%), total allowable error (TEa) (%) were evaluated; potassium (K) total error (%) between Barricor tube and SST exceeded TEa, however, all other parameters were within TEa.

Conclusions
Considering its various advantages and compared biochemical analytes, we think that can be switched to the Barricor tube in clinical laboratories and the reference range change can be made for K.
The Transient Performance-Evaluation Model for Desalination of Seawater Based on Matrix Algorithm – a Requirement for a Ported Arabic Smart City
Authors: Liu Jingrui , Pan Dongyang 
Published: October 2022

Abstract
Based on the transient performance model for desalination of seawater based on the matrix algorithm, the desalination device is designed according to the evaporation condensation mechanism of falling film in horizontal tube, and its structure operation and operation principle are analyzed. Then, the differential equation of the transient heat-conduction problem of the seawater desalination device is constructed. On the basis of experimental data or numerical calculation results, the temperature field of structure at some time is selected to form the snapshots matrix, and a set of optimal eigenorthogonal decomposition bases is obtained by eigenorthogonal decomposition of the snapshots matrix. Finally, the finite-element discrete scheme of the nonlinear transient heat-conduction problem is reduced by using eigenorthogonal decomposition bases of the linear problem, and the lower-order ordinary differential equations of the reduced-order model for the nonlinear transient heat-conduction problem of the seawater desalination device are obtained. The ordinary differential equations of the reduced-order model are solved by solving the ordinary differential equations of the reduced-order model. The distribution of the temperature field at each time of the structure is obtained. The performance of the model is verified by numerical examples under the conditions of two-stage temperature-difference heating and only the top-level heating. The results show that the model has good accuracy and efficiency.
Looking for Justice in the Black Cloud: Providing Justice for Victims of Sexual Harassment in Indonesia
Authors: Hamdalah Mutiara 
Published: October 2022

According to Komnas Perempuan, sexual harassment is a sexual act through physical or non-physical touch that targets the sexual organs or sexuality of the victim. This includes using whistles, flirting, sexually suggestive speech, displaying pornographic material and sexual desires, touching or touching body parts, gestures or gestures of a sexual nature that cause discomfort, be offended, feel humiliated, and possibly cause health problems. and safety. The law also has its own interpretation of sexual harassment. In the Criminal Code (KUHP) there is no term sexual harassment, but in Article 289 to Article 296 of the Criminal Code it is called obscenity. R. Soesilo in the book “KUHP and its comments”, sexual harassment includes acts that violate a sense of decency, or other vile acts, and all of them are in an environment of sexual lust. For example, kissing, groping the genitals, groping the breasts and so on. The term sexual harassment, according to Ratna, refers to sexual harassment which is defined as unwelcome attention or legally defined as an imposition of unwelcome sexual demands or creation of sexually offensive environments.
Book Review “Negeri Para Bedebah”, Tere Liye, PT Gramedia Pustaka Utama, Jakarta, ISBN: 9789792285529
Authors: Kadir La Ode Ibrah Haikal Rachman 
Published: October 2022

This novel has a political economy theme. In accordance with the theme, this novel raises a lot about economic and political issues. The setting of the place used in this novel is mostly in Jakarta. Apart from being in Jakarta, Thomas also spends a lot of time on his Pacific Cruise Ship. This is where after escaping for the umpteenth time, Thomas took his entourage to the Pacific ship which was at the yatch dock in the Thousand Islands area to simply avoid the police who wanted to arrest them. A very interesting novel for lovers of Tere Liye's novels to follow. The story in this novel is a work of fiction that is no less exciting than the real story that is happening in this country, this novel tells the story of Thomas as a true fighter who never betrays what he has said.
Tranexamic Acid Should be Considered for High Risk Arthroplasty Patients
Authors: Ho Andy , Campbell David , Yapa Shanil , Malek Ibrahim , Yates Pier 
Published: October 2022

Background
Tranexamic acid significantly reduces blood loss and transfusion requirements in arthroplasty patients. However, it is often avoided in patients who have had previous arterial and thromboembolic disease despite the absence of evidence of hazard in this group of patients. We examined the use of tranexamic acid in unselected hip and knee arthroplasty patients including those considered to be ‘high risk’.

Methods
A 2-year retrospective multicentre study was performed with patients who underwent hip or knee arthroplasty surgery. A blood management protocol included universal tranexamic acid use for all patients. Blood loss, transfusion volumes and complications were analysed.

Results
A total of 958 patients were included in the study, 130 patients were considered ‘high risk’ of thromboembolic complications and 828 patients were considered ‘low risk’. 879 patients received tranexamic acid with a significant reduction in blood loss (p<0.001) in these patients.
Two of 130 (1.5%) ‘high risk’ patients and 14 of 828 (1.7%) ‘low risk’ patients had post-operative VTE. There was no significant difference in rate of VTE between the ‘high risk’ and ‘low risk’ patients (p=0.6) or in the subgroup of ‘high risk’ patients who had received TXA (p=1).

Conclusions
The efficacy of tranexamic acid is overwhelming and outweighs any potential risks. Tranexamic acid should be considered for use in all arthroplasty patients including those with prior history of venous or arterial thrombosis.
First-year English majors' reading habits, reading skills and strategies from EFL and English literature tutors' perspective: An interview study
Authors: Pereszlényi Anna 
Published: October 2022

AbstractPreparing English as a foreign language (EFL) students for final exams and language exams has become more and more significant in secondary education. However, those students who continue their studies as English majors have to live up to new expectations and rise to different challenges such as reading and discussing literary texts written in English. Thus, they would need help, nevertheless it is generally believed in many university courses that students have already reached the needed language proficiency level and they are able to read academic texts in English without having difficulties (Paran, 2008). Therefore, first-year English majors are often unprepared to cope with the demands made on them in literature courses. The main objective of this interview study, involving four EFL and four English literature tutors from a university in Hungary, is to explore the tutors' perceptions on first-year English majors' reading habits, what reading skills and strategies are required in literature courses. The findings provide an insight into some of the issues related to reading texts in English, what demands English majors have to meet when they enter tertiary education, and some possible solutions.
Focus on 10th grade students with learning problems: What influences their achievements?
Authors: Hegedűs Roland , Sebestyén Krisztina 
Published: October 2022

AbstractThere is an increased interest in exploring the interaction between knowledge of foreign languages, Reading and Mathematics and correlation of students' achievement in Hungary (e. g. Szirmai, 2003; Garami, 2009; Hegedűs & Sebestyén, 2019). Special learner groups are rarely put in the focus of research, therefore in our paper, we examine achievements in Reading and Mathematics of students with learning disorder or integration, learning and behavioural difficulties (ILBD). We examine data in different types of classes, for example, in special classes with a high number of foreign language lessons. We analyse the data of National Competency Measurement (NCM) of 2019 in the 10th grade (N = 83,751) with SPSS. In this database, there are 3,029 students with learning disorder and 4,284 students with ILBD. 5.9% of the first group and 9% of the latter group learn in classes with a high number of foreign language lessons per week. According to our results, these students have better competence results from Reading and Mathematics than students who learn in classes with “normal” curriculum, and lower achievements than students in classes with a special curriculum.
Молодежь и строительство нации
Authors: Ильинский Игорь Михайлович 
Published: October 2022

<p>В своей статье известный социальный философ, ректор Московского гуманитарного университета И. М. Ильинский обсуждает проблему образования и воспитания молодежи в контексте строительства новой российской нации. Согласно точке зрения автора, корни проблем, с которыми столкнулось сегодняшнее российское общество — в перестройке и последующих реформах 1990-х гг. В этот период произошла деградация системы образования, как и всех остальных сфер жизни российского общества. В статье обсуждается целый ряд проблем — образования, воспитания, формирования человеческого потенциала, взаимодействия России с Западом, демографическая ситуация. Автор высоко оценивает роль нынешнего президента РФ В. В. Путина в укреплении российского общества и государства. Выход из кризисной ситуации, который предлагается в статье, заключается в проведении сильной молодежной политики, направленной на формирование активного, самостоятельного, образованного, патриотически настроенного человека, способного понимать смысл происходящего. </p>
Трансформация модели социально-экономического развития России от профессоров «Национального центра» в историческом контексте
Authors: Макаревич Эдуард Федорович 
Published: October 2022

<p>В статье анализируются модели социально-экономического развития России на ключевых поворотах истории страны: профессоров «Национального центра» — организации, разработавшей программу политического и экономического возрождения страны после ожидаемого взятия Москвы добровольческой армией генерала А.В. Деникина; В. И. Ленина как автора новой экономической политики; академика Сахарова, развивавшего концепцию конвергенции; Дэн Сяопина, творца китайского экономического чуда. В ходе этого анализа выделяется то диалектическое общее и то оригинальное, что присутствовало в этих моделях и имеет отношение к настоящему, к определению целей и выработке принципов и методов социально-экономического развития страны. Таким образом, складывается интегральная модель развития, которая включает конвергенцию социалистической и капиталистической экономических систем; взаимодействие и кооперацию государственной и частной форм собственности, государственный капитализм на основе сочетания плана и рынка, конкурентной борьбы на рынке продуктов социалистического и частного производства при контролирующей роли власти. Именно такую интегральную модель применил Китай, используя опыт реализации новой экономической политики Ленина и идею конвергенции в редакции академика Сахарова. В этой интегральной модели социализм сдерживает алчность и железную хватку капитализма, а капитализм укрощает бюрократию и контролирующую функцию социализма. </p>