bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building a Culture of Health Through the Built Environment: Impact of a Cluster Randomized Trial Remediating Vacant and Abandoned Property on Health Mindsets
Authors: Theall Katherine P. , Wallace Jasmine , Tucker Amber , Wu Kimberly , Walker Brigham , Gustat Jeanette , Kondo Michelle , Morrison Christopher , Pealer Casius , Branas Charles C. , Richardson Lisa 
Published: February 2025

Abstract
Changing built environment conditions to impact health mindsets and health equity may be a promising target for public health interventions. The present study was a cluster randomized controlled trial to test the impact of remediating vacant and abandoned properties on factors related to health mindset—including well-being, health interconnectedness, social capital markers, neighborhood disorder, and worry—as well as direct and indirect violence experiences and the moderating role of racial and income segregation on outcomes. A residential cohort of 405 participants from 194 randomly assigned geographic clusters was surveyed over five waves from 2019 to 2023. Compared to clusters with no treatment, participants in clusters where both vacant lots and abandoned homes were treated experienced significant increases in sense of community (83%, 95% CI = 71 to 96%, p = 0.01). Among participants in randomization clusters where only vacant lots were treated, there were declines in perceived neighborhood disorder (− 55%, 95% CI = − 79 to − 5, p = 0.06) and worry about community violence (− 56%, 95% CI = − 58 to − 12, p = 0.06). There was also a moderating effect of racial and income spatial polarization, with the greatest changes in sense of community observed among more deprived areas with both homes and lots treated, and the largest changes in neighborhood worry and disorder were seen in more deprived areas with only lots treated. Remediation of vacant and abandoned properties may be one approach to change some but not all mindsets around health, and the effects may depend on the type of remediation as well as larger neighborhood conditions such as segregation.
SOX10-Mediated Regulation of Enteric Glial Phenotype in vitro and its Relevance for Neuroinflammatory Disorders
Authors: Kunke Madlen , Kaehler Meike , Boni Sebastien , Schröder Katja , Weier Alicia , Chunder Rittika , Kuerten Stefanie , Böttner Martina , Cascorbi Ingolf , Neunlist Michel , Wedel Thilo , Lucius Ralph , Cossais François 
Published: February 2025

Abstract
The transcription factor SOX10 is a key regulator of myelinated glial cell phenotype and function, with a known role in multiple sclerosis (MS). SOX10 is also expressed in enteric glial cells (EGC) within the gut, yet its regulatory functions in EGC remain poorly understood. This study aimed to identify SOX10 target genes that influence EGC phenotype and may have implications for MS. An EGC cell line was established for doxycycline-inducible SOX10 overexpression. Impact of SOX10 overexpression on EGC phenotype was assessed by genome-wide expression analysis and results were validated via RT-qPCR and western blot. Data were compared with SOX10 ChIP-seq and transcriptomic datasets from MS patients to identify pan-glial SOX10 target genes potentially linked to neuroinflammatory disorders. SOX10 overexpression was associated with ectopic upregulation of genes related to myelin regulation and glial differentiation, as evidenced by increased PLP1 expression at mRNA and protein levels. Comparison to ChIP-seq and MS datasets highlight SOX10 target genes, including PLP1, RNF130, NES and APOD potentially involved in central and peripheral manifestations of MS pathology. Our findings support a cell-specific regulation of EGC phenotype through SOX10 expression level and identify SOX10-regulated genes relevant to EGC function. This research advances the understanding of EGC diversity and provide information about glial cells targeting in neuroinflammatory disorders.
Cation Channel TMEM63A Autonomously Facilitates Oligodendrocyte Differentiation at an Early Stage
Authors: Wang Yue-Ying , Wu Dan , Zhan Yongkun , Li Fei , Zang Yan-Yu , Teng Xiao-Yu , Zhang Linlin , Duan Gui-Fang , Wang He , Xu Rong , Chen Guiquan , Xu Yun , Yang Jian-Jun , Yu Yongguo , Shi Yun Stone 
Published: February 2025

Abstract
Accurate timing of myelination is crucial for the proper functioning of the central nervous system. Here, we identified a de novo heterozygous mutation in TMEM63A (c.1894G>A; p. Ala632Thr) in a 7-year-old boy exhibiting hypomyelination. A Ca2+ influx assay suggested that this is a loss-of-function mutation. To explore how TMEM63A deficiency causes hypomyelination, we generated Tmem63a knockout mice. Genetic deletion of TMEM63A resulted in hypomyelination at postnatal day 14 (P14) arising from impaired differentiation of oligodendrocyte precursor cells (OPCs). Notably, the myelin dysplasia was transient, returning to normal levels by P28. Primary cultures of Tmem63a
−/− OPCs presented delayed differentiation. Lentivirus-based expression of TMEM63A but not TMEM63A_A632T rescued the differentiation of Tmem63a
−/− OPCs in vitro and myelination in Tmem63a
−/− mice. These data thus support the conclusion that the mutation in TMEM63A is the pathogenesis of the hypomyelination in the patient. Our study further demonstrated that TMEM63A-mediated Ca2+ influx plays critical roles in the early development of myelin and oligodendrocyte differentiation.
Corynebacterium glutamicum: Modellorganismus der bakteriellen Zellbiologie
Authors: Bramkamp Marc 
Published: February 2025

Abstract

Corynebacterium glutamicum is used in biotechnology for the industrial-scale production of amino acids, particularly glutamate and lysine. Beyond its role in production, Corynebacterium glutamicum has become a new model organism for microbial cell biology in recent years. Its well-characterized genetics, robust metabolism, and non-pathogenicity allow exploration of bacterial cell processes, such as cell wall synthesis, division, and response to environmental stress, positioning it as a new model for studying fundamental biological mechanisms in prokaryotes.
Signaling to survive: linear ubiquitination in health and disease
Authors: Celik Gulustan , Weinelt Nadine , van Wijk Sjoerd J. L. 
Published: February 2025

Abstract
Post-translational modification with ubiquitin (Ub) controls protein stability, localization and function and occurs as single entity, or as poly-Ub chains, linked via lysine residues or the N-terminal methionine (M1 poly-Ub). Generated by the linear ubiquitin chain assembly complex (LUBAC) and counteracted by the deubiquitinating enzymes OTULIN and CYLD, M1 poly-Ub controls immune signaling, survival and cell death. Here, we discuss old and new functions of M1 poly-Ub in health and disease.
Medical plastic waste recyclability potential analysis for the implementation of circular economy: Adama Hospital Medical College, Ethiopia
Authors: Siraj Keredin Temam , Feyie Endale Kebede , Debalke Abbay Gebretsadik , Mergiya Aschalew Tadesse , Eblenkamp Markus , Jodeit Fabian , Mela Petra 
Published: February 2025

Abstract
This study aimed to identify the sources, types, and volumes of medical plastic waste generated at Adama Hospital Medical College and to evaluate its recyclability potential during the 2022–2023 period. Accordingly, 19 plastic items were identified, categorized into 6 classes based on their application and contamination. Mass of identified product was multiplied by the number of the consumed product to determine total consumption. Annual plastic product consumption was calculated for each product and analyzed in terms of polymer composition of the plastic products. Accordingly, 38 tons of medical plastic products were consumed directly from hospital stock while 9.5 tons of plastic medical supplies were brought into the hospital by patients annually. Personal protective equipment ranked first and accounted for 52% of the total medical plastic consumption, followed by IV infusion sets (26%), syringes (15.5%), and tubing’s (4.6%). Composition assessment revealed that, latex ranked first (49.8%) and followed by polyvinyl chloride (30.1%) and polypropylene (16.3%). At the time of the study, the hospital had based on 200 active beds with 92.9% occupancy rate and waste generation rate of 1.23 kg/bed/day. The recyclability potential analysis revealed that IV solution bags ranked first followed by disposable syringes, oxygen masks and nasal oxygen catheters as products with the highest potential and overall representing 31.2% of the medical products consumed in the hospital. Proper source segregation, development of a recycling infrastructure, raising the awareness of hospital staff should be considered in order to increase the recycling potential of medical plastic wastes.
Design and characterization of a magnetorheological elastomer linear actuator for low-frequency applications
Authors: Bellelli Alberto , Vairo Antonio , Spaggiari Andrea 
Published: February 2025

Abstract
This work presents the design and characterization of an innovative linear actuator for low-frequency applications based on a magnetorheological elastomer (MRE) disc coupled to an electromagnet. MREs are a class of smart materials in which micrometre-sized magnetic particles are suspended in an elastomeric matrix. Most research works study their applicability as semi-active systems, but less effort is devoted to their applicability in actuators, but their applicability in the field is possible and could lead to potential advantages in terms of integration of the system especially for microactuation. The proposed MRE device relies on a commercial electromagnet which provides linear motion of the MRE element. The stiffness of the elastomeric matrix is exploited to bring the system back to its initial position, so that the system is monostable. The magneto-mechanical behaviour is modelled both analytically and by means of finite element magneto-mechanical simulations, and the models are compared with the experimental tests. Two membrane thicknesses and two different gaps between the membrane and the electromagnetic actuator were manufactured and characterized. The results show the effect of the design variable on the actuator behaviour and confirm that the analytical model provided can predict the actuator’s behaviour with a good approximation in all the configuration analysed. The dynamic range of the proposed system, regardless of the configuration selected, demonstrates that the magnetic contribution is always able to increase the actuator force by 50% and that the provided model can easily be used as a reliable design tool for this kind of smart system.
A Flexible-Integrated Multimodal Hydrogel-Based Sensing Patch
Authors: Wang Peng , Wang Guoqing , Sun Guifen , Bao Chenchen , Li Yang , Meng Chuizhou , Yao Zhao 
Published: February 2025

Abstract
Sleep monitoring is an important part of health management because sleep quality is crucial for restoration of human health. However, current commercial products of polysomnography are cumbersome with connecting wires and state-of-the-art flexible sensors are still interferential for being attached to the body. Herein, we develop a flexible-integrated multimodal sensing patch based on hydrogel and its application in unconstraint sleep monitoring. The patch comprises a bottom hydrogel-based dual-mode pressure–temperature sensing layer and a top electrospun nanofiber-based non-contact detection layer as one integrated device. The hydrogel as core substrate exhibits strong toughness and water retention, and the multimodal sensing of temperature, pressure, and non-contact proximity is realized based on different sensing mechanisms with no crosstalk interference. The multimodal sensing function is verified in a simulated real-world scenario by a robotic hand grasping objects to validate its practicability. Multiple multimodal sensing patches integrated on different locations of a pillow are assembled for intelligent sleep monitoring. Versatile human–pillow interaction information as well as their evolution over time are acquired and analyzed by a one-dimensional convolutional neural network. Track of head movement and recognition of bad patterns that may lead to poor sleep are achieved, which provides a promising approach for sleep monitoring.
Digital twins for intelligent cities: the case study of Matera
Authors: De Benedictis Riccardo , Cesta Amedeo , Pellegrini Riccardo , Diez Matteo , Pinto Diego Maria , Ventura Paolo , Stecca Giuseppe , Felici Giovanni , Scalas Andreas , Mortara Michela , Cabiddu Daniela , Pittaluga Simone , Spagnuolo Michela , Silvestri Stefano , Damiano Emanuele , Sicuranza Mario , Ciampi Mario , Tognola Gabriella , Strambini Lucanos , Malvezzi Roberto , Presta Ida G. , Camardelli Marialucia , Castelli Giordana , Campana Emilio Fortunato 
Published: February 2025

Abstract
The digital twin (DT) paradigm provides a purpose-built digital representation of a physical system. DTs are often composed by several interconnected models, which need to be specifically tailored to fit the DT purposes. The objective of this work is the development of an urban digital twin (UDT) for the city of Matera, following urban intelligence (UI) paradigm. The latter leverages the multi-disciplinary integration and optimization of the city systems and subsystems to develop purpose-driven DTs and support the decision-making process. The UDT is intended to support governance, stakeholders, and citizens, integrating morphological data for the city representation, reliable simulation tools and data-driven methods for the city state prediction (e.g., traffic, solar irradiation), optimization algorithms for planning and emergency response, sensors for vehicle and pedestrian traffic volumes and environmental monitoring (e.g., pollutant distributions), and a participatory data collection process from the citizens. A Data Lake is used to make available to the UDT modules the data produced by the morphological representation, simulations/data-driven methods, sensors, and the participatory data. The Data Lake provides a standardized approach for the aggregation and extraction of information. Finally, an Urban Sensing Engine supports the decision-making process with artificial intelligence forms of reasoning, to effectively combine the information produced by the UDT components.
Advancement on the small-scale fabrication of pure copper parts via material extrusion AM: process performance and quality mapping
Authors: Parenti Paolo , Gavazzoni Matteo , Foletti Stefano , Colosimo Bianca Maria 
Published: February 2025

Abstract
The potential of copper 3D printing is being explored in a growing number of applications, many of which involve small geometric products and intricate features. Concerning the pure copper AM printability using material extrusion (MEX) (also known as metal extrusion), it stands out as one of the most promising technologies due to the effective coupling of simple 3D printing by extrusion and the subsequent debinding and sintering processes. Despite its user-friendly nature and cost-effectiveness, this method presents limitations especially when dealing with small specimens and features, where geometrical properties and mechanical strength have not been fully explored in the literature. This study investigates the capabilities of piston-fed MEX technology when millimetric parts/features have to be produced in pure copper. The findings indicate that high-dimensional accuracy can be achieved, providing static material resistance in tensile testing that mirrors that of larger parts. In this scale size, the geometric deviations occur at all stages of the design process—from STL to slicing program, on the green and sintered parts—underscoring the importance of managing error propagation. The roles of process parameters, such as layer height and extrusion speed, are outlined and linked to process outcomes. While their impact is significant on dimensional accuracy, surface quality and final porosity, their influence on the produced parts’ microstructure and static mechanical properties proves limited, highlighting the robustness of this production technique and facilitating the optimal parameters selection.
The clinical and demographic profile of inpatient psychosis admissions in Ireland
Authors: Lovett Harriet Alexandra , Lynn Ena , Daly Antoinette , Corcoran Ciaran , O’Connor Karen 
Published: February 2025

Abstract

Objectives:
To examine the clinical and demographic profile of inpatient psychosis admissions in Ireland.

Methods:
Anonymised data was extracted from the Health Research Board (HRB) National Psychiatric Inpatient Reporting System (NPIRS) from 2013–2022. The NPIRS database is maintained by the HRB and records all admissions to inpatient units and hospitals on the register of approved centres under the Mental Health Act 2001. Data was reviewed and analysed using SPSS V26.

Results:
There were 43,963 psychosis admissions over the 10-year period corresponding to 26% of all psychiatric admissions. Males accounted for 58% of psychosis admissions. The median age at first admission was 36 years of age for males and 42 years of age for females. Median length of stay in days was longer for psychosis admissions (median = 20 days IQR = 8–43) than for other mental health disorders (median = 13 days IQR = 4.0–33).

Conclusions:
Understanding the clinical and demographic profile of psychosis related inpatient psychiatric admissions in Ireland provides insights that can inform effective service planning and care delivery. The findings of this study have particular relevance for the implementation and evolution of the Health Service Executive Early Intervention in Psychosis Clinical Programme.
Crowded Out: The Influence of Mental Load Priming on Intentions to Participate in Public Life
Authors: Helgøy Anna , Weeks Ana Catalano 
Published: February 2025

Abstract
How does cognitive household labour – the ‘mental load’ involved in anticipating, fulfilling, and monitoring household needs – influence decisions about whether and how to participate in public life? Studies suggest women take on the vast majority of this load, yet the impact of these private sector inequalities on participation in public life is underexplored. To make progress on these questions, we contribute new causal evidence about the effect of prompting respondents to think about their own mental loads in a survey experiment fielded to employed British parents. Our main argument is that priming the mental load will crowd out interest in political and labour market participation. In line with expectations, our survey experiment finds a strong negative effect of mental load priming on intentions to engage in politics and at work. Our results offer new insights about the continuing relevance of household-based inequalities to gender equality in public life.
Using local ecological knowledge to identify land-use threats to the last wild population of the Chinese alligator Alligator sinensis
Authors: Lau Erika Y. X. , Hodge Josh A. , Rio Jonathan P. , Pan Tao , Mannion Philip D. , Turvey Samuel T. 
Published: February 2025

Abstract
Conservation management in human-modified landscapes requires information on the sustainability of interactions between people and biodiversity. Wild Chinese alligators Alligator sinensis only persist within the National Chinese Alligator Reserve in south-eastern China, where they live alongside agricultural communities that utilize local terrestrial and wetland habitats. We conducted an interview survey of communities within and around the Reserve to evaluate whether local ecological knowledge can provide a baseline on the species' local status and trends, and to understand the relationships between land-use practices and alligator presence and survival. Respondents within the Reserve were more likely to recognize alligators, report sightings and perceive declines than other respondents. Absolute levels of knowledge and experience of alligators were low, highlighting the species' perilous status, and analysis of correlative patterns between respondents' experiences and associated data on human–environmental interactions provides new conservation-relevant insights. Alligator sightings were more likely to be reported by respondents who did not grow crops, and eggs and nests by those who did not utilize local water sources for irrigation, suggesting that existing environmental pressures associated with agriculture may be unsustainable for alligators. Although respondents who lived outside the Reserve were more likely to use agrochemicals, we found no relationship between pesticide or fertilizer usage and variation in respondent awareness or experience of alligators. Our findings indicate that China's last wild alligators continue to experience negative human pressures, and current land-use practices are probably incompatible with long-term alligator survival.
Consequences of a Global Slowdown in Seafloor Spreading for Sea Level and Mantle Heat Loss
Authors: Dalton Colleen A. , Huber Christian , Herbert Timothy D. , Si Weimin 
Published: February 2025

AbstractVariations in global mean sea level over millions of years originate from changes in both the climate and solid Earth systems. Most previous studies of the solid Earth contribution to sea level focused on the past 100 Myr or longer with a temporal resolution of 10 Myr or coarser. Here, we consider how sea level was affected by a 35% global slowdown in ocean crust production that occurred during 15–6 Ma, as was recently identified from marine magnetic anomalies. We calculate how the seafloor area‐age distribution evolves over time in response to the slowdown in crust production, exploring how assumptions about the initial condition and crust destruction rate affect the results. The slowdown decreases the proportion of young shallow seafloor relative to older deeper seafloor, which produces a sea‐level fall of 24–30 m if the plate‐cooling model is used to describe the age dependence of bathymetry and a slightly larger fall if the half‐space cooling model is used. The slowdown also increases the prevalence of slow and ultraslow spreading centers, which, by inhibiting mantle melting, causes the ocean crust to thin by 0.5 km, with a concomitant additional 2‐m sea‐level fall. Although an easily interpretable record of sea‐level variations from sequence stratigraphy does not exist for the past 15 Myr, data from coastal New Jersey and offshore Nova Scotia are broadly consistent with our predictions. If the slowdown affects volcanic degassing, atmospheric CO2, and the climate, thermosteric and ice effects can produce additional sea‐level fall of >60 m.
Iterative Helmholtz Surface Wave Tomography Using Generalized Wave Equation Smoothing Splines—Application to Western Europe
Authors: Sergeant A. , Delage K. , Chevrot S. 
Published: February 2025

AbstractOver the last decade, the expansion and densification of broadband seismic networks has led to an increased interest in tomographic approaches based on gradiometry, which relies on the spatial derivatives of the phase and amplitude of surface wavefronts. Nevertheless, the use of amplitude information remains challenging. In this study, we present a novel approach to Helmholtz tomography based on the use of generalized wave equation smoothing splines. The application of these generalized smoothing splines results in the generation of smooth amplitude and phase fields that satisfy the Helmholtz and transport equations, and hence the wave equation. This enables the direct derivation of phase velocity maps using the Helmholtz equation. We apply this new Helmholtz tomography approach to Rayleigh waves recorded by permanent and temporary networks in Western Europe from 2008 to 2022 to obtain phase velocity maps for periods between 25 and 120 s. These maps reveal the detailed structure of the crust and upper mantle in this region. Compared to eikonal tomography, the phase velocity anomalies obtained by Helmholtz tomography are stronger in amplitude and more sharply defined.