bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atypical Functional Connectivity During Unfamiliar Music Listening in Children With Autism
Authors: Freitas Carina , Hunt Benjamin A. E. , Wong Simeon M. , Ristic Leanne , Fragiadakis Susan , Chow Stephanie , Iaboni Alana , Brian Jessica , Soorya Latha , Chen Joyce L. , Schachar Russell , Dunkley Benjamin T. , Taylor Margot J. , Lerch Jason P. , Anagnostou Evdokia 
Published: April 2022

BackgroundAtypical processing of unfamiliar, but less so familiar, stimuli has been described in Autism Spectrum Disorder (ASD), in particular in relation to face processing. We examined the construct of familiarity in ASD using familiar and unfamiliar songs, to investigate the link between familiarity and autism symptoms, such as repetitive behavior.MethodsForty-eight children, 24 with ASD (21 males, mean age = 9.96 years ± 1.54) and 24 typically developing (TD) controls (21 males, mean age = 10.17 ± 1.90) completed a music familiarity task using individually identified familiar compared to unfamiliar songs, while magnetoencephalography (MEG) was recorded. Each song was presented for 30 s. We used both amplitude envelope correlation (AEC) and the weighted phase lag index (wPLI) to assess functional connectivity between specific regions of interest (ROI) and non-ROI parcels, as well as at the whole brain level, to understand what is preserved and what is impaired in familiar music listening in this population.ResultsIncreased wPLI synchronization for familiar vs. unfamiliar music was found for typically developing children in the gamma frequency. There were no significant differences within the ASD group for this comparison. During the processing of unfamiliar music, we demonstrated left lateralized increased theta and beta band connectivity in children with ASD compared to controls. An interaction effect found greater alpha band connectivity in the TD group compared to ASD to unfamiliar music only, anchored in the left insula.ConclusionOur results revealed atypical processing of unfamiliar songs in children with ASD, consistent with previous studies in other modalities reporting that processing novelty is a challenge for ASD. Relatively typical processing of familiar stimuli may represent a strength and may be of interest to strength-based intervention planning.
The Association Between Hyperuricemia and Obesity Metabolic Phenotypes in Chinese General Population: A Retrospective Analysis
Authors: Feng Xiaojing , Yang Yanyi , Xie Huiqi , Zhuang Siqi , Fang Yiyuan , Dai Yufeng , Jiang Ping , Chen Hongzhi , Tang Haoneng , Tang Lingli 
Published: April 2022

PurposeSerum uric acid (UA) not only affects the development of obesity but also alters the metabolic status in obese subjects; thus we investigated the relationship between serum UA and the overweight/obese metabolic phenotypes.MethodsThe demographic, biochemical, and hematological data were collected for 12,876 patients undergoing routine physical examination, and 6,912 participants were enrolled in our study. Participants were classified into four obesity metabolic phenotypes according to their BMI and the presence of metabolic syndrome: metabolically healthy overweight/obese (MHOO), metabolically healthy and normal weighted (MHNW), metabolically abnormal and overweight/obese (MAOO), and metabolically abnormal but normal weighted (MANW). Univariate and multivariate logistic regression analysis, stratified analysis, and also interaction analysis were conducted to analyze the relationship between serum UA and obesity metabolic phenotypes.ResultsMultivariable logistic regression analysis showed that hyperuricemia was positively associated with MHOO, MANW, and MAOO phenotypes relative to MHNW. After adjusting for the confounding factors, the odds ratios (OR) for individuals with hyperuricemia to be MHOO, MANW, and MAOO phenotypes were 1.86 (1.42–2.45), 2.30 (1.44–3.66), and 3.15 (2.34–4.24), respectively. The ORs for having MHOO, MANW, and MAOO increased 6% [OR: 1.06 (1.05–1.07), P &lt; 0.0001], 5% [OR: 1.05 (1.03–1.07), P &lt; 0.0001], and 11% [OR: 1.11 (1.10–1.13), P &lt; 0.0001] for each 10 unit (μmol/L) of increase in serum UA level. Stratification analysis as well as an interaction test showed that sex and age did not interfere with the association of hyperuricemia with each metabolic phenotype. In terms of the components of the metabolic syndrome, after adjusting for other confounding factors including all of the metabolic indicators except itself, hyperuricemia was positively associated with increased BMI [OR: 1.66 (1.32–2.09), P &lt; 0.0001], hypertriglyceridemia [OR: 1.56 (1.21–2.02), P = 0.0006], and hypertension [OR: 1.22 (1.03–1.46), P = 0.0233], while it had no significant association with hyperglycemia and low HDL-C (all P &gt; 0.05).ConclusionIn our study, we discovered that hyperuricemia was positively associated with MHOO, MANW, and MAOO phenotypes, and this relationship was independent of sex and age.
Predictive Value of Delta-Radiomics Texture Features in 0.35 Tesla Magnetic Resonance Setup Images Acquired During Stereotactic Ablative Radiotherapy of Pancreatic Cancer
Authors: Simpson Garrett , Jin William , Spieler Benjamin , Portelance Lorraine , Mellon Eric , Kwon Deukwoo , Ford John C. , Dogan Nesrin 
Published: April 2022

PurposeThe purpose of this work is to explore delta-radiomics texture features for predicting response using setup images of pancreatic cancer patients treated with magnetic resonance image guided (MRI-guided) stereotactic ablative radiotherapy (SBRT).MethodsThe total biological effective dose (BED) was calculated for 30 patients treated with MRI-guided SBRT that delivered physical doses of 30–60 Gy in three to five fractions. Texture features were then binned into groups based upon BED per fraction by dividing BED by the number of fractions. Delta-radiomics texture features were calculated after delivery of 20 Gy BED (BED20 features) and 40 Gy BED (BED40 features). A random forest (RF) model was constructed using BED20 and then BED40 features to predict binary outcome. During model training, the Gini Index, a measure of a variable’s importance for accurate prediction, was calculated for all features, and the two features that ranked the highest were selected for internal validation. The two features selected from each bin were used in a bootstrapped logistic regression model to predict response and performance quantified using the area under the receiver operating characteristic curve (AUC). This process was an internal validation analysis.ResultsAfter RF model training, the Gini Index was highest for gray-level co-occurrence matrix-based (GLCM) sum average, and neighborhood gray tone difference matrix-based (NGTDM) busyness for BED20 features and gray-level size zone matrix-based (GLSZM) large zones low gray-level emphasis and gray-level run length matrix-based (GLRLM) run percentage was selected from the BED40-based features. The mean AUC obtained using the two BED20 features was AUC = 0.845 with the 2.5 percentile and 97.5 percentile values ranging from 0.794 to 0.856. Internal validation of the BED40 delta-radiomics features resulted in a mean AUC = 0.567 with a 2.5 and 97.5 percentile range of 0.502–0.675.ConclusionEarly changes in treatment quantified with the BED20 delta-radiomics texture features in low field images acquired during MRI-guided SBRT demonstrated better performance in internal validation than features calculated later in treatment. Further analysis of delta-radiomics texture analysis in low field MRI is warranted.
Using New Vaginal Doses Evaluation System to Assess the Dose–Effect Relationship for Vaginal Stenosis After Definitive Radio(Chemo)Therapy for Cervical Cancer
Authors: Wang Juan , Zhang Kai-shuo , Liu Zi , Wang Tao , Wang Rui-hua , Zhang Fu-quan , Yu Lang , Wang Ya-li , Wei Li-chun , Shi Mei , Li Sha , Liu Bao-gang , Shi Fan , Su Jin , Yuan Wei , Zhang Qi ying , Zhang Jing 
Published: April 2022

ObjectiveThe study aims to investigate if a relationship exists between vaginal doses and vaginal stenosis (VS) using posterior–inferior border of symphysis (PIBS) points and the International Commission on Radiation Units-Rectum (ICRU-R) point evaluation system for definitive radio(chemo)therapy in locally advanced cervical cancer.Methods and MaterialsFrom a vaginal dose study in China, 351 patients were prospectively assessed. For every reference point of the PIBS system and ICRU-R point was calculated for all BT and summed with EBRT. Pearson’s chi-square test and Student’s unpaired t-test compared variables with and without vaginal stenosis (VS) G ≥2. The risk factors were assessed for VS G ≥2 in multi- and univariate analyses through Cox proportional hazards model followed by a dose–effect curve construction. The VS morbidity rate was compared via the log-rank test using the median vaginal reference length (VRL).ResultsThe patients (38-month median follow-up) had 21.3% three-year actuarial estimate for VS G ≥2. Compared to G &lt;2 patients, VS G ≥2 patients received higher doses to PIBS points except for PIBS − 2 and had significantly shorter VRL. VRL (HR = 1.765, P = 0.038), total EBRT and BT ICRU-R point dose (HR = 1.017, p = 0.003) were risk factors for VS. With VRL &gt;4.6 cm, the 3-year actuarial estimate was 12.8% vs. 29.6% for VRL ≤4.6 cm. According to the model curve, the risks were 21, 30, and 39% at 75, 85, and 95 Gy, respectively (ICRU-R point dose).ConclusionsPIBS system point doses correlated with late vaginal toxicity. VRL combined with both EBRT and BT dose to the ICRU-R point contribute to VS risk.
Cost-Effectiveness of Bevacizumab Biosimilar LY01008 Combined With Chemotherapy as First-Line Treatment for Chinese Patients With Advanced or Recurrent Nonsquamous Non-Small Cell Lung Cancer
Authors: Luo Xia , Liu Qiao , Zhou Zhen , Yi Lidan , Peng Liubao , Wan Xiaomin , Zeng Xiaohui , Tan Chongqing , Li Sini 
Published: April 2022

Objective: To investigate whether LY01008, a locally developed bevacizumab biosimilar agent, is appropriate for widespread use among Chinese advanced or recurrent nonsquamous non-small cell lung cancer (NSCLC) patients, our current study was designed to evaluate the cost-effectiveness of first-line LY01008 combined with platinum-doublet chemotherapy versus chemotherapy alone from the perspective of the Chinese healthcare system.Material and Methods: This economic evaluation designed a Markov model to compare the healthcare cost and quality-adjusted life-year (QALY) of first-line LY01008 combined with chemotherapy versus first-line chemotherapy. Transition probabilities, including disease progression, survival, and adverse event (AE)-related discontinuation of first-line treatment, were estimated using data from the clinical trials. Costs and health utilities were derived from local databases, hospitals, and published literature. Our base case analysis and scenario analysis focused on the cost-effectiveness of chemotherapy combined with a clinical trial dosage (15 mg/kg every 3-week cycle) and a real-world dosage (7.5 mg/kg every 3-week cycle) of LY01008, respectively.Results: In the base case analysis, first-line LY01008 combined with chemotherapy was associated with an increase of 0.48 QALYs in effectiveness and an increase of CNY 189,988 (US$ 26,240) in healthcare costs compared with first-line chemotherapy, resulting an incremental cost-effectiveness ratio (ICER) of CNY 375,425 (US$ 54,430)/QALY. In the scenario analysis, first-line LY01008 combined with chemotherapy was associated with a mean healthcare cost of CNY 265,060 (US$ 38,429), resulting an ICER of CNY 221,579 (US$ 32,125/QALY) between first-line LY01008 combined with chemotherapy versus first-line chemotherapy. The parameters that determine the cost of LY01008 have the greatest impact on the cost-effectiveness results.Conclusion: From the perspective of the Chinese healthcare system, first-line LY01008 at a real-world dosage combined with chemotherapy is likely to represent a cost-effective strategy compared with first-line chemotherapy alone for Chinese advanced or recurrent nonsquamous NSCLC patients.
High Energetic Demand of Elite Rowing – Implications for Training and Nutrition
Authors: Winkert Kay , Steinacker Juergen M. , Koehler Karsten , Treff Gunnar 
Published: April 2022

Purpose: Elite rowers have large body dimensions, a high metabolic capacity, and they realize high training loads. These factors suggest a high total energy requirement (TER), due to high exercise energy expenditure (EEE) and additional energetic needs. We aimed to study EEE and intensity related substrate utilization (SU) of elite rowers during rowing (EEEROW) and other (EEENON-ROW) training.Methods: We obtained indirect calorimetry data during incremental (N = 174) and ramp test (N = 42) ergometer rowing in 14 elite open-class male rowers (body mass 91.8 kg, 95% CI [87.7, 95.9]). Then we calculated EEEROW and SU within a three-intensity-zone model. To estimate EEENON-ROW, appropriate estimates of metabolic equivalents of task were applied. Based on these data, EEE, SU, and TER were approximated for prototypical high-volume, high-intensity, and tapering training weeks. Data are arithmetic mean and 95% confidence interval (95% CI).Results: EEEROW for zone 1 to 3 ranged from 15.6 kcal·min−1, 95% CI [14.8, 16.3] to 49.8 kcal·min−1, 95% CI [48.1, 51.6], with carbohydrate utilization contributing from 46.4%, 95% CI [42.0, 50.8] to 100.0%, 95% CI [100.0, 100.0]. During a high-volume, a high-intensity, or a taper week, TER was estimated to 6,775 kcal·day−1, 95% CI [6,651, 6,898], 5,772 kcal·day−1, 95% CI [5,644, 5,900], or 4,626 kcal∙day−1, 95% CI [4,481, 4,771], respectively.Conclusion: EEE in elite open-class male rowers is remarkably high already during zone 1 training and carbohydrates are dominantly utilized, indicating relatively high metabolic stress even during low intensity rowing training. In high-volume training weeks, TER is presumably at the upper end of the sustainable total energy expenditure. Periodized nutrition seems warranted for rowers to avoid low energy availability, which might negatively impact performance, training, and health.
Examining Neurosteroid-Analogue Therapy in the Preterm Neonate For Promoting Hippocampal Neurodevelopment
Authors: Shaw Julia C. , Dyson Rebecca M. , Palliser Hannah K. , Sixtus Ryan P. , Barnes Heather , Pavy Carlton L. , Crombie Gabrielle K. , Berry Mary J. , Hirst Jonathan J. 
Published: April 2022

Background: Preterm birth can lead to brain injury and currently there are no targeted therapies to promote postnatal brain development and protect these vulnerable neonates. We have previously shown that the neurosteroid-analogue ganaxolone promotes white matter development and improves behavioural outcomes in male juvenile guinea pigs born preterm. Adverse side effects in this previous study necessitated this current follow-up dosing study, where a focus was placed upon physical wellbeing during the treatment administration and markers of neurodevelopment at the completion of the treatment period.Methods: Time-mated guinea pigs delivered preterm (d62) by induction of labour or spontaneously at term (d69). Preterm pups were randomized to receive no treatment (Prem-CON) or ganaxolone at one of three doses [0.5 mg/kg ganaxolone (low dose; LOW-GNX), 1.0 mg/kg ganaxolone (mid dose; MID-GNX), or 2.5 mg/kg ganaxolone (high dose; HIGH-GNX) in vehicle (45% β-cyclodextrin)] daily until term equivalence age. Physical parameters including weight gain, ponderal index, supplemental feeding, and wellbeing (a score based on respiration, activity, and posture) were recorded throughout the preterm period. At term equivalence, brain tissue was collected, and analysis of hippocampal neurodevelopment was undertaken by immunohistochemistry and RT-PCR.Results: Low and mid dose ganaxolone had some impacts on early weight gain, supplemental feeding, and wellbeing, whereas high dose ganaxolone significantly affected all physical parameters for multiple days during the postnatal period when compared to the preterm control neonates. Deficits in the preterm hippocampus were identified using neurodevelopmental markers including mRNA expression of oligodendrocyte lineage cells (CSPG4, MBP), neuronal growth (INA, VEGFA), and the GABAergic/glutamatergic system (SLC32A1, SLC1A2, GRIN1, GRIN2C, DLG4). These deficits were not affected by ganaxolone at the doses used at the equivalent of normal term.Conclusion: This is the first study to investigate the effects of a range of doses of ganaxolone to improve preterm brain development. We found that of the three doses, only the highest dose of ganaxolone (2.5 mg/kg) impaired key indicators of physical health and wellbeing over extended periods of time. Whilst it may be too early to see improvements in markers of neurodevelopment, further long-term study utilising the lower doses are warranted to assess functional outcomes at ages when preterm birth associated behavioural disorders are observed.
Efficacy of Laparoscopic Surgery Combined With Leuprorelin in the Treatment of Endometriosis Associated With Infertility and Analysis of Influencing Factors for Recurrence
Authors: Yu Lu , Sun Yunming , Fang Qiongyan 
Published: April 2022

ObjectiveTo explore the curative effect of laparoscopic surgery combined with leuprorelin in the treatment of endometriosis with infertility and the related factors of recurrence after treatment.MethodsA total of 158 patients with endometriosis and infertility were selected in our hospital from January 2019 to June 2020. Patients were randomly divided into the control group and the observation group, with 79 patients in each group. Patients in the control group was treated by laparoscopy surgery combined with dydrogesterone, while those in the observation group was treated with laparoscopic surgery combined with leuprorelin. The hormone levels, recurrence rate, pregnancy rate and adverse reaction of the two groups were compared. Combined with clinical and pathological information, the related factors of postoperative recurrence were analyzed.ResultsAfter treatment, the levels of luteinizing hormone, follicle-stimulating hormone and estradiol in the observation group were lower than those in the control group (P &lt; 0.05). The recurrence rate at 12 months after operation in the observation group was lower than that in the control group, and the pregnancy rate was higher than that in the control group (P &lt; 0.05). However, there was no significant difference in the incidence of adverse reactions between the two groups (P &gt; 0.05). Preoperative dysmenorrhea was an independent risk factor for postoperative recurrence in patients with endometriosis, and postoperative pregnancy was a protective factor for postoperative recurrence in patients with endometriosis (P &lt; 0.05).ConclusionLaparoscopy combined with leuprorelin in the treatment of endometriosis with infertility can improve hormone levels, increase the pregnancy rate and reduce the recurrence rate. Preoperative dysmenorrhea is an independent risk factor for postoperative recurrence, which should be quantified and included in the recurrence risk prediction model. Postoperative pregnancy can reduce the recurrence rate after operation, and patients with fertility requirements should be encouraged to make activ preparations for postoperative pregnancy.
A Comparative Analysis of Printed Circuit Boards with Surface-Mounted and Embedded Components under Natural and Forced Convection
Authors: Korobkov Maksim , Vasilyev Fedor , Mozharov Vladimir 
Published: April 2022

This article is dedicated to the research of the physical reliability of electronic devices. It consists of a comparative thermal analysis of the cooling efficiency of a surface-mounted and an embedded component on a printed circuit board. A simulated finite element model of heat distribution over a printed circuit board with a surface component was constructed. An experiment confirmed the objectivity of the modeling results. The component’s temperature was then analyzed depending on the installation method (surface and embedded) and the cooling method (natural and forced with varying airflow velocities). The results showed that the temperature of the embedded component was less than the temperature of the surface-mounted component under natural convection and, in most cases, under forced convection (with an airflow velocity of forced cooling under 16 ms).
Tablets, Sealings and Weights at Ebla: Administrative and Economic Procedures at the beginning of the Archaic State in Syria
Authors: Peyronel Luca 
Published: April 2022

ment and movement of goods is recorded by the use of cylinder seals on sealings and on pottery vessels. In the palace were found around two hundred clay sealings with cylinder-seal impressions and more than fifty storage jars with seal impressions. Cretulae
come from various functional contexts, with significant concentrations only in the northern storerooms and central archive, whilst seal-impressed jars were scattered in various quarters, including the northern warehouse, the units of the Central Quarter devoted to processing foodstuffs, and the ‘ kitchen’ which opened at the bottom of the Ceremonial Staircase. The third category of indicators of administrative management of goods is represented by balance weights, a fundamental tool enabling the palace administration to check and record disbursement and incoming quantities of precious materials and objects. More than forty stone weights were retrieved in the palace, with at least two significant concentrations that permit the localization The extraordinary state of preservation of the Royal Palace G of Ebla (c. 2400-2300 BC) with a large amount of materials sealed by the destruction levels and the presence of central and temporary archives in several rooms of the official wings of the palatial complex allow a detailed analysis of the distribution and types of the various indicators of exchange and the control of exchange. Economic written documents, sealings (cretulae, bullae and jar-sealings) and balance weights attest to the economic activities conducted within the palace and provide integrated information regarding administrative procedures. Together with these indicators, unworked precious materials (in particular lapis lazuli), imported items, and objects manufactured from imported materials show the palace administration’s control over luxury goods production and Ebla’s extended interregional exchange network. In addition to the administrative archives (with thousands of tablets), the manage- of weight sets. The evaluation of the archaeological indicators, based on the distribution and associations of these various categories of object, makes readily identifiable the ‘ places’ appointed to house single or multiple parts of the procedural chain of administrative activity : the final stage in the codification of economic transactions consisted of written cuneiform texts on clay tablets ; the interim level of recording is represented by the cretulae
used to seal goods of various sorts ; and the most crucial steps in recording, when goods enter or leave the palace, are distinguished by various forms of weighing operation.
PENGARUH KOMITMEN, MORAL REASONING, DAN TEKANAN SOSIAL TERHADAP KEPUTUSAN AUDITOR INSPEKTORAT PROVINSI MALUKU UTARA
Authors: Mamulati Irman , Ekaria Ekaria 
Published: April 2022

Tujuan penelitian ini untuk menguji pengaruh komitmen, moral reasoning, serta tekanan sosial terhadap keputusan auditor. Sebanyak 44 orang auditor Inspektorat Provinsi Maluku Utara digunakan sebagai. Teknik pengambilan sampel menggunakan purposive sampling. Regresi linier berganda digunakan dalam teknik analisis data dalam penelitian ini. Adapun komitmen, moral reasoning, dan tekanan sosial sebagai variabel independen, sementara keputusan auditor sebagai variabel dependen. Hasil penelitian menunjukkan bahwa komitmen dan moral reasoning berpengaruh terhadap keputusan auditor. Sedangkan tekanan sosial tidak berpengaruh terhadap keputusan auditor.