bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived barriers to psychiatric help-seeking in South Korea by age groups: text mining analyses of social media big data
Authors: Seo Hwo Yeon , Song Gil Young , Ku Jee Won , Park Hye Yoon , Myung Woojae , Kim Hee Jung , Baek Chang Hyeon , Lee Nami , Sohn Jee Hoon , Yoo Hee Jeong , Park Jee Eun 
Published: May 2022

Abstract
Background
The psychiatric treatment gap is substantial in Korea, implying barriers in seeking help.

Objectives
This study aims to explore barriers of seeing psychiatrists, expressed on the internet by age groups.

Methods
A corpus of data was garnered extensively from internet communities, blogs and social network services from 1 January 2016 to 31 July 2019. Among the texts collected, texts containing words linked to psychiatry were selected. Then the corpus was dismantled into words by using natural language processing. Words linked to barriers to seeking help were identified and classified. Then the words from web communities that we were able to identify the age groups were additionally organized by age groups.

Results
97,730,360 articles were identified and 6,097,369 were included in the analysis. Words implying the barriers were selected and classified into four groups of structural discrimination, public prejudice, low accessibility, and adverse drug effects. Structural discrimination was the greatest barrier occupying 34%, followed by public prejudice (27.8%), adverse drug effects (18.6%), and cost/low accessibility (16.1%). In the analysis by age groups, structural discrimination caused teenagers (51%), job seekers (64%) and mothers with children (43%) the most concern. In contrast, the public prejudice (49%) was the greatest barriers in the senior group.

Conclusions
Although structural discrimination may most contribute to barriers to visiting psychiatrists in Korea, variation by generations may exist. Along with the general attempt to tackle the discrimination, customized approach might be needed.
Modular reactivation of Mexico City after COVID-19 lockdown
Authors: de Anda-Jáuregui Guillermo , García-García Lourdes , Hernández-Lemus Enrique 
Published: May 2022

Abstract
Background
During the COVID-19 pandemic, the slope of the epidemic curve in Mexico City has been quite unstable. Changes in human activity led to changes in epidemic activity, hampering attempts at economic and general reactivation of the city.

Methods
We have predicted that where a fraction of the population above a certain threshold returns to the public space, the negative tendency of the epidemic curve will revert. Such predictions were based on modeling the reactivation of economic activity after lockdown using an epidemiological model resting upon a contact network of Mexico City derived from mobile device co-localization. We modeled scenarios with different proportions of the population returning to normalcy. Null models were built using the Jornada Nacional de Sana Distancia (the Mexican model of elective lockdown). There was a mobility reduction of 75% and no mandatory mobility restrictions.

Results
We found that a new peak of cases in the epidemic curve was very likely for scenarios in which more than 5% of the population rejoined the public space. The return of more than 50% of the population synchronously will unleash a magnitude similar to the one predicted with no mitigation strategies. By evaluating the tendencies of the epidemic dynamics, the number of new cases registered, hospitalizations, and recent deaths, we consider that reactivation following only elective measures may not be optimal under this scenario.

Conclusions
Given the need to resume economic activities, we suggest alternative measures that minimize unnecessary contacts among people returning to the public space. We evaluated that “encapsulating” reactivated workers (that is, using measures to reduce the number of contacts beyond their influential community in the contact network) may allow reactivation of a more significant fraction of the population without compromising the desired tendency in the epidemic curve.

Graphical Abstract
A multisectoral approach to advance health equity in rural northern Arizona: county-level leaders’ perspectives on health equity
Authors: Jiménez Dulce J. , Sabo Samantha , Remiker Mark , Smith Melinda , Samarron Longorio Alexandra E. , Williamson Heather J. , Chief Carmenlita , Teufel-Shone Nicolette I. 
Published: May 2022

Abstract
Background
Multisectoral and public–private partnerships are critical in building the necessary infrastructure, policy, and political will to ameliorate health inequity. A focus on health equity by researchers, practitioners, and decision-makers prioritizes action to address the systematic, avoidable, and unjust differences in health status across population groups sustained over time and generations that are beyond the control of individuals. Health equity requires a collective process in shaping the health and wellbeing of the communities in which we live, learn, work, play, and grow. This paper explores multisectoral leaders’ understanding of the social, environmental, and economic conditions that produce and sustain health inequity in northern Arizona, a geographically expansive, largely rural, and culturally diverse region.

Methods
Data are drawn from the Southwest Health Equity Research Collaborative’s Regional Health Equity Survey (RHES). The RHES is a community-engaged, cross-sectional online survey comprised of 31 close-ended and 17 open-ended questions. Created to assess cross-sectoral regional and collective capacity to address health inequity and inform multisectoral action for improving community health, the RHES targeted leaders representing five rural northern Arizona counties and 13 sectors. Select open-ended questions were analyzed using an a priori coding scheme and emergent coding with thematic analysis.

Results
Although leaders were provided the definition and asked to describe the root causes of inequities, the majority of leaders described social determinants of health (SDoH). When leaders described root causes of health inequity, they articulated systemic factors affecting their communities, describing discrimination and unequal allocation of power and resources. Most leaders described the SDoH by discussing compounding factors of poverty, transportation, housing, and rurality among others, that together exacerbate inequity. Leaders also identified specific strategies to address SDoH and advance health equity in their communities, ranging from providing direct services to activating partnerships across organizations and sectors in advocacy for policy change.

Conclusion
Our findings indicate that community leaders in the northern Arizona region acknowledge the importance of multisectoral collaborations in improving health equity for the populations that they serve. However, a common understanding of health equity remains to be widely established, which is essential for conducting effective multisectoral work to advance health equity.
Impaired expression of BCAT1 relates to muscle atrophy of mouse model of sarcopenia
Authors: Ouyang Hui , Gao Xuguang , Zhang Jun 
Published: May 2022

Abstract
Background
The underlying mechanism of muscle atrophy in sarcopenia is still not fully understood; branched chain aminotransferase 1(BCAT1) isocitrate dehydrogenase-1 encodes an evolutionarily conserved cytoplasmic aminotransferase for glutamate and branched-chain amino acids (BCAAs), thus constituting a regulatory component of cytoplasmic amino and keto acid metabolism. In human gliomas carrying wild-type isocitrate dehydrogenase-1, BCAT1 promotes cell proliferation through amino acid catabolism. Hence, the goals of this study were to unravel the potential role of BCAT1 expression in muscle atrophy and to explore the mechanisms underlying this process.

Methods
We first measured Bcat1 expression by RT-qPCR and western blotting in murine and cellular models of muscle atrophy. To understand how the Bcat1-driven changes sustained muscle cell growth, we analyzed reactive oxygen species (ROS) levels and activation of the mTORC1/S6K1 pathway in muscle cells. Furthermore, we performed Cell Counting Kit-8(CCK8) assays and fluorescence staining to evaluate growth rate of cells and ROS levels. Finally, we verified that depletion of Bcat1 impairs the growth rate of muscle cells and increases ROS levels, indicating that muscle atrophy resulted from the downregulation of the mTORC1/S6K1 pathway. Data were analyzed by two-tailed unpaired Student’s t-test or Mann-Whitney U test for two groups to determine statistical significance. Statistical analyses were performed using GraphPad Prism version 6.0 and SPSS 16.0 software.

Results
Bcat1 expression level in skeletal muscles was lower in murine and cellular models of sarcopenia than in the control groups. Bcat1 knockdown not only suppressed the growth of muscle cells but also increased the production of ROS. Impaired cell growth and increased ROS production was rescued by co-introduction of an shRNA-resistant Bcat1 cDNA or addition of the mTORC1 stimulator MYH1485. Muscle cells with Bcat1 knockdown featured lower mTORC1 and S6K1 phosphorylation (pS6K1) than NT muscle cells. Addition of either shRNA-resistant Bcat1 cDNA or MYH1485 rescued the suppression of cell growth, increase in ROS production, and decrease in pS6K1.

Conclusions
The branched chain amino acids catabolic enzyme BCAT1 is essential for the growth of muscle cells. BCAT1 expression contributes to sustained growth of muscle cells by activating mTOR signaling and reducing ROS production.
Effect of phytochemical-filled microcapsules with antifungal activity on material properties and dimensional accuracy of denture base resin for three-dimensional printing
Authors: Jeon Sol , Jo Ye-Hyeon , Yoon Hyung-In , Han Jung-Suk 
Published: May 2022

AbstractBackgroundStudies on the material properties and dimensional accuracy of three-dimensionally (3D) printed denture base containing microcapsules with antifungal phytochemicals are lacking.MethodsTwo types of phytochemicals (phytoncide A and B) with antifungal activity were microencapsulated. The 3D-printed denture base specimens with minimum and maximum effective concentrations of microcapsules (6 and 8 wt% for phytoncide A; 15 and 25 wt% for phytoncide B) were prepared. The morphological changes ofC. albicanson 3D-printed denture base with microcapsules was microscopically observed. The degree of conversion of 3D-printed denture base with microcapsules investigated. The microhardness and flexural strength values were also measured to evaluate the mechanical properties of 3D-printed denture bases. The dimensional accuracy (trueness) of the specimens with microcapsules was measured as root-mean-square values (RMS) for the whole, upper, and side surfaces of the specimens as well as their total height. For the degree of conversion, microhardness, and flexural strength values, the Kruskal–Wallis analysis and a post-hoc comparison using Mann–Whitney U test was performed. For the analysis of trueness (RMS), the one-way analysis of variance and a post-hoc comparison using Tukey’s method was conducted (α = 0.05).ResultsAt both maximum and minimum effective concentrations of microcapsules, cell surface disruption or membrane breakdown of fungal cells were observed in the specimens. The groups with microcapsules (both phytoncide A- and B-filled) showed significantly lower microhardness and elastic modulus values than the control group (all, P = 0.001). For the trueness, all the RMS values of the whole, upper, and side surfaces of the specimens with microcapsules were less than 100 µm, although significantly higher than those without (all, P = 0.001). The mean flexural strength values of the groups with phytoncide A-filled microcapsule were higher than 65 MPa, not statistically different from that of the control group (all, P > 0.05). However, the groups with phytoncide B-filled microcapsules showed significantly lower values than the control (all, P = 0.001).ConclusionsWithin the limitations of this in-vitro study, the 3D-printed denture base containing 6 wt% of phytoncide A-filled microcapsules was clinically acceptable in terms of antifungal activity, dimensional accuracy, and flexural strength.
A social network intervention to improve connectivity and burnout among psychiatry residents in an academic institution: a quasi-experimental study
Authors: Aghaei Ardavan Mohammad , Sharifi Vandad , Tabatabaee Maryam , Abdi-Masouleh Fattaneh , Nooraie Reza Yousefi 
Published: May 2022

Abstract
Background
Burnout is common among residents, which could be associated with their professional network characteristics. This study aimed to assess the social networks of psychiatry residents and develop an intervention to improve their network characteristics, burnout, and perception of the educational environment.

Methods
We recruited a cohort of 17 PGY-2 residents and assessed their social networks, burnout, and perception of the educational environment. After the baseline survey, we held a focus group with PGY-2 residents to discuss the results, their network characteristics, and interventions that can improve their relationships. The PGY-2 residents indicated that offering extracurricular opportunities to facilitate friendly interactions among the residents and faculty members would be the most feasible and acceptable intervention. Therefore, four “interest groups” for extracurricular activities were established. Residents and faculty members were invited to participate in interest groups to improve the network characteristics. Some PGY-2 residents and faculty members agreed to moderate interest group sessions (active members).

Results
After the intervention, active residents improved significantly in the perceived personal accomplishment subscale of the burnout inventory and their perception of the educational environment. Active faculty members also had a significant increase in their relationships with PGY-2 residents in one domain of social networks.

Conclusions
Enhancing relationships between residents and faculty members through participatory intervention and extracurricular activities can improve faculty-resident connectivity and residents’ perception of personal accomplishment and educational environment quality.
The development of a patient decision aid to reduce decisional conflict about antidepressant use in pregnancy
Authors: Hussain-Shamsy Neesha , Somerton Sarah , Stewart Donna E. , Grigoriadis Sophie , Metcalfe Kelly , Oberlander Tim F. , Schram Carrie , Taylor Valerie H. , Dennis Cindy-Lee , Vigod Simone N. 
Published: May 2022

Abstract
Background
People with moderate to severe depression in pregnancy must weigh potential risks of untreated or incompletely treated depression against the small, but uncertain risks of fetal antidepressant drug exposure. Clinical support alone appears insufficient for helping individuals with this complex decision. A patient decision aid (PDA) has the potential to be a useful tool for this population. The objective of our work was to use internationally recognized guidelines from the International Patient Decision Aids Standards Collaboration to develop an evidence-based PDA for antidepressant use in pregnancy.

Methods
A three-phased development process was used whereby, informed by patient and physician perspectives and evidence synthesis, a steering committee commissioned a web-based PDA for those deciding whether or not to start or continue antidepressant treatment for depression in pregnancy (Phase 1). A prototype was developed (Phase 2) and iteratively revised based on feedback during field testing based on a user-centred process (Phase 3).

Results
We developed a web-based PDA for people deciding whether to start or continue antidepressant use for depression in pregnancy. It has five interactive sections: (1) information on depression and treatment; (2) reasons to start/continue an antidepressant and to start/stop antidepressant medication; (3) user assessment of values regarding each issue; (4) opportunity to reflect on factors that contribute to decision making; and (5) a printable PDF that summarizes the user’s journey through the PDA.

Conclusions
This tool, which exclusively focuses on depression treatment with Selective Serotonin Reuptake Inhibitors and Serotonin–Norepinephrine Reuptake Inhibitors, can be used by individuals making decisions about antidepressant use to treat depression during pregnancy. Limitations of the PDA are that it is not for other conditions, nor other medications that can be used for depression, and in its pilot form cannot be used by women who do not speak English or who have a visual impairment. Pending further study, it has the potential to enhance quality of care and patient experience.
Barriers and facilitators to implementing a continuing medical education intervention in a primary health care setting
Authors: Reis Teresa , Faria Inês , Serra Helena , Xavier Miguel 
Published: May 2022

Abstract
Background
Continuing medical education (CME), as a systematic attempt to facilitate change in General Practitioners’ (GPs) practices, is considered crucial, assuming that if physicians are up-to-date, they will change and improve their practice, resulting in better performance and ultimately better patient care. However, studies continue to demonstrate considerable gaps between the real and ideal performance and patient-related outcomes. The objective of this study was to explore GP’s perception of the factors affecting the implementation of a CME digital platform in a primary health care setting in Portugal.

Methods
Our work is framed in a larger effectiveness-implementation hybrid type 1 study, where a Digital Behaviour Change Intervention (DBCI), called ePrimaPrescribe, was developed and implemented with the aim of changing benzodiazepines (BZD) prescribing patterns. Our design used mixed methodologies to obtain an enriched knowledge on GPs’ perspectives on the facilitators and barriers to implementing a Digital Behaviour Change Intervention (DBCI) applied to CME. To do so, we used data coming from an onsite questionnaire, an adapted version of the Barriers and Facilitators Assessment Instrument (BaFAI) and in-depth interviews.

Results
From the 47 GPs successfully included in the intervention arm of our cluster-randomized effectiveness study, we collected 37 onsite questionnaires, 24 BaFAIs, and performed 12 in-depth interviews. GPs reported as the main barriers to CME a lack of time, a perception of work overload, a lack of digital competence, a lack of digital infrastructure, and motivational and emotional factors. They reported as facilitators to CME delivered through a DBCI the convenience of the delivery method, the practical and pragmatic characteristics of the content, and the possibility for CME to be mandatory.

Conclusions
The perceptions of the barriers and facilitators reported by GPs represent an important contribution to improving knowledge regarding the factors influencing the implementation of CME in primary health care settings. We consider that our study might bring useful insights to other countries where primary health care plays a central role in the provision of care.

Trial registration
ClinicalTrials.gov number NCT04925596.
Opsin1 regulates light-evoked avoidance behavior in Aedes albopictus
Authors: Liu Xinyi , Yang Shuzhen , Yao Yuan , Wu Si , Wu Pa , Zhai Zongzhao 
Published: May 2022

Abstract
Background
Mosquitoes locate a human host by integrating various sensory cues including odor, thermo, and vision. However, their innate light preference and its genetic basis that may predict the spatial distribution of mosquitoes, a prerequisite to encounter a potential host and initiate host-seeking behaviors, remains elusive.

Results
Here, we first studied mosquito visual features and surprisingly uncovered that both diurnal (Aedes aegypti and Aedes albopictus) and nocturnal (Culex quinquefasciatus) mosquitoes significantly avoided stronger light when given choices. With consistent results from multiple assays, we found that such negative phototaxis maintained throughout development to adult stages. Notably, female mosquitoes significantly preferred to bite hosts in a shaded versus illuminated area. Furthermore, silencing Opsin1, a G protein-coupled receptor that is most enriched in compound eyes, abolished light-evoked avoidance behavior of Aedes albopictus and attenuated photonegative behavior in Aedes aegypti. Finally, we found that field-collected Aedes albopictus also prefers darker area in an Opsin1-dependent manner.

Conclusions
This study reveals that mosquitoes consistently prefer darker environment and identifies the first example of a visual molecule that modulates mosquito photobehavior.
Sucking and drinking behaviour in preweaned dairy calves in the first five weeks of life
Authors: Braun Ueli , Kochan Manon , Kaske Martin , Gerspach Christian , Bleul Ulrich 
Published: May 2022

Abstract
Background
Nursing and sucking are essential for adequate nourishment of preweaned calves and the relationship between sucking indices has not been studied. The goal of this study was to investigate the number of sucks per litre of milk and per minute of drinking and the amount of milk ingested per suck in healthy preweaned calves. Correlation coefficients were calculated for the relationships between these variables. Eighteen healthy calves were used from birth to 5 weeks of age, and five measurements were made at the end of weeks 1 to 5. The calves were randomly divided into three groups and offered milk twice daily in a bucket with a rubber nipple. The amount of milk offered per day was equal to 12% of body weight in group A and 16% of body weight in group B. Calves in group C were offered as much milk as they wanted during each feeding period. The duration of drinking was determined with a stopwatch, and the number of sucks was counted with a handheld tally counter. The variables drinking duration, total amount consumed and the number of sucks required were used to calculate the number of sucks/min, the number of sucks/L, the amount ingested per suck and drinking speed.

Results
The number of sucks/min ranged from 113 to 133 and increased significantly during the study period. The mean number of sucks/L decreased from 204 in week 1 to 141 in week 5 and drinking speed increased from 0.6 to 1.0 L/min. There were significant correlations between the number of sucks/L of milk and the amount of milk ingested per suck, drinking duration, total amount consumed and drinking speed. Drinking speed was positively correlated with the amount of milk ingested per suck and the total amount of milk consumed, and negatively correlated with drinking duration.

Conclusions
These findings show that drinking variables of calves offered different amounts of milk vary little and significant changes occur during the same period with respect to the number of sucks/L of milk and the amount of milk ingested per suck. Several drinking variables are significantly correlated with other variables.