bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-Bandgap Monolithic Metal Nanowire Percolation Network Sensor Integration by Reversible Selective Laser-Induced Redox
Authors: Bang Junhyuk , Jung Yeongju , Kim Hyungjun , Kim Dongkwan , Cho Maenghyo , Ko Seung Hwan 
Published: January 2022

AbstractActive electronics are usually composed of semiconductor and metal electrodes which are connected by multiple vacuum deposition steps and photolithography patterning. However, the presence of interface of dissimilar material between semiconductor and metal electrode makes various problems in electrical contacts and mechanical failure. The ideal electronics should not have defective interfaces of dissimilar materials. In this study, we developed a novel method to fabricate active electronic components in a monolithic seamless fashion where both metal and semiconductor can be prepared from the same monolith material without creating a semiconductor–metal interface by reversible selective laser-induced redox (rSLIR) method. Furthermore, rSLIR can control the oxidation state of transition metal (Cu) to yield semiconductors with two different bandgap states (Cu2O and CuO with bandgaps of 2.1 and 1.2 eV, respectively), which may allow multifunctional sensors with multiple bandgaps from the same materials. This novel method enables the seamless integration of single-phase Cu, Cu2O, and CuO, simultaneously while allowing reversible, selective conversion between oxidation states by simply shining laser light. Moreover, we fabricated a flexible monolithic metal–semiconductor–metal multispectral photodetector that can detect multiple wavelengths. The unique monolithic characteristics of rSLIR process can provide next-generation electronics fabrication method overcoming the limitation of conventional photolithography methods.
Crystal Facet Engineering of TiO2 Nanostructures for Enhancing Photoelectrochemical Water Splitting with BiVO4 Nanodots
Authors: Lee Mi Gyoung , Yang Jin Wook , Park Hoonkee , Moon Cheon Woo , Andoshe Dinsefa M. , Park Jongseong , Moon Chang-Ki , Lee Tae Hyung , Choi Kyoung Soon , Cheon Woo Seok , Kim Jang-Joo , Jang Ho Won 
Published: January 2022

AbstractAlthough bismuth vanadate (BiVO4) has been promising as photoanode material for photoelectrochemical water splitting, its charge recombination issue by short charge diffusion length has led to various studies about heterostructure photoanodes. As a hole blocking layer of BiVO4, titanium dioxide (TiO2) has been considered unsuitable because of its relatively positive valence band edge and low electrical conductivity. Herein, a crystal facet engineering of TiO2 nanostructures is proposed to control band structures for the hole blocking layer of BiVO4 nanodots. We design two types of TiO2 nanostructures, which are nanorods (NRs) and nanoflowers (NFs) with different (001) and (110) crystal facets, respectively, and fabricate BiVO4/TiO2 heterostructure photoanodes. The BiVO4/TiO2 NFs showed 4.8 times higher photocurrent density than the BiVO4/TiO2 NRs. Transient decay time analysis and time-resolved photoluminescence reveal the enhancement is attributed to the reduced charge recombination, which is originated from the formation of type II band alignment between BiVO4 nanodots and TiO2 NFs. This work provides not only new insights into the interplay between crystal facets and band structures but also important steps for the design of highly efficient photoelectrodes.
Quantitative considerations about the size dependence of cellular entry and excretion of colloidal nanoparticles for different cell types
Authors: Kang Yanan , Nack Leroy Marwin , Liu Yang , Qi Bing , Huang Yalan , Liu Ziyao , Chakraborty Indranath , Schulz Florian , Ahmed Abdullah A. A. , Clavo Poveda Mirco , Hafizi Fereshta , Roy Sathi , Mutas Marina , Holzapfel Malte , Sanchez-Cano Carlos , Wegner K. David , Feliu Neus , Parak Wolfgang J. 
Published: January 2022

AbstractMost studies about the interaction of nanoparticles (NPs) with cells have focused on how the physicochemical properties of NPs will influence their uptake by cells. However, much less is known about their potential excretion from cells. However, to control and manipulate the number of NPs in a cell, both cellular uptake and excretion must be studied quantitatively. Monitoring the intracellular and extracellular amount of NPs over time (after residual noninternalized NPs have been removed) enables one to disentangle the influences of cell proliferation and exocytosis, the major pathways for the reduction of NPs per cell. Proliferation depends on the type of cells, while exocytosis depends in addition on properties of the NPs, such as their size. Examples are given herein on the role of these two different processes for different cells and NPs.
Das Narrativ der unaufhaltsam steigenden Ungleichheit geht an der Lebenswirklichkeit der meisten Menschen vorbei
Authors: Wagner Gert G. 
Published: January 2022

ZusammenfassungIn diesem Artikel wird diskutiert, warum das weit verbreitete Narrativ einer wachsenden ökonomischen Ungleichheit in Deutschland nicht zu einer Stärkung der entsprechenden politischen Kräfte (SPD, Linkspartei und Gewerkschaften) geführt hat. Der Fokus liegt dabei nicht auf politischen Widerständen und Gegenkräften, die es bezüglich mehr Gleichheit zweifelsohne gab und gibt, sondern auf der Gültigkeit des Narrativs. Es zeigt sich, dass es methodisch und empirisch wenig robust ist und – gemessen an der Lebenszufriedenheit der Menschen in Deutschland – an der Lebenswirklichkeit der Mehrheit vorbeigeht. Zumindest war dies bis zum Beginn der Corona-Pandemie der Fall. Der Artikel leugnet keineswegs nicht oder nur schwer zu rechtfertigende Ungleichheiten, er soll aber deutlich machen, dass es weder methodisch noch empirisch gerechtfertigt ist, von einer unaufhaltsamen unerwünschten Zunahme der ökonomischen Ungleichheit in Deutschland zu sprechen. Will man die Ungleichheit substanziell verkleinern oder zumindest abmildern, bedarf es nach Überzeugung des Autors eines Narrativs, das methodisch und empirisch belastbar ist und das zugleich die Mittelschicht, ohne die keine politischen Mehrheiten möglich sind, erreicht und so genügend Wählerinnen und Wähler in der Mitte u. a. von einer gezielten Umverteilung überzeugt. Der Artikel macht abschliessend Vorschläge für die Verbesserung der empirischen Grundlagen der Messung und Analyse von ökonomischen Ungleichheiten und der Kommunikation der entsprechenden Analyseergebnisse. Prolog und Epilog versuchen aus persönlicher Sicht des Autors eine politische Einordnung der methodischen und empirischen Überlegungen vorzunehmen.
JAX-CNV: A Whole-Genome Sequencing-Based Algorithm for Copy Number Detection at Clinical Grade Level
Authors: Lee Wan-Ping , Zhu Qihui , Yang Xiaofei , Liu Silvia , Cerveira Eliza , Ryan Mallory , Mil-Homens Adam , Bellfy Lauren , Ye Kai , Lee Charles , Zhang Chengsheng 
Published: January 2022

Abstract
We aimed to develop a whole-genome sequencing (WGS)-based copy number variant (CNV) calling algorithm with the potential of replacing chromosomal microarray assay (CMA) for clinical diagnosis. JAX-CNV is thus developed for CNV detection from WGS data. The performance of this CNV calling algorithm was evaluated in a blinded manner on 31 samples and compared to the 112 CNVs reported by clinically validated CMAs for these 31 samples. The result showed that JAX-CNV recalled 100% of these CNVs. Besides, JAX-CNV identified an average of 30 CNVs per individual, respresenting an approximately seven-fold increase compared to calls of clinically validated CMAs. Experimental validation of 24 randomly selected CNVs showed one false positive, i.e., a false discovery rate (FDR) of 4.17%. A robustness test on lower-coverage data revealed a 100% sensitivity for CNVs larger than 300 kb (the current threshold for College of American Pathologists) down to 10× coverage. For CNVs larger than 50 kb, sensitivities were 100% for coverages deeper than 20×, 97% for 15×, and 95% for 10×. We developed a WGS-based CNV pipeline, including this newly developed CNV caller JAX-CNV, and found it capable of detecting CMA-reported CNVs at a sensitivity of 100% with about a FDR of 4%. We propose that JAX-CNV could be further examined in a multi-institutional study to justify the transition of first-tier genetic testing from CMAs to WGS. JAX-CNV is available at https://github.com/TheJacksonLaboratory/JAX-CNV.
ASpediaFI: Functional Interaction Analysis of Alternative Splicing Events
Authors: Lee Kyubin , Yu Doyeong , Hyung Daejin , Cho Soo Young , Park Charny 
Published: January 2022

Abstract
Alternative splicing (AS) regulates biological processes governing phenotypes and diseases. Differential AS (DAS) gene test methods have been developed to investigate important exonic expression from high-throughput datasets. However, the DAS events extracted using statistical tests are insufficient to delineate relevant biological processes. In this study, we developed a novel application, Alternative Splicing Encyclopedia: Functional Interaction (ASpediaFI), to systemically identify DAS events and co-regulated genes and pathways. ASpediaFI establishes a heterogeneous interaction network of genes and their feature nodes (i.e., AS events and pathways) connected by co-expression or pathway gene set knowledge. Next, ASpediaFI explores the interaction network using the random walk with restart algorithm and interrogates the proximity from a query gene set. Finally, ASpediaFI extracts significant AS events, genes, and pathways. To evaluate the performance of our method, we simulated RNA sequencing (RNA- seq) datasets to consider various conditions of sequencing depth and sample size. The performance was compared with that of other methods. Additionally, we analyzed three public datasets of cancer patients or cell lines to evaluate how well ASpediaFI detects biologically relevant candidates. ASpediaFI exhibits strong performance in both simulated and public datasets. Our integrative approach reveals that DAS events that recognize a global co-expression network and relevant pathways determine the functional importance of spliced genes in the subnetwork. ASpediaFI is publicly available at https://bioconductor.org/packages/ASpediaFI.
Divide and conquer: spatially fractionated radiation therapy
Authors: Prezado Yolanda 
Published: January 2022

AbstractSpatially fractionated radiation therapy (SFRT) challenges some of the classical dogmas in conventional radiotherapy. The highly modulated spatial dose distributions in SFRT have been shown to lead, both in early clinical trials and in small animal experiments, to a significant increase in normal tissue dose tolerances. Tumour control effectiveness is maintained or even enhanced in some configurations as compared with conventional radiotherapy. SFRT seems to activate distinct radiobiological mechanisms, which have been postulated to involve bystander effects, microvascular alterations and/or immunomodulation. Currently, it is unclear which is the dosimetric parameter which correlates the most with both tumour control and normal tissue sparing in SFRT. Additional biological experiments aiming at parametrizing the relationship between the irradiation parameters (beam width, spacing, peak-to-valley dose ratio, peak and valley doses) and the radiobiology are needed. A sound knowledge of the interrelation between the physical parameters in SFRT and the biological response would expand its clinical use, with a higher level of homogenisation in the realisation of clinical trials. This manuscript reviews the state of the art of this promising therapeutic modality, the current radiobiological knowledge and elaborates on future perspectives.
How History Wars Shape Foreign Policy: An Ancient Kingdom and the Future of China–South Korea Relations
Authors: Gries Peter , Masui Yasuki 
Published: January 2022

AbstractDo history wars shape international affairs? If so, how and for whom? Taking the historical dispute between China and South Korea over the ancient Gaogouli/Goguryeo Kingdom as a case study, this article explores the individual-level psychological micro-foundations of history wars. A 2020 survey experiment in South Korea pit “ours” vs “theirs” Goguryeo imitation Wikipedia entries to explore their downstream consequences. It revealed direct, indirect, and conditional effects. Exposure to China's claim to the Kingdom undermined Korean pride, increasing dislike of China, and lessening desires to cooperate with it. Pre-existing levels of nationalism divided South Koreans in how angry they became after exposure the Wikipedia primes. That anger, however, only shaped the China policy preferences of those South Koreans who viewed the balance of military power with China favorably. Implications for ownership disputes over kimchi and other national possessions are also discussed, as are the implications of history wars for war and peace in twenty-first-century East Asia.
The Carboniferous conodont Lochriea commutata (Branson and Mehl, 1941), the type species of Lochriea Scott, 1942: nomenclatural history, apparatus composition and effects on Lochriea species
Authors: von Bitter Peter H. , Norby Rodney D. , Stamm Robert G. 
Published: January 2022

AbstractLochriea commutata (Branson and Mehl, 1941), a senior subjective synonym of Lochriea montanaensis Scott, 1942, is the type species of Lochriea Scott, 1942, one of the first conodont genera named using bedding-plane assemblages. Lochriea commutata is both wide- and long-ranging, locally stratigraphically important, and a consistently recognized Carboniferous species, despite its taxonomic journey from Spathognathodus to Gnathodus to Paragnathodus to Lochriea.Lochriea commutata was, as Lochriea montanaensis, initially reported to contain 22+ elements, the apparatus composition of the genus being subsequently amended to 17+ elements based on Lochriea wellsi Melton and Scott, 1973, which is an untenable hypothesis because the latter was a conodontophage. Restudy of original and new bedding-plane assemblages in the mid 1970s established that the first assemblages studied were fecal, the initial reconstruction incorporated elements of two individuals, and Lochriea commutata possessed a feeding apparatus of 2P1, 2P2, 2M, 2S1, 2S2, 2S3, 2S4, and 1S0 elements. A Lochriea sp. bedding-plane assemblage was subsequently found to have the same element composition, and restudy of type material, available bedding-plane assemblages, and new fused clusters confirms that Lochriea commutata had a 15-element ozarkodinid apparatus.While species are still assigned to Lochriea using carminiscaphate P1 elements almost exclusively, those assignments must be considered tentative until their apparatuses are determined to be similar to that of L. commutata, and until characteristics of elements other than the P1 element, particularly the makellate M element and the bipennate S3/4 element, are also taken into account.Lochriea bigsnowyensis Scott, 1942 is reassigned to Cavusgnathus Harris and Hollingsworth, 1933.
Cheating in online gaming spreads through observation and victimization
Authors: Kim Ji Eun , Tsvetkova Milena 
Published: January 2022

AbstractAntisocial behavior can be contagious, spreading from individual to individual and rippling through social networks. Moreover, it can spread not only through third-party influence from observation, just like innovations or individual behavior do, but also through direct experience, via “pay-it-forward” retaliation. Here, we distinguish between the effects of observation and victimization for the contagion of antisocial behavior by analyzing large-scale digital trace data. We study the spread of cheating in more than a million matches of an online multiplayer first-person shooter game, in which up to 100 players compete individually or in teams against strangers. We identify event sequences in which a player who observes or is killed by a certain number of cheaters starts cheating and evaluate the extent to which these sequences would appear if we preserve the team and interaction structure but assume alternative gameplay scenarios. The results reveal that social contagion is only likely to exist for those who both observe and experience cheating, suggesting that third-party influence and “pay-it-forward” reciprocity interact positively. In addition, the effect is present only for those who both observe and experience more than once, suggesting that cheating is more likely to spread after repeated or multi-source exposure. Approaching online games as models of social systems, we use the findings to discuss strategies for targeted interventions to stem the spread of cheating and antisocial behavior more generally in online communities, schools, organizations, and sports.
Natural Selection of Independently Originated Life Clades
Authors: Hermida Margarida 
Published: January 2022

AbstractLife on Earth descends from a common ancestor. However, it is likely that there are other instances of life in the universe. If so, each abiogenesis event will have given rise to an independently originated life clade (IOLC), of which Earth-life is an example. In this paper, I argue that the set of all IOLCs in the universe forms a Darwinian population subject to natural selection, with more widely dispersed IOLCs being less likely to face extinction. As a result, we should expect that, over time, more planets will become inhabited by fewer, more successful IOLCs.
RADIOCARBON DATING ROZHOK I, A MIDDLE PALEOLITHIC OPEN-AIR SITE IN SOUTHERN RUSSIA
Authors: Otcherednoy A K , Nehoroshev P E , Vishnyatsky L B , Voskresenskaya E V , Southon J R , Hoffecker J F 
Published: January 2022

ABSTRACTSamples of bone and teeth from the Middle Paleolithic open-air site of Rozhok I, located on the Gulf of Taganrog, were dated by radiocarbon (14C). We obtained 26 accelerator mass spectrometry (AMS) dates on a large sample of nonhuman bone and teeth recovered by N. D. Praslov during 1961–1962 from 5 of the 6 occupation horizons at Rozhok I. Two rigorous pretreatment methods were applied to the samples: ultra-filtration and XAD resin. The 14C ages from the uppermost two layers (Horizons 1 and 2) are infinite with the exception of one age near the limit of the 14C method. By contrast, the dates from Horizon 3 and the two lowermost layers (Horizons 5 and 6) are all finite ages and some are less than 45,000 BP (uncalibrated). While there is evidence of some post-depositional disturbance, there is no evidence of a stratigraphic reversal of the cultural layers. The simplest explanation for the pattern is that bones and teeth in the lower layers have been contaminated by groundwater containing young carbon. We conclude that Rozhok I probably antedates 50,000 cal BP and is beyond the range of 14C dating.
Duke Leopold of Lorraine, Small State Diplomacy, and the Stuart Court in Exile, 1716–1729
Authors: Griffin Stephen 
Published: January 2022

AbstractThis article examines how rulers of early modern small states attempted to survive and increase their status in the ever-shifting political world of early eighteenth-century Europe. To do so it takes the example of Duke Leopold of Lorraine and his connections with the exiled James Francis Edward Stuart and his court. Like many other small state princes, Leopold was politically dependent upon the decisions of his larger neighbours and his policies were designed to ensure his continued survival and to increase his own prestige. Historians have long acknowledged the relationship between Leopold and James in 1713–15 but they have done little to explore their interactions between 1716 and 1729. In drawing attention to this neglected sequence of encounters, the article highlights their connection to broader and more well-known political affairs in the 1710s and 1720s. It demonstrates how Leopold utilized his connection with the Stuarts as he reacted to a changing political situation in Europe in the years following the Peace of Utrecht. In return, the Stuarts, seeking to achieve their political goals, could rely upon ducal advice and aid. This dynamic suggests that these small but well-connected princes and their diplomatic activities require further consideration when examining international relations.
Evaluating the interactive effects of dietary habits and human gut microbiome on the risks of depression and anxiety
Authors: Yao Yao , Qi Xin , Jia Yumeng , Ye Jing , Chu Xiaomeng , Wen Yan , Cheng Bolun , Cheng Shiqiang , Liu Li , Liang Chujun , Wu Cuiyan , Wang Xi , Ning Yujie , Wang Sen , Zhang Feng 
Published: January 2022

AbstractBackgroundGut microbiome and dietary patterns have been suggested to be associated with depression/anxiety. However, limited effort has been made to explore the effects of possible interactions between diet and microbiome on the risks of depression and anxiety.MethodsUsing the latest genome-wide association studies findings in gut microbiome and dietary habits, polygenic risk scores (PRSs) analysis of gut microbiome and dietary habits was conducted in the UK Biobank cohort. Logistic/linear regression models were applied for evaluating the associations for gut microbiome-PRS, dietary habits-PRS, and their interactions with depression/anxiety status and Patient Health Questionnaire (PHQ-9)/Generalized Anxiety Disorder-7 (GAD-7) score by R software.ResultsWe observed 51 common diet–gut microbiome interactions shared by both PHQ score and depression status, such as overall beef intake × genus Sporobacter [hurdle binary (HB)] (PPHQ = 7.88 × 10−4, Pdepression status = 5.86 × 10−4); carbohydrate × genus Lactococcus (HB) (PPHQ = 0.0295, Pdepression status = 0.0150). We detected 41 common diet–gut microbiome interactions shared by GAD score and anxiety status, such as sugar × genus Parasutterella (rank normal transformed) (PGAD = 5.15 × 10−3, Panxiety status = 0.0347); tablespoons of raw vegetables per day × family Coriobacteriaceae (HB) (PGAD = 6.02 × 10−4, Panxiety status = 0.0345). Some common significant interactions shared by depression and anxiety were identified, such as overall beef intake × genus Sporobacter (HB).ConclusionsOur study results expanded our understanding of how to comprehensively consider the relationships for dietary habits–gut microbiome interactions with depression and anxiety.
Algebras of UTxO blockchains
Authors: Gabbay Murdoch J. 
Published: January 2022

AbstractWe condense the theory of UTxO blockchains down to a simple and compact set of four type equations (Idealised EUTxO), and to an algebraic characterisation (abstract chunk systems), and exhibit an adjoint pair of functors between them. This gives a novel account of the essential mathematical structures underlying blockchain technology, such as Bitcoin.