bluuebunny/crossref_metadata_2025_split huggingface dataset:
IS IT POSSIBLE TO MEASURE UNCERTAINTY IN THE HEALTHCARE MARKET?
Authors: ÖZMEN Oğuzhan , ARIKAN Cengiz 
Published: November 2022

The subject of uncertainty is a phenomenon that has been researched and discussed in order to make the market more predictable by providing market balances in a historical process. Uncertainty is an important determinant of enterprise and investment for all kinds of markets, and it is effective at increasing and decreasing levels depending on time and events. However, due to the characteristics of the health services market, it is always considered as a factor that has to be taken into account.
It is considered that the reasons why the concept of uncertainty in the health services market is more pronounced and effective than other markets are mainly due to the various differences in the field of health services, and an acceptance behavior has emerged about the concept of uncertainty in health services.
In this study, the "uncertainty measures" that can be applied to other markets were evaluated as applicable to the health services market, and health markets were evaluated in terms of uncertainty measures in other markets, based on the hypothesis of "Uncertainty cannot be measured in the Health Services Market". In the study, primarily, the definition of uncertainty in terms of the health services market was made, and the sources of uncertainty in the health market were tried to be determined as in other markets. The most frequently used uncertainty measures have been adapted to the health service market actors about the health services market uncertainty arising from these sources, and in this way, the measurability, quantification, and formulalability of the uncertainty in the health services market have been examined.
As a result; Quantitative measurement of uncertainty in the healthcare market and making a numerical estimation of the expected uncertainty processes are hypothetically possible. Thanks to the determinable and predictable healthcare market uncertainty values, all actors in the healthcare market will have a higher level of knowledge in decision-making processes, face lower costs in a more balanced market, and make less risky investments.
LC-MS/MS Analytical Method for Determination of Montelukast in Human
Plasma and its Application to a Bioequivalence Study
Authors: Said Rana 
Published: November 2022

Background:
This study aimed to develop a sensitive, rapid method based on HPLC-MS/MS
for the quantification of Montelukast in human plasma utilizing Montelukast-D6 as an internal standard.
Montelukast is a leukotriene inhibitor and is used to prevent asthma attacks in adults and children.

Method:
Separation was achieved using Thermo Hypersil GOLD™ Cyano HPLC columns (50 ×
4.6 mm; 5 μm) with a mobile phase consisting of 0.5 mM ammonium chloride: ACN (20:80%; v/v).

Results:
The method was found to be linear over a concentration range of 10.0 - 600.0 ng/mL
with a correlation coefficient (r2) ≥ 0. 0.9989. The stabilities of Montelukast and internal standard
were assessed in several conditions with recovery results > 85%. The precision results
were less than 4.0%, while the accuracy results were within 93.0 107.0%. The method proved to
be selective with no matrix effect.

Conclusion:
This method was found to be highly reproducible and was utilized successfully for
the analysis of plasma samples following the oral administration of Montelukast (10 mg) in 28
healthy male human volunteers.
Trimethylamine N-Oxide as a Potential Risk Factor for Non-communicable
Diseases: A Systematic Review
Authors: Hoseini-Tavassol Zahra , Ejtahed Hanieh-Sadat , Larijani Bagher , Hasani-Ranjbar Shirin 
Published: November 2022

Background:
Trimethylamine N-Oxide (TMAO), as a gut microbiota-derived metabolite,
has been associated with a number of chronic diseases like cardiovascular diseases.

Objective:
Considering the increasing prevalence of non-communicable diseases (NCDs), we conducted
a systematic review to discuss the TMAO association with NCDs.

Methods:
A comprehensive search has been conducted on PubMed, Web of Science, and Scopus
databases up to December, 2020. The inclusion criteria were all related observational studies that
surveyed the association between TMAO levels and non-communicable diseases. Interventional
studies, animal experiments, reviews, case reports, letters, congress abstracts, and studies that were
not published in English were excluded. Moreover, related review studies were separately discussed.

Results:
Within 2191 recorded studies, 99 cross-sectional, case-control and cohort studies met the
inclusion criteria. The most common diseases associated with TMAO levels are cardiovascular
diseases, diabetes, kidney disease, stroke, inflammatory diseases, neurological disorders, and
cancer. Elevated TMAO levels as a consequence of alteration in gut microbiota composition and
dietary intake can lead to the incidence of NCDs. The high levels of TMAO can disrupt the homeostasis
of glucose and lipids and induce inflammation that leads to serious NCDs.

Conclusion:
There is a dose-response relationship between TMAO levels and NCDs progression.
Therefore, it can be studied as a therapeutic target or prognostic biomarker for dealing with NCDs.
The Treatment of Parkinson’s Disease with Sodium Oxybate
Authors: Mamelak Mortimer 
Published: November 2022

Abstract:
Sodiun Oxybate (SO) has a number of attributes that may mitigate the metabolic stress on
the substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons in Parkinson’s disease (PD).
These neurons function at the borderline of energy sufficiency. SO is metabolized to succinate and
supplies energy to the cell by generating ATP. SO is a GABAB agonist and, as such, also arrests the
high energy requiring calcium pace-making activity of these neurons. In addition, blocking calcium
entry impedes the synaptic release and subsequent neurotransmission of aggregated synuclein species.
As DA neurons degenerate, a homeostatic failure exposes these neurons to glutamate excitotoxicity,
which in turn accelerates the damage. SO inhibits the neuronal release of glutamate and blocks its
agonistic actions. Most important, SO generates NADPH, the cell’s major antioxidant cofactor. Excessive
free radical production within DA neurons and even more so within activated microglia are early
and key features of the degenerative process that are present long before the onset of motor symptoms.
NADPH maintains cell glutathione levels and alleviates oxidative stress and its toxic consequences.
SO, a histone deacetylase inhibitor also suppresses the expression of microglial NADPH oxidase, the
major source of free radicals in Parkinson brain. The acute clinical use of SO at night has been shown
to reduce daytime sleepiness and fatigue in patients with PD. With long-term use, its capacity to supply
energy to DA neurons, impede synuclein transmission, block excitotoxicity and maintain an anti-oxidative
redox environment throughout the night may delay the onset of PD and slow its progress.
Abordaje de pacientes con síntomas físicos médicamente no explicados (mus). Parte I
Authors: Ramírez-Aranda José Manuel , Martínez-Gutiérrez Cynthia Marlene , Terviño-Uresti Yarezzi Karolina , Escobedo-Gil Juan Manuel 
Published: November 2022

Los pacientes con “síntomas físicos médicamente no explicados” (mus, en inglés) son frecuentes en la consulta médica; estos pacientes acuden a consulta por síntomas inespecíficos, de etiología incierta, sin cuadro clínico definido, exploración física normal para su queja y laboratorio e imagen sin anormalidades. El abordaje de un paciente con mus puede ser todo un desafío, provoca frustración en el médico e insatisfacción en los pacientes; implica mayor costo en la atención y saturación de servicios de salud. Hay varias intervenciones no farmacológicas que han mostrado utilidad. El médico familiar debe adquirir destrezas para atender a estos pacientes. En esta revisión se describen las etapas ordenadas para el abordaje de pacientes con mus como:
1. ¿Qué hacer? Trabajar sobre la reatribución del síntoma. Establecer conexión: entre evento estresante y síntoma(s) inespecífico(s). 2. ¿Cómo hacerlo? Implementar una guía de abordaje: habilidades perceptuales y ejecutivas del profesional tratante. 3. ¿Cuándo hacerlo? (timing). Entrenamiento en práctica de reatribución del síntoma; perspicacia; atención. Es esencial que los pacientes entiendan cómo los problemas psicológicos producen síntomas somáticos, se debe valorar si el paciente está preparado para admitirlo y trabajar sobre su fuente de estrés o evento estresante, también la familia del paciente debe ser valorada.
O que Fazer no Trabalho de Conclusão de Curso? Analisando Escolhas dos Licenciandos em Matemática
Authors: Silva Silvestre Bruno , Silva Maria Marta da , Cedro Wellington Lima 
Published: November 2022

O artigo apresenta-se na temática da formação inicial de professores, no desenvolvimento das tarefas de estudo da docência, sobretudo, relacionado ao trabalho de conclusão de curso. Tem-se como questão de pesquisa a seguinte indagação: quais os motivos que sustentam as escolhas dos licenciandos em matemática pela temática e desenvolvimento do trabalho de conclusão de curso? Conexo ao problema, apresenta-se o objetivo de analisar os motivos que justificam as escolhas dos licenciandos na produção desse trabalho. O texto fundamenta-se com base na teoria histórico-cultural com destaque nos princípios psicológicos e didáticos da teoria da atividade, no desenvolvimento dos motivos e sentidos pessoais diante das significações sociais da formação inicial. A metodologia desenvolve-se por meio de uma intervenção pedagógica formativa realizada com dois sujeitos dessa licenciatura. A produção dos dados tem referente empírico nas transcrições de entrevistas e momentos de orientações coletivas para o desenvolvimento do trabalho acadêmico materializado em formato de artigo. A análise é realizada na perspectiva do materialismo histórico-dialético, que demonstra resultados por meio dos motivos criadores de sentido pelos estudantes sobre suas vivências e experiências no desenvolvimento da formação inicial, sobretudo durante os processos formativos ao longo da graduação. Além desses casos, também foram observados o convencimento dos pares, demonstrando relações sobre as orientações teórico-metodológicas/ideológicas em suas percepções acerca da atividade pedagógica nas intervenções realizadas.
Workshop Manajemen Pemanfaatan Vegetasi Untuk Mendukung Pengelolaan Lingkungan Lestari Untuk Produk Ecoprint
Authors: Slamet Bejo , Risnasari Iwan , Samsuri Samsuri , Zaitunah Anita , Muhdi Muhdi , Anggraini Novita , Latifah Siti , Syahputra O K Hasnanda , Purwoko Agus , Affandi Oding , Rahmawaty Rahmawaty 
Published: November 2022

Dusun 6 Desa Sei Glugur Kecamatan Pancurbatu Kabupaten Deliserdang mempunyai Kelompok Pembinaan Kesejahteraan Keluarga (PKK) yang anggotanya mempunyai keahlian menjahit namun variasi produk kain yang dipergunakan masih terbatas. Sumberdaya alam terutama vegetasi di lingkungan desa sangat banyak dijumpai. Berdasarkan kondisi ini maka perlu adanya Edukasi Dan Workshop Manajemen Pemanfatan Vegetasi Untuk Mendukung Pengelolaan Lingkungan Lestari Menjadi Produk Ecoprint. Pengabdian dilaksanakan pada tanggal 28 November 2020 bertempat di Dusun 6 Desa Sei Glugur Kecamatan Pancurbatu Kabupaten Deliserdang. Pengabdian secara umum dibagi menjadi dua sesi yaitu penanaman pohon buah-buahan yang bisa dimanfaatkan bagian tanamannya untuk ecoprint dan workshop ecoprint. Bibit tanaman yang ditanam berfungsi untuk menunjang ketersediaan bahan pewarna alami dan menghasilkan buah serta mampu menjaga kelestarian lingkungan. Jenis tanaman buah yang disukai oleh masyarakat setempat adalah alpukat, manggis dan duren. Workshop ecoprint ini mempraktekkan tiga metode pada kain dan satu pada kertas. Hasil dari pengabdian ini tampak pada perubahan pengetahuan dan keterampilan ibu-ibu PKK dalam memanfaatkan bagian tanaman untuk produk ecoprint baik pada kain maupun kertas. Perlu ada workshop pemasaran untuk memasarkan hasil-hasil produk ecoprint yang akan dikerjakan oleh ibu-ibu PKK selepas workshop ini.
Capturing Consumer Preferences to Develop the New Product Development of Ordinary Kids Through The Co-Creation Process
Authors: Nur Fajari Sihabudin , Mirzanti Isti Raafaldini 
Published: November 2022

The e-commerce fashion industry is rapidly evolving. As the seasons change, consumer preferences shift according to context. As recorded during the COVID-19 outbreak, many significant changes in style, behavior, and habits are either for adults or children. Hence, to capture this change, businesses must collaborate with their customers in developing products to avoid failure and meet positive perceptions. A qualitative methodology was used as an approach. Primary data come from interviews, documentation, and question boxes with purposive sampling. Secondary data includes articles, books, journals, and technical documents. The analysis for this study finds the main results for the next new product development by co-creation process. First, there are main preferences that must be put on children's clothing such as soft fabric, adorable, fashionable, and fit size; second, the author developed an integrative collaboration involving external and internal participation, and engagement as requisites for five co-creation processes (co-ideation, co-evaluation, co-design, co-test, and co-launch) in product development; third, participant in this study give a positive response to the product in accordance with ideation proposal and inputs.
Workplace Social Support in Coronatime as a Moderator Between Leader–Subordinate Fit and Entrepreneurial Behaviour
Authors: Ahmed Jinan Shihab 
Published: November 2022

this study investigated the moderating effect of workplace social support on the relationship between leader–subordinate fit and entrepreneurial behaviour in an Iraqi private higher education institution. A sample of 127 respondents was selected and a questionnaire was administered to them via Google Form. The data thus collected were analysed using JASP. Consistent with the P-E fit theory, the results revealed that supplementary fit (β = 0.44, t = 6.65, p .001, 95%CI = 0.29 to 0.53) and complementary fit (β = 0.46, t = 6.91, p .001, 95%CI = 0.31 to 0.56) significantly predicted entrepreneurial behaviours. However, in contradiction to the buffering hypothesis, the semi-partial Bayes Factor (BF) statistics indicate that workplace social support did not play any moderating role in the model. The study concludes with a brief discussion on the results, limitations of the study, and suggestions for further research.
Exogenous Putrescine Enhances Rice Seed Germination in Salinity Stress
Authors: Sabur Md. Abdus , Haque Md. Anwarul , Islam Md. Shahidul , Khan Muhammad Angkan , Faruquee Hossain Md. , Islam Md Azizul 
Published: November 2022

Putrescine plays a distinct role in various types of biological functions in all living organisms, as well as environmental stress. The aim of the study is to effect of exogenous putrescine on the physiological condition of the rice seeds investigated. Salt treatment resulted in the reduction of speed of germination, germination, germination energy, germination energy percentage, final germination percentage, shoot and root length, and plant dry weight, where proline content was remarkably increased. Among the rice varieties, BRRI 48 was affected maximum by way of salinity in case of germination and growth, and GHORIAL become least affected in comparison to other varieties. However, exogenous putrescine treatment significantly enhances rice seeds germination, as well as shoot and root length in all varieties. Our findings reveal that plant putrescine tremendously reduced rice salt tolerance.
Effects of Health Behaviors on Triglyceride/High Density Lipoprotein Cholesterol Ratio in Korean Adults
Authors: Boo Kyunghyun , Lee Yong Hwan 
Published: November 2022

Triglyceride (TG)/high density lipoprotein cholesterol (HDL-C) ratio is significantly related to insulin resistance. This study aimed to assess the impact of health behaviors on the TG/HDL-C ratio in Korean adults. This was a cross-sectional study using data from 16,722 subjects (7,328 men and 9,394 women) aged over 20 years of the 7th (2016-2018) Korean National Health and Nutrition Examination Survey (KNHANES). Effects of health behaviors on TG/HDL-C was determined by comparing TG/HDL-C after combining different health behaviors. In male subjects, TG/HDL-C ratio was high if they did not perform aerobic physical activity while smoking or drinking alcohol (p < 0.05). Their TG/HDL-C ratio was also high when smoking and drinking at the same time even if aerobic physical activity was performed (p < 0.05). In female subjects, all TG/HDL-C ratios were high if they did not perform aerobic physical activity except when they were drinking alcohol (p < 0.05). In Koreans, to lower the TG/HDL-C ratio, regular aerobic physical activity is necessary. For males, smoking cessation and abstinence should be done at the same time to lower the TG/HDL-C ratio
AKHLAKUL KARIMAH SEBAGAI PEMODERASI FAKTOR-FAKTOR PENENTU PERILAKU KEPATUHAN WAJIB PAJAK
Authors: Yusdin Yusdin , Bulutoding Lince , Suhartono Suhartono 
Published: November 2022

Penelitian ini bertujuan untuk menguji pengaruh pemahaman peraturan perpajakan, kualitas pelayanan fiskus dan penegakan hukum pajak terhadap perilaku kepatuhan wajib pajak dengan akhlakul karimah sebagai variabel moderasi (studi pada wajib pajak muslim orang pribadi yang terdaftar di KPP Pratama Kolaka). Penelitian ini merupakan penelitian kuantitatif . Populasi dalam penelitian ini adalah wajib pajak muslim orang pribadi yang terdaftar di KPP Pratama Kolaka. Sampel dalam penelitian ini berjumlah 140 wajib pajak muslim orang pribadi. Data yang digunakan merupakan data primer. Analisis data menggunakan analisis regresi berganda dan Analisis regresi moderating dengan pendekatan nilai selisih mutlak. Hasil penelitian menunjukan bahwa pemahaman peraturan perpajakan, kualitas pelayanan pajak dan penegakan hukum pajak berpengaruh positif signifikan terhadap perilaku kepatuhan wajib pajak. Analisis variabel moderasi dengan pendekatan nilai selisih mutlak menujukan bahwa akhlakul karimah tidak dapat memoderasi pemahaman peraturan perpajakan, kualitas pelayanan pajak dan akhlakul karimah dapat memoderasi penegakan hukum terhadap perilaku kepatuhan wajib pajak muslim orang pribadi
Pengaruh Akuntabilitas, Transparansi dan Fairness Terhadap Kinerja Instansi Pemerintah dengan Pemanfaatan Accounting Information System Sebagai Pemoderasi
Authors: Arifin Wahyuni Uni , Muchlis Saiful , Suhartono Suhartono 
Published: November 2022

Penelitian ini bertujuan untuk menguji pengaruh akuntabilitas, transparansi, dan fairness terhadap kinerja instansi pemerintah dengan pemanfaatan accounting system sebagai variabel moderating. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan deskriptif. Populasi dalam penelitian ini adalah seluruh pegawai yang bekerja di BPKAD Provinsi Sulawesi Selatan. Teknik pengambilan sampel menggunakan metode purposive sampling. Sampel di dalam penelitian ini adalah pegawai yang bekerja pada BPKAD Provinsi Sulawesi Selatan dengan ketentuan bahwa responden yang bersangkutan minimal telah bekerja selama satu tahun pada BPKAD Provinsi Sulawesi Selatan tersebut, adapun sampel dalam penelitian ini berjumlah 50 pegawai. Hasil penelitian menunjukkan bahwa akuntabilitas, transparansi, dan fairness berpengaruh positif terhadap kinerja instansi pemerintah. Analisis variabel moderating dengan pendekatan uji interaksil menunjukkan bahwa pemanfaatan accounting system mampu memoderasi hipotesis akuntabilitas dan transparansi terhadap kinerja instansi pemerintah, namun pemanfaatan accounting system tidak memoderasi fairness terhadap kinerja instansi pemerintah.
GREEN ACCOUNTING: REFLEKSI HAK ASASI MANUSIA DALAM UPAYA PENCEGAHAN LIMBAH
Authors: Auliya Nuril , Abdullah M. Wahyuddin , Suhartono Suhartono 
Published: November 2022

ABSTRAK: This study aims to determine green accounting as an innovation in waste prevention efforts, and the application of green accounting in reflecting on human rights. Qualitative research uses an approachphenomenology with the analysis unit of PT Kawasan Industri Makassar in South Sulawesi. Data collection was carried out by interviewing techniques and other secondary data support. The results showed that PT Kawasan Industri Makassar participates in preserving the environment, namely making waste management efforts by paying attention to the quality standards and fairness of waste determined by the government before being disposed of into the environment, and solid waste by reducing the use of paper which is replaced by a (paperless) system. The Waste Water Treatment Plant (WWTP) is a waste management installation that is the center for the collection of all waste in the area, the WWTP can prevent and reduce waste, and the company incurs environmental conservation costs by making a special report, but the environmental cost reporting is not grouped according to category, resulting in stakeholders having difficulty in identifying environmental costs. So the company has not fully implemented green accounting.Keywords: Green Accounting, Human Rights, Waste PreventionABSTRAK: Penelitian ini bertujuan untuk mengetahui green accounting sebagai inovasi dalam upaya pencegahan limbah, dan penerapan green accounting dalam merefleksi hak asasi manusia. Penelitian kualitatif menggunakan pendekatan fenomenologi dengan unit analisis PT Kawasan Industri Makassar di Sulawesi Selatan. Pengumpulan data dilakukan dengan teknik wawancara dan dukungan data sekunder lainnya. Hasil penelitian menunjukan bahwa PT Kawasan Industri Makassar berpartisipasi dalam menjaga kelestarian lingkungan, yaitu melakukan upaya pengelolaan limbah dengan memperhatikan baku mutu dan kewajaran limbah yang ditentukan pemerintah sebelum di buang ke lingkungan, dan limbah padat dengan mengurangi penggunaan kertas yang diganti dengan sistem (paperless). Waste Water Treatment Plant (WWTP) merupakan instalansi pengelolaan limbah yang menjadi pusat berkumpulnya seluruh limbah yang ada di kawasan, adanya WWTP dapat mencegah dan mengurangi limbah, dan perusahaan mengeluarkan biaya konservasi lingkungan dengan membuat laporan khusus, namun pelaporan biaya lingkungan tersebut tidak di kelompokkan berdasarkan kategori, mengakibatkan stakeholder mengalami kesulitan dalam mengidentifikasi biaya lingkungan. Jadi perseroan belum sepenuhnya menerapkan green accounting, dan belum bisa memenuhi ekspetasi masyarakat terkait dampak lingkungan dari aktivitas perusahaan mengenai kepeduliannya akan hak warga sekitar kawasan, tetapi hak asasi manusia bisa menjadi tolak ukur dalam penerapan akuntansi lingkungan dalam upaya pencegahan limbah, karena HAM membahas hak-hak masyarakat untuk memperoleh lingkungan yang bersih.Kata Kunci: Green Accounting, Hak Asasi Manusia, Pencegahan Limbah