bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex difference in patients with controlled acromegaly—A multicentre survey
Authors: Dal Jakob , Rosendal Christian , Karmisholt Jesper , Feldt‐Rasmussen Ulla , Andersen Marianne S. , Klose Marianne , feltoft Claus , Heck Ansgar , Nielsen Eigil H. , Jørgensen Jens O. L. 
Published: April 2022

AbstractObjectiveActive acromegaly is subject to sex differences in growth hormone (GH) and Insulin like growth factor 1 (IGF‐I) patterns as well as clinical features but whether this also pertains to controlled disease is unclear.DesignIn a cross‐sectional, multi‐centre study, 84 patients with acromegaly (F = 43, M = 41), who were considered controlled after surgery alone (n = 23) or during continued somatostatin receptor ligand (SRL) treatment (n = 61), were examined.MethodsSerum concentrations of GH, insulin, glucose and free fatty acid (FFA) were measured during an oral glucose tolerance test (OGTT) together with baseline serum IGF‐I and completion of two HR‐Qol questionnaires (acromegaly quality of life questionnaire [AcroQol] and Patient‐assessed Acromegaly Symptom Questionnaire [PASQ]).ResultsThe mean age at the time of the study was 57 (±1.1) years and the majority of females (were postmenopausal. Females had significantly higher fasting GH but comparable IGF‐I standard deviation scores (SDS). Using fasting GH < 1.0 µg/L as cut off, disease control was less prevalent in females (F: 56% vs. M: 83%, p = .007) whereas a comparable figure was observed using IGF‐I SDS < 2 (F:79% vs. M:76%, p = .71). Compared with males, female patients showed impaired AcroQol physical score (p = .05), higher fasting FFA (p = .03) and insulin concentrations during the OGTT (p = .04).ConclusionIn patients with acromegaly considered controlled, postmenopausal females exhibited higher GH levels than males despite comparable IGF‐I levels, which also translated into impaired metabolic health and well‐being. Our findings point to the relevance of including GH measurements in the assessment of disease control and suggest that disease‐specific sex differences prevail after treatment.
Character strengths as a link between family psychosocial environment and depression symptoms among Chinese adolescents
Authors: Liu Qianwen , Wang Ning , Wang Zhenhong 
Published: April 2022

AbstractThe present study examined how perceived interparental conflict and parental attachment combined with character strengths contributed to depression symptoms among Chinese adolescents. A total of 978 adolescents (Mage = 13.71 years, SD = 0.57; 470 girls) completed a battery of questionnaires. The results indicated that adolescents' perceived interparental conflict could directly affect adolescents' depression symptoms and indirectly via parental attachment. More importantly, parental attachment and global character strengths, particularly teamwork and spirit and faith, played serial multiple mediating roles in the relationship between perceived interparental conflict and adolescents' depression symptoms. Our findings provided strengths‐based perspectives to promote adolescents' mental health.
Upgrading in the Automotive Periphery: Turkey's Battery Electric Vehicle Maker Togg
Authors: Mordue Greig , Sener Erman 
Published: April 2022

ABSTRACTRestructuring of the automotive industry in the post‐2000 period has led to the emergence of three strata of automotive manufacturing jurisdictions. Core automotive countries host the headquarters of global automakers. They retain most research and development (R&D) and high levels of production. By contrast, integrated peripheries offer low‐cost labour. While increasing levels of vehicle production have gravitated there, they have been unable to attract mandates for knowledge‐intensive portions of the automotive value chain. Finally, semi‐peripheries have neither a home‐grown automaker nor low‐cost labour. Consequently, they have been unable to gain mandates for R&D and struggle to maintain production. Thus, policy makers in non‐core countries consider a range of tools to either retain their position or ‘graduate’ from one category to another. Recently, the demand for battery electric vehicles (BEVs) has given rise to new vehicle manufacturers. Turkey is attempting to develop a BEV automaker and jump from an automotive integrated periphery country to one having a key attribute of an automotive core: a home‐grown automaker. This article reveals and discusses Turkey's generous incentives and assesses the challenges the Turkish BEV entrant will confront, as well as its potential to generate wider economic benefits. The authors also consider the application the Turkey case study has for our understanding of power and upgrading in automotive global value chains.
An ever more critical dialogue: Table‐talking with Paulo Freire on education and liberation
Authors: Brondos David A. 
Published: April 2022

AbstractThis past year marked the centenary of the birth of Brazilian educator Paulo Freire (1921–1997). Like Martin Luther, Freire saw literacy, critical reflection, and dialogue among those oppressed by systems that exploited and excluded them as the primary means toward their liberation. As we seek to address systemic injustice and oppression today, we can learn a great deal by looking to the pedagogical thought of Freire and Luther and placing them in critical dialogue with one another and with our own contexts.
Building bridges across borders: An integrative literature review of project work and careers
Authors: Jemine Grégory , Stuer David , Sulbout Jérôme 
Published: April 2022

AbstractProject‐based forms of work have been steadily increasing in all sorts of organizations, which has led scholars to investigate their effects on career development and career management practices. However, disciplinary and conceptual divides have prevented comprehensive conceptualizations of project workers' careers to emerge to this day. Building on an integrative literature review, the paper underlines the predominance of individual‐centred research designs giving pride of place to project managers, at the expense of organizational‐centred studies accounting for the multiple stakeholders involved in project workers' careers. Five research perspectives on project work and careers are highlighted: Project work may be studied under the prism of career management, career transitions, career orientations, career advantages, and role transitions. The review is concluded with a comprehensive framework articulating project work and careers. The paper ultimately pleads for further investigation of project work and careers from a multistakeholder and organizational perspective.
Value of genetic testing for pediatric epilepsy: Driving earlier diagnosis of ceroid lipofuscinosis type 2 Batten disease
Authors: Leal‐Pardinas Fernanda , Truty Rebecca , McKnight Dianalee A. , Johnson Britt , Morales Ana , Bristow Sara L. , Yar Pang Tiffany , Cohen‐Pfeffer Jessica , Izzo Emanuela , Sankar Raman , Koh Sookyong , Wirrell Elaine C. , Millichap John J. , Aradhya Swaroop 
Published: April 2022

AbstractThis study assessed the effectiveness of genetic testing in shortening the time to diagnosis of late infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease. Individuals who received epilepsy gene panel testing through Behind the Seizure®, a sponsored genetic testing program (Cohort A), were compared to children outside of the sponsored testing program during the same period (Cohort B). Two cohorts were analyzed: children aged ≥24 to ≤60 months with unprovoked seizure onset at ≥24 months between December 2016 and January 2020 (Cohort 1) and children aged 0 to ≤60 months at time of testing with unprovoked seizure onset at any age between February 2019 and January 2020 (Cohort 2). The diagnostic yield in Cohort 1A (n = 1814) was 8.4% (n = 153). The TPP1 diagnostic yield within Cohort 1A was 2.9‐fold higher compared to Cohort 1B (1.0%, n = 18/1814 vs. .35%, n = 8/2303; p = .0157). The average time from first symptom to CLN2 disease diagnosis was significantly shorter than previously reported (9.8 vs. 22.7 months, p < .001). These findings indicate that facilitated access to early epilepsy gene panel testing helps to increase diagnostic yield for CLN2 disease and shortens the time to diagnosis, enabling earlier intervention.
Nest defense, personality, and fitness of a locally endangered island passerine
Authors: Suckow Nicole M. , Pollock Henry S. , Hauber Mark E. , Kastner Martin , Savidge Julie A. , Baker Kayla , Rogers Haldre S. 
Published: April 2022

AbstractPersonality, or repeatable variation in behavior, may impact an animal's survival or reproduction. Parental aggression is one such personality trait with potentially direct implications for fitness, as it can improve offspring survival during vulnerable early life stages. We took advantage of a long‐term nest box and fledgling survival monitoring project to explore the potential fitness consequences of both repeatability and variation in parental aggression in breeding pairs of a locally endangered passerine species (Såli: Micronesian starling, Aplonis opaca) in the presence of an invasive predator, the brown treesnake (Boiga irregularis), on the island of Guam. To do so, we tested for associations between aggressive offspring defense throughout the nesting cycle and three fitness measures: hatching success, fledging success, and post‐fledging survival. Aggression varied greatly among breeding pairs and was repeatable within pairs (R = .47), providing evidence of a personality trait. Consistent with parental investment theory, nest stage was the best predictor of parental aggression, which increased with offspring age. Aggression was positively correlated with hatching success during the egg stage, but not nestling or post‐fledging survival. We propose that parental aggression was decoupled from nestling and fledgling survival because parents were unable to defend young from nocturnal, invasive brown treesnakes. More broadly, our findings demonstrate that repeatable variation in personality traits may not necessarily confer fitness benefits, particularly in the presence of invasive predators.
‘I Don't Like Uncertainty, I Like to Know’: How and why uveal melanoma patients consent to life expectancy prognostication
Authors: Brown Stephen L. , Fisher Peter L. , Morgan Andrew , Davies Cari , Olabi Yasmin , Hope‐Stone Laura , Heimann Heinrich , Hussain Rumana , Cherry Mary Gemma 
Published: April 2022

AbstractBackgroundTechnological advances have led to cancer prognostication that is increasingly accurate but often unalterable. However, a reliable prognosis of limited life expectancy can cause psychological distress. People should carefully consider offers of prognostication, but little is known about how and why they decide on prognostication. Using uveal melanoma (UM) patients, we aimed to identify (i) how and why do people with UM decide to accept prognostication and (ii) alignment and divergence of their decision‐making from conceptualizations of a ‘well‐considered’ decision.MethodsUM provides a paradigm to elucidate clinical and ethical perspectives on prognostication, because prognostication is reliable but prognoses are largely nonameliorable. We used qualitative methods to examine how and why 20 UM people with UM chose prognostication. We compared findings to a template of ‘well‐considered’ decision‐making, where ‘well‐considered’ decisions involve consideration of all likely outcomes.ResultsParticipants wanted prognostication to reduce future worry about uncertain life expectancy. They spontaneously spoke of hoping for a good prognosis when making their decisions, but largely did not consider the 50% possibility of a poor prognosis. When pressed, they argued that a poor outcome at least brings certainty.ConclusionsWhile respecting decisions as valid expressions of participants' wishes, we are concerned that they did not explicitly consider the realistic possibility of a poor outcome and how this would affect them. Thus, it is difficult to see their decisions as ‘well‐considered’. We propose that nondirective preference exploration techniques could help people to consider the possibility of a poor outcome.Patient or Public ContributionThis paper is a direct response to a patient‐identified and defined problem that arose in therapeutic and conversational discourse. The research was informed by the responses of patient participants, as we used the material from interviews to dynamically shape the interview guide. Thus, participants' ideas drove the analysis and shaped the interviews to come.
Exploring the knowledge base of trauma and trauma informed care of staff working in community residential accommodation for adults with an intellectual disability
Authors: McNally Paddy , Irvine Mandy , Taggart Laurence , Shevlin Mark , Keesler John 
Published: April 2022

AbstractBackgroundTaking a trauma informed care approach has demonstrated positive outcomes for services for people in the general population. Given the increased vulnerability to psychological trauma for adults with an intellectual disability, this study explores what residential staff know about trauma and trauma informed care.MethodsThirty‐two staffs representing three staff groups: direct care staff; managers; and specialist practitioners, were interviewed using semi‐structured interviews, which were analysed following a structured framework.FindingsEach staff group held different perspectives in their knowledge of trauma and trauma informed care. Limitations were noted in staffs' knowledge of trauma, implementation of evidence‐based supports, and access to specialist services for adults with an intellectual disability. All participants highlighted their training needs regarding trauma.ConclusionIncreased training on recognising and responding to trauma is needed among community staff supporting those with a trauma history if organisations are to move towards trauma informed care.
Grasses through space and time: An overview of the biogeographical and macroevolutionary history of Poaceae
Authors: Gallaher Timothy J. , Peterson Paul M. , Soreng Robert J. , Zuloaga Fernando O. , Li De‐Zhu , Clark Lynn G. , Tyrrell Christopher D. , Welker Cassiano A.D. , Kellogg Elizabeth A. , Teisher Jordan K. 
Published: April 2022

AbstractGrasses are widespread on every continent and are found in all terrestrial biomes. The dominance and spread of grasses and grassland ecosystems have led to significant changes in Earth′s climate, geochemistry, and biodiversity. The abundance of DNA sequence data, particularly chloroplast sequences, and advances in placing grass fossils within the family allows for a reappraisal of the family′s origins, timing, and geographic spread and the factors that have promoted diversification. We reconstructed a time‐calibrated grass phylogeny and inferred ancestral areas using chloroplast DNA sequences from nearly 90% of extant grass genera. With a few notable exceptions, the phylogeny is well resolved to the subtribal level. The family began to diversify in the Early–Late Cretaceous (crown age of 98.54 Ma) on West Gondwana before the complete split between Africa and South America. Vicariance from the splitting of Gondwana may be responsible for the initial divergence in the family. However, Africa clearly served as the center of origin for much of the early diversification of the family. With this phylogenetic, temporal, and spatial framework, we review the evolution and biogeography of the family with the aim to facilitate the testing of biogeographical hypotheses about its origins, evolutionary tempo, and diversification. The current classification of the family is discussed with an extensive review of the extant diversity and distribution of species, molecular and morphological evidence supporting the current classification scheme, and the evidence informing our understanding of the biogeographical history of the family.
Down‐phase auditory stimulation is not able to counteract pharmacologically or physiologically increased sleep depth in traumatic brain injury rats
Authors: Moreira Carlos G. , Hofmann Pascal , Müllner Adrian , Baumann Christian R. , Ginde Varun R. , Kollarik Sedef , Morawska Marta M. , Noain Daniela 
Published: April 2022

SummaryModulation of slow‐wave activity, either via pharmacological sleep induction by administering sodium oxybate or sleep restriction followed by a strong dissipation of sleep pressure, has been associated with preserved posttraumatic cognition and reduced diffuse axonal injury in traumatic brain injury rats. Although these classical strategies provided promising preclinical results, they lacked the specificity and/or translatability needed to move forward into clinical applications. Therefore, we recently developed and implemented a rodent auditory stimulation method that is a scalable, less invasive and clinically meaningful approach to modulate slow‐wave activity by targeting a particular phase of slow waves. Here, we assessed the feasibility of down‐phase targeted auditory stimulation of slow waves and evaluated its comparative modulatory strength in relation to the previously employed slow‐wave activity modulators in our rat model of traumatic brain injury. Our results indicate that, in spite of effectively reducing slow‐wave activity in both healthy and traumatic brain injury rats via down‐phase targeted stimulation, this method was not sufficiently strong to counteract the boost in slow‐wave activity associated with classical modulators, nor to alter concomitant posttraumatic outcomes. Therefore, the usefulness and effectiveness of auditory stimulation as potential standalone therapeutic strategy in the context of traumatic brain injury warrants further exploration.
‘No other alternative than to compromise’: Experiences of midwives/nurses providing care in the context of scarce resources
Authors: Boakye Priscilla N. 
Published: April 2022

AbstractMidwives and nurses play a critical role in safeguarding the lives of women in resource‐constrained African countries. Working within the context of scarce resources may undermine their moral agency and hinder their ability to care. The purpose of this paper is to understand the influence of resource scarcity on midwifery and nursing care and practice. A critical ethnography was conducted in the obstetric department of three tertiary‐level facilities in Ghana. Purposive sampling was used to recruit 30 midwives and nurses and semistructured interviews, field notes and documentary materials were used to generate in‐depth understanding. Ethical approval was granted from Canada and Ghana and written, and ongoing informed consent was obtained from the participants. Five conceptual themes depicting the impact of scarce resources on midwifery and nursing care were discovered: compromised care, constrained care, dehumanized care, missed care and disengaged care. Improving the maternal health of women and averting avoidable maternal morbidity and mortality require governments and institutions to invest in health infrastructure that will support the delivery of ethical and safe midwifery care for women in their most vulnerable period.
Global scientific production, international cooperation, and knowledge evolution of public administration
Authors: Lyu Peng‐Hui , Zhang Ming‐Ze , Liu Chuan‐Jun , Ngai Eric W. T. 
Published: April 2022

AbstractPublic administration is a discipline with considerable history, and is also a diverse, interdisciplinary field in social science. To analyze its evolution, discover the present research foci, and predict future development trends, this study applied scientometrics visualization technology to evaluate over 72,000 scientific articles from the 1920s to 2020s. This research referred to the SSCI and JCR databases to gather scientific data of the discipline and the journals' impact factor. Consequently, paper citations, cited journals, journal co‐citations, author co‐citations, authoritative papers, top countries, productive institutes, average references, and research collaboration trends were analyzed on the bases of the published literature. This study found top productive journals in the discipline, discovered productive countries and institutes, present the research foci, and predicted future development trends. Through this study, scientific production, international cooperation, and knowledge evolution mode of public administration research offers a clear knowledge map of the public administration discipline.
Grain carbon isotope composition is a marker for allocation and harvest index in wheat
Authors: Domergue Jean‐Baptiste , Abadie Cyril , Lalande Julie , Deswarte Jean‐Charles , Ober Eric , Laurent Valérie , Zimmerli Céline , Lerebour Philippe , Duchalais Laure , Bédard Camille , Derory Jérémy , Moittie Thierry , Lamothe‐Sibold Marlène , Beauchêne Katia , Limami Anis M. , Tcherkez Guillaume 
Published: April 2022

AbstractThe natural 13C abundance (δ13C) in plant leaves has been used for decades with great success in agronomy to monitor water‐use efficiency and select modern cultivars adapted to dry conditions. However, in wheat, it is also important to find genotypes with high carbon allocation to spikes and grains, and thus with a high harvest index (HI) and/or low carbon losses via respiration. Finding isotope‐based markers of carbon partitioning to grains would be extremely useful since isotope analyses are inexpensive and can be performed routinely at high throughput. Here, we took the advantage of a set of field trials made of more than 600 plots with several wheat cultivars and measured agronomic parameters as well as δ13C values in leaves and grains. We find a linear relationship between the apparent isotope discrimination between leaves and grain (denoted as Δδcorr), and the respiration use efficiency‐to‐HI ratio. It means that overall, efficient carbon allocation to grains is associated with a small isotopic difference between leaves and grains. This effect is explained by postphotosynthetic isotope fractionations, and we show that this can be modelled by equations describing the carbon isotope composition in grains along the wheat growth cycle. Our results show that 13C natural abundance in grains could be useful to find genotypes with better carbon allocation properties and assist current wheat breeding technologies.
Determinants of attrition between Waves 1 and 2 of South Africa's National Income Dynamics Study – Coronavirus Rapid Mobile Survey (NIDS‐CRAM)
Authors: Daniels Reza Che , Ingle Kim P. , Brophy Timothy S. L. 
Published: April 2022

AbstractWe introduce a new approach to the analysis of attrition in South African longitudinal surveys by supplementing the public‐use data with paradata about the survey process and interview experience. The number of successfully interviewed respondents reduced from 7,073 in Wave 1 of NIDS‐CRAM to 5,676 in Wave 2—a level of attrition of almost 20%. We fit probit regression models to predict the determinants of attrition. In the fully specified model, attrition was most affected by contact effort by the survey organisation, the sample batch the respondent was in during Wave 1, employment status and whether they had a missing value for household income. Another important finding was that respondents who underwent COVID‐19 tests were 3% more likely to attrite, a trend that could negatively affect the efficacy of the survey to track COVID‐19 testing behaviour in future waves. Attrition was not influenced by how often respondents previously participated or refused in NIDS, the interviewer‐interviewee experience in the interview or by the respondent's observable demographic characteristics. This is a new contribution to the South African literature on attrition and shows the importance of using paradata to understand nonresponse.