bluuebunny/crossref_metadata_2025_split huggingface dataset:
AICAR activates AMPK to regulate STAT3 nuclear translocation and phosphorylation and iNOS expression in inflammatory pain
Authors: Xiang Hongchun , Cai Guo-Wei , Hu Liang , Zhu He , Lin Lixue , Liu Yongmin , Hu Xuefei , Chen Chao , Yuan Xiaocui , Weng Tao , Zou Yan , Pan Huilin , Liu Wentao , Li Man 
Published: May 2022

Abstract
AMP-activated protein kinase (AMPK) activators can improve inflammatory pain and neuropathic pain. Inflammation translocate signal transducers and activators of transcription 3 (STAT3) to the nuclei of activated macrophages, and STAT3 phosphorylation promotes the expression of inducible nitric oxide synthetase (iNOS). We determined whether AMPK activation alleviate inflammatory pain via STAT3 nuclear translocation and phosphorylation. In this study, immunoblotting was used to measure the expression of p-AMPK, and iNOS. Immunoblotting and immunofluorescence were used to detect the nuclear translocation of p-STAT3(Ser727) and STAT3 in macrophages of local inflammatory tissues. Flow cytometry was used to measure reactive oxygen species (ROS) accumulation and mitochondrial damage. AMPK activation with AICAR significantly alleviated pain hypersensitivity and inhibited the expression of iNOS in complete Freund's adjust (CFA)-induced inflamed skin tissues. CFA caused nuclear translocation of STAT3 and p-STAT3(Ser727) in macrophages of inflamed skin tissues. AICAR inhibited nuclear translocation of STAT3 and p-STAT3(Ser727) and promoted the phosphorylation of STAT3(Ser727) in the cytoplasm of macrophages. AICAR also inhibited the expression of iNOS and nuclear translocation of STAT3 and p-STAT3(Ser727), and promoted the phosphorylation of STAT3(Ser727) in NR8383 macrophages treated with CFA. AMPK activation also inhibited the ROS generation and the mitochondrial damage of NR8383 macrophages caused by CFA. In addition, transfection of STAT3 S727D decreased ROS and alleviated mitochondrial damage. In conclusion, Activation of AMPK attenuates inflammatory pain and suppresses STAT3 nuclear translocation and phosphorylation of STAT3(Ser727) in macrophages, resulting in reduced iNOS. Activation of AMPK also promotes phosphorylation of STAT3(Ser727) in the cytoplasm of macrophages to alleviate ROS accumulation and mitochondrial damage associated with inflammation.
The possibility of using anti-human monoclonal antibody CD3 as pan T-cell marker in guinea pigs
Authors: Popko Svitlana , Aksamytieva Mariya 
Published: May 2022

The present study was aimed to evaluate the possibility of using anti-human monoclonal antibody CD3 as pan T-cell marker in the guinea pigs’ trachea and lung in early and late manifestations of the allergic inflammatory process.
Materials and methods.We have studied the distribution and quantitative changes of CD3-positive lymphocytes in trachea and lung of guinea pigs using histological, immunohistochemical, statistical methods in conditions of experimental inflammatory process.
Results. Our results revealed the applicability of anti-Human monoclonal antibody CD3 (Clone SP7, «DAKO», Denmark) cross-reaction with T-cells of guinea pigs’ tracheas and lungs. The most statistically significant elevation of the number of CD3-positive lymphocytes, in comparison with the control group (p*/**<0.05), observed in the experimental group III in the late stages of experimental inflammatory process. The elevation of the number of CD3-positive lymphocytes persists even after the termination of the allergen action, which indicates the continuation of the reaction of pulmonary local adaptive immunity to the allergen.
Conclusions. The results of our study may be useful in conditions of the deficiency of guinea pig-specific tests. The immunohistochemical assessment of guinea pigs’ trachea and lungs proved the possibility to use anti-Human monoclonal antibody CD3 as a panT-cell marker in guinea pigs. We demonstrated the activation of adaptive immune response (T-cells), represented by their immunohistochemical changes, predominantly in the late stages of experimental inflammatory process.
Morphometric measurements of calcaneum in North Indian population
Authors: Ghalawat Neeru , Sharma Jitender , Singh Surinder , Malik Vivek Singh 
Published: May 2022

Calcaneum is the largest tarsal bone in the foot, which participate in the formation of subtalar joint.
Aims and objectives The difference in the anatomical structure of calcaneum plays an important role in dynamic, kinetic, and static of the foot. Hence this study was planned.
Material and methods. Present study was conducted in Pt. B. D. Sharma University of health sciences on 54 pair of dry human calcanei in which linear measurements were taken using digital vernier caliper with accuracy of 0.01mm and Bohler’s angle (BA) was measured with goniometer. Correlation of Bohler’s angle and maximum antero-posterior length (MXL) with another parameter were seen.
Results. In present study no significant difference was seen in the measurements of right and the left calcanei. Correlation of MXL of calcaneum with other parameters was done which came out to be significant except for CFH (right side) and DAFW (right side). Presented findings suggest that the MXL of the calcaneum bone can sometimes be calculated from its other parameters if well preserved, which could be helpful for forensic experts.
Conclusion. Present study on morphometric parameters of calcaneum would provide useful information for orthopaedic surgeries. Also, the knowledge of morphometry of this bone would be useful for forensic experts, foot rehabilitation procedure, and this study would contribute to the anatomic literature and clinical fields.
Đánh giá khả năng loại bỏ methylene blue của vật liệu hấp phụ được điều chế từ mụn dừa bằng phương pháp Hummers cải tiến
Authors: Lương Huỳnh Vủ Thanh , Cao Lưu Ngọc Hạnh , Đặng Huỳnh Giao , Trần Thị Bích Quyên , Lê Thị Ngọc Dung , Phạm Thị Hồng Quyên 
Published: May 2022

Nghiên cứu được thực hiện nhằm đánh giá khả năng loại bỏ thuốc nhuộm methylene blue trong nước bằng vật liệu hấp phụ (VLHP) từ mụn dừa được chế tạo bằng phương pháp Hummers cải tiến. Các yếu tố ảnh hưởng đến quá trình tổng hợp vật liệu được tiến hành khảo sát nhằm tìm ra các điều kiện tối ưu. VLHP từ mụn dừa được phân tích hóa lý bằng phân tích nhiệt trọng lượng, diện tích bề mặt riêng. Diện tích bề mặt riêng của vật liệu là 9,3 m2/g và đường kính mao quản của VLHP là 6,96 nm. Hiệu suất hấp phụ đạt 99,82± 0,10% ở nồng độ đầu của MB là 500 mg/L và pH 8 tại nhiệt độ 30℃ trong vòng 40 phút đã cho thấy VLHP có khả năng xử lý chất màu MB rất tốt. Quá trình hấp phụ tuân theo mô hình đẳng nhiệt hấp phụ Langmuir ở khoảng nồng độ từ 10-50 mg/L, trong khi mô hình hấp phụ đẳng nhiệt Freundlich lại phù hợp với khoảng nồng độ MB ban đầu 50-500 mg/L.
Biologic initiation rates in systemic-naive psoriasis patients after first-line apremilast versus methotrexate use
Authors: Kaplan David , Husni Elaine , Chang Eunice , Broder Michael S , Paydar Caleb , Bognar Kata , Yan Jessie , Richter Sven , Desai Pooja , Khilfeh Ibrahim 
Published: May 2022

Aim:
To compare rates of biologic initiation after commencing treatment with apremilast (APR) versus methotrexate (MTX) in systemic-naive patients with psoriasis (PsO).
Methods:
This was a retrospective cohort study of systemic-naive patients with PsO who initiated treatment with APR or MTX between 1 January 2015 and 31 March 2018.
Outcomes:
Adjusted rates of biologic initiation during follow-up were compared by logistic and Cox regressions.
Results:
APR initiators had 58% lower likelihood of biologic initiation (odds ratio: 0.42; 95% CI: 0.37–0.48; p < 0.001), lower adjusted biologic initiation rate (14.4% [95% CI: 13.2–15.7%] vs 28.6% [95% CI: 26.8–30.5%]), lower risk of biologic initiation (hazard ratio: 0.45; 95% CI: 0.40–0.51; p < 0.001) compared with MTX initiators.
Conclusion:
Systemic-naive patients with PsO have a lower rate of biologic initiation over 1 year following APR initiation.
Economic burden of drug overdose deaths before and during the COVID-19 pandemic in the USA
Authors: Lui Briana , White Robert S , Aaronson Jaime , Hoyler Marguerite 
Published: May 2022

Aim:
To evaluate the impact of the COVID-19 pandemic on the economic burden of drug overdose deaths in the USA.
Methods:
Overdose death counts from 2019 to 2020 were obtained from the CDC's National Vital Statistics System. Years of potential life lost and value of statistical life were computed.
Results:
The financial burden of overdose deaths increased by nearly 30%, from US$624.90 billion before the pandemic in 2019 to US$825.31 billion during the pandemic in 2020. Temporal analysis demonstrated that overdose deaths peaked in the second quarter of 2020 and contributed to nearly a third of the total 2020 value of statistical life.
Conclusion:
The authors' findings suggest that the COVID-19 pandemic has exacerbated the US drug overdose epidemic.
Developing Material for Teaching Paragraph Writing Using Technological Pedagogical and Content Knowledge (TPACK)
Authors: Farikah Farikah 
Published: May 2022

This design based research was aimed to to develop materials for teaching paragraph writing using TPACK approach. The students of English Department of Tidar University (Untidar) were involved as the subject of the reserach. This research was conducted in four phases. They were analysis of practical problems, development of solutions, iterative cycles of testing and refinement of solution, and reflection to produce design and principles. The results of the research indicated that technological pedagogical and content knowledge approach material was needed for teaching paragraph writing. These findings recommended this TPACK approach-based material could be adopted as materials for teaching paragraph writing.
The Changing of Students' Language and Behaviour by the Intensity of Intercultural Communication on Social Media: A Case Study in ELT Class
Authors: Supriadin Supriadin , Umar Umar 
Published: May 2022

This research conducted based on the phenomon on the languages and behaviours are showed by the students when they interact with their friends, teachers, and stafs at school. This research aims to find out the changes of students’ language and behavior in relation with the intensity of intercultural communication using social media. This research had been done in one of Senior High Schools in Mataram especially to the third grade students of science and social department. In getting the data, this research applied observation, interview, and questionnaire. It found that the intensity of exchange culture information by using social media has influenced most teenager today. Firstly, the students tend to use their language by using a kind of “Alay language” when they interact with their friends or even with their teachers whether inside or outside of the classroom. Secondly, the intensity of exchange culture information by using social media could help students to finish their school tasks. They work cooperatively with their friends in small groups. They are able to find out the information they need to present cultural celebrations and how something happens in less than fifteen minutes. This intercultural communication could also help them to build up their awareness of cultural differences among them. However, this intensive exchange of cultural information could also lead students to prefer to communicate with their network friends to friends in their school and home environment. Moreover, the students are likely becoming less sensitive towards their friends’ problems. In addition, the intensive of exchange of culture information by using social media could lead them to the model of thinking which is likely to force their arrogances and egoism.
Students' Perception of Listening Materials at University
Authors: Siradjuddin Suharti , Yahrif Muhammad 
Published: May 2022

The aims of this study are to assess students’ perception of listening materials used in the listening class of the English education program at the Megarezky University of Makassar. Students' perception of the use of listening materials is beneficial in order to understand and improve listening material especially in the English education program at the Megarezky University of Makassar. This researcher was used a qualitative approach to collect data through questionnaires and interviews. The participants of this research were 10 students of the English education program in the 2020/2021 academic year. The technique of analysis covers students' perception related to the general perception of listening material that they received in the first and second semester in listening courses. The finding indicated students have positive opinions of the listening materials used in class. However, there were some positive feedbacks and some potential problems with the use of listening materials. All these perceptions of the listening materials can imply the improvement of better listening materials in the future.
Students' Understanding of Plagiarism in Academic Writing: Indonesian Context
Authors: Tangkelangi Nuur Insan , Suardi Suardi , Upa' Rahmawati 
Published: May 2022

Extensive studies identify plagiarism as a grave problem in Indonesian university students’ academic writing (Adiningrum, 2015; Sulaiman, 2015; Zalnur, 2012).Plagiarism is the most severe problem found in students’ theses in the context investigated in this study (Tangkelangi & Widyasari, 2015).However, no study explicitly examines the extent that students understand plagiarism, including both its concept and its practices in the focused context. Therefore, this study aims to fill this gap by investigating students’ understanding of plagiarism. Considering the results of previous studies related to the potential factors involved in students’ understanding of plagiarism, this study also aims to determine whether gender and academic achievement are considerable factors in students’ plagiarism understanding in the focused context. To investigate these issues, survey research using an adapted questionnaire was conducted to gather data from seventy participants out of a total population of eighty-five students, who voluntarily participated in this study. The participants were third-year students majoring in English Education who will take a unit discussing plagiarism issues in the next semester. The data gathered from the participants was analysed using the Rasch model to determine the students’ understanding of plagiarism. Then, a t-test of two independent samples was used to examine whether the students’ understanding differed between gender and a Pearson’s rtest was used to examine whether academic achievement correlated with their plagiarism understanding. The results of the analyses revealed that the students had a basic understanding of plagiarism and their understanding did not differ between gender or with academic achievement. These findings imply that several plagiarism principles need to be explored more, including unattributed paraphrasing, self-plagiarism and citations and referencing. It is also implied that special treatment for a particular gender or a certain academic achiever is not necessary.
Clinical outcome of horses with guttural pouch infection following transpharyngeal fenestration
Authors: Koch Drew W. , Ericksen Kelsea A. , Easley Jeremiah T. , Hackett Eileen S. 
Published: May 2022

Abstract

OBJECTIVE
To report the clinical outcomes of horses with chronic guttural pouch infection characterized by accumulation of mucopurulent material following transpharyngeal diode laser fenestration.

ANIMALS
13 client-owned horses

PROCEDURES
Horses undergoing diode laser fenestration for chronic guttural pouch infection were identified by medical record search. Signalment, disease history, presence of mucopurulent empyema or chondroids, and pre- and postoperative therapy were recorded. Owners were contacted for follow-up information at a minimum of 6 months following surgery.

RESULTS
13 horses underwent laser fenestration for chronic guttural pouch infection. Thirteen had mucopurulent nasal discharge on presentation, and 3 were coughing. At follow-up, 12 horses treated with transpharyngeal diode laser fenestration had complete resolution of nasal discharge and coughing. One horse, despite resolution of guttural pouch infection on endoscopy, continued to have nasal discharge and coughing attributed to concurrent equine asthma syndrome. All owners expressed satisfaction with the surgical procedure and clinical resolution of guttural pouch infection.

CLINICAL RELEVANCE
This surgical technique for transpharyngeal diode laser fenestration of the guttural pouch was uncomplicated to perform and well tolerated in sedated horses and attributed to resolution of clinical signs associated with guttural pouch infection, and owners reported a high satisfaction with the clinical outcome. Implementing this surgical technique could be considered to hasten resolution of chronic guttural pouch disease in horses with few technique-related complications.
Does Tribulus terrestris L. affect hormonal responses following high-intensity resistance exercise?
Authors: Ardakani Seyed Mojtaba Paydar , Pokrywka Andrzej , Ghuzhdi Hamideh Dinari , Roozbeh Behnam , Rahmati Siavash , Abdolmohamadi Ali 
Published: May 2022

Abstract

Study aim: To investigate the effect of a 2-week supplementation with Tribulus terrestris L. (TT) on the responses of testosterone, cortisol, and thyroid hormones including triiodothyronine (T3) and thyroxine (T4) following an intensive session of resistance exercise (RE).

Materials and methods: Twenty-two healthy non-athlete men (23.8 ± 3.1 years) participated in this study were divided into two groups and were randomly assigned to receive either TT supplementation (n = 11) or a placebo (n = 11). They consumed two 250-mg capsules with TT or placebo (maltodextrin) per day and performed six REs with the intensity 80-90% of 1RM on the fifteen day of the experiment. Venous blood samples were drawn before supplementation, and before and after the RE session.

Results: The mean values of post-exercise testosterone and cortisol in both groups were significantly higher than pre-exercise and baseline (p < 0.01); however, there were no significant differences between the groups (p > 0.05). Likewise, despite a trend toward different levels of the responses of thyroid hormones with TT supplementation, there were no significant differences either in different time points or the groups (p > 0.05).

Conclusions: Short-term supplementation with TT appears to be ineffective in changing the hormonal responses measured in this study following a session of high-intensity RE.
Inventory management in food retail in Serbia
Authors: Lukic Radojko 
Published: May 2022

Abstract
In this paper, the determinants (return gross margin on inventory, return gross margin on sales, inventory turnover ratio, firm size, capital intensity) of inventory management efficiency in Serbian trade are investigated. An econometric approach is used. The research established that the key factors in the efficiency of inventory management in Serbian trade are: return gross margin on sales (gross margin/sales) and inventory turnover ratio (sales/inventories). Their effective control can achieve the target profit of food retailers in Serbia.
Current Situation with the Sensory Quality of Gluten-Free Bakery Products from the Czech Market Network
Authors: Tauferová Alexandra , Jirsová Eliška 
Published: May 2022

Abstract
A large number of gluten-free baking mixes for making homemade bakery products can be found on the market, in addition to ready-made products – both unpacked and packed. The main objective of this study was to examine the current situation regarding the sensory quality of commercially available gluten-free bakery products on the Czech market. In total, 16 samples were analysed both individually and within groups of unpacked bakery products, packed bakery products, and bakery products made in a technological laboratory using baking mixes. Both a quantitative descriptive analysis and hedonic test of gluten-free bakery products were performed by 18 trained panellists, consisting of academic staff and students of University of Veterinary Sciences Brno, Czech Republic. The results were statistically evaluated by means of principal component analysis. A close correlation between descriptors of surface colour, saltiness, and overall pleasantness of the sample was established. Descriptors of surface colour (1.36–5.75), saltiness (1.22–4.12), sweetness (1.78–5.08), and yeastiness (1.93–4.52) showed the highest degree of variability in the evaluation of individual samples. Statistically highly significant differences were observed between the individual groups of samples of gluten-free bakery products. Based on hedonic testing, the group comprising samples of unpacked bakery products was evaluated as the best; in contrast, the group comprising packed bakery products was evaluated as the worst. The group comprising samples baked from purchased baking mixes was characterized by statistically significantly lower pleasantness of appearance and taste.
A case of a giant thoracic schwannoma
Authors: Saleemi Mohammad Saleem , Abdelwahab Ahmed Ossama Yassin , Abdelwahab Muhammad Ossama Yassin , George K. Joshi 
Published: May 2022

Background:
Giant solitary schwannomas are rare, benign, and typically slow-growing tumors reaching up to 20 cm in size.

Case Description:
A 43-year-old male presented with shortness of breath and chest pain. The thoracic MRI showed a giant mass 15 cm in diameter filling the left chest cavity. The lesion was resected utilizing intrathoracic approach and required a multilevel approach. Vertebrectomy with instrumented fusion was performed. The pathological diagnosis was benign schwannoma without nuclear atypia. Postoperatively, the patient fully recovered without sequelae.

Conclusion:
A 43-year-old male presented with a 15 cm diameter chest mass that proved to be a schwannoma that was resected without long-term sequelae.
Intracranial venous reflux without the central venous occlusive disease in a patient receiving hemodialysis through brachio-brachial arteriovenous fistula: A case report
Authors: Ito Sayaka , Taniguchi Masanobu , Uemura Yuki , Higuchi Kazushi 
Published: May 2022

Background:
Upper-limb arteriovenous fistula as a hemodialysis access among patients with end-stage renal disease (ESRD) has become a preferred type of vascular access. However, complications involving the central nervous system may occur. There have been no reported cases of internal jugular vein (IJV) regurgitation without central venous occlusive diseases (CVODs).We describe the case of a patient on HD who presented with symptomatic IJV regurgitation without CVODs.

Case Description:
An 83-year-old man with ESRD receiving HD through a left upper-limb AVF presented with impaired consciousness and seizures. After recovery from unconsciousness, he became alert with cognitive impairment. The left subclavian arteriography revealed early filling of the left subclavian vein due to the AVF on the left brachium, with retrograde high-flow venous reflux to the left IJV, sigmoid and transverse sinuses, with the left central veins patent. All cerebral venous drainage procedures were dependent on the right IJV. The left internal carotid arteriography showed venous congestion of the left hemisphere. The flow of the left brachial artery was measured extremely high. Under compression of the left brachial artery to reduce the flow, the regurgitation persisted. With the findings that all cerebral venous return were in the right IJV, sacrificing the left IJV was thought to be acceptable. Left IJV ligation was performed, and the patient’s cognitive function improved.

Conclusion:
The short-term outcome after IJV ligation may be positive in the patient who was confirmed to have a normal cerebral venous return route independent of the refluxed IJV.