bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regenerative Medicine-Based Treatment of Stress Urinary Incontinence
with Mesenchymal Stem Cells: A Systematic Review and Meta-analysis
Authors: Mariotti Gianna , Salciccia Stefano , Viscuso Pietro , Bevilacqua Giulio , Casale Paolo , Frisenda Marco , Di Pierro Giovanni Battista , Cattarino Susanna , Gentilucci Alessandro , Rosati Davide , Sciarra Beatrice , Sciarra Alessandro 
Published: June 2022

Objectives:
The aim of this systematic review and meta-analysis is to analyze clinical trials on the use of autologous stem cell [SC] injection for the treatment of stress urinary incontinence [SUI] in humans.

Methods:
We analyzed the effect in terms of UI improvement and continence recovery after treatment. A literature search was performed following the PRISMA guidelines. Entry into the analysis was restricted to data collected from clinical prospective trials on humans, including female and male patients with SUI. We performed a cumulative meta-analysis to explore the trend in the effect size across different groups at follow-up. Available data were compared in terms of Event Rate [ER] for the percentage of pad-free patients.

Results:
12 trials were enclosed in the analysis. Sample size of patients with SUI ranged from 5 to 123 cases, mainly female cases. Autologous muscle-derived [MDSC] were used in 9 and adipocyte-derived SC [ADSC] in 3 trials. Considering a random effect model, ER of continence recovery was 0.41 [95%CI 0.29 - 0.54], with similar results between the ADSC [ER, 0.40;95%CI 0.12 – 0.69] and the MDSC group [ER 0.41; 95%CI 0.27-0.55] [I2 84.69%; Q 104.69 - p<0.01] [Test of group differences p=0.96]

Conclusions:
Autologous MDSC or ADSC injection to treat SUI demonstrated to be a safe procedure and a 41% mean rate of continence recovery is described. A higher effort should be produced to design better clinical trials, objectively evaluating either modifications inside the urethral sphincter or long-term functional results in terms of pad test and UI questionnaires.
Correlation of Pericoronal Radiolucency Around Impacted Mandibular Third Molars Using CBCT with Histopathological Diagnosis: A Prospective Study
Authors: Ahmed Junaid , Nath Mandovi , Sujir Nanditha , Ongole Ravikiran , Shenoy Nandita 
Published: June 2022

Purpose:
This study aimed to correlate the pericoronal width surrounding impacted mandibular third molars with their histopathological findings.

Materials and Methods:
The present study included patients who were advised for extraction of impacted mandibular third molars with the pericoronal radiolucency radiographically. The CBCT scans were compared with histopathologic findings of the follicles.

Results:
Out of 70 patients evaluated histopathologically, 24 patients showed mild inflammatory changes, whereas 34 patients revealed cystic changes suggestive of a dentigerous cyst, followed by 12 patients showing evidence of calcifications in the pericoronal follicles. The dentigerous cyst was more likely to occur if the bucco-lingual width of the pericoronal radiolucency was 14.00-16.00mm, and calcifications were found to be most likely present if the buccolingual width was 12.00-14.00mm, both of which were statistically significant.

Conclusion:
CBCT can be a reliable tool in the evaluation of pericoronal follicular space, and the values in different dimensions can be an accurate predictor radiologically for the diagnosis of pathologies when compared to 2D imaging.
The Contemporary Management of Cleft Lip and Palate and the Role of Artificial Intelligence: A Review
Authors: Marya Anand , Venugopal Adith , Karobari Mohmed Isaqali , Chaudhari Prabhat Kumar , Heboyan Artak , Rokaya Dinesh 
Published: June 2022

Introduction:
Cleft management is an exhaustive process for the patient, the orthodontist, and the caregiver. In recent decades, a wide number of challenges have been addressed with the inclusion of various dental specialties for the detection, diagnosis, and treatment of orofacial clefts. The orthodontist plays a very pivotal role during the overall management of children with cleft lip and palate as they need to make critical decisions for when to intervene orthodontically and at what stage to set priorities for individual treatment goals.

Objectives:
The objectives of this study were to provide an in-depth review of the evolving role of various disciplines focusing on orthodontics in the management of cleft cases.

Methods:
A general search was carried out to identify the published data on cleft lip and cleft palate management on PubMed and Scopus until the 1st of June 2021 using keywords such as cleft lip, cleft palate, cleft orthodontics, naso-alveolar molding, and surgical cleft orthodontics. The related literature was then reviewed and analyzed.

Results:
With improvements in 3D modeling, CT scans of patients can be used to construct precise 3D models, and these can be utilized to demonstrate various clinical issues related to clefts. The orthodontist has a major role in the various stages and steps, follow-up, treatment care, and outcome assessment. With the advent of technological advancements and artificial intelligence, the role is only going to evolve and expand further in the management of the cleft lip and palate. Diagnostic techniques utilizing artificial intelligence to detect cleft during the prenatal period have also been tested and have been shown to have a high rate of accuracy. The evolution of distraction osteogenesis came into the limelight as a revolutionary modality for cleft treatment. Computer-assisted orthognathic surgery is a widely used modality for reshaping the osseous defects of the maxilla in patients with congenital clefts. With the development of additional modalities such as aligners, patients that need to undergo complex orthognathic surgeries can also be treated with aligners without compromising the outcomes.

Conclusion:
The cleft lip and palate can be managed by a multi-disciplinary team. Orthodontics has an important role in the overall management of a cleft affected individual as they must make critical decisions regarding orthodontic interventions as well as set priorities for each treatment goal. With the advent of technological advancements and artificial intelligence, the diagnosis and management of the cleft lip and palate have become simplified.
Nephrotic Syndrome and Renin-angiotensin System: Pathophysiological
Role and Therapeutic Potential
Authors: Silva Ana Cristina Simões E. , dos Anjos Alessandra Aguiar , de Paiva Isadora Tucci , Simões Lima Giovanna Letícia , da Silva Filha Roberta , Fróes Brunna Pinto E. , Brant Pinheiro Sérgio Veloso 
Published: June 2022

Abstract:
Idiopathic Nephrotic Syndrome (INS) is the most frequent etiology of glomerulopathy
in pediatric patients and one of the most common causes of chronic kidney disease (CKD) and
end-stage renal disease (ESRD) in this population. In this review, we aimed to summarize evidence
on the pathophysiological role and therapeutic potential of the Renin-Angiotensin System
(RAS) molecules for the control of proteinuria and for delaying the onset of CKD in patients
with INS. This is a narrative review in which the databases PubMed, Web of Science, and Sci-
ELO were searched for articles about INS and RAS. We selected articles that evaluated the pathophysiological
role of RAS and the effects of the alternative RAS axis as a potential therapy for
INS. Several studies using rodent models of nephropathies showed that the treatment with activators
of the Angiotensin-Converting Enzyme 2 (ACE2) and with Mas receptor agonists reduces
proteinuria and improves kidney tissue damage. Another recent paper showed that the reduction
of urinary ACE2 levels in children with INS correlates with proteinuria and higher concentrations
of inflammatory cytokines, although data with pediatric patients are still limited. The molecules
of the alternative RAS axis comprise a wide spectrum, not yet fully explored, of potential
pharmacological targets for kidney diseases. The effects of ACE2 activators and receptor Mas
agonists show promising results that can be useful for nephropathies including INS.
An Analysis of Different Distance-Linkage Methods for Clustering Gene Expression Data and Observing Pleiotropy: Empirical Study
Authors: Choudhury Joydhriti , Ashraf Faisal Bin 
Published: June 2022

Background
Large amounts of biological data have been generated over the last few decades, encouraging scientists to look for connections between genes that cause various diseases. Clustering illustrates such a relationship between numerous species and genes. Finding an appropriate distance-linkage metric to construct clusters from diverse biological data sets has thus become critical. Pleiotropy is also important for a gene’s expression to vary and create varied consequences in living things. Finding the pleiotropy of genes responsible for various diseases has become a major research challenge.

Objective
Our goal was to establish the optimal distance-linkage strategy for creating reliable clusters from diverse data sets and identifying the common genes that cause various tumors to observe genes with pleiotropic effect.

Methods
We considered 4 linking methods—single, complete, average, and ward—and 3 distance metrics—Euclidean, maximum, and Manhattan distance. For assessing the quality of different sets of clusters, we used a fitness function that combines silhouette width and within-cluster distance.

Results
According to our findings, the maximum distance measure produces the highest-quality clusters. Moreover, for medium data set, the average linkage method, and for large data set, the ward linkage method works best. The outcome is not improved by using ensemble clustering. We also discovered genes that cause 3 different cancers and used gene enrichment to confirm our findings.

Conclusions
Accuracy is crucial in clustering, and we investigated the accuracy of numerous clustering techniques in our research. Other studies may aid related works if the data set is similar to ours.
Impacts of Digital Care Programs for Musculoskeletal Conditions on Depression and Work Productivity: Longitudinal Cohort Study
Authors: Costa Fabíola , Janela Dora , Molinos Maria , Moulder Robert , Bento Vírgilio , Lains Jorge , Scheer Justin , Yanamadala Vijay , Cohen Steven , Dias Correia Fernando 
Published: June 2022

Background
Comorbidity between musculoskeletal (MSK) pain and depression is highly common, and is associated with a greater symptom burden and greater loss of work productivity than either condition alone. Multimodal care programs tackling both physical and mental health components may maximize productivity recovery and return to work. Digital delivery of such programs can facilitate access, ensure continuity of care, and enhance patient engagement.

Objective
The aim of this study was to assess the impact of a completely remote multimodal digital care program (DCP) for MSK pain on mental health and work-related outcomes stratified by baseline depression levels.

Methods
Ad hoc analysis of an interventional, single-arm, cohort study of individuals with MSK pain undergoing a DCP was performed. Three subgroups with different baseline depression severity levels were established based on responses to the Patient Health Questionnaire (PHQ-9): cluster 1 (score<5: minimal depression), cluster 2 (scores 5-10: mild depression), and cluster 3 (score≥10: moderate depression). The mean changes in depression, anxiety, fear-avoidance beliefs, work productivity, and activity impairment and adherence between baseline and end of program (8-12 weeks) were assessed across subgroups by latent growth curve analysis.

Results
From a total of 7785 eligible participants, 6137 (78.83%) were included in cluster 1, 1158 (14.87%) in cluster 2, and 490 (6.29%) in cluster 3. Significant improvements in depression and anxiety scores were observed in clusters 2 and 3 but not in cluster 1, with average end-of-the program scores in clusters 2 and 3 below the initially defined cluster thresholds (score of 5 and 10, respectively). All clusters reported significant improvements in productivity impairment scores (mean changes from –16.82, 95% CI –20.32 to –13.42 in cluster 1 to –20.10, 95% CI –32.64 to –7.57 in cluster 3). Higher adherence was associated with higher improvements in depression in clusters 2 and 3, and with greater recovery in activities of daily living in cluster 3. Overall patient satisfaction was 8.59/10.0 (SD 1.74).

Conclusions
A multimodal DCP was able to promote improvements in productivity impairment scores comparable to those previously reported in the literature, even in participants with comorbid depression and anxiety. These results reinforce the need to follow a biopsychosocial framework to optimize outcomes in patients with MSK pain.

Trial Registration
ClinicalTrials.gov NCT04092946; https://clinicaltrials.gov/ct2/show/NCT04092946
Acute effects of resistance exercise with blood flow restriction on cardiovascular response: a meta-analysis
Authors: Lemos Leonardo Kesrouani , Toledo Teixeira Filho Carlos Alberto , Biral Taíse Mendes , de Souza Cavina Allysiê Priscilla , Junior Eduardo Pizzo , Oliveira Damasceno Silas de , Vanderlei Franciele Marques 
Published: June 2022

Aim:
To compare the acute effects of low-load resistance training associated with blood flow restriction (LLRT-BFR) with low-load resistance training (LLRT) and high-load resistance training (HLRT) on cardiovascular outcomes in healthy individuals.
Methods:
This review was registered and the studies were selected using seven databases. Randomized controlled clinical trials were included that evaluated LLRT-BFR compared with LLRT and HLRT in young individuals for the cardiovascular outcomes.
Results:
19 studies were included. In the comparison of LLRT-BFR with HLRT, there were significant differences for cardiac output and heart rate – with reduced values and in favor of LLRT-BFR.
Conclusion:
There are no greater acute effects of the addition of blood flow restriction, with the exception of the reduction in cardiac output and heart rate for LLRT-BFR compared with HLRT.
Prednisone and deflazacort in Duchenne muscular dystrophy: a patient perspective and plain language summary publication of the Cincinnati study
Authors: Wong Brenda L , Cook Tiffany , Miller Hawken 
Published: June 2022

What is this summary about?
This is a summary of an article about the Cincinnati study, which was published in the Journal of Comparative Effectiveness Research in January 2020. The Cincinnati study reviewed data from 435 males with Duchenne muscular dystrophy, also known as DMD, who were treated at the Cincinnati Children's Hospital Medical Center. DMD is a rare disease that worsens over time. People with DMD experience inflammation in their muscles and muscle loss over time. They also experience bone problems such as an abnormally bent spine, also known as scoliosis, as well as heart and lung problems.

What happened in the Cincinnati study?
Prednisone and deflazacort are steroids that help to reduce muscle inflammation and are used as treatments for DMD. The study researchers wanted to further understand the differences between using prednisone and deflazacort in males with DMD by reviewing data from past medical records of patients seen in clinics rather than in clinical studies. This is known as gathering real-world evidence. In the Cincinnati study, the researchers compared males with DMD who started taking prednisone as their first steroid treatment with males who started taking deflazacort as their first steroid treatment.

What were the results?
Overall, the researchers found that the participants who took deflazacort were able to walk until a later age before they needed to use a wheelchair, compared with those who took prednisone. They also had a lower risk of scoliosis and developed it at a later age.

What do the results of the study mean?
These results helped the researchers to learn more about the differences between how well prednisone and deflazacort work in males with DMD based on their medical records.
Hubungan Antar Agama menurut Al-Quran dan Hadis
Authors: Marzatillah Marzatillah , Wahid Abd. 
Published: June 2022

Sensitive issues that occur today are the relationship between religions that are not harmonious, the birth of Islamophobia among non-Muslims has given birth to a negative stigma against Islam, this is due to their misunderstanding of the teachings of Islam. This condition has resulted in disharmony in the social life of the community and even the emergence of hostility. This paper seeks to clarify the misunderstanding of non-Muslims toward Islam by explaining the concept of tolerance in the Qur'an and the Sunnah of the Prophet. The results of the study show that in terms of humanity, Islam is very tolerant and upholds human values, while in matters of religious belief, Islam provides limits so that it does not fall into shirk because it is a big sin that is not forgiven by Allah swt. Isu sensitif yang terjadi saat ini adalah hubungan antar agama yang tidak harmonis, lahirnya islamophopia di kalangan non muslim telah melahirkan stigma negatif terhadap Islam, hal diakibatkan kesalah pahaman mereka terhadap ajaran Islam. kondisi ini telah mengakibatkan terjadinya disharmonis dalam kehidupan sosial masyarakat bahkan munculnya permusuhan. Tulisan ini berupaya memperjelas kesalah pahaman kalangan non muslim terhadap Islam dengan menjelaskan konsep toleransi dalam Alquran dan Sunnah Rasul. Hasil penelitian menunjukkan bahwa dalam hal kemanusian, Islam sangat toleran dan menjunjung tinggi nilai-nilai kemanusian, sedangkan dalam persoalan keyakinan beragama, Islam memberi batasan agar agar tudak terjerumus dalam kesyirikan, karena hal itu merupakan dosa besar yang tidak diampunkan oleh Allah swt.
Problems of ESG-Reorganization of Russian Metallurgical Corporations
Authors: Tsygalov Yu. M. 
Published: June 2022

The development of environmental programs in modern conditions is characterized by the ESG transformation of the economy. In the EU, which is the most important importer of Russian steel products, a new carbon tax will be levied from 2025–2026, which will increase the costs of domestic producers by more than 20%. The peculiarity of the new tax is that it applies to the industry value chain, including suppliers and consumers of metal, which jeopardizes other sectors of the national economy.The purpose of the study is to identify the problems and risks generated by the transition of Russian ferrous metallurgy companies to ESG principles of management. The object of research is ESG transformation of the economy. The subject of the study is the problems and risks of the Russian ferrous metallurgy formed by the ESG transformation. General scientific methods were used, such as: analysis, synthesis, abstraction, modeling, generalization. It is established that the ESG transformation of the economy makes the restructuring of Russian metallurgical companies inevitable. At the same time, domestic companies lag behind Western ones in the development of technologies that lead to a zero carbon footprint. Inefficient work to reduce the carbon footprint leads to the payment of carbon tax on foreign markets, fines on the domestic market, prevents the receipt of “green” financing. Starting from 2026, the financial condition of metallurgical companies will rapidly deteriorate. The implementation of the Targeted (intensive) development scenario provided for by the “Strategy of Socio-economic Development of the Russian Federation with low Greenhouse Gas Emissions until 2050” and the active support of the state will help to maintain the position in the markets.
Analysis of Trends in the Higher Education and Science as the Basis for Strategizing the Scientific and Innovative Activities in Regional Universities
Authors: Pahomova E. A. 
Published: June 2022

Aim of the article is to identify global, national and local trends in the development of higher education and science, which should be taken into account when strategizing the scientific and innovative activities of a regional university (in the conditions of the Kemerovo region — Kuzbass).Materials and methods. The methodological and theoretical basis of the study is the theory of strategy and the strategy methodology developed by V. L. Kvint (Moscow State University named after M. V. Lomonosov), which made it possible to substantiate the analysis of opportunities and threats as the initial stage of strategizing the scientific and innovative activities of a regional university. The methods of OTSW-analysis, economic-statistical analysis, comparative analysis were used Analytical and forecast documents of authoritative Russian and international organizations dealing with the problems of science and higher education were used.results. 12 trends of various levels are identified that determine the opportunities and threats for the strategic development of scientific and innovative activities in the universities of the Kemerovo region — Kuzbass. At the global level, these include a decrease in demand for higher education and the need for scientific and innovative diversification; the growth of the global research and development market, especially in certain niches; growth in the share of research and development funding by commercial organizations; influence on the research topics of the international agenda, including the UN sustainable development goals. The main national trends are instability and limited funding for research and development, the growing interest of the state in fundamental research; maintaining a low level of integration of universities with business with the growth of the innovative activity of the latter; the growing stratification of the domestic higher education. In the Kemerovo region — Kuzbass, the most important trends are the structural transformation of the traditional university system with increased competition among universities; limited demand for research and development, not corresponding to the economic importance of the region; creation of institutional foundations for the development of scientific and innovative activities and the strategic goals of Kuzbass for scientific and technological development, which determine promising areas of research.Conclusions. Based on the analysis of strategically significant trends, the first stage of the OTSW analysis was implemented, the opportunities and threats that determine the strategic development of research activities of the universities of the Kemerovo region — Kuzbass were identified.