bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bridging and downstaging with TACE in early and intermediate stage hepatocellular carcinoma: Predictors of receiving a liver transplant
Authors: Yin Chao , Armstrong Samantha , Shin Richard , Geng Xue , Wang Hongkun , Satoskar Rohit S. , Fishbein Thomas , Smith Coleman , Banovac Filip , Kim Alexander Y. , He Aiwu Ruth 
Published: November 2022

AbstractBackground and AimsIn patients with surgically unresectable early and intermediate stage hepatocellular carcinoma (HCC), only liver transplant (LT) offers a cure. Locoregional therapies, such as transarterial chemoembolization (TACE), are widely used to bridge patients waiting for an LT or downstage tumors beyond Milan Criteria (MC). However, there are no formal guidelines on the number of TACE procedures patients should receive. Our study explores the extent to which repeated TACE might offer diminishing gains toward LT.ApproachWe retrospectively analyzed 324 patients with BCLC stage A and B HCC who had received TACE with the intention of disease downstaging or bridging to LT. In addition to baseline demographics, we collected data on LT status, survival, and the number of TACE procedures. Overall survival (OS) rates were estimated using the Kaplan‐Meier method, and correlative studies were calculated using chi‐square or Fisher's exact test.ResultsOut of 324 patients, 126 (39%) received an LT, 32 (25%) of whom had responded favorably to TACE. LT significantly improved OS: HR 0.174 (0.094‐0.322, P < .001). However, the LT rate significantly decreased if patients received ≥3 vs < 3 TACE procedures (21.6% vs 48.6%, P < .001). If their cancer was beyond MC after the third TACE, the LT rate was 3.7%.ConclusionsAn increased number of TACE procedures may have diminishing returns in preparing patients for LT. Our study suggests that alternatives to LT, such as novel systemic therapies, should be considered for patients whose cancers are beyond MC after three TACE procedures.
Electrically‐assisted chemical vapor polymerization: A novel method for in situ polymerization of pyrrole
Authors: Shukla Ankur , Das Dipayan , Sen Kushal 
Published: November 2022

AbstractThis article offers a fast and innovative process for carrying out in situ polymerization of pyrrole onto a polyester fabric. This process is based on electrically‐assisted chemical vapor polymerization that takes around 180 s to produce an electroconductive fabric with a surface resistance of as low as 70 Ω. The ultrasonication carried out at 20 kHz frequency is quite effective in binding the polymer to the fabric. Fourier‐transform infrared spectroscopy and X‐ray diffraction studies confirm that the polymer formed is polypyrrole. The application of electric potential across an oxidant‐enriched fabric results in polymer add‐on of polypyrrole as high as 250%. The amount of polypyrrole formed and the surface resistance of the fabric are found to depend on the potential applied across the fabric. The concentrations of the oxidant and the dopant, the time of polymerization, and the rate of monomer vaporization are found to be critical in deciding the surface resistance of the fabric.
Detection of Indigo Carmine dye in juices via application of photoluminescent europium‐doped carbon dots from tannic acid
Authors: Albalawi Marzough Aziz , Gomaa Hassanien , El Hamd Mohamed A. , Abourehab Mohammed A. S. , Abdel‐Lateef Mohamed A. 
Published: November 2022

AbstractIndigo Carmine is a hazardous dye and produces an allergic action for humans despite the excessive use of the dye in several industrial fields. A sensitive and simple fluorescent assay for determining Indigo Carmine relying on quenching of the fluorescent europium‐doped carbon dots by the action of inner filter effect was developed. This sensing platform involved the preparation of europium‐doped carbon dots from the hydrothermal carbonization of tannic acid and europium chloride, which was used as fluorescent reagent with a distinctive excitation/emission wavelength at 307/340 nm. Both excitation and emission fluorescence of prepared carbon dots can be successfully quenched by adding Indigo Carmine dye. The developed spectrofluorimetric method exhibits good linearity with the concentration of Indigo Carmine dye in the range of 1.5 to 10.0 μg/ml and provided a limit of detection (LOD) value of 0.40 μg/ml. Furthermore, the prepared carbon nanoparticles were identified and characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier‐transform infrared (FTIR), and ultraviolet (UV)‐spectrophotometer techniques. In addition, the developed detecting approach was applied to determine Indigo Carmine in juice samples with acceptable recovery.
Immobilization of Arg‐Gly‐Asp peptides on silk fibroin via Gly‐Ala‐Gly‐Ala‐Gly‐Ser sequences
Authors: Hashimoto Tomoko , Nakamura Yuka , Kakinoki Sachiro , Sano Naoko , Kameda Tsunenori , Tamada Yasushi , Yamaoka Tetsuji , Kurosu Hiromichi 
Published: November 2022

AbstractA simple method by which the functional peptide of Gly‐Arg‐Gly‐Asp‐Ser (GRGDS) is immobilized on the surface of silk fibroin (SF) films via Gly‐Ala‐Gly‐Ala‐Gly‐Ser (GAGAGS) sequences is proposed. GAGAGS, a repeating amino acid sequence in the crystal region of Bombyx mori SF, performs a key role in interacting with and immobilizing SF molecules. Immobilization by this proposed method involves no chemical reaction, thereby preserving the original properties of the SF molecule. The density of GRGDS peptides existing on SF film was found to be higher in the GAGAGS‐bound type than in the non‐GAGAGS‐bound type. Furthermore, results showed that the amount of immobilized (GAGAGS)GRGDS peptide increased as the β‐sheet crystallization was promoted in the SF film. Fibroblasts, which adhered to the surface of the SF film, showed more extensibility because of the (GAGAGS)GRGDS immobilization, which suggests that the cell adhesion activity of RGD is functioning effectively.
The Effect of Different Drying Methods on Bioactive and Nutrition Contents of Bee Bread and Mathematical Modeling of Drying Characteristics
Authors: Kutlu Naciye , Gercek Yusuf Can , Bayram Nesrin Ecem 
Published: November 2022

AbstractIn this study, the aim was to determine the effect of different drying methods (with microwave and hot air) on the color, nutrient and bioactive contents of fresh bee bread. Drying characteristics were also investigated. Microwave and hot air drying were applied at different microwave powers and temperatures, respectively. Lower moisture ratios and highest effective diffusion coefficients were obtained with microwave drying in a shorter time. The Midilli model was found to be the most suitable thin‐layer drying model for both methods. Regardless of the drying conditions, moisture, ash, protein, carbohydrate, and lipid proportions were observed to vary in the ranges of 4.9–8.2 %, 1.61–2.67 %, 17.47–32.54 %, 39.92–60.84 %, and 7.10–8.89 %, respectively. The lowest color difference was obtained for the sample dried at 210 W. As a result, it was determined that microwave drying is more suitable for preserving the nutritional and bioactive content of bee bread during drying.
Synthesis of Novel 3‐Butylphthalide Derivatives Containing Isopentenylphenol Moiety as Potential Antiplatelet Agents for the Treatment of Ischemic Stroke
Authors: Yu Qinyang , Luo Bilan , Luo Zhongfu , Zhong Xu , Li Yi , Zhang Yi , Zhu Gaofeng , Guo Bing , Tang Lei , Li Yong , Fan Lingling 
Published: November 2022

AbstractIn order to find novel antiplatelet drugs for the treatment of ischemic stroke, a series of 3‐butylphthalide derivatives containing isopentenylphenol moiety were designed, synthesized and characterized with spectroscopic analyses. The in vitro antiplatelet activity results indicated that compound 3 better inhibited the arachidonic acid (AA) induced platelet aggregation than aspirin (ASP) and 3‐butylphthalide (NBP). Additionally, compared with precursor NBP, compound 3 possessed outstanding antithrombotic activity in the animal experiment model, which could effectively alleviate the formation of tail thrombus and carotid artery thrombus in mice. More importantly, intraperitoneal administration of compound 3 can well protected the rats against ischemia/reperfusion‐induced brain injury. Further pharmacokinetic (PK) assay indicated that compound 3 had good absorption characteristics and metabolic stability in vivo. Overall, the present research provides a new candidate compound for the treatment of ischemic stroke caused by platelet aggregation.
Preparation and Examination of a Composite Demulsifier for Paraffin Base Oil
Authors: Nadirova Zhanna , Zhantasov Manap , Bimbetova Gulmira , Nadirov Kazim , Ivachnenko Oleksandr , Otarbayev Nurlybek , Shukhanova Zhuldyz , Botashev Yersultan , Batyr Gulnaz 
Published: November 2022

AbstractThis study aimed to derive a new composite demulsifier for dehydration of highly emulgated oil with high paraffin content, reducing the emulsion stability. The main active substances are fatty acids of cotton steatite esterified with polyethylene glycol, as well as sulfanol, Sintanol ALM‐10, silica gel, and white spirit in certain proportions. Studies under laboratory conditions on the demulsification of oil from Ashysay field showed that the new composite demulsifier is a suitable reagent for the destruction of water‐oil emulsions. Sulfanol and Sintanol ALM‐10 confer washing and wetting effects on the mixture, and silica gel favors the adsorption of oil asphaltenes onto its surface.
Impact of matching field size on color matching (functions) accuracy
Authors: Li Jiaye , Hanselaer Peter , Smet Kevin A. G. 
Published: November 2022

AbstractAccurate colorimetry starts with accurate color matching functions (CMFs). Due to changes in the macular pigment and cone pigment optical densities at different retinal locations, different CMFs are required for different stimulus field sizes. To characterize the accuracy of the CIE recommendation for the use of 2° and 10° standard CMFs and the field‐size dependent CIEPO06 model, in this study, a series of achromatic matching experiments were performed with 2°, 4°, 6°, 8°, and 10° bipartite fields using spectrally narrowband primaries. Using the CIEPO06 model, optimal field sizes were estimated that minimize the chromaticity differences between the spectrally narrowband observer matches and the spectrally broadband achromatic target. It was found that the optimal field size estimated using the CIEPO06 model is close to half the actual bipartite field size in most cases, except for the 2° field. The discrepancy between the 10° bipartite field in Stiles & Burch's experiments and our optimal field size (6.54°) was assumed to be due to different individual color comparison strategies. However, the results of experiments requiring specific observer gaze positions did not support this assumption and the reason for the discrepancy remains unclear. Confirming our earlier results, the primary set (636, 521, 447 nm) was again found to be largely insensitive to changes in CMFs and to provide the most accurate matches under various fields of view. The inter‐ and intra‐observer variability ellipses for 2° matches are larger than those for 10°, consistent with Brown's finding for color discrimination ellipses. The magnitude of the intraobserver variability was similar for all field sizes, except for 2° field size, where matching errors were larger for some primary sets.
Evaluation of the impact of photoperiod and light intensity on decreasing days to maturity in winter wheat
Authors: Ficht Alexandra , Bruch Austin , Rajcan Istvan , Pozniak Curtis , Lyons Eric M. 
Published: November 2022

AbstractThe development and improvement of crop cultivars are necessary to meet the demands of the growing global population. The ability to decrease the generation time is imperative for breeders to achieve higher rates of genetic gain annually. Understanding the way in which photoperiod affects the maturation rate of these crops, including winter wheat (Triticum aestivum L.), is required for decreasing generation time in breeding programs. The effects of prolonged photoperiod and light intensity on winter wheat generation time were studied to determine if photoperiod may contribute to a shortened cycle time. Three winter wheat cultivars (Branson, CFBA1401, and Norstar) and one spring wheat cultivar (AC Carberry) were exposed to four treatments based on the daily light integral (DLI): high light (HL) or low light and photoperiod as follows: 22 h of light and 2 h of dark (22:2) or 16 h of light and 8 h of dark (16:8). Generation time, as measured by days to maturity in the HL22:2 treatment, resulted in a decrease of 8 days or 7% of the total generation time, compared to the control, HL16:8 treatment. Photoperiod itself had a minimal effect on generation time when both DLI and temperature were controlled. An improved understanding of the effects of photoperiod, thermal time, and DLI and their interactions is required prior to implementation in a winter cereal breeding program.
Plasma p‐tau181/Aβ1‐42 ratio predicts Aβ‐PET status and correlates with CSF‐p‐tau181/Aβ1‐42 and future cognitive decline
Authors: Fowler Christopher J. , Stoops Erik , Rainey‐Smith Stephanie R. , Vanmechelen Eugeen , Vanbrabant Jeroen , Dewit Nele , Mauroo Kimberley , Maruff Paul , Rowe Christopher C. , Fripp Jurgen , Li Qiao‐Xin , Bourgeat Pierrick , Collins Steven J. , Martins Ralph N. , Masters Colin L. , Doecke James D. 
Published: November 2022

AbstractBackgroundIn Alzheimer's disease (AD), plasma amyloid beta (Aβ)1‐42 and phosphorylated tau (p‐tau) predict high amyloid status from Aβ positron emission tomography (PET); however, the extent to which combination of these plasma assays can predict remains unknown.MethodsPrototype Simoa assays were used to measure plasma samples from participants who were either cognitively normal (CN) or had mild cognitive impairment (MCI)/AD in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study.ResultsThe p‐tau181/Aβ1‐42 ratio showed the best prediction of Aβ‐PET across all participants (area under the curve [AUC] = 0.905, 95% confidence interval [CI]: 0.86–0.95) and in CN (AUC = 0.873; 0.80–0.94), and symptomatic (AUC = 0.908; 0.82–1.00) adults. Plasma p‐tau181/Aβ1‐42 ratio correlated with cerebrospinal fluid (CSF) p‐tau181 (Elecsys, Spearman's ρ = 0.74, P < 0.0001) and predicted abnormal CSF Aβ (AUC = 0.816; 0.74–0.89). The p‐tau181/Aβ1‐42 ratio also predicted future rates of cognitive decline assessed by AIBL Preclinical Alzheimer Cognitive Composite or Clinical Dementia Rating Sum of Boxes (P < 0.0001).DiscussionPlasma p‐tau181/Aβ1‐42 ratio predicted both Aβ‐PET status and cognitive decline, demonstrating potential as both a diagnostic aid and as a screening and prognostic assay for preclinical AD trials.
A case of recurrent massive thickening of the gastric wall caused by pancreatitis of the gastric ectopic pancreas: Detailed pathogenesis based on imaging
Authors: Sasaki Shun , Ota Kazuhiro , Tanaka Ryo , Imai Yoshiro , Kojima Yuichi , Akutagawa Hiroshi , Iwatsubo Taro , Sugawara Noriaki , Hakoda Akitoshi , Tanaka Hironori , Mori Yosuke , Lee Sang‐Woong , Takeuchi Toshihisa , Nishikawa Hiroki 
Published: November 2022

AbstractA 40‐year‐old Japanese male presented with epigastric pain and loss of appetite at a general hospital three years ago. Computed tomography revealed massive thickening of the gastric wall, and gastroscopy revealed diffuse erythema and edematous thickening of the gastric mucosa. Thereafter, epigastric pain and gastric wall thickening recurred frequently, causing an inability to intake food. Conservative treatment was marginally effective; therefore, a distal gastrectomy was performed. Postoperatively, the patient resumed food intake without complications. Histopathological examination of the surgical specimen revealed Heinrich type 1 gastric ectopic pancreas (EP) with pancreatitis. In this case, the gastric wall's massive thickening was caused by gastric EP's pancreatitis. Although there are some reports of pancreatitis of gastric EP, there are no detailed reports of endoscopic findings, including endoscopic ultrasonography and the disease progression. Recurrent pancreatitis of EP leads to forming a septum within the gastric wall, resulting in a hematoma. Eventually, irreversible narrowing of the gastric lumen may occur, as observed in the present case. We consider this an important case report presenting detailed pathogenesis supported by endoscopic and pathohistological findings of surgical specimens. Our study will help in the early diagnosis and better management of the condition.
Catchment‐scale applications of hydraulic habitat models: Climate change effects on fish
Authors: Morel Maxime , Pella Hervé , Branger Flora , Sauquet Eric , Grenouillet Gaël , Côte Jessica , Braud Isabelle , Lamouroux Nicolas 
Published: November 2022

AbstractApproaches available for estimating the ecological impacts of climate change on aquatic communities in river networks range from detailed mechanistic models applicable locally to correlative approaches applicable globally. Among them, hydraulic habitat models (HABMs) link hydraulic models of streams with biological models that reflect how organisms select microhabitat hydraulics. Coarser but more general species distribution models (SDMs) predict changes in geographic distributions; they generally involve coarse predictors such as air temperature or distance to source but neglect proximate habitat descriptors such as microhabitat hydraulics. We propose an original application of HABM for predicting the ecological impacts of climate change at large scales, a comparison of their predictions with those of SDM and a linkage of the two modelling approaches. We showcase our approach in a large catchment (Rhône River) where an available distributed hydrological model estimates present and future unregulated daily flows over the whole river network. Despite large local uncertainties, simulations showed that climate change may strongly reduce low flow percentiles (e.g., a median reduction of 38.6% for a pessimistic climate scenario), inducing important alteration of fish hydraulic habitat suitability (e.g., a median loss of 3.9%–18.7% for three modelled fish species with contrasting habitat use: brown trout, barbel and sculpin). The HABM and SDM individually predicted consistent or opposite fish responses to climate change, depending on the species and their habitat requirements. Our results illustrate that accounting for ecological responses to proximate habitat variables such as hydraulics can strongly modify projections related to climate change.
One‐Pot Synthesis of Thiocarbamide Esters: Construction of C−S Bonds under Transition‐Metal‐Free Conditions
Authors: Deng Shi‐Hao , Yu Jun‐Xia , Xiao Hua‐Qing , Dong Zhi‐Bing 
Published: November 2022

AbstractA convenient and effective method for the construction of C−S bond under transition‐metal free conditions was reported. Thus, diverse thiocarbamide esters could be smoothly obtained in moderate to good yields from inexpensive and readily available starting materials, such as phenyl isothiocyanate, alcohols and benzyl halides. This method features mild conditions, easy operation, short reaction time and broad substrate scopes, providing a facile and convenient strategy for the preparation of some compounds with potential biological activities.
The role of the NLRP3 inflammasome in chronic inflammation in asthma and chronic obstructive pulmonary disease
Authors: Wu Yaxin , Di Xin , Zhao Min , Li Haoran , Bai Li , Wang Ke 
Published: November 2022

AbstractAsthma and chronic obstructive pulmonary disease (COPD) are lung diseases characterized by airflow limitation and chronic inflammation. More and more studies have shown that the occurrence and development of asthma and COPD are related to abnormal immune responses caused by dysregulation of many genetic and environmental factors. The exact pathogenesis of the disease is still unclear. A large number of studies have shown that the NLRP3 inflammasome is involved in the process of chronic airway inflammation in asthma and COPD. Here, we summarize recent advances in the mechanism of NLRP3 inflammasome activation and regulation and its role in the pathogenesis of inflammatory lung diseases such as asthma and COPD. Meanwhile we propose possible therapeutic targets in asthma and COPD.
Repair of uterine rupture following vaginal delivery: A comparison between minimally invasive and open repair
Authors: Stern Shira , Lessans Naama , Shveiky David , Saar Tal D. , Tevet Aharon , Dior Uri P. 
Published: November 2022

AbstractObjectiveTo compare operative data and patient satisfaction between open and laparoscopic surgery for postpartum‐diagnosed uterine rupture.MethodsIn this questionnaire‐based cohort study, the authors collected all cases of postpartum‐diagnosed uterine rupture after vaginal delivery between 2016 and 2020 in a single academic tertiary center. The cohort was divided according to surgical method of repair, and demographic, clinical, operative and postoperative data were collected and compared between groups. A phone questionnaire on various satisfaction domains was conducted and satisfaction rates were compared between groups.ResultsEight cases of uterine rupture following vaginal delivery were treated by laparoscopy and eight were treated by laparotomy. The median operative time was 103 min (interquartile range [IQR], 86.3–129.0 min) for the laparoscopy group and 61 min (IQR, 59.0–75.0 min) for the laparotomy group (P = 0.04). Blood transfusion was required in 25% of women who underwent laparoscopy, as compared with 88% of women who underwent laparotomy (P = 0.01 < 0.05). Median hospitalization time was 3 days (IQR, 3–4 days) in the laparoscopy group and 4 days (IQR, 4–4 days) in the laparotomy group (P = 0.2). Overall satisfaction, satisfaction from recovery, satisfaction from scars, satisfaction from ability to care for the neonate, and postoperative pain and mood were all improved in the laparoscopy group, as compared with the laparotomy group.ConclusionMinimally invasive surgery is a viable surgical option for patients with uterine rupture diagnosed after vaginal delivery and may result in better patient recovery and satisfaction.