bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iodine Staining With Distance Countdown Improving the Safety for Reduction of Adverse Events: A Randomized Controlled Trial
Authors: Xi Mingjia , Luo Xinyue , Chen Feifan , Wang Zhu , Xiao Xue , Luo Binyang , Chen Mo , Gan Tao , Yang Jinlin , Deng Kai 
Published: February 2025

INTRODUCTION:
Lugol chromoendoscopy (LCE) is valuable, cost-effective, and widely used in early esophageal cancer screening, yet it suffers from low compliance because of adverse events after LCE. In addition, the reflux of iodine during iodine staining in the upper esophagus brings the risk of bucking and aspiration. We introduced a new model called distance countdown (DC) aimed to reduce reflux during iodine staining in upper esophageal LCE.

METHODS:
In this randomized controlled trial, 204 patients were randomized into the DC and No-DC groups. The primary end point was the difference in the incidence of positive starch reagent reaction (iodine solution reflux) between the 2 groups. The secondary end points were the comparisons of the incidence of other adverse events after LCE between the 2 groups.

RESULTS:
The rate of iodine solution reflux was 1.0% in the DC group and 26.5% in the No-DC group (P < 0.001). Furthermore, the incidences of bucking between the 2 groups were 1.0% and 9.8% (P = 0.005). LCE satisfaction rates were 78.4% and 76.5% in the DC and No-DC groups (P = 0.363), respectively. Concerning symptoms after LCE, incidences of sore throat, pharyngeal discomfort or odor, bitter taste, and heartburn were also reduced in the DC group (all P < 0.05).

DISCUSSION:
Adding DC as an auxiliary effect during LCE would reduce the risk of iodine solution reflux, as well as other adverse events after LCE. Implementing this measure could be beneficial in improving the safety of LCE in early esophageal cancer screening.
Double band ligation–assisted endoscopic submucosal resection (ESR) for rectal neuroendocrine tumors: comparison with conventional endoscopic mucosal resection with ligation (with video)
Authors: Gao Yuan , Ye Liansong , Li Xu , He Long , Yu Bin , Liu Wei , Cao Yuwan , Chen Liuxiang , Mou Yi , Chen Ou , Xie Jia , Du Jiang , Zhang Qiongying , Hu Bing 
Published: February 2025

Background and Aims:
Based on endoscopic mucosal resection with ligation (EMR-L), we developed double band ligation–assisted endoscopic submucosal resection (ESR) for complete resection of small submucosal rectal neuroendocrine tumors (NETs). Both procedures use a multiband device to perform resection, with the only difference being that ESR adds an additional band to obtain deeper resection margin. This retrospective study aimed to validate its feasibility, safety, and effectiveness compared with EMR-L.

Methods:
This retrospective study included consecutive patients with small (≤ 10 mm) suspected submucosal rectal NETs who underwent ESR (n=45) or EMR-L (n=26) between June 2018 and October 2023 at West China Hospital. En bloc resection rate, complete resection rate, procedure time, margin distance and adverse events were compared between two groups.

Results:
En bloc resections were achieved in all patients. The complete resection rate of ESR was higher than EMR-L (100% vs. 88.5%, P=0.045). The vertical margin (VM) distance and lateral margin (LM) distance were significantly longer in ESR group than EMR-L group (VM distance 782.31 ± 359.45 μm vs. 363.84 ± 222.78 μm, P < 0.001; and LM distance 4205.75 ± 2167.43 μm vs. 3162.94 ± 1419.22 μm, P = 0.008, respectively). There were no significant differences in procedure time, adverse events, postprocedural hospital stay, or medical cost between two groups. In addition, there was no evidence of recurrence or metastasis during the follow-up.

Conclusions:
ESR appears to be safe and effective for complete resection of small submucosal rectal NETs. Larger, multicenter, prospective studies are needed to further assess this technique.
Lower extremity limb salvage in diabetic patients: the impossible is possible
Authors: Galstyan G. R. , Artemova E. V. , Bardiugov P. S. , Bondarenko O. N. , Dzhemilova Z. N. , Doronina L. P. , Egorova D. N. , Zaitseva E. L. , Mitish V. A. , Sergeeva S. V. , Sitkin I. I. , Tokmakova A. Y. , Yaroslavceva M. V. , Shestakova M. V. 
Published: February 2025

Lesions of the lower extremities in diabetes mellitus are a complex and urgent problem of modern medicine. The high prevalence of diabetes mellitus, significant difficulties in timely diagnosis, differential diagnosis and the choice of therapeutic tactics to preserve the supporting function of the limb determine the difficulties in managing diabetic patients. Over the past decades, significant changes have occurred in the structure of specialized medical care for diabetic foot patients which has significantly reduced the number of high amputations, improved the quality and life expectancy of patients. The article presents the results of the long-term experience of the Diabetic Foot department in the treatment of diabetic foot patients.
Multimodal (inter)action analysis in sociolinguistics: an essay analysing a digital video conversation illustrating emotion and heritage language maintenance
Authors: Bose Priyanka , Gao Xuesong (Andy) , Starfield Sue , Perera Nirukshi (Niru) 
Published: February 2025

Abstract
This essay demonstrates the use of multimodal (inter)action (MIA) analysis to examine the role of emotions in heritage language practice in transnational immigrant families between children and grandparents through digital communication media. The research uses Norris’s MIA framework and multimodal analytical tools to examine a video conversation between a grandmother residing in Bangladesh and her grandchild in Australia. Our study uncovers an intricate interplay of semiotic resources in digital interaction that reflects empathy and a strong emotional bond between the transnational grandparent and grandchild, where family bonding serves as the primary motivator of the conversation. While heritage language practice is visible, it plays a secondary role. We show how MIA can be used to capture the full spectrum of communication in an online video interaction, including the emotional dimensions often overlooked by traditional qualitative methods. Like other MIA studies, we introduce interview data into the analyses to provide a comprehensive understanding of the context of the video call. While our paper demonstrates the utility of MIA in sociolinguistics, it has implications for educators and families, emphasising the need for regular, emotionally engaging digital interactions to support heritage language maintenance and emotional well-being.
Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
Authors: Li Yu , Lv Xiaodan , Lin Jianing , Li Shiquan , Lin Guangfu , Huang Zhixi , Chen Deyi , Han Lichun , Zhan Lingling , Lv Xiaoping 
Published: February 2025

Abstract

Background
Non-alcoholic fatty liver disease (NAFLD) is a globally widespread disease. Recent investigations have highlighted a close association between immunity and NAFLD, but the causality between them has not been thoroughly examined.

Methods
A total of 731 immunological traits and NAFLD cohorts were derived from genome-wide association study summary data, and single nucleotide polymorphisms significantly associated with immune traits were identified as instrumental variables. Moreover, 731 phenotypes include absolute cell counts, median fluorescence intensity (MFI), morphological parameters, and relative cell counts. The bidirectional two-sample Mendelian randomization (MR) was performed primarily using the inverse-variance weighted methods, and sensitivity analysis was carried out simultaneously.

Results
Four immunophenotypes were identified to exert a protective effect against NAFLD, including HLA-DR+ CD4+ %lymphocytes, SSC-A on CD4+, CD24 MFI on IgD−CD38−, and CD8 MFI on CD28−CD8br. Seven immunophenotypes were identified to be hazardous, including CD28+ CD45RA+ CD8dim%CD8dim, CD127 MFI on CD28+ DN (CD4−CD8−), CD20 MFI on IgD+ CD38br, CD20 MFI on transitional, IgD MFI on transitional, CD3 MFI on central memory CD8br, and CD45 MFI on CD33brHLA-DR+ CD14−. However, reverse MR showed NAFLD had no causal effect on immunophenotypes.

Conclusion
The study demonstrated a potential causal link between several immunophenotypes and NAFLD, which contributes to advancing research and treatment of NAFLD based on immune-mediated mechanisms.
Biogenic synthesized selenium nanoparticles combined chitosan nanoparticles controlled lung cancer growth via ROS generation and mitochondrial damage pathway
Authors: Mahmood Rana I. , Al-Taie Alaa , Al-Rahim Aya M. , Mohammed-Salih Harraa S. , Ibrahim Humam Abdulrahman , Albukhaty Salim , Jawad Sabrean F. , Jabir Majid S. , Salem Mohamed M. , Bekhit Mounir M. 
Published: February 2025

Abstract
The green synthesis approach has drawn a lot of interest as an environmentally friendly and sustainable acceptable means of producing a diverse range of nanoparticles (NPs). This piece described a rapid approach for synthesizing selenium nanoparticles (SeNPs) with grape seed extract. A biologically active composition of selenium-chitosan nanoparticles (Se-chitosan NPs) has been prepared and characterized using, ultraviolet–visible, scanning electron microscopy, transmission electron microscopy, and zeta potential and size distribution experiments. To study the anticancer activity of prepared NP cytotoxicity (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay of chitosan nanoparticles (Chito-NPs), SeNPs were tested on two cancer cell lines: A549 and normal cell line (HK-2). In addition to a series of morphological changes, induction of apoptosis, reactive oxygen species (ROS) generation, and mitochondrial membrane potential. The results showed that the synthesized NPs were spherical with 55.285 and 30.9 nm, for SeNPs and Se-chitosan NPs, respectively. In the A549 cell line, SeNPs and Se-chitosan NPs exhibited dose-dependent cytotoxicity, with an IC50 for Chito-NPs of 24.09 µg/mL, whereas for SeNPs it was 18.56 µg/mL. Conversely, normal cell lines (MCF-10) were not significantly cytotoxically affected by SeNPs and Se-chitosan NPs. Additionally, SeNP and Se-chitosan NP treatment resulted in increased ROS generation and caused mitochondrial dysfunction. Based on ROS-mediated pathways, the results demonstrated that Chito-NPs, SeNPs, and Se-chitosan NPs cause apoptosis and death in A549 cells. As nanotherapeutics, Chito-NPs, SeNPs, and Se-chitosan NPs appear to offer a great deal of unrealized potential based on these findings. Further investigation is warranted and clinically significant to elucidate the specific therapeutic potential and safety of these NPs when applied in vivo. In this work, we show that exposure to SeNPs, Chito-NPs, and Se-chitosan NPs alters the human lung cancer cell line A549’s ROS route of signaling, thereby causing the induction of apoptosis.
Waste Around Longhouses: Taphonomy on LBK Settlement in Hlízov
Authors: Pilař Daniel , Denis Solène , Pavlů Ivan 
Published: February 2025

Abstract
The research investigates the waste management and taphonomy of a Linear Pottery Culture (c. 5600–4900 BC) settlements. Waste deposition significantly shaped the archaeological record of the Early Neolithic in Central Europe and its reconstruction fundamentally influences our perception of the settlement space and the daily life of Neolithic people. Traditionally, it has been assumed that individual households discarded waste near their longhouses. However, findings from the site Hlízov (Czech Republic) reveal a more complex waste management system, with designated disposal areas and differential treatment of various waste types. Additionally, two overlapping waste distribution networks were identified, indicating distinct models of production and waste management organisation. These settlement-wide networks were discovered due to the abandonment of the rigidly used house unit model, which appears to be inadequate for this site.
Technically Getting Off: On the Hope, Disgust, and Time of Robo-Erotics
Authors: McNealis Rachel 
Published: February 2025

Abstract
As robots evolve from functional machines to potential sexual companions, they embody both utopian hopes and dystopian fears. This article explores the ethical implications of sex robots, focusing on power dynamics, objectification, and gender performance. Through Ann Cahill’s concept of derivatization, the article argues for a nuanced understanding of sexual objectification in the context of robo-erotics. While sex robots offer new possibilities for intimacy and desire, they also risk reinforcing problematic gender norms and power structures. The article introduces a queer utopian framework, oscillating between hope and disgust, to examine how sex robots might subvert or perpetuate traditional scripts of sexuality. Ultimately, this work aims to situate sex robots within the broader landscape of technological advancement and its potential to reshape human sexuality.
La sabiduría de los griegos en la segunda parte de la «Monarquía Mística» de Lorenzo de Zamora
Authors: Seoane Rodríguez Manuel Andrés 
Published: February 2025

La segunda parte de la Monarquía mística de Lorenzo de Zamora se inicia con una argumentación sobre la conocida sentencia apolínea del conócete a ti mismo en consonancia con un versículo bíblico extraído del libro de Job. El esfuerzo del humanista se concentra en la elaboración de un mosaico de citas y referencias de los Siete Sabios y filósofos y eruditos griegos, procedentes sin duda de fuentes intermedias que, por un lado, apuntalan esta coincidencia y, por otro, demuestran la antigüedad y prevalencia del precepto bíblico en tanto que verdad revelada
Škorpion by Josip Kulundžić in the context of Croatian expressionism
Authors: Vuco Jurica 
Published: February 2025

The paper Škorpion by Josip Kulundžić in the context of Croatian expressionism will present a dramatic text Škorpion in the context of Croatian expressionism. Along with the dramatic text Ponoć, it is considered to be Kulundžić’s most significant dramatic work in terms of aesthetics and quality. Škorpion witnesses a strong expressionist genre and stylistic dramatic determination, while on the other hand it continues to implement the author’s, also specific, expressionist poetic framework. An overview of the most important features and characteristics of Croatian expressionism, the origin and duration of expressionist poetics within the corpus of Croatian literature, and the fundamental characteristics and basic elements of Croatian dramatic expressionism will be presented. Expressionist poetics dominated Croatian literary creativity until the mid-twen-ties of the 20th century and remained present until the end of that decade and in that period Josip Kulundžić was the most fruitfull expressionistic writer. The paper will provide a brief overview of the poetic principles of dramatic writing of Josip Kulundžić as well as the most important principles of his second phase of expressionist production.His second phase begins in 1926 with the dramatic text Škorpion which symbolizes the transition from his first to the second phase of his expressionist dramatic work. In this phase of the author’s work, expression-istic features are still dominant, but they begin to intertwine in places with realistic, sometimes naturalistic dramatic properties and psychological, social and existential dramatic signals that will characterize later drama. On the level of dramatic expression and content, expressionist features still stand out, but they are no longer so extreme and radical, and the concept of original, German dramatic expressionism replaces the view of Croatian dramatic expressionism and its already mentioned, specific features that will be present in all Croatian expressionist dramatists of the third decade of the 20th century. In the second phase of his expressionist dramatic creation, his plays will increasingly take on the characteristics of national literary and theatrical expressionism, thus securing Kulundžić’s position as one of the most prominent and prolific expressionist playwrights of Croatian expressionism. The paper will present typical and paradigmatic expressionist features in all segments of the dramatic text, from the plan of expression through stylistic features to the content part of the text. Also, the paper will present the characteristics of typical expressionist characters with an emphasis on the main character, the expressionist ironic anti-hero.
Dynamic Seating in Learners with Down's Syndrome in South Africa
Authors: Reyneke Lise Kathleen , Hoosain Munira 
Published: February 2025

Introduction: The study aimed to investigate whether the classroom behaviour and task performance of learners with Down syndrome improved with the use of a stability ball as a classroom chair.Method: A single-subject withdrawal design was utilised. There were three participants, aged ten to twelve, with Down syndrome in a special education classroom. Five phases of three weeks each were implemented alternately. Two phases incorporated usual classroom chairs and the other three phases made use of stability balls as chairs. Momentary time sampling was used to record learners' classroom behaviours in relation to their in-seat and on-task performance.Results: A substantial positive change was found in the learners' on-task performance when seated on stability balls instead ofof chairs. Results differed across participants; with some demonstrating a definite difference in the usual daily average on-task performance, while others showed steadier patterns of on-task behaviour in comparison with their usual fluctuating levels of attention.Conclusion: Stability ball seating is a non-invasive intervention strategy that can be effectively utilised in classrooms and occupational therapy clinical settings, to improve on-task behaviour in learners with Down syndrome
Key words: Dynamic seating, Down syndrome, attention, in-seat behaviour, on-task behaviour
Heltai Gáspár Biblia-idézési módszere életművében
Authors: Kőrösi Ferenc 
Published: February 2025

A tanulmány fő kérdése, hogy Heltai Gáspár milyen módszerrel idéz a Bibliából saját munkáiban. A kiindulópontot az a Pázmány Péter munkái kapcsán megfogalmazott nézőpont adja, miszerint Pázmány tudatos módszert alakított ki az idézéshez. Annak feltárásához, hogy Heltai alkalmazott-e valamilyen tudatos szerkesztési metódust e tekintetben, illetőleg, milyen elvek figyelhetőek meg, a vizsgálat középpontjában a Heltai művek elemzése állt. Kutatásaim során négy kérdés mentén vizsgáltam a Heltai szövegekben található bibliai idézeteket. Arra kerestem választ, hogy milyen kapcsolatban állnak a művekben található idézetek Heltai részleges Biblia-fordításaival. Emellett az is a vizsgálat tárgya volt, hogy egy idézet többszöri megjelenése esetében azonos, vagy eltérő formában került-e erre sor. Az összehasonlító és szövegelemző vizsgálatok arra mutattak rá, hogy éles határ húzható meg az idézés módszerében Heltai korai és késői munkásságában. Míg korai munkáiban Heltai többnyire szó szerint idézi a Biblia szövegét (főképp az Ószövetség könyveit), addig kései műveiben már elsősorban átdolgozásokkal, paratextusokkal találkozunk. Ennek két oka lehet. Az első, hogy míg korai munkái megjelenésekor már rendelkezésére állt Heltainak az Ószövetség fordításának nagy része, addig az Újszövetségé nem. A másik ok abban látható, hogy Heltai, munkásságának második felében, áttért a dogmatikai kiadványok megjelentetéséről az erkölcsi példákat nyújtó történetek közreadására. Míg előbbi esetében a tévtanok elkerülése megkövetelte a pontos idézést, addig az utóbbi nyomtatványok esetében fontosabb volt az idézetek beágyazása a szövegbe.
Seafloor Seismic Noise Patterns Across the Pacific Basin
Authors: Niklasson Siobhan , Rowe Charlotte , Bilek Susan 
Published: February 2025

Abstract
Seismic hazard monitoring and global tomography efforts are improved by recording signals at a variety of distances and azimuths to maximize subsurface sampling. Although seismic networks provide good to excellent coverage on land, seafloor stations are still sparse. Inclusion of ocean-based data would greatly improve the global coverage of seismic networks, but the use of seafloor seismic data to complement land-based detection and characterization of events is complicated by the generally much higher ambient noise level in the ocean compared to that observed on land. This noise is driven primarily by sea surface waves and tides, but how seismic noise levels vary with location in the oceans is not well described. Here, we analyze the relationship between ocean surface wave height and seismic noise in the 0.4–4 Hz frequency band at ocean-bottom seismometer deployments across the Pacific basin. We find that a noise-to-responsiveness ratio (NRR)—the median noise level at a station divided by its sea surface wave height responsiveness—correlates negatively with detection success for large teleseismic earthquakes. Stations that are close to land, with relatively shallow ocean and low wind speed, often have lower NRR than open-ocean stations, but the connection between geographic location and earthquake detection success is imperfect.
Role of saliva buffer capacity for caries risk assessment in adults using a reduced cariogram model
Authors: Kasireddy Himasree , Tanikonda Rambabu , Mamidibathula Sri Devi , Malkapuram Rani Sirisha 
Published: February 2025

A reduced cariogram model is a simplified version of the original cariogram which simplifies the analysis by focusing on fewer parameters, making it easy to use in clinical and research settings. One of the key components in “cariogram model” is the buffering capacity of saliva, which plays a pivotal role in maintaining oral pH balance. To investigate the role of “salivary buffer capacity” for caries predictive ability of “reduced cariogram model” in adults.A sample of 90 patients were included in this study. The cariogram variables were collected through a questionnaire, clinical and salivary examinations. The outcome measure was computed as a ‘‘chance to avoid caries in the near future,’’ which was expressed in percentage. The eight cariogram variables computed were caries experience, related diseases, diet frequency, plaque amount, fluoride program, saliva secretion, saliva buffer capacity, and clinical judgment. The data were calculated in two ways: “cariogram with eight variables” and “cariogram with seven variables”, excluding saliva buffer capacityThe patients were then allocated into three caries risk categories according to their chance of avoiding caries in the near future, as follows: 0–40% chance to avoid caries =high caries risk, 41–60% chance to avoid caries = medium caries risk, and 61–100% chance to avoid caries = low caries risk in both models i.e “cariogram with eight variables” and “cariogram with seven variables”. Comparison between the two was done. When eight variables were considered the p value was 0.150 and when only seven variables were considered the p value was 0.001 which is statistically significant indicating the saliva buffer capacity has an influence in the caries risk assessment of an individual.: Saliva buffer capacity had a significant role in altering the caries risk of an individual in a “reduced cariogram model”.