bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic HER3 ligand-mimicking bioparticles cross the blood–brain barrier reducing intracranial triple-negative breast cancer growth
Authors: Alonso-Valenteen Felix , Sances Sam , Wang HongQiang , Mikhael Simoun , Sims Jessica , Taguiam Michael , Srini Dustin , Sanchez Romny , Serrano Erik , Ondatje Briana , Teh James , Wong Michelle , Nguyenle Kimngan , Miao Tianxin , Benhaghnazar Rebecca , Yu John , Svendsen Clive , Abrol Ravinder , Kauwe Lali Medina 
Published: January 2022

Abstract

Triple-negative breast cancer (TNBC) lacks selective biomarkers targeted by current clinical therapies and often metastasizes to the brain. Crossing the blood-brain barrier (BBB) and reaching intracranial tumors is a clinical challenge contributing to poor prognoses for patients. The human epidermal growth factor receptor HER3 has emerged as a biomarker of metastasis and may provide a means of therapeutically targeting TNBC. We have developed HER3-targeted biological particles (bioparticles) that exhibit systemic homing to resistant and metastatic breast tumors. Here we show that HER3 is expressed on the brain endothelium and can mediate the passage of bioparticles across the BBB and into intracranial TNBC. Our findings show that the extravasation of systemic bioparticles in mice and in human induced pluripotent stem cell-based BBB chips corresponds to HER3 levels. Furthermore, systemically delivered bioparticles carrying tumoricidal agents reduced the growth of intracranial TNBC in mice and exhibited improved therapeutic profile compared to current therapies.
Assessing the Sustainability Index of Part-Time and Full-time Hazelnut Farms in Giresun and Ordu Province, Turkey
Authors: YILDIRIM Çağatay , Türkten Hatice , BOZ İsmet 
Published: January 2022

Abstract
The study's primary purposes were to assess the sustainability index of hazelnut farms and explore the effects of part-time and full-time farming types on sustainability index in hazelnut production in the Giresun and Ordu Province of Turkey. One hundred fifty-two hazelnut farms were selected using the stratified sampling method, and data were collected. Several steps were taken, including using factor analysis after standardizing the variables to determine their weights to calculate the composite hazelnut farms sustainability index. The research findings showed that overall hazelnut sustainability scores of farms varied from 0.28 to 0.59, and the average score was 0.44 at sampled farms. The composite hazelnut sustainability index was at an unsatisfactory level. The social and economic sustainability index value of farms was equal, and they were higher than the environmental index value. The values were 0.50 and 0.30, respectively. While the economic sustainability index score of full-time farms was higher than that of part-time farms, and part-time farms had higher environmental sustainability index scores than that of full-time farms. Social sustainability scores were not different in terms of farm type. It was recommended that when designing and regulation support policies, policy-makers should differentiate part-time and full-time hazelnut farming. Training and extension programs must be planned to increase the level of knowledge of every willing farmer. In addition, training and certification programs must be implemented to enhance the quality of the foreign labor force.
Proposing Several Model Techniques Including ANN and M5P-tree to Forecast the Stress at the Failure of Geopolymer Concrete Mixtures Incorporated Nano-silica
Authors: Ahmed Hemn Unis , Mohammed Ahmed S. , Mohammed Azad A. 
Published: January 2022

Abstract
Geopolymers are innovative cementitious materials that can completely replace traditional Portland cement composites and have a lower carbon footprint than Portland cement. Recent efforts have been made to incorporate various nanomaterials, most notably nano-silica (nS), into geopolymer concrete (GPC) to improve the composite's properties and performance. Compression strength (CS) is one of the essential properties of all types of concrete composites, including geopolymer concrete. As a result, creating a credible model for forecasting concrete CS is critical for saving time, energy, and money, as well as providing guidance for scheduling the construction process and removing formworks. This paper presents a large amount of mixed design data correlated to mechanical strength using empirical correlations and neural networks. Several models, including artificial neural network, M5P-tree, linear regression, nonlinear regression, and multilogistic regression models were utilized to create models for forecasting the CS of GPC incorporated nS. In this case, about 207 tested CS values were collected from literature studies and then analyzed to promote the models. For the first time, eleven effective variables were employed as input model parameters during the modeling process, including the alkaline solution to binder ratio, binder content, fine and coarse aggregate content, NaOH and Na2SiO3 content, Na2SiO3/NaOH ratio, molarity, nS content, curing temperatures, and ages. The developed models were assessed using different statistical tools such as RMSE, MAE, SI, OBJ value, and R2. Results revealed that the ANN model estimated the CS of GPC incorporated nS more accurately than the other models. On the other hand, the alkaline solution to binder ratio, molarity, NaOH content, curing temperature, and ages were those parameters that have significant influences on the CS of GPC incorporated nS.
Translation and Validation of M.D. Anderson Symptom Inventory-Thyroid Cancer Module in Chinese Thyroid Cancer Patients: A Cross-Sectional and Methodological Study
Authors: Hu Ziyi , Gou Juxiang , Cai Ming , Zhang Yueer 
Published: January 2022

Abstract
Aim

To translate and validate the Chinese version of the MDASI-THY among thyroid cancer patients.
Background

The M.D. Anderson Symptom Inventory-Thyroid Cancer module (MDASI-THY) is one of well-validated instruments for thyroid-specific symptom assessment. To date, the instrument has not been used in China.
Methods

After standard forward- and back-translation procedures, two instruments, the Chinese version of MDASI-THY and the European Organization for Research and Treatment of Cancer QLQ C30, were answered by 309 thyroid patients. The content, convergent discriminant validity and reliability of the MDASI-THY were evaluated. The Standards for Reporting Diagnostic Accuracy Studies (STARD) was used as reporting checklist.
Results

S-CVI and I-CVI of the instrument were over 0.80. There were significant relationships between MDASI-THY and EORTC QLQ-C30 (p<0.001). Symptoms were severer for patients underwent surgical treatment. The Cronbach’s alpha was 0.966 (between 0.954 and 0.827 for subscales). Most symptom items had moderate to high interitem correlations.
Conclusions

The Chinese version of MDASI-THY demonstrated favorable validity and reliability. It can be used in development of symptom management program in thyroid cancer patients in China.
Relevance to clinical practice:

Nurse can apply this instrument to assess Chinese thyroid cancer patients to increase the understanding of their symptom experience, resulting in a better symptom management.
Pharmacokinetic Parameter Driven Outcomes Model Predicts a Reduction in Bleeding Events Associated with BAY 81-8973 Versus Antihemophilic Factor (Recombinant) Plasma/Albumin- Free Method in a Chinese Healthcare Setting
Authors: Chen Rong , Gultyaev Dmitry , Lister Johanna , Han Rong , Hu Nan , Malacan Jean , Solms Alexander , Vashi Parth , O’Hara Jamie , Hu Shanlian 
Published: January 2022

Abstract
Background: Long-term prophylactic therapy is considered the standard of care for hemophilia A patients. This study models the long-term clinical and cost outcomes of two factor VIII (FVIII) products using a pharmacokinetic (PK) simulation model in a Chinese population. Methods: Head-to-head PK profile data of BAY 81-8973 (KOVALTRY®) and antihemophilic factor (recombinant) plasma/albumin-free method (rAHF-PFM, ADVATE®) were applied to a two-state (alive and dead) Markov model to simulate blood FVIII concentrations at a steady state in prophylactically-treated patients with hemophilia A. Worsening of the Pettersson score was simulated and decline was associated with the probability of having orthopaedic surgery. The only difference between the compounds was FVIII concentration at a given time; each subject was treated with 25 IU/kg every 3 days. The model used a lifetime horizon, with cycle lengths of 1 year. Results: Cumulative bleeding events, joint bleeding events, and major bleeding events were reduced by 19.3%, 9.3% and 19.3%, respectively for BAY 81-8973 compared to rAHF-PFM. Hospitalizations and hospitalization days were also reduced by 19.3% for BAY 81-8973 compared to rAHF-PFM. BAY 81-8973 resulted in both cost savings and a gain in quality adjusted life years (QALYs) compared to rAHF-PFM. Conclusion: Based on modeled head-to-head comparisons, differences in PK-properties between BAY 81-8973 and rAHF-PFM result in a reduced number of bleeding events, leading to reduced costs and increased quality of life for BAY 81-8973. These results should be used to inform clinical practice in China when caring for patients with severe hemophilia A.
Associations of maternal plasma and infant umbilical cord blood plasma metabolomics profiles with anthropometric measures at birth: a prospective cohort study.
Authors: Yeum Dabin , Gilbert-Diamond Diane , Doherty Brett , Coker Modupe , Stewart Delisha , Kirchner David , McRitchie Susan , Sumner Susan , Karagas Margaret , Hoen Anne 
Published: January 2022

Abstract
BackgroundThe metabolomics profiles of maternal plasma during pregnancy and cord plasma at birth might influence fetal growth and birth anthropometry. The objectives of this study are to examine how metabolites measured in maternal plasma samples collected during pregnancy and umbilical cord plasma samples collected at birth are associated with newborn anthropometric measures, a known predictor of future health outcomes.MethodsPregnant women between 24 and 28 weeks of gestation were recruited from prenatal clinics in New Hampshire as part of a prospective cohort study. Blood samples from 413 women at enrollment and 787 infant cord blood samples were analyzed using the Biocrates AbsoluteIDQ® p180 kit . Multivariable linear regression models were used to examine association of cord and maternal metabolites with infant anthropometry at birth.ResultsIn cord blood samples, several acylcarnitines, a phosphatidylcholine, and a custom metabolite indicator were negatively associated with birth weight Z-score, and lysophosphatidylcholines as well as three custom metabolite indicators were positively associated with birth weight Z-score. Acylcarnitine C5 was negatively associated with birth length Z-score, and several lysophosphatidylcholines and a custom metabolite indicator were positively associated with birth length Z-score. Maternal blood metabolites did not show significant associations with birth weight and length Z scores, however, a custom metabolite indicator, the ratio of kynurenine over tryptophan, was negatively associated with weight-for-length Z-score.ConclusionsSeveral cord blood metabolites associated with newborn weight and length Z-scores; in particular, consistent findings were observed for several acylcarnitines that play a role in utilization of energy sources, and a lysophosphatidylcholine that is part of oxidative stress and inflammatory response pathways. Fewer associations were observed with maternal metabolomic profiles.
The Trend of Dental Check-Up And Incidence of Dental Complications Following The Use of Bone Modifying Agents In Patients With Metastatic Breast And Prostate Cancer: Analysis of Data From The Korean National Health Insurance Service
Authors: Lim Ah Reum , Park Wonse , Moon Seok Joo , Kim Min Sun , Lee Soohyeon 
Published: January 2022

Abstract
Purpose: Bone-modifying agents (BMAs) are key components in the management of cancer patients with bone metastasis. Despite their clinical benefits, the use of BMAs is associated with adverse dental events including medication-related osteonecrosis of the jaw (MRONJ). This study investigated the rate of preoperative dental surveillance to reduce the incidence of adverse dental events including MRONJ after BMA treatment in patients with bone metastasis from breast and prostate cancer. Methods: Data, including age, cancer diagnosis, administered BMAs, and adverse dental events during cancer treatment, of patients with bone metastasis from breast and prostate cancer who received at least one infusion of BMA between 2007 and 2019 were extracted from the Korean National Health Insurance Service (KNHIS) dataset. Results: Of the 15357 patients who received BMAs, 1706 patients (11.1%) underwent dental check-ups before BMA treatment. The proportion of patients receiving dental check-ups increased from 4.4% in 2007 to 16.7% in 2019. Referral for dental check-up was more frequent in clinics and primary hospitals than in tertiary hospitals, and from the departments of internal medicine and urology than from the department of general surgery, regardless of the patient's health insurance status. After BMA treatment, 3328 patients (21.6%) developed adverse dental events, including tooth extraction (73.0%), abscess (16.9%), acute periodontitis (5.3%), acute pericoronitis (2.6%), and MRONJ (2.2% of 3328, 0.5% of 15357). Conclusions: Considering the long treatment period in patients with metastatic cancer, coordination between dentists and oncologists is necessary to ensure appropriate dental treatment before the initiation of BMAs.
Visual Outcomes of Macula-Involving Rhegmatogenous Retinal Detachment in Patients with and Without Age-Related Macular Degeneration
Authors: Paulk P. Barrett , Eloubeidi Dala , III John O. Mason , Curcio Christine A. , Crosson Jason N. , Johnson Mark , Swain Thomas 
Published: January 2022

Abstract
Background

Patients presenting with macula-off rhegmatogenous retinal detachment (RRD) with concomitant age-related macular degeneration (AMD) and their treating physicians would benefit from knowledge regarding the visual prognosis after repair. The prognosis for such patients is not well known. The purpose of this study is to compare visual outcomes in macula-off RRD in eyes with AMD versus a group of comparison eyes without AMD.
Methods

This was a retrospective chart review of 1,149 patients. A total of 191 eyes met study criteria, 162 non-AMD eyes (controls) and 29 AMD eyes. The main outcome measure was postoperative visual acuity in control eyes versus AMD eyes, and this was compared using Fisher’s exact test.
Results

There was a statistically significant difference in postoperative visual acuity by AMD status, with those without AMD having a higher frequency of Count Fingers (CF), Hand Motion (HM), Light Perception (LP), or No Light Perception (NLP) vision (p = 0.023). More specifically 5.56% of non-AMD eyes and 3.45% of AMD eyes were 20/40 or better, 77.16% of non-AMD and 55.17% of AMD eyes were worse than 20/40 and better than 20/200, 10.49% of non-AMD eyes and 37.93% of AMD eyes were 20/200 or worse, and there were 11 eyes in the non-AMD group with CF, HM, LP, or NLP vision while there was only 1 eye in the AMD group with CF vision.
Conclusions

Though postoperative visual acuity was worse in the non-AMD group with a higher frequency of patients having final vision of CF, HM, LP, or NLP, this is not likely a clinically significant finding. Rather, it is a function of the difference in sample size and composition between the two groups. Importantly, this study suggests AMD patients can expect similar outcomes to non-AMD patients after RRD repair. Our study suggests that approximately 58% of patients with AMD can expect to maintain functional vision better than 20/200. We conclude that AMD patients can achieve functional vision after RRD surgery, similar to those without AMD. These findings may be helpful in guiding realistic expectations of AMD patients with RRD.
A hybrid integrated dual-microcomb source
Authors: Dmitriev Nikita , Koptyaev Sergey , Voloshin Andrey , Kondratiev Nikita , Lobanov Valery , Min'kov Kirill , Riabko Maksim , Polonsky Stanislav , Bilenko Igor 
Published: January 2022

Abstract
Dual-comb interferometry is based on self-heterodyning two optical frequency combs, with corresponding mapping of the optical spectrum into the radio-frequency domain. The dual-comb enables diverse applications, including metrology, fast high-precision spectroscopy with high signal-to-noise ratio, distance ranging, and coherent optical communications. However, current dual-frequency-comb systems are designed for research applications and typically rely on scientific equipment and bulky mode-locked lasers. Here we demonstrate for the first time a fully integrated power-efficient dual-microcomb source that is electrically driven and allows turnkey operation. Our implementation uses commercially available components, including distributed-feedback and Fabry--Perot laser diodes, and silicon nitride photonic circuits with microresonators fabricated in commercial multi-project wafer runs. Our devices are therefore unique in terms of size, weight, power consumption, and cost. Laser-diode self-injection locking relaxes the requirements on microresonator spectral purity and Q-factor, so that we can generate soliton microcombs resilient to thermal frequency drift and with pump-to-comb sideband efficiency of up to 40% at mW power levels. We demonstrate down-conversion of the optical spectrum from 1400 nm to 1700 nm into the radio-frequency domain, which is valuable for fast wide-band Fourier spectroscopy, which was previously not available with chip-scale devices. Our findings pave the way for further integration of miniature microcomb-based sensors and devices for high-volume applications, thus opening up the prospect of innovative products that redefine the market of industrial and consumer mobile and wearable devices and sensors.
Assessment of faecal contamination in selected concrete and earthen ponds stocked with Clarias gariepinus
Authors: OLALEMI ADEWALE OLUWASOGO , OLUYEMI OLUWABUSAYOMI MARY , BAYODE MICHAEL TOSIN 
Published: January 2022

Abstract
Background

This study was carried out to monitor the levels of faecal pollution markers in catfish (Clarias gariepinus) and their growing waters in selected earthen and concrete ponds. Water and catfish samples were collected weekly in the months of February, March, April, May, June and July, 2019. The concentrations of enteric bacteria in the water and catfish samples were determined using membrane filtration and pour plate methods, respectively. The rate of bioaccumulation of faecal indicator bacteria was obtained by dividing the log concentration of each organism in catfish by the corresponding log concentration in the growing waters.
Result

The concentration of faecal coliforms in catfish samples from concrete and earthen ponds ranged from 1.41 to 2.28 log10 CFU/100 ml and 1.3 to 2.47 log10 CFU/100 ml respectively and in growing waters from the concrete and earthen ponds; 1.43 to 2.41 log10 CFU/100 ml and 1.50 to 2.80 log10 CFU/100 ml respectively. Faecal coliforms exhibited positive relationships with alkalinity in water samples from the earthen (r = 0.61) and concrete ponds (r = 0.62). Salmonella and faecal coliforms had the highest and least bioaccumulation in catfish raised in earthen pond, respectively, whereas Salmonella and enterococci had the highest and least bioaccumulation in catfish raised in concrete pond, respectively. Faecal coliforms and E. coli had the highest and least counts in water samples from the earthen pond during the dry and wet months, Salmonella and E. coli had the highest and least counts in water samples from the concrete pond during the dry and wet months.
Conclusion

There were high levels of bacterial faecal pollution markers in water and C. gariepinus from the earthen and concrete ponds. Physicochemical characteristics of the water and seasonality played major roles in the rate of bioaccumulation of the faecal pollution markers in C. gariepinus raised in the earthen and concrete ponds.
Us and Mri Neurography Assessment of Diagnostic Criteria in Patients With Carpal Tunnel Syndrome Using Electrophysiological Tests as Gold Standard: A Prospective Study
Authors: AlKaphoury Mona Gamalludin , Dola Eman Farouk 
Published: January 2022

Abstract
BackgroundPeripheral neuropathy evaluation depends mainly on physical examination, patient history, electrophysiological studies, with evoked potential abnormalities. High-resolution US has the advantage of being fast, non-invasive modality with nerve dynamic assessment allowing examination of long part of nerve. MR imaging serve better in examination of deeper nerves with higher contrast resolution. It shows great benefit in patient with atypical presentation, Equivocal diagnosis and suspicious of secondary cause and post-surgical relapse.MethodsThis study was conducted prospectively on 32 patients, presented with carpal tunnel syndrome diagnosed by electrophysiological tests. Superficial US of the wrist joint was done to all participants followed by MRI within 1 weeks of the US.We aimed to assess the measurements & criteria of both US & MRN in diagnosis of CTS, depending mainly on the three-measurement assessed by Buchberger et al., then to find the agreement between US & MR Neurography (MRN)ResultsUs proved to have higher rate of CTS prediction, the three main parameters CSA measurement, distal nerve flattening and flexor retinaculum bowing indices showed positive occurrence of 93.7%,59.4% &59.4% respectively. While we found that decreased nerve echotexture was positive in 90.6% of patients.Regarding MRI it showed less diagnostic ability when using CSA measurement as it was positive in 81.2% of patients, also distal tunnel nerve increased flattening and bowed flexor retinaculum positive results were slightly decreased to 56.2% for each. In contrast to high T2 signal of median nerve which was positive in 90.6% of patients.In agreement study, we found statically significant difference supporting US as the primary diagnostic modality of CTS depending mainly on the three measurement CSA, Flattening and bowing indices. Yet, for cases of secondary CTS and detection of underlying entrapping cause as well as innervated muscle early abnormality detection and better tissue characterization, MRI was better diagnostic modality with statistically significant difference. ConclusionsOur results proved that ultrasound examination can be used as first imaging modality after physician evaluation with comparable results to electrophysiological studies in evaluating CTS and try to find the cause. MRN examination came as second step in patients with suspected muscle denervation changes that could not be elicited by US or equivocal cases for detection of secondary cause in clinically suspected patient.