bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Report on Nanomaterial Catalysed Environmentally Benign Synthesis of Pyrido[2,3-d]pyrimidine Derivatives
Authors: Rishi Harsha , Singh Pratap , Sain Anushka , Kanwar Neeraj , Bhargava Sangeeta 
Published: February 2025

Abstract:
Nowadays, green chemistry is a fast developing innovative field that leads to eco-friendly results for
the future of science and technology. Designing reactions based on green principles is of great interest with
exceptional physical, biological, or pharmaceutical properties. Replacement of chemical methods with environmentally
benign processes for the sake of the environment is a need of society. Heterocycles are a fundamental
component of many pharmaceuticals, including medications, vitamins, chemical molecules, and solvents.
Heterocyclic compounds such as Pyrido[2,3-d]pyrimidine are widely distributed in nature. It helps in the
development of various therapeutic agents. In this connection, nanotechnology provides a vast area for the synthesis
of these compounds. Therefore, chemists have focused on the synthesis of these derivatives using nanomaterials
due to their large surface-to-volume ratio and simple, effective, moderate conditions of utilization.
Tiny Dots, Big Impact: The Antimicrobial Power of Carbon Dots
Authors: Borgohain Ranadeep , Islam Md Moidul , Kaur Harpreet , Kaur Harmanjot , Kumar Amit , Raikwar Sarjana 
Published: February 2025

Abstract:
Carbon Dots (CDs) are innovative nanoscale carbon-based materials rec-ognized for their exceptional optical properties, biocompatibility, and minimal tox-icity. These fluorescent nanoparticles, generally smaller than 10 nm, exhibit strong photoluminescence and absorption capabilities, which make them valuable for diverse applications in biomedicine, sensing, catalysis, and antibacterial technologies. Since their discovery in carbon soot in 2004, CDs have attracted attention for their environ-mental friendliness and versatile preparation methods, such as top-down (e.g., laser ablation, arc discharge) and bottom-up (e.g., hydrothermal treatment, microwave irra-diation) approaches. Functionalized with various surface groups, CDs offer excellent solubility and customizable properties for specific applications. One of the most prom-ising uses of CDs is as antibacterial agents, particularly against multidrug-resistant pathogens in the fight against bacterial infections. Their antibacterial mechanism in-volves generating Reactive Oxygen Species (ROS), which cause oxidative stress in bacterial cells, ultimately leading to cell death. Studies demonstrate the effective anti-bacterial action of CDs against bacteria such as E. coli and Staphylococcus aureus, attributed to ROS generation and membrane-penetrating effects. Despite challenges like synthesis consistency and potential toxicity, advancements in eco-friendly pro-duction and combination with other antimicrobial agents present exciting possibilities. CDs emerge as sustainable alternatives to traditional antibiotics, offering a valuable tool for advancing infection control in nanotechnology and global health contexts
Identification and Characterization of Biosurfactant-producing Novel Paenibacillus dendritiformis Strain ANSKLAB02 from Brackish River Water
Authors: Nayarisseri Anuraj , Bhrdwaj Anushka , Sharma Khushboo , Khan Arshiya , Singh Sanjeev Kumar 
Published: February 2025

Introduction:
Biosurfactants are the surface-active reagents produced by microorgan-isms, which exhibit the non-toxic and augmented bioavailability potential for the decomposition of petro-based pollutants and performing microbial-enhanced oil recovery (MEOR).

Methods:
Thus, the present study entails the isolation of a novel biosurfactant-producing bacteria in MSM medium containing crude oil as a sole carbon source. Biosurfactant screening, cultural, and statistical optimization; Plackett - Burman Design, and response surface methodology (RSM) in conjunction with the Box-Behnken experimental design was employed for examining the bio-surfactant producing potential, and emulsification activity of the Paenibacillus strain, which ren-dered a maximum E24 index as 70%, with reduced surface tension of 29 mN/m.

Result:
The novel isolate was identified and named Paenibacillus dendritiformis strain AN-SKSLAB02 and the sequence was deposited in the NCBI-GenBank database with accession num-ber “KU518891”.

Conclusion:
The results signify that the bacterium holds the potential to burgeon in harsh condi-tions which is an appropriate habitat for application in MEOR, which has great potential to aid in environmental cleanup.
Lacticaseibacillus rhamnosus DTA 73 Exhibits Superior Anti-Adhesion Activity against Salmonella Typhimurium DTA 41 in Caco-2 cells
Authors: Rodrigues Silva do Carmo Matheus , Oliveira Alves Moreira de Carvalho Gabriella , Batista dos Santos Rodrigo , Fioravante Guerra André , da Silva de Azevedo Fortes Fabio , Luchese Rosa Helena 
Published: February 2025

Background:
A challenge in choosing probiotic strains is to identify, in each one,
specific positive health effects to offer a tailored product. An important health claim of probiotics is
the competitive exclusion of pathogens and the consequent prevention and treatment of diarrhea.

Objective:
The aim of the study was to evaluate the ability of lactobacilli strains to adhere to intestinal
epithelial Caco-2 cells and to inhibit Salmonella adhesion in vitro and in situ.

Methods:
The ability to inhibit Salmonella biofilms by four strains of Lacticaseibacillus paracasei,
three strains of Lacticaseibacillus rhamnosus, two strains of Limosilactobacillus fermentum, and a
commercial strain of Lacticaseibacillus casei, was evaluated in vitro on hydrophobic polystyrene
surfaces and in situ using Caco-2 cells.

Results:
All strains showed a high adhesion capacity to Caco-2 cells, with no significant difference
between isolated strains and the commercial probiotic strain. In polystyrene surfaces, inhibition of
Salmonella biofilms by lactobacilli through the competition and exclusion mechanisms was significantly
more effective when compared to displacement. However, in Caco-2 cells, the isolates were
more effective in inhibiting Salmonella biofilms.

result:
All strains showed a high adhesion capacity to Caco-2 cells, with no significant difference between isolated strains and the commercial probiotic strain. In polystyrene surface, inhibition of Salmonella biofilms by lactobacilli through the competition and exclusion mechanisms was significantly more effective when compared to displacement. However, in Caco-2 cells the isolates were more effective in inhibiting Salmonella biofilms.

Conclusion:
It is concluded that hydrophobicity was not a good indicator of adhesion capability.
Although all lactobacilli strains have low cell surface hydrophobicity, they showed high adhesion
capacity in Caco-2 cells. The most promising strain, Lacticaseibacillus rhamnosus DTA 73, was
able to inhibit Salmonella adhesion in Caco-2 cells by competition, exclusion and displacement with
the same efficiency, suggesting that it could be effective not only in preventing but also in treating
diarrhea.
A Perspective Review on Animal Coronaviruses: From Infection Insights to Preventive Measures and Antiviral Advancements
Authors: - Tanvi , Goyal Rajat , Gautam Rupesh K. , Wilson Kashish , Garg Kajal , Sharma Tanmay , Gupta Sumeet , Singh Sachin Kumar , Ali Haider , Gupta Gaurav , Hussain Md Sadique 
Published: February 2025

Abstract:
Animal coronaviruses (CoVs) have emerged as significant pathogens with considerable
implications for both animal and human health. This review provides an in-depth analysis of the
origins, transmission dynamics, and pathogenic mechanisms of animal CoVs. We examine the viral
entry, replication processes, and immune evasion strategies that enable CoVs to infect a variety of
host species. Additionally, the review highlights recent advancements in prevention and therapeutic
strategies, including the development of species-specific vaccines, enhanced biosecurity measures,
and surveillance systems aimed at controlling zoonotic spillover. Furthermore, we discuss the latest
antiviral strategies, including repurposed drugs, targeted molecular therapies, and the development of
novel antiviral agents. This review emphasizes the importance of interdisciplinary research in
advancing our understanding of animal CoVs and in developing effective interventions to mitigate
their impact on global health.
IPR and Blockchain Technology: Opportunities and Risks for the Digital Economy
Authors: Panda Brajesh Kumar , . Diksha , . Komal , Singh Amandeep 
Published: February 2025

Abstract:
Blockchain technology is a decentralized, peer-to-peer network-based public, en-crypted, and immutable digital federated ledger system with various applications in the digi-tal economy. This paper examines how blockchain technology can strengthen intellectual property rights (IPR) in the digital age and the potential challenges and risks associated with this use. The paper analyses the advantages and disadvantages of blockchain technology for confirming and protecting IPR, such as transparency, security, efficiency, and scalability, as well as issues such as legal uncertainty, interoperability, and governance. The paper also ex-plores the implications of blockchain technology for different types of IPR, such as patents, and copyrights, and how it can facilitate innovation, licensing, and enforcement. The paper concludes by providing recommendations for improving the legal and regulatory framework for IPR management using blockchain technology and identifying some areas for further re-search.
Agomelatine Transdermal System Product Cycle: Development, Material/Process Screening, Optimization, Characterization, Delivery Mechanics
and Irritation study on Rat
Authors: Rathod Punitkumar , Lalwani Anita 
Published: February 2025

Introduction/Objective:
Agomelatine (AGT) is used for the treatment of major depressive
disorder in adults. Agomelatine is highly susceptible to first-pass metabolism, and it has less
than 5% oral bioavailability. Therapy for major depressive disorder extends for a long period and
every time, additional caregivers are required to remind and manage the timely dosing of oral medicine
to patients. In such cases, once a week, administration of agomelatine via transdermal patch
dosage form provides major patient benefits and lowers overall therapy costs.

Methods:
An agomelatine transdermal patch was prepared using the solvent evaporation method
using the LTE-S Werner Mathis AG coater and dryer. A patch was prepared using silicon adhesive
after screening different pressure-sensitive adhesives like acrylate, polyisobutylene, and silicon. To
make a crystal-free patch, the concentration of povidone k-29/32 was optimized in preliminary trials.
To deliver the drug over a 7-day period, propylene glycol monolaurate (PGML) was identified
from different penetration enhancers. Three factors optimization was carried out, like the concentration
of povidone k-29/32, the concentration of PGML, and the mixing time of the blend using the
Box Behnken design. 3D surface response curves and contour plots were derived using Design Expert
and Minitab software. From overlay plots, design spaces were identified.

Result:
The optimized AGT patch has good adhesion properties along with a desirable flux of 4.63
μg/cm2/h on human cadaver skin along with a lower residual drug. There was no impact of heat flux
studies on normal conditions, hence justifying the in-use condition of the patient population during
hot showers, baths, and saunas. AGT Patch was also non-irritating in skin irritation studies performed
on Wistar albino rats.

Conclusion:
It was concluded that agomelatine transdermal patches can be manufactured using silicon
adhesive, povidone k-29/32, and propylene glycol monolaurate for the treatment of major depressive
disorder and will be the most convenient and cost-effective therapy for the patient.
Instagram as a Tool to Improve Human Histology Learning in Medical Education: Descriptive Study
Authors: Escamilla-Sanchez Alejandro , López-Villodres Juan Antonio , Alba-Tercedor Carmen , Ortega-Jiménez María Victoria , Rius-Díaz Francisca , Sanchez-Varo Raquel , Bermúdez Diego 
Published: February 2025

Background
Student development is currently taking place in an environment governed by new technologies and social media. Some platforms, such as Instagram or X (previously known as “Twitter”), have been incorporated as additional tools for teaching and learning processes in higher education, especially in the framework of image-based applied disciplines, including radiology and pathology. Nevertheless, the role of social media in the teaching of core subjects such as histology has hardly been studied, and there are very few reports on this issue.

Objective
The aim of this work was to investigate the impact of implementing social media on the ability to learn human histology. For this purpose, a set of voluntary e-learning activities was shared on Instagram as a complement to traditional face-to-face teaching.

Methods
The proposal included questionnaires based on multiple-choice questions, descriptions of histological images, and schematic diagrams about the subject content. These activities were posted on an Instagram account only accessible by second-year medical students from the University of Malaga. In addition, students could share their own images taken during the laboratory practice and interact with their peers.

Results
Of the students enrolled in Human Histology 2, 85.6% (143/167) agreed to participate in the platform. Most of the students valued the initiative positively and considered it an adequate instrument to improve their final marks. Specifically, 68.5% (98/143) of the student body regarded the multiple-choice questions and image-based questions as the most useful activities. Interestingly, there were statistically significant differences between the marks on the final exam (without considering other evaluation activities) for students who participated in the activity compared with those who did not or barely participated in the activity (P<.001). There were no significant differences by degree of participation between the more active groups.

Conclusions
These results provide evidence that incorporating social media may be considered a useful, easy, and accessible tool to improve the learning of human histology in the context of medical degrees.
Instagram Posts Promoting Colorectal Cancer Awareness: Content Analysis of Themes and Engagement During Colorectal Cancer Awareness Month
Authors: Srivastava Aditi , Stimpson Jim P 
Published: February 2025

Abstract

Background
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, with early detection and screening being critical for reducing mortality. Social media platforms like Instagram offer a unique opportunity to raise awareness about CRC, particularly during designated awareness months. However, there is limited research on the effectiveness of CRC-related content on Instagram.

Objective
This study aims to examine how Instagram is used to raise awareness about CRC during Colorectal Cancer Awareness Month by analyzing the thematic content and engagement metrics of related posts. The research seeks to identify the prevalent themes, assess audience interaction with these messages, and highlight areas for improvement in leveraging Instagram as a tool for cancer awareness campaigns.

Methods
A total of 150 Instagram posts were collected based on their use of specific hashtags related to CRC awareness (#colorectalcancer, #colorectalcancerawareness, #colorectalcancerawarenessmonth) during March 2024. The text and images in the posts were categorized into themes such as screening and early detection, symptoms, general awareness, risk factors, individual’s experiences, representation of racial and ethnic minoritized communities, and representation of women. Engagement metrics, including the number of likes and comments, were also analyzed. Two researchers independently coded the posts, achieving high interrater reliability (Cohen κ=0.93).

Results
Organizational accounts were more active, contributing 82% (n=123) of the 150 posts, compared to 18% (n=27) from individual users. The most frequently mentioned theme was screening and early detection, which made up 37.3% (n=56) of all posts. General awareness came in second at 19.3% (n=29), and risk factors came in third at 12% (n=18). Posts about individual experiences and general awareness received the highest engagement, indicating the effectiveness of personal narratives and broad informational content. Themes related to symptoms and representation of racial and ethnic minoritized communities and women were underrepresented.

Conclusions
This study highlights the potential of Instagram as a platform for promoting CRC awareness, particularly through posts about screening and early detection and personal experiences. However, there is a need for more inclusive and diverse content to ensure a broader reach and impact.
Teacher’s Autonomy Support Role in University Psychology Class Teaching Quality
Authors: Liu Dingqiao 
Published: February 2025

This research investigates the relationship between the autonomy support afforded to teachers and class teaching. The profile of respondents includes a diverse group of teachers varying in sex, years of service, and highest educational attainment. Teachers' perceptions of autonomy support were generally positive, particularly in areas such as responsive teaching and providing rationale, although there is room for improvement in minimizing control and pressure. No significant differences were found in the perceived autonomy support based on sex, length of service, or educational attainment. The correlation analysis shows a nuanced relationship between autonomy support and class teaching.The research concludes that while overall teacher’s autonomy support do not significantly correlate with general class teaching, specific practices can influence certain dimensions of class teaching. Recommendations include improving communication, fostering a supportive environment, increasing opportunities for teacher autonomy, and providing clear rationales for decisions. These insights aim to enhance teacher’s class autonomy and contribute to creating a more effective educational environment for university students.
PURNABAKTI DALAM PERSPEKTIF KONSELING ISLAM
Authors: Jamil Yusuf M. 
Published: February 2025

Setiap orang yang bekerja sebagai Aparatur Sipil Negara, karyawan dan pekerja sesuai peraturan perundangan yang berlaku wajib menerima pada purna bakti atau pensiun dengan segala hak yang melekat padanya. Memasuki masa pensiun berarti mengakhiri masa bertugas/bekerja dan kembali menjadi warga masyarakat biasa untuk meneruskan pengabdiannya kepada keluarga dan kegiatan-kegiatan sosial masyarakat. Pada sebagian pensiunan bahwa memasuki masa purna bakti adalah sebuah kebahagiaan, namun pada sebagian lainnya bisa mengalami masalah-masalah berat seperti berkurangnya keuangan, menurunnya kesehatan, merasa kesepian dan sebagainya. Pada sebagian pensiunan yang mengalami masalah sangat mungkin yang bersangkutan dapat menangani sendiri masalahnya, namun pada sebagian lainnya dipandang perlu mendapat layanan bantuan, termasuk layanan konseling Islam. Dalam perspektif konseling Islam adalah beberapa hal yang ditawarkan, yakni: (1) memunculkan asumsi bahwa para pensiunan itu haus akan kasih sayang dan penerimaan anggota keluarga. Lalu konseling Islam harus mengakomudir dua hal ini serta mengembangkan tujuan hidup yang bermakna; (2) sebagai konselor Muslim harus mengedepankan banyak mendengar tentang masalah dan konsep hidup bermakna yang didambakan klien di hari-hari tuanya hingga menemukan kesepakatan yang bermakna; dan (3) indikator kualitas diri seseorang klien amat ditentukan oleh kualitas ketabahan dan kesabaran. Semakin tangguh seseorang menghadapi masalah, maka semakin kuat dalam mengharungi kesulitan-kesulitan hidup di hari tuanya.
EKSISTENSI MEDIA INSTAGRAM SEBAGAI UPAYA MEWUJUDKAN NILAI-NILAI DAKWAH DALAM MEMBANGUN PERADABAN ISLAM DI ACEH
Authors: Yusuf Maimun 
Published: February 2025

Instagram bagian dari media sosial yang sangat berkembang di kalangan remaja bahkan seluruh masyarakat dunia. Era digital ini menjadi suatu peluang emas dalam mensyi’arkan Islam kepada generasi bangsa, terutama bagi muda-mudi. Instagram menyajikan berbagai jenis konten, mulai dari konten positif sampai dengan konten negatif, sehingga membutuhkan perilaku yang bijak dalam menggunakan media sosial tersebut. Bagaimanapun, suatu benda akan bernilai bila berada di tangan orang yang bijak, begitu juga sebaliknya. Dalam akun instagram terdapat nilai-nilai Islam seperti nilai aqidah, syari’ah dan akhlak. Tujuan penulisan ini ingin melihat sejauh mana pendistribusian nilai-nilai syariat melalui media instagram dalam membangun peradaban syariat Islam di Aceh. Hasil penelitian menunjukkan bahwa terdapat upaya dari sebagian pengguna akun instagram untuk mensyiarkan Islam ke seluruh pelosok dunia. Upaya tersebut termasuk dalam metode dakwah di era digital. Secara menyeluruh, postingan-postingan yang terdapat pada akun instagram @majalahumdah selalu mengandung nilai-nilai dakwah, serta dipoles seindah mungkin baik tulisan, gambar dan video. Hal ini untuk meningkatkan daya minat follower dalam memahami dan mempelajari secara keseluruhan pada postingan tersebut.
ALI HASJMY : TOKOH MULTI DIMENSI DAN PENGGAGAS FAKULTAS DAKWAH PERTAMA DI INDONESIA
Authors: Zain Arifin 
Published: February 2025

Moehammad Ali Hasyim atau yang lebih dikenal dengan nama Ali Hasjmy merupakan salah seorang tokoh multi dimensi yang lahir dari Bumi Serambi Mekkah Aceh-Indonesia. Ketokohannya tidak hanya diakui di Aceh tapi juga di Indonesia bahkan di dunia terutama di negara-negara Melayu di Asia Tenggara. Ketokohannya dapat dilihat dari serangkaian ide, gagasan, pemikiran dan karya-karya yang tertuang dalam puluhan buku yang menginspirasi hingga saat ini. Penelitian ini bertujuan untuk mengetahui dan menganalisis pemikiran, ide, gagasan dan karya Ali Hajmy dalam bidang dakwah dan bagaimana ide serta gagasan tersebut diujudkan. Penelitian ini merupakan penelitian kepustakaan dengan analisis kualitatif dengan pendekatan studi tokoh. Hasil penelitian menunjukkan bahwa Ali Hasjmy dapat dikatagorikan sebagai pemikiran dan tokoh dakwah di Aceh bahkan Indonesia. Hal ini ditandai dengan buku-bukunya tentang dakwah dan yang paling spektakuler adalah dengan mendirikan Fakultas Dakwah IAIN Ar-Raniry Banda Aceh yang saat ini dikenal dengan Fakultas Dakwah dan Komunikasi UIN Ar-Raniry sebagai fakultas pertama di Indonesia.