bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of microperimetry in evaluating disease progression in age-related macular degeneration: a scoping review
Authors: Madheswaran Gopinath , Nasim Pinaz , Ballae Ganeshrao Shonraj , Raman Rajiv , Ve Ramesh S. 
Published: January 2022

Abstract
Purpose
Recent research has found variable evidence on the role of mesopic and dark-adapted scotopic microperimetry assessment in age-related macular degeneration. This scoping review summarises how mesopic and scotopic microperimetry can be used to assess disease progression in age-related macular degeneration and identifies gaps in the literature.

Methods
A population, concept, and context approach was used to develop the search strategy. Ovid MEDLINE, EMBASE, Cochrane Library, PubMed, CINAHL Plus, Web of Science, and SCOPUS databases were used to conduct the literature search. The key search terms used in the databases were age-related macular degeneration and microperimetry.

Results
Twelve studies were eligible and included in the review. All the studies (n = 12) were conducted in European countries [Germany (9), Italy (2), and the United Kingdom (1)]. The mesopic and scotopic sensitivities were measured using the Nidek scotopic microperimeter (MP1-S) (n = 6), scotopic Macular Integrity Assessment device (S-MAIA) (n = 5), and both MP1-s and S MAIA (n = 1). 83.3% (n = 10) studied (cross-sectional design) on mesopic, scotopic microperimetry and found reduced rod (scotopic) photoreceptors sensitivities compared to cone (mesopic) photoreceptors sensitivities in patients with small and reticular pseudodrusen despite having good visual acuity. Only 16.7% (n = 2) of studies followed participants with reticular drusen/large drusen for three years (longitudinal design) and found reduced scotopic over mesopic sensitivity at baseline and localized mesopic with profound scotopic sensitivity loss during follow-ups.

Conclusion
Scotopic sensitivity is a better functional indicator than mesopic sensitivity to understand early and intermediate age-related macular degeneration progression. The evidence from longitudinal studies is debatable due to the limited stimuli range of existing microperimeters, smaller sample size, and lost follow-ups.
Brief Report: Evaluating the Diagnostic Yield of Commercial Gene Panels in Autism
Authors: Ní Ghrálaigh Fiana , McCarthy Ellen , Murphy Daniel N. , Gallagher Louise , Lopez Lorna M. 
Published: January 2022

AbstractAutism is a prevalent neurodevelopmental condition, highly heterogenous in both genotype and phenotype. This communication adds to existing discussion of the heterogeneity of clinical sequencing tests, “gene panels”, marketed for application in autism. We evaluate the clinical utility of available gene panels based on existing genetic evidence. We determine that diagnostic yields of these gene panels range from 0.22% to 10.02% and gene selection for the panels is variable in relevance, here measured as percentage overlap with SFARI Gene and ranging from 15.15% to 100%. We conclude that gene panels marketed for use in autism are currently of limited clinical utility, and that sequencing with greater coverage may be more appropriate.
Creativity over time and space
Authors: Serafinelli Michel , Tabellini Guido 
Published: January 2022

AbstractCreativity is often highly concentrated in time and space, and across different domains. What explains the formation and decay of clusters of creativity? We match data on notable individuals born in Europe between the eleventh and the nineteenth centuries with historical city data. The production and attraction of creative talent is associated with city institutions that protected economic and political freedoms and promoted local autonomy. Instead, indicators of local economic conditions such as city size and real wages, do not predict creative clusters. We also show that famous creatives are spatially concentrated and clustered across disciplines, that their spatial mobility has remained stable over the centuries, and that creative clusters are persistent but less than population.
Co-evolution patterns of university patenting and technological specialization in European regions
Authors: Caviggioli Federico , Colombelli Alessandra , De Marco Antonio , Scellato Giuseppe , Ughetto Elisa 
Published: January 2022

AbstractThis paper provides novel evidence on co-evolution patterns of the technological specialization of innovation activities of firms and academic institutions located in the same European region during the years from 2003 to 2014. We exploit a novel and unique dataset merging data on EU-funded R&D projects, universities, patents, and economic region-level data for a large sample of universities and firms co-located in geographical areas at the third level of the Nomenclature of Territorial Units for Statistics (NUTS3), which correspond to a sub-regional scale of analysis. Our results indicate the presence of substantial heterogeneity across the analyzed EU regions with respect to the co-evolution of industry and academia specializations. In particular, we find that the specialization into a new technological domain is led by the local academic research system only in a few cases. We also document that a number of factors, at both the university and region levels, are associated with convergent or divergent processes in the relative specialization of the innovation activities carried out by firms and universities co-located in the same region.
Using student feedback about the learning environment as a starting point for co-construction
Authors: Aldridge Jill M. , Bianchet Silvana 
Published: January 2022

AbstractThe context in which learning takes place, or learning environment, is pivotal to a positive learning experience for students. Although numerous studies have established strong links between a positive learning environment and a range of student outcomes, far less research has examined how teachers might establish such an environment. Amidst growing acknowledgment that opportunities for the co-construction of learning and assessment design could provide a means of developing a more positive learning environment, this case study examined one such journey. Using a case study approach, we argue that student feedback involving a learning environment survey provides a valuable starting point for including students in co-construction and classroom improvement. Our findings indicate that teachers can improve the learning environment by involving students in meaningful co-construction through open tasks.
Rewriting the History of Connexive Logic
Authors: Lenzen Wolfgang 
Published: January 2022

AbstractThe “official” history of connexive logic was written in 2012 by Storrs McCall who argued that connexive logic was founded by ancient logicians like Aristotle, Chrysippus, and Boethius; that it was further developed by medieval logicians like Abelard, Kilwardby, and Paul of Venice; and that it was rediscovered in the 19th and twentieth century by Lewis Carroll, Hugh MacColl, Frank P. Ramsey, and Everett J. Nelson. From 1960 onwards, connexive logic was finally transformed into non-classical calculi which partly concur with systems of relevance logic and paraconsistent logic. In this paper it will be argued that McCall’s historical analysis is fundamentally mistaken since it doesn’t take into account two versions of connexivism. While “humble” connexivism maintains that connexive properties (like the condition that no proposition implies its own negation) only apply to “normal” (e.g., self-consistent) antecedents, “hardcore” connexivism insists that they also hold for “abnormal” propositions. It is shown that the overwhelming majority of the forerunners of connexive logic were only “humble” connexivists. Their ideas concerning (“humbly”) connexive implication don’t give rise, however, to anything like a non-classical logic.
A General Theory of Location Based on the Notion of Entire Location
Authors: Correia Fabrice 
Published: January 2022

AbstractIt would be a good thing to have at our disposal a general theory of location that is neutral with respect to (i.e. that does not rule out or entail) (i) the view that some objects have more than one exact location, (ii) the view that some objects are located without having an exact location, and (iii) the view that some objects are “spanners”—where a spanner is an object exactly located at a region that has proper parts but which has no proper part exactly located at a proper part of the region. As far as I know, no theory of location that can be found in the literature has this feature. I put forward a new theory that does—or so I argue. The theory takes as its sole locational primitive the notion ofbeing entirely located at.
Tumor load rather than contrast enhancement is associated with the visual function of children and adolescents with optic pathway glioma – a retrospective Magnetic Resonance Imaging study
Authors: Kilian Anna , Aigner Annette , Simon Michèle , Salchow Daniel J. , Potratz Cornelia , Thomale Ulrich-Wilhelm , Hernáiz Driever Pablo , Tietze Anna 
Published: January 2022

Abstract
Introduction
Optic pathway gliomas are often asymptomatic tumors occurring in children with neurofibromatosis type 1 (NF1 + OPG) or sporadically (spOPG). Treatment is usually prompted by visual loss and/or tumor progression on MRI. The aim of this study was to investigate the relationship between visual acuity (VA), tumor growth, and contrast enhancement to provide more distinct indications for the administration of gadolinium-based contrast agents.

Methods
Tumor load was retrospectively measured and enhancement semi-quantitatively scored on 298 MRIs of 35 patients (63% NF1 + OPG). Spearman rank correlation between tumor load and enhancement was calculated and a linear mixed model used to examine the influence of tumor load and enhancement on corresponding VA tests (LogMAR).

Results
The optic nerve width in NF1 + OPGs was strongly associated with VA (regression coefficient 0.75; confidence interval 0.61—0.88), but weakly with enhancement (0.06; −0.04—0.15). In spOPGs, tumor volume and optic nerve width were more relevant (0.31; −0.19—0.81 and 0.39; 0.05—0.73) than enhancement (0.09; −0.09—0.27).

Conclusions
Tumor load measures may be more relevant for the surveillance of optic pathway gliomas than enhancement, given that VA is the relevant outcome parameter. Regular contrast administration should therefore be questioned in these patients.
When Do Voters Respond to Campaign Finance Disclosure? Evidence from Multiple Election Types
Authors: Robinson Thomas S. 
Published: January 2022

AbstractIn recent American elections political candidates have actively emphasized features of their fundraising profiles when campaigning. Yet, surprisingly, we know comparatively little about how financial information affects vote choice specifically, whether effects differ across types of election, and how robust any effects are to other relevant political signals. Using a series of conjoint experiment designs, I compare the effects of campaigns’ financial profiles on vote choice across direct democratic and representative elections, randomizing subjects’ exposure to additional political cues. I find that while the financial profile of candidates can affect vote choice, these effects are drowned out by non-financial signals. In ballot initiative races, the explicit policy focus of the election appears to swamp any effect of financial information. This paper is the first to explore the comparative effects of financial disclosure across election type, contributing to our understanding of how different heuristics interact across electoral contexts.
Inhibition of the urea-urease reaction by the components of the zeolite imidazole frameworks-8 and the formation of urease-zinc-imidazole hybrid compound
Authors: Német Norbert , Miele Ylenia , Shuszter Gábor , Tóth Eszter L. , Maróti János Endre , Szabó Péter János , Rossi Federico , Lagzi István 
Published: January 2022

AbstractIn the past decade, much effort has been devoted to using chemical clock-type reactions in material design and driving the self-assembly of various building blocks. Urea-urease enzymatic reaction has chemical pH clock behavior in an unbuffered medium, in which the induction time and the final pH can be programmed by the concentrations of the reagents. The urea-urease reaction can offer a new alternative in material synthesis, where the pH and its course in time are crucial factors in the synthesis. However, before using it in any synthesis method, it is important to investigate the possible effects of the reagents on the enzymatic reaction. Here we investigate the effect of the reagents of the zeolite imidazole framework-8 (zinc ions and 2-methylimidazole) on the urea-urease reaction. We have chosen the zeolite imidazole framework-8 because its formation serves as a model reaction for the formation of other metal–organic frameworks. We found that, besides the inhibition effect of the zinc ions which is well-known in the literature, 2-methylimidazole inhibits the enzymatic reaction as well. In addition to the observed inhibition effect, we report the formation of a hybrid urease-zinc-2-methylimidazole hybrid material. To support the inhibition effect, we developed a kinetic model which reproduced qualitatively the experimentally observed kinetic curves.
The Revival of Business Groups’ Risk Sharing: Evidence from Japanese Real Estate Investment Trust Market
Authors: Mori Masaki , Ong Seow Eng , Ooi Joseph T. L. 
Published: January 2022

AbstractWe examine the business groups’ risk-sharing hypothesis in the Japanese Real Estate Investment Trust (REIT) market in which the unique external management system seems to be reinforcing power relationships among firms affiliated with the modern Japanese business groups, called keiretsu. We find that REITs whose sponsors belong to one of the keiretsu groups (keiretsu REITs) have significantly lower volatility of profitability than REITs whose sponsors do not belong to the keiretsu groups (non-keiretsu REITs). There is no significant difference in profitability between keiretsu REITs and non-keiretsu REITs, controlling for firm and property characteristics. The abnormal portion of the profitability unexplained by firm characteristics is also significantly lower with keiretsu REITs. We also find that the keiretsu affiliation reduces the systematic volatility of affiliated REITs, while such an effect is not observed with the idiosyncratic volatility, suggesting that the risk-sharing effect may be beneficial for the value of REITs. Using the difference-in-differences design with propensity score matching, we find that the negative impact of the Great East Japan Earthquake on the profitability was significantly smaller with keiretsu REITs than with non-keiretsu REITs. Keiretsu REITs were also able to stabilize their capital structure by shifting some short-term debts to long-term debts without increasing the cost of loans under the uncertain situation caused by the Earthquake. Keiretsu REITs were able to borrow money from their affiliated group banks even right after the earthquake, while non-keiretsu REITs seem to have struggled to secure loans from those banks.
Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer
Authors: Fernández Montes A. , Élez E. , Vivancos A. , Martínez N. , González P. , Covela M. , de la Cámara J. , Cousillas A. , Méndez J. C. , Graña B. , Aranda E. 
Published: January 2022

Abstract
Purpose
Some patients with histologically confirmed primary mCRC and mutated RAS reported undetectable RAS mutant clones in plasma after receiving anti-VEGF treatment. The aim was to prospectively assess it with its potential therapeutic implications.

Methods
RAS mutant genes in solid biopsy (before first-line treatment: FOLFOX/CAPOX + bevacizumab) were compared in liquid biopsy (before second-line treatment: panitumumab + FOLFIRI), using Idylla™ system. Discordant results between solid/liquid biopsies were assessed by the next-generation sequencing (NGS) test (solid/liquid biopsies).

Results
Twenty-three patients were assessed (seven had RAS mutant discrepancies between solid/liquid biopsies). The NGS test confirmed that 3/23 (13%) patients had undetectable RAS mutant clones in liquid biopsy and 3/23 (13%) presented discrepancies in solid biopsy (Idylla™ system vs. NGS test).

Conclusion
Thirteen percentage of patients had undetectable RAS mutant clones in liquid biopsy after first-line treatment. However, some discrepancies between solid and liquid biopsies have been observed. These results suggest a need to improve accuracy of RAS analyses, especially in solid biopsies.
Spatial Heterogeneity in Prey Availability, Feeding Success, and Dietary Selectivity for the Threatened Longfin Smelt
Authors: Barros Arthur , Hobbs James A. , Willmes Malte , Parker Christina M. , Bisson Micah , Fangue Nann A. , Rypel Andrew L. , Lewis Levi S. 
Published: January 2022

AbstractFood availability is a key determinant of the nursery value of a given habitat for larval and juvenile fishes. Growth, survival, and recruitment success are often inter-correlated and influenced by prey availability and associated feeding success. This is likely true for the threatened population of Longfin Smelt (Spirinchus thaleichthys) in the San Francisco Estuary (SFE) which has collapsed in recent decades along with its preferred prey. In years with high precipitation and freshwater outflow, larval Longfin Smelt are found in shallow wetland habitats throughout the SFE, but variation in the availability of food and feeding success in these habitats remains unexplored. To examine spatial variation in the trophic value of different rearing habitats, we quantified variation in prey availability, feeding success, and prey selection for larval and juvenile Longfin Smelt captured in restored tidal marshes, sloughs, and open-water habitats in the northern and southern SFE. Prey abundance varied spatially, with densities approximately tenfold greater in southern sloughs and restored tidal ponds relative to northern and open-water habitats. Feeding success of larval Longfin Smelt was positively correlated with both fish length and prey density. Larval Longfin Smelt fed selectively on the copepodEurytemora affinis, with larger individuals (> 25 mm total length) exhibiting an ontogenetic diet shift to larger mysid shrimps. Our results suggest that wetland habitats across the SFE vary greatly in their trophic value, with previously unexplored habitats exhibiting the highest densities of prey and the highest foraging success for larval Longfin Smelt.
Do Speed and Proximity Affect Human-Robot Collaboration with an Industrial Robot Arm?
Authors: Story Matthew , Webb Phil , Fletcher Sarah R. , Tang Gilbert , Jaksic Cyril , Carberry Jon 
Published: January 2022

AbstractCurrent guidelines for Human-Robot Collaboration (HRC) allow a person to be within the working area of an industrial robot arm whilst maintaining their physical safety. However, research into increasing automation and social robotics have shown that attributes in the robot, such as speed and proximity setting, can influence a person’s workload and trust. Despite this, studies into how an industrial robot arm’s attributes affect a person during HRC are limited and require further development. Therefore, a study was proposed to assess the impact of robot’s speed and proximity setting on a person’s workload and trust during an HRC task. Eighty-three participants from Cranfield University and the ASK Centre, BAE Systems Samlesbury, completed a task in collaboration with a UR5 industrial robot arm running at different speeds and proximity settings, workload and trust were measured after each run. Workload was found to be positively related to speed but not significantly related to proximity setting. Significant interaction was not found for trust with speed or proximity setting. This study showed that even when operating within current safety guidelines, an industrial robot can affect a person’s workload. The lack of significant interaction with trust was attributed to the robot’s relatively small size and high success rate, and therefore may have an influence in larger industrial robots. As workload and trust can have a significant impact on a person’s performance and satisfaction, it is key to understand this relationship early in the development and design of collaborative work cells to ensure safe and high productivity.
Effects of an 8-Week Mindfulness Course on Affective Polarization
Authors: Simonsson Otto , Bazin Olivier , Fisher Stephen D. , Goldberg Simon B. 
Published: January 2022

Abstract
Objectives
The European Union Brexit referendum has split the British electorate into two camps, with high levels of affective polarization between those who affiliate with the Remain side (Remainers) and the Leave side (Leavers) of the debate. Previous research has shown that a brief meditation intervention can reduce affective polarization, but no study has thus far investigated the effects of an 8-week mindfulness program on affective polarization. This is what will be examined in this study.

Methods
The present study used a randomized waitlist control design (n = 177) with a 1-month post-intervention follow-up to investigate whether an 8-week mindfulness program delivered online would have an effect on affective polarization among Remainers and Leavers.

Results
Results showed significantly greater reductions in affective polarization over time for participants in the mindfulness condition relative to participants in the waitlist control condition (time X group B =  − 0.087, p = .024).

Conclusions
Taken together, the findings highlight the potential of mindfulness training as a means to reduce intergroup biases in political contexts.

Trial Registration
Preregistered on the Open Science Framework at https://osf.io/px8m2.