bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incident review in radiation oncology
Authors: Arnold Anthony , Ward Iain , Gandhidasan Senthilkumar 
Published: March 2022

AbstractBy its very nature, radiation oncology is a complex, multi‐profession dynamic modality of cancer treatment. There are multiple steps with many handovers of work and many opportunities for patient safety to be compromised. Patient safety events can manifest as either actual incidents or near miss/close call events. Reporting and learning from these events is key to quality improvement and patient safety. In this paper, we aim to provide an overview of radiation oncology incident reporting and learning systems. We review the importance of the use of a standardized taxonomy and classification that is specific to radiation oncology workflow, the international systems in current use and the current reporting requirements in Australia and New Zealand. Equally important is the culture that exists alongside the incident learning system. A just culture, where support for reporting exists and there is an adaptive responsive environment to learn and improve patient safety. The incident learning and patient safety system requires constant effort to make it a success. We describe potential measures of safety culture and of relative patient safety and recommend their routine use. We offer this review to stimulate the effort towards a binational voluntary incident learning system, a key pillar for the improvement in patient safety in radiation oncology.
Part 1: Imaging findings of common immune checkpoint inhibitor‐related adverse effects
Authors: Noë Geertje , Cardin Anthony , Lasocki Arian 
Published: March 2022

AbstractOver the last decade or so, immunotherapy and in particular immune checkpoint inhibitors have become common in the treatment of numerous cancers and have revolutionised oncology. The unique mechanisms of these agents has resulted in novel tumour response patterns and also new drug‐related toxicities, both of which can have specific findings on imaging. The widespread and increasing use of these agents means these findings are now encountered across many radiology practices beyond just specialist oncology units. This pictorial essay aims to describe and illustrate imaging findings associated with common and important immune‐related adverse events as a result of treatment with immune checkpoint inhibitors.
Preclinical studies and clinical trials on mesenchymal stem cell therapy for knee osteoarthritis: A systematic review on models and cell doses
Authors: Wang Guishan , Xing Dan , Liu Wei , Zhu Yuanyuan , Liu Haifeng , Yan Lei , Fan Kenan , Liu Peidong , Yu Baofeng , Li Jiao Jiao , Wang Bin 
Published: March 2022

AbstractAimTo provide a systematic analysis of the study design in knee osteoarthritis (OA) preclinical studies, focusing on the characteristics of animal models and cell doses, and to compare these to the characteristics of clinical trials using mesenchymal stem cells (MSCs) for the treatment of knee OA.MethodA systematic and comprehensive search was conducted using the PubMed, Web of Science, Ovid, and Embase electronic databases for research papers published in 2009‐2020 on testing MSC treatment in OA animal models. The PubMed database and ClinicalTrials.gov website were used to search for published studies reporting clinical trials of MSC therapy for knee OA.ResultsIn total, 9234 articles and two additional records were retrieved, of which 120 studies comprising preclinical and clinical studies were included for analysis. Among the preclinical studies, rats were the most commonly used species for modeling knee OA, and anterior cruciate ligament transection was the most commonly used method for inducing OA. There was a correlation between the cell dose and body weight of the animal. In clinical trials, there was large variation in the dose of MSCs used to treat knee OA, ranging from 1 × 106 to 200 × 106 cells with an average of 37.91 × 106 cells.ConclusionMesenchymal stem cells have shown great potential in improving pain relief and tissue protection in both preclinical and clinical studies of knee OA. Further high‐quality preclinical and clinical studies are needed to explore the dose effectiveness relationship of MSC therapy and to translate the findings from preclinical studies to humans.
Epidemiologic evaluation of pleurisy diagnosed by surgical pleural biopsy using data from a nationwide administrative database
Authors: Hara Kanako , Yamasaki Kei , Tahara Masahiro , Ikegami Hiroaki , Nishida Chinatsu , Muramutsu Keiji , Fujino Yoshihisa , Matsuda Shinya , Fushimi Kiyohide , Mukae Hiroshi , Yatera Kazuhiro 
Published: March 2022

AbstractBackgroundPleural biopsies for investigating the causes of pleurisy are performed through modalities including needle biopsies, local anesthetic thoracoscopic procedures, and surgery (video‐assisted thoracoscopic surgery and open thoracotomy). To date, there have been no large‐scale nationwide epidemiological studies regarding pleurisy diagnosed via surgical pleural biopsy. This study examined the epidemiology of pleurisy diagnosed via surgical pleural biopsy in a Japanese nationwide administrative database.MethodsWe evaluated Japanese Diagnosis Procedure Combination data of 24 173 patients who underwent video‐assisted thoracoscopic surgery or open thoracotomy and received a diagnosis of pleurisy between April 2014 and March 2020. In addition to pleurisy diagnoses, the patients' clinical information, including age, sex, smoking status (pack‐years), dyspnea grade, length of in‐hospital stay, and comorbidities, were extracted from the dataset.ResultsThis study included data from 1699 patients. The most frequent causes of pleurisy were neoplastic diseases (55.9%; malignant mesothelioma 22.5%, lung cancer 15.7%, lymphoma 2.5%), followed by infectious diseases (24.0%; tuberculosis 16.2%, parapneumonic pleural effusion 3.6%, empyema 3.5%, nontuberculous mycobacteriosis 0.5%), collagen vascular diseases (2.8%; rheumatoid arthritis 1.3%, immunoglobulin G4‐related diseases 0.7%, systemic lupus erythematosus 0.3%), and paragonimiasis (0.1%).ConclusionsNeoplastic diseases, including malignant mesothelioma and lung cancer, were frequently and accurately diagnosed as pleurisy via surgical pleural biopsy. The next leading cause was infectious diseases such as mycobacterial infections. Physicians should consider performing surgical biopsy in light of the knowledge regarding the etiology of pleurisy when a definitive diagnosis cannot be made via needle pleural biopsy.
Attachment insecurity partially mediates the relationship between childhood trauma and depression severity in bipolar disorder
Authors: Wrobel Anna L. , Russell Samantha E. , Jayasinghe Anuradhi , Lotfaliany Mojtaba , Turner Alyna , Dean Olivia M. , Cotton Sue M. , Diaz‐Byrd Claudia , Yocum Anastasia K. , Duval Elizabeth R. , Ehrlich Tobin J. , Marshall David F. , Berk Michael , McInnis Melvin G. 
Published: March 2022

AbstractBackgroundChildhood trauma is associated with greater depression severity among individuals with bipolar disorder. However, the mechanisms that explain the link between childhood trauma and depression severity in bipolar disorder remain poorly understood. The mediational role of attachment insecurity in childhood and adulthood was assessed in the current study.MethodsParticipants with bipolar disorder (N = 143) completed measures of childhood trauma (Childhood Trauma Questionnaire), attachment insecurity (Experiences in Close Relationships Scale) and depression severity (Hamilton Depression Rating Scale) as part of the Prechter Longitudinal Study of Bipolar Disorder. A sequential mediation model was tested using path analysis: the direct and indirect effects of childhood trauma on depression severity with attachment insecurity (attachment anxiety and avoidance) in childhood (mother and father) and adulthood (partner) as mediators were estimated.ResultsThe final path model demonstrated an excellent fit to the data (comparative fit index = 0.996; root mean square error of approximation = 0.021 [90% confidence interval = 0.000–0.073]). Supporting the hypothesised sequential mediation model, maternal attachment anxiety in childhood and romantic attachment avoidance in adulthood partially mediated the relationship between childhood trauma and depression severity; this effect accounted for 12% of the total effect of childhood trauma on depression severity.ConclusionAttachment insecurity in childhood and adulthood form part of the complex mechanism informing why people with bipolar disorder who have a history of childhood trauma experience greater depression severity. Addressing attachment insecurity represents a valuable psychotherapeutic treatment target for bipolar disorder.
Extreme phenotypic diversity in operant response to intravenous cocaine or saline infusion in the hybrid mouse diversity panel
Authors: Bagley Jared R. , Khan Arshad H. , Smith Desmond J. , Jentsch James D. 
Published: March 2022

AbstractCocaine self‐administration is a complexly determined trait, with a substantial proportion of individual differences being determined by genetic variation. However, the relevant genetic variants that drive heritable differences in cocaine use remain undiscovered. Cocaine intravenous self‐administration (IVSA) procedures in laboratory animals provide opportunities to prospectively investigate neurogenetic influences on the acquisition of voluntary cocaine use. Here, we provide information on cocaine (or saline—as a control) IVSA in 84 members of the hybrid mouse diversity panel (HMDP), an array of genetically distinct classical or recombinant inbred strains. We found cocaine IVSA to be substantially heritable in this population, with strain‐level intake ranging for near 0 to >25 mg/kg/session. Though saline IVSA was also found to be heritable, a modest genetic correlation between cocaine and saline IVSA indicates that operant responding for the cocaine reinforcer was influenced, at least in part, by unique genetic variants. Genome‐wide association studies (GWAS) of infusions earned in cocaine and saline groups revealed significant quantitative trait loci (QTL) on Chromosomes 3 and 14 for cocaine, but not saline, IVSA. Positional candidates were further prioritized through use of bulk RNA sequencing data that revealed genes with cis‐eQTL and genetic correlation to number of infusions. Additionally, these data identify reference strains with extreme cocaine IVSA phenotypes, revealing them as polygenic models of risk and resilience to cocaine reinforcement. This work is part of an ongoing effort to characterize genetic variation that moderates cocaine IVSA that may, in turn, provide a more comprehensive understanding of cocaine risk genetics and neurobiology.
Editorial: a paradigm shift in NUDT15 assessment—towards predictive and personalised medicine in Crohn’s disease?
Authors: Banerjee Rupa , Raghunathan Nalini 
Published: March 2022

LINKED CONTENTThis article is linked to Kim et al papers. To view these articles, visit https://doi.org/10.1111/apt.16769 and https://doi.org/10.1111/apt.16813
Corporate social responsibility decoupling in developing countries: Current research and a future agenda
Authors: Khan Majid , Lockhart James 
Published: March 2022

AbstractThe aim of this paper is to present an institutionally grounded account of CSR decoupling in developing countries. Businesses in developing countries face institutional conditions significantly different to that in developed countries. As a result of these differences, there is an increasing demand on organizations in developing countries to comply with what are observed to be diffuse CSR standards—to which they thereby engage by decoupling. These observations result in the need to re‐examine the classic argument of decoupling and produce a more effective understanding of why and how CSR decoupling exists in such contexts. Little is known about the consequences of decoupling for organizations and society at large. We provide examples of decoupling in the developing world and present a comprehensive agenda for future research that explains why decoupling is pervasive and rapid change is, sadly, unlikely.
Changes in business students' value orientations after the COVID‐19 outbreak: An exploration
Authors: Town Sophia , Weber James , Nagy Noémi 
Published: March 2022

AbstractThe values people hold tend to be relatively enduring. An important exception appears to be values adaptation in response to major, life‐altering situations. Major events can act as triggers for people to adapt their values based on the new context. In particular, collective traumas—such as the COVID‐19 pandemic—may incite immediate values change. The aim of the current paper is to compare business school students' value orientations before and after the COVID‐19 global pandemic outbreak. We investigated responses from two comparable samples of business students: one surveyed before and one surveyed after the outbreak of the COVID‐19 pandemic. The subjects' individual value orientations were aggregated and analyzed by comparing the distribution of the first group's pre‐COVID‐19 outbreak responses with the second group's post‐COVID‐19 outbreak responses regarding the importance given to values in the Rokeach Values Survey. We further explored specific demographic differences in personal versus social orientations and competence versus moral orientations for our samples. Results confirm differences in business school students' pre‐COVID‐19 outbreak versus post‐COVID‐19 outbreak value orientations, with the post‐COVID‐19 outbreak sample reporting greater attention to social values, as predicted, and competence values, not as predicted. Implications of our findings are discussed.
Exploring the interplay between socioeconomic status and reading achievement: An expectancy‐value perspective
Authors: Yeung Susanna S. S. , King Ronnel B. , Nalipay Ma. Jenina N. , Cai Yuyang 
Published: March 2022

BackgroundSocioeconomic status (SES) and motivation are both important predictors of student achievement. However, most studies have investigated these factors separately, and very few have looked into the interplay between SES and motivation as determinants of student reading achievement.AimsWe intend to bridge this gap by examining a model of SES predicting reading achievement through motivation (i.e., expectancy and value) at both student and school levels.SampleWe used the data from the Programme for International Student Assessment (PISA) 2018 of 26,281 students from four regions in Greater China (Mainland China, Hong Kong, Macau, and Taipei).MethodsWe used multi‐group multilevel path analysis to test whether SES would predict reading achievement mediated by expectancy and value in student and school levels across four regions, with gender as a covariate.ResultsResults showed that at the student level, SES significantly predicted reading achievement indirectly through both expectancy and value across four regions. At the school level, the relationship between school SES and school reading achievement was mostly direct.ConclusionThe study was able to demonstrate the motivational gap as a pathway in which economic inequality can contribute to students’ reading achievement gap.
Epidermolysis bullosa aquisita following immune-checkpoint inhibitor treatment for metastatic melanoma
Authors: O'Connor Jane , Zhang Shuai , Galante Joao R. , Mee John , Semkova Kristina , Parkar Rosemeen , Groves Richard 
Published: March 2022

AbstractA case of epidermolysis bullosa aquisita following immunotherapy for melanoma. This adds to the repertoire of subepidermal blistering disorders documented following immune checkpoint therapy.
Ovarian response to follicle‐stimulating hormone in women with polycystic ovary syndrome is diminished compared to ovulatory controls
Authors: Harrison Tracy N. H. , Chang R. Jeffrey 
Published: March 2022

AbstractObjectiveThe mechanisms underlying ovarian dysfunction in polycystic ovary syndrome (PCOS) have not been definitively established. Our objective was to perform a detailed examination of ovarian responses to recombinant follicle‐stimulating hormone (rFSH) in women with PCOS and controls.DesignThis prospective, crossover, dose–response study included three rFSH stimulation periods. Each stimulation period involved three consecutive, daily, subcutaneous injections of rFSH administered at a single dose. Low, medium and high rFSH doses were weight‐adjusted, corresponding to 0.5, 1.1 and 2.2 IU/kg/d, respectively. Stimulation periods occurred in randomized order and were separated by 8‐week washouts.PatientsThirty participants (8 PCOS and 22 controls) were studied. PCOS was defined by oligomenorrhea and clinical or biochemical androgen excess, excluding other aetiologies of ovulatory dysfunction.MeasurementsBlood samples were obtained for hormone measurements before and 24 h after each rFSH injection.ResultsParticipants with PCOS had significantly greater body mass index, antral follicle count and circulating testosterone, anti‐mullerian hormone (AMH) and luteinizing hormone concentrations compared with controls participants. Baseline estradiol (E2) concentrations were similar in both groups. At the lowest dose of rFSH, PCOS participants did not demonstrate E2 increments, whereas a significant increase occurred in controls. rFSH‐induced E2 production per follicle was significantly reduced in PCOS participants compared with controls at all rFSH doses. Increasing T and decreasing AMH concentrations were associated with augmented E2 production per follicle.CoONCLUSIONSWomen with PCOS exhibited diminished initial E2 responses to rFSH compared with controls. These findings suggest that the mechanism of anovulation in PCOS may involve altered ovarian response to gonadotropins.
On the economics of meat processing, livestock queuing, and worker safety
Authors: Larue Bruno 
Published: March 2022

AbstractMeat processing plants use inputs in fixed proportions, but these proportions vary with plant size. Shocks to the supply of labor and livestock induce allocative inefficiency, output reductions, and higher unit costs of production. Both labor conflicts and the pandemic caused long labor shortages resulting in unused capacity and large livestock queues. Industry concentration and vertical integration can mitigate some of these problems by internalizing queuing costs and by reallocating workers across plants. Daily shocks make plants operate with either too many workers or too many live animals. Larger plants choose to be labor‐constrained more frequently, creating a trade‐off between wages and safety for workers.
Parallel model exploration for tumor treatment simulations
Authors: Akasiadis Charilaos , Ponce‐de‐Leon Miguel , Montagud Arnau , Michelioudakis Evangelos , Atsidakou Alexia , Alevizos Elias , Artikis Alexander , Valencia Alfonso , Paliouras Georgios 
Published: March 2022

AbstractComputational systems and methods are often being used in biological research, including the understanding of cancer and the development of treatments. Simulations of tumor growth and its response to different drugs are of particular importance, but also challenging complexity. The main challenges are first to calibrate the simulators so as to reproduce real‐world cases, and second, to search for specific values of the parameter space concerning effective drug treatments. In this work, we combine a multi‐scale simulator for tumor cell growth and a genetic algorithm (GA) as a heuristic search method for finding good parameter configurations in reasonable time. The two modules are integrated into a single workflow that can be executed in parallel on high performance computing infrastructures. In effect, the GA is used to calibrate the simulator, and then to explore different drug delivery schemes. Among these schemes, we aim to find those that minimize tumor cell size and the probability of emergence of drug resistant cells in the future. Experimental results illustrate the effectiveness and computational efficiency of the approach.
The roles of polymer relaxation phenomena, aqueous dye solubility and the physical properties of water in the mechanism of adsorption of a disperse dye on poly(ethylene terephthalate) fibres: Part 1 polymer relaxation phenomena
Authors: Burkinshaw Stephen M. , Liu Kangsheng 
Published: March 2022

AbstractTo investigate the contributions of polymer relaxation phenomena to the mechanism of disperse dye adsorption on poly(ethylene terephthalate) fibres, a commercial grade dye was applied to poly(ethylene terephthalate) fabric at temperatures between 30°C and 130°C. Three regions of temperature‐dependent dyeing behaviour were identified, in which the promotional effect imparted by increasing dyeing temperature varied, depending on whether dyeing had been carried out at temperatures that were below, within or above the polymer's glass transition temperature, Tg, namely < 65°C, between 65°C and 110°C and between 110°C and 130°C, respectively. When experimentally determined colour strength data points (log 1/fk) were fitted to plots of polymer structural relaxation (log aT) calculated using the Williams, Landel and Ferry equation as a function of (T − Tg), three different levels of correspondence were achieved which paralleled the observed three regions of temperature‐dependent dye uptake. The adsorption of the commercial disperse dye on the poly(ethylene terephthalate) fibre therefore concurs with the free volume model of dye diffusion insofar as the diffusional behaviour of the dye is related to the relaxation time of the molecular motions occurring within the poly(ethylene terephthalate) polymer. The finding that the poly(ethylene terephthalate) substrate's glass transition extends over a broad range of temperature upto ~110°C explains why elevated dyeing temperatures in the region of 130/140°C must be used in High Temperature dyeing processes, and also, why ~75% of uptake of the commercial disperse dye on the poly(ethylene terephthalate) fabric occurs over the very narrow 20‐30°C critical temperature range between 110 and 130°C/140°C.
Identifying predictors of species diversity to guide designation of marine protected areas
Authors: Hodge Brooke C. , Pendleton Daniel E. , Ganley Laura C. , O'Brien Orfhlaith , Kraus Scott D. , Quintana‐Rizzo Ester , Redfern Jessica V. 
Published: March 2022

AbstractMarine Protected Areas (MPAs) are a widely‐used tool for conserving biodiversity. Features that support marine mammal foraging have been suggested as important components to include in MPAs, but research is needed to understand the relationship between these features and diversity. For example, the Northeast Canyons and Seamounts Marine National Monument represents an area known to support marine mammal foraging and was designated to protect an area of high marine mammal diversity. However, no comparisons have been made between marine mammal diversity in the Monument and other areas. We used 3,174,167 km of survey effort and 189,175 sightings to assess alpha and beta diversity in the Monument and 500 randomly selected sites along the east coast of the United States. We used linear models to relate diversity to variables that represent marine mammal foraging areas. Our analyses showed a gradient of higher to lower diversity from north to south and that the shelf‐edge, canyons, and areas of likely upwelling support high diversity. We also found that the Monument protects a diverse and unique marine mammal community. Our analyses contribute to efforts to designate MPAs to conserve habitat that is important for protecting species by identifying drivers of biodiversity and potential sites for protecting 30% of the planet by 2030.