bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer Chemotherapy via Natural Bioactive Compounds
Authors: Pathak Kalyani , Pathak Manash P. , Saikia Riya , Gogoi Urvashee , Sahariah Jon J. , Zothantluanga James H. , Samanta Abhishek , Das Aparoop 
Published: April 2022

Background:
Cancer-induced mortality is increasingly prevalent globally, which skyrocketed
the necessity to discover new/novel, safe and effective anticancer drugs. Cancer is characterized
by the continuous multiplication of cells in the human, which is unable to control. Scientific research
is drawing its attention toward naturally-derived bioactive compounds as they have fewer side effects
compared to the current synthetic drugs used for chemotherapy.

Objective:
Drugs isolated from natural sources and their role in the manipulation of epigenetic markers
in cancer are discussed briefly in this review article.

Methods:
With advancing medicinal plant biotechnology and microbiology in the past century, several
anticancer phytomedicines were developed. Modern pharmacopeia contains at least 25% herbal-based
remedies, including clinically used anticancer drugs. These drugs mainly include the podophyllotoxin
derivatives vinca alkaloids, curcumin, mistletoe plant extracts, taxanes, camptothecin, combretastatin,
and colchicine artesunate, homoharringtonine, ellipticine, roscovitine, maytansine, tapsigargin,and
bruceantin.

Results:
Compounds (psammaplin, didemnin, dolastin, ecteinascidin, and halichondrin) isolated from
marine sources and animals such as microalgae, cyanobacteria, heterotrophic bacteria, invertebrates.
They have been evaluated for their anticancer activity on cells and experimental animal models and
used chemotherapy.Drug-induced manipulation of epigenetic markers plays an important role in the
treatment of cancer.

Conclusion:
The development of a new drug from isolated bioactive compounds of plant sources has
been a feasible way to lower the toxicity and increase their effectiveness against cancer. Potential anticancer
therapeutic leads obtained from various ethnomedicinal plants, foods, marine, and microorganisms
are showing effective yet realistically safe pharmacological activity. This review will highlight
important plant-based bioactive compounds like curcumin, stilbenes, terpenes, other polyphenolic
phyto-compounds, and structurally related families that are used to prevent/ ameliorate cancer. However,
a contribution from all possible fields of science is still a prerequisite for discovering safe and
effective anticancer drugs.
Metformin Sensitizes Cisplatin-induced Apoptosis Through Regulating
Nucleotide Excision Repair Pathway In Cisplatin-resistant Human Lung
Cancer Cells
Authors: Li Haiwen , Yang Donghong , Xu Zumin , Yang Liu , Lin Jiong , Cai Jingyi , Yang Li 
Published: April 2022

Background:
Lung cancer is a leading cause of cancer death globally. Platinum-based chemotherapeutic
medications are essential for treating advanced NSCLC, despite that drug resistance severely
limits its effectiveness.

Objective:
In this study, we investigated the cytotoxic effect of metformin on cisplatin-resistant NSCLC
cells (A549/DDP) and its potential mechanisms.

Methods:
Anti-lung cancer efficacy of metformin, cisplatin, and metformin combined with cisplatin was
examined in A549 and A549/DDP cells. The cell counting kit-8 (CCK-8) assay was applied for measuring
cell proliferation. CalcuSyn software was used to calculate the combination index and estimate the
synergistic effect of metformin and cisplatin on cell proliferation. The cell apoptosis was analyzed by
flow cytometry and the expression of apoptosis-related proteins, Bcl-2, Bax and caspase-3 were analyzed
using Western blot. Futhermore, the expression of key nucleotide excision repair (NER) proteins,
ERCC1, XPF, and XPA, was also analyzed using Western blot.

Results:
We found that metformin had dose-dependent antiproliferative effects on A549/DDP and A549
cells. The combination of metformin and cisplatin had higher effectiveness in inhibiting A549/DDP and
A549 cell growth than either of the two drugs alone. Flow cytometry analysis indicated that the combined
treatment could cause more cell apoptosis than the single-drug treatment. Consistently, the combined
treatment decreased the expression of Bcl-2 protein and elevated the expression of Bax, and cleaved
caspase-3 proteins. The expression level of ERCC1, XPF, and XPA proteins were lower in the combined
treatment than in either of metformin and cisplatin treatment alone.

Conclusions:
Our study suggested that metformin and cisplatin had synergistic antitumorigenic effects in
A549/DDP cells. The combination of cisplatin and metformin could be promising drug candidates to
sensitize cisplatin-induced apoptosis through regulating nucleotide excision repair pathways in lung cancer.
Research Progress on Indoor VOC Pollution and Control
Authors: Li Xiang , Cui Rui , Yang Baojun , Xie ShiYu , Zeng Guoming , Zheng Hengwei , Zheng Huaili 
Published: April 2022

Abstract:
Nowadys, indoor air pollution is harming human health and has become a global problem.
Therefore, research on indoor air pollution is necessary. This paper systematically reviews the
research progress of indoor air pollution in recent years, mainly including indoor pollutant types
and sources, indoor pollutant detection methods and equipment, pollutant release simulation models
and quality standards, indoor air treatment technologies, and points out the problems that exist
in current researches. Furthermore, it proposes the direction of future research work.
PDL1 Positivity Rate Between Triple-negative and Non-luminal Her2+ Cases
Authors: Khalili Ehsan , Naghizadeh Mohsen , Tabriz Hedieh Moradi , Kenari Adel Yazdankhah 
Published: April 2022

Background:
Triple-negative breast cancer cases with no available targeted therapy and
advanced cases of luminal and HER2+ that become resistant to available state-of-the-art treatments
are priorities in cancer research. Immune checkpoint blockade, particularly PDL1/PD1 inhibition, is
suggested as a potential option for these patients suffering from several other types of cancers, such
as melanoma. However, the exact subpopulation of breast cancer patients that overexpress PDL1 is
yet to be completely identified. Additionally, reports on the value of PDL1 as a biomarker for the
prognosis of cancer and its correlation with clinicopathological features of malignancy are diverse.

Method:
In this study, we performed immunohistochemistry on 60 breast cancer, including 22
triple-negative and 38 HER2+ cases, and 20 paired lymph node samples.

Results:
PDL1 expression was present in 21. 6% (13/60) of breast cancer samples. PDL1 expression
is significantly associated with ER/PR negativity and the grade of the tumor. The association between
PDL1 positivity and recurrence and the overall survival of patients was not significant.

Conclusion:
PDL1 expression is similar between triple-negative and non-luminal HER2+ cases,
thus some of the advanced non-luminal HER2+ cases might be benefitted from immune checkpoint
blockade.
m5C-HPromoter: An Ensemble Deep Learning Predictor for Identifying
5-methylcytosine Sites in Human Promoters
Authors: Xiao Xuan , Shao Yu-Tao , Luo Zhen-Tao , Qiu Wang-Ren 
Published: April 2022

Aims:
This paper is intended to identify 5-methylcytosine sites in human promoters.

Background:
Aberrant DNA methylation patterns are often associated with tumor development. Moreover,
hypermethylation inhibits the expression of tumor suppressor genes, and hypomethylation stimulates
the expression of certain oncogenes. Most DNA methylation occurs on the CpGisland of the gene
promoter region.

Objective:
Therefore, a comprehensive assessment of methylation status of the promoter region of human
gene is extremely important for understanding cancer pathogenesis and the function of posttranscriptional
modification.

Method:
This paper constructed three human promoter methylation datasets, which comprise of a total
of 3 million sample sequences of small cell lung cancer, non-small cell lung cancer, and hepatocellular
carcinoma from the Cancer Cell Line Encyclopedia (CCLE) database. Frequency-based One-Hot Encoding
was used to encode the sample sequence, and an innovative stacking-based ensemble deep
learning classifier was applied to establish the m5C-HPromoter predictor.

Result:
Taking the average of 10 times of 5-fold cross-validation, m5C-HPromoter obtained a good
result in terms of Accuracy (Acc)=0.9270, Matthew's correlation coefficient(MCC)=0.7234, Sensitivity(
Sn)=0.9123, and Specificity(Sp)=0.9290.

Conclusion:
Numerical experiments showed that the proposed m5C-HPromoter has greatly improved
the prediction performance compared to the existing iPromoter-5mC predictor. The primary reason is
that frequency-based One-Hot encoding solves the too-long and sparse features problems of One-Hot
encoding and effectively reflects the sequence feature of DNA sequences. The second reason is that the
combination of upsampling and downsampling has achieved great success in solving the imbalance
problem. The third reason is the stacking-based ensemble deep learning model that overcomes the
shortcomings of various models and has the strengths of various models. The user-friendly web-server
m5C-HPromoter is freely accessible to the public at the website: http://121.36.221.79/m5C-HPromoter
or http://bioinfo.jcu.edu.cn/m5C-HPromoter, and the predictor program has been uploaded from the
website: https://github.com/liujin66/m5C-HPromoter.
Tribulus Terrestrisand its Efficacy in the Treatment of Urinary Calculi
Authors: Mahboubi Mohaddese 
Published: April 2022

Background:Urolithiasis as the third most common disorder is defined as stones within the urinary tract. Calcium oxalate is the most common type of stone with a prevalence of 80-85% of cases. There is no drug treatment for urolithiasis, but the use of some stone blockers and inhibitors relaxes the ureter smooth muscles and helps the stone excretion.Objective:High prevalence and recurrence rates of urolithiasis has encouraged scientists to find new drugs, especially from medicinal plants. Tribulus terrestris is used for the management of urinary calculi in different traditional systems. Therefore, the potential use of T. terrestris in the management of urinary stones has been the subject of this review for the first time.Methods:The manuscript was prepared by searching the keywords “Tribulus terrestris”, “urolithiasis”, “urinary stone”, and “calcium oxalate” in scientific resources, traditional and modern books, dissertations, and documents.Results:The results exhibited that T. terrestris fruit aqueous extract had some efficacy in the treatment of urinary calculi by demineralizing the stone, inhibiting the stone formation, increasing urine volume in 24 hrs in animal and human studies, along with protective effects against renal injury due to inhibition of oxidative stress and lipid peroxidation.Conclusion:All these mechanisms make T. terrestris as an effective treatment for urolithiasis that needs to be evaluated in further clinical studies.
Bio-Application of Poly (Vinyl Alcohol)/Biphasic Calcium Phosphate
Scaffold as Bone Tissue Replacement
Authors: Ismail Mukhlis M. , Hussain Wafaa A. , Hashim Furqan Salim 
Published: April 2022

Background:
Porous scaffolds composed of poly (vinyl alcohol)/Biphasic calcium
phosphate (PVA/BCP) were prepared for bone tissue engineering. The effect of BCP was investigated
on the morphology of pores, porosity, compression strength, swelling ratio, biodegradation,
bioactivity, and in vivo blood count.

Objective:
the aim of the article is to prepare a porous scaffold with good mechanical properties
and suitable for the living body by having biodegradable, bioactive, and biocompatible properties.

Methods:
The scaffold of PVA foam was prepared using 4g of PVA (Central Drug House,
M.W. 13000-23000, Viscosity 3.5-4.5, Hydrolysis 87-89 %, PH 4.5-6.5, India) dissolved in 24
ml distilled water with stirrer for 5 minutes. The biphasic-calcium phosphate (BCP) (Ying
Tong Chem and Tech, LTD, Density 3.14 g/cm3, China) was added to the solution with heat
stirring for 5 minutes with a ratio of 0, 0.05, 0.1 and 0.25 with respect to the weight of PVA as
shows in Table 1.
The sulfuric acid (Central Drug House, M.W. 98.08, India) of (8 ml) was added drop by drop using
a catalyzer. The citric acid (Central Drug House, M.W. 192.13, India) was added to the mixture
with 24g to create esterification bonding.

Results:
The results showed that the scaffold using BCP had uniform pore size distribution, suitable
porosity up to 67%, and showed high swelling ratio. The scaffolds were of biodegradable nature
and almost degraded by about 37.5% in four weeks. The scaffold was biologically active in
terms of the presence of calcium phosphate in the hydroxyapatite phase as in bone. The in vivo
biocompatibility of the PVA/BCP scaffold was tested by comparing the blood count with the
normal range of blood in rabbits. After 14 days, the Blood Urea, Creatinine, A total of Bilirubin,
and Lymphocytes were higher than the control.

Conclusion:
The addition of BCP powder has a positive effect on porosity and pore size. The
compression strength value increased significantly with the use of BCP from 2.12 to 5.29 MPa.
The scaffolds show good biodegradation and well bioactivity. The culture of the biomaterial
caused toxicity or an acute inflammatory response, as the blood test results showed that there was
infiltration of polymorphous leukocytes, lymphocytes, macrophages, and fibroblasts.
TREN ANGKA PARTISIPASI PENDIDIKAN SD DAN SMP DI KABUPATEN GUNUNGKIDUL
Authors: Rachmawati Ani 
Published: April 2022

This research aims to: 1. Describe the trend in the enrollment rate of SD and SMP in Gunungkidul; 2. Describe the policies and programs that have been provided by the Gunungkidul Government to increase enrollment rates for elementary and junior high schools; 3. Describe the follow-up action of the Gunungkidul Government after seeing the trend of elementary and junior high school enrollment rates in Gunungkidul Regency. This research uses descriptive quantitative research with secondary data analysis which is equipped with interview method. Analysis of the data using trend analysis of the number of least squares with the type of linear model and the equation Y = a + bx. The results of this study are: 1. The trend of GER for SD and SMP in 2019-2028 in Gunungkidul tends to decrease; 2. Policies and programs of the Gunungkidul Government through PIP, scholarships and social assistance, compulsory education movement programs, retrieval programs, google for education, and education and training for educators; 3. The Gunungkidul government is following up on the results of the SD and SMP GER trends by validating data, continuing effective programs, and maximizing retrieval programs. Keywords: trends, gross participation rate, primary school, junior high school, gunungkidul regency.
ADVOKASI ADMINISTRASI KEPENDUDUKAN UNTUK MENGAKSES PENDIDIKAN OLEH PERKUMPULAN HARAPAN FIAN YOGYAKARTA
Authors: Amalia Ulfa Dwi 
Published: April 2022

Penelitian ini bertujuan mendeskripsikan advokasi administrasi kependudukan serta faktor yang mendukung dan menghambat advokasi yang dilakukan oleh Perkumpulan Harapan Fian Yogyakarta. Penelitian ini menggunakan pendekatan kualitatif dengan jenis deskriptif. Hasil penelitian yang diperoleh: (1) langkah yang dilakukan oleh Harapan Fian yaitu, (a) Tahap Persiapan, menjaring orang-orang yang memiliki permasalahan dokumen administrasi kependudukan dan pencarian data untuk merancang strategi, (b) Tahap Pelaksanaan, melaksanakan strategi yang telah dirancang pada tahap persiapan, dan (c) Tahap Penilaian, menilai bahwa terdapat kesulitan dan hambatan dari instansi yang dituju. (2) Faktor pendukung: Harapan Fian menggunakan pendekatan yang sesuai dengan subjek dampingannya; data yang lengkap dan mendalam memudahkan proses; dan menjalin koalisi dengan komunitas yang selaras, serta Harapan Fian telah memiliki badan hukum sebagai sebuah perkumpulan. Faktor penghambatnya yaitu instansi sasaran terkadang cukup strict, perizinan RT dan RW yang terkadang sulit didapatkan, stigma negatif tentang orang di situasi jalanan, serta isu administrasi kependudukan yang masih minor. Kata kunci: Advokasi, Administrasi Kependudukan, dan Perkumpulan Harapan Fian
STRATEGI SEKOLAH DALAM MENGEMBANGKAN KULTUR SEKOLAH ANTI BULLYING DI SMA NEGERI 2 WATES KULONPROGO
Authors: Maesaroh Erna 
Published: April 2022

Abstrak Tujuan dari penelitian ini adalah mendeskripsikan mengenai strategi sekolah dalam mengembangkan kultur sekolah anti bullying di SMA Negeri 2 Wates. Pendekatan penelitian yang digunakan adalah kualitatif dengan metode deskriptif. Subjek penelitian adalah kepala sekolah, wakil kepala sekolah bagian kesiswaan, guru BK, guru mata pelajaran, dan siswa. Pengumpulan data dilakukan dengan observasi, wawancara, dan dokumentasi. Analisis data dilakukan dengan menggunakan model interaktif Miles dan Huberman yaitu reduksi data, penyajian data, dan verifikasi. Hasil penelitian menunjukkan adanya strategi yang dilakukan sekolah dengan cara mengembangkan nilai-nilai anti bullying, dibuatnya program anti bullying, membiasakan warga sekolah untuk bersalaman menyapa dan berperilaku sopan, semua aktor warga sekolah dilibatkan dalam anti bullying, adanya artefak yang menunjang berupa pos satpam, ruang PIK-R, ruang bimbingan konseling, dan slogan anti bullying. Kata kunci: Strategi, Kultur Sekolah, Anti Bullying Abstract This study aims to describe the school’s strategy in developing anti-bullying school culture in 2 Wates High School. This research used a qualitative approach descriptive method. The subjects of this research were the headmaster, deputy headmaster, for student affairs, conseling guidance teacher, subject teachers, and student. Data collection is done through observation, interview, and documentation. The research instrument uses observation guidelines, interview guidelines, and documentation guidelines. Data analysis techniques use an interactive model of Miles and Huberman that is data reduction, data presentation, and conclusion. The results showed that the school has a strategy in developing anti-bullying school culture. These strategies include: the development of anti-bullying values, there are programs or activities created, accoustom the school community every day to shake hands, greet and behave politely. Supporting artifacts, namely security post, PIK-R room, counselimg guidance room, and anti-bullying slogan. Keywords: Strategy, School Culture, Anti-Bullying
Development of Multi-Material-Joint Made of Copper-Coated FRP and Steel by Innovative Technology Fusion
Authors: Gebauer Jana , Drehmann Rico , Eisner Kevin , Kupke David , Lasagni Andrés Fabian 
Published: April 2022

Several technologies have been developed to join metal and polymer, such as adhesive bonding, clinching or screwing. These have disadvantages in terms of creep tendency of the adhesives or structural damage to the fiber-reinforced plastic (FRP).
An innovative process chain consisting of laser pre-treatment of the FRP before metallization by thermal spraying and the subsequent low-temperature soldering process enable a reliable multi-material bond, without structural damage either of the FRP or the metal part. In addition to a rough joining surface, the laser pre-treatment enables the deep interlocking of the thermally sprayed copper coating with the carbon fibre-reinforced plastic (CFRP) substrate. After the adhesion strength of the copper-coated CFRP could be doubled to 18 MPa compared to grit-blasting, this hybrid was joined to a steel counterpart with a soft solder BiSnAg1 using infrared heating. Additionally, the hybrid achieved a flexural stress of 1128.0 MPa in a 4-point-bending test without coating impairment. The multi-material joint achieved up to 15.5 MPa in the tensile shear test. During fatigue testing, the specimens withstood 5.000.000 load cycles at a maximum stress of 15 MPa and a mean stress of 8.6 MPa without any measurable structural damage. After salt water aging, the joining zone remained unaffected.
Aspek – Aspek Penting Membangun Kehidupan di Desa Menuju Kesejahteraan dan Keadilan Sosial
Authors: Abustan Abustan 
Published: April 2022

Development in the village is an integral part of national development based on Pancasila and the Constitution of the Republic of Indonesia of 1945, implemented to realize equitable development throughout Indonesia which is not only concentrated in the city, but also in remote villages where the majority of the population actually lives in the interior. The dynamics of development infrastructure have recently moved to the village as a manifestation of the realization of a prosperous, socially just, and equitable society. Of course, it is not limited to material development but also spiritual. This research takes the subject of discussion about the aspects that concern the government in the implementation of village development in realizing welfare and social justice. The purpose of the research is to find out the aspects that concern the government in the implementation of village development in realizing welfare and social justice. This research is empirical research that uses a sociological juridical approach. The reality of the conditions in the village, in the research, conducted found various advances that exist, both in the sector of education of the reflective school infrastructure, health facilities were people for treatment (Posyandu and Puskesmas), and people's activities equipped with information technology with digitalization systems (Wifi). That is the development of development progress found from the research conducted.
Abstrak
Pembangunan di desa merupakan bagian integral dari pembangunan nasional berdasarkan Pancasila dan Undang-undang Dasar Negara Republik Indonesia Tahun 1945, dilaksanakan untuk mewujudkan pemerataan pembangunan seluruh Indonesian yang tidak hanya terpusat (terkonsentrasi) di kota, tetapi juga di pelosok desa yang mayoritas penduduk kenyataannya bermukim di pedalaman. Dinamika infrastruktur pembangunan akhir-akhir ini bergerak ke desa sebagai manifestasi dari perwujudan masyarakat sejahtera, berkeadilan sosial, dan merata. Tentu saja, tidak sebatas pembangunan materiil namun juga spiritual. Penelitian ini mengambil pokok bahasan tentang aspek-aspek yang menjadi perhatian pemerintah dalam implementasi pembangunan desa dalam mewujudkan kesejahteraan dan keadilan sosial. Tujuan penelitian untuk mengetahui aspek-aspek yang menjadi perhatian pemerintah dalam implementasi pembangunan desa dalam mewujudkan kesejahteraan dan keadilan sosial. Penelitian ini merupakan penelitian empiris yang menggunakan pendekatan yuridis sosiologis. Realitas kondisi yang ada di desa, dalam penelitian yang dilakukan ditemukan berbagai kemajuan yang ada, baik di sektor pendidikan infrastruktur sekolah yang refresentatif, sarana kesehatan tempat masyaraka untuk berobat (Posyandu dan Puskesmas) serta aktifitas rakyat yang dilengkapi tehnologi informasi dengan sistem digitalisasi (Wifi). Itulah perkembangan kemajuan pembangunan yang ditemukan dari riset yang dilakukan.