bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing gene expression in an in vitro biomechanical strain model of joint health
Authors: Hung Anthony , Housman Genevieve , Briscoe Emilie A. , Cuevas Claudia , Gilad Yoav 
Published: September 2022

Background: Both genetic and environmental factors appear to contribute to joint health and disease. For example, pathological levels of biomechanical stress on joints play a notable role in initiation and progression of osteoarthritis (OA), a common chronic degenerative joint disease affecting articular cartilage and underlying bone. Population-level gene expression studies of cartilage cells experiencing biomechanical stress may uncover gene-by-environment interactions relevant to human joint health. Methods: To build a foundation for population-level gene expression studies in cartilage, we applied differentiation protocols to develop an in vitro system of chondrogenic cell lines (iPSC-chondrocytes). We characterized gene regulatory responses of three human iPSC-chondrocyte lines to cyclic tensile strain treatment. We measured the contribution of biological and technical factors to gene expression variation in this system. Results: We identified patterns of gene regulation that differ between strain-treated and control iPSC-chondrocytes. Differentially expressed genes between strain and control conditions are enriched for gene sets relevant to joint health and OA. Furthermore, even in this small sample, we found several genes that exhibit inter-individual expression differences in response to mechanical strain, including genes previously implicated in OA. Conclusions: Expanding this system to include iPSC-chondrocytes from a larger number of individuals will allow us to characterize and better understand gene-by-environment interactions related to joint health.
Modelling time-varying volatility using GARCH models: evidence from the Indian stock market
Authors: Ali Farman , Suri Pradeep , Kaur Tarunpreet , Bisht Deepa 
Published: September 2022

Background: In this study, we examined the volatility of the Indian stock market from 2008 to 2021. Owing to the financial crisis, volatility forecasting of the Indian stock market has become crucial for economic and financial analysts. An empirical study of the returns of the NSE indices revealed an autoregressive conditional heteroskedastic trend in the Indian stock market. Methods: Using GARCH 1, 1 (generalized autoregressive conditional heteroskedasticity) and FIGARCH (fractionally integrated GARCH), we examine investor behaviour and the persistence of long-term volatility. Results: The empirical findings of the estimated models suggest that shocks persist for a long time in NSE returns. Furthermore, bad news has a greater impact on stock volatility than good news. The return on assets is stable but highly volatile, even though the Indian economy has experienced the global crash to some extent. Conclusions: Models of volatility derived from the GARCH equation provide accurate forecasts and are useful for portfolio allocation, performance measurement, and option valuation.
Study of the Quality of the Conditions for the Implementation of Educational Activities by Educational Organizations of General, Secondary Vocational and Additional Education in 2020 and 2021
Authors: Ganeev A. , Bulaeva N. , Ruban I. 
Published: September 2022

The article presents the results of the research on an independent assessment of the quality of the conditions for the implementation of educational activities by organizations engaged in educational activities in basic general education programs, educational programs of secondary vocational education, basic vocational training programs, additional general education programs, which was carried out in 2020-2021. The collection and synthesis of data as part of an independent assessment was carried out by order of the Ministry of Education of the Russian Federation on the basis of indicators approved by Order of the Ministry of Education of Russia dated March 13, 2019 No. 114, and in accordance with the Unified Procedure for Calculating Indicators approved by Order of the Ministry of Labor and Social Protection of the Russian Federation dated May 31, 2018 No. 344n.
The article compares the integral values of the quality criteria of the conditions for the implementation of educational activities for 2020 and 2021, changes in the values of the criteria for assessing the quality of the conditions for the implementation of educational activities are noted.
Symptom burden according to dialysis day of the week in three times a week haemodialysis patients
Authors: Hnynn Si Pann Ei , Gair Rachel , Barnes Tania , Dunn Louese , Lee Sonia , Ariss Steven , Walters Stephen J. , Wilkie Martin , Fotheringham James 
Published: September 2022

Background
Haemodialysis patients experience significant symptom burden and effects on health-related quality of life. Studies have shown increases in fluid overload, hospitalization and mortality immediately after the long interdialytic interval in thrice weekly in-centre haemodialysis patients, however the relationship between the dialytic interval and patient reported outcome measures (PROMs) has not been quantified and the extent to which dialysis day of PROM completion needs to be standardised is unknown.

Methods
Three times a week haemodialysis patients participating in a stepped wedge trial to increase patient participation in haemodialysis tasks completed PROMs (POS-S Renal symptom score and EQ-5D-5L) at recruitment, six, 12 and 18 months. Time from the long interdialytic interval, HD day of the week, and HD days vs non-HD days were included in mixed effects Linear Regression, estimating severity (none to overwhelming treated as 0 to 4) of 17 symptoms and EQ-5D-5L, adjusting for age, sex, time on HD, control versus intervention and Charlson Comorbidity Score.

Results
517 patients completed 1659 YHS questionnaires that could be assigned HD day (510 on Mon/Tue/Sun, 549 on Wed/Thu/Tue, 308 on Fri/Sat/Thu and 269 on non-HD days). With the exception of restless legs and skin changes, there was no statistically significant change in symptom severity or EQ-5D-5L with increasing time from the long interdialytic interval. Patients who responded on non-HD days had higher severity of poor appetite, constipation, difficulty sleeping, poor mobility and depression (approximately 0.2 severity level), and lower EQ-5D-5L (-0.06, CI -0.09 to -0.03) compared to HD days.

Conclusions
Measuring symptom severity and EQ-5D-5L in haemodialysis populations does not need to account for dialysis schedule, but completion either on HD or non-HD days could introduce bias that may impact evaluation of interventions. Researchers should ensure completion of these instruments are standardized on either dialysis or non-dialysis days.
Perspectives from designated family caregivers of critically ill adult patients during the COVID-19 pandemic: A qualitative interview study
Authors: Moss Stephana J. , Krewulak Karla D. , Stelfox Henry T. , Patten Scott B. , Doig Christopher J. , Parsons Leigh Jeanna , Fiest Kirsten M. 
Published: September 2022

BackgroundFamily visitation in intensive care units (ICU) has been impacted by the severe acute respiratory syndrome coronavirus 2 (COVID-19) pandemic. While studies report on perceptions of families completely restricted from ICUs, little is known about the burden experienced by designated family caregivers allowed to visit their critically ill loved one. This study sought the perspectives of family caregivers of critically ill patients on the impact of one-person designated visitor policies mandated in ICUs during the COVID-19 pandemic.MethodsThroughout the study period a restricted visitation policy was mandated capturing the first (April 2020) and second (December 2020) waves of the pandemic that allowed one designated family caregiver (i.e., spouses or adult children) per patient to visit the ICU. Designated family caregivers of critically ill patients admitted to ICU September 2020 to November 2020 took part in individual 60-minute, semi-structured interviews at 6-months after discharge from the index ICU admission. Themes from family interviews were summarized with representative quotations.ResultsKey themes identified following thematic analysis from six participants included: one visitor rule, patient advocate role, information needs, emotional distress, strategies for coping with challenges, practicing empathy, and appreciation of growth.ConclusionDesignated family caregivers of critically ill patients admitted to ICU during the COVID-19 pandemic perceived a complex and highly stressful experience. Support from ICU family liaisons and psychologists may help ameliorate the impact.
Endoscopic Ultrasound-Guided Fine Needle Aspiration (FNA) Combined with Fine Needle Biopsy (FNB) in the Diagnosis and Subclassification of Deep-Seated Lymphomas - Report of a Case Series and Review of Literature
Authors: Deepak Johnson  , Ajitha Kumari  , Asha Punnoose  , Sany Philip  , George Chandy Mattethra  
Published: September 2022

BACKGROUND
Evaluation of intra-abdominal/intrathoracic lymphadenopathy in the absence of enlarged peripheral nodes has always been a challenging problem for clinicians, especially with unfavourable general conditions of the patient where surgical interventions are difficult. Endoscopic ultrasound-guided FNA has been used for the last two decades for tissue acquisition from patients with such deep-seated lesions. But its use in the diagnosis of lymphoma has always been challenging. However, the addition of fine needle core biopsy into this procedure has given promising results. In this study, we wanted to evaluate the effectiveness of EUS-FNA/FNB as an alternative to invasive open surgical procedures.
METHODS
We exhibit a case series of 6 patients who presented with mediastinal and/ or intraabdominal lymphadenopathy in whom EUS-FNA & FNB were done simultaneously to obtain tissue for histological and ancillary studies.
RESULTS
Clinically these lymph nodes were detected by CECT and there was no peripheral lymphadenopathy. In this case series, we were able to make a diagnosis of lymphoma in all 6 cases. With the help of immunohistochemistry, 2 cases were further classified into Hodgkin’s lymphoma and one case was diagnosed as ALK-positive anaplastic large cell lymphoma. All three patients underwent treatment from our hospital and are on follow-up.
CONCLUSIONS
Our experience with this case series report suggests that EUS-FNA/FNB is a minimally invasive procedure which can be tried effectively as an alternative to invasive open surgical procedures.
Epicurean Feelings (pathē) as Criteria
Authors: Robitzsch Jan Maximilian 
Published: September 2022

Abstract
This paper is dedicated to feelings (pathē) as criteria of truth and criteria of choice and avoidance in Epicureanism. The first section reviews two features of the other two Epicurean criteria of truth, perceptions and preconceptions: their non-rational and evident character. The second section extends the account to feelings, showing how, on the basis of their non-rational and evident character, feelings can be used to gain insights. The third section of the paper finally turns to feelings as criteria of choice and avoidance. It examines some neglected textual evidence that shows that perceptions and feelings are closely connected to each other, that is, that Epicurean feelings are defined as perceptions and observances of themselves, shedding some new light on the joint role of feelings and perceptions in choices and avoidances.
An Urban Configuration with Online Competition
Authors: Lai Fu-Chuan 
Published: September 2022

Abstract
This paper introduces the impact of online competition to analysis of the urban configuration of a small open city, which was first developed by Alonso (1964. Location and Land Use. Cambridge: Harvard University Press), Mills (1967. “An Aggregative Model of Resource Allocation in a Metropolitan Area.” The American Economic Review 57 (2): 197–210), and Muth (1969. Cities and Housing. Chicago: University of Chicago Press) (AMM hereafter). In comparison to a revised AMM model in Lai and Tsai (2008. “Simplified Alonso-Mills-Muth Model with a Monopoly Vendor.” Journal of Urban Economics 63 (2): 536–43) which assumed a monopoly vendor, the present paper’s online entry brings competition, eventually causes price reduction, city expansion, and asymmetrically ascending land rent, and makes the incumbent vendor relocate to a more remote city boundary. When the disadvantage of online purchasing is not large, the urban configuration demonstrates that most residents purchase online, and only the residents living near the physical vendor make shopping trips. Finally, the benefit of city expansion from online competition eventually goes to the absentee landowners by way of the raised land rents.
Computer aided detection of tuberculosis using two classifiers
Authors: Umar Ibrahim Abdullahi , Al-Turjman Fadi , Ozsoz Mehmet , Serte Sertan 
Published: September 2022

Abstracts
Tuberculosis caused by Mycobacterium tuberculosis have been a major challenge for medical and healthcare sectors in many underdeveloped countries with limited diagnosis tools. Tuberculosis can be detected from microscopic slides and chest X-ray but as a result of the high cases of tuberculosis, this method can be tedious for both microbiologist and Radiologist and can lead to miss-diagnosis. The main objective of this study is to addressed these challenges by employing Computer Aided Detection (CAD) using Artificial Intelligence-driven models which learn features based on convolution and result in an output with high accuracy. In this paper, we described automated discrimination of X-ray and microscopic slide images of tuberculosis into positive and negative cases using pretrained AlexNet Models. The study employed Chest X-ray dataset made available on Kaggle repository and microscopic slide images from both Near East university hospital and Kaggle repository. For classification of tuberculosis and healthy microscopic slide using AlexNet+Softmax, the model achieved accuracy of 98.14%. For classification of tuberculosis and healthy microscopic slide using AlexNet+SVM, the model achieved 98.73% accuracy. For classification of tuberculosis and healthy chest X-ray images using AlexNet+Softmax, the model achieved accuracy of 98.19%. For classification of tuberculosis and healthy chest X-ray images using AlexNet+SVM, the model achieved 98.38% accuracy. The result obtained has shown to outperformed several studies in the current literature. Future studies will attempt to integrate Internet of Medical Things (IoMT) for the design of IoMT/AI-enabled platform for detection of Tuberculosis from both X-ray and Microscopic slide images.
Calibration of insulin pumps based on discrete doses at given cycle times
Authors: Bissig Hugo , Büker Oliver , Stolt Krister , Batista Elsa , Afonso Joana , Zagnoni Michele , Vroman Rozan , Kjeldsen Henrik , Niemann Anders , Schroeter Joerg 
Published: September 2022

Abstract
One application in the medical treatment at very small flow rates is the usage of an Insulin pump that delivers doses of insulin at constant cycle times for a specific basal rate as quasi-continuous insulin delivery, which is an important cornerstone in diabetes management. The calibration of these basal rates are performed by either gravimetric or optical methods, which have been developed within the European Metrology Program for Innovation and Research (EMPIR) Joint Research Project (JRP) 18HLT08 Metrology for drug delivery II (MeDDII). These measurement techniques are described in this paper, and an improved approach of the analytical procedure given in the standard IEC 60601-2-24:2012 for determining the discrete doses and the corresponding basal rates is discussed in detail. These improvements allow detailed follow up of dose cycle time and delivered doses as a function of time to identify some artefacts of the measurement method or malfunctioning of the insulin pump. Moreover, the calibration results of different basal rates and bolus deliveries for the gravimetric and the optical methods are also presented. Some analysis issues that should be addressed to prevent misinterpreting of the calibration results are discussed. One of the main issues is the average over a period of time which is an integer multiple of the cycle time to determine the basal rate with the analytical methods described in this paper.
Rapid exponential stabilization of nonlinear continuous systems via event-triggered impulsive control
Authors: Dlala Mohsen 
Published: September 2022

Abstract
This article investigates the problem of rapid exponential stabilization for nonlinear continuous systems via event-triggered impulsive control (ETIC). First, we propose a trigger mechanism that, when triggered by a predefined event, causes the closed-loop system exponentially stable. Then, the exponential stabilization is achieved by the designed ETIC with or without data dropout. The case where there are delays in the ETIC signals is also studied, and the exponential stabilization is proved. Finally, a numerical study is presented, along with numerical illustrations of the stability results.
Mathematical expressions describing enzyme velocity and inhibition at high enzyme concentration
Authors: Hernández Agustín 
Published: September 2022

Abstract
Enzyme behaviour is characterised in the laboratory using diluted solutions of enzyme. However, in vivo processes usually occur at [S

T
] ≈ [E

T
] ≈ K

m
. Furthermore, the study of enzyme action involves characterisation of inhibitors and their mechanisms. However, to date, there have been no reports proposing mathematical expressions that can be used to describe enzyme activity at high enzyme concentration apart from the simplest single substrate, irreversible case. Using a continued fraction approach, equations can be easily derived for the most common cases in monosubstrate reactions, such as irreversible or reversible reactions and effector (inhibitor or activator) kinetic interactions. These expressions are an extension of the classical Michaelis-Menten equations. A first analysis using these expressions permits to deduce some differences at high versus low enzyme concentration, such as the greater effectiveness of allosteric inhibitors compared to catalytic ones. Also, they can be used to understand catalyst saturation in a reaction. Although they can be linearised, these equations also show differences that need to be taken into account. For example, the different meaning of line intersection points in Dixon plots. All in all, these expressions may be useful tools for modelling in vivo and biotechnological processes.
On closed subgroups of precompact groups
Authors: Hernández Salvador , Remus Dieter , Trigos-Arrieta F. Javier 
Published: September 2022

Abstract
It is a theorem of W. W. Comfort and K. A. Ross that if 𝐺 is a subgroup of a compact Abelian group and 𝑆 denotes the continuous homomorphisms from 𝐺 to the one-dimensional torus, then the topology on 𝐺 is the initial topology given by 𝑆.
Assume that 𝐻 is a subgroup of 𝐺.
We study how the choice of 𝑆 affects the topological placement and properties of 𝐻 in 𝐺.
Among other results, we have made significant progress toward the solution of the following specific questions.
How many totally bounded group topologies does 𝐺 admit such that 𝐻 is a closed (dense) subgroup?
If

C
S

C_{S}

denotes the poset of all subgroups of 𝐺 that are 𝑆-closed, ordered by inclusion, does

C
S

C_{S}

have a greatest (resp. smallest) element?
We say that a totally bounded (topological, resp.) group is an SC group (topologically simple, resp.) if all its subgroups are closed (if 𝐺 and

{
e
}

\{e\}

are its only possible closed normal subgroups, resp.)
In addition, we investigate the following questions.
How many SC-(topologically simple totally bounded, resp.) group topologies does an arbitrary Abelian group 𝐺 admit?
On the practical point of view of option pricing
Authors: Halidias Nikolaos 
Published: September 2022

Abstract
In this note, we describe a new approach to the option pricing problem by introducing the notion of the safe (and acceptable) price for the writer of an option, in contrast to the fair price used in the Black–Scholes model.
Our starting point is that the option pricing problem is closely related with the hedging problem by practical techniques.
Recalling that the Black–Scholes model does not give us the price of the option but the initial value of a replicating portfolio, we observe easily that this has a serious disadvantage because it assumes the building of this replicating portfolio continuously in time, and this is a disadvantage of any model that assumes such a construction.
Here we study the problem from the practical point of view concerning mainly the over-the-counter market.
This approach is not affected by the number of the underlying assets and is particularly useful for incomplete markets.
In the usual Black–Scholes or binomial approach or some other approaches, one assumes that one can invest or borrow at the same risk-free rate

r
>
0

r>0

, which is not true in general.
Even if this is the case, one can immediately observe that this risk-free rate is not a universal constant but is different among different people or institutions.
So the fair price of an option is not so much fair!
Moreover, the two sides are not, in general, equivalent against the risk; therefore, the notion of a fair price has no meaning at all.
We also define a variant of the usual binomial model, by estimating safe upward and downward rates

u
,
d

u,d

, trying to give a cheaper safe or acceptable price for the option.