bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin D Deficiency Reduces Postthyroidectomy Protracted Hypoparathyroidism Risk. Is Gland Preconditioning Possible?
Authors: Martín-Román Lorena , Colombari Renan , Fernández-Martínez María , Amunategui-Prats Iñaki , Escat-Cortés José Luis , Zaraín-Obrador Leire , Mercader-Cidoncha Enrique 
Published: December 2022

AbstractContextHypoparathyroidism is the most frequent complication after total thyroidectomy (PT-hypoPTH). After 1 year, most patients recover parathyroid function; however, the implicated physiologic dynamics remain unknown. Vitamin D deficiency (VDD) is the main cause of secondary hyperparathyroidism. Whether this compensatory hyperparathyroidism could influence parathyroid function recovery (PFR) in the setting of PT-hypoPTH has not been studied.ObjectiveThis work aimed to evaluate the effect of preoperative VDD on PFR.MethodsA retrospective study was conducted with a prospectively maintained database including patients undergoing a total thyroidectomy between May 2014 and June 2019. Preoperative vitamin D (25(OH)D) less than 20 mg/mL was defined as VDD. Intact PTH less than 14 pg/mL on postoperative day 1 was defined as PT-hypoPTH. Transient PT-hypoPTH displayed PFR within the first year (early recovery: &lt; 30 days; protracted recovery: &gt; 30 days) whereas definite PT-hypoPTH did not. Survival analysis evaluated the effect of preoperative VDD on PFR, and a binary logistic regression model identified associated factors.ResultsA total of 397 patients were identified. The observed rates of transient, protracted, and definite PT-hypoPTH were 32.9%, 15.1%, and 5.2%, respectively. Rates of VDD were higher in the early-recovery PT-hypoPTH group (55.2% vs 31.5%; P = .01). Preoperative VDD was associated with faster PFR (19 vs 35 days; P = .03) and behaved as a protective factor for protracted PT-hypoPTH (odds ratio 0.47; 95% CI, 0.25-0.881; P = .016) in the multivariable analysis.ConclusionPreoperative VDD could act as a preconditioning factor of the parathyroid glands prior to the surgical aggression exerted against them during surgery aiding PFR. Basic research studies and prospective clinical trials are needed to explain the underlying physiological mechanisms and to provide further evidence to improve clinical management.
A DUSP6 inhibitor suppresses inflammatory cardiac remodeling and improves heart function after myocardial infarction
Authors: Zhang Zongwang , Chen Yang , Zheng Lixia , Du Jianyong , Wei Shicheng , Zhu Xiaojun , Xiong Jing-Wei 
Published: December 2022

ABSTRACT
Acute myocardial infarction (MI) results in loss of cardiomyocytes and abnormal cardiac remodeling with severe inflammation and fibrosis. However, how cardiac repair can be achieved by timely resolution of inflammation and cardiac fibrosis remains incompletely understood. Our previous findings have shown that dual-specificity phosphatase 6 (DUSP6) is a regeneration repressor from zebrafish to rats. In this study, we found that intravenous administration of the DUSP6 inhibitor (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one (BCI) improved heart function and reduced cardiac fibrosis in MI rats. Mechanistic analysis revealed that BCI attenuated macrophage inflammation through NF-κB and p38 signaling, independent of DUSP6 inhibition, leading to the downregulation of various cytokines and chemokines. In addition, BCI suppressed differentiation-related signaling pathways and decreased bone-marrow cell differentiation into macrophages through inhibiting DUSP6. Furthermore, intramyocardial injection of poly (D, L-lactic-co-glycolic acid)-loaded BCI after MI had a notable effect on cardiac repair. In summary, BCI improves heart function and reduces abnormal cardiac remodeling by inhibiting macrophage formation and inflammation post-MI, thus providing a promising pro-drug candidate for the treatment of MI and related heart diseases.
This article has an associated First Person interview with the first author of the paper.
Sustainability of quality of life investments based on the digital transformation
Authors: Evgenievich Barykin Sergey , Mikhailovich Sergeev Sergey , Vasilievna Kapustina Irina , de la Poza Elena , Nikolaevna Borisoglebskaya Larisa , Varlamova Daria , Serezhaevna Ovakimyan Marianna , Evgenievna Karmanova Anna 
Published: December 2022

Background: In this paper, the problem of sustainability of investment activity in the direction of the high yield investment program is considered. In these financial instruments, large amounts of money are accumulated, consisting of contributions from the vast majority of the population. For example, pension funds inherent in most developed countries, insurance institutions, etc., can be indicated. Accordingly, the social significance of their activities and the impact on the quality of life of all segments of the population increase. Methods: This article outlines the methods and results aimed at the digital transformation of methods for forecasting long-term institutional investments. The authors use the method of mathematical modeling of the dynamics considering that the sustainability calculation must assume that the life cycle of citizens providing contributions is limited. The parameters of the distribution of the duration of the accumulation phase over the array of people and the time of life in the subsequent period are known. For mathematical modeling, the researchers divide the players by the time they have been present on the market. Results: The authors have developed a mathematical model in the form of a set of algorithms for calculating the sustainability of long-term institutional investments with reference to life quality indicators. Conclusions: The need to develop a methodology for assessing sustainability is dictated by the increased role of digital technologies and the ability to receive the most relevant information for analysis online.
Risk factors and mortality outcomes of extended-spectrum beta-lactamase producing Escherichia coli bacteremia: A retrospective cohort study from two Indonesian referral hospitals
Authors: Siregar Masra Lena , Nelwan Erni Juwita , . Eppy , Haryanto Budi , Puspandari Nelly , Sinto Robert , Nainggolan Leonard , Bonar Maruhum , Shatri Hamzah 
Published: December 2022

Background: Bacteremia caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) can lead to bloodstream infection and subsequent sepsis which increases morbidity and mortality. Evaluation of risk factors of infection by ESBL-producing E. coli is important as it can decrease inappropriate antibiotic use and mortality rates. This study aimed to identify the risk factors and mortality of bacteremia caused by ESBL-producing E. coli. Methods: This retrospective cohort study included inpatients with confirmed E. coli blood culture examinations from two referral hospitals in Jakarta, Indonesia. Data suspected as risk factors for ESBL-producing E. coli bacteremia (utilization of medical devices, age, Charlson Comorbidity Index, history of hospitalization, and history of antibiotic therapy) were collected for analysis. Clinical profiles and independent risk factors of ESBL-producing E. coli bacteremia associated mortality were also evaluated. Results: A total of 116 subjects were analyzed with 81% aged ≥18 years old. The most common source of infection was the gastrointestinal and intra-abdominal tracts. Malignancy as comorbidity was present in 46.6% subjects. Significant risk factors for developing ESBL-producing E. coli bacteremia were history of antibiotic therapy and utilization of medical devices. The proportion of mortality in ESBL-producing E. coli bacteremia was 55.7% with age and sepsis as its independent risk factors. Conclusions: History of antibiotic therapy and utilization of medical devices were significant risk factors for ESBL-producing E. coli bacteremia. The proportion of mortality in ESBL-producing E. coli bacteremia patients was 55.7% with its independent risk factors being age and sepsis.
O FENÔMENO MIGRATÓRIO NO CENÁRIO DO ESTADO TRANSBORDADO: OS CASOS DAS OPINIÕES CONSULTIVAS (OC – 18/03 E OC – 21/14) DA CIDH E DA SAÚDE GLOBAL
Authors: Hoffmam Fernando , Frescura Ceolin Raquel , Siqueira Lemes Fernanda 
Published: December 2022

O objetivo geral do presente artigo é discorrer sobre o fenômeno migratório no cenário da pluralidade normativa, bem como sobre a internacionalização do direito na contemporaneidade, partindo para a análise das opiniões consultivas da Corte Interamericana de Direitos Humanos quanto aos fluxos migratórios, e após, à questão da saúde global. Diante deste cenário este trabalho tem como questionamento: Qual a importância do fenômeno da pluralidade normativa e da internacionalização do direito, com base nas decisões da Corte Interamericana de Direitos Humanos, no âmbito da migração e da saúde global? A metodologia baseou-se em uma pesquisa bibliográfica que focalizou em conceitos sobre a temática, bem como de abordagem hipotético-dedutiva, pois parte-se da análise da internacionalizão do direito na contemporaneidade, e em um ambiente de pluralidade normativa, para o caso da Corte Interamericana de Direitos Humanos, os fluxos migratórios e à saúde global, verificando-se no diálogo e pluralidade normativa, na multiplicidade de organizações e na internaciozalição do direito, uma possibilidade de garantia e concretização dos direitos humanos nos casos abordados – pelo direito humano de migrar. 10.12957/rfd.2020.32670
CRÍTICAS AO PACTO FEDERATIVO BRASILEIRO: ASSIMETRIA DE DIREITO, MUNICIPALISMO E ANTAGONISMO DO FEDERALISMO FISCAL
Authors: Liziero Leonam , Zilli Tiago 
Published: December 2022

Partindo da análise hipotético-dedutiva do problema acerca da centralismo no Estado federal brasileiro, a presente pesquisa busca expor três estudos críticos redigidos por especialistas, que versam de temas tais como: distinções entre federalismo e Estado Federal; o princípio da senda federalista no Brasil; o cunho centralizado e nominal do federalismo brasileiro; a particularidade do Município como ente federal; as problemáticas do federalismo fiscal; o federalismo em crise; e, por fim a relação entre sociedade e federalismo. Com intuito de expor dentro das formulações metodológicas condizentes, serão apontados estes aspectos que reforçam o caráter renegado do Pacto por parte dos mandatários do Poder Central. Por fim, demonstra-se que problemas antigos das relações federativas no Brasil permanecem após a promulgação da Constituição de 1988. 10.12957/rfd.2020.40550
A INSERÇÃO TAXATIVA DE NORMAS CONSTITUCIONAIS NO CPC/2015 - A ANTINOMIA ENTRE A RAZOÁVEL DURAÇÃO DO PROCESSO E O ARTIGO. 10º DA LEI 13.105/2015
Authors: Lopes Júnior Newton De Araújo 
Published: December 2022

Objetivou-se com este trabalho tratar sobre as situações controversas que as inovações legislativas do Novo Código de Processo Civil criaram sob o pretexto de tutelar princípios constitucionais. O problema da pesquisa, cinge na antinomia existente entre a necessidade obrigatória da oitiva das partes, até mesmo em questões que poderiam ser decididas de ofício e a razoável duração do processo. O objetivo geral é demonstrar que o excesso de zelo com o princípio do contraditório, não coaduna com a razoável duração do processo. Optou-se pela análise bibliográfica e jurisprudencial com suporte no método dedutivo. Como resultado observou-se que em muitas situações a demasiada preocupação com a denominada não-surpresa das decisões, gera evidente conflito com o princípio constitucional da razoável duração do processo. 10.12957/rfd.2021.42568
An observational study of wounds treated with hydro-responsive wound dressings
Authors: Goedecke Falk , Bühring Jan , Kratz Antonia , Schweiger Wolfgang , Köhle Claudia , Waidner Uta , Riedel Thomas , Walter Andreas , Skrowny Patricia , Rothenaicher Gerhard , Segiet Agnieszka , Rabczenko Daniel , Rogers Alan , Rippon Mark 
Published: December 2022

Objective: Acute and hard-to-heal wounds are a significant burden to both a patient's quality of life and resources in healthcare systems. Here, we evaluate the outcomes of a non-comparative case series study in which Ringer's solution-preactivated polyacrylate dressings were used to treat acute and hard-to-heal wounds (the presence of Ringer's solution provides a wound dressing that allows, upon application, the immediate hydration of the underlying wound tissue). Method: Patients with acute and hard-to-heal wounds were enrolled into an open-labelled, non-comparative observational study. Patients were treated with Ringer's solution-preactivated polyacrylate dressings to enable wound debridement and wound cleansing for up to 12 weeks. Results: A total of 303 patients were enrolled in the study and 278 were included in the analysis. Wound size decreased, from a median of 3.6cm2 (interquartile range (IQR): 1.2–9.3] at baseline to a median of 2.6cm2 (IQR: 1.1–7.8] at 84 days. Relative wound area reduction (WAR) was 43.1% at 84 days and estimated probability of achievement of a WAR of ≥40% and ≥60% was 68.7% and 53.4%, respectively. Median time to achieve a WAR of ≥40% and ≥60% was 54 days and 75 days, respectively. The median percentage of wound area covered by fibrin had decreased from 50.0% to 10% and granulation tissue had increased from 25% to 50% after 84 days. In addition, periwound skin condition, local signs of infection and pain all showed improvement. The majority of the wounds were assessed as ‘healed’ or ‘better’ at the conclusion of the evaluation period. Conclusion: Based on the findings of this study, the use of Ringer's solution-preactivated polyacrylate dressings in daily practice has the potential to improve clinical outcomes, including healing, in patients with acute and hard-to-heal wounds.
Long term effectiveness of inactivated vaccine BBIBP-CorV (Vero Cells) against COVID-19 associated severe and critical hospitalization in Morocco
Authors: Belayachi Jihane , Obtel Majdouline , Mhayi Abdelkader , Razine Rachid , Abouqal Redouane 
Published: December 2022

Background
We provide national estimates of the real-world Vaccine effectiveness (VE) based on nationally available surveillance data. The study aimed to estimate the effectiveness of the inactivated Covid-19 vaccine BBIBP-CorV (Vero Cells) Sinopharm vaccine currently deployed in Morocco against SARS- CoV-2 severe disease/ hospitalization” within 9 months after vaccination.

Methods
We conducted a test-negative, case-control study among a population aged 18 years or older who were tested by rt-PCR for SARS-CoV-2 infection from February to October 2021 in Morocco. From the national laboratory COVID-19 database; we identified cases who were rt-PCR positive amongst severe and critical COVID-19 cases and controls who had a negative rt-PCR test for SARS-CoV-2. From the national vaccination register (NVR); individuals vaccinated with COVID-19 Vaccine (Vero Cell) and those unvaccinated were identified and included in the study. The linkage between databases was conducted for the study of Vaccination status based on the timing of the vaccine receipt relative to the SARS-CoV-2 rt-PCR test date. For each person, who tested positive for SARS-CoV-2, we identified a propensity score-matched control participant who was tested negative. We estimated vaccine effectiveness against SARS- CoV-2 severe disease/ hospitalization using conditional logistic regression.

Results
Among 12884 persons who tested positive and 12885 propensity score-matched control participants, the median age was 62 years, 47.2% of whom were female. As a function of time after vaccination of second dose vaccination, vaccine effectiveness during the first month was 88% (95% CI, 84–91), 87% (95% CI: 83–90) during the second and third month, 75% (95% CI: 67–80) during the fourth month, 61% (95% CI: 54–67) during the fifth month, and 64% (95% CI: 59–69) beyond the sixth month. VE remained high and stable during the first three months in the two-age subgroup. In the fourth month, the VE in the older population aged 60 years and above (64%) was reduced by 20 points compared to VE in the younger population (84%).

Conclusion
A Sinopharm vaccine is highly protective against serious SARS-CoV-2 infection under real-world conditions. Protection remained high and stable during the first three months following the second dose and decreases slightly beyond the fourth month especially beyond 60 years.
Dialética do Concreto
Authors: Richter Leonice Matilde 
Published: December 2022

A autora Leonice Matilde Richter, escreveu esta resenha baseada no livro "Dialética do Concreto", do autor Karel Kosik.
Referência:
RICHTER, Leonice Matilde. Clássico Marxista: “Dialética do concreto”. Revista Educação e Políticas em Debate, Uberlândia, v. 1, n.1, p. 236-248, 2012. [Seção] Resenha. Resenha da obra de: KOSIK, kAREL. Dialética do concreto. Rio de Janeiro: Paz e Terra, 2010. Disponível em: http://www.seer.ufu.br/index.php/revistaeducaopoliticas/article/view/17383
Ficção na passagem do século: imagens de mulheres e trabalho / Fiction in the turn of the century: images of women and work
Authors: Rincón Afonso Lúcia Helena , Carneiro Maria Esperança Fernandes 
Published: December 2022

Resumo:Este artigo trata de como as imagens de Mulher e Trabalho são apresentadas em telenovelas brasileiras na virada do século, gênero televisivo de grande apelo popular. As bases deste artigo encontram-se em uma tese doutoral. As imagens de mulher e trabalho apresentadas representam a inserção no espaço público como uma necessidade com características compatíveis com a sociedade da produção flexível. Palavras Chave: Telenovela, Imagens de Mulher, Trabalho e GeneroAbstract: This article deals with womenÂ´s images shown at the brazilian soap operas. Assuming that it has a great appeal among the Brazilian audience, the paper aims Â to discuss how the media representÂ these women in the turn of the century.Â The bases of this article can be found in a doctoral thesis. The images of women and work analyzed show the presence of women in the public space as a necessity that reflects the uncertainty and competitiveness of the flexible production society. Keywords: Soap opera. WomenÂ´s images.Â Work andÂ Gender.
POLÍTICAS EDUCACIONAIS E TRABALHO DOCENTE: PERSPECTIVA COMPARADA
Authors: Paiva Silvani Aparecida Ribeiro de 
Published: December 2022

O livro "Políticas educacionais e trabalho docente: perspectiva comparada" é uma coletânea de textos organizada por Dalila Andrade de Oliveira, Mônica Pini e Myriam Feldfeber, composta por nove Â capítulos, totalizando 215 páginas. O trabalho é derivado de estudos e pesquisas realizados nos dois últimos anos por uma equipe de profissionais composta por pesquisadores brasileiros e argentinos, por meio de um acordo firmado entre a Coordenação de Aperfeiçoamento Pessoal do Nível Superior (CAPES) do Brasil e o Ministério de Ciência e Tecnologia e Inovação Produtiva da República Argentina (MINCYT), que apoiaram o intercâmbio acadêmico através do Projeto "Nova regulação educativa na Argentina e no Brasil: perspectiva comparada". A obra possibilita ao leitor apreender os complexos processos de regulação educativa nos dois países, por meio de uma perspectiva analítica comparada, que se efetivou pela participação de seus pesquisadores, em cada recorte temático.
O FINANCIAMENTO DA EDUCAÇÃO DE QUALIDADE
Authors: Sena Paulo 
Published: December 2022

Resumo: Este artigo discute o financiamento da educação de qualidade a partir do entendimento de que a qualidade integra o núcleo essencial do direito Ã Educação. Analisa como financiamento e qualidade da educação estiveram presentes na legislação educacional brasileira até a inserção do conceito de padrão mínimo de qualidade e de sua relação com um valor por aluno. Discute a evolução para o conceito operacional custo aluno qualidade, calcado sobre os insumos necessários à educação de qualidade. Destaca que a meta 7 do PNE, embora adote a avaliação da qualidade orientada por resultados de desempenho em testes padronizados, medidos pelo Ideb, não abandonou a avaliação orientada por insumos em suas estratégias, de modo que dialoga com a meta 20 que consagrou o custo aluno qualidade. Aponta os desafios da execução do PNE para proporcionar o financiamento da educação de qualidade.
Singularity models of pinched solutions of mean curvature flow in higher codimension
Authors: Naff Keaton 
Published: December 2022

Abstract
We consider ancient solutions to the mean curvature flow in

R

n
+
1

\mathbb{R}^{n+1}

(

n
≥
3

n\geq 3

) that are weakly convex, uniformly two-convex, and satisfy two pointwise derivative estimates

|

∇
⁡
A

|

≤

γ
1

⁢

|
H
|

2

\lvert\nabla A\rvert\leq\gamma_{1}\lvert H\rvert^{2}

,

|

∇
2

⁡
A

|

≤

γ
2

⁢

|
H
|

3

\lvert\nabla^{2}A\rvert\leq\gamma_{2}\lvert H\rvert^{3}

.
We show that such solutions are noncollapsed.
As an application, in arbitrary codimension, we consider compact 𝑛-dimensional (

n
≥
5

n\geq 5

) solutions to the mean curvature flow in

R
N

\mathbb{R}^{N}

that satisfy the pinching condition

|
A
|

2

<

c
⁢

|
H
|

2

\lvert A\rvert^{2}<c\lvert H\rvert^{2}

for a suitable constant

c
=

c
⁢

(
n
)

c=c(n)

.
We conclude that any blow-up model at the first singular time must be a codimension one shrinking sphere, shrinking cylinder, or translating bowl soliton.
The effect of nonadherence on phenobarbital concentrations and recommendations on the replacement dose using Monte Carlo simulation
Authors: Methaneethorn Janthima 
Published: December 2022

Abstract

Objectives
To determine the impacts of missed phenobarbital (PB) doses on its pharmacokinetics and to investigate the appropriate replacement dosing scheme for various PB missed dose scenarios.

Methods
Monte Carlo simulations were performed using parameters from the selected population pharmacokinetic study. The impacts of missed PB dose and the proper replacement dosing scheme were assessed based on the percent deviation of simulated concentrations outside the reference range from the full adherence scenario.

Results
The impact of missed PB dose on its concentrations depended on the daily dose. The replacement with a respective regular dose and one and a half regular dose was appropriate for the one and two missed doses scenarios for patients receiving PB monotherapy. For patients receiving PB with valproic acid or phenytoin, the same replacement scheme was still appropriate. The results also indicated that weight did not influence the proper replacement dosing scheme.

Conclusions
The impacts of missed PB doses on its pharmacokinetics were identified and the proper replacement dosing schemes for different missed dose scenarios were proposed. These schemes should be implemented based on the clinician’s justification of the patient’s seizure control.
Innovative high-speed method for detecting hotspots in high-density solar panels by machine vision
Authors: Yazdani Hassan , Radmehr Mehdi , Ghorbani Alireza 
Published: December 2022

Abstract
The occurrence of hotspots in photovoltaic panels is one of the most common problems of solar power plants, which reduces the output power of photovoltaic arrays and can also cause irreparable damage to the solar cells. There are several ways to identify hotspots, including using custom datasets using thermographic camera images, which will be later used to teach YOLO and Faster R-CNN computer vision algorithms. In practice, it is observed that the YOLO algorithm is many times faster than the Faster R-CNN in high-density solar panels. Therefore, the applied method is the safest choice for automatic hotspot detection in large-scale photovoltaic power plants to improve overall efficiency. In this paper, by comparing the performance of methods such as Faster R-CNN with YOLO, we concluded that the YOLO algorithm has far better advantages in terms of quality of detection, and speed. Therefore, this factor makes the use of YOLO significantly helps to speed up the troubleshooting of solar modules caused by hotspots, and this factor improves the efficiency of solar power plants in the long run. Meanwhile, in the studies for this paper, the results extracted by Python have been optimized as an algorithm to be used for hotspot detection.