bluuebunny/crossref_metadata_2025_split huggingface dataset:
A proof-of-concept study on the use of a fluorescein-based 18F-tracer for pretargeted PET
Authors: Helbert Hugo , Ploeg Emily M. , Samplonius Douwe F. , Blok Simon N. , Antunes Ines F. , Böhmer Verena I. , Luurtsema Gert , Dierckx Rudi A. J. O. , Feringa Ben L. , Elsinga Philip H. , Szymanski Wiktor , Helfrich Wijnand 
Published: March 2022

Abstract
Background
Pretargeted immuno-PET tumor imaging has emerged as a valuable diagnostic strategy that combines the high specificity of antibody-antigen interaction with the high signal and image resolution offered by short-lived PET isotopes, while reducing the irradiation dose caused by traditional 89Zr-labelled antibodies. In this work, we demonstrate proof of concept of a novel ‘two-step’ immuno-PET pretargeting approach, based on bispecific antibodies (bsAbs) engineered to feature dual high-affinity binding activity for a fluorescein-based 18F-PET tracer and tumor markers.

Results
A copper(I)-catalysed click reaction-based radiolabeling protocol was developed for the synthesis of fluorescein-derived molecule [18F]TPF. Binding of [18F]TPF on FITC-bearing bsAbs was confirmed. An in vitro autoradiography assay demonstrated that [18F]TPF could be used for selective imaging of EpCAM-expressing OVCAR3 cells, when pretargeted with EpCAMxFITC bsAb. The versatility of the pretargeting approach was showcased in vitro using a series of fluorescein-binding bsAbs directed at various established cancer-associated targets, including the pan-carcinoma cell surface marker EpCAM, EGFR, melanoma marker MCSP (aka CSPG4), and immune checkpoint PD-L1, offering a range of potential future applications for this pretargeting platform.

Conclusion
A versatile pretargeting platform for PET imaging, which combines bispecific antibodies and a fluorescein-based 18F-tracer, is presented. It is shown to selectively target EpCAM-expressing cells in vitro and its further evaluation with different bispecific antibodies demonstrates the versatility of the approach.
Role of phytochemicals as potential radioprotectants
Authors: Chavhan Sarin A. , Bakal Ravindra L. , Jawarkar Rahul D. , Gandhi Roshani P. , Chandak Mayuri P. , Lewaa Israa 
Published: March 2022

Abstract
Background
Ionizing radiations causes harm to living organisms and the rapid technological progress has increased human exposure to ionizing radiations enormously. Ionizing radiations come in contact with exposure from space radiations, nuclear war, and radiotherapy for cancer-like disease.

Main body of the abstract
There is a need for human beings against these effects of ionizing radiation due to lack of safe and effective radiation available so far, and the traditional medicines used from ancient times of different disease and protection against radiation. A systematic in vivo and in vitro study may use to identify a new lead compound as a radiation shielding agent. The radioprotective properties of plant and herbal extracts, as well as their radioprotective doses, are highlighted in this article. The outcomes of the in vitro and in vivo studies indicate that several botanicals such as Gingko biloba, Centella asiatica, Ocimum sanctum, Panax ginseng, Emblica officinalis, Phyllanthus amarus, Piper longum, Tinospora cordifoila, Mentha arvensis, Mentha piperita, Syzygium cumini, Zingiber officinale, Ageratum conyzoides, Aegle marmelos and Piper betle protect against radiation-induced lethality, lipid peroxidation, and DNA damage.

Short conclusion
The fractionation-guided evaluation may help to develop new radioprotectors for targeted activities.
Phenological and physiological responses of hybrid rice under different high-temperature at seedling stage
Authors: Aryan Shafiqullah , Gulab Gulbuddin , Habibi Nasratullah , Kakar Kifayatullah , Sadat Mohammad Ismail , Zahid Tayebullah , Rashid Rashid Ahmad 
Published: March 2022

Abstract
Background
The projected increase in global temperature is expected to negatively impact food production in many regions. Rice exposure to heat stress can limit plant growth in different stages, especially at the seedling stage. In this experiment, two Indica parental lines N22 (heat tolerant) and BIM (heat sensitive) along with their F2 hybrid were elucidated under different high temperatures (28 °C, 35 °C, and 42 °C) at the seedling stage.

Results
The results indicated that the F2 hybrid inherited the heat tolerance rate from the male heat-tolerant N22 parent. Based on phenological and physiological attributes, the F2 hybrid exhibited excessive-performance as compared to its BIM parent under different high-temperature conditions. Specifically, absorbing the ample available water through the long-rooted system enabled rice seedlings to carry out high transpirational cooling. Furthermore, there was a strong relationship (r = 0.89, p < 0.01) between root length and transpiration rate under 42 °C. The temperature 35–42 °C caused a significant reduction in seedlings’ growth, chlorophyll content, and survival rate (18–20%), while the relative heat injury percentage and leaf temperature increased in heat-sensitive BIM parent as compared to F2 hybrid.

Conclusion
This study suggests that the breeding of heat-tolerant hybrid rice plays an important role in the production of a resilient rice plant through heat-tolerant seedlings at the initial vegetative growth stage.
Identifying high-risk over-entitlement in access control policies using fuzzy logic
Authors: Parkinson Simon , Khana Saad 
Published: March 2022

AbstractAnalysing access control policies is an essential process for ensuring over-prescribed permissions are identified and removed. This is a time-consuming and knowledge-intensive process, largely because there is a wealth of policy information that needs to be manually examined. Furthermore, there is no standard definition of what constitutes an over-entitled permission within an organisation’s access control policy, making it not possible to develop automated rule-based approaches. It is often the case that over-entitled permissions are subjective to an organisation’s role-based structure, where access is be divided and managed based on different employee needs. In this context, an irregular permission could be one where an employee has frequently changed roles, thus accumulating a wide-ranging set of permissions. There is no one size fits all approach to identifying permissions where an employee is receiving more permission than is necessary, and it is necessary to examine them in the context of the organisation to establish their individual risk. Risk is not a binary measure and, in this work, an approach is built using Fuzzy Logic to determine an overall risk rating, which can then be used to make a more informed decision as to whether a user is over-entitled and presenting risk to the organisation. This requires the exploratory use of establishing resource sensitivity and user trust as measures to determine a risk rating. The paper presents a generic solution, which has been implemented to perform experimental analysis on Microsoft’s New Technology File System to show how this works in practice. A simulation using expert knowledge for comparison is then performed to demonstrate how effective it is at helping the user identify potential irregular permissions.
Relationship between work–family conflict, sleep quality, and depressive symptoms among mental health nurses
Authors: Mohamed Bothina Elsayed Said , Ghaith Rehab Fathy Abdel Hady , Ahmed Hanem Ahmed AbdElkhalek 
Published: March 2022

Abstract
Background
Nursing has a reputation for being one of the most stressful occupations. As a result of their work, many nurses suffer from anxiety and depression. Nurses are also at risk of poor sleep owing to their work nature. This study aimed to examine the relationship between work–family conflict, sleep quality, and depressive symptoms among mental health nurses. A descriptive cross-sectional study design was utilized in this study. Setting/sample: This study was conducted at El Azazi Hospital for Mental Health, Al-Sharkia Governorate on 139 mental health nurses. Four tools were used in this study: Socio-demographic data sheet, Work–Family Conflict Scale, Arabic Pittsburgh Sleep Quality Index, and Arabic Center for Epidemiologic Studies Depression Scale.

Results
Results revealed that, a significant percentage of mental health nurses suffered from poor sleep quality and depressive symptoms, there were highly statistically significantly positive correlations between work–family conflict (WFC) and both of Pittsburgh Sleep Quality Index (PSQI) and depressive symptoms among nurses.

Conclusions
Working with psychiatric patients affected their nurses, which disturbed their sleep quality and led to depressive symptoms. As well, increasing work–family conflict in mental health nurses leads to poor sleep quality and depressive symptoms. Family interference with work, sleep quality, and work interference with family were statistically significant predictors of depressive symptoms.
Barriers and facilitative factors in the implementation of workplace health promotion activities in small and medium-sized enterprises: a qualitative study
Authors: Saito Junko , Odawara Miyuki , Takahashi Hirokazu , Fujimori Maiko , Yaguchi-Saito Akiko , Inoue Manami , Uchitomi Yosuke , Shimazu Taichi 
Published: March 2022

Abstract
Background
There is an immense difference between large companies and small and medium-sized enterprises (SMEs) in implementation of evidence-based interventions (EBIs). Previous literature reveals various barriers that SMEs face during implementation, such as a lack of time, accessibility, and resources. However, few studies have comprehensively examined those influential factors at multi-levels. This study aims to identify the factors influencing the implementation of non-communicable disease prevention activities (tobacco, alcohol, diet, physical activity, and health check-up) in SMEs using Consolidated Framework for Implementation Research (CFIR).

Methods
We conducted 15 semi-structured interviews with health managers and/or employers in 15 enterprises with less than 300 employees, and four focus groups among public health nurses/nutritionists of health insurers who support SMEs in four prefectures across Japan. A qualitative content analysis by a deductive directed approach was performed. After coding the interview transcript text into the CFIR framework constructs by two independent researchers, the coding results were compared and revised in each enterprise until an agreement was reached.

Results
Of the 39 CFIR constructs, 25 were facilitative and 7 were inhibitory for workplace health promotion implementation in SMEs, which were across individual, internal, and external levels. In particular, the leadership engagement of employers in implementing the workplace health promotion activities was identified as a fundamental factor which may influence other facilitators, including “access to knowledge and information,” “relative priority,” “learning climate,” at organizational level, and “self-efficacy” at the health manager level. The main barrier was the beliefs held by the employer/manager that “health management is one’s own responsibility.”

Conclusions
Multi-level factors influencing the implementation of non-communicable diseases prevention activities in SMEs were identified. In resource-poor settings, strong endorsement and support, and positive feedback from employers would be important for health managers and employees to be highly motivated and promote or participate in health promotion. Future studies are needed to develop context-specific strategies based on identified barriers and facilitative factors, and empirically evaluate them, which would contribute to narrowing the differences in worksite health promotion implementation by company size.
Detection of surface defects and subsurface defects of polished optics with multisensor image fusion
Authors: Sun Huanyu , Wang Shiling , Hu Xiaobo , Liu Hongjie , Zhou Xiaoyan , Huang Jin , Cheng Xinglei , Sun Feng , Liu Yubo , Liu Dong 
Published: March 2022

AbstractSurface defects (SDs) and subsurface defects (SSDs) are the key factors decreasing the laser damage threshold of optics. Due to the spatially stacked structure, accurately detecting and distinguishing them has become a major challenge. Herein a detection method for SDs and SSDs with multisensor image fusion is proposed. The optics is illuminated by a laser under dark field condition, and the defects are excited to generate scattering and fluorescence lights, which are received by two image sensors in a wide-field microscope. With the modified algorithms of image registration and feature-level fusion, different types of defects are identified and extracted from the scattering and fluorescence images. Experiments show that two imaging modes can be realized simultaneously by multisensor image fusion, and HF etching verifies that SDs and SSDs of polished optics can be accurately distinguished. This method provides a more targeted reference for the evaluation and control of the defects of optics, and exhibits potential in the application of material surface research.
Determination of near-surface shear-velocity structure based on the joint inversion of Rayleigh-wave dispersion and ellipticity from multistation active-seismic records
Authors: Xu Hongrui , Yin Xiaofei , Qi Qiaomu , Mi Binbin , Sun Shida , Luo Yinhe 
Published: March 2022

The dispersive characteristics of high-frequency (≥2 Hz) Rayleigh waves have been widely applied to determine subsurface shear velocity ([Formula: see text]). However, the [Formula: see text] of the high-velocity surface layers (e.g., rigid roads in urban areas) and underlying layers is poorly constrained in the Rayleigh-wave dispersion inversion. Compared to the phase velocity, the Rayleigh-wave horizontal-to-vertical (H/V) ratios of particle motion (i.e., ellipticity) are particularly sensitive to shallow [Formula: see text] structures. Therefore, we have proposed a robust method for obtaining near-surface [Formula: see text] structures by inverting Rayleigh-wave dispersion and H/V data. Initially, we separate the fundamental-mode Rayleigh waves from the active-seismic records using a high-resolution linear Radon transformation method. Then, we extract the high-frequency H/V and interstation phase traveltimes from the separated fundamental mode using deconvolution interferometry and the frequency-time analysis method. Based on the phase traveltimes, we calculate the phase velocity dispersion using ray-based tomography. Finally, we perform the joint inversion of dispersion and H/V data to obtain the [Formula: see text] structure. According to the inversion results of synthetic and field data, the accuracy of the [Formula: see text] in the rigid surface layer and underlying layers is considerably improved. We find that the joint inversion of Rayleigh-wave phase velocity dispersion and H/V data from surface-wave surveys is a useful tool for accurately determining the complex shallow [Formula: see text] structures.
With, Without, Even Still: Frederick Douglass,L’Union, and Editorship Studies
Authors: Casey Jim , Salter Sarah H. 
Published: March 2022

AbstractThis essay calls for the concerted study of editorship as a distinct mode of cultural expression. Given that the collaborative craft of editors is often invisible, the study of editorship requires attending to the practices, habits, and techniques of editing as themselves historically contingent and significant objects of inquiry. This essay analyzes a cross section of editorial practices in 1862 when a controversy during the Civil War over slavery and emancipation entangled editors from Horace Greeley and Frederick Douglass to their less conspicuous peers at L’Union (a bilingual, Black Creole weekly in New Orleans). These examples reveal the practical language of editorship expressed through serial formats. By reading editing on its own terms, in the patterns of established formats and formal innovations, it becomes possible to envision the broader study of editorship not only for nineteenth-century Black, Latinx, Indigenous, and multilingual print cultures but also in the wider firmaments of literary and cultural history.
From Sexual Harassment to Gender Violence at Work: The ILO's Road to Convention #190
Authors: Boris Eileen 
Published: March 2022

AbstractThis article considers the political, social, and institutional forces behind the ILO's “Violence and Harassment Convention, 2019 (No. 190).” It traces the competing terms—worker protection, women's equality, and human rights—by which sexual harassment emerged as a proper subject for international action and how violence became the most acceptable framework for redress. With the plight of domestic workers dramatizing the issue, it took concerted efforts of women in the international labor movement, along with feminist staff within the ILO and key delegates to its International Labour Conference, to win a new labor standard.
Retreatment Strategies in Aneurysm Woven Endobridge Recurrences: A Case Series
Authors: Abbas Rawad , El Naamani Kareem , Sweid Ahmad , Birkenstock Lyena , Ruiz Ramon , Tjoumakaris Stavropoula , Gooch M. Reid , Herial Nabeel A. , Rosenwasser Robert H. , Jabbour Pascal 
Published: March 2022

BACKGROUND:
The treatment of wide-necked and bifurcation aneurysms has become a common indication for the Woven Endobridge (WEB) device. In many instances, WEB embolization fails and retreatment strategies for the recanalized aneurysms have not been established and may be challenging.

OBJECTIVE:
To report an experience with retreatment strategies after WEB failure in 7 cases involving various aneurysm shapes, sizes, and location using multiple strategies including endovascular modalities and microsurgical clip ligation.

METHODS:
Data were retrospectively collected from 1 high-volume cerebrovascular center for 7 patients treated with a WEB device for an aneurysm who subsequently required retreatment for that same aneurysm from 2015 through January 2021.

RESULTS:
We identified 7 patients with WEB recurrences over a period of 6 years. Four patients initially presented with incidental findings, whereas 3 patients presented with subarachnoid hemorrhage. One patient was lost to follow-up and presented with a rerupture, whereas the 6 other patients were diagnosed with routine follow-up. Two patients received clip ligation, 2 had simple coil embolization, 1 had stent-assisted coil embolization, 1 had a flow-diverting stent, and 1 patient required 2 retreatments; he received stent-assisted coil embolization for the first retreatment and a simple coil embolization for the second retreatment. All patients had excellent angiographic outcomes and no complications.

CONCLUSION:
The authors conclude that aneurysm recurrence after WEB is very diverse, and no single modality can properly address all recurrences. Rather, an individualized approach based on aneurysm features, neurointerventionalist expertise, and patient preference should be implemented.
DNMT1 is a negative regulator of osteogenesis
Authors: Tao Chen , Liu Jia , Li Ziqi , Lai Pinglin , Zhang Sheng , Qu Jiankun , Tang Yujin , Liu Anling , Zou Zhipeng , Bai Xiaochun , Li Jianwei 
Published: March 2022

ABSTRACT
The role and underlying mechanisms of DNA methylation in osteogenesis/chondrogenesis remain poorly understood. We here reveal DNA methyltransferase 1 (DNMT1), which is responsible for copying DNA methylation onto the newly synthesized DNA strand after DNA replication, is overexpressed in sponge bone of people and mice with senile osteoporosis and required for suppression of osteoblast (OB) differentiation of mesenchymal stem cells (MSCs) and osteoprogenitors. Depletion of DNMT1 results in demethylation at the promoters of key osteogenic genes such as RORA and Fgfr2, and consequent upregulation of their transcription in vitro. Mechanistically, DNMT1 binds exactly to the promoters of these genes and are responsible for their 5-mc methylation. Conversely, simultaneous depletion of RORA or Fgfr2 blunts the effects of DNMT1 silencing on OB differentiation, suggesting RORA or Fgfr2 may be crucial for modulating osteogenic differentiation downstream of DNMT1. Collectively, these results reveal DNMT1 as a key repressor of OB differentiation and bone formation while providing us a new rationale for specific inhibition of DNMT1 as a potential therapeutic strategy to treat age-related bone loss.
Dynamic contrast-enhanced MRI can quantitatively identify malignant transformation of sinonasal inverted papilloma
Authors: Li Zheng , Xian Mu , Guo Jian , Wang Cheng shuo , Zhang Luo , Xian Junfang 
Published: March 2022

Objective:
To investigate the diagnostic performance of quantitative and semi-quantitative parameters derived from dynamic contrast-enhanced MRI (DCE-MRI) in differentiating sinonasal inverted papilloma (SIP) from SIP with coexisting malignant transformation into squamous cell carcinoma (MT-SIP).

Methods:
This retrospective study included 122 patients with 88 SIP and 34 MT-SIP. Quantitative and semi-quantitative parameters derived from DCE-MRI were compared between SIP and MT-SIP. The multivariate logistic regression analysis was performed to identify independent indicators and construct regression model for distinguishing MT-SIP and SIP. Diagnostic performance of independent indicators and regression model were evaluated using receiver operating coefficient (ROC) analysis and compared using DeLong test.

Results:
There were significant differences in maximum slope of increase, contrast-enhancement ratio, bolus arrival time, volume of extravascular extracellular space (Ve), and rate constant (Kep) between SIP and MT-SIP (p &lt; 0.05). There were no significant differences in initial area under the gadolinium curve (p = 0.174) and volume transfer constant (p = 0.105) between two groups. Multivariate analysis results showed that Ve and Kep were identified as the independent indicators for differentiating MT-SIP from SIP (p &lt; 0.001). Areas under the ROC curves (AUCs) for predicting MT-SIP were 0.779 for Ve and 0.766 for Kep. The AUC of the combination of Ve and Kep was 0.831, yielding 83% specificity and 76.5% sensitivity.

Conclusion:
DCE-MRI can quantitatively differentiate between MT-SIP and SIP. The combination of Ve and Kep yielded an optimal performance for discriminating SIP from its malignant mimics.

Advances in knowledge:
DCE-MRI with quantitative and semi-quantitative parameters can provide valuable evidences for quantitatively identifying MT-SIP.