bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baseline Clinical and Neuroimaging Biomarkers of Treatment Response to High-Frequency rTMS Over the Left DLPFC for Resistant Depression
Authors: Harika-Germaneau Ghina , Wassouf Issa , Le Tutour Tom , Guillevin Remy , Doolub Damien , Rostami Reza , Delbreil Alexia , Langbour Nicolas , Jaafari Nematollah 
Published: May 2022

BackgroundRepetitive transcranial magnetic stimulation (rTMS) has proven to be an efficient treatment option for patients with treatment-resistant depression (TRD). However, the success rate of this method is still low, and the treatment outcome is unpredictable. The objective of this study was to explore clinical and structural neuroimaging factors as potential biomarkers of the efficacy of high-frequency (HF) rTMS (20 Hz) over the left dorso-lateral pre-frontal cortex (DLPFC).MethodsWe analyzed the records of 131 patients with mood disorders who were treated with rTMS and were assessed at baseline at the end of the stimulation and at 1 month after the end of the treatment. The response is defined as a 50% decrease in the MADRS score between the first and the last assessment. Each of these patients underwent a T1 MRI scan of the brain, which was subsequently segmented with FreeSurfer. Whole-brain analyses [Query, Design, Estimate, Contrast (QDEC)] were conducted and corrected for multiple comparisons. Additionally, the responder status was also analyzed using binomial multivariate regression models. The explored variables were clinical and anatomical features of the rTMS target obtained from T1 MRI: target-scalp distance, DLPFC gray matter thickness, and various cortical measures of interest previously studied.ResultsThe results of a binomial multivariate regression model indicated that depression type (p = 0.025), gender (p = 0.010), and the severity of depression (p = 0.027) were found to be associated with response to rTMS. Additionally, the resistance stage showed a significant trend (p = 0.055). Whole-brain analyses on volume revealed that the average volume of the left part of the superior frontal and the caudal middle frontal regions is associated with the response status. Other MRI-based measures are not significantly associated with response to rTMS in our population.ConclusionIn this study, we investigated the clinical and neuroimaging biomarkers associated with responsiveness to high-frequency rTMS over the left DLPFC in a large sample of patients with TRD. Women, patients with bipolar depressive disorder (BDD), and patients who are less resistant to HF rTMS respond better. Responders present a lower volume of the left part of the superior frontal gyrus and the caudal middle frontal gyrus. These findings support further investigation into the use of clinical variables and structural MRI as possible biomarkers of rTMS treatment response.
Gastric Negative Pressure Suction Method Reduces the Incidence of PONV after Orthognathic Surgery
Authors: Wang Jia , Zhang Zhenzhen 
Published: May 2022

ObjectiveTo investigate the effect of gastric negative pressure suction on the incidence of postoperative nausea and vomiting (PONV) in patients undergoing orthognathic surgery.MethodsA retrospective study of 772 patients who underwent orthognathic surgery from October 2016 to January 2021 was performed, excluding possible confounding factors. The patients were divided into a negative gastric suction group (group 1) and a group without gastric suction (group 2), according to whether gastric suction was used after general anaesthesia. There were 386 patients in each group. The incidence of PONV was compared between the two groups.ResultsThe incidence of PONV was 29% in the negative gastric suction group and 58.8% in the non-gastric suction group. The incidence of PONV in the gastric negative pressure suction group was significantly lower than that in the non-gastric negative pressure suction group, and the difference was statistically significant (p &lt; 0.05).ConclusionBy reducing the risk of perioperative bleeding in orthognathic surgery, gastric negative pressure aspiration can reduce the incidence and operation time of PONV after orthognathic surgery.
Aurintricarboxylic Acid Suppresses Hepatitis B Virus Replication by Inhibition of RNase H Activity
Authors: Xu Meng , Guan Xiao 
Published: May 2022

BackgroundChronic hepatitis B virus (HBV) infection is a global health threat for which there is an urgent need to develop novel therapeutics.MethodsAurintricarboxylic acid (ATA) has been demonstrated with broad-spectrum antimicrobial and antiviral activities. In this study, we implemented ATA treatment in HBV-infected and HBV-transfected hepatocytes to uncover whether ATA inhibits HBV replication and its underlying mechanism.ResultsHBV DNA levels were significantly reduced, while viral proteins or transcripts were not altered. In contrast, ATA treatment did not further deteriorate HBV DNAs, viral proteins, and transcripts in hepatocytes transfected by an HBV RNase H dead mutant. Moreover, ATA showed an inhibitory effect on DNA synthesis in hepatocytes transfected with lamivudine-resistant HBV mutants.ConclusionsATA is a potent inhibitor of HBV replication by disrupting the RNase H activity of the viral polymerase.
Changes in Obesity Prevalence Attributable to Ultra-Processed Food Consumption in Brazil Between 2002 and 2009
Authors: Louzada Maria Laura , Steele Eurídice Martinez , Rezende Leandro F. M. , Levy Renata Bertazzi , Monteiro Carlos Augusto 
Published: May 2022

Objectives: To quantify the impact of temporal changes in the consumption of ultra-processed foods on obesity trends in Brazil between 2002 and 2009.Methods: We analyzed data from two Household Budget Surveys carried out in 2002/2003 (n = 182,333) and 2008/2009 (n = 190,159), which provided information on household food acquisition and individuals’ weight and height. We examined the association between ultra-processed foods consumption and obesity and quantified the fraction of increase in obesity prevalence attributable to the rise in the consumption of ultra-processed foods.Results: From 2002 to 2009, there was an increase in the obesity prevalence from 9.9% (95% CI 9.3; 10.4) to 13.2% (12.8; 13.7) while the contribution of ultra-processed foods to total energy consumption raised from 14.3% (13.4; 15.1) to 17.3% (16.5; 18.1). Ultra-processed foods consumption was positively associated with obesity prevalence. More than one quarter (28.6%) of the increase in obesity prevalence was attributable to the rise in the consumption of ultra-processed foods in the period.Conclusion: We found that the rise in the consumption of ultra-processed foods played a major role on the increase of obesity epidemic in Brazil.
Habitat Associations of Overwintering Bats in Managed Pine Forest Landscapes
Authors: Andersen Brett R. , McGuire Liam P. , Wigley Thomas Bently , Miller Darren A. , Stevens Richard D. 
Published: May 2022

Research Highlights: Seasonal variation in environmental conditions coinciding with reproductive and energetic demands might result in seasonal differences in species-specific habitat use. We studied a winter assemblage of insectivorous bats and found that species acted as habitat generalists during winter compared to expectations based on the summer active season. Background and Objectives: In temperate regions, seasonal fluctuations in resource availability might restructure local bat assemblages. Initially perceived to only hibernate or migrate to avoid adverse winter conditions, temperate insectivorous bats appear to also employ intermediate overwintering strategies, as a growing body of literature suggests that winter activity is quite prevalent and even common in some lower latitude areas. However, to date, most studies have exclusively assessed habitat associations during summer. Because habitat use during summer is strongly influenced by reproduction, we hypothesized that habitat associations might differ during the non-reproductive winter period. We used acoustic monitoring to assess the habitat associations of bats across a managed pine landscape in the southeastern United States. Materials and Methods: During the winters of 2018 and 2019, we deployed acoustic detectors at 72 unique locations to monitor bat activity and characterized vegetation conditions at two scales (microhabitat and landscape). We used linear mixed models to characterize species-specific activity patterns associated with different vegetation conditions. Results: We found little evidence of different activity patterns during winter. The activity of three species (hoary bat: Lasiurus cinereus; southeastern myotis: Myotis austroriparius; and tricolored bat: Perimyotis subflavus) was not related to vegetation variables and only modest relationships were evident for four other species/groups (big brown bat: Eptesicus fuscus; eastern red bat: L. borealis; Seminole bat: L. seminolus; evening bat: Nycticeius humeralis; and Brazilian free-tailed bat: Tadarida brasiliensis). Conclusions: During winter, the bats in our study were active across the landscape in various cover types, suggesting that they do not exhibit the same habitat associations as in summer. Therefore, seasonal differences in distributions and habitat associations of bat populations need to be considered so that effective management strategies can be devised that help conserve bats year round.
FUTURE FINE ARTS TEACHERS’ PROFESSIONALISM FORMATION IN THE DEPARTMENT CULTURAL AND EDUCATIONAL SPACE
Authors: Saienko T. , Batiievska T. , Mokhirieva Yu. 
Published: May 2022

The article defines and characterizes the pedagogical conditions for the future fine arts teachers’ professionalism formation in cultural and educational space of the department. These conditions are the following: compliance of lecturers’ basic education with department profile; organization lecturers’ artistic and creative activity and the process of motivating students to perform the above-mentioned activity; lecturers’ scientific activity and involvement of students in research and innovation activities. It is proved that teaching, scientific and artistic activity of the lecturers of the Department of Fine Arts of Poltava V. G. Korolenko National Pedagogical University is the basis of the department cultural and educational space. It is carried out at the level of modern higher education and allows carrying out professional training of specialists in the educational-professional program ‘Secondary Education (Fine Arts).
NON-FORMAL MUSIC EDUCATION ORGANIZATION IN OUT-OF-SCHOOL INSTITUTIONS
Authors: Myroshnychenko V. 
Published: May 2022

The article reveals the importance of non-formal music education in out-of-school institutions. It is noted that non-formal music education is a certain artistic movement and a socially organized community of people who are united by common artistic interests, goals, and joint musical activities.
The use of different forms of organization of non-formal art education in extracurricular institutions is conditioned by the type of art, namely non-formal musical educational activity is carried out in choral groups (folk, chamber), vocal ensembles (folk, vocal and instrumental), in individual vocal performance, instrumental duets, trios, ensembles or orchestras (folk instruments, bandura players, etc.) and various temporary creative music groups.
The advantages of using informal music education in an extracurricular institution are its mobility, flexibility, the use of alternative forms of learning, and the formation of additional skills.
TRAINING FUTURE PRIMARY SCHOOL TEACHER AT POLTAVA V. G. KOROLENKO NATIONAL PEDAGOGICAL UNIVERSITY FOR DEMOCRATIC CITIZENSHIP EDUCATION
Authors: Pogrebnyak V. 
Published: May 2022

The scientific and pedagogical basis of the special training course “Forming Democratic Citizenship of a Primary School Teacher-to-Be in the System of Higher Pedagogical Education” at Poltava V. G. Korolenko National Pedagogical University is revealed and its content has been developed. The prognostic results of studying the discipline as means of realization of democratic principles in the pedagogical process of teacher training in the conditions of renewal of Ukrainian society and growth of public activity are determined.
Studying the educational discipline is aimed at mastering by teachers-to-be the historical and pedagogical principles of becoming and presenting citizenship education in the world educational systems in the context of civilizational development of humanity; learning theoretical positions of civil education: essence, pedagogical importance, purpose, tasks, and principles; to become proficient at methodical bases and tools (forms, methods, facilities) of realization of tasks of democratic citizenship education in the pedagogical process.
From Happy Wedding to Divorce; Marriage Terms Metaphor in Indonesian Political Coalition
Authors: Adam Muhammad , Hafsah Siti 
Published: May 2022

: Indonesian political multi-parties system requires political parties to build a solid coalition in anticipating any election event, at all levels; national, regional, and local. The description of the way political parties build the relationship and how candidates seek support from a party is often described metaphorically as stages of marriage. There are few studies of metaphor in political discourse in the Indonesian context, but less attention is given to the detail of the use of the specific source domain MARRIAGE. This study aims to take a deeper look at how the marriage relationship context is used to describe the conceptual metaphor of political coalition establishment. The aim of this study is to identify the mapping principle from the Source domain of MARRIAGE to the target domain POLITICAL COALITION to pinpoint the particular properties that enable characteristics in MARRIAGE to be used as the metaphorical expressions. Conceptual Metaphor Theory (CMT) of Lakoff and Johnson (1980) and Deliberate Metaphor Theory of Steen, (2011) are used as the theoretical framework, with six news headlines about the political coalition from Indonesian online media news is purposively chosen as the data source.
QUAND LES FEMMES PRENNENT LES ARMES : L’ÉCRITURE DE LA VIOLENCE FÉMININE DANS LA FANTASY MÉDIÉVALISANTE
Authors: Simon Cassandra , Geslin Antoine 
Published: May 2022

Au regard des nombreuses œuvres du genre, la fantasy médiévalisante et la violence semblent intrinsèquement liées au travers des enjeux de pouvoir et de domination qui caractérisent les structures sociales et les relations interpersonnelles mises en texte par le récit. Bien que la violence soit traditionnellement rattachée à la masculinité, la multiplication de combattantes dans les fictions contemporaines annonce sa féminisation. L’étude du roman de Manon Fargetton, Les Illusions de Sav-Loar, nous permet cependant de repérer une tension dans la violence féminine, dont la représentation ne va jamais de soi. Soumise au cadre du patriarcat, la violence des femmes est subordonnée à celle des hommes et sa légitimation dépend des modalités de son expression. La vengeance et l’autodéfense, en tant qu’actes isolés et individuels, sont ainsi approuvées par le texte tandis que la violence révolutionnaire qui vise à transformer l’organisation de la société subit la condamnation de la narration et des protagonistes du récit. Finalement, Les Illusions de Sav-Loar suggèrent que le véritable pouvoir féminin se situe dans la non-violence, plus proche de la nature féminine pacifique et maternelle, comme réponse ultime et conciliatrice à la domination brutale des hommes : les combattantes troquent alors le glaive contre l’enfant.
Caracterización clínica y epidemiológica de recién nacidos con síndrome de aspiración meconial
Authors: Sosa Duque Ana Lucrecia 
Published: May 2022

OBJETIVO: describir las características clínicas y epidemiológicas de los recién nacidos con síndrome de aspiración meconial ingresados a unidad de cuidados intensivos pediátricos en el Hospital Nacional de Chiquimula en los meses de mayo a julio del 2021 MÉTODO: se realizó un estudio descriptivo transversal en donde se colectó por medio de entrevistas y expedientes clínicos la información sobre los recién nacidos con el diagnóstico de síndrome de aspiración meconial ingresados a unidad de cuidados intensivos RESULTADOS: de los recién nacidos evaluados se valoró que la edad gestacional por Capurro más frecuente fue de 39 semanas (35%), 66% de los pacientes nacieron por parto eutócico simple. 82% presentaron complicaciones, específicamente, choque séptico (44%), neumonitis química (20%) e hipertensión pulmonar persistente (18%). CONCLUSIÓN: de las 60 madres en estudio el grupo etario que predominó fue el de 26 a 30 años con el 30%, el 77% pertenecían al área rural, la comorbilidad más frecuente fue preeclampsia con 31% y el factor de riesgo multípara con un 35%. Se identificó que el 66% de neonatos nacieron por parto eutócico simple, 42% obtuvieron una puntuación de APGAR normal al primer minuto y 67% de los pacientes egresaron con éxito del servicio.
Photodissociation Rate, Excess Energy, and Kinetic Total Energy Release for the Photolysis of H2O Producing O(1S) by Solar UV Radiation Field
Authors: Kawakita Hideyo 
Published: May 2022

Abstract
Forbidden atomic oxygen lines in emission are ubiquitous for cometary spectra in the visible region, and the oxygen atoms in metastable states causing the forbidden emission lines are considered as a proxy of H2O in coma. However, the photodissociation rate and related quantities for the dissociation reaction producing O(1S) from H2O have never been estimated based on experimental studies. Based on the recent laboratory study of the photodissociation reaction of H2O producing O(1S) by Chang et al., we derived the photodissociation rates of the reactions for both the O(1S) and O(1D) channels, consistent with the green-to-red line ratios observed in comets so far. Furthermore, the total kinetic energies released for the photodissociation products are also consistent with the intrinsic line widths of forbidden atomic oxygen emission lines observed in comets. The photodissociation rates of H2O leading to O(1S) and O(1D) calculated here do not significantly change the previous estimates of CO2/H2O in comets based on the green-to-red line ratios of the comets if we use the photodissociation rates of CO2 (calculated elsewhere) with a correction for the difference of solar UV spectra used for calculating photodissociation rates of H2O and CO2.
Inflated Eccentric Migration of Evolving Gas Giants I – Accelerated Formation and Destruction of Hot and Warm Jupiters
Authors: Rozner Mor , Glanz Hila , Perets Hagai B. , Grishin Evgeni 
Published: May 2022

Abstract
Hot and warm Jupiters (HJs and WJs, correspondingly) are gas giants orbiting their host stars at very short orbital periods (P
HJ < 10 days; 10 < P
WJ < 200 days). HJs and a significant fraction of WJs are thought to have migrated from initially farther-out birth locations. While such migration processes have been extensively studied, the thermal evolution of gas giants and its coupling with migration processes are usually overlooked. In particular, gas giants end their core accretion phase with large radii, then contract slowly to their final radii. Moreover, intensive heating can slow the contraction at various evolutionary stages. The initial large inflated radii lead to faster tidal migration, due to the strong dependence of tides on the radius. Here, we explore this accelerated migration channel, which we term inflated eccentric migration, using a semi-analytical, self-consistent model of the thermal–dynamical evolution of the migrating gas giants, later validated by our numerical model (see the companion paper, paper II). We demonstrate our model for specific examples and carry out a population synthesis study. Our results provide a general picture of the properties of the formed HJs and WJs via inflated migration, and their dependence on the initial parameters/distributions. We show that the tidal migration of gas giants could occur much more rapidly then previously thought, and could lead to the accelerated destruction and formation of HJs and an enhanced formation rate for WJs. Accounting for the coupled thermal–dynamical evolution is therefore critical to understanding the formation of HJs/WJs, and the evolution and final properties of the population, and it plays a key role in their migration processes.
ALMA Survey of Orion Planck Galactic Cold Clumps (ALMASOP): Deriving Inclination Angle and Velocity of the Protostellar Jets from Their SiO Knots
Authors: Jhan Kai-Syun , Lee Chin-Fei , Johnstone Doug , Liu Tie , Liu Sheng-Yuan , Hirano Naomi , Tatematsu Ken’ichi , Dutta Somnath , Moraghan Anthony , Shang Hsien , Lee Jeong-Eun , Li Shanghuo , Liu Chun-Fan , Hsu Shih-Ying , Kwon Woojin , Sahu Dipen , Liu Xun-Chuan , Kim Kee-Tae , Luo Qiuyi , Qin Sheng-Li , Sanhueza Patricio , Bronfman Leonardo , Qizhou Zhang , Eden David , Traficante Alessio , Lee Chang Won ,   ALMASOP Team
Published: May 2022

Abstract
We have selected six sources (G209.55–19.68S2, G205.46–14.56S1-A, G203.21–11.20W2, G191.90–11.21S, G205.46–14.56S3, and G206.93–16.61W2) from the Atacama Large Millimeter/submillimeter Array Survey of Orion Planck Galactic Cold Clumps (ALMASOP), in which these sources have been mapped in the CO (J = 2−1), SiO (J = 5−4), and C18O (J = 2−1) lines. These sources have high-velocity SiO jets surrounded by low-velocity CO outflows. The SiO jets consist of a chain of knots. These knots have been thought to be produced by semiperiodic variations in jet velocity. Therefore, we adopt a shock-forming model, which uses such variations to estimate the inclination angle and velocity of the jets. We also derive the inclination angle of the CO outflows using the wide-angle wind-driven shell model and find it to be broadly consistent with that of the associated SiO jets. In addition, we apply this shock-forming model to another three protostellar sources with SiO jets in the literature—HH 211, HH 212, and L1448C(N)—and find that their inclination angle and jet velocity are consistent with those previously estimated from proper-motion and radial-velocity studies.
Radical Recombination during the Phase Transition of Interstellar CO Ice
Authors: He Jiao , Góbi Sándor , Ragupathy Gopi , Tarczay György , Henning Thomas 
Published: May 2022

Abstract
Complex organic molecules (COMs) can be produced efficiently in ice mixtures that simulate the ice mantle on cosmic dust grains, according to prior experimental studies. However, the mechanism that brings the reactive species together in the ice has been debated. Thermal diffusion, which is widely regarded as the main mechanism to bring reactants together, is inefficient at a typical dense cloud temperature of 10 K. A recent experimental study found that the transition of a thin CO ice film from the amorphous to crystalline phase happens at about 10 K. When a small fraction of CO2 was mixed with CO, the CO2 molecules can separate and form clusters during CO phase transition. It was further proposed that the separation of minor species in the CO ice during phase transition may be an important mechanism to form interstellar COMs without the need for thermal diffusion. In this study, we try to verify this new mechanism through laboratory experiments. An ice mixture of CH3OH and CO, which is an analog of the outer layer of the ice mantle on cosmic dust grains, was exposed to UV irradiation to produce radicals such as HCO and CH2OH, whose concentration was monitored during the subsequent warm-up of the ice. We find clear evidence that during the CO phase transition, most of the radicals recombine to form other molecular species, therefore supporting the recently proposed mechanism of COM formation via CO phase transition.