bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adsorption and Removal of Antibiotic Pollutants using CuO−Co3O4 Co‐modified Porous Boron Nitride Fibers in Aqueous Solution
Authors: Bai Wenjuan , Wang Bozheng , Yang Shaobo , Yan Song , Cao Chaochao , Zhou Zheng , Ji Jiawei , Guo Kai , Tang Chengchun 
Published: October 2022

AbstractThe presence of antibiotic contaminants in aqueous environment already poses significant risks to ecological sustainability, biodiversity and human public health and safety. Therefore, it is urgent to develop practical water pollution control technologies and new materials. Here, we prepared CuO−Co3O4 co‐modified porous boron nitride fibers (P−BNFs) for the adsorption and removal of tetracycline antibiotics (TCs) in aqueous environment. The prepared adsorbents were characterized by XRD, FTIR, XPS, SEM, TEM and BET, and the adsorption behavior was explored by batch experiments. The results show that the removal percentage for doxycycline (DC) reaches 98.68 %, which was much higher than that of P−BNFs, and the modification results of P−BNFs with CuO or Co3O4 alone. After five regeneration cycles, the removal rate of DC by CuO−Co3O4/P−BNFs was still as high as 89.33 %. This is promising and indicates that the prepared CuO−Co3O4/P−BNFs adsorbent has good renewable recycling performance and practical application prospects.
Impact of corporate governance on environmental, social, and governance disclosure: Any difference between financial and non‐financial companies?
Authors: Ellili Nejla Ould Daoud 
Published: October 2022

AbstractThis study investigates the potential impact of corporate governance on environmental, social, and governance (ESG) disclosure by differentiating between financial and non‐financial companies. Panel data regressions were applied to estimate these impacts using a sample of UAE‐listed firms during the period 2010–2019. In the estimations, different subsamples of financial and non‐financial companies were considered. The empirical results vary across financial and non‐financial companies but provide overall evidence of the positive impacts of institutional ownership, foreign ownership, board independence, and board diversity on ESG disclosure for both financial and non‐financial companies. Managerial ownership, blockholder ownership, and board size are negatively associated with non‐financial companies' ESG disclosure. This study is the first to provide a better understanding of the most effective UAE corporate governance mechanisms and the important role of ownership structure and board of directors in increasing ESG disclosure by differentiating between financial and non‐financial companies.
Design and implementation of ground power unit using a three‐level fault‐tolerant neutral point clamped inverter
Authors: Abbaspour Hasan , Madadi Kojabadi Hossein 
Published: October 2022

AbstractDue to the widespread use of static power converters in various industries and sensitive applications such as ground power units (GPUs), it is essential that the inverters have high reliability. A failure in the inverters can cause undesirable consequences such as low performance, shutting down the system, and losing the stability of the entire system. On the other hand, in some critical industrial processes with high standstill costs and safety‐aspect concerns, such as aircraft, high reliability, and survivability of the system, are very important. Therefore, the use of fault‐tolerant (FT) inverters is inevitable in such applications. In this paper, using a three‐level fault‐tolerant neutral point clamped (FT‐NPC) inverter, the reliability of the GPUs is increased and it results in higher availability and continuous system performance. Furthermore, a simple automatic fault detection (FD) algorithm is presented by taking the inverter pole voltage as a FD parameter. The inverter is analyzed for open‐circuit fault in the switches, and the reliability of the FT‐NPC inverter is compared with the classic inverter. The simulation and experimental results of the 2‐kVA converter prototype are presented to confirm the FT inverter performance and the proposed method.
Homologous peptides derived from influenza A, B and C viruses induce variable CD8+ T cell responses with cross‐reactive potential
Authors: Nguyen Andrea T , Lau Hiu Ming Peter , Sloane Hannah , Jayasinghe Dhilshan , Mifsud Nicole A , Chatzileontiadou Demetra SM , Grant Emma J , Szeto Christopher , Gras Stephanie 
Published: October 2022

AbstractObjectiveInfluenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally, infecting humans and causing widespread morbidity and mortality. Here, we investigate the T cell response towards an immunodominant IAV epitope, NP265‐273, and its IBV and ICV homologues, presented by HLA‐A*03:01 molecule expressed in ~ 4% of the global population (~ 300 million people).MethodsWe assessed the magnitude (tetramer staining) and quality of the CD8+ T cell response (intracellular cytokine staining) towards NP265‐IAV and described the T cell receptor (TCR) repertoire used to recognise this immunodominant epitope. We next assessed the immunogenicity of NP265‐IAV homologue peptides from IBV and ICV and the ability of CD8+ T cells to cross‐react towards these homologous peptides. Furthermore, we determined the structures of NP265‐IAV and NP323‐IBV peptides in complex with HLA‐A*03:01 by X‐ray crystallography.ResultsOur study provides a detailed characterisation of the CD8+ T cell response towards NP265‐IAV and its IBV and ICV homologues. The data revealed a diverse repertoire for NP265‐IAV that is associated with superior anti‐viral protection. Evidence of cross‐reactivity between the three different influenza virus strain‐derived epitopes was observed, indicating the discovery of a potential vaccination target that is broad enough to cover all three influenza strains.ConclusionWe show that while there is a potential to cross‐protect against distinct influenza virus lineages, the T cell response was stronger against the IAV peptide than IBV or ICV, which is an important consideration when choosing targets for future vaccine design.
Regulatory T cell‐derived interleukin‐15 promotes the diversity of immunological memory
Authors: Madi Alaa , Wu Jingxia , Ma Sicong , Weisshaar Nina , Mieg Alessa , Hering Marvin , Ming Yanan , Zettl Ferdinand , Mohr Kerstin , ten Bosch Nora , Schlimbach Tilo , Hertel Franziska , Cui Guoliang 
Published: October 2022

AbstractWhile the immunosuppressive function of regulatory T (Treg) cells has been extensively studied, their immune‐supportive roles have been less well investigated. Using a lymphocytic choriomeningitis virus (LCMV) Armstrong infection mouse model, we found that Treg cell‐derived interleukin (IL)‐15 is required for long‐term maintenance of the KLRG1+IL‐7Rα−CD62L− terminal effector memory CD8+ T (tTEM) cell subset, but dispensable for the suppressive function of Treg cells themselves. In contrast, deletion of Il15 from other sources, including myeloid cells and muscles, did not affect the composition of the memory CD8+ T cell pool. Our findings identify Treg cells as an essential IL‐15 source maintaining tTEM cells and suggest that Treg cells promote the diversity of immunological memory.
Microgrid to smart grid's evolution: Technical challenges, current solutions, and future scopes
Authors: Badal Faisal R. , Sarker Subrata K. , Nayem Zannatun , Moyeen Sumaya I. , Das Sajal K. 
Published: October 2022

AbstractRenewable energy (RE) sources play an important role that not only reduces the pressure on fossil fuels but also produces safe and clean energy by developing the microgrid (MG) technology that fulfills the excess demand for power throughout the world. The technological development and the blessing of information and communication technology converts the MG technology to a smarter one, termed as smart grid (SG) and virtual power plant, by establishing a two‐way communication between the consumers and service provider with the aid of smart metering infrastructure, dynamic pricing scheme, energy management system, smart transmission and distribution system. The transformation of the traditional power system to SG enhances the efficiency, flexibility, resiliency, and robustness of the power system due to the increasing level of cyber security and automation. A directional pathway from conventional to smart power system has been carried out in this paper by addressing the present status of the power system, challenges during the operations, and possible solutions. Initially, the control operation of MG with RE and energy storage system has been investigated which is essential to understand the operation complexity and challenges due to the variable nature of the RE, load dynamics, and uncertainties. But the facilities of end‐user feedback, dynamic pricing scheme, cyber security, and smart metering system are not present in MG technology that hampers the proper regulation of controlling operation, generating and distributing energy as well as energy losses. The development of SG with smart technologies overcomes these problems by proper controlling of power usage. Finally, this paper provides a path to move the MG toward SG by analyzing the technical and critical challenges of smart devices, equipment integration, and their control issues and provides possible solutions to overcome the integration and control challenges for a reliable and sustainable operation.
Impact of restrictive versus liberal transfusion and clinical outcomes in critically ill children: A retrospective observational study
Authors: Yuliarto Saptadi , Kadafi Kurniawan Taufiq , Azizah Luluk Nur , Susanto William Prayogo , Khalasha Takhta 
Published: October 2022

AbstractBackground and AimsCritically ill children with anemia often requires blood transfusion, which can cause several complications. It is important to decide when to start the red blood cell (RBC) transfusion; however, the guidelines is still lacking. The aim of this study was to compare restrictive and liberal transfusion strategy.MethodsThis is an observational retrospective study of critically‐ill children who receive RBC transfusion. Subjects categorized into two groups by initial hemoglobin (Hb), that is, restrictive (Hb ≤ 7 g/dl) and liberal (Hb ≤ 9.5 g/dl) strategy. In each group, subjects categorized based on: (1) Hb increment: high (increased ≥2.5 g/dl) and low (increase <2.5 g/dl) and (2) final Hb level: low (<7.0 mg/dl), moderate (7.0–10.0 mg/dl), and high (>10.0 mg/dl). Patient with hematologic or congenital disorder, severe malnutrition, chronic infection‐related anemia, and transfusion in Hb level ≥9.5 g/dl were exclude. Each patients were evaluated for the clinical outcome, which is: intensive care length of stay (IC‐LOS), length of mechanical ventilation (LoMV), and mortality rate.ResultsClinical outcome and mortality rates of both transfusion strategies are similar. The mortality rates were lower in higher Hb increment and final Hb level (p = 0.04 and p = 0.01, respectively). Multivariate analysis in all groups revealed mortality rate had moderate correlation with Hb increment (odds ratio [OR] = 0.694, 95% confidence interval [CI] 0.549–0.878; p = 0.002) and moderate correlation (OR = 0.642, 95% CI 0.519–0.795; p = 0.000) with final Hb level. The similar results was found after categorization based on transfusion strategy.ConclusionWe conclude the restrictive and liberal transfusion strategy have a similar effect to IC‐LOS, LoMV, and mortality rate. High Hb increment (≥2.5 g/dl) and moderate‐high final Hb (≥7.0 g/dl) after transfusion reduce the mortality rate.
Water cycling and partitioning through the soil–plant–atmosphere continuum in a subtropical, urban woodland inferred by water stable isotopes
Authors: Chen Ke , Liu Guodong , Xia Chengcheng , Meng Yuchuan , Tetzlaff Doerthe , Zhong Qiao , Chang Jianghao 
Published: October 2022

AbstractFor many urban woodlands, knowledge of how water is cycled and partitioned by plants is important for improving water management strategies, particularly during warm and wet periods with heavy, convective events in subtropical monsoon regions which are characterized by hot and humid summers. Still, most studies on these processes have been conducted in rural, none subtropical areas. Useful tools for tracing water movement during different precipitation events are stable water isotopes. So far, very few studies have been carried out in urbanized woodlands where the natural hydrological cycle is affected by strong anthropogenic influences. We conducted an intense spatio‐temporal sampling campaign of water isotopes, combined with relevant atmospheric parameters, climatic and hydrometric data across an evergreen broad‐leaved woodland near Chengdu, SW China, to assess event‐based changes in water cycling and partitioning during the warm and wet summer of 2020. Based on event‐scale precipitation samples, soil and plant water samples, we found similar temporal variations in the water isotopes of precipitation, soil, and plants, with a gradual enrichment in the order of precipitation – soil water – plant water. However, the responses of soil and plant water to precipitation were delayed. From the dynamics of soil water content and soil water isotopes, evaporative fractionation and precipitation signatures were determined as the critical factors in influencing water storage and compositions through the soil profile. Only precipitation events >5 mm recharged the soil profile, with a ~ 24 h time lag in the response time of soil water (0–50 cm) to effective events. The water isotopes in the branches and leaves of the plants reflected their water sources primarily from 0 to 50 cm soil layers and water losses through evapotranspiration, respectively. These isotopic signals described the transfer and exchange of water in the soil–plant‐atmosphere continuum and therefore improved our understanding of water cycling and partitioning in an urban woodland in a subtropical monsoon humid region, which may have important implications for urban green space and ecosystem services in other regions.
Brucein D imparts a growth inhibitory effect in multiple myeloma cells by abrogating the Akt‐driven signaling pathway
Authors: Jung Young Yun , Mohan Chakrabhavi Dhananjaya , Rangappa Shobith , Um Jae‐Young , Chinnathambi Arunachalam , Alharbi Sulaiman Ali , Rangappa Kanchugarakoppal S. , Ahn Kwang Seok 
Published: October 2022

AbstractThe Akt signaling pathway is an oncogenic cascade activated in the bone marrow microenvironment of multiple myeloma (MM) cells and contributes to their uncontrolled proliferation. Abrogation of Akt signaling has been presented as one of the prime therapeutic targets in the treatment of MM. In the present report, we have investigated the effect of Brucein D (BD) on Akt‐driven signaling events in MM cells. BD (300 nM) substantially inhibited cell viability and imparted growth‐inhibitory effects in U266 cells as evidenced by cell viability assays and flow cytometric analysis. Effect of BD on cell viability was evaluated by MTT assay. Apoptotic cells and cell cycle arrest by BD were analyzed by flow cytometer. The results of the TUNEL assay and western blotting showed that BD induces apoptosis of MM cells by activating caspase‐8 and 9 with subsequent reduction in the expression of antiapoptotic proteins (Bcl‐2, Bcl‐xl, survivin, cyclin D1, COX‐2, VEGF, MMP‐9). Analysis of activated kinases by Phospho‐Kinase Array Kit revealed that Akt, p70S6K, HSP60, p53, and WNK1 were strongly expressed in untreated cells and BD treatment reversed this effect. Using transfection experiments, AKT depletion led to a decrease in phosphorylation of Akt, mTOR, p70S6K, and WNK. However, Akt overexpression led to increase in phosphorylation of these proteins. Depletion of Akt potentiated the apoptosis‐inducing effect of BD whereas overexpression displayed resistance to BD‐induced apoptosis suggesting the role of Akt in chemoresistance. Taken together, BD mitigates Akt‐dependent signaling pathways in MM cells to impart its anticancer activity.
Development of fibroblast/endothelial cell‐seeded collagen scaffolds for in vitro prevascularization
Authors: Masson‐Meyers Daniela S. , Tabatabaei Fahimeh , Steinhaus Lane , Toth Jeffrey M. , Tayebi Lobat 
Published: October 2022

AbstractThe development of vascularized scaffolds remains one of the major challenges in tissue engineering, and co‐culturing with endothelial cells is known as one of the possible approaches for this purpose. In this approach, optimization of cell culture conditions, scaffolds, and fabrication techniques is needed to develop tissue equivalents that will enable in vitro formation of a capillary network. Prevascularized equivalents will be more physiologically comparable to the native tissues and potentially prevent insufficient vascularization after implantation. This study aimed to culture human umbilical vein endothelial cells (HUVECs), alone or in co‐culture with fibroblasts, on collagen scaffolds prepared by simple fabrication approaches for in vitro prevascularization. Different concentrations and ratios of HUVECs and fibroblasts seeded on collagen gel and sponge scaffolds under several culture conditions were examined. Cell viability, scaffolds morphology, and structure were analyzed. Collagen gel scaffolds showed good cell proliferation and viability, with higher proliferation rates for cells cultured in a 2:1 (fibroblasts: HUVECs) ratio and kept in endothelial cell growth medium. However, these matrices were unable to support endothelial cell sprouting. Collagen sponges were highly porous and showed good cell viability. However, they became fragile over time in culture, and they still lack signs of vascularization. Collagen scaffolds were a good platform for cell growth and viability. However, under the experimental conditions of this study, the HUVEC/fibroblast‐seeded scaffolds were not suitable platforms to generate in vitro prevascularized equivalents. Our findings will be a valuable starting point to optimize culture microenvironments and scaffolds during fabrication of prevascularized scaffolds.
More pain, more change? The mediating role of presenteeism and the moderating role of ostracism
Authors: Wang Yanxia , Ma Jie Yonas , Yuan Mengsha , Chen Chih‐Chieh 
Published: October 2022

AbstractPresenteeism has mainly been discussed in terms of its negative effects on both individuals and organizations. By conducting two studies, we posit that presenteeism is an active, problem‐focused coping strategy that health‐impaired employees use to endure difficult times, and that the process is attenuated by workplace ostracism. In Study 1, we adopt a resource‐based view of stress, identify the effects of two kinds of pain (i.e., physical pain and social pain) on presenteeism, and explore the positive implications of presenteeism by sampling 60 full‐time employees over 10 consecutive workdays. We find that episodic physical pain is positively related to presenteeism and ultimately drives job crafting at the daily level. Furthermore, workplace ostracism significantly weakens the daily relationship among episodic physical pain, presenteeism, and job crafting. Grounded in these findings, Study 2 is designed to explore the mechanisms through which ostracism moderates the relationship between physical pain and presenteeism. A two‐wave dataset from 187 employees reveals that ostracism reduces self‐esteem and then weakens the positive link between physical pain and presenteeism. In summary, we provide preliminary evidence that presenteeism may play a positive role in dealing with physical pain, and that social pain (i.e., ostracism) tends to weaken this positive role by reducing employee's self‐esteem.
Evaluation of the efficacy of modal analysis in predicting the pullout strength of fixation bone screws
Authors: Einafshar Mohammadjavad , Hashemi Ata , Kiapour Ali 
Published: October 2022

AbstractBackgroundPilot hole preparation has been shown to have an impact on the short and long‐term stability of the screw fixation constructs.PurposeInvestigation and comparison of two nondestructive modal analysis methods with conventional insertion torque (IT) and pullout tests in optimum pilot hole diameter detection.MethodsTwenty conical core titanium screws were embedded in high‐density polyethylene blocks with different pilot hole diameters. The maximum IT was recorded for each screw during implantation. Then, two modal analysis methods including accelerometer (classical modal analysis [CMA]) and acoustic modal analysis (AMA) were carried out to measure the natural frequency (NF) of the bone‐screw structure. Finally, stiffness (S), pullout force (Fult), displacement at Fult (dult) and energy dissipation (ED) were obtained from the destructive pullout test.ResultsThe IT increased, as the pilot hole diameter decreased. The maximum value of IT was observed in the smallest pilot hole diameter. The same trend was found for the Fult and the first NF derived from both modal methods except for 5.5 mm pilot hole diameter. The natural NFs derived from CMA and AMA showed high correlations in different groups (R2 = 0.94) and did not deviate from y = x hypothesis in linear regression analysis. The Fult, dult, and ED were measured 4800 ± 172 N, 3.10 ± 0.08 mm and 14.23 ± 1.10 N.mm, respectively.DiscussionNo significant change was observed in “S” between the groups. The highest Fult and first NF were obtained for the 5.5 mm pilot hole diameter. Both CMA and AMA were found to be reliable methods and can promote the undesirable contradiction between Fult and IT.
Effects of onion peel extract on bioactive components, textural and sensory characteristics of chickpea‐based fried snack
Authors: Siddiqui Nabia , Ali Tahira Mohsin , Butt Natasha Abbas , Abbas Tanveer , Hasnain Abid 
Published: October 2022

AbstractOnion peel waste is generated in huge amount during processing. This waste is a huge source of antioxidants specially quercetin. Therefore, it can be utilized to increase the phenolic and flavonoid content of food products. The present study proposed the use of different onion peel extracts (OPE) in a South Asian snack called “sew.” Sew is a cold‐extruded rod‐shaped snack made from chickpea flour and spices. After extrusion, it is deep fried till appearance of golden‐brown color. The polyphenols from onion peels were extracted in (a) EWE (ethanol and water‐based) medium, (b) EAAE (ethanol and acetic acid‐based) medium, and (c) WE (water extract). These three OPEs were separately sprayed over chickpea grits before making flours, which were then used for making sew. Antioxidant activity of EWE, EAAE, and WE extracts were found to be 59.06%, 36.85%, and 28.07%, respectively, and both gram‐positive and gram‐negative bacteria were inhibited by these three extracts. Addition of OPE led to a significant increase in antioxidant activity of snack (sew), and panelists were unable to perceive any statistical difference in control and extract added snacks in terms of sensory attributes. Interestingly, marked improvement was observed in textural characteristics (measured objectively) of snacks containing extracts and the percent decline in hardness as observed in EAAE, EWE, and WE containing fried snacks were found to be 56.83%, 37.95%, and 34.55%, respectively, after 60 day's storage, whereas 71.28% decline was recorded for control snack. Thus, incorporation of OPE proved to be an innovative method to improve the nutraceutical profile of chickpea‐based fried snack.