bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does exposure to green or blue space impact dietary intake and food choices among adults? A Systematic Literature Review.
Authors: Gilbourne Claire A. , Scarry Alan , Tierney Audrey C. , Connor Eibhlís M. O’ 
Published: November 2022

Abstract
The health benefits of exposure to greenspace are well researched; however, causal pathways for improved health outcomes are complex, and evidence is minimal on potential moderating factors. This review aimed to assess the strength of the evidence and potential impact of exposure to green and blue spaces on dietary outcomes in adults. The inclusion criteria for the review were based on the PICO criteria. Five databases were searched: CINAHL, GreenFILE, AMED, Medline, and PubMed, accessed on 14th June 2021. The Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Analytical Cross-Sectional Studies was used for quality assessment in all studies. Due to heterogeneity, narrative synthesis was conducted to evaluate the relationships between the included studies. Four observational studies which reported diet-related outcomes were included in the review, and participants within the studies ranged from 554 to > 350,000 participants. Other health outcomes, including physical activity and obesity, have also been reported. Socioeconomic status (SES) was identified as a significant determinant of dietary intake and food choice. Two studies found that dietary patterns were not correlated with exposure to greenspace. Due to the small number of articles retrieved and the paucity of evidence, the findings need to be interpreted with caution. Further research is required to elucidate the complex mechanisms involved. Research is also needed to determine which greenspace attributes impact dietary intake and food choices among adults. When developing public health interventions, the significant health benefits associated with different socioeconomic groups should be considered.
Exploratory cross-sectional study to evaluate the metalloproteinases role as ‘immunoscore’ for HPV-induced cervical lesions
Authors: Lopes Gisele Silva , Rocha Natália Pereira , Russomano Fabio Bastos , Avvad-Portari Elyzabeth , Andrade Cecília Vianna , Furtado Yara Lúcia , Guerra-Neto Nereu Gilberto Moraes , Roma Eric Henrique , Bonecini-Almeida Maria da Gloria , Fernandes Ana Teresa Gomes 
Published: November 2022

Abstract
Cervical cancer (CC) is the fourth most common type of cancer among women and is responsible for about 8% of female cancer deaths worldwide. Understanding how the tumor microenvironment behaves is essential to realize the carcinogenic process, and thus infer possible prognostic biomarkers in the CC development. One of the prognostic factors that has aroused interest in recent years is the increased expression of metalloproteinases (MMPs) in tumor tissues, which is associated with tumor growth and metastasis, and recurrence of degradation of extracellular matrix (ECM) components in tissues of different tumors. Thus, our objective is to evaluate the in situ distribution of MMPs+ cells (MMP-2, -7, -9), as well as TIMP-2+, EphA2+ and EfrinA1+ cells in intraepithelial (IE) and marginal stroma (MS) areas using the technique of immunohistochemistry and immunoscore analysis in low- and high-grade squamous intraepithelial lesions (LSIL and HSIL, respectively) and CC. We observed in MS, a high distribution of MMPs+ (-2, -7 and − 9), TIMP2+ and EPHA2+ cells in the HSIL and CC group compared to the control. Regarding IE, we observed this same pattern, except in EPHA2 where there was a decrease in the positive cells distribution in CC compared to control and LSIL. Regarding the “immunoscore”, from 15 possible profiles, we found statistical differences in only 9 (MMP-2+/MMP-9+, MMP-2+/EphA2+, MMP-7+/MMP-9+, MMP- 7+/TIMP-2+, MMP-7+/EphA2+, MMP-9+/EphA2+, TIMP-2+/EphA2+, TIMP-2+/EphrA1+ and EphA2+/EphrA1+) when the groups were compared. However, only the MMP-7+/MMP-9+ profile can be used as a prognostic factor for the development of CC and the MMP-7+/EphA2+, MMP-9+/EphA2+ and TIMP-2+/EphA2+ profiles may be related to the development of precancerous lesions. A more comprehensive review of longitudinal studies should be performed to link these “immunoscores” to CC progression and validate their value as a prognostic method.
Preparation, Characterization and Antiviral Evaluation of Curcumin-PLGA and Curcumin-metal oxide nanocomposite against SARS-CoV-2
Authors: Elbadawy Zahraa Ahmed , Mostafa Ahmed , Ragab Ghada M. , Shama Nora. M. Abo , El-Dek Samaa , El-Shahawy Ahmed A. G. 
Published: November 2022

Abstract
Our usual control strategies for viral infections are still not as effective as demand, and the need for different ways of treatment is still of high priority. Viruses undergo genetic mutations that prevent specific drugs from affecting new strains. This research is concerned with the usage of nanotechnology in the preparation of natural drug classes that can be more effective when dealing with emerging pathogens. Curcumin is a natural extract of Curcuma longa that is known for its wide therapeutically effect due to its binding with different enzymes and proteins in the body. The curcumin can bind to viral proteins and block their activity; however it has poor water solubility and bioavailability. Likely, curcumin nanoparticles have much better solubility and bioavailability. This can improve our traditional treatment or prophylactic methods for viral infections and pandemics. This study is concerned with curcumin nanoparticle formulations and their anti-viral activity. Curcumin has been loaded onto PLGA to form Cur-PLGA nanoparticles. In parallel, curcumin was added to ZnO to form a Cur-ZnO composite. The compositions of PLGA and ZnO preparations with different concentrations of curcumin were confirmed with a panel of physiochemical assays. In vitro, the Cur-ZnO composite demonstrated significantly higher anti-SARS-CoV-2 activity than Cur-PLGA with significantly higher host cell safety. The study emphasizes the preference of curcumin composite nanoparticles over curcumin loaded nanoparticles. This study highlights the robust antiviral activity of different curcumin-based ZnO nanoparticles. This preliminary study demands further preclinical and clinical studies to confirm the obtained results in vivo.
Oxidation of alcohols to carbonyl compounds over graphene oxide functionalized with copper-thiazole as a catalyst
Authors: Dehbanipour Zahra , Zarnegaryan Ali 
Published: November 2022

Abstract‎‒‎The catalytic behaviour of [Cu(II)Br2-BTP@MNPs] and [Cu(II)Br2-BTP@GO] catalysts have been studied for the oxidation of alcohol derivatives. The comparative study indicates that the [Cu(II)Br2-BTP@GO] possesses better catalytic activity over the [Cu(II)Br2-BTP@MNPs] catalyst. In this reaction, we used a green solvent such as water in presence oftert-Butyl hydroperoxide (tert-BuOOH) as oxidant. The prepared catalyst was characterized by AAS, XRD, FE-SEM, TEM, TGA, elemental analysis and FT-IR spectroscopic techniques, also FT-IR spectroscopy and X-ray diffraction (XRD) were used for characterization of recovered catalyst. The catalyst is stable and can be recovered even after five consecutive cycles of reaction with only a slight loss in its catalytic activity.
Cytotoxic, anti-proliferative, and apoptotic evaluation of Ramalina sinensis (Lichenized fungus, Ramalinaceae) on oral squamous cell carcinoma cell line; in-vitro study
Authors: Karimi Hanieh , Koopaie Maryam , Sohrabi Mohammad , Norouzi Hooman 
Published: November 2022

Abstract
Background: In response to the poor prognosis of oral squamous cell carcinoma (OSCC), the most frequent cancer in the oral cavity, efforts have been made to create more effective treatment methods based on natural products. Lichens are a source of active pharmacologic compounds, which have lately been discovered to be helpful in cancer treatment. Current research seeks to evaluate the impact of Ramalina sinensis (R. sinensis) lichen on the cell viability and apoptosis of OSCC cell lines, considering lichens’ anti-inflammatory and anticancer capabilities.
Methods: R. sinensis was selected for investigation of its effects on human oral squamous cell carcinoma cell line (KB cell line, NCBI Code: C152) and acetone and effect of methanol extract of R. sinensison OSCC cell line was investigated. The chemical composition and metabolic profiling of R. sinensis were investigated. Viability was assessed by MTT assay analysis, and apoptotic cells were measured using flow cytometry analysis. Scratch assay was used to assess cell migration.
Results: The chemical composition of R. sinensis was investigated using LC-ESI-MS/MS, and 33 unique compounds in acetone and methanol extract of R. sinensis were detected. The proliferation of KB cells was gradually but significantly inhibited by 6.25, 12.5, 25, 50, 100, and 200 μg/mL in a time-dependent manner. There was a statistically significant difference between acetone and methanol extract in the inhibition of cell proliferation. Flow cytometry results indicate an increase in apoptosis of OSCC cells by acetone extract. R. sinensis significantly inhibited the migration and invasion of OSCC cells in a concentration-dependent manner.
Conclusion: The results of the present study showed the positive effects of R. sinensis extract on the apoptosis of OSCC cells and the anticancer effects of R. sinensisextracts.
Association between weight change and 10-Year Atherosclerotic Cardiovascular Disease Risk among U.S. older adults: data from National Health and Nutrition Examination Survey (NHANES) 1999–2018
Authors: Peng yuxuan , Li Hongzheng , Lu Jieming , Liao Feifei , Yang Wenwen , Tan Ling , Lu Aimei , Wei Yue , Long Linzi , Qu Hua , Fu Changgeng 
Published: November 2022

AbstractBackgroundIt remains controversial regarding the association between weight change and cardiovascular disease risk in older adults (aged ≥60 years). This study aimed to evaluate the association between weight change and 10-year atherosclerotic cardiovascular disease (ASCVD) risk events in older adults.MethodsThis cohort study used data from the National Health and Nutrition Examination Survey (NHANES). Older adults aged 60-79 years who were free of self-reported ASCVD at the time of the NHANES interview were included. Data were collected from January 1999 to December 2018 and analyzed in March 2022. We focused on the associations between weight change and 10-year risk of ASCVD events with the percentage change in weight during short-term(1 year) and long-term (10 years), which categorized as moderate to high weight loss (≥10%), small weight loss (5.1-9.9%), stable weight (±5%), small weight gain (5.1-9.9%) and moderate to high weight gain (≥10%).ResultsThe number of participants was 2,322 (mean age 67.90 years; 41.65% female) for the long-term interval (10 years) in our analysis, and 2543 for the short-term interval (1 years). We only observed an inverse association between long-term weight loss and predicted 10-year ASCVD risk (loss≥10%: β=2.81, 95%CI=1.46, 4.16; loss 5.1%~9.9%: β=2.75, 95% CI=1.24, 4.26), but all intervals of weight gain ≥5% were not significant associated with higher risk than stable weight. However, in the subgroup analyses, the association between long-term weight loss and 10-year ASCVD risk was not significant in old-old (aged 75-79), obesity (BMI≥30 kg/m2), intentional weight loss, moderate physical activity, smokers, and diabetics.ConclusionsOlder adults (aged 60-79 years) with weight loss >5% over the past 10 years have excess predicted 10-year ASCVD risk. Our study supports the benefits of stable weight in promoting cardiovascular health in the elderly.
Using routine CT scans for the detection of osteoporosis and exploring factors that affect DXA results
Authors: Cao Chaozhi , Huang Xuanwu , Xiao Longyi , Deng Rui , Wen Huilong , Li Xiwen , Chen Yanjun , Li Yiqun 
Published: November 2022

Abstract
Background
Osteoporosis is prevalent among older adults but is an underdiagnosed condition. The purpose of this study was to explore the relationship between bone mineral density (BMD) and computed tomography (CT) attenuation based on dual-energy X-ray absorptiometry (DXA) as the reference standard and to predict the CT attenuation threshold for osteoporosis.
Methods
The cohort included 430 subjects (276 women and 154 men; mean age: 67.6 years) whose general information, CT attenuation, DXA, aortic calcification, and vertebral degeneration scores were collected. The relationship between DXA scores and aortic calcification and vertebral degeneration scores was analyzed by orderly logistic regression. The prediction of CT attenuation for osteoporosis was analyzed by receiver operating characteristic (ROC) curves.
Results
There was no significant difference in CT attenuation on the vertebral coronal, sagittal, or axial plane (p > 0.05). Obesity, paravertebral osteophytes, endplate sclerosis, and aortic calcification could impact the outcomes of DXA (p < 0.05). The sensitivity for distinguishing osteoporosis was at least 90% when the CT attenuation threshold was 120 HU; when the CT attenuation threshold was 81 HU, the specificity for distinguishing osteoporosis was at least 90%. When the threshold was 98 HU, the Youden index was the largest, with a specificity of 80.0% and a sensitivity of 82.3%.
Conclusions
CT attenuation of the lumbar spine can be used to identify patients with osteoporosis while reducing the influence of the bony structure around the vertebral body on the assessment of BMD.
Effect of Immersive Virtual Reality and Audiovisual Treatment for Gait Disorder in Parkinson's Disease (IVRTFPD study ) : A Prospective Randomised Controlled Clinical Trial
Authors: Ye Qinyong , Chen Lina , Cai Guoen , Jiang Rifeng , Wang Yingqing , Chen Zhiting , Zeng Yuqi , Chen Ying , Chen Xiaochun 
Published: November 2022

Abstract
OBJECTIVE
Immersive Virtual Reality Treatment for Parkinson's Disease (IVRTFPD study ) aims to compare the effect of immersive virtual reality training(VR) and audiovisual training (AV) for gait disorder in Parkinson's disease.
METHODS
Forty-four PD patients with gait disorder were enrolled and randomly divided into an immersive virtual reality (VR) group (n = 22), Audiovisual Treatment (AV) group (n = 22). The primary efficacy outcome measure was the change from baseline (Pre) to 6 weeks (Post 6w) and 14 weeks (Post 14w) visit in the Timed Up and Go test (TUGT). Magnetic resonance imaging (MRI) was assessed in baseline (Pre) and Post 14w visits.
RESULTS
The TUGT was reduced by 3.16s (95% CI, -4.18 to -2.13, P < 0.001) at 6 weeks and 2.36s (95% CI, -3.77 to -0.96, P < 0.001) at 14 weeks from baseline in VR group. The between-group difference (VR vs. AV) in the TUGT was − 2.64s (95% CI, -4.84 to -0.45; P = 0.019) at 6 weeks and − 2.44s (95% CI, -4.67 to -0.21; P = 0.013) at 14 weeks. The quantitative susceptibility mapping (QSM) value of the right internal Globus pallidus, right Pulvinar, and right Substantia nigra decreased, and the FA value of the left Superior Longitudinal Fasciculus, right Uncinate Fasciculus increased in the VR group compared with the Pre-test.
CONCLUSIONS
This study confirmed that the virtual reality and audiovisual training improved motor symptoms of PD patients, and the efficacy persisted even longer in the VR group. It may be related to improved iron metabolism and reduced iron deposition.
Hospital and post-discharge mortality in COVID-19 patients with a preexisting cancer diagnosis in Iran
Authors: Seyyedsalehi Monireh Sadat , Rahmati Marveh , Ghalehtaki Reza , Nahvijou Azin , Eslami Bita , Shaka Zoha , Allameh Seyed Farshad , Zendehdel Kazem 
Published: November 2022

Abstract

Background: Data on COVID-19 outcomes in cancer patients from low- and middle-income countries is limited. We conducted a large study about the mortality rate of COVID-19 in cancer patients in Iran.
Methods: We obtained clinical characteristics and outcomes of COVID-19 in cancer and non-cancer patients. Based on logistic regression models, the odds ratios (ORs) and 95% confidence intervals (CIs) for hospital death and 60-day mortality of cancer patients were estimated.
Results: The cancer patients had higher ICU admission (35.8% vs. 26.6%) and intubation (25.4 vs. 11.6%) than non-cancer patients. Hospital mortality was higher in cancer patients (37.2%) than in non-cancer patients (15.2%) (OR = 4.56, 95% CI 3.51-5.93). Among cancer patients, mortality rates of the lung (OR = 1.57) and colorectal (OR = 1.50) cancers were higher than other cancer patients, albeit these associations were not statistically significant. The risk of 60-day mortality was significantly higher in lung cancer (OR = 1.75, 95% CI 1.04-2.93). The risk of COVID-19 death was higher in cancer patients who had an oxygen saturation less than 85% (OR = 1.79, 95% CI 1.20 -2.69), were on active treatment (OR = 1.94, 95% CI 1.43-2.6), or had metastasis (OR = 3.32, 95% 2.30-4.79) during the COVID-19 infection.
Conclusion: COVID-19 mortality was higher in cancer patients, especially with active disease and metastatic. Among others, lung cancer patients experience the worst prognosis from COVID-19 infection. The excess risk of death after discharge from the hospital suggests providing follow-up care for cancer patients after discharge from a COVID-19 hospitalization.
Is the absolute lymphocyte count a biomarker for neonates with necrotizing enterocolitis needs surgical consultation?
Authors: Zhong# Weitao , Chen# Jiale , He Qiuming , He Juan , Zou Pengjian , Tian Yan , Ma Zuyi , Zhong Wei 
Published: November 2022

Abstract
Background: Previous studies reported contradicting results about the association between the absolute lymphocyte count and necrotizing enterocolitis. The aim of this study was to explore whether the absolute lymphocyte count of (ALC) can be a biomarker for neonates with necrotizing enterocolitis needs surgical consultation.
Methods: We retrospectively analyzed perinatal data, clinical features before NEC onset (T0), laboratory values at T0 and at the time within the 24h after NEC onset(T1) from neonates with confirmed NEC who were admitted to Guangzhou Women and Children’s Medical Center from January 2016 to June 2021. Univariate and multivariate logistic regression analyses were used to evaluate predictive factors of surgical NEC. Receiver operating characteristics analysis was used to evaluate cutoffs and predictive values.
Results: Overall, 224 neonates with NEC were identified, including 80 cases (35.7%) underwent surgical intervention (surgical NEC) and 144 cases (64.3%) were managed with conservative treatment (medical NEC). Multivariate Logistic regression analysis showed that male gender [p value, adjusted odds ratio [95%CI]; 0.002, 3.36(1.53-7.35)], low ALC on T1[(<0.001, 0.37(0.25-0.55)] were identified as independent risk factors for surgical NEC. The area under curve (AUC) of ALC on T1 was 0.814 (95% CI 0.757~0.871). The optimal cut-off value was 2.10*109/L with 80% sensitivity and 74% specificity.
Conclusion: In neonates with NEC, low ALC may indicate a higher probability of needing surgical intervention. Timey surgical consultation may assist in the early diagnosis of the surgical NEC and avoid missing the optimal timing of surgery.
Geometrically nonlinear vibration of The Vierendeel Sandwich Plate
Authors: Dingyuan Liu , Kejian Ma , Yaqin Lu , Kaicong Kuang 
Published: November 2022

Abstract
The fourth-order geometrically nonlinear partial differential equations of motion for the Vierendeel Sandwich Plate with five generalized displacements are established considering the second-order nonlinear variables in the displacement components of the Green strain tensor. The plate is composed of an upper surface plate, inferior rib, superior rib, and short column. Considering the isotropy of the upper surface plate and the equivalent plate material of the inferior rib and superior rib, the transverse shear stress is not considered. The short column is equivalent to a transversely isotropic sandwich layer of material, and only its transverse shear stress is considered. The geometric nonlinear vibration equations of the Vierendeel Sandwich Plate are obtained by functional variation. Then, the geometric nonlinear vibration solution expressed by the elliptic function is obtained by using Galerkin's method, and the curves of the relationship between the ratio of the linear period to the nonlinear period and the amplitude under different side length ratios are obtained. The numerical simulation results of nonlinear equations show that with the superposition of modes, there are periodic, multi-periodic, and chaotic responses, indicating that these motions occur alternately. The developed theory is an extension of the plate vibration theory.
Heterogeneously catalyzed palm biodiesel production in intensified fruit blender
Authors: Wongjaikham Wijittra , Kamjam Manita , Wongsawaeng Doonyapong , Ngaosuwan Kanokwan , Kiatkittipong Worapon , Hosemann Peter , Assabumrungrat Suttichai 
Published: November 2022

Abstract

This research investigated palm biodiesel production via solid base-catalyzed transesterification in an intensified kitchen fruit blender. Studied parameters included methanol to palm oil molar ratio, CaO catalyst loading, reaction temperature and reaction volume. Characteristics of CaO catalyst were investigated by X-ray diffraction (XRD) and Fourier-transform infrared (FT-IR) spectroscopy techniques. An optimal condition was achieved with 15:1 of methanol to palm oil molar ratio, 5 wt.% of CaO dosage, 60oC of reaction temperature and 1,000 mL of reaction volume, obtaining the highest FAME production of 97.58% and yield efficiency of 1.56×10-3 g/J. Crystal structure of catalyst showed structural change after calcination while FT-IR illustrated alteration of various functional groups through reusability experiment demonstrating exceptional activity stability. Properties of biodiesel produced conformed to international standards. Use of CaO catalyst in biodiesel production provides positive effect on reuse, reduces wastewater from washing process, lowers production cost and is environmentally responsible.
Investigation of Sleep and Awake Bruxism Habit Experienced by People Who Quarantined Different Places During the COVID-19 Pandemic Running title: Investigation of Sleep and Awake Bruxism During the COVID-19 Pandemic
Authors: Genc Gizem B Celebioglu , Orhan Kaan 
Published: November 2022

Abstract
Introduction:
This study aimed to investigate sleep and awake bruxism habit experienced by people who quarantined different places during the COVID-19 pandemic in the TRNC.
Material and Methods
A 25-question self-reported questionnaire was sent to the patients' mobile phones to measure their demographic information, the level of bruxism habits which they experienced before and during their quarantine period while sleeping and awake, and asked to answer. The answers were evaluated statistically by percentage and chi-square test.
Results
241 people participated in our research. During the quarantine period, there was an increase in awake bruxism and a slight decrease in sleep bruxism. While the feelings worried, scared, panic and hopelessness felt by the participants in the first days of the quarantine decreased in the last days of the quarantine but calm was increased regardless of the place and length of stay in the quarantine. Teeth clenching, teeth grinding and earache were mostly seen in those who stayed in dormitory quarantine.
Conclusion
People's anxiety is increasing in the COVID-19 pandemic and there is a positive correlation between anxiety and both sleep and awake bruxism. Dentists should pay more attention to the signs of bruxism during the examination, especially from people who say that they are in quarantine during the anamnesis. Although the reason for the patient's visit to the doctor may seem like just a simple toothache, the underlying factors such as clenching should not be forgotten with a holistic approach and awareness should be created for the patient.