bluuebunny/crossref_metadata_2025_split huggingface dataset:
A dynamic Bayesian ARMA model for hydrological drought forecasting
Authors: Li Min , Zhang Mingfeng , Zhu Liming , Peng Zhuoyue , Cao Runxiang 
Published: April 2022

Abstract
A time series analysis is proposed for an adaptive design framework in nonstationary conditions. In this study, a dynamic Bayesian autoregressive moving average model (t-ARMA) is developed for modelling a standardized runoff index (SRI) time series. The t-ARMA model takes into account the possible change points in the SRI series, and the structure of the model changes with time. Bayesian theory is carried out to estimate the t-ARMA model parameters and locations of change points using a strategy of Markov chain Monte Carlo (MCMC) methods. The results demonstrate that using the Bayesian method to estimate the parameters of the ARMA and t-ARMA models could capture the SRI series characteristics, and the performances of the t-ARMA model are compared with those of the traditional autoregressive moving average (ARMA) model, showing that the t-ARMA model capable of taking the change point of the time series into account is more robust than the traditional ARMA model.
Simultaneous Determination of Paracetamol and Orphenadrine Citrate in Rat Plasma using LC–MS/MS Spectrometry Method: Pharmacokinetics and Drug-Drug Interaction Profile Studies
Authors: Sebaiy Mahmoud M. , El-Adl Sobhy M. , Mattar Amr A. , Elgawish Mohamed Saleh 
Published: April 2022

Abstract
Herein, it is the first developed and fully validated LC-MS/MS method for simultaneous determination of paracetamol (PAR) and orphenadrine citrate (ORP) in rat plasma after oral administration in respect of therapeutic drug monitoring, bioequivalence, pharmacokinetic (PK) and drug-drug interaction (DDI) studies. PAR and ORP were extracted from plasma sample using ACN-induced protein precipitation method. The separation procedure was carried out on an Agilent Eclipse Plus ODS (4.60 x 100 mm, 3.50 μm) column using water-enriched gradient mobile phase consisting of 6 mM ammonium formate plus 0.1% formic acid and ACN at a flow rate of 0.5 mL min-1. The mass spectrometry parameters were optimized and multiple reaction monitoring (MRM) in positive ion mode of two transitions was utilized for quantification of precursor to production at m/z 152 → 110 & 65 for PAR as [M+2H]2+, 270.3 → 181 for ORP as [M + H] +. According to US-FDA bioanalytical requirements, the proposed method was verified in terms of linearity, selectivity, recovery, accuracy, precision, matrix effects, and stability. The method was linear in the range of 1-5000 and 1-500 ng mL-1 with detection limits (S/N of 3) of 0.12 and 0.07 ng mL-1 for PAR and ORP, respectively. The selectivity and high sensitivity of the method succeeded in the study of PK parameters and DDI between PAR and ORP after oral dose administration. The synergistic action between the two drugs was confirmed by studying variable parameters like Ka, Tmax, Cmax, AUC0-24, MRT, and Cl/F. PAR affects the absorption of ORP and decreases its Cmax but increases its Tmax in accordance with elevating AUC0–24 and reducing Cl/F for both drugs. The current PK research is a useful tool for determining the DDI of both medicines and might be used in therapeutic drug monitoring and bioequivalence studies.
Effects of simulated nitrogen deposition on the ecophysiological responses of Populus beijingensis and P . cathayana under intra- and interspecific competition
Authors: Chen Lianghua , Mi Jiaxuan , Hao Linting , He Fang , Yang Hanbo , Wan Xueqin , Zhang Fan , Lin TianTian 
Published: April 2022

Abstract
Aims N deposition has become a major driver of a decline in species richness and biodiversity loss. We aim to discover whether N deposition could affect competitive relationships between poplars to predict threats posed by the introduction of exotic hybrids to native relative species.Methods Intra- and interspecific competition was investigated for an introduced hybrid poplar (Populus beijingensis) and the native paternal species P. cathayana under two N deposition regimes (with and without N deposition). Results Under control conditions, P. cathayana grown under either of the competition modes showed consistently greater above-ground biomass, root-to-shoot ratio (R/S), photosynthetic capacity, higher activities of N-assimilation enzymes in leaves, and preference for N-NO3- than corresponding P. beijingensis. Interspecific competition increased the leaf area (LA), specific leaf area (SLA), R/S, and photosynthetic nitrogen use efficiency (PNUE) in P. cathayana, but decreased PNUE in P. beijingensis compared to the values under monoculture. Thus, P. cathayana can gain a competitive advantage over P. beijingensis at low N availability. In contrast, under N deposition, P. beijingensis grown in a mixture showed more positive responses in growth, higher plasticity in biomass allocation, more flexible fine root traits, and the shift for N-NO3- preference when compared with P. cathayana, which resulted in relatively higher values in LA, SLA, and biomass accumulation in P. beijingensis. Conclusions Our results suggest that N deposition could reverse competitive relationships between the poplars, and exotic P. beijingensis has the potential to outcompete and displace native P. cathayana under growing N deposition.
Fabrication of silver monoliths using Brij 52 as surfactant and their applications to reduce fast sulphon black F dye and sensor against Pb
Authors: Khan Farid , Dangi Sambhavna Singh , Shrivastava Kavya , Bano Mustri , Nema Ankita , Rai Mansi 
Published: April 2022

Abstract
Silver monoliths were prepared using Brij52 as surfactants with and without dextran and reinforcing agents TiO2NPs by modified sol-gel technique. The as synthesized monoliths were characterized by fourier transformed infrared spectroscopy (FT-IR), power X-ray diffraction analysis, scanning electron microscopy (SEM), transmission electron microscopy, brunauer –emmett – teller (BET) adsorption analysis, thermogravimetric analysis (TGA), and gas chromatographic mass spectrometry. Ag/Brij-52/Dex/TiO2 monolith reduced fast sulphon black F dye in 1.5 min in presence of NaBH4. As synthesized silver monoliths were also used as sensors against toxic Pb in KNO3 at pH 5 with retention of limit of detection (LOD) 0.623 ngmL− 1 and limit of quantization (LOQ) 0.265 ngmL− 1.
Effects of Early Pelvic Floor Muscle Training on Early Recovery of Urinary Incontinence After Prostate Surgery
Authors: Chen Yi-Hsuan , Juan Yung-Shun , Wei Wei-Chi , Chueh Kuang-Shun , Lee Hsiang-Ying 
Published: April 2022

Abstract
Background:Post-prostate surgeries urinary incontinence (UI) is one of the common bothersome complications of prostate surgery. Pelvic floor muscle exercises (PFME) have been reported to have benefits in shortening postoperative recovery time of urinary incontinence. The aim of our study is to evaluate the efficacy of intensive schedule of Pelvic floor muscle exercises and pelvic muscle electrical stimulation(ES) in improving the recovery of postoperative urinary incontinence.Methods:We prospectively enrolled 72 patients (63 Benign prostate hyperplasia(BPH) and 9 Prostate cancer(PC)) who received transurethral resection of prostate(TURP), anatomical endoscopic enucleation of prostate(AEEP), Radical prostatectomy(RP) from January 2019 to December 2020. 27 patients who are unable to remove Foley catheter before discharge, or loss follow-up were excluded. Finally, we enrolled 44 patients (35 Benign prostate hyperplasia and 9 Prostate cancer). All patients were assessed using the pad test, International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS). Abdominal ultrasonography or Transrectal Ultrasound of Prostate (TRUS-P) was used to measure prostate volume and the postvoid residual urine volume (PVR). Results:The rate of UI was 60% and 88.9% immediately after removing Foley catheter in TURP/AEEP and Radical prostatectomy group respectively. The incontinence rates in TURP/AEEP were 34.2%, 20%, 3% after 2 weeks, 1 month and 3 months post-operation. In the Radical prostatectomy group, the incontinence rate was 55.6%, 44.4% after 2 weeks, and 1 month post-operation. The pad amount was 63.11±52.9g, 37.89±52.99g and 13.22±18.48g after 2 weeks, 1 month and 3 months post-operation.Conclusion:We demonstrated early intensive PFME program can shorten recovery time of UI after prostate surgery.Trial registration:This study was approved by our institutional review board [KMUHIRB-F(I)-20190092]
Changes in Projectile design and size of prey reveals the role of Fishtail points in megafauna hunting in South America
Authors: Prates Luciano , Rivero Diego , Perez S. Ivan 
Published: April 2022

Abstract
Fishtail are the earliest widespread projectile point in South America and share chronology and techno-morphological features with Clovis, the oldest north American projectile type; both were temporally associated with the late Pleistocene megafaunal extinctions. Although the elusive direct evidence of human exploitation of megafauna in South America had kept Fishtail out of the extinction’s debate, a recent paper proposed that successful dispersal of Fishtail points from 12.9 k years BP contributed to the extinctions. If so, and if humans came into South America around 15.5 k years BP but only affected megafauna 2.5 k years later, after the emergence of Fishtail points, this technology must be distinctly different from other early point types in terms of distribution and functional properties. In this paper evaluate the relationship between changes in projectile point technology and body mass of potential megafaunal prey and show that Fishtail were strongly linked to the largest extinct megafaunal species.
Analytical Study on Response Spectrum Analysis of Different Earthquake Resistant Models Using ETABS
Authors: Y. BalaBalaji , G. Yesuratnam 
Published: April 2022

Abstract
The earthquake's rapid and unexpected nature exacerbates its psychological impact, shaking people's morale. The destruction caused by earthquakes will be most effectively mitigated if structures are designed to be earthquake-resistant in the first place. The current study compares four distinct seismic resistant models with dimensions of 35 m*5 m*45.7 m (G + 9) taking Zone IV (Delhi), Response Spectrum Analysis according to clause 7.7 & 7.7.5 of IS 1893 (part 1): 2016 and stiffness modifiers from Table 6 of IS 16700: 2017 with Model 1 using ETABS. Model 2 has shear walls on the four outer edges. Model 3 is isolated with a lead rubber bearing (LRB) by considering a separate design for LRB from the base reactions of the fixed base model (Model 1), and Model 4 is isolated with a friction pendulum isolator bearing (FPB), with the design of FPB also included. Model 5 includes fluid viscous dampers on all four corner faces. When compared to Model 1 (2.227 sec), the time period increased by 52.45% (3.395 sec), 25.73% (2.8 sec), and decreased by 21.87% (1.74 sec), 50.47% (1.103 sec) in Models 3,4,5, and 2, respectively, suggesting that Model 3 is more flexible, causing the structure to be seismic resistant. Comparison graphs for base shear, storey stiffness, modal time-period, storey drift, and storey displacement are proposed.
Nutritional status and dietary habits of elderly population and their association with socio-demographic factors in a village of Punjab.
Authors: Babar Sharjeel , Arif Tanzeela , Shakoor Abdul , Ashraf Tabinda , Anwaar Tooba 
Published: April 2022

Abstract
Objectives:
To assess the nutritional status and dietary habits of elderly population and their associations with socio-demographic factors in a rural area.
Design:
This is an analytical cross sectional study.
Setting:
This study was conducted in a village named Jia Bagga, district Lahore, Pakistan.
Participants:
Data was collected from a sample of 100 elderly subjects (age 60 or above).
Results:
The mean age of the subjects was 69.08 and mean BMI was 25.09. Out of 100 individuals that participated 22% were malnourished and 50% were at risk of malnourishment. Malnourishment was found to be significantly associated with age, financial dependency, physical activity, overall eating habits. 18% of the subjects had fair, 81% had good and only 1% had excellent eating habits.
Conclusion:
The findings revealed that the nutritional status of elderly is not satisfactory, majority of elderly were either at risk or were malnourished. Therefore, interventions to improve nutritional status in low income older age individuals who mostly depend on others for their nutritional needs in rural segments are needed.
Environmental Practices and Care of the Territory: Use of Plants in Istmina and Condoto, Chocó.
Authors: Raad Alieth Ariana , Palacios Leider Palacios , Valencia Javier Gonzaga 
Published: April 2022

Abstract
The study of biocultural relations helps us understand how human societies have appropriated their territory, generating an interdependence that, through history and the current environmental crisis through which contemporary societies are passing, shows the imbalance in conceiving the relationship between nature and culture. This connection is essential for those who seek to generate strategies guaranteeing the sustainability of conservation processes in the territory. The study site was Basurú and Acosó, rural Istmina and Condoto, respectively. The overall objective of the research was to contribute to the identification and recognition of community biocultural knowledge as a strategy of permanence and self-management of their territories. This participatory research included: 1) identifying the main plant species used by the communities for daily activities, 2) characterization of their main uses and properties (medicinal, food, forestry, magic-religious, others), states of threat, associated activity, and modes of use. A qualitative methodology was used, including applying ethnographic techniques: open and semi-structured interviews, questionnaires in search of data on uses, properties, and associated activity, participant observation, guided excursions, and review of secondary information. It was determined that some of the daily use species had been introduced. Others are native, all classified according to their uses: medicinal, forest, food, magic-religious, and others. As a result, there is a direct association between the medicinal and food species, to a lesser extent the medicinal species with the magical-religious and finally the forest species. Most medicinal ones are used to treat respiratory affections, tropical diseases, deworming, midwifery, traumas and womb diseases.
Evaluating clinician experience in value-based health care: The development and validation of the Clinician Experience Measure (CEM)
Authors: Harrison Reema , Manias Elizabeth , Ellis Louise , Walpola Ramesh , Roxas-Harris Ben , Mitchell Rebecca , Dobbins Timothy , Lvl Catherine Chan , Cowie Sharyn , Maberly Glen , Mimmo Laurel , Hay Liz 
Published: April 2022

Abstract
Background
Clinicians’ experiences of providing care constitute an important outcome for evaluating care from a value-based healthcare perspective. Yet no currently available instruments have been designed and validated for assessing clinicians’ experiences. This research sought to address this important gap by developing and validating a novel instrument in a public health system in Australia.
Methods
A multi-method project was conducted using co-design with 12 clinician leaders from a range of NSW Health Local Health Districts to develop the Clinician Experience Measure (CEM). Validity and reliability analyses were conducted in two stages, first assessing face and content validity with a pool of 25 clinicians and then using psychometric analysis with data from 433 clinicians, including nurses, doctors and allied health and representing all districts within one jurisdiction in Australia.
Results
Data gathered from 25 clinicians via the face and content validity process indicated that the initial 31-items were relevant to the range of staff employed in the NSW state health system, with minor edits made to the survey layout and wording within two items. Psychometric analysis led to a rationalised 18-item final instrument, comprising four domains: psychological safety (4-items); quality of care (5-items); clinician engagement (4-items) and interprofessional working (5-items). The 18-item four-factor model produced a good fit to the data and high levels of reliability, with factor loadings ranging from .62 to .94, with Cronbach’s alpha (range: .83 to .96) and composite reliability (range: .85 to .97).
Conclusions
The CEM is an instrument to capture clinicians’ experiences of providing care across a health system. The CEM provides a useful tool for healthcare leaders and policy makers to benchmark and assess the impact of value-based care initiatives and direct change efforts.
A retrospective study of preoperative malnutrition based on the Controlling Nutritional Status score as a predictive marker for short-term outcomes after open and minimally invasive esophagectomy for esophageal cancer
Authors: Horinouchi Tomo , Yoshida Naoya , Harada Kazuto , Eto Kojiro , Sawayama Hiroshi , Iwatsuki Masaaki , Iwagami Shiro , Baba Yoshifumi , Miyamoto Yuji , Baba Hideo 
Published: April 2022

Abstract
PurposePreoperative malnutrition is a significant risk factor for post-esophagectomy morbidity. The Controlling Nutritional Status (CONUT) is an index used to assess the nutritional status, and it has been suggested to predict post-esophagectomy morbidity. However, the difference in the predictive value of CONUT in estimating morbidities between open esophagectomy (OE) and minimally invasive esophagectomy (MIE) has not yet been elucidated.MethodsThis study included 674 patients(OE, 295; MIE, 378) who underwent three-incision esophagectomy for esophageal cancer between April 2005 and August 2021. The patients were further divided into two groups according to their preoperative CONUT: normal and light malnutrition and moderate and severe malnutrition. Short-term outcomes between these groups were retrospectively compared in the OE and MIE groups.ResultsModerate and severe malnutrition was significantly associated with a low body mass index, a poor performance status and American Society of Anesthesiologists physical status, advanced cancer stage, and frequent preoperative treatment. These patients also experienced significantly more frequent severe (p=0.016), respiratory (p=0.0013) and cardiovascular morbidities (p=0.013) after OE. Moreover, malnutrition in CONUT was an independent risk factor for severe (hazard ratio [HR]=3.38; 95%confidence interval [CI], 1.225-9.332; p=0.019), respiratory (HR=3.00; 95%CI, 1.161-7.736; p=0.023), and cardiovascular morbidities (HR=3.66; 95%CI, 1.068-12.55; p=0.039) after OE. However, it was not associated with the incidence of morbidities after MIE.ConclusionPreoperative malnutrition in CONUT reflects various disadvantageous clinical factors and could be a predictor of worse short-term outcomes after OE. Meanwhile, the low invasiveness of MIE might reduce the effect of preoperative malnutrition on worse short-term outcomes.
Relationship between daily swallowing frequency and pneumonia in patients with severe cerebral palsy: a retrospective study
Authors: Tanaka Nobukazu , Nohara Kanji , Uota Chisato , Fujii Nami , Obana Aya , Tanaka Katsuji , Sakai Takayoshi 
Published: April 2022

Abstract
Background: Patients with cerebral palsy are known to have reduced swallowing function because of various causes. Aspiration pneumonia resulting from decreased swallowing function is a major complication in patients with severe cerebral palsy and is directly associated with their survival prognosis. This necessitates an appropriate assessment and response to the aforementioned risk. Previous reports on cerebral palsy patients have mentioned large differences in the prevalence of aspiration, when assessed with standard swallowing function tests. Moreover, there is a weak association between aspiration detected by swallowing function tests, such as video endoscopy and video fluoroscopy, and the incidence of pneumonia. Considering the difficulty in evaluating the risk of pneumonia, we focused on swallowing frequency as an index of daily swallowing function. Swallowing motion protects the airway by safely directing the food, saliva, and secretions accumulated in the pharynx into the esophagus to prevent aspiration and entry into the trachea. Thus, swallowing frequency during daily life can be considered an index for evaluating the risk of regular aspiration and pneumonia. In this retrospective study, we investigated the relationship between swallowing frequency and pneumonia in patients with severe cerebral palsy. Methods: Fifty seven cerebral palsy patients were included in this study. The swallowing frequency was measured three times for each patient on separate days, and the reproducibility was examined by calculating the intraclass correlation coefficient. Further, the relationship between swallowing frequency and history of pneumonia was investigated by multivariate logistic regression analysis.Results: While the swallowing frequency differed between participants, it was constant within individuals (intraclass correlation coefficient: 0.941). Furthermore, the swallowing frequencies per hour were 12.2 ± 12.2 and 27.0 ± 20.4 in the patient groups with and without a history of pneumonia, respectively (P<0.001). Swallowing frequency (odds ratio: 10.489, 95% confidence interval: 2.706–40.663, P=0.001) was significantly associated with the incidence of pneumonia in the previous year.Conclusions: Swallowing frequency could be used as an index for assessing the risk of dysphagia and pneumonia in patients with severe cerebral palsy.
A case report of a dramatic response to Afatinib in a patient with advanced adenosquamous carcinoma lung cancer (ASC) harboring EGFR L861R
Authors: Zhao Tingting , Gui Xianhua , Shi Shenyun , Lu Zhongyu , Lu Guanghua , Deng Wanglong , Ding Ran , Bu Fanfeng , Ding Jingjing 
Published: April 2022

Abstract
Lung cancer is a malignant tumor with high incidence and mortality in China. Furthermore, non-small cell lung cancer(NSCLC) accounts for more than 85%. About 30-40% of Asian populations carry epidermal growth factor receptor (EGFR) gene mutations. EGFR mutations mainly occur in exon 18-21, and the common mutations are exon 19 deletions (19del), L858R, which are all sensitive to EGFR tyrosine kinase inhibitors(EGFR-TKIs). Nevertheless, the efficiency of the EGFR-TKIs on EGFR L861R remains unknown. In this article, we report a patient with adenosquamous carcinoma lung cancer(ASC) harboring EGFR L861R who was treated with afatinib and obtained progression-free survival(PFS) for more than 24 weeks.