bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast algorithm and new potential formula represented by Chebyshev polynomials for an $$m\times n$$ globe network
Authors: Zhou Yufan , Zheng Yanpeng , Jiang Xiaoyu , Jiang Zhaolin 
Published: December 2022

AbstractResistor network is widely used. Many potential formulae of resistor networks have been solved accurately, but the scale of data is limited by manual calculation, and numerical simulation has become the trend of large-scale operation. This paper improves the general solution of potential formula for an $$m\times n$$

m
×
n

globe network. Chebyshev polynomials are introduced to represent new potential formula of a globe network. Compared with the original potential formula, it saves time to calculate the potential. In addition, an algorithm for computing potential by the famous second type of discrete cosine transform (DCT-II) is also proposed. It is the first time to be used for machine calculation. Moreover, it greatly increases the efficiency of computing potential. In the application of this new potential formula, the equivalent resistance formulae in special cases are given and displayed by three-dimensional dynamic view. The new potential formulae and the proposed fast algorithm realize large-scale operation for resistor networks.
Nrf2 and Parkin-Hsc70 regulate the expression and protein stability of p62/SQSTM1 under hypoxia
Authors: Siswanto Ferbian Milas , Mitsuoka Yumi , Nakamura Misato , Oguro Ami , Imaoka Susumu 
Published: December 2022

AbstractSolid tumors often contain regions with very low oxygen concentrations or hypoxia resulting from altered metabolism, uncontrolled proliferation, and abnormal tumor blood vessels. Hypoxia leads to resistance to both radio- and chemotherapy and a predisposition to tumor metastases. Under hypoxia, sequestosome 1 (SQSTM1/p62), a multifunctional stress-inducible protein involved in various cellular processes, such as autophagy, is down-regulated. The hypoxic depletion of p62 is mediated by autophagic degradation. We herein demonstrated that hypoxia down-regulated p62 in the hepatoma cell line Hep3B at the transcriptional and post-translational levels. At the transcriptional level, hypoxia down-regulated p62 mRNA by inhibiting nuclear factor erythroid 2-related factor 2 (Nrf2). The overexpression of Nrf2 and knockdown of Siah2, a negative regulator of Nrf2 under hypoxia, diminished the effects of hypoxia on p62 mRNA. At the post-translational level, the proteasome inhibitor MG132, but not the lysosomal inhibitors ammonium chloride and bafilomycin, prevented the hypoxic depletion of p62, suggesting the involvement of the proteasome pathway. Under hypoxia, the expression of the E3 ubiquitin ligase Parkin was up-regulated in a hypoxia-inducible factor 1α-dependent manner. Parkin ubiquitinated p62 and led to its proteasomal degradation, ensuring low levels of p62 under hypoxia. We demonstrated that the effects of Parkin on p62 required heat shock cognate 71 kDa protein (Hsc70). We also showed that the overexpression of Nrf2 and knockdown of Parkin or Hsc70 induced the accumulation of p62 and reduced the viability of cells under hypoxia. We concluded that a decrease in p62, which involves regulation at the transcriptional and post-translational levels, is critical for cell survival under hypoxia. The present results show the potential of targeting Nrf2/Parkin-Hsc70-p62 as a novel strategy to eradicate hypoxic solid tumors.
Bayesian model and selection signature analyses reveal risk factors for canine atopic dermatitis
Authors: Tengvall Katarina , Sundström Elisabeth , Wang Chao , Bergvall Kerstin , Wallerman Ola , Pederson Eric , Karlsson Åsa , Harvey Naomi D. , Blott Sarah C. , Olby Natasha , Olivry Thierry , Brander Gustaf , Meadows Jennifer R. S. , Roosje Petra , Leeb Tosso , Hedhammar Åke , Andersson Göran , Lindblad-Toh Kerstin 
Published: December 2022

AbstractCanine atopic dermatitis is an inflammatory skin disease with clinical similarities to human atopic dermatitis. Several dog breeds are at increased risk for developing this disease but previous genetic associations are poorly defined. To identify additional genetic risk factors for canine atopic dermatitis, we here apply a Bayesian mixture model adapted for mapping complex traits and a cross-population extended haplotype test to search for disease-associated loci and selective sweeps in four dog breeds at risk for atopic dermatitis. We define 15 associated loci and eight candidate regions under selection by comparing cases with controls. One associated locus is syntenic to the major genetic risk locus (Filaggrinlocus) in human atopic dermatitis. One selection signal in common type Labrador retriever cases positions across theTBC1D1gene (body weight) and one signal of selection in working type German shepherd controls overlaps theLRP1Bgene (brain), near theKYNUgene (psoriasis). In conclusion, we identify candidate genes, including genes belonging to the same biological pathways across multiple loci, with potential relevance to the pathogenesis of canine atopic dermatitis. The results show genetic similarities between dog and human atopic dermatitis, and future across-species genetic comparisons are hereby further motivated.
Controlled release of growth factors using synthetic glycosaminoglycans in a modular macroporous scaffold for tissue regeneration
Authors: Söderlund Z. , Ibáñez-Fonseca A. , Hajizadeh S. , Rodríguez-Cabello J. C. , Liu J. , Ye L. , Tykesson E. , Elowsson L. , Westergren-Thorsson G. 
Published: December 2022

AbstractHealthy regeneration of tissue relies on a well-orchestrated release of growth factors. Herein, we show the use of synthetic glycosaminoglycans for controlled binding and release of growth factors to induce a desired cellular response. First, we screened glycosaminoglycans with growth factors of interest to determine kon (association rate constant), koff (dissociation rate constant), and Kd (equilibrium rate constant). As proof-of-concept, we functionalized an elastin-like recombinamer (ELR) hydrogel with a synthetic glycosaminoglycan and immobilized fibroblast growth factor 2 (FGF2), demonstrating that human umbilical vein endothelial cells cultured on top of ELR hydrogel differentiated into tube-like structures. Taking this concept further, we developed a tunable macroporous ELR cryogel material, containing a synthetic glycosaminoglycan and FGF2 that showed increased blood vessel formation and reduced immune response compared to control when implanted in a subcutaneous mouse model. These results demonstrated the possibility for specific release of desired growth factors in/from a modular 3D scaffold in vitro and in vivo.
Supporting COVID-19 policy-making with a predictive epidemiological multi-model warning system
Authors: Bicher Martin , Zuba Martin , Rainer Lukas , Bachner Florian , Rippinger Claire , Ostermann Herwig , Popper Nikolas , Thurner Stefan , Klimek Peter 
Published: December 2022

Abstract
Background
In response to the SARS-CoV-2 pandemic, the Austrian governmental crisis unit commissioned a forecast consortium with regularly projections of case numbers and demand for hospital beds. The goal was to assess how likely Austrian ICUs would become overburdened with COVID-19 patients in the upcoming weeks.

Methods
We consolidated the output of three epidemiological models (ranging from agent-based micro simulation to parsimonious compartmental models) and published weekly short-term forecasts for the number of confirmed cases as well as estimates and upper bounds for the required hospital beds.

Results
We report on three key contributions by which our forecasting and reporting system has helped shaping Austria’s policy to navigate the crisis, namely (i) when and where case numbers and bed occupancy are expected to peak during multiple waves, (ii) whether to ease or strengthen non-pharmaceutical intervention in response to changing incidences, and (iii) how to provide hospital managers guidance to plan health-care capacities.

Conclusions
Complex mathematical epidemiological models play an important role in guiding governmental responses during pandemic crises, in particular when they are used as a monitoring system to detect epidemiological change points.
Predominant SARS-CoV-2 variant impacts accuracy when screening for infection using exhaled breath vapor
Authors: McCartney Mitchell M. , Borras Eva , Rojas Dante E. , Hicks Tristan L. , Hamera Katherine L. , Tran Nam K. , Tham Tina , Juarez Maya M. , Lopez Enrique , Kenyon Nicholas J. , Davis Cristina E. 
Published: December 2022

Abstract
Background
New technologies with novel and ambitious approaches are being developed to diagnose or screen for SARS-CoV-2, including breath tests. The US FDA approved the first breath test for COVID-19 under emergency use authorization in April 2022. Most breath-based assays measure volatile metabolites exhaled by persons to identify a host response to infection. We hypothesized that the breathprint of COVID-19 fluctuated after Omicron became the primary variant of transmission over the Delta variant.

Methods
We collected breath samples from 142 persons with and without a confirmed COVID-19 infection during the Delta and Omicron waves. Breath samples were analyzed by gas chromatography-mass spectrometry.

Results
Here we show that based on 63 exhaled compounds, a general COVID-19 model had an accuracy of 0.73 ± 0.06, which improved to 0.82 ± 0.12 when modeling only the Delta wave, and 0.84 ± 0.06 for the Omicron wave. The specificity improved for the Delta and Omicron models (0.79 ± 0.21 and 0.74 ± 0.12, respectively) relative to the general model (0.61 ± 0.13).

Conclusions
We report that the volatile signature of COVID-19 in breath differs between the Delta-predominant and Omicron-predominant variant waves, and accuracies improve when samples from these waves are modeled separately rather than as one universal approach. Our findings have important implications for groups developing breath-based assays for COVID-19 and other respiratory pathogens, as the host response to infection may significantly differ depending on variants or subtypes.
Sensory Inhibition and Speech Perception-in-Noise Performance in Children With Normal Hearing
Authors: Campbell Julia , Rouse Rixon , Nielsen Mashhood , Potter Sheri 
Published: December 2022

Purpose:
This study investigated whether sensory inhibition in children may be associated with speech perception-in-noise performance. Additionally, gating networks associated with sensory inhibition were identified via standardized low-resolution brain electromagnetic tomography (sLORETA), and the detectability of the cortical auditory evoked potential (CAEP) N1 response was enhanced using a 4- to 30-Hz bandpass filter.

Method:
CAEP gating responses, reflective of inhibition, were evoked via click pairs and recorded using high-density electroencephalography in neurotypical 5- to 8-year-olds and 22- to 24-year-olds. Amplitude gating indices were calculated and correlated with speech perception in noise. Gating generators were estimated using sLORETA. A 4- to 30-Hz filter was applied to detect the N1 gating component.

Results:
Preliminary findings indicate children showed reduced gating, but there was a correlational trend between better speech perception and decreased N2 gating. Commensurate with decreased gating, children presented with incomplete compensatory gating networks. The 4- to 30-Hz filter identified the N1 response in a subset of children.

Conclusions:
There was a tenuous relationship between children's speech perception and sensory inhibition. This may suggest that sensory inhibition is only implicated in atypically poor speech perception. Finally, the 4- to 30-Hz filter settings are critical in N1 detectability.

Significance:
Gating may help evaluate reduced sensory inhibition in children with clinically poor speech perception using the appropriate methodology. Cortical gating generators in typically developing children are also newly identified.
Novel compact waveguide filtering twist for computer numerical control machining
Authors: Zhang Yi , Shang Xiaobang , Xu Jun , Guo Yuewei , Duan Lei , Lu Xiao 
Published: December 2022

AbstractIn this letter, the authors present a novel compact waveguide filtering twist that can be readily fabricated from metal using the computer numerical control (CNC) machining process. This filtering twist comprises four coupled resonators that are rotationally deformed to provide the desired 90° twist. Such resonator structures eliminate the use of curved features and therefore are ideally suitable for conventional CNC machining. The proposed design offers appealing advantages, including great compactness, easy fabrication, and good scalability to millimetre‐wave and terahertz frequencies. The design is demonstrated at X‐band and has a fourth‐order Chebyshev filter response (bandwidth 0.4 GHz, centred at 10 GHz). The good agreement between simulation and measurement results validates the proposed concept.
A novel high‐voltage solid‐state switch based on the SiC MOSFET series and its overcurrent protection
Authors: He Dazhao , Sun Wenjie , Liao Yixin , Zhang Penghao , Yu Liang , Dong Shoulong , Yao Chenguo , liu Xin 
Published: December 2022

AbstractAll‐solid‐state switches are one of the core components of pulsed power supply systems. However, the voltage level of a single switch is limited. By optimizing the chip structure, the voltage level of a single switch can be improved. Due to the immaturity of the production process and the positive correlation between the blocking voltage and the on‐resistance of the switch, it is difficult to improve the blocking voltage and the continuous forward current of a single switch simultaneously. The series‐connected switch is a way to increase the switch's blocking voltage without reducing the switch's continuous forward current. Magnetically coupled isolated drive and resistor‐capacitor forced voltage equalization techniques are investigated to increase the blocking voltage of the switches using multiple SiC metal‐oxide‐semiconductor field‐effect transistors (MOSFETs) in series connections. Meanwhile, a special overcurrent protection scheme is designed to improve the reliability of the series‐connected switch. Finally, a high‐voltage solid‐state switch is developed based on the SiC MOSFET series connections, whose output pulse width is adjustable from 20 to 300 μs, frequency is adjustable from 1 Hz to 3 kHz, the maximum output voltage can reach 57 kV (1 Hz), and the overcurrent protection time is about 1 μs.
Low‐carbon economic dispatch of the combined heat and power‐virtual power plants: A improved deep reinforcement learning‐based approach
Authors: Tan Yongqiang , Shen Yanxia , Yu Xinyan , Lu Xin 
Published: December 2022

AbstractTo realize the national strategies for carbon emission reduction, electric power industries should undergo reforms to cope with the multiple challenges of decarbonization, marketization, and energy transition. How to design a dispatch strategy that considers both low‐carbon demand and economic cost has become a major concern in integrated energy systems. To realize multi‐energy complementation and low‐carbonization, a scheduling framework of combined heat and power‐virtual power plants (CHP‐VPPs) considering carbon capture and power‐to‐gas is proposed. The stochastic dynamic optimization problem is modelled as a Markov decision process. An improved deep reinforcement learning‐based algorithm named multi‐level backtracking prioritized experience replay‐twin delayed deep deterministic policy gradient (MBEPR‐TD3) is employed to solve the low‐carbon economic dispatch problem. The results show that: (1) The profits have been increased by 85.8% and carbon emissions have been reduced by 30.3% because of the addition of power‐to‐gas in CHP‐VPP; (2) the revenues have been improved by 22.24% and carbon emissions have been decreased by 37.04% owing to the introduction of carbon capture and trading; (3) compared with results using DQN, DDPG, and TD3, the optimal dispatch strategy obtained by MBEPR‐TD3 has higher reward returns and more stable convergence.
Nonoperative Treatment of Single-Tendon Proximal Hamstring Avulsions
in Recreational Athletes
Authors: Bono Olivia J. , Forlizzi Julianne , Shah Sarav S , Nacca Christopher R. , Manz Eric , Ives Katharine , Miller Suzanne L. 
Published: December 2022

AbstractThe purpose of this study was to evaluate the patient-reported and objective
functional outcomes of those patients who underwent nonoperative management of a
single-tendon retracted proximal hamstring avulsion. A retrospective case series
of consecutive patients with an MRI-confirmed diagnosis of single-tendon
proximal hamstring avulsion treated nonoperatively with at least one year of
follow-up was performed. Patient-reported outcome measures (PROMs) including
SF-12v2, Lower Extremity Functional Score (LEFS), Hip Outcome Score-activities
of daily living and sport subscale (HOS-ADL, HOS-SS) were prospectively
collected. Objective measurements included strength testing of the affected and
unaffected limbs with a handheld dynamometer and single-leg hop test.
Student’s t-tests were used to determine differences between limbs.
Eleven of fourteen patients were available for PROMs (79%); five
completed functional testing. Subjective scores revealed a mean SF-12v2 mental
component score of 56.53±8.2, and a physical component score of
50.1±12.7. LEFS was 84%±19.8, HOS-ADL
87.9%±17.2, and HOS-SS 80.9%±24. The differences
between limbs were not statistically significant for strength at 45 or 90
degrees of knee flexion, nor for single-leg hop distance. Patients in a
non-professional athlete population who undergo nonoperative management of
single-tendon retracted proximal hamstring avulsions can expect good subjective
and objective outcomes.
It Is Not Only the Meniscus That Flips—A Case of TFCC Tear with a Flipped Fragment in the Distal Radioulnar Joint
Authors: Agarwal Aakanksha , Chandra Abhishek , Murray Timothy , Cresswell Mark 
Published: December 2022

AbstractAcute wrist injuries with ongoing ulnar-sided wrist pain warrant a magnetic resonance imaging (MRI) to diagnose ligamentous injuries. Triangular fibrocartilage complex (TFCC) tears have been classified and described in the literature but complex tear patterns have limited representation. Bucket-handle tears of the TFCC represent only 0.5% of TFCC tears and have recently been identified, posing a diagnostic and management challenge. Preoperative diagnosis is possible with MRI and necessary for optimal and early surgical management. The authors describe a unique case of a flipped tear of the central disc of the TFCC, where the fragment was flipped into the distal radioulnar joint, a site hidden during routine arthroscopy.
What is it (like) to imagine an emotion?
Authors: Loev Slawa , Inchingolo Marco , Velasco Pablo Fernandez 
Published: December 2022

AbstractWhat does it mean to imagine an emotion? The present article introduces a typology of three different ways in which it is possible to imagine emotion. This typology allows to individuate a form of imagining emotion that has been underexplored: emotion-like imagination. Emotion-like imagination, rather than being a way of merely imagining that a certain emotional experience occurs or a form of responding emotionally to imagined representations, requires a subject to re-enact the emotional state itself so that the imagining has emotional phenomenal properties as its main content. We go on to provide a first in-depth exploration of emotion-like imagination, suggesting emotion regulation mechanisms as the empirical grounds for its cognitive realizability. Finally, we sketch how emotion-like imagination can fruitfully complement discussions of affective forecasting and empathetic understanding.
Layer-stacking of chalcogenide-terminated MXenes Ti2CT2(T = O, S, Se, Te) and their applications in metal-ion batteries
Authors: Nie Xiaomin , Ji Yujin , Ding Yi-min , Li Youyong 
Published: December 2022

Abstract
Owning to limited supply of lithium for Li-ion batteries, the development of non-Li-ion batteries (such as Na+, K+ Mg2+, Ca2+, and Al3+ ion batteries) has attracted significant research interest. In this work, by means of the first-principles calculations, we systematically investigated the performance of chalcogenide-terminated MXenes Ti2CT2 (T = O, S, Se, and Te) as electrodes for Li-ion and non-Li-ion batteries, as well as the layer-stacking and electronic properties of Ti2CT2. We find that the stacking type of O and Te terminated Ti2C multilayers with AA stacking differs from that of S and Se terminated Ti2C multilayers with AB stacking. More importantly, Ti2CO2 monolayer can be potential anode material for Na- and K-ion batteries with high capacities and very low diffusion barriers (0.03–0.11 eV), while Ti2CS2 and Ti2CSe2 are promising anode materials with relatively low average open circuit voltages (OCVs) for Na-, K-, and Ca-ion batteries (0.4–0.87 V). Among these materials, Ti2CS2 exhibits the largest ion capacity of 616 mAh g−1. These results of our work may inspire further studies of Ti2C-MXenes multilayers as electrodes for metal-ion batteries either experimentally or theoretically.
New cross-section measurements for the (n, 2n), (n, p), and (n, α) reactions on bromine in the 14 MeV region with detailed uncertainty quantification*
Authors: He Long , Luo Junhua , Jiang Li 
Published: December 2022

Abstract
Measurement of the cross-sections of the 79Br(n, 2n)78Br, 81Br(n, p)81mSe, 81Br(n, α)78As, and 79Br(n, α)76As reactions was performed at specific neutron energies, precisely, 13.5±0.2, 14.1±0.2, 14.4±0.2, and 14.8±0.2 MeV, relative to the standard 93Nb(n, 2n)92mNb and 27Al(n, α)24Na reference reactions using offline γ-ray spectrometry and neutron activation. Monoenergetic neutrons were generated at the China Academy of Engineering Physics via a 3H(d, n)4He reaction using the K-400 Neutron Generator equipped with a solid 3H-Ti based target. The activity of the reaction produce was obtained using a high-purity germanium detector. The cross-sections of the (n, 2n), (n, p), and (n, α) reactions on the bromine isotopes were measured in the 13–15 MeV neutron energy range. The covariance analysis approach was employed for a thorough inspection of any uncertainties within the measured cross-section data. A discussion and comparison of the observed outcome were carried out with previously published data, especially with the results of the JENDL-4.0, JEFF-3.3, TENDL-2019, and ENDF/B-VIII.0 data libraries, along with the theoretical excitation function curve derived by employing the TALYS-1.95 program. Improved cross-section restrictions for the investigated processes in the 13–15 MeV neutron energy range will be obtained using the current findings, which will help to raise the caliber of associated databases. Furthermore, the parameters of relevant nuclear reaction models can be verified using this data.