bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibrinolysis in COVID-19: Impact on Clot Lysis and Modulation of Inflammation
Authors: Sousa Lirlândia P. , Sugimoto Michelle A. , Perucci Luiza O. , Tavares Luciana P. , Teixeira Mauro M. 
Published: October 2022

Abstract:COVID-19 is a multisystem disease caused by SARS-CoV-2 and is associated with an imbalance between the coagulation and fibrinolytic systems. Overall, hypercoagulation, hypofibri-nolysis and fibrin-clot resistance to fibrinolysis predispose patients to thrombotic and thromboem-bolic events. In the lungs, the virus triggers alveolar and interstitial fibrin deposition, endothelial dysfunction, and pulmonary intravascular coagulation, all events intrinsically associated with the activation of inflammation and organ injury. Adding to the pathogenesis of COVID-19, there is a positive feedback loop by which local fibrin deposition in the lungs can fuel inflammation and con-sequently dysregulates coagulation, a process known as immunothrombosis. Therefore, fibrinolysis plays a central role in maintaining hemostasis and tissue homeostasis during COVID-19 by cleaning fibrin clots and controlling feed-forward products of coagulation. In addition, components of the fi-brinolytic system have important immunomodulatory roles, as evidenced by studies showing the contribution of Plasminogen/Plasmin (Plg/Pla) to the resolution of inflammation. Herein, we review clinical evidence for the dysregulation of the fibrinolytic system and discuss its contribution to thrombosis risk and exacerbated inflammation in severe COVID-19. We also discuss the current concept of an interplay between fibrinolysis and inflammation resolution, mirroring the well-known crosstalk between inflammation and coagulation. Finally, we consider the central role of the Plg/Pla system in resolving thromboinflammation, drawing attention to the overlooked consequences of COVID-19-associated fibrinolytic abnormalities to local and systemic inflammation.
Preparation of Loratadine Orally Disintegrating Tablets by Semi-solid
Extrusion 3D Printing
Authors: Yi Shaoling , Xie Jingwen , Chen Lingli , Xu Feng 
Published: October 2022

Background:
The orally disintegrating tablets (ODTs) are especially suitable for elders and children with dysphagia, who need to be customized dosages.

Objectives:
This study aimed to prepare orally disintegrating tablets (ODTs) which can be customized as drug content by using semi-solid 3D printing pressure extrusion technology, with water insoluble and thermally unstable drug loratadine.

Methods:
The influence of binder concentration, disintegrating agent dosage and ratio mannitol: cellulose on formability and disintegration time was investigated. The properties of orally disintegrating tablets were investigated by ATR-FTIR, XRPD, DSC and SEM. The correlation formula between tablet bottom area and drug content was established.

Results:
The formulation was optimized, and contained loratadine 3 g, cellulose 4 g, mannitol 2 g, carboxy methyl starch sodium 1g, 6% PVP K30 16 ml. The disintegration time was less than 60 s with a infilling percentage of 60%, and the disintegration time was less than 30 s with a infilling percentage of 40%. There was no detectable interaction between loratadine and the selected excipients by the analysis of ATR-FTIR, DSC and XRPD. The structure of the tablets was porous, and the drug was dissolved completely within 10 min. The drug content (x) of the tablet and the bottom area (y) of the tablet showed a linear fitting relationship, y = 3.8603x - 0.7176, r2 = 0.9993.

Conclusion:
Semi-solid extrusion of 3D printing technology was applied to prepare loratadine orally disintegrating tablets with customized drug content, which provides an alternative method for the research of customized preparation.
Synovial Chondromatosis of the Shoulder in Rheumatoid Arthritis: A Case
Report and Brief Review of the Literature
Authors: Tekaya Aicha Ben , Hamdi Ons , Bellil Mehdi , Saidane Olfa , Rouached Leila , Bouden Selma , Tekaya Rawdha , Salah Mohamed Ben , Mahmoud Ines , Abdelmoula Leila 
Published: October 2022

Background:
Synovial chondromatosis is an uncommon benign condition characterized by synovial membrane proliferation and metaplasia. Synovial chondromatosis cases in patients with rheumatoid arthritis have been reported. However, involvement of the glenohumeral joint is rare.

Case presentation:
We herein report a case of a rare association of synovial chondromatosis involving the shoulder in a rheumatoid arthritis patient. The symptoms have improved with anti-tumor necrosis factor drugs. Consequently, there was no need for invasive therapy for treating synovial chondromatosis.

Conclusions:
Synovial chondromatosis can be aggressive and destructive. More trials are needed to establish a better clinical diagnostic strategy and pharmacological management.
Pseudocereals: Nutrition, Health Benefits, and Potential Applications in
Gluten-free Food Product Developments
Authors: Wanniarachchi Piyumi Chathurangi , Pavalakumar Dayani , Jayasinghe Madhura Arunoda 
Published: October 2022

Abstract:
Since the dawn of time, cereals have been acknowledged to play a critical role in meeting human food demand as they are capable of providing significant amounts of macro and micronutrients and calories to an individual’s diet. Pseudocereals, on the other hand, are also naturally high in these critical nutrients but have not been fully investigated for their ability to be used in large-scale manufacturing activities. Although pseudocereals grains provide a reasonable advantage to their users, in terms of nutrition and health benefits many people, still people do not get the whole advantage out of them. Pseudocereals are edible seeds from the class Dicotyledonae, and represent increasingly popular gluten-free grains with high nutritional value in human diets. Pseudocereals are high in starch, fiber, proteins, minerals, vitamins, and phytochemicals (especially phenolics) which dispense profuse health benefits. They can lower the risk of chronic diseases such as diabetes, cancer, and cardiovascular diseases. Therefore, this work aims to provide an outline of the major types, nutritional and phytochemical composition, health benefits, and potential applications of the three most commonly consumed pseudocereal grains: amaranth, quinoa, and buckwheat to popularize these grains among people. Commercialization of these pseudocereals containing products would aid in combating a variety of health-related issues. Amaranth, quinoa, and buckwheat are gluten-free sources and contain no prolamins that are harmful to celiac disease patients. Therefore, pseudocereal-incorporated gluten-free foods would symbolize a step forward in guaranteeing sufficient input of nutrients in celiac disease patients.
Computational Analysis of Bacopa monnieri (L.) Wettst. Compounds for
Drug Development against Neurodegenerative Disorders
Authors: Sangeet Satyam , Khan Arshad , Mahanta Saurov , Roy Nabamita , Das Sanjib Kumar , Mohanta Yugal Kishore , Saravanan Muthupandian , Tag Hui , Hui Pallabi Kalita 
Published: October 2022

Aim:
With several experimental studies establishing the role of Bacopa monnieri as an effective
neurological medication, less focus has been employed to explore how effectively Bacopa monnieri brings
about this property. The current work focuses on understanding the molecular interaction of the phytochemicals
of the plant against different neurotrophic factors to explore their role and potential as potent
anti-neurodegenerative drugs.

Background:
Neurotrophins play a crucial role in the development and regulation of neurons. Alterations
in the functioning of these Neurotrophins lead to several Neurodegenerative Disorders. Albeit engineered
medications are accessible for the treatment of Neurodegenerative Disorders, due to their numerous side
effects, it becomes imperative to formulate and synthesize novel drug candidates.

Objective:
This study aims to investigate the potential of Bacopa monnieri phytochemicals as potent antineurodegenerative
drugs by inspecting the interactions between Neurotrophins and target proteins.

Methods:
The current study employs molecular docking and molecular dynamic simulation studies to examine
the molecular interactions of phytochemicals with respective Neurotrophins. Further inspection of
the screened phytochemicals was performed to analyze the ADME-Tox properties in order to classify the
screened phytochemicals as potent drug candidates.

Results:
The phytochemicals of Bacopa monnieri were subjected to in-silico docking with the respective
Neurotrophins. Vitamin E, Benzene propanoic acid, 3,5-bis (1,1- dimethylethyl)- 4hydroxy-, methyl ester
(BPA), Stigmasterol, and Nonacosane showed an excellent binding affinity with their respective Neurotrophins
(BDNF, NT3, NT4, NGF). Moreover, the molecular dynamic simulation studies revealed that BPA
and Stigmasterol show a very stable interaction with NT3 and NT4, respectively, suggesting their potential
role as a drug candidate. Nonacosane exhibited a fluctuating binding behavior with NGF which can be accounted
for by its long linear structure. ADME-Tox studies further confirmed the potency of these phytochemicals
as BPA violated no factors and Vitamin E, Stigmasterol and Nonacosane violated 1 factor for
Lipinski’s rule. Moreover, their high human intestinal absorption and bioavailability score along with their
classification as non-mutagen in the Ames test makes these compounds more reliable as potent antineurodegenerative
drugs.

Conclusion:
Our study provides an in-silico approach toward understanding the anti-neurodegenerative
property of Bacopa monnieri phytochemicals and establishes the role of four major phytochemicals which
can be utilized as a replacement for synthetic drugs against several neurodegenerative disorders.
Analytical and Bioanalytical Methods for the Quantification of the Nucleotide
Polymerase Inhibitor - Sofosbuvir: A Critical Review (2015-2021)
Authors: Pathak Shilpi , Bhardwaj Muskan , Godela Ramreddy 
Published: October 2022

Abstract:
Sofosbuvir is a regularly used antiviral medication that was approved for clinical usage in hepatitis C patients. Sofosbuvir belongs to the nucleotide analog drug class, and it operates by inhibiting hepatitis C NS5B protein. This study focuses on the many analytical methods for detecting and quantifying Sofosbuvir in pharmaceutical formulations, biological samples, and fixed dosage combinations. Chromatographic techniques, electro-analytical methods, chemometric procedures, and optical approaches are just a few of the approaches mentioned in the literature. The most often used methods for the analysis of Sofosbuvir are HPLC-based methods with UV/Vis spectrophotometric, fluorescence, and mass spectrometric detection. This article could be extremely useful in the creation of upcoming Sofosbuvir analytical approaches or investigations.
Animal Models and Methods of Myocardial Infarction Induction and the
Role of Tissue Engineering in the Regeneration of Damaged Myocardium
Authors: Fakhr Massoumeh Jabbari , Dezfouli Mohammad Reza Mokhber , Chaleshtori Sirous Sadeghian 
Published: October 2022

Abstract:
Introduction of an animal experimental model for myocardial infarction (MI) has particular importance. Research done on large animals provides valuable information for the researchers because of the similar characteristics of their hearts compared with human, but the cost of purchasing and maintenance of them is high. In comparison, using small animals has advantages such as they are easy to work with and have low purchase and maintenance cost. However, in some of these animals, due to less similarity of the heart to human, cannot simulate the natural pathogenesis of human MI. Moreover, there are different methods for induction of MI in animals, each has its own advantages and disadvantages. However, the method must be chosen that can simulate the natural pathogenesis of MI with minimal complication. Today, attempts are being made for myocardial regeneration after MI using the direct transplantation of stem cells or with an engineered scaffold. The scaffold creates a 3D ambience for the cultured cells. The task of tissue engineering is to optimize the scaffold with appropriate systems for separation, proliferation, and differentiation of the desired cells until they are capable to promote the three-dimensional and appropriate growth of the tissue.The purpose of tissue engineering in cardiac is use of scaffold and cell in the damaged area, followed by the improvement of the heart function through the automatic pulsation, communication with the host vessels, and electrical coupling with the myocardium, eventually creating a force to increase the heart function.
Effect of Online Training in the Continuing Education of Nurses in Hospitals in the Casablanca-Settat Region
Authors: Lhbibani Amina , Daaif Jabran , Lotfi Said , Tridane Malika , Belaaouad Said 
Published: October 2022

Context:
Nowadays, e-Learning has become essential for the continuing education of health professionals, especially in developing countries. Its introduction in health care settings guarantees better opportunities for disseminating knowledge and skills.

Objective:
This study aimed to measure the effects of online training “E-learning” on the learning outcomes of nurses in two hospitals in the Casablanca-Settat region with the course “Health planning” as a training theme.

Methods:
This study is an experimental type, including an experimental group that benefited from online training (B, n2 = 30) and a Control group that benefited from face-to-face training (A, n1 = 30). We used a questionnaire to evaluate the nurses' knowledge (general and procedural) in pre and post-training and a questionnaire to evaluate the nurses' satisfaction with using e-learning in continuing education.

Results:
The results show a positive effect of online training on nurses' learning through an increase in knowledge (general and procedural) after comparing the average score in pre and post-training (The p-value is less than 0.05). Also, high satisfaction with the content covered, the methodology used in the e-Learning, and the quality of the platform.

Conclusion:
These results should encourage and motivate those responsible for continuing education to adopt online training as a complementary and promising solution to ensure flexible and continuous continuing education sessions for healthcare personnel.
Perceptions and Experiences of Males who have Sex with Men Regarding Sexual and Reproductive Health Services in Bulawayo, Zimbabwe
Authors: Munyimani Tadios , Nunu Wilfred Njabulo 
Published: October 2022

Background:
Sexual and Reproductive Health services are a cornerstone for each nation to achieve Sustainable Development Goal Number 3, which challenges nations to ensure healthy lives and promote the well-being of all ages, including access to SRH services. Generally, stigma and policies against men who have sex with men have heightened the risk of getting and spreading sexually transmitted diseases in this key population. This study, therefore, sought to explore men who have sex with men's perceptions and experiences of sexual and reproductive health services offered in Bulawayo in Zimbabwe.

Methods:
An exploratory, descriptive qualitative study was conducted on twenty-four (24) purposively selected men who had sex with men identified through Sexual Rights Centre in Bulawayo. The study participants responded to unstructured interview questions that probed on their lived experiences and perceptions of sexual and reproductive health services offered by health facilities in the city of Bulawayo. The interviews were recorded, transcribed verbatim, coded, and thematically analyzed on MAXQDA Version 20 Pro.

Results:
Findings suggested that men who had sex with men sought a wider range of sexual and reproductive health services that ranged from voluntary counseling and testing, treatment of sexually transmitted infections, and obtaining pre-exposure prophylaxis tablets, among other issues. However, men who had sex with men faced discrimination, stigma, and hostile treatment by some health service providers. This scenario, in some instances, is perceived to have fueled their vulnerability and led to internalized homophobia.

Conclusion:
In pursuit of Sustainable Development Goal Number 3, which challenges all nations to ensure healthy lives and promote well-being at all ages, men who have sex with men are not fully accorded their rights. Therefore, there is a need to reorient health services and align policies to ensure the inclusion of this key population in accessing and utilizing sexual and reproductive health services.
A New Design for Low Flange-wear Railroad Wheelset
Authors: Yao Huiming , Gao Wudi , Yuan Chunping 
Published: October 2022

Background:
The wear of wheelsets on curves has always been a problem for rail vehicles; it
is of great significance to research and develop radial components with excellent curve negotiating performance.

Objective:
This paper aims to study and design a wheelset with excellent curve negotiating performance
to reduce wear on the flange. In addition, the dynamic simulation performance of the wheelset is studied.

Methods:
The wheel is divided into the flange part and the tread part; bearings are mounted between the
two, allowing them to rotate at differential speeds, while the tread part maintains a rigid connection with
the axle. Modeling and dynamics simulation of the wheelset is carried out by SOLIDWORKS and
SIMPACK.

Results:
Based on the Archard wear model, it is found that the flange wear amount of the designed
wheelset is significantly reduced compared with the traditional wheelset.

Conclusion:
The results show that the structural design of the wheelset is reasonable, has good curve
negotiating performance, and can greatly reduce the wear of the flange; however, there is still room for
further optimization of the structural design.
Extracción de pectina a partir de la hidrólisis ácida del cacao (Theobroma Cacao L.) y su aplicación en la obtención de biopelículas
Authors: Rodriguez Daniel , Ramirez Garcés Andres Felipe , Altamar Consuegra Astrid del Socorro 
Published: October 2022

Diferentes condiciones experimentales fueron empleadas para evaluar el tipo de ácido y el pH adecuados para la extracción de pectina a partir de cáscaras de cacao y su aplicación en la obtención de una biopelicula. Se estudió tipo de ácido: clorhídrico y cítrico, y el pH a niveles 2, 3 y 4 a una temperatura constante de 90°C, las variables respuestas fueron: rendimiento de pectina, % de metoxilo % de esterificación, % de ácido galacturónico y % de acidez. En las extracciones de pectina, se reportó un rendimiento promedio de ácido cítrico para un pH de 2.0 de 2.17%; para un pH 3.0 de 2.56% y el pH de 4.0 de 1.03%; para el ácido clorhídrico se reportó un rendimiento promedio con pH 2.0 de 2.68%; para un pH de 3.0 de 2.13% y para un pH de 4.0 un rendimiento de 0.83%. La pectina fue caracterizada mediante la técnica de Owens para evaluar variables de acidez libre, peso equivalente y grado de esterificación, adicionalmente se realizó un análisis FTIR para conocer los grupos funcionales. Basados en el análisis del diseño experimental utilizado, se seleccionó la pectina de mejores características para la fabricación de la biopelícula mediante la mezcla de pectina con glicerina como agente plastificante. Se sometió la biopelícula a prueba de biodegradabilidad aerobia, según lo expuesto en la norma ISO 17556 de 2019 donde se obtuvo una pérdida de peso del 18,8% y producción de 53 mg de en 5 días, mostrando una buena capacidad de biodegradabilidad.
Foucault and Brown: Disciplinary Intersections
Authors: Clements Niki Kasumi 
Published: October 2022

From the 1981 “Sexuality and Solitude” to the 1982 “Le combat de la chasteté” to the 1984 History of Sexuality, Volume 2, Michel Foucault’s published works have long recognized the influence of the historian of late antiquity, Peter Brown. With the 2018 publication of Foucault’s draft of Les Aveux de la chair (Confessions of the Flesh) bearing no mention of Brown, the depth of this influence requires further elaboration. Despite Brown not appearing in the “Index of Modern Authors,” Confessions of the Flesh reflects Foucault’s debt to Brown for his readings of Augustine of Hippo and his conceptualizations of sexuality and subjectivity.
Analyzing archival evidence alongside biographical narratives helps us better understand Brown’s vital influence as Foucault was shifting his History of Sexuality project, his archival practices, and his genealogy of subjectivity. Appreciating the textual and conceptual engagement between Foucault and Brown thus illuminates not only Confessions of the Flesh as Volume 4 in the History of Sexuality series but also the conceptual and methodological developments of both scholars in their disciplinary intersections.
Efficacy and Safety of finerenone therapy in patients with cardiovascular and chronic kidney diseases in type 2 diabetes mellitus: a systematic review and meta-analysis
Authors: Khatri Mahima Khatri Mahima , Kumar Satesh , Saleem Kiran , Khalil Sidra , Ali Maria , Usman Muhammad , Khanzada Uroosh Tariq , Nadeem Taha , Tanveer Fatima , Kumar Rohit , karmani Vikash Kumar , kumar Sumeet 
Published: October 2022

Background and Aims: Finerenone, a nonsteroidal MR antagonist
(MRA), enhances renal and cardiovascular outcomes in patients with type
2 diabetes (T2DM). Finerenone’s safety and effectiveness in renal
function are debatable. This meta-analysis evaluates the efficacy and
safety of treatments for patients with diabetic kidney disease.
Methods: To find relevant RCTs, the databases PubMed, Embase,
and Google Scholar were searched. Finerenone’s effects were quantified
using estimated pooled mean differences (MDs) and relative risks with
95% confidence intervals (CIs).
Results: This meta-analysis combines seven double-blind trials
involving patients with CKD and type 2 diabetes who were randomly
assigned to finerenone or placebo. The primary efficacy time-to-event
outcomes were cardiovascular death, non-fatal myocardial infarction,
non-fatal stroke, heart failure hospitalization, kidney failure, a
sustained 57% decrease in estimated glomerular filtration rate from
baseline over 4 weeks, or renal death. In this meta-analysis of 39,995
patients, treatment with Finerenone was associated with a lower risk of
death due to cardiovascular and renal outcomes than placebo (RR = 0.86
[0.80, 0.93] p=0.0002; I2= 0%) and (RR = 0.56 [0.17, 1.82]
p=0.34; I2= 0%), respectively. Finerenone treatment was also associated
with a marginally lower risk of serious adverse events (RR = 0.95
[0.92, 0.97] p 0.0001; I2= 0%), but no overall difference in the
risk of adverse events was found between the two groups (RR = 1.00
[0.99, 1.01] p=0.56; I2= 0%).
Conclusion: The administration of finerenone decreases the
likelihood of end-stage kidney disease, renal failure, cardiovascular
death, and hospitalization. Therefore, we propose that patients with
T2DM and CKD undergo finerenone therapy.
Keywords: Diabetes, Chronic kidney disease, CKD, Cardiovascular
disease, Finerenone, Non-steroidal Mineralocorticoid receptor
antagonist, Meta-analysis, Systematic review