bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of drug survival for Recurrent switching between IL-17 inhibitors and TNF- inhibitors in patients with axial spondyloarthritis
Authors: El-sherif Sherine , Abdelati Abeer Ali , Lotfy Nesma Ahmed , Elnemr Rehab Abdelaal 
Published: November 2022

Abstract
Objective: We aimed to ascertain survival rates of TNF-inhibitors and IL17-inhibitors therapy, as well as the reasons and potential predictors for drug discontinuation and switching in patients with axSpA.
Methods: A longitudinal observational retrospective study was carried out on 148 patients with a clinical diagnosis of axSpA and were on TNF or IL-17 inhibitors recruited from June 2021 to September 2022. Drug survival was recorded as well as the frequency of and reasons for switching biological therapy were reported. Two types of models were used to investigate factors associated with recurrence of switching treatment: Poisson regression (for number of times patients switched treatment) and Cox model for recurrent event (for time to recurrence of switching to another treatment).
Results: The initial biologic taken was IL17-i in 103 patients, and TNF-i in the remaining 45. Disease duration (P=0.01), BMI (P=0.021) and elevated faecal calprotectin (P=0.000), appeared to significantly increase the number of switching with a rate ratio of 1.05, 1.01 and 3.64 respectively. Median drug survival time for the initial, second, and third biologic lines showed no significant difference (P= 0.136) between the three. Elevated faecal calprotectin level was significantly associated with lower survival of IL17-i, (HR: 3.5; P: 0.000). For TNF-i, elevated faecal calprotectin level and higher BMI were significantly associated with lower survival (HR= 4.36 and 1.04 respectively).
Conclusions: IL17-i has proved to have comparable survival to TNF-i in the management of a real-life heterogeneous cohort of axSpA patients irrespective of line of treatment. Increased BMI and faecal calprotectin were predictors of decreased TNF-i survival. Whereas only faecal calprotectin predicted decreased IL17-i survival.
Ecological compensation mechanism in Chinese river basins: Evidence from the prefecture-level administrative regions
Authors: Xie Huiming , Zheng Yaoqi , Zhang Bingbing 
Published: November 2022

Abstract
Different from previous studies which focused on provincial governments as the subjects of ecological compensation, we study the city-based ecological compensation mechanism in Chinese river basins. The value of water ecosystem service equivalents calculated based on remote sensing data is used to judge whether a city is an ecological protector or an ecological destroyer. The results showed that as time changed, the value of the water ecosystem service equivalents of different cities changed differently, and in the mass, the number of cities as ecological protectors was increasing and the ecological protectors showed agglomeration effect in space. Cities located on the edge of more than one river basin may have "dual identity", which means that they may be ecological protector for one basin but ecological destroyer for another basin. In words, it provides an open analytical framework for compensation standard negotiation based on the value of water ecosystem service equivalents from the perspective of cities in the transboundary compensation both inside and outside the basin.
On exp and log distributions in extensive and nonextensive statistical mechanics
Authors: Tawfik Abdel Nasser , Aboanbar Ahmed , Ghoneim Amira 
Published: November 2022

Abstract
In statistical physics, the dominance of Boltzmann--Gibbs distribution seems to endow an impression that this would be the only statistical approach. Indeed, there is a large class of statistical approaches referring to various types of nonextensivity. For instance, $\log$ and $\exp$ distributions play a crucial role in extensive and nonextensive statistical mechanics. Emerging in a physical system, Maxwell--Boltzmann statistics (MB) defines extensive entropy which relates the number of microstates to thermodynamic quantities. In this regard, the Boltzmann distribution is nothing but a probability distribution. The various types of nonextensive statistics categorically violate the fourth Shannon--Khinchen additivity. We compare between $\log$ and $\exp$ distributions in MB, Tsallis, and generic statistics and studied their mathematical properties. We conclude that their compatibility exclusively depends on the nonextensivity parameters.
PACS numbers: 05.70.Ln, 05.65.+b
A new approach for clinical translation of infrared spectroscopy: exploitation of the signature of glioblastoma for general brain tumor recognition
Authors: Steiner Gerald , Galli Roberta , Preusse Grit , Michen Susanne , Meinhardt Matthias , Temme Achim , Sobottka Stephan B. , Juratli Tareq A. , Koch Edmund , Schackert Gabriele , Kirsch Matthias , Uckermann Ortrud 
Published: November 2022

AbstractPurpose: Infrared (IR) spectroscopy has the potential for tumor delineation in neurosurgery. Previous research showed that IR spectra of brain tumors are generally characterized by reduced lipid-related and increased protein-related bands. Therefore, we propose the exploitation of these common spectral changes for brain tumor recognition. Methods: Attenuated total reflection IR spectroscopy was performed on fresh specimens of 790 patients within minutes after resection. Using principal component analysis and linear discriminant analysis, a classification model was developed on a subset of glioblastoma (n = 135) and non-neoplastic brain (n = 27) specimens, and then applied to classify the IR spectra of several types of brain tumors. Results: The model correctly classified 82% (517/628) of specimens as “tumor” or “non-tumor”, respectively. While the sensitivity was limited for infiltrative glioma, this approach recognized GBM (86%), other types of primary brain tumors (92%) and brain metastases (92%) with high accuracy and all non-tumor samples were correctly identified. Conclusion: The concept of differentiation of brain tumors from non-tumor brain based on a common spectroscopic tumor signature will accelerate clinical translation of infrared spectroscopy and related technologies. The surgeon could use a single instrument to detect a variety of brain tumor types intraoperatively in future clinical settings. Our data suggests that this would be associated with some risk of missing infiltrative regions or tumors, but not with the risk of removing non-tumor brain.
Decision-making power among women of reproductive age towards family planning use and its associated factors: A cross-sectional study in Simiyu region, Tanzania
Authors: Mkuwa Serafina , Shirima Laura J , Misungwi Gaspery , Mushy Stella E. , Sirili Sirili Nathanael , Ngalesoni Frida N 
Published: November 2022

Abstract

Background
One of the Sustainable Development Goals (SDGs) to be achieved by 2030 is to empower women in decision-making. It is universally agreeable that women's decision-making power influences their use of family planning. However, due to disparities in social and cultural norms and beliefs, the percentage of women with decision-making power varies across societies. Furthermore, unintended pregnancies and unsafe abortions have remained a public health concern, with serious consequences such as death, physical and mental complications, as well as social and economic problems for a woman and her family
Objective
To assess women’s decision-making power towards contraceptive use and its associated factors in Simiyu region.
Methodology:
The study utilizes data from a cross-sectional study conducted by Amref Health Africa among women of reproductive age in the Simiyu region. An interviewer-administered questionnaire was used for data collection. Stata 15 was used for data analysis. Categorical variables were summarized using frequency and percentage. The Chi-square test was used to compare the proportion of women’s decision-making power across independent variables. To identify factors associated with women's decision-making power regarding contraceptive use, a multinomial logistic regression model was used.
Results
A total of 917 women were investigated. Of these, 304 (33.1%) reported making their own decision on contraceptive use, 421 (45.9%) made a joint decision with their spouse, and 192 (20.9%) had their decision made by another person. Age, marital status, previous use of contraceptives, husbands using force for sex, and family planning being considered as women's health issues were all associated with women's decision-making power.
Critical Windows of Exposure to Air pollution and Gestational Diabetes: Assessing Effect Modification by Maternal Pre-Existing Conditions and Environmental Factors
Authors: Miron-Celis Marcel , Talarico Robert , Villeneuve Paul J. , Crighton Eric , Stieb David M. , Stanescu Cristina , Lavigne Éric 
Published: November 2022

Abstract
Background Ambient air pollution has been associated with gestational diabetes (GD), but critical windows of exposure and whether maternal pre-existing conditions and other environmental factors modify the associations remains inconclusive.
Methods We conducted a retrospective cohort study of all singleton live birth that occurred between April 1st 2006 and March 31st 2018 in Ontario, Canada. Ambient air pollution data (i.e., fine particulate matter with a diameter ≤ 2.5μm (PM2.5), nitrogen dioxide (NO2) and ozone (O3)) were assigned to the study population in spatial resolution of approximately 1 km x 1 km. The Normalized Difference Vegetation Index (NDVI) and the Green View Index (GVI) were also used to characterize residential exposure to green space as well as the Active Living Environments (ALE) index to represent the active living friendliness. Multivariable Cox proportional hazards regression models were used to evaluate the associations.
Results Among 1,310,807 pregnant individuals, 68,860 incident cases of GD were identified. We found the strongest associations between PM2.5 and GD in gestational weeks 7 to 18 (HR = 1.07 per IQR (2.7 µg/m3); 95% CI: 1.02 – 1.11)). For O3, we found two sensitive windows of exposure, with increased risk in the preconception period (HR = 1.03 per IQR increase (7.0 ppb) (95% CI: 1.01 – 1.06)) as well as gestational weeks 9 to 28 (HR 1.08 per IQR (95% CI: 1.04 –1.12)). We found that women with asthma were more at risk of GD when exposed to increasing levels of O3 (p- value for effect modification = 0.04). Exposure to air pollutants explained 20.1%, 1.4% and 4.6% of the associations between GVI, NDVI and ALE, respectively.
Conclusion An increase of PM2.5 exposure in early pregnancy and of O3 exposure during late first trimester and over the second trimester of pregnancy were associated with gestational diabetes whereas exposure to green space may confer a protective effect.
Efficient fully decoupled numerical schemes for the Cahn-Hilliard-Navier-Stokes phase field model
Authors: WU ZIBIN , YANG HUANHUAN 
Published: November 2022

Abstract
There are few fully decoupled, explicit but unconditionally stable numerical schemes for solving hydrodynamics coupled phase field models. In this paper, we propose two second-order, linear, fully decoupled schemes for the Cahn-Hilliard-Navier-Stokes phase field model based on the artificial compression method, the single / multiple scalar auxiliary variables approach, and a stabilization technique. Both schemes are proved to be unconditionally stable, and an efficient implementation only requires solving linear systems with a constant coefficient matrix at different time steps. Ample numerical experiments are performed to validate the accuracy, stability, and effciency of the proposed schemes.
Development of Novel Fouling-resistant Hollow Fibre Nanocomposite Membrane augmented with Iron oxide Nanoparticles for efficient Rejection of Bisphenol A from Water: Fouling, Permeability, and Mechanism Studies
Authors: Katibi Kamil Kayode , Yu Khairul Faezah Md , Man Hasfalina Che , Aris Ahmad Zaharin , Nor Mohd Zuhair Mohd , Azis Rabaah Syahidah , Goh Pei Sean , Zainuddin Norhazlin , Fauzi Ahmad Ismail 
Published: November 2022

Abstract
Recently, frequent discharge of water-ladened emerging organic pollutants such as Bisphenol A has generated serious concern owing to its harmful effects on public safety and the ecological environment. Hematite nanoparticles (Fe2O3) were synthesized via the sol-gel auto-combustion procedure and utilized as a nanofiller to fabricate a PVDF-PEG/Fe2O3 nanocomposite hollow fibre membrane with enhanced antifouling properties. A series of membranes comprising various loadings (1.0–2.0 wt.%) of Fe2O3 NPs were fabricated through the phase inversion technique and thoroughly analyzed. The developed Fe2O3-membrane fibres were thoroughly characterized. The performance of the membrane fibres was investigated through permeation flux, BPA rejection, as well as antifouling characteristics. Based on the results obtained, the resultant nanocomposite membrane fibres exhibited superior performance in comparison with the pristine fibre. Also, the nanocomposite membrane with 1.5 wt.%-Fe2O3 NPs exhibited remarkable performance with − 43.7 mV, 56.3º, 191.85 L/m2-h, 86.7%, and 12% of negatively charged zeta potential, least contact angle, water permeation flux, BPA rejection, and minimum weight loss, respectively. Besides, the 1.5 wt-Fe2O3 NPs nanocomposite membrane demonstrated superior antifouling performance after the third filtration, accomplishing a higher percent of FRR (77.35%) along with RFR of 21.29%, respectively. Hence, based on the performance of the fabricated hollow-fibre membranes loaded with Fe2O3 NPs, efficient antifouling membranes was achieved which can be suitably applied in the purification of industrial wastewater.
Carbapenem-resistant Klebsiella pneumoniae (CRKP) transfers conjugative plasmids containing blaNDM-5 and mcr-1 genes via outer membrane vesicles (OMVs)
Authors: Song Zhenli , Qin Yingcheng , Peng Yuan , Huang Mei , Hua Yuneng , Jiang Hongye , Hu Xiumei , Rui Yongyu 
Published: November 2022

Abstract
A carbapenem-resistant Klebsiella pneumoniae (CRKP) strain, NFYY0065, was isolated from a fecal sample obtained from hospitalized patients in Nanfang hospital. By performing whole genome sequencing (WGS), we revealed that NFYY0065 harbored blaNDM-5 and mcr-1 genes, which were located on the IncX3 plasmid (pAN65-3) and IncHI2 plasmid (pAN65-1), respectively. Transfer of the blaNDM-5-bearing plasmid and mcr-1-bearing plasmid from NFYY0065 to Escherichia coli J53 conferred resistance to common beta-lactams and colistin on the transconjugants, respectively. Outer membrane vesicles (OMVs) obtained from the NFYY0065 strain were confirmed by transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA). Purified vesicles harboring the blaNDM-5 and mcr-1 genes were confirmed by PCR/sequencing, and these OMVs derived from the NFYY0065 strain were transformed into ATCC700603 strains. The transformants were grown on co-antimicrobial plates (4 µg/ml meropenem and 4 µg/ml colistin), and further PCR/sequencing demonstrated that transformants carried the IncX3 plasmid and IncHI2 plasmid consistent with the plasmids of the original strain. This study highlights two points. It is the first report of co-expression of the blaNDM-5-IncX3 plasmid and mcr-1-IncHI2 plasmid in CRKP, and of the transfer of plasmids containing blaNDM-5 and mcr-1 genes via OMVs.
Real-Time Calibration of Disaggregated Traffic Demand
Authors: Pourmoradnasseri Mozhgan , Khoshkhah Kaveh , Hadachi Amnir 
Published: November 2022

Abstract
Real-time traffic demand estimation is essential for intelligent transportation systems and traffic forecasting in urban areas. Hence, this paper presents a simulation-based optimization framework for city-scale real-time estimation and calibration of dynamic demand models by focusing on disaggregated microsimulation in congested networks. The calibration approach is based on sequential optimization demand estimation for short time frames and uses a stream of traffic count data from IoT sensors on selected roads.
The proposed method builds upon the standard bi-level optimization formulation. The upper-level optimization problem is presented as a bounded variable quadratic programming in each time frame, making it computationally tractable. The DTA (dynamic traffic assignment) problem at the lower level is approached based on the stochastic route choice model.
For every time frame, the probabilistic parameters of the route choice model are obtained through several rounds of feedback loop between the OD optimization problem (at the upper level) and parallel samplings and simulations for DTA (at the lower level). At the end of each time frame, the microsimulation state of the network is transferred to the next time frame to ensure the temporal dependency and continuity of the estimations during the time. In addition, the algorithm's convergence is accelerated by applying the fixed-point method to road-segment travel times.

The proposed sequential calibration model presents a drastic computational advantage over available methods by splitting the computations into short time frames and under the assumption that the demand in each time frame only depends on current and previous time frames. The model does not depend on reliable prior demand information. Moreover, with receiving the field measurements as a stream and the efficient time complexity of the algorithm in each time frame, the method successfully presents a solution for high-dimensional real-time and online applications.
We validated the method with synthetic data and for a real-world case study in Tartu city, Estonia. The results show high accuracy under a tight computational budget.
Efficiency Dynamics and Productivity Analysis of Manufacturing Industries in Bangladesh
Authors: Sanusi Olajide , Adeeko Omotara 
Published: November 2022

Abstract

In this study we use the stochastic frontier model in estimating total factor productivity (TFP) growth and technical efficiencies for manufacturing industries in Bangladesh by using surveys collected during five rounds in 1982/83, 1984/85, 1988/89, 2005/06 and 2012. To detect the source of growth, we further decompose Total Factor Productivity growth into efficiency growth, scale component, and technological progress. Our result establishes that, on average, technical efficiency was 80%, noting that the export focused industries are comparatively more efficient than non-export focused industries. Furthermore, medium, and large-scale industries have a lower TFP growth than small scale industries. Furthermore, the Total Factor Productivity growth estimations shows that productivity in the manufacturing industries in Bangladesh was approximately 5.5% in the review period illustrating that technological progress is a major driver of growth. Additionally, this study provides evidence on the likelihood of TFP growth convergence over time among the manufacturing industries in Bangladesh.

JEL classification: D24; O14
Application of the SWAT model to assess climate and land use/cover change impacts on water balance components of the Kabul River Basin, Afghanistan
Authors: Ougahi Jamal Hassan , Karim Shahid , Mahmood Syed Amer 
Published: November 2022

Abstract
Hydrological models play a key role in simulating and assessing climate and land use/cover (LULC) change impacts on hydrology in a watershed. In this study, the impact of climate and LULC change was investigated using the Soil and Water Assessment Tool (SWAT) model. The simulated and observed streamflow showed a good agreement. Both Nash–Sutcliffe Efficiency (NSE) and coefficient of determination (R2) were found to be greater than 0.7 during the calibration (1985–2002) and validation (2003–2012) period. The water balance components were simulated with inputs from downscaled Global Climate Models (GCMs) data (i.e., future scenario (2030–2100) relative to a baseline period (1974–2004)) under RCP4.5 and RCP8.5, and hypothetical generated LULC change scenarios. All GCMs projected an increase in temperature over the Kabul River Basin (KRB), whereas there was a lack of agreement on projected precipitation among GCMs under both emission and future scenarios. Water yield (WYLD) and evapotranspiration (ET) were projected to decrease in the 21st century. Average annual WYLD was projected to increase under the agriculture-dominant scenario, whereas it decreased under forest and grassland-dominant scenarios. These results are valuable for relevant agencies and stakeholders to adopt measures to counter the negative impacts of climate and LULC change on water resources.
Crystallization and preliminary diffraction studies of a human fabµ with Anti-I activity
Authors: Polikarpov I. , Cauerhff A. , Mathov I. , Abatangelo C. , Plotkin L. , Goldbaum F.A. , Leoni J. 
Published: November 2022

Abstract:
An Fabµ from a human monoclonal cold agglutinin (KAU) was obtained by tryptic digestion and purified to homogeneity by FPLC. Crystals were grown by hanging drop vapour diffusion technique against mother liquor containing Sodium Hepes pH 7.5, and PEG 8000 as precipitant. Crystals were found to
belong to the trigonal space group P312l(P3221) with the cell parameters a=b=ll4.233 A, c=l72.787 A. The
crystals diffracted at least to 2_8 A resolution at a synchrotron beamline.
Selection of Peptide Ligands for A-1 Antitrypsin from a Phage Display Library
Authors: Fassina Giorgio , Palombo Giovanna , Dani Maria 
Published: November 2022

Abstract:
An eptapeptide phage library was used to isolate peptides interacting specifically with a-1 antitrypsin through a subtractive biopanning procedure. The peptide ligand identified after three selection cycles [SITPLVH] was chemically synthesized in a tetrameric form and analyzed for its capacity to recognize a-1 antitrypsin by ELISA assays. Multimeric ligand immobilization on solid supports for the preparation of a'°ffinity columns proved useful for the purification of a-1 antitrypsin in the presence of large amounts of albumin.