bluuebunny/crossref_metadata_2025_split huggingface dataset:
FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer
Authors: Long Yufei , Chong Tuotuo , Lyu Xiaoming , Chen Lujia , Luo Xiaomin , Faleti Oluwasijibomi Damola , Deng Simin , Wang Fei , He Mingliang , Qian Zhipeng , Zhao Hongli , Zhou Wenyan , Guo Xia , Chen Ceshi , Li Xin 
Published: October 2022

AbstractBackgroundEarly metastasis is a key factor contributing to poor breast cancer (BC) prognosis. Circulating tumor cells (CTCs) are regarded as the precursor cells of metastasis, which are ultimately responsible for the main cause of death in BC. However, to date molecular mechanisms underlying CTC formation in BC have been insufficiently defined.MethodsRNA-seq was carried out in primary tissues from early-stage BC patients (with CTCs≥5 and CTCs = 0, respectively) and the validation study was conducted in untreated 80 BC patients. Multiple in vitro and in vivo models were used in functional studies. Luciferase reporter, ChIP-seq, CUT&Tag-seq, and GST-pulldown, etc. were utilized in mechanistic studies. CTCs were counted by the CanPatrol™ CTC classification system or LiquidBiospy™ microfluidic chips. ERK1/2 inhibitor SCH772984 was applied to in vivo treatment.ResultsHighly expressed FOXD1 of primary BC tissues was observed to be significantly associated with increased CTCs in BC patients, particularly in early BC patients. Overexpressing FOXD1 enhanced the migration capability of BC cells, CTC formation and BC metastasis, via facilitating epithelial-mesenchymal transition of tumor cells. Mechanistically, FOXD1 was discovered to induce RalA expression by directly bound to RalA promotor. Then, RalA formed a complex with ANXA2 and Src, promoting the interaction between ANXA2 and Src, thus increasing the phosphorylation (Tyr23) of ANXA2. Inhibiting RalA-GTP form attenuated the interaction between ANXA2 and Src. This cascade culminated in the activation of ERK1/2 signal that enhanced metastatic ability of BC cells. In addition, in vivo treatment with SCH772984, a specific inhibitor of ERK1/2, was used to dramatically inhibit the CTC formation and BC metastasis.ConclusionHere, we report a FOXD1-dependent RalA-ANXA2-Src complex that promotes CTC formation via activating ERK1/2 signal in BC. FOXD1 may serve as a prognostic factor in evaluation of BC metastasis risks. This signaling cascade is druggable and effective for overcoming CTC formation from the early stages of BC.
Politicizing the future: on lithium exploration in Portugal
Authors: Araújo Emília , Bento Sofia , Silva Marcia 
Published: October 2022

AbstractThis text explores the meaning of the expression “mined future,” which has been used by local populations who oppose lithium production in Northern Portugal. We argue that the expression encapsulates the existence of a conflict for the “ownership” of future, unfolding a battle of visions of the future between local populations and governments. The local population sees the exploitation of lithium as a takeover of future. In contrast, the governments justify the project by promising a sociotechnical future in convergence with European green energy rhetoric. This article follows a grounded theory approach. It relies on information collected about the lithium exploration in Portugal, mainly through journalistic pieces and opinion articles disseminated between 2019 and 2020. In particular, the paper proposes that political action that involves large sociotechnical ventures with the potential of contamination needs to consider the local collective perceptions of the future.
A rare case of the scaphocephalic skull of an adult male
Authors: Ahmadpour Shahriar , Foghi Khadijeh 
Published: October 2022

Abstract
Background
Scaphocephaly is a craniofacial anomaly where the skull is disproportionately long and narrow. Premature closure of the sagittal suture is thought to be at the core of the etiopathology for scaphocephaly.

Case presentation
The skull is a well-preserved skull found in an antiquated graveyard at Parkand village Daregaz, Iran, with no visible signs of surgical manipulation. The craniofacial indices were measured. The maximum cranial length was 200 mm, and the measured length of nasion-bregma was 140mm, whereas most of the measurements were less than the normal scaphocephalic indices. Another morphological finding was the flattening of the frontal bone.

Conclusions
The cranial vault morphometry and morphology of the presented case fit the scalp. In addition to the characteristics of scaphocephaly, the presented skull was of a rare trait, frontal flattening, which has not been reported before.
Global seaweed farming and processing in the past 20 years
Authors: Zhang Lizhu , Liao Wei , Huang Yajun , Wen Yuxi , Chu Yaoyao , Zhao Chao 
Published: October 2022

AbstractSeaweed has emerged as one of the most promising resources due to its remarkable adaptability, short development period, and resource sustainability. It is an effective breakthrough to alleviate future resource crises. Algal resources have reached a high stage of growth in the past years due to the increased output and demand for seaweed worldwide. Several aspects global seaweed farming production and processing over the last 20 years are reviewed, such as the latest situation and approaches of seaweed farming. Research progress and production trend of various seaweed application are discussed. Besides, the challenges faced by seaweed farming and processing are also analyzed, and the related countermeasures are proposed, which can provide advice for seaweed farming and processing. The primary products, extraction and application, or waste utilization of seaweed would bring greater benefits with the continuous development and improvement of applications in various fields.
Graphical Abstract
Exploring the acceptability of a brief online theory-based intervention to prevent and reduce self-harm: a theoretically framed qualitative study
Authors: Keyworth Chris , Quinlivan Leah , Leather Jessica Z. , Armitage Christopher J. 
Published: October 2022

Background
The volitional help sheet for self-harm equips people with the means of responding automatically to triggers for self-harm with coping strategies. Improving acceptability may be crucial to increasing effectiveness and reach. The Theoretical Framework of Acceptability (TFA) was developed to guide the assessment of intervention acceptability, but to date, no studies have applied the TFA to understand acceptability of interventions for self-harm.

Aims
To apply the TFA to (a) explore people's experiences of a brief intervention to reduce repeat self-harm; and (b) understand the most prominent aspects of intervention acceptability, to make recommendations for intervention refinements and successful implementation.

Method
Sixteen semi-structured interviews were conducted with people who had previously self-harmed. The TFA informed a framework analysis in which findings were mapped onto the TFA.

Results
Four TFA domains were identified that were associated with acceptability of the volitional help sheet for self-harm: affective attitude, burden, intervention coherence and perceived effectiveness. People were generally positive about using the volitional help sheet (affective attitude), understood the volitional help sheet and how it worked (intervention coherence), highlighted engagement as a motivating factor in using the volitional help sheet (perceived burden) and described how the volitional help sheet could be implemented by healthcare professionals (perceived effectiveness).

Conclusions
Further modifications could still be made, but it is hoped that this intervention provides a useful tool for individuals to construct their own personalised implementation intentions, and as part of longer-term support for preventing self-harm as delivered by healthcare professionals.
Transforming access to care for serious mental disorders in slums (the TRANSFORM Project): rationale, design and protocol
Authors: Singh Swaran P. , Jilka Sagar , Abdulmalik Jibril , Bouliotis Georgios , Chadda Rakesh , Egbokhare Olayinka , Huque Rumana , Hundt Gillian Lewando , Iyer Srividya , Jegede Obafemi , Khera Neeru , Lilford Richard , Madan Jason , Omigbodun Akinyinka , Omigbodun Olayinka , Raja Tasneem , Read Ursula M. , Siddiqi Bulbul Ashraf , Sood Mamta , Soron Tanjir Rashid , Ahmed Helal Uddin 
Published: October 2022

Summary
This paper introduces the TRANSFORM project, which aims to improve access to mental health services for people with serious and enduring mental disorders (SMDs – psychotic disorders and severe mood disorders, often with co-occurring substance misuse) living in urban slums in Dhaka (Bangladesh) and Ibadan (Nigeria). People living in slum communities have high rates of SMDs, limited access to mental health services and conditions of chronic hardship. Help is commonly sought from faith-based and traditional healers, but people with SMDs require medical treatment, support and follow-up. This multicentre, international mental health mixed-methods research project will (a) conduct community-based ethnographic assessment using participatory methods to explore community understandings of SMDs and help-seeking; (b) explore the role of traditional and faith-based healing for SMDs, from the perspectives of people with SMDs, caregivers, community members, healers, community health workers (CHWs) and health professionals; (c) co-design, with CHWs and healers, training packages for screening, early detection and referral to mental health services; and (d) implement and evaluate the training packages for clinical and cost-effectiveness in improving access to treatment for those with SMDs. TRANSFORM will develop and test a sustainable intervention that can be integrated into existing clinical care and inform priorities for healthcare providers and policy makers.
Assessing the relationship between maternal risk for attention deficit hyperactivity disorder and functional connectivity in their biological toddlers
Authors: Kerr-German Anastasia , White Stuart F. , Santosa Hendrik , Buss Aaron T. , Doucet Gaelle E. 
Published: October 2022

Abstract

Background
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder associated with increased risk for poor educational attainment and compromised social integration. Currently, clinical diagnosis rarely occurs before school-age, despite behavioral signs of ADHD in very early childhood. There is no known brain biomarker for ADHD risk in children ages 2–3 years-old.

Methods
The current study aimed to investigate the functional connectivity (FC) associated with ADHD risk in 70 children aged 2.5 and 3.5 years via functional near-infrared spectroscopy (fNIRS) in bilateral frontal and parietal cortices; regions involved in attentional and goal-directed cognition. Children were instructed to passively watch videos for approximately 5 min. Risk for ADHD in each child was assessed via maternal symptoms of ADHD, and brain data was evaluated for FC.

Results
Higher risk for maternal ADHD was associated with lower FC in a left-sided parieto-frontal network. Further, the interaction between sex and risk for ADHD was significant, where FC reduction in a widespread bilateral parieto-frontal network was associated with higher risk in male, but not female, participants.

Conclusions
These findings suggest functional organization differences in the parietal–frontal network in toddlers at risk for ADHD; potentially advancing the understanding of the neural mechanisms underlying the development of ADHD.
Risk Modeling to Reduce Monitoring of an Autoantibody-Positive Population to Prevent DKA at Type 1 Diabetes Diagnosis
Authors: O’Rourke Colin , Ylescupidez Alyssa , Bahnson Henry T , Bender Christine , Speake Cate , Lord Sandra , Greenbaum Carla J 
Published: October 2022

Abstract

Context
The presence of islet autoimmunity identifies individuals likely to progress to clinical type 1 diabetes (T1D). In clinical research studies, autoantibody screening followed by regular metabolic monitoring every 6 months reduces incidence of diabetic ketoacidosis (DKA) at diagnosis.

Objective
We hypothesized that DKA reduction can be achieved on a population basis with a reduced frequency of metabolic monitoring visits. We reasoned that prolonged time between the development of T1D and the time of clinical diagnosis (“undiagnosed time”) would more commonly result in DKA and thus that limiting undiagnosed time would decrease DKA.

Methods
An analysis was conducted of data from TrialNet's Pathway to Prevention (PTP), a cross-sectional longitudinal study that identifies and follows at-risk relatives of people with T1D. PTP is a population-based study enrolling across multiple countries. A total of 6193 autoantibody (AAB)-positive individuals participated in PTP from March 2004 to April 2019. We developed models of progression to clinical diagnosis for pediatric and adult populations with single or multiple AAB, and summarized results using estimated hazard rate. An optimal monitoring visit schedule was determined for each model to achieve a minimum average level of undiagnosed time for each population.

Results
Halving the number of monitoring visits usually conducted in research studies is likely to substantially lower the population incidence of DKA at diagnosis of T1D.

Conclusion
Our study has clinical implications for the metabolic monitoring of at-risk individuals. Fewer monitoring visits would reduce the clinical burden, suggesting a path toward transitioning monitoring beyond the research setting.
Classic and Follicular Variant of Papillary Thyroid Microcarcinoma: 2 Different Phenotypes Beyond Tumor Size
Authors: Sparano Clotilde , Rotondi Mario , Verdiani Valentina , Brunori Paolo , Castiglione Francesca , Bartoli Caterina , Perigli Giuliano , Badii Benedetta , Vezzosi Vania , Simontacchi Gabriele , Livi Lorenzo , Antonuzzo Lorenzo , Maggi Mario , Petrone Luisa 
Published: October 2022

Abstract

Context
Despite the wide revision of current guidelines, the management of papillary thyroid microcarcinoma (mPTC) still has to be decided case by case. There is conflicting evidence about the role of more frequent histological subtypes, and no data about potential differences at presentation.

Objective
Our aim was to compare the phenotype of the 2 most frequent mPTC variants, namely, classical papillary thyroid microcarcinoma (mPTCc) and the follicular variant of papillary thyroid microcarcinoma (mFVPTC) .

Methods
Retrospective observational study, from January 2008 to December 2017 of a consecutive series of patients with mPTCc and mFVPTC. All cases were classified according to the 2015 American Thyroid Association (ATA) risk classification. Clinical and preclinical features of mPTCc and mFVPTC at diagnosis were collected. The comparison was also performed according to the incidental/nonincidental diagnosis and differences were verified by binary logistic analysis.

Results
In total, 235 patients were eligible for the analysis (125 and 110 mPTCc and mFVPTC, respectively). Compared with mPTCc, mFVPTCs were more often incidental and significantly smaller (4 vs 7 mm) (P &lt; .001 all), possibly influenced by the higher rate of incidental detection. mFVPTC and incidental (P &lt; .001 both) tumors were significantly more often allocated within the low-risk class. A logistic regression model, with ATA risk class as the dependent variable, showed that both mFVPTC (OR 0.465 [0.235-0.922]; P = .028]) and incidental diagnosis (OR 0.074 [0.036-0.163]; P &lt; .001) independently predicted ATA risk stratification.

Conclusion
mFVPTC shows some differences in diagnostic presentation compared with mPTCc, and seems to retain a significant number of favorable features, including a prevalent onset as incidental diagnosis.
Prone Transpsoas Lateral Lumbar Interbody Fusion for Degenerative Lumbar Spine Disease: Case Series With an Operative Video Using Fluoroscopy-Based Instrument Tracking Guidance
Authors: Soliman Mohamed A. R. , Ruggiero Nicco , Aguirre Alexander O. , Kuo Cathleen C. , Khawar Wasiq I. , Khan Asham , Jowdy Patrick K. , Starling Robert V. , Mullin Jeffrey P. , Pollina John 
Published: October 2022

BACKGROUND:
Lateral lumbar interbody fusion has inherent limitations, such as the necessity to reposition the patient. To overcome this limitation, the prone transpsoas (PTP) approach for lateral lumbar interbody fusion has been developed.

OBJECTIVE:
To report clinical and radiographic outcome measures of a series of patients who underwent PTP at our hospital.

METHODS:
A retrospective chart review was conducted to identify patients who underwent PTP for degenerative lumbar spine disease between September 2019 and August 2021. A thorough analysis of clinical and radiographic outcome measures for these patients was conducted.

RESULTS:
Our search resulted in the identification of 15 consecutive patients. Four patients were operated using the assistance of fluoroscopy-based instrument tracking. Overall, the mean follow-up duration was 11.9 ± 7.9 months. Radiographically, the PTP approach resulted in significant postoperative improvement of lumbar lordosis (P = .03) and pelvic incidence minus lumbar lordosis (P < .005). No significant difference was found postoperatively in other regional sagittal alignment parameters, including pelvic tilt, sacral slope, or pelvic incidence. Clinically, the patients' Oswestry Disability Indices (P = .002) and Short Form Survey-12 Physical Scores improved significantly (P = .01). The estimated mean blood loss for patients who underwent the PTP procedure was 137.7 ± 96.4 mL, the mean operative time was 212.5 ± 77.1 minutes, and the mean hospital stay was 2.7 ± 1.4 days. One patient each had superficial wound infection, transient paralytic ileus, transient pulmonary embolism, transient urinary retention, or required revision lumbar surgery.

CONCLUSION:
This study demonstrates that the PTP approach is associated with significant improvement in radiographic and clinical outcomes.
Percutaneous Balloon Compression for Treatment of Trigeminal Neuralgia Assisted by O-Arm O2-Based Navigation: Case Series and Review of the Literature
Authors: D'Ercole Manuela , Izzo Alessandro , Silvestri Martina , Olivi Alessandro , Tufo Tommaso 
Published: October 2022

BACKGROUND:
Percutaneous cannulation of foramen ovale (FO) for treatment of trigeminal neuralgia, classically performed according to empirical landmarks and under fluoroscopic guide, may be difficult, time-consuming, and burdened with vascular or neurological complications related to close anatomic relationships.

OBJECTIVE:
To investigate cannulation of FO for treatment of trigeminal neuralgia assisted by O-Arm O2-based navigation, to assess safety and accuracy.

METHODS:
Nineteen patients underwent percutaneous balloon compression of Gasserian ganglion assisted by navigation provided by O-Arm O2 and StealthStation. Clinical outcomes according to Barrow Neurological Institute Pain Score, time of recurrence, side effects, and complications, as well as technical aspects as time of the procedure and number of tracks were investigated and evaluated. Obtained data were compared with current literature in a systematic review.

RESULTS:
The median time for procedure was 46 minutes; cannulation of the FO was performed in a median of 3 minutes and 47 seconds, in a single track in 16 patients, while 3 cases required a further O-Arm acquisition to check the needle position. No complications were observed. Onset of facial hypoesthesia was recorded in 10 patients and dysesthesia in 5. Although at a median follow-up of 12.7 months 7 patients had recurrence after an average pain-free period of 7.3 months, all but 2 patients had improvement in pain score.

CONCLUSION:
Advantages powered by navigation should be addressed in accuracy, lower complication rate, and success of cannulation even in case of previous treatments or anatomic variations, rather than in effective reduction of surgical time.
How the Individual's Choice of Coping Behavior Strategy is Influenced by the Agentic Activity Type
Authors: Ryabikina Z. , Petros'yan S. , Gubanova N. 
Published: October 2022

With reference to the ideas of the dialogic (M. Buber), structural-dynamic (B.D. Parygin) and subjective-existentialistic (Z.I. Ryabikina) concepts, basing the research methodology on the principles of synergetics, we have developed the agentic-dynamic approach to personality studies, where emphasis is made on the role of personality positioning systems in the agency development processes.
The development of the personality positioning systems self-organization follows four vector lines: Infantile, Aggressive, Sabotaging, Mighty. We have proposed to use the term “agentic activity type” for such ways of personality positioning self-organization, since these systems predetermine the typical nature and direction of the agent’s activity.
The study became possible by virtue of the development of the Model of the Dispositional Structure of Agentic Activity and creation of the Personality’s Agentic Activity Profile inventory based on this model. The inventory tests the agentic activity profile as an individual dynamic system formation. The factorization of the data allows to identify sets of personality positions as pervasive organizing principles, or types. As system formations, the agentic activity types should be manifested in various personality characteristics, including the characteristics of coping behavior.
The article presents the results of an empirical study of the correlation between the agentic activity types identified via factorization of the data obtained using the author's “Personality’s Agentic Activity (PAA) Profile” inventory and the scales of Lazarus’s WCQ (Ways of Coping Questionnaire). Regression models have been built, allowing to predict the coping behavior of an individual both specifically, that is, for selected personality positions, and globally, for an agentic activity type. It has been shown that the Infantile, Aggressive and Sabotaging types tend to choose coping strategies within an instinctive-protective paradigm: escape-avoidance, confrontation, distancing. The mighty type tends to use rational coping strategies aimed at practical resolution of the conflict and transformation of the situation, i.e. positive reassessment and decision planning. Notice has been given to similarity of the holistic styles of coping behavior of the Infantile, Aggressive and Sabotaging types with the styles of coping with basal anxiety according to K. Horney.
The obtained results allow to consider the personality positioning systems of an agent as a source that forms “mature” or “immature” coping behavior.
On the problem of using information and communication technologies in the aesthetic education of students
Authors: Rabadanova R. , Artemyeva S. , Kotovchihina N. 
Published: October 2022

The article deals with the problem of aesthetic education of the younger generation. The authors present an analysis of the psychological and pedagogical literature of domestic and foreign scientists dealing with the issues of aesthetic education of children. The organization of the educational process of primary school students and the development of their aesthetic worldview in modern socio-cultural conditions is impossible without the use of information and communication technologies (ICT).
The article describes in detail the process of the formative stage of the experiment of aesthetic education of primary school students in the conditions of a pandemic and acceleration of the process of transformation of the educational system using digital technologies. The possibility of effective use of information and communication technologies for conducting extracurricular educational activities in the process of forming an aesthetic intelligence of younger schoolchildren is substantiated.
As an effective means of ICT to solve the stated problem, the article identifies a virtual tour. In this study, the authors consider the classification of virtual excursions, the features of the use of some of its varieties in the educational process during distance learning.