bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Safety of Systemic Janus Kinase Inhibitors in Atopic Dermatitis: a Systematic Review and Network Meta-analysis
Authors: Alves Carlos , Penedones Ana , Mendes Diogo , Marques Francisco Batel 
Published: July 2022

Abstract
Purpose
Janus kinase (JAK) inhibitors have been developed to treat moderate to severe atopic dermatitis, but there is little evidence comparing the safety profile of these drugs. The aim of this study is to compare the relative safety of the different systemic JAK inhibitors in atopic dermatitis.
Methods
Medline, EMBASE and clinicaltrials.gov were searched to identify phase 2/3, clinical trials (RCTs) designed to evaluate the efficacy and safety of systemic JAK inhibitors in atopic dermatitis. Outcomes were the risk of any adverse event (AE), serious AEs, AEs leading to treatment discontinuation, any infection, serious infections, herpes viral infections and any cardiac or vascular event.
Results
Eighteen RCTs were included. Compared with placebo, baricitinib (Odds Ratio [OR] 1.25, 95% credible interval [CrI] 1,03–1.55), abrocitinib (OR 1.54, 95% CrI 1,25–1.90), and upadacitinib (OR 1.46, 95% CrI 1,19–1.81) increase the risk of any adverse event. Abrocitinib (OR 1.62, 95% CrI 1.7–2.72), upadacitinib (OR 1.67, 95% CrI 1.19–2.43), and dupilumab (OR 1.69, 95% CrI 1.02–2.79) increase the risk of infections when compared with placebo. The risk of herpes viral infections is increased with abrocitinib (OR 4.88; 95% CrI 1.79–16.91) and upadacitinib (OR 3.66; 95% CrI 1.61–11.13) compared to placebo. No further statistically significant risk differences between treatments were identified.
Conclusions
The results suggest systemic JAK inhibitors for atopic dermatitis have a similar safety profile. However, as current data present limitations, postmarketing safety evidence will be crucial to draw definitive conclusions regarding the safety of JAK inhibitors.
JNK signaling activity in pioneer neurons modulates the architectural organization of the CNS of Drosophila embryos
Authors: Karkali Katerina , Saunders Timothy , Panayotou George , Martin-Blanco Enrique 
Published: July 2022

Abstract
Morphogenesis of the Central Nervous System (CNS) is a complex process that obeys precise architectural rules. Yet, the mechanisms dictating these rules remain unknown. Analyzing morphogenesis of the Drosophila embryo Ventral Nerve Cord (VNC), we found that a tight control of JNK signaling is essential to attain the final VNC architecture. JNK signaling in a specific subset of pioneer neurons autonomously regulates the expression of Fasciclin 2 (Fas 2) and Neurexin IV (Nrx IV) adhesion molecules via the transcription factor zfh1. Interfering at any step in this cascade affects the fasciculation of axons and the dendritic make up of primary neurons. This leads to secondary cumulative scaffolding defects during the structural organization of the axonal network, revealed in aberrant spatial correlations along the Antero-Posterior (AP) axis of the VNC. The global loss of architectural robustness and tensional balance ultimately influences nervous system condensation. In summary, our data point to the JNK cascade in a subset of pioneer neurons as a key element underpinning VNC architecture, revealing critical milestones on the mechanism of control of its structural organization
Long-term survive of Aliarcobacter butzleri in two models symbiotic interaction with Acanthamoeba castellanii
Authors: Medina Gustavo A. , Flores-Martin Sandra N. , Pereira Wellison A. , Figueroa Elías G. , Guzmán Neftalí H. , Letelier Pablo J. , Andaur Marcela R. , Leyán Pilar I. , Boguen Rodrigo E. , Fernández Heriberto 
Published: July 2022

Abstract
Aliarcobacter butzleri (formerly known as Arcobacter butzleri) is an emerging foodborne zoonotic pathogen that establishes in vitro endosymbiotic relationships with Acanthamoeba castellanii, a free-living amoeba. Previously, we described that this bacterium acts as an endocytobiont of A. castellanii, surviving for at least 10 days in absence of bacterial replication. Thus, the aim of this study was to evaluate the ability of A. butzleri to survive as a long-term endosymbiont of A. castellanii for 30 days in two models of symbiotic interaction with A. castellanii: i) endosymbiotic culture followed by gentamicin protection assay and ii) transwell co-culture assay. The results allow us to conclude that A. butzleri is capable of surviving as an endosymbiont of A. castellanii for at least 30 days, without multiplying, under controlled laboratory conditions. In addition, in the absence of nutrients and as both microorganisms remain in the same culture, separated by semi-permeable membranes, A. castellanii does not promote the survival of A. butzleri, nor does it multiply. Our findings suggest that the greater survival capacity of A. butzleri is associated with their endosymbiont status inside A. castellanii, pointing out the complexity of this type of symbiotic relationship.
Incremental diagnostic value of perivascular fat attenuation index for identifying hemodynamically significant ischemia with severe calcification
Authors: Shan Dongkai , Ding Yipu , Wang Xi , Liu Zinuan , Dou Guanhua , Wang Kai , Zhang Wei , Jing Jing , He Bai , Li Yang , Yang Junjie , Chen Yundai 
Published: July 2022

Abstract
Purpose
To explore the incremental value of perivascular fat attenuation index (FAI) to identify hemodynamically significant ischemia in severe calcified vessels.
Methods
Patients who underwent coronary computed tomographic angiography (CCTA) examination at Chinese PLA General Hospital from 2017 to 2020 and subsequently underwent fractional flow reserve (FFR) examination within 1 month were consecutively included. Several CCTA-derived indices were measured, including the coronary artery calcification score (CACS), lesion length, ≥CAD-RADS 4 proportion, perivascular FAI and CT-FFR. The included vessels were divided into a nonsevere calcification group and a severe calcification group according to the quartile of CACS. FFR ≤ 0.80 represents the presence of hemodynamically significant ischemia.
Results
A total of 124 patients with 152 vessels were included (age: 61.1 ± 9.2 years; male 64.5%). Significant differences in lesion length (28.4 ± 14.2 vs. 23.1 ± 12.3 mm, P = 0.021), perivascular FAI (-73.0 ± 7.5 vs. -79.0 ± 7.4 HU, P < 0.001) and CT-FFR (0.78 ± 0.06 vs. 0.86 ± 0.04, P < 0.001) were noted between the FFR ≤ 0.80 group (47 vessels) and the FFR > 0.80 group (105 vessels). Furthermore, the perivascular FAI in the FFR ≤ 0.80 group was significantly greater than that in the FFR > 0.80 group (nonsevere calcification: -73.2 ± 7.5 vs. -78.2 ± 7.4 HU, P = 0.002; severe calcification: -72.8 ± 7.7 vs. -82.7 ± 6.3 HU, P < 0.001). In discriminating hemodynamically significant ischemia, the specificity and accuracy of CT-FFR were significantly affected by severe calcification, which demonstrated a significantly declining trend (P = 0.033 and P = 0.010, respectively). The diagnostic performance of CT-FFR in the severe calcification group was lower than that in the nonsevere calcified group. However, perivascular FAI showed good discriminative performance in the severe calcification group. In combination with perivascular FAI, the predictive value of CT-FFR in identifying hemodynamically significant ischemia with severe calcification increased from an AUC of 0.740 to 0.919.
Conclusion
For coronary artery with severe calcification, the diagnostic performance of CT-FFR in discriminating flow-limiting lesions could be greatly impaired. Perivascular FAI represents a potential reliable imaging marker to provide incremental diagnostic value over CT-FFR for identifying hemodynamically significant ischemia with severe calcification.
The potential of soluble programmed death-ligand 1 (sPD-L1) as a diagnosis marker for colorectal cancer
Authors: Shao Weifang , Xu Yanhua , Lin Suzhen , Gao Junli , Gao Junshun , Wang Hong 
Published: July 2022

Abstract
Colorectal cancer (CRC) is one of the most significant neoplasms with high morbidity and mortality. Activation of the programmed death protein 1/programmed death ligand 1 (PD-1/PD-L1) signaling pathway results in tumor immune evasion by suppressing the activity of T cells. The correlation of soluble PD-L1 (sPD-L1) in serum/plasma with clinicopathological features, lymph node metastasis, diagnosis and prognosis is less clear. The aim of this study was to investigate the relationship between sPD-L1 and diagnosis potential and clinicopathological features and prognosis of CRC patients. Three hundred patients with CRC were included in this study. sPD-L1 was measured by ELISA. Pretreatment levels of sPD-L1 were significantly elevated in CRC patient sera compared to healthy donors (P < 0.001). The median value of sPD-L1 in healthy donors, CRC with non-lymph node metastasis, and CRC with lymph node metastasis were 246.78 ± 50.2pg/mL, 284.12 ± 52.7pg/mL, and 321.31 ± 55.3pg/mL, respectively. ROC analysis of sPD-L1 allowed significant differentiation between HC group and CRC group (lymph node metastasis and non lymph node metastasis (AUC = 0.861, 95% CI 0.830–0.887, p < 0.001). sPD-L1 is a potential biomarker for the diagnosis of CRC. Multivariate analysis showed that lymph node metastasis and tumor differentiation were independent prognostic factors (all P < 0.01), and sPD-L1 was not correlated with the CRC prognosis (p > 0.05).
Challenges and strategies in high-accuracy manufacture of the world's largest SiC aspheric mirror
Authors: Zhang Xuejun 
Published: July 2022

Abstract
In consideration of the difficulties in the high-accuracy manufacture of the world's largest aperture SiC (silicon carbide) aspheric mirror, such as the difficulty of processing complex mirror blanks, low accuracy and efficiency of conventional processing, print-through effect, inconsistent processing and testing states, high stress/poor denseness of conventional cladding, the insufficient dynamic range of conventional measurement, and air turbulence of long optical path testing, we proposed the water-soluble room temperature vanishing mold and gel casting technology, homogeneous microstructure reaction-formed joint technology, nano-accuracy efficient convergence processing technology, gravity unloading technology, high-denseness low-defect PVD (Physical Vapor Deposition) cladding process, data fusion testing technology, time-domain averaging method, etc. On the basis of the proposed key technologies and methods, we have currently developed the world's largest SiC aspheric mirror with the size of ⌀4.03m. The impressive performance of the SiC aspheric mirror is verified as follows. The area density of the SiC blank is less than 120kg/m2; surface error testing accuracy is less than 6nm RMS; the thickness inhomogeneity of cladding layer is less than 5%; the final surface error and roughness are 15.2nm RMS and 0.78nm RMS, respectively.
Predicting bending strength of concrete using a novel-structured multivariable grey model with various orders
Authors: Bo Zeng , Yin fengfeng , Liu Sifeng , Yang yingjie , Yu Lean 
Published: July 2022

Abstract
Bending strength of concrete is one of the significant indexes to measure the mechanical properties of concrete. A reliable prediction about the bending strength of concrete is of great importance to maintain the health state and service life of concrete. However, it is difficult to obtain reliable data of large samples due to the high cost, serious destructiveness and complex influencing factors of concrete bending strength test data collection. In view of this, based on the multivariable grey prediction model whose modeling object is small data, we construct a new novel-structured multivariable grey prediction model VGM(1,N,ri) with various orders for predicting the bending strength of concrete. It defines and optimizes the accumulative orders differentially and introduces a nonlinear correction term to expand the model structure. Then, the bending strength of concrete is modeled using the new model, and its comprehensive error is only 0.035%, which is much smaller than the conventional NSGM(1,N) and FMGM(1,N) models (5.232% and 2.624%, respectively). The findings provide a new modeling method for the prediction of concrete bending strength in areas with large temperature difference, and have significance for enriching and improving the methodologies of grey prediction models.
A study exploring the effects of cell disruption techniques on lipid recovery in co-cultivated microalgae and oleaginous yeast
Authors: Jayakumar Tharunkumar , rakesh suchitra 
Published: July 2022

Abstract
Co-cultivated microalgae and oleaginous yeast are promising in improving lipid and biomass yield, resulting in cheaper biofuel production with several economic prospects. This study evaluated three microalgal and three oleaginous yeast combinations to study biomass, and lipid production as well as the differences in the yield while using distinct cell disruption approaches, viz., sonication, microwave, freezing, osmotic shock, and autoclave. Among the different cell disruption strategies used, sonication was found to be the most effective, resulting in the highest lipid yield by the co-cultivation of S. obliquus with Y. lipolytica, C. sorokiniana with R. glutinis, and C. protothecoides with Y. lipolytica obtaining 49.4%, 50.7% and 53.6% of lipid content respectively. Compared to the monocultures, various microalgae and oleaginous yeast combinations reported higher biomass and lipid yield. FAME (Fatty acid methyl esters) analysis by Gas chromatography of the three combinations reported the presence of biofuel precursors like palmitic acid, linoleic acid, oleic acid, and heptadecanoic acid, which confirms their suitability for biofuel production. The results demonstrated that co-cultivated microalgae and yeast, assisted with an effective cell disruption technique, can enhance lipid yield and be applied for biofuel production.
Diagnostic and prognostic value of PD-L1 in patients with colorectal cancer
Authors: Shao Weifang , Xu Yanhua , Lin Suzhen , Gao Junshun , Gao Junli , Wang Hong 
Published: July 2022

Abstract
Colorectal carcinoma (CRC) is one of the most frequently encountered neoplasms with high morbidity and mortality. Activation of the programmed death protein 1/programmed death ligand 1 (PD-1/PD-L1) signaling pathway results in tumor immune evasion by suppressing the activity of T cells. The correlation of PD-L1 with clinicopathological features, lymph node metastasis, diagnosis and prognosis is less clear in CRC. The aim of present work was to investigate the diagnostic and prognostic value of PD-L1, and the association of PD-L1 with clinicopathological features in CRC patients. Three hundred and eighty-six patients were included in this study. The soluble PD-L1 (sPD-L1) in Serum was measured by ELISA, and PD-L1 on tumor cells was evaluated by immunohistochemistry. Pretreatment levels of sPD-L1 were significantly elevated in CRC patient sera compared to healthy donors (P < 0.001). ROC analysis of sPD-L1 allowed significant differentiation between HC group and CRC group (lymph node metastasis and non lymph node metastasis (AUC = 0.800, 95% CI 0.756–0.838, p < 0.001), and indicated that sPD-L1 is a potential diagnosis biomarker of CRC. The Cox proportional hazards regression analysis showed that the tumor sizes, sPD-L1 levels and clinicopathologic stages were not correlated with the CRC prognosis (all p > 0.05). Meanwhile, univariate analysis indicated that the PD-L1 expression on tumor cells, tumor differentiation, and lymph node metastasis were statistically associated with the prognosis of CRC patient (all p < 0.05). The multivariate analysis further demonstrated that the PD-L1 expression on tumor cells and lymph node metastasis were two independent prognostic factors of CRC (all p < 0.05). Our study demonstrates that sPD-L1 is a potential diagnosis biomarker, and PD-L1 expression on tumor cells and lymph node metastasis are independent prognostic factors in CRC patients.
Stationary equilibria of N-player stochastic games
Authors: Oliu-Barton Miquel , Attia Luc 
Published: July 2022

Abstract
We provide a characterisation of the set of stationary equilibria for finite discountedstochastic games using an approach inspired by Atkinson (Academic Press, 1972). In the zero-sum case, this approach has already led to a characterisation of the discounted values and of the limit value (Attia and Oliu-Barton, Proceedings of the National Academy of Sciences, 2019), and to efficient algorithms to compute these quantities (Oliu-Barton, Mathematics of Operations Research, 2021). The extension of these results to the non-zero sum case, that is an efficient computation of stationary equilibria, and a characterisation of the limit set of stationary equilibrium payoffs, which is known to exist (Renault and Ziliotto, Mathematics of Operations Research, 2020), are two very hard open problems, which could be tackled using our characterisation. Interestingly, this characterisation remains valid for a broader class of games, the so-called normal-form games with complementarities, which models the static interaction of several firms on finitely many complementary markets.
Laparoscopic inguinal hernia repair in the obese patient population: A single- center’s 5- year experience
Authors: Pararas Nikolaos , Pikouli Anastasia , Bounnah Messaoud , Zenah Yousef , Alkadrou Abdulkarim Muoustafa , Papakonstantinou Dimitris , Pikoulis Emmanouil 
Published: July 2022

Abstract
Purpose: The purpose of the present study is to explore how obesity impacts daily practice by reviewing the experience of a single-center, to evaluate the distribution of the TAPP and TEP methods amongst obese and non-obese patient populations and assess relevant postoperative outcomes.Methods: patients undergoing elective minimally invasive inguinal hernia repair in our hospital, were included from January 2017 to January 2022. Data of interest were the minimally invasive technique utilized, patient demographics, individual patient American Society of Anesthesiology (ASA) score, the body mass index (BMI), underlying hypertension and diabetes, and smoking status.Results: A total of 109 patients were included in the present analysis, of which 81 (74.3%) underwent elective TEP repairs, while 28 (25.7%) underwent elective TAPP repairs. Overall, 39 (35.7%) patients were included in the obesity subgroup with an average BMI of 35.4 ± 4.9, with a range from 30,1 to 52,7, and 70 (64.3%) were included in the non-obese subgroup, with an average BMI of 23.2 ± 3.3 and a range from 16,2 to 29,7.Conclusions: The laparoscopic approach to inguinal hernia repair in obese patients has similar outcomes as an open approach regarding the 30-day events, in the hands of experienced surgeons with the advantages of the laparoscopic approach vs. the open one.
Existence and stability of solutions for linear and nonlinear damping of q−fractional Duffing-Rayleigh problem
Authors: Houas Mohamed , Samei Mohammad Esmael 
Published: July 2022

Abstract
In this current paper, by using q−fractional calculus, we study the Duffing-Rayleigh type problem with sequential fractional q−derivative of the Caputo type. We investigate the existence and uniqueness of solutions by applying some classical fixed pointtheorems. Also we define and study the Ulam-Hyers and the Ulam-Hyers-Rassias stabilities of solutions for our problem. An example is presented to illustrate the main results.(2010) Mathematics Subject Classifications: 26A33, 39B72, 34C45.
Cochlear affection in obese children
Authors: Gomaa Mohammed A. , Abdelaal Omnia , Moniem Rasha A. Abdel , kader Rafeek M. Abdel 
Published: July 2022

Abstract
Objective:-Overweight and obesity are defined as abnormal or excessive fat accumulation that may impair health. Obesity can influence the whole body, including Ear, owing to mega inflammation.The primary target of this research is to detect minor changes in the hearing of obese children by Otoacoustic Emission (OAE) and High Frequency Audiometry (HFA). Patients and Method:-The current study is prospective that done at otorhinolaryngology clinic of Minia University Hospital, the study sample was divided into two subgroups, their age range from 6 to 17 years. The control group consisted of 20 children with average weight, while the experimental group consisted of 58 obese children. Both groups had no history of systemic or immunological diseases that affect their hearing. There were no history of hearing loss, delayed speech and language development or consanguinity . Both groups were subjected to Measurement of transient evoked otoacoustic emission, Distortion Product Otoacoustic Emission (OAE), and High-Frequency Audiometry (HFA)Results:-As regard of the audiological evaluation, there is no statistically significant difference between the two groups in the Pure Tone Audiometry (PTA) in all frequencies (from 0.25 to 8). HFA revealed a statistically significant difference (P < 0.05) between the two groups in 20000 HZ frequency.Transient OAE shows a statistically significant difference (P < 0.001) between both groups, while DPOAE shows no statistically significant difference between both groups as all ears were normal in the response.Conclusion:- Obesity is not a simple disease, but it impairs the high-frequency portion of the cochlea, early detection of any subtle affection of the cochlea must be detected, and screening of obese children is mandatory even if there is no complaint of hearing diminution.
Covid-19 has turned things upside down: e-learning in Bukavu city in the Democratic Republic of the Congo
Authors: M Isidore Murhi , N. Daina Salama , N. Dieudonné Kahasha 
Published: July 2022

Abstract
In the Democratic Republic of Congo (DRC), e-learning is a new concept for academic institutions. Covid-19 has reignited the debate about using Information and Communication Technology (ICT) within institutions. Technology is evolving exponentially, and Information and Communication Technology-based is now essential in all sectors. During the lockdown, due to the Covid-19 pandemic, which led to the educational institution's closure, e-learning became the rule, and face-to-face (in-person) teaching was the exception. Based on qualitative data on information and communication technology use with non-structured interviews in higher institutions in Bukavu, this paper attempts to understand the obstacles to the transition from face-to-face teaching to e-learning during the Covid-19 period. Our results show that many educational institutions lack information and communication technology tools and infrastructures. The Covid-19 pandemic advent brought most educational institutions to stop activities.