bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cryptogenic stroke in atrial fibrillation without intra-heart thrombi: possible mechanisms
Authors: Germanova O. A. , Germanov A. V. , Galati G. , Prokhorenko I. O. , Germanov V. A. 
Published: April 2022

Background. Up to 45% of ischemic strokes are cryprogenic.Aim is to study which variant of permanent AF without intra-heart thrombi is the most unfavorable in appearing of stroke.Methods. We observed 202 patients with permanent AF without intra-heart thrombi and hemodynamically not significant carotid bifurcation atherosclerotic stenosis. We performed echocardiography, 24-hours monitoring of electrocardiography (ECG), ultrasound of brachiocephalic arteries, sphygmography of common carotid arteries, computer tomography of the brain, hemostasiograms, lipid profile, hemoglobin A1c. According to the 24-hours ECG monitoring data, we divided patients into two groups up to the maximum pauses between ventricular complexes in AF: patients with a pause <1,5 seconds (113); ≥1,5 seconds (89). Both groups were on the same standard therapy including novel oral anticoagulants. We observed the patients during 1 year to analyze the verified stroke or transient ischemic attack (TIA).Results. In ultrasound, there was an increase of linear blood flow velocity in the area of carotid stenosis during the spread of the pulse wave after the long pause between ventricular contractions in group 2 up to 2,5 m/sec as in hemodynamically significant stenosis. In 1-year observation, there was the higher stroke in group 2.Conclusion. The appearance of stroke and TIA in AF is higher in patients who have 1,5 seconds and more of maximum duration pauses between ventricular contractions. The reason of cryptogenic stroke can be the atherosclerotic plaque defragmentation with further embolism, caused by additional mechanical impact of increased hemodynamical parameters of pulse wave after long pause between ventricular contractions.
HERMENEUTIKA MUHAMMAD SYAHRUR ( KATA NISA’ DALAM QS. ALI IMRAN:14 )
Authors: Fardah Dwi Elok , Sari Maula 
Published: April 2022

Abstrak
Tulisan ini menjelaskan mengenai penafsiran QS. Ali Imran:14 prespektif hermeneutika Muhammad Syahrur. Dalam menafsirkan ayat tersebut pandangan Syahrur berbeda dengan penafsiran yang lain. Syahrur menafsirkan kata nisa’ sebagai suatu hal yang baru karena menurutnya nisa’ dalam ayat tersebut jika dimaknai “perempuan dewasa” itu kurang sesuai. Penelitian ini menggunakan pendekatan liberary research dan menggunakan hermeneutika Muhammad Syahrur dengan menggunakan metode semantik. Syahrur menafsirkan ayat tersebut berawal dari pemahaman fikih Islam dan Tafsir klasik yang yang mana produk-produk pemikiran tersebut tidak lagi sesuai untuk diterapkan pada konteks kehidupan pada abad 20 ini..
Effect of Turbine Blades Transformation on Savonius Turbine Performance
Authors: Abdul Alim Muhammad Iyas 
Published: April 2022

<pre>The purpose of this study was to determine the effect of the transformation of savonius turbine blades using the Cp-TSR curve. The transformation referred to here is the change in the angular of the blade so that the area of the cross section of the blade moving downwind changes, by doing so the negative torque of the turbine obtained from the air flow is reduced. The specimen has 3 variations, namely, without transformation or conventional turbine and transformation of 5 and 10 degrees. With the reduction in the cross sectional area of the turbine blades, the authors hypothesize that the turbine performance will increase, but the blade transformation movement causes a shift in the center of mass which gives rise to vibrations that can directly affect turbine performance, and it could be that the negative effect from these vibrations is much greater than the positive effect from reducing torque. Experiments were carried out using wind tunnels with load variations at 5, 6, and 7 m/s speed variations. The experimental results obtained show that conventional turbines have better performance than turbines with 5</pre><sup>o</sup><pre> and 10</pre><sup>o</sup><pre> blade transformations.</pre>
COVID-19 Vaccine Coverage and Hesitancy Among New York City Parents of Children Aged 5–11 Years
Authors: Teasdale Chloe A. , Ratzan Scott , Rauh Lauren , Lathan Hannah Stuart , Kimball Spencer , El-Mohandes Ayman 
Published: April 2022

Objectives. To measure vaccine uptake and intentions among New York City (NYC) parents of children aged 5 to 11 years following emergency use authorization. Methods. We conducted a survey of 2506 NYC parents of children aged 5 to 11 years. We used survey weights to generate prevalence estimates of vaccine uptake and intentions. Multivariable Poisson regression models generated adjusted prevalence ratios (APRs) of vaccine hesitancy, defined as parents who reported being not very likely or not at all likely to vaccinate their children, or unsure about whether to do so. Results. Overall, 11.9% of NYC parents reported that their child was vaccinated; 51.0% were very or somewhat likely to vaccinate; 8.0% were not sure; 29.1% were not very likely or not at all likely to vaccinate their child. Among vaccine-hesitant parents, 89.9% reported safety concerns and 77.8% had concerns about effectiveness. In multivariable models, more vaccine hesitancy was expressed by non-Hispanic Black parents than by non-Hispanic White parents (APR = 1.41; 95% confidence interval [CI] = 1.17, 1.72) and by parents who were not themselves vaccinated than by parents who were vaccinated (APR = 1.53; 95% CI = 1.32, 1.77). Conclusions. In a survey conducted after authorization of COVID-19 vaccines for children aged 5 to 11 years, significant hesitancy among parents was observed. (Am J Public Health. 2022;112(6):931–936. https://doi.org/10.2105/AJPH.2022.306784 )
Potential application of the hematology analyzer XN-31 prototype for field malaria surveillance in Kenya
Authors: Kagaya Wataru , Takehara Ikki , Kurihara Kyoko , Okomo Gordon , James Kongere , Gitaka Jesse , Kaneko Akira 
Published: April 2022

Abstract
Early and accurate diagnosis is a key component in malaria control programs. Microscopy is the current gold standard, however it requires extensive training and the results largely rely on the skill of the microscopists. Malaria rapid diagnostic tests (RDT) can be performed with minimal training and offer timely diagnosis, but results are not quantitative. Moreover, some Plasmodium falciparum parasites have evolved to evade detection by RDT. Developed by the Sysmex Corporation, the XN-31 prototype (XN-31p) is an automated hematology analyzer capable of detecting Plasmodium-infected erythrocytes and providing species differentiation and stage specific parasite counts in venous blood samples in a minute without any sample preparation. Here we tested the performance of the XN-31p with capillary blood samples and evaluated the effect of sample storage time and temperature on the stability of results. Paired capillary and venous blood samples were collected from 169 outpatients with clinical malaria symptoms in Homa Bay County Referral Hospital, Kenya. Malaria infections were diagnosed with the XN-31p, microscopy, RDT, and PCR. Capillary blood samples were remeasured on the XN-31p after 24 hours of storage at either room (15 to 25°C) or chilled temperatures (2 to 8°C). Identical results in malaria diagnosis were observed between venous and capillary blood samples processed with the XN-31p. The sensitivity and specificity of XN-31p with capillary blood sample relative to PCR were 0.857 and 1.000 and those relative to microscopy and RDT were 1.000 and 0.986 to 1.000, respectively. Parasitemia and complete blood count (CBC) results were stable in capillary blood samples after 24 hours at room or chilled temperatures. These results showed that the XN-31p can be a useful tool to complement existing methods for routine malaria diagnosis in remote settings.
Comparison of ARIMA model and LSTM model in predicting disease burden of occupational pneumoconiosis in Tianjin, China
Authors: Lou HeRen , Wang Xin , Gao Ya , Zeng Qiang 
Published: April 2022

Abstract
Background
To evaluate the epidemic trend of the disease burden of occupational pneumoconiosis in Tianjin and explore appropriate mathematical models to predict the disease burden of pneumoconiosis.
Methods
Disability adjusted life year (DALY) was used to evaluate the disease burden of occupational pneumoconiosis in Tianjin from 1990 to 2019. ARIMA model and LSTM model were used to fit and predict the DALY of pneumoconiosis. Five performance evaluation indexes including Mean Square Error (MSE), Root Mean Squared Error (RMSE), Mean Absolute Error (MAE) and Mean Absolute Percentage Error (MAPE) were selected to compare the prediction effects of the two models.
Restults:
DALY caused by pneumoconiosis in Tianjin showed a fluctuating upward trend from 1990 to 2019, with three peaks in 1995, 2005 and 2015. ARIMA (0, 2, 1) model was determined as the best fitting ARIMA model. The LSTM model with 6 neurons and Adaptive Moment Estimation (Adam) was selected as the best fitting LSTM models. The MSE, RMSE, MAE and MAPE values of LSTM model were lower than those of ARIMA model, indicating that LSTM model had a good prediction effect on pneumoconiosis DALY. The LSTM model was used to predict that the DALY of pneumoconiosis in Tianjin showed a downward trend from 2020 to 2023, which was 2873.82, 2550.19, 2291.02 and 2069.68 person-years, respectively.
Conclusion
LSTM model has good performance in predicting the disease burden of pneumoconiosis and has great application prospect in the field of occupational diseases.
Unmet supportive care needs of caregivers according to medical settings of cancer patients: a cross-sectional study
Authors: Christophe Véronique , ANOTA Amélie , VANLEMMENS Laurence , CORTOT Alexis , CEBAN Tatiana , PIESSEN Guillaume , CHARTON Emilie , BAUDRY Anne-Sophie 
Published: April 2022

Abstract
Purpose. The objectives of this study were to compare the unmet supportive care needs (SCN) of caregivers and describe the 10 most frequent of them according to various cancer settings: phase of cancer care pathway (i.e. treatment vs. follow-up), cancer site (i.e. breast, digestive or lung cancer) and cancer status (i.e. metastatic vs. non-metastatic).Methods. Participants completed a self-reported questionnaire to assess their unmet SCN (SCNS-P&C). According to their cancer settings, non-parametric ANOVA or Mann-Whitney tests were performed to compare the SCNS-P&C scores. The prevalence of caregivers with unmet SCN was described using percentages.Results. Among 583 participants, 523 caregivers (89.71%) completed the questionnaire. Most patients had digestive (47.80%), non-metastatic cancer (67.88%) and were recruited during the follow-up phase (56.21%). The results revealed no significant difference in SCNS-P&C scores according to cancer settings except for caregivers of patients with metastatic cancer, who reported more unmet SCN related to health care service and information needs. The more qualitative item per item analysis seems to indicate the existence of five frequently unsatisfied SCN across situations, especially concerns about the recurrence and reduction of stress in patients, with variable ranking among the most unmet SCN.Conclusion. Although there was no significant difference in unmet SCN scores between medical settings, examining the prevalence of unmet SCN helps identify the issues to focus on when supporting caregivers and developing dedicated consultations or interventions for them.
Breast Cancer Survivors’ Motivations to Participate in an Integrative Program a Qualitative Study
Authors: Sebri Valeria , Durosini Ilaria , Mazzoni Davide , Pravettoni Gabriella 
Published: April 2022

Abstract
Purpose: Participant motivations to take part in a project may evolve during the intervention thanks to lifestyle changes and positive challenges. Integrated programs for breast cancer survivors aim to support their quality of life and positive wellbeing. Personal expectations, needs, and engagement are essential to predict participant adherence to the intervention as well as their possibility to reach positive final outcomes. This study presents a preliminary understanding of the differences between motives and outcomes obtained after an integrated program of both physical and psychological programs to promote well-being in breast cancer survivors. Methods: 45 women answered some questions before and after the integrated program and results were analyzed in accordance with the procedure of the content analysis. Results: Physical and psychological well-being are the two main themes emerged by participants. Interestingly, some differences emerged between the two data collections. Themes such as aesthetic evaluation interest and the need of learning psychological strategies disappeared at the end of the intervention; otherwise, the need to make a distance from the illness experiences emerged as an obtained outcome. Conclusion: The discussion explains these differences and highlights the importance of considering breast cancer needs and motives to take part in interventions to promote quality of life.
Non-Hermitian Control between Absorption and Transparency in Reflectionless Magnonics
Authors: Qian Jie , Rao J.W. , Rao Zejin , An Zhenghua , Gui Yongsheng , Hu Can-Ming 
Published: April 2022

Abstract
Photon propagation with controllable absorption/transmission and meanwhile vanishing reflection is highly desired for many practical applications. Recent works in metamaterials and transformation optics have demonstrated promising progresses including coherent perfect absorption/transparency (PA/PT), electromagnetically induced transparency, cloaking or invisibility etc. However, most of these reported works eluded the non-Hermicity nature of the open systems. Meanwhile, reported works in non-Hermitian physics field focused mainly on the eigenstate properties and less attention has been paid to the reflection condition despite that perfect zero-reflection (PZR) is a prerequisite condition to realize actual applications like PA/PT. Here we demonstrate that the coupled system of two subwavelength-sized magnon resonators on a same microwave transmission line exhibits remarkable non-Hermitian properties such as level repulsion (LR) and level attraction (LA) interactions and meanwhile allows the reflection to be tuned to perfect zero. The observed PZR condition is found to exhibit an infinitely narrow bandwidth and meanwhile an infinite discontinuity in the group delay. This singularity in reflection distinguishes from the eigenstates of magnonic polaritons but can be adjusted on or off resonance with the eigenstates. Accordingly, the absorption and transmission can be flexibly tuned from nearly PA to nearly PT regimes. Our work not only enriches non-Hermitian physics in magnon-photon coupled systems but also brings important implications to practical applications such as microwave circuits, photonic chips and quantum information.
Clinical characteristics of immunoglobulin A vasculitis associated with the Mediterranean fever gene mutation in Japanese patients: a case-based literature review
Authors: Yokoyama Tadafumi , Inoue Natsumi , Sakumura Naoto , Tasaki Yuko , Matsuda Yusuke , Toma Tomoko , Wada Taizo 
Published: April 2022

Abstract
Background. Immunoglobulin A vasculitis (IgAV) is the most common vasculitis of childhood. However, its etiology remains unknown. In the Mediterranean region, 10% of patients with IgAV harbor homozygous and compound heterozygous mutations in the Mediterranean fever (MEFV) gene. Thus, such mutations may be involved in the development of IgAV. Objective. We present a Japanese patient with IgAV harboring MEFV gene mutation. Further, a comprehensive literature analysis was performed to validate the clinical characteristics of Japanese patients with IgAV harboring MEFV mutation. Methods. A 5-year-old girl presented with IgAV. She experienced prolonged abdominal pain, which was steroid-resistant. When treatment with colchicine was started, her abdominal pain disappeared immediately. The serum interleukin-18 levels of the patient and other patients with IgAV and FMF were evaluated using enzyme-linked immunosorbent assay. Moreover, all exons of the MEFV gene were analyzed using the direct sequence method. A comprehensive search of Japanese patients with IgAV harboring MEFV gene mutations in PubMed, Ichushi-Web, and Medical Online was conducted. Results. The serum interleukin-18 level of the patient was higher than that of other patients with IgAV and was similar to that of patients with FMF harboring M694I mutation. In addition, the patient presented with E148Q/M694I mutation. In previous studies, only four patients presented with IgAV harboring MEFV gene mutation in Japan. Conclusion. MEFV gene mutations can be masked if the symptoms of IgAV are prolonged or if patients are refractory to treatment. Moreover, the prevalence of IgAV associated with MEFV gene mutation is low in Japan.
CAR+ and CAR- T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusion
Authors: Louie Raymond , Cai Curtis , Singh Mandeep , Deveson Ira , Ferguson James , Amos Timothy , McGuire Helen , Samir Jerome , Gowrishankar Kavitha , Adikari Thiruni , Balderas Robert , Bishop David , Gottlieb David , Blyth Emily , Micklethwaite Kenneth , Luciani Fabio 
Published: April 2022

Abstract
Chimeric antigen receptor (CAR) T cells have demonstrable efficacy in treating B-cell malignancies. Factors such as product composition, lymphodepletion and immune reconstitution are known to influence functional persistence of CAR+ T cells. However, little is known about the determinants of differentiation and phenotypic plasticity of CAR+ T and immune cells early post-infusion. We report single cell multi-omics analysis of molecular, clonal, and phenotypic profiles of CAR+ T and other immune cells circulating in patients receiving donor-derived products. We used these data to reconstruct a differentiation trajectory, which explained the observed phenotypic plasticity and identified cell fate of CAR+ and CAR- T cells. Following lympho-depletion, endogenous CAR- CD8+ and 𝛾ẟ T cells, clonally expand, and differentiate across heterogenous phenotypes, from a dominant resting or proliferating state into precursor of exhausted T cells, and notably into a terminal NK-like phenotype. In parallel, following infusion, CAR+ T cells undergo a similar differentiation trajectory, showing increased proliferation, metabolic activity and exhaustion when compared to circulating CAR- T cells. The subset of NK-like CAR+ T cells was associated with increasing levels of circulating proinflammatory cytokines, including innate-like IL-12 and IL-18. These results demonstrate that differentiation and phenotype of CAR+ T cells are determined by non-CAR induced signals that are shared with endogenous T cells, and condition the patients’ immune-recovery.
Short-term optimal coordinated operation of a wind-solar-hydro hybrid system based on deep learning and double-layer nesting solution algorithm
Authors: Fugang LI , CHEN Shijun , Xinshuo Zhang , Weibin Huang , Guangwen MA 
Published: April 2022

Abstract
Due to its randomness, intermittence, and volatility, the high-proportional integration of wind and solar power presents considerable challenges for the traditional approaches to the safe and stable operation of power systems. Cascade hydropower stations have a high response speed, high adjustability, and stable output. They can be the optimum candidates for the regulation and compensation of wind and photovoltaic (PV) power generation instability. This study proposed a wind-solar-hydro hybrid system, and investigated its short-term optimal coordinated operation on the basis of deep learning and a double-layer nesting algorithm. A stochastic complementary scheduling model was constructed to maximize the cascade energy storage. To reduce the problem-solving complexity, particle swarm optimization algorithm-dynamic programming (PSO-DP) coupled with the inner and outer nesting optimization algorithm was proposed. The hybrid system was applied to a national comprehensive development base of renewable energy with integrated wind, solar, and hydro power in China. Studies have shown the following: The wind-solar-hydro hybrid system has a certain degree of scalability. The utilisation of deep learning methods can fully consider the uncertainty of wind and solar and fit output scenarios well, the correlation coefficient is above 0.9. The internal and external nested optimisation algorithm, which realises the reasonable and efficient distribution of water and electricity among cascade hydropower stations and improves the future power generation capacity of cascade hydropower stations, was used to solve the problem. This study provided an approach to optimise the operation plan of grid dispatching, including large-scale wind power and PV power, and a valuable reference for the large-scale utilisation of other renewable energy sources worldwide.
The risk of passenger behaviors that influence accident type and severity in metro operation: case-based Monte Carlo analysis
Authors: Lu Ying , Yu Yifan , Jiang Xuepeng , Wang Yong 
Published: April 2022

Abstract
This study aims to examine the risk of each category of behavior related to different accident types and consequences by introducing the Monte Carlo algorithm. Totally about 234 cases were collected to construct a structured dataset, and 12 categories of passengers’ unsafe behaviors related to the four types of metro operation accidents including escalator injury, crowd stampede, pinched by a shielding barrier and fall injury were considered for this analysis. Results showed that although the total behavioral risk of each accident type obeys normal distribution with means between (4, 6] in the Moderate risk level, the variances of pinched by a shielding barrier (1.29) and crowded stampede (1.08) are much higher than escalator injury (0.60) and fall injury (0.59). The top four contributors that resulted in the accident behavioral risks were irregular behavior on the escalator, go on boarding even after the door-close alarm sounded, push each other, and pay no attention to the ground. It was concluded that due to the uncertainty of the behavior occurrence and its consequences, there are differences of the probabilities in different risk levels of the four accidents caused by the various passengers’ unsafe behaviors. Based on the results, risk mitigation measures for different accident types are recommended. This paper provides a quantitative method to compare and analyze the effect of passengers’ unsafe behaviors related to different accident types and severities, which has relative comparative significance and improves the accuracy of judging the probability distribution of risk degree that can provide basis for risk mitigation in metro operation.
A Solution for the Rational Dispatching of Concrete Transport Vehicles
Authors: GUO Zhi-guang , LIU You-fu , AO Chang-jiang 
Published: April 2022

Abstract
The amount of concrete needed in the construction of projects is enormous. The concrete dispatching in construction is, however, chaotic and causes grievous waste due to the tight construction schedule, heavy tasks, and improper transport vehicle dispatching by the constructor. This paper proposes a more realistic fitness function in the vehicle dispatching algorithm and offers a solution to the rational dispatching of concrete transport vehicles. The analysis of the calculation example validates the feasibility of the built model, which provides more appropriate dispatching and more balanced distribution, meets the needs of the worksite and mixing station to the greatest extent and improves the level of project refinement and process management. Therefore, the model is worth promoting in future practice.