bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing ϕ and the F-measure as performance metrics for software-related classifications
Authors: Lavazza Luigi , Morasca Sandro 
Published: October 2022

Abstract
Context
The F-measure has been widely used as a performance metric when selecting binary classifiers for prediction, but it has also been widely criticized, especially given the availability of alternatives such as ϕ (also known as Matthews Correlation Coefficient).

Objectives
Our goals are to (1) investigate possible issues related to the F-measure in depth and show how ϕ can address them, and (2) explore the relationships between the F-measure and ϕ.

Method
Based on the definitions of ϕ and the F-measure, we derive a few mathematical properties of these two performance metrics and of the relationships between them. To demonstrate the practical effects of these mathematical properties, we illustrate the outcomes of an empirical study involving 70 Empirical Software Engineering datasets and 837 classifiers.

Results
We show that ϕ can be defined as a function of Precision and Recall, which are the only two performance metrics used to define the F-measure, and the rate of actually positive software modules in a dataset. Also, ϕ can be expressed as a function of the F-measure and the rates of actual and estimated positive software modules. We derive the minimum and maximum value of ϕ for any given value of the F-measure, and the conditions under which both the F-measure and ϕ rank two classifiers in the same order.

Conclusions
Our results show that ϕ is a sensible and useful metric for assessing the performance of binary classifiers. We also recommend that the F-measure should not be used by itself to assess the performance of a classifier, but that the rate of positives should always be specified as well, at least to assess if and to what extent a classifier performs better than random classification. The mathematical relationships described here can also be used to re-interpret the conclusions of previously published papers that relied mainly on the F-measure as a performance metric.
Climate change threats to cultural and natural heritage UNESCO sites in the Mediterranean
Authors: Kapsomenakis J. , Douvis C. , Poupkou A. , Zerefos S. , Solomos S. , Stavraka T. , Melis N. S. , Kyriakidis E. , Kremlis G. , Zerefos C. 
Published: October 2022

AbstractThe study presents a time-dependent analysis of threats from man-made climate change at 244 UNESCO cultural and natural heritage sites in the Mediterranean. The hazards in our research are estimated by indices based on extremes of heat, fire weather conditions, heavy rainfall days, frost days, changes in mean sea level and aridity at each site. These indices were calculated from regional EUROCORDEX simulations, cover the period 1971–2100 and refer to two IPCC emission scenarios, namely RCP4.5 and RCP8.5. A combined threat index was next calculated, as explained in the text, together with its synergy with local exposure geophysical threats, such as seismicity, topography and proximity to forests and seas. All indices related to man-made climate change show an overall increasing trend from present to the end of the twenty-first century. Some of these increasing trends are intensified after the 2030s and 2040s, except for the case of the days with frost. As the global warming evolves, in both IPCC scenarios studied, the combined threat to the majority of UNESCO sites studied increases. Notable is the amplification of the threat at sites vulnerable to seismic activity and to other local or regional topography and geophysical regional characteristics. Our conclusion is that the majority of heritage sites in the Mediterranean are vulnerable to an increasing rate of threats from man-made global warming and extreme events. Seismic activity is magnifying these threats only at the sites in which that additional hazard applies. Based on the proposed combined threat index, for the worst-case scenario (RCP8.5) 35 monument sites fall within the “high hazard” and 12 sites fall under the category “extreme hazard”.
Towards Formalising Schutz’ Axioms for Minkowski Spacetime in Isabelle/HOL
Authors: Schmoetten Richard , Palmer Jake E. , Fleuriot Jacques D. 
Published: October 2022

AbstractSpecial relativity is a cornerstone of modern physical theory. While a standard coordinate model is well known and widely taught today, multiple axiomatic systems for SR have been constructed over the past century. This paper reports on the formalisation of one such system, which is closer in spirit to Hilbert’s axiomatic approach to Euclidean geometry than to the vector space approach employed by Minkowski. We present a mechanisation in Isabelle/HOL of the system of axioms as well as theorems relating to temporal order. Some proofs are discussed, particularly where the formal work required additional steps, alternative approaches or corrections to Schutz’ prose.
Role of planar faults in martensite formation in nano-polycrystalline iron by molecular dynamics simulation
Authors: Karewar Shivraj , Hidalgo Javier , Sietsma Jilt , Santofimia Maria J. 
Published: October 2022

AbstractThe martensitic transformation in pure Fe and its alloys has been studied over many decades. Several theoretical models have been proposed to describe the atomic motion that leads to the fcc-to-bcc martensitic transformation. However, such models do not account for the effect of pre-existing planar defects such as twin boundaries and stacking faults, present in the high-temperature austenite phase prior to the transformation process. This work systematically studies the role of nano-spaced planar faults with different inter-spacing on the martensitic transformation using molecular dynamics simulations. Research shows that the investigated planar defects affect the nucleation and growth mechanisms during martensite formation, the morphology of the resulting microstructure, the specific atomic path leading to the phase transformation, and the martensite start temperatures. Martensite variants were identified by the analysis of the atomic shears and slip systems during the transformation process. A crystallographic analysis is done to explain the existence of different shear mechanisms of martensite transformation at different locations in the fcc austenite. The present investigation provides fundamental insights into the martensitic transformation process in presence of pre-existing planar defects and can be applied to other material systems, e.g., Fe alloys.
Cyberbullying and Gambling Disorder: Associations with Emotion Regulation and Coping Strategies
Authors: Estévez Ana , Macía Laura , López-González Hibai , Momeñe Janire , Jauregui Paula , Etxaburu Nerea , Granero Roser , Fernández-Aranda Fernando , Mestre-Bach Gemma , Vintró-Alcaraz Cristina , Munguía Lucero , Baenas Isabel , Mena-Moreno Teresa , Mora-Maltas Bernat , Valenciano-Mendoza Eduardo , Jiménez-Murcia Susana 
Published: October 2022

AbstractThe presence of unsuitable coping and emotion regulation strategies in young populations with gambling disorder (GD) and in those who have experienced cyberbullying victimization has been suggested. However, this association has not been explored in depth. In this study, our aim was to analyze individual differences in emotion regulation, coping strategies, and substance abuse in a clinical sample of adolescents and young adult patients with GD (n = 31) and in a community sample (n = 250). Furthermore, we aimed to examine the association between cyberbullying and GD. Participants were evaluated using the Cyberbullying Questionnaire-Victimization, the Canadian Adolescent Gambling Inventory, the Coping Strategies Inventory, the Difficulties in Emotion Regulation Scale, the Alcohol Use Disorders Identification Test and the Drug Use Disorders Identification Test. Structural Equation Modeling was used to explore associations between these factors in a community sample and in a clinical group. In both groups, exposure to cyberbullying behaviors was positively associated with higher emotion dysregulation and the use of maladaptative coping styles. Our findings uphold that adolescents and young adults who were victims of cyberbullying show difficulties in emotion regulation and maladaptive coping strategies when trying to solve problems. The specific contribution of sex, age, gambling severity, emotion regulation, and coping strategies on cyberbullying severity is also discussed. Populations at vulnerable ages could potentially benefit from public prevention policies that target these risk factors.
The effect of functionalized hydroxyapatite on the thermal degradation behaviour and flammability of polyoxymethylene copolymer
Authors: Król-Morkisz Klaudia , Byczyński Łukasz , Majka Tomasz M. , Pielichowski Krzysztof , Pielichowska Kinga 
Published: October 2022

AbstractIn this work, the effect of functionalized hydroxyapatite (HAp-g-PEG) on the thermal degradation behaviour and flammability of polyoxymethylene copolymer (POM_C) was investigated. Organic–inorganic hybrid additive, obtained by grafting of poly(ethylene glycol) on HAp surface using 1,6-hexamethylene diisocyanate as a linker, has been incorporated into POM matrix through an extrusion process. TG analyses show that the incorporation of HAp-g-PEG into POM_C leads to the significant improvement in the thermal stability of the polymer matrix. This is an important finding as POM, being an engineering polymer, suffers from a relatively low thermal stability that limits processing options to develop advanced composite materials. Based on TG results kinetic parameters of the thermal degradation process using Friedman isoconversional method and nonlinear regression method have been calculated; an increase in activation energy of POM degradation process after incorporation of HAp-g-PEG has been found. Thermoanalytical analyses (TG-FTIR/MS) show that incorporation of HAp-g-PEG has no significant effect on the composition of the thermal degradation products. Flammability investigations showed small effect of HAp-g-PEG 600 on the burning time and rate, however, there was a significant reduction in the amount of dripping during the material’s burning process.
Ethical, legal, and social aspects of symptom checker applications: a scoping review
Authors: Müller Regina , Klemmt Malte , Ehni Hans-Jörg , Henking Tanja , Kuhnmünch Angelina , Preiser Christine , Koch Roland , Ranisch Robert 
Published: October 2022

AbstractSymptom Checker Applications (SCA) are mobile applications often designed for the end-user to assist with symptom assessment and self-triage. SCA are meant to provide the user with easily accessible information about their own health conditions. However, SCA raise questions regarding ethical, legal, and social aspects (ELSA), for example, regarding fair access to this new technology. The aim of this scoping review is to identify the ELSA of SCA in the scientific literature. A scoping review was conducted to identify the ELSA of SCA. Ten databases (e.g., Web of Science and PubMed) were used. Studies on SCA that address ELSA, written in English or German, were included in the review. The ELSA of SCA were extracted and synthesized using qualitative content analysis. A total of 25,061 references were identified, of which 39 were included in the analysis. The identified aspects were allotted to three main categories: (1) Technology; (2) Individual Level; and (3) Healthcare system. The results show that there are controversial debates in the literature on the ethical and social challenges of SCA usage. Furthermore, the debates are characterised by a lack of a specific legal perspective and empirical data. The review provides an overview on the spectrum of ELSA regarding SCA. It offers guidance to stakeholders in the healthcare system, for example, patients, healthcare professionals, and insurance providers and could be used in future empirical research to investigate the perspectives of those affected, such as users.
Tectonic Regime as a Control Factor for Crustal Fault Zone (CFZ) Geothermal Reservoir in an Amagmatic System: A 3D Dynamic Numerical Modeling Approach
Authors: Duwiquet H. , Magri F. , Lopez S. , Guillon T. , Arbaret L. , Bellanger M. , Guillou-Frottier L. 
Published: October 2022

AbstractCrustal fault zones provide interesting geological targets for high-temperature geothermal energy source in naturally deep-fractured basement areas. Field and laboratory studies have shown the ability of these systems to let fluid flow down to the brittle–ductile transition. However, several key questions about exploration still exist, in particular the fundamental effect of tectonic regimes on fluid flow in fractured basement domains. Based on poro-elasticity assumption, we considered an idealized 3D geometry and realistic physical properties. We examined a model with no tectonic regime (benchmark experiment) and a model with different tectonic regimes, namely a compressional, an extensional and a strike-slip tectonic regime. Compared to the benchmark experiment, the results demonstrate that different tectonic regimes cause pressure changes in the fault/basement system. The tectonic-induced pressure changes affect convective patterns, onset of convection as well as the spatial extent of thermal plumes and the intensity of temperature anomalies. Driven by poro-elastic forces, temperature anomalies around vertical faults in a strike-slip tectonic regime have a spatial extent that should be considered in preliminary exploratory phases.
Are OMERACT recommendations followed in clinical trials on fibromyalgia? A systematic review of patient-reported outcomes and their measures
Authors: Döhmen Annika , Kock Milan , Fischer Felix , Rose Matthias , Obbarius Alexander , Klapproth Christoph Paul 
Published: October 2022

Abstract
Purpose
Patient-Reported Outcomes (PROs) and its measures (PROMs) are key to outcome assessment in Fibromyalgia (FM) trials. The aim of this review was to investigate which domains and instruments were assessed in recent FM trials and to compare them to recommendations by the Outcome Measures in Rheumatology (OMERACT) initiative. In addition, we investigated the overlap with a generic health assessment approach, i.e. eight domains suggested by the Patient-Reported Outcome Measurement Information System® (PROMIS®).

Methods
In compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic literature search in scientific databases including PubMed, PsycInfo, and Embase was conducted to identify studies that assessed at least two dimensions of health-related quality of life (HRQoL) from 2015 to June 2022. Non-randomized and randomized controlled trials were included in the analysis. We extracted PROs and PROMs used in each study.

Results
From 1845 identified records, 107 records out of 105 studies met the inclusion criteria. Studies investigated 50 PROs using 126 different PROMs. Most frequently assessed domains were pain, depression, fatigue, and anxiety (> 95% of the studies). The disease-specific FIQ was the most frequently applied PROM (82%). Overall, only 9% of the studies covered all domains deemed mandatory by OMERACT. Very few studies covered all eight generic health domains suggested by PROMIS.

Conclusion
The majority of trials covered most OMERACT domains or generic PROMIS health domains. There was, however, great variability in the instruments used to assess the domains, which points at a limited degree of standardization in the field.
College Students’ Perceptions of Ambiguous Hook-ups Involving Alcohol Intoxication
Authors: Celniker Jared B. , Rode Jacob B. , Anderson Katherine B. , Ma Brianna , Ditto Peter H. 
Published: October 2022

AbstractAlcohol intoxication is a prevalent feature of university life and campus sexual assault cases. While previous research has examined how students perceive obvious cases of assault, less is known about how students evaluate more ambiguous sexual scenarios—such as those including two intoxicated individuals. In three survey experiments with college students (N = 990), we examined how manipulating the intoxication (sober vs. drunk) of a man accused of assault (the respondent) influenced perceptions of a hook-up scenario involving an intoxicated woman. Although university policies indicate that respondent intoxication should not influence evaluations of these scenarios, we hypothesized that students would be influenced by cues of respondent intoxication when making judgments of the hook-up and the individuals involved. Students reported that the hook-up was a sexual assault more often when the respondent was sober compared to when he was drunk, and they found sober respondents more responsible for the encounter than drunk respondents. Although effect sizes fluctuated across studies, an internal meta-analysis found evidence of significant (but modest) aggregate effects. Furthermore, perceptions of the respondent’s agency mediated the effects of intoxication on perceptions of respondent responsibility (Studies 2 & 3). We also manipulated whether the respondent should have reasonably known the complainant was drunk (Studies 1 & 2) and whether the complainant or the complainant’s friend reported the incident (Study 3), but these manipulations had little effect on students’ perceptions of the vignettes. We discuss how our findings can guide future research and consider implications of our results for university stakeholders.
Generalizing the constrained equal awards rule
Authors: Dietzenbacher Bas 
Published: October 2022

AbstractThis paper studies axiomatic characterizations of the constrained equal awards rule for bankruptcy problems. We show that many results apply in a much more general context than for which they are originally formulated. In particular, we generalize several axiomatic characterizations based on symmetry, sustainability, and consistency to the domain of bankruptcy problems with nontransferable utility.
Implementing turnaround strategies as an entrepreneurial process
Authors: Baliouskas Peter , Llopis Juan , Gasco Jose , Gonzalez Reyes 
Published: October 2022

AbstractRecovery strategy belongs to the group of rescue/reversing business strategies and is used mainly by companies facing financial or other problems which they are trying to overcome. Moreover, this strategy is alternatively used by companies wishing to prevent future problems. The overall objective of the recovery strategy is to return of this sluggish situation in terms of acceptable levels of profitability. The implementation of turnaround strategy achieved through the implementation of proper planning and specific procedures (processes) like: Change management, divestitures of specific assets (divestment), cost reduction (cost reduction—operating and others), and strategic acquisitions. This strategy is so drastic, that in many senses it is like creating a new company, so it has many similarities to an entrepreneurial process. Obviously, there is a previous experience by managers, but when implementing this radical strategy, they must think in developing something new. The main objective of this paper is to explain how to implement a successful turnaround strategy during a recession phase of the economy. To analyze the turnover strategy, we developed a survey to 152 trading and industrial Greek companies that represent more than 3% of the Greek GDP. The study examines the role of successful turnaround based to whom formulated the strategic plan of the company, investigating the knowledge of the Greek managers on the tactics implemented during a turnaround plan. The paper offers information for management practitioners to understand how to implement a turnaround strategy in a turbulent economic environment, and which tactics apply.
The Problem of Weak Will on the Basis of Leo Tolstoy’s Short Story Father Sergius
Authors: Głąb Anna 
Published: October 2022

AbstractThe author analyses the problem of weak will in Leo Tolstoy’s story Father Sergius. She ponders why the protagonist, a man with such heightened awareness of good and evil, at some point in his life chooses evil. She places the problem of weak will (akrasia) first into the context of the various iterations of determinism and subsequently of the considerations raised by Socrates and Aristotle. As their answers are not fully applicable to the problem of Tolstoy’s titular character, she looks for an explanation to Saint Augustine’s philosophy of free will.
Day-ahead market bidding taking the balancing power market into account
Authors: Klæboe Gro , Braathen Jørgen , Eriksrud Anders Lund , Fleten Stein-Erik 
Published: October 2022

AbstractGeneration companies with controllable units put considerable analysis into the process of bidding into the day-ahead markets for electricity. This article investigates the gain of coordinating price-taking bids to the day-ahead electricity market (DA) and sequentially cleared energy-only markets, such as the Nordic balancing market (BM). A technically detailed case study from the Nordic market is presented. We find that coordinated bidding is hardly worthwhile under current market conditions, but that only a modest increase in the demand for balancing energy will make coordination profitable. If the supply curve for balancing energy is convex, so that the cost of balancing energy is asymmetric, the gains will be even higher. Finally, we find that day-ahead market bid curves that result from coordinated instances provide extra supply at low prices, and lower supply at high prices, compared to sequential bids. This is rational given the anticipated opportunities that the balancing market offers; however, it makes day-ahead bidding appear to exploit market power.
Mitochondrial Dynamin-Related Protein Drp1: a New Player in Cardio-oncology
Authors: Deng Yali , Ngo Doan T. M. , Holien Jessica K. , Lees Jarmon G. , Lim Shiang Y. 
Published: October 2022

Abstract

Purpose of Review
This study is aimed at reviewing the recent progress in Drp1 inhibition as a novel approach for reducing doxorubicin-induced cardiotoxicity and for improving cancer treatment.

Recent Findings
Anthracyclines (e.g. doxorubicin) are one of the most common and effective chemotherapeutic agents to treat a variety of cancers. However, the clinical usage of doxorubicin has been hampered by its severe cardiotoxic side effects leading to heart failure. Mitochondrial dysfunction is one of the major aetiologies of doxorubicin-induced cardiotoxicity. The morphology of mitochondria is highly dynamic, governed by two opposing processes known as fusion and fission, collectively known as mitochondrial dynamics. An imbalance in mitochondrial dynamics is often reported in tumourigenesis which can lead to adaptive and acquired resistance to chemotherapy. Drp1 is a key mitochondrial fission regulator, and emerging evidence has demonstrated that Drp1-mediated mitochondrial fission is upregulated in both cancer cells to their survival advantage and injured heart tissue in the setting of doxorubicin-induced cardiotoxicity.

Summary
Effective treatment to prevent and mitigate doxorubicin-induced cardiotoxicity is currently not available. Recent advances in cardio-oncology have highlighted that Drp1 inhibition holds great potential as a targeted mitochondrial therapy for doxorubicin-induced cardiotoxicity.