bluuebunny/crossref_metadata_2025_split huggingface dataset:
Academic dishonesty when doing homework: How digital technologies are put to bad use in secondary schools
Authors: Désiron Juliette C. , Petko Dominik 
Published: July 2022

AbstractThe growth in digital technologies in recent decades has offered many opportunities to support students’ learning and homework completion. However, it has also contributed to expanding the field of possibilities concerning homework avoidance. Although studies have investigated the factors of academic dishonesty, the focus has often been on college students and formal assessments. The present study aimed to determine what predicts homework avoidance using digital resources and whether engaging in these practices is another predictor of test performance. To address these questions, we analyzed data from the Program for International Student Assessment 2018 survey, which contained additional questionnaires addressing this issue, for the Swiss students. The results showed that about half of the students engaged in one kind or another of digitally-supported practices for homework avoidance at least once or twice a week. Students who were more likely to use digital resources to engage in dishonest practices were males who did not put much effort into their homework and were enrolled in non-higher education-oriented school programs. Further, we found that digitally-supported homework avoidance was a significant negative predictor of test performance when considering information and communication technology predictors. Thus, the present study not only expands the knowledge regarding the predictors of academic dishonesty with digital resources, but also confirms the negative impact of such practices on learning.
Insight into the mechanism of molecular recognition between human Integrin-Linked Kinase and Cpd22 and its implication at atomic level
Authors: García-Marín Javier , Rodríguez-Puyol Diego , Vaquero Juan J. 
Published: July 2022

AbsractPseudokinases have received increasing attention over the past decade because of their role in different physiological phenomena. Although pseudokinases lack several active-site residues, thereby hindering their catalytic activity, recent discoveries have shown that these proteins can play a role in intracellular signaling thanks to their non-catalytic functions. Integrin-linked kinase (ILK) was discovered more than two decades ago and was subsequently validated as a promising target for neoplastic diseases. Since then, only a few small-molecule inhibitors have been described, with the V-shaped pyrazole Cpd22 being the most interesting and characterized. However, little is known about its detailed mechanism of action at atomic level. In this study, using a combination of computational chemistry methods including PELE calculations, docking, molecular dynamics and experimental surface plasmon resonance, we were able to prove the direct binding of this molecule to ILK, thus providing the basis of its molecular recognition by the protein and the effect over its architecture. Our breakthroughs show that Cpd22 binding stabilizes the ILK domain by binding to the pseudo-active site in a similar way to the ATP, possibly modulating its scaffolding properties as pseudokinase. Moreover, our results explain the experimental observations obtained during Cpd22 development, thus paving the way to the development of new chemical probes and potential drugs.
Graphical abstract
Phylogenetic Distribution and Trajectories of Visual Consciousness: Examining Feinberg and Mallatt’s Neurobiological Naturalism
Authors: Ota Koji , Suzuki Daichi G. , Tanaka Senji 
Published: July 2022

AbstractFeinberg and Mallatt, in their presentation of neurobiological naturalism, have suggested that visual consciousness was acquired by early vertebrates and inherited by a wide range of descendants, and that its neural basis has shifted to nonhomologous nervous structures during evolution. However, their evolutionary scenario of visual consciousness relies on the assumption that visual consciousness is closely linked with survival, which is not commonly accepted in current consciousness research. We suggest an alternative idea that visual consciousness is linked to a specific class of agency, consequently justifying their phylogenetic claim. We also examine the implication of their phylogenetic claim: visual consciousness is homologous across vertebrates, but its neural basis is not. This apparent incongruence illustrates a general phenomenon of homology, and that the resulting hierarchical view of visual consciousness and its neural basis can be straightforwardly accommodated by neurobiological naturalism. Throughout these discussions, we aim to address the potential theoretical issues in neurobiological naturalism and refine the picture illustrated by Feinberg and Mallatt regarding phylogenetic distribution and trajectories of visual consciousness.
Perceived Red Tape and Precursors of Turnover: the Roles of Work Engagement and Career Adaptability
Authors: Jiang Zhou , Newman Alexander , Schwarz Gary , Le Huong 
Published: July 2022

AbstractDrawing on job demands-resources theory, we propose that perceived red tape, as a hindrance job demand, triggers attitudinal and behavioral precursors of turnover in employees (turnover intentions and job search behaviors) by reducing their work engagement. In addition, we hypothesize that career adaptability, as a personal resource, buffers the detrimental effects of perceived red tape. In Study 1, three-wave data collected from employees (N = 202) working in Tanzanian public sector organizations supports the finding that work engagement mediates the effect of red tape on turnover intentions. Study 2 confirms this mediation, using data (N = 405) collected at three time points from a Chinese private organization, further verifying the mediating role of work engagement in the effect of red tape on job search behaviors. Supporting the moderating role of career adaptability, Study 2 also found that career adaptability attenuated the influence of red tape on work engagement and, subsequently, on turnover intentions and job search behaviors. Our article theoretically and empirically contributes to the understanding of how and when perceived red tape in organizations leads employees to consider leaving and prepare to leave.
Synthesis and Characterisation of Iodobismuthates Containing N-substituted 1,4-Diazabicyclo[2.2.2]octane
Authors: Cai Yunhe , Chippindale Ann M. , Vaqueiro Paz 
Published: July 2022

Abstract
Two new hybrid iodobismuthates, [C8H17N2][C10H22N2][BiI6] (1) and [C6H12N2]0.5[C10H22N2]3.5[Bi2I10][Bi2I9] (2), have been prepared by solvothermal synthesis in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) and ethanol. Both compounds have been characterized by single-crystal and powder X-ray diffraction, infrared and UV–Vis spectroscopies and thermogravimetric analysis. Structure determination reveals that the crystal structure of 1 contains mononuclear [BiI6]3− anions, whilst 2 contains an unusual combination of dinuclear anions, [Bi2I9]3− and [Bi2I10]4−, consisting of two edge- and two face-sharing [BiI6]3− octahedra, respectively. Mono- and diethylated derivatives of DABCO, which are formed in situ under solvothermal conditions, act as countercations and are located between the discrete anions. The optical band gaps of 1 and 2, which are 2.29(1) and 2.03(2) eV respectively, are consistent with the red color of these compounds, and are comparable to the band gaps measured for other iodobismuthates containing discrete anions.

Graphical Abstract
Two new iodobismuthates, [C8H17N2][C10H22N2][BiI6] (1) and [C6H12N2]0.5[C10H22N2]3.5[Bi2I10][Bi2I9] (2), have been synthesized under solvothermal conditions, and their crystal structures determined by single-crystal X-ray diffraction.
The Effect of Relative Income Concerns on Life Satisfaction: Relative Deprivation and Loss Aversion
Authors: Leites Martín , Ramos Xavier 
Published: July 2022

AbstractIncome comparisons are important for individual well-being. We examine the shape of the relationship between relative income and life satisfaction, and test empirically if the features of the value function of prospect theory carry over to experienced utility. We draw on a unique panel dataset for a middle-income country that allows us to work with an endogenous reference income, which differs for individuals with the same observable characteristics depending on the perception error about their relative position in the distribution. We find the value function for experienced utility to be concave for both positive and, at odds with prospect theory, also negative relative income. Loss aversion holds only for incomes that are sufficiently distant from the reference income. Our heterogeneity analysis shows that the slope of the value function is contingent on people’s personality, social beliefs, and how much they care about income comparisons.
Weak Versus Strong Wall Boundary Conditions for the Incompressible Navier-Stokes Equations
Authors: Eriksson Gustav , Mattsson Ken 
Published: July 2022

AbstractThe pressure-velocity formulation of the incompressible Navier-Stokes equations is solved using high-order finite difference operators satisfying a summation-by-parts property. Two methods for imposing Dirichlet boundary conditions (one strong and one weak) are presented and proven stable using the energy method. Additionally, novel diagonal-norm second-derivative finite difference operators are derived with highly improved boundary accuracy. Accuracy and convergence measurements are presented and verified against theoretical expectations. Numerical experiments also show that subtle effects close to solid walls are more efficiently captured with strong boundary condition imposition methods rather than weak (less degrees of freedom required).
Adolescent Soccer Athletes’ Irrational Beliefs About Basic Psychological Needs are Related to Their Emotional Intelligence and Mental Health
Authors: Devey Alexander , Turner Martin J. , Artiran Murat , Hobson Jennifer 
Published: July 2022

AbstractThere has been a scarcity of research regarding the unique mental health risk factors that adolescent athletes face. The recently proposed Rational Emotive Self Determination Scale for Adolescents (RESD-A) has been suggested to understand some of the antecedent and associative factors of adolescent athlete mental health. The principal aim of this study is to examine the structural and criterion validity of the RESD-A in an athlete sample for the first time. To achieve this aim, two hundred and forty-two club level soccer athletes participated in the study. Confirmatory factor analysis (CFA) was conducted to test the validity of the RESD-A’s factor structure. Partial correlation analyses with the subscales of RESD-A, emotional intelligence, and mental health scores were used to examine criterion validity. Initial results for the structural and criterion validity of the RESD-A with an athlete population are promising. The potential importance, limitations and directions for future research are discussed.
Application of eye-tracking systems integrated into immersive virtual reality and possible transfer to the sports sector - A systematic review
Authors: Pastel Stefan , Marlok Josua , Bandow Nicole , Witte Kerstin 
Published: July 2022

AbstractIn recent years, Virtual Reality (VR) has become a valuable tool in rehabilitation and sports training applications. New technologies offer opportunities to combine various systems and use them for sports-related scientific purposes. For instance, examining the visual perception of athletes within a standardized environment could be helpful to understand the differences between novices and experts in their visual behavior and could further reveal possible training applications for enhancing athletes’ visual attention. The current systematic literature review thematizes the importance of eye-tracking (ET) systems’ usage integrated into head-mounted displays (HMDs) in virtual environments for further inclusion in sports-related usage. An overview of possible implementations is given, and additional recommendations for using the combined technic regarding sports are made. Although only one study examined gaze behavior during sports activity within a standardized virtual environment, 38 relevant papers were identified using the ET systems integrated into the HMDs, which ideas can be transferred to the sports sector. The increased usability and fidelity in the virtual environment enabled through the combined technology were illustrated, and different approaches were listed in using and calculating gaze parameters. This literature review examines the possibility of integrating ET in VR, which can be further used to improve usability, interaction methods, image presentation, and visual perception analyses within future physical training scenarios. The compiled studies have shown that the existing methods are feasible due to the performance of the integrated ET systems but still need to be improved for practical use.
Must Introductory Genetics Start with Mendel?
Authors: Bapty Hannah 
Published: July 2022

Abstract
It is 157 years since Mendel presented his results on hybridisation in peas to the Brünn Society for Natural Science. The discipline of genetics has dramatically changed since then, with technological advancements revealing multifactorial causation and trait variability. Whilst none of this complexity featured in the discovery of classical genetics, Mendel and his peas still dominate teaching today. Must genetics always start from such a simplistic, determinist perspective? A number of recent studies (e.g. Donovan, 2021; Dougherty, 2010; Jamieson & Radick, 2013) have made the case for emphasising the complexity of genetics from the beginning. In this study, I will examine the origins and fate of two earlier attempts at reform, from the 1970s and 1980s. One was from Steven Rose, a biochemist in London and founder of the British Society for Social Responsibility in Science, who developed a genetics course for distance teaching at the Open University. The other was from Garland Allen, a historian of science and influential writer of biology textbooks, including four editions of Study of Biology. Both tried to depart from the standard start-with-Mendel script, in ways that aimed to help students better appreciate not only the complexities of genetics but also embedding genetics—and genetic knowledge—in society. Both met significant resistance, with concerns varying from the creation of unrealistic demands on students to the time and cost of making large-scale changes to textbooks. In closing, I will suggest that the experiences of Rose and Allen hold valuable lessons for reformers of the genetics curriculum today.
Integration of Philosophy of Science in Biomedical Data Science Education to Foster Better Scientific Practice
Authors: Pieterman-Bos Annelies , van Mil Marc H. W. 
Published: July 2022

AbstractBiomedical data science education faces the challenge of preparing students for conducting rigorous research with increasingly complex and large datasets. At the same time, philosophers of science face the challenge of making their expertise accessible for scientists in such a way that it can improve everyday research practice. Here, we investigate the possibility of approaching these challenges together. In current and proposed approaches to biomedical data science education, we identify a dominant focus on only one aspect of conducting scientific research: understanding and using data, research methods, and statistical methods. We argue that this approach cannot solve biomedical data science’s challenge and we propose to shift the focus to four other aspects of conducting research: making and justifying decisions in research design and implementation, explaining their epistemic and non-epistemic effects, balancing varying responsibilities, and reporting scientific research. Attending to these aspects requires learning on different dimensions than solely learning to apply techniques (first dimension). It also requires learning to make choices (second dimension) and to understand the rationale behind choices (third dimension). This could be fostered by integrating philosophical training in biomedical data science education. Furthermore, philosophical training fosters a fourth dimension of learning, namely, understanding the nature of science. In this article, we explain how we identified the five aspects of conducting research and the four dimensions of learning, and why attending to the fourth dimension is essential. We discuss educational approaches to attend to all aspects and dimensions, and present initial design principles to implement these approaches.
Scrum for safety: an agile methodology for safety-critical software systems
Authors: Barbareschi Mario , Barone Salvatore , Carbone Riccardo , Casola Valentina 
Published: July 2022

AbstractIn the last years, agile methodologies are gaining substantial momentum, becoming increasingly popular in a broad plethora of industrial contexts. Unfortunately, many obstacles have been met while pursuing adoption in secure and safe systems, where different standards and operational constraints apply. In this paper, we propose a novel agile methodology for the development and innovation of safety-critical systems. In particular, we developed an extension of the well-known Scrum methodology and discussed the complete workflow. We finally validated the applicability of the proposed methodology over a real case study from the railway domain.
Adenosine receptor signalling in Alzheimer’s disease
Authors: Trinh Phuc N. H. , Baltos Jo-Anne , Hellyer Shane D. , May Lauren T. , Gregory Karen J. 
Published: July 2022

Abstract
Alzheimer’s disease (AD) is the most common dementia in the elderly and its increasing prevalence presents treatment challenges. Despite a better understanding of the disease, the current mainstay of treatment cannot modify pathogenesis or effectively address the associated cognitive and memory deficits. Emerging evidence suggests adenosine G protein-coupled receptors (GPCRs) are promising therapeutic targets for Alzheimer’s disease. The adenosine A1 and A2A receptors are expressed in the human brain and have a proposed involvement in the pathogenesis of dementia. Targeting these receptors preclinically can mitigate pathogenic β-amyloid and tau neurotoxicity whilst improving cognition and memory. In this review, we provide an accessible summary of the literature on Alzheimer’s disease and the therapeutic potential of A1 and A2A receptors. Although there are no available medicines targeting these receptors approved for treating dementia, we provide insights into some novel strategies, including allosterism and the targeting of oligomers, which may increase drug discovery success and enhance the therapeutic response.
Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults
Authors: Toth Luca , Czigler Andras , Hegedus Emoke , Komaromy Hedvig , Amrein Krisztina , Czeiter Endre , Yabluchanskiy Andriy , Koller Akos , Orsi Gergely , Perlaki Gabor , Schwarcz Attila , Buki Andras , Ungvari Zoltan , Toth Peter J. 
Published: July 2022

AbstractImpairment of moment-to-moment adjustment of cerebral blood flow (CBF) to the increased oxygen and energy requirements of active brain regions via neurovascular coupling (NVC) contributes to the genesis of age-related cognitive impairment. Aging is associated with marked deficiency in the vasoprotective hormone insulin-like growth factor-1 (IGF-1). Preclinical studies on animal models of aging suggest that circulating IGF-1 deficiency is causally linked to impairment of NVC responses. The present study was designed to test the hypotheses that decreases in circulating IGF-1 levels in older adults also predict the magnitude of age-related decline of NVC responses. In a single-center cross-sectional study, we enrolled healthy young (n = 31, 11 female, 20 male, mean age: 28.4 + / − 4.2 years) and aged volunteers (n = 32, 18 female, 14 male, mean age: 67.9 + / − 4.1 years). Serum IGF-1 level, basal CBF (phase contrast magnetic resonance imaging (MRI)), and NVC responses during the trail making task (with transcranial Doppler sonography) were assessed. We found that circulating IGF-1 levels were significantly decreased with age and associated with decreased basal CBF. Age-related decline in IGF-1 levels predicted the magnitude of age-related decline in NVC responses. In conclusion, our study provides additional evidence in support of the concept that age-related circulating IGF-1 deficiency contributes to neurovascular aging, impairing CBF and functional hyperemia in older adults.
Regulatory science of natural products
Authors: Goda Yukihiro 
Published: July 2022

AbstractFoods and pharmaceuticals play key roles in public health and welfare and ensuring that these products meet their quality assurance standards is a top priority in health and medical care. Quality assurance of natural products is essential in pharmaceutical sciences because the outset of a medicine is a natural, crude drug. Regulatory science underpins scientific regulations and is closely related to the quality assurance of foods and pharmaceuticals to ensure their safety and efficacy. During my time at the National Institute of Health Sciences, Japan, from 1986 to present, the regulatory science of natural products has been my main research focus. This review discusses 24 studies related to the regulatory science of natural food additives, 26 related to foods, 23 related to borderline products, 16 related to illicit psychotropic mushrooms, plants, and agents, and 57 related to herbal medicines. In later sections, the regulatory science for ethical Kampo products with new dosage forms and herbal medicines that use Kampo extracts as active pharmaceutical ingredients are discussed. My experience from the early twenty-first century in research projects on the bioequivalence of Kampo products and the development of ephedrine alkaloid-free Ephedra Herb extract demonstrate that regulatory science is crucial for developing new drugs.