bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turkish validity and reliability of the Cancer Stigma Scale (CASS-T)
Authors: Çevik Banu , Kav Sultan , Kaynar Pelinsu , Sahin Zeynep Kübra , Tekcan Büşra , Ülker Şeymanur 
Published: June 2022

AbstractObjectivesThis study is aimed to evaluate the validity and reliability of the Cancer Stigma Scale for the Turkish population (CASS-T).MethodsThe sample of the study consisted of 412 students of a foundation university located in Ankara, Turkey. The reliability of the CASS was evaluated using the Cronbach alpha reliability coefficient and item-total score correlations. Exploratory factor analyses were applied to examine the factor structure of the scale and its construct validity. To test the time invariance of the scale, the relationships between the scores obtained from the first and second applications were examined using the intraclass correlation coefficient (ICC).ResultsThe Cronbach's alpha coefficient of CASS-T was 0.83. In the factor analysis, it was confirmed that the scale has a six-dimensional structure in parallel to original version, namelyAvoidance,Severity,Responsibility,Policy opposition,Awkwardness,and Discrimination. The ICC values all remained in the range that indicates the reliability of the 0.63–0.71 to be substantial. The contribution of the six factors of the CASS-T scale to the variance is 57.8.Significance in resultsThe Turkish version of the CASS was confirmed to have good reliability and validity for evaluating stigma toward cancer in Turkish society.
Children and Youth in Strategic Climate Litigation: Advancing Rights through Legal Argument and Legal Mobilization
Authors: Donger Elizabeth 
Published: June 2022

AbstractChildren and young people constitute more than one quarter of all plaintiffs in rights-based strategic climate litigation cases filed globally up to 2021. This article examines the implications of this development for children's environmental rights inside and outside the courtroom, relying on the analysis of case documents, media coverage, and the broader literature on strategic climate litigation and children's rights. The article finds that children are well placed to make powerful arguments for intergenerational justice. Conversely, children's rights arguments that address their current-day grievances are under-utilized. More consistent inclusion of these types of claim could strengthen children's environmental rights, clarifying and enforcing legal obligations towards children in the context of the climate crisis as it unfolds. The involvement of children in strategic climate litigation, moreover, can advance the critical role of this demographic as stakeholder in climate solutions. However, the participation of children also raises ethical and practical dilemmas, which are currently poorly understood and only haphazardly addressed.
Exploring the Deep Ocean Single‐Frequency Microseisms Southwest of Japan in Northern Philippine Sea
Authors: Huang Bin , Xue Mei , Guo Zhen , Song Wenkai 
Published: June 2022

AbstractSingle‐frequency microseisms (SFMs) have been revealed to be only generated in shallow water for decades, while some recent studies reported them in a deep ocean. Using the continuous waveform data recorded by ocean bottom seismometers, we investigate the deep ocean SFMs in the northern Philippine Sea. Based on the spectrum analysis, we find that the SFMs can be detected in deep ocean and the detection is time variable. To determine the source locations of SFMs, we perform polarization analysis and calculate the cross‐correlation coefficients between SFMs on vertical components and ocean wave energy spectra considering the attenuation of SFMs. Both the polarization and correlation results show that the sources nearby stations dominate the observed Rayleigh‐wave SFMs though distant sources also contribute. Our investigation suggests that the SFMs can be generated in a deep ocean likely by infragravity ocean waves interacting with seafloor topography, which is strengthened by strong ocean storms.
The Overlooked Role of the Stratosphere Under a Solar Constant Reduction
Authors: Bednarz Ewa M. , Visioni Daniele , Banerjee Antara , Braesicke Peter , Kravitz Ben , MacMartin Douglas G. 
Published: June 2022

AbstractModeling experiments reducing surface temperatures via an idealized reduction of the solar constant have often been used as analogs for Stratospheric Aerosol Injection (SAI), thereby implicitly assuming that solar dimming captures the essential physical mechanism through which SAI influences surface climate. While the omission of some important processes that otherwise operate under SAI was identified before, here we demonstrate that the imposed reduction in the incoming solar radiation also induces a different stratospheric dynamical response, manifested through a weakening of the polar vortex, that propagates from the upper stratosphere down to the troposphere. The coupled stratospheric‐tropospheric response exerts a previously overlooked first‐order influence on southern hemispheric surface climate in the solar dimming experiments, including on the position of the tropospheric jet and Hadley Circulation and thus, ultimately, precipitation patterns. This perturbation, opposite to that expected under SAI, highlights the need for caution when attributing responses in idealized experiments.
Stress Map of Japan: Detailed Nationwide Crustal Stress Field Inferred From Focal Mechanism Solutions of Numerous Microearthquakes
Authors: Uchide Takahiko , Shiina Takahiro , Imanishi Kazutoshi 
Published: June 2022

AbstractCrustal stress is a crucial parameter for understanding tectonics and assessing the occurrence of large earthquakes. Stress at seismogenic depths over a wide area has been inferred from focal mechanism solutions. The existence of focal mechanism solutions determines the area that can be potentially studied. Therefore, we studied the crustal stress orientations in Japan from focal mechanism solutions of small earthquakes. First, we obtained about 220,000 focal mechanisms using the P‐wave first‐motion polarities picked by a deep learning model. Next, we performed a linearized inversion on the nationwide stress orientation model at a grid of 0.2‐degree intervals. The estimation errors reflect the quality and quantity of focal mechanism solutions. Overall, the results indicate that Japanese islands are under an east–west compressional stress, whereas some areas along the Pacific coast of northeast Japan are under east–west extensional stress. A closer look shows the spatial trends of stress orientation may vary near the geological borders, including the Hinagu and Futagawa faults in Kumamoto Prefecture (Kyushu Island) and the Median Tectonic Line in Shikoku Island. Our stress model also revealed the existence of stress anomalies around Cape Shionomisaki in the Kii peninsula. Most of the active faults are at approximately optimal orientation for the derived stress orientation and stress ratio, although uncertainties in the fault geometry, particularly the dip angle, substantially affect this evaluation. The stress map helps understand the overall vision of the crustal stress in Japan and further study the local stress distribution.
On the Noise Estimation in Super Dual Auroral Radar Network Data
Authors: Ponomarenko P. V. , Bland E. C. , McWilliams K. A. , Nishitani N. 
Published: June 2022

AbstractThe Super Dual Auroral Radar Network (SuperDARN) currently consists of more than thirty high‐frequency (HF, 3–30 MHz) radars covering mid‐latitude to polar regions in both hemispheres. Their major task is to map ionospheric plasma circulation which provides information about the interactions between the solar wind and the near‐Earth's space plasma environment. One of the major factors defining radar data quality is the signal‐to‐noise ratio (SNR), which requires an accurate characterization of the HF noise. The standard SuperDARN data analysis software uses the SNR as part of a set of empirical procedures designed to remove low‐quality data from further analysis. In this study we found that the currently used empirical algorithm systematically underestimates the noise level by up to 40%. Based on comparison of theoretical and observational noise statistics, we resolve this issue by designing and validating a procedure for accurate background noise level estimation. We then propose a simple SNR threshold to replace the existing criteria for excluding low‐quality data. In addition, we show that several aspects of the radar operational regime design, as well as short‐lived anthropogenic radio interference, can adversely affect the quality of the noise estimates at selected radar sites, and we propose ways to mitigate these problems.
Unmet need in Sierra Leone: a national oral health survey of schoolchildren
Authors: Ghotane S. G. , Challacombe S. J. , Don-Davis P. , Kamara D. , Gallagher J. E. 
Published: June 2022

Abstract
Objective
Sierra Leone (SL), in West Africa, with a population of over 7.5 million people has suffered the effects of a civil war previously, and more recently Ebola & Covid-19. Dental care is very limited, mostly in the capital Freetown and the private sector. No dental education is available in the country. The objective of this research was to investigate the oral health needs of schoolchildren at key ages, to inform future action.

Materials and methods
This first national oral health survey of schoolchildren at 6-, 12- and 15-years was conducted in urban and rural settings across all four regions using a multi-stage cluster sampling in line with the WHO guidelines, adapted according to contemporary survey methods to include ‘International Caries Detection and Assessment System (ICDAS)’. Whilst parents were invited to complete a questionnaire for 6-year-old children, 12- and 15-year-olds self-completed a questionnaire. Data were weighted according to age and regional population and analysed using STATA v.15 and SPSS v.22.

Results
A total of 1174 children participated across 22 schools from all four regions. Dental caries was prevalent (over 80% of all age-groups having clinical decay; ICDAS score ≥ 2) and largely untreated. No children had fillings and only 4% had missing teeth. Amongst 6, 12 and 15-year-olds, average decay levels at ICDAS > 3 threshold was 3.47 (primary teeth), 2.94 and 4.30 respectively. Almost, 10% (n = 119) of all children reported experiencing pain in their teeth with 7% (n = 86) children having PUFA lesions present. At least one in five children required one or more dental extractions. ‘Age’ was a significant predictor of dental caries experience and the odds of having dental caries experience was higher in rural areas at D3–6MFT (p < 0.05).

Conclusion
The findings demonstrate a vast unmet oral health need in the children of SL. Using ICDAS as an epidemiological tool in a low-income country provides valuable insight to the pattern of oral disease to inform health service planning. Urgent action is required to address this silent epidemic.
Climatic and tectonic drivers shaped the tropical distribution of coral reefs
Authors: Jones Lewis A. , Mannion Philip D. , Farnsworth Alexander , Bragg Fran , Lunt Daniel J. 
Published: June 2022

AbstractToday, warm-water coral reefs are limited to tropical-to-subtropical latitudes. These diverse ecosystems extended further poleward in the geological past, but the mechanisms driving these past distributions remain uncertain. Here, we test the role of climate and palaeogeography in shaping the distribution of coral reefs over geological timescales. To do so, we combine habitat suitability modelling, Earth System modelling and the ~247-million-year geological record of scleractinian coral reefs. A broader latitudinal distribution of climatically suitable habitat persisted throughout much of the Mesozoic–early Paleogene due to an expanded tropical belt and more equable distribution of shallow marine substrate. The earliest Cretaceous might be an exception, with reduced shallow marine substrate during a ‘cold-snap’ interval. Climatically suitable habitat area became increasingly skewed towards the tropics from the late Paleogene, likely steepening the latitudinal biodiversity gradient of reef-associated taxa. This was driven by global cooling and increases in tropical shallow marine substrate resulting from the tectonic evolution of the Indo-Australian Archipelago. Although our results suggest global warming might permit long-term poleward range expansions, coral reef ecosystems are unlikely to keep pace with the rapid rate of anthropogenic climate change.
Proposed energy-metabolisms cannot explain the atmospheric chemistry of Venus
Authors: Jordan Sean , Shorttle Oliver , Rimmer Paul B. 
Published: June 2022

AbstractLife in the clouds of Venus, if present in sufficiently high abundance, must be affecting the atmospheric chemistry. It has been proposed that abundant Venusian life could obtain energy from its environment using three possible sulfur energy-metabolisms. These metabolisms raise the possibility of Venus’s enigmatic cloud-layer SO2-depletion being caused by life. We here couple each proposed energy-metabolism to a photochemical-kinetics code and self-consistently predict the composition of Venus’s atmosphere under the scenario that life produces the observed SO2-depletion. Using this photo-bio-chemical kinetics code, we show that all three metabolisms can produce SO2-depletions, but do so by violating other observational constraints on Venus’s atmospheric chemistry. We calculate the maximum possible biomass density of sulfur-metabolising life in the clouds, before violating observational constraints, to be ~10−5 − 10−3 mg m−3. The methods employed are equally applicable to aerial biospheres on Venus-like exoplanets, planets that are optimally poised for atmospheric characterisation in the near future.
Evidence of water on the lunar surface from Chang’E-5 in-situ spectra and returned samples
Authors: Liu Jianjun , Liu Bin , Ren Xin , Li Chunlai , Shu Rong , Guo Lin , Yu Songzheng , Zhou Qin , Liu Dawei , Zeng Xingguo , Gao Xingye , Zhang Guangliang , Yan Wei , Zhang Hongbo , Jia Lihui , Jin Shifeng , Xu Chunhua , Deng Xiangjin , Xie Jianfeng , Yang Jianfeng , Huang Changning , Zuo Wei , Su Yan , Wen Weibin , Ouyang Ziyuan 
Published: June 2022

AbstractThe distribution range, time-varying characteristics, and sources of lunar water are still controversial. Here we show the Chang’E-5 in-situ spectral observations of lunar water under Earth’s magnetosphere shielding and relatively high temperatures. Our results show the hydroxyl contents of lunar soils in Chang’E-5 landing site are with a mean value of 28.5 ppm, which is on the weak end of lunar hydration features. This is consistent with the predictions from remote sensing and ground-based telescopic data. Laboratory analysis of the Chang’E-5 returned samples also provide critical clues to the possible sources of these hydroxyl contents. Much less agglutinate glass contents suggest a weak contribution of solar wind implantation. Besides, the apatite present in the samples can provide hydroxyl contents in the range of 0 to 179 ± 13 ppm, which shows compelling evidence that, the hydroxyl-containing apatite may be an important source for the excess hydroxyl observed at this young mare region.
A framework for the general design and computation of hybrid neural networks
Authors: Zhao Rong , Yang Zheyu , Zheng Hao , Wu Yujie , Liu Faqiang , Wu Zhenzhi , Li Lukai , Chen Feng , Song Seng , Zhu Jun , Zhang Wenli , Huang Haoyu , Xu Mingkun , Sheng Kaifeng , Yin Qianbo , Pei Jing , Li Guoqi , Zhang Youhui , Zhao Mingguo , Shi Luping 
Published: June 2022

AbstractThere is a growing trend to design hybrid neural networks (HNNs) by combining spiking neural networks and artificial neural networks to leverage the strengths of both. Here, we propose a framework for general design and computation of HNNs by introducing hybrid units (HUs) as a linkage interface. The framework not only integrates key features of these computing paradigms but also decouples them to improve flexibility and efficiency. HUs are designable and learnable to promote transmission and modulation of hybrid information flows in HNNs. Through three cases, we demonstrate that the framework can facilitate hybrid model design. The hybrid sensing network implements multi-pathway sensing, achieving high tracking accuracy and energy efficiency. The hybrid modulation network implements hierarchical information abstraction, enabling meta-continual learning of multiple tasks. The hybrid reasoning network performs multimodal reasoning in an interpretable, robust and parallel manner. This study advances cross-paradigm modeling for a broad range of intelligent tasks.
Morphological pseudotime ordering and fate mapping reveal diversification of cerebellar inhibitory interneurons
Authors: Wang Wendy Xueyi , Lefebvre Julie L. 
Published: June 2022

AbstractUnderstanding how diverse neurons are assembled into circuits requires a framework for describing cell types and their developmental trajectories. Here we combine genetic fate-mapping, pseudotemporal profiling of morphogenesis, and dual morphology and RNA labeling to resolve the diversification of mouse cerebellar inhibitory interneurons. Molecular layer interneurons (MLIs) derive from a common progenitor population but comprise diverse dendritic-, somatic-, and axon initial segment-targeting interneurons. Using quantitative morphology from 79 mature MLIs, we identify two discrete morphological types and presence of extensive within-class heterogeneity. Pseudotime trajectory inference using 732 developmental morphologies indicate the emergence of distinct MLI types during migration, before reaching their final positions. By comparing MLI identities from morphological and transcriptomic signatures, we demonstrate the dissociation between these modalities and that subtype divergence can be resolved from axonal morphogenesis prior to marker gene expression. Our study illustrates the utility of applying single-cell methods to quantify morphology for defining neuronal diversification.
Accelerating amorphous polymer electrolyte screening by learning to reduce errors in molecular dynamics simulated properties
Authors: Xie Tian , France-Lanord Arthur , Wang Yanming , Lopez Jeffrey , Stolberg Michael A. , Hill Megan , Leverick Graham Michael , Gomez-Bombarelli Rafael , Johnson Jeremiah A. , Shao-Horn Yang , Grossman Jeffrey C. 
Published: June 2022

AbstractPolymer electrolytes are promising candidates for the next generation lithium-ion battery technology. Large scale screening of polymer electrolytes is hindered by the significant cost of molecular dynamics (MD) simulation in amorphous systems: the amorphous structure of polymers requires multiple, repeated sampling to reduce noise and the slow relaxation requires long simulation time for convergence. Here, we accelerate the screening with a multi-task graph neural network that learns from a large amount of noisy, unconverged, short MD data and a small number of converged, long MD data. We achieve accurate predictions of 4 different converged properties and screen a space of 6247 polymers that is orders of magnitude larger than previous computational studies. Further, we extract several design principles for polymer electrolytes and provide an open dataset for the community. Our approach could be applicable to a broad class of material discovery problems that involve the simulation of complex, amorphous materials.
Brain-wide reconstruction of inhibitory circuits after traumatic brain injury
Authors: Frankowski Jan C. , Tierno Alexa , Pavani Shreya , Cao Quincy , Lyon David C. , Hunt Robert F. 
Published: June 2022

AbstractDespite the fundamental importance of understanding the brain’s wiring diagram, our knowledge of how neuronal connectivity is rewired by traumatic brain injury remains remarkably incomplete. Here we use cellular resolution whole-brain imaging to generate brain-wide maps of the input to inhibitory neurons in a mouse model of traumatic brain injury. We find that somatostatin interneurons are converted into hyperconnected hubs in multiple brain regions, with rich local network connections but diminished long-range inputs, even at areas not directly damaged. The loss of long-range input does not correlate with cell loss in distant brain regions. Interneurons transplanted into the injury site receive orthotopic local and long-range input, suggesting the machinery for establishing distant connections remains intact even after a severe injury. Our results uncover a potential strategy to sustain and optimize inhibition after traumatic brain injury that involves spatial reorganization of the direct inputs to inhibitory neurons across the brain.
A westerly wind dominated Puna Plateau during deposition of upper Pleistocene loessic sediments in the subtropical Andes, South America
Authors: Pullen Alex , Barbeau David L. , Leier Andrew L. , Abell Jordan T. , Ward Madison , Bruner Austin , Fidler Mary Kate 
Published: June 2022

AbstractThe Tafí del Valle depression (~27° S) in the eastern Andes of Argentina provides a record of late Pleistocene dust deposition in the subtropics of South America. We present large-nU-Pb geochronology data for detrital zircons from upper Pleistocene loess-paleosol deposits. When compared to regional data, the age spectra from the Tafí del Valle samples are most like the southern Puna Plateau, supporting derivation largely from the west and northwest. This runs counter to hypotheses suggesting these loessic sediments were derived from the low elevation plains to the east or extra-Andean Patagonia. Mapping of linear wind erosion features on the Puna Plateau yield a mean orientation of 125.7° (1 s.d. = 12.4°). These new data and existing records are consistent with a westerly-northwesterly dominated (upper- and lower-level) wind system over the southern Puna Plateau (to at least ~27° S) during periods of high dust accumulation in Tafí del Valle.
Structural remodeling of ribosome associated Hsp40-Hsp70 chaperones during co-translational folding
Authors: Chen Yan , Tsai Bin , Li Ningning , Gao Ning 
Published: June 2022

AbstractRibosome associated complex (RAC), an obligate heterodimer of HSP40 and HSP70 (Zuo1 and Ssz1 in yeast), is conserved in eukaryotes and functions as co-chaperone for another HSP70 (Ssb1/2 in yeast) to facilitate co-translational folding of nascent polypeptides. Many mechanistic details, such as the coordination of one HSP40 with two HSP70s and the dynamic interplay between RAC-Ssb and growing nascent chains, remain unclear. Here, we report three sets of structures of RAC-containing ribosomal complexes isolated from Saccharomyces cerevisiae. Structural analyses indicate that RAC on the nascent-chain-free ribosome is in an autoinhibited conformation, and in the presence of a nascent chain at the peptide tunnel exit (PTE), RAC undergoes large-scale structural remodeling to make Zuo1 J-Domain more accessible to Ssb. Our data also suggest a role of Zuo1 in orienting Ssb-SBD proximal to the PTE for easy capture of the substrate. Altogether, in accordance with previous data, our work suggests a sequence of structural remodeling events for RAC-Ssb during co-translational folding, triggered by the binding and passage of growing nascent chain from one to another.