bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic Syndrome (MetS), Systemic Inflammatory Response Syndrome (SIRS), and Frailty: Is There any Room for Good Outcome in the Elderly Undergoing Emergency Surgery?
Authors: Fransvea Pietro , Costa Gianluca , Lepre Luca , Capolupo Gabriella Teresa , Carannante Filippo , Puccioni Caterina , Costa Alessandro , La Greca Antonio , Giovinazzo Francesco , Sganga Gabriele ,   on behalf of the IGo-GIPS study group
Published: June 2022

BackgroundPatients with MetS or SIRS experience higher rates of mortality and morbidity, across both cardiac and noncardiac surgery. Frailty assessment has acquired increasing importance in recent years as it predisposes elderly patients to a worse outcome. The aim of our study was to investigate the influence of MetS, SIRS, and with or without frailty on elderly patients undergoing emergency surgical procedures.MethodsWe analyzed data of all patients with nonmalignant diseases requiring an emergency surgical procedure from January 2017 to December 2020. The occurrence of MetS was identified using modified definition criteria used by the NCEP-ATP III Expert Panel: obesity, hypertension, diabetes, or if medication for high triglycerides or for low HDL cholesterol was taken. Systemic inflammatory response syndrome (SIRS) was evaluated according to the original consensus study (Sepsis-1). The frailty profile was investigated by the 5-modified Frailty Index (5-mFI) and the Emergency Surgery Frailty Index (EmSFI). Postoperative complications have been reported and categorized according to the Clavien–Dindo (C–D) classification system. Morbidity and mortality have been mainly considered as the 30-day standard period definition.ResultsOf the 2,318 patients included in this study, 1,010 (43.6%) fulfilled the criteria for MetS (MetsG group). Both 5-Items score and EmsFI showed greater fragility in patients with MetS. All patients with MetS showed more frequently a CACI index greater than 6. The occurrence of SIRS was higher in MetSG. LOS was longer in patients with MetS (MetSG 11.4 ± 12 days vs. n-MetSG 10.5 ± 10.2 days, p = 0.046). MetSG has a significantly higher rate of morbidity (353 (35.%) vs. 385 (29.4%), p = 0.005). The mortality rate in patients with MetS (98/1010, 10%) was similar to that in patients without it (129/1308, 10%). Considering patients with MetS who developed SIRS and those who had frailty or both, the occurrence of these conditions was associated with a higher rate of morbidity and mortality.ConclusionImpact of MetS and SIRS on elderly surgical patient outcomes has yet to be fully elucidated. The present study showed a 43.6% incidence of MetS in the elderly population. In conclusion, age per se should be not considered anymore as the main variable to estimate patient outcomes, while MetS and Frailty should have always a pivotal role.
Reducing short-acting beta-agonist overprescribing in asthma: lessons from a quality-improvement prescribing project in East London
Authors: De Simoni Anna , Hajmohammadi Hajar , Pfeffer Paul , Cole Jim , Griffiths Chris , Hull Sally A 
Published: June 2022

BackgroundExcess prescription and use of short-acting beta-agonist (SABA) inhalers is associated with poor asthma control and increased risk of hospital admission.AimTo quantify the prevalence and identify the predictors of SABA overprescribing.Design and settingA cross-sectional study using anonymised clinical and prescribing data from the primary care records in three contiguous East London boroughs.MethodPrimary care medical record data for patients aged 5–80 years, with ‘active’ asthma were extracted in February 2020. Explanatory variables included demography, asthma management, comorbidities, and prescriptions for asthma medications.ResultsIn the study population of 30 694 people with asthma, >25% (1995/7980), were prescribed ≥6 SABA inhalers in the previous year. A 10-fold variation between practices (<6% to 60%) was observed in the proportion of patients on ≥6 SABA inhalers/year. By converting both SABAs and inhaled corticosteroids (ICSs) to standard units the accuracy of comparisons was improved across different preparations. In total, >25% of those taking ≥6 SABAs/year were underusing ICSs, this rose to >80% (18 170/22 713), for those prescribed <6 SABAs/year. Prescription modality was a strong predictor of SABA overprescribing, with repeat dispensing strongly linked to SABA overprescribing (odds ratio 6.52, 95% confidence interval = 4.64 to 9.41). Increasing severity of asthma and multimorbidity were also independent predictors of SABA overprescribing.ConclusionIn this multi-ethnic population a fifth of practices demonstrate an overprescribing rate of <20% a year. Based on previous data, supporting practices to enable the SABA ≥12 group to reduce to 4–12 a year could potentially save up to 70% of asthma admissions a year within that group.
Pengaruh Umur dan Paritas dengan Penggunaan KB Suntik 1 Bulan
Authors: Susmita  , Helen Evelina Siringoringo  
Published: June 2022

Keluarga Berencana atau KB yaitu mewujudkan keluarga berkualitas melalui promosi, perlindungan, dan bantuan dalam mewujudkan hak-hak reproduksi serta penyelenggaraan pelayanan, pengaturan, dan dukungan yang diperlukan untuk membentuk keluarga dengan usia kawin yang ideal, mengatur jumlah, jarak dan usia ideal melahirkan anak, mengatur kehamilan serta membina ketahanan dan kesejahteraan keluarga. Tujuan penelitian mengetahui pengaruh umur dan paritas dengan penggunaan KB suntik 1 bulan. Desain penelitian menggunakan metode survey analitik dengan rancangan penelitian cross sectional. Penelitian ini menggunakan data sekunder. Sampel penelitian berjumlah 86 responden. Tehnik Pengambilan sampel secara total sampling. Analisa yang digunakan univariat dan bivariat dengan uji Chi -Square. Hasil penelitian didapatkan umur (20 – 35 tahun) sebanyak 53 (61,6%), umur (< 20 dan > 35 tahun) sebanyak 33 (38,4%), paritas ≤ 2 anak sebanyak 46 (53,5%) dan paritas > 2 anak sebanyak 40 (46,5%). Hasil bivariat menunjukkan terdapat hubungan antara umur (p = 0,002) dan paritas p = 0,000) dengan penggunaan KB suntik 1 bulan.
Black Box Testing dengan Teknik Equivalence Partitions Pada Aplikasi Android M-Magazine Mading Sekolah
Authors: Novalia Elfina , Voutama Apriade 
Published: June 2022

Pengujian aplikasi/software merupakan tahapan untuk memeriksa apakah suatu program berjalan dengan semestinya atau belum jika masih ada kesalahan maka harus diperbaiki sehingga program yang dibuat mencapai tujuan dan memiliki kualitas yang baik. Salah satu software yang perlu dilakukan pengujian yaitu aplikasi M-Magazine. M-Magazine adalah aplikasi berbasis android yang digunakan sebagai mading secara digital di Sekolah tingkat atas yang terdiri dari dua bagian yaitu berbasis Website sebagai panel admin dan berbasis mobile yang digunakan pada perangkat mobile user. Pengujian dilakukan menggunakan Black Box dengan teknik Equivalence Partitions. Pengujian Black Box digunakan untuk melihat program dari sisi laur apakah sesuai dengan fungsi program tanpa mengetahui kode program sedangkan Teknik yang dipakai yaitu Equivalence Partitions merupakan teknik pengujian berdasarkan masukkan data disetiap form atau halaman dari aplikasi M-Magazine setiap masukan nilai akan diuji dan dikelompokkan sesuai test case dengan hasil bernilai bernilai valid ataupun tidak valid. Tujuan adanya pengujian pada Aplikasi M-Magazine ini untuk mendekteksi dan meminilisir kegagalan saat diimplementasikan sehingga kesalahan ditemukan dapat diperbaiki lebih cepat.
Are We Overestimating the Effect of Indocyanine Green on Leaks Following Colorectal Surgery: A Systematic Review and Meta-Analysis
Authors: Verhoeff Kevin , Mocanu Valentin , Fang Breanna , Dang Jerry , Kung Janice Y. , Switzer Noah J. , Birch Daniel W. , Karmali Shahzeer 
Published: June 2022

ABSTRACT

Introduction
Systematic reviews of retrospective studies suggest that indocyanine green (ICG) angiography reduces anastomotic leak (AL) and improves postoperative outcomes. This systematic review and meta-analysis evaluates colorectal surgery outcomes following ICG use with comparison of results found in randomized controlled trials (RCTs) and retrospective studies.

Methods
A systematic search was conducted of studies evaluating ICG in colorectal surgery with more than five patients. Systematic search of MEDLINE, Embase, Scopus, and Web of Science was conducted in August 2021 and this study followed PRISMA and MOOSE guidelines. Primary outcome was AL. Meta-analysis was conducted with RevMan 5.4.

Results
Overall, 2403 studies were retrieved with 28 total studies including three RCTs meeting criteria. RCTs included 964 patients, whereas other studies comprised 7327 patients with 44.6% receiving ICG. The ICG and non-ICG cohorts were similar with respect to age (62.6 vs 63.1 years), sex (45.1% vs 43.1% female), smoking (22.4% vs 25.3% smokers), and diabetes (13.4% vs 14.2%), respectively. Anastomotic height (6.5 vs 6.8 cm) and technique (78.7% vs 74.8% stapled) were also comparable. With retrospective studies included, ICG was associated with AL reduction (odds ratio [OR] 0.41; 95% CI, 0.32–0.53; p &lt; 0.001) and reoperation for AL (OR 0.64; 95% CI, 0.43–0.95; p = 0.03), with pronounced effects for rectal anastomoses (OR 0.31; 95% CI, 0.21–0.44; p &lt; 0.001). RCT evidence suggests a much smaller effect size (OR 0.64; 95% CI, 0.42–0.99; p = 0.04), and no reduction in AL reoperation (OR 0.72; 95% CI, 0.29–1.80; p = 0.48) or length of stay (LOS).

Conclusion
Retrospective studies suggest reduced AL, reoperation for AL, and LOS with ICG angiography. However, RCTs suggest a smaller effect size and do not demonstrate reduced reoperation or LOS. Additional RCTs are required before widespread ICG uptake.
Contemporary Applications of Shariah Maxims Related to Needs and Necessities in Medical Field
Authors: Hafiz Aziz ur Rahman  
Published: June 2022

Emergence of biomedical research and innovation with an unprecedented speed has created number of opportunities and challenges for policy makers. On the one hand, it is now possible to introduce tailor-made personal medication regime for an ailing patient to offer state of the art treatments. On the other hand, several ethical and legal issues have been raised due to the complex nature of emerging technologies. Policy makers all over the world are constantly addressing these challenges by continuously upgrading their respective professional and regulatory frameworks. This article is an attempt to highlight Shariah maxims which have contemporary application in medical field. Lately, there has been a lot of interest in the debate of Shariah maxims and many scholars have used maxims-based analytical frameworks to show the dynamic application of Islamic law. This article builds upon those works by focusing on issues related to the medical field.
Характерні особливості формування харківської професійно-академічної бандурної школи
Authors: Даюк Жанна , Ковлева Марія 
Published: June 2022

У статті бандурне мистецтво представлено як мистецький феномен в історії національної музичної культури, що поєднує в собі народно-фольклорні мотиви й академічні традиції. Окреслено етапи становлення та розвитку професійного бандурного мистецтва, зокрема схарактеризовано процеси формування харківської академічної школи гри на бандурі, доведено, що саме харківський освітній осередок став базою фахової музичної освіти в Україні, першим методичним центром, що поєднав усі без винятку регіональні школи та сприяв загальному поширенню професіоналізму в бандурному мистецтві, широкому залученню його до просвітницької діяльності.
Проаналізовано діяльність очільника харківської академічної бандурної школи – Гната Хоткевича – відомого етнографа, бандуриста-віртуоза, композитора, організатора навчальних і професійних художніх колективів, основоположника професійного бандурного мистецтва, який заклав основи теорії музики і народного музичного професіоналізму, запровадивши нові жанри виконання творів на бандурі та новий тип бандурного супроводу, першим в Україні сформував фонд педагогічного і концертного репертуару для бандури й оркестру бандуристів, зробив особливий вклад у розвиток професійної майстерності виконавців та популяризації бандурного мистецтва загалом.
Symmetry and spatial ability enhance change detection in visuospatial structures
Authors: He Chuanxiuyue , Rathbun Zoe , Buonauro Daniel , Meyerhoff Hauke S. , Franconeri Steven L. , Stieff Mike , Hegarty Mary 
Published: June 2022

AbstractScience, Technology, Engineering, and Mathematics (STEM) domains require people to recognize and transform complex visuospatial displays that appear to vastly exceed the limits of visuospatial working memory. Here, we consider possible domain-general mechanisms that may explain this advantage: capitalizing on symmetry, a structural regularity that can produce more efficient representations. Participants briefly viewed a structure made up of three-dimensional connected cubes of different colors, which was either asymmetrical or symmetrical. After a short delay, they were asked to detect a change (colors swapping positions) within a rotated second view. In change trials, the second display always had an asymmetrical structure. The presence of symmetry in the initial view improved change detection, and performance also declined with angular disparity of the encoding and test displays. People with higher spatial ability performed better on the change-detection task, but there was no evidence that they were better at leveraging symmetry than low-spatial individuals. The results suggest that leveraging symmetrical structures can help people of all ability levels exceed typical working memory limits by constructing more efficient representations and substituting resource-demanding mental rotation operations with alternative orientation-independent strategies.
Statistics of Water-group Band Ion Cyclotron Waves in Saturn's Inner Magnetosphere Based on 13 yr of Cassini Measurements
Authors: Long Minyi , Cao Xing , Gu Xudong , Ni Binbin , Qu Shaojie , Ye Shengyi , Yao Zhonghua , Wu Siyuan , Xu Yan 
Published: June 2022

Abstract
Based on Cassini observations from 2004 to 2016, we perform a comprehensive analysis of the statistical distribution of the occurrence rate, averaged amplitude, wave normal angle (WNA), ellipticity, and power spectral intensity of ion cyclotron waves in Saturn's inner magnetosphere. Our results show that ion cyclotron waves mainly occur between the orbits of Enceladus and Dione near the equatorial region (∣λ∣ < 20°), with higher occurrence rates in the northern hemisphere than the southern hemisphere. The averaged wave amplitudes vary between 0.1 and 2 nT with a strong day–night asymmetry and a pronounced minimum at the equator. Saturnian ion cyclotron waves are predominantly left-handed polarized with small WNAs near the equator and become linearly polarized with larger WNAs at higher latitudes. The major wave power occurs frequently at frequencies of 0.5–1.2

f

w
+

, where

f

w
+

is the equatorial gyrofrequency of H2O+ ions, with the strongest intensity (>∼10 nT2 Hz−1) at L ∼ 6.5 statistically present in the midnight sector.
Long-term Behavioral Changes During the COVID-19 Pandemic and Impact of Vaccination in Patients With Inflammatory Rheumatic Diseases
Authors: Glintborg Bente , Jensen Dorte Vendelbo , Terslev Lene , Hendricks Oliver , Østergaard Mikkel , Rasmussen Simon Horskjær , Jensen Mogens Pfeiffer , Adelsten Thomas , Colic Ada , Danebod Kamilla , Kildemand Malene , Loft Anne Gitte , Munk Heidi Lausten , Pedersen Jens Kristian , Østgård René Drage , Sørensen Christian Møller , Krogh Niels Steen , Agerbo Jette Nørgaard , Ziegler Connie , Hetland Merete Lund 
Published: June 2022

ObjectiveTo explore anxiety and self-isolation in patients with inflammatory rheumatic disease (IRD)15 months into the coronavirus disease 2019 (COVID-19) pandemic, including attitudes toward and effects of SARS-CoV-2 vaccination.MethodsA nationwide online survey was conducted at 3 timepoints: May 2020, November 2020, and May 2021. Patients with IRD followed in the Danish Rheumatology Quality Registry (DANBIO) were asked about the effects of the pandemic, including SARS-CoV-2 infection and their behavior, anxiety, and concerns. The May 2021 survey included attitudes toward SARS-CoV-2 and influenza vaccination. Characteristics associated with self-isolation in May 2021 were explored with adjusted logistic regression analyses that included patient characteristics and SARS-CoV-2 vaccination status.ResultsRespondents to surveys 1, 2, and 3 included 12,789; 14,755; and 13,921 patients, respectively; 64% had rheumatoid arthritis and 63% were female. Anxiety and concerns were highest in May 2020 and decreased to stable levels in November 2020 and May 2021; 86%, 50%, and 52% of respondents reported self-isolation, respectively. In May 2021, 4% of respondents self-reported previous SARS-CoV-2 infection. The SARS-CoV-2 vaccine acceptance rate was 86%, and the proportion of patients vaccinated against influenza had increased from 50% in winter 2019-2020 to 64% in winter 2020-2021. The proportion of patients with anxiety appeared similar among those vaccinated and unvaccinated against SARS-CoV-2. In multivariable analyses, being unvaccinated, female gender, receiving biologic drugs, and poor quality of life were independently associated with self-isolation.ConclusionLevels of anxiety and self-isolation decreased after the initial lockdown period in patients with IRD. Half of the patients reported self-isolation in May 2021, a phase that included widespread reopening of society and large-scale vaccination. The lack of prepandemic data prevented a full understanding of the long-term effects of the pandemic on anxiety and self-isolation in patients with IRD.
Evaluation of Patients With Rheumatoid Arthritis in Teleconsultation During the First Wave of the COVID-19 Pandemic
Authors: Avouac Jérôme , Molto Anna , Frantz Camélia , Wanono Sarah , Descamps Elise , Fogel Olivier , Combier Alice , Poiroux Lucile , Miceli-Richard Corinne , Allanore Yannick 
Published: June 2022

Objective To describe which variables were collected by rheumatologists to monitor patients with rheumatoid arthritis (RA) during teleconsultation and identify which ones have more impact on clinician intervention. Methods Retrospective monocentric, routine care cross-sectional study including patients with RA seen in teleconsultation between March and September 2020. Available variables assessing disease status were collected in teleconsultation files. Clinician intervention was defined by treatment escalation and/or the need for a rapid face-to-face consultation or day hospitalization. Results One hundred forty-three patients with RA were included (116 females, mean age of 58 [SD 16] yrs, mean disease duration of 14 [SD 11] yrs). The presence or absence of patient self-reported RA flares was mentioned in all medical files, followed by the presence and/or the number of tender joints (76%), the duration of morning stiffness (66%), the number of pain-related nocturnal awakenings (66%) and the C-reactive protein (CRP) value (54%). Teleconsultation led to a clinician intervention in 22/143 patients (15%), representing 51% of patients with self-reported flares (22/43 patients). Therapeutic escalation was necessary in 13 patients and/or face-to-face consultation or day hospitalization were organized for 10 patients. Multivariate analysis identified RA flares (odds ratio [OR] 15.6, 95% CI 3.37-68.28) and CRP values > 10 mg/L (OR 3.32, 95% CI % 1.12-13.27) as the variables independently associated with clinician intervention. Conclusion Our study identified patient-reported RA flares and increased CRP values as 2 red flags in teleconsultation, independently associated with therapeutic modification and/or the need for a rapid face-to-face consultation. These indicators may help clinicians' decision making in teleconsultation.
Coexistence of Anti-Ro52 Antibodies in Anti-MDA5 Antibody–Positive Dermatomyositis Is Highly Associated With Rapidly Progressive Interstitial Lung Disease and Mortality Risk
Authors: Lv Chengyin , You Hanxiao , Xu Lingxiao , Wang Lei , Yuan Fenghong , Li Ju , Wu Min , Zhou Shiliang , Da Zhanyun , Qian Jie , Wei Hua , Yan Wei , Zhou Lei , Wang Yan , Yin Songlou , Zhou Dongmei , Wu Jian , Lu Yan , Su Dinglei , Liu Zhichun , Liu Lin , Ma Longxin , Xu Xiaoyan , Zang Yinshan , Liu Huijie , Ren Tianli , Wang Fang , Zhang Miaojia , Tan Wenfeng 
Published: June 2022

ObjectiveInterstitial lung disease (ILD) is a common extramuscular complication contributing to significant morbidity and mortality in patients with dermatomyositis (DM) who are positive for antimelanoma differentiation–associated gene 5 antibody (anti-MDA5+). We conducted this study to investigate the association of anti-Ro52 antibodies with clinical characteristics and prognosis in patients with anti-MDA5+ DM.MethodsWe assessed a cohort of 246 patients with anti-MDA5+ DM. To calculate hazard ratios and 95% CIs for rapidly progressive ILD (RP-ILD) and death while controlling for potential confounders, variables selected by univariate Cox regression analysis were included in a multivariate Cox regression model with the stepwise forward-selection method. A 2-tailed analysis withP< 0.05 was considered to be statistically significant.ResultsA total of 246 patients with anti-MDA5+ DM were enrolled; 70 patients were male, and the patient group had an average age of 53.1 (12.4) years. Anti-Ro52 was present in 64.2% (158/246) patients. Patients with anti-MDA5+ DM who were positive for anti-Ro52 had a higher rate of RP-ILD (log-rankP< 0.001) and a higher mortality rate (log-rankP= 0.01). For patients with anti-MDA5+ DM who were positive for anti-Ro52, those with a short disease course and high inflammation were at increased risk of RP-ILD and death. The appearance of active rash was an independent protective factor of death.ConclusionAnti-Ro52 antibodies were highly prevalent in patients with anti-MDA5+ DM, and their coexistence correlated with a higher rate of RP-ILD and mortality. Patients with a short disease course, with increased inflammation, and without rash were more likely to have a poor prognosis.