bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bacterial symbionts influence host susceptibility to fenitrothion and imidacloprid in the obligate hematophagous bed bug, Cimex hemipterus
Authors: Soh Li-Shen , Veera Singham G. 
Published: March 2022

AbstractThe use of insecticides remains important in managing pest insects. Over the years, many insects manifested physiological and behavioral modifications resulting in reduced efficacy of insecticides targeted against them. Emerging evidence suggests that bacterial symbionts could modulate susceptibility of host insects against insecticides. Here, we explore the influence of host microbiota in affecting the susceptibility of insect host against different insecticides in the blood-sucking bed bug,Cimex hemipterus. Rifampicin antibiotic treatment resulted in increased susceptibility to fenitrothion and imidacloprid, but not against deltamethrin. Meanwhile, the host fitness parameters measured in the present study were not significantly affected by rifampicin treatment, suggesting the role of bacterial symbionts influencing susceptibility against the insecticides. 16S metagenomics sequencing revealed a drastic shift in the composition of several bacterial taxa following rifampicin treatment. The highly abundant Alphaproteobacteria (Wolbachia > 90%) and Gammaproteobacteria (Yersinia > 6%) in control bed bugs were significantly suppressed and replaced by Actinobacteria, Bacilli, and Betaproteobacteria in the rifampicin treated F1 bed bugs, suggesting possibilities ofWolbachiamediating insecticide susceptibility inC. hemipterus. However, no significant changes in the total esterase, GST, and P450 activities were observed following rifampicin treatment, indicating yet unknown bacterial mechanisms explaining the observed phenomena. Re-inoculation of microbial content from control individuals regained the tolerance of rifampicin treated bed bugs to imidacloprid and fenitrothion. This study provides a foundation for a symbiont-mediated mechanism in influencing insecticide susceptibility that was previously unknown to bed bugs.
Associations of zinc-α-2-glycoprotein with metabolic syndrome and its components among adult Arabs
Authors: Alenad Amal M. , Alkaltham Lamya F. , Sabico Shaun , Khattak Malak N. K. , Wani Kaiser , Al-Daghri Nasser M. , Alokail Majed S. 
Published: March 2022

AbstractEpidemiological studies suggest that the Zinc-α-2-glycoprotein (ZAG) plays significant physiological roles. In this study we investigate whether ZAG could be considered as a clinical biomarker in the diagnosis and prognosis of metabolic syndrome (MetS) in Saudi population. As such insights urgently required for management of MetS. Thus, we have determined serum levels of ZAG in patients with MetS and normal individuals. We have also assessed the correlation between ZAG and different components of MetS. In this case–control study, clinical information of 200 Saudi male and female subjects (age range 30–65) with MetS (n = 100) and healthy controls (n = 100) were extracted from the database of the Chair of Biomarkers of Chronic Disease (CBCD) in King Saud University (KSU), Riyadh, Saudi Arabia. MetS was screened according to NCEP ATP III criteria (National Cholesterol Education Program Adult Treatment Panel III). Fasting glucose and lipid profile levels were measured using Konelab. Serum TNF-α, IL- 6, CRP and ZAG levels were measured using commercially available assays. There was an age-dependent significant increase in ZAG level among MetS subjects than controls (43.8 ± 19.5 vs 48.1 ± 14.8; P = 0.04). A significant inverse correlation between ZAG and serum HDL-cholesterol (r = − 0.20, P < 0.05) was observed. Whereas, triglycerides (r = 0.25, P < 0.01), waist circumference (WHR) (r = 0.17, P < 0.05) and CRP (r = 0.24, P < 0.01) were all significantly and positively associated with ZAG. Circulating ZAG is associated with MetS in an age-dependent manner. Serum ZAG is a potential biomarker for MetS.
Extensive spatial impacts of oyster reefs on an intertidal mudflat community via predator facilitation
Authors: Reddin Carl J. , Decottignies Priscilla , Bacouillard Lise , Barillé Laurent , Dubois Stanislas F. , Echappé Caroline , Gernez Pierre , Jesus Bruno , Méléder Vona , Nätscher Paulina S. , Turpin Vincent , Zeppilli Daniela , Zwerschke Nadescha , Brind’Amour Anik , Cognie Bruno 
Published: March 2022

AbstractHabitat engineers make strong and far-reaching imprints on ecosystem processes. In intertidal mudflats, the dominant primary producer, microphytobenthos (MPB), often forms high biomass patches around oyster reefs. We evaluate multiple hypotheses linking MPB with oyster reefs, including oyster biodeposition, meiofaunal grazing, and abiotic factors, aiming to help predict effects of reef removal or proliferation. We quantify spatial patterns of an Atlantic mudflat community and its environment around two large Crassostrea reefs before experimentally sacrificing one reef via burning. MPB biomass was enriched surrounding living oyster reefs although infaunal biomass and individual sizes were low. Structural equation modelling best supported the hypothesis that crab predation intensity, which decayed with distance from the reefs, locally freed MPB from grazing. Our results suggest that Crassostrea reef expansion may enrich local MPB patches and redirect trophic energy flows away from mudflat infauna, with potential implications for the sustainability of local fisheries and bird conservation.
Influenza A virus diffusion through mucus gel networks
Authors: Kaler Logan , Iverson Ethan , Bader Shahed , Song Daniel , Scull Margaret A. , Duncan Gregg A. 
Published: March 2022

AbstractMucus in the lung plays an essential role as a barrier to infection by viral pathogens such as influenza A virus (IAV). Previous work determined mucin-associated sialic acid acts as a decoy receptor for IAV hemagglutinin (HA) binding and the sialic-acid cleaving enzyme, neuraminidase (NA), facilitates virus passage through mucus. However, it has yet to be fully addressed how the physical structure of the mucus gel influences its barrier function and its ability to trap viruses via glycan mediated interactions to prevent infection. To address this, IAV and nanoparticle diffusion in human airway mucus and mucin-based hydrogels is quantified using fluorescence video microscopy. We find the mobility of IAV in mucus is significantly influenced by the mesh structure of the gel and in contrast to prior reports, these effects likely influence virus passage through mucus gels to a greater extent than HA and NA activity. In addition, an analytical approach is developed to estimate the binding affinity of IAV to the mucus meshwork, yielding dissociation constants in the mM range, indicative of weak IAV-mucus binding. Our results provide important insights on how the adhesive and physical barrier properties of mucus influence the dissemination of IAV within the lung microenvironment.
Porcine intraepithelial lymphocytes undergo migration and produce an antiviral response following intestinal virus infection
Authors: Li Yuchen , Ma Yichao , Jin Yuxin , Peng Xuebin , Wang Xiuyu , Zhang Penghao , Liu Peng , Liang Chun , Yang Qian 
Published: March 2022

AbstractThe location of intraepithelial lymphocytes (IELs) between epithelial cells provide a first line of immune defense against enteric infection. It is assumed that IELs migrate only along the basement membrane or into the lateral intercellular space (LIS) between epithelial cells. Here, we identify a unique transepithelial migration of porcine IELs as they move to the free surface of the intestinal epithelia. The major causative agent of neonatal diarrhea in piglets, porcine epidemic diarrhea virus (PEDV), increases the number of IELs entering the LIS and free surface of the intestinal epithelia, driven by chemokine CCL2 secreted from virus-infected intestinal epithelial cells. Remarkably, only virus pre-activated IELs inhibits PEDV infection and their antiviral activity depends on the further activation by virus-infected cells. Although high levels of perforin is detected in the co-culture system, the antiviral function of activated IELs is mainly mediated by IFN-γ secretion inducing robust antiviral response in virus-infected cells. Our results uncover a unique migratory behavior of porcine IELs as well as their protective role in the defense against intestinal infection.
Study Protocol: Type 1 Hybrid Effectiveness–Implementation Trial of a Behavioral Parent Training Intervention for Parents of Young Children Who Are Deaf or Hard of Hearing
Authors: Studts Christina R. , Jacobs Julie A. , Bush Matthew L. , Lowman Joneen , Creel Liza M. , Westgate Philip M. 
Published: March 2022

Purpose:
Children who are deaf or hard of hearing (DHH) and who use hearing aids or cochlear implants are more likely than their peers with typical hearing to exhibit behavior problems. Although multiple evidence-based interventions for child behavior problems exist, they are rarely delivered to children who are DHH, and no rigorous randomized controlled trials have been conducted to determine their effects with this population. This protocol describes a study aiming to test the effectiveness of an evidence-based behavioral parent training intervention adapted for parents of young children who are DHH and simultaneously to assess key implementation outcomes and multilevel contextual factors influencing implementation.

Method:
The protocol for a Type 1 hybrid effectiveness–implementation trial of a behavioral parent training intervention for parents of young children who are DHH is presented, including details of the study design, participants, assessments, and analyses. Using a stakeholder-engaged, mixed-methods approach, we will test the effects of the intervention versus treatment as usual on parenting behaviors, child behaviors, and a range of secondary effectiveness outcomes, including adherence to using hearing aids and cochlear implants as well as measures of child speech and language. We will assess the acceptability, feasibility, fidelity, and costs of the intervention from the perspectives of peer coaches who deliver the intervention, hearing health care clinicians (including audiologists and speech-language pathologists), and administrators of programs serving young children who are DHH.

Conclusions:
Results of this trial will inform future efforts to close the gap between prevalence of behavioral problems in young children who are DHH and access to and use of evidence-based interventions to prevent and treat them. If effective, this intervention could be widely implemented using strategies informed by the findings of this study to benefit young children who are DHH and followed in hearing health care and their families.
Modeling overcontact binaries
Authors: Fabry M. , Marchant P. , Sana H. 
Published: March 2022

Context. In the realm of massive stars, strong binary interactions are commonplace. One extreme case is that of overcontact systems, which are expected to be part of the evolution of all stars evolving towards a merger and hypothesized as playing a role in the formation of binary black holes. However, important simplifications are made to model the evolution of overcontact binaries. The deformation from tidal forces is almost always put aside, and even rotation is frequently ignored in such models. Yet, both observations and theory have shown that overcontact stars are tidally deformed to a great extent, leaving a potentially important effect on the outer layers unaccounted for in models. Furthermore, in eclipsing binaries where radii can be determined to high precision, the question of how large the effect of tidal deformation is on the inferred properties of stellar models is still uncertain.
Aims. We aim to consistently model overcontact binary stars in a one-dimensional (1D) stellar evolution code. To that end, we developed the required methodology to represent tidally distorted stars in 1D evolution codes.
Methods. Using numerical methods, we computed the structure correction factors to the 1D spherical stellar structure equations of hydrostatic equilibrium and radiative energy transfer due to the binary Roche potential. We then compared them to existing results and the structure corrections of single, rotating stars. We implemented the new structure correction factors in the stellar evolution code MESA and explored several case studies. We compared the differences between our simulations: when no rotation is included, when we treat rotation using single star corrections (only accounting for centrifugal deformation), or when we use tidal deformation.
Results. We find that ignoring rotation in deformed detached eclipsing binaries can produce a radius discrepancy of up to 5%. The difference between tidal and single star centrifugal distortion models is more benign at 1%, showing that single rotating star models are a suitable approximation of tidally deformed stars in a binary system. In overcontact configurations, we find a similar 5% variation in surface properties as a result of tidal distortion with respect to non-rotating models, showing that it is inappropriate to model binary stars filling their Roche lobe significantly as non-rotating.
Evaluation of science advice during the COVID-19 pandemic in Sweden
Authors: Brusselaers Nele , Steadson David , Bjorklund Kelly , Breland Sofia , Stilhoff Sörensen Jens , Ewing Andrew , Bergmann Sigurd , Steineck Gunnar 
Published: March 2022

AbstractSweden was well equipped to prevent the pandemic of COVID-19 from becoming serious. Over 280 years of collaboration between political bodies, authorities, and the scientific community had yielded many successes in preventive medicine. Sweden’s population is literate and has a high level of trust in authorities and those in power. During 2020, however, Sweden had ten times higher COVID-19 death rates compared with neighbouring Norway. In this report, we try to understand why, using a narrative approach to evaluate the Swedish COVID-19 policy and the role of scientific evidence and integrity. We argue that that scientific methodology was not followed by the major figures in the acting authorities—or the responsible politicians—with alternative narratives being considered as valid, resulting in arbitrary policy decisions. In 2014, the Public Health Agency, after 5 years of rearrangement, merged with the Institute for Infectious Disease Control, with six professors leaving between 2010 and 2012 going to the Karolinska Institute. With this setup, the authority lost scientific expertise. The Swedish pandemic strategy seemed targeted towards “natural” herd-immunity and avoiding a societal shutdown. The Public Health Agency labelled advice from national scientists and international authorities as extreme positions, resulting in media and political bodies to accept their own policy instead. The Swedish people were kept in ignorance of basic facts such as the airborne SARS-CoV-2 transmission, that asymptomatic individuals can be contagious and that face masks protect both the carrier and others. Mandatory legislation was seldom used; recommendations relying upon personal responsibility and without any sanctions were the norm. Many elderly people were administered morphine instead of oxygen despite available supplies, effectively ending their lives. If Sweden wants to do better in future pandemics, the scientific method must be re-established, not least within the Public Health Agency. It would likely make a large difference if a separate, independent Institute for Infectious Disease Control is recreated. We recommend Sweden begins a self-critical process about its political culture and the lack of accountability of decision-makers to avoid future failures, as occurred with the COVID-19 pandemic.
Mechanical cloak via data-driven aperiodic metamaterial design
Authors: Wang Liwei , Boddapati Jagannadh , Liu Ke , Zhu Ping , Daraio Chiara , Chen Wei 
Published: March 2022

Significance
An invisibility cloak to conceal objects from an outside observer has long been a subject of interest in metamaterial design. While cloaks have been manufactured for optical, thermal, and electric fields, limited progress has been made for mechanical cloaks. Most existing designs rely on mapping-based methods, which have so far been limited to special base cells and a narrow selection of voids with simple shapes. In this study, we develop a fundamentally different approach by exploiting data-driven designs to offer timely, customized solutions to mechanical cloaking that were previously difficult to obtain. Through simulations and experimental validations, we show that excellent cloaking performance can be achieved for various boundary conditions, shapes of voids, base cells, and even multiple voids.
Study of correlations between seismic data and Virgo’s gravitational-wave detector data
Authors: Figura Przemysław , Bulik Tomasz , Harms Jan , Calloni Enrico , Errico Luciano , De Rosa Rosario , Gennai Alberto 
Published: March 2022

Abstract
It is expected that noise produced by terrestrial gravity fluctuations will start to limit the sensitivity of the ground-based, gravitational-wave detector Virgo in coming observation runs. A system is under preparation at Virgo to cancel this noise, also known as Newtonian noise. This Newtonian noise cancelation system requires the deployment of seismometer arrays inside the Virgo buildings. Crucial for the design of such a system is a detailed understanding of correlations between ground vibrations and Virgo’s gravitational waves detector data. In this article, we present first analyses of such correlations observed with a tiltmeter. We find that revealed correlations are stronger than predicted by possible pure gravitational coupling, which is pointing towards additional coupling mechanisms. These findings might impact the design of the Newtonian noise cancelation system if the additional couplings cannot be mitigated.
Extreme ℓ-boson stars
Authors: Alcubierre Miguel , Barranco Juan , Bernal Argelia , Degollado Juan Carlos , Diez-Tejedor Alberto , Jaramillo Víctor , Megevand Miguel , Núñez Darío , Sarbach Olivier 
Published: March 2022

Abstract
A new class of complex scalar field objects, which generalize the well known boson stars, was recently found as solutions to the Einstein–Klein–Gordon system. The generalization consists in incorporating some of the effects of angular momentum, while still maintaining the spacetime’s spherical symmetry. These new solutions depend on an (integer) angular parameter ℓ, and hence were named ℓ-boson stars. Like the standard ℓ = 0 boson stars these configurations admit a stable branch in the solution space; however, contrary to them they have a morphology that presents a shell-like structure with a ‘hole’ in the internal region. In this article we perform a thorough exploration of the parameter space, concentrating particularly on the extreme cases with large values of ℓ. We show that the shells grow in size with the angular parameter, doing so linearly for large values, with the size growing faster than the thickness. Their mass also increases with ℓ, but in such a way that their compactness, while also growing monotonically, converges to a finite value corresponding to about one half of the Buchdahl limit for stable configurations. Furthermore, we show that ℓ-boson stars can be highly anisotropic, with the radial pressure diminishing relative to the tangential pressure for large ℓ, reducing asymptotically to zero, and with the maximum density also approaching zero. We show that these properties can be understood by analyzing the asymptotic limit ℓ → ∞ of the field equations and their solutions. We also analyze the existence and characteristics of both timelike and null circular orbits, especially for very compact solutions.
The momentum constraint equation in parameterised post-Newtonian cosmology
Authors: Anton Theodore , Clifton Timothy 
Published: March 2022

Abstract
We derive a theory-independent version of the momentum constraint equation for use in cosmology, as a part of the parameterised post-Newtonian cosmology framework. Our equations are constructed by adapting the corresponding quantities from formalisms constructed for testing and constraining gravity in isolated astrophysical systems, thereby extending the domain of applicability of these approaches up to cosmological scales. Our parameterised equations include both scalar and divergenceless-vector gravitational potentials, and can be applied to both conservative and non-conservative theories of gravity. They can also be used to describe the gravitational fields of both non-linear structures and super-horizon perturbations. We apply the parameterised equations we propose to quintessence models of dark energy, as well as scalar-tensor and vector-tensor theories of gravity. We find them to work well in each case. Our equations are highly compact, and are intended to be useful for constraining gravity in a theory-independent fashion in cosmology.
Electronic and optical properties of Janus black arsenic-phosphorus AsP quantum dots under magnetic field
Authors: Yan Xuefei , Ke Qingqing , Cai Yongqing 
Published: March 2022

Abstract
By utilizing the tight-binding method, the electronic spectrum and states distribution of square Janus monolayer black arsenic phosphorus (b-AsP) quantum dots (QDs) in the presence of a perpendicular magnetic field are explored. Strong in-gap states of b-AsP QDs, whose probability densities are distributed on the armchair boundary (armchair edge states) appear in the energy gap of host perfect two-dimensional b-AsP. The corresponding energy levels of the armchair edge states can degenerate to the Landu energy levels upon applying a perpendicular magnetic field. When an in-plane polarized light is introduced, due to the presence of armchair edge states, the edge-to-edge transitions are mainly induced from the armchair edge (hole) states to zigzag edge (electron) states. The optical absorption undergoes blue shift as a function of the magnetic field. Our work suggests tunable optical properties via modulating the armchair edge states of a b-AsP QD and provides a theoretical basis for the design of b-AsP-based optoelectronic devices.
Twisted graphene stabilized by organic linkers pillaring
Authors: Liu Chengyuan , Li Wenlian , Xue Lin , Hao Yuying 
Published: March 2022

Abstract
Twisted graphene, including magic angle graphene, has attracted extensive attentions for its novel properties recently. However, twisted graphene is intrinsically unstable and this will obstruct their application in practice, especially for twisted nano graphene. The twist angles between adjacent layers will change spontaneously. This relaxation process will be accelerated under heat and strain. To solve this problem, we propose a strategy of pillaring twisted graphene by organic linkers in theory. The necessity and feasibility of this strategy is proved by numerical calculation.