bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and genetic spectrum of hereditary spastic paraplegia in Chinese children
Authors: Wang Jiaping , Fang Fang , Ding Changhong , Li Jiuwei , Wu Yun , Zhang Weihua , Bao Xinhua , Lv Junlan , Wang Xiaohui , Ren Xiaotun ,   Paediatric Neurology Study Group
Published: September 2022

AbstractAimTo explore the clinical and genetic spectrum of hereditary spastic paraplegia (HSP) in Chinese children.MethodThis retrospective study was conducted between January 2014 and October 2021 in children clinically diagnosed with either pure HSP (pHSP) or complex HSP (cHSP).ResultsWe investigated 45 children (32 males, 13 females; mean age [SD] at symptom onset 4 years [7 months]). clinically diagnosed with HSP and identified genetic causes in 35 patients. Most patients with autosomal dominant HSP had pHSP (16/18), whereas most patients with autosomal recessive HSP tended to have cHSP (14/16). SPG11 was the most common autosomal recessive subtype, followed by FA2H/SPG35, whereas SPAST/SPG4 was the most frequent cause of autosomal dominant HSP. Two patients with CPT1C mutations presented with a complex phenotype. Meanwhile, 10 patients were found to have likely pathogenic variants/variants of uncertain clinical significance in six genes related to HSP.InterpretationSPG11 and SPG4 were the most frequent subtypes in Chinese children with autosomal recessive HSP and autosomal dominant HSP. However, the prevalence of SPG4 was much lower than that in adults, which might be explained by the late onset of the disease. On the other hand, FA2H/SPG35 was common in our cohort, while it contributed to only a small proportion of adult cases, which might be explained by its rapid progression and early death in some patients. We also expanded the genetic and clinical spectra of SPG73.
Child neurology telemedicine: Analyzing 14 820 patient encounters during the first year of the COVID‐19 pandemic
Authors: Kaufman Michael C. , Xian Julie , Galer Peter D. , Parthasarathy Shridhar , Gonzalez Alexander K. , McKee Jillian L. , Prelack Marisa S. , Fitzgerald Mark P. , Helbig Ingo ,   CHOP Neuroscience Center ‐ Telemedicine Research Group
Published: September 2022

AbstractAimTo determine the long‐term impact of telemedicine in child neurology care during the COVID‐19 pandemic and with the reopening of outpatient clinics.MethodWe performed an observational cohort study of 34 837 in‐person visits and 14 820 telemedicine outpatient visits across 26 399 individuals. We assessed differences in care across visit types, time‐period observed, time between follow‐ups, patient portal activation rates, and demographic factors.ResultsWe observed a higher proportion of telemedicine for epilepsy (International Classification of Diseases, 10th Revision G40: odds ratio [OR] 1.4, 95% confidence interval [CI] 1.3–1.5) and a lower proportion for movement disorders (G25: OR 0.7, 95% CI 0.6–0.8; R25: OR 0.7, 95% CI 0.6–0.9) relative to in‐person visits. Infants were more likely to be seen in‐person after reopening clinics than by telemedicine (OR 1.6, 95% CI 1.5–1.8) as were individuals with neuromuscular disorders (OR 1.6, 95% CI 1.5–1.7). Self‐reported racial and ethnic minority populations and those with highest social vulnerability had lower telemedicine participation rates (OR 0.8, 95% CI 0.8–0.8; OR 0.7, 95% CI 0.7–0.8).InterpretationTelemedicine continued to be utilized even once in‐person clinics were available. Pediatric epilepsy care can often be performed using telemedicine while young patients with neuromuscular disorders often require in‐person assessment. Prominent barriers for socially vulnerable families and racial and ethnic minorities persist.
Which attributes of fishing opportunities are linked to sustainable fishing?
Authors: Oostdijk Maartje , Carpenter Griffin 
Published: September 2022

AbstractTo prevent the overfishing of marine fish populations, governments often limit fishing access through the allocation of fishing opportunities. While some studies have linked particular systems of fishing opportunities to sustainable outcomes (particularly individual transferable quota), it remains unclear whether it is the use of exclusive access (individual allocation), the use of a market (tradability), the duration of this access or the quota limits themselves that drive the sustainable outcomes. To determine which attributes of fishing opportunities are associated with sustainable fishing, we developed a novel method to systematically classify how fishing opportunities are allocated for 443 global fish stocks from 1990 to 2018 to produce the longest and most comprehensive dataset and longitudinal study of its kind. Our results revealed that quota limits and individual allocation are linked to a reduced probability of overfishing, with the most robust result for quota limits. No attributes were robustly linked to a reduced probability of overfished biomass. Whereas some previous studies have found that systems with market‐based features or strong property rights (i.e. a long duration) were linked to sustainable fishing, these benefits were found to be small or not significant once proper controls for other system attributes were introduced. These results highlight the importance of considering all attributes of institutional design in the governance of common pool resources.
Theory generation from literature reviews: A methodological guidance
Authors: Tsiotsou Rodoula H. , Koles Bernadett , Paul Justin , Loureiro Sandra Maria Correia 
Published: September 2022

AbstractThis article aims to assist researchers in navigating the path to theory creation by investigating how they might build theory through literature reviews. In particular, we propose and elaborate upon the Theory Generation from Literature Review (TGLR) process, capturing different methods and techniques to be applied depending on the level of development and saturation characterizing the focal area of inquiry. In the second part of the article, we briefly present the 21 articles conducting systematic literature reviews on consumer research topics selected for this special issue in IJCS.
Effects of ageing and salt concentrations on metabolite profiles and their correlation with consumer acceptance in Korean traditional doenjang (fermented soybean paste)
Authors: Kim Sang Sook , Heo JeongAe , Kwak Han Sub 
Published: September 2022

SummaryThe effects of brine concentration (8%, 12%, 16% and 20%) and ageing (0 and 12 months) of Korean traditional doenjang (fermented soybean paste) on metabolite profiles and their relationship with consumer acceptance were investigated. Using ultra‐performance liquid chromatography‐quadrupole‐time‐of‐flight mass spectrometry and gas chromatography–mass spectrometry, we identified 26 and 31 metabolites, respectively. After 12 months of ageing, the relative amounts of metabolites increased owing to the degradation of soy protein into peptides and amino acids. Functional metabolites, such as isoflavones and gamma‐aminobutyric acid, were higher in the lower salt‐containing and longer‐aged samples. Generally, lowering the salt content of doenjang results in the production of more functional metabolites. In contrast, the consumer acceptance of low‐salt‐containing samples made with 8% brine showed significantly lower acceptance ratings than the regular doenjang samples due to over‐fermentation, which generated high lactic acid and no sugar in the sample. The partial least significant regression analysis between metabolites and consumer acceptance ratings suggested that amino acids – alanine, valine, isoleucine, proline, serine, threonine, hydroxyproline, glutamic acid and phenylalanine – were key metabolites that highly correlated with consumer acceptance of doenjang. These metabolites can be adopted as indicators of highly acceptable doenjang products.
The typology of vocational education and training cooperation between Germany and China
Authors: Zhu Shan , Meyer Wolfgang , Röhrig Selina 
Published: September 2022

AbstractGermany and China have been engaged in a wide range of vocational education and training (VET) cooperation activities since the 1980s. To clarify what organizations have been involved and what project types exist within VET cooperation, a semistructured survey had been conducted for collecting data. By this approach, 99 VET project profiles with 258 organizations related were detected. To analyse these projects and organizations, the ‘general key factor model of sustainability’ is used to structure the analysis framework. In this framework, ‘cooperation type’, ‘content type’ and ‘project duration’ were considered as the three fundamental criteria for further categorization. On this basis, seven cooperation types were created by the organizations involved, three content types were established by the goal of the project and three project duration were distinguished by the time planned for the project. The result shows that governmental organizations are the main actors who play a major role in the Sino‐German VET cooperation. However, numerically, German private organizations participated more in VET cooperation rather than Chinese private organizations. Civil social organizations show no significant function. Meanwhile, different cooperation types show different projects' emphasis: Type G (Governmental) projects focus on building or promoting on the organization level; Type G + P (Governmental + Private) projects tend to objectives on the individual and system level; Type G + C (Governmental + Civil) projects occur more often at an individual level; Type G + P + C (Governmental + Private + Civil) projects tend to pursue goals on organizational or system level.
Maternal predictors of children's mental health in low‐income families: A structural equation model
Authors: Kwon Boram , Lee Il‐Hyun , Lee Gyungjoo 
Published: September 2022

AbstractLow‐income populations are particularly susceptible to mental health problems, and the susceptibilities of family members may be interconnected. In particular, maternal factors are known to be linked to their children's outcomes. This study aims to investigate how maternal cognition, depression, and the mother–child relationship, as well as children's cognition, predict the mental health of children in low‐income families. Pairs of mothers and children from families receiving governmental assistance were surveyed between January 2018 and March 2019. Korean versions of the following instruments were used: Strengths and Difficulties Questionnaire (children's mental health problems), Cognitive Triad Inventory for Children (children's cognition), Kerns' Security Scale (mother–child relationship), Center for Epidemiologic Studies Depression Scale (maternal depression), and Automatic Thoughts Questionnaire–Negative (maternal cognition). A structural equation model was used to examine how maternal cognition, depression, the mother–child relationship, and children's cognition predict children's mental health. Maternal negative cognition and depression mediated by the children's relationships with their mothers negatively predicted their cognition and mental health problems. Enhancing maternal mental health and a mother–child relationship can help improve positive cognition and mental health of children from low‐income families.
Precariousness during an ongoing crisis. Cultural workers and the corona pandemic
Authors: Elstad Beate , Døving Erik , Jansson Dag 
Published: September 2022

AbstractThis study examines precariousness among cultural workers during an ongoing crisis. A survey of Norway's largest trade union for performing artists 1 year into the pandemic shows that precariousness before the pandemic was amplified during the crisis. Lack of economic buffer and social benefits rendered economic insecurity most burdensome for those with precarious work arrangements. For future crises, we suggest that the authorities need to develop better targeted economic compensations for labour with precarious work arrangements.
Do as You Say, or I Will: Retail signal congruency inbuy‐online‐pickup‐in‐storeand negativeword‐of‐mouth
Authors: Jin Yao “Henry” , Ueltschy Murfield Monique L. , Bock Dora E. 
Published: September 2022

AbstractBuy‐online‐pickup‐instore (BOPIS) services have become an increasingly important part of a retailer's omnichannel strategy. When service failures (e.g., stock‐out) occur, consumers may resort to negative word‐ofmouth (NWOM) to share their evaluation of the retailer's BOPIS service. While a retailer's service recovery policies (e.g., cross‐channel substitution) may help to fulfill its service intent, the extent to which these two signals can improve consumer satisfaction and diminish their NWOM intent remains unknown. Drawing from both service recovery literature and signaling theory, we conducted a series of five experiments and find that the intradimensional congruity of the signal set communicated by the retailer during its BOPIS service process depends on both its operational capability and the consumer's own predilection regarding the product category. These insights collectively indicate that while a retailer's operations need to support service policies to provide a congruous BOPIS service process, substitution policies offered to consumers during the transaction need to consider the extent to which a consumer's purchase decision is hedonic or utilitarian. In turn, this finding suggests that a retailer's category management needs to consider BOPIS substitution in terms of both product assortment and inventory policies.
Effects of food components and processing parameters on plant‐based meat texture formation and evaluation methods
Authors: Xia Yujie , Qian Jing , Zhao Yicheng , Zheng Bin , Wei Kaidong , Peng Binbin , Yuan Jian , Xing Changrui , Yan Wenjing 
Published: September 2022

AbstractMeat is the main source of protein nutrition for humans. However, given the increasing population and environmental pressure, a shortage of meat is expected in the future. The preparation of plant‐based (meat) products using existing processing methods represents a breakthrough to solve the shortage of traditional animal meat in the future, and texture is a key issue determining whether plant‐based (meat) products can replace traditional animal meat. Therefore, this review highlights recent progress in the texture of plant‐based (meat) products. First, the texture changes in plant‐based (meat) products were reviewed based on components (proteins, starch, lipids, food additives) and processing methods (processing factors, instrumental factors). Then, the current methods used to analyze the texture of plant‐based (meat) products were summarized based on sensory evaluation and instrumental analysis (mechanical analysis, spectral analysis, and image analysis). Finally, this review outlined methods to improve the texture quality of plant‐based (meat) products and analytical evaluation methods and provided an outlook on future research priorities.
Association between asymptomatic infections and linear growth in 18–24‐month‐old Malawian children
Authors: Luoma Juho , Adubra Laura , Ashorn Per , Ashorn Ulla , Bendabenda Jaden , Dewey Kathryn G. , Hallamaa Lotta , Coghlan Ryan , Horton William A. , Hyöty Heikki , Kortekangas Emma , Lehto Kirsi‐Maarit , Maleta Kenneth , Matchado Andrew , Nkhoma Minyanga , Oikarinen Sami , Parkkila Seppo , Purmonen Sami , Fan Yue‐Mei 
Published: September 2022

AbstractInadequate diet and frequent symptomatic infections are considered major causes of growth stunting in low‐income countries, but interventions targeting these risk factors have achieved limited success. Asymptomatic infections can restrict growth, but little is known about their role in global stunting prevalence. We investigated factors related to length‐for‐age Z‐score (LAZ) at 24 months by constructing an interconnected network of various infections, biomarkers of inflammation (as assessed by alpha‐1‐acid glycoprotein [AGP]), and growth (insulin‐like growth factor 1 [IGF‐1] and collagen X biomarker [CXM]) at 18 months, as well as other children, maternal, and household level factors. Among 604 children, there was a continuous decline in mean LAZ and increased mean length deficit from birth to 24 months. At 18 months of age, the percentage of asymptomatic children who carried each pathogen was: 84.5% enterovirus, 15.5% parechovirus, 7.7% norovirus, 4.6% rhinovirus, 0.6% rotavirus, 69.6% Campylobacter, 53.8% Giardia lamblia, 11.9% malaria parasites, 10.2% Shigella, and 2.7% Cryptosporidium. The mean plasma IGF‐1 concentration was 12.5 ng/ml and 68% of the children had systemic inflammation (plasma AGP concentration >1 g/L). Shigella infection was associated with lower LAZ at 24 months through both direct and indirect pathways, whereas enterovirus, norovirus, Campylobacter, Cryptosporidium, and malaria infections were associated with lower LAZ at 24 months indirectly, predominantly through increased systemic inflammation and reduced plasma IGF‐1 and CXM concentration at 18 months.
Linked selection, differential introgression and recombination rate variation promote heterogeneous divergence in a pair of yellow croakers
Authors: Wang Le , Liu Shufang , Yang Yang , Meng Zining , Zhuang Zhimeng 
Published: September 2022

AbstractUnderstanding the mechanisms underlying heterogeneous genomic divergence is of particular interest in evolutionary biology. Highly differentiated genomic regions, known as genomic islands, often evolve between diverging lineages. These genomic islands may be related to selection promoting adaptation or reproductive isolation. Based on whole genome assembly and genome‐wide RAD sequencing in a pair of yellow croakers (genus: Larimichthys), we investigated the evolutionary processes shaping genomic landscapes of divergence. Demographic modelling indicated that the two species diverged following a secondary contact scenario, where differential introgression and linked selection were suggested to be involved in heterogeneous genomic divergence. We identified reduced recombination rate in genomic islands and a relatively good conservation of both genetic diversity and recombination landscapes between species, which highlight the roles of linked selection and recombination rate variation in promoting heterogeneous divergence in the common ancestral lineage of the two species. In addition, we found a positive correlation between differentiation (FST) and absolute sequence divergence (Dxy), and elevated Dxy in genomic islands, indicating that the genomic landscape of divergence was not shaped by linked selection alone. Restricted gene flow in highly differentiated regions has probably remodelled the landscape of heterogeneous genomic divergence. This study highlights that highly differentiated genomic regions can also arise from a combination of linked selection and differential gene flow in interaction with varying recombination rates.
Induction therapy with high‐dose fluconazole plus flucytosine for human immunodeficiency virus‐uninfected cryptococcal meningitis patients: Feasible or not?
Authors: Zhao Hua‐Zhen , Cheng Jia‐Hui , Zhou Ling‐Hong , Luo Yu , Zhu Rong‐Sheng , Jiang Ying‐Kui , Wang Xuan , Zhu Li‐Ping 
Published: September 2022

AbstractBackgroundCryptococcal meningitis (CM) is increasingly recognised in human immunodeficiency virus (HIV)‐uninfected patients with high mortality. The efficacy and safety profiles of induction therapy with high‐dose fluconazole plus flucytosine remain unclear.MethodsHIV‐uninfected CM patients who received high‐dose fluconazole (800 mg/d) for initial therapy in Huashan Hospital were included in this retrospective study from January 2013 to December 2018. Efficacy and safety of initial therapy, clinical outcomes and risk factors were evaluated.ResultsTwenty‐seven (71.1%) patients who received high‐dose fluconazole with flucytosine combination therapy and 11 (28.9%) having fluconazole alone for induction therapy were included. With a median duration of 42 days (IQR, 28–86), the successful response rate of initial therapy was 76.3% (29/38), while adverse drug reactions occurred in 14 patients (36.8%). The rate of persistently positive cerebrospinal fluid (CSF) culture results was 30.6% at 2 weeks, which was significantly associated with CSF CrAg titre >1:1280 (OR 9.56; 95% CI 1.40–103.65; p = .010) and CSF culture of Cryptococcus >3.9 log10CFU/ml (OR 19.20; 95% CI 1.60–920.54; p = .011), and decreased to 8.6% at 4 weeks. One‐year mortality was 15.8% (6/38), and low serum albumin (35 g/L) was found as an independent risk factor for 1‐year mortality (HR 6.31; 95% CI 1.150–34.632; p = .034).ConclusionsInduction therapy with high‐dose fluconazole (800 mg/d), combined with flucytosine, effectively treated HIV‐uninfected CM and was well tolerated. Long‐term fluconazole treatment with continued monitoring is beneficial for patients with persistent infection.
Global patterns of prescription pain medication usage in disorders of gut–brain interactions
Authors: Luo Yuying , Camey Suzi A. , Bangdiwala Shrikant I. , Palsson Olafur S. , Sperber Ami D. , Keefer Laurie A. 
Published: September 2022

AbstractBackgroundForty percent of individuals globally meet Rome IV criteria for a disorder of gut–brain interaction (DGBI). The global burden of pain across these disorders has not been characterized.MethodsOur study included 54,127 respondents from the 26 Internet survey countries. Prescription pain medication usage was selected as the proxy for pain. The associations between prescription pain medications and the environmental, sociodemographic, psychosocial, and DGBI diagnosis variables were investigated using the multivariate generalized robust Poisson regression model.Key ResultsRespondents with DGBI used prescription pain medications at higher rates than those without a DGBI diagnosis with pooled prevalence rate of 14.8% (95% confidence interval [CI], 14.4–15.3%), varying by country from 6.8% to 25.7%. The pooled prevalence ratio of prescription pain medication usage in respondents with and without DGBI was 2.2 (95% CI: 2.1–2.4). Factors associated with higher prevalence of pain medication usage among respondents with a DGBI diagnosis included living in a small community, increased anxiety, depression or somatization, increased stress concern or embarrassment about bowel functioning and having more than one anatomic DGBI diagnosis.Conclusion14.8% of patients globally with at least one diagnosis of DGBI were on prescription pain medications with wide geographic variation, about twice as many as their counterparts without a diagnosis of DGBI. Environmental, sociodemographic, and individual factors may influence clinicians to consider personalized, multimodal approaches to address pain in patients with DGBI.