bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early recurrence factors in patients with stage III non‐small cell lung cancer treated with concurrent chemoradiotherapy
Authors: Takahara Yutaka , Tanaka Takuya , Ishige Yoko , Shionoya Ikuyo , Yamamura Kouichi , Sakuma Takashi , Nishiki Kazuaki , Nakase Keisuke , Nojiri Masafumi , Kato Ryo , Shinomiya Shohei , Oikawa Taku , Mizuno Shiro 
Published: October 2022

AbstractBackgroundThe clinical characteristics and risk factors for cancer recurrence have not been well evaluated regarding early recurrence in patients with unresectable locally advanced non‐small cell lung cancer (LA‐NSCLC) who receive concurrent chemoradiotherapy (CRT).The aim of this study was to determine the clinical characteristics and risk factors of patients with stage III unresectable LA‐NSCLC treated with CRT who developed early recurrence.MethodsWe retrospectively reviewed the clinical records of 46 patients diagnosed with stage III unresectable LA‐NSCLC treated with CRT at our center between July 2012 and July 2021. A tumor proportion score (TPS) < 50% was defined as “low expression” and a TPS > 50% was defined as “high expression.”ResultsA total of 17 (37.0%) patients had a confirmed recurrence within 1 year of treatment. More patients had a lower body mass index in the early recurrence group than in the later recurrence group (p = 0.038). A higher number of patients in the late recurrence group underwent surgery after CRT (p = 0.036). Patients with a higher TPS were more likely to experience late recurrence than early recurrence (p = 0.001), whereas more patients with stage N3 disease were in the early recurrence group (p = 0.011). Multivariate analysis identified lower TPS expression as an independent risk factor for early recurrence after CRT. Overall survival was prolonged in the late recurrence group (p < 0.001).ConclusionsA lower TPS may be a predictor of early recurrence after CRT in patients with LA‐NSCLC. These patients should be closely monitored for post‐treatment recurrence.
Gender differences in cocaine‐induced hyperactivity and dopamine transporter trafficking to the plasma membrane
Authors: Deng Jing , Zheng Xirong , Shang Linyue , Zhan Chang‐Guo , Zheng Fang 
Published: October 2022

AbstractAs well known, cocaine induces stimulant effects and dopamine transporter (DAT) trafficking to the plasma membrane of dopaminergic neurons. In the present study, we examined cocaine‐induced hyperactivity along with cocaine‐induced DAT trafficking and the recovery rate of the dopaminergic system in female rats in comparison with male rats, demonstrating interesting gender differences. Female rats are initially more sensitive to cocaine than male rats in terms of both the DAT trafficking and hyperactivity induced by cocaine. Particularly, intraperitoneal (i.p.) administration of 5 mg/kg cocaine induced significant hyperactivity and DAT trafficking in female rats but not in male rats. After repeated cocaine exposures (i.e., i.p. administration of 20 mg/kg cocaine every other day from Day 0 to Day 32), cocaine‐induced hyperactivity in female rats gradually became a clear pattern of two phases, with the first phase of the hyperactivity lasting for only a few minutes and the second phase lasting for over an hour beginning at ~30 min, which is clearly different from that of male rats. It has also been demonstrated that the striatal DAT distribution of female rats may recover faster than that of male rats after multiple cocaine exposures. Nevertheless, despite the remarkable gender differences, our recently developed long‐acting cocaine hydrolase, known as CocH5‐Fc(M6), can similarly and effectively block cocaine‐induced DAT trafficking and hyperactivity in both male and female rats.
Prevalence of oral HPV in the adult sample population in Sydney
Authors: Rumianek B , Hillman R , Jeoffreys N , Ghazanfar S , Schifter M , Ajwani S 
Published: October 2022

AbstractBackgroundOropharyngeal squamous cell carcinomas are increasing in incidence. Risk factors include sexual behaviour, high‐risk oral HPV infection and poor oral hygiene. We aimed to provide initial information on the prevalence and assess the feasibility of testing in dental settings.MethodsPatients ≥18 years old attending dental clinics in Sydney, Australia, were recruited, oral hygiene assessed, and 10 mL saline oral rinses obtained. Rinses were tested for HBG and HPV by PCR. Participants completed demographic and behavioural questionnaires.ResultsThe mean age was 48 years, of whom 131 (43.6%) were male. HPV genotypes, one each of 16, 66, 51, 35 and 58 in five participants, and 18 and 52 in one participant, were detected in six samples (2.0%), all men. Oral sex was reported by 89 (67.9%) male participants. One participant (4.3%) of the 23 with poor OH had at least one HPV genotype detected.DiscussionWith dental patients willing to provide rinse samples and disclose potentially sensitive information, we found the hrHPV prevalence of 2%. Given large proportions of the general population attending dental clinics regularly, dentists may be ideally placed to screen for oropharyngeal carcinoma and contribute to the currently limited knowledge of oral HPV prevalence in Australian adults. © 2022 Australian Dental Association.
Gross anatomy, computed tomography, magnetic resonance imaging and bone mineral densitometry of the ovine metacarpo/metatarsophalangeal joint
Authors: Ghaderi Saeed , Goodarzi Nader 
Published: October 2022

AbstractThis study was aimed to provide anatomical atlas of the ovine metacarpo/metatarsophalangeal joints using computed tomography (CT) scan and magnetic resonance imaging (MRI), as well as to investigate bone mineral density (BMD) and morphometric features of this joint. The limbs of twenty adult Sanjabi sheep were examined. Imaging was performed using a 16‐slice multi‐detector CT scanner and a 1.5 Tesla MRI scanner. The obtained images were correlated with corresponding anatomical sections. BMD was measured by Dual Energy X‐ray Absorptiometry (DEXA) method. Also morphometric features included distance between metacarpal and metatarsal heads, width of metacarpal and metatarsal head, length, width and the height of the proximal sesamoid bones were measured. In MRI images, compact bones, ligaments and tendons showed less signal intensity (hypointense). The fatty tissue and bone marrow had more signal intensity (hyperintense), but articular cartilage and synovial fluid showed moderate signal intensity. BMD in the left hind limb was significantly higher than other three limbs (p ≤ 0.05). The length of proximal sesamoid bones in left forelimb was higher than right forelimb (p ≤ 0.05). The thickness of proximal sesamoid bones in left limbs was higher than those in their counterparts (p ≤ 0.05). The width of the medial head in the forelimbs was significantly greater than the hind limbs (p ≤ 0.05). The present results might be useful in managing the clinical techniques on this joint. Larger volume of the proximal sesamoid bones and wider medial head in the forelimbs compared to the hindlimbs impel this speculation that the centre of gravity is closer to the forelimbs.
Prognostic value of human epidermal growth factor receptor 2 status and systemic therapy in breast cancer with brain metastases treated with radiotherapy
Authors: Tsuruoka Shintaro , Kataoka Masaaki , Uwatsu Kotaro , Makita Kenji , Tsuruoka Kota , Takata Noriko , Ishikawa Hirofumi , Hamamoto Yasushi , Mochizuki Teruhito , Kido Teruhito 
Published: October 2022

AbstractPurposeTo evaluate the prognostic value of human epidermal growth factor receptor 2 (HER2) status and how to use HER2‐targeted therapy in breast cancer (BC) with brain metastases (BM) treated with radiotherapy.MethodsWe retrospectively reviewed the data of 103 BC patients with parenchymal BM treated with radiotherapy. We collected data on the hormone receptor (HR), HER‐2 amplification status, and systemic therapy after treatment for BM. The primary outcome was overall survival (OS), which was calculated from the diagnosis of BM to death.ResultsThe median follow‐up time from the diagnosis of the first BM was 9.1 months (range, .7–88 months). The 2‐year OS of the HR‐positive and HER2‐positive (HR+HER2+) BC (31.3 mo) was significantly better than those of the HR‐HER2+ (9,5 mo, p=.002), HR+HER2‐ (9.9mo, p=.003), and triple‐negative BC (3.9 mo, p<.001) ( . Of the 36 HER2‐positive patients, 31 patients treated with HER2‐targeted therapy after radiotherapy for BM had a significantly better 2‐year OS than those who did not receive HER2‐targeted therapy (43% vs. 0%; p < .001). Among the 31 patients treated with HER2‐targeted therapy, the 2‐year OS for those treated with multiple anti‐HER2 agents during the entire course of treatment was significantly higher than that for patients treated with a single agent (60% vs. 24%; p = .006).ConclusionsHR+HER2+ BC patients with BM treated with radiotherapy show a better prognosis than other subtypes. For HER2‐positive patients with good prognosis, it may be important to continue HER2‐targeted therapy appropriately after radiotherapy for BM.
Falshfasad
Authors: MURAWSKI MICHAŁ 
Published: October 2022

ABSTRACTZaryadye Park is an extravagant landscaping project–cum–multimedia attraction that opened in 2017 adjacent to Moscow's Kremlin. This article opens with a short reflection on the portents of war legible, with the benefit of hindsight, in Zaryadye's design. It navigates the thicket of aesthetics, ideologies, ecologies, and economies blossoming in Zaryadye, interrogating propagandistic characterizations of it as an ethereal terrain where infrastructure is altogether displaced by emotion, leisure, spectacle, and nature. Zaryadye has its Muscovite specificities, but it is merely one incarnation of a globally emergent architectural ideology—pseudo‐ecological, infrastructure‐disavowing—which I call “wild capitalist.” Looking for the locus of Zaryadye's really existing infrastructure(s), this article peers behind itsfalshfasady(false facades)—oversized tarps camouflaging the unsightly “reality” of construction work in 21st‐century Moscow. Methodologically, the article makes the case for a Marxist ethnographic realism as a suitable lens for depicting reality‐in‐motion in the wild‐capitalist moment. [infrastructure, architecture, postsocialism, fakeness, Marxism, materialism, realism, Moscow, Russia]
Comparison of transplant outcomes between haploidentical transplantation and single cord blood transplantation in non‐remission acute myeloid leukaemia: A nationwide retrospective study
Authors: Matsuda Kensuke , Konuma Takaaki , Fuse Kyoko , Masuko Masayoshi , Kawamura Koji , Hirayama Masahiro , Uchida Naoyuki , Ikegame Kazuhiro , Wake Atsushi , Eto Tetsuya , Doki Noriko , Miyakoshi Shigesaburo , Tanaka Masatsugu , Takahashi Satoshi , Onizuka Makoto , Kato Koji , Kimura Takafumi , Ichinohe Tatsuo , Takayama Nobuyuki , Kobayashi Hikaru , Nakamae Hirohisa , Atsuta Yoshiko , Kanda Junya , Yanada Masamitsu 
Published: October 2022

SummaryAllogeneic haematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for some patients with acute myeloid leukaemia (AML) who are refractory to chemotherapy. Cord blood transplantation (CBT) is a reasonable option in such cases because of its rapid availability. Recently, a growing number of human leucocyte antigen (HLA)‐haploidentical related donor HSCTs (haplo‐HSCTs) have been performed, although its effectiveness remains undetermined. Using the Japanese nationwide transplantation registry data, we identified 2438 patients aged ≥16 years who received CBT or haplo‐HSCT as their first transplant for non‐remission AML between January 2008 and December 2018. After 2:1 propensity score matching, 918 patients in the CBT group and 459 patients in the haplo‐HSCT group were selected. In this matched cohort, no significant difference in overall survival (OS) was observed between the CBT and haplo‐HSCT groups (hazard ratio [HR] of haplo‐HSCT to CBT 1.02, 95% confidence interval [CI] 0.89–1.16). Similarly, no significant difference in the cumulative incidence of relapse (HR 1.09, 95% CI 0.93–1.28) or non‐relapse mortality (HR 0.94, 95% CI 0.76–1.18). Subgroup analysis showed that CBT was significantly associated with preferable OS in patients receiving myeloablative conditioning. Our data showed comparable outcomes between haplo‐HSCT and CBT recipients with non‐remission AML.
United we stand, divided we fall. Multicentre standardization of measurable residual disease assessment in acute leukaemia is the way forward
Authors: Chatterjee Gaurav , Patkar Nikhil 
Published: October 2022

Assessment of measurable residual disease (MRD) using multiparameter flow cytometry in precursor B‐cell acute lymphoblastic leukaemia (ALL) is routine. However, studies on the harmonization of laboratory techniques as well as on the interpretation of results are limited. Here, Ikoma‐Colturato and colleagues from Brazil demonstrate multicentric standardization of B‐ALL MRD using EuroFlow protocols.Commentary on: Ikoma‐Colturato et al., Multicentric standardization of minimal/measurable residual disease in B‐cell precursor acute lymphoblastic leukaemia using next‐generation flow cytometry in a low/middle‐level income country. Br J Haematol 2023;200:381‐384.
Intraoperative rapid immunohistochemistry with noncontact antibody mixing for undiagnosed pulmonary tumors
Authors: Imai Kazuhiro , Nanjo Hiroshi , Shigeeda Wataru , Sugai Tamotsu , Ito Tomoo , Maniwa Yoshimasa , Takashima Shinogu , Saito Hajime , Yanagawa Naoki , Tanaka Yugo , Doi Takefumi , Hiroshima Yuko , Nomura Kyoko , Tanino Mishie , Tanaka Shinya , Minamiya Yoshihiro ,   the R‐IHC Study Group
Published: October 2022

AbstractKnowledge of the histologic type and primary origin of pulmonary tumors is essential when preparing a surgical strategy. Intraoperative diagnosis of hematoxylin and eosin (H&E)‐stained frozen sections is the gold standard, but reliable pathology requires time‐consuming immunohistochemistry (IHC) to distinguish among histological types/organ origins and to analyze molecular status. The aim of this study was to evaluate the clinical reliability of a new rapid‐IHC technique for intraoperative diagnosis of pulmonary tumors. In total, 169 patients with undiagnosed pulmonary tumors were enrolled in a multicenter prospective observational study. At three institutes, pulmonary tumor samples were collected through core needle biopsy and/or surgery to determine surgical strategies. Using a new device for rapid IHC, we applied a high‐voltage, low‐frequency alternating current (AC) field, which mixes the available antibody as the voltage is switched on/off. Rapid IHC can provide tumor histologic type/origin diagnoses within 20 min, as opposed to the 3–6 h required for conventional IHC. No false diagnoses of malignancy were rendered in any of the cases when using simple H&E staining. With H&E staining alone, the overall definitive diagnosis rate, the rate of defined tumor origin, and the rate of determined histological type were 76.92%, 85.80%, and 90.53%, respectively. When rapid IHC was added, those rates were significantly improved to 88.76%, 94.67%, and 91.72%, respectively. By providing prompt and accurate intraoperative histological/molecular analysis, rapid IHC driven by AC mixing could serve as an effective clinical tool guiding the surgical strategy for undiagnosed pulmonary tumors.
Beyond survival: Strengthening community‐based support for parents receiving a family service intervention
Authors: Goff Rachel , Sadowski Christina , Bagley Kerryn 
Published: October 2022

AbstractThis paper presents parents' experiences of community support and their recommendations for how their communities, and the services within them, might support their families. Generated through a human‐centred design methodology and using a desire‐centred framework, the findings suggest that parents receiving a family service require support invoking feelings of intimacy, trust, reciprocity, inclusivity, connection and belonging. Parents' recommendations for community support include addressing material and attitudinal constraints impacting on engagement with services; creating non‐judgmental services tailored to their needs but accessed as a last resort; and creating peer‐based opportunities to support each other. Parents reflect that moving beyond basic survival of risk and vulnerability to a position where thriving is possible requires purposeful integration of parent's existing and desired community into service interventions. Facilitating deliberate change at the intersection of community and service support is pertinent to current and future social work policy and practice. Wider opportunities for understanding and enabling the needs and aspirations of parents, which are often overlooked because of a focus on addressing risk and vulnerability, are considered.
Natural and artificial inoculation of radiata pine boles and seedlings with Phytophthora ramorum, causal agent of sudden oak death, reveals low host potential
Authors: Daniels Hazel A. , Bulman Lindsay , LeBoldus Jared M. 
Published: October 2022

AbstractRadiata pine is an important plantation tree; more than 4 million ha are planted globally, and 90% of planted forests in Aotearoa New Zealand are radiata pine. It is susceptible to several root and foliar diseases caused by Phytophthora species, and is potentially susceptible to Phytophthora ramorum, the pathogen responsible for sudden oak death in the United States and Europe. A series of experiments were conducted to determine the potential risk of P. ramorum infection to radiata pine logs and seedlings in the context of forest harvest and replanting. In a natural inoculation experiment, bolts of radiata pine, Douglas‐fir and tanoak were exposed to P. ramorum inoculum produced from sporulating tanoak canopies infected with either the NA1 or EU1 lineage of P. ramorum. The experiment occurred at four sites, two NA1 and two EU1, across 2 years. Four per cent of radiata pine bolts, 8% of tanoak bolts and 0% Douglas‐fir bolts tested positive for P. ramorum. Artificial inoculations of bolts of the same species revealed a significant effect of lineage (p = .0024), species (p < .0001) and their interaction (p = .0027) on lesion length. Species was the only parameter that had a significant impact on average lesion length (p < .0001) and sporulation (p = .00144) from seedlings. No sporangia were observed on radiata pine seedlings (n = 60); few were observed on tanoak and Douglas‐fir. Although radiata pine can be colonized by P. ramorum, without a sporulating host in proximity it does not appear to be at high risk from this pathogen.
Reconstructive blepharoplasty following eyelid melanoma excision using a sliding skin flap in six horses
Authors: Rose Beth L. , Mair Tim S. 
Published: October 2022

SummaryMelanomas are common in grey horses, and the eyelid is one of the less common predilection sites. The eyelids play an important role in maintaining ocular health, and damage to the eyelid margin can lead to ocular complications, including ocular pain, conjunctivitis and ulcerative keratitis. Surgical procedures to remove eyelid tumours, therefore, often require reconstruction techniques to re‐establish the eyelid's appearance and function. The sliding skin flap is a simple surgical technique that can be applied to close the defect resulting from surgical excision of eyelid tumours such as melanomas, but there is little published data about the short‐ and long‐term outcomes of this procedure in the horse. This case report reviews six horses where a sliding skin flap was used to reconstruct the eyelid after excision of discrete eyelid melanomas, with short‐ and long‐term follow‐up of the cases. Short‐term complications (including corneal abrasion from a suture) were uncommon (two cases), and there were no reported long‐term complications (follow‐up period 6 months to 13 years), with no melanoma recurrence at the surgical site. However, new melanoma development at other sites of the body occurred in several cases.
The non‐reversal of delegation in international standard‐setting in finance: The Basel Committee and the European Union
Authors: Quaglia Lucia 
Published: October 2022

AbstractInternational non‐majoritarian institutions (NMIs) in finance have proliferated over the last decades. The Basel Committee on Banking Supervision (BCBS) is the main international NMI in finance and the European Union (EU) is one of its core jurisdictions. Despite the far‐reaching effects of international banking standards in the EU, especially the Basel accords, there has been limited politicization of delegation to the BCBS and no attempt to reverse it. Why? By taking a “soft” principal‐agent approach, this paper points out two explanatory factors: the composite nature of both the principal and the agent. It also identifies a pattern that can be generalized to other international NMIs in finance. Thus, following the initial delegation of international standard‐setting to the BCBS, this international NMI considerably increased its activities, going beyond what certain elected officials wanted; the response from elected officials was limited to the use of relatively weak ex‐ante and ex‐post controls, including delayed compliance.
Handheld ultrasound‐guided cannulation of difficult hemodialysis arteriovenous access: A randomized controlled trial
Authors: Chen Shune , Liu Justin Shuang , Chai Chung Cheen , Si Chanjuan , Tan Si Hui , Ravindran Hanita Rajah , Martinez Ma Teresa Pedrosa , Gao Yang , Yeap Ying Ru , Liu Allen Yan Lun 
Published: October 2022

AbstractIntroductionCannulation of complex arteriovenous fistula (AVF) or graft (AVG) frequently poses challenges to renal nursing practice. Ultrasound (US) guidance on visualizing central and peripheral venous access has been widely adopted in nephrology, reducing vascular intervention complications. Renal nurses could acquire this point‐of‐care technique to increase the successful cannulation rate while facilitating confidence build‐up during practice. We aim to evaluate the use of handheld US on difficult AVF/AVG cannulation in a hospital‐based dialysis unit.MethodsWe conducted a single‐center randomized controlled trial from January 2021 to January 2022. Ten renal nurses were trained by an interventional nephrologist before patient recruitment and had completed a pre‐ and posttraining questionnaire on their confidence level. Fifty hemodialysis patients with complex AVF were randomized to US‐guided or conventional cannulation. The total time spent on cannulation and patients' pain scores were also collected.FindingsRenal nurses increased their confidence level after training (pretraining score 26.6 ± 6.9 vs. posttraining score 36.4 ± 3.0; p = 0.014). There was a higher success rate (only one cannulation attempt required) for US‐guided (96%) versus conventional (72.0%) cannulation (p = 0.049). US‐guided cannulation had a lower pain score than the conventional method (1.48 ± 0.73 vs. 2.13 ± 0.95, p = 0.012). The pre‐cannulation assessment time and time spent on cannulation were comparable between the two groups.DiscussionOur study showed that US‐guided cannulation increased renal nurses' confidence level in difficult cannulation and improved success rate. Larger scale studies are required to further assess the applications of handheld US in AVF cannulation, particularly in different clinical settings (e.g., chronic dialysis centers).