bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological and prognostic significance of long non-coding RNA EWSAT1 in human cancers: A review and meta analysis
Authors: Wen Jian , Li Haima , Li Dongdong , Dong Xieping 
Published: March 2022

Background
Ewing sarcoma-associated transcript 1 (lncRNA EWSAT1) is reported to have a close relationship with the overall survival in many cancers. However, the role of its prognosis and correlations with the clinicopathological features in different cancers haven’t been explored yet. Herein, we intend to assess the prognostic value and correlations with the clinicopathological features in several cancers.

Methods
PubMed, Embase, Web of Science, and The Cochrane Library were searched for literature review from inception to October 25, 2021. Valid data was extracted to make forest and sensitivity analysis plots using Review Manager 5.4 and Stata software. Hazard ratio (HR) or odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the relationship between different expression of EWSAT1 and patients’ prognosis and clinicopathological features.

Results
7 studies were screened for this review, including 550 samples. Meta-analysis showed that high expression of lncRNA EWSAT1 was associated with poor overall survival (OS) (HR = 2.10, 95% CI, 1.60–2.75, p < 0.0001) in cancers reported. In addition, patients in high expression group of EWAST1 tended to have more metastasis (OR = 2.20, 95% CI 1.47–3.31, p = 0.0001), and higher TNM stage (I+II vs. III: OR = 0.34, 95% CI 0.21–0.56, p < 0.0001), but in the same time with higher differentiation (well + moderate vs. Poor: OR = 2.21, 95% CI 1.02–4.76, p = 0.04). Age (OR = 1.47, 95% CI 0.94–2.30, p = 0.09) was not significantly different in patients with aberrant expression of EWSAT1.

Conclusions
Our study shows that high expression of EWSAT1 may indicate poor overall survival and associated with several clinicopathological features, which can be used as a potential prognosis biomarker for multiple cancers.
Feasibility of wireless continuous monitoring of vital signs without using alarms on a general surgical ward: A mixed methods study
Authors: Leenen Jobbe P. L. , Rasing Henriëtte J. M. , van Dijk Joris D. , Kalkman Cor J. , Schoonhoven Lisette , Patijn Gijs A. 
Published: March 2022

Background
Wireless continuous vital sign monitoring by wearable devices have recently become available for patients on general wards to promote timely detection of clinical deterioration. Many continuous monitoring systems use conventional threshold alarm settings to alert nurses in case of deviating vital signs. However, frequent false alarms often lead to alarm fatigue and inefficiencies in the workplace. The aim of this study was to determine the feasibility of continuous vital sign monitoring without the use of alarms, thereby exclusively relying on interval trend monitoring.

Methods
This explanatory sequential mixed methods study was conducted at an abdominal surgical ward of a tertiary teaching hospital. Heart rate and respiratory rate of patients were measured every minute by a wearable sensor. Trends were visualized and assessed six times per day by nurses and once a day by doctors during morning rounds. Instead of using alarms we focused exclusively on regular vital sign trend analysis by nurses and doctors. Primary outcome was feasibility in terms of acceptability by professionals, assessed by the Usefulness, Satisfaction and Ease of Use questionnaire and further explored in two focus groups, as well as fidelity.

Results
A total of 56 patients were monitored and in 80.5% (n = 536) of nurses’ work shifts the trends assessments were documented. All deviating trends (n = 17) were recognized in time. Professionals (N = 46) considered continuous monitoring satisfying (4.8±1.0 on a 1–7 Likert-scale) and were willing to use the technology. Although insight into vital sign trends allowed faster anticipation and action upon changed patient status, professionals were neutral about usefulness (4.4±1.0). They found continuous monitoring easy to use (4.7±0.8) and easy to learn (5.3±1.0) but indicated the need for gaining practical experience. Nurses considered the use of alarms for deviating vital signs unnecessary, when trends were regularly assessed and reported.

Conclusion
We demonstrated that continuous vital signs trend monitoring without using alarms was feasible in the general ward setting, thereby avoiding unnecessary alarms and preventing alarm fatigue. When monitoring in a general ward setting, the standard use of alarms may therefore be reconsidered.
Family Ties and Corruption
Authors: Litina Anastasia , Varvarigos Dimitrios 
Published: March 2022

Abstract
We study the relation between nuclear family ties and corruption. Our theoretical model shows that the population share of people who desire close ties with their families (i.e. the extensive margin) has an ambiguous effect on the level of corruption, due to the presence of conflicting mechanisms. However, the strength of this desire among people who want close family ties (i.e. the intensive margin) has an unambiguously negative effect on corruption. The latter outcome finds support from our empirical analysis: Using micro-level data, we show that, in contrast to conventional wisdom and cross-country reflections, stronger family ties are negatively correlated with a broad set of activities that measure corruption.
Evaluation of a faecal calprotectin method using the OC-SENSOR PLEDIA
Authors: O’Driscoll Shane , Piggott Carolyn , Benton Sally C. 
Published: March 2022

Abstract

Objectives
The National Institute for Health and Care Excellence recommends faecal calprotectin (f-cal) to help differentiate inflammatory bowel diseases from irritable bowel syndrome. Faecal samples for calprotectin have historically been collected at home by patients into screw-top pots and sent to laboratories where calprotectin is extracted and analysed. Faecal haemoglobin (f-Hb) samples are collected at home into specific collection devices containing stabilising buffer. We evaluated the OC-FCa method for f-cal, developed by Eiken Chemical Co., Ltd. (Japan) that uses the same collection device and analyser as f-Hb.

Methods
OC-FCa was assessed for limit of blank (LOB), limit of detection (LOD), limit of quantification (LOQ), within and between-run imprecision, linearity, prozone, recovery and carryover. A method comparison against the BÜHLMANN fCAL® turbo (BÜHLMANN Laboratories AG, Switzerland) was performed using patient samples and EQA.

Results
The LOB was 3 µg calprotectin/g faeces (µg/g), LOD 8 μg/g and LOQ 20 μg/g. Within and between-run imprecision was <5%; linearity was good (R2 > 0.99); prozone was appropriately detected; recovery was 99.6%; no observed carryover. OC-FCa showed a strong positive bias compared with BÜHLMANN fCAL® turbo (Z=−5.3587, p < 0.001). When categorised using our local pathway, which interprets calprotectin concentrations and need for further investigation, Cohen’s Kappa demonstrates substantial agreement at <50 μg/g (κ=0.80) and >150 μg/g (κ=0.63) and fair agreement (κ=0.22) in the borderline category 50–150 μg/g.

Conclusions
The OC-FCa method performed well in the evaluation. With the lack of standardisation for f-cal a clinical study is required to evaluate the positive bias and establish suitable cut-off levels.
Polystable bundles and representations of their automorphisms
Authors: Buchdahl Nicholas , Schumacher Georg 
Published: March 2022

AbstractUsing a quasi-linear version of Hodge theory, holomorphic vector bundles in a neighbourhood of a given polystable bundle on a compact Kähler manifold are shown to be (poly)stable if and only if their corresponding classes are (poly)stable in the sense of geometric invariant theory with respect to the linear action of the automorphism group of the bundle on its space of in˝nitesimal deformations.
Tone and the prosodic stem in Malawian CiTonga
Authors: Mkochi Winfred , Bickmore Lee 
Published: March 2022

AbstractIn CiTonga, a Bantu language spoken in northern Malawi, a number of different morphemes within the verbal complex can sponsor a High tone. While the High tone of a morpheme which precedes the stem is shown to be underlyingly pre-linked, those found after the beginning of the stem are argued to be underlyingly floating. This latter group of High tone autosegments can be shown to exclusively dock onto the first and last tone bearing units (TBUs) of the prosodic stem. This domain is not isomorphic with the morphological stem in that it must include the entire morphological stem as well as any of 3 different categories of enclitics which follow. The docking of the underlyingly floating Hs is shown to follow an edge-in process whereby a single H docks onto the initial TBU of the prosodic stem, a second H docks onto the final TBU of the prosodic stem, and any additional High tones remain floating, being phonologically inert. The paper provides an extensive range of newly presented data on this understudied Bantu language and constitutes a rare case of the prosodic stem being motivated by tonological factors.
Moderate-intensity exercise decreases the circulating level of betatrophin and its correlation among markers of obesity in women
Authors: Rejeki Purwo Sri , Baskara Pradika Gita , Herawati Lilik , Pranoto Adi , Setiawan Hayuris Kinandita , Lesmana Ronny , Halim Shariff 
Published: March 2022

Abstract

Objectives
Positive energy homeostasis due to overnutrition and a sedentary lifestyle triggers obesity. Obesity has a close relationship with elevated levels of betatrophin and may increase the risk of developing metabolic syndrome. Therefore, lifestyle modification through a nonpharmacological approach based on physical exercise is the right strategy in lowering betatrophin levels. This study aimed to analyze the effect of moderate-intensity interval and continuous exercises on decreased betatrophin levels and the association between betatrophin levels and obesity markers in women.

Methods
A total of 30 women aged 20–24 years old were randomly divided into three groups. Measurement of betatrophin levels using Enzyme-Linked Immunosorbent Assay (ELISA). Data analysis techniques used were one-way ANOVA and parametric linear correlation.

Results
The results showed that the average levels of betatrophin pre-exercise were 200.40 ± 11.03 pg/mL at CON, 203.07 ± 42.48 pg/mL at MIE, 196.62 ± 21.29 pg/mL at MCE, and p=0.978. Average levels of betatrophin post-exercise were 226.65 ± 18.96 pg/mL at CON, 109.31 ± 11.23 pg/mL at MIE, 52.38 ± 8.18 pg/mL at MCE, and p=0.000. Pre-exercise betatrophin levels were positively correlated with age, BMI, FM, WHR, FBG, and PBF (p≤0.001).

Conclusions
Our study showed that betatrophin levels are decreased by 10 min post-MIE and post-MCE. However, moderate-intensity continuous exercise is more effective in lowering betatrophin levels than moderate-intensity interval exercise. In addition, pre-exercise betatrophin levels also have a positive correlation with obesity markers.
Simple yet sharp sensitivity analysis for unmeasured confounding
Authors: Peña Jose M. 
Published: March 2022

Abstract
We present a method for assessing the sensitivity of the true causal effect to unmeasured confounding. The method requires the analyst to set two intuitive parameters. Otherwise, the method is assumption free. The method returns an interval that contains the true causal effect and whose bounds are arbitrarily sharp, i.e., practically attainable. We show experimentally that our bounds can be tighter than those obtained by the method of Ding and VanderWeele, which, moreover, requires to set one more parameter than our method. Finally, we extend our method to bound the natural direct and indirect effects when there are measured mediators and unmeasured exposure–outcome confounding.
Improvement of forging die life by failure mechanism analysis**
Authors: Abd AL-Kareem Ahmed Ibrahim , Mohammed Adnan Ibrahim , Allow Munir Ahmed 
Published: March 2022

Abstract
This study analyses the causes of rapid failure at the early stages of hot forging tools. Tool life generally refers to the number of forgings that meet the required geometry, properties and quality produced by a tool. Die failure in hot forging processes are caused by failure modes such as plastic deformation, wear and thermomechanical fatigue. This study focuses on plastic deformation failure. The practical experience was carried out in the upset forge fastener head, having a workpiece material of Ck45 alloy steel and tool made of 56 NiCrMoV7 tool material, which was forged at 950–1150°C, under an 800-ton, horizontal mechanical press. The finite element (FE) software MSC Simufact Forming 16.0 was used to simulate the process. The results showed plastic deformation occurring in the upper and lower dies because the temperature increase progressively reduced the hardness, creating softening effects during the forging process. The optimal forging temperature to form the fastener head was determined to be lower at 1000°C, saving time and cost. The FE method can be efficiently used to enhance the formation and to predict diet life.
Review of medication-assisted treatment for opioid use disorder
Authors: Ghanem Nessreen , Dromgoole Devin , Hussein Ahmad , Jermyn Richard T. 
Published: March 2022

Abstract

Context
The American opioid epidemic has necessitated the search for safe and effective means of treatment for opioid use disorder (OUD). Medication-assisted treatment (MAT) encompasses select medications that are proven effective treatments for OUD. Understanding the mechanisms of action, indications, and implementation of MAT is paramount to increasing its availability to all individuals struggling with opioid addiction.

Objectives
This review is based on an educational series that aims to educate healthcare providers and ancillary healthcare members on the use of MAT for the treatment of OUD.

Methods
The database PubMed was utilized to retrieve articles discussing the implementation of MAT. Boolean operators and Medical Subject Headings (MeSHs) were applied including: MAT and primary care, MAT and telehealth, methadone, buprenorphine, naltrexone, MAT and osteopathic, MAT and group therapy, and MAT and COVID-19.

Results
Three medications have been approved for the treatment of OUD: methadone, naltrexone, and buprenorphine. Identifying ways to better treat and manage OUD and to combat stigmatization are paramount to dismantling barriers that have made treatment less accessible. Studies suggest that primary care providers are well positioned to provide MAT to their patients, particularly in rural settings. However, no study has compared outcomes of different MAT models of care, and more research is required to guide future efforts in expanding the role of MAT in primary care settings.

Conclusions
The coronavirus disease 2019 (COVID-19) pandemic has led to changes in the way MAT care is managed. Patients require a novel point-of-care approach to obtain care. This review will define the components of MAT, consider the impact of MAT in the primary care setting, and identify barriers to effective MAT. Increasing the availability of MAT treatment will allow for greater access to comprehensive treatment and will set the standard for accessibility of novel OUD treatment in the future.
The use of antenatal corticosteroids for fetal maturation: clinical practice guideline by the WAPM-World Association of Perinatal Medicine and the PMF-Perinatal Medicine foundation
Authors: Dagklis Themistoklis , Sen Cihat , Tsakiridis Ioannis , Villalaín Cecilia , Karel Allegaert  , Wellmann Sven , Kusuda Satoshi , Serra Bernat , Sanchez Luna Manuel , Huertas Erasmo , Volpe Nicola , Ayala Rodrigo , Jekova Nelly , Grunebaum Amos , Stanojevic Milan 
Published: March 2022

Abstract
This practice guideline follows the mission of the World Association of Perinatal Medicine in collaboration with the Perinatal Medicine Foundation, bringing together groups and individuals throughout the world, with the goal of improving the use of antenatal corticosteroids (ACS) for fetal maturation. In fact, this document provides further guidance for healthcare practitioners on the appropriate use of ACS with the aim to increase the timely administration and avoid unnecessary or excessive use. Therefore, it is not intended to establish a legal standard of care. This document is based on consensus among perinatal experts throughout the world and serves as a guideline for use in clinical practice.
Gegenständliche Erkenntnis und transzendentale Einsicht. Zum Kantverständnis Joachim Koppers
Authors: Kopper Margit 
Published: March 2022

Abstract
This article provides a short survey of Joachim Kopper’s understanding of Kant’s theory of cognition in CPR. Kant’s critical thought is developed via a dogmatic method but marks a transition to transcendental thought delivered from dogmatic assertions. The assertion that cognition emerges from the relation between mind and objects is made at the beginning of CPR. Kopper holds that transcendental reflection starts not on the basis of this distinction but on the impossibility of logical assertion about existence as it is reached in antinomic. The fact of experience must thus be explained otherwise than by dogmatic assertions of relations between objects or between objects and thought. Reflection on necessity, affirmed by the law of causality, enables transcendental inspection to understand experience and human life in one unrelational meaning.
Ultra-fast x-ray tomography for multi-phase flow interface dynamic studies
Authors: Misawa M. , Tiseanu I. , Prasser H.-M. , Ichikawa N. , Akai M. 
Published: March 2022

Abstract

The present paper describes the concept of a fast scanning Xray tomograph, the hardware development, and measurement results of gas-liquid two-phase flow in a vertical pipe. The device uses 18 pulsed X-ray sources activated in a successive order. In this way, a complete set of 18 independent projections of the object is obtained within 38 ms, i. e. the measuring rate is about 250 frames per second. Finally, to evaluate the measurement capability of the fast X-ray CT, a wire-mesh sensor was installed in the flow loop and both systems were operated for the same two-phase flow simultaneously. Comparison of the time series of the cross section averaged void fraction from both systems showed sufficient agreement for slug flow at large void fractions, while the fast CT underestimated the void fraction of bubbly flow especially in low void fraction range. For the wire-mesh sensor, coerced deformation of slug bubble interface was found. Further hardware improvement is in progress to achieve better resolution with the fast X-ray CT scanner.
Status and prospects of electronic personal dosemeters for neutron/photon radiation fields
Authors: Luszik-Bhadra M. , Rimpler A. , Wahl W. 
Published: March 2022

Abstract
For neutron radiation and mixed neutron/photon radiation fields, only a few types of direct reading dosemeters are commercially available or under development. Some important features of these dosemeters are briefly outlined and their energy dependent dose equivalent response and suitability for operational monitoring tasks in nuclear facilities, in particular, are discussed.
High-efficiency generation of far-field spin-polarized wavefronts via designer surface wave metasurfaces
Authors: Pan Weikang , Wang Zhuo , Chen Yizhen , Li Shiqing , Zheng Xiaoying , Tian Xinzhang , Chen Cong , Xu Nianxi , He Qiong , Zhou Lei , Sun Shulin 
Published: March 2022

Abstract
Achieving a pre-designed scattering pattern from an ultra-compact platform is highly desired for on-chip integration optics, but conventional techniques suffer from the limitations of bulky size, wavelength-scale modulation and low efficiency. Here, we propose a new strategy to efficiently generate arbitrary spin-polarized scattering far-field patterns from surface-wave (SW) excitations on a designer Pancharatnam–Berry (PB) metasurface. We find that a PB meta-atom serves as a subwavelength scatter to decouple impinging SW to a spin-polarized propagating wave (PW) with tailored amplitude and phase, and thus interference among PWs generated by scatterings at different PB meta-atoms can generate a tailored far-field pattern. As a proof of concept, we design and fabricate a series of PB metasurfaces in the microwave regime and experimentally demonstrate that they can generate desired radiation patterns within a broad frequency band, including unidirectional radiation, line/point focusing, vortex beam and hologram. These findings may stimulate important applications in on-chip integrated photonics.
Multiple velocity composition in the standard synchronization
Authors: Choi Yang-Ho 
Published: March 2022

Abstract
Mansouri and Sexl (MS) presented a general framework for coordinate transformations between inertial frames, presupposing a preferred reference frame the space-time of which is isotropic. The relative velocity between inertial frames in the standard synchronization is shown to be determined by the first row of the transformation matrix based on the MS framework. Utilizing this fact, we investigate the relativistic velocity addition. To effectively deal with it, we employ a diagram of velocity that consists of nodes and arrows. Nodes, which are connected to each other by arrows with relative velocities, represent inertial frames. The velocity composition law of special relativity has been known to be inconsistent with the reciprocity principle of velocity, through the investigation of a simple case where the inertial frames of interest are connected via a single node. When they are connected through more than one node, many inconsistencies including the violation of the reciprocity principle are found, as the successive coordinate transformation is not reduced to a Lorentz transformation. These inconsistencies can be cured by introducing a reference node such that the velocity composition is made in conjunction with it. The reference node corresponds to the preferred frame. The relativistic velocity composition law has no inconsistencies under the uniqueness of the isotropic frame.
Sodium dodecyl benzene sulfonate (SDBS) and N,N-dimethyldodecan-1-amine oxide (DDAO) in single and mixed systems as corrosion inhibitors of zinc in hydrochloric acid
Authors: Abdel-Rahem Rami A. , Niaz Sana , Altwaiq Abdelmnim M. , Esaifan Muayad , AlShamaileh Ehab , Al Bawab Abeer 
Published: March 2022

Abstract
The influence of surfactant synergism between sodium dodecyl benzene sulfonate (SDBS) and N,N-dimethyldodecan-1-amine Oxide (DDAO) on zinc corrosion in 0.05 M hydrochloric acid (HCl) solutions at 25 °C was investigated. Firstly, solutions of SDBS and DDAO with mole fractions of 0.00, 0.25, 0.50, 0.75 and 1.00 were prepared and their surface tension and critical micelle concentration (CMC) values in water and in 0.05 M HCl were measured as a function of total surfactant concentration. The SDBS/DDAO mixed system exhibited a strong synergism in 0.05 M HCl with a highly negative interaction parameter β (average β = −23.46), according to regular solution theory. Secondly, the adsorption of single surfactants SDBS and DDAO and SDBS/DDAO surfactant mixture on 2.0% zinc powder was investigated by the depletion method to find out the role of synergism in the adsorption tendency of these surfactants on the zinc surface and thus their corrosion inhibiting effect. The adsorption tendency of single surfactant and the mixed surfactant systems onto 2.0% zinc powder followed the order: SDBS > 0.75 SDBS/0.25 DDAO ≈ 0.25 SDBS/0.75 DDAO > DDAO > 0.50 SDBS/0.50 DDAO. Finally, the corrosion of zinc was investigated using the potentiodynamic polarization technique. It was found that SDBS and DDAO act as efficient corrosion inhibitors for zinc in 0.05 M HCl solution with increasing corrosion inhibition efficiency when they are mixed. Additionally, images of scanning electron microscopy were obtained for zinc sheets in solutions containing single and mixed SDBS/DDAO surfactants in the presence and absence of 0.05 M HCl. The microscopic images show an improvement in the protection of the zinc surface against acid attack in the presence of single and mixed SDBS/DDAO surfactants.