bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comprehensive Overview of the Complex Role of Oxidative Stress in Aging, The Contributing Environmental Stressors and Emerging Antioxidant Therapeutic Interventions
Authors: Iakovou Evripides , Kourti Malamati 
Published: June 2022

IntroductionAging is a normal, inevitable, irreversible, and progressive process which is driven by internal and external factors. Oxidative stress, that is the imbalance between prooxidant and antioxidant molecules favoring the first, plays a key role in the pathophysiology of aging and comprises one of the molecular mechanisms underlying age-related diseases. However, the oxidative stress theory of aging has not been successfully proven in all animal models studying lifespan, meaning that altering oxidative stress/antioxidant defense systems did not always lead to a prolonged lifespan, as expected. On the other hand, animal models of age-related pathological phenotypes showed a well-correlated relationship with the levels of prooxidant molecules. Therefore, it seems that oxidative stress plays a more complicated role than the one once believed and this role might be affected by the environment of each organism. Environmental factors such as UV radiation, air pollution, and an unbalanced diet, have also been implicated in the pathophysiology of aging and seem to initiate this process more rapidly and even at younger ages.AimThe purpose of this review is to elucidate the role of oxidative stress in the physiology of aging and the effect of certain environmental factors in initiating and sustaining this process. Understanding the pathophysiology of aging will contribute to the development of strategies to postpone this phenomenon. In addition, recent studies investigating ways to alter the antioxidant defense mechanisms in order to prevent aging will be presented.ConclusionsCareful exposure to harmful environmental factors and the use of antioxidant supplements could potentially affect the biological processes driving aging and slow down the development of age-related diseases. Maybe a prolonged lifespan could not be achieved by this strategy alone, but a longer healthspan could also be a favorable target.
The Relationship Between Suboptimal Social Networks and Postoperative Delirium: The PNDABLE Study
Authors: Tang Xinhui , Yv Hui , Wang Fei , Wang Jiahan , Liu Siyv , Wu Xiaoyue , Dong Rui , Lin Xu , Wang Bin , Bi Yanlin 
Published: June 2022

BackgroundAlthough it has been proven that social networks are related to cognition, studies are conducted to characterize the correlation between social networks and postoperative delirium (POD).ObjectiveWe investigated whether suboptimal social networks are a risk factor for POD, and to verify whether different levels of intimacy in the same social relationship can affect the concentration of cerebrospinal fluid (CSF) biomarkers, such as amyloid-β (Aβ42), total tau (T-tau), and phosphorylated tau (P-tau), and the mediating role of CSF biomarkers between social network and POD in middle-aged and elderly Han people.MethodsOur study recruited 743 participants from The Perioperative Neurocognitive Disorder and Biomarker Lifestyle (PNDABLE) study. Confusion Assessment Method (CAM) was used to evaluate the incidence of POD and its severity was measured using the Memorial Delirium Assessment Scale (MDAS). The social networks were measured using self-reported questionnaires about social ties. Mann–Whitney U test, Logistic Regression and Independent-samples test were used for Statistical Analysis.ResultsThe incidence of POD was 20.7%. Mann–Whitney U test showed that the total score of the social network was associated with POD (P &lt; 0.001). Independent-samples test showed that different levels of intimacy in the same social relationship were significantly associated with CSF POD biomarkers, and mediation analyses revealed that the association between suboptimal social networks and POD was partially mediated by T-tau (proportion: 20%), P-tau (proportion: 33%), Aβ42/T-tau (proportion: 14%), and Aβ42/P-tau (proportion: 15%).ConclusionHaving suboptimal social networks is a risk factor for POD in middle-aged and elderly Han people. CSF POD biomarkers can mediate the correlation between suboptimal social networks and POD, which is mainly mediated by tau protein.Clinical Trial Registrationwww.chictr.org.cn, identifier ChiCTR2000033439.
Long-Term Antipsychotic Effectiveness and Comparison of the Efficacy of Monotherapy and Polypharmacy in Schizophrenia: A 3-Years Follow-Up “Real World” Study in China
Authors: Zhang Lei , He Sidi , He Luyao , Yu Wenjuan , He Shen , Li Yange , Yu Yimin , Zheng Qingshan , Huang Jingjing , Shen Yifeng , Li Huafang 
Published: June 2022

Background: Discontinuation of antipsychotic treatment is a common problem in patients with schizophrenia and could reduce the effectiveness of treatment. Time to discontinuation (TTD) is one of the indicators of compliance and may also be an effective indicator of medication efficacy. The aim of the study was to compare the clinical effectiveness of quetiapine, olanzapine, risperidone, and aripiprazole in the real-world treatment of schizophrenia with 3-years follow-up.Method: A multi-center, open, cohort, prospective, real-world study was conducted. 706 patients were analyzed without intervention in medication selection and use, followed up for 3 years. Kaplan-Meier survival curves were used to draw the treatment discontinuation rates (TDR) curves at each time point. Cox proportional hazard regression model was used to assess the relative risk of TTD of antipsychotics.Results: There was a significant difference among monotherapy groups in all-cause antipsychotic treatment discontinuation (p = 0.0057). Among the four medications, the TDR of risperidone was the highest. Compared with polypharmacy, except for aripiprazole, the TDR of other three monotherapy medications were lower than that of polypharmacy, and olanzapine was statistically different (p = 0.0325). The cox regression analysis showed that after correction of Hochberg with multiple tests, only olanzapine had a relative risk lower than risperidone (p &lt; 0.0083).Conclusions: The findings indicated that risperidone monotherapy and polypharmacy had the highest TDR and the shortest TTD. Olanzapine monotherapy had a relative risk lower than risperidone and was superior to polypharmacy.
Proteomic Analysis of Potential Targets for Non-Response to Infliximab in Patients With Ulcerative Colitis
Authors: Liu Lu , Pu Dan , Wang Dandan , Zhang Muhan , Zhou Chuan , Zhang Zhe , Feng Baisui 
Published: June 2022

Background: Infliximab (IFX) is a potent therapeutic agent used for the treatment of conventional refractory ulcerative colitis (UC). However, the high non-response rate of IFX brings difficulties to clinical applications. In the context of proteomics research, our study of differentially expressed proteins (DEPs) is essential for non-response to IFX in UC patients and provides powerful insights into underlying drug resistance mechanisms.Methods: A total of 12 UC patients were divided into responders to IFX (UCinfG), non-responders to IFX (UCinfL), severe UC (UCsevere) without an IFX treatment history, and mild UC (UCmild) without an IFX treatment history. Subsequently, DEPs were identified from intestinal biopsy tissue between responders and non-responders to IFX by a label-free proteomic quantitative approach, and the general principle of functional protein screening was followed to deduce the potential drug targets and predictors for non-response to IFX in UC patients. Meanwhile, these targets excluded DEPs caused by the severity of inflammation for the first time. The differential expressions of candidate protein targets were validated at the gene sequence level using GEO2R analysis of the GEO database and qRT-PCR in some independent cohorts.Results: A total of 257 DEPs were screened out by mass spectrometry between UCinfG and UCinfL groups, excluding 22 DEPs caused by the severity of inflammation, and compared and verified at the gene sequence level in the Gene Expression Omnibus (GEO) database. Finally, five DEPs, including ACTBL2 (Q562R1), MBL2 (P11226), BPI (P17213), EIF3D (O15371), and CR1 (P17927), were identified as novel drug targets and predictive biomarkers for non-response to IFX. The drug targets were confirmed in the GEO database of the microarray results from three independent cohorts of 70 human intestinal biopsies and validated in qPCR data from 17 colonic mucosal biopsies. Among them, CR1 might affect the activation of the lectin pathway via complement-coated bacteria to play an opsonizing role in inflammation-related pathways closely associated with non-responders to IFX.Conclusion: This is the first report of proteomics analysis for the identification of novel drug targets based on intestinal biopsy tissue, which is significant for hypotheses for mechanistic investigation that are responsible for non-response to IFX and the development of clinical new pharmaceutical drugs.
Self-Perceived Employability of Workers With Disability: A Case Study in an Educational Farm
Authors: Fantinelli Stefania , Di Fiore Teresa , Marzuoli Alessia , Galanti Teresa 
Published: June 2022

BackgroundThe job placement of persons with disability is often threatened by prejudices and stereotypes; even when they are employed, they have less qualified and less paid jobs. The aim of this study was to investigate the self-perceived employability in a sample of workers with disability, hypothesizing to find a good level of self-determination and positive meaning of work.Materials and MethodsTen semi-structured interviews have been conducted, applying a mix-method to the data analysis through qualitative interpretation and quantitative content analysis. Results confirmed what recent literature shows about the need for job inclusiveness for persons with disability and also underlined a profound sense of satisfaction related to the job, strong identity, and empowerment derived from the job involvement.ConclusionPractical implications are related to the job design procedure inspired by diversity management, in order to pay attention to every single diversity and ensure equity and inclusion.
Mental Health Literacy and Mental Health Information-Seeking Behavior in Iranian University Students
Authors: Mahmoodi Seyed Mohammad Hossein , Ahmadzad-Asl Masoud , Eslami Mohammad , Abdi Mohadeseh , Hosseini Kahnamoui Yasamin , Rasoulian Maryam 
Published: June 2022

Background:Inadequate Mental health literacy (MHL) is a problem worldwide. Research is limited in developing countries and about positive MHL. This study measured the disease-oriented MHL and positive MHL and investigated their association. In addition, this study explored the mental health information-seeking behavior among undergraduate students in Iran.MethodsThis study recruited undergraduate students of Tehran public universities through multistage stratified random sampling to undertake an analytical cross-sectional study. MHL was measured using Mental Health Literacy Scale (MHLS) and Mental Health Positive Knowledge (MHPK). Participants' most used mental health information sources and their trust in them were also inspected.ResultsA total of 543 students participated in this study. On average, the participants achieved about 65% of the total possible MHLS score, and 71% of participants showed sufficient MHPK score. The “internet” was the most used source for receiving and searching for mental health information. The most trusted source was “health care staff”. This study detected no correlation between disease-oriented MHL and positive MHL.ConclusionsMental health literacy of Iranian students still seems to be insufficient. As disease-oriented MHL and positive MHL were not correlated, specific educational interventions for each domain are needed. Although the internet is the main source of mental health knowledge, the trust of student in it is low. This issue should be taken into consideration in designing online educational interventions.
The Need for Strengthening Health Information Dissemination Toward Indoor Residual Spraying for Malaria Prevention in Malarious Area of Ethiopia
Authors: Mekasha Wubayehu , Daba Chala , Malede Asmamaw , Debela Sisay Abebe , Gebrehiwot Mesfin 
Published: June 2022

IntroductionMalaria remains prevalent in developing countries. This is particularly true among the community who are prone but do not apply malaria prevention and controlling strategies. In one of the malarious areas of Ethiopia (Shewa Robit), the acceptance level of indoor residual spraying (IRS) is indicated to be low as per guidelines. However, factors determining communities' acceptance of IRS are not well-investigated. Hence, this study was designed to identify the determinants for the acceptance of IRS in order to indicate priorities for malaria prevention and control.MethodsA community-based cross-sectional study design was used among 649 households in Shewa Robit town, from February to March 2021. Households were selected from five IRS-targeted kebeles. Data were collected using structured questionnaire. A multivariable logistic regression model was used to identify the independent factors associated with the acceptance of IRS.ResultsThe response rate in this study was 98%. The proportion of community who accepted the IRS for malaria prevention was 56.5% [95% confidence interval (CI): 52.7–60.2%]. Being male [adjusted odds ratio (AOR) = 2.21, 95% CI: 1.32–3.72], having good knowledge (AOR = 2.25, 95% CI: 1.33–3.84), did not paint/re-plaster the wall after spraying (AOR = 3.99, 95% CI: 2.36–6.76), did not perceive any side effects after spraying (AOR = 1.82, 95% CI: 1.11–2.99), effectiveness of previous IRS (AOR = 2.99, 95% CI: 1.85–4.84), non-utilization of long-lasting insecticide-treated net (LLIN) (AOR = 0.52, 95% CI: 0.33–0.84), and spraying the house at the right season (AOR: 2.14, 95% CI: 1.11–4.13) were determinant factors for the acceptance of IRS.ConclusionsTo increase the acceptance level of IRS among the communities, health interventions and services should focus on the awareness creation toward the effectiveness of IRS, proper spraying time/season, and side effects of IRS. Therefore, strengthening health information dissemination could help promote the acceptance of IRS.
Effects of COVID-19 Lockdown on Physical Performance, Sleep Quality, and Health-Related Quality of Life in Professional Youth Soccer Players
Authors: Keemss Jil , Sieland Johanna , Pfab Florian , Banzer Winfried 
Published: June 2022

BackgroundIn March 2020, the COVID-19 outbreak led to the declaration of a pandemic. The accompanying restrictions on public life caused a change in the training routines of athletes worldwide. The present study aimed to investigate the effects of a 13-week supervised home training program on physical performance, sleep quality, and health-related quality of life in professional youth soccer players during the first COVID-19 lockdown in Germany.MethodsEight professional soccer players (age range 16–19; height: 1.81 ± 0.07 m; body weight: 72.05 ± 6.96 kg) from a Bundesliga team in Germany participated in this study. During the lockdown, they trained 5–6 days per week with home-based training plans and were monitored via tracking apps and video training. To determine the effects of home training, measurements were taken before (March 2020) and after (June 2020) the home training period. Bioelectrical impedance analysis was used to determine body composition, and an isokinetic strength test and a treadmill step test, including lactate measurements, were used to measure physical performance. Two questionnaires were responded to in order to assess health-related quality of life [Short-Form 36 Health Survey (SF-36)] and sleep quality (Pittsburgh Sleep Quality Index).ResultsWhen comparing measurements before and after the home training period, we observed significant increases in the following variables: body weight (72.05 ± 6.96 kg vs. 73.50 ± 6.68 kg, p = 0.034), fat mass (11.99 ± 3.13 % vs. 13.98 ± 3.92 %, p = 0.030), body mass index (22.04 ± 0.85 kg/m2 vs. 22.49 ± 0.92 kg/m2, p = 0.049), and mental health component summary score (MCS) of the questionnaire SF-36 (53.95 ± 3.47 vs. 58.33 ± 4.50, p = 0.044). Scores on the general health (77.88 ± 14.56 vs. 89.75 ± 13.76, p = 0.025) and mental health (81.50 ± 9.30 vs. 90.00 ± 11.71, p = 0.018) subscales of the SF-36 also increased significantly.ConclusionThe COVID-19 lockdown led to an increase in body composition parameters and showed an improvement in the MCS and scores on the general and mental health subscales of the SF-36. Physical performance and sleep quality could be maintained during the home training period. These observations may help trainers for future training planning during longer interruptions in soccer training.
PENGARUH PIJAT ENDORPHIN TERHADAP PENURUNAN RASA NYERI SAAT PROSES PERSALINAN
Authors: Brillianty Alifia Nanda , Pulungan Yulinda 
Published: June 2022

Persalinan adalah proses untuk mengeluarkan bayi yang ditandai dengan kontraksi pada rahim sehingga menimbulkan rasa nyeri selama proses sebelum bayi lahir. Pijat endorphin adalah terapi sentuhan/pijatan ringan yang cukup penting diberikan sebelum hingga saatnya melahirkan. Ini disebabkan karena terapi sentuhan ini membuat tubuh melepaskan senyawa endorphin yang bisa meredakan rasa sakit dan dapat menciptakan perasaan nyaman. Evidence based case report ini bertujuan untuk menganalisis hasil tindakan pemberian pijat endorphin terhadap penurunan rasa nyeri saat proses persalinan. Penelusuran artikel mengenai pengaruh pijat endorphin terhadap penurunan rasa nyeri saat proses persalinan dilakukan di ResearchGet, Portal Garuda, Crossref, dan Google Scholar. Didapatkan 1 artikel quasy experiment dengan one group pretest-posttest only oleh Wiwi Wardani Tanjung dan Adi Antoni yang sesuai dengan rancangan penelitian kecil yang akan dilakukan. Setelah ditelaah secara kritis, penelitian yang dilakukan Wiwi dan Adi dinyatakan sahih, penting, dan dapat diterapkan pada pasien. Terdapat perbedaan intensitas nyeri persalinan sebelum dan sesudah dilakukan pijat endorphin.
“Anchurosas puertas al crimen”. Discursos letrados sobre la ebriedad. Santa Fe, segunda mitad del siglo XIX
Authors: Sedrán Paula 
Published: June 2022

A lo largo de la segunda década del siglo XIX el Estado argentino resignificó prácticas antes toleradas. En el marco de la modernización social estas redefiniciones delimitaron nuevas fronteras sociales con el otro. La construcción del ebrio como amenaza se inscribió en procesos nominativos más amplios que las elites impulsaron en la pugna por imponer un nuevo orden. Involucró discusiones de índole muy amplia -causas, naturaleza del fenómeno, posibles soluciones- y abarcó discursos y prácticas interrelacionados y analíticamente reconocibles. Entendiendo estos procesos como parte de la gestación de nuevas relaciones sociales, este trabajo explora discursos sobre la ebriedad y los pone en diálogo con prácticas estatales dirigidas a controlarla, con el objetivo de indagar en los sentidos y objetivos de los discursos que se consolidaron en el período. Para ello se utilizan fuentes gubernamentales, policiales y periodísticas.
Reseñas
Authors: Talavera Viviana , Glasman Lucas , Hernández María Julia 
Published: June 2022

CASTELLANOS, Santiago, En el final de Roma (ca. 455-480): la solución intelectual, Ediciones de Historia, Marcial Pons, Madrid, 2013POY, Lucas, Los orígenes de la clase obrera; huelgas, sociedades de resistencia y militancia política en Buenos Aires 1888-1896, Imago Mundi, Buenos Aires, 2014 SCOCCO Marianela , El viento sigue soplando. Los orígenes de Madres de Plaza de Mayo de Rosario (1977-1985), Último Recurso, Rosario, 2016
ANGIOLEIOMIOMA ANAL. UNA RARA LOCALIZACIÓN.
Authors: VILLALÓN CORTÉS RICARDO ENRIQUE , Maldonado Schoijet Ignacio , Contreras Aguilera Paulina 
Published: June 2022

Hombre 55 años. Derivado desde Urología por masa anal, asintomático. Al examen anal destaca abombamiento perianal izquierdo, TR: lesión tumoral de 4 cms. de diámetro en espesor esfinteriano, semimóvil, indoloro. RM pelvis (Figura 1) describe Lesión sólida (*) centrada en el plano interesfinteriano perianal izquierdo, abomba ambos esfínteres anales, no infiltrativo. Al estudio funcional (C) y contraste endovenoso (D) exhibe acentuada restricción en difusión y realce por el contraste, que sugiere lesión hipervascular de alta celularidad. Estudio colonoscópico sin lesiones y TC Tórax, abdomen y pelvis sin evidencias de diseminación.Se realizó resección quirúrgica bajo anestesia raquídea, encontrándose masa gomosa, multilobulada, interesfinteriana no infiltrativa, siendo resecada integramente. (Figura 2,3). Evolución satisfactoria.Los hallazgos de anatomía patológica confirman un angioleiomioma.Los angioleiomiomas son tumores benignos, muy infrecuentes y solitarios, que se originan en la vasculatura del musculo liso. Se presentan en cualquier parte del cuerpo, aunque más frecuentemente en extremidades inferiores (1). La localización gastrointestinal es rarísima y en la región anorrectal constituyen el 3% de todos los tumores gastrointestinales benignos de músculos lisos (2). No hemos encontrado publicaciones en región perianal. La resección quirúrgica es el tratamiento de elección (2,3) y la malignización a leiomiosarcoma es infrecuente (4,5).
Alternative Education Strategy in The New Normal Era
Authors: Ashari Mohamad Yahya , Mahfudhoh Rifatul 
Published: June 2022

Covid 19 pandemic forces the humanbeing to change their habits and forces the teachers to innovate in their teaching. The application of approaches, methods, strategies and technics can make the students diligent in their study such as self-direct learning. The purposes of the paper are defining the strategy of Self-direct learning, the teacher role and the steps of Self-direct learning strategy. The paper uses qualitative approach by implementation of literature study and uses the procedures of miles and hubberman in data collecting and data analysis. The findings of the paper are : 1) The strategy of Self-direct learning that forces the students to upgrade the knowledge, the competence and the achievement based on personal inisiative in studying design, implementation and evaluation. 2) The strategy of Self-direct learning that forces the teacher to be the contact, supervisor and programmer in teaching. 3) The steps of Self-direct learning strategy composed of 3 (three) steps that are design, implementation and evaluation. The originality of the paper is The strategy of Self-direct learning forces the student freedom and awareness in studying. The paper type is literature study.
إن جائحة كوفيد 19 شجع الناس على تحويل سلوكهم وشجع المدرسين على الابتكار في عملية التعليم بالغرفة الدراسية. فتطبيق عدة مداخل وطرائق واسترتيجيات وتكنيكات يجعل الطلاب نشيطين في التعلم منها إستراتيجية التعليم الموجه ذاتيا. اتجهت الدراسة إلى البحث عن تعريف إستراتيجية التعليم الموجه ذاتيا ودور المدرس فيها وخطواتها في التعليم. وأصبح نوع الدراسة دراسة مكتبية نظرية، فاستخدمت الدراسة مدخل البحث الكيفي مع تطبيق منهج الدراسة المكتبية واستخدمت منهج ميلس وهوبرمان في جمع وتحليل البيانات. توصلت الدراسة إلى: (1) إن استراتيجية التعليم الموجه ذاتيا هي التي تشجع الطلاب على تنمية المعرفة والمهارة والانجاز مؤسسة على المبادرة الشخصية في تصميم التعلم وتنظيم تنفيذه وتقويمه. و(2) إن استراتيجية التعليم الموجه ذاتيا تشجع المدرس على أن يكون متصلا ومرشدا ومنظما في التعليم. و(3) إن خطوات استراتيجية التعليم الموجه ذاتيا تكونت من 3 (ثلاث) خطوات، منها: التصميم والتنفيذ والملاحظة والتقويم. الاستفادة من هذه الدراسة بأن استراتيجية التعليم الموجه ذاتيا شجعت الطلاب على الدراية والاستقلال في التعلم.