bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved CGM Glucometrics and More Visits for Pediatric Type 1 Diabetes Using Telemedicine During 1 Year of COVID-19
Authors: Kaushal Tara , Tinsley Liane J , Volkening Lisa K , Turcotte Christine , Laffel Lori M 
Published: August 2022

Abstract

Purpose
The COVID-19 pandemic led to rapid adoption of telemedicine for the care of youth with type 1 diabetes (T1D). We assessed the utility of a primarily virtual care model by comparing glucometrics from a pediatric sample with T1D using continuous glucose monitoring (CGM) both before and during the pandemic.

Methods
Pediatric patients aged 1 to 17 years with T1D duration ≥ 1 year if ≥ 6 years old or ≥ 6 months if &lt; 6 years old, with ≥ 1 visit with recorded CGM data both prepandemic (April 1, 2019-March 15, 2020) and during the pandemic (April 1, 2020-March 15, 2021) were included. Data were extracted from the electronic health record.

Results
Our sample comprised 555 young people (46% male, 87% White, 79% pump-treated), mean age 12.3 ± 3.4 years, T1D duration 5.9 ± 3.5 years, baseline glycated hemoglobin A1c 8.0 ± 1.0% (64 ± 10.9 mmol/mol). Diabetes visit frequency increased from 3.8 ± 1.7 visits/prepandemic period to 4.3 ± 2.2 visits/pandemic period (P &lt; 0.001); during pandemic period, 92% of visits were virtual. Glucose management indicator (GMI) improved slightly from 7.9% (63 mmol/mol) prepandemic to 7.8% (62 mmol/mol) during the pandemic (P &lt; 0.001). Those with equal or greater visit frequency (n = 437 [79% of sample]) had significant improvement in GMI (8.0% to 7.8% [64 to 62 mmol/mol], P &lt; 0.001), whereas those with lower visit frequency did not (7.8 [62 mmol/mol], P = 0.86).

Conclusions
Children and adolescents with T1D using CGM before and during the pandemic showed an overall increase in visit frequency using primarily telemedicine-based care and improved CGM glucometrics. Further research is needed to understand factors associated with successful use of telemedicine for pediatric T1D.
Liver Abnormalities in Turner Syndrome: The Importance of Estrogen Replacement
Authors: Fedor Istvan , Zold Eva , Barta Zsolt 
Published: August 2022

AbstractTurner syndrome is one of the most frequently reported sex chromosomal abnormalities, affecting approximately 40 in every 100 000 live female births. The underlying chromosomal alteration is the complete or partial loss of X chromosome or mosaicism. Because of primary ovarian insufficiency, the synthesis of estrogen hormones is compromised, and patients require hormone substitution. Apart from the phenotypical presentation (short stature, primary amenorrhea), the effects of ovarian insufficiency can affect diverse organ systems (such as cardiovascular, endocrine, and lymphatic systems). Hepatobiliary pathology can present on a broad spectrum: from mild asymptomatic hypertransaminasemia to marked architectural changes. Estrogen hormone replacement therapy in these patients can improve the perturbations of laboratory values and can attenuate the progression of hepatic structural changes. Moreover, providing sufficient estrogen replacement has numerous benefits for other conditions of the patients as well. Both the all-cause mortality and deaths from cardiovascular complications are greatly increased in Turner syndrome, and hormone replacement might contribute to the decreased incidence of these events. The diagnostics of Turner syndrome are outside the scope of our paper, and we briefly discuss the cardiovascular complications because many the liver involvement partially involves alterations of vascular origin. Though we sought to highlight the importance of proper hormone replacement therapy, we did not attempt to write a comprehensive recommendation for exact treatment protocols. We provided an overview of preferred therapeutic approaches, as the treatment should be tailored according to the individual patient’s needs.
Efficacy of Preoperative Oral Midodrine in Preventing Hypotension After Spinal Anesthesia in Young Adults: A Randomized Controlled Trial
Authors: Alseoudy Mahmoud Mohammed , Nasr Mohamed Osama , Abdelsalam Tamer Ahmed 
Published: August 2022

BACKGROUND:
Midodrine was effectively used for prophylaxis against hypotensive syndromes such as postural hypotension and intradialytic hypotension, and during the recovery phase of septic shock. In our study, we aimed to assess the efficacy of prophylactic administration of midodrine tablets before spinal anesthesia in reducing the occurrence of hypotension.

METHODS:
This randomized placebo-controlled study embraced 67 patients aged 18 to 40 years undergoing elective knee surgery under spinal anesthesia. Patients were randomized to midodrine group (given 10-mg tablets of midodrine) or placebo group (given placebo tablets), and tablets were administered 1 hour before spinal anesthesia (intrathecal injection of 12.5-mg 0.5% hyperbaric bupivacaine and 15-μg fentanyl). The primary outcome was the occurrence of hypotension, defined as a systolic blood pressure <90 mm Hg or <80% of baseline. Secondary outcomes were hemodynamic characteristics (mean arterial pressure [MAP] and heart rate [HR]) after spinal anesthesia, ephedrine dose, and occurrence of complications including bradycardia, vasovagal attacks, reactive hypertension nausea, vomiting, and shivering.

RESULTS:
The number of patients who became hypotensive after spinal anesthesia was 5 (14.7%) in midodrine group versus 14 (42.4%) in the placebo group; relative risk (95% confidence interval) was 0.35 (0.14–0.85) (P = .021). The median (interquartile range) total dose of ephedrine was significantly lower in midodrine group 0 (0–10) mg than in placebo group (0 (0–15) mg; the Hodges-Lehmann median difference (95% confidence interval) was 0 (0–5) mg (P = .015). For MAP data, the group × time interaction was significant (P = .038), and the MAP was significantly lower in the placebo group than in the midodrine group after intrathecal injection at 2 minutes (P = .047), 10 minutes (P = .045), 15 minutes (P < .001), 20 minutes (P = .007), 30 minutes (P =.013), 45 minutes (P = .029), 60 minutes (P = .029), and at the end of surgery (P < .001). For HR data, the group × time interaction was nonsignificant (P = .807), and the difference in means (95% confidence interval) between groups collapsing over time was −1.4 (−3.1 to 0.2) beats/min (P = .096). There was no significant difference between the 2 groups regarding the occurrence of complications.

CONCLUSIONS:
Prophylactic administration of 10-mg midodrine tablets before spinal anesthesia is an effective method in the prevention of hypotension in young adult patients undergoing elective orthopedic knee surgery.
Climbing the Obelisk: The Trajectories of Five Women Economists in Colombia, ca. 1950–70
Authors: Guiot-Isaac Andrés , Espinel Camila Orozco 
Published: August 2022

Abstract
This article explores the trajectories of the first Colombian women economists. It sheds light on how differences between women's and men's experiences structured the process of becoming and working as economists and more generally the professional development of economics in the country. The article focuses on the trajectories of five women who graduated between the 1950s and the early 1970s and who had exceptionally successful careers. It shows how the late professionalization of economics in Colombia and access to international credentials created specific opportunities and challenges for women economists. During their professional trajectory, the group of women who constitute the focus group of this article resorted to a mix of professional strategies, which included mobilizing resources by securing the support of male figures, such as fathers and mentors; striking a balance between showing an intrepid character and developing a sense of pragmatism; and delegating part of the care and domestic tasks that were expected from them as wives and mothers to other women less endowed with economic, social, and academic capital.
“When It's Dark in the East, It's Light in the West”: Lifelong Venturing and Accelerated Temporality in Beijing's Urban Villages
Authors: Zhan Yang 
Published: August 2022

AbstractFor decades, Chinese rural migrants have been understood as engaging in dagong 打工 (working for a boss), or the selling of their waged labor, conditioned by the global production chain, dormitory regimes, and exploitive labor relations within and beyond factories. Meanwhile, chuangdang 闯荡 (venturing) as a life project that either opposes or extends dagong has been neglected in scholarly studies. Venturing refers to a spatiotemporal condition defined by the uniqueness of urban villages where rural migrants participate in the informal economy on the urban fringes and attach themselves to entrepreneurship and mobility. It is also a multifaceted presentism produced out of the following spatiotemporal conditions: (1) the sense of urgency to get ahead in spatial temporality; (2) an optimistic relationship with unpredictability; and (3) the technologies of mobility in the name of freedom. By highlighting the dilemmas that propel and hinder rural migrants, this article argues that the cultural politics of venturing are a condition that renders rural migrants economically aggressive, yet politically passive. Thereby, it not only prolongs rural migrants’ mobile lives on the urban fringes, but also dampens political actions that claim space through resistance.
A cross-sectional analysis identifies a low prevalence of Plasmodium ovale curtisi infections in symptomatic and asymptomatic individuals in Kilifi county, Kenya.
Authors: Akinyi Mercy Yvonne , Chifwete Margaret , Ndwiga Leonard , Kimenyi Kelvin Muteru , Osoti Victor , Ochola-Oyier Lynette Isabella 
Published: August 2022

Background: The focus on P. falciparum diagnosis has led to an underestimation of the global burden of malaria resulting from neglected Plasmodium species. However, there is still scarce data on the prevalence of P. ovale globally. To address this knowledge gap, data collected from cross-sectional studies in Kilifi county were used to: 1) determine the prevalence of P. ovale curtisi infections; and 2) determine the sensitivity of different diagnostic assays in detecting P. ovale curtisi infections. Methods: A total of 531 individuals were sampled across three study sites in Kilifi County, Kenya between 2009 and 2020. Blood smears were prepared from peripheral blood and screened for Plasmodium parasite stages using light microscopy. Molecular screening involved DNA extraction of dried blood spots and blood in ethylenediaminetetraacetic acid, polymerase chain reaction (PCR) using primers targeting the 18 small ribosomal subunit and sequencing. Results: Microscopy screening revealed that the most prevalent species was P. falciparum (32.0%) followed by P. malariae (9.0%) and then P. ovale (1.5%). PCR screening identified additional P. ovale curtisi positives cases. Overall, 48 (8.2%) out of the 531 individuals harbored P. ovale curtisi infection with the highest prevalence reported in the tertiary health facility, (14.6%, 95% CI 8-23.6%), followed by the primary health facility (8.6%, 95% CI 5.4-11.9%), and the community from a cross-sectional blood survey, (6.5%, 95% CI 3.0-11.8%). Microscopy screening for P. ovale had a low sensitivity of 7% (95% CI 1-19-30%) and a high specificity of 99% (95% CI 98-100%). Sequencing results confirmed the presence of P.ovale curtisi. Conclusions: This study provides baseline data for P.ovale curtisi surveillance in Kilifi County, primarily using PCR to improve diagnosis. These results suggest that malaria elimination and eradication efforts should not only concentrate on P. falciparum but should embrace a holistic approach towards elimination of all Plasmodium species.
Underwater optical guiding and communication solution for the AUV and
seafloor node
Authors: Chen Yanhu , Duan Zhiyong , Zheng Fangzhou , Guo Yuteng , Xia Qingchao 
Published: August 2022

In this paper, an optical guiding and docking scheme is designed, and a node integrating laser positioning guidance and communication functions is developed. Through experiments, it is verified that the laser docking system has the function of guiding and communicating the autonomous underwater vehicle (AUV) with the support of the seabed observation network. It can provide two-dimensional position information for underwater platforms to navigate the media to sea network nodes and enable visual contact between them. The integrated terminals are small enough (6 cm in diameter) to be installed on small underwater platforms, such as AUVs. To safely work at a depth of thousands of meters, the devices have cylindrical shapes rather than spherical shapes. However, the cylindrical shell confines the view angle of the receiver. An optical system and a photodiode array are adopted to enlarge the cylindrical-shaped receiver’s view angle. The positioning algorithm is designed based on the optical lens system and the photodiode array. In a small-pool experiment, this system is tested to achieve a data rate of 1 Mbit/s at a distance of 4 m. Positioning algorithms are also confirmed preliminarily in the small-pool experiment, and the error of the positioning algorithm is discussed.
Enhancement of the frequency conversion film imaging effect based on a cascade material fusion method
Authors: Zhou Jianwei , Cai Hongxing , Ren Yu , Li Shuang , Jiang Chunxu , Lv Zhong , Wang Tingting , Qu Guannan , Tan Yong , Shi Jing , Xin Minsi , Miao Xinhui , Liu Quansheng 
Published: August 2022

Frequency conversion imaging technology can provide an effective way for infrared detection against the limitations of conventional infrared detectors, such as expense and cooling requirements, but the converted luminescence intensity of frequency conversion materials limits the application of this technology. In this paper, a cascade material (CM) fusion method is proposed to improve the conversion luminous intensity and thus enhance the frequency conversion imaging effect at 1550 nm near infrared (NIR) excitation. First, we derived from the energy level transition mechanism of CM that the CM fusion method can achieve three excitations of substrate materials (SMs). It can improve the conversion luminescence intensity of SM in CM. Then, we experimentally prepared CM and SM films and simultaneously measured the frequency conversion imaging effect of the two films at 1550 nm NIR excitation. It was found that the weight ratio of doped material (DM) to SM affects the imaging enhancement of CM films. Therefore, we compared the imaging grayscale value intensity of CM films with different weight ratios under the same detection conditions. Finally, it was concluded that the best enhancement of frequency conversion imaging was achieved with a DM to SM weight ratio of 0.25 for this mechanism. The enhancement was about 3.11 times compared to SM films.
A scoping review of Do-It-Yourself Automated Insulin Delivery system (DIY AID) use in people with type 1 diabetes
Authors: Morrison Amy E. , Chong Kimberley , Senior Peter A. , Lam Anna 
Published: August 2022

Introduction
User designed Automated Insulin Delivery systems (AID), termed Do-It-Yourself (DIY) AID include; AndroidAPS, OpenAPS and Loop. These unregulated systems provide challenges for healthcare providers worldwide, with potential legal and ethical barriers to supporting their use. We performed a scoping review of the currently available literature surrounding DIY AID systems, specifically to highlight the evidence available to facilitate healthcare providers to support persons with diabetes who may benefit from DIY AID.

Methods
Studies relating to DIY AID systems were searched in Embase, Medline, Web of Science, Scopus, Proquest and Cochrane library until 31st December 2021. Publications were screened through title and abstract to identify study type and AID system type described. A thematic synthesis methodology was used for analysis of studies of DIY AID use due to the heterogeneity in study designs (case reports, qualitative, cross-sectional and cohort studies), with similarity in outcome themes.

Results
Following implementation of the search strategy, 38 relevant full texts were identified; comprising 12 case reports, 9 qualitative studies and 17 cohort studies, and data was also available from 24 relevant conference abstracts. No randomized studies were identified. Common themes were identified in the outcomes across the studies; glycemic variability, safety, quality of life, healthcare provider attitudes and social media.

Conclusion
There is extensive real-world data, but a lack of randomized control trial evidence supporting DIY AID system use, due to the user-driven, unregulated nature of these systems. Healthcare providers report a lack of understanding surrounding, and confidence in supporting, DIY AID despite impressive observational and user self-reported improvements in glycemic variability, without any reported safety compromises.
The proportion of loss to follow-up from antiretroviral therapy (ART) and its association with age among adolescents living with HIV in sub-Saharan Africa: A systematic review and meta-analysis
Authors: Leshargie Cheru Tesema , Demant Daniel , Burrowes Sahai , Frawley Jane 
Published: August 2022

Background
Human immunodeficiency virus (HIV) remains a global health threat, especially in developing countries. The successful scale-up of antiretroviral therapy (ART) programs to address this threat is hindered by a high proportion of patient loss to follow-up (LTFU). LTFU is associated with poor viral suppression and increased mortality. It is particularly acute among adolescents, who face unique adherence challenges. Although LTFU is a critical obstacle on the continuum of care for adolescents, few regional-level studies report the proportion of LTFU among adolescents receiving ART. Therefore, a systematic review and meta-analysis were conducted to estimate the pooled LTFU in ART programs among adolescents living with HIV in sub-Saharan Africa (SSA).

Methods
We searched five databases (PubMed, Embase (Elsevier), PsycINFO, CINAHL, and Scopus) for articles published between 2005 and 2020 and reference lists of included articles. The PRISMA guidelines for systematic reviews were followed. A standardised checklist to extract data was used. Descriptive summaries were presented using narrative tables and figures. Heterogeneity within the included studies was examined using the Cochrane Q test statistics and I2 test. Random effect models were used to estimate the pooled prevalence of LTFU among ALHIV. We used Stata version 16 statistical software for our analysis.

Results
Twenty-nine eligible studies (n = 285,564) were included. An estimated 15.07% (95% CI: 11.07, 19.07) of ALHIV were LTFU. Older adolescents (15–19 years old) were 43% (AOR = 0.57, 95% CI: 0.37, 0.87) more likely to be LTFU than younger (10–14 years old) adolescents. We find an insignificant relationship between gender and LTFU (AOR = 0.95, 95% CI: 0.87, 1.03). A subgroup analysis found that regional differences in the proportion of adolescent LTFU were not statistically significant. The trend analysis indicates an increasing proportion of adolescent LTFU over time.

Conclusions and recommendations
The proportion of LTFU among HIV-positive adolescents in SSA seems higher than those reported in other regions. Older adolescents in the region are at an increased risk for LTFU than younger adolescents. These findings may help policymakers develop appropriate strategies to retain ALHIV in ART services. Such strategies could include community ART distribution points, appointment spacing, adherence clubs, continuous free access to ART, and community-based adherence support.
Numerical Investigation of a New Modified Savonius Wind Turbines
Authors: Mrigua Khalid , Zemamou Mounia , Aggour Mohammed 
Published: August 2022

The classic Savonius semi-circular blade turbine has a relatively low power coefficient.The performance of a Savonius wind turbine depends on its geometrical parameters. Various blade profiles have been developed in the past years to improve the performance of this class of turbine. In this paper, a new blade shapes of Savonius wind turbine is investigated numerically by using the CFD method , by using transient conditions and set k omega turbulence model.The new blade has different concave and convex shape, which is a combination of the conventional and the elliptical blade. A comparative study of three blade profiles, semi-circular, elliptical and the composed blades have been performed.Flow structures around the rotor have also been analyzed. The results show that changing the blade shape has an effect on the performance efficiency of the Savonius turbine.The new modified and the elliptical blade exhibit higher performance compared to the conventional Savonius wind turbine. The new modified Savonius blade and the elliptical blade exhibit an improved performance compared to the conventional model in the order of 20.5% and 18.2% respectively at the tip speed ratio of 0.8.
A contrastive ecological discourse analysis of the General Debate statements by the US and China at the United Nations General Assembly (2017–2020)
Authors: Ma Chen , He Wei 
Published: August 2022

Abstract
This article adopts an ecolinguistic approach to study the thematic choices in the General Debate statements by the US and China at the United Nations General Assembly (2017–2020) to reveal the eco-characteristics of the two countries’ thematic choices and their impacts on the constructions of international relations. Findings suggest that, from the perspective of ecosophy, a significant proportion of the US’s thematic choices are destructive to international relations, while China’s thematic choices are mostly beneficial and ambivalent. The US’s thematic choices are frequently used to portray “us versus them” and “America first”, which displays a message of egocentrism instead of ecocentrism. China’s thematic choices are typically used to show China’s willingness to undertake global responsibility and to jointly work with other stakeholders to safeguard our planet, echoing China’s global vision of “building a shared future for mankind”.
Molecular mechanisms defining penetrance ofLRRK2-associated Parkinson’s disease
Authors: Trinh Joanne , Schymanski Emma L. , Smajic Semra , Kasten Meike , Sammler Esther , Grünewald Anne 
Published: August 2022

AbstractMutations inLeucine-rich repeat kinase 2(LRRK2) are the most frequent cause of dominantly inherited Parkinson’s disease (PD).LRRK2mutations, among which p.G2019S is the most frequent, are inherited with reduced penetrance. Interestingly, the disease risk associated withLRRK2G2019S can vary dramatically depending on the ethnic background of the carrier. While this would suggest a genetic component in the definition ofLRRK2-PD penetrance, only few variants have been shown to modify the age at onset of patients harbouringLRRK2mutations, and the exact cellular pathways controlling the transition from a healthy to a diseased state currently remain elusive. In light of this knowledge gap, recent studies also explored environmental and lifestyle factors as potential modifiers ofLRRK2-PD. In this article, we (i) describe the clinical characteristics ofLRRK2mutation carriers, (ii) review known genes linked toLRRK2-PD onset and (iii) summarize the cellular functions ofLRRK2with particular emphasis on potential penetrance-related molecular mechanisms. This section coversLRRK2’s involvement in Rab GTPase and immune signalling as well as in the regulation of mitochondrial homeostasis and dynamics. Additionally, we explored the literature with regard to (iv) lifestyle and (v) environmental factors that may influence the penetrance ofLRRK2mutations, with a view towards further exposomics studies. Finally, based on this comprehensive overview, we propose potential futurein vivo,in vitroandin silicostudies that could provide a better understanding of the processes triggering PD in individuals withLRRK2mutations.