bluuebunny/crossref_metadata_2025_split huggingface dataset:
TIC como herramientas didácticas para el profesorado de educación física en la formación reglada utilizando el modelo Flipped Classroom
Authors: Espejo García R. , Infantes Rojas B. , Moya Medina M.A. , Morente-Oria H. 
Published: January 2022

ICTs are tools present in our life's areas, the rise of which has led to their introduction in the educational curriculum and in teaching as a key and indispensable part of it. Thanks to scientific advancement, performance measurement devices are becoming more frequent and easy to use by professionals in physical activity and sports. Therefore, the present work aims to make a didactic proposal based on the use of ICT as a methodological strategy and tool for assessing and implementing training programs within the curricular framework of the educational stage Professional Training of the Higher Technician in Physical Conditioning. This proposal will consist of seven sessions for the subject of "Assessment of the physical condition and intervention in accidents" where they will handle digital tools that favor developing their objectives and skills and integration into the professional market.
Las TIC son una herramienta presente en todos los ámbitos de nuestra vida, cuyo auge ha provocado su introducción en el currículum educativo y en las enseñanzas como una pieza clave e indispensable del mismo. Gracias al avance científico, el uso de dispositivos para la medición del rendimiento es cada vez más frecuente y fácil de usar por parte de profesionales de la actividad física y del deporte. Por eso, el presente trabajo tiene como objetivo realizar una propuesta didáctica basada en el uso de las TIC como estrategia metodológica y herramienta para la valoración y realización de programas de entrenamiento dentro del marco curricular de la etapa educativa Formación Profesional del Técnico Superior en Acondicionamiento Físico. Esta propuesta estará compuesta por siete sesiones para la asignatura de “Valoración de la condición Física e intervención en accidentes” donde manejarán herramientas digitales que favorezcan el desarrollo de sus objetivos y competencias e integración en el mercado profesional.
Genome-wide identification and expression profile of YABBY genes in Averrhoa carambola
Authors: Li Chengru , Dong Na , Shen Liming , Lu Meng , Zhai Junwen , Zhao Yamei , Chen Lei , Wan Zhiting , Liu Zhongjian , Ren Hui , Wu Shasha 
Published: January 2022

Background
Members of the plant-specific YABBY gene family are thought to play an important role in the development of leaf, flower, and fruit. The YABBY genes have been characterized and regarded as vital contributors to fruit development in Arabidopsis thaliana and tomato, in contrast to that in the important tropical economic fruit star fruit (Averrhoa carambola), even though its genome is available.

Methods
In the present study, a total of eight YABBY family genes (named from AcYABBY1 to AcYABBY8) were identified from the genome of star fruit, and their phylogenetic relationships, functional domains and motif compositions, physicochemical properties, chromosome locations, gene structures, protomer elements, collinear analysis, selective pressure, and expression profiles were further analyzed.

Results
Eight AcYABBY genes (AcYABBYs) were clustered into five clades and were distributed on five chromosomes, and all of them had undergone negative selection. Tandem and fragment duplications rather than WGD contributed to YABBY gene number in the star fruit. Expression profiles of AcYABBYs from different organs and developmental stages of fleshy fruit indicated that AcYABBY4 may play a specific role in regulating fruit size. These results emphasize the need for further studies on the functions of AcYABBYs in fruit development.
Metabolomics of a cell line-derived xenograft model reveals circulating metabolic signatures for malignant mesothelioma
Authors: Gao Yun , Dai Ziyi , Yang Chenxi , Wang Ding , Guo Zhenying , Mao Weimin , Chen Zhongjian 
Published: January 2022

Background
Malignant mesothelioma (MM) is a rare and highly aggressive cancer. Despite advances in multidisciplinary treatments for cancer, the prognosis for MM remains poor with no effective diagnostic biomarkers currently available. The aim of this study was to identify plasma metabolic biomarkers for better MM diagnosis and prognosis by use of a MM cell line-derived xenograft (CDX) model.

Methods
The MM CDX model was confirmed by hematoxylin and eosin staining and immunohistochemistry. Twenty female nude mice were randomly divided into two groups, 10 for the MM CDX model and 10 controls. Plasma samples were collected two weeks after tumor cell implantation. Gas chromatography-mass spectrometry analysis was conducted. Both univariate and multivariate statistics were used to select potential metabolic biomarkers. Hierarchical clustering analysis, metabolic pathway analysis, and receiver operating characteristic (ROC) analysis were performed. Additionally, bioinformatics analysis was used to investigate differential genes between tumor and normal tissues, and survival-associated genes.

Results
The MM CDX model was successfully established. With VIP > 1.0 and P-value < 0.05, a total of 23 differential metabolites were annotated, in which isoleucine, 5-dihydrocortisol, and indole-3-acetamide had the highest diagnostic values based on ROC analysis. These were mainly enriched in pathways for starch and sucrose metabolism, pentose and glucuronate interconversions, galactose metabolism, steroid hormone biosynthesis, as well as phenylalanine, tyrosine and tryptophan biosynthesis. Further, down-regulation was observed for amino acids, especially isoleucine, which is consistent with up-regulation of amino acid transporter genes SLC7A5 and SLC1A3 in MM. Overall survival was also negatively associated with SLC1A5, SLC7A5, and SLC1A3.

Conclusion
We found several altered plasma metabolites in the MM CDX model. The importance of specific metabolic pathways, for example amino acid metabolism, is herein highlighted, although further investigation is warranted.
Morphological, Physical and Biochemical Characteristics of the three Main Varieties of Mango (Mangifera indica L.) Cultivated in the Poro Region (North of Côte d'Ivoire)
Authors: Serge Guédé Séri , Mélanie Adombi Caroline , Abdoulaye Touré 
Published: January 2022

Mango processing in Côte d'Ivoire is limited by data failure on characteristics of mango varieties. The purpose of this work is to contribute to the valorization of the main varieties of mango (Amelie, Kent and Keitt) cultivated in Côte d'Ivoire through the evaluation of their morphological, physical and biochemical parameters.
Between May and June 2020, ten ripe fruits of each variety were randomly selected from ten batches of mangoes from different producers in the Poro region. After sampling, morphological, physical and biochemical parameters were determined at the biochemistry - microbiological laboratory of Peleforo Gon Coulibaly University in the month of June 2020.
This study showed that the mangoes Kent and Amelie were bigger than those of Keitt. However, when ripe, the three mango varieties studied had each a specific gravity close to 1 g/cm3; they could therefore float on water. They were elongated in shape and corresponded to the caliber group B of mangoes exportable to the European market. The high values of pulp proportions (82.70 to 83.62%), pulp/stone ratios (12.71 to 13.33) and waste indices (4.69 to 5.20) gave them interesting aptitudes for industrial processing. With high moisture contents (77.80 to 84.80%), low fiber contents (0.53 to 0.84%) and acidity values (0.20 to 0.50%), interesting ascorbic acid contents (45.02 to 46.25 mg/100g ), TSS contents (15.51 to 18.50 °Brix) conforming to standard for fruit juices and nectars, the mango varieties studied would be suitable for making puree, juice or ice cream. However, with a higher sugars/acidity ratio (73.46), mango variety Kent would be more suitable for drying and making frozen or canned mango pieces; while those of Amelie and Keitt would be suitable for the manufacture of purees, concentrates and drinks.
The results of this study could guide processors in the choice of varieties according to the types of derived products. They are interesting and should be deepened by including other varieties (improved and local) cultivated in Côte d'Ivoire.
Protective Role of Different Local Spices on Lambda Cyhalothrin Induced Nephrotoxicity in Male Mice
Authors: Orlu Eme Efioanwan , Obulor Adetutu Olubunmi 
Published: January 2022

Aim: This study was aimed at evaluating the protective role of different local spices on lambda cyhalothrin induced nephrotoxicity in male mice
Experimental Design: A completely randomized experimental design using standard methods for analysis.
Place and Duration of Study: This study was carried out in the Animal house, Department of Animal and Environmental Biology of Rivers State University, Nkpolu-Oroworukwo Port Harcourt, Nigeria. GPS 4o47'50''N 6o58'49''E. This study lasted for 35days.
Methodology: The experimental animals were separated into 6 groups (A-F) of seven mice each. Group A served as the control and Group B – F served as the test groups. At the end of the 35 day treatment period, feed was withdrawn from the mice 24 hours before termination of the experiment. Blood samples for analysis of kidney function test were collected from each mouse by ocular puncture into plain tubes. The blood was allowed to clot and centrifuged at 2500g to separate the serum from the cells. Total protein was analyzed using the spectrophotometric method of biuret, Bradford and erythrosine – b, albumin was estimated, creatinine and urea was done using enzymatic method. Vital organs were removed and weighed for organosomatic indices. Histological sections of the kidney were mounted on slides, stained with hematoxylin and eosin (H&E). Photomicrographs were generated.
Results: There is no significant difference (P=0.05) between the organ weight and bodyweight in group A compared with the treatment groups. The values of Albumin, total protein, urea, creatinine and total bilirubin increased significantly in group B administered lambda cyhalothrin alone but decreased in groups administered the local spices. Histopathological analysis of the kidney shows the regular structure of the kidney architecture in group A, tubular degeneration and several vacuolations were observed in group B. However, less degeneration of the epithelial cells, regeneration of renal tubular epithelium were observed in groups C- F.
Conclusion: Based on the results from liver biomarkers and histological micrographs from this study, pronounced degeneration was observed in the kidney cells exposed to lambda-cyhalothrin only. Moreover, all spices used had a regenerating ability on the kidney tubules. It is advocated therefore that consumption of this spices either singly or in combination should be encouraged especially for those exposed to insecticides poisoning
Thyroid Disorders and Diabetes Mellitus: Prevalence and Assosciation
Authors: Hafez Ahmed Mai Hassan , Elmageed Mohammed Rasha Mohammed Abd 
Published: January 2022

Background: Diabetes mellitus and thyroid dysfunction are closely related. Numerous studies have reported an increased prevalence of thyroid disorders in diabetic patients, especially in type 1 diabetes mellitus.
Objectives: Therefore, the purpose of this review is to discuss the numerous underlying mechanisms behind the relationship between diabetes mellitus and thyroid dysfunction in order to demonstrate that the correlation between these two prevalent conditions is unlikely to be a coincidental finding.
Review: Diabetes and Thyroid disorders are characterized by endocrine system dysfunction. Thyroid hormones influence glucose metabolism in different ways, for example, they increase absorption of glucose from the gut, increase GLUT-2 level, regulate energy balance, and cause increased lipolysis which ultimately raises glucose levels in the body. Furthermore, thyroid hormones interact with adiponectin, leptin, ghrelin, to affect glucose metabolism. Additionally, studies suggest that hyperthyroidism impairs diabetic glycemic control, whereas hypothyroidism increases the risk of hypoglycemia, further complicating diabetes management.
Conclusion: This paper emphasizes thyroid abnormalities, if left untreated, can raise the risk of several diabetes complications including retinopathy, neuropathy, and nephropathy, and can worsen diabetic symptoms. As a result, treating subclinical hypothyroidism or hypothyroidism in diabetic individuals can be advantageous. Therefore, a systematic method for early thyroid testing in diabetic patients to avoid severe complications is highly recommended.
Livelihood Challenges and Mitigation Strategies Adopted During COVID-19 Lockdown Period
Authors: Daniel Lelith , Gupte Rajani , Gore Manisha , Barve Samir , Shikalgar Shirin , Pathak Revathi , Saraf Abhay 
Published: January 2022

Over the past century, apart from COVID-19, human civilization has seen five other significant pandemics such as the H1N1 outbreak in 2009, Ebola outbreak in West Africa in 2014, and subsequent outbreak in Congo in 2019, Zika outbreak in 2016, etc. However, of all these outbreaks, perhaps the COVID-19 pandemic is unparalleled due to the global proportions that it has assumed. The severity of the epidemic can be seen in terms of the number of lives lost and the multi-dimensional impact that COVID-19 has had upon the economies of nations and lives of people. Beyond the physical sphere of human life, COVID-19 has also impacted human life's social, mental, and economic aspects.
This study was conducted to understand the livelihood challenges faced by the residents of 5 villages in Mulshi taluka during the lockdown period. In-depth interviews were conducted with three respondents from each village (15 respondents). The study drew upon the insights given by key opinion leaders in the towns such as Sarpanch and elected members of the gram panchayat, ASHA workers, ration shop owners etc. Identify the livelihood challenges faced by the people during the lockdown imposed due to COVID-19. Describe the strategies adopted by the people to overcome the challenges to livelihood faced by the people.
The residents of the village's studies faced various challenges related to agriculture such as lack of manpower to harvest produce, lack of transportation facilities to transport produce to markets, lack of storage facilities to store agricultural produce etc, loss of employment faced by daily wage laborers due to non-operational status of small businesses during the lockdown period and challenges due to reverse migration.
Level of Awareness and Knowledge of Folic Acid Intake among Women in the Reproductive Age in ARAR Region, Saudi Arabia
Authors: Alanazi Abdulrahman Mazki , Alanazi Abdullah Juayf , Alanazi Yasir Wadi , Alanazi Muhammad Sari , Rezk Ghada , Hammad Sabry Mohamed 
Published: January 2022

Background: Folic acid reduces the risk of neural tube defects. As approximately 50% of pregnancies are unintended, women of reproductive age should be aware of the importance of folic acid. This study aims to assess the level of awareness and knowledge among childbearing female on the importance of preconception folic acid supplementation in preventing neural tube defects (NTDs) in Arar city.
Methodology: A population-based cross-sectional study was conducted in Arar city, Norther Saudi Arabia on included Saudi women in reproductive age. A pre-designed online questionnaire was used for data collection. Data was entered and analyzed using statistical package for Social Sciences Program, version 20 (SPSS Inc., Chicago, Illinois, USA). The results were displayed as counts, percentages. Appropriate statistical tests will be used for comparisons. P ≤ 0.05 is considered significant.
Results: The sample consisted of 428 women in reproductive age, 60.1% aged between 30 to 40 years, 39% aged between 20 to 30 years and only 0.9% aged between 18 to 20 years old. 91.8% were married. 85% of participants reported that their doctor prescribed folic pills for them before. 95.1% think that women should take folic acid pills in pregnancy while 75.2% think that it is necessary to take folic pills pre-pregnancy. 85.3% had taken folic acid pills in previous pregnancy. 31.3% think that it should be stopped after pregnancy. 84.6% think that folate deficiency causes fetal abnormalities. Only 8.4% of studied women reported attending seminar or lecture on folic acid importance.
Conclusion: The results of the current study affirmed good knowledge of folic acid supplementation usage during pregnancy among women in Arar, KSA. There was a significant association between knowledge of folic acid taking importance during pregnancy with marital status, number of children, and educational level of participants.
To Impact of Vit-D in Pulmonary Tuberculosis Patients Receiving DOTS
Authors: Bhadarge Gangaram , Hadke Saurabh , Bhatt Neha , Kaple Meghali 
Published: January 2022

Introduction: Vitamin D, also known as calciferol, is a fat-soluble vitamin that helps regulate bone metabolism and calcium homeostasis in humans. Vitamin D from the skin and right is passed on by the liver to 25-hydroxyvitamin D (25 (OH) D, which is used to assess a patient's vitamin D status. The enzyme 25-hydroxyvitamin D-1hydroxylase converts 25 (OH) D into 1, 25-dihydroxy vitamin D (1,25 (OH) 2 D) in the kidneys. Vitamin D is essential for good health. Turning the immune system to the host (MTB). Cathelicidin, an anti-bacterial peptide that prevents mycobacterium from replicating macrophages, shown to be stimulated by vitamin D. In cases of tuberculosis, high levels of serum vitamin D and hypocalcaemia. Enhanced macrophages may be blamed for high calcitriol levels in granulomas. Low levels of vitamin D, on the other hand, linked and tuberculosis (PTB) in several studies conducted worldwide.
Aim: Study of Vit-D In Pulmonary Tuberculosis Patients Receiving treatment.
Materials and Methods: This study included 40 newly diagnosed PTB patients of both sex with the age group of 18-60. The patients were comprised before and after the DOTS therapy. Time period of this study were from September 2020 to Арril 2021 а nоn-rаndоmised соntrоlled trial.
Results: The weight of patients before DOTS was decreased as compare to the weight after DOTS. The level of vitamin D significantly raised in newly diagnosed PTB patients while the vitamin D level was decreased after DOTS therapy.
Conclusion: Decreased level of vit-D in the blood can be linked to an increased risk of tuberculosis. As a result, serum Vit-D levels in TB patients can be necessary to control, as Vit-D deficiency may develop without symptoms and intensify once TB therapy starts.
Comparative Study of Combination of Oral Tranexamic Acid with Modified Kligman’s Formula Versus Oral Tranexamic Acid with Azelaic Acid 15% in the Treatment of Melasma
Authors: Singh Riddhima , Maheshwari Praveen 
Published: January 2022

Background: Melasma refers to acquired hyper-pigmentary condition effecting skin. Owing to its multifactorial causation and chronicity, there is an increased need for new multimodality therapies to treat melasma more effectively and to prevent the side effects seen with the conventional modalities of treatment.
Objectives: Compare efficacy of combining oral Tranexamic Acid and Azelaic Acid 15% with that of Oral Tranexamic Acid (TA) and Modified Kligman’s Formula. Also, to record any adverse effects of combining these agents.
Methods: Patients having Melasma who will be coming to Dermatology OPD, AVBRH, Sawangi, Wardha, will be enrolled after considering the various inclusion and exclusion criteria. A detailed history will be asked, which will be followed by a cutaneous examination that includes the calculation of MASI (Melasma Area and Severity Index).
One Group (A) - participants will receive - Oral 500 mg Tranexamic acid OD plus Modified Kligman’s Formula (fluocinolone acetonide 0.01%, tretinoin 0.05%, and hydroquinone 2%) cream one time at night only.
Second Group (B)- participants will receive - Oral 500 mg Tranexamic Acid OD plus Azelaic Acid 15% gel once daily at night only.
Both groups will also receive Broad-spectrum sunscreen SPF-30 daily (3 hourly).
Patients will be called for regular follow up at 4 weeks and 8 weeks (for early results). Clinical photos will be clicked at every follow-up visit and MASI score shall be doocumented.
Expected Results: To analyze efficacy of combining Oral TA along with Azelaic Acid 15% and if it provides better results, we can avoid the undesirable side effects that are seen on prescribing the Modified Klingman’s Formula, in Melasma patients.
Conclusion: This study will help us in analyzing efficacy of combining Oral TA with Azelaic Acid 15%, therefore will provide a newer treatment modality with lesser side effects and maybe better results than the gold standard- Modified Klingman’s Formula.
A Case Report on Acute Necrotizing Pancreatitis and Nursing Management
Authors: Shiwarkar Vaishnavi , Raut Arati , Ankar Ruchira , Sakharkar Sheetal , Wawre Sonali 
Published: January 2022

Introduction: Necrotizing pancreatitis (NP) is a health problem in which part of pancreas dies. This is because of inﬂammation or injury. If the dead tissue gets infected, it can cause serious issues. Pancreatitis is inﬂammation of the pancreas. During recurring attacks of pancreatitis, tissues within pancreas may die and later become infected. This condition is called as acute necrotizing pancreatitis.
Case Presentation: A 48 yr old male visited in AVBRH with the chief complaints of pain in epigastric region, recurrent vomiting, and abdominal distention since 7 days. Otherwise client was alright. After undergoing investigations such as complete blood count, liver function test, kidney function test, CT Scan (Computed tomography) and sonography etc. He was diagnosed with Acute Necrotizing Pancreatitis and was admitted to male medi- cine ward No.29. He had past medical history of pain in epigastric region, fever, abdominal distention, since 5days. For these complaints his family members referred him in “Get Life Hospital” at Amravati. He was treated with antibiotics, analgesic, After CT scan, Sonography it was found that there was Acute pan- creatitis. That’s why his family members admitted him at A.V.B.R Hospital for further treatment.
Conclusion: These results support nonsurgical management, including early antibiotic treatment, in patients with sterile pancreatic necrosis. Patients respond well to treatment.