bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metaplectic representation and ordering (in)dependence in Vasiliev’s higher spin gravity
Authors: De Filippi David , Iazeolla Carlo , Sundell Per 
Published: July 2022

Abstract
We investigate the formulation of Vasiliev’s four-dimensional higher-spin gravity in operator form, without making reference to one specific ordering. More precisely, we make use of the one-to-one mapping between operators and symbols thereof for a family of ordering prescriptions that interpolate between and go beyond Weyl and normal orderings. This correspondence allows us to perturbatively integrate the Vasiliev system in operator form and in a variety of gauges. Expanding the master fields in inhomogenous symplectic group elements, and letting products be controlled only by the group, we specify a family of factorized gauges in which we are able to integrate the system to all orders, producing exact solutions, including but not restricted to ones presented previously in the literature; and then connect, at first order, to a family of rotated Vasiliev gauges in which the solutions can be represented in terms of Fronsdal fields. The gauge function responsible for the latter transformation is explicitly constructed at first order. The analysis of the system in various orderings is facilitated by an analytic continuation of Gaussian symbols, by means of which one can distinguish and connect the two branches of the metaplectic double cover and give a rationale to the properties of the inner Klein operators as Gaussian delta sequences defining analytic delta densities. As an application of some of the techniques here developed, we evaluate twistor space Wilson line observables on our exact solutions and show their independence from auxiliary constructs up to the few first subleading orders in perturbation theory.
Discrete integrable systems, supersymmetric quantum mechanics, and framed BPS states
Authors: Cirafici Michele , Del Zotto Michele 
Published: July 2022

AbstractIt is possible to understand whether a given BPS spectrum is generated by a relevant deformation of a 4D$$ \mathcal{N} $$N= 2 SCFT or of an asymptotically free theory from the periodicity properties of the corresponding quantum monodromy. With the aim of giving a better understanding of the above conjecture, in this paper we revisit the description of framed BPS states of four-dimensional relativistic quantum field theories with eight conserved supercharges in terms of supersymmetric quantum mechanics. We unveil aspects of the deep interrelationship in between the Seiberg-dualities of the latter, the discrete symmetries of the theory in the bulk, and quantum discrete integrable systems.
The PEE aspects of entanglement islands from bit threads
Authors: Lin Yi-Yu , Sun Jia-Rui , Sun Yuan , Jin Jie-Chen 
Published: July 2022

Abstract
We study the partial entanglement entropy (PEE) aspects of the holographic BCFT setup with an entanglement island, inspired by the holographic triality of the AdS/BCFT setup developed in the recent study on the black hole information problem, and the “PEE=CFF (component flow flux)” prescription, which is proposed recently to investigate the holographic PEE in the framework of bit thread formulation. Our study provides a bit thread description of the AdS/BCFT setup, which characterizes the specific entanglement details between the different parts of the system with an entanglement island, and may provide further insight into the black hole information problem. Furthermore, we show that in the context of island, one should distinguish between the fine-grained PEE and the semi-classical PEE. Interestingly, similar to the island rule of the fine-grained entropy in the semi-classical picture, we also propose the island rules of the fine-grained PEE.
Aspirin sensitivity of PIK3CA-mutated Colorectal Cancer: potential mechanisms revisited
Authors: Hall Daniella C. N. , Benndorf Ralf A. 
Published: July 2022

AbstractPIK3CAmutations are amongst the most prevalent somatic mutations in cancer and are associated with resistance to first-line treatment along with low survival rates in a variety of malignancies. There is evidence that patients carryingPIK3CAmutations may benefit from treatment with acetylsalicylic acid, commonly known as aspirin, particularly in the setting of colorectal cancer. In this regard, it has been clarified that Class IA Phosphatidylinositol 3-kinases (PI3K), whose catalytic subunit p110α is encoded by thePIK3CAgene, are involved in signal transduction that regulates cell cycle, cell growth, and metabolism and, if disturbed, induces carcinogenic effects. Although PI3K is associated with pro-inflammatory cyclooxygenase-2 (COX-2) expression and signaling, and COX-2 is among the best-studied targets of aspirin, the mechanisms behind this clinically relevant phenomenon are still unclear. Indeed, there is further evidence that the protective, anti-carcinogenic effect of aspirin in this setting may be mediated in a COX-independent manner. However, until now the understanding of aspirin’s prostaglandin-independent mode of action is poor. This review will provide an overview of the current literature on this topic and aims to analyze possible mechanisms and targets behind the aspirin sensitivity ofPIK3CA-mutated cancers.
Edge States for Generalized Iwatsuka Models: Magnetic Fields Having a Fast Transition Across a Curve
Authors: Giunti Arianna , Velázquez Juan J. L. 
Published: July 2022

AbstractIn this paper, we study the localization and propagation properties of the edge states associated with a class of magnetic Laplacians in$$\mathbb {R}^2$$R2. We assume that the intensity of the magnetic field has a fast transition along a regular and compact curve$$\Gamma $$Γ. Our main results extend to a general regular curve the study of the localized eigenfunction obtained when$$\Gamma $$Γis a straight line (i.e.Iwatsuka models). Furthermore, we include in our analysis the case of magnetic fields that slowly change along the curve$$\Gamma $$Γand we obtain a rigorous and explicit characterization of the asymptotic mass distribution of the edge state along$$\Gamma $$Γ.
Heat transfer at nanoscale and boundary conditions
Authors: Bochicchio I. , Giannetti F. , Sellitto A. 
Published: July 2022

AbstractA model of nonlocal heat transfer at nanoscale in rigid bodies is considered. Depending on the relevance of the particular interaction’s mechanism between the heat carriers and the lateral walls, three different strategies for the setting-up of the boundary conditions are analyzed, and the consequent forms of the basic fields have been obtained, as well. From the physical point of view, the possible influence of those interactions on the unknown fields is pointed out. From the mathematical point of view, instead, the well-posedness of the problem is shown.
Artificial intelligence and democratic legitimacy. The problem of publicity in public authority
Authors: Beckman Ludvig , Hultin Rosenberg Jonas , Jebari Karim 
Published: July 2022

AbstractMachine learning algorithms (ML) are increasingly used to support decision-making in the exercise of public authority. Here, we argue that an important consideration has been overlooked in previous discussions: whether the use of ML undermines the democratic legitimacy of public institutions. From the perspective of democratic legitimacy, it is not enough that ML contributes to efficiency and accuracy in the exercise of public authority, which has so far been the focus in the scholarly literature engaging with these developments. According to one influential theory, exercises of administrative and judicial authority are democratically legitimate if and only if administrative and judicial decisions serve the ends of the democratic law maker, are based on reasons that align with these ends and are accessible to the public. These requirements are not satisfied by decisions determined through ML since such decisions are determined by statistical operations that are opaque in several respects. However, not all ML-based decision support systems pose the same risk, and we argue that a considered judgment on the democratic legitimacy of ML in exercises of public authority need take the complexity of the issue into account. This paper outlines considerations that help guide the assessment of whether a ML undermines democratic legitimacy when used to support public decisions. We argue that two main considerations are pertinent to such normative assessment. The first is the extent to which ML is practiced as intended and the extent to which it replaces decisions that were previously accessible and based on reasons. The second is that uses of ML in exercises of public authority should be embedded in an institutional infrastructure that secures reason giving and accessibility.
Exploring the sources of knowledge diversity in founding teams and its impact on new firms’ innovation
Authors: Corrocher Nicoletta , Lenzi Camilla 
Published: July 2022

AbstractThis paper studies the relationship between founding team knowledge diversity and firms’ innovative performance. We posit that knowledge diversity entails two dimensions: a team dimension and an individual dimension. In particular, we argue that founding team knowledge diversity can derive both from the presence of founders with different knowledge backgrounds, and from the presence of similar jack-of-all-trades (JOTs). We suggest that knowledge diversity is positively associated with innovation, especially when diversity comes from founders with different knowledge backgrounds, instead of coming from many JOTs. Furthermore, it matters more for firms whose knowledge base is oriented towards technical and scientific applications, as opposed to firms with a generalist, business-oriented knowledge base. We provide support to these propositions relying on a study of 1,800 newly established firms in Europe.
Gender inequality and the entrepreneurial gender gap: Evidence from 97 countries (2006–2017)
Authors: Rietveld Cornelius A. , Patel Pankaj C. 
Published: July 2022

AbstractAlthough it seems almost a stylized fact that females are less likely than males to start new ventures, closing this gender gap is essential to foster sustainable economic growth. In this study, we analyze whether gender inequality, as measured at the country level by the World Economic Forum since 2006, is associated with the gender gap in entrepreneurship. By analyzing country-level information about gender inequality (97 countries) in combination with individual-level data from the Global Entrepreneurship Monitor (1,905,665 individuals) from the years 2006 to 2017, we find that in more gender equal countries involvement in total early-stage entrepreneurial activity (TEA) is higher. Gender inequality moderates the effect of gender on TEA, by almost closing the gender gap in entrepreneurship in the most gender equal countries. We show that gender inequalities in economic participation and opportunity as well as in political empowerment are the main drivers of this interaction effect. We find similar patterns when distinguishing between opportunity-driven and necessity-driven TEA. With opportunity-driven entrepreneurship as a potential vehicle for the economic empowerment of females, our study highlights the role of policies stimulating gender equality.
A first-in-human study of [68Ga]Ga-CDI: a positron emitting radiopharmaceutical for imaging tumour cell death
Authors: Ho Shon Ivan , Hennessy Thomas , Guille Jennifer , Gotsbacher Michael P. , Lay Angelina J. , McBride Bruce , Codd Rachel , Hogg Philip J. 
Published: July 2022

Abstract
Purpose
This study assesses human biodistribution, radiation dosimetry, safety and tumour uptake of cell death indicator labelled with 68Ga ([68Ga]Ga-CDI), a novel radiopharmaceutical that can image multiple forms of cell death.

Methods
Five participants with at least one extracranial site of solid malignancy > 2 cm and no active cancer treatment in the 8 weeks prior to the study were enrolled. Participants were administered 205 ± 4.1 MBq (range, 200–211 MBq) of [68Ga]Ga-CDI and 8 serial PET scans acquired: the first commencing immediately and the last 3 h later. Participants were monitored for clinical, laboratory and electrocardiographic side effects and adverse events. Urine and blood radioactivity was measured. Spherical volumes of interest were drawn over tumour, blood pool and organs to determine biodistribution and calculate dosimetry. In one participant, tumour specimens were analysed for cell death using terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) staining.

Results
[68Ga]Ga-CDI is safe and well-tolerated with no side effects or adverse events. [68Ga]Ga-CDI is renally excreted, demonstrates low levels of physiologic uptake in the other organs and has excellent imaging characteristics. The mean effective dose was 2.17E − 02 ± 4.61E − 03 mSv/MBq. It images constitutive tumour cell death and correlates with tumour cell death on histology.

Conclusion
[68Ga]Ga-CDI is a novel cell death imaging radiopharmaceutical that is safe, has low radiation dosimetry and excellent biodistribution and imaging characteristics. It has potential advantages over previously investigated radiopharmaceuticals for imaging of cell death and has progressed to a proof-of-concept trial.

Trial registration
ACTRN12621000641897 (28/5/2021, retrospectively registered)
Weighted U-statistics for likelihood-ratio ordering of bivariate data
Authors: Kulathinal Sangita , Dewan Isha 
Published: July 2022

AbstractCharacterisation of marginal distribution and density functions is of interest where data on a pair of random variables (X, Y) are observed. Stochastic orderings between (X, Y) have been studied in statistics and economics. Likelihood-ratio ordering is useful in understanding the behaviour of the random variables. In this article, tests based on U-statistics are proposed to test for equality of marginal density functions against the alternative of likelihood-ratio ordered when (X, Y) are dependent. The tests can be used when the data are either completely observed or subjected to independent univariate right censoring. The asymptotic variances of these tests are complicated and hence, are estimated using jackknife variance estimators. Validity of the jackknife variance estimators in statistical inference based on the proposed tests is demonstrated using simulation studies. The test for uncensored setting has desired size and good power for small sample. The performance of the tests for censored case depends on the sample size, proportion of censoring and the measure of dependence between X and Y. The tests are illustrated on three real data sets chosen in order to bring out various aspects of the tests.
Changes in freezing rain occurrence over eastern Canada using convection-permitting climate simulations
Authors: Marinier Sébastien , Thériault Julie M. , Ikeda Kyoko 
Published: July 2022

AbstractFreezing precipitation has major consequences for ground and air transportation, the health of citizens, and power networks. Previous studies using coarse resolution climate models have shown a northward migration of freezing rain in the future. Increased model resolution can better define local topography leading to improved representation of conditions that are favorable for freezing rain. The goal of this study is to examine the climatology and characteristics of future freezing rain events using very-high resolution climate simulations. Historical and pseudo-global warming simulations with a 4-km horizontal grid length were used and compared with available observations. Simulations revealed a northerly shift of freezing rain occurrence, and an increase in the winter. Freezing rain was still shown to occur in the Saint-Lawrence River Valley in a warmer climate, primarily due to stronger wind channeling. Up to 50% of the future freezing rain events also occurred in present day climate within 12 h of each other. In northern Maine, they are typically shorter than 6 h in current climate and longer than 6 h in warmer conditions due to the onset of precipitation during low-pressure systems occurrences. The occurrence of freezing rain also locally increases slightly north of Québec City in a warmer climate because of freezing rain that is produced by warm rain processes. Overall, the study shows that high-resolution regional climate simulations are needed to study freezing rain events in warmer climate conditions, because high horizontal resolutions better define small-scale topographic features and local physical mechanisms that have an influence on these events.
Surgical treatment of rectovaginal fistula—predictors of outcome and effects on quality of life
Authors: Söderqvist Erik V. , Cashin Peter H. , Graf Wilhelm 
Published: July 2022

Abstract
Purpose
To determine the results after rectovaginal fistula (RVF) repair and find predictors of outcome. Primary objective was fistula healing. Secondary outcomes were morbidity and patient health-related quality of life (HRQoL).

Method
An observational study of 55 women who underwent RVF repair including both local procedures and tissue transposition 2003–2018 was performed. Baseline patient and fistula characteristics were registered, combined with a prospective HRQoL follow-up and a general questionnaire describing fistula symptoms.

Results
Healing rate after index surgery was 25.5% (n = 14) but the final healing rate was 67.3% (n = 37). Comparing the etiologies, traumatic fistulas (iatrogenic and obstetric) had the highest healing rates after index surgery (n = 11, 45.9%) and after repeated operations at final follow-up (n = 22, 91.7%) compared with fistulas of inflammatory fistulas (Crohn’s disease, cryptoglandular infection, and anastomotic leakage) that had inferior healing rates after both index surgery (n = 7, 7.1%) and at final follow-up (n = 13, 46.4%). Fistulas of the category others (radiation damage and unknown etiology) included a small amount of patients with intermediate results at both index surgery (n = 1, 33.3%) and healing rate at last follow-up (n = 2, 66.7%). The differences were statistically significant for both index surgery (p = 0.004) and at final follow-up (p = 0.001). Unhealed patients scored lower than both healed patients and the normal population in 6/8 Rand-36 domains, but the differences were not statistically significant.

Conclusions
Most traumatic rectovaginal fistulas closed after repeated surgery whereas inflammatory fistulas had a poor prognosis. Low healing rates after local repairs suggest that tissue transfer might be indicated more early in the treatment process. Unhealed fistulas were associated with reduced quality of life.
Trial registration Clinicaltrials.gov No. NCT05006586.
Effect of national COVID-19 lockdown on the incidence of muscle, tendon and ligament injuries and related surgical procedures in the working-aged Finnish population
Authors: Möttönen Julius , Kuitunen Ilari , Uimonen Mikko , Mattila Ville M. , Paloneva Juha , Ponkilainen Ville 
Published: July 2022

Abstract
Introduction
The effect of lockdown on the incidence of fractures and severe injuries has been widely studied, whereas studies regarding muscle, tendon, and ligament injuries have not received as much attention. The aim of the study was to investigate the effect of the lockdown and later regional regulations due to the COVID pandemic on the incidence of muscle, tendon, and ligament injuries and related surgical procedures.

Materials and methods
This study focuses on the working-age population in the catchment areas of three major Finnish hospitals. Patients were divided into three age groups 18–34, 35–50 and 51–65 years of age. Suitable injuries were retrieved from the data using appropriate ICD-10 codes and procedure codes. The monthly incidence rate ratio (IRR), with 95% confidence intervals (CI), were compared between the year 2020 and the reference years 2017–2019.

Results
Upper and lower extremity injury ED visits decreased by 15.7 and 8.2%. For upper extremity injuries, a decrease in incidence was observed for all three age groups in March (IRR 0.52, CI 0.33–0.80), (IRR 0.53, CI 0.31–0.91), (IRR 0.60, CI 0.38–0.95), respectively. An increase in 18–34 years of age group was detected in June (IRR 1.49, CI 1.05–2.13). Lower extremity injuries decreased in 18–34 years of age group in March (IRR 0.62, CI 0.43–0.90) and April (IRR 0.60, CI 0.42–0.87).
A decrease on the incidence of surgeries was observed in April for the 35–50 (IRR 0.53, CI 0.29–0.97) and 51–65 years of age groups (IRR 0.58, CI 0.34–0.98).

Conclusions
The nationwide lockdown in spring 2020 led to a notable decrease in the incidence of emergency department visits and the surgical treatment of muscle, tendon, and ligament injuries in Finland.
New entity of microsecretory adenocarcinoma of salivary glands: first case with recurrence and metastases — proof of malignancy
Authors: Jurmeister Philipp , Haas Christian , Eisterer Wolfgang , Rogatsch Hermann , Ihrler Stephan 
Published: July 2022

Abstract
Microsecretory adenocarcinoma (MSA) of the salivary glands is a recently described entity. Due to lack of reported metastases, in 30 cases described until now, the designation as low-grade cancer was so far solely based on demonstration of local tumor invasion and in a single case with perineural invasion. We herein describe the first documented case with local recurrence and hematogenous metastases.
Predicting time to treatment in follicular lymphoma on watchful waiting using baseline metabolic tumour burden
Authors: Leccisotti Lucia , Maccora Daria , Malafronte Rosalia , D’Alò Francesco , Maiolo Elena , Annunziata Salvatore , Rufini Vittoria , Giordano Alessandro , Hohaus Stefan 
Published: July 2022

Abstract
Purpose
Asymptomatic patients with follicular lymphoma (FL) and a low tumour burden can be followed without initial therapy, a strategy called watchful waiting (WW). Prediction of the time to treatment (TTT) is still a challenge. We investigated the prognostic value of baseline total metabolic tumour volume (TMTV) and whole-body total lesion glycolysis (WB-TLG) to predict TTT in patients with FL on WW.

Methods
We conducted a retrospective study of 54 patients with FL (grade 1–3a) diagnosed between June 2013 and December 2019, staged with FDG PET/CT, and managed on WW. Median age was 62 years (range 34–85), stage was advanced (III–IV) in 57%, and FLIPI score was intermediate to high (≥ 2) in 52% of the patients.

Results
The median TMTV and WB-TLG were 7.1 and 43.3, respectively. With a median follow-up of 59 months, 41% of patients started immuno-chemotherapy. The optimal cut-points to identify patients with TTT within 24 months were 14 for TMTV (AUC 0.70; 95% CI 51–88) and 64 for WB-TLG (AUC 0.71; 95% CI 52–89) (p < 0.005). The probability of not having started treatment within 24 months was 87% for TMTV < 14 and 53% for TMTV ≥ 14 (p < 0.005). TMTV was independent of the FLIPI score for TTT prediction. Patients with both FLIPI ≥ 2 and TMTV ≥ 14 had only an 18% probability of not having started treatment at 36 months, while this probability was 75% in patients with TMTV < 14.

Conclusion
Metabolic tumour volume parameters may add information to clinical scores to better predict TTT and better stratify patients for interventional studies.