bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contactless Tracking of Decomposition in Self‐Reporting Ceramic Cr‐Al‐B Coatings
Authors: Pöllmann Peter J. , Lellig Sebastian , Bogdanovski Dimitri , Navidi Kashani Amir Hossein , Holzapfel Damian M. , Azina Clio , Schweizer Peter , Hans Marcus , Zöll Paula , Primetzhofer Daniel , Kolozsvári Szilárd , Polcik Peter , Michler Johann , Schneider Jochen M. 
Published: February 2025

AbstractAutonomous health tracking of coated components via electrical resistance measurements requires physical connections between coating and readout. Here, the proof of concept for contactless tracking of decomposition in autonomous self‐reporting Cr‐Al‐B coatings is demonstrated. Contactless‐monitored electrical resistance changes of Cr0.34Al0.31B0.35 coatings reveal decomposition of Cr2AlB2 and Cr3AlB4 to CrB and CrB2. Comparison of contactless‐measured resistance data with in situ and ex situ high‐resolution scanning transmission electron microscopy, as well as ex situ X‐ray diffraction and elastic‐recoil detection analysis, reveals the untapped potential of assessing materials health data in extreme environments. More sustainable materials consumption is enabled by continuous or periodic contactless tracking of materials health data as the individual remaining component lifetime is utilized instead of the much shorter lifetime prediction resulting from safety‐factor‐based design approaches.
Reconfigurable Logic Gate Enabled by Dual‐Gating of Silicon Nanomembrane Field‐Effect Transistors
Authors: Hwang Joonha , Kwon Jong Ik , Choi Moon Kee , Lim Jung Ah , Kim Sangsig , Choi Changsoon 
Published: February 2025

AbstractConventional processors often underutilize their computational resources because of the fixed functionality of logic gates; numerous logic gates should be embedded to support all necessary operations, even if many of them are rarely used. Reconfigurable logic gates (RLGs) offer a promising solution as they dynamically switch their logical functionality according to the demands of specific operations. Here, a novel RLG architecture based on the dual‐gate silicon nanomembrane (SiNM) field‐effect transistors (FETs) is proposed. By reconfiguring the electrostatic doping profiles of the SiNM channel, the dual‐gate SiNM FET can operate as three distinct electronic components; a forward‐biased diode, a backward‐biased diode, and a variable resistor. Furthermore, the three dual‐gate SiNM FETs are integrated to implement a single RLG, whose Boolean logic functions can be reconfigured between AND and OR operations. In addition, an array of three RLGs can be used to perform 32‐bit masking operations, thereby validating their effectiveness in digital data processing.
SIRT3‐Mediated Deacetylation of DRP1K711 Prevents Mitochondrial Dysfunction in Parkinson's Disease
Authors: Xi Ye , Tao Kai , Wen Xiaomin , Feng Dayun , Mai Zifan , Ding Hui , Mao Honghui , Wang Mingming , Yang Qian , Xiang Jie , Zhang Jie , Wu Shengxi 
Published: February 2025

AbstractDysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD). Aberrant mitochondrial fission induced by dynamin‐related protein 1 (DRP1) causes mitochondrial dysfunction in dopaminergic (DA) neurons. However, the mechanism of DRP1 activation and its role in PD progression remain unclear. In this study, Mass spectrometry analysis is performed and identified a significant increased DRP1 acetylation at lysine residue 711 (K711) in the mitochondria under oxidative stress. Enhanced DRP1K711 acetylation facilitated DRP1 oligomerization, thereby exacerbating mitochondrial fragmentation and compromising the mitochondrial function. DRP1K711 acetylation also affects mitochondrial DRP1 recruitment and fission independent of canonical S616 phosphorylation. Further analysis reveals the critical role of sirtuin (SIRT)‐3 in deacetylating DRP1K711, thereby regulating mitochondrial dynamics and function. SIRT3 agonists significantly inhibit DRP1K711 acetylation, rescue DA neuronal loss, and improve motor function in a PD mouse model. Conversely, selective knockout of SIRT3 in DA neurons exacerbates DRP1K711 acetylation, leading to increased DA neuronal damage, neuronal death, and worsened motor dysfunction. Notably, this study identifies a novel mechanism involving aberrant SIRT3‐mediated DRP1 acetylation at K711 as a key driver of mitochondrial dysfunction and DA neuronal death in PD, revealing a potential target for PD treatment.
Immunostimulatory Hydrogel with Synergistic Blockage of Glutamine Metabolism and Chemodynamic Therapy for Postoperative Management of Glioblastoma
Authors: Guo Yiran , Jiang Tianhe , Liang Sen , Wang Anhe , Li Jieling , Jia Yi , Li Qi , Yin Jian , Bai Shuo , Li Junbai 
Published: February 2025

AbstractGlioblastoma multiforme (GBM) is one of the most lethal malignant brain tumors in the central nervous system. Patients face many challenges after surgery, including tumor recurrence, intracranial pressure increase due to cavitation, and limitations associated with immediate postoperative oral chemotherapy. Here an injected peptide gel with in situ immunostimulatory functions is developed to coordinate the regulation of glutamine metabolism and chemodynamic therapy for overcoming these postoperative obstacles. The methodology entails crafting injectable gel scaffolds with short peptide molecules, incorporating the glutaminase inhibitor CB‐839 and copper peptide self‐assembled particles (Cu‐His NPs) renowned for their chemodynamic therapy (CDT) efficacy. By fine‐tuning glutamic acid production via metabolic pathways, this system not only heightens the therapeutic prowess of copper peptide particles in CDT but also escalates intracellular oxidative stress. This dual mechanism culminates in augmented immunogenic cell death within glioblastoma multiforme cells and improves a conducive immune microenvironment. Based on the concept of metabolic reprogramming, this treatment strategy has great potential to significantly reduce GBM tumor recurrence and prolong median survival in murine models.
Using Large Language Model to Optimize Protein Purification: Insights from Protein Structure Literature Associated with Protein Data Bank
Authors: Chen Zhuojian , Sivaraman J. 
Published: February 2025

AbstractObtaining pure and homogeneous protein samples is vital for protein biology studies, yet optimizing protein expression and purification methods can be time‐consuming because of variations in factors like expression conditions, buffer components, and fusion tags. With over 81 000 Protein Data Bank (PDB)‐associated articles as of October 2024, manual extraction of relevant methods is impractical. To streamline this process, an automated tool is developed by incorporating a large language model (LLM) to extract and classify key data from these articles. The information extraction accuracy is enhanced by a 2‐step‐LLM and a 3‐step‐prompt. The key findings include: 1) Tris buffer is used in 49.2% of cases, followed by 4‐(2‐hydroxyethyl)‐1‐piperazineethanesulfonic acid (HEPES) and phosphate buffers. 2) Polyhistidine tags dominate at 82.5%, followed by glutathione S‐transferase (GST) and maltose‐binding protein (MBP) tags. 3) E. coli expression is done at 16–20 °C, with induction period favoring 12–16 h (69.0%) over 3–6 h (14.3%). The statistical analyses highlight the correlation between protein properties and purification strategies. This tool is validated through two case studies: method bias for membrane protein purification, and crosslinker/detergent preferences for Cryo‐Electron Microscopy sample preparation. These findings provide a valuable resource for designing protein expression and purification experiments.
Color Biases and Preferences in Zoo‐Housed Chimpanzees (Pan troglodytes), Gorillas (Gorilla gorilla gorilla), and Japanese Macaques (Macaca fuscata)
Authors: Leinwand Jesse G. , Joshi Priyanka , Vale Gillian 
Published: February 2025

ABSTRACTColors are an important signal for many primate species and have the potential to influence behavior and cognition. Primates may consciously or unconsciously prioritize their attention toward certain color stimuli to quickly identify consequential events, conspecifics, or resources. On the other hand, primates' color preferences can be modulated by memory, experiences, and affective responses. Few studies have explored the multifaceted nature of attention to colors in primate species that vary in their socioecologies and phenotypes, both of which may influence their responses to specific colors. The colors that rapidly capture primates' attention, and those they prefer, thus remain poorly understood. In a series of touchscreen experiments, we investigated responses to 9 perceptually distinct colored squares by 7 chimpanzees (Pan troglodytes), 11 gorillas (Gorilla gorilla gorilla), and 10 Japanese macaques (Macaca fuscata). We controlled for contextual cues known to influence color responses and assessed attentional biases using a dot probe task (Experiment 1) and preferences using a two‐item forced‐choice task (Experiments 2 and 3). In Experiment 1, we found that chimpanzees and gorillas showed the strongest attentional bias toward black, whereas the Japanese macaques showed the strongest bias toward red. These attentional biases suggest a potential relationship between species coloration and their attention to colors. In Experiments 2 and 3, all three species preferentially selected red, with Japanese macaques showing the strongest preference, supporting earlier findings that highlighted red as a particularly salient color to primates. Future research is needed to investigate the role of prior experience on primates' responses to colors.
Recovery of Silver From Wastewater by Polydopamine Functionalized Polystyrene Mesoporous Microspheres and Its Secondary Catalytic Application in Dye Removal
Authors: Gong Han , Liu Xiangchi , Liu Baijun , Zhang Mingyao 
Published: February 2025

ABSTRACTHeavy metal and dye pollution are significant environmental challenges that seriously threaten human health and ecosystem balance. This study introduces a new method for recovering Ag+ from wastewater and uses the recovered silver for secondary catalytic applications in dye degradation. Polydopamine functionalized polystyrene mesoporous microspheres (PPS‐PDA) were prepared using a green mussel chemical method based on monodisperse polystyrene mesoporous microspheres (PPS) with a diameter of approximately 7 μm. According to the results of Brunauer Emmett Teller Analyzer, the average pore size of PPS‐PDA is 17.88 nm, the porosity is 0.53%, and the specific surface area is 54.52 m2/g. By observing the scanning electron microscope and energy dispersive spectroscopy, PPS‐PDA has an adsorption effect on Ag+ in silver ammonia solution and can adsorb up to 40% of silver ammonia solution. The catalytic process was monitored by UV–visible light. The adsorbed Ag‐supported polydopamine functionalized polystyrene mesoporous microspheres (PPS‐PDA‐Ag) showed strong catalytic activity in the process of methylene blue reduction, and the catalytic behavior was consistent with the pseudo‐second‐order kinetic model. The catalyst maintained an efficiency of 85% in 10 cycles, highlighting its potential in sustainable wastewater treatment.
The morphology of the oval window in Paranthropus robustus compared to humans and other modern primates
Authors: Fernandez Ruy , Braga José 
Published: February 2025

AbstractThe oval window (OW) is an opening connecting the inner and middle ear. Its area has been shown to consistently scale with body mass (BM) in primates, and has been used alongside semi‐circular canal (SCC) size to differentiate Homo sapiens and fossil hominins, including Paranthropus robustus. However, while the morphology of other inner ear elements, such as cochlea and SCCs, has been extensively studied in primates, OW shape has received little attention. In this study, we assess OW morphological variability in extant primates, and compare P. robustus to extant hominids. The potential of OW size to predict BM is also assessed. For this, measurements were performed on 3D scans from extant primate species and of P. robustus from the sites of Kromdraai, Swartkrans, and Drimolen. Size was assessed using perimeter (OWP), area (OWA), and centroid size (OWCS). Shape was assessed using geometric morphometric methods. The OW has no sexual dimorphism; there is no size difference between juveniles and adults, but there is a slight shape difference between human juveniles and adults, with a seemingly opposite ontogenetic trajectory compared to other primates. P. robustus has an intermediary OW shape between apes and humans, with more ape‐like specimens from Kromdraai and more human‐like ones from Drimolen. Overall, OW morphology discriminates primate species well enough, especially H. sapiens. BM is well explained by OWA, but OWA is not reliable as a BM proxy due to high prediction errors. Nonetheless, the OWA of P. robustus suggests a BM close to that of a chimpanzee.
Maternal Diarrhea During the Periconceptional Period and the Risk of Birth Defects, National Birth Defects Prevention Study, 2006–2011
Authors: Waller Dorothy Kim , Mohan Dass Nithya Lakshmi , Oluwafemi Omobola O. , Agopian A. J. , Tark Ji Yun , Hoyt Adrienne T. , Scheuerle Angela E. , Canfield Mark A. ,   the National Birth Defects Prevention Study
Published: February 2025

ABSTRACTBackgroundThe primary objective of this study was to assess associations between maternal reports of diarrhea during early pregnancy and a range of different birth defects, most of which have not been assessed in previous studies. The secondary objective was to determine whether associations were modified by maternal use of multivitamins.MethodsWe analyzed data on 16,675 mothers who participated in the National Birth Defects Prevention Study (NBDPS) and delivered between 2006 and 2011. Logistic regression was used to evaluate associations between maternal report of diarrhea during the periconceptional period and 32 categories of birth defects. Odds ratios were adjusted for nine covariates.ResultsEleven percent of women reported having diarrhea during the periconceptional period. We observed elevated associations (p < 0.10) between maternal report of diarrhea lasting 1–5 days and 9 of 32 independent categories of birth defects (hypoplastic left heart, muscular ventricular septal defect, single ventricle complex, secundum atrial septal defect, esophageal atresia, diaphragmatic hernia, omphalocele, gastroschisis, and amniotic band syndrome). The elevated adjusted odds ratios (aORs) ranged from 1.45 to 2.62. There were no decreased associations between maternal report of diarrhea lasting 1–5 days and any of the 32 birth defects. There was no evidence for a significant linear trend of stronger associations between maternal diarrhea and birth defects among mothers who had inadequate or suboptimal use of multivitamins.ConclusionOur results are consistent with modest associations between shorter, but not longer, bouts of maternal diarrhea and specific categories of birth defects. These results add to existing evidence, suggesting maternal diarrhea and gastrointestinal infections during early pregnancy are associated with a higher frequency of some birth defects.
Employee Organisational Commitment and Corporate Environmental Sustainability Practices: Mediating Role of Organisation Innovation Culture
Authors: Bhuiyan Faruk , Adu Douglas A. , Ullah Hafij , Islam Nurul 
Published: February 2025

ABSTRACTThe growing concerns about climate change have seen global leaders and the international community launch diverse initiatives, deals and reforms in an attempt to combat its negative impact. In response to these initiatives, corporates are increasingly prioritising environmental sustainability practices, such as reducing resource use, recycling and redesigning products and services to transition to sustainable operations, as a means of promoting trust and credibility, increasing their reputation and protecting the planet. However, the extant literature does not provide a clear understanding of the determinants of promoting corporate environmental sustainability practices (CESPs). Thus, drawing upon both resource‐based views (RBVs) of the firm and the economic views of neo‐institutional theory (NIT), this study examined the role of employee organisational commitment (EOC) and organisation innovation culture (IC) in promoting CESP. This quantitative study collected the required data through a questionnaire survey of senior to mid‐level managers of a total of 201 Dhaka Stock Exchange (DSE)‐listed and non‐listed firms. A two‐step structural equation modelling (SEM) technique, employing SmartPLS, was followed to test the study's hypothesised associations. The findings provide evidence of a direct association between EOC and CESP and an indirect association through IC. Our findings are robust as alternative models were developed and tested based on different control and instrumental variables relating to organisational characteristics. The findings of the study contribute to the environmental sustainability literature by providing empirical evidence of the importance of EOC and IC in promoting CESP. Further, the findings inform managers, governments, foreign investors and other stakeholders on the importance of building EOC and developing suitable cultural practices within an organisation that promote CESP.
ReaxFF MD investigation of different JP8 surrogates on combustion mechanism and reaction kinetics
Authors: Liu Yang , Sun Hui , Wang Lu , Gao Qing Yun 
Published: February 2025

AbstractThis work aims to investigate the combustion characteristics difference between JP8‐1 and JP8‐2, and to reveal the combustion mechanism of JP8 surrogate fuels by reactive molecular dynamic simulations (ReaxFF). The JP8‐1 fuel shows higher reaction activity, and the JP8‐2 surrogate conversion is faster than that of the JP8‐1 model. The maximal mass fraction difference for two surrogate fuels consumption can be up to 12% in the pyrolysis process. The differences of reaction pathways, oxygen‐containing intermediates, and key products between two surrogate fuels have been analyzed using the VARxMD software. The evolution trends of the vital products and key intermediates of the two fuels are similar owing to the similar fuel structures of linear paraffin components. The branched component isooctane in JP8‐1 model can enhance the formation of cyclic chain hydrocarbons products, while branched paraffin component decalin in JP8‐2 model promote the formation of structurally stable cycloalkanes. Compared to JP8‐2 fuel, the formation of CH2O and coke precursors, the JP8‐1 fuel generate more harmful substances. This work can provide an important theoretical basis for the rational design and screening of high‐performance surrogate components and additives for complex multi‐component jet fuels. And also suggests that the ReaxFF simulation method have the potential as an effective approach for evaluating combustion behaviour in fuel combustion.
An Effective Reaction‐based Virtual Screening Method to Discover new CDK8 Ligands
Authors: Chen Wei , Fang Hanlin , He Huan , Ping Jing , Ge Jianxin 
Published: February 2025

Cyclin Dependent Kinase 8 (CDK8) is a valuable drug target for cancer suppression. Through an effective reaction‐based virtual screening method consisting of pharmacophore modeling, Scifinder database searches, and energy evaluations, a number of new type II CDK8 ligands were discovered with comparable or better binding free energies than the ones reported in literature. In this method, a pharmacophore model, derived from seven crystal structures of CDK8 and type II ligands, was able to catch the key interactions for ligands binding at the ATP binding site of CDK8. This model then was used to screen the results from Scifinder database searches that apply chemical reaction rules in the search cycles, and the output compounds were evaluated and ranked first by a fast energy estimation method and then by the VM2 free energy calculation method. Among the top discovered ligands, three have lower Kd values against CDK8 than a potent reference ligand, and compound F (3‐[3‐tert‐butyl‐1‐(4‐methylphenyl)‐1H‐pyrazol‐5‐yl]‐1‐(8‐hydroxynaphthalen‐1‐yl)urea) is the most potent one with an Kd value of 7.5 nM. Compound F deserves to be a promising lead compound for further development. This effective virtual screening method and the novel compounds found in this work have implication for CDK8 drug discovery.
A Novel Y‐Sepic High Boost DC‐DC Converter for Renewable Energy Applications
Authors: Li Haibin , Chen Yin , Jin Tao 
Published: February 2025

ABSTRACTThis paper proposes a novel Y‐Sepic high boost DC‐DC converter, which is characterized by high voltage gain, continuous input current, low voltage stress of the switch and diodes, and high efficiency. The proposed converter is obtained by hybridizing the Y‐source and Sepic converters. With the coupled inductor turns ratio introduced in the converter, the circuit can operate in an appropriate duty cycle D while maintaining high voltage gain. The working states of the proposed converter are discussed. Then, the voltage and current stresses of components are deduced. The device design considerations have been presented. The power losses and efficiency are calculated. The derivation of the real voltage gain and the voltage gain in DCM have been performed. Besides, a small signal analysis and comparisons with other topologies have been conducted. Finally, a prototype made in the laboratory verifies the effectiveness of the proposed converter. The efficiency is 94.6% when the output power reaches 300 W.
Loss of the epithelial transcription factor grhl3 leads to variably penetrant developmental phenotypes in zebrafish
Authors: Mathiyalagan Nishanthi , Johnson Travis K. , Di Pastena Zachary , Fuller Jarrad N. , Miles Lee B. , Dworkin Sebastian 
Published: February 2025

AbstractBackgroundEnvironmental influence is critical for embryogenesis but is significantly under‐appreciated under lab conditions, which are not typically designed to robustly test environmental variability. Here, we report environmental effects on the developmental phenotype of zebrafish lacking the transcription factor Grainyhead‐like 3 (grhl3), a highly conserved gene that is pivotal in epithelial barrier formation, neurulation, craniofacial development, and convergence‐extension.ResultsWe had previously reported that deletion of grhl3 led to embryonic lethality by 11 h post‐fertilization (hpf); however, housing these grhl3‐lines in a different aquatic facility led to substantial differences in phenotypic presentation in grhl3‐nullizygous (grhl3−/−) embryos. We found that grhl3−/− embryos presented with three distinct phenotypes, characterized by significant reductions in body length, aberrant orofacial cavity formation and craniofacial morphogenesis and impaired intestinal barrier maintenance.ConclusionsOur study describes a new model of partial phenotypic penetrance in genetically identical embryos. This may serve as a valuable model system in which to understand gene–environment interactions in developmental and epithelial homeostasis.