bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN SISTEM MANAJEMEN KESELAMATAN DAN KESEHATAN KERJA (SMK3) UNTUK MEMINIMALKAN KECELAKAAN KERJA DENGAN METODE FAULT TREE ANALYSIS DI PT. SUMBER SUKSES GANDA
Authors: Arifin Zaenal 
Published: December 2022

ABSTRAKPenerapan Sistem Manajemen Keselamatan dan Kesehatan Kerja (SMK3) Untuk Meminimalkan Kecelakaan Kerja Dengan Metode FTA. Program Sarjana. Program Studi Teknik Industri. Universitas Riau Kepulauan.PT. Sumber Sukses Ganda dalam produktivitasnya tidak terlepas dari masalah yang dihadapi misalnya adanya kecelakaan kerja, penyakit akibat kerja dan akibat negatif industri terhadap lingkungan sekitarnya, jadi tingkat keselamatan kerja manusia sebagai faktor produksi sangat penting agar produktivitas yang optimal dapat dicapai.Judul dari penelitian ini adalah “Penerapan Sistem Manajemen Keselamatan dan Kesehatan Kerja (SMK3) untuk Meminimalkan Kecelakaan Kerja Dengan Metode Fault Tree Analysis pada PT. Sumber Sukses Ganda”. Tujuan dari penelitian ini ialah untuk menganalisis sejauh mana penerapan Program Kesehatan dan Keselamatan Kerja di PT. Sumber Sukses Ganda dan untuk mengetahui faktor-faktor apa saja yang mempengaruhi penerapan Program Keselamatan dan Kesehatan Kerja di PT. Sumber Sukses Ganda. Metode yang digunakan pada penelitian ini yaitu metode kualitatif, dimana pengumpulan data dilakukan dengan cara membagikan kuesioner kepada karyawan PT. Sumber Sukses Ganda. Objek penelitian ini adalah karyawan yang sudah bekerja lebih dari 1 tahun. Hasil dari pada penelitian ini merupakan Penerapan Program Kesehatan dan Keselamatan Kerja di PT. Sumber Sukses Ganda belum terlakasana dengan maksimal, dikarenakan ada faktor yang mempengaruhi Penerapan Program Keselamatan dan Kesehatan Kerja pada PT. Sumber Sukses Ganda, yaitu penggunaan APD, penggunaan rambu-rambu K3, SDM, dan Teknologi. Kata Kunci: Penerapam SMK3, Resiko Kecelakaan Kerja, Fault Tree Analysis
PENERAPAN PRINSIP ANTHROPOMETRI DAN QFD UNTUK REDESAIN ALAT BANTU PENGAIT TONG ASPAL
Authors: Putera Dimas Akmarul , Oktavia Puspita Rini Rosie , Mulyadi Tirta , Dermawan Aulia Agung , Ilham Wahyudi 
Published: December 2022

PT. XYZ merupakan perusahaan yang bergerak di bidang produksi aspal panas (hotmix). Proses produksi pada perusahaan yaitu pengenceran tar, penuangan material, pengeringan material dan pencampuran material kemudian dipindahkan ke dalam truk pengantar. Alat pengait digunakan untuk memindahkan tong aspal pada stasiun pengenceran tar yang dimana tong yang berisi tar yang dipindahkan memiliki berat 15 kilogram dan bersuhu 200ᵒC. Alat pengait aktual memiliki dimensi panjang 80 cm dan tidak memiliki pegangan. Hasil pengamatan visual secara langsung menunjukkan bahwa alat pengait ternyata tidak memiliki dimensi yang sesuai dengan data antropometri operator dan operator merasakan panas. Tujuan penelitian ini adalah mendapatkan desain alat pengait ergonomis berdasarkan antropometri operator dan menilai karakteristik teknik alat pengait tong aspal dengan menggunakan QFD. Kemudian untuk mengolah data berikutnya adalah menyebarkan data kebutuhan operator menggunakan kuesioner terbuka dan tertutup, kemudian diuji kenormalan data antropometri operator dengan SPSS 19. Hasil dari penelitian ini adalah dimensi alat pengait sepanjang 100 cm, memiliki pegangan yaitu dengan busa setebal 3,3 cm menggunakan dimensi Diameter Genggaman Tangan (DGT).
PERANCANGAN MUSEUM B.J. HABIBIE DENGAN PENDEKATAN GREEN ARCHITECTURE SEBAGAI WISATA EDUKASI DI KOTA BATAM
Authors: Farell Evan , Ngurah Anom Gunawan I Gusti 
Published: December 2022

Kota Batam merupakan salah satu kota yang terletak di Kepulauan Riau dan bertetangga dengan Singapura. Tidak terpungkiri bahwa banyak wisatawan yang keluar masuk ke Kota Batam, Kota Batam sendiri di bawah olahannya Otorita Batam yang pernah di pimpin oleh B.J. Habibie. Sosok B.J. Habibie pun sangat berkontribusi besar pada kota ini, beliau sudah merencankan bahwa suatu saat Singapura akan penuh dan para investor akan masuk ke Kota Batam. Namun Kota Batam sendiri masih sangat kurang dalam objek wisata di kota ini. Dari permasalahan tersebut diakukan penelitian secara cross-sectional dan kualitatif dengan survey langsung serta pengenalan dekat dengan site. Dengan dilakukan penelitian ini diharapkan dapat menghasilkan desain museum sebagai wisata edukasi yang inovatif, sustain, berkonsep Green Architecture dan layak sebagai Ikon Kota Batam. Serta perancangan ini menjadi suatu bentuk penghormatan bagi almrh B.J. Habibie atas jasanya di Kota Batam. Kata kunci : Museum; Wisata Edukasi; Green Architecture
Drugs territorialization in the era of PNRR: perspectives, opportunities and considerations from a panel of experts
Authors: Marata Anna Maria , Marrocco Walter , Arcangeli Emanuela , Battistini Mattia , Buzzetti Giuliano , Candido Riccardo , Casadei Gianluigi , Cattel Francesco , Cavaliere Arturo , Consoli Agostino , Corrao Giovanni , Didoni Guido , Di Gesù Mauro , Giovanzana Alberto , Lenzi Matteo , Medaglia Massimo , Meloncelli Marta , Palcic Stefano , Pani Marcello , Patarnello Francesca , Pria Emanuele , Scaduto Dario , Tozzi Valeria , Zibellini Marco , Crovato Elisa 
Published: December 2022

This document illustrates the results of the work of two interdisciplinary and multistakeholder panels (researchers, public institutions, and industry representatives) on drug territorialization and digitalization, organized as part of a residential seminar held on 30 September and 1st October 2021. Arising from some considerations about the demand for health and the provisions of the National Recovery and Resilience Plan (PNRR), the discussion touched various aspects of managing the transition from current to future management models. The importance of identifying criteria for prioritizing interventions in the area emerged: different methods of drug delivery, scientific information and measurement, re-evaluation of pathologies that can be managed in this area. Finally, the role of digitization within this change was explored. The opinions provided by the experts move towards making the most of the opportunities arising from PNRR, in terms of investments in healthcare and data application, with a view to improve health system efficiency, patient care and related outcomes.
BEYİN YAŞLANMASINDA MOLEKÜLER MEKANİZMALAR
Authors: ÖZDEK Esra , HAN Sevtap 
Published: December 2022

Amaç: Bu derlemede beyinde yaşlanmayla birlikte oluşan moleküler değişimlerin anlatılması amaçlanmıştır. Beyin yaşlanmasının moleküler mekanizmaları; oksidatif stres, mitokondriyal disfonksiyon, endoplazmik retikulum stres, otofaji, inflamasyon, lizozom ve proteazom işlevinin bozulması, bozulmuş DNA onarımı başlıkları altında toplanmış ve bu konulara odaklanılmıştır.
Sonuç ve Tartışma: Yaşlanma, muhtemelen organizmalardaki hasar birikiminden ve/veya bakım ve onarım mekanizmalarındaki düşüşten kaynaklanan çok faktörlü bir süreçtir. Yaşlanmayla birlikte beyinde de yapısal ve fonksiyonel birçok değişim meydana gelmektedir. Bu değişiklikler nörodejeneratif bozukluklarla birlikte Alzheimer, Parkinson gibi hastalıklara yatkınlık oluşturmaktadır. Beyin yaşlandığında öğrenme, karar verme, hafıza gibi yeteneklerinde azalmalar görülmektedir. Beyin yaşlanmasına bağlı hastalıklara ve fonksiyonel bozukluklara karşı terapötik veya koruyucu yaklaşımlar geliştirmek için beyin yaşlanmasının moleküler düzeydeki mekanizmalarının aydınlatılmasına ihtiyaç vardır.
REBOKSETİN’İN DİYABETİK SIÇANLARDA BOZULMUŞ DAVRANIŞ PARAMETRELERİ ÜZERİNDEKİ YARARLI ETKİLERİ
Authors: TURAN YÜCEL Nazlı , KANDEMİR Ümmühan , ÜÇEL Umut İrfan , CAN Özgür Devrim , DEMİR ÖZKAY Ümide 
Published: December 2022

Amaç: Diyabetik hastalarda duygu-durum hastalıklarının ve kognitif bozukluk insidansının genel popülasyona oranla daha yüksek olduğu bilinmektedir. Bu çalışmada, klinikte antidepresan etkinliği için reçete edilen reboksetin’in sıçanlarda diyabet ile indüklenen davranışsal ve bilişsel değişiklikler üzerine etkinliğinin araştırılması amaçlanmıştır.
Gereç ve Yöntem: Sıçanlarda deneysel diyabet modeli 50 mg/kg tek doz streptozotosin enjeksiyonu (i.v.) ile oluşturulnuştur. Reboksetin tedavisine diyabetik komplikasyonların oluşması için 4 hafta beklendikten sonra başlanmıştır. Deney hayvanlarının depresyon ve anksiyete düzeyleri sırasıyla modifiye zorlu yüzme ve yükseltilmiş artı şekilli labirent testleri ile araştırılmış; kognitif performansları ise Morris su tankı ve pasif sakınma testleri ie değerlendirilmiştir. Hayvanlarının motor aktiviteleri de aktivite kafesi ve Rota-rod testleri ile incelenmiştir.
Sonuç ve Tartışma: Deneyler sonucunda, diyabetik sıçanların depresyon ve anksiyete düzeylerinin yükseldiği ve bilişsel performanslarının zayıfladığı belirlenmiştir. İki hafta süre ile uygulanan reboksetin tedavisi (8 ve 16 mg/kg) diyabetik sıçanların yüksek depresyon ve anksiyete düzeylerini azaltırken, zayıflamış olan bilişsel performanslarını kayda değer ölçüde güçlendirmiştir. Elde edilen bulgular reboksetin’in diyabete bağlı olarak ortaya çıkan davranışsal ve bilişsel bozuklukların tedavisinde terapötik bir potansiyele sahip olabileceğine işaret etmiştir.
Penerapan Model Pembelajaran Kontekstual Berbantukan Media Pop-Up Book untuk Meningkatkan Pemahaman Konsep IPA Siswa Sekolah Dasar
Authors: Marlina Diyan 
Published: December 2022

The purpose of this research is to improve the understandaing of the concept of science learning of grade sixth students of SDN Jabung 2 Panekan Magetan by implementing contextual learning model with the help of pop-up book media. The approach used in this study is a qualitative approach and this type of research is a classroom action research (CAR). The subjects of the research in this study were students of class VI SDN Jabung 2 Panekan Magetan with amounted to 18 students. The data collection in this research is the learning implementation plan (RPP), student activity observation sheet, teacher activity observation sheet, student worksheet, test, anda interview. The results showed that the percentage of cycle 1 test results was 66,67% and the percentage of cycle 2 test result was 88,89%. So that the contextual learning model with the pop-up book media on the earth and space theory can improve student concept understanding of science learning from cycle 1 to cycle 2 that is 22,22%.
Pengaruh Penerapan Model Pembelajaran Tipe Team Games Turnamen (TGT) Berbantuan Permainan QUACI Sebagai Media Pembelajaran pada Materi “Pasar” Terhadap Hasil Belajar
Authors: Kiswanti Hanny Mahasih , Purwati Titik 
Published: December 2022

The purpose of this study was to determine the effect of the application of the TGT (Team Games Tournament) type of cooperative learning model assisted by the QUACI (Quartet Card Innovation) as a learning medium on market material on the learning outcomes of Grade VIII students of Middle School, Kertanegara Malang. This research uses a quantitative approach with an experimental research method. Research with experimental methods is intended to investigate the possibility of a causal relationship (Cause and Effect Relationship) by exposing one or more experimental groups and the results are compared with one or more control groups that are not subject to treatment. The analysis technique used is validity test, reliability test, normality test, paired t test. The results showed the data of social studies subject matter of market material in the pretest and posttest experimental class conducted on eighth grade students of Middle School Kertanegara, Malang showed there were differences in grades. In the control class it is known that students understand after knowing the questionnaire given, the average pretest value of 65.20% while the posttest value of 70.03%, this shows an increase of 4.83%. In the experimental class there are also differences in the results of the pretest and posttest. The average pretest value of 77.00% while the posttest value of 82.03%, this shows an increase of 5.03%. From the results of the control class and the experimental class there was an increase of 0.2%, this was due to students' interest in the TGT type cooperative learning model assisted by the QUACI game. The results of the study on the results of the independent sample t test of the control class and experimental class were 8,103 with a significant level of 0,000, which is <0.05, with an average value of the control class of 70.03 and the experimental class of 87.27, this shows that there are differences in the application of the cooperative learning model type TGT (Team Games Tournament) aided by QUACI games (Quartet Card Innovation) as learning media on "market" material.
Pengaruh Pembelajaran Experiential Learning terhadap Kemampuan Menulis Teks Bahasa Inggris Siswa pada Teks Descriptive di Kelas 10 SMKN 01 Biau Tahun 2020
Authors: Susanti Yuliana Susanti , Sari Ike Dian Puspita 
Published: December 2022

This research aims is to determine the significant effect of using experiential learning to teach descriptive text. The research was conducted on 10th grade at SMK 1 Biau, Sulawesi. The data was taken on february 2020, which the observation proved that students at 10 grade have some obstacles in writing text such us; used passive learning method and less learning motivation. The used of teaching methods were not varied, thus made them felt bored to learn writing. These proved on students' questionnaire. The sample was consisted of 30 students, which divided into two classes, experimental class and control class. AK1 as a experimental class and AK2 as control class. Data technique used random sample data. Experimental class learning was applied experiential method and the control class used conventional teaching. This study used a quantitative experimental pretest posttest control group design. In the data collection technique for mean and STDEV, then t test was used SPSS formula. The results pretest and posttest showed, there were significant scores from both groups. On average the posttest score of the experimental class got 92.27 greater than average score of the control class got 82.00, on independent sample the significant 2-tailed of the posttest class control and experiment around 0.00 <0.05. Thus, Ha was accepted, so that the experiential learning method is effective used in 10 grade students majoring in accounting in writing English text.
Efektifitas Youtube sebagai Media Pembelajaran Digital terhadap Kemampuan Berbicara Siswa di Desa Inggris Singosari
Authors: Wulandari Sri , Hartatik Sri Fatmaning , Ifianti Trisnian 
Published: December 2022

This study aimed at investigating the effectiveness of YouTube as digital learning media to improve students’ speaking proficiency at Desa Inggris Singosari. The participants of this study were 15 trainees of Desa Inggris Singosari. This study used a quantitative method with pre-experimental design. Data were collected using speaking tests and scoring rubric. The speaking tests were analyzed using IBM SPSS Version 22.0. Meanwhile, the scoring rubric the researcher adapted from Brown (2004). After applying YouTube in teaching speaking, it was found that the value of significance (two-tailed) it showed 0.000 was lower than the significant level of 0.05 (0.000 < 0.05). It presented that Ha was accepted and H0 was rejected, it means that YouTube as digital learning media was effective to improve students’ speaking proficiency.

Keywords: YouTube, digital learning media, speaking proficiency
Peran Tindakan Sosial Masyarakat dalam Ritual Pembagunan Rumah Suku di Desa Dubesi Kecamatan Nanaet Dubesi Kabupaten Belu Nusa Tenggara Timur
Authors: Mali Roswitha Eleonora , Setiani Puspita Pebri , Novariyanto Rizky Agung 
Published: December 2022

This study aims to determine the role of community social action in the ritual of building tribal houses and the goals and benefits contained in the ritual of building tribal houses. Role is the position or status of a person in social life who carries out rights and obligations. In the ritual of building a tribal house, each has its own role, especially in the process of carrying out the ritual of building a tribal house. Social action is an individual action that is directed to others and has meaning both for oneself and for others.
The method used in this research is descriptive analysis method. This method is used to be able to understand and provide a clear picture of the problems related to the content of this research. This study uses a qualitative approach because the researcher considers the problems studied are quite complex and dynamic so that the data obtained from the resource persons are collected using a natural method, namely direct interviews with the resource persons so that they get natural answers.
The results of this study indicate that the process of carrying out the ritual of building a tribal house follows four rules that must be carried out, namely: haleka hanematan, Tuda Fos, Hamutuk Ibun hamutuk Lian, and Sona Fahi. And also in the ritual process of implementing the construction of tribal houses, it is divided into four stages, namely the preparation stage, the implementation stage, the inauguration stage and the closing stage. The results of the study also show that the one who plays an important role in the ritual of building a tribal house is the malun because the malun is a person who comes from the descendants of the male ancestor of the founder of the tribal house that is being built.
Data-independent acquisition proteomics reveals circulating biomarkers of coronary chronic total occlusion in humans
Authors: Li Jun , Jiang Xue-Jun , Wang Qun-Hui , Wu Xing-Liang , Qu Zhe , Song Tao , Wan Wei-Guo , Zheng Xiao-Xin , Yi Xin 
Published: December 2022

IntroductionThe pathophysiology of coronary chronic total occlusion (CTO) has not been fully elucidated.MethodsIn the present study, we aimed to investigate the potential plasma biomarkers associated with the pathophysiologic progression of CTO and identify protein dynamics in the plasma of CTO vessels immediately after successful revascularization. We quantitatively analyzed the plasma proteome profiles of controls (CON, n = 10) and patients with CTO pre- and post- percutaneous coronary intervention (PCI) (CTO, n = 10) by data-independent acquisition proteomics. We performed enzyme-linked immunosorbent assay (ELISA) to further confirm the common DEPs in the two-group comparisons (CON vs. CTO and CTO vs. CTO-PCI).ResultsA total of 1936 proteins with 69 differentially expressed proteins (DEPs) were detected in the plasma of patients with CTO through quantitative proteomics analysis. For all these DEPs, gene ontology (GO) analysis and protein-protein interaction (PPI) analysis were performed. The results showed that most of the proteins were related to the negative regulation of proteolysis, regulation of peptidase activity, negative regulation of hydrolase activity, humoral immune response, and lipid location. Furthermore, we identified 1927 proteins with 43 DEPs in the plasma of patients with CTO vessels after immediately successful revascularization compared to pre-PCI. GO analysis revealed that the above DEPs were enriched in the biological processes of extracellular structure organization, protein activation cascade, negative regulation of response to external stimulus, plasminogen activation, and fibrinolysis. More importantly, we generated a Venn diagram to identify the common DEPs in the two-group comparisons. Seven proteins, ADH4, CSF1, galectin, LPL, IGF2, IgH, and LGALS1, were found to be dynamically altered in plasma during the pathophysiological progression of CTO vessels and following successful revascularization, moreover, CSF1 and LGALS1 were validated via ELISA.ConclusionsThe results of this study reveal a dynamic pattern of the molecular response after CTO vessel immediate reperfusion, and identified seven proteins which would be the potential targets for novel therapeutic strategies to prevent coronary CTO.
Identification of PFKFB2 as a key gene for the transition from acute to old myocardial infarction in peripheral blood
Authors: Yang Xiangyu , Li Jie , Hu Xinyao , Zhang Yinzhuang , Kuang Yuanyuan , Liu Yubo , Liu Chenxi , Gao Haodong , Ma Li , Tang Jia , Ma Qilin 
Published: December 2022

ObjectiveThis study aims to analyze the gene expression profile of peripheral blood in different stages of myocardial infarction (MI) by transcriptome sequencing, and to study the gene expression characteristics of peripheral blood after MI.MethodsDifferentially expressed genes (DEGs) and weighted gene co-expression network analysis (WGCNA) were used to identify genes and modules associated with old myocardial infarction (OMI). Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation were applied to analyze the potential functions of genes. Hub genes were identified by Random Forest Classifier. CIBERSORT was used to provide an estimate of the abundance of 22 immune cells in peripheral blood. Quantitative polymerase chain reaction (qPCR) was used to detect gene expression levels in clinical samples. The cellular components (CC) of peripheral blood were counted by an automatic hematology analyzer.ResultsThrough differential gene analysis and co-expression network analysis, 11 candidate genes were obtained. A random forest classifier identified 10 hub genes. Immune cell distribution of peripheral blood was found that T cell CD4 memory resting, NK cells resting, Dendritic cells activated, Mast cells resting, Monocytes and Neutrophils were correlated with OMI. Spearman correlation analysis found that PFKFB2 is related to the above immune cells. Low expression of PFKFB2 in peripheral blood of OMI was detected in clinical samples, and the relationship between PFKFB2 and peripheral blood immune cell counts was analyzed, which showed monocytes were associated with PFKFB2 in our study.ConclusionPFKFB2 was low expressed in OMI, and related to the distribution of immune cells. PFKFB2 may play a key role in reflecting the transition from AMI to OMI, and predicting the distribution of immune cells, which provided a new perspective for improving myocardial fibrosis and adverse remodeling.
Professionalization of science management—Comparing formal education and training across Germany, Poland, and Hungary
Authors: Müller Ursula , Toczyski Piotr , Regös Nora , Pliszczynska Olga , Jankovics Réka 
Published: December 2022

Description of the examined questionsOur goal is to suggest a working definition of “science management” and to explore and systematically compare study programs related to this area. We focus on science management diplomas, short courses and workshops in three countries: Germany, Poland, and Hungary. What is common and what is different in the approaches to science management in three knowledge societies?MethodologyOur method is descriptive and comparative. We use desk research to find out how the programs in science management are structured in three countries and what approaches are specific to them all.ResultsIt became evident that in Germany there are plenty of offerings in terms of specialized study programs and short courses. There is a certain dynamic regarding the interconnectedness of research fields and the institutionalization of education and training. This leads to self-reinforcing dynamics concerning professionalization of science management, although science managers still can be hardly labeled as professionals. In Poland and Hungary there is still not much momentum to the process of professionalization, although first efforts are made. Programs such as European Research Area (ERA)-Fellowship might contribute to the evolution of multi-lateral networks between these countries and Germany. The awareness and broad understanding of science management might spread also in Central and Eastern European countries.ConclusionWe conclude that the impact on the professionalization of science managers in Germany, Poland, and Hungary is unequal. Concerning training and education in Poland and Hungary, this article might be one step toward showing the broadness inherent to the concept of “science management.” It might stimulate more people in Central and Eastern European countries to think about this, to generate knew knowledge and to teach their insights within newly established study programs or short courses.