bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of cardiac surgical support on long-term outcomes of emergent or complex percutaneous coronary intervention cases: a sub-analysis of the SHINANO 5-year registry
Authors: Nakamura Chie , Ebisawa Soichiro , Miura Takashi , Nomi Hidetomo , Kanzaki Yusuke , Yui Hisanori , Maruyama Shusaku , Nagae Ayumu , Ueki Yasushi , Sakai Takahiro , Kato Tamon , Saigusa Tatsuya , Okada Ayako , Motoki Hirohiko , Kuwahara Koichiro 
Published: January 2022

AbstractSignificant improvements in percutaneous coronary intervention (PCI) technology have enabled cardiovascular procedures to be performed without onsite cardiac surgery facilities. However, little is known about the association between onsite cardiac surgical support and long-term outcomes of PCI, particularly among emergent and complex cases. We investigated whether the presence or absence of cardiovascular surgery affects the long-term prognosis after PCI, emergent and complex elective cases. The SHINANO 5-year registry, a prospective, observational, and multicenter cohort study registry in Nagano, Japan, consecutively included 1665 patients who underwent PCI between August 2012 and July 2013. The procedures were performed at 11 hospitals with onsite cardiac surgery facilities [onsite surgery (+) group; n = 1257] and 8 hospitals without onsite cardiac surgery facilities [onsite surgery (−) group; n = 408]. The primary endpoint was all-cause mortality and the secondary endpoint was major adverse cardiac and cerebrovascular events [MACCE: all-cause death, Q-wave myocardial infarction, non-fatal stroke, and target lesion revascularization]. The onsite surgery group (+) had a lower rate of emergent PCI and ST-segment elevation myocardial infarction (40.8% vs. 51.7%, p < 0.01 and 24.9% vs. 39.2%, p < 0.01, respectively), and a higher prevalence of hemodialysis and history of peripheral artery disease (7.6% vs. 2.45%, p < 0.01 and 12.1% vs. 6.9%, p < 0.01, respectively). However, the Kaplan–Meier analysis showed no difference in the 5-year mortality rate (16.4% vs. 15.2%, p = 0.421) and MACCE incidence (31.6% vs. 28.9%, p = 0.354) between the groups. Also, there were no differences in the mortality rate and incidence of MACCE among emergent cases of ST-segment elevation myocardial infarction and complex elective cases who underwent PCI. Long-term outcomes of PCI appear to be comparable between institutions with and without onsite cardiac surgical facilities.
Mesenteric occlusive disease of the inferior mesenteric artery is associated with anastomotic leak after left-sided colon and rectal cancer surgery: a retrospective cohort study
Authors: Arron Melissa N. N. , Broek Richard P. G. ten , Adriaansens Carleen M. E. M. , Bluiminck Stijn , van Wely Bob J. , Ferenschild Floris T. J. , Smits Henk F. M. , van Goor Harry , de Wilt Johannes H. W. , van Petersen André S. 
Published: January 2022

Abstract
Purpose
Anastomotic leak (AL) is a serious complication following colorectal surgery. Atherosclerosis causes inadequate anastomotic perfusion and is suggested to be a risk factor for AL. The aim of this study was to investigate the association of mesenteric occlusive disease on preoperative computed tomography (CT) scan with AL after left-sided colon or rectal cancer surgery.

Methods
This was a retrospective, multicenter cohort study including 1273 patients that underwent left-sided or rectal cancer resection between 2009 and 2018 from three hospitals in the Netherlands. AL patients were 1:1 matched with non-leak patients and preoperative contrast-enhanced CT-scans were retrospectively analyzed for mesenteric atherosclerotic lesions. The main outcome measure was the presence of mesenteric occlusive disease on the preoperative CT-scan.

Results
Anastomotic leak developed in 6% of 1273 patients (N = 76). Low anterior resection and stage I–III disease were statistically significant associated with AL (p = 0.01, p = 0.04). No other statistically significant differences in patient characteristics between AL and non-leak patients were found. A clinically significant stenosis (≥ 70–100%) of the inferior mesenteric artery was statistically significant more frequent present in AL patients, compared to non-leak patients (p < 0.01). No statistically significant differences in the presence of mesenteric occlusive disease of the celiac artery and superior mesenteric artery between AL patients and non-leak patients were found.

Conclusion
Mesenteric occlusive disease of the IMA on preoperative CT-scan is associated with AL after left-sided colon or rectal resection for cancer. Preoperative identification of high-risk patients with a preoperative CT-scan of the mesenteric vasculature might be useful to reduce the risk of AL.
Outcomes of left atrial appendage occlusion vs. non-vitamin K antagonist oral anticoagulants in atrial fibrillation
Authors: Ding Wern Yew , Rivera-Caravaca José Miguel , Fazio-Eynullayeva Elnara , Underhill Paula , Gupta Dhiraj , Marín Francisco , Lip Gregory Y. H. 
Published: January 2022

Abstract
Background
The effects of left atrial appendage (LAA) occlusion compared to non-vitamin K antagonist oral anticoagulant (NOAC) therapy in patients with atrial fibrillation (AF) remain unknown.

Aims
We aimed to evaluate the outcomes in patients with AF who received LAA occlusion vs. NOAC therapy.

Methods
We utilised data from TriNetX which is a global federated health research network currently containing data for 88.5 million patients. ICD-10 codes were employed to identify AF patients treated with either LAA occlusion or NOAC between 1st December 2010 and 17th January 2019. Clinical outcomes of interest were analysed up to 2 years.

Results
108,697 patients were included. Patients who underwent LAA occlusion were younger, more likely to be white Caucasian and male, had a greater incidence of comorbidities, and were less likely to be prescribed other cardiovascular medications. Using propensity score matching, the risk of all-cause mortality was significantly lower among patients who received LAA occlusion compared to NOAC therapy [1.51% vs. 5.60%, RR 0.27 (95% CI 0.14–0.54)], but there were no statistical differences in the composite thrombotic or thromboembolic events [8.17% vs. 7.72%, RR 1.06 (95% CI 0.73–1.53)], ischaemic stroke or TIA [4.69% vs. 5.45%, RR 0.86 (95% CI 0.54–1.38)], venous thromboembolism [1.66% vs. 1.51%, RR 1.10 (95% CI 0.47–2.57)] and intracranial haemorrhage [1.51% vs. 1.51%, RR 1.00 (95% CI 0.42–2.39)].

Conclusion
Overall, LAA occlusion might be a suitable alternative to NOAC therapy for stroke prevention in patients with AF.

Graphical abstract
International practice variation in perioperative laboratory testing in glioblastoma patients—a retrospective cohort study
Authors: Senders Joeky T. , Maas Sybren L. N. , Draaisma Kaspar , McNulty John J. , Ashby Joanna L. , Hofer Imo , van Solinge Wouter W. , Berg Maarten ten , Snijders Tom J. , Seute Tatjana , Robe Pierre A. , Gormley William B. , Smith Timothy R. , Broekman Marike L. D. 
Published: January 2022

Abstract
Purpose
Although standard-of-care has been defined for the treatment of glioblastoma patients, substantial practice variation exists in the day-to-day clinical management. This study aims to compare the use of laboratory tests in the perioperative care of glioblastoma patients between two tertiary academic centers—Brigham and Women’s Hospital (BWH), Boston, USA, and University Medical Center Utrecht (UMCU), Utrecht, the Netherlands.

Methods
All glioblastoma patients treated according to standard-of-care between 2005 and 2013 were included. We compared the number of blood drawings and laboratory tests performed during the 70-day perioperative period using a Poisson regression model, as well as the estimated laboratory costs per patient. Additionally, we compared the likelihood of an abnormal test result using a generalized linear mixed effects model.

Results
After correction for age, sex, IDH1 status, postoperative KPS score, length of stay, and survival status, the number of blood drawings and laboratory tests during the perioperative period were 3.7-fold (p < 0.001) and 4.7-fold (p < 0.001) higher, respectively, in BWH compared to UMCU patients. The estimated median laboratory costs per patient were 82 euros in UMCU and 256 euros in BWH. Furthermore, the likelihood of an abnormal test result was lower in BWH (odds ratio [OR] 0.75, p < 0.001), except when the prior test result was abnormal as well (OR 2.09, p < 0.001).

Conclusions
Our results suggest a substantially lower clinical threshold for ordering laboratory tests in BWH compared to UMCU. Further investigating the clinical consequences of laboratory testing could identify over and underuse, decrease healthcare costs, and reduce unnecessary discomfort that patients are exposed to.
Assessing the wall effects of packed concentric cylinders and angular walls on granular bed porosity
Authors: Bandelt Riess Peter Michael , Briesen Heiko , Schiochet Nasato Daniel 
Published: January 2022

AbstractThe effect of added wall support on granular bed porosity is systematically studied to elucidate performance enhancements in filtration processes achieved by using inserts, as demonstrated experimentally (Bandelt Riess et al. in Chem Eng Technol 2018, 2021). Packed beds of spheres are simulated through discrete element method in cylinders with different internal wall configurations. Three containing systems are generated: concentric cylinders, angular walls, and a combination of both. Variations of particle size and wall friction and thickness are also considered, and the resulting granular bed porosities are analyzed. The porosity increase is proportional to the incorporated wall support; the combination of cylindrical and angular inserts displays the greatest effect (up to 26% increase). The sinusoidal porosity values near the walls are exhibited to clarify the effects. The presented method can change and evaluate granular bed porosity increments, which could lead to filtration process improvements, and the obtained behaviors and profiles can be used to explore additional effects and further systems.
Graphical abstract
Mirror self-recognition in gorillas (Gorilla gorilla gorilla): a review and evaluation of mark test replications and variants
Authors: Murray Lindsay E. , Anderson James R. , Gallup Gordon G. 
Published: January 2022

AbstractMirror self-recognition (MSR), widely regarded as an indicator of self-awareness, has not been demonstrated consistently in gorillas. We aimed to examine this issue by setting out a method to evaluate gorilla self-recognition studies that is objective, quantifiable, and easy to replicate. Using Suarez and Gallup’s (J Hum Evol 10:175–183, 1981) study as a reference point, we drew up a list of 15 methodological criteria and assigned scores to all published studies of gorilla MSR for both methodology and outcomes. Key features of studies finding both mark-directed and spontaneous self-directed responses included visually inaccessible marks, controls for tactile and olfactory cues, subjects who were at least 5 years old, and clearly distinguishing between responses in front of versus away from the mirror. Additional important criteria include videotaping the tests, having more than one subject, subjects with adequate social rearing, reporting post-marking observations with mirror absent, and giving mirror exposure in a social versus individual setting. Our prediction that MSR studies would obtain progressively higher scores as procedures and behavioural coding practices improved over time was supported for methods, but not for outcomes. These findings illustrate that methodological rigour does not guarantee stronger evidence of self-recognition in gorillas; methodological differences alone do not explain the inconsistent evidence for MSR in gorillas. By implication, it might be suggested that, in general, gorillas do not show compelling evidence of MSR. We advocate that future MSR studies incorporate the same criteria to optimize the quality of attempts to clarify the self-recognition abilities of gorillas as well as other species.
3D APT and NOE CEST-MRI of healthy volunteers and patients with non-enhancing glioma at 3 T
Authors: Wu Yulun , Wood Tobias C. , Arzanforoosh Fatemeh , Hernandez-Tamames Juan A. , Barker Gareth J. , Smits Marion , Warnert Esther A. H. 
Published: January 2022

Abstract
Objective
Clinical application of chemical exchange saturation transfer (CEST) can be performed with investigation of amide proton transfer (APT) and nuclear Overhauser enhancement (NOE) effects. Here, we investigated APT- and NOE-weighted imaging based on advanced CEST metrics to map tumor heterogeneity of non-enhancing glioma at 3 T.

Materials and methods
APT- and NOE-weighted maps based on Lorentzian difference (LD) and inverse magnetization transfer ratio (MTRREX) were acquired with a 3D snapshot CEST acquisition at 3 T. Saturation power was investigated first by varying B1 (0.5–2 µT) in 5 healthy volunteers then by applying B1 of 0.5 and 1.5 µT in 10 patients with non-enhancing glioma. Tissue contrast (TC) and contrast-to-noise ratios (CNR) were calculated between glioma and normal appearing white matter (NAWM) and grey matter, in APT- and NOE-weighted images. Volume percentages of the tumor showing hypo/hyperintensity (VPhypo/hyper,CEST) in APT/NOE-weighted images were calculated for each patient.

Results
LD APT resulting from using a B1 of 1.5 µT was found to provide significant positive TCtumor,NAWM and MTRREX NOE (B1 of 1.5 µT) provided significant negative TCtumor,NAWM in tissue differentiation. MTRREX-based NOE imaging under 1.5 µT provided significantly larger VPhypo,CEST than MTRREX APT under 1.5 µT.

Conclusion
This work showed that with a rapid CEST acquisition using a B1 saturation power of 1.5 µT and covering the whole tumor, analysis of both LD APT and MTRREX NOE allows for observing tumor heterogeneity, which will be beneficial in future studies using CEST-MRI to improve imaging diagnostics for non-enhancing glioma.
Phosphorus fluxes in two contrasting forest soils along preferential pathways after experimental N and P additions
Authors: Julich Dorit , Makowski Vera , Feger Karl-Heinz , Julich Stefan 
Published: January 2022

AbstractThe assessment of impacts of an altered nutrient availability, e.g. as caused by consistently high atmospheric nitrogen (N) deposition, on ecosystem phosphorus (P) nutrition requires understanding of P fluxes. However, the P translocation in forest soils is not well understood and soil P fluxes based on actual measurements are rarely available. Therefore, the aims of this study were to (1) examine the effects of experimental N, P, and P+N additions on P fluxes via preferential flow as dominant transport pathway (PFPs) for P transport in forest soils; and (2) determine whether these effects varied with sites of contrasting P status (loamy high P/sandy low P). During artificial rainfall experiments, we quantified the P fluxes in three soil depths and statistically analyzed effects by application of linear mixed effects modeling. Our results show that the magnitude of P fluxes is highly variable: In some cases, water and consequently P has not reached the collection depth. By contrast, in soils with a well-developed connection of PFPs throughout the profile fluxes up to 4.5 mg P m−2 per experiment (within 8 h, no P addition) were observed. The results furthermore support the assumption that the contrasting P nutrition strategies strongly affected P fluxes, while also the response to N and P addition markedly differed between the sites. As a consequence, the main factors determining P translocation in forest soils under altered nutrient availability are the spatio-temporal patterns of PFPs through soil columns in combination with the P nutrition strategy of the ecosystem.
Geographic determinants of colorectal cancer in Louisiana
Authors: Danos Denise , Leonardi Claudia , Wu Xiao-Cheng 
Published: January 2022

Abstract
Purpose
Currently, rural residents in the United States (US) experience a greater cancer burden for tobacco-related cancers and cancers that can be prevented by screening. We aim to characterize geographic determinants of colorectal cancer (CRC) incidence in Louisiana due to rural residence and other known geographic risk factors, area socioeconomic status (SES), and cultural region (Acadian or French-speaking).

Methods
Primary colorectal cancer diagnosed among adults 30 years and older in 2008–2017 were obtained from the Louisiana Tumor Registry. Population and social and economic data were obtained from US Census American Community Survey. Rural areas were defined using US Department of Agriculture 2010 rural–urban commuting area codes. Estimates of relative risk (RR) were obtained from multilevel binomial regression models of incidence.

Results
The study population was 16.1% rural, 18.4% low SES, and 17.9% Acadian. Risk of CRC was greater among rural white residents (RR Women: 1.09(1.02–1.16), RR Men: 1.11(1.04–1.18)). Low SES was associated with increased CRC for all demographic groups, with excess risk ranging from 8% in Black men (RR: 1.08(1.01–1.16)) to 16% in white men (RR: 1.16(1.08–1.24)). Increased risk in the Acadian region was greatest for Black men (RR: 1.21(1.10–1.33)) and women (RR: 1.21(1.09–1.33)). Rural–urban disparities in CRC were no longer significant after controlling for SES and Acadian region.

Conclusion
SES remains a significant determinant of CRC disparities in Louisiana and may contribute to observed rural–urban disparities in the state. While the intersectionality of CRC risk factors is complex, we have confirmed a robust regional disparity for the Acadian region of Louisiana.
Dynamics of bacterial blight disease in resistant and susceptible rice varieties
Authors: Niones Jennifer T. , Sharp Ryan T. , Donayre Dindo King M. , Oreiro Eula Gems M. , Milne Alice E. , Oliva Ricardo 
Published: January 2022

AbstractBacterial blight (X. oryzae pv. oryzae) is a serious disease in rice across the world. To better control the disease, it is important to understand its epidemiology and how key aspects of this (e.g. infection efficiency, and spatial spread) change according to environment (e.g. local site conditions and season), management, and in particular, variety resistance. To explore this, we analysed data on the disease progress on resistant and susceptible varieties of rice grown at four sites in the Philippines across five seasons using a combination of mechanistic modelling and statistical analysis. Disease incidence was generally lower in the resistant variety. However, we found no evidence that the primary infection efficiency was lower in resistant varieties, suggesting that differences were largely due to reduced secondary spread. Despite secondary spread being attributed to splash dispersal which is exacerbated by wind and rain, the wetter sites of Pila and Victoria in south Luzon tended to have lower infection rates than the drier sites in central Luzon. Likewise, we found spread in the dry season can be substantial and should therefore not be ignored. In fact, we found site to be a greater determinant of the number of infection attempts suggesting that other environmental and management factors had greater effect on the disease than climate. Primary infection was characterised by spatially-random observations of disease incidence. As the season progressed, we observed an emerging short-range (1.6 m–4 m) spatial structure suggesting secondary spread was predominantly short-range, particularly where the resistant variety was grown.
Convexity and level sets for interval-valued fuzzy sets
Authors: Huidobro Pedro , Alonso Pedro , Janiš Vladimír , Montes Susana 
Published: January 2022

AbstractConvexity is a deeply studied concept since it is very useful in many fields of mathematics, like optimization. When we deal with imprecision, the convexity is required as well and some important applications can be found fuzzy optimization, in particular convexity of fuzzy sets. In this paper we have extended the notion of convexity for interval-valued fuzzy sets in order to be able to cover some wider area of imprecision. We show some of its interesting properties, and study the preservation under the intersection and the cutworthy property. Finally, we applied convexity to decision-making problems.
Rethinking employability: how students build on interest in a subject to plan a career
Authors: Quinlan Kathleen M. , Renninger K. Ann 
Published: January 2022

AbstractAs universities prioritise employability, there is increased attention to promoting students’ career decidedness. In this mixed method, cross-sectional study, we explore whether and how students’ interest in their academic subject affects their career decidedness. Using surveys of 428 undergraduates studying sciences in a UK university (60% F, average age = 19.9) and case examples from follow-up interviews with 15 students, we examine students’ interest development and its relation to their career decidedness and their desire for meaningful, interesting work. Findings showed that most students who were studying science in university had a well-developed interest that had motivated their choice of programme, and their subject interest and career decidedness were linked. Regression analyses indicated that students’ interest in their subject was a significant predictor of career decidedness, mediated by students’ desire to pursue that interest in their career. Open-ended comments on the surveys suggested that decidedness was informed by coursework, proactive career exploration, work experience, interest, feasibility, and familial contacts. Interviews confirmed these factors and illustrated how they contributed to students’ career decidedness. We propose implications for academics and career counsellors who might help students refine their interest by considering connections between their academic subject, interest, and related career options. We argue that educators and policy-makers need to reframe employability interventions and think beyond teaching students skills or attributes that lead to employment. Educators can start with students’ interest in their subject and support students’ exploration of how they can continue to pursue that interest in various careers.