bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socialization of Earthquake Disaster Mitigation to Elementary School Students Through Pocket Books
Authors: Nurjanah Siti 
Published: March 2022

Abstract. The implementation of this Community Service (PkM) activity aims to increase the understanding of elementary school students on the attitudes that must be carried out before, during, and after the earthquake disaster. Through this PkM activity, students are expected to be able to, 1) have basic knowledge about the steps in responding to disasters properly and correctly; 2) students have an understanding of the attitude that must be done in the event of a disaster; and 3) students have an understanding of attitudes that must be done after a disaster occurs. The training participants were 30 students of SD MIN 1 Ambon. The materials presented at the time of socialization were 1) things to be prepared before a disaster occurred, 2) strategies to be implemented during a disaster, and 3) strategies to be implemented after a disaster occurred. This PkM activity was carried out through lecture methods, and demonstrations using the disaster response pocket book. The results of the training obtained are 1) students gain basic knowledge about earthquake disaster mitigation before a disaster occurs, 2) students have an understanding of attitudes that must be taken when a disaster occurs, and 3) students have an understanding of what to do after a disaster occurs. Referring to the results of this PkM activity, the school should participate more actively in carrying out socialization activities so that students have more knowledge and understanding of earthquake disaster mitigation. Keywords: mitigation, earthquake, students
Islamic Financial Literascy For Members Majelis Ta’lim Raudatul Jannah in Tulehu Village
Authors: Pelupessy Fatmah Watty 
Published: March 2022

Abstract: This comminity service activity (PkM) aims to provide understanding to members of the Majelis Ta’lim Raudatu Jannah about islamic finance as well as contracts and products in islamic banking located in Tulehu village. This activity is carried out by providing socialization regarding islamic financial institutions (especially isslamic banking). The socialization activity was followed by sharing and discussion activities regarding the material that had been delivered. Keywords: Literacy, Islamic FinanceAbstrak: Kegiatan pengabdian kepada masyarakat (PkM) ini bertujuan untuk memberikan pemahaman kepada anggota majelis ta’lim raudatul jannah tentang keuangan syariah serta akad dan produk-produk dalam perbankan syariah.kegiatan ini melibatkan seluruh anggota Majelis Ta’lim Raudatul Jannah yang berlokasi di Desa Tulehu. Kegiatan ini dilaksanakan dengan memberikan sosialisasi mengenai lembaga keuangan syariah (khususnya perbankan syariah). Kegiatan sosialisasi dilanjutkan dengan kegiatan sharing dan diskusi mengenai materi yang telah disampaikan. Kata kunci: Literasi, Keuangan Syariah
Pembuatan Video Tempat-Tempat Angker di Tanjungpinang
Authors: Kho Jensen , Deli Deli 
Published: March 2022

Dengan perkembangan teknologi yang sangat maju sekarang ini banyak hal yang sudah sangat berkembang salah satunya adalah media video. Video adalah sebuah media pengirim pesan yang mengandung gambar yang bergerak dan suara. Istilah video berasal dari bahasa latin yaitu dari kata vidi atau visum yang artinya melihat atau mempunyai daya penglihatan. Media video sekarang banyak dimanfaatkan untuk mempromosikan sebuah produk atau tempat-tempat yang belum diketahui oleh banyak orang,contohnya seperti mempromosikan tempat-tempat angker disebuah kota yang tidak diketahui oleh banyak orang. Promosi adalah sebuah kegiatan yang dilakukan untuk memperkenalkan sebuah produk atau tempat yang bertujuan untuk meningkatkan omzet penjualan. Peneliti akan merancang Haunted Place Videography dengan menggunakan metode R&D yang mengacu pada model IDI. Tempat angker terkadang memiliki daya tarik tersendiri, terutama untuk orang-orang yang suka atau penasaran dengan dunia lain. Tempat angker adalah tempat yang diyakini mempunyai kisah mistis dan diperkirakan dihuni oleh makhluk-makhluk halus. Video ini dirancang berdasarkan data yang diperoleh oleh peneliti. Data didapatkan oleh peneliti dari hasil observasi dan research market. Luaran atau hasil dari perancangan ini adalah sebuah video tentang tempat-tempat horror di Kota Tanjungpinang. Hasil dari perancangan ini diharapkan dapat membantu mempromosikan tempat-tempat tersebut dan juga para wisatawan gelap yang tertarik dengan tempat tersebut.
Biomechanical Properties of Mouse Carotid Arteries With Diet-Induced Metabolic Syndrome and Aging
Authors: Gkousioudi Anastasia , Yu Xunjie , Ferruzzi Jacopo , Qian Juncheng , Wainford Richard D. , Seta Francesca , Zhang Yanhang 
Published: March 2022

Metabolic syndrome increases the risk of cardiovascular diseases. Arteries gradually stiffen with aging; however, it can be worsened by the presence of conditions associated with metabolic syndrome. In this study, we investigated the combined effects of diet-induced metabolic syndrome and aging on the biomechanical properties of mouse common carotid arteries (CCA). Male mice at 2 months of age were fed a normal or a high fat and high sucrose (HFHS) diet for 2 (young group), 8 (adult group) and 18–20 (old group) months. CCAs were excised and subjected to in vitro biaxial inflation-extension tests and the Cauchy stress-stretch relationships were determined in both the circumferential and longitudinal directions. The elastic energy storage of CCAs was obtained using a four-fiber family constitutive model, while the material stiffness in the circumferential and longitudinal directions was computed. Our study showed that aging is a dominant factor affecting arterial remodeling in the adult and old mice, to a similar extent, with stiffening manifested with a significantly reduced capability of energy storage by ∼50% (p &lt; 0.05) and decreases in material stiffness and stress (p &lt; 0.05), regardless of diet. On the other hand, high fat high sucrose diet resulted in an accelerated arterial remodeling in the young group at pre-diabetic stage by affecting the circumferential material stiffness and stress (p &lt; 0.05), which was eventually overshadowed by aging progression. These findings have important implications on the effects of metabolic syndrome on elastic arteries in the younger populations.
Caring for Young Adults With Diabetes in the Adult Care Setting: Summary of a Multidisciplinary Roundtable
Authors: Toschi Elena , Leblanc Jennifer , Hafida Samar , Mehta Sanjeev , Ritholz Marilyn , Gabbay Robert , Laffel Lori 
Published: March 2022

AimsA multidisciplinary team of clinicians and researchers, patients and family members, and representative from national advocacy groups and research organization met to review the literature, highlight gaps, and identify best practices to improve adult care delivery for young adults (YA) with diabetes.MethodsThe participants prepared presentations in advance, rotated through sessions, and contributed to group discussions in three areas: physical health, mental health, and quality of life (QoL). Session moderators and scribes used thematic analysis to summarize discussions for each topic.ResultsThematic analysis revealed four foci for addressing physical health, mental health and QoL: 1) best practices to facilitate the process of transfer; 2) age-specific curricula and guidelines for prevention and management of comorbidities and complications; 3) collaboration with behavioral health clinicians to address diabetes distress and mental health disorders; and 4) research on the impact of diabetes on QoL in YA.ConclusionThere was substantial interest and need among adult clinicians to work in concert with pediatric and mental health professionals to identify best practices and future directions to improve healthcare process and diabetes-related outcome measures in YA with diabetes.
Programmed Topographic Substrates for Studying Roughness Gradient-Dependent Cell Migration Using Two-Photon Polymerization
Authors: Shivani Subhashree , Hsu Yu-Hsiang , Lee Cheng-Je , Cheong Chi-Sheng , Chung Tien-Tung , Wang An-Bang 
Published: March 2022

The mediation of the extracellular matrix is one of the major environmental cues to direct cell migration, such as stiffness-dependent durotaxis and adhesiveness-dependent haptotaxis. In this study, we explore another possible contact guidance: roughness dependent topotaxis. Different from previously reported studies on topotaxis that use standard photolithography to create micron or submicron structures that have identical height and different spatial densities, we develop a new method to programmatically fabricate substrates with different patterns of surface roughness using two-photon polymerization. Surface roughness ranging from 0.29 to 1.11 μm can be created by controlling the voxel distance between adjacently cured ellipsoid voxels. Patterned Ormocomp® masters are transferred to polypropylene films using the nanoimprinting method for cell migration study. Our experimental results suggest that MG63 cells can sense the spatial distribution of their underlying extracellar roughness and modulate their migration velocity and direction. Three characteristic behaviors were identified. First, cells have a higher migration velocity on substrates with higher roughness. Second, cells preferred to migrate from regions of higher roughness to lower roughness, and their migration velocity also decreased with descending roughness. Third, the migration velocity remained unchanged on the lower roughness range on a graded substrate with a steeper roughness. The last cell migration characteristic suggests the steepness of the roughness gradient can be another environmental cue in addition to surface roughness. Finally, the combination of two-photon polymerization and nanoimprint methods could become a new fabrication methodology to create better 3D intricate structures for exploring topotactic cell migrations.
In Situ Reduced Graphene Oxide and Polyvinyl Alcohol Nanocomposites With Enhanced Multiple Properties
Authors: Hu Wenwen , Liu Shuhan , Wang Zhonghai , Feng Xianjing , Gao Ming , Song Fangming 
Published: March 2022

The nanocomposites formed by graphene oxide (GO) and carbazate-modified polyvinyl alcohol (PVA-N) were developed to investigate their multiple properties for wide applications. Their physicochemical characterizations confirmed that the in situ reduced GO (rGO) not only decreased the crystallization but also induced the porous structures inside the nanocomposites. Significantly, it revealed that the comprehensive performance of PVA-N2-2%GO consisted of PVA-N2 with the carbazate degree of substitution (DS) of 7% and the weight ratio (wt%) of 2% GO displayed 79% of tensile elongation and tensile strength of 5.96 N/mm2 (MPa) by tensile testing, glass transition temperature (Tg) of 60.8°C and decomposition temperature (Td) of 303.5°C by TGA and DSC, surface contact angle at 89.4 ± 2.1°, and electrical conductivity of 9.95 × 10−11 S/cm. The abovementioned comprehensive performance was enhanced with the increased amount of in situ rGO, contributed by the high DS of the carbazate group in PVA-N and high amount of GO. The rGO by in situ reduction was the main driving force for enhancing the multiple properties inside the nanocomposites.
Nutrient Management Drives the Direction and Magnitude of Nitrous Oxide Flux in Crop Residue-Returned Soil Under Different Soil Moisture
Authors: Lenka Sangeeta , Choudhary Rajesh , Lenka Narendra Kumar , Saha Jayant Kumar , Amat Dolamani , Patra Ashok Kumar , Gami Vijay , Singh Dharmendra 
Published: March 2022

Crop residues as key organic carbon inputs have the potential for soil carbon sequestration. However, previous studies have shown an inconsistent effect of residue return on the direction and magnitude of soil nitrous oxide (N2O) emission. We used a laboratory-based soil incubation study to test the response of N2O emission to crop residue type, soil moisture, and how nutrient management modulates these responses. In this study, we incorporated crop residues with different qualities (wheat, rice, soybean, and maize) at two soil moisture contents {80% field capacity (FC) and 60% FC} and under seven nutrient levels: N0P0K0 (no nutrients), N0PK, N100PK, N150PK, N100PK + manure@ 5 Mg ha−1, N100PK + biochar@ 5 Mg ha−1, and N150PK + biochar@ 5 Mg ha−1. The results demonstrated significant (p &lt; 0.01) differences in the magnitude of N2O emissions among treatments. However, only the interaction effect of residue × nutrient and nutrient × moisture was significant (p &lt; 0.05). N100PK and N150PK at 80% FC mitigated N2O emission by approximately 20% in wheat residue-amended soil (cf. control soil without residue). In contrast, maize residue amendment (cf. control soil) increased N2O emission by 130% under N0P0K0 and 80% FC. Residue effects were negatively correlated with the C:N ratio, and a strong positive correlation (p &lt; 0.01) was obtained between N2O emission and CO2 respiration, labile carbon, mineral N, and residue total nitrogen (TN). When no nutrients were added, N2O emission was higher in residue returned soil. However, cumulative fluxes of N2O decreased by 6–17% when maize and wheat residues (cf. control soil) were applied with nutrients. Negative fluxes of N2O indicating consumption were observed in every treatment after 57 days of incubation and were most pronounced in control soil without residue and nutrients. Decreasing the soil moisture from 80% FC to 60% FC, the N2O consumption rate increased by 6.6 times across residue types and nutrient management. The regression analysis and structural equation modeling (SEM) results showed that residue TN, soil CO2 emission, NO3-N, and labile SOC were the key predictor variables and could explain 82% variability in the soil N2O emission in the Vertisols of Central India. The results suggested that nutrient addition (NPK) could alter the magnitude and direction of soil N2O flux by residue type and soil moisture by influencing the underlying soil microbial processes of the C and N cycle in the Vertisol of subtropical India.
Desmoplastic Reaction, Immune Cell Response, and Prognosis in Colorectal Cancer
Authors: Akimoto Naohiko , Väyrynen Juha P. , Zhao Melissa , Ugai Tomotaka , Fujiyoshi Kenji , Borowsky Jennifer , Zhong Rong , Haruki Koichiro , Arima Kota , Lau Mai Chan , Kishikawa Junko , Twombly Tyler S. , Takashima Yasutoshi , Song Mingyang , Zhang Xuehong , Wu Kana , Chan Andrew T. , Meyerhardt Jeffrey A. , Giannakis Marios , Nowak Jonathan A. , Ogino Shuji 
Published: March 2022

BackgroundThe relationships between tumor stromal features (such as desmoplastic reaction, myxoid stroma, and keloid-like collagen bundles) and immune cells in the colorectal carcinoma microenvironment have not yet been fully characterized.MethodsIn 908 tumors with available tissue among 4,465 incident colorectal adenocarcinoma cases in two prospective cohort studies, we examined desmoplastic reaction, myxoid stroma, and keloid-like collagen bundles. We conducted multiplex immunofluorescence for T cells [CD3, CD4, CD8, CD45RO (PTPRC), and FOXP3] and for macrophages [CD68, CD86, IRF5, MAF, and MRC1 (CD206)]. We used the inverse probability weighting method and the 4,465 incident cancer cases to adjust for selection bias.ResultsImmature desmoplastic reaction was associated with lower densities of intraepithelial CD3+CD8+CD45RO+ cells [multivariable odds ratio (OR) for the highest (vs. lowest) density category, 0.43; 95% confidence interval (CI), 0.29–0.62; Ptrend &lt;0.0001] and stromal M1-like macrophages [the corresponding OR, 0.44; 95% CI, 0.28–0.70; Ptrend = 0.0011]. Similar relations were observed for myxoid stroma [intraepithelial CD3+CD8+CD45RO+ cells (Ptrend &lt;0.0001) and stromal M1-like macrophages (Ptrend = 0.0007)] and for keloid-like collagen bundles (Ptrend &lt;0.0001 for intraepithelial CD3+CD8+CD45RO+ cells). In colorectal cancer-specific survival analyses, multivariable-adjusted hazard ratios (with 95% confidence intervals) were 0.32 (0.23–0.44; Ptrend &lt;0.0001) for mature (vs. immature) desmoplastic reaction, 0.25 (0.16–0.39; Ptrend &lt;0.0001) for absent (vs. marked) myxoid stroma, and 0.12 (0.05–0.28; Ptrend &lt;0.0001) for absent (vs. marked) keloid-like collagen bundles.ConclusionsImmature desmoplastic reaction and myxoid stroma were associated with lower densities of tumor intraepithelial memory cytotoxic T cells and stromal M1-like macrophages, likely reflecting interactions between tumor, immune, and stromal cells in the colorectal tumor microenvironment.
Identification of Immune-Related Gene Signature and Prediction of CeRNA Network in Active Ulcerative Colitis
Authors: Xu Mengmeng , Kong Ying , Chen Nannan , Peng Wenlong , Zi Ruidong , Jiang Manman , Zhu Jinfeng , Wang Yuting , Yue Jicheng , Lv Jinrong , Zeng Yuanyuan , Chin Y. Eugene 
Published: March 2022

BackgroundUlcerative colitis (UC) is an inflammatory disease of the intestinal mucosa, and its incidence is steadily increasing worldwide. Intestinal immune dysfunction has been identified as a central event in UC pathogenesis. However, the underlying mechanisms that regulate dysfunctional immune cells and inflammatory phenotype remain to be fully elucidated.MethodsTranscriptome profiling of intestinal mucosa biopsies were downloaded from the GEO database. Robust Rank Aggregation (RRA) analysis was performed to identify statistically changed genes and differentially expressed genes (DEGs). Gene Set Enrichment Analysis (GSEA), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to explore potential biological mechanisms. CIBERSORT was used to evaluate the proportion of 22 immune cells in biopsies. Weighted co-expression network analysis (WGCNA) was used to determine key module-related clinical traits. Protein-Protein Interaction (PPI) network and Cytoscape were performed to explore protein interaction network and screen hub genes. We used a validation cohort and colitis mouse model to validate hub genes. Several online websites were used to predict competing endogenous RNA (ceRNA) network.ResultsRRA integrated analysis revealed 1838 statistically changed genes from four training cohorts (adj. p-value &lt; 0.05). GSEA showed that statistically changed genes were enriched in the innate immune system. CIBERSORT analysis uncovered an increase in activated dendritic cells (DCs) and M1 macrophages. The red module of WGCNA was considered the most critical module related to active UC. Based on the results of the PPI network and Cytoscape analyses, we identified six critical genes and transcription factor NF-κB. RT-PCR revealed that andrographolide (AGP) significantly inhibited the expression of hub genes. Finally, we identified XIST and three miRNAs (miR-9-5p, miR-129-5p, and miR-340-5p) as therapeutic targets.ConclusionsOur integrated analysis identified four hub genes (CXCL1, IL1B, MMP1, and MMP10) regulated by NF-κB. We further revealed that AGP decreased the expression of hub genes by inhibiting NF-κB activation. Lastly, we predicted the involvement of ceRNA network in the regulation of NF-κB expression. Collectively, our results provide valuable information in understanding the molecular mechanisms of active UC. Furthermore, we predict the use of AGP and small RNA combination for the treatment of UC.
Impact of the COVID-19 Pandemic on Corneal Transplantation: A Report From the Italian Association of Eye Banks
Authors: Mencucci Rita , Cennamo Michela , Ponzin Diego , Genzano Besso Federico , Pocobelli Giulio , Buzzi Matilde , Nucci Carlo , Aiello Francesco 
Published: March 2022

PurposeTo analyze the impact of COVID-19 on Italian corneal transplantation from March-2020 to February 2021 compared to the same timeframe of the 2 previous years, in order to identify potential consequences of a global pandemic on corneal procurement and transplantation services during this time.MethodsThis national, multicentric, retrospective cohort study evaluated data collected from 12 (100%) Italian eye banks from March 2020 to February 2021 (Group A). The number of tissues collected, distributed and discarded were compared with the same time-frame of the 2 previous years: 2019 and 2018 (group B and C, respectively). The different type of transplants performed were reported. Data were analyzed using a non-parametric Friedman test.ResultsCorneal procurement and the percentage of distributed tissues reduced in 2020 by more than 30 and 15%, respectively, compared to the 2 previous years. During the pandemic corneal transplant surgery showed only a modest drop: the number of the penetrating keratoplasties (PKs) and the anterior lamellar keratoplasties (ALKs) decreased by about 30 and 20% in comparison with groups B and C, respectively; between the Endothelial Keratoplasties (EKs), the Descemet membrane endothelial keratoplasty (DMEK) increased slightly from March 2020 to February 2021.ConclusionsItaly was one of the first countries most affected by the outbreak of COVID-19, and the Italian government adopted severe measures to limit viral transmission. The pandemic generated several implications in corneal transplant activity during the first lockdown. Then an efficacious reaction with constant, vigorous work led to a resumption of transplant surgery to a near-normal standard. The increase of EKs, despite the pandemic, is a sign that the advance in corneal transplantation has gone ahead and it continues to evolve.
A Bibliometric Analysis of Pulmonary Alveolar Proteinosis From 2001 to 2021
Authors: Liu Shixu , Cui Xiangning , Xia Kun , Wang Dandan , Han Jing , Yao Xiaoyan , Liu Xiaohong , Bian Lingjie , Zhang Jinzhi , Li Guangxi 
Published: March 2022

BackgroundPulmonary alveolar proteinosis (PAP) is a rare syndrome first described by Rosen et al. in 1958. Despite our considerably evolved understanding of PAP over the past decades, no bibliometric studies have been reported on this field. We aimed to analyze and visualize the research hotspots and current trends of the PAP research field using a bibliometric analysis to help understand the future development of basic and clinical research.MethodsThe literature regarding PAP was culled from the Web of Science Core Collection (WoSCC) database. Data were extracted from the relevant articles and visually analyzed using CiteSpace and VOSviewer software.ResultsNine hundred and nine qualifying articles were included in the analysis. Publications regarding PAP increased over time. These articles mainly come from 407 institutions of 57 countries. The leading countries were the USA and Japan. University of Cincinnati (USA) and Niigata University (Japan) featured the highest number of publications among all institutions. Bruce C Trapnell exerts a significant publication impact and has made the most outstanding contributions in the field of PAP. American Journal of Physiology-Lung Cellular and Molecular Physiology was the journal with the most publications, and American Journal of Respiratory and Critical Care Medicine was the most commonly cited journal. All the top 5 co-cited journals belong to Q1. Keyword citation bursts revealed that inflammation, deficiency, tissue resident macrophage, classification, autoimmune pulmonary alveolar proteinosis, sarcoidosis, gm csf, high resolution ct, and fetal monocyte were the emerging research hotspots.ConclusionResearch on PAP is prosperous. International cooperation is also expected to deepen and strengthen in the future. Our results indicated that the etiology and pathogenesis of PAP, current and emerging therapies, especially the novel pathogenesis-based options will remain research hotspots in the future.