bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silicosis With Sarcoid-like Reaction Complicated by End-stage Renal Failure From Exposure to Bentonite Cat Litter: a Case Report
Authors: Hubska Joanna , Shahnazaryan Urszula , Rosłon Marek , Szczepankiewicz Benedykt , Nikoforow Kostiantyn , Pisarek Marcin , Barnaś Małgorzata , Ambroziak Urszula 
Published: March 2022

Abstract
BackgroundBentonite cat litter is one of the most popular types of litter used in cat litter boxes worldwide. One of its components is crystalline silica, which when inhaled is a risk factor for silicosis. While silicosis is considered an occupational lung disease, it seems that individuals with no occupational exposure, such as cat owners, may also be affected. In this case report we present an unusual case of chronic silicosis with sarcoid-like reaction complicated by end-stage renal failure from exposure to bentonite cat litter. Case presentationA 44-year-old woman was admitted to the hospital with end-stage renal failure, productive cough and decreased exercise tolerance. On evaluation, a transbronchial lung biopsy was performed. The X-ray photoelectron spectroscopy revealed the presence of silicon in the lung tissue specimen, as well as in the patient’s cat litter. A detailed patient’s history excluded occupational exposure to crystalline silica, however she acknowledged that she had owned 9 cats at home. In a 44m2 apartment, she had had 9 cat litter boxes, which all had been filled with bentonite cat litter for 18 years. After an extensive workup, a diagnosis of chronic silicosis with sarcoid-like reaction complicated by end-stage renal failure from exposure to bentonite cat litter was made. Renal deterioration appeared to result from chronic hypercalcemia, which was a consequence of extra-renal overproduction of calcitriol in activated alveolar macrophages, frequently seen in granulomatous diseases.ConclusionsOur patient had an abnormally large and longtime exposure, but similar health complications may occur, for example, in workers in the zoological industry. It seems reasonable to consider our case report as a strong call for bentonite cat litter manufacturers to place on the packaging information on potential health complications, along with a recommendation to use protective masks when cleaning the litter box.
Comparison of the Predictive Ability of Clinical Frailty Scale and Hospital Frailty Risk Score to Determine Long-Term Survival in Critically Ill Patients: A Multicentre Retrospective Cohort Study
Authors: Subramaniam Ashwin , Ueno Ryo , Tiruvoipati Ravindranath , Srika Velandai , Bailey Michael , Pilcher David 
Published: March 2022

Abstract
Background: The Clinical Frailty Scale (CFS) is the most commonly used frailty measure in intensive care unit (ICU) patients. The hospital frailty risk score (HFRS) was recently proposed for the quantification of frailty. We aimed to compare the HFRS with the CFS in critically ill patients in predicting long-term survival up to one year following ICU admission. Methods: In this retrospective multicentre cohort study from 16 public ICUs in the state of Victoria, Australia between 1st January 2017 and 31st June 2018, ICU admission episodes listed in the Australian and New Zealand Intensive Care Society Adult Patient Database registry with a documented CFS, which had been linked with the Victorian Admitted Episode Dataset and the Victorian Death Index were examined. The HFRS was calculated for each patient using ﻿the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes that represented pre-existing conditions at the time of index hospital admission. Descriptive methods, Cox proportional hazards and area under the receiver operating characteristic (AUROC) were used to investigate the association between each frailty score and long-term survival up to 1 year, after adjusting for confounders including sex and baseline severity of illness on admission to ICU (Australia New Zealand risk-of-death, ANZROD). Results: 7,001 ICU patients with both frailty measures were analysed. The overall median (IQR) age was 63.7 (49.1-74.0) years; 59.5% (n=4,166) were male; the median (IQR) APACHE II score 14 (10-20). Almost half (46.7%, n=3,266) were mechanically ventilated. The hospital mortality was 9.5% (n=642) and 1-year mortality was 14.4% (n=1,005). HFRS correlated weakly with CFS (Spearman’s rho 0.13 (95%CI: 0.10-0.15) and had a poor agreement (kappa=0.12, 95%CI: 0.10-0.15). Both frailty measures predicted 1-year survival after adjusting for confounders, CFS (HR=1.26, 95%CI: 1.21-1.31) and HFRS (HR=1.08, 95%CI: 1.02-1.15). The CFS had better discrimination of 1-year mortality than HFRS (AUROC 0.66 vs 0.63 p<0.0001).Conclusion: Both HFRS and CFS independently predicted up to 1-year survival following an ICU admission with moderate discrimination. The CFS was a better predictor of 1-year survival than the HFRS. Trial Registration: Not applicable
Bioactive metabolites of edible mushrooms efficacious against androgenic alopecia: Targeting SRD5A2 using computational approach
Authors: Tiwari Abhay , Kumar Sushil , Choudhir Gourav , Singh Garima , Gangwa Upanshu , Sharma Vasudha , Srivas Rupesh K. , Sharma Satyawati 
Published: March 2022

Abstract
IntroductionAndrogenic alopecia (AGA), the scalp hair loss, occurs due to the hyperactivity of steroid 5α-reductase2 (SRD5A2), which metabolizes testosterone into 5α-dihydroxytestosterone. Finasteride, an FDA-approved drug-producing many side effects, is a commonly used competitive inhibitor for SRD5A2 to treat AGA. As a number of mushrooms species have been used to treat patients having hair loss problems since ancient times, in the present paper, the bioactive metabolites in mushrooms were computationally screened to assess SRD5A2 inhibitory properties and compared with Finasteride.MethodologyA virtual screening approach in conjunction with molecular dynamics simulation and MMPBSA methods have been applied to identify potential inhibitors against SRD5A2. SwissADME tool and AutoDock Vina were used to screen the library of 156 bioactive mushroom metabolites. All MD simulations were carried out using GROMACS 5.1.4 suite and GROMOS96 43a1 force field. The stability of SRD5A-ligand complexes was determined in terms of RMSD, RMSF, Rg, SASA, and hydrogen bonding. The binding energy of complexes was calculated using MMPBSA.Results and ConclusionVirtual screening and MD simulation studies revealed that out of the 156 metabolites, three bioactives, i.e., Zhankuic acid A (-11.5 kcal/mol), Sterenin M (-10.4 kcal/mol), Melleolide K (-10.2 kcal/mol), and drug Finasteride (-4.3 Kcal/mol) having the least binding energy are the potential inhibitors of SRD5A2. These molecules also exhibited stable interaction with SRD5A2 during MD simulation. This study will pave the way for the experimental evaluation and validation of medicinal potentials of screened mushrooms compounds to treat androgenic alopecia.
Two types of anesthesia and Hemodynamic changes in Patients over 60 years of age who need artificial femoral head replacement: a retrospective cohort study
Authors: Ke Weiqi , WANG Yuting , GUO Xukeng , HUANG Ronghua , ZHANG Xiangdong , WANG Weikai , JI Xuan , ZHUANG Shaohui 
Published: March 2022

Abstract
Background:Artificial femoral head replacement is one of the most effective methods for treatment of severe diseases of femoral joint in the elderly. The ideal anesthetic effect is one of the key elements for the success of the operation because it brings fast recovery. However, the multiple comorbidities of the elder patients make them too weak to tolerate the hemodynamic changes after anesthesia. Objective:To compare the post-anesthetic hemodynamic changes between combined lumbar plexus and sciatic nerve block(CLPSB) and combined spinal and epidural anesthesia(CSEA) in elderly patients undergoing unilateral artificial femoral head replacement.Methods:We reviewed records of the patients who aged over 60 years old (age 62-103 years) and received unilateral artificial femoral head replacement. 477 patients were included and divided into CLPSB group (n=90) and CSEA group (n=387). The primary outcome was comparison of the hemodynamic changes after anesthesia, including the SBP, diastolic blood pressure DBP, MAP and (HR). The second outcome was the comparison of the vasopressor used during the surgery.Results:We established three models to compare the two anesthesia methods on hemodynamic changes.All three models exhibit that changes of MAP (∆MAP) after CSEA were higher than that after CLPSB(β= 6.88, 95% CI: 4.33 - 9.42, P < 0.0001), with significant difference, which indicated that CSEA causes higher fluctuation of MAP. Concurrently, the use of vasopressors increased by 137% (OR=2.37, 95%CI: 1.24-4.53, P=0.0091) in the CSEA group, which is statistically significant. However, the changes of HR (∆HR) between the CLPSB and CSEA was not significant(β= 0.50, 95% CI: 1.62 - 2.62, P = 0.6427). Conclusions:Both CLPSB and CSEA are ideal anesthesia methods for patients receiving femoral head eplacement, though CLPSB is more suitable for elderly patients with advanced hemodynamic stability.
Partial Wave Direct Method Solution to Phase Problem
Authors: Pullooru Bhanumoorthy 
Published: March 2022

Abstract
We cast crystal diffraction as a boundary value problem with Maxwell-Schr\"odinger equation as the governing partial differential equation.Unitcell defined boundary conditions determine definite momentum eigen series in spherical basis to include precision angles as additional data measurable in a stationary spherical polar polar coordinate system with polar axis always aligned along direct beam in the experiment.Orbital structure of individual atoms is contained in angle dependence and thus in the precision angles of position and momentum vectors.Partial wave version of Parseval relation becomes probability conservation law.We show that polar angles and azimuthal angles respectively determine signs and phases of partial wave sub-amplitudes and give rise to solution to phase problem.
The Association Between DNA Methylation of 6p21.33 and AHRR in Blood and Coronary Heart Disease in Chinese Population
Authors: Zhu Liya , Zhu Chao , Wang Jinxin , Yang Rongxi , Zhao Xiaojing 
Published: March 2022

Abstract
Background: Early detection could significantly improve the prognosis of coronary heart disease (CHD). In-invitro diagnostic technique may provide a solution when sufficient biomarkers could be identified. Pertinent associations between blood-based aberrant DNA methylation and smoking, the pathogenesis of atherosclerosis, and CHD have been robustly demonstrated and replicated, but that studies in Chinese populations are rare. The blood-based methylation of aryl-hydrocarbon receptor repressor (AHRR) cg05575921 and 6p21.33 cg06126421 has been associated with cardiovascular mortality in Caucasians. Here, we aim to investigate whether the AHRR and 6p21.33 methylation in the blood is associated with CHD in the Chinese population.Methods: In this case-control study,180 CHD patients and 184 controls were enrolled. Methylation intensities of 19 CpG sites, including AHRR cg05575921, 6p21.33 cg06126421, and their flanking CpG sites, were quantified by mass spectrometry. The association between methylation intensities and CHD was estimated by logistic regression analyses adjusted for covariant.Results: Compared to the controls, lower methylation of 6p21.33_CpG_4.5/cg06126421 was independently associated with increased odds of CHD patients with heart failure and early cardiac dysfunction (OR per -10% methylation = 1.59 and 1.65; p = 0.012 and 0.020 by multiple testing corrections, respectively). No association between blood-based AHRR methylation and CHD was found.Conclusions: 6p21.33 methylation exhibits a significant association with CHD. The combination of 6p21.33 methylation and conventional risk factors might be an intermediate step towards the early detection of CHD.
Managing Diabetes Using Mobiab: Long-Term Case Study of the Impact of a Mobile App on Self-management
Authors: Burda Václav , Mráz Miloš , Schneider Jakub , Novák Daniel 
Published: March 2022

Background
This paper describes the development of a mobile app for diabetes mellitus (DM) control and self-management and presents the results of long-term usage of this system in the Czech Republic. DM is a chronic disease affecting large numbers of people worldwide, and this number is continuously increasing. There is massive potential to increase adherence to self-management of DM with the use of smartphones and digital therapeutics interventions.

Objective
This study aims to describe the process of development of a mobile app, called Mobiab, for DM management and to investigate how individual features are used and how the whole system benefits its long-term users. Using at least 1 year of daily records from users, we analyzed the impact of the app on self-management of DM.

Methods
We have developed a mobile app that serves as an alternative form to the classic paper-based protocol or diary. The development was based on cooperation with both clinicians and people with DM. The app consists of independent individual modules. Therefore, the user has the possibility to use only selected features that they find useful. Mobiab was available free of charge on Google Play Store from mid-2014 until 2019. No targeted recruitment was performed to attract users.

Results
More than 500 users from the Czech Republic downloaded and signed up for the mobile app. Approximately 80% of the users used Mobiab for less than 1 week. The rest of the users used it for a longer time and 8 of the users produced data that were suitable for long-term analysis. Additionally, one of the 8 users provided their medical records, which were compared with the gathered data, and the improvements in their glucose levels and overall metabolic stability were consistent with the way in which the mobile app was used.

Conclusions
The results of this study showed that the usability of a DM-centered self-management smartphone mobile app and server-based systems could be satisfactory and promising. Nonetheless, some better ways of motivating people with diabetes toward participation in self-management are needed. Further studies involving a larger number of participants are warranted to assess the effect on long-term diabetes management.
COMBINATION EFFECT OF LULICONAZOLE AND CLOBETASOL FOR TREATMENT OF SKIN AILMENTS
Authors: PRASHAR DEEPAK , KUMAR VIVEK , JASRA KHUSHBOO 
Published: March 2022

Objective: The new combination for Luliconazole and Clobetasol Propionate was approved for the treatment of a variety of skin disease. The main objective of this research is development and validation of novel, simple, fast and responsive derivative spectroscopic process for simultaneous estimation of newly approved combination Luliconazole (LLZ) and Clobetasol Propionate (CLP).
Methods: Here in this first derivative spectroscopic method, the absorbance of LLZ and CLP was taken at 312 nm (ZCP of CLP) and 249 nm (ZCP of LLZ), respectively. Establishment of linearity was in a concentration varies from 10-50 µg/ml for Luliconazole and 5-25µg/ml for Clobetasole Propionate.
Results: From the method developed above the R2 value observed for LLZ and CLP is 0.9961. Statistical validation of accuracy and reproducibility was done for planned procedure with the help of recovery studies. The mean % recovery of Luliconazole and Clobetasol Propionate was found to be 99.45 % and 99.43%, respectively. For LLZ the Limit of detection is 0.9988 µg/ml and limit of quantification is 0.0009µg/ml and for CLP the Limit of detection is0.0164µg/ml and limit of quantification 0.0027µg/ml.
Conclusion: From research work the method development was done and shows fast, precise, exact and easy accessible laboratory procedure for routine evaluation of combination drugs.
The spread of fire from an open car park on the ground floor of a residential building
Authors: Khasanov I. R. , Zuev S. A. , Abashkin A. A. , Zuevа A. S. 
Published: March 2022

Introduction. The problem of car parks and parking spaces is relevant in many large cities, and it requiresthe optimization of parking spaces. The arrangement of open car parks on the ground floors of apartment buil­dings is an effective way to organize car parks in a house in addition to covered parking lots. In this regard, in order to assess the fire hazard of such a design solution, it is necessary to study the spreadability of fire from an open ground floor parking lot to upper floors and develop reasonable proposals for the development of new and optimization of effective fire safety requirements.Goals and objectives. The goal of this work is to study the spread of fire hazards using the field modeling of the car burning process in an open parking lot on the ground floor of an apartment building and to assess the possibility of the fire safe arrangement of such parking lots in residential buildings.Method. To achieve the purpose of the study, the field (CFD) modeling of the fire development pattern was performed using FDS computer software. In the course of modeling, the authors analyzed the spread of the fire hazard from an open parking lot, located on the ground floor, to the upper floors of a residential building.Results and discussion. Temperature distributions, smoke and heat flows at various points in time were obtained as a result of modeling the development of fire in a parking lot. The results of calculations allowed to evaluate the effectiveness of various types of fire barriers and determine their parameters to meet the condition of the non-proliferation of fire. The most optimal solution is a non-combustible visor made of fire-resistant materials and installed above the opening leading to a parking lot. Given the results of the work, a set of necessary fire-figh­ting actions are proposed to ensure the possibility of arranging open parking lots in residential apartment buildings.Conclusions. It is shown that the fire safety of residential apartment buildings that have open single-level parking lots is achievable in case of the use of fire-resistant bearing and enclosing building structures, non-combustible materials for cladding, finishing the facade of a building, as well as in the case of making a canopy, a balcony or a gallery above the opening that leads to the parking lot.
TINJAUAN FIQH MUAMALAH TERHADAP PRAKTIK TABUNGAN SELASANAN (Studi Kasus Di Desa Bekonang, Kecamatan Mojolaban)
Authors: Kuswandari Nandia Arna 
Published: March 2022

Penelitian ini berangkat dari fenomena praktik tabungan Selasanan dimana anggota menabung setiap hari selasa, kemudian tabungan tersebut dikelola oleh pengurus untuk dipinjamkan kepada anggota maupun luar anggota dengan penambahan manfaat sebesar 3% setiap bulan. Penulis tertarik untuk meneliti tabungan ini dengan tinjauan Islam, karena menurut wawancara dengan pengurus semua anggota dalam tabungan ini adalah beragama Islam. Mereka menabung untuk pemenuhan hari raya. Sebagaimana yang kita ketahui, sebagai umat beragama Islam harus bermuamalah sesuai dengan syariat Islam. Dari uraian di atas maka masalah yang dapat dirumusan dalam skripsi ini adalah bagaimana praktik tabungan Selasanan di Desa Bekonang, Kecamatan Mojolaban dan bagaimana praktik tabungan Selasanan ditinjau dari Fiqh muamalah.Penelitian ini termasuk jenis penelitian lapangan (field research) dengan pendekatan kualitatif tentang Fiqih Muamalah dan praktik tabungan selasanan. Sumbernya didapat dari data primer dan sekunder. Teknik pengumpulan data dengan wawancara, dokumentasi kemudian dianalisis dengan teks yang bersifat narasi lalu ditarik kesimpulan.Praktik tabungan Selasanan ini konsepnya seperti akad mudharabah, namun untuk prosentase bagi hasil tidak jelas. Hal ini menyebabkan akad ini menjadi fasidÂ dalam praktiknya, pinjaman yang ada di tabungan Selasanan Desa Bekonang masih terdapat penambahan manfaat sebesar 3% setiap bulan. Hasil penelitian menunjukkan bahwa tambahan manfaat sebesar 3% bukan termasuk riba, namun penambahan 3%Â setiap bulan tersebut untuk anggota sebagai pemilik dana dan sebagai ujrah bagi pengurus karena telah mengelola dana tabungan ini.
PERBANDINGAN TINGKAT AKURASI HASIL PERHITUNGAN AWAL WAKTU SALAT MENGGUNAKAN JAM DIGITAL DAN EPHEMERIS 2021
Authors: Ahyani Nurul 
Published: March 2022

Abstrak Urgensi problematika penentuan awal waktu salat sangatlah menarik untuk dilakukan penelitian lebih jauh. Kemudian untuk menjadikan penelitian ini agar bisa terfokus maka, penelitian ini difokuskan pada metode dan akurasinya. Adapun lokasi penelitian yaitu dengan obyek masjid yang ada di Desa Pucangmiliran, Kecamatan Tulung, Kabupaten Klaten. Penelitian ini untuk mengetahui kondisi yang sebenarnya di lokasi penelitian. Sehingga dari data tersebut akan dikontekstualisasikan sesuai dengan awal waktu salat dengan metode perhitungan yang dalam ephemeris 2021. Penelitian ini termasuk penelitian lapangan karena dalam penelitian ini peneliti mencoba membuktikan data yang ada di lapangan. Penelitian ini menggambarkan tentang kondisi jam digital di Masjid Desa Pucangmiliran, serta menggambarkan sifat dan karakter dari objek yang diteliti dan keakuratanya. Penelitian ini menghasilkan 2 temuan: Pertama, konsep hisab awal waktu salat dalam Ephemeris Hisab Rukyat 2021 yang bersumber dari buku karya Muhyidin Khazin dalam buku Ilmu Falak dalam Teori dan Praktik, yang didalamnya menjelaskan mengenai ketentuan Deklinasi Matahari yaitu untuk tinggi Matahari saat Maghrib = - 1o , Isya = 18o , Subuh = -20o , Kedua, hasil uji akurasi hisab waktu salat hasil hisab awal waktu salat dengan menggunakan Jam Digital terlalu cepat pada waktu salat Asar jika dibandingkan dengan hisab rukyat dalam metode Ephemeris 2021. Kemudian hasil Â hisab awal waktu salat dengan menggunakan Jam Digital dan metode Ephemeris memiliki selisih yang tidak jauh.
Reporte de caso de neoplasia biliar metastásica como causa inusual de apendicitis
Authors: Peña Amaya Rafael Gregorio , Montaña López Jaime Andrés , Sánchez Marrugo Carolina Isabel , Pérez Navarro Luis Carlos 
Published: March 2022

Introducción: se describe el caso de una paciente con una metástasis apendicular como primera manifestación encontrada de un colangiocarcinoma. Síntomas principales: expresado con dolor abdominal, ictericia, hiporexia y coluria.
Métodos y resultados: se documentó un plastrón apendicular histológicamente compatible con adenocarcinoma apendicular metastásico, estrechez del conducto hepático común, con alta sospecha de colangiocarcinoma, corroborado luego con la realización de una colangiopancreatografía retrógrada endoscópica.
Conclusiones: los tumores apendiculares metastásicos son una presentación infrecuente y poco estudiada, donde los secundarios a neoplasia de vía biliar se han reportados de forma muy escasa en la literatura.