bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accurately quantifying the superposition state of two different Laguerre–Gaussian modes with single intensity distribution measurement
Authors: Xiao Ya , Liu Haida , Song Yuewei , HanZhao Qizhi , Che Fengheng , Fan Xuan , Han Xinhong , Qu Huichao , Li Weichen , Li Wendong , Gu Yongjian 
Published: February 2022

AbstractWe develop a method to quantify the superposition state of two different Laguerre–Gaussian modes. By analyzing the characteristics of the intensity distribution obtained in a single measurement, including the petal number, the position and value of the extremum intensity, one can quantify the angular momentum index, the radial node index and the superposition coefficient simultaneously. Experimentally, we measure a series of superposition states, whose angular momentum index ranges from −47 to 53, radial node index from 0 to 3 and superposition weight from 0.1 to 0.9. The average trace distance and the mean fidelity of these states are lower than 0.053 ± 0.001 and higher than 0.982 ± 0.002, respectively. Our method can further obtain the superposition coefficient compared with previous mode verification ones and can reduce the number of measurement settings compared with the traditional quantum state tomography, thus more applicable in practice.
Elevated level of lysophosphatidic acid among patients with HNF1B mutations and its role in RCAD syndrome: a multiomic study
Authors: Małachowska Beata , Janikiewicz Justyna , Pietrowska Karolina , Wyka Krystyna , Madzio Joanna , Wypyszczak Kamila , Tkaczyk Marcin , Chrul Sławomir , Zwiech Rafał , Hogendorf Anna , Małecki Maciej T. , Borowiec Maciej , Krętowski Adam , Młynarski Wojciech , Dobrzyń Agnieszka , Ciborowski Michał , Fendler Wojciech 
Published: February 2022

Abstract
Introduction
Patients with hepatocyte nuclear factor-1 beta (HNF1B) mutations present a variable phenotype with two main symptoms: maturity onset diabetes of the young (MODY) and polycystic kidney disease (PKD).

Objectives
Identification of serum metabolites specific for HNF1Bmut and evaluation of their role in disease pathogenesis.

Methods
We recruited patients with HNF1Bmut (N = 10), HNF1Amut (N = 10), PKD: non-dialyzed and dialyzed (N = 8 and N = 13); and healthy controls (N = 12). Serum fingerprinting was performed by LC-QTOF-MS. Selected metabolite was validated by ELISA (enzyme-linked immunosorbent assay) measurements and then biologically connected with HNF1B by in silico analysis. HepG2 were stimulated with lysophosphatidic acid (LPA) and HNF1B gene was knocked down (kd) by small interfering RNA. Transcriptomic analysis with microarrays and western blot measurements were performed.

Results
Serum levels of six metabolites including: arachidonic acid, hydroxyeicosatetraenoic acid, linoleamide and three LPA (18:1, 18:2 and 20:4), had AUC (the area under the curve) > 0.9 (HNF1Bmut vs comparative groups). The increased level of LPA was confirmed by ELISA measurements. In HepG2HNF1Bkd cells LPA stimulation lead to downregulation of many pathways associated with cell cycle, lipid metabolism, and upregulation of steroid hormone metabolism and Wnt signaling. Also, increased intracellular protein level of autotaxin was detected in the cells. GSK-3alpha/beta protein level and its phosphorylated ratio were differentially affected by LPA stimulation in HNF1Bkd and control cells.

Conclusions
LPA is elevated in sera of patients with HNF1Bmut. LPA contributes to the pathogenesis of HNF1B-MODY by affecting Wnt/GSK-3 signaling.
Environmental Kuznets curve for CO2 emissions in Baltic countries: an empirical investigation
Authors: Kar Ashim Kumar 
Published: February 2022

AbstractRecognizing the factors responsible for the gradual increase in greenhouse gas [e.g. carbon dioxide (CO2)] emissions is crucial to reduce the detrimental consequences on environmental sustainability and human life. Accordingly, spotting the sectors which contribute the most to CO2 emissions and dampen economic growth have become one of the major concerns for policymakers around the globe. Against this background, this paper examines the nexus between economic growth and CO2 emissions in three Baltic countries namely Estonia, Latvia and Lithuania. Thus, the study basically checks the validity of the environmental Kuznets curve (EKC) hypothesis by taking into account the role of energy consumption and financial development over the period of 1990–2018. This type of study is highly important for the region in order to comply with the commitments of the Paris Agreement and Sustainable Development Goals of the United Nations. The study first employs appropriate testing procedures and second-generation panel data methods to account for cross-sectional dependency and slope heterogeneity among countries. Applying unit roots and cointegration tests, the study then employed different mean group estimation models and heterogeneous panel causality methods suitable for cross-sectionally dependent and heterogeneous panels. The results of the econometric analyses reveal that the inverted U-shaped EKC hypothesis does not hold in the Baltic countries. But the pollution haven hypothesis is evidenced to hold for these nations. By boosting the CO2 emissions figures, again, the study also revealed that higher levels of energy consumption exhibit adverse environmental consequences. Financial development is found to be effective in explaining the variations in the CO2 emission figures of the selected countries as well. Causality test results confirm bi-directional causality between economic growth and CO2 emissions, energy use and CO2 emissions, CO2 emissions and financial development, energy use and economic growth as well as between energy use and financial development. Furthermore, country-specific impacts are found to be similar to the corresponding panel estimates. Consistent with the findings, the study finally puts forward some policy-level suggestions. Accordingly, it is recommended that the Baltic countries need to move away from fossil-fuel dependent energy consumption growth policies to mitigate environmental degradation.
Comparative environmental and social life cycle assessments of off-shore aquaculture rafts made in ultra-high performance concrete (UHPC)
Authors: Caruso Maria Chiara , Pascale Carmine , Camacho Esteban , Ferrara Liberato 
Published: February 2022

Abstract
Purpose
This paper aims to compare the environmental and social impacts of three types of rafts for mussel farming in Spain. These structures, traditionally made of wood, have a short lifespan and, because of their service conditions, require frequent maintenance in order to be fully operational. An innovative solution made with ultra-high performance concrete (UHPC) was developed in 2016 by RDC, being at the base of the pilots of the EU-funded project ReSHEALience (H2020-GA760824).

Methods
In order to quantify the environmental and social impacts generated by alternative solutions for the aquaculture raft, a life cycle approach has been used. The life cycle assessment methodology, according to ISO 14040 and ISO 14044 standards, has been used for the evaluation of the environmental impacts, while the social life cycle assessment (SLCA) methodology, according to the Guidelines for SLCA of Products and the social impact assessment method developed by Ciroth and Franze (2011), has been used for the evaluation of the social impacts: the same functional unit and the same stages of the life cycle to be included in the study has been set for the alternative solutions.

Results and discussion
Based on the LCA results, derived from the system boundary described in the “Goal and scope” section for the mussel aquaculture structures, the highest environmental impacts in the cradle-to-grave analysis are generated by the Traditional Raft with maintenance based on the periodic application of paints; the lowest environmental impacts are generated by the Traditional Raft with maintenance based on the progressive replacement of the damaged logs, while the Innovative Raft has an intermediate behavior in terms of environmental impact generation. Based on the S-LCA results, it can be stated that both the solutions generate high impacts; nevertheless, the Innovative solution has a slight lower impact than the Traditional solutions, which could be lowered if some precautions in the society policy are taken. Social hot-spots are identified in order to help reducing the overall social impacts.

Conclusions
In conclusion, it can be stated that, from both the environmental and social points of view, the Traditional Solutions for the aquaculture raft are the most “impactful,” especially when the maintenance is based on paint application. The use of innovative concretes allows to build longer lifespan rafts with minimum (or no) need of maintenance. Moreover, the behavior of new companies is more attentive to social aspects related to their activities and has a margin of improvement, when compared to traditional companies.
Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients
Authors: Kondo Taishi , Ishida Tomoaki , Ye Ke , Muraguchi Marin , Tanimura Yohei , Yoshida Masato , Ishiuchi Kan’ichiro , Abe Tomoki , Nikawa Takeshi , Hagihara Keisuke , Hayashi Hidetoshi , Makino Toshiaki 
Published: February 2022

AbstractProcessed aconite root (PA), the tuberous root of Aconitum carmichaelii prepared by autoclaving, is a crude drug used in Japanese traditional Kampo medicine and traditional Chinese medicine for the symptoms of kidney deficiency, that is related to the muscle atrophy in modern medicine. The objective of the present study is to evaluate the effectiveness of PA on muscle atrophy and to find its active ingredients using dexamethasone-induced muscle ring finger protein-1 (MuRF1) mRNA expression in murine myoblast C2C12 cells. Dexamethasone-induced MuRF1 expression was significantly suppressed by methanol-soluble part of boiling water extract of PA in a concentration-dependent manner with its IC50 value of 1.5 mg/ml. By the activity-guided fractionations of PA extract using the partition between organic solvents and its aqueous solution, the activity of PA did not transfer into the fraction containing aconitine-type diterpenoid alkaloids but into BuOH layer. Then, we found higenamine and salsolinol as the active ingredients in PA. Higenamine and salsolinol significantly suppressed dexamethasone-induced MuRF1 expression, and their IC50 values were 0.49 and 50 µM, respectively. The contents of higenamine and salsolinol in the decoctions of commercially available fourteen PA products are 0.12 and 14 µg/ml as the average values, and varied with the coefficient of variation (CV) values of 97 and 63%, respectively. Higenamine also significantly suppressed dexamethasone-induced mRNA expressions of muscle atrophy F-box protein (MAFbx)/atrogin1, casitas B-lineage lymphoma-b (Cbl-b), troponin, branched-chain amino acid aminotransferase 2 (BCAT2), and Bcl-2 binding and pro-apoptotic protein3 (Bnip3). Although the quality control of PA is regulated by the contents of diterpene alkaloids, salsolinol and higenamine can be used as the marker compounds to certificate the pharmacological activities of PA.
Graphical abstract
Der Capability-Ansatz in der Bewegungsförderung
Authors: Till Maike , Abu-Omar Karim , Gelius Peter 
Published: February 2022

Zusammenfassung
Hintergrund
Die Befähigung verschiedener Zielgruppen und der Abbau gesundheitlicher Ungleichheit stehen bei Projekten der Bewegungsförderung häufig im Fokus. Die dabei oft als theoretische Basis eingesetzten Determinanten- und Empowerment-Ansätze weisen in der konkreten Projektarbeit jedoch Nachteile auf. Als Alternative hat in den letzten Jahren der Capability-Ansatz (CA) eine zunehmende Verbreitung gefunden. Bisher haben allerdings nur wenige Arbeiten untersucht, welche Vorzüge dieser Ansatz hat und wie er sich in Projekten der Gesundheitsförderung einsetzen lässt.

Ziel
Dieser Beitrag soll aufzeigen, wie der CA für die Evaluation bereits abgeschlossener Interventionen der Bewegungsförderung nutzbar gemacht werden kann, Wirkungen in verschiedenen Bereichen sichtbar macht und sie in Beziehung zueinander setzt.

Methodik und Material
Mithilfe des CA wurde die Arbeit des Projekts exemplarisch evaluiert. Dafür wurden über einen Zeitraum von 16 Jahren entstandene Projektpublikationen (n = 37) einer systematischen Dokumentenanalyse unterzogen.

Ergebnis
Die Einordnung des Projekts in ein Capability-Modell illustriert das breite Spektrum von Ergebnissen einer partizipativen Intervention zur Bewegungsförderung auf verschiedenen Ebenen. Der Ansatz ermöglicht es zudem, die Verbindungen von Verhaltens- und Verhältnisebene sowie zwischen der „Zielgruppe“ und Multiplikator:innen im Setting zu veranschaulichen.

Schlussfolgerung
Der CA ermöglicht Projekten der Bewegungsförderung eine systematische Betrachtung von Wirkungen auf Verhaltens- und Verhältnisebene, und nimmt neben dem Individuum auch das Kollektiv in den Blick. Er bietet somit die Chance, Empowerment- und Determinantenansätze der Ungleichheitsforschung systematisch zu verbinden und für die Projektevaluation nutzbar zu machen.
Disassociated and concurrent structural and functional abnormalities in the drug-naïve first-episode early onset schizophrenia
Authors: Li Qiang , Liu Sha , Cao Xiaohua , Li Zexuan , Fan Yun-shuang , Wang Yanfang , Wang Jiaojian , Xu Yong 
Published: February 2022

AbstractSchizophrenia which is an abnormally developmental disease has been widely reported to show abnormal brain structure and function. Enhanced functional integration is a predominant neural marker for brain mature. Abnormal development of structure and functional integration may be a biomarker for early diagnosis of schizophrenia. Fifty-five patients with early onset schizophrenia (EOS) and 79 healthy controls were enrolled in this study. Voxel-based morphometry (VBM) and functional connectivity density (FCD) were performed to explore gray matter volume (GMV) lesion, abnormal functional integration, and concurrent structural and functional abnormalities in the brain. Furthermore, the relationships between abnormalities structural and function and clinical characteristics were evaluated in EOS. Compared with healthy controls, EOS showed significantly decreased GMV in the bilateral OFC, frontal, temporal, occipital, parietal and limbic system. EOS also showed decreased FCD in precuneus and increased FCD in cerebellum. Moreover, we found concurrent changes of structure and function in left lateral orbitofrontal cortex (lOFC). Finally, correlation analyses did not find significant correlation between abnormal neural measurements and clinical characteristic in EOS. The results reveal disassociated and bound structural and functional abnormalities patterns in EOS suggesting structural and functional measurements play different roles in delineating the abnormal patterns of EOS. The concurrent structural and functional changes in lOFC may be a biomarker for early diagnosis of schizophrenia. Our findings will deepen our understanding of the pathophysiological mechanisms in EOS.
Exogenous H2S Ameliorates High Salt-Induced Hypertension by Alleviating Oxidative Stress and Inflammation in the Paraventricular Nucleus in Dahl S Rats
Authors: Liao Yingying , Fan Yuanyuan , He Qinglin , Li Yuwei , Wu Dongdong , Jiang Enshe 
Published: February 2022

AbstractHydrogen sulfide (H2S) is an important gaseous signaling molecule that regulates cardiovascular activity in animals. The hypothalamic paraventricular nucleus (PVN) is a major integrative region involved in blood pressure (BP) regulation. We explored whether exogenous H2S application by intraperitoneal injection of sodium hydrosulfide (NaHS) alleviates BP increase induced by a high salt diet (HSD) and the role of PVN in Dahl salt-sensitive (Dahl S) rats. Dahl S rats were divided into four groups according to diet regime (normal salt diet [NSD] and HSD) and treatment method (daily intraperitoneal NaHS or saline injection). We monitored BP, food and water intake, and body weight for 8 weeks. Plasma, kidney, and brain tissues were collected at the end of the experiment. We found that exogenous H2S not only delayed BP elevation but also attenuated the increase in the levels of norepinephrine, cystatin C, and blood urea nitrogen in the plasma of Dahl S rats with an HSD. Furthermore, H2S enhanced the total antioxidant capacity, superoxide dismutase, and glutathione peroxidase in the PVN. Exogenous H2S attenuated the protein expression of the nuclear factor-κB pathway and proinflammatory cytokines, which were significantly higher in the PVN in rats with an HSD than in rats with an NSD. Additionally, exogenous H2S relieved PVN neuronal apoptosis induced by an HSD. These findings suggest that exogenous H2S attenuates hypertension caused by an HSD by ameliorating oxidative stress, inflammation, and apoptosis in the PVN. This study provides evidence of the benefits of peripheral H2S therapy for hypertension.
Biogas Potential of Agriculture
Authors: Nurgaliev Timur , Müller Joachim , Koshelev Valery 
Published: February 2022

AbstractThe purpose of this research is to evaluate the biogas potential of agriculture in the typical Russian region. The design of this study was completed using the main kinds of agricultural production of the Tambov region as the feedstocks for biogas production. Average amounts of the feedstocks were calculated on the base of data for the period 2009–2018. The quantities and revenues of electricity, heat, and biofertilizers from biogas produced from various substrates were estimated and mapped for each of the twenty-three municipal districts of the region. Results revealed an average total monetary biogas potential of 88.52 × 109 RUB for the Tambov region per year, where 75.43% are provided by electricity and heat energy and the remaining 24.57%—by biofertilizers, therefore, biogas potential of the Tambov region is comparable with biogas potential of a European country. Such feedstocks as sunflower silage, cereal grain, and cereal straw were defined as the most attractive substrates in the region. At the same time, the most of feedstocks being the main farmers’ commodity production are debatable to be used as substrates; as for Russian farmers, biogas production is a new and not well-known technology. Nevertheless, the developed calculation method can now be applied by local authorities of the Tambov region and other regions of the Russian Federation as the base to develop the biogas sector in the most promising areas by supporting farmers and business structures and attracting investments in biogas technology.
Outcome analysis of primary breast cancer patients who declined adjuvant chemotherapy—results from the prospective multi-center BRENDA II study
Authors: Leinert Elena , Schwentner Lukas , Janni Wolfgang , Wöckel Achim , Herbert Saskia-L. , Herr Daniel , Kühn Thorsten , Flock Felix , Felberbaum Ricardo , Kreienberg Rolf , Fink Visnja , Dayan Davut , Ernst Kristina , Singer Susanne ,   the BRENDA study group
Published: February 2022

AbstractBackgroundThis study examined 5-year overall, recurrence and distant metastasis-free survival (OS, RFS, MFS) of high- and intermediate-risk breast cancer (BC) patients who declined guideline-recommended adjuvant chemotherapy (CHT).MethodsIn the prospective multicenter cohort study BRENDA II, patients with primary BC were sampled over a period of four years (2009–2012). A multi-professional team (tumorboard) discussed recommendation for adjuvant CHT according to the German guideline. Potential differences in 5 year survival were analyzed using Kaplan–Meier curves and Cox regression. The hazard ratios (HR) were adjusted for age, Charlson Comorbidity Score, American Society of Anesthesiologist (ASA) physical status classification, and endocrine therapy.ResultsA total of 759 patients were enrolled of which 688 could receive CHT according to the guidelines (n = 219 had a clear indication, inn = 304 it was possible). For 360 patients, the tumorboard advised to perform CHT, for 304 it advised against and in 24 cases, no decision was documented. Of those with a positive suggestion, 83% received CHT. Until 5 years after diagnosis, 57 patients were deceased, 41 had at least one distant metastasis and 29 a recurrence. There was no evidence for differences in OS and MFS in patients who declined CHT despite tumorboard recommendation (HR 3.5, 95% CI 0.8–15.1 for OS, HR 1.9, 95% 0.6–6.6 for MFS). Patients who received CHT had significantly better 5-year RFS compared to those who declined (HR 0.3, 95% CI 0.1–0.9,p = 0.03). There was no evidence for different survival in those who had no CHT because of comorbidity and those who declined actively, neither for OS, MFS nor RFS.ConclusionThe prospective BRENDA II study demonstrates benefit in RFS by guideline adherence in adjuvant breast cancer treatment, indicating prospectively the value of internationally validated guidelines in breast cancer care.
Refining the Bayesian Approach to Unifying Generalisation
Authors: Poth Nina 
Published: February 2022

AbstractTenenbaum and Griffiths (Behavioral and Brain Sciences 24(4):629–640, 2001) have proposed that their Bayesian model of generalisation unifies Shepard’s (Science 237(4820): 1317–1323, 1987) and Tversky’s (Psychological Review 84(4): 327–352, 1977) similarity-based explanations of two distinct patterns of generalisation behaviours by reconciling them under a single coherent task analysis. I argue that this proposal needs refinement: instead of unifying the heterogeneous notion of psychological similarity, the Bayesian approach unifies generalisation by rendering the distinct patterns of behaviours informationally relevant. I suggest that generalisation as a Bayesian inference should be seen as a complement to, instead of a replacement of, similarity-based explanations. Furthermore, I show that the unificatory powers of the Bayesian model of generalisation can contribute to the selection of one of these models of psychological similarity.
Textile wastewater heavy metal removal using Luffa cylindrica activated carbon: an ANN and ANFIS predictive model evaluation
Authors: Nwosu-Obieogu Kenechi , Dzarma Goziya W. , Ehimogue Precious , Ugwuodo Chijioke B. , Chiemenem Linus I. 
Published: February 2022

AbstractThis study investigated the application of soft computing models [Artificial neural network (ANN) and Adaptive neuro-fuzzy inference system (ANFIS)] in removing heavy metals [chromium (VI), vanadium (V) and iron (II)] from textile wastewater using Luffacylindrica activated carbon (LAC). The effect of pH, contact time and adsorbent dosage on the adsorptive potential of the prepared LAC were determined using a batch mode experiment. Fourier Transform Infrared Spectroscopy and scanning electron micrograph assessed the potential of the adsorbent in this study. ANN and ANFIS were evaluated using the coefficient of determination (R2) and mean square error (MSE). The result showed that the models demonstrated significant predictive behavior with R2 (9.9999E−1), MSE (5.985E−14) for chromium(VI) removal, R2 (9.9999E−1), MSE (2.33856E−13) for iron(II) removal and R2 (9.9999E−1), MSE (7.22197E−12) for vanadium(V) removal for ANN, while ANFIS predicted R2 (0.76305), MSE (0.037105) for chromium(VI) removal, R2 (0.67652), MSE (0.846) for iron(II) removal, R2 (0.22673), MSE (0.65925) for vanadium(V) removal. Sensitivity analysis carried out with ANFIS (exhaustive search) indicated that the parameters (time, pH and adsorbent dosage) significantly impact the heavy metal removal. Thus, this study shows that ANN and ANFIS are reliable tools for modelling heavy metal removal using LAC. The parameter results obtained are relevant in process design and control.