bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti‐CD19 and anti‐BCMA CAR T cell therapy followed by lenalidomide maintenance after autologous stem‐cell transplantation for high‐risk newly diagnosed multiple myeloma
Authors: Shi Xiaolan , Yan Lingzhi , Shang Jingjing , Kang Liqing , Yan Zhi , Jin Song , Zhu Mingqing , Chang Huirong , Gong Feiran , Zhou Jiazi , Chen Guanghua , Pan Jinlan , Liu Dandan , Zhu Xiaming , Tang Fang , Liu Minghong , Liu Wei , Yao Feirong , Yu Lei , Wu Depei , Fu Chengcheng 
Published: February 2022

AbstractFew prospective studies have examined posttransplant chimeric antigen receptor (CAR) T cell infusion as candidates for front‐line consolidation therapy for high‐risk multiple myeloma (MM) patients. This single‐arm exploratory clinical trial is the first to evaluate the safety and efficacy of sequential anti‐CD19 and anti‐BCMA CAR‐T cell infusion, followed by lenalidomide maintenance after autologous stem cell transplantation (ASCT), in 10 high‐risk newly diagnosed multiple myeloma (NDMM) patients. The treatment was generally well tolerated, with hematologic toxicities being the most common grade 3 or higher adverse events. All patients had cytokine release syndrome (CRS), which was grade 1 in 5 patients (50%) and grade 2 in 5 patients (50%). No neurotoxicity was observed after CAR‐T cell infusion. The overall response rate was 100%, with the best response being 90% for a stringent complete response (sCR), and 10% for a complete response (CR). At a median follow‐up of 42 (36–49) months, seven (70%) of 10 patients showed sustained minimal residual disease (MRD) negativity for more than 2 years. The median progression‐free survival (PFS) and overall survival (OS) were not reached. Although the sample size was small and there was a lack of control in this single‐arm study, the clinical benefits observed warrant ongoing randomized controlled trials.
OFD1: One gene, several disorders
Authors: Pezzella Nunziana , Bove Guglielmo , Tammaro Roberta , Franco Brunella 
Published: February 2022

AbstractThe OFD1 protein is necessary for the formation of primary cilia and left–right asymmetry establishment but additional functions have also been ascribed to this multitask protein. When mutated, this protein results in a variety of phenotypes ranging from multiorgan involvement, such as OFD type I (OFDI) and Joubert syndromes (JBS10), and Primary ciliary dyskinesia (PCD), to the engagement of single tissues such as in the case of retinitis pigmentosa (RP23). The inheritance pattern of these condition differs from X‐linked dominant male‐lethal (OFDI) to X‐linked recessive (JBS10, PCD, and RP23). Distinctive biological peculiarities of the protein, which can contribute to explain the extreme clinical variability and the genetic mechanisms underlying the different disorders are discussed. The extensive spectrum of clinical manifestations observed inOFD1‐mutated patients represents a paradigmatic example of the complexity of genetic diseases. The elucidation of the mechanisms underlying this complexity will expand our comprehension of inherited disorders and will improve the clinical management of patients.
C‐reactive protein levels and risk of dementia—Observational and genetic studies of 111,242 individuals from the general population
Authors: Hegazy Sharif H. , Thomassen Jesper Qvist , Rasmussen Ida Juul , Nordestgaard Børge G. , Tybjærg‐Hansen Anne , Frikke‐Schmidt Ruth 
Published: February 2022

AbstractIntroductionIncreased plasma levels of C‐reactive protein (CRP) in midlife are associated with increased risk of Alzheimer's disease (AD), whereas in older age the opposite association is observed. Whether genetically determined CRP is associated with AD remains unclear.MethodsA total of 111,242 White individuals from the Copenhagen General Population Study and the Copenhagen City Heart Study were included. Plasma levels of CRP and four regulatory genetic variants in the CRP gene were determined.ResultsFor CRP percentile group 1 to 5 (lowest plasma CRP) versus the 50 to 75 group (reference), the hazard ratio for AD was 1.69 (95% confidence interval 1.29–2.16). Genetically low CRP was associated with increased risk of AD in individuals with body mass index ≤25 kg/m2 (P = 4 × 10−6).DiscussionLow plasma levels of CRP at baseline were associated with high risk of AD in individuals from the general population. These observational findings were supported by genetic studies.
Rheological behaviors of plasticized polyvinyl chloride thermally conductive composites with oriented flaky fillers: A case study on graphite and mica
Authors: Zhang Han , Zhang Jun 
Published: February 2022

AbstractIn this study, two oriented flaky fillers in plasticized polyvinyl chloride (P‐PVC) matrix were respectively compared on some rheological behaviors such as dynamic rheological behavior, melt flow rate, and Barus effect. By comparing and analyzing the rheological behaviors and thermal conductivity of P‐PVC/graphite and P‐PVC/mica composites with oriented fillers, it is found that the P‐PVC/graphite composites have obvious percolation thresholds of viscosity, modulus and thermal conductivity at 23.6 vol%. However, P‐PVC/mica composites did not show similar phenomenon. Moreover, the variable parameter K′ in the modified Kerner–Nielson equation was used to relate the rheological behavior, percolation concentration and thermal conductivity of the composites, and the formation of the filler network was analyzed through the rheological behavior to explain the influence of the percolation threshold in the composites caused by the change of internal structure on the thermal conductivity. It has important guiding significance for the mechanism research and comprehensive performance improvement of the filled composites.
An efficient pH‐responsive kappa‐carrageenan/tamarind kernel powder hydrogel for the removal of brilliant green and rose bengal from aqueous solution
Authors: Vaid Vasudha , Jindal Rajeev 
Published: February 2022

AbstractThe objective of this study was to develop an eco‐friendly, cost‐effective, and efficient adsorbent using kappa‐carrageenan (KCG) and tamarind kernel powder (TKP) based cross‐linked 3‐D network hydrogel. The equilibrium swelling capacity of 1429% was achieved by optimization studies. The KCG/TKP hydrogel was characterized by Fourier transform infrared spectroscopy, X‐ray diffraction, field emission scanning electron microscopy, energy dispersive spectroscopy, and thermogravimetric analysis. This hydrogel was employed for the efficient removal of brilliant green (BG) and rose bengal (RB) dye from wastewater. BG and RB were used as a cationic and anionic model dye, respectively. The adsorption capacity of model dyes on KCG/TKP was investigated under different parameters like dye concentration, pH, temperature, and adsorbent amount. With remarkable adsorption capacity, the hydrogel demonstrated a strong dependence on the pH of the medium. The kinetics, adsorption isotherm, thermodynamic studies, and reusability were investigated. The KCG/TKP hydrogel follows pseudo‐second‐order kinetics and the Langmuir isotherm model for the adsorption of both BG and RB model dyes. Spontaneity and exothermic behavior of the adsorption process were revealed by thermodynamic findings. At pH 9, the maximum adsorption capacity of BG was 840.33 mg g−1 while the maximum adsorption capacity of RB was 168.06 mg g−1 at pH 5.
A facile approach to fabricate flexible capacitance sensor based onSpatial Confining Forced Network Assemblymethod for detecting and analyzing large deformation of damping rubber
Authors: Bai Xiaofeng , Fu Hongbo , Liu Ying , Sun Jingyao , Yan Kexin , Gao Xiaolong , Xu Hong , Yang Zhenzhou , Wu Daming , Huang Yao 
Published: February 2022

AbstractEfficiently estimating the aging status of rubber damping is indispensable in the transport system. Herein, we developed a facile approach to fabricate flexible capacitance sensors that can bear high loads, large deformations, and long cycle life. The sensor has a sandwich structure, including electrode layer, the dielectric layer, and encapsulation layer. In this approach, the spatial confining forced network assembly method was used to fabricate the electrode layer of the sensor and a novel injection mold process was used to form the encapsulation layer of the sensor. This flexible capacitive sensor can detect the cyclic loading of damping rubber springs as high as 0‐60 kN under load frequency of 3 Hz with a sensitivity of 30 PF/KN, bear up to maximum 58% deformation and cycling stability over 50,000 cycle. Furthermore, a modified aging status prediction model for damping rubber springs based on the signal of sensor is proposed. The real‐time working state and aging state of the rubber spring can be monitored through the measurement signal of the sensor.
Einführung zum Carbonbeton
Authors: Lieboldt Matthias 
Published: February 2022

AbstractIn den vergangenen zwei Jahrzehnten ist Carbonbeton mit zunehmender Tendenz fester Bestandteil der Forschung geworden und bereits in der Baupraxis angekommen. Durch die steigende Anzahl an allgemeinen bauaufsichtlichen Zulassungen (abZ) und Zustimmungen im Einzelfall (ZiE) verbreitert sich der Anwendungsbereich des Carbonbetons von der Verstärkung und Instandsetzung bis zum Neubau immer weiter. Darauf aufbauend werden die Arbeiten an den ersten technischen Regelwerken intensiv vorangetrieben. Der Beitrag gibt einen kurzen Überblick zur Entstehung, dem Material und dem aktuellen Stand der Nutzung.
Optimal dynamic treatment regime estimation using information extraction from unstructured clinical text
Authors: Zhou Nina , Brook Robert D. , Dinov Ivo D. , Wang Lu 
Published: February 2022

AbstractThe wide‐scale adoption of electronic health records (EHRs) provides extensive information to support precision medicine and personalized health care. In addition to structured EHRs, we leverage free‐text clinical information extraction (IE) techniques to estimate optimal dynamic treatment regimes (DTRs), a sequence of decision rules that dictate how to individualize treatments to patients based on treatment and covariate history. The proposed IE of patient characteristics closely resembles “The clinical Text Analysis and Knowledge Extraction System” and employs named entity recognition, boundary detection, and negation annotation. It also utilizes regular expressions to extract numerical information. Combining the proposed IE with optimal DTR estimation, we extract derived patient characteristics and use tree‐based reinforcement learning (T‐RL) to estimate multistage optimal DTRs. IE significantly improved the estimation in counterfactual outcome models compared to using structured EHR data alone, which often include incomplete data, data entry errors, and other potentially unobserved risk factors. Moreover, including IE in optimal DTR estimation provides larger study cohorts and a broader pool of candidate tailoring variables. We demonstrate the performance of our proposed method via simulations and an application using clinical records to guide blood pressure control treatments among critically ill patients with severe acute hypertension. This joint estimation approach improves the accuracy of identifying the optimal treatment sequence by 14–24% compared to traditional inference without using IE, based on our simulations over various scenarios. In the blood pressure control application, we successfully extracted significant blood pressure predictors that are unobserved or partially missing from structured EHR.
National survey on the current practice and attitudes toward the management of chronic subdural hematoma
Authors: Holl Dana C. , Blaauw Jurre , Ista Erwin , Dirven Clemens M.F. , Kho Kuan H. , Jellema Korné , van der Gaag Niels A. , Miah Ishita P. , den Hertog Heleen M. , van der Naalt Joukje , Jacobs Bram , Verbaan Dagmar , Polinder Suzanne , Lingsma Hester F. , Dammers Ruben ,   Dutch Subdural Hematoma Research group collaboration
Published: February 2022

AbstractBackgroundChronic subdural hematoma (CSDH) is a frequent pathological entity in daily clinical practice. However, evidence‐based CSDH‐guidelines are lacking and level I evidence from randomized clinical trials (RCTs) is limited. In order to establish and subsequently implement a guideline, insight into current clinical practice and attitudes toward CSDH‐treatment is required. The aim is to explore current practice and attitudes toward CSDH‐management in the Netherlands.MethodsA national online survey was distributed among Dutch neurologists and neurosurgeons, examining variation in current CSDH‐management through questions on treatment options, (peri)operative management, willingness to adopt new treatments and by presenting four CSDH‐cases.ResultsOne hundred nineteen full responses were received (8% of neurologists,N = 66 and 35% of neurosurgeons,N = 53). A majority of the respondents had a positive experience with burr‐hole craniostomy (93%) and with a conservative policy (56%). Around a third had a positive experience with the use of dexamethasone as primary (30%) and additional (33.6%) treatment. These numbers were also reflected in the treatment preferences in the presented cases. (Peri)operative management corresponded among responding neurosurgeons. Most respondents would be willing to implement dexamethasone (98%) if equally effective as surgery and tranexamic acid (93%) if effective in CSDH‐management.ConclusionVariation was found regarding preferential CSDH‐treatment. However, this is considered not to be insurmountable when implementing evidence‐based treatments. This baseline inventory on current clinical practice and current attitudes toward CSDH‐treatment is a stepping‐stone in the eventual development and implementation of a national guideline.
Comparison of factors influencing the willingness to donate biospecimens among guardians of children with cancer and adult cancer patients
Authors: Gao Hongxiang , Cao Baige , Dang Nan , Gu Song , Xu Min , Ji Bin , Shi Yiqi , Liu Shijian , Wang Congrong 
Published: February 2022

AbstractBackgroundThis study examined and compared the attitudes and willingness of guardians of children with cancer and adult cancer patients toward donating biospecimens and clinical data for cancer research.MethodsWe conducted a cross‐sectional study among guardians of children with cancer (Guardian group) from Shanghai Children's Medical Center and adult cancer patients (Adult group) from Shanghai Ninth People's Hospital between February 1, 2019, and January 31, 2020. Participants’ demographic data, willingness, and motivations for biospecimen donation were collected and analyzed.ResultsOf 670 participants, 90.8% (318/350) in the Guardian group and 88.1% (282/320) in the Adult group completed the questionnaire. Most participants were willing to donate residual tissue samples (92.8% in the Guardian group vs. 79.4% in the Adult group, pψ = 0.032) and clinical data (94.0% vs. 72.3%, pψ < 0.001) for medical research. Logistic regression analysis indicated that only child status (odds ratio [OR] = 0.140, p = 0.02), history of blood donation (OR = 4.467, p = 0.019) in the Guardian group, education (OR = 0.387, p = 0.037), and history of blood donation (OR = 2.556, p = 0.016) in the Adult group were significantly associated with participants’ willingness to donate biospecimens. The primary motivation for donation was helping other patients with cancer (65.4% vs. 24.5%, pψ < 0.001). The major barriers to donation were the potential to cause physical discomfort (61.0% vs. 64.9%, pψ = 0.032).ConclusionsGuardians of children with cancer were more willing to donate biospecimens than adult cancer patients in China. It is essential to promote awareness of biospecimens donation, especially in adult cancer patients.
Quality Evaluation of Wild Germplasm of Chinese Prickly Ash (Zanthoxylum bungeanum Maxim) from Qinling Mountains at Different Elevations Based on HPLC‐Fingerprint**
Authors: Zheng Tao , Su Ke‐Xing , Chen Xi‐Yan , Zhang Ding‐Ling , Liu Shu‐Ming 
Published: February 2022

AbstractWild Chinese prickly ash resources provide a valuable genetic resource for Zanthoxylum bungeanum Maxim improvement and breeding. The Qinling Mountains was an abundant source for wild Chinese prickly ash. In this study, the phenolic and flavonoid compounds of wild germplasm resources from different altitudes and six cultivated varieties were analyzed by high performance liquid chromatography (HPLC). The chromatograms of them were essentially consistent, although their chemical composition contents were greatly different. The thirty samples were divided into three categories through the hierarchical clustering analysis. Catechin, hyperoside and quercitrin were considered to be key compounds for the quality evaluation, and by contrast, the wild samples with an altitude of 2300±50 m (Group IV) had the highest content of key compounds, and presented stronger antioxidant activity and antibacterial ability, indicating that these wild samples could be identified as the excellent breeding resources. This is the first time to evaluate the quality of wild Chinese prickly ash at different altitudes in Qinling Mountains. These excellent wild germplasm resources provided substantial potential accessions for use directly in Chinese prickly ash breeding programs.
Emerging role of m6A modification in cardiovascular diseases
Authors: Peng Liming , Long Tianyi , Li Fei , Xie Qiying 
Published: February 2022

AbstractCardiovascular diseases (CVDs) contribute to the leading cause of death worldwide. Despite significant improvements in CVDs diagnosis and treatment, a continued effort to explore novel therapeutic strategies is urgently need. N6‐methyladenosine (m6A) RNA methylation, well known as the most prevalent type of RNA modifications, involved in RNA stability, nuclear exports, translation, and decoy, plays a crucial role in the pathogenesis of a variety of diseases, including CVDs, cancer, and drug resistance. Here, our article summarizes cellular functions of m6A modulators and recent research progress concerning the functions and mechanisms of m6A methylation in CVDs, in hope of providing references for exploring novel therapeutic approaches and potential biomarkers in the treatment of CVDs.
Usefulness of intravascular ultrasound to assess coronary occlusion after transcatheter aortic valve replacement
Authors: Valvo Roberto , Costa Giuliano , Tamburino Corrado , Barbanti Marco 
Published: February 2022

AbstractTranscatheter aortic valve replacement (TAVR) is now a proven treatment option for patients with severe aortic stenosis. Coronary ostia obstruction is a rare but a life‐threatening complication of TAVR. In case of suspected coronary ostia obstruction, intravascular ultrasound study (IVUS) assessment could be feasible and useful to evaluate coronary ostia patency after the transcatheter aortic valve deployment, in high‐risk scenarios for coronary occlusion. We described the case of a 73‐year‐old female with delayed coronary obstruction after TAVR with a 23‐mm SAPIEN 3 ULTRA who underwent IVUS‐guided percutaneous coronary intervention, using the chimney stenting technique, due to critical ostium left main impingement.
Myelomatous ascites and pleural effusion in relapsed multiple myeloma
Authors: Baksh Mizba , Li Ke , Jiang Liuyan , Alegria Victoria , Sher Taimur , Roy Vivek , Chanan‐Khan Asher , Ailawadhi Sikander , Parrondo Ricardo D. , Alhaj Moustafa Muhamad 
Published: February 2022

AbstractExtramedullary multiple myeloma is seen in advanced and aggressive disease and occurs due to plasma cell infiltration of sites other than the bone marrow. Myelomatous ascites or pleural effusion is seen in less than 1% of cases and can be differentiated from infectious etiologies based on fluid cytology.
Double appendixes: A rare case report
Authors: Markou Markos , Sotiropoulou Rodopi , Perente Sempachedin , Kougioumtzi Ioanna‐Triada , Foutzitzi Soultana , Chatzipantelis Paschalis , Botaitis Sotirios 
Published: February 2022

AbstractAnomalies of the appendix are rare, and one of the rarest is the double appendixes. Most anomalies of the appendix are observed in adults and are discovered incidentally during surgery that does not primarily involve the appendix. It is usually missed, often with life‐threatening consequences.
Multi‐mode grounding and monophasic passive discharge stimulation avoid aberrant facial nerve stimulation following cochlear implantation
Authors: Zellhuber Nina , Helbig Ralf , James Paul , Bloching Marc , Lyutenski Stefan 
Published: February 2022

AbstractWe report on a case with severe facial nerve stimulation via a cochlea‐facial nerve dehiscence that was most likely the result of prolonged occlusive hydrocephalus. The successful treatment of this adverse effect demonstrates for the first time its complete resolution using a multi‐mode grounding and monophasic passive discharge stimulation.
Unilateral eosinophilic cellulitis leading to implant extrusion after bilateral enucleation in a dog
Authors: Aronson Riley J. , Pumphrey Stephanie A. , Robinson Nicholas 
Published: February 2022

AbstractA mixed breed dog underwent bilateral enucleation with orbital implant placement for secondary glaucoma. Subsequent unilateral implant extrusion occurred. An orbital mass histologically consistent with eosinophilic cellulitis was discovered. It may have developed secondary to communication between orbit and skin. Inflammatory processes mimicking neoplasia can cause implant loss post‐enucleation.
A Semiconductor‐Mediator‐Catalyst Artificial Photosynthetic System for Photoelectrochemical Water Oxidation
Authors: Niu Fujun , Wang Degao , Williams Lenzi J. , Nayak Animesh , Li Fei , Chen Xiangyan , Troian‐Gautier Ludovic , Huang Qing , Liu Yanming , Brennaman M. Kyle , Papanikolas John M. , Guo Liejin , Shen Shaohua , Meyer Thomas J. 
Published: February 2022

AbstractIn fabricating an artificial photosynthesis (AP) electrode for water oxidation, we have devised a semiconductor‐mediator‐catalyst structure that mimics photosystem II (PSII). It is based on a surface layer of vertically grown nanorods of Fe2O3 on fluorine doped tin oxide (FTO) electrodes with a carbazole mediator base and a Ru(II) carbene complex on a nanolayer of TiO2 as a water oxidation co‐catalyst. The resulting hybrid assembly, FTO|Fe2O3|−carbazole|TiO2|−Ru(carbene), demonstrates an enhanced photoelectrochemical (PEC) water oxidation performance compared to an electrode without the added carbaozle base with an increase in photocurrent density of 2.2‐fold at 0.95 V vs. NHE and a negatively shifted onset potential of 500 mV. The enhanced PEC performance is attributable to carbazole mediator accelerated interfacial hole transfer from Fe2O3 to the Ru(II) carbene co‐catalyst, with an improved effective surface area for the water oxidation reaction and reduced charge transfer resistance.
Produktlebensdaten für eine textile Kreislaufwirtschaft
Authors: Müller Kai , Hartmann Philipp , Gehrke Inga , Gries Thomas 
Published: February 2022

AbstractDas geschlossene Produktlebenszyklusmanagement stellt einen spannenden Lösungsansatz für die Textilbranche dar, um durch neue Technologien in der Datenerfassung sowie der durchgängigen Informationssteuerung die Herausforderungen einer stärkeren Kundenorie
Energieeffiziente Trockner ‐entfernen Schadstoffe
Authors: Weinert Harald 
Published: February 2022

AbstractEin Großteil unserer alltäglichen Gebrauchsgegenstände enthalten sog. VOC (volatile organic compounds), das sind flüchtige organische Verbindungen bzw. Gas‐ und dampfförmige Stoffe mit z. T. extremem Geruch und gesundheitsschädlichen Auswirkungen für Mensch und Umwelt. Mit der Entwicklung und des zum Patent angemeldeten eVOC‐Verfahrens vereint die Simar GmbH ein effizientes Verfahren zur VOC‐Reduzierung mit modernster Trocknungstechnik und beweist somit eindeutig Gespür für die aktuellen Anforderungen des Marktes und deren erfolgreiche Umsetzung. Die neueste Entwicklung, der eVOC Entgasungstrockner, setzt ganz neue Maßstäbe im Bereich der Trocknungstechnik.