bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Reversible Moisture‐Induced Bright Self‐Trapped Exciton Emissions in a Copper‐Based Organic–Inorganic Hybrid Metal Halide
Authors: Fang Shaofan , Zhou Bo , Li Huixia , Hu Hanlin , Zhong Haizhe , Li Henan , Shi Yumeng 
Published: May 2022

AbstractMetal halide perovskites are promising optoelectronic materials due to their unique luminescent properties. However, their practical application is limited by their poor chemical stability, especially in humid environments. Moisture can cause phase changes or chemical decomposition, resulting in significant fluorescence quenching. In this study, a copper‐based organic–inorganic hybrid metal halide (t‐BA)3Cu6I9 is synthesized (t‐BA+ is the tert‐butyl‐ammonium ion (C(CH3)3NH3+)). This material exhibits water‐induced luminescence, and its chemical stability in humid environments is being investigated. Tetragonal t‐BA3Cu6I9 is not luminescent, but it reacts quickly with water in the air. The resultant (t‐BA)2Cu2I4·H2O has a broad green emission peak at 520 nm, high photoluminescence quantum yield of 59.4%. Remarkably, (t‐BA)2Cu2I4·H2O is converted back to t‐BA3Cu6I9 at temperatures above 40 °C. This phase conversion is highly repeatable, and the luminescent intensity can be fully recovered after 50 transformation cycles. The mechanism of luminescence is investigated through temperature‐dependent photoluminescence spectra and theoretical calculation, which suggests that (t‐BA)2Cu2I4·H2O has a more localized charge distribution and sufficient polyhedral distortion, resulting in a bright and efficient emission from self‐trapped excitons. This is the first report of water‐induced luminescence in copper‐based metal halides, and it paves the way for stable luminescent materials that are responsive to humidity.
Bimetallic Intersection in PdFe@FeOx‐C Nanomaterial for Enhanced Water Splitting Electrocatalysis
Authors: Martinez Jordan , Mazarío Jaime , Olloqui‐Sariego José Luis , Calvente Juan José , Darawsheh Mohanad D. , Mínguez‐Espallargas Guillermo , E. Domine Marcelo , Oña‐Burgos Pascual 
Published: May 2022

AbstractSupported Fe‐doped Pd‐nanoparticles (NPs) are prepared via soft transformation of a PdFe‐metal oraganic framework (MOF). The thus synthesized bimetallic PdFe‐NPs are supported on FeOx@C layers, which are essential for developing well‐defined and distributed small NPs, 2.3 nm with 35% metal loading. They are used as bifunctional nanocatalysts for the electrocatalytic water splitting process. They display superior mass activity for the oxygen evolution reaction (OER) and the hydrogen evolution reaction (HER), both in alkaline and acid media, compared with those obtained for benchmarking platinum HER catalyst, and ruthenium, and iridium oxide OER catalysts. PdFe‐NPs also exhibit outstanding stability against sintering that can be explained by the protecting role of graphitic carbon layers provided by the organic linker of the MOF. Additionally, the superior electrocatalytic performance of the bimetallic PdFe‐NPs compared with those of monometallic Pd/C NPs and FeOx points to a synergetic effect induced by Fe–Pd interactions that facilitates the water splitting reaction. This is supported by additional characterization of the PdFe‐NPs prior and post electrolysis by TEM, XRD, X‐ray photoelectron spectroscopy, and Raman revealing that dispersed PdFe NPs on FeOx@C promote interactions between Pd and Fe, most likely to be Pd–O–Fe active centers.
Crosslinked alginate‐xanthan gum blends as effective hydrogels for 3D bioprinting of biological tissues
Authors: Taniguchi Nagahara Mariana Harue , Caiado Decarli Monize , Inforçatti Neto Paulo , Lopes da Silva Jorge Vicente , Moraes Ângela Maria 
Published: May 2022

Abstract3D bioprinting has a high potential for directly printing customized tissues and organs for surgical transplantation. However, adequate bioink formulations, in which cells can be combined with proper fluids for bioprinting structures with complex architectures, are still needed. In this work, we have combined alginate and xanthan gum in different proportions, aiming at producing an effective noncytotoxic, shear‐thinning, and easily sterilizable hydrogel, crosslinkable by the addition of low amounts of strontium ions, which would lead to stronger structures than those crosslinked with calcium. The results attained show that increases in xanthan gum concentration improve the rheological behavior of the material regarding printability and that heat‐sterilized formulations can show adequate rheological performance for bioprinting. Stable and noncytotoxic structures were obtained with a hydrogel consisting of 1% (w/v) alginate and 2.5% (w/v) xanthan gum in α‐MEM supplemented culture medium crosslinked by immersion in 50 mmol L−1 strontium chloride solution for 10 min postprinting. In conclusion, this new hydrogel formulation, optimized for bioink production, is designed to mimic the extracellular matrix with significant potential to be used for a wide plethora of applications, from the production of simple cellularized structures useful in drug screening and as microtissue models to complex organ bioprinting.
Toward heat resistant polylactide blend fibers via incorporation of low poly[(R)‐3‐hydroxybutyrate‐co‐4‐hydroxybutyrate] content
Authors: Shi Yamin , Huang Wei , Li Yi , Wang Wenling , Sui Miao , Yang Qiu , Tong Yi , Yang Kai , Chen Peng 
Published: May 2022

AbstractBlending high content of polyhydroxyalkanoates (PHAs ≥ 30 wt.%) with polylactide (PLA) provides an effective strategy to significantly improve heat resistance of PLA fibers. However, it has proven challenging to maintain good spinnability of the PLA/PHAs blends with the high content of PHAs. In this study, a series of poly(L‐lactide) (PLLA)/poly[(R)‐3‐hydroxybutyrate‐co‐4‐hydroxybutyrate] (P34HB) blend fibers with low P34HB content (≤ 8 wt.%) is successfully fabricated with excellent spinnability. The incorporation of P34HB contributes to a substantially improved heat resistance of the PLLA/P34HB blend fibers, as evidenced by a notable reduction in boiling water shrinkage from ca. 80% to 9%. This exceptionally improved heat resistance is closely related to substantial increase in crystallinity of PLLA in the blend fibers. Specifically, the addition of low P34HB content remarkably enhances chain mobility of PLLA chains, as such reduces crystallization half‐times (t1/2) and accelerates crystallization of PLLA. In fact, the amorphous P34HB phase favors crystal growth of PLLA phase rather than heterogeneous nucleation inferred previously. These results provide a facile and effective method to produce PLLA/P34HB blend fibers with enhanced heat resistance and sound spinnability.
Multiresidue analysis and probabilistic dietary risk assessment of 241 pesticides in wheatgrass (Triticum sp.) using LC–MS/MS in combination with QuEChERS extraction
Authors: Goel Vikrant , Pandey Deepika , Shukla Sudeep 
Published: May 2022

AbstractWheatgrass is consumed as an important nutritious herbal food supplement across the globe; however, limited studies have been reported analyzing multiclass pesticides in this complex, nutrient‐rich natural product. An analytical method was developed for the estimation of 241 pesticides in random wheatgrass samples collected from Delhi Northern Capital Region (Delhi‐NCR). Extraction was performed by QuEChERS, cleaning was performed by dispersive solid‐phase extraction and the extracts were analyzed using triple quadrupole liquid chromatography mass spectrometry. The limit of quantification was 0.5 μg/kg, which is well below the European Union Maximum Residue Level. The coefficient of determination was >0.991 across a calibration range of 0.5–100 μg/kg. The relative standard deviation values for 231 pesticides based on 10 replicates of samples spiked at 10 μg/kg were <5%. Among random samples, 54% confirmed the presence of at least one pesticide. The results indicated the presence of eight different pesticides among 38% of the total population with metribuzin at 299.7 μg/kg and carfentrazone‐ethyl at 19.47 μg/kg exceeding the permissible limits among 6% of the total estimated population. The chronic and acute risk quotients as calculated were <1, indicating nonsignificant dietary risk to consumers. However, the presence of pesticides above the permissible limit is likely to result in adverse health effects to the consumers of herbal supplements from an urban population and incorporating measures would be useful to ensure the quality and safety of wheatgrass consumption.
UPLC‐Q‐Exactive/MS–based metabonomics revealed protective effect of Zingiberis rhizome and its processed product on deficiency‐cold and hemorrhagic syndrome rats
Authors: Yang Rui , Zhang Ying , Wang Lvhong , Cheng Pei , Sun Yue , Cao Hui , Wang Shumei , Wu Liang , Meng Jiang 
Published: May 2022

AbstractZingiberis rhizome carbonisata (ZRC) is the processed product of Zingiberis rhizome (ZR). ZR is mainly used for warming the spleen and stomach to dispel cold, whereas ZRC is commonly applied as a treatment for deficiency‐cold and hemorrhagic syndrome (DCHS). Although they have long been used to serve different clinical purposes, the specific action mechanism of the drugs and molecular changes underlying ZR processing are not clear. In this study, metabolomics study was carried out to analyze the alterations in endogenous metabolites in serum and urine samples of DCHS rat models using ultra‐high‐performance liquid chromatography coupled with quadrupole‐Exactive mass spectrometry technique and constructed principal component analysis score plots that showed that the ZRC group was completely separated from the DCHS and ZR groups but demonstrated a highly close plotting to the normal control group. The results revealed that both ZR and ZRC intervened in the metabolic pathways of DCHS models but to varying degrees and with different influencing factors. In addition, ZRC was found to function as a treatment for the metabolic disorders of DCHS through 15 pharmacodynamic biomarkers involving a series of pathways, such as glycine, serine, and threonine metabolic pathway, as well as arachidonic acid metabolic pathways. This study showed that metabolomics method based on ultra‐high‐performance liquid chromatography coupled with quadrupole‐Exactive mass spectrometry could preliminarily illuminate the therapeutic mechanism of ZR and ZRC on DCHS and the changes in ZR processing from the molecular‐level perspective. The results also provided new insight into further research on DCHS treatment.
Maternal major depression disorder misclassification errors: Remedies for valid individual‐ and population‐level inference
Authors: Owora Arthur H. 
Published: May 2022

AbstractIndividual and population level inference about risk and burden of MDD, particularly maternal MDD, is often made using case‐finding tools that are imperfect and prone to misclassification error (i.e. false positives and negatives). These errors or biases are rarely accounted for and lead to inappropriate clinical decisions, inefficient allocation of scarce resources, and poor planning of maternal MDD prevention and treatment interventions. The argument that the use of existing maternal MDD case‐finding instruments results in misclassification errors is not new; in fact, it has been argued for decades, but by and large its implications and particularly how to correct for these errors for valid inference is unexplored. Correction of the estimates of maternal MDD prevalence, case‐finding tool sensitivity and specificity is possible and should be done to inform valid individual and population‐level inferences.
Prognosis prediction of stage IV colorectal cancer patients by mRNA transcriptional profile
Authors: Wu Bian , Yang Jinwei , Qin Zhiwei , Yang Hongping , Shao Jingyi , Shang Yun 
Published: May 2022

AbstractBackgroundStage IV colorectal cancer patients with liver metastasis represent a special group of CRC patients with poor prognosis. The prognostic factors have not been investigated for stage IV CRC patients undergoing primary cancer resection but not candidates for metastasis resection.MethodsNinety‐nine stage IV CRC patients who underwent primary cancer resection without metastasis resection were retrospectively recruited. Both whole‐exome sequencing (WES) and RNA‐seq were performed with frozen primary cancer tissues, using para‐cancerous normal tissues as the control. Valid data were obtained from 78 patients for WES and 84 patients for RNA‐seq. Univariate, multivariate Cox analyses were performed and Nomogram model was established to predict patient prognosis.ResultsThe correlation between patient prognosis and clinicopathological factors, mutational status, or mRNA level changes was examined. Univariate (p = 0.0007) and subsequent multivariate analyses on clinicopathological factors showed that location (left or right) was the only independent risk factor for patient prognosis (HR = 3.63; 95% CI: 1.56–8.40, p = 0.003), while T, N, M staging, gender, race, location (rectum or colon), and pathological types were not stratifying factors. The mutational status of APC, TP53, KRAS, TTN, SYNE1, SMAD4, PIK3CA, RYR2, and BRAF did not show significant stratification in patient prognosis. RNA‐seq showed that genes related to membrane function, ion channels, transporters, or receptors were among those with significant mRNA level alterations. Univariate analysis identified 97 genes with significantly altered mRNA levels, while NEUROD1, FGF18, SFTA2, PLAC1, SAA2, DSCAML1, and OTOP3 were significant in multivariate analysis. A risk model was established to stratify the prognosis of stage IV CRC patients. A Nomogram model was established with these genes to predict individual patient prognosis.ConclusionsA panel of eight genes with significant mRNA level alterations was capable of predicting the prognosis and risk of the specific patient group. Future prospective study is needed to validate the model.
The effect of exercise training on endothelial function in postmenopausal women with breast cancer under aromatase inhibitor therapy
Authors: Mayr Barbara , Reich Bernhard , Greil Richard , Niebauer Josef 
Published: May 2022

AbstractBackgroundBreast cancer is the leading non‐cardiovascular cause of death in women. In endocrine receptor positive women, aromatase inhibitors (AI) are the therapy of choice despite the fact that a decrease in systemic estrogen levels may result in endothelial dysfunction and eventually in cardiovascular disease. In this study, we assessed whether exercise training (ET), which has repeatedly shown to lead to an improvement of endothelial dysfunction, will also exert this effect in postmenopausal women with AI treated breast cancer.MethodsThirty two postmenopausal women with AI treated breast cancer were randomized to an intervention group (ET; 6 months, supervised training plus 6 months without intervention) or control group of usual care (UC; 12 months without intervention plus initial exercise counseling). Endothelial function was assessed via Reactive Hyperemia Index (RHI) measured non‐invasively with the EndoPAT‐System at baseline, 6 and 12 months.ResultsAfter 6 months of supervised ET, changes in maximal exercise capacity were significantly greater in ET than in UC (∆W: 24.1 ± 11.5 vs. 1.1 ± 8.2 watts; p < 0.001). Even though 43.8% of all participants had endothelial dysfunction at baseline, there were no significant group differences in the changes of RHI between ET (∆RHI: −0.1 ± 1.04) and UC (0.02 ± 0.75; p = 0.323) after 6 months.ConclusionEven though ET led to significantly greater improvement in exercise capacity in postmenopausal women with AI treated breast cancer than exercise counseling only, it did not exert any measurable effects on endothelial dysfunction.
Repair of double orifice mitral valve with an atrioventricular septal defect in a girl with Ellis–Van Creveld syndrome
Authors: Al‐Dairy Alwaleed , Srour Samir , Chaker Alaa , Alzahraa Alsyed Hasan Fatimah 
Published: May 2022

AbstractEllis–van Creveld syndrome is a rare autosomal recessive disorder caused by mutations in the EVC and EVC2 genes. The four principal manifestations are chondrodysplasia, polydactyly, ectodermal dysplasia, and congenital heart defects. We describe the case of a 7‐year‐old girl with Ellis–van Creveld Syndrome with the diagnosis of common atrium and partial atrioventricular septal defect. She underwent a successful surgical repair, and intraoperatively, a double orifice mitral valve was diagnosed as well. The correct diagnosis of this disorder in early life is essential in the overall prognosis of the syndrome. Clinical follow‐up at regular intervals is very important in these patients to institute proper managements and prevent further complications.
Efficient Removal Technology of Ammonia Nitrogen by Membrane Separation
Authors: Li Peng , Jin Longyi 
Published: May 2022

AbstractThe working principle, process flow, treatment effect, and application scope of ammonia nitrogen removal by membrane separation were investigated. The effects of initial ammonia nitrogen concentration, pH value, and flow rate of raw water on mass transfer coefficient and removal rate of ammonia nitrogen in the membrane separation process were evaluated, and the optimal operating conditions of membrane separation were assessed. In addition, several kinds of representative wastewaters were treated. Under the optimal operating conditions, the ammonia nitrogen removal rate can reach more than 99 % and the specific surface area can be up to 3000 m2m−3.
How and when corporate social performance reduces firm risk? The moderating role of corporate governance
Authors: Nirino Niccolò , Battisti Enrico , Ferraris Alberto , Dell'Atti Stefano , Briamonte Massimiliano Farina 
Published: May 2022

AbstractThis study aims to explore the impact of corporate social performance (CSP) on firm risk, and it proposes the moderating role of corporate governance (CG) among this relationship. Although the literature on corporate social responsibility is extensive, there is still a lack of knowledge about how CSP influences firm risks, as well as the role of CG in this relationship. To fill this gap, we have empirically tested the impact of CSP on a firm's risk through a longitudinal analysis on S&P 500 firms from 2015 to 2019. Results show a significant negative relationship between CSP and firm risks, which is positively moderated by CG mechanisms. Our study contributes to the empirical research on corporate social responsibility and it provides insights for managerial decisions to encourage managers to pursue environmental and social practices that reduce the firm risk, with positive impacts on the firm value.
Restoring function: Positive responses of carbon and nitrogen to 20 years of hydrologic restoration in montane meadows
Authors: Reed Cody C. , Berhe Asmeret A. , Moreland Kimber C. , Wilcox Jim , Sullivan Benjamin W. 
Published: May 2022

AbstractMontane meadows are highly productive ecosystems that contain high densities of soil carbon (C) and nitrogen (N). However, anthropogenic disturbances that have led to channel incision and disconnected floodplain hydrology have altered the C balance of many meadows, converting them from net C sinks to net sources of C to the atmosphere. Restoration efforts designed to reconnect floodplain hydrology may slow rates of soil C loss from degraded meadows and restore the conditions for C sequestration and N immobilization, yet questions remain about the long‐term impact of such efforts. Here, we used a 22‐year meadow restoration chronosequence to measure the decadal impact of hydrologic restoration on aboveground and belowground C and N stocks and concentrations. Increases in herbaceous vegetation biomass preceded changes in soil C stocks, with the largest gains occurring belowground. Root biomass (0–15 cm) increased at a rate of 270.3 g m−2 year−1 and soil C stocks (0–15 cm) increased by 232.9 g C m−2 year−1 across the chronosequence. Increases in soil C concentration (2.99 g C kg−1 year−1) were tightly coupled with increases in soil N concentration (0.21 g N kg−1 year−1) and soil C:N did not vary with time since restoration. Fourier transform infrared spectroscopy results showed that the fraction of labile aliphatic C–H and carboxylate C–O (COO) compounds in the soil increased with the age of restoration and were positively correlated with soil C and N concentrations. Our results demonstrate that restoration of floodplain hydrology in montane meadows has significant impacts on belowground C and N stocks, soil C and N concentration, and soil C chemistry within the first two decades following restoration.
Antioxidant Activity of Methyl Caffeate‐Enriched Olive Oils: From Extra Virgin Olive Oil to Extra Virgin Olive Oil‐Based Microemulsions
Authors: Galani Eleni , Chatzidaki Maria D. , Fokas Demosthenes , Xenakis Aristotelis , Roussis Ioannis G. 
Published: May 2022

AbstractOxidative rancidity isthe main cause of extra virgin olive oil's (EVOO) quality deterioration. Here, methyl caffeate (CAME) is examined for possibly enhancing EVOO antioxidant activity. To improve CAME's solubility and efficacy, an EVOO‐based water in oil microemulsion is used. The oxidative stability of EVOO is monitored. The antioxidant activity of EVOO is assessed both by 2,2‐diphenyl‐1‐picrylhydrazyl free radical scavenging and electron paramagnetic resonance (EPR) spectroscopy. Microemulsions’ antioxidant activity is also determined by EPR spectroscopy. CAME's presence is found to increasethe oxidative stability, the antioxidant capacity, and the total phenolic content of the samples. The increase is dose‐dependent according to the added ester amount. The use of EVOO‐based microemulsions increases the ester's solubility rendering sonication unnecessary. The ester also improves the microemulsions’ oxidative stability.Practical applications: The CAME enhancement of EVOO's antioxidant capacity can find direct application for improving the quality of oils with less nutritional value. The EVOO‐based microemulsions can serve as functional oleaginous ingredients and delivery vehicles in several applications such as cosmetics, pharmaceuticals, and foods. The beneficial compounds of EVOO, combined with the chosen encapsulated substance, can be a powerful ingredient, of a chosen functionality.