bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enantioselective Synthesis of [5]Helicenes Containing Two Additional Chiral Axes
Authors: Zhang Jianwei , Simon Martin , Golz Christopher , Alcarazo Manuel 
Published: October 2022

AbstractA Au‐catalyzed protocol for the enantioselective synthesis of molecular architectures containing an internal [5]helicene and two peripherical axial stereogenic elements is described. While the diasteroselectivity of the double alkyne hydroarylation sequence is not optimal, and mixtures that contain similar amounts of two of the four possible diasteromeric products are obtained (one C2 and one non‐symmetric), the assembly of the C2‐symmetric isomer often occurs with high enantioselectivity (up to 98 % ee). The absolute configurations of the products obtained were determined by X‐ray crystallography. Studies on the thermal racemization of the internal [5]helicene moiety in the C2‐symmetric isomers determined the half‐life of this element to be approximately 3 h at 50 °C.
Recurrent multiple liver metastases of clear cell renal cell carcinoma with a significant response to sunitinib after nivolumab treatment
Authors: Tada Kouki , Daizumoto Kei , Takahashi Masayuki , Uehara Hisanori , Tsuda Megumi , Kusuhara Yoshito , Fukawa Tomoya , Yamamoto Yasuyo , Yamaguchi Kunihisa , Kanayama Hiro‐omi 
Published: October 2022

IntroductionA case of multiple liver metastases of clear cell RCC with a significant response to sunitinib as the fifth line after nivolumab is reported.Case presentationThe patient was a 65‐year‐old man who underwent open nephrectomy for RCC. After the nephrectomy, he had recurrences several times, and metastasectomy had been performed for each recurrence. At 13 years after the nephrectomy, multiple liver, and lung metastases appeared. The treatment was switched to axitinib, followed by cabozantinib, then nivolumab. The best response was PR, SD, and PD for these three drugs, and treatment duration was 14, 3, and 3 months, respectively. As the fifth line, sunitinib was administered, with significant shrinkage of the multiple liver metastases, and PR has been maintained for 34 months.ConclusionSunitinib after an IO‐drug showed a significant effect in spite of only slight efficacy with other VEGFR‐TKIs, which may have occurred through the alteration of the immunological microenvironment.
IntramuscularEMGclassifier for detecting myopathy and neuropathy
Authors: Jose Shobha , Selvaraj Thomas George , Samuel Kenneth , Philip Jobin T. , Nanjappan Jothiraj Sairamya , Muthu Swamy Pandian Subathra , Handiru Vikram Shenoy , Suviseshamuthu Easter S. 
Published: October 2022

AbstractThis article presents an automatic diagnostic system to classify intramuscular electromyography (iEMG) signals, thereby detecting neuromuscular disorders. To this end, we tailored the center symmetric local binary pattern (CSLBP) to analyze one‐dimensional (‐D) signals. In this approach, the ‐D CSLBP feature extracted from a decimated iEMG signal is fed to a combination of classifiers, which in turn assigns a set of labels to the signal, and ultimately the signal category is determined by the Boyer‐Moore majority voting (BMMV) algorithm. The proposed framework was investigated with a benchmark iEMG dataset that contains signals recorded from three different muscles:biceps brachii(BB),deltoideus(DE), andvastus medialis(VM). In a repeated ‐fold cross‐validation, CSLBP‐Combined‐Classifiers‐BMMV (CSLBP‐CC‐BMMV) achieved an average classification accuracy of %, %, and % for the iEMG signals recorded from BB, DE, and VM muscle, respectively. Interestingly, the performance of CSLBP‐CC‐BMMV surpassed the other published approaches and ensemble learning methods that are akin to our scheme in terms of classification accuracy and computational time.
Polarization clustering of biological structures with Mueller matrix parameters
Authors: Chen Yongtai , Chu Jinkui , Lin Fanlu , Jiang Bing , Liu Yadong , Huang Bo , Zhang Ran , Xin Benda , Ding Xiaohan 
Published: October 2022

AbstractMueller matrix imaging polarimetry (MMIP) is a promising technique for the characterization of biological tissues, including the classification of microstructures in pathological diagnosis. To expand the parameter space of Mueller matrix parameters, we propose new vector parameters (VPs) according to the Mueller matrix polar decomposition method. We measure invasive bladder cancer (IBC) with extensive necrosis and high‐grade ductal carcinoma in situ (DCIS) with MMIP, and the regions of cancer cells and fibrotic stroma are classified with the VPs. Then the proposed and existing VPs are mapped on the Poincaré sphere with 3D visualization, and an indicator of spatial feature is defined based on the minimum enclosing sphere to evaluate the classification capability of the VPs. For both IBC and DCIS, the results show that the proposed VPs exhibit evident contrast between the regions of cancer cells and fibrotic stroma. This study broadens the fundamental Mueller matrix parameters and helps to improve the characterization ability of the MMIP technique.
A discourse analysis of cultural humility within counseling dyads
Authors: Zhu Peitao , Isawi Dana T. , Luke Melissa M. 
Published: October 2022

AbstractA growing body of empirical literature has substantiated that cultural humility (CH) contributes meaningfully to a variety of therapeutic processes and outcomes. However, no study has concretely described how CH is linguistically and discursively enacted within therapeutic exchanges. Using interactional sociolinguistic discourse analysis, we explored the sociolinguistic strategies along with three dimensions of CH: (a) cultural teachability, (b) lack of cultural arrogance, and (c) relational orientation. Participants included six pairs of cross‐racial counseling dyads. Our analyses of the session and follow‐up interview transcripts yielded a range of sociolinguistic strategies (i.e., positioning, use of reinforcement, repetition, and use of pronouns) corresponding to the CH dimensions. We discuss clinical, research, and training implications.
Race, masks, residency and concern regarding COVID‐19 transmission
Authors: Azhar Sameena , Rahman Rahbel , Wernick Laura J. , Tripathi Saumya , Cohen Margaret , Maschi Tina 
Published: October 2022

AbstractTo explore sociodemographic predictors for concern regarding COVID‐19 transmission and how these factors interact with the identities of others, we conducted a web‐based survey where we asked 568 respondents in the United States to indicate their level of COVID‐19 concern in response to a series of images with short vignettes of masked and unmasked individuals of different racial/ethnic backgrounds. Using a linear mixed effects model, we found that regardless of the race of the image being presented in the vignette, concern regarding COVID‐19 transmission was associated with respondents' older age (b = 0.029, p < 0.001), residing in NYC (b = 0.556, p = 0.009), being heterosexual (b = 1.075, p < 0.001), having higher levels of education, that is, completion of a Bachelor's degree (b = 1.10, p = 0.033) or graduate degree (b = 1.78, p < 0.001), and the person in the vignette being unmasked (b = 0.822, p < 0.001). Asian respondents were more likely than White respondents to be concerned regarding COVID‐19. Individuals who self‐reported themselves to be at high risk for COVID‐19 were more likely to be concerned about COVID‐19 over those who considered themselves to be low risk. These findings highlight the importance of acknowledging interactions between race, mask status, and residency in predicting COVID‐19 concern.
The role of ferroptosis in the development of acute and chronic kidney diseases
Authors: Zhou Yijun , Zhang Junlan , Guan Qingyan , Tao Xun , Wang Jinling , Li Wentong 
Published: October 2022

AbstractFerroptosis, a novel form of regulated cell death, is characterized by imbalance of intracellular iron and redox systems, resulting from overgeneration of toxic lipid peroxidation products. In recent years, the verified crucial role of ferroptosis has been widely concerned in rudimentary pathogenesis and development of various acute and chronic kidney disease (CKD), comprehending the potential patterns of cell death can afford more reliable bases and principles for treatment and prevention of renal disease. In this review, the regulatory mechanisms of ferroptosis were introduced and the important roles of ferroptosis in diverse renal diseases such as acute kidney injury, CKD, and renal fibrosis were outlined to illuminate the potential of restraining ferroptosis in treatment and prevention of kidney disease.
Pyruvate dehydrogenase kinase 4 promotes ubiquitin–proteasome system‐dependent muscle atrophy
Authors: Sinam Ibotombi Singh , Chanda Dipanjan , Thoudam Themis , Kim Min‐Ji , Kim Byung‐Gyu , Kang Hyeon‐Ji , Lee Jung Yi , Baek Seung‐Hoon , Kim Shin‐Yoon , Shim Bum Jin , Ryu Dongryeol , Jeon Jae‐Han , Lee In‐Kyu 
Published: October 2022

AbstractBackgroundMuscle atrophy, leading to muscular dysfunction and weakness, is an adverse outcome of sustained period of glucocorticoids usage. However, the molecular mechanism underlying this detrimental condition is currently unclear. Pyruvate dehydrogenase kinase 4 (PDK4), a central regulator of cellular energy metabolism, is highly expressed in skeletal muscle and has been implicated in the pathogenesis of several diseases. The current study was designed to investigated and delineate the role of PDK4 in the context of muscle atrophy, which could be identified as a potential therapeutic avenue to protect against dexamethasone‐induced muscle wasting.MethodsThe dexamethasone‐induced muscle atrophy in C2C12 myotubes was evaluated at the molecular level by expression of key genes and proteins involved in myogenesis, using immunoblotting and qPCR analyses. Muscle dysfunction was studied in vivo in wild‐type and PDK4 knockout mice treated with dexamethasone (25 mg/kg body weight, i.p., 10 days). Body weight, grip strength, muscle weight and muscle histology were assessed. The expression of myogenesis markers were analysed using qPCR, immunoblotting and immunoprecipitation. The study was extended to in vitro human skeletal muscle atrophy analysis.ResultsKnockdown of PDK4 was found to prevent glucocorticoid‐induced muscle atrophy and dysfunction in C2C12 myotubes, which was indicated by induction of myogenin (0.3271 ± 0.102 vs 2.163 ± 0.192, ****P < 0.0001) and myosin heavy chain (0.3901 ± 0.047 vs. 0.7222 ± 0.082, **P < 0.01) protein levels and reduction of muscle atrophy F‐box (10.77 ± 2.674 vs. 1.518 ± 0.172, **P < 0.01) expression. In dexamethasone‐induced muscle atrophy model, mice with genetic ablation of PDK4 revealed increased muscle strength (162.1 ± 22.75 vs. 200.1 ± 37.09 g, ***P < 0.001) and muscle fibres (54.20 ± 11.85% vs. 84.07 ± 28.41%, ****P < 0.0001). To explore the mechanism, we performed coimmunoprecipitation and liquid chromatography‐mass spectrometry analysis and found that myogenin is novel substrate of PDK4. PDK4 phosphorylates myogenin at S43/T57 amino acid residues, which facilitates the recruitment of muscle atrophy F‐box to myogenin and leads to its subsequent ubiquitination and degradation. Finally, overexpression of non‐phosphorylatable myogenin mutant using intramuscular injection prevented dexamethasone‐induced muscle atrophy and preserved muscle fibres.ConclusionsWe have demonstrated that PDK4 mediates dexamethasone‐induced skeletal muscle atrophy. Mechanistically, PDK4 phosphorylates and degrades myogenin via recruitment of E3 ubiquitin ligase, muscle atrophy F‐box. Rescue of muscle regeneration by genetic ablation of PDK4 or overexpression of non‐phosphorylatable myogenin mutant indicates PDK4 as an amenable therapeutic target in muscle atrophy.
The (t−1) $(t-1)$‐chromatic Ramsey number for paths
Authors: Bucić Matija , Khamseh Amir 
Published: October 2022

AbstractThe following relaxation of the classical problem of determining the Ramsey number of a fixed graph has first been proposed by Erdős, Hajnal and Rado over 50 years ago. Given a graph and an integer determine the minimum number such that in any ‐coloured complete graph on vertices there is a copy of using only edges of some colours. We determine the answer precisely when is a path.
Comprehensive data of 4502 patients newly diagnosed with colorectal liver metastasis between 2015 and 2017, and prognostic data of 2427 patients newly diagnosed with colorectal liver metastasis in 2013 and 2014: Third report of a nationwide survey in Japan
Authors: Sakamoto Katsunori , Beppu Toru , Honda Goro , Kotake Kenjiro , Yamamoto Masakazu , Takahashi Keiichi , Endo Itaru , Hasegawa Kiyoshi , Itabashi Michio , Hashiguchi Yojiro , Kotera Yoshihito , Kobayashi Shin , Yamaguchi Tatsuro , Natsume Soichiro , Tabuchi Ken , Kobayashi Hirotoshi , Yamaguchi Kensei , Tani Kimitaka , Morita Satoshi , Miyazaki Masaru , Sugihara Kenichi 
Published: October 2022

AbstractTo improve treatment outcomes in patients with colorectal liver metastasis (CRLM), the Joint Committee for Nationwide Survey on CRLM was established by the Japanese Society for Cancer of the Colon and Rectum and the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery. The aim of the study was to evaluate transition in the characteristics and treatment strategy in CRLM patients and analyze prognostic factors using large‐scale data. The present study summarizes the data of patients newly diagnosed between 2015 and 2017 and presents prognostic data of patients newly diagnosed in 2013 and 2014. Survival curves were generated by the Kaplan–Meier method and compared by log‐rank test. Multivariate analyses were carried out using Cox proportional hazard modeling. The data of 4502 patients newly diagnosed with CRLM between 2015 and 2017 and the prognostic data of 2427 patients diagnosed in 2013 and 2014 are included. Regarding the 2013 and 2014 prognostic data, the 5‐year overall survival (OS) rates of patients who underwent hepatectomy alone was 59.8%. Multivariate analyses identified age at diagnosis of CRLM ≥70 years, concomitant extrahepatic metastasis at diagnosis of CRLM, tumor depth of primary lesion ≥subserosa/pericolic or perirectal tissue, mutant KRAS status, number of CRLM ≥5, maximum diameter of CRLM >5 cm, and surgical curability R1/R2 as independent predictors of OS. Analysis of the latest nationwide database of patients diagnosed with CRLM revealed changes in patients and oncological characteristics, a transition in treatment strategy, and different independent prognosticators to those reported previously.
Pyridazinones: A versatile scaffold in the development of potential target‐based novel anticancer agents
Authors: Singh Jyoti , Kumar Vipan , Silakari Pragati , Kumar Sandeep 
Published: October 2022

AbstractPyridazinones are important nitrogen‐rich heterocyclic core that has been driving the substantial medicinal interest due to their wide range of biological activities. This privileged scaffold forms a central core in numerous potent compounds, which results in the development of novel anticancer drugs with fruitful biological activities. The current review article summarizes the progressive development of novel pyridazinone derivatives that are targets for numerous receptors such as C‐met kinase inhibitors, PARP inhibitors, Tubulin polymerization inhibitors, Dihydro folate reductase inhibitors, B‐Raf inhibitors, Bruton tyrosine kinase inhibitors, FER tyrosine kinase inhibitors, and fibroblast growth factors receptors. It features the various simple techniques for the synthesis of pyridazinones and also highlights the mechanistic insights into the anticancer properties of pyridazinone derivatives.
Making the Case for Joint Decision‐Making in Future Multipurpose Prevention Technology (MPT) Choice: Qualitative Findings on MPT Attribute Preferences from the CUPID Study (MTN‐045)
Authors: Bhushan Nivedita L. , Musara Petina , Hartmann Miriam , Stoner Marie C. D. , Shah Shweta R. , Nabukeera Josephine , Rukundo Ivan , Mutero Prisca , Lewis Megan A. , Piper Jeanna , Shapley‐Quinn Mary Kate , Etima Juliane , Minnis Alexandra M. 
Published: October 2022

AbstractIntroductionYoung women in sub‐Saharan Africa account for two‐thirds of all new HIV infections and face high rates of unintended pregnancy. Multipurpose prevention technologies (MPTs) are promising products under development that are designed to simultaneously prevent HIV and unintended pregnancy. Since MPTs will be used in the context of sexual relationships, ensuring acceptability and use requires understanding the role of male partners in MPT use decision‐making.MethodsThis paper draws on qualitative data from 39 couples enrolled in the Microbicide Trials Network (MTN) 045 study, conducted in 2019–2020. Partners completed a discrete choice experiment (DCE), first separately and then jointly, to measure preferences for future MPT attributes and then completed a qualitative interview. We also draw on quantitative data from interviewer observation about who dominated the decision‐making process during the joint DCE. Content analysis was used to examine (1) how couples made decisions on existing non‐MPT HIV and pregnancy prevention products; (2) how couples made decisions on future ideal‐MPT product during the DCE; and (3) how these decision‐making processes varied by decision‐making dominance (10 male, 10 female and 19 equal) and interview type (19 joint and 20 separate).ResultsExisting non‐MPT product decisions focused on trust between partners and product attributes, while future ideal‐MPT product decisions exclusively focused on product attributes. Across existing and future products, preferences for product attributes varied by gender. Male partners were most concerned with limiting side effects impacting sexual pleasure, female partners were most concerned with limiting side effects causing physical symptoms and both were concerned with the return to fertility. Across all dominance and interview types, couples reported making decisions together and female partners were often able to negotiate with male partners for their preferred product or set of product attributes.ConclusionsResearch activities in this study provided an opportunity for couples to openly present their product attribute preferences to their partner, learn about their partner's attribute preferences, negotiate for their ideal set of attributes and ultimately choose attributes that benefited the couple without disempowering the female partner. Future research should focus on the utility of couple‐based decision‐making aids or similar tools for facilitating joint MPT decision‐making.
Systematic analysis to identify novel disease indications and plausible potential chemical leads of glutamate ionotropic receptorNMDAtype subunit 1,GRIN1
Authors: Bhardwaj Tulika , Ahmad Irshad , Somvanshi Pallavi 
Published: October 2022

AbstractSchizophrenia is a mental illness affecting the normal lifestyle of adults and early adolescents incurring major symptoms as jumbled speech, involvement in everyday activities eventually got reduced, patients always struggle with attention and memory, reason being both the genetic and environmental factors responsible for altered brain chemistry and structure, resulting in schizophrenia and associated orphan diseases. The network biology describes the interactions among genes/proteins encoding molecular mechanisms of biological processes, development, and diseases. Besides, all the molecular networks, protein‐protein Interaction Networks have been significant in distinguishing the pathogenesis of diseases and thereby drug discovery. The present meta‐analysis prioritizes novel disease indications viz. rare and orphan diseases associated with target Glutamate Ionotropic Receptor NMDA Type Subunit 1, GRIN1 using text mining knowledge‐based tools. Furthermore, ZINC database was virtually screened, and binding conformation of selected compounds was performed and resulted in the identification of Narciclasine (ZINC04097652) and Alvespimycin (ZINC73138787) as potential inhibitors. Furthermore, docked complexes were subjected to MD simulation studies which suggests that the identified leads could be a better potential drug to recuperate schizophrenia.
Nomogram Estimating Vessels Encapsulating Tumor Clusters in Hepatocellular Carcinoma From Preoperative Gadoxetate Disodium‐Enhanced MRI
Authors: Chen Fang‐Ming , Du Mingzhan , Qi Xiumin , Bian Linjie , Wu Danping , Zhang Shuang‐Lin , Wang Jitao , Zhou Yongping , Zhu Xiaoli 
Published: October 2022

BackgroundVessels encapsulating tumor clusters (VETC) pattern is a novel microvascular pattern associated with poor outcomes of hepatocellular carcinoma (HCC). Preoperative estimation of VETC has potential to improve treatment decisions.PurposeTo develop and validate a nomogram based on gadoxetate disodium‐enhanced MRI for estimating VETC in HCC and to evaluate whether the estimations are associated with recurrence after hepatic resection.Study TypeRetrospective.PopulationA total of 320 patients with HCC and histopathologic VETC pattern assessment from three centers (development cohort:validation cohort = 173:147).Field Strength/SequenceA3.0  T/turbo spin‐echo T2‐weighted, spin‐echo echo‐planar diffusion‐weighted, and 3D T1‐weighted gradient‐echo sequences.AssessmentA set of previously reported VETC‐ and/or prognosis‐correlated qualitative and quantitative imaging features were assessed. Clinical and imaging variables were compared based on histopathologic VETC status to investigate factors indicating VETC pattern. A regression‐based nomogram was then constructed using the significant factors for VETC pattern. The nomogram‐estimated VETC stratification was assessed for its association with recurrence.Statistical TestsFisher exact test, t‐test or Mann–Whitney test, logistic regression analyses, Harrell's concordance index (C‐index), nomogram, Kaplan–Meier curves and log‐rank tests. P value < 0.05 was considered statistically significant.ResultsPathological VETC pattern presence was identified in 156 patients (development cohort:validation cohort = 83:73). Tumor size, presence of heterogeneous enhancement with septations or with irregular ring‐like structures, and necrosis were significant factors for estimating VETC pattern. The nomogram incorporating these indicators showed good discrimination with a C‐index of 0.870 (development cohort) and 0.862 (validation cohort). Significant differences in recurrence rates between the nomogram‐estimated high‐risk VETC group and low‐risk VETC group were found (2‐year recurrence rates, 50.7% vs. 30.3% and 49.6% vs. 31.8% in the development and validation cohorts, respectively).Data ConclusionThe nomogram integrating gadoxetate disodium‐enhanced MRI features was associated with VETC pattern preoperatively and with postoperative recurrence in patients with HCC.Evidence Level4Technical EfficacyStage 2