bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of nonovarian cancer in a nationwide‐based study of nearly 5000 women with borderline ovarian tumors in Denmark
Authors: Hannibal Charlotte G. , Baandrup Louise , Hertzum‐Larsen Rasmus , Vang Russell , Kurman Robert J. , Frederiksen Kirsten , Kjaer Susanne Krüger 
Published: November 2022

AbstractEvidence regarding cancer risk after borderline ovarian tumors (BOTs) is limited. We conducted a nationwide cohort study examining the incidence of nonovarian cancers in women with serous or mucinous BOTs compared with the general female population with up to 41 years of follow‐up. Through the nationwide Pathology Registry, we identified nearly 5000 women with BOTs (2506 serous and 2493 mucinous) in Denmark, 1978 to 2018. We computed standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) as relative risk estimates of specific nonovarian cancers. Compared with general female population rates, women with serous BOTs had increased rates of particularly malignant melanoma (SIR = 1.9; 95% CI: 1.3‐2.6), thyroid cancer (SIR = 3.0; 95% CI: 1.4‐5.4) and myeloid leukemia (SIR = 3.2; 95% CI: 1.5‐5.8), and women with mucinous BOTs had elevated rates of lung cancer (SIR = 1.7; 95% CI: 1.3‐2.1), pancreatic cancer (SIR = 1.9; 95% CI: 1.2‐2.9) and myeloid leukemia (SIR = 2.3; 95% CI: 0.9‐4.7). We found no convincing association with neither breast nor colorectal cancer in women with BOTs. This is the first large nationwide study showing that women with specific types of BOTs have increased risks of several nonovarian cancers, likely due to some shared risk factors or genetic characteristics.
Evidence for exposure biomarkers in dictamnine‐induced liver injury resulting from metabolic activation in vitro and in mice
Authors: Li Zhuo‐Qing , Zhang Cai , Fan Song , Wang Ling‐Li , Jiang Yan , Li Hui‐Jun 
Published: November 2022

AbstractDictamnine (DTN), a furoquinoline alkaloid isolated from Dictamni Cortex, is responsible for the liver injury caused by Dictamni Cortex and the preparations. Discovering new biomarkers with high specificity and sensitivity for diagnosis and tracing the source of DTN‐induced liver injury is urgently needed. Considering that metabolic activation of DTN has been suggested as a primary trigger initiating hepatotoxicity, the present study aimed to investigate the bio‐activation process of DTN in vitro and in mice and to explore whether the adducts could be developed as exposure biomarkers. When trapping with N‐acetyl‐cysteine (NAC) and glutathione (GSH) in mouse liver microsomes and CYP3A4 overexpressed L02 cells, two isomers of DTN‐NAC adducts were detected in both systems and one DTN‐GSH adduct was found in mouse liver microsomes. As expected, one DTN‐NAC adduct was also found in plasma and bile of mice with liver injury after DTN exposure. Moreover, mouse liver microsomes were used to simulate the conjugation of serum albumin with metabolically activated DTN. The sole modified peptide 25DAHKSEVAHR34 was found, and the oxidative metabolites of DTN might bind to the side chain amino of albumin at Arg34. The above findings not only provided confirmative evidence that DTN was metabolically activated to induce liver injury but also suggested that the adducts had the potential to be developed as exposure biomarkers of DTN‐induced liver injury.
Hamilton‐connected {claw,net}‐free graphs, II
Authors: Liu Xia , Ryjáček Zdeněk , Vrána Petr , Xiong Liming , Yang Xiaojing 
Published: November 2022

AbstractIn the first one in this series of two papers, we have proved that every 3‐connected ‐free graph is Hamilton‐connected. In this paper, we continue in this direction by proving that every 3‐connected ‐free graph, where , is Hamilton‐connected (where is the graph obtained by attaching endvertices of three paths of lengths to a triangle). This together with a previous result of other authors completes the characterization of forbidden induced generalized nets implying Hamilton‐connectedness of a 3‐connected claw‐free graph. We also discuss remaining open cases in a full characterization of connected graphs such that every 3‐connected ‐free graph is Hamilton‐connected.
The association between serum 25‐hydroxyvitamin D and the prevalence of herpes simplex virus
Authors: Huang Jiaofeng , Wu Yinlian , Wang Mingfang , Lin Su 
Published: November 2022

AbstractPrevious studies have reported a potential anti‐infection effect for vitamin D. However, the relationship between vitamin D status and herpes simplex virus (HSV) infection has not yet been evaluated. Therefore, this study aimed to determine the association between serum 25‐hydroxyvitamin D [25(OH)D] and infection with HSV types 1 and 2 (HSV‐1 and HSV‐2). Data were collected from the National Health and Nutrition Examination Survey from 2007 to 2016. The association between 25(OH)D and HSV prevalence was evaluated using propensity score matching (PSM) and univariate and multivariate logistic regression analyses. Overall, 14 174 participants were included in the final analysis. Before PSM, 8639 (60.9%) had positive HSV‐1 and 2636 (18.6%) had HSV‐2. The HSV‐1 and HSV‐2 positive groups had more females and older individuals (p < 0.05). The HSV‐2 patients had lower 25(OH)D levels than those with HSV‐1. Age and gender did not differ in the groups after PSM (p > 0.05). The 25(OH)D level was significantly lower in the HSV‐1 and HSV‐2 groups than in the non‐HSV infection groups. Multivariate logistic regression showed that serum 25(OH)D level was negatively associated with HSV‐1 and HSV‐2 infection (odds ratio [OR] = 0.730 and 0.691, p < 0.001, respectively). Vitamin D deficiency was an independent risk factor for both HSV‐1 and HSV‐2 (adjusted OR = 2.205 and 2.704, p < 0.001, respectively). Lower serum 25(OH)D levels correlated significantly with increased HSV‐1 and HSV‐2 infection risk.
Facile Synthesis of Zinc‐Containing Mesoporous Silicate from Iron Tailings and Enhanced Fire Retardancy of Rigid Polyurethane Foam
Authors: Yang Yadong , Yang Sujie , Jiang Shudong , Liu Mengru , Liu Xiuyu , Tang Gang , Cai Ren , Tan Weihong 
Published: November 2022

AbstractIron tailings (ITS), as solid decay absolved afterward beneficiation, are adverse to the environment. ITS to prepare zinc‐containing mesoporous silicate (MAO‐Zn) by a calcination‐crystallization method are used. An admixture of ammonium polyphosphate (APP) and MAO‐Zn can solve the problem of poor flame retardancy in rigid polyurethane foam (RPUF), giving them higher thermal stability and lower heat release. The total heat release rate and smoke factor values exhibited by RPUF‐3 are 24.52 MJ m−2 and 234.29 MW m−2 respectively, a decrease of 38.45% and 29.60% respectively compared to pure RPUF. Lower combustible and toxic gas release intensities are in RPUF‐3. Meanwhile, RPUF‐3 possesses enhanced compactness char residue with higher graphitization degree, endowing RPUF‐3 with excellent fire observed performance. This work demonstrates the potential of ITS in the fire retardancy field.
Compound heterozygous loss‐of‐function variants in BRAT1 cause lethal neonatal rigidity and multifocal seizure syndrome
Authors: Li Shan , Yu Shunan , Zhang Yanzhuo , Wang Ying , Jiang Xu , Wu Chengai 
Published: November 2022

AbstractBackgroundLethal neonatal rigidity and multifocal seizure syndrome (RMFSL, OMIM 614498) is a rare autosomal recessive disease characterized by the onset of rigidity and intractable seizures at or soon after birth. The BRAT1 has been identified to be the disease‐causing gene for RMFSL. This study aimed to determine the underlying pathogenic mutations of a Chinese family with RMFSL and to confirm the effect of the splice‐site mutation by reverse transcription analysis.MethodsDetailed family history and clinical data were recorded, and peripheral blood samples were collected from all available family members. Whole exome sequencing (WES), Sanger sequencing, and bioinformatics analysis were performed to investigate the causative variants. The impact of the intronic variant on splicing was subsequently analyzed by RT‐PCR analysis.ResultsWe identified two compound heterozygous variants in the BRAT1, c.431‐2A>G in intron 3 and c.1359_1361del(p.Leu454del) in exon 9 in the proband, one inherited from each parent. Furthermore, the 3′‐splice site acceptor (c.431‐2A>G) variant was found to activate a cryptic acceptor splice site, which resulted in the loss of 29 nucleotides and generation of a premature stop codon at code 180, producing a truncated BRAT1 (c.432_460del; p.Ala145Argfs*36).ConclusionsThis research identified two mutations in the BRAT1 of one Chinese family with RMFSL. These data can aid in developing clinical diagnoses as well as providing genetic counseling and prenatal interventions to the family. These findings also expand our knowledge of the spectrum of BRAT1 pathogenic variants in RMFSL syndrome.
The FADS1 rs174550 Genotype Modifies the n‐3 and n‐6 PUFA and Lipid Mediator Responses to a High Alpha‐Linolenic Acid and High Linoleic Acid Diets
Authors: Meuronen Topi , Lankinen Maria A. , Kolmert Johan , de Mello Vanessa Derenji , Sallinen Taisa , Ågren Jyrki , Virtanen Kirsi A. , Laakso Markku , Wheelock Craig E. , Pihlajamäki Jussi , Schwab Ursula 
Published: November 2022

ScopeThe fatty acid composition of plasma lipids, which is associated with biomarkers and risk of non‐communicable diseases, is regulated by dietary polyunsaturated fatty acids (PUFAs) and variants of fatty acid desaturase (FADS). We investigated the interactions between dietary PUFAs and FADS1 rs174550 variant.Methods and resultsParticipants (n = 118), homozygous for FADS1 rs174550 variant (TT and CC) followed a high alpha‐linolenic acid (ALA, 5 percent of energy (E‐%)) or a high linoleic acid (LA, 10 E‐%) diet during an 8‐week randomized controlled intervention. Fatty acid composition of plasma lipids and PUFA‐derived lipid mediators were quantified by gas and liquid chromatography mass spectrometry, respectively. The high‐LA diet increased the concentration of plasma LA, but not its lipid mediators. The concentration of plasma arachidonic acid decreased in carriers of CC and remained unchanged in the TT genotype. The high‐ALA diet increased the concentration of plasma ALA and its cytochrome P450‐derived epoxides and dihydroxys, and cyclooxygenase‐derived monohydroxys. Concentrations of plasma eicosapentaenoic acid and its mono‐ and dihydroxys increased only in TT genotype carriers.ConclusionsThese findings suggest the potential for genotype‐based recommendations for PUFA consumption, resulting in modulation of bioactive lipid mediators which can exert beneficial effects in maintaining health.
Frequency discrimination based on the different number of peaks in envelope detection of two‐tone continuous‐wave radar systems
Authors: Sim Jae Young , Yang Jong‐Ryul 
Published: November 2022

AbstractThis study proposed a method for distinguishing the baseband signal for each frequency in two‐tone radar systems using the difference in the number of peaks of the envelope detected signal. The proposed method is based on the characteristic that the baseband signal for each frequency exhibits a different number of peaks, depending on the operating frequency, at a fixed sampling frequency in data acquisition. The phase difference between the transmitting and receiving signals for each frequency can be obtained using envelope detection of the baseband signals in two‐tone radar systems, and the proposed method can effectively match the phase difference and operating frequency without using additional controls and synchronization. This simplifies the procedure to estimate the absolute range up to the maximum unambiguous range, corresponding to a phase difference of 2π. Measurement results demonstrate that the absolute range, using a two‐tone radar with a frequency spacing of 150 MHz, can detect the distance with an accuracy of 97.8% up to the maximum unambiguous range using the proposed method.
Design and fabrication of rudimentary shaped and effective 1 × 2 printed MIMO antenna using low profile material for WLAN and satellite applications
Authors: Vala Kaushal , Hadia Sarman K. 
Published: November 2022

AbstractThe presented article represents the rudimentary‐shaped effective 1 × 2 MIMO antenna structure. The five variation types in the ground region shape are analyzed. The structure's total dimensions are 40 × 36 × 1.6 mm3. For efficiently manufacturing, the low‐profile substrate FR4 is employed, and the reflectance response of a simulated and modelled design is compared. The placement of two T‐shaped slits in the ground area aids in achieving a wider bandwidth, multiband response, excellent Gain, and directivity. Overall, the PW:4 has a minimum reflectance coefficient of −34.54 dB, a broad bandwidth of 3.38 GHz, a peak gain of 13.02 dB, maximum narrow band isolation of 62 dB, and a maximum normalized directivity of 156°. The Envelop Correlation Coefficient, Channel Capacity Loss, Total Active Reflection Coefficient, and Diversity Gain for MIMO design are also examined. These findings indicate the provided design's behavior as per the standard requirements.
A double‐blind placebo‐controlled pilot study of immunoglobulin for small fiber neuropathy associated with TS‐HDS and FGFR‐3 autoantibodies
Authors: Gibbons Christopher H. , Rajan Sharika , Senechal Katherine , Hendry Erin , McCallister Brady , Levine Todd D. 
Published: November 2022

AbstractIntroduction/AimsSmall fiber neuropathies (SFN) have been associated with two autoantibodies, trisulfated heparin disaccharide (TS‐HDS) and fibroblast growth factor receptor 3 (FGFR‐3), and intravenous immune globulin (IVIG) has been suggested as a potential therapy. The study objective is to determine the efficacy of IVIG on nerve density, pain and neurologic examinations in patients with SFN associated with TS‐HDS and FGFR‐3 autoantibodies.MethodsThis was a double‐blind placebo‐controlled pilot study. Subjects with SFN confirmed by history, examination, and skin biopsy with elevated autoantibodies to TS‐HDS and/or FGFR‐3 received IVIG (or blinded placebo) 2 grams/kg followed by 1 gram/kg every 3 wk for a total of 6 treatments. All subjects had Utah Early Neuropathy Scores (UENS), questionnaires and skin biopsies with quantitation of intra‐epidermal nerve fiber density (IENFD) taken from adjacent sites at the distal leg at baseline and 6 mo later. The primary outcome was the change in IENFD over 6 mo.ResultsTwenty subjects were enrolled; 17 completed treatment (8 IVIG, 9 placebo). Three did not have final data due to coronavirus disease 2019 (COVID‐19). Skin biopsy IENFD improved by 0.5 ± 0.8 fibers/mm in the placebo group and improved by 0.6 ± 0.6 fibers/mm in the IVIG‐treated group (p = NS).Over 24 wk the change in pain scores (11 point pain scale) was −1.9 ± 2.6 in the placebo group, and − 1.7 ± 0.9 in the IVIG group (p = NS), the UENS improved by 3.0 ± 5.8 in the placebo group and improved by 1.8 ± 3.9 in the IVIG group (p = NS).DiscussionThis pilot study did not detect a benefit of treatment with IVIG in patients with SFN and autoantibodies to TS‐HDS and FGFR‐3.
The Effect of Harvest Regulations on White Crappie Fisheries in Kansas Impoundments
Authors: Miazga James R. , Klein Zachary B. , Koch Jeff D. , Neely Ben C. 
Published: November 2022

Abstract
Crappie Pomoxis spp. (White Crappie P. annularis and Black Crappie P. nigromaculatus) support important harvest-oriented fisheries throughout the United States. However, effects of harvest regulations vary among crappie populations and fisheries managers have little guidance for selecting the most appropriate regulatory scenario given the diversity of crappie populations throughout their distribution. In an effort to guide successful implementation of White Crappie harvest regulations, we evaluated the influence of daily creel limits and minimum length limits (MLLs) on White Crappie fisheries from a diverse suite of Kansas impoundments. White Crappie populations were sampled from 39 impoundments in 2019 and 2020, and a subsample was sacrificed for age and growth estimation. Creel data from 22 impoundments were used to estimate percent reduction in harvest when daily creel limits ranged from liberal (50 fish/d) to more restrictive (5 fish/d). Equilibrium yield models were used to evaluate the effects of various MLL regulations (203, 254, and 305 mm) on yield, the number of White Crappie harvested, and the number reaching memorable length (300 mm). Our results suggest that daily creel limits would need to be less than 10 crappie/d to reduce harvest by more than 25%. In general, the 254-mm MLL was the most effective harvest regulation for improving yield when the growth rate was above average, conditional natural mortality was low, and exploitation was at least moderate—factors commonly associated with populations in large impoundments in this study. In populations characterized by slow growth, liberal daily creel limits (50 fish/d) may be best suited to maximize yield. Overall, our results provide a framework for fisheries managers to make informed decisions regarding implementation of harvest regulations for crappie in impoundments throughout the Central Plains region.
Structural design and impact resistance of three‐dimensional structure‐reinforced flexible polymer composites
Authors: Li Xiangmian , Zhang Xingteng , Yan Ruosi , Jia Lixia 
Published: November 2022

AbstractThree‐dimensional (3D) structure‐reinforced flexible polymer composites have great potential as personal protective materials. These composites exhibit excellent mechanical properties and failure mechanisms than typical rigid composites because of the complex dynamic reaction processes caused by the 3D structure in response to impact. This paper comprehensively reviews the impact resistance mechanism of 3D structure‐reinforced flexible polymer composites by combining current results with relevant investigations. 3D woven fabric reinforcements and flexible matrix materials of flexible polymer composites systems are presented in this paper. The classification for 3D woven fabric reinforcements is reviewed, as well as the effect of reinforcement structures on the impact resistance of the flexible composites. Furthermore, several flexible matrix are introduced. Several external factors affecting the impact resistance of composites are then discussed. Finally, the impact damage mechanism of 3D structure‐reinforced flexible polymer composites is summarized and analyzed.
Stromal transdifferentiation drives lipomatosis and induces extensive vascular remodeling in the aging human lymph node
Authors: Bekkhus Tove , Olofsson Anna , Sun Ying , Magnusson Peetra U , Ulvmar Maria H 
Published: November 2022

AbstractLymph node (LN) lipomatosis is a common but rarely discussed phenomenon associated with aging that involves a gradual exchange of the LN parenchyma into adipose tissue. The mechanisms behind these changes and the effects on the LN are unknown. We show that LN lipomatosis starts in the medullary regions of the human LN and link the initiation of lipomatosis to transdifferentiation of LN fibroblasts into adipocytes. The latter is associated with a downregulation of lymphotoxin beta expression. We also show that isolated medullary and CD34+ fibroblasts, in contrast to the reticular cells of the T‐cell zone, display an inherently higher sensitivity for adipogenesis. Progression of lipomatosis leads to a gradual loss of the medullary lymphatic network, but at later stages, collecting‐like lymphatic vessels are found inside the adipose tissue. The stromal dysregulation includes a dramatic remodeling and dilation of the high endothelial venules associated with reduced density of naïve T‐cells. Abnormal clustering of plasma cells is also observed. Thus, LN lipomatosis causes widespread stromal dysfunction with consequences for the immune contexture of the human LN. Our data warrant an increased awareness of LN lipomatosis as a factor contributing to decreased immune functions in the elderly and in disease. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
BepiPred‐3.0: Improved B‐cell epitope prediction using protein language models
Authors: Clifford Joakim Nøddeskov , Høie Magnus Haraldson , Deleuran Sebastian , Peters Bjoern , Nielsen Morten , Marcatili Paolo 
Published: November 2022

AbstractB‐cell epitope prediction tools are of great medical and commercial interest due to their practical applications in vaccine development and disease diagnostics. The introduction of protein language models (LMs), trained on unprecedented large datasets of protein sequences and structures, tap into a powerful numeric representation that can be exploited to accurately predict local and global protein structural features from amino acid sequences only. In this paper, we present BepiPred‐3.0, a sequence‐based epitope prediction tool that, by exploiting LM embeddings, greatly improves the prediction accuracy for both linear and conformational epitope prediction on several independent test sets. Furthermore, by carefully selecting additional input variables and epitope residue annotation strategy, performance was further improved, thus achieving unprecedented predictive power. Our tool can predict epitopes across hundreds of sequences in minutes. It is freely available as a web server and a standalone package at https://services.healthtech.dtu.dk/service.php?BepiPred-3.0 with a user‐friendly interface to navigate the results.
Incorporation of noninvasive assessments in risk prediction for pulmonary arterial hypertension
Authors: Quan Ruilin , Chen Xiaoxi , Yang Tao , Li Wen , Qian Yuling , Lin Yangyi , Xiong Changming , Shan Guangliang , Gu Qing , He Jianguo 
Published: November 2022

AbstractRisk assessment for pulmonary arterial hypertension (PAH) utilizing noninvasive prognostic variables could be more practical in real‐world scenarios, especially at follow‐up reevaluations. Patients who underwent comprehensive evaluations both at baseline and at follow‐up visits were enrolled. The primary endpoint was all‐cause mortality. Predictive variables identified by Cox analyses were further incorporated with the French noninvasive risk prediction approach. A total of 580 PAH patients were enrolled. During a median follow‐up time of 47.0 months, 112 patients (19.3%) died. By multivariate Cox analyses, tricuspid annular plane systolic excursion (TAPSE), TAPSE/pulmonary arterial systolic pressure (PASP), and cardiopulmonary exercise testing‐derived peak oxygen consumption (VO2) remained independent predictors for survival. Regarding the French noninvasive risk prediction method, substituting N‐terminal pro‐b‐type natriuretic peptide (NT‐proBNP) with the newly derived low‐risk criteria of a TAPSE ≥ 17 mm or a TAPSE/PASP > 0.17 mm/mmHg, or alternating 6‐min walking distance with a peak VO2 ≥ 44 %predicted retained the discrimination power. When recombining the low‐risk criteria, the combination of World Health Organization functional class (WHO FC), TAPSE and peak VO2 at baseline, and the combination of WHO FC, NT‐proBNP, and peak VO2 at follow‐up showed better discriminative ability than the other combinations. In conclusion, Peak VO2, TAPSE, and TAPSE/PASP are significant prognostic predictors for survival in PAH, with incremental prognostic value when incorporated with the French noninvasive risk prediction approach, especially at reevaluations. For better risk prediction, WHO FC, at least one measurement of exercise capacity and one measurement of right ventricular function should be considered.