bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reproducibility and Scattering in Additive Manufacturing: Results from a Round Robin on PBF-LB/M AlSi10Mg Alloy
Authors: Schneider M. , Bettge D. , Binder M. , Dollmeier K. , Dreyer M. , Hilgenberg K. , Klöden B. , Schlingmann T. , Schmidt J. 
Published: September 2022

Abstract
The round robin test investigated the reliability users can expect for AlSi10Mg additive manufactured specimens by laser powder bed fusion through examining powder quality, process parameter, microstructure defects, strength and fatigue. Besides for one outlier, expected static material properties could be found. Optical microstructure inspection was beneficial to determine true porosity and porosity types to explain the occurring scatter in properties. Fractographic analyses reveal that the fatigue crack propagation starts at the rough as-built surface for all specimens. Statistical analysis of the scatter in fatigue using statistical derived safety factors concludes that at a stress of 36.87 MPa the fatigue limit of 107 cycles could be reached for all specimen with a survival probability of 99.999 %.
Endocrine-related adverse conditions in patients receiving immune checkpoint inhibition: an ESE clinical practice guideline
Authors: Husebye Eystein S , Castinetti Frederik , Criseno Sherwin , Curigliano Giuseppe , Decallonne Brigitte , Fleseriu Maria , Higham Claire E , Lupi Isabella , Paschou Stavroula A , Toth Miklos , van der Kooij Monique , Dekkers Olaf M 
Published: September 2022

Abstract
Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment but are associated with significant autoimmune endocrinopathies that pose both diagnostic and treatment challenges. The aim of this guideline is to provide clinicians with the best possible evidence-based recommendations for treatment and follow-up of patients with ICI-induced endocrine side-effects based on the Grading of Recommendations Assessment, Development, and Evaluation system. As these drugs have been used for a relatively short time, large systematic investigations are scarce. A systematic approach to diagnosis, treatment, and follow-up is needed, including baseline tests of endocrine function before each treatment cycle. We conclude that there is no clear evidence for the benefit of high-dose glucocorticoids to treat endocrine toxicities with the possible exceptions of severe thyroid eye disease and hypophysitis affecting the visual apparatus. With the exception of thyroiditis, most endocrine dysfunctions appear to be permanent regardless of ICI discontinuation. Thus, the development of endocrinopathies does not dictate a need to stop ICI treatment.
Antibacterial effects of vanilla ingredients provide novel treatment options for infections with multidrug-resistant bacteria – A recent literature review
Authors: Maisch Noah A. , Bereswill Stefan , Heimesaat Markus M. 
Published: September 2022

Abstract
Due to the increasing application of antibiotics not only in healthcare settings but also in conventional agriculture and farming, multidrug-resistant (MDR) bacterial pathogens are rising worldwide. Given the increasing prevalence of infections caused by MDR bacteria such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species (ESKAPE pathogen complex), it is pivotal to explore novel alternative or adjunct treatment options such as phytochemicals with antibiotic properties. Vanillin and vanillin acid represent biologically active ingredients in vanilla that has been known for long for its health-beneficial including antimicrobial effects besides its role as flavoring agent. Therefore, we performed a literature search from the past 10 years summarizing the knowledge regarding the effects of vanilla constituents against bacterial including MDR pathogens. Our survey revealed that vanillin and vanillic acid exerted potent effects directed against distinct Gram-positive and Gram-negative bacteria by inhibiting growth, viability, biofilm formation, quorum sensing and virulence. Remarkably, when combining vanillin or vanillic acid with defined synthetic antibiotics pronounced synergistic effects directed against distinct pathogenic including ESCAPE strains could be observed. In conclusion, vanilla ingredients constitute promising alternative or adjunct options in the combat of infections caused by MDR bacterial pathogens.
Validity and Reliability of Polar V800 Smart Watch to Measure Cricket-Specific Movements
Authors: Biswas Subhashis , Guha Supratim , Bhattacharya Rupayan 
Published: September 2022

The study purpose was to assess the reliability and validity of Polar V800 smart watch in measuring various cricket-specific movements.
Materials and methods. Only one trained male volunteer was selected to perform all the cricket specific movements to minimize individual error and eliminate between-subject variability. Polar V800 obtained distances were compared with real field markings.
Results. Split-half Reliability Statistical method has been used and 'r' score for the measurements taken has been found to be 0.93. 95% confidence intervals also express a good reliability score. The criterion validity method was used to determine the validity of the dataset. The Pearson correlations (r) have been found ranging from 0.86 to 0.99. Predicted best fit line of linear regression has been found as y = 0.9722 X + 0.0046 (where y = observed value, X = real field distance). One way ANOVA followed by Tukey’s post hoc test on observed 10m sprint, 20m sprint and run-a-three movements show maximum significant difference with other cricket-specific movements. The mean percentage of bias for all cricket-specific movements has been found to be -2.20 ± 13.17.
Conclusions. The study reveals that Polar V800 smart watch has an acceptable accuracy, reliability, and validity for measuring various cricket specific movements with certain limitations.
Assessment of the Quality of Active Family Leisure
Authors: Maltsev Dmytro , Andrieieva Olena , Kashuba Vitalii , Yarmak Olena , Dobrodub Evgeniia , Grygus Igor , Prusik Krzysztof 
Published: September 2022

Study purpose. The study was aimed at assessing the quality of active family leisure and identifying motivations for and interests in health-enhancing and recreational physical activity of parents and children.
Materials and methods. The study involved 106 families. A set of generally accepted research methods was used including theoretical analysis and generalization of scientific and methodological literature as well as domestic and international practical experience related to family leisure; sociological methods (questionnaire surveys), and mathematical statistics methods.
Results. The questionnaire survey provided an opportunity to identify priority areas of joint physical activity of children and parents and to assess the quality of family well-being and active family leisure. The attitude of parents to winter types of recreation in the organization of active leisure was identified. According to the survey data, 9.4% of the families had a high level, 59.4% had an average level, 30.3% had a satisfactory level, and 0.9% had an unsatisfactory level of family well-being. The vast majority of respondents (45.2%) believed that their family members had a satisfactory level of physical activity, 40.6% of families reported they had an average level, only 10.4% indicated they had a high level, and 3.8% said they had an unsatisfactory level. Among the surveyed families, 63.2% indicated an average level of satisfaction with family leisure, 29.2% rated their leisure as satisfactory, and the remaining 3.8% indicated an excellent or unsatisfactory level.
Conclusions. The focus was on identifying prevailing motivations, which contribute to the optimization of the family leisure process and the degree of activity when using recreational technologies. The obtained results indicate a significant potential for expanding physical activity of families with children, including through the use of winter recreation.
Abuse of dominant position when unaccounted for consumption of electrical energy is detected
Authors: Melnik A. N. 
Published: September 2022

The problem of abuse of use of a dominant position by the subjects of retail electricity markets — grid organizations, guaranteeing suppliers when conducting checks of subscriber metering devices, drawing up acts on unmetered electricity consumption, drawing up invoices for payment of the volume of identified unmetered consumption was studied.The concept of unaccounted consumption of electric energy is given, frequent violations by professional participants in the wholesale electricity markets are identified when unaccounted consumption of electric energy is detected. The Review of Judicial Practice on Disputes on Payment for Unaccounted Consumption of Water, Heat and Electricity Supplied via the Connected Grid, approved by the Presidium of the Supreme Court of the Russian Federation on December 22, 2021, was analyzed, namely, the possibility of its application by antimonopoly authorities as part of the consideration of cases of abuse of position, an analysis of the practice of applying this review at the present time was carried out. At the end, it was concluded that this review partly determined the necessary changes to the legislation on the electric power industry.
Image guided fine needle aspiration cytology of hepatic lesions – Two year study in a Tertiary health care centre, Telangana (Hyderabad)
Authors: Sanjuktha Puli Arun , Korti Padmaja , Shaik Reenaz , Marapaka Pavani , Begum Fakeha 
Published: September 2022

Mass lesions of liver are generally evaluated by Fine needle aspiration (FNA). Aim of present study was to assess the utility of ultrasound guided FNA cytology in the diagnosis of hepatic lesions and to study the cytomorphological features of these lesions and to categorise them as inflammatory, benign and malignantPatients who have been admitted during a period between 2018 to 2021 February with suspected liver diseases were subjected to ultrasound guided FNAC and cytological assessment.Fine needle aspirations of liver were performed on 39 patients. Out of which 26 were suspected by malignant lesions and 13 of non-neoplastic lesions. Of the 39 aspirations performed on patients with suspected malignancy, 26 were diagnosed as positive (66.66%). Among other 13 non- neoplastic lesions only 6 were diagnosed positive under cytological examination by FNAC (46.15%). This could be due to more yield of material in malignant lesions than non-neoplastic lesions of liver and technical expertise of FNAIn most of the cases Cytomorphological study of Hepatic masses by fine needle aspiration yields an accurate diagnosis but in some cases correlation with other investigations and ancillary studies are required for definitive diagnosis.
Rhabdoid tumor of cheek in an adult patient: A rare case report
Authors: Verma Priyanka , Zaidi Noorin , Irfan De. Sumaiya , Zehra Andleeb , Lal Nirupma 
Published: September 2022

Rhabdoid tumor is relatively rare highly malignant tumor in adult older than 40 years, therefore treatment regimens often throwing from pediatric age group. It is characterized by extremely aggressive behavior, rapid metastasis to other organ, low survival rate and no targeted therapy. So, early diagnosis is necessary for better treatment and reduce mortality outcome. A 42 years male suffering from a right side cheek mass of 5x3cm associated with tongue displacement to left side and difficulty in swallowing. After complete removal of lesion for histopathological examination, revealed grossly the tumor is well defined gray-white, round, lobulated 5x3cm in size having infiltrating borders. Cut surface shows gray-white to gray-brown, solid areas. Microscopically H&E stained section revealed, sheets of tightly packed large, discohesive, polygonal cells having abundant eosinophilic cytoplasm with eccentrically placed round nuclei showing distinct prominent vesicular nucleoli separated by thin fibrous septae with blood vessels. These cells lie in myxoid background. These tumor cells have deeply acidophilic having finely granular abundant cytoplasm with small, peripherally placed nuclei and abundant intra-cytoplasmic vacuoles along with nuclear pleomorphic, no mitotic figure seen. Histologically, the adult type tumor proliferating as sheet of tightly packed large, discohesive, polygonal cells having abundant eosinophilic cytoplasm with eccentrically placed round nuclei showing distinct prominent vesicular nucleoli separated by thin fibrous septae with blood vessels lie in fibromyxoid background. These tumor cells have deeply acidophilic, finely granular cytoplasm with small, peripherally placed nuclei with occasional intra-cytoplasmic vacuoles along with cross striations, no mitotic figures seen. Study concludes that adult type Rhabdoid tumors have extremely aggressive behavior, rapid metastasis spread to other organs, low survival rate and no targeted therapy. Usually males older than 40years of age are affected. It is crucial to make a rapid correct diagnosis and early treatment may improve the outcome.
Renal replacement lipomatosis with granulomatous inflammation – A case report and review of literature
Authors: R Veena , B M Sowmya , Prabhu Gowri , Kulkarni Varendra G 
Published: September 2022

Renal replacement lipomatosis can be defined as the proliferation of fibrofatty tissue which subsequently replace the renal parenchyma. It is usually benign unilateral and occurs as a result of severe atrophy or destruction of the renal parenchyma, due to a calculus with secondary proliferation of renal sinus, renal hilus, and perirenal fatty tissue to a variable extent.A 55yr old female presented to surgeon with history ofpain and swelling in right flank. On CECT abdomen there was seen non functional right kidney with staghorn calculi along with perirenal abscess. Patient was treated with nephrectomy and drainage of collection. Intraoperatively Perirenal Abscess extending to psoas and iliopsoas region along with dense adhesion between kidney and liver was found. The multiple sections studied from the lesion showed extensive fibrofatty tissue with few tubule like structures lined by cuboidal epithelium and containing dense eosinophilic secretions. There is seen mixed inflammatory infiltrates with granulomas. Histological features confirmed that Renal replacement lipomatosis with granulomatous inflammation.The clinical importance of RRL is that it stimulates fat-containing tumors in the kidney or its vicinity such as lipomas, angiomyolipomas and liposarcomas can be misdiagnosed preoperatively. Hence this case report has been presented to create awareness of this condition among the pathologist and practicing urosurgeons.
Badania kliniczne na rzecz dobra pacjenta i gospodarki
Authors: Paplicki Mateusz 
Published: September 2022

Celem artykułu jest ustalenie, czy badania kliniczne przyczyniają się do poprawy dobrostanu zdrowotnego pacjentów oraz przynoszą wartość dodaną gospodarce. Ważnym zadaniem było również wykazanie, że bez badań klinicznych nie będzie rozwoju medycyny, a tym samym nowych skutecznych terapii wydłużających życie pacjentów i podnoszących jakość ich życia. Osiągnięcie założonego celu wymagało przeprowadzenia analizy literatury, piśmiennictwa oraz regulacji prawnych dotyczących badań klinicznych w kontekście korzyści, jakie te badania mogą przynieść pacjentowi i gospodarce.
Badania kliniczne są nieodzownym elementem procesu powstawania nowych leków. Wszystkie nowe leki muszą bowiem zostać przebadane w trakcie badań klinicznych pod kątem skuteczności i bezpieczeństwa, zanim zostaną podane pacjentom. Badania kliniczne są niezbędne, aby producent mógł zarejestrować nowy lek i wprowadzić go na rynek, tym samym są one fundamentem współczesnej medycyny i warunkiem dostępu pacjentów do nowoczesnych terapii oraz znacząco wpływają na poszerzenie zawodowej wiedzy lekarzy.
W ciągu ostatnich lat liczba prowadzonych w Polsce badań klinicznych znacząco wzrosła, ale na pewno nie jest to szczyt możliwości tego rynku. Sektor farmaceutyczny to przy tym jedna z najszybciej rozwijających się branż nie tylko w Polsce, lecz także na całym świecie. W Polsce przemysł farmaceutyczny stanowi 1% PKB, co czyni go największym rynkiem w Europie Środkowo-Wschodniej i szóstym co do wielkości w Unii Europejskiej.
Zaobserwowany wzrost wynika przede wszystkim ze stopniowego znoszenia barier, które przez lata hamowały rozwój rynku badań klinicznych. Niestety wciąż istnieją liczne ograniczenia natury prawnej i organizacyjnej, których zniesienie lub zmiana pozwoliłyby rynkowi prężniej się rozwijać. Ograniczenia te występują na rynku zarówno krajowym, jak i Unii Europejskiej. Z tego powodu i polskie organy administracji rządowej, i instytucje europejskie podejmują wysiłki, aby badania kliniczne w coraz większym stopniu przynosiły pożytek zarówno pacjentom, jak i gospodarkom krajów, w których są prowadzone.
Decyzje Prezesa UOKiK w sprawach zmów przetargowych
Authors: Brzezińska-Rawa Anna 
Published: September 2022

Przedmiotem zainteresowania autorki w niniejszym opracowaniu są decyzje Prezesa UOKiK. W tekście dokonano analizy z zakresu porozumień ograniczających konkurencję w postaci zmowy przetargowej z ostatnich dziesięciu lat. W tym czasie Prezes UOKiK wydał 75 decyzji z tego zakresu. Od tych decyzji w 32 przypadkach złożono odwołanie; w 64 decyzjach nałożono karę pieniężną, a w przypadku pozostałych 11 decyzji postępowanie umorzono albo odstąpiono od wymierzenia kary.
W artykule przeanalizowano kwestię oceny szkodliwości zmów przetargowych przez Prezesa UOKiK, zaistniałe formy zmów przetargowych i dowody świadczące o ich zawarciu, a ponadto przypadki odstąpienia od wymierzenia kary ze względu na precedensowy charakter sprawy. W swoich decyzjach Prezes UOKiK nie miał wątpliwości co do szkodliwości zmów przetargowych i naruszenia interesu publicznego w wypadkach, gdy zmowy te zostały zawarte. Licznie wykrywane były zmowy, które polegały na uzgodnieniu warunków składanych ofert, a także zmowy, w których działania przedsiębiorców zakładały rozstawianie i wycofywanie ofert. W analizowanych decyzjach Prezes UOKiK konsekwentnie formułował i podtrzymywał tezę o trudnościach dowodowych w wypadku praktyk uzgodnionych, gdy nie doszło do zawarcia umowy cywilnoprawnej między uczestnikami porozumienia.
Interwencjonizm państwa członkowskiego Unii Europejskiej w gospodarce
Authors: Kosikowski Cezary 
Published: September 2022

Do sytuacji państwa członkowskiego Unii Europejskiej odnoszą się równocześnie wszystkie trzy rodzaje współczesnego interwencjonizmu w gospodarce (międzynarodowy, unijny i państwowy). Pozostają one w związku współistnienia i zależności oraz się uzupełniają. Interwencjonizm międzynarodowy i unijny nie pozbawiają racji bytu interwencjonizmu krajowego wykonywanego przez państwa członkowskie UE. Jest to jednak interwencjonizm inny niż tradycyjny interwencjonizm państwowy z XIX i pierwszej połowy XX wieku.
Zadaniem współczesnego państwa jest bowiem osiągnięcie poziomu cywilizacyjnego rozwiniętych państw. Dlatego jego obowiązkiem powinno być dążenie do uzyskania członkostwa w najważniejszych organizacjach międzynarodowych i integracyjnych oraz ratyfikowanie innych, ważnych z punktu widzenia społeczeństwa i gospodarki, umów międzynarodowych. Dzięki temu społeczeństwo danego państwa może liczyć na to, że jego władze krajowe sięgną po nowoczesne wzorce i standardy rozwoju cywilizacyjnego. Obecnie dotyczą one nie tyle samej gospodarki i jej mechanizmów, ile szeroko rozumianego bezpieczeństwa (klimatycznego, energetycznego, zdrowotnego, demograficznego czy socjalnego). Bezpieczeństwo ma gwarantować właściwa polityka społeczna i gospodarcza państwa. Współczesny interwencjonizm państwowy polega zatem na wdrażaniu do prawa i praktyki krajowej standardów rozwiązań ustalonych w ramach prawa interwencjonizmu międzynarodowego i unijnego. Wiąże się też z koniecznością uzupełniania pewnych rozwiązań w drodze regulacji krajowych, o ile zezwalają na to przepisy prawa międzynarodowego i unijnego.
ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4A
Authors: zhao shu , wang Jian , wu baitong , yang danjing , wang guangming , xiu Guanghui , ling bing , wen yi , li huimin , du dajiang , xu jun 
Published: September 2022

AbstractBackground:Osteoarthritis (OA) is a highly degenerative joint disease, mainly companying with progressive destruction of articular cartilage. Adipose-derived stromal cells (ADSCs) therapy enhances articular cartilage repair, extracellular matrix (ECM) synthesis and attenuates joints inflammation, but specific mechanisms of therapeutic benefit remain poorly understood. This study aimed to clarify the therapeutic effects and mechanisms of ADSCs on cartilage damage in keen joint of OA rat model.Methods:In vivo study, destabilization of the medial meniscus (DMM) and anterior cruciate ligament transection (ACLT) surgery-induced OA rats were treated with allogeneic ADSCs by intra-articular injections for 6 weeks. The protective effect of ADSCs in vivo was measured using Safranin O and fast green staining, immunofluorescence and western blot analysis. Meanwhile, the miRNA-7-5p (miR-7-5p) expression was assessed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The mechanism of increased autophagy with ADSCs addition through decreasing miR-7-5p was revealed using oligonucleotides, adenovirus in rat chondrocytes. The luciferase reporter assay were used to reveal the molecular role of miR-7-5p and autophagy related 4A (ATG4A). The substrate of mTORC1 pathway: (p-)p70S6 and (p-)S6 in OA models with ADSCs addition were detected by western blotting.Results:The ADSCs treatment repaired the articular cartilage and maintained chondrocytes ECM homeostasis through modulating chondrocytes autophagy in OA model, indicators of the change of autophagic proteins expression and autophagic flux. Meanwhile, the increased autophagy induced by ADSCs treatment was closely related to the decreased expression of host-derived miR-7-5p, negative modulator of OA progression. Functional genomics (overexpression of genes) in vitro studies demonstrates inhibition of host-derived miR-7-5p in mediating the benefit of ADSCs administration in OA model. Then ATG4A were defined as a target gene of miR-7-5p, and the negative relation between miR-7-5p and ATG4A were investigated in OA model treated with ADSCs. Furthermore, miR-7-5p mediated chondrocyte autophagy by targeting ATG4A in OA cell model treated with ADSCs was confirmed with the rescue trial of ATG4A/miR-7-5p overexpression on rat chondrocyte. Finally, the mTORC1 signaling pathways mediated by host-derived miR-7-5p with ADSCs treatment were decreased in OA rats.Conclusions:ADSCs promotes the chondrocytes autophagy through decreasing miR-7-5p in articular cartilage by targeting ATG4A and a potential role for ADSCs based therapeutics for prevention of articular cartilage destruction and extracellular matrix (ECM) degradation in OA.