bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of long‐term medication adherence in stroke survivors: A multicentre, prospective, longitudinal study
Authors: Yoo Sung‐Hee , Kim Gye‐Gyoung , Kim Sung Reul , Park Man‐Seok , Kim Joon‐Tae , Choi Kang‐Ho , Park Hyun‐Young , Yi Sang‐Hak , Cha Jae‐Kwan , Kim Dae‐Hyun , Nah Hyun‐Wook 
Published: August 2022

AbstractBackgroundAlthough the optimal use of prescribed medications for stroke survivors is critical for preventing secondary stroke, longitudinal observations of the natural course of medication persistence and adherence in Korean stroke survivors are rare. Furthermore, studies are needed to identify strong predictors influencing medication adherence and to determine whether these predictors change over time.Aims and objectivesTo evaluate the longitudinal medication persistence and adherence at 3 months and 1 year after discharge in all stroke patients and to identify predictors of long‐term medication adherence in patients who can self‐medicate.DesignA multicentre, prospective, longitudinal descriptive study.MethodsA total of 600 consecutive ischaemic stroke patients were recruited from three stroke centres across Korea, from 1 September, 2017 to 28 February, 2019. Various factors related to medication adherence suggested by the World Health Organisation were investigated through face‐to‐face interviews at each centre during hospitalisation. Medication persistence and adherence were assessed at 3 months and 1 year after discharge using the eight‐item Morisky Medication Adherence Scale through telephone interviews.ResultsOf 537 survivors at 3 months, 526 (98.0%) were persistent and 472 (89.7%) were adherent. Of 493 survivors at 1 year, 477 (96.8%) were persistent and 392 (82.2%) were adherent. Medication belief, income and health literacy were statistically significant predictors of three‐month medication adherence, which predicted one‐year medication adherence with older age and low income.ConclusionsAmong Korean stroke survivors, three‐month and one‐year medication persistence and adherence were relatively good. Medication beliefs and three‐month medication adherence were important and modifiable factors predicting three‐month adherence and one‐year adherence, respectively.Relevance to clinical practiceTo increase long‐term adherence to medication, various strategies are needed to improve beliefs about medication, taking into account the patient's age and level of knowledge. These interventions need to be initiated during hospitalisation to form early medication habits after discharge.
Developmental outcomes in Japanese preschool‐age children conceived through assisted reproductive technology
Authors: Aoki Sayaka , Hashimoto Keiji , Ogawa Kohei , Horikawa Reiko , Sago Haruhiko 
Published: August 2022

AbstractAimThis study aimed to investigate the developmental outcomes of Japanese babies conceived through assisted reproductive technology (ART), born at ages 48 and 60 months.MethodsData were collected from 725 children in a hospital‐based cohort study conducted in Japan. The children's level of development was assessed using the Kinder Infant Development Scale, a parent‐rated questionnaire that consists of nine developmental domains. We compared the development between children conceived through ART (N = 189) and those conceived naturally (N = 536) by conducting analyses of covariance. For the analyses, we controlled for the effects of maternal age, family income, parental education, and multiple births.ResultsAt 48 months, no significant difference was found between children conceived through ART and those conceived naturally, except for the development of receptive language (F(1, 718) = 4.869, p = 0.028)), which was found only for boys. The mean developmental age of receptive language was 60.1 for the children conceived through ART and 57.5 for those conceived naturally. At 60 months, no significant difference was found between children conceived through ART and those conceived naturally, in all domains.ConclusionAt ages 48 and 60 months, no significant difference was found between the children conceived through ART and those conceived naturally in nine developmental domains, except for boys' receptive language at 48 months.
Pregnancy outcomes after preterm premature rupture of membranes: The Japan Environment and Children's Study
Authors: Hirata Katsuya , Ueda Kimiko , Wada Kazuko , Ikehara Satoyo , Tanigawa Kanami , Kimura Tadashi , Ozono Keiichi , Iso Hiroyasu ,   the Japan Environment and Children's Study Group
Published: August 2022

AbstractAimTo evaluate the pregnancy outcomes of preterm premature rupture of membranes (preterm PROM; PPROM) by gestational age.MethodsThis cohort study analyzed data from the Japan Environment and Children's Study. Pregnancy outcomes were documented using descriptive statistics. Logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of complications.ResultsData were collected for 104 062 fetuses, and 99 776 were eligible for inclusion. The incidences of early (18–23 weeks) and late (24–36 weeks) PPROM were 0.1% (n = 102) and 1.2% (n = 1205), respectively. Of the 1307 cases, 66 (5.0%) resulted in miscarriage or stillbirth. Overall, 85.6% (1119/1307) resulted in preterm births, and 9.3% (122/1307) in term births. There was a higher incidence of oligohydramnios (OR 6.82, 95% CI 4.07, 11.4; OR 2.42, 95% CI 1.72, 3.40), intrauterine infection (OR 11.9, 95% CI 7.06, 19.9; OR 4.39, 95% CI 3.01, 6.41), cesarean delivery (OR 3.31, 95% CI 2.32, 4.71; OR 1.34, 95% CI 0.97, 1.85), placental abruption (OR 5.57, 95% CI 2.30, 13.5; OR 5.40, 95% CI 3.58, 8.14), and 5‐min Apgar score <7 (OR 35.3, 95% CI 21.5, 57.9; OR 2.66, 95% CI 1.75, 4.05) for early and late, compared to no, PPROM, respectively. Miscarriage or stillbirth was higher in early (OR 5.84, 95% CI 3.72, 9.15) and lower in late (OR 0.21, 95% CI 0.06, 0.68) compared to those without PPROM.ConclusionsThis study described the epidemiology of pregnancy outcomes of early (occurring at the limit of viability) and late PPROM.
The prevalence of and potential risk factors for Developmental Language Disorder at 10 years in the Raine Study
Authors: Calder Samuel D , Brennan‐Jones Christopher G. , Robinson Monique , Whitehouse Andrew , Hill Elizabeth 
Published: August 2022

AimThis study sought to determine the prevalence of Developmental Language Disorder (DLD) in Australian school‐aged children and associated potential risk factors for DLD at 10 years.MethodsThis study used a cross‐sectional design to estimate the prevalence of DLD in Generation 2 of the prospective Raine Study. Participants included 1626 children aged 10 years with available language data. Primary outcomes included variables matching diagnostic criteria for DLD. Associations of other potential prenatal and environmental variables were analysed as secondary outcomes.ResultsThe prevalence of DLD in this sample was 6.4% (n = 104) at 10 years. This sub‐cohort comprised 33.7% (n = 35) with expressive language deficits, 20.2% (n = 21) with receptive language deficits, and 46.2% (n = 48) with receptive‐expressive deficits. No significant difference in sex distribution was observed (52.9% male, p = 0.799). Children who were exposed to smoke in utero at 18 weeks gestation were at increased risk of DLD at 10 years (OR = 2.56, CI = 1.23–5.35, p = 0.012).ConclusionsDLD is a relatively prevalent condition in Australian children, even when assessed in middle childhood years. These findings can inform future research priorities, and public health and educational policy which account for the associations with potential risk factors.
Traditional intellectual properties and Yoruba (Ifa) philosophy in South‐West Nigeria: Intellectual property versus traditional protection approach
Authors: Lawal‐Arowolo Ayoyemi , Taiwo Ademola 
Published: August 2022

AbstractThe claim that Ifa is not merely a form of worship has been made by many scholars and remains a controversy. According to them, it is the core of Yoruba philosophy and scientific as well. Nevertheless, there exists art and science of an intellectual orientation regarding the development of Yoruba people. There are artworks, sculptures, incantations (poetry), and performances in Ifa. Divination is based on the binary system linked to science, as well as the process of traditional healing. Indeed, where you have art and science, intellectual property rights (IPRs) are in pursuit. In this case, copyright, patents, and trade secrets. The aim of this article is to examine IPRs in the spiritual world of Ifa and Yoruba philosophy; proposing that spiritual intellectual properties are for an entirely different world with a protection mechanism outside the modern approach of protection, while other forms of traditional intellectual properties outside the realm of the spiritual world requires modern intellectual property protection approach, subsequent to the understanding of the creator or inventor.
Relational legal consciousness and anticorruption: Lava Jato, social media interactions, and the co-production of law's detraction in Brazil (2017–2019)
Authors: de Sa e Silva Fabio 
Published: August 2022

AbstractStarting in 2014, Brazilian politics was shaken up by the lava jato (LJ) operation, a law-centered anticorruption initiative. LJ unveiled a large corruption scheme in Brazil's national oil company Petrobras, which involved Petrobras directors, political party officials, and large construction companies. LJ was both disruptive and contentious. To some, it started a new chapter in Brazilian history, marked by greater respect for the “rule of law” and a collective “state of mind” concerned with “ending impunity” and building integrity in politics and businesses. To others, it contributed to undermining democracy and the rule of law, paving the way for an autocratic leader—the current Brazilian president Jair Bolsonaro. This article sheds further light on those discussions by looking at LJ as a site of “legal consciousness” production. Empirically, the article focuses on conversations generated by lead LJ prosecutors on a major social media platform (Facebook) from 2017 to 2019. Considering this body of data, the article addresses the question: “When prosecutors and ‘the people’ talked about LJ, what did they talk about?” My findings support the more skeptical views of the operation. The exchanges between LJ prosecutors and their Facebook followers supported the co-production of a cultural schema averse to the “rule of law.” These findings have implications for both legal consciousness and anticorruption research.
Procedural justice for all? Legitimacy, just culture and legal anxiety in European civil aviation
Authors: Woodlock John 
Published: August 2022

AbstractThis article presents the results of survey-based research which explores if licensed aircraft maintenance engineers working in Norway, Sweden, and Portugal experience regulated “just culture” as procedural justice-infused processes when occurrence reporting in European Union (EU) civil aviation. Drawing on Tylerian procedural justice theory, the study finds that, perceived procedural justice is more strongly associated with legitimacy (perceived as support for rules and authority) than legal anxiety among the maintenance engineers. Country-based results reveal differences in engineers' legal experiences of occurrence reporting with perceived procedural justice strongest in Sweden and legal anxiety most influential in Portugal. The article contributes with a first exploration of “just culture” as a procedural justice-infused legal intervention to improve compliance to regulated occurrence reporting by negating legal anxiety in a European aviation context.
Preferential catabolism of l‐ vs d‐serine by Proteus mirabilis contributes to pathogenesis and catheter‐associated urinary tract infection
Authors: Brauer Aimee L. , Learman Brian S. , Taddei Steven M. , Deka Namrata , Hunt Benjamin C. , Armbruster Chelsie E. 
Published: August 2022

AbstractProteus mirabilis is a common cause of urinary tract infection, especially in catheterized individuals. Amino acids are the predominant nutrient for bacteria during growth in urine, and our prior studies identified several amino acid import and catabolism genes as fitness factors for P. mirabilis catheter‐associated urinary tract infection (CAUTI), particularly those for d‐ and l‐serine. In this study, we sought to determine the hierarchy of amino acid utilization by P. mirabilis and to examine the relative importance of d‐ vs l‐serine catabolism for critical steps in CAUTI development and progression. Herein, we show that P. mirabilis preferentially catabolizes l‐serine during growth in human urine, followed by d‐serine, threonine, tyrosine, glutamine, tryptophan, and phenylalanine. Independently disrupting catabolism of either d‐ or l‐serine has minimal impact on in vitro phenotypes while completely disrupting both pathways decreases motility, biofilm formation, and fitness due to perturbation of membrane potential and cell wall biosynthesis. In a mouse model of CAUTI, loss of either serine catabolism system decreased fitness, but disrupting l‐serine catabolism caused a greater fitness defect than disrupting d‐serine catabolism. We, therefore, conclude that the hierarchical utilization of amino acids may be a critical component of P. mirabilis colonization and pathogenesis within the urinary tract.
Medium‐chain fatty acid esters are effective even in azole‐resistant Malassezia pachydermatis
Authors: Koch Christin , Nordzieke Steffen , Grieger Jessica , Mayser Peter 
Published: August 2022

AbstractBackgroundMalassezia (M.) pachydermatis as a frequent reason for dermatological consultation in dogs and cats was recently shown to be lipid‐dependent, too. Lipolytic activity is a prerequisite for activating antimicrobial effectivity of fatty acid esters.ObjectivesIt was therefore of interest whether it is possible to induce this mechanism in M. pachydermatis and to identify possible differences between minimal and strong lipid‐dependent strains.MethodsIn an agar dilution test, the minimal inhibitory concentrations of six fatty acid esters were determined for seventeen M. pachydermatis strains. GC analysis of parent compounds and liberated fatty acids was used to quantify ester cleavage.ResultsHydrolysis was observed in all test strains in a homogenous manner but was dependent on the chemical structure. Lowest MICs (500 ppm after 14 days of incubation) were obtained applying glyceryl monocaprylate and 3‐hydroxylpropyl caprylate, while the corresponding esters of undecylenic acid showed nearly twice the value. As shown by GC analysis with the reference strains CBS 1879 and CBS 1892 and 3‐hydroxypropyl caprylate, hydrolysis and caprylic acid formation starts immediately and was dependent on yeast density. Furthermore, nine azole‐resistant strains isolated from dogs with treatment failures showed MIC values comparable to the other strains and no resistance to monohydric fatty acid esters.ConclusionsMedium‐chain fatty acid esters may represent a new therapeutic option for veterinary use even in azole‐resistant strains. The in vivo verification in M. pachydermatis‐associated dermatitis in dogs and cats will be the next step for the successful development of new therapeutics.
Dancing with the Stars: Does Playing in Elite Tournaments Affect Performance?
Authors: Güner İlhan , Hamidi Sahneh Mehdi 
Published: August 2022

AbstractThis article documents spillover effects using participation in an elite international football tournament as a laboratory. Using a novel dataset from top 5 European football leagues, we find that participation in highly selective UEFA Champions League (UCL) generates large performance gains to participating teams in their domestic leagues. More precisely, UCL participation improves goal difference (goals scored minus goals conceded) by approximately 0.3 goals per game and probability margin (probability of winning minus probability of losing) by approximately 10 percentage points. By investigating causal channels through which participation in the UCL might affect performance, we argue that our results suggest the importance of spillover effects in sports.
Attitudes of optometrists towards artificial intelligence for the diagnosis of retinal disease: A cross‐sectional mail‐out survey
Authors: Ho Sharon , Doig Gordon S. , Ly Angelica 
Published: August 2022

AbstractPurposeArtificial intelligence (AI)‐based systems have demonstrated great potential in improving the diagnostic accuracy of retinal disease but are yet to achieve widespread acceptance in routine clinical practice. Clinician attitudes are known to influence implementation. Therefore, this study aimed to identify optometrists' attitudes towards the use of AI to assist in diagnosing retinal disease.MethodsA paper‐based survey was designed to assess general attitudes towards AI in diagnosing retinal disease and motivators/barriers for future use. Two clinical scenarios for using AI were evaluated: (1) at the point of care to obtain a diagnostic recommendation, versus (2) after the consultation to provide a second opinion. Relationships between participant characteristics and attitudes towards AI were explored. The survey was mailed to 252 randomly selected practising optometrists across Australia, with repeat mail‐outs to non‐respondents.ResultsThe response rate was 53% (133/252). Respondents' mean (SD) age was 42.7 (13.3) years, and 44.4% (59/133) identified as female, whilst 1.5% (2/133) identified as gender diverse. The mean number of years practising in primary eye care was 18.8 (13.2) years with 64.7% (86/133) working in an independently owned practice.On average, responding optometrists reported positive attitudes (mean score 4.0 out of 5, SD 0.8) towards using AI as a tool to aid the diagnosis of retinal disease, and would be more likely to use AI if it is proven to increase patient access to healthcare (mean score 4.4 out of 5, SD 0.6). Furthermore, optometrists expressed a statistically significant preference for using AI after the consultation to provide a second opinion rather than during the consultation, at the point‐of‐care (+0.12, p = 0.01).ConclusionsOptometrists have positive attitudes towards the future use of AI as an aid to diagnose retinal disease. Understanding clinician attitudes and preferences for using AI may help maximise its clinical potential and ensure its successful translation into practice.
Feasibility of Computer‐Aided Design in Limb Lengthening Surgery: Surgical Simulation and Guide Plates
Authors: Cheng Kai , Peng Yuanhao , Yan Xiaonan , Wen Xinghua , Ding Huanwen 
Published: August 2022

ObjectiveTo evaluate the feasibility and utility of computer‐aided design (CAD) in surgical treatment of leg length discrepancy (LLD) using monorail external fixators.MethodsIn the present case series, we retrospectively analyzed seven patients diagnosed with LLD who were surgically treated using a monorail external fixator between June 2018 and August 2020. A personalized surgical emulation of each patient was designed using CAD based on preoperative CT scans to measure limb parameters. Through reverse engineering, a surgical guide plate was then designed to assist with correcting the limb deformity. Patient general information and clinical history, leg length, mechanical lateral distal femoral angle (mLDFA), anatomical anterior distal tibial angle (aADTA), and surgical parameters were recorded during the perioperative period. Three months after external fixator removal, distraction‐consolidation time (DCT), healing index (HI), and lower extremity function score (LEFS) were calculated, and statistically analyzed by paired T‐test.ResultsThe mean limb lengthening achieved was 6.41 ± 2.54 (range, 3.30–10.54) cm with either varus or valgus correction. The mean operative duration was 151 ± 41.87 (84–217) minutes and mean blood loss was 53.58 ± 22.51(25–87) ml. The mean distraction‐consolidation time was 3.67 ± 1.13 (range, 2.5–6.0) months and mean external fixator duration was 11 ± 2.45 (range, 8–14) months. The mean healing index (HI) was 18.11 ± 3.58 (range, 12.8–22.7) days/cm. Mean LEFS scores improved postoperatively from 32.17 8.57 (range, 24–45) to 61.17 6.68 (range, 50–67) with a significant difference (T = –14.26,P < 0.001).ConclusionsSimultaneous length and angular correction can be achieved by incorporating CAD into the surgical treatment of patients with LLD, without compromising postoperative lower limb function. CAD demonstrates utility in the surgical treatment of LLD by improving the functionality of monorail external fixators.
The Confucian Ren and Care Debate: Reassessment, Development, and Future Directions
Authors: Li Chenyang 
Published: August 2022

AbstractIt has been three decades since comparative philosophers began to associate the Confucian concept of ren 仁 with contemporary Western care ethics. It would be useful to revisit the issue and to reassess related debates. In this essay, I first contextualize this discourse by tracing the emergence of care as a philosophical concept in the West and explicate the Confucian concept of ren in terms of care as it is formulated in classic texts. Then I respond to challenges, including opposing views from influential care ethicists Nel Noddings and Virginia Held. I also discuss some promising studies to further this discourse.
Sinus augmentation procedure via the lateral window technique—Reducing invasiveness and preventing complications: A narrative review
Authors: Valentini Pascal , Artzi Zvi 
Published: August 2022

AbstractSinus augmentation has become an integrated surgical phase in posterior maxillary implant prosthesis reconstruction. Since the residual alveolar bony height usually requires additional volume particularly at this anatomical region, sinus floor augmentation is advocated routinely. Over the years, Implant success rate is proved to be comparable to the one in the pristine bone, which is well documented in the literature. Anatomical aspects as well as surgeon skills are at most importance to achieve predictable outcome. In this narrative review, the different osteotomy techniques, the indications toward 1 or 2‐stage approaches, the control of the Schneiderian membrane integrity as well as the management of intra‐ and post‐operative complications are thoroughly discussed according the current data. In light of the excellent long‐term implant success rate concurrent with the application of contemporary advanced techniques of the sinus augmentation via the lateral wall osteotomy approach, reduce invasiveness and less complication occurrences are well documented. A well‐codified patient selection involving the rhinologist as an integral medical team would be significantly beneficial toward early diagnosis. In‐depth knowledge of the anatomy, execution of a well standardized surgical technique, and understanding the complication etiology and their management are prerequisites for reducing patient morbidity to minimal discomfort and predictable successful outcome.
One size may not fit all: Financial fragmentation and European monetary policies
Authors: Gagnon Marie‐Hélène , Gimet Céline 
Published: August 2022

AbstractThis article investigates the impact of European Central Bank policies on credits considering financial and banking fragmentation. Using European data from the past decade, we estimate SVAR models to analyze the regional impact of conventional and unconventional measures on price and volume indicators of fragmentation. The risk‐taking channel is studied using GVAR models to document the national consequences of this fragmentation. We find that unconventional measures increase credit in peripheral countries. Monetary policies alleviate fragmentation, but mostly in terms of price dispersion rather than credit volume. Finally, unconventional measures imply a rebalancing of European bank assets in favor of foreign currency denominated‐assets.