bluuebunny/crossref_metadata_2025_split huggingface dataset:
Grain sizes and minerals in sediments of Gulf of Tonkin, Viet Nam
Authors: Nhon Dang Hoai , Thao Nguyen Van , Thanh Tran Duc , Ve Nguyen Dac , Vuong Bui Van , Thuy Lai Thi Bich , Loan Bui Thi Thanh , Chien Hoang Thi , Nghi Duong Thanh 
Published: June 2022

Abstract

Grain sizes and minerals of sediments in the Gulf of Tonkin were assessed by thirty surface samples and fifty samples in two sediment cores, in which sieve and pipette methods as well as X-ray diffraction were utilized for analyzing grain sizes and minerals, respectively. The studied results show that there were five sediment types, including fine sand, very fine sand, very coarse silt, coarse silt and medium silt. Fine sand was from moderately to poorly sorted and from symmetrical to very coarse skewed. Very fine sand was from moderately to very poorly sorted and from very fine to symmetrical skewed. Very coarse silt was poorly sorted and very fine skewed. Coarse silt was poorly to very poorly sorted and fine to very fine skewed. Medium silt was very poorly sorted and from fine to very fine skewed. Mineral abundance in sediments was identified by quartz, illite, kaolinite, feldspar, chlorite, goethite, calcite, aragonite, illite and montmorillonite. Additionally, the quartz, illite, kaolinite, feldspar, chlorite, montmorillonite in sediments reflected sediment supplies from weathering, erosion from mainland and islands, flow of rivers and ocean processes. Goethite and gibbsite, halite originated from chemical processes while calcite and aragonite originated from biological material.
CBMODPSO: Crossover based multi-objective discrete particle swarm optimization for solving multi-modal routing problem
Authors: Afrasyabi Parastoo , Mesgari Mohammad Saadi , Khodadai Nima , Kaveh Mehrdad 
Published: June 2022

Abstract
Nowadays, in complicated urban structures, passengers have to use a set of modes and vehicles to reach their destination. In these circumstances, choosing an optimal route in several ways is a complicated optimization problem. The main goal of this study is to solve the routing problem in the urban multi-modal network by developing a suitable multi-objective optimization algorithm. The studied multi-modal network is the transportation network of Tehran metropolis, which includes subway, BRT, taxi, and walking modes. Besides, in order to determine the optimized route, objective functions including route length, traffic, comfort, and safety are assumed. Crossover Based Multi-Objective Discrete Particle Swarm Optimization (CBMODPSO) has been used to solve the problem. CBMODPSO has been improved using mutation and crossover operators. MOABC, MOACO, MOBBO, MOGWO, and NSGA-II algorithms were used to evaluate and compare the results of the developed algorithm. In addition, CBMODPSO results have been compared with previous research results. The improved algorithm is more repeatable than other algorithms. The CBMODPSO algorithm has a faster convergence rate and was able to get to an optimal solution in a fewer generation number and much less time. The CBMODPSO algorithm was implemented in about one thirties of the MOBBO duration. Meanwhile, it has a reproducibility of almost twice the MOGWO algorithm. These results indicate the high performance of the CBMODPSO algorithm for multi-modal transport networks, which is a complex routing problem.
Critical role of Wat1/Pop3 in regulating the TORC1 signalling pathway in fission yeast S. pombe
Authors: Panigrahi Lalita , Anjum Simmi , Ahmed Shakil 
Published: June 2022

Abstract
Background: The target of rapamycin (TOR), a major pathway for the regulation of cell growth and proliferation is conserved from yeast to humans. Fission yeast contains two tor complexes, TORC1 is crucial for cell growth while TORC2 gets activated under stress conditions. Pop3/Wat1, a mammalian Lst8 ortholog is an important component of both TOR complexes and has been implicated in the oxidative stress response pathway. Results: The genetic interaction analysis have revealed a synthetic lethal interaction of wat1 with tor2-287 mutant cells. The co-immunoprecipitation studies revealed a physical interaction of Wat1 with the TORC1 components such as Tor2, Mip1, and Tco89. In addition, the mutant Wat1 protein was unable to interact with these proteins. In the absence of Wat1, the cells arrest at G1 phase with reduced cell size at non-permissive temperature reminiscent of tor2-287 mutant phenotype. Similarly, inactivation of Wat1 results in the failure of TORC1 mediated phosphorylation of Psk1 and Rps602, leading to dysregulation of amino acid permeases and delocalization of Gaf1, a DNA binding transcription factor. Additionally, over-expression of rhb1 suppresses the glycerol and KCl sensitivity of wat1Δ and wat1-17 mutant cells suggesting the suppression of osmotic stress response. Conclusion: We proposed that the Wat1/Pop3 is very critical component of TORC1 complex and hence the inactivation of wat1 impaired the downstream signalling of TORC1 pathway. Considering the roles of mLst8, a mammalian ortholog of Wat1 in the tumor progression, novel therapeutic approaches can be utilized to target Wat1/mLst8 that could impede the tumor progression.
How ten-years of reirradiation for paediatric high-grade glioma can shed light on first line treatment
Authors: Massimino Maura , Vennarini Sabina , Barretta Francesco , Colombo Francesca , Antonelli Manila , Pollo Bianca , Pignoli Emanuele , Pecori Emilia , Alessandro Ombretta , Schiavello Elisabetta , Boschetti Luna , Podda Marta , Puma Nadia , Gattuso Giovanna , Sironi Giovanna , Barzanò Elena , Nigro Olga , Bergamaschi Luca , Chiaravalli Stefano , Luksch Roberto , Meazza Cristina , Spreafico Filippo , Terenziani Monica , Casanova Michela , Ferrari Andrea , Chisari Marco , Pellegrini Chiara , Clerici Carlo Alfredo , Modena Piergiorgio , Biassoni Veronica 
Published: June 2022

Abstract
Purpose. Recurrence incidence for paediatric/adolescent high-grade glioma(HGG) exceeds 80%. Reirradiation(reRT) palliates symptoms and delays further progression. Strategies for reRT are scarce: we retrospectively analysed our series to develop rational future approaches.Methods. We re-evaluated MRI+RT plans of 21 relapsed HGG-patients, accrued 2010-2021, aged under 18 years. All underwent surgery and RT+chemotherapy at diagnosis. Pathologic/molecular re-evaluation allowed classification based on WHO 2021 criteria in 20/21 patients. Survival analyses and association with clinical parameters were performed. Results. Relapse after 1st RT was local in 12(7 marginal), 4 disseminated, 5 local+disseminated. Re-RT obtained 8 SD, 1 PR, 1PsPD, 1 mixed response, 10 PD; neurological signs/symptoms improved in 8. Local reRT was given to 12, followed again by 6 local(2 marginal) and 4 local+disseminated second relapses in 10/12 re-evaluated. The 4 with dissemination had 1 whole brain, 2 craniospinal irradiation(CSI), 1 spine reRT and further relapsed with dissemination and local+dissemination in 3/four assessed. Five local+disseminated tumours had 3 CSI, 1 spine reRT, further progressing locally(2), disseminated(1), n.a.(1). Three had a third RT; three were alive at 19.4, 29, 50.3 months after diagnosis. Median times to progression/survival after re-RT were 3.7 months (0.6-16.2 months)/6.9 months (0.6-17.9 months), improved for longer interval r between 1st RT and re-RT(P=0.017) and for non-PD after reRT(P< 0.001). First marginal relapse showed potential association with dissemination after re-RT(P= 0.081) Conclusions. This is the biggest series of re-RT in paediatric HGG. Considering the dissemination relapse incidence observed, our results could prompt the investigation of first RT fields in a randomized trial.
Joint Scheduling Algorithm of Routing and GCL Based on Tabu Search
Authors: Wang Ying , Cheng Yufan , Yu Peng 
Published: June 2022

Abstract
Time sensitive networking (TSN) has been widely adopted and applied in many fields such as industrial Internet and mobile front haul. The scheduling problem of time sensitive networking (TSN) requires that the gate control list(GCL) is calculated according to the flow information in a given topology network, and then the end-to-end scheduling of flow in a specified time is realized. Conventional flow scheduling schemes are usually based on the given routing scheme rather than the overall algorithm decision, which limits the scheduling performance. In this paper, a routing scheduling algorithm based on tabu search is proposed on the basis of a comprehensive routing and GCL scheduling problem model, and the neighborhood movement strategy of routing and scheduling is proposed according to the proposed problem model. Besides, the simultaneous scheduling of both periodic and aperiodic flows is realized. Experimental results show that compared with the solver method, the proposed algorithm can save 75% of the time cost under the acceptable performance compromise in large-scale network scenarios.
SLC22A3 methylation-mediated gene silencing predicts adverse prognosis in acute myeloid leukemia
Authors: Gu Yu , Xu Zi-jun , Zhou Jing-dong , Lin Jiang , Qian Jun , Wen Xiang-mei , Jin Ye , Yuan Qian , Xia Pei-hui , Feng Yuan , Yang Lei 
Published: June 2022

Abstract
Background: We screened out several hypermethylated solute carrier (SLC) family genes in acute myeloid leukemia (AML) by reduced representation bisulfite sequencing (RRBS). SLC22A3 encodes an organic cation transport protein, which is critical for drug transportation and cellular detoxification. SLC22A3 is significantly downregulated and associated with tumor progression and worse prognosis in a variety of solid tumors. However, there are no data available regarding the role of SLC22A in AML. This study aimed to explore the regulatory mechanism of DNA methylation on SLC22A3 expression, as well as its clinical significance in AML prognosis. Results: SLC22A3 was identified as the sole prognosis-associated gene among SLCs based on TCGA and Beat AML databases. Bone marrow mononuclear cells (BMMNCs) from AML, MDS patients and healthy donors were enrolled in this study. SLC22A3 methylation was significantly increased in AML compared with controls and MDS patients, and meanwhile the expression level of SLC22A3 was decreased. SLC22A3 hypermethylation presented obvious association with some specific clinical characteristics and affected survival time of AML patients as an independent risk indicator. SLC22A3 expression changed regularly as the disease complete remissions and relapses. Demethylation drug 5-aza-2’-deoxycytidine (DAC) activated transcription and increased mRNA expression of SLC22A3 in leukemia cell lines and AML fresh BMMNCs. Knockdown of SLC22A3 in leukemia cells enhanced cell proliferation and suppressed cell apoptosis. Data from public programs were used for auxiliary screening of probable molecular mechanisms of SLC22A3 in antileukemia effect. Conclusions: Our results showed that increased methylation and decreased expression of SLC22A3 may be indicators of poor prognosis in AML. Methylation-silenced SLC22A3 expression may have potential guiding significance on anti-leukemia effect of DAC.
Complete response to pembrolizumab in a patient with recurrent and metastatic urothelial bladder carcinoma reflecting coexisting sarcomatoid subtype and glandular differentiation: a case report
Authors: Miyama Yu , Kanao Kent , Uranishi Kousuke , Hirasaki Masataka , Yasuda Masanori 
Published: June 2022

Abstract
Background: In advanced urothelial carcinoma (UC), approximately 20% of patients respond to pembrolizumab, an anti-programmed cell death-1 (PD-1) antibody. Herein, we reported a single case of UC showing coexistence of sarcomatoid subtype and glandular differentiation. Notably, only glandular differentiation was recurrent, probably progressive, and metastatic, which showed complete response to pembrolizumab.Case presentation: An 80-year-old woman presented with hematuria and dysuria, and an intra-vesical tumor was detected on ultrasound. Transurethral resections (TUR) were performed three times. In the first TUR, a sub-pedunculated tumor and a flat lesion were closely but independently located. Pathologically, the sub-pedunculated tumor was an invasive UC, sarcomatoid subtype. Meanwhile, the flat lesion was invasive UC with glandular differentiation. Despite the second and the additional TUR, the tumor was growing and a lymph node metastasis was detected. The third TUR specimen showed UC with glandular differentiation, and a positive PD-L1 expression as well as high density CD8-positive lymphocytic cells infiltration were observed. Pembrolizumab was administered for four courses after terminating the chemotherapy. The CT scan revealed shrinkage of both primary tumor and metastases. Cystectomy and lymph nodes dissection were performed, and no residual carcinoma was detected. The therapeutic effect was regarded as pathological complete response.Conclusions: Pembrolizumab could be effective for special subtype or divergent differentiation of UC, particularly in an event of an ‘immune hot’ tumor.
Flood Susceptibility Mapping of Internally Displaced Persons Camps in Maiduguri, Borno State Nigeria
Authors: Ogunwumi Taiwo , Njoku Chukwudi , Uzoezie Arinze , Benson Iniobong 
Published: June 2022

Abstract
Increasing climate variability is causing an increase in flood occurrence, affecting vulnerable individuals who have been displaced by the insurgency and conflicts that occurred in the past years. The decade-long insurgency in northeast Nigeria is one of the most pressing humanitarian crises on the continent, with over 2 million people displaced from their homes by conflict and political instability. These yearly floods destroy campsites occupied by displaced families who fled from conflict zones. This study applied the multi-criteria approach, Geographical Information System, and Remote Sensing. Analytical processes such as buffering, slope generation, interpolation, reclassification, and the weighted overlay were performed through the GIS environment to generate a flood susceptibility map indicating four zones (very high, high, low and very low-risk). A total number of 25 of 35 Internal displaced campsites are within the high susceptibility while 4 camps are prone to a Very high flood risk level (SULUMBURI DOGON ICHE, GRA, SULUMBURI CAMP, and FULATARI FARIN RUWA). Based on our results, camps located close to water bodies will be submerged by flood during the coming raining seasons if actions are not taken in time. This paper is a vital for appropriate government agencies such as town planners, emergency management agencies, international NGOs, the United Nations Office for the Coordination of Humanitarian Affairs, and other important stakeholders who can implement preparedness, evacuation planning, and early warning to the populace and Internally displaced individual at various campsite and settlement within the inferred flood risk zones.
Exosome s from ADSCs attenuate bleomycin-induced skin fibrosis and oxidative stress in scleroderma via circ-Zfyve9 delivery
Authors: Zhu Zhidong , Tang Hui , Zhu Yiqi , Wang Hao , Shen Yanyun 
Published: June 2022

Abstract
Background
Systemic sclerosis (SSc) is an autoimmune trait affecting several organs and is identified by thickening of the dermis and connective tissue affected by collagen accumulation, as well as vascular injuries inducing hypoxia.
Methods
In this investigation, adipose-derived stem cells (ADSCs) and their exosomes were separated, and a bleomycin-induced SSc mouse model was constructed. High-throughput sequencing was employed to study abnormal expression of circular RNAs (circRNAs) in SSc skin tissues with or without ADSC exosome treatment. The regulatory mechanism and targets were studied using bioinformatics analysis, luciferase reporting analysis, angiogenic differentiation experiments, and RT-qPCR detection analysis.
Results
In this study, exosomes from ADSCs were successfully isolated. In addition, the exosome treatment prevented dermal thickening and fibrosis in bleomycin-induced scleroderma. In addition, circ-Zfyve9 was demonstrated to have an important function in ADSC exosome-mediated skin tissue protection. GPX4 and miR-135 were shown to be circ-Zfyve9 downstream targets. Overexpressing miR-135 or downregulating GPX4 reversed the promotion effects of circ-Zfyve9 to angiopoiesis by increasing lipidosome ROS in EPCs under hypoxic conditions. Overexpressing miR-135 or downregulating GPX4 reversed the inhibition effect of circ-Zfyve9 on fibrosis in myofibroblasts under hypoxic conditions. Overexpressing circ-Zfyve9 increased the therapeutic effect of ADSC exosomes.
Conclusions
Taken together, the present study results show that the exosomes from ADSCs attenuate bleomycin-induced skin fibrosis and oxidative stress in scleroderma via circ-Zfyve9 delivery.
Applications of Choline Chloride-Based Deep Eutectic Solvents as Sustainable Media and Catalyst in the Synthesis of Heterocyclic Scaffolds
Authors: Ratnani Sonia , Bargujar Savita , Khulbe Mihir , Kathuria Abha 
Published: June 2022

Abstract:Deep eutectic solvents (DESs), also referred to as low transition temperature mixtures (LTTMs), have emerged as sustainable and cheap alternatives to conventional organic solvents in organic synthesis. This is attributed to their exceptional characteristics viz. easy preparation with readily available cheap materials, water compatibility, non-flammability, non-toxicity, biocompatibility, biodegradability, etc. All these properties label them as versatile and cost-effective green solvents. The first reported DES, choline chloride urea mixture has appeared as an innocuous solvent and catalyst in many organic transformations. This prospective DES combination has been applied extensively to the synthesis of a wide range of heterocyclic compounds including quinolones, spirooxindoles, etc. The conditions employed are relatively mild and do not require additional acid catalysts or organic solvents. This ecofriendly blend for the synthesis of heterocycles reports excellent yields of products with shorter reaction times and a simple workup procedure. Evaluating these merits, this review focuses on the recent literature published on the use of choline chloride-based DESs in the synthesis of a few important heterocyclic compounds.
A Network Pharmacology Study on the Similarities and Differences in the
Mechanisms of Zuo Gui Wan/You Gui Wan for the Treatment of
Premature Ovarian Failure
Authors: Mei Shanshan , Yu Chaoqin , Ding Jie , Cheng Wen 
Published: June 2022

Background:
Premature ovarian failure is a heterogeneous disease that severely affects the quality of life of women in their reproductive years. The ancient classical Chinese medicine compounds Zuo Gui Wan and You Gui Wan have great potential to treat premature ovarian failure, but the similarities and differences in their pharmacological mechanisms for treating POF are not yet clear.

Method:
In this study, the public database was used to screen the active ingredients and potential targets of Zuo Gui Wan and You Gui Wan. The similarities and differences in the potential targets of both pills for the treatment of POF were analysed using the POF-related genes obtained from OMIM and GeneCards. The protein–protein interaction network was established and collated to form a drug-active ingredient-target gene network by using STRING. Finally, the drug–target–pathway network was constructed by enrichment analysis to find the differences in target enrichment on the same pathway.

Results:
Pharmacological analysis of the network showed that Zuo Gui Wan contains 72 active ingredients, While You Gui Wan has 112. A total of 62 common compositions, such as quercetin and kaempferol, were identified. Amongst them were 10 unique compounds, such as hydroxyproline and cholesterol, in Zuo Gui Wan and 50 exclusive compounds, such as Karanjin and beta-carotene, in You Gui Wan. In addition, 14 overlapping targets, including MAPK1, CXCL8, TNF, IL6, and EGFR, were determined amongst the first 20 targets in the treatment of POF by both pills, demonstrating that the core mechanism of POF treatment is similar between the two. Pathway enrichment analysis showed 87 identical and significant pathways between Zuo Gui Wan and You Gui Wan, including IL-17, TNF, PI3K-Akt, oestrogen, VEGF, and other pathways. Zuo Gui Wan has 12 special pathways, such as natural killer cell-mediated cytotoxicity and intestinal immune network for IgA production. You Gui Wan has nine unique pathways, such as insulin secretion and glucagon signalling pathway.

Conclusion:
Zuo Gui Wan and You Gui Wan could treat POF by inhibiting oxidative stress and inflammation, regulating hormone levels, improving ovarian function, and promoting follicular development. Zuo Gui Wan is inclined to immune regulation, While You Gui Wan prefers insulin regulation. Therefore, similarities and differences clearly exist in the specific mechanisms of Zuo Gui Wan and You Gui Wan in the treatment of POF.
An Insight into the Hepatoprotective Activity and Structure-activity Relationships
of Flavonoids
Authors: Majee Chandana , Mazumder Rupa , Choudhary Alka N. , Salahuddin  
Published: June 2022

Background:
Flavonoids are a class of polyphenolic bioactive compounds obtained from plants, which have a wide range of chemical structures and properties. More than 9000 distinct flavonoid molecules have been identified, and have been found to regulate numerous developmental processes and play key biological roles in living organism.

Objective:
This review aims to highlight the hepatoprotective potentiality of flavonoids and co-relate their pharmacological activity with their chemical structure.

Methods:
With advancement in the field of research related to phytochemicals, it is evident that flavonoids have versatile health benefits, viz., antioxidant property, free radical scavenging capacity, anticancer activity. The basic structures are C6—C3—C6 rings with various substitution patterns, resulting in a succession of subclass compounds, and the relationships between chemical structures and bioactivity have previously been investigated.

Results:
The hepatoprotective effects of bioactive flavonoids derived from plants have been widely linked to their antioxidant activity, antiinflammatory activity, effects on sterol regulatory element-binding proteins (SREBP), peroxisome proliferator-activated receptor gamma (PPARγ) receptors, and inflammatory mediator cytokines according to numerous studies. The C2-C3 double bond at the A ring, as well as the hydroxyl groups of C3′or C4′, and the carbonyl group at position C4,have been shown to augment their hepatoprotective activities; however, hydroxymethylation at C3′ and C4′ has been found to diminish the hepatoprotective activity.

Conclusion:
The impact of flavonoid moieties and the structure-activity relationship of flavonoids related to combating various hepatic disorders have been vividly discussed in this review paper.