bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety, efficacy, and operability of a newly developed absorbable adhesion barrier (GM142) in patients with primary rectal cancer scheduled for diverting ileostomy during laparoscopic surgery: Randomized controlled trial
Authors: Watanabe Jun , Yamaguchi Shigeki , Takemasa Ichiro , Yasui Masayoshi , Hirano Yasumitsu , Nakano Daisuke , Shiomi Akio , Munakata Shinya , Naito Masanori , Tsukamoto Shunsuke , Ishibe Atsushi , Kuriu Yoshiaki , Uchima Yasutake , Mori Shinichiro , Kanazawa Hideki , Wakabayashi Go , Yamada Takeshi , Ezu Muneaki , Watanabe Masahiko , Kinugasa Yusuke 
Published: January 2022

AbstractAimThe aim of this study was to compare the outcomes of GM142, a newly developed gelatin film with a concave and convex structure to a commercially available conventional film, hyaluronate‐carboxymethylcellulose.MethodsPatients with primary rectal cancer who were scheduled for diverting ileostomy during laparoscopic surgery were eligible for this study. Patients were randomized before surgery and an antiadhesion film was applied under the umbilical incision. The primary outcome was the incidence of adhesion under the midline incision confirmed by second‐look surgery for diverting ileostomy closure. The secondary outcomes were the adhesion severity score, the extent of adhesion score, the presence of intestinal obstruction, and the success of all patching.ResultsA total of 146 patients were enrolled. A total of 123 patients were included in the full analysis set. The primary outcome of “no adhesion” was observed in 66.1% in the GM142 group and 55.7% in the conventional film group. The noninferiority of GM142 to conventional film was confirmed (P = .0005). The secondary outcomes were similar between the groups. For the safety evaluation, there were no safety concerns regarding allergic reactions to gelatin or increased gelatin‐specific IgE antibody titers.ConclusionsThe noninferiority of GM142 to conventional film was shown. GM142 showed no major safety issues. The clinical safety profiles of GM142 suggested certain physiological benefits of the gelatin film as an adhesion barrier.
3D Dirac Semimetal Supported Tunable TE Modes
Authors: He Xiaoyong , Liu Feng , Lin Fangting , Shi Wangzhou 
Published: January 2022

AbstractThe tunable propagation properties of transverse electric (TE) plasmonic modes have been investigated in the mid‐IR spectral region by using air‐Dirac semimetal (DSM)‐Si asymmetric structures, including the effects of Fermi levels, temperatures, and scattering times. The results manifest that on the condition that the Fermi level of DSM layer is not very large (2|μc|<ℏω) and temperature is relatively high (about 100 K), the proposed DSM asymmetric structure supports obvious TE modes, which is quite different from the graphene symmetric structure limited to low liquid helium temperature. The transition frequency increases with Fermi level, the peak position of the real part and the saturation region of the imaginary part of effective index indicates an obvious blue shift. As temperature decreases, the contribution of interband transition becomes stronger, the 3D DSM indicates better dielectric properties and sustains stable TE mode. If scattering time is shorter than 0.1 ps, its effects on the propagation properties are very strong, resulting in a redshift of the real part of effective index. The results are very helpful to understand the tunable properties of DSM TE structures and aid the design of novel plasmonic devices, such as polarizers, modulators, and filters.
Improving Atom–Mirror Entanglement and Mechanical Squeezing in a Modulated Optomechanical System
Authors: Guo Jin‐Liang , Zhai Le‐Le 
Published: January 2022

AbstractIn this paper, the macroscopic quantum entanglement and squeezing in an unresolved‐sideband atom‐optomechanical system with a modulated optical parametric amplifier (OPA) inside the cavity are studied. Increasing the parametric gain of the OPA, the quantum‐classical correspondence between the atom‐mirror entanglement and classical nonlinear dynamics can be found. The critical point where the system experiences the transition from periodic oscillation to period‐doubling motion can be characterized by the singularity of the atom–mirror entanglement. Furthermore, the dependence of the atom–mirror entanglement and mechanical squeezing on the detuning and the parametric gain of the OPA as well as the environment temperature are investigated in detail. It is found that the atom‐mirror entanglement can be enhanced and the mechanical squeezing can be generated by modulating the OPA.
A Multiplexed Cell‐Free Assay to Screen for Antimicrobial Peptides in Double Emulsion Droplets
Authors: Nuti Nicola , Rottmann Philipp , Stucki Ariane , Koch Philipp , Panke Sven , Dittrich Petra S. 
Published: January 2022

AbstractThe global surge in bacterial resistance against traditional antibiotics triggered intensive research for novel compounds, with antimicrobial peptides (AMPs) identified as a promising candidate. Automated methods to systematically generate and screen AMPs according to their membrane preference, however, are still lacking. We introduce a novel microfluidic system for the simultaneous cell‐free production and screening of AMPs for their membrane specificity. On our device, AMPs are cell‐free produced within water‐in‐oil‐in‐water double emulsion droplets, generated at high frequency. Within each droplet, the peptides can interact with different classes of co‐encapsulated liposomes, generating a membrane‐specific fluorescent signal. The double emulsions can be incubated and observed in a hydrodynamic trapping array or analyzed via flow cytometry. Our approach provides a valuable tool for the discovery and development of membrane‐active antimicrobials.
Hydrogen‐Bonded Metal–Nucleobase Frameworks for Efficient Separation of Xenon and Krypton
Authors: Liu Ying , Wu Hui , Guo Lidong , Zhou Wei , Zhang Zhiguo , Yang Qiwei , Yang Yiwen , Ren Qilong , Bao Zongbi 
Published: January 2022

AbstractXe/Kr separation is an industrially important but challenging process owing to their inert properties and low concentrations in the air. Energy‐effective adsorption‐based separation is a promising technology. Herein, two isostructural hydrogen‐bonded metal–nucleobase frameworks (HOF‐ZJU‐201 and HOF‐ZJU‐202) are capable of separating Xe/Kr under ambient conditions and strike an excellent balance between capacity and selectivity. The Xe capacity of HOF‐ZJU‐201a reaches 3.01 mmol g−1 at 298 K and 1.0 bar, while IAST selectivity and Henry's selectivity are 21.0 and 21.6, respectively. Direct breakthrough experiments confirmed the excellent separation performance, affording a Xe capacity of 25.8 mmol kg−1 from a Xe/Kr mixed‐gas at dilute concentrations. Density functional theory calculations revealed that the selective binding arises from the enhanced polarization in the confined electric field produced by the electron‐rich anions and the electron‐deficient purine heterocyclic rings.
Sensitive Logic Nanodevices with Strong Response for Weak Inputs
Authors: Lv Wen Yi , Li Chun Hong , Yang Fei Fan , Li Yuan Fang , Zhen Shu Jun , Huang Cheng Zhi 
Published: January 2022

AbstractSensitive sensing is critical when developing new calculation systems with weak input signals (ISs). In this work, a “weak‐inputs‐strong‐outputs” strategy was proposed to guide the construction of sensitive logic nanodevices by coupling an input‐induced reversible DNA computing platform with a hybridization chain reaction‐based signal amplifier. By rational design of the sequence of computing elements (CEs) so as to avoid cross‐talking between ISs and signal amplifier, the newly formed logic nanodevices have good sensitivity to the weak ISs even at low concentrations of CEs, and are able to perform YES, OR, NAND, NOR, INHIBIT, INHIBIT‐OR and number classifier operation, showing that the DNA calculation proceeds in dilute solution medium that greatly improves the calculation proficiency of logic nanodevices without the confinement of the lithography process in nanotechnology.
Ni@C@CNT catalyst derived from CNT doped Ni‐MOF for furfural hydrogenation to tetrahydrofurfuryl alcohol
Authors: Wang Yuan , Liu Shanshan , Guo Qirui , Zhang Yidong 
Published: January 2022

AbstractConversion of biomass‐derived furfural platform compound to value‐added tetrahydrofurfuryl alcohol (THFL) molecule is a sustainable route, and an efficient nonnoble metallic catalyst is a key factor for this reaction. In this work, Ni@C@CNT composite as a highly effective catalyst for hydrogenation of furfural to tetrahydrofurfuryl alcohol was synthesized by one‐step pyrolysis of Ni‐centered metal organic framework (Ni‐MOF) doping with carbon nanotube (CNT). For comparison, Ni@C catalyst derived directly from Ni‐MOF was also synthesized. The characterization results show that the doping of CNT promotes high dispersion of active sites and formation of Ni3C phase which has Pt‐like catalytic activity. Therefore, the obtained Ni@C@CNT exhibited excellent activity in furfural hydrogenation (99.1% furfural conversion and 94.7% THFL yield at 120°C, 4 h, 4‐MPa initial hydrogen pressure). Ni@C@CNT also shows good stability in reuse test. Current work presents a facile method for preparation of nonnoble metallic catalysts with high efficiency.
Heat resistive, binder‐free 3d‐dough composite as a highly potent flame‐retardant
Authors: Dhumal Pratik S. , Lokhande Kshama D. , Bondarde Mahesh P. , Bhakare Madhuri A. , Some Surajit 
Published: January 2022

AbstractWe have synthesized sodium polyacrylate and bentonite supported phosphorous functionalized flame retardant (FR) dough material. The dough material has flame retardant and heat insulator properties. The combination of sodium polyacrylate and bentonite provided strength and flexibility, whereas the phosphorus functionalities contributed the flame retardant property to the FR‐dough. The major benefit of the FR‐dough composite is that it can be simply converted into any 3D shape without the use of any binder and can be easily connected to any surface area without the use of any adhesives. The FR‐dough was successfully applied on the wood stick and electric wire for the flame‐retardant test. These coated materials were sustained on the flame for more than 120 s without any damage, while the only sample burnt out within the 40 s. The flame retardancy and heat resistance properties of the material have been confirmed by conducting a Bunsen burner test as the burner can attain a temperature up to 1500°C. The composite also has smoke absorption and self‐healing properties along with flame retardant and heat resistive properties. This approach has a high potential in the mass production of this multifunctional FR‐dough composite.
No Added Value of Duloxetine in Patients With Chronic Pain due to Hip or Knee Osteoarthritis: A Cluster‐Randomized Trial
Authors: van den Driest Jacoline J. , Schiphof Dieuwke , Koffeman Aafke R. , Koopmanschap Marc A. , Bindels Patrick J. E. , Bierma‐Zeinstra Sita M. A. 
Published: January 2022

ObjectiveTo assess the effectiveness of duloxetine in addition to usual care in patients with chronic osteoarthritis (OA) pain. The cost‐effectiveness and whether the presence of symptoms of centralized pain alters the response to duloxetine were secondary objectives.MethodsWe conducted an open‐label, cluster‐randomized trial. Patients with chronic hip or knee OA pain who had an insufficient response to acetaminophen and nonsteroidal antiinflammatory drugs were included. Randomization took place at the general practice level, and patients received duloxetine (60 mg/day) in addition to usual care or usual care alone. The presence of centralized pain was defined as a modified PainDETECT Questionnaire score >12. The primary outcome measure was Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scores (scale 0–20) at 3 months after the initiation of treatment. Our aim was to detect a difference between the groups of a clinically relevant effect of 1.9 points (effect size 0.4). We used a linear mixed model with repeated measurements to analyze the data.ResultsIn total, 133 patients were included, and 132 patients were randomized into treatment groups. A total of 66 patients (at 31 practices) were randomized to receive duloxetine in addition to usual care, and 66 patients (at 35 practices) were randomized to receive usual care alone. We found no differences in WOMAC pain scores between the groups at 3 months (adjusted difference –0.58 [95% confidence interval (95% CI) –1.80, 0.63]) or at 12 months (adjusted difference –0.26 [95% CI –1.86, 1.34]). In the subgroup of patients with centralized pain symptoms, we also found no effect of duloxetine compared to usual care alone (adjusted difference –0.32 [95% CI –2.32, 1.67]).ConclusionWe found no effect of duloxetine added to usual care compared to usual care alone in patients with chronic knee or hip OA pain. Another trial including patients with centralized pain symptoms should be conducted to validate our results.
Recent Advances in the Domain of Cyclic (Alkyl)(Amino) Carbenes
Authors: Kumar Kushvaha Saroj , Mishra Ankush , Roesky Herbert W. , Chandra Mondal Kartik 
Published: January 2022

AbstractIsolation of cyclic (alkyl) amino carbenes (cAACs) in 2005 has been a major achievement in the field of stable carbenes due to their better electronic properties. cAACs and bicyclic(alkyl)(amino)carbene (BicAAC) in essence are the most electrophilic as well as nucleophilic carbenes are known till date. Due to their excellent electronic properties in terms of nucleophilic and electrophilic character, cAACs have been utilized in different areas of chemistry, including stabilization of low valent main group and transition metal species, activation of small molecules, and catalysis. The applications of cAACs in catalysis have opened up new avenues of research in the field of cAAC chemistry. This review summarizes the major results of cAAC chemistry published until August 2021.
Recent Advances in Constructing Higher‐Order DNA Structures
Authors: Wang Jing , Wang Dong‐Xia , Liu Bo , Jing Xiao , Chen Dan‐Ye , Tang An‐Na , Cui Yun‐Xi , Kong De‐Ming 
Published: January 2022

AbstractMolecular self‐assembly is widely used in the fields of biosensors, molecular devices, efficient catalytic materials, and medical biomaterials. As the carrier of genetic information, DNA is a kind of biomacromolecule composed of deoxyribonucleotide units. DNA nanotechnology extends DNA of its original properties as a molecule that stores and transmits genetic information from its biological environment by taking advantage of its unique base pairing and inherent biocompatibility to produce structurally‐defined supramolecular structures. With the continuously development of DNA technology, the assembly method of DNA nanostructures is not only limited on the basis of DNA hybridization but also other biochemical interactions. In this review, we summarize the latest methods used to construct higher‐order DNA structures. The problems of DNA nanostructures are discussed and the future directions in this field are provided.
Robust tool wear monitoring system development by sensors and feature fusion
Authors: Lin Yu‐Ru , Lee Ching‐Hung , Lu Ming‐Chyuan 
Published: January 2022

AbstractThis study introduces a tool wear monitoring system that uses multiple sensors and a feature fusion technique. To improve the robustness of the system, different tightening torque and spindle speed conditions were considered in the experimental design stage. Vibration signals in three coordinates and sound signals were collected and transformed by fast Fourier transform for feature extraction. Two types of features in the frequency domain were used to establish the proposed system, including the mean value features selected by the class mean scatter feature selection criterion and statistical features by Gradient Class Activation Mapping++ (Grad‐CAM++). The proposed monitoring system was established using a hierarchical neural network structure and feature fusion of the sensors. Cross‐validation was introduced to demonstrate the performance and effectiveness of our approach under various tightening torque values and spindle speeds.
Distributed appointed‐time prescribed performance attitude coordinated tracking for multiple rigid spacecraft under directed communication topology
Authors: Shi Xiao‐Ning , Zhou Zhi‐Gang , Zhou Di , Chen Xinwei 
Published: January 2022

AbstractThis paper addresses appointed‐time attitude coordinated control problem of multiple spacecraft under the directed communication topology in presence of input saturation. With only a subset of spacecrafts being able to access the information of the reference trajectory, a distributed observer is developed for each spacecraft to estimate the virtual leader's state in fixed time. Subsequently, to ensure the tracking error can achieve the preassigned transient and steady state performance, an adaptive backstepping controller is synthesized by incorporating an appointed‐time performance function with the asymmetric tan‐type barrier Lyapunov function (BLF). Furthermore, to tackle the input saturation constraint, a Nussbaum‐type function is incorporated to compensate for the time‐varying nonlinear gain arising from the derivative of the nonlinear approximation function. Different from most existing finite‐time coordination protocols, the convergence time can be appointed by the user without resorting to judicious control parameters selection. Finally, numerical simulation is conducted to assess the efficacy of the theoretical results.
ISS control for continuous‐time systems with filtered time‐varying parameter and saturating actuators
Authors: Ferreira Gabriel O. , Figueiredo Larissa S. , Lacerda Márcio J. , Leite Valter J. S. 
Published: January 2022

AbstractThis paper presents new convex conditions to design robust and linear parameter varying (LPV) gains for continuous time‐varying systems subject to saturating actuator and energy bounded disturbances. The input‐to‐state stability conditions are used to design controllers ensuring the minimization of the
‐gain between the disturbance input and the controlled output. Furthermore, optimization procedures to maximize the estimate of the region of attraction, and the bound to the control signal as well, are formulated. The efficacy of the proposed methods is illustrated with numerical examples, including a reference tracking problem, where realistic simulations are performed.
Distributed cubature Kalman filtering for nonlinear systems with stochastic communication protocol
Authors: Ju Yamei , Liu Dan , Ding Derui , Wei Guoliang 
Published: January 2022

AbstractThis paper is concerned with the distributed cubature Kalman filtering (DCKF) for a class of discrete time‐varying nonlinear systems subject to stochastic communication protocol (SCP). In order to avoid the data collisions, the SCP is introduced to randomly schedule each sensor node information from one of the neighboring nodes to the filter which is presented via not only the information of itself sensor but also the information of neighboring sensors. The considered scheduling probability of the selected node is unknown. Therefore, the exact filtering error covariance is not available. The purpose of this paper is to design a DCKF under the spherical–radial cubature rule such that an upper bound of the filtering error covariance is guaranteed by utilizing fundamental inequality. Such an upper bound is dependent on known upper and lower bounds of the scheduling probabilities. Subsequently, the desired filter matrices are given by minimizing the upper bound of the filtering error. A sufficient condition is derived by using Riccati‐like difference equations method. Besides, a recursive form of filter algorithm is designed for online computation. Finally, the usefulness of the DCKF is verified by utilizing a simulation example on the induction machines.
The Variance Gamma++ process and applications to energy markets
Authors: Gardini Matteo , Sabino Piergiacomo , Sasso Emanuela 
Published: January 2022

AbstractThe purpose of this article is to introduce a new Lévy process, termed the Variance Gamma++ process, to model the dynamics of assets in illiquid markets. Such a process has the mathematical tractability of the Variance Gamma process and is obtained by applying the self‐decomposability of the gamma law. Compared to the Variance Gamma model, it has an additional parameter representing the measure of the trading activity. We give a full characterization of the Variance Gamma++ process in terms of its characteristic triplet, characteristic function, and transition density. In addition, we provide efficient path simulation algorithms, both forward and backward in time. We also obtain an efficient “integral‐free” explicit pricing formula for European options. These results are instrumental to apply Fourier‐based option pricing and maximum likelihood techniques for the parameter estimation. Finally, we apply our model to illiquid markets, namely to the calibration of European power futures market data. We accordingly evaluate exotic derivatives using the Monte Carlo method and compare these values to those obtained using the Variance Gamma process and give an economic interpretation. Finally, we illustrate an extension to the multivariate framework.
2‐Amino‐5‐substituted‐1,3,4‐oxadiazole as chemosensor for Ni(II) ion detection: antifungal, antioxidant, DNA binding, and molecular docking studies
Authors: Sultana Razia , Arif Rizwan , Rana Manish , Ahmedi Saiema , Mehandi Rabiya , Akrema  , Manzoor Nikhat , Rahisuddin  
Published: January 2022

AbstractAn oxadiazole derivative 2 was prepared by condensation reaction through cyclization of semicarbazone in the presence of bromine; the structural confirmation was supported by1H and13C nuclear magnetic resonance (NMR) spectroscopy, Fourier transform‐infrared spectroscopy, and liquid chromatography‐mass spectrometry. Its sensing ability towards Ni2+ion was examined showing a binding constant of 1.04 × 105compared with other suitable metal cations (Ca2+, Co2+, Cr3+, Ag+, Pb2+, Fe3+, Mg2+, and K+) using ultraviolet–visible (UV–vis) and fluorescence spectroscopic studies. The minimum concentration of Ni2+ions and limit of detection was found to be 9.4 μM. A job's plot gave the binding stoichiometry ratio of oxadiazole derivative 2 vs Ni2+ions as 2:1. Furthermore, the intercalative binding mode of oxadiazole derivative 2 with calf thymus DNA was supported by ultraviolet–visible (UV–vis) and fluorescent light, viscosity, cyclic voltammetry, time‐resolved fluorescence, and circular dichroism measurements. The molecular docking result gave the binding score for oxadiazole derivative 2 as −6.5 kcal/mol, which further confirmed the intercalative interaction. In addition, the antifungal activity of oxadiazole derivative 2 was also screened against several fungal strains (C. albicans,C. glabrata, andC. tropicalis) by broth dilution and disc diffusion methods. In antioxidant studies, the oxadiazole derivative 2 showed potential scavenging activity against 2,2‐diphenyl‐1‐picrylhydrazyl and H2O2free radicals.