bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Persepsi Keamanan, Kemudahan Bertransaksi, Harga, Dan Kualitas Informasi Terhadap Minat Beli Ulang Melalui Kepuasan Pelanggan Pada Online Travel Agency (OTA) Traveloka.com
Authors: Munawaroh Munawaroh , Sulaksono Hary , Hidayah Tamriatin 
Published: February 2022

This study aims to analyze the effect of perceived security, ease of transaction, price and quality of information on buying interest through customer satisfaction at the Online Travel Agency (OTA) Traveloka.Com.
This research method uses descriptive quantitative research, data collection techniques use purposive sampling by distributing 60 questionnaires to STIE Mandala Jember students, the analytical method used is path analysis using SPSS version 20 and Sobel test calculator to test hypotheses.
The results of this study indicate that: 1) the perceived security, price and quality of information variables have a direct effect on customer satisfaction at the Online Travel Agency (OTA) Traveloka.Com, while the ease of transacting variable has no direct influence, 2) the ease of transaction and quality of information variables. Information has a direct effect on buying interest at the Online Travel Agency (OTA) Traveloka.Com, while the perceived security and price variables do not have a direct influence, 3) customer satisfaction has a direct influence on buying interest at the Online Travel Agency (OTA) Traveloka. Com, and finally 4) the customer satisfaction variable cannot mediate the relationship between the variables of perceived security, ease of transaction, price and quality of information on buying interest through customer satisfaction at the Online Travel Agency (OTA) Traveloka.Com.
PENGARUH KUALITAS PELAYANAN TERHADAP KEPUASAN KONSUMEN PADA FIFGROUP DI LUMAJANG
Authors: Kencana Dimas Julius Hari , HP Agustin , Edi Bagus Qomaruzzaman Ratu 
Published: February 2022

This study entitled The Influence Of Service Quality On Customer Satisfaction In Fifgroup In Lumajang with the aim of knowing and analyzing the effect of service quality consisting of physical evidence, reliability, responsiveness, assurance and partial empathy on consumer satisfaction at FIFGROUP Yosowilangun Branch Lumajang Regency and to find out and analyzing the effect of service quality consisting of physical evidence, reliability, responsiveness, assurance and empathy simultaneously on customer satisfaction at FIFGROUP Yosowilangun Branch Lumajang Regency. The number of samples in this study was 60 using purposive sampling technique. purposive sampling is a sampling technique using certain criteria. The testing and analysis used in this research is the data instrument test which includes the validity test and reliability test, and the classical assumption test which includes the normality test, multicollinearity test, and heteroscedasticity test, multiple linear regression analysis, the coefficient of determination and hypothesis testing which includes testing t and F test. And the results of this study: 1.) There is no effect of physical evidence on customer satisfaction at FIFGROUP Lumajang 2.) There is no effect of reliability on customer satisfaction at FIFGROUP Lumajang 3.) There is no effect of responsiveness on customer satisfaction at FIFGROUP Lumajang 4.) There is a guarantee effect on customer satisfaction at FIFGROUP Lumajang Branch 5.) There is no influence of empathy on customer satisfaction at FIFGROUP Lumajang. Suggestions from this study to further improve customer satisfaction need to increase again from employees in the company in serving consumers because these employees interact directly with consumers, especially in punctuality as well. So that it will make consumers satisfied and not hesitate to use the company's services again.
Comparison of the effect of bone induction with different exercise modes in mice
Authors: Liu Juan , He Hongyan , Tang Lu , Peng Yu , Mu Junyu , Lan Liang , Chen Cheng , Dong Zhihong , Cheng Lijia 
Published: February 2022

BACKGROUD: Calcium phosphate biomaterials have excellent bone inductivity, and exercise can promote the bone formation of biomaterials in animals, but it is not clear which exercise mode is better. OBJECTIVE: To explore the effect of different exercise modes on osteoinduction by calcium phosphate-based biomaterials which were implanted in mice. METHOD: The collagen-thermosensitive hydrogel-calcium phosphate (CTC) composite was prepared and transplanted in the thigh muscle of mice, then all mice were divided randomly into four groups (n = 10): the uphill running group, the downhill running group, the swimming group and the control group (conventional breeding). Ten weeks later, the samples were harvested, fixed, decalcified, embedded in paraffin and stained with hematoxylin and eosin (H&E), and then the osteoinduction phenomenon was observed and compared through digital slice scanning system. The area percentage of new bone-related tissues and the number of osteocytes and chondrocytes were counted and calculated. Lastly, the immunohistochemistry of type I collagen (ColI) and osteopontin (OPN) was performed to identify the new bone tissues. RESULTS: The area percentage of new bone-related tissues and the number of osteocytes and chondrocytes were positively correlated; ordering from most to least of each group were as followings: the uphill running group > the swimming group > the downhill running group > the control group. The immunostaining of ColI and OPN results showed that both of the two proteins were identified in the new bone tissues, indicating that the CTC composite could induce ectopic bone formation in mice, especially training for uphill running and swimming. CONCLUSION: Our results show that uphill running or swimming is a form of exercise that is beneficial to osteogenesis. According to this, we propose treatment with artificial bone transplantation to patients who suffer from bone defects. Patients should do moderate exercise, such as running uphill on the treadmill or swimming.
In vitro immunomodulatory effects of novel strontium and zinc-containing GPCs
Authors: Marx Daniella , Papini Marcello , Towler Mark 
Published: February 2022

BACKGROUND: Glass polyalkenoate cements (GPCs) are bio-adhesives which consist of ionomeric glass particles embedded in a poly-salt matrix. These materials have been used in dentistry and orthodontics extensively but are presently being optimized as bone putties for orthopedic applications. OBJECTIVE: This study utilized a patented ionomeric glass (mole fraction: SiO2:0.48, ZnO:0.36, CaO:0.12, SrO:0.04) to formulate two GPCs: GPC A (<45 μm particle size glass) and GPC B (45 μm–63 μm). These formulations were previously assessed for their effect on osteoblast viability and osteogenic function. However, the immunomodulatory effects of GPC A and B have not previously been investigated. METHOD: Non-toxic concentrations of (a) GPC dissolution products and (b) fragmented GPC particles were tested for their ability to affect the secretion of cytokines (TNF-α, IL-1β, IL-6 and IL-10) by rat peripheral blood mononuclear cells (PBMCs), in the presence or absence of the stimulant liposaccharide (LPS). Additionally, the ionic concentrations of Sr, Zn, Ca, and Si were measured in GPC ionic extracts, and the size, shape and concentration of fragmented GPC particles in deionized water were characterized using an optical microscope-based particle analyzer. RESULTS: The results showed that GPC A ionic products reduced the concentration of TNF-α secreted by stimulated cells compared with cells stimulated in the absence of GPC products. Interestingly, the particles released from GPC A significantly increased the secretion of both TNF-α and IL-6 from unstimulated cells, compared to control cells. CONCLUSION: Neither GPC B ionic products nor released particles were found to be biologically active with respect to PBMC cytokine secretion.
Vitamin B12 enhances the antitumor activity of 1,25-dihydroxyvitamin D3 via activation of caspases and targeting actin cytoskeleton
Authors: Atoum Manar F. , Alzoughool Foad E. , Al-Mazaydeh Zainab A. , Rammaha Majdoleen S. , Tahtamouni Lubna H. 
Published: February 2022

BACKGROUND: 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is an effective anticancer agent, and when combined with other agents it shows superior activities. Vitamin B12 has been shown to contribute to increasing the effectiveness of anticancer drugs when used in combination. Thus, the current study aimed at investigating the anticancer potential of the combination of 1,25(OH)2D3 and vitamin B12. METHODS: MTT assay was used to determine the cytotoxic activity of combining 1,25(OH)2D3 and vitamin B12 against six different cancer cell lines and one normal cell line. The surviving fraction after clonogenic assay was measured, and the effects of 1,25(OH)2D3/B12 combination on the activity of different caspases, cell adhesion, actin cytoskeleton, cell morphology, and percentage of polarized cells were evaluated. RESULTS: Vitamin B12 did not cause cytotoxicity, however, it enhanced the cytotoxicity of 1,25(OH)2D3 against cancer cells. The cytotoxic effects of 1,25(OH)2D3 and its combination with vitamin B12 was not evident in the normal mammary MCF10A cell line indicating cancer cell-specificity. The cytotoxic effects of 1,25(OH)2D3/B12 combination occurred in a dose-dependent manner and was attributed to apoptosis induction which was mediated by caspase 4 and 8. Moreover, 1,25(OH)2D3/B12-treated cells showed enhanced inhibition of clonogenic tumor growth, reduced cell adhesion, reduced cell area, reduced percentage of cell polarization, and disorganized actin cytoskeleton resulting in reduced migratory phenotype when compared to cells treated with 1,25(OH)2D3 alone. CONCLUSION: 1,25(OH)2D3 and vitamin B12 exhibited synergistic anticancer effects against different cancer cell lines. The combination therapy of 1,25(OH)2D3 and vitamin B12 may provide a potential adjunctive treatment option for some cancer types.
Estudio del territorio de la vocación turística Caso del barrio El Vado-Cuenca-Ecuador
Authors: Zambrano-Flores Pablo , Lomas-Delgado Verónica 
Published: February 2022

La investigación propone un análisis de la vocación turística, a través de las características físicas y socioculturales que tiene un territorio para la reali-zación de actividades relacionadas con el turismo, sean de ocio o recreación. El estudio se centra en el tradicional barrio El Vado de la ciudad de Cuenca, Ecuador, para diagnosticar si es apto para desarro-llar la actividad turística, tanto desde la perspectiva de la sociedad como de la capacidad instalada con que cuenta. La investigación es verificable ya que se basa en el análisis y levantamiento de información secundaria, en la cual se identificaron los principales problemas y potencialidades del sector. Por medio de entrevistas se conocieron las opiniones de los actores sociales, donde se identificaron las fortalezas que tienen el territorio y sus habitantes. Además, se aplicó la matriz metodológica para la medición y valo-ración de la vocación turística dentro de una ciudad. La mayoría de los criterios obtuvieron los resultados más altos, determinando que la zona tiene potencial para una vocación turística. Finalmente, la población se mostró abierta y apta para la implementación de esta actividad permitiendo proponer líneas estraté-gicas enfocadas al desarrollo del territorio.
Palabras clave: Vocación turística, territorio, Ecuador, El Vado, turismo.
AbstractTourist vocation is the physical and social cultural characteristics which a territory has, for the realization of activities related to tourism. In order to establish if a place like “El Vado” is adequate for tourism, research must be done on both the inhabitants of the area as well as their perspective on the matter. Three main difculties have arisen from this: the loss of identity, the reduction of traditional productive activities, and social problemsthat have led to a perception of insecurity among the residents of the surrounding neighborhoods. It is ssential to carry out an analysis of the territory to propose improvement strategies that is why this analysis has been carried out. Research is verifable because it is based on analysis and survey of secondary information, in which the main problems and potential of the sector were identifed. Furthermore, we applied the ethodological matrix for the measurement and assessment of the tourist vocation within a city. The majority of the criteria obtained the highest results, determining that the area has potential for a tourist vocation. Finally, the population proved to be open and suitable for the implementation of this activity enabled proposing strategic routes focused on the development of the area.
Keywords: Tourist vocation, Territory, Ecuador, El Vado, Tourism.
EN TORNO AL PATRIMONIO CULTURAL Y SU GESTIÓN
Authors: Diego Jaramillo-Paredes 
Published: February 2022

Durante mucho tiempo se consideró al patrimonio cultural únicamente como un campo asociado con las construcciones, y por tanto, directamente asociado con la arquitectura; sin embargo el patrimonio de los pueblos es mucho más que eso, y no solamente que se debe desarquitecturizar la noción del patrimonio, sino que también se debe incluir, necesariamente, la participación y la visión de los miembros de la comunidad, que son, realmente, los constructores y usuarios naturales de los valores patrimoniales. Este acto de desarquitecturizar el patrimonio abre nuevas y muy amplias perspectivas para tratar este tema.
Palabras clave: Patrimonio, desarquitecturizar el patrimonio, participación de los sujetos-actores en el patrimonio, gestión del patrimonio.AbstractFor a long time it was considered the cultural heritage solely as a field associated with the buildings, and therefore directly associated with architecture; but the heritage of the people is much more than that, and not only it as to change the Architectural the notion of heritage, but also we must necessarily include participation and vision of community members who really are , the builders and users of natural heritage values.This act to change the Architectural the notion of heritage, open a new and very widespread of new perspectives to address this issue.
Keywords: Heritage, change the Architectural the notion heritage, participation of subjects-actors in heritage, management of heritage.
Electrochemical Microwell Plate to Study Electroactive Microorganisms in Parallel and Real-Time
Authors: Kuchenbuch Anne , Frank Ronny , Ramos José Vazquez , Jahnke Heinz-Georg , Harnisch Falk 
Published: February 2022

Microbial resource mining of electroactive microorganism (EAM) is currently methodically hampered due to unavailable electrochemical screening tools. Here, we introduce an electrochemical microwell plate (ec-MP) composed of a 96 electrochemical deepwell plate and a recently developed 96-channel multipotentiostat. Using the ec-MP we investigated the electrochemical and metabolic properties of the EAM models Shewanella oneidensis and Geobacter sulfurreducens with acetate and lactate as electron donor combined with an individual genetic analysis of each well. Electrochemical cultivation of pure cultures achieved maximum current densities (jmax) and coulombic efficiencies (CE) that were well in line with literature data. The co-cultivation of S. oneidensis and G. sulfurreducens led to an increased current density of jmax of 88.57 ± 14.04 µA cm−2 (lactate) and jmax of 99.36 ± 19.12 µA cm−2 (lactate and acetate). Further, a decreased time period of reaching jmax and biphasic current production was revealed and the microbial electrochemical performance could be linked to the shift in the relative abundance.
Outcomes of Hospitalized Patients With COVID-19 With Acute Kidney Injury and Acute Cardiac Injury
Authors: Lu Justin Y. , Buczek Alexandra , Fleysher Roman , Hoogenboom Wouter S. , Hou Wei , Rodriguez Carlos J. , Fisher Molly C. , Duong Tim Q. 
Published: February 2022

PurposeThis study investigated the incidence, disease course, risk factors, and mortality in COVID-19 patients who developed both acute kidney injury (AKI) and acute cardiac injury (ACI), and compared to those with AKI only, ACI only, and no injury (NI).MethodsThis retrospective study consisted of hospitalized COVID-19 patients at Montefiore Health System in Bronx, New York between March 11, 2020 and January 29, 2021. Demographics, comorbidities, vitals, and laboratory tests were collected during hospitalization. Predictive models were used to predict AKI, ACI, and AKI-ACI onset. Longitudinal laboratory tests were analyzed with time-lock to discharge alive or death.ResultsOf the 5,896 hospitalized COVID-19 patients, 44, 19, 9, and 28% had NI, AKI, ACI, and AKI-ACI, respectively. Most ACI presented very early (within a day or two) during hospitalization in contrast to AKI (p &lt; 0.05). Patients with combined AKI-ACI were significantly older, more often men and had more comorbidities, and higher levels of cardiac, kidney, liver, inflammatory, and immunological markers compared to those of the AKI, ACI, and NI groups. The adjusted hospital-mortality odds ratios were 17.1 [95% CI = 13.6–21.7, p &lt; 0.001], 7.2 [95% CI = 5.4–9.6, p &lt; 0.001], and 4.7 [95% CI = 3.7–6.1, p &lt; 0.001] for AKI-ACI, ACI, and AKI, respectively, relative to NI. A predictive model of AKI-ACI onset using top predictors yielded 97% accuracy. Longitudinal laboratory data predicted mortality of AKI-ACI patients up to 5 days prior to outcome, with an area-under-the-curve, ranging from 0.68 to 0.89.ConclusionsCOVID-19 patients with AKI-ACI had markedly worse outcomes compared to those only AKI, ACI and NI. Common laboratory variables accurately predicted AKI-ACI. The ability to identify patients at risk for AKI-ACI could lead to earlier intervention and improvement in clinical outcomes.
Geomechanical Modeling and Inversion Analysis of the in-situ Stress Field in Deep Marine Shale Formations: A Case Study of the Longmaxi Formation, Dingshan Area, China
Authors: Liu Qinjie , Fu Qiang , Yang Ke , Wei Quanchao , Liu Huihu , Wu Haibo 
Published: February 2022

Based on the comprehensive analysis of wellbore characteristics in a deep shale gas field, the in-situ stress state of the shale reservoir was assessed in this study for the Longmaxi formation in the Dingshan area, Southwestern China. The data obtained from hydraulic fracturing, drilling-induced fractures, and in-situ core testing were used to determine the magnitude and direction of the maximum principal horizontal stress in five wells. Besides, hydraulic fracturing and cross-multipole array acoustic logging (XMAC) were employed to determine the vertical variation of the in-situ stress. Based on the logging interpretation and mechanical test results, the spatial distribution of rock mechanical parameters in the Dingshan area was assessed by the amplitude variation versus offset (AVO) seismic inversion. A 3D heterogeneous mechanical inversion model was realized via the ANSYS and CATIA3D finite element software packages, providing the area in-situ stress field simulation. The depth, fault strike, and position change effects on the main stress, horizontal stress difference, and horizontal stress difference coefficient were numerically simulated. The results show that the maximum principal stress azimuth was mainly concentrated in the NE20°-NE80° sector. Moreover, the development zone of natural fractures was related to the area with the highest principal stress differences. The maximum principal stress variation in the study area was mainly in the compressive range from −135 to −45 MPa, gradually increasing from east to west and south to north. The stress type mainly depended on the depth, fault strike, and rock mechanical parameters, while the stress difference and stress difference coefficient near the fault structure were relatively small. This study’s findings are considered instrumental in improving the borehole stability, determining the casing setting point, and optimizing the well location in deep shale reservoirs with similar geological conditions.
Key Processes on Triggering the Moderate 2020/21 La Niña Event as Depicted by the Clustering Approach
Authors: Cao Ting‐Wei , Zheng Fei , Fang Xiang‐Hui 
Published: February 2022

The 2020/21 La Niña was not well predicted by most climate models when it started in early-mid 2020. This paper adopted an El Niño-Southern Oscillation (ENSO) ensemble prediction system to evaluate the key physical processes in the development of this cold event by performing a clustering analysis of 100 ensemble member predictions 1 year in advance. The abilities of two clustering approaches were first examined in regard to capturing the development of the 2020/21 La Niña event. One approach was index clustering, which adopted only the 12-month Niño3.4 indices in 2020 as an indicator, and the other was pattern clustering through contrasting the evolution of sea surface temperature (SST) anomalies over the tropical Pacific in 2020 for clustering. Pattern clustering surpasses index clustering in better describing the evolution over the off-equatorial and equatorial regions during the 2020/21 La Niña. Consequently, based on the pattern clustering approach, a comparison of the selected most (five best) and least (five worst) representative ensemble members illustrated that the predominance of anomalous southeasterly winds over the central equatorial Pacific in spring 2020 played a crucial role in initiating the moderate La Niña event in 2020/21, by preventing the development of westerly winds over the warm pool. Moreover, the inherent spring predictability barrier (SPB) was still a major challenge for improving the prediction skill of the 2020/21 La Niña event when the prediction occurred across the spring season.
Association Between Weight Gain From Young to Middle Adulthood and Metabolic Syndrome Across Different BMI Categories at Young Adulthood
Authors: Wang Xiuling , Song Jiali , Gao Yan , Wu Chaoqun , Zhang Xingyi , Li Teng , Cui Jianlan , Song Lijuan , Xu Wei , Yang Yang , Zhang Haibo , Lu Jiapeng , Li Xi , Liu Jiamin , Zheng Xin 
Published: February 2022

ObjectivesWe aimed to assess the dose–response association between weight gain from young to middle adulthood and odds of metabolic syndrome, across body mass index (BMI) categories at young adulthood.MethodsBased on a national population-based screening project, middle-aged (35–64 years) participants who recalled weight at age 25 years and received standardized measurements were included. Multivariable adjusted restricted cubic splines and logistic regression models were applied.ResultsIn total, 437,849 participants were included (62.1% women, 52.0 ± 7.6 years). Larger weight gains from young to middle adulthood were associated with higher odds of metabolic syndrome at middle adulthood, with odds of 2.01 (1.98–2.05), 1.93 (1.92–1.94), and 1.67 (1.64–1.7) per 5-kg weight gain across participants who were underweight, normal-weight, and overweight/obese at young adulthood, respectively. After further adjusting for current BMI, larger weight gains still correlated with higher odds of metabolic syndrome among underweight and normal-weight participants, while an inverted U-shaped association was observed in overweight/obese participants.ConclusionsWeight maintenance from young to middle adulthood could be effective to mitigate metabolic syndrome burden, especially among underweight and normal-weight people. Historical weight gain confers varied information about metabolic syndrome risk independent of attained BMI across BMI categories at young adulthood.