bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clonal haematopoiesis of indeterminate potential: associations with heart failure incidence, clinical parameters and biomarkers
Authors: Shi Canxia , Aboumsallem Joseph Pierre , Suthahar Navin , de Graaf Aniek O. , Jansen Joop H. , van Zeventer Isabelle A. , Bracun Valentina , de Wit Sanne , Screever Elles M. , van den Berg Pieter F. , Meijers Wouter C. , Gansevoort Ron T. , Bakker Stephan J.L. , van der Harst Pim , Silljé Herman H.W. , Huls Gerwin , de Boer Rudolf A. 
Published: October 2022

AbstractAimWe aimed to analyse the association of clonal haematopoiesis of indeterminate potential (CHIP) with incident heart failure (HF) in a European population cohort.Methods and resultsFrom the prospective Prevention of Renal and Vascular End‐stage Disease (PREVEND) cohort, we included all 374 participants with incident HF and selected 1:1 age‐ and sex‐matched control subjects. Peripheral blood samples of 705 individuals were successfully analysed by error‐corrected next generation sequencing for acquired mutations at a variant allele frequency ≥2% in 27 CHIP driver genes. The median age of the study population was 65 years (interquartile range 58–70) and 35.6% were female. CHIP mutations positively correlated with age, smoking, hypertension and cardiovascular biomarkers including N‐terminal pro‐B‐type natriuretic peptide and mid‐regional pro‐A‐type natriuretic peptide, but the frequency of CHIP was comparable in individuals with incident HF and in control participants (18.4% vs. 17.3%; p = 0.69). In multivariable Cox regression models, CHIP was not significantly associated with incident HF (hazard ratio [HR] 1.24, 95% confidence interval [CI] 0.93–1.65; p = 0.144). This association, however, was modified by age (p for CHIP–age interaction = 0.002). Among people younger than 65 years, CHIP mutations were more frequently detected in the case cohort compared to the control cohort (14.2% vs. 5.8%; p = 0.009), and were significantly associated with new‐onset HF (HR 2.07, 95% CI 1.30–3.29; p = 0.002).ConclusionClonal haematopoiesis of indeterminate potential correlates with HF risk factors and biomarkers, and is associated with incident HF in subjects <65 years of age.
Ir‐Catalyzed Cascade Reaction Promotes the Formation of Geometrically Selective Enones from Bis‐allyl Alcohols
Authors: Kamishima Takaaki , Koseki Yoshitaka , Nakatsuji Hirotaka , Kumar Sanjay , Tanita Keita , Kasai Hitoshi 
Published: October 2022

AbstractEnone compounds are well‐known as useful building blocks that can be converted into a variety of valuable compounds. This study describes a synthetic method to synthesize E‐selective or multi‐substituted enones by an Ir‐catalyzed cascade reaction under reducing conditions. We found that the cascade reaction, including reduction/isomerization/dehydration, proceeds by treating bis‐allyl alcohol with Crabtree's catalyst in a hydrogen atmosphere, which forms the desired product with high diastereoselectivity. We investigated acceptable catalysts to the reaction and the synthesis of enone using di‐, tri‐ and tetrasubstituted olefin substrates. Additionally, the given results suggested a hypothesis of reaction mechanism.
Mild Photocatalytic Synthesis of Azimines
Authors: Gamby Emma , Liger François , Joucla Lionel , Lacôte Emmanuel 
Published: October 2022

AbstractWe report the photocatalytic formation of azimines upon visible light irradiation of mixtures of sulfonyl azides and electron‐rich azo reagents in the presence of IrIII complexes. The method was applied to a series of alkyl‐ and arylsulfonyl azides and azo reagents. The azimines were previously prepared using toxic reagents such as lead‐tetraacetate, or harsher UV photons. The reactions can be carried out either in batch or flow conditions. The observation that the azo reagent equilibrates under the reaction conditions and the high energy of the azide triplet state suggests that the reaction may proceed through a photocatalytic cycloaddition, rather than via a nitrene.
Emerging chemical driving force in electrocatalytic water splitting
Authors: Chen Gao , Wei Chao , Zhu Yanping , Huang Haitao 
Published: October 2022

AbstractElectrocatalytic water splitting involves the breaking/formation of chemical bonds and the concomitant dynamic reconstruction of catalyst structure, both of which, in a conventional view, are directly driven by the applied bias. However, some latest reports have demonstrated that the chemical driving force can also govern electrocatalytic water splitting. This finding provides a transformative approach to designing advanced energy materials, which calls for a thorough understanding of the underlying correlation between the chemical driving force and the corresponding water splitting performance. This review timely summarizes chemical driving force in three different scenarios. Effects of chemical driving forces on surface reconstruction, reaction rate/mechanism, and interfacial redox reactions are discussed. Finally, an outlook on the chemical driving force is provided. We aim to raise the energy community's awareness of this new vision and hope it could contribute to material design for energy storage and conversion applications.image
Holocene marine terraces as recorders of earthquake uplift: Insights from a rocky coast in southern Hawke's Bay, New Zealand
Authors: Litchfield Nicola , Morgenstern Regine , Clark Kate , Howell Andy , Grant Georgia , Turnbull Jocelyn 
Published: October 2022

AbstractOn rocky tectonic coasts, data from Holocene marine terraces may constrain the timing of coseismic uplift and help identify the causative faults. Challenges in marine terrace investigations include: (1) identifying the uplift datums; (2) obtaining ages that tightly constrain the timing of uplift; (3) distinguishing tsunami deposits from beach deposits on terraces; and (4) identifying missing terraces and hence earthquakes. We address some of these challenges through comparing modern beach sediments and radiocarbon ages with those from a trench excavated across three terraces at Aramoana, central Hikurangi Subduction Margin, New Zealand. Sedimentary analyses identified beach and dune deposits on terraces but could not differentiate specific environments within them. Modern beach shells yielded modern radiocarbon ages, regardless of position or species, showing age inheritance and habitat is likely not an issue when dating shells on these terraces. By integrating terrace mapping, stratigraphy, morphology, and radiocarbon ages we develop a conceptual model of coastal uplift and terrace formation following at least two, possibly three, earthquakes at 5490–5070, 2620–2180, and 950–650 cal. yr bp. A high step and time gap between the upper two terraces raises the possibility that at least one intervening terrace is completely eroded. The trench exposure also showed that terrace stratigraphy may differ from that inferred from surface geomorphology, with apparent beach ridges being of composite origin and draping of younger beach deposits on the outer edge of a previous terrace. Dislocation modelling and comparison of marine terrace and earthquake ages from ~4 km south and ≤ 73 km north confirms that the most likely earthquake source is the nearshore, landward‐dipping, Kairakau Fault. Alternative sources, such as multi‐fault ruptures of the Kairakau‐Waimārama faults or Hikurangi subduction earthquakes, and/or a combination of the two are also possible and should be examined in future studies.
Implementation science: A critical but undervalued part of the healthcare innovation ecosystem
Authors: Chan Sze Ling , Lum Elaine , Ong Marcus E. H. , Graves Nicholas 
Published: October 2022

AbstractHealthcare systems face many competing demands and insufficient resources. Service innovations to improve efficiency are important to address this challenge. Innovations can range from new pharmaceuticals, alternate models of care, novel devices, and the use other technologies. Suboptimal implementation can mean lost benefits. This review article aims to highlight the role of implementation science, summarize how settings have leveraged this methodology to promote translation of innovation into practice, and describe our own experience of embedding implementation science into an academic medical center in Singapore. Implementation science offers a range of methods to promote systematic uptake of research findings about innovations and is gaining recognition worldwide as an important discipline for health services researchers. Health systems around the world have tried to promote implementation research in their settings by establishing (1) dedicated centers/programs, (2) offering funding, and (3) building knowledge and capacity among staff. Implementation science is a critical piece in the translational pathway of “evidence to innovation.” The three efforts we describe should be strengthened to integrate implementation science into the innovation ecosystem around the world.
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Authors: Lam Yin Kau , Yu Jianqing , Huang Hao , Ding Xiaofan , Wong Alissa M. , Leung Howard H. , Chan Anthony W. , Ng Kelvin K. , Xu Mingjing , Wang Xin , Wong Nathalie 
Published: October 2022

Background and Aims:
Major genomic drivers of hepatocellular carcinoma (HCC) are nowadays well recognized, although models to establish their roles in human HCC initiation remain scarce. Here, we used human liver organoids in experimental systems to mimic the early stages of human liver carcinogenesis from the genetic lesions of TP53 loss and L3 loop R249S mutation. In addition, chromatin immunoprecipitation sequencing (ChIP‐seq) of HCC cell lines shed important functional insights into the initiation of HCC consequential to the loss of tumor‐suppressive function from TP53 deficiency and gain‐of‐function activities from mutant p53.

Approach and Results:
Human liver organoids were generated from surgical nontumor liver tissues. CRISPR knockout of TP53 in liver organoids consistently demonstrated tumor‐like morphological changes, increased in stemness and unrestricted in vitro propagation. To recapitulate TP53 status in human HCC, we overexpressed mutant R249S in TP53 knockout organoids. A spontaneous increase in tumorigenic potentials and bona fide HCC histology in xenotransplantations were observed. ChIP‐seq analysis of HCC cell lines underscored gain‐of‐function properties from L3 loop p53 mutants in chromatin remodeling and overcoming extrinsic stress. More importantly, direct transcriptional activation of PSMF1 by mutant R249S could increase organoid resistance to endoplasmic reticulum stress, which was readily abrogated by PSMF1 knockdown in rescue experiments. In a patient cohort of primary HCC tumors and genome‐edited liver organoids, quantitative polymerase chain reaction corroborated ChIP‐seq findings and verified preferential genes modulated by L3 mutants, especially those enriched by R249S.

Conclusions:
We showed differential tumorigenic effects from TP53 loss and L3 mutations, which together confer normal hepatocytes with early clonal advantages and prosurvival functions.
In‐phase, out‐of‐phase, bottom‐wall two‐frequency boundary temperature modulations on the onset of Rayleigh‐Bénard convection
Authors: Mathew Ansa , Pranesh S. 
Published: October 2022

AbstractThe onset of convection in a Newtonian liquid‐containing system is investigated using a two‐frequency boundary temperature. The consequences of three types of two‐frequency boundary temperature modulations have been thoroughly investigated: (i) in‐phase, (ii) out‐of‐phase, and (iii) bottom‐wall. The combined effect of two frequencies with sinusoidal and nonsinusoidal wave types is also documented under these various types of boundary temperature modulations. To facilitate the study, the Venezian method is approved and the critical Rayleigh number and its correction are calculated. The parameters resulting from the study's two frequencies of modulation are the mixing angle, , the amplitudes, , and the set of coprime integers, . The system's thermodynamics determines the range of these parameters. The research discovered that out‐of‐phase two‐frequency boundary temperature modulation is the most stable, while in‐phase is the least stable. Besides that, any combination of wave type with square wave type yields the most excellent stability. Furthermore, the two‐frequency boundary temperature modulation is more stable than the single‐frequency and no‐modulation cases.
COVID‐19 lung infection segmentation from chest CT images based on CAPA‐ResUNet
Authors: Ma Lu , Song Shuni , Guo Liting , Tan Wenjun , Xu Lisheng 
Published: October 2022

AbstractCoronavirus disease 2019 (COVID‐19) epidemic has devastating effects on personal health around the world. It is significant to achieve accurate segmentation of pulmonary infection regions, which is an early indicator of disease. To solve this problem, a deep learning model, namely, the content‐aware pre‐activated residual UNet (CAPA‐ResUNet), was proposed for segmenting COVID‐19 lesions from CT slices. In this network, the pre‐activated residual block was used for down‐sampling to solve the problems of complex foreground and large fluctuations of distribution in datasets during training and to avoid gradient disappearance. The area loss function based on the false segmentation regions was proposed to solve the problem of fuzzy boundary of the lesion area. This model was evaluated by the public dataset (COVID‐19 Lung CT Lesion Segmentation Challenge—2020) and compared its performance with those of classical models. Our method gains an advantage over other models in multiple metrics. Such as the Dice coefficient, specificity (Spe), and intersection over union (IoU), our CAPA‐ResUNet obtained 0.775 points, 0.972 points, and 0.646 points, respectively. The Dice coefficient of our model was 2.51% higher than Content‐aware residual UNet (CARes‐UNet). The code is available at https://github.com/malu108/LungInfectionSeg.
Cover Image
Authors: Chodankar Nilesh R. , Patil Swati J. , Lee Sangjin , Lee Jaeho , Hwang Seung‐Kyu , Shinde Pragati A. , Bagal Indrajit V. , Karekar Smita V. , Seeta Rama Raju Ganji , Shanmugam Ranjith Kugalur , Dubal Deepak P. , Huh Yun‐Suk , Han Young‐Kyu 
Published: October 2022

AbstractRechargeable aqueous zinc ion hybrid capacitors were developed in this work via engineering a Zn‐anode/electrolyte interface and 3D Graphene‐like Carbon Cathode. The designed hybrid device realizes the battery‐like specific energy (203 Wh kg–1) and supercapacitor‐type power capability (4.9 kW kg–1) and cycling stability (96.75% retention over 30000 cycles) at a much lower price than the commercial supercapacitors and Li‐ion batteries. This work (DOI: 10.1002/inf2.12344) provides a scalable yet cost‐effective approach for developing a next‐generation Zn‐ion‐based energy storage system.
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The SARS‐CoV‐2 specific IgG antibodies biophotonic sensor
Authors: Szczerska Małgorzata , Wityk Paweł , Listewnik Paulina 
Published: October 2022

AbstractIn this paper, we present the design and the principle of operation of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) specific immunoglobulin G (IgG) biophotonic sensor, which is based on the single‐mode telecommunication fiber. We fabricated the sensor head at the face of the single mode fiber‐28. Due to the process of bio‐functionalization, our sensor has the ability to selectively detect the SARS‐CoV‐2 specific IgG antibodies. The results of preliminary tests allowed us to correctly determine the presence of antibodies in less than 1 min in 5 μl in a volume sample of concentration of 10 μg/ml, which according to studies, corresponds to the concentration of IgG antibodies in human serum. Additionally, the tested sample can be smaller than 5 μl in volume.
Comparison of temporomandibular joint disc, meniscus, and intervertebral disc in fundamental characteristics and tissue engineering
Authors: She Yilin , Tang Shiyi , Zhu Zilin , Sun Yixin , Deng Wanyu , Wang Sicheng , Jiang Nan 
Published: October 2022

AbstractThe temporomandibular joint (TMJ) disc, meniscus and intervertebral disc (IVD) are three fibrocartilage discs, which play critical roles in our daily life. Their degeneration contributes to diseases such as TMJ disorders, osteoarthritis and degenerative disc disease, affecting patients' quality of life and causing substantial morbidity and mortality. Interestingly, similar in some aspects of fundamental characteristics, they exhibit differences in other aspects such as biomechanical properties. Highlighting these similarities and differences can not only benefit a comprehensive understanding of them and their pathology but also assist in future research of tissue engineering. Likewise, comparing their tissue engineering in cell sources, scaffold and stimuli can guide imitation and improvement of their engineered discs. However, the anatomical structure, function, and biomechanical characteristics of the IVD, TMJ, and Meniscus have not been compared in any meaningful depth needed to advance current tissue engineering research on these joints, resulting in incomplete understanding of them and their pathology and ultimately limiting future research of tissue engineering. This review, for the first time, comprehensively compares three fibrocartilage discs in those aspects to cast light on their similarities and differences.
Bifunctional manganese ferrite nanoparticles: Tuning their efficiency for aniline polymerization and polyaniline nanocomposites for boosting adsorption of organic dyes
Authors: Gemeay Ali H. , El‐Helaly Abeer A. , El‐Sheikh Mohamed Y. , El‐Daly Hosny A. 
Published: October 2022

AbstractThe uniqueness of this work is the comparison of manganese ferrites/polyaniline (MnxFe3 − xO4/PANI) produced using K2S2O8 as an oxidant for aniline with the efficacy of spinel manganese ferrite with various Mn2+ ratios for the polymerization of aniline. The structural and morphological properties of the nanocomposites were characterized by thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT‐IR), X‐ray powder diffraction (XRD), vibrating sample magnetometer (VSM), scanning electron microscopy (SEM), energy‐dispersive X‐ray spectroscopy (EDX), transmission electron microscopy (TEM), and Brunauer‐Emmett‐Teller (BET) techniques. XRD results confirmed the formation of a single‐phase cubic spinel structure with a lattice constant of approximately 8.3 Å. The surface enriched by Mn2+ exhibited an enhanced valence of +3 and +4, increased lattice oxygen content, facilitated ferrite reduction, and improved the oxidative performance of Fe3+. The saturation magnetization decreased with an increase in Mn+2 ratios and PANI contents. The nanocomposites exhibited excellent adsorption of Lanaset Brown B dye, which was investigated as a model textile dye. Various adsorption capacities (qmax) for the nanocomposites were calculated in a range of 122.39–215 mg/g, depending on the synthesis conditions. Optimization parameters, such as pH, adsorbent dose, and initial concentration, as well as reusability, were described. The Langmuir isotherm is a better model for describing the adsorption process of the nanocomposites. An evaluation of thermodynamic parameters suggests the sorption process is feasible, spontaneous, and endothermic.
The relationship between metabolic dysfunction‐associated fatty liver disease and low muscle mass in an asymptomatic Korean population
Authors: Seo Ji Yeon , Cho Eun Ju , Kim Min Joo , Kwak Min‐Sun , Yang Jong In , Chung Su Jin , Yim Jeong Yoon , Yoon Ji Won , Chung Goh Eun 
Published: October 2022

AbstractBackgroundMetabolic (dysfunction)‐associated fatty liver disease (MAFLD) emphasizes the metabolic dysfunction in nonalcoholic fatty liver disease (NAFLD). Although the relationship between low muscle mass and NAFLD has been suggested, the effect of MAFLD on low muscle mass is yet to be investigated. In this study, we examined the relationship between MAFLD and low muscle mass in an asymptomatic Korean population.MethodsExaminees who underwent FibroScan® and bioelectrical impedance analyses on the same day during the period of June 2017 to December 2019 were included. Hepatic steatosis was diagnosed using controlled attenuation parameter (CAP) with two cut‐off values of 248 and 294 dB/m. Low muscle mass was defined based on appendicular skeletal muscle mass/body weight (wt) or body mass index (BMI) ratios of two standard deviations below the sex‐specific mean for healthy young adults. Subjects were divided into four subgroups: diabetic MAFLD (presence of diabetes mellitus [DM]), metabolic dysfunction (MD) MAFLD (≥2 metabolic abnormalities without DM), overweight MAFLD (overweight/obese without DM and <2 metabolic abnormalities) and no MAFLD.ResultsAmong all of the 6414 subjects (mean 53.9 years of age; 85.4% male), the prevalence of MAFLD was 49.9% and 22.7% for CAP cut‐off values of 248 and 294 dB/m, respectively. In the multivariate analysis, MAFLD was associated with an increased risk of both low muscle mass_wt (odds ratio [OR] 1.80, 95% confidence interval [CI] 1.38–2.35, P < 0.001) and low muscle mass_BMI (OR 1.31, 95% CI 1.01–1.70, P = 0.042). The risk of low muscle mass_wt and low muscle mass_BMI increased the most in the diabetic MAFLD subgroup compared with the no‐MAFLD group (OR 2.11, 95% CI 1.51–2.96, P < 0.001 and OR 1.51, 95% CI 1.08–2.13, P = 0.017). There was an increased risk of low muscle mass_wt in the MD MAFLD subgroup (OR 1.73, 95% CI 1.31–2.28, P < 0.001). Comparable results were observed when the CAP cut‐off value of 294 dB/m was applied.ConclusionsThe presence of MAFLD is significantly associated with increased risk of low muscle mass with varying risks according to the MAFLD subgroups. Clinicians should be aware of the differentiated risk of low muscle mass across the subgroups of MAFLD.