bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a Theoretical Framework for Logistics Outsourcing
Authors: BOLUMOLE YEMISI A. , FRANKEL ROBERT , NASLUND DAG 
Published: June 2022

Abstract
Outsourcing has become popular in management literature and practice. The way in which it is implemented, however, differs from one organization to another. This makes our understanding of the concept very difficult because outsourcing means different things to different organizations in different situations. One reason for this confusion may be the lack of established theoretical frameworks for evaluating organizations' decisions and their application and impact on logistics. This article applies multiple social science theoretical perspectives to develop a framework within which logistics outsourcing decisions can be examined and evaluated.
The Role of Information Integration in Facilitating 21 st Century Supply Chains: A Theory-Based Perspective
Authors: SPEIER CHERI , MOLLENKOPF DIANE , STANK THEODORE P. 
Published: June 2022

Abstract
Existing literature provides a number of examples that illustrate how systems that integrate information from multiple organizations can support chain capabilities. The literature, however, lacks theoretical support to facilitate an understanding of the magnitude of information system integration required to support the scope of relational and supply chain strategies an organization may have in place. This article uses the strategy-structure-performance paradigm to position information integration relative to the nature of relationships within the broader supply chain strategies a firm employs. The framework presented is a first step towards a more holistic and theory-based approach to understanding the link between information integration and supply chain performance, and is designed to serve as a basis for future research in this area.
1483-PUB: SD and CV but Not TIR Are Risk Factors of Sudomotor Dysfunction in Patients with Type 2 Diabetes
Authors: CHEN XUEYAN , XU HUAN , YANG XUBIN , XU WEN 
Published: June 2022

Object: This study aimed to explore the relationship between Glycemic variability parameters (GV) and sudomotor function in patients with type 2 diabetes.
Methods: All subjects underwent 3d-CGM in parallel with Sudoscan to assess GV and sudomotor function respectively. Sudomotor dysfunction was defined as hands mean electrochemical skin conductance (HESC) &lt; 60 µS.
Results: Among the enrolled 60 patients (53% male, 53±14 years old) , 50% patients were presented with sudomotor dysfunction (SDY group) while the other 50% patients were normal (normal group) . Compared with normal group, patients in SDY group showed an increased level of Standard deviation (SD) and coefficient of variation (CV) (P = 0.001) while time in range (TIR) level was decreased (P = 0.034) . In Spearman correlation analysis, HESC was negatively related with SD (r=-0.29, P= 0.03) and CV (r=-0.27, P= 0.04) , respectively. Logistic regression analysis demonstrated that SD (OR = 0.18, P = 0.018) and CV (OR = 0.82, P = 0.015) but not TIR (OR =2.41, P =0.11) were independent risk factors for the presence of sudomotor dysfunction after adjusting for confounding values.
Conclusions: SD and CV, but not other glycemic variability parameters including TIR, are risk factors of sudomotor dysfunction in Patients with type 2 diabetes.
Key words: Sudomotor Dysfunction; Glycemic Variability; Type 2 Diabetes

Disclosure
X.Chen: None. H.Xu: None. X.Yang: None. W.Xu: None.

Funding
Natural Science Foundation of Guangdong Province [2018A030313915]; Medical Scientific Research Foundation of Guangdong Province of China [A2018286].
1485-PUB: Assessing Correlates of Microvascular Complications among Patients with Diabetes Mellitus
Authors: IZUORA KENNETH , ALVER AMALIE , BASU ARPITA , BATRA KAVITA , WILLIAMS SHELLEY J. , EBERSOLE JEFFREY L. 
Published: June 2022

Background: Microvascular complications associated with diabetes (DM) are important predictors of morbidity and mortality. Understanding the factors associated with these complications is important in reducing their burden.
Method: Using a cross-sectional study design, seventy-one ambulatory patients with Type 2 DM (female 60.6%, white 36.6%, mean age 64.1± 10.3 years, and mean duration of DM 15.8±9.1 years) were recruited using an investigator-administered questionnaire and chart review. Variables of demographics, smoking, HbA1c, DM duration, and complications were collected. CRP was measured and oral health status was assessed by a clinical exam. Data were analyzed using Chi-square/Fisher exact tests and binomial logistic regression (SPSS version 27) .
Results: A larger proportion of patients with neuropathy, retinopathy or nephropathy were completely edentulous compared to those without these complications (45.3% vs. 10.3%; p=0.002) . The likelihood of having microvascular complications based on selected independent variables is shown in the table.
Conclusions: In this DM patient sample, advancing age and being completely edentulous were significantly associated with an increased likelihood of having microvascular complications. Our findings may reflect some similarities between underlying risk factors that contribute to microvascular complications of DM and tooth loss.

Disclosure
K.Izuora: Research Support; Novo Nordisk. A.Alver: None. A.Basu: None. K.Batra: n/a. S.J.Williams: None. J.L.Ebersole: None.
1490-PUB: Nutritional Deficiencies in Persons with Diabetes in Southwest Virginia
Authors: BEHNKE ANDREW , UHRIG JARROD , MUSTAFA KATHERINE , JONES KATHRYN 
Published: June 2022

Introduction: Nutritional factors are associated with diabetes development and control. In addition to carbohydrate excess, other dietary contributions are decreased magnesium and fiber intake. Magnesium deficiency is related to beta cell dysfunction. Decreased dietary fiber intake is implicated in poor glycemic control. The intake of both fiber and magnesium among those with diabetes is not well known. This study provides objective data on the diet content of adults with diabetes in our area of Roanoke, VA where an estimated 11.6 % of the population has diabetes.
Methods: 33 adult volunteers with diabetes recorded their food intake over 24 hours via access to the Automated Self-Administered 24-hour (ASA24®) dietary assessment tool. Macro and micronutrient intakes were calculated with reference intakes provided by RDA guidelines. The lowest reference intake was used to calculate pooled comparison for all ages by gender. P-values were calculated using one-sample t tests comparing sample averages with reference values. Logistic Regressions were used to evaluate the effect of age and sex on outcome.
Results: The nutritional content of our participants with diabetes did not meet RDA guidelines with no significant age or sex differences between groups. Total calories were 2314 for men and 1862 for women. Carbohydrate intake exceeded the ADA recommended amount in 83 % of men (218g/d) and 67 % of women (196g/d) (p&lt;0.01) . In addition, 83% of men and 76% of women did not meet recommended magnesium intake, averaging 314 ± 166 mg/d for men (p&lt;0.05) and 264 ± 83 mg/d for women (p&lt;0.01) . Finally, 100% of men and 90% of women did not meet reference fiber intake, averaging ± 9 g/d for men (p&lt;0.01) and 14 ± 7 g/d for women. (p&lt;0.01) .
Conclusion: In addition to excessive carbohydrates, magnesium and fiber intake were significantly deficient among our population of patients with diabetes. These results may help to tailor diet interventions in future investigations for more directed nutrition approaches to improve glycemic control.

Disclosure
K. Mustafa: None. K. Jones: None.

Funding
Carilion Clinic RAPDiabetes Nutrition Study IRB 21-1307
1491-PUB: Demographic and Psychosocial Predictors of Diabetes Risk and Glycemic Control in Hispanic/Latino Adults
Authors: VITUS DARYA , REGAN TIMOTHY , FIELDS SHERECCE A. , GLANTZ NAMINO M. , KERR DAVID 
Published: June 2022

In the U.S., Hispanic/Latino adults face a disproportionate burden of type 2 diabetes (T2D) , in part due to biological factors, including poor glucose control, and diagnosis delays. Beyond biology, social and environmental factors account for majority of risk for T2D progression. In this study, demographic and psychosocial predictors of T2D diagnosis and glycemic control were evaluated among Hispanic/Latino adults with T2D (Morales et al., in BMC Endocrine Disorders, 2020) . T2D was reported by 83% of participants (N=187; 90% Mexican-origin) . Of those with T2D, 69% were female (vs. 47% without T2D) , average age was 58.8±10.2 years (vs. 52.7±12.1 years without T2D) , and 60% had HbA1c &gt; 7%. Females with T2D had a weight of 165.4±31.9; males 172.3±26.3 lbs. (vs. 164.3±36.4 for females and 180.5±30.5 lbs. for males without T2D) . A categorical classification algorithm (Rokach & Maimon, Data Mining and Knowledge Discovery Handbook, 2010) identified T2D diagnosis as most strongly predicted by older age, lower weight, and greater perceived stress (Figure 1A) . Poor glycemic control was most strongly predicted by faith/spirituality, trust in physician, and depression symptomatology (Figure 1B) . T2D interventions for Hispanic/Latino adults should consider how demographic and psychosocial determinants differentially impact and perhaps even predict T2D risk, diagnosis, and glycemic control outcomes.

Disclosure
S.A. Fields: None. N.M. Glantz: Research Support; Abbott. D. Kerr: Advisory Panel; Abbott Diabetes, Novo Nordisk A/S, Sanofi. Consultant; Evidation Health. Research Support; Novo Nordisk A/S. Stock/Shareholder; Glooko, Inc., Hi.Health.
1498-PUB: Metformin Use in Overweight Patients with Type 1 Diabetes from Brazilian Type 1 Diabetes Study Group (BRAZDIAB)
Authors: RODACKI MELANIE , ZAJDENVERG LENITA , DANTAS JOANA R. , RAMOS MARIA E.N. , NEGRATO CARLOS , GOMES MARILIA B. 
Published: June 2022

Metformin is an unexpensive and safe drug for treating type 2 diabetes (T2D) that may also have benefits for overweight (OW) patients with type 1 diabetes (T1D) .
Objective: To investigate differences between OW adults with T1D that used metformin + insulin vs. those that used only insulin.
Methods: This was an observational study evaluating adults (≥18 years old) with body mass index (BMI) ≥ 25kg/m2. BRAZDIAB was a retrospective, observational study with T1D patients conducted in Brazilian cities. Clinical data were compared between patients who used metformin as adjuvant therapy (group 1 - G1) vs. those who did not use it (group 2- G2) . Mann-Whitney, Chi Square and linear regression tests were used for statistical analysis.
Results: 6patients were included and 130 (21.5%) used metformin (mean dose: 1258 mg/day) for a mean period of 39.68 ± 38.78 months. Both groups had similar age, T1D duration and insulin U/kg/day (p=0.73; 0.649 and 0.5, respectively) . G1 exhibited higher HbA1c, total cholesterol, triglycerides, BMI and diastolic blood pressure (p=0.03, 0.08, &lt;0.01, &lt;0.and 0,018, respectively) than G2. Metformin use predominated in females (p=0.03) , those with relatives with T2D (p=0.019) , hypertension (p=0.06) and acanthosis nigricans (p=0.047) . G1 had higher frequency of previous infarction (3.17% vs. 0.47%;p=0.03) than G2. A multivariate analysis confirmed an independent association between metformin use and HbA1c (9.17±1.9 vs. 8.64±1.72%; p=0.001) as well as BMI (29.8±3.8 vs. 28,1±3.0kg/m2; p=0.001) .
Conclusions: Metformin use was associated to higher BMI, clinical characteristics of T2D and worse glycemic control, but the differences could reflect the cause of prescription rather than the consequences.

Disclosure
M.Rodacki: None. L.Zajdenverg: None. J.R.Dantas: None. M.E.N.Ramos: None. C.Negrato: None. M.B.Gomes: n/a.

Funding
CNPQ
1510-PUB: Genetic Variants in PIKFYVE, SAC3/FIG4, and ARPIKFYVE/VAC14 as Risk Factors for Development of Type 2 Diabetes in Obesity
Authors: SHISHEVA ASSIA , SBRISSA DIEGO , SEYOUM BERHANE , LIU WANQING , IKONOMOV OGNIAN 
Published: June 2022

Obesity is a major risk factor for Type 2 Diabetes (T2D) yet the majority of obese subjects never develop T2D and their metabolic tissues never lose insulin sensitivity. This suggests a key role of genetic predisposition to T2D development in obesity. We have assessed for the first time if single nucleotide variants (SNVs) within three genes, i.e., PIKFYVE, SAC3/FIG4 and ARPIKFYVE/VAC14, proposed to control glucose homeostasis, are associated with development of T2D in obesity. Assembled in a complex, the protein products of the 3 genes regulate synthesis and turnover of 2 signaling lipids, i.e., PtdIns (3,5) P2 and PtdIns5P. We performed exome sequencing using abdominal fat derived from bariatric surgeries of morbidly obese men (n=32) and morbidly obese women (n=64) with or without T2D (48 subjects/group) . The two groups were with similar mean BMI and age. Out of a total of 942 SNVs identified in the three genes, 7 were associated with T2D in obesity via logistic regression analysis: 2 in PIKFYVE (rs6755550, rs12624141) , 2 in SAC3/FIG4 (rs17612996, rs9386844) and 3 in ARPIKFYVE/VAC14 (rs1875941, rs2242126, rs7201952) (p&lt;0.05; n=48) , all located in noncoding regions of the three genes and yet unlinked to a disease. Notably, the PIKFYVE SNVs were more frequently associated with T2D in the group of women (n=32) than that of men (n=16) . Further analysis of women’s group uncovered two additional T2D-associated SNVs located in the adipose super-enhancer of the PIKFYVE gene (rs2118296, rs10208655) . A constellation of the latter two and the PIKFYVE SNV rs6755550 was seen in 25% of the morbidly obese women with T2D but not in those without T2D (n=32) . Together, our data indicate for the first time that SNVs in the three genes may be associated with development of T2D in morbidly obese patients. Our finding for certain T2D-associated SNVs located in the PIKFYVE adipose super-enhancer suggests a mechanism whereby faulty PIKfyve expression in fat tissue could lead to T2D in morbid obesity.

Disclosure
D. Sbrissa: None. B. Seyoum: None. W. Liu: None.

Funding
Department of Defense, Peer Reviewed Medical Research Program (W81XWH-17-1-0060)
1515-PUB: Opposite Effects of Low-Carbohydrate High-Fat Diet on Metabolism in Humans and Mice
Authors: XIA XINYI , CAI LINGLI , GU YUNJIE , YIN JUN 
Published: June 2022

Aims: Low-carbohydrate diet (LCD) , characterized by low consumption of carbohydrate and high intake of fat, is well known to decrease body weight and blood glucose in humans. However, in animal experiments, high-fat diet (HFD) is widely used to induce dietary obese model with metabolic disorders. The study aims to explore why LCD/HFD has the opposite effects on humans and animals.
Methods: Twenty-two adults with overweight or obesity were enrolled to receive LCD for three weeks. The subjects were divided into two groups according to whether carbohydrate intake is below 10% by calories, and their weight loss and glucose homeostasis were compared. C57 mice were randomly assigned to five groups: chow diet (CD) , HFD with respectively 60%, 70% and 75% fat (cocoa butter) by calories and 60% fat (lard) by calories (60%HFD-L) , and metabolism of mice was evaluated.
Results: In this trial, subjects who consumed less carbohydrate had greater weight loss and better glycemic control compared with the others. The questionnaires revealed that most of the subjects favored high-carbohydrate (HC) food rather than low-carbohydrate food. However, in mice, HFD groups showed more weight gain and higher blood glucose compared with CD group. When provided with CD and HFD at the same time, mice ate little CD. Besides, we found HFD group had lower mRNA level of Npy and Agrp and higher mRNA level of Pomc and Cartpt in hypothalamus in comparison with CD group. Among HFD with coco butter groups, mice took in more calories and gained more weight as the fat content in diet increases. Compared with HFD with coco butter groups, mice in 60%HFD-L group consumed even more calories, and had heavier body weight and poorer glucose metabolism.
Conclusion: LCD has opposite effects on metabolism in humans and mice because of different food preferences. People prefer HC food while mice favor HFD. Mice consume more and feel less hungry when the diet contains higher proportion of fat, which leads to poorer metabolic status. Besides, mice prefer lard to coco butter.

Disclosure
X.Xia: None. L.Cai: None. Y.Gu: None. J.Yin: None.

Funding
National Natural Science Foundation of China (No. 82070885) ,Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support (No. 20172025)
PENGEMBANGAN BAHAN AJAR E-BOOK BERBASIS KOOPERATIF-STAD PADA MATA KULIAH PENJAS SD UNTUK MAHASISWA PGSD FIP UNIMED
Authors: Siregar Fajar Sidik , Siregar Arifin , Tarigan Daitin 
Published: June 2022

Penelitian ini bertujuan untuk: (1) untuk mengetahui kelayakan Bahan Ajar E-Book Berbasis Kooperatif-STAD pada Mata Kuliah Penjas SD untuk Mahasiswa PGSD FIP UNIMED, dan (2) untuk mengetahui respon mahasiswa terhadap Bahan Ajar E-Book Berbasis Kooperatif-STAD pada Mata Kuliah Penjas SD untuk Mahasiswa PGSD FIP UNIMED. Metode penelitian yang digunakan adalah penelitian dan pengembangan (R&D) dengan mengadaptasi model dengan menggunakan model 4-D (Define, Design, Development and Dissemination). Lokasi pelaksanaan penelitian dilakukan di prodi PGSD FIP Unimed yang terletak di Jl. Willem Iskandar / Pasar V, Medan. Populasi penelitian ini adalah seluruh mahasiswa PGSD Unimed stambuk 2020 berjumlah 225 mahasiswa yang terdiri dari 11 (A-K) kelas reguler dan ekstensi. Sampel penelitian ini dilakukan secara acara kelas dan terpilihlah satu kelas yakni kelas F Reguler 2020 yang berjumlah 40 mahasiswa. Hasil penelitian menunjukkan bahwa bahan ajar e-book berbasis Kooperatif-STAD pada mata kuliah Penjas SD yang dikembangkan telah divalidasi oleh validator ahli media pada tahap I memperoleh hasil persentase kelayakan sebesar 73,80% termasuk dalam kriteria “layak” dan pada tahap II memperoleh hasil persentase kelayakan sebesar 95,20% termasuk dalam kriteria “sangat layak”. Serta menurut validator ahli materi pada tahap I hasil persentase kelayakan sebesar 75,55% termasuk dalam kriteria “layak” dan pada tahap II memperoleh hasil persentase kelayakan sebesar 92,22%. termasuk dalam kriteria “sangat layak”. Pada tahap uji coba lapangan kriteria keefektifan tercapai dengan jumlah mahasiswa yang mencapai 40 orang pada post-test atau sekitar 89,47%. Maka dari itu dapat disimpulkan bahwa bahan ajar e-book berbasis Kooperatif-STAD pada mata kuliah Penjas SD untuk mahasiswa PGSD FIP UNIMED layak digunakan oleh siswa saat proses pembelajaran.
Studi Efektivitas Model Manajemen Pendidikan Seni Rupa
Authors: Sinaga Osberth 
Published: June 2022

Studi tentang manajemen pendidikan Rupa dilakukan untuk memperoleh model manajemen pendidikan seni yang efektif. Sejak lama telah terjadi fenomena kegelisahan di dunia pendidikan tentang efektifitas proses pendidikan seni yang terkesan masih belum produktif dan efisien . Hal ini dapat dilihat pada proses-proses pendidikan di banyak sekolah, misalnya tentang penataan kurikulum, penyusunan perangkat pembelajaran, kesediaan tenaga guru yang masih banyak bukan dari lulusan yang sesui bidang setudi, materi dan peralatan yang belum memadai, serta sistem menejemen yang masih kurang efektif. Pendidikan seni yang efektif dibutuhkan inovasi manajemen yang baik pula. Untuk menciptakan sebuah manajemen pendidikan seni yang efektif dan baik sangat penting dalam melibatkan pakar atau ahli dibidangnya. Hal tersebut tentu niscaya akan mampu membawa hasil produk manajemen seni yang memiliki karakteristik dan berdampak pada implementasi yang sesuai dengan kebutuhan proses pembelajaran yang efektif. Manajemen dalam sebuah pendidikan seni merupakan kebutuhan untuk memudahkan pencapaian tujuan pendidikannya, serta dibutuhkan dalam mengelola segela sumber daya yang ada, misalnya seperti sarana prasarana, waktu, SDM, dan metode yang inovatif, efektif dan efisien. Berdasarkan hal-hal tersebut sangat penting melibatkan banyak pihak kususnya para ahli dibidang manajemen pendidikan seni yang akan dapat menghasilkan formulasi manajemen yang efektif dalam menjalankan kurikulum, sarana prasarana, dan tenaga pengajar yang sesuai dengan ciri khas pendidikan seni yang terprogram dalam fungsi manajemen pendidikan seperti : 1) perencanaan, 2) pengorganisasian, 3) pelaksanaan dan 4) evaluasi.
PERLAKUAN AKUNTANSI TERHADAP MAIN PRODUCT DAN BY PRODUCT SERTA PENGARUHNYA TERHADAP LABA PERUSAHAAN (STUDI KASUS PADA PABRIK TAHU DAN TEMPE MUN KOTA MUARADUA SUMATERA SELATAN)
Authors: Sari Yesi Permata , Suyanto Suyanto , Zanaria Yulita 
Published: June 2022

The study aims to determine the accounting treatment of company profit at the tofu and tempe factories muaradua city, south sumatra. This data pf obtained from interviews and documentation, rrsearch data was carried using qualitative describtif data analysis,namely ricogenition, easurementh and presentation. The result of this data indicate that the tofu and tempe factoties muaradua city south sumatra calculate in main product and by product using market values of reversals. In the metode calculation of market value it can be seen that the production cosh by product sales increase the company profit by Rp.24.273/kg. Therefore,by product sales increase the comlany profit By Rp. 238,551,310.
MAIN PRINCIPLES OF THE EDUCATIONAL WORK WITH CHILDREN-MIGRANTS IN THE USA
Authors: Kozubovska Iryna , Myhalyna Zoriana 
Published: June 2022

This article deals with the problem of migration and educational work with children-migrants in the USA. It is underlined that migration is widely spread today and many countries are involved in this process, including Ukraine. America is known as a country of migrants. This country differs from average multicultural countries in a range of peculiarities, one of which is the fact that cultural interaction was not within an individual ethnos, but within immigrants – descendants of different countries, representatives of various cultures. On the territory of the country there live national minorities and as a result of constant mass immigration new ethno-cultural groups are formed. It is recognized that problem of immigrants is really urgent in USA. Cultural diversity demands special approaches to the problem. One of them is the policy of multiculturalism and multicultural education. The aim of the study is to reveal the most important peculiarities of educational work with children-migrants in USA. Mainly theoretical research methods have been used in this study: analysis of American scientific sources for the: systematisation and generalisation of available data; defining of the essence of basic concepts; identification of the current state of the problem under consideration and possibilities for its solution. It is noted that educational work with children-migrants in USA is based on some particular principles (complex research of each pupil-migrant, individual approach, humanism, preservation of mental health and others). All of them are analyzed in the article. Special attention is paid to the problem of teachersʼ training in the context of multicultural education. It is emphasized that only competent multicultural teacher is able to work successfully with children-migrants and solve the problem of their adaptation and integration into the culture of other people. The possibilities of using positive American experience of the main principles of educational work with children-migrants in the context of multicultural education have been outlined.