bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship of maternal and child methylation of the glucocorticoid receptor NR3C1 during early childhood and subsequent child psychopathology at school-age in the context of maternal interpersonal violence-related post-traumatic stress disorder
Authors: Cordero María I. , Stenz Ludwig , Moser Dominik A. , Rusconi Serpa Sandra , Paoloni-Giacobino Ariane , Schechter Daniel Scott 
Published: August 2022

IntroductionInterpersonal violent (IPV) experiences when they begin in childhood and continue in various forms during adulthood often lead to chronic post-traumatic stress disorder (PTSD) that is associated in multiple studies with hypocortisolism and lower percentage of methylation of the promoter region of the gene coding for the glucocorticoid receptor (NR3C1). This prospective, longitudinal study examined the relationship of NR3C1 methylation among mothers with IPV-related PTSD and their toddlers and then looked at the relationship of maternal NR3C1 methylation and child psychopathology at school age.MethodsForty-eight mothers were evaluated for life-events history and post-traumatic stress disorder via structured clinical interview when their children were ages 12–42 months (mean age 26.7 months, SD 8.8). Their children's psychopathology in terms of internalizing symptoms and externalizing behaviors was evaluated using the Child Behavior Checklist at ages 5–9 years (mean age 7 years, SD 1.1). Percentage of methylation for the NR3C1 gene promoter region was assessed from DNA extracted from maternal and child saliva using bisulfite pyrosequencing. Data analysis involved parametric and non-parametric correlations and multiple linear and logistic regression modeling.ResultsLogistic regression models using child NR3C1 methylation as the dependent variable and maternal NR3C1 methylation and PTSD group status as predictors, as well as the interaction indicated that all three of these significantly predicted child NR3C1 methylation. These findings remained significant when controlling for child age, sex and maternal child abuse history. Overall, maternal NR3C1 methylation when children were toddlers was negatively and significantly associated with child externalizing behavior severity at school age.DiscussionWe found that correlations between mothers and their children of NR3C1 methylation levels overall and at all individual CpG sites of interest were significant only in the IPV-PTSD group. The latter findings support that NR3C1 methylation in mothers positively and statistically significantly correlates with NR3C1 methylation in their children only in presence of IPV-PTSD in the mothers. This maternal epigenetic signature with respect to this glucocorticoid receptor is significantly associated with child behavior that may well pose a risk for intergenerational transmission of violence and related psychopathology.
COVID-19 infection prevention and control procedures and institutional trust: Perceptions of Palestinian healthcare workers
Authors: El Sharif Nuha , Ahmead Muna , Imam Asma 
Published: August 2022

BackgroundLack of trust in institutional control measures during Coronavirus disease 2019 (COVID-19) outbreaks may affect healthcare workers' (HCWs) levels of stress and wellbeing, and as a consequence, may influence their trust and confidence in their organization. This study aims to understand factors associated with healthcare workers perceptions of trust in organizational preparedness, communication, and infection risk during the COVID-19 pandemic.MethodsA cross-sectional study was conducted among HCWs (n = 876) in 16 COVID 19 healthcare facilities between October and December 2020 in Palestine (Gaza Strip, West Bank and East Jerusalem). A stratified purposive sample using an online self-administered Arabic version of a questionnaire was used for data collection. The questionnaire used for this study was adapted from the World Health Organization Blueprint Novel Coronavirus Perceptions of healthcare workers regarding local infection prevention and control procedures for a COVID-19 research protocol.Data were analyzed using Statistical Package for Social Sciences software version 23. In the bivariate analysis, T-test, one-way ANOVA and χ2 test were used at a significant p-value &lt; 0.05. In the multivariable logistic regression analyses, the adjusted odds ratios and its 95% confidence intervals are presented.ResultsFindings showed that confidence in the systems' ability to manage COVID-19 cases, encouragement and support from senior medical/nursing staff to apply recommended IPC measures, and good levels of mental health increased trust in the organization. Additionally, receiving proper training on IPC procedures for other communicable diseases, having access to clear policies and procedures related to IPC procedures for COVID-19, and providing PPE during the previous clinical shift also increased trust. However, the intention to use recommended PPE when treating patients with suspected or confirmed COVID-19 when having access to it and feeling emotional was negatively correlated with this trust.ConclusionsHCWs should be provided with clear, accessible communications about policies and protocols, as well as training about infection prevention and control, personal protective equipment, and support during pandemics to increase their trust in the healthcare system. Additionally, the improvement in HCWs' wellbeing can be attributed to a greater sense of trust in institutions.
Association between sleep duration and chest pain in US adults: A cross-sectional study
Authors: Chen Wei , Wang Ji-ping , Wang Zi-min , Hu Peng-Cheng , Chen Yu 
Published: August 2022

ObjectiveHerein, we purposed to explore the association of sleep duration with chest pain among adults in US.MethodsThis research work enrolled 13,274 subjects in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. The association of sleep duration with chest pain among adults in US was evaluated by Multivariable logistic regression.ResultsTo elucidate the association, we made adjustments for gender, BMI, diabetes, smoking status, drinking status, race, marital status, annual family income, hyperlipoidemia, Hypertension. Chest pain incidence decreased by 5% [OR = 0.95 (0.93, 0.98), p = 0.0004] for an increase in sleep duration by 1 h. A generalized additive model (GAM) was used to reseal a U-shaped relationship of sleep duration with incident chest pain. When duration of sleep was &lt;6.5 h, chest pain incidence negatively correlated to sleep duration [OR = 0.77 (0.72, 0.82) P &lt; 0.0001]. However, when sleep duration was ≥6.5 h, chest pain incidence rose with escalating sleep duration [OR = 1.07 (1.03, 1.11) p = 0.0014].ConclusionsDuration of sleep was established to be independently linked with an increase in the occurrence of chest pain. Excessive sleep, as much as insufficient sleep, increases the risk of chest pain. Both excessive sleep and insufficient sleep are associated with an increased risk of chest pain.
Association between disability, social support and depressive symptoms in Chinese older adults: A national study
Authors: Tian Gang , Li Rui , Cui Yiran , Zhou Tong , Shi Yan , Yang Wenyan , Ma Yulan , Shuai Jingliang , Yan Yan 
Published: August 2022

ObjectiveDisability and social support can impact depressive symptoms of the elderly. Yet, studies infrequently discuss the moderating role of social support when evaluating the association between disability and depressive symptoms. The purpose of this study was to explore the association between disability, social support, and depressive symptoms among the Chinese elderly, and further examine the moderating effect of social support.Materials and methodsUsing the 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS) data set, we finally selected 9,231 Chinese elderly after screening. The Center for Epidemiologic Studies Depression Scale (CESD-10) was used to evaluate depressive symptoms in the elderly. Disability was measured by basic activities of daily living (B-ADL) and instrumental activities of daily living (I-ADL). Social support included contact with family and friends, sick care, and money received, measured by five self-reported questions. We used multiple linear regression and moderating model to explore the association between disability, social support, and depressive symptoms.ResultsA total of 9,231 patients were included in this study, and approximately 26.75% of the elderly had depressive symptoms. Study found that depressive symptoms were associated with social support (βB−ADL = −0.108, 95% CI: −0.168– −0.047; βI−ADL = −0.098, 95% CI: −0.156– −0.039), βB−ADL (β = 0.296, 95% CI: 0.248−0.343) and I-ADL (β = 0.174, 95% CI: 0.152–0.195). Moreover, the result also showed that social support moderated the effects of B-ADL (βB-ADL*socialsupport = 0.034, 95% CI: 0.014–0.053, F = 11.57, p = 0.001) and I-ADL (βI-ADL*socialsupport = 0.025, 95% CI: 0.017–0.033) on depressive symptoms.ConclusionsThe study suggests that disability and social support can affect depressive symptoms, and social support moderates the effect of disability on depressive symptoms. Therefore, taking effective measures to reduce the elderly disability rate of disability and increase their social support are necessary condition for realizing mental health.
Change of weight status during school age and its association with late adolescent blood pressure: Results from a 15-year longitudinal study in China
Authors: Wang Xijie , Dong Yanhui , Huang Sizhe , Dong Bin , Ma Jun , Liang Wannian 
Published: August 2022

BackgroundChange in obesity risk could be related to shift in high blood pressure (HBP) risk, while individualized influence of weight change on high blood pressure is in need of exploration.MethodsA total of 16,446 children (53.47% boys) and 13,9021 effective annual measurements from 2006 to 2020 were recruited. Children's weight status, both at baseline and endpoint, was categorized as underweight, normal, overweight, and obese according to the age and sex-specific Body Mass Index z scores. HBP at late adolescence was defined with the last two measurements for each child. Populational attributable risk (PAR) of weight trait on HBP risk was calculated.ResultsCompared to children who maintained normal weight during follow-up, staying obese was associated with the highest HBP risk with OR of 6.39 (95% CI: 4.46, 9.15; p &lt; 0.001) and PAR of 28.71% (95% CI: 21.58, 35.54) in boys, and OR of 6.12 (95% CI: 2.80, 13.37; p &lt; 0.001) and PAR of 12.75% (95% CI: 4.29, 21.02) in girls. Returning from obese to normal weight was associated with lowered HBP risk, with ORs of 1.07 (95% CI: 0.69, 1.66; p = 0.771) in boys and 0.73 (95% CI: 0.25, 2.12; p = 0.566) in girls.ConclusionWeight loss program could be effective to reduce HBP risk during school age, while the underlying mechanism needs further exploration.
Derivation and validation of a prediction score for postoperative delirium in geriatric patients undergoing hip fracture surgery or hip arthroplasty
Authors: Shen Jiawei , An Youzhong , Jiang Baoguo , Zhang Peixun 
Published: August 2022

IntroductionPostoperative delirium is a common complication of patients undergoing hip fracture surgery or arthroplasty and is related to decreased survival time and physical function. In this study, we aim to build and validate a prediction score of postoperative delirium in geriatric patients undergoing hip fracture surgery or hip arthroplasty.MethodsA retrospective cohort of geriatric patients undergoing hip fracture surgery or hip arthroplasty was established. Variables of included patients were collected as candidate predictors of postoperative delirium. The least absolute shrinkage and selection operator (LASSO) regression and logistic regression were used to derive a predictive score for postoperative delirium. The accuracy of the score was evaluated by the area under the curve (AUC) of the receiver operating curve (ROC). We used bootstrapping resamples for model calibration. The prediction score was validated in an extra cohort.ResultsThere were 1,312 patients in the derivation cohort, and the incidence of postoperative delirium was 14.33%. Of 40 variables, 9 were identified as predictors, including preoperative delirium, cerebrovascular accident (CVA) with the modified Rankin scale, diabetes with a random glucose level, Charlson comorbidity index (CCI), age, application of benzodiazepines in surgery, surgical delay ≥2 days, creatine ≥90 μmol/L, and active smoker. The prediction score achieved a mean AUC of 0.848 in the derivation cohort. In the validation cohort, the mean AUC was 0.833. The prediction model was well-calibrated in the two cohorts.ConclusionBased on retrospective data, a prediction score for postoperative delirium in geriatric patients undergoing hip fracture surgery or hip arthroplasty was derived and validated. The performance of the scoring system outperformed the models from previous studies. Although the generalization ability of the score needs to be tested in similar populations, the scoring system will enable delirium risk stratification for hip fracture patients and facilitate the development of strategies for delirium prevention.
A Comprehensive Bioinformatic Analysis for Identification of Myeloid-Associated Differentiation Marker as a Potential Negative Prognostic Biomarker in Non-Small-Cell Lung Cancer
Authors: Zhou Min , Chen Yan , Gu Xuyu , Wang Cailian 
Published: August 2022

Objectives: This study aimed to identify a molecular marker associated with the prognosis of non-small-cell lung cancer (NSCLC).Materials and Methods: The RNA sequencing data and clinical information of NSCLC patients were obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO). The weighted gene co-expression network analysis (WGCNA) was used to identify the co-expression gene modules and differentially expressed genes (DEGs) by comparing gene expression between NSCLC tumor tissues and normal tissues. Subsequently, the functional enrichment analysis of the DEGs was performed. Kaplan-Meier survival analysis and the GEPIA2 online tool were performed to investigate the relationship between the expression of these genes of interest and the survival of NSCLC patients, and to validate one most survival-relevent hub gene, as well as validated the hub gene using independent datasets from the GEO database. Further analysis was carried out to characterize the relationship between the hub gene and tumor immune cell infiltration, tumor mutation burden (TMB), microsatellite instability (MSI), and other known biomarkers of lung cancer. The related genes were screened by analyzing the protein-protein interaction (PPI) network and the survival model was constructed. GEPIA2 was applied in the potential analysis of pan-cancer biomarker of hub gene.Results: 57 hub genes were found to be involved in intercellular connectivity from the 779 identified differentially co-expressed genes. Myeloid-associated differentiation marker (MYADM) was strongly associated with overall survival (OS) and disease-free survival (DFS) of NSCLC patients, and high MYADM expression was associated with poor prognosis. Thus, MYADM was identified as a risk factor. Additionally, MYADM was validated as a survival risk factor in NSCLC patients in two independent datasets. Further analysis showed that MYADM was nagetively associated with TMB, and was positively correlated with macrophages, neutrophils, and dendritic cells, suggesting its role in regulating tumor immunity. The MYADM expression differed across many types of cancer and had the potential to serve as a pan-cancer marker.Conclusion:MYADM is an independent prognostic factor for NSCLC patients, which can predict the progression of cancer and play a role in the tumor immune cell infiltration in NSCLC.
Ambiente alimentar e nutricional: estratégias na análise de pequenos e médios territórios
Authors: Cabrini Danielle , Guimarães Natália dos Anjos 
Published: August 2022

Objetivo: Desenvolver classificações dos estabelecimentos que comercializam alimentos, a partir dos índices do instrumento metodológico Nutrition Environment Measures Survey (NEMS); Comparar dois tipos de classificações referentes ao Ambiente Alimentar; Analisar o Ambiente Alimentar através do instrumento previamente aplicado; Verificar a possibilidade de instalação de Pântanos Alimentares e/ou Desertos Alimentares na região dos Pireneus-GO. Métodos: Estudo transversal de caráter quantitativo. Foi selecionado duas formas diferentes de analisar o ambiente alimentar, tendo os estabelecimentos comerciais como ponto de partida. A primeira classificação é por tipo de estabelecimento e a segunda é pelo índice gerado a partir da pontuação do instrumento aplicado em cada estabelecimento. Para comparar os resultados, após analisar os estabelecimentos, desenvolveu-se denominações a fim de atribuir e caracterizar esses estabelecimentos, sendo esses: promotores da saúde, mistos e não promotores da saúde. Resultado: Os resultados pela classificação por Tipo de Estabelecimento definiram os estabelecimentos como misto, em sua maioria. Já a classificação pelo Índice, os resultados apontam a maioria dos estabelecimentos como não promotores da saúde. Além disso, foi realizada a análise do grau de processamento dos alimentos presentes nos referidos estabelecimentos, sendo 33% dos alimentos in natura e 66% dos alimentos ultraprocessados. Conclusão: A classificação pelo Índice foi considerada mais adequada para analisar o ambiente alimentar. Reconhecer as particularidades de cada território é imprescindível para ações de promoção à saúde, promovendo o cuidado integral e a redução das desigualdades existentes.
Correction of Menstrual Cycle Disturbances Due to Post-COVID-19 Infection
Authors: Можейко Л.Ф. , Маркова Е.Д. 
Published: August 2022

В данной статье представлена информация о влиянии новой коронавирусной инфекции на характер менструальной функции у гинекологических пациенток в 2021–2022 гг. и методах коррекции нарушений менструального цикла.Согласно данным, полученным в результате исследования, степень нарушений менструальной функции у обследованных спустя 6 месяцев после перенесенной COVID-19-инфекции пациенток оказалась выше, чем до заболевания, ввиду развития олигоменореи, аменореи и аномальных маточных кровотечений. Полученные в ходе наших исследований результаты согласуются с данными других авторов, указывающих на высокий процент нарушений менструального цикла после перенесенной коронавирусной инфекции. Учитывая высокую значимость указанной проблемы, необходимы дальнейшие углубленные исследования в этом направлении для выяснения ведущих причин таких расстройств.Показана эффективность низкодозированного монофазного комбинированного орального контрацептива белара как в монотерапии, так и при сочетании с лекарственным средством природного происхождения мастодинон в качестве корригирующей терапии нарушений менструального цикла. Установлены положительная динамика снижения проявлений предменструального синдрома, олигоменореи, вторичной аменореи, аномальных маточных кровотечений, альгодисменореи; удобство и безопасность применения лекарственных средств. Подчеркнута целесообразность использования предложенной терапии.
This article provides information on the impact of a new coronavirus infection on the nature of menstrual function in gynecological patients in 2021–2022 years and methods for correcting menstrual irregularities.According to the data obtained as a result of the study, the degree of menstrual dysfunction in patients examined 6 months after suffering COVID-19 infection was higher than before the development of the disease due to the development of oligomenorrhea, amenorrhea and abnormal uterine bleeding. The results obtained in the course of our studies are consistent with the data of other authors, indicating a high percentage of menstrual irregularities after a coronavirus infection. Given the high significance of this problem, further in-depth studies in this direction are needed to elucidate the leading causes of such disorders.The effectiveness of the low-dose monophasic combined oral contraceptive belara has been shown both in monotherapy and in combination with the natural drug mastodinone as a corrective therapy for menstrual irregularities. A positive trend in reducing the manifestations of premenstrual syndrome, oligomenorrhea, secondary amenorrhea, abnormal uterine bleeding, algomenorrhea, convenience and safety of the use of drugs was established. The expediency of using the proposed therapy has been established.
Replicating Digital Audiovisual Archives in the Cloud
Authors: Stolarick Joe 
Published: August 2022

Non-alphanumeric characters in filenames and filepaths can lead to unintended consequences in digital preservation. The New Orleans Jazz & Heritage Foundation Archive conducted simple tests to investigate peculiarities related to this issue that surfaced when preserving their audiovisual assets. This case study resulted in a list of problematic, albeit commonly used, non-alphanumeric characters. It also uncovered significant implications for using proprietary cloud replication software as part of digital preservation workflows.
Reward System dan Turnover Intention bagi Karyawan Milenial
Authors: Kairupan Daniel Joel Immanuel , Kusuma Dheni Indra 
Published: August 2022

Penelitian ini bertujuan untuk menguji pengaruh reward system yang terdiri atas remuneration, cash incentive, supervisor support terhadap turnover intention bagi karyawan milenial. Penelitian ini diharapkan mampu memberikan tambahan bukti empiris untuk memperkuat konsep dan teori mengenai faktor-faktor penentu niat karyawan milenial untuk keluar atau turnover intention yang dipengaruhi oleh faktor remuneration, cash incentive, dan supervisor support serta penerapannya di lingkungan dunia kerja.Penelitian ini menggunakan metode survei dengan sampel adalah karyawan yang tergolong dalam kalangan milenial (tahun kelahiran 1981 sampai 2010). Penelitian ini menjelaskan tentang pengaruh antar variabel dengan menggunakan desain penelitian confirmatory dengan tujuan utama untuk menguji hipotesis yang telah dirumuskan yaitu pengaruh remuneration, cash incentive, supervisor support terhadap intetion to leave bagi karyawan milenial. Penelitian ini juga menggunakan field research dengan kategori penelitian crossectional. Selain itu teknik pengambilan sampel menggunakan non probability sampling tipe purposive sampling.
Investigação-formação-ação no Ensino de Ciências: perspectivas para a constituição do TPACK dos professores
Authors: Bervian Paula Vanessa , Cristina Pansera de Araújo Maria 
Published: August 2022

Apresentamos um recorte da tese de doutorado da primeira autora. Investigamos as compreensões dos professores de Ciências, em formação inicial e continuada, sobre a constituição do conhecimento tecnológico e pedagógico do conteúdo (TPACK), em processos interativos de investigação-formação-ação (IFA) com as tecnologias da informação e comunicação (TIC). A partir do referencial da IFA, framework TPACK e abordagem histórico-cultural, propomos a implementação do modelo Investigação-formação-ação no Ensino de Ciências (IFAEC), articulando formação de professores e desenvolvimento de currículo. Neste artigo, expomos a proposta da IFAEC e perspectivas para a constituição do TPACK dos professores de Ciências por meio das compreensões teóricas resultantes dos dados empíricos e pesquisas da área.