bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Efficacy of Traditional Chinese Medicine in the Treatment of the COVID-19 Pandemic in Henan Province: A Retrospective Study
Authors: Han Ruiting , Xie Yang , Zhao Hulei , Li Bin , Yu Xueqing , Wang Minghang , Li Suyun , Li Jiansheng 
Published: September 2022

Abstract
Background
Since 2020, novel coronavirus disease (COVID-19) has posed serious threats to health systems and led to tremendous economic decline worldwide. Traditional Chinese medicine (TCM) is considered a promising treatment strategy for COVID-19 in China and is increasingly recognized as a key participant in the battle against COVID-19. Clinicians also need accurate evidence regarding the effectiveness of TCM treatments for COVID-19.
Methods
We retrospectively analyzed patients diagnosed with COVID-19 by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in Henan Province from January 19, 2020, to March 2, 2020. the patients were diagnosed with COVID-19 infection confirmed assays, demographic characteristics, clinical data, frequency analysis of Chinese patent medicines (CPMs), Chinese medicine injections (CMIs), evaluation of nucleic acid negative conversion and length of hospitalization, and mortality rates were collected from the electronic medical records of the hospitals in Henan Province.
Results
We analyzed 1245 cases with complete basic information, and extracted information including Chinese herbal decoction, CPMs, and CMIs combined with conventional Western medicine (CWM) used for the treatment of COVID-19. The top 10 CPMs were Lianhua Qingwen capsules, Shuanghuanglian oral liquid, Pudilan Xiaoyan oral liquid, Banlangen granules, Lanqin oral liquid, compound licorice tablets, Bailing capsules, montmorillonite powder, buckwheat flakes, and Diyushengbai. The most frequently used CMIs were Xuebijing, Tanreqing, Reduning, Xiyanping, Yanhuning, Qingkai Ling, and Shenfu injection. TCM combined with CWM improved the patients’ symptom scores for fever, cough, chest tightness, shortness of breath, and fatigue. Nucleic acid negative conversion occurred at 12.06 ± 5.77 d and the average length of hospitalization was 16.56 ± 5.78 d. The mortality rate was approximately 1.76%, which is a reduction in patient mortality.
Conclusion
TCM combined with CWM improved clinical symptoms and reduced hospitalization and mortality rates.
Dynamics of precipitation regions of Turkey: A clustering approach by K-means methodology in respect of climate variability
Authors: Kömüşcü Ali Ümran , Turgu Ertan , DeLiberty Tracy 
Published: September 2022

Abstract
Delineation of homogenous precipitation regions can be rather challenging when considerable spatial variability and seasonality of precipitation exist within a large geographic domain. This study aims to investigate and redefine the spatio-temporal variability of precipitation clusters of Turkey by K-means clustering at different time scales. The monthly precipitation of 234 stations for the 1980–2020 period was included. Five precipitation clusters are identified for the 1980–2020 period, while the clusters varied between four and eight and four and six for the 5- and 10-year sub-periods, respectively. The clustering structures exhibited an indication of certain links to the prominent teleconnection patterns. The monthly precipitation correlated more significantly with Arctic Oscillation (AO) in the Aegean and Mediterranean regions, while North Atlantic Oscillation correlated better with the Eastern and Southeastern Anatolian stations. The variability of the cluster structures is described in association with the coefficient of variation (COV) spatial patterns using the observed station data. At 5- and 10-year subsequent periods, no significant variability in the cluster patterns was observed in the lower COV areas where the monthly precipitation was more uniform throughout the year, while more inter-decadal variability was prominent in the higher COV areas where seasonality in precipitation was more pronounced. Overall, the precipitation regions were not spatially coherent over time, and considerable variability was revealed between different regions of the country.
Assessing the impacts of petrochemical industrial facilities on groundwater in Zubair district
Authors: Yaha Ali Dhafer Abed , Said Md. Azlin Md. , Devi G. Sree Lakshmi , Azamathulla H. M. 
Published: September 2022

Abstract
This study aims to explore the environmental impacts of the solid and liquid wastes of the Petrochemical Industries Complex in the Al-Zubair district (southern Iraq) on the groundwater in the areas surrounding the complex. The waste emerging from the industrial complex is buried in the soil near the factories which has become a major threat to the groundwater of the area. The objectives of the study were to determine the environmental impact of the petrochemical complex and the level of damage caused to neighboring areas as well as to identify the wells most affected by pollution. Field surveys of wells and pollutant disposal sites were conducted in the study area and spatial analysis using the ArcGIS program was used. The results revealed the wells affected by pollution, the type of released pollutants, the extent of their spread and concentration, as well as the factories that produce the most significant percentage of contaminants. Interpretation of spatial information by GIS revealed that liquid chlorine, industrial salts, and ethylene, respectively, had the highest concentrations as pollutants for soil and groundwater, and don't comply with environmental standards. The study also revealed that the chlorine factory, soda, low-density polyethylene granules, and PVC factory are the most polluting factories in the surrounding environment.
COVID-19 and Diabetes Mellitus: Mutual Interplay of Two Diseases
Authors: Krumpolec Patrik , Kodada Dominik , Nyáriová Nikola , Repiská Vanda , Minárik Gabriel 
Published: September 2022

Abstract:
Currently, when the world is fighting against the rapidly spreading pandemic of
COVID-19, the silent epidemic of diabetes should not be set aside. In comparison, while COVID-
19 led to about 6 million deaths in 2021, diabetes caused 6.7 million deaths in the same year. Diabetes
mellitus is a serious risk factor for worse outcomes in COVID-19 patients. Moreover, it
seems that there is a bidirectional relationship between pre-existing diabetes pandemic and the rapidly
spreading COVID-19 pandemic.

:
In this article, we summarize mechanisms by which SARS-CoV-2 infects the host cell and discuss
the bidirectional relationship between diabetes and COVID-19. We also focus on clinical variables
in which diabetic patients differ from non-diabetic patients and which could have promising predictive
value for the course and outcome of diabetic COVID-19 patients’ therapy management.
Pharmacological Perspective of Green Coffee Beans and their Metabolites:
A Review
Authors: Tripathi Shraddha , Mishra Neha , Mishra Neetu 
Published: September 2022

Abstract:
Coffee is the most extensively consumed drink in the world. However, in the last few
years, unroasted coffee seeds, popularly known as green coffee beans (GCB), attracted people
due to its health properties. This review covers pharmacological efficacy, mechanism of action
and bioactive components of green coffee beans. It contains a unique set of polyphenolic
compounds, methylxanthines and diterpenes which are responsible for the astringency, flavour,
smell and taste as well as for its health benefits. Chlorogenic acid, a polyphenolic compound, is
the major bioactive compound in coffee beans which contributes most to the medicinal activities
present in it. The finding reveals the effectiveness of green coffee beans in all parameters of
metabolic syndrome by regulating adipokines. It prevents doxorubicin induced cardiomyocyte
cell death and also has antimutagenic activity on the HeLa cell line and PA-1 cell line. Neuroprotective effect of GCB in degenerative disease was achieved by reducing neuroinflammatory
markers TNF-α (tumor necrosis factor-α) and IL-1β (interleukin-1β). Along with these
properties, GCB has shown some potential antimicrobial, hepatoprotective, cardioprotective and
sunscreen effects, as it contains a high sun protection factor. The findings from this study
conclude that green coffee beans have shown bizarrely several health benefits, but a large
number of trials and intervention are required to establish its medicinal values.
Nanocarriers Based Ocular Therapeutics: Updates, Challenges and Future
Prospectives
Authors: Nagpal Manju , Kaushal Udesh , Kaur Malkiet , Bhuyan Madhusmita , Gounder Kailasam Periyana 
Published: September 2022

Background:
Ocular disorders mainly affect patient’s eyesight and quality of life. Formulation
scientists encounter a hurdle in drug distribution to ocular tissues. Anatomical barriers
(static and dynamic) and physiological barriers, such as nasolacrimal drainage system, blinking
action of eye, and metabolic barriers and efflux pumps, are the principal obstacles to medication
delivery to the posterior and anterior parts. Over the last twenty years, ophthalmic research has
evolved rapidly for the development of innovative, safe, and patient friendly formulations and drug
delivery devices or techniques that may get over these obstacles and sustain drug levels in tissues.

Methods:
Literature from the past ten years has been collected using various search engines, such
as ScienceDirect, J-Gate, Google Scholar, Pubmed, Sci-Hub, etc., and research data have been
compiled according to various novel carrier systems.

Results:
Nanocarriers have been shown to be helpful in overcoming the drawbacks of traditional
ocular dosing forms. Modification of standard topical solutions by both permeability and viscosity
imparters has resulted in breakthroughs in anterior segment medication delivery. Various nanocarriers,
including liposomes, implants, dendrimers, nanosuspensions, nanoparticles, solid lipid
nanocarriers, niosomes and proniosomes have been studied for enhanced penetration and the successful
targeted drug administration to various ocular locations.

Conclusion:
Recently developed nanocarriers for ocular delivery have proved to be cost-effective,
efficacious, safe, and sustained-release carriers, which can be incorporated in suitable dosage
forms.
In this review, the authors have discussed various challenges in ocular drug administration. Various
research reports on advancements in ocular drug delivery based on modified drug delivery
carriers have been analyzed and included. Additionally, marketed formulations and patent literature
on ocular drug delivery have been added as a part to support the review content.
Saúde bucal na gestação: percepções e práticas da gestante na Estratégia Saúde da Família
Authors: Teixeira Gabriel Bastos , Melo Tercia Freire de , Oliveira Hevilla Pereira de , Silva Vanessa Ribeiro da , Silva Italo Emmanoel Silva e , Gonçalves Vanessa Barreiros 
Published: September 2022

A gestação é um período que pode predispor ou agravar algumas alterações bucais, uma vez que é caracterizado por mudanças hormonais, fisiológicas e psicológicas complexas. Apesar disso, o atendimento odontológico pré-natal ainda é negligenciado. Este estudo descritivo, transversal e de natureza quantitativa teve por objetivo analisar percepções e práticas das gestantes que utilizam os serviços de pré-natal de uma Unidade de Saúde da Família (USF) de Itabuna (BA) acerca da saúde bucal durante a gestação, bem como sobre o atendimento odontológico no decorrer do período gestacional. Em 2019, entrevistadores previamente treinados aplicaram questionário único a todas as gestantes residentes na área de abrangência da USF. Utilizou-se o programa estatístico IBM SPSS® Statistics versão 21.0 na análise descritiva. Para verificar a normalidade dos dados foi realizado o teste Kolmogorov-Smirnov, e para o teste de correlação dos dados não-paramétricos foi utilizado o coeficiente de correlação de postos de Spearman, adotando valor de p < 0,05. Dentre as 51 gestantes incluídas neste estudo, 92,2% nunca participaram de atividades educativas sobre saúde bucal na gestação, 76,5% não fizeram nenhum tipo de acompanhamento odontológico pré-natal, 70,6% consideraram que a gestação provoca problemas periodontais e 64,7% afirmaram que a gestação é responsável pelo aparecimento de cáries. Além disso, 94,1% das participantes afirmaram que gostariam de receber mais informações sobre como cuidar melhor da saúde bucal e 64,7% responderam que não existem restrições para a realização dos atendimentos odontológicos durante a gestação. Houve correlação estatisticamente significante entre as condições de saúde e a renda ( = 0,291 e p = 0,038), e entre escolaridade e renda ( = 0,434 e p = 0,01). Ficou evidente a necessidade de uma melhor inclusão da odontologia no cuidado pré-natal da Estratégia de Saúde da Família (ESF), uma vez que o reconhecimento da importância da saúde bucal na gestação, tanto pelos profissionais da equipe quanto pelas mulheres grávidas, é fundamental para um cuidado integral nesse período singular da vida da mulher.
Escore de risco de Framingham em pacientes diabéticos da estratégia de saúde da família
Authors: Fonseca Álvaro Luís Müller , Brito Rosana Andrade , Carvalho Ana Isabel Cezário Conceição de , Amorim Ana Luísa Macedo de , Reis Beatriz Pinto Andrade , Letti Ariel Gustavo 
Published: September 2022

A maioria dos indivíduos com diabetes mellitus também apresenta obesidade, hipertensão arterial sistêmica (HAS) e dislipidemia. Por esse motivo, preconiza-se a Estratificação de Risco de Framingham (ERF), de modo a identificar o risco de desenvolvimento de doenças cardiovasculares (DCV) em dez anos. Este estudo analisa a prevalência de diabetes mellitus para determinar o risco cardiovascular pelo ERF na Estratégia de Saúde da Família (ESF), visando um cuidado integral para a prevenção de DCV. Trata-se de uma pesquisa de corte transversal com população (n = 746) dividida em 150 indivíduos diabéticos (apenas quatro do tipo 1) e 596 não diabéticos a partir de 3.325 prontuários. Foi identificado 57,9% (n = 432) de indivíduos com baixo risco (ERF < 10%); 24,7% (n = 185) em médio risco (ERF 10-20%), e 17,2% (n = 129) em alto risco (ERF > 20%). Os diabéticos de baixo risco representam 23,3% (n = 35/150); 36,6% (n = 55/150) com médio risco e 40% (n = 60/150) com alto risco. Os grupos são significativamente distintos entre si quanto ao ERF (P < 0, 0001) ao comparar os subgrupos de risco (baixo, médio, alto), assim como as taxas de glicemia (P < 0,0001). A prevalência de médio e alto risco aumenta a partir dos 48 anos de idade; o sexo feminino prevalece em todos os níveis de risco e faixas etárias. O risco cardiovascular para diabéticos é 2,5 vezes maior; há impacto aumentado se concomitante com hipertensão, tabagismo, obesidade, sedentarismo e etilismo. O panorama do risco cardiovascular, determinado pelo ERF, é relevante para o uso clínico pela equipe de saúde básica ao lidar com pacientes diabéticos.
DISKURSUS PENGEMBANGAN PARIWISATA SYARIAH DI BALI
Authors: Marbun Saortua 
Published: September 2022

Seiring dengan potensi ekonomi pariwisata syariah global maka para
pemangku kepentingan di Indonesia mengembangkan regulasi, destinasi,
fasilitas pendukung, dan akomodasi pariwisata berdasarkan
prinsip-prinsip syariah Islam. Kebijakan pariwisata syariah tersebut
diimplementasikan pada destinasi-destinasi potensial di Indonesia
termasuk di Pulau Bali. Wacana implementasi pariwisata syariah di Bali
tidak berjalan sesuai dengan harapan bahkan menimbulkan pro dan kontra
di antara pemangku kepentingan pariwisata syariah dan pemangku
kepentingan pariwisata budaya Bali. Pro dan kontra tersebut menarik
untuk diteliti untuk memahami bentuk-bentuk diskursus, faktor-faktor
yang melatarbelakangi penolakan, maupun implikasi-implikasinya. Untuk
memecahkan permasalahan tersebut maka penelitian dilaksanakan dengan
menggunakan metode kualitatif, data dikumpulkan melalui wawancara
mendalam terhadap responden yang dipilih secara purposive dan teknik
snow ball. Data dianalisis dengan teori hegemoni, ideologi dan relasi
kuasa pengetahuan yang digunakan secara eklektik. Berdasarkan hasil
analisis ditemukan bahwa wacana pengembangan pariwisata syariah di Bali
merupakan praktik hegemoni yang melibatkan relasi kekuasaan negara untuk
menanamkan ideologi Islam. Hegemoni pariwisata syariah tersebut tidak
berhasil karena para pemangku kepentingan pariwisata budaya di Bali
melakukan kontra hegemoni secara konsisten. Faktor-faktor yang melatari
kontra hegemoni tersebut adalah konsep pariwisata budaya Bali,
nilai-nilai multikulturalisme dalam pariwisata Bali, dan pemertahanan
identitas etnis Bali. Wacana pariwisata syariah tersebut berimplikasi
terhadap eskalasi praktik politik identitas karena regulasi negara
berpihak pada Islam, menjadi ancaman terhadap pariwisata budaya,
eksistensi tradisi, adat etnis Hindu Bali dan menjadi komoditas politik,
dijadikan rujukan oleh etnis lain di luar Bali, dijadikan sebagai
rambu-rambu untuk pengembangan pariwisata syariah selanjutnya. Oleh
sebab itu disarankan agar pemerintah tidak melanjutkan wacana
implementasi pariwisata syariah di Bali dan memelihara kohesi kebangsaan
dalam keberagaman.
1 Naskah Orasi Ilmiah pada Wisuda XX Universitas Triatma Mulya-Jumat 16
September 2022
Addressing Therapeutic Inertia: Development and Implementation of an Electronic Health Record–Based Diabetes Intensification Tool
Authors: Pantalone Kevin M. , Rajpathak Swapnil , Ji Xinge , Jin Jian , Weiss Tracey , Bauman Janine , Radivoyevitch Tomas , Kattan Michael W. , Zimmerman Robert S. , Misra-Hebert Anita D. 
Published: September 2022

Objective
To assess whether an electronic health record (EHR)-based diabetes intensification tool can improve the rate of A1C goal attainment among patients with type 2 diabetes and an A1C ≥8%.

Methods
An EHR-based tool was developed and sequentially implemented in a large, integrated health system using a four-phase, stepped-wedge design (single pilot site [phase 1] and then three practice site clusters [phases 2–4]; 3 months/phase), with full implementation during phase 4. A1C outcomes, tool usage, and treatment intensification metrics were compared retrospectively at implementation (IMP) sites versus nonimplementation (non-IMP) sites with sites matched on patient population characteristics using overlap propensity score weighting.

Results
Overall, tool utilization was low among patient encounters at IMP sites (1,122 of 11,549 [9.7%]). During phases 1–3, the proportions of patients achieving the A1C goal (&lt;8%) were not significantly improved between IMP and non-IMP sites at 6 months (range 42.9–46.5%) or 12 months (range 46.5–53.1%). In phase 3, fewer patients at IMP sites versus non-IMP sites achieved the goal at 12 months (46.7 vs. 52.3%, P = 0.02). In phases 1–3, mean changes in A1C from baseline to 6 and 12 months (range −0.88 to −1.08%) were not significantly different between IMP and non-IMP sites. Times to intensification were similar between IMP and non-IMP sites.

Conclusion
Utilization of a diabetes intensification tool was low and did not influence rates of A1C goal attainment or time to treatment intensification. The low level of tool adoption is itself an important finding highlighting the problem of therapeutic inertia in clinical practice. Testing additional strategies to better incorporate, increase acceptance of, and improve proficiency with EHR-based intensification tools is warranted.
Addressing Therapeutic Inertia: Development and Implementation of an Electronic Health Record–Based Diabetes Intensification Tool
Authors: Pantalone Kevin M. , Rajpathak Swapnil , Ji Xinge , Jin Jian , Weiss Tracey , Bauman Janine , Radivoyevitch Tomas , Kattan Michael W. , Zimmerman Robert S , Misra-Hebert Anita D 
Published: September 2022

<p> </p>
<p><strong>Objective.</strong> To assess whether an electronic health record (EHR) based diabetes intensification tool can improve the rate of A1C goal attainment among patients with type 2 diabetes and an A1C ≥8%. </p>
<p><strong>Methods. </strong>An EHR-based tool was developed and sequentially implemented in a large, integrated health system using a four-phase, stepped-wedge design (single pilot site [phase 1] and then three practice site clusters [phases 2–4]; 3 months/phase), with full implementation during phase 4. A1C outcomes, tool usage, and treatment intensification metrics were compared retrospectively at implementation (IMP) sites versus nonimplementation (non-IMP) sites with sites matched on patient population characteristics using overlap propensity score weighting. </p>
<p><strong>Results. </strong>Overall, tool utilization was low among patient encounters at IMP sites (1,122 of 11,549 [9.7%]). During phases 1–3, the proportions of patients achieving the A1C goal (<8%) were not significantly improved between IMP and non-IMP sites at 6 months (range 42.9–46.5%) or 12 months (range 46.5–53.1%). In phase 3, fewer patients at IMP sites versus non-IMP sites achieved the goal at 12 months (46.7 vs. 52.3%, <em>P </em>= 0.02). Implementation was not associated with mean A1C improvement from baseline (range −0.88 to −1.08%, IMP sites vs. non-IMP sites <em>P </em>≥0.093). Times to intensification were similar between IMP and non-IMP sites.</p>
<p><strong>Conclusion. </strong>Utilization of a diabetes intensification tool was low and did not influence rates of A1C goal attainment or time to treatment intensification. The low level of tool adoption is itself an important finding highlighting the problem of therapeutic inertia in clinical practice. Testing additional strategies to better incorporate, increase acceptance of, and improve proficiency with EHR-based intensification tools is warranted. </p>
Performance of tungro disease resistant rice lines in Lanrang, South Sulawesi, Indonesia
Authors: Mansur Mansur , Muazam Arif 
Published: September 2022

Efforts to increase rice production and productivity nationally are still being disturbed by plant pest organisms. One of the diseases that have received serious attention is the tungro disease, which has the ability to attack rice plants in endemic areas. The purpose of this study was to investigate the resistance of several rice lines towards the Lanrang South Sulawesi tungro virus inoculum including morphological characteristics. This study was conducted at the Tungro Disease Research station from June to September 2020. A total of 14 lines were tested for resistance compared to the Tukad Petanu, Tukad Balian, Inpari 8 and Tukad Unda lines against the tungro disease. The rice lines were planted in the form of an augmented design consisting of five blocks. Each block contained three test lines and four comparison varieties, the lines were planted in plots (1 × 5) m, with 25 × 25 cm spacings. The results showed that the population of green leafhoppers at the age of 20 DAP and 30 DAP was found to range from 1 to 95 individuals per line/variety, while the incidence of tungro disease was 1.3 to 11.3% in the three test lines, namely STLRG17 15 LR 1, STLRG17 15 LR 2, and STLRG17 108 LR 1. The highest 1000 seed weight was found in the STLRG17 176 LR 2 line (25.1 g) and the lowest was STLRG17 51 LR 1 (17.6 g). The STLRG17 175 LR 1, STLRG17 176 LR, STLRG17 -175-LR-1, STLRG17-28-LR-1, and STLRG17-26-LR-2 5 lines had a fairly good and consistent appearance at 1000 seed weight, higher yield, productive tillers, plant height, and resistance to tungro disease compared to the comparison varieties.