bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does infant sensory responsiveness explain exclusive breastfeeding 6 months after birth? A cohort prospective study
Authors: Freund-Azaria Adi , Bart Orit , Regev Rivka , Bar-Shalita Tami 
Published: October 2022

Abstract

Background
Although exclusive breastfeeding is recommended for the first 6 months of life, breastfeeding rates in most developed countries are low. Sensory responsiveness has been found to interfere with infant and childcare, development, and routines, but have not yet been examined as breastfeeding barrier. The aim of this study was to explore the association between infant sensory responsiveness and exclusive breastfeeding and whether it can predict exclusive breastfeeding cessation prior to 6 months of age.
Methods
In this cohort prospective study participants were 164 mothers and their infants recruited 2 days after birth in a maternity ward between June 2019 and January 2021. At this time, participating mothers completed a demographic and delivery information questionnaire. At 6 weeks after birth, the mothers completed the Infant Sensory Profile2 (ISP2), reporting their infants’ sensory responsiveness in daily activities. At 6 months, infants' sensory responsiveness was assessed using the Test-of Sensory-Functions-in-Infants (TSFI) and the Bayley-Scales-of-Infant-and-Toddler-Development-3rd -Edition was administered. Additionally, mothers provided information about their breastfeeding status and were divided into two groups accordingly: Exclusive breastfeeding (EBF) and non-exclusive breastfeeding (NEBF).
Results
The incidence of atypical sensory responsiveness (mostly of the sensory over-responsivity type) at 6 weeks was twice as high among NEBF infants than EBF infants (36.2% vs. 17%, χ2 = 7.41, p = .006). Significant group differences were found in the ISP2-touch section (F = 10.22, p = .002). In addition, NEBF infants displayed more sensory over-responsivity behaviors than EBF infants in the TSFI-deep touch (F = 2.916, p = .001) and tactile integration subtests (F = 3.095, p < .001), and had lower scores in the adaptive motor functions subtest (F = 2.443, p = .013). Logistic regression modeling revealed that ISP2 at 6 weeks (typical vs. atypical) and TSFI-total score at 6 months predicted 28% of NEBF at 6 months (χ2 = 23.072, p = .010).
Conclusions
Infant atypical sensory responsiveness, predominantly of the sensory over-responsivity type, were found to predict NEBF at 6 months after birth. This study contributes to the understanding of exclusive breastfeeding barriers, highlighting the importance of early identification of sensory over-responsivity in infants. Findings may suggest developing early sensory interventions and providing individualized breastfeeding support tailored to the infant’s unique sensory profile.
Fine-structure of the dehydration boundary diaspore = corundum + H2O as indication of a system of PVT-anomalies
Authors: Mirwald Peter W. 
Published: October 2022

Abstract
The study presents a re-examination of the dehydration reaction diaspore to corundum + H2O between 450° − 600° C in the pressure range 1 to 3 GPa. The high-pressure study bases on differential pressure analysis and simultaneous monitoring of piston displacement performed in a piston-cylinder apparatus. In quasi-isobaric runs the reaction of dehydration and re-hydration is documented by a temperature interval of about 30° width indicating that the reaction is affected by kinetics. In contrast to previous studies which explored the pressure range up to 5 GPa, the re-examined boundary is not presented by a smooth curve, but is structured by pressure anomalies at 1.0, 1.8 and 2.75 GPa. Literature data suggest further anomalies in the pressure range below 1.0 GPa, at 200 and 400 MPa. Comparison with earlier dehydration studies shows a striking similarity in this respect, and suggest a largely temperature independent general system of high-pressure anomalies. Literature examples show that these anomalies are also to be found in other materials of very divers composition.
Glyphosate affects Tetragonisca angustula (Latreille, 1811) (Hymenoptera: Apidae) worker’s locomotion, behavior and biology
Authors: Prado Isabela Sousa , Rocha Agda Alves da , Silva Lais Alves , Gonzalez Vinícius Cunha 
Published: October 2022

Abstract
Declining bee populations diminish pollination services, damaging plant, and agricultural biodiversity. One of the causes of this decline is the use of pesticides. Pesticides with glyphosate as an active ingredient are among the most used pesticides worldwide, being the most used in Brazil. This study determined the 24 and 48 hours LD50 (median lethal dose) of the herbicide glyphosate by ingestion, identified sublethal doses, and investigated its effects on the locomotion and behavior of Tetragonisca angustula workers. The LD50 found indicates that glyphosate is highly toxic to T. angustula. The doses applied, including concentrations found in nature and recommended dosage, caused death, motor changes (decreased speed and tremors), excessive self-cleaning, and disorientation (return to light and stop). These results suggest that this herbicide can negatively affect the pollination activity of T. angustula. Toxicity and sublethal effects evaluation of pesticides on bees contributes to a better understanding of the harmful effects on hives and to adopt strategies to reduce intoxication.
Mathematical modelling for detection of polarity in online social networks using Dempster−Shafer theory and fuzzy functions
Authors: Shekarbaigi Mohsen 
Published: October 2022

Abstract
In this paper, we introduce a mathematical modeling of a relative polarity of onlinesocial networks users. For this purpose, we create a fuzzy model of communities andfinally, we detect the polarity of all users. To achieve this goal, we are faced with theproblem of uncertainty. To solve this problem, we calculated the major methods ofdecision integration, including voting, rank, score, behavior and the Dempster Shafer method. Another initiative of this paper is in it’s ultimate goal which clearly deals with the polarity of a society by a new mathematical modeling. In order to be able toevaluate our proposed method correctly and accurately, we should first implement it and then examine the tools that are produced. Python programming language has been used in Spider software to implement community polarity detection. At each stage we have used the required libraries which have about 3500 lines of useful code. To evaluate the proposed method in Section 2, we implemented our proposed method. The evaluation of the proposed method was done in two ways, first, we compared the second phase of the third phase with different methods of decision integration and after selecting the best method, we reviewed the output results according to the opinions of experts.
In-situ formation of an ultra-low wear boundary tribofilm from carboxylic acid molecules
Authors: Wang Bin , Chang Qiuying , Wang Kai , Li Zhe , Gao Kai 
Published: October 2022

Abstract
This paper describes series of four-ball tribological and atomic force squeezing test results obtained under different contact pressures and sliding speeds (or squeezing speeds) and performed with poly-alpha-olefin suspended 0.5% weight percentage of different types of carboxylic acids. Results indicated that under a confined zone (contact pressures varied from 2.4~3.9 GPa), there is a critical turning speed at which the friction performances of carboxylic acid change dramatically. When the sliding speed exceeds the critical turning speed, carboxylic acid molecules or their incomplete decomposition products would adsorb, deposit, and spread in the friction surface, thus form an island–like aggregate tribofilm with an approximately thickness of 150 nm achieving a super–low wear.
Intraperitoneal injection of 5-azacytidine alleviates nerve injury-induced chronic neuropathic pain in rats: the involvement of DNA methylation in the lumbar spinal cord
Authors: Li Xuan , Liu DeZhao , Dai ZhiSen , You YiSheng , Chen Yan , Lei ChenXing , Lv YouYou , Wang Ying 
Published: October 2022

Abstract

Aims
To investigate the role of DNA methylation in modulating chronic neuropathic pain (NPP), identify possible target genes of DNA methylation involved in this process, and preliminarily confirm the medicinal value of the DNA methyltransferase (DNMT) inhibitor 5-azacytidine (5-AZA) in NPP by targeting gene methylation.
Methods
Two rat NPP models, chronic constriction injury (CCI) and spinal nerve ligation (SNL), were used. The DNA methylation profiles in the lumbar spinal cord were assayed using an Arraystar Rat RefSeq Promoter Array. The underlying genes with differential methylation were then identified and submitted to Gene Ontology and pathway analysis. Methyl-DNA immunoprecipitation quantitative PCR (MeDIP-qPCR) and quantitative reverse transcription-PCR (RT‒qPCR) were used to confirm gene methylation and expression. The protective function of 5-AZA in NPP and gene expression were evaluated via behavioral assays and RT‒qPCR, respectively.
Results
Analysis of the DNA methylation patterns in the lumbar spinal cord indicated that 1205 differentially methylated fragments in CCI rats were located within DNA promoter regions, including 638 hypermethylated fragments and 567 hypomethylated fragments. The methylation levels of Grm4, Htr4, Adrb2, Kcnf1, Gad2 and Pparg, which are associated with long-term potentiation (LTP) and glutamatergic synapse pathways, were increased with a corresponding decrease in their mRNA expression, in the spinal cords of CCI rats. Moreover, we found that the intraperitoneal injection of 5-AZA (4 mg/kg) attenuated CCI- or SNL-induced mechanical allodynia and thermal hyperalgesia. Finally, the mRNA expression of hypermethylated genes such as Grm4, Htr4, Adrb2, Kcnf1 and Gad2 was reversed after 5-AZA treatment.
Conclusion
Increasing methylation is a novel negative regulatory mechanism of target gene expression in chronic NPP. In rats, the intraperitoneal injection of 5-AZA alleviated spinal nociception, an effect accompanied by the reversed expression of hypermethylated genes. Thus, DNA methylation inhibition represents a promising strategy for protection against chronic NPP following nerve injury. Our study lays a theoretical foundation for 5-AZA to become a clinical targeted drug.
Evaluating the performance of flood susceptibility through novel hybrid machine learning approach in tropical plateau basin, India
Authors: Kundu Moumita , Zafor Md Abu , Maity Ramakrishna 
Published: October 2022

Abstract
Floods are catastrophic natural disasters that inundate large areas and cause loss of life and property, property, and crops. The nature and extent of floods are much higher in the lowland plains than in the plateau region through the accumulation and inundation of a higher volume of water from the upland. The flood susceptibility model is essential to identifying the proper inundation zone for socio-cultural, industrial, and human development. This article highlights the flood susceptibility zonation along the Rupnarayan basin in southwestern West Bengal. It carries through the Rarh region, using a new approach by integrating Multi-Criteria Decision Analysis (MCDA) and machine learning (ML) techniques. An integrated model was employed using two or more individual models to obtain the best combination for delineating the flood susceptible zone of the study area. The result reveals that the probability of flood risk is much higher in the lower part of the study area, and in the western part, about 60% of the study area belongs to the moderate to very high class. Cross-validation using the ROC curve implies a good prediction accuracy, and KNN has the highest prediction rate (0.971). Nonetheless, this study recommended adapting several management techniques such as the dam's construction, check dam, embankment, ban on sand mining, change in land-use practices, to resist the severity of flood effect in this study area.
Stilbene Glucoside Ameliorates Symptoms of Attention Deficit Hyperactivity Disorder by Regulating BDNF Signal Pathway and Inhibiting Neuro-inflammation in Spontaneous Hypertensive Rats
Authors: Sun Jichao , Li Weiwei , Zhang Bixia , Chen Songlin , Zhu Wanqing , Xie Sheng , Pang Lihong 
Published: October 2022

Abstract
Background
We investigated the effect of Stilbene on inflammation and the underlying mechanisms in spontaneously hypertensive rats (SHRs).
Methods
Rats were divided into the control group, the model group, the positive group (4.56 mg/kg/day), Stilbene LD group (40 mg/kg), Stilbene MD group (60 mg/kg), and Stilbene HD group (80 mg/kg). The open field test (OFT) and Morris water maze test (MWM) were used to compare the behavior of the rats among the groups, while real-time polymerase chain reaction (PCR) and western blot were used to compare the expression of cytokines in different brain tissues among the groups.
Results
OFT and MWM revealed that stilbene significantly reduced hyperactivity and impulsivity, and improved spatial memory in spontaneously hypertensive rats. Stilbene reduced DHA levels in striatum and hippocampus, but increased the mRNA expressions of AKT1, BDNF, SOS1, PIK3CG, GAB1, and NTRK2, and the protein levels of SOS1, GAB1, AKT1, TrkB, and Kinase P110 beta in prefrontal, striatum, and hippocampus.
Conclusions
Stilbene reduced neuroinflammation and attenuated symptoms of ADHD in SHRs.
Paroxetine mediate macrophage polarization by regulating GRK2-EP4-cAMP-pCREB signaling pathway in treating mice with DSS-induced colitis
Authors: Zhang Jiawei , Zhang Xianzheng , Lu Mingdian , Chang Yan , Wang Qingtong , Tu Jiajie , Wu Huaxun , Wang Chun , Hong Zhongyang , Xiong Maoming , Song Lihua , Wei Wei 
Published: October 2022

Abstract
Objective and design This study aimed to investigate the role of GRK2 in macrophage polarization of ulcerative colitis and to detect weather paroxetine could alleviate the symptoms of DSS-induced colitis in mice by regulating GRK2 translocation to affect macrophage polarization.
Subjects After informed consent, colonic biopsies were obtained from a total of 22 patients with ulcerative colitis group and 22 volunteers who have received colonoscopy as control group. GRK2 heterozygous mice on the C57BL/6J background and WT littermates were used in this study. In vitro experiments were conducted in THP-1 cell.
MethodsLamina propria mononuclear cells (LPMCs) were isolated from surgically resected colonic tissue by using enzymatic technique. THP-1 cells were stimulated by PMA (100 ng/ml) for 48 h to differentiate into macrophages (THP-M). Experimental colitis was induced in mice by administrating 3.5% dextran sodium sulfate for consecutive 7 days. Pathological changes in the colon tissues were assessed by hematoxylin and eosin staining. The levels of infammatory factors, including PGE2, cAMP, IL-1β, and IL-10 were determined by enzymelinked immunosorbent assay. The expression levels of GRK2, EP4, and pCREB proteins were measured by Western blot analysis. The mRNA levels of IRF5 and IRF4 weremeasured by real-time quantitative polymerase chain reaction. The levels of CD68, CD86, CD206 and F4/80 were detected by flow cytometric analysis.
Results
UC patients showed higher PGE2 level and higher M1/M2 ratio than control group patients. In mice, the absence of GRK2 prevented higher disease activity index DAI and higher spleen index. In THP-1, the pIRES-EGFP-GRK2 plasmids transfection enhanced the release of IL-1β and increased the ratio of M1/M2. Paroxetine could influence macrophage polarization by down-regulating EP4/cAMP/pCREB-dependent GRK2 translocation, and alleviated the symptoms in mice with DSS-induced colitis.
Conclusion GRK2 mediates the changes of PGE2-EP4-cAMP-pCREB pathway may influence M2 polarization in LPMCs of UC patients. Paroxetine alleviated the symptoms in mice with DSS-induced colitis and maybe a potential target for UC.
The MYC-YBX1 Circuit in Maintaining Stem-like Vincristine-Resistant Cells in Rhabdomyosarcoma
Authors: Fritzke Madeline , Chen Kenian , Tang Weiliang , Stinson Spencer , Ito Misa , Xu Lin , Chen Eleanor 
Published: October 2022

Abstract
Rhabdomyosarcoma (RMS) is a devastating pediatric soft tissue sarcoma with no effective therapy for relapsed disease. There is limited knowledge on the mechanisms underlying treatment failures. We demonstrated that treatment of RMS cells with vincristine led to an increase of CD133-positive stem-like resistant cells. By single cell RNAseq analysis, MYC and YBX1 were among the top-scored transcription factors in CD133-high expressing cells. CRISPR/Cas9-mediated targeting of MYC and YBX1 reduced stem-like characteristics and viability of the vincristine-resistant cells. MYC and YBX1 exhibited mutual regulation with MYC binding to the YBX1 promoter and YBX1 binding the MYC mRNA. A MYC inhibitor, MYC361i, synergized with vincristine to reduce tumor growth and deplete the stem-like cells in a zebrafish model of RMS. MYC and YBX expression showed positive correlation in RMS patients. High expression of MYC correlated with poor survival. Targeting the MYC-YBX1 axis represents a promising option for improving survival of RMS patients.
It\^o--distribution from Gibbs measure and a comparison with experiment
Authors: bhattacharyay Arijit , Dhawan Abhinav 
Published: October 2022

Abstract
Langevin dynamics of a confined Brownian particle with coordinate--dependent diffusion involves multiplicative noise. Mathematically, equilibrium of such a stochastic system with multiplicative noise is an It\^o--process. However, in physics literature, the process and resulting It\^o--distribution is not considered to represent equilibrium because it is a modified Boltzmann distribution. It\^o--distribution is derived in this paper from Gibbs measure without involving any convention for stochastic integration, hence, no It\^o vs Stratonovich dilemma results. Then, in the light of an existing experiment reported in 1994 by Faucheux and Libchaber, we compare the Boltzmann distribution with the modified one for thermal equilibrium of Brownian particle near confining walls causing coordinate dependence of diffusion. Distribution corresponding to the It\^o--process (modified Boltzmann) is shown to adequately account for the experimental results where the Boltzmann--distribution fails.
Abnormal variations of the four factors in osteoporotic fractures
Authors: Binwang  
Published: October 2022

Abstract
Objective: The classical osteoporotic signaling pathways include the four key factors (LRP5, Runx2, Osterix, and RANKL) influencing the regulation of osteogenesis and osteoclastogenesis. The purpose of this study is to investigate the variations of these four factors in bone specimens associated with fractures of osteoporotic rats. Methods: Osteoporotic rats as osteoporotic group were randomly divided into three groups: group A, group B and group C. Non-osteoporotic rats as control group were divided into three groups: A0, B0 and C0, using the same method. The rats were killed on the third day of fractures in groups A and A0, on the seventh day of fractures in groups B and B0 and on the fourteenth day of fractures in groups C and C0. The bone specimens were taken from the femur. The expression level of each factor in bone specimens was detected using RT-qPCR, Western blotting and immunohistochemistry. Results: LRP5, Runx2 and Osterix expressions were decreased in osteoporotic rat fractures and then increased with the increase in time. The expression of RANKL was elevated in osteoporotic rat bone specimens, and then after that, it keeps going up decreased. Conclusion: The four factors can inform on an ideal interventions in the prevention and management of osteoporosis.
Unveiling knowledge structure and research trends in human libraries: A systematic synthesis of bibliometric, thematic, and content analysis
Authors: Fung-Mei  , Chiao-Min  
Published: October 2022

Abstract
Background It has been more than 20 years since the inception of the human library in 2000. Because no scholar so far has ever conducted a comprehensive review of the development of the human library, our knowledge about human library research is limited.
Purpose This study applied the methodology of systematic review to the literature on human library to understand the development and knowledge structure of the research field.
Scope/Method 46 documents on human library were extracted from Scopus according to PRISMA guidelines. Descriptive statistics were obtained through bibliometric analysis. Thematic analysis identified the research themes. Content analysis examined the knowledge structure of human library research.
Findings This study clarified major characteristics of human library research, such as top articles and journals, most productive authors and countries, and citations, etc. The themes of human library development, diversity, and oral history formed a research strand that focused on the development and operation of human library. The themes of prejudice reduction and inclusion formed another research strand that was interested in the interaction between human books and readers. Finally, the study proposed a comprehensive framework integrating the major themes and facets relating to human library research.
Originality This study conducted a systematic literature review of human library with state-of-the-art of techniques. To the best of the authors’ limited knowledge, to date, the study is the first attempt to combine bibliometric, thematic, and content analysis to study library development in the field of libraries and information science.
CD8+ T cell clonotypes from prior SARS-CoV-2 infection predominate during the cellular immune response to mRNA vaccination
Authors: Ford Emily S. , Mayer-Blackwell Koshlan , Jing Lichen , Sholukh Anton M. , Germain Russell St. , Bossard Emily L. , Xie Hong , Pulliam Thomas H. , Jani Saumya , Selke Stacy , Burrow Carlissa J. , McClurkan Christopher L. , Wald Anna , Holbrook Michael R. , Eaton Brett , Eudy Elizabeth , Murphy Michael , Postnikova Elena , Robins Harlan S. , Elyanow Rebecca , Gittelman Rachel M. , Ecsedi Matyas , Wilcox Elise , Chapuis Aude G. , Fiore-Gartland Andrew , Koelle David M. 
Published: October 2022

Abstract
Almost three years into the SARS-CoV-2 pandemic, hybrid immunity is highly prevalent worldwide and more protective than vaccination or prior infection alone. Given emerging resistance of variant strains to neutralizing antibodies (nAb), it is likely that T cells contribute to this protection. To understand how sequential SARS-CoV-2 infection and mRNA-vectored SARS-CoV-2 spike (S) vaccines affect T cell clonotype-level expansion kinetics, we identified and cross-referenced TCR sequences from thousands of S-reactive single cells against deeply sequenced peripheral blood TCR repertoires longitudinally collected from persons during COVID-19 convalescence through booster vaccination. Successive vaccinations recalled memory T cells and elicited antigen-specific T cell clonotypes not detected after infection. Vaccine-related recruitment of novel clonotypes and the expansion of S-specific clones were most strongly observed for CD8+ T cells. Severe COVID-19 illness was associated with a more diverse CD4+ T cell response to SARS-CoV-2 both prior to and after mRNA vaccination, suggesting imprinting of CD4+ T cells by severe infection. TCR sequence similarity search algorithms revealed myriad public TCR clusters correlating with human leukocyte antigen (HLA) alleles. Selected TCRs from distinct clusters functionally recognized S in the predicted HLA context, with fine viral peptide requirements differing between TCRs. Most subjects tested had S-specific T cells in the nasal mucosa after a 3rd mRNA vaccine dose. The blood and nasal T cell responses to vaccination revealed by clonal tracking were more heterogeneous than nAb boosts. Analysis of bulk and single cell TCR sequences reveals T cell kinetics and diversity at the clonotype level, without requiring prior knowledge of T cell epitopes or HLA restriction, providing a roadmap for rapid assessment of T cell responses to emerging pathogens.