bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression profile of immunophenotypic marker molecules on B-lymphocytes in patients with chronic lymphocytic leukemia at the stages of immunochemotherapy
Authors: Selyutina O. N. , Guskova N. K. , Lysenko I. B. , Konovalchik M. A. 
Published: December 2022

Purpose of the study. To study the expression of immunophenotypic marker molecules on B-lymphocytes of patients with chronic lymphocytic leukemia at the stages of immunochemotherapy while monitoring minimal residual disease.Patients and methods. 20 patients with CLL were examined, who in the period 2019–2022 underwent 6 courses of immunochemotherapy (ICT) in the RB/FCR mode at the National Medical Research Centre for Oncology, Rostov-on-Don. Before, after 3, 6 courses of ICT, bone marrow immunophenotyping was performed by flow cytometry. The data is evaluated in Statistica 13.0.Results. Before treatment, 3 groups of patients were identified depending on the expression of prognostic markers (CD38, ZAP‑70, CD11c, CD25, FMC7). I (2 people) – without expression of CD38, ZAP‑70, CD11c, CD25, FMC7 on tumor B-lymphocytes. II (14 people) – with variable expression of CD25, CD38 (0.4–47.6 % and 0.0–57.5 %, respectively), lack of expression of ZAP‑70, CD11c, FMC7. III (4 people)– with high expression of CD38 (57.5–69.2 %), ZAP‑70 (36.6–48.3 %), CD11c (20.0–96.5 %), CD25 (64.9–92.7 %), FMC7 (13.6–88.6 %). After the 3rd course of ICT, the minimum residual disease (MRD): 0 % in group I, 0.48 ± 0.13 % in group II, 33.5 ± 7.84 % in group III. After the 6th course of ICT MRD: 0 % in group I, 0.42 ± 0.09 % in group II, 33.2 ± 8.07 % in group III. The expression of immunophenotypic markers in groups II and III remained unchanged after 3, 6 courses of ICT. According to the criteria for assessing the response to therapy (IWCLL, 2018), patients of groups I, II after the 6th course of ICT have complete remission, 3 patients of group III have partial remission, 1 patient has stabilization of the process. Preliminary data have been obtained indicating that the absence or increased expression of CD38, CD25, ZAP‑70, CD11c, FMC7 on B-lymphocytes of CLL patients before treatment may predetermine the hematological response to therapy according to RB/FCR regimens.Conclusion. Initially, increased expression of all prognostic antigens simultaneously: CD38, CD25, ZAP‑70, CD11c, FMC7 on the tumor population of B-lymphocytes in patients with CLL is associated with an unsatisfactory response to treatment, which seems promising from the point of view of studying the effect of the analyzed marker molecules on achieving a hematological response at the stages of immunochemotherapy.
Sequential bronchoplastic lobectomies in complex treatment for synchronous bilateral multiple primary non-small cell lung cancer: a rare clinical case
Authors: Kit O. I. , Kharagezov D. A. , Lazutin Yu. N. , Mirzoyan E. A. , Leyman I. A. , Tikhonova S. N. 
Published: December 2022

Today, lung cancer (LC) occupies a special place in the oncological general morbidity among the male population both in Russia and in foreign countries. Despite modern diagnostic capabilities provided for modern physicians, steadily frequent cases of triggering and exclusion are more common in patients older than 60–65 years. Surgery is the main treatment for early-stage non-small cell lung cancer (NSCLC), but as the disease progresses, unfortunately, its effectiveness decreases. The strategy of diagnosing and treating patients with one NSCLC has been developed and worked out for a long time and does not cause any difficulties, but in the presence of two or more tumors, especially when they are located in both lungs, the correct choice of therapy is determined by many additional factors. This article describes the rare use of extended bronchoplastic upper lobectomy as a surgical component of the complex treatment of a patient with bilateral synchronous NSCLC. Based on our own observational data, it can be claimed that the use of modern therapeutic principles in combination with surgical intervention allows achieving satisfactory long-term results in the treatment of patients with primary multiple NSCLC.The interest of the presented observation is based on the fact that it contains a description of a rare and unique application of sequential extended bronchoplastic upper lobectomy as a surgical component of the complex treatment of a patient with bilateral synchronous NSCLC, which we have not found analogues in the literature. We have shown that the consistent use of modern therapeutic modalities makes it possible to achieve satisfactory long-term results in the treatment of a locally advanced disease.
Covariantly constant tensors in Euclid spaces. Elements of the theory
Authors: Мурашкин Евгений Валерьевич , Радаев Юрий Николаевич 
Published: December 2022

В настоящей работе обсуждаются вопросы ковариантного постоянства тензоров и псевдотензоров (в том числе, двухточечных) произвольной валентности и веса в Евклидовом пространстве. Приводятся минимально необходимые сведения из алгебры и анализа псевдотензоров в пространствах Евклида. Выясняются общие условия ковариантного постоянства псевдотензоров. Рассматриваются примеры ковариантно постоянных тензоров и псевдотензоров из многомерной геометрии. Речь, в частности, идет о фундаментальном ориентирующем псевдоскаляре, целые степени которого удовлетворяет условию ковариантного постоянства. Обсуждаются свойства и способы координатного представления тензоров ковариантно постоянных тензоров ипсевдотензоров четвертого ранга. На основе неконвенционального определения полуизотропного тензора четвертого ранга приводится координатное представление в терминах дельт Кронекера и метрических тензоров. Устанавливаются условия ковариантного постоянства полуизотропных тензоров четвертого ранга.
In this paper, we discuss the covariant constancy of tensors and pseudotensors (including two-point ones) of arbitrary valency and weight in Euclidean space. The requisite notions and equations from algebra and analysis of pseudotensors in Euclidean spaces are given. The general conditions for the covariant constancy of pseudotensors are highlighted. Examples of covariantly constant tensors and pseudotensors from multidimensional geometry are considered. In particular, a fundamental orienting pseudoscalar whose integer powers satisfy the condition of covariant constancy is introduced. The properties and methods of coordinate representation of covariantly constant tensors and pseudotensors of the fourth rank are discussed. Based on an unconventional definition of a semi-isotropic tensor of the fourth rank, a coordinate representation in terms of Kronecker deltas and metric tensors is given. Conditions for the covariant constancy of semi-isotropic tensors of the fourth rank are derived.
On stability analysis of a class of three-dimensional system of exponential difference equations
Authors: Khaliq Abdul , Alayachi Haza Saleh , Zubair Muhammad , Rohail Muhammad , Khan Abdul Qadeer 
Published: December 2022

<abstract><p>The boundedness character, persistent nature, and asymptotic conduct of non-negative outcomes of the system of three dimensional exponential form of difference equations were studied in this research:</p>

<p><disp-formula> <label/> <tex-math id="FE1"> \begin{document}$ \begin{eqnarray*} x_{n+1} &amp; = &amp;ax_{n}+by_{n-1}e^{-x_{n}}, \\	\text{ }y_{n+1} &amp; = &amp;cy_{n}+dz_{n-1}e^{-y_{n}},\ \\	z_{n+1} &amp; = &amp;ez_{n}+fx_{n-1}e^{-z_{n}}, \end{eqnarray*} $\end{document} </tex-math></disp-formula></p>

<p>where $ a, \ b, \ c $, $ d, \ e $ and $ f $ are non-negative real values, and the initial values $ x_{-1}, \ x_{0}, \ y_{-1}, \ y_{0}, \ z_{-1}, \ z_{0} $ are non-negative real values.</p></abstract>
Considerações relevantes sobre o tratamento odontológico durante a gestação: revisão de literatura
Authors: Santos Aracely Batista , Oliveira Barbara Milametto de , Santos Bruna Rodrigues dos , Silva Danilo Bombonato de Melo Rios da , Costa Denis Honorato 
Published: December 2022

A gestação é um processo complexo, compreendido por mudanças físicas e psicológicas que afetam profundamente mulheres, sua evolução se dá, na maior parte dos casos, sem intercorrências. Importante: Contudo, o conhecimento científico atual demonstra que qualquer tratamento odontológico pode ser realizado durante a gestação. Nosso objetivo é relacionar a orientação de busca pelo atendimento odontológico durante a gestação desmistificando mitos e medos do tratamento odontológico, apresentando os problemas e as alterações bucais mais comuns bem como o manejo nesse período, incentivando as pacientes gestantes a realizar o pré-natal odontológico, assim, como promover a educação para a realização de procedimentos prevenindo complicações durante e após a gravidez. Para composição desta revisão da literatura narrativa, este artigo utiliza o espaço virtual com o apoio de livros e sites, onde diversas informações relevantes que contribuem para os argumentos e declarações da pesquisa sempre atentando para a segurança da informação e confiabilidade dos dados. Foram realizadas buscas entre agosto e novembro, por materiais científicos relacionados ao diagnóstico e tratamento diferencial durante a gestação, por meio de bases de dados como Pubmed, Google Acadêmico e Revista e-Academica. Consideramos que muitos profissionais na área da odontologia têm demostrado preocupação no atendimento as gestantes, e com isso, as próprias gestantes ficam inseguras, tendo em mente que o tratamento odontológico pode causar anormalidades congênitas ou abortos ao feto, porém qualquer tratamento odontológico pode ser realizado com planejamento, atenção e cuidados necessários.
Decision Tree with Pearson Correlation-based Recursive Feature Elimination Model for Attack Detection in IoT Environment
Authors: Padmashree A. , Krishnamoorthi M. 
Published: December 2022

The industrial revolution in recent years made massive uses of Internet of Things (IoT) applications like smart cities’ growth. This leads to automation in real-time applications to make human life easier. These IoT-enabled applications, technologies, and communications enhance the quality of life, quality of service, people’s well-being, and operational efficiency. The efficiency of these smart devices may harm the end-users, misuse their sensitive information increase cyber-attacks and threats. This smart city expansion is difficult due to cyber attacks. Consequently, it is needed to develop an efficient system model that can protect IoT devices from attacks and threats. To enhance product safety and security, the IoT-enabled applications should be monitored in real-time. This paper proposed an efficient feature selection with a feature fusion technique for the detection of intruders in IoT. The input IoT data is subjected to preprocessing to enhance the data. From the preprocessed data, the higher-order statistical features are selected using the proposed Decision tree-based Pearson Correlation Recursive Feature Elimination (DT-PCRFE) model. This method efficiently eliminates the redundant and uncorrelated features which will increase resource utilization and reduces the time complexity of the system. Then, the request from IoT devices is converted into word embedding using the feature fusion model to enhance the system robustness. Finally, a Deep Neural network (DNN) has been used to detect malicious attacks with the selected features. This proposed model experiments with the BoT-IoT dataset and the result shows the proposed model efficiency which outperforms other existing models with the accuracy of 99.2%.
Faktor-Faktor Yang Mempengaruhi Kegagalan Pemberian Asi Eksklusif Pada Bayi 0-6 Bulan
Authors: Nur Arfan , Supyati Supyati 
Published: December 2022

ASI eksklusif adalah pemberian ASI secara murni tanpa terkontaminasi dengan makanan maupun minuman lainnya yang diterapkan selama 6 bulan pertama kehidupan bayi. ASI diberikan kepada bayi tanpa adanya pendamping makanan lain. Penelitian ini Untuk Mengetahui faktor-faktor yang mempengaruhi kegagalan pemberian ASI eksklusif pada bayi usia 0-6 bulan di UPT Puskesmas Kajuara tahun 2022. Penelitian ini menggunakan metode deskriptif kuantitatif adalah penelitian yang tujuannya untuk menyajikan faktor-faktor yang mempengaruh kegagalan pemberian Asi Eksklusif pada bayi 0-6 bulan dengan cara mendiskripsikan sejumlah variable. Penelitian yang digunakan adalah analisis deskriptif dengan pendekatan cross sectional artinya pengukuran variabel hanya dilakukan satu kali pada satu saat. Populasi dalam penelitian ini adalah semua ibu yang memberikan Asi Eksklusif di lingkup kerja UPT Puskesmas Kajuara Kec. Kajuara Sehingga ditentukan jumlah sampel yaitu sebanyak 25 orang. Hasil penelitian menunjukkan bahwa tidak ada hubungan antara pengetahuan dengan pemberian Asi Ekskl*-sif di UPT Puskesmas Kajuara, Dengan hasi uji chi square test didapatkan p-value=0,123 p<0,05. Ada hubungan Dukungan Keluarrga dengan pemberian Asi Eksklusif di UPT Puskesmas Kajuara, dengan hasil uji chi square test didapatkan p-value=0,001 p>0,0.
Evaluasi Kebijkan Pendidikan
Authors: Prabowo Rizky , Setiawan Farid , Wibowo Joni Mukti , Oktarina Risma , Rahmadia Nurul Anisa 
Published: December 2022

Evaluasi kebijakan pendidikan merupakan sebuah prosedur yang digunakan untuk menilai seberapa besar suatu kebijkan pendidikan memberikan hasil menggunakan pemrbandingan antara tujuan dan target dengan hasil yang diperoleh . prosedurnya harus dikerjakan pada saat implementasi penerapan analisa kebijakan pendidikan, yang bertujuan untuk mengetahui bagaimana kebijakan pendidikan tersebut berjalan apakah berjalan dengan baik atau mendapatkan kendala, diperlukan perubahan atau hanya perbaikan. Selain itu evaluasi kebijakan pendidikan memberikan kejelasan tentang kelebihan dan kekurangan atas kebijakan pendidikan yang diterapkan, kita juga dapat mengetahui segala dampak yang telah ditimbulkan oleh kebijakan pendidikan itu, apakah menimbulkan manfaat atau malah memberikan kerugian, kekacauan dan lain sebagainya. Pada tahap manajemen, proses evaluasi adalah tahapan terakhir dari proses pembuatan kebijakan pendidikan yang dapat melahirkan informasi yang digunakan untuk menyempurnakan kebijakan pendidikan tersebut. Pengukuran terhadap keberhasilan kebijakan pendidikan adalah salah satu prangkat yang sangat penting daidalam suatu kegiatan evaluasi kebijakan pendidikan yang digunakan sebagai pengukuran nilai dan manfaat yang dihasilkan dari kebijakan pendidikan yang diimplementasikan.
Getting Your Laboratory on Track With Neurotrophic Receptor Tyrosine Kinase
Authors: Eyerer Frederick Inglis Rudolf , Bradshaw Georganne , Vasalos Patricia , Laser Jordan Seth , Chang Chung-Che , Kim Annette Sunhi , Olson Damon R. , Paler Ronald Joseph , Rosenbaum Jason N. , Walk Eric E. , Willis Joseph E. , Yao Jinjuan , Yohe Sophia Louise 
Published: December 2022

Context.—Neurotrophic receptor tyrosine kinase (NTRK) fusion testing has both diagnostic and therapeutic implications for patient care. With 2 tumor-agnostic US Food and Drug Administration–approved tropomyosin receptor kinase (TRK) inhibitors, testing is increasingly used for therapeutic decision making. However, the testing landscape for NTRK fusions is complex, and optimal testing depends on the clinicopathologic scenario.Objective.—To compare different NTRK testing methods to help pathologists understand test features and performance characteristics and make appropriate selections for NTRK fusion detection for their laboratory and individual patient specimens.Data Sources.—A literature search for NTRK gene fusions and TRK protein was performed, including papers that discussed treatment, testing methodology, and detection or prevalence of fusion-positive cases.Conclusions.—As standard of care in some tumor types, next-generation sequencing (NGS) panel testing is a cost effective and reliable way to detect a broad range of NTRK fusions. The design of the panel and use of DNA or RNA will affect performance characteristics. Pan-TRK immunohistochemistry may be used as a rapid, less expensive screen in cases that will not undergo routine NGS testing, or on specimens unsuitable for NGS testing. Fluorescence in situ hybridization may be appropriate for low-tumor-content specimens that are unsuitable for NGS testing. Quantitative reverse transcription polymerase chain reaction is best suited for monitoring low-level disease of a specific, previously identified target. This information should help laboratories develop a laboratory-specific NTRK testing algorithm that best suits their practice setting and patients' needs.
Longitudinal Associations Between Use of Mobile Devices for Calming and Emotional Reactivity and Executive Functioning in Children Aged 3 to 5 Years
Authors: Radesky Jenny S. , Kaciroti Niko , Weeks Heidi M. , Schaller Alexandria , Miller Alison L. 
Published: December 2022

ImportanceMobile devices are often used to keep young children occupied or calm, but it is not known whether this practice influences child development.ObjectiveTo examine the longitudinal, bidirectional associations between the parent-reported frequency of using mobile devices to calm young children and children’s executive functioning (EF) and emotional reactivity, testing moderation by child sex and temperament.Design, Setting, and ParticipantsThis prospective cohort study included a community-based convenience sample of English-speaking parents of typically developing children aged 3 to 5 years. The study duration was from August 2018 to January 2020, with baseline (T1), 3-month follow-up (T2), and 6-month follow-up (T3) waves.ExposuresParent-reported frequency of use of mobile devices to calm children when upset (5-point Likert scale).Main Outcomes and MeasuresAt each wave, the child’s EF was assessed with the Behavior Rating Inventory of Executive Function–Preschool Version Global Executive Composite and emotional reactivity with the Child Behavior Checklist Emotional Reactivity subscale. Structural equation models were built to examine cross-lagged associations of the use of devices for calming, EF, and emotional reactivity, testing for moderation by child sex or temperament (Child Behavior Questionnaire–Very Short Form surgency score, median split).ResultsOf 422 eligible parents with data at T1, 375 (88.9%) provided data at T2 and 366 (86.7%) at T3. At baseline, the mean (SD) age of the 422 children was 3.8 (0.5) years, the number of boys in the sample was 224 (53.1%), the number of individuals of non-Hispanic White race and ethnicity was 313 (74.2%), and among the parents, 254 (60.2%) had a college degree or higher. Among the boys, the use of devices to calm at T2 was associated with higher emotional reactivity at T3 (r [standardized regression coefficient] = 0.20; 95% CI, 0.10-0.30), while higher emotional reactivity at T2 had a nonsignificant association with increased device use for calming at T3 (r = 0.10; 95% CI, −0.01 to 0.21). Among children with high temperamental surgency, the use of devices to calm at T2 was associated with increased emotional reactivity at T3 (r = 0.11; 95% CI, 0.01-0.22), while higher emotional reactivity at T2 was associated with increased device use for calming at T3 (r = 0.13; 95% CI, 0.02-0.24).Conclusions and RelevanceThe findings of this study suggest that the frequent use of mobile devices for calming young children may displace their opportunities for learning emotion-regulation strategies over time; therefore, pediatric health care professionals may wish to encourage alternate calming approaches.
Association Between County-Level Natality and Income in the US, 2000-2020
Authors: Turner Nick , Robbins Kendra 
Published: December 2022

ImportanceIt is generally accepted that birth rates are negatively associated with income. However, less is known about the nature and evolution of natality differences between high- and low-income counties and how these differences are associated with the recent decline in the birth rate overall in the US.ObjectiveTo quantify the association between county-level income and natality between 2000 and 2020 and explore how natality inequality is associated with recent nationwide natality declines.Design, Setting, and ParticipantsThis cross-sectional study included all births to US women aged 15 to 44 years among county-year–level observations with at least 100 women of the same age.ExposuresCounty-level median household income rank.Main Outcomes and MeasuresAssociation between natality and income and between natality inequality and national natality trends. Income ventiles were used to rank counties from 1 to 20, with each ventile including 5% of the female population aged 15 to 44 years. A counterfactual simulation was used to estimate natality rates while holding natality inequality constant at its year 2000 value.ResultsA total of 86 679 356 births were aggregated to 65 554 county-year–level observations from 2000 to 2020. The analysis yielded 2 main results. First was the changing nature of inequality. Estimates of the natality income gradient, which reflect the association between county-level natality and county-level income, changed from −0.061 (95% CI, −0.200 to 0.078) in 2000 to −0.572 (95% CI, −0.678 to −0.466) in 2020, reflecting an increase in natality inequality. Intuitively, a negative gradient reflects that natality is lower in higher-income counties compared with lower-income counties. Second, the counterfactual simulation showed that there would have been an additional 3.5 million births (an increase of 4.1%) over the remainder of the study period had natality inequality remained constant at its year 2000 value. While this counterfactual is based on strong assumptions that are unlikely to hold in practice, it suggests that natality may have been higher during this period absent the rise in natality inequality.Conclusions and RelevanceThe findings of this cross-sectional study suggest that natality inequality has increased in recent years and is likely associated with nationwide natality declines. The causes of this inequality remain to be explored in future work.
Electrospun Nanofiber‐Based Synaptic Transistor with Tunable Plasticity for Neuromorphic Computing
Authors: Guo Yizhe , Wu Fan , Dun Guan‐Hua , Cui Tianrui , Liu Yanming , Tan Xichao , Qiao Yancong , Lanza Mario , Tian He , Yang Yi , Ren Tian‐Ling 
Published: December 2022

AbstractBiological synapses are the operational connection of the neurons for signal transmission in neuromorphic networks and hardware implementation combined with electrospun 1D nanofibers have realized its functionality for complicated computing tasks in basic three‐terminal field‐effect transistors with gate‐controlled channel conductance. However, it still lacks the fundamental understanding that how the technological parameters influence the signal intensity of the information processing in the neural systems for the nanofiber‐based synaptic transistors. Here, by tuning the electrospinning parameters and introducing the channel surface doping, an electrospun ZnO nanofiber‐based transistor with tunable plasticity is presented to emulate the changing synaptic functions. The underlying mechanism of influence of carrier concentration and mobility on the device's electrical and synaptic performance is revealed as well. Short‐term plasticity behaviors including paired‐pulse facilitation, spike duration‐dependent plasticity, and dynamic filtering are tuned in this fiber‐based device. Furthermore, Perovskite‐doped devices with ultralow energy consumption down to ≈0.2554 fJ and their handwritten recognition application show the great potential of synaptic transistors based on a 1D nanostructure active layer for building next‐generation neuromorphic networks.