bluuebunny/crossref_metadata_2025_split huggingface dataset:
CGP42112: the full AT2 receptor agonist and its role in the renin–angiotensin–aldosterone system: no longer misunderstood
Authors: Restrepo Yazmin M. , Noto Natalia M. , Speth Robert C. 
Published: November 2022

Abstract
For years, the AT2R-selective ligand CGP42112 has been erroneously characterized as a partial agonist, partly due to its ability to also interact with the AT1R at high concentrations. As late as 2009, it was still being characterized as an antagonist as well. In this perspective/opinion piece, we try to resolve the ambiguity that surrounds the efficacy of this compound by extensively reviewing the literature, tracing its beginnings to 1989, showing that CGP42112 has never been convincingly shown to be a partial agonist or an antagonist at the AT2R. While CGP42112 is now routinely characterized as an AT2R agonist, regrettably, there is a paucity of studies that can validate its efficacy as a full agonist at the AT2R, leaving the door open for continuing speculation regarding the extent of its efficacy. Hopefully, the information presented in this perspective/opinion piece will firmly establish CGP42112 as a full agonist at the AT2R such that it can once again be used as a tool to study the AT2R.
Demand flexibility modelling for long term optimal distribution grid planning
Authors: Bødal Espen Flo , Lakshmanan Venkatachalam , Sperstad Iver Bakken , Degefa Merkebu Z. , Hanot Maxime , Ergun Hakan , Rossi Marco 
Published: November 2022

AbstractOptimisation tools for long‐term grid planning considering flexibility resources require aggregated flexibility models that are not too computationally demanding or complex. Still, they should capture the operational benefits of flexibility sufficiently accurately for planning purposes. This article investigates the sufficiency of an aggregated flexibility model for planning tools by comparing it against a detailed flexibility model. Two different constraint formulations, namely based on recovery period and temporal proximity, were tested to account for post activation dynamics of flexibility resources. The results show that the recovery period based formulation results in excessive demand reduction. The proximity constraint formulation on the other hand results in realistic activation of flexibility resources, which represents an improvement over the base formulation without constraints for post activation dynamics. The results show how a too simple model of the operational behaviour of demand flexibility may overestimate its benefits as an alternative or supplement to grid investments.
Periodic template compensation phase feeding method for phased array antenna
Authors: Zhang Renli , Chen Nuo , Qiu Shuang , Sheng Weixing 
Published: November 2022

AbstractTo minimise the beam‐pointing error caused by the digital phase shifter in phased array antenna systems, a periodic template compensation (PTC) phase feeding algorithm is proposed in this study. In the PTC, the phase quantisation error period of the rounding method in the u‐v dimension is derived as Pu and Pv. Then, the beam‐pointing area is divided into multiple regions with a size of Pu × Pv. In the phase quantisation error period of {u,v}∈{[0,Pu), [0,Pv)}, a sequential phase feeding method is derived to minimise the beam‐pointing error and a compensation matrix template is constructed. The phase feeding code of the PTC is the summation of that of the rounding method and corresponding compensation vector selected periodically from the compensation matrix template. Simulation results show that the maximal beam‐pointing error of the PTC method is 26% of that of the rounding method for a 16 × 16 rectangular array. Azimuth measurement results from a phased array radar system verify the efficiency of the proposed method. Involving only integer multiplication, addition and shift processing, implementing the PTC algorithm in phased array systems is very easy.
Stellar ages, masses, extinctions, and orbital parameters based on spectroscopic parameters ofGaiaDR3
Authors: Kordopatis G. , Schultheis M. , McMillan P. J. , Palicio P. A. , de Laverny P. , Recio-Blanco A. , Creevey O. , Álvarez M. A. , Andrae R. , Poggio E. , Spitoni E. , Contursi G. , Zhao H. , Oreshina-Slezak I. , Ordenovic C. , Bijaoui A. 
Published: November 2022

Context.Gaia’s third data release provides radial velocities for 33 million stars and spectroscopically derived atmospheric parameters for more than 5 million targets. When combined with the astrometric data, these allow us to derive orbital and stellar parameters that are key to understanding the stellar populations of the Milky Way and to perform Galactic archaeology.Aims.We used the calibrated atmospheric parameters, 2MASS andGaia-EDR3 photometry, and parallax-based distances to compute the ages, initial stellar masses, and reddenings for the stars with spectroscopic parameters. We also derived the orbits for all of the stars with measured radial velocities and astrometry, adopting two sets of line-of-sight distances from the literature.Methods.Four different sets of ages, masses, and absolute magnitudes in different photometric bands are obtained through an isochrone fitting method, considering different combinations of input parameters. The reddenings are obtained by comparing the observed colours with those obtained from the isochrone projection. Finally, the orbits are computed adopting an axisymmetric potential of the Galaxy.Results.Comparisons with reference catalogues of field and cluster stars suggest that reliable ages are obtained for stars younger than 9–10 Gyr when the estimated relative age uncertainty is < 50 per cent. For older stars, ages tend to be underestimated. The most reliable stellar type for age determination are turn-off stars, even when the input atmospheric parameters have large uncertainties. Ages for giants and main-sequence stars are retrieved with uncertainties of the order of 2 Gyr when extinction towards the star’s line of sight is less thanAV ≲ 2.5 mag.Conclusions.The catalogue of ages, initial stellar masses, reddenings, galactocentric positions and velocities, as well as the stellar orbital actions, eccentricities, apocentre, pericentre and maximum distance from the Galactic plane reached during their orbits, is made publicly available to be downloaded. With this catalogue, the full chemo-dynamical properties of the extended solar neighbourhood unfold and allow us to better identify the properties of the spiral arms, to parametrise the dynamical heating of the disc, and to thoroughly study the chemical enrichment of the Milky Way.
Efficacy of the specialized scissor-type knife for gastric endoscopic submucosal dissection: a propensity score matched retrospective study
Authors: Tamari Hirosato , Oka Shiro , Kotachi Takahiro , Teshima Hajime , Mizuno Junichi , Fukuhara Motomitsu , Tanaka Hidenori , Tsuboi Akiyoshi , Yamashita Ken , Takigawa Hidehiko , Yuge Ryo , Urabe Yuji , Arihiro Koji , Tanaka Shinji 
Published: November 2022

Abstract
Background and study aims Prevention of bleeding and perforation during gastric endoscopic submucosal dissection (ESD) is important. Scissor-type knives can accurately grasp and incise the targeted tissue using electrosurgical currents, thereby eliminating unexpected incisions. The SB Knife GX, a scissor-type knife specialized for gastric ESD, was released in June 2016 in Japan. The aim of the present study was to evaluate the efficacy and safety of gastric ESD using the SB Knife GX.
Patients and methods A total of 716 patients who underwent gastric ESD at Hiroshima University Hospital between July 2016 and December 2020 were retrospectively reviewed. From these, 671 patients underwent ESD using the IT Knife 2 (IT-2 group), while 45 underwent ESD using an SB Knife GX (SB-GX group). After propensity score matching, the procedure time, specimen size, en bloc and complete resection rates, and intraoperative bleeding, delayed bleeding, and perforation rates were evaluated.
Results No significant differences were observed in mean procedure time (SB-GX group: 115 ± 165 min; IT-2 group: 95 ± 61 min; P  = 0.82) and en bloc and complete resection rates between the two groups. Intraoperative bleeding rates were significantly lower in the SB-GX group than in the IT-2 group (18 % vs. 40 %; P  = 0.01), and there were no differences in delayed bleeding (4 % vs. 4 %) or perforation (0 % vs. 4 %) between the two groups.
Conclusions The SB Knife GX was proven to be useful for control of intraoperative bleeding during gastric ESD, although the procedure time tended to be longer.
Determining Clinically Meaningful Outcomes after Isolated Acetabuloplasty in the Context of Age and Arthritic Severity: A Retrospective Review of Prospectively Collected Data
Authors: Huyke-Hernández Fernando A. , Samagh Sanjum P. , Hassan Mahad M. , Tjong Vehniah K. , Terry Michael A. 
Published: November 2022

AbstractOutcomes after isolated acetabuloplasty in mixed-type femoroacetabular impingement (FAI) patients can be favorable but are relatively unknown in the context of clinically important outcome variables (CIOVs) such as minimum clinically important difference and patient acceptable symptomatic state (PASS). Prognostic roles of age and osteoarthritis (OA) in hip arthroscopy are still unclear. We aimed to evaluate isolated acetabuloplasty outcomes including CIOVs while controlling for age and arthritis.This was a retrospective review of prospectively collected data. We analyzed patients with available 1-year follow-up for Patient-Reported Outcome Measurement Information System (PROMIS) scales for Physical Function (PF) and Pain Interference (PI). Patients were divided into two age groups (< 40 years old vs. ≥ 40 years old) and two Outerbridge arthritis grade groups (grade 0–I vs. grade II–IV). Demographic, radiographic, and surgical characteristics as well as revision surgeries and complications were extracted. Our outcome was the proportion of patients that achieved values over literature-reported CIOV thresholds for PROMIS-PF and PROMIS-PI.A total of 63 patients of 96 eligible (65.6%) had minimum 1-year data. Characteristics were comparable between patients aged younger than 40 and 40 and over as well as between grade 0 to I and grade II to IV patients. Overall, average PROMIS-PF and PROMIS-PI scores improved. Approximately 81.0% of patients reached values over CIOV threshold (71.4% for PROMIS-PF, 54.0% for PROMIS-PI), with 44.4% reporting these outcomes for both PROMIS-PF and PROMIS-PI. Approximately 30.2% of patients reported values over PASS threshold for both PROMIS-PF and PROMIS-PI, with 25.4% of patients achieving values above all CIOV thresholds. Only one patient required revision surgery. When evaluating the effect of age while controlling for OA severity and vice versa, there were no significant outcome differences (p > 0.615). When comparing patients reporting values above CIOV threshold versus those that did not, there were no differences in age (41.2 ± 13.0 [37.7, 44.8] vs. 45.9 ± 13.2 [38.4, 53.4], p = 0.265) or Outerbridge grade distribution (p = 0.177).This study uses CIOVs to describe clinically meaningful isolated acetabuloplasty outcomes for mixed-type FAI. Most patients over a wide spectrum of age and OA achieved favorable clinically meaningful outcomes following surgery. Isolated acetabuloplasty can alleviate symptomatology in mixed-type FAI patients on a case-by-case basis.
Older adults’ experiences of a community wellness program (Connect 60+) that focused on physical activity and social connections: a qualitative exploratory study
Authors: Weselman Tammy , Naseri Chiara , Vaz Sharmila , Beilby Janet , Garswood Luke , O’Connell Hilary , Hill Anne-Marie 
Published: November 2022

Background Being physically active and socially connected is positively associated with healthy aging. Older adults living in the community may be at risk of social isolation and reduced physical activity, especially in recent times due to COVID-19. There are many programs that offer opportunities for evidence-based physical activity or social connection; however, there is a lack of programs that include both. The objective of this study was to explore the lived experience of older adults who participated in Connect 60+ – a program that promoted exercise and social activities – delivered from a community hub that could be attended either in person or online. Methods A qualitative study that used descriptive phenomenology was conducted. A purposive sample of 13 older adults (age ≥65 years) was recruited to take part in semistructured telephone interviews to discuss barriers and enablers to program engagement. Data were analysed using thematic analysis. Results The overarching theme was that participating in Connect 60+ was an enjoyable and encouraging experience for participants. The program enabled them to increase their physical activity and build social connections within their community. The main themes that enabled engagement were: (1) an enabling program design, (2) developing new connections in the community, and (3) experiencing motivation to engage. A few barriers were identified, including difficulties connecting online and lack of male attendance. Conclusions Wellness programs delivered in community hubs may facilitate older adults to increase their engagement in both physical and social activity. The program appeared to impact positively on participants’ motivation, with some participants reporting that they had sustained their behaviour changes since program completion. To address identified barriers, easy to use online technology is recommended, and strategies to promote male attendance.
Structuring of the epigeal fauna in restoration of Brazilian semiarid forest in the short term
Authors: Gomes Juvenal Martins , Cabreira Wilbert Valkinir , Lima Sandra Santana de , Camara de Souza Rodrigo , dos Santos Raissa Nascimento , Feliciano Ana Licia Patriota , Marangon Luiz Carlos , Pereira Marcos Gervasio 
Published: November 2022

Context The Caatinga biome, located in the Brazilian semiarid region, has few remnants of riparian forest. Thus, it is essential to know the effectiveness of strategies aimed at forest recovery. Aims The objective of this study was to investigate the use of the epigeal fauna as a bioindicator tool of soil quality and ecosystem sustainability to determine the best native forest restoration strategy in the Caatinga in Belém do São Francisco, Pernambuco, Brazil. Methods In areas previously dominated by Prosopis juliflora (Sw.) DC., three treatments were installed: conventional planting of native species (P), planting of native species in islands (applied nucleation, N), and natural regeneration (NR). These restoration treatments were compared with an area of high P. juliflora dominance (PJ). Epigeal fauna were captured in two periods of the year (wet and dry seasons) using pitfall traps in a completely randomised design. We estimated the total abundance, richness, diversity, and evenness, as well as the trophic guilds of the epigeal fauna. Key results The epigeal fauna organisms were distributed in 22 taxonomic groups. The Saprophagous Diplopoda group was exclusive to PJ. The Predator Pseudocorpionida group was not observed in the NR area in any period. Cluster analysis revealed more dissimilarity of the NR with the other areas. Conclusions In the short term (less than 2 years), P increased the diversity and richness of the epigeal fauna and promoted better structuring of the Microphagous/Saprophagous (Entomobryomorpha, Poduromorpha, and Symphypleona) trophic guild, while NR promoted better structuring of the Herbivorous (Auchenorryhncha and Heteroptera) and Saprophagous/Predator (Formicidae and Coleoptera) trophic guilds. Implications In the short term, conventional planting benefited the epigeal fauna due to the high diversity of planted species.
On the geometric phase for Majorana and Dirac neutrinos
Authors: Capolupo A , Giampaolo S M , Hiesmayr B C , Lambiase G , Quaranta A 
Published: November 2022

Abstract
We analyze the geometric phase for neutrinos and we demonstrate that the geometric invariants associated with transitions between different neutrino flavors, for Majorana neutrinos, are not left unchanged by rephasing transformations and are sensitive to the nature of neutrinos. The dependence of geometric invariants on the Majorana phase cannot be eliminated by a charged lepton rephasing transformation. By considering kinematic and geometric approach we also demonstrate that the Majorana phase is relevant in the projective Hilbert space. Geometric invariants can therefore be used as tools to distinguish between Dirac and Majorana neutrinos.
Dynamic interplay between thionine and DNA under carbon ion irradiation: a real-time first-principles study
Authors: Deng Zun-Yi , Hu Zhihua , Feng Hong-Jian 
Published: November 2022

Abstract
Understanding the interactions between deoxyribonucleic acid (DNA) and photosensitizer under ion irradiation benefits the development of aptasensors, DNA biosensors and cancer diagnosis. Using real-time time-depended density functional theory, by simulating high-energy C ion passing through DNA with poly(dG)·poly(dC) sequence and that with embedded thionine (3,7-diamino-5-phenothiazinium, TH), we compared the electronic stopping power (ESP), evolution of the structure and charge, and absorption spectrum. TH inserting leads the increase in space charge density, a larger electron de-excitation and a larger ESP, but the speed corresponding to the maximum ESP is almost same. When C ion passes through TH–DNA, the structure of TH slightly changes and there still exists noncovalent interaction between TH and DNA, but the absorption coefficient depends on the electron occupied state of TH when the ion passes through. These results indicate that at low radiation doses, TH still can be a DNA detector, although its response wavelength and intensity have been slightly changed, and provide a theoretical reference to improve the possible application of phenothiazine dye in DNA biosensor under ion irradiation.
Magnetoresistance reversals and anomalous Hall effect in Mn3SnC and effects of carbon deficiency
Authors: Huang Dan , Li Hang , Xi Xuekui , Gao Jianrong , Lau Yong-Chang , Wang Wenhong 
Published: November 2022

Abstract
The transport behavior of Mn3SnC and Mn3SnC0.8 compounds was investigated. Positive magnetoresistance (MR) and an anomalous Hall effect (AHE) are observed for each compound near respective Curie temperature, T
C. The positive MR is reversed during cooling from T
C but is reentrant at low temperature. A 20% carbon deficiency of Mn3SnC0.8 enlarges the positive MR at T
C and shifts the temperatures for MR reversals. Ferromagnetic (FM) resonance measurements reveal that the MR reversals are related to the competition between FM and antiferromagnetic components of Mn atoms in each compound. A sign change of the Hall resistivity is observed during cooling of Mn3SnC but not for Mn3SnC0.8. A scaling analysis suggests that the AHE in each compound is mostly due to an intrinsic contribution and that the intrinsic contribution is decreased by the carbon deficiency in Mn3SnC0.8.
Effect of nonlinear electrodynamics on shadows of slowly rotating black holes*
Authors: Tang Jiuyang , Liu Yunqi , Qian Wei-Liang , Yue Ruihong 
Published: November 2022

Abstract
In this study, we investigate the effect of nonlinear electrodynamics on the shadows of charged, slowly rotating black holes with the presence of a cosmological constant. Rather than the null geodesic of the background black hole spacetime, the trajectory of a photon, as a perturbation of the nonlinear electrodynamic field, is governed by an effective metric. The latter can be derived by analyzing the propagation of a discontinuity of the electromagnetic waveform. Subsequently, the image of the black hole and its shadow can be evaluated using the backward ray-tracing technique. We explore the properties of the resultant black hole shadows of two different scenarios of nonlinear electrodynamics, namely, the logarithmic and exponential forms. In particular, the effects of nonlinear electrodynamics on the optical image are investigated, as well as the image's dependence on other metric parameters, such as the black hole spin and charge. The resulting black hole image and shadow display rich features that potentially lead to observational implications.
-gravity in the context of dark energy with power law expansion and energy conditions*
Authors: Manna Goutam , Panda Arijit , Karmakar Aninda , Ray Saibal , Islam Md. Rabiul 
Published: November 2022

Abstract
The objective of this work is to generate a general formalism of

gravity in the context of dark energy under the framework of K-essence emergent geometry with the Dirac-Born-Infeld (DBI) variety of action, where

is the familiar Ricci scalar,

is the DBI type non-canonical Lagrangian with

, and ϕ is the K-essence scalar field. The emergent gravity metric (

) and the well known gravitational metric (

) are not conformally equivalent. We have constructed a modified field equation using the metric formalism in

-gravity incorporating the corresponding Friedmann equations into the framework of the background gravitational metric, which is of Friedmann-Lemaître-Robertson-Walker (FLRW) type. The solution of the modified Friedmann equations have been deduced for the specific choice of

, which is of Starobinsky-type, using the power law expansion method. The consistency of the model with the accelerating phase of the universe has been shown when we restrict ourselves to consider the value of the dark energy density as

, which indicates that the present universe is dark-energy dominated. Graphical plots for the energy density (ρ), pressure (p), and equation of state parameter (

) with respect to (w.r.t.) time (t) based on parametric values are interestingly consistent with the dark energy domination theory, and hence the accelerating features. We also highlight the corresponding energy conditions and constraints of the

theory with a basic example.