bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-dependent estimation of origin-destination matrices using partial path data and link counts
Authors: Vahidi Milad , Shafahi Yousef 
Published: November 2022

Abstract
The precise estimation of time-varying demand matrices using traffic data is an essential step for planning, scheduling, and evaluating advanced traffic management systems (ATMS). This paper presents an innovative method (based on the least squares approach) to deal with the inherent complexities in estimating the dynamic characteristics of changing demand flow over time and considering congestion conditions. The time-dependent Origin-Destination (OD) demand matrices of the network are estimated by exploitation of the received partial paths data from an automated vehicle identification (AVI) system, and vehicle counts data from loop detectors on a subset of the links. A traffic assignment approach based on partial paths is embedded into the measurement equations of the least squares model. For all time intervals, the relation between the variable aspects of congestion (the temporal and spatial distribution of the OD traffic flows) is established by their variance-covariance matrices. The LSQR algorithm, an iterative algorithm that is logically equivalent to the conjugate gradient method, is employed for solving the proposed least squares problem. Numerical examples performed on three different approaches (only link counts data, only partial path flows data, and both of them) show that using the variance-covariance matrices is more precise for estimating time-dependent OD matrices. The Sioux Falls network is presented to examine the solution algorithm’s effectiveness and the model’s main ideas. This paper reports the features of the discussed model based on synthetic data as proof of concept that using partial path flows significantly improves the results for solving time-dependent OD matrices estimation problems.
Migration-agglomeration-lockup of metal particles in zeolite for ultra-stable propane dehydrogenation catalysts
Authors: Zhu Haibo , Xu Zhikang , Gao Mingbin , Yue Yuanyuan , Bai Zhengshuai , Yuan Pei , Ye Mao , Fornasiero Paolo , BASSET JEAN , Bao Xiaojun 
Published: November 2022

Abstract

Propane dehydrogenation (PDH) over Pt catalyst operated in a moving-bed mode is becoming the dominant process for the on-purpose production of propylene worldwide1-3. Sintering and coking deactivations of Pt catalysts, which greatly decrease the durability and efficiency of this scarce and costly noble metal, are the most challenging issues for the sustainable development of the PDH process4. Even after over half a century of efforts, the development of long-term durable Pt catalysts that are feasible for more economic and efficient fixed-bed operation remains as a formidable task5-10. Herein we report a strategy to modulate the migration-agglomeration-lockup of Pt particles in zeolite silicalite-1 (S-1) for synthesizing highly sintering- and coking-resistant (Pt-Sn2)2@S-1 PDH catalysts. It is found that the migration of Pt-Sn2 clusters in S-1 crystals during the PDH reaction leads to a competition between intra-crystalline agglomeration and external-surface agglomeration of Pt-Sn2 clusters. We show that, when the b-axis length of S-1 crystals is longer than 2 μm, the intra-crystalline agglomeration becomes dominant over the external-surface agglomeration, resulting in the formation of ultra-stable (Pt-Sn2)2@S-1 in which the (Pt-Sn2)2 dimers are securely locked in the channels of S-1 crystals. The long-term durability (4500 hours or about 6 months on stream without perceptible deactivation tendency) of (Pt-Sn2)2@S-1 is at least three orders of magnitude higher than that of the best catalyst reported, which is expected to bring about a breakthrough in revolutionizing the moving-bed operation of the current PDH process to fixed-bed operation. We anticipate that modulating metal migration-agglomeration-lockup within zeolite can act as a general strategy for the synthesis of durable noble metal catalysts, which is beneficial to greatly maximizing the service lifetime of noble metals in industry application11-15.
Synergetic-PI controller based on genetic algorithm for DPC-PWM strategy of a multi-rotor wind power system
Authors: Benbouhenni Habib , Gasmi Hamza , Colak Ilhami , Bizon Nicu , Thounthong Phatiphat 
Published: November 2022

Abstract
This work designs a powerful new nonlinear method using synergetic control (SC), proportional-integral (PI) controller, and genetic algorithm (GA) for multi-rotor wind energy (MRWE) conversion systems, whereby an asynchronous generator is used to achieve optimal energy extraction. The direct power control (DPC) is used based on the proposed synergetic-PI-GA (SPI-GA) method to control the generator in a MRWE system, where this new nonlinear technique is used to achieve stable control characteristic under random changes in wind speed and to provide great robustness against modeling uncertainties. Moreover, the pulse width modulation (PWM) technique is used to control the generator inverter due to its simplicity and ease of implementation. In this proposed DPC-SPI-GA method, we need to measure current and voltage to estimate the active power and the reactive power. Also, inner loops are not used in this proposed DPC-SPI-GA method as is the case in the field-oriented control (FOC) method, where the proposed system in this work is characterized by an integrated structure. Three different tests are proposed to study and verify the behavior of the designed DPC-SPI-GA strategy compared to the DPC technique.
Feasibility of oral doxycycline as first-line therapy for conjunctival mucosa-associated lymphoid tissue lymphoma
Authors: Choi Se Hyun , Yang Min Kyu , Kim Tae Min , Choi Hyuk Jin 
Published: November 2022

Abstract
Objectives: To investigate the long-term outcomes of oral doxycycline as first-line treatment in patients with conjunctival extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) MALT lymphoma.
Methods: In this case series, the medical records of 67 patients with conjunctival MALT lymphoma who received doxycycline as their primary treatment and were followed up for at least 5 years were retrospectively reviewed. Progression-free survival (PFS) was analyzed at 3, 5, and 10 years after the initial doxycycline treatment. A Cox proportional hazards model was used to assess the independent risk factors for progression.
Results: After the initial treatment, 25 patients(37.3%) achieved complete response, 8 patients(11.9%) achieved partial response, 30 patients(44.8%) showed stable disease, and 4 patients(6.0%) showed disease progression. The median PFS in all patients was 168 months, and the 3-, 5- and 10-year PFS rates for all patients were 70%, 65%, and 62%, respectively. No further progression was observed 6 years after the initial doxycycline treatment. Older age and TNM stage T1c were significant risk factors for the time to progression in the multivariate Cox regression analysis (p<0.05). Additional doxycycline (> 2 cycles) showed no benefit. There were no serious adverse events associated with doxycycline therapy, and most patients were successfully salvaged by the current best treatment modalities.
Conclusion: In this case series, oral doxycycline treatment showed acceptable long-term PFS with minimal complications. Especially in patients with stage T1a or T1b conjunctival MALT lymphoma, first-line doxycycline treatment could be considered under close monitoring for at least 6 years.
Optimal therapy for concomitant EGFR and TP53 mutated non-small cell lung cancer: A real- world study
Authors: Sun Haiyan , Ren Peng , Chen Yongzi , Lan Lan , Yan Zhuchen , Yang Yinli , Wang Bin , Wang Cong , Li Yanwei , Li Ling , Zhang Yu , Li Yanyang , Wang Zuolin , Pan Zhanyu , Jiang Zhansheng 
Published: November 2022

Abstract
Background
Concomitant TP53 mutation results in poor prognosis in patients with epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) treated with tyrosine kinase inhibitors (TKIs) and may preferentially benefit from a combination regimen. The present study aims to compare the benefits of EGFR-TKIs and its combination with antiangiogenic drugs or chemotherapy in patients with NSCLC harboring EGFR and TP53 co-mutation in a real-life setting.
Methods
This retrospective analysis included 124 patients with advanced NSCLC having concomitant EGFR and TP53 mutations, who underwent next-generation sequencing prior to treatment. Patients were classified into the EGFR-TKI group and combination therapy group. The primary endpoint of this study was progression-free survival (PFS). Kaplan–Meier (KM) curves were plotted to analyze PFS, and log-rank test was used to compare differences between groups. Univariate cox regression analysis was performed on the risk factors associated with survival.
Results
The combination group included 72 patients who received the regimen of EGFR-TKIs combined with antiangiogenic drugs or chemotherapy, while the EGFR-TKI monotherapy group included 52 patients treated with TKI only. The median PFS was significantly longer in the combination group than in the EGFR-TKI group (18.0 months; 95% confidence interval [CI]: 12.1–23.9 vs. 7.0 months; 95% CI: 6.1–7.9; p < 0.001) with greater PFS benefit in TP53 exon 4 or 7 mutations subgroup. Subgroup analysis showed a similar trend. The median duration of response was significantly longer in the combination group than in the EGFR-TKI group. Patients with 19 deletions or L858R mutations both achieved a significant PFS benefit with combination therapy versus EGFR-TKI alone.
Conclusions
Combination therapy had a higher efficacy than EGFR-TKI alone for patients with NSCLC having concomitant EGFR and TP53 mutations. Future clinical trials are needed to determine the role of combination therapy for this patient population.
Research Capacity, Motivators and Barriers to Conducting Research Among Healthcare Providers in Tanzania’s Public Health System: A Mixed Methods Study
Authors: Kengia James Tumaini , Kalolo Albino , Barash David , Chwa Cindy , Hayirli Tuna Cem , Kapologwe Ntuli A. , Kinyaga Ally , Meara John G. , Staffa Steven J. , Zanial Noor , Alidina Shehnaz 
Published: November 2022

Abstract
Background: Building and strengthening health research capacity in low- and middle-income countries is essential to achieving universal access to safe, high-quality healthcare. It can enable healthcare workers to conduct locally relevant research and apply findings to strengthen their health delivery systems. However, lack of funding, experience, know-how, and weak research infrastructures hinders their ability. Understanding research capacity, engagement, and contextual factors that either promote or obstruct research efforts by healthcare workers can inform national strategies aimed at building research capacity.
Methods: We used a convergent mixed-methods study design to understand research capacity and engagement of healthcare workers in Tanzania’s public health system, including the barriers, motivators, and facilitators to conducting research. Our sample included 462 randomly selected healthcare workers from 45 facilities. We conducted surveys and interviews to capture data in five categories: 1) research capacity; 2) research engagement; 3) barriers, motivators, and facilitators; 4) interest in conducting research; and 5) institutional research capacity. We assessed quantitative and qualitative data using frequency and thematic analysis respectively; we merged the data to identify recurring and unifying concepts.
Results: Respondents reported low experience and confidence in quantitative (34% and 28.7% respectively) and qualitative research methods (34.5% and 19.6% respectively). Less than half (44%) of healthcare workers engaged in research. Engagement in research was positively associated with: working at a District Hospital or above (p=0.006), having a university degree or more (p=0.007), and previous research experience (p=0.001); it was negatively associated with female sex (p=0.033). Barriers to conducting research included lack of research funding, time, skills, opportunities to practice, and research infrastructure. Motivators and facilitators included a desire to address health problems, professional development, and local and international collaborations. Almost all healthcare workers (92%) indicated interest in building their research capacity.
Conclusion: Individual and institutional research capacity and engagement among healthcare workers in Tanzania is low, despite high interest for capacity building. We propose a four-fold pathway for building research capacity in Tanzania through 1) high-quality research training and mentorship; 2) strengthening research infrastructure, funding, and coordination; 3) implementing policies and strategies that stimulate research engagement; and 4) strengthening local and international collaborations.
Corticosteroid in anti-inflammatory treatment of pediatric acute myocarditis: a systematic review and meta-analysis
Authors: Yao Qi , Zhan Shanshan 
Published: November 2022

Abstract
Background. To evaluate the efficacy of corticosteroids in anti-inflammatory treatment of pediatric acute myocarditis.
Methods. We searched PubMed, Embase and Cochrane library and included studies before October 2022 for clinical trials, observational studies and retrospective studies which reported on children with acute myocarditis treated with corticosteroid anti-inflammatory therapy. The quality of the clinical trials was assessed by Jadad score as an exclusion criterion.
Results. This systematic review included 6 studies involving 604 pediatric patients with acute myocarditis. Corticosteroid therapy was not associated with reduced risk of mortality due to acute myocarditis (P = 0.53; RR = 0.87; 95% CI = 0.58 to 1.33) compared to anti-failure treatment. There was a significant improvement in pediatric patients’ left ventricular function measured by left ventricular ejection fraction in the group on corticosteroid anti-inflammatory treatment (P = 0.0009; MD = 11.93%; 95% CI = 4.87% to 18.99%). No conclusion can be drawn due to the high heterogeneity in meta-analyses of risk of getting to a clinical endpoint (death or heart transplantation) and changes in left ventricular end-diastolic diameter (LVEDD).
Conclusions. Corticosteroid anti-inflammatory therapy in pediatric acute myocarditis patients showed no significant improvement in reducing the risk of mortality, but showed significant improvement in LVEF.
Title: Evaluation of antimicrobial activity of the crude extract of three Bauhinia species from the Brazilian Amazon
Authors: Oliveira Fabyanne , Carvalho Bruna , Frade Paula Cristina Rodrigues , Cruz Jorddy Neves , Junior Helio Longoni Plautz , de Lima Raylson Coelho , Lameira Osmar Alves , Lameira Christian , Costa Fernando Augusto Miranda da 
Published: November 2022

Abstract

The Bauhinia ungulata, Bauhinia variegata, and Bauhinia purpurea are commonly used in folk medicine. However, few studies have investigated its antimicrobial potential. This study evaluated the in vitro antibacterial effect of crude extracts from leaves of B. ungulata, B. variegata and B. purpurea, in addition to identifying the class of constituents. The evaluation of antimicrobial activity was determined using the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) methods against American Type Collection Culture (ATCC) strains of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes and Klebsiella pneumoniae. All crude extracts showed similar phytochemical analysis with saponins and tannins and bactericidal activity against all the bacterial strains. The extract of B. variegata stood out with a MIC of 3.6 µg/mL against P. aeruginosa. From this perspective, the extracts of Bauhinia spp. showed promising microbial activity and should be further investigated for the development of antibacterial agents of natural origin.
Assessment of the Effect of Climate Change and Human Activities on Vegetation Dynamics and its Vulnerability
Authors: Rahimabadi Pouyan Dehghan , Azarnivand Hossein 
Published: November 2022

Abstract
It is necessary to evaluate the impacts of climate change and human activities on vegetation dynamics. The purpose of this study is to assess the linkage of vegetation cover and climate change and distinguish the contribution of climate change and human activities on vegetation and its vulnerability in Namak Lake basin, Iran. For this purpose, changes in the Enhanced Vegetation Index (EVI) in association with Standardized Precipitation Evapotranspiration Index (SPEI) during 2000–2019 were analyzed. Then, the roles of climate change and human activities on vegetation vulnerability were assessed in various Land Use Land Cover (LULC) classes using the residual analysis and Probability of Vegetation Vulnerability Index (PVVI). The results indicated that vegetation cover was mainly dependent on short-term climatic changes and their correlation decreased with increasing time scale of SPEI. It reflected that short-term water availability was vital for vegetation growth. Also, the sparse vegetation cover was mainly more vulnerable to climate change. Residual analysis showed that the vegetation dynamics was intensively attributed to the climate change, so that climate change affected vegetation cover in 78.96% of the basin, while 15.58% was affected by human activities and 5.46% was affected by both factors. The value of PVVI in the regions affected by climatic change was the highest (55.99), in the regions affected by human activities it was lower (50.40), and in the regions affected by both factors was between the other two numbers (50.93). The results can provide useful recommendations for designing the restoration plans in arid and semi-arid areas.
Enhanced Radiosensitivity and Chemo-radiation efficacy of Nasopharynx Carcinoma via Dual-targeted SPION@Polymer Hybrid Nanosensitizer
Authors: Pan Yue , Ding Yuxun , Xiao Xiaohui , Bai Lu , Yang Bowen , Zeng Lingli , Lin Guanghui , Xie Lisi , Li Lei , Duan Xiaohui , Shen Jun , Zhou Jianhua 
Published: November 2022

Abstract
Cisplatin-based nanoparticles show great potential for enhancing the effect of nasopharynx carcinoma (NPC) therapy but are still limited by their low radiation sensitization and poor tumor targeting ability. Herein, an ingenious design of multifunctional SPOIN@polymer hybrid nanosensitizers (SPHNs) with enhanced radio-sensitization and dual-targeting capability is described. SPHNs have a core-shell structure, in which radiosensitizer superparamagnetic iron oxide particles (SPION) and cis-platinum (CDDP) are encapsulated in RGD-conjugated amphiphilic block copolymers. These unique structures endow SPHNs with outstanding radio-sensitization and tumor targeting abilities. When combined with X-ray, SPHNs showed great potential in promoting the apoptosis of NPC cells (CNE-1 cells) in vitro. Unexpectedly, RNA-seq and KEGG enrichment analyses indicated that the PI3K-Akt and TNF signaling pathways were closely related to the molecular mechanism of SPHNs in chemoradiotherapy. Gene set enrichment analysis (GSEA) revealed that SPHNs plus X-ray treatment down regulated translation initiation pathways and cytoplasmic translation pathway. By using the combination of radiation and chemotherapy, SPHNs can achieve a remarkable inhibition of tumor growth in vivo, making this nanotechnology become a general platform for the chemo-radiation therapy of NPC in the future.
Single-cell profiling identifies a CD8bright CD244bright Natural Killer cell subset that reflects disease activity in HLA-A29-positive birdshot chorioretinopathy.
Authors: Nath Pulak , Maclean Mary , Nagarajan Vijay , Lee Jung , Yakin Mehmet , Kumar Aman , Nadali Hadi , Schmidt Brian , Kaya Koray Dogan , Kodati Shilpa , Young Alice , Caspi Rachel , Kuiper Jonas , Sen Nida 
Published: November 2022

Abstract

MHC-I-opathies are inflammatory conditions strongly associated with HLA class I genes. The striking association with HLA class I suggests involvement of T cells, whereas natural killer (NK) cell involvement remains largely unstudied. Here we show that HLA-A29-positive birdshot chorioretinopathy patients have a skewed NK cell pool containing expanded CD16-positive NK cells which produce more proinflammatory cytokines. These NK cells contain populations that express the HLA class I restricted antigen CD8A which display gene signatures indicative of high cytotoxic activity (IGFBP7, MYOM2, and LINC00996), and signaling through NK cell receptor CD244 (SH2D2A and SH2D1B). Long-term monitoring of a cohort of birdshot chorioretinopathy patients with active disease identified a population of CD8bright CD244bright NK cells, which rapidly declined to normal levels upon clinical remission following successful treatment. Collectively, these studies implicate CD8bright CD244bright NK cells in the sight-threatening MHC-I-opathy, birdshot chorioretinopathy.
Comparative developmental genomics of sex-biased gene expression in early embryogenesis across mammals
Authors: Richardson Victorya , Engel Nora , Kulathinal Rob J 
Published: November 2022

Abstract
Background: Mammalian gonadal sex is determined by the presence or absence of a Y chromosome and the subsequent production of sex hormones contributes to secondary sexual differentiation. However, sex chromosome-linked genes encoding dosage-sensitive transcription and epigenetic factors are expressed well before gonad formation and have the potential to establish sex-biased expression that persists beyond the appearance of sex hormones. Here, we apply a comparative bioinformatics analysis on published single-cell datasets from mouse and human during very early embryogenesis–from two-cell to preimplantation stages–to characterize sex-specific signals and to assess the degree of conservation among early-acting sex-specific genes and pathways.
Results: Clustering and regression analyses of gene expression across samples reveal that sex initially plays a significant role in overall gene expression patterns at the earliest stages of embryogenesis. In addition, gene expression signals from male and female gametes during fertilization may still be present. Although these transcriptional sex effects rapidly diminish, the sex-biased expression of epigenetic enzymes has the potential to establish sex-specific patterns that persist beyond preimplantation. Sex-biased genes appear to form sex-specific protein-protein interaction networks across preimplantation stages in both mammals. While the distribution of sex-differentially expressed genes (sexDEGs) in early embryonic stages is similar in mice and humans, the genes involved are generally different. Non-negative matrix factorization (NMF) on male and female transcriptomes generated clusters of genes with similar expression patterns across sex and developmental stages, including post-fertilization, epigenetic, and preimplantation ontologies conserved between mouse and human.
Conclusions: This comparative study uncovers much earlier than expected sex-specific signals in mouse and human embryos that pre-date hormonal signaling from the gonads. These early signals are diverged with respect to orthologs yet conserved in terms of function with important implications in the use of genetic models for sex-specific disease.