bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term outcome of consecutive case series of congenital isolated agenesis of corpus callosum
Authors: Lanna M. , Scelsa B. , Cutillo G. , Amendolara M. , Doneda C. , Balestriero M. , Faiola S. , Casati D. , Spaccini L. , Cetin I. 
Published: March 2022

ABSTRACTObjectiveTo describe the long‐term outcome of children with prenatally diagnosed isolated complete agenesis of the corpus callosum (cACC).MethodsIn this single‐center case series, we reviewed retrospectively the charts of fetuses referred to our fetal therapy unit from January 2004 to July 2020 for a suspected anomaly of the corpus callosum (CC). Cases with prenatally diagnosed isolated cACC were included. Fetal karyotype and comparative genomic hybridization microarray of amniotic fluid, in addition to fetal magnetic resonance imaging, were offered to all pregnant women with a diagnosis of fetal CC malformation. The surviving children were enrolled in the neurodevelopmental follow‐up program at our institution, which included postnatal magnetic resonance imaging, serial neurological examinations and neurodevelopmental evaluations with standardized tests according to age. Families living in remote areas or far from our institution were offered a structured ad‐hoc phone interview.ResultsA total of 128 pregnancies with fetal CC malformation were identified (mean gestational age at diagnosis, 24.5 (range, 21–34) weeks), of which 53 cases were diagnosed prenatally with apparently isolated cACC. Of these, 12 cases underwent termination of pregnancy, one resulted in intrauterine demise at 24 weeks of gestation and 13 cases were lost to follow‐up. Of the remaining 27 children, one was excluded due to an associated chromosomal anomaly (8p21.3q11.21 mosaic duplication) diagnosed after birth, which could have been detected prenatally if the parents had consented to amniocentesis. In the 26 children included in the analysis, neurodevelopmental follow‐up was available for a median of 3 (range, 1–16) years. Three (11.5%) infants had severe neurodevelopmental impairment, two of which were diagnosed postnatally with a genetic syndrome (Mowat–Wilson syndrome and Vici syndrome) that would not have been diagnosed prenatally. Seven (26.9%) children had mild neurodevelopmental impairment and 16 (61.5%) had normal neurodevelopmental outcome. The Full‐Scale Intelligence Quotients of the three children with severe neurodevelopmental impairment were 50, 64 and 63, respectively, while that of the remaining children was in the normal range (median, 101; range, 89–119).ConclusionsIn 88% of the children with cACC included in this study, neurodevelopment was not severely impaired. However, long‐term follow‐up is recommended in all cases of congenital isolated cACC to recognize subtle neurodevelopmental disorders as early as possible. © 2022 International Society of Ultrasound in Obstetrics and Gynecology.
The efficacy of a nutritional supplement containing green‐lipped mussel, curcumin and blackcurrant leaf extract in dogs and cats with osteoarthritis
Authors: Corbee Ronald Jan 
Published: March 2022

AbstractBackgroundOsteoarthritis is a common disease in dogs and cats, and the search for novel treatment options is needed. The combination of green‐lipped mussel, curcumin and blackcurrant leaf extract has to date not been studied in dogs and cats.ObjectivesThe aim of this study was to test the effect of a supplement containing green‐lipped mussel (Perna canaliculus), curcumin (Curcuma longa) and blackcurrant (Ribes nigrum) leaf extract on locomotion and behaviour in client‐owned dogs and cats suffering from mild to moderate osteoarthritis.MethodsTo this end, 32 dogs and 16 cats were enrolled in a double‐blinded, randomised, crossover, placebo‐controlled trial for 10 weeks in cats and 16 weeks in dogs. Outcome parameters were the Helsinki Chronic Pain Index (HCPI) by pet owners in dogs and cats, Canine OsteoArthritis Staging Tool (COAST) by a veterinarian in dogs and Force Plate Analysis (FPA) in 18 dogs.ResultsIn dogs, the COAST improved significantly in the supplement group compared to baseline but was not different than the placebo group. In cats, the ability to groom, activity level, playfulness and walking up the stairs improved in the supplement group. No differences were found on HCPI scores and FPA in dogs. Several non‐responders were noted in both species, which were irrespective of the stage of osteoarthritis.ConclusionsOverall, the supplement had only partial positive effects in client‐owned dogs and cats with mild to moderate osteoarthritis. Further research with a larger sample size and longer duration is needed to expand these findings.
Ein pessimistischer Blick nach vorn? Die Erwartungen der Österreicher*innen an die Entwicklung der Lebensumstände nach Corona
Authors: Moosbrugger Robert , Prandner Dimitri 
Published: March 2022

ZusammenfassungDer Beitrag widmet sich der Frage, wie sich die Lebensumstände auf persönlicher und gesellschaftlicher Ebene in den nächsten Jahren entwickeln werden. Konkret wird diskutiert, in welchen Bereichen von einer Verschlechterung ausgegangen wird und in welchen nicht? Welchen Einfluss hat dabei die wahrgenommene Gefahr durch Corona? Welche Determinanten für das Ausmaß von Zukunftspessimismus lassen sich darüber hinaus finden? Als empirische Grundlage werden Daten aus demAustrian Corona Panel Project 2020 (ACPP)herangezogen. Die Corona-Krise führte zu einem Anstieg an Zukunftspessimismus. Je weiter der Bezugspunkt von den persönlichen Lebensumständen entfernt ist, desto pessimistischer fallen Erwartungen hinsichtlich deren Entwicklung in den nächsten Jahren aus. Es zeigen sich Unterschiede nach soziodemografischen Merkmalen und der wahrgenommenen gesundheitlichen, vor allem aber wirtschaftlichen Gefahr durch Corona. Zukunftserwartungen geben auch Auskunft über das wahrgenommene Potenzial einer Gesellschaft, Krisen zu bewältigen. Auch in der Krise scheint zu gelten: Wenn es gelingt, eine als gerecht wahrgenommen Verteilung von gesellschaftlichen Gütern zu gewährleisten und Vertrauen in Institutionen besteht, dann schlagen sich die aktuellen krisenbedingten Disruptionen weniger in pessimistischen Zukunftserwartungen nieder.
Die Bedeutung von Religiosität und Spiritualität in Krisenzeiten
Authors: Höllinger Franz , Aschauer Wolfgang 
Published: March 2022

ZusammenfassungEine wichtige Funktion der Religion im Verlauf der Menschheitsgeschichte liegt darin, die Menschen bei der Bewältigung existenziell bedrohlicher Lebenssituationen zu unterstützen. In einem prosperierenden Staat wie Österreich, mit einem funktionierenden Gesundheitssystem und einem etablierten Wohlfahrtsstaat, in dem die meisten relativ gut gegen ökonomische Risiken abgesichert sind, könnte die gegenwärtige Krise aber nur bedingt mit einer stärkeren Bedeutung von Religiosität und Spiritualität einhergehen. Andererseits könnten sich religiös und spirituell aktive Personen sowohl in der Krisenbewältigung, als auch in solidarischen Einstellungen von nicht religiösen Personen unterscheiden. Vor diesem Hintergrund werden im Beitrag anhand des Austrian Corona Panel Projekts (ACPP) vier Fragestellungen untersucht? 1) Ist die Religiosität in der Zeit der Covid-19-Pandemie im Vergleich zu den vorhergehenden Jahren in der Gesamtgesellschaft tendenziell gestiegen? 2) Führt eine starke gesundheitliche oder ökonomische Betroffenheit durch die Corona-Krise zu einer höheren Bedeutung von Religion und Spiritualität? 3) Wie wirken sich Religiosität und Spiritualität auf das emotionale Wohlbefinden, die Lebenszufriedenheit und die Strategien der Krisenbewältigung (Coping-Strategien) aus? 4) Unterscheiden sich religiöse, spirituelle und nicht religiöse Menschen in Hinblick auf ihre Haltung zur staatlichen Krisenpolitik, den Umgang mit den sozialen Distanzregelungen sowie dem Solidarverhalten gegenüber Menschen, die besonders von der Krise betroffen sind?
Umwelt in der Krise. Einstellungen zu Klimawandel und Umweltbesorgnis sowie Bereitschaft zu umweltbewusstem Verhalten in Krisenzeiten
Authors: Wardana Rebecca , Klösch Beate , Hadler Markus 
Published: March 2022

ZusammenfassungDieser Beitrag widmet sich der Frage, wie sich die Einstellungen zum Klimawandel, die Umweltbesorgnis und die Bereitschaft zu umweltbewusstem Handeln im Laufe der Corona-Krise in der österreichischen Bevölkerung entwickelt haben. In Anbetracht der unmittelbaren Bedrohung durch die Covid-19-Pandemie und deren direkte Auswirkungen auf die österreichische Bevölkerung (Herunterfahren der Wirtschaft, Einschränkungen des sozialen Lebens usw.) liegt die Vermutung nahe, dass das Thema Umwelt in den Hintergrund rückte. Um dies zu untersuchen, wurden drei voneinander unabhängige Datensätze (OeNB,Values in Crisis und Polarization in Public Opinion) herangezogen. Die drei Datensätze sind in ihrer Erhebungszeit vor, während und nach der ersten Covid-19-Welle einzuordnen. Lineare Modelle zeigen, dass sowohl die Umweltbesorgnis als auch die Bereitschaft zu umweltbewusstem Verhalten in der Krise gesunken sind, wenngleich nur in den Ballungsräumen Wien, Niederösterreich und Steiermark. Andererseits stieg die Wahrnehmung der negativen Auswirkungen des Klimawandels an. Im Verlauf der Krise zeigt sich zudem, dass trotz der sinkenden Umweltbesorgnis diese dennoch der stärkste Prädiktor zu intentionsorientiertem Umweltverhalten bleibt und nach Ende der ersten Welle einen noch stärkeren Erklärungswert liefert als zuvor.
A first look at the function space for planar two-loop six-particle Feynman integrals
Authors: Henn Johannes , Peraro Tiziano , Xu Yingxuan , Zhang Yang 
Published: March 2022

Abstract
Two-loop corrections to scattering amplitudes are crucial theoretical input for collider physics. Recent years have seen tremendous advances in computing Feynman integrals, scattering amplitudes, and cross sections for five-particle processes. In this paper, we initiate the study of the function space for planar two-loop six-particle processes. We study all genuine six-particle Feynman integrals, and derive the differential equations they satisfy on maximal cuts. Performing a leading singularity analysis in momentum space, and in Baikov representation, we find an integral basis that puts the differential equations into canonical form. The corresponding differential equation in the eight independent kinematic variables is derived with the finite-field reconstruction method and the symbol letters are identified. We identify the dual conformally invariant hexagon alphabet known from maximally supersymmetric Yang-Mills theory as a subset of our alphabet. This paper constitutes an important step in the analytic calculation of planar two-loop six-particle Feynman integrals.
Vacuum structure of Alternative Left-Right Model
Authors: Frank Mariana , Majumdar Chayan , Poulose Poulose , Senapati Supriya , Yajnik Urjit A. 
Published: March 2022

Abstract
We investigate an Alternative Left-Right Model (ALRM) with SU(2)L as well as SU(2)R gauge groups, but unlike the traditional left-right symmetric models (LRSM) is not symmetric under the exchange of the fermion content. Interestingly, it can be embedded in E6, while its low energy Higgs structure resembles the LRSM, involving Higgs doublets χL,R and one Higgs bidoublet Φ. We analyze the scalar potential and the vacuum structure of the theory analytically to ensure the stability of scalar potential via bounded from below (BFB) and copositivity criteria, accompanied by a numerical study. We establish the necessary criteria for electric charge-preserving vacua, yielding constraints on various coupling parameters of the theory. Finally we obtain constraints on the parameters of the model from collider data on the masses of the Higgs scalars.
Summing inflationary logarithms in nonlinear sigma models
Authors: Miao S. P. , Tsamis N. C. , Woodard R. P. 
Published: March 2022

Abstract
We consider two nonlinear sigma models on de Sitter background which involve the same derivative interactions as quantum gravity but without the gauge issue. The first model contains only a single field, which can be reduced to a free theory by a local field redefinition; the second contains two fields and cannot be so reduced. Loop corrections in both models produce large temporal and spatial logarithms which cause perturbation theory to break down at late times and large distances. Many of these logarithms derive from the “tail” part of the propagator and can be summed using a variant of Starobinsky’s stochastic formalism involving a curvature-dependent effective potential. The remaining logarithms derive from the ultraviolet and can be summed using a variant of the renormalization group based on a special class of curvature-dependent renormalizations. Explicit results are derived at 1-loop and 2-loop orders.
Post-Minkowskian radial action from soft limits and velocity cuts
Authors: Bjerrum-Bohr N. Emil J. , Planté Ludovic , Vanhove Pierre 
Published: March 2022

Abstract
We consider gravitational massive scalar-scalar scattering from unitarity and demonstrate how intermediate soft graviton behavior and the concept of extracting classical physics from localization of integrands on velocity cuts devise an efficient extraction scheme for computing the classical post-Minkowskian radial action perturbatively. We demonstrate the computational efficiency by deriving the scattering amplitudes in the probe regime to the fifth post-Minkowskian order in arbitrary dimensions.
Monotonicity-based regularization for shape reconstruction in linear elasticity
Authors: Eberle Sarah , Harrach Bastian 
Published: March 2022

AbstractWe deal with the shape reconstruction of inclusions in elastic bodies. For solving this inverse problem in practice, data fitting functionals are used. Those work better than the rigorous monotonicity methods from Eberle and Harrach (Inverse Probl 37(4):045006, 2021), but have no rigorously proven convergence theory. Therefore we show how the monotonicity methods can be converted into a regularization method for a data-fitting functional without losing the convergence properties of the monotonicity methods. This is a great advantage and a significant improvement over standard regularization techniques. In more detail, we introduce constraints on the minimization problem of the residual based on the monotonicity methods and prove the existence and uniqueness of a minimizer as well as the convergence of the method for noisy data. In addition, we compare numerical reconstructions of inclusions based on the monotonicity-based regularization with a standard approach (one-step linearization with Tikhonov-like regularization), which also shows the robustness of our method regarding noise in practice.
Vorhersage von schweren Blutungsereignissen bei Patienten mit peripherer arterieller Verschlusskrankheit: Der OAC3-PAD-Risikoscore
Authors: Behrendt Christian-Alexander , Rother Ulrich , Uhl Christian , Goertz Hartmut , Stavroulakis Konstantinos , Gombert Alexander ,   die Kommission PAVK und DFS der DGG e. V.
Published: March 2022

ZusammenfassungObwohl Patient:innen mit einer peripheren arteriellen Verschlusskrankheit (PAVK) aufgrund ihres Komorbiditäts- und Risikoprofils ein insgesamt erhöhtes Blutungsrisiko aufweisen, standen bisher keine validierten Werkzeuge zur Vorhersage des Blutungsrisikos zur Verfügung. Erschwerend kommt hinzu, dass viele randomisierte und kontrollierte Studien zu antithrombotischen Therapien Patient:innen mit erhöhtem Blutungsrisiko ausgeschlossen haben. Anhand von Routinedaten der Krankenkasse wurde mittels Verfahren des maschinellen Lernens ein pragmatisches Vorhersagemodell entwickelt und intern validiert. Mit dem OAC3-PAD-Risikoscore wurden acht Variablen identifiziert, die das Risiko von schweren Blutungsereignissen innerhalb eines Jahres nach stationärer Behandlung der PAVK vorhersagen können. Dieser Risikoscore kann dabei helfen, eine patientenzentrierte Risiko-Nutzen-Abwägung durchzuführen, um das maximale Potenzial aus den verfügbaren antithrombotischen Therapiestrategien zu schöpfen.
Cancer and cardiovascular-related perceived risk in a diverse cancer center catchment area
Authors: Pinheiro Laura C. , Soroka Orysya , Razon Dominic , Ramos Rosio , Antoine Francesse , Dannenberg Andrew J. , Safford Monika , Peterson Stephen J. , Tamimi Rulla M. , Nanus David M. , Phillips Erica 
Published: March 2022

Abstract
Purpose
Despite cancer and cardiovascular disease (CVD) sharing several modifiable risk factors, few unified prevention efforts exist. We sought to determine the association between risk perception for cancer and CVD and engagement in healthy behaviors.

Methods
Between May 2019 and August 2020, we conducted a cross-sectional survey of adults ≥ 40 years residing in Brooklyn neighborhoods with high cancer mortality. We considered one’s perceived risk of cancer and CVD compared to age counterparts as the primary exposures. The primary study outcome was a weighted health behavior score (wHBS) composed of 5 domains: physical activity, no obesity, no smoking, low alcohol intake, and healthy diet. Modified Poisson regression models with robust error variance were used to assess associations between perceived risk for cancer and CVD and the wHBS, separately.

Results
We surveyed 2448 adults (mean [SD] age, 61.4 [12.9] years); 61% female, 30% Non-Hispanic White, and 70% racial/ethnic minorities. Compared to their age counterparts nearly one-third of participants perceived themselves to be at higher CVD or cancer risk. Perceiving higher CVD risk was associated with an 8% lower likelihood of engaging in healthy behaviors (RR 0.92; 95% CI 0.86–0.99). Perceiving greater cancer risk was associated with a 14% lower likelihood of engaging in healthy behaviors (RR 0.86; 95% CI 0.79–0.95). The association between cancer risk and wHBS attenuated but remained significant (aRR 0.90; 95% CI 0.82–0.98) after adjustment.

Conclusion
Identifying high-risk subgroups and intervening on shared risk behaviors could have the greatest long-term impact on reducing CVD and cancer morbidity and mortality.
Cardiac Cell Therapy with Pluripotent Stem Cell-Derived Cardiomyocytes: What Has Been Done and What Remains to Do?
Authors: Selvakumar Dinesh , Reyes Leila , Chong James J. H. 
Published: March 2022

Abstract
Purpose of Review
Exciting pre-clinical data presents pluripotent stem cell-derived cardiomyocytes (PSC-CM) as a novel therapeutic prospect following myocardial infarction, and worldwide clinical trials are imminent. However, despite notable advances, several challenges remain. Here, we review PSC-CM pre-clinical studies, identifying key translational hurdles. We further discuss cell production and characterization strategies, identifying markers that may help generate cells which overcome these barriers.

Recent Findings
PSC-CMs can robustly repopulate infarcted myocardium with functional, force generating cardiomyocytes. However, current differentiation protocols produce immature and heterogenous cardiomyocytes, creating related issues such as arrhythmogenicity, immunogenicity and poor engraftment. Recent efforts have enhanced our understanding of cardiovascular developmental biology. This knowledge may help implement novel differentiation or gene editing strategies that could overcome these limitations.

Summary
PSC-CMs are an exciting therapeutic prospect. Despite substantial recent advances, limitations of the technology remain. However, with our continued and increasing biological understanding, these issues are addressable, with several worldwide clinical trials anticipated in the coming years.
The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease
Authors: Mannion Jenny M. , McLoughlin Rachel M. , Lalor Stephen J. 
Published: March 2022

AbstractThe respiratory tract is home to a diverse microbial community whose influence on local and systemic immune responses is only beginning to be appreciated. Increasing reports have linked changes in this microbiome to a range of pulmonary and extrapulmonary disorders, including asthma, chronic obstructive pulmonary disease and rheumatoid arthritis. Central to many of these findings is the role of IL-17-type immunity as an important driver of inflammation. Despite the crucial role played by IL-17-mediated immune responses in protection against infection, overt Th17 cell responses have been implicated in the pathogenesis of several chronic inflammatory diseases. However, our knowledge of the influence of bacteria that commonly colonise the respiratory tract on IL-17-driven inflammatory responses remains sparse. In this article, we review the current knowledge on the role of specific members of the airway microbiota in the modulation of IL-17-type immunity and discuss how this line of research may support the testing of susceptible individuals and targeting of inflammation at its earliest stages in the hope of preventing the development of chronic disease.
NMR assignment of non-modified tRNAIle from Escherichia coli
Authors: de Jesus Vanessa , Biedenbänder Thomas , Vögele Jennifer , Wöhnert Jens , Fürtig Boris 
Published: March 2022

AbstracttRNAs are L-shaped RNA molecules of ~ 80 nucleotides that are responsible for decoding the mRNA and for the incorporation of the correct amino acid into the growing peptidyl-chain at the ribosome. They occur in all kingdoms of life and both their functions, and their structure are highly conserved. The L-shaped tertiary structure is based on a cloverleaf-like secondary structure that consists of four base paired stems connected by three to four loops. The anticodon base triplet, which is complementary to the sequence of the mRNA, resides in the anticodon loop whereas the amino acid is attached to the sequence CCA at the 3′-terminus of the molecule. tRNAs exhibit very stable secondary and tertiary structures and contain up to 10% modified nucleotides. However, their structure and function can also be maintained in the absence of nucleotide modifications. Here, we present the assignments of nucleobase resonances of the non-modified 77 nt tRNAIle from the gram-negative bacterium Escherichia coli. We obtained assignments for all imino resonances visible in the spectra of the tRNA as well as for additional exchangeable and non-exchangeable protons and for heteronuclei of the nucleobases. Based on these assignments we could determine the chemical shift differences between modified and non-modified tRNAIle as a first step towards the analysis of the effect of nucleotide modifications on tRNA’s structure and dynamics.
Detection of Mechanically Separated Meat from Chicken in Sausages and Cold Meat by Targeted LC–MS/MS Analysis
Authors: Wilhelm Christian , Hofsommer Mikko , Wittke Stefan 
Published: March 2022

AbstractThe use of mechanically separated meat (MSM) from poultry in meat and sausage products is subject to declaration. Current methods such as microscopy or calcium analysis have proven to be insufficient to ensure the specific detection of MSM in meat and sausage products. When using MSM during production, intervertebral disc and cartilage specific proteins from chicken unavoidably end up in the sausages. Thus, a pseudo-MRM-LC–MS/MS-based assay was developed and validated, which uses intervertebral disc and cartilage specific peptides to detect MSM in meat and sausage products. All five marker peptides were assigned to collagen II alpha 1 which makes up a large part of the proteome of intervertebral discs and cartilage. In order to evaluate the validity of the methodology, a total of 23 positive controls (MSM content 5–90%) and a total of 19 negative controls were examined in a blinded study. After unblinding, 22 of 23 positive controls were correctly classified. Only one self-produced sample with 5% MSM was declared as a negative case (overall sensitivity 96%). In contrast, all negative controls were correctly classified as negative (specificity 100%). In summary, the LC–MS/MS assay allowed the specific detection of MSM in real samples with unknown composition down to 10% MSM in the meat content.
Graphical abstract