bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arm race among closely-related carbapenem-resistant Klebsiella pneumoniae clones
Authors: Liu Ying , Zhu Shichao , Wei Li , Feng Yu , Cai Lin , Dunn Steven , McNally Alan , Zong Zhiyong 
Published: August 2022

Abstract
Multiple carbapenem-resistant Klebsiella pneumoniae (CRKP) clones typically co-exist in hospital wards, but often certain clones will dominate. The factors driving this dominance are largely unclear. This study began from a genomic epidemiology analysis and followed by multiple approaches to identify the potential mechanisms driving the successful spread of a dominant clone. 638 patients in a 50-bed ICU were screened. 171 (26.8%) and 21 had CRKP from swabs and clinical specimens, respectively. Many (39.8% of those with ≥7-day ICU stay) acquired CRKP. After removing 18 unable to recover, 174 CRKP isolates were genome sequenced and belonged to six sequence types, with ST11 being the most prevalent (n = 154, 88.5%) and most (n = 169, 97.1%) carrying blaKPC-2. The 154 ST11 isolates belonged to 7 clones, with one (clone 1, KL64 capsular type) being dominant (n = 130, 84.4%). Clone 1 and the second-most common clone (clone 2, KL64, n = 15, 9.7%) emerged simultaneously, which was also detected by genome-based dating. Clone 1 exhibited decreased biofilm formation, shorter environment survival, and attenuated virulence. In murine gut, clone 1 outcompeted clone 2. Transcriptomic analysis showed significant upregulation of the ethanolamine operon in clone 1 when competing with clone 2. Clone 1 exhibited increased utilization of ethanolamine as a nitrogen source. This highlights that reduced virulence and enhanced ability to utilize ethanolamine may promote the success of nosocomial multidrug-resistant clones.
A DCS-related lncRNA signature predicts the prognosis and chemotherapeutic response of patients with gastric cancer
Authors: Zhang Yang , Li Leyan , Tu Yi , Feng Zongfeng , Li Zhengrong , Cao Yi , Li Yong 
Published: August 2022

Abstract
The combination of docetaxel, cisplatin, and S-1 (DCS) is a common chemotherapy regimen for patients with gastric cancer (GC). However, studies on long noncoding RNAs (lncRNAs) associated with the chemotherapeutic response to and prognosis after DCS remain lacking. The aim of the present study was to identify DCS mRNAs-lncRNAs associated with chemotherapy response and prognosis in GC patients. In the present study, we identified 548 lncRNAs associated with these 16 mRNAs in the TCGA and GSE31811 datasets. Eleven lncRNAs were used to construct a prognostic signature by least absolute shrinkage and selection operator (LASSO) regression. A model including the 11 lncRNAs (LINC02532, AC007277.1, AC005324.4, AL512506.1, AC068790.7, AC022509.2, AC113139.1, LINC00106, AC005165.1, MIR100HG, and UBE2R2-AS1) associated with the prognosis of GC was constructed. The signature was validated in the TCGA database, model comparison, and qRT-PCR experiments. The results showed that the risk signature was a more effective prognostic factor for GC patients. Furthermore, the results showed that this model can well predicting chemotherapy drug response and immune infiltration of GC patients. In addition, our experimental results indicated that lower expression levels of LINC00106 and UBE2R2-AS1 predicted worse drug resistance in AGS/DDP cells. The experimental results agreed with the predictions. Furthermore, knockdown of LINC00106 or UBE2R2-AS1 can significantly enhanced the proliferation and migration of GC AGS cells in vitro. In conclusion, a novel DCS therapy-related lncRNA signature may become a new strategy to predict chemotherapy response and prognosis in GC patients. LINC00106 and UBE2R2-AS1 may exhibit a tumor suppressive function in GC.
An ultra‐wideband low‐profile antenna for long‐term evolution/5G new radio sub‐6G applications
Authors: Cui Yuehui , Tu Zhenxing , Li RongLin 
Published: August 2022

AbstractAn ultra‐wideband dual‐polarized antenna with a low profile is proposed for base‐station applications. The dual‐polarized antenna consists of two crossed dipoles, a square patch, and a square meta‐surface. The ultra‐wideband operation is achieved by the coupling between the crossed dipoles and the square patch which creates multiple resonances. The square meta‐surface is introduced atop the antenna to improve the impedance matching. It is shown by simulation and experiment that the dual‐polarized antenna achieves an impedance bandwidth of 76.5% over 2.3 to 5.15 GHz for voltage standing wave ratio (VSWR)<1.5, covering the frequency bands for long term evolution LTE‐2300/2500 and 5G new radio (NR) sub‐6G n7/n38/n41/ n77/n78/n79 systems. The ultra‐wideband antenna features stable radiation patterns with a gain of 8.5 ± 0.5 dBi and a half‐power beam width (HPBW) of 65° ± 5°.
Curriculum Hannover – webbasierte vs. analoge
Durchführung der psychosomatischen Nachsorge und vs. Care as
usual
Authors: Dahmen Alina , Gao Lingling , Keller Franziska M. , Lehr Dirk , Becker Petra , Lippke Sonia 
Published: August 2022

Zusammenfassung
Ziel der Studie Zur Aufrechterhaltung des in der psychosomatischen
Rehabilitationsmaßnahme erzielten Effektes ist eine psychosomatische
Reha-Nachsorge bei den meisten Rehabilitanden indiziert. Aufgrund der geringen
wohnortnahen Versorgung mit Nachsorgetherapeuten ist die Nutzung digitaler
Angebote eine Möglichkeit, um einen ortsunabhängigen Zugang zu
ermöglichen. Ziel der Studie war die Evaluation der therapeutischen
Effekte einer webbasierten Nachsorge im Vergleich zu einer
Face-to-face-(F2F)-Therapie (beides auf konzeptioneller Basis des Curriculum
Hannover) in der Äquivalenzstudie und zu keiner standardisierten
Nachsorge (Care as usual, CAU) in der Überlegenheitsstudie.
Methodik 300 Rehabilitanden mit Indikation zur psychosomatischen Nachsorge
wurden bei Verfügbarkeit eines wohnortnahen Nachsorge-Angebotes der
Äquivalenzstudie zugewiesen und anschließend in F2F- oder
Online-Nachsorge randomisiert. Ohne wohnortnahes Angebot wurden die
Teilnehmenden der Überlegenheitsstudie zugewiesen und in Online- oder
CAU-Gruppe randomisiert. Die Outcomes (primär: psychische und
somatoforme Beschwerden, sekundär: Subskalen des HEALTH-49,
Erwerbstätigkeitsprognose, Arbeitsfähigkeit) wurden durch
Online-Fragebögen am Ende der Reha, 9 bzw. 12 und 15 bzw. 18 Monate nach
der Reha erhoben und durch multiple Imputation mit Intention-To-Treat-Analysen
ausgewertet. Für das primäre Outcome erfolgte zusätzlich
eine Sensitivitätsanalyse auf Basis des vollständigen
Datensatzes.
Ergebnisse Nach Ausschluss nonadhärenter Studienteilnehmer
erfolgte die Auswertung von n=142 Rehabilitanden in der
Äquivalenzstudie und n=111 in der Überlegenheitsstudie.
Es wurden in der Äquivalenzstudie keine signifikanten Unterschiede
(d=0,28 bzw. 0,10 bei ITT-Analysen; d=0,09 bzw. 0,03 bei
Auswertung nur des vollständigen Datensatzes) zwischen Online- und
F2F-Nachsorge in Bezug auf kurz- bzw. langfristige psychische und somatoforme
Beschwerden gefunden. In der Überlegenheitsstudie sanken langfristig
psychische und somatoforme Beschwerden in der Online-Gruppe, während sie
in der CAU-Gruppe zu T2 erst sanken (d=0,56) und zu T3 wieder stiegen
(d=0,72). Dieser Befund wurde durch die Analyse des
vollständigen Datensatzes validiert (d=0,12), während in
der Online-Gruppe die Beschwerden zu T3 anstiegen (d=0,10).
Schlussfolgerung Webbasierte psychosomatische Nachsorge scheint nach den
Ergebnissen der vorliegenden Studie einen längerfristigen Vorteil
für Rehabilitanden ohne Zugang zur bisherigen Nachsorge zu haben. Im
Vergleich zu der F2F-Durchführung kann sie als äquivalent
angesehen werden.
Femur 3D-DXA Assessment in Female Football Players, Swimmers, and
Sedentary Controls
Authors: Amani Amineh , Bellver Montse , del Rio Luis , Torrella Joan Ramon , Lizarraga Antonia , Humbert Ludovic , Drobnic Franchek 
Published: August 2022

AbstractCortical and trabecular volumetric bone mineral density (vBMD), cortical
thickness and surface BMD (sBMD, density-to-thickness ratio) were analyzed in
the proximal femur of elite female football players and artistic swimmers using
three-dimensional dual-energy X-ray absorptiometry (3D-DXA) software and
compared to sedentary controls. Football players had significantly higher
(p<0.05) vBMD (mg/cm3) in the trabecular
(263±44) and cortical femur (886±69) than artistic swimmers
(224±43 and 844±89) and sedentary controls (215±51 and
841±85). Football players had also higher (p<0.05) cortical
thickness (2.12±0.19 mm) and sBMD
(188±22 mg/cm2) compared to artistic
swimmers (1.85±0.15 and 156±21) and sedentary controls
(1.87±0.16 and 158±23). Artistic swimmers did not show
significant differences in any parameter analyzed for 3D-DXA when compared to
sedentary controls. The 3D-DXA modeling revealed statistical differences in
cortical thickness and vBMD between female athletes engaged in weight-bearing
(football) and non-weight bearing (swimming) sports and did not show differences
between the non-weight bearing sport and the sedentary controls. 3D-DXA modeling
could provide insight into bone remodeling in the sports field, allowing
evaluation of femoral trabecular and cortical strength from standard DXA
scans.
Meta-analysis of TCM in the Treatment of AIDS Diarrhea
Authors: Wu Shaotian , Xu Liran , Sang Feng , Li Liangping , Guo Yaya 
Published: August 2022

Abstract
Objective The aim of the study is to systematically evaluate the effect of Traditional Chinese medicine (TCM) in the treatment of AIDS diarrhea.
Methods The computer system was used to comprehensively search database of Wanfang (WF), VIP, and China National Knowledge Infrastructure (CNKI) for relevant literature on the application effect of Chinese medicine in the treatment of AIDS diarrhea. The retrieval time was set from January 1, 2010 to August 15, 2021. The documents that did not meet the inclusion criteria were eliminated, and the quality of the qualified literature was evaluated according to the improved Jadad scoring standard. The main outcome indicators were entered into the literature, and Review Manager 5.0 software was used for meta-analysis.
Results Eight eligible articles were included, a total of 536 cases of AIDS diarrhea patients were included. All eight eligible articles observed the clinical efficacy of TCM in the treatment of AIDS diarrhea, among which four observed the TCM syndrome changes in the treatment of AIDS diarrhea, and four observed adverse reactions of TCM in the treatment of AIDS diarrhea. All articles were extracted for valid data. After entering all the main observation index data, the results of meta-analysis showed that the effect of TCM in the treatment of AIDS diarrhea was better, the difference was statistically significant [MD = 2.92, 95% CI (1.81, 4.70), p <0.001]; TCM in the treatment of AIDS diarrhea was more conducive to improving the TCM syndrome scores of patients, the difference was statistically significant [MD = −2.55, 95% CI (−3.37, −1.73), p< 0.001]; the adverse effects of TCM in the treatment of AIDS diarrhea were mild, and the difference was statistically significant [MD = 1.70, 95% CI (0.48, 5.97), p = 0.41].
Conclusion The effect of TCM in the treatment of AIDS diarrhea patients is remarkable, which can effectively improve the TCM symptom scores of patients without increasing the incidence of adverse reactions.
Nonbilharzial Squamous Cell Bladder Cancer: An Indian Experience
Authors: Mittal Saket , Malik Kanuj , Raja Anand 
Published: August 2022

Background Squamous cell carcinoma represents the second most common histological type of bladder cancer. Nonbilharzial squamous cell carcinomas of bladder are rare histological variant with limited experience.
Objective We aimed to review our experience to determine various treatment patterns and survival outcomes for this malignancy.
Methods Data from patients treated at our center from 1995 to 2016 was collected from patient records and analyzed. Clinicopathological variables, treatment patterns, and follow-up data were extracted.
Results A total of 32 patients were included in the study with a median age of 55.5 years. Hematuria was the most common presentation. Overall, 16 patients underwent radical cystectomy, 8 underwent definitive radiotherapy (RT), 4 received palliative RT, and 4 patients defaulted for any treatment. Surgery conferred better survival rates as compared with RT (31.9 vs. 7.45 months). In the surgical group, only pathological TNM staging was a significant prognostic factor.
Conclusion In localized nonbilharzial squamous cell bladder cancer, radical cystectomy with bilateral pelvic node dissection appears to be treatment modality of choice. Larger series are needed to validate the role of other perioperative modalities.
Investigating patterns of change, stability, and interaction among scientific disciplines using embeddings
Authors: McGillivray Barbara , Jenset Gard B. , Salama Khalid , Schut Donna 
Published: August 2022

AbstractMulti-disciplinary and inter-disciplinary collaboration can be an appropriate response to tackling the increasingly complex problems faced by today’s society. Scientific disciplines are not rigidly defined entities and their profiles change over time. No previous study has investigated multiple disciplinarity (i.e. the complex interaction between disciplines, whether of a multidisciplinary or an interdisciplinary nature) at scale with quantitative methods, and the change in the profile of disciplines over time. This article explores a dataset of over 21 million articles published in 8400 academic journals between 1990 and 2019 and proposes a new scalable data-driven approach to multiple disciplinarity. This approach can be used to study the relationship between disciplines over time. By creating vector representations (embeddings) of disciplines and measuring the geometric closeness between the embeddings, the analysis shows that the similarity between disciplines has increased over time, but overall the size of their neighbourhood (the number of neighbouring disciplines) has decreased, pointing to disciplines being more similar to each other over time, while at the same time displaying increased specialisation. We interpret this as a pattern of global convergence combined with local specialisation. Our approach is also able to track the development of disciplines’ profiles over time, detecting those that changed the most in the time period considered, and to treat disciplines as compositional units, where relationships can be expressed as analogy equations of the form Discipline1 + Discipline2 ≈ Discipline3. These findings can help researchers, academic institutions and organizations to better understand and react to the dynamics of scientific research, and can support the education sector in designing curricula or in the recruitment of academics and researchers.
The effect of housing problems on older people’s subjective well-being in 21 European countries (Los efectos de los problemas de vivienda sobre el bienestar subjetivo de las personas mayores en 21 países europeos)
Authors: Bahnini Sara , Marques Sibila , Craveiro Daniela , Lima Maria-Luísa 
Published: August 2022

Housing has been acknowledged as a basic human need with an impact on health and well-being. Since older people tend to be more exposed to features in their home environment, it is important to identify specific vulnerabilities. This study used cross-sectional data of 40,185 respondents from the 2014 European Social Survey Round 7 to explore the relationship between housing problems, age group (≤ 70 years and > 70 years) and evaluative (life satisfaction) and hedonic (happiness) dimensions of subjective well-being (SWB) of 21 European countries. Housing problems were significantly associated with lower levels of happiness and life satisfaction (LS) in a multilevel model. The age group was found to be a moderator of that association. When exposed to housing problems, older people (> 70 years) presented lower levels of happiness than younger adults (≤ 70 years). These findings shed light on the differentiation of age groups and call for maintenance and improvement of housing conditions in later life, aiming to promote well-being.
A supramolecular injectable hydrogel based on β-cyclodextrin-grafted alginate and pluronic-amine loaded with kartogenin for chondrogenic differentiation of mesenchymal stem cells
Authors: Fallahi Hooman , Daemi Hamed , Bagheri Fatemeh , Baghaban Eslaminejad Mohamadreza 
Published: August 2022

Abstract
Owing to the similarity of hydrogels to cartilage extracellular matrix, they have been extensively utilized in the chondral lesions. Moreover, their tunable administration properties are desirable for reducing injuries in lesion sites. Generally, injectable hydrogels are mechanically weak, requiring some modifications for being used as a cell carrier in place of articular cartilage. In this study, a combination of β-cyclodextrin-grafted alginate (Alg-β-CD) and pluronic-amine with multiple physical crosslinking was used for the first time. Supramolecular interactions, including electrostatic forces, host-guest interaction, and hydrophobic interaction with increasing temperature maintain injectability of hydrogels while these interactions boost mechanical properties to the extent that shear modulus surpassed 40 kPa. Vacant β-CD cavities in conjunction with gel network were exploited for kartogenin (KGN) loading. All groups had gel time of less than one minute and gel temperature was 28 °C. No toxic effect of hydrogels on encapsulated cells was observed. While the optimum combination of polymers provided a sustainable release for KGN, it also extended the in vitro degradation time of hydrogels from six days to two weeks. KGN facilitated encapsulated mesenchymal stem cells differentiation towards chondrocytes. Taken together, the synthesized hydrogel proved to be a promising candidate for being utilized in cartilage regeneration.
Device for generating electrical energy based on thermal expansion of a solid material
Authors: Parsokhonov A , Kalandarov P , Olimov O , Akhmedov A 
Published: August 2022

Abstract
Popular renewable energy sources such as hydraulic, wind and solar energy, taken together, cannot completely replace natural sources. As a new alternative, this paper considers the thermal expansion energy of a solid material. A kinematic diagram and the principle of operation of a device that converts the thermal expansion energy of a steel rod into electricity are presented. Calculations show that new materials with given characteristics are needed to produce sufficient power.
Theoretical aspects of spraying working fluids in a curved method in precision farming systems
Authors: Irisov Kh D , Akhmedov D A , Aliboyev B A 
Published: August 2022

Abstract
In article is given the theoretical aspects of solving the existing technical and technological problems in improving the technical efficiency of working fluids, the device of a spray-caviator in a curved way, the device of a stream formed around a spiral deflection, the characteristic of a continuous flow, the process of leakage surrounded by a potential current of a primary drop. Analytical expressions were obtained as a result of mathematical analysis in the elementary study of the physical essence of this process. As a result of the circulatory – turbulization effect in theoretical research, it creates new opportunities for purposeful improvement of the caviator devices breaking down in the caviation method and wide introduction of high-volume spray technology in low volumes.
Resource-saving technologies as a factor of specialization of an agricultural enterprise in the Krasnoyarsk region
Authors: Rozhkova A V , Stepanova E V , Zdrestova-Zakharenkova S V , Rozhkov S E , Stepanov N S 
Published: August 2022

Abstract
The article considers the possibilities of using resource-saving technologies in agricultural enterprises of the region. The factors that contribute to the active development of introducring resource-saving technologies in the crop production of the Krasnoyarsk region are determined. The difficulties and potential for the grouwth of resource conservation have been identified, which make it possible to achieve an increase in efficiency, ecological safety and quality of agricultural products. The introduction of the proposed resource-saving technology is justified by calculations based on a multiple correlation and regression model. On the basis of the proposed model, the factorial characteristics of seed costs, energy availability, labor intensity that affect the effective feature such as the level of yield are identified. Resource-saving technologies when used in agricultural enterprises specializing in crop production can increase yields without changing the area of sowing and significantly reduce the cost of tillage and grain harvesting.
Harness softening roller for cotton cultivators
Authors: Abdualiev N Kh , Egamov N M 
Published: August 2022

Abstract
The article presents the technical means and technology of softening the areas formed after the germination of seeds in cotton farms. For this purpose, the designs of the existing softening devices are analyzed, and a softening device equipped with a softening coil with the most convenient structural solution is recommended. When using this device, the process of softening the dough reduces the labor consumption by 35% compared to the existing one, it allows to increase the productivity by 2-3 times.
Acceptable solutions for harvesting root crops in the soil climate of the Republic of Uzbekistan
Authors: Norchayev D R , Xaliqulov M A , Turkmenov X I , Shermuxamedov X P , Ibragimova G N 
Published: August 2022

Abstract
Currently, 165-175,000 acres [165-175,000 ha] of vegetables are planted by farmers in the districts. In 2021, vegetable crops were planted in the main area, 111,627 hectares of fields free of crops and grain, 65,149 hectares between gardens and vineyards, and a total of 343,160 hectares. In our country, root crops are cultivated in two seasons, that is, in spring and summer. If the root crop seeds sown in the spring are harvested in the middle of summer, the one in summer is harvested in late October and early November. These two collection seasons will vary from one another according to the soil-climatic conditions. This in turn complicates the harvesting of root crops. An improved carrot digging is designed to harvest the autumn harvest, and applying it for the summer harvest is not recommended. Because of the fact that during the summer season, we are more likely to damage the crop because the soil conditions are hot and dry. Improved carrot digging reduces manual labor and improves work productivity. It is recommended to use a universal root crop harvester to harvest the crop in the summer season since the heat and dry conditions of the soil during the summer season can cause an increase in the level of root crop damage in driving the crop to the surface of the earth. Another reason for the increase in damage is that solid soil cuts should not be crushed because this humidity is low.