bluuebunny/crossref_metadata_2025_split huggingface dataset:
Political Rights Regulation by Deferral: Obstacles to External Voting in Uruguay
Authors: Margheritis Ana 
Published: February 2022

ABSTRACTWhy hasn’t Uruguay enfranchised emigrants yet? This study examines an underresearched case of nonenfranchisement and engages with debates on external voting, diaspora politics, and citizenship beyond borders. Building on qualitative and participatory methods, the analysis unveils the obstacles to franchise reform despite significant progress from 2004 to 2019. Although external voting was not enacted legally, emigrants’ voting rights were debated, formally acknowledged, and encouraged. It is not the lack of norm entrepreneurs but the cumulative effect of indecisive actions that perpetuates a counterproductive dynamic and de facto uneven access to this right. An unresolved debate simultaneously advances conversations but precludes compromises, turning resolution deferral into an implicit form of regulating emigrants’ political inclusion or exclusion. Presenting original evidence, this study expands existing accounts, highlights the interaction between institutional and social drivers of change, and invites further research on the role of policy diffusion, domestic politics, and timing.
Caldwell's Dravidians: Knowledge production and the representational strategies of missionary scholars in colonial South India
Authors: Solomon John 
Published: February 2022

AbstractThis article examines British Protestant missionary scholars' representations of Tamil culture and history, analysing how this form of knowledge evolved in relation to missionary concerns and the intellectual trends of nineteenth-century India. I focus on the work of Robert Caldwell, whose scholarship had a profound influence on the identity discourses of twentieth-century Tamil nationalism. I situate Caldwell's work in ethnography and philology within the broader field of colonial knowledge produced about Tamils in nineteenth-century India and within a broader study of British missionary concerns in South India. I examine two of Caldwell's publications to argue that his later work, far from being driven by mere scholarly interests, was also shaped by his concerns as a missionary, and that his evolving scholarship mirrored the development of anti-Brahmanism in British Protestant missionary circles of the time. Missionary anti-Brahmanism arose as a response to the caste system, which missionary groups came to regard as the biggest obstacle to Christian conversions. Departing from some of his earlier ideas, Caldwell strategically positioned his later work to challenge Brahman influence, which he saw as being intrinsically tied to the strength of caste sentiment in Indian society. Caldwell's construction of a discursive framework for understanding Tamil linguistic identity was informed by public reactions to his first publication and his subsequent understanding of the dynamic relationship between European scholarship and Indian social relations. More broadly, this article demonstrates the close relationships between Protestant Christian missionary activity, Indian social politics, and the field of knowledge production in colonial South India.
SIMU/Triple star sensors integrated navigation method of HALE UAV based on atmospheric refraction correction
Authors: Gao Ziqian , Wang Haiyong , Wang Weihong , Xu Yuan 
Published: February 2022

AbstractTo achieve autonomous all-day flight by high-altitude long-endurance unmanned aerial vehicle (HALE UAV), a new navigation method with deep integration of strapdown inertial measurement unit (SIMU) and triple star sensors based on atmospheric refraction correction is proposed. By analysing the atmospheric refraction model, the stellar azimuth coordinate system is introduced and the coupling relationship between attitude and position is established. Based on the geometric relationship whereby all the stellar azimuth planes intersect on the common zenith direction, the sole celestial navigation system (CNS) method by stellar refraction with triple narrow fields of view (FOVs) is studied and a loss function is built to evaluate the navigation accuracy. Finally, the new SIMU/triple star sensors deep integrated navigation method with refraction correction upgraded from the traditional inertial navigation system (INS)/CNS integrated method can be established. The results of simulations show that the proposed method can effectively restrain navigation error of a HALE UAV in 24 h steady-state cruising in the stratosphere.
Trust in the scientific research community predicts intent to comply with COVID-19 prevention measures: An analysis of a large-scale international survey dataset
Authors: Han Hyemin 
Published: February 2022

Abstract
In the present study, I explored the relationship between people's trust in different agents related to the prevention of the spread of coronavirus disease 2019 (COVID-19) and their compliance with pharmaceutical and non-pharmaceutical preventive measures. The COVIDiSTRESSII Global Survey dataset, which was collected from international samples, was analysed to examine the aforementioned relationship across different countries. For data-driven exploration, network analysis and Bayesian generalised linear model (GLM) analysis were performed. The result from network analysis demonstrated that trust in the scientific research community was most central in the network of trust and compliance. In addition, the outcome from Bayesian GLM analysis indicated that the same factor, trust in the scientific research community, was most fundamental in predicting participants' intent to comply with both pharmaceutical and non-pharmaceutical preventive measures. I briefly discussed the implications of the findings, the importance of trust in the scientific research community in explaining people's compliance with a measure to prevent the spread of COVID-19.
Normative Resilience
Authors: Andersson Henrik , Werkmäster Jakob 
Published: February 2022

AbstractThis article discusses the phenomenon of normative resilience, with a focus on evaluative resilience. An object can become more or less valuable. In addition to this change in an object's value, the object's value can become more or less resilient. If it is less resilient, it cannot withstand as much evaluative change without its degree of value changing, as compared to an object with more resilient value. The article consists of three parts. First, examples of resilience are presented to give the reader an intuitive understanding of the phenomenon, Second, the Fitting Attitudes Analysis of value is invoked to provide a formal account of evaluative resilience. Third, the theoretical and practical advantages of acknowledging the existence of evaluative resilience are brought to light.
Emerging Trends: SOTA-Chasing
Authors: Church Kenneth Ward , Kordoni Valia 
Published: February 2022

AbstractMany papers are chasing state-of-the-art (SOTA) numbers, and more will do so in the future. SOTA-chasing comes with many costs. SOTA-chasing squeezes out more promising opportunities such as coopetition and interdisciplinary collaboration. In addition, there is a risk that too much SOTA-chasing could lead to claims of superhuman performance, unrealistic expectations, and the next AI winter. Two root causes for SOTA-chasing will be discussed: (1) lack of leadership and (2) iffy reviewing processes. SOTA-chasing may be similar to the replication crisis in the scientific literature. The replication crisis is yet another example, like evaluation, of over-confidence in accepted practices and the scientific method, even when such practices lead to absurd consequences.
Basal Melting, Roughness and Structural Integrity of Ice Shelves
Authors: Larter Robert D. 
Published: February 2022

AbstractIce shelves restrict outflow from many of the largest glaciers in Antarctica, thus limiting the Antarctic contribution to sea‐level rise. However, past ice‐shelf collapse events show they are highly vulnerable to surface and basal melting. Collapse of ice shelves in front of glaciers flowing on retrograde slopes could initiate runaway retreat processes. Difficulty in projecting how quickly these could play out makes dynamic ice loss from Antarctica the largest uncertainty in predicting future sea‐level rise. Basal melting can impact structural integrity of ice shelves in several ways. Results from analyses of variations in ice‐shelf roughness by Watkins et al. (2021; https://doi.org/10.1029/2021GL094743) raise the tantalizing prospect that this may provide a simple quantitative measure of how the structural integrity of an ice shelf has been impacted by basal melting. Applying the method to additional ice shelves would be useful to examine how other factors may contribute to roughness.
Coastal Hazards of Tropical‐Like Cyclones Over the Mediterranean Sea
Authors: Toomey Tim , Amores Angel , Marcos Marta , Orfila Alejandro , Romero Romualdo 
Published: February 2022

AbstractMedicanes, for Mediterranean hurricanes, are mesoscale cyclones with morphological and physical characteristics similar to tropical cyclones. Although less intense, smaller, and rarer than their Atlantic counterparts, medicanes are very hazardous events threatening islands and continental coasts within the Mediterranean Sea. The latest strong episode, Medicane Ianos (September 2020), resulted in severe damages in Greece and several casualties. This work investigates the oceanic response to these extreme events along the Mediterranean coasts under present‐day and future (late 21st century) climate conditions. To this end, a coupled hydrodynamic‐wave model is used to simulate both storm surges and wind‐waves generation and propagation in the Mediterranean Sea at high resolution (∼2 km) along the coastlines. A data set of thousands of medicanes synthetically generated from 20 global climate models and two atmospheric reanalyses is used to derive the atmospheric forcing fields. Regional coastal hazards assessment is performed for the present and future climates. For the first period, highest medicane‐induced waves are found in the central and the southwest part of the western Mediterranean, while greatest storm surges are found in the Adriatic Sea and regions characterized by wide and gently sloping continental shelves. Results obtained for future changes show amplitudes generally smaller than the associated uncertainty due to limited agreement among models (especially for coastal elevation). Though, model consensus is reached (60–75%) and relative intensity change is significant (10–20%) at some locations (e.g., 1 m increase of medicane‐induced significant wave height on average for south coasts of Sicilia).
MST1 deletion protects β-cells in a mouse model of diabetes
Authors: Ardestani Amin , Maedler Kathrin 
Published: February 2022

AbstractThe pro-apoptotic kinase Mammalian Sterile 20-like kinase 1 (MST1), an integral component of the Hippo pathway, is a key regulator of organ size, stress response, and tissue homeostasis; its aberrant hyperactivation is linked to multiple pathological disorders including diabetes. Here we show that MST1 deletion in mice resulted in improved glucose tolerance and insulin secretion, and restored pancreatic β-cell mass as a result of improved β-cell survival and proliferation in the combined high fat/high sucrose and streptozotocin (HFS/STZ) model of β-cell destruction and diabetes. Importantly, the glucose-lowering effects in the MST1-knockout (KO) mice could be accounted to the enhanced β-cell mass and improved insulin secretion without changes in insulin sensitivity. Metabolic and morphological data suggest that normalization of blood glucose and insulin secretion, islet architecture, and β-cell mass by MST1 deletion in response to diabetes-induced injury occurs as a result of improved β-cell survival and proliferation establishing MST1 as potent regulator of physiological β-cell turnover.
A serum proteomic study of two case-control cohorts identifies novel biomarkers for bipolar disorder
Authors: Göteson Andreas , Isgren Anniella , Sparding Timea , Holmén-Larsson Jessica , Jakobsson Joel , Pålsson Erik , Landén Mikael 
Published: February 2022

AbstractWe set out to identify novel protein associations with potential as clinically viable biomarkers for bipolar disorder. To this end, we used proximity extension assay to analyze 201 unique proteins in blood serum from two independent cohorts comprising patients with bipolar disorder and healthy controls (totaln = 493). We identified 32 proteins significantly associated with bipolar disorder in both case-control cohorts after adjusting for relevant covariates. Twenty-two findings are novel to bipolar disorder, but 10 proteins have previously been associated with bipolar disorder: chitinase-3-like protein 1, C-C motif chemokine 3 (CCL3), CCL4, CCL20, CCL25, interleukin 10, growth/differentiation factor-15, matrilysin (MMP-7), pro-adrenomedullin, and TNF-R1. Next, we estimated the variance in serum protein concentrations explained by psychiatric drugs and found that some case-control associations may have been driven by psychiatric drugs. The highest variance explained was observed between lithium use and MMP-7, and in post-hoc analyses and found that the serum concentration of MMP-7 was positively associated with serum lithium concentration, duration of lithium therapy, and inversely associated with estimated glomerular filtration rate in an interaction with lithium. This is noteworthy given that MMP-7 has been suggested as a mediator of renal tubulointerstitial fibrosis, which is characteristic of lithium-induced nephropathy. Finally, we used machine learning to evaluate the classification performance of the studied biomarkers but the average performance in unseen data was fair to moderate (area under the receiver operating curve = 0.72). Taken together, our serum biomarker findings provide novel insight to the etiopathology of bipolar disorder, and we present a suggestive biomarker for lithium-induced nephropathy.
ATAD3B and SKIL polymorphisms associated with antipsychotic-induced QTc interval change in patients with schizophrenia: a genome-wide association study
Authors: Lu Zhe , Zhang Yuyanan , Yan Hao , Su Yi , Guo Liangkun , Liao Yundan , Lu Tianlan , Yu Hao , Wang Lifang , Li Jun , Li Wenqiang , Yang Yongfeng , Xiao Xiao , Lv Luxian , Tan Yunlong , Zhang Dai , Yue Weihua 
Published: February 2022

AbstractQTc interval prolongation is one of the most common antipsychotic-induced side effects which could lead to ventricular tachycardia or Torsade de Pointes, even cardiac arrest. There is very limited understanding on the genetic factors that associated with antipsychotic-induced QTc interval change. We conducted a genome-wide association study (GWAS) of antipsychotic-induced QTc interval change among patients with schizophrenia. A total of 2040 patients with schizophrenia were randomly assigned to six groups (olanzapine, risperidone, quetiapine, aripiprazole, ziprasidone, and first-generation antipsychotics; first-generation antipsychotics including haloperidol or perphenazine were also assigned randomly) and received 6-week antipsychotic treatment. We identified two novel loci (rs200050752 in ATAD3B and rs186507741 in SKIL) that were associated with antipsychotic-induced QTc interval change at a genome-wide significance level. The combination of polygenic risk score (PRS), based the GWAS of myocardial infarction from BioBank Japan project, and clinical data (sex, heart rate and QTc interval at baseline) could be applied to predict whether patients with schizophrenia have QTc interval prolongation (10 ms was applied as threshold, P < 0.001, area under the curve [AUC] was 0.797), especially for the first episode patients (P < 0.001, AUC was 0.872). We identified two loci located within genes related to mitochondrial function and cell growth and differentiation, which were both associated with schizophrenia and heart function. The combination of PRS and clinical data could predict whether patients with schizophrenia have the side effect of QTc interval prolongation, which could fundamentally guide the choice of antipsychotic in patients with schizophrenia, especially for the first-episode patients.
Predicting the efficiency of oxygen-evolving electrolysis on the Moon and Mars
Authors: Lomax Bethany A. , Just Gunter H. , McHugh Patrick J. , Broadley Paul K. , Hutchings Gregory C. , Burke Paul A. , Roy Matthew J. , Smith Katharine L. , Symes Mark D. 
Published: February 2022

AbstractEstablishing a permanent human presence on the Moon or Mars requires a secure supply of oxygen for life support and refueling. The electrolysis of water has attracted significant attention in this regard as water-ice may exist on both the Moon and Mars. However, to date there has been no study examining how the lower gravitational fields on the Moon and Mars might affect gas-evolving electrolysis when compared to terrestrial conditions. Herein we provide experimental data on the effects of gravitational fields on water electrolysis from 0.166 g (lunar gravity) to 8 g (eight times the Earth’s gravity) and show that electrolytic oxygen production is reduced by around 11% under lunar gravity with our system compared to operation at 1 g. Moreover, our results indicate that electrolytic data collected using less resource-intensive ground-based experiments at elevated gravity (>1 g) may be extrapolated to gravitational levels below 1 g.
Double face of cytochrome c in cancers by Raman imaging
Authors: Abramczyk H. , Brozek-Pluska B. , Kopeć M. 
Published: February 2022

AbstractCytochrome c (Cyt c) is a key protein that is needed to maintain life (respiration) and cell death (apoptosis). The dual-function of Cyt c comes from its capability to act as mitochondrial redox carrier that transfers electrons between the membrane-embedded complexes III and IV and to serve as a cytoplasmic apoptosis-triggering agent, activating the caspase cascade. However, the precise roles of Cyt c in mitochondria, cytoplasm and extracellular matrix under normal and pathological conditions are not completely understood. To date, no pathway of Cyt c release that results in caspase activation has been compellingly demonstrated in any invertebrate. The significance of mitochondrial dysfunctionality has not been studied in ductal carcinoma to the best of our knowledge. We used Raman spectroscopy and imaging to monitor changes in the redox state of the mitochondrial cytochromes in ex vivo surgically resected specimens of human breast tissues, and in vitro human breast cells of normal cells (MCF 10A), slightly malignant cells (MCF7) and highly aggressive cells (MDA-MB-231). We showed that Raman imaging provides insight into the biology of human breast ductal cancer. Here we show that proper concentration of monounsaturated fatty acids, saturated fatty acids, cardiolipin and Cyt c is critical in the correct breast ductal functioning and constitutes an important parameter to assess breast epithelial cells integrity and homeostasis. We look inside human breast ducts by Raman imaging answering fundamental questions about location and distribution of various biochemical components inside the lumen, epithelial cells of the duct and the extracellular matrix around the cancer duct during cancer development in situ. Our results show that human breast cancers demonstrate a redox imbalance compared to normal tissue. The reduced cytochrome c is upregulated in all stages of cancers development. The results of the paper shed light on a largely non-investigated issues regarding cytochromes and mitochondrial function in electron transfer chain. We found in histopathologically controlled breast cancer duct that Cyt c, cardiolipin, and palmitic acid are the main components inside the lumen of cancerous duct in situ. The presented results show direct evidence that Cyt c is released to the lumen from the epithelial cells in cancerous duct. In contrast the lumen in normal duct is empty and free of Cyt c. Our results demonstrate how Cyt c is likely to function in cancer development. We anticipate our results to be a starting point for more sophisticated in vitro and in vivo animal models. For example, the correlation between concentration of Cyt c and cancer grade could be tested in various types of cancer. Furthermore, Cyt c is a target of anti-cancer drug development and a well-defined and quantitative Raman based assay for oxidative phosphorylation and apoptosis will be relevant for such developments.
Difference in spectral power density of sleep electroencephalography between individuals without insomnia and frequent hypnotic users with insomnia complaints
Authors: Kang Jae Myeong , Cho Seo-Eun , Moon Jong Youn , Kim Soo In , Kim Jong Won , Kang Seung-Gul 
Published: February 2022

AbstractPrevious spectral analysis studies on insomnia have shown inconsistent results due to their heterogeneity and small sample sizes. We compared the difference of electroencephalogram (EEG) spectral power during sleep among participants without insomnia, insomniacs with no hypnotic use, hypnotic users with no insomnia complaints, and hypnotic users with insomnia complaints using the Sleep Heart Health Study data, which is large sample size and has good quality control. The fast Fourier transformation was used to calculate the EEG power spectrum for total sleep duration within contiguous 30-s epochs of sleep. For 1985 participants, EEG spectral power was compared among the groups while adjusting for potential confounding factors that could affect sleep EEG. The power spectra during total sleep differed significantly among the groups in all frequency bands (pcorr < 0.001). We found that quantitative EEG spectral power in the beta and sigma bands of total sleep differed (pcorr < 0.001) between participants without insomnia and hypnotic users with insomnia complaints after controlling for potential confounders. The higher beta and sigma power were found in the hypnotic users with insomnia complaints than in the non-insomnia participants. This study suggests differences in the microstructures of polysomnography-derived sleep EEG between the two groups.
Modeling axonal regeneration by changing cytoskeletal dynamics in stem cell-derived motor nerve organoids
Authors: Seo Woo Min , Yoon Jiyoung , Lee Ju-Hyun , Lee Yunjeong , Lee Hojae , Geum Dongho , Sun Woong , Song Mi-Ryoung 
Published: February 2022

AbstractOxidative stress triggers axon degeneration and cell death, leading to the development of neurodegenerative diseases. Spinal motor nerves project very long axons, increasing the burden on axonal transport and metabolism. As such, spinal motor nerves are expected to be susceptible to oxidative stress, but model systems for visualizing and investigating acutely degenerating motor axons are limited. In this study, we establish motor nerve organoids from human pluripotent stem cells (hPSCs) with properties similar to those of neuromesodermal progenitors (NMPs), a population of progenitor cells that comprise the caudal spinal cord. Three-dimensional differentiation of organoids efficiently gave rise to mature motor neurons within 18 days. Adherent organoids showed robust axon fascicles and active growth cones under normal conditions. In addition, more homogenous and efficient generation of motor neurons were achieved when organoids were dissociated into individual cells. Hydrogen peroxide-induced oxidative stress resulted in a broad range of signs of axon degeneration including the disappearance of growth cones and neurites, axon retraction, axon fragmentation and bleb formation, and apoptotic cell death, whose severity can be reliably quantifiable in our culture system. Remarkably, cytoskeletal drugs modulating actin or microtubule turnover differentially facilitated axon dynamics and increased axon regenerative potential. Taken together, our motor nerve organoid model could be potentially useful for drug screens evaluating the rearrangement of cytoskeletons in regenerating motor axons.