bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of a COVID-19 outbreak on the Charles de Gaulle aircraft carrier, March to April 2020: a retrospective cohort study
Authors: de Laval Franck , Chaudet Hervé , Gorgé Olivier , Marchi Joffrey , Lacrosse Constance , Dia Aissata , Marbac Vanessa , Mmadi Mrenda Bakridine , Texier Gaëtan , Letois Flavie , Chapus Charles , Sarilar Véronique , Tournier Jean-Nicolas , Levasseur Anthony , Cobola Jacques , Nolent Flora , Dutasta Fabien , Janvier Frédéric ,   PA-CDG COVID-19 investigation group, Meynard Jean-Baptiste , Pommier de Santi Vincent 
Published: May 2022

Background
SARS-CoV-2 emergence was a threat for armed forces. A COVID-19 outbreak occurred on the French aircraft carrier Charles de Gaulle from mid-March to mid-April 2020.

Aim
To understand how the virus was introduced, circulated then stopped circulation, risk factors for infection and severity, and effectiveness of preventive measures.

Methods
We considered the entire crew as a cohort and collected personal, clinical, biological, and epidemiological data. We performed viral genome sequencing and searched for SARS-CoV-2 in the environment.

Results
The attack rate was 65% (1,148/1,767); 1,568 (89%) were included. The male:female ratio was 6.9, and median age was 29 years (IQR: 24–36). We examined four clinical profiles: asymptomatic (13.0%), non-specific symptomatic (8.1%), specific symptomatic (76.3%), and severe (i.e. requiring oxygen therapy, 2.6%). Active smoking was not associated with severe COVID-19; age and obesity were risk factors. The instantaneous reproduction rate (Rt) and viral sequencing suggested several introductions of the virus with 4 of 5 introduced strains from within France, with an acceleration of Rt when lifting preventive measures. Physical distancing prevented infection (adjusted OR: 0.55; 95% CI: 0.40–0.76). Transmission may have stopped when the proportion of infected personnel was large enough to prevent circulation (65%; 95% CI: 62–68).

Conclusion
Non-specific clinical pictures of COVID-19 delayed detection of the outbreak. The lack of an isolation ward made it difficult to manage transmission; the outbreak spread until a protective threshold was reached. Physical distancing was effective when applied. Early surveillance with adapted prevention measures should prevent such an outbreak.
Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021
Authors: Kissling Esther , Hooiveld Mariëtte , Martínez-Baz Iván , Mazagatos Clara , William Naoma , Vilcu Ana-Maria , Kooijman Marjolein N , Ilić Maja , Domegan Lisa , Machado Ausenda , de Lusignan Simon , Lazar Mihaela , Meijer Adam , Brytting Mia , Casado Itziar , Larrauri Amparo , Murray Josephine-L K , Behillil Sylvie , de Gier Brechje , Mlinarić Ivan , O’Donnell Joan , Rodrigues Ana Paula , Tsang Ruby , Timnea Olivia , de Lange Marit , Riess Maximilian , Castilla Jesús , Pozo Francisco , Hamilton Mark , Falchi Alessandra , Knol Mirjam J , Kurečić Filipović Sanja , Dunford Linda , Guiomar Raquel , Cogdale Jade , Cherciu Carmen , Jansen Tessa , Enkirch Theresa , Basile Luca , Connell Jeff , Gomez Verónica , Sandonis Martín Virginia , Bacci Sabrina , Rose Angela MC , Pastore Celentano Lucia , Valenciano Marta ,   I-MOVE-COVID-19 and ECDC primary care study teams
Published: May 2022

Introduction
In July and August 2021, the SARS-CoV-2 Delta variant dominated in Europe.

Aim
Using a multicentre test-negative study, we measured COVID-19 vaccine effectiveness (VE) against symptomatic infection.

Methods
Individuals with COVID-19 or acute respiratory symptoms at primary care/community level in 10 European countries were tested for SARS-CoV-2. We measured complete primary course overall VE by vaccine brand and by time since vaccination.

Results
Overall VE was 74% (95% CI: 69–79), 76% (95% CI: 71–80), 63% (95% CI: 48–75) and 63% (95% CI: 16–83) among those aged 30–44, 45–59, 60–74 and ≥ 75 years, respectively. VE among those aged 30–59 years was 78% (95% CI: 75–81), 66% (95% CI: 58–73), 91% (95% CI: 87–94) and 52% (95% CI: 40–61), for Comirnaty, Vaxzevria, Spikevax and COVID-19 Vaccine Janssen, respectively. VE among people 60 years and older was 67% (95% CI: 52–77), 65% (95% CI: 48–76) and 83% (95% CI: 64–92) for Comirnaty, Vaxzevria and Spikevax, respectively. Comirnaty VE among those aged 30–59 years was 87% (95% CI: 83–89) at 14–29 days and 65% (95% CI: 56–71%) at ≥ 90 days between vaccination and onset of symptoms.

Conclusions
VE against symptomatic infection with the SARS-CoV-2 Delta variant varied among brands, ranging from 52% to 91%. While some waning of the vaccine effect may be present (sample size limited this analysis to only Comirnaty), protection was 65% at 90 days or more between vaccination and onset.
Sustainable community forest management in West Kalimantan: A case study of the Dayak Katab Kebahan community
Authors: Tien Aminatun  , Kuswarsantyo  , Suhartini  , Rangpan Vichit , Prasojo Zaenuddin Hudi , Andreyani Anggun 
Published: May 2022

West Kalimantan has great potential of forests and indigenous people. Therefore, it is crucial to study on forest management by indigenous people. The study is aimed at analyzing the forest management carried out by the Dayak Katab Kebahan community; and the condition of the forest ecosystem. The research area is in Melawi Regency, West Kalimantan. Observations and in-depth interviews were conducted to explore the customs in managing forests. A vegetation survey using purposive sampling was performed. The fauna study was conducted by the exploration method. Vegetation data analysis was carried out by calculating the importance value and diversity indices. One-way ANOVA analysis was done to determine the presence of forest ecosystem differences between two forests. The findings showed forest managed by the Dayak Katab Kebahan community has a core zone which is a zone that should not be disturbed, and a cultivation zone which can be utilized and can be intercropped with plantation crops; and the forest ecosystem managed by the Dayak Katab Kebahan community has a higher fauna richness, vegetation diversity index and the importance value index of each species. It is suggested that the government be involved in supporting the customary law of local communities in forest conservation.
Pengaruh Kegiatan Kajian Himpunan Putusan Tarjih Muhammadiyah Terhadap Pengamalan Ibadah Santri
Authors: Hikmah Jasy Febrianita Nurlaelatul , Darodjat Darodjat 
Published: May 2022

Penelitian ini bertujuan untuk mengetahui ada tidaknya pengaruh pelaksanaan kegiatan kajian Himpunan Putusan Tarjih Muhammadiyah terhadap pengamalan ibadah santri di Pondok Pesantren Muhammadiyah Ahmad Dahlan Kabupaten Tegal. Penelitian ini menggunakan jenis penelitian kuantitatif korelasional. Dalam penelitian ini menggunakan Teknik pengumpulan data dengan wawancara, angket, observasi, dan dokumentasi. Analisis data yang digunakan dalam penelitian ini menggunakan analisis data korelasi pearson product moment. Hasil analisis data dalam penelitian ini menunjukan bahwa tidak ada pengaruh antara kegiatan kajian Himpunan Putusan Tarjih Muhammadiyah dengan pengamalan ibadah santri di Pondok Pesantren Muhammadiyah Ahmad Dahlan Kabupaten Tegal. Hal tersebut dibuktikan dengan hasil perhitungan korelasi pearson product moment sebesar 0,185 sedangkan nilai r hitung pada signifikansi 5% diperoleh sebesar 0,433 dan pada taraf signifikansi 1% diperoleh sebesar 0,549 sehingga r hitung < r tabel atau 0,185 < 0,433 dengan demikian maka ditolak dan diterima, berarti tidak ada pengaruh kegiatan kajian Himpunan Putusan Tarjih Muhammadiyah terhadap pengamalan ibadah santri di Pondok Pesantren Muhammadiyah Ahmad Dahlan Kabupaten Tegal.
Analisa UI/UX Terhadap Perancangan Website Laundry dengan Metode Human Centered Design dan User Experience Questionnaire
Authors: Salsabilah Salsabilah , Wahyuddin Moh. Iwan , Sari Ratih Titi Komala 
Published: May 2022

The development of information technology today has developed very rapidly where in its development can help people from all walks of life in doing anything, one of which is in the laundry service business sector. My laundry is one of the businesses that offer Laundry services that provide kiloan washingservices. In My laundry In doing data collection or recording my laundry data still does manually. In solving the problems that occur in my laundry system the solution is to apply an information technology system that uses a website. In a design of user interface and user experience can be used as basic things in the creation of a website. In conducting analysis and design of user interface and user experience using the Human Centered Design (HCD) approach and user experience questionnaire (UEQ) method is expected to provide conveniencefor users of the website
PENGENALAN KARAKTER BRAILLE MEMANFAATKAN CONVOLUTIONAL NEURAL NETWORK
Authors: Andriansyah Marindo , Junaedi Hartarto 
Published: May 2022

ABSTRACTBraille is a character designed for the blind. Braille letters consist of six raised dots arranged in three rows and two columns. Braille is read by touch, so finger sensitivity is very important. Braille combinations need to be memorized, making them very difficult to learn. This study discusses the introduction of braille characters using the Convolutional Neural Network (CNN) method. CNN will process 3 data sets, 60, 100, and 150 data with each data using 5, 10, 25, and 50 epochs. The highest accuracy value in the training process is 99.87% with a loss value of 0.232. In the recognition process, the highest accuracy is 99.62% with a recognition error of 1 image out of 260 images.
Keywords: Braille, CNN, Character, Recognition.

ABSTRAKHuruf braille merupakan karakter yang dirancang untuk orang buta. Huruf braille terdiri dari enam titik timbul yang tersusun dalam tiga baris dan dua kolom. Huruf braille dibaca dengan menggunakan sentuhan, oleh sebab itu sensifitas jari sangat penting. Kombinasi huruf braille perlu dihafalkan, sehingga sangat sulit untuk dipelajari. Penelitian ini membahas pengenalan karakter braille dengan menggunakan metode Convolutional Neural Network (CNN). CNN akan memproses 3 kelompok data, 60, 100, dan 150 data dengan masing-masing data menggunakan 5, 10, 25, dan 50 epoch. Nilai akurasi tertinggi pada proses traning sebesar 99.87% dengan nilai loss sebesar 0.232. Dalam proses pengenalan akurasi tertinggi sebesar 99.62% dengan kesalahan pengenalan 1 gambar dari 260 gambar.
Kata Kunci: Braille, CNN, Karakter, Pengenalan.
The Kandungan Fitokimia dan Aktivitas Antioksidan Krim Fraksi Etanol Kulit Buah Jeruk Manis (Citrus sinensis (L.) Osbeck)
Authors: SARI WAHYUNITA YULIA , Yuliastuti Definingsih , Ulfa Maria 
Published: May 2022

Buah jeruk manis umumnya dimanfaatkan pada bagian daging buah, sedangkan kulitnya hanya menjadi limbah. Limbah kulit buah jeruk manis banyak dijumpai di masyarakat memiliki kandungan senyawa antioksidan. Limbah kulit buah jeruk manis dapat diolah menjadi sediaan krim yang dapat dimanfaatkan oleh masyarakat.
Krim dari limbah kulit buah jeruk manis dibuat menggunakan metode ekstraksi maserasi dan fraksinasi cair-cair. Metode ekstraksi maserasi menggunakan pelarut etanol 70%, sedangkan metode fraksinasi menggunakan pelarut n-Heksana, etil asetat dan etanol 70%. Krim fraksi etanol 70% kulit buah jeruk manis dibuat dalam beberapa formula FI (3%), FII (6%) dan FIII (9%). Skrining kandungan fitokimia dari kulit buah jeruk manis dilakukan menggunakan pereaksi kimia.
Kulit buah jeruk manis memiliki kandungan senyawa vitamin C, flavonoid dan minyak atsiri. Sediaan krim fraksi etanol 70% kulit buah jeruk (FI, FII, FIII) menunjukkan bahwa krim memiliki warna, tekstur dan sifat fisik yang baik.
Studi Potensi Interaksi Antibiotik Dengan Obat Lain Pada Peresepan Pasien Pneumonia Di Intensive Care Unit
Authors: Farida Yeni 
Published: May 2022

Pneumonia adalah salah satu infeksi saluran nafas bawah akut yang banyak menyebabkan morbiditas dan mortalitas. Antibiotik merupakan terapi utama yang digunakan pada kasus infeksi bakteri. Penggunaan bersamaan dengan obat lain memungkinkan terjadinya interaksi yang merugikan. Penelitian ini bertujuan untuk mengetahui antibiotik yang berpotensi interaksi obat dan pengaruhnya terhadap kondisi pasien berdasarkan data klinis maupun laboratorium.
Penelitian deskriptif non eksperimental dilakukan dengan pendekatan pengambilan data secara retrospektif di ICU, NICU dan PICU. Data diperoleh dari rekam medik pasien pneumonia tahun 2016 yang memenuhi kriteria yaitu pasien yang didiagnosis pneumonia dengan penyakit penyerta, mendapatkan terapi antibiotik minimal 3 hari, dan memiliki data kultur bakteri. Interaksi obat dianalisis menggunakan Stockley’s Drug Interaction, Drug Interaction Fact, dan Medscape lalu dihitung persentase potensi interkasi, fase dan signifikansi interaksinya.
Hasil penelitian menunjukkan bahwa diantara 28 pasien terdapat 17 jenis obat yang berpotensi menyebabkan interaksi obat pada pasien pneumonia berdasarkan literatur. Persentase interaksi obat pada fase farmakokinetika 80% dan farmakodinamika 20%. Potensi interaksi obat fase farmakokinetik terbagi menjadi 2 fase yaitu metabolisme 44%; ekskresi 36%. Signifikasi interaksi obat yaitu mayor (10%), moderate (80%) dan minor (10%). Sebagian besar obat berpotensi berinteraksi pada fase metabolisme dengan signifikasi moderate. Potensi interaksi obat dengan persentase paling tinggi yaitu gentamycin dengan furosemide dengan signifikansi moderate sebesar 16%.
Aktivitas Analgetik dan Antiinflamasi Fraksi Daun Ashitaba (Angelica keiskei (Miq.) Koidz.) Pada Tikus Jantan Galur Wistar dan Keamanannya Terhadap Lambung
Authors: ROCHMA EKA NDHARI 
Published: May 2022

Ashitaba (Angelica keiskei (Miq.) Koidz.) merupakan salah satu tanaman yang memiliki aktivitas sebagai analgetik dan antiinflamasi. Kandungan senyawa yang diduga berkhasiat adalah flavonoid, saponin, alkaloid, dan tanin. Tujuan dari penelitian ini adalah mengetahui ekstrak dan fraksi memiliki aktivitas analgetik dengan metode hot plate dan tail flick, aktivitas antiinflamasi dengan metode randall-selitto dan pembentukan udema, keamanan terhadap lambung serta mengetahui fraksi yang memberikan aktivitas paling kuat dan aman terhadap lambung tikus.
Ekstrak etanol daun ashitaba difraksinasi dengan pelarut n-heksan, etil asetat, dan air. Uji analgetik dilakukan dengan metode hot plate dan tail flick, uji antiinflamasi dilakukan dengan metode randall-selitto dan pembentukan udema kemudian dilakukan pengamatan keamanan lambung tikus secara makroskopis dan mikroskopis. Dosis ekstrak dan fraksi daun ashitaba berturut-turut yaitu ekstrak 300mg/kgBB, fraksi n-heksan 120,7mg/kgBB, fraksi etil asetat 20,6mg/kgBB, fraksi air 158,65mg/kgBB, kontrol negatif Na CMC 1%, dan asam mefenamat 500mg/kgBB.
Hasil penelitian menunjukkan ekstrak etanol, fraksi n-heksan, fraksi etil asetat, dan fraksi air daun ashitaba memiliki aktivitas sebagai analgetik dan antiinflamasi. Ekstrak 300mg/kgBB dan fraksi n-heksan 120,7mg/kgBB menunjukkan aktivitas analgetik dan antiinflamasi yang setara dengan asam mefenamat dan menunjukkan keamanan pada lambung setara dengan kontrol negatif.
Concentration Analysis of Pb and Cd in Water and Blood Shells (Anadara granosa) in Rupat Strait Water
Authors: Sari Lita , Nasution Syafruddin , Nedi Syahril 
Published: May 2022

Water pollution occurs due to waste from various community activities that produce liquid, solid, and gas waste. One of the wastes produced is heavy metals that are harmful to organisms and humans. The research was conducted in December 2020-March 2021 in the Waters of Rupat Strait of Riau Province. This study aims to analyze the concentration of Pb and Cd metals in water and blood shells (Anadara granosa), know the relationship of Pb and Cd metal concentrations to morphometric blood shells (A. granosa), and know the relationship of Pb and Cd metal content in water and blood shells (A.granosa). The method used in the research is the survey method. The results showed that the concentration value of heavy metals in seawater in the Rupat Strait Waters (Cd 0.11mg/L), (Pb 0.86 mg/L). Concentrations of heavy metals in blood shells (A. granosa) in rupat strait waters ranged Cd (0.04 mg/kg), Pb (0.03-0.06 mg/kg). Based on these results, pb and cd metal in the sea pair in the strait has passed the quality standard set while the Metal Pb and Cd on blood shells are still below the quality standard which means it is still safe to be consumed
IMPROVING THE BENEFITS OF SELF-REGULATION OF THE PSYCHOLOGICAL STATE OF STUDENTS-HOCKEY PLAYERS DURING THE HOUR OF PLAYING ACTIVITY
Authors: Luskan O. , Kuzmenko N. , Zhuravlov S. 
Published: May 2022

The article summarizes the theoretical data and further develops the methodological foundations of self-regulation of the psychological state of hockey students. It is revealed that the conditions for improving the means of self-regulation of the psychological state of hockey students in the process of their playing activities. The peculiarities of self-regulation of the psychological state of hockey students depending on the game role, which is steadily manifested in the game activity, are determined. The results of the study allow to expand the approaches to the problem of managing the psychological state of hockey athletes in the course of their playing activities. Modern science actively uses the methods of mathematical statistics to establish the degree of objectivity and reliability of life processes and ongoing scientific research. This circumstance, to a certain extent, can be attributed to the field of sports. The activities of athletes, sports teams, and the entire field of sports are based on many indicators that require an objective analysis and then adequately made decisions.
The tasks that professional activity sets for a future specialist in the field of physical culture and sports are basically related to the analysis of the influence of random factors and require decision-making under risk, choice and uncertainty based on the possession of mathematical knowledge and skills. An important role in the structure of professional knowledge of a future coach and teacher is played by the identification, forecast, prevention of crisis situations both in the personal formation of an athlete and in the development of communications in a sports team based on metrological data, the use of stochastic analysis methods and the study of probabilistic models of real processes and phenomena.
Peculiarities of training and official activity in the context of special training of future women officers of the National Police of Ukraine
Authors: Dominyuk M. 
Published: May 2022

The article examines the peculiarities of professional training and service activities of future female officers for units of the National Police of Ukraine in higher education institutions with specific training conditions of the Ministry of Internal Affairs, and how specific training conditions for cadets are related to their special training. Research methods: theoretical analysis and generalization of educational and methodical recommendations, Internet resources on research topics, documentary method, method of comparison.
It was found that the high level of physical fitness, which is a component of special training, future female officers of the National Police is closely related to the efficiency of service and success of cadets in higher education with specific training conditions of the Ministry of Internal Affairs. The results of the study indicate the need to increase the level of physical fitness of future female officers during training in higher education institutions of the Ministry of Internal Affairs of Ukraine, which will increase the level of special training of cadets, the quality of education and performance.
Techniques for management and avoidance of ventriculoatrial shunt disconnection: illustrative cases
Authors: Zervos Thomas M. , Kutschman Kenneth , Frisoli Tiberio , Mansour Tarek R. , Schwalb Jason M. 
Published: May 2022

BACKGROUND
Ventriculoatrial (VA) shunt disconnection can result in distal catheter migration into the cardiopulmonary vasculature. There is little guidance in the current literature on how to prevent and manage this uncommon yet potentially serious complication. The authors reviewed the existing literature and described three instances of distal shunt migration VA shunts and offered insight on methods to mitigate such complications.

OBSERVATIONS
Eighteen patients were identified with VA shunts. Of these patients, seven were identified as having a connector in the neck, three of which were associated with distal disconnection and migration. In all three cases, the distal catheter was retrieved via an endovascular approach in conjunction with transesophageal echocardiography to assess for retrieval feasibility.

LESSONS
The authors recommended the avoidance of a straight connector when performing VA shunt placement. When distal catheter migration occurs, collaboration with interventional cardiology is advisable when possible.
Correlation of intraventricular nicardipine for refractory vasospasm in aneurysmal subarachnoid hemorrhage with improved neurophysiology on intracranial multimodality monitoring: illustrative case
Authors: Grandhi Ramesh , Menacho Sarah T. , Ravindra Vijay M. , Condie Chad , Taussky Philipp , Hawryluk Gregory W. J. 
Published: May 2022

BACKGROUND
Cerebral vasospasm after aneurysmal subarachnoid hemorrhage can lead to considerable mortality and morbidity affecting the intracranial vessels, leading to delayed cerebral ischemia and stroke. Therapeutic options for patients with treatment-refractory vasospasm are limited, particularly in the setting of significant cardiopulmonary disease. Administration of nicardipine, a calcium channel blocker, into the intrathecal space may represent a potential treatment option for this population.

OBSERVATIONS
A 56-year-old woman had treatment-refractory vasospasm, severe acute respiratory distress syndrome, and Takotsubo cardiomyopathy. As an adjunct to vasopressor administration and endovascular intraarterial calcium channel blocker administration, the patient received intraventricular nicardipine. The patient demonstrated improved neurophysiology on invasive multimodality neuromonitoring, with increased cerebral blood flow and oxygenation as a result of intraventricular nicardipine administration.

LESSONS
Intraventricular nicardipine can be used as rescue therapy for patients with treatment-refractory cerebral vasospasm. This case demonstrates that intrathecal nicardipine may prevent delayed ischemic neurological deficits and improve outcomes.