bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phonon thermal Hall effect in a metallic spin ice
Authors: Uehara Taiki , Ohtsuki Takumi , Udagawa Masafumi , Nakatsuji Satoru , Machida Yo 
Published: August 2022

AbstractIt has become common knowledge that phonons can generate thermal Hall effect in a wide variety of materials, although the underlying mechanism is still controversial. We study longitudinal κxx and transverse κxy thermal conductivity in Pr2Ir2O7, which is a metallic analog of spin ice. Despite the presence of mobile charge carriers, we find that both κxx and κxy are dominated by phonons. A T/H scaling of κxx unambiguously reveals that longitudinal heat current is substantially impeded by resonant scattering of phonons on paramagnetic spins. Upon cooling, the resonant scattering is strongly affected by a development of spin ice correlation and κxx deviates from the scaling in an anisotropic way with respect to field directions. Strikingly, a set of the κxx and κxy data clearly shows that κxy correlates with κxx in its response to magnetic field including a success of the T/H scaling and its failure at low temperature. This remarkable correlation provides solid evidence that an indispensable role is played by spin-phonon scattering not only for hindering the longitudinal heat conduction, but also for generating the transverse response.
A cognitive neurogenetic approach to uncovering the structure of executive functions
Authors: Feng Junjiao , Zhang Liang , Chen Chunhui , Sheng Jintao , Ye Zhifang , Feng Kanyin , Liu Jing , Cai Ying , Zhu Bi , Yu Zhaoxia , Chen Chuansheng , Dong Qi , Xue Gui 
Published: August 2022

AbstractOne central mission of cognitive neuroscience is to understand the ontology of complex cognitive functions. We addressed this question with a cognitive neurogenetic approach using a large-scale dataset of executive functions (EFs), whole-brain resting-state functional connectivity, and genetic polymorphisms. We found that the bifactor model with common and shifting-specific components not only was parsimonious but also showed maximal dissociations among the EF components at behavioral, neural, and genetic levels. In particular, the genes with enhanced expression in the middle frontal gyrus (MFG) and the subcallosal cingulate gyrus (SCG) showed enrichment for the common and shifting-specific component, respectively. Finally, High-dimensional mediation models further revealed that the functional connectivity patterns significantly mediated the genetic effect on the common EF component. Our study not only reveals insights into the ontology of EFs and their neurogenetic basis, but also provides useful tools to uncover the structure of complex constructs of human cognition.
Elevation of gangliosides in four brain regions from Parkinson’s disease patients with a GBA mutation
Authors: Blumenreich Shani , Nehushtan Tamar , Barav Or B. , Saville Jennifer T. , Dingjan Tamir , Hardy John , Fuller Maria , Futerman Anthony H. 
Published: August 2022

AbstractA number of genetic risk factors have been identified over the past decade for Parkinson’s Disease (PD), with variants in GBA prominent among them. GBA encodes the lysosomal enzyme that degrades the glycosphingolipid, glucosylceramide (GlcCer), with the activity of this enzyme defective in Gaucher disease. Based on the ill-defined relationship between glycosphingolipid metabolism and PD, we now analyze levels of various lipids by liquid chromatography/electrospray ionization-tandem mass spectrometry in four brain regions from age- and sex-matched patient samples, including idiopathic PD, PD patients with a GBA mutation and compare both to control brains (n = 21 for each group) obtained from individuals who died from a cause unrelated to PD. Of all the glycerolipids, sterols, and (glyco)sphingolipids (251 lipids in total), the only lipid class which showed significant differences were the gangliosides (sialic acid-containing complex glycosphingolipids), which were elevated in 3 of the 4 PD-GBA brain regions. There was no clear correlation between levels of individual gangliosides and the genetic variant in Gaucher disease [9 samples of severe (neuronopathic), 4 samples of mild (non-neuronopathic) GBA variants, and 8 samples with low ﻿pathogenicity variants which have a higher risk for development of PD]. Most brain regions, i.e. occipital cortex, cingulate gyrus, and striatum, did not show a statistically significant elevation of GlcCer in PD-GBA. Only one region, the middle temporal gyrus, showed a small, but significant elevation in GlcCer concentration in PD-GBA. We conclude that changes in ganglioside, but not in GlcCer levels, may contribute to the association between PD and GBA mutations.
A global dataset of seaweed net primary productivity
Authors: Pessarrodona Albert , Filbee-Dexter Karen , Krumhansl Kira A. , Pedersen Morten F. , Moore Pippa J. , Wernberg Thomas 
Published: August 2022

AbstractNet primary productivity (NPP) plays a pivotal role in the global carbon balance but estimating the NPP of underwater habitats remains a challenging task. Seaweeds (marine macroalgae) form the largest and most productive underwater vegetated habitat on Earth. Yet, little is known about the distribution of their NPP at large spatial scales, despite more than 70 years of local-scale studies being scattered throughout the literature. We present a global dataset containing NPP records for 246 seaweed taxa at 429 individual sites distributed on all continents from the intertidal to 55 m depth. All records are standardized to annual aerial carbon production (g C m−2 yr−1) and are accompanied by detailed taxonomic and methodological information. The dataset presented here provides a basis for local, regional and global comparative studies of the NPP of underwater vegetation and is pivotal for achieving a better understanding of the role seaweeds play in the global coastal carbon cycle.
CRITTERBASE, a science-driven data warehouse for marine biota
Authors: Teschke Katharina , Kraan Casper , Kloss Paul , Andresen Henrike , Beermann Jan , Fiorentino Dario , Gusky Manuela , Hansen Miriam L. S. , Konijnenberg Rebecca , Koppe Roland , Pehlke Hendrik , Piepenburg Dieter , Sabbagh Tawfik , Wrede Alexa , Brey Thomas , Dannheim Jennifer 
Published: August 2022

AbstractData on marine biota exist in many formats and sources, such as published literature, data repositories, and unpublished material. Due to this heterogeneity, information is difficult to find, access and combine, severely impeding its reuse for further scientific analysis and its long-term availability for future generations. To address this challenge, we present CRITTERBASE, a publicly accessible data warehouse and interactive portal that currently hosts quality-controlled and taxonomically standardized presence/absence, abundance, and biomass data for 18,644 samples and 3,664 benthic taxa (2,824 of which at species level). These samples were collected by grabs, underwater imaging or trawls in Arctic, North Sea and Antarctic regions between the years 1800 and 2014. Data were collated from literature, unpublished data, own research and online repositories. All metadata and links to primary sources are included. We envision CRITTERBASE becoming a valuable and continuously expanding tool for a wide range of usages, such as studies of spatio-temporal biodiversity patterns, impacts and risks of climate change or the evidence-based design of marine protection policies.
Intracellular production of reactive oxygen species and a DAF-FM-related compound in Aspergillus fumigatus in response to antifungal agent exposure
Authors: Oiki Sayoko , Nasuno Ryo , Urayama Syun-ichi , Takagi Hiroshi , Hagiwara Daisuke 
Published: August 2022

AbstractFungi are ubiquitously present in our living environment and are responsible for crop and infectious diseases. Developing new antifungal agents is constantly needed for their effective control. Here, we investigated fungal cellular responses to an array of antifungal compounds, including plant- and bacteria-derived antifungal compounds. The pathogenic fungus Aspergillus fumigatus generated reactive oxygen species in its hyphae after exposure to the antifungal compounds thymol, farnesol, citral, nerol, salicylic acid, phenazine-1-carbonic acid, and pyocyanin, as well as under oxidative and high-temperature stress conditions. The production of nitric oxide (NO) was determined using diaminofluorescein-FM diacetate (DAF-FM DA) and occurred in response to antifungal compounds and stress conditions. The application of reactive oxygen species or NO scavengers partly suppressed the inhibitory effects of farnesol on germination. However, NO production was not detected in the hyphae using the Greiss method. An LC/MS analysis also failed to detect DAF-FM-T, a theoretical product derived from DAF-FM DA and NO, in the hyphae after antifungal treatments. Thus, the cellular state after exposure to antifungal agents may be more complex than previously believed, and the role of NO in fungal cells needs to be investigated further.
Vacuum curette lumbar discectomy mechanics for use in spine surgical training simulators
Authors: Cotter Trevor , Mongrain Rosaire , Driscoll Mark 
Published: August 2022

AbstractSimulation in surgical training is a growing field and this study aims to understand the force and torque experienced during lumbar spine surgery to design simulator haptic feedback. It was hypothesized that force and torque would differ among lumbar spine levels and the amount of tissue removed by ≥ 7%, which would be detectable to a user. Force and torque profiles were measured during vacuum curette insertion and torsion, respectively, in multiple spinal levels on two cadavers. Multiple tests per level were performed. Linear and torsional resistances of 2.1 ± 1.6 N/mm and 5.6 ± 4.3 N mm/°, respectively, were quantified. Statistically significant differences were found in linear and torsional resistances between all passes through disc tissue (both p = 0.001). Tool depth (p < 0.001) and lumbar level (p < 0.001) impacted torsional resistance while tool speed affected linear resistance (p = 0.022). Average differences in these statistically significant comparisons were ≥ 7% and therefore detectable to a surgeon. The aforementioned factors should be considered when developing haptic force and torque feedback, as they will add to the simulated lumbar discectomy realism. These data can additionally be used inform next generation tool design. Advances in training and tools may help improve future surgeon training.
Ancient DNA reveals phenological diversity of Coast Salish herring harvests over multiple centuries
Authors: Petrou Eleni L. , Kopperl Robert , Lepofsky Dana , Rodrigues Antonia T. , Yang Dongya , Moss Madonna L. , Speller Camilla F. , Hauser Lorenz 
Published: August 2022

AbstractPhenological diversity in food resources prolongs foraging opportunities for consumers and buffers them against environmental disturbances. Such diversity is particularly important in forage fish such as Pacific herring (Clupea pallasii), which are foundational to coastal food webs and fisheries. While the importance of phenological diversity is well-known from contemporary studies, the extent to which different populations contribute to fisheries over long time scales is mostly unknown. In this study, we investigated the relative contributions of genetically and phenologically distinct herring populations to Indigenous Peoples’ food systems over multiple centuries, using ancient DNA extracted from archaeological herring bones. These bones were excavated from two Coast Salish archaeological sites (Burton Acres Shell Midden and Bay Street Shell Midden) in the Puget Sound region, USA. Using genetic stock identification from seven nuclear DNA markers, we showed that catches at the two sites in central Puget Sound were dominated by January–February and March–April spawners, which are the contemporary spawning groups in the vicinity of the sites. However, May spawners were detected in the older Burton Acres assemblage (dated to 910–685 cal BP), and a mixed stock analysis indicated that catches at this site consisted of multiple populations. These results suggest that Coast Salish ancestors used a portfolio of herring populations and benefited from the ecological resource wave created by different spawning groups of herring. This study of ancient DNA allowed us to glimpse into Indigenous traditional food and management systems, and it enabled us to investigate long-term patterns of biodiversity in an ecologically important forage fish species.
Associations between ultrasound screening findings and cholangiocarcinoma diagnosis in an at-risk population
Authors: Thinkhamrop Kavin , Khuntikeo Narong , Chamadol Nittaya , Suwannatrai Apiporn T. , Phimha Surachai , Kelly Matthew 
Published: August 2022

AbstractThe rate of cholangiocarcinoma (CCA) is increasing every year, especially in northeastern Thailand. Screening for CCA using ultrasonography (US) is the fastest technique to identify patients in early stage of CCA development. Currently, few studies have examined patterns of hepatobiliary abnormalities identified using US, which can be indicative of CCA. We aim to evaluate the rate of CCA and its relations to history of US findings. Our study included participants who underwent US and pathological diagnosis of CCA from the Cholangiocarcinoma Screening and Care Program, Northeast Thailand between 2013 and 2020. Data on histological findings were based on the standard protocol of the tertiary hospital at Khon Kaen University. CCA data is categorized into two groups (yes/no) to find the relationship with history of US findings. The adjusted odds ratio (AOR) and their 95% confidence intervals (CI) were used to evaluate the relationship obtained by multiple logistic regression. Of 1880 subjects who underwent US and a pathological diagnosis of CCA, the overall rate of CCA was 35.74%. CCA rate among those with liver mass (LM) was 54.85% and with dilated bile duct (DBD) was 62.01%. The relationship between DBD and CCA was highly significant (AOR = 3.46; 95% CI 2.74–4.36) followed by LM (AOR = 2.28; 95% CI 1.81–2.86) P value < 0.001. Our study reveals that US findings history have a strong association with CCA, especially in people diagnosed with DBD and LM. Therefore, these abnormalities can be indicators for suspected CCA diagnosis through US.
Three pairs of surrogate redox partners comparison for Class I cytochrome P450 enzyme activity reconstitution
Authors: Liu Xiaohui , Li Fengwei , Sun Tianjian , Guo Jiawei , Zhang Xingwang , Zheng Xianliang , Du Lei , Zhang Wei , Ma Li , Li Shengying 
Published: August 2022

AbstractMost P450s require redox partners for the electron transfer during catalysis. However, little information is available on cognate redox partners for P450s, which greatly limits P450 function exploration and practical application. Thus, the stategy of building various hybrid P450 catalytic systems with surrogate redox partner has often adopted to engineer P450 biocatalysts. In this study, we compare three pairs of frequently-used surrogate redox partner SelFdx1499/SelFdR0978, Adx/AdR and Pdx/PdR and in terms of their electron transfer properties. The three selected bacterial Class I P450s include PikC, P450sca-2 and CYP-sb21, which are responsible for production of high-value-added products. Here we show that SelFdx1499/SelFdR0978 is the most promising redox partner compared to Adx/AdR and Pdx/PdR. The results provide insights into the domination for P450-redox partner interactions in modulating the catalytic activity of P450s. This study not only produces a more active biocatalyst but also suggests a general chose for a universal reductase which would facilitate engineering of P450 catalyst.
mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
Authors: Nanishi Etsuro , McGrath Marisa E. , O’Meara Timothy R. , Barman Soumik , Yu Jingyou , Wan Huahua , Dillen Carly A. , Menon Manisha , Seo Hyuk-Soo , Song Kijun , Xu Andrew Z. , Sebastian Luke , Brook Byron , Bosco Anna-Nicole , Borriello Francesco , Ernst Robert K. , Barouch Dan H. , Dhe-Paganon Sirano , Levy Ofer , Frieman Matthew B. , Dowling David J. 
Published: August 2022

AbstractThe SARS-CoV-2 Omicron variant evades vaccine-induced immunity. While a booster dose of ancestral mRNA vaccines effectively elicits neutralizing antibodies against variants, its efficacy against Omicron in older adults, who are at the greatest risk of severe disease, is not fully elucidated. Here, we evaluate multiple longitudinal immunization regimens of mRNA BNT162b2 to assess the effects of a booster dose provided >8 months after the primary immunization series across the murine lifespan, including in aged 21-month-old mice. Boosting dramatically enhances humoral and cell-mediated responses with evidence of Omicron cross-recognition. Furthermore, while younger mice are protected without a booster dose, boosting provides sterilizing immunity against Omicron-induced lung infection in aged 21-month-old mice. Correlational analyses reveal that neutralizing activity against Omicron is strongly associated with protection. Overall, our findings indicate age-dependent vaccine efficacy and demonstrate the potential benefit of mRNA booster immunization to protect vulnerable older populations against SARS-CoV-2 variants.
Neuronal Bmal1 regulates retinal angiogenesis and neovascularization in mice
Authors: Jidigam Vijay K. , Sawant Onkar B. , Fuller Rebecca D. , Wilcots Kenya , Singh Rupesh , Lang Richard A. , Rao Sujata 
Published: August 2022

AbstractCircadian clocks in the mammalian retina regulate a diverse range of retinal functions that allow the retina to adapt to the light-dark cycle. Emerging evidence suggests a link between the circadian clock and retinopathies though the causality has not been established. Here we report that clock genes are expressed in the mouse embryonic retina, and the embryonic retina requires light cues to maintain robust circadian expression of the core clock gene, Bmal1. Deletion of Bmal1 and Per2 from the retinal neurons results in retinal angiogenic defects similar to when animals are maintained under constant light conditions. Using two different models to assess pathological neovascularization, we show that neuronal Bmal1 deletion reduces neovascularization with reduced vascular leakage, suggesting that a dysregulated circadian clock primarily drives neovascularization. Chromatin immunoprecipitation sequencing analysis suggests that semaphorin signaling is the dominant pathway regulated by Bmal1. Our data indicate that therapeutic silencing of the retinal clock could be a common approach for the treatment of certain retinopathies like diabetic retinopathy and retinopathy of prematurity.
Photogenerated hole traps in metal-organic-framework photocatalysts for visible-light-driven hydrogen evolution
Authors: Lian Zichao , Li Zhao , Wu Fan , Zhong Yueqi , Liu Yunni , Wang Wenchao , Zi Jiangzhi , Yang Weiwei 
Published: August 2022

AbstractEfficient electron-hole separation and carrier utilization are key factors in photocatalytic systems. Here, we use a metal-organic framework (NH2-UiO-66) modified with inner platinum nanoparticles and outer cadmium sulfide (CdS) nanoparticles to construct the ternary composite Pt@NH2-UiO-66/CdS, which has a spatially separated, hierarchical structure for enhanced visible-light-driven hydrogen evolution. Relative to pure NH2-UiO-66, Pt@NH2-UiO-66, and NH2-UiO-66/CdS samples, the Pt@NH2-UiO-66/CdS composite exhibits much higher hydrogen yields with an apparent quantum efficiency of 40.3% at 400 nm irradiation and stability over the most MOF-based photocatalysts. Transient absorption measurements reveal spatial charge-separation dynamics in the composites. The catalyst’s high activity and durability are attributed to charge separation following an efficient photogenerated hole-transfer band-trap pathway. This work holds promise for enhanced MOF-based photocatalysis using efficient hole-transfer routes.
Remote learning slightly decreased student performance in an introductory undergraduate course on climate change
Authors: Ghosh Sattik , Pulford Stephanie , Bloom Arnold J. 
Published: August 2022

AbstractPublic understanding about complex issues such as climate change relies heavily on online resources. Yet the role that online instruction should assume in post-secondary science education remains contentious despite its near ubiquity during the COVID-19 pandemic. The objective here was to compare the performance of 1790 undergraduates taking either an online or face-to-face version of an introductory course on climate change. Both versions were taught by a single instructor, thus, minimizing instructor bias. Women, seniors, English language learners, and humanities majors disproportionately chose to enroll in the online version because of its ease of scheduling and accessibility. After correcting for performance-gaps among different demographic groups, the COVID-19 pandemic had no significant effect on online student performance and students in the online version scored 2% lower (on a scale of 0–100) than those in the face-to-face version, a penalty that may be a reasonable tradeoff for the ease of scheduling and accessibility that these students desire.
Predefined‐time guaranteed performance attitude tracking control for uncertain rigid spacecraft
Authors: Wang Zeng , Ma Jun , Wang Chang 
Published: August 2022

AbstractThis paper addresses the predefined‐time guaranteed performance attitude tracking for rigid spacecraft with inertia uncertainties and bounded external disturbances. Firstly, a novel non‐singular predefined‐time terminal sliding mode (NPTSM) surface with the prescribed performance tracking errors is constructed. Secondly, a NPTSM control (NPTSMC) is designed to solve the robust predefined‐time attitude tracking problem. It is proved that the proposed control can ensure that the attitude tracking error satisfies the prescribed performance boundaries all the time and converges to a preset small region centred around the equilibrium point within predefined time and then converges to the equilibrium point asymptotically. The appealing feature of the proposed control is predefined‐time stability with faster transient performance quantified and higher steady‐state accuracy. Simulations verify the effectiveness and improved performance of the proposed approach.
Prospects and challenges of Metaverse application in data‐driven intelligent transportation systems
Authors: Njoku Judith Nkechinyere , Nwakanma Cosmas Ifeanyi , Amaizu Gabriel Chukwunonso , Kim Dong‐Seong 
Published: August 2022

AbstractThe Metaverse is a concept used to refer to a virtual world that exists in parallel to the physical world. It has grown from a conceptual level to having real applications in virtual reality games. The applicability of the Metaverse in numerous sectors like marketing, education, social, and even advertising exists. However, there exists little or no work on Metaverse applicability to the transportation industry. Data‐driven intelligent transportation systems (DDITS) aim to provide more intelligent systems based on exploiting data. This paper reviews the concepts and features of the Metaverse. Also, the review goes over three dominant DDITS challenges: vehicle fault detection and repair, testing new technologies, and anti‐theft systems. In addition, it highlights prospective Metaverse solutions that apply to the DDITS. Buttressing the utility of Metaverse in DDITS, this paper presents two major case studies: the invisible to visible (I2V) and the Metaverse on Wheels (MoW) technologies. Finally, the influence, limitations, and open issues of Metaverse applications to DDITS are discussed.