bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doctors in distress: The personality profile of derailing doctors
Authors: Joffe Megan , Grover Simmy , King Jenny , Furnham Adrian 
Published: February 2022

Objective: This study looked at the bright and dark-side personality profile of distressed and potentially derailing doctors (82% male). The derailing doctors were on average 48.75 years old, and from many specialities, in particular, general practice and surgery. Method: In all, a group of 77 derailing British doctors, and a control group of 357 doctors completed a valid multi-dimensional test of bright-side (normal) personality (NEO-PI-R) and one of dysfunctional interpersonal themes (sub-clinical personality disorders) (HDS: Hogan Development Survey). Results: Controlling for sex and age, the derailing doctors were more Neurotic (less resilient), and less Agreeable, Conscientious, Extraverted and Open-to- Experience. They were also more Excitable (Borderline), Sceptical (Paranoid), Cautious (Avoidant), Reserved (Schizoid), Leisurely (Passive Aggressive) and Bold (Narcissistic). Discriminant analysis showed age, Neuroticism, Extraversion, Leisurely and Excitable were, in that order, the greatest personality discriminators between those who did and did not derail. Conclusion: More research needs to be done on doctor derailment to inform the selection and training of doctors.
Firearm Dealers and Local Gun Violence: A Street Network Analysis of Shootings and Concentrated Disadvantage in Atlanta
Authors: Semenza Daniel C. , Griffiths Elizabeth , Xu Jie , Stansfield Richard 
Published: February 2022

Objectives Examine the spatial relationship between firearm dealers and shootings in Atlanta. Methods We combine data from the Atlanta Police Department (APD), the Bureau of Alcohol, Tobacco, Firearms, and Explosives (ATF), and the American Community Survey (ACS) to conduct a street network analysis from 2016 through 2018. We employ the Network Cross K Function to assess whether firearm dealers attract shootings in the city. We examine whether this spatial relationship differs by level of concentrated disadvantage in neighborhoods. Results Without consideration of concentrated neighborhood disadvantage, firearm dealers and shootings are spatially unrelated to one another. Tract-level disadvantage influences the relationship between firearm dealers and shootings wherein dealers significantly attract shootings in disadvantaged neighborhoods. Conversely, shootings are located further from gun stores in non-disadvantaged communities. Shootings related to manslaughter and assault, but not robbery, are spatially associated with firearm dealers in disadvantaged neighborhoods. Conclusions Building on prior research regarding firearm dealers and gun violence, we find support for an attraction effect in disadvantaged neighborhoods for certain types of shootings. We contextualize these findings within a broader discussion of how firearm dealers contribute to the complex ecology of local gun violence. This is important in light of federal policies and investments related to the prevention of and response to gun crime.
Availability of Essential Antidotes and the Role of Community Pharmacists in the Management of Acute Poisoning: A Cross-Sectional Study in Ethiopia
Authors: Kifle Zemene Demelash , Yimenu Dawit Kumilachew , Demeke Chilot Abiyu , Kasahun Asmamaw Emagn , Siraj Ebrahim Abdela , Wendalem Adane Yehualaw , Bazezew Zegaye Agmassie , Mekuria Abebe Basazn 
Published: February 2022

Background Morbidity and mortality related to acute poisoning is a major public health issue in both developing and developed countries. Community pharmacists have a crucial role in ensuring drug availability, increasing drug safety, counseling patients, overdose risk reduction and management, and provision of appropriate drug information. This study aimed to assess the availability of necessary antidotes in community pharmacies in Gondar and Bahir-Dar cities, Ethiopia, and the role of community pharmacists in the management of acute poisoning. Methods A cross-sectional survey was conducted in Gondar and Bahir-Dar cities. A self-administered, structured questionnaire was used for data collection and Statistical Package for Social Sciences (SPSS) version 24.0 was used for data analysis. Chi-square analysis was computed to identify the associated factors with a confidence interval of 95% and a P value less than .05 was used as a cut-point for statistical significance. Results Out of 101 community pharmacies invited to participate in the study, 80 of them completed the survey with a response rate of 79.2%. The overall mean antidote availability score was .59 (SD = .837), which falls within the definition of Poor availability. None of the pharmacies had kept all of the antidotes, and the maximum number of an antidote kept by a single pharmacy was 7 out of nineteen essential antidotes surveyed. The most commonly reported reason for the unavailability of essential antidotes was stock was not ordered (56.3%) followed by stock ordered but not delivered from suppliers (wholesalers) (20.0%). More than 3 fourth of the respondents (83.8%) had poor knowledge about the antidotes for the common poisonings. Conclusion There was a significantly very low availability of essential antidotes in the community pharmacies. Strategies should be implemented to improve pharmacist’s knowledge about antidotes, and management of poisoning emergencies through on-job training and provision of reference materials.
Automated ASPECTS in acute ischemic stroke: comparison of the overall scores and Hounsfield unit values of two software packages and radiologists with different levels of experience
Authors: Li Xiang , Zhen Yanling , Liu Huan , Zeng Wenbing , Li Yige , Liu Ling , Yang Ran 
Published: February 2022

Background ASPECTS is a simple, rapid, and semi-quantitative method for detecting early ischemic changes (EIC). However, the agreement between software applications and neuroradiologists varies greatly. Purpose To compare ASPECTS calculated by using automated software tools to neuroradiologists evaluation in patients with acute ischemic stroke (AIS). Material and Methods Retrospectively, 61 patients with large vessel occlusion (LVO) who underwent multimodal stroke computed tomography (CT) were evaluated using two automated ASPECTS software tools (NSK and RAPID) and three neuroradiologists with different experiences (two senior neuroradiologists and one junior neuroradiologist). Four weeks later, the same three neuroradiologists re-evaluated the ASPECTS in consensus using the baseline CT and follow-up non-contrast CT (NCCT). Interclass correlation coefficients (ICCs) and Pearson correlation coefficients were applied for statistical analysis. Results The HU value exhibited the greatest correlation in the insular lobe ( r = 0.81; P < 0.001) and the lowest correlation in the internal capsule ( r = 0.65; P < 0.001) between NSK and RAPID. Software analysis and human readers showed excellent agreement with the consensus reading. Compared with the consensus reading, the correlation of the two senior radiologists (ICC = 0.975 and 0.969, respectively) were higher than that of junior radiologist (ICC = 0.869), and the consistency values of the NSK and RAPID software tools after 6 h of onset to imaging (ICC = 0.894 and 0.874, respectively) were greater than those within 6 h of onset (ICC = 0.746 and 0.828, respectively). Conclusion For patients experiencing AIS due to LVO, the ASPECTS calculated with automated software agrees well with the predefined consensus score but is inferior to that of senior radiologists.
Differences in clinical features and prognosis between orbit adenoid cystic carcinoma and adenocarcinoma: a study from the SEER 18 database
Authors: Liu Rui , Li Jing , Zhang Xuan , Ge Xin , Ma Jianmin 
Published: February 2022

Purpose: To analyze the differences in clinical features, treatment methods, prognosis, and etiological factors between lacrimal gland, adenoid cystic carcinoma (LGACC), and orbit adenocarcinoma. Material and Methods: All cases of LGACC and orbit adenocarcinoma between 1975 and 2016 were obtained from the US National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database. Results: The 3-, 5-, and 10-year overall survival (OS) rates for 118 LGACC cases were 82.2%, 70.2%, and 51.7%, respectively. The 3-, 5-, and 10-year OS rates for 29 orbit adenocarcinoma cases were 76.3%, 51.2%, and 51.2%, respectively. There was no statistically significant difference in the overall survival rate between LGACC and adenocarcinoma (P=0.566). Univariate analysis showed that the proportion of deaths was higher with increased age and year of diagnosis in LGACC (P=0.010 and P=0.000), while the death rate was higher for poorly differentiated adenocarcinoma (P=0.020). The survival rate for LGACC was lower in patients ⩾60 years of age than in those <60 years of age (P=0.035). There was no significant difference in survival rate between adenocarcinoma patients ⩾60 years and <60 years old (P=0.102). There was no significant correlation between the degree of tumor differentiation and the survival rate for LGACC or adenocarcinoma (P=0.401 or P=0.098, respectively). Conclusion: There is no significant difference in prognosis between LGACC and adenocarcinoma. The degree of tumor differentiation is not associated with prognosis for either LGACC or adenocarcinoma.
Childbearing Biographies and Midlife Women’s Health
Authors: Thomeer Mieke Beth , Reczek Rin , Ross Clifford 
Published: February 2022

Objectives We introduce a “childbearing biography” approach to show how multiple childbearing characteristics cluster in ways significant for midlife health. Methods We analyze the National Longitudinal Survey of Youth 1979 (NLSY79; N = 3992) using mixed-mode Latent Class Analysis with eight childbearing variables (e.g., age at first birth, parity, birth spacing, and mistimed births) to identify how childbearing biographies are associated with midlife health, adjusting for key covariates—including socioeconomic status (SES) and relationship history. Results We identify six childbearing biographies: (1) early compressed, (2) staggered, (3) extended high parity, (4) later, (5) married planned, and (6) childfree. Childbearing biographies are strongly associated with physical health but not mental health, with differences primarily explained by SES. Discussion Different childbearing biographies are related to physical health inequalities above what is demonstrated by the typical use of one or two childbearing measures, providing a new perspective into the growing health gap among aging midlife women.
Virologic failure in people living with HIV in 1st line ART: A 10-year Mexican population-based study
Authors: Azamar-Alonso Amilcar , Mbuagbaw Lawrence , Smaill Fiona , Bautista-Arredondo Sergio A , Costa Andrew P , Tarride Jean-Eric 
Published: February 2022

Background In Mexico, the number of people living with HIV (PLWH) receiving antiretroviral therapy (ART) has increased in the last 20 years. The elimination of a CD4 threshold to initiate publicly funded ART was a major policy implemented in 2014. The study objective was to assess the determinants of Virologic Failure (VF) in Mexican PLWH on first-line ART between 2008 and 2017 and to evaluate the effects of changes following the 2014 policy. Methods A 10-year patient-level data analysis was conducted using the Mexican SALVAR database. The main outcome was the proportion of PLWH with VF. A multivariable logistic regression was conducted to identify the association between covariates and VF before and after the 2014 policy implementation. Results We found a lower proportion of people with VF in 2014–2017 compared with 2008–2013 (50% vs 33%, p<0.001). The multivariable analysis showed a reduction in the odds of virologic failure after 2014 (Odds ratio: 0.50 [95% CI: 0.48–0.51]). Place of treatment and level of deprivation were significant predictors of VF in during 2014–2017, but not before. Conclusion This study indicates that, by lowering threshold levels of CD4 required for treatment initiation in Mexico, a higher number of PLWH initiated treatment during 2014–2017, compared to 2008–2013 and the odds of VF were reduced.
Informed consent, genomic research and mental health: A integrative review
Authors: Kilkku Nina , Halkoaho Arja 
Published: February 2022

Background Research on genomics has increased while the biobank activities are becoming more common in different countries. In the mental health field, the questions concerning the potential participants’ vulnerability as well as capacity to give the informed consent can cause reluctancy in recruiting persons with mental health problems, although the knowledge and understanding of mental health problems has remarkable changed, and practice is guided with inclusive approaches, such as recovery approach. Aim The aim of this study was to describe the current knowledge of informed consent practices in the context of genomic research on mental health from the nurses’ viewpoint. Methods An integrative review was conducted with search from seven international databases. Data consist 14 publications which were analyzed with thematic analysis. Ethical considerations Ethical requirements were respected in every phase of the research process. Findings Most of the papers were published in USA and between 2000–2010. Eight reports were categorized as discussion papers, four qualitative studies and one quantitative study. The thematic analysis provided information on five themes: complexity with the capacity to consent, mixed emotions towards participation, factors influencing the decision to participate, nurses’ informed consent process competence and variations between consent procedures. Discussion In the informed consent practices, there are various aspects which may affect both the willingness to participate in the study and the informed consent process itself. Implications for practice, education, research, and policies are discussed. Conclusion There is a need for more updated international research on the topic in the context of different international and national guidelines, legislation, and directives. This study provided a viewpoint to the more collaborative research activities with people with lived experiences also in this field of research following the ideas of recovery approach.
Complete metabolic response after carboplatin desensitization in Peritoneal Carcinomatosis
Authors: Villarreal-González Rosalaura V , González-Díaz Sandra N , Vidal-Gutiérrez Oscar , Zayas-Villanueva Omar A , Solís-Lara Hugo , Santos-Fernández Wendy J , Casas-Murillo Claudio A , López-Méndez Alfonso 
Published: February 2022

Introduction High-grade serous primary peritoneal cancer is highly sensitive to platinum-based chemotherapy with response rates above 80%. Incidence of immediate hypersensitivity reactions to carboplatin is estimated to be between 15% and 20%, usually seen after a mean of 6–8 infusions, with patients developing moderate to severe reactions. Case report A 62-year-old female patient with stage IIIC primary high-grade serous carcinoma of the peritoneum was diagnosed and chemotherapy with carboplatin and Paclitaxel was indicated by the oncology service and patient shows response. At 6 months the patient returns, a new PET/CT reports progression of the disease. Carboplatin/paclitaxel cycles are restarted and in the eight cycle of carboplatin within 40 min of administration, she presented severe anaphylaxis with skin, pulmonary, cardiac and atypical symptoms. Infusion is suspended and intramuscular epinephrine with hydrocortisone and chlorphenamine are administered resolving symptoms. Management and outcome Intradermal skin test with carboplatin at the concentration of 10 mg / ml (dilution 1: 100) was positive. Due to the symptoms presented and to continue the safe reintroduction to carboplatin, a 4 bag 16-step drug desensitization protocol was carried out at a total dose of 620 mg with no hypersensitivity reactions. Discussion Prolonged carboplatin use is associated with an increased incidence of carboplatin-related hypersensitivity reactions. And in patients that present hypersensitivity reactions, a safe and effective carboplatin desensitization protocol can be carried out to reach the administration of a full dose. Desensitization protocol induces tolerance to a drug temporarily and is dependent on continuous exposure.
The Mediating Roles of Mental Health and Substance Use on Suicidal Behavior Among Undergraduate Students With ADHD
Authors: Brown Natasha , McLafferty Margaret , O’Neill Siobhan M. , McHugh Rachel , Ward Caoimhe , McBride Louise , Brady John , Bjourson Anthony J. , Walsh Colum P. , Murray Elaine K. 
Published: February 2022

Objective: To evaluate the prevalence of suicidal ideation (SI), plans and attempts, and non-suicidal self-injury (NSSI) among students with attention deficit hyperactivity disorder (ADHD). Furthermore, we explored the mediating effects of depression, anxiety, alcohol and substance use on the association between ADHD and suicidal behaviors and NSSI. Method: Participants were first-year undergraduate students ( n = 1,829) recruited as part of the World Mental Health International College Student Initiative. Participants completed validated clinical measures online. Results: The prevalence of suicide behaviors and NSSI were significantly higher among students with ADHD than those without. Mediation analyses indicated that ADHD directly and indirectly increased suicidal behaviors and NSSI. While ADHD increased suicidal behaviors and NSSI through depression, ADHD and the co-variates age and gender also had indirect effects on suicidal behaviors via substance use. Conclusions: Specific predictors of risk were identified for students with ADHD which may inform the development of more targeted mental health and suicide prevention strategies across campuses.
The American College of Surgeons National Surgical Quality Improvement Program surgical risk calculator is not reliable in predicting complications and length of stay after primary total hip arthroplasty at an institution implementing clinical pathways
Authors: Manhabusqui Pacífico Jr Giovani , Viamont-Guerra Maria-Roxana , Antonioli Eliane , Paião Isabela Dias , Saffarini Mo , Pereira Guimarães Rodrigo 
Published: February 2022

Introduction: The authors aimed to: (1) determine how length of stay (LOS) and complication rates changed over the past 10 years, in comparison to values estimated by the ACS-NSQIP surgical risk calculator, at a single private institution open to external surgeons; and (2) determine preoperative patient factors associated with complications. Methods: We retrospectively assessed 1018 consecutive patients who underwent primary elective THA over 10 years. We excluded 87 with tumours and 52 with incomplete records. Clinical data of the remaining 879 were used to determine real LOS and rate of 9 adverse events over time, as well as to estimate these values using the risk calculator. Its predictive reliability was represented on receiver operating characteristic curves. Multivariable analyses were performed to determine associations of complications with age, sex, ASA score, diabetes, hypertension, heart disease, smoking and BMI. Results: Over the 10-year period, real LOS and real complication rates decreased considerably, while LOS and complication rates estimated by the surgical risk calculator had little or no change. The difference between real and estimated LOS decreased over time. The overall estimated and real rates of any complication were respectively 3.3% and 2.8%. The risk calculator had fair reliability for predicting any complications (AUC 0.72). Overall estimated LOS was shorter than the real LOS in 764 (86.9%) patients. Multivariable analysis revealed risks of any complication to be greater in patients aged ⩾75 (OR = 4.36, p = 0.002), and with hypertension (OR = 3.13, p = 0.016). Conclusions: Since the implementation of clinical pathways at our institution, real LOS and complication rates decreased considerably, while LOS and complication rates estimated by the surgical risk calculator had little or no change. The difference between real and estimated LOS decreased over time, which could lead some clinicians to reconsider their discharge criteria, knowing that advanced age and hypertension increased risks of encountering complications.
Dolutegravir/rilpivirine 2-drug regimen comparable to commonly prescribed 3-drug regimens up to 18-months in a real-world setting
Authors: Pierone Gerald , Fusco Jennifer S , Vannappagari Vani , Brunet Laurence , Weber Rachel P , Aboud Michael , van Wyk Jean , Ragone Leigh , Fusco Gregory P 
Published: February 2022

Background This study compared the effectiveness and durability of DTG/RPV with commonly prescribed 3-drug regimens (3-DR) in people living with HIV (PLWH) in a real-world setting. Methods Antiretroviral therapy (ART)-experienced, virologically suppressed PLWH who initiated DTG/RPV or a 3-DR in 2018 were identified in the OPERA® database and followed through 6/30/2019. Virologic failure (two consecutive viral loads (VL) ≥ 200 copies/mL or single VL ≥ 200 copies/mL with regimen modification/discontinuation) and maintained virologic suppression (last VL test < 50 or < 200 copies/mL) were described. Kaplan–Meier methods were used to estimate time to virologic failure and treatment discontinuation. Risk of virologic failure was adjusted for age, sex, race/ethnicity, risk of infection, region, baseline CD4 cell count, history of substance abuse or syphilis, and mortality risk score at baseline in a Cox model. Results PLWH initiating DTG/RPV were older and more likely to be Hispanic or have comorbidities than 3-DR initiators. DTG/RPV users experienced fewer discontinuations (15%) and were more likely to be suppressed at study end (98%) than 3-DR users (28% and 96%, respectively). Virologic failure was uncommon; rates per 100 person-years did not differ between the DTG/RPV (1.45, 95% CI: 0.69, 3.03) and 3-DR (2.63, 95% CI: 2.21, 3.14) groups. The risk of virologic failure did not differ significantly between the groups in adjusted Cox models (adjusted hazard ratio 1.32, 95% CI: 0.61, 2.89). Conclusions The findings of this real-world OPERA® study suggest that DTG/RPV can be a viable alternative to standard 3-DRs for ART-experienced, virologically suppressed PLWH.
Unexpected Bare Metal Stent Migration Associated With Aortic Remodeling After PETTICOAT Technique for Aortic Dissection
Authors: Kobayashi Kimihiro , Yamashita Atsushi , Kuroda Yoshinori , Nakai Shingo , Arai Shusuke , Uchida Tetsuro 
Published: February 2022

Purpose: To report a unique case of bare metal stent migration in the overlapping zone and subsequent distal stent graft-induced new entry (SINE) after the Provisional Extension to Induce a Complete Attachment (PETTICOAT) technique for aortic dissection. Case report: A 67-year-old man underwent thoracic endovascular aortic repair (TEVAR) using the PETTICOAT technique for acute complicated type B aortic dissection. The postoperative course was uneventful, and follow-up computed tomography (CT) showed not only favorable aortic remodeling but also progressive bare metal stent migration in the overlapping zone between the stent graft and the bare metal stent. A 6-month postoperative CT revealed a distal SINE, and the patient underwent re-TEVAR to cover the new entry. Postoperative CT demonstrated successful repair of the distal SINE. The patient is currently in good health 2 years after the reintervention. Conclusion: Surgeons should consider the potential risk of device migration due to favorable aortic remodeling after TEVAR for aortic dissection, especially with the use of additional bare metal stents.