bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Life Difference between Children with Obesity and Children without Obesity
Authors: Tampubolon Nelsi Marintan , Lestari Endang Dewi , Iryawan Andri , Munawaroh Siti 
Published: March 2022

<p><strong><em>ABSTRACT</em></strong></p><p><strong><em>Introduction: </em></strong><em>Obesity has become a global health problem because obesity is widespread in many countries and needs to be addressed immediately. Obesity can happen to anyone, including children and adolescents. Obesity in children can affect physical and mental conditions that can affect the quality of life. This study aims to determine whether there are differences in the quality of life of obese and non-obese children in Warga Junior High School Surakarta</em></p><p><strong><em>Research Methods: </em></strong><em>An analytical observational study with a cross-sectional approach involved 66 students who were divided into 2 groups. Each group consisted of 33 students who were determined by the purposive sampling technique. Weight measurement was carried out to obtain data on obesity status, while the quality of life of students was measured by the Pediatric Quality of Life Inventory (PedsQL) score version 4.0. The data obtained were analyzed by unpaired t-test.</em></p><p><strong><em>Results: </em></strong><em>The obese and non-obese children had a mean PedsQL score of 78,385 and 83,807, respectively. The unpaired t-test in both groups showed a p-value of 0.056.</em></p><p><strong><em>Conclusion: </em></strong><em>The quality of life of obese and non-obese students Warga Junior High School Surakarta was not significantly different.</em><em></em></p><p><strong><em>Keywords: Quality of life; obesity; children; adolescentP</em></strong></p>
Geochemical Evidence and Geological Prerequisites for Isochemical Metamorphism in the Kochumdek Contact Aureole (East Siberia)
Authors: Sokol E.V. , Kozmenko O.A , Deviatiiarova A.S. , Kokh S.N. , Polyansky O.P. , Philippova K.A. 
Published: March 2022

Abstract
—Marly limestone, marble, and gabbro–dolerite samples from the Kochumdek contact aureole are studied in order to estimate to which degree the spurrite–merwinite (T = 750–900 °C) metamorphism at the site was isochemical. The 3 m wide zoned Kochumdek aureole is located at the contact between the Early Triassic trap intrusion of the Kuzmovka complex (νβT1kz) and the overlying Llandovery marine marly limestones (S1ln) of the lower Kochumdek subformation in the right side of the Kochumdek River (tributary of the Podkamennaya Tunguska, East Siberia). The Kochumdek rocks are remarkable by the lack of prominent skarn or vein mineralization in marbles and autometasomatism in gabbro. The samples have been analyzed for major, chalcophile, rare-earth, and high-field strength elements. The Kochumdek marbles and marly limestones share similarity in major-element patterns that record mixing of fine siliciclastic material with biogenic and chemogenic CaCO3 components. The major-element chemistry of marly limestones has been controlled by the compositions of fine clastic material transported from the provenance (Trans-Angara part of the Yenisei Ridge) and by the deposition environment of the early Silurian marine basin. The contents of Cu, Ni, Co, V, Mo, Se, Cr, and U in marly limestones and marbles correspond to marine sediments deposited in a low-productive oxigenated environment. The Ni/Co, V/Cr, Cu/Zn, V/(V+Ni), and U/Th ratios in spurrite marbles at the intrusive contact remain within typical limestone ranges but differ from those in gabbro, which have higher V and Cu enrichment and moderate contents of Zn, Ni, and Co. Marly limestones and spurrite marbles show identical REE+Y patterns and average ΣREE contents. The major- and trace-element similarity between marbles and the protolith limestones, along with the absence of gabbro geochemical signatures in the metamorphic rocks, indicate that the thermal metamorphism was nearly isochemical. The reactions occurred without any large-scale transport of major and trace elements across the sill/sediment boundary. The conditions were unfavorable for metasomatic alteration due to low fluid saturation of the Kochumdek intrusion and its structural setting, as well as to the lithological, mechanical, and thermal properties of the sediments.
Microbial Translocation in Patients with Parkinson’s Disease in Zambia: a Case Control Study
Authors: Chishimba Lorraine , Sinkala Edford , Kelly Paul , Atadzhanov Masharip 
Published: March 2022

Abstract
BACKGROUND Over the past few years evidence has emerged that Parkinson’s disease (PD) could originate from the gastrointestinal tract. Gut leakiness in patients who are genetically susceptible to PD might be an important early component to initiation and progression of the disease, via microbial translocation mechanisms, but this has not been explored in Zambia. OBJECTIVESTo study the association of microbial translocation in patients with Parkinson’s disease (PD) in Zambia.METHODSWe conducted a case control study at the University Teaching Hospital in Lusaka Zambia between October 2019 and March 2020. We enrolled, consecutively 22 PD patients (20 previously diagnosed and 2 newly diagnosed) presenting to the neurology clinic and compared them to 44 unmatched controls from the PD patient household and non-household individuals. We measured plasma lipopolysaccharide binding protein (LBP) levels to assess systemic exposure to gut bacterial endotoxin lipopolysaccharide (LPS) and 16S ribosomal RNA (16S rRNA) gene copy number was quantified by quantitative real-time polymerase chain reaction. RESULTSUsing Fischer’s exact test there was no significant difference in the 16S rRNA gene copy number between the cases and controls (P-value: 0.122). In both groups the levels were very low to undetectable. Lipopolysaccharide binding protein levels were similar in both groups. CONCLUSIONThis data suggests that the markers of microbial translocation, 16S rRNA gene copy number and lipopolysaccharide binding protein levels, in Zambian patients with Parkinson’s disease are similar to those without Parkinson’s disease.
Exploring of phytochemical constituents of Achillea arabica Kotschy. ethanolic flower extract by LC-MS/MS and its possible antioxidant and antidiabetic effects in diabetic rats
Authors: Hanalp Hanife Ceren , Dogan Abdulahad , Saygi Tuba Kusman , Donmez Fatih , Battal Abdulhamit 
Published: March 2022

Abstract
The aim of this study was to reveal the antidiabetic and antioxidant effects of ethanolic lyophilized extract of Achillea arabica flower extract against streptozotosine (STZ)-induced in diabetic rats and to determine its phytochemical content by liquid chromatography with tandem mass spectrometry (LC-MS/MS). After toxicity test, 35 female rats were divided into 5 groups. Control, Diabetes mellitus (DM), A. arabica (400 mg/kg) extract, DM + A. arabica (400 mg/kg) extract and DM + Glibenclamide (2 mg/kg). It was determined that while diabetic rats treated A. arabica plant extract significantly decreased blood glucose level, serum glucose, HbA1c, liver and kidney damage biomarker levels, and malondialdehyde (MDA) content compared to the DM group, it caused fluctuations in antioxidant enzyme levels. According to LC–MS/MS results of A. arabica flower extract, quinic acid (2439.9 μg/g), cyranoside (858.4 μg/g), chlorogenic acid (698.7 μg/g) and cosmosiin (347.8 μg/g) were determined as major compounds, respectively. In addition, two new compounds were determined in this extract according to NMR and Mass analyses and these compounds were named edremitine and achillosine, respectively. Thus, A. arabica flower extract has possible therapeutic effects to prevent high blood glucose level and oxidative stress casued by DM in liver and kidney via its high phenolic content.
Preconception health status of women, 18-45 years, in Trinidad: A cross-sectional study
Authors: Bala Ria , Maharaj Rohan G , Boppana Leela Krishna Teja , Teelucksingh Surujpal 
Published: March 2022

Abstract
BACKGROUND: Despite overwhelming evidence that preconception care (PCC) has the promise to improve the health and welfare of women, infants, and children; it is not routinely undertaken nor recommended to the population of Trinidad and Tobago. This study assessed maternal health status prior to conception by means of a screening tool, physical measurements and laboratory samples in Trinidad.METHODS: A cross-sectional study was conducted among women, aged 18-45, at a primary care centre in Arima, Trinidad, between December 4th 2016 and January 14th 2017. A de novo PCC screening tool assessed 13 domains of high-risk pregnancy in participants. Blood pressure, weight, height and waist circumference were recorded, and a capillary blood sample determined random blood glucose and HbA1c. All data were coded and entered into SPSS ver. 21. RESULTS: A total of 400 women were recruited. 366 were included in the final analysis. Most (96.7%) had one or more risk factors for adverse pregnancy outcomes. These included overweight (BMI ≥ 23) 26.8%, obese (BMI ≥ 27.5) 47.5%, central obesity (WC ≥ 80cm) 69.4%, Impaired Glucose Tolerance/ Diabetes mellitus (IGT/DM) (HbA1C ≥ 5.7) 26.2%, sedentary lifestyle 74.9%, diet high in processed food/fats 88.8%. Only 13.1% had planned to conceive and of those who had no immediate plans of conceiving 76.4% were sexually active and most (60.7%) did not use birth control techniques. More than half (57.1 %) never had a PAP smear. On the other hand, 86.3% knew their HIV status. Self-reporting percentages for vaccination were as follows: 100% had received vaccination for MMR but only 17.5% for tetanus, 11.5% for Hepatitis B and 2.7% for influenza. The vast majority (82.8%) had not visited the dentist in the past year with 35.9% of these exhibiting signs of periodontitis. CONCLUSIONS: The majority of participants had a risk factor for an adverse pregnancy outcome. There is a need for enhanced preconception care for women in Trinidad.
Advanced Water Pollution Control Strategies: A Systematic Review
Authors: Abdallah Clement Kamil , Mourad Khaldoon A. , Cobbina Samuel Jerry 
Published: March 2022

Abstract
A range of technologies, strategies and policies have been implemented to improve water quality worldwide. This systematic review comprehensively appraises technologies, strategies, and water pollution control policies enacted in different countries worldwide between 2055 and 2021. Five databases, Web of Science, PubMed, Scopus, Google scholar and Library of Congress, were used for the search. After screening, a total of 86 eligible manuscripts were selected from 2119 documents for further analysis. Selected articles were divided into two categories: (1) articles introducing the strategies enacted for controlling water pollution based on different technologies, and (2) articles that focused on different policies and regulations to control water pollution in different countries. The results indicated that the most common technologies are Eco-Remediation, Aquatic Vegetation Restoration Technology, Bio-Manipulation Technology, Floating Aquatic-Plant Bed Systems, Wetlands Rehabilitation Technology and Adsorption Technology. And the current one is Atomic Layer Deposition (ALD). Most of these technologies are related to controlling industrial water pollution. Policies and regulations enacted in most countries are pertinent to the industrial and agricultural sectors. Adopting green industrialisation and farming, particularly elimination or limited use of pesticides, was reported as an effective action by governments to reduce water pollution. Overall, most policies enacted by governments can be divided into two general categories: (a) Prescriptive policies (b) Market-Based policies. Depending on the circumstances, these policies are implemented alone or jointly. In addition to the acceptance of international agreements to reduce water pollution by governments, safe agricultural practices, treating industrial waste before discharge play an important role in reducing water pollution.
A novel potent CDK4/6 inhibitor BPI-16350 in preclinical cancer models
Authors: Gao Shuiping , Liu Ru-Jiao , Chen Yang , Wang Yi-qian , Chen Hong , Zhang Hui-juan , Ma Tian-yi , Wang Jia-bing , Hu Xi-Chun , Zhang Jian 
Published: March 2022

Abstract
Inhibition of the cyclin-dependent kinase (CDK) 4/6-retinoblastoma (Rb) pathway is an effective therapeutic strategy against cancer. Here, we report a novel CDK4/6 inhibitor, BPI-16350, identified from comprehensive screening of a large panel of kinases. A series of investigations to evaluate anti-tumor activity show that BPI-16350 exhibits potent antiproliferative activities by inducing G1 arrest in a wide range of human Rb-positive tumor cells. Multiple carcinoma xenografts reveal that BPI-16350 has equivalent or improved anti-tumor efficacy compared with palbociclib or abemaciclib, and achieves obvious tumor regression without body weight loss in experimental animals, where pharmacokinetic study in SD rats indicates a longer half-life of BPI-16350 with once daily. Furthermore, BPI-16350 achieves excellent brain penetration with a nearly sixfold brain-to-plasma ratio in mice, suggesting the potential of treating tumor brain metastasis. Taken together, our findings indicate that BPI-16350 is a novel CDK4/6 inhibitor with favorable pharmaceutical properties as an anti-cancer agent.
­A diagnostic support system based on pain drawings: binary and k-disease classification of EDS, GBS, FSHD, PROMM, and a control group with Pain2D
Authors: Emmert Dorian , Szczypien Natasza , Bender Tim T.A. , Grigull Lorenz , Gass Annette , Link Carolina , Klawonn Frank , Conrad Rupert , Mücke Martin , Sellin Julia 
Published: March 2022

Abstract
Background and objective : The diagnosis of rare diseases (RDs) is often challenging due to their rarity, variability and the high number of individual RDs, resulting in a delay in diagnosis with adverse effects for patients and healthcare systems. The development of computer assisted diagnostic decision support systems (DDSS) could help to improve these problems by supporting differential diagnosis and by prompting physicians to initiate the right diagnostic tests. Towards this end, we developed, trained and tested a machine learning model implemented as part of the software called Pain2D to classify four rare diseases (EDS, GBS, FSHD and PROMM), as well as a control group of unspecific chronic pain, from pen-and-paper pain drawings filled in by patients. Methods: Pain drawings (PDs) were collected from patients suffering from one of the four RDs, or from unspecific chronic pain. The latter PDs were used as an outgroup in order to test how Pain2D handles more common pain causes. A total of 261 (59 EDS, 29 GBS, 35 FSHD, 89 PROMM, 50 unspecific chronic pain) PDs were collected and used to generate disease specific pain profiles (PP). PDs were then classified by Pain2D in a leave-one-out-cross-validation approach. Results: Pain2D was able to classify the four rare diseases with an accuracy of 61-77% with its binary classifier. EDS, GS and FSHD were classified correctly by the Pain2D k-disease classifier with sensitivities between 63-83% and specificities between 83-90%. For PROMM, the k-disease classifier achieved a sensitivity of 51% and specificity of 90%. Conclusions: Pain2D is a scalable, open-source tool that could potentially be trained for all diseases presenting with pain.
Reanalysis of the Revised EEDI Parameters for Inland Ships of Bangladesh
Authors: Hasan S M Rashidul , Karim Md. Mashud 
Published: March 2022

Abstract
A revision of the Energy Efficiency Design Index (EEDI) formulation was previously proposed to be useful for inland ships of Bangladesh. The study had incorporated the shallow water effect using Schlichting’s method, however, the evaluation and presentation of Schlichting’s results did not cover all range of ship parameters. In addition to that, the previous proposal was not based on field studies and the consideration main engine’s Maximum Continuous Rating (MCR) was not appropriate. This study has corrected the previously proposed EEDI formulation for inland ships of Bangladesh based on the physical investigation. In this regard, 15 inland ships of Bangladesh (05 cargo, 05 oil tanker and 05 passenger ships) have been physically investigated. The impact of shallow water effect on EEDI was assessed based on field study, which was compared with approved methods. It was assumed with reasonable considerations that the bank/restricted channel effects on the ship are negligible. The MCR was also fixed based on the field study. It was found that the deviations of Schlichting's results varied from 31.34% to 81.46% in comparison to the investigated results. The deviations of results calculated by Lackenby and Barras methods were varied from 10.10% to 43.83% and -22.19% to 16.53% to the field studies. In addition to that, MCR has been measured for the same 15 ships. Investigated results show that the average MCR for inland cargo and oil tankers of Bangladesh is 70% whereas it is 80% for passenger ships. Based on the key findings of the field studies, a revised EEDI formulation is proposed for the inland ships of Bangladesh.
Ultralong Stretchable Soft Actuator(US2A): Design, Modeling and Application
Authors: wang wenbiao , Zhu Yunfei ,   Shibo1 Cai, Bao Guanjun 
Published: March 2022

Abstract

Actuator plays a significant role in soft robots. This paper proposed an ultralong stretchable soft actuator (US2A) with a variable and sizeable maximum elongation. The US2A is composed of a silicone rubber and a surrounding bellow woven sleeve. The maximal extension can be conveniently regulated by adjusting the wrinkles' initial angle of the bellows woven sleeve. The kinematics of US2A could be obtained by geometrically analyzing the structure of the bellows woven sleeve when the silicone rubber is inflated. Based on the geometrical principle and kinetic energy conservation law, a novel modeling method was developed and used to establish the actuating models: the pressure-elongation model and the force model. These models reflect the influence of the silicone tube's shell thickness and material properties on the pneumatic muscle's performance, which facilitates the optimal design of US2A under different working conditions. The experimental results show that the maximum elongation of the US2A prototype is 257%, and the effective elongation could be variably regulated in range of 0 and 257%. The proposed models were also verified with pressure-elongation and output force-constant pressure experiments, with average error of 5% and 2.5%, respectively. Finally, based on the US2A, we designed a soft arm robot, rigid-soft coupling continuous robot, and pneumatic rehabilitation gloves, which further verified the feasibility of US2A as a soft driving component.
Experimental evaluation of impact factors on VOC emissions from different building materials
Authors: Cheng Zhu , Wang Moxin , Lei Nuoa , Wang Ziyun , Xiong Jie 
Published: March 2022

Abstract

With the continuing urbanization, much public attention has been placed on the pollutant emission of building materials. In this paper, experimental analysis of different emission rate impact factors (including temperature, relative humidity, ventilation, and seasonality) was performed to investigate the characteristic of formaldehyde and TVOC emissions from dry and wet building materials. The experiment was conducted in an environmental chamber, and the effects of the impact factors were analyzed using one-factor-at-a-time control method. The results showed that the VOC emission trends of dry and wet building materials are basically the same over time, so are the emission trend under different air exchange rates. Increased air exchange rate can promote the emission rate, for which the effect of air exchange rate is higher for the TVOC emission rate than for the formaldehyde emission rate. On the other hand, temperature and relative humidity showed significantly higher impacts for the emission rate of formaldehyde than the air exchange rate, and synergy between high temperature and high humidity could increase the emission rate of TVOC. Furthermore, it was found that the formaldehyde emission in the summer is much higher than that in the winter and transition season. In general, results of this research could provide invaluable data support and guidance for TVOC emission control, indoor air pollutants management, and control strategy optimization.
The developement of one-day surgical care in Hungary between 2010-2019
Authors: Ponusz Robert , Endrei Dóra , Kovács Dalma , Pónusz Evelin , Kelemen Bence Kis , Elmer Diána , Németh Noémi , Vereczkei András , Boncz Imre 
Published: March 2022

Abstract
BackgroundThe constant increase in the utilization of one-day surgical care could be identified since more than a decade in most of European countries. Initially, according to the international rankings, the exploitation of one-day surgery in Hungary was not really significant. In 2010, the Hungarian policy makers intended to increase one-day surgical care as a priority strategy. The aim of our study was to analyze the evolution of the Hungarian one-day surgical care during the last decade in DRG- based performance financing system in Hungary.MethodsThe dataset of the research was provided by the National Health Insurance Fund Administration of Hungary. The most important indicators related to the one-day surgical care were compared to inpatient care (market share, number of cases, and DRG cost-weights). To discover the impact of one-day surgical care to the utilization of inpatient treatment, the number of hospitalized days was also analyzed.ResultsBetween 2010-2019, the market share of one-day surgical cases increased from 42%, to 80%. Simultaneously the constant increase of one-day surgical cases, the number of hospitalized days were decreased in inpatient care by 17%. The value of Case Mix Index has also increased, approximately by 140%, which could confirm that more complex interventions are being conducted in one-day surgical care as well. ConclusionsDue to the comprehensive health policy strategy related to the dissemination of one-day surgical care in Hungary, several important performance indicators were improved between 2010-2019. Given that Hungary belongs to the low- and middle-income countries, the results of the study could be considerable even in an international comparison.
Cell-specific regulation of gene expression using splicing-dependent frameshifting.
Authors: Blackshaw Seth , Ling Jonathan , Bygrave Alexei , Santiago Clayton , Carmen-Orozco Rogger , Trinh Vickie , Yu Minzhong , Li Yini , Han Jeong , Taneja Kamil , Liu Ying , Dongmo Rochinelle , Babola Travis , Parker Patrick , Jiang Lizhi , Leavey Patrick , Smith Jennifer , Vistein Rachel , Gimmen Megan , Dubner Benjamin , Teodorescu Patric , arantanos Theodoros K , Ghiaur Gabriel , Kanold Patrick , Bergles Dwight , Langmead Ben , Sun Shuying , Nielsen Kristina , Peachy Neal , Singh Mandeep , Dalton William , Rajaii Fatemeh , Huganir Richard 
Published: March 2022

Abstract
Precise cell-specific gene delivery remains technically challenging. Here we report a splicing-based approach whereby separate translational reading frames are coupled to the inclusion or exclusion of cell-specific alternative exons. Candidate exons are identified by analyzing publicly available RNA sequencing datasets and filtering by cell specificity, sequence conservation, and intron length. This method, which we term splicing-linked expression design (SLED), can be combined in a Boolean manner with existing minipromoters and viral serotypes. We generated AAV-based SLED vectors that selectively target all neurons, photoreceptors, or excitatory neurons. We further used SLED to generate a GluA2 flip/flop reporter and a dual excitatory/inhibitory neuronal calcium indicator. Finally, we show the translational potential of SLED by rescuing photoreceptor degeneration in Prph2rds/rds mice and by developing an oncolytic vector that can selectively induce apoptosis in SF3B1 mutant cancer cells. The flexibility of SLED technology enables new avenues for basic and translational research.