bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trauma Monologue in Beckett’s Krapp’s Last Tape
Authors: He Chu 
Published: October 2022

Abstract
This paper gives a trauma reading of Krapp’s Last Tape. While Krapp’s inability to let go the past and his desolate lifestyle demonstrate a clear symptom of melancholia, he is unable to articulate what exactly has traumatized him nor can he mourn properly for the losses. As a result, he entombs the trauma inside of him and this hidden crypt ghosts him with obsessive or compulsive behaviors. Unaddressed trauma not only withdraws Krapp from life and others but also fragments his self into warring pieces, leaving him suffer endlessly without closure. Through Krapp’s monologue of omission, evasion, and understatement, Beckett has successfully staged a trauma via absence rather than presence.
Venom ophthalmia (keratoconjunctivitis) caused by nuchal gland secretion of Rhabdophis tigrinus: case report
Authors: Matsuura Kazuki , Inoue Yoshitsugu 
Published: October 2022

AbstractRhabdophis tigrinus (R. tigrinus) is a common colubrid snake that possesses a series of paired sac-like nuchal glands behind the head. When pressure is applied to the nuchal area, the thin skin over the nuchal glands can rupture and release secretions. In Japan, 19 cases of ophthalmia caused by the nuchal gland secretion of R. tigrinus have been reported. However, only one case has been documented in an English report. A 72-year old woman was sprayed by the nuchal gland fluid of R. tigrinus in her right eye. She presented with symptoms of eye pain and blurred vision. A slit-lamp examination revealed diffuse superficial keratitis, corneal stromal edema with Descemet membrane folds, and conjunctival injection. The best-corrected visual acuity (BCVA) of her right eye was 0.6. She was prescribed 0.5% moxifloxacin and 0.1% fluorometholone eye drops four times a day, and the symptoms resolved without sequelae within 5 days. The BCVA in the right eye improved to 1.0. In previous reports, ophthalmic examinations revealed conjunctivitis, keratitis, and corneal edema with Descemet membrane folds. Topical antibiotics and corticosteroid were prescribed in most cases, and eyes healed within 5-7 days without any sequelae. While corneal edema may resolve spontaneously in a few days when inhibition of the toxin has ceased, the use of topical steroids is recommended, as it can increase the activity of Na/K pumps that remained functional, thereby accelerating recovery. In fact, our patient used a topical steroid and recovered without sequelae.
Network analysis for estimating standardization trends in genomics using MEDLINE
Authors: Bae Eun Bit , Nam Sejin , Lee Sungin , Ahn Sun-Ju 
Published: October 2022

Abstract
Background
Biotechnology in genomics, such as sequencing devices and gene quantification software, has proliferated and been applied to clinical settings. However, the lack of standards applicable to it poses practical problems in interoperability and reusability of the technology across various application domains. This study aims to visualize and identify the standard trends in clinical genomics and to suggest areas on which standardization efforts must focus.

Methods
Of 16,538 articles retrieved from PubMed, published from 1975 to 2020, using search keywords “genomics and standard” and “clinical genomic sequence and standard”, terms were extracted from the abstracts and titles of 15,855 articles. Our analysis includes (1) network analysis of full phases (2) period analysis with five phases; (3) statistical analysis; (4) content analysis.

Results
Our research trend showed an increasing trend from 2003, years marked by the completion of the human genome project (2003). The content analysis showed that keywords related to such concepts as gene types for analysis, and analysis techniques were increased in phase 3 when US-FDA first approved the next-generation sequencer. During 2017–2019, oncology-relevant terms were clustered and contributed to the increasing trend in phase 4 of the content analysis. In the statistical analysis, all the categories showed high regression values (R2 > 0.586) throughout the whole analysis period and phase-based statistical analysis showed significance only in the Genetics terminology category (P = .039*) at phase 4.

Conclusions
Through comprehensive trend analysis from our study, we provided the trend shifts and high-demand items in standardization for clinical genetics.
A non-randomised feasibility study of the Rehabilitation Potential Assessment Tool (RePAT) in frail older people in the acute healthcare setting
Authors: Cowley Alison , Goldberg Sarah E. , Gordon Adam L. , Logan Pip A. 
Published: October 2022

Abstract
Background
Rehabilitation potential involves predicting who will benefit from rehabilitation. Decisions about rehabilitation potential must take into account personal, clinical and contextual factors, a process which is complicated in the presence of acute ill-health and frailty. This study aimed to evaluate the feasibility and acceptability of the Rehabilitation Potential Assessment Tool (RePAT) – a 15 item holistic, person-centred assessment tool and training package – in the acute hospital setting.

Methods
A non-randomised feasibility study with nested semi-structured interviews explored whether RePAT was feasible and acceptable. Feasibility was tested by recruiting physiotherapy and occupational therapy participants delivering the RePAT intervention to patients alongside usual clinical care. Acceptability was tested by conducting semi-structured interviews with staff, patient and carer participants. Staff and patient characteristics were analysed using descriptive statistics. Interview data were analysed thematically. Fidelity of completed RePAT items was assessed against a priori criteria on how closely they matched tool guidance by two researchers. Mean values of the two scores were calculated. RePAT content was analysed and supported with verbatim quotes.

Results
Six staff participants were recruited and trained. They assessed 26 patient participants using RePAT. Mean (SD) patient age was 86.16 (±6.39) years. 32% were vulnerable or mildly frail, 42% moderately frail and 26% severely or very severely frail using the Clinical Frailty Scale. Mean (SD) time to complete RePAT was 32.7 (±9.6) minutes. RePAT fidelity was good where 13 out of 15 items achieved a priori fidelity. RePAT was acceptable and tolerated by staff and patients. Staff participants reported RePAT enabled them to consider rehabilitation decisions in a more structured and consistent way. Patients and carer participants, although unable to comment directly on RePAT, reported being satisfied with their rehabilitation assessments which were found to embrace a person-centred approach.

Conclusions
RePAT was found to be acceptable and feasible by staff, carers and patients. It allowed clinicians to make explicit their reasoning behind rehabilitation assessments and encouraged them to become more cognisant of factors which affected their clinical decision-making.

Trial registration
ID ISRCTN31938453. Registered 05/10/2021.
Infant behavioral state and stool microbiome in infants receiving Lactocaseibacillus rhamnosus GG in formula: randomized controlled trial
Authors: Shulman Robert J. , Chichlowski Maciej , Orozco Fabiola Gutierrez , Harris Cheryl L. , Wampler Jennifer L. , Bokulich Nicholas A. , Berseth Carol Lynn 
Published: October 2022

Abstract
Background
Our aim was to evaluate infant behavioral state, stool microbiome profile and calprotectin in infants with infantile colic receiving a partially hydrolyzed protein formula with or without added Lacticaseibacillus (formerly Lactobacillus) rhamnosus GG (LGG).

Methods
In this single-center, double-blind, controlled, parallel, prospective study, term infants (14–28 days of age) identified with colic (using modified Wessel’s criteria: cried and/or fussed ≥ 3 h/day for ≥ 3 days/week, in a one-week period) were randomized to receive one of two formulas over a three-week feeding period: marketed partially hydrolyzed cow’s milk-based infant formula (PHF, n = 35) or a similar formula with added LGG (PHF-LGG, n = 36). Parent-reported infant behavior was recorded at three time points (Study Days 2–4, 10–12, and 18–20). Duration (hours/day) of crying/fussing (averaged over each three-day period) was the primary outcome. Stool samples were collected at Baseline and Study End (Days 19–21) to determine stool LGG colonization (by qPCR) and microbial abundance (using 16S rRNA gene sequencing) and calprotectin (μg/g).

Results
Duration of crying/fussing (mean ± SE) decreased and awake/content behavior increased over time with no significant group differences over the course of the study. There were no group differences in the percentage of infants who experienced colic by study end. Colic decreased by Study End vs Baseline in both groups. Change in fecal calprotectin also was similar between groups. Comparing Study End vs Baseline, LGG abundance was greater in the PHF-LGG group (P < 0.001) whereas alpha diversity was greater in the PHF group (P = 0.022). Beta diversity was significantly different between PHF and PHF-LGG at Study End (P = 0.05). By study end, relative abundance of L. rhamnosus was higher in the PHF-LGG vs PHF group and vs Baseline.

Conclusions
In this pilot study of infants with colic, both study formulas were well tolerated. Crying/fussing decreased and awake/content behavior increased in both study groups over the course of the study. Study results demonstrate a successful introduction of the probiotic to the microbiome. The partially hydrolyzed protein formula with added LGG was associated with significant changes in the gut microbiome.

Trial registration
ClinicalTrials.gov, ClinicalTrials.gov Identifier: NCT02340143. Registered 16/01/2015.
LINC00467: an oncogenic long noncoding RNA
Authors: Chen Xuyu , Luo Qian , Xiao Yanan , Zhu Jing , Zhang Yirao , Ding Jie , Li Juan 
Published: October 2022

AbstractLong non-coding RNAs (lncRNAs) have been found to play essential roles in the cell proliferation, fission and differentiation, involving various processes in humans. Recently, there is more and more interest in exploring the relationship between lncRNAs and tumors. Many latest evidences revealed that LINC00467, an oncogenic lncRNA, is highly expressed in lung cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma, breast cancer, glioblastoma, head and neck squamous cell carcinoma, osteosarcoma, and other malignant tumors. Besides, LINC00467 expression was linked with proliferation, migration, invasion and apoptosis via the regulation of target genes and multiple potential pathways. We reviewed the existing data on the expression, downstream targets, molecular mechanisms, functions, relevant signaling pathways, and clinical implications of LINC00467 in various cancers. LINC00467 may serve as a novel biomarker or therapeutic target for the diagnosis and prognosis of various human tumors.
Aquatic Board Sport Injuries: A Literature Review
Authors: Hasenkamp Eric , McGahee Jonathan , Richter Madeline , Lu Myro 
Published: October 2022

Abstract
Aquatic board sports, particularly traditional surfing, kitesurfing, skimboarding, stand-up paddleboarding, and foil surfing, are growing in popularity. Increased participation has revealed similar injury types, mechanisms, and unique patterns related to the individual board sports. Practitioners who live near aquatic environments should familiarize themselves with these injury patterns to provide high-quality care and prevention for participating individuals. This article will examine the current literature for each aquatic board sport and summarize specific injury-type data to provide better guidance to clinicians.
Sports Medicine Health Care Access in Michigan High Schools: Access to Athletic Trainers
Authors: Moeller James L. , Ciecko John 
Published: October 2022

Abstract
Disparities in access to health care services may lead to poor health outcomes. Health care encounters in the adolescent age group are often due to sport participation. The presence of an athletic trainer in high schools can improve health outcomes in adolescent athletes, but not all student-athletes have access to an athletic trainer. In the state of Michigan, many high schools do not provide athletic trainer access to their student athletes. Our aim was to determine factors associated with the presence or absence of athletic trainer access in Michigan high schools. Disparities are associated with student body population, student-athlete population, and average household income in the zip code in which the school is located.
Double Guardianship and Hellenistic Monarchy: Protecting the Person of Infant Kings
Authors: Filias Dionysios 
Published: October 2022

This article aims to present the institution of double guardianship of infant kings by pointing to the connection between appointment of more than one guardian and protection and upbringing of young monarchs. Multiple guardianship was an established practice in the setting of Greek poleis, which aimed at the protection of the ward’s person from untrustworthy guardians. In a royal context this institution emerged as a solution to the problems concerning Alexander’s succession after 323 BC. Nevertheless, there is a possibility that it was already known in Classical Macedonia in relation to the role of royal women, who acted as protectors of their children along with men who were appointed as regents. During the Hellenistic era double guardianship became very popular in the Ptolemaic kingdom. There it is connected with the loss of the queen mother, who could exercise guardianship for her royal son. Tutorship and guardianship were sometimes combined into one person, something that led influential tutors of young rulers to become the true administrators of the kingdom.
Ἔθνη Θρᾳκῶν στὴ Θράκη τοῦ Αἰγαίου κατὰ τοὺς ἑλληνιστικοὺς καὶ ρωμαϊκοὺς χρόνους I. Κορπίλοι καὶ Κορπιλική
Authors: Παρισάκη Μαρία-Γαβριέλλα 
Published: October 2022

Of two articles devoted to the Thracian tribes attested in Aegean Thrace during the Hellenistic and Roman periods, the first, published here, focuses on the tribe of the Corpiloi (the second article, under the title ‘Ἔθνη Θρᾳκῶν στὴ Θράκη τοῦ Αἰγαίου κατὰ τοὺς ἑλληνιστικοὺς καὶ ρωμαϊκοὺς χρόνους, ΙΙ. Σαπαῖοι καὶ Σαπαϊκή’, devoted to the Sapaioi, will be published in the following volume of Τεκμήρια). The relevant testimonia, exclusively literary, range from the first century BC ‒or the beginning of the second century BC, for those who accept the emendation Coreli-Corpili in the text of Livy‒ to the beginning of the second century AD. They consist of short references in Strabo, Pliny the Elder, and Solinus, a reference to the στενὰ τῶν Κορπίλων by Appian in conjunction with the battle of Philippi in 42 BC, as well as a reference to a Κορπιλικὴ στρατηγία in Claudius Ptolemy. The present article tries to define Corpiloi’s localization, suggesting the lower course of the Hebrus river, mainly to the west but also, possibly, to the east of the river, up to the north of Ainos. In view of their relatively short emergence in ancient sources, the article also addresses the question of Corpiloi’s relation to the region’s major tribes, namely the Odrysai and the Sapaioi. Finally, a brief and preliminary overview of the region’s archaeological map indicates integration into the region’s wider cultural sphere.
A community-led project in Kwekwe, Zimbabwe: implementing self-care and respectful maternity care
Authors: Mudokwenyu-Rawdon Christina , Maposhere Caroline , Mahere Gretel , Goshomi Unice 
Published: October 2022

Background Most (90%) maternal deaths occur in sub-Saharan Africa and south Asia. Self-care and respectful maternity care strategies are effective in reducing maternal and newborn mortality and morbidity. This article discusses a community-led project to train members of the community in self-care and respectful maternity care. This project aimed to contribute to the reduction of maternal and newborn deaths in Kwekwe, Zimbabwe. Methods Using a six-phase approach, 51 women and their families were trained in birth preparedness, complication prevention and readiness and respectful maternity care practices. Quantitative and qualitative data were collected before and after implementation of the training project using a checklist for quantitative data and guided in-depth interviews via focus group discussions and face-to-face interviews with the district nursing officer, two in-charges and two chairmen of the health centre committees. Comparative descriptive analysis and qualitative content analyses for the two sets of data was done for impact evaluation. Results Since the inception of self-care and respectful maternity care practice standards (January–December 2017) in the project sites, there have been no maternal deaths, compared to four maternal deaths in the previous year (January–December 2016). Antenatal care bookings within the first 12 weeks of pregnancy increased from 3−5 to 28 per month by the end of the project. Conclusions A reduction in maternal and neonatal deaths can be realised when a community of practice and a self-care and respectful maternity care model are supported by a well-equipped healthcare system.
Home birth prevalence and associated factors in southwest Ethiopia
Authors: Legese Tegene , Sileshi Samrawit , Daniel Abeba , Nigusie Tadesse , Henok Andualem , Bekele Yordanos , Negash Samuel , Mekonen Besufekad , Solomon Nahom , Kassie Aychew , Asmare Wondwossen Niguse 
Published: October 2022

Background/Aim In Ethiopia, antenatal care takes a focused approach, where women are encouraged to give birth in a health facility, as there are no services that provide skilled birth attendants for home births. However, nearly half of mothers booked for antenatal care give birth at home, which is associated with a higher risk of maternal mortality and poor outcomes. This study aimed to assess the prevalence of home birth and associated factors among women in southwest Ethiopia. Methods A community-based cross-sectional study was conducted using simple random sampling. Data were collected from 1 February 2018 to 30 April 2018 from 1831 women who had given birth in the last year in selected zones of southwest Ethiopia, using a structured interviewer-administered questionnaire. The data were cleaned and exported to STATA 14 for analysis, both by bivariate and multivariate logistic regression. P≤ 0.05 at 95% confidence interval of odds ratio was taken as significant in the multivariable model. Results Approximately half (54.5%) of the participants gave birth at home. Rural residence (adjusted odds ratio=0.46, P=0.032), listening to the radio (adjusted odds ratio=0.53, P=0.047), attending 3–5 antenatal care visits (adjusted odds ratio=0.40, P=0.031), being widowed or divorced (adjusted odds ratio=2.89, P=0.045), prolonged labour (adjusted odds ratio=0.76, P=0.021) and waiting time for antenatal care services (adjusted odds ratio=1.85, P=0.042) were significantly associated with home birth. Conclusions More than half of the participants gave birth to their last child at home, and this decision was affected by residence, prolonged labour, antenatal care frequency, media, marital status, and waiting time for antenatal care services. Interventions to increase institutional birth should prioritise those who do not attend antenatal care, are not exposed to media or who are widowed or divorced. Similarly, reducing antenatal care waiting time and encouraging mothers to attend antenatal care are vital to improving rates of institutional birth in Ethiopia.
Perinatal outcomes and maternal complications at a county referral hospital in Kenya
Authors: Mulwa Joseph Kithokoo , Makworo Drusilla , Githinji Mwangi Elijah 
Published: October 2022

Introduction/Aims Maternal complications during pregnancy and labour are a leading cause of global maternal and neonatal mortality. Despite efforts by the Kenyan Government, the mortality rate in the country is now 22 neonatal deaths per 1000 live births. This study's aims were to observe and compare perinatal outcomes of newborns from women with and without maternal complications. Methods This was a prospective hospital-based paired cohort study of 510 pregnant women, 102 of whom presented with complications. Follow up took place up to 28 days after birth, at which point 132 women with complications and 364 women without complications completed the study (some women developed complications after initial recruitment and crossed over to the complications group). Data were gathered on obstetric characteristics and perinatal outcomes using a structured, researcher-administered questionnaire. Differences between the two groups (with and without complications) in terms of obstetric data were compared using Pearson's Chi-squared test. Associations between complications and obstetric characteristics were tested using relative risk. Results Almost all obstetric characteristics showed significant differences between groups, with the exception of a history of poor obstetric outcomes and known contracted pelvis. A mother with complications was more likely to have a newborn with a low Apgar score (relative risk 8.000, P<0.001), low birth weight (relative risk: 1.838, P<0.001), prematurity (relative risk 9.652, P<0.001), admission to the newborn unit (relative risk 8.000, P<0.001), complications after 28 days (relative risk: 2.186, P=0.017) and admission after 28 days (relative risk: 4.892, P=0.006). Mothers with complications were also more likely to have given birth by caesarean section (relative risk: 13.893, P<0.001). Conclusions The newborns born to women who experienced maternal complications were at a higher risk of poor perinatal outcomes compared to those born to women without maternal complications at the Kitui County Referral Hospital. Newborn care should be scaled up to deal with the most difficult cases brought about by maternal complications. Rural facilities should be well equipped to be able to deal with poor outcomes in newborns.
Factors contributing to home births among postpartum women in Manzini, Swaziland
Authors: Msibi Zethu Sandrah , Ntsoele Monica Motsegoane Naomi , Phaladi-Digamela Rebecca Mauwane 
Published: October 2022

Background/Aims Home births carry risks, especially in underdeveloped areas, including labour and childbirth complications and maternal and perinatal morbidity and mortality. Intrapartum care offered in healthcare facilities has fewer risks, as they employ skilled birth attendants and medical equipment. However, widespread provision of intrapartum care remains challenging in Swaziland. The incidence of avoidable intrapartum maternal and perinatal challenges could be reduced if more women gave birth accompanied by skilled birth attendants. The aim of this study was to explore and describe the factors associated with home birth in Swaziland, despite the practice being discouraged. Methods A qualitative design using convenient sampling was used. A total of 13 postpartum women took part in the study, who gave birth at home and brought their newborn babies to a well-baby clinic for immunisation 3 days after birth. Individual in-depth interviews were conducted and the data were subjected to thematic analysis. One theme was identified with associated subthemes. Results Personal factors formed the main theme describing the reasons for home birth. The subthemes were ignorance, silent labour, financial problems and access to a traditional birth attendant. Conclusions Enhanced health education during antenatal care on labour signs as well as reduced or abolished hospital fees for pregnant women and improved availability of ambulance services may help address women's reasons for choosing home birth. Encouraging women to give birth with a skilled birth attendant is important to reduce maternal and neonatal morbidity and mortality.