bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rare case of pituicytoma-related hypercortisolism in a patient with Cushing syndrome—case report
Authors: Amoateng Magdelene , Ibrahim Eiman , Ahmad Yasir , Calikyan Anoush , Hulinsky Ilja 
Published: July 2022

Abstract
Background
Distinguishing between a pituitary adenoma and a pituicytoma can be challenging. Hormonal changes in pituicytomas are uncommon, and the tumor's mass effect has triggered most symptoms. There were only two reported cases of pituicytoma with elevated hormonal levels in patients who presented with Cushing syndrome as of 2017.

Case presentation
This report describes a rare case of a patient who had Cushing syndrome from a pituitary-related hypercortisolism, most likely a pituicytoma with neuroendocrine features with the benefit of early detection and surgical resection.

Conclusions
Pituicytomas have malignant tendencies while pituitary adenomas are mostly benign, hence the need to distinguish them accurately for prompt treatment and improved prognosis.
The influence of age and weight on the outcomes of complete atrioventricular septal defect repair
Authors: Al-Wassia Heidi K. , Al-Radi Osman O. , Maghrabi Khadijah A. , Bayazeed Mawadda A. , Qattan Murooj M. , Ebraheem Doaa T. , Gadi Sarah U. , Kattan Mernan F. , Alghamdi Reema A. , Alzabidi Samaher H. , Dohain Ahmed M. 
Published: July 2022

Abstract
Background
The appropriate age and weight for surgical repair of atrioventricular septal defect (AVSD) is an area of controversy. We aimed to study the effect of weight and age at the time of surgical repair for complete AVSD in children less than 2 years of age on postoperative outcomes. A retrospective data review was performed for patients who underwent the AVSD repair from 2012 to 2019 at our institutions. Our primary outcome was the postoperative in-hospital length of stay (LOS). Secondary outcomes included total positive pressure ventilation (PPV), ventilation time, maximum vasoactive–inotropic score (max VIS), and other postoperative complications.

Results
The study included fifty patients. The median age was 191 days, and the median weight was 4.38 kg at the time of surgery. Weight < 4 kg was associated with longer PPV time and postoperative in-hospital LOS (p value of 0.033 and 0.015, respectively). Additionally, they had higher max VIS at 24 h and 48 h than the other groups with bodyweight 4–5.9 kg or ≥ 6 kg (p value of 0.05 and 0.027, respectively). Patients with older age or lower weight at operation had a longer in-hospital LOS and total length of PPV after surgery. There were no postoperative in-hospital deaths.

Conclusions
Older age and lower weight at the time of surgical repair of atrioventricular septal defect could be independent predictors of prolonged postoperative in-hospital length of stay and total length of positive pressure ventilation.
Effect of perceived risk, challenges, and coping on anxiety and depression among frontline health workers during the COVID-19 pandemic in Bangladesh
Authors: Karim Md Rizwanul , Ahmed Helal Uddin , Shaoli Salowa Salam 
Published: July 2022

Background: During the COVID-19 pandemic the health care workers (HCWs) encountered one of the heaviest blows by saving lives while endangering their own. This study was carried out to investigate risk exposures, risk perceptions, challenges, and coping strategies, leading to anxiety and depression, among HCWs in Bangladesh. Methods: This hospital-based cross-sectional survey was conducted from February to July 2021 among 1,112 frontline HCWs. Data were collected using a pre-tested self-administered questionnaire including Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder (GAD-7) scale. A coping scale for COVID-19 (CS-COV-19) was developed and validated. To determine the predictors for symptoms of depression and anxiety, multivariable logistic regression analysis was performed, and the associations between key variables are presented as odds ratios (ORs) and 95% CIs. Results: A total of 54.9% (n=389) doctors and 51.4% (n= 207) nurses were found to have mild to severe anxiety status and 47% (n=333) doctors and 39.9% (n= 159) nurses were found to have mild to severe depression. HCWs, family members, neighbors had been affected with COVID-19 and those who experienced extra stresses at work were two times more likely to have anxiety. HCWs who had worried family and friends that they might get infected through them, confronted any negative social attitude or perceptions, decreased monthly income, and depression were 1.57 to 1.8 times more likely to experience anxiety than those who did not go through these experiences. Health workers who confronted negative social attitudes or social perceptions were 1.7 times more likely to have depression. Respondents, who had family members infected with COVID-19 and HCWs who worked for long hours at hospitals were almost two times more likely to have depression. Conclusions: The findings will help promoting advocacy and encourage implementing selective interventions to protect the mental health and wellbeing of HCWs working with COVID-19.
Use of lasers in hidradenitis suppurativa treatment – case report
Authors: Kozinska Urszula , Gras-Ozimek Jordi , Kozińska Iga 
Published: July 2022

Acne inverse sometimes known as hidradenitis suppurativa is a long-term dermatological condition. Due to the poorly examined nature of the disease the effectiveness of its treatments is unclear. More than 50 interventions have been described and therefore its diagnostic and the treatment can be challenging. The aim of this case report is to draw attention to the possible use of laser therapy in the treatment of hidradenitis suppurativa.
A case report.
We report the case of 27-year-old woman that has been successfully treated with laser after years of an ineffective treatment. Due to the failure of systemic and local antibiotic therapy, hormone therapy, surgical drainage and orally and externally applied retinoids, removal of lesions using a CO2 laser knife and a fractional laser therapy combining a CO2 laser and a 1570 nm wavelength laser on the surface of the affected skin was performed.
Conclusions.
The use of laser therapy, with particular emphasis on the CO2 laser, may be an important and effective element of hidradenitis suppurativa treatment.
Forecast Selection and Representativeness
Authors: Petropoulos Fotios , Siemsen Enno 
Published: July 2022

Effective approaches to forecast model selection are crucial to improve forecast accuracy and to facilitate the use of forecasts for decision-making processes. Information criteria or cross-validation are common approaches of forecast model selection. Both methods compare forecasts with the respective actual realizations. However, no existing selection method assesses out-of-sample forecasts before the actual values become available—a technique used in human judgment in this context. Research in judgmental model selection emphasizes that human judgment can be superior to statistical selection procedures in evaluating the quality of forecasting models. We, therefore, propose a new way of statistical model selection based on these insights from human judgment. Our approach relies on an asynchronous comparison of forecasts and actual values, allowing for an ex ante evaluation of forecasts via representativeness. We test this criterion on numerous time series. Results from our analyses provide evidence that forecast performance can be improved when models are selected based on their representativeness. This paper was accepted by Manel Baucells, behavioral economics and decision analysis. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2022.4485 .
Supplementary information for "Water Productivity of Irrigated Tomatoes in Eastern Canada Based on AquaCrop Simulations"
Authors: Arumugagounder Thangaraju Naresh Kumar , Ihuoma Samuel , Madramootoo Chandra 
Published: July 2022

<p>The table presents the AquaCrop input dataset classified based on the source of input and the figure displays the seasonal crop Kc values obtained from the AquaCrop simulation for the tomato. </p>
High-performance subwavelength polarizer using “sandwich” structured substrates
Authors: Zhao Jiangting , Zhao Donghua , Liu Wancheng , Cao Huiliang , Wang Chenguang , Tang Jun , Shen Chong , Liu Jun 
Published: July 2022

A subwavelength polarizer based on “sandwich” structured substrates is proposed in this study. The proposed subwavelength polarizer consists of three layers of subwavelength aluminum wires and dielectric substrate. The designed structure achieves an extinction ratio (ER) greater than 90 dB in a 400–800 nm visible wavelength region, achieving a maximum ER of 135 dB at 750 nm. Our results demonstrate significant improvements over the conventional single- and double-grid polarizers in terms of an ER and spectral range coverage. The proposed subwavelength polarizer in this paper has great potential in polarimetric imaging, liquid crystal display, and other optical fields.
SARS-CoV-2 seropositivity and COVID-19 among 5 years-old Amazonian children and their association with poverty and food insecurity
Authors: Ferreira Marcelo U. , Giacomini Isabel , Sato Priscila M. , Lourenço Barbara H. , Nicolete Vanessa C. , Buss Lewis F. , Matijasevich Alicia , Castro Marcia C. , Cardoso Marly A. ,   for the MINA-Brazil Working Group
Published: July 2022

Background
The epidemiology of childhood SARS-CoV-2 infection and COVID-19-related illness remains little studied in high-transmission tropical settings, partly due to the less severe clinical manifestations typically developed by children and the limited availability of diagnostic tests. To address this knowledge gap, we investigate the prevalence and predictors of SARS-CoV-2 infection (either symptomatic or not) and disease in 5 years-old Amazonian children.

Methodology/Principal findings
We retrospectively estimated SARS-CoV-2 attack rates and the proportion of infections leading to COVID-19-related illness among 660 participants in a population-based birth cohort study in the Juruá Valley, Amazonian Brazil. Children were physically examined, tested for SARS-CoV-2 IgG and IgM antibodies, and had a comprehensive health questionnaire administered during a follow-up visit at the age of 5 years carried out in January or June-July 2021. We found serological evidence of past SARS-CoV-2 infection in 297 (45.0%; 95% confidence interval [CI], 41.2–48.9%) of 660 cohort participants, but only 15 (5.1%; 95% CI, 2.9–8.2%) seropositive children had a prior medical diagnosis of COVID-19 reported by their mothers or guardians. The period prevalence of clinically apparent COVID-19, defined as the presence of specific antibodies plus one or more clinical symptoms suggestive of COVID-19 (cough, shortness of breath, and loss of taste or smell) reported by their mothers or guardians since the pandemic onset, was estimated at 7.3% (95% CI, 5.4–9.5%). Importantly, children from the poorest households and those with less educated mothers were significantly more likely to be seropositive, after controlling for potential confounders by mixed-effects multiple Poisson regression analysis. Likewise, the period prevalence of COVID-19 was 1.8-fold (95%, CI 1.2–2.6-fold) higher among cohort participants exposed to food insecurity and 3.0-fold (95% CI, 2.8–3.5-fold) higher among those born to non-White mothers. Finally, children exposed to household and family contacts who had COVID-19 were at an increased risk of being SARS-CoV-2 seropositive and–even more markedly–of having had clinically apparent COVID-19 by the age of 5 years.

Conclusions/Significance
Childhood SARS-CoV-2 infection and COVID-19-associated illness are substantially underdiagnosed and underreported in the Amazon. Children in the most socioeconomically vulnerable households are disproportionately affected by SARS-CoV-2 infection and disease.
Transitions and challenges for people with Parkinson’s and their family members: A qualitative study
Authors: Read Joy , Frost Rachael , Walters Kate , Tuijt Remco , Manthorpe Jill , Maydon Bev , Pigott Jennifer , Schrag Anette , Davies Nathan 
Published: July 2022

Objective
To explore the experiences and challenges of people with Parkinson’s and their family members living in the community through the lens of their transitions to better understand the phases and changes in their lives.

Design
Qualitative study using semi-structured interviews and analysed using codebook thematic analysis.

Setting/participants
Purposive sampling was used in primary and secondary healthcare services across Southern England in 2019 to recruit 21 people with Parkinson’s (aged between 45–89 years) and 17 family members (13 spouses and 4 adult children, aged between 26–79 years).

Results
Participants’ descriptions were classified in three main phases of transition from a place of health towards greater dependency on others: 1) ‘Being told you are a person with Parkinson’s’ (early), 2) ‘Living with Parkinson’s’ (mid), and 3) ‘Increasing dependency’ (decline). Seven sub-themes were identified to describe the transitions within these three phases: phase 1: receiving and accepting a diagnosis; navigating reactions; phase 2: changing social interactions and maintaining sense of self; information: wanting to know but not wanting to know; finding a place within the healthcare system; and 3: changes in roles and relationships; and increasingly dependent.

Conclusion
This study has identified points of change and means of supporting key transitions such as diagnosis, changes in social connections, and increased use of secondary healthcare services so that comprehensive, holistic, individualised and well-timed support can be put in place to maintain well-being.
Frequent detection of functional hyposplenism via assessment of pitted erythrocytes in patients with advanced liver cirrhosis
Authors: Wehmeyer Malte H. , Sekhri Harsha , Wroblewski Raluca , Galante Antonio , Meyer Thomas , Lohse Ansgar W. , Schulze zur Wiesch Julian 
Published: July 2022

Background
Asplenia or functional hyposplenism are risk factors for severe infections, and vaccinations against encapsulated bacteria are advised. There are only limited data regarding the spleen function of cirrhotic patients.

Methods
We evaluated spleen function in patients with liver cirrhosis, who were prospectively enrolled in this study. Spleen function was evaluated by the measurement of pitted erythrocytes. Functional hyposplenism was defined as a percentage of PE of >15%.

Results
117 patients, mean age 58.4 years and 61.5% (n = 72) male with liver cirrhosis were included. Functional hyposplenism was diagnosed in 28/117 patients (23.9%). Pitted erythrocytes correlated with albumin (p = 0.024), bilirubin (p<0.001), international normalized ratio (INR; p = 0.004), model of end-stage liver disease (MELD) score (p<0.001) and liver stiffness (p = 0.011). Patients with functional hyposplenism had higher MELD scores (median 13 vs. 10; p = 0.021), liver stiffness (46.4 kPa vs. 26.3 kPa; p = 0.011), INR (1.3 vs. 1.2; p = 0.008) and a higher Child-Pugh stage (Child C in 32.1% vs. 11.2%; p = 0.019) as compared to patients without functional hyposplenism. Functional hyposplenism was not associated with the etiology of cirrhosis. Importantly, 9/19 patients with Child C cirrhosis had functional hyposplenism.

Conclusion
A quarter of patients with liver cirrhosis and almost 50% of patients with Child C cirrhosis have functional hyposplenism. Functional hyposplenism is associated with poor liver function and the degree of portal hypertension, which is characterized by higher liver stiffness measurements in transient elastography.
Practices of herbal management of malaria among trading mothers in Shai Osudoku District, Accra
Authors: Appiah Evans Osei , Appiah Stella , Oti-Boadi Ezekiel , Oppong-Besse Albert , Awuah Dorothy Baffour , Asiedu Priscilla Ofosuhemaa , Oti-Boateng Lt Emmanuel 
Published: July 2022

Background
Malaria is one of the leading causes of morbidity in the world. It is a significant health concern in most developing countries, including Ghana. Even though there are several orthodox medications used for decades in treating malaria effectively, a substantial number of individuals in developing countries are resorting to the use of herbs in the treatment of malaria. The study aim at exploring the practices of herbal management of malaria among trading mothers in Shai Osudoku District, Accra.

Methods
A qualitative approach with an exploratory, descriptive design was adopted in analyzing the research problem. Purposive sampling technique was used to select twenty (20) participants to partake in a face-face interview, guided by a semi-structured interview guide. The data were transcribed verbatim and analysed by adopting content analysis.

Results
Two significant themes and seven subthemes were generated following the analysis of this study. The main themes were; preferences for herbal malaria treatment and the practices and effectiveness of herbal medicine used for malaria treatment. It was worth noting that the women’s cultural beliefs did not influence their preference for herbal malaria treatment. The main challenge associated with the herbal malaria treatment was inappropriate dosage specification.

Conclusion
This study discovered that several factors influenced participants’ preferences for malaria treatment. Participants further listed some traditional ways of treating malaria which implies that there is herbal malaria practice. However, literature in this area is inadequate, and most herbs lack specifications for use. It is therefore recommended that future research focus on scientific herbal malaria treatment. Also, regulating bodies should ensure that quality herbal drugs are sold for consumption.
Risk factors of necrotizing enterocolitis-related mortality in preterm neonates: a preliminary prospective study
Authors: Kaban Risma Karina , Rohsiswatmo Rinawati , Kautsar Ahmad , Sutrisno Audesia Alvianita , Hikmahrachim Hardya Gustada , Hardiyanti Nieta 
Published: July 2022

Background Necrotizing enterocolitis (NEC) is a prematurity-related complication of the gastrointestinal tract that affects 3-15% of preterm infants. Due to its atypical signs and symptoms, NEC is often diagnosed late, leading to mortality and morbidity.
Objective To describe the incidence, characteristics, and survival rate of preterm infants with NEC in the Neonatal Unit of Cipto Mangunkusumo Hospital.
Methods This prospective cohort study was conducted on preterm infants born in Cipto Mangunkusumo Hospital in 2019 who had NEC Bell stage 2 or higher. Subjects were recruited consecutively. NEC was classified into either early-onset (<14 days of life) or late-onset (?14 days of life). We identified the risk factors of mortality and survival using multiple Cox regression.
Results Within the study period, 55/639 preterm infants born in Cipto Mangunkusumo Hospital were diagnosed with NEC. Mean gestational age was 31.16 (SD 2.63) weeks and mean birth weight was 1,378.12 (SD 438.26) grams. The median age at NEC diagnosis was 6 (range 0-24) days. The most common symptoms were gastrointestinal bleeding (29.09%) and abdominal distension (29.09%). Plain abdominal radiographs showed dilated bowels in 92.72%, thickened intestinal walls in 83.63%, and pneumatosis intestinalis in 61.81% of subjects. Positive blood cultures were found in 63.63% of subjects, with Staphylococcus epidermidis and Klebsiella pneumoniae being the predominant organisms. Median survival was 27 days and 31 days for infants born at <32 weeks and ?32 weeks gestational age, respectively (P=0.37). Median survival was 27 and 28 days in infants with early-onset and late-onset NEC, respectively (P=0.07), and 23 and 28 days in infants with birth weight of <1,000 grams and ?1,000 grams, respectively (P=0.14).
Conclusion The incidence of NEC among preterm infants born in Cipto Mangunkusumo Hospital in 2019 was 8.6%. The survival rate of infants with NEC was 27.27%. Early-onset and late-onset NEC had similar mortality rates.
High Accuracy in Classifying Endoscopic Severity in Ulcerative Colitis Using Convolutional Neural Network
Authors: Lo Bobby , Liu ZhuoYuan , Bendtsen Flemming , Igel Christian , Vind Ida , Burisch Johan 
Published: July 2022

Introduction:
The evaluation of endoscopic disease severity is a crucial component in managing patients with ulcerative colitis (UC). However, endoscopic assessment suffers from substantial intraobserver and interobserver variations, limiting the reliability of individual assessments. Therefore, we aimed to develop a deep learning model capable of distinguishing active from healed mucosa and differentiating between different endoscopic disease severity degrees.

Methods:
One thousand four hundred eighty-four unique endoscopic images from 467 patients were extracted for classification. Two experts classified all images independently of one another according to the Mayo endoscopic subscore (MES). In cases of disagreement, a third expert classified the images. Different convolutional neural networks were considered for automatically classifying UC severity. Five-fold cross-validation was used to develop and select the final model. Afterward, unseen test data sets were used for model evaluation.

Results:
In the most challenging task—distinguishing between all categories of MES—our final model achieved a test accuracy of 0.84. When evaluating this model on the binary tasks of distinguishing MES 0 vs 1–3 and 0–1 vs 2–3, it achieved accuracies of 0.94 and 0.93 and areas under the receiver operating characteristic curves of 0.997 and 0.998, respectively.

Discussion:
We have developed a highly accurate, new, automated way of evaluating endoscopic images from patients with UC. We have demonstrated how our deep learning model is capable of distinguishing between all 4 MES levels of activity. This new automated approach may optimize and standardize the evaluation of disease severity measured by the MES across centers no matter the level of medical expertise.
Immersing learners in stories: A systematic literature review of educational narratives in virtual reality
Authors: Calvert James , Hume Margee 
Published: July 2022

The aim of this study, via a systematic review, was to investigate the addition of narratives in immersive virtual reality (IVR) and the associated impacts on learning. Narratives in IVR put the learner in the story, which, until recent developments in IVR head-mounted display technology, was out of reach in most classrooms. The review found that added immersion afforded by VR is particularly important in relation to learning where situational context is desirable. Importantly, IVR experiences with a narrative may have the potential to increase affective outcomes for learners, without reducing cognitive gains. Additionally, data concerning learning theories and design methodologies was extracted from the studies. The systematic review yielded 12 relevant and applied papers with this demonstrating there are still significant gaps in the research concerning the impact on learning in narrative IVR. This review highlights that the inclusion of narratives in educational IVR offers many potential benefits, however is yet to be fully explored. There are endless opportunities to tell stories in IVR. How they can be used and their impact on education is a rich ground for further research and development.
Implications for practice or policy

Educators and VR developers should consider including a narrative in an educational IVR experience because of the potential to increase affective outcomes such as motivation and engagement, without reducing cognitive gains.
Learners can benefit from educational IVR experiences with narratives because they can provide situational context, elicit an emotional response and scaffold complex learning.