bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fragmentos da complexidade e dos fundamentos da política educacional
Authors: Miranda de Oliveira José Manoel Miranda de Oliveira 
Published: May 2022

As discussões postas neste texto partem da práxis ancorada no desenvolvimento dos saberes escolares que, segundo Santos (2004; 2013), representam o momento em que essa complexidade da produçãode conhecimentos passa a contar com a inserção do estado, mesmo que essa produção, em dado momento, o estado é o próprio alvo. Por isso, é impossível discutir a educação sem uma aproximação do contexto das Ciências Sociais e da Filosofia, do nascedouro do pensamento liberal às suas antíteses. Por conseguinte, a complexidade posta sobre a educaçãopartirá das contradições apresentadas por Santos (2013) sobre as funções constituídas pelo sistema educativo, no momento em que as ações e os objetos produzidos ou reproduzidos são detectáveis entre as funções sociais, econômicas e políticas. Considera-se que as políticas educacionais, ao se inserirem em diferentes espaços e tempos, direta ou indireta reproduzem uma fragmentação social de difícil compreensão, diante dos interesses generalizados dentro e fora das esferas públicas, reproduzidas no momento em que ocorre a subordinação das políticas educacionais ao processo de acumulação capitalista. Estes são os principais pontos abordados neste texto.
Cooperativas, Altruismo y Compromiso Político: contribuciones para el debate latinoamericano sobre Economía Solidaria
Authors: Spognardi Andrés 
Published: May 2022

A menudo, los estudiosos latinoamericanos de la economía solidaria tras anua línea divisoria entre las pequeñas y las grandes cooperativas. Las primeras son presentadas como organizaciones solidarias, orientadas a lograr una amplia gama de objetivos política y socialmente deseables; las segundas como empresas motivadas por el lucro, únicamente guindadas por los imperativoscomerciales del mercado. El presente artículo cuestiona esta visión. Tomando como marco de referencia la experiencia del cooperativismo de crédito en Argentina, se argumenta que el aumento de la dimensión y de la complejidad de una cooperativa no necesariamente afecta sus fundamentos solidarios o su compromiso político. El artículo también destaca las diferentes lógicas dela cooperación, alertando sobre la necesidad de evitar el uso del término “capitalista” para referirse a aquellas cooperativas que están fundadas sobre el principio dela racionalidad instrumental.
O Habitus moderno na educação profissional
Authors: Leite Amorim Rômulo , Vasconcelos Gico Vânia 
Published: May 2022

Busca-se a partir dos estudos da Colonialidade e o surgimento doParadigma Emergente compreender através da sociologia reflexiva o modo comoa Modernidade estruturou-se como uma maneira de ordenar o saber e o ser, a partir da Colonização do campo da Educação, a ponto de determinar que o ensino profissional tenha o caráter único de formar mão-de-obra para o mercado de trabalho numa perspectiva colonial, induzindo a formação de como lidar com a ciência e a prática educacional que conserva o habitus colonial no campo da educação. Procura-se, a partir de um ensaio e referenciais clássicos das ciências sociais e revisão bibliográfica, elaborar uma reflexão sobre o processo de educação desenvolvido no Instituto Federal de Educação, Ciência eTecnologia da Paraíba - IFPB, com base nas contribuições e críticas advindas dos estudos sobre Colonialidade. Conclui-se que a expansão dos Institutos Federais possibilitou um maior acesso à educação dos jovens, porém, formam-se geralmente, com uma visão que favorece o mercado e seus produtos (egressos de cursos), iludindo-se ao pensarem que estão preparados e capazes de atenderas exigências dos novos empregos, a partir da competência técnica especializada.
A sociologia das ausências e das emergências em sala de aula
Authors: Gomes Ana Laudelina Ferreira 
Published: May 2022

SANTOS, Boaventura de Souza. A crítica da razão indolente: contra o desperdício da experiência. Para um novo senso comum. Vol. 1. 4a. ed. São Paulo: Cortez, 2002.SANTOS, Boaventura de Souza. A gramática do tempo. Para uma novacultura política. Vol. 4. 2ª. Ed. São Paulo: Cortez, 2008.
PROJETARCOM: UMA REFLEXÃO CRÍTICA FUNDAMENTADA NA TEORIA ATOR-REDE
Authors: Fernandes de Britto Tanara , Rheingantz Paulo Afonso , Borda Almeida da Silva Adriane 
Published: May 2022

As múltiplas realidades em constante transformação do mundo contemporâneo complexificam o processo de projeto em arquitetura-urbanismo. Em consonância com os fundamentos dos estudos Ciência-Tecnologia-Sociedade (CTS) e da Teoria Ator-Rede (TAR), este artigo apresenta uma visão alternativa da ação projetual a partir do entendimento do projeto de arquitetura como um artefato sociotécnico que performa uma construção coletiva cujas redes híbridas articulam e associam atores humanos e não-humanos. O artigo explora tentativas de definição do termo projeto e da ação projetual e reúne proposições sobre os tipos de problemas de projeto e sobre a integração dos saberes por meio de questões disciplinares, com o objetivo fazer um movimento em direção ao projetarCOM a partir da proposição de reflexões sobre os cinco pressupostos que o delineam. Tomadas à luz da TAR, questões de autoria são abordadas a partir do reconhecimento de que a origem da ação é reduzida e distribuída, e que a capacidade de agência de tudo e todos implica num afastamento de reivindicações de autoria exclusiva. Nesse sentido, buscamos colaborar para o entendimento de que as tentativas de simplificação do processo projetual ao rigor de uma atividade técnica se afastam da indeterminação e perversidade inerentes de seus problemas, bem como da complexidade e não-linearidade das redes que o sustentam.
Current Applications and Benefits of Polymeric Nanocarriers for the
Management of Skin Disorders
Authors: Pierre Maria Bernadete Riemma 
Published: May 2022

Abstract:
Preparations for topical application are highly important for therapeutic and
cosmetic use since the skin has an extensive and accessible application area. Among the
many advantages, this route avoids the systemic effects of the substances and, therefore,
fewer adverse reactions are observed. However, the skin is an organ with a remarkable
barrier effect, which can compromise the administration of pharmacologically / cosmetologically
active molecules. Thus, the skin permeability of substances is a challenge that
is only achieved through the preparation of formulations capable of overcoming that
same barrier. Nanotechnology was introduced in the pharmaceutical and cosmetic areas
to enable the development of systems for the delivery of substances and the optimization
of already existing formulations. Among the several benefits and advantages of nanotechnology
for topical application is the increased penetration of the drug in the skin, the improvement
of the stability of the active, decrease in the active substances (reducing the
possible toxic effects and allergic reactions caused by the high concentration of these
compounds), and even the intensification of the drug action. This manuscript reviews the
topical delivery technologies based on polymeric nanocarriers (PNC) as nanoparticles (NP)
and nanogels (NG) and their benefits for better efficacy in most common cutaneous disorders.
It starts with skin properties, the aspects for the penetration of active ingredients
in the skin and cutaneous penetration challenges, followed by a summary of strategies for
skin penetration/permeation of drugs. Then, the focus of the current research was to review
NPs and NGs explored for skin disorders management published during the last
years.
MicroRNAs and their Implications in CD4+ T-cells,
Oligodendrocytes and Dendritic Cells in Multiple Sclerosis
Pathogenesis
Authors: Safari Armin , Madadi Soheil , Schwarzenbach Heidi , Soleimani Mohsen , Safari Armita , Ahmadi Mohammad , Soleimani Meysam 
Published: May 2022

Abstract:
MicroRNAs (miRNAs) have been established as key players in various biological processes regulating differentiation, proliferation, inflammation, and autoimmune disorders. Emerging evidence suggests the critical role of miRNAs in the pathogenesis of multiple sclerosis (M.S.). Here, we provide a comprehensive overview on miRNAs which are differentially expressed in M.S. patients or experimental autoimmune encephalomyelitis (EAE) mice and contribute to M.S. pathogenesis through regulating diverse pathways including CD4+ T cells proliferation, differentiation, and activation in three subtypes of CD4+ T cells including Th1, Th17 and regulatory T cells (Tregs). Moreover, regulation of oligodendrocyte precursor cells (OPC) differentiation as a crucial player of M.S. pathogenesis is also described. Our literature research showed that miR-223 could affect different pathways involved in M.S. pathogenesis, such as promoting Th1 differentiation, activating the M2 phenotype of myeloid cells, and clearing myelin debris. MiR-223 was also identified as a potential biomarker, distinguishing relapsing-remitting multiple sclerosis (RRMS) from progressive multiple sclerosis (PMS), and thus, it may be an attractive target for further investigations. Our overview provides a novel, potential therapeutic targets for the treatment and new insights into miRNAs' role in M.S. pathogenesis.
Synthesis and Characterization of Some New Spirothiadiazole Oxindoles
and their Mannich Bases
Authors: Sim Kooi-Mow , Leong Pei-Theng , Wong Wai-Sum , Teo Kah-Cheng 
Published: May 2022

Abstract:
A series of new spirothiadiazole oxindoles were synthesized by the reaction of 4-amino-5-
mercapto-3-[(1H-indol-3-yl)methyl]-1,2,4-triazole and isatin derivatives. The reaction of spiro [indole]
thiadiazoles with formaldehyde and piperidine afforded the corresponding Mannich bases. The structures
of newly synthesized compounds were characterized by IR, 1D-NMR, 2D-NMR, and LC/MS
spectral data.
Post-COVID-19 Pulmonary Hypertension: How it May Physiologically
Affect Exercise Training
Authors: Hashim Natiara Mohamad , Ibrahim Muhammad Amin , Ahmedy Fatimah , Ibrahim Khairul Shafiq , Zohdi Wan Najwa Wan Mohd , Roslan Nor Faridah Ahmad 
Published: May 2022

Abstract:
Exercise training is paramount in improving aerobic capacity, lung function, reducing the symptoms of dyspnea, and reconditioning the lean skeletal muscles. Many literature and guidelines have advocated the importance of exercise intervention in addressing the secondary impairment to post covid-19 infection, including home-based therapy and telerehabilitation. Pulmonary hyperten-sion (PH) was previously thought to be contraindicated by exercise training; however, exercise was later found to be beneficial and relatively safe in chronic PH. However, there is a lack of high-quality evidence on the safety and effectiveness of exercise training in post-COVID-19 infected in-dividuals with PH. Pulmonary hypertension has been documented to be one of the post-COVID-19 complications. PH occurred due to COVID-19 infection should be carefully considered before sub-jecting them to exercise training, especially in home-based therapy. This article aims to discuss the differing etiological factor, pathophysiological backgrounds, and the possible disease long-term outcomes that may compromise the safety of exercise training in post-COVID-19 patients compli-cated with PH. By understanding the risk of developing PH, risk assessment and stratification can be explicitly outlined for a safe exercise prescription through proper patient selections. Any possible complications can be anticipated; hence, proper preventive strategies can be instituted.
Optical Properties of a Composite System with Nematic LC and Colloids Quantum Dots
Authors: Galyametdinov Yuriy , Osipova V. , Kurilov A. , Belyaev V. , Chausov D. , Belyaev A. 
Published: May 2022

Background:
Optical luminescence in a composite system with nematic LC 4-
octyloxy-4’-cyanobuphenyl (8OCB) and semiconductor quantum dots CdSe/CdS and
CdSe/CdS/ZnS has been synthesized by a water-organic method.

Methods:
Composites have been investigated by means of polarizing microscopy, dynamic light
scattering, and measurements of dielectric properties in the frequency range from 20 Hz to 5
MHz. The non-radiative excitation energy transfer from the liquid crystal molecules to the quantum
dot in the LC-QD composite is detected by using the luminescence spectroscopy method.

Results:
This effect as well as the shift of the luminescence band is owing to components’ intermolecular
interaction.

Conclusion:
The optimal concentration of QD in a composite that enhanced luminescence intensity
was detected.
Analysis of Intoxication, Rehospitalization, and One-year Survival of
Heart Failure Patients Receiving Digoxin at Harapan Kita National Cardiovascular
Center, Jakarta, Indonesia: A Cross Section-observational Study
Authors: Nafrialdi Nafrialdi , Tiaranita Cindy , Suyatna Fransiscus D. , Siswanto Bambang Budi 
Published: May 2022

Background:
Despite being the oldest therapy for heart failure, the use of digoxin is still controversial due to narrow margin of safety. In Indonesia, digoxin is still considered as one of treatment for heart failure. However, analysis of intoxication have never been reported. This study aims to analyze the occurrence of digoxin intoxication, rate of rehospitalization and one-year survival in heart failure patients under digoxin treatment.

Methods:
A cross section-observational study was conducted at Harapan Kita National Cardiovascular Centre from January 2017 to December 2018 on heart failure patients who received digoxin therapy and had data of serum digoxin level. Intoxication was defined as the presence of specific ECG alteration(s), at least one extra-cardiac symptom(s) and further classified as definite (serum digoxin >2 ng/mL), probable (serum digoxin 0.91-1.99 ng/mL), or possible (serum digoxin 0.5-0.9 ng/mL). Risk factors of intoxication were analyzed by Chi-square test, and one-year survival was analyzed with Kaplan Meyer method.

Results:
54 of 195 patients (27.69%) were classified as having intoxication, consisting of 32 (16.41%) definite, 19 (9.74%) probable, and 3 (1.54%) possible. Renal insufficiency was revealed as a significant influencing factor of digoxin intoxication with RR 2.48 (CI
1.13-5.464, p=0.016). Overall one-year survival of patients receiving digoxin was 259 days in the intoxication group and 307 days in the non-intoxication group. One-year rehospitalization was 11.8% in patients who received digoxin, and 29.2% in those without digoxin (p=0.085).

Conclusion:
The proportion of digoxin intoxication in heart failure patients was 27.69%. Renal insufficiency was revealed as a significant influencing factor of intoxication. There was a tendency of reduced hospitalization in those who received digoxin.
Therapeutic Drug Monitoring of Tacrolimus in Tunisian Renal Transplant
Patients during the Tuberculosis Infection: A Retrospective, Observational,
Single-centre Analysis
Authors: Ammar Helmi , Sassi Mouna Ben , Charfi Rim , Jebar Hanene El , Daghfous Riadh , Gaies Emna , Trabelsi Sameh 
Published: May 2022

Abstract:
Tuberculosis is a challenge in organ transplantation due to the interaction between Anti-
Tuberculosis Treatment (ATT) and immunosuppressive drugs, such as Tacrolimus (TAC). This
study aimed to assess this interaction and discuss the guidelines used in this specific case.

Methods:
A retrospective, observational, single-center analysis was performed at the Department
of Clinical Pharmacology (National Centre of Pharmacovigilance, Tunisia). We analyzed the database
of patients who received TAC from 2009 until 2018. We included samples provided from renal
transplant patients infected by Mycobacterium tuberculosis after transplantation. Trough blood
levels (C0) were determined using an immunoassay analyzer. The Therapeutic Range (TR) of TAC
was considered between 5 and 10 ng/mL. Pharmacokinetic parameters were compared between the
period of co-administration of TAC/ATT (period A) and the period during which patients received
only TAC (period B).

Results:
Seven renal transplant patients treated by TAC were included. 41 samples were analyzed
(16; period A, 25; period B). Only 6 % of C0 values were found within TR during period A, while
this rate was 44% during period B. During period A, 88% of TAC C0 was under the lower limit of
TR, indicating a high risk of transplant rejection. The mean C0 and C0/D were significantly lower
during period A (3.11±1.53 ng/mL vs 7.11 ± 3.37 ng/mL; p = 0.001 and 33.06 ± 24.89 vs 83.14 ±
44.46; p = 0.0006, respectively), without difference in doses between periods.

Conclusion:
Considering the results of this study, clinicians are suggested to monitor TAC closely
in this particular circumstance.
Drug-induced Sudden Death: A Scoping Review
Authors: Amaro-Hosey Kristopher , Castells Xavier , Blanco-Silvente Lidia , Loma-Osorio Pablo , Capellà Dolors 
Published: May 2022

Background:
The risk of sudden cardiac death (SCD) can be increased with the use of
drugs. However, it has been described heterogeneously in the literature.

Objective:
This study aims to systematically review epidemiological studies dealing with druginduced
sudden death, describe their methodologies, and summarize the results found.

Methods:
A scoping review has been carried out using Medline electronic database. The search
was limited up to 2020. Epidemiological studies were included, and case reports or case series
were excluded.

Results:
Out of 3,114 potential articles, 74 were included. Most studies originated from North
America (40.5%) or Europe (39.2%). Case-control (47.3%) or cohort (40.5%) studies were the
most common designs. The data for outcomes and exposure were retrieved mainly from administrative
databases (37.8%) or medical charts/hospital discharge reports (32.4%), but most studies
used several sources of information. A composite variable of sudden death or SCD, mainly with
ventricular arrhythmia, was the most frequently used endpoint. Only 18.9% of the studies included
autopsy results to confirm the death. Psychotropic drugs were the most frequently studied. An increased
risk of different outcomes for typical antipsychotics, tricyclic antidepressants, domperidone,
and antiepileptics is suggested.

Conclusion:
The methodologies used were highly heterogeneous, and the results were, in general,
not conclusive. An improvement of the methodologies is needed to achieve a conclusion regarding
the risk of SCD associated with drug use.
Medicinal Importance, Pharmacological Activities, and Analytical Aspects
of Engeletin in Medicine: Therapeutic Benefit Through Scientific Data
Analysis
Authors: Patel Dinesh Kumar 
Published: May 2022

Background:
Phytochemicals belonging to the class of flavonoids have been used in medicine
for the treatment of different kinds of human health complications. Flavonoids have beneficial
health aspects in medicine mainly due to their anti-microbial, anti-diabetic, anti-inflammatory, anticancer,
and anti-carcinogenic activities. They have been scientifically investigated for their health benefit
and pharmacological activities in medicine. Engeletin is a pure flavanonol class phytocompound
present in the skin of white grapes and white wine. Engeletin has numerous pharmacological activities
in medicine.

Methods:
In order to know the beneficial health aspects of engeletin in medicine, scientific data on
engeletin have been collected from different literature sources and analyzed in the present work. The
present work summarized the important findings of engeletin with respect to its medicinal uses, pharmacological
activities, and analytical aspects in medicine. All the scientific data were collected from
PubMed, Google, Scopus, Science Direct and Google Scholar and analyzed in the present work.

Results:
Scientific data analysis of research works revealed the biological importance and therapeutic
benefit of engeletin in medicine. Engeletin has attracted scientific attention mainly due to its antiinflammatory
and anti-tumor potential. Engeletin could inhibit the occurrence of cervical cancer and
delay the development of liver damage and lung cancer in mice. Engeletin was found to inhibit lipopolysaccharides-
induced endometritis in mice by inhibiting the inflammatory response. Pharmacological
data analysis revealed the therapeutic importance of engeletin against acute lung injury, inflammatory
diseases, liver injury, pulmonary fibrogenesis, Alzheimer’s disease, endometritis, cervical carcinogenesis,
lung cancer, and osteoarthritis. Analytical data signified the importance of modern analytical
tools for separating, isolating, and identifying engeletin.

Conclusion:
Scientific data analysis revealed the biological importance and therapeutic benefit of
engeletin in medicine and other allied health sectors.
Photocatalytic Degradation of Methylene Blue Dye Using Cuprous Oxide/
Graphene Nanocomposite
Authors: Melak Fekadu , Bogale Bekan , Asere Tsegaye Girma , Yai Tilahun 
Published: May 2022

Aims:
The aim of this study is to evaluate the photocatalytic degradation of methylene blue
dye on cuprous oxide/graphene nanocomposite.

Background:
Cuprous oxide (Cu2O) nanoparticles are among the metal oxides that demonstrated photocatalytic
activity. However, the stability of Cu2O nanoparticles due to the fast recombination rate of
electron/hole pairs remains a significant challenge in their photocatalytic applications. This in turn,
leads to mismatching of the effective bandgap separation, tending to reduce the photocatalytic activity
of the desired organic waste (MB). To overcome these limitations, graphene has been added to make
nanocomposites with cuprous oxides.

Objective:
In this study, Cu2O/graphene nanocomposite was synthesized and evaluated for its photocatalytic
performance of Methylene Blue (MB) dye degradation.

Method:
Cu2O/graphene nanocomposites were synthesized from graphite powder and copper nitrate
using facile sol-gel method. Batch experiments have been conducted to assess the applications of the
nanocomposites for MB degradation. Parameters such as contact time, catalyst dosage, and pH of the
solution were optimized for maximum MB degradation. The prepared nanocomposites were characterized
by using UV-Vis, FTIR, XRD, and SEM. The photocatalytic performance of Cu2O/graphene
nanocomposites was compared against Cu2O nanoparticles for cationic MB dye degradation.

Results:
Cu2O/graphene nanocomposite exhibits higher photocatalytic activity for MB degradation
(with a degradation efficiency of 94%) than pure Cu2O nanoparticle (67%). This has been accomplished
after 180 min of irradiation under visible light. The kinetics of MB degradation by
Cu2O/graphene composites can be demonstrated by the second-order kinetic model. The synthesized
nanocomposite can be used for more than three cycles of phtocatalytic MB degradation.

Conclusion:
This work indicated new insights into Cu2O/graphene nanocomposite as highperformance
in photocatalysis to degrade MB, playing a great role in environmental protection in relation
to MB dye.