bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Type 2 Symptomatic Ulnar Styloid Nonunions with Reinsertion of the Triangular Fibrocartilage Complex
Authors: Yu Xiaofei , Yu Yadong , Zhang Xu , Li Jia , Zhou Tong , Chen Huan 
Published: August 2022

Abstract
Purpose
The purpose of this retrospective study was to introduce an alternative technique for the treatment of type 2 symptomatic ulnar styloid nonunion by reinsertion of triangular fibrocartilage complex and ulnar collateral ligament.
Methods
Between March 2009 and May 2017, 45 patients who suffered nonunion of the type II ulnar styloid fractures were enrolled. All patients underwent subperiosteal resection of the avulsed fragments and reinsertion of the TFCC and ulnar collateral ligament. Outcome assessments included range of the motion of the wrist, grip strength, pain, and Mayo wrist score. The preoperative and postoperative parameters were compared. A P value less than 0.05 was considered statistically significant.
Result
The mean follow-up period was 21.66 ± 7.93 months (range, 12 to 26 months). At the final follow-up, the mean preoperative flexion and extension were 79.32 ± 4.52° and 74.40 ± 4.36°, respectively. The mean preoperative pain score, grip strength, Mayo wrist score were 32.48 ± 4.00; 23.88 ± 8.38 kg, and 77.72 ± 8.31, respectively. The mean postoperative flexion and extension of the wrist were 80.56 ± 6.32° and 75.43 ± 3.12°, respectively. The mean postoperative pain score, grip strength, Mayo wrist score were 12.41 ± 3.27, 26.31 ± 8.30 kg, and 90.71 ± 7.97, respectively. There were significant differences with respect to pain, grip strength, and Mayo wrist score (P < 0.05), but no significant differences with respect to range of motion of the wrist.
Conclusion
In the treatment of nonunion of the type II ulnar styloid fractures, resection of the avulsed fragments followed by reinsertion the TFCC and ulnar collateral ligament with an anchor was a reliable alternative technique, resulting in satisfactory function of the wrist.
Efforts to address the Sustainable Development Goals in Older Populations: a Scoping Review
Authors: Shevelkova Vlada , Mattocks Calum , Lafortune Louise 
Published: August 2022

Abstract
Background
The United Nations Decade of Healthy Ageing (2021–2030) seeks to create multisectoral changes that align healthy ageing with the U.N.’s Sustainable Development Goals (SDGs). Given that the SDGs have completed their first five years, this scoping review explores whether any efforts have been launched to directly address the SDGs in older adults in community settings. Prior to the Decade, no studies had explored this question.
Methods
Following Cochrane guidelines for scoping reviews, searches were conducted in three electronic databases, five grey-literature websites, and one search engine between April to May 2021; and limited to entries from 2016 to 2020. Abstracts and full texts were double-screened; references of included papers were searched to identify additional candidate publications; and data were extracted independently by two authors, using an adaptation of existing frameworks. Quality assessment was not conducted.
Results
In total, we identified 617 peer-review papers, of which only two were included in the review. Grey literature searches generated 31 results, from which ten were included. Overall, the literature was sparse and heterogeneous, consisting of five reports, three policy documents, two non-systematic reviews, one city plan, and one policy appraisal. Initiatives targeting older adults were mentioned under 12 different SDGs, with SDG 1 (No Poverty), SDG 3 (Good Health and Wellbeing), SDG 10 (Reduced Inequalities), and SDG 11 (Sustainable Cities and Communities) being the most commonly discussed. Also, SDG-based efforts frequently overlapped or aligned to the eight domains of age-friendly environments outlined in the World Health Organisation framework.
Conclusion
The review has documented the extent, range, and nature of available research and provided an evidence backdrop for future research and policy development.
Decoding promoter-enhancer interactions in human cardiac myocytes
Authors: Bednarz Rebecca , Laurette Patrick , Pedrosa Núria Díaz i , Lahm Harald , Dressen Martina , Krane Markus , Streckfuß-Bömeke Katrin , Gilsbach Ralf 
Published: August 2022

Abstract

The heart is a heterocellular organ consisting of several cell types including cardiomyocytes. Cell-type specific gene expression and response to stimuli is modulated by active distal regulatory elements termed enhancers. Cardiac enhancers are enriched for disease-associated variants and spatially interact with distal target promoters. However, enhancer-promoter interactions and spatial chromatin organization of human adult cardiac myocytes have not been analyzed so far limiting the interpretation of disease-associated regulatory elements in these cells. Here we generated high resolution spatial chromatin interaction data for atrial, left ventricular and failing human adult cardiac myocytes and identified cell-type specific interaction signatures. An integrative analysis with comprehensive epigenetic data reveals cardiac myocyte-specific, chamber-specific and disease-relevant enhancer-promoter interactions in cardiac myocytes. We further identified the cardiac disease risk association of promoter-interacting versus non-interacting enhancers and experimentally proofed the functional importance of enhancers harboring long QT risk loci. Our data shows that decoding cell type-specific regulatory elements and their interacting promoters provides insights into regulatory mechanisms essential for cell function and genetic risk factors as demonstrated here for human cardiac myocytes. This data will facilitate the interpretation of non-coding genetic risk factors in future genome-wide association studies. These data will allow predicting whether non-coding genetic variants promote disease in adult cardiac myocytes or not.
Fault decomposition based convergent FE and FTC for Lipschitz nonlinear systems
Authors: Wang Hong-Jun , Huang Sheng-Juan 
Published: August 2022

Abstract
The problem of fault estimation and fault tolerant control for Lipschitz nonlinear systems subject to actuator and sensor faults is investigated in this paper. A fault decomposition technique is introduced to design a set of iterative estimation observers for the system in consideration. The obtained mean sequence of estimates, under certain conditions, converge to the true values of state and multi-faults. A convergence theory with a theoretical proof is given. A sufficient LMIbased stability condition dependent on the coefficient matrix of disturbance is proposed to determined the observer gains. Finally, an output feedback FTC is designed to stabilize the Lipschitz nonlinear system. The longitudinal dynamics of an aircraft is applied to test the proposed method.
A novel wide-range colorimetric glucose biosensor based on enzymatic etching of triangular gold nanosheets
Authors: Xu Bing , Xiang Xiaoying , Luo Zhihui , Huang Jianglou 
Published: August 2022

Abstract
Blood glucose detection is an essential of diabetes management, so it is urgent to develop a convenient and practical blood glucose monitoring method. Herein, a wide range colorimetric assay for the detection of glucose based on enzymatic etching of triangular gold nanosheets was reported. In the presence of glucose oxidase (GOD) catalyzed the oxidation of glucose to produce hydrogen peroxide (H2O2), which induced the etching of triangular gold nanosheets (AuTNPs) from triangular to round. The shape and size of the AuTNPs changed. Both enzymatic reaction and H2O2 etching can lead to LSPR displacement. Then the etching mechanism is closely related to the concentration of AuTNPs, the high sensitivity of this assay at low concentration particle AuTNPs. The ratio and concentration of EDC/NHS, pH value of phosphate buffered solution (PBS) and GOD concentration were studied, and the best detection conditions of glucose were determined. Under the optimal detection conditions, this glucose colorimetric sensor exhibits excellent sensing performance in the glucose range of 0.2 to 12 mM and the limit of detection is limit 0.1mM (S/N = 3). In addition, glucose was tested in artificial fluids. The results demonstrated that the colorimetric analysis based on triangular gold nanosheets-glucose oxidase system performs in artificial fluids as well as in phosphate buffer solution, making it very suitable for the clinical diagnosis of diabetes.
Social Desirability and Central Tendency Bias in the Survey and Variation of Life Satisfaction
Authors: Klement Johannes 
Published: August 2022

Abstract
Even though life satisfaction is an empirically extensively researched well-being concept, there are still open questions regarding the variation of life satisfaction and the influence of variables that are not collected in data sets such as the German Socio-Economic Panel (SOEP).In this article, I explore the question to what extent the variation of life satisfaction is influenced by biases resulting from the setting of the life satisfaction survey. Using different methodological approaches, including distributional analysis, descriptive statistics, Markov transition probabilities and logistic regression, I investigate to what extent a possible central tendency or social desirability bias influences the variation of life satisfaction. This brings me to the following conclusions:1. People who are interviewed in the presence of an interviewer are more satisfied with their life than people who are interviewed in writing without an interviewer. This suggests that people express themselves more positively about their well-being in the presence of others.2. On the 11-point integer life satisfaction scale defined between 0 and 10, the interviewees prefer to choose points 5 and 8, which form the midpoints of the scale, and choose these also repeatedly more often than other points. This is important for adaptation research: it suggests that people prefer to report life satisfaction that is balanced between good and bad, leaving room for improvement even in satisfied states.The social desirability and central tendency bias have a stronger influence on the variation of life satisfaction than many happiness correlates examined. Regarding the growth of life satisfaction, point 8 seems to be the maximum on average. A higher value is implausible on the basis of the study results.
Central nervous system relapse in younger patients with diffuse large B-cell lymphoma - a LYSA and GLA/ DSHNHL analysis
Authors: Thieblemont Catherine , Altmann Bettina , Frontzek Fabian , Renaud Loïc , Chartier Loic , Ketterer Nicolas , Recher Christian , Poeschel Viola , Fitoussi Olivier , Held Gerhard , Casasnovas René-Olivier , Haioun Corinne , Morschhauser Franck , Glass Bertram , Mounier Nicolas , Tilly Hervé , Rosenwald Andreas , Ott German , Lenz Georg , Molina Thierry , Ziepert Marita , Schmitz Norbert 
Published: August 2022

Abstract
The majority of patients with diffuse large B-cell lymphoma (DLBCL) can be cured with immunochemotherapy comprising rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Patients suffering progression or relapse in the central nervous system (CNS) face dismal outcomes. The impact of more aggressive regimens used in front-line therapy has not systematically been investigated in this context. To this end, we analyzed a large cohort of 2203 younger DLBCL patients treated on ten German and French prospective phase II and III trials following first-line therapy with R-CHOP, R-CHOEP (R-CHOP + etoposide), dose-escalated R-CHOEP followed by repetitive stem cell transplantation (R-MegaCHOEP), or rituximab, doxorubicin, cyclophosphamide, vindesine, bleomycine, prednisone (R-ACVBP) followed by consolidation including multiple drugs crossing the blood-brain-barrier (BBB). DLBCL patients with age-adjusted International Prognostic Index (aaIPI) of 0–1 showed very low cumulative incidence (CI) rates of CNS relapse regardless of first-line therapy and CNS prophylaxis (3-year CI 0% − 1%). Younger high-risk patients with aaIPI of 2–3 had 3-year CI rates of 1.6% and 4% after R-ACVBP plus consolidation or R-(Mega)CHO(E)P, respectively (Hazard Ratio 2.4 (95% confidence interval: 0.8–7.4), p = 0.118). Thus, for younger high-risk patients, front-line regimens incorporating multiple agents crossing the BBB may reduce often fatal CNS relapse.
Facilitation between species mitigates nutrient constraints in grassland
Authors: Zhang Wei , Maxwell Thomas M. R. , Robinson Brett , Dickinson Nicholas 
Published: August 2022

AbstractBackgroundExperimental work using pot trials and mesocosm studies has indicated that species combinations are more effective in mitigating the soil nutrient constraints that limit pasture productivity in New Zealand’s hill country, but there is little field evidence to support this.AimWe question whether coexistence of species provides an opportunity to facilitate enhanced uptake and improved procurement of key soil nutrients by assemblages of plants in these mid-altitude grasslands.MethodsNative and exotic legumes and co-occurring plant species were sampled according to whether they were growing together in close proximity or in single species patches. Foliar concentrations of nutrients were compared.ResultsUptake of nutrients by a native broom,Carmichaelia petriei, was enhanced when it was growing in combination with native tussock grasses. Enhanced uptake of eight nutrients was recorded in foliage of an exotic legume,Lotus pedunculatus, when it was growing with native grasses or within the acuminate foliage ofAciphylla aurea(golden spaniard). Foliar concentrations of only P and Mn were elevated in white clover (Trifolium repens) foliage when it was growing in combination with grasses. Overall, mutual facilitation of nutrient uptake by combinations of species growing together was in evidence.ConclusionsSome species that are less desirable from an agricultural perspective may improve acquisition of soil nutrients by the plant community. Novel native species assemblages represent an opportunity to refine pasture management. Exploiting combinations of plant species that facilitate optimal exploitation of nutrients could reduce fertiliser requirements, enhancing and protecting biodiversity in pastoral grasslands.
Rodent model preclinical assessment of PEGylated block copolymer targeting cognition and oxidative stress insults of Alzheimer’s disease
Authors: Chaudhury Sutapa Som , Nandi Mridula , Kumar Krishna , Ruidas Bhuban , Sur Tapas Kumar , Prasad Parash , Chakrabarti Saikat , De Priyadarsi , Sil Jaya , Mukhopadhyay Chitrangada Das 
Published: August 2022

Abstract
Misfolded peptide amyloid beta (Aβ42), neurofibrillary tangles of hyper-phosphorylated tau, oxidative damage to the brain, neuroinflammation are distinguished determinants of Alzheimer’s disease (AD) responsible for disease progression. This multifaceted neurodegenerative disease is challenging to cure under a single treatment regime until the key disease-determinants are traced for their sequential occurrence in disease progression. In an early report, a novel side-chain tripeptide containing PEGylated block copolymer has been tested thoroughly in vitro and in silico for the early inhibition of Aβ42-aggregation as well as degradation of preformed Aβ42-fibril deposits. The present study demonstrates a preclinical assessment of the PEGylated block copolymer in colchicine-induced AD mimicking rodent model. The colchicine induced Wistar rats receiving an intranasal delivery of the block copolymer at a daily dosage of 100 µg/kg and 200 µg/kg body weights respectively for 14 days manifested a notable attenuation of behavioral deficit pattern, oxidative stress, and neurotransmitters’ deficiency as compared to the untreated ones. The current study also reports the ameliorative property of the PEGylated compound for progressive neuroinflammation and decreased mitochondrial bioenergetics in astrocytoma cell line viz. U87. A closer look into the drug mechanism of action of a compact three-dimensional PEGylated block copolymer confirmed its disintegrative interaction with Aβ42 fibril via in silico simulation. The results obtained herein this study signify the potential of the novel PEGylated block copolymer to ameliorate the cognitive decline and progressive oxidative insults in AD, and may envision a successful clinical phase trial.
Catalytic reduction of 4-nitrophenol using Cu/Cu 2 O nanocomposites based on magnetic maize straw
Authors: Yu Yang , Guo Hong , Wang Pengyuan , Zhai Shangru , Han Jiazhi , Li Wangquan , Wang Yuanhao , Wang Yi 
Published: August 2022

Abstract

In this work, a novel copper-based nanocomposite catalyst was fabricated via magnetic maize straw as a support for the reduction of 4-nitrophenol (4-NP). Magnetic maize straw was prepared by the amidation reaction of amine-functionalized magnetite nanoparticles (NH2-Fe3O4) with succinylated maize straw (S-MS). After magnetic succinylated maize straw (Mag-S-MS) was mixed with cupric ions aqueous solution, Cu(II) could be captured by the amino and carboxylate groups and reduced by sodium borohydride (NaBH4). The reduction product of Cu(II) was characterized by scanning electron microscopy (SEM), energy disperse spectroscopy (EDS), X-rays diffraction (XRD), X-ray photoelectron Spectroscopy (XPS), and thermogravimetric analysis (TGA), which indicated binary Cu/Cu2O nanocomposites (NCs) were formed successfully on Mag-S-MS without self-aggregation and oxidation. Then it was investigated as a catalyst for the reduction of 4-NP to 4-aminophenol (4-AP) via hydrogenation using NaBH4 as a reducing agent. The effect of the dosage of the catalyst, the initial concentrations of NaBH4 and 4-NP were investigated. The mechanic investigation proposed Cu and Cu2O nanoparticles played a synergistic role on the hydrogen and electron transformation to enhance its catalytic ability. Compared with other reported catalysts, Cu/Cu2O NCs-loaded-Mag-S-MS possessed a higher catalytic efficiency for the higher rate constant value. Due to its superparamagnetic nature, it could be quickly collected from the aqueous solution under a magnetic field and it maintained relatively high catalytic activity after five cycle tests. The present study outlines a method for using agricultural waste in nano catalytic reaction.
Algorithm of crack skeleton backbone connection based on graph theory
Authors: Xue Dan , Liu Jun 
Published: August 2022

Abstract
When machine vision is used to monitor the health of tunnel lining structure, there are errors in measuring the crack length information due to the prevalence of fracture in the detected cracks. This paper proposes a graph theory based crack backbone connection algorithm. First, the morphological principle is used to describe the point characteristics of the crack skeleton line. Then the graph theory principle is employed to establish the tree structure of the crack skeleton line and the mapping relationship between them, converting the crack backbone extraction problem into a path optimization problem. Next, the complete connection of segment-by-segment cracks is completed according to the shortest path distance and direction continuity criterion. Finally, the burr removal effect and complete connection effect of the algorithm in this paper are compared with other baseline methods by experiments, respectively. The experimental results show that this algorithm is more accurate for crack connections. In addition, the effectiveness, necessity, robustness, and generalization of this algorithm are evaluated and demonstrated using multiple real scenarios, including e.g. houses and road pavements.
Proteomic and functional profiling of platelet-derived extracellular vesicles released under physiological or tumor-associated conditions
Authors: Torti Mauro , Vismara Mauro , Manfredi Marcello , Zarà Marta , Trivigno Silvia , Galgano Luca , Barbieri Silvia , Canobbio Ilaria , Guidetti Gianni 
Published: August 2022

Abstract
During hemostasis, thrombosis and inflammation, activated blood platelets release extracellular vesicles (PEVs) that represent biological mediators of physiological and pathological processes. We have recently demonstrated that the activation of platelets by breast cancer cells is accompanied by a massive release of PEVs, evidence that matches with the observation that breast cancer patients display increased levels of circulating PEVs. A core concept in PEVs biology is that their nature, composition and biological function are strongly influenced by the conditions that induced their release. In this study we have performed a comparative characterization of PEVs released by platelets upon activation with thrombin, a potent thrombotic stimulus, and upon exposure to the breast cancer cells line MDA-MB-231. By nanoparticle tracking analysis and tandem mass spectrometry we have characterized the two populations of PEVs, showing that the thrombotic and tumoral stimuli produced vesicles that largely differ in protein composition. The bioinformatic analysis of the proteomic data led to the identification of signaling pathways that can be differently affected by the two PEVs population in target cells. Specifically, we have demonstrated that both thrombin- and cancer cell-induced PEVs reduce the migration and potentiate Ca2+-induced apoptosis of Jurkat cells, but only thrombin-derived PEVs also potentiate cell necrosis. Our results demonstrate that stimulation of platelets by thrombotic or tumoral stimuli induces the release of PEVs with different protein composition that, in turn, may elicit selective biological responses in target cells.
Integrated genomic and transcriptomic elucidation of flowering in garlic
Authors: Shemesh-Mayer Einat , Faigenboim Adi , Ben-Michael Tomer , Kamenetsky-Goldstein Rina 
Published: August 2022

Abstract
Background
Commercial cultivars of garlic produce neither flowers nor seeds, and therefore efficient breeding of this important vegetable and medicinal crop is impossible. New avenues for hybridization and seed production were recently opened by the restoration of garlic fertility. The huge genome of garlic was fully sequenced in 2020 but, before that, transcriptome catalogs had been employed as a basis for garlic genetic studies. Here, we provide the conjoint genomic and transcriptome analysis of the regulatory network in flowering garlic genotypes.
Results
Our genome-wide analysis revealed phosphatidylethanolamine-binding proteins (PEBP) and LEAFY (LFY) genes that were not previously observed at the transcriptome level. Functions of TFL-like genes were reduced and probably replaced by FT-like homologs, whereas homologs of MFT-like genes were not found in the garlic genome. The discovery of three sequences of LFY-like genes in the garlic genome and confirmation of their alternative splicing suggest their key role in garlic florogenesis. It is not yet clear whether only one gene—AsLFY1—acts alone as the "pioneer transcription factor" or AsLFY2 also provides these functions.
Conclusions
The garlic genome, including key flowering genes, is highly repetitive. The presence of several orthologs of flowering genes that differ in their temporal and spatial expression and co-expression network advocates ongoing evolution in the garlic genome and diversification of gene functions. We propose that the process of fertility deprivation in garlic cultivars is based on the loss of transcriptional functions of the specific genes. Further comparisons of the genome and transcriptome factors in flowering and non-flowering garlic genotypes will clarify the possible evolution of their reproductive traits and contribute to fertility restoration and efficient breeding of this important crop.