bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic implication of an energy metabolism‐related 11‐gene signature in lung cancer
Authors: Zhou Yang , Wang Yuanhe 
Published: July 2022

AbstractEnergy metabolism therapy has gradually shown its potential in the treatment of tumor patients, but it has significant selectivity, thus distinguishing energy subtypes of lung adenocarcinoma (LUAD) is necessary to identify patients who may benefit from energy metabolism interference therapy. Gene expression data downloaded from The Cancer Genome Atlas and Gene Expression Omnibus, molecular subtypes were selected using NMF algorithm, prognostic differentially expressed genes (DEGs) were identified with DESeq. 2 and survival package, Lasso and cox regression analysis were used to Construct of Risk Signature. The relationship between molecular subtypes and prognosis as well as clinical characteristics were evaluated. Univariate and multivariate COX regression were used to analyze the correlation between the signature and patient prognosis. Based on 592 energy metabolism‐related genes, 430 LUAD samples were divided into three subtypes, of which C2 has the worst prognosis, and 942 prognostic DEGs were identified. 11‐gene prognostic risk signature was constructed. Compared with the traditional clinical features of T, N, and age, this 11‐gene signature performs better in predicting the risk of LUAD prognosis. At the same time, it is an independent risk factor for patient prognosis. The signature showed strong robustness in different cohorts. Compared with other published signatures, 11‐gene signatures have strong clinical applicability and accuracy. The predictive signature will enable patients with LUAD to be more accurately managed in clinical practice.
Investigating the role of residential migration history on the relationship between attachment and sense of belonging: A SEM approach
Authors: Esters Patric , Godor Brian P. , Van der Hallen Ruth 
Published: July 2022

AbstractWith the rate of both domestic and international migration steadily increasing, the psychological impact of residential migration remains largely unexplored. Attachment, the emotional bond we establish with those close to us, and sense of belonging, the feeling of connectedness to a community, may be vulnerable to frequent migration. This study investigates the association between individuals' early attachment style, sense of belonging, and migration history. A large international sample (N = 465) aged between 18 and 50 years old (M = 21.85; SD = 4.48), completed a survey on early attachment primary attachment style questionnaire (PASQ), sense of belonging (SOBI), and migration. Results comparing non‐movers (n = 240) to domestic movers (n = 52), international movers (n = 109), and domestic−international movers (n = 64), indicate important group differences related to early attachment and its relationship to one's sense of belonging. Moreover, insecure attachment was associated with increased migration early in life and, more in general, predictive of a negative sense of belonging later in life. Implications for both research and practice are discussed.
Compartment‐specific effects of muscle strength on bone microarchitecture in women at high risk of osteoporosis
Authors: Simon Alexander , Schäfer Hannah S. , Schmidt Felix N. , Stürznickel Julian , Amling Michael , Rolvien Tim 
Published: July 2022

AbstractBackgroundIt is well known that skeletal integrity is influenced by the musculature. Poor muscle strength (i.e. sarcopenia) is considered a major predictor of fragility fractures. While this observation appears particularly relevant for older women with increased risk of osteoporosis, there has been no comprehensive investigation to determine the influence of muscle performance on compartment‐specific bone microarchitecture in multiple body regions.MethodsWe retrospectively analysed data from different muscle performance and bone microarchitecture assessments in 230 women (aged 21 to 87 years) at high risk of osteoporosis. Muscle performance tests included grip strength and chair rising test (CRT) combined with mechanography. Balance was determined by Romberg posturography. Areal bone mineral density (BMD) was measured by dual‐energy X‐ray absorptiometry (DXA) at the hip and lumbar spine. Compartment‐specific volumetric BMD, microarchitecture, and geometry were assessed by second‐generation high‐resolution peripheral quantitative computed tomography (HR‐pQCT) at multiple skeletal sites (distal radius, tibia, and fibula). Regression models were applied to test for interactions between muscle and bone parameters. Subgroups were defined to compare women with osteoporosis and osteosarcopenia regarding BMD and microarchitecture.ResultsWhile osteoporosis was diagnosed in 115/230 (50.0%) women, sarcopenia was detected in 38/230 (16.5%). Positive associations of both grip strength and CRT maximum force with cortical geometric and microarchitectural parameters were detected at all measured sites, with the strongest effect applying to CRT maximum force and tibial parameters (e.g. tibial cortical area R2 = 0.36, P < 0.0001, and tibial cortical thickness R2 = 0.26, P < 0.0001). Balance parameters showed much weaker or no associations with HR‐pQCT parameters. Major associations between muscle strength and trabecular parameters could not be confirmed. Age and body mass index were confirmed as negative and positive predictors for several microarchitectural parameters, respectively. An independent predictive value of grip strength on radial, tibial, and fibular (all P < 0.01) cortical area and of CRT maximum relative force on cortical thickness (all P < 0.05) was revealed. Women with osteosarcopenia showed significantly reduced cortical HR‐pQCT parameters but no differences in DXA values compared with women with osteoporosis but no sarcopenia. Stratification by fracture and treatment status revealed that vertebral fractures and denosumab treatment altered the muscle–bone interaction.ConclusionsA systemic interaction between muscle strength and bone microarchitecture was demonstrated, and this interaction appears to be primarily with the cortical bone compartment. The value of muscle assessments in fracture risk evaluation may be partly mediated by their effects on bone microarchitecture.
Microbial community composition and soil metabolism in the coexisting Cordyceps militaris and Ophiocordyceps highlandensis
Authors: Xu Xiaorong , Zhang Xiaomei , Huang Zhipu , Xu Yuxiao , Tang Dexiang , Zhang Bing , Zhang Ketao , Liu Chaojin , Yu Hong 
Published: July 2022

AbstractCordyceps sensu lato is a complex fungus‐larva symbiote, and its distribution is affected by the geography, climate, soil environment, and cohabitating microorganisms. However, despite the fact Cordyceps militaris and Ophiocordyceps highlandensis are different species, they coexist in the Pinus armandi forest of Dashao in Songming County, Yunnan, China. We explored the microbial compositions and soil metabolism inhabited by C. militaris and O. highlandensis using high‐throughput sequencing and nontargeted metabonomics. The results indicated that the bacterial and fungal compositions in the soil microhabitat communities of C. militaris, O. highlandensis, and null Cordyceps group were similar. However, the community compositions in the fruiting bodies of C. militaris and O. highlandensis were different. The dominant phylum Ascomycota and dominant genus Cordyceps were detected in the fruiting body of C. militaris. Except for Ascomycota, the dominant phylum Chytridiomycota and dominant genera Ophiocordyceps, Unclassified_k__Hypocreales, Circinotrichum, Cladosporium, and Unclassified_k__chytridiomycetesg were detected in the fruiting body of O. highlandensis. The plant probiotic bacteria Phyllobacterium was detected in the fruiting body of C. militaris. The growth‐promoting bacteria Pseudomonas was detected in the fruiting body of O. highlandensis. Soil metabolism analysis revealed that pathways associated with amino acid metabolism was significantly enriched in O. highlandensis. Correlation analysis of bacterial diversity and soil metabolites revealed that the relative abundances of bacterial operational taxonomic units and the relative contents of metabolites were consistent. Our results provide insights into the microbial diversity and soil metabolism of naturally coexisting C. militaris and O. highlandensis.
Prediction of Ki‐67 of Invasive Ductal Breast Cancer Based on Ultrasound Radiomics Nomogram
Authors: Zhu Yunpei , Dou Yanping , Qin Ling , Wang Hui , Wen Zhihong 
Published: July 2022

PurposeThe objective of this research was to develop and validate an ultrasound‐based radiomics nomogram for the pre‐operative assessment of Ki‐67 in breast cancer (BC).Materials and MethodsFrom December 2016 to December 2018, 515 patients with invasive ductal breast cancer who received two‐dimensional (2D) ultrasound and Ki‐67 examination were studied and analyzed retrospectively. The dataset was distributed at random into a training cohort (n = 360) and a test cohort (n = 155) in the ratio of 7:3. Each tumor region of interest was defined based on 2D ultrasound images and radiomics features were extracted. ANOVA, maximum correlation minimum redundancy (mRMR) algorithm, and minimum absolute shrinkage and selection operator (LASSO) were performed to pick features, and independent clinical predictors were integrated with radscore to construct the nomogram for predicting Ki‐67 index by univariate and multivariate logistic regression analysis. The performance and utility of the models were evaluated by plotting receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and calibration curves.ResultsIn the testing cohort, the area under the receiver characteristic curve (AUC) of the nomogram was 0.770 (95% confidence interval, 0.690–0.860). In both cohorts, the nomogram outperformed both the clinical model and the radiomics model (P < .05 according to the DeLong test). The analysis of DCA proved that the model has clinical utility.ConclusionsThe nomogram based on 2D ultrasound images offered an approach for predicting Ki‐67 in BC.
Characteristics of Riehl melanosis in an ethnic Asian population: A comparative study according to age, sex, and hair dye use
Authors: Choi Myoung Eun , Lim Youngkyoung , Lee Woo Jin , Won Chong Hyun , Lee Mi Woo , Chang Sung Eun 
Published: July 2022

AbstractBackgroundRiehl melanosis, characterized by diffuse brown to grey hyperpigmentation of the face and neck, affects middle‐aged women with dark skin phototypes. Riehl melanosis prevalence has increased in Korea, and a relationship with henna hair dye has been suspected. In this study, we aimed to evaluate clinical features and patch test results of Riehl melanosis patients and analyse them according to age, sex, and hair dye use.MethodsWe identified patients showing clinical and histopathological manifestations consistent with Riehl melanosis between January 2009 and December 2019 in our medical centre.ResultsOf 154 patients, 76.5% had positive patch‐test results, and the most common sensitizing agents were nickel, cobalt, and benzyl salicylate. Patients ≥50 years old were more likely to have spotty hyperpigmentation and less likely to have diffuse patterns, while lesions in the younger‐aged group were more commonly accompanied by erythema. Preceding erythema was found more often in female patients. Hair dye usage was more likely to be associated with aggravation of symptoms in females. Patients who developed Riehl melanosis after hair‐dye use more frequently had lesions on the forehead and were diagnosed an average of 14.1 months earlier as compared with other patients. Short disease duration, aggravation by hair dye (except henna), laser therapy, and longer follow‐up periods were related to good treatment responses.ConclusionsDetailed history taking regarding disease duration and aggravating factors as well as the length of the period of laser therapy can be important for the management of Riehl melanosis patients.
Serum cytokine/chemokine levels in a patient with perifolliculitis capitis abscedens et suffodiens (dissecting cellulitis) successfully treated with the tumour necrosis factor α inhibitor adalimumab
Authors: Koike Yuta , Hattori Naoko , Murota Hiroyuki 
Published: July 2022

AbstractPerifolliculitis capitis abscedens et suffodiens (PCAS), also called dissecting cellulitis, is a refractory disease characterized by deep follicular occlusion, ruptures and infections. Here, we present a case of PCAS in a young man whose scalp showed subcutaneous nodules with purulent secretions, and geographic hair loss from the occipital region. Since the PCAS was refractory to treatment by incision, drainage and systemic antibiotics, we administered adalimumab, an antitumour necrosis factor (TNF) antibody. After 4 months of treatment with adalimumab, the PCAS improved markedly, with flattening of the scalp lesions and hair regrowth. We examined the serum levels of cytokines/chemokines using a Magnetic Bead Panel Plate Assay to compare levels before and at 3 months post‐adalimumab treatment. The results showed a slight decrease in TNF‐α levels and a significant reduction in the expression of cytokines or chemokines that promote macrophage and neutrophil migration, suggesting that these factors might contribute to the pathogenesis of PCAS.
Solvent effect on activities of aryloxyl‐radical scavenging and singlet‐oxygen quenching reactions by vitamin E: Addition of water to ethanol solution
Authors: Nagaoka Shin‐ichi , Nomoto Nanaho , Tasaka Tomohiko , Nagashima Umpei , Matsumoto Takatoshi , Ohara Keishi 
Published: July 2022

AbstractSolvent effects on the activities of aryloxyl‐radical (aroxyl‐radical) scavenging and singlet‐oxygen (1O2) quenching reactions by vitamin E (α‐tocopherol) were studied with stopped‐flow and laser spectroscopies together with density functional calculations. Partial electron transfer from α‐tocopherol plays an important role in an early step of each of these antioxidant reactions. To shed light on the solvent effects, we used ethanol as the reference solvent and added water to it. The rate constant of the aryloxyl‐radical scavenging reaction by α‐tocopherol increased monotonously by adding water to the ethanol solution, because the oxidation potential of α‐tocopherol decreases as water is added. Although the rate constant of the 1O2 quenching reaction similarly increased with increasing water concentration from 0% to 10% v/v, it reached a maximum at about 10% v/v and decreased in the range 10%–20% v/v. The suppression of the 1O2 quenching in the 10%–20% v/v range could be attributed to complexes forming between 1O2 and the water molecules. On the basis of the present results, we inferred how the antioxidant activities of α‐tocopherol depend on its position in biomembranes.
Intraoperative quantitative assessment of parathyroid blood flow during total thyroidectomy using indocyanine green fluorescence imaging ‐ surgical strategies for preserving the function of parathyroid glands
Authors: Iritani Keisuke , Teshima Masanori , Shimoda Hikari , Shinomiya Hirotaka , Otsuki Naoki , Nibu Ken‐ichi 
Published: July 2022

AbstractObjectiveWe investigated the factors affecting postoperative parathyroid gland (PTG) function and devised an objective index to predict the postoperative PTG function during total thyroidectomy.MethodThis was a retrospective clinical review of 21 consecutive patients who were diagnosed with papillary thyroid carcinoma and underwent total thyroidectomy. The maximum intensity ratio (MIR) was determined as the maximum fluorescence intensity after ICG injection divided by the intensity before ICG injection.ResultsPostoperative hypoparathyroidism is significantly associated with simultaneous central neck dissection (CND) and lateral neck dissection (LND) (p = .032). The Spearman correlation test showed a moderate correlation between the MIR and iPTH levels (p = .0047). The optimal MIR cutoff value for predicting postoperative hypoparathyroidism was 2.14 with area under the curve = 0.904 (sensitivity: 0.769 and specificity: 1.00).ConclusionCND + LND was significantly associated with postoperative hypoparathyroidism. MIR was found useful in predicting the postoperative PTG function.Level of Evidence: 3b.
Short‐ and long‐term strategies for navigating research‐ambivalent organizational cultures besetting embedded researchers
Authors: Hudson Matthew F. 
Published: July 2022

AbstractMany health systems may host embedded researchers (ERs) and provide fiscal resources to encourage health service research. However, ERs may remain challenged to initiate research in these settings. This discussion examines how health system culture may impede research initiation, thereby exposing a paradox for embedded researchers immersed in research‐ambivalent health systems. The discussion ultimately describes potential short‐term and long‐term strategies embedded researchers may employ to initiate scholarly inquiry in research‐ambivalent health systems.
Consumers' identity signaling towards social groups: The effects of dissociative desire on brand prominence preferences
Authors: Raimondo Maria Antonietta , Cardamone Ernesto , Miceli Gaetano “Nino” , Bagozzi Richard P. 
Published: July 2022

AbstractThe present research addresses an area of brand behavior that is under studied to date but has important implications for national and international brands. Brand prominence, that is, the extent to which a product reveals important visible brand identifiers, plays a fundamental role in determining consumer signaling behavior towards social groups and requires accurate brand management decisions. Integrating the literatures on brand prominence and social groups, this study proposes that the presence (vs. absence) of dissociative desire towards an out‐group increases the preference for products featuring more prominent signs of a brand relevant for an in‐group. Brand self‐verification explains the relationship between dissociative desire and brand prominence preferences. Moreover, this effect disappears when the brand is used by the minority (vs. majority) of other in‐group members and the identification with the in‐group is lower. Results of two experiments and one survey support our conceptual framework and suggest that managers should use more prominent brand signs to attract consumers desiring to dissociate from relevant out‐groups. Our research thus provides implications for defining branding strategies according to consumers' identity signaling goals towards social groups, which are becoming more important as brands assume global roles in tension with consumer identities and marketing strategy.
Effects of short daylight and mild low temperature on mitochondrial degeneration in the testis of Cricetulus barabensis
Authors: Zhao Xiang‐Yu , Wang Shuo , Xu Jin‐Hui , Wang Chuan‐Li , Feng Yong‐Zhen , Xue Hui‐Liang , Wu Ming , Chen Lei , Xu Lai‐Xiang 
Published: July 2022

AbstractIn this study, we investigated the mitochondrial energy supply capacity and molecular mechanisms of apoptosis, mitochondrial fission, and mitophagy in regulating mitochondrial degeneration in testis of striped dwarf hamsters (Cricetulus barabensis) under mild low temperature (15°C) and short daylight (10 h:14 h) conditions. Results showed that under moderate daylight and mild low temperature (ML), short daylight and moderate temperature (SM), short daylight and mild low temperature (SL) conditions, the mitochondria were swollen and cristae were disrupted. Compared with the moderate daylight & moderate temperature group (MM; 12 h:12 h, 22°C), the number of mitochondria was significantly decreased in the SM and SL groups. Both short daylight and mild low temperature reduced the protein expression of citrate synthase, thus the energy supply capacity of mitochondria may be weakened. Compared with the MM group, bax/bcl2 protein expression was higher in three treatment groups, and caspase3 activity increased in SM and SL groups, suggesting that short daylight can induce apoptosis. DRP1 protein expression showed no difference in four groups, while the FIS1 protein expression was significantly decreased in three treatment groups, this indicates that short daylight and mild low temperature can increase mitochondrial fission level. PINK1 protein expression was significantly increased in ML and SL groups, indicates that mild low temperature will lead to increased mitophagy level. Generally, short daylight induced degeneration of mitochondria in the testis of hamsters mainly by increasing apoptosis, while under mild low temperature, balanced regulation of mitophagy and mitochondrial fission appear to contribute to the protection of mitochondria.
Modeling Propylene Polymerization in a Two‐Reactor System: Model Development and Parameter Estimation
Authors: Charoenpanich Thanutchoke , Anantawaraskul Siripon , Soares João B. P. , Wongmahasirikun Phonpimon , Shiohara Supawadee 
Published: July 2022

AbstractA series of two reactors is commonly used to produce commercial polypropylene resins to make products with a broad range of microstructures using different feeding policies and/or operating conditions in both reactors. A mathematical model describing the molecular weight distribution (MWD) and yield of polypropylene made with a Ziegler–Natta catalyst in a two‐reactor system is developed in this work. A new methodology to estimate the polymerization kinetic parameters combining the simultaneous MWD deconvolution and analysis of polymer yields in both reactors is also proposed. This pragmatic approach can be applied without knowledge of detailed polymerization rates and is, therefore, very convenient to quantify polymerizations in continuous pilot and/or commercial reactors, where such information is generally not available.
Temporal Population Trends and Habitat Associations for Mountain Whitefish in Central Idaho
Authors: Roth Curtis J. , Meyer Kevin A. , Roberts Ronald V. , Lipple Brock A. , Stark Eric J. , Copeland Timothy 
Published: July 2022

Abstract
Mountain Whitefish Prosopium williamsoni have failed to garner the same level of attention as other members of the salmonid family in terms of scientific investigations, especially with regard to habitat associations and population status. Consequently, we used snorkel survey data from 1985 to 2019 to relate a suite of environmental factors to Mountain Whitefish occupancy and abundance and to estimate population growth rates in central Idaho. Mountain Whitefish population growth rates in the majority of subbasins in central Idaho appear to be stable or increasing over the past several decades, but more so in the Salmon River basin than in the Clearwater River basin. Mountain Whitefish occupancy and abundance were higher in stream reaches that were lower in elevation and gradient and larger in size, with an occupancy rate of &lt;0.10 in stream reaches that were &lt;6 m average wetted width but &gt;0.50 in stream reaches that were ≥9 m average wetted width. Road density was positively associated with the occupancy and abundance of Mountain Whitefish, contrasting previous studies that generally report negative associations between road density and salmonid population metrics. While this relationship may simply be correlative in nature, in the relatively sterile lotic environment of central Idaho, such anthropogenic disturbance may inadvertently result in nutrient enrichment, potentially benefitting the forage base of Mountain Whitefish. We also observed that conductivity positively influenced Mountain Whitefish abundance, likely stemming from its direct effect on stream productivity. Although the status of Mountain Whitefish in central Idaho appears generally stable, the paucity of studies reporting on the status of this species highlights the need for additional research devoted to a better understanding of trends in Mountain Whitefish abundance across their range.