bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of synbiotics in improving inflammatory status in nasopharyngeal carcinoma patients
Authors: Fasitasari Minidian , Subagio Hertanto Wahyu , Suprihati Suprihati 
Published: June 2022

Abstract
Nasopharyngeal carcinoma (NPC) is a malignant tumor that grows from the epithelial cells of nasopharynx. NPC has the ability to modify its metabolism and leads the patient to suffer from malnutrition and cachexia, therefore aggravates the occurrence of impaired inflammatory response. Currently, available treatments for NPC are chemotherapy, radiotherapy, or chemoradiotherapy. Despite of its efficacy, these regimens have been known to elicit various inflammation-related side effects including infection, diarrhea, and mucositis. It has long been established that increased activity of inflammatory response is associated to low survival rate in both early and advanced stage of cancer. Furthermore, uncontrolled and dysregulated inflammatory response are significantly correlated with malignant progression of cancer. Considering how pivotal inflammation to malignancy progression, there is a need for effective strategies to modulate inflammatory response. Various strategies have been proposed to improve immune response in NPC patients including dietary supplementation of synbiotics. Synbiotics refers to the manipulation of both probiotics and prebiotics to provide a synergistic benefit to the host by promoting the growth of beneficial bacteria while inhibiting the growth of pathogenic bacteria. There is a growing number of evidences related to the potential of synbiotics in modulating the pro-inflammatory response and improve immune systems in a variety of conditions, including cancer. In this study, we will discuss the immunomodulatory effects of synbiotics in the nasopharyngeal carcinoma occurrences.
Utilization of serial tendering to reduce the value project
Authors: Mohammed Arshed Abbas , Erzaij Kadhim Raheim 
Published: June 2022

Abstract
Serial tendering is better than other types of tendering when it comes to cost reduction, where civil infrastructure projects need a significant increase in the amount of tough planning, financial expenditures, engineering work, and resources of a different character than other types of construction projects. The effects of a lack of funding cause decrease in the completion speed of the project on time. The need to reduce the cost of bidding on recurrent civil infrastructure projects is critical. To achieve the desired goals of this research, this article will provide an overview of the type of bids used in the construction of schools implemented in the current financial perspective in Iraq, the extent of benefit, and the amount of possible reduction if continuous and serial tendering are used.
Local aromatase excess with recruitment of unusual promoters of CYP19A1 gene in prepubertal patients with gynecomastia
Authors: Deberles Emilie , Durand Isabelle , Mittre Hervé , Reznik Yves , Morera Julia 
Published: June 2022

Abstract

Objectives
Gynecomastia may be due to aromatase excess in several diseases such as obesity and cancer. Aromatase excess syndrome (AEXS) is an autosomal dominant disorder caused by overexpression of CYP19A1. Germinal mutations occurring in AEXS include various genomic rearrangements including duplication, deletion, and inversion identified in the upstream region of CYP19A1. Aromatase overexpression caused by a CYP19A1 somatic mutation has been rarely described.

Methods
Breast adipose tissue biopsies or surgical specimens were obtained from 19 subjects with gynecomastia. Aromatase quantification was performed by digital PCR and CYP19A1 sequencing by RACE PCR products.

Results
We observed localized aromatase overexpression (>10 fold greater than normal) in breast adipose tissue from three prepubertal males with gynecomastia out of the 19 cases. One carried a chromosomal rearrangement between CYP19A1 and DMXL2, consistent with AEXS. In the 2 others, the first exon of CYP19A1 contained 11 different tissue-specific promoter subtypes, specifically I.4 or I.3 normally expressed by adipose tissue, but also the placental I.2 promoter and the more ubiquitous I.7 which is usually expressed in breast cancer, uterine, and endothelial tissues. No differences in clinical or biochemical characteristics were observed between these 3 subjects and 16 others without aromatase overexpression.

Conclusions
We describe two cases of aromatase overexpression in breast adipose tissue associated with nonspecific promoter recruitment. Further investigations are necessary to understand the mechanisms involved in aberrant promoter selection.
Clinical profile and aetiologies of delayed puberty: a 15 years’ experience from a tertiary centre in Sudan
Authors: Galal Marwa S. , Musa Salwa A. , Babiker Omer O. , Hamdan Hamdan Z. , Abdullah Mohamed A. 
Published: June 2022

Abstract

Objectives
Delayed puberty is a common presentation to endocrine clinics, with adult height, sexual capability and fertility being the main concerns for the child and his/her family. Presentation is variable including short stature and/or absence of secondary sexual characteristics. The aetiology can either be constitutional, functional or permanent hypogonadotropic hypogonadism, permanent hypergonadotropic hypogonadism or unclassified. Despite the importance of this subject, there are no publications from Sudan.

Methods
A retrospective hospital-based study. Records of all patients who were seen in the endocrinology unit at Gaffar Ibn Auf Children’s Hospital and were diagnosed as having delayed puberty were reviewed and demographic, clinical, and investigations data were obtained.

Results
A total of 136 patients were included in this study. Presentation includes short stature in 52.2%, both short stature and delayed puberty in 27.2%, and delayed puberty in 20.6%. The most common aetiologies were permanent hypogonadotropic hypogonadism and functional hypogonadotropic hypogonadism presented in 37.5% and 36% respectively, while constitutional delay of growth and puberty was found in only 14.7%. Type 1 diabetes mellitus (T1DM) was the most frequent chronic illness followed by coeliac disease. Hypergonadotropic hypogonadism was diagnosed in 11.7%, the majority of which were females.

Conclusions
The aetiological pattern reported in this series highlights the role of nutrition and general well-being in pubertal development, as well as the major impact of genetics and consanguinity on disease patterns. Data from African countries are limited and this is the first reported cohort on delayed puberty from Sudan.
Penser le « changement » à l’envers : le passé, la tradition et les ancêtres vus par les différentes générations de l’époque classique
Authors: Bartzoka Alexandra 
Published: June 2022

RésuméLa présente étude aborde la notion de « changement » dans le cadre de la cité grecque de l’époque classique, mais du côté opposé, celui de la continuité historique. Pour ce faire, elle examine les mots et expressions désignant le passé ancestral d’un peuple : elle étudie les significations du termepatrioset des termes apparentés dans la littérature grecque des Veet IVesiècles (Hérodote, Thucydide, Xénophon, Aristophane, Aristote, orateurs attiques), présente le cadre politique dans lequel les générations qui vivent à l’époque classique font appel à leurs ancêtres et recherche, enfin, les éléments qui construisent l’identité de la cité classique. D’abord, il en ressort que les notions d’« ancestral » et de « traditionnel » sont floues et que leur connotation dépend des individus qui en font usage, ainsi que du moment historique dans lequel vivent les intéressés. Ensuite, il apparaît qu’elles sont le moyen qui permet aux Anciens d’exprimer leur réaction – positive ou négative – face aux transformations multiples que subissent les sociétés classiques.
The Drafting Committee of theSC de Ludis Saecularibusof 17 February 17 BCE and the Principle of Seniority-based Hierarchy in Official Documents
Authors: Pina Polo Francisco 
Published: June 2022

SummaryThe fragmentary inscription on theludi saecularescontains mention of twosenatus consultaof year 17 BCE. This paper gives new arguments for identifying the five known consulars heading the drafting commission of thesenatus consultumof 17 February: M. Iunius Silanus (cos. 25), Cn. Cornelius Lentulus (cos. 18), L. Marcius Censorinus (cos. 39), C. Asinius Pollio (cos. 40) and L. Vinicius (cos. suff. 33). This list challenges the accepted notion that senators named as members of the drafting commissions ofsenatus consulta(and other official documents) were always arranged according to their seniority (i.e., who had held a given office earliest). Such an open new approach could question or even significantly alter the chronology of Roman magistracies that has been accepted on the basis of seniority hierarchy so far.
The Mixed Constitution of Demetrius Phalereus
Authors: Saldutti Vittorio 
Published: June 2022

SummaryThe politeia established in Athens in 317 after a covenant between Cassander and Demetrius of Phalerum was variously described by ancient authors as a tyranny, an oligarchy, and a democracy. Even among modern scholars there is no agreement about its definition. A close study of the architecture of the so-called regime of Demetrius and a comparison with the almost contemporary constitution of Cyrene, imposed on the African town by Ptolemaeus I, lead us to characterize it as a mixed constitution, which balanced elements from the three principal types of political organisation. This experiment had a strong impact on the Hellenistic and Roman political traditions, as testified by Cicero, who recalled Demetrius as the last great Athenian lawgiver and inventor of the blended constitution.
Berenike Phernophoros and Other Virgin Queens in Early-Ptolemaic Egypt
Authors: Coşkun Altay 
Published: June 2022

SummaryThe main function of Hellenistic queenship is increasingly understood as contributing to the definition of thebasileus. The early Ptolemies produced the most peculiar version of the ‘sister queen’, known throughout the Near East as an ideological construct, but taken literally in Egypt from the time of Ptolemy II Philadelphos (285/282–246) and Arsinoe II Philadelphos (278/275–270), the ‘Sibling-Lovers’. The most famous example of a ‘virgin queen’ is Berenike, the daughter of Ptolemy III Euergetes and Berenike II, best known from the Kanopos Decree, which regulated her posthumous cult (238). Often understood as a merely honorary title for some or potentially all princesses in Alexandria, thebasilissatitle of unmarried girls has found little scholarly attention so far. Altogether, there are surprisingly few royal daughters for whom we have clear evidence: besides the aforesaid Berenike, her sister Arsinoe III (died 204) and previously Berenike (later known as Phernophoros, died 246), the daughter of the Philadelphoi. Claims that Arsinoe II or her sister Philotera had enjoyed the same status at the court of Ptolemy I Soter (323–282) cannot be substantiated, so that theirbasilissatitles should be explained by marriage with a king. The phenomenon of virgin queenship was thus of limited duration. It is best interpreted as a ramification of an emphatically endogamous royal dynasty: Ptolemy II and Ptolemy III pledged their most distinguished daughter to the future successor even before he had been chosen from among his brothers.
Wear resistance and microstructural evaluation of a hardfacing welded S355J2 steel pipe piles
Authors: Özen Fatih , Onar Volkan , Çil Gökhan , Gel Mahmut 
Published: June 2022

Abstract
Steel pipe piles are used to reinforce the grounds. Due to high hardness of the rocky materials, in some cases, the tip surface should be developed with new designs in terms of geometry, material and heat treatment. In this study, a hardfacing welding, which reinforces the application point of the tip surface, was applied on the steel pipe pile shoe tip which was manufactured from S355J2 steel. Wear tests were applied and hardness measurements were made to explain wear behavior. According to the results, the hardened surface of the 3rd layer which was welded with FCH-360 flux cored wire showed higher hardness than other layers. Similarly, the highest wear resistance was obtained in this layer. Martensitic and bainitic structures with ferrite islets were observed from the first layer to the second layer. The bainite and ferrite isles were gradually transformed to martensite and maintained itself from first to third layer. The martensitic structure mainly controlled the hardness and wear resistance. The sizes of the martensite highly affected the hardness and wear resistance of the layer itself.
Effect of tempering temperature on mechanical properties and microstructure of AISI 4140 and AISI 4340 tempered steels
Authors: Saraç Erdem , Özbek Nursel Altan 
Published: June 2022

Abstract
The AISI 4140 and AISI 4340 tempered steels are widely used in industry. This study investigated the effects of the tempering temperature on the mechanical properties of these steels. The steels were kept at 850 °C for 30 min, left in an oil environment, and then subjected to hardening. The samples were then tempered for 1 h at four different temperatures (300, 450, 550, and 650 °C). Hardness measurements were performed to determine the mechanical properties of the materials. In addition, the samples were subjected to tensile, notch impact, and wear tests. The samples were also examined microstructurally. The results revealed that the hardness, impact energy, and wear rates of samples of both steels decreased when tempering was applied after quenching. As the tempering temperature was increased, these values tended to decrease. However, the impact value increased in parallel with the tempering heat treatment and tempering temperature.
Study on the effects of the tension and torsion loading sequence on the mechanical properties of a 20 carbon steel
Authors: Hou Pengliang , Jing Huantao , He Yujie , Zhao Hongwei , Xiao Haining , Zhang Chunwei 
Published: June 2022

Abstract
In engineering applications, cylindrical bars of 20 carbon steel are often subjected to a combination of tensile loading and torsional loading during the service, thereby causing premature failure or an accident. In order to explore the influence of loading sequence of tension and torsion on the mechanical properties of 20 carbon steel, tests of combined tension-torsion loading and combined torsion-tension loading are employed in this work. During experiments, a microscope is used for the in situ characterization of micro-damage evolution on the surface of specimens. At the same time, to analyze the influence of loading sequence on the stress distribution, ABAQUS software is utilized to conduct the relevant finite element simulation, where the results of finite element analysis are consistent with the experiments. Evidently, the torsional strength of 20 carbon steel is decreased with an increase in the pre-tensile stress, under the combined tension-torsion. However, the tensile strength of 20 carbon steel is enhanced with the increasing pre-torsional angles, under the combined torsion-tension. Moreover, the in situ images characterized the micro-damage evolution of 20 carbon steel under pure tension, pure torsion, combined tension-torsion and combined torsion-tension. It is concluded that the deference in loading sequence changes the failure mechanism of 20 carbon steel is different.
The Anxiety of Tradition: Unrealized Weddings in Berdichevsky’s Yiddish Stories
Authors: Redfield James Adam , Gutfeld Tamar 
Published: June 2022

Abstract
The trilingual author Mikhah Yosef Berdichevsky (1865–1921) is widely known as a literary modernist and a rebel against Jewish socio-religious conventions. Yet he also developed an original dialectical way of thinking about Jewish tradition. Berdichevsky’s theory of tradition is partly elaborated in his undeservedly obscure Yiddish stories. In order to reconstruct this theory, we undertake a typology and thematic analysis of their signature literary trope: the unrealized wedding.
On Truth and Lie in the Object-Oriented Sense
Authors: Harman Graham 
Published: June 2022

AbstractThis article begins with a treatment of Friedrich Nietzsche’s early essay “On Truth and Lie in the Extra-Moral Sense.” The essay is often read, in the deconstructive tradition, as a showcase example of the impossibility of making a literal philosophical claim: is Nietzsche’s claim that all truth is merely metaphorical itself a true statement, or merely a metaphorical one? The present article claims that this supposed paradox relies on the groundless assumption that all philosophy must ultimately be grounded in some unshakeable literal truth. From here, we turn to Edmund Gettier’s famous critique of the widespread notion of knowledge as “justified true belief.” Expanding on Gettier’s point, it is argued that there can only be “justified untrue belief” or “unjustified true belief,” never a belief that is both justified and true at once.
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in multimodal therapy for patients with oligometastatic peritoneal gastric cancer: a randomized multicenter phase III trial PIPAC VEROne
Authors: Casella Francesco , Bencivenga Maria , Rosati Riccardo , Fumagalli Uberto Romario , Marrelli Daniele , Pacelli Fabio , Macrì Antonio , Donini Annibale , Torroni Lorena , Pavarana Michele , De Manzoni Giovanni 
Published: June 2022

Abstract

Objectives
Peritoneal carcinomatosis is the most frequent site of metastases in patients with gastric cancer. Current standard treatment is palliative systemic chemotherapy with very poor prognosis. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) resulted in long-term benefits in selected patients. Among patients with peritoneal carcinomatosis, a distinctive subset is oligometastatic disease which is characterized by low metastatic burden. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a recent technique of intraperitoneal chemotherapy used in combination with systemic chemotherapy with promising results.

Methods
PIPAC VER-One is a prospective, randomized, multicenter phase III clinical trial that aims to evaluate the effectiveness of the use of PIPAC in combination with systemic chemotherapy in patients with gastric cancer and synchronous positive peritoneal cytology and/or limited peritoneal metastases (peritoneal cancer index [PCI] ≤6). Patients will be randomized into two arms: arm A (control) treated with standard systemic chemotherapy and arm B (experimental) treated with a bidirectional scheme including PIPAC and systemic chemotherapy.

Results
Primary endpoint is the secondary resectability rate. Secondary endpoints are: overall survival (OS), pregression-free survival (PFS), disease-free survival (DFS), histological response assessed both on primary tumor and peritoneal lesions, quality of life (QoL), complication rate (CTCAE v5), and incremental cost-effectiveness ratios (ICER).

Conclusions
The role of PIPAC in multimodal treatment for oligometastatic gastric cancer will be investigated in this trial.
A patient with hereditary transthyretin amyloidosis involving multiple cranial nerves due to a rare p.(Phe84Ser) variant
Authors: Yan Xian-rang , Hong Ming-fan , Zhou Zhi-hua , Liu Ai-qun , Peng Zhong-xing , Wu Wei-feng , Jing Cheng , Lin Jia-xiu , Long Ying , Yu Qing-yun 
Published: June 2022

Abstract
We report a 30-year-old man involving gastrointestinal symptoms, vitreous opacity, and multiple cranial neuropathies. Transthyretin-related hereditary amyloidosis genetic testing revealed a rare c.251T > C variant p.(Phe84Ser). Only four cases with this variant have been reported before.
Optimierte Antriebs- und Sensorauslegung für intelligente Vorschubachssysteme
Authors: Herfs Werner , Kehne Sebastian , Neus Stephan 
Published: June 2022

Abstract
Moderne Vorschubachssysteme benötigen eine gute Beobacht- und Steuerbarkeit des Tool-Center-Punktes (TCP), um auch bei größeren Prozesskräften passgenau fertigen und den Prozess monitoren zu können. Hierbei ist es vorteilhaft, dies schon bei der Auslegung des Antriebsstranges und bei der Wahl der Sensorik zu berücksichtigen. Klassische Kriterien für Beobacht- und Steuerbarkeit haben sich in der Praxis als weniger geeignet herausgestellt, weswegen neue Kriterien im Rahmen eines DFG-Forschungsprojekt in dieser Veröffentlichung entwickelt werden.
Machine-Learning-Ansatz zur Produktionsauftragsplanung
Authors: Mielke Jonas , Winkler Herwig 
Published: June 2022

Abstract
Maschinelle Lernalgorithmen sind leistungsstarke Werkzeuge, um Muster und Wechselwirkungen in Datenstrukturen zu erkennen. Diese Fähigkeiten werden im Rahmen dieses Beitrags zur Optimierung der Auftragsplanung eines Produktionssystems genutzt. Dabei wird ein praxisnahes Vorgehen zur schnellen Evaluierung neuer Auftragssituationen vorgestellt. Die Datengrundlage bildet dabei ein Simulationsmodell eines realen Produktionssystems.
Produktion der Zukunft – Reifegradmodell als Analyseinstrument
Authors: Wessing Simon , Müller Eckehard 
Published: June 2022

AbstractZur Gestaltung von Wertschöpfungsprozessen oder Fabrikplanungen ist für Unternehmen der aktuelle Umsetzungsgrad im Hinblick auf Industrie 4.0, Digitalisierung oder Nachhaltigkeit von großer Bedeutung. In diesem Beitrag werden schwerpunktmäßig Produktionsprozesse bzw. -systeme analysiert und die Ergebnisse in einem Säulenmodell mit dem Titel „Produktion der Zukunft“ definiert. Dieses besteht aus neun Bereichen und wird durch den Zusatz „LAND“ (lean, automatisiert, nachhaltig und digital) beschrieben. Zur Messung der aktuellen Implementierung wird ein Reifegradmodell mit fünf Stufen entwickelt. Für Unternehmen gibt das Ergebnis des Modells die Möglichkeit, ihre Stärken und Schwächen hinsichtlich Themen der Produktion der Zukunft festzustellen.
Sex Differences in Performance and Depth of Field in the United States Olympic Trials
Authors: Jobe Tyler K. , Shaffer Hali N. , Doci Colleen L. , Gries Kevin J. 
Published: June 2022

Abstract
Jobe, TK, Shaffer, HN, Doci, CL, and Gries, KJ. Sex differences in performance and depth of field in the United States Olympic trials. J Strength Cond Res 36(11): 3122–3129, 2022—Recently, there has been an increased discussion on the role of sex as a variable in human performance. Although there likely remains sociological factors, we can estimate biological sex differences in human performance by comparing finishing times in elite men and women. We sought to determine the effect of sex on running and swimming velocity and depth of field in events of varying lengths in the previous 25 years. Finishing times from United States Olympic trials in running events (100 m to marathon) and freestyle swimming (50–1,500 m) from 1996 to 2021 were collected. Sex differences in velocity were calculated for each year (trends), place (first through seventh), and depth of field (nth place/first place). Significance was set at p ≤ 0.05. Men were 9–13% faster than women in all running events (p ≤ 0.05). The 100-m dash (9%) had the lowest sex difference compared with races of longer distance (p ≤ 0.05). In swimming, men were faster in all events (6–12%, p ≤ 0.05), in which sex differences generally decreased with longer distances. Depth of field was similar between men and women in all running and swimming events. No differences in the analyzed variables were observed from 1996 to 2021. These data suggest that elite men are 9% faster in the 100 m compared with running races of longer distances (~12%). Sex differences in swimmers tended to get smaller as duration increased. Although participation and other sociological factors in these events may play a role, these sex differences warrant further discussion on the role of sex in athletic competition.