bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the antimicrobial-impregnated peripherally inserted central catheter decrease the CLABSI rate in neonates? Results from a retrospective cohort study
Authors: Bayoumi Mohammad A. A. , van Rens Matheus F. P. T. , Chandra Prem , Masry Alaa , D’Souza Sunitha , Khalil Amr M. , Shadad Afaf , Alsayigh Safaa , Masri Razan M. , Shyam Sunitha , Alobaidan Fatima , Elmalik Einas E. 
Published: November 2022

BackgroundThe use of antimicrobial-impregnated peripherally inserted central catheters (PICCs) has been introduced in the last few years to neonatal units aiming to reduce central line-associated bloodstream infection (CLABSI).MethodsThis retrospective observational study aimed to compare the CLABSI rates and other catheter-related parameters including the insertion success rates and catheter-related complications in the antimicrobial-impregnated and conventional (ordinary) PICCs in NICU between 2017 and 2020.ResultsOur dedicated PICC team including physicians and nurses inserted 1,242 conventional (PremiCath and NutriLine) and 791 antimicrobial-impregnated PICCs (PremiStar) over the study period from 2017 to 2020. Of those 1,242 conventional PICCs, 1,171 (94.3%) were 1 Fr single lumen and only 71 (5.7%) were 2 Fr double lumen. The mean ± SD [median (IQR)] for the birth weight in all babies who had a PICC line was 1,343.3 ± 686.75 [1,200 (900, 1,500)] g, while the mean ± SD for the gestational age was 29.6 ± 4.03 [29 (27, 31)] weeks. The mean ± SD [median (IQR)] age at the time of insertion for all catheters was 9.3 ± 21.47 [2 (1, 9)] days, while the mean ± SD [median (IQR)] dwell time was 15.7 ± 14.03 [12 (8, 17)] days. The overall success rate of the PICC insertion is 1,815/2,033 (89.3%), while the first attempt success rate is 1,290/2,033 (63.5%). The mean ± SD [median (IQR)] gestational age, birth weight, age at catheter insertion, and catheter dwell time were 28.8 ± 3.24 [29, (26, 31)] weeks, 1,192.1 ± 410.3 [1,150, (900, 1,450)] g, 6.3 ± 10.85 [2, (1, 8)] days, and 17.73 ± 17.532 [13, (9, 18)] days in the antimicrobial-impregnated catheter compared with 30.1 ± 4.39 [29, (27, 32)] weeks (P &lt; 0.001), 1,439.5 ± 800.8 [1,240, (920, 1,520)] g (P &lt; 0.001), 11.1 ± 25.9 [1, (1, 9)] days (P &lt; 0.001), and 14.30 ± 10.964 [12, (8, 17)] days (P &lt; 0.001), respectively, in the conventional PICCs. The use of the antimicrobial-impregnated catheter was not associated with any significant reduction in the CLABSI rate (per 1,000 days dwell time), either the overall [P = 0.11, risk ratio (RR) (95% CI): 0.60 (0.32, 1.13)] or the yearly CLABSI rates.ConclusionsThe use of miconazole and rifampicin-impregnated PICCs did not reduce the CLABSI rate in neonates compared with conventional PICCs. However, it has a higher overall rate of elective removal after completion of therapy and less extravasation/infiltration, occlusion, and phlebitis compared with the conventional PICCs. Further large RCTs are recommended to enrich the current paucity of evidence and to reduce the risk of bias. Neonatal PICCs impregnation by other antimicrobials is a recommendation for vascular access device manufacturers.
Investigation of the allergens in 2,316 children with allergic rhinitis from Guangdong, China
Authors: Zhang Nannan , Wu Yunwen , Wei Zequn , Li Jinen , Shi Jiao , Cai Rong , Huang Hailing , Ouyang Siyuan , Zhang Qingfeng 
Published: November 2022

Allergic rhinitis (AR) is one of the popular childhood diseases, bringing physical and metal burdens to the children and their families. The study was performed to detect common allergens eliciting AR in children, to investigate the prevalence of allergens in different age and gender cohorts, and to provide a reliable basis for clinical prevention and treatment of AR during childhood. We measured serum-specific IgE and performed inhalant and ingestion allergen examinations in 2,316 children with AR, in collaboration with BioSciTec GmbH. The prevalence of different allergens was determined according to gender, age, severity, and season. Among the 2,316 AR cases, the top five inhalant allergens were Dermatophagoides pteronyssinus (1,674 cases, 72.3%), Dermatophagoides farinae (1,520 cases, 65.6%), Blomia tropicalis (1,477 cases, 63.8%), Cockroach (602 cases, 26.0%), and Dog hair (602 cases, 26.0%). The top five ingestive allergens were Milk (1,111 cases, 48.0%), Egg white (543 cases, 23.4%), Shrimp/Crab (425 cases, 18.4%), Beef/Mutton (422 cases, 18.2%), and Egg yold (329 cases, 14.2%). AR severity analyses showed that 50.9% (1,180 cases) of D. pteronyssinus allergies were above level three, 47.9% (1,109 cases) of D. farinae allergies were above level three, only 23.3% (539 cases) of B. tropicalis allergies were level three, and B. tropicalis allergies were mainly of level 2. Other AR-inducing allergens mainly produced level one or two reactions. Regarding ingestion allergens, 7.9% (183 cases) of milk allergies and 4.7% (108 cases) of Shrimp/Crab allergies were above level three, and other allergens induced AR mainly of level one or two. The study investigated the major allergens eliciting AR in children from Guangdong, China, assessed the prevalence and severity among cohorts regarding age, gender, and season, and produced essential information on childhood AR, laying important references for AR prevention and treatment in the future.
Parents' intentions toward preschool children's myopia preventive behaviors: Combining the health belief model and the theory of planned behavior
Authors: Jiang Nan , Chen Jiayue , Cao He , Liu Yongyi , Zhang Yuxin , Wang Quqin , Wang Ting , Zhao Huilan , Lu Hui , Yang Lei , Wang Jiwei 
Published: November 2022

ObjectiveThis study aimed to develop an integrated model based on the health belief model (HBM) and the theory of planned behavior (TPB) to explore the influencing factors of parents' intentions toward preschool children's myopia preventive behaviors.MethodsThis cross-sectional study was conducted in Minhang District, Shanghai, China in January 2022. One thousand six hundred and twenty-eight parents of preschool children from seven preschools were recruited in the study. A four-part questionnaire was used to collect data on socio-demographic characteristics, HBM variables, TPB variables and parental intentions. This study used exploratory factor analysis to analyze HBM and TPB items. Hierarchical multiple regression analysis was performed to explore the relationship between independent variables and parents' intentions toward preschool children's myopia preventive behaviors.ResultsThe final integrative model showed that perceived severity, perceived barriers, attitudes, subjective norms, and perceived behavioral control were associated with parents' intentions toward preschool children's myopia preventive behaviors. In model 1, Child's age was entered as a control variable and explained 0.6% of the variance (F = 7.241, p = 0.007). When the HBM variables were entered in model 2, the proportion of variance increased to 25.4% (F = 73.290, P &lt; 0.001). In model 3, TPB variables were entered and explained 63.2% of the variance (F = 246.076, p &lt; 0.001).ConclusionThe integrated model of HBM and TPB constructed in this study significantly improved the degree of explanation of parents' intentions toward preschool children's myopia preventive behaviors. Parents' perceived severity, perceived barriers, attitudes, subjective norms, and perceived behavioral control can be prioritized intervention targets for myopia preventive practices in preschool children.
The evolution of mental health related policies in China: A bibliometric analysis, 1987–2020
Authors: Li Haiyan , Zhou Qingyu , Zhu Hao , Shi Peiwu , Shen Qunhong , Zhang Zhaoyang , Chen Zheng , Pu Chuan , Xu Lingzhong , Hu Zhi , Ma Anning , Gong Zhaohui , Xu Tianqiang , Wang Panshi , Wang Hua , Hao Chao , Li Chengyue , Hao Mo 
Published: November 2022

BackgroundSince 1987, the Chinese government has promoted public mental health by continuously implementing mental health related policies. This research attempts to reveal the distribution and characteristics of mental health related policies. In addition, it can help stakeholders evaluate whether the environment for policy implementation has improved and identify key points in the development of the overall mental health system.MethodsWe used a bibliometric approach to analyze the evolution of mental health related policies in China from 1987 to 2020. A total of 239 mental health related policies were collected from Beida Fabao and official Internet websites of governmental departments. Co-wording, social networks, and citation analysis were applied to explore the evolutionary features of such policies.ResultsThe evolution of policy development showed that the number of mental health related policies in China has been increasing and their content has been enriched. Over time, mental health related policies not only gradually expanded its focus on common mental disorders, but also included an increasing number of keywords related to service provision, organization and administration. However, most policies were implemented independently by separate agencies and the number of policies jointly implemented by different agencies only accounted for 32.64% of all the policies implemented. The Ministry of Health (MOH) is at the core of the collaborative network associated with implementing mental health related policies in China.ConclusionThe environment associated with the implementation of mental health related policies in China is gradually improving. However, cross-sector collaboration among different agencies needs to be strengthened and financial support for related resources needs more attention. A clear division of responsibilities among various agencies and a sustainable financing mechanism are essential to the development and implementation of mental health related policies.
Systematic review and meta-analysis of the growth performance and carcass composition of Nile tilapia (Oreochromis niloticus) fed dietary copra meal
Authors: Magbanua Tzodoq Obrero , Ragaza Janice Alano 
Published: November 2022

IntroductionNile tilapia (Oreochromis niloticus) is one of the most cultured species in the aquaculture industry. However, its market price is affected by the increasing cost of fishmeal. Plant-based proteins are being used to mitigate the problem.MethodologyThis paper comprehensively quantified the growth performance and carcass composition of Nile tilapia fed copra mealviasystematic review and meta-analysis. The literature review and paper selection were done based on the preferred reporting items for systematic reviews and meta-analysis method. The data from peer-reviewed papers that qualified from the inclusion screening criteria such as standard error reporting, feeding period, absence of dietary supplements, tilapia development stage, and crude protein levels were subjected to meta-analysis.ResultsResults showed that growth and feed utilization parameters were significantly different (P≤ 0.05), favoring the control over the plant-based diets. Moreover, the pooled estimate of carcass composition of fish fed copra meal-based diet was not significantly different with that of fish fed fishmeal-based diet (P&gt; 0.05) except for ash content (P&lt; 0.05). The feeding period, crude protein level, fish development stage, and dietary copra inclusions were subjected to meta-regression analysis due to high and statistically significant I2values to determine the sources of heterogeneity. The residual I2values showed that these factors did not affect the heterogeneity of the data presented for copra meal. These effects may be attributed to the nutritional quality of raw materials and other abiotic factors like feed preparation.ConclusionNonetheless, data from meta-analysis using model coefficients revealed that the minimum required levels are 594, 617, and 462 g kg−1of dietary copra meal are needed for optimum growth performance, feed utilization, and carcass composition of Nile tilapia, respectively. The study showed that systematic review and meta-analysis can be a useful tool in optimizing plant-based diets for aquaculture species.
Impact of multi-drug resistance on clinical outcomes of dogs with corneal ulcers infected with Staphylococcus pseudintermedius
Authors: Mauer Ashley N. , Allbaugh Rachel A. , Kreuder Amanda J. , Sebbag Lionel 
Published: November 2022

ObjectiveCompare characteristics and clinical outcomes of dogs with infectious keratitis from Staphylococcus pseudintermedius considered to be multidrug-resistant (MDR) or not.ProceduresStaphylococcus pseudintermedius isolated as the primary pathogen from canine patients with ulcerative keratitis were considered MDR if resistant to at least one agent in three or more classes of antibiotics. Medical records were reviewed for history, patients' characteristics, clinical appearance, therapeutic interventions, and clinical outcomes.ResultsTwenty-eight dogs (28 eyes) were included. Compared to non-MDR cases, MDR diagnosis was significantly more common in dogs with recent (≤30 days) anesthesia (7/15 vs. 1/13, P = 0.038) and more common in non-brachycephalic dogs (8/15 vs. 2/13, P = 0.055). Clinical appearance (ulcer size/depth, anterior chamber reaction, etc.) did not differ significantly between groups (P ≥ 0.055). Median (range) time to re-epithelialization was longer in MDR vs. non-MDR eyes [29 (10–47) vs. 22 (7–42) days] but the difference was not significant (P = 0.301). Follow-up time was significantly longer in dogs with MDR keratitis [47 (29–590) vs. 29 (13–148) days, P = 0.009]. No other significant differences were noted between MDR and non-MDR eyes in regard to time for ulcer stabilization [4 (1–17) days vs. 4 (1–12), P = 0.699], number of eyes requiring surgical stabilization (7/15 vs. 7/13, P = 0.246) or enucleation (1/15 vs. 2/13, P = 1.000), success in maintaining globe (14/15 vs. 11/13, P = 0.583) or success in maintaining vision (12/15 vs. 10/13, P = 1.000).ConclusionsMDR infections may prolong corneal healing time but did not appear to affect overall clinical outcomes in dogs with bacterial keratitis. Further research is warranted in a larger canine population and other bacterial species.
Patterns of mortality in domesticated ruminants in Ethiopia
Authors: Innocent Giles T. , Vance Ciara , Ewing David A. , McKendrick Iain J. , Hailemariam Solomon , Nwankpa Veronica R. , Allan Fiona K. , Schnier Christian , Peters Andrew R. 
Published: November 2022

BackgroundPremature death of livestock is a problem in all ruminant production systems. While the number of premature ruminant deaths in a country is a reasonable indicator for the nation's health, few data sources exist in a country like Ethiopia that can be used to generate valid estimates. The present study aimed to establish if three different data sets, each with imperfect information on ruminant mortality, including abortions, could be combined into improved estimates of nationwide mortality in Ethiopia.MethodsWe combined information from a recent survey of ruminant mortality with information from the Living Standards Measurement Study and the Disease Outbreak and Vaccination Reporting dataset. Generalized linear mixed and hurdle models were used for data analysis, with results summarized using predicted outcomes.ResultsAnalyses indicated that most herds experienced zero mortality and reproductive losses, with rare occasions of larger losses. Diseases causing deaths varied greatly both geographically and over time. There was little agreement between the different datasets. While the models aid the understanding of patterns of mortality and reproductive losses, the degree of variation observed limited the predictive scope.ConclusionsThe models revealed some insight into why mortality rates are variable over time and are therefore less useful in measuring production or health status, and it is suggested that alternative measures of productivity, such as number of offspring raised to 1 year old per dam, would be more stable over time and likely more indicative.
Dinebra retroflexa Herbal Phytotherapy: A Simulation Study Based on Bleomycin-Induced Pulmonary Fibrosis Retraction Potential in Swiss Albino Rats
Authors: El-Hela Atef A. , Hegazy Mostafa M. , Abbass Hatem S. , Ahmed Amal H. , Bakr Marwa S. Abu , Elkousy Rawah H. , Ibrahim Adel Ehab , El Deeb Sami , Sayed Ossama M. , Gad Enas S. 
Published: November 2022

Background and Objectives: Fibrotic lung disease is one of the main complications of many medical conditions. Therefore, the use of anti-fibrotic agents may provide a chance to prevent, or at least modify, such complication. The aim of this study was to evaluate the protective pulmonary anti-fibrotic and anti-inflammatory effects of Dinebra retroflexa. Materials and methods: Dinebra retroflexa methanolic extract and its synthesized silver nanoparticles were tested on bleomycin-induced pulmonary fibrosis. Pulmonary fibrosis was induced by intratracheal instillation of bleomycin (5 mg/5 mL/kg-Saline) as a supposed model for induced lung fibrosis. The weed evaluation was performed by intratracheal instillation of Dinebra retroflexa methanolic extract and its silver nanoparticles (35 mg/100 mL/kg-DMSO, single dose). Results: The results showed that both Dinebra retroflexa methanolic extract and its silver nanoparticles had a significant pulmonary fibrosis retraction potential, with Ashcroft scores of three and one, respectively, and degrees of collagen deposition reduction of 33.8 and 46.1%, respectively. High-resolution UHPLC/Q-TOF-MS/MS metabolic profiling and colorimetrically polyphenolic quantification were performed for further confirmation and explanation of the represented effects. Such activity was believed to be due to the tentative identification of twenty-seven flavonoids and one phenolic acid along with a phenolic content of 57.8 mg/gm (gallic acid equivalent) and flavonoid content of 22.5 mg/gm (quercetin equivalent). Conclusion: Dinebra retroflexa may be considered as a promising anti-fibrotic agent for people at high risk of complicated lung fibrosis. The results proved that further clinical trials would be recommended to confirm the proposed findings.
L’Adresse de G.-T. Raynal à l’Assemblée Nationale. Relecture d’une controverse
Authors: Lüsebrink Hans-Jürgen 
Published: November 2022

Cette contribution analyse la surprenante Adresse à l’Assemblée Nationale
de Guillaume-Thomas Raynal, lue à la tribune et publiée le 31 mai 1791,
sous un triple angle : celui, d’abord, de son contenu et des positions idéologiques qu’elle adopta et qui parurent aux yeux des contemporains radicalement opposées à celles de l’auteur de l’Histoire des Deux Indes (1770/ 1780) qui l’avaient rendu célèbre et l’avaient érigé en véritable «apôtre de la liberté » et fait de lui l’un des «Pères » de la Révolution ; celui, ensuite, des réactions immédiates à cette Adresse au sein de l’Assemblée Nationale, où intervint notamment Maximilien Robespierre ; et enfin, celui des multiples réactions à cette Adresse dans l’espace public français et étranger, visant à expliquer, de diverses manières, le décalage frappant entre les positions politiques de l’Histoire des deux Indes et celles adoptées dans l’Adresse. Cette contribution s’achève sur la synthèse et l’analyse des rumeurs circulant autour du rôle réel de Raynal comme auteur ¢ ou plutôt éditeur ¢ de l’Histoire des deux Indes, rumeurs qui anticipèrent les certitudes auxquelles parvint la recherche contemporaine ayant pu prouver qu’il s’agissait, en définitive, d’un ouvrage collectif dans lequel Diderot occupa un rôle de tout premier plan.
Celebrity endorser dan Promosi terhadap Keputusan Pembelian dengan Brand image sebagai Variabel Intervening
Authors: Saputra Siregar Bona Raja , Yulasmi  , Lusiana  
Published: November 2022

Penelitian ini bertujuan untuk menguji seberapa besar Pengaruh Celebrity endorser Dan Promosi Terhadap Keputusan Pembelian Pada Toko Belanja Online Di Tokopedia Dengan Brand image Sebagai Variabel Intervening Di Kabupaten Merangin. Metode pengumpulan data melalui survei dan mengedarkan kuisioner, dengan sampel 100 responden. Metode analisis yang digunakan adalah metode analisis yang digunakan adalah analisis korelasi, regresi linear berganda dan analisis jalur (path analysis) menggunakan SPSS. Hasil penelitian yang didapatkan berdasarkan uji hipotesis diperoleh terdapat pengaruh yang signifikan antara Celebrity endorser terhadap Brand image. Terdapat pengaruh yang signifikan antara Promosi terhadap Brand image. Terdapat pengaruh yang signifikan antara Celebrity endorser terhadap Keputusan Pembelian. Terdapat pengaruh yang signifikan antara Promosi terhadap Keputusan Pembelian. Terdapat pengaruh yang signifikan antara Brand image terhadap Keputusan Pembelian. Brand image tidak memediasi hubungan antara Celebrity endorser terhadap Keputusan Pembelian. Brand image tidak memediasi hubungan antara Promosi terhadap Keputusan Pembelian.
Decoding Reinforcement Learning for newcomers
Authors: Neves Francisco , F. Reis Matheus , Andrade Gustavo , Aguiar A. Pedro , Pinto Andry Maykol 
Published: November 2022

<p>An intelligible step-by-step Reinforcement Learning (RL) problem formulation and the availability of an easy-to-use demonstrative toolbox for students at various levels (e.g., undergraduate, bachelor, master, doctorate), researchers and educators. This tool facilitates the familiarization with the key concepts of RL, its problem formulation and implementation. The results demonstrated in this paper are produced by a Python program that is released open-source, along with other lecture materials to reduce the learning barriers in such innovative research topic in robotics.</p>
<p>The RL paradigm is showing promising results as a generic purpose framework for solving decision-making problems (e.g., robotics, games, finance). In this work, RL is used for solving a robotics 2D navigational problem where the robot needs to avoid collisions with obstacles while aiming to reach a goal point. A navigational problem is simple and convenient for educational purposes, since the outcome is unambiguous (e.g., the goal is reached or not, a collision happened or not). Thus, the intent is to accelerate the adoption of RL techniques in the field of mobile robotics.</p>
<p>Motivate and promote the adoption of RL techniques to solve decision-making problems, specifically in robotics. </p>
<p>Due to a lack of accessible educational and demonstrative toolboxes concerning the field of RL, this work combines theoretical exposition with an accessible open-source graphical interactive toolbox to facilitate the apprehension.</p>
<p>This study aims to reduce the learning barriers and inspire young students, researchers and educators to use RL as an obvious tool to solve robotics problems.</p>