bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of diffusion tensor imaging and neurophysiological monitoring in the quantitative and predictive evaluation of spinal cord function
Authors: Cao Yue , Liu Xin-Rui , Song Hong-Mei , Chong Shin-Tai , Cui Yu-He , Huang Qi , Yu Ming-Xin , Bai Yang , Xu Hai-Yang , Zhao Gang 
Published: April 2022

Abstract
Objective: To identify which the combination of diffusion tensor imaging (DTI) and neurophysiological monitoring (NM) is reliable in the quantitative and predictive evaluation of spinal cord function. Methods: Data acquisition was collected in 12 patients who underwent ﻿spinal cord tumor surgery in our hospital. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) data of the regions of interest (ROIs) on DTI images were obtained. Preoperative NM and intraoperative neurophysiological monitoring (IONM) were performed. Patients were followed up 2 weeks later. European myelopathy score (EMS score) was recorded pre- and post-operatively. Correlation analysis was conducted to evaluate spinal cord function.Results: The average value of ADC in the two ROIs before operation was higher than that in the area without spinal cord compression (P=0.026), while the average value of FA was the opposite (p=0.018). Preoperative FA value significantly decreased in the fiber-interrupted group and the moderate-to-severe-damage group (P<0.05). The preoperative FA value had more significant positive correlation with the postoperative EMS score (R=0.853, P=0), while the preoperative SEP amplitude had more significant positive correlation with the improvement rate (R=0.826, P=0.001). Conclusion: ﻿For spinal cord tumor patients, the combination of preoperative DTI and NM could quantify the postoperative spinal cord function and predict the prognosis more comprehensively. Preoperative FA value is more valuable to reflect the postoperative subjective symptom, while preoperative SEP amplitude is more meaningful to predict the improvement degree of disease.
The protective effect of aspirin-induced temporary threshold shift in an animal model of cisplatin-related ototoxicity
Authors: Tzelnick Sharon , Mizrachi Aviram , Barkan Neta , Shivatzki Shaked , Yosefof Eyal , Hikri Elad , Attias Joseph , Hilly Ohad 
Published: April 2022

Abstract
purpose: The purpose of this study was to evaluate whether induction of temporary threshold shift (TTS) with aspirin prior to cisplatin exposure can prevent or minimize cisplatin detrimental effects on hearing.Methods: We randomly divided BALB mice into three groups: ]1[ cisplatin only, ]2[ aspirin only, and ]3[ combined aspirin/cisplatin. Cisplatin was administered as a single intraperitoneal injection of 14 mg/kg. Aspirin was administered for three weeks via intraperitoneal injection of 200 mg/kg sodium salicylate, twice daily. Air conduction thresholds were recorded using Auditory Brainstem Responses (ABR). Cochleae were harvested and cochlear hair cells were counted using a scanning electron microscope (SEM).Results: Aspirin-induced TTS have reached an average of 30.05±16.9 dB after two weeks. At 60 days, cisplatin-only treated mice experienced an average threshold shifts of 50.7 dB at 4 kHz, 35.16 dB at 8 kHz, 70dB at 16 kHz, 53.1 dB at 32 kHz. All threshold shifts were significantly worse than for cisplatin/aspirin treated mice with TTS of 11.85 dB at 4 kHz, 3.58 dB at 8 kHz, 16.58 dB at 16 kHz, 20.41dB at 32 kHz (p<0.01). Cochlear cell count with SEM has shown reduction in the number of both inner and outer hair cells in the mid-turn in cisplatin treated mice. Conclusion: Aspirin induced TTS can protect from cisplatin-induced ototoxicity. This beneficial effect was demonstrated by auditory thresholds as well as SEM. Larger pre-clinical and clinical studies are still needed to confirm these findings.
Application of three-dimensional reconstruction of renal tumor vessels to guide laparoscopic partial nephrectomy of hilar tumors and non-hilar tumors under zero ischemia
Authors: Xin SONG , Chen JIANG , Dongming LIU , Wei XUE , Yiran HUANG 
Published: April 2022

Abstract
Objective: To investigate the safety and efficacy of three-dimensional reconstruction of renal tumor vessels to guide laparoscopic partial nephrectomy of hilar tumors and non-hilar tumors under zero ischemia. Methods: The clinical data of 82 patients with renal cancer who underwent zero ischemia retroperitoneal laparoscopic partial nephrectomy in the department of urology of our hospital from January 2018 to January 2021 were retrospectively reviewed. The patients were divided into hilar group and non-hilar group. The clinical data of all patients were statistically analyzed by t-test or χ². Results: There was no significantly difference in gender, age, tumor diameter and pathological stage between hilar and non-hilar tumor group.Most of the target vessels in the hilar tumor group were single targets, while most of the target vessels in the non-hilar tumor group were multiple targets (P<0.05). There was no significantly difference between the groups for mean operative time and length of stay. But hilar tumor group had significantly longer operation time (109.3±9.2 vs. 90.3±9.5 min, p<0.001). There was no significant difference in renal GFR and serum creatinine between the two groups. Hilar tumor group had no significantly difference of change of creatinine and GFR at post-operative 6 and 12 months as compared with non-hilar tumor group. There were no bleeding, urinary leakage, infection and other related complications in the two groups after 1 month follow-up. After 12 months of follow-up, there was no tumor recurrence and metastasis in the two groups. Conclusion: The application of three-dimensional renal tumor vascular reconstruction technology can better realize laparoscopic zero ischemia nephron sparing surgery. The target vessels of patients with hilar, single and early renal cancer are easier to find, which is more suitable for three-dimensional renal tumor vascular reconstruction technology to implement laparoscopic zero ischemia nephron sparing surgery.
Landslide hazard zonation assessment in the Southwestern Highlands of Ethiopia, using integrated approaches of GIS and remote sensing techniques
Authors: Reda Talema Moged , ... Tesfaldet Sisay , Anteneh Zeleke Simachew , .... J Muralitharan Jothimania , Bassa Muluken Fanta 
Published: April 2022

Abstract
Landslide is a common environmental problem in southwestern highlands of Ethiopia. Especially highland area of Konta special woreda is mostly vulnerable for landslide hazards. The study was conducted in northern Konta special woreda which includes Ameya, Gowa, Genji and Chida areas. The main objective of this study was to assess landslide hazard zonation through the integration of GIS and remote sensing techniques. In order to identify sensitivity areas for the occurrence of landslide hazard most important influential factors such as elevation, slope, aspect, drainage density, land-use/land-cover and Normalized difference vegetation index (NDVI) were considered. Further, these factors were weighted using analytical hierarch process method based on their influence for landslide hazard. As a result of this study, very low hazard zonation sites are cover about 10.76 km 2 or 1.78% of the total area whereas low and moderate landslide hazard zonation cover about 259.57 km 2 (38.04%) and 241.86 km 2 (40.02%) respectively. In addition, high and very high landslide hazard zonation are cover about 98.09 km 2 (16.23%) and 24.02 km 2 ( 3.98%) of the total area respectively. Hence, most part of the study area falls under risky landslide hazard zonation. Especially, Ameye and Genji towns is found under higher landslide hazard zonation.
Phosphorus recovery from a pilot-scale grate furnace: influencing factors beyond wet chemical leaching conditions
Authors: Boniardi G. , Turolla A. , Fiameni L. , Gelmi E. , Bontempi E. , Canziani R. 
Published: April 2022

Abstract
Phosphorus is a non-renewable resource going to be exhausted in the future. Sewage sludge ash is a promising secondary raw material due to its high phosphorus content. In this work, the distribution of 19 elements in bottom and cyclone ashes from pilot-scale grate furnace have been monitored to determine the suitability for the phosphorus acid extraction. Moreover, the influence of some parameters beyond wet chemical leaching conditions were investigated. Experimental results showed that bottom ash presented lower contamination in comparison to cyclone ash and low co-dissolution of heavy metals (especially Cr, Pb and Ni), while high phosphorus extraction efficiencies (76–86%) were achieved. High Al content in the bottom ash (9.4%) negatively affected the phosphorus extraction efficiency as well as loss on ignition, while the particle size reduction was necessary for ensuring a suitable contact surface. The typology of precipitating agents did not strongly affect the phosphorus precipitation, while pH was the key parameter. At pH 3.5–5, phosphorus precipitation efficiencies higher than 90% were achieved, with a mean phosphorus content in the recovered material equal to 16–17%, comparable to commercial fertilizers. Instead, the co-precipitation of Fe and Al had a detrimental effect on the recovered material, indicating the need for additional treatments.
LncRNA SBF2-AS1: A Budding Star in Various Cancers
Authors: Tan Fangshun , Chen Jinlan , Wang Bei , Du Zhuoying , Mou Jie , Wu Yinxin , Liu Yuling , Zhao Fangnan , Yuan Chengfu 
Published: April 2022

Abstract:
Long non-coding RNA (lncRNA) is a new kind of RNA with a length of over 200 nucleotides. Current
frontiers revealed that lncRNAs implicate in various tumor progression, including tumorigenesis, proliferation,
migration, invasion, metastasis, and angiogenesis. Recently discovered long non-coding RNA SETbinding
factor 2 antisense RNA 1 (lncRNA SBF2-AS1), an oncogenic antisense RNA to SBF2, locates at
11p15.1 locus and is 2708 nt long. Accumulating evidence has demonstrated that lncRNA SBF2-AS1 participates
in the progression of the various tumor, including pathogenesis, diagnosis, treatment, and prognosis of
acute myeloid leukemia (AML), breast cancer (BC), cervical cancer (CC), clear cell renal cell carcinoma
(ccRCC), colorectal cancer (CRC), diffuse large B-cell lymphoma (DLBCL), esophageal squamous cell carcinoma
(ESCC), gastric cancer (GC), glioma, glioblastoma (GBM), hepatocellular carcinoma (HCC), lung cancer
(LC), lung adenocarcinoma (LUAD), non-small cell lung cancer (NSCLC), osteosarcoma (OS), pancreatic cancer
(PC), papillary thyroid cancer (PTC), small cell lung cancer (SCLC). Therefore, we summarized the underlying
mechanisms of lncRNA SBF2-AS1 in various cancers to utilize its therapeutic function in target-selective
treatment modalities.
New Trends in Nontransplant Therapy for Acquired Aplastic Anemia
Authors: Ding Shaoxue , Fu Rong 
Published: April 2022

Abstract:
Aplastic anemia (AA) is a hematological disease characterized by pancytopenia and hypofunctional
bone marrow hematopoiesis. Patients with AA are treated with either immunosuppressive therapy (IST) using
anti-thymocyte globulin (ATG) and cyclosporine (CsA) or hematopoietic stem cell transplantation (HSCT), if a
matched donor is available. The standard IST regimen for AA patients results in response rates up to 70% and
even higher overall survival. However, primary and secondary failures after IST remain frequent, and to date,
all attempts aiming to overcome this problem have been unfruitful. The nontransplant therapeutic options for
AA have significantly expanded during the last few years. Here, we review the new trends of nontransplant
therapy for AA and summarize the current therapeutic effect of AA.
Liposomes in the Targeted Gene Therapy of Cancer: A Critical Review
Authors: Akkewar Ashish , Mahajan Nilesh , Kharwade Rohini , Gangane Purushottam 
Published: April 2022

Abstract:
Cancer immunotherapy has advanced significantly in recent years. Nanocarriers like liposomes
can improve cancer immunotherapy and even stronger immune responses by improving cell
type-specific distribution. Liposomes are lipid bilayer vesicles that are biodegradable and biocompatible
and are often used as smart delivery systems for both hydrophobic and hydrophilic bioactive. Whereas
the idea of employing liposomes for administering drugs has been known since the 1960s, the early
2000s saw continuing technological advances and formulations for drug entrapment and manufacturing.
Modern deterministic studies have tried discovering more about how genetic material is delivered
through liposomes. Liposomes' interactions with cells are still a bit of mystery. Liposome-mediated
transmission of genetic material experiences systemic impediments perlysosomal degradation, endosomal
escape, and nuclear uptake. Controlling the physical architecture and chemical properties of liposome
structures, such as lipid-to-DNA charge, ester bond composition, size, and ligand complexation
structure, is critical for targeting liposomes' success as vehicles for gene delivery. This analysis focuses
on advancements in ligand-targeted liposomes and theranostic (diagnostic) liposomes for cancer diagnosis
and treatment. This review will explore the numerous transgene mechanisms and molecular targets
implicated in cancer cell death and the associated benefits of using liposomal formulations
throughout the years. This sequence of breakthroughs will interest aspiring researchers and the pharmaceutical
industry involved in liposome development.
Alzheimer’s Disease-Related Psychosis: An Overview of Clinical Manifestations,
Pathogenesis, and Current Treatment
Authors: Benmelouka Amira Y. , Ouerdane Yassamine , Outani Oumaima , Alnasser Yusra T. , Alghamdi Badrah S. , Perveen Asma , Ashraf Ghulam Md. , Ebada Mahmoud Ahmed 
Published: April 2022

Abstract:
Behavioral and psychotic manifestations, including aggression, delusions, and hallucinations,
are frequent comorbidities in patients with debilitating nervous illnesses such as Alzheimer’s
disease (AD), Amyotrophic Lateral Sclerosis, Multiple Sclerosis, and Parkinson’s disease. ADrelated
psychosis may be linked to a poor disease prognosis, highlighting that early detection and
management are mandatory. The manifestations are variable and may be very heterogeneous, imposing
a real diagnostic issue. Some assessment tools such as BEHAVE-AD, CERAD-BRSD, and the
Psycho-Sensory Hallucinations Scale have been designed to facilitate the diagnosis. The mechanisms
behind neurodegeneration-related psychosis are complex and are not fully understood, imposing a
burden on researchers to find appropriate management modalities. Familial history and some genetic
disturbances may have a determinant role in these delusions and hallucinations in cases with AD.
The loss of neuronal cells, atrophy in some regions of the central nervous, and synaptic dysfunction
may also contribute to these comorbidities. Furthermore, inflammatory disturbances triggered by
pro-inflammatory agents such as interleukins and tumor necrosis factors are stratified among the potential
risk factors for the onset of numerous psychotic symptoms in Alzheimer’s patients. Little is
known about the possible management tools; therefore, it is urgent to conduct well-designed trials to
investigate pharmacological and non-pharmacological interventions that can improve the care process
of these patients. This review summarizes the current findings regarding the AD-related psychosis
symptoms, pathological features, assessment, and management.
The Human Right to Adequate Food in Brazil: A Multidisciplinary
Approach
Authors: Evangelista Alberto Gonçalves , Prestes Raphael Jayson 
Published: April 2022

Abstract:
Over the years, especially after the French Revolution and World War II, human
rights have been internalized by several institutions and legislation worldwide, such as the United
Nations (UN). However, in practice, much still needs to be done for the regulations to be applied.
In Brazil, although the right to food is guaranteed in the Federal Constitution, there is still
a wide disparity in per capita food acquisition in the different regions, with greater acquisitions
in the South, Southeast, and Midwest regions and a significant decrease in the North and Northeast
regions. In addition, the use of antibiotics as performance enhancers (or growth promoters)
in animal production can put the population's health at risk, given the antimicrobial resistance to
important drugs used in human medicine. Thus, the objective of this work is to interdisciplinary
defend the good nutrition of Brazilians.
Recent Updates and Technological Developments in Evaluating Cardiac
Syncope in the Emergency Department
Authors: Ojha Utkarsh , Ayathamattam James , Okonkwo Kenneth , Ogunmwonyi Innocent 
Published: April 2022

Abstract:
Syncope is a commonly encountered problem in the emergency department (ED), accounting
for approximately 3% of presenting complaints. Clinical assessment of syncope can be
challenging due to the diverse range of conditions that can precipitate the symptom. Annual mortality
for patients presenting with syncope ranges from 0-12%, and if the syncope is secondary to a
cardiac cause, then this figure rises to 18-33%. In ED, it is paramount to accurately identify those
presenting with syncope, especially patients with an underlying cardiac aetiology, initiate appropriate
management, and refer them for further investigations. In 2018, the European Society of
Cardiology (ESC) updated its guidelines with regard to diagnosing and managing patients with
syncope. We highlight recent developments and considerations in various components of the workup,
such as history, physical examination, investigations, risk stratification, and novel biomarkers,
since the establishment of the 2018 ESC guidelines. We further discuss the emerging role of artificial
intelligence in diagnosing cardiac syncope and postulate how wearable technology may transform
evaluating cardiac syncope in ED.
Efficacy of Mesenchymal Stem Cells from Human Exfoliated Deciduous
Teeth and their Derivatives in Inflammatory Diseases Therapy
Authors: Su Junxiang , Ge Xuejun , Jiang Nan , Zhang Ziqian , Wu Xiaowen 
Published: April 2022

Abstract:
Mesenchymal stem cells derived from postnatal orofacial tissues can be readily isolated and
possess diverse origins, for example, from surgically removed teeth or gingiva. These cells exhibit stem
cell properties, strong potential for self-renewal, and show multi-lineage differentiation, and they have
therefore been widely employed in stem cell therapy, tissue regeneration, and inflammatory diseases.
Among them, stem cells from human exfoliated deciduous teeth [SHED] and their derivatives have
manifested wide application in the treatment of diseases because of their outstanding advantages—
including convenient access, easy storage, and less immune rejection. Numerous studies have shown that
most diseases are closely associated with inflammation and that inflammatory diseases are extremely
destructive, can lead to necrosis of organ parenchymal cells, and can deposit excessive extracellular matrix
in the tissues. Inflammatory diseases are thus the principal causes of disability and death from many
diseases worldwide. SHED and their derivatives not only exhibit the basic characteristics of stem cells but
also exhibit some special properties of their own, particularly with regard to their great potential in inhibiting
inflammation and tissue regeneration. SHED therapy may provide a new direction for the treatment
of inflammation and corresponding tissue defects. In this review, we critically analyze and summarize the
latest findings on the behaviors and functions of SHED, serum‑free conditioned medium from SHED
[SHED-CM], and extracellular vesicles, especially exosomes, from SHED [SHED-Exos], and discuss
their roles and underlying mechanisms in the control of inflammatory diseases, thus further highlighting
additional functions for SHED and their derivatives in future therapies.
Cryptolepine Targets TOP2A and Inhibits Tumor Cell Proliferation in Breast Cancer Cells -An In vitroandIn silicoStudy
Authors: Mehraj Umar , Qayoom Hina , Shafi Shazia , Farhana Pzd , Asdaq Syed Mohammed Basheeruddin , Mir Manzoor Ahmad 
Published: April 2022

Background:DNA Topoisomerase II Alpha (TOP2A), a protein-coding gene, is central to the replication process and has been found deregulated in several malignancies, including breast cancer. Several therapeutic regimens have been developed and approved for targeting TOP2A and have prolonged the survival of cancer patients. However, due to the inherent nature of the tumor cell to evolve, the earlier positive response turns into a refractory chemoresistance in breast cancer patients.Objective:The study’s main objective was to analyze the expression pattern and prognostic significance of TOP2A in breast cancer patients and screen new therapeutic molecules targeting TOP2A.Methods:We utilized an integrated bioinformatic approach to analyze the expression pattern, genetic alteration, immune association, and prognostic significance of TOP2A in breast cancer (BC) and screened natural compounds targeting TOP2A, and performed an in-silico and an in vitro analysis.Results:Our study showed that TOP2A is highly overexpressed in breast cancer tissues and overexpression of TOP2A correlates with worse overall survival (OS) and relapse-free survival (RFS). Moreover, TOP2A showed a high association with tumor stroma, particularly with myeloid-derived suppressor cells. Also, in silico and in vitro analysis revealed cryptolepine as a promising natural compound targeting TOP2A.Conclusion:Cumulatively, this study signifies that TOP2A promotes breast cancer progression, and targeting TOP2A in combination with other therapeutic agents will significantly enhance the response of BC patients to therapy and reduce the development of chemoresistance.
Study of Multi-layered Cobalt Silicide Nanostructured Thin Films Prepared
by Ion Beam Sputtering
Authors: Kumar Anil , Kaur Karamjit 
Published: April 2022

Aims:
This work focuses on the different existing techniques for synthesis of nanomaterials,
the selection of potential process for preparation of Co/Si and Co/Si/Co such that material with optimum
characteristics may be obtained.

Background:
The process of synthesis plays a crucial role in physical properties and associated phenomena
acquired by them, and hence is a deciding factor in various potential applications of the materials.

Objective:
The aim of the study was to investigate the properties of multi-layered cobalt silicide
nanostructured thin films prepared by ion beam sputtering.

Method:
The cobalt silicide is selected for synthesis using IBS technique owing to vast scope of its
application in manufacturing microelectronic devices.

Result:
The formation of nanostructured layers has been confirmed through XRD and XRR patterns.

Conclusion:
The role of substrate thickness, interface quality and crystalline structure is very important
in deciding properties of multilayer nano-structured thin films.