bluuebunny/crossref_metadata_2025_split huggingface dataset:
POTENSI BIOAKARISIDA EKSTRAK DAUN MIMBA (Azadirachta Indica) DAN BUNGA CENGKEH (Syzygium Aromaticum) TERHADAP TUNGAU PENYEBAB PENYAKIT KREPES PADA JAMUR KUPING
Authors: Apra Meilani , Aniek Prasetyaningsih  , Kukuh Madyaningrana  
Published: June 2022

Wood ear mushrooms is commonly known as one of the cultivated edible mushrooms in Indonesia. The demand for this commodity is still steadily high and leads mushroom farmers to optimize its cultivation. For mushroom farmers in Yogyakarta, the prevalence of krepes disease which is caused by a group of species belongs to Acarina order is still high and leads to total loss of harvest. In order to diminish these Acarina species, the use of chemical acaricides is common because of their effectiveness in eradicating the pests despite their toxic effect to the environment. A strategy to provide environmental friendly acaricides which are extracted from plants is therefore important. This research aimed to study the potency of neem leaves (Azadirachta indica) and clove flowers (Eugenia caryophyllata) extracts as bioacarisides for Acarina species as the causal agent of krepes disease. Neem leaves and cloves flowers were extracted using maceration and soxhlet extraction methods, using 96% methanol as their solvents. Obtained crude extracts would then be subjected to phytochemical analysis using qualitative biochemical tests and GC-MS. The effectivity of extracts as bioacaricides were tested both in in vitro and field scale. In vitro tests showed that neem leaves extract and clove flower extract had LC50 value ​​of 0.22% and 0.48% respectively. Field scale test on mushroom baglogs showed that the efficacy of the neem leaves and clove flower to eradicate acarina were above 50%. Taken together, neem leaves and clove flower extracts are potential to be used as bioacaricides in mushroom farming.
The Influence of Health Education on Mom's Knowledge and Attitude About Infant Massage
Authors: Andria Andria , Wulandari Sri , Handayani Eka Yulia , Ayuningtiyas Ratih , Ovari Isna 
Published: June 2022

Baby massage is an activity to simulate or sequence the baby's head with touch, movement, plus auditory stimulation and visual stimulation. The benefits of baby massage can make babies relax, establish affection between parents and children, and also train children's motor skills. Babies who routinely undergo baby massage are proven to have more motor intelligence than babies who rarely get it. The purpose of this study was to determine the effect of health education on mothers' knowledge and attitudes about infant massage in Pasir Makmur Village, Rambah Samo District, Rokan Hulu Regency. This type of research is a quasi experiment with a one group pretest posttest without control design. The number of samples is 65 people who are determined by total sampling technique. The statistical test used is the paired t test. The results showed that the average knowledge of respondents before being given health education about baby massage was 68.76 and after being given health education it was 88.18. The attitude of the respondents before being given health education on average was 42.04 and after being given health education it became 45.48. Based on the results of statistical tests there is an effect of health education on mother's knowledge and attitudes about infant massage with statistical test results obtained p values ​​are 0.0003 and 0.0002 (p <0.05). It is hoped that further research will not only provide health education but baby massage training so that mothers do not only massage their babies but can also be an effort for mothers to obtain a lot of material.
Keywords: Health Education, Baby Massage, Infant Message
Design and Simulation of CNC Milling Machine on Matlab
Authors: Gumono Gumono , Mira Mira , Hadi Samsul , Perkasa Rilis Eka 
Published: June 2022

The development and revision of milling machines and components are continuous. With the help of computer technology, we can simulate some activities in a manufacturing system. The main purpose of a simulation is to understand and imitate the behavior of a particular manufacturing system on a computer, before hardware creation, thereby reducing the amount of testing and experimentation in the field. By using a virtual system, less material is wasted and the constraints on the actual operation of the machine in the field can be minimized. In the field of milling machinery, various modeling and simulation methods have been introduced so far. Today, the manufacture of a machine tool can no longer use the time-consuming and costly manufacturing and testing of physical prototypes to detect weak points and then optimize the design. In contrast, the current machine tool design process uses "virtual prototyping" technology to reduce the cost and time of hardware testing and iterative improvements to physical prototypes. The model of a milling machine can be simulated in Matlab simulations through analytical methods using various compositions. The presented virtual modeling methods and milling machine tool simulations make it possible to design, perform complex analyses, test, optimize, and use various types of control structures. in the computer simulation.
Keywords: Milling Machine, CNC Miling Machine, Matlab
An Analysis of Effect GSM Signal Type on Android-Based Vehicle Injector Response Time
Authors: Martawati Mira Esculenta , Rohman Fatkhur , Susilo Sugeng Hadi , Cahyo Bagus Dwi 
Published: June 2022

The crime of motor vehicle theft is increasing, the automotive industry continues to develop security systems to reduce the number of thefts that occur in Indonesia through the development of sophisticated features. The addition of a global positioning system (GPS) feature on a vehicle is an alternative to supporting a security system by providing vehicle location information when theft occurs. GPS provides location information by providing microcontroller input data. GPS on the vehicle becomes very important because with the GPS module the vehicle can be found by knowing an accurate location. However, the addition of a GPS module is often difficult to find because the distance changes frequently and it takes a long time to find it. The purpose of this paper is to detect vehicle position accurately using GPS U-Blox NEO 6M and to analyze the effect of GSM signal type on the response time of long-distance vehicle injectors based on android. The research method is data analysis to make conclusions, namely the two-way factor quantitative experimental method. The independent variables used are (1) different signal types, and (2) the distance from the signal source to the gasoline engine injector response time. The conclusion obtained is that vehicle position detection using GPS U-Blox NEO 6M is accurate with the results of data analysis shifting 8.3113 meters and the interaction between distance and GSM signal types has no significant effect with the results of data analysis from the three types of Telkomsel GSM signals which are the fastest with a distance of 200 meters from the signal source with a response time of 4.956 seconds and the slowest is XL at a distance of 500 meters from the signal source with a response time of 8.5 seconds.
Keywords: Android-Based Vehicle Injector, GSM Signal Type, Vehicle Injector
Att synliggöra ett fritidspedagogiskt förhållningssätt
Authors: Lago Lina , Elvstrand Helene , Hertz Katharina , Hjelm Johan , Johansson Klas , Petersson Micaela , Andersson Christoffer , Arnryd Oscar , Eichouh Jamila , Nilsson Kajsa , Wållberg Anton 
Published: June 2022

Vad är kärnan i fritidshemmets undervisning, hur kan fritidspedagogiska förhållningssätt synliggöras och utvecklas och vad kräver det för lärarposition? Sådana frågor har varit utgångspunkt för det ULF-projekt som presenteras i denna artikel.
Systemic Blood Predictors of Elevated Pulmonary Artery Pressure Assessed by Non-invasive Echocardiography After Acute Exposure to High Altitude: A Prospective Cohort Study
Authors: Bian Shi-Zhu , Zhang Chen , Rao Rong-Sheng , Ding Xiao-Han , Huang Lan 
Published: June 2022

AimElevated pulmonary artery pressure (ePAP) in response to high-altitude hypoxia is a critical physiopathological factor in the hypoxic adaptation that may lead to high-altitude pulmonary edema in the acute phase or high-altitude pulmonary hypertension in the long term. However, the sea-level predictors of risk factors for altitude-induced ePAP have not been examined. Thus, we aimed to identify the baseline systemic blood predictors of ePAP after acute high-altitude exposure.Materials and MethodsA total of 154 participants were transported to a high altitude 3,700 m from sea level within 2 h. Echocardiography examinations were performed to assess the mean pulmonary artery pressure (mPAP) and hemodynamics at both altitudes. All the individuals underwent blood tests to determine the concentrations of vascular regulatory factors. Univariate and adjusted logistic regression analyses were performed to identify the independent predictors of ePAP and factors related to ePAP.ResultsThe mPAP increased significantly from sea level to high altitude (19.79 ± 6.53–27.16 ± 7.16 mmHg, p &lt; 0.05). Increased levels of endothelin (ET-1), Ang (1–7), Ang II, and bradykinin were found after high-altitude exposure, while the levels of nitric oxide (NO), prostaglandin E2 (PEG2), and serotonin decreased sharply (all p-values &lt; 0.05). At high altitude, 52.6% of the subjects exhibited ePAP, and the mPAP was closely correlated with the baseline Ang II level (r = 0.170, p = 0.036) and follow-up levels of NO (r = −0.209, p = 0.009), Ang II (r = 0.246, p = 0.002), and Ang (1–7) (r = −0.222, p = 0.006) and the left atrial inner diameter (LAD, r = 0.270, p &lt; 0.001). Both the baseline and follow-up NO and Ang II levels were significantly different between the ePAP and non-ePAP groups. Finally, we identified the baseline Ang II and NO concentrations as two independent predictors of ePAP (p &lt; 0.05). We also found that two vascular regulatory factors with inverse roles, namely, Ang (1–7) and Ang II, at high altitudes were independently associated with ePAP. Additionally, ET-1, NO, PEG2, and LAD were associated with ePAP.ConclusionThe baseline concentrations of Ang II and NO at sea level are two independent predictors of ePAP after acute high-altitude exposure. Furthermore, Ang (1-7) and Ang II combined with ET-1, NO, PEG2, and LAD at high altitudes may contribute to the development of ePAP.
Fibrinolytic Proteins and Factor XIII as Predictors of Thrombotic and Hemorrhagic Complications in Hospitalized COVID-19 Patients
Authors: Marchetti Marina , Gomez-Rosas Patricia , Russo Laura , Gamba Sara , Sanga Eleonora , Verzeroli Cristina , Ambaglio Chiara , Schieppati Francesca , Restuccia Francesco , Bonanomi Ezio , Rizzi Marco , Fagiuoli Stefano , D’Alessio Andrea , Gerotziafas Grigorios T. , Lorini Luca , Falanga Anna 
Published: June 2022

IntroductionIn a prospective cohort of hospitalized COVID-19 patients, an extensive characterization of hemostatic alterations by both global and specific assays was performed to clarify mechanisms underlying the coagulopathy and identify predictive factors for thrombotic and hemorrhagic events during hospitalization.Materials and MethodsIntensive care unit (ICU; n = 46) and non-ICU (n = 55) patients were enrolled, and the occurrence of thrombotic and hemorrhagic events was prospectively monitored. At study inclusion, thromboelastometry together with the measurement of specific coagulation proteins and hypercoagulation markers was performed.ResultsPatients (median age 67 years) showed significantly shorter clot formation time together with greater maximum clot firmness by thromboelastometry, increased levels of F1 + 2 and D-dimer, as biomarkers of hypercoagulability, and of procoagulant factors V, VIII, IX, XI, and fibrinogen, while FXIII was significantly reduced. The concentration of fibrinolytic proteins, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) were elevated in the overall cohort of patients. Many of these hemostatic alterations were significantly greater in ICU compared to non-ICU subjects and, furthermore, they were associated with inflammatory biomarker elevation [i.e., interleukin 6 (IL-6), C-reactive protein (CRP), neutrophil to lymphocyte ratio (NLR), and procalcitonin]. After enrollment, 7 thrombosis and 14 major bleedings occurred. Analysis of clinical and biological data identified increased t-PA, PAI-1, and NLR values as independent predictive factors for thrombosis, while lower FXIII levels were associated with bleeding.ConclusionThis study demonstrates alterations in all different hemostatic compartments analyzed, particularly in severe COVID-19 conditions, that strongly correlated with the inflammatory status. A potential role of fibrinolytic proteins together with NLR and of FXIII as predictors of thrombotic and hemorrhagic complications, respectively, is highlighted.
Demographic, Clinical and Laboratory Characteristics of Ocular Syphilis: 6-Years Case Series Study From an Eye Center in East-China
Authors: Sun Chuan-bin , Liu Geng-hao , Wu Rong , Liu Zhe 
Published: June 2022

PurposeTo report the demographic, clinical, and laboratory characteristics of ocular syphilis based on a 6-year case series study from an eye center in East-China.MethodsA total of 131 cases (191 eyes) of ocular syphilis and the annual number of total syphilis cases from January 2016 to December 2021, were included in this study. Detailed medical records including systemic and ophthalmic medical history, a complete ophthalmic examination, color fundus photography, B-type ultrasound, fundus fluorescein angiography (FFA), spectral domain optical coherence tomography (SD-OCT), laboratory tests of the serum and cerebrospinal fluid (CSF) samples, as well as visual field test and orbital or cranial MRI in cases with suspected optic neuritis or optic atrophy, were collected and analyzed. Pearson Chi-square or Fisher’s exact tests was used for statistics analysis.ResultsOf the 131 cases with ocular syphilis, 86 cases were in men and 6 cases had a past medical history or systemic manifestation of syphilis. HIV was found in only 2 of 70 cases undergoing serum HIV test. The average age was 54.0 years, ranging from 26–85 years. The average percentage of ocular syphilis out from the total syphilis cases was 5.1%, the average titer of serum rapid plasma regain (RPR) at presentation was 1:32, ranging from 1:1–1:512. The most predominant manifestation of ocular syphilis was posterior uveitis, followed by optic neuritis, optic atrophy, panuveitis, retinal vasculitis, and retinitis. The median of BCVA of all 191 eyes was 20/200 (ranging from no light perception to 20/20), and 20/40 (ranging from no light perception to 20/20) at presentation and final follow-up, respectively. Ocular syphilis with active inflammation responded well to penicillin therapy, no matter the initial visual acuity, ocular disease type, or RPR titers, as long as it was diagnosed early and treated properly and promptly. However, cases with optic atrophy, acute retinal necrosis, late diagnosis, permanent disruption, or loss of outer segment of photoreceptors of macular retina on SD-OCT showed poor visual improvement after therapy.ConclusionsEarly diagnosis of ocular syphilis is still challenging in clinical practice and syphilis tests should be routinely performed in patients with uveitis, retinitis, optic neuritis, and optic atrophy.
Association of Total Calcium With Serum Uric Acid Levels Among United States Adolescents Aged 12–19 Years: A Cross-Sectional Study
Authors: Gu Fang , Luo Xiaoming , Jin Xiaoli , Cai Changshou , Zhao Wenyan 
Published: June 2022

AimsEvidence of a link between total calcium (CA) and serum uric acid (SUA) is absent in adolescents. Thus, this study aimed to determine the relationship between total CA levels and SUA levels in United States adolescents.MethodsA cross-sectional study analyzed a sample composed of 8,309 United States adolescents aged 12–19 years from the National Health and Nutrition Examination Survey database (1999–2006 survey cycle). Multivariable linear regression analyses and multivariable logistic regression analyses were used to assess the correlation of total CA with SUA levels and hyperuricemia. Furthermore, the dose-response relationship of total CA and SUA levels was analyzed using smooth curve fitting (penalized spline method).ResultsAccording to multivariable linear regression analysis, every 1 mg/dL increase in total CA level is associated with a 0.33 mg/dL (β = 0.33, 95% CI: 0.27–0.40, p &lt; 0.001) increase in SUA. Multivariable logistic regression analyses showed that every 0.1 mg/dL increase in total CA level is linked with an 8% increased risk of hyperuricemia (OR = 1.08, 95% CI: 1.06–1.10, p &lt; 0.001). The analyses of smooth curve fitting revealed that total CA levels were linearly correlated with SUA levels (Pnon–linearity = 0.152). The results were highly stable in all subgroups. The interaction analysis results presented that race/ethnicity had an interactive role in associating total CA with SUA levels.ConclusionsIn United States adolescents, total CA levels were linearly and positively correlated with SUA levels.
Elevated Lipoprotein-Associated Phospholipase A2 Is Associated With Intracranial Atherosclerosis
Authors: Wang Yuan , Liu Gang , Song Haiqing , Cao Catherine , Ji Xunming , Cao Guodong 
Published: June 2022

BackgroundLipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory factor in the pathogenesis of atherosclerotic plaque and is associated with an increased risk of ischemic stroke. Whether Lp-PLA2 is associated with stenosis subtypes in acute ischemic stroke (AIS) has not been investigated.MethodsA total of 126 eligible AIS patients were divided into four groups: (1) no cerebral artery stenosis (NCS); (2) intracranial artery stenosis (ICAS); (3) extracranial artery stenosis (ECAS); and (4) combined intracranial and extracranial artery stenosis (IECS). Associations between serum Lp-PLA2 levels and the stenosis subtypes were assessed.ResultsThe ICAS group had a lower frequency of dyslipidemia as compared to the NCS group and the IECS group (35.3% vs. 70% vs. 71.8%, respectively, p = 0.001) and was more likely to be symptomatic than the ECAS group (76.5% vs. 43.8%, respectively, p = 0.014). Lp-PLA2 levels in the ICAS group were 112.2 ± 66.8 μg/L which are, higher than those in the NCS, ECAS, and IECS groups (81.7 ± 38.5, 106.1 ± 57.8, 89.3 ± 52.2 μg/L, respectively, p = 0.025). In the third and fourth quartiles of Lp-PLA2 levels, stenosis had occurred more frequently in the ICAS group than in the other three groups (third Q: 50.0% vs. 3.1% vs. 28.1% vs. 18.8%, p = 0.002; fourth Q: 48.4% vs. 16.1% vs. 25.8% vs. 9.7%, p = 0.014). Lp-PLA2 levels were higher in patients with more or severe stenosis in the ICAS group.ConclusionsElevated Lp-PLA2 levels were differentially associated with increased risk in AIS patients with ICAS compared to those with ECAS or no stenosis. Lp-PLA2 may be a promising biomarker and potential therapeutic target for ICAS.
Diagnostic Value of Multimodal Intraoperative Neuromonitoring by Combining Somatosensory-With Motor-Evoked Potential in Posterior Decompression Surgery for Thoracic Spinal Stenosis
Authors: Liu Tun , Yan Liang , Qi Huaguang , Luo Zhenguo , Liu Xuemei , Yuan Tao , Dong Buhuai , Zhao Yuanting , Zhao Songchuan , Li Houkun , Liu Zhian , Wu Xucai , Wang Fei , Wang Wentao , Huang Yunfei , Wang Gang 
Published: June 2022

BackgroundIntraoperative neuromonitoring (IONM) has become an increasingly essential technique in spinal surgery. However, data on the diagnostic value of IONM in predicting impending postoperative neurological deficits (PONDs) for patients who underwent posterior decompression surgery for thoracic spinal stenosis (TSS) are limited. Furthermore, patients who are at the highest risk of waveform changes during the surgery remain unknown. Our purpose was to (1) assess the diagnostic accuracy of IONM by combining somatosensory-evoked potential (SSEP) with motor-evoked potential (MEP) in predicting PONDs for patients who underwent the surgery and (2) identify the independent risk factors correlated with IONM changes in our study population.MethodsA total of 326 consecutive patients who underwent the surgery were identified and analyzed. We collected the following data: (1) demographic and clinical data; (2) IONM data; and (3) outcome data such as details of PONDs, and recovery status (complete, partial, or no recovery) at the 12-month follow-up visit.ResultsIn total, 27 patients developed PONDs. However, 15, 6, and 6 patients achieved complete recovery, partial recovery, and no recovery, respectively, at the 12-month follow-up. SSEP or MEP change monitoring yielded better diagnostic efficacy in predicting PONDs as indicated by the increased sensitivity (96.30%) and area under the receiver operating characteristic (ROC) curve (AUC) value (0.91). Only one neurological deficit occurred without waveform changes. On multiple logistic regression analysis, the independent risk factors associated with waveform changes were as follows: preoperative moderate or severe neurological deficits (p = 0.002), operating in the upper- or middle-thoracic spinal level (p = 0.003), estimated blood loss (EBL) ≥ 400 ml (p &lt; 0.001), duration of symptoms ≥ 3 months (p &lt; 0.001), and impairment of gait (p = 0.001).ConclusionSomatosensory-evoked potential or MEP change is a highly sensitive and moderately specific indicator for predicting PONDs in posterior decompression surgery for TSS. The independent risks for IONM change were as follows: operated in upper- or middle-thoracic spinal level, presented with gait impairment, had massive blood loss, moderate or severe neurological deficits preoperatively, and had a longer duration of symptoms.Clinical Trial Registration[http://www.chictr.org.cn]; identifier [ChiCTR 200003 2155].
Predictors of Lung Adenocarcinoma With Leptomeningeal Metastases: A 2022 Targeted-Therapy-Assisted molGPA Model
Authors: Zhang Milan , Tong Jiayi , Ma Weifeng , Luo Chongliang , Liu Huiqin , Jiang Yushu , Qin Lingzhi , Wang Xiaojuan , Yuan Lipin , Zhang Jiewen , Peng Fuhua , Chen Yong , Li Wei , Jiang Ying 
Published: June 2022

ObjectiveTo explore prognostic indicators of lung adenocarcinoma with leptomeningeal metastases (LM) and provide an updated graded prognostic assessment model integrated with molecular alterations (molGPA).MethodsA cohort of 162 patients was enrolled from 202 patients with lung adenocarcinoma and LM. By randomly splitting data into the training (80%) and validation (20%) sets, the Cox regression and random survival forest methods were used on the training set to identify statistically significant variables and construct a prognostic model. The C-index of the model was calculated and compared with that of previous molGPA models.ResultsThe Cox regression and random forest models both identified four variables, which included KPS, LANO neurological assessment, TKI therapy line, and controlled primary tumor, as statistically significant predictors. A novel targeted-therapy-assisted molGPA model (2022) using the above four prognostic factors was developed to predict LM of lung adenocarcinoma. The C-indices of this prognostic model in the training and validation sets were higher than those of the lung-molGPA (2017) and molGPA (2019) models.ConclusionsThe 2022 molGPA model, a substantial update of previous molGPA models with better prediction performance, may be useful in clinical decision making and stratification of future clinical trials.