bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous renal replacement therapy is a safe and effective modality for the initial management of dogs with acute kidney injury
Authors: Chen Hilla , Klainbart Sigal , Kelmer Efrat , Segev Gilad 
Published: October 2022

Abstract

OBJECTIVE
To describe the management of dogs with acute kidney injury (AKI) by continuous renal replacement therapy (CRRT), and to investigate the relationship between a prescribed CRRT dose, the hourly urea reduction ratio (URR), and the overall efficacy.

ANIMALS
45 client-owned dogs diagnosed with severe AKI, receiving 48 CRRT treatments at a veterinary teaching hospital.

PROCEDURES
Retrospective study. Search of medical records of dogs with AKI managed by CRRT.

RESULTS
Median serum urea and creatinine at CRRT initiation were 252 mg/dL [Inter quartile range (IQR), 148 mg/dL; range, 64 to 603 mg/dL] and 9.0 mg/dL (IQR, 7 mg/dL; range, 4.3 to 42.2 mg/dL), respectively. Median treatment duration was 21 hours (IQR, 8.8 hours; range, 3 to 32 hours). Systemic heparinization and regional citrate anticoagulation were used in 24 treatments each (50%). The prescribed median CRRT dose for the entire treatment was 1 mL/kg/min (IQR, 0.4 mL/kg/min; range, 0.3 to 2.5 mL/kg/min). The median hourly URR was 4% (IQR, 1%; range, 2% to 12%), overall URR was 76% (IQR, 30%; range, 11% to 92%) and median Kt/V was 2.34 (IQR, 1.9; range, 0.24 to 7.02). The CRRT dose was increased gradually from 0.9 mL/kg/min to 1.4 mL/kg/min (P < .001) and the hourly URR decreased from 6.5% to 5.5% (P = .05). The main complication was clotting of the extra-corporeal circuit, occurring in 6/48 treatments (13%). Twenty-four dogs (53%) survived to discharge.

CLINICAL RELEVANCE
CRRT is safe when the prescription is based on the current veterinary guidelines for gradual urea reduction. Treatment efficacy can be maximized by gradually increasing the dose according to the actual URR.
Energy endocrine physiology, pathophysiology, and nutrition of the foal
Authors: Kinsella Hannah M. , Hostnik Laura D. , Toribio Ramiro E. 
Published: October 2022

Abstract
Most homeostatic systems in the equine neonate should be functional during the transition from intra- to extrauterine life to ensure survival during this critical period. Endocrine maturation in the equine fetus occurs at different stages, with a majority taking place a few days prior to parturition and continuing after birth. Cortisol and thyroid hormones are good examples of endocrine and tissue interdependency. Cortisol promotes skeletal, respiratory, cardiovascular, thyroid gland, adrenomedullary, and pancreatic differentiation. Thyroid hormones are essential for cardiovascular, respiratory, neurologic, skeletal, adrenal, and pancreatic function. Hormonal imbalances at crucial stages of development or in response to disease can be detrimental to the newborn foal. Other endocrine factors, including growth hormone, glucagon, catecholamines, ghrelin, adipokines (adiponectin, leptin), and incretins, are equally important in energy homeostasis. This review provides information specific to nutrition and endocrine systems involved in energy homeostasis in foals, enhancing our understanding of equine neonatal physiology and pathophysiology and our ability to interpret clinical and laboratory findings, therefore improving therapies and prognosis.
Dietary fiber aids in the management of canine and feline gastrointestinal disease
Authors: Moreno Adam A. , Parker Valerie J. , Winston Jenessa A. , Rudinsky Adam J. 
Published: October 2022

Abstract
Dietary fiber describes a diverse assortment of nondigestible carbohydrates that play a vital role in the health of animals and maintenance of gastrointestinal tract homeostasis. The main roles dietary fiber play in the gastrointestinal tract include physically altering the digesta, modulating appetite and satiety, regulating digestion, and acting as a microbial energy source through fermentation. These functions can have widespread systemic effects. Fiber is a vital component of nearly all commercial canine and feline diets. Key features of fiber types, such as fermentability, solubility, and viscosity, have been shown to have clinical implications as well as health benefits in dogs and cats. Practitioners should know how to evaluate a diet for fiber content and the current knowledge on fiber supplementation as it relates to common enteropathies including acute diarrhea, chronic diarrhea, constipation, and hairball management. Understanding the fundamentals of dietary fiber allows the practicing clinician to use fiber optimally as a management modality.
Solid fuel briquette from biomass: Recent trends
Authors: Mohd-Faizal Azrul Nurfaiz , Mohd-Shaid Mohd Shafiq Hakimi , Ahmad-Zaini Muhammad Abbas 
Published: October 2022

Abstract
Solid fuel briquette from biomass materials has gained considerable attention as sustainable replacement source of energy. The characteristics of briquette are imperative to ensure its effectiveness as fuel in a long run. This paper is aimed to summarize the key properties of solid briquette made from various natural and waste-based resources, and to highlight the future research directions in the briquette manufacture. The commentary is expected to shed insight towards the greener, cleaner, and efficient briquette materials.
Transpiration-Cooling Heat Transfer Experiments in Laminar and Turbulent Hypersonic Flows
Authors: Naved Imran , Hermann Tobias , Hambidge Chris , Saad Ifti Hassan , Falsetti Chiara , McGilvray Matthew , Tirichenko Iullia S , Vandeperre Luc 
Published: October 2022

The design of a transpiration-cooled system requires detailed local heat transfer information on and in the vicinity of the porous injector; however, limited spatially resolved experimental studies exist, particularly in hypersonic flows. In this work, experiments were conducted in the University of Oxford’s high-density tunnel at Mach 6.1 in both laminar and turbulent regimes. Spatially resolved two-dimensional surface heat transfer measurements were acquired by imaging directly on and downstream of two microporous transpiration-cooled injectors (METAPOR® CE170 and zirconia) using high-speed infrared thermography. Whereas injection in the laminar regime results in a steady, monotonic reduction in heat transfer from the start of the injector, a flatter profile is present for the turbulent cases where turbulent mixing inhibits surface heat transfer reduction. It was found that a modification to existing relations from film theory successfully correlates the streamwise heat transfer distribution on the injector for different blowing rates of nitrogen and helium. A key result is that helium performs much better than reported in previous experiments. Finally, the downstream thermal effectiveness is characterized for turbulent flows. A collapse of the thermal effectiveness is achieved and a modified analytical correlation proposed.
PENERAPAN MODEL VECTOR AUTOREGRESSIVE ORDE TIGA PADA DATA SUHU UDARA RATA-RATA DI KABUPATEN MALANG DAN KABUPATEN SIDOARJO
Authors: Salsabila Salsabila , Kusuma Dianne Amor , Ruchjana Budi Nurani 
Published: October 2022

Perubahan iklim berdampak sangat luas pada kehidupan masyarakat. Salah satu unsur yang memengaruhi perubahan iklim yaitu suhu udara. Perubahan iklim di beberapa wilayah tidak hanya dipengaruhi oleh satu waktu. Perubahan iklim di suatu wilayah dapat dipengaruhi oleh dua atau tiga waktu sebelumnya. Perubahan iklim dari waktu ke waktu dapat diketahui melalui analisis deret waktu. Penelitian ini bertujuan untuk menaksir parameter model Vector Autoregressive orde tiga (VAR (3)) menggunakan metode Ordinary Least Squares (OLS) serta menerapkan model VAR (3) pada data suhu udara rata-rata di Kabupaten Malang dan Kabupaten Sidoarjo. Nilai peramalan yang diperoleh selama 10 periode telah mendekati nilai aktual dengan nilai MAPE berturut-turut adalah dan . Berdasarkan kriteria nilai MAPE, nilai MAPE menunjukkan hasil peramalan sangat akurat sehingga penelitian ini dapat menjadi bahan referensi bagi lembaga peneliti, perguruan tinggi, maupun peneliti lain dalam menerapkan model VAR (3) pada data suhu udara rata-rata dengan menggunakan bantuan software R.
Adapting International Standards and Ethical Principles to New Reproductive Technologies (NRTs) and Scientific Advances
Authors: Barletta Mariangela 
Published: October 2022

The advancement of new technology raises ethical issues. Among them, human health, especially birth, is more frequently at the center of the discussions. Indeed, new technologies have the potential to radically alter human nature, such as modifying human reproduction. In recent years, it has been demonstrated that new technology can provide maternity surrogacy, as well as gene editing and the possible development of an artificial uterus. The legislative response to these issues is still fragmented and poorly regulated, inhibited by moral arguments as well as legal systems' inability to adapt to decades-old issues like abortion. A lack of permissiveness on the side of some governments is frequently the source of disadvantages. In the case of maternal surrogacy, for example, there are frequently documented cases of abuse and corruption as a result of legislative differences across jurisdictions. Indeed, the potential of surrogacy in certain nations encourages individuals to travel overseas and use artificial insemination treatments that are not authorized under their domestic laws. On the other hand, women who agree to give their uterus are frequently poor and forced to accept. In this regard, it would be ideal if many states could adapt their laws to scientific advancement. Looking ahead, similar harmful trends might be seen in the development of artificial reproductive systems, which has recently received research funding. As a response, the article proposes to look at how the law should adapt to the latest innovative advancements in terms of new reproductive technologies, examining what is now achievable and what could happen in the near future from an ethical perspective.
The Causes of Malnutrition for Pregnant Mothers Analysis and The Impact on the COVID-19 Pandemic
Authors: Yuliarti Yuliarti , Ermi Nurmalia , Arinda Ditia Fitri 
Published: October 2022

Chronic Energy Deficiency (CED), and anemia are malnutrition in pregnant women. The impact is inappropriate maternal weight gain during pregnancy. It causes the babylow birth weight, the risk is greater stunting. Ogan Ilir District designated as a stunting locus by the central Bappenas in 2020. CED and anemia had a significant increase during COVID-19 pandemic in 2019-2020. This research aims to analyze the factors that cause malnutrition in pregnant women and their impact during the COVID-19 pandemic as an effort to prevent stunting. Quantitative study with a cross sectional design used. 99 pregnant women taken by purposive sampling technique. Questionnaires and nutritional status measurements were carried out by measuring (LiLA), hemoglobin levels, and nutritional intake was assessed from food recall 2x24 hours. Data were analyzed using Chi square test. The results show that 13.1% of pregnant women experienced CED, 61.6% anemia, 62.6%, Emesis gravidarum and 44.4% weight gain was not appropriate. There is a relationship between energy intake (p = 0.004, carbohydrates (p = 0.012), the incidence of CED in pregnant women, there is a relationship between Fe intake (p = 0.0001 ) and consumption of TTD (p = 0.003) having anemia. and the impact of malnutrition, There is a relationship between CED (p=0.018) and emesis gravidarum (p=0.003) by weight gain of pregnant women during the COVID-19 pandemic. It is necessary to improve antenatal care services during the COVID-19 pandemic in providing information about fulfilling the nutritional intake of pregnant women so that mothers do not malnutrition.
Feeding of glucomannans and anthocyanins combination in the containing microparticle protein on fat digestibility and fat deposition on broiler chicken
Authors: Krismiyanto Lilik , Suthama Nyoman , Mulyono Mulyono , Ningrum Masrifah Ayu 
Published: October 2022

This study aims to evaluate the effects of combination of glucomannan and anthocyanin in feeds containing protein microparticles on fat digestibility and fat deposition in broiler chickens. The 216 healthy 7-day-old broiler chicks strain CP 707 was used with treatment of glucomannan from porang tuber extract and anthocyanins from purple sweet potato extract. The study was arranged by a completely randomized design (CRD) with a factorial pattern with treatment consisting of 2 factors (A and B). In A, there were 3 glucomannan treatments, A1 (0%), A2 (0.05%) and A3 (0.1%), while in B contained 3 anthocyanin treatments, B1 (0), B2 (0.07%) and B3 (0.14%) with 3 replications. The measure was fat digestibility, precentage of abdominal fat and meat fat mass. The data were analyzed for variance at the 5% level and continued with Duncan's double test at the 5% level. The results showed that the addition of a combination of glucomannan and anthocyanin in the feed containing protein microparticles had an interaction (P<0.05) on fat digestibility, meat fat mass and relative weight of abdominal fat in broiler chickens. The addition of a combination of 0.1% glucomannan and 0.14% anthocyanin (A3B3) in the feed containing microparticle protein was able to reduce fat digestibility, relative abdominal fat weight and meat fat mass in broiler chickens.
Consecuencias del covid-19 ante la salud mental de profesionales de enfermería en un hospital de Guayaquil
Authors: Figueroa Pico Cesar , Castillo Morocho Silvia , Cerezo Leal Betzaida , López Álava Carla Estefanía 
Published: October 2022

La pandemia por COVID-19 causada por el nuevo coronavirus conocido como SARS – CoV-2 capaz de producir sintomatologías leves hasta mortales, tuvo muchas repercusiones en la salud física y en la Salud Mental de la población en general. Durante la lucha contra la pandemia se pudo determinar que uno de los grupos vulnerables o grupos de riesgo fueron y siguen siendo los Profesionales de la Salud ya que al brindar un cuidado directo a pacientes diagnosticados con Covid-19 pueden generar incertidumbre, miedo al contagio, estrés postraumático, insomnio, infelicidad, duelo patológico entre otras causas que puede alterar su estado Mental y también los efectos del confinamiento y pérdida de hábitos y rutinas, el objetivo principal de esta investigación fue determinar los efectos de la pandemia por Covid-19 sobre la salud mental del profesional de enfermería que laboran en un Hospital de Guayaquil, año 2020. Se realizó un estudio de enfoque cuantitativo con un método deductivo y analítico. La población estudio estuvo conformada por 70 profesionales de Enfermería de las áreas de hospitalización, se les realizó una encuesta aplicando el Cuestionario de Salud General de Goldberg (Goldberg General Questionarie - GHQ28), Mediante el análisis e interpretación de los resultados, se pudo evidenciar que el 27,3% de participantes mantienen un Estado Civil Casado, mientras que el Sexo Femenino supera al Masculino con 85,4% sobre un 14,6% respectivamente. Dentro de la clasificación por edades se puede observar que la mayoría corresponde al rango entre 41 – 50 años con un 18,6% seguido del rango entre 25 – 30 años con un 13,6%. Y se determinó que el 37% de la población de estudio presenta alteraciones o posibles alteraciones en su salud mental tales como Cansancio y agotamiento físico, Insomnio o dificultad para dormir, Insatisfacción de las actividades diarias y Depresión Grave, además se pudo identificar ciertos factores de riesgos presentes que pudieron dar cabida a la aparición de las alteraciones antes mencionadas, como: la pérdida de hábitos y rutinas y el deceso perdida de familiares o personas cercanas.
Sistem Antrian Generik Menggunakan Model Single Channel Single Phase
Authors: Brianorman Yulrio , Sucipto Sucipto 
Published: October 2022

Kebutuhan terhadap sistem antrian pada saat ini menjadi hal yang dinilai penting. Studi literatur yang telah dilakukan menunjukkan bahwa sistem antrian yang dikembangkan bersifat spesifik untuk satu proses atau instansi tertentu saja. Oleh karena itu, tujuan dari penelitian ini adalah merancang dan mengembangkan sistem antrian yang dapat digunakan oleh siapapun dengan struktur antrian single-channel single-phase. Metodologi penelitian menggunakan design science research. Rancangan sistem antrian telah dibangun menjadi sebuah aplikasi berbasis website dengan nama tabarun.com. Kelebihan dari sistem ini yang juga menjadi kontribusi dalam penelitian adalah sistem antrian ini dapat digunakan oleh siapapun, antar pengguna sistem dapat menjadi follower/following dengan pengguna lainnya. Evaluasi pada sistem ini telah dilakukan black box yang memberikan hasil pengujian valid pada semua proses pengujian yang dilakukan. Selain itu juga dilakukan user acceptance test pada aspek aksesibilitas, aspek fungsional, dan aspek komunikasi visual. Secara keseluruhan, hasil pengujian menunjukkan bahwa sistem telah diterima dengan baik oleh pengguna.
Using Subject Positioning Theory to Investigate Reading Engagement among University Students
Authors: Abu Hassan Salmah Anisah , Ahmad Norkhairi Bin 
Published: October 2022

This study sets out to investigate the magnitude of reading engagement by technical engineering undergraduates. Purposive samples in the form of six bachelor’s degree students were chosen based on the observed active roles as class representatives and as active learners in the English course that they have previously taken. Two chapters from a compulsory textbook of a mandatory course from the undergraduates’ programme called Innovation Management were chosen to explore their subject positioning and reading engagement aspect. The undergraduates were requested to activey read, interact and scribble notes if necessary during reading while their engagement via think aloud protocol were recorded. The recordings were transcribed and analysed for evidence of subject positioning and knowledge processing with inter rater and expert verifications on the identified themes. The findings show that the uundergraduates actively undertake subject positioning to align and disalign with subject matter materials and information put forth by the author of the textbook as evidence of moderate to active reading engagement and knowledge processing. Input from previous reading, general knowldge, current experience and previous work experience intertwine in functioning as sources of the subject positioning and knowledge processing during the reading engagements. The findings are significant in raising awareness among educators on the need to cultivate active reading engagement and to devise training for undergraduates on strategies for active reading engagement. These recommended efforts from this study will yield great benefits for undergraduates in their learning curve at the academia.
Development of acceptance criteria for the results of anti-D IgG quantification in human anti-D (Rh<sub>о</sub>) immunoglobulin preparations by enzyme immunoassay
Authors: Shvedova E. V. , Leshina S. A. , Kudasheva E. Yu. , Borisevich I. V. , Merkulov V. A. , Shvedov D. V. 
Published: October 2022

The competitive enzyme-linked immunosorbent assay (ELISA) used for the quantification of specific antibodies, anti-D (Rho) IgGs, in human anti-D (Rho) immunoglobulin preparations relies upon the competition between anti-D antibodies in the preparation and anti-D monoclonal antibodies (mAbs) for immunochemical binding to D-antigen epitopes of the immunosorbent, human erythrocytes of the ccDEE phenotype immobilised on a solid support. The immunosorbent is prepared in-house under laboratory conditions. The certification of the International Standard (IS) for anti-D immunoglobulin included attempts to use the CCDee phenotype, which is more common (16.01%) than the ccDEE phenotype (2.16%). It is possible to use the CCDee phenotype, as long as the user adheres to the acceptance criteria for the results, developed during method validation. The aim of this study was to develop the acceptance criteria for the results of anti-D IgG quantification in human anti-D immunoglobulin preparations by the ELISA method that would allow using CCDee erythrocytes to prepare the immunosorbent should there be no erythrocytes of the ccDEE phenotype available. Materials and methods: the study used human anti-D immunoglobulin preparations; anti-D IgG–spiked samples; the IS for anti-D immunoglobulin; the reference standard (RS) for anti-D IgG–free immunoglobulin; anti-D mAbs; and erythrocytes of the CCDee, ccDEE, and ccddee phenotypes. The authors quantified anti-D IgG antibodies by the competitive ELISA. The statistical analysis used parametric and nonpar ametric tests. Results: the study demonstrated the possibility of using CCDee erythrocytes for competitive immunochemical binding with anti-D mAbs and anti-D IgG of various human anti-D immunoglobulin preparations. The suitability of the analytical procedure with the CCDee phenotype was confirmed by validation parameters: trueness, intermediate precision, linearity, selectivity, specificity, and robustness of the method and comparability of the results obtained when using the CCDee and ccDEE phenotypes. The authors developed the acceptance criteria: the relative values of anti-D IgG content in the test sample should range within ±20% of the nominal value; the coefficient of determination (R2) should be at least 0.9; the relative standard deviation (RSD, %) of three absorbance values for each concentration should not exceed 20%. Conclusions: these acceptance criteria guarantee the reliability of assay results of anti-D IgG quantification by the ELISA, which allows them to be used by specialists of control and analytical laboratories to assess the quality of human anti-D immunoglobulin preparations.
Optimisation of culture conditions for a producer clone coexpressing arylsulfatase B and a formylglycine-generating enzyme in order to increase the yield of arylsulfatase B
Authors: Timonova S. S. , Smolova K. A. , Kirik I. A. , Pantyushenko M. S. , Anisimov R. L. , Khamitov R. A. , Piskunov A. A. , Bade V. N. 
Published: October 2022

Maroteaux—Lamy syndrome (mucopolysaccharidosis type VI) is an orphan genetic disease caused by mutations in the arylsulfatase B gene (ARSB), which encodes the lysosomal enzyme arylsulfatase B (ASB). The relevance of the study lies in the need of a Russian recombinant ASB product for patients with the disease in the Russian Federation. Previously, the authors have developed producer lines coexpressing the target ASB enzyme with an auxiliary formylglycine-generating enzyme (FGE), based on Chinese hamster ovary (CHO) cells. Further development of the recombinant ASB preparation places priority on increasing the enzyme yield. The aim of this study was to increase the productivity of producer clones by optimising the culture process and adding calcium chloride and copper sulfate to the culture medium. Materials and methods: a suspension-adapted CHO cell line was used. Monoclonal cell lines were developed using Cell Metric and ClonePix FL systems. The concentration of ASB in the culture liquid was determined using the enzyme-linked immunosorbent assay (ELISA). The authors analysed batch culture and/or fed-batch culture in media supplemented with various concentrations of copper sulfate and calcium chloride. Results: the combined addition of copper sulfate and calcium chloride at concentrations of 300 μM during batch culture of producer clones coexpressing ASB and FGE increases viability and specific productivity of the cells up to 4.58±1.62 pg/ (cell×day). The cultivation of the lead producer clone coexpressing ASB and FGE under fed-batch conditions for 12 days and the addition of copper sulfate to the growth medium at the concentration of 300 μM allow for increasing the yield of the active lysosomal enzyme, arylsulfatase B, to 420 mg/L. Conclusions: the cultivation of producer clones coexpressing ASB and FGE under fed-batch conditions with copper sulfate added to the medium significantly improves cell line growth properties and the ASB yield. This approach to the selection of culture conditions for producer cell lines can be applied to other enzymes of the sulfatase family.