bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of policies in transforming regional fiscal structures: an exploratory analysis of spatial data from a policy of fiscal decentralization in Latin America
Authors: Fernández-Marín Juan Camilo , de Oliveira Nadja Simone Menezes Nery , Mourao Paulo 
Published: August 2022

AbstractOne of the goals of decentralized policies is to consider the differences between regions and municipalities, which can lead to greater economic growth as well as greater economic development in all areas. However, endogenous limitations should also be overcome. For these purposes, policies have been designed and must therefore be evaluated in terms of the consequences. One of the most ambitious policies in Latin America in recent years has been the implementation of the ‘General Regalías system’ in Colombia. This paper will assess whether this policy has led to significant changes in the fiscal performance of the municipalities in the Valle del Cauca region, in which the most important city is Cali. We found that this policy was not able to change the ‘neighborhood contagion’ observed before implementation. This is an important conclusion of the study, which includes the spatial dependence to explain the fiscal performance of the municipalities. Through an exploratory analysis of spatial data (AEDE), we verified that the referenced system failed to reach its most ambitious objectives, raising the need for another type of public policy instrument.
Consumer preferences for wild game meat: evidence from a hybrid choice model on wild boar meat in Italy
Authors: Fantechi Tommaso , Contini Caterina , Scozzafava Gabriele , Casini Leonardo 
Published: August 2022

AbstractThe increasing numbers of wild animals in Europe is leading, on the one hand, to growing problems stemming from their interaction with human activities. On the other, many European countries have still not developed national supply chains to market wild game. Instead, these supply chains could represent a win–win strategy in providing a sustainable alternative to production via intensive livestock farming and developing rural territories. Our aim was to understand consumer behaviour towards wild game meat. We conducted a choice experiment on wild boar meat on a sample of Italian consumers (625). The application of a hybrid model combining a structural equation model and a latent class analysis allowed us to identify the antecedents of attitude towards wild game meat and to analyse consumer choices by utilising attitude as an explanatory variable. The results provide useful suggestions to implement rural development policies and offer food for thought in the area of consumer behaviour.
Dominant changes in the breast muscle lipid profiles of broiler chickens with wooden breast syndrome revealed by lipidomics analyses
Authors: Liu Ranran , Kong Fuli , Xing Siyuan , He Zhengxiao , Bai Lu , Sun Jiahong , Tan Xiaodong , Zhao Di , Zhao Guiping , Wen Jie 
Published: August 2022

Abstract
Background
Chicken is the most consumed meat worldwide and the industry has been facing challenging myopathies. Wooden breast (WB), which is often accompanied by white striping (WS), is a serious myopathy adversely affecting meat quality of breast muscles. The underlying lipid metabolic mechanism of WB affected broilers is not fully understood.

Results
A total of 150 chickens of a white-feathered, fast-growing pure line were raised and used for the selection of WB, WB + WS and control chickens. The lipids of the breast muscle, liver, and serum from different chickens were extracted and measured using ultra performance liquid chromatography (UPLC) plus Q-Exactive Orbitrap tandem mass spectrometry. In the breast, 560 lipid molecules were identified. Compared to controls, 225/225 of 560 lipid molecules (40.2%) were identified with differential abundance (DA), including 92/100 significantly increased neutral lipids and 107/98 decreased phospholipids in the WB/WB + WS groups, respectively. The content of monounsaturated fatty acids (MUFA) was significantly higher, and the polyunsaturated fatty acids (PUFA) and saturated fatty acids (SFA) were significantly lower in the affected breasts. In the liver, 434 lipid molecules were identified, and 39/61 DA lipid molecules (6.7%/14.1%) were detected in the WB and WB + WS groups, respectively. In the serum, a total of 529 lipid molecules were identified and 4/44 DA lipid molecules (0.8%/8.3%) were detected in WB and WB + WS group, respectively. Compared to controls, the content of MUFAs in the serum and breast of the WB + WS group were both significantly increased, and the content of SFAs in two tissues were both significantly decreased. Only five lipid molecules were consistently increased in both liver and serum in WB + WS group.

Conclusions
We have found for the first time that the dominant lipid profile alterations occurred in the affected breast muscle. The relative abundance of 40.2% of lipid molecules were changed and is characteristic of increased neutral lipids and decreased phospholipids in the affected breasts. Minor changes of lipid profiles in the liver and serum of the affected groups were founded. Comprehensive analysis of body lipid metabolism indicated that the abnormal lipid profile of WB breast may be independent of the liver metabolism.
Critical aspiration pneumonia during induction of anesthesia in elective abdominal surgery: a case report
Authors: Mogami Midori , Yamazaki Yuki , Nemoto Chiaki , Muto Mariko , Tanaka Youichi , Inoue Satoki 
Published: August 2022

Abstract
Background
We experienced the critical aspiration pneumonia during induction of anesthesia in elective abdominal surgery which standard fasting period was complied with.

Case presentation
A 64-year-old male was scheduled for gastrojejunostomy because of gastrointestinal obstruction. He fasted from the night before surgery. General anesthesia was induced, and cricoid pressure was applied during intubation. However, he vomited huge amount of gastric contents. The scheduled surgery was performed without surgical complications, and postoperatively respiratory management, including mechanical ventilation with prone positioning, was performed in high care unit. He was extubated on postoperative day 2. He was discharged from the hospital on POD 25.

Conclusion
The standard fasting period can prevent aspiration pneumonia in most cases. However, even in elective cases without abdominal symptoms, we consider that massive-volume gastric residual contents, especially in susceptible cases. We suggest that point-of-care gastric ultrasonography be performed in suspicious cases before induction of anesthesia.
Typing expertise in a large student population
Authors: Pinet Svetlana , Zielinski Christelle , Alario F.-Xavier , Longcamp Marieke 
Published: August 2022

AbstractTyping has become a pervasive mode of language production worldwide, with keyboards fully integrated in a large part of many daily activities. The bulk of the literature on typing expertise concerns highly trained professional touch-typists, but contemporary typing skills mostly result from unconstrained sustained practice. We measured the typing performance of a large cohort of 1301 university students through an online platform and followed a preregistered plan to analyse performance distributions, practice factors, and cognitive variables. The results suggest that the standard model with a sharp distinction between novice and expert typists may be inaccurate to account for the performance of the current generation of young typists. More generally, this study shows how the mere frequent use of a new tool can lead to the incidental development of high expertise.
A soft actor-critic deep reinforcement learning method for multi-timescale coordinated operation of microgrids
Authors: Hu Chunchao , Cai Zexiang , Zhang Yanxu , Yan Rudai , Cai Yu , Cen Bowei 
Published: August 2022

AbstractThis paper develops a multi-timescale coordinated operation method for microgrids based on modern deep reinforcement learning. Considering the complementary characteristics of different storage devices, the proposed approach achieves multi-timescale coordination of battery and supercapacitor by introducing a hierarchical two-stage dispatch model. The first stage makes an initial decision irrespective of the uncertainties using the hourly predicted data to minimize the operational cost. For the second stage, it aims to generate corrective actions for the first-stage decisions to compensate for real-time renewable generation fluctuations. The first stage is formulated as a non-convex deterministic optimization problem, while the second stage is modeled as a Markov decision process solved by an entropy-regularized deep reinforcement learning method, i.e., the Soft Actor-Critic. The Soft Actor-Critic method can efficiently address the exploration–exploitation dilemma and suppress variations. This improves the robustness of decisions. Simulation results demonstrate that different types of energy storage devices can be used at two stages to achieve the multi-timescale coordinated operation. This proves the effectiveness of the proposed method.
Cannabis consumption is associated with lower COVID-19 severity among hospitalized patients: a retrospective cohort analysis
Authors: Shover Carolyn M. , Yan Peter , Jackson Nicholas J. , Buhr Russell G. , Fulcher Jennifer A. , Tashkin Donald P. , Barjaktarevic Igor 
Published: August 2022

Abstract
Background
While cannabis is known to have immunomodulatory properties, the clinical consequences of its use on outcomes in COVID-19 have not been extensively evaluated. We aimed to assess whether cannabis users hospitalized for COVID-19 had improved outcomes compared to non-users.

Methods
We conducted a retrospective analysis of 1831 patients admitted to two medical centers in Southern California with a diagnosis of COVID-19. We evaluated outcomes including NIH COVID-19 Severity Score, need for supplemental oxygen, ICU (intensive care unit) admission, mechanical ventilation, length of hospitalization, and in-hospital death for cannabis users and non-users. Cannabis use was reported in the patient’s social history. Propensity matching was used to account for differences in age, body-mass index, sex, race, tobacco smoking history, and comorbidities known to be risk factors for COVID-19 mortality between cannabis users and non-users.

Results
Of 1831 patients admitted with COVID-19, 69 patients reported active cannabis use (4% of the cohort). Active users were younger (44 years vs. 62 years, p < 0.001), less often diabetic (23.2% vs 37.2%, p < 0.021), and more frequently active tobacco smokers (20.3% vs. 4.1%, p < 0.001) compared to non-users. Notably, active users had lower levels of inflammatory markers upon admission than non-users—CRP (C-reactive protein) (3.7 mg/L vs 7.6 mg/L, p < 0.001), ferritin (282 μg/L vs 622 μg/L, p < 0.001), D-dimer (468 ng/mL vs 1140 ng/mL, p = 0.017), and procalcitonin (0.10 ng/mL vs 0.15 ng/mL, p = 0.001). Based on univariate analysis, cannabis users had significantly better outcomes compared to non-users as reflected in lower NIH scores (5.1 vs 6.0, p < 0.001), shorter hospitalization (4 days vs 6 days, p < 0.001), lower ICU admission rates (12% vs 31%, p < 0.001), and less need for mechanical ventilation (6% vs 17%, p = 0.027). Using propensity matching, differences in overall survival were not statistically significant between cannabis users and non-users, nevertheless ICU admission was 12 percentage points lower (p = 0.018) and intubation rates were 6 percentage points lower (p = 0.017) in cannabis users.

Conclusions
This retrospective cohort study suggests that active cannabis users hospitalized with COVID-19 had better clinical outcomes compared with non-users, including decreased need for ICU admission or mechanical ventilation. However, our results need to be interpreted with caution given the limitations of a retrospective analysis. Prospective and observational studies will better elucidate the effects cannabis use in COVID-19 patients.
Gut microbiome reflect adaptation of earthworms to cave and surface environments
Authors: Gong Xin , Chen Ting-Wen , Zhang Lili , Pižl Václav , Tajovský Karel , Devetter Miloslav 
Published: August 2022

Abstract
Background
Caves are special natural laboratories for most biota and the cave communities are unique. Establishing population in cave is accompanied with modifications in adaptability for most animals. To date, little is known about the survival mechanisms of soil animals in cave environments, albeit they play vital roles in most terrestrial ecosystems. Here, we investigated whether and how gut microbes would contribute to the adaptation of earthworms by comparing the gut microbiome of two earthworm species from the surface and caves.

Results
Two dominant earthworm species inhabited caves, i.e., Allolobophora chlorotica and Aporrectodea rosea. Compared with the counterparts on the surface, A. rosea significantly decreased population in the cave, while A. chlorotica didn’t change. Microbial taxonomic and phylogenetic diversities between the earthworm gut and soil environment were asynchronic with functional diversity, with functional gene diversity been always higher in earthworm gut than in soil, but species richness and phylogenetic diversity lower. In addition, earthworm gut microbiome were characterized by higher rrn operon numbers and lower network complexity than soil microbiota.

Conclusions
Different fitness of the two earthworm species in cave is likely to coincide with gut microbiota, suggesting interactions between host and gut microbiome are essential for soil animals in adapting to new environments. The functional gene diversity provided by gut microbiome is more important than taxonomic or phylogenetic diversity in regulating host adaptability. A stable and high-efficient gut microbiome, including microbiota and metabolism genes, encoded potential functions required by the animal hosts during the processes of adapting to and establishing in the cave environments. Our study also demonstrates how the applications of microbial functional traits analysis may advance our understanding of animal-microbe interactions that may aid animals to survive in extreme ecosystems.
Revisiting imaging features of rectosigmoid vascular malformation with emphasis on multiparametric MRI: a case report
Authors: Erdemli S. , Alis D. , Çiçek B. , Göksel S. , Karahasanoğlu T. , Karaarslan E. 
Published: August 2022

Abstract
Background
Gastrointestinal vascular malformations are rare benign vascular neoplasms of the gastrointestinal tract, with the rectosigmoid region being the most frequently involved site. Patients often manifest with recurrent, intermittent rectal bleeding, which might occasionally be life-threatening.

Case presentation
A 39-year-old man with a history of hemorrhoid operations twice was presented to our gastroenterology department with blood in the stool and abdominal pain. After the colonoscopy, multiparametric MRI, and CT examinations, robotic low anterior resection was performed with the diagnosis of rectosigmoid venous malformation. The histopathological examination confirmed the diagnosis.

Conclusion
Colonoscopy is the preferred method in diagnosing rectosigmoid vascular malformation, but wrong and delayed diagnoses are common. Thus, imaging modalities might add to colonoscopy in equivocal cases.
Palliative care models for patients living with advanced cancer: a narrative review for the emergency department clinician
Authors: Grudzen Corita R. , Barker Paige C. , Bischof Jason J. , Cuthel Allison M. , Isaacs Eric D. , Southerland Lauren T. , Yamarik Rebecca L. 
Published: August 2022

AbstractEighty-one percent of persons living with cancer have an emergency department (ED) visit within the last 6 months of life. Many cancer patients in the ED are at an advanced stage with high symptom burden and complex needs, and over half is admitted to an inpatient setting. Innovative models of care have been developed to provide high quality, ambulatory, and home-based care to persons living with serious, life-limiting illness, such as advanced cancer. New care models can be divided into a number of categories based on either prognosis (e.g., greater than or less than 6 months), or level of care (e.g., lower versus higher intensity needs, such as intravenous pain/nausea medication or frequent monitoring), and goals of care (e.g., cancer-directed treatment versus symptom-focused care only). We performed a narrative review to (1) compare models of care for seriously ill cancer patients in the ED and (2) examine factors that may hasten or impede wider dissemination of these models.
Partial Breast Irradiation Versus Whole Breast Irradiation for Early Breast Cancer Patients in a Randomized Phase III Trial: The Danish Breast Cancer Group Partial Breast Irradiation Trial
Authors: Offersen Birgitte V. , Alsner Jan , Nielsen Hanne M. , Jakobsen Erik H. , Nielsen Mette H. , Stenbygaard Lars , Pedersen Anders N. , Thomsen Mette S. , Yates Esben , Berg Martin , Lorenzen Ebbe L. , Jensen Ingelise , Josipovic Mirjana , Jensen Maj-Britt , Overgaard Jens ,   on behalf of the Danish Breast Cancer Group Radiotherapy Committee
Published: August 2022

PURPOSE On the basis of low risk of local recurrence in elderly patients with breast cancer after conservative surgery followed by whole breast irradiation (WBI), the Danish Breast Cancer Group initiated the noninferiority external-beam partial breast irradiation (PBI) trial (ClinicalTrials.gov identifier: NCT00892814 ). We hypothesized that PBI was noninferior to WBI regarding breast induration. METHODS Patients operated with breast conservation for relatively low-risk breast cancer were randomly assigned to WBI versus PBI, and all had 40 Gy/15 fractions. The primary end point was 3-year grade 2-3 breast induration. RESULTS In total, 865 evaluable patients (434 WBI and 431 PBI) were enrolled between 2009 and 2016. Median follow-up was 5.0 years (morbidity) and 7.6 years (locoregional recurrence). The 3-year rate of induration was 9.7% for WBI and 5.1% for PBI ( P = .014). Large breast size was significantly associated with induration with a 3-year incidence of 13% (WBI) and 6% (PBI) for large-breasted patients versus 6% (WBI) and 5% (PBI) for small-breasted patients. PBI showed no increased risk of dyspigmentation, telangiectasia, edema, or pain, and patient satisfaction was high. Letrozole and smoking did not increase the risk of radiation-associated morbidity. Sixteen patients had a locoregional recurrence (six WBI and 10 PBI; P = .28), 20 patients had a contralateral breast cancer, and eight patients had distant failure (five WBI and three PBI). A nonbreast second cancer was detected in 73 patients (8.4%), and there was no difference between groups. CONCLUSION External-beam PBI for patients with low-risk breast cancer was noninferior to WBI in terms of breast induration. Large breast size was a risk factor for radiation-associated induration. Few recurrences were detected and unrelated to PBI.
Racial and Ethnic Health Disparities in Delay to Initiation of Intensity-Modulated Radiotherapy
Authors: Hutten Ryan J. , Weil Christopher R. , Gaffney David K. , Kokeny Kristine , Lloyd Shane , Rogers Charles R. , Suneja Gita 
Published: August 2022

PURPOSE:Delays in initiation of radiotherapy may contribute to inferior oncologic outcomes that are more commonly observed in minoritized populations in the United States. We aimed to examine inequities associated with delayed initiation of intensity-modulated radiotherapy (IMRT).MATERIALS AND METHODS:The National Cancer Database was queried to identify the 10 cancer sites most commonly treated with IMRT. Interval to initiation of treatment (IIT) was broken into quartiles for each disease site, with the 4thquartile classified as delayed. Multivariable logistic regression for delayed IIT was performed for each disease site using clinical and demographic covariates. Differences in magnitude of delay between subsets of patients stratified by race and insurance status were evaluated using two-sample t-tests.RESULTS:Among patients (n = 350,425) treated with IMRT between 2004 and 2017, non-Hispanic Black (NHB), Hispanic, and Asian patients were significantly more likely to have delayed IIT with IMRT for nearly all disease sites compared with non-Hispanic White (NHW) patients. NHB, Hispanic, and Asian patients had significantly longer median IIT than NHW patients (NHB 87 days, P < .01; Hispanic 76 days, P < .01; Asian 74 days, P < .01; and NHW 67 days). NHW, Hispanic, and Asian patients with private insurance had shorter median IIT than those with Medicare ( P < .01); however, NHB patients with private insurance had longer IIT than those with Medicare ( P < .01).CONCLUSION:Delays in initiation of IMRT in NHB, Hispanic, and Asian patients may contribute to the known differences in cancer outcomes and warrant further investigation, particularly to further clarify the role of different insurance policies in delays in advanced modality radiotherapy.
Effects of Wnt-β-Catenin Signaling and Sclerostin on the Phenotypes of Rat Pheochromocytoma PC12 Cells
Authors: Morimoto Eisaku , Inagaki Kenichi , Komatsubara Motoshi , Terasaka Tomohiro , Itoh Yoshihiko , Fujisawa Satoshi , Sasaki Erika , Nishiyama Yuki , Hara Takayuki , Wada Jun 
Published: August 2022

Abstract
Pheochromocytomas and paragangliomas (PPGLs) are classified into 3 major categories with distinct driver genes: pseudohypoxia, kinase signaling, and Wnt-altered subtypes. PPGLs in the Wnt-altered subtype are sporadic and tend to be aggressive with metastasis, where somatic gene fusions affecting mastermind-like 3 (MAML3) and somatic mutations in cold shock domain containing E1 (CSDE1) cause overactivation of Wnt-β-catenin signaling. However, the relation between Wnt-β-catenin signaling and the biological behavior of PPGLs remains unexplored. In rat pheochromocytoma PC12 cells, Wnt3a treatment enhanced cell proliferation and suppressed mRNA expression of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis, and dopamine secretion. We identified the expression of sclerostin in PC12 cells, which is known as an osteocyte-derived negative regulator for Wnt signaling-driven bone formation. Inhibition of endogenous Wnt pathway by XAV939 or sclerostin resulted in attenuated cell proliferation and increased TH expression. Furthermore, Wnt3a pretreatment suppressed bone morphogenetic protein (BMP)-induced Smad1/5/9 phosphorylation whereas BMPs enhanced sclerostin expression in PC12 cells. In the Wnt-altered subtype, the increased Wnt-β-catenin pathway may contribute the aggressive clinical behavior with reduced catecholamine production. Furthermore, upregulated expression of sclerostin by BMPs may explain the osteolytic metastatic lesions observed in metastatic PPGLs.
Herculean Unproductivity in Pasolini's La ricotta and Teorema
Authors: Velásquez Juan C. 
Published: August 2022

Abstract
This article examines the relationship between work, capitalist productivity, and the filmmaking practice of Pier Paolo Pasolini. This article examines how Pasolini's La ricotta and Teorema represent an interruption of labor and a contestation of the disciplining mechanisms that compel workers to work. Recuperating Jean-François Lyotard's concept of acinema, this inquiry suggests that Pasolini creates scenes that oppose the capitalist work ethic through formal techniques associated with immobility and contingency. It deploys Hannah Arendt's concept of action and Jacques Rancière's dissensus to describe workers’ political actions in these films as gestures where they shed their identity as workers to enjoy life as humans. The purpose of this intervention is to reframe academic debates of anticapitalism around workers’ desire not to work. Pasolini's films give viewers images that highlight workers’ unproductive potentials, thereby giving them examples of immobile, nonwork dissensual actions, or Herculean unproductivity.