bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spoligotyping of Clinical Isolates of Mycobacterium tuberculosis Complex Species in the Oromia Region of Ethiopia
Authors: Hussien Bedru , Zewude Aboma , Wondale Biniam , Hailu Awraris , Ameni Gobena 
Published: March 2022

BackgroundTuberculosis (TB) is a leading cause of morbidity and mortality in Ethiopia. Investigation of the Mycobacterium tuberculosis complex (MTBC) species circulating in the Ethiopian population would contribute to the efforts made to control TB in the country. Therefore, this study was conducted to investigate the MTBC species and spoligo patterns in the Oromia region (central) of Ethiopia.MethodsA cross-sectional study design was used to recruit 450 smear positive pulmonary TB (PTB) cases from the Oromia region between September 2017 and August 2018. Mycobacteria were isolated from sputum samples on the Lowenstein Jensen (LJ) medium. Molecular identification of the isolates was performed by spoligotyping. The results of spoligotyping were transferred into a query box in the SITVIT2 database and Run TB-Lineage in the TB Insight website for the identification of spoligo international type (SIT) number and linages of the isolates, respectively. Statistical Product and Service Solutions (SPSS) 20 was applied for statistical analysis.ResultsThree hundred and fifteen isolates were grouped under 181 different spoligotype patterns. The most dominantly isolated spoligotype pattern was SIT149 and it consisted of 23 isolates. The majority of the isolates were grouped under Euro-American (EA), East-African-Indian (EAI), and Indo-Oceanic (IO) lineages. These lineages consisted of 79.4, 9.8, and 9.8% of the isolates, respectively. One hundred and sixty-five of the isolates were classified under 31 clustered spoligotypes whereas the remaining 150 were singleton types. Furthermore, 91.1% of the total isolates were classified as orphan types. Clustering of spoligotypes was associated (p &lt; 0.001) with EAI lineage.ConclusionSIT149 and EA lineage were predominantly isolated from the Oromia region substantiating the findings of the similar studies conducted in other regions of Ethiopia. The observation of significant number of singleton and orphan spoligotypes warrants for additional genetic typing of the isolates using method(s) with a better discriminatory power than spoligotyping.
Exploring and Developing a New Culturally-Appropriate Diabetes Distress Scale in Taiwan
Authors: Lin Ching-Ling , Chang Yao-Tsung , Liu Wen-Cheng , Huang Li-Chi , Tsao Shin-Yi , Chen Yu-Hsin , Chen Ruey-Yu 
Published: March 2022

IntroductionThe aim of this study was to develop and validate a new diabetes distress scale suitable for Chinese and Taiwanese culture.MethodsThis study collected the current diabetes distress measurement tools, re-organized current definitions about the domains of diabetes distress, and then developed a new tool. Three hundred and ninety-five participants from four hospitals in northern Taiwan were recruited by cluster randomized sampling for validity test.ResultsWe found the new diabetes distress scale had appropriate reliability and validity, including an acceptable model fit for the 12-item scale.ConclusionsThis new diabetes distress scale might be more directly related to emotional distress issues blood glucose control, improve the clinical conspicuity of diabetes distress, and even benefit the overall care of diabetic patients in Taiwan. Further studies about the validity and reliability of this new tool in a nationwide setting are needed.
A Decision Support System for Diagnosing Diabetes Using Deep Neural Network
Authors: Rabie Osama , Alghazzawi Daniyal , Asghar Junaid , Saddozai Furqan Khan , Asghar Muhammad Zubair 
Published: March 2022

Background and ObjectiveAccording to the WHO, diabetes mellitus is a long-term condition marked by high blood sugar levels. The consequences might be far-reaching. According to current increases in mortality, diabetes has risen to number 10 among the leading causes of mortality worldwide. When used to predict diabetes using unbalanced datasets from testing, machine learning (ML) classifiers and established approaches for encoding categorical data have exhibited a broad variety of surprising outcomes. Early studies also made use of an artificial neural network to extract features without obtaining a grasp of the sequence information.MethodsThis study offers a deep learning-based decision support system (DSS), utilizing bidirectional long/short-term memory (BiLSTM), to accurately predict diabetic illness from patient data. In order to predict diabetes, the BiLSTM hybrid model was used after balancing the data set.ResultsUnlike earlier studies, this proposed model's trial findings were promising, with an accuracy of 93.07%, 93% precision, 92% recall, and a 92% F1-score.ConclusionsUsing a BILSTM model for classification outperforms current approaches in the diabetes detection domain.
An Expanded Three Band Model to Monitor Inland Optically Complex Water Using Geostationary Ocean Color Imager (GOCI)
Authors: Guo Yulong , Huang Changchun , Li Yunmei , Du Chenggong , Li Yuan , Chen Weiqiang , Shi Lingfei , Ji Guangxing 
Published: March 2022

Due to strict spectral band requirements, the three-band (TB) chlorophyll-a concentration (Cchla) estimation algorithm cannot be applied to GOCI image, which has great potential in frequently monitoring inland complex waters. In this study, the TB algorithm was expanded and applied to GOCI data. The GOCI TB algorithm was subsequently calibrated using an in-situ dataset which contains 281 samples collected from 17 inland lakes in China between 2013 and 2020. MERIS TB and GOCI band ratio (BR) models were selected as comparisons to assess the proposed model. The results showed that the proposed GOCI TB model has similar accuracy with MERIS TB model and overperformed GOCI BR model. The root mean square error (RMSE) of the GOCI TB, MERIS TB, and GOCI BR algorithms are 14.212 μg/L, 12.096 μg/L, and 20.504 μg/L, respectively. The mean absolute percentage error (MAPE) (when Cchla is larger than 10 μg/L) of the three models were 0.377, 0.250, and 0.453, respectively. Similar conclusion could be drawn from a match-up dataset containing 40 samples. Finally, a simulation experiment was carried out to analyze the robustness of the models under various total suspended matter concentration (CTSM) conditions. Both the in-situ validation and simulation experiment indicated that the GOCI TB factor could effectively eliminate the optical influence of CTSM. Furthermore, the broader spectral range requirement of GOCI TB model made it proper for many other multispectral sensors such as Sentinel two Multispectral Instrument (S2 MSI), Moderate Resolution Imaging Spectroradiometer (MODIS) (onboard the Terra/Aqua satellite), and Visible Infrared Imaging Radiometer Suite (VIIRS) (onboard the National Polar-orbiting Partnership satellite). Compared with the GOCI BR algorithm, the GOCI TB algorithm has stronger stability, better accuracy, and greater potential in practice.
Equine Umbilical Cord Serum Composition and Its Healing Effects in Equine Corneal Ulceration
Authors: Peyrecave-Capo Xavier , Saulnier Nathalie , Maddens Stéphane , Gremillet Bérengère , Desjardins Isabelle 
Published: March 2022

BackgroundHuman autologous serum (AS) and umbilical cord serum (UCS) both contain growth and neurotrophic factors that promote corneal healing.AimOur objectives were to compare equine AS and UCS cytokine and growth factor profiles and to assess the safety and clinical feasibility of the therapeutic use of UCS eye drops in cases of spontaneous complex ulcers.Study DesignProspective clinical trial.MethodsVitamin A insulin growth factor, platelet-derived growth factor-BB, transforming growth factor (TGF)-β1 (enzyme-linked immunosorbent assay), interleukin (IL)-1β, IL-6, interferon-γ, and monocyte chemoattractant protein 1 concentrations were determined in 10 AS collected from different horses and 10 UCS sampled at delivery. Six client-owned horses presenting with complex non-healing corneal defects of &gt;5 mm2 were included in a clinical trial and treated with conventional therapy and conditioned UCS drops for 8–15 days. Ulcer surface and time to complete epithelialization were recorded.ResultsMedian concentrations of vitamin A, insulin growth factor, and platelet-derived growth factor-BB were not significantly different in AS compared with UCS (respectively, 14.5 vs. 12.05 μg/ml; 107.8 vs. 107.3 pg/ml; and 369.1 vs. 924.2 pg/ml). TGF-β1 median concentration in UCS was significantly higher than in AS (3,245 vs. 2571pg/ml) (p = 0.04). IL-1β, IL-6, interferon-γ, and monocyte chemoattractant protein 1 concentrations were variable in AS and undetectable in UCS. The corneal median ulcerative area was 37.2 mm2 (6.28–57.14 mm2) and had a duration of 4–186 days (median 19 days). All lesions healed within 13–42 days (median 17 days). No adverse effects nor recurrences within 1 month were noticed.LimitationsThe sample size was small. Spontaneous corneal epithelial defects presented with variable clinical characteristics. There were no age-matched control horses to assess corneal healing time and rate.Conclusion and Clinical SignificanceEquine UCS may be beneficial, as it contains no pro-inflammatory cytokines and a greater concentration of TGF-β1 compared with AS. Topical UCS appears safe and may potentially be used as adjunctive therapy for equine complex non-healing ulcers.
Does Social Pension Expansion Relieve Depression and Decrease Medical Costs? Evidence From the Rural Elderly in China
Authors: Zhou Mi , Sun Xiaotong , Huang Li 
Published: March 2022

Objectives: This study was designed to explore the effect of the New Rural Pension Scheme on depressive symptoms or medical costs induced by depression.Methods: We used the Logit, OLS and 2SLS models to explore the impact of the pension on depression and medical costs. We also adopt the method of quantile regression and discontinuity regression to verify the causal relationship between the New Rural Pension Scheme and depression or medical costs induced by depression of the rural elderly.Results: We have found that the New Rural Pension Scheme decreases depressive symptoms of elderly in rural China (OR = 0.90), and the medical costs induced by depressive symptoms by 4.6%. Regression discontinuity results showed that pension significantly reduced the depressive symptoms (depression) and the medical expenditure caused by depressive symptoms (depression) by using parametric and non-parametric methods, and performing a placebo test. The mediating effect results showed that pension may improve mental health by increasing confidence about the future.Conclusion: We demonstrate that the pension significantly decreased both mental health problems and the medical expenses due to depressive symptoms and depression of elderly in rural China. Therefore, our results suggest that the Chinese government should perfect the New Rural Pension Scheme to eliminate barriers to mental health resources, especially for the rural elderly.
EFFICIENCY IMPROVING FOR URLLC IN ADVANCED COMMUNICATION NETWORKS
Authors: КАШКАРОВ Д.В. , ПАРАМОНОВ А.И. , КУЧЕРЯВЫЙ А.Е. 
Published: March 2022

Предложен метод повышения эффективности использования ресурсов сети при предоставлении услуг с высокими требованиями uRLLC (ultra Reliable Low Latency Communications) к задержке путем организации многосвязных соединений. Метод основан на решении задачи оптимального выбора маршрутов из числа доступных с помощью динамического программирования. Показана возможность решения как задачи выбора заданного количества маршрутов, так и количества, обеспечивающего требуемую величину задержки. Близкое к оптимальному решение позволяет повысить эффективность использования ресурсов сети.
The paper proposes a method for increasing the efficiency of using network resources when providing services with high uRLLC (ultra Reliable Low Latency Communications) requirements for delay by organizing multi-link connections. The method is based on solving the problem of optimal selection of available routes using dynamic programming. The proposed method allows solving both the problem of selecting a given number of routes and minimizing the number of routes providing the required delay. A near-optimal solution improves the efficiency of network resource utilization.
INVESTIGATION OF THE INFLUENCE OF NETWORK CHARACTERISTICS ON THE FUNCTIONING OF A MULTIFUNCTIONAL ROBOTIC ARM
Authors: ГОРБАЧЕВА Л.С. , ФАМ В.Д. , МАТЮХИН А.Ю. , КУЧЕРЯВЫЙ А.Е. 
Published: March 2022

Приведены результаты экспериментальных исследований по предоставлению услуг телеприсутствия на модельной сети. Исследования проводились с помощью многофункционального робота-манипулятора Dobot Magician при предоставлении через модельную сеть услуг по перемещению грузов и рисованию окружностей. Проведено имитирование различных условий по затуханию, задержкам, расстояниям, на которых оказывались услуги, и битовым ошибкам. Сделаны выводы о единообразии требований к сетевым параметрам при оказании разных услуг одним и тем же многофункциональным роботом-манипулятором и о целесообразности уточнения рекомендаций МСЭ-Тв части величины задержки на 1 км.
The paper discusses the results of the experimental investigation on the provision of telepresence services on a model network. The investigation was carried out using the Dobot Magician multifunctional robotic arm, which provided services for moving loads and drawing circles through a model network. Various conditions for attenuation, delays, distances at which services were provided, and bit errors were simulated. Conclusions were drawn about the uniformity of requirements for network parameters when providing various services by the same multifunctional robotic arm and about the advisability of clarifying the ITU-T recommendations in terms of the delay per kilometer.
Mental Health in Conditions of COVID-19
Authors: Протько Н.Н. , Патеюк И.В. 
Published: March 2022

В статье описаны особенности психического здоровья людей в ситуации пандемии COVID-19: основные психотравмирующие факторы пандемии, типы психологических реакций на ситуацию, спектр психических расстройств, в том числе у пациентов с коронавирусной пневмонией. Приведены рекомендации по охране психического здоровья для населения в условиях пандемии COVID-19.
In the article, there are described the features of mental health of people in the situation of COVID-19 pandemic: the main psychotraumatic factors of the pandemic, the types of psychological reactions to the situation, the spectrum of mental disorders, including patients with coronavirus pneumonia. The recommendations on mental health protection in the context of COVID-19 pandemic are given.
A Clinical Case of Basal Cell Carcinoma Formation at the Site of Intralesional Injection of Triamcinolone Acetonide
Authors: Волькенштейн П. , Заславский Д.В. , Соболев А.В. , Скрек С.В. , Васильев Н.Ю. , Юновидова А.А. , Заславская О.Л. , Машука Д.М. , Зелянина М.И. , Рылева У.М. 
Published: March 2022

В статье представлен клинический случай развившейся базальноклеточной карциномы в месте введения триамцинолона. Особенностью клинического наблюдения является роль глюкокортикостероида как триггерного фактора в развитии злокачественной пролиферации кожи.Описан механизм действия триамцинолона ацетонида на ткани, а также основные группы лекарственных веществ, обладающие потенциальным риском иммуносупрессии и, как следствие, развития злокачественных опухолей кожи.Данный клинический случай интересен с точки зрения эпидемиологии для выявления группы риска развития базальноклеточной базалиомы у пациентов с длительным инъекционным применением кортикостероидов.
The article presents a clinical case of basal cell carcinoma developed at the site of triamcinolone injection. A feature of this case report is a role of glucocorticosteroids as a trigger factor in the development of malignant skin proliferation.The triamcinolone acetonide’s mechanism of action on tissues is described, as well as the main groups of drugs that have a potential risk of immunosuppression and as a consequence of the development of malignant skin tumors.This clinical case is interesting from the point of view of epidemiology for identifying the risk group for the development of basal cell basal cell carcinoma among patients with prolonged injection of corticosteroids.
Anemic Syndrome in Gastroenterological Diseases: Problems and Solutions
Authors: Рыбина О.В. , Губкин А.В. , Сахин В.Т. , Рукавицын О.А. 
Published: March 2022

Анемический синдром – наиболее частое внекишечное осложнение у пациентов с патологией желудочно-кишечного тракта (ЖКТ), которое может значимо ухудшить качество жизни. В зависимости от сочетания патогенетических механизмов выделяют железодефицитную, анемию хронических заболеваний, В12-дефицитную и фолиеводефицитную анемию. Другие варианты анемии встречаются реже. Необходимо проведение комплексного лабораторного обследования для установления ведущего фактора в развитии анемии и подбора адекватной терапии. Парентеральные формы препаратов железа и витаминов более предпочтительны для данной категории пациентов из-за более высокой биодоступности, низкого профиля безопасности и минимального негативного влияния на ЖКТ. Препараты эритропоэтина и ингибиторы провоспалительных цитокинов применяются в основном для коррекции анемии хронических заболеваний. Последние хорошо себя показали при терапии пациентов с анемическим синдромом на фоне тяжело протекающих воспалительных заболеваний кишечника. Проводятся различные клинические исследования, направленные на внедрение новых препаратов, корректирующих анемию. Однако к настоящему времени опыт их применения практически отсутствует.В этом обзоре мы постарались объединить и систематизировать накопленную информацию о проблеме анемического синдрома при патологиях желудочно-кишечного тракта.
Anemic syndrome is the most frequent extraintestinal complication in patients with gastrointestinal tract pathology, which can significantly impair the quality of life. Depending on the combination of pathogenetic mechanisms, the iron deficiency, anemia of chronic diseases, B12-deficiency, and folate deficiency anemia are distinguished. Other types of anemia are less common. It is necessary to conduct a comprehensive laboratory examination to reveal the leading factor in the development of anemia and select adequate therapy. Parenteral forms of iron and vitamin preparations are more preferable for this category of patients due to their higher bioavailability, low safety profile, and minimal negative effect on the gastrointestinal tract. Erythropoietin preparations and inhibitors of proinflammatory cytokines are used mainly for the correction of anemia of chronic diseases. The latter showed themselves well in the treatment of patients with anemic syndrome on the background of severe inflammatory bowel diseases. Various clinical trials are being conducted to introduce new drugs to correct anemia. However, today, there is practically no experience of their application.In this review, we tried to combine and systematize the accumulated information on the problem of anemic syndrome in the pathologies of the gastrointestinal tract.
Evaluation of the Safety of Direct-Acting Antiviral Agentsin Patients with Chronic HCV-Infection and with UGT1A1*28 Polymorphism
Authors: Лукашик С.П. , Карпов И.А. , Синявская М.В. , Даниленко Н.Г. , Анисько Л.А. , Давыденко О.Г. , Красько О.В. 
Published: March 2022

Цель. Оценить безопасность лекарственных средств прямого противовирусного действия (ЛС ППД) у пациентов с хронической инфекцией, вызванной вирусом гепатита С (ВГС-инфекцией), и полиморфизмом UGT1A1*28.Материалы и методы. Проведено клиническое открытое нерандомизированное ретроспективное обсервационное когортное исследование безопасности ЛС ППД у пациентов (n=143) с хроническим гепатитом С (ХГС) и циррозом печени (ВГС-ЦП) и полиморфизмом UGT1A1*28. Результаты. Билирубин повышался до 1-й степени у 52,9% при ХГС и у 47,1% при ВГС-ЦП, до 2-й или 3-й степени – у 55,6% при ХГС и 44,4% – при ВГС-ЦП (р=0,655). У пациентов с (ТА)6/(ТА)6 повышение показателя до 1-й степени наблюдалось у 23,5%, с (ТА)6/(ТА)7 – у 39,2%, с (ТА)7/ (ТА)7 – у 37,3%. Повышение билирубина до 2-й или 3-й степени чаще отмечалось при (ТА)6/ (ТА)7 и (ТА)7/(ТА)7 генотипах (50% и 44,4% соответственно) по сравнению с (ТА)6/(ТА)6 (5,6%) (p<0,001). Непосредственный вирусологический ответ достигнут в 88,6% при отсутствии повышения билирубина, в 91,8% – при повышении билирубина до 1-й степени и в 100% – до 2-й или 3-й степени (р=0,446). Отсутствовало повышение АЛТ у 98,6%, АСТ – у 99,3% и щелочной фосфатазы – у 80%. Ни у кого из пациентов лечение не было отменено.Выводы. Лечение пациентов с хронической ВГС-инфекцией ЛС ППД является безопасным.
Objective. To determine the safety of DAA in patients with chronic HCV-infection and UGT1A1*28 polymorphism.Materials and methods. A clinical open non-randomized retrospective observational cohort study was conducted to assess the safety of DAA in patients (n=143) with chronic hepatitis C (CHC) and liver cirrhosis (HCV-CP) and UGT1A1*28 polymorphism.Results. Bilirubin increased to 1 degree in 52.9% with CHC and in 47.1% with HCV-CL, to 2 or 3 degrees in 55.6% with CHC and 44.4% with HCV-CL (p=0.655). Bilirubin increased to 1 degree in patients with (TA)6/(TA)6 in 23.5%, with (TA)6/(TA)7 – in 39.2%, with (TA)7/(TA)7 – in 37.3%. Bilirubin increased to 2 or 3 degrees with (TA)6/(TA)7 in 50%, with (TA)7/(TA)7 genotypes in 44.4% and with (TA)6/(TA)6 – in 5.6% (p<0.001). IVR was achieved in 88.6% patients without an increase in bilirubin, in 91.8% with an increase to 1 degree and in 100% to 2 or 3 degrees (p=0.446). There was no increase in ALT in 98.6% cases, AST in 99.3% patients, and alkaline phosphatase in 80% ones. None of the patients had their treatment canceled.Conclusions. The treatment of patients with chronic HCV-infection with DAA is safe.
Evolution of accounting and information systems in cashless payments
Authors: Nazarova Iryna 
Published: March 2022

Introduction. Digitalization of the market economy creates conditions for minimizing cash payments. The abandonment from cash payments is justified by positive trends in: distancing e-commerce, the use of cashless payment systems and pandemic changes in socio-economic processes. Changes in the cash payments methods require the introduction of accounting and information systems for electronic recording of money operations, accounting and reporting of payment transactions, guarantees for the safety and control of cashless money.Purpose. The aim of the article is to research the evolution of accounting and information systems in the implementation of cashless payments in international and domestic markets for payment services, theoretical justification of the definition of «cashless payments» and develop proposals for their streamlining.Method. Methods of scientific research are: systematic approach to the study of economic processes, elements of the theory of scientific knowledge, dialectical method to determine the essence of cashless payments; historical - to research the evolution of cashless payments; analytical - to assess modern information systems for the organization and accounting of cashless payments.Results. The research of the cashless payments evolution shown the permanence changes in the methods of conducting money transactions. The accounting and information system of enterprises and corporations must timely respond on innovative transformations. The article improves and regulates the elements of the conceptual apparatus for cashless payments using bank payment cards, electronic money and other modern payment methods for the developing of their registration and reflection in accounting and reporting. Perspectives. Technological progress and the COVID-19 pandemic have become the driving force of society’s transition to expanding the cashless payment regime. Technologies for remote banking and non-banking payment systems are permanently improving. Accounting and information systems for providing complete and objective information to business and society should be in line with this progress.