bluuebunny/crossref_metadata_2025_split huggingface dataset:
Projections and Epidemiology of Total Ankle and Revision Total Ankle Arthroplasty in the United States to 2030
Authors: Shah Jason A. , Schwartz Andrew M. , Farley Kevin X. , Khamis Karim Mahmoud , Attia Ahmed K. , Labib Sameh (Sam) A. , Kadakia Rishin J. 
Published: November 2022

Category: Ankle Arthritis; Ankle Introduction/Purpose: Total ankle arthroplasty (TAA) utilization is increasing in the United States. As the incidence of this procedure grows, it is important for providers to understand the future projections for ankle arthroplasty and more importantly revision total ankle arthroplasty (rTAA). Methods: The national inpatient sample (USA) was queried from 2005 to 2017 for all TAA and rTAA. Poisson and linear regression analyses were performed to project annual incidence of TAA and rTAA to 2030, with subgroup analyses on septic rTAA. Results: There were 5315 TAAs performed in 2017, a 564% increase when compared to the TAAs performed in 2005. From 2017 to 2030, the incidence of TAAs is projected to increase from 110% to 796%. There were 1170 rTAAs performed in 2017, a 155% increase when compared to rTAAs performed in 2005. There was a 256% increase in the incidence of septic rTAAs from 2005 to 2017 with a projected increase between 22% and 120% by 2030. Conclusion: The incidence of both TAAs and rTAAs are projected to significantly increase over the next decade. Given the known risk factors of TAA and rTAA, these findings reinforce the need for thoughtful consideration when selecting patients for TAA.
Clinical Outcomes of Posterior Hindfoot Endoscopic Surgery using 1.9-mm Diameter Needle Arthroscopy for Posterior Ankle Impingement in Athletes
Authors: Shimozono Yoshiharu , Mizuno Yasuyuki , Funakoshi Noboru , Kobayashi Masahiko , Yamashita Fumiharu 
Published: November 2022

Category: Arthroscopy; Ankle; Hindfoot; Sports Introduction/Purpose: Posterior hindfoot endoscopy is a safe and effective treatment for posterior ankle impingement syndrome (PAIS). However, wound-healing problems following hindfoot endoscopy have been still reported. Recently, a novel 1.9- mm diameter needle-arthroscopic system has been introduced. Its small features can help reduce the risk of wound complications and can have the potential to make it earlier to return to play sports due to its minimally invasiveness. To our knowledge, no studies have been reported regarding PAIS treatment using a 1.9-mm diameter needle-arthroscopy. The purpose of this study was to report the clinical outcomes including return to sports following hindfoot endoscopic surgery using 1.9-mm diameter needle- arthroscopy for PAIS. Methods: Six patients who engaged in athletic activity (mean age 21.7 [range 16-34] years) and were treated by a hindfoot endoscopic surgery using a 1.9-mm diameter arthroscopic system (NanoScopeTM, Arthrex) for PAIS were included. In all patients, os trigonum was resected and flexor hallucis longus (FHL) tenosynovitis was debrided. American Orthopedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale score was evaluated and Visual analog scale (VAS) at 1 day and 2 weeks after surgery were recorded. Time to return to sports activity at preinjury level was also evaluated. Engaged sports included soccer (3 patients), ballet (2 patients), and lacrosse (1 patient). Results: The mean AOFAS score improved significantly from 77.7 to 100 after surgery (p<0.001). Mean VAS score at 1 day and 2 weeks were 1.5 (range 0-3) and 0.3 (range 0-1). respectively. All patients were able to return to full sports activities and the mean time to return to sports activities at preinjury level was 4.8 weeks (range 3-7 weeks). No complications were reported. Conclusion: Posterior hindfoot endoscopy using a 1.9-mm diameter needle-arthroscopy provided excellent clinical outcomes in the treatment of PAIS with relatively earlier return to play sports compared to conventional arthroscopy surgery, although this is not a comparative study. Minimum invasiveness with less postoperative pain using needle-arthroscopy may contribute to its early recovery. Further studies are required to support our results.
Relationship Between Macular Thickness and Visual Acuity in the Treatment of Diabetic Macular Edema With Anti-VEGF Therapy: Systematic Review
Authors: Wang Patrick , Hu Zoe , Hou Maggie , Norman Patrick A. , Chin Eric K. , Almeida David RP 
Published: November 2022

Purpose: To examine the relationship between central macular thickness (CMT) measured by optical coherence tomography (OCT) and visual acuity (VA) in patients with center-involving diabetic macular edema (DME) receiving antivascular endothelial growth factor (anti-VEGF) treatment. Methods: Peer-reviewed articles from 2016 to 2020 reporting intravitreal injections of bevacizumab, ranibizumab, or aflibercept that provided data on pretreatment (baseline) and final retinal thickness (CMT) and visual acuity (VA) were identified. The relationship between relative changes was assessed via a linear random-effects regression model controlling for treatment group. Results: No significant association between the logarithm of the minimum angle of resolution (logMAR) VA and CMT was found in 41 eligible studies evaluating 2667 eyes. The observed effect estimate was a 0.12 increase (95% CI, −0.124 to 2.47) in logMAR VA per 100 µm reduction in CMT after treatment change. There were no significant differences in logMAR VA between the anti-VEGF treatment groups. Conclusions: There was no statistically significant relationship between the change in logMAR VA and change in CMT as well as no significant effect of the type of anti-VEGF treatment on the change in logMAR VA. Although OCT analysis, including measurements of CMT, will continue to be an integral part of the management of DME, further exploration is needed on additional anatomic factors that might contribute to visual outcomes.
A phase 2 study of interleukin-22 and systemic corticosteroids as initial treatment for acute GVHD of the lower GI tract
Authors: Ponce Doris M. , Alousi Amin M. , Nakamura Ryotaro , Slingerland John , Calafiore Marco , Sandhu Karamjeet S. , Barker Juliet N. , Devlin Sean , Shia Jinru , Giralt Sergio , Perales Miguel-Angel , Moore Gillian , Fatmi Samira , Soto Cristina , Gomes Antonio , Giardina Paul , Marcello LeeAnn , Yan Xiaoqiang , Tang Tom , Dreyer Kevin , Chen Jianmin , Daley William L. , Peled Jonathan U. , van den Brink Marcel R. M. , Hanash Alan M. 
Published: November 2022

Abstract
Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality following allogeneic hematopoietic transplantation. In experimental models, interleukin-22 promotes epithelial regeneration and induces innate antimicrobial molecules. We conducted a multicenter single-arm phase 2 study evaluating the safety and efficacy of a novel recombinant human interleukin-22 dimer, F-652, used in combination with systemic corticosteroids for treatment of newly diagnosed lower gastrointestinal acute GVHD. The most common adverse events were cytopenias and electrolyte abnormalities, and there were no dose-limiting toxicities. Out of 27 patients, 19 (70%; 80% confidence interval, 56%-79%) achieved a day-28 treatment response, meeting the prespecified primary endpoint. Responders exhibited a distinct fecal microbiota composition characterized by expansion of commensal anaerobes, which correlated with increased overall microbial α-diversity, suggesting improvement of GVHD-associated dysbiosis. This work demonstrates a potential approach for combining immunosuppression with tissue-supportive strategies to enhance recovery of damaged mucosa and promote microbial health in patients with gastrointestinal GVHD. This trial was registered at www.clinicaltrials.gov as NCT02406651.
Determining venous thromboembolism risk in patients with adult-type diffuse glioma
Authors: Burdett Kirsten Bell , Unruh Dusten , Drumm Michael , Steffens Alicia , Lamano Jonathan , Judkins Jonathan , Schwartz Margaret , Javier Rodrigo , Amidei Christina , Lipp Eric S. , Peters Katherine B. , Lai Albert , Eldred Blaine S. C. , Heimberger Amy B. , McCortney Kathleen , Scholtens Denise M. , Horbinski Craig 
Published: November 2022

Abstract
Venous thromboembolism (VTE) is a life-threating condition that is common in patients with adult-type diffuse gliomas, yet thromboprophylaxis is controversial because of possible intracerebral hemorrhage. Effective VTE prediction models exist for other cancers, but not glioma. Our objective was to develop a VTE prediction tool to improve glioma patient care, incorporating clinical, blood-based, histologic, and molecular markers. We analyzed preoperative arterial blood, tumor tissue, and clinical-pathologic data (including next-generation sequencing data) from 258 patients with newly diagnosed World Health Organization (WHO) grade 2 to 4 adult-type diffuse gliomas. Forty-six (17.8%) experienced VTE. Tumor expression of tissue factor (TF) and podoplanin (PDPN) each positively correlated with VTE, although only circulating TF and D-dimers, not circulating PDPN, correlated with VTE risk. Gliomas with mutations in isocitrate dehydrogenase 1 (IDH1) or IDH2 (IDHmut) caused fewer VTEs; multivariable analysis suggested that this is due to IDHmut suppression of TF, not PDPN. In a predictive time-to-event model, the following predicted increased VTE risk in newly diagnosed patients with glioma: (1) history of VTE; (2) hypertension; (3) asthma; (4) white blood cell count; (5) WHO tumor grade; (6) patient age; and (7) body mass index. Conversely, IDHmut, hypothyroidism, and MGMT promoter methylation predicted reduced VTE risk. These 10 variables were used to create a web-based VTE prediction tool that was validated in 2 separate cohorts of patients with adult-type diffuse glioma from other institutions. This study extends our understanding of the VTE landscape in these tumors and provides evidence-based guidance for clinicians to mitigate VTE risk in patients with glioma.
A randomized, placebo-controlled phase 3 trial of the PI3Kδ inhibitor leniolisib for activated PI3Kδ syndrome
Authors: Rao V. Koneti , Webster Sharon , Šedivá Anna , Plebani Alessandro , Schuetz Catharina , Shcherbina Anna , Conlon Niall , Coulter Tanya , Dalm Virgil A. , Trizzino Antonino , Zharankova Yulia , Kulm Elaine , Körholz Julia , Lougaris Vassilios , Rodina Yulia , Radford Kath , Bradt Jason , Kucher Klaus , Relan Anurag , Holland Steven M. , Lenardo Michael J. , Uzel Gulbu 
Published: November 2022

AbstractActivated phosphoinositide 3-kinase delta (PI3Kδ) syndrome (APDS) is an inborn error of immunity with clinical manifestations including infections, lymphoproliferation, autoimmunity, enteropathy, bronchiectasis, increased risk of lymphoma, and early mortality. Hyperactive PI3Kδ signaling causes APDS and is selectively targeted with leniolisib, an oral, small molecule inhibitor of PI3Kδ. Here, 31 patients with APDS aged ≥12 years were enrolled in a global, phase 3, triple-blinded trial and randomized 2:1 to receive 70 mg leniolisib or placebo twice daily for 12 weeks. Coprimary outcomes were differences from baseline in the index lymph node size and the percentage of naïve B cells in peripheral blood, assessed as proxies for immune dysregulation and deficiency. Both primary outcomes were met: the difference in the adjusted mean change (95% confidence interval [CI]) between leniolisib and placebo for lymph node size was −0.25 (−0.38, −0.12; P = .0006; N = 26) and for percentage of naïve B cells, was 37.30 (24.06, 50.54; P = .0002; N = 13). Leniolisib reduced spleen volume compared with placebo (adjusted mean difference in 3-dimensional volume [cm3], −186; 95% CI, −297 to −76.2; P = .0020) and improved key immune cell subsets. Fewer patients receiving leniolisib reported study treatment-related adverse events (AEs; mostly grades 1-2) than those receiving placebo (23.8% vs 30.0%). Overall, leniolisib was well tolerated and significant improvement over placebo was notable in the coprimary endpoints, reducing lymphadenopathy and increasing the percentage of naïve B cells, reflecting a favorable impact on the immune dysregulation and deficiency seen in patients with APDS. This trial was registered at www.clinicaltrials.gov as #NCT02435173.
A Novel 6-DOF Force-Sensed Human-Robot Interface for an Intuitive Teleoperation
Authors: Li Zihao , Xie Fugui , Ye Yanlei , Li Peng , Liu Xinjun 
Published: November 2022

AbstractThe teleoperation of a 6 degrees-of-freedom (DOF) manipulator is one of the basic methods to extend people’s capabilities in the wide variety of applications. The master interface based on the force/torque (FT) sensor could provide the full-dimension intuitive teleoperation of a 6-DOF robot since it has the ability to trigger 6-DOF command input. However, due to the force coupling, noise disturbance and unlimited input signals of the FT sensor, this force-sensed interface could not be widely used in practice. In this paper, we present an intuitive teleoperation method based on the FT sensor to overcome these challenges. In this method, the input signals from the force-sensed joystick were filtered and then processed to the force commands by force limit algorithm, with the merits of anti-interference, output limitation, and online velocity adjustment. Furthermore, based on the admittance control and position controller, the manipulator could be teleoperated by the force commands. Three experiments were conducted on our self-designed robotic system. The result of the first experiment shows that the interfered force from the force coupling could be effectively suppressed with the limitation of the input force through force limit algorithm. Then, a parameter was introduced in the other two experiments to adjust the velocity online practically with force limit algorithm. The proposed method could give a practical solution to the intuitive teleoperation based on the FT sensor.
Enhanced pain facilitation rather than impaired pain inhibition in burning mouth syndrome female patients
Authors: Gremeau-Richard Christelle , Pionchon Paul , Mulliez Aurélien , Dualé Christian , Dallel Radhouane 
Published: November 2022

Abstract
Background
Deficient endogenous pain modulation has been implicated in the development and exacerbation of chronic orofacial pain. To date, relatively little is known regarding the function of the endogenous pain modulation in patients with burning mouth syndrome (BMS). This case–control study investigated endogenous pain modulation in women with BMS.

Methods
Conditioned pain modulation (CPM) was assessed upon temporal summation (TSP) of thermal pain. Forty female subjects, 20 BMS patients and 20 age-matched control subjects, were included in a 2 session-protocol. Mechanical and thermal pain thresholds were measured on the forearm and hand. TSP was obtained using repetitive laser-evoked thermal stimuli applied on the non-dominant hand, at an intensity yielding to moderate pain. During TSP, CPM was produced by immersing the contralateral foot in a water bath at painful cold (8 °C) temperature. In control conditions, the foot was immersed in a water bath at not painful (30 °C) temperature.

Results
BMS was not associated with any impairment in thermal as well as mechanical extracephalic pain thresholds. TSP and CPM efficacy were similar in BMS patients and control subjects. However, BMS patients exhibited enhanced extracephalic heat hyperalgesia.

Conclusion
This study reveals that there is no impairment of endogenous pain inhibition mechanisms in BMS patients, but rather an increase in pain facilitation.
Post-traumatic endophthalmitis prophylaxis: a systematic review and meta-analysis
Authors: Van Swol Joshua M. , Myers Walter K. , Beall Jonathan A. , Atteya Miriam M. , Blice Jeffrey P. 
Published: November 2022

Abstract
Purpose
The goal of this study is to determine if certain aspects of endophthalmitis prophylaxis strategies are superior to others.

Design
This investigation is a systematic review and meta-analysis.

Methods
All studies specifying a type of prophylaxis strategy and resulting rates of endophthalmitis were included. Time course, method of administration, and antibiotic regimen, and confounding factors were collected and included for meta-regression.

Results
Time courses greater than 24 h did not significantly improve outcomes. Likewise, intraocular and/or intravenous antibiotic administration methods did not significantly outperform oral administration. No antibiotic regimens performed differently from vancomycin/ ≥ 3rd generation cephalosporin except for ciprofloxacin monotherapy which yielded significantly worse outcomes.

Conclusions
Future antibiotic strategies should strongly consider the risks of antibiotic treatment > 24 h and administration methods other than the oral antibiotic forms. In addition, providers should be wary of using ciprofloxacin monotherapy for endophthalmitis prophylaxis when treating open globe injuries.
Genome-wide association studies revealed complex genetic architecture and breeding perspective of maize ear traits
Authors: Khatun Mita , Monir Md Mamun , Lou Xiangyang , Zhu Jun , Xu Haiming 
Published: November 2022

Abstract
Background
Maize (Zea Mays) is one of the world’s most important crops. Hybrid maize lines resulted a major improvement in corn production in the previous and current centuries. Understanding the genetic mechanisms of the corn production associated traits greatly facilitate the development of superior hybrid varieties.

Result
In this study, four ear traits associated with corn production of Nested Association Mapping (NAM) population were analyzed using a full genetic model, and further, optimal genotype combinations and total genetic effects of current best lines, superior lines, and superior hybrids were predicted for each of the traits at four different locations. The analysis identified 21–34 highly significant SNPs (−log10P > 5), with an estimated total heritability of 37.31–62.34%, while large contributions to variations was due to dominance, dominance-related epistasis, and environmental interaction effects ($${h}_{D+}^2\hat{=}$$

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14.06% ~ 49.28%), indicating these factors contributed significantly to phenotypic variations of the ear traits. Environment-specific genetic effects were also discovered to be crucial for maize ear traits. There were four SNPs found for three ear traits: two for ear length and weight, and two for ear row number and length. Using the Enumeration method and the stepwise tuning technique, optimum multi-locus genotype combinations for superior lines were identified based on the information obtained from GWAS.

Conclusions
Predictions of genetic breeding values showed that different genotype combinations in different geographical regions may be better, and hybrid-line variety breeding with homozygote and heterozygote genotype combinations may have a greater potential to improve ear traits.
Modulation of physiological and biochemical traits of two genotypes of Rosa damascena Mill. by SiO2-NPs under In vitro drought stress
Authors: Hajizadeh Hanifeh Seyed , Azizi Sahar , Rasouli Farzad , Okatan Volkan 
Published: November 2022

AbstractBackgroundDrought is a major abiotic stress that restricts plant growth and efficiency although some nutrients such as silicon improve drought tolerance by regulating the biosynthesis and accumulating some osmolytes. In this regard, a completely randomized factorial design was performed with three factors including two genotypes (‘Maragheh’ and ‘Kashan’), three concentrations of silicon dioxide nanoparticles (SiO2-NPs) (0, 50, and 100 mg L− 1), and five concentrations of PEG (0, 25, 50, 75, and 100 g L− 1) with three replications.ResultsThe findings showed that drought stress decreased protein content and it was improved by SiO2-NPs, so the genotype of ‘Maragheh’ treated with 100 mg L− 1SiO2-NPs had the highest protein content. Under severe drought stress, had a higher membrane stability index (MSI) than ‘Kashan’, and the ‘Maragheh’ explants subjected to 100 mg L− 1SiO2-NPs exhibited the uppermost MSI. The explants supplemented with 100 mg L− 1SiO2-NPs sustained their photosynthetic parameters more in comparison with other treatments under drought stress conditions and as well as 100 mg L− 1SiO2-NPs showed higher content of protein and proline of ‘Maragheh’ than ‘Kashan’. Drought stress reducedFm,Fv/Fm, andFv, while SiO2-NPs treatment enhanced these parameters. SiO2-NPs also improved water deficit tolerance by enhancing the activity of antioxidant enzymes such as catalase (CAT), peroxidase (POD), guaiacol peroxidase (GPX), and superoxide dismutase (SOD) and reducing lipid peroxidation and H2O2concentration.ConclusionsAccording to the findings, the genotype ‘Maragheh’ was more tolerance to drought stress than ‘Kashan’ by improving water balance, antioxidant enzyme activities, and membrane stability as it was obtained from the unpublished previous evaluation in in vivo conditions and we concluded based on these results, in vitro culture can be used for drought screening in Damask rose plants. The results of the current study revealed that the induced drought stress by polyethylene glycol (PEG) in two Damask rose genotypes was ameliorated with SiO2-NPs and the tolerance genotypes were better than the sensitive ones in response to SiO2-NPs treatment.
Von Hippel–Lindau syndrome with a rare complication of dilated cardiomyopathy: a case report
Authors: Yu Ming , Du Beibei , Yao Shuai , Ma Jianghong , Yang Ping 
Published: November 2022

Abstract
Background
Von Hippel–Lindau (VHL) syndrome is an autosomal dominant hereditary disease affecting multiple organs, with pheochromocytoma in 26% of cases. However, VHL syndrome with congestive heart failure and dilated cardiomyopathy as the primary clinical manifestations has been rarely reported.

Case presentation
A 35-year-old male patient was admitted to the hospital with dyspnea. The patient had a history of cerebellar hemangioblastoma that had been resected, and a one-year history of hypertension. Echocardiography and cardiac magnetic resonance imaging demonstrated a dilated left ventricle, decreased systolic function, and nonischemic myocardial changes. Contrast-enhanced abdominal computed tomography showed pheochromocytoma, neoplastic lesions, and multiple cysts in the kidneys and pancreas. Genetic analysis revealed a missense mutation of the VHL gene, c.269 A > T (p.Asn90Ile), which was identified as the cause of the disease. Dilated cardiomyopathy and VHL syndrome type 2 were diagnosed. The patient was administered a diuretic, α-blocker, β-blocker, and an angiotensin receptor neprilysin inhibitor (ARNI), but refused pheochromocytoma resection. At the six-month follow-up, the patient was asymptomatic with improved cardiac function.

Conclusion
Cardiac involvement is an atypical manifestation in VHL syndrome. Early diagnosis with genetic screening is essential for avoiding life-threatening complications associated with VHL. The management of this rare manifestation of VHL syndrome requires further investigation.