bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resolvin D1 modulates periodontal ligament fibroblast function
Authors: Zarrough Ahmed E. , Hasturk Hatice , Stephens Danielle N. , Van Dyke Thomas E. , Kantarci Alpdogan 
Published: November 2022

AbstractBackgroundThe resolution of inflammation is an active process mediated by specialized lipid mediators called lipoxins and resolvins. Periodontal ligament fibroblasts (PDLFs) play a significant role in periodontal regeneration. The purpose of the current study was to determine the impact of resolvin D1 (RvD1) on human PDLF cell wound healing and proliferation, receptor expression (G‐protein‐coupled receptor 32 [GPR32] and formyl peptide receptor 2 [ALX/FPR2]), and cytokine expression and release.MethodsPDLFs were stimulated with interleukin‐1β (IL‐1β) (500 pg/ml) with and without RvD1 (100 nM). RvD1 receptor expression was determined by quantitative real‐time polymerase chain reaction (qPCR), immunofluorescence microscopy, and fluorescence‐activated cell sorting. Wound closure was measured by a scratch assay, and proliferation was determined by bromodeoxyuridine incorporation. Interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), monocyte chemoattractant protein‐1, cyclooxygenase‐2, matrix metalloproteinases‐1, ‐2, and ‐3 (MMP‐1, ‐2, and ‐3), tissue inhibitors of metalloproteinases‐1 and ‐2 (TIMP‐1 and ‐2), prostaglandin E2, and osteoprotegerin (OPG) gene expression and production were measured using qPCR and Western blotting, multiplex immunoassay, and enzyme‐linked immunosorbent assay.ResultsPDLF expressed GPR32 and ALX/FPR2. RvD1 reversed IL‐1β‐induced inhibition of wound healing and proliferation of PDLF. IL‐1β also induced the production of proinflammatory cytokines and MMPs. This effect was reversed by RvD1. RvD1 reversed IL‐1β‒induced inhibition of TIMP‐1, TIMP‐2, and OPG.ConclusionThe data suggested that RvD1 has a pro‐wound healing, proliferative, and anti‐inflammatory impact on the PDLF that favors periodontal regeneration.
Effects of the Gully Land Consolidation Project on soil erosion and sediment yield on the Loess Plateau, China
Authors: Wu Ge , Fu Suhua , Zhou Guiyun , Yin Bing 
Published: November 2022

AbstractLand consolidation can increase the area of arable land and improve the ecology and environment and is widely used worldwide. The Gully Land Consolidation (GLC), as a special type of land consolidation, significantly impacts soil erosion. The purpose of this study was to investigate the effect of the GLC on soil erosion and sediment yield under different rainfall events and hydrological years in the Xingshuyaozi watershed on the Chinese Loess Plateau, where the GLC area accounted for 10.36% of the watershed. A computer model integrated with the Chinese soil loss equation (CSLE) and the continuity equation of sediment was used. Sediment connectivity before and after the GLC was compared to illustrate the effect of the GLC on sediment yield. The results showed that the reduction in soil loss increased with increasing rainfall amount, and the reduction rate of soil erosion was over 50%. The GLC had the greatest effect on soil erosion in wet years. The GLC effectively decreased sediment at the outlet of the watershed, with over 99% of the sediment being trapped. The reduction efficiency of soil erosion and sediment yield decreased in order of wet year, normal year and dry year. The decreased soil erosion and sediment yield resulted from the significantly lowered slope gradients and sediment connectivity after the GLC. These results indicate that the GLC is an effective soil and water conservation measure. These results can provide technical support for the application of the GLC and policymaking.
Editorial H‐score as a metric of inner authenticity for national scientific journals—Pilot study for the field of pedagogy
Authors: Novotný Petr , Sezemská Karolína Kotvaltová , Schubertová Romana , Janštová Vanda 
Published: November 2022

AbstractThere is evidence that national scientific journals are important for local communities despite their limited audience due to national languages and topics, like in pedagogy. However, it is not easy to assess the level of scientific rigour of local journals, as most do not have available scientometric data and are often published in minority languages. We hypothesize that a possible manifestation of a latent trait of inner authenticity of the scientific journal (meaning the journal is accepted by a community interested in developing the field which conducts internationally accepted research) could be H‐index of the editorial board members. To test this approach, we evaluated H‐index and gender of editorial board members (n = 490) from 17 Czech and Slovak national science‐oriented scientific pedagogical journals which were not indexed or indexed in Erih+ or Scopus, and compared this with the five lowest‐rated journals from the same field indexed in the Web of Science (WoS) database. The H‐index of editorial board members was somewhat higher in indexed journals with those from WoS showing higher scores, and the number of board members with no discernable H‐index was far greater in non‐indexed journals. Editorial boards of journals indexed in WoS were mostly male, compared to a dominance of women on boards of non‐indexed journals. Acknowledging the limited sample, it appears that the H‐index of editorial board members may be a way to value national scientific journals.
Plasma neuropeptide levels in patients with schizophrenia, bipolar disorder, or major depressive disorder and healthy controls: A multiplex immunoassay study
Authors: Hidese Shinsuke , Yoshida Fuyuko , Ishida Ikki , Matsuo Junko , Hattori Kotaro , Kunugi Hiroshi 
Published: November 2022

AbstractAimWe aimed to compare neuropeptide levels between patients with major psychiatric disorders and healthy controls and examine their association with symptoms and cognitive function.MethodsThe participants were 149 patients with schizophrenia, 115 patients with bipolar disorder (BD), 186 unremitted patients with major depressive disorder (MDD), and 350 healthy controls. Psychiatric (schizophrenic, manic, and depressive) symptoms, sleep state, and cognitive (premorbid intelligence quotient, general cognitive, and memory) functions were evaluated. A multiplex immunoassay kit was used to measure cerebrospinal fluid (CSF) and plasma α‐melanocyte‐stimulating hormone (MSH), β‐endorphin, neurotensin, oxytocin, and substance P levels.ResultsThe verification assay revealed that CSF α‐MSH, β‐endorphin, neurotensin, oxytocin, and substance P levels were too low to be reliably measured, while plasma α‐MSH, β‐endorphin, neurotensin, oxytocin, and substance P levels could be successfully measured. Plasma α‐MSH, β‐endorphin, neurotensin, oxytocin, and substance P levels were not significantly different between patients with schizophrenia, BD, or MDD and healthy controls. Plasma α‐MSH, β‐endorphin, neurotensin, oxytocin, and substance P levels were not significantly correlated with psychiatric symptom scores in patients with schizophrenia, BD, or MDD and cognitive function scores in patients or healthy controls.ConclusionOur data suggest that plasma neuropeptide levels do not elucidate the involvement of neuropeptides in the pathology of schizophrenia, BD, or MDD.
Pt–Au alloy nanoparticles synthesized by glow discharge plasma for enhanced methanol oxidation reaction performance
Authors: Zhang Anyu , Zhang Jianan , Zheng Jingxuan , Wang Zhao 
Published: November 2022

AbstractPt–Au alloy is greatly important to direct methanol fuel cells as electrocatalysts given its stability and anti‐COads poisoning ability. Herein, Pt and Au ions are successfully prepared into Pt–Au alloy nanoparticles by glow discharge plasma without a reducing agent at room temperature. The high electrons from plasma accelerate to form intermetallic compounds. The low operating temperature of plasma inhibits the agglomeration of particles. Compared with the samples by traditional hydrogen thermal reduction, the catalytic activity and stability of samples in the methanol oxidation reaction (MOR) by plasma are improved due to the stronger metal–metal interaction and smaller size of nanoparticles. The optimal proportion of Pt15Au5/C showed the highest mass activity and specific activity of 1.52 and 6.59 times those of commercial JM Pt/C in electrocatalytic methanol oxidation.
Oscillatory mechanics in very preterm infants on continuous positive airway pressure support: Reference values
Authors: Zannin Emanuela , Rigotti Camilla , Neumann Roland P. , Dellacà Raffaele L. , Schulzke Sven , Ventura Maria L. 
Published: November 2022

AbstractObjectiveTo create reference values for respiratory system resistance (Rrs) and reactance (Xrs) measured by the forced oscillation technique (FOT) in nonintubated very preterm infants.DesignRetrospective analysis of data collected as part of prospective observational studies in two centers.SettingTertiary neonatal intensive care units.PatientsNon‐intubated infants below 32 weeks' gestation age who did not develop bronchopulmonary dysplasia.InterventionsWe applied FOT using a mechanical ventilator (Fabian HFOi; Vyaire) that superimposed small‐amplitude oscillations (10 Hz) on a continuous positive airway pressure of 3 and 5 cmH2O. Measurements were performed during regular tidal breathing using a face mask.Main outcome measuresWe analyzed 198 measurements performed between 7 postnatal days and 40 weeks postmenstrual age (PMA) in 85 infants, with a median (Q1, Q3) gestational age of 30.43 (29.14, 31.18) weeks. Logarithmic transformations were applied to Rrs and Xrs, and the relationship between transformed impedance values and demographic factors was examined by backwards stepwise linear regression.ResultsIn univariable analysis, transformed Xrs was significantly associated with PMA, postnatal age, weight, and length, while Rrs was not. The best multivariable regression model estimating transformed Xrs (cmH2O*s/L) at continuous positive airway pressure (CPAP) = 5 cmH2O was: Ln(50 − Xrs) = 4.536 − 0.009 x PMA − 0.014 x weight z‐score. SEE = 0.053, R2 = 0.36. The mean (SD) Rrs at CPAP = 5 cmH2O was 33.63 (5.28) cmH2O*s/L.ConclusionWe have established reference values for Rrs and Xrs at 10 Hz in nonintubated preterm neonates on continuous positive airway pressure support.
Refinement of newborn screening for cystic fibrosis with next generation sequencing
Authors: Rock Michael J. , Baker Mei , Antos Nicholas , Farrell Philip M. 
Published: November 2022

AbstractBackgroundNewborn screening for cystic fibrosis (CF) has been underway universally in the United States for more than a decade, as well in most European countries, and algorithms have been evolving throughout this period with quality improvement projects as immunoreactive trypsinogen (IRT) determinations alone have been transformed to a 2‐tier strategy with DNA analyses.ObjectiveTo apply next generation sequencing (NGS) as a screening method to expand the DNA tier and identify substantially more variants in the CF transmembrane conductance regulator (CFTR) gene to enhance sensitivity and equity while minimizing incidental findings.DesignSequential evaluation and improvement plan in three phases using algorithm modifications coupled to statewide follow up and analysis of screening outcomes.ResultsAfter demonstrating feasibility in the first phase, we studied an IRT/NGS algorithm that included CFTR Variants with Varying Clinical Consequences (VVCCs). This revealed a high identification of CF patients with 2‐variants detected through screening, but for every CF case there were 1.4 with CF metabolic syndrome/CF screen positive, inconclusive diagnosis (CRMS/CFSPID). This led us to a third phase of improvement in which the VVCCs were eliminated except for R117H, resulting in 94% 2‐variant detection of patients and 0.44:1 ratio of CRMS/CFSPID to CF.ConclusionNGS can be used with IRT as an effective method of identifying infants at risk for CF without an appreciable increase in detection of carriers. Its potential added value includes facilitating equity, enhancing sensitivity and detecting more CF patients with 2‐variants during the screening process.
Immunophenotyping identifies distinct cellular signatures for systemic lupus erythematosus and lupus nephritis
Authors: Aw Yi Tong V. , Whiley Phillip J. , Lorenzo Ayla May , Lea‐Henry Tom , Shanmuganandam Somasundhari , Stanley Maurice , Babu Sonia N. , Athanasopoulos Vicki , Cappello Jean , Ellyard Julia I. , Cook Matthew , Vinuesa Carola , Walters Giles , Fulcher David A. , Jiang Simon H. 
Published: November 2022

AbstractBackgroundSystemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by development of autoantibodies and multiorgan involvement. Kidney involvement, termed lupus nephritis, has major impact on life expectancy. It is increasingly recognized that SLE is likely a common clinical manifestation of pathophysiologically diverse processes, and lupus nephritis has similarly been associated with several distinct immunological processes. We compared the immune cell phenotypes of individuals with SLE in the presence or absence of nephritis.MethodsCryopreserved peripheral blood mononuclear cells from SLE patients with and without kidney involvement underwent flow cytometric analysis to identify major populations in T cells, B cells and myeloid lineages.ResultsWe compared the frequencies of lymphocyte populations in 69 SLE patients without nephritis, 20 SLE patients with nephritis, and 92 healthy blood donors. Patients with SLE and lupus nephritis (LN) had reduced marginal zone B cells (P < 0.0001 in SLE; P = 0.001 in LN), memory B cells (P = 0.002 in SLE; P = 0.001 in LN) and circulating T follicular helper (Tfh) memory cells (P < 0.0001 in SLE and LN) compared to healthy donors. Patients with lupus nephritis had increase Th2 (P < 0.0001) and T regulatory cells (P < 0.0001) compared to both SLE patients without nephritis and healthy donors.ConclusionSLE patients with and without lupus nephritis have distinct immunologic differences that may reflect the unique pathophysiological processes contributing to disease manifestations.
Synchronous robotic repair of anterior diaphragmatic (Morgagni) hernia & low anterior resection for rectal cancer
Authors: Lambert Joel , Shugaba Abdul , Sheikh Adnan , Gill Michael 
Published: November 2022

AbstractBackgroundWe present the case report of synchronous trans‐fascial repair of a large congenital Morgagni hernia (MH) and low anterior resection using a fully robotic approach.MethodsA 61‐year old female presented with fresh red blood in her stool. She had a previous history of abdominal hysterectomy and a performance status of 0. Imaging revealed a low rectal cancer and incidental large MH.ResultsUsing the Da Vinci X platform the procedure was successfully performed; total operating time of 450 min, <200 ml blood loss and 5 days hospital stay. Post‐operative scan at 6 months, 1 and 2 years showed no evidence of hernia or cancer recurrence.ConclusionWe have demonstrated that complex multi‐visceral procedures can be safely performed on fully robotic platforms, even in previously disturbed surgical fields. The robotic approach may provide the opportunity for seamless multi‐speciality operating simultaneously in multiple body cavities.
Print Learning: A Theoretical Framework for the Role of Children's Learning about the Orthography in the Development of Reading Skill
Authors: Conrad Nicole J. , Deacon S. Hélène 
Published: November 2022

ABSTRACTAll dominant models of reading development ascribe a central role to learning about the orthography in reading acquisition, particularly as children transition to fluent word reading (e.g., Ehri, 2014; Share, 1995). And yet, we know far less about the contributions to word reading development of children's learning about the orthographic form of language than about its phonological dimensions. Through a focused review, we put forward a new conceptualization about the role of learning about the orthography in reading development. This new theoretical framework defines a broader conceptual and developmental scope of print learning, and it predicts bidirectional relations between print learning and word reading development. This theoretical framework both encompasses and expands traditional views on the role of learning about the orthography in reading development. We hope that this framework will both unify and guide theoretical conceptualizing and empirical research.
Success factors of global goal‐setting for sustainable development: Learning from the Millennium Development Goals
Authors: Hickmann Thomas , Biermann Frank , Spinazzola Matteo , Ballard Charlotte , Bogers Maya , Forestier Oana , Kalfagianni Agni , Kim Rakhyun E. , Montesano Francesco S. , Peek Tom , Sénit Carole‐Anne , van Driel Melanie , Vijge Marjanneke J. , Yunita Abbie 
Published: November 2022

AbstractThe Millennium Development Goals (MDGs) were an important precursor to the Sustainable Development Goals (SDGs). Hence, identifying the conditions that made the MDGs successful enhances our understanding of global goal‐setting and informs the global endeavour to achieve the SDGs. Drawing on a comprehensive review of 316 articles published between 2009 and 2018, we identify six factors that have enabled or hindered MDG implementation. Our analysis stresses the importance of path dependencies and shows that the MDGs catalysed changes only for those countries with sufficient resource availability, administrative capacity and economic development, as well as adequate support from external donors. National ownership and NGO pressure bolstered efforts to implement the MDGs. These findings suggest that globally agreed goals do not easily trickle down from the global to the national level. Thus, this article adopts a forward‐looking perspective and draws key lessons for the current implementation of the SDGs in developing countries.
Opportunities for circular bionutrient economy in Kenya: Sanitation and waste stream characterization
Authors: Midega Charles A. O. 
Published: November 2022

AbstractThe majority of people in low‐ and middle‐income countries, such as Kenya, lack effective sanitation and waste management systems. Circular bionutrient economy (CBE) is emerging as a framework to safely reuse organic wastes in agriculture. This study aimed to characterize waste and sanitation systems in Kisumu City, Kenya, with a view to exploring opportunities for CBE in the Lake Victoria basin. Sanitation was characterized through a case study approach in a populous informal settlement, and waste was quantified in two markets in the city. The main toilet facility was pit latrine, although there were also some urine‐diverting dry toilets (UDDTs). One toilet served about 36 people. Over a 1‐mo period, the UDDTs yielded approximately 64,400 L of urine, whereas about 67,500 L of fecal sludge was emptied from the pit latrines, out of which only about 33,000 L (48.9%) was properly disposed of. About 3 t of waste was generated daily from the markets, 95% of which was organic, and was disposed of at an open dumpsite. Organic waste, including human excreta, contains large amounts of organic matter and plant nutrients, and can be processed for agricultural nutrient cycles. Additionally, black soldierly larvae can effectively convert organic waste into nutrient‐rich fertilizer and high protein biomass for animal feeds. These results suggest an opportunity for a CBE system in the region for sustainable organic waste management and urban sanitation, and with opportunity to improve livelihoods and equity.
5G‐based remote magnetically controlled capsule endoscopy for examination of the stomach and small bowel
Authors: Zhang Ting , Chen Yi‐Zhi , Jiang Xi , He Chen , Pan Jun , Zhou Wei , Hu Jian‐Ping , Liao Zhuan , Li Zhao‐Shen 
Published: November 2022

AbstractBackground and aimsRemote endoscopy can improve diagnostic efficiency of gastrointestinal (GI) diseases for patients in remote areas. A novel remote magnetically controlled capsule endoscopy (MCE) system based on a 5G network was developed for real‐time remote GI examinations. We aimed to evaluate the feasibility and safety of the 5G‐based remote MCE for examination of the stomach and small bowel.MethodsThis was a prospective, nonrandomized, comparative study. Consecutive participants enrolled in the First People's Hospital of Yinchuan underwent remote MCE examinations performed by an endoscopist located in Changhai Hospital. Consecutive participants enrolled in Changhai Hospital underwent conventional MCE examinations performed by the same endoscopist. The main outcomes included the complete visualization rate of the stomach and small bowel, safety assessment and network latency time of remote MCE examinations.ResultsFrom March 2021 to June 2021, 20 participants in each group were enrolled. The complete visualization rate of the stomach and small bowel was 100% in both groups (p > 0.999) without any adverse event. The median network latency time of remote MCE group was 19.948 ms. Gastric examination time (8.96 vs. 8.92 min, p = 0.234), maneuverability (15.00 vs. 15.00, p = 0.317), image quality (1.00 vs. 1.00, p > 0.999) and diagnostic yields in the stomach and small bowel (55% vs. 30%, 5% vs. 0%, both p > 0.05) were comparable between remote and conventional MCE groups. All participants in remote MCE group considered remote MCE acceptable and necessary.Conclusions5G‐based remote MCE was a feasible and safe method for viewing the stomach and small bowel.
Immunotoxicity of nanomaterials in health and disease: Current challenges and emerging approaches for identifying immune modifiers in susceptible populations
Authors: Hofer Sabine , Hofstätter Norbert , Punz Benjamin , Hasenkopf Ingrid , Johnson Litty , Himly Martin 
Published: November 2022

AbstractNanosafety assessment has experienced an intense era of research during the past decades driven by a vivid interest of regulators, industry, and society. Toxicological assays based on in vitro cellular models have undergone an evolution from experimentation using nanoparticulate systems on singular epithelial cell models to employing advanced complex models more realistically mimicking the respective body barriers for analyzing their capacity to alter the immune state of exposed individuals. During this phase, a number of lessons were learned. We have thus arrived at a state where the next chapters have to be opened, pursuing the following objectives: (1) to elucidate underlying mechanisms, (2) to address effects on vulnerable groups, (3) to test material mixtures, and (4) to use realistic doses on (5) sophisticated models. Moreover, data reproducibility has become a significant demand. In this context, we studied the emerging concept of adverse outcome pathways (AOPs) from the perspective of immune activation and modulation resulting in pro‐inflammatory versus tolerogenic responses. When considering the interaction of nanomaterials with biological systems, protein corona formation represents the relevant molecular initiating event (e.g., by potential alterations of nanomaterial‐adsorbed proteins). Using this as an example, we illustrate how integrated experimental–computational workflows combining in vitro assays with in silico models aid in data enrichment and upon comprehensive ontology‐annotated (meta)data upload to online repositories assure FAIRness (Findability, Accessibility, Interoperability, Reusability). Such digital twinning may, in future, assist in early‐stage decision‐making during therapeutic development, and hence, promote safe‐by‐design innovation in nanomedicine. Moreover, it may, in combination with in silico‐based exposure‐relevant dose‐finding, serve for risk monitoring in particularly loaded areas, for example, workplaces, taking into account pre‐existing health conditions.This article is categorized under:
Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials