bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: Chronological symptom profile after cessation of overdose zolpidem in a patient with comorbid bipolar disorder—from anxiety, craving, paresthesia and influenza-like symptoms to seizures and hallucinations
Authors: Mao Zi-xin , Yang Xia , Wang Hui-yao , Guo Wan-jun 
Published: August 2022

IntroductionInsomnia is a major public health problem that determines the quality of life. Among the many causes of insomnia, psychological factors have an important influence on the process, duration of insomnia, help-seeking behavior, and treatment choice. Regarding medical treatment, zolpidem is always chosen to treat acute and transient insomnia due to its few side effects. Although some randomized controlled trials have verified its safety, zolpidem abuse and withdrawal reactions have been reported in recent years.Case reportA 25-year-old unmarried man with a college degree who worked as a graphic designer was referred and admitted to the inpatient ward for a chief complaint of “alternative episodes of lowering and elevation of mood for 10 years, overdosage use of zolpidem for two years.” He underwent a time-dependent withdrawal reaction after admission. It was characterized by rebound insomnia, anxiety, craving, skin paresthesia, influenza-like symptoms, tonic-clonic-type seizures, and hallucinations. At the 1-year follow-up, he did not exhibit any remaining withdrawal symptoms.DiscussionThe acute cessation of overdosage zolpidem use causes a series of withdrawal symptoms that manifest in chronological order. Additionally, long-term benzodiazepine exposure has potential influences on zolpidem dependence/tolerance. However, patients with a history of abuse or dependence, or mental disorders seem to be at risk of drug abuse. Clinicians should be alert to the potential for zolpidem dependence and addiction. Once the acute cessation of overdosage zolpidem use occurs, the potential of the withdrawal reaction needs to be considered and addressed properly.
Does health literacy promote COVID-19 awareness? Evidence from Zhejiang, China
Authors: Chen Chun , Xu Tingke , Chen Youli , Xu Yue , Ge Lizheng , Yao Dingming , Zhang Xuehai 
Published: August 2022

BackgroundHealth literacy (HL) is considered a crucial determinant of disease prevention and control. However, the role of HL in the Coronavirus Disease 2019 (COVID-19) pandemic has not been studied using provincial representative data among Chinese residents. This study aimed to assess the association between HL and COVID-19 awareness among Zhejiang residents based on the 2020 China Health Literacy Survey (CHLS).MethodsThe study was conducted among 5,596 residents aged 15–69 in Zhejiang using multistage, stratified, and probability proportional to size sampling. COVID-19 awareness and HL were assessed using the “Chinese Citizen Health Literacy Questionnaire (2020)” in Zhejiang. The covariates were divided into predisposing factors, enabling factors, and need factors according to Anderson's model. Data were analyzed by the chi-square test and logistic regression.ResultsThe study showed that HL and COVID-19 awareness levels of residents were 24.84% and 8.06%, respectively, in Zhejiang in 2020. After adjusting for covariates, residents with adequate HL were more likely to have better COVID-19 awareness (odds ratio [OR] = 5.22, 95% CI = 4.13–6.59, p &lt; 0.001). Three dimensions of HL (knowledge and attitudes, behavior and lifestyle, and health-related skills) were associated with COVID-19 awareness. Additionally, COVID-19 awareness was associated with age, occupation, family size, annual household income, and chronic conditions.ConclusionCOVID-19 awareness is significantly associated with HL, suggesting that promoting HL is an important component of health education, disease prevention, and health promotion in response to the COVID-19 pandemic and even possible public health emergencies in the future.
Association of family wellbeing with forwarding and verifying COVID-19-related information, and mediation of family communication quality
Authors: Wong Bonny Yee-Man , Ho Sai Yin , Sit Shirley Man Man , Gong Wei Jie , Lai Agnes Yuen Kwan , Wang Man Ping , Lam Tai Hing 
Published: August 2022

ObjectiveWe assessed the associations of family wellbeing with verifying and subsequently forwarding COVID-19-related information to family members and the mediating effect of the quality of family communication on these associations among Chinese adults in Hong Kong.MethodsUnder the Jockey Club SMART Family-Link Project, we conducted an online population-based survey, using Family wellbeing Scale and questions related to the family communication quality and forwarding and verifying COVID-19 information. Data were collected from 4,891 adults in May 2020. Prevalence estimates of forwarding and verifying COVID-19 information were weighted by sex, age, and education of the general population, and their associations with family wellbeing (ranged 0–10) were analyzed using generalized linear models with mutual adjustment. Their interactive effects on family wellbeing and the mediating effects of family communication quality were examined.ResultsIn total, 53.9% of respondents usually/always forwarded COVID-19 information related to their family, 68.7% usually/always verified it before forwarding, and 40.9% did both. Greater family wellbeing was associated with usually/always forwarding [adjusted β (95% CI): 0.82 (0.72–0.92)] and usually/always verifying [0.43 (0.32–0.55)] (both P &lt; 0.001) the information. Forwarding and verifying such information showed an additive effect on family wellbeing [1.25 (1.11–1.40)]. Family communication quality mediated the associations of family wellbeing with forwarding (83.7%) and verifying (86.6%) COVID-19-related information.ConclusionForwarding COVID-19 information to family, verifying such information, and especially doing both, were associated with greater family wellbeing, being strongly mediated by the quality of family communication. Individuals should be encouraged to verify COVID-19-related information before forwarding it to family members amidst the COVID-19 pandemic.
Odor recognition of deteriorated mineral oils using an odor-sensing array
Authors: Liu Yuanchang , Akagawa Sosuke , Yatabe Rui , Onodera Takeshi , Fujiwara Nobuyuki , Takeda Hidekazu , Toko Kiyoshi 
Published: August 2022

The deterioration or oxidation of the mineral oil in transformers poses the risk of short circuits. Convenient and effective methods are expected to be developed. Carbon-based sensor arrays were used in this study to identify the quality variations of mineral oil for oil-filled transformers by odors. The sensitive layers of the odor-sensing system consisted of different types of GC stationary phase materials and carbon black (CB) mixtures. We made a targeted selection of GC materials by utilizing the polarities to make a sensor array based on the distinct components of mineral oil such as alkanes and xylenes by gas chromatography mass spectrometry (GC/MS) analysis. The response characteristics of the sensitive layers were used to recognize the mineral oil odors by machine learning. With laboratory air as the carrier gas, the system could distinguish mineral oil that has been in use for over 20 years from new mineral oil with an accuracy of about 93.8%. The identification accuracy achieved was about 60% for three different concentrations of unused mineral oil and the oxidized mineral oil created by the transformer’s leakage. When detecting the oxidized mineral oil with a concentration of more than 50%, the accuracy rate reached more than 80%. The odor-sensing system in this study will help inspect mineral oils in the transformer and make leakage judgments in a short time.
Reliability of point-of-care shoulder ultrasound measurements for subacromial impingement in asymptomatic participants
Authors: Yuan Xiaoning , Lowder Ryan , Aviles-Wetherell Kathelynn , Skroce Christian , Yao Katherine V. , Soo Hoo Jennifer 
Published: August 2022

BackgroundRehabilitation is the key to management of patients with subacromial impingement syndrome to prevent disability and loss of function. While point-of-care musculoskeletal ultrasound aids clinical diagnosis of subacromial impingement syndrome, many patients do not demonstrate the classic findings of dynamic supraspinatus tendon impingement beneath the acromion on ultrasound. The objective of this study was to establish the most reliable shoulder ultrasound measurements for subacromial impingement, by evaluating the intra-rater and inter-rater reliability of measurements in asymptomatic participants.MethodsEighteen participants (9 women, 9 men, mean ± standard deviation: 34.6 ± 7.9 years of age) underwent bilateral shoulder ultrasound evaluations with measurements for subacromial impingement (acromiohumeral distance, acromion-greater tuberosity distance, supraspinatus tendon, subacromial-subdeltoid bursa, and subacromial-subdeltoid bursal fluid thickness) performed by two sports medicine physicians. Intra-class coefficients were calculated to determine the intra- and inter-rater reliability of shoulder ultrasound images and measurements.ResultsIntra-rater reliability for acromiohumeral distance (0.76–0.79), supraspinatus tendon (0.91–0.95), subacromial-subdeltoid bursa (0.76–0.84), and subacromial-subdeltoid bursal fluid thickness (0.75–0.81) was found to be good to excellent, whereas inter-rater reliability ranged from poor to moderate.ConclusionsAcromiohumeral distance in neutral position and short axis ultrasound measurements of supraspinatus tendon, subacromial-subdeltoid bursa, and subacromial-subdeltoid bursal fluid thickness in the modified Crass position were the most reliable for subacromial impingement in asymptomatic participants. We recommend validation of these measurements in a symptomatic population to aid diagnosis and direct rehabilitation of patients with suspected subacromial impingement, and to increase point-of-care ultrasound uptake, availability, and training among rehabilitation professionals across health systems.
Improved depression screening and treatment among low-income pregnant and postpartum women following Medicaid expansion in the U.S
Authors: Yoon Jangho , Harvey S. Marie , Luck Jeff 
Published: August 2022

ObjectiveThis study examined the effect of Medicaid expansion in Oregon under the Affordable Care Act on depression screening and treatment among pregnant and postpartum women who gave Medicaid-financed births.MethodsOregon birth certificates were linked to Medicaid enrollment and claims records for 2011–2016. The sample included a policy group of 1,368 women (n = 2,831) who gave births covered by pregnancy-only Medicaid in the pre-expansion period (before 2014) and full-scope Medicaid in the post-expansion period, and the comparison group of 2,229 women (n = 4,580) who gave births covered by full-scope Medicaid in both pre- and post-expansion periods. Outcomes included indicators for depression screening, psychotherapy, pharmacotherapy, and combined psychotherapy-pharmacotherapy, separately for the first, second, and third trimesters, and 2 and 6 months postpartum. This study utilized a difference-in-differences approach that compared pre-post change in an outcome for the policy group to a counterfactual pre-post change from the comparison group.ResultsMedicaid expansion led to a 3.64%-point increase in the rate of depression screening 6 months postpartum, 3.28%-point increase in the rate of psychotherapy 6 months postpartum, and 2.3 and 1%-point increases in the rates of pharmacotherapy and combined treatment in the first trimester, respectively. The relationships were driven by disproportionate gains among non-Hispanic whites and urban residents.ConclusionsExpanding Medicaid eligibility may improve depression screening and treatment among low-income women early in pregnancy and/or beyond the usual two-month postpartum period. However, it does not necessarily reduce racial/ethnic and regional gaps in depression screening and treatment.
Intestinal obstruction due to idiopathic mesenteric phlebosclerosis colitis: A case report
Authors: Shan Jiaqi , Chen Fangci , Yu Panpan 
Published: August 2022

IntroductionIdiopathic mesenteric phlebosclerosis colitis (IMP) is a rare condition that impairs colonic venous blood return owing to mesenteric venous sclerosis and fibrosis. At present, many studies have suggested that long-term intake of Chinese herbal medicines is associated with its pathogenesis. IMP has no characteristic clinical manifestations, and most patients with IMP present with acute intestinal obstruction. As a rare disease, the etiology, pathogenesis, pathophysiology, and treatment of IMP are being explored and studied.Case DescriptionA 60-year-old Chinese male patient with IMP was admitted to our hospital for acute intestinal obstruction, received subtotal colectomy and ileostomy after 10 days of ineffective conservative treatment, and was discharged after postoperative supportive treatment for 1 month.ConclusionThere are many causes of intestinal obstruction, and we report a relatively rare one. After failure of conservative treatment, it is necessary to surgically resect part of the diseased bowel.
Robotic multiquadrant colorectal procedures: A single-center experience and a systematic review of the literature
Authors: Bianchi Giorgio , Gavriilidis Paschalis , Martínez-Pérez Aleix , de’Angelis Gian Luigi , Uzzan Mathieu , Sobhani Iradj , Coccolini Federico , Schena Carlo Alberto , Carra Maria Clotilde , Spinoglio Giuseppe , de’Angelis Nicola 
Published: August 2022

PurposeRobotic surgery has been progressively implemented for colorectal procedures but is still limited for multiquadrant abdominal resections. The present study aims to describe our experience in robotic multiquadrant colorectal surgeries and provide a systematic review and meta-analysis of the literature investigating the outcomes of robotic total proctocolectomy (TPC), total colectomy (TC), subtotal colectomy (STC), or completion proctectomy (CP) compared to laparoscopy.MethodsAt our institution 16 consecutive patients underwent a 2- or 3-stage totally robotic total proctocolectomy (TPC) with ileal pouch-anal anastomosis. A systematic review of the literature was performed to select studies on robotic and laparoscopic multiquadrant colorectal procedures. Meta-analyses were used to compare the two approaches.ResultsIn our case series, 14/16 patients underwent a 2-stage robotic TPC for ulcerative colitis with a mean operative time of 271.42 (SD:37.95) minutes. No conversion occurred. Two patients developed postoperative complications. The mean hospital stay was 8.28 (SD:1.47) days with no readmissions. Mortality was nil. All patients underwent loop-ileostomy closure, and functional outcomes were satisfactory. The literature appraisal was based on 23 retrospective studies, including 736 robotic and 9,904 laparoscopic multiquadrant surgeries. In the robotic group, 36 patients underwent STC, 371 TC, 166 TPC, and 163 CP. Pooled data analysis showed that robotic TC and STC had a lower conversion rate (OR = 0.17;95% CI, 0.04–0.82; p = 0.03) than laparoscopic TC and STC. The robotic approach was associated with longer operative time for TC and STC (MD = 104.64;95% CI, 18.42–190.87; p = 0.02) and TPC and CP (MD = 38.8;95% CI, 18.7–59.06; p = 0.0002), with no differences for postoperative complications and hospital stay. Reports on urological outcomes, sexual dysfunction, and quality of life were missing.ConclusionsOur experience and the literature suggest that robotic multiquadrant colorectal surgery is safe and effective, with low morbidity and mortality rates. Nevertheless, the overall level of evidence is low, and functional outcomes of robotic approach remain largely unknown.
Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42022303016.
Pengaruh Latihan Plyometrik Terhadap Kemampuan Raihan Vertikal Jump Atlet Bolavoli Junior
Authors: Supriatna Eka 
Published: August 2022

Penelitian ini bertujuan untuk mengetahui pengaruh latihan playometrik terhadap kemampuan raihan vertical junp atlet bolavoli junior. Metode penelitian ini menggunakan metode Penelitian pra-eksperimen jenis penelitian eksperimen semu dengan sampel tidak terpisah, karena tidak dapat mengontrol semua variabel yang mempengaruhi hasil eksperimen. Desain yang digunakan dalam penelitian ini adalah “The One Group Pretest Posttest Design”. Pemilihan sampel dalam penelitian ini menggunakan teknik purposive sampling dengan jumlah atlet sebanyak 12 orang yang memiliki karakteristik sampelnya yaitu: usia dan tinggi badan yang sama. Teknik pengumpulan data menggunakan teknik Tes dan Pengukuran dengan menggunakan tes vertical jump. Teknik analisis data dalam penelitian ini menggunakan uji-t, namun ada uji persyaratan yang harus dipenuhi oleh peneliti bahwa data yang dianalisis harus berdistribusi normal, untuk itu perlu dilakukan uji normalitas dan uji homogenitas. Hasil penelitian ini menunjukan bahwa terdapat pengaruh metode latihan plyometrik secara nyata terhadap kemampuan vertikal jump pada atlet bolavoli junior, dimana t hitung >t tabel (8,75 > 1,796) dengan sumbangan pengaruh sebesar 23,3%.
Penerapan Media Audiovisual Dalam Meningkatkan Hasil Belajar Servis Bulutangkis di MTs Mujahidin Pontianak
Authors: Rubiyatno Rubiyatno , Suryadi Didi 
Published: August 2022

Penelitian ini bertujuan untuk menerapkan metodepembelajaran audiovisual pada siswa MTs Mujahidin Pontianak. Adapun permasalahan dalam penelitian ini yaitu rendahnya hasil belajar siswa khususnya dalam penguasaan teknik servis pendek bulutangkis. Berdasarkan hasil observasi peneliti terlihat bahwa rendahnya motivasi siswa pada saat mengikuti pembelajaran berimbas terhadap nilai ketuntasan KKM yang dibawah rata-rata. Untuk meningkatkan motivasi siswa tersebut peneliti mencoba menerapkan metode pembelajaran yang berbeda dari sebelumnya yaitu dengan metode audiovisual. Metode penelitian yang digunakan dalam penelitian ini yaitu dengan metode tindakan kelas yang di dalamnyat terdapat 2 siklus dengan memiliki 4 tahapan tindakan yaitu :perencanaan,pelaksanaan,observasi dan refleksi. Adapun jumlah siswa yang digunakan dalam penelitian ini sebanyak 31 siswa dengan hanya menggunakan satu kelas saja. Alat pengumpul data yang digunakan dalam penelitian ini berupa lembar observasi guru dan siswa serta instrumen penilaian proses gerak dengan kisi-kisi berupa tahapan sikap awal,sikap pelaksanaan dan sikap akhir. Berdasarkan hasil penelitian Terdapat peningkatan kemampuan servis pendek backhand bulutangkis pada siswa kelas X Sekolah Menengah Atas Mujahidin Pontianak setelah menggunakan media audiovisual yaitu pada tahap prasiklus jumlah ketuntasan hanya mencapai 32,35 %, kemudian pada siklus ke 1 meningkat menjadi 45,16% dab pada siklus ke II terjadi peningkatan yang cukup signifikan menjadi 80,64 %. Sehingga dapat disimpulkan penggunaan media pembelajaran audiovisual sangat efektif dalam meningkatkan hasil belajar servis bulutangkis.
Targeting KRAS: Crossroads of Signaling and Immune Inhibition
Authors: Kato Shumei , Fujiwara Yu , Hong David S. 
Published: August 2022

ABSTRACT
Mutations of RAS are commonly seen in human cancers, especially in lung, colorectal, and pancreatic adenocarcinoma. Despite huge effort for decades, targeting RAS mutations has been “undruggable” because of the molecular instability of RAS protein inhibition. However, the recent discovery of the KRAS G12C inhibitor paved the way to expand therapeutic options for patients with cancer harboring the KRAS G12C mutation. At the same time, the successful development of immune checkpoint inhibitors (ICIs) drastically changed the paradigm of cancer treatment and resulted in a better understanding of the tumor immune microenvironment in patients with KRAS-mutant cancer. This review describes the following: the clinical characteristics of cancer with KRAS mutation; successful development of the KRAS G12C inhibitor and its impact on the tumor immune microenvironment; and potential new avenues such as the combination strategy using KRAS inhibitor and ICI, with preclinical and clinical rationales for overcoming resistance to inhibition of KRAS to improve therapeutic efficacy for patients with cancer harboring KRAS mutations.
ANALISIS PENDEKATAN SISTEM DALAM EKONOMI ISLAM (Sebuah Pemikiran Maqashid Al-Syariah as Philosophy of Islamic Law Jasser Auda)
Authors: Matnin  , Saiban Kasuwi , Munir Misbahul 
Published: August 2022

The purpose of this study is to analyze the systems approach in Islamic economics based on maqashid al sharia thinking using the system philosophy offered by Jasser Auda.
According to him, there are at least two approaches that need to be mastered professionally at the same time, namely first, approaches that are closely related to the dimensions of time and history and second, approaches that are closely related to philosophical concepts and thoughts.
The basic concepts used by Jasser Auda in the Systems approach and analysis in Maqasid Syariah as a philosophy of Islamic law include looking at the problem as a whole (Wholeness), always being open to the possibility of improvement and refinement (Openness), interrelated-Hierarchy. , involving various dimensions (Multidimensionality) and prioritizing and prioritizing the main goal (Purposefulness).
The approach in this research is descriptive qualitative. The analysis technique used is content analysis (content analysis). Content analysis is simply defined as a method for collecting and analyzing the content of a text.
The original of this research on Islamic economics within the framework of a systems philosophy approach is Cognition (Cognitive Nature), Towards Holism, Towards Openness/Wholeness,. Interrelated Hierarchy, Multi-dimensionality, Purposefulness/Intentions.
CO Excitation and its Connection to Star Formation at 200 pc in NGC 1365
Authors: Egusa Fumi , Gao Yulong , Morokuma-Matsui Kana , Liu Guilin , Maeda Fumiya 
Published: August 2022

Abstract
We report high-resolution (2″ ∼ 200 pc) mappings of the central region of the nearby barred spiral galaxy NGC 1365 in the CO(1–0) and CO(2–1) emission lines. The 2–1/1–0 ratio of integrated intensities shows a large scatter (0.15) with a median value of 0.67. We also calculate the ratio of velocity dispersions and peak temperatures and find that in most cases the velocity dispersion ratio is close to unity and thus the peak temperature ratio is comparable to the integrated intensity ratio. This result indicates that both CO(1–0) and CO(2–1) lines trace similar components of molecular gas, with their integrated intensity (or peak temperature) ratios reflecting the gas density and/or temperature. Similar to recent kiloparsec-scale studies, these ratios show a positive correlation with a star formation rate indicator (here we use an extinction-corrected Hα map), suggesting that molecular gas associated with recent star formation is denser and/or warmer. We also find that some CO spectra show two peaks owing to complicated kinematics, and such two components likely trace molecular gas at different conditions. This result demonstrates the importance of spectral fitting to measure integrated intensities and their ratios more accurately.