bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoxia-inducible Factor Expression Is Related to Apoptosis and Cartilage Degradation in Temporomandibular Joint Osteoarthritis
Authors: Zhang Jun , Hu Yu , Wang Zihan , Wu Xuelian , Yang Chun , Yang Hefeng 
Published: January 2022

Abstract
Background: It remains unclear whether hypoxic conditions affect apoptosis and contribute to degradation of cartilaginous tissues in osteoarthritis (OA) lesions. In this study, we hypothesized that hypoxic conditions induced the accumulation of hypoxia-inducible factor (HIF) and activated apoptosis to contribute to OA cartilage degeneration in vivo.Methods: Malocclusion stress was applied for 2 weeks, 4 weeks and 8 weeks to induce an OA-like lesion animal model (OD) in rats. Histological analysis was performed by H&E staining and safranin O/fast green staining. The expression levels of protein in condylar cartilage were examined by immunostaining to evaluate cartilage degeneration.Results: We found apparent histological phenotypes associated with degeneration in the occlusion disorder stress (OD) group. The OD group at 4 weeks and 8 weeks had obviously reduced expression of Acan and Col II in cartilage. In contrast, the OD groups had higher levels of Col X, ADAMTS5 and MMP13 in the condylar cartilage than the control group. Moreover, the OD group cartilage had prominent degenerative changes with reduced levels of HIF1α and increased levels of HIF2α and the apoptosis factor Caspase3 in condylar cartilage at 8 weeks.Occlusion disorder stress results in cartilage degeneration. HIF1α and HIF2α are involved in temporomandibular joint (TMJ) cartilage homeostasis by regulating chondrocyte apoptosis, which contributes to TMJ cartilage degeneration. Conclusion: Thus, abnormal hypoxic conditions inducing opposite expression patterns of HIF1α and HIF2α could be involved in the pathogenesis of condylar cartilage degeneration. HIF2α may provide a potential negative feedback mechanism for HIF1α during cartilage damage.
Vesical Gossypiboma with Urethral Migration Causing Acute Urinary Retention: A Case Report and Review of the Literature
Authors: Gebreselassie Kaleab Habtemichael , Mummed Ferid Ousman , Gebrehiwot Fitsum Gebreegziabher , Adem Mubarek Bargicho , Adem Ramzi Yessuf , Issack Feysel Hassen 
Published: January 2022

Abstract
Introduction:

Vesical gossypiboma is a retained surgical sponge in the urinary bladder following abdominal or pelvic surgery. It is probably under-reported due to medico-legal issues. It usually poses a diagnostic challenge to clinicians. A high index of suspicion is essential to make a timely diagnosis.
Case Presentation:

We present a case of vesical gossypiboma in a 64-year-old male patient who presented with a history of persistent lower urinary tract symptoms (LUTS) and acute urinary retention following trans-vesical prostatectomy. The urinary retention was relieved by a suprapubic cystostomy. On cystoscopic examination, a large whitish spongiform structure in the urethra and bladder was revealed. A gentle attempt of cystoscopic removal was failed. At exploration, a retained surgical sponge was revealed and removed from the bladder. Postoperatively, the patient reported improvement of symptoms and was passing urine normally.
Discussion

Vesical gossypiboma is relatively rare as very few isolated cases have been reported, and its migration through the urethra is even rarer. Patients with intravesical gossypiboma may manifest with either acute or chronic symptoms due to complications. Gossypiboma is an avoidable condition, and its occurrence can be prevented by thorough exploration of the surgical site and count of surgical materials at the end of the procedure.
Conclusion

Vesical gossypiboma should be considered as a differential diagnosis in patients with persistent LUTS following open bladder or prostate surgery. Open surgical removal is one of the feasible treatment options. But prevention is a preferable solution.
Work Ability Among Long-term Breast Cancer Survivors – Exploring the Role of Social Support in a Nation-wide Study
Authors: vandraas kathrine , Falk Ragnhild Sørum , Bøhn Synne , Kiserud Cecilie , Lie Hanne , Smedsland Solveig , Ewertz Marianne , Dahl Sigrun , Brekke Mette , Reinertsen Kristin 
Published: January 2022

Abstract
work ability (WA) is scarce. We aimed to identify factors, including social support, associated with excellent WA in a nation-wide population of long-term BCS. MethodsAll long-term BCSs (20-65 years) diagnosed with early-stage BC in 2011 or 2012 were identified by the Norwegian Cancer Registry in 2019 and invited to participate in a survey (n=2803). WA was assessed using the Work Ability Index. Factors associated with excellent WA were identified using univariate and multivariate logistic regression analyses, adjusted for sociodemographic-, health- and cancer related variables. ResultsThe final sample consisted of 926 BCSs with a mean age of 56 years at survey. WA was reduced from 8.9 (SD 2.3) at diagnosis to 6.3 (SD 3.1) eight years later. One in three BCSs reported poor WA, and seven out of ten reported that their physical WA was reduced due to cancer. Survivors with excellent WA reported high social support from supervisors and colleagues compared to BCSs with low WA. Additionally, cognitive impairment and fatigue were negatively associated with WA. ConclusionWA remains a significant challenge in long-term BC survivorship, with a substantial proportion of BCSs reporting poor WA eight years after diagnosis. Collegial support appears to be a protective factor for sustained WA, whilst survivors struggling with fatigue and cognitive impairments may represent a particularly vulnerable group for discontinued employment. Increased attention to WA in follow-up care is warranted.
Validity and Reliability of the Portuguese Version of the Rapid Estimate of Adult Literacy in Dentistry - REALD-29 PT
Authors: Costa Helder , Amaral Odete , Duarte João , Correia Maria José , Veiga Nélio , López-Marcos Joaquin Francisco 
Published: January 2022

Abstract
Background

Health literacy is a main factor in health for its improvement, allowing the individuals to have a greater capacity to engage and participate in collective health promotion actions. The assessment of functional health literacy to determine the ability that each individual has to understand basic health information is essential. The aim of the present study was to translate and perform the cross-cultural adaptation of the Rapid Estimate of Adult Literacy in Dentistry (REALD-30) to Portuguese language and test the reliability and validity of this version.
Methods

The REALD-30 in the Portuguese language (REALD-29 PT) was applied to a group of individuals that participate in the program Atividade Senior, developed by the municipality of Viseu, Portugal. The final sample was composed by 206 participants that accepted responding to the questionnaire and to the REALD-30 Portuguese version (REALD-29 PT). Translation and cultural adaptation of the questionnaire and the statistical validation was accomplished in order to complete the process and obtain the REALD-29 PT.
Results

The REALD-29 PT presented good internal reliability. Cronbach’s alpha ranged from 0.89 to 0.90 when words were deleted individually. The analysis of test-retest reliability revealed excellent reproducibility. We can verify that the REALD-30 scale for assessment of oral health literacy among older adults presents an acceptable internal consistency, with a global Cronbach´s alpha of 0.894.
Conclusions

The REALD-29 PT scale can be applied to assess oral health literacy among older Portuguese adults, presenting an acceptable internal consistency and is validated to assess oral health literacy and is crucial in epidemiological studies.
Assessment of Physico-Chemical Parameters and Heavy Metal of Drinking Water Samples from Some Iranian Universities and Surveyed the Efficacy of Several Water Purification Methods on Removal of Heavy Metal
Authors: Rezaei Zeinab , Khanzadi Saeid , Shamloo Ehsan , Salari Amir 
Published: January 2022

Abstract
Water quality is the most important factor for consumers because it has a significant impact on their health. So, monitoring and controlling water quality is of particular significance in different human communities such as universities. In this study, the physicochemical parameters such as turbidity, electrical conductivity, hardness, alkalinity, calcium and magnesium ions, and heavy metals including lead, cadmium, nickel, arsenic, and chromium in drinking water were determined in nine Iranian universities. Then, the efficacy of several treatment methods was evaluated in the removal of heavy metal, including the boiling process in two stages: 5 minutes boiling and 5 hours boiling and filtration process. The results revealed that the physicochemical quality of drinking water in all universities was appropriate. Hardness levels in drinking water samples of all universities were higher than the WHO standards. However, this parameter was lower than the national standard of Iran (500 mg/l). Nevertheless, cadmium content was not detected in any samples, nickel content was below the permissible limit, and chromium content was below the permissible limit in all samples. However, its value was higher than the allowable limit in the university with a code of 6. Lead content was higher than the limit in samples with codes 3, 5-1, and 5-4, and arsenic content was higher than the limit in samples with codes 6, 1-1, 1-2, and 2. Water purification methods, including boiling and water purifier, were satisfactory and significantly reduced pollutants. According to the present study, it is suggested to check drinking water quality in universities randomly, and the 5-minute boiling method can be recommended as a cost-effective solution for water purification.
Human Pointing Motion during Interaction with an Autonomous Blimp
Authors: Hou Mengxue , Tao Qiuyang , Zhang Fumin 
Published: January 2022

Abstract
We investigate the interaction between a human and a miniature autonomous blimp using a wand as pointing device. The wand movement generated by the human is followed by the blimp through a tracking controller.The Vector Integration to Endpoint (VITE) model, previously applied to human-computer interface (HCI), has been applied to model the human generated wand movement when interacting with the blimp. We show that the closed-loop human-blimp dynamics are exponentially stable. Similar to HCI using computer mouse, overshoot motion of the blimp has been observed. The VITE model can be viewed as a special reset controller used by the human to generate wand movements that effectively reduce the overshoot of blimp motion. Moreover, we have observed undershoot motion of the blimp due to its inertia, which does not appear in HCI using computer mouse. The asymptotic stability of the human-blimp dynamics is beneficial towards tolerating the undershoot motion of the blimp.
COVID-19 pandemic, challenges, and opportunities in Northern Uganda; Community overview and perspectives: A qualitative study using informant interviews.
Authors: Ikoona Eric Nzirakaindi , Okot Christopher , Baguma Steven , Alema Nelson Onira , Oyat Freddy WD , Apiyo Paska , Layet Paska , Pebolo Francis Pebalo , Acullu Denis , Nyeko Johnson Oloya , Aloyo Judith , Kitara David Lagoro 
Published: January 2022

Abstract
Background

Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2), a virus that causes COVID-19, has overwhelmingly interrupted human activities worldwide, especially in the low-to-middle income countries. Not much is reported about exclusive challenges and opportunities presented by the COVID-19 pandemic in some remote communities in Africa.
Objective

The objective of this study was to assess the community’s views and perspectives on the challenges and opportunities of the COVID-19 pandemic in Northern Uganda.
Methods

We interviewed 36 participants (age range, 28-63 years), including health workers, civil servants, members of civil society, security forces, politicians, and staff of local government administration who were members of COVID-19 district task forces in Northern Uganda using qualitative study methods between August and September 2021. The initial selection of participants was purposeful, but the snowballing technique was later used to select others. The interview questions were pre-tested among health workers and laypersons who were not part of the main study. Participants described how the COVID-19 pandemic presented challenges and opportunities, and the experience could be used to strengthen community resolves to control the pandemic and any other in the future. A local IRB approved this study. Data were analyzed using thematic analysis.
Results

The current study findings revealed challenges but many opportunities during the COVID-19 pandemic in this community, including loss of lives and livelihoods, increased poverty, lack of personal protection equipment, uncertainties, stress, and anxiety among health workers in the community. However, it also offered opportunities for quality family time, increased engagement, sensitization, and mobilization of communities for health, improved general security of persons and property, increased budgets and logistics for government departments, reduced incidences of diarrheal diseases and road traffic accidents, increased incomes for task force members, and more interactions among members during task force meetings.
Conclusion

Although the COVID-19 pandemic presented enormous challenges to low-to-middle-income countries, there are opportunities in some communities that are worth mentioning. Information obtained in this study has practical lessons that disease control experts could use to develop strategies to organize communities better and conduct disease surveillance activities for the COVID-19 pandemic and others.
Reactions to problems in marriage
Authors: İNANÇ Betul BATTALOĞLU 
Published: January 2022

Abstract
Purpose: Violence within the family is a common problem that can be seen in almost most socio-economic groups, societies, all ages and all educational levels. This study was planned to investigate the behavior and attitudes and marital satisfaction levels of the spouses in the family life process.Methods: All citizens 18 years and older that are living in households in the Republic of Turkey have been included. Considering the existing population records, a stratified two-stage systematic cluster sampling method was applied. . Comparisons by the sex, educational level, and marital status satisfied were performed with the use of chi-square and multivariate regression analysis, correlation analysis. A p-value <0.05 was considered to be statistically significant.Result: Violent behaviors such as doing harm, breaking and hitting things were more intense in men. Physical violence was more common among males. Only maintaining silence, getting angry or sulking was statistically significant in women (p <0.000). Yelling, scolding, humiliating, separating the bedroom and decreasing spending money was statistically significant in males (p <0.000).Conclusion: All concepts related to marriage should be well defined because spouse satisfaction and conflicts can have different meanings. It suggests that raising awareness about domestic violence against women, knowing solution methods, informing about their rights and increasing social support may be beneficial in solving the problem.
Community engagement in Ebola outbreaks in sub-Saharan Africa and implications for COVID-19 control: A systematic review
Authors: Frimpong Shadrack Osei , Paintsil Elijah 
Published: January 2022

Abstract
Objectives
There is a paucity of systematic data on the specific roles community engagement played in preventing and managing the Ebola Virus Disease (EVD) outbreak in Sub-Saharan Africa (SSA). We assessed community engagement's role, benefits, and mechanisms to understand its effect on EVD case detection, survival, and mortality in SSA. Implications for COVID-19 prevention and control were also highlighted.
Methods
We systematically searched for articles between 2010 and 2020 in databases such as MEDLINE and EMBASE. Study types included were randomised trials, quasi-experimental studies, observational studies, case series, and reports.
Results
A total of 903 records were identified for screening. 216 articles met the review criteria, 103 were initially selected, and 44 were included in the final review. Our findings show that effective community involvement during the EVD outbreak depended on the survival rates, testimonials of survivors, risk perception, and community leaders’ inclusion. Community-based interventions improved knowledge and attitudes, case findings, isolation efforts and treatment.
Conclusion
Although the studies included in this review were of highly variable quality, community engagement lessons learned from Ebola outbreaks can be applied to COVID-19 pandemic control in SSA.
Evaluation Short-term Efficacy of Cervical Cancer Under Radiotherapy by Shear Wave Elastography: a Preliminary Study
Authors: Zeng Manting , Zhou Ningbo , Zhou Yangying , Wang Jian , Li Xuanxuan , Zhang Yu , Long Xueying , Zhu Hong 
Published: January 2022

Abstract
Background To find a reliable, safe, convenient and low-cost imaging technology in evaluation of the short-term clinical efficacy of cervical cancer. Here, we performed a preliminary examination of the value of shear wave elastography (SWE) in assessing short-term efficacy of radiotherapy in cervical cancer. Methods In this study, we used SWE to measure the elastic modulus of cervical masses and healthy paracervical tissues and record the maximum elastic modulus (Emax) and the mean elastic modulus (Emean) in 46 patients with cervical cancer. The 46 patients who were naive to treatment were monitored at 5 time points. We divided those into sensitive and non-sensitive groups based on MRI in combination with RECIST1.1. The relative changes in the elastic modulus of the mass before and after radiotherapy were calculated in all patients. MRI was also combined with gynecological examinations to determine if any residual masses remained. Results In this study, 25 patients completed all 5 time points examinations showing the elastic modulus of the cervix decreased while healthy paracervical tissues first increased and then decreased. Then, all 46 patients underwent SWE at 3 time points: prior to radiotherapy, the 15th radiotherapy session, and at completed radiotherapy. The results revealed that the relative changes in cervical masses in the sensitive group were larger than that in the non-sensitive group (P < 0.05). We further discovered the Emax and the Emean of cervical tissues in the residual group were higher than that in the non-residual group (135.69 ± 35.18, 128.25 ± 35.55 vs 104.13 ± 20.19, 98.14 ± 18.9, respectively; P < 0.05), and the area under the curve (AUCs) of the receiver operating characteristic (ROC)were 0.770 and 0.767, respectively (P < 0.05). Conclusions SWE can be used to monitor changes in cervix and paracervical stiffness, and to assist in assessments of the efficacy of radiotherapy in cervical cancer.
QUBO Formulations for a System of Linear Equations
Authors: Jun Kyungtaek 
Published: January 2022

Abstract
With the advent of quantum computers, many quantum computing algorithms are being developed. Solving linear systems is one of the most fundamental problems in almost all of science and engineering. Harrow-Hassidim-Lloyd algorithm, a monumental quantum algorithm for solving linear systems on the gate model quantum computers, was invented and several advanced variations have been developed. For a given square matrix A∈R(n×n) and a vector b∈R(n), we will find unconstrained binary optimization (QUBO) models for a vector x∈R(n) that satisfies Ax=b. To formulate QUBO models for a linear system solving problem, we make use of a linear least-square problem with binary representation of the solution. We validate those QUBO models on the D-Wave system and discuss the results. For a simple system, We provide a python code to calculate the matrix characterizing the relationship between the variables and to print the test code that can be used directly in D-Wave system.
Identification of QTLs and Putative Candidate Gene Involved in Rhizome Enlargement of Asian lotus (Nelumbo Nucifera)
Authors: Liu Yanling , Song Heyun , Zhang Minghua , Yang Dong , Deng Xianbao , Sun Heng , Liu Juan , Yang Mei 
Published: January 2022

Abstract
Lotus (Nelumbo) is perennial aquatic plant with nutritional, pharmacological, and ornamental significance. Rhizome is an underground lotus stem that act as a storage organ and as a reproductive tissue for asexual production. The enlargement of lotus rhizome is an important adaptive strategy for surviving the cold winter. The aims of this study were to identify quantitative trait loci (QTLs) for rhizome enlargement traits including rhizome enlargement index (REI) and number of enlarged rhizome (NER), and to uncover candidate genes associated with these phenotypic traits. A high-density genetic linkage map was constructed, consisting of 2,935 markers binned from 236,840 SNPs. A total of 14 significant QTLs were detected for REI and NER, which explained 6.67–22.28% of trait variance. Three QTL regions were repeatedly identified in at least two years, and a major QTL, designated cqREI-LG2, with a rhizome-enlargement effect and about 20% of the phenotypic contribution was identified across the three climatic years. A candidate NnBEL6 gene located within the confidence interval of cqREI-LG2 was considered to be putatively involved in lotus rhizome enlargement. The expression of NnBEL6 was exclusively induced by rhizome swelling. Sequence comparison of NnBEL6 among lotus varieties revealed a functional Indel site in its promoter that likely initiates the rhizome enlargement process. Transgenic potato assay was used to confirm the role of NnBEL6 in inducing tuberization. The successful identification QTLs and functional validation of NnBEL6 gene reported in this study will enrich our knowledge on the genetic basis of rhizome enlargement in lotus.