bluuebunny/crossref_metadata_2025_split huggingface dataset:
The additive effect of periodontitis with hypertension on risk of systemic disease and mortality
Authors: Larvin Harriet , Kang Jing , Aggarwal Vishal R. , Pavitt Sue , Wu Jianhua 
Published: April 2022

AbstractBackgroundRecent evidence suggests that periodontitis (PD) causes hypertension, which is a precursor to development of other systemic diseases. The aim of this study was to examine the effect of hypertension and PD on the risk of subsequent systemic disease.MethodsThis longitudinal cohort study included 244,393 UK Biobank participants who were free of systemic disease other than hypertension at baseline. Self‐reported responses of painful gums or loose teeth were surrogates for PD. Hypertensives were identified by clinical diagnosis, or elevated blood pressure (≥140/90 mmHg). Systemic diseases including cancer, cardiovascular disease (CVD), and diabetes were identified from linked diagnostic codes. Multivariable Cox proportional hazard models were used to quantify the risk of systemic diseases and all‐cause mortality, stratified by hypertensive and PD status.ResultsThe average age of the study population was 55.4 years (standard deviation [SD:] 8.1 years), and 130,220 (53.3%) participants were female. At baseline, 131,566 (53.8%) participants were hypertensive and 4.5% reported PD. The incidence rates of all systemic diseases were higher in hypertensive than non‐hypertensive participants of the same PD status. In hypertensives, an additive effect was observed for PD on the risks of CVD (adjusted hazard ratio [HR]: 1.35, 95% confidence interval [CI]: 1.21–1.53) and respiratory disease (HR: 1.11, 95% CI: 0.95–1.30) compared to hypertensive healthy controls.ConclusionsHypertensives with PD have exacerbated risks of several systemic diseases. Future interventional studies should consider the effect of periodontal treatment on systemic outcomes in targeted hypertensive populations.
The impact of probiotic yogurt versus ordinary yogurt on serum sTWEAK, sCD163, ADMA, LCAT and BUN in patients with chronic heart failure: a randomized, triple‐blind, controlled trial
Authors: Pourrajab Behnaz , Naderi Nasim , Janani Leila , Hajahmadi Marjan , Mofid Vahid , Dehnad Afsaneh , Sohouli Mohammad Hassan , Hosseini Sharieh , Shidfar Farzad 
Published: April 2022

AbstractBackgroundTo date, no study has investigated the effects of probiotic yogurt as a functional food in patients with chronic heart failure (CHF). Therefore, the aim of this study was to compare the impact of probiotic yogurt versus ordinary yogurt on inflammatory, endothelial, lipid and renal indices in CHF patients. In this randomized, triple‐blind clinical trial, 90 patients with CHF were randomly allocated into two groups to take either probiotic or ordinary yogurt for 10 weeks. Serum levels of soluble tumor necrosis factor‐like weak inducer of apoptosis (sTWEAK), soluble cluster of differentiation 163 (sCD163), asymmetric dimethylarginine (ADMA), and lecithin cholesterol acyltransferase (LCAT) were measured by using ELISA kits, and blood urea nitrogen (BUN) was measured by calorimetry method at baseline and at the end of trial. The P‐value <0.05 was defined as statistically significant.ResultsSeventy‐eight patients completed the study. At the end of the intervention, the levels of sTWEAK in both groups increased significantly, and this increase was greater in the probiotic yogurt group [691.84 (335.60, 866.95)] compared to control group [581.96 (444.99, 929.40)], and the difference between the groups was statistically significant after adjusting for confounders (P‐value: 0.257, adjusted P‐value: 0.038). However, no significant differences were found between the groups in the cases of other study indices.ConclusionProbiotic yogurt may be useful for improving the inflammatory status in patients with CHF through increasing sTWEAK levels, however, further studies are needed in this area. © 2022 Society of Chemical Industry.
In vivo fluid transport in human intervertebral discs varies by spinal level and disc region
Authors: Martin John T. , Wesorick Benjamin , Oldweiler Alexander B. , Kosinski Andrzej S. , Goode Adam P. , DeFrate Louis E. 
Published: April 2022

AbstractBackgroundThe lumbar discs are large, dense tissues that are primarily avascular, and cells residing in the central region of the disc are up to 6–8 mm from the nearest blood vessel in adults. To maintain homeostasis, disc cells rely on nutrient transport between the discs and adjacent vertebrae. Thus, diminished transport has been proposed as a factor in age‐related disc degeneration.MethodsIn this study, we used magnetic resonance imaging (MRI) to quantify diurnal changes in T2 relaxation time, an MRI biomarker related to disc hydration, to generate 3D models of disc fluid distribution and determine how diurnal changes in fluid varied by spinal level. We recruited 10 participants (five males/five females; age: 21–30 years; BMI: 19.1–29.0 kg/m2) and evaluated the T2 relaxation time of each disc at 8:00 AM and 7:00 PM, as well as degeneration grade (Pfirrmann). We also measured disc height, volume, and perimeter in a subset of individuals as a preliminary comparison of geometry and transport properties.ResultsWe found that the baseline (AM) T2 relaxation time and the diurnal change in T2 relaxation time were greatest in the cranial lumbar discs, decreasing along the lumbar spine from cranial to caudal. In cranial discs, T2 relaxation times decreased in each disc region (nucleus pulposus [NP], inner annulus fibrosus [IAF], and outer annulus fibrosus [OAF]), whereas in caudal discs, T2 relaxation times decreased in the NP but increased in the AF.ConclusionsFluid transport varied by spinal level, where transport was greatest in the most cranial lumbar discs and decreased from cranial to caudal along the lumbar spine. Future work should evaluate what level‐dependent factors affect transport.
Ligand fishing based on tubular microchannel modified with monoamine oxidase B for screening of the enzyme's inhibitors from Crocus sativus and Edgeworthia gardneri
Authors: Qi Xu‐Wei , Liu Yi‐Ming , Hu Yi‐Kao , Yuan Hao , Ayeni Emmanuel Ayodeji , Liao Xun 
Published: April 2022

A novel strategy of performing ligand fishing with enzyme‐modified open tubular microchannel was proposed for screening bioactive components present in medicinal plants. Monoamine oxidase B was immobilized onto the surface of the microchannel for the first time to specifically extract its ligands when the plant's extracts solution flows through the channel. The thermal and the storage stability of immobilized monoamine oxidase B were significantly enhanced after immobilization. Crocin I and Ⅱ were extracted from Crocus sativus, and tiliroside was extracted from Edgeworthia gardneri. All the three compounds were inhibitors of the enzyme with the half‐maximal inhibitory concentration values of 26.70 ± 0.91, 19.88 ± 2.78, and 15.65 ± 0.85 μM, respectively. The enzyme inhibition kinetics and molecular docking were investigated. This is the first report on the inhibitory effects of tiliroside and crocin Ⅱ. The novel ligand fishing method proposed in this work possesses advantages of rapidness, high efficiency, and tiny sample consumption compared to routine ligand fishing, with promising potential for screening active natural products in complex mixtures.
Ultrasound‐Estimated Bladder Weight Correlates With Videourodynamic Studies in Neurogenic Bladder Dysfunction
Authors: Hwang Misun , Back Susan J. , Van Batavia Jason , Tierradentro‐Garcia Luis Octavio , Darge Kassa , Zderic Stephen A. 
Published: April 2022

PurposeThis retrospective study was designed to evaluate which lower urinary tract ultrasound parameter(s) could predict the results of invasive urodynamic testing which are the current reference standard in the evaluation of bladder dysfunction in children with spina bifida.Materials and MethodsFifty eight children with spina bifida undergoing video urodynamic evaluation and a renal bladder ultrasound as their standard of care were evaluated. Quantitative and qualitative ultrasound parameters were then correlated with the videourodynamic study results which served as the reference standard.ResultsFor bladders with ending storage pressures above 15 cm H2O, there were increases in these ultrasound measured parameters: 1) bladder mass (P = .00019), 2) bladder/body mass ratio (P = .0059), and 3) wall thickness (P = .01). We defined the storage cost as the final storage pressure divided by the percentage of expected bladder capacity attained. These data were analyzed to compute receiver operating curves with assuming end storage pressures cutoff points of 15, 20, 30, and 40 cm H2O. The optimal area under the curve was found for a bladder weight of 65 g and a pressure cutoff of 30 cm H2O with a sensitivity of 75% with a specificity of 84%.ConclusionBladder weight is independent of luminal volume, can be normalized to body weight, and may serve as a clinically valuable tool for noninvasive screening to define a subset of patients with neurogenic bladder with a higher likelihood of having abnormal videourodynamic results.
Endoscope‐Assisted Resection of Benign Parotid Tumors via Concealed Post‐Auricular Sulcus Incision
Authors: Dong Yuke , Zhang Junbo , Li Yujie , Huang Wei , Dang Yanwei , Gong Wendan , Shen Xiao , Xu Lianfang 
Published: April 2022

ObjectivesTo investigate the feasibility, safety, and effectiveness of endoscopic‐assisted resection of benign parotid tumors via concealed post‐auricular sulcus incision.MethodsBetween October 2019 and March 2021, eligible patients with diagnosed benign parotid tumors were prospectively included and randomly assigned to two groups: the endoscope‐assisted post‐auricular sulcus incision group (endoscope group) and the conventional Blair “S” incision group (conventional group).ResultsA total of 45 patients were finally included, including 24 subjects in the endoscope group and 21 subjects in the conventional group. No obvious differences were observed in basic information between these two groups of patients. The surgical incision length in endoscope group patients was 4.0 ± 0.4 cm, which was significantly shorter than that in conventional group patients, 10.3 ± 1.6 cm (p < 0.001). The total intraoperative blood loss, the first post‐operative day drainage volume, the total post‐operative drainage volume, and the total drainage days were all significantly lower in endoscope group patients than in conventional group patients (all p < 0.05). Among 3 months follow‐ups, no local recurrence or residual tumor were found in both groups of patients, and there were none of them had permanent facial paralysis or parotid fistula. The self‐evaluated appearance satisfaction VAS scores of endoscope group patients were all 0, which was significantly lower than that of conventional group patients, 4.7 ± 1.6 (p < 0.001).ConclusionCompared with the conventional Blair “S” incision surgery, the endoscope‐assisted resection of the benign parotid tumors via concealed post‐auricular sulcus incision was safe and effective and showed advantages of faster recovery and better self‐assessments of appearance satisfaction.Level of Evidence2 Laryngoscope, 133:133–138, 2023
An algorithm for detecting and quantifying disturbance and recovery in high‐frequency time series
Authors: Walter Jonathan A. , Buelo Cal D. , Besterman Alice F. , Tassone Spencer J. , Atkins Jeff W. , Pace Michael L. 
Published: April 2022

AbstractDetermining when a disturbance has occurred, its severity, and when the system recovered, is important to numerous questions in the aquatic sciences. This problem can be conceptualized as the timing and degree of perturbation from a typical state, and when the system returns to that typical state. We present an algorithm for detecting disturbance and recovery designed for high‐frequency time series, e.g., data produced by automated sampling devices in instrumented buoys and flux towers. The algorithm quantifies differences in the empirical cumulative distribution functions of moving windows over reference and evaluation periods, and is sensitive to changes in the mean, variance, and higher statistical moments. Tests on simulated data show it accurately identifies disturbance and recovery. Three case studies illustrate the application of our algorithm in different empirical settings. A case study on dissolved oxygen in a Florida, USA estuary following a hurricane identified the disturbance and recovery 73 d later. A case study on air temperature and net ecosystem exchange in the Florida everglades identified cold snaps coinciding with periods of reduced carbon uptake. A case study on rotifer abundance following zebra mussel invasion in the Hudson River, NY showed rotifer collapse following invasion and recovery over a decade later. Methods such as ours can improve understanding response to disturbance and facilitate comparative and synthetic study of disturbance impacts across ecosystems.
Simultaneous Detection of Spin and Orbital Angular Momentum of Light through Scattering from a Single Silver Nanowire
Authors: Paul Diptabrata , Sharma Deepak K , Kumar G. V. Pavan 
Published: April 2022

AbstractIn recent times the spin angular momentum (SAM) and orbital angular momentum (OAM) of light have gained prominence because of their significance in optical communication systems, micromanipulation, and sub‐wavelength position sensing. To this end, simultaneous detection of SAM and OAM of light beam is one of the important topics of research from both application and fundamental spin‐orbit interaction (SOI) point of view. While interferometry and metasurface based approaches have been able to detect the states, the presented approach involves elastic scattering from a monocrystalline silver nanowire for the simultaneous detection of SAM and OAM state of a circularly polarized Laguerre–Gaussian beam. By employing Fourier plane (FP) microscopy, the transmitted scattered light intensity distribution in the FP is analyzed to reconstruct the SAM and OAM state unambiguously. The SAM and OAM induced transverse energy flow as well as the polarization dependent scattering characteristics of the nanowire is investigated to understand the detection mechanism. This method is devoid of complex nanofabrication techniques and to the authors' knowledge, is a first example of single nano‐object based simultaneous SAM and OAM detection. The study will further the understanding of SOI effects and can be useful for on‐chip optical detection and manipulation.
Tribological properties of borate ionic liquids with low corrosion grade and excellent thermal stability in 500 N base oil
Authors: Wang Feiming , Gao Xing , Zang Shuliang , Deng Guichun , Yue Shuang 
Published: April 2022

AbstractTwo borate ionic liquids 1‐Butyl‐3‐(2‐methoxy‐2‐oxoethyl)‐imidazole bis(mandelato)‐borate [MABIM][BMB]) and 1,3‐Dioctylbenzotriazole bis(mandelato)‐borate ([DOBI][BMB]) were synthesised and utilised as the lubricating additives. Their corrosion degrees were measured and the results show that [DOBI][BMB] and [MABIM][BMB] exhibit remarkable anti‐corrosion properties ([DOBI][BMB]: 1a, [MABIM][BMB]: 1b). The 4‐ball machine was employed to evaluate their tribological properties in 500 N base oil. When [DOBI][BMB] and [MABIM][BMB] were added at the concentration of 3.0 wt%, the friction coefficient of 500 N was reduced by 37.5% and 29.5%. It can be concluded from the results of XPS and SEM that a lubricating film containing iron oxide, B2O3 and organic N‐containing compounds have formed. And a model is proposed so as to describe the lubricating mechanism.
Global strong solutions and large‐time behavior of 2D tropical climate model with zero thermal diffusion
Authors: Niu Dongjuan , Wu Huiru 
Published: April 2022

In this article, we study the global well‐posedness and large‐time behaviors of solutions to the two‐dimensional tropical climate system with zero thermal diffusion for small initial data in the whole space. The main approaches include high‐ and low‐frequency decomposition method and exploiting the structure of system (1) to obtain the estimates of thermal dissipation. We utilize the time decay properties of the kernels to a linear differential equation to obtain the decay rates of solutions of the low‐frequency part and the decay property of exponential operator for the high‐frequency part. The key ingredient here is the explicit large‐time decay rate of solutions.
Metabolic pathways utilized by the porcine conceptus, uterus, and placenta
Authors: Johnson Gregory A. , Seo Heewon , Bazer Fuller W. , Wu Guoyao , Kramer Avery C. , McLendon Bryan A. , Cain Joe W. 
Published: April 2022

AbstractConceptus elongation and early placentation involve growth and remodeling that requires proliferation and migration of cells. This demands conceptuses expend energy before establishment of a placenta connection and when they are dependent upon components of histotroph secreted or transported into the uterine lumen from the uterus. Glucose and fructose, as well as many amino acids (including arginine, aspartate, glutamine, glutamate, glycine, methionine, and serine), increase in the uterine lumen during the peri‐implantation period. Glucose and fructose enter cells via their transporters, SLC2A, SLC2A3, and SLC2A8, and amino acids enter the cells via specific transporters that are expressed by the conceptus trophectoderm. However, porcine conceptuses develop rapidly through extensive cellular proliferation and migration as they elongate and attach to the uterine wall resulting in increased metabolic demands. Therefore, coordination of multiple metabolic biosynthetic pathways is an essential aspect of conceptus development. Oxidative metabolism primarily occurs through the tricarboxylic acid (TCA) cycle and the electron transport chain, but proliferating and migrating cells, like the trophectoderm of pigs, enhance aerobic glycolysis. The glycolytic intermediates from glucose can then be shunted into the pentose phosphate pathway and one‐carbon metabolism for the de novo synthesis of nucleotides. A result of aerobic glycolysis is limited availability of pyruvate for maintaining the TCA cycle, and trophectoderm cells likely replenish TCA cycle metabolites primarily through glutaminolysis to convert glutamine into TCA cycle intermediates. The synthesis of ATP, nucleotides, amino acids, and fatty acids through these biosynthetic pathways is essential to support elongation, migration, hormone synthesis, implantation, and early placental development of conceptuses.
Offspring of hyper prolific sows: Immunity, birthweight, and heterogeneous litters
Authors: Oliviero Claudio 
Published: April 2022

AbstractIn Europe, in the last 3 decades, there has been a constant increase in litter size due to the use of superior maternal line genetics. Those sows giving birth to more piglets than their average number of functional teats are identified as hyperprolific sows (HPS). The large number of piglets born within a litter implies not only a challenge for their access to vital resources like colostrum and milk but has a direct effect on their average birth weight and heterogeneity. These conditions are detrimental to piglets' vitality in the first hours of life and also to their immunity development. An exceptionally large number of growing fetuses in HPS leads to intrauterine crowding and consequently to an increased number of piglets suffering from intrauterine growth retardation (IUGR), which put piglets at a high risk of mortality after birth and up to later stages of life. Increased heterogeneity of birth weight within large litters increases the competition for colostrum intake, with the smaller piglets being less competitive and vital, and therefore affecting negatively their immunity. Low birth weight, long interval to reach the udder, and long duration of farrowing, all have negative effects on piglets' immunoglobulin absorption. In HPS litters, colostrum management should be focused on low birth weight piglets, anticipating their impaired capabilities associated with ingesting adequate colostrum, by shortening the time to reach the udder and reducing competition among piglets. The vitality of neonate piglets, especially low in birth weight or affected by IUGR should be enhanced to improve their body temperature and their early life stage energy metabolism.
Nonnegative canonical tensor decomposition with linear constraints: nnCANDELINC
Authors: Alexandrov Boian , DeSantis Derek F. , Manzini Gianmarco , Skau Erik W. 
Published: April 2022

AbstractThere is an emerging interest for tensor factorization applications in big‐data analytics and machine learning. To speed up the factorization of extra‐large datasets, organized in multidimensional arrays (also known as tensors), easy to compute compression‐based tensor representations, such as, Tucker and tensor train formats, are used to approximate the initial large‐tensor. Further, tensor factorization is used to extract latent features that can facilitate discoveries of new mechanisms and signatures hidden in the data, where the explainability of the latent features is of principal importance. Nonnegative tensor factorization extracts latent features that are naturally sparse and parts of the data, which makes them easily interpretable. However, to take into account available domain knowledge and subject matter expertise, often additional constraints need to be imposed, which lead us to canonical decomposition with linear constraints (CANDELINC), a canonical polyadic decomposition with rank deficient factors. In CANDELINC, Tucker compression is used as a preprocessing step, which lead to a larger residual error but to more explainable latent features. Here, we propose a nonnegative CANDELINC (nnCANDELINC) accomplished via a specific nonnegative Tucker decomposition; we refer to as minimal or canonical nonnegative Tucker. We derive several results required to understand the specificity of nnCANDELINC, focusing on the difficulties of preserving the nonnegative rank of a tensor to its Tucker core and comparing the real valued to nonnegative case. Finally, we demonstrate nnCANDELINC performance on synthetic and real‐world examples.
Identified gamification opportunities for digital patient journey solution during an arthroplasty journey: secondary analysis of patients' interviews
Authors: Jansson Johanna , Laukka Elina , Kanste Outi , Koivisto Jonna , Jansson Miia 
Published: April 2022

AbstractAimThe use of gameful design for supporting health‐related behaviours has been one of the major trends in health technology. An opportunity to increase engagement and motivation in a given health behaviour and the possibility of reaching improved outcomes through continued or consistent behaviour could be provided by gamification. This study aimed to identify gamification opportunities for digital patient journey solutions to increase patients' engagement and motivation for health‐related behaviour during an arthroplasty journey.DesignA secondary analysis.MethodSemistructured interviews were performed among 20 elective primary total hip and knee arthroplasty patients in a single joint‐replacement centre in Finland during autumn 2018. NVivo software was used for deductive content analysis. The study was conducted among 20 patients in a single joint replacement centre during 2018.ResultsSeveral opportunities for gamification were identified for digital patient journey solutions, which could be used in advanced care to increase patients' engagement and motivation for health‐related behaviour during the arthroplasty journey. These opportunities were identified related to five dimensions: accomplishment, challenge, guided, playfulness and social experience. Clear, scheduled, progressive and personalized goals with an activity tracking, real‐time timespan visualization and social networking with peers, support networks and healthcare providers could be provided. Opportunities for competition and immersion were not identified.