bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience with radiopharmacy information system
Authors: Perales Jesús Luis Gómez 
Published: July 2022

Abstract
Background
The efficient management of hospital radiopharmacy is very important for a good workflow in nuclear medicine and essential to ensure the correct traceability of the radiopharmaceuticals administered to patients. In the hospital radiopharmacy of our nuclear medicine department, it was developed and implemented a radiopharmacy information system (Radiolab).

Results
From its implementation, important additional functionalities have been added to this software application, according to our requirements and according as well to some of the specific requirements proposed in a recently published consensual tool for validating radiopharmacy software. After more than ten years from the implementation of this software application, it has been analysed its contribution to our hospital radiopharmacy and nuclear medicine department.

Conclusions
As a result, this radiopharmacy information system provides comprehensive management of our hospital radiopharmacy in an efficient way, and reliable traceability of every dose of radiopharmaceutical administered in our nuclear medicine department.
Effect of welding parameters on the mechanical and metallurgical properties of armor steel weldment
Authors: Morsy M. A. , Abdel Aziz Sabry M. , Abdelwahed Khaled , Abdelwahab Sabreen A. 
Published: July 2022

AbstractThe effect of welding parameters on the mechanical and metallurgical properties of armor steel weldment was studied using gas tungsten arc welding process with two filler wires: carbon steel and austenitic stainless-steel filler wires (AWS A5.18 ER 70S-6 and AWS A5.9 ER 307, respectively). The joint configurations were mainly single V and single bevel grooves. Using both AWS A5.18 ER70S-6 carbon steel filler wire and AWS A5.9 ER307, austenitic filler wire for the two joints passed the required tensile strength by the military standard. The joints successfully regained the base metal hardness at a distance of less than 15 mm. The ultimate tensile strength of the joints welded in a single bevel groove is 906 MPa which is higher than the joints welded using a single V groove is 865 MPa. This could be attributed to the increase in dilution percentage with the single bevel joints. Both single V joint and single bevel joints passed the required Charpy V-notch impact test whether using both carbon and stainless-steel wires. The effect of heat input and cooling rate on the mechanical and microstructure of welded joints was studied. The reduction of heat input caused a narrow HAZ with a small reduction in its hardness values with much reduction in the width of softening microstructure zone. SEM observations show that the base metal has a martensitic structure, but the weld metal microstructures depend on the filler: carbon steel or austenitic steel types. Using a single bevel groove with an austenitic steel filler metal, the weld metal shows a martensitic/austenitic microstructure by SEM observation, and this was verified by the Schaeffler diagram which showed a high dilution percentage (about 35% dilution). This resulted in a significant increase in joint strength and a higher weld metal impact resistance.
Identification of Preanesthetic History Elements by a Natural Language Processing Engine
Authors: Suh Harrison S. , Tully Jeffrey L. , Meineke Minhthy N. , Waterman Ruth S. , Gabriel Rodney A. 
Published: July 2022

BACKGROUND:
Methods that can automate, support, and streamline the preanesthesia evaluation process may improve resource utilization and efficiency. Natural language processing (NLP) involves the extraction of relevant information from unstructured text data. We describe the utilization of a clinical NLP pipeline intended to identify elements relevant to preoperative medical history by analyzing clinical notes. We hypothesize that the NLP pipeline would identify a significant portion of pertinent history captured by a perioperative provider.

METHODS:
For each patient, we collected all pertinent notes from the institution’s electronic medical record that were available no later than 1 day before their preoperative anesthesia clinic appointment. Pertinent notes included free-text notes consisting of history and physical, consultation, outpatient, inpatient progress, and previous preanesthetic evaluation notes. The free-text notes were processed by a Named Entity Recognition pipeline, an NLP machine learning model trained to recognize and label spans of text that corresponded to medical concepts. These medical concepts were then mapped to a list of medical conditions that were of interest for a preanesthesia evaluation. For each condition, we calculated the percentage of time across all patients in which (1) the NLP pipeline and the anesthesiologist both captured the condition; (2) the NLP pipeline captured the condition but the anesthesiologist did not; and (3) the NLP pipeline did not capture the condition but the anesthesiologist did.

RESULTS:
A total of 93 patients were included in the NLP pipeline input. Free-text notes were extracted from the electronic medical record of these patients for a total of 9765 notes. The NLP pipeline and anesthesiologist agreed in 81.24% of instances on the presence or absence of a specific condition. The NLP pipeline identified information that was not noted by the anesthesiologist in 16.57% of instances and did not identify a condition that was noted by the anesthesiologist’s review in 2.19% of instances.

CONCLUSIONS:
In this proof-of-concept study, we demonstrated that utilization of NLP produced an output that identified medical conditions relevant to preanesthetic evaluation from unstructured free-text input. Automation of risk stratification tools may provide clinical decision support or recommend additional preoperative testing or evaluation. Future studies are needed to integrate these tools into clinical workflows and validate its efficacy.
Engineering the thin film characteristics for optimal performance of superconducting kinetic inductance amplifiers using a rigorous modelling technique
Authors: Tan Boon-Kok , Boussaha Faouzi , Chaumont Christine , Longden Joseph , Navarro Montilla Javier 
Published: July 2022

Background: Kinetic Inductance Travelling Wave Parametric Amplifiers (KITWPAs) are a new variant of superconducting amplifier that can potentially achieve high gain with quantum-limited noise performance over broad bandwidth, which is important for many ultra-sensitive experiments. In this paper, we present a novel modelling technique that can better capture the electromagnetic behaviour of a KITWPA without the translation symmetry assumption, allowing us to flexibly explore the use of more complex transmission line structures and better predict their performance. Methods: In order to design a KITWPA with optimal performance, we investigate the use of different superconducting thin film materials, and compare their pros and cons in forming a high-gain low-loss medium feasible for amplification. We establish that if the film thickness can be controlled precisely, the material used has less impact on the performance of the device, as long as it is topologically defect-free and operating within its superconducting regime. With this insight, we propose the use of Titanium Nitride (TiN) film for our KITWPA as its critical temperature can be easily altered to suit our applications. We further investigate the topological effect of different commonly used superconducting transmission line structures with the TiN film, including the effect of various non-conducting materials required to form the amplifier. Results: Both of these comprehensive studies led us to two configurations of the KITWPA: 1) A low-loss 100 nm thick TiN coplanar waveguide amplifier, and 2) A compact 50 nm TiN inverted microstrip amplifier. We utilise the novel modelling technique described in the first part of the paper to explore and investigate the optimal design and operational setup required to achieve high gain with the broadest bandwidth for both KITWPAs, including the effect of loss. Conclusions: Finally, we conclude the paper with the actual layout and the predicted gain-bandwidth product of our KITWPAs.
Deriving alpha angle from anterior-posterior dual-energy x-ray absorptiometry scans: an automated and validated approach
Authors: Faber Benjamin G. , Ebsim Raja , Saunders Fiona R. , Frysz Monika , Davey Smith George , Cootes Timothy , Tobias Jonathan H. , Lindner Claudia 
Published: July 2022

Introduction: Alpha angle (AA) is a widely used imaging measure of hip shape that is commonly used to define cam morphology, a bulging of the lateral aspect of the femoral head. Cam morphology has shown strong associations with hip osteoarthritis (OA) making the AA a clinically relevant measure. In both clinical practice and research studies, AA tends to be measured manually which can be inconsistent and time-consuming. Objective: We aimed to (i) develop an automated method of deriving AA from anterior-posterior dual-energy x-ray absorptiometry (DXA) scans; and (ii) validate this method against manual measures of AA. Methods: 6,807 individuals with left hip DXAs were selected from UK Biobank. Outline points were manually placed around the femoral head on 1,930 images before training a Random Forest-based algorithm to place the points on a further 4,877 images. An automatic method for calculating AA was written in Python 3 utilising these outline points. An iterative approach was taken to developing and validating the method, testing the automated measures against independent batches of manually measured images in sequential experiments. Results: Over the course of six experimental stages the concordance correlation coefficient, when comparing the automatic AA to manual measures of AA, improved from 0.28 [95% confidence interval 0.13-0.43] for the initial version to 0.88 [0.84-0.92] for the final version. The inter-rater kappa statistic comparing automatic versus manual measures of cam morphology, defined as AA ³≥60°, improved from 0.43 [80% agreement] for the initial version to 0.86 [94% agreement] for the final version. Conclusions: We have developed and validated an automated measure of AA from DXA scans, showing high agreement with manually measuring AA. The proposed method is available to the wider research community from Zenodo.
A randomised, prospective and head-to-head comparison of [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 for the detection of recurrent prostate cancer in PSMA-ligand PET/CT—Protocol design and rationale
Authors: Alberts Ian , Bütikofer Lukas , Rominger Axel , Afshar-Oromieh Ali 
Published: July 2022

Background
A number of radiopharmaceuticals are available for the detection of recurrent prostate cancer (rPC), but few comparative imaging trials have been performed comparing them. In particular, there are no prospective head-to-head comparisons of the recently introduced [18F]PSMA-1007 to the existing standard of care [68Ga]Ga-PSMA-11. The purpose of this trial is to establish the non-inferiority of the new radiopharmaceutical in terms of the rate of PET-positive findings and to obtain an intra-individual comparison of accuracy and radiopharmaceutical kinetics.

Methods
In this cross-over trial we will randomise 100 individuals to receive either first a standard-of-care PET/CT using [68Ga]Ga-PSMA-11 followed by an additional [18F]PSMA-1007 PET/CT within 2 weeks, or vice-versa. Inclusion criteria include patients 18 years and older with biochemical recurrence of prostate cancer following radical prostatectomy, defined as two consecutive prostate specific antigen (PSA) levels > 0.2 ng/ml. Detection rate at the patient-based level is the primary end-point. Each scan will be interpreted by a panel of six independent and masked readers (three for [68Ga]Ga-PSMA-11 and three for [18F]PSMA-1007) which consensus majority in cases of discrepancy. To confirm the PET-positivity rate at a patient based level, follow up at 6 months following the first scan will be performed to a composite standard of truth. Secondary endpoints shall include an intra-individual comparison of radiopharmaceutical-kinetics, per-region detection rate and positive predictive value.

Discussion
This is the first randomised prospective comparative imaging trial to compare the established [68Ga]Ga-PSMA-11 with [18F]PSMA-1007 and will determine whether the new radiopharmaceutical is non-inferior to the established standard-of-care in terms of patient-level detection rate.

Clinical trial registration
Registered with and approved by the regional ethics authority #2020–02903 (submitted 09.12.2020, approval 16.12.2021) and the regulatory authority SwissMedic 2020DR2103. Registered with ClinicalTrials.gov Identifier NCT05079828 and additionally in a national language in the Swiss National Clinical Trials Portal (SNCTP).
Book Review, Immigrant Japan: Mobility and Belonging in an Ethno-nationalist Society, by Gracia Liu-Farrer
Authors: Budianto Firman 
Published: July 2022

Gracia Liu-Farrer’s Immigrant Japan: Mobility and Belonging in an Ethno-Nationalist Society is an intellectually stimulating invitation to rethink the traditional definition of immigrant country in an age of global mobility. The book provides the readers with rich narratives to understand how the immigration takes place in an immigrant society that emerged out of an ethno-nationalist one. Through the analysis of narratives of belonging and mobility, Liu-Farrer has shown how international migration occurs in non-traditional receiving countries, challenged the traditional definition of an immigrant country, and offered a promise of future Japan as an immigrant country. The book presents an essential addition to the literature on Japanese studies, area studies, and international migration and mobilities in Japan and beyond. It shows that micro-level individual narratives on mobility could pave the way to understanding transnationalism and connectivity at a larger scale as well as socio-cultural change taking place in a particular area. The book, finally, contributes to broadening the concept of an immigrant country, especially in the age of global mobility.
Effect of bone anabolic therapy on bone remodeling and bone density in geriatric patients with osteoporosis and falling syndrome
Authors: Khovasova N. O. , Dudinskaya E. N. , Naumov A. V. , Tkacheva O. N. , Machekhina L. V. , Onuchina Ju. S. 
Published: July 2022

BACKGROUND: Older adults with severe osteoporosis are the most vulnerable group of geriatric patients. They are shown the purpose of anti-osteoporotic therapy, which should be effective and safe. Teriparatide showed a decrease in the risk of fractures, an increase in BMD. In Russia, the use of teriparatide in the geriatric population is extremely scarce.AIM: assess clinical course, bone metabolism parameters and efficacy of bone-anabolic therapy in elderly and senile patients with severe osteoporosis and falls.MATERIALS AND METHODS: The longitudinal prospective study included 100 patients 60 years and older with severe osteoporosis who had one or more falls within the last year. All patients were prescribed calcium and vitamin D preparations and bone-anabolic therapy (teriparatide 20 mg daily subcutaneously). The duration of follow-up was 24 months and included 3 visits: screening, at 12 and 24 months. The effectiveness of bone-anabolic therapy was carried out on the basis of assessing the frequency of new fractures, reduction of pain, changes in BMD according to X-ray densitometry, dynamics of bone metabolism markers.RESULTS: All patients had severe osteoporosis and aggravated comorbidity status, suffered a fall within the last year, and also low-energy fractures in the past. One in three patients had a vertebral fracture, one in five had a proximal femoral fracture. Prior to the start of the study, 61 patients received antiosteoporotic therapy. During the follow-up, 4 patients died, 96 patients completed the study. Against the background of teriparatide therapy, a decrease in the number of new cases of low-energy fractures and the number of patients with chronic pain was obtained. An increase in BMD was noted in the lumbar spine after 24 months and in the femoral neck after 12 months. There was no negative dynamics of the BMD. Also after 12 months, an increase in P1NP and C-terminal telopeptide of collagen type 1 was noted, after 24 months — osteocalcin and C-terminal telopeptide.CONCLUSION: The use of teriparatide can be recommended as an effective intervention to treat severe osteoporosis in geriatric patients with falls.
Features of steroidogenesis in men with hypogonadism and type 2 diabetes
Authors: Rozhivanov R. V. , Chernova M. O. , Ioutsi V. A. , Mel’nichenko G. A. , Shestakova M. V. , Mokrysheva N. G. 
Published: July 2022

BACKGROUND: Type 2 diabetes mellitus (DM2) in men is associated with a high incidence of hypogonadism. Testosterone is a steroid hormone and one of the final metabolites of steroidogenesis, which causes interest in assessing the content of key steroid hormones, their precursors and metabolites in hypogonadal and eugonadal men with T2DM.AIMS: Assessment of the features of steroidogenesis in men with hypogonadism in T2DM using tandem mass spectrometry.MATERIALS AND METHODS: A full-design, cross-sectional, screening, single-center, non-interventional study included men with T2DM, who were he was treated in Endocrinology Research Centre, Moscow. The study was conducted from October 2021 to January 2022. Medical history assessment, physical examination with determination of body mass index (BMI), measurement of key steroid hormones, their precursors and metabolites by isotope dilution liquid chromatography/tandem mass spectrometry, glycated hemoglobin (HbA1c) were performed. The groups were compared using the Mann-Whitney U-test for quantitative indicators and χ² with Yates’ correction for qualitative ones. Correlation analysis was performed by the Spearman correlation method. When determining the criterion of statistical significance, the Bonferroni correction was applied.RESULTS: Patients with hypogonadism had statistically significantly more pronounced obesity compared with eugonadal men. In a comparative analysis of patients, depending on the presence of hypogonadism, there were statistically significantly lower levels of androgen precursors 17-hydroxypregnenolone and 17-hydroxyprogesterone in hypogonadal men. At the same time, a positive statistically significant correlation was found between total testosterone and 17-hydroxyprogesterone. In addition, 17-hydroxyprogesterone, although to a lesser extent, but positively correlated with other androgens - androstenedione (r=0,328; p<0,001) and dehydroepiandrosterone (r=0,183; p=0,004). >< 0,001) and dehydroepiandrosterone (r=0,183; p=0,004).CONCLUSIONS: In this investigation the prevalence of male hypogonadism in type 2 diabetes, determined by high-precision tandem mass spectrometry, was 69,5%. There was no effect of the disease on the mineralocorticoid and glucocorticoid links of adrenal steroidogenesis. Hypogonadism was associated with decreased levels of a number of testosterone precursors. The most significant of them was 17-hydroxyprogesterone, which can be considered as a marker of testicular steroidogenesis.
Effect of a new pattern of surface roughness on flow field and erosion rate of a cyclone
Authors: Dehdarinejad Ehsan , Bayareh Morteza 
Published: July 2022

Abstract
This paper evaluates the impact of a special design of non-uniform surface roughness on the operating parameters of a gas–solid cyclone numerically. The cyclone surface is divided into 32 separate rings with different roughness heights when the roughness height varies from 0.2 to 3 mm. The results show that the tangential velocity is reduced and the axial velocity is enhanced by increasing the height of non-uniform roughness. It is observed that the cyclone with smooth walls can collect 7 μm solid particles while 3.7 and 2.77 μm particles can be separated by one-inlet and two-inlet cyclones, respectively. For the cut-off size diameter of d
50, the one-inlet cyclone with smooth walls can collect the particles with a diameter of 1.24 µm, while the cyclone with R
Nu = 0.2, 0.5, 1, 2, and 3 mm can collect 1.3, 1.6, 1.8, 0.83, and 1.88 µm particles, respectively. The results demonstrate that the erosion rate decreases with the roughness and this reduction is larger for the one-inlet cyclone.
Probabilistic analysis of maximum mode shape for mistuned blisk
Authors: Bai Bin , Shi Dongmeng , Xu Zuodong , Liu Xiangdong , Xie Chuxiong , Zhang Wujin , Zhang Xinglong , Wu Xuan 
Published: July 2022

Abstract
The high-fidelity finite element model (HFFEM) and Monte Carlo (MC) simulation of the blisk involve large number of calculations, which leads to low computational efficiency. In this case, an improved quasi-static mode compensation method (IQSMCM) and quadratic function-extremum response surface method (QF-ERSM) are proposed to investigate the probability distribution of mistuned blisk based on its vibration characteristics. The number of nodes and elements of IQSMCM relative to HFFEM are, respectively, reduced by 79.66 and 80.03%. Thus, the degrees of freedoms (DOFs) of IQSMCM are obviously reduced compared with that of HFFEM, and its computational efficiency is obviously increased. The maximum displacement shape (MDS) is investigated via IQSMCM. The computational efficiency is enhanced in the condition of ensuring the computational accuracy. Based on the investigation of maximum mode shape, the probability analysis is performed via QF-ERSM. The computational accuracy of QF-ERSM is improved by 93.80% compared with that of MC. Furthermore, the computational efficiency of QF-ERSM is higher 57.06% than that of QF-RSM. The sample history, extremum response surface function, sample history and distribution histogram of MDS are obtained via QF-ERSM, which provides an important guidance for the reliability research of the mistuned blisk. This research can be applied not only to aeroengine’s blisk but also to other large and complex mechanical structures in practical engineering.
Impact of the COVID-19 pandemic on graduating dental interns: the students’ perspective
Authors: Kumar Mathangi , Madi Medhini , Vineetha Ravindranath , Pentapati Kalyana C 
Published: July 2022

Background. COVID 19 pandemic has caused an unprecedented change in the way of life of the individual as well as of the society globally. Medical and healthcare education has become virtual, complex, and challenging with minimal real-time experience. Dental education has faced major impacts affecting the skills and preparedness of the graduates. This study aimed to assess the overall impact of the COVID 19 pandemic on graduating dental interns.
Methods. This cross-sectional survey was conducted among the graduating dental interns from various states across India. A specially designed questionnaire was used in our study which consisted of multiple-choice, Likert scale, dichotomous response, open-ended response questions. The 15 item questionnaire focused on 5 domains (i) demographic details (ii) perceptions regarding disrupted academic schedule and switch to E-education (iii) perceptions on its impact on the career (iv) items concerning the mental health and stress (v) potential solutions suggested by the interns.
Results. 316 dental interns responded to this survey. Only 13.6% of them felt that the e-platforms were useful tools for learning. The dental interns felt that Conservative Dentistry and Oral Surgery postings had the maximum impact on clinical skills. Less than one-fourth (23.1%) of them agreed with the fact that they were under parental pressure; 43.4% agreed that the pandemic had affected the confidence and preparedness to start their clinical practice.
Conclusion. It was observed that the interns faced major challenges due to the missed hours of clinical practice, which affected them in terms of preparedness and confidence in facing their future.