bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of plasma metabolites associated with modifiable risk factors and biomarkers reflecting Alzheimer’s disease pathology
Authors: Dong Ruocheng , Denier-Fields Diandra N. , Hulle Carol A. Van , Kollmorgen Gwendlyn , Suridjan Ivonne , Wild Norbert , Lu Qiongshi , Anderson Rozalyn M. , Zetterberg Henrik , Blennow Kaj , Carlsson Cynthia M. , Johnson Sterling C. , Engelman Corinne D. 
Published: June 2022

Abstract
Background:
Modifiable factors can influence the risk for Alzheimer’s disease (AD) and serve as targets for intervention; however, the biological mechanisms linking these factors to AD are unknown. This study aims to identify plasma metabolites associated with modifiable factors for AD, including MIND diet, physical activity, smoking, and caffeine intake, and test their association with AD endophenotypes to identify their potential roles in pathophysiological mechanisms.
Methods:
The association between each of the 757 plasma metabolites and four modifiable factors was tested in the Wisconsin Registry for Alzheimer’s Prevention cohort of initially cognitively unimpaired, asymptomatic middle-aged adults. After Bonferroni correction, the significant plasma metabolites were tested for association with each of the AD endophenotypes, including twelve cerebrospinal fluid (CSF) biomarkers, reflecting key AD pathophysiologies, and four cognitive composite scores. Finally, causal mediation analyses were conducted to evaluate possible mediation effects. Analyses were performed using linear mixed-effects regression.
Results:
A total of 27, 3, 23, and 24 metabolites were associated with MIND diet, physical activity, smoking, and caffeine intake, respectively. Potential mediation effects include beta-cryptoxanthin in the association between MIND diet and Preclinical Alzheimer Cognitive Composite score, hippurate between MIND diet and Immediate Learning, glutamate between physical activity and CSF neurofilament light, and beta-cryptoxanthin between smoking and Immediate Learning.
Conclusion:
Our study identified several plasma metabolites that are associated with modifiable factors. These metabolites can be employed as biomarkers for tracking these factors, and they provide a potential biological pathway of how modifiable factors influence the human body and AD risk.
Simulation and Experimental Study on the Incompatibility Issue between ADN and Isocyanate
Authors: sheibani nasser 
Published: June 2022

Abstract
Since solid composite propellants are composed of a high percentage of oxidizers, the search for green oxidizers such as ammonium dinitramide (ADN) as a substitute for non-eco-friendly ammonium perchlorate (AP) is an important issue. ADN/GAP propellants are good green candidates to replace conventional AP/HTPB propellants. The incompatibility issue of ADN with isocyanate curing agents is a well-known problem. In this research, from the perspective of molecular dynamics and solubility parameter concept, an attempt was made to select a suitable curing system for ADN/GAP composite propellants by examining the interaction energy between different isocyanate curing agents and ADN as well as GAP. The examined isocyanates include N100, IPDI, TDI, DDI, IPDI/N100, and DDI/N100. The interaction of the selected curing system with ADN was investigated using infrared spectroscopy at different time intervals and compared with the N100 as a conventional curing system. The results show significant improvement of the selected curing system.
Continuous and simultaneous conversion of Moroccan phosphogypsum waste to Na2SO4, and K2SO4 using the quaternary system Na+, K+ // Cl-, SO42- - H2O at 25°C
Authors: Laaboubi Khaoula , Bouargane Brahim , Moreno Silvia Pérez , Bakiz Bahcine , Raya Juan Pedro Bolívar , ATBIR Ali 
Published: June 2022

Abstract
In this present work, the transformation of the Moroccan phosphogypsum (PG) waste, considered as a potential source of sulfate, into potassium sulfate compound could help to reduce environmental impact and to create a new value chain for the phosphate industry. Generally, solidliquid equilibria are frequently applied in chemical industries. They are a valuable aid for visualizing the precipitation, separation, purification of a solid phase and pathways through which crystallization can proceed. The aim of this process is to produce potassium sulfate, a high-value fertilizer, from sulfate solutions obtained after dissolving Moroccan phosphogypsum in NaOH medium. The quaternary phase diagram Na + , K + // Cl - , SO 4 2- - H 2 O at 25°C was especially used to determine the operating conditions and the design of a crystallization process during the phosphogypsum conversion into potassium sulfate. The Jänecke representation of this system enables the determination of the optimal trajectory in the phase diagram for the double decomposition reaction. X-ray Fluorescent (XRF) and X-ray diffraction (XRD) techniques were conducted to identify the crystalline phases formed. The results of this study could be contributing to the development of a sustainable valorization of Moroccan phosphogypsum. Furthermore, the potassium sulfate represents a good alternative to potassium chloride for chloride-sensitive crops.
Spatiotemporal characteristics of clear-air turbulence (CAT) potential over East Asia during 1979-2020
Authors: Hu Boyan , Hui Pinhong , Ding Jinfeng , Sun Xuguang , Tang Jianping 
Published: June 2022

Abstract
Air turbulence, especially the clear-air turbulence (CAT), always affects flight safety. Based on six CAT diagnostics and ERA5 reanalysis data, the spatiotemporal characteristics of CAT potential in the middle and upper troposphere over East Asia during 1979–2020 and the possible mechanisms are analyzed in this study. The results show that CAT occurs the most frequently in winter and spring at 250–300 and 200–225 hPa, respectively. In general, CAT occurs relatively less in summer and autumn. Besides, the CAT potential decreases with altitude in each season, and the high-magnitude centers gradually move northward and eastward accompanied with a rising motion from winter to summer. During 1979–2020, the CAT potential shows clear increasing trends over most East Asia in winter, while decreasing trends in most regions in summer. In the “high CAT frequency region (HCFR, 75–135°E, 25–45°N) ”, the CAT potential has been significantly increasing in winter and decreasing in summer. Mechanism analysis indicates that the spatiotemporal distribution of East Asian subtropical westerly jet is well correlated with the CAT potential in the HCFR, with the spatial (temporal) correlation coefficients greater than 0.75 (0.54). In addition, the geopotential height pattern in various regions, the zonal circulation in Eurasia and Atlantic, the Polar Vortex, the Subtropical High, and SST all have significant impact on the CAT in the HCFR.
A novel hollow microsphere composite MnOx/PAA: effective catalyst for ozone decomposition at high humidity
Authors: Liu Wei , Zhang Jingwen , Dai Zhao , Luo Ning , Qu Jing , Sun Peiyun , Li Da , Liao Weilong , Wei Junfu , Zhang Huan 
Published: June 2022

Abstract
Air pollution caused by ozone poses a serious threat to human health and ecological environment. Manganese oxide (MnOx) is a popular material for ozone decomposition with excellent catalytic performance. However, under high humidity conditions, water vapor may occupy the oxygen vacancy of manganese oxide, resulting in reduction of the catalytic activity. In this paper, a new type of poly (acrylic acid-co-divinylbenzene) (PAA) hollow microspheres was successfully prepared by distillation precipitation polymerization and HF etching. Then the manganese oxide (MnOx) nanoparticles were loaded on the PAA layer by in-situ synthesis to prepare a MnOx/PAA hollow microsphere catalyst, which greatly improved the catalytic decomposition efficiency of MnOx on ozone under high humidity. The morphology, structure and properties of the catalysts were characterized by TEM, FTIR, XRD, XPS, BET, TGA and contact Angle, respectively. Meanwhile, we also studied the performance of the catalyst for different feeding amount of crosslinking agent and functional monomer, for the cases with or without methanol as the reducing agent and for the effect of hollow structure. It was showed that PAA-60-MnOx-M catalyst with methanol reduction and 60% acrylic acid (AA) content exhibited the best catalytic decomposition performance for ozone. At 50% humidity, the decomposition efficiency of 20 ppm ozone could reach 94.5% within 360 min; while at 90% humidity, the ozone decomposition efficiency could still keep at 85%. Therefore, in the field of air pollution control, this hollow microsphere catalyst has great potential in solving the problem of ozone pollution.
A new species of Trichobius (Diptera: Streblidae) from Mexico and new record of Paratrichobius americanus
Authors: Tlapaya-Romero L. , García-Méndez A. , Ramírez-Martínez M. M. 
Published: June 2022

Abstract
A new species of Trichobius Gervais, 1844 (Diptera: Streblidae) is described from specimens in Jalisco, Mexico, from host bat Choeronycteris mexicana Tschudi. We consider the new species described is related to the “dugesii” group, since it shares certain characteristics those of T. angulatus and T. tiptoni, but it results easy to differentiate from all the known species due to the cheatotaxis of the thorax in which the prescutum setae, and the lateral setae are very long, while the discal setae are abruptly smaller and denser. It also presents the metasternal lobe, which is very broad and translucent.
Isolation, Screening and Characterisation of Bacillus paramycoides for producing Cellulases, Proteases and Amylases from Fabric Industry
Authors: Sarwan Jyoti , k jagadeesh chandra bose 
Published: June 2022

Abstract
There is availability of numerous of microorganisms with their broad applications in environment and removal of contaminants. World is full of microbes that can produce various enzymes at a time. Bacillus is one of the major species among them. Plant fibres contain complex cellulose and amylopectin and pectin in their structures. For breakdown of these complex molecules like cellulose, amylopectin in simpler molecules like hemicellulose and glucose the enzyme required called cellulases with hydrolytic reactions. Article is based upon isolation, screening, identification and crude enzyme production of isolates from fabric industry.
On the modern deep learning approaches for precipitation downscaling
Authors: Kumar Bipin , Atey Kaustubh , Singh Bhupendra Bahadur , Chattopadhyaya Rajib , Acharya Nachiketa , Singh Manmeet , Nanjundiah Ravi , Rao Suryachandra 
Published: June 2022

Abstract
Deep Learning (DL) based downscaling has become a popular tool in earth sciences recently. Increasingly, different DL approaches are being adopted to downscale coarser precipitation data and generate more accurate and reliable estimates at local (~ few km or even smaller) scales. Despite several studies adopting dynamical or statistical downscaling of precipitation, the accuracy is limited by the availability of ground truth. A key challenge to gauge the accuracy of such methods is to compare the downscaled data to point-scale observations which are often unavailable at such small scales. In this work, we carry out the DL-based downscaling to estimate the local precipitation data from the India Meteorological Department (IMD), which was created by approximating the value from station location to a grid point. To test the efficacy of different DL approaches, we apply four different methods of downscaling and evaluate their performance. The considered approaches are (i) Deep Statistical Downscaling (DeepSD), augmented Convolutional Long Short Term Memory (ConvLSTM), fully convolutional network (U-NET), and Super-Resolution Generative Adversarial Network (SR-GAN). A custom VGG network, used in the SR-GAN, is developed in this work using precipitation data. The results indicate that SR-GAN is the best method for precipitation data downscaling. The downscaled data is validated with precipitation values at IMD station. This DL method offers a promising alternative to statistical downscaling.
Isolation, characterization and whole genome analysis of a novel Escherichia phage Tequintavirus GN06
Authors: Wang Leping , Dong Qinting , Tan Yizhou , Liao Yuying , Li Lei , Han Kaiou , Bai Huili , Cao Yajie , Zhou Yuqing , Ma Dongxin , Gong Yu , Wang Xiaoye , Peng Hao 
Published: June 2022

Abstract
Escherichia coli O114:K90(B) is a kind of enteropathogenic E. coli (EPEC). It can cause severe diarrhea and even septicemia in Aquaculture. With the incidence of antibiotic resistance reaching crisis point, it is important to find alternative treatments for multidrug-resistant infections. Using phages for pathogen control is a promising treatment option to combat bacterial resistance. In this study, a lytic phage, named as GN06, was isolated from sewage. It can efficiently lytic E. coli O114:K90(B). Transmission electron microscopy showed that the phage belongs to the Siphoviridae. Phage GN06 has a linear, double-stranded DNA genome of 107,237 bp with a GC content of 39.2% and 155 coding sequences. Cages belonging to the genus Tequintavirus and could be classified as a T5-like virus. BLASTn analysis revealed that phage GN06 shares 94.07% identity (88% genome coverage) with an unpublished Escherichia phage vB_EcoS_HASG4. Moreover, the highest average nucleotide identity (ANI) values of phage GN06 with all the known phages was 0. 83, suggesting that GN06 was a relatively novel phage. Temperature and pH stability tests showed that phage GN06 was stable from 4℃ to 60℃and pH range from 5 to 9. These results suggested that phage GN06 with unique genomic features and high tolerances of pH and temperature had the potential of controlling bacteria pathogens. Therefore, GN06 has the potential to serve as a novel candidate for phage therapy.
Experimental and computational study of salt-containing aqueous two-phase system for extraction of analgesic drugs
Authors: Ghaffari Fariba , Khorsandi Mohammad , Shekaari Hemayat , Zafarani-Moattar Mohammed Taghi 
Published: June 2022

Abstract
In recent decades, aqueous two-phase systems have gained a lot of attention for extraction of different materials. In this work, an aqueous two phase system was made by poly (ethylene) glycol 600 and potassium hydroxide and phase diagram were determined for this system. The experimental binodal data were described using two empirical nonlinear three parameter expressions developed by Merchuk and Zafarani-Moattar. The consistency of the experimental tie-line data was determined by utilizing the Othmer-Tobias, Bancraft, and Setschenow correlations. Also, the extraction of two analgesic drugs, namely ibuprofen and acetaminophen were investigated by the mentioned ATPs. For this purpose, partition coefficients and extraction efficiencies of each drug were calculated. The trend of extraction efficiencies indicated that the responsibility of extraction of the mentioned drugs into the polymer-rich top phase is related to their hydrophobicity. The Diamond-Hsu equation and its modified version were used to correlate the drugs experimental partition coefficients. Furthermore, the interaction of mentioned drugs with polyethylene glycol was investigated employing quantum computing techniques based upon density functional theory (DFT). These results were in good agreement with the trend of extraction efficiencies of studied drugs.
mucosal-associated invariant T cells predict increased acute graft-versus-host-disease incidence in patients receiving allogeneic hematopoietic stem cell transplantation.
Authors: Wang Zhao , Zhang Sudong , zhang Xiaoyu , Liu Li , Zhou Lukun , Shen Yuyan , Zhang Rongli , He Yi , Yang Donglin , Jiang Erlie , Feng Xiaoming , Zhou Jiaxi , Cheng Tao , Han Mingzhe , Feng Sizhou 
Published: June 2022

Abstract
Background:
Mucosal-associated invariant T (MAIT) cells are innate-like T cells, some studies have reported that the number of circulating MAIT cells reduced in patients with acute graft-versus-host-disease (aGVHD) development. However, the role of donor MAIT cells on aGVHD development and subsequent functional change still remain unclear.
Methods:
The study recruited 86 patients with hematological malignancies who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) from May 1, 2018 to June 30, 2019. MAIT cells, their subset, and cytokine levels were measured by flow cytometry. Gray’s test was used to assess the impact of graft MAIT cell proportion and number on aGVHD incidence. The Cox proportional hazard model was used in the multivariate analysis. The comparison for continuous variables was assessed using Mann–Whitney analysis. RNA-sequencing was performed to investigate the possible molecular pathway changes.
Results:
Our study showed that the proportion of MAIT cells in grafts was not different from normal controls, but the CD4/8 subsets were altered. Taking the median of the proportion and number of MAIT cells in the graft as the threshold, the results showed that the incidence of grade B-D aGVHD in patients with MAIT cell proportion ≥ 3.03% was significantly higher than that in patients with MAIT cell proportion < 3.03%.The number of MAIT cells in the graft was not associated with aGVHD development, however, when the graft contained more CD4 positive, CD8 positive, and CD4/CD8 double-positive MAIT cells, the incidence of aGVHD was significantly increased. Besides, reduced frequencies and counts of circulating MAIT cells were observed in patients with aGVHD when compared to patients without aGVHD, accompanied by enhanced production of Tumor necrosis factor-α, Interferon-γ and upregulated programmed death-1, CXC Chemokine Receptor-6 (CXCR6) and CD38 expression. Gene set enrichment analysis of MAIT cell RNA-seq data showed interferon-α response pathway upregulated in aGVHD patients when compared with patients without aGVHD and healthy controls.
Conclusions:
Our study shows that MAIT cells in grafts and peripheral blood are both closely related to the aGVHD development post allo-HSCT. Interferon-α response pathway perhaps is a critical regulation mechanism for the MAIT cell involvement in aGVHD development.
Peroxisome proliferator-activated receptor-γ doesn’t modify altered electrophysiological properties of the CA1 pyramidal neurons in a rat model of hepatic cirrhosis
Authors: Tahamtan Mahshid , Aghaei Iraj , Shabani Mohammad , Nazari Abbas , Pooladvand Vahid , Razavinasab Moazamehosadat 
Published: June 2022

Abstract
Regarding the low quality of life due to the cognitive complications in patients with hepatic cirrhosis (HC), the goal of this study was to examine the possible neuroprotective effect of pioglitazone (PIO) on electrophysiological alterations in the hippocampus, a major area of cognition, in the experimental model of bile duct ligation (BDL). We used adult male Wistar rats in the present study to perform BDL or sham surgery. Pioglitazone was administered in BDL rats two weeks after the surgery for the next continuous four weeks. The effects of pioglitazone on BDL-induced electrophysiological alterations of the CA1 pyramidal neurons in the hippocampus were evaluated by Whole-cell patch clamp recordings. Our findings demonstrated that chronic administration of PIO could not reverse the electrophysiological changes in the CA1 pyramidal neurons of the hippocampus in BDL rats but could improve the hepatic dysfunction. Together, the results of this study suggest that PIO administration cannot counteract altered intrinsic properties of the hippocampal neurons which has been shown recently as an involved mechanism of the cognitive impairments in hepatic encephalopathy (HE).
Evaluation of potential neuroprotective effects of Vanillin against MPP+/MPTP-induced dysregulation of dopaminergic regulatory mechanisms in SH-SY5Y cells and a mouse model of Parkinson's disease
Authors: Rani Linchi , Ghosh Balaram , Ahmad Mir Hilal , Mondal Amal Chandra 
Published: June 2022

Abstract
Parkinson's disease (PD) is the second most progressive neurodegenerative disease, secondarily to Alzheimer's disease. The pathogenesis of PD is still unknown and drugs available for PD treatment either have side effects or suboptimal efficacy. Flavonoids are potent antioxidants with little toxicity with extended use, suggesting they might hold promising therapeutic potential against PD. Vanillin (Van) is a phenolic compound that has exhibited neuroprotective properties in various neurological disorders, including PD. However, the neuroprotective role of Van in PD and its underlying mechanisms are scarce therefore need more exploration. Here, we evaluated the neuroprotective potential of Van and its associated mechanisms against MPP+/MPTP-induced dopaminergic neuronal loss in differentiated human neuroblastoma (SH-SY5Y) cells and mice model of PD. In the present study, Van treatment significantly increased cell viability, reduced oxidative stress, mitochondrial membrane potential and apoptosis in MPP+-intoxicated SH-SY5Y cells. Moreover, Van significantly attenuated the effects of MPP+ on the tyrosine hydroxylase (TH) protein expression and mRNA expressions of GSK-3β, PARP1, p53, Bcl-2, Bax and Caspase-3 genes in SH-SY5Y cells. Similar to our in vitro results, Van provided significant neuroprotection against MPTP-induced neurobehavioral deficits, oxidative stress, aberrant TH protein expressions and immunoreactivity in SNpc of mice brains. Treatment of Van also prevented MPTP-induced loss of dopaminergic TH-positive neurons in SNpc and TH-fibers projecting to the striatum of mice. Thus, Van exhibited promising neuroprotective properties in the current study against MPP+/MPTP-intoxicated SH-SY5Y cells and mice, indicating its novel therapeutic potential against PD.
A novel puncture approach via point “O” for percutaneous kyphoplasty in patients with L4 or L5 osteoporotic vertebral compression fracture
Authors: Huang Jiahu , Yang Jin , Chen Lanjing , Xu Yinzhi , Wang Song 
Published: June 2022

Abstract
[Objective] This study introduced a novel point “O” puncture approach for percutaneous kyphoplasty (PKP) in patients with L4 or L5 osteoporotic vertebral compression fracture (OVCF), and evaluated its clinical and radiographic outcomes.[Methods] Between September 2019 and December 2020, we compared the clinical and radiographic outcomes of 31 cases (36 vertebrae) of “O” entry point PKP intervention (O-PKP), and 31 cases (37 vertebrae) of transverse the process-pedicle approach PKP intervetion (T-PKP).[Results] All participants completed surgery without serious complications. Only 2 T-PKP patients experienced intervertebral disc space leakage. Compared to the T-PKP patients, the O-PKP patients exhibited less operation and fluoroscopy times (P<0.05), comparable blood loss (P>0.05), improved VAS and ODI scores at the final follow-up (P<0.05), more preferable increase in the vertebral compression ratio (P<0.05), comparable Cobb angle (P＞0.05), comparable anteroposterior bone cement distribution, enhanced bilateral bone cement distribution (P < 0.05), and larger sagittal and transverse angles (P<0.05). [Conclusion] Here, O-PKP was indicated for patients with L4 or L5 OVCF. This puncture approach exhibited significant advantages over the T-PKP not only in terms of pain relief, operation time, and fluoroscopy times, but also in the puncture angle, vertebral reconstruction and symmetric cement distribution.