bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and Efficacy of Early Post-Operative Intravenous Iron Replacement In Patients With HeartMate III Left Ventricular Assist Device
Authors: Vesper Ryan M. , Kemp Lauren , Iyer Prashanth , Granger Katelynn , Doligalski Christina T. , Byku Mirnela , Hollis Ian B. 
Published: September 2022

Background: While guidelines suggest intravenous (IV) iron to improve functional status and quality of life (QoL) in patients with NYHA class II-III heart failure (HF), continuous flow left ventricular assist device (CF-LVAD) recipients were not included in early IV iron studies. Our study compared outcomes between patients who did and did not receive IV iron during the index admission following Abbott HeartMate III™ (HM 3) CF-LVAD placement. Methods: Thirty-three adult patients with a HM3 placed at our institution who received early post-operative IV iron (n = 20) or no IV iron replacement (n = 13) were compared. The co-primary outcomes were mean change in quality of life (by the Minnesota Living with Heart Failure Questionnaire [MLHFQ]) and 6-minute walk distance (6MWD) from baseline to first >90 day clinic follow-up. Results: At first clinic follow-up there was no significant difference between the IV iron and no-IV iron groups in MLHFQ (−27 ± 38 vs −21 ± 41, P = .8822) or 6MWD (360 ± 740 vs 786 ± 722, P = .208). Conclusion: Patients receiving IV iron during index admission following HM3 implantation did not experience an improvement in quality of life or functional capacity when compared to those who did not receive IV iron.
Depressive Symptom Trajectories and Cognition Among Older American Couples: A Dyadic Perspective
Authors: Kong Dexia , Lu Peiyi , Solomon Phyllis , Woo Jean , Shelley Mack 
Published: September 2022

Objectives This study examined whether trajectories of depressive symptoms of one spouse are associated with the other spouse’s memory. Methods Longitudinal data from the Health and Retirement Study (2004–2016) were used ( N = 5690 heterosexual couples). Latent-class growth analysis and structural equation models examined the actor and partner effects of depressive symptom trajectories on memory. Results Four depressive symptom trajectories were identified (i.e., persistently low, increasing, decreasing, and persistently high). Compared to the low trajectory group, the increasing and persistently high trajectories were associated with worse memory for both men and women. While none of the wives’ depressive symptom trajectories was significantly associated with husbands’ memory ( p > .05), husbands’ decreasing trajectory was linked to wives’ better memory (β = 0.498, 95% CI = 0.106, 0.890). Discussion Older adults with increasing and persistently high depressive symptoms may experience worse memory. Psychosocial interventions targeting depressive symptoms among older men may be beneficial to their spouses’ memory.
From volume to value: Improving peri-operative elective pathways through a roadmap from fast-track orthopedic surgery
Authors: Pennestrì Federico , Lega Federico , Banfi Giuseppe 
Published: September 2022

Healthcare institutions face the pressure generated by modern medicine and society, in terms of increasing expectations and financial constraints. Chronic patients need multidisciplinary care pathways to preserve their wellbeing across the entire journey. The orthopaedic community has been particularly receptive in testing solutions to align good clinical outcomes and financial sustainability, given the increase in elective procedures provided among aging populations to alleviate pain and reduce disability. Fast-track (FT) total joint arthroplasty (TJA) and bundled payments (BPs) offer relevant examples both from the clinical and the financial perspective; however, they have not been evaluated in combination yet. The aim of this manuscript is to provide a road map to improve the value of high-volume, multidisciplinary elective procedures, with potential applications in a vast number of surgical specialties, (1) based on an integrated financial budget per episode of care (the BP), (2) building on lessons from a review of the literature on FT TJA. Although clinical outcomes vary from procedure to procedure, the coordination between the single treatments and providers involved across the patient journey; the commitment of patients and relatives; and the systematic adoption of patient-reported outcomes; can add further value for the benefit of patients, healthcare funders and providers, once essential clinical, financial and administrative conditions are guaranteed.
Differences in Hospital, Emergency Room and Outpatient Visits Among Adults With and Without Monoclonal Gammopathy of Undetermined Significance
Authors: Castañeda-Avila Maira A. , Lapane Kate L. , Person Sharina D. , Jesdale Bill M. , Zhou Yanhua , Mazor Kathleen M. , Epstein Mara M. 
Published: September 2022

Introduction This study evaluated the impact of receiving a monoclonal gammopathy of undetermined significance (MGUS) diagnosis on healthcare utilization from patients at a community-based multispecialty provider organization. Methods A cohort of patients with MGUS (n = 429) were matched on sex, age, and length of enrollment to a cohort of patients without MGUS (n = 1286). Healthcare utilization was assessed: 1-12 months before, 1 month before and after, and 1-12 months after diagnosis/index date. Multivariable conditional Poisson models compared change in utilization of each service in patients with and without MGUS. Results During the 2 months around diagnosis/index date, the rates of emergency room, hospital and outpatient visits were higher for patients with MGUS than patients without MGUS. In the year before MGUS diagnosis, the association was still elevated, although attenuated. Conclusion Understanding the care of MGUS patients is important given that multiple myeloma patients with a pre-existing MGUS diagnosis may have a better prognosis.
Impact of single-nucleotide variants and nutritional status on population pharmacokinetics of Doxorubicin, and its effect on cardiotoxicity in children with leukemia
Authors: Gándara-Mireles Jesús Alonso , Lares-Asseff Ismael , Reyes Espinoza Elio Aarón , Fierro Ignacio Villanueva , Castañeda Verónica Loera , Cordova Hurtado Lourdes Patricia , González Carla Díaz , Romero Leslie Patrón , Reyes Horacio Almanza 
Published: September 2022

Purpose  Doxorubicin is an important antineoplastic agent with wide interindividual variability in response to treatment and in its cardiotoxic effects. To determine the effect of genotypic status of three single-nucleotide variants in ABCC1, NCF4, and CBR3 genes and nutritional status assessed by body mass index, on the population pharmacokinetics of Doxorubicin and its cardiotoxic effects in pediatric patients with leukemia. Patients and methods Seventy pediatric patients treated with Doxorubicin were studied, in which 189 biological samples were obtained to determine Doxorubicin concentrations (1 to 3 samples per patient) at different times, for 20 h. Results Low body mass index and age ≤ 7 years were associated with decreased clearance of Doxorubicin, and female gender was associated with increased clearance of Doxorubicin. Low BMI and low height were associated with a decrease and increase, respectively, in the intercompartmental clearance (Q) of Doxorubicin. TT homozygosity of the single-nucleotide variant rs3743527 of the ABCC1 gene was associated with an increase in clearance and decreased area under the curve, AA homozygosity of the single-nucleotide variant rs1883112 of the NCF4 gene was associated with a decrease in the volume of distribution in the peripheral compartment (V2), and GG homozygosity of CBR3 rs1056892 with increasing area under the curve. Conclusion Some covariates studied are directly related to the increase or decrease of the pharmacokinetic parameters of Doxorubicin. Decreased clearance, V2, and increased area under the curve were associated with systolic dysfunction, and decreased Q and V2 were associated with diastolic dysfunction. These results may contribute to the effective and safe use of Doxorubicin in pediatric patients with leukemia.
Acetoacetate Improves Memory in Alzheimer’s Mice via Promoting Brain-Derived Neurotrophic Factor and Inhibiting Inflammation
Authors: Wu Xiao-Jun , Shu Qin-Qin , Wang Bin , Dong Lan , Hao Bin 
Published: September 2022

The ketone bodies, especially the β-hydroxybutyrate, had been shown to modulate the function of the central nervous system and prevent the pathological progression of Alzheimer’s disease (AD). However, little is known about the role of acetoacetate in the AD brain. Thus, we intraventricularly injected acetoacetate into familial AD mice (APPSWE) for 14 days and monitored their memory and biochemical changes. During the behavior test, acetoacetate at 100 mg/kg led to significant improvement in both Y-maze and novel object recognition tests (NORTs) (both P < .05), indicating ameliorating spatial and recognition memory, respectively. Biomedical tests revealed two mechanisms were involved. Firstly, acetoacetate inhibited the GPR43-pERK pathway, which led to apparent inhibition in tumor necrosis factor-α and Interleukin-6 expression in the hippocampus in a concentration-dependent manner. Secondarily, acetoacetate stimulated the expression of hippocampal brain-derived neurotrophic factor (BDNF). We concluded that acetoacetate could ameliorate AD symptoms and exhibited promising features as a therapeutic for AD.
Outcome prediction value of critical area perfusion score for acute basilar artery occlusion
Authors: Sun Dapeng , Huo Xiaochuan , Raynald  , Mo Dapeng , Gao Feng , Ma Ning , Albers Gregory W , Miao Zhongrong 
Published: September 2022

Purpose To investigate the performance of the Critical Area Perfusion Score (CAPS), based on computed tomography perfusion (CTP) time to maximum (Tmax) > 10s maps, to predict the outcome in acute basilar artery occlusion (BAO) in patients undergoing endovascular treatment (EVT). Methods We perform a retrospective analysis of a prospectively collected database of acute BAO treated with EVT in a comprehensive stroke center. The favorable outcome was defined as the 90-day modified Rankin Scale (mRS) ≤ 3. We performed the logistic regression analysis to find the independent predictors of the favorable outcome. Then, we used receiver operating characteristic analyses to assess the predictive value of the imaging parameters, including CAPS, Posterior Circulation Alberta Stroke Program Early CT Score (PC-ASPECTS), pons midbrain index (PMI), posterior circulation computed tomography angiography (PC-CTA) score, Basilar Artery on Computed Tomography Angiography (BATMAN) score, and CTP parameters. Finally, the Delong test was used to compare the area under the curve (AUC) of CAPS against the other imaging parameters. Results Of the 65 enrolled patients, the incidence of the favorable outcome was 44.6% (29/65). Low CAPS (per 1- point increased odds ratio [OR], 0.43; 95% confidence interval [CI], 0.22–0.86; P = 0.017) and admission National Institutes of Health Stroke Scale (NIHSS) (per 1- point increased OR, 0.80; 95% CI, 0.70–0.91; P = 0.001) were independently associated with favorable outcome. The AUC of CAPS was 0.83 (95% CI, 0.74–0.93; P < 0.001) with ≤ 3 cut-off value, 89.66% sensitivity, 77.22% specificity, and 80.00% accuracy, which was greater than the other imaging parameters (All P for Delong test < 0.05). Conclusions CAPS was the most accurate imaging-based outcome predictor in acute BAO patients. Future large prospective multicenter studies are needed to verify these results.
Variability in quantifying the Hill-Sachs lesion: A scoping review
Authors: Khan Shahrukh , Shanmugaraj Ajaykumar , Faisal Haseeb , Prada Carlos , Munir Sohaib , Leroux Timothy , Khan Moin 
Published: September 2022

Background Currently, is there no consensus on a widely accepted measurement technique for calculating the Hill-Sachs lesion (HSL). The purpose of this review is to provide an overview of the techniques and imaging modalities to assess the HSL pre-operatively. Methods Four online databases (PubMed, Embase, MEDLINE, and COCHRANE) were searched for literature on the various modalities and measurement techniques used for quantifying HSLs, from data inception to 20 November 2021. The Methodological Index for Non-Randomized Studies tool was used to assess study quality. Results Forty-five studies encompassing 3413 patients were included in this review. MRA and MRI showed the highest sensitivity, specificity, and accuracy values. Intrarater and interrater agreement was shown to be the highest amongst MRA. The most common reference tests for measuring the HSL were arthroscopy, radiography, arthro-CT, and surgical techniques. Conclusion MRA and MRI are reliable imaging modalities with good test diagnostic properties for assessment of HSLs. There is a wide variety of measurement techniques and imaging modalities for HSL assessment, however a lack of comparative studies exists. Thus, it is not possible to comment on the superiority of one technique over another. Future studies comparing imaging modalities and measurement techniques are needed that incorporate a cost-benefit analysis.
Zinner’s syndrome: Triad of seminal vesicle cyst, ejaculatory duct obstruction and ipsilateral renal agenesis: A rare case series
Authors: Deka Hiranya , Thomas Appu 
Published: September 2022

Zinner’s syndrome is a very rare congenital condition characterised by seminal vesicle cyst, obstruction of the ejaculatory duct and ipsilateral renal agenesis. Here, we present a 25-year- old young short-statured male presented with left lower abdominal colicky pain. MRI abdomen showed the absence of the left kidney with a seminal vesicle cyst on the left side. The cyst in question was laparoscopically de-roofed. A second case is a 16-years-old young male who presented with intermittent lower abdominal pain. MRI abdomen showed seminal vesicle cyst with ipsilateral absent kidney which is managed conservatively with medication. Level of evidence: Not applicable
Characteristics of Sciatic Scoliotic List in Lumbar Disc Herniation
Authors: Zhao Yao , Qi Longtao , Ding Chenyuan , Quan Shuo , Xu Beiyu , Yu Zhengrong , Li Chunde 
Published: September 2022

Study Design Retrospective radiological study. Objectives Physical examination reveals sciatic scoliotic list (SSL) in some patients with lumbar disc herniation (LDH). We aimed to evaluate the coronal and sagittal parameters of the SSL curve, describe their characteristics, and establish a new classification system. Methods We retrospectively reviewed 230 patients (SSL group = 96; non-SSL group = 134) diagnosed with single-segment LDH from January 2018 to December 2020. The control group comprised 70 healthy volunteers. Radiographic parameters were compared between the groups. Results In the SSL group, the Cobb’s angle was 12.5 ± 5.3° (4.2-31.2), trunk shift 26.2 ± 17.9 mm (.0-88.2 mm), and apical vertebral translation 31.7 ± 16.0 mm (1.18-8.58 mm). Further, 62.5% of patients had L4/5 disc herniation, 76.0% had disc herniation at the convex side of the lumbosacral scoliosis, and 81.3% had disc herniation at the opposite side of the trunk shift. Compared to the control group, lumbar lordosis and thoracic kyphosis decreased, pelvic tilt increased, and the sagittal vertical axis moved forward in the other patients. The sagittal imbalance in the SSL group exacerbated. Using the positional relationship between vertebrae and the central sacral vertical line (CSVL), we identified two main SSL patterns with which 95.8% of the patients were defined as Type 1. Conclusions The SSL curve is characterized by a long thoracic or thoracolumbar curve, with a relatively straight sagittal profile and little rotation. Further, the lumbar and thoracic vertebrae shifts are on the same side as the CSVL. These features of the SSL curve differentiate it from other types of structural scoliosis.
A Theory of Marketing’s Contribution to Customers’ Perceived Value
Authors: Misra Shekhar , Pedada Kiran , Sinha Ashish 
Published: September 2022

The way customers perceive value is fundamental to business survival and success and is central to marketing theory and practice. Perceived value as an overarching concept describes the contribution of marketing as a key driver in a firm’s success. Though perceived value has gained the attention of academics and practitioners in recent years, the conceptual roots have diverged in different directions. This article synthesizes the concept of customers’ perceive value and presents a theory of marketing’s role in it. This study develops a new theoretical framework of how marketing drives perceived value of customers by reducing and eliminating marketplace imperfections that are always present in oligopolistic markets. This study develops a new theoretical framework of how marketing drives perceived value of customers. We first consider the constituents of customer value—the types of costs and benefits that determine customer’s utility from a purchase, and how marketing can influence these costs and benefits. We then draw upon economics and marketing theories to argue that irrespective of the conceptual lens one adopts, marketing’s primary function is to contribute to perceived value for firms’ customers, which in turn allows marketing to capture value. This article presents four distinct propositions, which articulate how marketing creates value for customers by reducing different types of marketplace imperfections. This article contributes to theory buildings in marketing literature. Laying out theoretical arguments to establish the existence of a marketing-value relationship is critical to validate the relevance and importance of marketing within the firm. The propositions presented in this article can be further used to investigate marketing challenges and questions. From a managerial perspective, it is critical to understand the role of the marketing function in influencing customer value as well. Improved empirical understanding of marketing’s role will enable CEOs to better leverage their firms’ marketing to achieve strategic priorities. Furthermore, by identifying specific marketing activities that create value for customer in different circumstances, managers can more effectively build and leverage their marketing and allocate resources more judiciously. This article synthesizes key developments in the area of customers’ perceived value and presents four novel propositions on marketing’s role in creating customer value.
Eltrombopag in patients with chronic immune thrombocytopenia in Asia-Pacific, the Middle East, and Turkey: final analysis of CITE
Authors: Wong Raymond Siu Ming , Yavaşoğlu İrfan , Yassin Mohamed A. , Tarkun Pınar , Yoon Sung-Soo , Wei Xie , Elghandour Ashraf , Angchaisuksiri Pantep , Ozcan Mehmet , Yang Renchi , Mattar Mervat , Rahman Masiur , Ingles Sara , Goldbrunner Michael , Frueh Jennifer A. , Jang Jun Ho 
Published: September 2022

Abstract
CITE was a prospective, noninterventional study in adult patients with chronic immune thrombocytopenia treated with eltrombopag under routine clinical care in Asia-Pacific, the Middle East, and Turkey. Data to assess eltrombopag usage, compliance, and outcomes were collected from May 2017 to December 2020. Platelet response was defined as platelet count ≥50 × 103/μL in the absence of rescue medications and splenectomy. Quality of life was evaluated using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) questionnaire. Noncompliance was defined as the number of missed doses and number of days where the patient did not follow food instructions. A total of 231 patients were enrolled; the median (range) duration of eltrombopag treatment was 484.5 (1-642) days. Compliance to prescribed eltrombopag dose since the previous routine visit was high at ≥96.0%. Baseline median platelet count was 19.0 × 103/μL, which increased to ≥50 × 103/μL at month 2 and mostly fluctuated between 70 × 103/μL and 100 × 103/μL thereafter. The median time to first platelet response was 1.05 (95% confidence interval: 0.92-1.28) months, and the median (interquartile range) maximum duration of platelet response was 193 (57-456) days. FACIT-F scores improved from a mean (standard deviation) 34.4 (12.1) at baseline to 38.5 (9.1) at month 18. Adverse events occurred in 50.9% of patients (n = 116), the most common being upper respiratory tract infection (8.3%) and headache (6.6%). These findings confirmed the effectiveness of eltrombopag treatment in routine practice and reassured that real-world compliance to eltrombopag-prescribed doses and dietary instructions in Asia-Pacific, the Middle East, and Turkey were in line with current recommendations.
Variants influencing age at diagnosis of HNF1A-MODY
Authors: Ludwig-Słomczyńska Agnieszka H. , Seweryn Michał T. , Radkowski Piotr , Kapusta Przemysław , Machlowska Julita , Pruhova Stepanka , Gasperikova Daniela , Bellanne-Chantelot Christine , Hattersley Andrew , Kandasamy Balamurugan , Letourneau-Freiberg Lisa , Philipson Louis , Doria Alessandro , Wołkow Paweł P. , Małecki Maciej T. , Klupa Tomasz 
Published: September 2022

Abstract
Background
HNF1A-MODY is a monogenic form of diabetes caused by variants in the HNF1A gene. Different HNF1A variants are associated with differences in age of disease onset, but other factors are postulated to influence this trait. Here, we searched for genetic variants influencing age of HNF1A-MODY onset.

Methods
Blood samples from 843 HNF1A-MODY patients from Czech Republic, France, Poland, Slovakia, the UK and the US were collected. A validation set consisted of 121 patients from the US. We conducted a genome-wide association study in 843 HNF1A-MODY patients. Samples were genotyped using Illumina Human Core arrays. The core analysis was performed using the GENESIS package in R statistical software. Kinship coefficients were estimated with the KING and PC-Relate algorithms. In the linear mixed model, we accounted for year of birth, sex, and location of the HNF1A causative variant.

Results
A suggestive association with age of disease onset was observed for rs2305198 (p = 2.09E−07) and rs7079157 (p = 3.96E−06) in the HK1 gene, rs2637248 in the LRMDA gene (p = 2.44E−05), and intergenic variant rs2825115 (p = 2.04E−05). Variant rs2637248 reached nominal significance (p = 0.019), while rs7079157 (p = 0.058) and rs2825115 (p = 0.068) showed suggestive association with age at diabetes onset in the validation set.

Conclusions
rs2637248 in the LRMDA gene is associated with age at diabetes onset in HNF1A-MODY patients.