bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Black Carbon in Ciudad Valles, San Luis Potosí, México, During Sugarcane Harvest 2020-2021
Authors: Pérez-Medina Pedro , Galindo-Mendoza María Guadalupe , Barrera Valter A. 
Published: October 2022

Abstract
This work evaluates Black Carbon emissions produced in Ciudad Valles, San Luis Potosí, México, during the harvest 2020–2021 of Ingenio Plan de Ayala and its association with the sugarcane sector in its area of influence. Black Carbon concentrations were measured each hour by the 7-wavelength aethalometer (AE-33) from November 13, 2020, to June 7, 2021, at Tecnológico Nacional de México - Campus Ciudad Valles, located northeast of the city, approximately 1 kilometer from Ingenio and bordered by the sugarcane area. The maximum daily concentration recorded was 4.5 ± 0.072 µg m− 3 with a daily average of 0.9 ± 0.014 µg m− 3, enough to increase the mortality of the long-term exposed population by almost 6.0% moreover, according to the World Health Organization, and to cause environmental and productive effects. The burning of fossil fuels represented 62.9% of the total Black Carbon, indicating that contrary to official statistics, Ingenio Plan de Ayala may continue using fuel oil. Likewise, there was a statistically significant difference in Black Carbon concentrations during harvest and no harvest periods, indicating a direct relationship between its emissions and the sugarcane sector of this region. The highest concentrations were in the surrounding area of Ingenio Plan de Ayala and sugarcane lands, which supports the previous theory. With the results obtained, the bottom line is that evaluating other agricultural burning emissions near the growing cities is necessary to minimize adverse effects on human health and reduce CO2eq emissions.
Benefit of postoperative chemotherapy in operated gastric or gastro-esophageal junction adenocarcinoma ypT0-3N0 : a retrospective and multicenter AGEO study
Authors: Juin Charlotte , Gallois Claire , Philonenko Sara , Artru Pascal , Trouilloud Isabelle , McLellan Paul , Malet Alice , Coutzac Clelia , Smolenschi Cristina , Dubreuil Olivier , Deutsch David , Baumgaertner Isabelle , Danion Pauline , Rigault Eugenie , Palmieri Lola-Jade , Coriat Romain 
Published: October 2022

Abstract
Background

Standard therapy in gastric or gastro-esophageal junction (GOJ) adenocarcinoma is perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel (FLOT regimen). FLOT offers significant histological response rates. The objective of our study was to evaluate the benefit of postoperative chemotherapy on recurrence free survival (RFS) in operated gastric or gastro-esophageal junction adenocarcinoma ypT0-3N0.

Materials and Methods.

This retrospective mulicenter study included patients with gastric or GOJ adenocarcinoma ypT0-3N0 treated with preoperative FLOT-type chemotherapy and operated between January 2017 and January 2022. Patients were divided into two groups: a group without postoperative chemotherapy (monitoring group) and a group with postoperative chemotherapy (chemotherapy group). Primary criterion was RFS. Secondary criterion was overall survival (OS).

Results

A total of 123 patients were included, 107 in the post chemotherapy group and 16 in the monitoring group. Patients in the chemotherapy group were younger (59 vs. 67 years) and had had less preoperative chemotherapy dose reduction (29 vs. 43,7%). There was no significant difference between the 2 groups concerning RFS (p = 0,87) and OS (p = 0,93).

Conclusion

Our study suggests that postoperative chemotherapy does not improve survival in gastric or GOJ adenocarcinoma following surgery and 4 cycles of preoperative FLOT. Our study paves the way for a prospective randomized trial focusing on the usefulness of 4 cycles of post operative FLOT.
Publication type :
MeSH : Academic Dissertation
Evaluation of Sexual Function Problems in Multiple Sclerosis Patients
Authors: çıracıoğlu ayşe merve 
Published: October 2022

Abstract
Background: Sexual dysfunctions are often observed in Multiple Sclerosis, affecting the quality of life but are frequently ignored. Our study aims to examine the relationship between demographic data, clinical symptoms, functional capacity, and quality of life in patients with MS and sexual dysfunction.
Methods: A total of 51 sexually active MS patients, 28 female and 23 males, were included in the study. Demographic data of all patients were recorded. Questionnaires included Female Sexual Function Index (FSFI) for women's sexual function, the International erectile function form (IIEF)c
for men's sexual function, EDSS for functional capacity, SF-36 for quality of life, and Timed 25 Foot Walk test (T25FW) were applied.
Results: Sexual dysfunction was found in 92.9% of women and 73.9% of men. Decreased sexual arousal, lubrication, and orgasm problems were most common in women, while erectile dysfunction, sexual desire, and sexual satisfaction problems were prominent in men. A significant correlation was found between FSFI and SF-36 in women and IIEF and nine holes, EDSS, and SF-36 in men.
In conclusion: Sexual dysfunction is common in men and women patients with MS and can affect different aspects of the quality of life. Increased awareness is important for appropriate treatment methods and quality of life.
Macrophages/Microglia Sirt3 Contributes to the Anti-inflammatory Effects of Resveratrol against Experimental Intracerebral Hemorrhage in Mice
Authors: Sun Jidong , Pu Chen , Yang ErWan , Zhang Hongchen , Feng Yuan , Luo Peng , Yang Yuefan , Zhang Lei , Li Xia , Jiang Xiaofan , Dai Shuhui 
Published: October 2022

Abstract
Intracerebral hemorrhage (ICH) is a devasting stroke type with high mortality and disability. Inflammatory response induced by macrophages/microglia (M/Ms) activation is one of the leading causes of brain damage after ICH. The anti-inflammatory effects of resveratrol (RSV) have already been evaluated in several models of central nervous system disease. Therefore, we designed the current study to assess the role of RSV in ICH and explore its downstream mechanism related to Sirt3. The autologous artery blood injection was administrated to create an ICH mouse model. M/Ms specific Sirt3 knockout Sirt3f/f; CX3CR1-Cre (Sirt3 cKO) mouse was used to evaluate the role of Sirt3 on RSV treatment. Neuronal function and hematoma volume were assessed to indicate brain damage. The pro-inflammatory marker (CD16) and cytokine (TNF-α) were measured to evaluate the inflammatory effects. Our results showed that RSV treatment alleviates neurological deficits, reduces apoptosis, and increases hematoma clearance on day 7 after ICH. In addition, RSV effectively suppressed CD16+ M/Ms activation and decreased TNF-α release. In Sirt3 cKO mice, the protective effects of RSV were abolished, indicating the potential mechanism of RSV was partially due to Sirt3 signaling activation. Therefore, RSV could be a promising candidate and therapeutic agent for ICH and Sirt3 could be a potential target to inhibit inflammation.
Status, changing landscape and farmer’s criteria for continuity of Paddy (Oryza sativa) landraces in upland ecosystem like Jharkhand, India: from conservation perspective
Authors: Kumari Neetu , Choudhary Shashi Bhushan , Amrapali Shephalika , Jha Basant Kumar , Sharma Hariom Kumar , Kumar Chandra Bhushan , Singh Omkar Nath 
Published: October 2022

Abstract
Present study involved paddy landraces naturalized widely across Jharkhand, India with altitude range from 06 meter from sea level (Sahibganj, Jharkhand, India) to 768 m (Garhwa, Jharkhand, India). These landraces found naturalized to diverse niche areas including flat to slopy upland, lowland, rivulet edge, pond/dam basin, swampy areas with wide altitude, edaphic and landscape ranges. Landraces from iron and aluminum ore (West Singhbhum, Jharkhand, India and East Singhbhum, Jharkhand, India) as well as Mica (Giridih, Jharkhand, India and Koderma, Jharkhand, India) rich regions are potential source for extraordinary mineral tolerance and bioaccumulations. Collection of the maximum paddy landraces from Central North East Plateau (CNEP) sub-zone well supplemented with complementarity analysis. These habitats with ecologically stressful conditions owing to limitations in soil pH, soil texture and other factors considered as a potential site for evolution of unique traditional varieties. However, the resource base found critically eroded from 2005 to 2021 particularly from Ranchi, Hazaribagh, Ramgarh, Chatra, Bokaro, Dhanbad, Koderma, Deoghar and Palamu. The Maximum landrace erosion witnessed in CNEP sub zone. While continued cultivation of landraces in steeper landscape of both South Plateau sub-zone and South Eastern Plateau sub-zone underscored their value in risk aversion under a challenged environmental condition. Selection criteria analysis of continued paddy landraces demonstrated farmers preference for practically useful traits those influencing livelihood security in local context. These traits are key for mainstreaming registered landraces into production chain under changed climatic conditions.
Quaternion MIMO millimeter wave antenna for 5G applications
Authors: Gao Ming-Ming , Wang Jun , Nan Jing-Chang , Niu Hong-Liang 
Published: October 2022

Abstract
In order to reduce the influence of signal attenuation caused by multipath effect in the transmission process of millimeter wave, this paper designs an array MIMO antenna working at 28GHz, the size of the antenna is 26×26×0.254mm3, the central frequency of the antenna is 28GHz, the operating bandwidth is 24 ~ 32GHz, which completely covers the 5G spectrum range of 24.25 ~ 27.5GHz as stipulated by China. The isolation degree between each unit antenna unit port is lower than − 25dB, and the gain of antenna at 28GHz is 7.5dB, which can ensure the normal operation of antenna.
Poly(ε-caprolactone)-based nanofibrous scaffold incorporated with decellularized bone extracellular matrix as a potential strategy for bone regeneration
Authors: Zhang Ming , Zhou Quan , Dong Qiangsheng , Zhang Jue , Zhou Xin , Huang Hao , Bao Junchen , Shan Hongjian , Sun Furong , Li Liangliang 
Published: October 2022

Abstract

Background:Critical size bone defect is still a great challenge in orthopedics. Scaffolds with nanofibrous microstructure seems a promising candidate for critical size bone defect repair. Here we fabricated poly(ε-caprolactone)-based nanofibrous scaffold incorporated with bone derived decellularized extracellular matrix (PCL/dB-ECM) to provide a suitable platform for bone regeneration.Methods:dB-ECM was prepared first and different weight ratios of PCL and dB-ECM was blended to fabricate PCL/dB-ECM nanofibrous scaffolds by electrospinning. The physicochemical properties of the nanofibrous scaffolds were investigated. Rabbit bone mesenchymal stem cells (rBMSCs) were seeded on the nanofibrous scaffolds to evaluate cell proliferation, viability, morphology, cytoskeleton spread and osteogenic differentiation. The ability of the scaffolds to promote bone regeneration in vivo was also assessed by being implanted into a rabbit femoral condyle defect model.Results:The microstructure of the PCL/dB-ECM (2:1) nanofibrous scaffold exhibited randomly arranged nanofibers interlaced to each other to form a network structure. The incorporation of dB-ECM into the scaffold improved the bioactivity of PCL, significantly enhanced the attachment, proliferation and cytoskeleton extension of rBMSCs, as well as remarkably promoted osteogenic differentiation of rBMSCs by elevating the expression of osteogenic-related genes and proteins and by enhancing the ALP activity and calcium deposition. Furthermore, in vivo assays demonstrated that PCL/dB-ECM (2:1) nanofibrous scaffold obviously facilitated new bone formation with better trabecular structures and excellent integration with the surrounding tissues.Conclusion:The PCL/dB-ECM (2:1) nanofibrous scaffold showed excellent bioactivity to facilitate rBMSCs proliferation and osteogenic differentiation in vitro, as well as promoted new bone formation in vivo, suggesting the PCL-based nanofibrous scaffolds incorporated with dB-ECM could be a promising strategy for effective repair of bone defect.
Seismic Vulnerability Assessment of Multi-arch Gallery Masonry Bridges Adopting Different Seismic Analysis Procedures
Authors: Shimpi Vinay , Sivasubramanian Madappa VR , Singh S.B. 
Published: October 2022

AbstractIndia has one of the longest rail networks all over the world. The Indian railway network consist of many heritage bridges which are still in service over span of 100 years. Some of these heritage bridges are located in the very high seismic zone which is threat to their structural integrity. Therefore, it is necessary to assess the performance of these bridges for the earthquake loading. For this purpose, this paper attempts to predict the seismic vulnerability of the two multi arch gallery bridges of UNESCO recognised Kalka Shimla Mountain Railway. In this paper, three dimensional numerical models of the bridges were developed in ABAQUS finite element environment. The macro-modelling strategy was followed along with the concrete damage plasticity model as constitutive model for stone masonry. Further, the seismic performance of the bridges was estimated by nonlinear static analysis and incremental dynamic analysis procedures. The nonlinear static analysis was performed adopting two lateral loading patterns and incremental dynamic analysis was performed using 30 accelerograms. The 30 accelerograms were matched with the site-specific spectra and then scaled to different level of peak ground acceleration. The results from the nonlinear static analysis and incremental dynamic analysis were presented in terms of control node displacement and location of tensile damages. Lastly, the comparison between nonlinear static analysis results and incremental dynamic analysis results were showed that confirms, incremental dynamic analysis results are more significant at very high computational time consumption.
Glutaredoxin-1 modulates the NF-κB signaling pathway to activate inducible nitric oxide synthase in experimental necrotizing enterocolitis
Authors: Zhang Yunfei , Tian Bing , Ding Xin , Zhu Hai , Liu Jian , Hu Yuhui , Guo Chunbao 
Published: October 2022

Abstract
Glutaredoxin-1 (Grx1) is a cytosolic thioltransferase that catalyzes reduction of GSH-protein adducts and plays an important role in pathophysiological of Necrotizing enterocolitis (NEC). The Nuclear factor kappa B (NF-κB) pathway is inhibited by S-glutathionylation of inhibitory kappa B kinase beta (IKKβ), which can be restored by Grx1. Inducible nitric oxide synthase (iNOS) regulated by NF-κB is crucial in the progression of NEC. We aim to explore the role of Grx1 in experimental NEC. Wild-type (WT) and Grx1-knockout (Grx1-/-) mice were treated with a NEC-inducing regimen. The production of iNOS, NO, and inflammation injuries were assessed. NF-κB and involved signaling pathways were also explored. The severity of NEC was attenuated in Grx1-/- mice. Grx1 ablation promoted IKKβ glutathionylation, NF-κB inactivation, and decreased iNOS and NO production in NEC mice. Grx1 ablation protected NEC through iNOS and NO inhibition, which may be related to S-glutathionylation of IKKβ to inhibit NF-κB signaling. Grx1-related signaling pathways maybe provide a new therapeutic target in NEC.
Low-volume Resistance Training: Impact of Load Intensity on Sarcopenia Indicators in Post-menopausal Women Rt Intensity on Sarcopenia Indicators
Authors: Paula¹ Rodolfo F. , Orsatti Fábio Lera , Santos¹ Danilo F. C. dos , Sousa¹ Wellington G. , Souza Markus Vinicius Campos , Margato Luanna Rodrigues , Lino Anderson D. S 
Published: October 2022

Abstract
This study investigated the impact of intensity in a low-volume RT on sarcopenia indicators in postmenopausal women (PTW). Thirty-two participants were randomly assigned to either a control group (CT, n = 10), a LL-RT group (n = 10) that performed one set of 25–30 repetition maximum per exercise or a high-load RT group (HI-RT, n = 12) that performed one set of 8–12 repetition maximum per exercise. The RT groups performed 8 exercises, with 90 seconds of rest between exercises, 2 times a week for 24-weeks. Muscle mass (MM) of limbs (upper and lower) was assessed by DEXA, muscle strength (MS) was measured by the 1-RM leg press test, and physical performance by the TUG test and the 30-second sit to stand test. The ANCOVA (covariates: age, antihypertensive drugs, hormone replacement therapy and pre-time values) was used to analyze the gains (Δ) between groups, with a significance level of 5%. After 24-weeks of RT, lower and upper limb MM (together/summed) increased in both HI-RT (Δ = 0.60 kg; 95% CI: 0.23–1.0 kg) and LI-RT (Δ = 0.48 kg; 95% CI: 0.06–0.91 kg) in relation to CT (Δ=-0.03 kg; 95% CI: -0.43–0.37 kg) with no difference between them (p = 0.016; ƞ²=0.27 (large); observed power = 0.83). However, upper limb MM increased only in the HI-RT. For MS, the HI-RT group (Δ = 40 kg; 95% CI: 21–58 kg) showed greater gains compared to the CT (Δ = -5 kg; CI 95%: -24–14 kg) and LL (Δ = 12 kg; 95% CI: -8–33 kg) (p = 0.001 η2 = 0.35, Power = 0.98). Even though LI-RT promotes MM gains in lower limbs, HI-RT should be considered in low-volume training to promote gains in MS and also in MM in upper limbs in the PTW.
The impact of different targeted temperatures on out of hospital cardiac arrest outcomes in patients receiving extracorporeal membrane oxygenation: a nation-wide cohort study
Authors: Watanabe Makoto , Matsuyama Tasuku , Miyamoto Yuki , Kitamura Tetsuhisa , Komukai Sho , Ohta Bon 
Published: October 2022

Abstract
Background:Targeted temperature management (TTM) is recommended in the management of out-of-hospital cardiac arrest (OHCA) when coma persists after the return of spontaneous circulation. In the setting of extracorporeal membrane oxygenation (ECMO) for OHCA patients, TTM is associated with good neurological outcomes and recommended in the Extracorporeal Life Support Organization guidelines.However, the optimal targeted temperature for these patients has not yet been adequately investigated. This study aimed to compare the impact of different targeted temperatures on the outcomes in OHCA patients receiving ECMO.
Methods:This was a retrospective analysis of data from the Japanese Association for Acute Medicine (JAAM)-OHCA Registry, a multicentre nationwide prospective database in Japan in which 103 institutions providing emergency care participated.OHCA patients aged ≥ 18 years who required ECMO with TTM between June 2014 and December 2019 were included in our analysis. The primary outcome was 30-day survival with favourable neurological outcomes, defined as a Glasgow-Pittsburgh cerebral performance category score of 1 or 2. Patients were divided into two groups according to their targeted temperature: normothermic-TTM (n-TTM) (35–36 ℃) and hypothermic-TTM (h-TTM) (32–34℃). We compared the outcomes between the two targeted temperature groups using multivariable logistic regression and propensity score analyses with inverse probability weighting.
Results: A total of 890 adult OHCA patients who received ECMO and TTM were eligible for our analysis. Of these patients, 249 (28%) and 641 (72%) were treated with n-TTM and h-TTM, respectively. The proportions of patients with 30-day favourable neurological outcomes were 16.5% (41/249) and 15.9% (102/641), in the n-TTM and h-TTM groups, respectively. No difference in neurological outcomes was observed in the multiple regression analysis [adjusted odds ratio 0.91, 95% confidence interval (CI) 0.58–1.43], and the result was constant in the propensity score analysis (odds ratio 1.01, 95% CI 0.67–1.54).
Conclusion:No difference was observed between n-TTM and h-TTM in OHCA patients receiving TTM with ECMO. The current understanding that changes to the targeted temperature have little impact on the outcome of patients may remain true regardless of ECMO use.
A battery-free, chipless, soft nanofluidic intracellular delivery patch for internal organs
Authors: Yu Cunjiang , Li Mo , Chang Lingqian , Yu Xinge , Yin Dedong , Wang Pan , Hao Yongcun , Yue Wei , Yao Kuanming , Wang Yuqiong , Zhou Jingkun , Wu Meng , Jiang Xinran , Wu Han , Lin Long , Zhang Qingyang , Dong Zaizai , Rao Zhoulyu , Xu Chenjie , Chang Honglong , Fan Yubo 
Published: October 2022

Abstract
Internal organ targeted delivery to enable gene editing and induced apoptosis among others, holds tremendous promise in treating numerous challenging diseases. The current and dominant method is circulation-based delivery; yet it has critical limitations on the efficiency, safety, and/or controllability. Here, we report a battery-free, chipless, soft nanofluidic intracellular delivery (NanoFLUID) patch that is capable of enhanced, customized delivery in targeted internal organs. The chipless architecture and the flexible nature of thin functional layers ensure seamless integration with internal organs. The unique nanopore-microchannel-microelectrode structure renders unprecedented features of safe, efficient, precise electro-perforation of cell membrane and of accelerated intracellular payload transport by 104 – 105 times compared with conventional diffusion methods, while operating under relatively low amplitude pulses (20V or less). It was demonstrated that the NanoFLUID patch could achieve customized delivery into mammary gland of adult mice for gene editing to construct both primary and metastatic breast tumor models. The patch showed high efficiency for transfecting a gene pool of more than 40 genes in cells within a targeted organ. It was further demonstrated that the NanoFLUID patch based three-time iterative delivery of a cancer inhibitor (PARPi) could achieved similar breast tumor inhibition as that from daily oral administration for three weeks.
An Extensive Analysis Between Different Language Models: GPT-3, BERT and MACAW
Authors: Gaikwad Arya , Rambhia Palash , Pawar Sarthak 
Published: October 2022

Abstract
The increase in human interactions with commercial applications has given rise to the demand for Interactive interfaces like chat- bots, text translators, text predictors, and text generators which use pre-trained Language Models to perform their own specific tasks. Language models are leading-edge technologies that enable machines to read, decode, comprehend, and make sense of human languages and respond in appropriate ways. In this paper GPT-3, BERT and Macaw language models are tested on different categorial questions to understand their architecture and behaviour in various circumstances. GPT-3 being pre-trained on a robust dataset gives very elaborate and human like answers, while the outputs produced by BERT can be customised by providing custom context and on the other hand Macaw shows more accuracy while answering to general questions.
Exploratory analysis of South America wines using artificial intelligence
Authors: Carneiro Candice N. , Gomez Federico J. V. , Spisso Adrian , Silva Maria Fernanda , Santos Jorge L. O. , Dias Fabio S. 
Published: October 2022

Abstract
The microwave-induced plasma optical emission spectrometer has been used for multielement determination in South American wine samples. The analytes were determined after acid digestion of 47 samples of Brazilian and Argentine wine and the application of logistic regression, support vector machine, and decision tree for exploratory analysis and the comparison of these algorithms in differentiating red wine samples by region of origin. The Brazilian wines samples were clustering in a group, while Argentines wines samples formed another cluster. The quantification limits (mg L-1) were P (0.06); B (0.08); K (0.17); Mn (0.002); Cr (0.002) and Al (0.02). The accuracy of the method was evaluated analyzing the wine samples by ICP OES for results comparison. The concentration in mg L-1 found for each element in wine samples, were Al (< 0.02 - 1.82), Cr (0.15 - 0.50), Mn (< 0.002 - 0.8), P (97 - 277), B (1.7 - 11.6), Pb (< 0.06 - 0.3), Na (8.84 - 41.57) and K (604 - 1701), in mg L-1.