bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous complete uterine rupture with protrusion of foetal limbs at the third trimester following laparoscopic cornuostomy
Authors: Feng Jianyang , Kang Yahui , Chen Guixian , Zhang Yaoyue , Li Yuan , Li Yi , He Hong 
Published: February 2022

Abstract

Rationale:
Spontaneous complete uterine rupture during gestation is rare and has no specific symptoms; however, it is a life-threatening event for both the fetus and mother. The rupture typically happens in labor and is uncommon before labor. Herein, we present the case of a woman, encountering complete rupture at third trimester followed by laparoscopic cornuostomy.

Patient concerns:
A 26-year-old woman presented with acute right lower abdominal pain at 33 weeks and 5 days of gestation.

Diagnoses:
We made a diagnosis of threatened uterine rupture.

Intervention:
Urgent cesarean section performed. Exploration of the uterine dehiscence wound demonstrated that the myometrium was completely ruptured at the primary laparoscopic surgical scar with a defect of 40 mm, and live birth and preservation of the uterus was achieved.

Outcome:
On the third day of operation, she had a good recovery and was discharged. After a 6-week postpartum follow-up, she displayed a good level of rehabilitation.

Lessons:
Pregnancy after laparoscopic cornuostomy should be treated as high-risk gestation and the rupture during gestation of the uterine scar should be suspected once lower abdominal pain occurred. Swift diagnosis and prompt intervention play a crucial role in saving the lives of the fetus and the mother.
Association between IL8RB C1208T mutation and risk of cancer
Authors: Sun He-Yun , Min Zhi-Chao , Gao Lei , Zhang Zi-Yi , Pang Ting-Le , Gao Ying-Jun , Pan Hong , Ou-Yang Jun 
Published: February 2022

Abstract

Introduction:
The CXC chemokines are unique cytokines that play a vital role in the progression of many cancers. Association between chemokine (C-X-C motif) receptor 2 (IL8RB) C1208T mutation and cancer risk remains incomprehensive.

Methods:
We therefore utilized odds ratios and in silico analysis to explore the relationship of IL8RB polymorphism on risk to cancer. Furthermore, we adopted gene set enrichment analysis to investigate the IL8RB expression in prostate adenocarcinoma.

Results:
A total of 14 case-control studies combined with 5299 cases and 6899 controls were included in our analysis. We revealed that individuals carrying TT genotype had an 14% increased cancer risk compared with those with TC + colon cancer (CC) genotype (odds ratio [OR] = 1.14, 95% CI = 1.05–1.25, P = .003, I
2 = 35.6). Stratification analysis by race showed that East Asians with TT + TC genotype may have a 25% decreased cancer risk compared with control. Stratification analysis by cancer type revealed that individuals with TT genotype were associated with elevated risk of urinary cancer than control. The expression of IL8RB was attenuated in prostate adenocarcinoma.

Conclusions:

IL8RB C1208T may be correlated with the risk of cancer, especially prostate adenocarcinoma.
Effects of compound Danshen dropping pills on adverse cardiovascular events and quality of life after percutaneous coronary intervention in patients with coronary heart disease
Authors: Lv Lina , Yuan Xianying , Jiang Lihong 
Published: February 2022

Abstract

Background:
Percutaneous coronary intervention (PCI) is an important means for the treatment of coronary atherosclerotic heart disease and has effectively reduced the mortality of coronary heart disease. However, reperfusion can also cause certain damage to the vascular endothelium, leading to the major adverse cardiovascular events. Compound Danshen dropping pill is a Chinese patent medicine preparation. At present, many studies have evaluated the effect of compound Danshen dropping pill in reducing the incidence of adverse cardiovascular events after PCI. This study systematically evaluated the effect of compound Danshen dropping pills on major adverse cardiovascular events and quality of life after PCI and provides a reference for clinical application and research.

Methods:
All randomized controlled trials on the effects of compound Danshen dropping pills on adverse cardiovascular events and quality of life after PCI for coronary heart disease were searched for. The search was conducted from database inception to January 2022. Data extraction and quality assessment were performed by 2 reviewers according to the Protocol Guidelines for Systematic Reviews and Meta-analyses Protocols statement guidelines. Meta-analysis was performed using Review Manager Version 5.4 software and Stata 16 software.

Results:
The results of this study will allow for systematically evaluation of the effects of compound Danshen dropping pills on adverse cardiovascular events and quality of life after PCI for coronary heart disease.

Conclusion:
This study will provide objective evidence of a basis for compound Danshen dropping pills reducing adverse cardiovascular events and improving quality of life after PCI.
Retrospective analysis of ten cases of transabdominal follicular aspiration for Oocytes retrieval and cryopreservation in patients with malignant diseases
Authors: Abduljabbar Hassan , Hashim H. , Abduljabar Hanin , Gehad M. , Sabban Husain , Qora Ghada , Rund Nancy Mohamed Ali 
Published: February 2022

Abstract

Introduction:
Oocyte cryopreservation is used to preserve a woman's oocytes. It is a technique that enables females to postpone pregnancy to a later date, for reasons such as medical (cancer treatment) or in some countries for social reasons such as employment or study.

Patient concerns and diagnoses:
Cryopreservation of oocytes in ten young, single, and virgin women with malignant disease

Interventions:
Transabdominal follicular aspiration for oocyte retrieval and cryopreservation

Outcome:
A total of 148 oocytes were retrieved. The number of mature oocytes retrieved were 112. The operative time ranged from 45 minutes to 120 minutes. None of the patients had complications after the procedure.

Conclusion:
Transabdominal ultrasound-guided aspiration can be the modality of choice for women with malignant disease, especially unmarried/ virgin women who desire to retain intact hymen for cultural reasons.
Huge perianal basal cell carcinoma
Authors: Gan Zhi-ming , Xu Jian-hua , Zhang Chao , Luo Ya 
Published: February 2022

Abstract

Introduction:
Basal cell carcinoma (BCC) is a common skin malignancy, but perianal BCC is rare and usually small. Here, we present a patient with a condyloma-like huge perianal BCC.

Patient concerns:
A 60-year-old Chinese man presented with a progressively growing perianal mass that had been growing for 8 years. The diameter of the perianal mass was ultimately up to 7 cm, accompanied by intermittent bleeding.

Diagnosis:
Histopathological evaluation of the punch biopsy specimen revealed BCC.

Interventions:
Total excision of the mass and transverse colostomy was performed. The postoperative pathological result was BCC, but part of the specimen's incisal margin was infiltrated by cancer. Therefore, after a month of recovery, local radiotherapy was started, and the wound healed completely. Stoma reversal was performed 4 months after the surgery.

Outcomes:
Postoperative anal function was satisfactory. The patient was asymptomatic and showed no signs of BCC recurrence one year after surgery.

Conclusion:
We present a case of isolated large perianal BCC in a patient with no known risk factor. As for huge perianal BCC, local wide resection is the preferred treatment. If the wound is large and close to the anus, transverse colostomy is needed. However, it is difficult to ensure a safe incisal margin because of the large size of the tumor; therefore, radiotherapy is also required.
Do Financial Incentives Affect Utilization for Chronically Ill Medicare Beneficiaries?
Authors: Buttorff Christine , Girosi Federico , Lai Julie , Taylor Erin A. , Lewis Sarah E. , Ma Sai , Eibner Christine 
Published: February 2022

Objective:
The objective of this study was to examine the price sensitivity for provider visits among Medicare Advantage beneficiaries.

Data Sources:
We used Medicare Advantage encounter data from 2014 to 2017 accessed as part of an evaluation for the Center for Medicare & Medicaid Innovation.

Study Design:
We analyzed the effect of cost-sharing on the utilization of 2 outcome categories: number of visits (specialist and primary care) and the probability of any visit (specialist and primary care). Our main independent variable was the size of the copayment for the visit, which we regressed on the outcomes with several beneficiary-level and plan-level control variables.

Data Collection/Extraction Methods:
We included beneficiaries with at least 1 of 4 specific chronic conditions and matched comparison beneficiaries. We did not require beneficiaries to be continuously enrolled from 2014 to 2017, but we required a full year of data for each year they were observed. This resulted in 371,140 beneficiary-year observations.

Principal Findings:
Copay reductions were associated with increases in utilization, although the changes were small, with elasticities <−0.2. We also found evidence of substitution effects between primary care provider (PCP) and specialist visits, particularly cardiology and endocrinology. When PCP copays declined, visits to these specialists also declined.

Conclusions:
We find that individuals with chronic conditions respond to changes in copays, although these responses are small. Reductions in PCP copays lead to reduced use of some specialists, suggesting that lowering PCP copays could be an effective way to reduce the use of specialist care, a desirable outcome if specialists are overused.
Comparing Gold-standard Copayment and Coinsurance Values From Claims Processing Engines to Values Derived From Behavioral Health Claims Databases
Authors: Friedman Sarah A. , Xu Haiyong , Azocar Francisca , Ettner Susan L. 
Published: February 2022

Background:
While researchers use patient expenditures in claims data to estimate insurance benefit features, little evidence exists to indicate whether the resulting measures are accurate.

Objective:
To develop and test an algorithm for deriving copayment and coinsurance values from behavioral health claims data.

Subjects:
Employer-sponsored insurance plans from 2011 to 2013 for a national managed behavioral health organization (MBHO).

Measures:
Twelve benefit features, distinguishing between carve-in and carve-out, in-network and out-of-network, inpatient and outpatient, and copayment and coinsurance, were created. Measures drew from claims (claims-derived measures), and benefit feature data from a claims processing engine database (true measures).

Study Design:
We calculate sensitivity and specificity of the claims-derived measures’ ability to accurately determine if a benefit feature was required and for plan-years requiring the benefit feature, the accuracy of the claims-derived measures. Accuracy rates using the minimum, 25th, 50th, 75th, and maximum claims value for a plan-year were compared.

Principal Findings:
Sensitivity (82% or higher for all but 3 benefit features) and specificity (95% or higher for all but 2 benefit features) were relatively high. Accuracy rates were highest using the 75th or maximum claims value, depending on the benefit feature, and ranged from 69% to 99% for all benefit features except for out-of-network inpatient coinsurance.

Conclusions:
For most plan-years, claims-derived measures correctly identify required specialty mental health copayments and coinsurance, although the claims-derived measures’ accuracy varies across benefit design features. This information should be considered when creating claims-derived benefit features to use for policy analysis.
Utilization and Effectiveness of eHealth Technology in the Follow‐up of Celiac Disease
Authors: Månsson Alice Loft , Meijer‐Boekel Caroline , Mårild Karl 
Published: February 2022

ABSTRACTObjectives:To systematically review the literature on the utilization and effectiveness of electronic‐health technologies (eHealth), such as smartphone applications, in managing patients with celiac disease (CD).Methods:PubMed, Scopus, and the Cochrane Library were all searched (until February 2021). Inclusion criteria were full‐text English articles reporting original data on the use of eHealth technologies in the follow‐up of CD patients, with no age restriction. Exclusion criteria were studies only using non‐interactive websites and phone consultation as the primary eHealth method. The results were summarized narratively.Results:Using identified keywords, 926 unique studies were identified. After title and abstract screening by two independent reviewers, 26 studies were reviewed in full text. Finally, eight studies were included in this systematic review, and their quality appraised using standardized forms. Of the eight studies, six were randomized‐controlled trials, one mixed‐methods study, and one cross‐sectional, observational study. Studies were assessed to be of “low” to “moderate” methodological quality. Studied eHealth technologies included web‐based interventions, smartphone applications, text messaging, and online consultations. The most consistently reported effects related to improved quality of life (number of studies = 4), knowledge on CD (n = 3), and dietary adherence (n = 2); notably, only one study reported reduced costs of eHealth vs. standard (in‐office) care.Conclusions:Although eHealth has the potential to improve the management of CD, so far, the research in the field is scarce and generally of low‐moderate methodological quality. Hence, the effectiveness of eHealth in CD management remains uncertain, and more high‐quality evidence is required before its utility is known.
Anaemia in Children Receiving Home Parenteral Nutrition
Authors: Cernat Elena , Ahmad Tania , Hill Susan , Köglmeier Jutta 
Published: February 2022

ABSTRACTObjectives:Children receiving home parenteral nutrition (HPN) are at risk of iron deficiency anaemia. Our aim was to determine the incidence of iron deficiency anaemia in paediatric HPN and efficacy of each therapeutic approach.Methods:Retrospective data collection from children receiving HPN at a tertiary referral centre over a 12‐month period (2015). Full blood count, and whenever available, ferritin and C‐reactive protein were collected at least 3 times for each patient. Liver function tests were checked at the beginning and end of the study and number of blood transfusions/iron infusions recorded.Results:Forty‐one HPN patients (61% girls; 51% motility disorder, 29% enteropathy, 20% short bowel syndrome) were identified. Eighty‐three percent of children were anaemic at the beginning of the study with the number decreasing to 73% by the end. Iron deficiency anaemia was most commonly seen and treated with blood transfusion in 46% of cases and iron infusions in 29%. There was no statistical difference in the level of haemoglobin improvement between the 2 treatments (50% vs 33%, P = 0.657) nor a significant difference in haemoglobin (g/L) level achieved. The results for both were, however, more favourable in the infusion group. Patients receiving transfusions had a significantly higher incidence of abnormal liver function compared with those who hadinfusions (93% vs 37%, P = 0.009).Conclusions:Iron deficiency anaemia is common in children receiving HPN. A large proportion of patients still receive blood transfusions as first‐line therapy but intravenous iron can be a suitable alternative. Treatment guidelines are required.
Neonatal Antibiotics and Food Allergy Are Associated With FGIDs at 4–6 Years of Age
Authors: Kamphorst Kim , Vlieger Arine M. , Oosterloo Berthe C. , Garssen Johan , van Elburg Ruurd M. 
Published: February 2022

ABSTRACTObjectives:Antibiotics may contribute to the development of functional gastrointestinal disorders (FGIDs). This study aimed to determine whether antibiotics during the first week of life, infantile colic in the first year of life, gut‐associated immune markers at 1 year of age, and allergies at 4–6 years of age in term‐born children were associated with a higher prevalence of FGIDs at 4–6 years of age.Methods:A prospective observational cohort of 436 term‐born infants was followed up at the age of 4–6 years; 151 received broad‐spectrum antibiotics (AB+), and 285 healthy controls (AB−). Validated Questionnaire On Pediatric Gastrointestinal Symptoms‐Rome III and International Study of Asthma and Allergy in Childhood questionnaires were sent to parents of 418 available children. The independent t‐test, chi‐squared test or non‐parametric test and logistic multivariate regression analyses were used.Results:In total, 340 of 418 (81%) questionnaires were completed. Only the presence of functional abdominal pain was significantly higher in AB+ than AB− (4% vs 0.4%, respectively, P = 0.045). Children with food allergy fulfilled significantly more often the criteria for irritable bowel syndrome (IBS) and abdominal migraine (26% vs 9%, P = 0.002 and 7% vs 1%, P = 0.043, respectively) compared to non‐allergic children. No differences in FGIDs existed at the age of 4–6 years between children with and without a history of infantile colic. There were significant differences in gut‐associated immune markers between children with and without FGIDs.Conclusion:Antibiotics during the first week of life resulted in a higher risk for functional abdominal pain at 4–6 years. Furthermore, food allergy was associated with IBS and abdominal migraine at 4–6years.
Mechanical Complications in Central Lines Using Taurolidine Versus Ethanol Lock Therapy in Children With Intestinal Failure
Authors: Strauss Jaclyn , Boctor Dana Liza , Silverman Jason A. , Casey Linda 
Published: February 2022

ABSTRACTObjectives:Ethanol lock therapy (ELT) is effective in reducing rates of catheter‐related‐bloodstream infections (CRBSI) in the pediatric intestinal failure (IF) population; however, ELT may increase the risk of line occlusion and breakage, significantly impacting preservation of vascular access. During a period of ethanol shortage, Health Canada temporarily approved the use of taurolidine lock therapy (TLT) in pediatric iF patients previously utilizing ELT. This provided a unique opportunity to directly compare rates of central venous catheter (CVC) complications, including CRBSi, breaks, occlusions, repairs and replacements in patients who utilized both ELT and TLT.Methods:A retrospective study of pediatric IF patients managed by three Western Canadian intestinal rehabilitation programs was performed. Event rates in patients who used both ELT and TLT during the study period were compared using Poisson regression analysis.Results:In 13 patients with 10,187 catheter days (CDs), TLT (vs ELT) had lower rates of CVC breaks (1.11 vs 5.19/1000 CDs, P < 0.001), occlusions (0.83 vs 4.06/1000 CDs, P = 0.01) and repairs (1.94 vs 5.64/1000 CDs, P = 0.01). There was no difference in CRBSI rates (0.83 vs 2.03/1000 CDs, P = 0.25) or rates of CVC replacements due to mechanical events (0.28 vs 1.81/1000 CDs, P = 0.08).Conclusions:Although there was no difference in CRBSI rates, TLT was associated with lower rates of mechanical complications compared to ELT in this study. Taurolidine may be a suitable alternative to ethanol in preventing CRBSI and may be associated with improved preservation of central lines in children with IF.
Can We Be at Peace With Unsolvable Suffering? A Qualitative Study Exploring the Effectiveness of Supportive Communication and Resilience Building
Authors: Nagano Hiroaki , Chida Keiko , Ozawa Taketoshi 
Published: February 2022

The authors provided six 180-minute interpersonal assistance workshops using teaching materials from the End-of-Life Care Association: 90 minutes each on supportive communication and role-playing. The content included the following:・ Suffering people are “at peace” with someone who understands their suffering, which starts with building a relationship through empathetic listening. The goal is not to “understand them” but for them to “feel understood.”・ Realizing the suffering of others and recognizing the internal moral and emotional strength of those who live with suffering.・ Resilience building: helping caregivers face difficulties even when helpless; remembering one's support networks and valuing oneself.Participants (n = 114) wrote reflective journals after each session. Two domains and 10 key themes were identified through thematic analysis. The domains comprised topics on the importance of using listening techniques, such as repetition, waiting in silence, and asking questions (not to understand but for dialogue). The 3-month postinterviews revealed that participants could ease their sense of weakness by helping suffering people, which is relevant to work, grief care, and daily life. Changes in relationships between participants and patients were also identified. Role-playing can teach supportive communication, such as listening attentively and accepting others, which may help supporters engage with people experiencing incurable suffering.
The Limited Value of Prior Change in Predicting Future Progression of Juvenile-onset Myopia
Authors: Mutti Donald O. , Sinnott Loraine T. , Brennan Noel A. , Cheng Xu , Zadnik Karla 
Published: February 2022

SIGNIFICANCE
Identifying children at highest risk for rapid myopia progression and/or rapid axial elongation could help prioritize who should receive clinical treatment or be enrolled in randomized clinical trials. Our models suggest that these goals are difficult to accomplish.

PURPOSE
This study aimed to develop models predicting future refractive error and axial length using children's baseline data and history of myopia progression and axial elongation.

METHODS
Models predicting refractive error and axial length were created using randomly assigned training and test data sets from 916 myopic participants in the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error Study. Subjects were 7 to 14 years of age at study entry with three consecutive annual visits that included cycloplegic A-scan ultrasound and autorefraction. The effect of adding prior change in axial length and refractive error was evaluated for each model.

RESULTS
Age, ethnicity, and greater myopia were significant predictors of future refractive error and axial length, whereas prior progression or elongation, near work, time outdoors, and parental myopia were not. The 95% limits for the difference between actual and predicted change were ±0.22 D and ±0.14 mm without prior change data compared with ±0.26 D and ±0.16 mm with prior change data. Sensitivity and specificity for identifying fast progressors were between 60.8 and 63.2%, respectively, when the cut points were close to the sample average. Positive predictive value and sample yield were even lower when the cut points were more extreme.

CONCLUSIONS
Young, more myopic Asian American children in the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error Study were the most likely to progress rapidly. Clinical trials should expect average progression rates that reflect sample demographics and may have difficulty recruiting generalizable samples that progress faster than that average. Knowing progression or elongation history does not seem to help the clinical decision regarding initiating myopia control.