bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alpha-Adrenergic Mechanisms in the Cardiovascular Hyperreactivity to Norepinephrine-Infusion in Essential Hypertension
Authors: Walther Lisa-Marie , von Känel Roland , Heimgartner Nadja , Zuccarella-Hackl Claudia , Stirnimann Guido , Wirtz Petra H. 
Published: July 2022

AimsEssential hypertension (EHT) is characterized by cardiovascular hyperreactivity to stress but underlying mechanism are not fully understood. Here, we investigated the role of α-adrenergic receptors (α-AR) in the cardiovascular reactivity to a norepinephrine (NE)-stress reactivity-mimicking NE-infusion in essential hypertensive individuals (HT) as compared to normotensive individuals (NT).Methods24 male HT and 24 male NT participated in three experimental trials on three separate days with a 1-min infusion followed by a 15-min infusion. Trials varied in infusion-substances: placebo saline (Sal)-infusions (trial-1:Sal+Sal), NE-infusion without (trial-2:Sal+NE) or with non-selective α-AR blockade by phentolamine (PHE) (trial-3:PHE+NE). NE-infusion dosage (5µg/ml/min) and duration were chosen to mimic duration and physiological effects of NE-release in reaction to established stress induction protocols. We repeatedly measured systolic (SBP) and diastolic blood pressure (DBP) as well as heart rate before, during, and after infusions.ResultsSBP and DBP reactivity to the three infusion-trials differed between HT and NT (p’s≤.014). HT exhibited greater BP reactivity to NE-infusion alone compared to NT (trial-2-vs-trial-1: p’s≤.033). Group differences in DBP reactivity to NE disappeared with prior PHE blockade (trial-3: p=.26), while SBP reactivity differences remained (trial-3: p=.016). Heart rate reactivity to infusion-trials did not differ between HT and NT (p=.73).ConclusionOur findings suggest a mediating role of α-AR in DBP hyperreactivity to NE-infusion in EHT. However, in SBP hyperreactivity to NE-infusion in EHT, the functioning of α-AR seems impaired suggesting that the SBP hyperreactivity in hypertension is not mediated by α-AR.
Osteoporosis and Related Health Status Among the Elderly Urban Residents in Elderly-Care Inns in Beijing, a Multicenter DXA Survey
Authors: Lin XinChao , Guo HongTao , Lian YiGang , Kou Jiajing , Wang GuangLei , Chen YiYun , Wang Juan , Han Xu , Jiang Miao , Yang QiaoHui 
Published: July 2022

BackgroundIdentification of the high risk population for osteoporosis and timely prevention are the best strategies at present. Detailed epidemiological investigation in a well-defined population is necessary to explore the population-based characteristics and risk factors of osteoporosis, thus to facilitate better prevention programs.MethodIn this prospective cross-sectional study, 1423 questionnaires were given out to the urban residents (female ≥ 40 years of age, male ≥50 years) who lived in the 27 Elderly-Care Inns interspersed among the seven central urban areas of Beijing. All participants were voluntary and underwent routine physical examination and spine and hip BMD measurements using the DXA instrument. The study protocols were approved by the Medical Ethics Committee of Dongzhimen Hospital, Beijing University of Chinese Medicine (JDZX2015079).ResultsAltogether 1407 participants fulfilled the survey. Among 359 men, the prevalence of osteoporosis, osteopenia, and normal BMD were 18.1%, 56.6%, and 25.3%, respectively; among 1048 women, the corresponding figures were 40.3%, 42.8%, and 16.9%, respectively. After adjustment of age and BMI, both hands grip strength, height loss over 3 cm, serum levels of β-CTx, PINP, and OST were the independent risk factors for osteoporosis in both men and women; besides, familial Alzheimer’s disease history in men; and history of steatohepatitis and fracture, serum levels of PTH and ALT, age of menarche, age of menopause, and duration of menstruation in women were also risk factors of osteoporosis. In both genders, the cost-effective method, which adopted both hands grip strength, height loss over 3 cm, and medical history, indicated a good predictive ability to evaluate the risk of osteoporosis (in men AUC=0.730, 95%CI=0.642~0.817; in women AUC=0.769, 95%CI=0.724~0.813).ConclusionsIn the population of elderly Beijing urban residents in Elderly-Care Inns, the prevalence of osteoporosis in women is higher than that in men and increases with aging more rapidly; the prevalence of osteopenia in men is higher than in women. The cost-effective method, including both hands grip strength, height loss over 3 cm, and familial Alzheimer’s disease history in men; fracture and steatohepatitis history as well as menstrual history in women is recommended in identifying the high-risk subjects for osteoporosis.
Alterations in Spontaneous Neuronal Activity and Microvascular Density of the Optic Nerve Head in Active Thyroid-Associated Ophthalmopathy
Authors: Zhu Pingyi , Liu Zihui , Lu Yi , Wang Yu , Zhang Danbin , Zhao Pinghui , Lin Lulu , Hussein Nimo Mohamed , Liu Xiaozheng , Yan Zhihan , Bai Guanghui , Tu Yunhai 
Published: July 2022

PurposeTo investigate changes in local spontaneous brain activity in patients with active thyroid-associated ophthalmopathy (TAO) and explore the relationship between such alterations and microvascular indices.MethodsThirty-six active TAO patients with active phase and 39 healthy controls (HCs) were enrolled in this study. All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI), neuropsychological tests, and ophthalmological examinations. The rs-fMRI-based fractional low-frequency fluctuation amplitude (fALFF) analysis methods were used to assess spontaneous brain activity in both groups. The structure (peripapillary retinal nerve fiber layer, pRNFL) and microvascular indices (the optic nerve head (ONH) whole image vessel density, ONH-wiVD, and peripapillary vessel density) were analyzed through optical coherence tomographic angiography imaging. The relationship between abnormal spontaneous brain activity and ophthalmological indices was analyzed using the Spearman’s rank correlation analysis.ResultsCompared with HCs, active TAO patients had increased fALFF in the right inferior temporal gyrus (R.ITG) and left posterior cingulate gyrus (L.PCC), but decreased fALFF in the right calcarine (R.CAL). The fALFF values in L.PCC were positively correlated with peripapillary vessel density, whereas fALFF values in R.CAL were negatively related to peripapillary vessel density.ConclusionsThis study demonstrates that changes in spontaneous brain activity of active TAO are accompanied by peripapillary microvascular variations. These results provide insights into the pathophysiological mechanisms of active TAO. In addition, the combination of fALFF values and peripapillary vessel density may be served as important references for better clinical decision making.
Plasma Apolipoproteins Predicting the Occurrence and Severity of Diabetic Retinopathy in Patients With Type 2 Diabetes Mellitus
Authors: Zhang Xinyuan , Nie Yao , Gong Zhizhong , Zhu Meidong , Qiu Bingjie , Wang Qiyun 
Published: July 2022

ObjectiveApolipoproteins are amphipathic molecules and the major components of plasma lipoproteins. This study aims to investigate the effects of dysregulated apolipoprotein (apo) profiles and their ratios on type 2 diabetes mellitus (T2DM) and diabetic retinopathy (DR) further to test the hypothesis that altered serum level of apolipoproteins is strong biomarkers for DR.Research Design and MethodsThis case-control study consists of 157 patients with T2DM including DM without DR, non-proliferative DR (NPDR), and proliferative DR (PDR). Fifty-eight age- and sex-matched healthy subjects were enrolled as normal controls. Blood biochemistry profile including serum levels of glucose, glycated hemoglobin (HbA1c), lipid profile [total cholesterol (TC), Triglycerides (TG), high and low-density lipoprotein (HDL-C and LDL-C)] was estimated. Apolipoproteins (apos, A-I, A-II, B, C-II, C-III, and E) was evaluated by protein chips (Luminex technology). Apolipoprotein ratios and arteriosclerosis-associated plasma indices were calculated. The Kruskal–Wallis test, independent sample t-test or Mann–Whitney U test, and multivariate regression analysis were performed to investigate the association of serum lipid biomarkers and the DR severity.ResultsSerum level of apoA-I was negatively correlated with TC-(HDL-C)/HDL-C (p &lt; 0.001), fasting glucose (p &lt; 0.001), HbA1c (p &lt; 0.001), and (p&lt;0.001), while apoE, apoC-II/apoC-III, apoA-II/apoA-I were positively correlated with above traditional biomarkers (p &lt; 0.001). Single variable logistic analysis results showed that body mass index (BMI) (p = 0.023), DM duration (p &lt; 0.001), apoE (p &lt; 0.001), apoC-II/apo C-III (p &lt; 0.001), apoE/apoC-II (p &lt; 0.001), atherogenic index (p = 0.013), fasting glucose (p &lt; 0.001), HbA1c (p &lt; 0.001), LPA (p = 0.001), and LDL-C/HDL-C (p = 0.031) were risk factors for the occurrence and severity of DR. Multivariate logistic regression mode showed that apoC-II/apoC-III and apoB/non–HDL-C (p &lt; 0.001) as well as apoE/apoC-II (p = 0.001) were the independent risk factors for the occurrence and severity of DR—apopA-I and apoA-II are protective factors for DR—after controlling for the duration of DM, HbA1c, fasting glucose, and LPA.ConclusionsapoE, apoC-II/apoC-III, apoE/apoC-II, and apoB/non–HDL-C could be used as novel biomarkers for occurrence and severity of DR, whereas apoA-I and apoA-II resulted as protective factors for DR.
Clinical advantages and neuroprotective effects of monitor guided fang’s capillary fascia preservation right RLN dissection technique
Authors: Shi Qian , Xu Jiaqi , Fang Jugao , Zhong Qi , Chen Xiao , Hou Lizhen , Ma Hongzhi , Feng Lin , He Shizhi , Lian Meng , Wang Ru 
Published: July 2022

ObjectiveTo investigate the feasibility and advantages of Fang’s capillary fascia preservation right recurrent laryngeal nerve (RLN) dissection technique (F-R-RLN dissection) with preservation of the capillary network and fascia between the RLN and common carotid artery for greater neuroprotective efficiency compared with traditional techniques.MethodsWe retrospectively analyzed 102 patients with papillary thyroid carcinoma undergoing right level VI lymph node dissection in our department from March 2021 to January 2022. Sixty patients underwent F-R-RLN dissection (the experimental group) and 42 patients underwent standard dissection (the control group). The intraoperative electrical signal amplitude ratios of the RLN, the number of dissected lymph nodes, and the preservation rates of the parathyroid glands were recorded and compared between the two groups.ResultsThe electrical signal amplitude ratio of the lower neck part point of the RLN to the upper laryngeal inlet point in the experimental group was significantly lower than the ratio in the control group (p = 0.006, Z-score = -2.726). One patient suffered transient RLN paralysis in both groups, but this resolved within 1 month after operation. There were no significant differences between the two groups in terms of the number of level VIa or level VIb lymph nodes dissected, nor in the rate of preservation of the parathyroid glands.ConclusionsF-R-RLN dissection is a thorough dissection technique that is effective at preventing an electrical signal amplitude decrease in the RLN, and at preventing RLN paralysis by preserving its blood supply.
Knowledge Domains and Emerging Trends of Osteoblasts-Osteoclasts in Bone Disease From 2002 to 2021: A Bibliometrics Analysis and Visualization Study
Authors: Hou Jun , Su Hongjie , Kuang Xiaocong , Qin Wencong , Liu Kaibing , Pan Kaixiang , Zhang Bokai , Yang Sijie , Yang Shenghui , Peng Xiao , Nie Xinyu , Hua Qikai 
Published: July 2022

BackgroundOsteoblasts-Osteoclasts has been a major area in bone disease research for a long time. However, there are few systematic studies in this field using bibliometric analysis. We aimed to perform a bibliometric analysis and visualization study to determine hotspots and trends of osteoblasts-osteoclasts in bone diseases, identify collaboration and influence among authors, countries, institutions, and journals, and assess the knowledge base to develop basic and clinical research in the future.MethodsWe collected articles and reviews for osteoblasts-osteoclasts in bone diseases from the Web of Science Core Collection. In addition, we utilized scientometrics software (CiteSpace5.8 and VOSviewer1.6.18) for visual analysis of countries/regions, institutions, authors, references, and keywords in the field.ResultsIn total, 16,832 authors from 579 institutions in 73 countries/regions have published 3,490 papers in 928 academic journals. The literature in this field is rapidly increasing, with Bone publishing the most articles, whereas Journal of Bone and Mineral Research had the most co-cited journals. These two journals mainly focused on molecular biology and the clinical medicine domain. The countries with the highest number of publications were the US and China, and the University of Arkansas for Medical Sciences was the most active institution. Regarding authors, Stavros C. Manolagas published the most articles, and Hiroshi Takayanagi had the most co-cited papers. Research in this field mainly includes molecular expression and regulatory mechanisms, differentiation, osteoprotection, inflammation, and tumors. The latest research hotspots are oxidative stress, mutation, osteocyte formation and absorption, bone metabolism, tumor therapy, and in-depth mechanisms.ConclusionWe identified the research hotspots and development process of osteoblasts-osteoclasts in bone disease using bibliometric and visual methods. Osteoblasts-osteoclasts have attracted increasing attention in bone disease. This study will provide a valuable reference for researchers concerned with osteoblasts-osteoclasts in bone diseases.
Determinants of quality of life among elderly patients with type 2 diabetes in northwest of iran: based on problem areas in diabetes
Authors: Moghaddam Hamed Rezakhani , Sobhi Eslam , Soola Aghil Habibi 
Published: July 2022

BackgroundDiabetes is a metabolic disease characterized by chronic hyperglycemia, leading to damage to various organs of the patients and a reduction of their life expectancy and quality of life (QOL). The aim of this study was to explore the determinants of the QOL based on the Problem Areas in Diabetes (PAID).MethodsThis cross-sectional study was carried out in an Iranian diabetic clinic in Ardabil. The PAID, the short form health survey (SF-12), and the sociodemographic questionnaire were all employed. Using the census sample method, 266 elderly people with type 2 diabetes from the lone diabetic clinic at Ardabil took part in this study. One-way ANOVA, t-test, one-sample Kolmogorov–Smirnov test, and multiple regression were used to analyze the data.ResultsData analysis showed that there was a statistically negative significant relationship between the QOL dimensions and the triple domains of PAID (p &lt; 0.01). In the final model of the predictors of the QOL, treatment barriers, psychological distress related to diabetes management, the type of treatment, age, and the duration of diabetes were statistically significant predictors of the QOL dimensions (p&gt;0.05).ConclusionIndividual characteristics and factors connected to health services should be prioritized in any intervention program aimed at improving the QOL of elderly patients with diabetes. Psychological distress should be considered in addition to regular physician visits.
An analysis of the characteristics of precipitation in the Northeast passage and its relationship with sea ice
Authors: Cheng Maoce , Qiu Yubao , Yang Meng , Huang Lin , Chen Jianguo , Li Yang 
Published: July 2022

Precipitation is an important part of the atmospheric circulation in the Arctic and is of great significance to the energy budget and hydrological characteristics of the Arctic region. The distribution of precipitation affects the exchange of energy, which then affects the Arctic sea ice indirectly. Arctic precipitation impacts the sea surface albedo, which leads to changes in the sea ice concentration (SIC) and the energy exchange between the sea, ice, and air. In this study, GPM IMERG precipitation data, which have a spatial resolution of 0.1°, were used to analyze the characteristics of precipitation in the Northeast Passage (NEP) from May to December during the period 2011–2020. This analysis of the amount of precipitation and its distribution were performed for the Barents Sea, Kara Sea, Laptev Sea, and East Siberian Sea. The relationship between precipitation and sea ice was also explored. The results show that, during the study period, the average precipitation over the Barents Sea from May to December was 57–561 mm/year and that this area had the highest precipitation in the NEP. For the Kara Sea, the average precipitation for May to December was 50–386 mm/year and for the East Siberian Sea and the Laptev Sea it was 48–303 mm/year and 53–177 mm/year, respectively. For the NEP as a whole, September was found to be the month with the highest average precipitation. An analysis of the correlation between the precipitation and the SIC gave a correlation coefficient of −0.792 for the study period and showed that there is a 15-day delay between the precipitation increase and the decrease in SIC. The analysis of the precipitation data in these areas thus showed that precipitation is related to SIC and is of great importance to understanding and predicting the navigable capacity of the NEP.
Effects of Several Organic Fertilizers on Heavy Metal Passivation in Cd-Contaminated Gray-Purple Soil
Authors: Wang Luyao , Liu Siqi , Li Jianfeng , Li Shunqi 
Published: July 2022

Soil heavy metal pollution has become a major ecological and environmental problem and a serious threat to global food security. Organic fertilizer can not only improve soil quality and provide nutrients for plants but also reduce the harm of heavy metal ions to a certain extent, meaning it has become a current research hotspot in the field of heavy metal passivation. In this paper, a completely combined experimental design was used to compare the effects of five organic fertilizers [nutshell organic fertilizer (NOF), pig manure organic fertilizer (PMOF), sludge organic fertilizer (SOF), humus soil organic fertilizer (HSOF) and earthworm soil organic fertilizer (ESOF)] on available Cd in soil with different pollution levels at different dosages, and the passivation mechanism of soil Cd was preliminarily discussed. The results showed that all kinds of organic fertilizers were passivated by reducing the Cd availability, and their effects on the Cd availability of purple soil were closely related to the degree of soil pollution and the amount of organic fertilizers. The passivation effect of moderate Cd-contaminated soil was the best, which increased with the increase of organic fertilizer application rate, and the effects of NOF and SOF were the best. However, the passivation effect of organic fertilizers on soil Cd was the worst in mild Cd-contaminated soil, especially ESOF. The results of Cd morphological correlation analysis showed that Exe-Cd and FeMnOx-Cd in the soil had significantly positive contributions to available Cd, while Res-Cd showed significantly negative contributions. And in moderate Cd contaminated soil, Exe-Cd content decreased by 7.12%–28.50%, while Res-Cd content increased by 19.74%–65.81%. In addition, the content of available Cd in soil decreased first and then increased with time after adding organic fertilizer, and reached the lowest value at 15 days and stabilized after 60 days. The conclusion of this paper can provide a theoretical basis for the rational use of organic fertilizer to reduce the bioavailability of cadmium in Gray-Purple soil.
Modeling the Impact of Cotton Production on Economic Development in Benin: A Technological Innovation Perspective
Authors: Chabi Simin Najib Dafia , Fei Chen , Dilanchiev Azer , Romaric Samson 
Published: July 2022

This research provides an in-depth understanding of cotton production in Benin. The analysis explored the effects of cotton production on economic growth using a vector error correction model (VECM). Prior to the VECM, a descriptive analysis was conducted on a time series database collated over 56 years (1965–2021) from national and international organizations including World Bank, the United States Department of Agriculture, and the National Accounts. Depending on the availability of the information over this period, the data were trimmed down to enable a better overview of the trend for variable of interest. Thus, the review of the trend for agricultural land (hectares) for cotton observed from 1965 to 2021 revealed that the trend evolves over the years in three different patterns, while the yields demonstrate four patterns over the same period. For the VECM analysis that permits to understand the long- and short-term relation, the time bound covers 30 years from 1990 to 2019 given the availability of data for all the variables used for the model. The findings highlighted that a strong and positive connection is found between cotton export and economic growth and a long-term relation between the human capital and the economic growth in Benin. A rapid human capital development will increase quality of the employment generation, and the country’s economy will adjust upward. Furthermore, a short-run coefficient unveils feedback necessary in a relative level of investment to bring back the economic growth to equilibrium. From these findings discussed in this study, the government of Benin is commended to diversify the production of cotton through a town target policy.
The Dilemma of Public Hearings in Land Expropriation in China Based on Farmers’ Satisfaction
Authors: Jiang Lin , Sun Li , Fu Zhenyi , Qi Rui , Tang Tao , Lin Qiaowen 
Published: July 2022

Although public hearings have been introduced into Chinese land expropriation as an important democratic supervision and conflict resolution mechanism for more than 15 years, there is a dearth of research into its qualities. Taking the farmers’ satisfaction with the public hearings as the critical quality indicator, this article analyzes the dilemma of this special institution in Chinese land expropriation. Process tracing is employed to analyze the design defect of the public hearing institution. Farmers’ satisfactions with the public hearings are measured by a questionnaire, and the factors are examined by a structural equation model based on the theories of expectancy disconfirmation and procedural fairness. It is concluded that the distorted procedure and the inconsiderate arrangement affect farmers’ perceived procedural fairness and decrease their satisfaction with hearings. In order to solve the dilemma of public participation in land expropriation, the relevant authorities should start from the source of affecting farmers’ satisfaction.