bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dosimetric and Clinical Risk Factors for the Development of Maxillary Osteoradionecrosis in Adenoid Cystic Carcinoma (ACC) Patients Treated With Carbon Ion Radiotherapy
Authors: Vischioni Barbara , Russo Stefania , Meuli Martino , Bonora Maria , Ronchi Sara , Ingargiola Rossana , Camarda Anna Maria , Imparato Sara , Preda Lorenzo , Ciocca Mario , Molinelli Silvia , Orlandi Ester 
Published: March 2022

BackgroundThe present study aims to evaluate dosimetric and clinical risk factors for the development of maxillary osteoradionecrosis (ORN) in head and neck adenoid cystic carcinoma (ACC) patients treated with carbon ion radiotherapy (CIRT).MethodsClinical data and treatment plans of ACC patients, consecutively treated from January 2013 to September 2016 within the phase II clinical trial CNAO S9/2012/C, were retrospectively reviewed. ORN and other treatment-related toxicity were graded according to the Common Terminology Criteria for Adverse Events (CTACE), version 4.0. The maxillary bone was contoured on the planning CT, and only patients receiving more than 10% of the prescription dose at their maxilla were considered for the analysis (67 patients). The volumes of maxilla receiving doses from 10 Gy (RBE) to 60 Gy (RBE) (VD), with an increment of 10 Gy (RBE), and additional clinical factors were correlated to the incidence of ORN with univariate analysis (Chi-square test). The logistic regression model was subsequently applied for multivariate analysis. Treatment plans calculated with a local effect model (LEM)-based optimization were recalculated with the modified microdosimetric kinetic model (MKM), and compared with literature data from the Japanese experience.ResultsThe median time interval from the start of CIRT to ORN appearance was 24 months (range, 8–54 months). Maxillary ORN was observed in 11 patients (16.4%). Grade 1 ORN was observed in 2 patients (18.1%), G2 in 4 (36.3%), G3 in 4 (36.3%) and G4 in 1 (9.3%). From univariate analysis, the site of the tumor, the presence of teeth within the PTV and acute mucositis correlated with the development of maxillary ORN. VD were significantly higher for all the dose levels tested in patients with maxillary ORN than patients without necrosis, according to both radiobiological models. The multivariate analysis showed that V60 significantly correlated with ORN risk.ConclusionThe volume of maxilla irradiated with high dose values was relevant for ORN development in our cohort of ACC patients. These results are in line with previously published data obtained with a different radiobiological model. Our findings might be helpful to prevent the risk of ORN in patients receiving CIRT.
A Systematic Review and Meta-Analysis of the Efficacy and Safety of Xinbao Pill in Chronic Heart Failure
Authors: Wang Yuanping , Liu Yuntao , Liu Zhongqiu , Cheng Yuanyuan , Wang Dawei 
Published: March 2022

Objective: This study aimed to clarify the efficacy and safety of Xinbao pill (XBP) as an adjunctive treatment for chronic heart failure (CHF).Methods: Randomized controlled trials (RCTs) on the efficacy and safety of XBP in the treatment of CHF were searched from the six databases. The risk of bias assessment tool recommended by Cochrane Handbook 5.1 were used to assess the methodological quality of the included studies. RevMan 5.3 software was used for meta-analysis. The subgroup and sensitivity analyses were also performed. The grading recommendations assessment, development, and evaluation (GRADE) technique were used to assess the evidence’s certainty.Results: Nine RCTs with a total of 882 patients were identified in this study. The meta-analysis demonstrated that XBP as adjunctive therapy was superior to conventional medicine alone for the treatment of CHF in improving the left ventricular ejection fraction (LVEF; MD = 5.34; 95% CI 4.68 to 5.99; p &lt; 0.001), the total effective rate (RR = 1.21; 95% CI, 1.14 to 1.29; p &lt; 0.001), the cardiac output (MD = 0.56; 95% CI 0.42 to 0.70; p &lt; 0.001), the stroke volume (MD = 3.42; 95% CI 2.03 to 4.81; p &lt; 0.001) and the 6-min walking distance (6-MWD; MD = 31.95; 95% CI 21.83 to 42.06; p &lt; 0.001), meanwhile reducing the left ventricular end-diastolic diameter (LVEDD; MD = −3.22; 95% CI −4.03 to −2.42; p &lt; 0.001) and left ventricular end-systolic dimension (LVESD; MD = −2.93; 95% CI −3.80 to −2.06; p &lt; 0.001). Regarding safety, a total of 2.4% (11/456) adverse reactions occurred in the XBP groups while 3.9% (18/456) in the control group. The outcomes’ evidentiary quality ranged from “very low” to “moderate”.Conclusion: This study indicated that XBP as adjunctive therapy combined with conventional medicine seemed to be safe and more effective than conventional medicine alone in treating CHF. However, due to the poor methodological quality of the included RCTs, further well-designed RCTs are required to confirm the efficacy and safety of XBP.
Smart Dielectric Barrier Discharge Plasma Decontamination: Spatially Targeted Decontamination With Actuated Ozone Distribution
Authors: Choudhury Bhaswati , Portugal Sherlie , Roy Subrata , Mastro Emma , Johnson Judith A. 
Published: March 2022

This study introduces spatially targeted decontamination using a synergistic combination of dielectric barrier discharge (DBD) flow actuation and ozone generation. Here, we relate the spatial distribution of local microbial decontaminations in an enclosure to that of local ozone concentrations caused by DBD ozone generation and flow actuation using two reactors with contrasting flow actuation, the Fan and Comb reactors, run at equal power of 1 ± 0.03 W for 3.5 min. Deviations in ozone concentrations and reductions of Escherichia coli on contaminated coupons over two planes were used to quantify the utilization capacity of the generated ozone to simultaneously disinfect regions of a surface placed in the planes. Results show that uniform ozone consumption by a contaminated target, i.e., targeted decontamination, lowers ozone requirements, exposure times, and reactor energy consumption for its disinfection. Furthermore, a significant positive correlation was found between local decontamination and ozone concentrations with Pearson’s correlation, ρ (34) = 0.64; p &lt; 0.001. Simulated ozone distribution using an experiment integrated simulation method, governed by DBD reactor geometry induced flow actuation and ozone reaction rates, is also presented for predicting DBD actuated spatial decontamination distribution. Our study shows an innovative approach of applying DBD plasma reactors for decontamination using flow actuation and ozone generation to achieve targeted killing with maximized ozone utilization lowering overall ozone dosage requirements, energy requirements, and exposure times.
Associations of Suicide Risk and Community Integration Among Patients With Treatment-Resistant Depression
Authors: Huong Pham Thi Thu , Wu Chia-Yi , Lee Ming-Been , Chen I-Ming 
Published: March 2022

IntroductionTreatment-resistant depression (TRD) is one of the primary causes of disability and a major risk for suicide among patients living in the community. However, the suicide risks and care needs for safety among patients with TRD during the community reintegration process appear to be underestimated. This study aimed to investigate the association between community integration and suicide risks among patients with treatment-resistant depression (TRD) with sub-analysis by gender.MethodsPatients diagnosed with major depressive disorder were recruited upon psychiatrists' referral in two general hospitals in northern Taiwan during 2018–2019. The participants who experienced more than two failed treatments of antidepressants with partial remission were defined as TRD. A structured questionnaire was used to collect socio-demographic, suicidality, and psychosocial information.ResultsIn a total of 125 participants, gender difference was identified in certain community integration aspects such as home integration, productivity, and electronic social networking. The male participants appeared to have better involvement in social contact with internet but slightly less video link than women, while women had higher level of home integration in the past month. The participants who performed worse in the social integration and better home-based activity or productivity levels had higher suicide risks including suicide ideation and overall suicide risks.ConclusionsCommunity integration levels of home, social, and productivity were associated with suicidality in terms of overall suicide risk and recent suicide ideation. Facilitation of community integration at home and life arrangements might reduce suicide risks in TRD patients.
Maternal Deprivation Increased Vulnerability to Depression in Adult Rats Through DRD2 Promoter Methylation in the Ventral Tegmental Area
Authors: Guo Zhenli , Li Shansi , Wu Jialing , Zhu Xiongzhao , Zhang Yi 
Published: March 2022

ObjectiveEarly life adversity is a risk factor for depression in adulthood; however, the underlying mechanisms are not well understood. This study aims to investigate the effect of DNA methylation of DRD2 gene on early life stress–induced depression in adult rats.MethodsNewborn Sprague–Dawley rats were randomly assigned to four groups: maternal deprivation group (MD), chronic unpredictable stress (CUS) group, maternal deprivation plus chronic unpredictable stress (MD/CUS) group, and normal control group (NOR). Behaviors were measured by open field test (OFT), sucrose preference test (SPT), and Original Research Article forced swimming test (FST). Fecal CORT level was detected by ELISA. Bisulfite amplicon sequencing PCR was used to assess methylation levels of DRD2 promoter.ResultsCUS and MD/CUS rats had a significantly shorter total distance, longer immobility time, and higher CORT level, while MD and MD/CUS rats had a significantly lower percentage of central distance, more feces, lower rate of sucrose preference, and lower levels of DRD2 protein and mRNA in the VTA than NOR rats. CUS rats showed a significantly higher DRD2 mRNA and protein levels in the VTA than NOR rats. CUS, MD, and MD/CUS rats showed a significantly higher level of DRD2 promoter methylation than NOR rats. CORT level was significantly correlated with the sucrose preference rate in SPT, the immobility time in FST, the total distance, and the number of fecal pellets in OFT. DRD2 protein level was significantly correlated with the sucrose preference rate and the number of fecal pellets. DRD2 mRNA level was significantly correlated with the percentage of central distance and the number of fecal pellets in OFT. The level of DRD2 promoter methylation was significantly correlated with the sucrose preference rate, immobility time, total distance, the percentage of central distance, and the number of fecal pellets.ConclusionsEarly life MD increased vulnerability to stress-induced depressive-like behavior in adult rats. Enhanced DRD2 promoter methylation in the VTA may increase the susceptibility to depression.
Aggressive Angiomyxoma in the Scrotum: A Case Series and Literature Review
Authors: Sun Juan , Lian Peng H. , Ye Zi X. , Dong De X. , Ji Zhi G. , Wen Jin , Li Han Z. 
Published: March 2022

PurposeAggressive angiomyxoma (AAM) was identified as a distinct clinicopathological entity in 1983. Since then, a few cases of its occurrence in the scrotum have been reported. This case series was performed to increase clinicians' understanding of the clinical features and treatment of AAM in the scrotum.MethodsWe evaluated the clinical presentations, treatments, and follow-up of two patients with AAM in the scrotum in our hospital and 34 cases reported in the literature.ResultsAmong the 36 patients, the average age was 48.3 ± 20.6 years old (range from 1 to 81); the average maximum diameter of the tumor was 8.36 cm (1.6–25 cm); the site of one (2.78%) patient was located in the epididymis, two (5.56%) in the testes, five (13.89%) in the spermatic cord, and 28 (77.77%) in the scrotum. The clinical symptoms were generally non-specific and 20 patients inadvertently discovered their slow-growing painless masses. The treatments for all these patients were surgical excision once the tumor had been found and one case underwent excision followed by radiotherapy. The median follow-up time for the remaining 32 cases was 24.5 months (1 to 84 months). Recurrence occurred in three cases (9.09%) at the primary sites and no cases of distant metastasis.ConclusionAAM of the scrotum can occur in middle-aged and elderly men. The clinical manifestation generally involves a long history of asymptomatic masses or swelling in the scrotum. Ultrasound is the most commonly used diagnostic technique but magnetic resonance imaging may be more effective. The mainly treatment is surgical excision and postoperative histopathological examination is still the gold standard for its diagnosis. Although it is locally aggressive, metastasis is extremely rare in males.
La Formación en Psicoterapia de Grupo. El necesario cambio de los programas asistenciales y de formación
Authors: Gómez Esteban Rosa 
Published: March 2022

La Psicoterapia es una disciplina, no una técnica, y ha de ser el tratamiento de elección en todas las psicopatologías. La Psicoterapia de grupo será de elección en trastornos leves y moderados, y combinada con psicofármacos en trastornos graves.
Los Programas de Formación de los futuros especialistas y los de Formación Continuada han de revisarse y actualizarse para incluir un “Área de capacitación en Psicoterapia”, en sus diversas modalidades, y poder cumplir con la cartera de servicios del Servicio Nacional de Salud (SNS) La capacitación en Psicoterapia ha de ser un objetivo prioritario en los Programas de Formación de los médicos y psicólogos residentes (MIR y PIR), y en la Formación Continuada.
La formación en Psicoterapia ha de estar íntimamente ligada a la asistencia, a las prácticas en grupos terapéuticos y familiares en los servicios públicos. Han de revisarse los Programas de Psicoterapia Asistenciales para lograr las horas de acreditación, y lograr al final de la residencia el título de psicoterapeuta. Con voluntad política se pueden organizar las horas teóricas y prácticas a lo largo de los cuatro años de residencia.
Las metodologías grupales en la formación son muy eficaces para pensar la organización del equipo, de la asistencia, docencia e investigación en el campo de la Salud Mental.
Taxonomic Revision of the pulcherrima Clade of Metschnikowia (Fungi): Merger of Species
Authors: Sipiczki Matthias 
Published: March 2022

The type strains of 10 small-spored species of the ascomycetous yeast genus Metschnikowia usually form a compact group on the phylogenetic trees inferred from barcode sequences. Based on the name of the species, which was described first (Metschnikowia pulcherrima), the group is frequently referred to as the pulcherrima clade. All strains produce the iron-chelate pigment pulcherrimin and have antagonistic effects on many microorganisms. Recent results of molecular phylogenetic, genetic, and genomic research raised doubts about the taxonomic division of the clade. Those data—combined with results obtained in this study by comprehensive analysis of primary and secondary barcode sequences, physiological tests, and hybridisation experiments—demonstrate that the species cannot be distinguished from each other by the criteria of any of the phenotypic, phylogenetic, and biological species concepts. Therefore, I propose that the species of the pulcherrima clade be merged into one species under the oldest species name, M. pulcherrima.
Les nouvelles technologies, voie royale pour améliorer l'apprentissage des sciences par l'image ?
Authors: Lowe Richard 
Published: March 2022

Como mejorar el aprendizaje de las ciencias a partir de diagramas : la tecnología es una respuesta ?

Los progresos de la informática permiten, desde ahora, la visualización y la manipulación de informaciones visuales a un punto jamás alcanzado antes. En la enseñanza de las ciencias, los diagramas son una forma importante de información visual que pueden por si mismos, provocar problemas particularmente delicados, a los estudiantes novatos en un campo científico, en la medida que exigen capacidades de interpretación dignas de un especialista. La cuestión se plantea entonces, saber si los tratamientos informáticos, tales como la animación interactiva, pueden contribuir a mejorar la eficacidad del aprendizaje de las ciencias a partir de diagramas. Caracterizar este aprendizaje como siendo una función en la construcción por el estudiante, de un modelo mental apropiado, vuelve a darle un rol - clave al tratamiento cognitivo correcto de un diagrama. Este artículo se interesa a los diferentes métodos de aprendizaje de las ciencias a partir de diagramas que utilizan la informática y estudia las diferentes maneras por las cuáles los principios derivados de la sicología cognitiva deberían ser aplicados al tratamiento clásico y al tratamiento informático de los diagramas científicos. El objetivo es de facilitar la construcción de modelos mentales de diagramas.
La aplicación de esos principios a algunos ejemplos de diagramas, ha permitido poner el acento sobre el hecho, que es probablemente esencial, que para que los métodos informáticos que intentan de mejorar el aprendizaje de las ciencias a partir de diagramas sean eficaces, es más el tratamiento “humano” de la información que su tratamiento informático.
Le “Jeu des naturalistes” : image, imaginaire et activité scientifique
Authors: Le Marec Joëlle , Scrive Martine 
Published: March 2022

El juego de los naturalistas, imágen, imaginario y actividad científica

Un análisis cualitativo de los comportamientos de un número pequeño de visitantes de la “Ciudad de las ciencias y la industria”, permite de determinar los usos del “Juego de los Naturalistas”. El objetivo del juego es de penetrar el visitante en el camino de tres naturalistas del siglo XVIII : la clasificación de las plantas por Lamarck, la identificación de los animales a partir de los huesos por Cuvier, la observación geométrica de los cristales por Haüy. Percibimos que el papel correspondiente a la imágen provoca un comportamiento de observación y una interpretación, donde la imaginación de los visitantes ocupa un lugar considerable.
Por otro lado, la lógica informática que determina cada escenario fué concevida para ser el vector del proceso que ha seguido cada naturalista. La interactividad que resulta de su uso, más o menos lúdico, condiciona la representación de la actividad científica deducida por los visitadores, en esta interpretación lo imaginario cumple un rol importante.
Le raisonnement spontané en dynamique élémentaire
Authors: Viennot Laurence 
Published: March 2022

El estudio aquí resumido se propone explorar y analizar los razonamientos espontáneos de estudiantes de dinámica elemental, desde el final de la segunda enseñanza hasta el segundo grado de la enseñanza universitaria. Una serie de investigaciones referentes a unos 2000 estudiantes (Franceses, en su mayor parte, pero también británicos y belgas) deja aparecer sorprendentes proporciones de errores o de contestaciones exactas, extrañamente estables de una categoría a otra.
Parece difícil atribuir estos resultados a la sola enseñanza escolar recibida. Al contrario estas respuestas se organizan bastante bien si se admite la existencia de un sistema explicativo espontáneo relativamente poco alterado por la enseñanza.
Utilização de biomembranas à base de extrato de barbatimão e colágeno em tratamento de ferida em um cão com loxocelismo: relato de caso / Use of biomembranes based on barbatimão extract and collagen in wound treatment in a dog with loxoscelism: case report
Authors: Santos Vithoria Regina Feitosa de Meneses , Santos Maria Roberta Celestino , Santos Carlos Vinícius Góis , Portella Viviane Gomes 
Published: March 2022

O presente trabalho teve por objetivo avaliar a eficácia de biomembranas contendo extrato de barbatimão e colagenase no processo de cicatrização de feridas. Para isso, a biomembrana foi utilizada durante o tratamento de lesão dermonecrótica apresentada por um paciente canino, da raça poodle, macho, com 1 ano e 7 meses, pesando 10,35 kg. O paciente deu entrada no Hospital Veterinário Dr. Vicente Borelli com os seguintes sintomas: taquipneia, taquicardia, região coxal do membro pélvico direito edemaciado com hematoma extenso que se estendia até a área abdominal e torácico. Após a internação foram realizados exames de sorologia para cinomose, raio X do quadril e coluna toraco-lombar, além de ultrassom e hemograma. O resultado dos exames não demonstrou nenhuma alteração clínica. No dia seguinte, após a internação, surgiu uma dermonecrose local na região abdominal lateral. Com o diagnóstico de acidente por arranha-marrom foi iniciado o tratamento da limpeza das lesões. Logo após deu-se início a desbridamento da lesão que resultou numa úlcera de intensa profundidade e extensão. Para o tratamento da úlcera foi utilizada biomembrana contendo extrato de barbatimão e colagenase. Em 6 dias de tratamento foi observado tecido de granulação, retração das bordas, menor quantidade de exsudato, redução da hiperemia e edema. Após 15 dias, o paciente exibiu melhora clínica, podendo ser evidenciada intensa retração das bordas, desaparecimento do tecido dermonecrótico, hiperemia reduzida, ausência de exsudato, tecido de granulação bastante evidenciado. Os resultados demonstram a eficácia da referida biomembrana na cicatrização da lesão dermonecrótica. Dentre os pontos positivos observados no tratamento estão a aceleração do processo de cicatrização e qualidade do reparo tecidual. Apesar da extensa ferida e da sua contaminação as propriedades anti-inflamatórias, bactericidas e de estimulação na formação de colágeno jovem, o extrato de barbatimão contribuiu para a diminuição do tempo de cicatrização e para um reparo tecidual com uma pequena cicatriz e retomada do crescimento do tecido epitelial, algo pouco observado em lesões desse tipo. A colagenase também contribuiu nesse processo já que esta apresenta uma ação estimuladora para o tecido de granulação, com aceleração do seu crescimento e enchimento do vazio da lesão, bem como sua epitelização. A biomembrana com extrato de barbatimão e colagenase apresentou eficácia no tratamento da dermonecrose, além de ter promovido qualidade no reparo tecidual do processo de cicatrização de uma ferida extensa e contaminada.