bluuebunny/crossref_metadata_2025_split huggingface dataset:
V-027 2-IN1: LAPAROSCOPIC TAPP REPAIR OF CONCURRENT SPIGELIAN AND INGUINAL HERNIAS
Authors: Ambrazevicius M 
Published: October 2022

Abstract

Aim
Spigelian hernias are rare hernias of the abdominal wall and difficult to diagnose clinically. Our aim is to report a diagnostic and surgical challenge of the combination of inguinal and Spigelian hernias.

Material & Methods
74 year old female presented with pain in right inguinal region and lump in right iliac fossa. The ultrasound scan revealed right sided Spigelian hernia up to 4 cm, right inguinal hernia up to 1 cm and incidentally detected contralateral Spigelian hernia up to 3 cm on the left side.

Results
Laparoscopic transabdominal preperitoneal (TAPP) hernia repair was performed of both right Spigelian and ipsilateral inguinal hernias. The hernia sacs were dissected and 25×15 cm polypropylene mesh was placed, covering both hernia sites. The mesh was fixed using absorbable tacks. The peritoneum was closed using barbed suture. The repair of contralateral Spigelian hernia was planned as a second stage procedure due to the present comorbidities. Operation time was 140 min. The patient was discharged on the next postoperative day. Ultrasound scan performed after 3 weeks did not show any signs of seroma, hematoma or recurrence.

Conclusions
An accurate preoperative diagnosis of Spigelian and inguinal hernias led to the safe and successful laparoscopic repair with preperitoneal mesh placement.
V-032 INTRAOPERATIVE BLEEDING AFTER SUGARBAKER REPARATION: HOW CAN I SOLVE IT ??
Authors: Delgado Morales M M , Ramírez Redondo A , Licardie Bolaños E , Bascuas Rodrigo B , Guadalajara Jurado J F 
Published: October 2022

Abstract

Aims
The parastomal hernia represents a controversial item in the wall surgery field, due to the frequency of occurrence in ostomized patients. Sugarbaker Technique constitutes the gold standard for the reparation of this type of hernia. We present the case of a 66-year-old man with a paraostomal hernia.

Material
We opted for a laparoscopic approach to solve a type III incisional hernia. We found a 6×5cm parastomal hernia, and we performed reduction of the hernial content and section of adhesions, placing a 16×15cm Dynamesh protesis around the defect as the Sugarbaker Technique describes, fixed with Tackers and Cianocrilate. At the end of the intervention, an active bleeding was seen in the hernial wall defect, which does not stop with compression nor with the application of hemostatics. We opened the mesh by cutting it in the middle, exploring the hernia cavity and verifying an active bleeding from an arterial vessel; which was controlled by electrocoagulation. A new Dynamesh protesis was placed on top of the previous one, using the same technique. We ended the intervention.

Results
The patient was discharged at the second day of the intervention without any complications. Follow-up at the first month, sixth months and one year after the intervention does not evidence any signs of recurrence.

Conclusions
We have not found any case in the literature of intraoperative bleeding using Sugarbaker technique prior to the ending of the intervention. We think that the described technique can be a useful way to solve this complication when it occurs.
V-040 LAPAROSCOPIC TRANS-ABDOMINAL PREPERITONEAL PROCEDURE (TAPP) FOR RIGHT INGUINAL HERNIA WITH HANDXTM HOOK AND NEEDLE HOLDER
Authors: Szold A , Ortenzi M 
Published: October 2022

Abstract
AIM HandX™ is a handheld, powered laparoscopic device with interchanging single-patient fully articulating instruments. It is electromechanically controlled, and, as the manual interface is handled by the surgeon, beside the patient's bed, the movements of the surgeon's wrist and fingers are translated to the instrument-articulating tip. This report is to show the feasibility and safety of this technology applied in inguinal hernia repair. MATERIALS AND METHODS We report the case of the laparoscopic repair of a right inguinal hernia using HandXTM instruments. RESULTS The index case was a 55-year-old, otherwise healthy male, with an inguinal right hernia. Three trocars were used: one 10 mm umbilical and two of 5 mm, approximately 4 cm laterally from the umbilicus and 1 cm under the level of the horizontal umbilical line. The dissection started with peritoneal cut, from the antero-superior iliac spine to the medial umbilical ligament, into the preperitoneal avascular plane. The anatomical landmarks (epigastric vessels, Cooper and Gimbernat ligaments, the corona mortis and external iliac vessels) were identified and well exposed. A polypropylene mesh was inserted from the optical trocar, placed in the appropriate position and fixed with three separated stiches handled with the articulating needle holder. The peritoneal flap was closed with a readsorbable running suture handled with the HandX instrumentation. No blood loss nor intraoperative or post-operative complications were recorded CONCLUSIONS The report showed how the HandX technology could be safely adopted to obtain both a safe dissection and an ergonomically advantageous suture in laparoscopic TAPP.
V-043 NEW CONCEPTS IN LIRA TECHNIQUE IN LAPAROSCOPIC VENTRAL HERNIA REPAIR. LIRA -LESS STEP BY STEP
Authors: Gómez Menchero J , Gila Bohorquez A , De La Herranz P , Guerrero J L , Lara Fernandez Y , Bellido Luque J , Garcia Moreno J , Navarro L , Morales Conde S 
Published: October 2022

Abstract

Introduction
LIRA (Laparoscopic Intracorporeal Rectus Aponeuroplasty) described in 2018 by our group showed advantages in preliminary results in terms of recurrence and bulging because a reduced tension in the midline in W2 defects following the EHS Classification. Otherwise permanent fixation in inlay meshes is related with and increase of pain and adhesions. We present LIRA-LESS step to step as an evolution in LIRA technique.

Material and methods
A 58 years old male affected by a M3W2 hernia. A LIRA procedure is proposed.
Step 1: adhesions release and sac content reduced.
Step 2: defect measurement and flap designed following the LIRA Technique principles with the neumoperitoneum deflated and flap mobilized and suture in the midline.
Step 3 An in lay mesh of PVDF is positioned reducing permanent fixation in cardinal points combined with Cianocrilate in a 3:1 way.
Step 4 A TAP-block anesthesia is performed in this case with Ropivacaine 2%.

Results
Operative time was 95 min. VAS 1 day was 3 and was discharge without complications. VAS 7 day in clinical office was 0. There were not recurrence or Bulkging in CT -Scan 1 month after the surgery.

Discussion
LIRA technique is a safe procedure with a low tension in the midline with good reults in terms of recurrence and bulging. LIRA-LESS concept allows a reduction in traumatic permanent fixation with good results in terms of pain and recurrence.
V-045 SAFENESS OF LIQUIBAND FIX8® IN T.A.P.P. PROCEDURE: ANALYSIS OF COSTS, POST-OPERATIVE COMPLICATIONS AND RECURRENCES
Authors: Latham L , Ballabio A , Monti E , Costa J , Marzorati A , Colombo E M , Odeh M , Garbarino S , Gianazza S , Inversini D , Ietto G , Carcano G 
Published: October 2022

Abstract

Aims
We tested the use of LiquiBand®FIX8™ versus standard TAPP procedure comparing costs, surgical time, complications, recurrence rate, chronic pain to check the feasibility of the procedure.

Materials and Methods
LiquiBand®FIX8™is a cyanoacrylic adhesive used to fix the mesh during laparoscopic procedures. It consents the avoidance of plastic or metallic fixing materials that can causes post-operative chronic pain or vascular damage

Discussion
We performer 54 TAPP procedures, 48 with standardized tack technique and 6 with LiquiBand®FIX8™. We checked the results after a 6 months follow-up and we found no difference in recurrence rate or chronic pain between the two techniques. Costs and surgical time were inferior in LiquiBand®FIX8™ group.

Conclusions
The use of LiquiBand®FIX8™is a safe and feasible procedure during TAPP to reduce the surgical time, to limit costs and to avoid intraoperative and postoperative complications that can occur with mechanical fixing materials.
V-049 E-TEP RIVES-STOPPA AND OPEN REVERSE TRANVERSUS ABDOMINIS RELEASE (TAR): A HYBRID APPROACH FOR LARGE LATERAL-INFERIOR INCISIONAL HERNIAS
Authors: García Ureña M Á , Martínez Caballero J , Medina M , Avilés A , Rial X , Robin A , Muñoz J , López-Monclús J , Blazquez-Hernando L A 
Published: October 2022

Abstract

Aim
To present hybrid approach with open/endoscopic extraperitoneal dissection for large lateral-inferior incisional hernias

Material and Methods
64 years-old man who underwent left laparoscopic nephrectomy (2019) due to hypernephroma with specimen extraction by a left oblique iliac incision. He presents L3–4 W3 incisional hernia (14×10 cm)

Technique description

Results
After 48 hours ICU admission patient was discharged to hospital ward. Drainages were removed at 2nd-4thpostoperative day and hospital stay was 5 days.

Conclusion
The hybrid approach to large lateral incisional hernias allowed us to use a large sublay mesh with an increased overlap beyond the hernia defect, trying to reduce hernia recurrence rate.
V-054 LAPAROSCOPIC REPAIR OF TWO CASES WITH OBTURATOR HERNIA; EARLY DAIGNOSED AND SUCCESSFUL RESULTS
Authors: Tirnova İ , Yarbuğ Karakayali F , Karaca A S , Fi̇li A İ 
Published: October 2022

Abstract

Aim
Obturator hernia is a rare type of groin site hernias. Early diagnosis may prevent intervention on gastrointestinal tract. In this report, we present two octogenarian female patients with early diagnosed obturator hernia.

Material & Methods
In first case, 83-year-old female admitted to the Emergency Room(ER) for her left groin site pain. Physical examination was unremarkable except mild tenderness on left groin site. There was no abdominal distention. Ultrasound was negative for surgical aspect. Computerized tomography(CT) scans revealed left sided obturator hernia. Laparoscopic trans abdominal pre-peritoneal (TAPP) repair was planned. Peritoneum was opened about 4–5 cm cranial side of the hernia defect and preperitoneal space was prepared. Cone-shaped 5×5 cm polypropylene mesh have placed in the obturator canal. Afterwards 15×15 cm polypropylene mesh was placed to the groin area, covering all possible hernia sites. The mesh was fixed by tuckers and the peritoneal defect was closed.
Second case, 84-year-old female admitted to ER with left groin and knee. There was no sign of inguinal hernia on physical examinitation except mild tenderness on left groin site. CT proved the intestinal segment within the left-sided obturator hernia sac. TAPP repair with mesh plug was planned. Peritoneum was opened and previously prepared cone-shaped 15×15 cm polypropylene mesh have placed in the obturator canal and fixed by tuckers. The peritoneal defect was closed and operation completed.

Results
Both patients were discharged at postoperative day 2. 60 day-postoperative periods were uneventfull.

Conclusion
The most crucial factor affecting the results is timing of surgery in obturator hernia.
Analysis of a mechanistic model of corals in association with multiple symbionts: within-host competition and recovery from bleaching
Authors: Brown Alexandra Lynne , Pfab Ferdinand , Baxter Ethan C , Detmer A Raine , Moeller Holly V , Nisbet Roger M , Cunning Ross 
Published: October 2022

Abstract
Coral reefs are increasingly experiencing stressful conditions, such as high temperatures, that cause corals to undergo bleaching, a process where they lose their photosynthetic algal symbionts. Bleaching threatens both corals’ survival and the health of the reef ecosystems they create. One possible mechanism for corals to resist bleaching is through association with stress-tolerant symbionts, which are resistant to bleaching but may be worse partners in mild conditions. Some corals have been found to associate with multiple symbiont species simultaneously, which potentially gives them access to the benefits of both stress-sensitive and -tolerant symbionts. However, within-host competition between symbionts may lead to competitive exclusion of one partner, and the consequences of associating with multiple partners simultaneously are not well understood. We modify a mechanistic model of coral-algal symbiosis to investigate the effect of environmental conditions on within-host competitive dynamics between stress-sensitive and -tolerant symbionts and the effect of access to a tolerant symbiont on the dynamics of recovery from bleaching. We found that the addition of a tolerant symbiont can increase host survival and recovery from bleaching in high-light conditions. Competitive exclusion of the tolerant symbiont occurred slowly at intermediate light levels. Interestingly, there were some cases of post-bleaching competitive exclusion after the tolerant symbiont had helped the host recover.
Copy number variation of horse Y chromosome genes in normal equine populations and in horses with abnormal sex development and subfertility: relationship of copy number variations with Y haplogroups
Authors: Castaneda Caitlin , Radović Lara , Felkel Sabine , Juras Rytis , Davis Brian W , Cothran Ernest Gus , Wallner Barbara , Raudsepp Terje 
Published: October 2022

Abstract
Structural rearrangements like copy number variations in the male-specific Y chromosome have been associated with male fertility phenotypes in human and mouse but have been sparsely studied in other mammalian species. Here, we designed digital droplet PCR assays for 7 horse male-specific Y chromosome multicopy genes and SRY and evaluated their absolute copy numbers in 209 normal male horses of 22 breeds, 73 XY horses with disorders of sex development and/or infertility, 5 Przewalski’s horses and 2 kulans. This established baseline copy number for these genes in horses. The TSPY gene showed the highest copy number and was the most copy number variable between individuals and breeds. SRY was a single-copy gene in most horses but had 2–3 copies in some indigenous breeds. Since SRY is flanked by 2 copies of RBMY, their copy number variations were interrelated and may lead to SRY-negative XY disorders of sex development. The Przewalski’s horse and kulan had 1 copy of SRY and RBMY. TSPY and ETSTY2 showed significant copy number variations between cryptorchid and normal males (P &lt; 0.05). No significant copy number variations were observed in subfertile/infertile males. Notably, copy number of TSPY and ETSTY5 differed between successive male generations and between cloned horses, indicating germline and somatic mechanisms for copy number variations. We observed no correlation between male-specific Y chromosome gene copy number variations and male-specific Y chromosome haplotypes. We conclude that the ampliconic male-specific Y chromosome reference assembly has deficiencies and further studies with an improved male-specific Y chromosome assembly are needed to determine selective constraints over horse male-specific Y chromosome gene copy number and their relation to stallion reproduction and male biology.
Rapid cefiderocol NP test for detection of cefiderocol susceptibility/resistance in Enterobacterales
Authors: Nordmann Patrice , Bouvier Maxime , Poirel Laurent , Sadek Mustafa 
Published: October 2022

Abstract

Background
Cefiderocol is among the latest generation of commercialized antibiotics against a large variety of MDR Gram-negative bacteria including carbapenem-resistant Enterobacterales and non-fermenters such as Pseudomonas aeruginosa and Acinetobacter baumannii. Cefiderocol susceptibility testing, a key element for implementing rapidly a cefiderocol-based treatment, might be still challenging.

Objectives
To develop a rapid culture-based test, Rapid Cefiderocol NP test, for the identification of cefiderocol resistance among MDR Enterobacterales.

Methods
The Rapid Cefiderocol NP test is based on glucose metabolization when bacterial growth occurs and the detection of bacterial growth in the presence of cefiderocol at 64 mg/L using iron-depleted CAMHB. Bacterial growth is visually detectable by a red-to-yellow colour change of red phenol, a pH indicator. A total of 74 clinical enterobacterial isolates from various clinical sources and of worldwide origin, among which 42 isolates were cefiderocol resistant, were used to evaluate the test performance.

Results
The sensitivity and specificity of the test were found to be 98% and 91%, respectively, by comparison with the reference broth microdilution (BMD) method. All positive results were obtained within 3 h after incubation at 35°C ± 2°C, that is a gain of time of ca. 18 h (1 day) compared with currently used techniques for susceptibility testing (BMD method).

Conclusions
This novel test is rapid, highly sensitive, specific, easily interpretable, and easy to implement in routine microbiology laboratories. Such a test may rapidly and accurately provide the information needed for the implementation of adequate cefiderocol-based treatment.
Development of an international survey tool to measure confidence and current antimicrobial stewardship practices of hospital pharmacists
Authors: Weier Naomi , Thilly Nathalie , Howard Philip , Demore Béatrice , Patel Rahul , Pulcini Céline , Zaidi Syed Tabish R 
Published: October 2022

Abstract

Background
Pharmacists are identified as key members of hospital antimicrobial stewardship (AMS) teams in international guidelines. Developing an international standardized tool to measure hospital pharmacists’ confidence and practices of AMS will encourage knowledge sharing and better networking between hospital pharmacists internationally.

Objectives
To develop a survey tool that can be used internationally to assess pharmacists’ knowledge, confidence, perceived barriers and current AMS practices.

Methods
A project team was formed to refine the survey tool that was initially used in a previous survey study. Following revision by the project team, a revised survey tool was sent to the ESCMID Study Group for Antimicrobial Stewardship (ESGAP). Feedback from the ESGAP members was considered by the project team to finalize the survey tool.

Results
A total of 88 changes were made to the survey tool after revision by the project team. A total of 43/216 (19.9%) of ESGAP members provided feedback on the survey tool, which led to a further 19 revisions. ESGAP members were agreeable to the questions in the survey tool, with &gt;50% agreeing that each question was suitable. The final survey tool consisted of 42 questions, reduced from 72 questions in the original survey.

Conclusions
An international survey tool to measure hospital pharmacists’ confidence and practices of AMS was developed. This tool will help the wider hospital pharmacy community in conducting local studies on current AMS practices and to identify areas where further support is needed. Use of a standardized survey tool will also allow individual regions/countries to compare their data with other countries to identify potential quality improvement programmes.
Beyond the Victimhood Narrative: A Case Study of Unexpectedly Successful Collectivization in Communist Poland
Authors: Wylegała Anna 
Published: October 2022

Abstract
This article is a micro-historical study of the collectivization of agriculture carried out by the communist authorities in Central and Eastern Europe after 1945. Using the example of the village of Gierczyce in the Kielce region (Central Poland), it shows under what conditions collectivization, resisted in most of the Polish countryside, was able to succeed, and it traces the long-term effects of this process on Gierczyce’s social structure and social relations. It also analyzes this rural community’s contemporary memory of the emergence and functioning of the production cooperative. Thus, it critically engages with, and questions, the “resistance paradigm” dominant in studies of collectivization. Enriched with a broader regional and national comparative context, the article is based on the analysis of archival material from central and regional archives, personal documents, and extensive field research.
Barley endosomal MONENSIN SENSITIVITY1 is a target of the powdery mildew effector CSEP0162 and plays a role in plant immunity
Authors: Liao Wenlin , Nielsen Mads E , Pedersen Carsten , Xie Wenjun , Thordal-Christensen Hans 
Published: October 2022

Abstract
Encasements formed around haustoria and biotrophic hyphae as well as hypersensitive reaction (HR) cell death are essential plant immune responses to filamentous pathogens. In this study we examine the components that may contribute to the absence of these responses in susceptible barley attacked by the powdery mildew fungus. We find that the effector CSEP0162 from this pathogen targets plant MONENSIN SENSITIVITY1 (MON1), which is important for the fusion of multivesicular bodies to their target membranes. Overexpression of CSEP0162 and silencing of barley MON1 both inhibit encasement formation. We find that the Arabidopsis ecotype No-0 has resistance to powdery mildew, and that this is partially dependent on MON1. Surprisingly, we find the MON1-dependent resistance in No-0 not only includes an encasement response, but also an effective HR. Similarly, silencing of MON1 in barley also blocks Mla3-mediated HR-based powdery mildew resistance. Our results indicate that MON1 is a vital plant immunity component, and we speculate that the barley powdery mildew fungus introduces the effector CSEP0162 to target MON1 and hence reduce encasement formation and HR.
Explosion imminent: the appearance of red supergiants at the point of core-collapse
Authors: Davies Ben , Plez Bertrand , Petrault Mike 
Published: October 2022

ABSTRACT
From the early radiation of type II-P supernovae (SNe), it has been claimed that the majority of their red supergiant (RSG) progenitors are enshrouded by large amounts of circumstellar material (CSM) at the point of explosion. The inferred density of this CSM is orders of magnitude above that seen around RSGs in the field, and is therefore indicative of a short phase of elevated mass-loss prior to explosion. It is not known over what time-scale this material gets there: is it formed over several decades by a ‘superwind’ with mass-loss rate $\dot{M} \sim 10^{-3}\, {\rm M_\odot \, yr^{-1}}$; or is it formed in less than a year by a brief ‘outburst’ with $\dot{M}\sim 10^{-1}\, {\rm M_\odot \, yr^{-1}}$? In this paper, we simulate spectra for RSGs undergoing such mass-loss events, and demonstrate that in either scenario, the CSM suppresses the optical flux by over a factor of 100, and that of the near-IR by a factor of 10. We argue that the ‘superwind’ model can be excluded as it causes the progenitor to be heavily obscured for decades before explosion, and is strongly at odds with observations of II-P progenitors taken within 10 yr of core-collapse. Instead, our results favour abrupt outbursts &lt; 1 yr before explosion as the explanation for the early optical radiation of II-P SNe. We therefore predict that RSGs will undergo dramatic photometric variability in the optical and infrared in the weeks-to-months before core-collapse.