bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in data quality and quality indicators 5 years after implementation of the Dutch Hip Fracture Audit
Authors: Würdemann F. S. , Krijnen P. , van Zwet E. W. , Arends A. J. , Heetveld M. J. , Trappenburg M. C. , Hegeman J. H. , Schipper I. B. ,   The Dutch Hip Fracture Audit Group, Calf A. H. , van Egmond P. W. , van Eijk M. , van Heijl M. , Luyten C. , Schutte B. G. , Voeten S. C. 
Published: June 2022

Abstract
Purpose
The Dutch Hip Fracture Audit (DHFA), a nationwide hip fracture registry in the Netherlands, registers hip fracture patients and aims to improve quality of care since 2016. This study shows trends in the data quality during the first 5 years of data acquisition within the DHFA, as well as trends over time for designated quality indicators (QI).

Methods
All patients registered in the DHFA between 1-1-2016 and 31-12-2020 were included. Data quality-registry case coverage and data completeness-and baseline characteristics are reported. Five QI are analysed: Time to surgery < 48 h, assessment for osteoporosis, orthogeriatric co-management, registration of functional outcomes at three months, 30-day mortality. The independent association between QI results and report year was tested using mixed-effects logistic models and in the case of 30-day mortality adjusted for casemix.

Results
In 2020, the case capture of the DHFA comprised 85% of the Dutch hip fracture patients, 66/68 hospitals participated. The average of missing clinical values was 7.5% in 2016 and 3.2% in 2020. The 3 months follow-up completeness was 36.2% (2016) and 46.8% (2020). The QI ‘time to surgery’ was consistently high, assessment for osteoporosis remained low, orthogeriatric co-management scores increased without significance, registration of functional outcomes improved significantly and 30-day mortality rates remained unchanged.

Conclusion
The DHFA has successfully been implemented in the past five years. Trends show improvement on data quality. Analysis of several QI indicate points of attention. Future perspectives include lowering the burden of registration, whilst improving (registration of) hip fracture patients outcomes.
The local cohomology spectral sequence for topological modular forms
Authors: Bruner Robert , Greenlees John , Rognes John 
Published: June 2022

AbstractWe discuss proofs of local cohomology theorems for topological modular forms, based on Mahowald–Rezk duality and on Gorenstein duality, and then make the associated local cohomology spectral sequences explicit, including their differential patterns and hidden extensions.
Hematologic malignancies following immune checkpoint inhibition for solid tumors
Authors: van Eijs Mick J. M. , van der Wagen Lotte E. , Mous Rogier , Leguit Roos J. , van de Corput Lisette , van Lindert Anne S. R. , Suelmann Britt B. M. , Kamphuis Anna M. , Nierkens Stefan , Suijkerbuijk Karijn P. M. 
Published: June 2022

AbstractImmune checkpoint inhibition (ICI) can induce durable responses in patients with advanced malignancies. Three cases of hematological neoplasia following ICI for solid tumors have been reported to date. We present five patients treated at our tertiary referral center between 2017 and 2021 who developed chronic myeloid leukemia (two patients), acute myeloid leukemia, myelodysplastic syndrome and chronic eosinophilic leukemia during or after anti-PD-1-based treatment. Molecular analyses were performed on pre-ICI samples to identify baseline variants in myeloid genes. We hypothesize that PD-1 blockade might accelerate progression to overt myeloid malignancies and discuss potential underlying mechanisms.
Core body temperatures during final stages of life—an evaluation of data from in-hospital decedents
Authors: Scheidemann Patrick , Schwender Holger , Ritz-Timme Stefanie , Kindgen-Milles Detlef , Hartung Benno 
Published: June 2022

Abstract
Temperature-based methods are widely accepted as the gold standard for death time estimation. In the absence of any other information, the nomogram method generally assumes that a person died with a core body temperature of approximately 37.2 °C. Nevertheless, several external and internal factors may alter the body temperature during agony. A retrospective medical record analysis was carried out on in-hospital death cases from two consecutive years of surgical intensive care units to determine the effects of factors influencing the core body temperature at the point of death. Data from 103 case files were included in the statistical data evaluation. The body temperature fluctuated between and within individuals over time. No clear correlation to certain death groups was observed. Even primary cardiac deaths showed broad intervals of temperatures at the point of death. Men seem to die with higher body temperatures than women. The presented data highlight potential biases for death time estimations when generally assuming a core body temperature of 37.2 °C. In conclusion, the estimation of the time of death should include various methods, including a non-temperature-dependent method. Any uncertainties regarding the body temperature at point of death need to be resolved (e.g. by identifying fever constellations) and elucidated if elimination is not possible.
Recognition of multi-cognitive tasks from EEG signals using EMD methods
Authors: Gupta Akshansh , Kumar Dhirendra , Verma Hanuman , Tanveer M. , Javier Andreu Perez , Lin Chin-Teng , Prasad Mukesh 
Published: June 2022

AbstractMental task classification (MTC), based on the electroencephalography (EEG) signals is a demanding brain–computer interface (BCI). It is independent of all types of muscular activity. MTC-based BCI systems are capable to identify cognitive activity of human. The success of BCI system depends upon the efficient feature representation from raw EEG signals for classification of mental activities. This paper mainly presents on a novel feature representation (formation of most informative features) of the EEG signal for the both, binary as well as multi MTC, using a combination of some statistical, uncertainty and memory- based coefficient. In this work, the feature formation is carried out in the two stages. In the first stage, the signal is split into different oscillatory functions with the help of three well-known empirical mode decomposition (EMD) algorithms, and a new set of eight parameters (features) are calculated from the oscillatory function in the second stage of feature vector construction. Support vector machine (SVM) is used to classify the feature vectors obtained corresponding to the different mental tasks. This study consists the problem formulation of two variants of MTC; two-class and multi-class MTC. The suggested scheme outperforms the existing work for the both types of mental tasks classification.
Stability improvement of laccase for micropollutant removal of pharmaceutical origins from municipal wastewater
Authors: Meiczinger Mónika , Varga Béla , Wolmarans Lana , Hajba László , Somogyi Viola 
Published: June 2022

AbstractMicropollutants are persistent and hazardous materials in low concentrations (ng L−1–μg L−1), including substances such as pharmaceuticals, personal care products and industrial chemicals. The advancement of analytical chemistry has allowed for the detection of micropollutants; however, an efficient and economical treatment solution is yet to be installed. Fungal laccase has been a successful biocatalyst of these compounds. However, large-scale application of free enzyme is currently not feasible for removing water-borne micropollutants, partly due to relatively rapid loss in enzyme stability. In this paper, three types of cyclodextrin, α, β and γCD, were chosen to immobilise the laccase under various conditions with the aim to improve the stability of the enzyme. Laccase activity was chosen as a response parameter, and laccase-cyclodextrin binding was evaluated by Fourier-transform infrared spectroscopy (FTIR). Results showed an optimum using α-cyclodextrin immobilisation. At that level, α-cyclodextrin increased the half-life of laccase and slightly improved its activity in all tested pH by physically bonding to laccase. By protecting the enzyme structure, activity was maintained under a range of circumstances (acidic conditions, from 10 to 50 °C). Under room temperature and at pH 5, α-cyclodextrin-laccase nanocomposite had a better removal efficiency of diclofenac compared to free laccase of the same concentration.
Graphical abstract
Systematic review of health-related quality of life (HRQoL) issues associated with gastric cancer: capturing cross-cultural differences
Authors: Rowsell Alison , Sodergren Samantha C. , Vassiliou Vassilios , Darlington Anne-Sophie , Guren Marianne G. , Alkhaffaf Bilal , Moorbey Chantelle , Dennis Kristopher , Terada Mitsumi 
Published: June 2022

AbstractThe treatment landscape for gastric cancer (GC) is constantly evolving with therapies affecting all aspects of health-related quality of life (HRQoL) which need careful monitoring. While there are HRQoL measures designed specifically to capture issues relevant to patients with GC, these might be outdated and only relevant to patients in westernised cultures. This review identifies the patient-reported measures used to assess HRQoL of patients with GC and compares the HRQoL measures used across cultures including East Asia, where GC is more prevalent. We conducted a systematic review of publications between January 2001 and January 2021. A total of 267 papers were identified; the majority (66%) of studies involved patients from East Asian countries. Out of the 24 HRQoL questionnaires captured, the European Organisation for Research and Treatment of Cancer Core Cancer measure (QLQ-C30) was the most widely used (60% of all studies and 62% of those involving patients from East Asian countries), followed by its gastric cancer-specific module (QLQ-STO22, 34% of all studies and 41% from East Asia). Eight questionnaires were developed within East Asian countries and, of the 20 studies including bespoke questions, 16 were from East Asia. There were six qualitative studies. HRQoL issues captured include diarrhoea, constipation, reflux, abdominal pain and abdominal fulness or bloating, difficulty swallowing, restricted eating, and weight loss. Psychosocial issues related to these problems were also assessed. Issues relating to the compatibility of some of the westernised measures within East Asian cultures were highlighted.
How should we treat long-standing overt ventriculomegaly in adults (LOVA)? A retrospective cohort study
Authors: Gillespie Conor S. , Richardson George E. , Mustafa Mohammad A. , Evans Daisy , George Alan M. , Islim Abdurrahman I. , Mallucci Conor , Jenkinson Michael D. , McMahon Catherine J. 
Published: June 2022

Abstract
Long-standing overt ventriculomegaly in adults (LOVA) is a heterogenous group of conditions with differing presentations. Few studies have evaluated success rates of available surgical treatments, or ascertained the natural history. There is a need to assess the efficacy of both endoscopic third ventriculostomy (ETV) and ventriculoperitoneal shunt (VPS) as first-line treatments. We conducted a retrospective, single-centre study of adults with LOVA at a tertiary neurosurgery centre in England, UK, aiming to identify presentation, management strategy, and outcome following treatment. A total of 127 patients were included (mean age 48.1 years, 61/127 male). Most patients were symptomatic (73.2%, n = 93/127, median symptom duration 10 months). The most common symptoms were gait ataxia, headache, and cognitive decline (52.8%, 50.4%, and 33.9%, respectively). Fourteen patients had papilloedema. Ninety-one patients (71.7%) underwent surgery (84 ETV, 7 VPS). Over a median follow-up of 33.0 months (interquartile range [IQR] 19.0–65.7), 82.4% had a clinical improvement after surgery, and 81.3% had radiological improvement. Clinical improvement rates were similar between ETV and VP shunt groups (82.1% vs 85.7%, p = 0.812). Surgical complication rates were significantly lower in the ETV group than the VP shunt group (4.8% vs 42.9%, p < 0.001). Of the patients treated surgically, 20 (22.0%) underwent further surgery, with 14 patients improving. This study demonstrates the efficacy of ETV as a first-line treatment for LOVA.
Drug loaded cellulose–chitosan aerogel microfibers for wound dressing applications
Authors: Rostamitabar M. , Ghahramani A. , Seide G. , Jockenhoevel S. , Ghazanfari S. 
Published: June 2022

AbstractCellulose and chitosan have been studied for wound dressing due to their biocompatibility, biodegradability, lower antigenicity, and renewability. The functional and structural characteristics of such biopolymers can be dramatically improved by their transformation into fibrous bioaerogels due to their outstanding characteristics such as low density, high porosity, and large specific surface area. Producing aerogels in the form of fibers and textiles not only can enhance mechanical properties, stiffness, and shapeability of aerogels but also lead to short drying times and scalable production processes. Hereby, wet spun chitosan-cellulose aerogel microfibers (CHCLAFs) in two ratios of 1:5 and 1:10 have been produced by supercritical CO2 (scCO2) drying for wound dressing application. The fibers were also loaded with ibuprofen (IBU) through post-treatment scCO2 impregnation. CHCLAF characteristics in terms of morphology, textural properties, thermal stability, mechanical properties, and in vitro assessment such as drug release, antibacterial properties, cytotoxicity, and wound exudate uptake were analyzed and compared to pure cellulose aerogel microfibers (CLF). Blended CHCLAFs showed a low density (~ 0.18 g/cm3), high porosity (~ 85%), and large specific surface area (~ 300 m2/g) with a macro-porous outer shell and a nano-porous inner core. The fibers were transformed into braided meshes that were highly water absorbable (~ 400 wt.%) and bactericidal against escherichia coli and staphylococcus aureus. Furthermore, the fibrous structures showed no cytotoxicity using fibroblast cells, and the hybrid fibers were able to release IBU over 48 h in a sustained manner. The results showed that the CHCLAFs could be used as a promising candidate for wound dressing materials.
Graphical abstract
Dirhodium complex immobilization on modified cellulose for highly selective heterogeneous cyclopropanation reactions
Authors: Rösler Lorenz , Höfler Mark V. , Breitzke Hergen , Wissel Till , Herr Kevin , Heise Henrike , Gutmann Torsten , Buntkowsky Gerd 
Published: June 2022

AbstractA novel, efficient approach for the functionalization of microcrystalline cellulose (MCC) is presented. The as-obtained material allows the immobilization of chiral dirhodium catalysts preserving their enantioselectivity in asymmetric cyclopropanation reactions. As model, microcrystalline cellulose is modified with a polyethylene glycol derived linker, and Rh2(S-DOSP)4 is grafted on the material to produce a heterogeneous catalyst. SEM images at different stages of the immobilization show an unchanging uniform morphology, providing constantly good separation characteristics. The modification of the cellulose material with the polyethylene derived linker and the immobilization process are monitored using DNP enhanced 1H → 13C CP MAS NMR, quantitative 19F MAS NMR, TGA and ICP-OES analysis, confirming the success of the immobilization as well as the stability of bonds between the used linker molecule and the cellulose material. Finally, the evaluation of the produced catalyst is demonstrated in the asymmetric cyclopropanation reaction between styrene and methyl(E)-2-diazo-4-phenylbut-3-enoate showing excellent enantioselectivity with an ee of nearly 90% over a wide temperature range as well as good recyclability characteristics in four consecutive catalysis cycles.
Genetic differentiation of a critically endangered population of the limpet Patella candei candei d’Orbigny, 1840, in the Canary Islands
Authors: Quinteiro Javier , González-Lorenzo Gustavo , Hernández-Reyes Dailo , Quinteiro Lara , Herrera-Pérez Rogelio , Martínez-Barrio Juán , González José Antonio , Rey-Méndez Manuel , González-Henríquez Nieves 
Published: June 2022

AbstractThe adoption of measures to protect the viability of threatened populations should be supported by empirical data identifying appropriate conservation units and management strategies. The global population of the majorera limpet,P. candei candeid’Orbigny, 1840, is restricted to the Macaronesian islands in the NE Atlantic, including near-to-extinct and healthy populations in Fuerteventura and Selvagens, respectively. The taxonomic position, genetic diversity and intra- and interspecific relationships of these populations are unclear, which is hindering the implementation of a recovery plan for the overexploited majorera limpet on Fuerteventura. In this study, ddRAD-based genome scanning was used to overcome the limitations of mitochondrial DNA-based analysis. As a result,P. candei candeiwas genetically differentiated from the closely relatedP. candei crenatafor the first time. Moreover, genetic differentiation was detected betweenP. candei candeisamples from Selvagens and Fuerteventura, indicating that translocations from the healthy Selvagens source population are inadvisable. In conclusion, the majorera limpet requires population-specific management focused on the preservation of exceptional genetic diversity with which to face future environmental challenges.
Evidence About Harm: Dual Status Victim Participant Testimony at the International Criminal Court and the Straitjacketing of Narratives About Suffering
Authors: D’hondt Sigurd , Pérez-León-Acevedo Juan-Pablo , Ferraz de Almeida Fabio , Barrett Elena 
Published: June 2022

AbstractAlthough victims at the International Criminal Court (ICC) are not parties, they can apply to become “victim participants” and may be authorized by an ICC Chamber to directly and orally express their views and concerns in court. Most ICC Trial Chambers, however, have preferred allowing legal representatives of these victim participants to call victims as witnesses to give testimonial evidence about the harm they suffered. Our article focuses on the practical-epistemological challenges that come with forcing accounts of harm into this testimony-format. We draw upon ethnomethodology and conversation analysis to elucidate the discursive techniques by which legal actors in the Ongwen trial manage these challenges. These include eliciting accounts that “exhibit” suffering, posing questions that transform the “inner self” into an object of inquiry, and approaching witnesses as “informal experts”. Furthermore, while questioning related to establishing criminal liability typically proceeds in a granular fashion, testimony-taking about harm is accompanied by a tolerance for extended answers and an orientation to narrativity.
The Simulation and Design of an On-Chip Superconducting Millimetre Filter-Bank Spectrometer
Authors: Robson G. , Anderson A. J. , Barry P. S. , Doyle S. , Karkare K. S. 
Published: June 2022

AbstractSuperconducting on-chip filter banks provide a scalable, space saving solution to create imaging spectrometers at millimetre and submillimetre wavelengths. We present an easy to realise, lithographed superconducting filter design with a high tolerance to fabrication error. Using a capacitively coupled $$\lambda /2$$

λ
/
2

microstrip resonator to define a narrow ($$\lambda /\Delta \lambda = 300$$

λ
/
Δ
λ
=
300

) spectral pass band, the filtered output of a given spectrometer channel directly connects to a lumped-element kinetic inductance detector. We show the tolerance analysis of our design, demonstrating $$<11\%$$

<
11
%

change in filter quality factor to any one realistic fabrication error and a full filter-bank efficiency forecast to be 50% after accounting for fabrication errors and dielectric loss tangent.
Forensic view on two Raspberry Shake burglargrams
Authors: Hinzen Klaus-G. , Krummel Heinrich , Weber Bernd , Fleischer Claus 
Published: June 2022

AbstractA steadily increasing number of citizen seismological stations, often located in populated areas, record a plethora of man-made events. These events are especially of interest, when they are caused by criminal activity or man-made explosions. On 4 December 2021, during an attempted robbery of an automated teller machine (ATM) in Bonn-Röttgen, Germany, the burglars used explosions. The seismic effects of the explosions were recorded with a Raspberry Shake (RS) station at a distance of 580 m from the site. While working on the analysis of this signal, another attack on an ATM on 23 February 2022 in Kürten-Dürscheid was recorded by another RS station, this time at 830-m distance with an instrument that also included an air pressure channel. The seismic signatures of both events indicate similar procedures in both cases whereby a larger explosion was quickly followed a smaller explosion after 21 s and 49 s, respectively. An estimate of the charge weight of the explosions shows that ratios of the strength of the first to second explosion were 21:1 and 9.4:1 in the Röttgen and Dürscheid attacks, respectively.
A ribbon graph derivation of the algebra of functional renormalization for random multi-matrices with multi-trace interactions
Authors: Pérez-Sánchez Carlos I. 
Published: June 2022

AbstractWe focus on functional renormalization for ensembles of several (say $$n\ge 1$$

n
≥
1

) random matrices, whose potentials include multi-traces, to wit, the probability measure contains factors of the form $$ \exp [-\mathrm {Tr}(V_1)\times \cdots \times \mathrm {Tr}(V_k)]$$

exp
[
-
Tr

(

V
1

)

×
⋯
×
Tr

(

V
k

)

]

for certain noncommutative polynomials $$V_1,\ldots ,V_k\in {\mathbb {C}}_{\langle n \rangle }$$

V
1

,
…
,

V
k

∈

C

⟨
n
⟩

in the n matrices. This article shows how the “algebra of functional renormalization”—that is, the structure that makes the renormalization flow equation computable—is derived from ribbon graphs, only by requiring the one-loop structure that such equation (due to Wetterich) is expected to have. Whenever it is possible to compute the renormalization flow in terms of $$\mathrm U(N)$$

U
(
N
)

-invariants, the structure gained is the matrix algebra $$M_n( \mathcal {A}_{n,N}, \star ) $$

M
n

(

A

n
,
N

,
⋆
)

with entries in $$\mathcal {A}_{n,N}=({\mathbb {C}}_{\langle n \rangle } \otimes {\mathbb {C}}_{\langle n \rangle } )\oplus ( {\mathbb {C}}_{\langle n \rangle } \boxtimes {\mathbb {C}}_{\langle n \rangle })$$

A

n
,
N

=

(

C

⟨
n
⟩

⊗

C

⟨
n
⟩

)

⊕

(

C

⟨
n
⟩

⊠

C

⟨
n
⟩

)

, being $${\mathbb {C}}_{\langle n \rangle } $$

C

⟨
n
⟩

the free algebra generated by the n Hermitian matrices of size N (the flowing random variables) with multiplication of homogeneous elements in $$\mathcal {A}_{n,N}$$

A

n
,
N

given, for each $$P,Q,U,W\in {\mathbb {C}}_{\langle n \rangle }$$

P
,
Q
,
U
,
W
∈

C

⟨
n
⟩

, by $$\begin{aligned} (U \otimes W) \star ( P\otimes Q)&= PU \otimes WQ \,, \\ (U\boxtimes W) \star ( P\otimes Q)&=U \boxtimes PWQ \,, \\ (U \otimes W) \star ( P\boxtimes Q)&= WPU \boxtimes Q \,, \\ (U\boxtimes W) \star ( P\boxtimes Q)&= \mathrm {Tr} (WP) U\boxtimes Q \,, \end{aligned}$$

(
U
⊗
W
)
⋆
(
P
⊗
Q
)

=
P
U
⊗
W
Q

,

(
U
⊠
W
)
⋆
(
P
⊗
Q
)

=
U
⊠
P
W
Q

,

(
U
⊗
W
)
⋆
(
P
⊠
Q
)

=
W
P
U
⊠
Q

,

(
U
⊠
W
)
⋆
(
P
⊠
Q
)

=
Tr
(
W
P
)
U
⊠
Q

,

which, together with the condition $$(\lambda U) \boxtimes W = U\boxtimes (\lambda W) $$

(
λ
U
)
⊠
W
=
U
⊠
(
λ
W
)

for each complex $$\lambda $$
λ
, fully define the symbol $$\boxtimes $$
⊠
.