bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liposome‐Mediated Biomimetic Delivery of PLK3 Inhibitor with NIR II‐Triggered Release Prevents Renal Ischemia‐Reperfusion Injury
Authors: Zhu Dongdong , Zhang Hailing , Li Junhui , Qian Xiaoqian , Guo Meng , Jiang Gengru , Gu Yan 
Published: September 2022

AbstractAs one of the leading causes of acute kidney injury (AKI), ischemia‐reperfusion injury (IRI) results in tubular necrosis and renal inflammation. Here, from gene screening, it is found that Polo‐like kinase 3 (PLK3), but not other PLKs, is highly up‐regulated during mouse IRI. In vivo administration of PLK3 inhibitor alleviates IRI‐induced AKI, but induces myelosuppression. Thus, a novel liposome‐mediated biomimetic delivery system with 1080 nm near infrared (NIR)‐triggered release to specifically and efficiently delivering the inhibitor to the kidney is developed. NIR light irradiation to kidney results in an excellent effect for reduced immune cell infiltration and renal inflammation. Mechanistically, PLK3 inhibition suppresses the degradation of hypoxia‐inducible factor‐1α (HIF‐1α) and reactive oxygen species (ROS)‐mediated oxidative stress, thus protecting the renal tubular epithelial cells from cell death and preventing macrophage activation and renal inflammation. Thus, the NIR light‐triggered liposome system provides an efficient candidate treatment for AKI without systemic side effect.
Cell‐Free, Dendritic Cell‐Mimicking Extracellular Blebs for Molecularly Controlled Vaccination
Authors: Thone Melissa N. , Chung Jee Young , Ingato Dominique , Lugin Margaret L. , Kwon Young Jik 
Published: September 2022

AbstractDendritic cells (DCs) are prime targets for vaccination and immunotherapy. However, limited control over antigen presentation at a desired maturation status in these plastic materials remains a fundamental challenge in efficiently orchestrating a controlled immune response. DC‐derived extracellular vesicles (EVs) can overcome some of these issues, but have significant production challenges. Herein, this work employs a unique chemicallyinduced method for production of DC‐derived extracellular blebs (DC‐EBs) that overcome the barriers of DC and DC‐derived EV vaccines. DC‐EBs are molecular snapshots of DCs in time, cell‐like particles with fixed stimulatory profiles for controlled immune signaling. DC‐EBs are produced in an order of magnitude more quickly and efficiently than conventional EVs and display stable structural integrity and antigen presentation compared to live DCs. Multi‐omic analysis confirmed DC‐EBs are majorly pure plasma membrane vesicles that are homogeneous at the single‐vesicle level, critical for safe and effective vaccination. Immature versus mature molecular profiles on DC‐EBs exhibit molecularly modulated immune responses compared to live DCs, improving remission and survival of tumor‐challenged mice via generation of antigen‐specific T cells. For the first time, DC‐EBs make their case for use in vaccines and for their potential in modulating other immune responses, potentially in combination with other immunotherapeutics.
Differential prognostic impact of RUNX1 mutations according to frontline therapy in patients with acute myeloid leukemia
Authors: Venugopal Sangeetha , DiNardo Courtney D. , Loghavi Sanam , Qiao Wei , Ravandi Farhad , Konopleva Marina , Kadia Tapan , Bhalla Kapil , Jabbour Elias , Issa Ghayas C. , Macaron Walid , Daver Naval , Borthakur Gautam , Montalban‐Bravo Guillermo , Yilmaz Musa , Patel Keyur P. , Kanagal‐Shamanna Rashmi , Chien Kelly , Maiti Abhishek , Kantarjian Hagop , Short Nicholas J. 
Published: September 2022

AbstractRUNX1‐mutated (mRUNX1) acute myeloid leukemia (AML) has historically been associated with poor outcomes in the setting of conventional chemotherapy. The prognostic impact of mRUNX1 AML is not well‐established in the current era of lower‐intensity treatment regimens incorporating venetoclax. We retrospectively analyzed 907 patients with newly diagnosed AML, including 137 patients with mRUNX1 AML, who underwent first‐line therapy with intensive chemotherapy (IC), low‐intensity therapy without venetoclax (LIT without VEN), or LIT with VEN. When stratified by RUNX1 status, there was no statistically significant difference in outcomes between mRUNX1 and wild‐type (wtRUNX1) AML, regardless of therapy received. However, among patients who received LIT with VEN, there was a trend towards superior overall survival (OS) in those with mRUNX1 AML (median OS for mRUNX1 vs. wtRUNX1: 25.1 vs. 11.3 months; 2‐year OS 54% vs. 33%; p = 0.12). In patients without another adverse‐risk cyto‐molecular feature, the presence of mRUNX1 conferred inferior OS in patients who received IC (p = 0.02) or LIT without VEN (p = 0.003) but not in those who received LIT with VEN (mRUNX1 vs. wtRUNX1: 25.1 vs. 30.0 months; 2‐year OS 59% vs. 54%; p = 0.86). A multivariate analysis showed possible interaction between RUNX1 mutation status and treatment, suggesting a differential prognostic impact of RUNX1 mutations when patients received IC versus LIT with VEN. In summary, the prognostic impact of mRUNX1 AML may be treatment‐dependent, and the presence of RUNX1 mutations may not impact clinical outcomes when venetoclax‐based regimens are used.
Clinical significance of clonal hematopoiesis in the setting of autologous stem cell transplantation for lymphoma
Authors: Lackraj Tracy , Ben Barouch Sharon , Medeiros Jessie J. F. , Pedersen Stephanie , Danesh Arnavaz , Bakhtiari Mehran , Hong Michael , Tong Kit , Joynt Jesse , Arruda Andrea , Minden Mark D. , Kuruvilla John , Bhella Sita , Kukreti Vishal , Crump Michael , Prica Anca , Chen Christine , Deng Yangqing , Xu Wei , Pugh Trevor J. , Keating Armand , Dick John E. , Abelson Sagi , Kridel Robert 
Published: September 2022

AbstractAutologous stem cell transplantation (ASCT) remains a key therapeutic strategy for treating patients with relapsed or refractory non‐Hodgkin and Hodgkin lymphoma. Clonal hematopoiesis (CH) has been proposed as a major contributor not only to the development of therapy‐related myeloid neoplasms but also to inferior overall survival (OS) in patients who had undergone ASCT. Herein, we aimed to investigate the prognostic implications of CH after ASCT in a cohort of 420 lymphoma patients using ultra‐deep, highly sensitive error‐correction sequencing. CH was identified in the stem cell product samples of 181 patients (43.1%) and was most common in those with T‐cell lymphoma (72.2%). The presence of CH was associated with a longer time to neutrophil and platelet recovery. Moreover, patients with evidence of CH had inferior 5‐year OS from the time of first relapse (39.4% vs. 45.8%, p = .043) and from the time of ASCT (51.8% vs. 59.3%, p = .018). The adverse prognostic impact of CH was not due to therapy‐related myeloid neoplasms, the incidence of which was low in our cohort (10‐year cumulative incidence of 3.3% vs. 3.0% in those with and without CH, p = .445). In terms of specific‐gene mutations, adverse OS was mostly associated with PPM1D mutations (hazard ratio (HR) 1.74, 95% confidence interval (CI) 1.13–2.67, p = .011). In summary, we found that CH is associated with an increased risk of non‐lymphoma‐related death after ASCT, which suggests that lymphoma survivors with CH may need intensified surveillance strategies to prevent and treat late complications.
Proximal urea cycle defects are challenging to detect with newborn screening: Results of a prospective pilot study using post‐analytical tools
Authors: Hall Patricia Liane , Wittenauer Angela Lynn , Wilcox William Ross 
Published: September 2022

AbstractThe purpose of this pilot project was to evaluate the efficacy of the Collaborative Integrated Laboratory Reports (CLIR) postanalytical tools from Mayo Clinic for detection of newborns with proximal urea cycle disorders (PUCD) in the Georgia newborn screening program that uses the underivatized Neobase2 kit (Perkin Elmer). We evaluated 138,560 newborn screening (NBS) samples (between 125,000 and 130,000 children) and used the CLIR result interpretation guidelines to stratify results. Children at higher risk of having a PUCD received follow‐up services including confirmatory lab testing (ammonia, plasma amino acids, urine orotic acid) or a repeat NBS sample. We made multiple adjustments to our CLIR PUCD tool and to our follow‐up algorithms in order to reduce false positives. Regardless, a high number of NBS samples resulted with false positives in part due to the glutamine peak also containing lysine. No children were diagnosed with a PUCD during our study period, and the Emory Genetics Metabolic Center is unaware of any children diagnosed outside of the NBS system during that time. Based on our experience, PUCD is not suitable for statewide NBS using Neobase2 and CLIR. Other methodologies that can separate glutamine from other amino acids may have better performance.
Biomarkers for dementia in Latin American countries: Gaps and opportunities
Authors: Parra Mario A. , Orellana Paulina , Leon Tomas , Victoria Cabello G. , Henriquez Fernando , Gomez Rodrigo , Avalos Constanza , Damian Andres , Slachevsky Andrea , Ibañez Agustin , Zetterberg Henrik , Tijms Betty M. , Yokoyama Jennifer S. , Piña‐Escudero Stefanie D. , Cochran J. Nicholas , Matallana Diana L. , Acosta Daisy , Allegri Ricardo , Arias‐Suárez Bianca P. , Barra Bernardo , Behrens Maria Isabel , Brucki Sonia M. D. , Busatto Geraldo , Caramelli Paulo , Castro‐Suarez Sheila , Contreras Valeria , Custodio Nilton , Dansilio Sergio , la Cruz‐Puebla Myriam De , de Souza Leonardo Cruz , Diaz Monica M. , Duque Lissette , Farías Gonzalo A. , Ferreira Sergio T. , Guimet Nahuel Magrath , Kmaid Ana , Lira David , Lopera Francisco , Meza Beatriz Mar , Miotto Eliane C. , Nitrini Ricardo , Nuñez Alberto , O'Neill Santiago , Ochoa John , Pintado‐Caipa Maritza , Resende Elisa de Paula França , Risacher Shannon , Rojas Luz Angela , Sabaj Valentina , Schilling Lucas , Sellek Allis F. , Sosa Ana , Takada Leonel T. , Teixeira Antonio L. , Unaucho‐Pilalumbo Martha , Duran‐Aniotz Claudia 
Published: September 2022

AbstractLimited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.
Synthesis and Upper Bound of Schmidt Rank of Bipartite Controlled‐Unitary Gates
Authors: Jiang Gui‐Long , Wei Hai‐Rui , Song Guo‐Zhu , Hua Ming 
Published: September 2022

AbstractQuantum circuit model is the most popular paradigm for implementing complex quantum computation. Based on Cartan decomposition, it is shown generalized controlled‐X (GCX) gates, 6 single‐qubit rotations about the y‐ and z‐axes, and single‐partite y‐ and z‐rotation‐types which are defined in this paper are sufficient to simulate a controlled‐unitary gate with controlling on . In the scenario of the unitary gate with that is locally equivalent to a diagonal unitary on , GCX gates and single‐partite y‐ and z‐rotation‐types are required to simulate it. The quantum circuit for implementing and are presented. Furthermore, it is found that with controlling has Schmidt rank two, and in other cases the diagonalized form of the target unitaries can be expanded in terms of specific simple types of product unitary operators.
Substrate Tumbling in a Chemisorbed Diastereomeric α‐Ketoester/1‐(1‐Naphthyl)ethylamine Complex
Authors: Dong Yi , Lemay Jean‐Christian , Zeng Yang , Groves Michael N. , McBreen Peter H. 
Published: September 2022

AbstractScanning tunneling microscopy (STM) data for α‐ketoester/1‐(1‐naphthyl)ethylamine complexes on Pt(111) reveal a tumbling motion that couples two neighboring binding states. The interconversion, resulting in prochiral inversion of the α‐ketoester, occurs in single complexes without breaking them apart. This is a surprising observation because the overall motion requires rotation of the α‐ketoester away from the surface without branching exclusively into diffusion away from the complex or desorption. The multi‐step interconversion is rationalized in terms of sequences of bound states that combine transient H‐bond interactions with the chiral molecule and weakened adsorption interactions with the metal. The observation of tumbling in single long‐lived complexes is of relevance to self‐assembly and directed molecular motion on surfaces, to ligand‐controlled surface reactions, and most directly to stereocontrol in asymmetric heterogeneous catalysis.
C(sp3)−H Hydroxylation in Diiron β‐Hydroxylase CmlA Transpires by Amine‐Assisted O2 Activation Avoiding FeIV2O2 Species
Authors: Lu Jiarui , Lai Wenzhen , Chen Hui 
Published: September 2022

AbstractThrough QM/MM modeling, we discovered that C(sp3)−H β‐hydroxylation in the diiron hydroxylase CmlA transpires by traceless amine‐assisted O2 activation. Different from the canonical diiron hydroxylase sMMO, this aliphatic‐amine‐assisted O2 activation avoids generating the high‐valent diferryl FeIV2O2 species, but alternatively renders a diferric FeIII2O species as the reactive oxidant. From this unprecedented O2 activation mode, the derived C(sp3)−H hydroxylation mechanism in CmlA also differs drastically from the toluene aromatic C(sp2)−H hydroxylation in the diiron hydroxylase T4MO. This substrate‐modulated O2 activation in CmlA has rich mechanistic implications for other diiron hydroxylases with an amine group adjacent to the C−H bond under hydroxylation in substrates, such as hDOHH. Furthermore, the adapted coordination environment of the diiron cofactor upon O2 binding in CmlA opens up more structural and mechanistic possibilities for O2 activation in non‐heme diiron enzymes.
Atroposelective Access to 1,3‐Oxazepine‐Containing Bridged Biaryls via Carbene‐Catalyzed Desymmetrization of Imines
Authors: Yang Xing , Wei Liwen , Wu Yuelin , Zhou Liejin , Zhang Xinglong , Chi Yonggui Robin 
Published: September 2022

AbstractWe disclose herein an atroposelective synthesis of novel bridged biaryls containing medium‐sized rings via N‐heterocyclic carbene organocatalysis. The reaction starts with addition of the carbene catalyst to the aminophenol‐derived aldimine substrate. Subsequent oxidation and intramolecular desymmetrization lead to the formation of 1,3‐oxazepine‐containing bridged biaryls in good yields and excellent enantioselectivities. These novel bridged biaryl products can be readily transformed into chiral phosphite ligands. Preliminary density function theory calculations suggest that the origin of enantioselectivity arises from the more favorable frontier molecular orbital interactions in the transition state leading to the major product.
A Bifunctional CdS/MoO2/MoS2 Catalyst Enhances Photocatalytic H2 Evolution and Pyruvic Acid Synthesis
Authors: Bie Chuanbiao , Zhu Bicheng , Wang Linxi , Yu Huogen , Jiang Chenhui , Chen Tao , Yu Jiaguo 
Published: September 2022

AbstractThe best use of photogenerated electrons and holes is crucial to boosting photocatalytic activity. Herein, a bifunctional dual‐cocatalyst‐modified photocatalyst is constructed based on CdS/MoO2/MoS2 hollow spheres for hydrogen evolution coupled with selective pyruvic acid (PA) production from lactic acid (LA) oxidation. MoS2 and MoO2 are simultaneously obtained from the conversion of CdMoO4 in one step. In a photocatalytic process, the MoS2 and MoO2 function as the reduction and oxidation centers on which photogenerated electrons and holes accumulate and are used for hydrogen evolution reaction (HER) and PA synthesis, respectively. By monitoring the intermediates, a two‐step single‐electron route for PA production is proposed, initiated by the cleavage of the α‐C(sp3)−H bond in the LA. The conversion of LA and the selectivity of PA can reach ca. 29 % and 95 % after a five‐hour reaction, respectively.
Copper‐amine complex immobilized on nano NaY zeolite as a recyclable nanocatalyst for the environmentally friendly synthesis of 2‐amino‐4H‐chromenes
Authors: Azizi Amiri Mohammadreza , Pasha Ghasem Firouzzadeh , Tajbakhsh Mahmood , Asghari Sakineh 
Published: September 2022

The nano NaY zeolite‐supported copper‐amine complex was prepared by postmodification of the nano NaY zeolite with 3‐chloropropyl trimethoxysilane (CPTMS) and [2‐({3‐[(2‐aminoethyl)thio]propyl}thio)ethyl]amine followed by coordination with Cu (I) ion. Various techniques such as Fourier transform infrared spectroscopy (FT‐IR), X‐ray powder diffraction (XRD), dynamic light scattering (DLS), thermogravimetric analysis (TGA), differential thermal analysis (DTA), scanning electron micrograph (SEM), transmission electron microscopy (TEM), Brunauer–Emmett–Teller (BET), t‐plot, energy dispersive spectroscopy (EDS), inductively coupled plasma (ICP), and elemental analyses were used to characterize the structure of the synthesized catalyst. The catalytic activity of the synthesized nano‐sample was evaluated in a three‐component synthesis of 2‐amino‐4H‐chromene derivatives, which resulted in high reaction yields and short reaction times under green conditions. The catalyst is separated by filtration and can be reused for at least seven consecutive runs without significant loss of catalytic activity. The nature of the supported [2‐({3‐[(2‐aminoethyl)thio]propyl}thio)ethyl]amine (NN) on the zeolite's surface improved the catalytic activity of the zeolite, provided homogeneity to the catalyst, and enhanced the capability of coordination with copper ions. Facile catalyst recovery and reuse, simple setup procedure and generality of the method, high turnover number (TON), and aqueous ethanol as a green solvent make this procedure an environmentally benign approach for preparing the titled heterocycles. The findings in this work revealed that the introduced catalytic system could be used to prepare other beneficial heterocyclic compounds under environmentally benign conditions.
Long‐term monitoring shows that drought sensitivity and riparian land use change coincide with freshwater mussel declines
Authors: Lopez Jonathan W. , DuBose Traci P. , Franzen Alex J. , Atkinson Carla L. , Vaughn Caryn C. 
Published: September 2022

Abstract

Freshwater mussels (Bivalvia: Unionoida) are globally imperilled and are the subjects of wide‐ranging conservation initiatives. This study combined traditional species‐monitoring surveys with a novel functional trait classification scheme and publicly available environmental data to assess potential environmental drivers of declining mussel abundance and species richness.
Surveys to document mussel abundance and assemblage composition in south‐east Oklahoma, United States were conducted on the Glover, Mountain Fork and upper Little rivers. Present day survey results (2015–2021) were compared with those from previous studies (1993–1999, 2010) to document long‐term changes in the species and functional composition of mussel assemblages and concurrent changes in climate and land use.
Mussel catch per unit effort declined by 71.5% between historical and present day surveys. Species richness declined by 44.4% over this same period. Using a novel classification of mussel drought sensitivity, it was found that the declines were associated with a disproportionate loss of drought‐sensitive taxa (67.0% decline) – those classified as drought‐tolerant did not decline in abundance. Mussel declines coincided with the loss of open surface waters (such as streams, ponds and lakes) and riparian wetlands, increased local air temperatures and longer and more intense hydrological drought.
These findings indicate that for a complete understanding of the causes and consequences of mussel declines, conservation biologists must not only monitor the species composition and abundance of threatened organisms, but also consider functional traits. The results further underscore the importance of long‐term monitoring for long‐lived organisms owing to the decadal time scales over which climate and land use change occur.
Parasympathetic withdrawal indexes risk for emotion dysregulation in children with autism spectrum disorder
Authors: Baker Jason K. , Fenning Rachel M. , Erath Stephen A. , Fabian Sarah 
Published: September 2022

AbstractChildren with autism spectrum disorder (ASD) experience significant difficulties with emotion regulation. Theory and empirical evidence suggest substantial biological contributions to regulatory challenges, which may be related to core ASD symptoms. Respiratory sinus arrythmia (RSA) is a measure of parasympathetic nervous system activity that serves as a putative biomarker for emotion regulation. Higher baseline RSA and more RSA reactivity (parasympathetic withdrawal; RSA‐R) in response to challenge appear adaptive in non‐clinical populations, but existing evidence for children with ASD remains inconclusive. The current study examined correlates of observed emotion dysregulation in 61 children with ASD between the ages of 6 and 10 years, including ASD symptom levels as well as both baseline RSA and concurrent RSA reactivity. Consistent with previous research, ASD symptom level was significantly correlated with observed dysregulation whereas additional factors such as child IQ were not. Baseline RSA was unrelated to observed dysregulation, but higher RSA reactivity predicted concurrent dysregulation above and beyond the contribution of child ASD symptoms. Findings contribute to an emerging understanding of dysregulation in these children, raise questions about the utility of traditional baseline RSA measures for this population, and clarify the functional significance of RSA reactivity as a risk factor for emotion dysregulation in children with ASD.
Ambiphilic singlet carbenes: Electron donors and acceptors
Authors: Kim Hyunho , Lee Eunsung 
Published: September 2022

AbstractThe isolation of cyclic(alkyl)(amino)carbenes (CAACs) and N,N′‐diamidocarbenes (DACs) has opened up new avenues in the field of carbene chemistry due to their unique properties. CAACs are strong σ‐donors and π‐acceptors, whereas DACs are extremely strong π‐acceptors. The ambiphilicity of carbenes can facilitate new applications such as small molecule activation and catalysis. Since the isolation of CAACs and DACs, several new ambiphilic carbenes have been synthesized, thereby advancing the development of carbene chemistry. This review summarizes the most relevant findings on ambiphilic carbene chemistry until 2022.