bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of object analysis with data classification in confidence order
Authors: Pradeep M. 
Published: August 2022

Abstract
Object analysis with the detection of an image, in order to specify the classification might be distributed in the coordinate order for rendering the data movement in the order distributed from the classified image. To distribute the image variable in an coordinate sequence that acquire the order to be achieved in the refinement of data that attain the image, with the distribution order that render the sequence in movement from the other object. Object with the classification order that position the movement with the coordinate relation that distribute the movement order with the image that is notated for classification. With the image that classify the model under the distribution data that analyze the order, with the relation mapped in the specific coordinates, the image that order the function in relation with the coordinate that analyze the image in position from the order. Image that analyze the model under distribution for the order mapped into function. In the Existing system with the use of different probabilistic features to calculate the uncertainity data image in computation. In our Proposed model might require the huge integration of a analyzed image data in the probabilistic data in the order metric
Application of robot-assisted endoscopic technique in the treatment of patent ductus arteriosus in 106 children
Authors: Ying Liyang , Wang Xueke , Liu Xiwang , Tan Zheng , Yu Jiangen , Yang Lijun , Shu Qiang 
Published: August 2022

Abstract
Objective
To evaluate and apply the robot-assisted endoscopic surgical technique for treatment of patent ductus arteriosus (PDA) in children.
Methods
Clinical data of 106 children with PDA who underwent robot-assisted endoscopic operation were retrospectively analyzed from August, 2020 to March, 2022. Demographic and preoperative data were collected, including the patient’s age, weight, diameter of the ductus arteriosus, operation time, length of postoperative hospital stay, postoperative complications and hospitalization cost. The age ranged from 6 months to 12 years with median age of 2.5 years. And the weight ranged from 6.6 kilograms (kg) to 51.6 kg with median weight of 12.5 kg. Patients who received transcatheter PDA closure were also enrolled during the same period. Clinical features and perioperative data were compared between the two groups.
Results
All the 106 cases underwent robotically assisted surgery for PDA ligation. No one was converted to thoracotomy. The length of operation time was 15–84 minutes, with an average of 39.4 minutes. There was no obvious bleeding during the operation. The length of postoperative hospital stays were 1–3 days, with an average of 1.1 ± 0.2 days, which was significantly shorter than that of patients underwent transcatheter approach PDA closure (2.2 ± 0.2 days) (p < 0.05). The average hospitalization costs were US$ 8180 in the 106 patients, which were more expensive than that of ones who received transcatheter procedure (US$ 5076 ± 406) (p < 0.05). Only one case was found to have residual ductus shunt during early postoperative follow-up. One case was found with recurrent laryngeal nerve injury. All the two cases were recovery after 3 months of follow-up. The median duration of follow-up were 12 (1–20) months. No other short-term complications occurred during the follow-up period.
Conclusion
Robotic surgical technique for PDA ligation in children is a safe, effective and reliable surgical method with less trauma, faster recovery and fewer surgical risks. This approach should be considered as an option in children patients requiring PDA ligation.
Machine learning models predict overall survival and progression free survival of non-surgical esophageal cancer patients with chemoradiotherapy based on CT image radiomics signatures
Authors: Cui Yongbin , Li Zhengjiang , Xiang Mingyue , Han Dali , Yin Yong , Ma Changsheng 
Published: August 2022

Abstract
Purpose: To construct machine learning models for predicting progression free survival (PFS) and overall survival (OS) with esophageal squamous cell carcinoma (ESCC) patients. Methods: 204 ESCC patients were randomly divided into training cohort (n=143) and validation cohort (n=61) according to the ratio of 7:3. Two radiomics models were constructed by features which were selected by LASSO Cox model to predict PFS and OS, respectively. Clinical features were selected by univariate and multivariate Cox proportional hazards model (p<0.05). Combined radiomics and clinical model was developed by selected clinical and radiomics features. The receiver operating characteristic (ROC) curve, Kaplan Meier (KM) curve and nomogram were used to display the capability of constructed models. Results: There were 944 radiomics features extracted based on region of interest (ROI) in CT images. There were six radiomics features and seven clinical features for PFS prediction and three radiomics features and three clinical features for OS prediction; The radiomics models showed general performance in training cohort and validation cohort for prediction for prediction PFS (AUC, 0.664, 0.676. C-index, 0.65, 0.64) and OS (AUC, 0.634, 0.646.C-index, 0.64, 0.65). The combined models displayed high performance in training cohort and validation cohort for prediction PFS (AUC, 0.856, 0.833. C-index, 0.81, 0.79) and OS (AUC, 0.742, 0.768. C-index, 0.72, 0.71) Conclusion: We developed combined radiomics and clinical machine learning models with better performance than radiomics or clinical alone, which were used to accurate predict 3 years PFS and OS of non-surgical ESCC patients. The prediction results could provide a reference for clinical decision.
Development and validation of a novel HER2RI assay for predicting the risk of recurrence and survival in HER2-positive early breast cancer
Authors: Kang Yikun , Chen Keyu , Gao Singlin , Wang Xiaojia , Wang Xue , Yue Jian , Wang Ouchen , Li Jianmin , Wang Huimin , Chen Tinghao , Du Furong , Cao Shangzhi , Xu Binghe , Yuan Peng 
Published: August 2022

Abstract

De-escalated or escalated systemic therapy remains to be a controversial topic for HER2-positive early breast cancer. Here we presented a novel assay for predicting the relapse risk and survival in HER2-positive early breast cancer. The prognostic models based on the 20-gene signature (HER2RI model) and 20-gene signature combined with nodal stage (HER2RIclin model) were built using random forest, respectively. Totally 254 patients were used for training the models, and two independent cohorts for validating the accuracy. The HER2RI presented a better predictive accuracy than the HER2RIclin. Compared with high-risk patients, the low-risk patients stratified by the HER2RI showed a better 7-year relapse-free survival (RFS) rate. Multivariate analysis further confirmed the high risk stratified by the HER2RI was a significant risk factor for RFS. Overall, the HER2RI assay is predictive of the relapse risk in HER2-positive early breast cancer and can help the patient risk stratification to aid the treatment decisions.
Exercise induced Brugada Pattern and Ventricular Tachycardia during Capecitabine Treatment
Authors: Strobel George , Ponamgi Shiva P. , Roka Attila , Aboeata Ahmed SA 
Published: August 2022

Abstract
We report the case of a 59-year-old female patient with no previous cardiovascular disease treated for Breast cancer with Capecitabine. Shortly after starting treatment, she developed recurrent angina. An exercise stress echocardiogram was performed, which induced a type 1 Brugada pattern twelve seconds of a non-sustained pleomorphic ventricular tachycardia ensued.
Sequences behavior and applications
Authors: Drissi Driss 
Published: August 2022

Abstract
Let j be a fixed integer. Let {xn} be a sequence of complex numbers and let ∆xj = xj+1 -xj. Let 0 < α < 1, first, it is shown that (a) |xn| = O(eϵnα) as n → ∞ for all ϵ > 0, and (b) |Δnxj |1/n→ 0 as n → ∞, if and only if there exists a positive constant R such that ||Δnxj || ≤ Rnnn(1- 1/a). Second, we present an extended version of our result [3], where the condition on the growth of the sequence is replaced by the same condition on the Cesaro means Mn(xn) and retaining the conclusion. Applications to the orbits of operators are given.This helps to elucidate and improve former results of Mbekhta-Zemánek, Atzmon
Using Multiple Choice Questions to Evaluate the Difficulty and Long-Term Retention of Factual Versus Conceptual Knowledge
Authors: Haycocks Neil G. , Hernandez-Moreno Jessica , Bester Johan C. , Hernandez Robert , Kalili Rosalie , Samrao Daman , Simanton Edward , Vida Thomas A. 
Published: August 2022

Abstract
Multiple choice questions (MCQs) are the mainstay of examinations for medical education, physician licensing, and board certification. MCQs are traditionally a preferred way to test rote recall of memorized facts. Their utility in assessing higher cognitive functions has been more problematic to determine. We classified a series of 43 MCQs into two groups to test recall/verbatim thinking and conceptual/inferential thinking, respectively. The MCQs were used to test two related hypotheses 1) scores for recall/verbatim questions would be significantly higher than scores for inferential questions and 2) memory loss would be more rapid for factual minutiae compared to loss in the ability to critically reason about concepts. The MCQs were first used on a summative exam in 2020, which served as a retrospective benchmark of their performance characteristics. The same questions were readministered to volunteers (n = 56) from the same cohort of students in 2022. Retrospective analysis showed the recall/verbatim questions were indeed answered correctly more often than the concept/inference questions (82.0% vs. 60.9%, P = 0.002). Per quartile, only the concept/inference questions showed a significant decline in performance. Two years later, the performance decline was significant for recall/verbatim questions (P < 0.001) but not concept/inference questions (P = 0.050). Analysis of subgroups showed a general convergence of performance on both question types, indicating regression to a baseline mean that may be influenced by the clinical applicability of the material. These findings suggest that conceptual/inferential thinking is more difficult than rote memorization, but the knowledge acquired is more durable, especially if it is reinforced in clinical settings.
Pathological and oncological outcomes of pylorus-preserving versus conventional distal gastrectomy in early gastric cancer: A systematic review and meta-analysis
Authors: Hou Sen , Liu Fan , Gao Zhidong , Ye Yingjiang 
Published: August 2022

Abstract
Background: Pylorus-preserving gastrectomy (PPG) is a function-preserving surgery for the treatment of early gastric cancer (EGC) in the middle third of the stomach. According to the literature reports, PPG decreased decreases the incidence of dumping syndrome, bile reflux, gallstone formation, and nutritional deficit in comparisoned with conventional distal gastrectomy (CDG). However, the debates about PPG has have been dominated by the incomplete lymphadenectomy and oncological safety. We carried out a systematic review and meta-analysis to evaluate the pathological and oncological outcomes of PPG.Methods: The protocol was registered in PROSPERO under number CRD42022304677. Databases including PubMed, Embase, Web of science Science and the Cochrane Register of Controlled Trials were searched before February 21,2022. The outcomes included the pooled odds ratios (ORs) for dichotomous variables and weighted mean differences (WMDs) for continuous variables. For Aall outcomes, were 95% calculated with 95% confidence intervals (CiCIs) were calculated. Meta-analysis was performed using STATA software (Stata 14, Stata Corporation, Texas) and Review Manager 5.4. Results: A total of 4500 patients from 16 studies were included. Compared with the CDG group, the PPG group has had less fewer lymph nodes harvested (WMD=-3.09; 95% CI -4.75 to -1.43; P<0.001). Differences of in the number of resected lymph nodes were observed in at stations No.5, No.6, No.9 and No.11p stations. There were no differences in lymph nodes metastasis of at each station. Shorter proximal resection margins (WMD= -0.554; 95% CI, -0.999 to -0.108; P=0.015) and distal resection margins (WMD= -1.569; 95% CI -3.132 to -0.007; P=0.049) were observed in the PPG group. There were no significant differences in pathological T1a stage (OR=0.99; 95% CI 0.80 to 1.23; P=0.88), T1b stage (OR=1.01; 95% CI 0.81 to 1.26; P=0.88), N0 stage (OR=0.97; 95% CI 0.63 to 1.48; P=0.88), tumor size (WMD = -0.10; 95% CI, -0.25 to 0.05; P = 0.187), differentiated carcinoma (OR=1.04; 95% CI 0.74 to 1.47; P=0.812) or signet ring cell carcinoma (OR=1.22; 95% CI 0.90 to 1.64; P=0.198). No significant differences were observed between the groups in terms of overall survival (HR=0.63; 95% CI 0.24 to 1.67; P=0.852HR=0.22 95%CI 0.01 to 6.69; P=1.000) and or recurrence recurrence-free survival (HR=0.29; 95% CI 0.03 to 2.67; P=0.900HR=0.31; 95%CI 0.00 to 24.35; P=0.687)..Conclusions: The meta-analysis of existing evidence demonstrated that PPG the survival outcomes of PPG may be had comparable survival outcomes withto those of CDG. However, PPG harvested lessfewer lymph nodes at stations in No. 5, No. 6, No. 9 and No. 11p were harvested with PPG stations. We also found that PPG has shorter proximal resection margins and distal resection margins for PPG, meaning more remnant stomach would be preserved in PPG.
Choice of DNA extraction method affects stool microbiome recovery and subsequent phenotypic association analyses
Authors: Fernández-Pato Asier , Sinha Trishla , Gacesa Ranko , Gois Milla F. Brandao , Gelderloos-Arends Jody , Jansen Dianne B.H. , Jaeger Martin , Joosten Leo A.B. , Netea Mihai G. , Weersma Rinse K. , Wijmenga Cisca , Harmsen Hermie J.M. , Fu Jingyuan , Zhernakova Alexandra , Kurilshikov Alexander 
Published: August 2022

Abstract
Background: Interest in microbiome research has increased exponentially in recent years. However, the growth in the number of studies has outpaced the standardization of the processing and analysis of microbiome samples. This lack of standardization represents a major limitation that hampers the replication of results across studies and the clinical translation of research findings. The major source of variation in microbiome results on the experimental side are differences in the methods of DNA extraction from fecal samples. In this study, we aimed to compare the metagenomic profiles obtained by using two commercially available DNA extraction kits, and their effects on microbiome diversity, composition and associations to phenotypes. Methods and Results: We compared two commonly used DNA extraction kits, the AllPrep DNA/RNA Mini Kit (APK) and the QIAamp Fast DNA Stool Mini Kit (FSK), in 745 paired samples from two independent population cohorts: Lifelines-DEEP (LLD, n = 292), and 500 Functional Genomics project (500FG, n = 453). We evaluated the performance of both methods for DNA yield and quality and explored whether the DNA extraction protocol introduces heterogeneity in microbiota composition and diversity or in phenotype–microbiome associations. In both cohorts, APK protocol yields a higher DNA concentration and alpha diversity, with 25% and 10% more bacterial species being detected in comparison to the FSK method in LLD and 500FG cohorts, respectively. Both extraction kits result in markedly different community composition and microbial abundances, with >80% of species being differentially abundant in both cohorts. Species belonging to Firmicutes and Actinobacteria show increased abundances in the APK protocol, whereas Bacteroidetes and Proteobacteria are more prevalent in FSK samples. These differences lead to significant variations in the phenotypic association profile with gut microbes.Conclusions: The results of this study further reinforce that choice of DNA extraction method impacts metagenomic profile of human gut microbiota. We demonstrate that accounting for differences in fecal sample processing is essential for improving the reproducibility of microbiome research findings.
Comparing performance of classification algorithms to use for grading coffee raw quality by using image processing techniques.
Authors: Bedaso Muktar , Meshesha Million , Diriba Chala 
Published: August 2022

Abstract
This study tries to apply digital image processing techniques towards sample Coffee raw quality value grading. More specifically, this study emphases on comparing performance of classification algorithms to use for grading Coffee raw quality by using image processing methods. To ease experimentation image processing phases are followed, including image acquisition, image preprocessing (image filtering and attribute selection), image analysis (segmentation, feature extraction and classification), and image understanding for raw quality image grading. Artificial Neural Network, support vector machine and K-Nearest neighbor classifiers on each classification parameter of morphology, color and the mixture of the two has been made. Experimental outcomes confirm that Artificial Neural Network classifier generated the highest performance of 89.45% accuracy as compared to support vector machine (with 83.75%) and K-Nearest neighbor classifier (with 77.85%). Thus, suitable selection of image processing and classification techniques paves the way for higher accuracy in the higher-level process for decision making.
Green synthesis and characterization of gold nanoparticles for optical biosensing applications
Authors: Rodrigues Eloise P. , Melo Arthur A. , Vasconcelos Jomar S. , Medeiros Eliton S. , Oliveira Leiva C. , Lima Antonio M.N. 
Published: August 2022

Abstract
The goal of the current study is to show how to use green synthesis to create gold nanoparticles, and present a method to determine the dielectric constant of nanoparticles solutions that are used in optical biosensing applications. Green tea (Camellia sinensis) leaf extract was used as a reducing agent to obtain nanoparticles. The gold nanoparticles were synthesized for different concentrations of green tea, directly impacting the particle's size and refractive index. The experimental data from the absorption spectroscopy of colloidal solutions and the zeta test potential were used to determine the dielectric parameters of the gold nanoparticles. Three theoretical expressions proposed for the electrical permittivity have been used to estimate the measured absorption coefficient. The behavior of the estimated absorption coefficient curves is quite similar to the curves obtained from the UV-Vis spectrophotometry. The absolute error of the peak value of the absorption coefficient is less than 1.5\% in the case of the theoretical expression that most accurately describes the dielectric constant of the colloidal solution of gold nanoparticles.
Assessing the impacts of droughts on small ruminants grazing areas and respective soil hydrological responses
Authors: MINEA Gabriel , Ciobotaru Nicu , (Stan) Florentina-Iuliana Mincu , Neculau Gianina , Strat Daniela , Fernández-Gálvez Jesús , Mircea Sevastel 
Published: August 2022

Abstract

Recent studies affirm that climate change is affecting areas worldwide, particularly long droughts, which would transform many fertile territories into degraded areas. This could imply significant impacts and natural hazards influencing both water and soil resources and, subsequently, plant species composition and biodiversity. One of the affected land use and related type of ecosystem are the pastures of the hills with small ruminants (sheep and goats). However, there is a lack of studies aimed to develop integrated hydrological and climate approaches to assess these possible impacts in countries such as Romania. Therefore, this study aims to evaluate drought impacts on hills pastures occupied by small ruminants (SRs) based on the analysis of aridity indices, rainfall simulation experiments, and field surveys (e.g., soil profiles and vegetation transects) in an experimental plot located in the Curvature Subcarpathians of Romania. Preliminary results show high monthly variability of aridity, vertical dehydrated layers in the main soil types (chernozems exhibiting shrinkage and swelling processes), degraded herbaceous vegetation, and high runoff coefficient for bare soils. At the hillslope scale, vegetation, SRs, and water occurrence (e.g., low runoff coefficients and high infiltration rates) are strongly affected by droughts, especially during August and September. The intensification of SRs grazing in these areas (under dry conditions) amplifies the drought effects on the environment (e.g., soil compaction, grass depletion, water scarcity). Our field observations do not support SRs grazing as a major driving factor for land degradation, but unsustainable SRs grazing can drastically induce changes in seasonally available soil water content under arid conditions.
Heterogeneity in the course of suicidal ideation and its relation to suicide attempts in first-episode psychosis: a five-year prospective study
Authors: Sicotte Roxanne , Iyer Srividya N. , Lacourse Eric , Séguin Jean R. , Abdel-Baki Amal 
Published: August 2022

Abstract
Background
Although the risk of suicide is high in first-episode psychosis (FEP), little is known about the course of suicidal ideation and its relation with suicide attempts.
Aims
To identify five-year trajectories of suicidal ideation and associated factors in FEP and compare how suicide attempts were distributed across these identified trajectories.
Method
This five-year prospective study assessed suicidal ideation, suicide attempts and potentially associated factors through research interviews, chart review and coroner's reports in 382 FEP patients [mean age = 23.53(SD = 3.61)] admitted to two five-year early psychosis services in Montreal, Canada. Trajectories were identified using a semiparametric mixture model, and associated factors with multinomial logistic regression.
Results
Three suicidal ideation trajectories were identified : low and decreasing (85.08%); early decline, then increasing (7.85%), and persistent suicidal ideation (7.07%). Suicidal ideation prior to admission (OR = 2.85,p < 0.05) and cocaine use disorder (OR = 6.78,p < 0.05) were associated with the early decline, then increasing suicidal ideation trajectory. Persons with prior suicide ideation (OR = 4.33,p < 0.05) and attempts (OR = 8.18,p < 0.001) and alcohol use disorder (OR = 3.63, p < 0.05) were more likely to belong to the persistent suicidal ideation trajectory, and to attempt suicide during follow-up.
Conclusions
Our study highlights heterogeneity in the course of suicidal ideation over five years and the importance of ongoing assessment of suicidal risk in FEP patients, particularly during periods of transition to other services and for patients who persistently report suicidal ideation, as they are more likely to engage in suicide attempts. Patients with factors associated with increased or persistent suicidal ideation trajectories should be targeted for suicide prevention interventions.