bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detrital zircon U–Pb age constraints on the Meso-Tethys Ocean closure in SE Asia
Authors: Mo Jing , Xia Xiao-Ping , Zhou Meiling , Lai Chun-Kit , Cui Zexian , Xu Jian , Aidoo Felix 
Published: October 2022

Abstract

The location of the Meso-Tethyan suture in SE Asia is ambiguous due to the strong overprint by the later India–Asia collisional tectonics. For the SE Asian extension of the Meso-Tethyan Bangong–Nujiang Suture (BNS) in Tibet, the two main candidates are the Longling–Ruili Suture (between the Tengchong and Baoshan blocks) and the Myitkyina ophiolite belt. Here, we present new detrital zircon U–Pb ages from high-grade metasedimentary rocks of the Gaoligong Group, which is considered to be the basement of the Tengchong Block located between the Longling–Ruili Suture and Myitkyina ophiolite belt. Our data suggest that the Gaoligong Group contains Cambrian, Triassic and Cretaceous zircons and is not a Precambrian basement, with a diagnostic age population peak at
c.
1110 Ma. This peak is comparable to the
c.
1170 Ma peak reported in the Australia-derived blocks (e.g. Lhasa and West Australia). Such similarities, as well as the similarities in the stratigraphy, palaeobiogeography and magmatic history of the Tengchong Block, suggest that the Tengchong Block was located adjacent to the northern Australia margin in Gondwana, and was most likely to have been linked with the Lhasa Block (southern Tibet) since the Early Paleozoic. Thus, the Longling–Ruili Suture is likely to represent a continuation of the Meso-Tethyan BNS in SE Asia.
Tectonic evolution of the Proto-Qiangtang Ocean and its relationship with the Palaeo-Tethys and Rheic oceans
Authors: Dan Wei , Murphy J. Brendan , Wang Qiang , Zhang Xiu-Zheng , Tang Gong-Jian 
Published: October 2022

Abstract
An evaluation of the potential geodynamic connections between the evolution of Paleozoic oceans in NW Gondwana and NE Gondwana is challenging. Until recently, most syntheses emphasized only two Paleozoic oceans (the Proto-Tethys and the Palaeo-Tethys) in the east Tethys realm. However, the discovery of early Paleozoic ophiolites along Palaeo-Tethys sutures located south of Proto-Tethys sutures challenges these traditional views. After a comprehensive review of relevant early Paleozoic tectonomagmatic events, we herein recognize and propose a model for the tectonic evolution of a hitherto unrecognized early Paleozoic ocean, which we call the Proto-Qiangtang Ocean. This ocean was short lived; it opened in the late Cambrian, began to subduct in the Middle Ordovician, and closed diachronously westwards between the Late Ordovician and the middle Silurian. Its closure by middle Silurian time indicates that was a spatially and temporally distinct ocean from the Palaeo-Tethys Ocean. The early tectonic evolution of the Proto-Qiangtang Ocean shares many characteristics with that of the Rheic Ocean. Both opened in the late Cambrian in the back-arc region of the Iapetus–Proto-Tethys Ocean, and the Proto-Qiangtang Ocean is considered to represent the eastern extension of the Rheic Ocean. This correlation has important implications for the Paleozoic tectonic evolution and palaeogeography of northern Gondwana.
Continents never forget: seismological record of lithospheric deformation 1 billion years ago
Authors: Levin Vadim , Yuan Huaiyu , Hynes Andrew 
Published: October 2022

Abstract
A seismic array extended from the Grenville Province into the Abitibi and Opatica subprovinces of the Superior Province, Canada. We use P-to-S converted waves in seismograms of distant earthquakes to probe boundaries in seismic properties, and demonstrate the presence of a prominent seismic feature that dips NNW into the mantle beneath the Grenville Front. We use two variants of receiver function (RF) analysis, a common conversion-point (CCP) imaging that combines seismic signals from multiple paths connecting sources and receivers, and harmonic decomposition of RF data that separates signals according to their direction in the cone of paths from which the signals have come. CCP images show the crust beneath the Grenville Province to be thicker than beneath the Superior Province, and identify a NNW-dipping boundary beneath the Grenville Front. Harmonic RF analysis shows that this feature is associated with seismic anisotropy in upper-mantle peridotite, and that this anisotropic feature extends to depths of at least 70 km. We interpret the feature as the result of a NNW-dipping shear zone formed within the mantle lithosphere during the Grenvillian continental collision. It could have accommodated internal deformation within Laurentian lithosphere or, more speculatively, mark the contact with the impacting Amazonian lithosphere.
Dietary Niacin Requirement of Juvenile Chinese Mitten Crab, Eriocheir sinensis
Authors: Liu Xuran , Wan Wenlong , Li Mengge , Shi Jiayuan , Xu Jie , Zhou Zihan , Wang Anran , Miao Shuyan 
Published: October 2022

Effects of dietary niacin on the growth performance, intestinal histomorphology, body composition, and antioxidant capacity were investigated in the present study to determine the optimum requirement of niacin for juvenile Eriocheir sinensis. All 360 crabs (initial average weight

1.14
±
0.04

g) were randomly divided into 6 groups with 3 replicates in each group and 20 crabs in each replicate. Crabs were fed with the control diet (0.89 mg/kg) or niacin-supplemented diets (170.54 mg/kg, 347.05 mg/kg, 587.59 mg/kg, 784.85 mg/kg, and 1248.86 mg/kg) for 12 weeks (named as G1, G2, G3, G4, G5, and G6, respectively). The results showed that appropriate dietary niacin (above 347.05 mg/kg) significantly increased the weight gain rate (WGR) and specific growth rate (SGR) (

p
<
0.05

), but did not affect the survival rate (SR), feed conversion ratio (FCR), daily feeding rate (DFR), and molting frequency (MF) of crabs (

p
>
0.05

). The niacin content in the hepatopancreas of crabs in G1 and G2 was significantly lower than that of the other four groups (

p
<
0.05

). Moreover, dietary niacin significantly affected the intestinal histomorphology of crabs, including the number of folds (NF), height of folds (HF), height of microvillus (HMV), and thickness of muscularis (TM) (

p
<
0.05

). Additionally, moderate dietary niacin levels significantly affected the nonspecific immune responses of crabs, by improving the activity of catalase (CAT), glutathione s-transferase (GST), glutathione peroxidase (GSH-Px), and total superoxide dismutase (T-SOD) (

p
<
0.05

). Based on the broken-line model analysis of SGR against dietary niacin level, the dietary niacin requirement of juvenile crabs was suggested to be 419.4 mg/kg.
Diet Quality and Pancreatic Cancer Incidence in the Multiethnic Cohort
Authors: Steel Heather , Park Song-Yi , Lim Tiffany , Stram Daniel O. , Boushey Carol J. , Hébert James R. , Le Marchand Loïc , Wu Anna H. , Setiawan Veronica Wendy 
Published: October 2022

Abstract

Background:
Data on diet quality and pancreatic cancer are limited. We examined the relationship between diet quality, assessed by the Healthy Eating Index-2015 (HEI-2015), the Alternative Healthy Eating Index-2010 (AHEI-2010), the alternate Mediterranean Diet (aMED) score, the Dietary Approaches to Stop Hypertension (DASH) score and the energy-adjusted Dietary Inflammatory Index (E-DII), and pancreatic cancer incidence in the Multiethnic Cohort Study.

Methods:
Diet quality scores were calculated from a validated food frequency questionnaire administered at baseline. Cox models were used to calculate HR and 95% confidence intervals (CI) adjusted for age, sex, race/ethnicity, education, diabetes, family history of pancreatic cancer, physical activity, smoking variables, total energy intake, body mass index (BMI), and alcohol consumption. Stratified analyses by sex, race/ethnicity, smoking status, and BMI were conducted.

Results:
Over an average follow-up of 19.3 years, 1,779 incident pancreatic cancer cases were identified among 177,313 participants (average age of 60.2 years at baseline, 1993–1996). Overall, we did not observe associations between the dietary pattern scores and pancreatic cancer (aMED: 0.98; 95% CI, 0.83–1.16; HEI-2015: 1.03; 95% CI, 0.88–1.21; AHEI-2010: 1.03; 95% CI, 0.88–1.20; DASH: 0.92; 95% CI, 0.79–1.08; E-DII: 1.05; 95% CI, 0.89–1.23). An inverse association was observed with DASH for ever smokers (HR, 0.75; 0.61–0.93), but not for nonsmokers (HR, 1.05; 0.83–1.32).

Conclusions:
The DASH diet showed an inverse association with pancreatic cancer among ever smokers, but does not show a protective association overall.

Impact:
Modifiable measures are needed to reduce pancreatic cancer burden in these high-risk populations; our study adds to the discussion of the benefit of dietary changes.
Healthcare Access Domains Mediate Racial Disparities in Ovarian Cancer Treatment Quality in a US Patient Cohort: A Structural Equation Modelling Analysis
Authors: Akinyemiju Tomi , Chen Quan , Wilson Lauren E. , Previs Rebecca A. , Joshi Ashwini , Liang Margaret , Pisu Maria , Ward Kevin C. , Berchuck Andrew , Schymura Maria J. , Huang Bin 
Published: October 2022

Abstract

Background:
Ovarian cancer survival disparities have persisted for decades, driven by lack of access to quality treatment. We conducted structural equation modeling (SEM) to define latent variables representing three healthcare access (HCA) domains: affordability, availability, and accessibility, and evaluated the direct and indirect associations between race and ovarian cancer treatment mediated through the HCA domains.

Methods:
Patients with ovarian cancer ages 65 years or older diagnosed between 2008 and 2015 were identified from the SEER-Medicare dataset. Generalized SEM was used to estimate latent variables representing HCA domains by race in relation to two measures of ovarian cancer-treatment quality: gynecologic oncology consultation and receipt of any ovarian cancer surgery.

Results:
A total of 8,987 patients with ovarian cancer were included in the analysis; 7% were Black. The affordability [Ω: 0.876; average variance extracted (AVE) = 0.689], availability (Ω: 0.848; AVE = 0.636), and accessibility (Ω: 0.798; AVE = 0.634) latent variables showed high composite reliability in SEM analysis. Black patients had lower affordability and availability, but higher accessibility compared with non-Black patients. In fully adjusted models, there was no direct effect observed between Black race to receipt of surgery [β: −0.044; 95% confidence interval (CI), −0.264 to 0.149]; however, there was an inverse total effect (β: −0.243; 95% CI, −0.079 to −0.011) that was driven by HCA affordability (β: −0.025; 95% CI, −0.036 to −0.013), as well as pathways that included availability and consultation with a gynecologist oncologist.

Conclusions:
Racial differences in ovarian cancer treatment appear to be driven by latent variables representing healthcare affordability, availability, and accessibility.

Impact:
Strategies to mitigate disparities in multiple HCA domains will be transformative in advancing equity in cancer treatment.
Impact of Moderate–Vigorous Physical Activity Trajectories on Colon Cancer Risk over the Adult Life Course
Authors: Christopher Cami N. , Matthews Charles E. , Saint-Maurice Pedro F. , Keadle Sarah Kozey 
Published: October 2022

Abstract

Background:
Moderate-vigorous physical activity (MVPA) reduces colon cancer risk; however, it is unclear how the timing of MVPA throughout the adult life course impacts colon cancer risk. We evaluated whether maintenance and changes in MVPA levels over time are associated with colon cancer risk.

Methods:
We assessed 293,198 adults ages 50 to 71 years in the NIH-AARP Diet and Health Study. Participants completed baseline health and physical activity questionnaires between 1995 and 1997 and were followed through 2011, (average follow-up of 13.1 years). There were 5,072 colon cancer cases over the study period. Using latent class trajectory models, we identified seven distinct MVPA trajectories across the adult life course (15–18, 19–29, 30–35, and past 10-years) and ran Cox proportional hazards regression models.

Results:
Compared with those who maintained low MVPA levels, those who maintained high and moderate levels of MVPA had a lower risk of colon cancer [HR, 0.85; confidence interval (CI), 0.78–0.93; HR = 0.87; CI, 0.76–1.00)], and those who increased MVPA levels early and later during adulthood had a lower colon cancer risk (HR, 0.90; CI, 0.80–1.01) and (HR, 0.92; CI, 0.80–1.06), respectively. Those who decreased MVPA early in adulthood had an increased risk of colon cancer (HR, 1.12; CI, 1.02–1.23). These associations were stronger in adults ages &lt;65 years at baseline and in men (P &lt; 0.001).

Conclusions:
Consistent participation in MVPA throughout life may reduce colon cancer risk.

Impact:
These findings emphasize that engaging in MVPA throughout adulthood lowers risk of colon cancer.
Criteria for Early Pacemaker Implantation in Patients With Postoperative Heart Block After Congenital Heart Surgery
Authors: Duong Son Q. , Shi Yuan , Giacone Heather , Navarre Brittany M. , Gal Dana B. , Han Brian , Sganga Danielle , Ma Michael , Reddy Charitha D. , Shin Andrew Y. , Kwiatkowski David M. , Dubin Anne M. , Scheinker David , Algaze Claudia A. 
Published: October 2022

Background:
Guidelines recommend observation for atrioventricular node recovery until postoperative days (POD) 7 to 10 before permanent pacemaker placement (PPM) in patients with heart block after congenital cardiac surgery. To aid in surgical decision-making for early PPM, we established criteria to identify patients at high risk of requiring PPM.

Methods:
We reviewed all cases of second degree and complete heart block (CHB) on POD 0 from August 2009 through December 2018. A decision tree model was trained to predict the need for PPM amongst patients with persistent CHB and prospectively validated from January 2019 through March 2021. Separate models were developed for all patients on POD 0 and those without recovery by POD 4.

Results:

Of the 139 patients with postoperative heart block, 68 required PPM. PPM was associated with older age (3.2 versus 1.0 years;
P
=0.018) and persistent CHB on POD 0 (versus intermittent CHB or second degree heart block; 87% versus 58%;
P
=0.001). Median days [IQR] to atrioventricular node recovery was 2 [0–5] and PPM was 9 [6–11]. Of the 100 cases of persistent CHB (21 in the validation cohort), 59 (59%) required PPM. A decision tree model identified 4 risk factors for PPM in patients with persistent CHB: (1) aortic valve replacement, subaortic stenosis repair, or Konno procedure; (2) ventricular L-looping; (3) atrioventricular valve replacement; (4) and absence of preoperative antiarrhythmic agent (in POD 0 model only). The POD 4 model specificity was 0.89 [0.67–0.99] and positive predictive value was 0.94 [95% CI 0.81–0.98], which was stable in prospective validation (positive predictive value 1.0).

Conclusions:
A data-driven analysis led to actionable criteria to identify patients requiring PPM. Patients with left ventricular outflow tract surgery, atrioventricular valve replacement, or ventricular L-Looping could be considered for PPM on POD 4 to reduce risks of temporary pacing and improve care efficiency.
Don't You Forget About Me: The Importance of Studying the Brain Basis of Real-world Interpersonal Memory
Authors: Meyer Meghan L. 
Published: October 2022

Abstract
Despite the fact that humans are a highly social species, we know relatively little about how people remember the rich interpersonal information filling their social lives. This gap is surprising: One function of memory has been suggested to be relationship maintenance [Neisser, U. Time present and time past. Practical Aspects of Memory: Current Research and Issues, 2, 545–560, 1988]. A major barrier to understanding the brain basis of interpersonal memory is that traditional brain imaging methods are not ideally suited to study memory for the nuanced interpersonal experiences comprising our social lives. Yet, recent and rapidly developing advances in the analysis of brain responses to naturalistic social information can help researchers surpass this methodological barrier. This perspective piece articulates the importance of studying the brain basis of real-world social memories and suggests new directions in interpersonal memory research. This includes investigating the brain mechanisms that represent the content and structure of real-world interpersonal memories as well as how they are altered in mental health conditions associated with social memory biases.
10 Simple Rules for a Supportive Lab Environment
Authors: Pike Alexandra C. , Atherton Kathryn E. , Bauer Yannik , Crittenden Ben M. , van Ede Freek , Hall-McMaster Sam , von Lautz Alexander H. , Muhle-Karbe Paul S. , Murray Alexandra M. , Myers Nicholas E. , Printzlau Frida , Salaris Ilenia , Spaak Eelke , Tankelevitch Lev , Trübutschek Darinka , Wasmuht Dante , Noonan MaryAnn P. 
Published: October 2022

Abstract
The transition to principal investigator (PI), or lab leader, can be challenging, partially due to the need to fulfil new managerial and leadership responsibilities. One key aspect of this role, which is often not explicitly discussed, is creating a supportive lab environment. Here, we present ten simple rules to guide the new PI in the development of their own positive and thriving lab atmosphere. These rules were written and voted on collaboratively, by the students and mentees of Professor Mark Stokes, who inspired this piece.
Quiet Trajectories as Neural Building Blocks
Authors: Manohar Sanjay 
Published: October 2022

Abstract
Our concept of the neural mechanisms of working memory has recently undergone an upheaval, because of two transformative concepts: multivariate neural state trajectories and the activity-silent hypothesis. I will argue that putting these concepts together raises the difficult problem of “quiet trajectories,” where future neural activity is not fully determined by current activity. However, this also promises new building blocks for neural computation.
Modular Brain, Entangled Argument
Authors: Krakauer John W. 
Published: October 2022

Abstract
It has become a truism that the brain is a complex structure. One idea associated with complex systems is that of emergence, which is often characterized as the occurrence of a novel collective property that results from the interactions of individual parts, each of which alone do not have that property. Pessoa in his book argues, plausibly, that given that cognition is the most complex thing the brain does then it will need a new emergence-inflected science to understand it. His subsequent argument, however, does not follow, namely that this will take the form of distributed networks with identity-switching nodes that morph pluripotently from one computation to another. This is not true for whole organisms, which became more complex through compartmentalization and specialization. The brain did the same with hierarchically organized specialized areas.
Post-encoding Reactivation Is Related to Learning of Episodes in Humans
Authors: Wu Xiongbo , Viñals Xavier , Ben-Yakov Aya , Staresina Bernhard P. , Fuentemilla Lluís 
Published: October 2022

Abstract
Prior animal and human studies have shown that post-encoding reinstatement plays an important role in organizing the temporal sequence of unfolding episodes in memory. Here, we investigated whether post-encoding reinstatement serves to promote the encoding of “one-shot” episodic learning beyond the temporal structure in humans. In Experiment 1, participants encoded sequences of pictures depicting unique and meaningful episodic-like events. We used representational similarity analysis on scalp EEG recordings during encoding and found evidence of rapid picture-elicited EEG pattern reinstatement at episodic offset (around 500 msec post-episode). Memory reinstatement was not observed between successive elements within an episode, and the degree of memory reinstatement at episodic offset predicted later recall for that episode. In Experiment 2, participants encoded a shuffled version of the picture sequences from Experiment 1, rendering each episode meaningless to the participant but temporally structured as in Experiment 1, and we found no evidence of memory reinstatement at episodic offset. These results suggest that post-encoding memory reinstatement is akin to the rapid formation of unique and meaningful episodes that unfold over time.
Seeing an Auditory Object: Pupillary Light Response Reflects Covert Attention to Auditory Space and Object
Authors: Liao Hsin-I , Fujihira Haruna , Yamagishi Shimpei , Yang Yung-Hao , Furukawa Shigeto 
Published: October 2022

Abstract
Attention to the relevant object and space is the brain's strategy to effectively process the information of interest in complex environments with limited neural resources. Numerous studies have documented how attention is allocated in the visual domain, whereas the nature of attention in the auditory domain has been much less explored. Here, we show that the pupillary light response can serve as a physiological index of auditory attentional shift and can be used to probe the relationship between space-based and object-based attention as well. Experiments demonstrated that the pupillary response corresponds to the luminance condition where the attended auditory object (e.g., spoken sentence) was located, regardless of whether attention was directed by a spatial (left or right) or nonspatial (e.g., the gender of the talker) cue and regardless of whether the sound was presented via headphones or loudspeakers. These effects on the pupillary light response could not be accounted for as a consequence of small (although observable) biases in gaze position drifting. The overall results imply a unified audiovisual representation of spatial attention. Auditory object-based attention contains the space representation of the attended auditory object, even when the object is oriented without explicit spatial guidance.
There Is More Evidence of Rhythmic Attention than Can Be Found in Behavioral Studies: Perspective on Brookshire,
Authors: Fiebelkorn Ian C. 
Published: October 2022

Abstract
Recent research indicates periodicity in attention-related sampling and switching, with some of the initial findings coming from behavioral studies. Brookshire [Brookshire, G. Putative rhythms in attentional switching can be explained by aperiodic temporal structure. Nature Human Behaviour, 2022, https://doi.org/10.1038/s41562-022-01364-0], points out that widely used approaches to testing for rhythms in behavioral times series can misclassify consistent aperiodic patterns in temporal structure as periodic patterns. Evidence for rhythmic attention, however, is not limited to behavioral data. Here, I briefly discuss (i) issues with differentiating periodic and aperiodic structure in both behavioral and neural time series, (ii) findings from neural data that are consistent with rhythmic sampling and switching during attentional deployment, and (iii) whether alternative approaches to establishing periodicity in behavioral time series, recommended by Brookshire are appropriate for this particular research topic.