bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infección por SARS-CoV-2 y su impacto en la enfermedad hepática
Authors: Salgüero Fernández Sergio , Gabriel Medina Pablo , Almería Lafuente Alejandro , Ballesteros Vizoso María Antonieta , Zamora Trillo Angielys , Casals Mercadal Gregori , Solé Enrech Gemma , Lalana Garcés Marta , Guerra Ruiz Armando R. , Ortiz Pastor Oihana , Morales Ruiz Manuel 
Published: June 2022

Resumen

Introducción
En el contexto de la infección por SARS-CoV-2 no es infrecuente encontrar alteraciones hepáticas, tanto en pacientes con enfermedad hepática crónica previa como sin ella.

Contenido
En esta revisión, se examina el conocimiento actual sobre la relación entre la COVID-19 y el daño hepático, frecuentemente observado en el seno de esta enfermedad.

Resumen
Si bien no está completamente dilucidada la patogénesis del daño hepático, parece ser consecuencia de la combinación de varios factores, entre los que se encuentran el daño directo del virus, el derivado de la hiperactivación del sistema inmune, el isquémico y el farmacológico. El valor pronóstico de estas alteraciones también está bajo intensa investigación. La potencial repercusión de las mismas aboga por la necesidad de adecuar el manejo y el tratamiento de los pacientes, particularmente en el contexto de pacientes con enfermedad hepática crónica o trasplantados hepáticos.

Perspectiva
Se desconocen actualmente muchos aspectos relativos a la afectación hepática durante la COVID-19, particularmente en las formas graves de la enfermedad. El desarrollo de nuevos estudios referidos a las implicaciones clínicas de la COVID-19 en el hígado, tanto en estado sano como enfermo, podrían ayudar a ajustar las recomendaciones de tratamiento y vacunación según el perfil del paciente.
Impact of SARS-CoV-2 infection on liver disease
Authors: Salgüero Fernández Sergio , Gabriel Medina Pablo , Almería Lafuente Alejandro , Ballesteros Vizoso María Antonieta , Zamora Trillo Angielys , Casals Mercadal Gregori , Solé Enrech Gemma , Lalana Garcés Marta , Guerra Ruiz Armando R. , Ortiz Pastor Oihana , Morales Ruiz Manuel 
Published: June 2022

Abstract

Introduction
Abnormal liver biochemistry is not a rare finding in the context of SARS-CoV-2 infection, regardless of patients having pre-existing chronic disease or not

Content
This review examines the current body of knowledge on the relationship between COVID-19 and liver injury, which is frequently found in this setting

Summary
Although the pathogenesis of liver injury is not fully understood, it has been suggested to be the result of a combination of multiple factors. These include direct injury caused by the virus, immune system hyperactivation, ischemic and drug-induced injury. The prognostic valor of these alterations is also the subject of intense research. Due to their potential impact, these alterations require proper management and treatment, especially in patients with chronic liver disease or liver transplant recipients.

Outlook
Some aspects associated with liver injury during COVID-19, especially in severe presentations, are not well understood. Studies assessing the clinical impact of COVID-19 on the healthy or diseased liver may help adjust treatment and immunization guidelines to the profile of the patient.
Behavior of reactive powder concrete containing recycled glass powder reinforced by steel fiber
Authors: Hussain Zainab Ali , Aljalawi Nada Mahdi Fawzi 
Published: June 2022

AbstractEnvironmental sustainability is described as one that avoids the depletion or deterioration of natural resources, while also allowing for the preservation of long-term environmental quality. By practicing environmental sustainability, we may assist to guarantee that the requirements of today’s population are satisfied without risking the capacity of future generations to meet their own needs in the future. Engineers in the field of concrete production are becoming increasingly interested in sustainable development, which includes the utilization of the locally available materials in addition to using the agricultural and industrial waste in construction industry as one of the possible solutions to the environmental and economic issues. This study investigated the effect of partial substitution of cement with recycled glass powder (0, 15, 20, and 25%) by weight of cement at various ages (on compressive strength) after determining the optimal ratio of replacement. This optimal ratio is used to study its effect on some mechanical properties (such as flexural strength, absorption, and dry density) of reactive powder concrete containing 1% micro steel fiber (SRPC), and furthermore, utilizing steam curing for 5 h at 90°C after hardening the sample directly. Reactive powder concrete (RPC) has been designed with the use of the local cement, silica fume, and super plasticizer with a water/cement ratio of 0.20 in order to achieve a compressive strength of 137.09 MPa at the age of 28 days. When recycled glass powder replacement (20%) was utilized, the findings revealed that the compressive strength of RPC improved by 4.2%, the flexural strength increased by 15.3%, the dry density increased by 0.61%, and the absorption was reduced by 32% at 28 days after the test results were compared to the reference mix.
A Prosopographical Study of the ỉmʒ-ʿ Title Holders down to the End of the Old Kingdom
Authors: González León Daniel 
Published: June 2022

Summary
The first part of this paper was published in the second issue of ZÄS 148 (2021). The sources of the ỉmʒ-ʿ title were presented in order to examine their nature, their provenance, and the social and historical context of the title’s holder. This second part contains the actual prosopographical list consisting of 37 entries, namely the documentation which supports the contents of Part 1.
Die Morphologie der Verben für “sitzen” und “stehen” in den oberägyptischen koptischen Dialekten
Authors: Peust Carsten 
Published: June 2022

Summary
Unlike the principal Coptic dialects Sahidic and Bohairic, in which the two verbs for “to sit” and “to stand” possess just a single form each, the Southern Coptic dialects (Akhmimic, Lycopolitan, dialect P) have preserved a formal distinction between the infinitive and the stative in both verbs. This information remains hidden in a few text editions, is not widely known and not reflected in current handbooks. The present paper traces the original morphological distinction for both verbs in the major textual witnesses of the South, as well as the progressive morphological collapse that lead to the uniform shapes of these verbs in the dominant dialects. Finally, an etymology is suggested for the puzzling Sahidic standard form ϩⲙⲟⲟⲥ “to sit”.
Palmitoylation of γb protein directs a dynamic switch between Barley stripe mosaic virus replication and movement
Authors: Yue Ning , Jiang Zhihao , Zhang Xuan , Li Zhenggang , Wang Xueting , Wen Zhiyan , Gao Zongyu , Pi Qinglin , Zhang Yongliang , Wang Xian‐Bing , Han Chenggui , Yu Jialin , Li Dawei 
Published: June 2022

AbstractViral replication and movement are intimately linked; however, the molecular mechanisms regulating the transition between replication and subsequent movement remain largely unknown. We previously demonstrated that the Barley stripe mosaic virus (BSMV) γb protein promotes viral replication and movement by interacting with the αa replicase and TGB1 movement proteins. Here, we found that γb is palmitoylated at Cys‐10, Cys‐19, and Cys‐60 in Nicotiana benthamiana, which supports BSMV infection. Intriguingly, non‐palmitoylated γb is anchored to chloroplast replication sites and enhances BSMV replication, whereas palmitoylated γb protein recruits TGB1 to the chloroplasts and forms viral replication‐movement intermediate complexes. At the late stages of replication, γb interacts with NbPAT15 and NbPAT21 and is palmitoylated at the chloroplast periphery, thereby shifting viral replication to intracellular and intercellular movement. We also show that palmitoylated γb promotes virus cell‐to‐cell movement by interacting with NbREM1 to inhibit callose deposition at the plasmodesmata. Altogether, our experiments reveal a model whereby palmitoylation of γb directs a dynamic switch between BSMV replication and movement events during infection.
Malaria parasites release vesicle subpopulations with signatures of different destinations
Authors: Abou Karam Paula , Rosenhek‐Goldian Irit , Ziv Tamar , Ben Ami Pilo Hila , Azuri Ido , Rivkin Anna , Kiper Edo , Rotkopf Ron , Cohen Sidney R , Torrecilhas Ana Claudia , Avinoam Ori , Rojas Alicia , Morandi Mattia I , Regev‐Rudzki Neta 
Published: June 2022

AbstractMalaria is the most serious mosquito‐borne parasitic disease, caused mainly by the intracellular parasite Plasmodium falciparum. The parasite invades human red blood cells and releases extracellular vesicles (EVs) to alter its host responses. It becomes clear that EVs are generally composed of sub‐populations. Seeking to identify EV subpopulations, we subject malaria‐derived EVs to size‐separation analysis, using asymmetric flow field‐flow fractionation. Multi‐technique analysis reveals surprising characteristics: we identify two distinct EV subpopulations differing in size and protein content. Small EVs are enriched in complement‐system proteins and large EVs in proteasome subunits. We then measure the membrane fusion abilities of each subpopulation with three types of host cellular membranes: plasma, late and early endosome. Remarkably, small EVs fuse to early endosome liposomes at significantly greater levels than large EVs. Atomic force microscope imaging combined with machine‐learning methods further emphasizes the difference in biophysical properties between the two subpopulations. These results shed light on the sophisticated mechanism by which malaria parasites utilize EV subpopulations as a communication tool to target different cellular destinations or host systems.
Adult-onset Langerhans cell histiocytosis changing CNS lesion from pituitary to suprasellar extension
Authors: Kadowaki Yuji , Nishiyama Mitsuru , Nakamura Makoto , Morisaka Hiroyuki , Fujimoto Shimpei , Terada Yoshio , Kojima Kensuke 
Published: June 2022

Summary
Langerhans cell histiocytosis (LCH) is a rare disease characterized by the proliferation of abnormal Langerhans cells in various tissues and organs, including bone, skin, the lungs, and the pituitary gland. Hypothalamic–pituitary lesions in LCH often cause central diabetes insipidus (CDI), but the natural course of LCH in the CNS remains to be elucidated. In this study, we report an interesting case of altered LCH lesions in the CNS from the pituitary to the hypothalamus in a 45-year-old woman. She developed symptoms of polyuria and was diagnosed with CDI with lymphocytic hypophysitis due to an enlarged pituitary gland with stalk thickening shown on MRI. Short-term glucocorticoid therapy cured pituitary enlargement, but serum prolactin levels gradually increased. Six years later, the immunohistological findings of a skin biopsy revealed positive for leukocyte common antigen, S-100, and CD1a expression, indicating a diagnosis of LCH. MRI revealed a new lesion in the hypothalamus without pituitary involvement, likely due to LCH. Chemotherapy improved LCH lesions both in the skin and hypothalamus, but therapy was stopped on the patient’s request. Although adult-onset LCH is rare, it should be considered as a differential diagnosis in cases of CDI as the primary disease. The clinical course in the present case indicated that LCH lesion was altered from pituitary to suprasellar extension; where such changes were observed, the possibility of LCH should be considered.

Learning points

Diagnosing the primary disease of CDI is challenging; therefore, careful observation is necessary in pathologically unknown cases.

Enhanced MRI should be performed in cases with suspected hypothalamic lesions, such as elevated serum prolactin.

Although adult-onset LCH is rare, it should be considered a differential diagnosis in cases of CDI as the primary disease.

The direction of changing CNS lesion from pituitary to suprasellar extension might be a unique MRI finding in LCH.
New open-access journal, Redox Experimental Biology, launched by Bioscientifica
Authors: Bioscientifica  
Published: June 2022

Redox Experimental Medicine is a new, fully open-access, peer-reviewed journal publishing redox research that advances our understanding of the effect of redox processes on human health and disease.
Aberrations in redox processes can have a profound impact on the normal physiology of humans, with implications in many diseases. Redox Experimental Medicine will serve as an essential publication for the international scientific community to translate experimental knowledge to redox-based preventive and/or therapeutic interventions, with a view to advancing health. The journal will publish basic and translational articles which have potential therapeutic relevance, as well as pre-clinical and clinical studies.
Led by Editor-in-Chief Professor Giuseppe Poli, from the University of Turin, Redox Experimental Medicine’s highly accomplished and internationally diverse Editorial Board will oversee the rigorous yet rapid peer review of articles.
In his launch Editorial, Professor Poli explains how the journal focuses on an underserved area, commenting that "the experimental investigation of the pathophysiological role of a single molecule or a molecular pathway is certainly essential, but it cannot stand alone and needs to be part of a more comprehensive study project, taking into account the complex reality of the human organism".
Bioscientifica is sponsoring the article publication charge until the end of 2023, enabling Redox Experimental Medicine authors to publish their research on an open-access basis free of charge, offering greater reach and visibility of their work.
Redox Experimental Medicine is now open for submissions. Please take a look at the scope for a full list of topics covered by the journal.
About Bioscientifica
Bioscientifica exists to support biomedicine. Through our publishing expertise we strengthen biomedical communities to advance science and health. Bioscientifica is owned by the UK’s Society for Endocrinology and any profits made through our publications are redistributed to support biomedical research and practice.
Common benign and malignant tumours of the aging skin: Characteristics and treatment options
Authors: Bánvölgyi A. , Görög A. , Gadó K. , Holló P. 
Published: June 2022

Abstract
The incidence of all types of malignant skin tumours, including both melanoma and non-melanoma types, has increased in recent decades, while basal cell carcinoma is the most common human malignancy in the Caucasian race. The aging of the skin is associated with an increase in both benign and malignant tumours. As the population ages and life expectancy extends, mostly in developed countries, dermatologists are likely to face growing numbers of patients seeking therapy for such abnormalities. It is primarily UV irradiation that is responsible for the development of skin cancers, although there are other risk factors, including air pollution and X-ray irradiation. Seborrhoeic keratosis, solar lentigo and other benign lesions, despite their harmless nature, may cause distress to patients, such as itching or aesthetic issues. This review article summarises the features of the most common benign and malignant lesions of aging skin.
The Linear Distance Traveling Tournament Problem
Authors: Hoshino Richard , Kawarabayashi Ken-ichi 
Published: June 2022

We introduce a linear distance relaxation of the n-team Traveling Tournament Problem (TTP), a simple yet powerful heuristic that temporarily "assumes"' the n teams are located on a straight line, thereby reducing the n(n–1)/2 pairwise distance parameters to just n–1 variables. The modified problem then becomes easier to analyze, from which we determine an approximate solution for the actual instance on n teams. We present combinatorial techniques to solve the Linear Distance TTP (LD-TTP) for n = 4 and n = 6, without any use of computing, generating the complete set of optimal distances regardless of where the n teams are located. We show that there are only 295 non-isomorphic schedules that can be a solution to the 6-team LD-TTP, and demonstrate that in all previously-solved benchmark TTP instances on 6 teams, the distance-optimal schedule appears in this list of 295, even when the six teams are arranged in a circle or located in three-dimensional space. We then extend the LD-TTP to multiple rounds, and apply our theory to produce a nearly-optimal regular-season schedule for the Nippon Pro Baseball league in Japan. We conclude the paper by generalizing our theory to the n-team LD-TTP, producing a feasible schedule whose total distance is guaranteed to be no worse than 4/3 times the optimal solution.
The Role of Social Support and Caregiver Burdens among Parents of Children with Cancer
Authors: Roozbeh Behzad , Naemi Mahsa , Soltani Gerdefaramarzi Maryam , Pourmovahed Zahra 
Published: June 2022

Background: Cancer is the most common disease in the present century and the number of affected children is increasing. It can cause many problems for family caregivers. This study assessed the correlation between social support and care-giving burden among parents of children with cancer.
Methods: This cross-sectional descriptive study was conducted by convenience sampling method on 230 parents (115 mothers and 115 fathers) referring to Oncology Clinic and Oncology Ward in Yazd Shahid Sadoughi Hospital (Iran) from March to August 2020 (Covid-19 Pandemics). Researchers asked the patients' parents to answer the questionnaires. The data were gathered by the demographic questionnaire, Care Burden Scale (CBS), and Social Support Scale and analyzed with SPSS21 using Pearson correlation coefficient, Chi-square, and Analysis of Variance (ANOVA) (P=0.05).
Results: The mean of the care burden of parents was 52.19 2.48 and the social support of them was higher than that (78.78± 13.21). There was no significant correlation between social support and domains of general strain (P=0.90), disappointment (P=0.52), emotional involvement (P=0.53), environment (P=0.95), and isolation (P=0.40) of the care burden.
Conclusions: There was no correlation between social support and care burden in the parents of children with cancer. Other factors may be involved in care burden of the parents. More research is needed with more samples in the future.
Investigating the Relationship between Leadership Styles and Positive Organizational Behavior and Stress of COVID 19
Authors: Hosseini Mehri Zadeh , Karimiankakolaki Zohreh 
Published: June 2022

Background: Leadership style is a specific behavioral pattern that is constantly manifested during organizational work and others recognize that person. This study investigated the relationship between leadership styles and positive organizational behavior and stress of COVID-19 in the staff of Shahrekord Health Centers in 2021.
Methods: This research was an applied descriptive correlational study. The sample included 148 people from the staff of Shahrekord health centers in 2021. The participants were selected randomly. The tools used in this research were three questionnaires: Likert leadership style questionnaire, Lutans positive attitude organizational behavior questionnaire, and COVID-19 stress questionnaire. Data were analyzed with SPSS20 using descriptive statistics and Pearson correlation test.
Results: According to the results, the majority of participants were in the age range of 30 to 35 years, the mean score of leadership style was 86.75 that was high. The mean score of positive organizational behavior was 79.23 that was high, and the mean score of stress of COVID19 was 7.23 that was low. The mean score of leadership style in all cases was positively and significantly correlated with the score of positive organizational behavior (r=0.322, P<0.001) and inversely correlated with the score of stress of COVID-19 (r=-0.314, P<0.001). Also, the mean score of positive organizational behavior was inversely correlated to the score of stress of COVID19 (r=-0.374, P<0.001).
Conclusion: Positive organizational behavior was at a high level in the staff of Shahrekord health centers during the Corona pandemic. The participatory leadership style was more considered, and had a negative relationship with the stress of Covid-19. Therefore, it seems that it will be possible to establish a correct management style and positive organizational behavior by reducing the stress of Covid-19.
A Study of Domestic Violence against Married Women in Afghanistan: Grounded Theory
Authors: Jafari Hussain , Zareei Mahmoodabadi Hassan , Naderi Nobandegani Zahra 
Published: June 2022

Background: Domestic violence against women is currently one of the most important and characteristic forms of violence against human rights, which is associated with negative psychological and physical health consequences. The persistence of domestic violence causes marital incompatibility and has countless consequences for women. The aim of this study was to investigate domestic violence against married women in Bamyan province (Afghanistan).
Methods: This research was conducted using the qualitative method and grounded theory. The study population included all women with domestic violence in Bamyan province in 2019. Convenience and snowball sampling were used to achieve theoretical saturation. Those women who were eligible for the study were given in-depth semi-structured interviews, and finally 12 women were selected. The data were analyzed using Strauss and Corbin method with three stages of open, axial, and selective coding.
Results: In this study, 297 concepts, 31 categories, 15 sub-categories, and 5 main categories including cultural poverty, personality problems and husband’s irresponsibility, panic, women's awakening, and low self-esteem were extracted. Also, all these 5 main categories were represented as a sub-category of "home terrorism".
Conclusions: Although women in Bamyan are still victims of domestic violence, increasing women's awareness and education in this field have been able to make women safe to some extent.