bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTASI KEBIJAKAN PEMERINTAH KOTA CIREBON DALAM MENINGKATKAN KETERTIBAN PEDAGANG KAKI LIMA (Studi Kasus di Jl. Siliwangi Kota Cirebon)
Authors: Mirnawati Winda , Agustina Heriyani , Nariyah Hery 
Published: July 2022

ABSTRACT Street Vendors is a very complicated thing to ensure order. This became the basic tasks of municipal government in particular Cirebon Civil Service Police Unit to regulate street vendors, economic needs urgent that makes the street vendors sell on the road or on the sidewalk which should be forbidden by the local government area. The problem that arises if the implementation of policies regulating street vendors in the city of Cirebon can be increased in accordance with local regulations No. 9 of 2003 on Public Order policy on public order policy on public order by the local governments aimed so the vendors are supposed to walk not violate so as to create (Health, Beauty, and Order)The method used is qualitative research informant with the chairman of the peace and public order agencies Civil Service Police Unit Cirebon city and street vendors on the sidewalks and on the road in Jalan Siliwangi Cirebon City. Techniques of data collection using interviews, observation, data analysis, and data validity.Research results show that Control Policy Implementation street vendors in the city of Cirebon (status cases Jl. Siliwangi) is not optimal it is still a lot of problems including lack of regulatory policy on regulating local street vendors. Theories are taken using the theory of Van Meter and Van Horn include the size and purpose of the policy, resources, characteristics of the implementing agencies, communication between relevant organizations and implementing activities, social environment, political economy which is still unresolved due to the limited quality and quantity of the resources, the means, and infrastructure support order is not optimal.
IMPLEMENTASI KEBIJAKAN JAMINAN PERSALINAN (JAMPERSAL) DI PUSKESMAS BALIDA KECAMATAN DAWUAN KABUPATEN MAJALENGKA
Authors: Kusumah Yusup Juniar , Sutarjo Moh , Bharoto RM Haryo 
Published: July 2022

AbstrakPenelitian ini didasarkan pada fenomena adanya kendala dalam impelementasi kebijakan Jampersal di Kecamatan Dawuan Kabupaten Majalengka. Penelitian ini di laksanakan di Puskesmas Balida Kecamatan Dawuan Kabupaten Majalengka, dimana Puskesmas Balida merupakan Puskesmas yang mengepalai 11 (sebelas) Desa di Kecamatan Dawuan Kabupaten Majalengka dengan dilengkapi fasilitas ruang rawat inap bersalin. Tujuan dari penelitian ini untuk mengetahui implementasi kebijakan Jaminan Persalinan (JAMPERSAL) pada Puskesmas Balida Kecamatan Dawuan Kabupaten Majalengka.Penelitian ini menggunakan metode penelitian kualitatif deskriptif. Teori yang digunakan adalah EDWARD III dimana terdapat beberapa faktor yang mempengaruhi implementasi kebijakan publik yaitu Komunikasi, Sumber Daya, Disposisi/Sikap, dan Struktur Birokrasi.Teknik pengambilan sampel dilakukan dengan menggunakan pusposive sampling. Teknik pengumpulan data dilakukan dengan cara observasi, wawancara dan menganalisa data pada arsip dan dokumentasi foto kegiatan pelayanan Jaminan Persalinan di Puskesmas Balida Kecamatan Dawuan Kabupaten Manjalengka.Hasil dari pengamatan ini, pelaksanaan program Jampersal di Puskesmas Balida sesuai tujuan yaitu cakupan pelayanan terhadap masyarakat khususnya ibu hamil, kendala dalam program Jampersal yaitu tidak adanya sosialisasi secara khusus terhadap masyarakat terutama ibu hamil.Kesimpulan hasil penelitian ini secara keseluruhan adalah pelaksanaan program Jaminan Persalinan (JAMPERSAL) di Puskesmas Balida Kecamatan Dawuan Kabupaten Majalengka belum tercapai secara optimal. Hal ini dapat dilihat dari masih banyaknya masyarakat di Kecamatan Dawuan Kabupaten Majalengka yang tidak menggunakan jaminan persalinan karena ketidaktahuan adanya program jaminan persalinan.
PERBANDINGAN PRODUKTIVITAS KERJA PEGAWAI NEGERI SIPIL DENGAN PEGAWAI BADAN USAHA MILIK NEGARA (Studi Komparasi di Sekretariat Daerah Kota Cirebon dengan PT. Kereta Api Indonesia (Persero) Daerah Operasi III Cirebon)
Authors: Nahdiyyah Iim Rohimatun , Hidayat Moh Taufik , . Nursahidin 
Published: July 2022

Abstrak Judul Skripsi adalah “Perbandingan Produktivitas Kerja Pegawai Negeri Sipil dengan Pegawai Badan Usaha Milik Negara (Studi Komparasi di Sekretariat Kota Cirebon dengan PT. Kereta Api Indonesia (Persero) Daerah Operasi III Cirebon. Masalah yang penulis kemukakan adalah rendahnya produktivitas kerja Pegawai Negeri Sipil di Kota Cirebon dibandingkan dengan Pegawai Badan Usaha Milik Negara di PT. Kereta Api Indonesia (Persero) Daerah Operasi III Cirebon. Hal ini terlihat dari indikasi dalam menyelesaikan pekerjaan sering mengalami kesalahan dan seringnya terjadi keterlambatan dalam pembuatan laporan. Hipotesis penelitian yang penulis ajukan adalah adanya perbedaan yang signifikan antara produktivitas kerja Pegawai Negeri Sipil di Sekretariat Daerah Kota Cirebon dengan Pegawai Badan Usaha Milik Negara di PT. Kereta Api Indonesia (Persero) Daerah Operasi III Cirebon. Metode penelitian yang penulis gunakan adalah menggunakan metode penelitian kombinasi yaitu dengan mengkombinasikan atau menggabungkan antara metode penelitian kuantitatif dengan metode kualitatif, adapun model kombinasi yang penulis gunakan adalah model penelitian Concurrent Trianguation Strategy yaitu dengan menggunakan metode kuantitatif dan kualitatif secara bersama-sama, baik dalam pengumpulan data maupun analisanya, kemudian membandingkan data yang diperoleh sehingga dapat di temukan mana data yang dapat dibandingkan dan dibedakan. Hasil Penelitian membuktikan bahwa produktivitas kerja baik kerja Pegawai Negeri Sipil di Sekretariat Daerah Kota Cirebon maupun Pegawai Badan Usaha Milik Negara di PT. Kereta Api Indonesia (Persero) Daerah Operasi III Cirebon masih belum optimal, dimana keberhasilannya baru mencapai pada tingkatan yang cukup baik. Total skor produktivitas kerja Pegawai Negeri Sipil di Sekretariat Daerah adalah sebesar 2210 atau 53,1 % sedangkan total skor produktivitas kerja Pegawai Badan Usaha Milik Negara di PT. Kereta Api Indonesia (Persero) Daerah Operasi III adalah sebesar 2692 atau 65.7 %. Terdapat perbedaan yang signifikan antara produktivitas kerja Pegawai Negeri Sipil di Sekretariat Daerah Kota Cirebon dengan Pegawai Badan Usaha Milik Negara di PT. Kereta Api Indonesia (Persero) Daerah Operasi III Cirebon dengan signifikasi sebesar 0,000 atau ≥ (kurang dari ) 0,05. Nilai rata-rata produktivitas kerja Pegawai Negeri Sipil di Sekretariat Daerah Kota Cirebon adalah sebesar 34,52 sedangkan nilai rata-rata produktivitas kerja Pegawai Badan Usaha Milik Negara di PT. Kereta Api Indonesia (Persero) Daerah Operasi III Cirebon adalah sebesar 42,76. Hipotesis yang penulis ajukan adalah Ho ditolak. dengan kata lain H1 diterima atau H1 benar. Maka dapat disimpulkan bahwa hasil penelitian diterima dan benar.
How do students learn German cultural values throughout podcast-mediated project-based learning AMIDST COVID-19 pandemic?
Authors: Santoso Iman 
Published: July 2022

Kulturkunde, a Germany intercultural class, pivoted to online learning due to Covid-19. Meetings switched from face-to-face to synchronous and asynchronous meetings. During these modes, students struggled learning Germany cultures throughout the podcast-mediated project-based learning. Accordingly, the paper attempts to describe how Germany-majored students learn Germany cultures during the online learning. Data were garnered from the Kulturkunde class reflection during podcast-mediated project-based learning in the state university in Yogyakarta. During these online meetings, twelve podcasts containing students’ intercultural projects were published. The findings reveal the students successfully pursued varieties of intercultural awareness. In addition, they also promote their language fluency and accuracy. To end, issues of ICT-based learning is also sought to discuss. Kulturkunde, pembelajaran budaya Jerman berubah dari tatap mukan menjadi tatap maya. Melalui kanal ini, mahasiswa berusahan keras belajar dan memahami nilai-nilai budaya Jerman secara daring melalui bantuan media podcast. Dari sini, tujuan penulisan artikel untuk mendeskripsikan bagaimana mahasiswa jurusan pendidikan bahasa Jerman berlajar budaya Jerman secara daring. Data riset diperoleh melalui kegiatan refleksi selama pembelajaran yang didokumentasikan selama pembealjaran oleh dosen di sebuah universitas negeri di Yogyakarta, Indonesia. Selama kegiatan pembealjaran daring ini, dua belas proyek podcast berhasil dipublikasikan. Hasil riset menunjukkan tidak hanya masalah perolehan nilai-nilai budaya Jerman yang diperoleh dan dipelajari, namun juga adanya kemampuan berbahasa Jerman yang meningkat. Sebagai tambahan, kemampuan pengguanaan teknologi pendidikan juga menjadi berkembang. Kata Kunci: budaya Jerman, kulturkunde, proyek kelas, Podcast
Design, Synthesis, and Bioactivities of Novel Trifluoromethyl Pyrimidine Derivatives Bearing an Amide Moiety
Authors: Lan Wenjun , Tang Xuemei , Yu Jia , Fei Qiang , Wu Wenneng , Li Pei , Luo Heng 
Published: July 2022

Twenty-three novel trifluoromethyl pyrimidine derivatives containing an amide moiety were designed and synthesized through four-step reactions and evaluated for their antifungal, insecticidal, and anticancer properties. Bioassay results indicated that some of the title compounds exhibited good in vitro antifungal activities against Botryosphaeria dothidea (B. dothidea), Phompsis sp., Botrytis cinereal (B. cinerea), Colletotrichum gloeosporioides (C. gloeosporioides), Pyricutaria oryzae (P. oryzae), and Sclerotinia sclerotiorum (S. sclerotiorum) at 50 μg/ml. Meanwhile, the synthesized compounds showed moderate insecticidal activities against Mythimna separata (M. separata) and Spdoptera frugiperda (S. frugiperda) at 500 μg/ml, which were lower than those of chlorantraniliprole. In addition, the synthesized compounds indicated certain anticancer activities against PC3, K562, Hela, and A549 at 5 μg/ml, which were lower than those of doxorubicin. Notably, this work is the first report on the antifungal, insecticidal, and anticancer activities of trifluoromethyl pyrimidine derivatives bearing an amide moiety.
Effect of electrophysiological mapping on non-transmural annulus ablation and atrial fibrillation recurrence prediction after 6 months of Cox-Maze IV procedure
Authors: Sun Zhishan , Fan Chengming , Song Long , Zhang Hao , Jiang Zenan , Tan Haoyu , Sun Yaqin , Liu Liming 
Published: July 2022

ObjectiveThe objective of this study was to observe the safety and efficacy of electrophysiological mapping following the Cox-Maze IV procedure and to investigate whether a correlation exists between recurrence of atrial fibrillation (AF) with the completeness of bidirectional electrical isolation and the inducibility of AF immediately after the Cox-Maze IV procedure.MethodsTotally, 80 consecutive patients who suffered from aortic valve or mitral valve disease and persistent AF were randomly enrolled into the control group and electrophysiological mapping following the Cox-Maze IV group (Electrophysio-Maze group). In the Electrophysio-Maze group, patients underwent concomitant Cox-Maze procedure and following electrophysiological mapping of ablation lines in mitral isthmus, left atrial “box,” and tricuspid annulus. If the bidirectional electrical isolation of tricuspid annulus ablation line is incomplete, whether to implement supplementary ablation will be independently decided by the operator. Before and after the Cox-Maze IV procedure, AF induction was performed. All patients in both groups were continuously followed-up and underwent electrocardiogram Holter monitoring after 6 months.ResultsIn total, 42 Electrophysio-Maze patients and 38 controls were enrolled. Compared with patients in the control group, there were shorter hospital stay, better cardiac remodeling changes, and higher relief from AF during the follow-up period of 6 months in the Electrophysio-Maze group. Within the Electrophysio-Maze group, the rate of incomplete the bidirectional electrical isolation of “box” ablation lines was zero, and the rate of incomplete bidirectional electrical isolation of mitral isthmus ablation line or tricuspid annulus ablation line was 23.8%. After two cases of successful complementary ablation on the tricuspid annulus ablation line, the final incomplete bidirectional electrical isolation of annulus ablation lines was 19.0%. There were correlations between late AF recurrence after 6 months with incomplete bidirectional electrical isolation of annulus ablation lines and AF induction immediately after the Cox-Maze IV procedure.ConclusionElectrophysiological mapping following the Cox-Maze procedure is safe and effective. Electrophysiological mapping in the Cox-Maze procedure can find out the non-transmural annulus ablation lines by assessing the completeness of bidirectional electrical isolation of ablation lines, guide supplementary ablation, and predict AF recurrence after 6 months.
Impact of the Salt Concentration and Biophysical Cohesion on the Settling Behavior of Bentonites
Authors: Krahl Ellen , Vowinckel Bernhard , Ye Leiping , Hsu Tian-Jian , Manning Andrew J. 
Published: July 2022

The flocculation behavior of clay minerals in aquatic environments is an important process in estuarine and riverine dynamics, where strong gradients in salinity can locally occur. Various contradicting observations have been reported in the literature on the impact of salt concentration on the settling process of cohesive sediments. To address this issue in a systematic manner, we investigate the settling behavior of clay minerals as a function of the salt concentration of the ambient water. Specifically, we focus on montmorillonite as a prototype clay mineral with a high cation exchange capacity (CEC). To this end, we study suspensions of Wyoming bentonite (Volclay SPV) as a very important constituent for many constructional and industrial purposes. We perform an experimental campaign to study the settling behavior of moderately turbid montmorillonite concentrations in monovalent salt solutions with different salinities (sodium chloride) to represent different environments ranging from deionized to ocean water, respectively. The subsequent settling process was monitored by taking pictures by a camera in regular time intervals over a total observation time up to 48 h. In addition, a modified hydrometer analysis is conducted to determine the grain size distribution (in terms of an equivalent diameter) of the flocculated clay suspension in salt water. Despite the rather high cation exchange capacity of the investigated clay (CEC=88.1), our results show that the settling speed drastically increases within a range of 0.6–1.0 PSU and stays approximately constant for higher salinities. This critical salt concentration is defined here as the critical coagulation concentration (CCC) and lies well below the salinity of natural open water bodies. The hydrometer analysis revealed that 60% of the agglomerates exceed the equivalent grain size of 20 μm. Finally, the findings of this study are supplemented with experiments studying the effect of Extracellular Polymeric Substances (EPS) on the flocculation behavior of bentonite in salt water. Our results demonstrate that salinity is the original trigger for flocculation, whereas EPS allows for even larger floc size but it does not play a significant role for the settling processes of bentonite in estuarine environments.
Outcomes of nonsuspicious contralateral nodules with active surveillance after lobectomy in patients with papillary thyroid carcinoma
Authors: Huang Hui , Liu Jie , Wang Xiaolei , Liu Shaoyan 
Published: July 2022

ObjectiveTo observe the outcomes of nonsuspicious contralateral nodules with active surveillance in patients with papillary thyroid carcinoma (PTC).Methods4pt?&gt;Consecutive patients who underwent lobectomy for PTC were retrospectively reviewed. Patients with one or more nodules with nonsuspicious ultrasonography (US) features in the contralateral lobe were included.ResultsTwo hundred and eighty-three patients were included. All patients underwent thyroid lobectomy with ipsilateral prophylactic central neck dissection. A total of 123 patients (43.5%) were classified as ATA low-risk, and 160 patients (56.5%) were classified as intermediate-risk. The median size of the contralateral nodules was 3 mm (range, 2 to 16 mm). After a period of follow-up, the median size change of contralateral nodules was 0 mm (range, -7 to 8 mm). Eight patients (2.8%) had nodule growth &gt;3 mm, 223 patients (78.8%) had stable or decreased nodules, and 52 patients (18.4%) had no detectable nodules. Nodules in 24 patients had suspicious US features, 16 of which were diagnosed with PTMC by either cytology after FNA (in 7 patients) or histopathology after completion thyroidectomy (in 9 patients). Another four patients received completion thyroidectomy for ipsilateral cervical lymph node metastasis. The 5-year residual lobe recurrence (RLR) rate and recurrence-free survival (RFS) rate were 7.4% and 89.8%, respectively. Multivariate analysis showed that multifocality and ATA intermediate-risk were independent predictors for RLR (HR4.083, 95%CI 1.480-11.261, P = 0.007; HR 6.045, 95%CI 1.370-26.662, P = 0.017, respectively) and RFS (HR 5.240, 95%CI 2.114-12.991, P &lt; 0.001; HR 5.223, 95%CI 1.353-17.765, P = 0.008, respectively).ConclusionsActive surveillance for nonsuspicious contralateral nodules in patients with low-risk and selected intermediate-risk PTC is safe. Multifocality and ATA intermediate-risk are predicters for recurrence. Early detection and salvage surgery are effective.
Analysis on Emergency Treatment Effect of Tritium Leakage Accident in the Nuclear Reactor Under Different Ventilation Conditions
Authors: Li Changjun , Cai Xingfu , Xiao Mingqing , Huo Yonggang , Xu Peng , Li Sufen 
Published: July 2022

The high-pressure tritium leakage is a typical nuclear leakage accident, which can cause radioactive harm. The study aims at the tritium leakage problem in the high-pressure vessel of a nuclear reactor, installing a typical tritium leakage scenario and establishing the thermodynamic model of tritium leakage behavior which describes the transient process of tritium leakage. To analyze the effect of different ventilation scenes on tritium removal efficiency, the study sets up six different ventilation scenes and carries out the numerical simulation of tritium migration and mixing behavior based on Fluent. The result shows that different ventilation scenes will form different swirl distributions; the more complex the swirl distribution is, the faster the tritium concentration decreases. The shortest time required to decrease tritium concentration in space to the background level at the ventilation rate of 1 m3 s−1 is about 830 s and the longest time is about 1100 s. The overall tritium removal efficiency can be effectively improved when the swirl concentration distribution area is opposite to the exhaust outlet position. The setting method of ventilation is optimized, which provides technical support for the emergency treatment of tritium leakage accidents in the room.
High expression of ZFP36L2 correlates with the prognosis and immune infiltration in lower-grade glioma
Authors: Zhou Min , Li Jinquan , Chen Cheng 
Published: July 2022

Background: The ZFP36 Ring Finger Protein Like 2 (ZFP36L2) is an RNA-binding protein that regulates gene expression at post-transcriptional level. However, the clinical significance and prognostic value of ZFP36L2 in lower-grade glioma (LGG) remain unclear.Method: ZFP36L2 expression was investigated using public datasets and the prognostic merit of ZFP36L2 with LGG patients was further evaluated. The correlation between the genetic alteration of ZFP36L2 and its mRNA expression was accessed via cBioPortal. Additionally, the prognostic value of the ZFP36L2 methylation levels in LGG was evaluated by MethSurv. The potential biological role of ZFP36L2 in LGG was identified by performing functional analyses. We also examined the correlation between ZFP36L2 expression and the immune infiltration. Finally, the predictive value of ZFP36L2 to immunotherapy was assessed.Result: ZFP36L2 was highly expressed in LGG patients and overexpressed ZFP36L2 predicted poor clinical outcomes. We further identified ZFP36L2 as an independent prognostic factor. The methylation level of ZFP36L2 negatively correlated with the ZFP36L2 expression, and patients with low ZFP36L2 methylation had worse overall survival. The results of functional analysis indicated that ZFP36L2 was involved in multiple immune response-related pathways in LGG. Furthermore, high expression of ZFP36L2 was significantly and positively correlated with immune infiltration. Finally, we found that ZFP36L2 expression was positively correlated with the immune checkpoint PD-L1, and ZFP36L2 low expression cohort gained better benefit from immunotherapy.Conclusion: Our findings demonstrate that ZFP36L2 is a potential biomarker for LGG, highlighting its potential as a therapeutic target in immunotherapy.
A causal relationship between leukocyte telomere length and multiple sclerosis: A Mendelian randomization study
Authors: Liao Qiao , He Jian , Tian Fa-Fa , Bi Fang-Fang , Huang Kun 
Published: July 2022

ObjectivesMultiple sclerosis (MS) is a chronic inflammatory autoimmune and degenerative disorder of the central nervous system. Telomeres are protective structures located at the ends of linear chromosomes, and leukocyte telomere length (LTL) is closely connected with cell aging and senescence. However, the relationship between LTL and the risk of MS remains unknown.MethodsWe performed a two-sample Mendelian randomization (MR) to evaluate whether LTL was causally associated with MS risk.ResultsIn our MR analysis, 12 LTL-related variants were selected as valid instrumental variables, and a causal relationship between LTL and MS was suggested. The risk of MS nearly doubled as the genetically predicted LTL shortened by one standard deviation (SD) under the inverse variance weighted (IVW) fixed effect model (odds ratio (OR) = 2.00, 95% confidence interval (CI): 1.52-2.62, p = 6.01e-07). Similar estimated causal effects were also observed under different MR models. The MR–Egger regression test did not reveal any evidence of directional pleiotropy (intercept = -0.005, stand error (SE) = 0.03, p = 0.87). The Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) analysis also indicated no directional pleiotropy or outliers for any LTL-related IVs (p-global test = 0.13). In addition, a leave-one-out sensitivity analysis showed similar findings, which further emphasized the validity and stability of the causal relationship.ConclusionsOur results suggest a potential causal effect of LTL on the risk of MS. Genetically predicted shorter LTL could increase the risk of MS in the European population. LTL should be noted and emphasized in the pathogenesis and treatment of MS.