bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical Photometry of WR140 as the Dust Formed During the 2016 Periastron Passage
Authors: Peatt Megan J. , Richardson Noel D. 
Published: January 2022

Abstract
The colliding wind binary WR140 produces dust in its shocked gas every periastron passage. While the infrared light curve is very repeatable, there are noticeable changes every cycle in the optical time-series photometry. In the phases following periastron, there are optical dips in the light curve that were postulated to be caused by localized clumps in the dust produced in our line of sight. We report on the B- and V-band light curves that were recorded by the American Association of Variable Star Observers after the 2016 periastron event and briefly discuss comparisons to geometric models of the dust production to infer that these features are likely caused by localized dust clumps in the new dust shell.
Disk Material Inflates Gaia RUWE Values in Single Stars
Authors: Fitton Shannon , Tofflemire Benjamin M. , Kraus Adam L. 
Published: January 2022

Abstract
An understanding of the dynamical evolution of binary star systems, and their effects on stellar and planetary evolution, requires well-characterized binary populations across stellar ages. However, the observational resources required to find and characterize binaries are expensive. With the release of high-precision Gaia astrometry, the re-normalized unit weight error (RUWE) statistic has been shown to reveal the presence of binary systems, with RUWE values greater than 1.2 indicating the presence of a stellar companion within ∼1″. Our goal is to assess whether this new diagnostic, which was developed for field-age systems (>1 Gyr), applies to young systems; specifically, those that host circumstellar disks. With a control sample of single-star systems, compiled from high-contrast imagining surveys of the Taurus and Upper Scorpius star-forming regions, we compare the RUWE values for systems with and without circumstellar disks. We show that the presence of a protoplanetary disk alone can result in inflated RUWE values. Based on the distribution of the RUWE for disk-bearing single stars, we suggest a more conservative single-star—binary threshold is warranted in the presence of disk material. We place this cutoff at the distribution’s 95th percentile, with RUWE = 2.5.
Small interfering RNAs targeting agrA and sarA attenuate pathogenesis of Staphylococcus aureus in Caenorhabditis elegans
Authors: Thompson Terissa Alexas , Brown Paul Dean 
Published: January 2022

Introduction: The use of small interfering RNA (siRNA) gene silencing is a promising therapeutic option as it does not impose selective pressure on bacteria that is often associated with the development of resistance. The study assessed the effect of siRNA targeted to sarA and agrA in S. aureus and the relationship between the transcriptional response, biofilm formation and pathogenicity.
Methodology: siRNAs designed against agrA and sarA were electroporated into methicillin-resistant and methicillin-susceptible S. aureus strains. mRNA levels, growth kinetics, biofilm formation and minimal inhibitory concentration were measured. Efficacy of siRNA in bacteria was assessed using survival assays in a C. elegans model. Differences in gene expression before and after siRNA treatment were anaysed using the paired t-test, while the log rank test was used to assess the significance of any difference among survival rates of nematodes.
Results: Biofilm formation decreased significantly in siRNA treated strains and growth rates of siRNA treated strains were significantly higher compared to untreated strains. We observed significant decreases in the transcriptional response in siRNA treated strains, with concomitant significant increases in the lifespan of C. elegans worms exposed to siRNA-treated versus untreated strains.
Conclusions: siRNA targeted to agrA and sarA lowered mRNA transcription and pathogenicity of S. aureus.
Salmonella Schwarzengrund, Akuafo, and O:16 isolated from vacuum-packaged beef produced in the state of Mato Grosso, Brazil
Authors: Muller Barbara , Cunha-Neto Adelino , Castro Vinicius Silva , Carvalho Ricardo Cesar Tavares , Carvalho Teixeira Larrayane Albuês , Rodrigues Dalia dos Prazeres , De Souza Figueiredo Eduardo Eustáquio 
Published: January 2022

Introduction: Salmonella spp. is a pathogen associated with foodborne infections, mainly in foods of animal origin. In this context, the present study investigated the occurrence of Salmonella serotypes, genotypes and the antimicrobial resistance profiles of strains in fresh beef produced in Mato Grosso, Brazil.
Methodology: A total of 107 samples from 13 different slaughterhouses in the Mato Grosso were analyzed. Suggestive Salmonella spp. colonies detected during the biochemical screening were submitted to DNA extraction, and hilA gene amplification was used for the PCR reaction. Antimicrobial resistance analyses were performed using 17 antimicrobial agents from eight different classes by the disk diffusion method. Strains exhibiting multiple drug resistances were submitted to PCR genotyping based on repetitive sequences (rep-PCR), using a commercial semiautomatic DiversiLab® system.
Results: A total of 5.6% (6/107) of the samples tested positive by the conventional method and were confirmed by PCR, namely two S. Akuafo, two non-typable Salmonella enterica strains, one Salmonella O:16 serovar, and one S. Schwarzengrund. The antimicrobial resistance profiles indicated resistance to gentamicin (30%), tetracycline, nitrofurantoin, and trimethoprim + sulfamethoxazole (16%). Genotyping indicated a 70% difference between S. Schwarzengrund and the non-typable Salmonella strains. No genetic similarities were observed between the six Salmonella isolates based on rep-PCR, including two S. Akuafo.
Conclusions: The results obtained herein corroborate that Salmonella serovar Schwarzengrund is commonly isolated in animal products in the state of Mato Grosso, Brazil, also highlighting the presence of two unusual Salmonella serovars in beef (Akuafo and O:16).
Framing the Feminised Home-Based Services Sector at European Level: the Evolving Role of Trade Unions and Employer’s Organisations
Authors: Ledoux Clémence 
Published: January 2022

Les services à domicile -dans lesquels les femmes des classes populaires constituent la majorité de la main-d'œuvre- sont arrivés sur l'agenda européen dans les années 1990. Depuis lors, l'attention des institutions européennes s'est concentrée sur deux questions principales : la participation au marché du travail et les droits humains et des travailleuses. Quel a été le rôle des représentants des travailleuses 1 et des employeurs dans l'émergence et le façonnement au niveau européen de ce nouveau domaine d'intérêt ? Cet article montre que les fédérations patronales nationales et européennes ont coopéré avec la Commission européenne pour présenter le travail à domicile comme un moyen d'augmenter les taux d'emploi, mais que d'autres façons de penser ces services sont également apparues. Les activités de l’organisation internationale du travail (OIT) ont contribué à développer des convergences des cadrages différents du problème au niveau européen.
L’action en contrefaçon comme « arme de domination »
Authors: Siiriainen Fabrice 
Published: January 2022

B. Remiche a souvent dénoncé des usages dévoyés de l’action en contrefaçon utilisée comme une « arme de domination » commerciale. Ce phénomène, loin d’être marginal, est sûrement sous-estimé et difficilement appréhendable par la pratique en raison de l’état du droit de la propriété intellectuelle qui, au contraire, est de nature à l’encourager. Le présent article présente cette problématique et envisage quelques pistes pour mieux lutter à l’avenir contre ce type d’abus, la première étape résidant dans sa prise de conscience.
La santé publique mérite mieux
Authors: Vivant Michel 
Published: January 2022

La récente pandémie qui s’est abattue sur la planète a réactivé le débat récurrent sur les rapports à établir entre brevet et santé publique. L’éventuelle « levée » des brevets, défendue par certains, est pleine d’ambiguïté. Il faut en revanche reconsidérer la licence d’office dans l’intérêt de la santé publique, pour tout à la fois lui donner une réalité et la rendre aussi efficace que possible.
L’actionnaire est-il recevable à introduire une action en justice pour un préjudice subi par la société ?
Authors: Philippe Denis 
Published: January 2022

Lorsqu’il est porté atteinte au patrimoine d’une société, l’action en réparation qui résulte de ce dommage appartient à cette société et à son organe compétent. Quid es actionnaires ? Ceux-ci ne disposent pas d’un droit d’action autonome en réparation d’un préjudice collectif causé au patrimoine de la société. Ils ne peuvent agir que pour obtenir réparation d’un préjudice personnel et distinct de celui subi par la société. La perte de dividende ne constitue pas un préjudice propre. Les mêmes règles s’appliquent en cas d’abus de majorité.
L’architecture interstitielle des Mémoires
Authors: Baty-Delalande Hélène 
Published: January 2022

L’étude du récit de genèse que comportent, en leurs marges, les volumes des Mémoires de Beauvoir et l’analyse des campagnes d’écriture successives dont témoignent les avant-textes qui subsistent permettent de saisir un processus de composition complexe, qui estompe et redistribue ces fragments apparaissant d’abord comme des jalons réflexifs de l’écriture de soi. L’estompage du récit de genèse ou des moments de ressaisie réflexive du geste mémoriel peut être compris comme une manière de garantir la fluidité, la cohésion et la force d’évidence du récit récapitulatif. Ce qui subsiste n’est cependant pas à considérer comme un résidu : disposés aux différents seuils du récit, à ses interstices, les moments réflexifs contribuent alors à mettre en ordre le passé.
Appendix | Attracting Highly Skilled Migrants to Guangzhou, China: A Policy Commentary
Authors: Li Wei , Ma Ling , Tan Yining , Liu Meixin 
Published: January 2022

Appendix to the chapter Wei Li, Ling Ma, Yining Tan and Meixin Liu (2022) Attracting Highly Skilled Migrants to Guangzhou, China: A Policy Commentary, International Development Policy | Revue internationale de politique de développement 14 | 2022, URL: http://journals.openedition.org/poldev/4825
Variegated Outcomes of T Cell Activation by Dendritic Cells in the Steady State
Authors: Bourque Jessica , Hawiger Daniel 
Published: January 2022

Abstract
Conventional dendritic cells (cDC) control adaptive immunity by sensing damage- and pathogen-associated molecular patterns and then inducing defined differentiation programs in T cells. Nevertheless, in the absence of specific proimmunogenic innate signals, generally referred to as the steady state, cDC also activate T cells to induce specific functional fates. Consistent with the maintenance of homeostasis, such specific outcomes of T cell activation in the steady state include T cell clonal anergy, deletion, and conversion of peripheral regulatory T cells (pTregs). However, the robust induction of protolerogenic mechanisms must be reconciled with the initiation of autoimmune responses and cancer immunosurveillance that are also observed under homeostatic conditions. Here we review the diversity of fates and functions of T cells involved in the opposing immunogenic and tolerogenic processes induced in the steady state by the relevant mechanisms of systemic cDC present in murine peripheral lymphoid organs.
Minimal Information about MHC Multimers (MIAMM)
Authors: Vita Randi , Mody Apurva , Overton James A , Buus Soren , Haley Stephen T , Sette Alessandro , Mallajosyula Vamsee , Davis Mark M , Long Dale L , Willis Richard A , Peters Bjoern , Altman John D 
Published: January 2022

Abstract
With the goal of improving the reproducibility and annotatability of MHC multimer reagent data, we present the establishment of a new data standard: Minimal Information about MHC Multimers (https://miamm.lji.org/). Multimers are engineered reagents composed of a ligand and a MHC, which can be represented in a standardized format using ontology terminology. We provide an online Web site to host the details of the standard, as well as a validation tool to assist with the adoption of the standard. We hope that this publication will bring increased awareness of Minimal Information about MHC Multimers and drive acceptance, ultimately improving the quality and documentation of multimer data in the scientific literature.
Comparison of the Conservative Approach with Ureteral Stent Implantation in Treating Hydronephrosis during Pregnancy
Authors: Balıkoğlu Meriç , Bayraktar Burak , Özsoy Çağatay , Kanmaz Ahkam Göksel , Özeren Mehmet 
Published: January 2022

Objectives:
Physiological and anatomical changes in the urinary system are expected in pregnancy. Therefore, uretero-hydronephrosis is observed in pregnant women in the second trimester. In this study, it was aimed to investigate the effect of ureteral double J stenting (DBJ) on perinatal outcomes and maternal urinary system values in order to decrease fetal and maternal morbidity of maternal hydronephrosis.

Materials and Methods:
Sixty-three pregnant women included in the study are split into two groups: 44 were administered conservative pain palliation (non-DBJ group/control) and 19 were implanted with a ureteral double J stent (DBJ group/case). Renal functions were evaluated using blood urea nitrogen (BUN) and creatinine levels. The presence of inflammation and infection was investigated using white blood cell (WBC) count, WBC in urine, nitrite presence, and growth in urine culture. The week hydronephrosis began and fetal birth weight and date were scanned.

Results:
There were no statistically significant difference between two groups leucocite, erythrocyte in urine, growth in urine culture, nitrite positivity indicated, and creatinine levels (P > 0.05, for all). BUN values were significantly lower in the DBJ group (P = 0.005). The prevalence of WBC in urine was statistically significantly higher in the DBJ group (P = 0.02). The week of birth was statistically significantly lower in the DBJ group than that in the non-DBJ group (36 ± 2 vs. 37.6 ± 3, P = 0.01).

Conclusion:
Our study suggests that implantation of a DBJ to patients who do not respond to conservative hydronephrosis treatment does not decrease the possibility of preterm birth and low birth weight.
Assessment of Neutrophil/Lymphocyte Ratio in Relation to Presentation and Prognosis of Diffuse Large B-Cell Nonhodgkin Lymphoma
Authors: Al-Tameemi Waseem F. , Mahmmood Ahmed Jaber 
Published: January 2022

BACKGROUND:
Diffuse large B-cell lymphoma (DLBCL) is representing 30%–40% of all lymphomas. It is an aggressive lymphoma with heterogeneous clinicopathological features. Inflammatory processes have been identified to play an important role in the pathogenesis of lymphoma including the neutrophil-lymphocyte ratio (NL ratio) was associated with a poor prognosis.

AIM OF STUDY:
The aim of this study is to assess neutrophil/lymphocyte (N/L) ratio in relation to clinical presentation, and other prognosticators in DLBCL, and to study the effect of these markers with response rate and early outcome.

PATIENTS AND METHODS:
This is a cohort prospective study with data obtained from May 2018 to November 2019. Data collected from multiple hematological centers in Baghdad, Iraq. A total of 58 adult patients who are newly diagnosed with DLBCL were enrolled. In addition to demographic features, international prognostic index (IPI) score, complete blood parameters (white blood cell count, N/L ratio, had assessed.

RESULTS:
The mean age was 53.54 ± 14.95 years. Twenty-two (45.83%) had extranodal involvement at the presentation. Advanced stage was reported in 34 (70.83%). Median N/L ratio was 3.39 with cut-off values 4.41. There was no significant association with the N/L ratio neither with progression-free survival (PFS) nor with the advanced stage presentation (P = 0.238, 0.343, respectively). It is found also that higher median N/L ratio was significantly associated with high and high-intermediate IPI score (P = 0.03).

CONCLUSION:
The NL ratio has a significant association with the IPI score, but not with the disease PFS.
Медичне забезпечення Збройних Сил України у контексті трансформації суспільної охорони здоров’я: нормативно-правові аспекти
Authors: Zhakhovsky V. O. , Livinskyi V. G , Ostaschenko T. M. , Ivanko O. M. , Vasiuk N. O. 
Published: January 2022

Мета роботи – аналіз законодавчої і нормативно-правової бази суспільної охорони здоров’я України та дослідження її впливу на медичне забезпечення Збройних Сил (ЗС) України.
Матеріали та методи. Використано законодавчі та нормативно-правові акти з питань охорони здоров’я в Україні, публікації у відкритих наукових джерелах. Методи дослідження: бібліографічний, аналітичний, системного підходу.
Результати. Встановлено, що стан охорони здоров’я в Україні потребує радикальних змін, зокрема в частині удосконалення законодавчого врегулювання забезпечення населення своєчасною та якісною медичною допомогою. З цією метою Президентом України поставлене завдання Кабінету Міністрів України розробити та затвердити Стратегічний план розвитку системи охорони здоров’я населення України на період до 2030 року з визначенням чітких механізмів, строків і відповідальних за виконання забезпечення рівного доступу громадян України до своєчасної, безпечної та якісної екстреної, первинної, вторинної (спеціалізованої), третинної (високоспеціалізованої), паліативної медичної допомоги та реабілітації у сфері охорони здоров’я.
Висновки. Виконання завдань, визначених Стратегічним оборонним бюлетенем України та Стратегією розвитку Медичних Сил Збройних Сил України до 2035 року передбачає поетапне нарощування спроможностей Медичних сил ЗС України для виконання завдань з медичного забезпечення ЗС України як у мирний час так і в особливий період, що корелює з перспективами розвитку системи охорони здоров’я в Україні та Стратегією людського розвитку України, рішенням Ради національної безпеки і оборони України «Про стан національної системи охорони здоров’я та невідкладні заходи щодо забезпечення громадян України медичною допомогою».
Coordination aspects of pharmacovigilance system adjustment in terms of the global COVID-19 pandemic
Authors: Ostaschenko Т. М. , Kozak N. D. , Kozak D. О. 
Published: January 2022

The purpose is to overview the crucial pharmacovigilance system adjustment measures concerning COVID-19 widespread pandemic and enlightens main current aspects of pharmacovigilance system revamp.
Materials and methods. There were used common science theoretical methods (system analysis, generalization and systems approach); bibliographic method (elaboration of scientific related literature on topic).
Results. Revamping pharmacovigilance system requires being improved in regulatory capacities, the use of appropriate public-health-driven science-based and user-friendly technologies, including digital technologies, and innovations to expand access to quality medical and relevant information. These proposals can promote health by putting pharmacovigilance at the center of efforts to achieve a sustainable healthcare system that uses universal health coverage and the health-related Sustainable Development Goals.
Conclusion. Vaccine safety is very important for the success of any vaccination program. A robust vigilance system will help detect, report and prevent any adverse reactions associated with vaccination. Effective pharmacovigilance of the COVID-19 vaccine, when ready for use, will prevent any adverse events associated with the vaccine and dispel any unreasonable concerns among vaccine users.
Історичні аспекти формування та розвитку системи медичного забезпечення Збройних Сил України
Authors: Ostashchenko Т. М. , Zhakhovskyi V. O. , Livinskyi V. G. , Shvets A. V. 
Published: January 2022

Мета роботи. Дослідження створення і становлення медичної служби Збройних Сил (ЗС) України та етапів формування і розвитку системи медичного забезпечення ЗС України.
Матеріали та методи. Використано законодавчі та нормативно-правові акти, доктринальні і керівні документи, монографії та інформаційно-довідкові матеріали щодо формування і розвитку військової охорони здоров’я та медичного забезпечення ЗС України. Методи дослідження: історичний, бібліографічний, аналітичний, системного підходу, узагальнення.
Результати. Наведено основні етапи формування та розвитку ЗС України відповідно до загальнодержавних програмних документів. Висвітлено створення і становлення медичної служби ЗС України та етапи формування і розвитку системи медичного забезпечення ЗС України у контексті будівництва та розвитку ЗС України. Розкрито та проаналізовано зміст основних заходів кожного етапу реформування і розвитку системи медичного забезпечення ЗС України, показано досягнення та акцентовано увагу на проблемах і недоліках, що мали місце під час їх проведення.
Висновки. Формування та розвиток ЗС України здійснювалися згідно законодавчих і нормативно-правових актів України. Розвиток системи медичного забезпечення ЗС України відбувався відповідно до етапів будівництва та розвитку ЗС України. Подальший розвиток системи медичного забезпечення ЗС України та нарощування спроможностей Медичних сил здійснюватиметься відповідно до нового Стратегічного оборонного бюлетеня України, що затверджений Указом Президента України від 17 вересня 2021 року № 473, та інших програмних документів щодо розвитку сил оборони.
Neoliberalismo “à brasileira”: “quem tem tudo menos cor, onde cor importa demais”
Authors: Rodrigues Silva Caroline , Rodrigues Silva Louise , Rodrigues Silva Filipe 
Published: January 2022

Esse ensaio teórico buscou refletir sobre o neoliberalismo contemporâneo. A partir da história do Brasil, intersecionada por opressões, as quais foram, sistematicamente, engendradas e convergiram em estruturas racistas, capitalistas e heterocispatriarcais. Iniciamos com a reflexão de que, mesmo o capitalismo, seguindo uma lógica, é diferenciado pelo processo histórico nos modos de produção e na acumulação primitiva situados no espaço e no tempo. O fio condutor historiográfico permitiu uma viagem resgate ao passado, não tão distante, até o contemporâneo. Foi negritado o modelo neoliberal e a eminente política da morte para a sociedade não considerada produtiva nos moldes neoliberalista brasileiro. Por fim, perguntas reflexivas foram expostas a fim de provocar novos pensares dos e nos estudos organizacionais, além de propostas de novas abordagens para estudos futuros. O estudo contribui para o campo dos estudos organizacionais ao reconstruir um processo histórico silenciado e ao problematizar perspectivas hegemônicas em administração, as quais são importadas de outros contextos sócio históricos de maneira acrítica e a-histórica, o que contribui para a manutenção da colonização do poder/saber.