bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatio-Temporal High-Resolution Subsoil Compaction Risk Assessment for a 5-Years Crop Rotation at Regional Scale
Authors: Kuhwald Michael , Kuhwald Katja , Duttmann Rainer 
Published: March 2022

Soil compaction results whenever applied soil stress by machinery exceed the soil strength. Both, soil strength and stress, are spatially and temporally highly variable, depending on the weather situation, the current crop type, and the machinery used. Thus, soil compaction risk is very dynamic, changes from day to day and from field to field. The objective of this study was to analyze the spatio-temporal dynamics of soil compaction risk and to identify hot-spot areas of high soil compaction risk at regional scale. Therefore, we selected a study area (∼2,000 km2) with intensive arable farming in Northern Germany, having a high share of cereals, maize and sugar beets. Sentinel-2 images were used to derive the crop types for a 5-years crop rotation (2016–2020). We calculated the soil compaction risk using an updated version of the SaSCiA-model (Spatially explicit Soil Compaction risk Assessment) for each single day of the period, with a spatial resolution of 20 m. The results showed the dynamic changes of soil compaction risk within a year and throughout the entire crop rotation. The relatively dry years 2016 and 2018–2020 reduced the soil compaction risk even at high wheel loads applied to soil during maize and sugar beet harvest. Contrary, high precipitation in 2017 increased the soil compaction risk considerably. Focusing on the complete 5-year period, 2.7% of the cropland area was identified as hot-spots of soil compaction risk, where the highest soil compaction risk class (“extremely high”) occurred every year. Additionally, 39.8% of the cropland was affected by “extremely high” soil compaction at least in one of the 5 years. Although the soil compaction risk analysis does not provide information on the actual extent of the compacted area, the identification of risk areas within a period may contribute to understand the dynamics of soil compaction risk in crop rotation at regional scale and provide advice to mitigate further soil compaction in areas classified as high risk.
Microplastics as an Emerging Environmental Pollutant in Agricultural Soils: Effects on Ecosystems and Human Health
Authors: Yu Hong , Zhang Ying , Tan Wenbing , Zhang Zheng 
Published: March 2022

Microplastics are &lt;5 mm in size, made up of diverse chemical components, and come from multiple sources. Due to extensive use and unreasonable disposal of plastics, microplastics have become a global environmental issue and have aroused widespread concern about their potential ecological risks. This review introduces the sources, distribution and migration of microplastics in agricultural soil ecosystems. The effects of microplastics on soil physicochemical properties and nutrient cycling are also discussed. Microplastics can alter a series of key soil biogeochemical processes by changing their characteristics, resulting in multiple effects on the activities and functions of soil microorganisms. The effects of microplastics on soil animals and plants, the combined effects of microplastics and coexisting pollutants (organic pollutants and heavy metals), and their potential risks to human health are also discussed. Finally, prevention and control strategies of microplastic pollution in agricultural soil ecosystems are put forward, and knowledge gaps and future research suggestions about microplastic pollution are given. This review improves the understanding of environmental behavior of microplastics in agricultural soil ecosystems, and provides a theoretical reference for a better assessment of the ecological and environmental risks of microplastics.
Pyroptosis-Related Risk Signature Exhibits Distinct Prognostic, Immune, and Therapeutic Landscapes in Hepatocellular Carcinoma
Authors: Zhao Yidi , Song Qingya , Xu Fangshi , Zhou Yang , Zuo Xiaoli , Zhang Zhengliang 
Published: March 2022

Background: Hepatocellular carcinoma (HCC) is a common abdominal cancer. The existing therapeutic approaches often fail to achieve satisfactory results. Pyroptosis, an inflammatory form of programmed cell death, provides new ideas for anticancer treatment. However, the roles of pyroptosis-related (PR) genes (PRGs) in HCC remain elusive.Methods: Differentially expressed genes (DEGs) (n = 22) were screened out using TCGA and GTEx databases. A novel PR risk signature was constructed through Lasso regression analysis. Its prognostic value was evaluated through a series of survival analyses and was tested in ICGC and GSE14520 cohorts. CIBERSORT, ssGSEA, and ESTIMATE methods were employed to determine the effects of the PR risk score on the tumor immune microenvironment (TIM). The TIDE scoring system, IMvigor210 cohort, GSE109211 dataset, and GSDC database were applied to explore the associations of the PR risk score with therapeutic effects. The biofunctions of WNK1 in hepatocellular cancer (HC) cells were confirmed through qPCR, colony formation, and Transwell assays.Results: Overall, 22 of 45 PRGs (48.9%) were abnormally expressed in HCC samples. Then, a PR risk signature consisting of eight PRGs was constructed. A high PR risk score led to an unfavorable prognosis. The PR risk score was identified as an independent prognostic factor of HCC and could increase the decision-making benefit of the traditional TNM model. In addition, we established a nomogram containing the clinical stage and PR risk score to predict the survival rates of HCC patients. The prognostic value of the PR model was successfully validated in ICGC and GSE14520 cohorts. Moreover, high PR risk conferred the decreased infiltration level of CD8+ T cells and weakened the activities of “cytolytic activity” pathways. As for therapeutic correlation, a high PR risk score seemed to imply a poor efficacy of PD-1/L1 inhibitors and sorafenib. Finally, the overexpression of WNK1 could promote the proliferation, migration, and invasion of HC cells.Conclusions: The PR risk score was closely related to the prognosis, antitumor immune process, therapeutic outcomes, and malignant progression of HCC. WNK1, the core regulator of pyroptosis, possesses pro-oncogenic abilities, showing promise as a novel treatment target.
Post-Infectious Autoimmunity in the Central (CNS) and Peripheral (PNS) Nervous Systems: An African Perspective
Authors: Ndondo Alvin Pumelele , Eley Brian , Wilmshurst Jo Madeleine , Kakooza-Mwesige Angelina , Giannoccaro Maria Pia , Willison Hugh J. , Cruz Pedro M. Rodríguez , Heckmann Jeannine M. , Bateman Kathleen , Vincent Angela 
Published: March 2022

The direct impact and sequelae of infections in children and adults result in significant morbidity and mortality especially when they involve the central (CNS) or peripheral nervous system (PNS). The historical understanding of the pathophysiology has been mostly focused on the direct impact of the various pathogens through neural tissue invasion. However, with the better understanding of neuroimmunology, there is a rapidly growing realization of the contribution of the innate and adaptive host immune responses in the pathogenesis of many CNS and PNS diseases.The balance between the protective and pathologic sequelae of immunity is fragile and can easily be tipped towards harm for the host. The matter of immune privilege and surveillance of the CNS/PNS compartments and the role of the blood-brain barrier (BBB) and blood nerve barrier (BNB) makes this even more complex. Our understanding of the pathogenesis of many post-infectious manifestations of various microbial agents remains elusive, especially in the diverse African setting. Our exploration and better understanding of the neuroimmunology of some of the infectious diseases that we encounter in the continent will go a long way into helping us to improve their management and therefore lessen the burden.Africa is diverse and uniquely poised because of the mix of the classic, well described, autoimmune disease entities and the specifically “tropical” conditions. This review explores the current understanding of some of the para- and post-infectious autoimmune manifestations of CNS and PNS diseases in the African context. We highlight the clinical presentations, diagnosis and treatment of these neurological disorders and underscore the knowledge gaps and perspectives for future research using disease models of conditions that we see in the continent, some of which are not uniquely African and, where relevant, include discussion of the proposed mechanisms underlying pathogen-induced autoimmunity. This review covers the following conditions as models and highlight those in which a relationship with COVID-19 infection has been reported: a) Acute Necrotizing Encephalopathy; b) Measles-associated encephalopathies; c) Human Immunodeficiency Virus (HIV) neuroimmune disorders, and particularly the difficulties associated with classical post-infectious autoimmune disorders such as the Guillain-Barré syndrome in the context of HIV and other infections. Finally, we describe NMDA-R encephalitis, which can be post-HSV encephalitis, summarise other antibody-mediated CNS diseases and describe myasthenia gravis as the classic antibody-mediated disease but with special features in Africa.
The Global, Regional, and National Burden and Trends of Infective Endocarditis From 1990 to 2019: Results From the Global Burden of Disease Study 2019
Authors: Chen Huilong , Zhan Yuan , Zhang Kaimin , Gao Yiping , Chen Liyuan , Zhan Juan , Chen Zirui , Zeng Zhilin 
Published: March 2022

IntroductionInfective endocarditis (IE) presents with increasing incidence and mortality in some regions and countries, as well as serious socioeconomic burden. The current study aims to compare and interpret the IE burden and temporal trends globally and in different regions from 1990 to 2019.MethodsData on the incidence, deaths and disability-adjusted life years (DALYs) caused by IE were extracted and analyzed from the Global Burden of Disease Study 2019. Estimated annual percentage changes (EAPC) were adopted to quantify the change trends of age-standardized rates (ASRs). Besides, potential contributors of serious IE burden were also evaluated including age, gender, social-demographic index (SDI), and age-standardized incident rate (ASIR) in 1990.ResultsGlobally, the number of IE cases and deaths has increased sharply during the past 30 years from 478,000 in 1990 to 1,090,530 in 2019 and from 28,750 in 1990 to 66,320 in 2019, and both presented an upward temporal trend annually (EAPC:1.2 for incidence and 0.71 for death). However, the EAPC of age-standardized DALYs demonstrated a negative temporal trend despite increasing DALYs from 1,118,120 in 1990 to 1,723,590 in 2019. Moreover, older patients and men were more severely affected. Meanwhile, different SDI regions had different disease burdens, and correlation analyses indicated that SDI presented a positive association with ASIR (R = 0.58, P &lt; 0.0001), no association with age-standardized death rate (R = −0.06, P = 0.10), and a negative association with age-standardized DALYs (R = −0.40, P &lt; 0.0001). In addition, the incidence of IE increased in most countries during the past 30 years (190 out of 204 countries). However, the change trends of deaths and DALYs were heterogeneous across regions and countries. Finally, we discovered positive associations of the EAPC of ASRs with the SDI in 2019 among 204 countries and territories but few associations with the ASIR in 1990.ConclusionGenerally, the global burden of IE is increasing, and there is substantial heterogeneity in different genders, ages and regions, which may help policy-makers and medical staff respond to IE and formulate cost-effective interventional measures.
The Prognostic Value of Lysine Acetylation Regulators in Hepatocellular Carcinoma
Authors: Sun Liying , Zhang Jian , Wen Kai , Huang Shenglan , Li Dan , Xu Yongkang , Wu Jianbing 
Published: March 2022

Background: Hepatocellular carcinoma (HCC) is a tumor with high morbidity and mortality worldwide. lysine acetylation regulators (LARs) dynamically regulate Lysine acetylation modification which plays an important regulatory role in cancer. Therefore, we aimed to explore the potential clinical prognostic value of LARs in HCC.Methods: Differentially expressed LARs in normal liver and HCC tissues were obtained from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) datasets. To identify genes with prognostic value and establish the risk characteristics of LARs, consensus clustering was employed. We used univariate Cox regression survival analysis and LASSO Cox regression based on LARs to determine the independent prognostic signature of HCC. CIBERSORT and Gene Set Enrichment Analysis (GSEA) were used to estimate immune infiltration and functional enrichment analysis respectively. The expression of LAR was detected by Real-time quantitative polymerase chain reaction (RT-qPCR). statistical analyses were conducted using SPSS and R software.Results: In this study, the 33 LARs expression data and corresponding clinical information of HCC were obtained using TCGA and ICGC datasets. We found majority of the LARs were differentially expressed. Consensus cluster analysis was carried out based on the TCGA cohort, and three HCC subtypes (cluster 1, 2, and 3) were obtained. The LA3 subgroup had the worst clinical outcomes. Nine key LARs were identified to affect prognosis. The results showed that LARs signature has a strong independent prognostic value in HCC patients, whether in the training datasets or in the testing datasets. GSEA results showed that various tumor-related processes and pathways were abundant in the high-risk groups. RT-qPCR results showed that HAT1, HDAC1, HDAC2, HDAC4, and HDAC11 were highly expressed in HCC cells.Conclusion: Our results suggest that LARs play critical roles in HCC and are helpful for individual prognosis monitoring and clinical decision-making of HCC.
Novel Coconut Vinegar Attenuates Hepatic and Vascular Oxidative Stress in Rats Fed a High-Cholesterol Diet
Authors: Malakul Wachirawadee , Seenak Porrnthanate , Jumroon Noppadon , Arikit Siwaret , Kumphune Sarawut , Nernpermpisooth Nitirut 
Published: March 2022

BackgroundHypercholesterolemia is an independent modifiable risk factor that accelerates the development of both non-alcoholic fatty liver and atherosclerosis. Coconut water contains a variety of phytochemicals that make it appealing for producing vinegar. Coconut vinegar is rapidly gaining popularity for health benefits in Southeast Asia. The purpose of this study is to evaluate the effect of daily supplementation of coconut vinegar on hepatic and vascular oxidative stress in rats fed a high-cholesterol diet (HCD).MethodsMature coconut water was fermented with coconut sap sugar using Saccharomyces cerevisiae and Acetobacter aceti vat Europeans, respectively. Bioactive compounds and antioxidant capacity of coconut vinegar were examined in vitro. Adult male Sprague–Dawley rats were randomly divided into four groups; the control group fed a standard diet (S), a group that received HCD (SC), a group that received HCD supplemented with coconut vinegar at a dose of 1 mL/kg/day (SCV), and a group that received HCD with atorvastatin at a dose of 30 mg/kg/day (SCA). After 8 weeks, serum metabolic profiles, fatty liver, hepatic, and vascular oxidative stress were determined.ResultsIn in vitro studies, coconut vinegar was rich in phenolic compounds and organic acids. The antioxidant capacity of 30 μL of coconut vinegar was 181.55 ± 8.15 μM Trolox equivalent antioxidant capacity (TEAC). In the HCD fed rats, daily supplementation of coconut vinegar reduced weight gain, serum triglycerides, and fasting blood sugar levels without renal or liver toxicity. In the liver, coconut vinegar reduced the accumulation of both hepatic cholesterol and hepatic triglyceride, and it also reduced hepatic 4-hydroxynonenal (4-HNE) lipid peroxidation. In the aortic tissues, coconut vinegar increased nitric oxide bioavailability and reduced aortic 4-HNE lipid peroxidation.ConclusionNovel coconut vinegar is the source of antioxidants, and daily supplementation of coconut vinegar was found to attenuate dyslipidemia-induced hepatic and vascular oxidative stress by protective against cellular lipid peroxidation.
Cancer Anxiety Mediates the Association Between Satisfaction With Medical Communication and Psychological Quality of Life After Prophylactic Bilateral Salpingo-Oophorectomy
Authors: Zarbo Cristina , Brugnera Agostino , Frigerio Luigi , Celi Chiara , Compare Angelo , Dessì Valentina , Giordano Rosalba , Malandrino Chiara , Sina Federica Paola , Strepparava Maria Grazia , Tessitore Isadora Vaglio , Ventura Mariangela , Fruscio Robert 
Published: March 2022

BackgroundProphylactic Bilateral Salpingo-Oophorectomy (PBSO) reduces the risk of developing ovarian cancer. However, the psychological mechanisms that may affect post-surgery Quality of Life (QoL) among patients who underwent PBSO are still largely unknown. Thus, this study aimed at exploring the direct and indirect associations of satisfaction with medical communication and cancer anxiety on post-surgery QoL among women at high risk of developing ovarian cancer.MethodFifty-nine women (mean age: 50.64 ± 6.7 years) who underwent PBSO took part in this cross-sectional study, filling out a sociodemographic and clinical questionnaire, a battery of validated psychological measures and an ad hoc developed scale for the assessment of cancer anxiety. We first examined the correlations among all variables of interest, and then tested if cancer anxiety mediated the association between satisfaction with medical communication and post-surgery psychological QoL, controlling both for time from surgery and education.ResultsPost-surgery psychological QoL was unrelated from any sociodemographic or clinical variable. Cancer anxiety had a significant direct negative effect on psychological QoL, while satisfaction with medical communication had a significant positive direct effect on it. Finally, cancer anxiety significantly mediated the association between satisfaction with medical communication and post-surgery psychological QoL.DiscussionResults suggest that post-surgery psychological QoL of patients who underwent PBSO may be increased with interventions, delivered in a genetic counselling setting, targeting quality of medical communication and cancer anxiety.
Minimal Impact of COVID-19 Pandemic on the Mental Health and Wellbeing of People Living With Dementia: Analysis of Matched Longitudinal Data From the IDEAL Study
Authors: Sabatini Serena , Bennett Holly Q. , Martyr Anthony , Collins Rachel , Gamble Laura D. , Matthews Fiona E. , Pentecost Claire , Dawson Eleanor , Hunt Anna , Parker Sophie , Allan Louise , Burns Alistair , Litherland Rachael , Quinn Catherine , Clare Linda 
Published: March 2022

ObjectiveResearch suggests a decline in the mental health and wellbeing of people with dementia (PwD) during the COVID-19 pandemic; however few studies have compared data collected pre-pandemic and during the pandemic. Moreover, none have compared this change with what would be expected due to dementia progression. We explored whether PwD experienced changes in mental health and wellbeing by comparing pre-pandemic and pandemic data, and drew comparisons with another group of PwD questioned on two occasions prior to the pandemic.MethodsCommunity-dwelling PwD enrolled in the IDEAL programme were split into two groups matched for age group, sex, dementia diagnosis, and time since diagnosis. Although each group was assessed twice, one was assessed prior to and during the pandemic (pandemic group; n = 115) whereas the other was assessed prior to the pandemic (pre-pandemic group; n = 230). PwD completed measures of mood, sense of self, wellbeing, optimism, quality of life, and life satisfaction.ResultsCompared to the pre-pandemic group, the pandemic group were less likely to report mood problems, or be pessimistic, but more likely to become dissatisfied with their lives. There were no changes in continuity in sense of self, wellbeing, and quality of life.DiscussionResults suggest the pandemic had little effect on the mental health and wellbeing of PwD, with any changes observed likely to be consistent with expected rates of decline due to dementia. Although personal accounts attest to the challenges experienced, PwD appear to have been resilient to the impact of lockdown and social restrictions during the pandemic.
Etiology and Pathogenesis of Macular Edema in Anterior Uveitis (Review)
Authors: Храменко Н.И. 
Published: March 2022

Статья посвящена обзору современных источников литературы, где рассматриваются этиологические факторы развития отека макулярной области при увеитах, специфические механизмы его патогенеза, нарушения функционирования внешнего и внутреннего отдела гемато- ретинального барьера, роль молекулярных факторов при отеке макулы воспалительного генеза. Важным остается понимание вопроса, почему у некоторых пациентов наблюдается один эпизод отека макулы, тогда как у других развивается рецидивирующее или хроническое его течение, резистентное к иммуномодулирующей и противовоспалительной терапии. Понимание специфических механизмов развития отека макулы важно для прицельно направленного терапевтического воздействия в управлении воспалительным процессом.
The article is a review of modern literature sources, which discusses the etiological factors of the development of edema of the macular region in patients with uveitis, specific mechanisms of the its pathogenesis, impaired functioning of the external and internal divisions of the hematoretinal barrier, the role of molecular factors in develop of macular edema of the inflammatory genesis. An important issue remains the understanding, why some patients experience one episode of macular edema, while others have a relapsing or chronic course of macular edema, that is resistant to immunomodulating and anti-inflammatory therapy. Understanding the specific mechanisms for the development of macular edema is important for a targeted therapeutic effect in controlling the inflammatory response.