bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stratégies des acteurs de l’aviculture commerciale à Ziguinchor, Sénégal
Authors: Diédhiou Sécou Omar , Margetic Christine , Sy Oumar 
Published: July 2022

Cet article a eu pour objectif de décrire les stratégies d’implantation et d’organisation de l’aviculture commerciale dans la ville de Ziguinchor au Sénégal. La dynamique et le fonctionnement des circuits d’approvisionnement et de commercialisation des produits avicoles s’inscrivaient dans un contexte de croissance démographique, d’urbanisation rapide et d’émergence d’une classe moyenne. La commercialisation des produits avicoles associait plusieurs réseaux, des circuits et une multitude d’acteurs. Des entretiens ont été menés de 2018 à 2021 auprès de 35 aviculteurs et 10 vendeurs de poulets de chair, d’aliments pour volaille et d’œufs, répartis dans sept quartiers. En l’absence de listes exhaustives d’acteurs de la filière avicole et de bases de données fiables, chaque entretien a été facilité par la rencontre préalable de spécialistes du domaine ou par le bouche-à-oreille. Dans le contexte des nouveaux enjeux de l’alimentation de proximité, les résultats confirment que l’aviculture occupe une place centrale à Ziguinchor. Une nouvelle dynamique est observée depuis 2005. Elle résulte d’une nouvelle politique nationale et de stratégies d’installation – concentration, parfois délocalisation, des lieux de production et de commercialisation – encouragées par une demande croissante de la classe moyenne. Les résultats montrent également que divers acteurs animent les réseaux et les circuits d’approvisionnement et de commercialisation en produits avicoles, contribuant ainsi à l’augmentation des quantités produites et des revenus issus de la vente.
SRI LANKA OXYGEN READINESS AND STRATEGIES ADAPTED FOR COVID-19 PATIENTS’ MANAGEMENT
Authors: Liyanage Dilip Hukkaduwa , Krishanth Maddage Don Athula , Wickramaratne Peththahandi Nadhee , Alwis Adimalee Kankanamalage Sunil Bernard De , Pannapitiya Pannapitiyage Wijeyala Chandrasiri , Perera Udawatta Arachchige Anura Sampath , Yaddehige Iranga Sachinthika 
Published: July 2022

Background: Shortly after the Covid-19 oxygen crisis in India, the Sri Lanka Ministry of Health started investigating and analyzing gaps in oxygen production, supplies and demands.
Aims: This study aimed to evaluate the preparedness in Covid-19 cases management and recommend strategies to prevent oxygen crisis in healthcare facilities.
Methods: This study used information on oxygen source redundancy and delivery methods to assess whether a healthcare facility is prepared to provide the necessary oxygen demand for patients in need and to estimate the number of patients that can be treated with the currently available oxygen supplies. The predicted oxygen supplies and demands were assessed with a panel of experts using qualitative and quantitative methods. Data were collected using the Health Information Update System.
Results: Sri Lanka had 39,529 designated hospital beds including Intensive Care Unit and High Dependency Unit beds for Covid-19 patients. Even though an average number of patients were reaching 30,000, the actual oxygen demands were around 1,200 which were easily manageable with the current capacity of 80 tons per day.
Conclusions: Sri Lanka has made progress to increase access to oxygen by using novel methods to procure and increase oxygen availability, storing, and carrying capacity.
Natural Flavonoids in the Prevention and Treatment of Lung Cancer: A Pharmacological Aspect
Authors: Talukdar Anupam Das , Nath Rajat , Das Chandrima , Kityania Sibashish , Nath Deepa , Das Subrata , Choudhury Manabendra Dutta , Patra Jayanta Kumar 
Published: July 2022

Abstract:Deadly disease cancer has many types; among them, lung cancer is responsible for the highest number of cancer mortality. Existing therapies as well as drugs for treating lung cancer are not effective and are often associated with innumerable side effects and toxicities. For these reasons, researchers have been working on developing novel anti-cancer medicines from plants and other natural sources that have a high safety profile. Natural flavonoids are a polyphenolic group of phytochemicals extracted from plants and other plant-derived compounds. Natural flavonoids are gaining popularity due to their unique and priceless medicinal properties, including anticancer properties. Several researchers have already declared that flavonoids possess the ability to treat different cancers, particularly lung cancer. The bioactivity of natural flavonoids is mainly due to their structural diversity. Natural flavonoids fight against lung cancer by regulating redox homeostasis, upregulating apoptosis, pro-apoptotic factors, and survival genes, arresting cell cycle progression, autophagy, reducing cell proliferation and invasiveness, maintaining inflammation response, downregulating anti-apoptotic factors, and targeting lung cancer signaling pathways. Flavonoids can act alone or synergistically with other agents to treat lung cancer. Due to these reasons, it is possible to use natural flavonoids as pharmaceutical leads to prevent and treat lung cancer.
An Update on Recent Green Synthetic Approaches to Coumarins
Authors: Bhimani Bhargav , Patel Ashish , Shah Drashti 
Published: July 2022

Abstract:
Coumarin and its derivatives are privileged heterocyclic motifs and important building
blocks for developing the biologically active compound due to its significant role in the development
of new drugs. As a result, many methodologies have been developed to synthesize this important
class of compounds. However, some methods are associated with toxic and corrosive catalysts, longer
reaction time, poor yield, less purity, and by-products along with the desired product. In order to minimize the utilization and generation of toxic organic substances, green synthetic methods are applied
in this manner. Green chemistry methods cover a wide range of methods, including the application of
ultrasound and microwaves, ionic liquids and deep eutectic solvents, solvent-free and catalyst-free
synthesis, and mechanosynthesis. These green synthetic methods have successfully performed all typical condensation reactions for coumarin synthesis like Knoevenagel, Perkin, Kostanecki-Robinson,
Pechmann, and Reformatsky reactions. Compared to conventional methods, these methods not only
minimize the use and generation of harmful chemicals but also improve reaction efficiency in terms
of product yields, purity, energy consumption, and post-synthetic procedures. Due to the implication
of coumarin (2-oxo-2H-1-benzopyran) backbone as a biologically active ubiquitous fragment and the
recent demands of reducing toxic solvents, catalysts, and energy consumption, this review summarized various green synthetic methods for coumarin synthesis. Moreover, researchers working on this
coumarin scaffold synthesis can find handy information from this review on the green synthetic approaches to their synthesis.
In vitro Investigation of the Effect of Anti-inflammatory and Analgesic
Drugs on Measurement of Tumor Markers
Authors: Gonel Ataman , Taskiran Huseyin 
Published: July 2022

Background:
It has been shown that some drugs used as parenteral affect biochemical
measurements. Anti-inflammatory and analgesic drugs may also have the potential to affect measurement
methods.

Objective:
The aim of the study was to investigate the effects of seven different anti-inflammatory
and analgesic pharmacological agents commonly used in wards and intensive care units on thyroglobulin,
CA125, CA15-3, CA19-9, CEA, PSA and total HCG tests measured by immunoassay
technique.

Methods:
The study was performed using hormone control material (BioRad Lyphocheck Immunoassay
Plus Control) in the PETINIA immunoassay method (Siemens, Atellica, USA). 20 μL of
tenoxicam, dexamethasone, methylprednisolone, paracetamol, diclofenac sodium, dexketoprofen,
and metamizole sodium were added into 180 μL of the control solution, respectively. After vortexing
the sample, it was incubated for 20 minutes at room temperature. Thyroglobulin, CA125, CA15-
3, CA19-9, CEA, total PSA and total HCG tests were studied from the control sample. The study
was re-performed by adding 20 μL of distilled water. The measurements were repeated 3 times, and
the mean values were recorded. Percentage deviation rates from the target value were calculated.

Results:
Metamizole sodium led to negative interference in the CA 19-9, total HCG, CA 125, CEA,
total PSA and CA15-3 at a rate of -42.1%, -24.62%, -24.34%, -23.66%, -14.33%, and -13.91%,
respectively. With the administration of metamizole sodium, the only positive interference was
determined at a rate of 6.02% in thyroglobulin. Paracetamol-induced maximum deviation was calculated
at the rate of -26.41% in CA 19-9. CA 19-9 deviated -12.22% from diclofenac sodium and -
22.41% from dexketoprofen. With methylprednisolone administration, positive interference was
detected at a rate of 14.46% in thyroglobulin and negative interference at a rate of -12% in total
PSA. The highest deviation due to dexketoprofen was seen in CA 19-9 at a rate of -22.41%.

Conclusion:
This study demonstrated the potential of anti-inflammatory, analgesic, and antipyretic
agents to affect tumor marker measurements. Especially in the follow-up of cancer patients, antiinflammatory
interference may increase the likelihood of malpractice by causing erroneous clinical
evaluations.
Deep Learning-based Inverse Design of the Complete Photonic Band Gap
in Two-Dimensional Photonic Crystals
Authors: Hao Ran , Ma Bole , Yan Haotian , Jiang Huaqing , Chen Jianwei , Tang Kaida 
Published: July 2022

Background:
With the continuous development of computer science, data-driven computing
methods have shown their advantages in various fields. In the field of photonics, deep learning
(DL) can be used to inversely design the structure of optical devices.

Objective:
The two-dimensional (2D) photonic crystal (PCs) with adjustable structural parameters
and a large complete photonic band gap (CPBG) are inversely designed in terms of DL neural network
(NN) tagged to obtain a specified width of CPBG.

Methods:
The new PCs structure is designed by combining multiple factors that produce a CPBG.
Tandem networks are used to speed up the training of the NN and tackle the problem of nonuniqueness
that arises in inverse design.

Results:
After various attempts and improvements, the ideal PCs structure was obtained. It is found
that the connecting channel between the primitives in the PCs unit cell has a dominate effect on the
CPBG. The use of a tandem network enables better convergence of the network. Finally, suitable
NN can be obtained, which can realize the forward prediction of the CPBG and the inverse design
of the structure.

Conclusion:
DL can realize forward prediction and inverse design of 2D PCs targeting the width
of the CPBG, which broadens the application scope of DL in the field of PCs.
Role of Extracellular Vesicles in Stem Cell Therapy
Authors: Kaiser Michael , Rodriguez-Menocal Luis , Badiavas Evangelos V. 
Published: July 2022

Abstract:
Burn wounds are a major source of morbidity and mortality in both the military and civilian
settings. Research about the pathophysiology of thermal injury has revealed possible interventions
that can aid this process to reduce scarring and wound contracture. Bone Marrow derived Mesenchymal
Stem Cells (BM-MSCs) have been an exciting topic in research for many years. They have
been shown to facilitate wound healing and tissue regeneration, two areas that are vital in the healing
process, especially in burn wounds. More recently the discovery of Extracellular Vesicles (EVs) has
allowed us to further characterize the immunomodulatory roles and understand the cellular pathways
implicated in wound healing. The purpose of this review is to discuss the role of EVs in wound healing,
and to propose that EVs are the main mechanism that deliver cellular materials to target cells to
coordinate wound healing following tissue injury.
Molecular Identification of Free-living Amoebae Isolated from Hospital
Water Systems in Southwest Iran
Authors: Salehi Azin , Arjmand Reza , Beiromvand Molouk , Tavalla Mehdi 
Published: July 2022

Introduction:
Free-living amoebae are opportunistic amoebae that usually live freely in
various environmental conditions, including warm water and even in water supply network pipes and
reservoirs connected to water. In addition to living freely, these protozoa are able to attack the host's
body when they enter a human or animal body. Therefore, it is necessary to identify their presence in
water resources. So, this study aimed to identify free-living amoebae isolated from water reservoirs of
hospitals in southwest Iran.

Methods:
A total of 80 water samples were isolated from the hospitals of Ahvaz city, southwest Iran,
and their physical and chemical parameters were measured. The samples were then put into non-food
agar culture medium and stained using the Wright-Giemsa staining. Finally, the samples were identified
by the PCR molecular method.

Results:
The mean pH and turbidity values were 7.57 ± 0.03 and 3.31 ± 0.26 nephelometric turbidity
unit (NTU), respectively. The mean residual chlorine and electrical conductivity were 0.91 ± 0.02 and
1122.39 ± 24.31, respectively. In addition, 9 (11.25%) and 3 (3.75%) samples were contaminated with
Acanthamoeba spp. and Naegleria spp., respectively. However, no positive cases of Balamuthia spp.
infection were observed. Moreover, two samples were co-infected with Acanthamoeba spp. and
Naegleria spp.

Conclusion:
Due to the existence of free-living amoebae in water storage tanks at hospitals, it is necessary
to prevent possible contamination with these amoebae and infectious agents by using new methods
of disinfection and purification of water resources.
Ethnopharmacology and Phytochemistry of Selected Species of Boerhavia
Occurring in India: A Review
Authors: Jachak Sanjay M. , Muley Mandar Mahendra , Doshi Shrusti Mahesh , Goyal Alok 
Published: July 2022

Background:
The plant species belonging to the genus Boerhavia (Nyctaginaceae) have
been used extensively in ethnomedicine and Ayurveda in India. Rakta punarnava and Sveta punarnava
are two of the species mentioned in various Ayurvedic formulations. Other species of Boerhavia,
though not found in the Indian system of medicine, do hold importance in ethnomedicine systems
in India and other countries.

Objective:
Boerhavia, a polymorphic genus, has been treated as a single genus encompassing species
belonging to a morphologically related genus, Commicarpus. Owing to this taxonomic quandary
with regard to the merger or separation of the two genera by different workers, there are different
reports on the number of species belonging to this genus. This has further resulted in flawed reporting
of ethnomedicinal as well as ethnopharmacological studies. The present review focuses on resolving
any confusion regarding taxonomic treatment and highlighting the ethnomedicinal uses supported
by ethnopharmacological data and the phytochemistry of Boerhavia and Commicarpus species
found in India.

Conclusion:
In India, four species of Boerhavia and two species belonging to Commicarpus are
found. The literature survey revealed that except for B. diffusa, no other species of Boerhavia has
been explored in detail. This presents an opportunity to conduct research on Boerhavia species and
find new phytochemicals with promising therapeutic effects.
Nanogel Development and its Application in Transdermal Drug Delivery System
Authors: Gaikwad Sachin S. , Akalade Nisarga V. , Salunkhe Kishor S. 
Published: July 2022

Background:Nanogels are hydrophilic polymer networks that range in size from 20 to 200 nanometers. Polymer is used to make nanogels, which can be obtained from natural or manu-factured sources. Nanogels can deliver peptides, antigens, carbohydrates, oligonucleotides, proteins, and genes, among other things. These nanogels also provide inorganic materials, such as silver na-noparticles and quantum dots. Both solid and liquid nanogels have the same properties. These nanogels penetrate the stratum corneum more effectively than conventional gels. Dermatology and cosmetology have both experimented with nanoscale technology.Objective:The medication can penetrate the stratum corneum through a variety of routes. One of the ways lipids can infiltrate the skin membrane is through the transcellular route. Cream, gel, oint-ment, lotion, thin-film, and foams are among the topical preparations used. Nanogels are catego-rised into two types: those that respond to stimuli and those that cross-link. For the manufacture of nanogels, numerous polymers of synthetic, natural, or semisynthetic origin are commonly em-ployed. Nanoprecipitation, emulsion polymerization, and dispersion polymerization are all ways to make these nanogels. These nanogels are rarely released by diffusion mechanism employing the Fick’s law.Conclusions:The nano gel is a new advanced technology that allows to improve drug molecule pen-etration in the stratum corneum. If poorly soluble and permeable medications are administered through this nanogel technology, their solubility and permeability will be improved.
Third Ventricular Colloid Cyst - An Organic Cause of Mania: A
Case Report
Authors: Penubarthi Sravanthi , Sureshkumar Kailash , C Sivabackiya , Pindicura Sundarachalam , Kailash Shabeeba Z 
Published: July 2022

Background:
Psychiatric manifestations due to space-occupying lesions, although not uncommon, are generally misdiagnosed, leading to an unfavorable outcomes. Colloid cyst is a slow-growing, benign tumor in the anterior part of the third ventricle, which frequently presents with neurological complaints like headache and gait disturbances. However, a patient with colloid cyst may also present to the OPD with a spectrum of psychiatric symptoms.

Case Report:
We here report a middle-aged man who was brought to the OPD with symptoms of pervasive irritability and disinhibited behavior for three months, along with complaints of increased activity, reduced sleep and appetite, suspicious about wife, family members and neighbors. Patient had frequent episodes of headache in the past 3 months associated with nausea, restlessness for which neuroimaging was advised, which showed a hyper-dense lesion in the third ventricle. Patient was referred to neurosurgery and was operated for the same. Post-operatively, family members reported improvement in his behavior.

Conclusion:
A detailed systemic evaluation for any neurological causes of organic causes or atypical picture of psychiatric conditions is of extreme necessity. There is a dire need for liaison of psychiatrists with neurophysicians and neurosurgeons to attain betterment in patients in both physical as well as psychological aspects, especially in psychiatric diagnosis with organic causes.
Development of a Theory-Based, Culturally Appropriate Message Library for Use in Interventions to Promote COVID-19 Vaccination Among African Americans: Formative Research
Authors: Cunningham-Erves Jennifer , Brandt Heather M , Sanderson Maureen , Clarkson Kristin , Lee Omaran , Schlundt David , Bonnet Kemberlee , Davis Jamaine 
Published: July 2022

Background
Disparities in COVID-19 incidence, hospitalization, and mortality rates among African Americans suggest the need for targeted interventions. Use of targeted, theory-driven messages in behavioral and communication interventions could empower African Americans to engage in behaviors that prevent COVID-19.

Objective
To address this need, we performed a formative study that aimed to develop and design a culturally appropriate, theory-based library of messages targeting concerns around COVID-19 vaccines that could be used in behavioral and communication interventions for African Americans.

Methods
Message development occurred between January 2021 and February 2022. Initial messages were designed by a multidisciplinary team of researchers, community leaders, and community members. Kreuter’s 5 strategies (ie, linguistic, peripheral, evidential, sociocultural, and constituent-involving strategies) were used to achieve cultural appropriateness. After forming a community-academic partnership, message development occurred in 4 phases: (1) adaptation of a message library using the literature, (2) review by 6 clinical and research experts for content validation, (3) input and review by a 6-member community advisory panel (CAP), and (4) message pretesting with African Americans via semistructured interviews in a qualitative study.

Results
Themes from the semistructured interviews among 30 African Americans were as follows: (1) community reactions to the messages, (2) community questions and information needs, (3) suggestions for additional content, and (4) suggestions to improve comprehension, relevance, and trustworthiness. Feedback from the CAP, community members, and scientific experts was used by members of the community-academic partnership to iteratively update message content to maximize cultural appropriateness. The final message library had 18 message subsets for adults and 17 message subsets for parents and caregivers of children. These subsets were placed into 3 categories: (1) vaccine development, (2) vaccine safety, and (3) vaccine effectiveness.

Conclusions
We used a 4-phase, systematic process using multiple community engagement approaches to create messages for African Americans to support interventions to improve COVID-19 vaccination rates among adults and children. The newly developed messages were deemed to be culturally appropriate according to experts and members of the African American community. Future research should evaluate the impact of these messages on COVID-19 vaccination rates among African Americans.
Posterior Segment Pathologies in Leprosy Patients with Visual Impairment: A Case Series
Authors: Adriono Gitalisa Andayani , Nadhira Andi Marsa , Kurnia King Hans , Irawati Yunia 
Published: July 2022

Leprosy is an important infectious disease, which is still prevalent in developing countries including Indonesia. This disease may affect the skin, extremities, peripheral nerves, and the eyes, causing disabilities of the patient. Leprosy is known to cause various ocular disorders, however, posterior segment abnormalities which involve the retina, choroid dan vitreous, have rarely been reported. Therefore, we present a case series of patients with posterior segment pathologies in visually impaired leprosy patients. These patients were identified during a community-based screening program on 99 leprosy patients, held in July 2019 in Alverno Hospital, Singkawang West Kalimantan. Patient comprised of inpatients and former patients who lived within the city and nearby cities who were invited for the program. All patients underwent comprehensive ophthalmology examination, performed by general ophthalmologists. Visual impairment was found in 15 patients, and their pupils were dilated, followed with posterior segment examination with indirect ophthalmoscopy and fundus photograph, using a handheld fundus camera, done by a vitreoretina specialist. Out of all patients screened, we did not find any leprosy-related posterior segment abnormalities. However, posterior segment pathologies were found in six patients, including peripapillary atrophy, myopic crescent, drusen and chorioretinal atrophy. One patient showed extensive chorioretinal atrophy with pigment clumping, which may be caused by leprosy- related chronic inflammatory process.