bluuebunny/crossref_metadata_2025_split huggingface dataset:
Um tópico de aproximação ao pensamento político grego: fins e meios na democracia ateniense do século V a. C.
Authors: Tierno Patricio 
Published: August 2022

O artigo tenta se aproximar do pensamento político grego mediante a breve introdução de algumas representações em que se faz relevante o problema da relação entre fins e meios. Nesse percurso, busca-se mostrar como essa temática se liga a diferentes modos de entender a comunidade política e a experiência democrática ateniense do século V a. C., usando como ponto de partida o papel reformador de Sólon e dando uma maior atenção às doutrinas de Protágoras e Górgias. Para finalizar, suscita-se uma reflexão de caráter formal em torno das implicações atuais que a discussão antiga sobre os fins da política possibilita.
The OSPAR NEAFC Collective Arrangement and Ocean Governance: Regional Seas Organisations as the Setters of Conservation Standards in ABNJ?
Authors: Hey Ellen 
Published: August 2022

Abstract
The Collective Arrangement, subscribed to by OSPAR and NEAFC and presented as a model by these organisations, suggests that regional seas organisations, such as OSPAR, are to act as standard setters for the conservation of marine biodiversity in areas beyond national jurisdiction (ABNJ). The model suggests that regional seas organisations and other organisations, such as NEAFC, the IMO and the ISA, then are to regulate human activities for which they are competent within these conservation standards. This article explores whether the Collective Arrangement might indeed function as a model for ocean governance in ABNJ and merits encouragement in a future BBNJ agreement. It concludes that the Collective Arrangement, as a model, raises both opportunities and challenges but that it might not be transplantable to other areas beyond national jurisdiction, given that the elements that characterise cooperation in the North-East Atlantic are not present in most other areas in ABNJ.
Why Humans Refrain from Lying: A Critical Edition of al-Ḥasan al-Raṣṣāṣ’s al-ʿAshr al-fawāʾid al-lāzima ʿan ṣīghat dalīl wāḥid
Authors: Ansari Hassan , Khalkhali Ehsan Mousavi , Thiele Jan 
Published: August 2022

Abstract
This article offers a critical edition of al-Ḥasan al-Raṣṣāṣ’s al-ʿAshr al-fawāʾid al-lāzima ʿan ṣīghat dalīl wāḥid. In this text, al-Raṣṣāṣ establishes ten premisses to prove that humans will always say the truth if lying yields no greater benefit for them. We suggest that al-ʿAshr al-fawāʾid was written in reaction to a section of Mānkdīm Shashdīw’s Taʿlīq Sharḥ al-uṣūl al-khamsa: Mānkdīm considers this proposition self-evident, whereas al-Raṣṣāṣ insists on the necessity of proving it rationally.
Strong Red Noise Ocean Forcing on Atlantic Multidecadal Variability Assessed from Surface Heat Flux: Theory and Application
Authors: Liu Zhengyu , Gu Peng , Delworth Thomas L. 
Published: August 2022

Abstract
The role of ocean forcing on Atlantic multidecadal variability (AMV) is assessed from the (downward) heat flux–SST relation in the framework of a new stochastic climate theory forced by red noise ocean forcing. Previous studies suggested that atmospheric forcing drives SST variability from monthly to interannual time scales, with a positive heat flux–SST correlation, while heat flux induced by ocean processes can drive SST variability at decadal and longer time scales, with a negative heat flux–SST correlation. Here, first, we develop a theory to show how the sign of heat flux–SST correlation is affected by atmospheric and oceanic forcing with time scale. In particular, a red noise ocean forcing is necessary for the sign reversal of heat flux–SST correlation. Furthermore, this sign reversal can be detected equivalently in three approaches: the low-pass correlation at lag zero, the unfiltered correlation at long (heat flux) lead, and the real part of the heat flux–SST coherence. Second, we develop a new scheme in combination with the theory to assess the magnitude and time scale of the red noise ocean forcing for AMV in the GFDL SPEAR model (Seamless System for Prediction and Earth System Research) and observations. In both the model and observations, the ocean forcing on AMV is in general comparable with the atmospheric forcing, with a 90% probability greater than the atmospheric forcing in observations. In contrast to the white noise atmospheric forcing, the ocean forcing has a persistence time comparable or longer than a year, much longer than the SST persistence of ∼3 months. This slow ocean forcing is associated implicitly with slow subsurface ocean dynamics.

Significance Statement
A new theoretical framework is developed to estimate the ocean forcing on Atlantic multidecadal variability form heat flux–SST relations in climate models and observation. Our estimation shows the ocean forcing is comparable with the atmospheric forcing and, in particular, has a slow time scale of years.
Evaluating GFS and ECMWF Ensemble Forecasts of Integrated Water Vapor Transport along the U.S. West Coast
Authors: Stewart Briana E. , Cordeira Jason M. , Ralph F. Martin 
Published: August 2022

Abstract
Atmospheric rivers (ARs) are long and narrow regions in the atmosphere of enhanced integrated water vapor transport (IVT) and can produce extreme precipitation and high societal impacts. Reliable and skillful forecasts of landfalling ARs in the western United States are critical to hazard preparation and aid in decision support activities, such as Forecast-Informed Reservoir Operations (FIRO). The purpose of this study is to compare the cool-season water year skill of the NCEP Global Ensemble Forecast System (GEFS) and ECMWF Ensemble Prediction System (EPS) forecasts of IVT along the U.S. West Coast for 2017–20. The skill is analyzed using probability-over-threshold forecasts of IVT magnitudes ≥ 250 kg m−1 s−1 (P250) using contingency table skill metrics in coastal Northern California and along the west coast of North America. Analysis of P250 with lead time (dProg/dt) found that the EPS provided ∼1 day of additional lead time for situational awareness over the GEFS at lead times of 6–10 days. Forecast skill analysis highlights that the EPS leads over the GEFS with success ratios 0.10–0.15 higher at lead times > 6 days for P250 thresholds of ≥25% and ≥50%, while event-based skill analysis using the probability of detection (POD) found that both models were largely similar with minor latitudinal variations favoring higher POD for each model in different locations along the coast. The relative skill of the EPS over the GEFS is largely attributed to overforecasting by the GEFS at longer lead times and an increase in the false alarm ratio.

Significance Statement
The purpose of this study is to evaluate the efficacy of the NCEP Global Ensemble Forecast System (GEFS) and the ECMWF Ensemble Prediction System (EPS) in forecasting enhanced water vapor transport along the U.S. West Coast commonly associated with landfalling atmospheric rivers and heavy precipitation. The ensemble models allow us to calculate the probability that enhanced water vapor transport will occur, thereby providing situational awareness for decision-making, such as in hazard mitigation and water resource management. The results of this study indicate that the EPS model is on average more skillful than the GEFS model at lead times of ∼6–10 days with a higher success ratio and lower false alarm ratio.
Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline
Authors: Jin Tingting , Lu Jiangting , Lv Qingbo , Gong Yingchao , Feng Zhaojin , Ying Hangying , Wang Meihui , Fu Guosheng , Jiang Dongmei 
Published: August 2022

Abstract
Background
The proliferation ability and autophagy level of pulmonary artery endothelial cells (PAECs) play an important role in promoting the development of pulmonary artery hypertension (PAH), and there is still no effective treatment for PAH. Farnesyl diphosphate synthase (FDPS) is a key enzyme in the mevalonate pathway. The intermediate metabolites of this pathway are closely related to the activity of autophagy-associated small G proteins, including Ras-related C3 botulinum toxin substrate 1 (Rac1). Studies have shown that the mevalonate pathway affects the activation levels of different small G proteins, autophagy signaling pathways, vascular endothelial function, and so on. However, the exact relationship between them is still unclear in PAH.

Method
In vitro, western blotting and mRFP-GFP-LC3 puncta formation assays were used to observe the expression of FDPS and the level of autophagy in PAECs treated with monocrotaline pyrrole (MCTP). In addition, cell proliferation and migration assays were used to assess the effect of FDPS on endothelial function, and Rac1 activity assays were used to evaluate the effect of Rac1 activation on PAEC autophagy via the PI3K/AKT/mTOR signaling pathway. In vivo, the right heart catheterization method, hematoxylin and eosin (H&E) staining and western blotting were used to determine the effect of FDPS on PAEC autophagy and monocrotaline (MCT)-induced PAH.

Results
We show that the expression of FDPS is increased in the PAH module in vitro and in vivo, concomitant with the induction of autophagy and the activation of Rac1. Our data demonstrate that inhibition of FDPS ameliorates endothelial function and decreases MCT-induced autophagy levels. Mechanistically, we found that FDPS promotes autophagy, Rac1 activity and endothelial disfunction through the PI3K/AKT/mTOR signaling pathway.

Conclusion
Our study suggests that FDPS contributes to active small G protein-induced autophagy during MCT-induced PAH, which may serve as a potential therapeutic target against PAH.
Precision and Flexible Bending Control Strategy Based on Analytical Models and Data Models
Authors: Duan Yongchuan , Tian Le , Zhang Fangfang , Liu Yu , Qiao Haidi , Yang Liu , Guan Yingping 
Published: August 2022

AbstractForming of various customized bending parts, small batches, as well as numerous types of materials is a new challenges for Industry 4.0, the current control strategies can not meet the precision and flexibility requirement, expected control strategy of bending processes need to not only resist unknown interferences of process condition and models, but also produce various new parts automatically and efficiently. In this paper, a precision and flexible bending control strategy based on analytical models and data models is proposed to build adaptive bending systems. New analytical prediction models for loading and unloading are established and suitable for various materials, a sequential identification strategy is proposed to search nominal properties using the four sub-optimization models. A data-based feedback model is established to prevent over-bending and eliminate online deviation. Above models are merged into a precision and flexible control strategy. The system firstly uses sub-optimization models to search the nominal point which is near to target point, secondly the system further uses feedback model to eliminate residual error between the nominal point and target point. Compared with four kinds sheet metals, the allowable ranges for variables are determined for a good convergence. The target bending angles were set to 20°, 40°, and 60°. Forty parts were tracked for each kind material, the adaptive bending system converged after one iteration, and exhibited better performances.
Synthesis of highly deuterated coniferyl alcohol for silencing of NMR signals in the resulting dehydrogenative polymer
Authors: Shigetomi Kengo , Tokizawa Mana , Uraki Yasumitsu 
Published: August 2022

AbstractTo establish a facile methodology for the elucidation of the lignin chain-growth mechanism, the preparation of monolignol that does not show NMR signals in the dehydrogenative polymer (DHP) was attempted. As a monolignol of which aliphatic moieties were deuterated, coniferyl alcohol-d7 was successfully synthesized from protocatechualdehyde and malonic acid via the modified Knoevenagel–Doebner reaction and the Luche reduction. The process achieved high to excellent deuteration efficiencies at the aimed positions (i.e., methoxy: > 99%D, α: > 99%D, β: 92%D, and γ: 98%D). DHP was prepared solely from coniferyl alcohol-d7, and its NMR spectra were compared with those from coniferyl alcohol. The results indicated that: (1) the deuterium atoms at methoxy group, α- and β-positions were highly retained even in the DHP, and their signals were effectively suppressed; (2) a part of the deuterium at γ-position was replaced with H through the reaction; (3) meanwhile, the formation of γ-CH2 was negligible. This study demonstrated that coniferyl alcohol-d7 could “silence” the majority of the signals even when converted to DHP. Highly deuterated monolignols can be a unique molecular tool that can differentiate the signals of interest from those derived from monolignols.
Post-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from migraine: a case–control study
Authors: Magdy Rehab , Elmazny Alaa , Soliman Shaimaa H. , Elsebaie Eman H. , Ali Sara H. , Abdel Fattah Ali M. , Hassan Mahmoud , Yassien Ahmed , Mahfouz Noha A. , Elsayed Radwa M. , Fathy Wael , Abdel-Hamid Hoda M. , Mohamed Jehan , Hussein Mona 
Published: August 2022

Abstract
Background
The burden of post-coronavirus disease (COVID)-19 symptoms has been increasing and is of great concern in patients with pre-existing chronic medical conditions.This study aimed to delineate the post-COVID-19 neuropsychiatric symptoms among migraine patients compared to the non-migraine control group.

Methods
Two groups, each of 204 COVID-19 survivors, were enrolled in the study after 3 months of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, one group fulfilling the episodic migraine criteria and the other serving as a matching control group. Subjects were evaluated through an in-person interview for post-COVID-19 neuropsychiatric symptoms, including detailed headache patterns and severity, using the visual analogue scale.

Results
The Frequency of headache during the acute phase of COVID-19 was more frequent in migraine patients (OR = 1.60, 95%CI = 1.04–2.45, P-value = 0.031). The reported significant post-COVID-19 neuropsychiatric symptoms in migraine patients compared to controls were fatigue (OR = 1.662, 95%CI = 1.064–2.596, P-value = 0.025), anosmia/hyposmia (OR = 2.06, 95%CI = 1.164- 3.645, P-value = 0.012), cacosmia (OR = 2.663, 95%CI = 1.145–6.195, P-value = 0.019), depression (OR = 2.259, 95%CI = 1.284- 3.975, P-value = 0.004), anxiety (OR = 3.267, 95%CI = 1.747- 6.108, P-value ≤ 0.001), insomnia (OR = 2.203, 95%CI = 1.298- 3.739, P-value = 0.003), and headache (OR = 3.148, 95%CI = 1.616–6.136, P-value =  ≤ 0.001).While there was no statistically significant difference between migraine patients and controls regarding the post-COVID-19 functional status score (P-value = 0.102). The pattern of post-COVID-19 headache was reported as chronic headache transformation in 17.6% of the migraine group, with the median intensity rate being 5.5 and IQR (3–7). In the control group, 14% experienced chronic headache attributed to systemic viral infection with a median intensity rate of 2 and IQR (2–5), while 12% experienced a new daily persistent headache with a median intensity of 5 and IQR (1–6).

Conclusion
The study highlighted the importance of follow-up migraine patients upon recovery from COVID-19 infection, being more vulnerable to post-COVID-19 symptoms.
Pnpla5-knockout rats exhibit reduced expression levels of proteins involved in steroid metabolism and wound healing compared to wild-type rats
Authors: Liu Zhi-Guo , Hu Yan-Qing , Li Kui , Mu Yu-Lian , Wu Tian-Wen 
Published: August 2022

Abstract
Background
Patatin-like phospholipase domain containing 5 (PNPLA5) is a newly-discovered lipase. Although the PNPLA family plays critical roles in diverse biological processes, the biological functions of PNPLA5 mostly unknown. We previously found that the deletion of Pnpla5 in rats causes a variety of phenotypic abnormalities. In this study, we further explored the effects of Pnpla5 knockout (KO) on male rats.

Results
The body weight and testicular or epididymal tissue weight of three to six 3-month-old Pnpla5 KO or wild-type (WT) male Sprague–Dawley rats were measured. The protein expression levels were also measured via western blotting and iTRAQ (isobaric tags for relative and absolute quantitation) analyses. No significant difference between Pnpla5 KO and WT rats, regarding body weight, testicular or epididymal tissue weight, or hormone levels, were found. However, the relative testicular tissue weight of the KO (Pnpla5−/−) rats was higher (P < 0.05) than that of WT rats. Significant increases in apoptotic cells numbers (P < 0.001) and BAX and Caspase-9 expression levels were observed in the testicular tissue of Pnpla5−/− rats. Moreover, iTRAQ analysis revealed that the levels of proteins involved in steroid metabolism and wound healing were significantly decreased in Pnpla5−/− rats.

Conclusion
This study revealed that Pnpla5 knockout induced apoptosis in rat testes. We also ascertained that Pnpla5 plays an important role in lipid metabolism, wound healing, and affects reproductive organs negatively, providing new target genes and pathways that can be analyzed to unravel the biological function of Pnpla5.
The CHAMP-study: the CHemopreventive effect of lithium in familial AdenoMatous Polyposis; study protocol of a phase II trial
Authors: Linssen Jasmijn D. G. , van Neerven Sanne M. , Aelvoet Arthur S. , Elbers Clara C. , Vermeulen Louis , Dekker Evelien 
Published: August 2022

Abstract
Background
Familial adenomatous polyposis (FAP) is a rare autosomal dominant disease characterized by germline mutations in the Adenomatous Polyposis Coli (APC) gene, resulting in the development of numerous colorectal adenomas. As these patients have a high risk of developing colorectal cancer (CRC), guidelines suggest prophylactic colectomy during early adulthood, however, adenoma development is still observed in the remaining intestinal tract. Therefore, FAP patients would benefit from chemoprevention strategies reducing the development of adenomas. Recent work in mice reveals a chemopreventive effect of lithium on the development of adenomas by inhibiting the expansion of Apc mutated intestinal stem cells (ISCs) within the crypts of normal intestinal mucosa. Here, we aim to investigate the effect of lithium on the spread of APC mutant cells within the human intestinal epithelium.

Methods
This prospective phase II single arm trial has a duration of 18 months. FAP patients (18–35 years) with a genetically confirmed APC mutation who did not undergo colectomy will be treated with lithium carbonate orally achieving a serum level of 0.2–0.4 mmol/l between month 6 and 12. Colonoscopy with biopsies of normal intestinal mucosa will be performed at baseline and every six months. The primary endpoint is the effect of lithium on the spread of APC mutant cells within intestinal crypts over time by using APC specific marker NOTUM in situ hybridization. Secondary endpoints include change in adenoma burden, patient reported side effects and safety-outcomes. Total sample size is 12 patients and recruitment will take place in the Amsterdam UMC, location AMC in the Netherlands.

Discussion
The outcome of this study will function as a proof-of-concept for the development of novel chemoprevention approaches that interfere with the competition between normal and mutant ISCs.
Trial registration: ClinicalTrials.gov (https://clinicaltrials.gov/): NCT05402891 (June 1, 2022) and the EU Clinical Trials Register: EuraCT 2022-000240-30 (January 1, 2022).
Acceptability and feasibility of a screening protocol for antenatal depression (SPADe) in Blantyre District, Malawi
Authors: Chorwe-Sungani Genesis , Mwagomba Modesta , Chirwa Ellen , Jere Diana , Chipps Jennifer 
Published: August 2022

Abstract
Background
Depression is one of the most common perinatal mental health problems that affect pregnant women. Antenatal depression can adversely affect the well-being of the pregnant woman and her foetus. Depression is rarely detected by midwives due to the unavailability of relevant screening instruments in Malawi. A Screening Protocol for Antenatal Depression (SPADe) was developed and recommended for possible use to screen for depression in antenatal clinics in the country. The acceptability and feasibility of using the SPADe protocol to screen for depression has not been established. The aim of this study was to assess the acceptability and feasibility of screening for depression by midwives using SPADe in antenatal clinics in Blantyre district.

Methods
This study used a quantitative survey design to collect data among 60 midwives in three antenatal clinics in primary care settings. All inclusive sampling of all 60 midwives were used. The Structured Assessment of FEasibility and Ottawa Acceptability of Decision Rules Instruments were used to collect the data. Descriptive statistics and Chi square tests were used to analyse the data.

Results
This study found that it was feasible to implement SPADe and the following enablers for screening depression had the highest ratings: the SPADe is applicable to pregnant women (M = 3.9, sd = 0.4); the intended goal of the SPADe matches the prioritised goals of Malawi Ministry of Health (M = 3.9, sd = 0.5); and the SPADe is likely to be effective (M = 3.8, sd = 0.6). On the other hand, barriers for implementing the SPADe were: the need for specific training to deliver the SPADe (M = 3.7, sd = 0.7); ongoing support and supervision (M = 3.5, sd = 0.8); and additional resources (M = 3.0, sd = 0.9). This study also found that the implementation of the SPADe was acceptable to respondents. The overall mean score for respondents on acceptability of screening antenatal depression using SPADe was found to be high (M = 4.6, sd = 0.6). However the differences in the respondents’ mean scores on acceptability of screening for depression in antenatal clinics using SPADe in relation to their demographic characteristics were not significant (p > .05).

Conclusion
This study suggests that midwives feel that it is feasible and acceptable for them to implement the SPADe in antenatal clinics with ongoing training, support and clinical supervision.