bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of novel risk prediction models of breast cancer based on stanniocalcin‐1 level
Authors: Huang Sheng , Chen Yuyuan , Wu Jiong , Chi Yayun 
Published: November 2022

AbstractPurposeThe function of stanniocalcin‐1 (STC‐1) in the oncogenesis and progression of tumors has been extensively studied. The purpose of this study was to investigate the relationship between secreted STC‐1 and prognosis in patients with breast cancer (BC) and to determine whether STC‐1 could be a key prognostic factor in BC.MethodsThe STC‐1 level was measured by ELISA and clinical data from 1210 female patients with BC were used to develop and validate nomograms. We then verified the models through the plotting of ROC curves and calibration curves, calculating the C‐index, and performing decision curve analyses (DCA).ResultsThe level of STC‐1 in the peripheral plasma was significantly correlated with the T stage, N stage, clinical stage, grade, hormone receptors, HER‐2 status, and tumor subtype. Cox regression analyses revealed that estrogen receptor(ER) status, N stage, and STC‐1 level were risk factors for overall survival (OS), whereas T stage, N stage, and STC‐1 level were independent prognostic factors for distant disease‐free survival (DDFS) and disease‐free survival (DFS). Both the ROC curve and the C‐index confirmed the high resolution of these models, while the DCA identified the feasibility of their practical application. In addition, the calibration curves indicated good consistency between the predicted and actual survival rates.ConclusionNomograms were created based on STC‐1 levels for 3‐, 5‐, and 7‐year OS, DDFS, and DFS of patients with BC respectively. As a key prognostic factor for BC, peripheral blood STC‐1 level can be used clinically as a liquid biopsy indicator.
Cutaneous and rheumatological manifestations of reactive arthritis: A case report
Authors: Slouma Maroua , Ben Dhia Siwar , Dhahri Rim , Litaiem Noureddine , Metoui Leila , Gharsallah Imen , Louzir Bassem 
Published: November 2022

AbstractReactive arthritis is a rare form of spondyloarthropathies occurring after genital or enteric infection. It is most often self‐limited but can progress to chronic spondylarthritis. We report the case of a 30‐year‐old man who presented with acute arthritis occurring 2 months after an episode of urethral discharge. Physical examination revealed polyarthritis, dactylitis, sacroiliac joint involvement, and plantar papulosquamous plaques. The human leukocyte antigen B27 was positive. Detection of Chlamydia trachomatis and Gonococcus in the first catch urine specimen was negative. Hepatitis B and C, Chlamydia trachomatis, human immunodeficiency virus, and syphilis serologic test results were negative. Pelvic magnetic resonance imaging revealed left sacroiliitis. The patient was treated with antibiotics, diclofenac, and sulfasalazine. After 6 months of follow‐up, a significant clinical improvement was obtained without remission, suggesting an evolution to chronic spondylarthritis. Diagnosis of Reactive arthritis is difficult since microbiologic examinations are commonly negative. This disease should be considered in patients with rheumatologic manifestations occurring after a urogenital or enteric infection, mainly when associated with skin manifestations and human leukocyte antigen B27.
Right lower quadrant abdominal mass: A case report
Authors: Chalise Anup , Kathayat Lok Bahadur , Poudel Prabhat , Rajbhandari Ashish Prasad , Koirala Rabin 
Published: November 2022

AbstractRight lower quadrant mass in the abdomen has many causes, but gastric perforation is rare. We discuss a 65‐year‐old lady who presented with a history of pain in her abdomen followed by swelling in her right lower abdomen. During the evaluation, a diagnosis of gastric perforation was made.
A hyperechoic mass in femoral vein
Authors: Kaku Naoko , Sugiyama Hiroki , Nakamura Kazufumi , Furutani Tomoki , Hongo Takashi , Ito Hiroshi 
Published: November 2022

AbstractHere, we present a case of fat embolism syndrome (FES) in which ultrasound sonography and computed tomography successfully visualized fat embolus in the femoral vein. A multimodality approach was particularly useful for early and specific diagnosis.
Primary cutaneous B‐Cell lymphoblastic lymphoma presenting with solitary scalp mass in a female child: A case report and review of the literature
Authors: Montazer Fatemeh , Motlagh Alireza Sanei , Dastgir Ramtin 
Published: November 2022

AbstractLymphoblastic lymphoma is a group of non‐Hodgkin lymphomas that account for approximately 2% of all lymphomas. This is a report of a case of a young girl presenting with a solitary scalp mass which was resected. Histopathological examination of the mass along with bone marrow analysis revealed primary cutaneous B‐cell lymphoblastic lymphoma. A nine‐year‐old girl presenting with an asymptomatic erythematous, non‐tender scalp mass present for 12 months was admitted. Skull and brain were intact and devoid of any pathological findings on computed tomography imaging. Systemic examination also showed no evidence of mass lesion in other parts of the body. The lesion was resected and referred for pathological analysis. Microscopic study revealed heavy diffuse dermal and subcutaneous infiltration of monomorphous medium‐sized mononuclear cells, with fine chromatin, scant cytoplasm, and variable nucleoli along with intact epidermis and presence of grenz zone. Tumor cells dissect through the collagen fibers. Extensive mitotic figures and focal infiltration of the skin adnexa are seen. IHC study revealed that TdT, CD79a, CD99, CD45, CD20, and Ki67 markers were positive. According to these findings, a definitive diagnosis of primary cutaneous lymphoblastic lymphoma of B cell type was concluded. The 1‐year follow up after necessary treatment revealed normal findings without traces of recurrence. Lymphoblastic lymphomas (LBL) are a neoplasm of immature B cells belonging to the B‐(B‐LBL) or T‐cell lineage (T‐LBL) that accounts for approximately 2% of all lymphomas. Lymphoblastic lymphoma (LBL) is similar to acute lymphoblastic leukemia (ALL) and the differentiation between these neoplasms is based upon proportion of involvement of lymphoblasts in bone marrow. It has a higher male to female predominance, higher incidence in older children and younger adults, and a relatively higher frequency of CNS and gonadal involvement. The differential diagnosis is based on immunohistochemistry study of B‐cell linage tumor markers. Cutaneous involvement is present in about one third of patients with B‐LBL but rarely in patients with ALL.
Combined type of nodular and diffuse forms of pigmented villonodular synovitis in a single knee joint of a child
Authors: Kim Dong Hwan , Noh Jung Ho 
Published: November 2022

AbstractThere are two types of pigmented villonodular synovitis (PVNS), nodular and diffuse. Two types generally do not coexist, and only one type usually occurs. This report presents a rare case of 12‐year‐old boy with combined type of PVNS in the knee joint who was treated arthroscopically.
A rare case of pycnodysostosis during pregnancy
Authors: Alshdefat Aisha , Nashwan Abdulqadir J. , Al Bibi Hayat 
Published: November 2022

AbstractWe describe a case in which a 41‐year‐old pregnant female with pycnodysostosis presented for elective cesarean section at week 37 + 5 of pregnancy. This is the first reported case of pycnodysostosis during pregnancy in Oman, to the author's best knowledge.
Leakage of Metallic Ball Seat Valves with Anisotropic Surfaces
Authors: Fischer Felix , Bady Dariush , Schmitz Katharina 
Published: November 2022

AbstractMetallic ball seat valves are an essential component of many hydraulic systems. They are used for many different purposes such as pressure relief valves or check valves. Despite their universal usage, their sealing mechanism is not yet fully understood. In previous works, a successful method for the simulation of the fluid leakage of metallic ball seat valves has been developed and confirmed experimentally. The method is based on Persson's contact mechanics theory, which is based on surface roughness power spectrum C(q). This theory takes a wide range of roughness values at different length scales into account. The previous method has been restricted to isotropic surfaces, but most surfaces of practical interest are highly anisotropic. A method for the calculation of pressure flow factors using Persson's method is presented. Based on these, a model for the leakage calculation can be developed. The simulation results are validated using an experiment.
Olive Oil Mill Wastewater Degradation: Storage Effect
Authors: Faria Benedita , Rocha Cláudio 
Published: November 2022

AbstractOlive oil mill wastewater (OMW) is one of the pollutant sub‐products produced by the olive oil industry. Nowadays, to treat the effluent and decrease its environmental impact, several studies on different methods for degradation have been developed, e.g., wastewater valorization through the steam reforming process. This work aimed to analyze how physicochemical characteristics of OMW are modified under different storage conditions. Different conditions were applied to the effluent in terms of temperature, light, and storage time. Real and synthetic OMW samples were tested during this work. The results showed that the properties of the effluent changed when it was stored at high temperatures due to degradation of organic species during storage.
Extreme High‐Speed Laser Material Application‐Coated Carbide‐Reinforced Control Plates and Conventional Lead‐Based Plates in Axial Piston Machines
Authors: Holzer Achill , Koss Stephan , Schleifenbaum Johannes Henrich , Schmitz Katharina 
Published: November 2022

AbstractHydraulic drive train technology is widely used in both mobile and stationary systems, when high forces or torques are applied. In hydraulic components, high load levels must be supported due to increasing pressure levels of the fluid. Conventionally, leaded brass is used right against steel, where the lead not only aids the manufacturing process but also provides good tribological properties, such as low friction over a wide range of speeds and pressures. Currently promising lead‐free coatings using high‐speed laser material deposition (EHLA) will be implemented in a state‐of‐the‐art axial piston pump.
Diastereo‐ and Enantioselective Reductive Mannich‐type Reaction of α,β‐Unsaturated Carboxylic Acids to Ketimines: A Direct Entry to Unprotected β2,3,3‐Amino Acids
Authors: Suzuki Hirotsugu , Kondo Sora , Yamada Koichiro , Matsuda Takanori 
Published: November 2022

AbstractStereoselective construction of unprotected β‐amino acids is a significant challenge owing to the lack of methods for the catalytic generation of highly enantioenriched carboxylic acid enolates. In this study, a novel copper‐catalyzed diastereo‐ and enantioselective reductive Mannich‐type reaction of α,β‐unsaturated carboxylic acids was developed, which provides a direct and scalable synthetic method for enantioenriched β2,3,3‐amino acids with vicinal stereogenic centers. The protocol features in situ generation of transiently protected carboxylic acids by a hydrosilane and their diastereo‐ and enantioselective reductive coupling with ketimines. The synthetic utility of this process was demonstrated by a gram‐scale reaction and the transformation of β‐amino acids.
Modifying the Stöber Process: Is the Organic Solvent Indispensable?
Authors: Wang Jinxin , Zhang Kaimin , Kavak Safiyye , Bals Sara , Meynen Vera 
Published: November 2022

AbstractThe Stöber method is one of the most important and fundamental processes for the synthesis of inorganic (nano)materials but has the drawback of using a large amount of organic solvent. Herein, ethanol was used as an example to explore if the organic solvent in a typical Stöber method can be omitted. It was found that ethanol increases the particle size of the obtained silica spheres and aids the formation of uniform silica particles rather than forming a gel. Nevertheless, the results indicated that an organic solvent in the initial synthesis mixture is not indispensable. An initially immiscible synthesis method was discovered, which can replace the organic solvent‐based Stöber method to successfully synthesize silica particles with the same size ranges as the original Stöber process without addition of organic solvents. Moreover, this process can be of further value for the extension to synthesis processes of other materials based on the Stöber process.
Structure‐Activity Relationships in Nucleic‐Acid‐Templated Vectors Based on Peptidic Dynamic Covalent Polymers
Authors: Su Dan‐Dan , Ali Lamiaa M. A. , Coste Maëva , Laroui Nabila , Bessin Yannick , Barboiu Mihail , Bettache Nadir , Ulrich Sébastien 
Published: November 2022

AbstractThe use of nucleic acids as templates, which can trigger the self‐assembly of their own vectors represent an emerging, simple and versatile, approach toward the self‐fabrication of tailored nucleic acids delivery vectors. However, the structure‐activity relationships governing this complex templated self‐assembly process that accompanies the complexation of nucleic acids remains poorly understood. Herein, the class of arginine‐rich dynamic covalent polymers (DCPs) composed of different monomers varying the number and position of arginines were studied. The combinations that lead to nucleic acid complexation, in saline buffer, using different templates, from short siRNA to long DNA, are described. Finally, a successful peptidic DCP featuring six‐arginine repeating unit that promote the safe and effective delivery of siRNA in live cancer cells was identified.
Rhodium‐Catalyzed Formylation of Unactivated Alkyl Chlorides to Aldehydes
Authors: Wang Peng , Wang Yaxin , Neumann Helfried , Beller Matthias 
Published: November 2022

AbstractThe first rhodium‐catalyzed formylation of non‐activated alkyl chlorides with syn gas (H2/CO) allows to produce aldehydes in high yields (25 examples). A catalyst optimization study revealed Rh(acac)(CO)2 in the presence of 1,3‐bisdiphenylphosphinopropane (DPPP) as the most active catalyst system for this transformation. Key for the success of the reaction is the addition of sodium iodide (NaI) to the reaction system, which leads to the formation of activated alkyl iodides as intermediates. Depending on the reaction conditions, either the linear or branched aldehydes can be preferentially obtained, which is explained by a different mechanism.
Joining Two Switches in One Nano‐Object: Photoacidity and Photoisomerization in Electrostatic Self‐Assembly
Authors: Zika Alexander , Agarwal Mohit , Schweins Ralf , Gröhn Franziska 
Published: November 2022

AbstractMulti‐switchable supramolecular nano‐objects that respond to irradiation of different wavelengths with changes in size and shape have been built from two different water‐soluble molecular switches, joined by attachment to the same polyelectrolyte. Accordingly, two wavelength‐specific reactions, namely the excited‐state proton dissociation of a photoacid and the cis–trans isomerization of an azo dye, are combined in one supramolecular nano‐object that is stable in aqueous solution. The concept has potential in the fields of sensors, molecular motors, and transport.
Mithplatins: Mithramycin SA‐Pt(II) Complex Conjugates for the Treatment of Platinum‐Resistant Ovarian Cancers
Authors: Bhosale Suhas S. , Mandal Abhisek , Hou Caixia , McCorkle J. Robert , Schweer David , Hill Kristen S. , Subramanian Vivekanandan , Kolesar Jill M. , Tsodikov Oleg V. , Rohr Jürgen 
Published: November 2022

AbstractDNA coordinating platinum (Pt) containing compounds cisplatin and carboplatin have been used for the treatment of ovarian cancer therapy for four decades. However, recurrent Pt‐resistant cancers are a major cause of mortality. To combat Pt‐resistant ovarian cancers, we designed and synthesized a conjugate of an anticancer drug mithramycin with a reactive Pt(II) bearing moiety, which we termed mithplatin. The conjugates displayed both the Mg2+‐dependent noncovalent DNA binding characteristic of mithramycin and the covalent crosslinking to DNA of the Pt. The conjugate was three times as potent as cisplatin against ovarian cancer cells. The DNA lesions caused by the conjugate led to the generation of DNA double‐strand breaks, as also observed with cisplatin. Nevertheless, the conjugate was highly active against both Pt‐sensitive and Pt‐resistant ovarian cancer cells. This study paves the way to developing mithplatins to combat Pt‐resistant ovarian cancers.
Creating sensuous experiences: Combining dichroic filters and textile weaving to create aesthetic spatial installations
Authors: Jönsson Elvira , Kooroshnia Marjan 
Published: November 2022

AbstractEven though color is frequently used in the design of textiles and spaces, research into the use of color in more innovative ways has been uncommon in relation to textile practice. This may be due to a lack of exploration of nontextile materials such as dichroic filters and their design possibilities, which not only produce colors in novel and environmentally friendly ways but also influence space by creating physical and emotional experiences. Dichroic filters are an interesting design material regarding their ability to create surfaces that change color when activated by light and when viewed from different angles and can also influence surrounding space by coloring it. This research project aims to explore the design potential of combining dichroic filters and textile weaving techniques to create textile installations that influence space and create sensuous experiences. The research project resulted in a series of textile installations wherein dichroic filters changed the expression of textile surfaces and/or influenced the installation space. The installations visually reveal a poetic relationship between the craftsmanship of textiles and light, colors, the viewer, space, and our senses. They also highlight the performative property of textiles that influence space and have the power to create sensuous experiences.
GPU implementations of deflate encoding and decoding
Authors: Takafuji Daisuke , Nakano Koji , Ito Yasuaki , Kasagi Akihiko 
Published: November 2022

SummaryDeflate coding is a very popular lossless data compression method used in zlib, gzip (GNU zip), and zip, which performs the LZSS compression algorithm with Huffman coding. Deflate encoding and decoding involve sequential operations and their parallel acceleration using a GPU is quite hard. The main purpose of this paper is to present GPU implementations for encoding and decoding of Deflate coding. For efficient GPU implementations of Deflate coding, we have used multiple small hash tables for finding matching subsequences in the dictionary by multiple threads in parallel and applied the Single Kernel Soft Synchronization (SKSS) technique to fully utilize GPU computing resources. We have also adopted Huffman coding with gap arrays to accelerate parallel Huffman decoding. We have evaluated the performance of our GPU implementations using an NVIDIA A100 GPU and compared them with parallel/sequential Deflate encoding and decoding on the Intel X86 multicore CPUs using multiple threads/a single thread. Our GPU implementation of Deflate decoding is 1.66x–8.33x faster than the multiple thread implementation and 4.13x–36.56x faster than the single thread implementation.
Solution‐Phase Chemical Synthesis of Modified RNA Dinucleotides
Authors: Senthilvelan Annamalai , Shanmugasundaram Muthian , Kore Anilkumar R. 
Published: November 2022

AbstractThis article describes a simple, reliable, efficient, and improved solution‐phase method for the gram‐scale chemical synthesis of RNA dinucleotides such as pAmpA, pAmpG, and pAmpU that utilizes phosphoramidite chemistry. The overall synthetic strategy involves three steps. The first step involves the coupling reaction between 5′‐O‐MMT protected nucleoside‐3′‐O‐phosphoramidite and a protected nucleoside containing a free 5′‐OH group in the presence of tetrazole, followed by the oxidation of phosphite triester using tert‐butyl hydroperoxide to give the corresponding protected NmpN. Next, the 5′‐O‐MMT is cleaved under 3% trichloroacetic acid in dichloromethane conditions. Finally, the 5′‐hydroxyl group is phosphorylated by the use of an activated bis(2‐cyanoethyl)‐N,N‐diisopropyl phosphoramidite using tetrazole, followed by the oxidation of trivalent to pentavalent phosphorus using tert‐butyl hydroperoxide and subsequent deprotection using ammonium hydroxide to afford the corresponding RNA dinucleotide, pNmpN, in good yields with high purity (>99.5%). © 2022 Wiley Periodicals LLC.
Accounting for long–range interaction in the Kelbg pseudopotential
Authors: Demyanov Georgy S. , Levashov Pavel R. 
Published: November 2022

AbstractAn expression for the high–temperature density matrix taking into account long–range interaction effects is obtained. The angular averaged Ewald (AAE) potential and Kelbg's solution of the Bloch equation in the first order of perturbation theory are used for this purpose. The expression generalizes the high–temperature density matrix for the Coulomb potential derived earlier by G. Kelbg. An analytical formula for the diagonal Kelbg‐AAE pseudopotential is obtained and analysed. The results can be useful in path integral Monte Carlo methods.
The impact of early‐stage COVID‐19 pandemic on the diagnosis and treatment of gastric cancer: A cross‐sectional study using a large‐scale cancer registry in Hiroshima, Japan
Authors: Kodama Masanobu , Miyamori Daisuke , Kanno Keishi , Ito Masanori 
Published: November 2022

AbstractBackgroundAfter the confirmation of coronavirus infection in Japan, a behavioral change caused people and physicians to refrain from visiting hospitals or undergoing examinations. This study aimed to assess how the trend of diagnosis in gastric cancers changed, and how it affected the therapeutic strategies and the interval from diagnosis to treatment during the COVID‐19 pandemic.MethodsWe use 15 cancer‐designated hospitals’ registries in Hiroshima, Japan. The target period was March to December 2020, and the same period in 2019 was set as the control period. The monthly mean of diagnoses and the interval from diagnosis to treatment were compared overall and separately by age, treatment procedure, diagnostic process, and clinical stage.ResultIn 2020, the monthly mean (standard deviation [SD]) of patients was 192.2 (29.9), a significant 20.1% decrease from 240.7 (20.7) in 2019 due to older age and curative treatment groups. By reason for performing endoscopy, the change rate in cancer screening, endoscopic follow‐up, and symptomatic status were ‐27.0%, ‐18.0%, and ‐17.3%, respectively. Meanwhile, the interval (days) from diagnosis to treatment (SD) was 37.8 (26.5) in 2020, significantly shorter than 46 (31.5) in 2019.ConclusionFrom 2019 to 2020, we observed a significant decrease in the diagnosis of curable early‐stage gastric cancer and treatments, although the interval from diagnosis to treatment decreased. This study suggests that cancer screening played a significant role in the decline in cancer diagnosis that occurred during the COVID‐19 pandemic. Even under COVID‐19 pandemic conditions, there should be an awareness of cancer screening and endoscopic follow‐up.