bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conditions for Reliable Divergence Estimates from Drifter Triplets
Authors: Huntley Helga S. , Berta Maristella , Esposito Giovanni , Griffa Annalisa , Mourre Baptiste , Centurioni Luca 
Published: June 2022

Abstract
Horizontal velocity gradients of a flow field and the related kinematic properties (KPs) of divergence, vorticity, and strain rate can be estimated from dense drifter deployments, e.g., the spatiotemporal average divergence (and other KPs) over a triangular area defined by three drifters and over a given time interval can be computed from the initial and final areas of said triangle. Unfortunately, this computation can be subject to large errors, especially when the triangle shape is far from equilateral. Therefore, samples with small aspect ratios are generally discarded. Here we derive the thresholds on two shape metrics that optimize the balance between retention of good and removal of bad divergence estimates. The primary tool is a high-resolution regional ocean model simulation, where a baseline for the average divergence can be established, so that actual errors are available. A value of 0.2 for the scaled aspect ratio Λ and a value of 0.86π for the largest interior angle θ are found to be equally effective thresholds, especially at scales of 5 km and below. While discarding samples with low Λ or high θ values necessarily biases the distribution of divergence estimates slightly toward positive values, this bias is small compared to (and in the opposite direction of) the Lagrangian sampling bias due to drifters preferably sampling convergence regions. Errors due to position uncertainty are suppressed by the shape-based subsampling. The subsampling also improves the identification of the areas of extreme divergence or convergence. An application to an observational dataset demonstrates that these model-derived thresholds can be effectively used on actual drifter data.

Significance Statement
Divergence in the ocean indicates how fast floating objects in the ocean spread apart, while convergence (negative divergence) captures how fast they accumulate. Measuring divergence in the ocean, however, remains challenging. One method is to estimate divergence from the trajectories of drifting buoys. This study provides guidance under what circumstances these estimates should be discarded because they are too likely to have large errors. The criteria proposed here are less stringent than some of the ad hoc criteria previously used. This will allow users to retain more of their estimates. We consider how position uncertainty affects the reliability of the divergence estimates. An observational dataset collected in the Mediterranean is used to illustrate an application of these reliability criteria.
Declining Military Surgical Cases and the Impact on Military Surgical Graduate Medical Education
Authors: Hall Andrew B. , Krzyzaniak Michael , Qureshi Iram , Cromer Robert , Tadlock Matthew D. , Patrick Danielle , Hatch Quinton , Iverson Maj Kyle , Walker Avery , Glaser Jacob 
Published: June 2022

Background Several studies have indicated a decline in the number, types, and complexity of surgical procedures within military treatment facilities (MTFs). This study aims to determine what effect, if any, these downward trends have had on the relationship between the military health system (MHS) and surgical graduate medical education. Methods Graduating chief resident final ACGME case logs from 4 of thirteen military general surgery programs were evaluated from 2015 to 2020. The proportion of total cases performed by residents at military institutions were compared on a year over year basis. Results The proportion of cases performed within the military hospitals declined 3.27% each year between 2015 and 2020 ( P < .0001) in 4 MTFs. All individual hospitals had significant declines in case volume except one (William Beaumont Army Medical Center) which increased 6.05% with each year, but also increased the number of MTF partnerships within its program ( P < .0001). Conclusions There has been a statistically significant decline over time in the proportion of cases logged by residents within the studied military treatment facilities. Investment into military hospitals to increase case numbers, case diversity, and complexity and/or acceptance of this gradual decline with greater shifting of educational workload onto civilian hospitals is required.
Complete Versus Partial Excision of an Infected Mesh Following Abdominal Wall Hernia Repair: A Systematic Review and Meta-analysis
Authors: Hajibandeh Shahin , Qayum Mohammed K. , Hajibandeh Shahab , Bodkhe Komal , Nawaz Ghulam , Faridi Nadeem , Peixoto Dinez , Kar Irfan 
Published: June 2022

Background To evaluate comparative outcomes of complete and partial excision of infected mesh following abdominal wall hernia repair. Methods A systematic search of electronic databases, including MEDLINE, EMBASE, CINAHL, and CENTRAL, and bibliographic reference lists with application of a combination of free text and controlled vocabulary search adapted to thesaurus headings, search operators and limits was conducted. Surgical site infection chronic sinus formation, recurrent hernia, and need for reoperation were the evaluated outcome measures. Results Six comparative observational studies were identified, reporting a total of 317 patients of whom 193 underwent complete mesh excision and the remaining 123 patients underwent partial mesh excision for an infected mesh following abdominal wall hernia repair. The complete mesh excision was associated with significantly lower rates of SSIs (OR: .36; 95% CI, .16-.81, P = .01), chronic sinus formation (OR: .11; 95% CI, .02-.71, P = .02), and reoperation (OR: .10; 95% CI, .03-.33, P = .0001) compared to the partial mesh excision. There was no significant difference in hernia recurrence rate (OR: 3.96.16, 95% CI .62-25.44, P = .15) between two groups. The between-study heterogeneity was moderate in all the analyses. Conclusions Complete mesh excision may be associated with lower SSI, chronic sinus formation and need for reoperation when compared to the partial mesh excision in an infected mesh event. However, the available evidence has failed to report the outcomes with respect to the main confounding factors which, together with other important outcomes such as fistula formation, should be considered by future high quality research.
Outcomes of Carotid Body Tumor Management with Active Surveillance
Authors: Lyle Daniel A. , Lopez Alexis , Osofsky Robin , Wiemann Brianne , Boyd Nathan , Olson Garth , Rana Muhammad Ali 
Published: June 2022

Objectives: To assess outcomes of carotid body tumors (CBTs) managed with active surveillance. Methods: Retrospective chart review of CBTs managed with active surveillance from 2001 to 2019. Results: A total of 115 cases were identified during chart review. Sixty-five of these patients were managed with active surveillance, and 11 patients had bilateral tumors for a total of 76 tumors. Follow-up records with symptomatic outcomes were available for 51 patients, and 47 tumors had follow-up imaging. Thirty-one (66%) actively surveilled CBTs remained stable or decreased in size while 16 (34%) increased in size. Patients undergoing active surveillance developed symptoms in 12 cases, 6 of these patients underwent surgical intervention. Nine CBTs managed with active surveillance (18%) were ultimately resected. The majority of patients who did not undergo surgical intervention never developed symptoms (36/42, 86%). Conclusions: Active surveillance may be a reasonable approach for a subset of CBTs.
A Pilot Randomized Controlled Trial of Docosahexaenoic Acid for the Treatment of Sport-Related Concussion in Adolescents
Authors: Miller Shane M. , Zynda Aaron J. , Sabatino Meagan J. , Jo Chanhee , Ellis Henry B. , Dimeff Robert J. 
Published: June 2022

The objective was to examine the use of docosahexaenoic acid (DHA) for the treatment of sport-related concussion (SRC) in adolescent athletes. We hypothesize that participants who intake 2 g of DHA daily will not experience differences in recovery compared with participants who take a placebo. This double-blind, randomized controlled pilot trial was performed in a tertiary pediatric sports medicine clinic from 2013 to 2017 in adolescents (14-18 years) presenting with diagnosed SRC within 4 days of injury. Forty participants were randomized into DHA or PLACEBO group and were instructed to take 2 capsules twice daily for 12 weeks. Participants in the DHA group were symptom-free earlier than the PLACEBO group (11.0 vs 16.0 days, P = .08) and were cleared to begin the Return to Sport progression (14.0 vs 19.5 days, P = .12) sooner. The use of 2 g/day of DHA was well-tolerated and did not significantly affect recovery times in adolescent athletes following SRC. Clinical Trial Registration: ClincalTrials.gov, NCT01903525
A retrospective examination of changes in drinking motives during the early COVID-19 pandemic
Authors: Spillane Nichea S. , Schick Melissa R. , Nalven Tessa , Crawford Michael C. , Martz Anika S. 
Published: June 2022

Objective The COVID-19 pandemic has led to substantial changes in college student alcohol use. Changes in drinking motives may explain some of these changes in drinking patterns. The purpose of the present study is to explore how drinking motives and alcohol use have changed amongst college students considering the timeframes before and after the onset of COVID-19 pandemic (i.e., March 2020) in the United States. We hypothesized that there would be significant changes in drinking motives after March 2020, which would be significantly related to changes in alcohol use. Methods Participants for the current study were undergraduate students reporting lifetime alcohol use ( n = 198, M age = 21.3, 66.7% female, 86.4% White) recruited through online advertisements in classes to complete an online survey in April 2020. Participants were asked to report on their drinking motives and alcohol use considering the timeframes before and after the onset of closures and stay-at-home orders during the COVID-19 pandemic (i.e., before and since March 2020). Results Paired samples t-tests revealed that endorsement of social ( t[171) = 12.79, p < .001, d = 1.16) and conformity motives significantly decreased ( t[170] = 4.46, p < .001, d = 0.31), while endorsement of coping motives significantly increased ( t[172] = -2.70, p = .008, d = .15) after the onset of COVID-19. Linear regression analyses, controlling for drinking motives before March 2020, revealed that changes in enhancement ( β = -.47, p < .001) and coping motives ( β = -.22, p = .04) were significantly associated with changes in alcohol use quantity. Conclusions Findings of the present study support the need for interventions to target coping and social drinking to reduce risk for alcohol use.
Lung Adenocarcinoma Metastasis to the Vocal Cord
Authors: Kim Do Hyung , Kim Nah Ihm , Jung Eun Kyung , Lee Joon Kyoo 
Published: June 2022

Metastases to the vocal cord from a distant organ are extremely rare. This case showed metastatic adenocarcinoma on the vocal cord of lung origin in a 75-year-old nonsmoking female with a history of lung adenocarcinoma surgery 2 years earlier. The vocal cord mass was surgically removed, and the biopsy confirmed metastatic adenocarcinoma of lung origin with thyroid transcription factor (TTF)-1 positivity. A further evaluation found recurrence in the lung. The patient received gefitinib. Here, we report an extremely rare case of metastatic adenocarcinoma on the vocal cord from the lung which is the first report to our knowledge.
ERBB2 mutation landscape in non-small cell lung cancer patients in Northeast China
Authors: Li Hui , Li Xiang , Lan Shaowei , Zuo Xuerong , Du Tianying , Liu Ying , Zhang Caixia , Zhu Jing , Cheng Ying 
Published: June 2022

Objective: This study aimed to explore erb-b2 receptor tyrosine kinase 2 ( ERBB2) gene mutations in patients with non-small cell lung cancers (NSCLC) in Northeast China, and to analyze ERBB2 mutation subtypes and clinicopathological characteristics related to the presence of ERBB2 mutations. Methods: In this study, 1087 tissue samples, 368 whole blood samples, and 68 pleural effusion samples from 1349 NSCLC were collected. Next-generation sequencing (NGS) was used to perform genetic testing on the samples. The proportion of patients with ERBB2 mutations and related clinicopathological characteristics were analyzed. Results: The mutation rate of ERBB2 in NSCLC was 5.58% (85/1523). Of the patients with ERBB2 mutations, 27.63% (21/76) were over 65 years old, 59.21% (45/76) were women, and 68.42% (52/76) were non-smokers. The majority of tumors were adenocarcinomas (92.1%, 70/76) and stage III and IV diseases accounted for 81.58% (62/76) of all cases. There were 14 subtypes of ERBB2 mutations; the most frequently seen were ERBB2 copy number alteration (41.76%, 38/91) and ERBB2 exon 20 in-frame insertion (36.26%, 33/91). Of the patients with ERBB2 mutations, 24 had concurrent epidermal growth factor receptor mutations, seven had mesenchymal epithelial transition factor amplifications, and three had anaplastic lymphoma kinase mutations. The agreement between tissue and paired blood samples in the presence of ERBB2 mutations was 64.3% (9/14). Conclusion: ERBB2 mutations in Northeast China NSCLC patients have a unique molecular spectrum. Our work can provide guidance for the clinical diagnosis and treatment of patients with ERBB2 mutations in Northeast China.
Patients Who Return to Sport After Primary Anterior Cruciate Ligament Reconstruction Have Significantly Higher Psychological Readiness: A Systematic Review and Meta-analysis of 3744 Patients
Authors: Xiao Michelle , van Niekerk Maike , Trivedi Nikunj N. , Hwang Calvin E. , Sherman Seth L. , Safran Marc R. , Abrams Geoffrey D. 
Published: June 2022

Background: Although objective outcomes assessing knee function are essential measurements for return to sport, psychological factors have become increasingly recognized as equally important parameters for determining an athlete’s ability to return to sport after surgery. Purpose: To systematically review the literature to determine whether patients who returned to sport after anterior cruciate ligament (ACL) reconstruction had improved psychological scores (as measured with validated questionnaires) compared with patients who did not return to sport. Study Design: Systematic review and meta-analysis; Level of evidence, 3. Methods: A systematic review was performed using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and was preregistered on PROSPERO. Four databases were searched for level 1 to 3 studies that compared at least 1 psychological outcome measured by a validated questionnaire for patients who did and did not return to sport after primary ACL reconstruction. The following data were recorded: study and patient characteristics; psychological metrics (ACL–Return to Sport Injury [ACL-RSI] scale, Knee Self-Efficacy Scale [K-SES], and Tampa Scale of Kinesiophobia [TSK/TSK-11]); International Knee Documentation Committee (IKDC) score; and clinical metrics. Study methodological quality was analyzed using the methodological index for non-randomized studies (MINORS), and the mean difference (MD) and 95% CI were calculated for each psychological outcome score using the inverse variance method. Results: We included and analyzed 16 articles (3744 patients; 38.9% female; mean age range, 17-28.7 years; mean MINORS score, 19.9 ± 1.4). Overall, 61.8% of athletes returned to sport (66.8% of male patients; 55.4% of female patients). Patients who returned scored significantly higher on the ACL-RSI scale (MD, 20.8; 95% CI, 15.9 to 25.7; P < .001), significantly higher on the K-SES (MD, 1.3; 95% CI, 0.2 to 2.3; P = .036), and significantly lower on the TSK/TSK-11 (MD, 10.1%; 95% CI, −12.1% to −8.2%; P = .004). Those returning to sport did not exceed the minimal clinically important difference for IKDC score versus those not returning to sport. Conclusion: Patients who returned to sport after primary ACL reconstruction had significantly higher psychological readiness, higher self-efficacy, and lower kinesiophobia compared with those who did not return to sport, despite having clinically similar knee function scores. Evaluation of psychological readiness, in combination with other objective measurements, is a critical component of return-to-sport evaluation in athletes after primary ACL reconstruction. Registration: CRD42021284735 (PROSPERO).
Long-term Outcomes After the Open Latarjet Procedure for the Surgical Management of Humeral Avulsion of the Glenohumeral Ligament Lesions
Authors: Domos Peter , Gokaraju Kishan , Walch Gilles 
Published: June 2022

Background: Recurrent anterior glenohumeral instability caused by a humeral avulsion of the glenohumeral ligament (HAGL) lesion has been studied, but very limited long-term evidence is available. Purpose: To retrospectively review patients with a HAGL lesion who underwent an open Latarjet procedure for recurrent anterior shoulder instability. Study Design: Case series; Level of evidence, 4. Methods: A total of 16 patients with complete clinical and radiological data were available for a review. Clinical outcomes were assessed by range of motion, apprehension testing, the visual analog scale for pain, the Walch-Duplay score, the Rowe score, the Constant-Murley score, the Subjective Shoulder Value, and return to sports. Radiographs were reviewed for osteoarthritis and complications. Results: The median age of patients at the time of surgery was 28 years (range, 18-42 years). All patients were male with no hyperlaxity. The median follow-up time was 10 years (range, 2.8-15 years). Postoperative range of motion showed recovered forward elevation (median, 175°), external rotation (median, 62°), and internal rotation (median, 9 points). Overall, 87% returned to sports, with 68% to the same level and 93% satisfied or very satisfied. Median clinical outcomes were the following: visual analog scale score, 1 (range, 0-2); Walch-Duplay score, 86 (range, 75-100); Rowe score, 95 (range, 90-100); Constant-Murley score, 77 (range, 74-79); and Subjective Shoulder Value, 88% (range, 80%-95%). There were no recurrent dislocations or subluxations. One patient described mild long-term pain, and 1 patient had persistent stiffness. Other complications included 12% with subjective apprehension, 1 patient with a wound infection, and another patient with delayed bone graft union. Additionally, 56% of cases had mild postoperative arthritis at the final follow-up. There were no reoperations. Conclusion: The open Latarjet procedure provided good outcomes with acceptable complication rates in the long term for patients with HAGL lesions. It is an effective treatment option and a safe alternative to arthroscopic or open HAGL repair.
Clinical significance of chromosomal integrity in gastric cancers
Authors: Zhang Rukui , Liu Zhaorui , Chang Xusheng , Gao Yuan , Han Huan , Liu Xiaona , Cai Hui , Fu Qiqing , Liu Lei , Yin Kai 
Published: June 2022

Background A whole-exome or targeted cancer genes panel by next-generation sequencing has been used widely in assisting individualized treatment decisions. Currently, multiple algorithms are developed to estimate DNA copy numbers based on sequencing data, which makes a comprehensive global glance at chromosomal integrity possible. We aim to classify gastric cancers based on chromosomal integrity to guide personalized therapy. Methods We investigated copy number variations (CNV) across the entire genome of 124 gastric carcinomas via exome or targeted sequencing. Chromosomal integrity was classified as chromosomal stability (CS), chromosomal instability (CIN) and intermediate state (CIN/CS) based on CNV results. Chromosomal integrity was correlated to molecular features and clinical characteristics. Results According the states of chromosomal integrity, gastric carcinomas can be stratified into two cohorts: CS and CIN. Our results showed a significant relationship between CIN status and TP53 mutation, but not RB1, phosphatase and tensin homolog (PTEN), or other reported DNA damage repair genes. The mutation frequency of the TP53 gene had great relevance. Our study initially revealed clinical significance of chromosomal integrity that CIN patients were prone to HER2-positive and mucinous adenocarcinoma, while CS patients were a diffuse subtype and poorly differentiated but had longer overall survival. Conclusions We classified gastric carcinomas into two states of chromosomal integrity with clinical implications. The dichotomy is applicable to clinical transformation. We proposed that classifying gastric cancers based on chromosomal integrity would enable us to achieve personalized therapy for patients and may be beneficial to patient stratification in future clinical trials.
Factors influencing mental health nurses in providing person-centered care
Authors: Ahn Suyoun , Yi Yeojin 
Published: June 2022

Background Mental health nurses advocate for patients through a person-centered approach because they care for people experiencing mental distress who tend to be limited to exercising their human rights and autonomy through interpersonal relationships. Therefore, it is necessary to provide high-quality person-centered care for these patients by identifying the influencing factors. Aim This study aims to identify the factors affecting mental health nurses in performing person-centered care for patients. Research design This study had a cross-sectional, descriptive-correlational survey design. Participants and method Nurses ( N = 166) working at psychiatric wards in Korea completed an online questionnaire on moral sensitivity, attitudes toward people with mental illness, and person-centered care. The t-test and stepwise multiple regression analysis were used. Ethical considerations Ethical approval for the study was obtained from the relevant ethics committee. Findings Moral sensitivity was a significant factor correlating with the provision and perception of person-centered care. Attitudes toward patients had no effect on person-centered care. The predictor variables for the provision of person-centered care (R2 = 0.247) were moral sensitivity (β = 0.33), having a professional qualification (β = 0.19), marital status (β = 0.18), and closed ward (β = −0.15). The predictor variables for the perception of person-centered (R2 = 0.150) care were closed ward (β = −0.25), moral sensitivity (β = 0.23), and marital status (β = 0.18). Discussion and conclusion Mental health nurses can strengthen person-centered care by improving moral sensitivity related to the ethical aspect of nursing and professional competence to address the complex needs of patients. Person-centered care needs to be applied more carefully in closed wards where human rights issues may arise. Through these efforts, the dignity of patients can be protected.