bluuebunny/crossref_metadata_2025_split huggingface dataset:
De la radio convencional a la móvil. Usabilidad, multimedialidad y distribución de contenidos en las radioAPPs portuguesas
Authors: Piñeiro-Otero Teresa 
Published: August 2022

La penetración alcanzada por los smartphones y la banda ancha móvil en Portugal han generado un contexto propicio para el desarrollo de la radiofonía móvil. Conscientes de esta oportunidad las emisoras portuguesas han expandido su universo online a esta plataforma de difusión, una expansión que se ha reflejado en la oferta de aplicaciones para el acceso optimizado a los contenidos y canales de la radiofonía net.
No obstante, en su salto a la plataforma móvil, estas emisoras de radio presentan importantes divergencias tanto en la complejidad estructural y usabilidad de dichas aplicaciones, como en la esencia y distribución de sus contenidos.
En este sentido el presente trabajo ha tenido por objeto efectuar un análisis exploratorio de las principales RadioAPPs portuguesas para determinar su adaptación esta plataforma de emisión. Una adaptación que se ha abordado desde la perspectiva de los contenidos, funcionalidad y accesibilidad de dichas aplicaciones.
El análisis efectuado ha permitido señalar la limitada adaptación de estas aplicaciones a los terminales móviles y determinar tendencias en el diseño y contenido de las radioAPPs atendiendo al tipo de emisora (generalista o especializada) y el sistema operativo (iOS o Android).
Palabras clave: Radio, Radiodifusión online, RadioAPP, Aplicaciones, Comunicación móvil.
Medicina tradicional (Herbolaria) en odontología
Authors: Orellana Centeno Jose Eduardo 
Published: August 2022

Durante la consulta estomatológica uno de los padecimientos más frecuentes son las odontalgias, comúnmente conocidas como “dolor dental o dolor de muelas”. Su intensidad obliga al paciente a atenderse inmediatamente. Dicha alteración, por su magnitud, disminuye la capacidad y rendimiento de muchas personas1.
La sensación de dolor dentario se origina en los receptores situados en la pulpa que contiene fibras nerviosas. El cemento y esmalte son insensibles por carecer de dichas células, gracias a las cuales se identifica el dolor dentinario que es intenso y dura pocos segundos, el cual es ocasionado por agentes externos (bebidas frías o calientes, ácidos o dulces etc.). A diferencia de éste, el dolor pulpar puede ser intermitente, desde ligero hasta insoportable y aparecer de manera espontánea sin que exista aparentemente un estímulo2.
Christian Understanding of the Human Person in the Perspective of African Cultures
Authors: Konye Michael Nnamdi 
Published: August 2022

The article attempts to present a few perspectives from African cultures on the Christian understanding of man. The central thesis argued for is that the interpenetration of the universalizing Christian culture and the particularizing cultures of indigenous peoples need not always breed tensions of values. As always, there are common entry points for harmonization which facilitates evangelization in view of those salvific fruits which `grace' always offers to `nature'.
It can thus be clear from the above that my overall aim in this article is to show how the African cultural perspectives on the being of man shapes the reception of the Christian gospel about the human person as redeemed by Christ. To be sure, the key questions to which this article responds present themselves as follows: In what light does the Christian understanding of human person appeal to the African? In other words, what is the African perspective of the being of man and how does it influence the African's understanding of the Christian gospel of the redeemed humanity? Structurally, the article consists of three sections: First I shall present several entry points to the understanding of the human person, besides the chosen two perspectives — Christian and African — which we wish to harmonize. Next, I shall highlight the key principles which inform Christian anthropology on the one hand; as well as a few cultural generalities which are descriptive of a typical African anthropology. Finally, I try to present selected `anthropological' elements which highlight comparisons and divergences between Christianity and African cultures.
A Personal Meditation on the Cultural Ecumenism of the Romanian Orthodox Immigrants in Western Europe
Authors: Tăut Mădălin Vasile 
Published: August 2022

Migration of peoples is a phenomenon whose existence is lost in the mist of history. People have always traveled from one country to another for political, economic, social, cultural, climatic or demographic reasons, and the story continues also today. The intention of this essay is not to analyze the migration of the Orthodox Romanians from a strictly historical or sociological perspective, because numerous scientific studies have already been written on this topic, but rather to understand their process of soul alienation. Therefore, after making a mention of the social and economic evolution of Western society by moving from one system of philosophical values to another, which practically marked its thinking and development, I will try to explain the versatility of the Romanian Orthodox in terms of their desire for material prosperity, by assuming the culture of the capitalist economy, with the risk of giving up even only apparently the values inherited by birth and Christian tradition.
Wcielenie jako Logos zapośredniczony. Refleksje na podstawie myśli Paula Tillicha
Authors: Walczak Marcin 
Published: August 2022

Pośrednictwo pozostaje do dziś jednym z ważnych tematów dialogu ekumenicznego. Punktem wyjścia dla refleksji nad teologicznym pośrednictwem zawsze pozostaje pośrednictwo Chrystusa. Niniejszy artykuł analizuje, jak funkcjonowało ono w myśli jednego z wielkich teologów protestanckich XX wieku, Paula Tillicha. Najpierw przedstawiona została jego koncepcja Logosu, właśnie jako pośrednika. Potem ukazana zostła Tillicha koncepcja Wcielenia, którą można przedstawić jako koncepcję kluczowego zapośredniczenia się Boga w świecie, a następnie Tillichowa ocena dogmatu chrystologicznego. Przeprowadzone analizy pozwolą spojrzeć z pewną świeżością na tak istotną ekumenicznie kwestię, jaką jest teologiczne pośrednictwo. Autentyczne pośrednictwo jest ostatecznie darem Boga, a nie produktem człowieka.
Rola kolistych RNA w stwardnieniu rozsianym
Authors: Żurawska Anna 
Published: August 2022

Stwardnienie rozsiane jest przewlekłą zapalno-demielinizacyjną chorobą ośrodkowego układu nerwowego. Jej etiologia nie jest w pełni poznana, wiadomo jednak, że mechanizmy odpowiedzialne za jej rozwój w znacznym stopniu zależą od procesów autoimmunologicznych. Uważa się, że jest to choroba wieloczynnikowa, która powstaje przy udziale czynników genetycznych, środowiskowych i epigenetycznych. Jednym ze szczególnie znaczących odkryć na polu epigenetyki w ostatnich latach była identyfikacja małych niekodujących cząsteczek RNA – mikroRNA (miRNA). Wcześniejsze badania wykazały związek niektórych miRNA z regulacją autoimmunologicznej demielinizacji u chorych na SM. Ponieważ regulacja ekspresji miRNA jest procesem bardzo dynamicznym i złożonym, coraz więcej dowodów wskazuje na znaczenie kolejnego wyższego poziomu mechanizmu regulacyjnego miRNA. Coraz więcej danych wskazuje, że może nim być aktywność nowej unikalnej grupy cząsteczek – kolistych RNA (circular RNA; circRNA). Nazywane one są „naturalnymi gąbkami dla miRNA”. Udowodniono, iż circRNA odgrywają rolę w wielu procesach fizjologicznych i patologicznych ośrodkowego układu nerwowego oraz układu immunologicznego.
The 12-Month Effects of the Trauma Collaborative Care Intervention
Authors:   Major Extremity Trauma Research Consortium (METRC)
Published: August 2022

Background:
Studies have suggested that patient-centered collaborative care in the early phases of recovery may assist providers and patients in managing the multifactorial consequences of injury and may lead to better outcomes. This cluster-controlled trial, conducted at 12 U.S. Level-I trauma centers, was designed to evaluate the impact of the Trauma Collaborative Care (TCC) program on 1-year outcomes following severe musculoskeletal injury.

Methods:
Patients with high-energy orthopaedic trauma requiring surgical fixation were prospectively enrolled. Six sites implemented the TCC intervention as well as the Trauma Survivors Network (TSN), and the other 6 sites provided the standard of care. Participants were followed for 1 year, and a composite primary outcome measure composed of the Short Musculoskeletal Function Assessment (SMFA) Dysfunction Index, Patient Health Questionnaire-9 (PHQ-9), and Posttraumatic Stress Disorder Checklist (PCL) was assessed. A 2-stage, Bayesian hierarchical statistical procedure was used to characterize treatment effects. Sensitivity analyses were conducted to account for an error in the delivery of the intervention.

Results:
There were 378 patients enrolled at 6 trauma centers implementing the TCC program, and 344 patients enrolled at 6 trauma centers providing usual care. Patient utilization of treatment components varied across the intervention sites: 29% of patients in the intervention group received all 5 key components (TSN handbook education, peer visits, recovery assessment, and calls before and after recovery assessment). Posterior estimates of the intention-to-treat effect suggested that the intervention did not have an appreciable effect: the odds of the composite outcome for the TCC group increased by 5% (95% credible interval, −40% to 63%). The estimates of the effect of receiving all 5 key intervention components were similar.

Conclusions:
Despite prior work showing early positive effects, this analysis suggests that the TCC program as delivered did not have positive effects on patient outcomes at 1 year. It is not known whether programs that improve compliance or target specific subgroups would better meet the psychosocial needs of trauma survivors.

Level of Evidence:
Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Maternal urine phthalate metabolite exposure and miscarriage risk: A nested case–control study of the Zunyi Birth Cohort
Authors: Wang Xia , He Caidie , Wu Nian , Tian Yingkuan , Wang Linglu , Liao Juan , Fang Derong , Liu Xiang , An Songlin , Chen Wei , Xiong Shimin , Liu Yijun , Xie Yan , Tian Kunming , Huang Jingyi , Yuan Hongyu , Chen Xiaoshan , Zhang Li , Li Quan , Shen Xubo , Zhou Yuanzhong 
Published: August 2022

Abstract
Phthalates (PAEs) are widespread persistent organic pollutants and endocrine disruptors. Exposure to certain phthalate metabolites can increase miscarriage risk, but the associations between PAE exposure and the risk of miscarriage in humans are unclear. In addition, an insufficient number of studies have evaluated the possible threshold or dose-dependent effects of first-trimester PAE exposure on miscarriage risk. In a nested case–control study of the Zunyi Birth Cohort, we compared 150 pregnancies ending in miscarriage and 150 pregnancies with live births as controls. The levels of mono-methyl phthalate (MMP), mono-ethyl phthalate, mono-isobutyl phthalate, MiBP mono-butyl phthalate (MBP), mono-octyl phthalate, mono-benzyl phthalate, mono(2-ethylhexyl) phthalate, mono(2-ethyl-5-oxohexyl) phthalate, and mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) in maternal urine collected in early gestation were measured. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) for miscarriage and each PAE as a continuous variable or quartile. Sensitivity analysis and multiple adjustments were performed on the results. A restrictive cubic spline was used to assess dose-dependent effects after controlling for maternal characteristics (e.g., age, educational level). This study identified monotonically increasing dose-dependent effects of MEHHP and MMP on the risk of miscarriage. The largest effect estimates were approximately 3–4-fold higher for the highest MBP (OR = 2.57; 95% CI = 1.32–5.01) or MMP quartile (OR = 3.57; 95% CI = 1.82–7.00) and 2-fold higher for the highest MEHHP quartile (OR = 2.12; 95% CI = 1.10–4.11. Our research preliminarily obtained possible thresholds, for the risk of miscarriage, and the corresponding concentrations of MBP, MEHHP, and MMP were approximately 18.07, 2.38, and 0.80 µg/g Cr, respectively. First-trimester exposure to MBP, MEHHP, and MMP exceeding certain thresholds increases the risk of miscarriage. Thus, strong caution is needed, and preventative and control strategies are required to reduce the risk of PAE exposure.
In vivo Evaluation of the Antipsoriatic Effect of Alginate Hydrogel with Lavandin Essential Oil and Its Main Components after Topical Application
Authors: Sosnowska Katarzyna , Tomczykowa Monika , Winnicka Katarzyna , Kalemba Danuta , Tomczyk Michał 
Published: August 2022

Abstract
The essential oils obtained from Lavandula species possess antibacterial, antifungal, anti-inflammatory, and antioxidant activities. In our study, lavandin oil was hydrodestillated from Lavandula × intermedia (Lamiaceae), and new alginate-based hydrogel formulations containing lavandin oil, linalool, and linalyl acetate were prepared for the first time. Using the gas chromatography (GC) and gas chromatography - mass spectrometry (GC-MS) methods fifty eight components of obtained essential oil were identified. Subsequently, the antipsoriatic activity of the created formulations was investigated by applying an imiquimod-induced mouse model. Alginate-based hydrogels were used as carriers for lavandin oil, linalool, and linalyl acetate. Pharmaceutical properties, such as viscosity and adhesiveness, which influence the contact time of the formulation to the skin, were also analysed using a viscometer and texture analyser, respectively. In addition, the histopathological examination of imiquimod-induced psoriasis-like mice ear skin stained with H&E (haematoxylin and eosin) was conducted after applying the examined formulations. Additionally, the impact of lavandin oil, linalool, and linalyl acetate on the expression of CD3 (cluster of differentiation 3), CD68 (monoclonal mouse anti-human), and Ki67 (marker of proliferation Ki-67) were studied. Histopathological studies showed that alginate-based hydrogels with lavandin oil, linalool, and linalyl acetate decreased the mice ears’ oedema and the analysed psoriasis symptoms (parakeratosis epidermal thickening, hypertrophy of the spinous layer, inflammatory infiltrates, Munro's microabscesses, Kogoj's micro-pustules, and dermal papillae oedema). The prepared formulations inhibited proliferation of the cells (Ki67 staining method) and expression of CD3 and CD68. The most potent activity against the inflammation in psoriasis was the preparation containing 5% lavandin oil. The presented results suggest that the topical application of lavandin oil may be efficient against psoriasis due to the inhibition of cell proliferation and reduction in many T-cells, macrophages, and lymphocytes in mice ear skin with inflammation induced by imiquimod.
Autoimmune polyendocrine syndrome II presenting paradoxically as Takotsubo cardiomyopathy: A case report and reappraisal of pathophysiology
Authors: Batta Akash , Gupta Amit Kumar , Singal Gautam , Mohan Bishav , Kumar Sushil , Jaiswal Bhavuk , Hatwal Juniali , Tandon Rohit , Singh Gurbhej , Goyal Abhishek , Singh Bhupinder , Mittal Naveen , Chhabra Shibba Takkar , Aslam Naved , Wander Gurpreet Singh 
Published: August 2022

Abstract
BackgroundTakotsubo cardiomyopathy (TCM) is a rare disease entity characterized by acute, non-ischemic, reversible myocardial dysfunction that mimics acute myocardial infarction. Activation and excessive outflow of sympathetic nervous system is believed to be central to the figure in the disease pathogenesis. Adrenocortical hormones potentiate the systemic actions of sympathetic nervous system and accordingly are essential for regulation of myocardial function. We present an unusual case of a middle-aged woman with primary adrenal insufficiency who presented paradoxically with TCM. Case presentation A 50-year-old woman with past history of hypothyroidism presented to emergency department with history of acute chest pain and syncope. There was no significant drug history or history of an emotional or physical stimulus prior to admission. Prominent pigmentation over the tongue and skin creases of hands were noted. On presentation she was in shock and had ventricular tachycardia which required electrical cardioversion. The subsequent electrocardiogram demonstrated diffuse T-wave inversions with prolonged QTC. There was apical hypokinesia on echocardiogram and cardiac biomarkers were elevated. There was persistent inotropic requirement. She had marked postural symptoms and a postural blood pressure drop of 50mm Hg was present. Initial laboratory parameters were significant for hyperkalemia (7.8mEq/L) and hyponatremia (128mEq/L). These findings prompted evaluation for adrenal insufficiency which was confirmed with appropriate tests. Autoimmune polyendocrine syndrome II was thus diagnosed based on the above findings. Coronary angiography revealed normal coronaries. The diagnoses of TCM was established in accordance with the International takotsubo diagnostic criteria. She was started on stress dose steroid replacement therapy and improved dramatically. At one month of follow-up, the patient is asymptomatic and there was normalization of her left ventricular function. ConclusionsIntricate relationship and interplay exist between the steroid hormones and catecholamines in the pathogenesis of TCM. Steroid hormones not only potentiate the actions of catecholamines, they also regulate and channelize catecholaminergic actions preventing their deleterious effects on the cardiac tissue. Hence, both steroid deficiency and exogenous steroid replacement may precipitate TCM. Evidence from more such cases and larger perspective studies in the future will further improve our understanding of this complex disease process and its myriad associations.
A study on microzooplankton community from the coastal waters of eastern Arabian Sea: Emphasis on the dominance of heterotrophic dinoflagellates
Authors: S Sai Elangovan , Gauns Mangesh U 
Published: August 2022

Abstract
We studied the community composition of microzooplankton (MZP) from the surface waters off Candolim, Goa. The MZP communities were examined for the year 2013, covering different seasons and four stations (Near-shore: G3 & G4, offshore: G5 & G6). A total of 30 species belonging to 24 genera were recorded, which include loricate ciliates (LC: 14 species of 13 genera), aloricate ciliates (ALC: 5 species of 3 genera), heterotrophic dinoflagellates (HDS: 11 species of 8 genera) and copepod nauplii. The MZP abundance in the coastal waters varied spatially irrespective of different seasons, with higher abundance in the offshore stations (G5 & G6, 38–127 cells L-1) and lower abundance in the near-shore stations (G3 & G4, 20–97 cells L-1). The MZP community composition showed the dominance of HDS (16–85%) in the near-shore stations during most of the seasons and inferiority during NEM (16–18%,). Moreover, all the coastal waters (near and offshore) were dominated by HDS (58–85%) during spring inter-monsoon. The dominant species of HDS were Dinophysis apicata, Dinophysis caudata, Porocentrum micans, Protoperidinium breve, Protoperidinium latistriatum, and Protoperidinium granii. The statistical analysis (Spearman's rank correlation) depicts that the MZP abundance and community composition were mainly controlled by salinity (r = 0.4–0.7). Whereas the dominance of HDS in the coastal waters could be the reason for its mixotrophic nature and diverse feeding mechanism. Thus, a strong positive correlation between the HDS and LC (r = 0.73–0.92) showed the feeding ability of HDS in their relative community.
Peptides formed during simulated digestion of human colostrum: prospection of bioactivity
Authors: Campanhon Isabele B. , Aguiar Paula Fernandes , Bezerra Flávia Fioruci , Soares Márcia R. , Torres Alexandre Guedes 
Published: August 2022

Abstract
Breast milk is known to contain bioactive peptides that are released during digestion, being a major source of bioactive peptides to the new-born, some of which act against invading pathogens. However, the formation of bioactive peptides during digestion of human colostrum remains largely uninvestigated. This study aimed to investigate the formation of peptides during simulated digestion of human colostrum from adult women, and to prospect antimicrobial peptides. For this purpose, we used high-resolution mass spectrometry to monitor the release of peptides during simulated digestion. Bioinformatics was used for the prospection of antimicrobial activity of peptides. During simulated digestion (oral, gastric, and duodenal phases), 2318 peptide sequences derived from 112 precursor proteins were identified. At the end of simulated digestion, casein-derived peptide sequences were the most frequently observed. Among precursors, some proteins were seen for the first time in this study. The resulting peptides were rich in proline, glutamine, valine, and leucine residues, providing characteristic traits of antimicrobial peptides. From bioinformatics analysis, seven peptides showed potentially high antimicrobial activity towards bacteria, viruses, and fungi, from which the latter was the most prominent predicted activity. Antimicrobial peptides released during digestion may provide a defence platform with controlled release for the new-born.
Social Identity, Health Rights and Medical Ethics: An Analysis of the Attitudes of Caregivers of Public Health sector in the Medical Care of Transgender People in Côte d’Ivoire
Authors: OUATTARA Zié Adama , BROU Kouamé Aristide , KOUADIO Lorraine Nadia , N'DRI Koffi Célestin 
Published: August 2022

Abstract
In Côte d'Ivoire, as in many other parts of the world, Lesbian, Gay, Bisexual and Transgender (LGBT) people in general, and transgender people in particular, face enormous difficulties in accessing care. They are victims of their social identity and are stigmatized and marginalized from the health care system. In most public health structures, their medical care is problematic due to the reluctance of health care providers. We are witnessing less responsible attitudes among some caregivers in public health sector. According to the literature, LGBT people are vulnerable to several diseases, including HIV/AIDS. As such, they require specific health care. This situation experienced by LGBT people constitutes a denial of the right to health and of medical ethics. Indeed, health is a universal right that advocates equal access to health care. As for medical ethics, it requires caregivers to have a humanitarian duty, probity, loyalty and respect for human life. Thus, regardless of the patient's status, social identity, the caregiver's vocation and duty is to administrate the necessary care, while respecting professional secrecy. Between law, ethics and attitudes, this socio-anthropological research conducted among caregivers and transgender people in particular, proposes to understand this paradox, this contradiction that results in Côte d’Ivoire. In other words, it analyzes the attitudes of caregivers in the medical care of transgender people in a context of universality of health, right to health and ethical principles governing the medical profession in Côte d’IvoireBouaké.