bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Combined Treatment Effect of Cilostazol and Pentoxifylline in the Treatment of Peripheral Vascular Disease
Authors: Suthar Jalpa , Shah Birju , Ranjan Ritu 
Published: September 2022

Background: (50 mg BD) and pentoxifylline (400 mg TDS) therapy in patients with PVD. Additionally, the adverse effects and economic burden of the combination was taken in to account.
Methodology: An Observational antegrade study was done among 100 patients. A Patient with PVD visited to OPD of the vascular department was enrolled in the study. Data was collected as per the Case Record Form.
Results: The mean age was found to be 58.4 ± 11.3 years of total 100 patients. An improvement in a Doppler testing (follow-up at the time interval after 1 month, 3 months and 6 months) and increased in peak systolic velocity in distal vessels as well as collaterals were observed in all patients. The PVD was prevalent in 50 to 60 years of age groups and hypertension and smoking were the most common risk factors present in PVD patients. There was more than 70% increase in walking distance after 24 weeks of treatment. Headache 24 (36.4%) and Dizziness 9 (13.6%) were observed as common side effect of therapy. The total cost of the combination therapy was affordable with improved quality of life.
Conclusion: The combination treatment showed symptomatic improvement in peripheral vascular disease in the study. The peak systolic velocity gradually increased in the distal vessel and the combination was found to be cost-effective.
Comparison of Illness Behavior between Japanese and Chinese Patients with Somatoform Disorders
Authors: Takegishi Tomoko , Yamamoto Noriko , Hirabayashi Naoki , Hasuzawa Suguru , Koda Masahide , Huang Zhengguo , Li Na , Matsuo Hisae , Sato Takeshi 
Published: September 2022

Aims: To clarify the differences between Japan and China regarding illness behavior of outpatients with somatoform disorders.
Study Design: Cross-sectional study.
Place and Duration of Study: A survey on psychiatric and psychological outpatients with somatoform disorders between Japan and China. Duration of this study was three months between April 1, 2011, and June 30, 2011.
Methodology: The subjects of this research included 43 Japanese outpatients (49.7±10.5 yr., M/F:13/30) in psychiatry clinic at Saga Medical School Hospital, Saga 845-8502, Japan. It also included 38 Chinese outpatients (40.7±8.2 yr., M/F: 14/24) in psychiatry and psychology outpatient clinic in Dalian Medical University Hospital, Liaoning province, China. All psychiatric patients were diagnosed as the somatoform disorders according to the DSM-IV. To investigate the difference of psychological status and illness behavior, we examined them using two psychological instruments: Illness Behavior Questionnaire (IBQ) and General Health Questionnaire-30 (GHQ-30).
Results: It can be found that there were the remarkable statistical differences between the Japanese and Chinese patients with somatoform disorders of each of the subscales of the GHQ-30. All GHQ-30 items were scored significantly higher by the Chinese than by the Japanese. Regarding the IBQ, the statistical differences of five subscales of IBQ between the two groups: General Hypochondriasis, Disease Conviction, Affective Inhibition, Affective Disturbance, and Irritability can be found. No obvious difference was found between the two groups of the subscale of Psychological versus somatic focusing (P/S) and Denial (D), however.
Conclusion: The GHQ-30 and the other five subscales of IBQ (except for P/S and D) for Chinese was higher than for Japanese. This finding may be attribute to the socio-cultural and economic factors. P/S and D scores on the IBQ were not significantly different, suggesting the possibility of an essential symptom of somatoform disorders.
A Statistical Analysis and Exploration on Atlantic Hurricanes Database (HURDAT2); Do We Expect the Worst?
Authors: Nyabuga Douglas Omwenga , Alfred Mukuru Ssessazi 
Published: September 2022

Hurricane occurrence exploration is a heavy task that requires sophisticated methods to accurately determine the occurrence and the impact of damage on the tropical environs. To control massive damage, several techniques have been developed to measure the accuracy of track forecasting. The accurate analysis and exploration of the occurrence of hurricanes are very crucial for the affected environs evaluation within a short time to minimize the loss of human life and property. Nevertheless, the exact analysis and exploration of these hurricanes is challenging and time-consuming. Therefore, this study proposed a statistical model whereby the analysis of variance (ANOVA) a linear regression scientific data statistical analysis model is applied on the dataset of Atlantic hurricane database (HURDAT2) for the exploration of hurricane occurrence and damage in the tropical environs. The best tracks of a 6 hour interval, location (latitude, and longitude), wind speed, central pressure of all identified hurricanes and subtropical typhoons from the year 2008 to 2017 (10 year period) are used to determine the R2 coefficient, which measures the goodness and fitness of the model to reveal the variability of the real data. Statistical significance and reliability of the data are tested on significance P-value <0.05 where four different parameters are considered for the analysis in order to determine the destructive of these hurricanes in the tropical environs; latitude (x1), longitude (x2), the wind speed (x3), and central pressure. The results of our model proved significant with an accuracy of 99.3%, and a mean standard error (MSE) of 1.4952 for all the hurricanes that were analyzed, and the year 2012 was established as a year that had much damage.
Production and Quality Assessment of Biscuit from Acha Flour Supplemented with Pigeon Pea
Authors: Adeyanju James Abiodun , Alabi Olubunmi Dupe , Abioye Adekanmi Olusegun , Oloyede Abiola Adewale , Korede Olayinka Idayat 
Published: September 2022

This research work evaluates the production of biscuits from blends of acha and pigeon pea flour. Acha and pigeon pea flour were blended in the ratio 95:5, 90:10, 85:15, 80:20 and 100:0 (control) to produce biscuits. Biscuits made from this blend were analyzed for proximate analysis, antinutrient composition, physical attributes, and sensory qualities. The moisture, protein, fat, crude fiber, ash, and carbohydrate content of the biscuits ranged from 7.87-9.84%, 7.36-8.14%, 21.99-26.33%, 0.39-0.59%, 0.87-1.24%, and 58.06-63.01%, respectively. The antinutrient composition varied from 4.24-6.82% for tannin and 3.85-4.68% for phytate. The physical attributes of the biscuits ranged from 8.34-10.98 g, 0.56-0.85 cm, 4.77-5.03, 5.99-8.59 for weight, thickness, diameter and spread ratio, respectively. The sensory evaluation showed that the biscuit sample with the blend ratio of 95% and 5% (acha to pigeon pea flour) was the most acceptable because it gave the best colour, appearance, crispness and overall acceptability. The result shows that acceptable biscuits with improved nutritional attributes can be produced from the blend of acha and pigeon pea flour. This will eliminate or reduce the problems associated with protein-energy malnutrition common in most local communities, and reduce wheat importation, thereby increasing the use of the most underutilized sources of flour in most developing countries.
Urban Resiliency towards Climate Change
Authors: Debangshi Udit , Ghosh Pritam , Tiwari Himanshu , Maurya Durgesh Kumar , Kumar Manoj 
Published: September 2022

India will experience massive urbanization in the coming decades, with the country's urban population expected to double by 2050. Climate change is a major threat to urban systems all over the world. Its consequences are expected to worsen over the next few decades. The consequences of climate changes are more in urban areas than rural due to rapid urbanization, health issue, decreasing water level and industrialization etc. Climate change consequences such as increased rainfall intensity, storm surges, temperature fluctuation and flooding are expected to have a global impact on urban health, sustainability, coastal areas, urban infrastructure, migrants, ecosystems and urban water use. On the other hand, humanity able to take collective action to mitigate the severity of these impacts. Mitigation and adaptation strategies, such as climate resilient agriculture, rooftop farming, extreme weather mitigation, resilient water use and so on, will almost certainly be required to deal with these effects. It is encouraging to note that urban planning has the potential to play a key role in developing and implementing adaptive responses in urban systems. The benefit of urban planning is sustainable and required some urban planning regimes around the world which include, plan-making, stakeholder engagement, development management and design standards to make a better and greener urban ecosystem.
Successful Treatment of Recalcitrant Non-genital Warts (Verruca vulgaris) with a Topical Solution Containing Two Antivirals and a Low Concentration of Salicylic Acid
Authors: Pereira Ricardo de Souza , Monteiro Nayana Mendes 
Published: September 2022

Aims: Commercial formulas for the treatment of warts use salicylic acid in concentrations above 100 mg/ml, which causes skin irritation, and the results are often unsatisfactory. To address this problem, we developed a new formula with a low concentration of salicylic acid (20 mg/ml) and with the addition of virucidal compounds (metallic iodine and benzoic acid) and compared it to a formula currently on the market (Verrux®) containing 165 mg salicylic acid (0.165 g) and 145.2 mg lactic acid (0.145 g) per ml collodion.
Study Design: A randomized double-blind study was conducted.
Location and Duration of Study: Department of Biotechnology, UNINCOR, Chácara das Rosas, Três Corações, MG, Brazil; School of Pharmacy, Universidade Federal do Amapá - Campus Universitário Marco Zero do Equador, Rod. Juscelino Kubitschek, KM-02, Jardim Marco Zero, Macapá, AP, Brazil and School of Medicine, Universidad Politécnica y Artística del Paraguay (UPAP), Km 10, Ciudad del Este, Paraguay, between December 2004 and October 2016.
Methodology: 95 patients were treated with the formula with salicylic acid (20mg), benzoic acid (20mg) and metallic iodine (2.5mg) per ml (group A) and 95 received treatment with Verrux® (salicylic acid 165mg, lactic acid 145.2mg per ml collodion) (group B).
Results: All patients in Group A (100%) reported complete resolution of signs and symptoms after 13 weeks of treatment. In contrast, 67 subjects (70.5%) in group B reported regression of symptoms during the same period.
Conclusion: There was a statistically significant difference between the groups studied here (P< 0.05). This new formulation with a low level of salicylic acid and two virucidal agents promotes healing of recalcitrant cutaneous warts without significant side effects. The price of the two formulas is virtually the same (about $8 to $10 each bottle).
Catalase‐Mimetic Artificial Biocatalysts with Ru Catalytic Centers for ROS Elimination and Stem‐Cell Protection
Authors: Sun Yimin , Mu Shengdong , Xing Zhenyu , Guo Jiusi , Wu Zihe , Yu Fanyuan , Bai Mingru , Han Xianglong , Cheng Chong , Ye Ling 
Published: September 2022

AbstractExploring high‐efficiency reactive oxygen species (ROS)‐elimination materials is of great importance for combating oxidative stress in diverse diseases, especially stem‐cell‐based biotherapeutics. By mimicking the FeN active centers of natural catalase, here, an innovative concept to design ROS‐elimination artificial biocatalysts with Ru catalytic centers for stem‐cell protection is reported. The experimental studies and theoretical calculations have systematically disclosed the activity merits and structure diversities of different Ru sites when serving as ROS‐elimination artificial biocatalysts. Benefiting from the metallic electronic structures and synergetic effects of multiple sites, the artificial biocatalysts with Ru cluster centers present exceptional ROS‐elimination activity; notably, it shows much higher catalytic efficiency per Ru atom on decomposing H2O2 when compared to the isolated single‐atom Ru sites, which is more efficient than that of the natural antioxidants and recently reported state‐of‐the‐art ROS‐scavenging biocatalysts. The systematic stem‐cell protection studies reveal that the catalase‐like artificial biocatalysts can provide efficient rescue ability for survival, adhesion, and differentiation functions of human mesenchymal stem cells in high ROS level conditions. It is suggested that applying these artificial biocatalysts with Ru cluster centers will offer a new pathway for engineering high‐performance ROS‐scavenging materials in stem‐cell‐based therapeutics and many other ROS‐related diseases.
Timing of potassium chloride application effect on soil and potato uptake of chloride
Authors: Light Sarah E. , Sullivan Dan M. , Horneck Donald A. 
Published: September 2022

AbstractPotassium chloride (KCl) is often used to supply K for potato (Solanum tuberosum L.) production; it is the least costly K fertilizer. However, crop uptake of Cl can reduce diagnostic petiole NO3–N and reduce tuber specific gravity. This trial evaluated the effect of K fertilizer source (KCl vs. sulfate of potash [SOP] and sulfate of potash magnesia [KMag]) and fertilizer application timing on Cl, S, N, and K in soil, petioles, and whole plant biomass. Fertilizers were applied at 224 kg K2O ha–1 at three application timings: 210 d before planting (fall preplant), 14 d before planting (spring preplant), or 35 d after planting (Layby) to a sandy loam soil in Hermiston, OR. Nitrogen fertilizer was applied by overhead sprinklers during the growing season. Potassium source and timing had minimal effect on crop S, N, and K uptake. Crop Cl response reflected a fertilizer source × timing interaction. Fall‐applied KCl did not increase plant Cl above that observed for KMag and SOP treatments. Spring or summer‐applied KCl increased plant Cl concentrations. The most likely explanation for this response pattern was leaching of Cl below rooting depth with fall fertilizer application. Findings of importance for potato production practices in our region included: (a) fall‐applied Cl was not taken up by the crop, and so did not represent a risk to potato tuber quality; (b) elevated concentrations of petiole Cl from preplant or in‐season KCl application did not affect petiole NO3–N.
Different organic material amendments effects soil nitrogen utilization and crop yield in the North China Plain
Authors: Chen Lin , Du Hailun , Liu Qing , Li Teng , Sui Peng , Gao Wangsheng , Chen Yuanquan 
Published: September 2022

AbstractOrganic materials incorporation and nitrogen utilization are both important measures to enhance soil fertility and crop productivity. To evaluate the effect of different organic materials on soil N utilization and crop yield, three kinds of organic materials, including straw (ST), pig manure (PM), and biogas residue (BR), were incorporated into the soil with equal N in the wheat (Triticum aestivum L.)–maize (Zea mays L.) cropping system with chemical fertilizers (CFs) as a control in Wuqiao County in the North China Plain. The contents of soil N, nitrate N, ammonium N, N use efficiency, N partial productivity (NPFP), N uptake efficiency (NUPE), and N harvest index (NHI) were measured and calculated. The results of 2‐yr field trials suggested that, compared with CF, soil total N (TN) content of ST, PM, and BR treatment increased by 3.04, 8.99, and 9.10%, respectively. An even larger increase was found in nitrate N, which was 25.87, 44.67, and 44.93% in ST, PM, and BR, respectively. For N utilization, PM significantly increased NPFP, NUPE, and NHI by 4.01, 5.86, and 3.04%, respectively, meanwhile decreasing soil N dependency rate by 4.64%; BR improved NUPE by 5.15%, while ST showed little improvement in the utilization of soil N. Overall, organic materials promoted soil N maintenance and increased N utilization. Among the kinds of organic material amendment in the study, PM had a better performance in improving soil N utilization and crop yield than BR and crop ST return in field experiments.
Clinical exome sequencing uncovers a high frequency of Mendelian disorders in infants with stroke: A retrospective analysis
Authors: Kumar Runjun D. , Meng Linyan , Liu Pengfei , Miyake Christina Y. , Worley Kim C. , Bi Weimin , Lalani Seema R. 
Published: September 2022

AbstractStroke causes significant disability and is a common cause of death worldwide. Previous studies have estimated that 1%–5% of stroke is attributable to monogenic etiologies. We set out to assess the utility of clinical exome sequencing (ES) in the evaluation of stroke. We retrospectively analyzed 124 individuals who received ES at the Baylor Genetics reference lab between 2012 and 2021 who had stroke as a major part of their reported phenotype. Ages ranged from 10 days to 69 years. 8.9% of the cohort received a diagnosis, including 25% of infants less than 1 year old; an additional 10.5% of the cohort received a probable diagnosis. We identified several syndromes that predispose to stroke such as COL4A1‐related brain small vessel disease, homocystinuria caused by CBS mutation, POLG‐related disorders, TTC19‐linked mitochondrial disease, and RNASEH2A associated Aicardi‐Goutieres syndrome. We also observed pathogenic variants in NSD1, PKHD1, HRAS, and ATP13A2, which are genes rarely associated with stroke. Although stroke is a complex phenotype with varying pathologies and risk factors, these results show that use of exome sequencing can be highly relevant in stroke, especially for those presenting <1 year of age.
Deep learning‐based prediction of treatment prognosis from nasal polyp histology slides
Authors: Wang Kanghua , Ren Yong , Ma Ling , Fan Yunping , Yang Zheng , Yang Qintai , Shi Jianbo , Sun Yueqi 
Published: September 2022

AbstractBackgroundHistopathology of nasal polyps contains rich prognostic information, which is difficult to extract objectively. In the present study, we aimed to develop a prognostic indicator of patient outcomes by analyzing scanned conventional hematoxylin and eosin (H&E)‐stained slides alone using deep learning.MethodsAn interpretable supervised deep learning model was developed using 185 H&E‐stained whole‐slide images (WSIs) of nasal polyps, each from a patient randomly selected from the pool of 232 patients who underwent endoscopic sinus surgery at the First Affiliated Hospital of Sun Yat‐Sen University (internal cohort). We internally validated the model on a holdout dataset from the internal cohort (47 H&E‐stained WSIs) and externally validated the model on 122 H&E‐stained WSIs from the Seventh Affiliated Hospital of Sun Yat‐Sen University and the University of Hong Kong‐Shenzhen Hospital (external cohort). A poor prognosis score (PPS) was established to evaluate patient outcomes, and then risk activation mapping was applied to visualize the histopathological features underlying PPS.ResultsThe model yielded a patient‐level sensitivity of 79.5%, and specificity of 92.3%, with areas under the receiver operating characteristic curve of 0.943, on the multicenter external cohort. The predictive ability of PPS was superior to that of conventional tissue eosinophil number. Notably, eosinophil infiltration, goblet cell hyperplasia, glandular hyperplasia, squamous metaplasia, and fibrin deposition were identified as the main underlying features of PPS.ConclusionsOur deep learning model is an effective method for decoding pathological images of nasal polyps, providing a valuable solution for disease prognosis prediction and precise patient treatment.
Scrutiny of physico‐chemical properties of extractant‐diluent phase: Keystone of extraction systems
Authors: Sahu Rakesh Kumar , Pradhan Sanghamitra , Mishra Sujata 
Published: September 2022

AbstractSolvent extraction is one of the hydro metallurgical techniques adopted due to its ease for efficient separation of metal ions. The separation and extraction of metals are enabled using privileged metal distribution between the aqueous and organic phase. Commercially available solvent extractants and recently the designer solvents like ionic liquids have gained adequate attention in the area of separation science for the retrieval of different metal ions. Diluents play an important role by ensuring the improved hydrodynamics of the extraction system. The physico‐chemical characteristics of the organic phase solution need to be scrutinized thoroughly in order to optimize the extraction conditions. Investigation on the interaction between extractant and diluent at molecular level is vital for the assessment of extraction efficiency. Density, viscosity, dielectric constant, refractive index, conductivity, and acoustic properties provide evidence on the molecular organizations between these unlike molecules. The aim of this review is to project on the importance of physical, chemical, and thermodynamic properties for fabricating an efficient combination of extractants‐diluents to achieve maximum extraction output.
Design and Syntheses of Ruthenium ENE (E = S, Se) Pincer Complexes: A Versatile System for Catalytic and Biological Applications
Authors: Bhatt Surabhi , Meena Neha , Kumar Mukesh , Bhuvanesh Nattamai , Kumar Anil , Sharma Anuj K. , Joshi Hemant 
Published: September 2022

AbstractThis report describes the synthesis of two ruthenium(II) ENE pincer complexes (E = S, C1 and E = Se, C2) by the reaction of bis(2‐(phenylchalcogenyl)ethyl)amine (L1, L2) with RuCl2(PPh3)3. The complexes were characterized with the help of 1H and 13C{1H} NMR, FTIR, HRMS, cyclic voltammetry and elemental analysis techniques. The structure and bonding mode of ligand with ruthenium in C2 was established with the help of single crystal X‐ray diffraction. The complex showed distorted octahedral geometry with two chlorine atoms trans to each other. The Ru−Se bond distances (Å) are 2.4564(3)‐2.4630(3), Ru−N distance is 2.181(2), Ru−P distance is 2.2999(6), and Ru−Cl distances are 2.4078(6)‐2.4314(6). The complexes showed good to excellent catalytic activity for the N‐alkylation of o‐phenylenediamine with benzyl alcohol derivatives to synthesize 1,2‐disubstituted benzimidazole derivatives. The complexes were also found to be efficient for aerobic oxidation of benzyl alcohols to corresponding aldehydes which are precursors to the bisimines generated in situ during the synthesis of 1,2‐disubstituted benzimidazole derivatives. Complex C2 where selenium is coordinated with ruthenium was found to be more efficient as compared to sulfur coordinated ruthenium complex C1. Since ruthenium complexes are getting increasing attention for developing new anticancer agents, the preliminary studies like binding behavior of both the complexes towards CT‐DNA were studied by competitive binding with ethidium bromide (EthBr) using emission spectroscopy. In addition, the interactions of C1−C2 were also studied with bovine serum albumin (BSA) using steady state fluorescence quenching and synchronous fluorescence studies. A good stability of Ru(II) state was observed by cyclic voltammetric studies of C1−C2. Overall these molecules are good examples of bio‐organometallic systems for catalytic and biological applications.