bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Nomogram for Predicting Cancer-Specific Survival in Children With Wilms Tumor: A Study Based on SEER Database and External Validation in China
Authors: Tan Xiaojun , Wang Jinkui , Tang Jie , Tian Xiaomao , Jin Liming , Li Mujie , Zhang Zhaoxia , He Dawei 
Published: April 2022

BackgroundWilms tumor (WT) is the most common tumor in children. We aim to construct a nomogram to predict the cancer-specific survival (CSS) of WT in children and externally validate in China.MethodsWe downloaded the clinicopathological data of children with WT from 2004 to 2018 in the SEER database. At the same time, we used the clinicopathological data collected previously for all children with WT between 2013 and 2018 at Children's Hospital of Chongqing Medical University (Chongqing, China). We analyzed the difference in survival between the patients in the SEER database and our hospital. Cox regression analysis was used to screen for significant risk factors. Based on these factors, a nomogram was constructed to predict the CSS of children with WT. Calibration curve, concordance index (C-index), the area under the receiver operating curve (AUC) and decision curve analysis (DCA) was used to evaluate the accuracy and reliability of the model.ResultsWe included 1,045 children with WT in the SEER database. At the same time, we collected 112 children with WT in our hospital. The Kaplan-Meier curve suggested that children in China with WT had a higher mortality rate than those in the United States. Cox regression analysis revealed that age, lymph node density (LND), and tumor stage were significant prognostic factors for the patients in the SEER database. However, the patients in our hospital only confirmed that the tumor stage and the number of positive regional lymph nodes were significant factors. The prediction model established by the SEER database had been validated internally and externally to prove that it had good accuracy and reliability.ConclusionWe have constructed a survival prognosis prediction model for children with WT, which has been validated internally and externally to prove accuracy and reliability.
Identification of a Four-Gene Metabolic Signature to Evaluate the Prognosis of Colon Adenocarcinoma Patients
Authors: Zheng Yang , Wu Rilige , Wang Ximo , Yin Chengliang 
Published: April 2022

BackgroundColon adenocarcinoma (COAD) is a highly heterogeneous disease, thus making prognostic predictions uniquely challenging. Metabolic reprogramming is emerging as a novel cancer hallmark that may serve as the basis for more effective prognosis strategies.MethodsThe mRNA expression profiles and relevant clinical information of COAD patients were downloaded from public resources. The least absolute shrinkage and selection operator (LASSO) Cox regression model was exploited to establish a prognostic model, which was performed to gain risk scores for multiple genes in The Cancer Genome Atlas (TCGA) COAD patients and validated in GSE39582 cohort. A forest plot and nomogram were constructed to visualize the data. The clinical nomogram was calibrated using a calibration curve coupled with decision curve analysis (DCA). The association between the model genes' expression and six types of infiltrating immunocytes was evaluated. Apoptosis, cell cycle assays and cell transfection experiments were performed.ResultsUnivariate Cox regression analysis results indicated that ten differentially expressed genes (DEGs) were related with disease-free survival (DFS) (P-value&lt; 0.01). A four-gene signature was developed to classify patients into high- and low-risk groups. And patients with high-risk exhibited obviously lower DFS in the training and validation cohorts (P &lt; 0.05). The risk score was an independent parameter of the multivariate Cox regression analyses of DFS in the training cohort (HR &gt; 1, P-value&lt; 0.001). The same findings for overall survival (OS) were obtained GO enrichment analysis revealed several metabolic pathways with significant DEGs enrichment, G1/S transition of mitotic cell cycle, CD8+ T-cells and B-cells may be significantly associated with COAD in DFS and OS. These findings demonstrate that si-FUT1 inhibited cell migration and facilitated apoptosis in COAD.ConclusionThis research reveals that a novel metabolic gene signature could be used to evaluate the prognosis of COAD, and targeting metabolic pathways may serve as a therapeutic alternative.
Evaluation of Surgical Treatment Effect on Idiopathic Normal Pressure Hydrocephalus
Authors: Sun Ran , Ning Haibo , Ren Ning , Xing Xiuying , Chen Xuejiao , Li Guihua , Li Xin , Chen Lei 
Published: April 2022

Background:We aimed to observe the long-term effectiveness and safety of the ventriculoperitoneal (VP) shunt in treating idiopathic normal pressure hydrocephalus (iNPH).MethodsA total of 65 patients with iNPH were retrospectively analyzed. All the patients were treated with VP shunt and the clinical efficacy was assessed using follow-up questionnaire, the Modified Rankin Scale (mRS), and iNPH grading scale (iNPHGS) after operation.ResultsThe mean mRS and iNPHGS scores were 1.18 ± 0.83 points and 2.98 ± 1.96 points, respectively, which were statistically significantly different from those before operation [(2.89 ± 0.92) points and (6.49 ± 2.30) points, respectively]. Besides, the patients were divided into the non-improvement group (n = 8, 12.3%), the improvement group (n = 16, 24.6%), and the marked improvement group (n = 41, 63.1%) based on the preoperative and postoperative mRS scores and the total effective rate of the VP shunt was 87.7%. Next, seven patients with negative cerebrospinal fluid tap test (tap test) received the active VP shunt and the score on walking disorder was 2.71 ± 0.76 points before operation and 1.86 ± 0.90 points after operation, showing a statistically significant difference. Moreover, 12 (18.4%) patients had complications after operation, among whom 5 (7.7%) patients manifested ameliorated symptoms after replacing shunt tube and receiving anti-infection treatment, but 3 (4.6%) patients showed no alleviation following pressure adjustment due to advanced age and multiple complications. Six (9.2%) cases of death were recorded during follow-up and only 1 (1.5%) case of sudden death occurred within 2 weeks after operation. In addition, it was found through more than 5 years of follow-up after operation that 12 out of the 23 (52.2%) patients had a good effect at 5 years after operation, 1 (4.3%) patient had been confined to bed due to advanced age and pulmonary infection, and 1 (4.3%) patient died of pulmonary infection and heart failure.ConclusionThe VP shunt is effective in treating iNPH and it results in a preferable long-term prognosis.
Gestión urbana para la calidad de vida de los pobladores, Morro Solar – Jaén
Authors: Vigo Terrones Nancy , Pesantes Carrasco Edgar Francisco , Pérez Astonitas Roberto 
Published: April 2022

Conceptualmente el carácter público de un servicio implica en su definición un derecho de la comunidad, de manera independiente del modelo de gestión en que se base y de quien esté a cargo. Este carácter implica la necesidad de garantizar de algún modo, las condiciones de acceso y mantenimiento para el conjunto de la población, independientemente de su lugar de residencia, condiciones territoriales, de su vinculación de la propiedad del suelo, condiciones institucionales y condiciones económicas. Sobre esa base todo servicio tiene un claro efecto en las definiciones de las condiciones de la calidad de vida de los pobladores. Para ello, el estudio tuvo como propósito diagnosticar la calidad de vida de los pobladores de Morro Solar de la Provincia de Jaén. Para ello se utilizó un tipo de investigación descriptiva con un enfoque cuantitativo, un diseño transversal no experimental; asimismo se obtuvo una muestra probabilística de 50 personas; para la cual se han utilizado las técnicas de la encuesta y la entrevista. Según los hallazgos se tiene que la calidad de vida de los pobladores, es de nivel regular en el 64%, la mayoría de ellos demanda atención a sus necesidades para mejorar su bienestar físico, emocional y desarrollo personal; el nivel de gestión urbana que implementa el municipio, según el 74% de encuestados, es medianamente adecuado, por tanto, la gestión urbana del gobierno local requiere ser mejorada.
Microbiota, probióticos y el comportamiento humano
Authors: Fuenmayor-González Luis , Fajardo-Loaiza Thalía , Rivadeneira-Dueñas Josué , Arévalo-Mancheno Juan 
Published: April 2022

En la actualidad, ha cobrado una gran importancia la relación que la microbiota intestinal mantiene con varios órganos y sistemas del cuerpo humano. Particularmente importante, son las relaciones de la microbiota con el Sistema Nervioso Central, el comportamiento y el desarrollo y tratamiento de varias enfermedades. La relación existente entre la microbiota intestinal y el cerebro se produce gracias a la actividad de estímulos neuroendocrinos y neuroinmunes que pueden actuar de forma bilateral, llegando incluso a generar modificaciones en el comportamiento del ser humano. Del mismo modo, a través de la realización de estudios clínicos y paraclínicos, se ha conseguido demostrar la asociación entre el eje microbiota-intestino-cerebro y trastornos neurológicos como la enfermedad de Parkinson o el trastorno depresivo. El objetivo del presente artículo es realizar un análisis de los principales estudios identificados en relación a la función del eje microbiota-intestino-cerebro (MIC) así como identificar la nueva evidencia acerca del uso de probióticos en el tratamiento coadyuvante de varios trastornos neuro-psiquiátricos. Se realizó una búsqueda sistemática de la bibliografía utilizando palabras claves y términos MeSH y se presentó en formato de discusión de acuerdo a los subtemas: eje microbiota-intestino-cerebro, mecanismos de acción, microbiota y su relación con el comportamiento y regulación sobre probióticos. Se concluyó que existe evidencia que demuestra la relación entre el eje microbiota-intestino-cerebro y varios trastornos neuropsiquiátricos en el ser humano. Además, que la administración de probióticos puede modificar el eje MIC y pueden constituir una alternativa de terapia coadyuvante en estos trastornos del comportamiento.
Capacidad de resistencia a la compresión con agregados alternativos aligerantes en concreto convencional
Authors: Cárdenas Gutiérrez JA , Jácome Carrascal José Leonardo , Vergel Ortega Mawency 
Published: April 2022

La industria de la construcción es una de las industrias más contaminantes que existen a nivel global, debido a la empleabilidad de los materiales que se necesitan y la cantidad de procedimientos industriales para su conformación, lo cuales generan altos índices de CO2 a nuestra atmosfera contribuyen de manera sustancial a la problemática actual del calentamiento global.
Así mismo, los productos plásticos son una amenaza inminente para los ecosistemas, por lo tanto, la utilización de estos productos como el poliestireno expandido permiten atacar dos problemas ambientales mientras se solucionan problemáticas específicas como una problemática social que se solucione mediante una obra de ingeniería civil.
Por lo tanto, en esta investigación se determina el aporte que realiza este material reciclable con respecto a las propiedades mecánicas del concreto, tratando de evidenciar los niveles de aporte o disminución que existen al cambiar parte del agregado grueso por este material alternativo.
Incidencia de la recesión económica en el sector hotelero ocasionada por la pandemia.
Authors: Cárdenas García Maribel , Cañizares Arévalo Jorge de Jesús , Paz Montes Luisa Stella 
Published: April 2022

A partir de la declaratoria de la pandemia por la Organización mundial de la salud (OMS), la economía del país se vio fuertemente afectada por la cuarentena y el cierre de todos los sectores económicos, entre ellos el hotelero, quien fue uno de los más afectados. Esta situación puso en jaque a dicho sector, donde fue necesario en cierto modo reinventarse y generar estrategias para no perder sus clientes actuales y potenciales, los clientes o turistas que venían regularmente a la ciudad de Cúcuta.
El Departamento Norte de Santander no escapa a esta realidad y a esto se suma que el sector de servicios de alojamiento ya venía enfrentando problemas desde el año 2015 derivados del cierre de la frontera con Venezuela lo cual estaba afectando la ocupación del sector, pero en la etapa pandémica de acuerdo con datos consultados en el Centro de Información Turística (CITUR) del Ministerio de Industria y Comercio de Colombia y el DANE (2020, agosto) la ocupación hotelera del Norte de Santander alcanzó el 2,1% afectando fuertemente las finanzas del sector.
Para conocer el impacto del confinamiento en dicho sector, se realizó una investigación de tipo cualitativo, con un diseño no experimental de tipo transversal. La reducción de turistas ha debilitado toda la cadena turística, especialmente a los hoteles, los cuales debido al distanciamiento social y a los protocolos de bioseguridad, han visto enormemente disminuido el alquiler de los salones y demás sitios de recreación y esparcimiento que ofrecen en el mismo.
Authors: SYAIFUDIN Achmad , Natsir Imam Muhsin , Kuswanto Djoko 
Published: April 2022

The extrusion process of 3D printer filament from recycled plastics has various challenges in the effort to produce quality filaments. One of the important factors affecting the filament quality is the diameter tolerance of the extruded filament that should be within the range of Â±0,05mm. To produce those filaments, good consistency of the extrusion process is required. The most influential component of the extrusion machine is the screw. In this study, the screw was modified to overcome fluctuations in filament diameter. The polymer material was polypropylene (PP) that comes from recycled plastics. Firstly, the temperature, electric current of the motor, and screw rotation speed were observed to determine systemic fluctuations due to the surging phenomenon. Thereafter, the filament diameter was observed by direct measurement with a vernier caliper and macro-observation to seek defects. Furthermore, to overcome filament fluctuations due to imperfection in the mixing process, the screw was modified by adding a Maddock mixer that its undercut depth had been modified. The undercut depth variations are 0.1 mm (0.04D), 0.5 mm (0.02D), and 1.2 mm (0.47D). This research showed that the modification of undercut depth on the Maddock mixer did not improve the quality of filament diameter produced. Meanwhile, the undercut depth variations on the Maddock mixer affected the capacity of extrusion.
Classificação de livro (Book Classification)
Authors: Sales Rodrigo de , Monteiro de Barros Camila 
Published: April 2022

O artigo aqui traduzido, originalmente intitulado Book Classification, publicado na segunda metade do século XIX, no periódico norte-americano The Journal of Speculative Philosophy (v. 4, n. 2, 1870, p. 114-129), é de autoria do filósofo e educador reformista, também norte-americano, William Torrey Harris (1835-1909). Ao tornar público um sistema de classificação de livros desenvolvido pelo próprio Harris para a rede de bibliotecas das escolas públicas da cidade de St. Louis (USA), o artigo acabou exercendo uma influência definitiva na história da construção das classificações bibliográficas, no período que marca a virada do século XIX para o século XX. Ao propor um arranjo de livros inspirado pela narrativa de Francis Bacon (faculdades mentais = memória, imaginação e razão), mas conduzido teoricamente pela perspectiva hegeliana que dá primazia à razão, e, portanto, à Filosofia e à Ciência, a classificação de Harris ganhou notoriedade na América do Norte e serviu de base para a construção da Classificação Decimal de Dewey que, por sua vez, se tornaria uma das mais influentes classificações bibliográficas do mundo ocidental. A importância histórica e teórica da classificação de Harris motivou a tradução deste artigo, originalmente escrito em inglês americano, para a língua portuguesa do Brasil. É importante frisar que os tradutores procuraram ao máximo manter a estilística do texto do autor, própria do século XIX.
Kant et l’Afrique: deux rendez-vous manqués? Une approche psychologique développementale
Authors: SOSOE Lukas K. 
Published: April 2022

Kant et l’Afrique ? Que signifie la question? Que contient-elle et que cache-t-elle tout à la fois ? Qu’est-ce qui motive l’interrogation si nous partons de l’hypothèse qu’aucun ouvrage ou aucun opuscule de Kant ne se réfère à l’Afrique explicitement, qu’il n’y a pas, dans l’œuvre de Kant, plus de références à l’Afrique qu’à d’autres continents et que l’Afrique, il y a deux cents ans, était trop éloignée de Kant qui n’était pas des plus grands voyageurs de son temps ?
Penerapan RapidMiner dengan Metode K-Means dalam Penentuan Kluster Ganguan Jaringan WIFI Provider PT.XYZ di Daerah Karawang
Authors: Pratama Putra Julius Widianto , Suganda Erik Arfan , Purnamasari Intan 
Published: April 2022

Jaringan internet pada era ini merupakan suatu kebutuhan masyarakat. Internet digunakan untuk memudahkan pekerjaan manusia dalam segala bidang, baik itu komunikasi, tranportasi hingga edukasi. Internet tidak hanya didapatkan melalui layanan kartu GSM (Global System for Mobile Communications) perdana yang digunakan oleh tiap smartphone untuk terhubung dengan internet. Adapun teknologi Wifi yang digunakan untuk memancarkan internet sehingga smartphone bisa tersambung dengan internet tanpa perlu kartu GSM. Salah satu perusahaan di karawang yang menyediakan layanan Wifi yaitu PT XYS Karawang. Ada 20 daerah yang menjadi jangkauan layanan Wifi dari PT XYS di Karawang. Pada pengoperasian layanan Internet Wifi pasti ada gangguan yang terjadi pada layanan Internet Wifi PT XYS. Pada penelitian ini penulis ingin melakukan pengelompokan gangguan Internet yang terjadi di daerah karawang dengan menggunakan Metode Clustering untuk pengelompokan data ganggunan. Dengan menentukan nilai titik pusat atau Centroid yang berjumlah Centroid 3 maka dapat dibentuk menjadi 3 cluster. 3 cluster yang terbentuk akan memberikan informasi daerah apa saja yang menjadi Cluster tingkat tinggi (C1), Cluster tingkat sedang (C2), dan Cluster tingkat rendah (C3). Hal ini dapat memberikan informasi kepada PT xyz agar mengetahui daerah apa saja yang perlu penanganan lebih agar dapat mengurangi masalah gangguan Internet Wifi yang tinggi agar berkurang.
Agresi Militer Belanda di Wilayah Batu Pujon 1947-1948: Sebuah Kajian Sejarah Lokal
Authors: Mahardika Moch. Dimas Galuh 
Published: April 2022

Abstrak: Peristiwa yang menandai periode 1945-1950 adalah Agresi Militer I dan II oleh pemerintah Belanda dengan mengerahkan berbagai divisi militer sebagai upaya merebut kembali tanah jajahan. Keinginan besar Belanda untuk mendapatkan kekuasaan kembali atas Indonesia setelah proklamasi merupakan salah satu bentuk ancaman nyata yang harus dihadapi oleh bangsa Indonesia. Dengan dalih "Aksi Polisionil", tentara Belanda melakukan aktifitas militer di wilayah Indonesia, sekaligus melanggar perjanjian yang telah disepakati sebelumnya. Gejolak di berbagai daerah mulai muncul, salah satunya terjadi di wilayah Batu-Pujon. Monumen status quo lijn di daerah Pujon menjadi simbol batas pendudukan Belanda dan wilayah Republik. Pertempuran yang terjadi di wilayah Batu-Pujon merupakan salah satu dari sekian banyak pertempuran yang terjadi selama periode Agresi Militer. Artikel ini ditulis dengan menggunakan metode penelitian sejarah untuk menceritakan peristiwa Agresi Militer Belanda dalam konteks sejarah lokal wilayah Batu- Pujon.Kata Kunci: Agresi, Militer, Belanda, Batu, Pujon, TNI.Abstract: One of the events marking the period 1945-1950 was the Military Aggression I and II which deployed many military divisions in an effort to fight for independence in the regions. The Dutch&#39; great desire to regain control of Indonesia after the proclamation is one form of real threat that must again be faced by the Indonesian nation. Under the pretext of "Police Action", the Dutch soldiers carried out military activities while violating a previously agreed agreement. Turmoil in various regions began to appear, one of them in the Batu-Pujon region which is one of the highlands and flanked by several mountains. The status quo monument in Pandesari area became a symbol of the boundaries of dutch occupation and Republic territory. The battle that took place in the Batu-Pujon region was a small battle that took place during the Military Aggression. This article written by using the historical research methods try to explain the history of Dutch Military Agression in the local history context of Batu-Pujon region. Keywords: Agression, Batu, Pujon, Indonesian, National, Army.
A Systematic Review of Ensemble Techniques for Software Defect and Change Prediction
Authors: Khanna Megha 
Published: April 2022

Background: The use of ensemble techniques have steadily gained popularity in several software quality assurance activities. These aggregated classifiers have proven to be superior than their constituent base models. Though ensemble techniques have been widely used in key areas such as Software Defect Prediction (SDP) and Software Change Prediction (SCP), the current state-of-the-art concerning the use of these techniques needs scrutinization.
Aim: The study aims to assess, evaluate and uncover possible research gaps with respect to the use of ensemble techniques in SDP and SCP.
Method: This study conducts an extensive literature review of 77 primary studies on the basis of the category, application, rules of formulation, performance, and possible threats of the proposed/utilized ensemble techniques.
Results: Ensemble techniques were primarily categorized on the basis of similarity, aggregation, relationship, diversity, and dependency of their base models. They were also found effective in several applications such as their use as a learning algorithm for developing SDP/SCP models and for addressing the class imbalance issue.
Conclusion: The results of the review ascertain the need of more studies to propose, assess, validate, and compare various categories of ensemble techniques for diverse applications in SDP/SCP such as transfer learning and online learning.
ASPEK-ASPEK PSIKOLOGI UPACARA RITUAL LALUHAN PADA MASYARAKAT DAYAK NGAJU
Authors: Anggreni Fiona , Pudjibudojo Jatie K. 
Published: April 2022

Abstract. This literature study aims to explain the tradition of the Laluhan ceremony from a psychological perspective especially in the aspects of commitment and conformity of the Dayak Ngaju tribe. The Laluhan ritual is a process of delivering goods / assistance to the place where Tiwah's death party is held. Based on the beliefs of the Dayak Ngaju tribe, it will have a good impact when equipping the spirits of ancestors and families who have passed away to lewu tatau (heaven). In the process of implementing Bakas Tiwah as the customary leader in charge of conveying the types and quantities of Laluhan items to families and communities. Through Laluhan, social influence is carried out on their offspring and encourages the community to become conformists in the group to do the same thing and try to fulfill the commitment to achieve the group's goals. The Benefits of Research contribute knowledge to the public about the culture of death in Central Kalimantan.
Keywords: Dayak ngaju, Laluhan, ritual ceremony