bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applicability of the Padua scale for Chinese rheumatic in-patients with venous thromboembolism
Authors: Peng Qing , Chen Xixi , Han Yaxin , Tang Guo , Liu Jiajun , Liu Yan , Zhou Qiao , Long Li 
Published: December 2022

Objective
To investigate the risk factors for venous thromboembolism (VTE) in hospitalized patients with rheumatic diseases in China. The efficacy of the Padua scale was evaluated and an improved model for predicting VTE in hospitalized patients with rheumatic diseases was developed.

Methods
Records of 2282 patients hospitalized in the department of rheumatology of the Sichuan Provincial People’s Hospital were retrospectively reviewed. The risk factors for VTE were analyzed. The efficacy of the Padua scale was evaluated, Padua-combined prediction model and the independent risk factor-combined prediction model for predicting VTE were assessed using the receiver operating curve (ROC).

Results
A total of 50 patients in the VTE group and 2232 in the non-VTE group were included. Antiphospholipid syndrome (APS), VTE history, a hospital stay of over 3 days, high D-dimer (D-D), and decreased serum albumin were independent risk factors for VTE. APS was very closely associated with VTE (OR = 19.446). Padua scores in the VTE group and the non-VTE group were 3 (2, 6) and 2 (1, 2) points, respectively (p < 0.05), and the proportion of high-risk patients were 48.0% and 7.4%, respectively (p < 0.05). The incidence of VTE in the high-risk (Padua score ≥4) and low-risk (Padua score <4) groups was 12.7% and 1.2%, respectively (p < 0.05). The area under curve (AUC) of the Padua scale, Padua combined prediction model (Padua scale along with D-D and serum albumin), and the independent risk factor-combined prediction model was 0.771, 0.836, and 0.873, respectively.

Conclusion
The Padua scale has limited predictive efficacy of VTE in hospitalized rheumatic patients. The independent risk factor-combination prediction model was superior in predicting VTE compared to Padua scale and Padua-combined prediction model.
Directed content analysis: A life course approach to understanding the impacts of the COVID-19 pandemic with implications for public health and social service policy
Authors: Purkey Eva , Bayoumi Imaan , Davison Colleen M. , Watson Autumn 
Published: December 2022

Background
The COVID-19 pandemic has had broad impacts on individuals, families and communities which will continue to require multidimensional responses from service providers, program developers, and policy makers.

Objectives
The purpose of this study was to use Life Course theory to understand and imagine public health and policy responses to the multiple and varied impacts of the COVID-19 pandemic on different groups.

Methods
“The Cost of COVID-19” was a research study carried out in Kingston, Frontenac, Lennox and Addington counties in South Eastern Ontario, Canada, between June and December 2020. Data included 210 micronarrative stories collected from community members, and 31 in-depth interviews with health and social service providers. Data were analyzed using directed content analysis to explore the fit between data and the constructs of Life Course theory.

Results
Social pathways were significantly disrupted by changes to education and employment, as well as changes to roles which further altered anticipated pathways. Transitions were by and large missed, creating a sense of loss. While some respondents articulated positive turning points, most of the turning points reported were negative, including fundamental changes to relationships, family structure, education, and employment with lifelong implications. Participants’ trajectories varied based on principles including when they occurred in their lifespan, the amount of agency they felt or did not feel over circumstances, where they lived (rural versus urban), what else was going on in their lives at the time the pandemic struck, how their lives were connected with others, as well as how the pandemic impacted the lives of those dear to them. An additional principle, that of Culture, was felt to be missing from the Life Course theory as currently outlined.

Conclusions
A Life Course analysis may improve our understanding of the multidimensional long-term impacts of the COVID-19 pandemic and associated public health countermeasures. This analysis could help us to anticipate services that will require development, training, and funding to support the recovery of those who have been particularly affected. Resources needed will include education, mental health and job creation supports, as well as programs that support the development of individual and community agency.
Factors that influence the pancreatic and duodenal microbiome in patients undergoing pancreatic surgery
Authors: Zwart Eline S. , Jeleniewski Suzanne , Boyd Lenka N. C. , Meijer Laura L. , Puik Jisce R. , Zonderhuis Barbara M. , Daams Freek , Budding Andries E. , Mebius Reina E. , Kazemier Geert 
Published: December 2022

Background/Objectives
This study examined the correlation between pancreatic microbiome and patients characteristics. Furthermore, we compared different duodenal materials to examine their reflection of the pancreatic microbiome.

Methods
Patients undergoing pancreatic surgery were included in the study. Characteristics of those patients were prospectively registered and sterile pancreatic biopsies were collected during surgery. After completion of the resection, duodenal fluid, -tissue and -swab were collected. Bacterial DNA was extracted and analyzed with IS-pro assay.

Results
Paired samples of 51 patients were available for evaluation, including pancreatic biopsies from all patients, 22 duodenal fluids, 21 duodenal swabs and 11 duodenal tissues. The pancreatic microbiome consisted mostly of Proteobacteria followed by Firmicutes, Actinobacteria, Fusobacteria and Verrucomicrobia (FAFV) and Bacteroidetes. On species level, Enterococcus faecalis, Escherichia coli, and Enterobacter-Klebsiella were most abundant. In pancreatic biopsies, the total bacterial load and Proteobacteria load were significantly higher in patients with biliary drainage (54618.0 vs 5623.5; 9119.0 vs 2067.1). Patients who used proton pump inhibitors had a significantly higher total bacterial load (115964.7 vs 8495.8), more FAFV (66862.9 vs 1890.1), more Proteobacteria (24245.9 vs 2951.4) and more Bacteroidetes (542.5 vs 25.8). The head of the pancreas contained significantly more bacteria (21193.4 vs 2096.8) and more FAFV (5225.7 vs 19.0) compared to the tail, regardless of biliary drainage. Furthermore, the microbiome of all duodenal materials showed a weak correlation with the pancreatic microbiome.

Conclusion
Biliary drainage, use of proton pump inhibitors, and anatomic location of the pancreatic biopsy influence the pancreatic microbiome. Furthermore, the duodenal microbiome does not suffice as a surrogate for the pancreatic microbiome.
Prevalence and correlates of teenage pregnancy among in-school teenagers during the COVID-19 pandemic in Hoima district western Uganda–A cross sectional community-based study
Authors: Musinguzi Marvin , Kumakech Edward , Auma Anne Grace , Akello Ruth Anne , Kigongo Eustes , Tumwesigye Raymond , Opio Bosco , Kabunga Amir , Omech Bernard 
Published: December 2022

Background
The COVID-19 pandemic related restrictions and lockdown measures had compromised the routine delivery and access of sexual and reproductive health and rights services to the population including the teenage girls. However, the teenage pregnancy rates during COVID-19 pandemic period were poorly documented. This study aimed at determining the prevalence and the factors associated with teenage pregnancy among in-school teenage girls during the COVID-19 pandemic period in Hoima District Uganda.

Methods
This was a descriptive cross-sectional study that employed quantitative research methods. A total of 314 in-school teenage girls aged 13–19 years were selected using a multi-stage sampling techniques. Interviewer-administered questionnaires were used to collect the data from the participant’s homes during the period December 2021-January 2022. Data analysis was done using univariate, bi-variate, and multivariate.

Results
The prevalence of teenage pregnancy among the in-school teenage girls in Hoima district Uganda was 30.6% [96/314]. Higher teenage pregnancy rates were prevalent among the unmarried teenage girls [aOR: 9.6; 95%CI: 4.64–19.87; p = 0.000], teenage girls studying from boarding schools [aOR 2.83, 95%CI 1.36–5.86, p = 0.005], contraceptive non-users [aOR: 2.54; 95%CI: 1.12–5.4; p = 0.015] and teenage girls involved in sex trade [aOR 3.16, 95%CI 1.5–6.7, p = 0.003]. The factors associated with the reduced likelihood for teenage pregnancy included being an adult teenage girl aged 18–19 years [aOR: 0.15; 95%CI: 0.07–0.32; p = 0.000] and not receiving sex education during the period [aOR 0.36, 95%CI 0.13–0.62, p = 0.024].

Conclusion
The results indicated that 3 out of 10 in-school teenage girls from Hoima district Uganda got pregnant during the COVID-19 pandemic period of 2021. Teenage pregnancy was prevalent among teenage girls who don’t use modern contraceptive methods and those involved in sex trade. Teenage pregnancy was however, less prevalent among adult teenage girls aged 18–19 years. The findings point to the need for health stakeholders to innovate creative policies, contingency plans and programmes aimed at delaying age for sexual activities, increasing contraceptive use and minimizing pregnancy risk from sex trade among in-school teenage girls during COVID-19 pandemics.
Contingency management to promote smoking cessation in people experiencing homelessness: Leveraging the electronic health record in a pilot, pragmatic randomized controlled trial
Authors: Molina Melanie F. , Hall Sharon M. , Stitzer Maxine , Kushel Margot , Chakravarty Deepalika , Vijayaraghavan Maya 
Published: December 2022

Background
Cigarette smoking is disproportionately high among people experiencing homelessness (PEH). Contingency management (CM) is a strategy that has shown considerable efficacy for smoking cessation and has been used in short-term studies of smoking abstinence in PEH. We describe a pilot, pragmatic randomized controlled trial protocol, which leverages an electronic health record (EHR) infrastructure to assess the feasibility and acceptability of an extended CM intervention to improve long-term abstinence in PEH.

Methods
We will conduct the study at three safety-net clinics in San Francisco among 90 adults experiencing homelessness who smoke cigarettes currently and have a desire to quit. We will encourage all participants to receive smoking cessation services that include behavioral counseling and pharmacotherapy through their clinics. We will randomly assign participants to an extended CM intervention group with escalating incentives contingent on abstinence or to a control group with fixed incentives for attending study visits. We will use the EHR to recruit participants, track receipt of counseling and pharmacotherapy during clinical care, and communicate with providers on participants’ progress. CM participants will get escalating incentives for demonstration of carbon monoxide-verified abstinence over 6 months, with a total possible earnings of $475. Control participants will receive a fixed incentive of $5 for attending study visits, totaling $125. We will conduct the carbon-monoxide verified abstinence assessments—which will determine CM incentive amounts—daily during week 1, bi-weekly through week 4, weekly through week 13, and monthly through week 24. Measures of feasibility and acceptability, both quantitative and qualitative, will include assessments of screening and recruitment, adherence to study visits, engagement in smoking cessation clinical care, retention, and participant satisfaction. One of the primary clinical outcomes will be biochemically verified 7-day point prevalence abstinence at 6 months. We will measure secondary outcomes, which will include 7-day point prevalence abstinence at 2 weeks, 3 and 12 months.

Discussion
This trial will allow us to assess the feasibility and acceptability of a CM cessation intervention among PEH. The protocol’s clinical setting and use of EHRs gives it significant potential for scalability. If found to be feasible, acceptable, and subsequently efficacious in a larger trial, the intervention could reduce tobacco-related health disparities by increasing long-term smoking abstinence among this vulnerable population.

Trial registration
ClinicalTrials.gov NCT04982952. Registered on July 29, 2021.
Ten-year persistence and evolution of Plasmodium falciparum antifolate and anti-sulfonamide resistance markers pfdhfr and pfdhps in three Asian countries
Authors: Srisutham Suttipat , Madmanee Wanassanan , Kouhathong Jindarat , Sutawong Kreepol , Tripura Rupam , Peto Thomas J. , van der Pluijm Rob W. , Callery James J. , Dysoley Lek , Mayxay Mayfong , Newton Paul N. , Pongvongsa Tiengkham , Hongvanthong Bouasy , Day Nicholas P. J. , White Nicholas J. , Dondorp Arjen M. , Imwong Mallika 
Published: December 2022

Background
The amplification of GTP cyclohydrolase 1 (pfgch1) in Plasmodium falciparum has been linked to the upregulation of the pfdhfr and pfdhps genes associated with resistance to the antimalarial drug sulfadoxine-pyrimethamine. During the 1990s and 2000s, sulfadoxine-pyrimethamine was withdrawn from use as first-line treatment in southeast Asia due to clinical drug resistance. This study assessed the temporal and geographic changes in the prevalence of pfdhfr and pfdhps gene mutations and pfgch1 amplification a decade after sulfadoxine-pyrimethamine had no longer been widely used.

Methods
A total of 536 P. falciparum isolates collected from clinical trials in Thailand, Cambodia, and Lao PDR between 2008 and 2018 were assayed. Single nucleotide polymorphisms of the pfdhfr and pfdhps genes were analyzed using nested PCR and Sanger sequencing. Gene copy number variations of pfgch1 were investigated using real-time polymerase chain reaction assay.

Results
Sequences of the pfdhfr and pfdhps genes were obtained from 96% (517/536) and 91% (486/536) of the samples, respectively. There were 59 distinct haplotypes, including single to octuple mutations. The two major haplotypes observed included IRNI-AGEAA (25%) and IRNL-SGKGA (19%). The sextuple mutation IRNL-SGKGA increased markedly over time in several study sites, including Pailin, Preah Vihear, Ratanakiri, and Ubon Ratchathani, whereas IRNI-AGEAA decreased over time in Preah Vihear, Champasak, and Ubon Ratchathani. Octuple mutations were first observed in west Cambodia in 2011 and subsequently in northeast Cambodia, as well as in southern Laos by 2018. Amplification of the pfgch1 gene increased over time across the region, particularly in northeast Thailand close to the border with Laos and Cambodia.

Conclusion
Despite the fact that SP therapy was discontinued in Thailand, Cambodia, and Laos decades ago, parasites retained the pfdhfr and pfdhps mutations. Numerous haplotypes were found to be prevalent among the parasites. Frequent monitoring of pfdhfr and pfdhps in these areas is required due to the relatively rapid evolution of mutation patterns.
The role of oxidative stress in neurodegenerative diseases and potential antioxidant therapies
Authors: Sienes Bailo Paula , Llorente Martín Elena , Calmarza Pilar , Montolio Breva Silvia , Bravo Gómez Adrián , Pozo Giráldez Adela , Sánchez-Pascuala Callau Joan J. , Vaquer Santamaría Juana M. , Dayaldasani Khialani Anita , Cerdá Micó Concepción , Camps Andreu Jordi , Sáez Tormo Guillermo , Fort Gallifa Isabel 
Published: December 2022

Abstract

Objectives
The central nervous system (CNS) is essential for homeostasis and controls the physiological functions of the body. However, the biochemical characteristics of the CNS make it especially vulnerable to oxidative damage (OS). This phenomenon compromises correct CNS functioning, leading to neurodegeneration and neuronal death.

Contents
OS plays a crucial role in the physiopathology of neurodegenerative diseases. It is involved in multiple mechanisms of nucleic acid, protein, and lipid oxidation, thereby contributing to progressive brain damage. These mechanisms include mitochondrial dysfunction; excessive production of reactive oxygen and nitrogen species; deficiency of antioxidant defenses; protein oligomerization; cytokine production and inflammatory response; blood–brain barrier abnormalities; and proteasome dysfunction. All these dysfunctions are involved in the pathogenesis of neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, or amyotrophic lateral sclerosis.

Summary and outlook
A curative treatment is currently not available. Research is focused on the search for therapies that reduce oxidative damage and delay disease progression. In the recent years, researchers have focused their attention on the effects of antioxidant therapies.
The usefulness of implementing minimum retest intervals in reducing inappropriate laboratory test requests in a Dutch hospital
Authors: Boerman Anneroos W. , Al-Dulaimy Muhammad , Bandt Yvonne C. , Nanayakkara Prabath W.B. , de Jonge Robert 
Published: December 2022

Abstract

Objectives
Inappropriate use of laboratory testing remains a challenging problem worldwide. Minimum retest intervals (MRI) are used to reduce inappropriate laboratory testing. However, their effectiveness and the usefulness in reducing inappropriate laboratory testing is still a matter of debate. The aim of this study was to evaluate the effectiveness of broadly implemented MRIs as a means of reducing inappropriate laboratory test requests.

Methods
We performed a retrospective study in a general care and teaching hospital in the Netherlands, where MRI alerts have been implemented as standard care since June 7th 2017. Clinical chemistry test orders in adult internal medicine patients placed between July 13th 2017 and December 31st 2019 were included. The primary outcome was the effectiveness of MRIs, expressed as percentages of tests ordered and barred as a result of MRIs.

Results
Of a total of 218,511 test requests, 4,159 (1.90%) got an MRI alert. These MRIs were overruled by physicians in 21.76% of the cases. As a result of implementing MRIs, 3,254 (1.49%) tests were barred. The financial savings for the department of internal medicine directly related to the included barred laboratory tests during this period were 11,880 euros on a total amount of 636,598 euros for all performed tests.

Conclusions
Only a small proportion of laboratory tests are barred after implementation of MRIs, with a limited impact on the annual costs. However, MRIs provide a continuous reminder to focus on appropriate testing and the effectiveness of MRIs is potentially higher than described in this study.
Holding Friends Closer or Keeping Them at a Distance: The Intimacy with Founding Members and Its Effect on Entrepreneurs’ Effectual Problem Setting
Authors: Yang Zhi , Yang Jinglan 
Published: December 2022

Abstract
Whether founding with friends will affect entrepreneurs’ venturing model? Based on construal level theory, this study shows a fresh look into entrepreneurs’ intimacy with other founding members and its effects on their cognition of ongoing venturing projects. We argue that the stronger intimacy with other founding members shortens the perceived psychological distance between an entrepreneur and an ongoing project, thus lowering the entrepreneur’s construal level. The construal level mediates the effect on the problem space the entrepreneurs perceive. Using two-wave survey data from 162 Chinese founding teams, we find that the strong intimacy with other founding members results in less effectual problem setting through lower construal level. Moreover, the indirect effect is moderated by venturing team size in the way that a large venturing team size will weaken the effect. From the construal level theory perspective, our findings may explain why and how founding with friends may affect the venturing model choice and highlight the importance of entrepreneurs’ surrounding relationships within founding teams. This study also provides some potential practical implications for the entrepreneurs when founding with friends.
Stancetaking in the U.S. Supreme Court’s abortion jurisprudence (1973-present): epistemic (im)probability and evidential (dis)belief
Authors: McKeown Jamie 
Published: December 2022

AbstractThis article investigates stancetaking by judicial opinion writers in the U.S. Supreme Court’s abortion jurisprudence. It examines the performative use of two kinds of stance evaluations, i.e., epistemic (im)probability and evidential (dis)belief. Using several sub-corpora, it contrasts the previously mentioned stance evaluations in majority opinions (168,329 words) and dissent opinions (105,517 words), thus contributing to a further understanding of the common law phenomenon of separate opinion writing. In light of the court’s decision to overrule this area of law and return it to the state level, this article also contrasts the use of performative stance evaluations in relation to two key jurisprudential issues: viability and state interests. The results show that dissent writers used a significantly greater number of stance evaluation markers. Although confidence levels varied across the different results, dissent writers also used significantly greater amounts of high certainty/strength markers when responding to majority opinions. This represented a kind of discursive escalation in which dissent writers diverged from majority opinions and expressed stronger counterstances. The article closes with a discussion of the major implications for the current law and directions for discourse research in a post-Roe legal landscape.
Thermal explosion synthesis of Cr2AlB2 materials
Authors: Zhao He , Yin Xu , Wang Yanhong 
Published: December 2022

Abstract
Ternary conductive ceramic Cr2AlB2 phase has been widely studied because of its unique physical and chemical properties. However, the preparation of conventional synthetic Cr2AlB2 requires expensive raw materials or higher equipment cost, which is not conducive to its synthesis and promotion. Hence, we synthesized high-content Cr2AlB2 by thermal explosion reaction, a technology with low-energy consumption. Cr2AlB2 was synthesized by thermal explosion reaction from Cr/Al/B mixed powders. The effects of different ignition materials and diamond additive on Cr2AlB2 synthesis were studied systematically. Results showed that the Cr/Al/B system did not undergo a thermal explosion reaction. An aluminothermic reaction between Al and Cr2O3 occurred by introducing a small amount of Cr2O3. The main phase of the thermal explosion products of the Cr/Al/B/Cr2O3 green body was CrB. The addition of an appropriate amount (7.5 % and 10 %) of diamond in the raw material can obviously promote Cr2AlB2 synthesis. The main phases of the product were Cr2AlB2 and CrB. The samples were composed of a large number of fine Cr2AlB2 lath grains. Finally, the mechanism of Cr2AlB2 formation by thermal explosion reaction was proposed.