bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Maltese Single Transferable Vote Experience: A Case Study of Gerrymandering?
Authors: Hasancebi Serhat 
Published: October 2022

Abstract
Re-drawing the electoral boundaries to provide benefit to one particular political party and thereby damaging the principle of representation in democracy has been a core issue in political science in the recent years. For years social scientists have been advocating the idea of measuring or preventing the potential for damage that may arise from the existence of the above-mentioned redistricting process. Following this discussion, we investigate the possible gerrymandering phenomenon that might have arisen, or whether there are any asymmetries or partisan biases due to boundary delimitation of the electoral constituencies in the case of the Maltese general elections. From the evidence of various statistical tests and simulations, our conclusion is that we find no evidence of gerrymandering in the 2013 and 2017 Maltese general elections.
JEL codes: K16
Closed-form algebraic expressions for monoprotic weak acid dissolutions
Authors: Caicedo Anthony J. , Morales Juan C. , Arango Carlos A. 
Published: October 2022

Abstract
Closed-form algebraic expressions for the pH of ideal weak acid and weak acid buffer solutions (and their titration with a strong base) were obtained and analyzed with the aid of computer algebra systems. These expressions are used to evaluate, without the use of numerical approximations, the precision and accuracy of different approximations commonly employed to calculate the pH. The closed-form expression for the pH of a buffer solution is used to obtain an analytical expression for the pH stability when a strong base is added. Finally, it is shown that the pH expressions for all the systems under study can be obtained from an unique closed-form expression in terms of an effective weak acid constant and an effective acid concentration.
Modeling Dynamics of the Spread of Crime with Media Impact
Authors: Goswami Naba Kumar , Athithan S. 
Published: October 2022

Abstract
A non-linear mathematical model is developed and analyzed in order to investigate the interactions between the criminal and non-criminal populations while taking into account the influence of media on the non-criminal class. We obtained the basic reproduction number of the model while taking into account constant recruitment and death type demography. The model’s equilibria have been examined , and their stabilities have been thoroughly addressed. The backward bifurcation is presented for basic reproduction number less than one. Sensitivity analysis is conducted on the proposed model to determine the key parameters of basic reproduction number of the model.These model is further expanded to an optimum control problem to investigate the effects of time-dependent crime control rate on the size of the criminal population using Pontryagin’s maximum principle. To demonstrate our analytical findings, we present numerical simulations.
Rotational stability and refractive outcomes of the DFT/DATx15 toric, extended depth of focus intraocular lens
Authors: Barber Kevin M. , O’Connor Sara , Mackinder Philip , Chih Andreea , Jones Brian 
Published: October 2022

Abstract
Purpose: To quantitatively assess postoperative rotational stability and visual acuity with the DFT/DATx15 extended depth of focus (EDOF) toric intraocular lens (IOL).
Methods: In this prospective case series, thirty-five patients with a calculated IOL power between +15.0 D and +25.0 D, corneal astigmatism between 0.75 D and 2.25 D, and no significant ocular pathology underwent cataract surgery. Primary outcome was rotational stability of the IOL at 1 month post-operatively. Secondary outcomes included residual refractive astigmatism, absolute residual astigmatism prediction error, and monocular distance and intermediate visual acuities.
Results: Mean absolute postoperative IOL rotation was 1.1 ± 0.2 degrees, with no rotation of more than 3 degrees at the final visit. Monocular mean best spectacle-corrected distance visual acuity (BSCDVA) improved from logMAR 0.27 ± 0.030 to 0.078 ± 0.017 (P < .001). Monocular uncorrected distance visual acuity (UCDVA) improved from 0.93 ± 0.096 to 0.18 ± 0.022 (P < .001). Best spectacle-corrected intermediate visual acuity (DSCIVA) was 0.17 ± 0.025, and uncorrected intermediate visual acuity (UCIVA) was 0.27 ± 0.040. Residual regular astigmatic refractive error was 0.21 ± 0.047 D.
Conclusions: The toric DFT/DATx15 EDOF lens showed excellent rotational stability and effective and predictable correction of astigmatism. Its refractive outcomes and safety profile were similar to those identified in prior studies of the non-toric DFT/DAT015 EDOF IOL. A small difference in monocular BSCDVA, of uncertain clinical significance, was found when comparing these outcomes with prior DFT/DAT015 data. The trial was retrospectively registered on November 5, 2021 (TRN ​​NCT05119127).
Speech and music recruit frequency-specific distributed and overlapping cortical networks
Authors: Rietmolen Noemie te , Mercier Manuel , Trebuchon Agnes , Morillon Benjamin , Schon Daniele 
Published: October 2022

Abstract

To what extent do speech and music processing rely on domain-specific and domain-general neural networks? Adopting a dynamical system framework, we investigate the presence of frequency-specific and network-level selectivity and combine it with a statistical approach in which a clear distinction is made between shared, preferred, and category-selective neural responses. Using intracranial EEG recordings in 18 epilepsy patients listening to natural and continuous speech and music, we show that the majority of focal and network-level neural activity is shared between speech and music processing. Our data also reveal an absence of regional selectivity. Instead, neural selectivity is restricted to dis- tributed and frequency-specific coherent oscillations, typical of spectral fingerprints. Our work addresses a longstanding debate and redefines an epistemological posture on how to map cognitive and brain functions.
Influence of pre-gravid preparation on the course and outcomes of the pregnancy in genital herpes
Authors: Mikhailova O. I. , Kan N. E. , Mirzabekova D. D. , Tyutyunnik V. L. 
Published: October 2022

Introduction. According to researchers from different countries, the incidence of neonatal herpes varies noticeably. Objective. Optimization of pre-gravid preparation of women with chronic recurrent genital herpes to reduce pregnancy complications and improve perinatal outcomes. Мaterials and methods. The study included 58 women with confirmed chronic recurrent genital herpes. Two groups were formed, the main group included 30 women receiving pre-gravid preparation, complex treatment with antiviral and immunomodulatory drugs, the comparison group was represented by 28 women receiving pre-gravid preparation and only antiviral drug. Evaluation of the effectiveness of the treatment of chronic genital herpes and the benefits of pre-gravid preparation were carried out by assessing clinical manifestations, determining the immune status, analyzing the characteristics of the course of pregnancy, childbirth, and perinatal outcomes. Results. As a result of the study, the available data confirm the feasibility of using complex therapy in the treatment of chronic recurrent genital herpes in combination with pre-gravid preparation. Conclusion. Pre-gravid preparation and specific treatment of women with chronic recurrent genital herpes improve the clinical status of patients, increase the interrecurrent period, reduce the severity of prodromal symptoms, the duration and intensity of relapses of the disease, and contribute more favorable course of pregnancy and improvement perinatal outcomes.
Inosine pranobex in the treatment of mild cervical intraepithelial neoplasia (experience of clinical use)
Authors: Borovikov I. O. , Kutsenko I. I. , Bulgakova V. P. , Gorbulina A. A. 
Published: October 2022

Introduction. The article reflects the experience of treating patients with papillomavirus- associated lesion of the cervix – mild cervical intraepithelial neoplasia (CIN I) with the use of an immunostimulant with antiviral activity – inosine pranobex (tablets 500 mg) with an assessment of clinical and microbiological efficacy. Aim. Evaluation of the effectiveness of immunomodulatory and antiviral therapy in patients with mild cervical intraepithelial neoplasia with a drug containing inosine pranobex. Materials and methods. An analysis of treatment with a drug containing inosine pranobex (tablets 500 mg) of 78 women with CIN I (36 months of monitoring) was carried out. Methods: colposcopy, histological examination of biopsy specimens of cervical areas, Pap-test, PCR HPV (qualitative and quantitative), immunohistochemical (determination of markers p16ink4D, Ki-67). Results. Presented experience of therapy with three-year monitoring of patients diagnosed with CIN I am using an oral immunostimulant with antiviral activity – inosine pranobex – (1000 mg 3 times a day for 28 days 1 time per year, showed its high clinical (84.2 %) and microbiological (83.3 %) efficacy with satisfactory tolerability of the drug. Сonclusion. Immunotropic and nonspecific antiviral monotherapy with an oral inosine pranobex drug showed high clinical (recovery of colposcopic status – 83.3 %, cytohistologically confirmed absence of CIN in cervical scrapings – 85.9 %) and microbiological (PCR-negative HPV – 83.3 %) efficacy during the three-year monitoring.
Features of eating behavior in women: experience of observation with an assessment of the risk of predicted complications
Authors: Shevlyukova T. P. , Mateykovich E. A. , Ermakova P. A. , Ermakova A. A. 
Published: October 2022

Introduction. Studies show that up to 8 % of pregnant women suffer from eating disorders. Such problems are found everywhere, most often women do not even realize that this may be related to problems. And for pregnant women, this issue is most relevant, since there is a risk of complications of the gestation period, after which it is necessary to prevent unfavorable variants of the course of pregnancy and childbirth. Aim. To study the variants of eating disorders in pregnant women to assess the prognosis of pregnancy. Materials and methods. We conducted a retrospective analysis of clinical case histories of pregnant women (n = 267), followed by a survey of women on the basis of the State Medical Institution “Maternity Hospital No. 2” in Tyumen. The study period is from 2019–2022. Two groups were identified for the analysis: 1st – BMI of 18.5–24.9 kg/m2 : 2nd – BMI of 25 kg/m2 or more. In order to determine the type of eating disorder, we used various versions of questionnaires. Results. Of the total number of women surveyed, overweight (BMI) was determined in 149/267 (55.9 %, 2 group), in 118/267 (44.1 %, 1 group), BMI was within normal values. Risk factors were identified for the groups that could affect the course of the gestational process in the case of an identified eating disorder. When assessing comorbidity, gynecological diseases were detected, pathologies were significantly more common for group 2 62/149 (41.6 %). The dependence of the presence of a violation of any type of eating behavior and the risk of possible complications of pregnancy is not statistically significant. Conclusions. To maximize the favorable course of pregnancy and reduce the risk of possible complications, it is necessary to prepare a plan of preventive measures, which will include nutrition planning with a detailed description of solutions for a certain type of eating disorder.
AVALIAÇÃO PÓS-OCUPAÇÃO (APO) APLICADA EM UM AMBIENTE ADMINISTRATIVO NO INTERIOR DE PARQUE FABRIL AUTOMOBILÍSTICO
Authors: ACCIOLI MARTA ELISA RIEKSTIN , ORNSTEIN SHEILA WALBE 
Published: October 2022

O artigo foi resultante de uma pesquisa de mestrado desenvolvida e concluída junto ao Programa de Pós-Graduação da Faculdade de Arquitetura e Urbanismo da Universidade de São Paulo, com o objetivo de investigar as decisões de projeto adotadas, e seus resultados, em um ambiente de escritórios inserido em um edifício administrativo de um parque fabril automobilístico. O edifício estudo de caso elegido para a pesquisa, construído em 1985, possui cerca de 13.500m² de área útil e, em 2015, passou por um processo de retrofit interno, com renovação nos seus conceitos de ocupação e com novas configurações dos seus ambientes. As investigações foram realizadas por meio da aplicação dos instrumentos indicados nos procedimentos metodológicos da Avaliação Pós-Ocupação (APO), reunindo um conjunto amplo de métodos e técnicas (quantitativos e qualitativos), de forma a explorar os instrumentos, sob o ponto de vista do especialista, e as experiências e necessidades dos usuários. O trabalho conduziu a um diagnóstico sistêmico, com o entendimento das soluções implantadas, apresentando possíveis melhorias para os espaços avaliados e servindo de subsídios para arquitetos, facilities managers e gestores, na realimentação de projetos futuros semelhantes e na gestão dos ambientes de trabalho, especialmente no caso deste estudo, mas com potencial de contribuições para outros estudos de caso afins.

PALAVRAS-CHAVE: avaliação pós-ocupação; escritórios; parque fabril
Is There Any Collaborative Governance on Post-disaster Social Policy in Banten Province?
Authors: Thahir Baharuddin 
Published: October 2022

Social policies include increased social protection, approaches to improving living standards, and access to decent work. The description discusses two concepts, namely collaborative governance and the concept of social policy. Methodologically and technically, the two concepts are side by side in the context of implementing decentralization policies. Collaborative governance as collaboration is a relationship designed to solve a problem through the creation of solutions in conditions that are full of limitations (Ansell & Gash, 2008). At the same time, the social policy responds to social problems, which tends to ignore the assessment of some people that they are not in a socially problematic condition (Spicker, 2014). social policy has many forms, such as health, education, housing, and other social services. The method uses a descriptive qualitative and qualitative verification analysis strategy model. Post-disaster handling, collaborative governance is applied through the government's efforts to carry out recovery that focuses on the residential, economic, infrastructure, social and cross-sectoral sectors. The results also show obstacles in collaborative governance, such as delays in building houses for the community, mismatch of specifications between what was promised and what was received by the community, and low public understanding. This study also shows that post-disaster management collaborative governance can be implemented using several strategies divided by sector and sub-sector; the right communication pattern increases community involvement in the entire post-disaster management process in Banten province. All strategies would be better if packaged in the form of government innovation. This means that post-disaster management, especially in repair and development efforts, is an important agenda for government collaboration.
Clinical Utility of a Digital Therapeutic Intervention in Indian Patients With Type 2 Diabetes Mellitus: 12-Week Prospective Single-Arm Intervention Study
Authors: Chawla Rajeev , Jaggi Shalini , Gupta Amit , Bantwal Ganapathi , Patil Suhas 
Published: October 2022

Background
Patients with type 2 diabetes mellitus (T2DM) having elevated levels of blood glucose and glycated hemoglobin (HbA1c) are at higher risk of macro- and microvascular complications. Nonetheless, the goal of achieving glycemic control cannot be met with the use of pharmacotherapy alone. The recent emergence of digital therapeutic tools has shown the possibility of improving the modifiable risk factors and self-management of diabetes.

Objective
The aim of this study was to examine the clinical utility of a digital therapeutic intervention as an add-on therapy to achieve glycemic control in patients with T2DM.

Methods
This was a 12-week prospective, single-arm digital intervention study in patients with T2DM receiving regular antidiabetic treatment. The eligibility criteria included male and female patients with HbA1c≥6.5%, functional English literacy, and a mobile phone capable of running the intervention app. Outcome measures of the study were mean changes in HbA1c, fasting blood glucose (FBG), postprandial blood glucose (PPBG), BMI, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index at the end of 12 weeks.

Results
A total of 128 participants completed the study period of 12 weeks. There were 54.7% (70/128) men and 45.3% (58/128) women with a mean age of 48.48 years (SD 10.27). At the end of 12 weeks, the mean change in HbA1c, FBG, PPBG, and BMI for the overall study population was –0.84% (P<.001), –8.39 mg/dl (P=.02), –14.97 mg/dl (P<.001), and –0.24 kg/m2 (P=.06), respectively. Among the participants showing improvement in the HbA1c value at the end of 12 weeks (responders), the mean change in HbA1c, FBG, PPBG, and BMI was –1.24% (P<.001), –12.42 mg/dl (P=.003), –21.45 mg/dl (P<.001), and –0.34 kg/m2 (P=.007), respectively. There was an increase in HOMA-IR values for the overall study population (0.54, P=.29). HbA1c response showed a significant association with a baseline HbA1c level ≥7.5%, no prior history of smoking, and no prior COVID-19 infection, as well as with higher levels of program engagement.

Conclusions
A digital therapeutic intervention when used alongside standard medications significantly reduces HbA1c, FBG, and PPBG levels in patients with T2DM.
Formulation and Evaluation of Floating Tablets of Pantoprazole
Authors: Vinod M , Chetankumar M , Bote Somanath , Kolageri Shivanand 
Published: October 2022

Background: Pantoprazole is a protein pump inhibitor (PPI) used to treat acute duodenal ulcers, acute benign gastric ulcers, gastroesophageal reflux disease (GERD), and as a preventative measure for duodenal ulcer. It has a local effect on the stomach and works by competitively inhibiting the enzyme H+/K+ ATP, which is found in the gastric parietal cells. For acute duodenal ulcers, acute benign gastric ulcers, and gastroesophageal reflux disease (GERD), the usual oral dosage recommendation is 45 mg, and it is taken for 8–12 weeks.
Objectives: The preparation of pantoprazole floating tablets was attempted in the current investigation and optimize the formulation using different excipients like Hydroxy ethyl cellulose (HEC), cyclodextrin, sodium bicarbonate, citric acid and microcrystalline cellulose were used in the direct compression method to create pantoprazole floating tablets (250 mg).
Methods: The direct compression method has been used in the current effort to create floating tablets. The active ingredient, sodium bicarbonate, citric acid, microcrystalline cellulose, and hydroxy ethyl cellulose were sieved through sieve no. 60 and blended uniformly with a mortar and pestle. Using a Rotary tablet punch machine, the powder was compacted into tablets after talc and magnesium stearate were added as lubricants
Results: Preformulation studies were conducted to select suitable excipients, drug/polymer interactions were validated by the FTIR investigation. The manufactured floating tablets were assessed for hardness, weight fluctuation, thickness, friability, drug content homogeneity, floating lag time, and in vitro dissolution experiment studies was conducted. The results were within the limit and were compared with the marketed formulation.
Conclusion: According to the observations of the current investigation, a floating pantoprazole tablet increases the stomach residence time and bioavailability, increasing therapeutic efficacy. Formulations F1, F2, F4, F5, F7, and F8 showed good floating, but Formulations F3, and F6 showed moderate floating throughout all 8 formulations. The stability analyses that were done for all the formulations showed that the F7 and F8 formulations had good stability.
Keywords: Pantoprazole, Floating tablet, Hydroxy ethyl cellulose (HEC), Cyclodextrin, In-vitro drug release studies.
Reformulation and Scientific Evaluation of CUSOCO: A Traditional Toothpaste Formula from Classical Tamil Literature towards treatment of Halitosis
Authors: Chandran M. , Priyanka R. , Kavipriya D. , Ramya S. , Jayakumararaj R. , Loganathan T. , Pandiarajan G. , Kaliraj P. , Grace Lydial Pushpalatha G , Abraham GC. , Dhakar Ram Chand 
Published: October 2022

In order to achieve the multi-claim products required for dental-health-care and hygiene, it is indispensable for the formulator to use a wide range of ingredients however, with the advent of technology the chemically synthesised products are not of demand in the market as they have side effects and are considered to unsafe for human use. This places quite a number of demands on the use of PBNPs in the development process. Use of PBNPs innovations in the areas of pharmaceutical technology have contributed significantly to the formulation of dental-health-care products with superior efficacy as well as other attributes that may contribute to clinical response and patient acceptability. Improved clinical efficacy and tolerability, along with conditioning signals, should encourage patient compliance with oral hygiene. Cuminum cyminum seeds are being habitually used in traditional cuisines of different cultures. In India, it is used in both whole and ground form as a traditional ingredient to make dishes without perceptive medicinal knowledge/ properties behind. In Kerala, decoction of cumin seeds is used for drinking (Jeera water). In Tamilnadu, cumin seeds are the key ingredient of Rasam. Fruit of Solanum lycopersicum is one of the important savoury vegetable used in traditional Indian cuisines. The oil of Cocos nucifera fruits are used in cooking in Kerala and TamilNadu. In the present study, composition (paste) prepared by mixing of 2 drops of S. lycopersicum fruit juice, 2 drops of C. nucifera and 1g of C. cyminum seed powder were tested on 100 subjects with felt bad breath. Results of the present study was found to be effective in controlling bad breath (odour) in 74 subjects after the treatment (period of clinical trial) except 09 of 83 subjects who were diabetic.
Keywords: Oral hygiene; bad breath; halitosis; Cuminum cyminum; Solanum lycopersicum; Cocos nucifera; CUSOCO; dental-health-care
Phenytoin Induced Cerebral Atrophy: A Case Report
Authors: Linggi Celeste , Mathews Anit , Mopidevi Rasi , Nyamagoud Sanat Kumar B. , D.S. Usha 
Published: October 2022

Phenytoin is the most common drug prescribed in patient diagnosed with seizure. Cerebral atrophy is an observed complication in phenytoin exposed patients. The side effects related to phenytoin administration include sedation, dizziness, swaying, rash and gum hypertrophy. In the following case report a 50-year-old male patient with complaints of poor response to oral commands, slurred speech, limited upper limb movements and neck rigidity, the patient is a known epileptic since 1 year on prescription and is alcoholic. Upon CT scan of brain, the impression was mild diffuse cerebellar atrophy probably due to long term phenytoin use. Hence frequent phenytoin level monitoring in patient prescribed with the same is mandatory.
Keywords: phenytoin, epilepsy, cerebral atrophy