bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of treatment interruptions and outcomes in cancer patients undergoing radiotherapy during the first wave of COVID-19 pandemic in a tertiary care institute
Authors: Barik Sandip Kumar , Singh Arvind Kumar , Mishra Minakshi , Amritt Adhar , Sahu Dinesh Prasad , Das Majumdar Saroj Kumar , Parida Dillip Kumar 
Published: July 2022

AbstractIntroductionCOVID-19 patients with cancer had poorer outcomes due to immunosuppression during cancer care, poor general condition, and other comorbidities. The study was conducted to present the real-world analysis of the effect of treatment interruptions on the outcomes of patients treated with radiation therapy during the first wave of the COVID-19 pandemic in a tertiary care institute in India.Materials and methodsThe study is a retrospective observational cohort study on cancer patients undergoing radiation therapy from March 2020 to January 2021. The study’s primary outcome was to analyze the effect of treatment interruptions on the outcomes of patients treated with radiation therapy during the first wave of COVID-19 pandemic.ResultsBetween March 2020 to January 2021, 218 eligible patients undergoing radiation therapy were found for the study. Among the 218 patients, 25 patients (11.47%) were found positive for COVID-19, while 193 patients (88.53%) were negative for COVID-19. Among COVID-19-positive patients, ten patients had < 3 weeks of treatment interruption, while 15 patients had > 3 weeks of treatment interruptions. After recovering from COVID-19, treatment was resumed and completed for 15 (60.00%) of the COVID-19-positive patients. In comparison, 13 patients (52.00%) were lost to follow-up. Three of the COVID-19-positive patients died. The disease was clinically controlled in 12 (48.00%) of the COVID-19-positive patients, and the patients reported locoregional disease progression in 10 (40.00%). Among the 193 COVID-19-negative patients, 32 patients (16.58%) had treatment interruption. Twelve patients (37.50%) had treatment interruptions for less than 1 week. There was a significant difference in the delay of radiation treatment delivery by 2 weeks (11 fractions) in COVID-19-positive patients compared to only two fractions delay in COVID-19-negative patients.ConclusionCOVID-19 impacted the treatment outcomes in both COVID-19-positive and COVID-19-negative cohorts of patients. There was a longer duration of treatment interruptions in the COVID-19-positive patients, leading to fewer patients completing the radiation treatment and thereby increased locoregional disease progression. There was a significant difference in the delay in treatment between the two groups.
A Sri Lankan child with hypersplenism secondary to pre-hepatic portal hypertension, successfully managed with partial splenic artery embolization: a case report and review of the literature
Authors: Arunath Visvalingam , Liyanarachchi Manoj Sanjeewa , Gajealan Sundarraajah , Weerasekara Kumudu 
Published: July 2022

AbstractBackgroundHypersplenism, one of the major complications of portal hypertension, is traditionally treated by splenectomy. However, partial splenic artery embolization is an evolving minimally invasive intervention to treat these patients effectively.Case presentationA 13-year-old girl was referred for further evaluation of isolated splenomegaly with pancytopenia. She did not have bleeding manifestations or features of anemia. She never had hematemesis or melena. On examination, she was pale. Abdominal examination revealed massive splenomegaly of 10 cm below the costal margin without hepatomegaly. Rest of the examination was unremarkable. Her investigations revealed a white cell count of 1700/mm3(neutrophils 9.8% and lymphocytes 88.7%), hemoglobin 9.5 g/dL and platelet count 42,000/mm3. Blood picture showed pancytopenia without abnormal cells. Her reticulocyte count was 1.9%. Complete liver profile was normal. Abdominal ultrasonography revealed massive splenomegaly with the oblique length of 17 cm and normal echogenic liver with normal size. Cavernous transformation of portal vein with portal hypertension was evident. Mesenteric angiogram showed portal vein thrombosis and markedly tortuous splenic artery. Anti-nuclear antibodies and double-stranded DNA were negative. Ham test and urine for hemosiderin were negative. Clauss fibrinogen assay was normal. Hemoglobin high performance liquid chromatography for hemoglobin subtypes was normal. Anti-phospholipid antibodies were negative. JAK2 V617F mutation was not identified. Diagnosis of pre hepatic portal hypertension was made. Her upper gastrointestinal endoscopy was normal. Partial splenic artery coil embolization was done by interventional radiology team. Vaccines against capsulated organisms were given. Post-procedure contrast abdominal computed tomography revealed infarction of approximately 70% of the spleen and blood counts were improved. Index case is in the follow up for 3 years. She is on penicillin prophylaxis with regular blood count and annual upper gastrointestinal endoscopy monitoring.ConclusionsMinimally invasive interventions such as partial splenic artery embolization should be considered in managing the patients with hypersplenism secondary to portal hypertension.
Single-cell transcriptomic signatures and gene regulatory networks modulated by Wls in mammalian midline facial formation and clefts
Authors: Gu Ran , Zhang Shuwen , Saha Subbroto Kumar , Ji Yu , Reynolds Kurt , McMahon Moira , Sun Bo , Islam Mohammad , Trainor Paul A. , Chen YiPing , Xu Ying , Chai Yang , Burkart-Waco Diana , Zhou Chengji J. 
Published: July 2022

ABSTRACT
Formation of highly unique and complex facial structures is controlled by genetic programs that are responsible for the precise coordination of three-dimensional tissue morphogenesis. However, the underlying mechanisms governing these processes remain poorly understood. We combined mouse genetic and genomic approaches to define the mechanisms underlying normal and defective midfacial morphogenesis. Conditional inactivation of the Wnt secretion protein Wls in Pax3-expressing lineage cells disrupted frontonasal primordial patterning, cell survival and directional outgrowth, resulting in altered facial structures, including midfacial hypoplasia and midline facial clefts. Single-cell RNA sequencing revealed unique transcriptomic atlases of mesenchymal subpopulations in the midfacial primordia, which are disrupted in the conditional Wls mutants. Differentially expressed genes and cis-regulatory sequence analyses uncovered that Wls modulates and integrates a core gene regulatory network, consisting of key midfacial regulatory transcription factors (including Msx1, Pax3 and Pax7) and their downstream targets (including Wnt, Shh, Tgfβ and retinoic acid signaling components), in a mesenchymal subpopulation of the medial nasal prominences that is responsible for midline facial formation and fusion. These results reveal fundamental mechanisms underlying mammalian midfacial morphogenesis and related defects at single-cell resolution.
Bisphenol-A impairs synaptic formation and function by RGS4-mediated regulation of BDNF signaling in the cerebral cortex
Authors: Hyun Sung-Ae , Ko Moon Yi , Jang Sumi , Lee Byoung-Seok , Rho Jaerang , Kim Kee K. , Kim Woo-Yang , Ka Minhan 
Published: July 2022

ABSTRACT
Bisphenol-A (BPA) is a representative endocrine disruptor, widely used in a variety of products including plastics, medical equipment and receipts. Hence, most people are exposed to BPA via the skin, digestive system or inhalation in everyday life. Furthermore, BPA crosses the blood–brain barrier and is linked to multiple neurological dysfunctions found in neurodegenerative and neuropsychological disorders. However, the mechanisms underlying BPA-associated neurological dysfunctions remain poorly understood. Here, we report that BPA exposure alters synapse morphology and function in the cerebral cortex. Cortical pyramidal neurons treated with BPA showed reduced size and number of dendrites and spines. The density of excitatory synapses was also decreased by BPA treatment. More importantly, we found that BPA disrupted normal synaptic transmission and cognitive behavior. RGS4 and its downstream BDNF/NTRK2 pathway appeared to mediate the effect of BPA on synaptic and neurological function. Our findings provide molecular mechanistic insights into anatomical and physiological neurotoxic consequences related to a potent endocrine modifier.
Synthesis of a Kinetically Stabilized 2,2-Dihydrosilene
Authors: Garcia Julius Adrie , Yasui Yuji , Yukimoto Mariko , Mizuhata Yoshiyuki , Tokitoh Norihiro 
Published: July 2022

Abstract
An overcrowded 2,2-dihydrosilene bearing 2,4,6-tris[bis(trimethylsilyl)methyl]phenyl (Tbt) and 2,6-diisopropylphenyl (Dip) groups was synthesized as a stable compound both in the solid state and in solution for a long period of time. The newly generated 2,2-dihydrosilene was obtained by exhaustive reduction of the corresponding dibromosilane, Tbt(Dip)SiBr2, with an excess amount of lithium naphthalenide at −78 °C followed by addition of CH2Cl2. The formation of 1 was confirmed by multinuclear NMR studies and extensive theoretical calculations.
Personal protective equipment used by obstetricians and obstetric nurses during the COVID-19 pandemic in Mansoura, Egypt
Authors: Khashaba Eman , El-Gilany Abdel-Hady , Shalaby Hend , El-Kurdy Rania 
Published: July 2022

Background: This study was done to describe the pattern of personal protective equipment (PPE) use, associated factors, and adverse events among obstetricians and obstetric nurses in obstetrics & gynecology departments. Methods: A cross sectional study was conducted in Obstetrics & Gynecology departments in three hospitals (physician & nurses n=252) using an online Google form including demographic and occupational health data, type of available personal protective equipment during usual care, CS and emergency labor, infection control measures and hazards of full PPE use. Results Full PPE use was 37.7% during CS and 34.9% during emergency labor. The significant predictors of wearing full PPE during CS were daily work hours > 8 hours and receiving formal training about PPE use. During CS & emergency labor most of HCws used sterile gloves and sterile fluid resistant gowns and surgical mask.to less extent used face shields or tight fitting googles and one tenth (11.8%) only used N95. The most common health effects of full PPE use was sense of heat (79.5%). Conclusion: During the COVID-19 pandemic more vigorous respiratory (N95 mask) and eye protection is required during aerosol-generating procedures. Formal training is an evident predictor for full PPE use.
“Exclusivity” and quantifier float in bakari
Authors: Otsuka Takashi , Shirakawa Ryo , Hashimoto Osamu , Numata Yoshiko 
Published: July 2022

This paper presents a descriptive study that analyzes the semantic meaning of toritate focus particle bakari. It has been pointed out that while bakari expresses exclusivity, it seemingly possesses the characteristic of allowing non-applicable cases. This phenomenon may be examined when one argues against the position that bakari expresses exclusivity. Contrary to this view, the current study shows that when bakari co-occurs with floating quantifiers, non-applicable cases cannot be included in the quantity of the item indicated by the quantifier in question, thereby arguing that the meaning of bakari should be taken as exclusivity. Based on the previous studies, we clarify the following two points. First, when bakari is used, apart from a pre-established objective set reflecting the world, a subjective set rooted in the speaker's experience is established, and when a floating quantifier co-occurs with bakari, the quantifier in question expresses the quantity of the subjective set. Second, toritate focus particle bakari represents exclusivity, and the non-applicable cases can exist only outside of the set that bakari is concerned with.
Learning by engaging
Authors: Gómez-Puig Marta , Stoyanova Alexandrina 
Published: July 2022

The Universitat de Barcelona research group in teaching innovation GIDTAAVE organized the 2nd International Conference in Experiences in Active Learning in Higher Education, which was held online on 5 November, 2021. The aim of the conference was to provide a forum for high-quality research in teaching innovation in higher education, focusing on active learning methodologies. The event provided an excellent opportunity for lecturers from different universities to discuss their work in a relaxed atmosphere and to develop long-term collaborative relationships. Specifically, twelve papers were presented by authors from different Spanish Universities (Universidad de Salamanca, Universidad de Cantabria, Universidad de Navarra, Universidad Juan Carlos I and Universidad Carlos III, to name a few), who had the opportunity to share their experiences with other colleagues. Each session was followed by fruitful discussions among the participants. The keynote speech of the conference was given by Steven Proud, who is currently the Director of Undergraduate Studies and a Reader in Economics Education in the School of Economics at the University of Bristol. Steven Proud gave a very interesting talk entitled “What are the barriers to active learning in economics?”.
Work from home: bane or blessing? Implications for corporate real estate strategies
Authors: Höcker Martin Christian , Bachtal Yassien , Pfnür Andreas 
Published: July 2022

AbstractTechnological progress and developments in the economy and society are constantly changing the way we work. The ongoing COVID-19 pandemic is accelerating the move towards multilocal working: knowledge workers worldwide have been forced to gain experience of working from home. Based on this experience, they are now in a position to weigh up different places of work and articulate desires for the distribution of working time between home workplace, third places and office.Previous studies have shown that working from home can have positive effects for corporates in the form of productivity increases. However, it has so far remained open which employees exactly are successful at different workplaces. The aim of the study is to identify clusters with their own workplace distribution based on personal, work-related and real estate characteristics, and to investigate whether the desire for specific workplace distribution promises success.Identification of the subgroups is done by conducting a hierarchical cluster analysis that includes previously identified personal, work-related and real estate characteristics. The evaluation and interpretation of the cluster solution is based on the desired workplace distribution and identified work success variables. Data from a survey of 2000 German and US knowledge workers is taken into account.The results of the survey suggest that knowledge workers in Germany and the US have developed a good sense of the workplace in which they can work successfully. At the same time, the decision-makers in the corporates have to decide carefully who should work at which workplace with a view to the corporate’s success. It is also clear that as work becomes more multilocational, real estate resources must play an important role in creating a corporate culture and identity.
Relational Data Model on The University Website with Search Engine Optimization
Authors: Alifi Muhammad Riza , Hayati Hashri , Wonoseto Muhammad Galih 
Published: July 2022

The visibility of a university’s website on the search engine becomes an essential factor to reach a wider audience. One way to improve the visibility of a website is through Search Engine Optimization (SEO). University’s website development with SEO is inseparable from the data model because SEO supporting factors are parts of the consideration in the components and structure of the data model. This study aims to build a data model for a university website accompanied by SEO. The relational data model is used in this study based on the performance and maturity in defining schema-based design. This study was conducted through four sequential stages: literature review, planning, implementation, and evaluation. The resulting relational data model is one that has accommodated four supporting factors for SEO, namely Meta description, Meta keywords, URL structure, and image description. This study has succeeded in building a relational data model at the abstraction level of conceptual and logical. In the conceptual data model, one entity and 11 attributes are formed. The logical data model was implemented in independent work environments using RelaX and operational requirements can be fulfilled by representing each table or relationship in the schema using relational algebra.
Differential Effects of the G-Protein-Coupled Estrogen Receptor (GPER) on Rat Embryonic (E18) Hippocampal and Cortical Neurons
Authors: Pemberton Kyle , Rosato Martina , Dedert Cass , DeLeon Chelsea , Arnatt Christopher , Xu Fenglian 
Published: July 2022

AbstractEstrogen plays fundamental roles in nervous system development and function. Traditional studies examining the effect of estrogen in the brain have focused on the nuclear estrogen receptors (ERs), ERα and ERβ. Studies related to the extranuclear, membrane-bound G-protein-coupled ER (GPER/GPR30) have revealed a neuroprotective role for GPER in mature neurons. In this study, we investigated the differential effects of GPER activation in primary rat embryonic day 18 (E18) hippocampal and cortical neurons. Microscopy imaging, multielectrode array (MEA), and Ca2+imaging experiments revealed that GPER activation with selective agonist, G-1, and nonselective agonist, 17β-estradiol (E2), increased neural growth, neural firing activity, and intracellular Ca2+more profoundly in hippocampal neurons than in cortical neurons. The GPER-mediated Ca2+rise in hippocampal neurons involves internal Ca2+store release via activation of phospholipase C (PLC) and extracellular entry via Ca2+channels. Immunocytochemistry results revealed no observable difference in GPER expression/localization in neurons, yet real-time qPCR (RT-qPCR) and Western blotting showed a higher GPER expression in the cortex than hippocampus, implying that GPER expression level may not fully account for its robust physiological effects in hippocampal neurons. We used RNA sequencing data to identify distinctly enriched pathways and significantly expressed genes in response to G-1 or E2 in cultured rat E18 hippocampal and cortical neurons. In summary, the identification of differential effects of GPER activation on hippocampal and cortical neurons in the brain and the determination of key genes and molecular pathways are instrumental toward an understanding of estrogen’s action in early neuronal development.
Pituitary function and the response to GH therapy in patients with Langerhans cell histiocytosis: analysis of the KIMS database
Authors: Touraine Philippe , Sagna Yempabou , Mattsson Anders F , Burman Pia , Van Beek André P , Carlsson Martin Ove , Aydin Ferah , Feldt-Rasmussen Ulla , Camacho-Hübner Cecilia 
Published: July 2022

Objective
To analyze the effectiveness and safety of growth hormone (GH) replacement treatment in adult patients with Langerhans cell histiocytosis (LCH) and GH deficiency (GHD) enrolled in KIMS (Pfizer International Metabolic Database).

Patients and methods
Patients with LCH and GHD were studied at baseline and some of them after 1 year of GH treatment. The effectiveness of GH is presented as change after 1 year of treatment (mean, 95% CI). The LCH population was compared to two other groups of patients enrolled in KIMS, granulomatous and lymphocytic hypophysitis.

Results
At baseline, 81 adults with LCH (27 with childhood onset, 56% females), mean age at GHD onset of 29 (15) years were studied. Diabetes insipidus was diagnosed in 86% of patients. Analysis of 1 year of GH treatment was possible in 37 patients. One-year cross-sectional values for the GH dose were 0.39 (s.d.± 0.21) mg and −0.5 (−1.2 to 0.2) for insulin-like growth factor-1 s.d. Total cholesterol decreased 0.9 (−1.5 to −0.3 (mmol/L); P < 0.05); AGHDA-QoL-score (n = 20) was improved by 2.8 points (−5.6 to 0.0; P < 0.05), while mean BMI increased 0.6 ± 3 kg/m2 (95% CI: −0.2 to 1.4). All these effects did not differ from the two other groups after adjusting for age, gender, and baseline values. In 20 of 77 patients included in the safety analysis, 36 serious adverse events were reported during 435 patient-years (82.8/1000); no new safety signals were reported.

Conclusion
After 1 year of GH treatment in patients with LCH, metabolic variables and quality of life improved, with no new safety signals.
“ELSA SPEAK” IN AN ONLINE PRONUNCIATION CLASS: STUDENTS’ VOICES
Authors: Yosintha Rolisda , Rekha Agnira 
Published: July 2022

ABSTRACTDeveloping productive skills such as pronunciation requires more than just comprehension. Students should have ample opportunities to practice their knowledge. With the strike of Covid-19 that has abruptly shifted learning from offline to an online setting, lecturers have tried to employ technologies such as Elsa Speak in teaching pronunciation online. With the rising popularity of this application, there should be a study investigating how the students perceive Elsa Speak in online pronunciation learning. To do so, this present study employed a mixed-method approach to know the attitudes of 112 English Department students toward Elsa Speak used in their online pronunciation class. Through an analysis of data collected from questionnaires and interviews, the study found that most participants had a positive attitude toward Elsa Speak concerning its use in their online pronunciation class. Even though there were some negative comments from the participants, the benefits outweighed the downside. To make the integration of Elsa Speak into online pronunciation learning more accommodating to students’ needs, lecturers could take some pedagogical measures, such as supplementing the materials provided by Elsa Speak with those from other resources, increasing their involvement during the learning process, and promoting collaborative activities. ABSTRAKMengembangkan keterampilan produktif seperti pengucapan membutuhkan lebih dari sekedar pemahaman. Siswa harus diberi banyak kesempatan untuk mempraktikkan pengetahuan mereka. Dengan adanya wabah Covid-19 yang mengubah sistem pembelajaran dari luring ke daring, dosen menggunakan teknologi seperti Elsa Speak dalam mengajar mata kuliah pengucapan secara daring. Dengan meningkatnya popularitas dari aplikasi ini, harus ada penelitian yang menyelidiki bagaimana persepsi siswa tentang Elsa Speak dalam pembelajaran pengucapan secara daring. Penelitian ini menggunakan pendekatan metode campuran untuk mengetahui sikap 112 mahasiswa Jurusan Bahasa Inggris terhadap Elsa Speak yang digunakan di kelas pengucapan daring mereka. Melalui analisis data yang dikumpulkan dari kuesioner dan wawancara, peneliti menemukan bahwa sebagian besar mahasiswa memiliki sikap positif terhadap Elsa Speak terkait penggunaannya di kelas mereka. Meskipun terdapat beberapa komentar negatif dari partisipan, manfaat Elsa Speak lebih besar daripada kerugian yang ditimbulkan. Supaya integrasi Elsa Speak ke dalam pembelajaran pengucapan secara daring lebih mengakomodasi kebutuhan mahasiswa, dosen dapat mengambil beberapa langkah pedagogis, seperti menggunakan materi tambahan untuk memberi variasi terhadap materi yang disediakan oleh Elsa Speak, meningkatkan keterlibatan dosen selama proses pembelajaran, dan mengimplementasikan kegiatan pembelajaran yang kolaboratif.