bluuebunny/crossref_metadata_2025_split huggingface dataset:
Later energy intake relative to mathematically modeled circadian time is associated with higher percentage body fat
Authors: McHill Andrew W. , Brown Lindsey S. , Phillips Andrew J. K. , Barger Laura K. , Garaulet Marta , Scheer Frank A. J. L. , Klerman Elizabeth B. 
Published: June 2022

AbstractObjectiveLater circadian timing of energy intake is associated with higher body fat percentage. Current methods for obtaining accurate circadian timing are labor‐ and cost‐intensive, limiting practical application of this relationship. This study investigated whether the timing of energy intake relative to a mathematically modeled circadian time, derived from easily collected ambulatory data, would differ between participants with a lean or overweight/obesity body fat percentage.MethodsParticipants (N = 87) wore a light‐ and activity‐measuring device (actigraph) throughout a cross‐sectional 30‐day study. For 7 consecutive days within these 30 days, participants used a time‐stamped‐picture phone application to record energy intake. Body fat percentage was recorded. Circadian time was defined using melatonin onset from in‐laboratory collected repeat saliva sampling or using light and activity or activity data alone entered into a mathematical model.ResultsParticipants with overweight/obesity body fat percentages ate 50% of their daily calories significantly closer to model‐predicted melatonin onset from light and activity data (0.61 hours closer) or activity data alone (0.86 hours closer; both log‐rank p < 0.05).ConclusionsUse of mathematically modeled circadian timing resulted in similar relationships between the timing of energy intake and body composition as that observed using in‐laboratory collected metrics. These findings may facilitate use of circadian timing in time‐based interventions.
Individuals with obesity who survive SARS‐CoV‐2 infection have preserved antigen‐specific T cell frequencies
Authors: Wrigley Kelly Neil E. , Kenny Grace , Cassidy Féaron C. , Garcia‐Leon Alejandro A. , De Barra Conor , Mallon Patrick W. G. , Hogan Andrew E. , O'Shea Donal 
Published: June 2022

AbstractObjectiveObesity is a major risk factor for severe disease in COVID‐19, with increased hospitalization, intensive care unit admission, and mortality. This increased impact of COVID‐19 in people with obesity (PWO) is likely driven, in part, by the well‐described obesity‐induced immune dysregulation. Obesity has also been associated with impaired immune memory in many settings, including weakened responses to hepatitis B, tetanus, rabies, and influenza vaccination. Recently, it was reported that PWO who have COVID‐19 have reduced IgG antibody titers with defective neutralizing capabilities. However, it remains unknown whether PWO generate durable T cell immunity to SARS‐CoV‐2.MethodsThis study investigated SARS‐CoV‐2‐specific T cell responses in a cohort of 40 patients (n = 20 PWO and n = 20 matched control individuals) who had recovered from COVID‐19. T cell (CD4+, CD8+) cytokine responses (IFNγ, TNFα) to SARS‐CoV‐2 peptide pools (spike, membrane) were determined using multicolor flow cytometry.ResultsCirculating T cells specific for SARS‐CoV‐2 were readily detected in the total cohort. PWO displayed comparable levels of SARS‐CoV‐2 spike‐ and membrane‐specific T cells, with both T cell subsets responding.ConclusionsThese data indicate that PWO who survive COVID‐19 generate robust and durable SARS‐CoV‐2‐specific T cell immunity that is equivalent to that seen in those without obesity.
An eight‐membered cyclosiloxane conjugated microporous polymer performed a rapid and sensitive fluorescence detection of 2,4‐dinitrophenol
Authors: Geng Tongmou , Wang Fengqiang , Fang Xuechun , Xia Hongyu 
Published: June 2022

AbstractA nitrogen‐rich porous inorganic–organic hybrid polymer, TMPS, was successfully synthesized by Friedel–Crafts arylation with anhydrous aluminum trichloride as a catalyst, which has good sensitivity to nitro‐aromatic compounds. The material was systematically characterized by using FT‐IR, solid‐state 13C NMR, elemental analysis, powder X‐ray diffraction, solid‐state UV–Vis, and so forth. The thermogravimetric analysis experiments confirmed that TMPS has very good thermal stability. Its Brunauer Emmett Teller specific surface area measured by nitrogen adsorption desorption experiment is 115 m2 g−1. Due to its excellent conjugated structure and nitrogen‐rich features, TMPS exhibits a very high sensitivity and selectivity to 2,4‐dinnitrophenol. Based on the data obtained from the fluorescence detection experiment, the KSV and limit of detection are 1.84 × 104 L mol−1 and 1.63 × 10−11 mol L−1, respectively. Therefore, TMPS can act as a fast and sensitive fluorescent sensor to detect DNP.
Tribological performance evaluation of slag waste filled phenolic composites for automotive braking applications
Authors: Rajan R. , Tyagi Yogesh K. , Pruncu Catalin I. , Kulshreshtha Shweta , Ranakoti Lalit , Singh Tej 
Published: June 2022

AbstractSlag waste‐filled phenolic resin‐based automotive brake friction composites were formulated, fabricated, followed by mechanical, physical characterization, and tribo‐evaluation. According to economic commission for Europe regulation, the tribological performance of the composites was evaluated on a Krauss friction‐testing machine. The increase in slag waste content led to increased physical properties such as density, porosity, ash contents, and compressibility, whereas hardness, acetone extraction, and shear strength increased with increased phenolic resin content. The fade and friction performance has been observed to be highly dependent on the slag waste content, that is, both followed a consistent decrease with the increase in the phenolic resin content, whereas the frictional fluctuations have been observed to decrease with the increase in slag waste content. In particular, the composites containing 65 wt% slag waste and 5 wt% phenolic resin showed the highest friction coefficient (0.406), lowest fade (20.44%) and frictional fluctuation (0.209), but the wear (10.80 g) and disc temperature rise (618°C) remains highest. Composite with the lowest slag waste content of 50 wt% combined with the highest phenolic resin of 20 wt% showed higher recovery performance (120.63%), lowest wear (4.45 g) and disc temperature rise (536°C), but exhibits lowest friction coefficient (0.315) and friction stability (0.79) along with highest friction variability (0.60) and fluctuations (0.238). Friction and wear data analysis revealed the predominance of the fade factor for friction performance while the fade factor and disc temperature‐induced results significantly influence the wear performance. The worn surface micrograph showed higher phenolic resin‐filled composites form smooth contact plateaus that successfully reduced wear.
Viscosity‐curing time behavior, viscoelastic properties, and phase separation of graphene oxide/epoxy asphalt composites
Authors: Zhao Ruikang , Jing Fan , Li Chenxuan , Wang Rui , Xi Zhonghua , Cai Jun , Wang Qingjun , Xie Hongfeng 
Published: June 2022

AbstractGraphene oxide (GO) with 0.2, 0.5, and 1.0 wt% loading was used to modify warm‐mix epoxy asphalt binders (WEABs). The thermal stability, structure of GO, rotational viscosity‐curing time performance, dynamic moduli, glass transitions, damping ability, mechanical performance, and phase‐separated morphology of GO/epoxy asphalt composites were investigated in the laboratory. GO significantly enhanced the thermal stability of the pure WEAB. X‐ray scattering analysis revealed that GO layers were delaminated in the epoxy asphalt binder. GO accelerated the cure reaction of the pure WEAB and thus resulted in higher rotational viscosity of GO/epoxy asphalt composites. Furthermore, the viscosity of the modified WEABs slightly increased in the GO content. GO increased the dynamic moduli and Tgs of both epoxy and asphalt for the pure WEAB. However, the damping ability of GO/epoxy asphalt composites was similar to that of the pure WEAB. Confocal microscopy observations revealed that GO was dispersed in both asphalt and epoxy phases of the phase‐separated WEAB. The asphalt domains in the continuous epoxy phase became more spherical and uniform with the existence of GO. Moreover, the dispersion of epoxy in the discontinuous asphalt phase became more evident. The mechanical properties of the pure WEAB were greatly improved with the addition of GO. The tensile toughness and strength of the pure WEAB increased by 31% and 33%, respectively, with the addition of 0.2 wt% GO.
Treatment of phenylalanine and tyrosine in phosphate‐buffered saline by plasma‐supplied oxygen atoms: Chemical characterization and bactericidal effects
Authors: Jirásek Vít , Tarabová Barbora , Lukeš Petr 
Published: June 2022

AbstractPlasma‐treated liquid media containing amino acids have been shown to be effective as disinfectants and antitumor agents. The current study presents chemical analyses and bactericidal properties of mixtures formed by the treatment of phenylalanine and tyrosine in phosphate‐buffered saline in He/O2 plasma. A major process observed was the formation of amino acid mono‐ and di‐chloramines accompanied by the oxidation of the amino acid aromatic ring. The chemical activity of treated solutions lasted up to 90 min after plasma treatment. After being acidified to ~pH 3, the treated solutions exhibited a bactericidal effect against Escherichia coli. This effect was associated with the post‐discharge reactions of amino acid dichloramines and the formation of C‐1 nitrile as the final product.
Cold atmospheric plasma does not affect the regenerative potential of the pulp in rats
Authors: Gund Madline P. , Hannig Matthias , Laschke Matthias W. , Lehmann Antje , Schindler Axel , Rupf Stefan 
Published: June 2022

AbstractThe aim of this study was to investigate the effect of cold atmospheric plasma (CAP) treatment combined with adhesive filling therapy on rat dental pulps. Cavities were prepared in the first maxillary molars of 20 Sprague Dawley rats. The first molar and the unprepared second molar of one randomly selected maxillary quadrant were treated with CAP. The prepared cavities were filled with composite. After 24 h and 28 days, 10 rats each were killed. Teeth were demineralized and embedded in paraffin and histological sections were stained with hematoxylin–eosin and chloracetatesterase. None of the pulps displayed necrosis. Plasma treatment caused no additional alteration to the dental pulp in combination with adhesive filling therapy. These findings indicate that plasma treatment is compatible with the regenerative potential of the pulp.
An “Off‐On” Fluorescence Sensing Platform Based on Aminated Carbon Quantum Dots and Silver Nanoparticles for Sensitive and Selective Quantifying Dopamine in Serum
Authors: Guo Wenwen , Wang Qiuyue , Zhan Xin , Zhang Bin , Wu Yiwei 
Published: June 2022

AbstractAminated carbon quantum dots (N‐CQDs) and p‐amino thiophenol capped silver nanoparticles (N‐AgNPs) are mixed physically to fabricate an optical nanocomposite of N‐CQDs/N‐AgNPs. A highly selective and sensitive “off‐on” fluorescence sensing strategy for monitoring dopamine in human serum is established based on the nanocomposite. Through an electrostatic interaction between N‐CQDs and N‐AgNPs, N‐CQDs/N‐AgNPs nanocomposite is assembled. The initial fluorescence of N‐CQDs is effectively “off” by N‐AgNPs owing to the inner filter effect. However, with the addition of dopamine, stronger π–π stacking or hydrogen bonding ability of super‐adhesive polydopamine produced from dopamine at pH 8 to water‐soluble N‐CQDs can make N‐CQDs to dissociate from N‐CQDs/N‐AgNPs nanocomposite with fluorescence “on” as a result of the termination of inner filter effect. Meanwhile, the dissociation of N‐CQDs/N‐AgNPs nanocomposite and the existence of oxygen in the air may trigger the formation of Ag2S. Under the optimal conditions, the activated fluorescence intensity at 477 nm is linearly proportional to dopamine in the range of 0.33–65 × 10−9 m with a detection limit of 0.1 × 10−9 m and 1.2% RSD. The established sensing platform has successfully detected dopamine in serum with satisfactory results and may be an alternative powerful technique for further clinical diagnosis of dopamine‐related diseases.
Initial Temperature Effects on the Combustion Characteristics of Al
Authors: Liu Hui , Liu Jianzhong , Yuan Jifei , Chen Xiaolin , Zhao Yu , Xie Wuxi 
Published: June 2022

AbstractThe combustion of aluminium in propellants plays an important role in the energy release of propellants, and investigations of the combustion mechanism of aluminium can help to further improve the energy release characteristics of propellants. The changes in reaction temperature and product content over time during the reaction of Al(l)/O2 and Al(l)/AP systems at different initial temperatures were calculated using the Closed Homogeneous Batch Reactor in CHEMKIN‐PRO, and a sensitivity analysis was performed for the Al(l)/AP system. The results showed that with increases in the initial temperature, the heat storage time and combustion time of the Al(l)/O2 system were shortened and the equilibrium temperature increased, which was also true for the Al(l)/AP system. Moreover, the increase of initial temperature was favourable to the decomposition of O2 and the formation of AlO in Al(l)/O2 system but had little effect on the Al/AP system. The main reaction path of the Al(l)/AP system changed with increases of initial temperature, although
,
,
, and
are common elementary reactions with high temperature sensitivity and thus play a decisive role in the change of H2, AlCl, AlO and O contents as well as the changes of the reaction temperature of the system. In this paper, the combustion characteristics of an Al/AP system were investigated in depth, and the results can provide a theoretical basis for revealing the combustion mechanism and improving the energy release characteristics of aluminium‐based AP‐containing solid propellants.
Does castration status affect docetaxel‐related adverse events? :Identification of risk factors for docetaxel‐related adverse events in metastatic prostate cancer
Authors: Yanagisawa Takafumi , Kimura Takahiro , Hata Kenichi , Narita Shintaro , Hatakeyama Shingo , Enei Yuki , Atsuta Mahito , Mori Keiichiro , Obayashi Koki , Yoshihara Kentaro , Kondo Yosuke , Oguchi Takahiro , Sadakane Ibuki , Habuchi Tomonori , Ohyama Chikara , Shariat Shahrokh F. , Egawa Shin 
Published: June 2022

AbstractBackgroundDocetaxel‐related adverse events (AEs) such as neutropenia and febrile neutropenia (FN) can be life‐threatening. A previous in vivo study raised the hypothesis that the castration status affects the rate of hematologic AEs. We aimed to investigate the impact of castration status on the incidence of docetaxel‐related AE in metastatic prostate cancer (mPCa) patients.MethodsWe retrospectively analyzed the records of 265 mPCa patients treated with docetaxel, comprising 92 patients with metastatic hormone‐sensitive prostate cancer (mHSPC) and 173 patients with metastatic castration‐resistant prostate cancer (mCRPC) between January 2015 and December 2021. Common terminology Criteria for Adverse Events (CTCAE) was applied to evaluate AEs. We analyzed the differential incidences between mHSPC and mCRPC, and risk factors of hematologic and nonhematologic AEs using a logistic regression model.ResultsThe rate of patients who received primary prophylaxis against neutropenia was higher in those with the mHSPC compared with those with the mCRPC (7.5% vs. 33%, p < 0.001). Among the patients without primary prophylaxis, incidence rates of severe neutropenia (CTCAE ≥ Grade3) and FN were 89% and 16% in patients with mCRPC compared to 81% and 18% in those with mHSPC. Logistic regression analysis revealed that age ≥ 75 years and failure to provide primary prophylaxis were independent risk factors of severe neutropenia (odds ratio [OR]: 2.39, 95% confidential interval [CI]: 1.10–5.18 and OR: 15.8, 95% CI: 7.23–34.6, respectively). Eastern Cooperative Oncology Group Performance Status (ECOG‐PS) ≧ 1 was an independent risk factor of FN (OR: 2.26, 95% CI: 1.13–4.54). Castration status (mHSPC vs. mCRPC) was not associated with the risks of severe neutropenia and FN.ConclusionsCastration status did not affect the risk of severe neutropenia or FN in mPCa patients treated with docetaxel regardless of the disease state. Failure to provide primary prophylaxis and advanced patient age are independent risk factors of severe neutropenia; while patients with poor PS are more likely to develop FN. These findings may help guide the clinical decision‐making for proper candidate selection of docetaxel treatment.
Superior Multielectron‐Transferring Energy Storage by π‐d Conjugated Frameworks
Authors: Xia Dong , Sakaushi Ken , Lyalin Andrey , Wada Keisuke , Kumar Sonu , Amores Marco , Maeda Hiroaki , Sasaki Sono , Taketsugu Tetsuya , Nishihara Hiroshi 
Published: June 2022

AbstractReversible multielectron‐transfer materials are of considerable interest because of the potential impact to advance present electrochemical energy storage technology by boosting energy density. To date, a few oxide‐based materials can reach an electron‐transfer number per metal‐cation (eM) larger than 2 upon a (de)intercalation mechanism. However, these materials suffer from degradation due to irreversible rearrangements of the cation–oxygen bonds, and are based on precious metals, for example, Ir and Ru. Hence, a design of the non‐oxide‐based reversible multielectron‐transfer materials with abundant elements can provide a promising alternative. Herein, it is demonstrated that the bis(diimino)copper framework can show eM = 3.5 with cation/anion co‐redox mechanism together with a dual‐ion mechanism. In this study, the role of the cation–anion interactions is unveiled by using an experiment/theory collaboration applied to a series of the model non‐oxide abundant electrode systems based on different metal–nitrogen bonds. These models provide designer multielectron‐transfer due to the tunable π‐d conjugated electronic structures. It is found that the Cu–nitrogen bonds show a unique reversible rearrangement upon Li‐intercalation, and this process responds to acquire a significant reversible multielectron‐transfer. This work provides new insights into the affordable multielectron‐transfer electrodes and uncovers an alternative strategy to advance the electrochemical energy storage reactions.
Optical Cellular Micromotion: A New Paradigm to Measure Tumor Cells Invasion within Gels Mimicking the 3D Tumor Environments
Authors: Guo Zhaobin , Yang Chih‐Tsung , Chien Chia‐Chi , Selth Luke A. , Bagnaninchi Pierre O. , Thierry Benjamin 
Published: June 2022

AbstractMeasuring tumor cell invasiveness through 3D tissues, particularly at the single‐cell level, can provide important mechanistic understanding and assist in identifying therapeutic targets of tumor invasion. However, current experimental approaches, including standard in vitro invasion assays, have limited physiological relevance and offer insufficient insight into the vast heterogeneity in tumor cell migration through tissues. To address these issues, here the concept of optical cellular micromotion is reported on, where digital holographic microscopy is used to map the optical nano‐ to submicrometer thickness fluctuations within single‐cells. These fluctuations are driven by the dynamic movement of subcellular structures including the cytoskeleton and inherently associated with the biological processes involved in cell invasion within tissues. It is experimentally demonstrated that the optical cellular micromotion correlates with tumor cells motility and invasiveness both at the population and single‐cell levels. In addition, the optical cellular micromotion significantly reduced upon treatment with migrastatic drugs that inhibit tumor cell invasion. These results demonstrate that micromotion measurements can rapidly and non‐invasively determine the invasive behavior of single tumor cells within tissues, yielding a new and powerful tool to assess the efficacy of approaches targeting tumor cell invasiveness.
APOE ε4 and exercise interact in a sex‐specific manner to modulate dementia risk factors
Authors: Foley Kate E. , Diemler Cory A. , Hewes Amanda A. , Garceau Dylan T. , Sasner Michael , Howell Gareth R. 
Published: June 2022

AbstractIntroductionApolipoprotein E (APOE) ε4 is the strongest genetic risk factor for Alzheimer's disease and related dementias (ADRDs), affecting many different pathways that lead to cognitive decline. Exercise is one of the most widely proposed prevention and intervention strategies to mitigate risk and symptomology of ADRDs. Importantly, exercise and APOE ε4 affect similar processes in the body and brain. While both APOE ε4 and exercise have been studied extensively, their interactive effects are not well understood.MethodsTo address this, male and female APOE ε3/ε3, APOE ε3/ε4, and APOE ε4/ε4 mice ran voluntarily from wean (1 month) to midlife (12 months). Longitudinal and cross‐sectional phenotyping were performed on the periphery and the brain, assessing markers of risk for dementia such as weight, body composition, circulating cholesterol composition, murine daily activities, energy expenditure, and cortical and hippocampal transcriptional profiling.ResultsData revealed chronic running decreased age‐dependent weight gain, lean and fat mass, and serum low‐density lipoprotein concentration dependent on APOE genotype. Additionally, murine daily activities and energy expenditure were significantly influenced by an interaction between APOE genotype and running in both sexes. Transcriptional profiling of the cortex and hippocampus predicted that APOE genotype and running interact to affect numerous biological processes including vascular integrity, synaptic/neuronal health, cell motility, and mitochondrial metabolism, in a sex‐specific manner.DiscussionThese data in humanized mouse models provide compelling evidence that APOE genotype should be considered for population‐based strategies that incorporate exercise to prevent ADRDs and other APOE‐relevant diseases.
Multicentric T‐cell lymphoma in a 21‐year‐old Tennessee walking horse mare
Authors: García‐Lacy Fernando , Craig Linden , Trigo‐Tavera Francisco José , Schumacher Jim , Rodríguez‐Monterde Alejandro 
Published: June 2022

AbstractWe report a 21‐year‐old Tennessee walking horse mare afflicted with a multicentric T‐cell lymphoma. A T‐cell‐rich, B‐cell lymphoma had been removed from the mare's left upper eyelid 4 years earlier. The owner reported that the mare had a poor appetite, difficulty swallowing and difficulty breathing while eating. Initial physical examination revealed no abnormalities. Complete blood count and serum biochemical analyses revealed lymphopenia, anaemia and elevated serum globulins. A mass arising from the base of the tongue was found and determined to be a T‐cell lymphoma by histologic and immunohistochemical examination. The mare was anorexic during hospitalisation, showed signs of kidney failure, suffered severe weight loss and was consequently euthanased. During postmortem examination, a second mass, confirmed by immunohistochemical examination to be also a T‐cell lymphoma, was found arising from the abdominal surface of the diaphragm. Early diagnosis of T‐cell lymphoma is difficult, because affected horses display a wide variety of clinical signs.