bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding and scientific progress: lessons from epistemology
Authors: Emmerson Nicholas 
Published: February 2022

AbstractContemporary debate surrounding the nature of scientific progress has focused upon the precise role played by justification, with two realist accounts having dominated proceedings. Recently, however, a third realist account has been put forward, one which offers no role for justification at all. According to Finnur Dellsén’s (Stud Hist Philos Sci Part A 56:72–83, 2016) noetic account, science progresses when understanding increases, that is, when scientists grasp how to correctly explain or predict more aspects of the world that they could before. In this paper, we argue that the noetic account is severely undermotivated. Dellsén provides three examples intended to show that understanding can increase absent the justification required for true belief to constitute knowledge. However, we demonstrate that a lack of clarity in each case allows for two contrasting interpretations, neither of which serves its intended purpose. On the first, the agent involved lacks both knowledge and understanding; and, on the second, the agent involved successfully gains both knowledge and understanding. While neither interpretation supports Dellsén’s claim that understanding can be prised apart from knowledge, we argue that, in general, agents in such cases ought to be attributed neither knowledge nor understanding. Given that the separability of knowledge and understanding is a necessary component of the noetic account, we conclude that there is little support for the idea that science progresses through increasing understanding rather than the accumulation of knowledge.
Predictive minds can think: addressing generality and surface compositionality of thought
Authors: Rappe Sofiia 
Published: February 2022

AbstractPredictive processing framework (PP) has found wide applications in cognitive science and philosophy. It is an attractive candidate for a unified account of the mind in which perception, action, and cognition fit together in a single model. However, PP cannot claim this role if it fails to accommodate an essential part of cognition—conceptual thought. Recently, Williams (Synthese 1–27, 2018) argued that PP struggles to address at least two of thought’s core properties—generality and rich compositionality. In this paper, I show that neither necessarily presents a problem for PP. In particular, I argue that because we do not have access to cognitive processes but only to their conscious manifestations, compositionality may be a manifest property of thought, rather than a feature of the thinking process, and result from the interplay of thinking and language. Pace Williams, both of these capacities, constituting parts of a complex and multifarious cognitive system, may be fully based on the architectural principles of PP. Under the assumption that language presents a subsystem separate from conceptual thought, I sketch out one possible way for PP to accommodate both generality and rich compositionality.
Urethral injection of dedifferentiated fat cells ameliorates sphincter damage and voiding dysfunction in a rat model of persistence stress urinary incontinence
Authors: Murata Yasutaka , Obinata Daisuke , Matsumoto Taro , Ikado Yuichiro , Kano Koichiro , Fukuda Noboru , Yamaguchi Kenya , Takahashi Satoru 
Published: February 2022

Abstract
Purpose
Dedifferentiated fat (DFAT) cells are mature adipocyte-derived multipotent cells that can be applicable to cell-based therapy for stress urinary incontinence (SUI). This study developed a persistence SUI model that allows long-term evaluation using a combination of vaginal distention (VD) and bilateral ovariectomy (OVX) in rats. Then, the therapeutic effects of DFAT cell transplantation in the persistence SUI model was examined.

Methods
In total, 48 Sprague–Dawley rats were divided into four groups and underwent VD (VD group), bilateral OVX (OVX group), VD and bilateral OVX (VD + OVX group), or sham operation (Control group). At 2, 4, and 6 weeks after injury, leak point pressure (LPP) and histological changes of the urethral sphincter were evaluated. Next, 14 rats undergoing VD and bilateral OVX were divided into two groups and administered urethral injection of DFAT cells (DFAT group) or fibroblasts (Fibroblast group). At 6 weeks after the injection, LPP and histology of the urethral sphincter were evaluated.

Results
The VD + OVX group retained a decrease in LPP with sphincter muscle atrophy at least until 6 weeks after injury. The LPP and urethral sphincter muscle atrophy in the DFAT group recovered better than those in the fibroblast group.

Conclusions
The persistence SUI model was created by a combination of VD and bilateral OVX in rats. Urethral injection of DFAT cells inhibited sphincter muscle atrophy and improved LPP in the persistence SUI model. These findings suggest that the DFAT cells may be an attractive cell source for cell-based therapy to treat SUI.
An online research approach for a dual perspective analysis of brand associations in art museums
Authors: Ranfagni Silvia , Milanesi Matilde , Guercini Simone 
Published: February 2022

AbstractThe paper develops a research approach that combines digital ethnography with text mining to explore consumers’ perception of a brand and the degree of alignment between brand identity and image. In particular, the paper investigates the alignment between the art museum’s brand identity and the brand image emerging from visitors’ narratives of their experience. The study adopts a mixed methodology based on netnography and text mining techniques. The analysis concerns an art museum’s brand, with the case of the “Opera del Duomo Museum” in Florence. The methodological approach enables a combined investigation of user-generated content in online communities and the company’s online brand communication, contributing to identifying branding actions that can be taken to increase the brand alignment. It also enables the measurement of the degree of alignment between museums and visitors among common brand themes. Specific indicators of alignment are provided. A key point is the replicability of the model in other contexts of analysis in which the content produced by consumers in online contexts are relevant and readily available, such as fashion or food.
Effect of Prostate Artery Embolization on Erectile Function – A Single Center Experience of 167 Patients
Authors: Bhatia Shivank , Acharya Vedant , Jalaeian Hamed , Kumar Jessica , Bryant Evan , Richardson Andrew , Malkova Kseniia , Harward Sardis , Sinha Vishal , Kably Issam , Kava Bruce R. 
Published: February 2022

ABSTRACTBackgroundProstate artery embolization (PAE) is an emerging therapy for lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH).AimThis retrospective study was conducted to assess the effect of prostate artery embolization (PAE) on erectile function in a cohort of patients with LUTS attributable to BPH at 3-months after the procedure.MethodsA retrospective review was performed on 167 patients who underwent PAE. Data collected included Sexual Health Inventory in Men (SHIM) scores at 3, 6, and 12 months post-PAE, in conjunction with the International Prostate Symptom Scores (IPSS), Quality of Life (QoL) scores, and prostate volumes. Primary outcome was erectile function as assessed by SHIM scores at 3 months after PAE. An analysis was performed to identify patients with a ±5-point SHIM change to group them according to this minimum clinically significant difference in erectile function. Adverse events were recorded using the Clavien-Dindo (CD) classification.OutcomesAt 3 months following PAE, median IPSS decreased by 16.0 [IQR, 9.0–22.0] points, median QOL decreased by 4.0 [IQR, 2.0–5.0] points, and median prostate volume decreased by 33 g [IQR, 14–55].ResultsMedian SHIM score was 17.0 [IQR, 12.0–22.0] at baseline, 18.0 [IQR, 14.0–23.0] at 3 months [P = .031], 19.0 [IQR, 14.5–21.5] at 6 months [P = .106] and 20 [IQR, 16.0–24.0] at 12 months [P = .010] following PAE. In patients with no erectile dysfunction (ED) at baseline, 21% (n = 9) reported some degree of decline in erectile function post-PAE. However, 38% (n = 40) of patients who presented with mild-to-moderate ED reported improvement in their erectile function 3 months following PAE. Overall, the changes in baseline SHIM score were relatively small; 82% (n = 137) of patients did not have more than 5 points of change in their SHIM scores at 3 months following PAE.Clinical ImplicationsOur findings suggest PAE has no adverse impact on erectile function for most patients.Strengths & LimitationsThe study was performed at a single center with 1 operator’s experience, and is retrospective with no control group.ConclusionFindings suggest that prostate artery embolization has no adverse effect on erectile function in the majority of patients with LUTS attributable to BPH at 3 months after the procedure.
Full dynamic model of 3-U

P

U translational parallel manipulator for model-based control schemes
Authors: Hassani Ali , Khalilpour S. A. , Bataleblu Abbas , Taghirad Hamid D. 
Published: February 2022

AbstractOptimal mechanical design, model-based control, and robot dynamic calibration mainly rely on the analytical formulation of robot dynamics. In this paper, the kinematics equations of a general 3-UPU translational parallel manipulator (TPM) are derived, and then, by using the principle of the virtual work theorem, the full implicit dynamic model is derived. Furthermore, by making some modifications, the explicit dynamic formulation of the robot is attained, which is the basis of a wide range of advanced model-based controllers. To validate the proposed formulation, a prototype of the 3-UPU TPM is modeled in MSC-ADAMS® software, and the results of the dynamic formulation are validated using this model. The results show the high accuracy of the proposed dynamic formulation presented in this article.
The Health Humanities and Emergency Medical Services (EMS): A Call to Action
Authors: Morse Kiriana A. , Balhara Kamna S. , Irvin Nathan A. , Levy Matthew J. 
Published: February 2022

AbstractIn the context of an on-going global pandemic that has demanded increasingly more of our Emergency Medical Services (EMS) clinicians, the health humanities can function to aid in educational training, promoting resilience and wellness, and allowing opportunity for self-expression to help prevent vicarious trauma.As the social, cultural, and political landscape of the United States continues to require an expanded scope of practice from our EMS clinicians, it is critical that the health humanities are implemented as not only part of EMS training, but also as part of continued practice in order to ensure the highest quality patient-centered care while protecting the longevity and resilience of EMS clinicians.
Climatology of the Vertical Profiles of Polarimetric Radar Variables and Retrieved Microphysical Parameters in Continental/Tropical MCSs and Landfalling Hurricanes
Authors: Hu Jiaxi , Ryzhkov Alexander 
Published: February 2022

AbstractMost existing cloud models tend to overestimate the size of cloud ice particles and underestimate their concentration. This emphasizes the need to provide a reliable observational reference to optimize cloud model performance, particularly in areas of high concentration of ice at high altitudes. The dual‐polarization radars give the community a unique opportunity to quantify cloud ice with a good accuracy using polarimetric radar retrievals. In this study, we utilize the network of operational WSR‐88D radars to build a climatology of the vertical profiles of radar variables, such as radar reflectivity Z, differential reflectivity ZDR, and specific differential phase KDP as well as the radar‐retrieved vertical profiles of ice water content (IWC) above the melting layer and liquid water content below it, mean volume diameter Dm, and total number concentration Nt of ice and liquid particles. Such climatology was created for continental/marine mesoscale convective systems (MCSs) and tropical cyclones including hurricanes. The dataset includes 13 continental MCSs, 10 marine MCSs, and 11 tropical cyclones. Separate statistics of the “background” vertical profiles and the ones associated with high IWC aloft have been obtained in the course of this study. It is shown that continental MCSs exhibit larger size of ice in lower concentration aloft compared to the marine MCSs and especially tropical cyclones/hurricanes. A combination of high KDP and low Z aloft signifies lower Dm, higher Nt, and often substantial IWC.
LIGHT enhanced bispecific antibody armed T-cells to treat immunotherapy resistant colon cancer
Authors: Qiao Guilin , Kone Lyonell B. , Phillips Evan H. , Lee Steve Seung-Young , Brown Grace E. , Khetani Salman R. , Thakur Archana , Lum Lawrence G. , Prabhakar Bellur S. , Maker Ajay V. 
Published: February 2022

Abstract
Increased tumor infiltrating lymphocytes (TIL) are associated with improved patient responses to immunotherapy. As a result, there is interest in enhancing lymphocyte trafficking particularly to colon cancers since the majority are checkpoint blockade-resistant and microsatellite stable. Here, we demonstrate that activated T-cells (ATC) armed with anti-CD3 x anti-EGFR bispecific antibody increases TIL and mediate anti-tumor cytotoxicity while decreasing tumor cell viability. Furthermore, treatment induces endogenous anti-tumor immunity that resisted tumor rechallenge and increased memory T-cell subsets in the tumor. When combined with targeted tumor expression of the tumor necrosis factor superfamily member LIGHT, activated T-cell proliferation and infiltration were further enhanced, and human colorectal tumor regressions were observed. Our data indicate that tumor-targeted armed bispecific antibody increases TIL trafficking and is a potentially potent strategy that can be paired with combination immunotherapy to battle microsatellite stable colon cancer.

Significance
Enhancing trafficking of tumor infiltrating lymphocytes (TILs) to solid tumors has been shown to improve outcomes. Unfortunately, few strategies have been successful in the clinical setting for solid tumors, particularly for “cold” microsatellite stable colon cancers. In order to address this gap in knowledge, this study combined TNFSF14/LIGHT immunomodulation with a bispecific antibody armed with activated T-cells targeted to the tumor. This unique T-cell trafficking strategy successfully generated anti-tumor immunity in a microsatellite stable colon cancer model, stimulated T-cell infiltration, and holds promise as a combination immunotherapy for treating advanced and metastatic colorectal cancer.
Adaptive NK cells undergo a dynamic modulation in response to human cytomegalovirus and recruit T cells in in vitro migration assays
Authors: Basílio-Queirós Débora , Venturini Letizia , Luther-Wolf Susanne , Dammann Elke , Ganser Arnold , Stadler Michael , Falk Christine S. , Weissinger Eva M. 
Published: February 2022

AbstractHuman cytomegalovirus (HCMV) reactivation remains a relevant complication after hematopoietic stem cell transplantation (HSCT) despite the great progress made in prophylaxis and treatment. Adaptive Natural Killer (NK) cells undergo a persistent reconfiguration in response to HCMV reactivation however, the exact role of adaptive NK cells in HCMV surveillance is currently unknown. We studied the relationship between HCMV reactivation and adaptive NK cells in 70 patients monitored weekly until day +100 after HSCT. Absolute cell counts of adaptive NK cells increased significantly after resolution of HCMV-reactivation compared to patients without reactivation. Patients with HCMV-reactivation had an early reconstitution of adaptive NK cells (“Responders”) and had mainly a single reactivation (75% Responders vs 48% Non-Responders). Adaptive NK cells eliminated HCMV-infected human foreskin fibroblasts (HFF) in vitro and recruited T cells in an in vitro transwell migration assay. An extensive cytokine/chemokine panel demonstrated strongly increased secretion of CXCL10/IP-10, IFN-α, IL-1α, IL-1β, IL-5, IL-7 and CCL4. Thus, adaptive NK cells may control viral spread and T cell expansion and survival during HCMV-reactivation. Taken together, we have demonstrated the potential of adaptive NK cells in the control of HCMV reactivation both by direct cytotoxicity and by recruitment of other immune cells.
A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration
Authors: Bikman Benjamin T. , Shimy Kim J. , Apovian Caroline M. , Yu S. , Saito Erin R. , Walton Chase M. , Ebbeling Cara B. , Ludwig David S. 
Published: February 2022

AbstractAdipocyte mitochondrial respiration may influence metabolic fuel partitioning into oxidation versus storage, with implications for whole-body energy expenditure. Although insulin has been shown to influence mitochondrial respiration, the effects of dietary macronutrient composition have not been well characterized. The aim of this exploratory study was to test the hypothesis that a high-carbohydrate diet lowers the oxygen flux of adipocyte mitochondria ex vivo. Among participants in a randomized-controlled weight-loss maintenance feeding trial, those consuming a high-carbohydrate diet (60% carbohydrate as a proportion of total energy, n = 10) had lower rates of maximal adipose tissue mitochondrial respiration than those consuming a moderate-carbohydrate diet (40%, n = 8, p = 0.039) or a low-carbohydrate diet (20%, n = 9, p = 0.005) after 10 to 15 weeks. This preliminary finding may provide a mechanism for postulated calorie-independent effects of dietary composition on energy expenditure and fat deposition, potentially through the actions of insulin on fuel partitioning.
Teaching home tonometry using a remote video link
Authors: Barbour-Hastie Catriona C. , Tatham Andrew J. 
Published: February 2022

Abstract
Background/Objectives
Intraocular pressure (IOP) is the primary modifiable risk factor in the progression of glaucoma. The ICare HOME is a self-tonometer which empowers patients to measure their own IOP and allows a more complete picture of diurnal IOP. This project aims to determine the feasibility of teaching patients to perform self-tonometry remotely using a remote video link.

Subjects/Methods
This prospective study involved 12 patients with glaucoma attending an outpatient ophthalmology clinic. Participants were provided with a rebound tonometer (Icare HOME) and instructions to attend remote teaching from home. An optometrist conducted a 30 min live video training session via NearMe with each patient. Following training, participants were asked to measure their own IOP, observed remotely by the optometrist. Successful participants were asked to take a series of home IOP measurements over 48 h. Questionnaires were used to evaluate perceptions on home tonometry and remote training.

Results
Participants had an average age of 60.1 ± 15.5 years. 58% (7 of 12) were female. 83% (10 of 12) obtained successful diurnal measurements at home. All participants were happy with remote teaching, and none would have preferred training to be conducted face-to-face. All participants were interested in continuing home IOP monitoring.

Conclusions
Most patients were able to perform home tonometry successfully when taught remotely, with a success rate similar to previously reported rates for face-to-face teaching using the same device. Most participants were receptive to using video calling as a platform for teaching home tonometry.
Fine-mapping of intracranial aneurysm susceptibility based on a genome-wide association study
Authors: Hong Eun Pyo , Youn Dong Hyuk , Kim Bong Jun , Ahn Jun Hyong , Park Jeong Jin , Rhim Jong Kook , Kim Heung Cheol , Hwang Gyojun , Jeon Hong Jun , Jeon Jin Pyeong 
Published: February 2022

AbstractIn addition to conventional genome-wide association studies (GWAS), a fine-mapping analysis is increasingly used to identify the genetic function of variants associated with disease susceptibilities. Here, we used a fine-mapping approach to evaluate candidate variants based on a previous GWAS involving patients with intracranial aneurysm (IA). A fine-mapping analysis was conducted based on the chromosomal data provided by a GWAS of 250 patients diagnosed with IA and 296 controls using posterior inclusion probability (PIP) and log10 transformed Bayes factor (log10BF). The narrow sense of heritability (h2) explained by each candidate variant was estimated. Subsequent gene expression and functional network analyses of candidate genes were used to calculate transcripts per million (TPM) values. Twenty single-nucleotide polymorphisms (SNPs) surpassed a genome-wide significance threshold for creditable evidence (log10BF > 6.1). Among them, four SNPs, rs75822236 (GBA; log10BF = 15.06), rs112859779 (TCF24; log10BF = 12.12), rs79134766 (OLFML2A; log10BF = 14.92), and rs371331393 (ARHGAP32; log10BF = 20.88) showed a completed PIP value in each chromosomal region, suggesting a higher probability of functional candidate variants associated with IA. On the contrary, these associations were not shown clearly under different replication sets. Our fine-mapping analysis suggested that four functional candidate variants of GBA, TCF24, OLFML2A, and ARHGAP32 were linked to IA susceptibility and pathogenesis. However, this approach could not completely replace replication sets based on large-scale data. Thus, caution is required when interpreting results of fine-mapping analysis.
Graphitic sulfur functionalized carbon sheets as an efficient “turn-off” absorption probe for the optical sensing of mercury ions in aqueous solutions
Authors: Bharati Jaryal Vishal , Singh Dilbag , Gupta Neeraj 
Published: February 2022

The sulfur - rich activated carbon (g-SFCSs) derived from coconut husk is used for detection of Hg2+ ions. The presence of sulfur groups results in remarkable absorbance quenching of g-SFCSs on the addition of different concentrations of Hg2+ ions.
Calcified Abdominal aortic occlusion: Treatment using Intravascular Lithotripsy
Authors: Shah Pratik , Someshwar Vimal , Mundada Krishna , Raut Abhijit 
Published: February 2022

AbstractNear total occlusion of abdominal aorta due to atherosclerotic calcification is a challenging condition to treat. Though use of intravascular lithotripsy (IVL) has proven to be an effective technique in the treatment of calcified arterial lesions, the data on the use of the technique in high grade occlusion of aortic stenosis is still limited. We present a case of abdominal aortic calcification treatment in a patient using IVL technique.