bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effective sequence analysis of 113 genes in 1,192 probands with retinitis pigmentosa and Leber congenital amaurosis
Authors: Panneman Daan M. , Hitti-Malin Rebekkah J. , Holtes Lara K. , de Bruijn Suzanne E. , Reurink Janine , Boonen Erica G.M. , Khan Muhammad Imran , Ali Manir , Andréasson Sten , De Baere Elfride , Banfi Sandro , Bauwens Miriam , Ben-Yosef Tamar , Bocquet Béatrice , De Bruyne Marieke , de la Cerda Berta , Coppieters Frauke , Farinelli Pietro , Guignard Thomas , Inglehearn Chris F. , Karali Marianthi , Kjellström Ulrika , Koenekoop Robert , de Koning Bart , Leroy Bart P. , McKibbin Martin , Meunier Isabelle , Nikopoulos Konstantinos , Nishiguchi Koji M. , Poulter James A. , Rivolta Carlo , Rodríguez de la Rúa Enrique , Saunders Patrick , Simonelli Francesca , Tatour Yasmin , Testa Francesco , Thiadens Alberta A.H.J. , Toomes Carmel , Tracewska Anna M. , Viet Tran Hoai , Ushida Hiroaki , Vaclavik Veronika , Verhoeven Virginie J.M. , van de Vorst Maartje , Gilissen Christian , Hoischen Alexander , Cremers Frans P.M. , Roosing Susanne 
Published: November 2022

AbstractRetinitis pigmentosa (RP) and Leber congenital amaurosis (LCA) are two groups of inherited retinal diseases (IRDs) where the rod photoreceptors degenerate followed by the cone photoreceptors of the retina. A genetic diagnosis for IRDs is challenging since >280 genes are associated with these conditions. While whole exome sequencing (WES) is commonly used by diagnostic facilities, the costs and required infrastructure prevent its global applicability. Previous studies have shown the cost-effectiveness of sequence analysis using single molecule Molecular Inversion Probes (smMIPs) in a cohort of patients diagnosed with Stargardt disease and other maculopathies. Here, we introduce a smMIPs panel that targets the exons and splice sites of all currently known genes associated with RP and LCA, the entireRPE65gene, known causative deep-intronic variants leading to pseudo-exons, and part of the RP17 region associated with autosomal dominant RP, by using a total of 16,812 smMIPs. The RP-LCA smMIPs panel was used to screen 1,192 probands from an international cohort of predominantly RP and LCA cases. After genetic analysis, a diagnostic yield of 56% was obtained which is on par with results from WES analysis. The effectiveness and the reduced costs compared to WES renders the RP-LCA smMIPs panel a competitive approach to provide IRD patients with a genetic diagnosis, especially in countries with restricted access to genetic testing.
Determinants associated with preterm births in Uganda: A cross-sectional study
Authors: Nkeeto Bill , Yawe Bruno L. , Matovu Fred 
Published: November 2022

AbstractBackgroundPreterm births affect households’ incomes through direct and indirect expenditures associated with low productivity and the actual loss of employment in many cases. We studied the determinants of preterm birth in Uganda as one of the major contributors to neonatal morbidity and mortality, leading to households’ economic losses.MethodsWe used a cross-sectional research design based on the most recent Uganda Demographic Health Survey of 2016. The sample contained 1,537 women aged 15-49 years. The variable selection process was guided by categorization of the variables into; socio-demographic, reproductive history, and gestational birth characteristics. The study adopted two means of analysis. The logistic regression model to determine variables of preterm birth between 22 – 36 weeks and normal delivery period. Then the multinomial logistic regression model to determine how two preterm birth categories (22 – 32 weeks and 33 – 36 weeks) relate with the normal delivery period.ResultsBelonging to the poorest quintile (AOR2.09, 95% CI (1.69-2.57)) and attending antenatal care less than four times (AOR1.41, 95% CI (1.20-1.66)) had the highest odds ratios for the logistic regression model. Whereas the multinomial logistic regression model; for the 22-32 weeks category, belonging to the poorest quintile (RRR2.43, 95% CI(1.45-4.08)), attending antenatal care less than four times (RRR2.44, 95% CI (1.63-3.64)), had the highest relative risk ratios. For the 33-36 weeks category; belonging to a poorest quintile (RRR2.03, 95% CI (1.62-2.53)), having had less than four antenatal visits (RRR1.29, 95% CI (1.09-1.54)), and unwanted pregnancy (RRR1.22, 95% CI (1.03-1.45)), had the highest relative risk ratios.ConclusionAttending antenatal care for less than four times and belonging to the poorest quintile are common risk factors related to preterm birth. We therefore recommend that these receive utmost attention from the policy makers and implementers.
Korean vegetarian values: ethics, sustainability and quality of life
Authors: Kim Gahyun , Oh Jieun , Cho Mi Sook 
Published: November 2022

PurposeVegetarian diets are increasingly common worldwide. Vegetarianism is no longer just related to food, but rather it evokes a deeper meaning, such as environmental sustainability and animal welfare. In Western cultures, many studies have examined how vegetarians' motivations relate to animal welfare, health and environmentalism. However, there is little research in this area in Asia, especially in South Korea, despite a growing number of vegetarians. This study identifies the hierarchical value maps (HVMs) of vegetarians to clarify why people choose to become vegetarians and investigates the negative aspects of these dietary types.Design/methodology/approachThe authors conducted in-depth, one-to-one laddering interviews with 33 vegetarians in South Korea based on the means-end chain theory. The laddering technique is a qualitative approach to determining connections between attributes, consequences and values.FindingsVegetarians tend to value an ethical lifestyle, sustainable future, ecological circulation, responsibility for nature, respect for life, respect for the weak and quality of life. HVM differs slightly among groups by the type of vegetarianism (vegan vs non-vegan vegetarians) and sex (females vs males). The most dominant cognitive structures toward vegetarian diets were “meat-free,” “no factory farming,” and “plant-based” (attributes); “health,” “environment-friendly” and “animal-friendly” (consequences); and “quality of life,” “ethical life,” and “sustainable future” (values).Originality/valueThis study offers insights into the motivations of Korean vegetarians, and they are not culturally different from those of Westerners as they relate to animals, the environment and health.
How authentic leadership affects green creativity: the role of self-reflection and psychological capital
Authors: Wang Zhining , Guan Chunjie , Cai Shaohan 
Published: November 2022

Purpose
Based on social cognitive theory, this study aims to explore the effect of authentic leadership on employee green creativity by studying the mediating role of reflection and rumination and the moderating role of psychological capital.

Design/methodology/approach
This study used experience sampling methodology to test hypothesis. Specifically, this study applied two-level path analysis to analyze 1,290 observations from 129 employees.

Findings
The results show that authentic leadership positively influences reflection but negatively influences rumination, which in turn impact employees’ green creativity. Psychological capital positively moderates the effects of authentic leadership on reflection and negatively moderates the effects of authentic leadership on rumination. Furthermore, psychological capital moderates the linkages between authentic leadership, self-reflection and employee green creativity.

Practical implications
Organizations should make efforts in promoting authentic leadership and recruiting employees who possess high psychological capital. Moreover, managers can make effective efforts to stimulate employees’ reflection and mitigate rumination, thereby facilitating organizational sustainable development.

Originality/value
In investigating green issues related to employees’ daily cognitive processes, this study focuses on within-personal reaction mechanism to authentic leadership, concerning the moderating effect of individual psychological capital.
The dynamic interdependence structure and risk spillover effect between Sino-US stock markets
Authors: Chen Menggen , Zhou Yuanren 
Published: November 2022

PurposeThe purpose of this paper is to explore the dynamic interdependence structure and risk spillover effect between the Chinese stock market and the US stock market.Design/methodology/approachThis paper mainly uses the multivariate R-vine copula-complex network analysis and the multivariate R-vine copula-CoVaR model and selects stock price indices and their subsector indices as samples.FindingsThe empirical results indicate that the Energy, Materials and Financials sectors have leading roles in the interdependent structure of the Chinese and US stock markets, while the Utilities and Real Estate sectors have the least important positions. The comprehensive influence of the Chinese stock market is similar to that of the US stock market but with smaller differences in the influence of different sectors of the US stock market on the overall interdependent structure system. Over time, the interdependent structure of both stock markets changed; the sector status gradually equalized; the contribution of the same sector in different countries to the interdependent structure converged; and the degree of interaction between the two stock markets was positively correlated with the degree of market volatility.Originality/valueThis paper employs the methods of nonlinear cointegration and the R-vine copula function to explore the interactive relationship and risk spillover effect between the Chinese stock market and the US stock market. This paper proposes the R-vine copula-complex network analysis method to creatively construct the interdependent network structure of the two stock markets. This paper combines the generalized CoVaR method with the R-vine copula function, introduces the stock market decline and rise risk and further discusses the risk spillover effect between the two stock markets.
Generation “Z” willingness to participate in crowdshipping services to achieve sustainable last-mile delivery in emerging market
Authors: Upadhyay Chandra Kant , Tiwari Vijayshri , Tiwari Vineet 
Published: November 2022

PurposeThe purpose of this paper is to provide trilogy in the emerging market for the establishment of business, economy and environment which is the new word for the development of any nation to attain sustainable development. This research explores the prospective crowdshipper's willingness to participate in crowdshipping services through a motivational factor.Design/methodology/approachTo understand the trend and future of this concept, Google Trends Analysis (GTA) has been used. The theoretical model has been validated empirically using a survey of 287 Indian (Generation Y and Z) urban participants, but focused is on Generation “Z” participants and subsequent analysis have been carried out using structural equation modelling.FindingsA theoretical framework has been developed connecting the various factions of the crowdsourcing process thus providing an overall view of the process strategy for logistics start-ups. This conceptual framework of sharing economy in emerging market can benefit the prospective suppliers and their target receivers. Particularly trust in crowdshipper plays a significant mediating role between subject factors and next generation user willingness to participate in crowdshipping services for sustainable last-mile delivery.Originality/valueThe present theoretical foundations and frameworks have been studied to get an idea of the main aspects of the field. It has the potential to provide the impetus for collaboration with the various stakeholders thus achieving the sustainable development process. The practical inference of this study is the usability in terms of the plugin application for e-retailer in emerging markets.
Sliding contact performance of injection moulded and selective laser sintered polyamide under dry and lubricated conditions
Authors: Bharti Sarita , Selvaraj Senthilvelan 
Published: November 2022

Purpose
This paper aims to understand the effect of the manufacturing process on the frictional and wear performance of polyamide.

Design/methodology/approach
Pin specimens were manufactured through injection moulding (IM) and selective laser sintering (SLS) manufacturing processes. The friction and wear performance was evaluated using a pin-on-disc configuration under dry and oil-lubricated conditions. The friction coefficient, wear resistance and surface temperature of specimens were measured, and failure morphology analysis was carried out to understand the mechanism.

Findings
SLS material exhibited significantly less friction, wear and surface temperature than IM material under dry conditions. Reduced ductility due to the sintering contributes to reduced friction, wear and heat generation. Under the dry condition, IM material exhibited plastic flow and roll-shaped deformation, whereas SLS material exhibited only local degradation due to its lesser ductility. Lubrication reduced friction and temperature for both SLS and IM materials. The porous nature of the sintered surface absorbed the lubricant and released it while sliding, which is confirmed by the brown-coloured wear track.

Originality/value
The study provides valuable input to the designers on the sliding contact performance of commonly adopted two different manufacturing processes of polymers; IM and SLS manufacturing.
Challenges of offsite construction and BIM implementation: providing a framework for integration in New Zealand
Authors: Kordestani Ghalenoei Nazanin , Babaeian Jelodar Mostafa , Paes Daniel , Sutrisna Monty 
Published: November 2022

PurposeThe development of prefabrication into full-scale offsite manufacturing processes in the construction industry is paradigm-shifting. Moreover, Building Information Modelling (BIM) is becoming the primary mode of communication and integration in construction projects to facilitate the flow of information. Although research has been performed on BIM and Offsite Construction (OSC), integrating these two concepts remains ambiguous and complex and lacks documentation and structure, especially in New Zealand. Therefore, this paper develops a robust framework for OSC and BIM integration. The study focusses on identifying integration challenges and proposes strategies for overcoming these challenges.Design/methodology/approachThis study applied scientometric analysis, a systematic literature review (SLR) and semi-structured expert interviews to investigate OSC and BIM integration challenges. Multiple themes were investigated and triangulation conducted in this research supports the creation of applicable knowledge in this field.FindingsMultiple gaps, research trends and the pioneer countries in the paper's scope have been identified through scientometric analysis. Then, a classified cluster of challenges for OSC and BIM implementation and integration strategies of OSC and BIM were demonstrated from the findings. The interviews provided comprehensive and complementary data sets and analyses. The findings from the Systematic Literature Review and interview structured the integration framework.Originality/valueThe contribution of this paper to existing knowledge is a developed framework that serves as a guideline for the OSC stakeholders. This framework can assess OSC's alignment with BIM and consolidate strategies for incorporating OSC into a BIM-based project delivery process. The framework consists of 23 strategies categorised into 8 clusters: a policy document, training and professional development, documentation, technology management, governmental development, contract development, accurate definition and detailing and communication. The proposed strategies will streamline integration by reducing potential challenges, thus enhancing project productivity.
Characteristics of seafloor ambient noise under different sea ice concentrations in the northern Chukchi Sea: Results from the N11 CHINARE ocean‐bottom seismic experiment
Authors: Xing Junhui , Xu Haowei , Jiang Xiaodian , Chen Wenwen 
Published: November 2022

AbstractSeafloor ambient noise in the Arctic Ocean is related to sea ice. The characteristics of low‐frequency seafloor ambient noise (<10 Hz) in the northern Chukchi Sea have rarely been reported. Here, we investigated the seafloor ambient noise recorded using ocean‐bottom seismometers in the northern Chukchi Sea under four different sea ice‐concentration periods from 3 to 23 August 2020, in the 11th Chinese National Arctic Research Expedition. The causes and mechanisms of the changes in seafloor ambient noise that correspond to the variation in sea ice concentration were discussed. The energy of infragravity waves and primary microseisms is weak compared with other oceans. Combined with the analysis of land station, we argue that the variations in sea ice extent have little effect on the energy of the primary microseisms and infragravity waves. The power of secondary microseisms is growth with the loss of sea ice and is influenced by storms. We find that a high concentration of sea ice can impede the process of storm‐sea surface interaction, which in turn affects the power of microseisms inspired by storm.
Confocal laser microscopy for assessment of surgical margins during radical prostatectomy
Authors: Baas Diederik J.H. , Vreuls Willem , Sedelaar J.P. Michiel , Vrijhof Henricus J.E.J. , Hoekstra Robert J. , Zomer Saskia F. , van Leenders Geert J.L.H. , van Basten Jean‐Paul A. , Somford Diederik M. 
Published: November 2022

ObjectiveTo evaluate the feasibility of confocal laser microscopy (CLM) for intraoperative margin assessment as faster alternative to neurovascular structure‐adjacent frozen‐section examination (NeuroSAFE) during robot‐assisted radical prostatectomy (RARP).Patients and MethodsSurgical margins were assessed during 50 RARP procedures in patients scheduled for NeuroSAFE. Posterolateral sections were cut and imaged with CLM and further processed to conform with the NeuroSAFE protocol. Secondary resection (SR) was performed in case a positive surgical margin (PSM) was observed with NeuroSAFE. Afterwards, the CLM images were non‐blinded assessed for the presence of PSMs. The accuracy of both NeuroSAFE and CLM was compared with conventional histopathology. Agreement for detection of PSMs between NeuroSAFE and CLM was evaluated with Cohen's kappa coefficient. Procedure times were compared with a Wilcoxon signed‐ranks test.ResultsIn total, 96 posterolateral sections of RP specimens were evaluated for the presence of PSMs. CLM identified 15 (16%) PSMs and NeuroSAFE identified 14 (15%) PSMs. CLM had a calculated sensitivity, specificity, positive predictive value and negative predictive value of 86%, 96%, 80% and 98% respectively for the detection of PSMs compared to definite pathology. After SR, residual tumour was found in six of 13 cases (46%), which were all identified by both techniques. There was a substantial level of agreement between CLM and NeuroSAFE (κ = 0.80). The median procedure time for CLM was significantly shorter compared to NeuroSAFE (8 vs 50 min, P < 0.001). The main limitation of this study was the non‐blinded assessment of the CLM images.ConclusionsCompared to NeuroSAFE, CLM is a promising technique for intraoperative margin assessment and is able to reduce the time of intraoperative margin assessment.
Inhibition of dopamine receptor D1 signaling promotes human bile duct cancer progression via WNT signaling
Authors: Yogo Akitada , Masui Toshihiko , Takaishi Shigeo , Masuo Kenji , Chen Ru , Kasai Yosuke , Nagai Kazuyuki , Anazawa Takayuki , Watanabe Sadanori , Sakamoto Satoko , Watanabe Akira , Inagaki Ryosaku , Nakagawa Masahiro M. , Ogawa Seishi , Seno Hiroshi , Uemoto Shinji , Hatano Etsuro 
Published: November 2022

AbstractBile duct cancer (BDC) frequently invades the nerve fibers, making complete surgical resection difficult. A single tumor mass contains cells of variable malignancy and cell‐differentiation states, with cancer stem cells (CSCs) considered responsible for poor clinical outcomes. This study aimed to investigate the contribution of autosynthesized dopamine to CSC‐related properties in BDC. Sphere formation assays using 13 commercially available BDC cell lines demonstrated that blocking dopamine receptor D1 (DRD1) signaling promoted CSC‐related anchorage‐independent growth. Additionally, we newly established four new BDC patient‐derived organoids (PDOs) and found that blocking DRD1 increased resistance to chemotherapy and enabled xenotransplantation in vivo. Single‐cell analysis revealed that the BDC PDO cells varied in their cell‐differentiation states and responses to dopamine signaling. Further, DRD1 inhibition increased WNT7B expression in cells with bile duct‐like phenotype, and it induced proliferation of other cell types expressing Wnt receptors and stem cell‐like signatures. Reagents that inhibited Wnt function canceled the effect of DRD1 inhibition and reduced cell proliferation in BDC PDOs. In summary, in BDCs, DRD1 is a crucial protein involved in autonomous CSC proliferation through the regulation of endogenous WNT7B. As such, inhibition of the DRD1 feedback signaling may be a potential treatment strategy for BDC.
Need for approval and antisocial behavior moderate the effect of socioemotional cues on adolescent girls’ cognitive control
Authors: Modi Haina H. , Davis Megan M. , Troop Gordon Wendy , Telzer Eva H. , Rudolph Karen D. 
Published: November 2022

AbstractTo examine whether need for approval (NFA) and antisocial behavior (ASB) moderate the effects of socioemotional stimuli on cognitive control, 88 girls (Mage = 16.31 years; SD = 0.84; 65.9% White) completed a socioemotional Go/No‐go and questionnaires. At high approach NFA, girls responded more slowly during appetitive than control (b = −8.80, p < .01) and aversive (b = −5.58, p = .01) trials. At high ASB, girls responded more slowly (b = −6.12, p = .02) and less accurately (OR = 1.11, p = .03) during appetitive than aversive trials; at low ASB, girls responded more slowly during aversive than control trials (b = −4.42, p = .04). Thus, both context and individual differences influence adolescents' cognitive control.