bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolución del marketing mix y la creación de valor de marca en las cooperativas de ahorro y crédito
Authors: Maigua Chipantaxi Carla Mikaela , Lascano Pérez Luis Fabricio 
Published: April 2022

Introducción. En la actualidad el mundo se mantiene en persistente evolución y por ello, los mercados cada vez son más competitivos. En este caso las cooperativas de ahorro y crédito en la actualidad han tenido un gran crecimiento y por ello se han acoplado a las nuevas tecnologías, para brindar un mejor servicio a los socios. En este contexto, todas las cooperativas deberían aplicar estrategias de marketing con la finalidad de crecer, innovar, competir y mejorar. La presente investigación tiene como finalidad realizar un amplio análisis bibliográfico de la evolución de marketing mix y la creación de valor según Aaker. Objetivo. Analizar como las variables o dimensiones de las 4Es del marketing y el modelo Brand Equity, pueden trabajar simultáneamente para generar valor de marca. Metodología. Se realizó una investigación cualitativa y descriptiva de las 4Es del marketing y modelo Brand Equity, con el propósito de explicar las definiciones de las variables y como pueden trabajar para obtener grandes resultados en las COAC. Para ello se realizó un análisis inductivo, mediante una guía de observación, validada por expertos. Resultados. Se determinó que las variables experience, exchange, everyplace, evangelism, lealtad, notoriedad, calidad percibida y asociación de marca, pueden combinarse para generar estrategias en beneficios del sector cooperativista y sus socios. Conclusión. Las cooperativas de ahorro y crédito pueden generar estrategias combinando dichas variables para crear valor de marca y fidelizarlos a la misma.
Pengaruh Corporate Social Responsibility, Leverage, dan Woman On Board Terhadap Firm Value
Authors: Puspitasari Alien , Srimindarti Ceacilia 
Published: April 2022

Firm value (company value) is the value owned by a company company, whether it gets local or foreign capital obtained based on several important things that can build the company from the beginning until now. This preparation has the aim of testing and analyzing the effect of corporate social responsibility, leverage, and woman on board on firm value in manufacturing companies listed on the Indonesia Stock Exchange (IDX) in the last three periods, 2018-2020, with a population of 536 company. The sampling method used in this study is a purposive sampling technique with several selected criteria so as to obtain a sample of 258 companies. This study uses secondary data in the form of numbers that are processed into a statistical measurement scale. Data collection techniques using documentation techniques. The data analysis technique used is multiple linear regression analysis. The results of this study indicate that corporate social responsibility (CSR) and woman on board (WoB) have a negative effect on firm value. Meanwhile, leverage (DER) has a significant effect in a positive direction on firm value.

Keywords:corporate social responsibility; leverage; woman on board; firm value
Kesulitan Keuangan, Proporsi Hutang dan Peluang Investasi, Audit Delay: Peran Moderasi Dewan Komisaris Independen
Authors: Suhendi Reni , Firmansyah Amrie 
Published: April 2022

The accuracy of delivering information will be meaningful if presented on time because it benefits decision-making for its users. The delay in submitting financial statements causes erratic stock movements because investors assume that the company is experiencing problems. This study examines the effect of financial distress, debt proportion and investment opportunity set on audit delay moderated by an independent board of commissioners. This study uses secondary data sourced from www.idx.co.id. The data used consists of information on financial statements that have been audited and listed on the IDX from 2017 to 2020. The sample used in this study amounted to 440 observations based on purposive sampling. This study concludes that financial distress and debt proportion can prolong audit delays in companies. At the same time, the investment opportunity set can reduce audit delays. This study proves that the existence of independent commissioners in the company cannot supervise the company's financial condition and use of debt, which causes the audit delay to be longer. In addition, the independent board of commissioners is also unable to dominate the policies taken on planning in the company's investment activities. This research suggests that OJK needs to review the deadline for submitting financial reports related to the supervision of companies listed on the IDX and the protection of investors in the Indonesian capital market.
Keywords: financial distress; debt proportion; investment opportunity set
Pengaruh Budaya organisasi dan motivasi kerja terhadap disiplin kerja pegawai Kementerian Hukum dan HAM pada Lembaga Pemasyarakatan Perempuan Kelas II A Jakarta
Authors: Nugrohoseno Dwiarko , Hasibuan Aldi Martua 
Published: April 2022

This study aims to determine the effect of organizational culture and work motivation on the work discipline of Ministry Of Low And Human Rights employees at the Class II A Jakarta Women's Correctional Institution. This research is quantitative research. The sample used in this study amounted to 50 people. The sampling technique that will be used in this study is probability sampling using simple random sampling. Hypothesis testing carried out in this study is the Coefficient of Determination Test (R2), t-test and F-test using a significance level of 5% (0.05). The results of the test obtained (1) there is a positive and significant influence between organizational culture on employee work discipline, (2) there is a positive and significant influence between work motivation on employee work discipline, (3) and simultaneously there is a positive and significant influence between organizational culture and work motivation on employee work discipline
Analisis Faktor Penyebab Audit Delay
Authors: Hasanah Riswatul , Estiningrum Sri Dwi 
Published: April 2022

The study aimed to determine the effect of profitabilit and solvency on audit delay in financial services companies listed on the Indonesia Stock Exchange for the period 2019-2020. The study used a quantitative approach. The data collection tecnique was documentation, namely by collecting and recording the financial report of financial service companies listed on the Indonesia stock exchange for the period 2019-2020. The analysis technique used was multiple linier regressions. ANOVA the result showed that profitability and solvency owned simultaneous effect on audit delay.
Multivessel vs. Culprit Vessel-Only Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction in Patients With Cardiogenic Shock: An Updated Systematic Review and Meta-Analysis
Authors: Xiong Bingquan , Yang Huiping , Yu Wenlong , Zeng Yunjie , Han Yue , She Qiang 
Published: April 2022

BackgroundThe optimal revascularization strategy in patients with ST-segment elevation myocardial infarction (STEMI) complicating by cardiogenic shock (CS) remains controversial. This study aims to evaluate the clinical outcomes of multivessel percutaneous coronary intervention (MV-PCI) compared to culprit vessel-only PCI (CO-PCI) for the treatment, only in patients with STEMI with CS.MethodsA comprehensive literature search was conducted. Studies assessed the efficacy outcomes of short (in-hospital or 30 days)/long-term mortality, cardiac death, myocardial reinfarction, repeat revascularization, and safety outcomes of stroke, bleeding, acute renal failure with MV-PCI vs. CO-PCI in patients with STEMI with CS were included. The publication bias and sensitivity analysis were also performed.ResultsA total of 15 studies were included in this meta-analysis. There was no significant difference in short- and long-term mortality in patients treated with MV-PCI compared to CO-PCI group [odds ratio (OR) = 1.17; 95% confidence interval (CI), 0.92–1.48; OR = 0.86; 95% CI, 0.58–1.28]. Similarly, there were no significant differences in cardiac death (OR = 0.67; 95% CI, 0.44–1.00), myocardial reinfarction (OR = 1.24; 95% CI, 0.77–2.00), repeat revascularization (OR = 0.75; 95% CI, 0.40–1.42), bleeding (OR = 1.53; 95% CI, 0.53–4.43), or stroke (OR = 1.42; 95% CI, 0.90–2.23) between the two groups. There was a higher risk in acute renal failure (OR = 1.33; 95% CI, 1.04–1.69) in patients treated with MV-PCI when compared with CO-PCI.ConclusionThis meta-analysis suggests that there may be no significant benefit for patients with STEMI complicating CS treated with MV-PCI compared with CO-PCI, and patients are at increased risk of developing acute renal failure after MV-PCI intervention.
Association Between Early Oral β-Blocker Therapy and In-Hospital Outcomes in Patients With ST-Elevation Myocardial Infarction With Mild-Moderate Heart Failure: Findings From the CCC-ACS Project
Authors: Wang Miao , Liu Jing , Liu Jun , Hao Yongchen , Yang Na , Liu Tong , Smith Sidney C. , Huo Yong , Fonarow Gregg C. , Ge Junbo , Morgan Louise , Ma Changsheng , Han Yaling , Zhao Dong , Zhan Siyan 
Published: April 2022

BackgroundThere are limited data available on the impact of early (within 24 h of admission) β-blocker therapy on in-hospital outcomes of patients with ST-elevation myocardial infarction (STEMI) and mild-moderate acute heart failure. This study aimed to explore the association between early oral β-blocker therapy and in-hospital outcomes.MethodsInpatients with STEMI and Killip class II or III heart failure from the Improving Care for Cardiovascular Disease in China project (n = 10,239) were enrolled. The primary outcome was a combined endpoint composed of in-hospital all-cause mortality, successful cardiopulmonary resuscitation after cardiac arrest, and cardiogenic shock. Inverse-probability-of-treatment weighting, multivariate Cox regression, and propensity score matching were performed.ResultsEarly oral β-blocker therapy was administered to 56.5% of patients. The incidence of the combined endpoint events was significantly lower in patients with early therapy than in those without (2.7 vs. 5.1%, P &lt; 0.001). Inverse-probability-of-treatment weighting analysis demonstrated that early β-blocker therapy was associated with a low risk of combined endpoint events (HR = 0.641, 95% CI: 0.486–0.844, P = 0.002). Similar results were shown in multivariate Cox regression (HR = 0.665, 95% CI: 0.496–0.894, P = 0.007) and propensity score matching (HR = 0.633, 95% CI: 0.453–0.884, P = 0.007) analyses. A dose-response trend between the first-day β-blocker dosages and adverse outcomes was observed in a subset of participants with available data. No factor could modify the association of early treatment and the primary outcomes among the subgroups analyses.ConclusionBased on nationwide Chinese data, early oral β-blocker therapy is independently associated with a lower risk of poor in-hospital outcome in patients with STEMI and Killip class II or III heart failure.
A Novel Pyroptotic and Inflammatory Gene Signature Predicts the Prognosis of Cutaneous Melanoma and the Effect of Anticancer Therapies
Authors: Xu Yujian , Chen Youbai , Niu Zehao , Xing Jiahua , Yang Zheng , Yin Xiangye , Guo Lingli , Zhang Qixu , Qiu Haixia , Han Yan 
Published: April 2022

PurposeThe purpose of this study was to construct a gene signature comprising genes related to both inflammation and pyroptosis (GRIPs) to predict the prognosis of patients with cutaneous melanoma patients and the efficacy of immunotherapy, chemotherapy, and targeted therapy in these patients.MethodsGene expression profiles were collected from The Cancer Genome Atlas. Weighted gene co-expression network analysis was performed to identify GRIPs. Univariable Cox regression and Lasso regression further selected key prognostic genes. Multivariable Cox regression was used to construct a risk score, which stratified patients into high- and low-risk groups. Areas under the ROC curves (AUCs) were calculated, and Kaplan-Meier analyses were performed for the two groups, following validation in an external cohort from Gene Expression Omnibus (GEO). A nomogram including the GRIP signature and clinicopathological characteristics was developed for clinical use. Gene set enrichment analysis illustrated differentially enriched pathways. Differences in the tumor microenvironment (TME) between the two groups were assessed. The efficacies of immune checkpoint inhibitors (ICIs), chemotherapeutic agents, and targeted agents were predicted for both groups. Immunohistochemical analyses of the GRIPs between the normal and CM tissues were performed using the Human Protein Atlas data. The qRT-PCR experiments validated the expression of genes in CM cell lines, Hacat, and PIG1 cell lines.ResultsA total of 185 GRIPs were identified. A novel gene signature comprising eight GRIPs (TLR1, CCL8, EMP3, IFNGR2, CCL25, IL15, RTP4, and NLRP6) was constructed. The signature had AUCs of 0.714 and 0.659 for predicting 3-year overall survival (OS) in the TCGA entire and GEO validation cohorts, respectively. Kaplan-Meier analyses revealed that the high-risk group had a poorer prognosis. Multivariable Cox regression showed that the GRIP signature was an independent predictor of OS with higher accuracy than traditional clinicopathological features. The nomogram showed good accuracy and reliability in predicting 3-year OS (AUC = 0.810). GSEA and TME analyses showed that the high-risk group had lower levels of pyroptosis, inflammation, and immune response, such as lower levels of CD8+ T-cell infiltration, CD4+ memory-activated T-cell infiltration, and ICI. In addition, low-risk patients whose disease expressed PD-1 or CTLA-4 were likely to respond better to ICIs, and several chemotherapeutic and targeted agents. Immunohistochemical analysis confirmed the distinct expression of five out of the eight GRIPs between normal and CM tissues.ConclusionOur novel 8-GRIP signature can accurately predict the prognosis of patients with CM and the efficacies of multiple anticancer therapies. These GRIPs might be potential prognostic biomarkers and therapeutic targets for CM.
Latin Dance and Working Memory: The Mediating Effects of Physical Activity Among Middle-Aged and Older Latinos
Authors: Aguiñaga Susan , Kaushal Navin , Balbim Guilherme M. , Wilson Robert S. , Wilbur JoEllen E. , Hughes Susan , Buchner David M. , Berbaum Michael , McAuley Edward , Vásquez Priscilla M. , Marques Isabela G. , Wang Tianxiu , Marquez David X. 
Published: April 2022

BackgroundPhysical activity (PA) is a promising method to improve cognition among middle-aged and older adults. Latinos are at high risk for cognitive decline and engaging in low levels of PA. Culturally relevant PA interventions for middle-aged and older Latinos are critically needed to reduce risk of cognitive decline. We examined changes in cognitive performance among middle-aged and older Latinos participating in the BAILAMOS™ dance program or a health education group and compared the mediating effects of PA between group assignment and change in cognitive domains.MethodsOur 8-month randomized controlled trial tested BAILAMOS™, a 4-month Latin dance program followed by a 4-month maintenance phase. A total of 333 older Latinos aged 55+ were randomized to either BAILAMOS™, or to a health education control group. Neuropsychological tests were administered, scores were converted to z-scores, and specific domains (i.e., executive function, episodic memory, and working memory) were derived. Self-reported PA was assessed, and we reported categories of total PA, total leisure PA, and moderate-to-vigorous PA as minutes/week. A series of ANCOVAs tested changes in cognitive domains at 4 and 8 months. A mediation analysis tested the mediating effects of each PA category between group assignment and a significant change in cognition score.ResultsThe ANCOVAs found significant improvement in working memory scores among participants in the dance group at month 8 [F(1,328) = 5.79, p = 0.017, d = 0.20], but not in executive functioning [F(2,328) = 0.229, p = 0.80, Cohen’s d = 0.07] or episodic memory [F(2,328) = 0.241, p = 0.78, Cohen’s d = 0.05]. Follow-up mediation models found that total PA mediated the relationship between group assignment and working memory, in favor of the dance group (β = 0.027, 95% CI [0.0000, 0.0705]). Similarly, total leisure PA was found to mediate this relationship [β = 0.035, 95% CI (0.0041, 0.0807)].ConclusionA 4-month Latin dance program followed by a 4-month maintenance phase improved working memory among middle-aged and older Latinos. Improvements in working memory were mediated by participation in leisure PA. Our results support the current literature that leisure time PA influences cognition and highlight the importance of culturally relevant PA modalities for Latinos.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [NCT01988233].
Assessing the Effects of COVID-19 on Restaurant Business From Restaurant Owners’ Perspective
Authors: Sardar Sazu , Ray Rudrendu , Hasan Md. Kamrul , Chitra Shital Sohani , Parvez A. T. M. Shahed , Avi Md. Ashikur Rahman 
Published: April 2022

PurposeThe main purpose of this study is to assess the effects of COVID-19 on the restaurant businesses of Bangladesh. It examines the socio-economic impacts of the humanitarian disaster of the COVID-19 pandemic from the perspective of restaurant owners. The study also intends to provide recommendations to mitigate effects on the restaurant business.Design/Methodology/ApproachA qualitative research approach was adopted to explore the effects of the COVID-19 pandemic on the restaurant businesses of Bangladesh. A total of 22 in-depth interviews were conducted with the top-ranked restaurant owners in the Rajshahi City Corporation area of Bangladesh. Thematic analysis technique was applied for analyzing the collected data.FindingsThe study found that the restaurant owners were compelled to reduce their number of employees, and forced to ensure social distancing and proper sanitization which increased the expenses. Although online orders and home delivery services have increased significantly, restaurant business operation is gradually turning critical owing to the lack of financial support. Thus, restaurant owners urge the govenrment for financial assistance.Research Limitations/ImplicationsSince this research only focused on one city in Bangladesh, the outcomes of study may have a dearth of generalizability. Hence, the investigators are encouraged to extend the study area.Practical ImplicationsThis study will help restaurant owners and policymakers in formulating contemporary business policies and strategies. Thus, it will be supportive of improving the present condition of the restaurant businesses in developing countries like Bangladesh.Originality/ValueThis paper identified the truculent scenario of the restaurant business during the COVID-19 pandemic.
“Disruptive Behavior” or “Expected Benefit” Are Rationales of Seclusion Without Prior Aggression
Authors: Vruwink Fleur J. , VanDerNagel Joanneke E. L. , Noorthoorn Eric O. , Nijman Henk L. I. , Mulder Cornelis L. 
Published: April 2022

ObjectiveIn the Netherlands, seclusion of patients with a psychiatric disorder is a last-resort measure to be used only in the event of (imminent) severe danger or harm. Although aggressive behavior is often involved, seclusions not preceded by aggression also seem to occur. We sought insight into the non-aggressive reasons underlying seclusion and investigated the factors associated with it.MethodWe included all patients admitted to a Dutch psychiatric hospital in 2008 and 2009. Seclusions had been registered on Argus-forms, and aggression incidents had been registered on the Staff Observation Aggression Scale-Revised (SOAS-R), inspectorate forms and/or patient files. Determinants of seclusion with vs. without prior aggression were analyzed using logistic regression. Reasons for seclusion without prior aggression were evaluated qualitatively and grouped into main themes.ResultsOf 1,106 admitted patients, 184 (17%) were secluded at some time during admission. Twenty-one (11.4%) were excluded because information on their seclusion was lacking. In 23 cases (14%), neither SOAS-R, inspectorate forms nor individual patient files indicated any aggression. Univariable and multivariable regression both showed seclusion without preceding aggression to be negatively associated with daytime and the first day of hospitalization. In other words, seclusion related to aggression occurred more on the first day, and during daytime, while seclusion for non-aggressive reasons occurred relatively more after the first day, and during nighttime. Our qualitative findings showed two main themes of non-aggressive reasons for seclusion: “disruptive behavior” and “beneficial to patient.”ConclusionAwareness of the different reasons for seclusion may improve interventions on reducing its use. Thorough examination of different sources showed that few seclusions had not been preceded by aggression. The use of seclusion would be considerably reduced through interventions that prevent aggression or handle aggression incidents in other ways than seclusion. However, attention should also be paid to the remaining reasons for seclusion, such as handling disruptive behavior and focusing on the beneficial effects of reduced stimuli. Future research on interventions to reduce the use of seclusion should not only aim to reduce seclusion but should also establish whether seclusions preceded by aggression decrease different from seclusions that are not preceded by aggression.
A Novel Nomogram for Predicting Post-Operative Sepsis for Patients With Solitary, Unilateral and Proximal Ureteral Stones After Treatment Using Percutaneous Nephrolithotomy or Flexible Ureteroscopy
Authors: Sun Jian-Xuan , Xu Jin-Zhou , Liu Chen-Qian , Xun Yang , Lu Jun-lin , Xu Meng-Yao , An Ye , Hu Jia , Li Cong , Xia Qi-Dong , Wang Shao-Gang 
Published: April 2022

BackgroundThe postoperative sepsis is a latent fatal complication for both flexible ureteroscopy (fURS) and percutaneous nephrolithotomy (PNL). An effective predictive model constructed by readily available clinical markers is urgently needed to reduce postoperative adverse events caused by infection. This study aims to determine the pre-operative predictors of sepsis in patients with unilateral, solitary, and proximal ureteral stones after fURS and PNL.MethodsWe retrospectively enrolled 910 patients with solitary proximal ureteral stone with stone size 10–20 mm who underwent fURS or PNL from Tongji Hospital's database, including 412 fURS cases and 498 PNL cases. We used the least absolute shrinkage and selection operator (LASSO) regression and multivariate logistic regression analysis to identify the risk factors for sepsis. Finally, a nomogram was assembled utilizing these risk factors.ResultsIn this study, 49 patients (5.4%) developed sepsis after fURS or PNL surgery. Lasso regression showed postoperative sepsis was associated with gender (female), pre-operative fever, serum albumin (&lt;35 g/L), positive urine culture, serum WBC (≥10,000 cells/ml), serum neutrophil, positive urine nitrite and operation type (fURS). The multivariate logistic analysis indicated that positive urine culture (odds ratio [OR] = 5.9092, 95% CI [2.6425–13.2140], p &lt; 0.0001) and fURS (OR = 1.9348, 95% CI [1.0219–3.6631], p = 0.0427) were independent risk factors of sepsis and albumin ≥ 35g/L (OR = 0.4321, 95% CI [0.2054–0.9089], p = 0.0270) was independent protective factor of sepsis. A nomogram was constructed and exhibited favorable discrimination (area under receiver operating characteristic curve was 0.78), calibration [Hosmer–Lemeshow (HL) test p = 0.904], and net benefits displayed by decision curve analysis (DCA).ConclusionsPatients who underwent fURS compared to PNL or have certain pre-operative characteristics, such as albumin &lt;35 g/L and positive urine culture, are more likely to develop postoperative sepsis. Cautious preoperative evaluation and appropriate operation type are crucial to reducing serious infectious events after surgery, especially for patients with solitary, unilateral, and proximal ureteral stones sized 10–20 mm.