bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporary Employment, Employee Representation, and Employer-Paid Training: A Comparative Analysis
Authors: Adolfsson Maja , Baranowska-Rataj Anna , Lundmark Anneli 
Published: April 2022

Abstract
This article examines the moderating role of employee representation on the chances of receiving employer-paid training among temporary and permanent workers from a cross-country, comparative perspective. The impact of employee representation is considered at the individual level and at the country level. The statistical analyses are performed using data from the 2015 European Working Conditions Survey and multilevel modelling. Our results suggest that temporary workers receive less employer-paid training than permanent workers. Access to employee representation increases workers’ access to employer-paid training, regardless of contract type. At the country level, we found that the training-related benefits from union coverage are larger for permanent than for temporary workers. Our findings suggest that employee representation in the workplace could operate as an equalizer between temporary and permanent workers; while at the country level, the lobbying effect of union coverage is more beneficial for permanent workers.
Down-regulation of ABCB1 by collateral sensitivity drugs reverses multidrug resistance and up-regulates enolase I
Authors: Limniatis Georgia , Georges Elias 
Published: April 2022

AbstractThe emergence of drug resistance remains an obstacle in the clinical treatment of cancer. Recent developments in the studies of drug resistance have identified compounds such as verapamil and tamoxifen that specifically target ABCB1-expressing multidrug-resistant (MDR) cells, through an ATP-dependent ROS-generating mechanism. In this report, we demonstrate that treatment of ABCB1-expressing MDR cells (CHORC5 or MDA-Doxo400) or individual clones of the latter with sub-lethal concentrations of tamoxifen or verapamil down-regulates ABCB1 protein and mRNA expression in surviving clones. Consequently, tamoxifen- and verapamil-treated cells show increased sensitivity to chemotherapeutic drugs (e.g., colchicine and doxorubicin) and decreased sensitivity to collateral sensitivity drugs (e.g., verapamil and tamoxifen). Importantly, we show for the first time that down-regulation of ABCB1 expression resulting from tamoxifen treatment and CRISPR-knockout of ABCB1 expression up-regulate α-enolase (enolase I) protein levels and activity. These findings demonstrate a possible effect of ABCB1 expression on the metabolic homeostasis of MDR cells. Moreover, given the use of tamoxifen to prevent the recurrence of oestrogen receptor-positive breast cancer, the findings of this study may be clinically important in modulating activity of other drugs.
Products in Disguise: Communicating Product Benefits with Surface Mimicry
Authors: Van Kerckhove Anneleen , De Bondt Caroline , Geuens Maggie 
Published: April 2022

Abstract
In an effort to find a novel way to enhance the attractiveness of healthy food, this article proposes surface mimicry—that is, designing a product to visually resemble another product—as an effective intervention to communicate property information to consumers. Specifically, it advances the notion that exposure to surface mimicry primes property mapping, a thinking style that leads consumers to transfer property information from one product onto another. To this end, three studies show that exposure to a target food product (e.g., kiwifruit) mimicking visual characteristics of another, modifier food product (e.g., popsicle) induces a transfer of attribute values of the modifier onto the target product for salient, alignable attributes on which the products differ (e.g., tastiness). A fourth study points to the activation of a property-mapping mindset as the underlying process. Finally, the effect is shown to persist, but it attenuates when the difference in belief(s) about the target and mimicked product is substantial (e.g., the taste expectations for Brussels sprouts and popsicles).
Influence by Intimidation: Business Lobbying in the Regulatory Process
Authors: Acs Alex , Coglianese Cary 
Published: April 2022

Abstract
Interest group influence in the policy process is often theorized to occur through a mechanism of exchange, persuasion, or subsidy. Here, we explore how business groups may also exert influence by intimidating policymakers—a form of persuasion, but one based on the provision not of policy information but of political information. We develop a theory in which a business firm lobbies a regulator to communicate political information about its capacity to commit to future influence-seeking activities that would sanction the regulator. The regulator assesses the credibility of this message by evaluating the firm’s commitment to lobbying. Guided by our theory, we present empirical evidence consistent with expectations that intimidation can shape regulatory outcomes to the advantage of certain firms, both through a chilling effect, by which lobbying derails nascent regulatory plans, as well as a retreating effect, by which opposition to published proposals leads to their withdrawal.
Missplicing suppressor alleles of Arabidopsis PRE-MRNA PROCESSING FACTOR 8 increase splicing fidelity by reducing the use of novel splice sites
Authors: Cabezas-Fuster Adrián , Micol-Ponce Rosa , Fontcuberta-Cervera Sara , Ponce María Rosa 
Published: April 2022

Abstract
Efficient splicing requires a balance between high-fidelity splice-site (SS) selection and speed. In Saccharomyces cerevisiae, Pre-mRNA processing factor 8 (Prp8) helps to balance precise SS selection and rapid, efficient intron excision and exon joining. argonaute1-52 (ago1-52) and incurvata13 (icu13) are hypomorphic alleles of the Arabidopsis thaliana genes ARGONAUTE1 (AGO1) and AUXIN RESISTANT6 (AXR6) that harbor point mutations creating a novel 3′SS and 5′SS, respectively. The spliceosome recognizes these novel SSs, as well as the intact genuine SSs, producing a mixture of wild-type and aberrant mature mRNAs. Here, we characterized five novel mutant alleles of PRP8 (one of the two Arabidopsis co-orthologs of yeast Prp8), naming these alleles morphology of ago1-52 suppressed5 (mas5). In the mas5-1 background, the spliceosome preferentially recognizes the intact genuine 3′SS of ago1-52 and 5′SS of icu13. Since point mutations that damage genuine SSs make the spliceosome prone to recognizing cryptic SSs, we also tested alleles of four genes carrying damaged genuine SSs, finding that mas5-1 did not suppress their missplicing. The mas5-1 and mas5-3 mutations represent a novel class of missplicing suppressors that increase splicing fidelity by hampering the use of novel SSs, but do not alter general pre-mRNA splicing.
Response to Nivolumab and Ipilimumab in Microsatellite Instability-High (MSI-H) Cervical Carcinoma with Acquired Resistance to Pembrolizumab: A Case Report and Literature Review
Authors: Gim Gahyun , Kim Yeseul , Park Yeonggyeong , Kim Min Jeong , Nam Myungwoo , Yang Woojung , Duarte Samantha E , Jung Chan Mi , Vagia Elena , Viveiros Pedro , Chae Young Kwang 
Published: April 2022

Abstract
As the use of immune checkpoint inhibitors (ICIs) in treating a variety of cancer types has increased in recent years, so too have the number of reports on patients acquiring resistance to these therapies. Overcoming acquired resistance to immunotherapy remains an important need in the field of immuno-oncology. Herein, we present a case that suggests sequential administration of combination immunotherapy may be beneficial to advanced cervical cancer patients exhibiting acquired resistance to mono-immunotherapy. The patient’s tumor is microsatellite instability-high (MSI-H), which is an important biomarker in predicting ICI response. Results from recent interim prospective studies using combination immunotherapy (eg, nivolumab and ipilimumab) with anti-PD-1 plus anti-CTLA-4 inhibitor following progression on anti-PD-1 inhibitors (eg, nivolumab) have shown anti-tumor activity in patients with advanced melanoma and metastatic urothelial carcinoma. We also introduce retrospective studies and case reports/case series of dual checkpoint inhibition with anti-PD-1 inhibitor plus anti-CTLA-4 inhibitor after progression on prior anti-PD/PD-L1 monotherapy. To date, there has been no prospective study on the use of combined anti-PD-1 and anti-CTLA-4 therapy at the time of progression on anti-PD-1 therapy in patients with MSI-H tumors or advanced cervical cancer. In this report, we provide evidence that supports future investigations into such treatments.
Between Sisyphus’s Rock and a Warm and Fuzzy Place
Authors: Weinberg Rivka 
Published: April 2022

Abstract
This chapter suggests that there are three kinds of meaning: Everyday, Cosmic, and Ultimate. Everyday meaning refers to the value and significance in our everyday lives, including values such as beauty, morality, and truth, and the significance of engagement with them. Cosmic meaning refers to our meaningful role in the cosmos: to the significance and value of our cosmic niche, to the purposes of the cosmos and our place in it. Ultimate meaning is the end-regarding justifying reason, the valued end, or the point of leading a life at all. It is here argued that procreating can be a deep source of Everyday meaning, and perhaps Cosmic meaning. But nothing can provide us with Ultimate meaning. The implications this may have for procreative ethics is considered.
Desire and Meaning in Life
Authors: Arpaly Nomy 
Published: April 2022

Abstract
This chapter sketches a desire-based theory of meaning in life. The main thesis in question is that things that give meaning to a person’s life are things which the person desires intrinsically, even at the price of giving up considerable pleasure or taking on considerable displeasure. Such a view would encounter opposition from those who, like Susan Wolf, take meaning in life to involve not just being ‘attracted’ to something, but rather being ‘attracted’ to something which is objectively valuable. Replies are provided to this objection, taking on such examples as Wolf’s goldfish lover and Rawls’s grass counter. Finally, ways are discussed in which, given the view in question, it can be hard to find meaning in life—not only because one can’t always get what one wants, but also because one often does not know what one wants.
Suffering and Meaning in Life
Authors: Brady Michael S. 
Published: April 2022

Abstract
Suffering can have a devastating impact on individuals, and not least because it undermines or destroys many of those things which seem central to a meaningful life: personal relationships, autonomy, career, physical and psychological health, and other objects of admiration and esteem. This chapter acknowledges this point, but examines the ways in which suffering can have a positive relation to meaning in life. On the one hand, experiences of suffering can be made meaningful to those who suffer, if it is possible for the sufferer to take up a positive, virtuous attitude to their suffering. On the other hand, suffering can be an essential component in meaningful life all-things-considered. The first point will be explained through a consideration of Nietzsche’s views on suffering and psychological strength. The second will be supported by examining religious and secular perspectives on the importance of suffering for meaningful lives.
The Meaning of Life and Death
Authors: Luper Steven 
Published: April 2022

Abstract
This chapter offers an account of meaning and how it is related to welfare or well-being. Meaning and welfare are not the same thing, as some things help make life worth having without conferring meaning on it, but what gives life meaning makes it better. The account of meaning defended here is achievementism, according to which the meaning of one’s life consists in achieving the things one devotes it to. The chapter also clarifies what it is for death to have meaning. The meaning of life stands in opposition to that of death and vice versa. Other things being equal, what gives one’s life positive meaning gives one’s death negative meaning. The reverse is true as well: what gives death positive meaning gives life negative meaning.
Meaningfulness and Importance
Authors: Kahane Guy 
Published: April 2022

Abstract
Some lives are more meaningful than others. Some lives are more important than others. What is the relationship between meaning in life and importance? Because both can be described as relating to significance, the two are often conflated. But these are rather different concepts, and the meaningful and the important can easily come apart. They do, however, interact in important ways. When importance also meets the conditions for meaningfulness, it amplifies it, and importance on a large scale is a key, and perhaps the only, source of superlative meaningfulness. When contrasted with the quest for meaning, the desire for importance can seem shallow and egocentric. But the desire to make an important contribution reflects a legitimate existential concern. And, in their best form, both the desire for importance and that for meaningfulness similarly combine outward-looking and self-regarding aspects.
Paradoxes and Meaning in Life
Authors: Smilansky Saul 
Published: April 2022

Abstract
Paradoxes can be said to be the quintessence of philosophy, combining as they typically do the argument form and the radical challenge to the seemingly obvious. Like reflection about paradoxes, reflection about meaning in life goes back a long way in philosophy. Yet oddly, at least in the Western tradition, the two have hardly been combined, and certainly not to the extent that one could have imagined. The author of this chapter explores some widely known apparent paradoxes, together with some lesser known ones, that bear upon meaning in life, and draw out their significance for this topic. He looks at what it means to live with paradoxes, and concludes with some general reflections. It becomes apparent that a sophisticated, more fully aware view of human life, its absurdities, and its meaning cannot avoid the salience of paradoxes.
The Historical Roots of the Ecological Crisis
Authors: Kidwell Jeremy H. 
Published: April 2022

Abstract
This chapter analyzes the provenance and legacy of the influential article “The Historical Roots of Our Ecologic Crisis,” published in the journal Science (White 1967). It argues that White’s analysis is significantly embedded in his late-modern scholarly context and fails to transcend some embedded prejudices, not least of which is his tendency to portray religion not as a complex lived phenomenon but rather in forms that are reduced to simple binaries. It explores the modern conceptual legacy surrounding the use of “crisis” in the interpretation of historical events and documents, particularly in relation to the environment and suggests that the concept of “crisis” comes with its own intellectual baggage and cannot be invoked as a purely neutral observation. It notes several ways that the text of the Bible resists such framings, particularly given the array of other-than-human voices that convey prophetic speech. As a metaphor, “crisis” may mobilize our attentions, but it also can obscure the more complex dynamics at work in the present moment and in biblical texts. The chapter concludes by arguing that biblical hermeneutics would be well served by dispensing with the hand-wringing over “anthropocentrism” which was a hallmark of White’s generation of scholarship and instead focusing on more complex creaturely entanglements and hybrid geographies.
Ecological Hermeneutics and Postcolonialism
Authors: Masenya Madipoane 
Published: April 2022

Abstract
Informed by a holistic African worldview, one basically untouched by the impacts of foreign systems such as colonialism and apartheid in the case of South Africa, how may an African-conscious biblical scholar read the Hebrew Bible, especially Psalm 23, with ecological concerns? Due to our hybridized, globalized and mostly African-unconscious contexts, engaging in an ecologically conscious African biblical hermeneutic may appear like going up a steep cliff. However, having been nurtured by an African–South African rural setting, one in which humans basically lived in community with each other and in relative mutual interdependence with nature, one may not find it impossible to read Psalm 23, African- and nature-consciously. This chapter thus reflects one African woman’s reflections on the theme of ecological hermeneutics, particularly on the postcolonial, postapartheid African–South African space.
The Ecotheology of the Song of Songs
Authors: Bernstein Ellen 
Published: April 2022

Abstract
The Song of Songs is the most ecological text of the entire biblical canon. It expresses the biblical author’s abiding love for the land and its creatures, and asserts an indelible connection between people and earth. It implies that the beauty of nature can capture the heart and ignite one’s caring for all creation. It shuns material striving and possessiveness and reimagines the world as a vibrant garden ecosystem in which alienation is redressed, and love for ones’ beloved means love for the land and its inhabitants. It affirms that the world becomes whole when people become whole. It intimates a counternarrative to anthropocentrism, the idea that the natural world revolves around humanity. In a world threatened with ecological insecurity and societal divisiveness, the Song bridges the gap between secular and sacred, and offers a vocabulary, a story, and a vision of interdependence and wholeness that all peoples can share.
John’s Gospel
Authors: Miller Susan 
Published: April 2022

Abstract
John’s Gospel has been traditionally regarded as a “spiritual gospel,” which is concerned with the revelation of Jesus’ identity as the Messiah and Son of God. An ecological reading of the gospel, however, highlights the close identification of Jesus with the natural world. The prologue states that the world came into being through Jesus. Jesus identifies himself with the natural world in his “I am” sayings: “I am the bread of life,” “I am the light of the world,” and “I am the true vine.” This chapter argues that Jesus’ gift of eternal life is defined in terms of the abundance of the natural world. The gifts Jesus brings are linked to his death on the cross. John’s Gospel is not only concerned with the salvation of human beings. Jesus casts out the “ruler of the world” and liberates the natural world from the power of evil.
The Bible and Ecotheology
Authors: Watts Belser Julia 
Published: April 2022

Abstract
Contemporary Jewish ecotheology frequently grapples with three theological challenges that emerge from traditional readings of Genesis 1: the notion of a conflict between God and nature, the tradition of human exceptionalism, and the belief that God has granted humans dominion over the natural world. Emphasizing the multivocal nature of Jewish theology, this chapter demonstrates that biblical and rabbinic sources also offer seeds of alternative ecological possibilities: a sensuous naturalism that celebrates the wonder of creation and the kinship of all life, as well as a vibrant tradition of religious practice that allows contemporary Jews to construct ecological action as a Jewish obligation. While Jewish law has often been interpreted in ways that privileged human interests over the intrinsic value of the natural world, the chapter argues that this robust concern for human life and health can and should ground a Jewish theology and ethics of environmental justice.
“Deep Calls to Deep”
Authors: Brown William P. 
Published: April 2022

Abstract
As a collection of sung and recited poetry, the Psalter draws heavily from the natural realm for its rich storehouse of imagery. As an anthology of various theological perspectives, the Book of Psalms hosts a lively dialogue on the value and purpose of non-human creation vis-à-vis God and humanity, which proceeds from human supremacy over creation (Psalm 8) to a distinctly non-hierarchical perspective that views humanity as merely one species among many (Psalm 104). In addition, justice for creation becomes a central concern in the Psalter (Psalms 96; 98). At the Psalter’s hymnic conclusion, this unfolding dialogue reaches its glorious conclusion with a call to universal praise that re-envisions the created order and humanity’s “dominion.”
Creation Care and the Bible
Authors: Brunner Daniel L. , Swoboda A. J. 
Published: April 2022

Abstract
This chapter contends that the Scriptures must play an essential role in helping Christians—particularly evangelical Christians—engage the ecological crisis. After delineating their own “evangelical” context, the authors explore the complexities around contemporary evangelical ecological hermeneutics. The greater part of the chapter revolves around a presentation of five green hermeneutical lenses or metanarratives, each of which is biblical, Christologically focused, and attentive to the current ecological context. While the lens of stewardship remains the dominant perspective, especially among more conservative evangelicals, differences around the idea of dominion call for further green alternatives. Therefore, the chapter puts forward four additional interpretive frameworks: concern for the underprivileged, a God who both creates and redeems the cosmos, the community or interconnectedness of the whole creation, and a transformed, inaugurated eschatology. Through these lenses (evangelical) Christians can embrace Scripture with a new vitality in light of ecological realities.
Re-Viewing the Book of Jeremiah
Authors: Colgan Emily 
Published: April 2022

Abstract
The chapter begins with a brief survey of ecological scholarship relating to the book of Jeremiah, and then provides a broad overview of ecological images found within this book. It goes on to closely examine Jer 3:1–5 using a rhetorical critical methodology with an ecological hermeneutic derived from the Earth Bible tradition. It draws a connection between the female body and the fertile land, which are both identified as being polluted and must suffer punishment for this defilement. The chapter problematizes the violent and coercive relationship between God, land, and people, before outlining an alternative ecological interpretation of these verses, which understands the land as co-equal partner with God by sharing in the creative process.
The Bible and Wildlife Conservation
Authors: Bookless Dave 
Published: April 2022

Abstract
The Christian Bible, and theologies derived from it, have been accused of legitimizing the exploitation and destruction of nature. This chapter examines the textual evidence, concluding that, overall, the Bible is remarkably positive toward wildlife and encourages humanity to see wildlife as part of a theocentric moral order in which humans have responsibilities for wildlife conservation. The chapter next examines the history of Christian involvement in nature conservation, in particular the biblical inspiration of many early conservationists and animal-protectionists in Europe and North America, followed by a section looking at contemporary expressions of Christian concern for nature conservation both in writing and in practical expression. The conclusion explores possibilities for a re-engagement of faith-based conservation with the contemporary biodiversity conservation movement.