bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin-33 regulates the endoplasmic reticulum stress of human myometrium via an influx of calcium during initiation of labor
Authors: Chen Li , Song Zhenzhen , Cao Xiaowan , Fan Mingsong , Zhou Yan , Zhang Guoying 
Published: August 2022

Background:Inflammation is currently recognized as one of the major causes of premature delivery. As a member of the interleukin-1β (IL-1β) family, interleukin-33 (IL-33) has been shown to be involved in normal pregnancy as well as a variety of pregnancy-related disorder. This study aims to investigate the potential function of IL-33 in uterine smooth muscle cells during labor.Methods:Myometrium samples from term pregnant (≥37 weeks gestation) women were either frozen or cells were isolated and cultured. Immunohistochemistry and western blotting were used to assess the distribution of IL-33. Cultured cells were incubated with lipopolysaccharide (LPS) to mimic inflammation as well as in the presence of 4μ8C (IRE1 inhibitor III) to block endoplasmic reticulum (ER) stress and BAPTA-AM, a calcium chelator.Results:LPS reduced the expression of nuclear IL-33 in a time-limited manner and induced ER stress. However, knockdown of IL-33 increased LPS-induced calcium concentration, ER stress and phosphorylation of nuclear factor kappa-B (NF-κB), and P38 mitogen-activated protein kinase (P38 MAPK). In addition, siRNA IL-33 further stimulates LPS enhanced cyclooxygenase-2 (COX-2) expression via NF-κB and p38 pathways. IL-33 expression was decreased in the nucleus with the onset of labor. LPS-induced ER stress and increased expression of the labor-associated gene, COX-2, as well as IL-6 and IL-8 in cultured myometrial cells. IL-33 also increased COX-2 expression, but after it was knocked down, the stimulating effect of LPS on calcium was enhanced. 4μ8C also inhibited the expression of COX-2 markedly. The expression of calcium channels on the membrane and intracellular free calcium ion were both increased which was accompanied by phosphorylated NF-κB and p38.Conclusions:These data suggest that IL-33 may be involved in the initiation of labor by leading to stress of the ER via an influx of calcium ions in human uterine smooth muscle cells.Funding:This study was supported by grants from the National Natural Science Foundation of China (No. 81300507).
Predictability and transferability of local biodiversity environment relationships
Authors: Jung Martin 
Published: August 2022

Background
Biodiversity varies in space and time, and often in response to environmental heterogeneity. Indicators in the form of local biodiversity measures–such as species richness or abundance–are common tools to capture this variation. The rise of readily available remote sensing data has enabled the characterization of environmental heterogeneity in a globally robust and replicable manner. Based on the assumption that differences in biodiversity measures are generally related to differences in environmental heterogeneity, these data have enabled projections and extrapolations of biodiversity in space and time. However so far little work has been done on quantitatively evaluating if and how accurately local biodiversity measures can be predicted.

Methods
Here I combine estimates of biodiversity measures from terrestrial local biodiversity surveys with remotely-sensed data on environmental heterogeneity globally. I then determine through a cross-validation framework how accurately local biodiversity measures can be predicted within (“predictability”) and across similar (“transferability”) biodiversity surveys.

Results
I found that prediction errors can be substantial, with error magnitudes varying between different biodiversity measures, taxonomic groups, sampling techniques and types of environmental heterogeneity characterizations. And although errors associated with model predictability were in many cases relatively low, these results question–particular for transferability–our capability to accurately predict and project local biodiversity measures based on environmental heterogeneity. I make the case that future predictions should be evaluated based on their accuracy and inherent uncertainty, and ecological theories be tested against whether we are able to make accurate predictions from local biodiversity data.
Conventional Shaping into CNC Machine Tool Remanufacturability Assessment
Authors: Mubarak Ethar Mohammed , Ridha Ali Zuhair , Ghazi Sara Saad , Abdulrazaq Ekhlas Ahmad , Abdullah Ziyad Tariq 
Published: August 2022

Aims: Remanufacturability Index (RI) was calculated to indicate the ability of remanufacturing conventional shaping into CNC machine tool through multi-criteria assessment methodology.
Place and Duration of Study: Middle Technical University, Institute of Technology-Baghdad, Mechanical Techniques School, between 2021/2022.
Methodology: Conventional shaping machines which are remanufactured-upgraded into CNC machine tools were analyzed to classify a group of seven remanufacturing-upgrading alternatives. Multi-criteria were defined include cost, time, accuracy and complex shape, reliability, processing range and efficiency and ergonomic. Weighting of importance of criteria and performance of alternatives were conducted by applying comparative literature analysis and machine tool remanufacturing experience analysis of mechanical structure of remanufactured-upgraded conventional shaping into CNC machine tool as well as alternatives performances scoring.
Results: As many as the number of automated axes, as high as the Remanufacturability Index (RI) which is dedicated to remanufactured-upgraded conventional shaping into 2-axis to 5-axis CNC machine tool.
Conclusion: Remanufactured-upgrading conventional shaping into CNC machine tool is of high remanufacturing potentials that satisfy conditions of technical, economic and environmental feasibilities.
Prevalence and Clinical Aspects of Hemophilia in the Western Region of Cameroon
Authors: Tuono Romaric De Manfouo , Tazemda Gildas Boris Kuitsouc , Tambo Ernest , Njajou Omer 
Published: August 2022

Introduction: Hemophilia is a constitutional defect in blood clotting related to a clotting factor deficiency. Its remains a major public health problem, mainly due to ignorance of the disease, limited screening capacities and access to treatment in sub-Saharan Africa and particularly in Cameroon. It causes heavy bleeding in the absence of adequate management. Few reports are available about the disease in countries with limited resources. This study assess the occurrence of hemophilia in the Western region of Cameroon and clinical aspects with the aim of raising public awareness of the disease.
Methods: A cross-sectional and descriptive study was carried out over a period of 04 months in 5 departments of the Western region of Cameroon, in particular Mifi, Ndé, Bamboutos, Haut Nkam and Menoua. The individuals were selected in their houses on the basis of clinical arguments, i.e. bleeding from the gums, traumatic wounds, hematomas. The blood samples taken from the latter were analyzed in the hemostasis laboratory of the Regional Hospital of Bafoussam. The epidemiological characteristics of hemophiliacs identified and suspects hemophiliacs were analyzed. The results obtained were analysed using statistical software R version 4.1.1.
Results: Out of 5995 people selected, 13 (0.22%) cases of hemophilia were identified, 09 confirmed cases and 04 new cases. The mean age of the patients was 14.85 years old (1.5-49). The disease was discovered mainly during circumcision in the months following birth (9/13, 69.23%), and by bleeding of the gums (9/13, 69.23%). Clinical signs were pain of the joints (46%), hematoma and swelling of the joints (38%). Platelets counts and prothrombin rate were normal in all. However, a prolonged Cephalin + Activator Time was found; it was corrected by supplying normal control plasma.
Conclusion: Hemophilia is a pathology little known for the general public. For this, with the help of public authorithies, continuing education sessions must be set up to raise awareness among the population in order to limit the transmission of the disease and to eradicate this scourge which constitutes a real public health problem.
DO “MUNDINHO”FECHADO AO UNIVERSO QUASE INFINITO: negociando a saída de casa
Authors: Lins Myriam Moraes 
Published: August 2022

Este texto tem como objetivo a análise das transformações nas trajetórias de vida de jovens universitárias, e de suas famílias, que representam a primeira geração da família a entrar para a universidade. Esta análise é um dos resultados da pesquisa comparativa sobre os projetos de vida e as relações intergeracionais de estudantes dos cursos de Comunicação Social, Serviço Social e Letras da UFRJ. A interpretação das próprias experiências de vida mostra a valorização de projetos individuais autônomos pelas jovens mulheres entrevistadas. A autonomia, entretanto, não anula a importância da família, sobretudo da mãe, na realização dos projetos. Ocorre uma constante negociação entre pais e filhas, e a influência da família é relativizada pela abertura da rede de sociabilidade para essas universitárias. Palavras-Chave: projeto de vida, juventude, família, gerações, universidade. FROM THE CLOSED “WORLD” TO THE ALMOST INFINITE UNIVERSE: negotiating a way out from home In this article the author analyses life trajectories of undergraduate young women and their families, using the database of a comparative research about life projects and intergeneration relationships of students from the graduate courses of social communication, social service and languages of the Federal University of Rio de Janeiro. These students are the first members of their families to enter university. The students’ interpretation of their own life experiences shows a strong valorization of their individual and autonomous projects. This autonomy, however, doesn’t nullify the importance of their family, and, above all, of their mothers. Negotiation between parents and daughters is a constant, and the family influence is minimized only by the gradual opening of the network of sociability for these new undergraduate young women. Key Words: life project, youth, family, generation, university. D’UN “PETIT MONDE” FERMÉ À UN UNIVERS PRESQUE INFINI: négociation pour sortir de chez soi L’objectif de cet article est d’analyser les transformations de la trajectoire des jeunes étudiantes universitaires et de leur famille, sachant qu’il s’agit de la première génération de la famille à s’inscrire à l’université. Cette étude présente les résultats d’une recherche comparative sur les projets de vie et les relations entre générations d’étudiantes en Communication Sociale, Lettres et Service Social (travailleur social) de l’Université Fédérale de Rio de Janeiro - UFRJ. L’interprétation de leurs expériences de vie montre que ces jeunes femmes donnent de la valeur aux projets individuels autonomes. Par ailleurs, cette autonomie n’annule pas l’importance de la famille, et surtout de la mère, dans la réalisation de ces projets. Il y a donc une négociation constante entre les parents et leurs filles et l’influence de la famille devient relative étant donné l’ouverture d’un nouveau réseau de sociabilité pour ces étudiantes universitaires. Mots-Clés: projet de vie, jeunesse, famille, générations, université. Publicação Online do Caderno CRH: http://www.cadernocrh.ufba.br
HABLEMOS DEL DELITO: la compleja relación entre el orden normativo y la realidad social
Authors: Pegoraro Juan S. 
Published: August 2022

O artigo aborda a questão da ordem social e das práticas ilegais como uma realidade observável e constitutiva das relações sociais que definem esta ordem. Propõe que a visão da sociologia sobre a “sociedade” é insuficiente e ocultadora da realidade existente. Mesmo quando as ações sociais assumem formas cooperativas ou organizadas, estas não são incompatíveis com a existência de práticas ilegais que repercutem na estrutura social e afetam as relações de dominação política e econômica. Em resumo, ao contrário do que pensam muitos teóricos, as práticas ilegais contribuem para a constituição e reprodução da ordem social. PALAVRAS-CHAVE: ordem social, normas, ação social, práticas ilegais, dominação.LET’S TALK ABOUT THE FELONY – the complex relationship between normative order and social reality Juan S.Pegoraro This paper approaches the issue of social order and illegal practices as an observable reality constituting the social relations defining this social order. It proposes that sociology’s vision of society is insufficient and hides existing reality.Even when social actions take cooperative or organized shapes, they are not incompatible with the existence of illegal practices that affect the social structure and affect the political and economic dominance relations. Summing up, contrary to many thoretician’s thoughts, illegal practices help the reproduction and constitution of the social order. KEYWORDS: social order, rules, social actions, illegal practices, domination.PARLONS DU DÉLIT – la relation complexe entre l’ordre normatif et la réalité sociale Juan S.Pegoraro Cet article traite de l’ordre social et des pratiques illégales en tant que réalité observable et constitutive des relations sociales qui sont à la base de cet ordre. On y estime que le regard de la sociologie sur la “société” est insuffisant et masque la réalité existante. Même lorsque les actions sociales prennent des formes coopératives ou organisées, elles ne sont pas incompatibles avec l’existence de pratiques illégales ayant des répercussions sur la structure sociale et une influence sur les relations de domination politique et économique. En synthèse, contrairement à ce que pensent de nombreux théoriciens, les pratiques illégales ont une influence sur la constitution et la reproduction de l’ordre social. MOTS-CLÉS: ordre social, normes, règles, pratiques illégales, domination.Publicação Online do Caderno CRH no Scielo: http://www.scielo.br/ccrh Publicação Online do Caderno CRH: http://www.cadernocrh.ufba.br
A ANTROPOLOGIA EM XEQUE: em busca de um novo olhar antropológico
Authors: Trigueiro Aline 
Published: August 2022

Através da recuperação de textos de vários autores, este artigo objetiva refletir sobre os atuais rumos da prática antropológica frente às transformações do mundo contemporâneo. Trata-se, na verdade, de explorar quais os dilemas e as nova perspectivas que estão sendo produzidos na tentativa de aproximar o “ofício do antropólogo” de um mundo que se transforma. Tentaremos identificar, ainda, como as mudanças no cenário mundial – descolonização, globalização – podem ser capazes de abrir outras possibilidades para que as diferenças culturais sejam interpretadas. Além disso, temos a intenção de traçar um panorama da prática antropológica na atualidade, apontando as principais tensões enfrentadas pela mesma, sobretudo, no quesito como compreender “o outro” e a sua cultura? PALAVRAS-CHAVE: olhar antropológico, globalização, etnocentrismo, modernidade, pós-modernidade.THE ANTHROPOLOGY IN CHECK: in search of a new anthropological point of view Aline Trigueiro Through the analysis of texts by many authors, this paper intends to discuss the current directions of the anthropological practice regarding the transformations of the contemporary world. It is about, actually, exploring which dilemmas and new perspectives are being produced in the attempt to approximate the “anthropologist’s living” to a changing world. We will also try to identify how changes in the world scenery – descolonization, globalization – can open other possibilities to interpret cultural differences. Besides, we intend to draw a panorama of the current anthropological practice, pointing the main tensions it faces, specially, in the issue of understanding “the other” and their culture? KEYWORDS: anthropological point of view, globalization, ethnocentrism, modernity, post-modernity.L’ANTHROPOLOGIE EN ÉCHEC: a la recherche d’un nouveau regard anthropologique Aline Trigueiro Par l’analyse de textes de plusieurs auteurs, cet article se veut d’être une réflexion sur les tendances actuelles de la pratique anthropologique face aux transformations du monde contemporain. Il s’agit plus exactement d’explorer les dilemmes et les nouvelles perspectives produits pour essayer de rapprocher “le travail de l’anthropologue” d’un monde qui se transforme. Nous essayons aussi d’identifier comment les changements qui ont lieu sur la scène mondiale – décolonisation, mondialisation – sont capables d’ouvrir de nouvelles perspectives pour que les différences culturelles puissent être interprétées. De plus, notre intention est de tracer un panorama de la pratique anthropologique dans l’actualité, en montrant les principales tensions qu’elle affronte, surtout quant à la question de comprendre “l’autre” et sa culture. MOTS-CLÉS: regard anthropologique, mondialisation, ethnocentrisme, modernité, post-modernité.Publicação Online do Caderno CRH:http://www.cadernocrh.ufba.br
Políticas e Guerras da cultura: filtros de investimento público como "pós-censura"
Authors: Paula Leandro de , Dumas Caroline , Pimenta Fernanda 
Published: August 2022

Este artigo investiga a relação entre o ambiente de "guerra cultural" no Brasil e o regime de moderação de liberdades expressivas conhecido como "pós-censura", analisando como os dois fenômenos se interligam na gestão de fundos públicos de incentivo à cultura pelo governo Bolsonaro. Reconstituímos os desdobramentos jurídicos e políticos de três medidas da Secretaria Especial de Cultura entre 2019 e 2021: a suspensão de um edital para TVs públicas; a inabilitação do Instituto Vladimir Herzog para captação de recursos; e a paralisação da análise de projetos previstos para cidades que adotassem ações de lockdown . Decisões judiciais, notas de órgãos de governo, material de imprensa e de redes sociais compõem o corpus, examinado sob as premissas da análise de controvérsias públicas.
Sleep Disorders Among Individuals With Rheumatoid Arthritis
Authors: Katz Patricia , Pedro Sofia , Michaud Kaleb 
Published: August 2022

ObjectiveSelf‐reported sleep problems are common in rheumatoid arthritis (RA), with potential negative health implications, yet relatively little research has focused on sleep in RA. We examined the prevalence of obstructive sleep apnea (OSA) risk, restless legs syndrome (RLS) symptoms, and short sleep (SS) in a large RA cohort (n = 4,200) and factors associated with each.MethodsData are from FORWARD, The National Databank for Rheumatic Diseases. Validated screening measures assessed OSA risk and RLS symptoms. SS was based on self‐reported average sleep time (<6 hours). The Medical Outcomes Study Sleep Problems Index I measured self‐reported sleep quality. Multivariable logistic regression models identified independent predictors of sleep disorders and sleep quality and the independent association of OSA risk, RLS symptoms, and SS with self‐reported poor sleep quality.ResultsTwenty‐one percent (n = 899) had OSA diagnosis or risk, 30% (n = 1,272) had RLS symptoms or diagnosis, and 43% (n = 1,737) reported SS, and RA disease activity was associated with each sleep disorder. Abatacept use was associated with lower odds of RLS and SS. Use of conventional disease‐modifying antirheumatic drugs or abatacept was less frequent in the SS group. No medications were associated with OSA in multivariable analyses. Both RLS and SS was associated with worse perceived sleep quality.DiscussionAlmost two‐thirds met criteria for at least one sleep disorder. RA disease activity and pain were significantly associated with each sleep condition. Additional research is needed to identify the causal pathway between sleep disorders and RA disease activity and pain and the long‐term consequences of sleep disorders in RA.
Training‐on‐a‐Chip: A Multi‐Organ Device to Study the Effect of Muscle Exercise on Insulin Secretion in Vitro
Authors: Fernández‐Costa Juan M. , Ortega María A. , Rodríguez‐Comas Júlia , Lopez‐Muñoz Gerardo , Yeste Jose , Mangas‐Florencio Lluís , Fernández‐González Miriam , Martin‐Lasierra Eduard , Tejedera‐Villafranca Ainoa , Ramon‐Azcon Javier 
Published: August 2022

AbstractOrgan‐on‐a‐chip (OOC) devices bring innovative disease modeling and drug discovery approaches by providing biomimetic models of tissues and organs in vitro combined with biosensors. Miniaturized biosensor systems and tissue biofabrication techniques allow to create multiple tissues on a chip highly controlling the experimental variables for high‐content screening applications. In this work, a biomimetic multi‐OOC integrated platform composed of skeletal muscle and pancreatic cells is fabricated to study the impact of exercise on insulin secretion. Both engineered tissues are integrated with optical biosensing technology to monitor in real‐time the contraction‐induced myokine secretion and their effect on beta‐cells insulin production. Using this device, it is demonstrated that insulin secretion is induced directly by the effect of myotubes contractions. The cross‐talk platform would improve drug assays and provide a new model to study the loss of pancreas functionality associated with diabetes mellitus.
White matter hyperintensities in former American football players
Authors: Alosco Michael L. , Tripodis Yorghos , Baucom Zachary H. , Adler Charles H. , Balcer Laura J. , Bernick Charles , Mariani Megan L. , Au Rhoda , Banks Sarah J. , Barr William B. , Wethe Jennifer V. , Cantu Robert C. , Coleman Michael J. , Dodick David W. , McClean Michael D. , McKee Ann C. , Mez Jesse , Palmisano Joseph N. , Martin Brett , Hartlage Kaitlin , Lin Alexander P. , Koerte Inga K. , Cummings Jeffrey L. , Reiman Eric M. , Stern Robert A. , Shenton Martha E. , Bouix Sylvain ,   for the DIAGNOSE CTE Research Project
Published: August 2022

AbstractIntroductionThe presentation, risk factors, and etiologies of white matter hyperintensities (WMH) in people exposed to repetitive head impacts are unknown. We examined the burden and distribution of WMH, and their association with years of play, age of first exposure, and clinical function in former American football players.MethodsA total of 149 former football players and 53 asymptomatic unexposed participants (all men, 45–74 years) completed fluid‐attenuated inversion recovery magnetic resonance imaging, neuropsychological testing, and self‐report neuropsychiatric measures. Lesion Segmentation Toolbox estimated WMH. Analyses were performed in the total sample and stratified by age 60.ResultsIn older but not younger participants, former football players had greater total, frontal, temporal, and parietal log‐WMH compared to asymptomatic unexposed men. In older but not younger former football players, greater log‐WMH was associated with younger age of first exposure to football and worse executive function.DiscussionIn older former football players, WMH may have unique presentations, risk factors, and etiologies.HighlightsOlder but not younger former football players had greater total, frontal, temporal, and parietal lobe white matter hyperintensities (WMH) compared to same‐age asymptomatic unexposed men.Younger age of first exposure to football was associated with greater WMH in older but not younger former American football players.In former football players, greater WMH was associated with worse executive function and verbal memory.