bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing non-thermal equilibrium contact binaries
Authors: Wang Z H , Zhu L Y , Yuan K 
Published: September 2022

ABSTRACT
Formation and evolution of marginal contact binaries with larger temperature difference between their two components remain inexplicable to date. To get a better understanding of the nature of such population we investigate on an individual, NSVS 7358116, by analysing observational data obtained from ground-based and space-based telescopes. It is found that NSVS 7358116 is a marginal contact totally eclipsing binary with a small fill-out factor by 3 per cent but large temperature difference by 2000 K or t-ratio by 0.3. This suggests that its two components are in poor thermal contact. By collecting all available targets in literature, we compiled a table of 80 non-thermal equilibrium contact binaries (nTCBs) including 39 STRONG t-ratio samples and 41 WEAK t-ratio samples. We performed statistical distribution analysis on physical parameters which reveals that STRONG t-ratio samples will evolve to WEAK t-ratio samples through heat and mass transfer along with angular momentum loss, meanwhile thickening their common envelop. This current investigation is acted as only an appetizer, because more exploration on nTCBs and its evolutionary connection with related populations will follow.
MRI turbulence in accretion discs at large magnetic Prandtl numbers
Authors: Held Loren E , Mamatsashvili George 
Published: September 2022

ABSTRACT
The effect of large magnetic Prandtl number Pm (the ratio of viscosity to resistivity) on the turbulent transport and energetics of the magnetorotational instability (MRI) is poorly understood, despite the realization of this regime in astrophysical environments as disparate as discs from binary neutron star (BNS) mergers, the inner regions of low-mass X-ray binaries and active galactic nuclei, and the interiors of protoneutron stars. We investigate the MRI dynamo and associated turbulence in the regime Pm &gt; 1 by carrying out fully compressible, 3D MHD-shearing box simulations using the finite-volume code pluto, focusing mostly on the case of Keplerian shear relevant to accretion discs. We find that when the magnetic Reynolds number is kept fixed, the turbulent transport (as parameterized by α, the ratio of stress to thermal pressure) scales with the magnetic Prandtl number as α ∼ Pmδ, with δ ∼ 0.5−0.7 up to Pm ∼ 128. However, this scaling weakens as the magnetic Reynolds number is increased. Importantly, compared to previous studies, we find a new effect at very large Pm – the turbulent energy and stress begin to plateau, no longer depending on Pm. To understand these results we have carried out a detailed analysis of the turbulent dynamics in Fourier space, focusing on the effect of increasing Pm on the transverse cascade – a key non-linear process induced by the disc shear flow that is responsible for the sustenance of MRI turbulence. Finally, we find that α–Pm scaling is sensitive to the box vertical-to-radial aspect ratio, as well as to the background shear.
Equation of state for hot hyperonic neutron star matter
Authors: Kochankovski Hristijan , Ramos Angels , Tolos Laura 
Published: September 2022

Abstract
The FSU2H equation-of-state model, originally developed to describe cold neutron star matter with hyperonic cores, is extended to finite temperature. Results are presented for a wide range of temperatures and lepton fractions, which cover the conditions met in protoneutron star matter, neutron star mergers, and supernova explosions. It is found that the temperature effects on the thermodynamical observables and the composition of the neutron star core are stronger when the hyperonic degrees of freedom are considered. An evaluation of the temperature and density dependence of the thermal index leads to the observation that the so-called Γ law, widely used in neutron star merger simulations, is not appropriate to reproduce the true thermal effects, specially when hyperons start to be abundant in the neutron star core. To make finite temperature equations of state easily accessible, simple parametrizations of the thermal index for nucleonic and hyperonic β-stable neutrino-free matter are provided.
EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma
Authors: Showpnil Iftekhar A , Selich-Anderson Julia , Taslim Cenny , Boone Megann A , Crow Jesse C , Theisen Emily R , Lessnick Stephen L 
Published: September 2022

Abstract
Ewing sarcoma is a prototypical fusion transcription factor-associated pediatric cancer that expresses EWS/FLI or a highly related FET/ETS chimera. EWS/FLI dysregulates transcription to induce and maintain sarcomagenesis, but the mechanisms utilized are not fully understood. We therefore sought to define the global effects of EWS/FLI on chromatin conformation and transcription in Ewing sarcoma cells using a well-validated ‘knock-down/rescue’ model of EWS/FLI function in combination with next generation sequencing assays to evaluate how the chromatin landscape changes with loss, and recovery, of EWS/FLI expression. We found that EWS/FLI (and EWS/ERG) genomic localization is largely conserved across multiple patient-derived Ewing sarcoma cell lines. This EWS/FLI binding signature is associated with establishment of topologically-associated domain (TAD) boundaries, compartment activation, enhancer-promoter looping that involve both intra- and inter-TAD interactions, and gene activation. In addition, EWS/FLI co-localizes with the loop-extrusion factor cohesin to promote chromatin loops and TAD boundaries. Importantly, local chromatin features provide the basis for transcriptional heterogeneity in regulation of direct EWS/FLI target genes across different Ewing sarcoma cell lines. These data demonstrate a key role of EWS/FLI in mediating genome-wide changes in chromatin configuration and support the notion that fusion transcription factors serve as master regulators of three-dimensional reprogramming of chromatin.
Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding
Authors: Hyjek-Składanowska Malwina , Anderson Brooke A , Mykhaylyk Vitaliy , Orr Christian , Wagner Armin , Poznański Jarosław T , Skowronek Krzysztof , Seth Punit , Nowotny Marcin 
Published: September 2022

AbstractThe introduction of phosphorothioate (PS) linkages to the backbone of therapeutic nucleic acids substantially increases their stability and potency. It also affects their interactions with cellular proteins, but the molecular mechanisms that underlie this effect are poorly understood. Here, we report structural and biochemical studies of interactions between annexin A2, a protein that does not possess any known canonical DNA binding domains, and phosphorothioate-modified antisense oligonucleotides. We show that a unique mode of hydrophobic interactions between a sulfur atom of the phosphorothioate group and lysine and arginine residues account for the enhanced affinity of modified nucleic acid for the protein. Our results demonstrate that this mechanism of interaction is observed not only for nucleic acid-binding proteins but can also account for the association of PS oligonucleotides with other proteins. Using the anomalous diffraction of sulfur, we showed that preference for phosphorothioate stereoisomers is determined by the hydrophobic environment around the PS linkage that comes not only from protein but also from additional structural features within the ASO such as 5-Me groups on cytosine nucleobases.
Predicting Risk of Multidrug-Resistant Enterobacterales Infections Among People With HIV
Authors: Henderson Heather I , Napravnik Sonia , Kosorok Michael R , Gower Emily W , Kinlaw Alan C , Aiello Allison E , Williams Billy , Wohl David A , van Duin David 
Published: September 2022

AbstractBackgroundMedically vulnerable individuals are at increased risk of acquiring multidrug-resistant Enterobacterales (MDR-E) infections. People with HIV (PWH) experience a greater burden of comorbidities and may be more susceptible to MDR-E due to HIV-specific factors.MethodsWe performed an observational study of PWH participating in an HIV clinical cohort and engaged in care at a tertiary care center in the Southeastern United States from 2000 to 2018. We evaluated demographic and clinical predictors of MDR-E by estimating prevalence ratios (PRs) and employing machine learning classification algorithms. In addition, we created a predictive model to estimate risk of MDR-E among PWH using a machine learning approach.ResultsAmong 4734 study participants, MDR-E was isolated from 1.6% (95% CI, 1.2%–2.1%). In unadjusted analyses, MDR-E was strongly associated with nadir CD4 cell count ≤200 cells/mm3 (PR, 4.0; 95% CI, 2.3–7.4), history of an AIDS-defining clinical condition (PR, 3.7; 95% CI, 2.3–6.2), and hospital admission in the prior 12 months (PR, 5.0; 95% CI, 3.2–7.9). With all variables included in machine learning algorithms, the most important clinical predictors of MDR-E were hospitalization, history of renal disease, history of an AIDS-defining clinical condition, CD4 cell count nadir ≤200 cells/mm3, and current CD4 cell count 201–500 cells/mm3. Female gender was the most important demographic predictor.ConclusionsPWH are at risk for MDR-E infection due to HIV-specific factors, in addition to established risk factors. Early HIV diagnosis, linkage to care, and antiretroviral therapy to prevent immunosuppression, comorbidities, and coinfections protect against antimicrobial-resistant bacterial infections.
Roman Catholic Theology
Authors: Phan Peter C. 
Published: September 2022

Abstract
Although the Roman Catholic Church claims historical continuity with Jesus Christ himself and regards the subsequent Christian development as its own, it acquired distinctive features in matters of doctrine, worship, ethics, spirituality, and organization since the Reformation in opposition to the Protestant churches (and to a lesser extent also to the Orthodox church since 1054). “Roman Catholic theology” refers to the doctrinal development that has taken place in the Roman Catholic Church from the sixteenth century (commonly referred to as the Counter-Reformation) until today. Since it is characteristic of Roman Catholic theology to accord a special authority to the official teachings of the church (the magisterium), especially of ecumenical councils and bishops (in particular the bishop of Rome and his immediate collaborators), this article begins with an exposition of the magisterium's teaching on eschatology. Next, it expounds the eschatology of some of the most influential contemporary Roman Catholic theologians such as Karl Rahner, Hans Urs von Balthasar, Ladislaus Boros, Edward Schillebeeckx, and Joseph Ratzinger. It also discusses Catholic official teachings on eternal life and contemporary Catholic eschatologies.
Process Eschatology
Authors: Griffin David Ray 
Published: September 2022

Abstract
This article discusses eschatology from the perspective of process theology, a theological movement that employs the “process philosophy” of Alfred North Whitehead and Charles Hartshorne. It considers the question of whether process theology can do justice to the basic dimensions of the eschatology of Jesus Christ. Salvation for Jesus involved four dimensions: salvation from the threat of meaninglessness through confidence that we are known and loved by our Creator; an ultimate salvation in a resurrected life beyond bodily death; a salvation that would be realized on earth with the coming political reign of God; and a reign of God in the individual heart and in social relations (which is made possible by faith in the first three dimensions of salvation). Modern liberal theology has generally denied the second and third dimensions and sometimes even the first, thereby leaving the fourth dimension—often called “realized eschatology”—with little, if any, basis. This article also examines subjective immortality and sanctification in a life beyond bodily death.
Liberation Theology: A Latitudinal Perspective
Authors: Westhelle Vítor 
Published: September 2022

Abstract
Liberation theology (LT) is a plural concept but a catalytic notion for theologies that challenge the hegemonic theological canon. Hegemony is a concept borrowed by LT from Italian philosopher Antonio Gramsci. It designates a certain ruling order that combines power and consent. Liberation theologies can be broadly defined as an indisposition toward the hegemonic canons of Western theology. In this sense, they manifest in an array of theological expressions which include along with third world theologies, North American black theology, feminist theology, womanist theology, and many other adjectival or genitive theologies that challenge the dominant Western academic theological productions. This article discusses LT from a latitudinal perspective, eschatology and paradigms for eschatological thinking, Christianity and post-colonialism, the incoming reign of God and the signs of places, and eschaton.
Death, Final Judgment, and the Meaning of Life
Authors: Hart David Bentley 
Published: September 2022

Abstract
The ancient injunction memento mori—whispered by a slave into the ear of a victorious general in his triumphal chariot or by a monk to his own heart in the solitude of his cell—has frequently been translated as “remember that thou art mortal,” which may be faithful to the phrase's special hortatory import; but the literal meaning of the injunction is “remember to die.” However, we cannot easily remember to die because death runs contrary to the whole orientation of human consciousness. In Christian thought sacrifice and judgment, life from death, and the life of the age to come converge in a way that radically transforms them. Indeed, one might even say that, on the cross of Christ, two distinct orders of sacrifice uniquely coincide and that at Easter one order triumphs completely over the other. This article discusses death, final judgment, and the meaning of life. It examines religion and meaning without an afterlife, the reorientation of religious consciousness, and the radical transformation of judgment in light of Easter.
Time, Eternity, and Eschatology
Authors: Craig William Lane 
Published: September 2022

Abstract
Time is that dimension of reality whose constituent elements are ordered by relations of “earlier than,” “simultaneous with,” and “later than”, and are experienced by us as past, present, and future. This much, at least, is common property among almost all disputants in debates about the nature of time. Beyond that point, philosophers are deeply divided about the nature of time. The controversy most relevant to the concerns of eschatology is the debate over whether time is tensed or tenseless. We are all familiar with tense as it plays a role in natural languages. Philosophers and theologians are also deeply divided over the nature of divine eternity, debating whether God's eternity is to be construed as a state of timelessness or of infinite, omnitemporal duration. Theories of time intersect crucially with theories of divine eternity and with cosmogony. This is also the case with eschatology, in particular with physical eschatology. This article explores the interface of time, eternity, and eschatology and discusses perdurantism.
Holographic index calculation for Argyres–Douglas and Minahan–Nemeschansky theories
Authors: Imamura Yosuke , Murayama Shuichi 
Published: September 2022

Abstract
We calculate the superconformal indices of the $\mathcal {N}=2$ superconformal field theories realized on N coincident D3-branes in 7-brane backgrounds with constant axiodilaton via the anti-de Sitter/conformal field theory correspondence. We include the finite-N corrections as the contribution of D3-branes wrapped around 3-cycles in the internal space. We take only single-wrapping contributions into account for simplicity. We also determine the orders of the next-to-leading corrections that we do not calculate. The orders are relatively high, and we obtain many trustworthy terms. We give the results for N = 1, 2, 3 explicitly, and find nice agreement with known results.
Response of the underground environment of the KAGRA observatory against the air pressure disturbance from the Tonga volcanic eruption on January 15, 2022
Authors: Washimi Tatsuki , Yokozawa Takaaki , Takamori Akiteru , Araya Akito , Hoshino Sota , Itoh Yousuke , Kobayashi Yuichiro , Kume Jun’ya , Miyo Kouseki , Ohkawa Masashi , Oshino Shoichi , Tomaru Takayuki , Yokoyama Jun’ichi , Yuzurihara Hirotaka 
Published: September 2022

Abstract
On January 15, 2022, at 04:14:45 (UTC), the Hunga Tonga-Funga Ha’apai, a submarine volcano in the Tongan archipelago in the southern Pacific Ocean, erupted and generated global seismic, shock, and electromagnetic waves, which also reached Japan, situated more than 8000 km away. KAGRA is a gravitational wave telescope located in an underground facility in Kamioka, Japan. It has a wide variety of auxiliary sensors to monitor environmental disturbances that obstruct the observation of gravitational waves. The effects of the volcanic eruption were observed by these environmental sensors both inside and outside of the underground facility. In particular, the shock waves made it possible to evaluate the transfer functions from the air pressure wave in the atmosphere to the underground environmental disturbances (air pressure and seismic motion).
Patient Perspectives after Trapeziectomy and Ligament Reconstruction Tendon Interposition: A Qualitative Analysis
Authors: Stepan Jeffrey G. , Rolf Liz , Zhu Eric , Brody Madison , Landau Andrew J. , Calfee Ryan P. , Dy Christopher J. 
Published: September 2022

Background:
We aimed to explore patients’ perioperative experience after trapeziectomy and ligament reconstruction tendon interposition (LRTI) through semi-structured patient interviews to identify deficiencies in our preoperative patient counseling.

Methods:
We conducted semi-structured interviews with 14 patients who had undergone LRTI either 10-14 weeks or 9-12 months post-op at the time of their interview. The semi-structured interview guide was developed by a fellowship-trained hand surgeon and a qualitative research specialist to discuss each patient’s perioperative experience. Inductive and deductive qualitative coding strategies were used to develop a codebook. All transcripts were then double coded and discussed to develop recurrent major themes from the patient interviews.

Results:
Our interviews identified three major themes discussed consistently on the patient perioperative experience. 1) Despite specific counseling about a 3-6 month postoperative rehabilitation period, patients were still surprised at the length of recovery process in regaining function, range of motion, and strength. 2) Patients repeatedly outlined that surgery on the dominant hand imparted specific limitations that made the postoperative course difficult. 3) Patients discussed the importance of hand therapy both in rehabilitation and guiding patient postoperative expectations.

Conclusions:
Preoperative counseling is of vital importance to set patient expectations in terms of overall expected outcomes, but also regarding early limitations, expectations, and overall recovery length. These themes have influenced how we counsel our patients about recovery after thumb CMC surgery and may help other surgeons identify areas for improvement in their discussions with patients.
Adaptive compensation of arcuate fasciculus lateralization in developmental dyslexia
Authors: Zhao Jingjing , Zhao Yueye , Song Zujun , de Schotten Michel Thiebaut , Altarelli Irene , Ramus Franck 
Published: September 2022

AbstractPrevious studies have reported anomalies in the arcuate fasciculus (AF) lateralization in developmental dyslexia (DD). Still, the relationship between AF lateralization and literacy skills in DD remains largely unknown. The purpose of our study is to investigate the relationship between the lateralization of the AF anterior segment (AFAS), AF long segment (AFLS), and AF posterior segment (AFPS) in connection to literacy skills in DD. The participants included 26 children with dyslexia and 31 age-matched children in the control group. High angular diffusion imaging, combined with spherical deconvolution tractography, was used to reconstruct the AF. Connectivity measures of hindrance-modulated oriented anisotropy (HMOA) were computed for each of the three segments of the AF: anterior segment (AFAS), long segment (AFLS), and posterior segment (AFPS). The lateralization index (LI) of each AF segment was calculated by (right HMOA - left HMOA) / (right HMOA + left HMOA). Results showed that the LIs of AFAS and AFLS were positively correlated with reading accuracy in children with dyslexia. Specifically, the LI of AFAS was positively correlated with text and nonword reading accuracy, while the LI of AFLS accounted for word reading accuracy. The results suggest adaptive compensation of arcuate fasciculus lateralization in developmental dyslexia and functional dissociation of the anterior segment and long segment in the compensation.
Additional Evidence Implicating GPD1L in the Pathogenesis of Brugada Syndrome in A Large Multi-generational Family
Authors: Greiner Alexander , Mehdi Haider , Cevan Chloe , Gutmann Rebecca , London Barry 
Published: September 2022

AbstractBackgroundBrugada Syndrome (BrS) is an inherited arrhythmia syndrome in which mutations in SCN5A account for 20% of cases. Mutations in other ion channels or channel-modifying genes may account for an additional 10% of cases, though recent analysis has suggested that SCN5A should be regarded as the sole monogenic cause of BrS.ObjectiveWe sought to re-assess the genetic underpinnings of BrS in a large mutligenerational family with a putative GPD1L-A280V mutation.MethodsFine linkage mapping was performed in the family using the Illumina Global Screening array. Whole exome sequencing of the proband was performed to identify rare variants and mutations, and Sanger sequencing was used to assay previously-reported risk single nucleotide polymorphsims (SNPs) for BrS.ResultsLinkage analysis decreased the size of the previously-reported microsatellite linkage region to ∼3 megabases. GPD1L-A280V was the only rare coding non-synonymous variation present at <1% allele frequency in the proband within the linkage region. Other variants were either synonymous, or in genes not known to play a role in BrS and that failed to co-segregate with BrS in the large family. Risk SNPs known to predispose to BrS were overrepresented in affected members of the family.ConclusionTogether, our linkage and sequencing data suggest GPD1L-A280V remains the most likely cause of BrS in this large mutligenerational family. While care should be taken in interpreting variant pathogenicity given the genetic uncertainty of BrS, our data support inclusion of other putative BrS in clinical genetic panels.