bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social housing status impacts rhesus monkeys’ affective responding in classic threat processing tasks
Authors: Charbonneau Joey A. , Amaral David G. , Bliss-Moreau Eliza 
Published: March 2022

AbstractIndividuals’ social contexts are broadly recognized to impact both their psychology and neurobiology. These effects are observed in people and in nonhuman animals who are the subjects for comparative and translational science. The social contexts in which monkeys are reared have long been recognized to have significant impacts on affective processing. Yet, the social contexts in which monkeys live as adults are often ignored and could have important consequences for interpreting findings, particularly those related to biopsychiatry and behavioral neuroscience studies. The extant nonhuman primate neuropsychological literature has historically tested individually-housed monkeys, creating a critical need to understand how social context might impact the outcomes of such experiments. We evaluated affective responding in adult rhesus monkeys living in four different social contexts using two classic threat processing tasks—a test of responsivity to objects and a test of responsivity to an unfamiliar human. These tasks have been commonly used in behavioral neuroscience for decades. Relative to monkeys with full access to a social partner, individually-housed monkeys had blunted reactivity to threat and monkeys who had limited contact with their partner were more reactive to some threatening stimuli. These results indicate that monkeys’ social housing contexts impact affective reactivity and point to the potential need to reconsider inferences drawn from prior studies in which the impacts of social context have not been considered.
Chronological expression and distribution of African swine fever virus p30 and p72 proteins in experimentally infected pigs
Authors: Oh Taehwan , Do Duy Tien , Lai Danh Cong , Nguyen Lan Thi , Lee Joo Young , Van Le Phan , Chae Chanhee 
Published: March 2022

AbstractAfrican swine fever virus (ASFV), the causative agent of contagious hemorrhagic disease in domestic pigs and wild boars, has temporally regulated gene expression kinetics. The p30 and p72 major structural proteins are involved in viral entry each with different expression kinetics, but neither of their chronological expressions and distribution have been identified in virus-infected animals. Here, we found that both transcription and translation levels of p30 were significantly higher than those of p72 in target organs during the earlier infection-phase. Lymphocyte apoptosis/necrosis and angiectasia were observed as signs of early infection with acute African swine fever. These results show that the chronologically differential expression of ASFV structural proteins tends to be prominent in infected animals, and the p30 protein could play a role in the indication of acute lesions during early infection compared to the late-expressed p72 protein. In conclusion, we propose to consider the chronological expression dynamics of ASFV structural proteins in infected animals to understand virus pathogenesis and antigen targeting for vaccine development.
New insights into the micromixer with Cantor fractal obstacles through genetic algorithm
Authors: Chen Xueye , Lv Honglin 
Published: March 2022

AbstractThis work is mainly to combine fractal principle with multi-objective genetic algorithm, and the multi-objective optimization of the Cantor fractal baffle micromixer is carried out. At different Reynolds numbers (Res), the three-dimensional Navier–Stokes equation is employed to numerically analyze the fluid flow and mixing in the microchannel. We choose the ratio of the three parameters associated with the geometry of the micromixer as design variables, and take the mixing index and pressure drop at the outlet of the micromixer as two objective functions for optimization. For the parameter study of the design space, the Latin hypercube sampling (LHS) method is used as an experimental design technique, and it is used to select design points in the design space. We use the proxy modeling of the response surface analysis (RSA) to approximate the objective function. The genetic algorithm is used to get the Pareto optimal frontier of the micromixer. K-means clustering is used to classify the optimal solution set, and we select representative design variables from it. Through multi-objective optimization, when Re = 1 and 10, the optimized mixing efficiency of the micromixer increased by 20.59% and 14.07% compared with the reference design, respectively. And we also prove that this multi-objective optimization method is applicable to any Res.
Mechanical behavior and constitutive model for loess samples under simulated acid rain conditions
Authors: Ye Xia , Chen Cong , Liu Enlong , Di Baofeng , Yu Yanyang 
Published: March 2022

AbstractAcid rain is mainly composed of sulfuric acid and nitric acid aqueous solutions, which can deteriorate the mechanical properties of soil and thus threaten the safety of soil engineerings. In this paper, the influence of sulfuric acid rain on mechanical properties of loess soil samples was studied. The diluted sulfuric acid solution has respectively pH 5.0, 4.0 and 3.0 to simulate the acid rain condition, and the triaxial compressional tests and scanning electron microscope were carried out to investigate the deteriorated properties and evolution of the microstructure of the saturated loess samples. The results demonstrated that acid rain made the porosity of loess samples larger, and changed the pore distribution and contacts of soil grains, so that the mechanical properties of loess samples varied in some degree. With the decrease of pH value, both the peak value of the deviatoric stress and volumetric contraction of loess samples decreased, which reduced the parameters of shear strength of loess samples. Furthermore, a framework of the chemical–mechanical model for loess under the action of acid rain was established, in which loess was considered as a porous medium material, and the influences of acid rain with different pH values were taken into account in the double-hardening constitutive model, and the model was also verified by the triaxial test results finally.
Post-ERCP Bile Leak
Authors: Mathew Shibi , Zacharias Prakash , Kumar Lijesh , Kumar Arun , Mathews John , James Thomas , Ahamed Hasim , Mohmed Bilal , Philip Mathew 
Published: March 2022

AbstractA 37-year-old female with no underlying comorbidities was referred for the evaluation of biliary stricture. Her magnetic resonance cholangiopancreatography showed a focal lesion in the left hepatic duct close to primary confluence causing a stricture and bilateral intrahepatic biliary radicle dilatation. Spyglass cholangioscopy was done and SpyBite biopsy was taken from the stricture. Repeated attempts at attaining deep cannulation of the right duct were unsuccessful. Patient developed right-sided abdominal pain the next day. Computed tomographic scan of the abdomen showed intra-abdominal fluid in the perihepatic region. Fluid was drained under ultrasound guidance. Though patient improved transiently, she had recurrence of pain after drain removal. A repeat endoscopic retrograde cholangiopancreatography (ERCP) was done and a leak was noted at the junction of right anterior and posterior hepatic ducts. Stenting was done to right anterior, right posterior, and left hepatic ducts. Over the next few days, she improved symptomatically. Though complications are inherent during ERCP, bile duct injury leading to bile leak is rare. Special caution has to be taken in high-risk cases to prevent bile duct injury. Though post-ERCP bile leak is a rare complication, early recognition with a high index of clinical suspicion and prompt management are the key factors in minimizing morbidity and mortality.
Cognitive Deficits in Patients with COVID-19 Infection during Their Hospital Stay: An Exploratory Study
Authors: Sahoo Swapnajeet , Suman Arzoo , Mehra Aseem , Nehra Ritu , Bhalla Ashish , Puri Goverdhan Dutt , Grover Sandeep 
Published: March 2022

Abstract

Background The literature on presence of cognitive deficits in patients recovered from coronavirus disease 2019 (COVID-19) infection is emerging. However, the data on whether cognitive deficits have its onset during the acute phase of illness has not been evaluated extensively.

Aim This article estimates the level of cognitive functioning of patients with COVID-19 while they were admitted to COVID-designated wards. Secondary objectives were to assess the influence of medical comorbidities, severity of COVID-19 infection, and depressive and anxiety symptoms on cognitive functioning in patients with COVID-19 infection.

Methods Sixty-six clinically stable patients with COVID-19 infection were evaluated during their inpatient stay on Hindi Montreal Cognitive Assessment scale (H-MoCA), Hindi Mini-Mental State Examination (HMSE) scale, Patient Health Questionnaire-9, and Generalized Anxiety Disorder Questionnaire -7.

Results The mean age of the study participants was 39.85 (standard deviation [SD] 16.89) years and the participants were evaluated after 9.34 (SD 4.98; median 9.0) days of being diagnosed with COVID-19 infection. About one-fourth (28.8%; n = 19) of the participants had cognitive impairment on HMSE and about two-fifths (n = 26; 39.39%) had cognitive impairment as per the cutoff used for H-MoCA. A higher level of cognitive deficits were seen among participants who were older, diagnosed with diabetes mellitus, and those who required oxygen support during their hospital stay prior to assessment.

Conclusion Low cognitive score was found in one-fourth (28.8%) to two-fifths (39.9%) of the persons, depending on the assessment scale among those with acute COVID-19 infection. Low cognitive score was more prevalent among the elderly, those with diabetes mellitus, and those who required oxygen support prior to the assessment.
Nonconvulsive Status Epilepticus: Current Status and Future Perspectives
Authors: Khanna Laxmi , Agarwal Nandini 
Published: March 2022

AbstractIntroduction Nonconvulsive status epilepticus is defined as a state of impaired consciousness with subtle motor manifestations and ongoing seizure activity in the electroencephalogram (EEG) for at least 30 minutes.Objectives and Methods This study of nonconvulsive status epilepticus and its outcomes was a retrospective analysis of the continuous bedside EEG recordings of 100 patients over 2 years (Aug 2017–July 2019) at the Neurophysiology Department in Sir Ganga Ram Hospital, New Delhi. There were two groups of patients in the study comprising of adults (72) and children (28). A comparison between the two groups was made based on the clinical presentation, etiology, EEG, MRI findings, treatment, and the consequences.Results and Conclusions In adults, nonconvulsive status had a high mortality rate, while in children, the associated comorbidities dominated and contributed to residual neurological sequelae. Early diagnosis and treatment at any age is essential to prevent cognitive decline and psychomotor retardation. Presently, bedside and ambulatory EEG recordings are used to capture the dynamic and rhythmic features of the ictal EEG. Continuous EEG monitoring enables bedside assessment of the effectiveness of treatment.
The early history of clicks in Nguni
Authors: Gunnink Hilde 
Published: March 2022

AbstractLanguage contact between migrating Bantu speakers and resident Khoisan speakers has resulted in the adoption of clicks in various southern African Bantu languages. This paper uses the comparative method to show that for one particular cluster of Bantu click languages, the Nguni languages, a large number of phonemic clicks can be reconstructed to its putative ancestor Proto-Nguni, including a palatal click rarely found in Bantu languages and no longer used as such in any living Nguni language. Although clicks have undergone subsequent developments in individual Nguni languages, no new click phonemes were acquired through language contact, showing that clicks were already present very early in the history of the Nguni languages. This relative chronology provides new insights into how the relations between Bantu- and Khoisan-speaking communities in southern Africa developed over time.
The hapax / type ratio
Authors: Van Wettere Niek 
Published: March 2022

AbstractThis article addresses one of the lesser-known productivity measures, namely the hapax / type ratio (HTR). Through a case study involving the Dutch semi-copularaken(“attain”), it is shown that the HTR more or less stabilizes from a certain sample size onwards. Moreover, this point of stabilization seems to coincide with an increased permanency of the hapaxes, i.e. the share of hapaxes that convert quickly to non-hapaxes is not as large as was the case at the beginning of the sampling process. Therefore, the stabilization of the HTR might be a good indicator of minimally required sample size in productivity studies, suggesting that the hapaxes are ‘non-incidental’ from this sample size onwards. However, I did not find a clear link between the onset of the stabilization of the HTR and the extent to which the inventory of types accounted for at the top of the frequency distribution is (quasi-)complete.
Aspects ofvæ(‘and’) as a discourse marker in Persian
Authors: Kazemian Reza , Amouzadeh Mohammad 
Published: March 2022

AbstractThis study investigates the functions ofvæ(‘and’) as a discourse marker in Persian. More specifically, this study accounts for certain aspects ofvæco-occurrences and their linearization order. Fraser’s model (forthcoming) was mainly employed to classify the multiple functions conveyed byvæ. A corpus-based approach was taken to provide an overview ofvæco-occurrences with other discourse markers. The data were collected from both written and spoken corpora. Quantitative and qualitative analyses were conducted to examine the frequency and the functional differences in the use ofvæin the data – namely, elaboration, inferential, contrast, and alternation. The results of the study indicate the mobile nature ofvæin its co-occurrences with other DMs. The findings also show that some modifications toFraser’s (forthcoming)DM co-occurrence principles are required to handle certain cases of language-specific behavior ofvæin Persian. The configuration suggested forvæuses and its multi-functionality will also shed some lights on cross-linguistic studies of its counterparts in other languages.
Necessary and sufficient conditions to Bernstein theorem of a Hessian equation
Authors: Du Shi-Zhong 
Published: March 2022

The Hessian quotient equations

S

k
,
l

(

D
2

u
)
≡

S
k

(

D
2

u
)

S
l

(

D
2

u
)

=
1
,

∀
x
∈

R

n

\begin{equation} S_{k,l}(D^2u)\equiv \frac {S_k(D^2u)}{S_l(D^2u)}=1, \ \ \forall x\in {\mathbb {R}}^n \end{equation}

were studied for

k
−

k-

th symmetric elementary function

S
k

(

D
2

u
)

S_k(D^2u)

of eigenvalues

λ
(

D
2

u
)

\lambda (D^2u)

of the Hessian matrix

D
2

u

D^2u

, where

0
≤
l
>
k
≤
n

0\leq l>k\leq n

. For

l
=
0

l=0

, (0.1) is reduced to a

k
−

k-

Hessian equation

S
k

(

D
2

u
)
=
1
,

∀
x
∈

R

n

.

\begin{equation} S_k(D^2u)=1, \ \ \forall x\in {\mathbb {R}}^n. \end{equation}

Two quadratic growth conditions were found by Bao-Cheng-Guan-Ji [American J. Math. 125 (2013), pp. 301–316] ensuring the Bernstein properties of (0.1) and (0.2) respectively. In this paper, we will drop the point wise quadratic growth condition of Bao-Cheng-Guan-Ji and prove three necessary and sufficient conditions to Bernstein property of (0.1) and (0.2), using a reverse isoperimetric type inequality, volume growth or

L
p

L^p

-integrability respectively. Our new volume growth or

L
p

−

L^p-

integrable conditions improve largely various previously known point wise conditions provided Bao et al.; Chen and Xiang [J. Differential Equations 267 (2019), pp. 52027–5219]; Cheng and Yau [Comm. Pure Appl. Math. 39 (1986), pp. 8397–866]; Li, Ren, and Wang [J. Funct. Anal. 270 (2016), pp. 26917–2714]; Yuan [Invent. Math. 150 (2002), pp. 1177–125], etc.
Who killed Bruce Lee? The hyponatraemia hypothesis
Authors: Villalvazo Priscila , Fernandez-Prado Raul , Niño Maria Dolores Sánchez , Carriazo Sol , Fernández-Fernández Beatriz , Ortiz Alberto , Perez-Gomez Maria Vanessa 
Published: March 2022

ABSTRACT
Bruce Lee brought attention to martial arts in the Western world and popularized the quote ‘Be water, my friend’. Lee died at the age of 32 years in Hong Kong on 20 July 1973, under mysterious circumstances. The cause of death is unknown, although numerous hypotheses have been proposed, from assassination by gangsters to the more recent suggestion in 2018 that he died from heatstroke. The necropsy showed cerebral oedema. A prior episode was diagnosed as cerebral oedema 2 months earlier. We now propose, based on an analysis of publicly available information, that the cause of death was cerebral oedema due to hyponatraemia. In other words, we propose that the kidney’s inability to excrete excess water killed Bruce Lee. In this regard, Lee had multiple risk factors for hyponatraemia that may have included high chronic fluid intake, factors that acutely increase thirst (marijuana) and factors that decrease the ability of the kidneys to excrete water by either promoting secretion of antidiuretic hormone (ADH) or interfering with water excretion mechanisms in kidney tubules: prescription drugs (diuretics, non-steroidal anti-inflammatory drugs, opioids, antiepileptic drugs), alcohol, chronic low solute intake, a past history of acute kidney injury and exercise.
Innovate to eliminate: a prerequisite in NTD programmes
Authors: Rust Jennifer , Clark Amy , Woodgate Mary , Koch Christina , Mohammed Taylor , Steinmann Peter , Krentel Alison , Torres-Vitolas Carlos A , Carlin Alexandra , Pavluck Alexandre 
Published: March 2022

Abstract
Innovation plays a critical role in progress towards achievement of the World Health Organization's road map for neglected tropical diseases 2021–2030. As disease prevalence decreases, the cost to identify and treat remaining cases goes up. Additionally, as programmes move to the surveillance phase, diagnostic tests need to be highly sensitive and affordable. Until the early end to the Ascend West and Central Africa programme, the Ascend Learning and Innovation Fund supported five projects from 2019 to 2021. Designed for innovation, the fund encompassed a range of activities, including operational research, product development and social behavioural change. This flexibility allowed innovation to bridge the gap between strategic policy and practical implementation, piloting and proving business models to respond to information found through Ascend.
Lubabegron fumarate acts as a β-adrenergic receptor antagonist in cultured bovine intramuscular and subcutaneous adipocytes
Authors: Hwang Jinhee H , Kube John C , Smith Stephen B 
Published: March 2022

Abstract
We hypothesized that lubabegron fumarate (LUB) (Experior, Elanco Animal Health, Greenfield, IN) would act as an antagonist to β-adrenergic receptor (β-AR) subtypes in primary bovine subcutaneous (s.c.) and intramuscular (i.m.) adipocytes differentiated in culture. This study employed LUB, dobutamine (DOB, a selective β1-agonist), salbutamol (SAL, a selective β2-agonist), and propranolol (PRO, a non-selective β-AR antagonist). Preadipocytes were isolated by standard techniques from bovine longissimus muscle and overlying s.c. adipose tissue and differentiated to adipocytes for 14 d. The adipocyte source x stage of differentiation interaction was significant for β-adrenergic receptors-1 (ADRB1) (P = 0.001) and ADRB2 (P = 0.01) in that expression of ADRB1 and ADRB2 was greater in s.c. adipocytes than in s.c. preadipocytes; expression of the ADRB1-3 did not change after differentiation of i.m. adipocytes. CCATT/enhancer-binding protein alpha (CEBPA) expression increased upon differentiation in both s.c. and i.m. adipocytes (P = 0.006). The source x stage of differentiation interaction was significant for peroxisome proliferator-activated receptor gamma (PPARG) (P ≤ 0.001) and fatty acid binding protein-4 (FABP4) (P = 0.004). Expression of PPARG increased after differentiation of s.c. preadipocytes to adipocytes, but PPARG expression did not change with differentiation of i.m. preadipocytes to adipocytes. FABP4 expression increased after differentiation of both s.c. and i.m. adipocytes, but FABP4 expression increased to a greater extent in s.c. adipocytes. In s.c. adipocytes, DOB elevated cAMP and glycerol production and protein kinase A (PKA) activity, and SAL increased PKA activity; these effects were abolished by LUB and PRO (P &lt; 0.001). Incubation of i.m. adipocytes with SAL increased cAMP production and PKA activity, which was attenuated by LUB and PRO (P ≤ 0.006). In s.c. adipocytes, SAL, LUB + SAL, and LUB + DOB upregulated hormone sensitive lipase (HSL) (P &lt; 0.001) and perilipin (P = 0.002) gene expression. In i.m. adipocytes, DOB and LUB + DOB increased HSL gene expression (P = 0.001) and LUB + SAL depressed adipose triglyceride lipase expression below control levels (P = 0.001). These results demonstrate that LUB is a β-AR antagonist at the β1-AR and β2-AR subtypes in s.c. adipocytes, and that s.c. and i.m. exhibit different responses to β-AA and LUB.
Technical Note: A method for determination of titanium dioxide concentration in fecal samples
Authors: Fowler Ashley L , Hayes Susan H , Crum Andrea D , Lawrence Laurie M 
Published: March 2022

Abstract
Titanium dioxide has been used as a marker for determining diet digestibility indirectly, but some authors have expressed difficulty in measuring TiO2 concentrations in fecal material. We developed an accurate and precise method to determine TiO2 concentrations in equine feces. The method includes dry-ashing samples, digestion with (NH4)2SO4 in concentrated sulfuric acid, followed by the addition of H2O2 to produce a yellow to orange color that can be read spectrophotometrically. Accuracy was tested by spike recovery, and precision was tested by examining the coefficient of variation (CV) between duplicates of 449 individual samples. The method described here was compared with a previously published method by examining CV between duplicates of samples analyzed using both methods and comparing them using a paired t-test. Titanium dioxide spike recovery averaged 106%, and the CV between duplicates averaged 4.0%, with 79% of sample pairs having a CV of &lt;5%. When compared with a previously published method, the method described here had a lower CV between duplicates (P &lt; 0.0001). The method described here provides an accurate and precise quantitative analytical procedure for TiO2 in equine fecal samples.
Effect of tofacitinib in a patient with inflammatory bowel disease–related arthritis
Authors: Lomborg Niels , Jensen Michael Dam 
Published: March 2022

ABSTRACT
Extraintestinal manifestations are common in patients with chronic inflammatory bowel disease (IBD). Peripheral arthritis occurs in ∼10% of patients with IBD. Treatment of both arthritis and the IBD disease is challenging, and involvement of both the rheumatologist and the gastroenterologist is essential. We present a case with concomitant polyarthritis and ulcerative colitis successfully treated with tofacitinib. A 32-year-old woman with ulcerative colitis currently treated with azathioprine and adalimumab was referred to our rheumatology clinic due to pain and swelling in her knees and finger joints. The patient was diagnosed with IBD-related arthritis. Intra-articular injection with steroid was initially effective, but the arthritis was persistent. Treatment attempts with salazopyrine and golimumab were discontinued due to drug-induced pancreatitis and urticaria, respectively. Subsequently treatment with tofacitinib 10 mg twice daily was effective within weeks, and apart from a mild folliculitis, there were no side effects. With this case report, we would like to draw attention to the fact that treatment with tofacitinib may constitute a good treatment option in refractory cases of IBD-related arthritis.