bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhizo-inoculation of phosphate solubilizing bacteria strains to improve rice (Oryza sativa L. var. FARO 44) growth under ferruginous ultisol conditions.
Authors: Saheed Musa Ibrahim , Ikhajiagbe Beckley 
Published: February 2022

Abstract
The research investigated the possibility of phosphate solubilizing bacteria (PSB) with plant growth-promoting (PGP) capabilities to improve growth properties of rice plant under ferruginous ultisol (FU) condition through rhizo-inoculation strategy. The PSB with PGP properties used in this research were Bacillus cereus strain GGBSU-1, Proteus mirabilis strain TL14-1 and Klebsiella variicola strain AUH-KAM-9 that were previously isolated and characterized following the 16S rRNA gene sequencing. The rice seeds were sown in a composite FU soil sample and a humus soil (control) and then rhizo-inoculated along the root region of the growing rice seedling at 16 days after sowing. The rice plant was studied for differences in morphological, physiological and biomass parameters for 16 weeks after rhizo-inoculation. Results showed that the FU soil used in the study had high pH, low bioavailable phosphorus, low water holding capacity and high iron levels which has led to a low growth properties of rice seeds sown in FU soil without rhizo-inoculation. After rhizo-inoculation, a significant increase in plant height and physiological parameters were observed in the rice plant grown in the FU soil as against the control and the rice plant in FU soil without inoculation except for terpenoid which is usually known to signify biotic stress and as part of plant defense mechanism. Generally, rhizo-inoculation of rice seedling with the three PSBs under FU soil condition significantly improved growth properties of the rice plant. This suggest the ability of the PSBs to solubilize and mineralize soil phosphate and improve its availability for plant use in phosphate stressed soil, thereby improving plant growth properties.
Identification Comparative Analysis of mRNAs and lncRNAs in Regulating the Development of Goat Skeletal Muscle
Authors: Zhao Xiuhui , Ye Junning , Xue Huiwen , Zou Xian , Liu Guangbin , Deng Ming , Sun Baoli , Guo Yongqing , Liu Dewu , Li Yaokun 
Published: February 2022

Abstract
Background: Meat yield and quality is one of the most important economic traits of livestock. Long non-coding RNAs (lncRNAs) is involved in the biological process of muscle differentiation and development. However, few studies have explored the regulatory role of lncRNA on muscle development after birth.Results: The longissimus dorsi muscle of Leizhou black goat aged 0, 3 and 6 months was used to identify differential mRNA and differential lncRNA by high-throughput RNA sequencing. GO, KEGG and interaction network were used to analyzed the differential genes. We found that some target genes of DE-mRNA and DE-lncRNA were mainly involved CN-NFAT signal pathway and the formation of branch fibers, which is related to normal muscle development. ENSCHIG00000006085 and ENSCHIG00000023270 are significantly concentrated in the biological process related to urea transporters, which has an important effect on maintaining the normal development of goats. ENSCHIG00000006085 and ENSCHIG00000023270 may be involved in the degradation of intracellular proteins and METTL11B may play a role in methylation modification of muscle proteins.Conclusions: Our results show that some lncRNAs are involved in the regulation of protein during goat muscle development as well as provide a valuable resource for lncRNA studies and make a deeper understanding of the genetic basis and molecular mechanisms of the development of goat skeletal muscle.
Diarrhea Prevalence and Associated Factors among Under-Five Children in the Periphery Area of Azezo Sub-city, Gondar, Northwest Ethiopia: A community based cross-sectional study
Authors: Bitew Bikes Destaw , Getachew Atalay , Azanaw Jember 
Published: February 2022

Abstract
Background: Although there has been a global decrease in childhood diarrheal disease in parallel with improvements in the standard of living, it remains a significant public health problem that occurs due to poor WASH status and other related factors that cause massive childhood morbidity and mortality particularly in sub-Saharan Africa countries including Ethiopia. Objective: To assess diarrheal disease prevalence and associated factors among under-five children in the periphery area of Azezo sub-city, Gondar, northwest Ethiopia. Methods: A community-based cross-sectional study was conducted in April 2019. A simple random sampling technique was applied to recruit the eligible clusters/villages. Structured interview questionnaires were used to collect data. The completed data were entered into Epi Info version 7 and exported to SPSS version 20 for further analysis. A binary logistic regression model was used to process bivariate and multivariable analysis of the data to establish the association between dependent and independent variables. The adjusted odds ratio (AOR) with 95% CI was used for the interpretation of data after controlling the confounders. Results: The two-week prevalence of U5C diarrheal disease was 24.9 % with 95% CI: (20.4 – 29.7). Age group of 1-12months [AOR: 9.22, 95%CI: (2.93-29.04)], age group of 13-24months [AOR: 4.44, 95%CI: (1.87-10.56)], low monthly income (AOR: 3.68, 95% CI: (1.81-7.51)], small family size [AOR: 0.32, 95% CI: (0.16-0.65)], poor hand washing practice [AOR: 8.37, 95 % CI: (3.12-22.52), and immediate feed for cooked foods [AOR: 0.39, 95%CI: (0.19-0.81)] were significantly associated factors with childhood diarrhea. Conclusion: Diarrhea was a common health problem among under-five children in the periphery area of Azezo sub-city. Age of children, family size, monthly income, hand-washing practice, and feeding time for cooked food were identified statistically significant risk factors. Therefore, an appropriate intervention program through health education would be recommended with a focus on identified risk factors to reduce the burden of diarrheal diseases.
Sustainable Development, Renewable Energy Transformation and Employment Impact in the EU
Authors: Swain Ranjula Bali , Karimu Amin , Gråd Erik 
Published: February 2022

Abstract
A successful transition towards renewable energy systems in the European Union is expected to improve growth, reduce greenhouse gas emissions and create employment. Analysing recent data from 28 European Union (EU) countries, we investigate the potential interlinkages in employment, renewable energy and non-renewable energy amongst the EU countries. We further examine assess the contributions of renewable energy and non-renewable energy to the future variation in employment, output and carbon emissions within the EU. Our results suggest that renewable energy has a positive and significant net employment impact for EU. We further find that renewable energy consumption contributes substantially to the future variability in employment both for the short and the medium term. Also, carbon-dioxide emissions negatively impact the employment level in the EU.
Near-infrared Spectroscopy in Cerebral Oxygenation Monitoring in Full-term Neonates During Transition: Prospective Cohort Study
Authors: Farag Marwa , Ghazal Hesham , Ibrahim Alaa , Khalifa Mohammed , Hammad Bahaa 
Published: February 2022

Abstract
BackgroundBrain is the most important organ in resuscitation. NIRS-measured cerebral oxygenation is evolving brain monitoring tool for neonatal resuscitation.MethodWe undertook a prospective observational study for monitoring of cerebral oxygenation and peripheral preductal saturation at 1 , 5 and 10 minutes after birth to establish centile chart normative for monitoring of full term neonates during transition. Fractional tissue oxygen extraction was calculated as well. In addition to studying factors affecting cerebral oxygenation at those points in time.Results 60 healthy term neonates were enrolled to define reference ranges and centile charts of cerebral oxygenation at 1, 5, and 10 minutes after birth. The strongest correlations between cerebral oxygenation metrics and peripheral preductal saturation were at 5 minutes after birth. The most significant factor affecting NIRS-measured crSO2 in healthy full term neonates was mode of delivery. This work was registered in the cinicaltrial.gov NCT05158881.Conclusions Normal references of cerebral oxygenation metrics can be used to guide intervention during neonatal resuscitation. Caesarean section is the most significant factor affecting cerebral oxygenation during the transition of healthy full term neonates.
Prognostic Significance of Circadian Gene Expression in Lung Cancer
Authors: Liang Long , Wang Bingbing , Duan Hongxia , Zeng Jie , Xie Shuanshuan , Wang Changhui 
Published: February 2022

Abstract
Objective To explore the expression and prognostic significance of circadian genes (PER1, PER2, PER3, CRY1, CRY2, CLOCK and BMAL1) in lung cancer. Methods mRNA expressions of circadian rhythm genes in lung cancer and normal tissues were analyzed using the OMINE database. The functions of circadian genes in lung cancer were analyzed using the cBioPortal platform and OncoPrint. The association between the expression level of circadian genes and overall survival (OS) of lung cancer patients was analyzed using the Kaplan-Meier Plotter database. Results Analysis of the ONCOMINE database showed that the mR N A expression levels of PER1-3, CRY-2, CLOCK and BMAL1 were lower in lung cancer tissues than those in normal tissues. The cBioPortal platform and OncoPrint database showed that each circadian gene underwent a change ranging from 2.5% to 19.1% with the type of change including gene mutation, amplification, deletion, fusion and multiple alterations, of which gene mutation was the most prevalent. Kaplan-Meier analysis revealed that a decreased circadian gene expression level was significantly correlated with a shorter OS (P<0.05). In addition, the expression level of circadian genes also varied with the lung cancer subtype.Conclusions Circadian genes showed low expression levels in lung cancer, which was significantly correlated with a shorter survival. In addition, the aberrant expression of circadian genes in lung cancer is mainly caused by gene mutation.
Ultrasound Dynamic Monitoring of The Inner Diameter of The Inferior Vena Cava To Guide The Application of Continuous Renal Replacement Therapy In Patients With Renal Failure Combined With Acute Heart Failure
Authors: Yu Guang , Tao Shaoyu , Jin Yingzhi , Li Wanxia , Hu Zanqun , Fang Xiaowei 
Published: February 2022

Abstract
Objective To explore the application value of bedside ultrasound dynamic monitoring of inferior vena cava diameter (IVCD) and collapse with sniff (IVCCI) to guide the application value of dehydration adjustment in continuous renal replacement therapy (CRRT) in patients with renal failure combined with acute heart failure. Methods We selected 90 patients with renal failure and acute heart failure who required continuous renal replacement therapy in the intensive care unit from January 2019 to June 2021. According to different blood volume assessment methods, patients were randomly divided into the ultrasound group, the experience group, and the control group. The inspection indicators of creatinine, K+, and NT-proBNP, the clinical indicators of improvement time of heart failure, time of continuous renal replacement therapy, use time of ventilator, ICU hospitalization time, and use time of vasopressor use and the incidence of adverse event were compared among the three groups. Results There were no significant differences in creatinine, K+, and NT-proBNP between the three groups before and after treatment (P>0.05). The improvement time of heart failure, time of continuous renal replacement therapy, and ICU hospitalization time in the ultrasound and experience group were lower than the control group, and the difference between the groups was statistically significant (P<0.05). The use time of ventilator in the ultrasound and experience group was lower than the control group, there was a statistically significant difference between the ultrasound group and the control group (P<0.05). The use time of vasopressor in the ultrasound group and the control group was lower than the experience group, and the difference between the groups was a statistically significant time(P<0.05). The incidence of adverse events in the ultrasound group was lower than the experience group and the control group, and the difference between the groups was a statistically significant time(P<0.05). Conclusion Ultrasound dynamic monitoring of inferior vena cava diameter and collapse with sniff can more accurately assess the blood volume status, and provide a better guidance effect for the accurate dehydration of continuous renal replacement therapy and the rapid relief of heart failure symptoms in patients with renal failure and acute heart failure.
Classification of Parkinson’s Disease and Its Stages Using Machine Learning
Authors: Templeton John Michael , Poellabauer Christian , Schneider Sandra 
Published: February 2022

Abstract
As digital health technology becomes more pervasive, machine learning (ML) provides a robust way to analyze and interpret the myriad of collected features. The purpose of this work is to use ML classification to assess the benefits and relevance of features from clinically relevant sources (e.g., tablet-based assessments, self-reported metrics, and functional movement assessments), as they relate to Parkinson's Disease (PD) and its stages (Hoehn and Yahr (H&Y) Stages 1 - 5). Further, this work aims to compare perceived versus actual neurocognitive abilities. In this study, 75 participants (n = 50 PD; n = 25 control) completed 14 tablet-based neurocognitive functional tests (e.g., motor, memory, speech, executive, and multi-function), functional movement assessments (e.g., Berg Balance Scale), and standardized health questionnaires. Significant features were identified using decision tree classification. Device magnitude of acceleration was significant in 12 of 14 tests (85.7%), regardless of test type. For classification between diagnosed and control populations, 17 motor, 9 accuracy, and 8 timing features were significant. For classification between early (H&Y Stages 1 and 2) and advanced (H&Y Stages 3, 4, and 5) stages of PD, 7 motor, 12 accuracy, and 14 timing features were significant. Perceived functionality of individuals in early-stage PD was 21.6% lower than actual scores with notable perceived deficits in memory and executive function. However, individuals in advanced stages had elevated perceptions (1.57x) for executive and behavioral functions compared to early-stage populations. Machine learning in digital health systems allows for a more comprehensive understanding of neurodegenerative diseases and their stages. ML may also depict new features that influence the ways digital health technology should be configured. Updates to these systems will ultimately aid clinicians, diagnosed populations, and caretakers in monitoring and assessing neurodegenerative diseases.
Calculated cardiovascular risk after conversion from calcineurin inhibitor to belatacept in kidney transplant recipients: A randomized controlled trial
Authors: Bredewold Obbo W. , Chan Joe , Svensson My , Bruchfeld Annette , Fijter Johan W. , Furuland Hans , Grinyo Josep M. , Hartmann Anders , Holdaas Hallvard , Hellberg Olof , Jardine Alan , Mjörnstedt Lars , Skov Karin , Smerud Knut T. , Soveri Inga , Sörensen Sören S. , Zonneveld Anton-Jan , Fellstrom Bengt 
Published: February 2022

Abstract
In renal transplant recipients (RTRs), a belatacept-based immunosuppressive regimen is associated with beneficial effects on cardiovascular (CV) risk factors compared with calcineurin inhibitor (CNI)-based regimens. The aim of this randomized, multi-national trial was to compare calculated CV risk between belatacept and CNI (predominantly tacrolimus) treatments using a valdidated model developed for RTRs. From 9 transplant centers, RTRs from 3 to 60 months post-transplantation were recruited to either continue treatment with a CNI-based regimen or switch to belatacept. We compared the change in estimated 7-year risk of major adverse cardiovascular events (MACE) and all-cause mortality after 12 months of treatment. In the 105 RTRs randomized, we found no differences between the treatment groups in predicted risk for MACE or mortality. Diastolic blood pressure was lower after belatacept treatment compared with CNI. The mean changes in traditional CV risk factors, including renal transplant function, were otherwise similar in both treatment groups. The belatacept group had four acute rejection episodes; two were severe rejections, of which one led to graft loss. In conclusion, we found no effects on calculated CV risk by switching to belatacept treatment.
Flow and aerosol dispersion from wind musical instruments
Authors: Brosseau Quentin , Ran Ranjiangshang , Graham Ian , Jerolmack Douglas , Arratia Paulo 
Published: February 2022

Abstract
In the midst of the SARS-COVID-19 pandemic, many live musical activities had to be postponed and even cancelled to protect musicians and audience. Orchestral ensembles face a particular challenge of contamination because they are personnel heavy and instrumentally diverse. A chief concern is whether wind instruments are vectors of contamination through aerosol dispersion. This study, made possible by the participation of members of the Philadelphia Orchestra, brings insight on the modes of production and early life of aerosols of human origin emitted by wind instruments. We find that these instruments produce aerosol levels that are comparable to normal speech in quantity and size distribution. However, the exit jet flow speeds are lower than violent expiratory events (coughing, sneezing). For most wind instruments, the flow decays to background indoor-air levels approximately 2 m away from the instrument's opening. Long range aerosol dispersion is thus via ambient air currents.
Prevalence and complications of diabetes mellitus In India - A systematic review
Authors: Govindaswamy Swathy , P.S Dhivya 
Published: February 2022

Abstract
Background

Diabetes is progressively becoming a vital chronic disease burden worldwide, mainly in developing countries such as India; this necessitates a shift in healthcare priorities and advanced data on the epidemiology and impact of diabetes to help plan and prioritize health programs. We systematically reviewed the literature on diabetes prevalence and its complications in India.
Methods

This systematic review focuses on diabetes prevalence and complications in India from January 2000 to September 2021. Literature searches were conducted using electronic databases.
Results

Diabetes prevalence ranged from 2.02% in rural Madhya Pradesh to 40.3% in Tamil Nadu. Diabetes prevalence was significantly higher in urban areas than in rural areas. The prevalence of pre-diabetes varied across Indian states ranging from 2.4% in Meghalaya to 47.6% in Delhi. The prevalence of chronic diabetes complications ranged from 4.8–21.7% for retinopathy, 0.9–62.3%% for nephropathy, and 10.5–44.9% for neuropathy.
Conclusions

Diabetes is a significant and widespread health problem in India. Dissimilarity in the prevalence of diabetes between individual states is observed. Most diabetes patients experience chronic complications of diabetes. Consequently, it is essential to map the urgent preventive approach to reduce the further increase in areas with high prevalence.
Health Economics And Quality of Life Between Uncut Roux-En-Y And Roux-En-Y Reconstruction After Total Gastrectomy
Authors: Zhu Guang-xu , Zhou Sheng-jie , Shen Xiao-ru , Yu Lei , Qu Jian-jun 
Published: February 2022

Abstract
Purpose: This study aims to compare the health economics and quality of life between uncut Roux-en-Y and Roux-en-Y reconstruction after laparoscopic-assisted total gastrectomy.Methods: Between January 2016 and January 2019, 164 patients underwent laparoscopic-assisted total gastrectomy (uncut Roux-en-Y reconstruction, n = 71; Roux-en-Y, n = 93). The patients’ data were collected and reviewed retrospectively.Results: The perioperative index, operating time, digestive tract reconstruction time, and first postoperative exhaust time of the U-RY group were shorter than those of the RY group (P < 0.05). Differences in the quality of life (QoL) index 12 months postoperation were not significantly different between the groups (P > 0.05). No recanalization was found in the U-RY obliterated afferent jejunal limb. The cost of mechanical staples andaverage hospitalization in the U-RY group were significantly lower than that in the RY group (P < 0.05).Conclusion: The postoperative health economics of U-RY reconstruction may be superior to those of RY reconstruction after laparoscopic-assisted total gastrectomy. The QoL of the U-RY group is similar to that of the RY group.
Short Version of The Depression Anxiety Stress Scal-21: Is It Valid For Jordanian Adults
Authors: Murad Odeh 
Published: February 2022

Abstract
Background: Given the potential utility of depression anxiety stress scale-21 and the availability of a reliable Arabic version, the current study aimed to collect information about the factorial structure and psychometric properties of the Jordanian version by administering it to adult members of the community. Thus, the depression-anxiety-stress scale was used in examining mental disorders in Jordanian adults. Methods: The study included adults of both sexes aged 18 to 72 years. The reliability of the overall DASS-21 scores and the three DASS-21 subscales were calculated. Exploratory factor analysis was used to test construct validity. Confirmatory factor analysis was performed for the two models (one-factor and three-factor models) for DASS-21 to determine the best factor structure for DASS-21 in the adult sample.Results: The findings revealed that the DASS-21 has high reliability and validity indicators, with Cronbach's alpha values exceeding 0.80. Pearson's correlation between DASS-21 and the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI) were strongly positive, indicating that DASS-21 has sufficient convergent and divergent validity. The exploratory factor analysis showed that the three-factor model had the best indicators, and the confirmatory factor analysis results confirmed that the three-factor model was the fittest and most appropriate. Conclusion: The current study's findings suggest that the Jordanian version of the DASS-21 can be used as a reliable and valid scale for measuring depression, anxiety, and stress in adults.