bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Scotland’s fighting fields’: the mobilisation of workers in rural Scotland during the Second World War
Authors: Moffat Michelle 
Published: February 2022

AbstractAs the Battle of the Atlantic threatened Britain’s importation of food and forestry supplies, authorities intensified plans to rapidly increase domestic production. In Scotland, this was a herculean task in rural communities decimated by land clearances, economic depression, and population decline. Against the odds, the mobilisation of a range of workers enabled Scottish agriculture and forestry to make impressive gains in production, and significantly impacted Scotland’s ability to meet wartime production targets. This article examines the contributions of four diverse groups of labourers that toiled in Scottish fields and forests: compelled labourers, including conscientious objectors and prisoners of war; adult and child volunteers; women; and foreign lumberjacks from Canada, Newfoundland, and British Honduras. This original research supplements our knowledge of the British rural workforce during the Second World War, and raises the issue of wartime migration and its effects on rural communities.
NOVA food groups’ consumption associated with nutrient intake profile of school children aged 8–12 years
Authors: de Lacerda Arabele Teixeira , do Carmo Ariene Silva , Maia de Sousa Taciana , dos Santos Luana Caroline 
Published: February 2022

AbstractObjective:To evaluate the association between the consumption of NOVA food groups (classification based on the nature, extent and purpose of food processing) and the intake of energy, macro and micronutrients among school children.Design:Cross-sectional study. Food consumption was assessed by two 24-h dietary recalls on non-consecutive days. Energy from each NOVA food groups – ultra-processed foods, unprocessed or minimally processed foods, processed culinary ingredients and processed foods – was estimated. For analysis, the percentage of energy from ultra-processed foods and unprocessed or minimally processed foods were categorised into tertiles and associated with intake of energy, macro and micronutrients using analysis of covariance and linear regression.Setting:Public schools in Belo Horizonte, Minas Gerais, Brazil.Participants:School children aged 8–12 years (n 797; 406 girls; 391 boys).Results:Mean energy intake was 2050·18 ± 966·83 kcal/d, 25·8 % was from ultra-processed foods, 56·7 % from unprocessed or minimally processed foods, 8·9 % from processed culinary ingredients and 8·6 % from processed foods. A higher energy contribution from ultra-processed foods was negatively associated with the intake of protein, fibre, vitamin A, Fe and Zn (P < 0·001) and positively associated with total energy, lipid and Na intake (P < 0·001). Concurrently, a higher energy contribution from unprocessed or minimally processed foods was positively associated with the consumption of protein, fibre, Fe and Zn (P < 0·001) and negatively associated with total energy (P = 0·002), lipid and Na intake (P < 0·001).Conclusions:In conclusion, higher ultra-processed food consumption presented a negative association with the nutrient intake profile of school children.
Kant and Religion Roundtable
Authors: Wood Allen 
Published: February 2022

AbstractThis article provides a summary and some replies to points offered in the Kantian Review Roundtable discussion of my recent book Kant and Religion. The main themes are as follows: Kant’s project in the Religion; religious thinking as symbolic; the rational interpretation of revelation and of religious symbols; Kant’s moral argument for religious faith; the ‘psychological’-moral argument; Kant’s thesis that human nature contains a radical propensity to evil; evil and human sociability; evil and freedom; divine forgiveness and the sinner’s self-acceptance; Kant’s Religion as a subject of philosophical controversy.
TOWARDS THE INEVITABILITY OF NON-CLASSICAL PROBABILITY
Authors: MOLINARI GIACOMO 
Published: February 2022

AbstractThis paper generalises an argument for probabilism due to Lindley [9]. I extend the argument to a number of non-classical logical settings whose truth-values, seen here as ideal aims for belief, are in the set
$\{0,1\}$
, and where logical consequence
$\models $
is given the “no-drop” characterization. First I will show that, in each of these settings, an agent’s credence can only avoid accuracy-domination if its canonical transform is a (possibly non-classical) probability function. In other words, if an agent values accuracy as the fundamental epistemic virtue, it is a necessary requirement for rationality that her credence have some probabilistic structure. Then I show that for a certain class of reasonable measures of inaccuracy, having such a probabilistic structure is sufficient to avoid accuracy-domination in these non-classical settings.
Rupture Heterogeneity and Directivity Effects in Back‐Projection Analysis
Authors: Li Bo , Wu Baoning , Bao Han , Oglesby David D. , Ghosh Abhijit , Gabriel Alice‐Agnes , Meng Lingsen , Chu Risheng 
Published: February 2022

AbstractThe back projection method is a tremendously powerful technique for investigating the time dependent earthquake source, but its physical interpretation is elusive. We investigate how earthquake rupture heterogeneity and directivity can affect back‐projection results (imaged location and beam power) using synthetic earthquake models. Rather than attempting to model the dynamics of any specific real earthquake, we use idealized kinematic rupture models, with constant or varying rupture velocity, peak slip rate, and fault‐local strike orientation along unilateral or bilateral rupturing faults, and perform back‐projection with the resultant synthetic seismograms. Our experiments show back‐projection can track only heterogeneous rupture processes; homogeneous rupture is not resolved in our synthetic experiments. The amplitude of beam power does not necessarily correlate with the amplitude of any specific rupture parameter (e.g., slip rate or rupture velocity) at the back‐projected location. Rather, it depends on the spatial heterogeneity around the back‐projected rupture front, and is affected by the rupture directivity. A shorter characteristic wavelength of the source heterogeneity or rupture directivity toward the array results in strong beam power in higher frequency. We derive an equation based on Doppler theory to relate the wavelength of heterogeneity with synthetic seismogram frequency. This theoretical relation can explain the frequency‐ and array‐dependent back‐projection results not only in our synthetic experiments but also to analyze the 2019 M7.6 bilaterally rupturing New Ireland earthquake. Our study provides a novel perspective to physically interpret back‐projection results and to retrieve information about earthquake rupture characteristics.
Coupled Poroelastic Modeling of Hydraulic Fracturing‐Induced Seismicity: Implications for Understanding the Post Shut‐In ML 2.9 Earthquake at the Preston New Road, UK
Authors: Cao Wenzhuo , Verdon James P. , Tao Ming 
Published: February 2022

AbstractPost‐injection seismicity associated with hydraulic stimulation has posed great challenges to hydraulic fracturing operations. This work aims to identify the causal mechanism of the post shut‐in ML 2.9 earthquake in August 2019 at the Preston New Road, UK, amongst three plausible mechanisms, that is, the post shut‐in pore pressure diffusion, poroelastic stressing on a non‐overpressurized fault, and poroelastic stressing on an overpressurized fault. A 3D fully coupled poroelastic model that considers the poroelastic solid deformation, fluid flow in both porous rocks and fracture structures, and hydrofracturing‐induced pressure perturbations was developed to simulate the hydromechanical response of the shale reservoir formation to hydraulic fracturing operations at the site. Based on the model results, Coulomb stress changes and seismicity rate were further evaluated on the PNR‐2 fault responsible for the earthquake. Model results have shown that increased pore pressure plays a dominant role in triggering the fault slippage, although the poroelastic stress may have acted to promote the slippage. Amongst the three plausible mechanisms, the post shut‐in pore pressure diffusion is the most favored in terms of Coulomb stress change, seismicity rate, timing of fault slippage and rupture area. The coupled modeling results suggested that the occurrence of the post shut‐in ML 2.9 earthquake was a three‐staged process, involving first propagation of fracture tips that stimulated surrounding reservoir formations, then hydraulic connection with and subsequent pore pressure diffusion to the conductive PNR‐2 fault, and eventually fault activation primarily under the direct impact of increased pore pressure.
Evolution and Transformation of the North Icelandic Irminger Current Along the North Iceland Shelf
Authors: Semper Stefanie , Våge Kjetil , Pickart Robert S. , Jónsson Steingrímur , Valdimarsson Héðinn 
Published: February 2022

AbstractThe North Icelandic Irminger Current (NIIC) flowing northward through Denmark Strait is the main source of salt and heat to the north Iceland shelf. We quantify its along‐stream evolution using the first high‐resolution hydrographic/velocity survey north of Iceland that spans the entire shelf along with historical hydrographic measurements as well as data from satellites and surface drifters. The NIIC generally follows the shelf break. Portions of the flow recirculate near Denmark Strait and the Kolbeinsey Ridge. The current's volume transport diminishes northeast of Iceland before it merges with the Atlantic Water inflow east of Iceland. The hydrographic properties of the current are modified along its entire pathway, predominantly because of lateral mixing with cold, fresh offshore waters rather than air‐sea interaction. Progressing eastward, the NIIC cools and freshens by approximately 0.3°C and 0.02–0.03 g kg−1 per 100 km, respectively, in both summer and winter. Dense‐water formation on the shelf is limited, occurring only sporadically in the historical record. The hydrographic properties of this locally formed water match the lighter portion of the North Icelandic Jet (NIJ), which emerges northeast of Iceland and transports dense water toward Denmark Strait. In the region northeast of Iceland, the NIIC is prone to baroclinic instability. Enhanced eddy kinetic energy over the steep slope there suggests a dynamical link between eddies shed by the NIIC and the formation of the NIJ as previously hypothesized. Thus, while the NIIC rarely supplies the NIJ directly, it may be dynamically important for the overturning circulation in the Nordic Seas.
Regional Transport of PM2.5 and O3 Based on Complex Network Method and Chemical Transport Model in the Yangtze River Delta, China
Authors: Wang Qian , Wang Xiaohao , Huang Ruizhu , Wu Jianbin , Xiao Yu , Hu Ming , Fu Qingyan , Duan Yusen , Chen Jianmin 
Published: February 2022

AbstractGround‐level ozone (O3) and atmospheric fine particulate matter (PM2.5) pollution are the major challenges for continually improving air quality in the Yangtze River Delta (YRD) region of China. Understanding regional transport patterns of PM2.5 and O3 pollution is essential for the development of regional cooperative prevention strategies. This study shows the annual concentration of PM2.5 in the YRD decreased by 18.5% from 2015 to 2018, while the mean values of the daily maximum 8‐hr average (MDA8) O3 concentration from March to October increased by 16.3%. A complex network method is utilized to investigate the regional transport of PM2.5 and O3 in different grid cells (nodes). The source apportionment method within the chemistry transport model is applied to verify the reliability of the complex network method. Interregional and intraregional transport play an important role in both PM2.5 and O3 over the YRD. The northern part of the YRD contributes much more than other areas, while the central part of the YRD, especially the southern part of Jiangsu, is the largest contributor of O3 in the YRD in the summer, accounting for about 70%. Intraregional transport plays more of a major role in increasing PM2.5 pollution than O3 pollution. This study not only verifies the transport patterns of heavy pollution through the complex network method and traditional source apportionment technology, it also reveals that both methods provide great potential in understanding transport patterns and air pollution relationships, which are the solid foundation for emission mitigation in the YRD region.
Satellite Observed Sensitivity of Tropical Clouds and Moisture to Sea Surface Temperature on Various Time and Space Scales: 1. Focus on High Level Cloud Situations Over Ocean
Authors: Höjgård‐Olsen Erik , Chepfer Hélène , Brogniez Hélène 
Published: February 2022

AbstractThis study examines variations in high cloud properties and relative humidity (RH) with sea surface temperature (SST) over tropical oceans (30°N–30°S) using spaceborne lidar and microwave radiometer observations. The mean values over the tropics indicate that middle‐tropospheric RH increases, high cloud covers decrease and cloud altitudes rise with SST. These signatures are consistent with the hypotheses proposed in the literature. The analysis of this same data set but at the scale of local processes shows different behaviors for SSTs <302 K and SSTs >302 K. Between 299 and 302 K, middle‐tropospheric RH, opaque cloud cover, and cloud top altitude increase together with SST, while optically thin cloud cover decreases. Over SSTs >302 K, middle‐tropospheric RH, opaque cloud cover, and opaque cloud top altitude decrease with SST, while the cover of optically thin clouds increases. Interestingly, the altitude of high clouds (not the cloud top) increases monotonically with SST from 299 to 305 K on a range of space and time scales, and the altitude of optically thin clouds remains higher than that of opaque clouds. The observed relationships on different time and space scales are compared to simulations of a global atmospheric model. Despite systematic biases, the model reproduces the sensitivity of the middle‐tropospheric RH and cloud altitude to SST rather well but fails to reproduce the variations of the balance between high opaque cloud cover and high optically thin cloud cover.
Uncertainties in Evaluating Global Electric Circuit Interactions With Atmospheric Clouds and Aerosols, and Consequences for Radiation and Dynamics
Authors: Tinsley Brian A. 
Published: February 2022

AbstractObservations and theory relevant to evaluating the importance of the effect of Ionosphere‐Earth current density, JZ, in the global electric circuit on cloud microphysics and cloud opacity at high latitudes, with presumed consequences for surface pressure, are reviewed and updated. The day‐to‐day input variations are less than 10% of their mean values, as are the reported cloud and pressure effects, but could be indicative of more important longer‐term effects, and of neglected processes in aerosol‐cloud interactions. There is consistent evidence for responses to both externally (solar‐wind) and internally (thunderstorm and shower‐cloud) generated changes in JZ and cloud opacity. The pressure correlations show non‐stationary behavior, with changes in phase relative to that of the solar wind input and JZ variations on interdecadal timescales. These might be due to the non‐stationary nature of the solar wind, and non‐stationary aerosol populations. For modeling the cloud effects there are considerable uncertainties in the size and charge distributions of aerosol particles, droplets, and ice particles. The cloud radiative coupling with periodic solar wind inputs may nudge internal tropospheric waves into phase coherence at times when the amplitude of the solar input and the duration of the input trains exceed minimum values.
Genetically encoded BRET-activated photodynamic therapy for the treatment of deep-seated tumors
Authors: Shramova Elena I. , Chumakov Stepan P. , Shipunova Victoria O. , Ryabova Anastasiya V. , Telegin Georgij B. , Kabashin Andrei V. , Deyev Sergey M. , Proshkina Galina M. 
Published: February 2022

AbstractPhotodynamic therapy (PDT) is one of the most appealing photonic modalities for cancer treatment based on anticancer activity of light-induced photosensitizer-mediated reactive oxygen species (ROS), but a limited depth of light penetration into tissues does not make possible the treatment of deep-seated neoplasms and thus complicates its widespread clinical adoption. Here, we introduce the concept of genetically encoded bioluminescence resonance energy transfer (BRET)-activated PDT, which combines an internal light source and a photosensitizer (PS) in a single-genetic construct, which can be delivered to tumors seated at virtually unlimited depth and then triggered by the injection of a substrate to initiate their treatment. To illustrate the concept, we engineered genetic NanoLuc-miniSOG BRET pair, combining NanoLuc luciferase flashlight and phototoxic flavoprotein miniSOG, which generates ROS under luciferase-substrate injection. We prove the concept feasibility in mice bearing NanoLuc-miniSOG expressing tumor, followed by its elimination under the luciferase-substrate administration. Then, we demonstrate a targeted delivery of NanoLuc-miniSOG gene, via tumor-specific lentiviral particles, into a tumor, followed by its successful elimination, with tumor-growth inhibition (TGI) coefficient exceeding 67%, which confirms a great therapeutic potential of the proposed concept. In conclusion, this study provides proof-of-concept for deep-tissue “photodynamic” therapy without external light source that can be considered as an alternative for traditional PDT.
Golgi phosphoprotein 3 induces autophagy and epithelial–mesenchymal transition to promote metastasis in colon cancer
Authors: Gong Li-Yun , Tu Ting , Zhu Jing , Hu Ao-Ping , Song Jun-Wei , Huang Jing-Qiang , Yang Yi , Zhu Zeyao , Chen Yu 
Published: February 2022

AbstractIn this study, we aimed to investigate whether and how Golgi phosphoprotein 3 (GOLPH3) facilitates colon cancer metastasis via the regulation of autophagy and epithelial–mesenchymal transition (EMT). The role GOLPH3 plays in colon cancer metastasis was analyzed using western blotting, immunohistochemistry, transwell, wound-healing, and zebrafish assays. Autophagy and EMT were assessed via RNA-sequencing (RNA-seq) analysis, mRFP-GFP-LC3 reporter assays, and their related markers. Significant associations were found between colon cancer clinical and pathological stages and poor prognosis. GOLPH3 facilitates colon cancer metastasis, both in vitro and in vivo. RNA-seq analysis of GOLPH3-overexpressing and control cell models revealed that GOLPH3 enhances EMT and autophagy. Moreover, examination of autophagic, epithelial, and mesenchymal markers in GOLPH3-overexpressing, -silenced, and control cell lines revealed that GOLPH3 promotes EMT and autophagy. When autophagy was inhibited, GOLPH3-promoted metastasis and EMT were counteracted in vitro and in vivo. Using RNA-seq, PI3K/Akt signaling was identified as the key downstream pathway on which GOLPH3 acts. Mechanistically, we demonstrated that GOLPH3 stimulates autophagy and induces EMT via the suppression of the phosphorylation of protein kinase B (Akt) at Ser473. In summary, GOLPH3 induces autophagy and EMT, promoting metastasis in colon cancer. Beyond this, and in contrast to conventional perspectives, we discovered that GOLPH3 represses the phosphorylation of Akt at Ser473.
Is contact-line mobility a material parameter?
Authors: Ludwicki Jonathan M. , Kern Vanessa R. , McCraney Joshua , Bostwick Joshua B. , Daniel Susan , Steen Paul H. 
Published: February 2022

AbstractDynamic wetting phenomena are typically described by a constitutive law relating the dynamic contact angle θ to contact-line velocity UCL. The so-called Davis–Hocking model is noteworthy for its simplicity and relates θ to UCL through a contact-line mobility parameter M, which has historically been used as a fitting parameter for the particular solid–liquid–gas system. The recent experimental discovery of Xia & Steen (2018) has led to the first direct measurement of M for inertial-capillary motions. This opens up exciting possibilities for anticipating rapid wetting and dewetting behaviors, as M is believed to be a material parameter that can be measured in one context and successfully applied in another. Here, we investigate the extent to which M is a material parameter through a combined experimental and numerical study of binary sessile drop coalescence. Experiments are performed using water droplets on multiple surfaces with varying wetting properties (static contact angle and hysteresis) and compared with numerical simulations that employ the Davis–Hocking condition with the mobility M a fixed parameter, as measured by the cyclically dynamic contact angle goniometer, i.e. no fitting parameter. Side-view coalescence dynamics and time traces of the projected swept areas are used as metrics to compare experiments with numerical simulation. Our results show that the Davis–Hocking model with measured mobility parameter captures the essential coalescence dynamics and outperforms the widely used Kistler dynamic contact angle model in many cases. These observations provide insights in that the mobility is indeed a material parameter.
Effectiveness of mRNA-1273 against SARS-CoV-2 Omicron and Delta variants
Authors: Tseng Hung Fu , Ackerson Bradley K. , Luo Yi , Sy Lina S. , Talarico Carla A. , Tian Yun , Bruxvoort Katia J. , Tubert Julia E. , Florea Ana , Ku Jennifer H. , Lee Gina S. , Choi Soon Kyu , Takhar Harpreet S. , Aragones Michael , Qian Lei 
Published: February 2022

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant is highly transmissible with potential immune escape. We conducted a test-negative case–control study to evaluate mRNA-1273 vaccine effectiveness (VE) against infection and hospitalization with Omicron or Delta. The large, diverse study population included 26,683 SARS-CoV-2 test-positive cases with variants determined by S gene target failure status (16% Delta and 84% Omicron). The two-dose VE against Omicron infection at 14–90 days was 44.0% (95% confidence interval, 35.1–51.6%) but declined quickly. The three-dose VE was 93.7% (92.2–94.9%) and 86.0% (78.1–91.1%) against Delta infection and 71.6% (69.7–73.4%) and 47.4% (40.5–53.5%) against Omicron infection at 14–60 days and >60 days, respectively. The three-dose VE was 29.4% (0.3–50.0%) against Omicron infection in immunocompromised individuals. The three-dose VE against hospitalization with Delta or Omicron was >99% across the entire study population. Our findings demonstrate high, durable three-dose VE against Delta infection but lower effectiveness against Omicron infection, particularly among immunocompromised people. However, three-dose VE of mRNA-1273 was high against hospitalization with Delta and Omicron variants.