bluuebunny/crossref_metadata_2025_split huggingface dataset:
Change in Oxidative Stress and Mitochondrial Dynamics in Response to Elevated Cold-Inducible RNA-Binding Protein in Cardiac Surgery-Associated Acute Kidney Injury
Authors: Zheng Xinglong , Fan Yang , Li Jing , Ma Tao , Li Yongxin , Wang Qian , Yan Yang , Liu Wenyan 
Published: July 2022

Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common yet serious complication that is closely related to cardiopulmonary bypass (CPB). Extracellular cold-inducible RNA-binding protein (eCIRP) can mediate aseptic inflammation and trigger intracellular oxidative stress. In the present study, expression of serum CIRP was significantly elevated post-CPB (

785.0
±
640.5

pg/mL vs.

149.5
±
289.1

pg/mL,

P
<
0.001

) and was positively correlated with CPB duration (

r
=
0.502

,

P
<
0.001

). Patients with high expression of CIRP had higher risks of postoperative AKI than patients with low CIRP expression (OR: 1.67, 95% CI 1.04-2.68). In a rat CPB model, the serum CIRP concentration increased significantly after CPB. Similarly, the levels of Scr and BUN significantly increased 4 hours after CPB. KIM-1 and NGAL mRNA levels in the CPB group were 8.2 and 4.3 times higher than the sham group, respectively. In addition, the levels of inflammatory cell infiltration, oxidative stress, and apoptosis in the renal tissue of the CPB group were significantly higher compared to the sham group. The expression levels of serum inflammatory factors at 4 hours post-CPB were also increased. Administration of recombinant human CIRP protein promoted the expression of NADPH oxidase via the TLR-4/MyD88 pathway, aggravated intracellular oxidative stress, mediated mitochondrial dynamics disorder, and eventually increased apoptosis in HK-2 cells. However, the CIRP inhibitor C23 improved the CIRP-mediated oxidative stress and mitochondrial dysfunction in both rat and cell models. In summary, elevated CIRP could mediate oxidative stress and mitochondrial dynamics in the kidney to promote CSA-AKI.
The Comparison of Clinical Efficacy of Minimally Invasive Tarsal Sinus Approach and L-Type Incision Approach Combined with 3D Printing Technology in Calcaneal Fracture
Authors: Du Hao , Li Shiang , Tu Shicheng , Wang Kun , Fang Zhiyu 
Published: July 2022

Purpose. To explore the comparison of the reduction of the subtalar articular surface and other postoperative effects of the minimally invasive tarsal sinus approach and lateral L-shaped incision conventional approach for the treatment of calcaneal fracture with 3D printing technology. Methods. Patients who received surgical treatment for calcaneal fractures in the First Affiliated Hospital of Henan University of Science and Technology from June 2019 to December 2020 were collected. 3D printing equipment produced the affected side reduction heel bone fracture model and navigation template model. The tarsal sinus approach was used in the experimental group, and the lateral L-shaped incision approach was used in the control group. Patients were followed up 3 days, 1 month, 3 months, 6 months, and 12 months after the operation. Imaging indicators were measured 12 months after surgery, and scores from American Foot and Ankle Orthopaedic Society (AOFAS) and MSF were performed. Results. Operation time was

70.52
±
13.16

in the control group and

55.24
±
12.25

minutes in the experimental group (

P
<
0.001

). Intraoperative blood loss was

98.77
±
18.65

in the control group and

89.56
+
17.54

in the experimental group (

P
>
0.05

). The duration of antibiotic use was

5.53
±
3.24

days in the control group and

5.48
±
4.18

days in the experimental group (

P
>
0.05

). The frequency of fluoroscopy was

6.56
±
1.72

in the control group and

3.88
±
1.05

in the experimental group (

P
<
0.001

). Fracture healing time was

3.24
±
0.52

months in the control group and

3.08
±
0.58

months in the experimental group (

P
>
0.05

). The postoperative Böhler angle was

28.31
±
3.14

in the control group and

29.24
±
2.76

in the experimental group (

P
>
0.05

). Postoperative subtalar articular displacement (

step
>
2

mm) was observed in 4 patients in the control group and 1 in the experimental group (

P
<
0.05

). MSF score was

90.12
±
4.85

in the control group and

91.36
±
2.58

in the experimental group (

P
>
0.05

). Conclusion. The study found that the experimental group was significantly better than the control group in terms of the operation time, intraoperative fluoroscopy times, and success rate of reduction of the subtalar articular surface. 3D printing technology can shorten the operation time, accurately reduce the fracture block, and reduce the secondary trauma, which is conducive to the functional recovery of the affected foot.
Individual and Joint Effects of Influenza-Like Illness and Vaccinations on Stroke in the Young: A Case-Control Study
Authors: Vollmer Brandi L. , Solowey Julia , Chen Xing , Chang Bernard P. , Williams Olajide , Kulick Erin R. , Elkind Mitchell S.V. , Boehme Amelia K. 
Published: July 2022

Background:
Influenza-like illness (ILI) is an acute trigger for stroke, although joint effects of vaccinations and ILI have not yet been explored.

Methods:

Data for our case-control study was obtained from MarketScan Commercial Claims and Encounters between 2008 and 2014. Patients 18 to 65 years old who experienced a stroke were matched on age and admission date to a control, defined as patients with head trauma or ankle sprain at an inpatient or emergency department visit. Exposures were ILI in the prior 30 days, and any type of vaccination during the year prior. Our outcome was ischemic and intracerebral hemorrhagic strokes identified using
International Classification of Diseases, Ninth Revision (ICD-9
) codes. Logistic regression models estimated adjusted odds ratios (aORs) controlling for preventive care visits, diabetes, valvular heart disease, smoking, alcohol abuse, obesity, and hypertension.

Results:

We identified and matched 24 103 cases 18 to 44 years old and 141 811 45 to 65 years old. Those aged 18 to 44 years had increased stroke risk 30 days after ILI (aOR, 1.68 [95% CI, 1.51–1.86]) and reduced risk with any vaccination in the year prior (aOR, 0.92 [95% CI, 0.87–0.99]). Joint effects indicate that ILI was associated with increased stroke risk among those with (aOR, 1.41 [95% CI, 1.08–1.85]) and without (aOR, 1.73 [95% CI, 1.55–1.94]) vaccinations in the prior year (
P
interaction
=0.16). Among those aged 45 to 65 years, adjusted analyses indicate increased stroke risk for those with ILI (aOR, 1.32 [95% CI, 1.26–1.38]), although there was no effect of vaccinations (aOR, 1.00 [95% CI, 0.97–1.02]). Joint effects indicate that ILI was not associated with stroke among those with any vaccination (aOR, 1.07 [95% CI, 0.96–1.18]) but was associated with increased risk among those without vaccinations ([aOR, 1.39 [95% CI, 1.32–1.47];
P
interaction
<0.001).

Conclusions:
ILI was associated with increased stroke risk in the young and middle-aged, while vaccinations of any type were associated with decreased risk among the young. Joint effects of ILI and vaccinations indicate vaccinations can reduce the effect of ILI on stroke.
Police, ambulance and psychiatric co-response versus usual care for mental health and suicide emergency callouts: A quasi-experimental study
Authors: Every-Palmer Susanna , Kim Alice Hyun Min , Cloutman Lauren , Kuehl Silke 
Published: July 2022

Objective: Mental health–related calls to emergency services made via 111 (New Zealand) or 000 (Australia) often represent critical junctures for the person in crisis. Traditionally, police, ambulance and mental health services work separately to manage such emergencies. Sequential agency responses may be protracted and cause escalation. This study tests multi-agency co-response aiming for more integrated, faster, safer and less coercive management of mental health crises. Methods: Immediate and 1-month outcomes of mental health emergency calls made to police and ambulance were compared according to whether they occurred on days with co-response availability. Outcomes measured included emergency department admission and waiting times, psychiatric admissions, compulsory treatment, use of force, detention in police cells and the time to resolution of the event. Relative risk estimates were constructed. Results: A total 1273 eligible mental health emergency callouts occurred between March 2020 and March 2021 (38% coded ‘mental health’ emergencies, 48% suicide risk and 14% as ‘other’), 881 on days with co-response availability and 392 on days without. Co-response interventions were resolved faster and were more likely to be community-based. Fewer than one-third (32%) led to emergency department admissions, compared with close to half (45%) on days without co-response (risk ratio: 0.7 [0.6, 0.8]). In the following month, the number of emergency department and mental health admissions reduced ( p < 0.01 and 0.05, respectively). There were no statistically significant differences in use of force and few people were detained in police custody. Conclusion: Co-response intervention increased the likelihood of mental health crises being resolved in the community and reduced hospitalisations. Benefits were sustained at 1 month.
Theorizing Racist Ableism in Higher Education
Authors: Mireles Danielle 
Published: July 2022

Background/Context: Although research on the experiences of multiply-marginalized Black and Brown students with dis/abilities in higher education is limited, this growing body of work indicates that these students navigate racialized perceptions of ability, which impact their experiences on college and university campuses. This research highlights the need for intersectional frameworks that consider students’ multiple identities and the limitations of single-identity–focused frameworks. Purpose/Objective/Research Question/Focus of Study: Centering the counternarratives of 10 Black and Brown undergraduate students with dis/abilities across five college and university campuses, this article uses critical race theory (CRT), disability critical race theory (DisCrit), and racist nativism to develop a conceptual framework of racist ableism. Racist ableism bridges CRT, DisCrit, and racist nativism to describe how particular forms of ableism, informed by racist attitudes and beliefs, oppress and dehumanize Black and Brown people based on actual or perceived (or, inversely, lack of perceived) dis/ability, thereby reinforcing the relationship between whiteness and ability. Research Design: I examined the counternarratives of 10 Black and Brown undergraduate students who identified or have the lived experience of dis/ability. Counternarratives allowed me to center the stories of students. I identify three overarching findings: (1) Black and Brown dis/abled students navigated racialized perceptions of intelligence, productivity, and academic capability; (2) Black and Brown dis/abled students were pathologized as lazy and/or deviant, which minimized or erased their access needs; and (3) Black and Brown dis/abled students resisted racist ableist discourses. Conclusions/Recommendations: The counternarratives of students reveal how racialized perceptions of ability shaped their experiences interacting with staff and their ability to access institutional supports such as accommodations. They also reveal the critical raced-disabled epistemologies of Black and Brown students who identify or have been labeled as dis/abled. Their counternarratives highlight the need for: (1) intersectional frameworks that account for the ways in which racism and ableism are interconnected, and (2) race-conscious policies and practices that consider their multidimensional identities.
How Do Marital Transitions Affect Self-Perceptions of Aging?
Authors: Turner Shelbie G. , Witzel Dakota D. , Stawski Robert S. , Hooker Karen 
Published: July 2022

Objectives We analyzed whether marital status and experiences of marital loss or gain were associated with self-perceptions of aging (SPA), a major psychosocial mechanism of healthy aging. Method We used data from 7028 participants of the Health and Retirement Study. Participants reported their marital status and their positive and negative SPA on two occasions 4 years apart. We ran general linear models to analyze differences in SPA between men and women who remained married, became divorced or widowed, or remarried following divorce or widowhood. Results Participants who experienced marital loss had lower positive SPA than participants who remained marred. Participants who experienced marital gain had lower negative SPA than participants who remained married. None of the associations differed between men and women. Discussion Results suggest that it may not be marital status itself, but rather the transition into or out of marriage, that impacts how people appraise their own aging.
Association between the loudness dependence of auditory evoked potentials and age in patients with schizophrenia and depression
Authors: Jang Kuk-In , Kim Sungkean , Lee Chany , Chae Jeong-Ho 
Published: July 2022

Objective Although serotonergic dysfunction is significantly associated with major depressive disorder (MDD) and schizophrenia (SCZ), comparison of serotonergic dysfunction in both diseases has received little attention. Serotonin hypotheses have suggested diminished and elevated serotonin activity in MDD and SCZ, respectively. However, the foundations underlying these hypotheses are unclear regarding changes in serotonin neurotransmission in the aging brain. The loudness dependence of auditory evoked potentials (LDAEP) reflects serotonin neurotransmission. The present study compared the LDAEP between patients with SCZ or MDD and healthy controls (HCs). We further examined whether age was correlated with the LDAEP and clinical symptoms. Methods This prospective clinical study included 105 patients with SCZ (n = 54) or MDD (n = 51). Additionally, 35 HCs were recruited for this study. The LDAEP was measured on the midline channels via 62 electroencephalography channels. Results Patients with SCZ or MDD showed a significantly smaller mean LDAEP than those in HCs. The LDAEP was positively correlated with age in patients with SCZ or MDD. Conclusions Changes in central serotonergic activity could be indicated by evaluating the LDAEP in patients with SCZ or MDD. Age-related reductions in serotonergic activity may be screened using the LDAEP in patients with SCZ or MDD.
Why services cannot be the engine of growth for India
Authors: Talreja Chaitanya , Dasgupta Anirban 
Published: July 2022

AbstractIndia’s phenomenal service-led growth in recent decades has generated debate on the role of services vis-à-vis manufacturing as the engine of growth. With the rapidly increasing importance of Information and Communication Technology (ICT) in global production systems since the 1990s, there have been claims of services having developed a growth dynamism similar to manufacturing. This article examines the role of services in India’s growth process using the concept of inter-sectoral linkages to make comparison with the role of manufacturing. Input-Output linkages and time series analysis reveal that services have been much less integrated in India’s production structure than manufacturing. They were also less important in generating indirect employment spillovers through sectoral linkages, compared with manufacturing. Service sector growth is found to be autonomously driven by final demand and therefore less dependent on its interconnections with the rest of the economy from the production side. The findings also indicate that service sector growth has stimulated manufacturing growth but not vice versa. However, the impact of services on manufacturing from the demand-side is neither sustainable nor desirable going forward. India is in urgent need of strategically developing its manufacturing sector through integrating dynamic services like ICT and internalising productivity gains. At the same time measures to address India’s inequality are critical to broaden the country’s demand base and make the growth process more sustainable and inclusive. In this sense, inequality reduction is a prerequisite for growth and should not be seen as an alternative to it.
Influence of rail weld irregularity on dynamic stress of bogie frame based on vehicle-track rigid-flexible coupled model
Authors: Sun Yi , Wei Lai , Dai Huanyun , Liu Chaotao , Qu Sheng , Qi Yayun 
Published: July 2022

To examine the effects of rail weld irregularity on the dynamic stress of the bogie frame, a numerical model which considers the bogie frame flexibility is established. Field measurements were conducted to validate the reliability of the proposed model and the bogie frame’s modal vibration including the bending deformation of cross beams at 50 Hz can be observed. A comparison between the flexible bogie frame model and the traditional multi-body dynamics model is conducted to investigate the influences of the bogie frame’s flexibility on wheel-rail interactions. Then the numerical model of the rail weld joint is proposed to study the P2 resonance performance and the dynamic stress patterns of the bogie frame. A comparison of influences with different rail weld irregularities and parameter studies are conducted. Then the effects of fastener stiffness on P2 resonance frequencies are discussed. The results show that it is necessary to consider the bogie frame’s flexibility in simulations which will aggravate the wheel-rail vibrations. The short wavelengths in combination with a certain speed could induce the bogie frame’s modal vibration and large track supporting stiffness will threaten the running safety of the vehicle which may also contribute to the formation of wheel out-of-roundness. Besides, the limit values of the rail weld irregularities are discussed to provide a reference for rail surface grinding from different aspects.
Surgical removal of submacular choroidal neovessels in children: Outcome and literature review
Authors: Abdelmassih Youssef , EL Khoury Sylvain , Dureau Pascal , Edelson Catherine , Metge Florence , Caputo Georges 
Published: July 2022

Purpose To report on the outcome of surgical submacular choroidal neovascular membrane (CNV) removal in children and to perform a comprehensive review of literature concerning this intervention in children. Methods In this retrospective, noncomparative, interventional case series, we included 8 eyes of 7 consecutive children with subfoveal choroidal neovascularization treated by pars plana vitrectomy (PPV) and CNV removal. Main outcome measures were visual acuity and complications. Results Mean age at surgery was 8.6 ± 5.2 years (range: 2–16). Two out of 8 eyes were idiopathic. Corrected-distance visual acuity (CDVA) improved from 1.01 ± 0.45logMAR (range:0.3–1.5) at presentation to 0.60 ± 0.37 (range:0–1) at last follow-up (p = 0.03). Mean follow-up was 3.9 ± 3.9 years. Six eyes received at least one intravitreal injection of bevacizumab prior to surgery. Recurrence occurred in one eye with Best's disease. Literature review revealed a total of 42 cases with the most frequent etiologies being Presumed ocular histoplasmosis syndrome (POHS) and idiopathic CNV. Considering all cases together, mean CDVA improved from 1.00 ± 0.37logMAR to 0.52 ± 0.42 (p < 0.01). CNV recurrence occurred in 11 eyes (22.0%), 7 of which had an inflammatory etiology. Other complications included pigment epithelium tear, atrophy and retinal tear. Conclusion Surgical removal of CNV is a viable, effective and safe option in children with persistent submacular neovascular membranes.
The experiences and perceptions of young people and older people living with dementia of participating in intergenerational programmes: A qualitative evidence synthesis
Authors: Houghton Catherine , Hennessy Marita , Smyth Siobhán , Hennelly Niamh , Smalle Michael , Jordan Fionnuala , Jones Catrin H. , Quinn Michelle , Casey Dympna , Teahan Áine 
Published: July 2022

Background Intergenerational programmes are formal activities bringing different generations together and have been identified as a way to help people living with dementia to stay socially connected. While there is some evidence from individual studies as to their benefits, there is no overall coherent account as to the perceptions and experiences of participants who engage in such programmes. This review synthesises qualitative evidence of the experiences and perceptions of young people and older people living with dementia of participating in such programmes. Methods We searched EBSCO CINAHL, OVID Medline, Embase, Ovid PsycINFO, the Web of Science, Epistemonikos and grey literature sources. We used thematic synthesis to analyse and synthesise the evidence in to four themes, with 11 key findings. We assessed our confidence in each of these findings using the GRADE-CERQual (Confidence in the Evidence from Reviews of Qualitative research) approach. Findings Our review highlights the potential enjoyment for young people and older people living with dementia when participating in Intergenerational programmes, despite some initial trepidation. These programmes provide an opportunity to establish and develop relationships and for young people to learn about dementia, ageing and how to interact with older people living with dementia. However, it is important to have staff facilitators present to provide reassurance to both groups. It is also important to take the personal preferences of participants into account and to be considerate of noise levels and other aspects of programme delivery that may inhibit engagement. Conclusion This is the first qualitative evidence synthesis specifically exploring Intergenerational programmes aimed at older people living with dementia. We provide insights into the perspectives of those who have participated in Intergenerational programmes. It is important to consider these views, together with other evidence of effectiveness, when planning Intergenerational programmes. While our review is limited by a small number of studies from only a few countries, we have moderate to high confidence in our findings. Further research into the development of Intergenerational programmes specifically tailored for people living with dementia is needed. The findings also provide guidance for people planning to deliver or design future Intergenerational programmes.
Conduit/Wrap Repairs to Digital Nerves Provide Residual Strength After Peak Loading
Authors: Tavitas Grace E. , Schimoler Patrick J. , Kharlamov Alexander , Tang Peter , Miller Mark Carl 
Published: July 2022

Background: Many techniques are used for digital nerve repair, most commonly coaptation by sutures. Nerve repairs must be strong while offering an environment for nerve regeneration. Sutures can damage the nerve and thereby limit growth and regeneration. Sutures can rip and cause sudden catastrophic failure. Fibrin glue and conduit-wraps allow a good environment for growth, but neither provides much strength. A benefit to conduit repair would arise if the repair maintained integrity after the peak load so that the path for regrowth stayed in place. The goal for this study was to determine whether conduit with glue provides continued strength after a maximum load is reached. Methods: Digital cadaveric nerves were harvested and repaired with 2 epineurial sutures, conduit, and fibrin glue in all combinations. Tests to failure were performed, gap displacement between nerve ends recorded, and the postpeak load energy to dissociation of the nerve and conduit was calculated. Results: Conduit with glue and 2 sutures at the end had the greatest energy and displacement after the peak load but was not significantly different than conduit with glue and 1 suture. Conduit with glue alone obtained statistically the same displacement as conduit with glue and 2 sutures. Conduit, with or without glue, and 2 sutures was statistically the same as suture only repair for peak load. Conclusion: Conduit/wrap maintains a load capacity and a path for nerve regeneration after the peak. Suture at the ends of conduit, not at the coaptation site, reduces damage at the point of injury.