bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploiting the legacy of N.N. Ambraseys: known and unknown earthquakes in the Anatolian area
Authors: Stucchi M. , Sesetyan K. , Augusto Antonio Gomez Capera , Sbeinati M. R. 
Published: August 2022

AbstractN.N. Ambraseys left us a wealth of papers and volumes on a number of topics; many of them concern the historical earthquake investigation. One of the last works is the 2009 volume (Ambraseys in Earthquakes in the Eastern Mediterranean and the Middle East: a multidisciplinary study of 2000 years of seismicity, Cambridge, Cambridge, UK, 2009), where he summarizes the results of more than thirty years of investigation through archives and libraries, covering earthquakes of a large area, from Albania to Caucasus. For each earthquake, a short summary of the main effects is supplied, together with the list of the sources used. Such information is intended as material for assessing location and size of the earthquakes, task that the author accomplished only in a very preliminary way for a few earthquakes, only. In addition to exhaustive descriptions of the most known earthquakes and the relevant historical sources, the volume contains information on a large number of earthquakes, so far unknown to the current earthquake catalogues. This paper intends to represent a homage to his immense work, partially showing the potential of his volume. We briefly present here some case histories, including the preliminary location and size of the earthquakes – known and unknown—around Anatolia. We add some examples of how he was able to prove that some alleged earthquakes are actually to be considered as fake or very doubtful. We also present the damage information supplied for some known and unknown earthquakes, and how they can be used for assessing location and size of them.
Epidermal growth factor receptor (EGFR) expression in high grade glioma and relationship with histopathologic findings, a cross sectional study
Authors: Miratashi Yazdi Seyed Amir , Bakhshi Niousha , Nazar Elham , Tabriz Hedieh Moradi , Gorji Reza 
Published: August 2022

ABSTRACT

Introduction:
There are some evidences for the relationship between the expression of epidermal growth factor receptor (EGFR) gene and the clinical and histopathological behavior of the high grade glioma. However, such a relationship can take quite different forms in different societies. We aimed to evaluate the EGFR expression status in high grade of glioma and its relationship with histopathological patterns in the tumor.

Methods:
We studied the immunohistochemichal expression of EGFR in 30 brain surgical resection specimens with different high grades. All samples were from pathology department of Sina Hospital in Tehran-Iran from 2020 to 2021.

Results:
EGFR positivity was reported in 56.6% of all tissue samples assessed. The assessment of relationship between EGFR expression and baseline and tumor characteristics showed no significant association of EGFR expression and patients’ gender, age, tumor location, tumor size, its type, grade, and also existence of necrosis (P value > 0.05).

Conclusion:
EGFR expression can be found in about half of our patients suffering high grade glioma. The over-expression of EGFR seems to be independent to demographic characteristics. Also, over-expression of EGFR may not predict the presence of necrosis in tumor tissue.

Highlights
Morphodynamics of wave-dominated beaches
Authors: Castelle Bruno , Masselink Gerd 
Published: August 2022

AbstractWave-dominated sandy beaches are highly valued by societies and are amongst the world’s most energetic and dynamic environments. On wave-dominated beaches with unlimited sand supply and limited influence of tide and geology, beach change has long been conceptualised in the morphodynamic framework of Wright and Short (1984). Such framework describes the occurrence of beach types based on wave conditions and sediment characteristics across the complete reflective–dissipative spectrum. Building on theoretical work, field/laboratory measurements and monitoring programmes, the physical mechanisms underpinning this morphodynamic framework have been progressively unravelled. Cross-shore morphological changes are primarily controlled by equilibrium and beach memory principles with below (above) average wave conditions driving down-state (up-state) transitions associated with onshore (offshore) sediment transport. Such cross-shore behaviour mostly reflects the imbalance between the onshore-directed sediment transport driven by wave nonlinearities and the offshore-directed sediment transport driven by the undertow. Self-organised morphological instabilities resulting from different positive feedback mechanisms are primarily responsible for alongshore morphological variability and the generation of rhythmic morphological features, such as crescentic bars, rip channels and beach cusps. Critically, wave climate and changes in wave regimes are key in driving the coupled cross-shore and longshore behaviour that ultimately explains modal beach state and frequency-response characteristics of beach morphological time series.
Costs of common perinatal mental health problems in South Africa
Authors: Bauer Annette , Garman Emily , Besada Donela , Field Sally , Knapp Martin , Honikman Simone 
Published: August 2022

AbstractBackgroundPerinatal mental health problems, defined as mental health problems occurring from the start of pregnancy to one year after birth, substantially affect women's and children's quality of life in low- and middle-income countries. In South Africa, despite high prevalence and documented negative impacts, most women do not receive any care.MethodsA modelling study examined the costs of perinatal mental health problems, namely depression and anxiety, for a hypothetical cohort of women and their children in South Africa over part of their life course (10 years for women, 40 years for children). In sensitivity analysis, additional impacts of post-traumatic stress disorder (PTSD) and completed suicide were included. Data sources were published findings from cohort studies, as well as epidemiological and economic data from South Africa. Data from international studies were considered where no data from South Africa were available.ResultsLifetime costs of perinatal depression and anxiety in South Africa amount to USD 2.8 billion per annual cohort of births. If the impacts of PTSD and suicide are included, costs increase to USD 2.9 billion. This includes costs linked to losses in quality of life (USD 1.8 billion), losses in income (USD 1.1 billion) and public sector costs (USD 3.5 million).ConclusionsWhilst important progress has been made in South Africa with regards to mental health policies and interventions that include assessment and management of perinatal mental health problems, substantial underinvestment prevents progress. Findings from this study strengthen the economic case for investing in perinatal mental health care.
A randomized trial to determine whether wearing slippers reduces transfer of bacteriophage MS2 from floors to patients and surfaces in hospital rooms
Authors: Haq Muhammed F. , Alhmidi Heba , Redmond Sarah N. , Cadnum Jennifer L. , Silva Sandra Y. , Wilson Brigid M. , Donskey Curtis J. 
Published: August 2022

AbstractIn a randomized trial, patients wearing slippers whenever out of bed transferred bacteriophage MS2 from hospital room floors to patients and surfaces significantly less often than controls not provided with slippers. Wearing slippers could provide a simple means to reduce the risk for acquisition of healthcare-associated pathogens from contaminated floors.Registration: ClinicalTrials.gov; NCT04935892
Is the number of prescriptions an appropriate metric for outpatient antimicrobial consumption? A comparison between the prescription counts and days supplied
Authors: Kakiuchi Satoshi , Perencevich Eli N. , Livorsi Daniel J. , Goto Michihiko 
Published: August 2022

AbstractThe optimal metric for outpatient antimicrobial stewardship has not been well defined. The number of antibiotic prescriptions per clinic visit does not account for the therapeutic duration. We found only moderate association between prescription-based metrics and days-supplied–based metrics. Outpatient antibiotic consumption metrics should incorporate the duration of therapy.
“The People Do Not Understand”: R. Ḥayim Hirschensohn and Political Elitism in Modern Judaism (The Vilna Gaon, Rabbi N.Ts.Y. Berlin, I. B. Levinsohn, and Herzl)
Authors: Brown Benjamin 
Published: August 2022

AbstractRabbi Ḥayim (Chaim) Hirschensohn (1857–1935) was one of only a handful of Jewish thinkers to work out a Jewish political theology, and on account of his progressive stances he became a favorite of liberal circles within contemporary Judaism. Therefore, a passage in his book Malki Bakodesh, in which he expresses clear opposition to universal suffrage, “invited” mitigating interpretations. Yet, a survey of Hirschensohn’s various writings reveals that they contain a trend of political elitism. Is this surprising? Hirschensohn’s progressiveness notwithstanding, the article argues that his elitist sentiments are rooted in three major intellectual trends within modern Judaism: Mitnagdism, Haskalah, and Zionism. In the writings of seminal thinkers in each of these movements, we find political elitism and reservations about government “by the people.” Hirschensohn’s personal history positioned him at the confluence of these trends, and so his elitist opinions should be viewed as the outgrowth of these intellectual traditions.
The complete mitogenome of the Asian lung fluke Paragonimus skrjabini miyazakii and its implications for the family Paragonimidae (Trematoda: Platyhelminthes)
Authors: Le Thanh Hoa , Nguyen Khue Thi , Pham Linh Thi Khanh , Doan Huong Thi Thanh , Agatsuma Takeshi , Blair David 
Published: August 2022

AbstractThe complete circular mitogenome of Paragonimus skrjabini miyazakii (Platyhelminthes: Paragonimidae) from Japan, obtained by PacBio long-read sequencing, was 17 591 bp and contained 12 protein-coding genes (PCGs), 2 mitoribosomal RNA and 22 transfer RNA genes. The atp8 gene was absent, and there was a 40 bp overlap between nad4L and nad4. The long non-coding region (4.3 kb) included distinct types of long and short repeat units. The pattern of base usage for PCGs and the mtDNA coding region overall in Asian and American Paragonimus species (P. s. miyazakii, P. heterotremus, P. ohirai and P. kellicotti) and the Indian form of P. westermani was T > G > A > C. On the other hand, East-Asian P. westermani used T > G > C > A. Five Asian and American Paragonimus species and P. westermani had TTT/Phe, TTG/Leu and GTT/Val as the most frequently used codons, whereas the least-used codons were different in each species and between regional forms of P. westermani. The phylogenetic tree reconstructed from a concatenated alignment of amino acids of 12 PCGs from 36 strains/26 species/5 families of trematodes confirmed that the Paragonimidae is monophyletic, with 100% nodal support. Paragonimus skrjabini miyazakii was resolved as a sister to P. heterotremus. The P. westermani clade was clearly separate from remaining congeners. The latter clade was comprised of 2 subclades, one of the East-Asian and the other of the Indian Type 1 samples. Additional mitogenomes in the Paragonimidae are needed for genomic characterization and are useful for diagnostics, identification and genetic/ phylogenetic/ epidemiological/ evolutionary studies of the Paragonimidae.
Bain's Theory of Moral Judgment and the Development of Mill's Utilitarianism
Authors: Zimmerman Aaron 
Published: August 2022

AbstractInUtilitarianism, Mill defers to Alexander Bain's expertise on the subject of moral judgment to answer common criticisms of the creed. First, we do not blame people or label them immoral when they are less than ideal. Judgments of immorality are commonly reserved for substandard behavior, not suboptimal comportment. Second, we do not commonly insist on full neutrality in benevolence. Indeed, some philosophers argue that we are obliged to exhibit partiality, insofar as it is demanded by our roles as friends, parents, or children. My primary aim in this essay is to explicate Bain's theory of moral judgment and explain how Mill used Bain's psychological doctrines to inform his development of an indirect utilitarian moral philosophy, immune to the criticisms described above.
1751 and Thereabout: A Quantitative and Comparative Approach to Notarial Records
Authors: Lemercier Claire , Trivellato Francesca 
Published: August 2022

AbstractThis article asks a simple question that nevertheless has broad implications for historians of premodern continental Europe: What did notaries do? It answers it by applying descriptive statistics, principal component analysis, and clustering techniques to the typological distribution of all deeds preserved in the notarial collections of six French and Italian cities—Paris, Toulouse, Mende, Turin, Florence, and Livorno—for the year 1751, as well as smaller datasets for other dates and locations. The results of this analysis are surprising. In spite of a high degree of consistency in the notarial profession and terminology (a trait that facilitates our comparisons), the notarial style of each city varied greatly. Variations within a single state were sometimes greater than those across state borders. Both supply and demand of notarial services differed from city to city. Overall, our conclusions are as important as the methodology that we adopt to reach them. Our aim is to offer a replicable analysis that puts quantitative methods in the service not only of the study of a source (notarial records) that is widespread across late medieval and early modern continental Europe and its overseas empires but also of a renewed comparative social history that does not shy away from the heterogeneity of primary sources.
Effects of different application methods of spent coffee grounds on weed growth
Authors: Hirooka Yoshihiro , Kurashige Shintaro , Yamane Koji , Kakiuchi Misako , Miyagawa Taku , Iwai Kazuya , Iijima Morio 
Published: August 2022

AbstractThe extensive and intensive use of herbicides has resulted in the spread of herbicide-resistant weeds in many crop production systems; therefore, it is imperative to devise new organic weed control methods. Recently, the application of spent coffee grounds (SCG) in agricultural fields has been found to inhibit plant growth and germination and is thus considered a potentially effective weed control measure. This study aimed to evaluate the effects of different amounts and methods of SCG application on weed growth through field experiments. The field experiments were conducted in an upland field converted from a paddy in western Japan. The results show that the plow-in application of over 10 kg m−2 of SCG and mulching application of 20 kg m−2 decreased the weed dry weight compared with the control. In addition, the growth of weed species of families other than Gramineae, such as wingleaf primrose-willow and horseweed, was not significantly affected by SCG application. Weed species of families other than Gramineae are dominant in some upland fields. Hence, the inhibitory effect of SCG on weeds may be lower in original upland fields than in the upland field converted from paddy field that was investigated in the present study. Overall, this study demonstrated that the plow-in application of 10 kg m−2 of SCG every 4 mo was effective for weed control in an upland field converted from a paddy field. Because SCG worked against grass weeds under the specific conditions in this study, it would be valuable to explore other potential applications of this novel means of weed control.
The Initiation and Growth of Transpressional Shear Zones Through Continental Arc Lithosphere, Southwest New Zealand
Authors: Klepeis Keith A. , Schwartz Joshua J. , Miranda Elena , Lindquist Peter , Jongens Richard , Turnbull Rose , Stowell Harold 
Published: August 2022

AbstractStructural analyses combined with new U‐Pb zircon and titanite geochronology show how two Early Cretaceous transpressional shear zones initiated and grew through a nearly complete section of continental arc crust during oblique convergence. Both shear zones reactivated Carboniferous faults that penetrated the upper mantle below Zealandia's Median Batholith but show opposite growth patterns and dissimilar relationships with respect to arc magmatism. The Grebe‐Indecision Creek shear zone was magma‐starved and first reactivated at ∼136 Ma as an oblique‐reverse fault, along which an outboard batholith partially subducted beneath Gondwana. This system nucleated at or above ∼20 km depth and propagated downward at 2–3 mm yr−1, accumulating at least 35–45 km of horizontal (arc‐normal) shortening by ∼124 Ma. In contrast, the magma‐rich George Sound shear zone first reactivated in the lower crust (∼55 km depth) at ∼124 Ma and grew upward at ∼3 mm yr−1, reaching the upper crust by ∼110 Ma. In this latter system, magmatism influenced shear zone architecture and drove its growth while subduction and oblique convergence ended. As magma entered the roots of the system and began to solidify, deformation was driven out of the lower crust and into the middle crust where the system widened by a factor of three when fold‐thrust belts formed on either side of a steep, central transpressional shear zone. This study illustrates how the reactivation of structural weaknesses localizes deformation at all depths in the lithosphere and shows how magma‐deformation feedbacks influence shear zone connectivity and built a batholith from the bottom up.
Crizotinib attenuates cancer metastasis by inhibiting TGFβ signaling in non-small cell lung cancer cells
Authors: Park Soonbum , Cho Eun A , Chun Jung Nyeo , Lee Da Young , Lee Sanghoon , Kim Mi Yeon , Bae Sang Mun , Jo Su In , Lee So Hee , Park Hyun Ho , Kim Tae Min , So Insuk , Kim Sang-Yeob , Jeon Ju-Hong 
Published: August 2022

AbstractCrizotinib is a clinically approved tyrosine kinase inhibitor for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring EML4-ALK fusion. Crizotinib was originally developed as an inhibitor of MET (HGF receptor), which is involved in the metastatic cascade. However, little is known about whether crizotinib inhibits tumor metastasis in NSCLC cells. In this study, we found that crizotinib suppressed TGFβ signaling by blocking Smad phosphorylation in an ALK/MET/RON/ROS1-independent manner in NSCLC cells. Molecular docking and in vitro enzyme activity assays showed that crizotinib directly inhibited the kinase activity of TGFβ receptor I through a competitive inhibition mode. Cell tracking, scratch wound, and transwell migration assays showed that crizotinib simultaneously inhibited TGFβ- and HGF-mediated NSCLC cell migration and invasion. In addition, in vivo bioluminescence imaging analysis showed that crizotinib suppressed the metastatic capacity of NSCLC cells. Our results demonstrate that crizotinib attenuates cancer metastasis by inhibiting TGFβ signaling in NSCLC cells. Therefore, our findings will help to advance our understanding of the anticancer action of crizotinib and provide insight into future clinical investigations.
DNA methylome and single-cell transcriptome analyses reveal CDA as a potential druggable target for ALK inhibitor–resistant lung cancer therapy
Authors: Heo Haejeong , Kim Jong-Hwan , Lim Hyun Jung , Kim Jeong-Hwan , Kim Miso , Koh Jaemoon , Im Joo-Young , Kim Bo-Kyung , Won Misun , Park Ji-Hwan , Shin Yang-Ji , Yun Mi Ran , Cho Byoung Chul , Kim Yong Sung , Kim Seon-Young , Kim Mirang 
Published: August 2022

AbstractAcquired resistance to inhibitors of anaplastic lymphoma kinase (ALK) is a major clinical challenge for ALK fusion-positive non-small-cell lung cancer (NSCLC). In the absence of secondary ALK mutations, epigenetic reprogramming is one of the main mechanisms of drug resistance, as it leads to phenotype switching that occurs during the epithelial-to-mesenchymal transition (EMT). Although drug-induced epigenetic reprogramming is believed to alter the sensitivity of cancer cells to anticancer treatments, there is still much to learn about overcoming drug resistance. In this study, we used an in vitro model of ceritinib-resistant NSCLC and employed genome-wide DNA methylation analysis in combination with single-cell (sc) RNA-seq to identify cytidine deaminase (CDA), a pyrimidine salvage pathway enzyme, as a candidate drug target. CDA was hypomethylated and upregulated in ceritinib-resistant cells. CDA-overexpressing cells were rarely but definitively detected in the naïve cell population by scRNA-seq, and their abundance was increased in the acquired-resistance population. Knockdown of CDA had antiproliferative effects on resistant cells and reversed the EMT phenotype. Treatment with epigenome-related nucleosides such as 5-formyl-2′-deoxycytidine selectively ablated CDA-overexpressing resistant cells via accumulation of DNA damage. Collectively, our data suggest that targeting CDA metabolism using epigenome-related nucleosides represents a potential new therapeutic strategy for overcoming ALK inhibitor resistance in NSCLC.
Integrative tumour mutation burden with CD39 and PD-L1 for the prediction of response to PD-L1 blockade and adjuvant chemotherapy in muscle-invasive bladder cancer patients
Authors: Liu Chunnan , Liu Zhaopei , Jin Kaifeng , Zeng Han , Shao Fei , Chang Yuan , Wang Yiwei , Xu Le , Wang Zewei , Zhu Yu , Zhang Weijuan 
Published: August 2022

Abstract
Background
CD39, a rate-limiting enzyme to convert extracellular ATP (eATP) to adenosine, has been reported to be a key modulator of immune response, but its correlation with therapeutic sensitivity remains obscure. We conducted this study to determine whether the integration of CD39 and traditional biomarkers could improve the prediction of responsiveness to PD-L1 blockade and platinum-based chemotherapy.

Methods
We retrospectively enrolled a total of 760 patients from IMvigor210 trial, TCGA database and Zhongshan Hospital in this study. We constructed the CPT scoring system based on CD39, PD-L1 and tumour mutation burden (TMB) and validated its efficacy in predicting therapeutic responsiveness in MIBC patients. Kaplan–Meier survival and Cox regression analyses were applied to assess clinical outcomes of patients.

Results
The CPT scoring system could predict the response to PD-L1 blockade and platinum-based chemotherapy. The CPT score was positively correlated with APOBEC mutational signature and SNV neoantigens enrichment, antigen presentation, and TCR signalling. High CPT score also indicated the inflamed immune phenotype and basal/squamous molecular subtype.

Conclusions
CD39 expression is closely correlated with the immunogenic contexture of MIBC. Integrating CD39 with PD-L1 and TMB could stratify the sensitivity of patients with MIBC to PD-L1 blockade and platinum-based chemotherapy.