bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thresholds between modulational stability, rogue waves and soliton regimes in saturable nonlinear media
Authors: Dias Wandearley , Buarque Anderson , Passos Frederico , Morais Denilson , Bezerra Luciano 
Published: September 2022

Abstract
We study a third-order nonlinear Schr ö dinger equation for a saturable nonlinear media, which can represent either optical pulse propagation in 1D nonlinear waveguide arrays or electron dynamics in one-dimensional lattices. Here, we describe how stable uniform solutions can evolve into regimes in which they are localized. We analyze the existence conditions for such dynamical regimes, as well as the intermediate (breather and chaotic-like solutions). Since regimes are significantly changed by the saturable parameter, we show phase diagrams with critical nonlinear strengths separating such regimes. Numerical data and analytical approach show the nonlinear strength above which uniform solutions become breather solutions increasing with the saturation parameter. We also reveal chaotic-like solutions exhibiting clear signatures of emerging rogue waves, such as peaks showing long-tailed statistics. The thresholds of this regime are increased by the saturable nonlinearity. On the other hand, the regime of localized solutions, which are well-described by bright soliton-like structures, becomes less accessible with increase of saturation.
Software components selection process: comparative study
Authors: Yahlali Mebarka 
Published: September 2022

Abstract
Component-Based Software Engineering (CBSE) paradigm aims to develop software by assembling and deploying reusable units, called software components. This approach tries to improve the flexibility, re-usability and maintainability of applications, and helps develop complex and distributed applications deployed on a wide range of platforms, by plugging commercial off-the-shelf (COTS) components, rather than building them from scratch. In this context, the selection step is very important. It consists of searching and selecting appropriate software components from a set of candidate components in order to satisfy the developer-specific requirements. In the selection process, both functional and non-functional requirements are generally considered. Several component selection processes have been proposed, with the aim of finding and selecting an appropriate software component from a set of candidate components to satisfy the developer's specific requirements
Benefits of Ketogenic Diet Beyond Epilepsy Control: Promising Enhancement in Adaptive Behavior
Authors: El-Rashidy Omnia , Nassar May , Shokair Wafaa , El-Gendy Yasmin 
Published: September 2022

Abstract
Background
The Ketogenic Diet (KD) is gaining attention as a management line in childhood drug resistant epilepsy (DRE). The objective of this study was to highlight KD benefits for Ain Shams University (ASU) Children’s Hospital patients.
Methods
This cross-sectional study included all patients at the Ketoclinic of ASU Children’s Hospital since its start. Anthropometric measurements and laboratory data were assessed. To evaluate KD efficacy, Chalfont severity score and daily frequency of epileptic attacks were recorded. Vineland test was used to demonstrate the adaptive behavior of a selected group of patients.
Results
The record of the Ketoclinic included 143 patients. Weight and height/length assessment showed significant increase with significant decrease in the severity of seizures and its frequency after KD. There were no significant changes in the lipid profile of the patients. Vineland test showed significant improvement in the adaptive behavior in 65%.
Conclusions
The Ketoclinic data proves that KD is a tolerable, safe, and effective line of therapy for DRE in children without significant negative impact on their anthropometric measurements or lipid profile. furthermore, the enhancement in adaptive behavior is a promising finding, thus it is prudent to recommend wider scale studies for longer duration to demonstrate additional cognitive benefits.
Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase
Authors: Yamakawa Kohei , Koyanagi-Aoi Michiyo , Machinaga Akihito , Kakiuchi Nobuyuki , Hirano Tomonori , Kodama Yuzo , Aoi Takashi 
Published: September 2022

Abstract
Background
Ours and several studies have reported that, in some cancers, including pancreatic ductal adenocarcinoma (PDAC), the expression of squamous lineage markers, such as esophagus-tissue specific genes, correlated with a poor prognosis. However, the mechanism by which the acquisition of squamous lineage phenotypes leads to a poor prognosis remains unclear. We previously reported that retinoic acid signaling via retinoic acid receptor γ (RARγ signaling) determines the differentiation lineage into the esophageal squamous epithelium. These findings hypothesized that the activation of RARγ signaling contributed to acquiring squamous lineage phenotypes and malignant behavior in PDAC.
Methods
This study utilized public databases and immunostaining of surgical specimens to examine RARγ expression in PDAC. We evaluated the function of RARγ signaling by inhibitors and siRNA knockdown using PDAC cell line and patient-derived PDAC organoids. The mechanism of the tumor-suppressive effects by blockage of RARγ signaling was determined by RNA-sequencing and Western blotting.
Results
RARγ expression increased via transformation from normal pancreatic duct to pancreatic intraepithelial neoplasia (PanIN) and PDAC, and its expression correlated with a poor patient prognosis. In PDAC cell lines, blockage of RARγ signaling suppressed cell proliferation by inducing the cell cycle arrest in the G1 phase without causing apoptosis. We demonstrated that blockage of RARγ signaling upregulated p21 and p27 and downregulated many cell cycle genes, including cyclin-dependent kinase 2 (CDK2), CDK4 and CDK6. Furthermore, using patient-derived PDAC organoids, we confirmed the tumor-suppressive effect of RARγ inhibition and indicated the synergistic effects of RARγ inhibition with gemcitabine.
Conclusions
This study clarified the function of RARγ signaling in PDAC progression and demonstrated the tumor-suppressive effect of selective blockage of RARγ signaling against PDAC. These results suggested that RARγ signaling might be a new therapeutic target for PDAC.
Medical Data Classification using Swarm Intelligence Technique
Authors: Tarle Balasaheb 
Published: September 2022

Abstract
In recent years, the clinical decision support system (DSS) has emerged as an important area in medical sciences to assist clinicians in medical diagnosis. Health records classification is based on learning from various health datasets to improve the better quality of DSS in health care. The main objective of this investigation is to establish a system for the successful classification of health data. OLPP orthogonal local preservation projection has been used to obtain promising outcomes in the classification of medical data. This is a high-dimensional data input package. A feature-reduction tool is then used to reduce the functionality space without compromising the calculation accuracy. The Artificial Neural Network shall be used as a classifier. We used an optimization algorithm to boost efficiency. The "artificial bee colony algorithm" is a bio-based optimization algorithm used by a neural network. The strategy for optimizing the NN artificial bee colony's weight during the learning process improves the performance of classification. Our proposed solution findings have shown that, in comparison to other types, our optimal classifier findings are better. The medical datasets used to represent the average improvement in the proposed system classification quality with the current form is around 15%.
Oxidative Stress-Related LncRNAs Serve as a Biomarker of Prognosis for Pancreatic Cancer
Authors: Huang Hao , Wei Yaqing , Yao Hao , Chen Ming , Sun Jinjin 
Published: September 2022

Abstract
Background: Long non-coding RNAs (lncRNAs) may play a role in oxidative stress by altering the tumor microenvironment, thereby affecting pancreatic cancer progression. There is currently limited information on oxidative stress-related lncRNAs as novel prognostic markers of pancreatic cancer.
Materials and Methods: Gene expression and clinical data of patients with pancreatic cancer were downloaded from The Cancer Genome Atlas (TCGA-PAAD) and the International Cancer Genome Consortium (ICGC-PACA) database. A weighted gene co-expression network analysis (WGCNA) was constructed to identify genes that were differentially expressed between normal and tumor samples. Based on the TCGA-PAAD cohort, a prediction model was established using lasso regression and Cox regression. The TCGA-PAAD and ICGC-PACA cohorts were used for internal and external validation, respectively. Furthermore, a nomogram based on clinical characteristics was used to predict mortality of patients. Differences in mutational status and tumor-infiltrating immune cells between risk subgroups were also explored and model-based lncRNAs were analyzed for potential immune-related therapeutic drugs.
Results: A prediction model for 6-lncRNA was established using lasso regression and Cox regression. Kaplan–Meier survival curves and receiver operating characteristic (ROC) curves indicated that patients with lower risk scores had a better prognosis. Combined with Cox regression analysis of clinical features, risk score was an independent factor predicting overall survival of patients with pancreatic cancer in both the TCGA-PAAD and ICGC-PACA cohorts. Mutation status and immune-related analysis indicated that the high-risk group had a significantly higher gene mutation rate and a higher possibility of immune escape, respectively. Furthermore, the model genes showed a strong correlation with immune-related therapeutic drugs.
Conclusion: Based on oxidative stress-related lncRNAs, this study demonstrated that using WGCNA to identify prognosis-related genes and combining Cox and lasso regression analysis facilitated the establishment of a new signature that may more accurately and effectively predict the prognosis of patients with pancreatic cancer.
Digestibility of protein and iron bioavailability from enriched sprouts
Authors: Zielińska-Dawidziak Magdalena , Białas Wojciech , Piasecka-Kwiatkowska Dorota , Staniek Halina , Niedzielski Przemysław 
Published: September 2022

Abstract
Plant ferritin is suggested as a good source of iron for human. Usually present in trace amounts, it was induced in legumes seeds by their sprouting in FeSO4 solution. Fortified sprouts were digested in the in vitro model of the human gastrointestinal tract. ~49% of lupine and ~ 45% of soy proteins were extracted into gastric fluid and next ~ 12% and only ~ 1% into intestine fluid from lupine and soybean, respectively. Gastric digestion released mainly ferrous iron (~ 85% from lupine and ~ 95% in soybean sprouts). Complexed iron constituted ~ 43% of total iron in intestine after lupine digestion and ~ 55% after soybean digestion. Intestine digestion doubled the total iron released from lupine sprouts (from ~ 21% up to 38%), while in soybean it increase from ~ 16% up to ~ 23%. Ferritin presence was confirmed by the specific antibodies in digestive fluids, but it is only partially extracted from sprouts during in vitro digestion.
Cervical lordosis ratio is an effective parameter for selecting the posterior approach of multisegmental cervical spondylotic myelopathy
Authors: Ma Sheng , Miao Jia Hang , Yu Hui Lin , Qu Zhe , Pan Bin , Feng Hu 
Published: September 2022

Abstract
Purpose: The cervical lordosis ratio (CLR), an index of cervical hyperextension and hyperflexion, was used to validate the posterior approach selection strategy in patients with multisegmental cervical spondylotic myelopathy. (MCSM).
Methods:A retrospective review of 141 patients who had undergone posterior cervical surgery for MCSM in our hospital between December 2015 and March 2020 was conducted, with 63 patients receiving laminectomy and fusion (LCF group) and 78 patients receiving laminoplasty (LP group).The demographic characteristics of the two groups (gender, age, BMI, and follow-up time) were compared. C2-7 Cobb angle (CL), C2-7 range of motion (C2-7ROM), flexion Cobb angle (flexCL), extension Cobb angle (extCL), flexion range of motion (flexROM), and extension range of motion (extROM) were compared between the two groups (extROM). The clinical effect indices of the two groups, including the JOA and VAS scores, were compared. The C2-7cobb angle difference before and after operation (ΔCL), namely postoperative C2-7 Cobb angle (postCL) - preoperative C2-7 Cobb angle (preCL), was used to assess cervical lordosis alignment change . Calculate the cervical lordosis ratio (CLR) using 100% flexROM/C2-7ROM.The function of the CLR ratio in predicting postoperative severe cervical lordosis loss (CL -10) was evaluated using ROC curve analysis. All patients were separated into a low ratio group (L-CLR) and a high ratio group(H-CLR) based on the critical value of the CLR ratio (68.5%). The cervical lordosis alignment index and clinical impact index between the two operation groups were once more analyzed in these two ratio groups. The differences of various indicators between the two operating groups and the corresponding indicators between different ratio groups were assessed and compared using an independent sample t-test.
Results: Cervical lordosis alignment index decreased significantly after LCF and LP (p=0.039,p=0.002), and cervical lordosis alignment change（ΔCL) in LP group was greater than that of LCF group (p=0.043), and the difference between the two groups was statistically significant (p=0.043). According to ROC curve analysis, the CLR ratio can predict severe cervical lordosis alignment change (ΔCL≥-10) with great precision (AUC=0.792). There was no significant difference in cervical lordosis alignment change (CL) between the LCF and LP groups in the L-CLR group (p=0.141). The CL of the LP group in the H-CLR group was greater than that of the LCF group (P(ΔCL≥ -10), which had a higher probability of postoperative severe cervical lordosis alignment change (42.6%,28.5%).
Conclusions: The cervical lordosis ratio could be used as a decision-making index for the choice of posterior surgery approach for multisegmental cervical spondylotic myelopathy. Laminoplasty could be considered in the low ratio group, while laminectomy and fusion could be considered in the high ratio group.
Self-gripping mesh in laparoscopic obturator hernia repair: clinical experience in a single institution
Authors: Sugiyama Tomohiro , Takeuchi Yuji , Kinoshita Osamu , Mori Yoshihiro , Ishikawa Akira , Kominami Hiroaki , Urano Naomi , Higuchi Ichiro , Hasuike Yasunori 
Published: September 2022

Abstract
Purpose: We propose a treatment strategy for obturator hernia repair using a self-fixating mesh. An obturator hernia is a relatively rare type of abdominal hernia with a high mortality rate, with surgery being the only treatment option. Various approaches to repairing obturator hernia using meshes and tackers have been proposed. Nonetheless, postoperative complications such as chronic inguinal pain and hemorrhage have been reported with tacker-fixated mesh approaches.
Although the self-adhesive property of a self-fixating mesh enables tacker-less hernia repair, it is rarely used in inguinal hernia repair. Tacker-less repair reduces the likelihood of chronic pain development; however, the difficulty in handling the mesh in the abdominal cavity must be overcome.
Methods: We have been using a self-fixating mesh (PG mesh; ProGrip™ laparoscopic self-fixating mesh) for obturator hernia repair since April 2020. In two cases preceding the introduction of the PG mesh for obturator hernia repair, we experienced difficulty attaching the PG mesh; nevertheless, we successfully performed obturator hernia repair by simplifying the method, using three steps, to attach the PG mesh.
Results: Between April 2020 and September 2021, we encountered seven cases of obturator hernia. Of these cases, five were repaired using the PG mesh. Postoperatively, one patient had a small subcutaneous hematoma with no postoperative complications, including chronic pain and hemorrhage. The postoperative recovery time was not prolonged, and there was no recurrence of symptoms during the observation period.
Conclusion: PG mesh appears to be suitable for obturator hernia repair.
Exposure of dogs and cats to Borrelia miyamotoi infected Ixodes ricinus ticks in urban areas of the city of Poznań, west-central Poland
Authors: Liberska Justyna , Michalik Jerzy , Dabert Mirosława 
Published: September 2022

Abstract

Background
Borrelia miyamotoi is an emerging human pathogen causing relapsing fever-like disease termed B. miyamotoi disease. The bacterium belongs to relapsing fever borreliae and similarly as spirochete species from the group of Borrelia burgdorferi sensu lato, is transmitted only by hard-bodied ticks within the Ixodes ricinuscomplex. Borrelia miyamotoi has not been so far shown to cause illness in dogs or cats, and is poorly documented in veterinary medicine. The aim of our study was to determine the B. miyamotoi infection prevalence in (i) host-seeking and (ii) engorged Ixodes sp. ticks collected from dogs and cats during their inspection in veterinary clinics of the city of Poznań, west-central Poland.
Methods
Host-seeking ticks were sampled in dog walking areas localized in urban forested recreational sites of the city. We screened 1059 host-seeking and 837 engorged I. ricinus ticks removed out of 680 tick infested animals (567 dogs and 113 cats). Moreover, 31 I. hexagonus ticks (one larva, 13 nymphs and 17 females) were collected from three cats and one larva and one nympf from two dogs and one dog was infested with a single Dermacentor reticulatus female.
Borrelia species were identified by amplification and sequencing of the V4 hypervariable region of the 16S rRNA gene and the flaB gene fragments.
Results
DNA of B. miyamotoi was detected in 22 (2.1%) of the host-seeking ticks, in all developmental tick stages, and in all study areas. A similar infection prevalence (1.8%) was identified in the engorged I. ricinus ticks. Out of the infested animals, 2.2% were exposed to B. miyamotoi positive ticks. Out of the I. hexagonus ticks, three (9.1%) one female and two nymph , yielded DNA of B. miyamotoi. A single Dermacentor reticulatusfemale collected from a dog tested PCR-negative for the bacterium.
Conclusions
Our results demonstrate that the bacterium is well-established and broadly present in tick populations from different urban ecosystems of the city of Poznań. The lack of difference in mean infection prevalence between animal-derived and host-seeking I. ricinus ticks, suggests that systematic surveillance of pets, may be useful to evaluate the risk of acquiring Borrelia miyamotoi disease in urban areas. Additional studies are needed to further elucidate the role of domestic and wild carnivores in the epidemiology of B. miyamotoi which remains unknown.
Stable organic carbon formation accelerated by manganese oxide mineral reduction and the implications for the global carbon cycle
Authors: Purvis Graham , Johnson Karen L. , Peacock Caroline , Wegorzewski Anna , Sano Naoko , Sheriff Jake , Cumpson Peter , Lopez-Capel Elisa 
Published: September 2022

Abstract
Marine and terrestrial sediments stabilise organic carbon (OC) against microbial respiration, influencing the climate by slowing the release of CO2 into the atmosphere. Redox-active element-bearing minerals, such as the manganese oxide mineral birnessite (δMnO2) play an important role in OC stabilisation. However, the mechanism for birnessite-OC stabilisation is unclear, limiting further understanding of the role of birnessite in the carbon cycle. We hypothesise that bond formation is promoted on δMnO2 surfaces, ultimately producing a complex assembly of stabilised OC. We test our hypothesis by investigating δMnO2 samples spanning < 1 year to 2.5 billion years old, using X-ray photoelectron spectroscopy and thermogravimetric analysis to synergistically observe OC thermal decomposition. We propose that thermally stable OC is generated during δMnO2 reduction. We speculate that thermally stable OC is unsuitable for rapid microbial respiration and is therefore chronologically stable. We conclude that the OC stabilisation described here could be an important but hitherto unrecognised process that removes OC from the readily exchangeable OC pool, thereby helping to modulate the climate.
The Diagnostic Accuracy of 332 Incisional Biopsies in Patients with Malignant Tumors in the Musculoskeletal System
Authors: Dirks Michael , Ewerbeck Nicolas Konstantin , Ballhause Tobias Malte , Weiß Sebastian , Luebke Andreas , Schlickewei Carsten , Frosch Karl-Heinz , Priemel Matthias 
Published: September 2022

Abstract
It is known that specimen collection followed by histopathological workup is the core of evidence-based medical therapy of musculoskeletal tumors. There exist many controversies about how a biopsy should be performed. While some centers recommend minimal invasive biopsy procedures, mostly the core needle biopsy (CNB), others prefer the incisional biopsy. This study aimed to determine the accuracy of incisional biopsy for malignant tumors in the musculoskeletal system. Moreover, advantages and disadvantages to other biopsy methods are discussed. This retrospective, single-center study about 844 incisional biopsies (benign and malignant) analysis the diagnostic accuracy of 332 malignant tumors, concerning the final histopathological result. In addition, surgical complications are analyzed to find the best way to plan and treat patients timely and correct. Secondary endpoints are the patients age, the pure operation time, as well as the type of tumor, and the subsequent therapy. In summary, incisional biopsy corresponded a sensitivity of 100% for malignancy in 844 incisional biopsies and a specificity of 97.6% in 332 malignant tumors, but it features greater operative expense (incision/suture 23.5 min) and the risk of general anesthesia. The method of biopsy should be tailored to the individual patient and the experience of the center performing the procedure.
The Prediction for moisture content at the outlet of tobacco blending and flavoring with non-equidistant grey model GM(1,1)
Authors: LI Zijuan , Chen Jiaojiao , Sun Shuo , Gao Yang , Feng Zixian , Zhao Liyuan , Ma Yanling , Lv Xuan 
Published: September 2022

Abstract
In order to solve the problem of no moisture monitoring point and feedback lag after the cut tobacco blending and flavoring, a grey system theory was applied to propose a moisture prediction method for the tobacco blending and flavoring outlet. Using the historical data of Diamond (yinghong) cut tobacco blending and flavoring outlet moisture in Zhangjiakou Cigarette Factory as gray numbers, a non-equidistant gray GM (1, 1) model was established, and the residual error was corrected by the support vector regression machine, t-3 , t-2, t-1 corresponding residuals are used as input data, and the residuals at time t are used as output data to update the non-equidistant gray GM (1, 1) model. The model was used to predict the moisture content of tobacco blending and flavoring outlet and the accuracy test. The results showed that the posterior difference test ratio was C=0.348<0.35, the average relative error was less than 0.1, P=1>0.95, and the model was more accurate. Use information technology to establish a data prediction module, form a tobacco blending and flavoring outlet moisture prediction system, and feed back the adjustment of the drying outlet moisture control. After the system is applied, the relative error of tobacco blending and flavoring outlet moisture prediction is <0.3%.