bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune thrombocytopenia and risk of stroke: Evidence from a nationwide population-based cohort study
Authors: Chen Hsin-Yu , Lee Wei-Kai , Chang Renin , Hung Yao-Min , Hsu Chung Y , Shih Ying-Hsiu , Chen Jin-Shuen 
Published: September 2022

Background: Research investigating differences in the overall stroke risk between individuals with and without immune thrombocytopenia (ITP) is lacking. Methods: This real-world study used the National Health Insurance Research Database (NHIRD). Risk of stroke was compared between 13,085 individuals with ITP enrolled between 1 January 2000 and 31 December 2015 and a control cohort of 52,340 individuals without ITP (1:4 ratio propensity score–matched by age, sex, index year, relevant comorbidities, and medications). Sub-distribution hazards models were used to estimate adjusted sub-distribution hazard ratio (SHR) and 95% confidence intervals (CIs), with the non-ITP group as the control group. Results: Of the 65,425 participants, 13,085 had ITP, 63.3% were women, and the mean age was 52.59 years. The risk of both ischemic and hemorrhagic stroke was 1.14 times (adjusted SHR 1.14, 95% CI, 1.07–1.22) and 1.93 times (adjusted SHR 1.93, 95% CI, 1.70–2.20) higher in the ITP group than in controls. Patients with ITP in the 20- to 29-year subgroup had a higher risk of new-onset stroke (adjusted SHR, 4.06 (95% CI, 2.72–6.07), p value for interaction <0.01) than those aged 20–29 years without ITP. Individuals with severe ITP with splenectomy had a 1.79 times higher overall stroke risk than those without. Conclusions: ITP is associated with increased risk of both ischemic and hemorrhagic stroke.
Oral surgery: Considerations for the younger patient
Authors: Bryant Cathy 
Published: September 2022

The need for oral surgery will, for many younger patients, precipitate their first significant interaction with healthcare professionals; this will inevitably impact on the planning and delivery of their treatment. This paper will describe the range of oral surgical procedures which are most commonly performed on younger patients. It will explore the indications for treatment, the techniques used to promote successful treatment outcomes, and the role of general dental practitioners in the management of younger patients undergoing oral surgery. Consideration will be given to the unique challenges encountered when undertaking surgical procedures in younger patients with a dentition which is still developing.
Novel insights into the association between seasonal variations, blood pressure, and blood pressure variability in patients with new-onset essential hypertension
Authors: Tang Long , Zhang Jingshui , Xu Yanan , Xu Tingting , Yang Yi , Wang Jun 
Published: September 2022

AbstractBackgroundBlood pressure (BP) exhibits seasonal variations, with peaks reported in winter. However, the association between seasonal variations and blood pressure variability in patients with new-onset essential hypertension is not fully understood. This study evaluated the potential association of seasonal variations with new-onset essential hypertension.MethodsThis retrospective observational study recruited a total of 440 consecutive patients with new-onset essential hypertension who underwent 24-h ambulatory electrocardiograph (ECG) and BP measurement at our department between January 2019 and December 2019. Demographic and baseline clinical data including BP variability, heart rate variability, and blood tests were retrieved. Multivariate linear regression analysis was performed to identify factors independently associated with mean BP and BP variability.ResultsAmong the 440 patients recruited, 93 cases were admitted in spring, 72 in summer, 151 in autumn, and 124 in winter. Univariate analysis revealed that systolic BP (SBP), diastolic BP (DBP), high-sensitivity C-reactive protein, SBP drop rate, DBP drop rate, 24-h standard deviation of SBP, 24-h standard deviation of DBP, 24-h SBP coefficient of variation, and 24-h DBP coefficient of variation were associated with patients admitted in winter (P < 0.05 for all). Multivariate linear regression analysis showed that winter was the influencing factor of 24-h standard deviation of SBP (B = 1.851,t = 3.719,P < 0.001), 24-h standard deviation of DBP (B = 1.176,t = 2.917,P = 0.004), 24-h SBP coefficient of variation (B = 0.015,t = 3.670,P < 0.001), and 24-h DBP coefficient of variation (B = 0.016,t = 2.849,P = 0.005) in hypertensive patients.ConclusionsSeasonal variations are closely associated with BP variability in patients with new-onset essential hypertension. Our study provides insight into the underlying pathogenesis of new-onset essential hypertension.
Adverse obstetric outcome and its associated factors in public hospitals of North Ethiopia: does parity make a difference?
Authors: Tadese Mesfin , Tessema Saba Desta , Taye Birhan Tsegaw , Mulu Getaneh Baye 
Published: September 2022

Abstract
Background
Direct obstetric causes account for nearly 75% of all maternal deaths. Controversy prevails in the effect of grand multiparity on adverse obstetric outcomes. This study thus aimed to determine and compare the obstetric outcomes in low multiparous (LM) and grand multiparous (GM) women in Public Hospitals of North Ethiopia.

Method
An institution-based comparative cross-sectional study was done among 540 (180 GM and 360 LM) participants from January 1 to March 30, 2021. The data was collected through face-to-face interviews and a review of clinical records and birth registries. Epi-Data version 4.6 was used for data entry and analysis was performed using SPSS version 25.0 statistical software. A p-value of ≤ 0.05 (2-tailed) was used to consider the significance of statistical tests.

Result
The prevalence of adverse obstetric outcomes was 32.6% (95% CI: 28.7–36.5). Antepartum hemorrhage, anemia, and postpartum hemorrhage were higher in grand multiparous women. Whereas, prolonged labor, induction/augmentation, prelabor rupture of membrane, episiotomy, and post-term pregnancy was higher in low multiparous women. Income (AOR (CI) = 3.15 (1.30–7.63), alcohol consumption (AOR (CI) = 3.15 (1.49–6.64), preterm delivery (AOR (CI) = 9.24 (2.28–27.3), cesarean delivery (AOR (CI) = 13.6 (6.18–30.1), and low birth weight (AOR (CI) = 3.46 (1.33–9.03) significant predictors of adverse obstetric outcomes. However, parity did not show a statistically significant difference in obstetric outcomes.

Conclusion
In the study area, obstetric complications were high compared to a systematic review and meta-analysis study done in the country (26.88%). Socio-economic status, alcohol consumption, gestational age at delivery, mode of delivery, and birth weight were significant associates of the obstetric outcome. There was no statistically significant difference in obstetric outcomes between GM and LM women. Socio-economic development, avoiding alcohol consumption, early identification and treatment of complications, and adequate nutrition and weight gain during pregnancy are needed regardless of parity.
The relationship model among parent–child relationship, coping responses and behavioral problems in children with attention deficit hyperactivity disorder
Authors: Taghizade Soulmaz , Mahmoodi Zohreh , Zandifar Atefeh , Qorbani Mostafa , Mohamadi Farima , Mehrafzoun Niloufar 
Published: September 2022

Abstract
Background
Attention Deficit Hyperactivity Disorder (ADHD) constitutes a prevalent behavioral problem. The present study examined the parent–child relationship model and investigated strategies to cope with behavioral problems in children with ADHD.

Methods
This descriptive study selected 300 children with ADHD using convenience sampling. The data collected using the child behavior checklist, the parent–child relationship scale (PCRS), the Billings and Moos Coping Checklist, the socioeconomic status questionnaire, the general health questionnaire-28 (GHQ-28) and a demographic checklist were analyzed in SPSS-25 and LISREL 8.8.

Results
According to the results of the path analysis on the relationship model among parent–child relationship domains, coping responses and children's behavioral problems, parent–child dependency domain (B = 0.22) in the direct path, disease duration (B = 0.085) in the indirect path, and conflicts in the domain of parent–child relationship (B = 0.366) in both direct and indirect paths had the most positive causal effect on behavioral problems. Furthermore, intimacy in the said domain (B = -0.42) had the most negative causal effect in both direct and indirect paths. The extent to which parents used coping responses via the direct path had a positive causal effect on behavioral problems (B = 0.12).
Based on the path analysis test findings in the relationship model among positive parent–child relationship, coping responses and children's behavioral problems, the positive parent–child relationship score had the most negative causal effect via the direct path (B = -0.56). Conversely, the child's age had the highest positive causal effect via the indirect path (B = 0.1) on behavioral problems in children.

Conclusion
Based on findings, there is a causal and significant relationship between the parent–child relationship and the extent to which coping responses are used. It is recommended that training programs be developed to strengthen communication skills, coping responses and problem-solving techniques in parents.
Statistical modeling of health space based on metabolic stress and oxidative stress scores
Authors: Park Cheolgyun , Kim Youjin , Lee Chanhee , Kim Ji Yeon , Kwon Oran , Park Taesung 
Published: September 2022

AbstractBackgroundHealth space (HS) is a statistical way of visualizing individual’s health status in multi-dimensional space. In this study, we propose a novel HS in two-dimensional space based on scores of metabolic stress and of oxidative stress.MethodsThese scores were derived from three statistical models: logistic regression model, logistic mixed effect model, and proportional odds model. HSs were developed using Korea National Health And Nutrition Examination Survey data with 32,140 samples. To evaluate and compare the performance of the HSs, we also developed the Health Space Index (HSI) which is a quantitative performance measure based on the approximate 95% confidence ellipses of HS.ResultsThrough simulation studies, we confirmed that HS from the proportional odds model showed highest power in discriminating health status of individual (subject). Further validation studies were conducted using two independent cohort datasets: a health examination dataset from Ewha-Boramae cohort with 862 samples and a population-based cohort from the Korea association resource project with 3,199 samples.ConclusionsThese validation studies using two independent datasets successfully demonstrated the usefulness of the proposed HS.
Complete remission of alpha-fetoprotein-producing gastric cancer by combined tislelizumab-apatinib treatment of a patient with proficient mismatch repair: a case report
Authors: Xiang Jinyu , Gong Wenjing , Wang CongCong , Sun Ping , Liu Aina 
Published: September 2022

Abstract
Background
Alpha‑fetoprotein-producing gastric cancer (AFPGC) is a rare type of gastric cancer with a high rate of metastasis and poor prognosis. Despite substantial progress in the treatment of many solid tumors, there are no reports of the safety and effectiveness of immune checkpoint inhibitors in combination with antiangiogenesis agents for AFPGC patients who have proficient mismatch repair.

Case presentation
We describe a 69-year-old man who was diagnosed with metastatic AFPGC. After progression to chemotherapy resistance, tislelizumab combined with apatinib was administered, although the patient’s gastroscopic pathology showed proficient mismatch repair. After three cycles of therapy, partial remission (reduced by 56%) was obtained, and the quality of life improved significantly. Surprisingly, after more than 1 year of continuous application of the combination treatment regimen, both the primary and metastatic tumors in this patient eventually disappeared, which obtained complete remission without surgery. The patient has had a progression-free survival of more than 24 months and is still continuing to benefit.

Conclusions
This case is the first example of effective treatment of AFPGC with tislelizumab combined with apatinib. The outcomes of this case suggest a highly effective and tolerable therapeutic strategy for microsatellite-stabilized AFPGC.
Synovial fluid and radiographic evaluation of joints from dogs with visceral leishmaniasis
Authors: Silva Alexandre R. S. , Gomes Ana A. D. , Aquino Monally C. C. , Almeida Breno F. M. , Lima Valéria M. F. , Ciarlini Paulo C. , Pinoti Luciana D. R. , Marcondes Mary , Vieira Rafael F. C. 
Published: September 2022

Abstract
Background
Polyarthritis has been associated with canine visceral leishmaniasis (CanVL), and co-infection with Ehrlichia canis is common and may alter clinical manifestations.

Methods
A total of 89 dogs presenting CanVL were subdivided into two groups: (1) G1, consisting of 46 dogs seronegative to Ehrlichia spp., and (ii) G2, consisting of 43 dogs seropositive to Ehrlichia spp. Eight joints (carpal, tarsal, stifles and elbows) from each dog were evaluated by radiography and synovial fluid (SF) cytologic analysis.

Results
Overall, 74 of the 89 (83.1%) dogs presented joint abnormalities suggestive of osteoarthritis by radiography (G1: 40/46 [86.9%]; G2: 34/43 [79.0%]), with no statistically significant between-group difference. All dogs with abnormal joint X-ray images presented radiographic lesions bilaterally, independent of the characteristics of the lesion. Soft tissue swelling around the joint and joint space narrowing were more commonly observed in G1 than in G2 dogs. There was no significant between-group difference in terms of other radiographic abnormalities suggestive of osteoarthritis (evident trabecular pattern, subchondral bone sclerosis, osteolysis, osteolytic–proliferative lesions or bone proliferation). SF from 174/315 (55.2%) and 152/307 (49.5%) joints from G1 and G2 dogs, respectively, presented an inflammatory infiltrate, but there was no significant association between the presence of inflammatory infiltrate and group. There was also no statistical difference between groups in either of the evaluated joints in terms of the percentage of neutrophils or mononuclear cells. Leishmania spp. amastigotes were found in 69/315 (21.9%) joints from G1 dogs and in 100/307 (32.5%) joints from G2 dogs (Fisherʼs exact test, P = 0.002, odds ratio = 0.5, 95% confidence interval = 0.4–0.8). The neutrophilic infiltrate was significantly higher in joints with amastigote forms in both G1 (Mann–Whitney U-test, U(18) = 817, Z = -3.76, P = 0.0001) and G2 dogs (Mann–Whitney U-test, U(18) = 6543, Z = − 5.06, P < 0.0001).

Conclusions
A high prevalence of arthritis in dogs with CanVL was found, and all dogs presented involvement in multiple joints. Although no difference was observed between groups in terms of the number of dogs with polyarthritis and the presence of an inflammatory infiltrate in SF, Leishmania spp. amastigotes were found more frequently in joints from G2 dogs. Further studies evaluating SF in dogs co-infected with L. infantum and E. canis should be performed to evaluate this finding.

Graphical Abstract
Global error bounds of the extended vertical linear complementarity problems for Dashnic–Zusmanovich matrices and Dashnic–Zusmanovich-B matrices
Authors: Zhao Yingxia , Sun Deshu 
Published: September 2022

AbstractGlobal error bounds of the extended vertical linear complementarity problems for Dashnic–Zusmanovich (DZ) matrices and Dashnic–Zusmanovich-B (DZ-B) matrices are presented, respectively. The obtained error bounds are sharper than those of Zhang et al. (Comput. Optim. Appl. 42(3):335–352, 2009) in some cases. Some numerical examples are given to illustrate the obtained results.
Optimal industrial flexibility scheduling based on generic data format
Authors: Bahmani Ramin , Stiphoudt Christine van , Menci Sergio Potenciano , SchÖpf Michael , Fridgen Gilbert 
Published: September 2022

AbstractThe energy transition into a modern power system requires energy flexibility. Demand Response (DR) is one promising option for providing this flexibility. With the highest share of final energy consumption, the industry has the potential to offer DR and contribute to the energy transition by adjusting its energy demand. This paper proposes a mathematical optimization model that uses a generic data model for flexibility description. The optimization model supports industrial companies to select when (i.e., at which time), where (i.e., in which market), and how (i.e., the schedule) they should market their flexibility potential to optimize profit. We evaluate the optimization model under several synthetic use cases developed upon the learnings over several workshops and bilateral discussions with industrial partners from the paper and aluminum industry. The results of the optimization model evaluation suggest the model can fulfill its purpose under different use cases even with complex use cases such as various loads and storages. However, the optimization model computation time grows as the complexity of use cases grows.
How unique is weekly smart meter data?
Authors: Radovanovic Dejan , Unterweger Andreas , Eibl Günther , Engel Dominik , Reichl Johannes 
Published: September 2022

AbstractIn many countries, energy consumption data is collected through smart meters in 15-min intervals. Prior work has shown that 1 year’s worth of this data is sufficient to extract sensitive information about households. In this short paper, we break down energy consumption data from a novel dataset into 1-week snippets. Using off-the-shelf algorithms, we assess whether it is possible to clearly identify (i.e., fingerprint) an individual household only by its energy consumption from a 1-week period. More generally, we ask whether an attacker can distinguish one household from a group of others by its energy consumption from only one week’s worth of data. We find that a small number of households exist for which the weekly consumption is so unique that it can be distinguished almost always amidst weekly data from dozens of other households. Furthermore, a large number of households can be distinguished with surprisingly high accuracy and an order of magnitude better than guessing. We discuss the potential impact of these findings on the privacy of smart meter datasets with respect to de-anonymization and re-identifiability.
On specification-based cyber-attack detection in smart grids
Authors: Sen Ömer , van der Velde Dennis , Lühman Maik , Sprünken Florian , Hacker Immanuel , Ulbig Andreas , Andres Michael , Henze Martin 
Published: September 2022

AbstractThe transformation of power grids into intelligent cyber-physical systems brings numerous benefits, but also significantly increases the surface for cyber-attacks, demanding appropriate countermeasures. However, the development, validation, and testing of data-driven countermeasures against cyber-attacks, such as machine learning-based detection approaches, lack important data from real-world cyber incidents. Unlike attack data from real-world cyber incidents, infrastructure knowledge and standards are accessible through expert and domain knowledge. Our proposed approach uses domain knowledge to define the behavior of a smart grid under non-attack conditions and detect attack patterns and anomalies. Using a graph-based specification formalism, we combine cross-domain knowledge that enables the generation of whitelisting rules not only for statically defined protocol fields but also for communication flows and technical operation boundaries. Finally, we evaluate our specification-based intrusion detection system against various attack scenarios and assess detection quality and performance. In particular, we investigate a data manipulation attack in a future-orientated use case of an IEC 60870-based SCADA system that controls distributed energy resources in the distribution grid. Our approach can detect severe data manipulation attacks with high accuracy in a timely and reliable manner.
Optical neuroimaging: advancing transcranial magnetic stimulation treatments of psychiatric disorders
Authors: Jiang Shixie , Carpenter Linda L. , Jiang Huabei 
Published: September 2022

AbstractTranscranial magnetic stimulation (TMS) has been established as an important and effective treatment for various psychiatric disorders. However, its effectiveness has likely been limited due to the dearth of neuronavigational tools for targeting purposes, unclear ideal stimulation parameters, and a lack of knowledge regarding the physiological response of the brain to TMS in each psychiatric condition. Modern optical imaging modalities, such as functional near-infrared spectroscopy and diffuse optical tomography, are promising tools for the study of TMS optimization and functional targeting in psychiatric disorders. They possess a unique combination of high spatial and temporal resolutions, portability, real-time capability, and relatively low costs. In this mini-review, we discuss the advent of optical imaging techniques and their innovative use in several psychiatric conditions including depression, panic disorder, phobias, and eating disorders. With further investment and research in the development of these optical imaging approaches, their potential will be paramount for the advancement of TMS treatment protocols in psychiatry.
Simulated virtual on-call training programme for improving non-specialised junior doctors' confidence in out-of-hours psychiatry: quantitative assessment
Authors: Blamey Helen , Harrison Charlotte H. , Roddick Alistair , Malhotra Tina , Saunders Kate E. A. 
Published: September 2022

Aims and methodTo investigate whether a psychiatry-specific virtual on-call training programme improved confidence of junior trainees in key areas of psychiatry practice. The programme comprised one 90 min lecture and a 2 h simulated on-call shift where participants were bleeped to complete a series of common on-call tasks, delivered via Microsoft Teams.ResultsThirty-eight trainees attended the lecture, with a significant improvement in confidence in performing seclusion reviews (P = 0.001), prescribing psychiatric medications for acute presentations (P < 0.001), working in section 136 suites (places of safety) (P = 0.001) and feeling prepared for psychiatric on-call shifts (P = 0.002). Respondents reported that a virtual on-call practical session would be useful for their training (median score of 7, interquartile range 5–7.75). Eighteen participants completed the virtual on-call session, with significant improvement in 9 out of the 10 tested domains (P < 0.001).Clinical implicationsThe programme can be conducted virtually, with low resource requirements. We believe it can improve trainee well-being, patient safety, the delivery of training and induction of rotating junior doctors during the COVID-19 pandemic and it supports the development and delivery of practical training in psychiatry.
Food hypersensitivity - classification, pathogenesis, diagnosis. What are food allergies?
Authors: Dąbrowski Jan , Gąbka Ilona , Dalmata Weronika , Dębek Karolina , Lipiec Marta 
Published: September 2022

Introduction: Food hypersensitivity is a pathological, increased and inadequate reaction of the body to a particular substance, the consumption of which can cause various types of body symptoms.
Purpose: The purpose of this study is to distinguish different types of hypersensitivity mechanisms, resulting in the introduction of appropriate diagnosis and treatment.
Results and conclusions: Food hypersensitivity is becoming an epidemic of the 21st century. This is due to many individual factors as well as environmental pollution. It is important to identify the type of mechanism involved in a given food hypersensitivity and to eliminate the causative factors, or incorporate appropriate treatment. Understanding this forms the basis of therapy.
Methods: Data for the article were retrieved using PubMed setting the time descriptors to 2014-2020.