bluuebunny/crossref_metadata_2025_split huggingface dataset:
Employment outcomes in family supporters of patients with early stage breast cancer and their association with patients’ health‐related quality of life and financial burden
Authors: Veenstra Christine M. , Braun Thomas M. , Abrahamse Paul H. , Wittmann Daniela , Hawley Sarah T. 
Published: February 2022

AbstractBackgroundLittle is known about how cancer impacts the employment status of patients’ family supporters, or about associations between patients’ health‐related quality of life, perceived financial burden, and supporters’ employment trajectory.MethodsWe surveyed patients with early stage breast cancer reported to the Georgia and Los Angeles SEER registries in 2014–15, and their spouse/partner or other family supporters. Patients and supporters were asked about employment impacts of the patient’s cancer, and descriptive analyses of supporters’ employment trajectories were generated. We measured patients’ health‐related quality of life (HRQoL) using the PROMIS scale for global health. We measured patients’ perceived financial burden attributed to cancer by asking them two questions regarding (i) their financial status since their breast cancer diagnosis and (ii) how much it was impacted by their breast cancer and treatment. Associations between patients’ HRQoL, perceived financial burden, and supporters’ employment status were assessed using linear mixed model regression analyses.ResultsIn total, 2502 patients (68% response rate) and 1203 supporters (70% response rate) responded; 1057 paired patient‐supporter dyads were included. Similar proportions of spouse/partner and other family supporters reported missed work and lost employment due to patients’ cancer. After adjustment, lower HRQoL and an increased odds of perceived financial burden among patients were associated with changes in other family supporters’ employment (both p < 0.05), but not with changes in spouses’/partners’ employment. Lower HRQoL was also associated with changes in patients’ own employment among patients with both types of supporters (both p < 0.001). An increased odds of perceived financial burden among patients was associated with changes in patients’ employment only in those supported by other family members (p < 0.001).ConclusionsBoth spouse/partner and other family supporters faced adverse employment outcomes due to patients’ cancer. This contributes to worse HRQoL and greater perception of financial burden among patients, especially those whose supporter is not a spouse/partner.
How do possessiveness, nongenerosity and envy in young female consumers convert into shopping addiction?
Authors: Jhamb Deepika , Mittal Amit 
Published: February 2022

AbstractThe present age is witnessing a rise in materialism and its sub‐traits such as possessiveness, nongenerosity and envy. Combined with a marked increase in habitual shopping, this trend has resulted in some degree of shopping addiction. There are scant studies on contribution of materialistic tendencies of consumers towards shopping addiction; therefore, this study aimed to examine the effect of the sub‐traits of materialism (possessiveness, nongenerosity and envy) on shopping addiction. The role of hedonic shopping motives and self‐efficacy as mediators was also investigated. Data for the study were derived by administering a structured questionnaire to 423 young female consumers from the northwest region of India. The structural equation modelling technique was used to empirically evaluate the proposed model. The results confirmed that the personality traits pertaining to materialism have a significant impact on hedonic shopping motives and self‐efficacy, potentially triggering shopping addiction in young female consumers. The findings offer fresh insights for academicians, researchers and market practitioners into the impact of the materialistic attitudes of young female consumers on their buying habits. This study is unique as it provides an unprecedented holistic view of factors predicting the materialistic behaviour of young female consumers in fast‐growing, emerging markets and its impact on their consumption behaviour.
Percutaneous mechanical thrombectomy in a real‐world pulmonary embolism population: Interim results of the FLASH registry
Authors: Toma Catalin , Bunte Matthew C. , Cho Kenneth H. , Jaber Wissam A. , Chambers Jeffrey , Stegman Brian , Gondi Sreedevi , Leung Daniel A. , Savin Michael , Khandhar Sameer , Kado Herman , Koenig Gerald , Weinberg Mitchell , Beasley Robert E. , Roberts Jon , Angel Wesley , Sarosi Michael G. , Qaqi Osama , Veerina Kalyan , Brown Michael A. , Pollak Jeffrey S. 
Published: February 2022

AbstractObjectivesThe FlowTriever All‐Comer Registry for Patient Safety and Hemodynamics (FLASH) is a prospective multi‐center registry evaluating the safety and effectiveness of percutaneous mechanical thrombectomy for treatment of pulmonary embolism (PE) in a real‐world patient population (NCT03761173). This interim analysis reports outcomes for the first 250 patients enrolled in FLASH.BackgroundHigh‐ and intermediate‐risk PEs are characterized by high mortality rates, frequent readmissions, and long‐term sequelae. Mechanical thrombectomy is emerging as a front‐line therapy for PE that enables immediate thrombus reduction while avoiding the bleeding risks inherent with thrombolytics.MethodsThe primary endpoint is a composite of major adverse events (MAE) including device‐related death, major bleeding, and intraprocedural device‐ or procedure‐related adverse events at 48 h. Secondary endpoints include on‐table changes in hemodynamics and longer‐term measures including dyspnea, heart rate, and cardiac function.ResultsPatients were predominantly intermediate‐risk per ESC guidelines (6.8% high‐risk, 93.2% intermediate‐risk). There were three MAEs (1.2%), all of which were major bleeds that resolved without sequelae, with no device‐related injuries, clinical deteriorations, or deaths at 48 h. All‐cause mortality was 0.4% at 30 days, with a single death that was unrelated to PE. Significant on‐table improvements in hemodynamics were noted, including an average reduction in mean pulmonary artery pressure of 7.1 mmHg (22.2%, p < 0.001). Patient symptoms and cardiac function improved through follow‐up.ConclusionsThese interim results provide preliminary evidence of excellent safety in a real‐world PE population. Reported outcomes suggest that mechanical thrombectomy can result in immediate hemodynamic improvements, symptom reduction, and cardiac function recovery.
Bilateral basal ganglia infarction and bilateral thalamic lesions in sudanese pediatric patient with COVID‐19 and malaria co‐infection, a case report
Authors: Abdelrahim Abdalla Yassin , Abdalfdeel Almahie Shaban Mohannad , Abbasher Hussien Mohamed Ahmed Khabab , Haroun Mazin S. , Eljack Moh. Mah. Fadelallah , Sidahmed Eltom Khalid , Sidahmed Elhassan Rasha 
Published: February 2022

AbstractCOVID‐19 is of uncommon diagnosis in pediatric with their presentation in much of time of a non‐specific entity; here, we experienced the case of a 2‐year‐old female with malaria presented with fever, cough, rhinorrhea, hemoptysis, and convulsion diagnosed as COVID‐19, complicated with encephalitis, received treatment, and improved over weeks.
Novel lead anchor technique using an active fixation quadripolar left ventricular lead in cardiac resynchronization therapy
Authors: Inamura Yukihiro , Inaba Osamu , Sato Akira , Nitta Junichi , Goya Masahiko , Sasano Tetsuo 
Published: February 2022

AbstractIn this report, we present a case of successful advancement of a LV lead into tortuous vessels. This was achieved by deep engagement of the coronary sinus with a cannulation catheter by applying the anchor technique using the Medtronic Attain Stability Quad lead.
A case of acute exacerbation of chronic hepatitis C during the course of adrenal Cushing's syndrome
Authors: Osuga Takahiro , Miyanishi Koji , Hamaguchi Kota , Tanaka Shingo , Ohnuma Hiroyuki , Murase Kazuyuki , Takada Kohichi , Kato Junji 
Published: February 2022

AbstractA 50‐year‐old woman with adrenal Cushing's syndrome and chronic hepatitis C developed an acute exacerbation of chronic hepatitis C before adrenectomy. After administration of glecaprevir/pibrentasvir was started, her transaminase levels normalized promptly and a rapid virological response also was achieved. Laparoscopic left adrenectomy was then performed safely.
Abdominal aortic aneurysm mimicking the cause of gastric obstruction
Authors: Ishida Shinichi , Ihara Tsutomu 
Published: February 2022

AbstractA case of abdominal aortic aneurysm appeared to be compression of the antrum of the stomach and was suspected of causing a gastric obstruction. However, an upper gastrointestinal endoscopy to rule out an obstruction by a tumor revealed a gastric tumor, thus avoiding unnecessary intervention, such as open surgery.
One‐Pot Chemical Protein Synthesis Utilizing Fmoc‐Masked Selenazolidine to Address the Redox Functionality of Human Selenoprotein F**
Authors: Zhao Zhenguang , Mousa Reem , Metanis Norman 
Published: February 2022

AbstractHuman SELENOF is an endoplasmic reticulum (ER) selenoprotein that contains the redox active motif CXU (C is cysteine and U is selenocysteine), resembling the redox motif of thiol‐disulfide oxidoreductases (CXXC). Like other selenoproteins, the challenge in accessing SELENOF has somewhat limited its full biological characterization thus far. Here we present the one‐pot chemical synthesis of the thioredoxin‐like domain of SELENOF, highlighted by the use of Fmoc‐protected selenazolidine, native chemical ligations and deselenization reactions. The redox potential of the CXU motif, together with insulin turbidimetric assay suggested that SELENOF may catalyze the reduction of disulfides in misfolded proteins. Furthermore, we demonstrate that SELENOF is not a protein disulfide isomerase (PDI)‐like enzyme, as it did not enhance the folding of the two protein models; bovine pancreatic trypsin inhibitor and hirudin. These studies suggest that SELENOF may be responsible for reducing the non‐native disulfide bonds of misfolded glycoproteins as part of the quality control system in the ER.
Repo‐Pak – Die Zukunft des Paketversands
Authors: Richter Lukas , Poppe Tom , Beeskow Philipp , Jaske Jonas , Neugebauer Paul 
Published: February 2022

AbstractKunststoffe sind vor allem als Verpackungen aus dem Alltag nicht wegzudenken. Die teilweise unkontrolliert in die Biosphäre gelangenden oder sonst zumeist verbrannten Abfälle stellen eine große Belastung des Ökosystems dar. Im Rahmen des 4. chemPLANT‐Wettbewerbs 2021 der kreativen jungen Verfahrensingenieure (kjVI) der VDI‐Gesellschaft Verfahrenstechnik und Chemieingenieurwesen (VDI‐GVC) mit Fokus auf “Zirkuläre Wertschöpfung” präsentierten elf Teams aus acht Hochschulen moderne Recyclingverfahren. Das Team des Karlsruher Instituts für Technologie (KIT) überzeugte mit einer Kombination aus ganzheitlichem Recycling und nachhaltiger Produktentwicklung.
Simulation der MacGyver‐Idee gegen Schadstoffe
Authors: Keatley Rachel 
Published: February 2022

AbstractJeden Tag gelangen Mikroverunreinigungen in die Seen, Flüsse und Bäche der Welt. Viele herkömmliche Kläranlagen sind nicht in der Lage, diese potenziell gefährlichen chemischen Rückstände aus dem Abwasser zu entfernen. Eden Tech, ein Deeptech‐Unternehmen mit Sitz in Paris, Frankreich, setzt Multiphysik‐Simulationen ein, um ein Gerät zu entwickeln, das bei diesem Problem helfen kann.
Für eine mikroplastikfreie Produktion
Authors: Haubensak Silke , Schuhen Katrin 
Published: February 2022

AbstractGesetzliche Regulationen gegen den bislang ungehinderten Eintrag von in die Umwelt zeichnen sich ab. Gleichzeitig steigen die Kosten der industriellen Wasserreinigung. Für viele der kunststofferzeugenden, ‐verarbeitenden und entsorgenden Unternehmen bedeutet das eine Neuausrichtung ihres Abwasser‐ und Ressourcenmanagements. Das Verfahren Wasser 3.0 PE‐X ist ein vielversprechender Ansatz für ein nachhaltiges und kosteneffizientes Sustainability Upgrading von industriellen Prozessen, um Mikroplastik und andere Partikel mit einer einfachen und hocheffizienten Materialkombination aus Wasser zu entfernen.
Upsides and downsides of a telecounselling model of integrated asthma management between general practitioners and specialists
Authors: Furci Fabiana , Caminati Marco , Genovese Sara , Gangemi Sebastiano , Senna Gianenrico 
Published: February 2022

AbstractBackgroundAsthma control, one of the most important goals in the management of asthmatic patients, requires good adherence to guidelines and support at a territorial level, in particular on the part of general practitioners (GPs). A territorial hospital alliance can become a strength in asthma management, where control by GPs can also be carried out through a spirometric examination.MethodsThe realisation of a telecounselling model management of asthma between GPs and specialists was the aim of this study, to understand how to obtain good asthma control. A specific digital platform, the PneumoApp platform, was used for the insertion of clinical data and flow volume (F‐V) curves, performed in asthmatic patients by GPs, and for the subsequent evaluation of these data by specialists.ResultsGPs have shown to be able to perform a check‐up of respiratory function well using a portable spirometer, but the analysis of the collected data showed that GP assessment of the severity level of asthma is incorrect in patients with moderate‐severe asthma.ConclusionsThe effectiveness of a telecounselling collaboration between hospital and territory in the management of asthma patients can be improved by greater diffusion of the use of Global Initiative for Asthma (GINA) guidelines at a local level.
Transparent subsidized agri‐product distribution during pandemics with reputation based PoA blockchain
Authors: Bala Kirti , Kaur Pankaj Deep 
Published: February 2022

SummaryTechnological advancements play a crucial role in agriculture sector aiming at eradicating numerous problems. These problems are intensified due to pandemics like delay overhead in the subsidized agri‐products supply chains. The existing technology‐based solutions are not readily adopted by stakeholders due to absence of trust. Blockchain can impart more transparency and trust in agri‐supply chains leading to fair pricing. The idea of using blockchain for financing processes in agriculture has resulted from the managerial pressure and fiscal scams which eventually aggravate the plight of farmers. Thus, a blockchain‐based subsidized agri‐products distribution (SAPD) is proposed. Blockchain has been optimized by a reputation‐based Proof‐of‐Authority (PoA) consensus algorithm. It has been implemented using Ethereum blockchain on AWS EC2 cloud. The smart contract is designed in solidity. Detailed performance evaluation has been conducted to compute cost and processing time that shows a substantial reduction in cost of managerial operations with respect to previous work by 41.65%. Finally, to assess the utility of SAPD system a qualitative user survey has been conducted. Managerial significance of system is reflected in memory space reduction by 85% in light clients and increase in transaction execution per second by 31% using reputation‐based PoA.
A Sensitive and Quantitative Assay to Enumerate and Measure Mycobacterium leprae Viability in Clinical and Experimental Specimens
Authors: Collins Jaymes H. , Lenz Shannon M. , Ray Nashone A. , Balagon Marivic F. , Hagge Deanna A. , Lahiri Ramanuj , Adams Linda B. 
Published: February 2022

AbstractMycobacterium leprae, the etiologic agent of leprosy, cannot be cultured on artificial media. This characteristic, coupled with its long generation time, presents a number of unique challenges to studying this pathogen. One of the difficulties facing both researchers and clinicians is the absence of a rapid test to measure the viability of M. leprae in clinical or experimental specimens. The lack of such a tool limits the understanding of M. leprae immunopathogenesis and makes determining the efficacy of drug treatments difficult. With this in mind, we developed a robust two‐step molecular viability assay (MVA) that first enumerates the M. leprae in the tissue; then, this data is used to normalize bacterial RNA quantities for the second step, in which the expression of M. leprae esxA and hsp18 are measured. This assay is specific and sensitive enough to be used on most clinical samples. This protocol describes the steps required to extract DNA and RNA from M. leprae‐infected tissue, enumerate M. leprae, and measure M. leprae viability based on the normalized expression of two M. leprae‐specific genes (hsp18 and esxA). This protocol also outlines an optimal laboratory design and workflow for performing this assay. © 2022 The Leprosy Mission Nepal. Current Protocols published by Wiley Periodicals LLC. This article has been contributed to by US Government employees and their work is in the public domain in the USA.This article was corrected on 19 February 2022. See the end of the full text for details.Basic Protocol 1: DNA and RNA P purification from M. leprae‐infected tissueBasic Protocol 2: Enumeration of M. leprae by RLEP qPCR on the DNA fractionBasic Protocol 3: Calculation of M. leprae per tissue and normalization of RNABasic Protocol 4: Reverse‐transcription of normalized RNA to generate cDNABasic Protocol 5: Determination of M. leprae viability using HSP18 and ESXA qPCR on the cDNASupport Protocol 1: M. leprae qPCR primer/probe stock preparationSupport Protocol 2: Preparation of plasmid stocks and standard curves
High mobility enabled spatial and media‐based modulated orthogonal frequency division multiplexing systems for beyond 5G wireless communications
Authors: Başaran Mehmet , Başar Ertuğrul , Çırpan Hakan Ali 
Published: February 2022

SummaryThis paper introduces the concept of spatial and media‐based modulated (SMBM) orthogonal frequency division multiplexing (OFDM) as a potential candidate for highly mobile next generation beyond 5G (B5G) wireless communications. The proposed SMBM‐OFDM technique utilizes not only the transmit antenna and channel state indices but also OFDM subcarriers to improve the system performance under high mobility. In addition, this study sheds light on challenging fast time‐varying channel estimation problem of MBM‐based systems by using the linear minimum mean square error (LMMSE) approach due to its optimality to investigate the achievable system performance with the aid of basis expansion modeling. The minimum lower bound on the channel estimation error (Bayesian Cramer–Rao bound) is derived theoretically and shown to be attainable by the considered LMMSE estimator. Moreover, symbol detection performance is provided for different modulation types and higher mobile velocities. Simulation results demonstrate that SMBM‐OFDM system under high mobility is able to provide around 12‐dB performance gains in terms of both channel estimation and symbol detection error compared to conventional spatial modulation (SM)‐OFDM systems without MBM. The presented framework is important due to addressing the high mobility support of SMBM‐OFDM systems for B5G wireless communications in terms of achievable channel estimation and data detection performance.
Simulated treatment effects on bird communities inform landscape‐scale dry conifer forest management
Authors: Latif Quresh S. , Cannon Jeffery B. , Chabot Eric J. , Sparks Robert A. 
Published: February 2022

AbstractHuman land use and climate change have increased forest density and wildfire risk in dry conifer forests of western North America, threatening various ecosystem services, including habitat for wildlife. Government policy supports active management to restore historical structure and ecological function. Information on potential contributions of restoration to wildlife habitat can allow assessment of tradeoffs with other ecological benefits when prioritizing treatments. We predicted avian responses to simulated treatments representing alternative scenarios to inform landscape‐scale forest management planning along the Colorado Front Range. We used data from the Integrated Monitoring in Bird Conservation Regions program to inform a hierarchical multispecies occupancy model relating species occupancy and richness with canopy cover at two spatial scales. We then simulated changes in canopy cover (remotely sensed in 2018) under three alternative scenarios, (1) a “fuels reduction” scenario representing landscape‐wide 30% reduction in canopy cover, (2) a “restoration” scenario representing more nuanced, spatially variable treatments targeting historical conditions, and (3) a reference, no‐change scenario. Model predictions showed areas of potential gains and losses for species richness, richness of ponderosa pine forest habitat specialists, and the ratio of specialists to generalists at two (1 km2 and 250 m2) spatial scales. Under both fuels reduction and restoration scenarios, we projected greater gains than losses for species richness. Surprisingly, despite restoration more explicitly targeting ecologically relevant historical conditions, fuels reduction benefited bird species richness over a greater spatial extent than restoration, particularly in the lower montane life zone. These benefits reflected generally positive species associations with moderate canopy cover promoted more consistently under the fuels reduction scenario. In practice, contemporary forest management is likely to lie somewhere between the fuels reduction and restoration scenarios represented here. Therefore, our results inform where and how active forest management can best support avian diversity. Although our study raises questions regarding the value of including landscape‐scale heterogeneity as a management objective, we do not question the value of targeting finer scale heterogeneity (i.e., stand and treatment level). Rather, our results combined with those from previous work clarify the scale at which targeting structural heterogeneity and historical reference conditions can promote particular ecosystem services.
Substrate and pH‐dependent homogeneous electrocatalysis using riboflavin for oxygen reduction
Authors: Leeb Elisabeth , Wielend Dominik , Schimanofsky Corina , Sariciftci Niyazi Serdar 
Published: February 2022

AbstractHomogeneous, aqueous solutions of the natural compound riboflavin were investigated for their electrocatalytic oxygen to hydrogen peroxide (H2O2) reduction performance using cyclic voltammetry and electrolysis. In addition to pH dependencies, interestingly the choice of carbon‐based electrode material had a strong impact on the electrocatalytic performance. Therefore, the three electrode materials, glassy carbon, carbon paper (CP), and carbon felt were electrochemically compared and afterwards investigated with scanning electron microscopy. Attributed to the deprotonation of riboflavin, pH = 13 was identified as the best performing condition. Using CP at pH = 13, the addition of riboflavin enhanced the H2O2 production by a factor of 14 up to 355 μmol after 6 h at an average faradaic efficiency of around 80%.