bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Rare Neck Pathology in Children; Congenital Sıalocutanous Fistule: A Case Report
Authors: Deniz Muhammed Akif 
Published: May 2022

Introduction/Background:
In this article, we aimed to present a congenital sialocutaneous
fistula originating from the parotid gland in a 4-year-old child with MR findings.

Case Presentation:
A 4-year-old male patient was admitted to our clinic with a small hole in the inferior
right half of the neck and a sticky fluid coming out of this area. Neck ultrasonography (US) and
contrast neck Magnetic Resonance Imaging (MRI) were performed on the patient.
In the US, a millimeter linear, vaguely hypoechoic appearance was observed in the subcutaneous tissue
at this level on the neck. In contrast-enhanced neck MRI imaging, at the level of the right parotid tail, a
millimetric linear fistula tract was observed, which was thought to originate from the superficial parotid
lobe and extended to the skin at the proximal level of the right sternocleidomastoid (SCM) muscle.
After suppressing surrounding fatty tissues in fat-suppressed contrast-enhanced series, this tract area
became slightly pronounced.

Conclusion:
In conclusion, sialocutaneous fistula should be considered among the differential diagnoses
in cases of skin fistulization in children. In terms of differential diagnosis, MRI is a very effective
imaging method due to its high soft-tissue resolution.
L-Proline Catalyzed Knoevenagel Condensation of Aldehydes with Active
Methylene Compounds and Their Molecular Modeling Studies for
Anti-SARS CoV-2 Potentials
Authors: Thorat Bapu R. , Nagre Dnyaneshwar T. , Dhurandhar Pawan P. , Borase Pratiksha K. , Bavkar Sweta , Kasar Riddhi R. , Narkar Rohan D. , Farooqui Mazhar , Mali Suraj N. 
Published: May 2022

Introduction:
An efficient one-pot synthesis of 2-alkylidene/arylidene derivatives was reported
from active methylene compounds such as malononitrile/ethyl cyanoacetate/5-methyl-2,4-
dihydro-3H-pyrazol-3-one and aldehydes in the presence of 10 mol% of L-proline (ethanol at room
temperature).

Methods:
All derivatives were obtained in good to excellent yields. The structures of the synthesized
compounds were confirmed from their FTIR (Fourier-transform infrared spectroscopy), 1H-NMR (Proton
nuclear magnetic resonance), and mass spectroscopy. The importance of these compounds is predicted
from their SAR (structure-activity relationship) study. Moreover, these newer compounds were
further docked into various therapeutic targets of the SARS-CoV-2 (severe acute respiratory syndromerelated
coronavirus) virus.

Results:
Results from our molecular docking suggest that these compounds have good inhibitory properties
on the SARS- CoV-2 virus.

Conclusion:
L-proline (bifunctional organic catalyst) is found to be the best catalyst for the synthesis of
different condensed products from active methylene compounds and aldehydes.
Erythroxylum cuneatum Prevented Cellular Adaptation in Morphineinduced
Neuroblastoma Cells
Authors: Moklas Mohamad Aris Mohd , Suliman Noor Azuin , Taib Che Norma Mat , Hidayat Baharuldin Mohamad Taufik , Chiroma Musa Samaila 
Published: May 2022

Background:
Chronic morphine stimulates prolonged stimulation of opioid receptors,
especially μ-opioid subtype (MOR), which in turn signals cellular adaptation. However, the
sudden termination of the use of morphine after chronic intake causes the withdrawal syndrome.

Objectives:
Hence, this study was designed to find an alternative treatment for morphine
withdrawal using the alkaloid leaf extract of Erythroxylum cuneatum (E. cuneatum) for the
treatment of morphine-exposed neuroblastoma cell lines.

Methods:
SK-N-SH, a commercialised neuroblastoma cell line, was used in two separate study
designs; the antagonistic and pre-treatment of morphine. The antagonistic treatment was conducted
through concurrent exposure of the cells to morphine and E. cuneatum or morphine and methadone
for 24 hrs. The pre-treatment design was carried out by exposing the cells to morphine for 24 hrs,
followed by 24 hrs exposure to E. cuneatum or methadone. The cytosolic fraction was collected
and assessed for proteins expression involved in cellular adaptation, including mitogen-activated
protein (MAP)/extracellular signal-regulated (ERK) kinase 1/2 (MEK 1/2), extracellular signalregulated
kinase 2 (ERK 2), cAMP-dependent protein kinase (PKA) and protein kinases C (PKC).

Results:
The antagonistic treatment showed the normal level of MEK 1/2, ERK 2, PKA and PKC
by the combination treatment of morphine and E. cuneatum, comparable to the combination of
morphine and methadone. Neuroblastoma cells exposed to morphine pre-treatment expressed a
high level of MEK 1/2, ERK 2, PKA and PKC, while the treatments with E. cuneatum and methadone
normalised the expression of the cellular adaptation proteins.

Conclusion:
E. cuneatum exerted anti-addiction properties by lowering the levels of cellular adaptation
proteins it’s effects is comparable to that of methadone (an established anti-addiction drug).
Treatment of Major Depression with Psychotic Features and Cotard’s
Syndrome after COVID-19 Infection in a Previously Healthy Patient: A
Case Report
Authors: Aytac Hasan Mervan 
Published: May 2022

Background:
COVID-19 pandemic is related to anxiety, depression, and psychotic symptoms
either directly due to invasion or inflammation caused by the virus or indirectly due to related
psychosocial stress: fear of infection, social isolation, and financial burden.

Case Presentation:
We present a 28-year-old female case of post‐COVID major depression with psychotic
features and Cotard’s syndrome with no previous psychiatric history. Her complaints initially
described the sadness of mood with early morning worsening, diminished interest in almost all activities,
anhedonia, increased anxiety, ideas of worthlessness, hopelessness, guilt, decreased sleep, and appetite.
Then, she developed severe depression with psychotic features such as delusions of persecution, poverty,
and nihilism. Nihilistic delusions included a description of everything coming to an end. She thought that
her organs were no more working. Later, she negated her existence and started believing that she was
dead. The patient recovered after a combination of sertraline and olanzapine treatment.

Conclusions:
This case of a COVID-19 patient with psychotic depression and Cotard’s delusion highlights
the importance of evaluating mental health status and may contribute to our understanding of the
potential risk of central nervous system impairment by SARS-CoV-2 infection.
Effective Connectivity Between the Orbitofrontal Cortex and the Precuneus
Differentiates Major Psychiatric Disorders: Results from a Transdiagnostic
Spectral DCM Study
Authors: Rema João Paulo , Novais Filipa , Telles-Correia Diogo 
Published: May 2022

Abstract:
Translational psychiatry has been a hot topic in neurosciences research. The authors present
a commentary on the relevant findings from a transdiagnostic study applicable to clinic practice. Additional
discussion on conceptual and clinical insight into this current broad line of research is explored
in the integration of multi-level paradigm in Psychiatry research.
Analysis of Gravity-Filtration Preparation Methods’ Antioxidant Content, Capacity, and Coffee Beverage Acceptance
Authors: Ormaza-Zapata Angela María , Díaz-Arango Félix Octavio , Rojano Benjamín Alberto 
Published: May 2022

Most gravity-filtration coffee preparation methods constitute good alternatives for obtaining coffee with varying acidity, bitterness, and bodies. The present study identifies the composition of compounds with antioxidant capacities and cup profiles for coffee beverages prepared using eight gravity-filtration methods. UV-visible spectrophotometry and high-performance liquid chromatography quantified antioxidants, hydroxycinnamic acids, and antioxidant activity. A qualitative descriptive analysis was performed using an expert panel to establish the sensory quality. The methods that yielded the highest total phenol and flavonoid concentrations were Chemex, Siphon, and Silvertone. The Silvertone, Siphon, and Neapolitan methods had the most condensed tannin content. The maximum hydroxycinnamic acid content was found with the Siphon and Neapolitan methods. Antioxidant capacity was evaluated by the ABTS (antioxidant capacity of the cationic radical 2,2-Azino-bis-3-ethylbenzthiazoline-6-sulfonic acid), ORAC (Oxygen Radical Absorption Capacity), and FRAP (Ferric Reducing Antioxidant Power) methods and found to be the highest with the Silvertone, Siphon, and Neapolitan methods. The preparation methods with the highest sensorial scores were Silvertone and Chemex, while the lowest sensorial acceptance level was found with the Cloth filter method. Beverages made with the Kalita and Drip methods showed the lowest antioxidant compound expressions. The most predominant hydroxycinnamic acid was chlorogenic acid in the eight preparations studied. We thus recommend that coffee be consumed following preparation with the Silvertone, Siphon, or Neapolitan methods to increase antioxidant consumption in the diet. Should the consumer prefer bitter notes, these may be found with the Silvertone preparation method; otherwise, one may enjoy acidic notes in coffee beverages with the Siphon and Neapolitan methods.
Profil Kontrol Glikemik Antidiabetik pada Pasien DM Tipe 2 dengan Sirosis Hati
Authors: Oktaviani Emy , Indriani Lusi , Wulandari Haryanti 
Published: May 2022

Diabetes mellitus (DM) is a metabolic syndrome with multi-etiology characterized by chronic hyperglycemia. DM can cause a variety of complications, one of which is impaired liver function. The use of antidiabetics needs to get more attention because most antidiabetics are metabolized in the heart. This study aims to determine the control of antidiabetic glycemic, the relationship of antidiabetic types with effectiveness, as well as factors related to glycemic control in type 2 DM patients with liver cirrhosis. This research was conducted in June-July at Fatmawati Central General Hospital with cross sectional design and data retrieval period of 2014-2019 conducted retrospectively. The observation parameters of glucose control in this study were current blood sugar (GDS). Of the 106 patients who met the inclusion criteria, it was seen that the use of insulin aspart single in 34 patients showed good glycemic control followed by the use of combination insulin glargine-aspart in 25 patients. The results of the Chi-square analysis showed that there was no significant relationship between the type of antidiabetic on glycemic control (p-value = 0,159). However, the results of the Chi-square test showed that there was a significant relationship between the severity of liver cirrhosis and glycemic control (p-value=0,021) and gender was another factor that also showed a significant relationship to glycemic control (p-value=0,042). The use of insulin aspart alone or in combination with insulin glargine is the best in controlling blood sugar levels while in T2DM patients with liver cirrhosis based on this study.
Las reformas financieras en México. Crédito bancario sin moneda única
Authors: Correa Eugenia 
Published: May 2022

El Tratado de Libre Comercio de América del Norte (TLCAN) no es sólo un acuerdo que abarca productos básicos comercializables, sino que incluye importantes capítulos sobre servicios, especialmente servicios financieros. Adicionalmente, el TLCAN es también un acuerdo pionero para la protección de las inversiones. La libre circulación de capitales y la salvaguarda de los derechos de propiedad son características esenciales. Este artículo sostiene que la reforma financiera en México de 1989 a 1992 fue una condición previa para la liberalización comercial y financiera en el marco del TLCAN. Así, se analiza el contenido de esta reforma y se compara con la llevada a cabo durante la década de 1970, que también abrió el mercado financiero. Posteriormente, se examina el establecimiento de filiales financieras y el modelo global de negocios financieros y sus consecuencias en el financiamiento. Y aunque no se trata de una unión monetaria, el TLCAN establece una forma de unión financiera. Para México, esta unión significa una delimitación del financiamiento global y nacional. Se argumenta que la regionalización del crédito es fantasiosa, ya que ésta pretende establecer una restricción a la capacidad crediticia del banco central frente al gobierno y transferir dicha capacidad al mercado. La idea de sustituir el papel del banco central como prestamista de última instancia, a través de cambios legislativos, y bajo el contexto del actual clima financiero de "<em>too-big-to-fail</em>", no puede contar con el apoyo de un sistema financiero globalizado que opera con monedas nacionales o regionales.<br /><div><div><p> </p></div></div>
La acumulación por desposesión en Puerto Rico: Siglo XXI
Authors: Díaz Ayala Lizamell Judith 
Published: May 2022

El objetivo principal de este texto es explicar cómo se manifiesta la acumulación por desposesión, término propuesto por David Harvey, en el caso de Puerto Rico durante el siglo XXI. Como primer paso, se revisó las categorías generadas por Karl Marx, David Harvey y Saskia Sassen que explican el desarrollo de un fenómeno que comparte la misma lógica de la acumulación originaria. En segundo lugar, desde esta perspectiva de análisis, se estudió tanto fuentes académicas como periodísticas que explican el desarrollo histórico de la actual crisis económica, sociocultural y política en Puerto Rico. Este análisis nos muestra la relación de complicidad, aunque de vez en cuando expresen anecdóticas diferencias, entre el gobierno de Puerto Rico, el de Estados Unidos y el sector financiero.
A NOVEL QUATERNARY ALKALOID N-METHYLCORYXIMINE FROM HYPECOUM PENDULUM L.
Authors: METE Ergün , Kayalar Hüsniye 
Published: May 2022

Objective: In this study, the isolation and chemical structure elucidation of a new alkaloid from Hypecoum pendulum L is provided.
Material and Methods: Column and ascending preparative thin layer chromatographic methods were utilized for the purification of the novel compound. The structure elucidation was determined based on spectroscopic methods including infrared (IR), nuclear magnetic resonance (NMR), and Mass (MS) spectroscopy.
Results: N-methylcoryximine, a quaternary alkaloid from secoberbine subgroup of isoquinoline alkaloids, was isolated and the structure of this compound was elucidated.
Conclusion: The natural occurrence and spectral data of N-methylcoryximine is reported for the first time.

Peer Review History:
Received: 7 March 2022; Revised: 12 April; Accepted: 29 April, Available online: 15 May 2022
Academic Editor: Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, olorunsolaeo@yahoo.com
UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622, Giza, Egypt, gehankandeel9@yahoo.com
Dr. Nazim Hussain, North East Frontier Technical University, Arunachal pradesh, India, nhussain116@gmail.com
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