bluuebunny/crossref_metadata_2025_split huggingface dataset:
High titers of antinuclear antibody and the presence of multiple autoantibodies are highly suggestive of systemic lupus erythematosus
Authors: Li Hejun , Zheng Yiqing , Chen Ling , Lin Shunping 
Published: February 2022

AbstractThe aim of this study is to evaluate the relationship between antinuclear antibody (ANA) titer and specificity, as well as the relationship between the number of positive-autoantibodies (AAbs) in antinuclear antibodies (ANAs) and specificity for systemic lupus erythematosus (SLE), so as to explore their significance in the diagnosis of SLE. A total of 1297 patients with ANA results was enrolled in this study, including 148 patients with SLE patients. The sensitivity, specificity, sensitive likelihood ratio and specific likelihood ratio of indicators in SLE were determined by receiver–operator characteristic (ROC) curve after measurement of ANA and ANAs by indirect immunofluorescence (IIF) and immunoblotting, respectively. ROC analysis showed that the specificity of ANA titer ≥ 1 +, ≥ 2 + and ≥ 3 + for SLE was estimated to be 81.29%, 90.69% and 96.52% respectively, with a increased titer-specific likelihood ratio (5.16, 9.29 and 19.60, respectively). The specificity of the number of positive-AAbs ≥ 1, ≥ 2 and ≥ 3 in ANAs for SLE was estimated to be 80.42%, 94.95% and 99.3% respectively, with a increased number-specific likelihood ratio (4.8, 15.26 and 72.48, respectively). The estimated sensitivity of the number of positive-AAbs ≥ 3, AnuA and anti-rRNP was higher than that of anti-Sm (p < 0.01) (50.68%, 41.89% and 31.76% vs. 16.89%, respectively), while there was no significant difference in their specificity (99.3%, 99.74% and 99.56% vs. 99.74%, respectively) (p > 0.05). High titers of ANA and the presence of multiple AAbs in ANAs are highly specific for SLE and highly suggestive of SLE. The likelihood of SLE can be assessed by ANA titer and the number of positive-AAbs in ANAs.
Arctic warming-induced cold damage to East Asian terrestrial ecosystems
Authors: Kim Jin-Soo , Kug Jong-Seong , Jeong Sujong , Yoon Jin-Ho , Zeng Ning , Hong Jinkyu , Jeong Jee-Hoon , Zhao Yuan , Chen Xiaoqiu , Williams Mathew , Ichii Kazuhito , Schaepman-Strub Gabriela 
Published: February 2022

AbstractThe global mean temperature is increasing due to the increase in greenhouse gases in the atmosphere, but paradoxically, many regions in the mid-latitudes have experienced cold winters recently. Here we analyse multiple observed and modelled datasets to evaluate links between Arctic temperature variation and cold damage in the East Asian terrestrial ecosystem. We find that winter warming over the Barents-Kara Sea has led to simultaneous negative temperature anomalies over most areas in East Asia and negative leaf area index anomalies in southern China where mostly subtropical evergreen forests are growing. In addition to these simultaneous impacts, spring vegetation activity and gross primary productivity were also reduced over evergreen and deciduous trees, and spring phenological dates are delayed. Earth System model simulations reveal that cold damage becomes stronger under greenhouse warming; therefore Arctic warming-induced cold stress should be considered in forest and carbon management strategies.
Exploring rhizo-microbiome transplants as a tool for protective plant-microbiome manipulation
Authors: Jiang Gaofei , Zhang Yuling , Gan Guiyun , Li Weiliu , Wan Wen , Jiang Yaqin , Yang Tianjie , Zhang Yong , Xu Yangchun , Wang Yikui , Shen Qirong , Wei Zhong , Dini-Andreote Francisco 
Published: February 2022

Abstract
The development of strategies for effectively manipulating and engineering beneficial plant-associated microbiomes is a major challenge in microbial ecology. In this sense, the efficacy and potential implications of rhizosphere microbiome transplant (RMT) in plant disease management have only scarcely been explored in the literature. Here, we initially investigated potential differences in rhizosphere microbiomes of 12 Solanaceae eggplant varieties and accessed their level of resistance promoted against bacterial wilt disease caused by the pathogen Ralstonia solanacearum, in a 3-year field trial. We elected 6 resistant microbiomes and further tested the broad feasibility of using RMT from these donor varieties to a susceptible model Solanaceae tomato variety MicroTom. Overall, we found the rhizosphere microbiome of resistant varieties to enrich for distinct and specific bacterial taxa, of which some displayed significant associations with the disease suppression. Quantification of the RMT efficacy using source tracking analysis revealed more than 60% of the donor microbial communities to successfully colonize and establish in the rhizosphere of recipient plants. RTM from distinct resistant donors resulted in different levels of wilt disease suppression, reaching up to 47% of reduction in disease incidence. Last, we provide a culture-dependent validation of potential bacterial taxa associated with antagonistic interactions with the pathogen, thus contributing to a better understanding of the potential mechanism associated with the disease suppression. Our study shows RMT from appropriate resistant donors to be a promising tool to effectively modulate protective microbiomes and promote plant health. Together we advocate for future studies aiming at understanding the ecological processes and mechanisms mediating rates of coalescence between donor and recipient microbiomes in the plant rhizosphere.
Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms
Authors: Tan Lunbo , Chen Zhilong , Sun Fen , Zhou Zhuoqun , Zhang Baozhen , Wang Baobei , Chen Jie , Li Mengxia , Xiao Tianxia , Neuman Rugina I. , Niu Jianmin , Verdonk Koen , Lu Xifeng , Zhang Jian V. , Danser A.H. Jan , Yang Qing , Fan Xiujun 
Published: February 2022

Abstract
Maternal circulating levels of the adipokine chemerin are elevated in preeclampsia, but its origin and contribution to preeclampsia remain unknown. We therefore studied (1) placental chemerin expression and release in human pregnancy, and (2) the consequences of chemerin overexpression via lentivirus-mediated trophoblast-specific gene manipulation in both mice and immortalized human trophoblasts. Placental chemerin expression and release were increased in women with preeclampsia, and their circulating chemerin levels correlated positively with the soluble Fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio, a well-known biomarker of preeclampsia severity. Placental trophoblast chemerin overexpression in mice induced a preeclampsia-like syndrome, involving hypertension, proteinuria, and endotheliosis, combined with diminished trophoblast invasion, a disorganized labyrinth layer, and up-regulation of sFlt-1 and the inflammation markers nuclear factor-κB (NFκB), tumor necrosis factor (TNF)-α, and interleukin (IL)-1β. It also led to embryo resorption, while maternal serum chemerin levels correlated negatively with fetal weight in mice. Chemerin overexpression in human trophoblasts up-regulated sFlt-1, reduced vascular endothelial factor-A, and inhibited migration and invasion, as well as tube formation during co-culture with human umbilical vein endothelial cells (HUVECs). The chemokine-like receptor 1 (CMKLR1) antagonist α-NETA prevented the latter phenomenon, although it did not reverse the chemerin-induced down-regulation of the phosphoinositide 3-kinase/Akt pathway. In conclusion, up-regulation of placental chemerin synthesis disturbs normal placental development via its CMKLR1 receptor, thereby contributing to fetal growth restriction/resorption and the development of preeclampsia. Chemerin might be a novel biomarker of preeclampsia, and inhibition of the chemerin/CMKLR1 pathway is a promising novel therapeutic strategy to treat preeclampsia.
Underrepresentation of Students From Diverse Backgrounds Entering Communication Sciences and Disorders Programs: An Investigation Into the University Student Perspective
Authors: Richburg Cynthia McCormick 
Published: February 2022

Purpose:
This study investigated university students' knowledge of and attitudes toward the professions of communication sciences and disorders (CSD), with a goal to determine if there were any differences between responses received from minority students compared with responses from White/Caucasian students. The survey collected information about the experiences and exposure that university students have to these professions and professionals before and during their undergraduate years, along with possible reasons male students and students from diverse backgrounds are less likely to enroll in CSD programs.

Method:
Surveys were distributed via Qualtrics and hard copy over 12 weeks of a fall semester to a sample of over 4,000 undergraduate students at a middle-sized public research university in southwest Pennsylvania. Responses were obtained from a total of 524 students.

Results:
In this group of university students, more students reported having obtained information from their high schools regarding speech-language pathology than audiology. More females than males were aware of CSD professions prior to entering college, and non-White students reported knowing less about both the degree programs and professions of audiology and speech-language pathology than their White peers. Neither the non-White group nor males reported much interest in pursuing CSD degrees or professions.

Conclusions:
Non-White students and males reported being exposed less to CSD professions (thus knowing less) than their White and female counterparts, but overall interest in these professions appeared to be lacking for the non-White and male students within this study. Additional research from a larger group of minority and male students nationwide is needed to determine if CSD is universally not attractive to these groups.
Wie der Sonntags-Tatort zum Tode führte …
Authors: Hoffmann Knut , Juckel Georg 
Published: February 2022

ZusammenfassungWir berichten hier über einen besonderen Fall eines Suizids, der sich im zeitlich sehr nahen Anschluss an die Ausstrahlung einer Tatortfolge ereignete und die dort gezeigte Tötungsmethode direkt kopierte. Es wird kritisch das Problem von derartigen Darstellungen auch unabhängig von den üblichen Regeln des Pressekodex diskutiert.
Effects of
Authors: Qin Linlin , Su Guoqi , Wu Cheng , Zhou Qiang , Peng Xie , Hu Liang , Liu Yang , Wang Ru , Xu Qin , Fang Zhengfeng , Lin Yan , Xu Shengyu , Feng Bin , Li Jian , Wu De , Che Lianqiang 
Published: February 2022

Context In-feed antibiotics are commonly used to improve growth and gut health of weaning pigs. Due to anti-microbial resistance by extensively using antibiotics, however, in-feed antibiotics have been banned in Europe and China. Tremella fuciformis is a traditional edible fungus in China. Recent studies have found that Tremella fuciformis extract (TFE) has anti-inflammatory, anti-cancer and immune-modulatory functions. Therefore, there is the potential to develop Tremella fuciformis as an alternative to antibiotics. Aims The study was performed to explore the effects of TFE on growth performance, and biochemical and immunological parameters of weaned piglets under lipopolysaccharide (LPS) challenge. Methods Forty-eight weaned piglets were assigned into two groups with six pens (four piglets per-pen), receiving a control diet or a control diet with 400 mg/kg TFE (TFE), respectively. After 28 days of the trial, two piglets per pen were selected to be injected with LPS (50 μg/kg of BW) or an equivalent amount of sterile saline. Blood samples were collected at 0 and 3 h after LPS challenge. Key results The results showed that TFE supplementation significantly increased the average daily gain (P < 0.05) and decreased the faecal score (P < 0.05) during the first week, improved the feed conversion ratio (P < 0.05) and BWt gain (P < 0.05) during the whole period. Piglets fed the TFE diet had higher plasma levels of white blood cells (P < 0.05) than that of piglets fed the control diet diet before the LPS challenge. Regardless of the dietary treatment, the LPS challenge significantly decreased the level of white blood cells, and increased the levels of red blood cells, haemoglobin, haematocrit, total protein, interleukin-1β and tumour necrosis factor-α (all P < 0.05). Regardless of the LPS challenge, however, the concentrations of total protein, interleukin-1β and tumour necrosis factor-α were decreased (all P < 0.05) in the plasma of piglets fed the TFE diet compared with the control diet diet. Conclusions In summary, the supplementation of TFE in the weaning diet could improve the growth performance and immunity of piglets. Implication TFE could be used as a bioactive substance for improving growth and immune response in pig production.
Marker-assisted selection and validation of DNA markers associated with cadmium content in durum wheat germplasm
Authors: Alsaleh Ahmad , Baloch Faheem Shehzad , Sesiz Uğur , Nadeem Muhammad Azhar , Hatipoğlu Rüştü , Erbakan Mustafa , Özkan Hakan 
Published: February 2022

Cadmium (Cd) is a non-essential heavy metal having toxic effects on all living organisms. Durum wheat (Triticum durum Desf.) is widely used in human diets but has the potential to accumulate Cd. It also has a high level of genetic diversity, which may be exploited to develop cultivars with low Cd content. We aimed to perform marker-assisted selection and validate previously identified Cd markers in durum wheat germplasm for use in the investigation of accessions that accumulate low grain Cd content. We assessed 130 durum wheat accessions phenotypically and using three different molecular markers. Grain Cd contents of the studied germplasm varied 4.91-fold (26.2–128.7 μg/kg) with an average of 58.2 μg/kg. Landraces showed lower average values of grain Cd content than cultivars. Three molecular markers (usw47, Cad-5B and KASP marker Cad-5B) were used to differentiate high and low Cd accumulating lines. Results showed high correlation and successfully classified the accessions to the expected high or low Cd level; 87 accessions showed the low Cd alleles, and 43 accessions the high Cd alleles, except for five accessions with the usw47 marker that showed heterozygous status. A significant correlation coefficient (r = 0.944*) was observed among the three molecular markers. Based on molecular markers, 96.2% of the accessions were classified accurately. The KASP assay was highly effective in successfully separating low from high Cd content accessions and could be used as a molecular tool in durum wheat breeding programs, with less cost and time, targeting reduced grain Cd levels. The results of this study will allow durum wheat breeders to accelerate their progress to select suitable genotypes with the desired alleles.
Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state
Authors: Ghazavi Farzaneh , Huysentruyt Jelle , De Coninck Jordy , Kourula Stephanie , Martens Sofie , Hassannia Behrouz , Wartewig Tim , Divert Tatyana , Roelandt Ria , Popper Bastian , Hiergeist Andreas , Tougaard Peter , Vanden Berghe Tom , Joossens Marie , Berx Geert , Takahashi Nozomi , Wahida Adam , Vandenabeele Peter 
Published: February 2022

Significance
Historically, programmed cell death by apoptosis is considered crucial for proper intestinal organogenesis and gut homeostasis. To challenge this concept, we generated caspase-3 and -7 double knockout mice specifically in intestinal epithelial cells (IECs). However, absence of apoptosis in IECs elicits neither morphological and inflammatory changes nor intestinal dysbiosis during gut homeostasis at steady state. This demonstrates the robustness of intestinal homeostasis at steady state for the absence of caspase-3/7 and shows that in contrast to caspase-8, which keeps necroptosis and associated inflammation in check, caspase-3/7–dependent apoptosis of IECs in homeostatic conditions is dispensable for normal intestinal development, immune cell composition, and microbiome control.
Integration of remote sensing and GIS in the identification of the vegetation covers degradation of the korifla basin (NW of Central Morocco) between 1990 and 2018
Authors: Lahcen D , Hafida N , Souad M , Rachid E H , Bejjaji Z , Mohamed S 
Published: February 2022

Abstract
To characterize the evolution of the vegetation cover in the Korifla basin between 1990 and 2018, and subsequently to reconstitute, understand and explain the climatic and anthropogenic phenomena causing these changes, we adopted a methodological approach combining remote sensing techniques, geographic information systems (GIS) and statistical processing. This work consists of multitemporal satellite images at high and low spatial resolution. After the preprocessing and processing operations of these images and the calculation of the spectral indices NDWI (Normalies difference water index), NDVI (Normalies difference vegetation Index) and BI (Brilliance Index), we have developed multi-temporal maps of the vegetation, water and soil. The establishment and processing of land cover maps (LCM) through the use of the “change detection” application has allowed us to quantify the changes in vegetation cover during the last 28 years in the Korifla basin. As a result, the NDVI maps show that the vegetation cover of the Korifla basin suffered a degradation between the 1990s and 2010 against a regeneration between 2010 and 2018. This last increase is not detectable by the SVM method. As for the “change detection” technique, it confirms the regression of the areas of plant cover between 1990 and 2010 followed by an increase between 2010 and 2015 and relayed by a new regression of these areas between 2015 and 2018.
Slopes of seasonal variations of time series and forecasts: Practical case on weather
Authors: Elamrani H 
Published: February 2022

Abstract
This article introduces a model to develop seasonal time series forecasts based on the stability of the seasonal slopes ofvariation of the successive values of the series in matter at the two successive times. The proposed method is based on the average of the slopes of two successive instants of the same seasons during the periods of this series. The power of this method is derived from the concept of deriving the graph of the time series as an indicator of the direction of its variation. Thus, this model relies on stabilized slopes as steps of variation from an instant to the next. This method developed here is implemented to predict the temperature of the city Basel-Switzerland to show the effectiveness of this model that adopts the derivative of order 1 the series between two successive instants. Taking into account that we have not taken into account all the factors influencing the weather, including the temperature. So, the results obtained will not be accurate enough as possible. in fact, the average difference between the calculated and observed values of temperature was 4.37°C.
Studies of soil degradation, synthetic evaluation of the direct consequences on the landslides of bridges in Southern-Guinea
Authors: Diallo I D , Darraz C , Sidibe D , Tilioua A 
Published: February 2022

Abstract
The lifespans of bridges have become very short in Guinea. They partially collapse, until they fall completely. To understand this scourge and provide some answers, we have conducted more than fifty surveys among neighboring populations and certain professional services (those in charge of studies: climatic; hydrological; agricultural and public works). One problem emerges in common: soil degradation. Lola (border town with the Ivory Coast) is said to have cut itself off from the rest of Guinea after heavy rain. Because? The bridge that linked it to the rest of the country would have collapsed after a complete degradation of its support: the ground. In Kérouané (another city in Guinea), landslides are permanent and cause certain bridges to collapse. The results of our surveys show that with the alternation of the seasons, these soils (lacking scientific and professional studies) undergo degradation and lose their initial states of stability. Our research work and their results support the need for a basic geotechnical study before the start of any project. This could prevent any probable socio-economic impact caused by soil degradation in the regions.
The consumer price index and it effect in the new ecosystems and energy consumption during the sanitary confinement: the case of an emerging country
Authors: Imrani O E , Hamich M , Boulaksili A 
Published: February 2022

Abstract
The country’s economies are undergoing major structural changes as a result of the Covid-19 pandemic. It is mainly due to various businesses managing to limit the distribution of the plague at the levels of industry exchanges and particularly among small-business tradesmen, craft manufacturers, and other sectors of activity. Since the time many countries around the world have lifted their isolation policies, or are about to do so, we wanted to have an up-to-date overview of the current epidemic situation in Morocco in relation to other countries. In addition, we discovered that Morocco’s current epidemic situation has a significant impact on the global level of consumption. The purpose of this piece of writing is to try to find out the effect of government policies on the consumer price index in order to handle the upcoming change in the energy and ecosystem ecosystems.
Landslide Disaster Mapping in Silo District, Jember Regency
Authors: Susetyo J A , Kurnianto F A , Nurdin E A , Pangastuti E I 
Published: February 2022

AbstractSilo District has land with mountainous contours that are relatively unstable and prone to landslides. The factors that cause landslides are complex factors, not only one factor that affects landslides but there are several factors that contribute to the occurrence of a landslide. landslide. The use of five landslide parameters, including rainfall, soil type, slope, land cover and geology. The use of this parameter is adjusted to the physical condition of the silo sub-district. The purpose of this study was to analyze the level of landslide vulnerability in Silo District. The method used is the overlay method with scoring. The scoring of each parameter is based on previous research and the researcher’s modifications are adjusted to the physical conditions of the research location. The data resulting from the overlay process is then classified into three classes, namely areas of landslide vulnerability: low, medium and high. The low classification has a total area of 4266 hectares, the medium classification has an area of 5324 hectares, and the high classification has an area of 659 hectares. Areas with low classification are scattered in the central and northern part of Silo District, namely Silo Village, Sempolan Village and Sumberjati Village. Areas with Medium Classification are spread in the central to southern region which is an area with an old mountainous topography. Meanwhile, areas with a high classification are scattered in the eastern, southern and western regions right around the border with the Banyuwangi Regency border in the east and the old mountainous area in the south and west.