bluuebunny/crossref_metadata_2025_split huggingface dataset:
METTL3-catalyzed m6A methylation facilitates the contribution of vascular smooth muscle cells to atherosclerosis
Authors: Dong Zhigang , Jin Yourong , Shen Yicong , Huang Jiaqi , Tan Jiaai , Feng Qianqian , Gong Ze , Zhu Shirong , Chen Huiyue , Yu Fang , Li Wei , Jia Yiting , Kong Wei , Fu Yi 
Published: February 2025

Abstract

Aims
Vascular smooth muscle cells (VSMCs) are involved in the etiology of atherosclerosis, but whether methyltransferase-like 3 (METTL3)-catalyzed N6-methyladenosine (m6A) modulates the contribution of VSMCs to atherosclerosis remains elusive.

Methods and Results
We generated tamoxifen-inducible VSMC-specific METTL3 knockout mice with VSMC lineage tracing, and found that VSMC-specific METTL3 deficiency substantially attenuated atherosclerosis and reduced the proportion of VSMCs in plaques, due to the inhibition of VSMC atheroprone phenotype as characterized by macrophage-like and inflammatory features as well as high migratory and proliferative capacity. m6A-methylated RNA immunoprecipitation sequencing (MeRIP-Seq) combined with polysome profiling analysis mechanistically displayed METTL3 catalyzed m6A methylation of myocardin-related transcription factor A (MRTFA) mRNA, and further enhanced YTH N6-methyladenosine RNA binding protein F3 (YTHDF3)-dependent MRTFA mRNA translation. Conversely, adenovirus or adeno-associated virus-mediated VSMC-specific MRTFA overexpression abolished METTL3 deficiency-mediated alleviation of VSMC atheroprone phenotypic switching and atherosclerotic progression both in vitro and in vivo.

Conclusion
METTL3 facilitated the contribution of VSMCs to atherosclerosis through the m6A-YTHDF3-dependent MRTFA mRNA translation enhancement.
Simultaneous CardioFlow Optimization to facilitate hemodynamic recovery after rapid ventricular pacing during transcatheter aortic valve implantation – a Case Report
Authors: Jubeh Rami , Asher Elad , Dvir Danny , Glikson Michael , Bruoha Sharon 
Published: February 2025

Abstract

Background
“simultaneous CardioFlow optimization” represents an innovative technique that effectively enhances post pacing hemodynamic recovery during transcatheter aortic valve replacement (TAVR). This technique was applied in two high-risk patients presenting with severe left main trunk stenosis with concomitant severe aortic stenosis and left ventricular dysfunction.

Case summary
an 86-year-old and a 96-year-old patient were admitted with myocardial infarction. Angiography revealed severe left main trunk stenosis, while echocardiography demonstrated significant left ventricular dysfunction and severe aortic stenosis. Both cases were evaluated by the institutional multidisciplinary heart team. Considering the high surgical risk, a percutaneous management strategy was contemplated.

Discussion
We postulated that performing left main truck balloon angioplasty during rapid ventricular pacing would be better tolerated, compared to conventional balloon angioplasty, given the low coronary perfusion pressure at this stage. Additionally, coronary balloon angioplasty is expected to enhance coronary flow in the immediate post-pacing period, thus facilitating hemodynamic recovery. Both patients exhibited prompt improvement in hemodynamics following rapid ventricular pacing and had uncomplicated hospital stays. In patients with significant left main trunk stenosis accompanied by severe aortic stenosis and concomitant left ventricular dysfunction, “simultaneous CardioFlow optimisation” facilitates post pacing hemodynamic recovery.
Visit-to-visit Lipid Variability, Coronary Artery Calcification, Inflammation, and Mortality in the Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Chan Jeffrey Shi Kai , Satti Danish Iltaf , Chan Raymond Ngai Chiu , Chevli Parag , Mehta Adhya , Martin Seth S , Sharma Garima , Tse Gary , Virani Salim S , Shapiro Michael D 
Published: February 2025

Abstract

Aims
This study aimed to explore relationships between visit-to-visit lipid variability, coronary artery calcification (CAC), inflammation, and long-term mortality, which may be prognostically relevant.

Methods
This prospective cohort study included participants from the Multi-Ethnic Study of Atherosclerosis with available plasma low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglycerides from all three initial exams who underwent computed tomography CAC quantification at the third (index) exam. Visit-to-visit variability (coefficient of variation) was calculated from all three initial exams. Outcomes included the index Agatston score, cardiovascular mortality, all-cause mortality, and high-sensitivity C-reactive protein (hsCRP).

Results
Altogether, 1515 participants were analysed. Higher HDL-C variability was associated with higher index Agatston score (quartile 4 [Q4; vs Q1] adjusted marginal effects 0.25 [0.02-0.48]), but not LDL-C, TC, and triglycerides variability. Over a 15.1-year median follow-up, higher HDL-C (Q4 vs Q1: adjusted sub-hazard ratio 2.68 [1.61-4.48]) and TC (Q4 vs Q1: adjusted sub-hazard ratio 2.13 [1.17-3.89]) variability, but not LDL-C and triglycerides variability, were associated with higher risk of cardiovascular mortality, which remained significant after adjusting for the index Agatston score. Additionally, higher HDL-C variability was associated with higher risk of all-cause mortality (Q4 vs Q1: adjusted hazard ratio 1.46 [1.00-2.11]), but LDL-C, TC, and triglycerides variability were not. HDL-C (Q4 vs Q1: adjusted β: 0.132 [0.034-0.230]) and TC (Q4 vs Q1: adjusted β: 0.210 [0.064-0.357]) variability, but not LDL-C and triglycerides variability, may be correlated with hsCRP.

Conclusions
Elevated HDL-C variability was associated with greater CAC burden and long-term risks of cardiovascular and all-cause mortality. These mortality-related associations were probably not completely explainable by atherosclerosis.
Regional networks in revolt: opposition to the Valois in Gascony at the end of the Hundred Years’ War, c.1452–1453
Authors: Green Andrew D M 
Published: February 2025

Abstract
This article offers a reassessment of late medieval resistance to the Valois monarchy, through examining south-western France in the mid-fifteenth century as a case study. Whereas modern scholarship has often foregrounded Valois success and treated Gascony as sliding inexorably into the maw of the French state, it is shown here that a deep-rooted revolt against King Charles VII occurred in the south-west in 1452–53, in conjunction with Gascon exiles and the English. Influential and durable networks under the leadership of regional nobles were fundamental throughout the movement, and these entities remained a potent force even after it was defeated. Overall, this is indicative of how backing for, and cooperation with, the English in France around the end of the Hundred Years’ War has traditionally been underestimated, and of how noble-led networks retained the ability to underpin and inspire resistance to the French monarchy.
Risk-stratified hepatocellular carcinoma surveillance in non-cirrhotic patients with MASLD
Authors: Mi Ke , Ye Tingdan , Zhu Lin , Pan Calvin Q 
Published: February 2025

Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly emerging as the leading global liver disorder and is poised to become the primary cause of hepatocellular carcinoma (HCC). Research indicates that nearly 50% of HCC cases in MASLD patients occur without cirrhosis, often presenting with more advanced and larger tumors. Despite this, current guidelines primarily focus on HCC screening in cirrhotic patients, with limited guidance for non-cirrhotic MASLD individuals. This narrative review seeks to identify key risk factors for HCC development, consolidate available screening methods, and propose a practical, risk-stratified algorithm for HCC surveillance in non-cirrhotic MASLD patients. We conducted a comprehensive review of studies published between 2017 and 2023 using PubMed, Embase, and CNKI, focusing on HCC risk factors and emerging screening strategies for non-cirrhotic MASLD cohorts. Key risk factors for HCC development in these patients include male sex, age over 65, hypertension, diabetes, mild alcohol consumption, smoking, dyslipidemia, elevated alanine aminotransferase levels, and a platelet count ≤ 150 × 109/L. Among the screening methods evaluated, circulating free DNA, alpha-fetoprotein (AFP) combined with protein induced by vitamin K absence or antagonist-II (PIVKA-II), and the GALAD score (incorporating Glypican-3, AFP, alpha-1-Antitrypsin, and des-gamma-carboxy prothrombin) demonstrated the highest performance. Based on these findings, we proposed a risk-stratified HCC surveillance algorithm that integrates GALAD and PIVKA-II into the existing sonography and AFP screening protocols. This review aims to provide clinicians with actionable recommendations for HCC screening in non-cirrhotic MASLD patients.
Intergenerational Coresidence with Children and Grandchildren and Maternal Sleep Duration at Mid-life
Authors: Cao Rui , Reczek Rin , Thomeer Mieke Beth 
Published: February 2025

Abstract

Objectives
Mothers with young children tend to have shorter sleep durations than childfree women, but previous research has not considered heterogeneity in sleep duration among mid-life mothers who have varying coresidential patterns with their adult, minor, and grandchildren. We examine distribution of sleep duration across mothers’ different intergenerational coresidential contexts (living without any children, living with any minor children, living with only adult children, and living with any grandchildren) and test how these patterns differ across racial/ethnic groups.

Methods
Regression analyses estimate sleep duration among a sample of mid-life mothers with minor and adult children and grandchildren from the National Longitudinal Survey of Youth 1979 (NLSY79) data (N=3,300). Moderation analyses consider differences across racial/ethnic groups (non-Hispanic White, non-Hispanic Black, Hispanic).

Results
Relative to the mothers with no coresiding children or grandchildren, mothers with coresiding minor or adult children reported less sleep. However, this gap varies across racial/ethnic groups; specifically, the lower sleep duration for mothers with coresidential children is only significant for White and Black mothers, not Hispanic mothers.

Discussion
Sleep is a critical health indicator across the life course and a contributor to other health outcomes later in life. Thus, it is important to identify whose sleep is most vulnerable—especially in mid-life when sleep trajectories are the groundwork for later-life well-being. We demonstrate the importance of coresidential status with adult and minor children and grandchildren on the sleep of mothers in mid-life, drawing specific attention to the differences across racial/ethnic groups.
The sustainability of hospital accreditation models: A cross-sectional study
Authors: Hussein Mohammed 
Published: February 2025

Abstract

Background
Despite the importance of hospital accreditation, its sustainability is jeopardised. This is due to the disparity between the rapid changes in the health sector and the accreditation standards that remain unchanged. This study aims to examine what improvements are important in enhancing the sustainability of the hospital accreditation model in Saudi Arabia.

Methods
All quality managers in accredited Saudi Arabian hospitals were invited to participate in a cross-sectional questionnaire-based study in July-August 2022. A structured questionnaire was developed, tested, piloted, and factorially validated using exploratory factor analysis. On a 5-point Likert scale, respondents were asked to rate the importance of recommended changes that are proposed to enhance the sustainability of accreditation policies, standards development, evaluation methods, and the evaluation team. The importance of the recommendations, according to the respondents, was described using the relative importance index, while multivariate linear regression was used to analyse the association with independent variables.

Results
A total of 158 valid questionnaires (64% response rate) were included in the analysis. On average, participants had 6.9 (SD 2.1) years of experience in quality management. The overall mean importance attached to improving standards development, accreditation policies, evaluation team, and evaluation methods were 3.55, 3.43, 3.41, and 3.21, on a 5-point scale, respectively. Shifting the focus of accreditation standards from structure and compliance to outcomes and improvement (mean importance=4.47), updating standards periodically to reflect current best practices and research (mean importance=4.41), and integrating consumer perspectives in all aspects of accreditation (mean importance=4.37) were the most important perceived recommendations. Multivariate regression analysis yielded that managers with more years of experience had significantly higher mean scores on the importance of improving accreditation policies (β=0.120, P =0.037), standards development (β=0.246, P &lt;0.001), evaluation methods (β=0.268, P &lt;0.001), and the evaluation team (β=0.369, P &lt;0.001).

Conclusions
Improving accreditation policies, standards development, evaluation methods, and the evaluation team are important in enhancing the sustainability of hospital accreditation programmes. This study offers insights to assist policymakers and other stakeholders in redesigning traditional accreditation models to make them more sustainable and that can supplement other performance improvement tools in improving the quality of healthcare services.
An empirical study of using radiology reports and images to improve intensive care unit mortality prediction
Authors: Lin Mingquan , Wang Song , Ding Ying , Zhao Lihui , Wang Fei , Peng Yifan 
Published: February 2025

Abstract

Objectives
The predictive intensive care unit (ICU) scoring system is crucial for predicting patient outcomes, particularly mortality. Traditional scoring systems rely mainly on structured clinical data from electronic health records, which can overlook important clinical information in narratives and images.

Materials and Methods
In this work, we build a deep learning-based survival prediction model that utilizes multimodality data for ICU mortality prediction. Four sets of features are investigated: (1) physiological measurements of Simplified Acute Physiology Score (SAPS) II, (2) common thorax diseases predefined by radiologists, (3) bidirectional encoder representations from transformers-based text representations, and (4) chest X-ray image features. The model was evaluated using the Medical Information Mart for Intensive Care IV dataset.

Results
Our model achieves an average C-index of 0.7829 (95% CI, 0.7620-0.8038), surpassing the baseline using only SAPS-II features, which had a C-index of 0.7470 (95% CI: 0.7263-0.7676). Ablation studies further demonstrate the contributions of incorporating predefined labels (2.00% improvement), text features (2.44% improvement), and image features (2.82% improvement).

Discussion and Conclusion
The deep learning model demonstrated superior performance to traditional machine learning methods under the same feature fusion setting for ICU mortality prediction. This study highlights the potential of integrating multimodal data into deep learning models to enhance the accuracy of ICU mortality prediction.
Lost Japan: Focusing on the Problems of Globalism and Nationalism in Moral Education
Authors: Sakuma Hiroyuki 
Published: February 2025

Abstract
This paper analyses, both historically and systematically, the underlying causes of specific characteristics of globalism and nationalism in Japan focusing on an ideological moral education that lies at the heart of the problems of Japanese education. The analysis highlights two issues. (1) There is no real globalism in modern Japan. Certainly, the globalization of industry, government, and academia is now loudly proclaimed in Japan. However, in the name of globalization, English education is overemphasized. (2) There is no real nationalism in modern Japan. Japan once had a nationalism centred on the emperor system from the Meiji era. However, after World War II, the emperor system in Japan was dismantled and a democratic Japanese Constitution was enacted under the influence of the Allied Powers. Furthermore, in the Basic Act on Education, the theory of ‘the perfection of personality’ based on Kant’s philosophy was transplanted. Education in post-war Japan developed based on a democratic constitution and the Basic Act on Education, which states that the purpose of education is ‘the perfection of personality’. This means that education has a strong moral flavour. Particularly at the stage of compulsory education in Japan, which is the foundation of national education, moral education is addressed through all educational activities at school. Therefore, the issues of globalism and nationalism in moral education, which this article deals with, belong directly to core problems of Japanese education.
Jack of all trades: Crosstalk between FERONIA signaling and hormone pathways
Authors: Tang Jie , Guo Hongqing 
Published: February 2025

Abstract
The receptor kinase FERONIA (FER) is a multifaceted regulator of plant growth, development, reproduction and stress responses. FER is functionally connected to many plant hormones in diverse biological processes. This review summarizes the current understanding of the interplay between FER and phytohormones, with a focus on abscisic acid, ethylene, jasmonic acid, auxin and brassinosteroid. The mutual regulation between FER and plant hormones happens at multiple levels including ligands, receptors and downstream signaling components. Plant hormones can regulate the expression of genes encoding FER and its ligands RAPID ALKALINIZATION FACTORs (RALFs) as well as the abundance and kinase activity of FER proteins. On the other hand, FER can regulate hormone biosynthesis, transport, hormone perception and downstream signaling components such as transcription factors. Evidence of the crosstalk between FER and phytohormones are also emerging in crop species. Despite the rapid progress made in this field, more mechanistic studies are still needed to gain a comprehensive understanding of the FER-phytohormone crosstalk. Future research prospects and potential approaches are also discussed in this review.
The Rise and Fall of Hardbass Flash Mobs in the European Far Right
Authors: Teitelbaum Benjamin R. 
Published: February 2025

Abstract
This chapter explores the rise of a musical flash mob genre among European radical nationalists called “hardbass.” Though regional varieties proliferate, hardbass belongs to a broader campaign among white nationalist groups globally to rebrand their cause through expressive culture as one of antiestablishment protest. Based on reviews of online social media, personal interviews, and other ethnographic data conducted among activists in Scandinavia, this chapter shows how nationalists use hardbass and its seizure of physical and sonic space to frame themselves as dissidents operating in defiance of an oppressive mainstream. Contextualizing this practice alongside contemporaneous reforms to white nationalist music making—the introduction of rap and reggae in particular—the chapter argues that the far right’s musical imagination of itself as victimized is poised to transform yet again as populist nationalist movements gain influence throughout the West.
Who Can Stop the Drums? Fiestas as Sites of Popular Organization in Venezuela
Authors: Fernandes Sujatha 
Published: February 2025

Abstract
Popular fiestas in Latin American cities have been important vehicles in contemporary imaginings of urban space and cultural identity, particularly given new geographies of racial inequality and exclusion. This chapter explores the popular fiestas celebrated in barrios in Caracas, Venezuela, as new sites for popular organizing. Following decades of social dislocation, growing crime, and the militarization of the shantytowns, residents used cultural forms as a means of taking back public spaces from the private sector and the police. After the election of leftist and mixed-race president Hugo Chávez in 1998, the barrio residents who supported him were vilified by the opposition and the media. In the religious celebrations of Cruz de Mayo and San Juan, fiesta organizers created alternative repertoires of representation, positioning themselves against middle-class civil society. This chapter examines the shifting meanings of the fiestas in a Chávez era as a form of social protest.
Iron Smithing among the Lohars of Central Peninsular India: An Ethnoarchaeological Perspective
Authors: Roy Oishi 
Published: February 2025

Abstract
This chapter deals with the indigenous iron smiths (Lohar) residing in the region of Vidarbha, Maharashtra. The methodology adopted for this study is an ethnographic survey wherein questions revolving around working methods, beliefs, customs, and rituals have been probed. This ethnoarchaeological exercise helps us to draw probable analogies for the ancient iron smithing techniques prevalent during the Early Iron Age and practiced by the Early Iron Age Megalithic community residing in the region of Vidarbha, Maharashtra. The chapter details how iron smiths in this community produce tools such as the adze, the ax, and the nail parer. It also describes the iron smithing workshop and forging techniques adopted by the present day Lohar community. We do find artefactual evidence from archaeological context pointing towards iron smelting and iron smithery activity; however, we find difficulties in interpreting these finds. The chapter gives us an insight to the importance of ethnographic and experimental studies in interpreting the archaeological finds and postulate probable technological know-how and the cognition abilities of the Early Iron Age community.
Psycholinguistic Studies in Dravidian Languages
Authors: Narasimhan Bhuvana , Kurian Matthew Annu 
Published: February 2025

Abstract
The field of psycholinguistics aims to discover the psychological mechanisms that enable people to acquire, comprehend, and produce any human language. Speakers of different languages face different acquisition and processing challenges because languages can vary considerably in their vocabulary, meanings, sound and grammatical structures, and patterns of language use. Therefore, psycholinguistic theory must be founded on empirical research investigating typologically and genetically diverse languages. The chapter provides a survey of language acquisition and processing research conducted in Dravidian languages with the aim of highlighting the range of research that has been conducted in these languages and indicating possible lines of future inquiry.
Havana’s Living Dead
Authors: Hester Jennessa 
Published: February 2025

Abstract
Alejandro Brugués’s Juan of the Dead (2011) is often considered the origin point of Cuban horror film. This chapter challenges this myth, arguing instead that while horror movies existed in Cuba before the 2000s, they were omitted from the generic canon by white imperializing forces. This process, termed curatorial colonization, resulted in the erasure of Afro-Cuban subjection as constitutive of actual terror, rendering invisible a Black horror tradition within the nation. Through a re-curation of one such colonized film, Tomás Gutiérrez Alea’s The Last Supper (1976), this chapter details how the horror genre and its fans have unassumingly swept away narratives of Black marginalization and terror. To re-curate Cuban cinema so that it includes Black terror is to proclaim to the world that it is not just those fictional zombies that matter, but also the corpses of atrocity and enslavement.