bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Tibetan Plateau vertical heating on the Asian summer monsoon on the interdecadal scale
Authors: Yu Liwei , Si Dong , Shen Xinyong , Lang Xianmei , Zhang Ran , Li Qingquan 
Published: October 2022

AbstractThis study investigated the impacts of Tibetan Plateau vertical heating (TPVH) on the Asian summer monsoon (ASM) on the interdecadal scale since the beginning of the 20th century. The ASM, corresponding to TPVH, generally enhances on the interdecadal scale. In the upper troposphere, the upper‐level westerly and easterly jet streams shift northwards in Asia, with two meridional “southern low and northern high” wave‐like patterns dominating in East Asia and India, respectively. In the lower troposphere, the summer monsoonal airflow and convergence zone migrate northwards in Asia, and two meridional “southern high and northern low” patterns appear in East Asia and India, respectively. Thus, TPVH can strengthen the baroclinicity over northern East Asia and northern India, but weaken it over southern East Asia and southern India. Moreover, two anomalous meridional circulation cells are identified in East Asia and India, with ascending branches in their northern parts and descending branches in their southern parts. Eventually, the ASM strengthens, leading to a southern dry and northern wet pattern in East Asia and India.
Does the gender matter?: Anxiety symptoms and emotion dysregulation in adults with autism and intellectual disabilities
Authors: Sáez‐Suanes Gema P. , García‐Villamisar Domingo , Pozo Armentia Araceli del 
Published: October 2022

AbstractResearch shows high rates of anxious symptoms in people autistic spectrum disorder (ASD). Finding factors related to the development of anxiety in ASD is necessary. Emotion regulation (ER) is associated with anxiety in ASD. Moreover, some studies find higher rates of anxiety in women with ASD. A total of 121 adults (M = 35.46 years, SD = 9.46) with ASD and intellectual disabilities were evaluated to verify moderating role of gender and mediating role of ER. A moderated mediation analysis supported the moderated role of gender in the relationship mediated by emotional dysregulation between ASD and anxiety. These findings suggest that interventions designed to prevent or reduce anxiety symptoms in women with ASD should include among their goals emotional regulation.Lay SummaryIf we want to reduce or prevent anxiety symptoms in women with ASD we must work on emotional regulation.
Apple pomace management by anaerobic digestion and composting: a life cycle assessment
Authors: Ampese Larissa Castro , Ziero Henrique Di Domenico , Velásquez Jean , Sganzerla William Gustavo , Martins Gilberto , Forster‐Carneiro Tânia 
Published: October 2022

AbstractThe food industry generates large volumes of organic by‐products, which require proper environmentally friendly disposal. In the case of the apple‐processing industry, apple pomace constitutes 25–30% of the original apple weight. The conventional treatment of food industry by‐products involves composting, which releases greenhouse gases and contributes to climate change. This study presents an environmental assessment of apple pomace management technologies for industrial juice processing. The life cycle analysis (LCA) methodology was applied as a tool for evaluating the technological routes of composting (method conventionally used) and anaerobic digestion (AD) (an innovative technological route). The main change proposed to the current process would be the implementation of anaerobic reactors in the apple industry, avoiding the transport of apple pomace to the composting unit and producing bioenergy from the burning of methane‐rich biogas. The results showed a reduction in the environmental impacts in the system composed of AD of apple pomace. In the categories related to eutrophication and acidification, a reduction of approximately 50% was obtained when comparing AD with composting. The global warming potential and greenhouse gas emissions showed a significant reduction with the adoption of AD, due to the conversion of biogas into energy and its use by the industry. In conclusion, the implementation of AD technology for the management of apple pomace can be a promising alternative to recover bioenergy and decrease the environmental impacts caused by the apple‐juice processing industry. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.
Biorefinery concepts in the transition to the bioeconomy: A Q‐analysis from the Brazilian experts’ perspectives
Authors: Conteratto Caroline , Artuzo Felipe Dalzotto , Santos Omar Inácio Benedetti , Talamini Edson 
Published: October 2022

AbstractBioeconomy development requires the adoption of a comprehensive concept of biorefinery. This study analyzes the experts’ perceptions regarding biorefinery concepts and discusses the implications for development of the bioeconomy in Brazil. Forty‐five statements about biorefinery concepts were prepared. Statements were grouped accordingly to assess whether the experts agree more with a conventional, transitional or comprehensive biorefinery concept. The statements were organized and submitted to the experts following the procedures outlined by Q‐methodology. Thirty‐six experts from the government (13), academia (17) and industry (6) participated in the study. Government, academic and industry experts answered ‘what is a biorefinery?’ differently. Biorefinery as a biobased value chain, a bioecological economic model and the basis for sustainable energy production were the most relevant among the eight factors explaining the experts’ perspectives on biorefinery (63.35% of the total variation). Since the perspectives on biorefinery vary among experts from different sectors, we conclude that joint efforts should be made to adopt a comprehensive biorefinery concept to enhance the transition to the bioeconomy. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.
The protective effects of nesfatin‐1 in neurological dysfunction after spinal cord injury by inhibiting neuroinflammation
Authors: Jin Xin , Guan Kai , Chen Zhengyu , Sun Yongwei , Huo Hongjun , Wang Jinle , Dong Huihui 
Published: October 2022

AbstractAimsSpinal cord injury (SCI) is one of the most severe neurological diseases. However, there is still no effective treatment for it. Nesfatin, a precursor neuropeptide derived from nucleobindin 2 (NUCB2), has displayed a wide range of protective effects in different types of cells and tissue. However, the effects of nesfatin‐1 in SCI have not been reported before.Materials and methodsA SCI model was established. The behavior of mice was assessed using the Basso, Beattie, and Bresnahan (BBB) assessment.ResultsHere, we report that the administration of nesfatin‐1 improved neurological recovery in SCI mice by increasing BBB scores, reducing lesion area volume and spinal cord water content. Also, nesfatin‐1 ameliorated oxidative stress by reducing reactive oxygen species (ROS) levels and increasing superoxide dismutase (SOD) activity. We also found that nesfatin‐1 prevented neuronal apoptosis in SCI mice by reducing caspase 3 activity and the expression of Bax, as well as increasing B‐cell lymphoma‐2 (Bcl‐2). Additionally, nesfatin‐1 reduced the levels of interleukin 6 (IL‐6), interleukin‐1β (IL‐1β), and tumor necrosis factor‐α (TNF‐α). Nesfatin‐1 also promoted microglia towards M2 polarization by increasing the marker CD206 but reducing CD16. Importantly, nesfatin‐1 enhanced the phosphorylation of signal transducer and activator of transcription 1 (STAT1) but reduced the expression levels of toll‐like receptor 4 (TLR4) and phosphorylated nuclear factor kappa‐B p65 (p‐NF‐κB p65).ConclusionOur findings imply that nesfatin‐1 exerts neuroprotective actions in SCI by promoting the activation of M2 microglia, and its underlying mechanisms might be related to the activation of STAT1 and inhibition of the TLR4/NF‐κB signaling pathway.
An integrated view of eco‐innovation in the service sector: Dynamic capability, cooperation and corporate environmentalism
Authors: Arranz Nieves , Arroyabe Marta F. , Li Jun , Arranz Carlos F. A. , Fernandez de Arroyabe Juan Carlos 
Published: October 2022

AbstractThis study integrates the insights of the dynamic capabilities theory with the perspective of strategic orientations to provide an integrated view of eco‐innovation in service organizations. We empirically test this integrated view of eco‐innovation in the case of Spain with a sample of 3192 service firms from the Spanish Technological Innovation Panel from 2012 and 2015. Our results allow the verification of the properties of persistence, complementarity and dependence on resources for eco‐innovation, thus being able to conceptualize it as an innovation capability. Moreover, we support that both eco‐innovation and cooperation, once set in motion, could reinforce each other, suggesting that the relationship between cooperation and eco‐innovation is complementary and sequential. We also argue that the strength of strategic orientations, particularly corporate environmentalism, will spur service firms to integrate and adapt capabilities to undertake more cooperative innovation in order to deliver outcomes in tandem with their strategic objectives.
Three‐dimensional cardiac computed tomography compared with autopsied material for the assessment of the mitral valve
Authors: Krawczyk‐Ożóg Agata , Hołda Mateusz K. , Batko Jakub , Bartuś Stanisław , Rajtar‐Salwa Renata 
Published: October 2022

AbstractTo compare the morphometrical features of non‐diseased mitral valves imaged in three‐dimensional (3D) cardiac computed tomography with those analyzed macroscopically in autopsied healthy human hearts. A total of 51 cardiac computed tomography scans and 120 adult autopsied human hearts without cardiovascular disease were examined. The 3D reconstruction and visualization software (Mimics Innovation Suite 22, Materialise) was used for heart chambers semi‐automatic segmentation and myocardial manual segmentation to visualize a 3D structure of the mitral valve complex and to perform all measurements. Direct comparison of corresponding mitral valve parameters revealed significant differences between obtained results. Significantly larger intercommisural diameter, aorto‐mural diameter, and perimeter of the mitral annulus were observed in tomographic scans (all p < 0.0001). However, the intercommissural/aorto‐mural diameter ratio showed comparable values for both groups. Nevertheless, the size of anterior mitral leaflet was higher in autopsied material. The height of the P2 scallops was the only parameter that show no significant difference between two groups (p = 0.3). The use of 3D postprocessing algorithms provides a very accurate image of the mitral valve structure, which could be useful for the precise non‐invasive assessment of mitral valve size and structure. Three‐dimensional contrast enhanced cardiac computed tomography significantly overestimates the measurements of the mitral annulus compared to postmortem analysis.
Correlation between individual physical characteristics and spinal cerebrospinal fluid volume
Authors: Liu Hu , Zhou Hong‐Mei , Wu Xin‐Wei , Zhou Qing‐He 
Published: October 2022

AbstractSpinal cerebrospinal fluid (CSF) volume is the primary determinant for the spread of spinal anesthesia. However, it cannot generally be obtained during spinal anesthesia, and patient physical characteristics are always adopted to obtain a suitable spinal spread. In this study, we sought to explore the relationship between individual physical characteristics and thoracosacral CSF volume to provide a theoretical basis for more accurate spinal anesthesia. In total 35 healthy volunteers were enrolled in this study. Three‐dimensional magnetic resonance imaging was used to reconstruct and measure the spinal CSF volume. Physical characteristics and spinal CSF volume were recorded. Bivariate and multiple linear regression analyses were used to analyze the correlation between the individual physical characteristics and thoracosacral CSF volume. Total of 31 participants were included in the final analysis. Bivariate linear correlation analysis showed that the volume of thoracosacral CSF was correlated with both individual dorso‐sacral distance and height (both p < 0.01), but not with abdominal girth (p > 0.05). Multiple linear regression analyses revealed that the adjusted R2 values were 0.404 for the regression equation between thoracosacral CSF volume, dorso‐sacral distance, and abdominal girth. Our study showed that dorso‐sacral distance and abdominal girth were essential factors contributing to thoracosacral CSF volume. A longer dorso‐sacral distance and smaller abdominal girth mean larger spinal CSF volume.
The anatomical growth of the thoracic cage in adolescents with specific reference to axial growth comparing the right and left hemithorax
Authors: Archer James E. , Dong Huan , Berryman Fiona , Pynsent Paul , Gardner Adrian 
Published: October 2022

AbstractThis study has demonstrated the changing volume of both the anterior and posterior thorax in normal adolescents (without spinal or thoracic deformity), differentiating for both sex and age, to further understand how the thorax grows, along with the differences in growth between the anterior and posterior thorax. The thorax was measured on axial CT slices at every vertebral level from T3 to T12 in a series of scans previous taken for routine clinical care. Measurements taken were the anteroposterior thoracic distance and the area of the anterior and posterior rib prominences on either side of the thorax. Data was analyzed per vertebral level, differentiating for age and sex. There were 486 CT scans analyzed (257 males and 229 females) between the ages of 8 and 18 years. The analysis identified that for the anterior thorax, there are three phases of growth with an initial slow increase in volume, followed by a stabilization of little growth, followed by another phase of a more rapid increase in volume. For the posterior thorax, there was a gradual increase in area with increasing age. This study demonstrates that the shape of the thorax is age and sex dependent, with males having both a greater width and depth of thorax compared to females. Of particular note is the difference in patterns of growth between the anterior and posterior thorax. This information will add to the understanding of normal growth, which will aid in the management of conditions where that growth is disturbed.
Front‐line treatment efficacy and clinical outcomes of elderly patients with multiple myeloma in a real‐world setting: A multicenter retrospective study in China
Authors: Bao Li , Liu Ai‐Jun , Chu Bin , Wang Qian , Dong Yu‐Jun , Lu Min‐Qiu , Shi Lei , Gao Shan , Wang Yu‐Tong , Wang Li‐Fang , Chen Wen‐Ming , Zhuang Jun‐Ling 
Published: October 2022

AbstractBackgroundThe use of proteasome inhibitors (PIs), new immune modulators (IMiDs), and other new drugs, as well as high‐dose chemotherapy combined with autologous stem cell transplantation has considerably improved the survival of young patients with multiple myeloma (MM). However, the improvement in survival among elderly patients remains insufficient. Optimal treatment recommendation models for elderly patients with MM have not been developed especially there are quite few study in the real world.MethodsWe retrospectively analyzed the treatment patterns and outcomes of 328 Chinese patients (≥65 years) with MM in a real‐world setting. Patients were divided into three groups according to induction regimens.ResultsThe median age of the cohort was 70 (65–86) years. The patients were divided into group 1 (PIs based regimens, n = 218), group 2 (IMiDs based regimens, n = 48) and group 3 (PIs + IMiDs, n = 62). Induction regimens in group 3 produced higher overall response rate than group 1 and 2 (85.42% vs. 71.08% vs. 66.67%, p = 0.016). The median follow‐up of the cohort was 30 (interquartile range [IQR] 18–36) months. For the entire cohort median progression‐free survival (PFS) was 26 (IQR 12.00–42.89) months and overall survival (OS) was 60 (IQR 40.00–67.20) months. The PFS were not significantly different among the three groups (28 months vs. 18 months vs. 26 months, p = 0.182). So were the OS (60 months vs. 59 months vs. not reached, p = 0.067). Multivariate analysis revealed that age >70 year, frailty status (Geriatric vulnerability score), induction efficacy < partial remission, and no maintenance treatment were independent poor prognostic factors for OS.ConclusionFront‐line induction regimens combining PIs and IMiDs developed more deep response than single PI or IMiD based regimens. Maintenance treatment can further improve the clinical outcome in elderly MM patients in real‐world setting.
Cost‐effectiveness analysis of pembrolizumab plus chemotherapy versus chemotherapy as the first‐line treatment for advanced esophageal cancer
Authors: Ye Zhuo‐Miao , Xu Zhe , Wang Hao‐Lun , Wang Ying‐Yuan , Chen Ze‐Chang , Zhou Qin , Li Xiang‐Ping , Zhang Ying‐Ying 
Published: October 2022

AbstractObjectiveThe KEYNOTE‐590 trial showed that individuals with advanced esophageal cancer who received Pembrolizumab in combination with chemotherapy as a first‐line regimen achieved a significant extension of survival. However, this treatment option increases the financial burden on patients and the economic benefits remain to be further evaluated.MethodsA Markov model was used to simulate 10‐year survival of patients with esophageal cancer from the perspective of United States (US) Medicare payers. We evaluated the economics of Pembrolizumab plus chemotherapy in the PD‐L1 positive score (CPS ≥10) and any PD‐L1 expression groups, respectively. We estimated total costs, quality‐adjusted life years (QALYs), and calculated incremental cost effectiveness ratios (ICERs). Sensitivity analyses were conducted to explore the impact of uncertainties on the results. Subgroup analysis was also performed.ResultsThe analysis results showed that the ICER for pembrolizumab plus chemotherapy versus chemotherapy alone was $293,513.17/QALYs in the any PD‐L1 expression group. This exceeded the threshold of willingness to pay ($150,000/QALYs). ICERs were most sensitive to the cost of pembrolizumab and the ICERs exceeded $150,000/QALYs in all subgroups.ConclusionsEvidence suggests that first‐line pembrolizumab in combination with chemotherapy is not a cost‐effective option for advanced esophageal cancer in the US, regardless of PD‐L1 expression status.
Immunotherapy combined with chemotherapy improved clinical outcomes over bevacizumab combined with chemotherapy as first‐line therapy in adenocarcinoma patients
Authors: Wang Min , Li Ji , Xu Shuhui , Li Yuying , Li Jiatong , Yu Jinming , Tang Xiaoyong , Zhu Hui 
Published: October 2022

AbstractPurposeNo definite conclusion has yet to be reached for the first‐line treatment combined with chemotherapy for advanced adenocarcinoma NSCLC patients with negative driver genes. This study sought to compare the clinical outcomes of Beva+ChT and IO+ChT as first‐line treatment for this population and investigated whether the statuses of BM, PD‐L1 expression, and KRAS and TP53 mutations could influence the results.Patients and methodsThe clinical data of patients with adenocarcinoma NSCLC who received first‐line therapy were retrospectively collected and the patients were assigned to the IO+ChT and Beva+ChT groups. The disease control rate (DCR), progression‐free survival (PFS), and overall survival (OS) were evaluated between the two groups. The survival effects of BM, PD‐L1 expression, and KRAS and TP53 mutations were also evaluated.ResultsFrom April 2018 to October 2020, a total of 105 patients with first‐line therapy were included in our analysis; 54 (51.4%) patients were included in the IO+ChT group and 51 (48.6%) patients were included in the Beva+ChT group. The results showed that OS (NR vs. 18.3 m, p = 0.011) and PFS (14.9 m vs. 6.3 m, p < 0.001) were superior in patients in the IO+ChT group than in patients in the Beva+ChT group. Further analysis revealed that the OS (median OS: NR vs. 14.7 months, p = 0.039) and PFS (median PFS: 18.5 vs. 5.5 months, p < 0.001) advantages of the IO+ChT group were also seen in the PD‐L1 > 1% subgroup but were not seen in the PD‐L1 < 1%, BM or KRAS mutation subgroups.ConclusionsICIs combined with ChT improved clinical outcomes over Beva combined with ChT as first‐line therapy for adenocarcinoma patients without driver gene alterations, especially in patients with PD‐L1 ≥ 1%.
Integrated tumor genomic and immune microenvironment analysis identifies predictive biomarkers associated with the efficacy of neoadjuvant therapy for triple‐negative breast cancer
Authors: Zhu Yanhui , Zhang Hongfei , Pan Chaohu , He Gao , Cui Xiaoli , Yu Xiafei , Zhang Xiaoqiang , Wu Dongfang , Yang Junzhe , Wu Xian , Luo Haitao , Liu Xiaoan 
Published: October 2022

AbstractBackgroundAlthough neoadjuvant chemotherapy (NAC) is currently the best therapy for triple‐negative breast cancer (TNBC), resistance still occurs in a considerable proportion, thus it is crucial to understand resistance mechanisms and identify predictive biomarkers for patients selection.MethodsBiopsy samples were collected from 21 patients with TNBC who underwent NAC. Whole‐exome sequencing (WES), targeted sequencing, and multiplex immunohistochemistry (mIHC) were carried out on the clinical samples and used to identify and validate potential biomarkers associated with response to NAC. In addition, data on 190 TNBC patients who had undergone chemotherapy were obtained from The Cancer Genome Atlas (TCGA) and analyzed to further validate our findings.ResultsBoth the tumor mutational burden (TMB) and tumor neoantigen burden (TNB) were significantly higher in responders than in non‐responders. Higher response rates and longer survival rates were observed in patients with higher TMB. Patients with higher ratios of CD8 to M2 macrophages had higher response rates and improved survival rates. Finally, the integrated analysis demonstrated that the combination of TMB and the ratio of CD8 T cells to M2 macrophages could further distinguish patients who benefitted from the treatment in both enrolled patients and public data.ConclusionsThe findings of this study indicated that the combination of TMB and the ratio of CD8 T cells to M2 macrophages may be a potential biomarker for improving the recognition of NAC responders, thereby providing a basis for developing precision NAC regimens.
Mycobacterium iranicum pulmonary disease in an elderly patient with extensive usual interstitial pneumonia: Case report
Authors: Kalra Salil , Rubinstein Israel 
Published: October 2022

AbstractWe report the first case of Mycobacterium iranicum pulmonary disease in an elderly patient with extensive usual interstitial pneumonia and traction bronchiectasis. He was treated with oral doxycycline, ciprofloxacin, and sulfamethoxazole/trimethoprim daily for 9 months. This was associated with eradication of the microorganism in the sputum and steady weight gain.
Lipschütz's ulcers in an adolescent with SARS‐CoV2 infection
Authors: Morais Mariana Lira , Moura Mário , Moreira Ana 
Published: October 2022

AbstractLipschütz's ulcers (LU) are rare entities, which occur mostly in nonsexually active young women. LU appears to be associated with infectious conditions such as Epstein‐Barr virus or cytomegalovirus. We report a case that revealed that SARS‐CoV‐2 infection could be considered a trigger event for the appearance of acute vulvar ulceration.