bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns and predictors of site‐specific recurrence in cervical cancer after radical hysterectomy
Authors: Kato Tatsuya , Shimada Chisa , Kato Fumi , Okada‐Kanno Hiromi , Takeda Mahito , Endo Daisuke , Ihira Kei , Mitamura Takashi , Konno Yosuke , Sakuragi Noriaki , Watari Hidemichi 
Published: September 2022

AbstractAimThis study examines patterns and predictors of site‐specific recurrence to explore the causes of local recurrence of cervical cancer.MethodsRadical hysterectomy was performed in 121 patients (stage IB–IIB). Nerve‐sparing was performed whenever possible. The first recurrence in local, regional, and distant areas was examined. We investigated the possibility of nerve involvement in local recurrence, focusing on paravaginal tissues containing the pelvic plexus. We provide Supporting Information on local recurrence in the paravaginal area.ResultsLocal recurrence was an independent event from regional or distant recurrence. Local recurrence was seen only in high‐risk patients, while regional and distant recurrences were not or less related to the risk category. The independent risk factors by logistic regression for local, regional, and distant recurrence were parametrial invasion, vaginal invasion, and lymph node metastasis, respectively. Local recurrence showed a comparable or more significant negative impact on survival than distant recurrence. Among seven patients with local recurrences, five had a recurrence in the paravagina. The rate of paravaginal recurrence was one in 76 early‐stage and four in 45 locally advanced diseases. Four sites of paravaginal recurrence occurred on the nerve‐sparing side and two on the non‐nerve‐sparing side. Supporting Information demonstrated histological evidence of perineural spread into the pelvic plexus and perineural invasion of the primary tumor.ConclusionsA high percentage of local recurrences are in paravaginal tissue containing the pelvic plexus. The causal association of nerve‐sparing surgery and perineural invasion with local recurrence needs to be investigated in large prospective studies.
LncRNA LAMTOR5‐AS1 sponges miR‐210‐3p and regulates cervical cancer progression
Authors: Yang Bo , Wang Ziyi , Deng Yuping , Xiao Lingzhi , Zhang Keqiang 
Published: September 2022

AbstractAimCervical cancer has attracted increasing attention in recent years, and the incidence has shown a trend of younger age. Therefore, it is an effective method to regulate the progression of cervical cancer through new prognostic biomarkers. The purpose of this study was to evaluate the potential of lncRNA LAMTOR5‐AS1 (LAMTOR5‐AS1) as a prognostic biomarker and reveal its regulatory role in cervical cancer.MethodsA total of 120 patients with cervical cancer were selected as research subjects to verify the prognostic effect of LAMTOR5‐AS1 in a series of experiments. The expression of LAMTOR5‐AS1 in cervical cancer tissues and cells was determined by polymerase chain reaction assay. The proliferation, migration, and invasion ability of cervical cancer cells were evaluated by Cell Counting Kit‐8 (CCK‐8) and Transwell assay. Luciferase reporter gene detection was used to determine the mechanism of LAMTOR5‐AS1 targeting miR‐210‐3p, and to reflect the prognostic value of LAMTOR5‐AS1 according to statistical methods.ResultsLAMTOR5‐AS1 decreased in cervical cancer tissues, while miR‐210‐3p expression increased. In the study of cervical cancer cells, it was found that the LAMTOR5‐AS1 sponge miR‐210‐3p was associated with the malignant progression of cervical cancer. Overexpression of LAMTOR5‐AS1 could effectively inhibit the development of cervical cancer cells and might be chosen as a prognostic biomarker of cervical cancer.ConclusionsLAMTOR5‐AS1 sponges miR‐210‐3p and modulates the progression of cervical cancer, which predict the prognosis of cervical cancer patients.
Safety ofCOVID‐19 vaccines in children with inborn errors of metabolism in terms of developing metabolic decompensation
Authors: Zubarioglu Tanyel , Oral‐Cebeci Sinem , Hopurcuoglu Duhan , Uygur Esma , Ahmadzada Saffa , Uzunyayla‐Inci Gözde , Oge‐Enver Ece , Akca Sedanur , Aghalarov Mirsaid , Yilmaz Gizem , Kiykim Ertugrul , Aktuglu‐Zeybek Cigdem 
Published: September 2022

AimThere are no recommended guidelines or clinical studies on safety of COVID‐19 vaccines in patients with inborn errors of metabolism (IEMs). Here, we aimed to examine the relationship between COVID‐19 vaccination and metabolic outcome in paediatric IEM patients.MethodsPatients with IEM between the ages of 12 and 18 were enrolled. Term metabolic decompensation was defined as acute disruption in metabolic homeostasis due to vaccination. Clinical and biochemical markers were compared between pre‐ and post‐vaccination periods.ResultsData from a total of 36 vaccination episodes in 18 patients were included. Thirteen patients had intoxication‐type metabolic disorders including organic acidemia (OA), urea cycle disorders (UCDs), maple syrup urine disease (MSUD) and phenylketonuria (PKU); 4 patients had energy metabolism disorders including fatty acid metabolism disorders and LIPIN 1 deficiency; and 1 patient had glycogen storage disorder (GSD) type 5. Seventeen patients received BNT162b2, and 1 received CoronaVac because of an underlying long QT syndrome. Fatty acid metabolism disorders, LIPIN 1 deficiency and GSD type 5 were included in the same group named ‘metabolic myopathies’. In two PKU patients, plasma phenylalanine level increased significantly within 24 h following the second dose of vaccination. None of the OA, UCD, MSUD and metabolic myopathy patients experienced acute metabolic attack and had emergency department admission due to metabolic decompensation within 1 month after vaccination.ConclusionsCOVID‐19 vaccines did not cause acute metabolic decompensation in a cohort of 18 children with IEM.
Municipal bond sectoral risk and information intermediation in uncertain times: Evidence from the Covid‐19 pandemic
Authors: Yang Lang (Kate) , Winecoff Ruth 
Published: September 2022

AbstractThe municipal bond market is not homogeneous but consists of varying credits supporting different governmental activities. In this paper we discuss how sectors form and how they are differentially subject to market risks, using the Covid‐19 pandemic as a case study. The pandemic has disrupted all financial markets, particularly some municipal bond sectors supported by nongeneral obligation credits, such as health care, arts, and transportation. By comparing the sectors that face a greater increase in risk with others, we empirically examine the market uncertainty hypothesis that intermediation provides stronger certification value when sectoral risk increases. We find an increased use of insurance among high‐risk‐elevation bonds. Bond insurance, nevertheless, is not associated with larger reductions in offering yields in the high‐risk‐elevation sectors on average, but only for issuers consistently insuring all issuances. The yield difference between unrated and rated bonds expands more in the high‐risk‐elevation sectors; for an average unrated bond in such sectors, receiving any investment‐grade rating is associated with yield reductions.
Impacts of iron on phosphate starvation‐induced root hair growth in Arabidopsis
Authors: Xue Caiwen , Li Wenfeng , Shen Renfang , Lan Ping 
Published: September 2022

AbstractIn Arabidopsis, phosphate starvation (‐Pi)‐induced responses of primary root and lateral root growth are documented to be correlated with ambient iron (Fe) status. However, whether and how Fe participates in ‐Pi‐induced root hair growth (RHG) remains unclear. Here, responses of RHG to different Fe concentrations under Pi sufficiency/deficiency were verified. Generally, distinct dosage effects of Fe on RHG appeared at both Pi levels, due to the generation of reactive oxygen species. Following analyses using auxin mutants and the phr1 mutant revealed that auxin and the central regulator PHR1 are required for Fe‐triggered RHG under −Pi. A further proteomic study indicated that processes of vesicle trafficking and auxin synthesis and transport were affected by Fe under −Pi, which were subsequently validated by using a vesicle trafficking inhibitor, brefeldin A, and an auxin reporter, R2D2. Moreover, vesicle trafficking‐mediated recycling of PIN2, an auxin efflux transporter, was notably affected by Fe under ‐Pi. Correspondingly, root hairs of pin2 mutant displayed attenuated responses to Fe under ‐Pi. Together, we propose that Fe affects auxin signalling probably by modulating vesicle trafficking, chiefly the PIN2 recycling, which might work jointly with PHR1 on modulating ‐Pi‐induced RHG.
Temporal dynamics of emotional processing: Parsing trial‐wise variance of the late positive potential using Generalizability Theory
Authors: Hill Kaylin E. , Haney Alison M. , Foti Dan , Aslinger Elizabeth , Thomas Katherine M. , Lane Sean P. 
Published: September 2022

AbstractThe reliability of individual trial event‐related potential (ERP) components extracted from electroencephalogram has been consistently questioned since ERP research began. This ambivalence is based on misunderstood assumptions stemming from Cronbach and Classical Test Theory. Contemporary methods allow for the reliability of individual ERP trials to be estimated and for analyses of these trial‐level ERP components to be meaningfully parsed. We illustrate the use of Generalizability Theory procedures in estimating the reliability of trial‐level ERPs using the late positive potential (LPP), a neural measure of motivated attention toward emotionally evocative stimuli. Individuals (N = 88) completed a passive viewing task while continuous EEG was recorded. Variability in trial‐level LPP responses was decomposed into facets corresponding to individual differences, chronological trial within block, stimulus type, their two‐way interactions, and specific stimuli. We estimated various reliability coefficients and found that both overall and category‐specific person‐level LPP estimates have good‐to‐excellent reliability, while the reliability of within‐person differences (i.e., change) between arousal categories was fair for the early LPP. These results were generally consistent across time windows, but were highest early in the LPP time course. We argue that investigating reliability using trial‐level data allows researchers to pursue hypotheses focused on neurophysiological dynamics that unfold over the course of an experiment and not risk false inferences (i.e., ecological fallacy) when using person‐level aggregates to deduce such processes. Moreover, such analyses provide information that allows researchers to optimize their protocols by potentially reducing the number of individual trials, burden on participants, and cost, while retaining sufficient reliability.
A Novel Patient-Specific Computational Fluid Dynamics Study of the Activation of Primary Collateral Pathways in the Circle of Willis During Vasospasm
Authors: Straccia Angela , Chassagne Fanette , Bass David I. , Barros Guilherme , Leotta Daniel F. , Sheehan Florence , Sharma Deepak , Levitt Michael R. , Aliseda Alberto 
Published: September 2022

Abstract
The Circle of Willis (CoW) is a redundant network of blood vessels that perfuses the brain. The ringlike anatomy mitigates the negative effects of stroke by activating collateral pathways that help maintain physiological perfusion. Previous studies have investigated the activation of these pathways during embolic stroke and internal carotid artery occlusion. However, the role of collateral pathways during cerebral vasospasm—an involuntary constriction of blood vessels after subarachnoid hemorrhage—is not well-documented. This study presents a novel technique to create patient-specific computational fluid dynamics (CFD) simulations of the Circle of Willis before and during vasospasm. Computed tomographic angiography (CTA) scans are segmented to model the vasculature, and transcranial Doppler ultrasound (TCD) measurements of blood flow velocity are applied as boundary conditions. Bayesian analysis leverages information about the uncertainty in the measurements of vessel diameters and velocities to find an optimized parameter set that satisfies mass conservation and that is applied in the final simulation. With this optimized parameter set, the diameters, velocities, and flow rates fall within typical literature values. Virtual angiograms modeled using passive scalar transport agree closely with clinical angiography. A sensitivity analysis quantifies the changes in collateral flow rates with respect to changes in the inlet and outlet flow rates. This analysis can be applied in the future to a cohort of patients to investigate the relationship between the locations and severities of vasospasm, the patient-to-patient anatomical variability in the Circle of Willis, and the activation of collateral pathways.
Stagnation Point Heat Transfer to an Axisymmetric Impinging Jet at Transition to Turbulence
Authors: Antošová Zuzana , Trávníček Zdeněk 
Published: September 2022

Abstract
A round air jet issuing from a long straight pipe and impinging perpendicularly onto a heated flat plate was investigated experimentally. The Reynolds number (Re) covered the fully laminar, transitional, and fully turbulent regimes—Re = 850–15,400. The main focus of this investigation was the transition regime, which occurred at Re = 2250–3010. Various measurements were recorded during the experiments using a hot-wire anemometer, an infrared thermometer, and a thermopile heat flux sensor; the mass transfer was measured using the naphthalene sublimation technique. The stagnation point heat transfer was correlated to the laminar and turbulent regimes in the form of the stagnation point Nusselt number, Nu0 = CRemPr0.4, where the exponent m = 0.50 and 0.55, respectively. The Nu0–Re relationship exhibited nonmonotonic behavior (decrease) in the transition regime. Two counteracting mechanisms occur during transition—jet core shortening and an increase in velocity fluctuation; the former reduces Nu0, whereas the latter increases it.
Design Under Uncertainties of the Thermal Ablation Treatment of Skin Cancer
Authors: Ferreira Luiz Fernando Silva , Bermeo Varon Leonardo Antonio , Orlande Helcio Rangel Barreto , Lamien Bernard 
Published: September 2022

Abstract
This computational work deals with the optimal design of the thermal ablation treatment of skin cancer, by considering uncertainties in the model parameters. The tumor and other tissues were heated by a laser. Nanoparticles were used to improve the effects of the heating procedure and to promote thermal damage localized in the region containing the tumor. Treatment protocols examined in this work involved one single heating session with different prespecified durations, where the design variables were considered as the volume fraction of nanoparticles in the epidermis and tumor, as well as the time variation of the incident laser fluence rate. The optimal design problems were solved with the Markov Chain Monte Carlo method, by applying a modified version of the Metropolis-Hastings algorithm with sampling by blocks of parameters. The two parameter blocks were given by the properties of the tissues and by the design variables. The prior for the volume fraction of nanoparticles was given by a truncated Gaussian distribution, while a noninformative Gaussian Markov random field prior was used for the time variation of the laser fluence rate. The posterior distributions of the design variables were estimated by taking into account uncertainties in the model parameters and the desired statistical distribution of the thermal damage in the region of interest. The stochastic simulations resulted in optimal thermal damages with small uncertainties, which closely followed their desired statistical distribution functions.
A Study on Fundamental Combustion Properties of Trimethyl Orthoformate: Experiments and Modeling
Authors: Ngũgĩ John Mbũrũ , Richter Sandra , Braun-Unkhoff Marina , Naumann Clemens , Riedel Uwe 
Published: September 2022

Abstract
Trimethyl orthoformate (TMOF: HC(OCH3)3) has recently been examined as a viable biofuel. TMOF is a branched isomer of oxymethylene ether-2 (OME2) that, due to its high oxygen content and lack of direct carbon-carbon bonds, considerably reduces the formation of soot particles. To meet the challenges of a more flexible and sustainable power generation, a detailed understanding of its combustion properties is essential for its safe and efficient utilization, neat or in blends. In this work, two fundamental combustion properties of TMOF were studied: (i) Auto-ignition of TMOF/synthetic air mixtures (φ = 1.0; diluted 1:5 with N2) using the shock tube method at pressures of 1, 4, and 16 bar, and (ii) Laminar burning velocities of TMOF/air mixtures using the cone angle method at ambient and elevated pressures of 3 and 6 bar. Furthermore, the impact of TMOF addition to a gasoline surrogate (PRF90) on ignition delay times was studied using the shock tube method at φ = 1.0, 1:5 dilution with N2, T = 900–2000 K, and at 4 bar. The experimental data sets have been compared with predictions of the in-house chemical kinetic reaction mechanism (DLR concise mechanism) developed for interpreting the high-temperature combustion of a broad spectrum of different hydrocarbon fuels as well as oxygenated fuels, including TMOF. The results demonstrate that the ignition delay times of TMOF and OME2 are nearly identical for all pressures studied in the moderate-to high-temperature region. The results obtained for the blend indicate that ignition delay times of the TMOF/PRF90 blend are shorter than those of the primary reference fuel 90 (PRF90) at 4 bar. In the lean-to stoichiometric region, the results obtained for laminar burning velocities of TMOF and OME2 are similar. However, in the fuel-rich domain (φ &gt; 1.0), laminar burning velocities for TMOF are noticeably lower, indicating a decreased reactivity. The model predictions based on the in-house model reveal a good agreement compared to the measured data within the experimental uncertainty ranges. In addition, sensitivity analyses regarding ignition delay times and laminar flame speeds were performed to better understand TMOF oxidation.
Component Tests and Numerical Investigations to Determine the Lifetime and Failure Behavior of End Stage Blades
Authors: Frank Lukas , Weihe Stefan 
Published: September 2022

Abstract
The paper focuses on experimental and numerical fatigue assessment procedures to evaluate the influence of multi-axial stress state caused by high centrifugal forces superimposed with bending loads due to blade vibrations on the lifetime of end stage blades from steam turbines. The experimental investigations on original-sized end stage blades were carried out on a test rig specially developed for high forces and multicomponent force application. This was based on detailed numerical simulations by the MPA University of Stuttgart. During the fractographic postexaminations of the tested blades using magnetic particle inspection, light and scanning electron microscopes, two competing damage mechanisms were identified that occurred at different locations. Numerical investigations by means of elastic–plastic finite element analyses were carried out to estimate the local stress conditions acting in the blade root. The local stresses and strains were postprocessed using the critical plane approach and advanced multi-axial fatigue damage parameters. Due to the high stress gradients at the edge of contact, over-conservative predictions may result if their effects are not taken into account. Based on the critical plane method in conjunction with fatigue damage parameters, an approach taking the stress gradient into consideration was developed to predict the fatigue life of the end stage blades. The approach is verified by the component tests on original-sized blades.
Moscow Clerical Culture of the 14th–15th Centuries: Development Trajectory
Authors: Gryaznov A. 
Published: September 2022

Abstract
The evolution of clerical work and the development of the administrative apparatus in the Moscow principality from the 14th century to the early 16th century are discussed. A characteristic feature of the Muscovite state, the basis of its administrative apparatus, was the prikaz system. Of interest is the stage of its “hidden” functioning, the period of its origin, and the causes and prerequisites for its appearance. The forerunners of the state apparatus of the Muscovite period were the princely treasury and the chancellery. The study of the activities of these institutions and their evolution can go in two directions: an analysis of their direct product, that is, the documents originating from these chancelleries, or clarification of the biographies of the employees of chancelleries and their areas of competence, social ties, and status. The systematization of this information shows that the development of clerical work in Moscow was more intensive than in the other principalities of the region. During the 14th–15th centuries, significant changes took place in almost all areas related to clerical work. Some of the innovations were accepted in the chancelleries of other principalities, some were never implemented. The key to Moscow’s success in the struggle for dominance in Northeastern Russia was the intensive search for new solutions that increased the efficiency of clerical work, information protection, and attention to the distribution of areas of competence and specialization. During the 14th–15th centuries we see the examples of the implementation and use of various certification technologies and options for improving or optimizing clerical work processes. The appearance of paper in Russia was the key moment, the starting point for the implementation of these experiments and the introduction of innovations. Cheap writing material made it possible to benefit more than in the past from the expansion of controlled territories. Taken together, all the consequences of the emergence of paper and increased management efficiency led to the dominance of the Kalitovichs in Northeastern Russia and the creation of a strong, effective regular state.