bluuebunny/crossref_metadata_2025_split huggingface dataset:
Working mechanism of calcium nitrate as an accelerator for Portland cement hydration
Authors: Dorn Tobias , Hirsch Tamino , Stephan Dietmar 
Published: September 2022

AbstractPrecast concrete, cold weather concreting, and the emerging technique of concrete additive manufacturing are applications in which the acceleration of cement hydration plays a critical role. To allow precise control of early cement hydration in these applications, a thorough understanding of the working mechanisms of cement hydration accelerators is required. This study contributes to the understanding of the mechanism by which calcium nitrate (Ca(NO3)2) influences early cement hydration. The influence of Ca(NO3)2 on the hydration of an ordinary Portland cement has been followed by isothermal calorimetry, in situ X‐ray diffraction (XRD), quantitative XRD, compressive strength testing, and the analysis of the pore solution composition. Further, the initial pore solution, the initial phase composition, and the phase composition in the fully hydrated cement have been estimated by thermodynamic calculations to corroborate the experimentally obtained results. The results indicate that Ca(NO3)2, especially at the highest analyzed dosage of 5 wt.%, enhances the formation of ettringite and a nitrate‐containing AFm phase. Furthermore, Ca(NO3)2 accelerates alite hydration. Besides the increased Ca concentration in solution, it has been found that a reduction of the Al concentration in the initial pore solution by Ca(NO3)2 possibly contributes to the accelerating effect of Ca(NO3)2 on alite hydration.
Lung adenocarcinoma with an uncommon CCDC85A‐ALK fusion responding to alectinib: A case report
Authors: Lin Jieheng , Wang Wenping , Lin Jietao , Chen Ruilian , Cao Yang 
Published: September 2022

AbstractA 55‐year‐old Chinese man with a right lung mass and lymph node metastasis (T4N3M0 IIIB) was diagnosed with lung adenocarcinoma after a CT‐guided biopsy. With the wide application of next‐generation sequencing (NGS) in tumour detection, we found a rare CCDC85A‐ALK fusion. The patient received alectinib, which had marked efficacy. This is the first report of a lung adenocarcinoma patient harbouring a new uncommon anaplastic lymphocyte kinase fusion that showed a remarkable response to alectinib. NGS aids in selecting treatment in non‐small cell lung cancer patients.
A 12‐week exercise programme has a positive effect on everyday executive function in young people with Down syndrome: a pilot non‐randomised controlled trial
Authors: Shields N. , Mizzi N. , Buhlert‐Smith K. , Strydom A. , Prendergast L. , Hocking D. R. 
Published: September 2022

AbstractBackgroundExercise has the potential to reduce cognitive decline in people with Down syndrome by maximising their cognitive function. The aim of the study was to determine the effect of regular exercise on cognitive functioning in young people with Down syndrome.MethodPeople with Down syndrome were eligible if aged between 13 and 35 years and enrolled to participate in an exercise programme (called FitSkills). The intervention was a 12‐week community‐based exercise programme completed with a student mentor. Outcomes were assessed before (week 0) and immediately after (week 13) the intervention. Executive functioning (planning, response inhibition, attention shifting) was assessed using Tower of London, Sustained Attention to Response Task, CANTAB Intra‐extra Dimensional Set Shift Test, Cognitive Scale for Down Syndrome, and Behaviour Rating Inventory of Executive Function (BRIEF). Working memory was assessed using the CANTAB Paired Associates Learning task, and information processing speed was assessed using the Motor Screening Task. Outcomes were analysed using ANCOVA with the baseline measure as the covariate.ResultsTwenty participants (9 women; mean age 23.6 ± 6.6 years) enrolled. Between‐group differences, in favour of the experimental group, were found for the global executive composite score of the BRIEF (mean difference −4.77 units, 95% CI −9.30 to −0.25). There were no between group differences for any other outcome measured.ConclusionParticipation in a 12‐week exercise programme was effective in improving everyday executive functions in young people with Down syndrome. These preliminary findings need to be confirmed in future randomised controlled trials of community‐based exercise with larger sample sizes.
Professional grief among nurses in Spanish public health centers after caring for COVID‐19 patients
Authors: Vázquez‐Sánchez María Ángeles , Ayllón‐Pérez Victoria , Gutiérrez‐Sánchez Daniel , Valero‐Cantero Inmaculada , Fernandez‐Ordoñez Eloisa , García‐Gámez Marina , Casals Cristina 
Published: September 2022

AbstractAims and objectivesThe aim of the present study is to investigate the professional grief suffered by nurses in various medical units, after coping with the COVID‐19 pandemic for the last 18 months.BackgroundAddressing and acknowledging the reality of professional grief is of fundamental importance to nurses' mental health, as this condition has both professional and personal consequences.DesignA qualitative, content analysis approach was taken.MethodsBased on 25 interviews with nursing professionals working in different health centers units were performed. The following sampling schemes were used: first, convenience sampling, then nominated sampling, and finally theoretical sampling.ResultsFrom our analysis of the data obtained, three main themes were identified: the impact on nurses of COVID‐19 outcomes; the symptoms of professional grief; and cognitive reactions. These core elements interacted with 12 subtopics, including symptoms of grief and the cognitive impact produced.ConclusionsA large proportion of the nurses consulted in this study have suffered and suffered professional grief and report many related symptoms. In response to the present pandemic and any future occurrence, the question of professional grief needs to be addressed.Relevance to clinical practiceTo help them cope better with this type of situation, nurses should receive appropriate training. Moreover, healthcare institutions should be made aware of the problem and be encouraged to offer assistance to address the impact produced on nurses by the deaths of their patients.Clinical relevanceThis study shows the impact of professional grief on nurses in the context of the COVID‐19 pandemic. Nurses are affected personally by the deaths of patients and by alterations to their working conditions. In many cases, this grief remains unresolved and its various symptoms persist.
Influence of moisturizer containing licochalcone A, 1,2‐decanediol, L‐carnitine, and salicylic acid on facial skin lipidome among seborrhea participants
Authors: Wongtada Chanidapa , Pewlong Putthamas , Asawanonda Pravit , Noppakun Nopadon , Pongpamorn Pornkanok , Paemanee Atchara , Sirikantaramas Supaart , Kumtornrut Chanat 
Published: September 2022

AbstractBackgroundA better understanding of skin lipidomics and its alteration under treatment administration might offer therapeutic solutions for seborrhea.AimsTo quantitatively and qualitatively explore the lipid‐modifying effect of the moisturizer containing licochalcone A, 1,2‐decanediol, L‐carnitine, and salicylic acid (LDCS) in seborrhea participants with and without acne vulgaris (AV).Patients/MethodsWe conducted an open‐label explorative study on 20 seborrhea participants (10 AV and 10 non‐AV). All participants applied LDCS for 8 weeks with the addition of benzoyl peroxide 2.5% gel and adapalene 0.1%/benzoyl peroxide 2.5% gel in AV. Skin surface lipid (SSL) assessments were performed biweekly, using Sebumeter® and lipid‐absorbent Sebutapes® to collect forehead SSL for profile analysis by gas chromatography–mass spectrometry (GC–MS).ResultsSSL amount significantly decreased since week 2 in AV (p‐value = 0.0124) and week 6 in non‐AV (p‐value = 0.0098), respectively. Twenty‐two important SSLs were annotated from GC–MS analysis, comprising 19 free fatty acids, cholesterol, squalene, and glycerol. There was a significant reduction in 5 and 13 lipid components in AV and non‐AV groups, respectively.ConclusionLDCS, either alone or with topical acne treatment, demonstrated substantial sebusuppressive and lipid‐modifying effects among seborrhea participants.
Parents' process of recognition and response to clinical deterioration of their children with medical complexity at home: A grounded theory
Authors: Genna Catia , Thekkan Kiara Ros , Geremia Caterina , Di Furia Michela , Campana Andrea , Dall’Oglio Immacolata , Tiozzo Emanuela , Gawronski Orsola 
Published: September 2022

AbstractAimTo explore the process of recognition and response to clinical deterioration of children with medical complexity at home by their parents.BackgroundChildren with medical complexity are characterised by known chronic conditions associated with frailty and functional limitations, dependence on healthcare services and high use of technology and resources. Their medical complexity often leads to the onset of complications. Targeted care ensures timely recognition and response to clinical deterioration at home, thus avoiding serious sequelae, inappropriate hospitalisations and improving quality of life. Evidence on parents' process of the recognition and response to clinical deterioration at home is limited.DesignQualitative study using a Grounded Theory methodology.MethodSeven online focus groups were conducted with parents and healthcare providers experienced in their care. The interviews were transcribed verbatim and analysed through open, axial and selective coding, using a constant comparative iterative method. The COREQ guidelines guided the reporting of this work.ResultsFour categories and one core category were identified: (1) Awareness of the unique and shared characteristics of children with medical complexity; (2) Parents' care maintenance and management; (3) Parents' care monitoring; (4) Parents' response to clinical deterioration and (5) Seeking the Shift of Agency, the core category as the foundation of the Process of Recognition and rEsponse of PAREnts to Deterioration (PRE‐PARE‐D) theory.ConclusionThe role of parents of children with medical complexity is evolving into active care leaders, by developing care management and care monitoring competences and negotiating care with healthcare providers.Relevance to clinical practiceThe shift of agency from healthcare providers to parents requires education and counselling pathways to promote the development of parent's self‐efficacy, competencies and empowerment in the care management of their children. Home care delivery for children with medical complexity should aim at sustaining this partnership between healthcare providers and parents.
The benefits of Maca (Lepidium meyenii) extract administration for male rabbits affected by environmental heat stress
Authors: Ragab Mona A. , Hassan Mahmoud A. E. , Shazly Soheir A. , El‐Kholany Mohamed E. , Ahmed Mohamed E. , El‐Raghi Ali Ali 
Published: September 2022

AbstractHeat stress (HS) is the most substantial environmental issue in rabbit health status impairment, which can lower productivity. Maca is a common medicinal plant with important biological activities including antioxidant, anti‐inflammatory, anti‐fatigue, and neuroprotective effects. The present research explored the alleged protective role of Maca extract in alleviating the adverse impact of HS on rabbits. Growing V‐line 6‐week‐old buck rabbits (N = 48) were orally administered Maca extract at levels of 0 (MAC0), 200 (MAC2), 400 (MAC4), or 600 (MAC6) mg/head twice per week. Compared to the control groups, rabbits provided Maca had better growth performance, feed intake and feed conversion ratio. Liver and tests weights were significantly higher (p < 0.05) in Maca treated groups compared to the control. hemoglobin, white blood cell, red blood corpuscles, platelet count, hematocrit, and lymphocytes were significantly increased in the MAC4 group compared with the control group. MAC4 treatment significantly reduced aspartate aminotransferase and malondialdehyde levels compared with other groups. Moreover, the concentrations of total bilirubin, creatinine, glucose, total cholesterol, and triglycerides were lower (p < 0.05) in the MAC4 group than in the controls. Oral administration of Maca improved cortisol and testosterone values, total antioxidant capacity, and superoxide dismutase. The MAC4 group exhibited significant improvement (p < 0.05) in sperm motility, survival, membrane functionality, concentration, and libido, with a significant decrease in abnormal sperm compared with the control group. Also, aforementioned group showed sperm cells with a normal structure and intact plasma membranes, acrosomes, and well‐organised axonemal components. Histopathological screening of liver sections showed moderate to severe degenerative and necrotic changes in rabbits exposed to HS, which were alleviated with Maca oral administration. In conclusion, oral administration of Maca extract at 400 or 600 mg/head‐weekly enhanced growth performance, hemato‐biochemical attributes, antioxidant status, and semen quality in rabbits during the hot season.
Novel ABCD1 mutation detected in a symptomatic female carrier of adrenoleukodystrophy
Authors: Nakano Yumiko , Taira Yuki , Sasaki Ryo , Tadokoro Koh , Yunoki Taijun , Nomura Emi , Fukui Yusuke , Takemoto Mami , Morihara Ryuta , Shimozawa Nobuyuki , Yamashita Toru 
Published: September 2022

AbstractWe report a case of a symptomatic female carrier of X‐linked adrenoleukodystrophy (ALD) with a novel ABCD1 gene mutation. She has developed slowly progressive gait disturbance since age 40, and her father and sister had similar symptoms. When admitted to our hospital at age 66, blood analysis showed slight increase of very long‐chain fatty acids (VLCFA), and DNA analysis of ABCD1 gene revealed a novel heterozygous missense mutation (c.1700 A>C, p.Gln567Pro). The genetic testing for ABCD1 gene can be considered in female patients over middle age presenting spastic gait, because female ALD carriers tend to be symptomatic beyond age 60.
Maize plants and the brace roots that support them
Authors: Sparks Erin E. 
Published: September 2022

SummaryBrace roots are a unique but poorly understood set of organs found in some large cereal crops such as maize. These roots develop from aerial stem nodes and can remain aerial or grow into the ground. Despite their name, the function of these roots to brace the plant was only recently shown. In this article, I discuss the current understanding of brace root function and development, as well as the multitude of open questions that remain about these fascinating organs.
A Better Treatment for Moderate to Severe Hallux Valgus: Scarf + Akin Osteotomy Combined with Lateral Soft Tissue Release in a Single Medial Incision
Authors: Xie Wenyong , Lu Hao , Zhan Sizheng , Li Guicheng , Yuan Yusong , Xu Hailin 
Published: September 2022

ObjectiveTraditional lateral soft tissue release (LSTR) was conducted by an additional dorsal first web incision, as the malformed thick scar and neuritis were common after surgery. A new method of lateral soft tissue release in a single medial incision via dorsal flap over the first metatarsal (LSTR‐SMI‐DFFM) should be recommended. The objective is to investigate the clinical effectiveness and safety of scarf + Akin osteotomy (SAO) combined with lateral soft tissue release in a single medial incision via dorsal flap over the first metatarsal (LSTR‐SMI‐DFFM) for moderate to severe hallux valgus.MethodsPatients who were performed surgery for hallux valgus from April 2014 to June 2020 were retrospectively reviewed. The visual analog scale (VAS) was recorded before surgery and during follow‐up, as well as the forefoot score of the American Orthopaedic Foot and Ankle Society (AOFAS). Patient satisfaction was evaluated at the follow‐up time. The preoperative and follow‐up weightbearing X‐ray were conducted in all patients. The radiological parameters of hallux valgus angle (HVA), intermetatarsal angle (IMA), and distal metatarsal articular angle (DMAA) were measured. Tibial sesamoid position (TSP) was also recorded according to seven‐part grading system. The quantitative data were performed as mean ± standard deviation or median ± interquartile range. Student's t test was performed in HVA, IMA, and DMAA. The TSP, VAS, and AOFAS were statistical analyzed by Mann–Whitney U test. p value of <0.05 was considered significant.ResultsThere were 123 feet conducted surgery in 96 patients. The AOFAS score improved a lot which was preoperative 39 to 100 at the follow‐up time and VAS was 4 to 0 (p < 0.001). A total of 63 (51.2%) patients were very satisfied, 47 (38.2%) were satisfied, five (4.1%) were undecided and eight (6.5%) were not satisfied. The HVA, IMA, DMAA, and TSP were all decreased after surgery and were statistically significant (p < 0.001).ConclusionThe SAO combined with a LSTR‐SMI‐DFFM for moderate to severe hallux valgus is effective and safe with pretty good clinical and radiographic results, as well as minimal complications. The corrections of AOFAS and VAS conformed to the minimum clinically important difference (MCID).
Managing recurrent portal steal in auxiliary liver transplantation for non‐cirrhotic metabolic liver disease
Authors: Vasudevan Anu K. , Shanmugam Naresh P. , Rammohan Ashwin , Rela Mohamed 
Published: September 2022

AbstractBackgroundAPOLT has been proposed as a treatment modality for certain types of NCMLD. While the short‐term outcomes of this operation have been comparable with orthotopic LT, its long‐term outcomes have sparsely been reported. We present one such case of Citrullinemia type I who underwent APOLT and developed recurrent PS.Case ReportA 2‐year‐old male child with a diagnosis of Citrullinemia type I underwent APOLT with a left lateral segment from a split deceased donor liver, and his postoperative period was unremarkable. Ammonia‐lowering agents were stopped 1 week following the operation and the child was discharged home on a normal diet. Four years following APOLT, the child presented with altered sensorium and seizures. A diagnosis of PS was made. Subsequent to an embolization of the native liver's right anterior portal vein his sensorium improved and he remained clinically stable on a normal diet. Six years following the APOLT, the child again presented with features of acute encephalopathy. Imaging was suggestive of PS. A portal vein embolization of the native portal vein was performed and the child's clinical condition improved. At 6 months' follow‐up, the child remains well on a normal diet.ConclusionsWhile the early impediments in this technique may have been overcome, in the absence of any realistic clinical application gene therapy, the debate of long‐term phenotypic metabolic correction for NCMLD by APOLT needs to be revisited.
Whole blood transfusion and paroxysmal nocturnal haemoglobinuria meet again: Minor incompatibility, major trouble
Authors: Lægreid Ingvild Jenssen , Wilson Thomas , Næss Kristoffer Hjertø , Ernstsen Siw Leiknes , Schou Vibeke , Arsenovic Mirjana Grujic 
Published: September 2022

AbstractBackground and ObjectivesThe field of transfusion medicine started out with whole blood transfusion to treat severe anaemia and other deficiencies, and then transitioned to component therapy, largely leaving the practice, and experiences, of whole blood transfusions behind. Currently, the field is circling back and whole blood is gaining ground as an alternative to massive transfusion protocols.Materials and MethodsHerein we describe a severely anaemic paroxysmal nocturnal haemoglobinuria (PNH) patient initially suspected of suffering from renal haemorrhage, receiving a standard low‐titre group O whole blood transfusion during pre‐hospital transportation.ResultsFollowing the transfusion, the patient suffered a clinically unmistakable haemolytic transfusion reaction requiring supportive treatment in the intensive care unit. Clinical observations are consistent with an acute haemolytic reaction. The haemolysis was likely due to minor incompatibility between the plasma from the transfused whole blood and the patient's PNH red cells. Recovery was uneventful.ConclusionThis revealed an unappreciated contraindication to minor incompatible whole blood transfusion, and prompted a discussion on the distinction between whole blood and erythrocyte concentrates, the different indications for use and the importance of emphasizing these differences. It also calls attention to patient groups where minor incompatibility can be of major importance.
Fatal haemolytic transfusion reaction due to anti‐Ena and identification of a novel GYPA c.295delG variant in a Thai family
Authors: Suwanwootichai Ploymanee , Lopez Genghis H. , Emthip Morakot , Wilson Brett , Millard Glenda M. , Onpuns Sunisa , Laemsri Kanchana , Bejrachandra Sasitorn , Liew Yew‐Wah 
Published: September 2022

AbstractBackground and ObjectivesHigh‐frequency antigen Ena (MNS 28) is expressed on glycophorin A (GPA). En(a−) individuals can form anti‐Ena when exposed to GPA. A Thai patient formed an antibody that reacted against all reagent red blood cells (RBCs). The patient received incompatible blood resulting in a fatal haemolytic transfusion reaction (HTR). This study aimed to characterize the antibody detected in the patient and investigate the cause of HTR.Materials and MethodsBlood samples from the patient and three of his family members were investigated. Massively parallel sequencing (MPS) and DNA‐microarray were used for genotyping. Standard haemagglutination techniques were used for phenotyping and antibody investigations.ResultsDNA sequencing showed the patient was homozygous for GYPA*M c.295delG (p.Val99Ter) predicting En(a−). Three family members were heterozygous for GYPA c.295delG. MPS and DNA‐microarray predicted the patient was N− discordant with the N+ RBC phenotype. The patient's plasma was positive with enzyme/chemical‐treated reagent RBCs but failed to react with En(a−) and MkMk RBCs.ConclusionThe GYPA c.295delG variant prevented GPA expression on RBCs resulting in En(a−) phenotype. The N+ phenotype result was probably due to the anti‐N typing reagent detecting ‘N’ (MNS30) on GPB. The patient's alloantibody has anti‐Ena specificity.
Modelling the outcomes of different red blood cell transfusion strategies for the treatment of traumatic haemorrhage in the prehospital setting in the United Kingdom
Authors: Roberts Barnaby , Green Laura , Ahmed Venus , Latham Tom , O'Boyle Peter , Yazer Mark H. , Cardigan Rebecca 
Published: September 2022

AbstractBackground and ObjectivesThe limited supply and increasing demand of group O RhD‐negative red blood cells (RBCs) have resulted in other transfusion strategies being explored by blood services that carry potential risks but may still provide an overall benefit to patients. Our aim was to analyse the potential economic benefits of prehospital transfusion (PHT) against no PHT.Materials and MethodsThe impact of three PHT strategies (RhD‐negative RBC, RhD‐positive RBC and no transfusion) on quality‐adjusted‐life‐years (QALYs) of all United Kingdom trauma patients in a given year and the subset of patients considered most at risk (RhD‐negative females <50 years old), was modelled.ResultsFor the entire cohort and the subset of patients, transfusing RhD‐negative RBCs generated the most QALYs (141,899 and 2977, respectively), followed by the RhD‐positive RBCs (141,879.8 and 2958.8 respectively), and no prehospital RBCs (119,285 and 2503 respectively). The QALY difference between RhD‐negative and RhD‐positive policies was smaller (19.2, both cohorts) than RhD‐positive and no RBCs policies in QALYs term (22,600 all cohort, 470 for a subset), indicating that harms from transfusing RhD‐positive RBCs are lower than harms associated with no RBC transfusion. A survival increase from PHT of 0.02% (entire cohort) and 0.7% (subset cohort) would still make the RhD‐positive strategy better in QALYs terms than no PHT.ConclusionWhile the use of RhD‐positive RBCs carries risks, the benefits measured in QALYs are higher than if no PHT are administered, even for women of childbearing potential. Group O RhD‐positive RBCs could be considered when there is a national shortage of RhD‐negative RBCs.