bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of facial application of essence containing royal jelly extract on stratum corneum moisture content: A placebo‐controlled, double‐blind, parallel‐group study
Authors: Maeda Yuka , Fujikura Chizuru , Asama Takashi , Yagi Masayuki , Okumura Nobuaki , Yamaki Ayanori , Ohkuma Akio , Numano Kayoko 
Published: July 2022

AbstractObjectivesTo evaluate the moisturizing function and other effects of royal jelly extract on the skin. The effects of applying an essence containing royal jelly extract on the skin of healthy Japanese males and females were examined.MethodsThirty‐five healthy Japanese men and women who were aware of their skin dryness applied an essence containing royal jelly extract or placebo for 4 weeks using the split‐face method in a placebo‐controlled, double‐blind, parallel comparative study. The stratum corneum water content, transepidermal water evaporation, pigmentation, pores, and redness were evaluated.ResultsThe stratum corneum water content significantly increased by the application of essence containing royal jelly extract to the cheeks for 4 weeks compared with placebo.ConclusionThe application of an essence containing royal jelly extract significantly improved the moisture content of the stratum corneum of the cheeks, confirming the improvement in the moisturizing function of the royal jelly extract. Furthermore, no adverse events were observed at the application site during the application period, and the test products and royal jelly extract contained in the test product were considered highly safe.
Non‐invasive system delivering microwaves energy for unwanted fat reduction and submental skin tightening: Clinical evidence
Authors: Salsi Benedetta , Fusco Irene 
Published: July 2022

AbstractBackgroundCervicomental contour represents an important aesthetic problem.AimsThis research evaluates the safety and the efficacy of a new non‐invasive system delivering microwave energy for the treatment of submental skin laxity and fat.MethodsForty‐eight subjects underwent submental treatment with the device at hand at Poliambulatorio San Michele, Reggio Emilia, Italy. The treatment was performed on the submental area starting from 1.5 cm below the lower border of the mandible up to the hyoid bone. Treatment consisted of 6 sessions of 10 min, with a 2‐week interval between each session. At the baseline and upon follow‐up 12 weeks from the last treatment, the following evaluations were performed: Photographic evaluation, Clinician‐Reported Submental Fat Rating Scale (CR‐SMFRS), Submental Skin Laxity Grade (SMSLG), Five‐Point Likert Scale Questionnaire (LSQ) for Skin Laxity, Patient‐Reported Submental Fat Rating Scale (PR‐SMFRS) and Numeric Rating Scale (NRS) for pain evaluation.ResultsMean submental fat and laxity scores evaluation significantly decrease respectively from 3.4 ± 0.5 and 3.7 ± 0.5 at baseline to 1.7 ± 0.6 and 2.4 ± 0.6 (p < 0.01) at 12‐week follow‐up after the last treatment. The treatment was well‐tolerated according to the NRS results. Out of the 47 participants (70.2%), 33 were very satisfied or satisfied. Most patients denied experiencing any discomfort during and after the treatment with the non‐invasive device delivering microwaves. The submental subcutaneous fat reduction, the improvement of submental skin tightening, and aesthetic results are confirmed also by photographic evaluation. No side effects were observed.ConclusionsOur results showed the potential microwaves role in the treatment of localized submental subcutaneous adiposities and skin laxity.
Tissue factor pathway inhibitor 2: A potential diagnostic marker for discriminating benign from malignant ovarian tumors
Authors: Kobayashi Hiroshi , Yamada Yuki , Kawaguchi Ryuji , Ootake Norihisa , Myoba Shohei , Kimura Fuminori 
Published: July 2022

AbstractObjectivesCarbohydrate antigen 125 (CA125), CA19‐9, carcinoembryonic antigen (CEA), human epididymis protein 4 (HE4), and the Risk of Ovarian Malignancy Algorithm (ROMA) are widely used as tumor markers and algorithms for the diagnosis of ovarian cancer (OC). Tissue factor pathway inhibitor 2 (TFPI2) has been developed as a potential serodiagnostic marker for OC in Japan. The aim of this study is to evaluate the diagnostic accuracy of the six markers alone and in combination to find the best marker for discriminating between benign and malignant ovarian tumors.MethodsFrozen serum samples collected from 484 patients were divided into three groups based on histopathological results: OC (n = 119), borderline ovarian tumors (BR) (n = 48), and benign ovarian tumors (BN) (n = 317). Diagnostic accuracy was calculated with an area under a receiver operating characteristic (AUC) curve.ResultsTFPI2 achieved the highest discrimination between the OC + BR group versus the BN group (AUC 0.8076). ROMA values best discriminated patients with OC from those with BN (AUC, 0.8966), which was equivalent to TFPI2 (AUC, 0.8937). For discriminating the OC group from the BR + BN group, the highest AUC value was achieved by ROMA values (AUC, 0.8884), and TFPI2 also showed comparable diagnostic accuracy (AUC, 0.8845). Combining TFPI2 with ROMA had the highest AUC (0.8420–0.9357).ConclusionTFPI2 may be a clinically useful single marker comparable to conventional ROMA values for discriminating between benign and malignant ovarian tumors.
Buddhist Entrepreneurs, Managerial Attention Allocation, and New Ventures' Access to External Resources
Authors: Xu Zuhui , Tang Yi , Liu Zhiyang 
Published: July 2022

AbstractNew ventures are often short of resources crucial to their survival and development. This research sheds new light on how new ventures can obtain better access to external resources by analysing a survey of a large sample of Chinese private entrepreneurs. We found that by comparison with their non‐Buddhist counterparts, Chinese Buddhist entrepreneurs tend to give greater attention to external activities and have a higher chance of gaining sociopolitical legitimacy and therefore have a better chance of accessing external resources such as bank loans. Moreover, the indirect effect on bank loans of the amount of attention allocated to external activities by Chinese Buddhist entrepreneurs is weakened by lower government intervention and better development of intermediary agencies in regions where new ventures are located, largely due to Chinese Buddhist entrepreneurs' reduced reliance on sociopolitical legitimacy to access external resources.
Circ_0058063 contributes to oral squamous cell carcinoma development by sponging miR‐145‐5p and upregulating SERPINE1
Authors: Yu Jie , Lou Ying , Hou Ming , Ma Xin , Wang Lu 
Published: July 2022

AbstractBackgroundWe aimed to demonstrate the effects circ_0058063 exerted on oral squamous cell carcinoma (OSCC) and its downstream mechanism associated with miR‐145‐5p and SERPINE1.MethodsThe relevant contents of miR‐145‐5p, circ 0058063, and SERPINE1 mRNAs in OSCC were evaluated using quantitative reverse transcription polymerase chain reaction. Functional experiments including CCK‐8, Transwell, Western blot, and in vivo experiment were implemented to investigate the biological impacts on OSCC cells. Using dual‐luciferase reporter, RIP, and RNA pull‐down assays, the direct binding relationship between miR‐145‐5p, circ 0058063, and SERPINE1, SMAD3, CYR61, and IGF1R mRNAs was verified.ResultsIn OSCC, Circ 0058063 was significantly overexpressed. Knockdown of circ_0058063 suppressed OSCC cell migration and proliferation, but enhanced cell apoptosis. Functionally and mechanistically, circ_0058063 could specifically bind with miR‐145‐5p and thus upregulated expression of downstream target SERPINE1, which together contributed to the progression of OSCC.ConclusionCirc_0058063 could promote the malignant behavior of OSCC by upregulating SERPINE1 through sponging miR‐145‐5p.
Donor and recipient safety in human milk banking
Authors: Clifford Vanessa , Klein Laura D , Brown Richard , Sulfaro Christine , Hoad Veronica , Gosbell Iain B , Pink Joanne 
Published: July 2022

AimAustralian Red Cross Lifeblood supplies pasteurised donor human milk (PDHM) to more than 30 partner hospitals across Australia. Preterm infants who receive PDHM are a highly vulnerable population but formal biovigilance programs are rare in human milk banking. Lifeblood Milk performs ongoing surveillance for both donor and recipient adverse events. This study aimed to formally review adverse events reported to Lifeblood Milk since 2018.MethodsMilk donor infectious diseases testing outcomes and donor adverse events (DAEs) are prospectively recorded at Lifeblood. Infant recipient adverse events are contractually reported back to Lifeblood Milk by hospitals and assessed according to severity and likelihood of relationship to PDHM administration. Donor and recipient adverse events over a 3.5‐year period (July 2018 to December 2021) were reviewed.ResultsThere were three DAEs (3/976 = 0.31%) related to phlebotomy; these included two vasovagal reactions and one phlebotomy site haematoma. Eight (8/976 = 0.81%) additional donors had biological false reactive (BFR) infectious diseases serology results. There were 10 reported suspected adverse events in recipients. Six were infection‐related; other events included milk curd obstruction, high urinary iodine levels, sudden cardiac death and nasogastric tube obstruction. All reported suspected adverse events in recipients were classified as unlikely to be related, or definitely not related, to PDHM administration.ConclusionsMilk donor adverse events were rare but biological false reactive serology results were not uncommon. There were no recipient adverse events considered causally related to pasteurised donor human milk, which is generally a low‐risk biological product. Ongoing biovigilance remains essential.
Rectal measurements and their correlation with bowel habits: Evaluation by trans‐abdominal ultrasound in children with functional constipation
Authors: Shapouri Samaneh , Matani Rahman , Salahshoor Ali , Qorbani Mostafa , Hosseini Amirhossein , Norouzi Mahsa , Khavandegar Armin 
Published: July 2022

AimConstipation is one of the most common complaints in childhood affecting the quality of life of both children and parents. This study intends to investigate rectal measurements on ultrasound and their relationship with bowel habits.MethodsIn this cross‐sectional study, 100 children with functional constipation (FC) referred to a single hospital between 2018 and 2019 were enrolled. After obtaining informed consent, a questionnaire including demographic and constipation characteristics was completed, and a physical examination including digital rectal examination (DRE) was performed. Complete abdominopelvic ultrasound was then performed. Target measurements included rectal transverse diameter (RTD), rectal anterior wall thickness (RAWT) and the presence of faecal impaction.ResultsOne hundred children with a mean age of 7.68 ± 3.30 years were present in the study. The mean duration of constipation was 15.86 ± 13.34 months. In 14% of children, painful defaecation was reported. 88% of children had some degree of faecal incontinence. According to the ultrasound findings, the mean RTD and RAWT were 3.39 ± 0.73 cm and 2.77 ± 0.68 mm, respectively, and faecal impaction was present in 70% of cases. There was a positive correlation between RTD and RAWT with age, duration of constipation and the presence of hard stools, and there was a negative correlation with frequency of defecation (P < 0.05).ConclusionRTD and RAWT increased with increasing constipation duration and the presence of hard stools and decreased with increasing frequency of defaecation. DRE could be omitted from the initial clinical assessment if you had access to reliable ultrasound data.
Synergistic effects of probiotic Bifidobacterium isolated from chicken's intestine in combination with polyvinylpyrrolidone on reduction of aflatoxin B1
Authors: Aalipanah S. , Fazeli M.R. , Akhavan Sepahi A. , Shariatmadari F. 
Published: July 2022

Abstract
Food contamination with aflatoxin is one of the most critical concerns of health professionals. One of the best ways to reduce aflatoxin content in food is probiotics. Therefore, this study was performed to isolate Bifidobacterium from the chick's intestine; evaluate its probiotic activities and its application with Polyvinylpyrrolidone (PVP) to reduce aflatoxin B1 (AFB1) in the medium were investigated. Samples were isolated from the chick's intestine, and Bifidobacterium was isolated and identified by biochemical and molecular methods. Next, the potential probiotic characterization was assessed. Afterwards, the effect of selected isolate and PVP on reducing AFB1 in the medium was studied using ELISA and HPLC. Biochemical and molecular evaluations indicated isolation of Bifidobacterium bifidum strain from chick's intestine. One of the B. bifidum strains was selected for the next steps, which showed potential probiotic characterization and the ability to reduce the concentration of AFB1 in the medium (50% reduction). When used in combination with PVP showed synergistic effects in reducing the concentration of AFB1 from the medium (up to 90%). In the conclusion, it was found that selected B. bifidum strains and PVP could have synergistic effects in reducing AFB1 toxin in a medium up to 90%.
Currency returns and systematic risk
Authors: Gonçalves Fernanda , Ferreira Giuliano , Ferreira Alex , Scatimburgo Pedro 
Published: July 2022

AbstractWe investigate the relationship between currency excess returns and Gross Domestic Product (GDP) in a Consumption Capital Asset Pricing Model. GDPs are observable systematic risk factors in our asset pricing equations. The correlation between the unobservable systematic factors is explored by Seemingly Unrelated Regressions estimations. The sample comprises the period from 1999:M01 to 2019:M12 and 48 countries. Results show that GDP growth risk is significant for most currency pairs and portfolios. We also find that they are priced in the cross‐section of excess returns. Furthermore, currency returns are directly affected by regional business cycles (Europe, America, and Asia).
Genetic variability and the ecology of geographic range: A test of the central‐marginal hypothesis in Australian scincid lizards
Authors: Singhal Sonal , Wrath John , Rabosky Daniel L. 
Published: July 2022

AbstractFor many species, both local abundance and regional occupancy are highest near the centre of their geographic distributions. One hypothesis for this pattern is that niche suitability declines with increasing distance from a species geographic centre, such that populations near range margins are characterized by reduced density and increased patchiness. In these smaller edge populations, genetic drift is more powerful, leading to the loss of genetic diversity. This simple verbal model has been formalized as the central‐marginal hypothesis, which predicts that core populations should have greater genetic diversity than edge populations. Here, we tested the central‐marginal hypothesis using a genomic data set of 25 species‐level taxa of Australian scincid lizards in the generaCtenotusandLerista. A majority of taxa in our data set showed range‐wide patterns of genetic variation consistent with central‐marginal hypothesis, and eight of 25 taxa showed significantly greater genetic diversity in the centre of their range. We then explored biological, historical, and methodological factors that might predict which taxa support the central‐marginal hypothesis. We found that taxa with the strongest evidence for range expansion were the least likely to follow predictions of the central‐marginal hypothesis. The majority of these taxa had range expansions that originated at the range edge, which led to a gradient of decreasing genetic diversity from the range edge to the core, contrary to the central‐marginal hypothesis.
WWOM VII: Effectiveness of topical interventions in the management of burning mouth syndrome: A systematic review
Authors: Goncalves Sandra , Carey Barbara , Farag Arwa M. , Kuten‐Shorrer Michal , Natto Zuhair S. , Ariyawardana Anura , Mejia Lina M. , Chmieliauskaite Milda , Miller Craig S. , Ingram Mark , Nasri‐Heir Cibele , Sardella Andrea , Carlson Charles R. , Klasser Gary D. , O'Neill Francis , Albuquerque Rui 
Published: July 2022

AbstractObjectivesTo assess the effectiveness of topical interventions in the management of burning mouth syndrome (BMS), based on the core outcome domains recommended by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT).MethodsA systematic literature review of RCTs on topical interventions for the management of BMS, published in PubMed, Web of Science, PsycInfo, Cochrane Database/Central, and Google Scholar through May 2021 was performed.ResultsEight RCTs (n = 358 study participants) were included in this study. Due to underreporting of IMMPACT domains, publication bias, high degree of heterogeneity between studies, meta‐analysis was not undertaken. Based on changes in visual analogue pain scores (ΔVAS), the most reported outcome, the effectiveness of the topical interventions was demonstrated; however, it is low level of evidence.ConclusionsHigh levels of variability (interventions, outcomes, outcome measurement tools, and intervention effects evaluated), heterogeneity, publication bias, and underreporting of IMMPACT domains were observed across the RCTs. This systematic review highlights the need for application of standardized outcome measures to future RCTs. At the present time, there is lack of moderate‐strong evidence on short‐ and long‐term outcomes to support or refute the use of any particular topical intervention in managing BMS. Future RCTs with standardized outcome measures are needed.
Fanconi anemia and haploidentical stem cell transplantation
Authors: Medina‐Valencia Diego , Aristizabal Ana Maria , Beltran Estefania , Franco Alexis A. 
Published: July 2022

AbstractBackgroundFanconi anemia is a congenital disorder belonging to bone marrow syndromes, with a risk of developing malignancy. Hematopoietic stem cell transplantation is the only curative treatment in these cases. Here, we aimed to report our clinical experience in pediatric patients with Fanconi anemia treated with haploidentical stem cell transplantation and post‐transplant cyclophosphamide, an alternative strategy.MethodsWe performed a case report based on clinical records of two patients who signed the informed consent form and were treated at Fundación Valle del Lili.ResultTwo pediatric patients, both with reduced‐intensity conditioning, prophylaxis for acute graft‐versus‐host disease with post‐transplant cyclophosphamide. They achieved primary neutrophil/platelets engraftment, and 100% chimerism. Had grade I or II graft‐versus‐host disease resolved? Currently are alive and in complete remission.ConclusionsThe use of mismatched related donors for haploidentical stem cell transplantation and post‐transplant cyclophosphamide might be a promising option, and well‐tolerated in pediatric patients. Serial chimerism can be useful during follow‐up.
Clinical indicators of slow graft function and outcome after pediatric kidney transplantation
Authors: Bajaj Sargun , Gershony Sharon , Afshar Kourosh , Blydt‐Hansen Tom David 
Published: July 2022

AbstractBackgroundLesser degrees of perioperative ischemia–reperfusion injury that does not require dialysis may nonetheless influence allograft outcomes, necessitating evaluation of suitable surrogate indicators of perioperative allograft injury.MethodsThis retrospective analysis of pediatric kidney transplants evaluated two indicators representing pace and completeness of recovery, for association with 12‐month estimated glomerular filtration rate (eGFR) and first‐year rate of eGFR decline: time to creatinine nadir (TTN) and ratio of recipient/donor unadjusted GFR (uGFRR/D) at 1‐month post‐transplant. Donor, recipient, and perioperative risk factors were tested further for association with these 2 indicators.Results179 patients (190 transplants) aged 13 (IQR 7–17) years and 56% male were included. Twelve‐month eGFR was strongly associated with unadjusted GFR at 1 month (uGFR1M, p < .001) and uGFRR/D (p = .003), but not with TTN. None of the indicators was associated with the rate of subsequent eGFR decline after 1‐month post‐transplant. As a potential surrogate indicator, uGFR1M is effectively modeled by TTN and uGFRR/D (adjusted R2 = 0.57) and is associated with 12‐month eGFR (β = 0.81 ± 0.08; p < .001). Clinical factors associated with uGFRR/D included donor uGFR (p < .001), BSA (p = .026), age (p = .074), and recipient BSA (p < .001). Factors associated with pace of recovery (TTN) included donor uGFR (p = .018), type (p = .019), and recipient BSA (p = .022).ConclusionsThe uGFRR/D ratio, but not TTN, is a useful indicator of perioperative allograft damage that is associated with one‐year functional outcome; and uGFR1M is a potential early surrogate outcome. Donor, recipient, and perioperative factors that are associated with slow allograft function are identified.
Bayesian dithering for learning: Asymptotically optimal policies in dynamic pricing
Authors: Huh Woonghee Tim , Kim Michael Jong , Lin Meichun 
Published: July 2022

We consider a dynamic pricing and learning problem where a seller prices multiple products and learns from sales data about unknown demand. We study the parametric demand model in a Bayesian setting. To avoid the classical problem of incomplete learning, we propose dithering policies under which prices are probabilistically selected in a neighborhood surrounding the myopic optimal price. By analyzing the effect of dithering in facilitating learning, we establish regret upper bounds for three typical settings of demand model. We show that the dithering policy achieves an upper bound of order [Formula: see text] when the parameter set is finite. It can be modified to achieve a constant regret bound under an additional assumption. We also prove an upper bound of order [Formula: see text] when the parameter set is compact and convex. Each bound matches (up to a logarithmic factor) the existing lower bound of any pricing policy. In this way, we show that dithering policies achieve asymptotically optimal performance in three different parameter settings, which demonstrates dithering as a unified approach to strike the balance between exploration and exploitation.
Systematic construction of non‐autonomous Hamiltonian equations of Painlevé‐type. III. Quantization
Authors: Błaszak Maciej , Marciniak Krzysztof 
Published: July 2022

AbstractThis is the third article in our series of articles exploring connections between dynamical systems of Stäckel‐type and of Painlevé‐type. In this article, we present a method of deforming of minimally quantized quasi‐Stäckel Hamiltonians, considered in Part I to self‐adjoint operators satisfying the quantum Frobenius condition, thus guaranteeing that the corresponding Schrödinger equations possess common, multitime solutions. As in the classical case, we obtain here both magnetic and nonmagnetic families of systems. We also show the existence of multitime‐dependent quantum canonical maps between both classes of quantum systems.