bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Solidarity and Collective Intelligence in Times of Pandemics
Authors: Martí José Luis 
Published: January 2022

Global Solidarity and Collective Intelligence in Times of Pandemics
Some of the existential threats we currently face are global in the sense that they affect us all, and thus matter of global concern and trigger duties of moral global solidarity. But some of these global threats, such as the COVID-19 pandemic, are global in a second, additional, sense: discharging them requires joint, coordinated global action. For that reason, these twofold global threats trigger political – not merely moral – duties of global solidarity. This article explores the contrast between these two types of global threats with the purpose of clarifying the distinction between moral and political duties of global solidarity. And, in the absence of a fully developed global democratic institutional system, the article also explores some promising ways to fulfill our global political duties, especially those based on mechanisms of collective intelligence such as CrowdLaw, which might provide effective solutions to these global threats while enhancing the democratic legitimacy of public decision-making.
Decision entity-ness: taking agency seriously in organizational decision-making studies
Authors: Villar Eduardo Guedes , Roglio Karina De Déa 
Published: January 2022

Objective of the study: In this essay, we problematize the onto-epistemological assumptions of organizational decision-making theories, focusing on the concepts of action and decision.Approach: Based on the epistemological perspective of transaction, we propose an understanding of decision as a relational element of action and in action, constructing an explanation supported on the relational ontological understanding of reality.Originality/relevance: We introduce the concept of decision entity-ness, based on relational sociology from the perspective of transaction and the idea of relational agency.Main results: The concept of decision entity-ness allowed us to theoretically combine the processual and performative dimensions of organizational decision-making.Theoretical contribution: As a contribution, we developed an original theoretical-explanatory framework that emphasizes decision, understanding it as an element that distinguishes organizations from other social systems.
Human-Animal Interactions and Infectious Disease
Authors: Littleton Judith , Karstens Sarah , Busse Mark , Malone Nicholas 
Published: January 2022

Zoonoses are significant in human histories, and in histories of other species and the environment. Diseases have been an important evolutionary force, not just the major epidemics but the quieter endemic diseases. These infectious diseases comprise complex events and cycles involving multiple actors (humans, animals, and microorganisms). Despite difficulties of preservation, identification, and interpretation, bioarchaeologists have often analyzed zoonotic diseases. However, these studies have tended to focus on an individual disease and its emergence as opposed to the human-animal interactions and complex environmental cycles that underlie zoonotic disease more broadly. In this paper, after a brief review of zoonotic disease and bioarchaeological studies of it, we provide three contemporary case studies that point to the complexity of human-animal interaction and the socioecological circumstances involved in disease. We argue that adopting a One Health framework, which is based on Rudolf Virchow’s insight as well as approaches that emphasize time depth, multiple analytical scales, evolutionary understandings, and a consideration of human ideas and not just practices, would contribute to making bioarchaeology relevant to contemporary and future issues beyond the epidemiological transition model as modified by Barrett and Armelagos (Barrett et al. 1998; Barrett and Armelagos 2013).

Les zoonoses sont importantes dans l’histoire humaine, et en gros dans l’histoire d’autres espèces et de l’environnement. Les maladies ont été une force évolutive importante, non seulement les épidémies majeures, mais aussi les maladies endémiques les plus calmes. Ces maladies infectieuses comprennent des événements et des cycles complexes impliquant de multiples acteurs (humains, animaux et micro-organismes). Malgré les difficultés de préservation, d’identification et d’interprétation, les bioarchéologues ont souvent analysé les zoonoses. Cependant, ces études ont eu tendance à se concentrer sur la maladie individuelle et son émergence par opposition aux interactions homme-animal et aux cycles environnementaux complexes qui sous-tendent la maladie zoonotique de manière plus générale. Dans cet article, après un bref examen de la maladie zoonotique et des études bioarchéologiques de celle-ci, nous fournissons trois études de cas contemporaines qui soulignent la complexité de l’interaction homme-animal et les circonstances socio-écologiques impliquées dans la maladie. Nous soutenons que l’adoption d’un cadre One Health basé sur la vision de Rudolf Virchow ainsi que sur des approches mettant l’accent sur la profondeur temps, les échelles analytiques multiples, les compréhensions évolutives et la prise en compte des idées humaines et non seulement des pratiques, contribuera à rendre la bioarchéologie pertinente pour les problèmes contemporains et futurs au-delà le modèle de transition épidémiologique tel que modifié par Barrett et Armelagos (Barrett et al. 1998; Barrett et Armelagos 2013).
Contributing by Monitoring Energy Efficiency to the Development of Optimization Measures to Improve Energy Performance in an Industrial Platform
Authors: Constantin Lipan Laurentiu 
Published: January 2022

Greenhouse gas emissions and climate change are currently major international problems. This makes it important to increase energy efficiency. The implementation of energy efficiency improvement measures has reduced energy demand for industrial platforms, so that energy plans designed before these measures are no longer appropriate for current tasks (extensions are not considered at this time). I intended to give a clear image and a better understanding of the factories’ power consumption (the industrial area in question is located near a city). A power plant-specific power system is quite disruptive, as can be seen from the monitored data at the power plant users and from the general power supply voltage bars (110 kV, 20 kV) as well as from the voltage bars of the adjacent users. Based on real-time measurements and monitoring devices, the following characteristic curves have been extracted for local energy systems. That is because data analysis is easy to be used for monitoring energy efficiency and elaborating optimization measures to improve power performance.
Assessment of ALK Fusions in Uncommon Inflammatory Myofibroblastic Tumors With ALK IHC Positivity but FISH-Equivocal Findings by Targeted RNA Sequencing
Authors: Yao Qianlan , Bai Qianming , Zhang Xin , Ji Gang , Chang Heng , Cai Xu , Yu Lin , Wang Jian , Zhu Xiaoli , Zhou Xiaoyan 
Published: January 2022

Context.—
Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) are common methods to detect ALK status in inflammatory myofibroblastic tumors (IMTs). However, equivocal ALK FISH signals and inconsistency between FISH and IHC are occasionally observed.

Objective.—
To study the inconsistency between FISH and IHC, and clarify ALK status in IMT by targeted RNA sequencing (RNAseq).

Design.—
In this study, 12 consultation cases preliminarily diagnosed as uncommon IMTs with ALK IHC positivity but FISH negativity, plus 3 ALK-positive and 3 ALK-negative IMTs, were re-analyzed by IHC, FISH, and RNAseq.

Results.—
As a result, 1 case with FUS-TFCP2 fusion was detected by RNAseq, which was previously misdiagnosed as IMT. In the other 11 uncommon IMTs, 90.9% (10 of 11) showed equivocal ALK FISH signals, and all were confirmed to harbor ALK fusion by RNAseq, except for 1 failure, suggesting that a low threshold for ALK FISH might be proposed in IMT. Furthermore, RNAseq also identified IGFBP5-ALK in 1 case with ALK IHC positivity but typical FISH negativity, suggesting the possibility of false negatives for ALK FISH. For the typical IMTs, ALK fusion was identified by RNAseq in all 3 ALK-positive IMTs as expected, and additionally FN1-ROS1 fusions were identified in 2 of 3 ALK-negative IMTs.

Conclusions.—
These findings indicated that RNAseq can simultaneously detect multiple gene fusions and provide fusion forms and breakpoints, which is of great value for differential diagnosis, especially for those uncommon IMTs with equivocal FISH findings or inconsistency between IHC and FISH.
O Transcorrer do Tempo em Schopenhauer: Recorrência, Lembrança, Memória e História
Authors: Ribeiro da Fonseca Eduardo 
Published: January 2022

Este artigo é uma reflexão acerca dos sentidos da transitoriedade em Schopenhauer, na medida em que conhecemos as conclusões da metafísica imanente sobre o Nunc Stans ao fundo do transcorrer do tempo, a roda da Vontade Cósmica girando fora do tempo, do espaço e da causalidade. O diálogo que aparece ao fundo do texto será estabelecido a partir do contraste das concepções de eterno retorno em Schopenhauer e Nietzsche, mas abrange noções da Psicanálise de Freud e os comentários literários de Jorge Luiz Borges. Em sentido específico, o eterno retorno em Schopenhauer se caracteriza pela recorrência do sofrimento e das formas efetivas, consideradas por Schopenhauer a partir do dogma de Plotino, o das ideias platônicas. Tais ideias, como atos originários da vontade, continuamente reinstauram o mundo, ainda que as formas específicas expressem as ideias já no âmbito da representação submetida ao princípio de razão, ou, em outras palavras, no âmbito da causalidade. A pergunta sobre os lugares correspondentes à lembrança, à memória e à História nos instiga justamente pelo caráter imanente da filosofia de Schopenhauer, para quem a pergunta sobre o mundo deveria ser respondida a partir do próprio mundo.
Sobre o problema da alteridade na Ética da Compaixão: considerações sobre a crítica de Byung-Chul Han a Schopenhauer
Authors: Chevitarese Leandro 
Published: January 2022

Na filosofia de Schopenhauer, o fundamento da moral é a compaixão [Mitleid], que repousa na supressão da distinção egoísta entre minha pessoa e qualquer outro indivíduo. O filósofo contemporâneo Byung-Chul Han, em seu livro Filosofia do Zen-budismo, considera que “a compaixão (...) não se deve à identificação ou a se pôr no lugar do outro [Einfühlung]”. Ao analisar a filosofia de Schopenhauer, tendo em vista sua influência oriental e, em contraste com as concepções do zen-budismo, o autor afirma que sua ética da compaixão permanece condicionada à identificação entre o Eu e o Outro. O presente artigo pretende tratar desta crítica, considerando o problema da alteridade na Ética da Compaixão de Schopenhauer, de modo a rejeitar a ideia de que o fundamento da moral poderia ser compreendido em termos de uma identificação com a alteridade, mas compreendendo-o como uma experiência metafísica de mesmidade do ser. Por fim, pretende-se indicar qual seria propriamente o “lugar” da alteridade na obra de Schopenhauer, bem como apresentar, a partir de sua eudemonologia, os principais elementos da compreensão do autor sobre o tema.
Exploring the potential biomarkers for prognosis of glioblastoma via weighted gene co-expression network analysis
Authors: Zhang Mengyuan , Zhou Zhike , Liu Zhouyang , Liu Fangxi , Zhao Chuansheng 
Published: January 2022

Background
Glioblastoma (GBM) is the most common malignant tumor in the central system with a poor prognosis. Due to the complexity of its molecular mechanism, the recurrence rate and mortality rate of GBM patients are still high. Therefore, there is an urgent need to screen GBM biomarkers to prove the therapeutic effect and improve the prognosis.

Results
We extracted data from GBM patients from the Gene Expression Integration Database (GEO), analyzed differentially expressed genes in GEO and identified key modules by weighted gene co-expression network analysis (WGCNA). GSE145128 data was obtained from the GEO database, and the darkturquoise module was determined to be the most relevant to the GBM prognosis by WGCNA (r = − 0.62, p = 0.01). We performed enrichment analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) to reveal the interaction activity in the selected modules. Then Kaplan-Meier survival curve analysis was used to extract genes closely related to GBM prognosis. We used Kaplan-Meier survival curves to analyze the 139 genes in the darkturquoise module, identified four genes (DARS/GDI2/P4HA2/TRUB1) associated with prognostic GBM. Low expression of DARS/GDI2/TRUB1 and high expression of P4HA2 had a poor prognosis. Finally, we used tumor genome map (TCGA) data, verified the characteristics of hub genes through Co-expression analysis, Drug sensitivity analysis, TIMER database analysis and GSVA analysis. We downloaded the data of GBM from the TCGA database, the results of co-expression analysis showed that DARS/GDI2/P4HA2/TRUB1 could regulate the development of GBM by affecting genes such as CDC73/CDC123/B4GALT1/CUL2. Drug sensitivity analysis showed that genes are involved in many classic Cancer-related pathways including TSC/mTOR, RAS/MAPK.TIMER database analysis showed DARS expression is positively correlated with tumor purity (cor = 0.125, p = 1.07e−02)), P4HA2 expression is negatively correlated with tumor purity (cor =−0.279, p = 6.06e−09). Finally, GSVA analysis found that DARS/GDI2/P4HA2/TRUB1 gene sets are closely related to the occurrence of cancer.

Conclusion
We used two public databases to identify four valuable biomarkers for GBM prognosis, namely DARS/GDI2/P4HA2/TRUB1, which have potential clinical application value and can be used as prognostic markers for GBM.
Association between perceived life stress and subjective well-being among Chinese perimenopausal women: a moderated mediation analysis
Authors: Li Xiangrong , Ren Zheng , Ji Tianliang , Shi Hong , Zhao Hanfang , He Minfu , Fan Xinwen , Guo Xia , Zha Shuang , Qiao Shuyin , Li Yuyu , Pu Yajiao , Liu Hongjian , Zhang Xiumin 
Published: January 2022

Background
The impact of perceived life stress on subjective well-being has been well-established; while few studies have explored the mediating and moderating mechanisms of the association between perceived life stress and subjective well-being among perimenopausal women. This study is aimed at exploring the mediating effect of depressive symptoms and the role of interests/hobbies as a moderator in the association between perceived life stress and subjective well-being among perimenopausal women.

Methods
The participants were 1,104 perimenopausal women at the age of 40 to 60, who were asked to complete a paper-based questionnaire. A single item was used to measure self-perceived life stress and interests/hobbies. The Zung Self-rating Depression Scale (SDS) and Subjective Well-being Scale for Chinese Citizens (SWBS-CC) were applied to assess both depressive symptoms and subjective well-being. Multiple linear regression analysis and the PROCESS macro were adopted to analyse not only the mediating effect of depressive symptoms but also the moderating role of interests/hobbies.

Results
Perceived life stress was negatively associated with subjective well-being (B = − 1.424, β = − 0.101, P < 0.001). The impact of perceived life stress on subjective well-being was partially mediated by depressive symptoms (mediation effect = −0.760, 95% confidence intervals (CI) [−1.129, −0.415]). In addition, the interaction term between depressive symptoms and interests/hobbies was significantly related to subjective well-being (β = − 0.060, P < 0.05), indicating moderating effect. Moderated mediation had a significant index (Index = −0.220, SE = 0.099, 95% CI [−0.460, −0.060]).

Conclusions
Perceived life stress was negatively related to subjective well-being. The impact of perceived life stress on subjective well-being was mediated by depressive symptoms. Besides, interests/hobbies moderated the indirect effect of depressive symptoms on the relationship between perceived life stress and subjective well-being.
Case Report on Ebstein Anomaly
Authors: Ansari Saleha Shahid , Sharma Ranjana 
Published: January 2022

Introduction: Ebstein anomaly, also known as Ebstein malformation, is a congenital (existing at birth) heart defect that affects a small percentage of people. The tricuspid valve (the valve that connects the chambers on the right side of the heart) does not close properly in people with Ebstein abnormality [1].
Patient History: A 25-years female patient was admitted in Acharya Vinoba Bhave Rural Hospital in medicine ward. She was admitted with the complaint of breathlessness on exertion, and weakness since 2 months. patient is a known case of severe ASD since birth. After coming to the ward all investigations done like blood test, ECG, 2D Echo, chest x-ray etc. then final diagnosis is conformed as severe ASD with Ebstein anomaly.
Past History: Patient is a known case of ASD. And not having any other history of communicable disease, asthma, tuberculosis.
Management: Tablet- Lasilactone (20/60)) A diuretic, Tablet- Neurobion Fort, Tablet- Pan 40mg a antacid are prescribed the doctor .
Nursing Management: vital sign checked and documented, comfortable position given as patient having breathing difficulty. Fowlers position given. intake and output of patient recorded. Assessed the patient for anxiety, depression.
Conclusion: Patient was admitted to the hospital with the major complaints of trouble breathing and generalised weakness, and her situation was critical. Immediate treatment was initiated by a member of the health team, and all available treatments were administered, and the patient's condition has improved.
Case Report on Nursing Management of a Client with Peripheral Arterial Disease
Authors: Meshram Vishakha , Tembhare Vaishali , Sawarkar Achita , Shambharkar Madhuri , Raut Arati , Sakharwade Prerana 
Published: January 2022

Peripheral artery disease is a frequent cardiovascular ailment in which constricted arteries restrict blood flow to our limbs. When we have Peripheral Artery Disease in our limbs, our legs haven't had enough flow of blood to increase production. The capillaries that nourish the lower legs narrow and stiffen in peripheral vascular disease, making walking harder. Reduced blood flow can cause cartilage and necrosis in the limbs. Peripheral arterial disease (PAD) is usually caused by multilevel atherosclerotic disease, typically in patients with a history of cigarette smoking, diabetes mellitus, or both. Intermittent claudication (IC), an early manifestation of PAD, commonly leads to reduced quality of life for patients who are limited in their ambulation. Percutaneous intervention for peripheral artery disease has evolved from balloon angioplasty for single lesions. To achieve good long-term efficacy, a close follow-up including objective tests of both the arterial lesion and hemodynamic status, surveillance of secondary preventive measures, and risk factor control.
A 65-year-old man was admitted to the hospital with the following symptoms: worsening left severe calf pain, fatigue, cramping, aching, pain in the legs or arms that worsens when walking or using the arms, tightness in the muscles of the legs that worsens with exercise and improves with rest. He has a diabetes mellitus history. The lower extremity pulse was diminished or absent on physical examination, but all other vital signs were typical. Pulses in the left dorsalispedis and posterior tibialis could not be felt. The results of the cardiac examination were average. The patient has numbness in one leg, pain in both legs, decreased energy in both upper and lower limbs, ulceration, gangrene in the lower extremities, Hair loss, weakness, and dependent rubor (redness caused by swelling) present. He had audible bruits, a nonhealing lower extremity wound, and a delayed capillary refill, so he started treatment as soon as possible.
The primary focus of this study is on professional management and outstanding nursing care, which may provide the holistic care that peripheral arterial disease necessitates while also effectively managing the challenging case.
Comparison of Effect of Phyllanthus emblica (Indian Gooseberry) with and without Honey on Hemoglobin, RBC and PCV among Adolescents
Authors: Kamalli M. , Priyadharshini R. , Sinduja Palati 
Published: January 2022

Introduction: Phyllanthus emblica commonly known by names such as Indian gooseberry, amla belongs to the Phyllanthaceae. The plant is used as a medicine and tonic which is highly nutritious and forms an important dietary source of vitamin C and amino acids. Honey is rich in iron which helps in boosting the hemoglobin content in blood by increasing their synthesis. Complete blood count (CBC) is an array of tests to evaluate the cells in the blood which are the red blood cells, white blood cells, platelets.
Aim: The aim of the study is to compare the effect of Phyllanthus emblica (Indian Gooseberry) with and without honey on hemoglobin, RBC (Red Blood Cell) and PCV (Packed cell volume) among adolescents.
Materials and Methods: Ten adolescents including both male and female were selected as subjects for the study. The first group of subjects were categorised to consume gooseberry alone and the second group of subjects were categorised to consume gooseberry along with honey. After 15 days, CBC was taken for the subjects of both groups to analyse the results. Independent ‘t’ test was applied to evaluate the significance of clinical trials performed in two groups.
Results and Discussion: The participant history included fatigueness, pallor, menstrual history, blood pressure, pulse. There is an increase in the mean value of Hb (Hemoglobin), RBC (Red Blood Cell), HCT (Hematocrit), MCV (Mean corpuscular volume), MCH (Mean corpuscular hemoglobin) and RDW (Red cell distribution width). Independent statistical analysis showed that p value is not significant as all the values are not <0.05.
Conclusion: The present study concludes that gooseberry with honey supplementation has shown better results than gooseberry supplementation but it is not statistically significant. It is evident that gooseberry has nutritive and restorative properties. Daily use of gooseberries is safe and can show more significant increase in counts of RBC, Hb in longer duration.
Comparison of Haemoglobin, RDW, RBC Values among Diabetes Mellitus and Normal Individuals
Authors: Baskar Sharwini , Priyadharshini R. , Sinduja Palati 
Published: January 2022

Introduction: Diabetes mellitus is a disorder characterized by hyperglycemia. It has been reported that 75% of the primary cause for mortality in diabetes mellitus patients is cardiovascular disease which is caused by hyperglycemia. Erythrocytes of diabetes mellitus patients have a shorter life span than normal. Red cell distribution width (RDW) is a measure of the heterogeneity of the volume of red blood cells (Red Blood Cells). High RDW has various adverse outcomes. The study aims to compare Haemoglobin, RDW and RBC values among diabetes mellitus and normal individuals.
Materials and Methods: Blood samples of 20 patients with and without diabetes were collected from outpatients visiting Saveetha dental college and hospitals. The results of the following parameters Haemoglobin, RDW, RBC were analyzed using Independent t Test in SPSS software. The statistical significance (P value) was set at 0.05.
Results: It is evident that there is a higher incidence of diabetes among the male population compared to females which result in higher RBC and Haemoglobin values. The RDW value is also reported to be higher in diabetic patients than non-diabetic patients. For Haemoglobin p value was 0.984 (>0.05), RDW p value was 0.180 (>0.05), RBC p value was 0.680 (>0.05). The p values were >0.05 which is statistically not significant.
Conclusion: The Hemoglobin, RBC and RDW values are higher for diabetic patients than non-diabetic. Higher RDW has various adverse effects such as cardiovascular disease which may cause mortality in diabetes mellitus patients.