bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the AerosolShield in preventing dental droplet spread
Authors: Newsom Richard , Pattison Chris , Lundgren Andrew , Amara Adam , Louca Chris 
Published: December 2022

Abstract

BACKGROUNDThe COVID-19 pandemic has significantly impacted dental healthcare and training. Preventing droplet spread and surface contamination is paramount to keeping patients and practitioners safe. There have been rapid developments in this area and in aerosol reduction.OBJECTIVESTo determine whether the use of an AerosolShield reduced droplet splatter during a dental procedure.METHODSWe performed an assessment of dental splatter, with and without an AerosolShield, a small self-assembling plastic tent. We used fluorescein-stained dental fluid to mark the droplets and captured them on paper targets. We imaged the fluorescent droplet spots under UV light and analysed their size and position using astronomical image analysis techniques.RESULTSThe mean number of spots in the AerosolShield group was 4 spots (SD 7), and 4900 (SD 3100) spots in the control group, a reduction of 99.2% (95% CI 0.99-1.00). The mean area covered of the closest targets was 0.98% (SD 0.43%) for the control (no shield) group, compared with 2.5×10-5% (SD 2.3×10-5%) for the AerosolShield procedures (P < 0.001). The mean maximum distance travelled by the smaller droplets in the control group procedures was 676.3mm (SD 53.9mm), compared with 213.2mm (SD 13.2mm) in the AerosolShield group.CONCLUSIONSThese results show that the AerosolShield reduced the number of droplets detected by 99.2% (95% CI 0.99, 1.0), and the area of target sheets covered in droplets was also reduced by 99.7% (95% CI 0.99, 1.0). We found the AerosolShield a useful method of reducing droplet spread in a dental clinic model. More work on human volunteers and patients would be useful to assess whether the AerosolShield is practical, comfortable, and to confirm that these experimental results are representative.
Cost–utility analysis of a palliative care program in Colombia
Authors: Rodríguez-Campos Luisa , Lesmes Paul Andres Rodríguez , Cancino Analhi Palomino , Diaz Iris Del Valle , Gamboa Luis Fernando , Niuman Andrea Castillo , Bernal Jorge Martínez , Salas Juan Sebastian , Sarmiento Gabriela , González-Vélez Abel 
Published: December 2022

Abstract
Background:The economic assessment of health care models in palliative care promotes their global development. The purpose of the study is to compare the cost–utility ratio of a palliative care program (named Contigo) with that of conventional care from the perspective of a health benefit plan administrator company, Sanitas, in Colombia.
Methods: The incremental cost-effectiveness ratio was estimated using micro-costing in a retrospective, analytical cross-sectional study on the care of terminally ill patients enrolled in a palliative care program. A 6-month time horizon prior to death was used. The EQ-5D-3L questionnaire (EQ-5D-3L) and the McGill Quality of Life Questionnaire (MQOL) were used to measure the quality of life.
Results: The study included 43 patients managed within the program and 16 patients who received conventional medical management. The program was found to be US dollars (USD) 1,789.41 less expensive than conventional practice (P = 0.01). When compared to the last 15 days, there is a higher perception of quality of life, which yielded 0.25 in the EQ-5D-3L (p < 0.01) and 1.55 in the MQOL (P < 0.01). The incremental cost–utility ratio per quality-adjusted life year was USD 290.11.
Conclusion: Because the Contigo program reduces costs while improving quality of life, it is considered to be cost-effective and a model with value in health care. A greater availability of palliative care programs, such as Contigo, in Colombia can help reduce existing gaps in access to universal palliative care health coverage, resulting in more cost-effective care.
Cratylia argentea as a replacement to Tifton 85 hay on finishing lamb diets
Authors: Teixeira ELAINE CRISTINA , Abreu Lucas Freires , de Souza Fernando Antônio , Matrangolo Walter José Rodrigues , Silva Karina Toledo da , de Lima Luciano Soares , de Sa Hemilly Cristina Menezes , Lana Ângela Maria Quintão 
Published: December 2022

Abstract
The objective of this study was to evaluate the performance of finishing Lacaune lambs fed Cratylia argentea hay as an alternative to Tifton 85 (Cynodon spp). Twenty-four Lacaune lambs aged between five and six months (average body weight [BW] 21.50 ± 3.38 kg) were arranged in a split-plot randomized block design. The plots consisted of different Cratylia to Tifton 85 hay proportions (0, 20%, 40%, or 100%, dry matter [DM] basis) as a roughage replacement in the total diet. The subplots represented two evaluation times, entitled “initial period” and “final period”, which consisted of the early seven days of total feces and urine collection, and the last seven days of the experiment, respectively. The lambs were blocked by weight with six replicates per treatment. The results show that the level of Tifton 85 replacement for Cratylia hay in the roughage portion of the lamb diet did not influence (P > 0.05) weight gain (WG), dry matter intake or dry matter digestibility; feed conversion, feed efficiency; and the evaluated nitrogen balance variables. Thus, the alternative legume successfully maintained animal performance of Tifton 85. The digestibility coefficient of neutral detergent fiber decreased linearly as Tifton 85 replacement for Cratylia level was increased, which probably happened due to the presence of highly lignified material within the Cratylia hay. In conclusion, Cratylia hay can be recommended as a feeding strategy for livestock production, especially in regions with unfavorable soil and climate, which requires greater inputs for the production of forage grasses, as Tifton 85.
Model establishment and application of N-substitution pressure fixed point iteration method for indoor fire hydrant system
Authors: Ban Yunxiao 
Published: December 2022

Abstract

The paper presents an noval N-substitution pressure fixed point iteration method under steady-state condition for hydrodynamic calculation of indoor fire hydrant system in building.The modeling bases on introduction the functions of sign,absolute value and maximum value improve intelligence and eliminate illegal computing, application of the Taylor series expansion and linear optimization.And then,according to the principle of numerical calculation,the correction pressure fixed point iteration model was obtained by a natural number N replacing the denominator. In a case, the method combining with MS Excel is applied to hydraulic calculation of building hydrant pipe network system. The results shown that, when N is 10000, only one of the 22 calculated points oscillated around the true value in the early calculation, and converged to the true value in the later calculation.But the calculation errors of the system and the pressure control points converged from beginning to end. The calculation error of the system is twice that of the pressure control point when the calculation errors of all the nodes converge. In the future, N replaces the denominator, which can also provide a reference for the hydrodynamic iterative calculation methods under steady-state condition, such as flow, equivalent flow (building domestic water supply network), temperature (building hot water supply network).
Static and fatigue tensile properties of cross-ply carbon fiber-reinforced epoxy matrix composite laminates with thin ply thickness
Authors: Naito Kimiyoshi , Seki Yuto , Inoue Ryo 
Published: December 2022

Abstract
The static and tensile fatigue properties of cross-ply high-strength polyacrylonitrile (PAN)-based carbon (T800SC) fiber-reinforced epoxy matrix composites (CFRPs) with thin ply thickness were studied. The fiber orientations of the CFRP specimens were set to cross-ply with [0/90]10S (subscript S means symmetry), [(0)5/(90)5]2S, and [(0)10/(90)10]S. The static and tensile fatigue characteristics of cross-ply CFRPs with thick ply thickness with [0/90]2S and [(0)2/(90)2]S were also investigated for comparison. Under static loading, the tensile strength and failure strain of thinnest 90° ply CFRP specimens were higher than those of other 90° ply thickness ones. But, the tensile modulus and Poisson’s ratios were comparable among the cross-ply CFRP with thin and thick ply thickness specimens. Under fatigue loading, the fatigue response of thinnest 90° ply CFRP specimens were higher than those of other 90° ply thickness ones for lower fatigue cycle testing (< 105 cycles). Though, for higher fatigue cycle testing (> 105 cycles), the fatigue responses decreased with a decrease in the 90° ply thickness and the fatigue characteristics of the thinnest 90° ply CFRP specimen were lower than those of other cross-ply CFRP thin and thick ply thickness specimens.
Effect of Traditional Chinese Medicine in patients with COVID-19: A multi-center retrospective cohort study
Authors: Zhao Guozhen , Yan Shiyan , Li Bo , Guo Yuhong , Song Shuang , Hu Yahui , Guo Shiqi , Hu Jing , Du Yuan , Lu Haitian , Ye Haoran , Ren Zhiying , Zhu Lingfei , Xu Xiaolong , Su Rui , Liu Qingquan 
Published: December 2022

Abstract
Background
Traditional Chinese medicine (TCM) has been applied in the treatment of COVID-19 in China, but its effectiveness and safety need evaluation.
Methods
A multi-center retrospective cohort study was carried out, with cumulative TCM treatment period of ≥ 3 days during hospitalization as exposure. Data came from consecutive inpatients in 4 medical centers in Wuhan, China. After data extraction, verification and cleaning, confounding factors were adjusted by inverse probability of treatment weighting, and the Cox proportional hazards regression model was used for statistical analysis.
Results
A total of 2272 COVID-19 patients were included, including 1684 in the TCM group and 588 in the control group. Compared with the control group, the hazard ratio for the deterioration rate in the TCM group was 0.52 [95% CI: (0.41, 0.64), P < 0.001]. The results were consistent across patients of varying severity at admission, and two sensitivity analyses confirmed the robustness of the results. In addition, the hazard ratio for all-cause mortality in the TCM group was 0.29 (95% CI = 0.19–0.44, P < 0.001). For safety, the proportion of patients with abnormal liver function or renal function in the TCM group was smaller.
Conclusion
This real-world study indicates that the addition of a full course of TCM therapy to basic conventional treatment, may reduce the deterioration rate and all-cause mortality of COVID-19 patients with safety. This result can provide evidence to support the current treatment of COVID-19 and new respiratory infectious diseases in the future. Additional prospective clinical trial is needed to evaluate the efficacy and safety of specific TCM interventions.
Trial registration:
ChiCTR, ChiCTR2200062917. Registered 23 August 2022, http://www.chictr.org.cn/showproj.aspx?proj=171556.
Performance of Bemisia tabaci MEAM1 on soybean and resistance traits of cultivars
Authors: Silva Maria Carolina Farias e , Rodrigues Arielly Sousa , Rodrigues Raimundo Henrique Ferreira , Pavan Bruno Ettore , Silva Luciana Barboza 
Published: December 2022

Abstract
This study aimed to evaluate the biological development of Bemisia tabaci MEAM1 confined on eleven soybean cultivars under greenhouse conditions and estimate genetic parameters for correlated resistance traits. Twenty individuals of B. tabaci were released in cages and closed in the petioles of the plant leaflets. A completely randomized design was used with eleven treatments and five replicates. The evaluations occurred over 25 days. The insects that emerged from the bioassay were confined to plants of their respective cultivars. This procedure was performed on five generations of the insect to evaluate the ability of the plant to express resistance by generations of the whitefly. It was found that M 8808 and AS 3810 negatively affected the oviposition of B. tabaci. The cultivar BRS 9280 affected the development of the insect. According to the selection index, the cultivars that showed best performance were BRS 9280, AS 3810, M 8808, and BRS 8383. The cultivars BRS 9280, AS 3810, and M 8808 expressed resistance characteristics for five generations when analyzed under the pressure of whiteflies, which are considered sources of resistance to B. tabaci MEAM1 for breeding programs to obtain resistant cultivars.
A preliminary study on the mechanism of VASH2 in childhood medulloblastoma
Authors: Liu Wen , Fu Yinan , Wang Meng , Zhao Junhong , Chen Julin , Wang Yongxin , Qin Hu 
Published: December 2022

Abstract
Objective: To investigate the difference in VASH2 expression in tumor tissues of different molecular subtypes of pediatric medulloblastoma (MB), to analyze the correlation between VASH2 and molecular subtypes of medulloblastoma, clinicopathological data, and prognosis, and to explore the mechanism of VASH2's role in pediatric medulloblastoma.
Methods: We analyzed 47 pediatric medulloblastoma cases treated in the Department of Pediatric Neurosurgery of the First Affiliated Hospital of Xinjiang Medical University between January 2011 and December 2019, and detected the expression levels of YAP1 and GAB1 in these tumor tissues using immunohistochemistry (IHC), and performed molecular typing (WNT-type, SHH-type, non-WNT-type/SHH-type). To analyze the correlation between VASH2 and molecular subtypes of medulloblastoma. We focused on vasopressor 2 (VASH2) and investigated its biological role in DAOY cell proliferation, apoptosis, migration, invasion, and with the cell cycle by overexpressing and knocking down VASH2 in the medulloblastoma cell line DAOY, respectively, in vitro by small interfering RNA technology.
Results: 1. Among 47 pediatric medulloblastoma cases, 8 were WNT type, 29 were SHH type, and 10 were non-WNT/SHH type. the positive rate of VASH2 was highest in the SHH type with a 68.97% positive rate, followed by non-WNT/SHH and lowest in the WNT type. The results of the multifactorial analysis showed that positive expression of VASH2 was associated with medulloblastoma molecular subtype (SHH type), site of tumor development (four ventricles), and gender (male), P < 0.05.2 The results of cellular experiments showed that overexpression of VASH2 increased the invasion and migration ability of medulloblast Daoy, while knockdown of VASH2 inhibited the invasion and Overexpression of VASH2 upregulated the expression of Smad2+3, Smad4, Mmp2 and the apoptotic indicators Bcl-2 and Caspase3, while knockdown of VASH2 suppressed the expression of Smad2+3 and Mmp2, and silenced the expression of Smad4 and the apoptotic indicators Bcl2, Caspase3 expression. Flow cytometric cycle analysis showed that VASH2 overexpression increased the S phase in the Daoy cell cycle, while VASH2 knockdown decreased the S phase in the Daoy cell cycle.
Conclusion: We found for the first time that the positive expression rate of VASH2 was closely associated with SHH-type pediatric medulloblastoma, and VASH2 was involved in the invasion, migration, cell cycle, and apoptotic ability of the medulloblast cell line DAOY by affecting downstream indicators of the TGF-β pathway. It is suggested that it is involved in the progression of childhood medulloblastoma, and VASH2 is expected to be a diagnostic and therapeutic target for SHH-type childhood medulloblastoma.
The 3rd July 2019 paroxysm at Stromboli: insights into volcanic ballistics dispersion
Authors: Bisson M. , Spinetti C. , Gianardi R. , Strehlow K. , De Beni E. , Landi P. 
Published: December 2022

Abstract

High resolution dispersion of the ballistic projectiles erupted at Stromboli (Aeolian Archipelago, Italy) during the early phase of the 3rd July 2019 paroxysm was digitally reproduced and analysed. The paroxysms punctuate the persistent mild-explosive activity of Stromboli producing fallout of ballistic juvenile and lithic bombs that represent a serious threat for tourists climbing the volcano and for people living in the island. Drone images, acquired within a few days after the first 2019 paroxysm, were elaborated on GIS environment to identify and reproduce, as geo-spatial features, the ballistic spatter clasts emplaced on the volcano. The results indicate that 152,228 scattered spatter clasts, whose dimensions range from 0.03 m2(16 cm x 16 cm) to 4.23 m2(~ 2 x 2 m), were emitted on the east flank during the paroxysm. Such spatters represent the scattered clasts dispersed on 0.407 km2, and cover a total area of 29,000 m2corresponding to an erupted products volume of 6–7*103m3, calculated here for the first time. Further spatial and fitting analyses on spatter clasts distribution reveal the main dispersion trends of the ballistics, highlighting as the terrain morphology can influence the dynamic of the clasts emplacement.
Factors associated to patients’ referral to private Covid-19 healthcare centers in Tabriz, Iran
Authors: Jafari Nasrin , Akbari Hossein , Sarbakhsh Parvin , Dorosti Abbasali , Khayatzadeh Simin , Mohammadpoorasl Asghar 
Published: December 2022

Abstract

BackgroundIn Iran, tracking of patients and its associated data recording in private healthcare centers are poor, and thus a majority of patients suffering from Covid-19 are treated without any control on the isolation and quarantine processes. The present study aims to investigate the factors contributed to referral to private healthcare centers that provide Covid-19 care services.MethodsThis cross-sectional study was conducted from November 2021 to January 2022 in Tabriz, Iran. We invited a total of 258 and 202 Covid-19 patients from governmental and private healthcare centers, respectively, to participate in the study. Applying a self-administered questionnaire, we collected data on the reason of referring to the healthcare centers, patient’s waiting time, quality of healthcare services received by the patients, patients’ level of satisfaction, accessibility, insurance coverage, perceived severity of the disease, and the level of staff compliance from health protocols. Logistic regression model was used for data analysis.ResultsAdjusted for other variables, higher socio-economic status (OR=7.5), older age (OR=1.02), referral of friends and family members (OR=1.93), shorter waiting time (OR=1.02) and higher satisfaction (OR=1.03) were contributed to referral to private centers. Better accessibility (OR=0.98) and wider insurance coverage (OR=0.98) were also contributed to referral to governmental centers.ConclusionOlder age, higher socio-economic status, lower levels of waiting times for service provision, and higher levels of patient satisfaction were identified as determinant factors for patients’ referral to private healthcare centers. On the other hand, higher levels of accessibility to governmental healthcare centers and wider health insurance coverage reduced the possibility of referring to the private centers.
Identification of Hotspots in Synthetic Peptide Inhibitors of the FOXO4:p53 Interaction
Authors: Zhang Ran , Gao Kai , Sadremomtaz Afsaneh , Ruiz-Moreno Angel J. , Monti Alessandra , Al-Dahmani Zayana M. , Gyau Ben , Doti Nunzianna , Groves Matthew R. 
Published: December 2022

Abstract
Background:
Many stresses trigger cellular senescence, including telomere shortening, oncogene activation, DNA-replication stress, oxidative stress, and resistance to apoptosis. Forkhead box protein O4 (FOXO4) plays a pivotal role in cellular senescence, by binding to and inactivating p53, thereby leading to cellular senescence and inhibiting p53 mediated apoptosis. As a result, misregulation of FOXO4-p53 is linked to numerous diseases including cancers and aging-related diseases, pulmonary fibrosis and neurodegenerative diseases. Targeting of the FOXO4-p53 interface has been accomplished using a synthetic D retro inverse peptide (DRI), however recognition of the key molecular drivers of the interactions remains unknown. Understanding these interactions on a molecular level could lead to the development of small compounds, with enhanced pharmacological qualities, such as high stability, membrane permeability, and oral bioavailability, that mimics the activity of the DRI peptide.
Methods and Results:
Using an in silico model of the FOXO4-p53 interaction, we designed shorter peptides within the DRI to identify the key interactions. A biophysical assay demonstrates these shorter peptides retain strong binding affinity to p53, suggesting that the DRI's hot spot is located within these peptides.
Conclusions:
Taken together, this data provides information at the molecular level that is key to understanding the interplay of two proteins responsible for cellular senescence and provides the basis for the design of small molecules to inhibit this interaction.
Targeted inhibition of CD47 expression in Human cancer cell lines on treatment with Cardiac Glycosides
Authors: Kumavath Ranjith , Pavithran Honey 
Published: December 2022

Abstract
The interest has grown in therapeutically targeting Hypoxia-inducible factor 1α (HIFα), which directly stimulates the expression of cluster of differentiation 47 (CD47) on the cell surface that suppresses phagocytosis in cancer cells. Increased expressions of CD47 and counter interaction with signal regulatory protein alpha (SIRPα) enable cancer cells to avoid cell-mediated cell destruction. On the other side, decreased expression of SIRPα was reported to promote growth. Thus, colossal concern and curiosity arise in identifying the molecular mechanism behind this suppressive effect of CGs in controlling cancer cells. We first report that cardiac glycosides (CGs) inhibit HIFα and CD47 in human breast, lung, and liver cancer cells. Furthermore, our analysis through TCGA (The Cancer Genome Atlas) data shows that these three potential genes correlate with poor survival in breast, lung, and liver cancers. Our molecular docking and molecular dynamic simulations studies demonstrated the interaction of the mentioned CGs with target proteins and identified the stability. Importantly, unlike any other anti-CD47 antibodies, the antitumor activity of CGs has been evaluated in many cancers with no hematologic toxicities. These findings would help to develop clear strategies to target CD47 and SIRPα interaction through HIF1-α inhibitors to promote phagocytosis.