bluuebunny/crossref_metadata_2025_split huggingface dataset:
Library of the Jesuit College in Lviv and Its Fate after the Dissolution of the Society of Jesus
Authors: Loshtyn Nazarii 
Published: September 2022

The Library of the Jesuit college in Lviv is known as the biggest and best-equipped library in the city. It was founded at the beginning of the 17th century, and after one hundred years, there were approximately 12,000 books. But there was a huge loss of books after a great fire in 1734. After that Jesuits restored their book collection. Historiography says that there were approximately 10,000 books in the library at the time of the dissolution of the Society of Jesus.
Unfortunately, it is impossible to verify the information about 10,000 books because historians still cannot find an old catalogue of the library. In the article, the author analyzes manuscript III 12719 from the National Library in Warsaw. The author proves that this manuscript is the catalogue of the library of the Jesuit college in Lviv. This catalogue was created in 1774, after the dissolution of the Jesuits. Its author was a former Jesuit monk, Stanisław Chmielowski, who was assigned by Austrian authority to create catalogues of the libraries of the abolished Jesuit colleges. According to this catalogue, the Jesuit library consisted not of 10,000 books but of 5,000. It corresponds to the information from Ludwik Grzebień, the author of the best known research about the Jesuit libraries in the Polish-Lithuanian Commonwealth.
After 1713, the Jesuit library in Lviv was still functioning. Due to the order of Vienna’s authority, the Jesuit library was turned into a public library. It was the first public library in the city. At the same time, the library arranged an educational process in schools in the city. As stated by inscriptions in the catalogue, teachers, clergy, and civil servants were the readers of the library. In 1784, the former Jesuit library became a part of the Lviv University Library.
Left Atrium Involvement in Lymphoma Patients: Single Center Observational Study
Authors: Salakheeva E. Yu. , Sokolova I. Ya. , Lyapidevskaya O. V. , Zhbanov K. A. , Tsatsurova S. A. , Kanevskiy N. I. , Stebakova V. O. , Privalova E. V. , Ilgisonis I. S. , Belenkov Yu. N. , Shchendrygina A. A. 
Published: September 2022

Aim. To assess the structure and performance of left atrium (LA) before and after 3 cycles of anticancer treatment in lymphoma patients, as well as the incidences of supraventricular arrhythmia (SVA) and the levels of biomarkers of inflammation.Material and Methods. This is a prospective observational study of patients with confirmed diagnosis of lymphoma [n=23; 57% men; median age 52 (34;64) years], who had no prior polychemotherapy. The comparison group included persons without lymphoma [n=18; 50% men; median age 43 (37; 54) years] comparable with the main group in terms of sex, age and risk factors for cardiovascular diseases. Patients with lymphoma underwent 24h-ECG monitoring and advanced transthoracic echocardiography at baseline and after 3 cycles (within 3 months) of anticancer treatment. Biomarkers of inflammation were measured. The results were compared with the data of the comparison group.Results. In lymphoma patients, LA reservoir, conduit, and booster function were found to be impaired at baseline but were comparable with these in matched controls. After 3 cycles of anticancer treatment, a trend to reduction of LA booster and conduit strain was found. The proportion of those with SVA was significantly higher in lymphoma patients before chemotherapy compared to those after anti-cancer treatment or controls: 57% vs 10% and 33% respectively (p<0.05). Lymphoma patients had a higher number of premature ventricular beats at baseline than after treatment or in control [183 (14;841) vs 38 (14;94) and 9 (4;38) respectively]. There were no associations found between the parameters of LA structure and function and SVA. Moderate positive correlation between ESR and supraventricular premature complexes was found (rS=0.44; p<0.05). A positive correlation between LA contractile function and inflammatory biomarkers were revealed: LA active ejection fraction (LA EFact) and ESR (rS=0.42, p<0.05); LA volume index and β-globulin (rS=0.43, p<0.05); LA EFact and neuregulin-1β (rS=0.42, p<0.05); LA expansion index and neuregulin-1β (rS=0.55, p<0.05).Conclusions. In lymphoma patients, LA phasic strain parameters were impaired regardless of anticancer treatment. The associations between inflammatory biomarkers with SVA and parameters of LA performance were found.
N-acetylcysteine in the Prevention of Contrast-induced Acute Kidney Injury: a Systematic Review and Meta-analysis of Randomized Controlled Clinical Trials
Authors: Mezhonov E. M. , Vyalkina Yu. A. , Shalaev S. V. 
Published: September 2022

Aim. To analyze the currently available published randomized controlled clinical trials to evaluate the effect of N-acetylcysteine on the incidence of contrast-induced acute kidney injury (CI-AKI).Material and methods. The meta-analysis was performed in accordance with the PRISMA guidelines based on a search of existing literature in the PubMed/MEDLINE database for the period from 2015 to 16 February 2022. Keywords included MeSH terms «acute kidney injury» or «contrast-induced nephropathy» or «AKI» or «CIN» and «contrast media» and «N-acetylcysteine». The RoB 2 tool was used to assess study bias.Results: When searching based on the initially selected statistics, 98 publications were identified, some of them were excluded from the analysis due to non-compliance with the inclusion criteria in this meta-analysis, 7 studies of unused sources of detection were ultimately selected, the total number of patients in the discovery was 10394.The results of the meta-analysis revealed that in patients treated with N-acetylcysteine CI-AKI developed with the same frequency as in patients who did not observe such therapy as a prophylaxis for this disease (odds ratio 1.06, 95% confidence interval 0.911.23, p=0.46).Conclusion. The use of N-acytelcysteine does not offer any advantage in reducing the incidence of CI-AKI compared with the administration of saline solutions (sodium bicarbonate or sodium chloride 0.9%) or placebo.
Detection and Treatment of Hyperuricemia in Clinical Practice (According to the PROFILE Outpatient Registry)
Authors: Kutishenko N. P. , Martsevich S. Yu. , Zagrebelnyy A. V. , Lukina Yu. V. , Voronina V. P. , Dmitrieva N. A. , Lerman O. V. , Tolpygina S. N. , Blagodatskikh S. V. , Budaeva I. V. , Nekoshnova E. S. , Drapkina O. M. 
Published: September 2022

Aim. To study the frequency of detection of hyperuricemia (HU) in patients with high and very high cardiovascular risk and the frequency of prescribing drugs that lower serum uric acid (sUA) levels in real clinical practice.Material and methods: The general information of the study was based on the data of 2457 patients who were consistently included in the «PROFILE» registry until November 30, 2020: 1250 men (50.9%) and 1207 (49.1%) women. All patients with HU were selected (UA level ≥360 pmol/l in women, ≥420 pmol/l in men). At the stage of inclusion of the patient, data on MC indicators were available in 1777 (72.3%), upon re-examination - only 262 (33.2%) out of 790 patients who returned to the appointment.Results: The most common study of the level of sUA was performed in patients with gout (65.2%), with arterial hypertension (AH) and dyslipemia in 29.1% of cases, with diabetes mellitus (DM) - 30.1%, with impaired tolerance to glucose (IGT) - 40.2%, with other diseases, the proportion of patients with a known UA was even less. A positive relationship was found between the presence of AH and IGT with the frequency of UA control (p<0.001). In patients with AH, an increase in the level of sUA was detected significantly more often than in patients without AH (p<0.001), and less frequently in patients with DM and IGT (p<0.001 and p<0.01, respectively). The frequency of allopurinol prescribing was low: 49 (2%) patients received therapy, while of the 284 patients with HU, only 20 (7%) were prescribed allopurinol.Conclusion: in real clinical practice, only 29.1% of patients with AH and 20-25% of patients with other CVDs were monitored for sUA levels, every third patient had data on sUA levels at a repeat visit. In the presence of gout, the proportion of patients with current UA was higher (65%). For those with AH and IGT, positive correlations were found between the presence of the disease and control of sUA levels. A low frequency of prescribing drugs for the correction of HU was revealed.
Design of Pitcher Shape Circularly Polarized Flexible Antenna for C-Band Applications
Authors: Agarwal Raghav , Saxena Anurag 
Published: September 2022

Abstract
A Pitcher shape circularly polarized flexible antenna for use in C-Band (4–8 GHz) applications is presented. According to IEEE Frequency spectrum, the C-Band has wavelength of 7.5–3.75 cm. The wearable antenna was shaped on leather texture (as substrate) and it is simple in design. The presented design includes a circle-shaped scorching patch with a defected ground. The microstrip linefeed procedure is utilized to energize the antenna. The impedance bandwidth of the proposed antenna is observed to be very less i.e. 20.35%, between 6 and 7.36 GHz but the return loss at 6.704 GHz resonant frequency is quite impressive and measured as -30 dBi. The impact of the radio antenna boundaries is likewise dissected through a parametric report. To check the activity of the introduced plan, the antenna apparatus was manufactured and tried utilizing a vector network analyzer. Examination of the recreated and estimated results uncovered great understanding.
Associations of psychological capital, coping style and emotional intelligence with self-rated health status of college students in China during COVID-19 pandemic
Authors: Jing Xiangzhi , Meng Hongling , Li Yuping , Lu Lingeng , yao yongcheng 
Published: September 2022

Abstract
Background COVID-19 lockdown can lead to mental health problem, and the problem is heterogeneous across individuals. In this study, we aimed to explore the association between the self-reported health status, emotional coping style, emotional intelligence and positive psychological state of college students during the COVID-19 pandemic in China.
Methods The questionnaires of Self-rated Health Measurement Scale (SRHMS), Emotional Intelligence Scale (EIS), Psychological Capital Questionnaire (PCQ), Simplified Coping Style Questionnaire (SCSQ）were used for online survey. The study included 367 undergraduates.
Results Undergraduate sex, sibling and birth of place were associated with either psychological capital scores, or/and emotional intelligence. Online time per day had significantly negative associations with self-rated health and psychological capital scores. Multivariate analysis showed that the interaction between emotional intelligence, psychological capital and coping styles was statistically significant (β = -0.112，p =0.045) in health status with psychological capital ranking the top (β = 0.428). Mediation analysis showed that psychological capital and coping style modified the effect of emotional intelligence on health status.
Conclusions: Psychological capital and coping style modified the effect of emotional intelligence on health status in college students during the COVID-19 pandemic. In this pandemic emergency, a comprehensive intervention, such as positive coping styles with optimistic emotional perception and understanding as well as social support, is an important measure against the pandemic-induced mental health problem in college students in China.
Evaluation of the 5-HT2C receptor drugs RO 60-0175, WAY 161503 and mirtazepine in a preclinical model of comorbidity of cocaine addiction and depression
Authors: Jastrzębska Joanna , Frankowska Małgorzata , Smaga Irena , Hubalewska-Mazgaj Magdalena , Suder Agata , Pieniążek Renata , Przegaliński Edmund , Filip Małgorzata 
Published: September 2022

Abstract
Epidemiological data indicate a high rate of comorbidity of depression and cocaine use disorder (CUD). The role of 5-HT2C receptors in the mechanisms responsible for the coexistence of CUD and depression has not been investigated. Here, we combined bilateral olfactory bulbectomy (OBX), an animal model of depression, with intravenous cocaine self-administration and extinction/reinstatement in male rats to investigate two 5-HT2C receptor agonists (Ro 60–0175 (RO) and WAY 161503 (WAY)) and the 5-HT2C-receptor preferring antagonist mirtazapine (MIR; an antidepressant), with the goal of determining whether these drugs alter cocaine-induced reinforcement and seeking behaviors. Additionally, neurochemical analyses following cocaine self-administration and its abstinence period in the brain structures in OBX rats and SHAM-operated controls were performed. Acute administration of RO reduced, while WAY non-significantly attenuated cocaine reinforcement in OBX and SHAM rats. Moreover, RO or WAY protected against cocaine-seeking behavior after acute repeated drug administration during extinction training in OBX and SHAM rats. By contrast, acutely administered MIR did not alter cocaine reinforcement in both rat phenotypes, while acute (but not repeated) pretreatment reduced cocaine seeking in OBX and SHAM rats. In neurochemical analyses, cocaine reinforcement increased 5-HT2C receptor levels in the ventral hippocampus; this effect was enhanced by preexisting depression-like phenotype. The 10-daily cocaine abstinence from self-administration reduced 5-HT2C receptor expression in the dorsolateral striatum but coexistence of depression and CUD enhanced local receptor expression. The present study supports further development of pharmacological strategies with drugs targeting the 5-HT2C receptor for the treatment of comorbid depression and CUD.
GlPS1 overexpression accumulates coumarin secondary metabolites in transgenic Arabidopsis
Authors: Ren Hongwei , Yu Yanchong , Xu Yao , Zhang Xinfang , Tian Xuemei , Gao Ting 
Published: September 2022

Abstract
The dried root of Glehnia littoralis is a traditional Chinese herbal medicine mainly used to treat lung diseases and plays an important role in fighting coronavirus disease 2019 pneumonia in China. This study focused on the key enzyme gene GlPS1 for furanocoumarin synthesis in G. littoralis. In the 35S:GlPS1 transgenic Arabidopsis study, the Arabidopsis thaliana-overexpressing GlPS1 gene was more salt-tolerant than Arabidopsis in the blank group. Metabolomics analysis showed 30 differential metabolites in Arabidopsis, which overexpressed the GlPS1 gene. Twelve coumarin compounds were significantly upregulated, and six of these coumarin compounds were not detected in the blank group. Among these differential coumarin metabolites, isopimpinellin and aesculetin have been annotated by the Kyoto Encyclopedia of Genes and Genomes and isopimpinellin was not detected in the blank group. Through structural comparison, imperatorin was formed by dehydration and condensation of zanthotoxol and a molecule of isoprenol, and the difference between them was only one isoprene. Results showed that the GlPS1 gene positively regulated the synthesis of coumarin metabolites in A. thaliana and at the same time improved the salt tolerance of A. thaliana.
Alleviation of drought stress in soybean by applying of biostimulant based on amino acids and macro- and micronutrients
Authors: Repke Rodrigo Alberto , Silva Dayane Mércia Ribeiro , Santos Jania Claudia Camilo dos , Silva Marcelo de Almeida 
Published: September 2022

Abstract

Drought stress is one of the most predominant environmental factors hindering the soybean productivity. This study investigated the effects of an exogenous application of biostimulants, consisting of nitrogen, phosphorous, iron, copper, boron, manganese, zinc and amino acids, in the physiological, biochemical and productive responses of soybean cultivated under drought stress. Findings showed that applying 0.5 kg ha− 1 of the biostimulant improved soybean tolerance to drought. The biostimulant application maintained the leaf photosynthetic rate (A), stomatal conductance (gs), transpiration rate (E), leaf temperature, water use efficiency (WUE) and carboxylation efficiency (CE), in addition to increasing the SPAD index. Moreover, the biostimulant heightened the activity of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and ascorbate peroxidase (APX) and maintained the activity of the nitrate reductase enzyme. Regarding osmoprotectant, the biostimulant application enhanced proline accumulation, which could improve the soybean’s osmotic adjustment under drought conditions. In addition, foliar application of the biostimulant maintained the biometric and production characteristics, stem diameters, number of branches, number of pods with 1, 2 and 3 grains, and significantly increased leaf area, number of primary stem nodes, dry matter mass in the aerial part and roots, ultimately increasing yield. Based on the aforementioned beneficial properties, the biostimulant based on macro- and micronutrients and amino acids, particularly in the dose 0.5 kg ha− 1, has proven to effectively relieve the adverse effects of drought stress in soybean.
Predicting Hospital Admission among High Acuity Triaged Patients Transported to the Emergency Department in Ontario, Canada: A Population-Based Cohort Study using Machine Learning
Authors: Strum Ryan P , Mowbray Fabrice I , Zargoush Manaf , Jones Aaron 
Published: September 2022

Abstract
Background
Paramedics are mandated to transport emergently triaged patients to the closest emergency department (ED). The closest ED may not be the optimal transport destination if further distanced ED’s can provide specialized care or are less crowded. Machine learning may support paramedic decision-making to transport a specific subgroup of emergently triaged patients that are unlikely to require hospital admission or emergency care to a more appropriate ED. We examined whether prehospital patient characteristics known to paramedics were predictive of hospital admission.
Methods
We conducted a retrospective cohort study using machine learning algorithms to analyze ED visits of the National Ambulatory Care Reporting System from Jan 1, 2018 to Dec 31, 2019 in Ontario, Canada. We included all adult (≥ 18 years) paramedic transports to the ED who had an emergent Canadian Triage Acuity Scale score (CTAS 2). Eight prehospital characteristic classes known to paramedics were used. We applied four machine learning algorithms that were trained and assessed using 10-fold cross-validation to predict the ED visit disposition of admission to hospital or discharged from ED. Predictive model performance was determined using the area under the receiving operating characteristic curve (AUC) with 95% confidence intervals and probabilistic accuracy using the Brier Scaled score. Variable importance scores were computed to determine the top 10 predictors of hospital admission. We also reported sensitivity, specificity, and positive and negative predictive values to support performance interpretation.
Results
All machine learning algorithms performed similarly for the prediction of which ED patient visits would be admitted to hospital (AUC 0.77–0.78, Brier Scaled 0.22–0.24). The characteristics most predictive of admission included age 65 to 105 years, referral source from a residential care facility, presenting with a respiratory complaint, and receiving home care.
Conclusions
Machine learning algorithms performed well in predicting ED visit dispositions using a comprehensive list of prehospital patient characteristics. To the best of our knowledge, this study is the first to utilize machine learning to predict ED visit outcomes from patient characteristics known prior to paramedic transport. This study has potential to inform paramedic regulations regarding the distribution of emergently triaged patients.
GWAS and Genomic Prediction for Pre-harvest Sprouting Tolerance in Spring Wheat
Authors: Kumar Manoj , Kumar Sachin , Sandhu Karansher Singh , Kumar Neeraj , Saripalli Gautam , Prakash Ram , Nambardar Akash , Sharma Hemant , Gautam Tinku , Balyan Harindra Singh , Gupta Pushpendra Kumar 
Published: September 2022

Abstract
In wheat, a genome-wide association study (GWAS) combined with a study of genomic prediction (GP) was conducted for pre-harvest sprouting tolerance (PHST). For GWAS, a panel of 190 accessions was phenotyped for the three parameters of PHST (sprouting score, falling number and grain color) over two years and genotyped with 9,904 DArT-seq SNP markers. GWAS for main-effect quantitative trait nucleotides (M-QTNs) was performed using the following three models: CMLM, SUPER, and FarmCPU. A total of 171 M-QTNs (CMLM, 47; SUPER, 70; FarmCPU, 54) were detected, suggesting differences in efficiencies of the three models. As many as 15 epistatic QTNs (E-QTNs) involved in 20 first order epistatic interactions were also identified using PLINK v1.07. A total of 26 PHS-responsive genomic regions (each 5 Mbp in size) that spread over 16 chromosomes were demarcated, which overlapped the previously mapped QTLs, MTAs, cloned genes and the M-QTNs reported in the present study. As many as 20 definitive and stable QTNs were recommended for use in marker-assisted recurrent selection (MARS) for improvement of PHST. Candidate genes associated with different M-QTNs revealed key role of some QTNs in abscisic acid pathway involved in PHST. Genomic prediction accuracies (based on cross-validation approach) using three different models ranged from 0.41 to 055, which are comparable to the results of previous studies. In summary, the results of the present study improved our understanding of the genetic architecture of PHST in wheat and provided novel genomic resources for wheat breeding based on MARS and GP.
Student Survey After Ten Years of Continuous Blended Teaching of Echocardiocraphy
Authors: Parra Víctor M. , Fita Guillermina , Azqueta Manel , González Mauricio , Aranda Fernando , Maestre MaLuz , Silva Jorge , Hortal Javier , Morales Daniel , Bórquez Emiliano , Adasme Fabián , Real María Isabel , Mercadal Jordi , Zelada Pamela , Riobó Gonzalo , Galdames Katia , Domenech Raúl J. 
Published: September 2022

Abstract

Aims: The aim of this study is to analyze the impact of 10 years of blended learning in echocardiography.
Methods and results: A total of 140 of 210 medical doctors who graduated from our teaching program from 2011 to 2020 responded to the survey. Among them, 53,57% were anesthesiologists and 26,42% intensivists. More than 85% of respondents indicated that the online period met their expectations, and 70,2% that the hands on practice met the objectives. Posterior to the Diploma there was a significant increase in the frequency of use of echo compared to before the Diploma, both in transthoracic and transesophageal echocardiography, from 24,29% to 40,71% and from 13,57% to 27,86%, respectively. The echo was applied mainly in the perioperative period (56,7%) and in intensive care (32,3%), and only in 11% of cases it was used in emergency units. Additionally, 92,4% of respondents revealed that it was very useful in their subsequent professional practice and 92,47% that it helped them in the interpretation of echo reports.
Among the strengths they highlighted ‘the theoretical content, clinical cases, hands on activity and the teaching staff’. Among the weaknesses, 50% requested a practice period lasting more than one week.
Conclusion: The blended learning of echocardiography over a decade has been satisfactorily evaluated by the graduated specialists and has been related to a significant increase in its use in the perioperative period and in intensive care. The main challenges are to establish a longer period of practice and achieve greater scope in Emergency Medicine.