bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jian-Pi-Yi-Shen Formula Improves Adenine-Induced Chronic Kidney Disease via Regulating Tryptophan Metabolism and Aryl Hydrocarbon Receptor Signaling
Authors: Liu Xinhui , Deng Ruyu , Chen Yulian , Huang Shiying , Lu Jiandong , Zheng Lin , Xiong Guoliang , Li Shunmin 
Published: July 2022

Traditional Chinese medicine (TCM) is an important complementary and alternative branch of chronic kidney disease (CKD) therapy. Jian-Pi-Yi-Shen formula (JPYSF) is a TCM formula used for treating CKD with good efficacy. However, the underlying mechanisms of JPYSF in treating CKD remain to be elucidated. The purpose of the present study was to investigate the renoprotective effect and potential mechanism of JPYSF in treating CKD. CKD rat model was induced by feeding a diet containing 0.75% w/w adenine for 4 weeks. JPYSF was given by gavage every day, starting from the 3rd week of the adenine-containing diet and continuing for 4 weeks at the dose of 10.89 g/kg. Renal injury was evaluated by serum creatinine (Scr), blood urea nitrogen (BUN), histopathology, and fibrotic markers expression. Serum levels of tryptophan metabolites were detected by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Aryl hydrocarbon receptor (AHR) signaling was tested by Western blot analysis. The results found that JPYSF treatment significantly lowered Scr and BUN levels, improved renal pathological injury, and down-regulated fibrotic markers expression in CKD rats. Furthermore, JPYSF significantly reduced the levels of 10 tryptophan metabolites in the serum of CKD rats and restored the level of tryptophan. Additionally, the kidney expression of AHR signaling was enhanced in CKD rats and was further suppressed in JPYSF treated rats. These results suggested that JPYSF protected against adenine-induced CKD via modulating tryptophan metabolism and AHR activation.
Network-Based Pharmacological Study on the Mechanism of Guishao-Liujun Decoction in the Treatment of Gastric Cancer
Authors: Qian Xiaoqing , Zhang Lingle , Xie Feng , Cheng Yingsheng , Cui Daxiang 
Published: July 2022

Objective: The aim of the study was to use a network pharmacological method to examine the mechanism of Guishao-Liujun decoction against gastric cancer (GC).Methods: The traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) and the Traditional Chinese Medicine Integrated Database (TCMID) were used to obtain the chemical composition and targets of all the drugs of Guishao-Liujun decoction, and the targets of GC were screened using GeneCards and Online Mendelian Inheritance in Man (OMIM) databases. The obtained targets were imported into Cytoscape 3.7.2 software by using the R language to take the intersection for a Venn analysis to construct active ingredient target networks, and they were imported into the STRING database to construct protein–protein interaction (PPI) networks, with the BisoGenet plugin in Cytoscape 3.7.2 being used for analyzing network topology. On the potential target of Guishao-Liujun decoction for GC, gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed using the R-language bioconductor platform, and the outcomes were imported into Cytoscape 3.7.2 software to obtain the KEGG network map. The core targets were docked with the active components by the macromolecular docking software application AutoDock Vina.Results: A total of 243 chemical components and 1,448 disease targets including 127 intersecting targets were discovered. AKT1, TP53, and GO functional analysis were mainly associated with ubiquitination and oxidase reduction activity. In GC treatment, the KEGG analysis revealed that Guishao-Liujun decoction mainly acted through the tumor necrosis factor (TNF), interleukin 17 (IL-17), and cancer-related signaling pathways, with the best binding performance with TP53, as indicated by the outcomes of macromolecular docking.Conclusion: In the treatment of GC, Guishao-Liujun decoction works with a variety of components and targets, establishing the groundwork for further research into its mechanism of action.
Rumex japonicus Houtt. Extract Suppresses Colitis-Associated Colorectal Cancer by Regulating Inflammation and Tight-Junction Integrity in Mice
Authors: Kim Hee-Young , Seo Ji Eun , Lee Hanul , Bae Chang-Hwan , Ha Ki-Tae , Kim Seungtae 
Published: July 2022

Irritable bowel disease (IBD), which results in an elevated risk of colitis-associated colorectal cancer (CAC), is characterized by inflammation and barrier disruption of the gut. The genus Rumex has anti-oxidative and anti-inflammatory effects, and the roots of Rumex japonicus Houtt (RJ) have been traditionally used in East Asia to treat digestive problems. We investigated the protective effect of RJ against azoxymethane (AOM)-and dextran sulfate sodium (DSS)-induced CAC in C57BL/6N male mice. The mice were intraperitoneally injected with AOM on the first day and orally treated with 2% DSS for 2 weeks (on the third and sixth weeks). RJ extract (100 mg/kg) was administered to the mice in the RJ group for 4 weeks (from the third to sixth week), and all mice were sacrificed on the final day of the eighth week. Changes in morphology, tight junctions (TJs), inflammation-related factors in the colon and serum inflammatory cytokine levels were measured. The colons of AOM/DSS-treated mice were shorter and heavier than those of normal mice. The number of tumors in the colons of AOM/DSS-treated mice increased; however, RJ suppressed these changes. RJ also reduced the levels of tumor necrosis factor-α, interleukin (IL)-6, and IL-1β in the colon and serum, and it increased the level of IL-10 in the colon. Moreover, RJ inhibited the barrier disruption and apoptosis in the colons of AOM/DSS-treated mice. RJ effectively suppressed AOM/DSS-induced CAC by inhibiting tumor formation, inflammation, disruption of TJ, and apoptosis in the colon.
Theta-Burst Stimulation Combined With Virtual-Reality Reconsolidation Intervention for Methamphetamine Use Disorder: Study Protocol for a Randomized-Controlled Trial
Authors: Wen Yatong , Hao Xuemin , Chen Xijing , Qiao Siyue , Li Qianling , Winkler Markus H. , Wang Fenglan , Yan Xiaoli , Wang Fang , Wang Liang , Jiang Feng , Pauli Paul , Dong Xinwen , Li Yonghui 
Published: July 2022

BackgroundCraving associated with drug-related memory is one of the key factors that induce the relapse of methamphetamine (MA). Disruption or modulation of the reconsolidation of drug-related memory may serve as an option for clinical treatment of MA addiction. This protocol proposes to use virtual reality (VR) to retrieve drug-associated memory and then use transcranial magnetic stimulation (TMS) at the neural circuit that encodes the reward value of drug cues to provide a non-invasive intervention during reconsolidation. We aim to evaluate the effectiveness of TMS treatment after VR retrieval on the reduction of cue reactivity and craving of MA.MethodsThis is a randomized, double-blind, sham-controlled, parallel group trial, targeting participants with MA use disorder aged from 18 to 45 years old. Forty-five eligible volunteers in Shanxi Drug Rehabilitation Center will be recruited and be randomly allocated into three parallel groups, receiving either 1) MA-related cues retrieval in VR combined with active TMS (MA VR scene + TBS) or 2) sham TMS (MA VR scene + sham TBS), or 3) neutral cues retrieval in VR combined with active TMS (neutral VR scene + TBS). Two sessions of post-VR-retrieval TBS will be scheduled on two separate days within 1 week. The primary outcome will detect the memory-related activity by the electroencephalography (EEG) reactivity to drug cues in VR scenes. Secondary outcomes are the self-reported MA craving in VR scene, the physiological parameter (cue-induced heart rate) and the scores of psychological questionnaires including anxiety, depression, and mood. All primary and secondary outcomes will be assessed at baseline, 1-week, and 1-month post-intervention. Assessments will be compared between the groups of 1) MA VR scene + TBS, 2) MA VR scene + sham TBS and 3) neutral VR scene + TBS.DiscussionThis will be the first study to examine whether the TMS modulation after VR retrieval can reduce self-reported craving and drug-related cue reactivity. It will promote the understanding of the neural circuit mechanism of the reconsolidation-based intervention and provide an effective treatment for MA use disorder patients.Clinical Trial Registration[Chinese Clinical Trial Registry], identifier [ChiCTR1900026902]. Registered on 26 October 2019.
Association Between Gestational Diabetes Mellitus and the Risks of Type-Specific Cardiovascular Diseases
Authors: Mao Yuanyuan , Hu Wenbin , Xia Bin , Liu Li , Han Xia , Liu Qin 
Published: July 2022

ObjectiveGestational diabetes mellitus (GDM) has been linked to subsequent overall cardiovascular diseases. However, evidence on the associations of GDM with type-specific cardiovascular diseases is lacking, and findings on the potential impact of type 2 diabetes on the associations are not consistent. This study aimed to explore the associations between GDM and the risks of type-specific cardiovascular diseases.MethodsData were from 12,025 women (≥20 years) who had delivered at least one live birth in the National Health and Nutrition Examination Survey, 2007–2018. GDM history and type-specific cardiovascular diseases including coronary heart disease (CHD), heart failure and stroke were defined by self-report. We also combined our results with those from previously related publications on the associations between GDM and risks of type-specific cardiovascular diseases with a random-effect model.ResultsCompared with women without GDM, the multivariable-adjusted odds ratios (95% confidence intervals) were 1.82 (1.21–2.72) for CHD, 1.43 (0.80–2.53) for heart failure, and 1.19 (0.76–1.86) for stroke among women with a history of GDM. Type 2 diabetes was associated with 43.90, 67.44, and 63.16% of the excess odds of CHD, heart failure and stroke associated with GDM, respectively. Combining results from this study with those from previously related studies yielded odds ratios (95% confidence intervals) of 1.81 (1.60–2.05) for CHD (12 studies, 7,615,322 participants, I2= 72.6%), 1.66 (1.25–2.21) for heart failure (5 studies, 4,491,665 participants, I2= 88.6%), and 1.25 (1.07–1.46) for cerebrovascular disease (9 studies, 6,090,848 participants, I2= 77.8%).ConclusionsGDM showed stronger associations with coronary heart diseases and heart failure than cerebrovascular disease, and the excess risks are attributable, in part, to type 2 diabetes.
Robot-Assisted Kyphoplasty Improves Clinical and Radiological Features Better Than Fluoroscopy-Assisted Kyphoplasty in the Treatment of Vertebral Compression Fractures: A Meta-Analysis
Authors: Yu Hongwei , Luo Gan , Yu Bin , Sun Tianwei , Tang Qiong , Jia Yutao 
Published: July 2022

PurposeThis meta-analysis aimed to determine whether patients treated with robot-assisted kyphoplasty for vertebral compression fractures have superior clinical and radiographic improvement than those treated with fluoroscopy.MethodsA comprehensive search of the PubMed, Embase, Cochrane Library, Science Direct, and CNKI (China National Knowledge Infrastructure) databases was conducted to find randomized control trials (RCTs) or observational cohort studies that compared robotic-assisted kyphoplasty (RA-kyphoplasty) with fluoroscopy-assisted kyphoplasty (FA-kyphoplasty) in treating vertebral compression fractures. Preoperative, postoperative, and final follow-up data on vertebral height (VH), vertebral kyphosis angle (VKA), visual analog scale (VAS) for back pain, and cement leakage rate were collected from eligible studies for meta-analysis. Patients were divided into RA and FA groups depending on whether the operation was robotically or fluoroscopically guided.ResultsWe included 6 cohort studies with 491 patients and 633 vertebrae. The results of the meta-analysis showed that the RA group had a higher VH than the FA group at both postoperation (p &lt; 0.001) and final follow-up (p &lt; 0.001); the VKA in the RA group was lower than that in the FA group at postoperation (p &lt; 0.001) and final follow-up (p &lt; 0.001); the back pain VAS score was lower in the RA group than in the FA group at postoperation (p = 0.01) and final follow-up (p = 0.03); and the cement leakage rate in the RA group was lower than those in the FA group (p &lt; 0.001).ConclusionThis meta-analysis demonstrated that RA-kyphoplasty outperformed FA-kyphoplasty in vertebral height restoration, kyphosis angle correction, VAS score reduction for back pain, and lower cement leakage rate in the treatment of vertebral compression fractures.
Thrips Microbiome Study in Commercial Avocado (Persea americana Mill.) from Northwest Colombian Andes (Antioquia, Colombia) Shows the Presence of Wolbachia, Ehrlichia, Enterobacter
Authors: Cano-Calle Daniela , Montoya-Porras Luisa Maria , Ochoa-Giraldo Sebastian , Junca Howard , Garcia-Bonilla Erika , Saldamando-Benjumea Clara , Moreno-Herrera Claudia Ximena , Arango-Isaza Rafael E. 
Published: July 2022

Microbiota associated with insects play several important roles in their host, including protection against pathogens, provision of nutrition, and survival in hostile environments. The aim of this work was to identify the bacterial community found in avocado thrips from Northwestern Colombia (Antioquia department) in order to find isolates for potential biocontrol purposes. Culture-dependent methods based on 16S rRNA and gyrase B gene sequencing in 42 bacterial isolates allowed the identification of the genera Bacillus, Serratia, Moraxella, Pantoea, and Sphingomonas. Microbial diversity detected with the temperature gradient gel electrophoresis (TGGE) technique on three morphotypes of thrips, named brown (Scirtothrips hansoni), black (Frankliniella panamensis), and pale (Frankliniella sp.), showed a low bacterial community density (Shannon–Wiener index = 1480, p > 0.05) with significant differences among morphotypes (R = 0.7877, p = 0.0004). Results obtained with Illumina sequencing on the V1–V2 hypervariable region of the subunit 16S rRNA showed a predominant sequence in the brown morphotype (Scirtothrips hansoni) that belongs to the genus Wolbachia. The 16S amplicon analyses were extended to more samples and higher resolution using the V4–V5 hypervariable region. The results showed six additional bacteria phyla, confirming the previous observation for the dominant bacterial groups made in S. hansoni and the detection of the alternation of highly predominant genera among these thrips. Our results demonstrate that endosymbiont such as Wolbachia sp. are part of the microbiota of these pests, thereby indicating the possibility of employing this type of bacterium to improve the management of avocado thrips globally.
Beam Wander Restrained by Nonlinearity of Femtosecond Laser Filament in Air
Authors: Guo Jiewei , Sun Lu , Liu Jinpei , Shang Binpeng , Tao Shishi , Zhang Nan , Lin Lie , Zhang Zhi 
Published: July 2022

The filamentation process under atmospheric turbulence is critical to its remote-sensing application. The effects of turbulence intensity and location on the spatial distribution of femtosecond laser filaments in the air were studied. The experimental results show that the nonlinear effect of the filament can restrain the beam wander. When the turbulence intensity was 3.31×10−13 cm−2/3, the mean deviation of the wander of the filament center was only 27% of that of the linear transmitted beam. The change in turbulence location would lead to a change in the standard deviation of the beam centroid drift. Results also show that the filament length would be shortened, and that the filament would end up earlier in a turbulent environment. Since the filamentation-based LIDAR has been highly expected as an evolution multitrace pollutant remote-sensing technique, the study promotes our understanding of how turbulence influences filamentation and advances atmospheric remote sensing by applying a filament.
Susceptibility of LoRa Communications to Intentional Electromagnetic Interference with Different Sweep Periods
Authors: De São José Artur N. , Deniau Virginie , Gransart Christophe , Vantroys Thomas , Boé Alexandre , Simon Eric Pierre 
Published: July 2022

This work presents a detailed analysis of the susceptibility of LoRa communications in the presence of intentional jamming signals. The analysis is performed with a periodic frequency-sweeping intentional electromagnetic interference, corresponding to the most common jamming signals. Such a waveform faithfully represents the signals emitted by commercial jammers. As the sweep period of the jamming signals may vary from one such device to another, the analyses are conducted with different sweep period values, from 1 μs to 50 μs. The experimental results indicate that the impact varies significantly according to the sweep period of the jamming signal. The detailed analysis allows us to identify the jamming signals to which LoRa communications can be resilient or not as well as to identify which LoRa channels are less affected during an attack.
PRODUCTIVE QUALITIES OF A NEW TYPE OF KALMYK CATTLE BEING CREATED IN THE CONDITIONS OF THE HIGH-ALTITUDE ZONE OF KABARDINO-BALKARIA
Authors: КАЮМОВ Ф.Г. , ТРЕТЬЯКОВА Р.Ф. 
Published: July 2022

Проведена сравнительная оценка роста и развития бычков базового варианта и создаваемого типа калмыцкой породы скота (F1). Подопытные животные обладали разными особенностями роста и развития в одних и тех же условиях кормления и содержания. Средняя живая масса новорожденных помесных бычков (F1) составляла 24,1 кг, а аналогов базового варианта — 22,3 кг, что на 8,1% ниже, чем у животных создаваемого типа. Во все периоды роста средняя живая масса создаваемого типа превосходила аналогов базового варианта. В возрасте 15 мес разница составила 25,6 кг (6,9%). От животных создаваемого типа за период исследований были получены более высокие среднесуточные приросты по сравнению со сверстниками базового варианта (больше на 172 г, или 25,4%), что указывает на более высокую энергию их роста. Скот создаваемого типа имел более выраженные мясные формы. Бычки базового варианта превосходили сверстников по высоте в холке и крестце, тогда как молодняк создаваемого мясного типа имел более удлиненное туловище и хорошо развитый полуобхват зада.
Federal Research Center of Biological Systems and Agrotechnologies of the Russian Academy of SciencesA comparative evaluation of the growth and development of steers of the base variant and the created type of Kalmykian cattle breed (F1) was carried out. The experimental animals had different growth and development characteristics under the same feeding and housing conditions. The average live weight of newborn F1 steers was 24.1 kg, while that of the parent type was 22.3 kg, which was 8.1% lower than that of the developed type. During all periods of growth, the average live weight of the created type exceeded that of the base type. At 15 months of age the difference was 25.6 kg (6.9%). For the period of the study, the animals of the created type had higher average daily gains compared to their counterparts of the base type (172 g, or 25.4% more), indicating higher energy of growth. The cattle of the created type had more pronounced meat forms. Bulls of the base type were superior to their peers in withers and rump height, while young beef type cattle had a more elongated torso and well-developed butt girth.
A modernização na cidade de Catalão (GO): um estudo de caso sobre a Avenida 20 de Agosto / Modernization in the city of Catalão (GO): a case study about the Avenida 20 de Agosto
Authors: Beserra Moises Alves , Silva Ronaldo , Beserra Raphaella Karla Portes , Camargo Pedro Luiz Teixeira de 
Published: July 2022

A avenida 20 de Agosto formada por residências de classe média alta no século XIX notada por ser charmosa e nobre, com Ruas de calçamento de Paralelepípedos e desejada pela burguesia sendo desde então a principal atenção desta cidade com identidade residencial, formada por grandes e luxuosas residências, ocupadas por pessoas de alto poder comercial, empresarial e político. Por conseguinte, por estar numa região central da pequena Catalão do momento, inicia-se uma transformação de uso para misto, visto que no presente momento a Avenida 20 de Agosto passa ter um uso comercial. Nesta conjectura atual devido a chegada da ferrovia inicia ao que podemos chamar transformação. Surge um conjunto de impactos e as pessoas começam a migrar para novos bairros, e as charmosas casas começam a se tornar comércios, escritórios e serviços. E suposto que muitas casas foram demolidas por causa das suas frágeis estruturas. E isso é só o começo da transformação que influencia um crescimento e surgimento de novas ruas comerciais no entorno, novos bairros, atrativo para novas empresas e novos investidores. A avenida 20 de agosto é um instrumento urbano que se transformou, mas, as marcas do tempo, da arquitetura e do espaço geográfico continuam vivos, através da história, das edificações que foram adaptadas mas não perderam os traços arquitetônico da forma construtiva, de residências que ainda perduram, a forma da rua continua, a praça Getúlio Vargas apesar da reforma extravagante ainda continua com os mesmos traços. Os conjuntos de adaptações trouxeram os impactos sociais, políticos, ambientais e urbanísticos. Os impactos trouxeram novas empresas, novos investimentos e novos estilos arquitetônicos. Toda essa problemática surgiram como sendo o resgate à qualidade das mudanças, à procura de um melhor planejamento urbano e mecanismos de controle ambiental, para que tanto o crescimento econômico quanto as demandas sociais sejam beneficiados.
Influência do pH na microestrutura e nas propriedades fisicas do suco de umbu em pò obtido por cocristalização / Effect of pH on microstructure and physical properties of umbu juice powder obtained by cocrystallization
Authors: Cano-Chauca Milton Nobel , Vieira Claudia Regina , Lima William James Nogueira , Dos Santos Marcos Ferreira , Santos Gabriela Fernanda da Cruz , Fonseca Kelem Silva , Silva Lívia Aparecida Gomes , Amaral Heron Ferreira 
Published: July 2022

O trabalho teve como objetivos determinar a influência do pH na microestrutura e nas propriedades funcionais de densidade aparente, fluidez e de solubilidade em co-cristalizados de suco de umbu. Para a realização deste trabalho foi utilizada polpa de umbu, adquirida no comércio local com teor médio de sólidos totais de 16%. Antes do processo a polpa sofreu correção de pH para pH 3,5; pH 4,0 e pH 4,5 utilizando-se CaCO3. Para a preparação do produto foi utilizada polpa na concentração de 10, 15 e 20% (p/p). O processo de cocristalização consiste na concentração de um xarope de sacarose até a supersaturação, quando então é adicionada a polpa, em seguida, a mistura é submetida a uma intensa agitação que induz a formação de nucleação e aglomerados do produto. As amostras foram secas em estufa e armazenadas. A análise de microscopia eletrônica ilustra que o suco em pó apresentou superfícies cristalinas em todos os tratamentos. As análises de solubilidade e ângulo de repouso indicaram que não houve interação entre pH concentração do suco, ou seja, agiram independentemente apresentando valores de solubilidade satisfatórios em torno de 37s e 42º, respectivamente. A análise de densidade aparente mostrou que houve interação entre pH e concentração do suco resultando em valores próximos a 0,85 g/cm3,valores similares à sacarose. Pode-se concluir que o suco em pó obtido por cocristalização resultou em um produto com boa fluidez, solubilidade e densidade aparente o que o torna um processo ideal de conservação.