bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune complex stimulation of human neutrophils involves a novel Ca2+/H+ exchanger that participates in the regulation of cytoplasmic pH: flow cytometric analysis of Ca2+/pH responses by subpopulations
Authors: Bernardo John , Hartlaub Hilary , Yu Xin , Long Heidi , Simons Elizabeth R 
Published: September 2022

AbstractThe activation of human phagocytic leukocytes by immune complexes (IC) or opsonized microbes via their Fc and complement receptors has been well-described (for reviews, see refs. [1–3]). The mechanisms involved in this process are complex and depend on the receptors involved. The biochemical events that lead to the destruction of invading organisms in turn display varying degrees of interdependence, but the controlling elements that lead to the ultimate killing of ingested organisms within phagosomes by lysosomal enzymes and reactive oxygen intermediates are still not completely understood. We have addressed these mechanisms by following and correlating the kinetics of responses by individual cells, using multiparameter flow cytometry [3, 4]. Using nonopsonized IC as stimuli, we document here the presence of a novel Ca2+/H+ voltage-independent channel in human neutrophils, which helps to control their cytoplasmic pH.
Institution of Standardized Consultation Criteria to Increase Early Palliative Care Utilization in Older Patients With Acute Leukemia
Authors: Rosenblum Rachel E. , Ormond Ellen , Smith Crystal W. , Bilderback Andrew L. , Altieri Dunn Stefanie C. , Buchanan Dan , Geramita Emily M. , Rossetti James M. , Bhatnagar Mamta , Arnold Robert M. 
Published: September 2022

PURPOSE: Older patients with acute leukemia (AL) have a high symptom burden and poor prognosis. Although integration of palliative care (PC) with oncologic care has been shown to improve quality-of-life and end-of-life care in patients with AL, the malignant hematologists at our tertiary care hospital make limited use of PC services and do so late in the disease course. Using the Plan-Do-Study-Act (PDSA) methodology, we aimed to increase early PC utilization by older patients with newly diagnosed AL. METHODS: We instituted the following standardized criteria to trigger inpatient PC consultation: (1) age 70 years and older and (2) new AL diagnosis within 8 weeks. PC consultations were tracked during sequential PDSA cycles in 2021 and compared with baseline rates in 2019. We also assessed the frequency of subsequent PC encounters in patients who received a triggered inpatient PC consult. RESULTS: The baseline PC consultation rate before our intervention was 55%. This increased to 77% and 80% during PDSA cycles 1 and 2, respectively. The median time from diagnosis to first PC consult decreased from 49 days to 7 days. Among patients who received a triggered PC consult, 43% had no subsequent inpatient or outpatient PC encounter after discharge. CONCLUSION: Although standardized PC consultation criteria led to earlier PC consultation in older patients with AL, it did not result in sustained PC follow-up throughout the disease trajectory. Future PDSA cycles will focus on identifying strategies to maintain the integration of PC with oncologic care over time, particularly in the ambulatory setting.
Acid–Base Imbalance in Pseudohypoaldosteronism Type 1 in Comparison With Type IV Renal Tubular Acidosis
Authors: Adachi Masanori , Nagahara Keiko , Ochi Ayako , Toyoda Junya , Muroya Koji , Mizuno Katsumi 
Published: September 2022

Abstract

Context
Pseudohypoaldosteronism type 1 (PHA1) has been treated as a genetic variant of type IV renal tubular acidosis (RTA), leading to the conception that PHA1 develops hyperchloremic acidosis with a normal anion gap (AG).

Objective
To delineate the acid–base imbalance in PHA1A (dominant type) and PHA1B (recessive type).

Methods
We conducted the following: (1) a retrospective chart review of our patient with PHA1B, and (2) a literature search of PHA1 cases focusing on acid–base balance. The main outcome measures were the incidence and nature of acidosis, including chloride levels and AG.

Results
In our patient with PHA1B, 7 salt-wasting episodes were analyzed. Acidosis was ascertained each time, and it was accompanied by hypochloremia except in 1 episode. AG was elevated in 5 episodes, while hyperlacticaemia was present in 3. In the literature, 41 cases of PHA1A and 65 cases of PHA1B have been identified. During salt-wasting crises, acidosis developed in 85% of PHA1A cases and 87% of PHA1B cases. Hypochloremia was present in 69% of PHA1A cases with available data (n = 13) and 54% of eligible PHA1B cases (n = 13), with mean chloride levels of 96 mEq/L and 95 mEq/L, respectively. Increased AG was less frequently reported (14% in PHA1A and 44% in PHA1B).

Conclusions
Patients with PHA1 frequently presented with metabolic acidosis. However, hyperchloremia may not be a universal finding, whereas hypochloremia and increased AG may occur in a substantial proportion of the patients.
Insulin Resistance and Its Association With Osteoporosis in People Living With HIV
Authors: Caeran Gabriela , de Almeida Luciana L , Ilha Thales A S H , de Carvalho José A M , Stein Carolina , Moresco Rafael N , Haygert Carlos J P , Comim Fabio V , Premaor Melissa O 
Published: September 2022

Abstract

Background
Despite the gain in life expectancy that people living with HIV (PLHIV) have had in the past few years, the disease is accompanied by an increase in the prevalence of noninfectious chronic diseases. PLHIV have a higher prevalence of osteoporosis, fracture, diabetes mellitus, and insulin resistance than the general population. It is unknown if insulin resistance is associated with osteoporosis and fractures in PLHIV. Our study aimed to assess the association between insulin resistance and osteoporosis in PLHIV.

Methods
A cross-sectional study was carried out in southern Brazil. PLHIV ages 50 years or older on antiretroviral treatment were included. Insulin resistance was considered present when the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) was higher than expected for the Brazilian population (&gt;2.7). The triglyceride-glucose (TyG) index was also calculated.

Results
Of the 101 PLHIV who agreed to participate, 84 underwent insulin and bone mineral density measurements. The prevalence of osteoporosis was 19%. The frequency of insulin resistance calculated by HOMA-IR was 68.2%. Participants with osteoporosis had lower body mass index (BMI) and triglyceride values than those without it. HOMA-IR [4.8(6.6) vs 8.68(9.6), P = 0.013] and TyG [5.0(0.3) vs 5.2 (0.4), P = 0.029]. The association between the total femur t-score disappeared after correction for BMI in the linear regression model. There was no association between vertebral fractures and insulin resistance.

Conclusion
In our study, PLHIV with osteoporosis have lower insulin resistance than PLHIV without it. However, this finding appears to be related to lower BMI. The association between insulin resistance and bone in PLHIV appears to be somewhat similar to that of the general population.
Whaddayou Mean “ςπουδαιογɛλοιον”?: Nabi's Last Laugh
Authors: Marshall T. C. 
Published: September 2022

Abstract
In his late unpublished essay “Dionysus in 1992,” Norman O. Brown arrived at the ancient Greek term “spoudaiogeloion” to express his idea of a “serious laughter” that could respond to dialectical tensions without unbalancing them. Brown had, in 1959, converted Freud's Witz book into a serious theory of art. This turned the focus on humor into a focus on art, subtly repressing the place of laughter in art and thinking for Brown and those who took him seriously. His casual conversation was always full of fun, but his formal thought lacked that liberating concept until the last decade of his life. Not even the accusation by Marcuse of “mystification” could bring him out of his idealizations—until he saw the dialectical power of humor's ambivalence. “Spoudaiogeloion,” with room for Joyce's farcical wit and Blake's high visions, gave Brown a useful “way out” of tensions between “high” and “low” art or philosophy.
Nobby, or Metamorphosis
Authors: Schelling Andrew 
Published: September 2022

Abstract
Andrew Schelling recalls and discusses a college course, “World Poetry,” which Norman O. Brown taught at University of California, Santa Cruz, in 1974. The turbulent politics and weird, harrowing culture changes of North America set a context. Brown's class met weekly in a remote meadow ringed by second-growth redwoods. Brown developed his interest in the “law of metamorphosis,” which he thought poetry captures, and put his attention on how the human body changes, producing text as sound or performance. Using two anthologies compiled by Jerome Rothenberg, Brown drew students into a poetry that was physical, raw, multilingual, and perhaps a scriptural base for the era's counterculture. Schelling portrays Brown as a quixotic figure, Sir John Falstaff among scholars. A quick sketch of the “Santa Cruz ecosystem” brings into the mix Gregory Bateson, whose thoughts on evolution paralleled Brown's on poetry, and Jan Willis, veteran civil rights activist and scholar of Sanskrit.
Introduction to the Correspondence of Robert Duncan and Norman O. Brown
Authors: Davidson Michael 
Published: September 2022

Abstract
The following selections from letters exchanged between Robert Duncan and Norman O. Brown display the range and interest of their extensive correspondence. The correspondence was generative for both figures, and shows a degree of mutual affection and personal concern beyond their intellectual interests. The letters are retrieved from the special collections libraries at the University of California, Santa Cruz, and the University of Buffalo.
To Greet the Return of the Gods: A Guide for Teachers
Authors: Brown Norman O. 
Published: September 2022

Abstract
In this introduction to the Book of Ours student manual and its accompanying lectures and workshops, Norman O. Brown discusses processes for transforming the structure, dynamics, and spirit of conventional large-enrollment undergraduate courses. Brown maps the aims and intentions of the Book of Ours project as a recreation of “mythic consciousness by mythopoeic activity,” and in this way lays out a path to a more “poetical and sacred” style of academic engagement.
“A More Personal Look at Her Life”: Family Narrative, Gender, and Transnational Memories in The Girl and the Picture
Authors: Zhang Pingfan 
Published: September 2022

Abstract
Recent decades have witnessed a booming film industry portraying the Nanjing Massacre, both within and outside Mainland China, which is closely related to contemporary Chinese political, socioeconomic, and cultural transformations. This article examines the USC Shoah Foundation's 2018 documentary film The Girl and the Picture, featuring the well-known Nanjing Massacre female survivor Xia Shuqin. It argues that the cinematic rendition of Xia's family stories serves as a piercing incision into Nanjing Massacre historical memories and weaves together the personal with the national, and transgenerational with transnational memories. The Girl and the Picture radicalizes cinematic discourses on the Nanjing Massacre from multiple angles and not only sheds light on the emerging field of Nanjing Massacre studies but also contributes to our understanding of the ongoing memory boom of the Nanjing Massacre in the context of globalization. By delivering the stories of Xia along both family and transnational lines, The Girl and the Picture points out a new way to cope with the memory crisis of the Nanjing Massacre, and to take responsibility for transmitting the memories across generational, national, gender, and ethnic boundaries.
The Language(s) of Self-Representation
Authors: Allan Michael 
Published: September 2022

Abstract
This essay tracks Karl Marx's famous line “They cannot represent themselves; they must be represented” as it travels from a translated epigraph in Edward Said's Orientalism to Gayatri Chakravorty Spivak's “Can the Subaltern Speak?” What follows from this minor textual detail is a broader exploration of how “other” languages take place in postcolonial theory—not only Said and Spivak's German, but Abdelfattah Kilito's Italian and Frantz Fanon's Arabic. What is the place of translation in self-representation? How do instances of textual citation complicate the self of self-representation? In the ricochet between citation and translation, language matters not necessarily as a sign of fluency, but as part of a pragmatics of critique, positionality, and ultimately solidarity. Each instance of language-use (German, Italian, Arabic) highlights the potentials of re-use, citation, and re-imagination for consolidating the bonds of anticolonial struggle and a vision of a postcolonial future. Shifting from translation to resonance and from language to voice, the essay ultimately engages the poetic potentials of translation as part of a pragmatics of anticolonial solidarity, integral to and beyond the self at the heart of self-representation.
Premature Ejaculatory Dysfunction in Rheumatoid Arthritis (PED-RA Study)
Authors: Wagan Abrar Ahmed , Chandio Sultan Ahmed , Surahyo Paras 
Published: September 2022

Objective: To determine the frequency of premature ejaculatory dysfunction in rheumatoid arthritis patients.
Methods: After approval from IRB, cross sectional study was conducted from November 1st, 2020 to August 1st, 2021 at Department of Rheumatology, Indus Medical College, Pakistan. RA patients were included, written and informed consents were taken. Demographic data was noted and detailed history and examination was carried out. Each participant BMI and Blood pressure was measured. Afterward 5-ml of blood was drawn by a trained phlebotomist for CBC, ESR, fasting blood sugar levels, HBs Ag and anti HCV Antibody test. DAS-28 Calculator was used for RA clinical activity. Premature ejaculation diagnostic tool was used for the assessment of premature ejaculation.
Results: Total 168 patients with mean age 32.27 (SD=±9.49) and mean disease duration of 6.35 (SD=±3.95) years were included,. Prevalence of premature ejaculation dysfunction was (44.6%), with mean PED of score 9.17 (SD=±5.23). Hypertension, HCV, Hakeem medications, use of DMARDS had positive association while High BMI and higher DAS-28 has negative association with PED (p<0.05).
Conclusion: There is high prevalence of PED in RA, it needs proper evaluation, treatment and urgent research is needed to know more about it.
doi: https://doi.org/10.12669/pjms.38.8.5698
How to cite this:Wagan AA, Chandio SA, Surahyo P. Premature Ejaculatory Dysfunction in Rheumatoid Arthritis (PED-RA Study). Pak J Med Sci. 2022;38(8):---------. doi: https://doi.org/10.12669/pjms.38.8.5698
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Modeling anticipated changes in numbers of SARS-CoV-2 infections within communities due to immunization campaigns
Authors: Frey Kurt , Hagedorn Brittany , McCarthy Kevin A. , Hutubessy Raymond , Wang Susan Annemarie 
Published: September 2022

Background: As SARS-CoV-2 spread in early 2020, uncertainty about the scope, duration, and impact of the unfolding outbreaks caused numerous countries to interrupt many routine activities, including health services. Because immunization is an essential health service, modeling changes in SARS-CoV-2 infections among communities and health workers due to different vaccination activities was undertaken to understand the risks and to inform approaches to resume services. Methods: Agent-based modeling examined the impact of Supplemental Immunization Activities (SIAs) delivery strategies on SARS-CoV-2 transmission in communities and health workers for six countries capturing various demographic profiles and health system performance: Angola, Ecuador, Lao PDR, Nepal, Pakistan, and Ukraine. Results: Urban, fixed-post SIAs during periods of high SARS-CoV-2 prevalence increased infections within the community by around 28 [range:0-79] per 1000 vaccinations. House-to-house SIAs in mixed urban and rural contexts may import infections into previously naïve communities. Infections are elevated by around 60 [range:0-230] per 1000 vaccinations, but outcomes are sensitive to prevalence in health workers and SIA timing relative to peak. Conclusions: Incremental increases in SARS-CoV-2 infection due to SIAs was small and in proportion to overall prevalence. Younger populations experience lower transmission intensity and fewer excess infections per childhood vaccine delivered. Large rural populations have lower transmission intensity but face a greater risk of introduction of SARS-CoV-2 during an SIA.
Internet Gaming Addiction among High School Students in Kendawangan against Sleep Quality and Learning’s Motivation
Authors: Permana Iman , Retnosari Retnosari 
Published: September 2022

With the advance of information technology internet gaming has been showing to increase globally and across Indonesia. This phenomenon has been correlated to the decreasing the quality of sleep as well as learning motivation, and academic performance. This study aimed to analyze the relationship between gaming addiction and sleep quality and learning motivation among high school students in Kendawangan. A cross-sectional study was conducted among 33 high school students using questionnaires to assess the quality of sleep, motivation and gaming addiction. Results showed almost a quarter of sample were highly addicted. There was a significant relationship between gaming addiction and sleep quality (p 0.002, p<0.05) as well as with learning motivation (p 0.002, p<0.05). Thus, gaming addiction influenced quality of sleep and learning motivation among the high school students.
Prevalence and Risk Factors of Soil-transmitted Helminth Infections in Cattle Breeders in Mlaten Village, East Java
Authors: Ridwan Muhammad Aviv Nur , Charisma Acivrida Mega 
Published: September 2022

Background: Soil-transmitted helminth infections are diseases caused by the ingestion of infective stages (in the form of eggs, larvae, cysticercoid, and plerocercoid) of worms (nematodes, cestodes, and trematodes) into the human gastrointestinal tract through the fecal-oral route. The risk factors associated with soil-transmitted helminth infections are environmental factors and hygiene factors. These factors are commonly found in agricultural areas. Therefore, we conducted research in Mlaten Village because the majority of the villagers work as cattle breeders. In addition, the surrounding community, especially cattle breeders, experienced excessive diarrhea that was probably caused by a lack of hygiene knowledge, poor sanitation, and low awareness of cattle care and management. This study aims to determine the prevalence and risk factors of soil-transmitted helminth infections in cattle farmers in Mlaten village, Mojokerto, East Java. Methods: This research was conducted using a survey method and cross-sectional study design with 30 cattle farmers as respondents. Human and cow feces were identified using a staining method in the form of 2% eosin. We also used questionnaires to determine the risk factors. The data obtained were presented descriptively and risk factors were analyzed using the chi-square test. Results: The results showed that the habit of cutting nails (OR= 0.083; CI 95%= 0.007-0.950; p<0.05), the habit of washing hands (OR= 0.000; CI 95%= 0.000-0.000; p<0.05), and the habit of washing hands with soap (OR= 0.040; CI 95%= 0.267-18.925; p<0.05) have a significant effect on the incidence of soil-transmitted helminth infections. Conclusion: The prevalence of soil-transmitted helminth infections is significant to personal hygiene risk factors.
Rede de Sensores para avaliação de variáveis meteorológicas em áreas verdes urbanas: desenvolvimento e aplicações
Authors: Chaves Jô Vinícius Barrozo , Mota Lia Toledo Moreira , Longo Regina Márcia , Ribeiro Admilson ´Írio , Barros Daniel Braga , Alves José Ricardo 
Published: September 2022

A construção de ambientes urbanos pouco sustentáveis, muitas vezes, implica em impactos negativos no clima e no conforto ambiental, devido às interferências climáticas comuns em ambientes altamente construídos e impermeabilizados. Nesse sentido, uma das formas de mitigação dos impactos ambientais e microclimáticos negativos consiste na criação e ampliação de áreas verdes no ambiente urbano. Assim, a análise da influência das áreas verdes no meio ambiente urbano é de fundamental importância para a avaliação de seu impacto no microclima urbano. Essa análise pode ser realizada por meio do monitoramento de variáveis meteorológicas. Nesse sentido, o emprego de instrumentos e metodologias de aquisição de informação podem contribuir positivamente para essa análise, como forma de subsídio para a tomada de decisões relacionada ao planejamento urbano. Nesse contexto, esse trabalho teve como objetivo o desenvolvimento de uma rede de sensores, cujos elementos principais são nós-sensores para avaliação de variáveis meteorológicas em áreas verdes urbanas, visando analisar e discutir a influência de áreas verdes no comportamento dos parâmetros de concentração de CO2, temperatura e umidade relativa do ar. Os nós-sensores propostos e desenvolvidos possibilitaram a coleta adequada dessas variáveis. A partir dos resultados obtidos, foi possível observar que a área verde (área de preservação permanente - APP) contribuiu positivamente com essas variáveis na parcela da área de estudo localizada em Campinas (SP), apresentando menor temperatura e concentração de CO2 e aumento da umidade do ar. Porém, para a parcela de Paulínia (SP), pôde-se observar pouca influência da APP. Foram identificadas, ainda, influências nessas variáveis exercidas por áreas rurais e parques, contribuindo para a redução dos parâmetros meteorológicos, mas com diferentes interações com a concentração de CO2, podendo apresentar possível aumento ou auxiliar na redução de CO2 no ar.
All Opinions Matter
Authors: Rieber Lloyd , Zimeri Anne Marie , Li Tong 
Published: September 2022

This paper describes a study, in the form of multiple field tests, designed to help students in an environmental health science course express and understand the subjective perspectives that they and their classmates hold on important course topics. This study is part of a project using the Q sorting technique found in Q methodology as the basis for a classroom activity, an approach we term Q pedagogy. Q methodology is a research methodology designed to study people’s subjectivity and was first formulated by William Stephenson in the 1930s. Results show that the Q pedagogy activity was effective in promoting individual reflection and group discussion among students in the class. Q pedagogy adapts the rich, mixed methods research approach of Q methodology for instruction to advance the Scholarship of Teaching and Learning (SoTL).