bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary thyroid gland myxofibrosarcoma: a case report and review of the literature
Authors: Stylianidi Maria Chara , Haeberle Lena , Schott Matthias , Mori Yuriko , Antke Christina , Giesel Frederick Lars , Antoch Gerald , Esposito Irene , Knoefel Wolfram Trudo , Krieg Andreas 
Published: July 2022

Abstract
Background
Myxofibrosarcoma is a common soft tissue sarcoma of the extremities, which occurs very rarely in the thyroid gland.

Case presentation
We report the case of a 61-year-old male who presented with a swelling of the left side of the neck and a newly emerged hoarseness. Ultrasound depicted a hypoechoic thyroid nodule with microcalcifications that was highly suspicious for malignancy. He underwent a left hemithyroidectomy. Histopathological examination and immunohistochemical studies revealed a myxofibrosarcoma of the thyroid gland.

Conclusion
Myxofibrosarcoma of the thyroid gland is extremely rare. The diagnosis is based on histopathological features. Radical surgery achieving tumor-free resection margins remains the only chance for cure. However, the role of radiotherapy and/or chemotherapy is still under debate. Due to their high tendency for locoregional recurrence, a close follow-up after surgery is mandatory.
Prevalence and risk factors of malaria among first antenatal care attendees in rural Burkina Faso
Authors: Lingani Moussa , Zango Serge H. , Valéa Innocent , Sanou Maïmouna , Ouoba Serge , Samadoulougou Sékou , Robert Annie , Tinto Halidou , Dramaix Michèle , Donnen Philippe 
Published: July 2022

Abstract
Background
The WHO recommends continuous surveillance of malaria in endemic countries to identify areas and populations most in need for targeted interventions. The aim of this study was to assess the prevalence of malaria and its associated factors among first antenatal care (ANC) attendees in rural Burkina Faso.

Methods
A cross-sectional survey was conducted between August 2019 and September 2020 at the Yako health district and included 1067 first ANC attendees. Sociodemographic, gyneco-obstetric, and medical characteristics were collected. Malaria was diagnosed by standard microscopy and hemoglobin level was measured by spectrophotometry. A multivariate logistic regression analysis was used to identify factors associated with malaria infection.

Results
Overall malaria infection prevalence was 16.1% (167/1039). Among malaria-positive women, the geometric mean parasite density was 1204 [95% confidence interval (CI) 934–1552] parasites/µL and the proportion of very low (1–199 parasites/µL), low (200–999 parasites/µL), medium (1000–9999 parasites/µL) and high (≥ 10,000 parasites/µL) parasite densities were 15.0%, 35.3%, 38.3% and 11.4%, respectively. Age < 20 years (adjusted odds ratio (aOR): 2.2; 95% CI 1.4–3.5), anemia (hemoglobin < 11 g/deciliter) (aOR: 3.4; 95% CI 2.2–5.5), the non-use of bed net (aOR: 1.8; 95% CI 1.1–2.8), and the absence of intermittent preventive treatment with sulfadoxine–pyrimethamine (aOR: 5.8; 95% CI 2.1–24.5) were positively associated with malaria infection.

Conclusions
The study showed that one out of six pregnant women had a microscopy-detected P. falciparum malaria infection at their first ANC visit. Strengthening malaria prevention strategies during the first ANC visit is needed to prevent unfavorable birth outcomes.
Task-unrelated thought increases after consumption of COVID-19 and general news
Authors: Hart Chelsie M. , Mills Caitlin , Thiemann Raela F. , Andrews-Hanna Jessica R. , Tomfohr-Madsen Lianne , Kam Julia W. Y. 
Published: July 2022

AbstractTask-unrelated thoughts (TUTs) are frequent distractions from our everyday tasks, which can reduce productivity and safety during task performance. This necessitates the examination of factors that modulate TUT occurrence in daily life. One factor that has previously been implicated as a source of TUT is personally salient concerns. External factors such as news media serve as cues for these concerns, potentially increasing TUT occurrence. However, this has not been thoroughly examined in everyday life settings. We thus utilized Ecological Momentary Assessment to survey participants throughout the day for ten days, on their TUTs and news consumption in two separate studies. Study 1 focused on the impact of news related to the Coronavirus Disease (COVID-19) pandemic, as a common and global concern. We found that TUT occurrence was significantly predicted by COVID-19 news consumption, such that TUT occurrence increased with COVID-19 news consumption. To extend these findings, we implemented Study 2 using similar methods, but focusing on the consumption of news media in general. TUT occurrence was predicted by general news consumption, with an increase in reports of TUT following consumption of news media in general. We thus extended the association found between TUT and COVID-19-related news in Study 1, to any news topic in Study 2. We speculate that the increase in TUTs was due to heightened salience of current concerns, cued by the news. These findings highlight the importance of considering when we choose to consume news media and the value of examining contextual factors when studying TUTs in daily life.
SAPHO—a diagnosis to consider in patients with refractory costochondritis
Authors: Parra-Izquierdo Viviana , Cubides Hector , Rivillas Viviana , Frías-Ordoñez Juan Sebastián , Mora Sergio , Ermann Joerg 
Published: July 2022

Abstract
Background
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare, heterogeneous, self-limited disease of unknown etiology. It involves progressive bone and joint damage, and skin and bone lesions may occur at different times in the course of the disease. Skin lesions are characterized by neutrophil dermatosis. Its management is empirical and mainly symptomatic, and nonsteroidal anti-inflammatory drugs are the first-line treatment.

Case presentation
Forty-seven-year-old female presented with a 7-year history of costochondral pain. It had progressive onset, chronical course, with no other associated symptoms, and no other joint involvement. She was treated with intermittent NSAID (nonsteroidal anti-inflammatory drugs), which provided only partial pain relief; there was bilateral tender swelling of the sternoclavicular region, the skin over the sternoclavicular area was slightly erythematous, but there were no other skin lesions, and based on imaging findings, a diagnosis of SAPHO syndrome was established. The patient received an infusion of zoledronic acid with subsequent complete resolution of her chest wall symptoms, and completely improved after 3 days.

Conclusions
This case is considered atypical presentation of SAPHO syndrome, without skin changes, long-term persistence of refractory symptoms, and the diagnosis was established by imaging, with complete resolution after zoledronic acid infusion. SAPHO is a differential diagnosis in patients with chronic costochondritis. Therapeutic failure to NSAID is a key to its diagnostic suspicion. Also, early diagnostic suspicion is associated with better outcomes.
Tissue-specific transcriptome profiles identify functional differences key to understanding whole plant response to life in variable salinity
Authors: Booth Mitchell W. , Breed Martin F. , Kendrick Gary A. , Bayer Philipp E. , Severn-Ellis Anita A. , Sinclair Elizabeth A. 
Published: July 2022

ABSTRACT
Plants endure environmental stressors via adaptation and phenotypic plasticity. Studying these mechanisms in seagrasses is extremely relevant as they are important primary producers and functionally significant carbon sinks. These mechanisms are not well understood at the tissue level in seagrasses. Using RNA-seq, we generated transcriptome sequences from tissue of leaf, basal leaf meristem and root organs of Posidonia australis, establishing baseline in situ transcriptomic profiles for tissues across a salinity gradient. Samples were collected from four P. australis meadows growing in Shark Bay, Western Australia. Analysis of gene expression showed significant differences between tissue types, with more variation among leaves than meristem or roots. Gene ontology enrichment analysis showed the differences were largely due to the role of photosynthesis, plant growth and nutrient absorption in leaf, meristem and root organs, respectively. Differential gene expression of leaf and meristem showed upregulation of salinity regulation processes in higher salinity meadows. Our study highlights the importance of considering leaf meristem tissue when evaluating whole-plant responses to environmental change.
This article has an associated First Person interview with the first author of the paper.
Comparative transcriptomics of tropical woody plants supports fast and furious strategy along the leaf economics spectrum in lianas
Authors: Sezen U. Uzay , Worthy Samantha J. , Umaña Maria N. , Davies Stuart J. , McMahon Sean M. , Swenson Nathan G. 
Published: July 2022

ABSTRACTLianas, climbing woody plants, influence the structure and function of tropical forests. Climbing traits have evolved multiple times, including ancestral groups such as gymnosperms and pteridophytes, but the genetic basis of the liana strategy is largely unknown. Here, we use a comparative transcriptomic approach for 47 tropical plant species, including ten lianas of diverse taxonomic origins, to identify genes that are consistently expressed or downregulated only in lianas. Our comparative analysis of full-length transcripts enabled the identification of a core interactomic network common to lianas. Sets of transcripts identified from our analysis reveal features related to functional traits pertinent to leaf economics spectrum in lianas, include upregulation of genes controlling epidermal cuticular properties, cell wall remodeling, carbon concentrating mechanism, cell cycle progression, DNA repair and a large suit of downregulated transcription factors and enzymes involved in ABA-mediated stress response as well as lignin and suberin synthesis. All together, these genes are known to be significant in shaping plant morphologies through responses such as gravitropism, phyllotaxy and shade avoidance.
Autism spectrum disorder in architecture perspective: a review of the literature and bibliometric assessment of research indexed in Web of Science
Authors: Moniem Ali Reham , El-Wakeel Hala A. , Al-Saleh Deema Faisal , Shukri Mai Ibrahim , Ansari Khadeeja M N 
Published: July 2022

Purpose: An increasing number of scholarly publications on autism spectrum disorder (ASD) have urged researcher interest in this topic; however, there is still a lack of quantitative analysis. Therefore, this study aims to cover the knowledge gap between the amount of literature published on ASD research on architectural and designers' perspectives compared to the medical and psychological fields. The study has analyzed global research output on ASD from a designer's perspective to recognize this gap related to designing the physical environment. Methodology: The bibliometric method was employed to analyze the published literature from 1992–to 2021. 812 papers were downloaded from the Web of Science for analysis based on annual growth of literature, prolific authors, authorship pattern, organizations, countries, international collaboration, and subject development by keywords and thematic map analyses. Various bibliometric and scientometric software was used to analyze the data, namely Bibexcel, Biblioshiny, and VOS viewer. Results: The812 research papers were published in 405 sources. 2019 appeared as a productive year (NP=101), and 2014 received the highest number of citations (TC=6634). Researchers preferred to publish as journal articles (NP=538; TC=24922). The University of Toronto, Canada, was identified as a productive institution with 42 publications and 5358 citations. The USA was the leading producing country with 433 publications, and most of the researchers published in the journal "Scientific Reports" (NP=16). The word autism (NP=257) and architecture (NP=165) were more frequently used keywords. Conclusion: The study identified a massive gap in the development of literature in ASD for architecture design and built environment perspective, the most important and trending keywords are missing, and the analyses also showed a lack of subject development. The authors have suggested areas and keywords for further research to fulfill the gap in the future.
Health professionalism and health profession education in the 21st century: an example of pharmacy education
Authors: Ploylearmsang Chanuttha 
Published: July 2022

The dramatic, rapid and uncertain changes from the 20th to the 21st century are called global megatrends. Such trends are the emerging and re-emerging infectious diseases, an aging society, environmental hazards, behavioural risks, and more complicated lifestyles of humans in the digital age with advanced information technology (IT) that impact much on epidemiological transitions, health security and healthcare. Health professionals are the key persons for dealing with these challenging healthcare trends. The next generation of health professionals should be equipped with high professionalism especially for the components of humanism that artificial intelligence (AI) cannot replicate. Moreover, interprofessional collaborative teamwork among health professionals is a required skill for working in dynamic transitions such as the coronavirus disease 2019 (COVID-19) pandemic. Interprofessional education (IPE) is one of the essential strategies for enhancing teamwork skills in learners. Six previously reported trends in health profession education for the 21st century are summarized, including interprofessional education, longitudinal integrated clinical education, understanding partnerships and social determination of health in patients, life-long learning, competency-based skills changeable over time, and AI and IT integrated in education. The connection among megatrends, trends in healthcare, health professionalism and health professional’s education will be important issues in academia for both health educators and health professionals.
Co-creation methodology with Smart technologies in Health and well-being to enable communication between isolated and disperse small communities: a literature review
Authors: RAMOS Victoria ,   MELTIC partners, de San Pedro Iris , Casado Elvira , Santacruz Esmeralda , Hernández Coral , Alcoceda Jose A. , de Tena-Davila M.Jose , Burgos Alfredo , Perez de la Camara Santiago , Marina-Boillos Pablo , Pascual Mario 
Published: July 2022

Objective: The objective is to determine reported cases of co-creation methodology about the use of smart technologies in public spaces in order to create new forms of social interactions and practices, which in turn creates new socio-spatial relations and promotes interactions and communication between isolated and disperse communities. Methods: The literature published in the last 5 years (2016-2020) has been reviewed. Searches on Co-creation methodology and ICTs in Health and Biomedicine, on topics such as interaction among users, ICT and social behaviour, spatial analyses, planning methodologies and public involvement, on-line gaming, self‐learning, and the prevention of risky habbits were made manually. Results: Search strategies developed through electronic databases and manual search identified a total of 180 references, included in the supplementary material. They have been divided by the technologies used in the studies, co-creation methodology, and according to the type of socio-medical application. This research highlights the penetration of ICT in social and healthcare environments and clearly demonstrates the high number of publications that have come out over recent years and a lack of publications that evaluate co-creation methodology in this field. Conclusions: Most of the papers included only partially cover the subject matter of ICT in Health and Biomedicine and how to use smart technologies to transform public spaces in small communities into people-friendly human environments. The research carried out for this paper clearly demonstrates the high number of publications concerning technology assessment. However, there is a distinct lack of publications that evaluate co-creation methodology.
Cognitive impairment restoration in patients suffered with stroke during the post-COVID period
Authors: Stoyanov O. , Son A. , Vastyanov R. , Turchin N. , Gruzevsky O. , Yermuraki P. , Dzygal O. , Vastyanov M. 
Published: July 2022

Frequency of vascular complications, including strokes, in patients suffered from COVID-19 infection is known to be increased up to 8 times, especially compared with influenza. The purpose: to investigate the fundamental mechanisms of brain ischemia in the patients with mnestic dysfunctions who previously underwent COVID-19 through pharmacocorrection via Phenibut (g-amino-b-phenylbutyric acid hydrochloride) and magnetic therapy in the early recovery period of ischemic stroke. The authors describe the possibilities of cognitive rehabilitation for people who have had ischemic stroke in the post-COVID period. Considering that the presence of mnestic dysfunctions has a negative impact on the process of rehabilitation of cerebral accidents, the fundamental mechanisms of brain ischemia in patients with mnestic dysfunctions in the early recovery period in patients who have undergone COVID-19 have been studied through pharmacocorrection via Phenibut (g-amino-b-phenylbutyric acid hydrochloride) and magnetic therapy. 46 patients aged 40 to 60 years were examined. A comparative study of three randomized clinical groups of patients with separate and complex use of Phenibut and magnetic stimulation. The effectiveness of the proposed therapy in restoring executive functions was established on the basis of indicators of the MMSE scale, the test for the study of frontal dysfunction – FAB, regression of depressive symptoms and is characterized by a decrease in the score on the GDS scale. The authors conclude that mnestic disorders are a functional "target" in cerebral ischemia in the post-COVID period, which requires close attention in relation to pharmacocorrection methods and comprehensive rehabilitation and further research, including the elucidate the pathogenetic mechanisms of cerebral ischemia.
An Exact Price-Cut-and-Enumerate Method for the Capacitated Multitrip Vehicle Routing Problem with Time Windows
Authors: Yang Yu 
Published: July 2022

We consider the capacitated multitrip vehicle routing problem with time windows (CMTVRPTW), where vehicles are allowed to make multiple trips. The ability to perform multiple trips is necessary for some real-world applications where the vehicle capacity, the trip duration, or the number of drivers or vehicles is limited. However, it substantially increases the solution difficulty in view of the additional trip scheduling aspect. We propose an exact price-cut-and-enumerate method (EPCEM) that solves a novel superstructure-based formulation inspired by Paradiso et al. (2020) . The EPCEM obtains a tight lower bound by an alternating column and row generation method and computes a valid upper bound in the early stage of the algorithm. It obtains an optimal solution and further proves its optimality by a new multiphase sift-and-cut method. Computationally, the EPCEM significantly outperforms the state-of-the-art exact method that only proves optimality for 9 of the 27 test instances with 50 customers. In particular, the EPCEM solves all test instances with up to 70 customers to optimality for the first time and obtains near-optimal solutions with an average optimality gap of no more than 0.3% for instances with 80 to 100 customers. From a practical point of view, solving the CMTVRPTW by the EPCEM yields a solution that, on average, uses at least 45% fewer vehicles and increases the travel cost by no more than 7% compared with the solution to the standard CVRPTW. Supplemental Material: The e-companion is available at https://doi.org/10.1287/trsc.2022.1161 .
The versatility of flowable composites. Part 1: theory and new classification
Authors: AL-Rawas Matheel , Johari Yanti , Yusoff Nazrul M , Mohamad Dasmawati , Husein Adam 
Published: July 2022

The increase in consumer demand for restorative and aesthetic dental treatment has resulted in a gradual upsurge of dental professionals relying on flowable composites (FCs) to meet consumer needs. All main manufacturers in the worldwide dental market offer flowable products together with the packable type. Scientific and technological improvements of FCs properties and handling characteristics have not only seen FCs grow in popularity but resulted in the development of different generations and types of dental FCs suitable for wide range of clinical applications. CPD/Clinical Relevance: It is useful for the dental practitioner to be aware of the classifications, composition and overview of FCs.
Huntington's disease: the role of dentistry in the multidisciplinary team
Authors: Critchley Emma , O'Mahony Finbar , Lemon Elizabeth , Adkins Angela 
Published: July 2022

Huntington's disease is a progressive, genetic disorder, leading to changes to cognition, movement and behaviour. The oral health of these patients can rapidly deteriorate if they are not assessed and managed early. This article explores the role of the dental team, as part of the multidisciplinary team, in caring for Huntington's disease patients. It highlights some of the challenges in providing oral care for this complex group, along with a pathway of care, used by one Special Care Dental Team, in helping to reduce oral complications. CPD/Clinical Relevance: It is important for GDPs to understand the oral health needs of patients with Huntington's disease and their role in supporting the oral health of these patients.
Knowledge deficiency of acute kidney injury management among healthcare professionals: cause for concern?
Authors: Agbo Christopher , Sridharan Sivakumar , Spearpoint Ken , Ashaye Kunle 
Published: July 2022

Background: In 2009, an audit into the death of a patient with a diagnosis of acute kidney injury (AKI) revealed several shortcomings in the management of AKI patients in UK hospitals. The National Confidential Enquiry into Patients Outcome and Death (NCEPOD) reports that the poor management of AKI is commonly related to poor clinical care, and it is recommended that all clinical staff receive regular teaching on AKI to improve their knowledge and skills. Aim: This study aimed to establish the level of understanding of healthcare professionals caring for patients with AKI and ways to provide intervention to overcome any deficiencies. Method: This study used a cross-sectional online questionnaire survey. The questionnaire was posted using the Survey Monkey online tool and sent via a link to healthcare professionals. The links allowed respondents to answer the questions and recorded their anonymised responses. The online survey link was sent out via mail to the staff of three Trusts within Cambridgeshire and Hertfordshire region between May and July 2019. Results: A total of 135 people responded to the survey. A total of 34% (n=46) correctly identified the definition of AKI and correct staging of AKI was 31% (42). A higher number of respondents correctly selected risk factors (85%; n=116), assessments (68%; n=92) and observational information (78%; n=105). There was a statistically significant association between AKI teaching and knowledge of AKI definition, staging and assessment. There was no strong association between AKI teaching and the respondent's ability to recognise risk factors or observation carried out on AKI patients. While there was a slight improvement in individual performance scores against AKI teaching, this was not statistically significant. Conclusion: This study identified specific gaps in knowledge of AKI management among healthcare professionals. An educational intervention will be required to increase AKI management awareness, which may in turn improve the clinical outcomes.