bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient and physician preferences for non-invasive diagnostic cardiovascular imaging technologies: a discrete choice experiment
Authors: Bertrand Thomas , Bartlett-Esquilant Gillian , Fischer Kady , Friedrich Matthias G. 
Published: February 2022

Abstract
Purpose
Diagnostic imaging techniques have to be selected for their accuracy, efficiency, cost-efficiency, and impact on outcome. But beyond that, the choice of non-invasive cardiovascular imaging tests for diagnosing coronary artery disease also has to respect patient safety and comfort. In this study, we investigated patient and physician preference in relation to the choice of cardiovascular imaging tests.

Results
A total of 211 subjects (148 cardiac patients and 63 physicians) were enrolled and completed a discrete choice experiment. Tests and modalities were deconstructed into 6 attributes (risks and side effects, diagnostic accuracy, patient out-of-pocket cost, type of procedure, type of scanner and test duration). A Sawtooth software choice-based conjoint analysis with hierarchical Bayes estimation was performed and showed the risks and side effects attribute was assigned the most relative importance (30%) when considering patients’ preference. Patients gave notably high value to tests with milder side effects, while preferring to avoid exposure to ionizing radiation and risks associated the use of pharmacological agents inducing direct coronary arteriolar vasodilation. Physicians allocated more importance to the patient out-of-pocket cost attribute (29%). Both patients and physicians valued tests’ risks and side effects, diagnostic accuracy, patient out-of-pocket cost as the three most important attributes, but in diverging order. A market simulation comparing current cardiovascular imaging tests revealed breathing maneuver-enhanced cardiac magnetic resonance had the highest shares of preference in both patients (59.6%) and physicians (32.7%).

Conclusion
A patients’ preference for a particular cardiovascular imaging test was most determined by the risks and side effects, while physicians prioritized less costly tests for their patients. In shared decision-making with patients, physicians should therefore focus on a balanced discussion of risks and side effects associated with cardiovascular imaging tests. Both, patients and physicians would prefer a cardiovascular MR imaging test using a vasoactive breathing maneuver instead of currently used alternatives that require intravenous contrast agents, pharmacological stress, or radiation.
Mussaenda macrophylla Wall. exhibit anticancer activity against Dalton’s lymphoma ascites (DLA) bearing mice via alterations of redox-homeostasis and apoptotic genes expression
Authors: Lalremruati Marina , Lalmuansangi C. , Zosangzuali Mary , Tochhawng Lalchhandami , Trivedi Amit Kumar , Kumar Nachimuthu Senthil , Siama Zothan 
Published: February 2022

Abstract
Background
Mussaenda macrophylla is a shrub widely used in Mizo traditional practice for treatment of cancer, fever, cough, ulcer and dysentery. We have previously shown the antioxidant nature of the plant. In this study, we explore the anticancer activity of the aqueous extract of M. macrophylla (MMAE) using Dalton’s lymphoma ascites (DLA) bearing mice as our model.

Results
MMAE significantly inhibited the tumor growth and increased the survival time of the tumor bearing DLA mice. MMAE significantly increased the glutathione (GSH) levels; and glutathione-s-transferase (GST) and superoxide dismutase (SOD) activities. Consistently, MMAE decreased lipid peroxidation levels in DLA mice. Reduced RBC and hemoglobin levels were significantly reversed by MMAE treatment. MMAE also lowers the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatinine (CRE) levels that were otherwise elevated in the DLA control animals. Induction of DNA damage, up-regulation of pro-apoptotic genes and down-regulation of anti-apoptotic genes in DLA bearing mice following MMAE treatment provide an insight into apoptosis based anticancer activities of M. macrophylla.

Conclusion
Our findings demonstrate the role of the aqueous extract of M. macrophylla as a potential anticancer agent possibly targeting the apoptotic pathway.

Graphical Abstract
Treating children with disinhibited social engagement disorder symptoms: Filial therapy
Authors: Hatam S. , Moss S. , Cubillo C. , Berry D. 
Published: February 2022

IntroductionChildren affected by social neglect and other forms of abuse are at significant risk of developing mental health problems as well as social, academic, and behavioral functioning difficulties. Some studies have assessed the effectiveness of treatment for children with trauma-attachment disorder. Nevertheless, some questions remain to be answered regarding appropriate treatment.ObjectivesAim This research identified how filial therapy affects the extent to which foster parents are responsive, sensitive, and attentive to the needs of their children in their care. Subsequently, the study explored how this bond, influenced during filial therapy, affects the signs and symptoms of disinhibited social engagement disorder.MethodsMethod This study used case study as the methodology to research the influence of filial therapy (CPRT) in foster children who show the symptoms of disinhibited social engagement disorder- aged three to six. Two sets of foster parents received a 10-session filial therapy model (CPRT) across 10 weeks. Pre and post measures of the parent-child relationship were analyzed.ResultsResult The findings indicate that filial therapy greatly enhances the bond between foster parents and children with DSEDs. Moreover, these improvements in the bond diminished the symptoms of disinhibited social engagement disorder.ConclusionsConclusion The impact of filial therapy as a responsive intervention reduced the symptoms of disinhibited social engagement disorder. The symptoms have declined very likely as a result of rebuilding, regenerating, and enhancing the relationship between foster children and foster parents.DisclosureNo significant relationships.
Relationship of American Heart Association’s Life Simple 7, Ectopic Fat, and Insulin Resistance in 5 Racial/Ethnic Groups
Authors: Chevli Parag Anilkumar , Mehta Anurag , Allison Matthew , Ding Jingzhong , Nasir Khurram , Blaha Michael J , Blankstein Ron , Talegawkar Sameera A , Kanaya Alka M , Shapiro Michael D , Mongraw-Chaffin Morgana 
Published: February 2022

Abstract

Background
The inverse association between ideal cardiovascular health (CVH) as measured by the American Heart Association’s Life Simple 7 (LS7) and cardiovascular disease (CVD) incidence is well documented. However, research exploring the association between CVH and specific risk factors for cardiometabolic disease is sparse in diverse cohorts.

Methods
This study included 7717 participants from the Mediators of Atherosclerosis in South Asians Living in America and the Multi-Ethnic Study of Atherosclerosis cohorts. We assigned each LS7 component a 0, 1, and 2 and summed these scores to derive an overall CVH score. Visceral, subcutaneous, and intermuscular fat area, pericardial fat volume, and hepatic fat attenuation were measured using noncontrast computed tomography. Multivariable linear regression was used to examine associations between CVH categories and each log-transformed ectopic fat depot, as well as the homeostatic assessment for insulin resistance (HOMA-IR).

Results
In adjusted analysis, compared to those with ideal CVH, participants with poor CVH demonstrated 63.4% (95% CI, 54.3-73.0) higher visceral fat area, 84.0% (95% CI, 76.5-92.1) higher pericardial fat volume, 61.6% (95% CI, 50.7-73.2) higher subcutaneous fat area, and 40.6% (95% CI, 30.2-52.0) higher intermuscular fat area, and 15.1% (95% CI, 13.1-17.2) higher hepatic fat (all Ps &lt; 0.001). Also, poor CVH was associated with 148.2% (95% CI, 131.1-166.7) higher HOMA-IR. We also found significant heterogeneity in the strengths of association by race/ethnicity for each ectopic fat depot.

Conclusion
Poor and intermediate CVH, as defined by LS7 metrics, were associated with significantly higher measures of ectopic fat and insulin resistance among individuals from 5 racial/ethnic groups.
RAS and beyond: the many faces of the neurofibromatosis type 1 protein
Authors: Anastasaki Corina , Orozco Paola , Gutmann David H. 
Published: February 2022

ABSTRACT
Neurofibromatosis type 1 is a rare neurogenetic syndrome, characterized by pigmentary abnormalities, learning and social deficits, and a predisposition for benign and malignant tumor formation caused by germline mutations in the NF1 gene. With the cloning of the NF1 gene and the recognition that the encoded protein, neurofibromin, largely functions as a negative regulator of RAS activity, attention has mainly focused on RAS and canonical RAS effector pathway signaling relevant to disease pathogenesis and treatment. However, as neurofibromin is a large cytoplasmic protein the RAS regulatory domain of which occupies only 10% of its entire coding sequence, both canonical and non-canonical RAS pathway modulation, as well as the existence of potential non-RAS functions, are becoming apparent. In this Special article, we discuss our current understanding of neurofibromin function.
Complicated acute appendicitis in SARS-Cov-2 infected child
Authors: Rzewuska Anna , Żybowska Monika , Sielwanowska Wiktoria , Syzdoł Bartłomiej , Woźniak Magdalena 
Published: February 2022

Wstęp:
Ostre zapalenie wyrostka robaczkowego jest najczęstszą ostrą chorobą jamy brzusznej u dzieci wymagającą leczenia chirurgicznego. Charakteryzuje się ostrym bólem brzucha, wymiotami oraz gorączką. W ostatnim czasie zapalenie wyrostka robaczkowego u dzieci łączone jest z wieloukładową chorobą zakaźną związaną z zakażeniem SARS-Cov-2.
Opis przypadku:
15- letni chłopiec został przyjęty do szpitala z powodu dolegliwości bólowych. W badaniach laboratoryjnych stwierdzono wysoką leukocytozę oraz neutrofilię. Rozpoznano zgorzelinowe, perforowane zapalenie wyrostka robaczkowego z naciekiem kątnicy. Wykonano laparoskopową appendektomię. Dwa dni później w badaniu fizykalnym obecny był obustronnie dodatni objaw Goldflama. Podejrzewano kamicę moczową. W badaniu RTG nie stwierdzono cieni wapiennych w rzucie nerek i dróg moczowych, w prawej jamie opłucnowej stwierdzono obecność płynu. Następnie dołączyła gorączka oraz duszność. Założono drenaż opłucnowy i ewakuowano około 500ml płynu przesiękowego. Otrzymano również dodatni wynik testu PCR na obecność SARS-CoV-2. W kolejnych dniach ewakuowano ponownie około 500ml płynu z jamy opłucnowej. W badaniach laboratoryjnych obserwowano wzrost wskaźników zapalnych. Zmieniono antybiotykoterapię oraz włączono leczenie przeciwzakrzepowe. W badaniach ultrasonograficznych zdiagnozowano ropień w operowanej okolicy, który po kilku dniach uległ samoistnej inwolucji. Chłopiec przestał gorączkować, parametry zapalne stopniowo zmniejszały się. Pacjent również nie zgłaszał dolegliwości ze strony układu oddechowego.
Wnioski:
Analizując powyższy przypadek kliniczny można stwierdzić, że infekcja COVID-19 wpłynęła na przedłużenie hospitalizacji chłopca i mogła przyczynić się do nasilenia powikłań po appendektomii. Należy wziąć pod uwagę wystąpienie wieloukładowego zespołu zapalnego związanego z COVID-19. Warto rozważyć przeprowadzenie testów w kierunku SARS-CoV-2 u dzieci, które mają ciężkie objawy ze strony układu pokarmowego.
Le « Numeruswechsel » dans les témoins hébreux et grecs de Deutéronome 1
Authors: Ausloos Hans 
Published: February 2022

L’échange entre la 2e personne du singulier et la 2e personne du pluriel dans le discours d’adieu de Moïse adressé aux Israélites compte sans doute parmi les caractéristiques les plus énigmatiques du livre du Deutéronome. Cette variation, qui est connue sous le terme technique du « Numeruswechsel » n’a pas encore été étudiée de manière systématique au niveau de la « réception » dans la Septante (LXX).
Dans cette contribution, une analyse est faite de tous les cas du « Numeruswechsel » dans les témoins textuels hébreux (Texte massorétique, Qumran et Pentateuque samaritain) et grecs (LXX) du 1er chapitre du livre du Deutéronome. Elle révèle surtout la complexité du problème, en montrant que le « Numeruswechsel » dépasse la seule variation entre la 2e personne du pluriel et du singulier dans le discours de Moïse aux Israélites.
The Lothian Diary Project: sociolinguistic methods during the COVID-19 lockdown
Authors: Hall-Lew Lauren , Cowie Claire , Lai Catherine , Markl Nina , McNulty Stephen Joseph , Liu Shan-Jan Sarah , Llewellyn Clare , Alex Beatrice , Elliott Zuzana , Klingler Anita 
Published: February 2022

Abstract
The Lothian Diary Project is an interdisciplinary effort to collect self-recorded audio or video diaries of people’s experiences of COVID-19 in and around Edinburgh, Scotland. In this paper we describe how the project emerged from a desire to support community members. The diaries have been disseminated through public events, a website, an oral history project, and engagement with policymakers. The data collection method encouraged the participation of people with disabilities, racialized individuals, immigrants, and low-proficiency English/Scots speakers, all of whom are more likely to be negatively affected by COVID-19. This is of interest to sociolinguists, given that these groups have been under-represented in previous studies of linguistic variation in Edinburgh. We detail our programme of partnering with local charities to help ensure that digitally disadvantaged groups and their caregivers are represented. Accompanying survey and demographic data means that this self-recorded speech can be used to complement existing Edinburgh speech corpora. Additional sociolinguistic goals include a narrative analysis and a stylistic analysis, to characterize how different people engage creatively with the act of creating a COVID-19 diary, especially as compared to vlogs and other video diaries.
Bifurcations and exact traveling wave solutions for the regularized Schamel equation
Authors: Cai Qiue , Tan Kaixuan , Li Jiang 
Published: February 2022

Abstract
In the present paper, we focus on studying the bifurcations and the traveling wave solutions (TWSs) for the regularized Schamel equation. Based on the bifurcation method of a dynamical system, a complete phase portrait analysis is given in various parameter conditions and some novel TWSs with the same energy of the Hamiltonian system are discovered. Various significant results on exact expressions of TWSs, including solitary waves, periodic waves, cusp waves, weak kink waves, loop solitons, compactons in different conditions are obtained.
Association between preventable risk factors and metabolic syndrome
Authors: Al Shehri Hamoud A. , Al Asmari Abdulrahman K. , Khan Haseeb A. , Al Omani Saud , Kadasah Saeed G. , Horaib Ghaleb B. , Al Buraidi Ahmed , Al Sharif Abdullah A. , Mohammed Fayez S. , Abbasmanthiri Rajamohamed , Osman Nasreddien M. 
Published: February 2022

Abstract
The risk factors associated with metabolic syndrome (Met-S) including hypertension, hyperglycemia, central obesity, and dyslipidemia are preventable, particularly at their early stage. There are limited data available on the association between Met-S and preventable risk factors in young adults. We randomly selected 2,010 Saudis aged 18–30 years, who applied to be recruited in military colleges. All the procedures followed the guidelines of International Diabetes Federation. The results showed that out of 2,010 subjects, 4088 were affected with Met-S. The commonest risk factors were high blood sugar (63.6%), high systolic and diastolic blood pressures (63.3 and 37.3%), and high body mass index (57.5%). The prevalence of prediabetes and diabetes were 55.2 and 8.4%, respectively. Obesity, diabetes, hypertension, and hypertriglyceridemia were significantly associated with Met-S. The frequency of smoking was significantly linked with the development of Met-S. The prevalence of Met-S was found to be significantly higher in individuals with sedentary lifestyle. In conclusion, the results of this study clearly indicate that military recruits, who represent healthy young adults, are also prone to Met-S. The findings of this study will help in designing preventive measures as well as public awareness programs for controlling the high prevalence of Met-S in young adults.
Quartic Polynomials with a Given Discriminant
Authors: Klaška Jiří 
Published: February 2022

AbstractLet 0 ≠D∈ ℤ and letQDbe the set of all monic quartic polynomialsx4+ax3+bx2+cx+d∈ ℤ[x] with the discriminant equal toD. In this paper we will devise a method for determining the setQD. Our method is strongly related to the theory of integral points on elliptic curves. The well-known Mordell’s equation plays an important role as well in our considerations. Finally, some new conjectures will be included inspired by extensive calculations on a computer.
Multidimensional engineered metasurface for ultrafast terahertz switching at frequency-agile channels
Authors: Hu Yuze , Tong Mingyu , Hu Siyang , He Weibao , Cheng Xiang’ai , Jiang Tian 
Published: February 2022

Abstract
The ability to actively manipulate free-space optical signals by using tunable metasurfaces is extremely appealing for many device applications. However, integrating photoactive semiconductors into terahertz metamaterials still suffers from a limited functionality. The ultrafast switching in picosecond timescale can only be operated at a single frequency channel. In the hybrid metasurface proposed here, we experimentally demonstrate a dual-optically tunable metaphotonic device for ultrafast terahertz switching at frequency-agile channels. Picosecond ultrafast photoswitching with a 100% modulation depth is realized at a controllable operational frequency of either 0.55 THz or 0.86 THz. The broadband frequency agility and ultrafast amplitude modulation are independently controlled by continuous wave light and femtosecond laser pulse, respectively. The frequency-selective, temporally tunable, and multidimensionally-driven features can empower active metamaterials in advanced multiplexing of information, dual-channel wireless communication, and several other related fields.
Experimental and computational study of rafoxanide radioiodination via isotopic exchange reaction
Authors: Hussien Heba , Khater Sabah I. , Rashad Ahmed M. 
Published: February 2022

Abstract
The current study is an attempt to confirm the possibility of using rafoxanide (Raf) for diagnostic or radiotherapeutic purpose based on the radioiodine used in the labeling process. The isotopic exchange reaction was performed to radiolabel Raf. The maximum radiochemical yield of [125I]Raf (90%) was obtained when 20 μL of Na[125I]I (7.4 MBq (200 μCi)) in the reaction flask was added to 100 μg of Raf (0.799 mM) within 20 min at 140 °C. High pressure liquid chromatography was used to purify the labeled product of [125I]Raf. The activation energy was calculated experimentally in both ethyl acetate and methanol as reaction medium and found to be 22.82 kJ/mol and 24.43 kJ/mol, respectively. Furthermore, Gaussian 09 used the density function theory (DFT) to calculate the activation energy of the reaction in the two solvents.
KEEFEKTIFAN MATERI AJAR PENYANGGA BERBASIS PEMECAHAN MASALAH PADA KEMAMPUAN BERPIKIR KREATIF SISWA
Authors: Putri Syarafina Dirinda , Wijayati Nanik , Mahatmanti F. Widhi , Rachmadiyono Dwi 
Published: February 2022

Penelitian ini bertujuan untuk mengetahui keefektifan dan tanggapan siswa terhadap materi ajar larutan penyangga berbasis pemecahan masalah untuk kemampuan berpikir kreatif siswa kelas XI SMA Negeri 1 Wonogiri. Metode penelitian yang digunakan adalah eksperimen dengan desain penelitian only posttest control design. Teknik sampling yang digunakan yaitu cluster random sampling dengan syarat data populasi berdistribusi normal dan homogenitas. Didapatkan hasil pemilihan sampel yaitu kelas XI MIPA 2 sebagai kelas eksperimen dan kelas XI MIPA 3 sebagai kelas kontrol. Teknik analisis yang digunakan yaitu uji perbedaan dua rata-rata. Hasil penelitian diperoleh perhitungan bahwa kedua kelas berdistribusi normal Â dan perhitungan perbedaan dua rata-rata diperoleh sebesar 3,94 yang menunjukkan bahwa kelas eksperimen lebih baik daripada kelas kontrol. Untuk rata-rata tiap indikator berpikir kreatif diperoleh 66% untuk kelas eksperimen dan 54% untuk kelas kontrol pada Fluency, pada Flexibility diperoleh 67% untuk kelas eksperimen dan 60% untuk kelas kontrol. Untuk Originality 56% untuk kelas eksperimen dan 59% untuk kelas kontrol, kemudian Elaboration 61% untuk kelas eksperimen dan 60% untuk kelas kontrol. Berdasarkan hasil penelitian dapat didismpulkan bahwa materi ajar berbasis pemecahan masalah efektif terhadap kemampuan berpikir kreatif siswa kelas XI SMA Negeri 1 Wonogiri pada materi larutan penyangga.
Evaluación bibliométrica y temática de revistas incluidas en el Scimago Journal Rank
Authors: Gregorio-Chaviano Orlando , López-Mesa Evony Katherine , Zamora María-Consuelo 
Published: February 2022

El objetivo de la presente investigación es analizar las revistas colombianas de educación incluidas en el Scimago Journal Rank (SJR), utilizando indicadores bibliométricos y criterios de calidad editorial, que permitan conocer tendencias y comportamientos tanto desde la perspectiva bibliométrica como de gestión. Se realizó una búsqueda de toda la información registrada por cada revista en la base de datos Scopus y luego de un proceso de limpieza se obtuvieron indicadores de producción, citación y redes, así como el análisis de la endogamia, capacidad de atracción y otras variables.
Como principales resultados se destacan el bajo promedio de citas por documento y de SJR (indicador de prestigio), un 10% de autocitación y revistas con más del 20% de endogamia, junto a una alta participación internacional en las contribuciones. En cuanto a las citas recibidas, estas provienen de revistas del propio ámbito y distribuidas en los distintos cuartiles de forma homogénea. A nivel general, la metodología utilizada aporta elementos sobre el estado y evolución de las revistas seleccionadas, que igualmente puede ser aplicada al estudio de otras revistas.