bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Pengelolaan Sampah di Tempat Pembuangan Akhir (TPA) Desa Sido Makmur Kecamatan Sipora Utara
Authors: Agung Kristian , Juita Erna , Zuriyani Elvi 
Published: March 2022

Sampah merupakan suatu hal yang selalu ada dalam kehidupan sehari-hari. Semua yang beraktivitas pasti akan menghasilkan sampah dan begitu juga yang terjadi di Desa Sido Makmur Kecamatan Sipora Utara.
Permasalahan dari penelitian ini adalah mengetahui pengelolaan sampah dari berbagai teknik, seperti: teknik opersional, ekonomi, kelembagaan dan peran serta masyarakat. Tujuan dari penelitian ini adalah untuk mengetahui sistem pengelolaan sampah dan peran serta masyarakat yang ada di Desa Sido Makmur Kecamatan Sipora Utara. Metode penelitian yang digunakan adalah penelitian deskriptif kualitatif. Teknik penelitian yang dilakukan dengan wawancara, peneyerahan angket atau kuesioner dan dokumtasi. Partisipan yang digunakan dalam penelitian ini adalah perwakilan dari Dinas Lingkungan Hidup dan Kebersihan, Perwakilan pengelolaa TPA, tenaga kebersihan dan kepala desa.
Hasil penelitian menyatakan bahwa pengelolaan sampah di Desa tersebut masih kurang baik hal ini di sebabkan oleh berbagai faktor, seperti: fasilitas sarana dan prasarana yang masih belum baik dan tingkat kesadaran masyarakat yang masih rendah akan pentingnya pengelolaan sampah dengan baik dan benar. Saran yang bisa diberikan adalah dengan melakukan sosialisasi tentang pengelolaan sampah yang baik dan benar, jadwal rutin gotong royong baik dari pihak masyarakat ataupun dari Desa dan Dinas yang bersangkutan
Hubungan antara Minat dengan Hasil Belajar Kartografi
Authors: Adiputra Chandra 
Published: March 2022

Penelitian ini dilakukan untuk menganalisis hubungan antara minat dengan hasil belajar mata kuliah Kartografi. Mata kuliah ini dikontrak oleh 19 peserta didik Pendidikan IPS pada semester genap tahun akademik 2020/2021. Data terdiri atas minat terhadap mata kuliah Kartografi (angket) serta hasil belajar mata kuliah Kartografi aspek pengetahuan dan keterampilan (studi dokumentasi). Tidak ada hubungan antara minat dengan hasil belajar Kartografi, baik hasil belajar aspek pengetahuan (rhitung ≤ rtabel = 0,0583 ≤ 0,4555 (n = 17; α = 0,05)) maupun keterampilan (-ttabel ≤ t0 ≤ ttabel = -2,11 ≤ 0,88 ≤ 2,11 (n = 17; ½α = 0,025)). Dengan demikian, peserta didik yang memiliki minat tinggi terhadap mata kuliah Kartografi, belum tentu hasil belajar Kartografinya akan tinggi pula (begitu pun sebaliknya), baik hasil belajar aspek pengetahuan maupun keterampilan. Namun, hasil penelitian ini tidak dapat digeneralisasikan apabila ditinjau dari minat, karena data minat diketahui tidak bervarian homogen (F > F critical one-tail = 1.441,30 > 2,27).

This research was conducted to analyze the relationship between interest and learning outcomes of Cartography courses. This course is contracted by 19 Social Studies Education students in the even semester of the 2020/2021 academic year. The data consists of interest in Cartography courses (questionnaire) and learning outcomes of the Cartography course aspect of knowledge and skills (documentation studies). There is no relationship between interest and learning outcomes of Cartography, both learning outcomes aspect of knowledge (rcount ≤ rtable = 0,0583 ≤ 0,4555 (n = 17; α = 0,05)) and skills (-ttabel ≤ t0 ≤ ttabel = -2,11 ≤ 0,88 ≤ 2,11 (n = 17; ½α = 0,025)). Thus, students who have a high interest in Cartography courses do not necessarily have high Cartography learning outcomes (and vice versa), both learning outcomes aspect of knowledge and skills. However, the results of this study cannot be generalized in terms of interest, because interest data is known to have no homogeneous variance (F > F critical one-tail = 1.441,30 > 2,27).
Continuously processing waste lignin into high-value carbon nanotube fibers
Authors: Liu Fuyao , Wang Qianqian , Zhai Gongxun , Xiang Hengxue , Zhou Jialiang , Jia Chao , Zhu Liping , Wu Qilin , Zhu Meifang 
Published: March 2022

Abstract
High value utilization of renewable biomass materials is of great significance to the sustainable development of human beings. Because biomass contains large amounts of carbon, they are ideal candidates for the preparation of carbon nanotube (CNT) fibers. However, continuous preparation of CNT fibers using biomass as carbon source remains a huge challenge due to the complex chemical structure of biomass. Here, we develop high-performance CNT fibers from lignin by solvent dispersion, high-temperature pyrolysis, catalytic synthesis, and assembly, and realize continuous preparation of CNT fibers. The CNT fibers exhibit a tensile strength of 1.35 GPa and an electrical conductivity of 6.28×105 S m− 1, superior to that of most biomass-derived carbon materials. More importantly, we achieve an unprecedented continuous production of CNT fibers from biomass with a production rate of 120 m h− 1. Our preparation method is extendable to other biomass materials and will greatly promote the high value application of biomass in a wide range of fields.
Synthesis and comparative assessment of ESIPT core containing lightfast fluorescent monoazo dyes
Authors: Ramugade Supriya H , Nethi Sekar Nagaiyan 
Published: March 2022

Abstract
Four fluorescent monoazo dyes were synthesized from “4-amino-2-(benzo[d]oxazol-2-yl) phenol” and “5-amino-2-(benzo[d]oxazol-2-yl) phenol.” The ESIPT core is incorporated in the dyes to enhance the lightfastness/photostability. These dispersed dyes were characterized by 1H NMR, FT-IR, mass, and CHN analysis. The various properties of fastness, XRD analysis, particle size analysis by comparing conventional method(C) versus nanoemulsion method (N) on polyester fabric with reduced liquor ratio were performed. Electrophilicity index was calculated and correlated with light fastness properties on polyester by both methods. Both methods observed higher electrophilicity index (6–7) and lightfastness properties (6–7) for all the dyes. The nanoemulsion dye "Z-2-(benzo [d] oxazol-2-yl) − 5 - (4-(diethylamino) – 2 - hydroxyphenyl) diazenyl) phenol" has the largest particle size distribution (55 nm). The HOMO-LUMO energy gap for the dye 6aA is the largest, as shown by density functional theory (DFT) investigations, further confirmed by its highest electrochemical values obtained from cyclic voltammetry.
Heat shock transcription factor 2 promotes mitophagy of intestinal epithelial cells through PARL/PINK1/Parkin pathway in ulcerative colitis
Authors: Liang Hao , Zhang Fengrui , Wang Wen , Zhao Wei , Zhou Jiao , Feng Yuran , Wu Jing , Li Maojuan , Bai Xinyu , Zeng Zhong , Niu Junkun , Miao Yinglei 
Published: March 2022

Abstract
Objective and backgroundThe overactivation of NLRP3 inflammasome is a critical factor for ulcerative colitis (UC). We found that heat shock transcription factor 2 (HSF2), which is highly expressed in UC, could inhibit the activation of NLRP3 inflammasome and reduce IL-1β in intestinal epithelial cells(IECs), but the mechanisms were still unclear. We aimed to elucidate the mechanisms of HSF2 inhibiting the activation of NLRP3 inflammasome of IECs.MethodsTEM was used to detect the number of damaged mitochondria and the level of mitophagy in intestinal mucosa of UC patients, healthy controls, mice and Caco-2 cells. ROS levels were detected by immunofluorescence or flow cytometry. RT-PCR, WB and immunohistochemistry were used to detect the level of PARL, PINK1 and Parkin.ResultsThe levels of mitophagy and ROS in intestinal mucosa of UC patients were positively correlated with disease activity. In IECs, after downregulation of HSF2, mitophagy reduced and number of damaged mitochondria and ROS increased, while overexpression of HSF2 showed opposite results. In addition, HSF2 might regulate mitophagy through PARL/PINK1/Parkin signaling pathway.ConclusionsHSF2 may promote mitophagy and decrease the level of mtROS through the PARL/PINK1/Parkin signaling pathway, which might be a potential mechanism of HSF2 inhibiting inflammation in UC.
Genome-wide mapping of oncogenic pathways and genetic modifiers of chemotherapy using a high-risk hepatoblastoma genetic model
Authors: Fang Jie , Singh Shivendra , Natarajan Sivaraman , Tillman Heather , Abuzaid Ahmed , Durbin Adam , Lee HaWon , Wu Qiong , Steele Jacob , Connelly Jon , Cheng Changde , Jin Hongjian , Chen Wenan , Fan Yiping , Pruett-Miller Shondra , Rehg Jerold , Emmons Joseph , Cairo Stefano , Wang Ruoning , Glazer Evan , Murphy Andrew , Chen Taosheng , Davidoff Andrew , Easton John , Chen Xiang , Yang Jun 
Published: March 2022

Abstract
A lack of relevant genetic models and cell lines hampers our understanding of hepatoblastoma pathogenesis and the development of new therapies for this neoplasm. We report a liver-specific MYC-driven hepatoblastoma murine model that faithfully recapitulates the pathological features of mixed fetal and embryonal hepatoblastoma, with transcriptomics resembling the high-risk gene signatures of the human disease. Single-cell RNA-sequencing and spatial transcriptomics identified distinct subpopulations of hepatoblastoma cells. After deriving cell lines from the mouse model, we mapped the cancer dependency genes using CRISPR-Cas9 screening and identified druggable targets shared with human hepatoblastoma (i.e., CDK7, CDK9, PRMT1, PRMT5). Our screen also revealed oncogenes and tumor suppressor genes in hepatoblastoma that engage multiple, druggable cancer signaling pathways. Chemotherapy is critical for human hepatoblastoma treatment. A genetic mapping of doxorubicin response by CRISPR-Cas9 screening identified modifiers whose loss-of-function synergizes with (e.g., PRKDC) or antagonizes (e.g., apoptosis genes) with the effect of chemotherapy. The combination of PRKDC inhibition and doxorubicin-based chemotherapy greatly enhances therapeutic efficacy. These studies have provided a useful set of resources including disease models suitable to identify and validate potential therapeutic targets in human high-risk hepatoblastoma.
Emotion Control Training Enhances Reappraisal Success Among Individuals With Reported ADHD Symptoms
Authors: Hamerman Revital , Cohen Noga 
Published: March 2022

Abstract
Previous research indicates that training individuals to recruit cognitive control before exposure to negative pictures can facilitate the propensity to use reappraisal and reappraisal success. Individuals with attention deficit hyperactivity disorder (ADHD) experience difficulties in cognitive control and emotion regulation, so they may especially benefit from such training. Individuals reporting high ADHD symptoms and controls were randomly assigned to one of two training conditions. In the high emotion control (H-EC) training condition, negative pictures were typically preceded by a stimulus that recruits cognitive control. In contrast, in the low emotion control (L-EC) training condition, negative pictures were typically preceded by a stimulus that does not recruit cognitive control. Participants were then asked to recall an adverse personal event and to reappraise the event. As predicted, instructed reappraisal was more effective in reducing negative mood in the H-EC training compared to the L-EC training. Furthermore, compared to controls, individuals with reported ADHD symptoms showed a greater propensity to use reappraisal after writing the event and a more considerable reduction in event significance and negativity following the instructed reappraisal assignment. We argue that employing cognitive control over emotional information has a causal role in reappraisal use and success among individuals with ADHD symptoms.
Diabetic foot infection caused by Burkholderia cepacia complex: Report of an unusual case and a scoping review
Authors: Leme Rodrigo Cuiabano Paes , Chaves Jéssica Reis Esteves , Gonçalves Luiz Carlos Soares , Alvim Leonardo César , de Almeida João Roberto Chaves , Renó Leonardo da Cruz 
Published: March 2022

Abstract
Burkholderia cepacia complex (BCC) is a widespread Gram-negative bacillus organized into more than 20 phylogenetically bacterial species. According to previous publications, BCC species are widely described pathogens in patients with cystic fibrosis (CF) but not in individuals with diabetes mellitus (DM). This study presents a case report of a diabetic foot infection (DFI) caused by BCC in a 42-year-old male patient hospitalized after an antibiotic treatment failure and the recommended drugs by the hospital. The patient improved after two surgical debridement procedures and a high-dose extended infusion (EI) of meropenem. The team of vascular surgeons and the infectologist worked fervently to solve the case. Finally, a scoping review was constructed to map the BCC infections in patients with DM.
Intimate partner violence and associated factors among reproductive age women in Liberia: Further analysis of recent Liberian demographic and health survey
Authors: Tsegaw Menen , Mulat Bezawit , Shitu Kegnie 
Published: March 2022

Abstract
Background: Intimate Partner Violence (IPV) is a major public health problem and a violation of women's human rights, almost one third of women aged 15-49 years who have been in a relationship have experienced to some form of physical and/or sexual violence by their intimate partner worldwide.Objective: The study aimed to assess intimate partner violence and associated factors among reproductive -age women in Liberia. Method: This study was based on a large community-based cross-sectional survey, Liberia Demographic Health Survey (LDHS), conducted From October 16, 2019, to February 12, 2020, in Liberia. The 2019–20 LDHS used a stratified two-stage cluster design. Multivariable logistic regression was used to identify independent intimate partner violence among reproductive age women in Liberia and to control confounders. Adjusted odds ratio and confidence interval (CI) were used to declare statistical significance in the final model. Those variables with p-value<0.05 was considered as statistically significant.Result: The overall prevalence of IPV was 44.74% (42.73, 46.77). Older age (AOR=0.86 (95%CI: 0.81, 0.91)), south central region (AOR=0.71(95%CI: 0.52, 0.96)), women’s primary education (AOR=1.28 (95%CI: 1.01, 1.63)), female household head (AOR=0.77 (95%CI: 0.61, 0.97)) ,husbands higher education (AOR=0.62(95%CI: 0.39, 0.99)) ,positive wife beating attitude (AOR=1.57 (95%CI: 1.29, 1.90)) ,husband drinks (AOR=2.59 (95%CI: 2.14, 3.15)) and Women’s decision making autonomy (AOR=0.75 (95%CI: 0.61, 0.93)) were significantly associated with IPV.Conclusion: The prevalence of IPV in Liberia was high. Socio-demographic characteristics of women, husbands education, sex of household head, having a positive attitude towards wife-beating, partner’s alcohol drinking habit and women empowerment was significantly associated with IPV in Liberia. Policymakers and program designers have to take into account those factors when they design interventions to reduce IPV in Liberia.
A novel splice site variant c.1183+1 G&gt;C in DFNA5 causing autosomal dominant nonsyndromic hearing loss in a Chinese Family
Authors: Li Qiong , Wang Shujuan , Liang Pengfei , Li Wei , Wang Jian , Fan Bei , Yang Yang , An Xiaogang , Chen Jun , Zha Dingjun 
Published: March 2022

Abstract
BackgroundThe major clinical manifestation of autosomal dominant nonsyndromic hearing loss (ADNSHL) is bilateral, symmetrical, postlingual progressive sensorineural hearing loss, which begins with impairment at high frequencies and eventually progresses to hearing loss at all frequencies. Autosomal dominant deafness-5 (DFNA5) is a subtype of ADNSHL caused by a heterozygous variant in the gasdermin E (GSDME, also known as DFNA5) gene. MethodsTargeted genomic capture and sequencing were performed on the proband of a six-generation Chinese family with hearing loss. The co-segregation analysis between the hearing loss and the novel variant was analyzed by Sanger sequencing and pure-tone audiometry. The minigene splicing assay was performed to evaluate the potential effect of the variant on messenger RNA splicing in vitro. ResultsThe family exhibited autosomal dominant, progressive, postlingual, nonsyndromic sensorineural hearing loss, which was similar to the previously reported DFNA5 families. A novel heterozygous splice site variant in GSDME gene intron 8 was identified as “Likely pathogenic” according to the American College of Medical Genetics and Genomics (ACMG) guidelines, which co-segregated with the hearing loss phenotype of the family. The variant caused skipping of exon 8 in the mutant transcript, leading to the direct linking of exon 7 and 9.ConclusionsWe identified a novel GSDME splice site variant c.1183+1 G>C in an extended Chinese family, which led to the skipping of exon 8, through targeted genomic capture and sequencing and co-segregation analysis. The results extended the pathogenic variant spectrum of the GSDME gene, provided further support for the “gain-of-function” mechanism of DFNA5, and afforded a molecular interpretation for these patients with ADNSHL.
Monitoring The Land Surface Temperature And Its Correlation With NDVI Of Chiniot By Using GIS Technology And Remote Sensing
Authors: Yaseen Ahmed , Khan Aleeza 
Published: March 2022

Abstract
The unplanned and rapid increased in unban area have changed the atmospheric conditions and the non-urban area have less warm as compare to urban areas. In study area little portion of Chenab River include and the river bed contains the sand it shows high temperature value due to its specific heat energy. For this study Landsat-5(February2000), Landsat-7(February 2005,2010) and Landsat-8(Feb2015, Feb2020, Feb2022) acquired from USGS. The LST and NDVI correlation is negative and it is clearly seen that in the analysis of Landsat-8(OLI/TIRS) the Land Surface Temperature is increases 3.5408oC from 2015 to 2022. The analysis of Landsat-7(ETM+) the Land Surface Temperature is increases 3.3461oC from 2005 to 2010. In the Correlation analysis(LST&NDVI) the most of vegetation occurs between 11 oC to 28 oC.
The Application of Remote Sensing Technology in Forestry Carbon Sequestration
Authors: Tian Qimin 
Published: March 2022

Abstract
Forests absorb a great deal of carbon from the atmosphere every year and are strategically important for climate change mitigation. To better analyze the carbon sequestration value of forests, We established a carbon sequestration model. A net ecosystem productivity remote sensing map model was established based on the remote sensing idea of spatial informatics, which was used to measure the carbon sequestration capacity of forests. In addition, we measured the carbon sequestration of forests on each continent during the decade from 2003 to 2012, and compared the results to summarize the characteristics of good forest management. In order to better study the change of forest carbon sequestration over time and optimize the forest management plan, we selected the Greater Khingan Mountains in China as the research object. The Grey Prediction Model was established to predict the carbon sequestration model of the forest in the next 100 years. The results showed that Greater Khingan Mountains forest could sequestrate 167,996,510.3t/a carbon in the next 100 years.
The quality of life of children facing life limiting conditions and of their parents in Belgium: a cross sectional study
Authors: Friedel Marie , Aujoulat Isabelle , Brichard Bénédicte , Fonteyne Christine , Renard Marleen , Degryse Jean-Marie 
Published: March 2022

Abstract
Background: Paediatric palliative care (PPC) aims to improve the quality of life of children, however, this objective is rarely measured in clinical care. PPC is provided in Belgium through 6 transmural paediatric liaison teams (PLTs) ensuring continuity of care for children with life-limiting or life-threatening conditions (LLC/LTC). This study aims to measure the quality of life (QoL) of children with LLC/LTC monitored by PLT and the QoL of their parents.Methods: During interviews with children and parents, an original sociodemographic questionnaire, the Children Palliative Outcome Scale – version 2 (CPOS-2), the Fragebogen für Kinder und Jugendliche zur Erfassung der gesundheitsbezogenen Lebensqualität (KINDL) and the Quality of Life in Life-threatening Illness-Family Caregivers (QOLLTI-F) were completed by PLT members. Descriptive statistics were conducted on the sociodemographic data and the CPOS-2 and QOLLTI-F scores. The association between clinicians’ judgement of QoL and the scores on the QOLLTI-F and CPOS-2 was explored using Spearman’s correlation coefficients and boxplots. Pearson’s chi square test and Fisher’s exact test were used to investigate significant differences between scores. The results were discussed and interpreted with 6 PLTs.Results: Seventy-three children aged 1-18 years were included in the study. For items focused on emotional well-being, children reported that their QoL was higher than that of their parents. The QoL scores were not significantly associated with the severity of the child’s condition. Discrepancies were not found between health care professionals’ perceptions and parents’ perceptions of their QoL, as measured by the CPOS-2.Conclusion: This study provides, for the first time, an overview of the QoL of children and parents followed-up by PLT in Belgium.
Fully automatic landmarking of 2D photographs identifies novel genetic loci influencing facial features
Authors: Li Qing , Chen Jieyi , Faux Pierre , Bonfante Betty , Fuentes-Guajardo Macarena , Mendoza-Revilla Javier , Chacón-Duque Juan , Hurtado Malena , Villegas Valeria , Granja Vanessa , Jaramillo Claudia , Arias William , Barquera Rodrigo , Everardo-Martínez Paola , Sánchez-Quinto Mirsha , Gómez-Valdés Jorge , Villamil-Ramírez Hugo , de Cerqueira Caio C. Silva , Hünemeier Tábita , Ramallo Virginia , Wu Sijie , Du Siyuan , Gonzalez-José Rolando , Schüler-Faccini Lavinia , Bortolini Maria-Cátira , Acuña-Alonzo Victor , Canizales-Quinteros Samuel , Gallo Carla , Poletti Giovanni , Rojas Winston , Rothhammer Francisco , Navarro Nicolas , Wang Sijia , Adhikari Kaustubh , Ruiz-Linares Andrés 
Published: March 2022

Abstract
We report a genome-wide association study for facial features in > 6,000 Latin Americans. We placed 106 landmarks on 2D frontal photographs using the cloud service platform Face++. After Procrustes superposition, genome-wide association testing was performed for 301 inter-landmark distances. We detected nominally significant association (P-value < 5×10− 8) for 42 genome regions. Of these, 9 regions have been previously reported in GWAS of facial features. In follow-up analyses, we replicated 26 of the 33 novel regions (in East Asians or Europeans). The replicated regions include 1q32.3, 3q21.1, 8p11.21, 10p11.1, and 22q12.1, all comprising strong candidate genes involved in craniofacial development. Furthermore, the 1q32.3 region shows evidence of introgression from archaic humans. These results provide novel biological insights into facial variation and establish that automatic landmarking of standard 2D photographs is a simple and informative approach for the genetic analysis of facial variation, suitable for the rapid analysis of large population samples.