bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multi‐Mode, Multi‐Frequency Dielectric Elastomer Actuator
Authors: Gratz‐Kelly Sebastian , Rizzello Gianluca , Fontana Marco , Seelecke Stefan , Moretti Giacomo 
Published: June 2022

AbstractThis paper presents a principle to develop multi‐function dielectric elastomer actuators (DEAs) that can concurrently accomplish linear actuation and sound generation through a single electrical input. A centimeter‐scale cone‐shaped DEA is fabricated using silicone‐based dielectric and electrodes. Measurements of the vibro‐acoustic response reveal that the pumping deformation of the DEA contributes to a negligible extent in the sound generation, which is hence ascribable to higher order structural modes whose frequency pass‐band is highly uncoupled from that of the pumping mode. Exciting the DEA with a multi‐chromatic input voltage allows achieving strokes close to 1 mm or blocking forces over 0.5 N, while simultaneously generating sound pressure levels over 60 dB, regardless of possible forces and/or mechanical constraints on the DEA pumping motion. The ability of the DEA to concurrently generate linear actuation and sound is demonstrated via proof‐of‐concept tests: the DEA can reproduce music, while at the same time generating a deformation pulse or lifting a load comparable with its own blocking force. Furthermore, measuring the current generated by the DEA allows detecting deformations impressed by the exterior and use the DEA as an active audio‐tactile interface, which produces a combined vibro‐acoustic stimulus in response to a user's touch.
Stretch‐Activated Reprogrammable Shape‐Morphing Composite Elastomers
Authors: Tang Jiali , Chen Zheqi , Cai Yiting , He Jin , Luo Yingwu 
Published: June 2022

AbstractA stretched elastomer film generally will recover its original flat shape after releasing the applied force due to elasticity. Here, stretch‐activated flat‐to‐3D shape‐morphing composite elastomers by local mismatches of elasticity and plasticity, is reported. The elasticity/plasticity in a flat conventional elastomer film is spatially regulated by local swelling of a melted small molecule which is crystallizable at room temperature. Being released from a stretch, the patterned flat composite elastomer films transform into preset complex 3D shapes. Importantly, the shape‐morphing is reversible, reprogrammable, and predictable, which provides a versatile and sustainable platform for the design of soft morphing devices.
Effects of gas concentration on hydrodynamics of gas absorption in a microchannel
Authors: Jiang Bin , Jiang Shaokun , Zhu Chunying , Ma Youguang , Fu Taotao 
Published: June 2022

AbstractIn this article, the effects of gas concentration on hydrodynamics of gas–liquid two‐phase flow with mass transfer during gas absorption in a microchannel are investigated, by using 2‐amino‐2‐methyl‐1‐propanol (AMP) solution to absorb mixtures of CO2 and N2 with various volume fractions. The concentration of CO2 not only affects the driving force of gas–liquid mass transfer, but also affects the pressure drop of gas–liquid two‐phase flow. The average linear velocity of the liquid phase is estimated by introducing the void fraction, which accurately characterizes the difference in the bubble velocity versus the liquid velocity. On this basis, the pressure drop model of gas–liquid two‐phase flow with mass transfer in a microchannel is established. Through the pressure drop model, the influence mechanism of CO2 concentration on the pressure drop during gas absorption in a microchannel is revealed.
Biosynthesis of Sordarin Revealing a Diels–Alderase for the Formation of the Norbornene Skeleton
Authors: Liu Shuang He , Sun Jia Li , Hu Yi Ling , Zhang Li , Zhang Xuan , Yan Zhang Yuan , Guo Xing , Guo Zhi Kai , Jiao Rui Hua , Zhang Bo , Tan Ren Xiang , Ge Hui Ming 
Published: June 2022

AbstractSordarin (1) is a fungal diterpene glycoside that displays potent antifungal bioactivity through inhibition of elongation factor 2. The structures of sordarin and related compounds feature a highly rearranged tetracyclic diterpene core. In this study, we identified a concise pathway in the biosynthesis of sordarin. A diterpene cyclase (SdnA) generates the 5/8/5 cycloaraneosene framework, which is decorated by a set of P450s that catalyze a series of oxidation reactions, including hydroxylation, desaturation, and C−C bond oxidative cleavage, to give a carboxylate intermediate with a terminal alkene and a cyclopentadiene moiety. A novel Diels–Alderase SdnG catalyzes an intramolecular Diels–Alder (IMDA) reaction on this intermediate to forge the sordarin core structure. Subsequent methyl hydroxylation and glycosylation complete the biosynthesis of sordarin. Our work discloses a new strategy used by nature for the formation of the rearranged diterpene skeleton.
Aptamer‐Array‐Guided Protein Assembly Enhances Synthetic mRNA Switch Performance
Authors: Lu Qiuyu , Hu Yaxin , Yin Li Cheuk , Kuang Yi 
Published: June 2022

AbstractSynthetic messenger RNA (mRNA) switches are powerful synthetic biological tools that can sense cellular molecules to manipulate cell fate. However, their performances are limited by high output signal noise due to leaky output protein expression. Here, we designed a readout control module that disables protein leakage from generating signal. Aptamer array on the switch guides the inactive output protein to self‐assemble into functional assemblies that generate output signal. Leaky protein expression fails to saturate the array, thus produces marginal signal. In this study, we demonstrated that switches with this module exhibit substantially lower signal noise and, consequently, higher input sensitivity and wider output range. Such switches are applicable for different types of input molecules and output proteins. The work here demonstrates a new type of spatially guided protein self‐assembly, affording novel synthetic mRNA switches that promise accurate cell manipulation for biomedical applications.
Putting climate change at the heart of education: Is England's strategy a placebo for policy?
Authors: Dunlop Lynda , Rushton Elizabeth A. C. 
Published: June 2022

AbstractIn this paper we present an analysis of the sustainability and climate change strategy for education and children's services systems in England, produced by the Department for Education. Using critical discourse analysis, we juxtapose qualitative data collected from >200 youth teachers and teacher educators in the context of co‐creating a manifesto for education and environmental sustainability. Through analysis of these two datasets, we evaluate the government's proposals for climate education and sustainability. We find that the strategy foregrounds economic concerns, with educational priorities driven by the ‘net zero’ policy agenda, and an over‐reliance on increased science‐focused knowledge and skills. The strategy suggests an absence of governmental responsibility and attention to the political dimensions of climate change. This is in contrast to stakeholder perspectives which see economic priorities as part of the problem and call for pro‐environmental action at all levels, including from policymakers. The strategy has a depoliticising effect as it introduces additional demands for teachers and schools without the associated enabling policy environment. We argue that the strategy runs the risk of becoming a placebo for policy, with the appearance of ‘doing something’ whilst failing to address the fundamental policy problem.
Auszugtragfähigkeit von dünnen Verbunddübeln als Verbindungsmittel in Stahlbetonwandtafeln
Authors: Penkert Fabian , Pahn Matthias 
Published: June 2022

AbstractSteigende Anforderungen an den Wärmeschutz und die Reduzierung von Transmissionswärmeverlusten an Gebäuden führen zu einem erhöhten Bedarf an energieeffizienten Dämmsystemen und Technologien für die Gebäudehülle. Im Rahmen dieses Beitrags werden mit dünnen Verbunddübeln neuartige Verbindungsmittel für ein effizientes vakuumgedämmtes Wandelement vorgestellt. Dieses Element besteht aus zwei Betonschalen und einer vakuumgedämmten Kernschicht. Die Kopplung der einzelnen Schichten erfolgt über dünne Verbunddübel, die als Verbindungsmittel für Stahlbetonwandtafeln eingesetzt werden. In Auszugversuchen wird das Last‐Verformungs‐Verhalten von dünnen puzzleförmigen Verbunddübeln untersucht und der Einfluss verschiedener Parameter wie der Bewehrung, der Einbindetiefe und der Verbunddübelanzahl herausgestellt. Die Versuchsergebnisse werden mit einem bestehenden Modell aus der Literatur zur Bestimmung der Auszugtragfähigkeit von Verbunddübeln verglichen und bewertet. Darauf aufbauend wird ein modifiziertes Modell zur Beschreibung der Auszugtragfähigkeit von dünnen Verbunddübeln vorgestellt und anhand der Versuchsergebnisse validiert.
A unified framework for weighted parametric group sequential design
Authors: Anderson Keaven M. , Guo Zifang , Zhao Jing , Sun Linda Z. 
Published: June 2022

AbstractGroup sequential design (GSD) is widely used in clinical trials in which correlated tests of multiple hypotheses are used. Multiple primary objectives resulting in tests with known correlations include evaluating (1) multiple experimental treatment arms, (2) multiple populations, (3) the combination of multiple arms and multiple populations, or (4) any asymptotically multivariate normal tests. In this paper, we focus on the first three of these and extend the framework of the weighted parametric multiple test procedure from fixed designs with a single analysis per objective to a GSD setting where different objectives may be assessed at the same or different times, each in a group sequential fashion. Pragmatic methods for design and analysis of weighted parametric group sequential design under closed testing procedures are proposed to maintain the strong control of the family‐wise Type I error rate when correlations between tests are incorporated. This results in the ability to relax testing bounds compared to designs not fully adjusting for known correlations, increasing power, or allowing decreased sample size. We illustrate the proposed methods using clinical trial examples and conduct a simulation study to evaluate the operating characteristics.
Exploring sustainable logistics practices toward a circular economy: A value creation perspective
Authors: Jayarathna Chamari Pamoshika , Agdas Duzgun , Dawes Les 
Published: June 2022

AbstractTransforming toward a circular economy (CE) is a viable strategy for achieving sustainable logistics systems. However, it is still unclear how this transformation should be approached because there is limited knowledge in this context. This study aims to explore how the logistics sector incorporates sustainability practices toward CE. To achieve this aim, we addressed the research questions of (RQ1) what sustainability practices are used by the logistics sector and (RQ2) how these practices contribute to transforming the logistics sector into CE. We used a qualitative approach to address these questions by interviewing 14 logistics service providers. Interview transcripts were analyzed by using coding, categorizing, and finding relationships among the concepts identified from the literature following the Gioia method. We identified 47 sustainable logistics practices under nine categories from three key themes: environmental preservation, firm's dynamic capabilities, and social well‐being. We used the natural resource‐based view, dynamic capabilities, and social well‐being theories to identify the key themes. These theories contributed to the existing knowledge on CE strategies from the aspects of environmental, economic, and social value in transforming the logistics sector into CE. We built three propositions based on the findings and the propositions highlight that economic value creation is the core benefit followed by environmental and social value creation in the CE transformation. The identified three themes will provide a holistic approach for implementing CE within the logistics sector.
Effects of greenwashing on financial performance: Moderation through local environmental regulation and media coverage
Authors: Li Wei , Li Weining , Seppänen Veikko , Koivumäki Timo 
Published: June 2022

AbstractRecent research suggests that the effect of greenwashing and corporate financial performance (CFP) is ambiguous. This call for study the contextual factors that create contingencies in the greenwashing–CFP relationship. Using a sample of 2816 observations covering 735 Chinese‐listed firms in 21 different industries from 2013 to 2017, this research examines the effect of greenwashing on CFP and explores the moderating effects of local environmental regulation, media visibility and media favourability. Results show that greenwashing positively affects CFP and effect weakened with stringent environmental regulations and reversed with low media favourability. Our finding implies that stakeholders could hardly identify greenwashing in the context of an emerging economy with high‐level information asymmetry. However, local environmental regulation and negative media coverage could reduce this information asymmetry, making greenwashing easier to be identified. It is the first study to investigate greenwashing–CFP relationship from institutional environment perspective.
Application of informatics in cancer research and clinical practice: Opportunities and challenges
Authors: Hong Na , Sun Gang , Zuo Xiuran , Chen Meng , Liu Li , Wang Jiani , Feng Xiaobin , Shi Wenzhao , Gong Mengchun , Ma Pengcheng 
Published: June 2022

AbstractCancer informatics has significantly progressed in the big data era. We summarize the application of informatics approaches to the cancer domain from both the informatics perspective (e.g., data management and data science) and the clinical perspective (e.g., cancer screening, risk assessment, diagnosis, treatment, and prognosis). We discuss various informatics methods and tools that are widely applied in cancer research and practices, such as cancer databases, data standards, terminologies, high‐throughput omics data mining, machine‐learning algorithms, artificial intelligence imaging, and intelligent radiation. We also address the informatics challenges within the cancer field that pursue better treatment decisions and patient outcomes, and focus on how informatics can provide opportunities for cancer research and practices. Finally, we conclude that the interdisciplinary nature of cancer informatics and collaborations are major drivers for future research and applications in clinical practices. It is hoped that this review is instrumental for cancer researchers and clinicians with its informatics‐specific insights.
Tailoring the NIR‐II Photoluminescence of Single Thiolated Au25 Nanoclusters by Selective Binding to Proteins**
Authors: Bertorelle Franck , Wegner K. David , Perić Bakulić Martina , Fakhouri Hussein , Comby‐Zerbino Clothilde , Sagar Amin , Bernadó Pau , Resch‐Genger Ute , Bonačić‐Koutecký Vlasta , Le Guével Xavier , Antoine Rodolphe 
Published: June 2022

AbstractAtomically precise gold nanoclusters are a fascinating class of nanomaterials that exhibit molecule‐like properties and have outstanding photoluminescence (PL). Their ultrasmall size, molecular chemistry, and biocompatibility make them extremely appealing for selective biomolecule labeling in investigations of biological mechanisms at the cellular and anatomical levels. In this work, we report a simple route to incorporate a preformed Au25 nanocluster into a model bovine serum albumin (BSA) protein. A new approach combining small‐angle X‐ray scattering and molecular modeling provides a clear localization of a single Au25 within the protein to a cysteine residue on the gold nanocluster surface. Attaching Au25 to BSA strikingly modifies the PL properties with enhancement and a redshift in the second near‐infrared (NIR‐II) window. This study paves the way to conrol the design of selective sensitive probes in biomolecules through a ligand‐based strategy to enable the optical detection of biomolecules in a cellular environment by live imaging.
Recent advances in hybridEulerian–Lagrangian description of atomization
Authors: Wang Chao , Jin Tai , Chai Min , Luo Kun , Fan Jianren 
Published: June 2022

AbstractAtomization of liquid fuel is a crucial process to energy utilization. A thorough understanding of the physics of liquid atomization is challenging to acquire but necessary. During the past decades, numerical simulation methods for atomization with interface capturing schemes have been developed rapidly. However, several remaining issues need to be highlighted, such as the minimum size of the droplet to capture, numerical mass defects, and others. Thus, those simulations have been mostly limited to the primary breakup process and cannot capture the huge number of tiny droplets during the secondary breakup process. In recent years, a Eulerian–Lagrangian description of atomization has been introduced for the multi‐scale modelling of its whole process, in which the primary atomization process is treated in the Eulerian framework while the secondary atomization is treated in the Lagrangian framework. This hybrid method has been demonstrated to have many advantages in accuracy and efficiency. Considering its wide applications and contribution to the field, a comprehensive review is made in this work. First, an introduction to the phenomenon of atomization and the development of atomization numerical simulation in recent decades is made. Governing equations in the Eulerian and Lagrangian frameworks are then summarized. This is followed by a discussion of the hybrid combination method, the numerical framework, and its applications in atomization simulations. Last but not least, several relevant issues demanding attention are discussed as well.
Simple Dipyrrin Analogues of Prodigiosin for Use as Colistin Adjuvants
Authors: Siwawannapong Kittipan , Nemeth Ansley M. , Melander Roberta J. , Rong Jie , Davis Jonathan R. , Taniguchi Masahiko , Carpenter Morgan E. , Lindsey Jonathan S. , Melander Christian 
Published: June 2022

AbstractMultidrug resistant (MDR) bacteria are an increasing public health problem. One promising alternative to the development of new antibiotics is the use of antibiotic adjuvants, which would allow the continued use of FDA‐approved antibiotics that have been rendered ineffective due to resistance. Herein, we report a series of dipyrrins and pyrrole derivatives designed as analogues of prodigiosin and obatoclax, several of which potentiate the activity of colistin against Klebsiella pneumoniae, with lead compounds also potentiating colistin against Acinetobacter baumannii and Pseudomonas aeruginosa.
Structural arrangement of auditory brainstem nuclei in the bats Phyllostomus discolor and Carollia perspicillata
Authors: Pätz Christina , Console‐Meyer Laura , Felmy Felix 
Published: June 2022

AbstractThe structure of the mammalian auditory brainstem is evolutionarily highly plastic, and distinct nuclei arrange in a species‐dependent manner. Such anatomical variability is present in the superior olivary complex (SOC) and the nuclei of the lateral lemniscus (LL). Due to the structure–function relationship in the auditory brainstem, the identification of individual nuclei supports the understanding of sound processing. Here, we comparatively describe the nucleus arrangement and the expression of functional markers in the auditory brainstem of the two bat species Phyllostomus discolor and Carollia perspicillata. Using immunofluorescent labeling, we describe the arrangement and identity of the SOC and LL nuclei based on the expression of synaptic markers (vesicular glutamate transporter 1 and glycine transporter 2), calcium‐binding proteins, as well as the voltage‐gated ion channel subunits Kv1.1 and HCN1. The distribution of excitatory and inhibitory synaptic labeling appears similar between both species and matches with that of other mammals. The detection of calcium‐binding proteins indicates species‐dependent differences and deviations from other mammals. Kv1.1 and HCN1 show largely the same expression pattern in both species, which diverges from other mammals, indicating functional adaptations in the cellular physiology of bat neurons.
Global Well‐Posedness of Master Equations for Deterministic Displacement Convex Potential Mean Field Games
Authors: Gangbo Wilfrid , Mészáros Alpár R. 
Published: June 2022

AbstractThis manuscript constructs global in time solutions to master equations for potential mean field games. The study concerns a class of Lagrangians and initial data functions that are displacement convex, and so this property may be in dichotomy with the so‐called Lasry–Lions monotonicity, widely considered in the literature. We construct solutions to both the scalar and vectorial master equations in potential mean field games, when the underlying space is the whole space , and so it is not compact. © 2022 Wiley Periodicals, Inc.
Use of 5,10‐Disubstituted Dibenzoazaborines and Dibenzophosphaborines as Cyclic Supports of Frustrated Lewis Pairs for the Capture of CO2
Authors: Ferrer Maxime , Alkorta Ibon , Elguero Jose , Oliva‐Enrich Josep M. 
Published: June 2022

AbstractThe reactivity of 5,10‐disubstituted dibenzoazaborines and dibenzophosphaborines towards carbon dioxide was studied at the DFT, M06‐2X/def2‐TZVP, computational level. The profile of this reaction comprises of three stationary points: the pre‐reactive complex and adduct minima and the transition state(TS) linking both minima. Initial results show that dibenzoazaborines derivatives are less suitable to form adducts with CO2than dibenzophosphaborine systems. The influence of the basicity on the P atom and the acidity on the B center of the dibenzophosphaborine in the reaction with CO2was also explored. Thus, an equation was developed relating the properties (acidity, basicity and boron hybridization) of the isolated dibenzophosphaborine derivatives with the adduct energy. We found that modulation of the boron acidity allows to obtain more stable adducts than the pre‐reactive complexes and isolated monomers.
Disulfide Isomerization in nDsbD‐DsbC Complex – Exploring an Internal Nucleophile Mediated Reaction Pathway
Authors: Nair Aparna G. , Sravanakumar Perumalla D. , Anjukandi Padmesh 
Published: June 2022

AbstractThe disulfide bond redox chemistry of proteins is believed to be mostly governed by the proton motive force. The nucleophilic and α‐elimination mechanisms are also found to supplement the formation and scission of the S−S bonds. On these grounds, the possibility for an internal nucleophile assisted disulfide bond formation in the nDsbD‐DsbC complex was proposed way back. Using QM/MM MD metadynamics simulations, we explore the feasibility of the proposed mechanism. Our simulations highlight the formation of the internal nucleophile Tyr42O− and Tyr40O− which further generates Cys103S− necessary for the disulfide bond formation in nDsbD. Our results illustrate how the isomerase DsbC is functionally activated by nDsbD in gram‐negative bacteria. Also, we foresee that the results will be important for modelling anti‐bacterial compounds based on nDsbD.