bluuebunny/crossref_metadata_2025_split huggingface dataset:
Questions and health outcomes prioritization for the development of a COVID‐19 dental clinical practice guideline: A case study
Authors: Zaror Carlos , Deana Naira Figueiredo , Espinoza‐Espinoza Gerardo , Aravena‐Rivas Yanela , Muñoz‐Millán Patricia , Pineda Patricia , Burdiles Pamela , Nahuelhual Paula , Canelo‐Aybar Carlos , Alonso‐Coello Pablo 
Published: January 2022

AbstractRationale, Aims and ObjectivesIn the context of a pandemic, the rapid development of clinical practice guidelines (CPGs) is critical. The guideline development process includes prioritization of the guideline topic, questions and health outcomes. This case study describes the application of a new methodology to prioritize questions and rate the importance of health outcomes for a COVID‐19 dental guideline.MethodsPanel members rated the topic and the questions' overall importance, using a 9‐point scale (1 = least important; 9 = most important). In addition, they rated six criteria if multiple questions received the same overall importance rating: common in practice, uncertainty in practice, variation in practice, new evidence available, cost consequences, not previously addressed. Panellists also rated the importance of each outcome, defined with health outcome descriptors, using a 9‐point scale and the utility of health outcomes on a visual analogue scale. The correlation between each criterion and overall question importance was tested by Spearman correlation coefficient.ResultsOf seven topics, four were rated as high priority and three were rated as important, but not of high priority. Thirty‐six percent of the questions (18/50) were rated as high priority to address in the guideline and 64% (32/50) were rated as an important question but not of high priority. Of the 11 outcomes, 72.7% were rated as critical for decision making. The mean utility rating was 0.57 (SD 0.32), with a minimum mean rating of 0.16 and a maximum of 0.76 (SD 0.23).ConclusionThis case study demonstrated that this approach provides a rigorous and transparent methodology to conduct the prioritizations of guideline topics, questions and health outcomes.
Malaysian Society of Gastroenterology and Hepatology consensus statement on metabolic dysfunction‐associated fatty liver disease
Authors: Chan Wah‐Kheong , Tan Soek‐Siam , Chan Siew‐Pheng , Lee Yeong‐Yeh , Tee Hoi‐Poh , Mahadeva Sanjiv , Goh Khean‐Lee , Ramli Anis Safura , Mustapha Feisul , Kosai Nik Ritza , Raja Ali Raja Affendi 
Published: January 2022

AbstractThe Malaysian Society of Gastroenterology and Hepatology saw the need for a consensus statement on metabolic dysfunction‐associated fatty liver disease (MAFLD). The consensus panel consisted of experts in the field of gastroenterology/hepatology, endocrinology, bariatric surgery, family medicine, and public health. A modified Delphi process was used to prepare the consensus statements. The panel recognized the high and increasing prevalence of the disease and the consequent anticipated increase in liver‐related complications and mortality. Cardiovascular disease is the leading cause of mortality in MAFLD patients; therefore, cardiovascular disease risk assessment and management is important. A simple and clear liver assessment and referral pathway was agreed upon, so that patients with more severe MAFLD can be linked to gastroenterology/hepatology care, while patients with less severe MAFLD can remain in primary care or endocrinology, where they are best managed. Lifestyle intervention is the cornerstone in the management of MAFLD. The panel provided a consensus on the use of statin, angiotensin‐converting enzyme inhibitor or angiotensin receptor blocker, sodium–glucose cotransporter‐2 inhibitor, glucagon‐like peptide‐1 agonist, pioglitazone, vitamin E, and metformin, as well as recommendations on bariatric surgery, screening for gastroesophageal varices and hepatocellular carcinoma, and liver transplantation in MAFLD patients. Increasing the awareness and knowledge of the various stakeholders on MAFLD and incorporating MAFLD into existing noncommunicable disease‐related programs and activities are important steps to tackle the disease. These consensus statements will serve as a guide on MAFLD for clinicians and other stakeholders.
Updating the landmark literature for the practice of geriatrics: Notable articles from 2012–2019
Authors: Solberg Laurence M. , Sehgal Mandi , Patel Pragnesh , Akers Katherine G. , Pomputius Ariel , Schwartz Andrea Wershof , Scheiner Shellina R. , Small Alexander , Hidlebaugh Elizabeth , Johnson Theodore M. , Vaughan Camille P. 
Published: January 2022

AbstractBackgroundRemaining current on the latest advances in the peer‐reviewed literature is a basic tenant of medical education and evidence‐based practice. We updated an important prior publication (Vaughan, et al.) identifying landmark articles in geriatric medicine by considering the influence of altmetrics and updating the list with notable articles published between 2012 and 2019.MethodsArticles were identified by searching Web of Science and Scopus for highly cited articles clinically relevant to geriatrics or gerontology and by searching the Altmetric Explorer database for relevant articles with high altmetric scores. The results of the literature search were screened and evaluated using a bibliometric score consisting of an adjusted journal impact factor, citation count, and altmetric score.ResultsThe top 12 notable articles in geriatrics were selected by a consensus panel and ranked using an expert opinion survey. This process reinforces the concept of combining subjective and objective measures to identify notable articles to be used for the education of healthcare professionals in geriatrics principles of care for older adults.ConclusionsWhile our update was performed approximately 9 years after the initial identification of landmark articles, we propose that future updates are conducted at an interval of every 5 years by the governance of a national professional society.
Scutellarin potentiates the skin regenerative function of self growth colony, an optimized platelet‐rich plasma extract, in cultured keratinocytes through VEGF receptor and MAPK signaling
Authors: Guo Maggie Suisui , Gao Xiong , Hu Weihui , Wang Xiaoyang , Dong Tina Tingxia , Tsim Karl Wah Keung 
Published: January 2022

AbstractBackgroundMigration of keratinocyte plays an essential role in wound healing. The proprietary platelet‐rich plasma from human blood, named as self‐growth colony (SGC), functions in stimulating migration of wounded keratinocytes. In addition, the growth factors, including VEGF, being enriched in SGC could account for this function. Scutellarin, an active phytochemical from root of Scutellaria barbata D. Don, has been proposed to have various pharmacological functions; however, the activity in epidermal skin cells is yet to be explored. Here, the role of scutellarin in potentiating the functionality of SGC to promote the regeneration of wounded keratinocyte was probed.MethodsMolecular docking and ultrafiltration‐based LC‐MS were performed to verify the binding between scutellarin and VEGF, which potentiated the VEGF‐mediated functions. Scratch assay, performed on cultured keratinocytes, was to analyze the treatments of SGC and scutellarin in the process of wound healing. Western blot analysis was to confirm the involvement of signaling cascades in observed effects.ResultsWe have identified the binding of scutellarin with VEGF. The binding accounted for the potentiation role of scutellarin in skin regeneration, as triggered by SGC. The co‐treatment of scutellarin and SGC onto scratched keratinocyte cultures was able to enhance the process of wound healing, that is, scutellarin showed a potentiating effect to SGC. In addition, the potentiation of scutellarin was shown to be mediated by phosphorylation of VEGF receptor‐2 (VEGFR2) and mitogen‐activated protein kinase (MAPK) signaling.ConclusionThese findings support the application of scutellarin as an enhancing agent in potentiating the SGC‐mediated wound healing.
Experiences of Online Bullying and Offline Violence‐Related Behaviors Among a Nationally Representative Sample of US Adolescents, 2011 to 2019
Authors: Kreski Noah T. , Chen Qixuan , Olfson Mark , Cerdá Magdalena , Martins Silvia S. , Mauro Pia M. , Branas Charles C. , Rajan Sonali , Keyes Katherine M. 
Published: January 2022

ABSTRACTBACKGROUNDBeing bullied online is associated with being bullied in school. However, links between online bullying and violence‐related experiences are minimally understood. We evaluated potential disparities in these associations to illuminate opportunities to reduce school‐based violence.METHODSWe used five cohorts of Youth Risk Behavior Survey national cross‐sectional data (2011‐2019, Ntotal = 73 074). We used survey‐weighted logistic and multinomial models to examine links between online bullying and five school‐based violence‐related experiences: offline bullying, weapon carrying, avoiding school due to feeling unsafe, being threatened/injured with a weapon, and physical fighting. We examined interactions by sex, race/ethnicity, and sexual identity.RESULTSBeing bullied online was positively associated with all offline violence‐related behaviors. Groups with stronger associations between online bullying and physical fighting, including boys, adolescents whose sexual identity was gay/lesbian or unsure, and many adolescents of color (Black, Hispanic/Latino, and Asian/Pacific Islander adolescents), had stronger associations between online bullying and either weapon carrying or avoiding school.CONCLUSIONSOnline bullying is not an isolated harmful experience; many marginalized adolescents who experience online bullying are more likely to be targeted in school, feel unsafe, get in fights, and carry weapons. Reduction of online bullying should be prioritized as part of a comprehensive school‐based violence prevention strategy.
Efficacy and safety of alfosbuvir plus daclatasvir in Chinese patients with hepatitis C virus genotypes 1, 2, 3, and 6 infection: An open‐label, phase 2 study
Authors: Hua Rui , Kong Fei , Wen Xiaofeng , Xiong Qingfang , Chen Jiayu , Meng Chenxin , Ma Hong , Tan Youwen , Huang Yan , Jiang Yongfang , Guan Yujuan , Mao Xiaorong , Wang Jiefei , Xin Yongning , Gao Hainv , Xu Bin , Li Cheng , Wu Qiong , Zhang Xian , Wang Zhiqiang , Zhao Liwen , Zhang Yuexin , Li Guangming , Niu Junqi 
Published: January 2022

AbstractAlfosbuvir is a novel potent HCV NS5B polymerase inhibitor in development for the treatment of chronic HCV infection. Our previous studies indicated that alfosbuvir monotherapy was well‐tolerated and druggable in healthy subjects and HCV‐infected patients. Here, we evaluate the efficacy and safety of alfosbuvir in combination with daclatasvir in Chinese patients with HCV genotype 1, 2, 3 or 6. In this open‐label study, patients with chronic HCV infection were randomly assigned with a 1:1:1 ratio to receive 12 weeks of daclatasvir 60 mg plus alfosbuvir at a dose of 400, 600 or 800 mg (Cohort A, B or C) daily. Randomization was stratified by HCV genotype and the presence or absence of cirrhosis at screening. The primary endpoint was a sustained virologic response 12 weeks after the end of treatment (SVR12). A total of 124 patients were enrolled in the study, all of whom were available for post‐treatment week 12 assessments. SVR12 was achieved in 92.7% (38/41), 95.2% (40/42) and 100% (41/41) of patients in Cohort A, B and C respectively. The most common adverse events were hepatic steatosis, upper respiratory tract infection, hypercholesterolaemia, hypertriglyceridaemia, blood bilirubin increased, and total bile acids increased. There were no discontinuations due to adverse events, and no treatment‐related serious adverse events were reported. Once‐daily oral administration of alfosbuvir plus daclatasvir were highly effective and safe in Chinese patients infected with HCV genotype 1, 2, 3 or 6, suggesting this regimen could be a promising drug candidate for HCV treatment irrespective of genotype.(ClinicalTrials.gov number, NCT04070235).
Freeflow: The novel portable uroflowmeter can help to realize practical urinary conditions at home
Authors: Kato Shinobu , Watanabe Hajime , Yamasue Kotaro 
Published: January 2022

AbstractObjectivesTo evaluate the effectiveness of a novel portable urine flowmeter, Freeflow, for examining the actual state of urination at home.MethodsForty‐three patients with benign prostatic hyperplasia used the Freeflow uroflowmeter in the hospital and at home without accumulating urine. We created a nomogram for each patient's urine volume and maximal urinary flow rate (Qmax). Furthermore, we investigated the actual state of each patient's urination. We also investigated the differences in the micturition status between daytime and nighttime.ResultsOf the 43 patients, 40 were able to provide the necessary data in the hospital, and all patients provided data measured at home. The trial period of the home assessment was 2‐7 days. Regarding the average urine volume, no significant difference was observed between in‐hospital and at‐home patients; however, Qmax and mean flow rate (Qave) were significantly higher at home. The average coefficient of variation was very large. The relationship between daytime and nighttime was observed in 30 patients; urine volume increased significantly at nighttime; however, no significant difference was observed in Qmax and Qave. The nomogram for several days and a completed urinary diary helped to display daytime and nighttime urination characteristics.ConclusionsFreeflow, the newly developed uroflowmeter, enabled us to determine the fluctuations in the measurements recorded at home and the differences between daytime and nighttime. Thus, creating a nomogram for objectively examining nighttime urination status and utilizing a urination diary was found to be effective for providing correct diagnosis and treatment of lower urinary tract symptoms.
Arthropod moulting hormones (ecdysteroids) are present in the blood of insectivorous bats
Authors: Hornok Sándor , Berkecz Róbert , Sós Endre , Sándor Attila D. , Körmöczi Tímea , Solymosi Norbert , Kontschán Jenő , Hunyadi Attila 
Published: January 2022

AbstractEcdysteroids are steroid hormones involved in moulting and development of arthropods. Blood samples of 32 individual bats of eight insectivorous species were analysed for the presence of ecdysteroids, using liquid chromatography and mass spectrometry. Nine ecdysteroids were detected. The spectrum of these ecdysteroids was similar in bat species which take their preferred food items from the same insect order. The spectrum of blood‐borne ecdysteroids was broader in the autumn than in the summer, and higher concentrations of 20‐hydroxyecdysone (the most common ecdysteroid) occurred in samples from large bat species than from small ones. Ecdysteroids may have anabolic effects on insectivorous bats and may also affect their blood‐feeding arthropod parasites.
Effect of lemon essential oil on halitosis
Authors: Ma Li , Pang Chenyu , Yan Changqing , Chen Jing , Wang Xiaoyu , Hui Jin , Zhou Li , Zhang Xiangyu 
Published: January 2022

AbstractObjectivesTo evaluate the effect of lemon essential oil (LEO) on salivary bacteria and volatile sulfur compound (VSC) production of patients with halitosis.Materials and MethodsSaliva of five patients with halitosis was collected, after adding different concentrations (0.563–9 mg/ml) of LEO, detecting the growth of salivary bacteria, the formation of biofilm, and VSC production, and compare the difference of different concentrations of LEO on bacterial growth and VSC production. 48 volunteers were randomly divided into 4 groups. After gargling with LEO, cetylpyridinium chloride (CPC), chlorhexidine (CHX), and hydrogen peroxide (H2O2) separately measure changes of VSC production and pH values at 30, 45, 60, 90, and 120 min and then compare the differences at different time points within group.ResultsCompared with the negative control group, under subinhibitory concentrations of LEO (0.563–2.25 mg/ml), the biofilm formation and VSC production of salivary bacteria in LEO group were significantly inhibited (p < 0.05). Compared with the baseline, the VSC production of subjects decreased after rinsing with the LEO in 60 min (p < 0.05). After gargling with LEO, the pH value rose significantly in 30 min and reverted to the baseline level at 120 min (p < 0.05).ConclusionsLemon essential oil can inhibit the growth of salivary bacteria and reduce VSC production of patients with halitosis.
Machine learning: A modern approach to pediatric asthma
Authors: Cilluffo Giovanna , Fasola Salvatore , Ferrante Giuliana , Licari Amelia , Marseglia Giuseppe Roberto , Albarelli Andrea , Marseglia Gian Luigi , La Grutta Stefania 
Published: January 2022

AbstractAmong modern methods of statistical and computational analysis, the application of machine learning (ML) to healthcare data has been gaining recognition in helping us understand the heterogeneity of asthma and predicting its progression. In pediatric research, ML approaches may provide rapid advances in uncovering asthma phenotypes with potential translational impact in clinical practice. Also, several accurate models to predict asthma and its progression have been developed using ML. Here, we provide a brief overview of ML approaches recently proposed to characterize pediatric asthma.
Role of air pollutants mediated oxidative stress in respiratory diseases
Authors: Traina Giovanni , Bolzacchini Ezio , Bonini Maira , Contini Daniele , Mantecca Paride , Caimmi Silvia Maria Elena , Licari Amelia 
Published: January 2022

AbstractAirborne particulate (PM) components from fossil fuel combustion can induce oxidative stress initiated by reactive oxygen species (ROS) that are strongly correlated with airway inflammation and asthma. A valid biomarker of airway inflammation is fractionated exhaled nitric oxide (FENO). The oxidative potential of PM2.5 can be evaluated with the dithiothreitol (DTT) dosage, which represents both ROS chemically produced and intracellular ROS of macrophages. This correlates with quality indicators of the internal environment and ventilation strategies such as dilution and removal of airborne contaminants.
Approximate or accurate? Efficacy of daily use of weather and air quality mobile applications for pollen allergy sufferers?
Authors: Travaglini Alessandro , Brighetti Maria Antonia , Della Giustina Auro , Pattini Stefano , Sfika Ifigenia , Malizia Velia , Tripodi Salvatore , Di Menno di Bucchianico Alessandro 
Published: January 2022

AbstractNowadays, technology permeates every aspect of human activity, from the professional to the recreational side, and the recent pandemic crisis has only amplified a clearly defined trend.Through portable devices, people play, work, and get information. The immediacy of information and of many aspects of our life is a condition that, once acquired, is difficult to give up. However, immediate information must also be correct, and not all issues can easily be simplified to the point of being understandable in the absence of basic theoretical notions to a large audience. This aspect is particularly relevant when dealing with issues related to human health and the communication problems encountered in recent months concerning the spread of SARS‐CoV‐2, and the vaccination campaign is there to prove it. With the intent of clarifying the advantages and disadvantages of fast and accessible information, in this article, some of the most widespread applications for mobile devices, dedicated to pollen allergens, air quality, parks, gardens, and green areas, were examined.A widespread lack of clarity on the sources of the data and on the criteria used to formulate synthetic judgments—that often confuse the final users—was noted.
Hypersensitivity reactions to vaccines in children: from measles to SARS‐CoV‐2
Authors: Caffarelli Carlo , Liotti Lucia , Bianchi Annamaria , Bottau Paolo , Caimmi Silvia , Crisafulli Giuseppe , Franceschini Fabrizio , Paglialunga Claudia , Saretta Francesca , Mori Francesca 
Published: January 2022

AbstractAllergic individuals at risk for hypersensitivity reactions to measles vaccine marketed for a long time are well established. On the other hand, risk factors for hypersensitivity reactions to the new mRNA COVID‐19 vaccines currently include a history of allergy, allergy to excipient of the vaccine, or hypersensitivity reactions to the first dose of COVID‐19 vaccine. In the last two cases, the recipient should be assessed by an allergist before vaccination to share a decision on the choice of vaccination. Studies on skin testing accuracy and desensitization protocols to the COVID‐19 vaccines and the efficacy of potential alternatives in patients with confirmed hypersensitivity reactions to the first COVID‐19 vaccine are necessary to improve the safety of COVID‐19 vaccines.
Congenital and acquired defects of immunity: An ever‐evolving story
Authors: Castagnoli Riccardo , Delmonte Ottavia M. , Notarangelo Luigi D. 
Published: January 2022

AbstractInborn errors of immunity (IEI), also referred to as primary immunodeficiencies (PID), are disorders that, for the most part, result from mutations in genes involved in immune host defense and immune regulation. With the increased availability of high‐throughput DNA sequencing and improved genomic data interpretation, the number of newly identified genes associated with IEI has exponentially increased over the last decade. Here, we focus on the newly described IEI associated with severe COVID‐19 and SASH3 deficiency, the most recently reported IEI with impaired T‐cell receptor (TCR) signaling.
Activated phosphoinositide 3‐dinase delta syndrome (APDS): An update
Authors: Lougaris Vassilios , Cancrini Caterina , Rivalta Beatrice , Castagnoli Riccardo , Giardino Giuliana , Volpi Stefano , Leonardi Lucia , La Torre Francesco , Federici Silvia , Corrente Stefania , Cinicola Bianca Laura , Soresina Annarosa , Marseglia Gian Luigi , Cardinale Fabio 
Published: January 2022

AbstractActivated phosphoinositide 3‐kinase delta syndrome (APDS) is a recently described form of inborn error of immunity (IEI) caused by heterozygous mutations in PIK3CD or PIK3R1 genes, respectively, encoding leukocyte‐restricted catalytic p110δ subunit and the ubiquitously expressed regulatory p85 α subunit of the phosphoinositide 3‐kinase δ (PI3Kδ). The first described patients with respiratory infections, hypogammaglobulinemia with normal to elevated IgM serum levels, lymphopenia, and lymphoproliferation. Since the original description, it is becoming evident that the onset of disease may be somewhat variable over time, both in terms of age at presentation and in terms of clinical and immunological complications. In many cases, patients are referred to various specialists such as hematologists, rheumatologists, gastroenterologists, and others, before an immunological evaluation is performed, leading to delay in diagnosis, which negatively affects their prognosis. The significant heterogeneity in the clinical and immunological features affecting APDS patients requires awareness among clinicians since good results with p110δ inhibitors have been reported, certainly ameliorating these patients’ quality of life and prognosis.