bluuebunny/crossref_metadata_2025_split huggingface dataset:
Money Can't Buy You Love: Partisan Responses to Vote‐Buying Offers
Authors: Greene Kenneth F. 
Published: October 2022

AbstractCurrent theory on vote‐buying treats benefits instrumentally as income replacement that always increase utility for the machine. But many recipients react negatively. I argue that responses to selective benefits spring from partisan bias, with opponents motivated to reject a machine that attempts to buy their vote. This new partisan response model helps explain why machines target many supporters, why many opponents remain unpersuaded by selective benefits, and why the electoral return from vote‐buying is often lower than assumed. Tests using conjoint survey experiments in Mexico show that initial supporters are 14.5 percentage points more likely to vote for the machine, whereas initial opponents are 8.5 percentage points less likely to vote for it, holding benefits constant. Mediation analysis reveals that initial supporters demonstrate gratitude for selective benefits and view the machine's actions as legitimate, whereas initial opponents take offense and see machine politics as illegitimate.
Therapeutic potential of brain stimulation techniques in the treatment of mental, psychiatric, and cognitive disorders
Authors: Camacho‐Conde Jose Antonio , del Rosario Gonzalez‐Bermudez Maria , Carretero‐Rey Marta , Khan Zafar U. 
Published: October 2022

AbstractTreatment for brain diseases has been disappointing because available medications have failed to produce clinical response across all the patients. Many patients either do not respond or show partial and inconsistent effect, and even in patients who respond to the medications have high relapse rates. Brain stimulation has been seen as an alternative and effective remedy. As a result, brain stimulation has become one of the most valuable therapeutic tools for combating against brain diseases. In last decade, studies with the application of brain stimulation techniques not only have grown exponentially but also have expanded to wide range of brain disorders. Brain stimulation involves passing electric currents into the cortical and subcortical area brain cells with the use of noninvasive as well as invasive methods to amend brain functions. Over time, technological advancements have evolved into the development of precise devices; however, at present, most used noninvasive techniques are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), whereas the most common invasive technique is deep brain stimulation (DBS). In the current review, we will provide an overview of the potential of noninvasive (rTMS and tDCS) and invasive (DBS) brain stimulation techniques focusing on the treatment of mental, psychiatric, and cognitive disorders.
Constitution and development of the European Union's penal jurisdiction: Responsibility, self‐reference and attribution
Authors: Caeiro Pedro 
Published: October 2022

AbstractThis article looks at how and why the EU has been/can be endowed with powers over criminal matters, within the framework of the theory of jurisdiction. It examines the extent to which the specific responsibility of the EU for the protection of certain legal interests justifies the establishment of a (peripheral) jurisdiction. Member States (MS) can confer such powers upon the EU, but this attribution must be consistent with their domestic obligations and limitations on state action. A crucial distinction is established between exclusive and shared responsibility: the former concerns the protection of ‘institutional legal interests’ exclusive to the EU, whereas the latter relates to ‘functional legal interests’, which also fall within the remit of Member States but are moulded or significantly affected by EU policies. It is argued that this differentiation should translate into the type of acts adopted, which may require some adaptations to traditional guarantees such as the legality principle.
Manganese‐enhanced porous phosphoric acid–based geopolymer templated by carbon for efficient NH3‐SCR of NOx
Authors: Liu Li Cai , Zhang Yao Jun , Chen Hao , He Pan Yang , Li Chan Juan , Meng Qian 
Published: October 2022

AbstractGeopolymer‐based ceramics as catalysts or catalyst supports have attracted tremendous interests in recent years owing to their low‐cost and zeolite‐like structure characteristics. However, most of the reported works focus on alkaline‐based geopolymers, whereas the catalytic performance of acid based geopolymer has not yet been evaluated. This study aims to investigate the application potential of phosphoric acid–based geopolymer (PAG) for selective catalytic reduction (SCR) of NOx with NH3. To this end, the SCR reactivity of PAG and metal oxide (MnOx)‐loaded PAG were evaluated. Moreover, an activated carbon‐based hard template route was proposed for further enhancing the SCR reactivity of the PAG‐based catalyst. The as‐prepared catalyst under the optimal condition exhibited a high NO conversion greater than 85% in a wide temperature range of 250–350°C, which is among the top literature‐reported values, demonstrating its promising application prospect. A systematical X‐ray diffraction, X‐ray photoelectron spectroscopy, field emission scanning electron microscopy, Brunauer–Emmet–Teller, NH3‐temperature‐programed desorption, and H2‐temperature‐programed reduction spectroscopic analyses were also conducted to better understand the structure evolution of PAG under elevated temperature and the SCR catalytic mechanism of the acid‐based geopolymer catalysts. This study would provide valuable information on the potential application prospect of PAG and its modified form for efficient NOx removal.
Effects of SiC on phase transformation and microstructure of spark plasma sintered α/β‐SiAlON composite ceramics
Authors: Yu Kejuan , Yin Zengbin , Guo Fuzhou , Yuan Juntang 
Published: October 2022

Abstractα/β‐SiAlON/SiC composite ceramic tool materials were prepared via spark plasma sintering. The effects of content and size of SiC particles and sintering temperature on phase composition, mechanical properties, and microstructure were investigated. The results indicated that SiC restrained the transformation of β‐SiAlON to α‐SiAlON, but higher SiC content (≥10 wt.%) resulted in a higher Vickers hardness of the composite. The large size of SiC particles raised the densification temperature of α/β‐SiAlON composites, and small SiC particles benefited to improve microstructure. There were more equiaxed α‐SiAlON grains and β‐SiAlON with a larger aspect ratio ( = 5.1) in the α/β‐SiAlON composite containing 100 nm SiC. The sample containing 10 wt.% 100 nm SiC particles sintered at 1700°C had the optimal properties with a Vickers hardness and fracture toughness of 18.5 ± .2 GPa, 6.4 ± .2 MPa m1/2, respectively.
Improvements in skin quality parameters in postmenopausal participants after use of topical growth factor serum
Authors: Gold Michael H. , Wilson April , Makino Elizabeth , Mehta Rahul 
Published: October 2022

AbstractBackgroundPhotodamage can induce skin aging processes that can be particularly concerning for postmenopausal women. Growth factors from hypoxic human fibroblast‐conditioned media have demonstrated improvements in skin quality parameters.AimsThe aim of the study was to assess efficacy and tolerability of topical combination‐treatment hypoxic growth factor serum (TNS A+) in postmenopausal women with moderate to severe facial photodamage.Patients/MethodsIn this 12‐week, open‐label, single‐center study, participants used TNS A+ serum twice daily. Postmenopausal women (40–65 years of age) with Fitzpatrick skin types I–VI and modified Griffiths scale scores 4–9 were eligible. Clinical and participant‐reported assessments were evaluated at Weeks 6 and 12. Statistical significance was defined as p ≤ 0.05.ResultsThere were 17 enrolled participants. TNS A+ treatment demonstrated significant improvements from baseline in fine lines and wrinkles in periocular, forehead, and cheek areas at Week 12 and the perioral area at Weeks 6 and 12. Significant improvements from baseline in coarse lines and wrinkles were observed for the perioral area at Week 12 and periocular and cheek areas at Weeks 6 and 12. Improvements in overall photodamage, skin tone evenness, and tactile roughness were significantly greater at Weeks 6 and 12 versus baseline. Most participants reported TNS A+ made their skin look and feel smooth, soft, and rejuvenated; improved skin radiance; made lines and wrinkles less apparent; and improved skin texture. No treatment‐related adverse events were reported.ConclusionsThe TNS A+ regimen was well tolerated and provided significant improvements in skin quality in postmenopausal women with moderate to severe facial photodamage.
The cross‐modal effect of color and roughness on the perception of spiciness
Authors: Wang Han , Yang Guangyu , Zheng Chundong 
Published: October 2022

AbstractThis study focuses on the cross‐modal correspondence of perception of spiciness produced by the two attributes of color saturation and roughness of hot sauce. There are four experiments in total: Experiment 1 investigated whether red hot sauce generates the strongest expected spiciness after expanding the color selection; Experiment 2 considers the effects of both hot sauce color saturation and roughness attributes on expected spiciness; Experiment 3 explored how different information processing channels affect expected spiciness; and Experiment 4 investigated whether saturation and roughness further affect the actual perceived spiciness and how different information processing channels affect actual spiciness. Results showed that after selecting seven colors, red hot sauce still generates the strongest expected spiciness. Higher saturation of hot sauce color and roughness of the sauce also lead to stronger, expected spiciness. In addition, different processing channels had different effects on saturation and roughness. In expected spiciness, visual processing is an important boundary condition for both attributes, leading to higher expected spiciness. However, in actual perceived spiciness, visual processing is an important boundary condition that leads to higher actual perceived spiciness, though roughness does not have this effect.Practical ApplicationsHot sauce is a common condiment, widely used in food preparation around the world. This study offers important ideas for product and package design of spicy foods, showing how the product itself and its package design can affect consumers' expected and actual perceived spiciness. Manufacturers of spicy food, restaurants, and supermarkets can use these ideas to differentiate saturation, roughness, and package size in product and package design to produce different expected and actual perceived spiciness cross‐modal correspondences to promote sales.
Evaluation of global terrestrial near‐surface wind speed simulated by CMIP6 models and their future projections
Authors: Shen Cheng , Zha Jinlin , Li Zhibo , Azorin‐Molina Cesar , Deng Kaiqiang , Minola Lorenzo , Chen Deliang 
Published: October 2022

AbstractWe evaluate the performance of Coupled Model Intercomparison Project Phase 6 (CMIP6) models in simulating the observed global terrestrial near‐surface wind speed (NSWS) and project its future changes under three different Shared Socioeconomic Pathways (SSPs). Results show that the CESM2 has the best ability in reproducing the observed NSWS trends, although all models examined are generally not doing well. Based on projections of CESM2, the global NSWS will decrease from 2021 to 2100 under all three SSPs. The projected NSWS declines significantly over the north of 20°N, especially across North America, Europe, and the mid‐to‐high latitudes of Asia; meanwhile, it increases over the south of 20°N. Under SSP585, there would be more light‐windy days and fewer strong‐windy days than those under SSP245, which leads to a significant global NSWS decline. Robust hemispheric‐asymmetric changes in the NSWS could be due to the temperature gradient in the two hemispheres under global warming, with −1.2%, −3.5%, and −4.1% in the Northern Hemisphere, and 0.8%, 1.0%, and 1.5% in the Southern Hemisphere, for the near‐term (2021–2040), mid‐term (2041–2060), and long‐term (2081–2100), respectively.
Estimating skills level in recreational skiing: Development and validation of a practical multidimensional instrument
Authors: Luppino Floriana Samantha , den Hollander‐Gijsman Margien Elisabeth , Dekker Friedo Wilhelm , Bartlema Kornelis Alexander , van Diepen Merel 
Published: October 2022

AbstractSkiing and snowboarding are both popular recreational alpine sports, with substantial injury risk of variable severity. Although skills level has repeatedly been associated with injury risk, a validated measure to accurately estimate the actual skills level without objective assessment is missing. This study aimed to develop a practical validated instrument, to better estimate the actual skills level of recreational skiers, based on the criteria of the Dutch Skiing Federation (DSF), and covering five different skill domains. A sample of Dutch recreational skiers (n = 84) was asked to fill in a questionnaire reflecting seven, a priori chosen predictors by expert opinion, to ski downhill and to be objectively evaluated by expert assessors. The instrument was developed to have a multidimensional character and was validated according to the TRIPOD guideline (Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis). The sample reported an overall incorrect self‐reported estimation of their skills, compared with the observed skill score. The instrument showed good calibration and underwent multiple validation methods. The estimated skills score showed to be closer to the observed scores, than self‐reportage. Our study provides a practical, multidimensional, and validated instrument to estimate the actual skills level. It proved to better reflect the actual skills levels compared with self‐reportage among recreational skiers.
Artificial intelligence and the situational rationality of diagnosis: Human problem‐solving and the artifacts of health and medicine
Authors: Raphael Michael W. 
Published: October 2022

AbstractWhat is the problem‐solving capacity of artificial intelligence (AI) for health and medicine? This paper draws out the cognitive sociological context of diagnostic problem‐solving for medical sociology regarding the limits of automation for decision‐based medical tasks. Specifically, it presents a practical way of evaluating the artificiality of symptoms and signs in medical encounters, with an emphasis on the visualization of the problem‐solving process in doctor‐patient relationships. In doing so, the paper details the logical differences underlying diagnostic task performance between man and machine problem‐solving: its principle of rationality, the priorities of its means of adaptation to abstraction, and the effects of seeking optimization in the problem‐solving process. Using these parameters as a heuristic for evaluating the capacity of AI to address issues of diagnostic error through design, the paper presents a conceptual review of the discipline of AI in medicine. Studies relying on procedural rationality describe models that treat diagnosis as a “natural artifact” by employing symbolic methods designed to simulate human problem‐solving. Research adhering to probabilistic rationality describes models that treat diagnosis as a “natural artifact” of an ecological image by utilizing sub‐symbolic methods designed to simulate neural networks. Research guided by situational rationality describes models that require treating diagnosis as a “socio‐cognitive artifact,” the artificiality of which is organized in discourses of patient‐centered decision‐making. The paper concludes with a commentary on the ethical application of AI in health and medicine, given the logical differences underlying diagnostic task performance.
Anti‐CD38 monoclonal antibody interference with blood compatibility testing: Differentiating isatuximab and daratumumab via functional epitope mapping
Authors: Chami Btissam , Okuda Makoto , Moayeri Morvarid , Pirenne France , Hidaka Yoko , Nambiar Ashok , Song Zhili , Bedel Olivier , Zhang Bailin , Hopke Joern , Deng Gejing , Zhu Chen , Macé Sandrine , Chiron Marielle , Adrian Francisco , Fukao Taro , Basile Frank G. , Martin Thomas 
Published: October 2022

AbstractBackgroundThere are two FDA‐approved anti‐CD38 monoclonal antibodies for treatment of multiple myeloma: isatuximab and daratumumab. Owing to expression of CD38 on reagent red blood cells (RBCs), these antibodies interfere with indirect antiglobulin tests (IATs). We sought to understand differences in such interference by performing binding experiments.Study Design and MethodsIn vitro experiments to compare the binding to RBCs of isatuximab and daratumumab alone or in the presence of a mouse anti‐human CD38 antibody (HB‐7 or AT13/5) or a nicotinamide adenine dinucleotide‐analog CD38 inhibitor were performed and quantified by flow cytometry, imaging, mass spectrometry, surface plasmon resonance, and LigandTracer technologies. Serologic testing was performed on plasma samples spiked with isatuximab or daratumumab.ResultsCD38 expressed on RBCs can be directly bound by daratumumab, whereas isatuximab requires a co‐factor, such as HB‐7, AT13/5, or a CD38 inhibitor, suggesting that the isatuximab epitope on RBCs is masked in vitro. Daratumumab samples more frequently showed interference and had stronger reactions than isatuximab samples. Dithiothreitol treatment was equally effective in mitigating the interference caused by either drug.DiscussionBoth isatuximab and daratumumab interfere with IATs but at different magnitudes, reflecting distinct binding to CD38 on RBCs. From the binding studies, we conclude that the isatuximab epitope on RBCs is masked in vitro and binding requires a certain CD38 conformation or co‐factor. This circumstance may explain why interference is seen only in a subset of patients receiving isatuximab when compared with interference seen in most patients on daratumumab therapy.
Validation of laser doppler flowmetry to measure dermal blood flow of the pinnae in dogs with pinnal alopecia
Authors: Ide Kaori , Tokunaga Makoto , Hiratsuka Shogo , Iwasaki Toshiroh , Nishifuji Koji 
Published: October 2022

AbstractBackgroundLaser Doppler flowmetry (LDF) is a noninvasive method of measuring regional blood flow in humans. However, this method has not been widely applied to measure blood flow in dogs.Hypothesis/ObjectivesWe hypothesised that LDF can measure changes in blood flow in canine pinnae accurately. The objectives were to determine whether LDF could accurately detect dermal blood flow changes in canine pinnae caused by haemodynamic drugs and characterize the dermal blood flow in dogs with pinnal alopecia.AnimalsSixteen laboratory‐owned healthy dogs, 25 client‐owned healthy control dogs and six dogs with pinnal alopecia suspected to be secondary to ischaemic dermatoses.Materials and MethodsClinical doses of the haemodynamic drugs atropine, medetomidine and dibutyryl cyclic adenosine monophosphate (dBcAMP), as well as topical dBcAMP, were administered to healthy beagles. Subsequently, an LDF apparatus was attached to the pinnae to analyse changes in dermal blood flow. Finally, LDF was used to measure auricular dermal blood flow in dogs with pinnal alopecia compared to healthy dogs.ResultsDermal blood flow increased after atropine injection, during dBcAMP infusion and after topical dBcAMP ointment application, and decreased after medetomidine injection. Auricular dermal blood flow (in mL/min/100 g tissue) was significantly (p < 0.05) lower in dogs with pinnal alopecia than in healthy dogs.Conclusions and Clinical RelevanceLaser Doppler flowmetry is useful for measuring dermal blood flow in canine pinnae; it can be a noninvasive method to monitor ischaemic conditions of dog skin.
Reperfusion Without Functional Independence in Late Presentation of Stroke With Large Vessel Occlusion
Authors: Seker Fatih , Qureshi Muhammad M. , Möhlenbruch Markus A. , Nogueira Raul G. , Abdalkader Mohamad , Ribo Marc , Caparros Francois , Haussen Diogo C. , Mohammaden Mahmoud H. , Sheth Sunil A. , Ortega-Gutierrez Santiago , Siegler James E. , Zaidi Syed F. , Olive-Gadea Marta , Henon Hilde , Castonguay Alicia C. , Nannoni Stefania , Kaesmacher Johannes , Puri Ajit S. , Farooqui Mudassir , Salazar-Marioni Sergio , Kuhn Anna L. , Kiley Nicole L. , Farzin Behzad , Boisseau William , Masoud Hesham E. , Lopez Carlos Ynigo , Rana Ameena , Abdul Kareem Samer , Sathya Anvitha , Klein Piers , Kassem Mohammad W. , Cordonnier Charlotte , Gralla Jan , Fischer Urs , Michel Patrik , Strambo Davide , Jovin Tudor G. , Raymond Jean , Zaidat Osama O. , Ringleb Peter A. , Nguyen Thanh N. , Nagel Simon 
Published: October 2022

Background:
Reperfusion without functional independence (RFI) is an undesired outcome following thrombectomy in acute ischemic stroke. The primary objective was to evaluate, in patients presenting with proximal anterior circulation occlusion stroke in the extended time window, whether selection with computed tomography (CT) perfusion or magnetic resonance imaging is associated with RFI, mortality, or symptomatic intracranial hemorrhage (sICH) compared with noncontrast CT selected patients.

Methods:
The CLEAR study (CT for Late Endovascular Reperfusion) was a multicenter, retrospective cohort study of stroke patients undergoing thrombectomy in the extended time window. Inclusion criteria for this analysis were baseline National Institutes of Health Stroke Scale score ≥6, internal carotid artery, M1 or M2 segment occlusion, prestroke modified Rankin Scale score of 0 to 2, time-last-seen-well to treatment 6 to 24 hours, and successful reperfusion (modified Thrombolysis in Cerebral Infarction 2c–3).

Results:
Of 2304 patients in the CLEAR study, 715 patients met inclusion criteria. Of these, 364 patients (50.9%) showed RFI (ie, mRS score of 3–6 at 90 days despite successful reperfusion), 37 patients (5.2%) suffered sICH, and 127 patients (17.8%) died within 90 days. Neither imaging selection modality for thrombectomy candidacy (noncontrast CT versus CT perfusion versus magnetic resonance imaging) was associated with RFI, sICH, or mortality. Older age, higher baseline National Institutes of Health Stroke Scale, higher prestroke disability, transfer to a comprehensive stroke center, and a longer interval to puncture were associated with RFI. The presence of M2 occlusion and higher baseline Alberta Stroke Program Early CT Score were inversely associated with RFI. Hypertension was associated with sICH.

Conclusions:
RFI is a frequent phenomenon in the extended time window. Neither magnetic resonance imaging nor CT perfusion selection for mechanical thrombectomy was associated with RFI, sICH, and mortality compared to noncontrast CT selection alone.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04096248.
Hydrocephalus in Context: A History from Graeco-Roman Sources
Authors: Bonati Isabella 
Published: October 2022

Abstract
The history of the scientific description and conceptualisation of the condition named “hydrocephalus” goes back to Graeco-Roman antiquity. The present article provides an extensive examination of the ancient Greek and Latin texts on the topic, including the only extant medical papyrus dealing with it. A thorough investigation of these primary sources allows us to expand our knowledge of this disorder throughout history and how its nosological conception has varied over time.