bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peptidoglycan recognition protein 6 (PGRP6) from Asian corn borer, Ostrinia furnacalis (Guenée) serve as a pattern recognition receptor in innate immune response
Authors: Mei Xianghan , Peng Peilin , Li Chun , Qiao Peitong , He Enxi , Qiu Zhiyong , Xia Dingguo , Zhao Qiaoling , Shen Dongxu 
Published: August 2022

AbstractPeptidoglycan recognition proteins (PGRPs) recognize invading microbes via detecting peptidoglycans from microbial cell walls. PGRPs are highly conserved from insects to vertebrates and all play roles during the immune defensive response. Ten putative PGRPs have been identified through transcriptome analysis in the Asian corn borer, Ostrinia furnacalis (Guenée). Whereas, the biochemical functions of most of them have not yet been elucidated. In this study, we found PGRP6 messenger RNA exhibited extremely high expression levels in the midgut, and its transcript level increased dramatically upon bacterial infection. Moreover, the enzyme‐linked immunosorbent assay indicated recombinant PGRP6 exhibited a strong binding affinity to peptidoglycans from Micrococcus luteus and Bacillus subtilis, which could agglutinate M. luteus and yeast Pichia pastoris. Additionally, we demonstrated that PGRP6 was involved in the pathway of antimicrobial peptides synthesis, but could not enhance encapsulation and melanization of hemocytes. Overall, our results indicated that O. furnacalis PGRP6 serves as a pattern recognition receptor and detects peptidoglycans from microbes to initiate the immune response.
Combination of Two Monoclonal Anti–Citrullinated Protein Antibodies Induced Tenosynovitis, Pain, and Bone Loss in Mice in a Peptidyl Arginine Deiminase‐4–Dependent Manner
Authors: Krishnamurthy Akilan , Circiumaru Alexandra , Sun Jitong , Kisten Yogan , Damberg Peter , Sakuraba Koji , Sandor Katalin , Jarvoll Patrik , Zhou Tunhe , Malmström Vivianne , Svensson Camilla I. , Hensvold Aase , Catrina Anca I. , Klareskog Lars , Réthi Bence 
Published: August 2022

ObjectiveThe appearance of anti–citrullinated protein antibodies (ACPAs) in the circulation represents a major risk factor for developing rheumatoid arthritis (RA). Patient‐derived ACPAs have been shown to induce pain and bone erosion in mice, suggesting an active role in the pathogenicity of RA. We undertook this study to investigate whether ACPAs can induce tenosynovitis, an early sign of RA, in addition to pain and bone loss and whether these symptoms are dependent on peptidyl arginine deiminase 4 (PAD4).MethodsMonoclonal ACPAs generated from plasma cells of RA patients were transferred to wild‐type and PAD4‐deficient mice. Pain‐like behavior and macroscopic inflammation were monitored for a period of 4 weeks, followed by the analyses of tenosynovitis in the ankle joints using magnetic resonance imaging (MRI) and bone microarchitecture in the tibia using an X‐ray microscope. Microscopic changes in the tendon sheath were analyzed in decalcified ankle joint sections.ResultsThe combination of 2 monoclonal ACPAs (1325:04C03 and 1325:01B09) induced long‐lasting pain‐like behavior and trabecular bone loss in mice. Although no synovitis was observed macroscopically, we detected tenosynovitis in the ACPA‐injected mice by MRI. Microscopic analyses of the joints revealed a cellular hyperplasia and a consequent enlargement of the tendon sheath in the ACPA‐treated group. In PAD4−/− mice, the effects of ACPAs on pain‐like behavior, tenosynovitis, and bone loss were significantly reduced.ConclusionMonoclonal ACPAs can induce tenosynovitis in addition to pain and bone loss via mechanisms dependent on PAD4‐mediated citrullination.image
A multi‐stakeholder engagement framework for knowledge management in ICT4D
Authors: Thomas Manoj A. , Li Yan , Sistenich Vera , Diango Ken Ngoy , Kabongo Diulu 
Published: August 2022

AbstractKnowledge management (KM) is increasingly important to the field of information and communication technologies for development (ICT4D). Yet, scant literature has addressed KM in the ICT4D context. This study takes an important step toward addressing this gap by conceptualizing KM in the context of ICT4D based on the people‐process‐technology perspective. To elicit KM factors most relevant to ICT4D, a Delphi study is conducted with a panel of experts representing three key stakeholder groups (beneficiaries, partners, and designers) with cumulative experience of leading ICT4D projects in 25 countries. Based on the Delphi study findings, 16 factors relevant to KM in ICT4D are synthesized. A multi‐stakeholder engagement framework for KM in ICT4D and an activity checklist are proposed. The study contributes to the body of knowledge by providing insights into the differing views of stakeholders related to KM practices in ICT4D projects. Practitioners may find the framework and checklist useful in coordinating and managing KM in ICT4D projects. As development initiatives become increasingly knowledge focused, the study calls upon researchers for more enquiry in this progressive area of study.
The effectiveness of flagging content belonging to prominent individuals: The case of Donald Trump on Twitter
Authors: Chipidza Wallace , Yan Jie (Kevin) 
Published: August 2022

AbstractThere is vigorous debate as to whether influential social media platforms like Twitter and Facebook should censor objectionable posts by prominent individuals in the United States and elsewhere. A tentative middle ground is employing content moderation to signal to social media audiences that certain posts may contain objectionable information through the mechanism of flagging. Existing studies have mainly examined the effect of flagging regular users' content. To add to this emerging literature stream, we examine the effect of flagging when the underlying content is produced by a prominent individual. Leveraging Twitter's moderation activities on former U.S. President Donald Trump's tweets as our empirical setting, we employ three machine learning algorithms to estimate the effect of flagging Trump's tweets. We explore preliminary evidence as to whether these posts were retweeted less or more than expected. Our results indicate that the flagged tweets were retweeted at higher rates than expected. Our findings suggest that flagging content of prominent individuals on social media might be ineffective or even counterproductive in curbing the spread of content deemed objectionable by social media companies.
The Labile Nature of Air Stable Ni(II)/Ni(0)‐phosphine/Olefin Catalysts/Intermediates: EDA‐NOCV Analysis
Authors: Gorantla Sai Manoj N. V. T. , Mondal Kartik Chandra 
Published: August 2022

AbstractMetal ions‐based inorganic‐organic hybrid composites are often reported acting as good to excellent catalysts with various substrate scopes under milder reaction conditions. The active catalyst of a catalytic cycle is sometimes proposed to be a short‐lived reactive intermediate species. A three coordinate (L−Me)Ni(II) intermediate species [L−Me=O2N donor dianionic ligand] can bind with short‐lived carbene‐ester ligands to produce four coordinate Ni(II) species which can act as carbene transfer intermediate under suitable reaction conditions for C−H functionalization and/or cyclopropanation reactions. The dissociation of phosphine (PPh3) from the Ni(II) centre of (L−Me)Ni(II)(PPh3) (1 a) and binding of short lived carbene esters (:CR1−CO2R2; R1=H, Ph; R2=aliphatic group; 2–4 and other carbenes; 5–10) to Ni(II) rationalize the phenomenon in solution. Air stable Ni(0)‐olefin complexes/intermediates (12–18) have recently been shown to mediate a variety of organic transformations. This analysis will further help organic/organometallic chemists to rationalize the design and synthesis of future catalysts for organic transformation. EDA‐NOCV calculations have been performed to shed light on the stability and bonding of those species. Additionally, our analysis provides a proper reason why the analogous (L−Me)Pd−PPh3 complex (1 b) does not dissociate in solution and hence, a similar catalytic product has not been isolated from identical reaction conditions. The stability and the labile nature of Ni(II/0) complexes have been investigated by state‐of‐the‐art EDA‐NOCV analyses.
Application of Nanopore Sensors for Biomolecular Interactions and Drug Discovery
Authors: Jeong Ki‐Baek , Kim Jin‐Sik , Dhanasekar Naresh Niranjan , Lee Mi‐Kyung , Chi Seung‐Wook 
Published: August 2022

AbstractBiomolecular interactions, such as protein‐protein, protein‐nucleic acid, and protein/nucleic acid‐ligand interactions, play crucial roles in various cellular signaling and biological processes, and offer attractive therapeutic targets in numerous human diseases. Currently, drug discovery is limited by the low efficiency and high cost of conventional ensemble‐averaging‐based techniques for biomolecular interaction analysis and high‐throughput drug screening. Nanopores are an emerging technology for single‐molecule sensing of biomolecules. Owing to the notable merits of single‐molecule sensing, nanopore sensors have contributed tremendously to nucleic acid sequencing and disease diagnostics. In this minireview, we summarize the recent developments and outlooks in single‐molecule sensing of various biomolecular interactions for drug discovery applications using biological and solid‐state nanopore sensors.
First trimester COVID‐19 and the risk of major congenital malformations–International Registry of Coronavirus Exposure in Pregnancy
Authors: Hernández‐Díaz Sonia , Smith Louisa H. , Wyszynski Diego F. , Rasmussen Sonja A. 
Published: August 2022

AbstractThere is limited information about the effects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection during the first trimester of pregnancy on the risk of major congenital malformations (MCMs). The International Registry of Coronavirus Exposure in Pregnancy (IRCEP) was designed to estimate the relative risk of adverse perinatal outcomes among women with Coronavirus Disease 2019 (COVID‐19) at specific times during gestation. Adult women were eligible to enroll if they had a SARS‐CoV‐2 test, regardless of the results, or clinically confirmed COVID‐19 during pregnancy. Self‐administered questionnaires collected data on SARS‐CoV‐2 infection, pregnancy outcomes (including detailed questions on MCMs), and potential confounders. The analysis of MCMs includes women with either a positive SARS‐CoV‐2 PCR test or a clinical diagnosis of COVID‐19 during the first trimester (exposed group) or a negative SARS‐CoV‐2 test (reference) that enrolled while pregnant. Sensitivity analyses were restricted to participants who enrolled before the availability of informative prenatal screening tests and extended to those enrolled after end of pregnancy. Generalized linear models were used to estimate relative risks (RR) and 95% confidence intervals (CI). Of 17,163 participants enrolled between June 2020 and July 2021, 1727 had a SARS‐CoV‐2 infection during the first trimester, of whom 1,675 enrolled during pregnancy. Of 10,235 controls with a negative test during pregnancy, 4,172 enrolled during pregnancy. Restriction to participants with complete follow‐up reduced the sample size to 92 exposed and 292 unexposed reference pregnancies. MCMs were reported in 3 (3.3%) exposed and 8 (2.7%) unexposed (RR 1.2; 95% CI 0.32–4.2) newborns. The RR was 2.5 (95%CI 0.23–27) among those enrolled before prenatal screening, and 2.2 (95%CI 0.89–5.3) in the overall study population including those enrolled post‐pregnancy. No specific pattern of malformations was observed. Although results are compatible with no major teratogenic effects associated with maternal SARS‐CoV‐2 infection, RR estimates were imprecise and larger studies are warranted.
Is extremely low frequency pulsed electromagnetic fields applicable to gliomas? A literature review of the underlying mechanisms and application of extremely low frequency pulsed electromagnetic fields
Authors: Huang Mengqian , Li Parker , Chen Feng , Cai Zehao , Yang Shoubo , Zheng Xiaohong , Li Wenbin 
Published: August 2022

AbstractGliomas refer to a group of complicated human brain tumors with a low 5‐year survival rate and limited therapeutic options. Extremely low‐frequency pulsed electromagnetic field (ELF‐PEMF) is a specific magnetic field featuring almost no side effects. However, the application of ELF‐PEMF in the treatment of gliomas is rare. This review summarizes five significant underlying mechanisms including calcium ions, autophagy, apoptosis, angiogenesis, and reactive oxygen species, and applications of ELF‐PEMF in glioma treatment from a clinical practice perspective. In addition, the prospects of ELF‐PEMF in combination with conventional therapy for the treatment of gliomas are reviewed. This review benefits any specialists, especially oncologists, interested in this new therapy because it can help treat patients with gliomas properly.
Vestibular tunnel approach in restoring non‐carious cervical lesion gingival recessions with combination of bioceramics and collagen matrix: A case report with a 1‐year follow‐up
Authors: Chang Kai‐Chiao Joe , Mumford John H. , Long Alex , Ton Vinh H. 
Published: August 2022

AbstractIntroductionNon‐carious cervical lesions (NCCLs) can compromise the integrity to both hard and soft tissues of teeth. This case report introduces a novel interdisciplinary technique by utilizing bioceramics‐based cement (BBC) and porcine collagen matrix (CM) to reconstruct the dentogingival complex where enamel, dentin, and soft tissues were involved.Case presentationA 38‐year‐old healthy male was referred to the periodontics department for gingival recessions teeth #27–29 and a deep (NCCL) on the facial (F) #28 involving the loss of the cementoenamel junction (CEJ). The F #28 was restored with BBC according to manufacturing instructions. Soft tissues of #27–29 were simultaneously augmented with two CM strips via a coronally advanced tunnel utilizing suspended sutures. At the 6‐month follow‐up, approximately 100% root coverages were obtained for #27 and 29. The F #28 gingival tissue stabilized at the anticipated level of maximum root coverage (MRC), 1 mm apical to the coronally displaced CEJ. The exposed layer of BBC, F #28, was veneered with resin‐modified glass ionomer to re‐establish the original position of the CEJ. At the one‐year follow‐up visit root coverage for #28 remained stable and probing depths remained unchanged at 2 mm F #27–29. A sectional cone beam computed tomography scan illustrated the BBC restoration remained intact and well adapted.ConclusionThe 12‐month follow‐up illustrated that the BBC may be a viable restorable material while performing simultaneous gingival grafting with CM in deep NCCLs with gingival recessions.Key pointsWhy is this case new information?

A novel approach treating the deep non‐carious cervical lesion with BBC and CM.What are the keys to successful management of this case?

The BBC placement needs to be flat.
Secure the surgical site with non‐resorbable suspensory sutures fixed by flowable composite.
What are the primary limitations to success in this case?

The primary limitation to success is the blood moisture control which may limit the placement of collagen matrix strips via the portal entry.
Do not put the blame on me: Asymmetric responses to service outcome with autonomous vehicles versus human agents
Authors: Pozharliev Rumen , De Angelis Matteo , Donato Carmela , Rossi Dario 
Published: August 2022

AbstractThe present study aims to examine customer responses to negative (vs. positive) service outcome with an autonomous vehicle (AV) vis‐à‐vis human agent. In the first study we manipulate the outcome of the service (negative vs. positive) and the type of service agent (AV vs. human) to evaluate customers' satisfaction with the service. Based on the results of the first study, in the second study we focus only on the negative outcome scenario and we examine how the perceived blame of the AV (vs. human agent) affects customers' satisfaction. Finally, in the third study we introduce another mediator, namely perceived competence, which explains why people attribute less blame to the AV (vs. human agent). Customers' satisfaction is higher for the AV only in the case of a negative service outcome, while no differences emerge when the service had a positive outcome. Additionally, AVs (vs. human agent) are perceived as less competent and blameworthy, leading to a higher customer satisfaction with the service in case of a negative outcome. These results show a customer under‐reaction to negative service outcome with AVs. This has relevance for the design and policy implications related to AVs. Our results also provide insights into the psychological underpinnings of acceptance of AVs replacing human agents. This study extends previous literature by showing circumstances in which customers are more (or less) satisfied with an AVs (vs. human agents) and the psychological drivers of these asymmetrical responses.
Six New Polyoxygenated Xanthones from Garcinia cowa and Their Neuroprotective Effects on Glutamate‐Mediated Hippocampal Neuronal HT22 Cell Death
Authors: Nguyen Thi Kim An , Nguyen Bao Ngoc , Hoang Thi Minh Nguyet , Doan Lan Phuong , Phan Minh Giang , Lee Heesu , Kim Dae Won , Lee Jae Wook , Tran Thi Thu Thuy 
Published: August 2022

AbstractSix new polyoxygenated xanthones, garcicowanones F–H (1‐3), norcowanol A–B (4‐5), and garcinone F (6) along with twelve known compounds 7–18 were obtained from the latex of Garcinia cowa Roxb. ex Choisy. All new compounds have a 1,3,7‐trioxygenated or 1,3,6,7‐tetraoxygenated xanthone nucleus and differ from majority of xanthones from G. cowa by hydrated side chains. Compounds 1, 7, 8 and 18 exhibited significant neuroprotective effects on glutamate‐mediated hippocampal neuronal HT22 cell death. In particular, compound 1 exhibited the most potent neuroprotective effect with >80 % cell viability in the concentration range of 2.9–115 μM. Further studies on compound 1 showed that it decreased cellular Ca2+ influx and inhibits cellular reactive oxygen species generation in HT22 cells. A Western blot analysis showed that MAPK phosphorylation, Bax, and AIF translocation dramatically increased upon treatment with 5 mM glutamate and decreased upon a co‐treatment with compound 1.
Cystic fibrosis and jejunoileal atresia: A clinical case
Authors: Cunha Sara Bernardes da , Rasteiro Cátia , Silva Manuela , Dias Mariana , Araújo Célia , Ramalho Carla 
Published: August 2022

AbstractWe present a case report of a fetal diagnosis of cystic fibrosis after ultrasound abnormalities. After delivery, a type 3A intestinal atresia was diagnosed. Segmental enterectomy with end‐to‐end anastomosis was performed. This case report highlights the diagnosis complexity of a fetal intestinal atresia associated with cystic fibrosis.
Posttraumatic ascending myelopathy after spinal cord injury in a young man: A case report
Authors: Esmaeilnia Mostafa , Asadi Mona , Sharara Hussein 
Published: August 2022

AbstractA 29‐year‐old man developed subacute posttraumatic ascending myelopathy 5 days after a spinal cord injury. He developed a fever and a blood culture showed an Alkaligenes spp. infection. Despite antibiotic and high‐dose corticosteroid therapy, same neurological deficits persisted, and a follow‐up MRI showed atrophy and swelling in the cervical cord.
Isolated leukemia cutis as extramedullary relapse of acute myeloid leukemia
Authors: Dadrass Farinoosh , Esmail Fatema , Regmi Aayushma , Mudaliar Kumaran , Mirza Kamran M. , Kini Ameet R. , Kim Wendy , Hagen Patrick , Hossain Nasheed M. 
Published: August 2022

AbstractAcute myeloid leukemia (AML) arises from clonal expansion of malignant hematopoietic precursor cells in the bone marrow. In rare instances, AML can recur with prominent extramedullary manifestations (i.e., leukemia cutis or myeloid sarcoma), either simultaneously or preceding marrow involvement, or as a sole site of primary disease relapse.
Invasive ductal carcinoma of breast with neuroendocrine differentiation: A case report
Authors: Aryal Vinayak , Singh Moushami , Neupane Karun , Marhatta Adwait , Amatya Kapendra S. , Dhakal Hari P. 
Published: August 2022

AbstractPrimary invasive breast carcinoma with neuroendocrine differentiation is an uncommon presentation. We hereby report a case diagnosed as invasive ductal carcinoma with neuroendocrine differentiation in a 52‐year‐old female patient who presented with a painless right breast lump.
Ophthalmia neonatorum due to Escherichia coli: A rare cause or an emerging bacterial etiology of neonatal conjunctivitis?
Authors: Saadeh‐Jackson Stephanie , Rodriguez Linnet , Leffler Christopher T. , Freymiller Casey , Wolf Elizabeth , Wijesooriya Niran , Couser Natario L. 
Published: August 2022

AbstractSince the introduction of universal gonococcal and chlamydia prophylaxis, other etiologies for neonatal conjunctivitis such as Escherichia coli have become more common. Early eye culturing as part of the management plan could provide swifter treatment and preservation of vision potential in affected neonates.
Surgical correction of third eyelid cartilage eversion in an Anglo‐Nubian goat: A case report
Authors: Donohue Laura K. , Mack Zoe E. , Ledbetter Eric C. 
Published: August 2022

AbstractThis case of everted third eyelid cartilage in a goat demonstrates that everted cartilage occurs in animals other than domestic dogs and cats. Everted cartilage in the goat can be treated successfully with surgical excision of the abnormally bent cartilage.
Effect of electrolyte solubility and column inclination on the performance of monoethylene glycol regeneration process
Authors: Kim Hyunho , Jung Jong Yeon , Park Ki‐Heum , Seo Yutaek 
Published: August 2022

AbstractIn this study, the solubilities of potassium‐chloride (KCl) in aqueous monoethylene glycol (MEG) solution and the vapour pressure of aqueous MEG solution containing KCl were investigated. A thermodynamic model was modified based on the data obtained to predict the solubilities of KCl, which was then applied to optimize the MEG regeneration process that is widely used in offshore gas fields. The solubility of KCl in the aqueous MEG solution decreased with an increase in MEG concentration and a decrease in temperature. The presence of KCl in aqueous MEG solution decreased the vapour pressure, thus increasing the boiling temperature at the corresponding pressure. A thermodynamic model based on the electrolyte non‐random two‐liquid (NRTL) coupled with the Redlich–Kwong (RK) equation of state was employed by modifying the binary interaction parameters using the experimental data. The modified model predicted the solubilities of KCl and the vapour pressure of aqueous MEG solutions, which were in good agreement with the experimental data. Moreover, the distillation column in pilot‐scale MEG regeneration was inclined to simulate the movement of the offshore platform, showing decreasing MEG concentration, possibly due to the distribution issues inside the column.
Isolation of a Natural Killer Group 2D Small‐Molecule Ligand from DNA‐Encoded Chemical Libraries
Authors: Dakhel Sheila , Galbiati Andrea , Migliorini Francesca , Comacchio Claudia , Oehler Sebastian , Prati Luca , Scheuermann Jörg , Cazzamalli Samuele , Neri Dario , Bassi Gabriele , Favalli Nicholas 
Published: August 2022

AbstractNatural Killer Group 2D (NKG2D) is a homo‐dimeric transmembrane protein which is typically expressed on the surface of natural killer (NK) cells, natural killer T (NKT) cells, gamma delta T (γδT) cells, activated CD8 positive T‐cells and activated macrophages. Bispecific molecules, capable of bridging NKG2D with a target protein expressed on the surface of tumor cells, may be used to redirect the cytotoxic activity of NK‐cells towards antigen‐positive malignant T‐cells. In this work, we report the discovery of a novel NKG2D small molecule binder [KD=(410±60) nM], isolated from a DNA‐Encoded Chemical Library (DEL). The discovery of small organic NKG2D ligands may facilitate the generation of fully synthetic bispecific adaptors, which may serve as an alternative to bispecific antibody products and which may benefit from better tumor targeting properties.