bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concepts for creating augmented reality based technical documentations for the maintenance of machine tools
Authors: Klimant Philipp , Kollatsch Christian 
Published: April 2022

AbstractThe maintenance process of machine tools becomes more complex and difficult due to its increasing complexity and individuality. Augmented reality (AR) can support the maintenance engineer by visualizing the process with individual working steps and further information in a user-friendly manner. In order to an efficient deployment, a short and automated creation process of the AR based documentation is required including the integration of existing systems and data such as the technical documentation, CAD models and PDM data. This avoids a complete rewriting and manual creation of the AR based documentation in addition to the standard paper-based version. Therefore, various concepts for creating AR based technical documentations for the maintenance of machine tools are presented and verified including an analysis of the required documentation data, systems and processes.
The effect of perceived discrimination on cross-cultural adaptation of international students: moderating roles of autonomous orientation and integration strategy
Authors: Yang Fan , He Yuxuan , Xia Zhichen 
Published: April 2022

AbstractThis study explores the associations between perceived discrimination and cross-cultural adaptation among 335 international students in China. Drawing on self-determination theory, we propose that autonomous orientation can weaken the relationship between perceived discrimination and cross-cultural adaptation. Integration strategy can be seen as a mechanism that encourages international students to embrace both their original and host culture when they feel be discriminated. Results indicate that perceived discrimination is negatively associated with sociocultural adaptation and psychological adaptation among international students in China. Our research identifies autonomous orientation as an important contingency that weakens the effects of perceived discrimination on cross-cultural adaptation, confirming the moderating role of integration strategy in the relationship between perceived discrimination and sociocultural adaptation. Integration strategy mediates the moderating effects of autonomous orientation on the relationship between perceived discrimination and sociocultural adaption. The findings provide valuable insight into the positive impact of autonomous orientation and integration strategy on the cross-cultural adaptation of international students when they feel be discriminated, which is beneficial to the education and management of international students at the theoretical and practical levels.
Investigation on Thermal Behavior During Pressurization Discharge of Liquid Oxygen Under Different Acceleration Levels
Authors: Liu Zhan , Yin Xin , Liu Yuanliang , Li Yanzhong 
Published: April 2022

AbstractCryogenic pressurization discharge involves on complex heat exchange and fluid flow issues, and the related thermal physical performance should be comprehensively investigated. In this study, a two-dimensional axisymmetric numerical model is adopted to research the outflow characteristic from a cylindrical liquid oxygen storage tank with the gas injection. The VOF method is utilized to predict the pressurization discharge with 360 K high-temperature gaseous oxygen as the pressurant gas. Validated against the liquid hydrogen discharge experiments, the numerical model is turned out to be proper and acceptable with the calculation errors limited within 20%. On the basis of the numerical model, effect of the flight acceleration level on the tank pressurization and liquid outflow performance are numerically simulated and analyzed, with the gas injection rate of 0.18 kg/s and the liquid outflow rate of 36.0 kg/s. Some valuable conclusions are obtained finally. The present study is significant to the safety flight of launch vehicle and may supply some technical supports for the design of cryogenic propellant system.
Evaluating value mediation in patients with chronic low-back pain using virtual reality: contributions for empirical research in Value Sensitive Design
Authors: Smits Merlijn , van Goor Harry , Kallewaard Jan-Willem , Verbeek Peter-Paul , Ludden Geke D.S. 
Published: April 2022

AbstractValue Sensitive Design (VSD) is the most well-known method to consider values in design. It consists of three iterative phases of investigation: conceptual, empirical, and technical. Although the approach is promising, the role of empirical research remains unclear. We address two opportunities for extending the role of empirical research in VSD. First, we argue that empirical research enables us to identify values in context. Second, we explain that empirical research enables us to anticipate how technology mediates the values of users. We make our point by means of an empirical study in a real-life controlled experimental context into the value mediation of virtual reality (VR) in patients with chronic low-back pain. Using value-oriented semi-structured interviews with twenty patients, we first analyze what values these patients consider important, and how the values are experienced. The second set of interviews held after all patients used VR four weeks at home, aims to provide insight into value changes as mediated by VR. We end the article by a comparison of our empirical results with previous, often speculative, literature into values in VR. We show that empirical research benefits the VSD process by providing in-depth insight into the effects of context and technology on values and the ability to translate these insights into recommendations for more responsible design and implementation of the technology.
Children and adolescents do not compensate for physical activity but do compensate for sedentary behavior
Authors: Nigg Carina , Burchartz Alexander , Reichert Markus , Woll Alexander , Niessner Claudia 
Published: April 2022

AbstractLittle is known about behavioral transfer and compensation within and between moderate-to-vigorous physical activity (MVPA) and sedentary behavior. Thus, taking a within-person perspective, this study investigated across 1 week whether (a) children and adolescents compensate for increased MVPA and sedentary behavior with less of the respective behavior the next day and (b) transfer and compensation occur between these behaviors within 1 day and across 2 days. We obtained data from 2676 participants (6–17 years) of the national Motorik-Modul (MoMo) study in Germany. Participants wore an ActiGraph accelerometer (Pensacola, FL, USA) for 7 days. We analyzed within- and between-day associations using hierarchical linear modeling. If youth engaged in 2 h more sedentary behavior than typical on any given day, they engaged in 37.20 min less MVPA the same day (B = −0.31, p < 0.001) as well as in 4.80 min more MVPA (B = 0.04, p < 0.001) and 7.20 min less sedentary behavior (B = −0.06, p < 0.001) the next day. If youth engaged in 1 h more MVPA than typical on any given day, they engaged in 97.80 min less sedentary behavior the same day (B = −1.63, p < 0.001) and in 5.40 min less sedentary behavior the next day (B = −0.09, p < 0.001). No association with next-day MVPA was observed. Our results indicate that children do not compensate for enhanced MVPA but transfer to less sedentary behavior, while more sedentary behavior is compensated with less sedentary behavior and more MVPA the next day. This provides essential information for the design of intervention studies to tackle physical inactivity and sedentary behavior.
Ecosystem-based governance according to the Malawi principles: a test for the southern Lake Malawi
Authors: Msomphora Mbachi Ruth , Njaya Friday , Jentoft Svein 
Published: April 2022

AbstractThis paper examines what may happen when the internationally renowned Malawi principles for ecosystem-based fisheries management are implemented in real-life situations. To explore this, an ecosystem-based fisheries management plan for the southern part of the Lake Malawi is used as a case study. However, the lessons learned are relevant for the global implementation of these principles. Drawing on ‘interactive governance theory’, we argue that implementation involves all three ‘governance-orders’, (1) where the governance principles are formulated, (2) where the institutions are designed to operationalise and implement these principles, and (3) where implementation and enforcement actually take place and become routine operation. The Malawi principles must be institutionalised and, subsequently, find their concretisation in the way the southern Lake Malawi ecosystem is actually managed by, and according to, the Malawi Principles and the institutions of which management is a function. Our case study portrays the need to build capacity to address the implementation challenges as they appear at all three governance-orders. We suggest that ecosystem-based governance is a more appropriate term, for what the Malawi principles aim to achieve, than management, which we associate with the more technical elements of this approach.
The Placental Epigenome as a Molecular Link Between Prenatal Exposures and Fetal Health Outcomes Through the DOHaD Hypothesis
Authors: Lapehn Samantha , Paquette Alison G. 
Published: April 2022

Abstract
Purpose of Review
The developmental origins of health and disease (DOHaD) hypothesis posits that the perinatal environment can impact fetal and later life health. The placenta is uniquely situated to assess prenatal exposures in the context of DOHaD because it is an essential ephemeral fetal organ that manages the transport of oxygen, nutrients, waste, and endocrine signals between the mother and fetus. The purpose of this review is to summarize recent studies that evaluated the DOHaD hypothesis in human placentas using epigenomics, including DNA methylation and transcriptomic studies of mRNA, lncRNA, and microRNAs.

Recent Findings
Between 2016 and 2021, 28 articles evaluated associations between prenatal exposures and placental epigenomics across broad exposure categories including maternal smoking, psychosocial stressors, chemicals, air pollution, and metals. Sixteen of these studies connected exposures to health outcome such as birth weight, fetal growth, or infant neurobehavior through mediation analysis, identification of shared associations between exposure and outcome, or network analysis. These aspects of infant and childhood health serve as a foundation for future studies that aim to use placental epigenetics to understand relationships between the prenatal environment and perinatal complications (such as preterm birth or fetal growth restriction) or later life childhood health.

Summary
Placental DNA methylation and RNA expression have been linked to numerous prenatal exposures, such as PM2.5 air pollution, metals, and maternal smoking, as well as infant and childhood health outcomes, including fetal growth and birth weight. Placental epigenomics provides a unique opportunity to expand the DOHaD premise, particularly if research applies novel methodologies such as multi-omics analysis, sequencing of non-coding RNAs, mixtures analysis, and assessment of health outcomes beyond early childhood.
Indikationen und Kontraindikationen zur Lebertransplantation in Bezug auf aktuelle Leitlinien
Authors: Berlakovich Gabriela 
Published: April 2022

ZusammenfassungDie Grundlage für die Beurteilung der Schwere der Lebererkrankung ist der Model-of-End-Stage-Liver-Disease(MELD)-Score. Eine Indikation zur Listung für eine Lebertransplantation ist bei einem MELD-Score ≥ 15 gegeben oder bei einem MELD-Score < 15 bei inakzeptabler Lebensqualität aufgrund der Lebererkrankung oder Sekundärkomplikationen der Zirrhose. Es sollte aber nicht nur die Indikation, sondern auch die Kontraindikation zur Lebertransplantation überlegt werden, um eine aussichtslose Transplantation, definiert als 6‑Monats-Überleben < 60 % oder 5‑Jahres-Überleben < 50 %, möglichst zu vermeiden. Die alkoholische Zirrhose stellt weltweit eine der 3 Hauptindikationen zur Lebertransplantation dar und die Ergebnisse sind mit denen anderer Ätiologien vergleichbar. Mit Entwicklung von effektiven Medikamenten zur Behandlung der Hepatitis C war eine deutliche Reduktion der Lebertransplantationen in dieser Indikation zu beobachten. Zeitgleich mit der Reduktion der Transplantationen bei Hepatitis C ist ein Anstieg der nichtalkoholischen Steatohepatitis (NASH) zu verzeichnen. Im Kontext mit dem metabolischen Syndrom ist vor allem das kardiovaskuläre Risiko erhöht und bei schwerwiegenden Komorbiditäten wird eine rigorose Patient*innenselektion empfohlen. Für Malignome werden unter Beschränkung auf das hepatozelluläre Karzinom (HCC) und Einhaltung von Selektionskriterien, teilweise mit Berücksichtigung biologischer Surrogatmarker, vergleichbare Ergebnisse zu anderen Indikationen erzielt. Bei Diagnose eines akuten oder subakuten Leberversagen ist bei klinischer Verschlechterung mit Beteiligung anderer Organsysteme, insbesondere Entwicklung einer Enzephalopathie, unverzüglich ein Transfer in ein Transplantationszentrum indiziert.
The Efficacy of Self-Management Strategies for Females with Endometriosis: a Systematic Review
Authors: Mardon Amelia K. , Leake Hayley B. , Hayles Cathy , Henry Michael L. , Neumann Patricia B. , Moseley G. Lorimer , Chalmers K. Jane 
Published: April 2022

AbstractSelf-management is critical for the care of endometriosis. Females with endometriosis frequently use self-management strategies to manage associated symptoms; however, the efficacy of such strategies is unknown. The aim of this review was to systematically appraise the evidence concerning efficacy of self-management strategies for endometriosis symptoms. Electronic databases, including Medline, Embase, Emcare, Web of Science Core Collection, Scopus, and the Cochrane Central Register of Controlled Trials, were searched from inception to March 2021. We included peer-reviewed experimental studies published in English evaluating the efficacy of self-management strategies in human females laparoscopically diagnosed with endometriosis. Studies underwent screening, data extraction, and risk of bias appraisal (randomised studies: Risk of Bias 2 tool; non-randomised studies: Risk Of Bias In Non-randomized Studies – of Interventions tool). Of the fifteen studies included, 10 evaluated dietary supplements, three evaluated dietary modifications, one evaluated over-the-counter medication, and one evaluated exercise. Most studies had a high-critical risk of bias. Many self-management strategies were not more effective at reducing endometriosis symptoms compared to placebo or hormonal therapies. Where studies suggest efficacy for self-management strategies, no recommendations can be made due to the poor quality and heterogeneity of evidence. High-quality empirical evidence is required to investigate the efficacy of self-management strategies for females with endometriosis.
Machine learning techniques for robotic and autonomous inspection of mechanical systems and civil infrastructure
Authors: Macaulay Michael O. , Shafiee Mahmood 
Published: April 2022

AbstractMachine learning and in particular deep learning techniques have demonstrated the most efficacy in training, learning, analyzing, and modelling large complex structured and unstructured datasets. These techniques have recently been commonly deployed in different industries to support robotic and autonomous system (RAS) requirements and applications ranging from planning and navigation to machine vision and robot manipulation in complex environments. This paper reviews the state-of-the-art with regard to RAS technologies (including unmanned marine robot systems, unmanned ground robot systems, climbing and crawler robots, unmanned aerial vehicles, and space robot systems) and their application for the inspection and monitoring of mechanical systems and civil infrastructure. We explore various types of data provided by such systems and the analytical techniques being adopted to process and analyze these data. This paper provides a brief overview of machine learning and deep learning techniques, and more importantly, a classification of the literature which have reported the deployment of such techniques for RAS-based inspection and monitoring of utility pipelines, wind turbines, aircrafts, power lines, pressure vessels, bridges, etc. Our research provides documented information on the use of advanced data-driven technologies in the analysis of critical assets and examines the main challenges to the applications of such technologies in the industry.
Interdisciplinary analysis of drugs: Structural features and clinical data
Authors: Austin Daniel , Biswas Kumari , Pollock Kailee , Nguyen Linh 
Published: April 2022

Abstract

Background:
Chemical structure is a vital consideration early in the drug development process. Its role in analysis of safety and efficacy is relatively diminished after drugs are approved for clinical use. This interdisciplinary study explores a strategy by which readily available clinical data may be used along with structural features of drugs to identify associations with potential utility for both clinical decision-making and drug development.

Methods:
Chemical functional groups and structural groups (SGs) of 261 drugs were manually classified in tiers, and their incidence of gastrointestinal (GI) and central nervous system (CNS) adverse drug reactions (ADRs) were obtained from a clinical database. Drugs with an GI or CNS ADR incidence of at least 10% were analyzed for correlations with their functional and SGs.

Results:
Eight statistically significant associations were detected by preliminary analysis: piperazine and methylene groups were associated with higher rate of CNS ADRs; while amides, secondary alcohols, and di-substituted phenyl groups were associated with lower rates of GI or CNS ADRs or both.

Conclusions:
Although further study is necessary to understand these associations and build upon this strategy, this exploratory analysis establishes a methodology by which chemical properties of drugs may be used to aid in clinical decision-making when choosing between otherwise equivalent drug therapy options, as the presence of specific groups on drugs may be associated with increased or decreased risks of specific ADRs.
Transmission of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) between hospital workers and members of their household: Nationwide, registry-based, cohort study from Norway
Authors: Elgersma Ingeborg Hess , Telle Kjetil , Elstrøm Petter , Skagseth Håvard , Kacelnik Oliver 
Published: April 2022

AbstractBackground:Understanding and limiting infection in healthcare workers (HCWs) and subsequent transmission to their families is always important and has been underscored during the COVID-19 pandemic. Except in specific and local settings, little is known about the extent of such transmissions at the national level.Objective:To describe SARS-CoV-2 infection in HCWs and to estimate the risk of HCWs transmitting COVID-19 to their household members, including calculating the secondary attack rate to household members and estimating the risk for hospital workers to contract COVID-19 at home.Methods:Using individual-level data on all HCWs employed in Norwegian hospitals and their household members, we identified (1) the number of HCWs who tested positive for SARS-CoV-2 between August 2020 and September 2021 and the proportion of those who were index cases in their own household and (2) the number of HCWs who were secondary cases in their own households.Results:During this period, ∼3,005 (2,6%) hospital workers acquired COVID-19. Almost half of all hospital workers with confirmed COVID-19 were likely index cases in their own households. When the index case in a family was an HCW, the secondary attack rate was 24.8%. At least 17.8% of all confirmed COVID-19 cases among hospital workers were acquired in the household.Conclusions:Our results suggest not only that many HCWs are infected with SARS-CoV-2 in their households but also that infected HCWs constitute a serious infection risk to members of the HCW’s household.
Where You Work Is Where You Stand: A Firm-Based Framework for Understanding Trade Opinion
Authors: Lee Haillie Na-Kyung , Liou Yu-Ming 
Published: April 2022

AbstractWhat determines public support for trade liberalization? Scholars of international political economy have generally focused on the effects of openness on employment via individuals’ skill level, sector, or occupation. Recent developments in trade economics suggest that the characteristics of individual citizens’ employing firms may also shape their attitudes on trade policy. In this paper, using under-explored survey data combining trade opinion with measures of employer productivity (from the 2008 Japanese General Social Survey), we present evidence that employees of more productive, more globalized firms are much more supportive of trade openness than employees of less productive, domestically oriented firms, even when accounting for skill level and sectoral and occupational characteristics. Moreover, we find evidence that the effects of these characteristics described in the literature are conditioned by globalized firm employment. Last, we find that the effect of globalized firm employment is conditioned by employees’ relative position within their firms. Those who are more likely to benefit directly from firm success—such as permanent employees and managers—hold the most pro-trade preferences. These findings suggest that economic interests affect individual policy preferences in more nuanced ways than previously recognized.
Relationship between intake and faecal excretion of indigestible fractions in trials with sheep: impact of the method of analysis, diet and trial
Authors: Pozo C. A. , Mezzomo M. P. , Frasson J. , Leonardi L. E. , Christmann C. M. , Rösler D. C. , Kozloski G. V. 
Published: April 2022

AbstractA data set of individual observations was compiled from 17 digestibility trials with sheep with the aim of evaluating the impact of the method of analysis and, within each method, the effect of dietary fibre content and trial on the faecal recovery rate (RR) of indigestible dry matter (iDM) and indigestible neutral detergent fibre (iNDF). Markers concentration in samples of diet and faeces were determined either in polyester filter bags of 40 μm of porosity incubated in situ for 144 h (method A; n = 257) or in bags of 16 μm of porosity incubated in situ for 288 h (method B; n = 321). Regardless of the incubation method, the intake of either iDM or iNDF was linearly (P < 0.05) related to the amount excreted in faeces and, for all linear relationships, the slopes were lower than 1 (i.e. between 0.53 and 0.71). Within both methods, the RR of both markers linearly decreased at increased NDF content in diet (P < 0.05). The root mean square error of the linear relationships varied from 0.147 to 0.189 which represented from 19% to 24% of the respective average RR of markers. In conclusion, regardless of the incubation method, the RR of both markers showed high individual variability and, thus, the use of average RR values obtained in controlled digestibility trials as an index to correct the individual digestibility values obtained with either marker in field trials has the potential to improve the accuracy but not the precision of the digestibility estimates.