bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Cation Concentration Gradient Approach to Tune the Selectivity and Activity of CO2 Electroreduction
Authors: Ren Wenhao , Xu Aoni , Chan Karen , Hu Xile 
Published: October 2022

AbstractThe linear scaling relationship of the binding energies of different intermediates limits the catalyst performance in CO2 electroreduction. Here we demonstrate a cation concentration gradient strategy to promote the activity and tune the selectivity of CO2 electroreduction, thereby breaking the scaling relationship. In optimal concentrations of the potassium acetate (KAc) electrolyte, Cu, Ag and In catalysts deliver current densities that are 7.1, 3.2, 2.7 times higher than those obtained in 0.5 M KAc for C2H4, CO, and formate production, respectively. Increasing the concentration of KAc also changes the selectivity from CO to formate on Ag, and from CO to C2 products on Cu. In situ surface‐enhanced Raman spectroscopy and computational simulations reveal that the binding energies of intermediates are changed at different electrolyte concentrations, which is due to a local electrostatic interaction modulated by potassium cations at the electrode surface.
Dampened Inflammation and Improved Survival After CXCL5 Administration in Murine Lupus via Myeloid and Neutrophil Pathways
Authors: Fan Xiubo , Ng Chin Teck , Guo Dianyang , Lim Frances , Tan Jia Chi , Law Annie , Goh Lim Hee , Poon Zhi Yong , Cheung Alice , Kong Say Li , Tan Michelle , Li Shang , Loh Alwin , James Anne , Lim Tony , Chen Jinmiao , Thumboo Julian , Hwang William , Low Andrea 
Published: October 2022

ObjectiveTo determine the efficacy of CXCL5 administration in lupus‐prone MRL/lpr (Faslpr) mice and elucidate its working mechanisms.MethodsCXCL5 expression in blood (obtained from SLE patients and Faslpr mice) and major internal organs (obtained from Faslpr mice) was examined by Luminex, real‐time polymerase chain reaction, and immunofluorescent staining analyses. Pharmacokinetic studies were performed in Faslpr mice and healthy Institute of Cancer Research mice. Efficacy of CXCL5 administration was demonstrated in Faslpr mice, and the working mechanism of CXCL5 treatment was elucidated by flow cytometry, Luminex, and RNA sequencing.ResultsIn SLE patients, serum CXCL5 levels were significantly lower than in healthy individuals (P < 0.0001) and negatively correlated with disease activity (P = 0.004). In Faslpr mice, disease severity progressed with age and was negatively associated with plasma CXCL5 levels. Intravenous administration of CXCL5 to Faslpr mice restored endogenous circulatory CXCL5, improved mice survival, and reduced anti–double‐stranded DNA antibodies, proteinuria, lupus nephritis activity and chronicity indices, renal complements, and neutrophil extracellular traps over short‐term (10 weeks) and long‐term (2 years) time periods. In vitro and in vivo assays demonstrated that CXCL5 dictated neutrophil trafficking and suppressed neutrophil activation, degranulation, proliferation, and renal infiltration. Renal and splenic RNA sequencing further showed that CXCL5‐mediated immunomodulation occurred by promoting energy production in renal‐infiltrated immune cells, activating certain T cells, and reducing tissue fibrosis, granulocyte extravasation, complement components, and interferons. Further factorial design results indicated that CXCL5 appears to enhance host tolerability to cyclophosphamide in vulnerable individuals.ConclusionWe found that serum CXCL5 levels were significantly lower in SLE patients than in healthy individuals and were negatively correlated with disease activity. By administering CXCL5 intravenously in a mouse model of lupus, mouse survival improved, and indices of disease activity reduced significantly. Taken together, these findings indicate CXCL5 administration may represent a novel myeloid/neutrophil‐targeting therapy for SLE.
β‐MnOOH nanoplate‐enhanced chemiluminescence reaction and its application to the determination of amoxicillin and salbutamol sulfate
Authors: Iranifam Mortaza , Feizzadeh Maryam 
Published: October 2022

AbstractIn this research, β‐MnOOH nanoplates (NPLs) were hydrothermally produced and then identified using several spectroscopic methods. The β‐MnOOH NPLs were used to catalyze the chemiluminescence (CL) reaction of NaHCO3–H2O2. To validate the capability of the CL reaction for pharmaceutical analysis, the CL reaction of β‐MnOOH NPLs‐NaHCO3‐H2O2 reaction was exploited to develop a new method of measuring antibiotics named amoxicillin (AMX) and salbutamol sulfate (SLB). This method is based on the attenuating β‐MnOOH NPLs‐NaHCO3‐H2O2 CL reaction by the antibiotics. Calibration curves were linear in the range 3.00 × 10−5 to 1.00 × 10−3 mol L−1 for AMX and in the range 1.00 × 10−5 to 1.00 × 10−4 mol L−1 for SLB. The limits of detections obtained using the CL method for AMX and SLB were 8.90 × 10−6 mol L−1 and 5.60 × 10−6 mol L−1, respectively. The relative standard deviations for AMX and SLB, at the 5.00 × 10−5 mol L−1 concentration, were 2.44% and 2.57% (n = 5), respectively. The study of the effect of foreign species showed that the CL method developed has the appropriate selectivity for AMX and SLB. The success of the CL method in actual samples analysis was demonstrated by accurately measuring the selected antibiotics in the pharmaceutical formulations.
Carbon emissions, corporate governance, and hostile takeover threats
Authors: Tanthanongsakkun Suparatana , Kyaw Khine , Treepongkaruna Sirimon , Jiraporn Pornsit 
Published: October 2022

AbstractExploiting a unique measure of takeover vulnerability principally based on state legislations, we investigate how corporate carbon reduction efforts are influenced by the takeover market, which is widely regarded as a crucial instrument of external corporate governance. Our results show that more takeover exposure brings about significantly greater efforts to reduce carbon emissions. A rise in takeover susceptibility by one standard deviation improves carbon reduction performance by 12.81%. The findings corroborate the notion that the takeover market, acting as an external governance mechanism, compels managers to adopt policies that benefit shareholders in the long run. Our results imply that carbon emissions are a crucial corporate outcome as it is subject to the pressure from the takeover market. Companies should pay a close attention to this matter. Further analysis robustly validates the results, including propensity score matching, entropy balancing, an instrumental variable analysis, and heteroscedastic identification. Our measure of takeover vulnerability is plausibly exogenous and thus probably reveals a causal effect, rather than a mere association.
Socioeconomic disparities in cancer survival: Relation to stage at diagnosis, treatment, and centralization of patients to accredited hospitals, 2005–2014, Japan
Authors: Odani Satomi , Tabuchi Takahiro , Nakaya Tomoki , Morishima Toshitaka , Nakata Kayo , Kuwabara Yoshihiro , Saito Mari Kajiwara , Ma Chaochen , Miyashiro Isao 
Published: October 2022

AbstractBackgroundCancer survival varies by socioeconomic status in Japan. We examined the extent to which survival disparities are explained by factors relevant to cancer control measures (promoting early‐stage detection, standardizing treatment, and centralizing patients to government‐accredited cancer hospitals [ACHs]).MethodsFrom the Osaka Cancer Registry, patients diagnosed with solid malignant tumors during 2005–2014 and aged 15–84 years (N = 376,077) were classified into quartiles using the Area Deprivation Index (ADI). Trends in inequalities were assessed for potentially associated factors: early‐stage detection, treatment modality, and utilization of ACH (for first contact/diagnosis/treatment). 3‐year all‐cause survival was computed by the ADI quartile. Multivariable Cox regression models were used to assess survival disparities and their trends through a series of adjustment for the potentially associated factors.ResultsDuring 2005–2014, the most deprived ADI quartile had lower rates than the least deprived quartile for early‐stage detection (42.6% vs. 48.7%); receipt of surgery (58.1% vs. 64.1%); and utilization of ACH (83.5% vs. 88.4%). While rate differences decreased for receipt of surgery and utilization of ACH (Annual Percent Change = −3.2 and − 11.9, respectively) over time, it remained unchanged for early‐stage detection. During 2012–2014, the most deprived ADI quartile had lower 3‐year survival than the least deprived (59.0% vs. 69.4%) and higher mortality (Hazard Ratio [HR] = 1.32, adjusted for case‐mix): this attenuated with additional adjustment for stage at diagnosis (HR = 1.23); treatment modality (HR = 1.20); and utilization of ACH (HR = 1.19)ConclusionsDespite improvements in equalizing access to quality cancer care during 2005–2014, survival disparities remained. Interventions to reduce inequalities in early‐stage detection could ameliorate such gaps.
Lipskynoids A–G, New Acyclic Diterpenes from the Flowers ofCarpesium lipskyi
Authors: Zhong Weihong , Li Min , Gu Rui , Ding Rong , Cao Lan , Mu Zejing , Du Xiaolang , Feng Yulin , Wei Rongrui , Zhan Liujuan , Zhong Guoyue 
Published: October 2022

AbstractSeven new acyclic diterpenes, namely lipskynoids A–G (1–7), were isolated from the flowers ofCarpesium lipskyi, a traditional Tibetan herbal medicine with anti‐inflammatory and antipyretic‐analgesic effects. These new compounds were elucidated by analysis of extensive spectroscopic data including ESI‐MS, 1D, 2D NMR, and DP4+ analyses. Biological assays showed that1–7display significant inhibitory effects against the NO production in LPS‐induced RAW264.7 cells with its IC50values from 9.9 to 18.47 μM, however, no cytotoxicity effect was observed of these isolates against the growth of HePG2, PC3, DU145, and A549 cells.
Effects of Gly Residue and Cholesterol on the GXXXG‐Mediated Parallel Association of Transmembrane Helices: A Single‐Pair FRET Study
Authors: Yano Yoshiaki , Morise Takayuki , Matsuzaki Katsumi 
Published: October 2022

AbstractSmall residue‐mediated interhelical packing is ubiquitous in helical membrane proteins: however, the lipid dependence of its stability remains unclear. We previously demonstrated that the introduction of a GXXXG sequence in the middle of de novo‐designed (AALALAA)3 helices (AALALAA AGLALGA AALALAA) facilitated their dimerization, which was abolished by cholesterol. Here single‐pair FRET measurements revealed that a longer GXXXGXXXG segment (AALALAA A GLALGA AAGALAA) promoted helix dimerization in POPC/cholesterol bilayers, but not without cholesterol. The predicted dimer structures and degrees of helix packing suggested that helix dimers with small (∼10°) and large (∼55°) crossing angles were only stabilized in POPC and POPC/cholesterol membranes, respectively. A steric hindrance in the dimer interface and the large flexibility of helices prevented the formation of stable dimers. Therefore, amino acid sequences and lipid compositions distinctively constrain stable dimer structures in membranes.
PERFORMANCE 1 study: Novel carotid stent system with integrated post‐dilation balloon and embolic protection device
Authors: Langhoff Ralf , Petrov Ivo , Kedev Sasko , Milosevic Zoran , Schmidt Andrej , Scheinert Dierk , Schofer Joachim , Sievert Horst , Sedgewick Gerald , Saylors Elizabeth , Sachar Ravish , Cremonesi Alberto , Micari Antonio 
Published: October 2022

AbstractObjectivesThe PERFORMANCE I study was designed to evaluate the safety and feasibility of the Neuroguard IEP® System, a novel carotid stent system with an integrated embolic filter and post‐dilatation balloon, to treat clinically significant carotid artery stenosis.BackgroundThe risk of major adverse events during carotid artery stenting is comparable to carotid endarterectomy, however, the risk of minor stroke remains higher with stenting.MethodsIn total, 67 patients undergoing carotid artery stenting were enrolled at nine centers in Europe. Follow‐up assessments included neurological exams, duplex ultrasound, 12‐lead electrocardiogram, and cardiac enzyme analysis. The primary endpoint was the 30‐day composite rate of stroke, death, and myocardial infarctions versus a prespecified performance goal. Secondary endpoints included procedure success, device success, and target lesion revascularization.ResultsThe study population was predominantly male (74.6%) with a mean age of 69.3 ± 8.9 years and 67% of subjects met at least one criterion placing them at an elevated risk for adverse events following carotid endarterectomy. All patients were treated successfully with the study device. There were no deaths or strokes within 30 days of the index procedure. One subject (1.5%) experienced a non‐ST elevation myocardial infarction at day 17. The primary endpoint was met with a 30‐day major adverse events rate of 1.5% (1/67). Through 12‐month follow‐up, there were no strokes, neurological deaths, target lesion revascularizations, or instances of in‐stent‐restenosis.ConclusionsResults from this study demonstrate the Neuroguard IEP system is safe and feasible with a stroke/death rate of 0% at 30 days. A large pivotal study is currently underway.
Single‐access for Impella‐supported percutaneous coronary intervention using a sheathless technique with an 8 Fr guide
Authors: Verreault‐Julien Louis , Shekiladze Nikoloz , Wollmuth Jason , Rinfret Stéphane 
Published: October 2022

AbstractComplex and higher‐risk indicated percutaneous coronary interventions at times require mechanical circulatory support, most often with Impella devices. The use of such devices traditionally required additional arterial access site(s), increasing risk of vascular complications. The Single‐access for Hi‐risk percutaneous coronary intervention (SHiP) technique was described to overcome this issue but was limited to the use of 7F guides. Larger 8F guides often provide incremental support and space compared to 7F guides, sometimes needed in complex procedures. We described a modified SHiP technique using an 8 Fr guide delivered sheathless using Rotaglide.
Li2Ba4Al2Ta2N8O, the First Barium Nitridoalumotantalate with BCT‐Zeolite Type Structure
Authors: Wimmer Daniel S. , Seibald Markus , Baumann Dominik , Wurst Klaus , Huppertz Hubert 
Published: October 2022

AbstractSingle‐crystals of Li2Ba4Al2Ta2N8O:Eu2+ were synthesized from Ba3N2, Al2O3, Li3N, Eu2O3, and lithium metal by a high‐temperature solid‐state reaction in a weld shut tantalum ampule. The crystal structure of Li2Ba4Al2Ta2N8O was determined by single‐crystal X‐ray diffraction and it crystallizes in the orthorhombic space group Pnnm (no. 58) with the lattice parameters a=1006.71(3), b=1026.58(3), c=607.10(2) pm, and a volume of V=0.62742(3) nm3. The compound is built up from AlN4 and TaN4 tetrahedra, which form a three‐dimensional network corresponding to the BCT‐zeolite type structure. Li2Ba4Al2Ta2N8O is homeotypic to Li2Sr4Si4N8O and Li2Sr4Al2Ta2N8O but, additionally, it could be successfully doped with the activator ion Eu2+ and hence features an experimental observed overall emission at λmax=565 nm (fwhm=89 nm) consisting of a superposition of two adjusted emission bands at λmax=557 nm (fwhm=69 nm) and at λmax=604 nm (fwhm=102 nm).
PET Imaging of Self‐Assembled 18F‐Labelled Pd2L4 Metallacages for Anticancer Drug Delivery
Authors: Cosialls Raúl , Simó Cristina , Borrós Salvador , Gómez‐Vallejo Vanessa , Schmidt Claudia , Llop Jordi , Cuenca Ana B. , Casini Angela 
Published: October 2022

AbstractTo advance the design of self‐assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F‐labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio‐analytical methods support the formation of the host‐guest cage‐cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP‐MS ex vivo.
Multiply Twisted Chiral Macrocycles Clamped by Tethered Binaphthyls Exhibiting High Circularly Polarized Luminescence Brightness
Authors: Hasegawa Masashi , Hasegawa Chika , Nagaya Yuki , Tsubaki Kazunori , Mazaki Yasuhiro 
Published: October 2022

AbstractInvited for the cover of this issue are Masashi Hasegawa and co‐workers at Kitasto University and Kyoto Prefectural University. The image depicts the reported multiply twisted chiral macrocycles as objects in a kaleidoscope. Read the full text of the article at 10.1002/chem.202202218.
A Potent Auto‐Umpolung Ligand for Conjugative Radical Stabilization
Authors: Holthoff Jana M. , Engelage Elric , Ruff Adrian , Galazzo Laura , Bordignon Enrica , Huber Stefan M. , Weiss Robert 
Published: October 2022

AbstractCarbenes with conjugatively connected redox system act as “auto‐umpolung” ligands. Due to their electronic flexibility, they should also be particularly suitable to stabilize open‐shell species. Herein, the first neutral radical of such sort is described in form of a dialkylamino‐substituted bis(dicyanomethylene)cyclopropanide. Despite the absence of steric shielding, the radical is stable for an extended amount of time and was consequently characterized in solution via EPR measurements. These data and accompanying X‐ray structural analyses indicate that the radical species is in equilibrium with aggregates (formed via π‐stacking) and dimers (obtained via σ‐bond formation between methylene carbons).
Infectious events in pediatric patients with acute lymphoblastic leukemia/lymphoma undergoing evaluation for fever without severe neutropenia
Authors: Patel Pratik A. , DeGroote Nicholas P. , Jackson Kasey , Cash Thomas , Castellino Sharon M. , Jaggi Preeti , Esbenshade Adam J. , Miller Tamara P. 
Published: October 2022

AbstractBackgroundInfections cause significant treatment‐related morbidity during pediatric acute lymphoblastic leukemia/lymphoma (ALL/LLy) therapy. Fevers during periods without severe neutropenia are common, but etiologies are not well‐described. This study sought to describe the bloodstream infection (BSI) and non‐BSI risk in children undergoing therapy for ALL/LLy.MethodsDemographic and clinical data were abstracted for febrile episodes without severe neutropenia at two children's hospitals. Treatment courses were stratified by intensity. Multivariate logistic regression evaluated characteristics associated with infection.ResultsThere were 1591 febrile episodes experienced by 524 patients. Of these, 536 (34%) episodes had ≥1 infection; BSI occurred in 30 (1.9%) episodes. No BSIs occurred in episodes with a recent procedural sedation or cytarabine exposure. Presence of hypotension, chills/rigors, higher temperature, and infant phenotype were independently associated with BSI (p < .05). Of the 572 non‐BSIs, the most common was upper respiratory infection (URI) (n = 381, 67%). Compared to episodes without infection, URI symptoms, higher temperature, absolute neutrophil count 500−999/μl, and evaluation during a low‐intensity treatment course were more likely to be associated with a non‐BSI (p < .05) and inpatient status was less likely to be associated with a non‐BSI (p < .05).ConclusionsThe BSI rate in pediatric patients with ALL/LLy and fever without severe neutropenia is low, but one‐third of the time, patients have a non‐BSI. Future research should test if the need for empiric antibiotics can be tailored based on the associations identified in this study.
Morphology and structure of lead‐free CuSb‐based double perovskites for photocatalytic CO2 reduction
Authors: Wu Daofu , Tian Changqing , Zhou Jingchen , Huang Yanyi , Lai Junan , Gao Bo , He Peng , Huang Qiang , Tang Xiaosheng 
Published: October 2022

AbstractLead‐free halide double perovskites (DPs) have attracted great attention due to their stability, nontoxicity, and good photophysical properties. Herein, environmentally friendly small‐bandgap Cs2CuSbCl6 and Cs4CuSb2Cl12 DPs microcrystals (MCs) are prepared via a solvent synthesis technique. This study also reports a bottom‐up synthetic protocol for obtaining evenly distributed Cs2CuSbCl6 and Cs4CuSb2Cl12 quantum dots (QDs) utilizing a modified hot injection approach. These MCs and QDs have strong absorption throughout the visible region, indicating that they could be promising light‐absorbing materials as sunlight‐driven photocatalysts. For the first time, the efficient sunlight‐driven photocatalytic CO2 reduction activity of these Pb‐free “green” MCs and QDs has been revealed, and a product yield of 307 μmol g−1 and an electron consumption of 1053 μmol g−1 are achieved by the Cs4CuSb2Cl12 QDs under 3 h irradiation. Our results highlight the potential of this family of materials for photocatalytic applications.
Application of Thermal Spray Coatings in Electrolysers for Hydrogen Production: Advances, Challenges, and Opportunities
Authors: Faisal Nadimul Haque , Prathuru Anil , Ahmed Rehan , Rajendran Vinooth , Hossain Mamdud , Venkatachalapathy Viswanathan , Katiyar Nirmal Kumar , Li Jing , Liu Yuheng , Cai Qiong , Horri Bahman Amini , Thanganadar Dhinesh , Sodhi Gurpreet Singh , Patchigolla Kumar , Fernandez Carlos , Joshi Shrikant , Govindarajan Sivakumar , Kurushina Victoria , Katikaneni Sai , Goel Saurav 
Published: October 2022

AbstractThermal spray coatings have the advantage of providing thick and functional coatings from a range of engineering materials. The associated coating processes provide good control of coating thickness, morphology, microstructure, pore size and porosity, and residual strain in the coatings through selection of suitable process parameters for any coating material of interest. This review consolidates scarce literature on thermally sprayed components which are critical and vital constituents (e. g., catalysts (anode/cathode), solid electrolyte, and transport layer, including corrosion‐prone parts such as bipolar plates) of the water splitting electrolysis process for hydrogen production. The research shows that there is a gap in thermally sprayed feedstock material selection strategy as well as in addressing modelling needs that can be crucial to advancing applications exploiting their catalytic and corrosion‐resistant properties to split water for hydrogen production. Due to readily scalable production enabled by thermal spray techniques, this manufacturing route bears potential to dominate the sustainable electrolyser technologies in the future. While the well‐established thermal spray coating variants may have certain limitations in the manner they are currently practiced, deployment of both conventional and novel thermal spray approaches (suspension, solution, hybrid) is clearly promising for targeted development of electrolysers.