bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination therapy based on dual-target biomimetic nano-delivery system for overcoming cisplatin resistance in hepatocellular carcinoma
Authors: huang yufen , Kou Qinjie , Su Yanrong , Lu Lu , Li Xisheng , Jiang Haiye , Gui Rong , Huang Rong , Nie Xinmin , Li Jian 
Published: December 2022

Abstract
The clinical use of cisplatin (DDP) is severely restricted because of nonspecific delivery and the induction of serious systemic toxicity. The limited anticancer drug library and the frequent occurrence of multidrug resistance (MDR) have made monotherapy difficult. Strategies to overcome cisplatin resistance and reduce the long-term use of high-dose medicines, as well as strategies for targeted therapy against hepatocellular carcinoma (HCC) are urgently needed. Previous studies revealed that high NOR1 expression in HCC was associated with drug resistance. Herein, a novel, precise drug/siRNA delivery strategy to realize efficient combination chemotherapy-gene therapy is proposed. To pursue this aim, the dual-targeting nanocarrier system A54-RBCm@NLS-Ag-MOFs/DDP/NOR1 shRNA (AR-NADR) was constructed for the treatment of cisplatin resistance in HCC. The core of the nanocarrier system is the NLS peptide-modified Ag-MOFs (NA) synthesized by silver ion (Ag+) and L-histidine loaded with cisplatin and NOR1 shRNA (NADR). The shell part is the A54 peptide inserted into the erythrocyte membrane (AR). Our results show that AR-NADR has efficient internalization by tumor cells owing to its specific binding to the A54 receptors that are abundantly expressed on the surface of HCC cells and the NLS peptide-mediated pathway of nuclear entry. Simultaneously, as a novel smart pH-sensitive nanodrug delivery system (DDS), DDP is more likely to be released in the acidic tumor microenvironment. Moreover, acting as a vector for gene delivery, AR-NADR effectively inhibits tumor drug resistance by dramatically suppressing the expression of NOR1, which induces intracellular DDP accumulation and makes cells sensitive to DDP. Finally, the anti-HCC efficacy and mechanisms of AR-NADR were systematically elucidated by a HepG2/DDP cell model as well as a tumor model. AR-NADR exhibits critical antitumor efficiency and good biocompatibility. Therefore, AR-NADR constitutes a significant strategy to achieve excellent gene silencing efficacy and antitumor efficacy, which provides effective gene therapy and precise treatment strategies for cisplatin resistance in HCC.
WITHDRAWN: Highly improved UV-shielding and mechanical properties of UV-curable epoxy acrylate nanocomposites by incorporating functionalized aramid nanofibers
Authors: Wang Ying , Luo Yuexin , Pan Yuankai , Ji Chunnuan , Zhang Ying , Sun Changmei , Qu Rongjun 
Published: December 2022

Abstract
Introducing nanofillers into UV-curable coatings can not only effectively improve the performance of the coating but also impart new functions to the film. Herein, methacrylate-functionalized aramid nanofibers (mANFs) were constructed by a bottom-up approach, and their influence on the performance of UV-curable epoxy acrylate (EA) coatings was investigated. The microstructure of the EA/mANF nanocomposite was studied using X-ray Diffraction and Transmission Electron Microscopy (TEM), which confirmed the homogeneous distribution of mANFs in the matrix. The effect of mANFs on the curing kinetics was investigated. The result showed that the photopolymerization rate and final C = C bond conversion would not be adversely affected until more than 0.1 wt % mANFs were added. The UV–vis analyses showed that the EA/mANF films maintained high transmittance in the visible light region and exhibited improved UV-shielding performance. The mechanical characteristics of EA/mANF films were significantly improved by mANFs because of strong interactions such as π–π interactions, hydrogen bonds, and chemical bonds between the matrix and mANFs. For the nanocomposite containing 0.025 wt % mANFs, tensile strength and strain at break increased by 53% and 446%, respectively, compared to neat EA. Thus, the introduction of mANFs considerably improved the mechanical performance of UV-curable EA films and expanded their application in the field of UV shielding.
High Fidelity GAN Inversion with Condition Reiteration for Image Editing
Authors: Dere Vedant , Shinde Amita , Vast Prachi 
Published: December 2022

Abstract
We present an extension to High-Fidelity GAN Inversion(HFGI) that enables us to invert efficitevely image specificdetails (like background, appearance, etc.) in restoringand editing of normal images as well as out of the domainimages (e.g. Heavy makeup faces). We analyzed W+ latentcodes are low dimensional that harden to preserve imagespecific details in restoration. In HFGI encoder, singlestage conditional latents maps are used for invertingimages which restores image specific details with lowconfidence. So in a restored image the low confidenceregion becomes blurry. Also in editing images, detailedinformation is getting lost due to latent navigation. Hencewe propose a reiterative conditional latents method thatenables us to restore image specific details with sharpnesswithout changing the architecture of HFGI. The overallprocess consists of two stages of iterations. First stage willreconstruct the image and the second stage will work onimage specific details using conditional latent codes. Inediting images, we are applying an editor in the first stageonly which will edit latents and in the second stage imagespecific details becomes sharp by conditional latent maps.Our model is also able to invert out of the domain imageswhile preserving all the details. We support InterfaceGAN,GANspace, StyleClip for editing. Moreover we compare ourapproach with the state of the art GAN inversion methodson FFHQ and Stanford Cars Dataset, qualitatively andquantitatively. The results shows significant improvement ininversion and editing quality.
Adsorption of thioindole as a biologically active anti-cancer to C 20 fullerene in different reaction media using density functional theory
Authors: Mohammadi Marziyeh 
Published: December 2022

Abstract
The reaction media effects on interaction of commercially available asymmetric thioindole; (E)-3-(1H-pyrrole-2-yl)methylene-indoline-2-thione (I) as a selective and potent inhibitor of tyrosine kinase; to C20 nanocage are studied at DFT. We have tackled this inter-molecular adsorption using the PCM-SCRF method in the gas phase, cyclohexane, CHCl3, MeOH, H2O, acetonitrile and DMSO. We completely optimized the scrutinized initial structures, transition states (TSs) and product (Ia) in the different reaction media and then compared and contrasted their properties. Stability of I solute and Ia complex depends on the dielectric constant of the used solvent (ε), the possibility of the hydrogen bonding (HB) and dipole–dipole interaction between them. In going from the gas phase to less polar solvent, then in turn to more polar solvent, a good consistency appears between ε and the absolute value of adsorption energy difference among liquid phase and gas phase i.e. │∆El-g│ obtained for Ia product. Moreover, the highest │∆El-g│ is measured for Ia in water, whereas the lowest value is associated in cyclohexane. Because of capability of HB, Ia is stabilized in the most polar solvent (water) more than gas phase and other solvents. The kinetic stability and energy difference between the frontier orbitals (∆EL-H) is observed in the opposite direction with ε. The π-π aromatic stacking between I and C20 leads to destabilization of endo TS. Dipole-pole interaction between I and more polar solvent, leads to more stability of exo TS and Ia in water solvent. The activation energy of exo and endo TSs (Eexo≠ and Eendo≠) in the studied reaction media is followed as H2O > DMSO > acetonitrile > MeOH > CHCl3 > cyclohexane > gas phase. The highest Eexo≠ and Eendo≠ is found in water. Evidently, the most and the least kinetically stable exo and endo TS is suggested for adsorption in water and gas phase, respectively.
ScAlN film-based piezoelectric micromechanical ultrasonic transducers with dual-ring structure for distance sensing
Authors: Li Jiadong , zhang yuchao , Miao Bin , Wang Guanghua , Zhou Hongyu , Zhang Shiqin , Hu Yimin , Wu Junfeng , Yu Xuechao 
Published: December 2022

Abstract
Piezoelectric micromechanical ultrasonic transducers (pMUTs) are a new type of distance sensors with great potential for applications in automotive, unmanned aerial vehicle, robotics, and smart-home. However, the previously reported pMUT is limited by short sensing distance due to lower output sound pressure. In this work, a pMUT with a special dual-ring structure based on scandium-doped aluminum nitride (ScAlN) is proposed. The combination of a dual-ring structure with pinned boundary conditions and a high piezoelectric performance ScAlN film allows the pMUT to achieve a large dynamic displacement of 2.87 μm/V and a high electromechanical coupling coefficient (k2t) of 8.92%. The results of the ranging experiments show that the proposed pMUT achieves a 6 m distance sensing, the farthest distance sensing up to date registered. This pMUT provides surprisingly fertile ground for various distance sensing applications.
In-Silico Analysis of Active Compounds from Herbal Plants Against Penicillin Binding Protein 2a (PBP2a) of Methicillin-Resistant Staphylococcus Aureus
Authors: Maulana Rafiq Usdiqa , Wardani Agustin Krisna , Utami Cinthya Putri 
Published: December 2022

Abstract

Herbal plants are frequently used for medication by people as they contain rich bioactive compounds. Turmeric (Curcuma longa) and bitter ginger (Zingiber zerumbet) are types of rhizome herbal plants with the highest amount of production in Indonesia. They contain bioactive compounds applicable for antibiotics against resistant bacteria, one of which is MRSA (Methicillin-resistant Staphylococcus aureus). This study aims to investigate the compound components in turmeric and bitter ginger, which might be anti-MRSA candidates against the PBP2a binding side by in-silico analysis. A total of 24 ligands of turmeric and bitter ginger are bound to the target protein, the PBP2a receptor. The binding results are followed with a test of biological activity, physicochemical properties, and toxicity of the herbal plant compounds. The study resulted in 12 ligands potentially being anti-MRSA with binding on the allosteric side of PBP2a. In sum, it suggested three compounds with the best potential for anti-MRSA candidates: curcumin, germacrone, and zerumbone and may be considered as drug candidates for therapeutic aims in several human infections associated with MRSA. Nevertheless, in vitro and in vivo confirmations are needed.
Accumulation of Na+ in cotton field under mulched drip irrigation of brackish water in arid areas
Authors: Dong Rui , Liu Wenkai , Qu Jihong 
Published: December 2022

Abstract
In arid areas, the disordered accumulation of Na+ in cotton fields under mulched drip irrigation seriously affects the normal growth and development of cotton. To reveal the process and mechanism of Na+ accumulation, in-situ field tests were conducted in typical cotton planting bases in the south of Xinjiang, China. Eight experimental scenarios were set up to use brackish and fresh water for drip irrigation under mulch during the whole growth period of cotton according to the drip irrigation system. By monitoring the weather, groundwater level, and soil moisture before and after irrigation, and testing the soil salinity and Na+ concentration, the temporal and spatial distribution and transport characteristics of Na+ were compared and studied. The results showed that: (1) owing to the strong spatial variation of soil permeability, soil water and salt dynamics exhibited significant differences after irrigation in all experimental scenarios in the study area, especially at a depth of 0–60 cm. (2) The Na+ profile exhibited a “thin waist”, whose depth depended on the climate and lithology of the soil; however, this phenomenon was not observed in the salt profile. (3) The accumulation of Na+ in cotton fields is an extremely complex dynamic process that is influenced by both natural and human activities. This process is controlled by the dynamic characteristics of soil water and salt, but it is different from the distribution of soil salt in time and space. This study provides necessary technical support for the formulation of drip irrigation systems under brackish water film, and provides a scientific basis for fine agricultural planting and water resources management in arid areas.
WITHDRAWN: HO-1 may be the potential therapeutic target for Atopic dermatitis as oxidative stress is dysregulated and associated with inflammation in Atopic dermatitis patients
Authors: Yuan Jinping , Wang Xiyi , Yu Huiwen , Xu Lei , Wu Xiaoyu , Mao Mengmeng , Bai Bing-Xue 
Published: December 2022

Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease and oxidative stress plays pathogenetic role in it. Heme oxygenase-1 (HO-1) is a key enzyme in response to oxidative and inflammatory insults. This study aims to evaluate the correlation between HO-1 expression, oxidative stress and inflammation in AD patients, identify the antioxidative and anti-inflammation effects of HO-1 on H2O2-induced HaCaT cells. Forty-two AD patients and twelve healthy controls were enrolled. Human Oxidative Stress PCR Array was performed to test the oxidative stress related gene expression in AD patients and controls. The HO-1 expression, malondialdehyde (MDA) and SOD and inflammatory factors IL-4 and high mobility group box1 (HMGB1) were measured by ELISA. The effect of HO-1 on the expressions of ROS, MDA and SOD, and inflammatory factors IL-4 and TNF-α were also detected in H2O2-induced HaCaT cells. We demonstrated that the levels of MDA were increased while SOD, antioxidants genes, ROS metabolisms and oxygen transporter genes were decreased in AD patients than in controls. In addition, high expression of MDA is positively correlated with IL-4 expression and disease severity of AD. HMGB1was also positively correlated with SOD activity. Furthermore, the level of HO-1 was significantly higher in AD patients than controls and HO-1 increased the SOD activity and decreased the levels of ROS, MDA, decreased the expressions of IL-4 and TNF-α in H2O2 -induced oxidative stress in HaCaT cells. In conclusion, oxidative damage is positively correlated with inflammatory factors and disease severity of AD and HO-1 may be potential target as its antioxidant and anti-inflammation effects.
Reference Correlation for the Viscosity of Ethanol from the Triple Point to 620 K and Pressures up to 102 MPa
Authors: Sotiriadou Sofia , Ntonti Eleftheria , Velliadou Danai , Antoniadis Konstantinos D. , Assael Marc , Huber Marcia L. 
Published: December 2022

Abstract
We present a wide-ranging correlation expressed in terms of temperature and density for the viscosity of ethanol based on critically evaluated experimental data. The correlation is designed to be used with an existing equation of state from the triple point (159 K) to 620 K and at pressures up to 102 MPa. Comparisons with experimental data indicate the estimated uncertainty of the correlation is 4.2 % (at the 95% confidence level) for the liquid and supercritical phase at pressures up to 102 MPa, and 2% in the gas phase. Furthermore, for calculating viscosity values at 0.1 MPa, an additional correlation is proposed, valid from the triple point to the boiling point with an estimated uncertainty of 2.3 % (at the 95% confidence level).
The increased monocytic myeloid-derived suppressor cells in type 2 diabetes corelate with hyperglycemic and was a risk factor of infection and tumor
Authors: Zhou Ji , Zhang Mengjie , Ju Xiaodi , Wang Huiping , Hao Xiao , Zhai Zhimin , Zhong Xing , Hong Jingfang 
Published: December 2022

Abstract
Background
To explore the M-MDSCs frequency in T2DM patients and whether it is corelated to the glycaemia, infection and tumor development.
Methods
We recruited healthy volunteers and T2DM patients for this study. M-MDSCs frequency in the peripheral blood, FPG, HbA1c levels, and other relevant indicators were detected. T2DM patients were further divided into good glycaemic control (GGC) and poor control (PGC) groups, and each patient was followed up for at least 6 months after the M-MDSCs were tested. We then analysed and compared the M-MDSCs frequency in the healthy population to various subgroups of T2DM patients, as well as the associations between M-MDSCs, glycaemia, infection, and tumor development.
Results
The M-MDSCs frequency was significantly higher in T2DM patients with PGC than in the healthy population (2.54% vs 0.93%), but there was no significant difference between patients with GGC and the healthy group (P > 0.05). The M-MDSCs frequency was positively correlated with FPG and HbA1c levels (R = 0.517 and 0.315, respectively). In addition, the patients who had tumors had the highest M-MDSCs number (12.89%), vastly more than those in the patients who only had an infection (3.14%) and the patients who had neither infection nor tumor (1.95%). When M-MDSCs frequency was higher than 2.8% or 11.24%, the risk ratios for infection or tumor occurrence were 2.5-fold and 43.2-fold higher in T2DM patients, respectively.
Conclusions
Elevated M-MDSC levels are associated with hyperglycaemia and may be a useful indicator for predicting the risk of infection or tumor development in T2DM patients.
Mir-330-3p alleviates the progression of atherosclerosis through downregulating AQP9
Authors: Shan Erbo , Yu Yuanyuan , Tang Wenbo , Wang Wei , Wang Xiangkui , Zhou Shaobo , Gao Yong 
Published: December 2022

Abstract
Atherosclerosis is one of the main causes of cardiovascular diseases. Aquaporin 9 (AQP9), a triglyceride channel is permeable to water, monocarboxylic acids, glycerol and lactic acid. However, the role of AQP9 in atherosclerosis is not clear. In present study, we predicted that miR-330-3p might regulate AQP9 in atherosclerosis through bioinformatics analysis, then we established atherosclerosis model by ApoE −/− mouse (C57BL/6) with high fat diet (HFD). Hematoxylin and eosin (H&E) and Oil red O were used to stain atherosclerotic lesions. Furthermore, we used 100 µg/mL ox-LDL treat human umbilical vein endothelial cells (HUVECs) to investigate the role of miR-330-3p and AQP9. CCK8 and EDU assays were used to investigate the cell proliferation. Wound scratch healing and transwell assays were used to measure the cells invade and migrate ability. Flow cytometry assay was used to detect apoptosis and cell cycle changes. A dual-luciferase reporter assay was performed to determine the binding of miR-330-3p and AQP9. We identified that the expression of miR-330-3p in AS mice model decreased while the expression of AQP9 increased. MiR-330-3p overexpression or down-regulation of AQP9 could reduce cell apoptosis and promote cell proliferation and migration after ox-LDL treatment. Dual-luciferase reporter assay result presented that AQP9 is directly inhibited by miR-330-3p. These results suggest that miR-330-3p inhibits atherosclerosis by regulating AQP9. Our results indicates that miR-330-3p inhibits atherosclerosis by regulating AQP9. Mir-330-3p/AQP9 axis maybe a new therapeutic target for atherosclerosis.
Modeling and optimization of coagulation-flocculation process to remove high phosphate concentration in wastewater from a metal-mechanic industry
Authors: Gómez-Rodríguez Carlos , Gómez-Castro Fernando Israel , Gamiño-Arroyo Zeferino , Pérez Tzayam 
Published: December 2022

Abstract
In this work, the performance of a coagulation-flocculation plant to treat wastewater from a metal-mechanic industry located in an industrial park of Queretaro city, Mexico is studied. Wastewater samples were obtained from the homogenization tank and treated with the employed industrial reactants through an experimental jar test to obtain statistical data. Then, a response surface methodology with ANOVA analysis was used to model the process, and the ε-constraints methodology was used to optimize the coagulation-flocculation process in terms of economic and environmental impact. Optimal operating conditions were found at 400 mg L− 1 of calcium hydroxide dose, 0.723 mL L− 1 of aluminum salts dose, 3.32x10− 3 mg L− 1 flocculant dose and 100 rpm of agitation speed. The results showed an improvement of phosphates removal, but a minimal increment of 1.01% of operational costs regarding to the current operating conditions.
Etiological analysis and Treatment Principles of Atypical Femur Fracture
Authors: Zhang Zhishan , Wang Hongqing , Zhou Fang , Tian Yun , Song Chunli , Yang Zhongwei , Hou Guojin 
Published: December 2022

Abstract
Purpose: To investigate the etiology, clinical characteristics and treatment of atypical femur fracture (AFF) and to improve AFF recognition.
Methods: The clinical data of 21 AFF patients treated in our hospital from January 2007 to June 2021 were retrospectively analyzed, and the clinical characteristics of AFF were summarized. 47 patients with the same age, gender and location of fracture were selected to establish the control group. The patients were classified according to the risk factors, and the clinical characteristics of AFFs were summarized.
Results: 21 patients (27 femurs, six bilateral femurs) included 17 females, with an average age of 66.59±13.52 years (rang, 32-85 years). Through the relative risk analysis, it was judged that the long-term application of bisphosphonates (BPs) was the risk factor for the occurrence of AFFs. Using principal components analysis, it was concluded that severe osteoporosis, hip joint dysfunction and structural abnormality of the femur were also the risk factors for the occurrence of AFFs. A total of 5 patients with non-surgical treatment were selected, of which 2 cases were cured and the remaining 3 cases underwent surgical treatment. A total of 21 femurs for intramedullary nail fixation and 4 femurs for plate fixation. All fractures healed.
Conclusions: The etiological factors of atypical femur fracture are complex.For high-risk patients, if there are prodromal symptoms or imaging examination indicates "simple transverse" femur fracture, it is necessary to be alert to the occurrence of AFF, and pay attention to whether there is AFF on the opposite side. The appropriate treatment will be chosen according to the characteristics of fracture.
Spatial modeling of flood hazard using machine learning and GIS in Ha Tinh province, Vietnam
Authors: Nguyen Huu Duy 
Published: December 2022

Abstract
The objective of this study was the development of an approach based on machine learning and GIS, namely Adaptive Neuro-Fuzzy Inference System (ANFIS), Gradient-Based Optimizer (GBO), Chaos Game Optimization (CGO), Sine Cosine Algorithm (SCA), Grey Wolf Optimization (GWO), and Differential Evolution (DE) to construct flood susceptibility maps in the Ha Tinh province of Vietnam. The database includes 13 conditioning factors and 1,843 flood locations, which were split by a ratio of 70/30 between those used to build and those used to validate the model, respectively. Various statistical indices, namely root mean square error (RMSE), area under curve (AUC), mean absolute error (MAE), accuracy, and R1 score, were applied to validate the models. The results show that all the proposed models performed well, with an AUC value of more than 0.95. Of the proposed models, ANFIS-GBO was the most accurate, with an AUC value of 0.96. Analysis of the flood susceptibility maps shows that approximately 32–38% of the study area is located in the high and very high flood susceptibility zone. The successful performance of the proposed models over a large-scale area can help local authorities and decision-makers develop policies and strategies to reduce the threats related to flooding in the future.