bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous Total Ankle Replacement and Contralateral Ankle Arthrodesis for Bilateral Ankle Osteoarthritis: A Retrospective Study Focused on Clinical Outcomes and Cost‐effectiveness
Authors: Chen Jun , Wu Shizhou , Li Yaxing , Chen Yu , Liu Xi , Qin Boquan , Zhang Hui 
Published: July 2022

ObjectiveTotal ankle replacement (TAR) and ankle arthrodesis (AA) are two common surgical treatment options for end‐stage ankle osteoarthritis. However, few reports compare the outcomes of simultaneous TAR and contralateral AA for bilateral ankle osteoarthritis. The aim of this study was to assess changes in pain, joint range of movement (ROM), functional outcomes, patient satisfaction, and cost‐effectiveness following simultaneous TAR and contralateral AA.MethodsA retrospective study was conducted on 12 patients with bilateral end‐stage ankle osteoarthritis who underwent simultaneous TAR and contralateral AA in our institution between May 2016 and August 2018, and who had a minimum of two‐year follow‐up data. Clinical and radiological follow‐up data for all patients were collected after 4 months, 1 year and 2 years. The results were assessed clinically on a visual analogue scale (VAS) and included ROM, American Orthopedic Foot and Ankle Society (AOFAS) ankle hindfoot score, and satisfaction questionnaire. The total hospital costs of patients were also recorded. Independent sample t tests were conducted to compare continuous variables between groups. Paired sample t‐tests were conducted to compare changes from the preoperative to postoperative evaluations within each group.ResultsBoth surgical groups presented with pain reduction (P < 0.001) at the one‐year postoperative session, which was generally consistent until the two‐year follow‐up. There was a significant increase (P < 0.001) in the mean AOFAS score postoperatively in both ankles. The functional outcomes at the one‐ and two‐year follow‐up were significantly better in patients in the TAR group than in those in the AA group (P < 0.001). Joint ROM differences were observed between the two groups after surgery (decreased ankle ROM in arthrodesis, P < 0.001; increased ankle ROM in arthroplasty, P < 0.001). The mean satisfaction score was 2 (range, 1–4) for the TAR group and 3 (range, 1–5) for the AA group. A significant difference in the satisfaction score was observed between the two groups (P = 0.036). Simultaneous TAR and contralateral AA was 34.1% less expensive than simultaneous bilateral TAR. No intraoperative complications were noted in either group. Wound healing occurred without problems within 2 weeks after surgery. No symptomatic deep venous thrombosis was found during follow‐up.ConclusionTAR had better patient‐perceived post‐operative function and preserves more anatomic sagittal plane motion compared to ankles undergoing AA. In addition, simultaneous TAR and contralateral AA are more cost‐effective than simultaneous bilateral TAR, with lower costs for the average patient.
Acute and long‐term success of left atrial anterior line and mitral isthmus line ablation in patients after mitral valve surgery
Authors: Bertels Jana , Rottner Laura , Heeger Christian‐Hendrik , Maurer Tilman , Reissmann Bruno , Ouyang Feifan , Mathew Shibu , Wohlmuth Peter , Schlüter Michael , Kuck Karl‐Heinz , Metzner Andreas , Lemeš Christine 
Published: July 2022

AbstractBackgroundPerimitral flutter and atrial fibrillation may occur in patients with prior surgical mitral valve (MV) repair or replacement and can be challenging for percutaneous catheter ablation. This study sought to determine the feasibility, acute success and durability of catheter ablation of atrial fibrillation or atrial tachycardia by way of a mitral isthmus line (MIL) or an anterior line (AL).MethodsA total of 81 patients (49 males, mean age 62±11 years) with prior MV replacement (n = 30) or reconstruction (n = 51) underwent creation of a MIL (34) and/or an AL (72).ResultsAcute bidirectional block of the MIL was successfully achieved in 24/34 cases and of the AL in 64/72 patients. Patients of the control group without prior MV surgery were matched 1:1 with the valve group. In the AL control subgroup, acute bidirectional block was achieved in 65/72 patients. Acute blockage in the MIL control subgroup could be achieved in 31/34 patients. The MIL valve subgroup showed the worst results in terms of durability, whereas a similar trend emerged in the control group and the AL valve subgroup (probability of failure in MIL valve subgroup 2.224 vs. MIL control subgroup 0.605 [Hazard Ratio (HR) = 0.27, 95% confidence interval (CI), 0.11–0.65), P = .004]; probability of failure in AL valve subgroup 0.844 vs. AL control subgroup 1.03 [HR = 1.22 (95% CI, 0.66–2.26), P = .523]).ConclusionsPercutaneous creation of MIL and AL is feasible and safe in patients with prior MV replacement/repair and associated with moderate acute and long‐term success rates to achieve bidirectional block.
Sentientism, Motivation, and Philosophical Vulcans
Authors: Roelofs Luke 
Published: July 2022

AbstractIf moral status depends on the capacity for consciousness, what kind of consciousness matters exactly? Two popular answers are that any kind of consciousness matters (Broad Sentientism), and that what matters is the capacity for pleasure and suffering (Narrow Sentientism). I argue that the broad answer is too broad, while the narrow answer is likely too narrow, as Chalmers has recently argued by appeal to ‘philosophical Vulcans’. I defend a middle position, Motivational Sentientism, on which what matters is motivating consciousness: any kind of consciousness which presents its subject with reasons for action.
Alopecia and hyperpigmentation in a neonatal patient with lanosterol synthase gene deficiency and Spectrin alpha, non‐erythrocytic 1 mutation
Authors: Xiao Teresa L. , Rosenblatt Adena E. 
Published: July 2022

AbstractLanosterol synthase is required for cholesterol synthesis, and deficiencies have been associated with hypotrichosis as well as neuroectodermal syndromes including intellectual delay and epilepsy. Here, we report a case of lanosterol synthase deficiency in a 4‐day‐old patient who presented with alopecia and a previously unreported dermatologic manifestation of congenital localized hyperpigmentation.
Temptation at your door: Receiving mate poaching attempts and perceived Partners' desirability
Authors: Birnbaum Gurit E. 
Published: July 2022

AbstractCommitted individuals cope with the threat of alternative partners by using strategies that undermine their allure. However, in an era, in which alternative mates lurk around every corner, these strategies may lose their effectiveness. Two studies investigated this possibility, examining how being the target of online mate poaching influenced perceptions of current and alternative partners. In both studies, partnered undergraduate students chatted online with a confederate of the other sex who behaved either flirtatiously or neutrally. Then, participants completed a measure of implicit perception of their partner (Study 1) or described a sexual fantasy (Study 2). The fantasies were coded for expressions of desire for current and alternative partners. Results showed that receiving mate poaching attempts decreased the appeal of current partners while increasing the desirability of alternatives. These findings demonstrate the circumstances that weaken resistance to temptations, pointing to a route by which online interactions may impair relationship functioning.
Economic costs and health utility values associated with extremely preterm birth: Evidence from the EPICure2 cohort study
Authors: Achana Felix , Johnson Samantha , Ni Yanyan , Marlow Neil , Wolke Dieter , Khan Kamran , Petrou Stavros 
Published: July 2022

AbstractBackgroundPreterm birth is associated with adverse health and developmental sequelae that impose a burden on finite resources and significant challenges for individuals, families and societies.ObjectivesTo estimate economic outcomes at age 11 associated with extremely preterm birth using evidence from a whole population study (EPICure2 study).MethodsThe study population comprised a sample of children born at ≤26 completed weeks of gestation during 2006 in England (n = 200) and a comparison group of classmates born at term (n = 143). Societal costs were estimated using parent and teacher reports of service utilisation, and valuations of work losses and additional care costs to families. Utility scores for the Health Utilities Index Mark 2 (HUI2) and Mark 3 (HUI3) were generated using UK and Canadian value sets. Generalised linear regression was used to estimate the impact of extremely preterm birth on societal costs and utility scores.ResultsUnadjusted mean societal costs that excluded provision of special educational support in mainstream schools during the 11th year after birth were £6536 for the extremely preterm group and £3275 for their classmates, generating a difference of £3262 (95% confidence interval [CI] £1912, £5543). The mean adjusted cost difference was £2916 (95% CI £1609, £4224), including special educational needs provision in mainstream schools increased the adjusted cost difference to £4772 (95% CI £3166, £6378). Compared with birth at term, extremely preterm birth generated mean‐adjusted utility decrements ranging from 0.13 (95% CI 0.09, 0.18) based on the UK HUI2 statistical inference tariff to 0.28 (95% CI 0.18, 0.37) based on the Canadian HUI3 tariff.ConclusionsThe adverse economic impact of extremely preterm birth persists into late childhood. Further longitudinal studies conducted from multiple perspectives are needed to understand the magnitude, trajectory and underpinning mechanisms of economic outcomes following extremely preterm birth.
On the determination and rank for the environmental risk aspects for ship navigating in the Arctic based on big Earth data
Authors: Liu Yang , Ma Xiaoxue , Qiao Weiliang , Han Bing 
Published: July 2022

AbstractThe unique, ambiguous, and complex navigable environment determines the essential difference between Arctic shipping routes and conventional routes in regard to safety issues. To achieve a scientific understanding of the characteristics and variations of environmental risks involved in the Arctic shipping, it is essential to rationally address the uncertainty and incompleteness of environment‐related risk information. In this study, fuzzy evidential reasoning is introduced to carry out multisource heterogeneous data fusion and spatiotemporal dynamic assessment of navigable environmental risks for Arctic shipping routes. Based on big Earth data collected from the European Center for Medium‐Range Weather Forecasts, National Snow And Ice Data Center, National Center for Environmental Information, and University of Bremen from 2012 to 2019, a case study of the Northeast Passage is considered to demonstrate the feasibility of the proposed methodology. Finally, the results are described from three aspects: spatial distribution, temporal changes, and sensitivity analysis, with consideration of the entire passage and five marginal seas at the same time. Based on these findings, the prospect of application of big Earth data in risk assessment is further discussed from two aspects of knowledge acquisition by big data and risk analysis at different scales, to inspire sustainable development of Arctic shipping.
Medical capacity investment for epidemic disease: The effects of policymaker's confidence and public trust
Authors: Chen Xin , Dong Yucheng , Wu Meng 
Published: July 2022

AbstractDue to the server bed shortage, which has raised ethical dilemmas in the earliest days of the COVID‐19 crisis, medical capacity investment has become a vital decision‐making issue in the attempt to contain the epidemic. Furthermore, economic strength has failed to explain the significant performance difference across countries in combatting COVID‐19. Unlike common diseases, epidemic diseases add substantial unpredictability, complexity, and uncertainty to decision‐making. Knowledge miscalibration on epidemiological uncertainties by policymaker's over‐ and underconfidence can seriously impact policymaking. Ineffective risk communication may lead to conflicting and incoherent information transmission. As a result, public reactions and attitudes could be influenced by policymakers' confidence due to the level of public trust, which eventually affects the degree to which an epidemic spreads. To uncover the impacts of policymakers' confidence and public trust on the medical capacity investment, we establish epidemic diffusion models to characterize how transmission evolves with (and without) vaccination and frame the capacity investment problem as a newsvendor problem. Our results show that if the public fully trusts the public health experts, the policymaker's behavioral bias is always harmful, but its effect on cost increment is marginal. If a policymaker's behavior induces public reactions due to public trust, both the spread of the epidemic and the overall performance will be significantly affected, but such impacts are not always harmful. Decision bias may be beneficial when policymakers are pessimistic or highly overconfident. Having an opportunity to amend initially biased decisions can debias a particular topic but has a limited cost‐saving effect.
Equivalence scales in a developing country with extensive inequality
Authors: Koch Steven F. 
Published: July 2022

AbstractThis study estimates food budget share equations to calculate household equivalence scales that incorporate base‐independence and address potential endogeneity, even though an instrument that satisfies the usual exclusion restriction may not be available. The application incorporates semi‐parametric methods, control functions and heteroscedasticity instrumentation, allowing for heterogeneity in household preferences. The application is founded on the most recent income and expenditure data that are available for South Africa. We find that there is extensive heterogeneity and that endogeneity matters. Failing to account for endogeneity leads to overstated equivalence scales in nearly every circumstance. When we fit our calculated scales to a typical
equivalence structure via non‐linear least squares, we find values of
near unity and values of
mostly below 0.5. Thus, our analysis suggests that a square‐root scale is more appropriate than other scales that have been used to examine poverty and inequality in South Africa.
Diagnosis of juvenile idiopathic arthritis with asymptomatic involvement of the temporomandibular joint: A case report
Authors: Ferrazzo Kívia Linhares , Thomas Alexander , Danesi Cristiane Cademartori , Marquezan Mariana , Ferrazzo Vilmar Antonio 
Published: July 2022

AbstractJuvenile idiopathic arthritis (JIA) is a broad term that describes a group of heterogeneous rheumatologic diseases, mainly characterized by inflammation in the joints of children and young people up to 16 years of age. Its etiology is still not well understood and the diagnosis, essentially clinical, begins with the exclusion of other joint diseases. When the disease affects the temporomandibular joint, diagnosis is a challenge, as many patients are asymptomatic. The objective of this paper is to present a case of JIA with severe involvement of the temporomandibular joint and to discuss the clinical, radiographic, laboratory findings and the importance of early diagnosis. The lack of diagnosis of active arthritis in the temporomandibular joint in patients with JIA can cause irreversible effects such as micrognathia, malocclusion and reduced maximum mouth opening. Early diagnosis of temporomandibular joint involvement in JIA is important and needs to be investigated early in the clinical manifestation of systemic disease. Laboratory tests and clinical history are important to define treatment and prognosis, but not to predict temporomandibular joint arthritis. Imaging exams are important diagnostic tools to identify morphological changes in soft and hard tissues of the temporomandibular joint.
Unsupervised and semi‐supervised learning: the next frontier in machine learning for plant systems biology
Authors: Yan Jun , Wang Xiangfeng 
Published: July 2022

SUMMARYAdvances in high‐throughput omics technologies are leading plant biology research into the era of big data. Machine learning (ML) performs an important role in plant systems biology because of its excellent performance and wide application in the analysis of big data. However, to achieve ideal performance, supervised ML algorithms require large numbers of labeled samples as training data. In some cases, it is impossible or prohibitively expensive to obtain enough labeled training data; here, the paradigms of unsupervised learning (UL) and semi‐supervised learning (SSL) play an indispensable role. In this review, we first introduce the basic concepts of ML techniques, as well as some representative UL and SSL algorithms, including clustering, dimensionality reduction, self‐supervised learning (self‐SL), positive‐unlabeled (PU) learning and transfer learning. We then review recent advances and applications of UL and SSL paradigms in both plant systems biology and plant phenotyping research. Finally, we discuss the limitations and highlight the significance and challenges of UL and SSL strategies in plant systems biology.
Potato virus X‐delivered CRISPR activation programs lead to strong endogenous gene induction and transient metabolic reprogramming in Nicotiana benthamiana
Authors: Selma Sara , Gianoglio Silvia , Uranga Mireia , Vázquez‐Vilar Marta , Espinosa‐Ruiz Ana , Drapal Margit , Fraser Paul D. , Daròs José‐Antonio , Orzáez Diego 
Published: July 2022

SUMMARYProgrammable transcriptional regulators based on CRISPR architecture are promising tools for the induction of plant gene expression. In plants, CRISPR gene activation is effective with respect to modulating development processes, such as the flowering time or customizing biochemical composition. The most widely used method for delivering CRISPR components into the plant is Agrobacterium tumefaciens‐mediated genetic transformation, either transient or stable. However, as a result of their versatility and their ability to move, virus‐derived systems have emerged as an interesting alternative for supplying the CRISPR components to the plant, in particular guide RNA (gRNA), which represents the variable component in CRISPR strategies. In the present study, we describe a Potato virus X‐derived vector that, upon agroinfection in Nicotiana benthamiana, serves as a vehicle for delivery of gRNAs, producing highly specific virus‐induced gene activation. The system works in combination with a N. benthamiana transgenic line carrying the remaining complementary CRISPR gene activation components, specifically the dCasEV2.1 cassette, which has been shown previously to mediate strong programmable transcriptional activation in plants. Using an easily scalable, non‐invasive spraying method, we show that gRNA‐mediated activation programs move locally and systemically, generating a strong activation response in different target genes. Furthermore, by activating three different endogenous MYB transcription factors, we demonstrate that this Potato virus X‐based virus‐induced gene reprogramming strategy results in program‐specific metabolic fingerprints in N. benthamiana leaves characterized by distinctive phenylpropanoid‐enriched metabolite profiles.
Role of grapevine SEPALLATA‐related MADS‐box gene VvMADS39 in flower and ovule development
Authors: Zhang Songlin , Yao Jin , Wang Li , Wu Na , van Nocker Steve , Li Zhi , Gao Min , Wang Xiping 
Published: July 2022

SUMMARYSeedlessness is one of the most important breeding goals for table grapes; thus, understanding the molecular genetic regulation of seed development and abortion is critical for the development of seedless cultivars. In the present study, we characterized VvMADS39, a class E MADS‐box gene of grapevine (Vitis vinifera) orthologous to Arabidopsis SEP2. Heterologous overexpression of VvMADS39 in tomato reduced the fruit and seed size and seed number. Targeted mutagenesis of the homologous SlMADS39 in tomato induced various floral and fruit defects. It could reasonable to suppose that active VvMADS39 expression in “Thompson Seedless” may restrict cellular expansion, resulting in the development of smaller fruits and seeds, VvMADS39 may play a role in the regulation of ovule development in grapevine and contributes to seedless fruit formation. In contrast, VvMADS39 suppression in “Red Globe” was associated with enhanced histone H3 lysine 27 trimethylation in the promoter region of VvMADS39, allowing normal ovule and fruit development; Meanwhile, VvMADS39 interacts with VvAGAMOUS, and the activity of the VvMADS39–VvAGAMOUS dimer to induce integument development requires the activation and maintenance of VvINO expression. The synergistic cooperation between VvMADS39 and related proteins plays an important role in maintaining floral meristem characteristics, and fruit and ovule development.
Human T‐lymphotropic virus in Irish blood donors: Impact on future testing strategy
Authors: Williams Pádraig , O'Flaherty Niamh , Field Stephen , Waters Allison 
Published: July 2022

AbstractAimA risk‐based approach to the testing of blood donations for Human T‐Lymphotropic Virus (HTLV) should include an assessment of blood donation seroepidemiology. The objectives of the present study were to determine the proportion of HTLV positive units in Irish blood donations, and subsequently, to estimate the current risk of transfusion transmitted HTLV (TT‐HTLV).MethodsOver 3 million donations screened between 1996 and 2020, were included in the study (n = 3,666,253). Factors considered in the assessment of TT‐HTLV risk included: (I) HTLV seropositivity, (ii) probability of a leucodepletion failure, and (iii) the HTLV testing strategy.ResultsSix HTLV positive donations were detected throughout the study period, all of them in previously unscreened blood donors (0.000164%; n = 6/3,666,253), 3 of whom had donated prior to the introduction of HLTV antibody testing. On average 0.11% of manufactured blood components assessed, failed to satisfy the leucodepletion quality assurance criteria of less than 1 × 106 cells/unit. In using these values to model the risk of TT‐HTLV, it was shown that the combination of leucodepletion with either universal screening of all = donors, or selective testing of first‐time donors, a possible HTLV transfusion transmitted infection would be prevented every 468–3776 years.ConclusionsThis is the first report on the proportion of HTLV positive in Irish blood donations (1996–2020) and will be used to inform blood donation screening policy in Ireland. Evidence is provided for recommending a selective HTLV donor screening algorithm in Ireland that is accompanied by a robust framework for continued surveillance of leucodepletion failure rate.