bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients With Acute Coronary Syndromes Admitted to Contemporary Cardiac Intensive Care Units: Insights From the CCCTN Registry
Authors: Fagundes Antonio , Berg David D. , Park Jeong-Gun , Baird-Zars Vivian M. , Newby L. Kristin , Barsness Gregory W. , Miller P. Elliott , van Diepen Sean , Katz Jason N. , Phreaner Nicholas , Roswell Robert O. , Menon Venu , Daniels Lori B. , Morrow David A. , Bohula Erin A. ,   for the CCCTN Investigators
Published: July 2022

Background:
With the improvement in outcomes for acute coronary syndrome (ACS), the practice of routine admission to cardiac intensive care units (CICUs) is evolving. We aimed to describe the epidemiology of patients with ACS admitted to contemporary CICUs.

Methods:
Using the CCCTN (Critical Care Cardiology Trials Network) Registry for consecutive medical CICU admissions across 26 advanced CICUs in North America between 2017 and 2020, we identified patients with a primary diagnosis of ACS at CICU admission and compared patient characteristics, resource utilization, and outcomes to patients admitted with a non-ACS diagnosis and across sub-populations of patients with ACS, including by indication for CICU admission.

Results:

Of 10 118 CICU admissions, 29.4% (n=2978) were for a primary diagnosis of ACS, with significant interhospital variability (range, 13.4%–56.6%). Compared with patients admitted with a diagnosis other than ACS, patients with ACS had fewer comorbidities, lower acute severity of illness with less utilization of advanced CICU therapies (41.3% versus 66.1%,
P
<0.0001), and lower CICU mortality (5.4% versus 9.9%,
P
<0.0001). Monitoring alone, without another CICU indication at the time of admission, was the most frequent admission indication in patients with ACS (53.8%); less common indications in patients with ACS included respiratory insufficiency, shock, or the need for vasoactive therapy. Of patients with ACS admitted for monitoring alone, 94.8% did not subsequently require advanced intensive care unit therapies and had a low CICU length of stay (1.5 days [0.9–2.4] versus 2.6 [1.4–5.1],
P
<0.0001) and CICU mortality (0.6% versus 11.0%,
P
<0.0001), compared with patients with ACS with an admission indication beyond monitoring.

Conclusions:
In a registry of tertiary care CICUs, ACS represent ≈1/3 of all admissions with significant variability across hospitals. More than half of the ACS admissions to the CICU were for routine monitoring alone, with a low rate of complications and mortality. This observation highlights an opportunity for prospective studies to refine triage strategies for lower risk patients with ACS.
hapln1
Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration
Authors: Sun Jisheng , Peterson Elizabeth A. , Wang Annabel Z. , Ou Jianhong , Smith Kieko E. , Poss Kenneth D. , Wang Jinhu 
Published: July 2022

Background:
Certain nonmammalian species such as zebrafish have an elevated capacity for innate heart regeneration. Understanding how heart regeneration occurs in these contexts can help illuminate cellular and molecular events that can be targets for heart failure prevention or treatment. The epicardium, a mesothelial tissue layer that encompasses the heart, is a dynamic structure that is essential for cardiac regeneration in zebrafish. The extent to which different cell subpopulations or states facilitate heart regeneration requires research attention.

Methods:

To dissect epicardial cell states and associated proregenerative functions, we performed single-cell RNA sequencing and identified 7 epicardial cell clusters in adult zebrafish, 3 of which displayed enhanced cell numbers during regeneration. We identified paralogs of
hapln1
as factors associated with the extracellular matrix and largely expressed in cluster 1. We assessed
HAPLN1
expression in published single-cell RNA sequencing data sets from different stages and injury states of murine and human hearts, and we performed molecular genetics to determine the requirements for
hapln1
-expressing cells and functions of each
hapln1
paralog.

Results:

A particular cluster of epicardial cells had the strongest association with regeneration and was marked by expression of
hapln1a
and
hapln1b
. The
hapln1
paralogs are expressed in epicardial cells that enclose dedifferentiated and proliferating cardiomyocytes during regeneration. Induced genetic depletion of
hapln1
-expressing cells or genetic inactivation of
hapln1b
altered deposition of the key extracellular matrix component hyaluronic acid, disrupted cardiomyocyte proliferation, and inhibited heart regeneration. We also found that
hapln1
-expressing epicardial cells first emerge at the juvenile stage, when they associate with and are required for focused cardiomyocyte expansion events that direct maturation of the ventricular wall.

Conclusions:

Our findings identify a subset of epicardial cells that emerge in postembryonic zebrafish and sponsor regions of active cardiomyogenesis during cardiac growth and regeneration. We provide evidence that, as the heart achieves its mature structure, these cells facilitate hyaluronic acid deposition to support formation of the compact muscle layer of the ventricle. They are also required, along with the function of
hapln1b
paralog, in the production and organization of hyaluronic acid–containing matrix in cardiac injury sites, enabling normal cardiomyocyte proliferation and muscle regeneration.
Interventions in Adults With Repaired Coarctation of the Aorta
Authors: Meidell Blylod Viktor , Rinnström Daniel , Pennlert Johanna , Ostenfeld Ellen , Dellborg Mikael , Sörensson Peder , Christersson Christina , Thilén Ulf , Johansson Bengt 
Published: July 2022

Background
Coarctation of the aorta coexists with other cardiac anomalies and has long‐term complications, including recoarctation, which may require intervention after the primary coarctation repair. This study aims to clarify the prevalence of and risk factors for interventions related to the coarctation complex as well as late mortality in a large contemporary patient population.

Methods and Results
The Swedish National Register of Congenital Heart Disease was used, which comprised 683 adults with repaired coarctation of the aorta. Analysis was performed on freedom from intervention thereafter at the coarctation site, aortic valve, left ventricular outflow tract, or ascending aorta. One hundred ninety‐six (29%) patients had at least 1 of these interventions. Estimated freedom from either of these interventions was 60% after 50 years. The risk of undergoing such an intervention was higher among men (hazard ratio, 1.6 [95% CI, 1.2–2.2]). Estimated freedom from another intervention at the coarctation site was 75% after 50 years. In women, there was an increase in interventions at the coarctation site after 45 years. Patients who underwent one of the previously mentioned interventions after the primary coarctation repair had poorer left ventricular function. Eighteen patients (3%) died during follow‐up in the register. The standardized mortality ratio was 2.9 (95% CI, 1.7–4.3).

Conclusions
Interventions are common after coarctation repair. The risk for and time of interventions are affected by sex. Our results have implications for planning follow‐up and giving appropriate medical advice to the growing population of adults with repaired coarctation of the aorta.
Association Between Sleep Microstructure and Incident Hypertension in a Population‐Based Sample: The HypnoLaus Study
Authors: Berger Mathieu , Vakulin Andrew , Hirotsu Camila , Marchi Nicola Andrea , Solelhac Geoffroy , Bayon Virginie , Siclari Francesca , Haba‐Rubio José , Vaucher Julien , Vollenweider Peter , Marques‐Vidal Pedro , Lechat Bastien , Catcheside Peter G. , Eckert Danny J. , Adams Robert J. , Appleton Sarah , Heinzer Raphael 
Published: July 2022

Background
Poor sleep quality is associated with increased incident hypertension. However, few studies have investigated the impact of objective sleep structure parameters on hypertension. This study investigated the association between sleep macrostructural and microstructural parameters and incident hypertension in a middle‐ to older‐aged sample.

Methods and Results
Participants from the HypnoLaus population‐based cohort without hypertension at baseline were included. Participants had at‐home polysomnography at baseline, allowing assessment of sleep macrostructure (nonrapid eye movement sleep stages 1, 2, and 3; rapid eye movement sleep stages; and total sleep time) and microstructure including power spectral density of electroencephalogram in nonrapid eye movement sleep and spindles characteristics (density, duration, frequency, amplitude) in nonrapid eye movement sleep stage 2. Associations between sleep macrostructure and microstructure parameters at baseline and incident clinical hypertension over a mean follow‐up of 5.2 years were assessed with multiple‐adjusted logistic regression. A total of 1172 participants (42% men; age 55±10 years) were included. Of these, 198 (17%) developed hypertension. After adjustment for confounders, no sleep macrostructure features were associated with incident hypertension. However, low absolute delta and sigma power were significantly associated with incident hypertension where participants in the lowest quartile of delta and sigma had a 1.69‐fold (95% CI, 1.00–2.89) and 1.72‐fold (95% CI, 1.05–2.82) increased risk of incident hypertension, respectively, versus those in the highest quartile. Lower spindle density (odds ratio, 0.87; 95% CI, 0.76–0.99) and amplitude (odds ratio, 0.98; 95% CI, 0.95–1.00) were also associated with higher incident hypertension.

Conclusions
Sleep microstructure is associated with incident hypertension. Slow‐wave activity and sleep spindles, 2 hallmarks of objective sleep continuity and quality, were inversely and consistently associated with incident hypertension. This supports the protective role of sleep continuity in the development of hypertension.
Intensity of and Adherence to Lipid‐Lowering Therapy as Predictors of Major Adverse Cardiovascular Outcomes in Patients With Coronary Heart Disease
Authors: Mazhar Faizan , Hjemdahl Paul , Clase Catherine M. , Johnell Kristina , Jernberg Tomas , Sjölander Arvid , Carrero Juan Jesus 
Published: July 2022

Background
The effectiveness of lipid‐lowering therapy (LLT) is affected by both intensity and adherence. This study evaluated the associations of LLT intensity, adherence, and the combination of these 2 aspects of LLT management with the risk of major adverse cardiovascular events (MACE) in people with coronary heart disease.

Methods and Results
This is an observational study of all adults who suffered a myocardial infarction or had coronary revascularization during 2012 to 2018 and initiated LLT in Stockholm, Sweden. Study exposures were LLT adherence (proportion of days covered), LLT intensity (expected reduction of low‐density lipoprotein cholesterol), and the combined measure of adherence and intensity. At each LLT fill, adherence and intensity during the previous 12 months were calculated. The primary outcomes were MACE (nonfatal myocardial infarction or stroke and death); secondary outcomes were low‐density lipoprotein cholesterol goal attainment and individual components of MACE. We studied 20 490 patients aged 68±11 years, 75% men, mean follow‐up 2.6±1.1 years. Every 10% increase in 1‐year adherence, intensity, or adherence‐adjusted intensity was associated with a lower risk of MACE (hazard ratio [HR], 0.94 [95% CI, 0.93–0.96]; HR, 0.92 [95% CI, 0.88–0.96]; and HR, 0.91 [95% CI, 0.89–0.94], respectively) and higher odds of attaining low‐density lipoprotein cholesterol goals (odds ratio [OR],1.12 [95% CI, 1.10–1.15]; OR, 1.42 [95% CI, 1.34–1.51], and OR, 1.16 [95% CI, 1.19–1.24], respectively). Among patients with good adherence (≥80%), the risk of MACE was similar with low‐moderate and high‐intensity LLT despite differences in the low‐density lipoprotein cholesterol goal attainment with the treatment intensities. Discontinuation ≥1 year increased the risk markedly (HR,1.66 [95% CI, 1.23–2.22]).

Conclusions
In routine care, good adherence to LLT was associated with the greatest benefit for patients with coronary heart disease. Strategies that improve adherence and use of intensive therapies could substantially reduce cardiovascular risk.
Cat-Poo-Chino and Captive Wildlife: Tourist Perceptions of Balinese Kopi Luwak Agrotourism
Authors: Hooper Jes 
Published: July 2022

Abstract
Kopi luwak, known as the world’s most expensive coffee, is made from coffee beans that have been partially digested by the Asian palm civet (Paradoxurus hermaphroditus). This study aims to assess how tourists perceive the inclusion of captive civets within curated Balinese kopi luwak tours by analyzing 3,364 reviews of 25 sites housing live civets, posted to the tourist review platform, TripAdvisor, between October 2011 and March 2020. Overall, reviewers concerned with animal welfare were more likely to leave a negative review. Two emergent themes, encounters with caged animals and encounters with sleeping animals, are explored through a multispecies lens. Civet displays are discussed in relation to passive and true animal encounter, animal dignity, shared suffering, and cognitive dissonance. Although caged practices persist across sites, results also indicate new forms of concealed cruelty as civets are likely sedated to enable photographic souvenirs.
Odù Ifá in Transition: Contemplating Boundary Mechanisms in Discursive and Critical Appreciation of the Ifá Corpus
Authors: Anoba Ibrahim B. 
Published: July 2022

Abstract
Some Ifá priests and scholars have argued that noninitiates should not engage the Odù Ifá corpus. They suggest that such an undertaking could be spiritually dangerous and lead to the corruption of Ifá’s messages that its practitioners have established. This article demonstrates why the Odù Ifá corpus should be open to engagement by noninitiates who are familiar with Òrìṣà logics and the intricacies of the Yorùbá language in purely academic and nonspiritual spaces. Its method is premised on reviewing a particular category of literature on Yorùbá religion, and examining the corpus as an intellectual tradition within the web of cultural globalization.
Is the Church a Place of Solace or Frustration?
Authors: Sarfo Elizabeth Anokyewaa , Salifu Yendork Joana , Kpobi Lily 
Published: July 2022

Abstract
Religion is seen to have both positive and negative impacts on the individual and the society. The present study sought to investigate the impact of neo-prophetic Christianity on the members of neo-prophetic churches in Ghana. Eighty-six congregants of six neo-prophetic churches in Accra and Kumasi were sampled for this study. Methods used in the gathering of data included in-depth interviews, church observations, and focused group discussions. Results indicated that neo-prophetic Christianity has both positive and negative impacts on their members and the society in general. Some of the negative impacts included exploitation by church leaders, discrimination among church members and against other religions, and attribution of spiritual causes to illness and misfortune. The positive impacts of religion included the adoption of good personal values, provision of social support, the use of religious coping, as well as fostering hope and optimism. The implications of these findings are discussed.
From the Ruins of Empire
Authors: Rodriguez Lago José Ramón 
Published: July 2022

Abstract
After Spain lost its overseas territories, Spanish priests increased their presence in Africa. From an analysis of the bibliography and the press of the time as well as of the different documents issued by the nunciature of Madrid, the Sacred Congregation for the Propagation of the Faith and the Secretariat of State of the Vatican, it is possible to draw some significant conclusions about the evolution of Spanish missions in the Protectorate of Morocco and Spanish Guinea in the four decades which separate the so-called Disaster and the propagandistic myth of the Crusade represented by Francoists – and Africanists – during the Civil War.
Geographic variation in reproductive investment of seven populations of male Brown frog (Rana kukunoris), endemic to the eastern Tibetan Plateau
Authors: Yu Tong L. , Li Hai Y. , Chen Bo J. , Chen Peng Z. , Liu Xiang R. , Wang Yu 
Published: July 2022

Abstract
Life-history theory suggests that male anurans living in harsh and unpredictable environmental conditions (e.g., low temperature and/or high seasonality) should decrease reproductive investment because of short periods of activity and poor productivity. Although geographic variations in female life-history traits have been investigated intensively across a wide range of taxa, similar studies in males have been scarce. Here, we examined geographic variation in male testis mass of the brown frog (Rana kukunoris) across seven different altitudes on the eastern Tibetan plateau, and tested the hypothesis that relative size of testis mass should increase with increasing temperature and/or decreasing seasonality. In this study, we found male body condition, age and testis mass did not increase with temperature and temperature seasonality, which do not conform to our previous hypothesis, revealing that differences in temperature and temperature seasonality across populations could not drive the evolution of testis size. However, we found a positive correlation between testis mass and body condition or age when controlling for population and the effect of temperature and temperature seasonality, indicative of a condition-dependent expression of testis size. In addition, a correlation between testis mass and operational sex ratio was not significant, suggesting that male–male competition did not lead to increasing levels of sperm competition.
Wounded in Mission: Where in the World Are You from? Identity and Suffering in Discipleship and Witness
Authors: Velloso Ewell Rosalee 
Published: July 2022

Abstract
This essay examines the missionary calling and character of the people of God. The argument is made that the call to discipleship has significant implications for how Christians understand their identity. To be a disciple means to submit to a kingdom and a way of life that challenge the powers of this world and nationalistic understandings of identity. Discipleship also implies that following Christ entails bearing the wounds of a broken world as a testimony to the work of Christ. The key themes of discipleship, suffering and identity are examined through an analysis of biblical passages in the Gospel of John and some of Paul’s letters.
Missio Dei: Is There Any Common Ground?
Authors: Kjøde Rolf 
Published: July 2022

Abstract
Missio Dei has become a common and valued expression in most wings of the church. To what extent do we mean the same thing when we use this term? This article explores the understanding of the concept missio Dei in contemporary conciliar and evangelical contexts, with special emphasis on The Cape Town Commitment and Together towards Life. Although missio Dei has had a turbulent life with diverse definitions and connected interests in the relatively short time span of the term, there seems to be a growing convergence in its usage. This common ground is primarily connected to the change from an ecclesiocentric to a Trinitarian paradigm of mission and to understanding the kingdom of God as the goal of mission. There are, however, differences in the documents, and these are evident in the relative emphases they give to the centrality of Christ and the role of the Spirit.
What Does J.N. Farquhar Have to Say about Islam?
Authors: Singh David Emmanuel 
Published: July 2022

Abstract
John Nicol Farquhar was a Scottish missionary and orientalist, well-known even today for his ideas on fulfilment theology. Whereas Farquhar’s position on Hinduism vis-a-vis Christianity is still widely discussed, few are aware of what he wrote about Islam. This is because it is assumed that his view of Islam was no different from his view of other religious traditions. This article discusses the question of whether Islam was merely part of Farquhar’s broader conception of religious traditions in their Christ-ward journey. My provisional answer to this question is that while it is true that for Farquhar, Islam was part of the broader context of religions, he also viewed Islam as being distinct from other religious traditions, both mainstream and marginal. His view was that Islam stood alongside Christianity as an ally, as a catalyst of reform in religions, and as such, Islam was not just an object of Christ-ward transformation. In this article, I focus on three of Farquhar’s major writings containing material on Islam, which may not be very well-known to readers and commentators today. It is aimed at theological students and teachers, particularly those interested in the theology of religions and dialogue with Islam, so that they can build on what they already know, and shape their thinking about how to relate to Islam and Muslims as partners, not merely as objects in God’s mission.
A Declaration on the “Russian World” (Russkii Mir) Teaching
Authors: Gallaher Brandon , Kalaitzidis Pantelis 
Published: July 2022

Abstract
On March 13, 2022 (Sunday of Orthodoxy), Orthodox theologians and scholars from around the world issued an unprecedented theological declaration that draws on both the Barmen Declaration (1934) and the Synodikon of Orthodoxy, and is directed against the ethnophyletist and nationalist “Russian world” ideology that serves as the religious underpinning for Vladimir Putin’s invasion of Ukraine in February 2022. This ideology, fundamentalist in character, was developed by Patriarch Kirill (Gundiaev) of Moscow and both Putin and Patriarch Kirill repeatedly reference it in their active support of the Russian invasion. Having briefly outlined the Russian world ideology, the Declaration identifies the ideology’s main propositions, which are declared “heretical” from an Orthodox theological perspective. By contrast, the Orthodox scholars systematically outline affirmations drawn from Scripture and the Holy Tradition of Orthodox Christianity. Finally, the declaration calls all to be mindful of the theological principles outlined in their decisions in church politics.
Winds of Change in Australian Waters: The Offshore Electricity Infrastructure Act 2021
Authors: Goodman Camille 
Published: July 2022

Abstract
The untapped potential of offshore wind is vast, and will be critical in the global transition to renewable energy and carbon neutrality. Although Australia’s waters are home to enough wind energy to cover its entire electricity needs, the lack of a regulatory framework has prevented the establishment of an offshore wind industry. However, with the passage of the Offshore Electricity Infrastructure Act 2021, there are now significant opportunities for the offshore generation of renewable energy, as well as the transmission of electricity within—and beyond—Australian waters. Framed by consideration of the global and regional context, this paper provides a meaningful perspective on the potential for offshore wind energy in Australia, outlines the new regulatory framework which will enable it to be realised, and highlights key points of contact with contemporary issues of ocean law and policy.