bluuebunny/crossref_metadata_2025_split huggingface dataset:
Posterior circulation stroke due to intracranial artery disease in the Chinese population
Authors: Zhang Changqing , Li Zixiao , Liu Liping , Pu Yuehua , Zou Xinying , Yan Hongyi , Pan Yuesong , Zhao Xingquan , Wang Yilong , Wang Yongjun 
Published: August 2022

AbstractBackgroundLittle is known about the distribution of the intracranial arteries that are responsible for noncardiogenic posterior circulation stroke (PCS) in the Chinese population. Furthermore, few studies have compared the imaging manifestations and outcomes across PCS due to the disease of different intracranial arteries. Therefore, our aim was to demonstrate the distribution of the intracranial arteries that were responsible for noncardiogenic PCS and to compare the imaging manifestations and outcome across PCS due to the disease of different intracranial arteries.MethodsWe prospectively enrolled 690 patients from 22 Chinese centers with noncardiogenic PCS due to intracranial artery disease. Intracranial artery disease was classified as intracranial vertebral artery disease (IVAD) and intracranial nonvertebral artery disease (INVAD). Clinical‐radiologic patterns and outcomes were compared between IVAD and INVAD.ResultsINVAD was more frequent than IVAD. Compared to the INVAD group, the IVAD group more frequently had hypertension, coronary heart disease, multiple infarcts, border zone infarcts, territorial infarcts, small cortical infarcts, multilevel infarcts, multisector infarcts, and more often had severe stenosis of the responsible artery, more often presented with decreased alertness, gaze palsy, bilateral limb weakness, ataxia, dysphagia, diplopia, vertigo, and headache. In addition, the IVAD group had a higher National Institutes of Health stroke scale score and modified Rankin Scale score at discharge and more deaths and recurrent ischemic cerebrovascular disease within 1 year of onset. Multivariable Cox regression identified IVAD as an independent predictor of recurrent ischemic cerebrovascular disease.ConclusionsPCS due to INVAD was more common in the Chinese population. However, PCS due to IVAD had more serious clinical‐radiologic patterns and worse outcomes.
Carbon performance, financial performance and market value: The moderating effect of pay incentives
Authors: Adu Douglas A. , Flynn Antoinette , Grey Colette 
Published: August 2022

AbstractWe investigate the interrelationships among carbon performance, CEO Pay, executive compensation, financial performance and market value. Using data relating to non‐financial firms from UK FTSE 350 from 2009 to 2018, our findings are fourfold. First, our results suggest that actual carbon performance is negatively associated with financial performance and market value of firms. Second, we document that self‐reported carbon performance has no effect on financial performance. By contrast, we observe that self‐reported carbon reduction initiatives performance has positive impact on market value. Third, our results suggest that CEO Pay, and executive compensation have positive moderating effect on the association between self‐reported carbon performance and financial performance. In addition, we show that self‐reported carbon performance–market value nexus is positively moderated by CEO Pay and executive compensation. Fourth, we observe that CEO Pay, and executive compensation have no moderating impact on actual carbon performance–market value nexus. Our findings demonstrate that while firms appear to employ compensation incentives to symbolically enhance their self‐reported carbon performance, this does not result in actual carbon emission reduction. Our findings have key implications for policymakers.
Home‐based physical activity after treatment for esophageal cancer—A randomized controlled trial
Authors: Anandavadivelan Poorna , Malberg Kalle , Vikstrom Karin , Nielsen Sandra , Holdar Ulrika , Johar Asif , Lagergren Pernilla 
Published: August 2022

AbstractBackgroundThe treatment of most esophageal cancer patients includes chemo(radio)therapy and extensive surgery, causing physical decline with loss of muscles. This trial aimed to test the hypothesis that a tailored home‐based physical activity (PA) intervention improves muscle strength and mass in patients having undergone curative treatment for esophageal cancer.MethodsPatients operated for esophageal cancer 1 year earlier were included in a nationwide randomized controlled trial in Sweden in 2016–2020. The intervention group was randomized to a 12‐week home‐based exercise program, while the control group was encouraged to maintain routine daily PA. The primary outcomes were changes in maximal/average hand grip strength measured with hand grip dynamometer and lower extremity strength measured using 30‐second chair stand test and muscle mass measured using a portable bio‐impedance analysis monitor. Intention‐to‐treat analysis was used, and results were presented as mean differences (MDs) with 95% confidence intervals (CIs).ResultsAmong 161 randomized patients, 134 completed the study, 64 in the intervention group and 70 in the control group. Compared with the control group (MD 2.73; 95% CI 1.75–3.71), patients in the intervention group (MD 4.48; 95% CI 3.18–5.80) had statistically significantly (p = 0.03) improved lower extremity strength. No differences were seen for hand grip strength or muscle mass.ConclusionA home‐based PA intervention 1 year after surgery for esophageal cancer improves lower extremity muscle strength.
Dynamic leader role modeling for self‐organizing crowd evacuation simulation
Authors: Wu Hui , Wang Changbo , He Gaoqi 
Published: August 2022

AbstractThe role of the leader in the self‐organizing crowd has a significant influence on the crowd evacuation when an emergency occurs. However, current crowd evacuation models either ignore the leadership characteristics of pedestrians or predefine an invariable leader identity. This article clearly distinguishes leaders from followers in a crowd and evaluates the impact of the leader's role on crowd evacuation under dynamic situations. First, the leadership model of the pedestrian is built based on the classic OCEAN personality parameters. Social dominance tendency is measured for more credibility. Then, the dynamic leader role model (DLRM) is proposed to describe the relationship between leaders and followers, considering the interaction among pedestrians during the evacuation. Finally, a novel crowd simulation algorithm based on the above DLRM is presented using the extended social force model. Various experiments in several typical scenarios verified that our proposed simulation model has better realism.
Synthesis, Biological Evaluation, Migratory Inhibition and Docking Study of Indenopyrazolones as Potential Anticancer Agents
Authors: Hosseini Nasab Narges , Han Yohan , Hassan Shah Fahad , Vanjare Balasaheb D. , Ja Kim Song 
Published: August 2022

AbstractSome bioactive derivatives of indeno[1,2‐c]pyrazolones were synthesized through the reaction of phenylhydrazine, different aldehydes and indan‐1,2,3‐trione at room temperature in acetonitrile. Analytical and spectroscopic studies have confirmed the structural characteristics of the synthesized compounds. In addition, the target compounds were screened for thein‐vitroantiproliferative properties against the B16F10 melanoma cancer cell lines by the standard MTT assay. The effect on inflammatory marker cyclooxygenase 2 and matrix metalloproteinase 2, 9 was also checked to determine the anti‐inflammatory and anti‐cell migratory properties of these compounds. The final compounds were also tested for their tyrosinase inhibitory activity. Among all compounds, screened for anticancer activity, three compounds4e,4fand4hreduced the cell proliferation significantly comparable to that of the positive standard drug erlotinib (IC50=418.9±1.54 μM) with IC50values ranging from 20.72–29.35 μM. The compounds4c–4hdecreased the COX‐2 expression whereas the MMP 2, 9 expressions were significantly reduced by4a,4band4h. This was confirmed by molecular docking studies, as4e,4fand4hdisplayed good interactions with the active site of BRAF protein. The compounds4b,4fand4hexhibited moderate tyrosinase inhibition effect as compared to α‐MSH. Collectively, compound4hcan be considered as a candidate for further optimization in the development of anticancer therapies based on the results of biological investigations in this study.
Magnetic resonance imaging image analysis of the therapeutic effect and neuroprotective effect of deep brain stimulation in Parkinson's disease based on a deep learning algorithm
Authors: Zhang Jianzhong , Zhou Chaoyang , Xiao Xiang , Chen Weihua , Jiang Yi , Zhu Ronglan , Xin Tao 
Published: August 2022

AbstractIn order to study the therapeutic neuroprotective effect of deep brain stimulation (DBS) in Parkinson's disease (PD), based on the deep learning algorithm, this study combines with magnetic resonance imaging (MRI) image analysis technology to study the clinical efficacy of DBS in the surgical treatment of PD and the neuroprotective and neurological recovery effects after surgery. Establish a deep learning algorithm model based on MRI image analysis technology, comparison of UPDRS motor status assessment and the improvement of daily life ability before and after DBS surgery, evaluate the accuracy rate and the detection speed of the model. The models constructed in this study have an accuracy rate of more than 90% in the PD detection test, and the detection speed of the algorithm model under the condition of big data is between 60 and 200 ms. DBS significantly improve a series of clinical symptoms in patients with PD. The deep learning algorithm model based on MRI image analysis technology in this paper has a certain effect. DBS operation can improve the symptoms of PD, and has the effect of neuroprotection and neurological recovery.
Comparison of flexible endoscopy and magnetic resonance imaging in determining the tumor height in rectal cancer
Authors: Basendowah Mohammed H. , Ezzat Mohammed A. , Khayyat Aseel H. , Alamri Eyad Saleh A. , Madani Turki A. , Alzahrani Anas H. , Bokhary Rana Y. , Badeeb Arwa O. , Hijazi Hussam A. 
Published: August 2022

AbstractBackgroundSeveral modalities are available for the diagnosis of rectal cancer, including conventional gold standard rigid endoscopy and recent flexible endoscopy and magnetic resonance imaging (MRI). Each modality affects the management of these patients.AimTo compare the accuracy of flexible endoscopy and MRI in the measurement of tumor height in patients with rectal cancer.Methods and ResultsThis study included 174 patients with rectal cancer who underwent flexible endoscopy and MRI for the measurement of tumor height. Data on patient demographics, comorbidities, treatment, and histopathology were identified and collected. We evaluate intraclass correlation coefficient (ICC) and Bland–Altman plot to test the agreement between the measurements. ICC were excellent with an ICC of 89% (95%CI 48%–99%). The mean ± standard deviation of the distance from the anal verge to the distal part of the tumor was 7.73 ± .47 for flexible endoscopy and 6.21 ± 0.39 for MRI, with mean difference of 1.52 (p ˂ .001). The accordance between the two modalities was not affected by sex, age, body mass index, histopathology, or metastasis.ConclusionExcellent agreement between flexible endoscopy and MRI was noted, and no factor was found to affect such concordance.
PKPD Modeling and Simulations to Support Biosimilar Development of Biphasic Insulin Aspart 30
Authors: Petrov Aleksandr V. , Zinnatulina Bella R. , Drai Roman V. , Karonova Tatiana L. , Koksharova Ekaterina O. , Dorotenko Artem R. , Makarenko Igor E. 
Published: August 2022

AbstractThis paper presents an analysis of data from a comparative study of biosimilarity in terms of pharmacokinetics and
pharmacodynamics in healthy volunteers using a hyperinsulinemic euglycemic clamp for reference and test biphasic
insulin aspart 30 (BIAsp 30). As a result of the study, one of the secondary pharmacodynamic (PD) endpoints did not satisfy the classical criterion of 80%–125% (the lower limit for PD parameter area under the glucose infusion rate–time curve [] turned out to be 79.5%). The main hypothesis explaining this result is that the sample size is insufficient to conduct a PD test with 90% statistical power, since the sample size has been calculated based on the coefficient of variation (CV) of pharmacokinetic (PK) parameters. To test this hypothesis, population PKPD (popPKPD) modeling and subsequent simulations of the required number of PD profiles were used. Two popPKPD models were constructed (a one‐compartment double simultaneous absorption model for PK and an effect compartment Emax model for PD) to describe the PKPD data of reference and test insulins. As a result, using real data along with model‐based simulation data, a biosimilarity test for PD was performed, and the lower limit for became 82.6%, while the CV decreased from 31.7% to 24.1%. Thus, popPKPD modeling and simulations have been shown to be effective in interpreting and supporting the results of clinical biosimilarity trials.
Personality characteristics in specialist and generalist intimate partner violence perpetrators
Authors: Teva Inmaculada , Marín‐Morales Agar , Bueso‐Izquierdo Natalia , Pérez‐García Miguel , Hidalgo‐Ruzzante Natalia 
Published: August 2022

AbstractIntimate partner violence (IPV) is one of the most common types of violence against women. Although personality disorders have been associated with IPV, perpetration research regarding personality according to the classification specialist/generalist IPV perpetrators is scarce. The general aim of this study was to describe personality in a large sample of IPV Spanish male perpetrators considering their classification (specialist vs. generalist). Participants were 1093 men convicted of IPV crimes whose ages ranged from 18 to 76 years old (M = 40.15; SD = 10.32). Of them, 554 men were classified as specialist perpetrators and 539 men were classified as generalist perpetrators. Participants completed questionnaires regarding sociodemographic and violence aspects as well as the Spanish version of the Millon Clinical Multiaxial Inventory III. Generalist perpetrators showed higher means in nearly all the personality disorders scales compared to specialist perpetrators. Prevalence rates in the majority of personality disorders were lower than 5%. Higher scores on the avoidant, histrionic, and self‐defeating scales and lower scores on the aggressive, borderline, and drug dependence scales were related to being a specialist perpetrator. This study contributes to a better understanding of personality among generalist and specialist perpetrators.
Patient personality dimensions, relational patterns and therapeutic alliance in clinical practice: An empirical investigation
Authors: Tanzilli Annalisa , Boldrini Tommaso , Carone Nicola , Gualco Ivan , Lingiardi Vittorio , Williams Riccardo 
Published: August 2022

AbstractIntroductionTransference (meant in this context, as the patient relational patterns expressed towards the clinician) and therapeutic alliance play a crucial role in the treatment of personality pathology. To date, no empirical study examined the association between these two dimensions of the clinical relationship and patients' personality maladaptive traits in psychotherapy.MethodsA national sample of therapists (N = 100) of different theoretical orientations assessed dysfunctional personality features of a patient in their care using a comprehensive and empirically grounded dimensional diagnostic approach from the Shedler–Westen Assessment Procedure‐200 (SWAP‐200). Moreover, they filled in the Psychotherapy Relationship Questionnaire (PRQ) to identify interpersonal patterns expressed early in treatment by the patients and the Working Alliance Inventory (WAI‐T) to evaluate quality of therapeutic alliance.ResultsOverall, the most severe and maladaptive dimensions of patients' personality were associated with more negative clinician–patient dynamics and poorer levels of therapeutic alliance in statistically significant and clinically relevant ways. Notably, the hostile transference was predicted by both SWAP Hostility and Psychopathy, whereas the SWAP Narcissism was the strongest predictor of the special/entitled transference. The latter was also predicted by SWAP Emotional Dysregulation; conversely, the SWAP Dysphoria was the most robust predictor of anxious/preoccupied pattern. The SWAP Schizoid Orientation and Psychopathy predicted avoidant/dismissing attachment pattern; moreover, they were strongly and negatively related to the SWAP Psychological Health that was the best predictor of positive transference and alliance.ConclusionsFindings support that therapists' careful understanding of patients' interpersonal ways during early treatment stages may meaningfully inform diagnostic and therapeutic processes.
Measuring Pattern Separation in Hippocampus by in Situ Hybridization
Authors: Eom Kisang , Lee Hyoung‐Ro 
Published: August 2022

AbstractDistinguishing different contexts is thought to involve a form of pattern separation that minimizes overlap between neural ensembles representing similar experiences. Theoretical models suggest that the dentate gyrus (DG) segregates cortical input patterns before relaying its discriminated output patterns to the CA3 hippocampal field. This suggests that the evaluation of neural ensembles in DG and CA3 could be an important means to investigate the process of pattern separation. In the past, measurement of entorhinal cortex (EC), DG, and CA3 ensembles was largely dependent upon in vivo electrophysiological recording, which is technically difficult. This protocol provides a method to instead measure pattern separation by a molecular method that provides direct spatial resolution at the cellular level. © 2022 Wiley Periodicals LLC.Basic Protocol: Measuring pattern separation by molecular methods
One‐sided 10T static‐random access memory cell for energy‐efficient and noise‐immune internet of things applications
Authors: Darabi Abdolreza , Salehi Mohammad Reza , Abiri Ebrahim 
Published: August 2022

AbstractThis paper presents a one‐sided 10‐transistors static‐random access memory (SRAM) cell appropriate for the internet of things (IoT) applications in which energy‐efficient SRAM cells are necessary to raise the battery lifetime. The bit‐cell core of the proposed SRAM cell is composed of two inverters with different structures based on the gate‐wrap‐around (GWA) carbon nanotube (CNT)‐gate‐diffusion input (GDI) technique and only one‐bit line to perform both read and write operations to minimize active power consumption. The proposed bit‐cell uses a transmission gate network and write‐assist schemes to significantly improve the write‐ability and stack read‐decoupling technique to enhance hold‐/read‐stability. Moreover, a memory mini‐array has been implemented using the proposed cell along with all the principal circuitries. Extensive Monte Carlo (MC) simulations show that write/hold/read static noise margins (SNMs) are improved by about 1.252, 1.196, and 1.152 times, respectively. Also, the results of evaluating the write‐ and read‐yield parameters for the proposed SRAM bit‐cell are about 22% and 13% better than counterpart bit‐cell designs, respectively. In addition, the bit error rate (BER) and energy dissipation parameters for the proposed memory cell are almost 61% and seven times higher than the studied SRAM bit‐cell in the same simulation process. Finally, to evaluate the effectiveness of the proposed SRAM bit‐cell in the real‐world application, a memory array architecture with an online (or off‐chip) adaptive power supply voltage based on a hardware algorithm for storing digital images at a minimum energy dissipation is proposed. Our simulation results emphasize that the proposed memory array can be a good candidate for energy‐efficient and noise‐immunity IoT platforms.
Comprehensive molecular analysis of immortalization hallmarks in thyroid cancer reveals new prognostic markers
Authors: Montero‐Conde Cristina , Leandro‐García Luis Javier , Martínez‐Montes Ángel M. , Martínez Paula , Moya Francisco J. , Letón Rocío , Gil Eduardo , Martínez‐Puente Natalia , Guadalix Sonsoles , Currás‐Freixes Maria , García‐Tobar Laura , Zafon Carles , Jordà Mireia , Riesco‐Eizaguirre Garcilaso , González‐García Patricia , Monteagudo María , Torres‐Pérez Rafael , Mancikova Veronika , Ruiz‐Llorente Sergio , Pérez‐Martínez Manuel , Pita Guillermo , Galofré Juan Carlos , Gonzalez‐Neira Anna , Cascón Alberto , Rodríguez‐Antona Cristina , Megías Diego , Blasco María A. , Caleiras Eduardo , Rodríguez‐Perales Sandra , Robledo Mercedes 
Published: August 2022

BackgroundComprehensive molecular studies on tumours are needed to delineate immortalization process steps and identify sensitive prognostic biomarkers in thyroid cancer.Methods and ResultsIn this study, we extensively characterize telomere‐related alterations in a series of 106 thyroid tumours with heterogeneous clinical outcomes. Using a custom‐designed RNA‐seq panel, we identified five telomerase holoenzyme‐complex genes upregulated in clinically aggressive tumours compared to tumours from long‐term disease‐free patients, being TERT and TERC denoted as independent prognostic markers by multivariate regression model analysis. Characterization of alterations related to TERT re‐expression revealed that promoter mutations, methylation and/or copy gains exclusively co‐occurred in clinically aggressive tumours. Quantitative‐FISH (fluorescence in situ hybridization) analysis of telomere lengths showed a significant shortening in these carcinomas, which matched with a high proliferative rate measured by Ki‐67 immunohistochemistry. RNA‐seq data analysis indicated that short‐telomere tumours exhibit an increased transcriptional activity in the 5‐Mb‐subtelomeric regions, site of several telomerase‐complex genes. Gene upregulation enrichment was significant for specific chromosome‐ends such as the 5p, where TERT is located. Co‐FISH analysis of 5p‐end and TERT loci showed a more relaxed chromatin configuration in short telomere‐length tumours compared to normal telomere‐length tumours.ConclusionsOverall, our findings support that telomere shortening leads to a 5p subtelomeric region reorganization, facilitating the transcription and accumulation of alterations at TERT‐locus.
Vitiligo: A black patch on white skin is a blessing—but a white patch on black skin is a curse
Authors: Ghia Deepti , Mysore Venkataram 
Published: August 2022

AbstractBackgroundVitiligo is one of the most common skin disorders of possible autoimmune etiology, causing serious cosmetic, psychological, financial, social problems, and affecting the quality of life. There is a lack of recognition of the sufferings of these patients as it is neither visible nor obvious in the fair‐skinned population. Treatment modalities too are varied and there is still a lack of expertise among physicians treating the disease.ObjectiveTo highlight the magnitude of the suffering due to Vitiligo and the need for its recognition for greater efforts by governmental and nongovernmental agencies to address the issues surrounding this disease.ConclusionVitiligo affects the quality of life by its chronicity, visibility, and relapsing nature. The treatments are often expensive, and not easily accessible. There is a need for greater research to develop more effective modalities through the involvement of international organizations and better coordination with the private sector and patient groups to make information and treatments available, accessible, and economical for all patients.