bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compartmental analysis of three-dimensional choroidal vascularity and thickness of myopic eyes in young adults using SS-OCTA
Authors: Luo Huan , Sun Jinfu , Chen Lan , Ke Dandan , Zhong Zheng , Cheng Xi , Yu Huimin , Sun Xufang 
Published: September 2022

Purpose: We aimed to investigate the change of three-dimensional (3D) choroidal thickness (ChT), choroidal vessel volume (CVV), and choroidal vessel index (CVI) in young myopic adults using swept-source optical coherence tomography angiography (SS-OCTA) and compare the difference of these indicators in different quadrants of the macula and optic disc.Methods: A total of 248 eye samples from 135 participants were used in this cross-sectional study. Each participant underwent detailed history taking and ocular examinations. Based on axial length (AL), patients were divided into the emmetropia (EM) group, mild-myopia (MIM) group, moderate-myopia (MOM) group, and high-myopia (HM) group. 6 mm × 6 mm (1,024 × 1024 B-scans) SS-OCTA scans were performed centered on the fovea and optic disc. 3D ChT, CVV, and CVI were measured based on a built-in deep learning algorithm. Differences in ChT, CVV, and CVI were analyzed in different regions and different myopic groups.Results: Significant reduction in the global CVV were found in the HM group (1.930 ± 0.865) in comparison with the EM (3.486 ± 0.992), MIM (3.238 ± 1.033), and MOM (2.589 ± 1.083) groups (p &lt; 0.001). The global CVI was also lower in the HM group (0.258 ± 0.061) than in the EM (0.320 ± 0.055), MIM (0.320 ± 0.051), and MOM (0.286 ± 0.066) groups (p &lt; 0.001). The ChT was thinner in eyes with HM (242.753 ± 65.641) than in eyes with EM (377.532 ± 80.593), MIM (348.367 ± 78.191), or MOM (300.197 ± 87.175) (p &lt; 0.001). Compartmental analysis revealed that ChT, CVV, and CVI in the nasal quadrant of the macula and temporal and inferior quadrants of the optic disc were much lower than those in other quadrants (p &lt; 0.05). Correlation analyses found that ChT, CVV, and CVI were negatively correlated with AL and spherical equivalence.Conclusion: 3D ChT, CVV, and CVI gradually decreased as the degree of myopia increased. The changes were more dramatic on the nasal side of the macula and the temporal and inferior sides of the optic disc. These findings demonstrated the 3D choroidal change and highlighted the papillo-macular bundle as a sensitive region in myopic development.
Can resilience promote calling among Chinese nurses in intensive care units during the COVID-19 pandemic? The mediating role of thriving at work and moderating role of ethical leadership
Authors: Sun Tao , Zhang Shu-e , Yin Hong-yan , Li Qing-lin , Li Ye , Li Li , Gao Yu-fang , Huang Xian-hong , Liu Bei 
Published: September 2022

BackgroundNurses working in the intensive care unit (ICU) clung tenaciously to their job during the COVID-19 pandemic in spite of enduring stressed psychological and physical effects as a result of providing nursing care for the infected patients, which indicates that they possessed a high degree of professionalism and career calling. The aim of this study was to explain the associations between resilience, thriving at work, and ethical leadership influencing the calling of ICU nurses.MethodsFrom December 2020 to January 2021 during the COVID-19 pandemic, a cross-sectional survey of 15 provinces in China was conducted using an online questionnaire. A total of 340 ICU nurses (effective response rate: 64.89%) completed sufficient responses to be used in the study. Sociodemographic factors, job demographic factors, resilience, calling, thriving at work, and ethical leadership were assessed using the questionnaire. General linear modeling (GLM), hierarchical linear regression (HLR) analysis, and generalized additive model (GAM) were performed to examine all the considered research hypotheses.ResultsResilience was positively and significantly associated with calling. Moreover, thriving at work partially mediated the relationship between resilience and calling. The indirect effect of resilience on calling was 0.204 (p &lt; 0.0001), and the direct effect of resilience on calling through thriving at work was 0.215 (p &lt; 0.0001). The total effect of resilience on calling was 0.419 (p &lt; 0.0001). In addition, ethical leadership played a moderating role in the relationship between resilience and calling (β = 0.16, p &lt; 0.05).ConclusionGreater resilience can positively predict increased calling among Chinese ICU nurses during the COVID-19 pandemic. Moreover, thriving at work is a mechanism that partly transmits the positive effects of resilience on calling. Overall, nurses possessing greater resilience tend to maintain thriving at work in the face of such adversity, further resulting in subsequently increased calling. Besides, findings suggest that there is stronger influence of resilience on calling among nurses working in an organization managed by an ethical leader. The current findings may offer two insights for nursing practitioners and policymakers in the postpandemic world. First, resilience training and intervention are necessary to foster nurses' sense of thriving at work in the nursing industry, further promoting career calling. Second, better training and effort on the development of ethical leadership for leaders in nursing practice are essential to encourage followers to engage in social learning of ethical behaviors and abiding by normatively appropriate conduct, further enacting prosocial values and expressing moral emotions.
Efficacy of digital technologies aimed at enhancing emotion regulation skills: Literature review
Authors: Jadhakhan Ferozkhan , Blake Holly , Hett Danielle , Marwaha Steven 
Published: September 2022

BackgroundThe impact of emotion regulation (ER) interventions on mental health and wellbeing has been extensively documented in the literature, although only recently have digital technologies been incorporated in intervention design. The aim of this review is to explore available published literature relating to the efficacy, barriers and facilitators of digital technologies in enhancing emotion/mood regulation skills.MethodsA review of the literature was performed to explore the effectiveness of digital technology in enhancing ER skills. MEDLINE, CINAHL, PsycINFO and Web of Science databases were searched from inception to 31st August 2020. In addition, the first 10 pages of Google Scholar were examined for relevant articles. The following MeSH term and key words were used to identify relevant articles: “emotion regulation OR mood regulation” AND “intervention OR treatment OR program$ OR therap$” AND “digital technologies OR web-based OR mobile application OR App.” Reference lists of retrieved papers were hand searched to identify additional publications. Findings were summarized narratively.ResultsTitles and abstracts were reviewed by one reviewer in two phases, and confirmed by a second reviewer; discrepancies were resolved through discussion. First, the retrieved titles and abstracts were reviewed to identify relevant studies. Full texts of retrieved studies were then read to determine eligibility. The search resulted in 209 studies of which 191 citations were identified as potentially meeting the inclusion criteria. After reviewing the title and abstract of the 191 papers, 33 studies were identified as potentially meeting the inclusion criteria. Following full-text review, 10 studies met the inclusion criteria. Findings indicated the potential effectiveness of online, text-messaging, and smartphone interventions for enhancing ER skills.ConclusionThere is encouraging evidence that digital technologies may be beneficial for enhancing ER skills and providing personalized care remotely. Digital technologies, particularly the use of smartphones, were instrumental in facilitating assessments and delivering online self-help interventions such as cognitive behavioral therapy. Continued research is required to rigorously evaluate the effectiveness of digital technologies in ER skills and carefully consider risks/benefits while determining how emerging technologies might support the scale-up of ER skills and mental health treatment.
The efficacy and safety of Jin's three-needle therapy vs. placebo acupuncture on anxiety symptoms in patients with post-stroke anxiety: A study protocol for a randomized controlled trial
Authors: Li Meichen , Wang Yuting , Li Keyi , Xu Xiaoyan , Zhuang Lixing 
Published: September 2022

BackgroundA large number of clinical RCTs have verified that Jin's three-needle therapy (JTNT) has a great contribution to promoting the function of paralyzed limbs and relieving anxiety disorders for patients with post-stroke anxiety (PSA). However, there is still a lack of sham needle control, and its placebo effect cannot be ruled out. This study firstly verifies the real effectiveness of JTNT. Besides, the changes in serum indexes on the hypothalamic-pituitary-adrenal axis (HPA axis) are observed dynamically by the Enzyme-Linked ImmunoSorbent Assay (ELISA). The activation of different brain regions by JTNT is recorded using resting functional magnetic resonance imaging (rs-fMRI). Therefore, we can provide more practical and powerful evidence-based medical evidence for clinical decisions.MethodThis is a 16 week parallel, single-blind, random, controlled trial, including baseline, 4 weeks of treatment, and 12 weeks of follow-up. A total of 114 participants will be randomly divided into three groups in the proportion of 1:1:1. Participants will receive Jin's three-needle therapy in the active acupuncture group and accept sham needle treatment in the sham acupuncture group. In the waitlist control group, patients will not receive any acupuncture treatment. Outcomes cover three types of indicators, including scale indicators, serum indicators, and imaging indicators. The primary outcome is the change in the performance of anxiety symptoms, which is estimated by the 14-item Hamilton Anxiety Rating Scale (HAMA-14) and the 7-item Generalized Anxiety Disorder scale (GAD-7). Secondary outcomes are physical recovery and daily quality of life, which are evaluated by the National Institute of Health stroke scale (NIHSS) and the Modified Barthel Index Score (MBI Scale). Therefore, the assessment of the scale is carried out at baseline, 2nd, 4th, 8, 12, and 16 weeks. Adrenocorticotropin and cortisol will be quantitatively detected by ELISA at baseline and 4 weeks after treatment. In addition, regional homogeneity analysis (ReHo) will be used to record the activity of brain regions at baseline and 4 weeks after intervention.DiscussionThe study aims to provide high-quality clinical evidence on the effectiveness and safety of JTNT for patients with PSA. In addition, this trial explores a possible mechanism of JTNT for patients with PSA.Clinical trial registrationChinese Clinical Trial Registry, identifier [ChiCTR2200058992].
Impulsivity trait mediates the relationship between white matter integrity of prefrontal–striatal circuits and the severity of dependence in alcoholism
Authors: Wu Fei , Dong Ping , Wu Guowei , Deng Jiahui , Ni Zhaojun , Gao Xuejiao , Li Peng , Li Bing , Yuan Junliang , Sun Hongqiang 
Published: September 2022

BackgroundAlcohol dependence (AD) remains one of the major public health concerns. Impulsivity plays a central role in the transfer from recreational alcohol use to dependence and relapse. White matter dysfunction has been implicated in alcohol addiction behaviors and impulsivity. However, little is known about the role of systematic striatal structural connections underlying the mechanism of impulsive traits in AD.MethodsIn our study, we used seed-based classification by probabilistic tractography with five target masks of striatal circuits to explore the differences in white matter integrity (fractional anisotropy, FA) in AD male patients (N = 51) and healthy controls (N = 27). We mainly explored the correlation between FA of the striatal circuits and impulsive traits (Barratt Impulsiveness Scale, BIS-11), and the mediation role of impulsivity in white matter integrity and the severity of alcohol dependence.ResultsCompared with healthy controls, AD showed much lower FA in the left and right striatum–supplementary motor area (SMA) and left striatum–amygdala. We also found the decreased FA of right striatum-vlPFC was correlated with higher impulsivity. Besides, the relationship between reduced FA of right striatum-vlPFC and severity of dependence could be mediated by impulsivity.ConclusionIn our study, we found disrupted white matter integrity in systematic striatal circuits in AD and the decreased FA of right striatum-vlPFC was correlated with higher impulsivity in AD. Our main findings provide evidence for reduced white matter integrity of systematic striatal circuits and the underlying mechanisms of impulsivity in male AD individuals.
Economic evaluation of first-line nivolumab plus cabozantinib for advanced renal cell carcinoma in China
Authors: Wang Hao , Wang Ye , Li Li , Zhou Han , Lili Shang , Li Liao , Yike Shen , Aixia Ma 
Published: September 2022

BackgroundIn the Checkmate9ER trial, first-line treatment with nivolumab combined with cabozantinib (NI + CA) has shown efficacy for advanced renal cell carcinoma. This study aims to evaluate the impact of the health and economic outcomes of NI + CA in China.MethodsClinical efficacy data were derived from pivotal phase III CheckMate 9ER trial. A three-state partitioned survival model was established based on disease progression. Progression-free survival and overall survival of NI + CA vs. sunitinib were fitted with log-logistic and log-normal distributions, respectively. Mixture cure, non-mixture cure, and Royston/Parmar spline models were used to evaluate model robustness. The results derived the computational cost from the Chinese healthcare system perspective. The primary outcomes were quality-adjusted life-years (QALYs), total cost in US dollars, as well as incremental cost-effectiveness ratios (ICERs) at the willingness-to-pay threshold in China. One-way and probabilistic sensitivity analysis were also used to assess the robustness of the model.ResultsIn the base-case analysis result, 0.86 additional QALYs could be obtained in the NI+CA (3.84 QALYs) versus the sunitinib strategy (2.97 QALYs). The ICER of NI+CA compared with the sunitinib strategy was US$292,945 per QALY. The ICER value in the NI+CA strategy was higher than the Chinese willingness-to-pay threshold of US$38,024 per QALY. Although NI+CA can improve long-term patient survival significantly over sunitinib in the treatment of advanced renal cell carcinoma, it is unlikely to be cost-effective due to high cost. The results of the one-way sensitivity analysis showed that drug cost, health utility value at the stage of disease progression, and subsequent treatment proportion had a greater impact on the stability of ICER values.ConclusionsNivolumab combined with cabozantinib can prolong the life of patients with advanced renal cell carcinoma and improve their quality of life, but there is a corresponding increase in medical cost. The NI + CA strategy is unlikely to be considered cost-effective in the treatment of advanced RCC from the perspective of Chinese healthcare system.
Mapping knowledge structure and themes trends in unilateral biportal endoscopic spine surgery: A bibliometric analysis
Authors: Zhu Ming-Tao , Li Kunrong , Hu Bao-Shan , Chen Chien-Min , Lin Guang-Xun 
Published: September 2022

BackgroundThe numerous benefits of unilateral biportal endoscopic (UBE) spine surgery have attracted the attention of many researchers, and a considerable number of relevant clinical studies have been published. However, global research trends in the field of UBE have received little attention. The purpose of this study was to apply bibliometric method to analyze the UBE-related publications to obtain an overview of the research trends in the field of UBE, as well as research hotspots and trends.MethodsWeb of Science database was searched for articles published until January 31, 2022. CiteSpace was used to analyze the data, which provided graphical knowledge maps. The following factors were applied to all literature: number of publications, distribution, h-index, institutions, journals, authors, and keywords.ResultsSeventy-three articles were identified. Since 2019, there has been a significant increase in the number of UBE-related publications. The country with the largest number of articles was South Korea (72.6%), followed by China (9.6%), Japan (4.1%), and Egypt (4.1%). South Korea had the highest h-index (16), followed by China (2), Japan (1), and Egypt (1). Leon Wiltse Memorial Hospital was the organization that produced the most papers (12 publications). Heo DH was the most productive author (16 papers) and was the most cited author (35 times). World Neurosurgery published the most papers on UBE (23.3%). The main research hotspots were spinal diseases, decompression, complications, learning curve, and interbody fusion. In addition, the recent concerns were “learning curve,” “interbody fusion,” “management,” and “dural tear.”ConclusionsThe quantity of publications on UBE research will increase, and South Korea being the major contributor and most prominent country in this field. The findings of our study will provide researchers with practical information on the field of UBE, and identification of mainstream research directions and recent hotspots.
Case report: Type I diastematomyelia with breast abnormalities and clubfoot
Authors: Hao Shenshen , Yue Zenan , Yu Xin , Gao Zhenfu , Li Hongke , Liu Shuai , Dong Shengli 
Published: September 2022

BackgroundDiastematomyelia is a rare congenital spinal cord malformation, classified as type I or type II, with over half of the cases considered type I. However, type I diastematomyelia with breast abnormality and clubfoot is extremely rare in clinical practice.Case presentationWe admitted an 18-year-old female patient with type I diastematomyelia with breast abnormalities and clubfoot. She was underwent surgical treatment. After the surgical removal of the pressure-causing bone spur, the weakness of the right lower limb was significantly relieved. During the 22-month follow-up, there was no complication and no recurrence.ConclusionSurgical removal of the pressure-causing bone spur can relieve symptoms in the lower limbs. However, further research is warranted to explore the breast abnormalities in patients with diastematomyelia.
1U-Sized Deployable Space Manipulator for Future On-Orbit Servicing, Assembly, and Manufacturing
Authors: Liu Jinguo , Zhao Pengyuan , Chen Keli , Zhang Xin , Zhang Xiang 
Published: September 2022

Miniaturized, multifunctional, and economical on-orbit service satellites have been increasingly used with the continuous increase of space exploration missions. In this paper, an innovative deployable manipulator is designed, named Cubot, which can be stowed in 1 U-sized (

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) space. With CubeSat as the carrier, the deployable Cubot aims to achieve a variety of on-orbit operation tasks including space debris removal and space station on-orbit maintenance, for future on-orbit servicing, assembly, and manufacturing (OSAM). A kinematics modeling method of a space manipulator with passive joints is proposed, and the motion equation of the manipulator is derived. Considered the elastic potential energy stored in the passive joint during deployment, the momentum change of Cubot is simulated and analyzed. As the main forced element, the end effector is analyzed using FEA. Dynamic stress response with respect to the force distribution and the clamping angle is analyzed to evaluate mechanical performances of the end-effector component. Deployment tests are conducted to verify the feasibility of Cubot based on a principled prototype, which aims to provide engineering and practical experience for the development of this field.
From Teachers’ Innovative Practices to Students’ Co-Creation: A Glimpse of the Project “Link Me Up – 1000 Ideias”
Authors: Fernandes Rosina , Amante Susana 
Published: September 2022

Higher Education Institutions are, more than ever, open to innovative practices, and nowadays the triple helix of University, Industry and Government is taking place through the implementation of projects such as “Link Me Up – 1000 Ideias”. This project, funded by COMPETE, was created as a network bringing together thirteen Portuguese Polytechnic Institutes to promote entrepreneurship among students, called talents, in academia. In a multidisciplinary approach, a co-creation team of 4-6 students, working together with organisation partners and using teacher’s innovative practices, explore a future-oriented challenge in order to design solutions, ideas and future scenarios, in an 8-week process that aims to empower students to create their own innovative companies or projects and to help them to be prepared for the transition to the world of work, developing soft skills that are required in our competitive society. This project is linked to another, entitled “Learning based on co-creation processes,” funded by POCH, in a partnership with DEMOLA Global, which provides teachers (in this process, they become facilitators) with innovative methodologies that are then operationalised when implementing co-creation challenges. In this study, we aim at presenting the “Link Me Up” project from the point of view of students from the Polytechnic Institute of Viseu and local organisations, by a) reflecting upon the questionnaires applied to students and companies to assess their degree of satisfaction with their participation in the project, identifying key areas enhanced by the experience. Additionally, b) we will look at the reports written by the group of students as they summarise the work developed in partnership with companies throughout eight intensive weeks. We will conclude, not with a retrospective view, although it is important to look at the past to build the present, but with the perspective of a future that is collaborative, reflective, critical and increasingly creative.
Towards a Theory of Motivations and Roles in Business Ecosystems
Authors: Mastropetrou Margaret , Bithas George , Kutsikos Konstadinos 
Published: September 2022

Focusing on the role of networking organizational structure, the literature on innovation management has turned towards value co-creation. The need for value co-creation has emerged from the fact that, in order for firms to cater for their customers’ needs, they cannot deliver on their own as single entities, but rather participate in business ecosystems. Ecosystems are a fundamental occurrence of the academic literature, as well as the managerial world. In order to gain insight to the operations of ecosystems, a systematic literature was carried out. The research question concerned the motivations that drive participants to join a business ecosystem. Several frameworks were explored with a focus on the roles that participants might fill and their specific attributes. The findings suggest linking the stakeholders’ motivations to specific roles’ attributes, thus leading to the filling of a certain role. The outcomes are then reflected in the luxury goods industry, which is one of the richest and unmanageable sectors and bears the characteristics of an ecosystem. The contribution of this research is fundamental for the ecosystems operations, as the exploration of stakeholders’ motivations is essential for the sustainability of the ecosystem from a managerial perspective.