bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on development height of water flowing fractured zone in shallow thick coal seam mining of Daheng Coal Mine
Authors: Chang Xikun , Wang Mingguo , Zhu Wei , Fan Jinmeng 
Published: June 2022

Abstract
The height of water flowing fractured zone is a key parameter to implement water-retaining mining technology. In order to study the development height of water flowing fractured zone in shallow thick coal seam mining in ecologically fragile areas of western China, taking 91105 working face of Daheng Coal Mine as the research object, the height of water flowing fractured zone is comprehensively determined by empirical formula, rock tensile rate formula, field test and numerical simulation. The results show that the formula calculation and numerical simulation both are close to the measured results, the upward slant hole observing method is reliable for the height observation of water flowing fractured zone. The maximum height of water flowing fractured zone is 53.62 m, the fracture production ratio is 12.32, and the development form is ' saddle '. Compared with the empirical formula, the calculation results of rock tensile rate formula are closer to the measured results, which improves the prediction accuracy of water flowing fractured zone height. It shows the feasibility of water flowing fractured zone height calculation based on rock tensile rate, and provides a new idea for water flowing fractured zone height prediction. Based on the geological conditions of 91105 working face, the numerical simulation analysis shows that the development of water flowing fractured zone undergoes three stages of slow increase, sudden increase and stability. The research results can provide guidance for the implementation of water-preserved coal mining and ecological environment protection in thick coal seams in ecologically fragile areas in the west.
Potential effects of POLR2H and DYNC1I2 on the immunity and prognosis of neuroblastoma
Authors: Ma Yingxuan , Lu Li , Li Zhi , Xu Weijue , Liu Jiangbin , Guo Ting , Wu Yibo , Tan Kezhe , Wu Wei , Zheng Lulu , Fan Feilong , Gong Zhenhua , Lv Zhibao 
Published: June 2022

Abstract
Objective: The present study utilized bioinformatics techniques and data from the GEO, TARGET, and ArrayExpress databases to compare gene expression in INSS4 and INSS1 neuroblastomas (NBs), thereby identifying metabolites with different levels of expression and predicting the prognosis of patients with NB.METHODS: Genes of patients with INSS4 and INSS1 NBs from the GEO database were screened, with those having | log2fold change (FC) | >3 and adjusted P <0.05 defined as being differentially expressed. These differentially expressed genes (DEGs) were screened to obtain clinical data and RNA sequence datasets from NB patients in the TARGET database. Univariate Cox proportional hazards regression analysis identified prognosis-related genes, which were incorporated into a prognosis model. Based on median risk scores, these patients were divided into high and low-risk groups. Their survival rates were compared, and ROC curves were used to analyze predictive values for NB. NB patients were also divided into two clusters by consensus clustering based on levels of POLR2H and DYNC1I2 expression. Immune infiltration analyses were performed using GSEA, ESTIMATE, CIBERSORT, and ssGSEA. Tumor tissue of 17 NB patients was used for experimental verification and their survival was compared.Result: Analysis of three datasets identified 62 up-regulated genes and 163 down-regulated genes. The prognostic model predicted that the areas under the 3-year and 5-year survival curves were 0.786 and 0.817, respectively. Levels of expression of POLR2H and DYNC1I2 accounted for the highest percentage of risk scores and were included in follow-up analysis. Samples were consistently clustered according to their expression matrix. POLR2H was more highly expressed in cluster 2, whereas DYNC1I2 was more highly expressed in cluster 1. The survival rate of cluster 1 was significantly higher than that of cluster 2. Experimental verification in 17 NB patients showed that these patients could also be divided into two groups, which differed significantly in mortality hazard ratio (HR 9.37 P<0.05).Conclusion: The expression of POLR2H and DYNC1I2 affects the immune microenvironment of NB and can affect patient prognosis. These factors can be used to refine clinical groupings, guide personalized treatment, and suggest new methods for the diagnosis and treatment of NB.
Clinical diagnosis for Chikungunya infection: An essential aid in a primary care setting where serological confirmation is not available
Authors: Rueda Juan C. , Peláez-Ballestas Ingris , Angarita Jose-Ignacio , Santos Ana M. , Pinzon Carlos , Saldarriaga Eugenia-Lucia , Rueda Jorge M. , Forero Elias , Saaibi Diego L. , Pavía Paula X. , Mantilla Marta Juliana , Rodríguez-Salas Gustavo , Santacruz Juan Camilo , Rueda Igor , Cardiel Mario H. , Londono John 
Published: June 2022

Abstract
Background
Chikungunya virus (CHIKV) diagnosis have become a challenge for primary care physicians in areas where zika virus and/or dengue virus are present. Case definitions for the three arboviral infections are overlapping.
Method
A cross-sectional analysis was carried out. A bivariate analysis was made using confirmed CHIKV infection as the outcome. Variables with significant statistical association were included in an agreement consensus. Agreed variables were analysed in multiple regression model. The area under the receiver operating characteristic (ROC) curve was calculated to determine a cut-off value and performance.
Results
295 patients with confirmed CHIKV infection were included. A screening tool was made using symmetric arthritis (4 points), fatigue (3 points), rash (2 points) and ankle joint pain (1 point). The ROC curve identified a cut-off value and a score ≥ 5.5 was considered positive to identify CHIKV patients with a sensibility of 64.4% and a specificity of 87.4%, positive predictive value of 85.5%, negative predictive value of 67.7%, area under the curve of 0.72, and an accuracy of 75%.
Conclusion
We developed a screening tool for CHIKV diagnosis using only clinical symptoms as well as proposed an algorithm to aid the primary care physician.
Improving the quality of the delivery of nutritional care among children with cancer undergoing treatment in Central America
Authors: Damasco-Avila Erika , Sagastizado Stephany Zelaya , Carrillo María , Blanco Jessica , Fu Ligia , Espinoza Darrell , Ladas Elena J. 
Published: June 2022

Abstract
Purpose
International twinning programs have been well-established between institutions in childhood cancer; and have led to pediatric cancer units in low- and middle-income countries (LMICs) adopting multidisciplinary forms of care. To advance nutritional care in LMICs, The International Initiative for Pediatrics and Nutrition (IIPAN) provided the structural framework and personnel for the delivery of nutritional care. We describe the impact of a newly established nutrition program on the delivery of nutritional care and nutrition-related clinical outcomes in children and adolescents undergoing treatment for cancer in Nicaragua and Honduras.
Methods
A prospective cohort (N = 126) collected clinical data over a two-year period. Collection of IIPAN’s nutritional services received during treatment, and clinical data were abstracted from medical charts and registered in REDCap database. Chi-square, ANOVA, and generalized linear mixed models were employed; P < 0.05 was considered statistically significant.
Results
Nutritional assessments led to a higher number of patients receiving recommended standard of care. Children classified as underweight during treatment, presented higher number of infections and toxicities, LOS and days of treatment delays during treatment. Overall, from the start to end of treatment, 32.5% of patients improved nutritional status, 35.7% maintained it and 17.5% worsened. Based in metrics, costs per consultation was under 4.80USD (Honduras) and 1.60USD (Nicaragua).
Conclusion
Integration and equitable access of the nutritional care process for all patients needs to be recognized as a component of the basic management in pediatric oncology care. IIPAN´s nutritional program demonstrates that nutritional care is economical and feasible in a limited resource setting.
Impacts of Climate Change on Irrigation Water Requirement for the Major Grown Crop Production: a Case of Didesa Sub-Basin, Nile Basin of Ethiopia
Authors: Wakjira Chala 
Published: June 2022

Abstract
Natural and man-made activities in the sub-basin have influenced the climate change and induced the hydrology of the watershed. Changes in climate could affect metrological parameters, and thus the available water resource and which directly lead to changes in irrigation water requirement in agriculture. Therefore, this study was conducted to assess the current and future crop water use of major crops grown under climate change scenarios in the Didesa sub basin. For this study, daily metrological data such as maximum temperature, minimum temperature, wind speed, sunshine hours, and humidity and precipitation data were used. Crop and cropping pattern data were used for the study area. Future climate data predicted for the periods 2025, 2055 and 2085 considering both the A2 and B2 scenarios using GCM HadCM3. Crop evapotranspiration (ETo) was calculated using mean monthly climate and rainfall data with help of the CROPWAT 8.0. The crop water requirement (CWR) was determined for each crop in the project area of the study area for the baseline period (2020) and downscaled climate data. Crop water use of tomato crops increased from 1.2% and 1.4 % for H3B2 and H3A2 scenarios, respectively at 2085s. Similarly, sugarcane water requirement increased from 1.5% to 1.8% for H3B2 and H3A2 scenarios, respectively at 2085s. This increasing crop water requirement results in the crop water stress during scenario periods. Therefore, to solve water shortages, alternative sources of water supply such as ground water and water harvesting technologies should be studied and integrated water management systems should be implemented. In addition, to improve the efficiency of irrigation water, different irrigation methods such as drip irrigation should be improved in areas that have implication for driving climate change resilience as early warning.
Advancements in the study of HCC-MVI: the first bibliometric analysis
Authors: He Tao , Zou Jieyu , Sun Ke , Yang Juan , Lei Tingting , Xu Lin , Yin Sineng , Li Guangkuo 
Published: June 2022

Abstract
Purpose
Over the past decade, several studies have been published regarding the microvascular invasion (MVI) of hepatocellular carcinoma (HCC).However, although these publications have had a remarkable impact on MVI, they have not been quantitatively analysed. Therefore, this study characterised the evolution in HCC-MVI research and systematically evaluated scientific outputs using bibliometric citation analysis.
Methods
We conducted a systematic search on the Web of Science Core Collection on 2 May 2022 to retrieve studies related to HCC-MVI published between 2013 and 2022. Then, Citespace (v.5.8R3), VOSviewer (v.1.6.18) and other visualisation tools were used to conduct a bibliometric analysis of the publications.
Results
We identified 1208 articles on MVI in HCC. Of these, while China (n = 518) was the most prolific country, Fudan University (n = 90) was the most notable institution. Furthermore, we observed that while Lau Wan Yee participated in most studies (n = 26), the Frontiers in Oncology (IF2020:6.24) published the highest number of documents (n = 49) on this subject, with 138 publications. The paper ‘Bray F, 2018, CA-CANCER J CLIN, V68, P394’ also presented the highest co-cited references, with 119 citations. Additionally, the top three keywords were ‘survival’, ‘recurrence’ and ‘microvascular invasion’. Moreover, the research hotspots and frontiers in HCC-MVI for the last three years included ‘image’ and ‘tace’.
Conclusion
This study comprehensively summarised the most significant HCC-MVI documents from past literature (2013–2022) and highlighted key contributions made to the advancement of this subject and the advancement of this field over the past decade. We propose that this information would provide clinicians and researchers insight into future directions relative to the advancement of HCC-MVI.
A new global nonlinear force-free coronal magnetic-field extrapolationcode implemented on a Yin-Yang grid
Authors: Koumtzis Argyrios , Wiegelmann Thomas 
Published: June 2022

Abstract
solar coronal plasma. Detailed insights into the coronalmagnetic field are important to understand most of the physicalphenomena there. While direct routine measurementsof the coronal magnetic field are not available, field extrapolation ofthe photospheric vector field measurements into the corona is the onlyway to study the structure and dynamics of the coronal field. Herewe focus on global coronal structures which are traditionally modelledusing spherical grids and synoptic vector magnetograms asboundary conditions. We developed a new code that performs nonlinear force-freemagnetic field extrapolations in spherical geometry.Our new implementation is based ona well-established optimization principle, which was implemented on aCartesian grid and a single spherical finite-difference grid.In the present work, for the first time, thealgorithm is able to reconstruct the magnetic field in the entirecorona, including the polar regions. The finite-differencenumerical scheme that was employed inprevious spherical code versions suffered from numerical inefficienciesbecause of the convergence of those grids on the poles. In our new code,we implementthe so-called Yin-Yang overhead grid, the structure of which addressesthis difficulty. Consequently, boththe speed and accuracy of the optimization algorithm are improvedcompared to the previousimplementations. We tested our new code using the well knownsemi-analytical model (Low and Lou solution), which has frequently been used as a benchmark for nonlinear force-free extrapolation codes.
Satellite-based flood inundation and damage assessment
Authors: Mata Christine B. , Balderama Orlando F. , Alejo Lanie A. , Bareng Jeoffrey Lloyd R. , Kantoush Sameh Ahmed 
Published: June 2022

Abstract

Because recurring floods in the Philippines have become more damaging throughout time, risk assessments, quantifying, and visualizing flood damages as accurately as possible become imperative. To deal with an up-to-date database and a practical assessment tool, a satellite imagery-based method was used which aimed to map flood inundation and estimate damages brought by the flood during Typhoon Ulysses. This paper presents a framework for an integrated flood risk management in a river basin context with the following components as follows: 1) collection of the comprehensive database containing information relevant for flood analysis; 2) use of a satellite-imagery based method for flood inundation map using Google Earth engine; 3) validation of map accuracy through quick post-flood participatory approach. Analysis of the recent flood inundation event in November 2020 in Cagayan Valley, Philippines showed the inundation of an extensive area of 620.88 km2 affecting the Cagayan province at 55.91% and Isabela province at 44% share of inundation. The flood severely affected approximately 614.05 km2 of the total croplands. Using a participatory validation approach, the overall accuracy of datasets used is 97.78% while flood extent is 95%. Through this study, the framework, approach, and methodology can be replicated in other locations in the Philippines and in other countries which recurrently experience flooding.
Black Holes as Geometric Distortional Extrema
Authors: koehler dale 
Published: June 2022

Abstract
It is shown in the present work that the distorted-space model of matter as extended to extreme curvature limits results in characteristics mimicking those of galactic-holes. The distorted-geometry structures exhibit non-Newtonian features wherein the hole or core-region fields of the structures are energetically-repulsive (negative pressure), do not behave functionally in an r-4 manner and terminate at zero at the radial origin (no singularity). Of particular interest is that of r-6 energy-density behavior at structural radial distances near the core of the distortion, a region also displaying potential-well behavior.
Removal of lead, cadmium, and copper from water usingMoringa oleiferaseed biomass
Authors: Nwagbara Victor Uzoma , Chigayo Kayini , Iyama William Azuka , Kwaambwa Habauka Majority 
Published: June 2022

AbstractThis study demonstrated that Moringa oleifera seed biomass (MOSB) has the potential to be used as a natural alternative in the removal of lead (Pd), cadmium (Cd), and copper (Cu) from water which was justified by the level of toxicity, environmental unfriendliness, and costly nature of chemical coagulants presently used. The Fourier Transform Infrared (FTIR) analysis was used to identify the MOSB and functional groups present in the adsorption of metal ions. The maximum removal at pH 5, room temperature, and 0.8 g dosage was 90, 81.77, and 70% for Pb(II), Cd(II), and Cu(II), respectively. The order of biosorption preference was Pb(II)&gt;Cd(II)&gt;Cu(II) in single sorption and is in a consistent correlation between physiochemical properties of metal ions and selective biosorption of MOSB functional groups. The adsorption data fitted better to the Langmuir than the Freundlich models as the sorption capacities (qm) of MOSB for Pb(II), Cd(II), and Cu(II) were 6.19, 5.03, and 3.64 mg/g, respectively. The separation factor (RL) was within the range of 0–1 which showed that the Pb(II), Cd(II), and Cu(II) adsorption processes were favourable for M. oleifera adsorbent. The results showed that MOSB is an effective adsorbent in the removal of the studied heavy metals from contaminated water. In all these water-purifying properties of the moringa seed biomass, no deliberate attempt has been made to study the use of a ternary system of very toxic metals like Pb, Cd, and Cu knowing the anti-bacterial properties of the metal system. Similarly, the reproducibility, low cost, and no requirement of a power source make this an efficient process for obtaining potable water even in homes in rural settings.
DYRK1A Inhibitors and Perspectives for the Treatment of Alzheimer's
Disease
Authors: de Souza Márcia Maria , Cenci Arthur Ribeiro , Teixeira Kerolain Faoro , Machado Valkiria , Mendes Schuler Majory Christina Garcia , Gonçalves Ana Elisa , Paula Dalmagro Ana , André Cazarin Camila , Gomes Ferreira Leonardo Luiz , de Oliveira Aldo Sena , Andricopulo Adriano Defini 
Published: June 2022

Background:
Alzheimer's disease (AD) is a chronic neurodegenerative disease
and the most common form of dementia, especially in the elderly. Due to the increase in
life expectancy, in recent years, there has been an excessive growth in the number of people
affected by this disease, causing serious problems for health systems. In recent years,
research has been intensified to find new therapeutic approaches that prevent the progression
of the disease. In this sense, recent studies indicate that the dual-specificity tyrosine
phosphorylation regulated kinase 1A (DYRK1A) gene, which is located on chromosome
21q22.2 and overexpressed in Down syndrome (DS), may play a significant role in developmental
brain disorders and early onset neurodegeneration, neuronal loss and dementia
in DS and AD. Inhibiting DYRK1A may serve to stop the phenotypic effects of its overexpression
and, therefore, is a potential treatment strategy for the prevention of ageassociated
neurodegeneration, including Alzheimer-type pathology.

Objective:
In this review, we investigate the contribution of DYRK1A inhibitors as potential
anti-AD agents.

Methods:
A search in the literature to compile an in vitro dataset including IC50 values involving
DYRK1A was performed from 2014 to the present day. In addition, we carried
out structure-activity relationship studies based on in vitro and in silico data.

Results:
molecular modeling and enzyme kinetics studies indicate that DYRK1A may
contribute to AD pathology through its proteolytic process, reducing its kinase specificity.

Conclusion:
further evaluation of DYRK1A inhibitors may contribute to new therapeutic
approaches for AD.
Alternative Methods for Pulmonary-Administered Drugs Metabolism: A
Breath of Change
Authors: Cabral Lucio Mendes , Suzuki Érika Yoko , Simon Alice , Souza Domingos Thaisa Francielle , de Azevedo Abrahim Vieira Bárbara , de Souza Alessandra Mendonça Teles , Rodrigues Carlos Rangel , de Sousa Valeria Pereira , do Carmo Flávia Almada 
Published: June 2022

Abstract:
Prediction of pulmonary metabolites following inhalation of a locally acting pulmonary
drug is essential to the successful development of novel inhaled medicines. The lungs present metabolic
enzymes, therefore they influence drug disposal and toxicity. The present review provides an
overview of alternative methods to evaluate the pulmonary metabolism for the safety and efficacy of
pulmonary delivery systems. In vitro approaches for investigating pulmonary drug metabolism were
described, including subcellular fractions, cell culture models and lung slices as the main available
in vitro methods. In addition, in silico studies are promising alternatives that use specific software to
predict pulmonary drug metabolism, determine whether a molecule will react with a metabolic enzyme,
the site of metabolism (SoM) and the result of this interaction. They can be used in an integrated
approach to delineate the major cytochrome P450 (CYP) isoforms to rationalize the use of in
vivo methods. A case study about a combination of experimental and computational approaches was
done using fluticasone propionate as an example. The results of three tested software, RSWebPredictor,
SMARTCyp and XenoSite, demonstrated greater probability of the fluticasone propionate
being metabolized by CYPs 3A4 at the S1 atom of 5-S-fluoromethyl carbothioate group. As
the in vitro studies were not able to directly detect pulmonary metabolites, those alternatives in silico
methods may reduce animal testing efforts, following the principle of 3Rs (Replacement, Reduction
and Refinement), and contribute to the evaluation of pharmacological efficacy and safety profiles
of new drugs in development.
Melanocyte Adhesion and Apoptosis in Vitiligo: Linking Puzzle Blocks
Authors: Srivastava Niharika , Gupta Sarika , Parsad Davinder 
Published: June 2022

Abstract:
Vitiligo is the utmost common depigmenting condition consequential from
melanocyte loss from the basal layer of the epidermis. Vitiligo disease mostly affects
dark-skinned races and makes them more sensitive to UV radiation. It is also linked with
some autoimmune diseases and various psychosocial difficulties. Melanocyte loss leads
to depigmentation in vitiligo, is a major concern over decades, and even affects an
individual’s day-to-day life severely. All the theories, including autoimmune, autocytotoxic,
and neural, collectively decipher either prime impact on the melanogenesis
inhibition or deficient adhesion inspired melanocytes disappearance. Previously it has
been described that melanocyte loss in vitiligo patients is caused by defective adhesion.
Melanocyte death by apoptosis mainly occurs due to melanocyte detachment or
migration from the basal layer and further followed by transepidermal migration. Various
cell surface molecules, i.e., cell adhesion molecules (CAMs) in affiliation with
neighbouring cells and extracellular matrix (ECM), encompass a typical cell adhesion
process. All these ECM molecules along with transcription factors, help in the survival
and maintenance of pigmentary cells/melanocytes. Therefore, in this issue, we have
tried to compile the literature available on melanocyte detachment/apoptosis in ECM due
to the alteration in adhesion molecules and matrix metalloproteinases (MMPs) driven by
known/unknown transcription factors.