bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of workpiece surface texture on visual measurement of roughness
Authors: Yi Huaian , Lu Lingli , Shu Aihua , Qin Jianhua , Lu Enhui 
Published: August 2022

Abstract
In view of the universal applicability of color information index and the ability of spectrum index to measure small roughness, this paper studies the influence of machined surface texture on roughness machine-vision measurement. Based on the micro-topography of different types of texture surface, the correlations between the average color difference, five typical spectral indices and the surface roughness parameters of two types of texture representative workpiece milling and grinding are focused on in the discussion. On this basis, the influences of the angle of light source and camera relative to the surface normal of the sample and the sample surface texture direction on roughness measurement are further discussed, and the reasons for the difference in index to characterize different process roughness are analyzed from the mechanism. The experimental results show that the different surface textures have different effects on light scattering, which in turn affects the sensitivity of the index to the roughness parameters.
Design, synthesis, and molecular docking study of novel cinnoline derivatives as potential inhibitors of tubulin polymerization
Authors: Mahmoud Eman Mohammad , Shongwe Musa , Moghadam Ebrahim Saeedian , Moghimi-Rad Parsa , Stoll Raphael , Abdel-Jalil Raid 
Published: August 2022

Abstract
The preparation of a novel 4-methylbenzo[h] cinnolines entity via a three-step synthetic protocol is described. Cyclization of the naphthylamidrazones, in the presence of polyphosphoric acid (PPA), furnishes the respective target benzo[h]cinnolines directly. This one-pot synthesis involves intramolecular Friedel–Crafts acylation followed by instant elimination under heating conditions. It is noteworthy that the yield of the product from this step decreases dramatically if the heating is extended beyond 3 h. The target novel cinnolone derivatives were identified by mass spectrometry and their structures elucidated by spectroscopic techniques. Subsequently, molecular docking was performed to shed light on the putative binding mode of the newly synthesized cinnolines. The docking results indicate that these derivatives are potential inhibitors of tubulin polymerization and the best interaction was achieved with a computational ki = 0.5 nM and posed correctly over the lexibulin.
Vertragstypenzwang im Code civil? Die Gültigkeit gegenseitiger Verträge in der Judikatur der Freien Stadt Krakau (1815–1846)
Authors: Dziadzio Andrzej 
Published: August 2022

Abstract

Contract-nominalism in the Code civil? The validity of bilateral agreements in the judicature of the courts of the Free City of Krakow (1815–1846). The courts of the Free City of Kraków, when applying Article 1325 of the Code civil, adopted a different direction from the courts in Baden or the French judiciary, both of which modified its strict content. In addition to the differences between the Polish, German and French judicatures, there were inconsistencies between individual judgements relating to the form of bilateral agreements in all three cases. As a result, the citizens of the Free City of Kraków, the Grand Duchy of Baden, or France, had no sufficient certainty as to whether their contracts would be adequately protected in the event of a dispute between the parties. The analyzed cases show a convergence of the jurisprudence of the Baden and French courts, which presented a bolder approach to the issue of the validity of bilateral agreements, thereby protecting the Code Civil principle of the freedom of contracts. Kraków courts refrained from such a creative interpretation of the article 1325 and based their rulings on its literal wording. This was partly due to the fact that Polish scholars and judges did not have easy access to the achievements of French jurisprudence at that time. The courts of Baden adjudicated in more favourable conditions, because French and German legal thoughts on the implementation of Code Civil intertwined and complemented each other.
Vorläufige Beobachtungen zu einem Mammutverfahren am Oberappellationsgericht Lübeck (1819–1835)
Authors: Falk Ulrich 
Published: August 2022

Abstract

Preliminary Observations on a Mammoth Civil Procedure at the Oberappellationsgericht Lübeck (1819–1835). This miscellany reviews an important contribution to the research on German judicature in the 19th century by legal historian Peter Oestmann: “Zur Gerichtspraxis im 19. Jahrhundert. Ein Schmuggeleiprozess am Oberappellationsgericht Lübeck”, two parts, 2019. His edition contains the complete text of five case files of a fiercely contested civil trial, the so-called “smuggling case”. The judges, headed by their presiding judge Arnold Heise, a former professor in Heidelberg and Göttingen and famous representative of the German Pandektenwissenschaft, did their very best. Nevertheless, it took them 16 years to put an end to this intractable legal and social conflict. The far from convincing result of their efforts raises questions, outlined in the second part of the miscellany. Further research has to be conducted to reach conclusions.
Efficacy and Safety Results of Different Ablation Technologies for Persistent Atrial Fibrillation Treatment
Authors: Baimbetov Adil , Bizhanov Kenzhebek , Yakupova Ilinara , Jukenova Aiman , Ualiyeva Aliya , Tursunkhanov Zhalolkhan , Bigeldiyev Nurbolat 
Published: August 2022

Introduction: Pulmonary vein isolation is the primary goal in treating patients with paroxysmal atrial fibrillation using catheter ablation. This study's purpose is a comparative assessment of the efficacy and safety of two strategies for catheter treatment in patients with persistent atrial fibrillation.
Patients and methods: The study included 127 patients with persistent atrial fibrillation during the last six months before inclusion in the study. The average follow-up period was 24 months.
Results: The primary efficacy endpoint (death, cerebrovascular event, or serious complications associated with treatment) occurred in 15 patients in the cryoballoon ablation group and 14 patients in the radiofrequency ablation group. The Kaplan-Meier survival estimates were 30% and 28%, and the risk ratio 0.96 and 95% of the confidence interval.
Conclusions: The treatment in patients with persistent atria fibrillation, using catheter ablation with contact force control catheter treatment with the pulmonary vein isolation, was more efficient.
How to Combine Student Science Education with Modern Environmental Education
Authors: Chepok Andrii , Yevtushenko Natalia 
Published: August 2022

This work is devoted to current problems of modern education: the formation and development of scientific thinking of the individual from the school age and the improvement of environmental education of students both of high school and older ones, since the authors do believe that these issues are interrelated. In this paper, some issues of students’ scientific education are considered from the standpoint of strengthening the science intensity of the proposed educational content. The authors, being in the systems of secondary and higher schools and based on their own professional experience, found their way to improve the level of scientific education of students by involving them in educational environmental/bionic research works in the form of IT projects. The students’ work on such a project implies the main stages of modern researching – from mathematical modeling of a selected natural phenomenon to mathematical processing of the corresponding computer experiment results and their interpretation. The organization of training-and-research activities of high school students and working on such researches have several positive outcomes, one of which is not only the improvement of knowledge in the Natural sciences, but also other positive aspects related to certain types of human thinking – critical, algorithmic, logical and creative ones. The authors believe that significant success in conducting student research can be achieved by working with “ordinary-and-average” but motivated students. The authors prove with their practical experience that it is possible to identify and educate young people with qualities (maybe with talents!) of researchers in time. The paper also points an important question about the contents of modern education at the secondary school and higher levels.
Inclusion in the Dimensions of Personality
Authors: Vasianovych Hryhoriy , Budnyk Olena 
Published: August 2022

The article substantiates and offers a personalized approach to the analysis of the problem of inclusion. It emphasizes the need to adhere to the principle of human and child-centeredness in the process of working with people with special needs. It provides not only a humane, democratic attitude to a person, but also gives the opportunity to take full advantage of psychological and pedagogical influences on the spiritual development of the individual. An important element of this process is the active use of various ways and forms of mutual understanding, based on charity, empathy (methodology of Hermeneutics and Phenomenology). For factual analysis and presentation of the outlined problem, the real life of prominent domestic and foreign personalities with serious health problems (hearing loss – Ludwig van Beethoven, Maria Bashkirtseva, blindness – Homer, Democritus, Louis Braille, paralysis and cancer – Stephen Hawking, Kvitoslava Tsisyk, Yuri Titov), but showed great will power, the desire for self-realization by means of creativity in the field of music, poetry, fine arts was used. These personalities set an example to follow in an inclusive educational institution.
An epilepsy curriculum for primary health care providers: a report from the Education Council of the International League Against Epilepsy
Authors: Singh Gagandeep , Braga Patricia , Carrizosa Jaime , Prevos‐Morgant Marielle , Mehndiratta Man Mohan , Shisler Priscilla , Triki Chahnez , Wiebe Samuel , Wilmshurst Jo , Blümcke Ingmar 
Published: August 2022

AbstractObjective. Primary health care providers are directly responsible for the care of people with epilepsy. However, their education about epilepsy might be inadequate or lacking. Our objective was to develop an evidence‐based and consensus‐driven educational curriculum for the management of epilepsy within the primary healthcare setting.Methods. The International League Against Epilepsy (ILAE) Education Council commissioned a task force of international experts, who met virtually at monthly intervals in 2020/2021 to develop the curriculum. The task force adopted and added to five domains from the ILAE Epileptology Curriculum after discussions on context, structure and wording of associated competencies and learning objectives. The consensus‐approved curriculum was disseminated to the ILAE leadership and constituency in six different languages. An online survey was used to collate structured feedback which further refined the curriculum.Results. Feedback was obtained from 785 voluntary respondents who were inclusive of epilepsy specialists and primary healthcare providers. Nearly two thirds of the respondents approved the use of the curriculum to advance the competency of primary health care providers in epilepsy. The final educational curriculum comprised six domains, 26 competencies and 85 learning objectives. The six domains were: (1) ability to diagnose epilepsy and its broad subtypes; (2) ability to provide counselling to people with epilepsy over a range of issues; (3) ability to introduce treatment and follow‐up to people with epilepsy; (4) competency to appropriately refer people to higher centres of care; (5) ability to manage epilepsy emergencies including status epilepticus; and (6) ability to recognize and provide basic care for psychiatric and somatic comorbidities.Conclusions. The curriculum represents an advance in providing inclusive care for epilepsy within the primary health care setting and ideally should be used to facilitate future primary health care epilepsy education packages.
Dispositivo materno perante a condição de mulheres em amamentação que vivem com HIV
Authors: Mazuze Bento Saloio Daniel , Borges Thayná Davi de Souza , Selemane Joaquim Mário 
Published: August 2022

INTRODUÇÃO: Muitos são os papéis socialmente atribuídos às mulheres no contexto da maternidade e especialmente no processo de amamentação. Num contexto de mulheres vivendo com HIV/aids, a amamentação e o risco de transmissão vertical do HIV aponta para particulares implicações. OBJETIVO: Este estudo tem por objetivo discutir sobre os impactos dos dispositivos e tecnologias de gênero relacionados às experiências das mulheres vivendo com HIV e em processo de amamentação. MÉTODO: Para isso, a partir de delineamento qualitativo e exploratório, foi realizada uma revisão da literatura nas plataformas Scielo, Biblioteca Virtual em Saúde (BVS) e Biblioteca Digital de Periódicos, possibilitando a exploração de questões à luz de produções sobre o tema e tornando possível reflexões acerca dos temas abordados. Buscou-se ainda selecionar e incluir livros e outras obras clássicas relevantes a essa temática específica. RESULTADOS: Foram selecionados 7 publicações, segundo a relação com os objetivos deste estudo, além de outras obras com relevância para a temática em questão, que revelaram a existência de sentimentos ambivalentes como: raiva, tristeza, sentimento de culpa e a necessidade de proteger a criança diante da (im)possibilidade de transmitir o HIV. CONSIDERAÇÕES FINAIS: A busca indica que existe uma larga possibilidade de estabelecer de forma histórica, social e cultural a relação entre a tecnologia do gênero, dispositivo materno e a transmissão vertical do HIV.
The rs1940475 polymorphism in the MMP8 gene as a protective factor of severe breast cancer
Authors: Pavlova N. V. , Ponomarenko I. V. , Churnosov M. I. 
Published: August 2022

Aim: to investigate an association between polymorphism in the MMP2, MMP8, MMP9 genes and severe breast cancer (BC).Materials and Methods. Retrospective comparative study was conducted by assessing a cohort of 345 BC patients: 254 patients at stage I–II and 91 at stage III–IV. Genotyping of the three single nucleotide polymorphisms in the MMP2 (C>T rs243865), MMP8 C>T rs1940475), and ММР9 (C>T rs3918242) genes was performed. A comparative analysis of the genetic characteristics of patients with stage I–II and stage III–IV of the disease was performed.Results. The allele variant T rs1940475 (C>T) of the MMP8 gene in BC patients at stage I–II (0.512) was found by 1.2-fold more often compared with patients at stage III–IV of the disease (0.428; pperm = 0.05). According to allelic (odds ratio (OR) = 0.71; 95 % confidence interval (CI) = 0.51–1.00; pperm = 0.05) and additive (OR = 0.69; 95 % CI = 0.48–0.99; pperm = 0.05) genetic models, the allele T rs1940475 (C>T) of the MMP8 gene has protective effect for developing stage III–IV BC. The polymorphic locus rs1940475 (C>T) determines the amino acid substitution in the MMP8 protein (p.K87E) and DNA binding to the transcription factors NF-AT1, MYC and CIZ, is associated with the expression of the genes MMP27 and RP11-817J15.3 acting as an enhancer regulatory site in primary breast epithelial cells. Single nucleotide polymorphism in the MMP2 (C>T rs243865), ММР9 (C>T rs3918242) genes is not associated with severe BC (stages III–IV).Conclusion. The single nucleotide polymorphism rs1940475 in the MMP8 gene is a protective factor protecting against severe BC course.
National Practices Regarding Doctor of Nursing Practice (DNP) Projects
Authors: Scruggs Corey Jeannie , Roussel Linda , Zellefrow Cindy , Guthrie Sharon 
Published: August 2022

BackgroundAACN published a clarifying document in 2015 to guide Doctor of Nursing Practice (DNP) programs’ DNP Scholarly Projects. This publication provided specific and general guidance; however, areas of inconsistent interpretation remained. The variability of best practices for DNP projects sparked the idea for a national survey to explore how projects are being carried out and to determine if the varied approaches align with AACN’s 2015 recommendations.ObjectiveThis nationwide study’s purpose was to describe DNP Scholarly Project processes and to determine alignment with AACN’s 2015 DNP project recommendations.MethodsA descriptive survey was deployed to DNP programs across the country.ResultsNational DNP project practices were identified as well as gaps in alignment with AACN recommendations.Conclusions and Implications for NursingThe results of this study provided a national snapshot of how DNP programs are executing DNP projects. Rich dialogue and ongoing exploration about DNP project best practices continue because of this work.
Alternativas ao paraquat para o controle químico de azevém, aveia e buva
Authors: Albrecht Alfredo Junior Paiola , Albrecht Leandro Paiola , Pasini Mauricio Paulo Batistella , Silva André Felipe Moreira , Larini Willian Felipe , Neuberger Debora Cristine 
Published: August 2022

Com o banimento do paraquat, é necessário planejar o uso de herbicidas alternativos na dessecação de plantas daninhas. Neste sentido desatacam-se herbicidas como glufosinate, saflufenacil, diquat, glyphosate, clethodim, em diferentes associações. Acredita-se que o glufosinate, sobretudo em associações, seja eficaz no controle de Lolium perenne ssp. multiflorum (azevém), Avena fatua (aveia) e/ou Conyza sumatrensis (buva). Objetivou-se avaliar a eficácia de glufosinate isolado, ou em associações, no controle de azevém, aveia e buva, como alternativa ao paraquat. O experimento foi conduzido em área experimental localizada no município de Cruz Alta, estado do Rio Grande do Sul (RS), Brasil, em novembro de 2020. Foi utilizado delineamento inteiramente casualizado, com quatro repetições. Os tratamentos foram compostos pela aplicação de glufosinate, saflufenacil, diquat, glyphosate e clethodim, isolados ou em associações. Foi avaliado o controle de azevém, aveia e buva, aos 7, 14 e 28 dias após aplicação. O glufosinate em associações foi eficaz no controle das plantas daninhas, sendo quase sempre superior ao observado para diquat isolado ou em misturas. Para se antingir a mesma eficácia das associações, a dose de glufosinate deve ser de no mínimo 700 g i.a. ha-1. A aplicação de glufosinate (400 g i.a. ha-1) em associações com saflufenacil, glyphosate e clethodim foi eficaz no controle de azevém, aveia e buva. A aplicação isolada de glufosinate se mostrou eficaz no controle de todas as plantas daninhas na dose máxima aplicada (700 g i.a. ha-1). O glufosinate, isolado ou em associações, caracteriza-se assim alternativa ao paraquat no controle de plantas daninhas.
Pengembangan Bisnis Pengelolaan Sampah di Desa Kalibagor Banyumas
Authors: Susanto Irwan , Fitriana Gita Fadila , Syahrial Antyka 
Published: August 2022

Sampah merupakan salah satu permasalahan yang sedang dihadapi oleh seluruh negara di dunia, tidak terkecuali Indonesia. Sebagai wujud kepedulian pemerintah Indonesia sudah berupaya untuk mengurangi sampah melalui beberapa kegiatan. Cara mengatasi masalah sampah ditempuh salah satunya dengan mengubah persepsi masyarakat terhadap sampah dan perilaku masyarakat dalam menangani sampah, khususnya bagi masyarakat perkotaan. Upaya inovasi penanganan sampah sehingga mampu menciptakan nilai ekonomi sampah merupakan harapan baru dalam penanganan sampah. Permasalahan ini diselesaikan dengan teknik pengelolaan sampah, pengelolaan transaksi ekonomi sampah dan pemasaran. Hasil pengabdian masyarakat secara langsung adalah Badan Usaha Milik Desa (Bumdes) memiliki skrip rancangan strategi bisnis Bumdes dalam bentuk Business Model Canvas, dimana semula belum memiliki. Pelaksanaan operasional Bumdes semula didasarkan atas ide pengelola tanpa melalui penyusunan strategi terstruktur. Pelaksanaan operasional berdasarkan atas rancangan strategi bisnis dan program-program kerja yang sudah terstruktur. Melalui pedoman pada acuan rancangan strategi, pengelola tidak perlu lagi kebingungan memikirkan langkah operasional dalam menjaga keberlanjutan bisnis namun cukup mengikuti acuan strategi bisnis yang disusun.
erapa kegiatan. Cara mengatasi masalah sampah ditempuh salah satunya dengan mengubah persepsi masyarakat terhadap sampah dan perilaku masyarakat dalam menangani sampah, khususnya bagi masyarakat perkotaan. Upaya inovasi penanganan sampah sehingga mampu menciptakan nilai ekonomi sampah merupakan harapan baru dalam penanganan sampah. Permasalahan ini diselesaikan dengan teknik pengelolaan sampah, pengelolaan transaksi ekonomi sampah dan pemasaran. Hasil pengabdian masyarakat secara langsung adalah Badan Usaha Milik Desa (BumDes) memiliki skrip rancangan strategi bisnis BumDes, dimana semula belum memiliki. Pelaksanaan operasional BumDes semula didasarkan atas ide pengelola tanpa melalui penyusunan strategi terstruktur. Pelaksanaan operasional berdasarkan atas rancangan strategi bisnis dan program-program kerja yang sudah terstruktur. Melalui pedoman pada acuan rancangan strategi, pengelola tidak perlu lagi kebingungan memikirkan langkah operasional dalam menjaga keberlanjutan bisnis namun cukup mengikuti acuan strategi bisnis yang disusun.
Self-assembled DNA nanostructure containing oncogenic miRNA-mediated cell proliferation by downregulation of FOXO1 expression
Authors: Kar Avishek , Kumari Kanchan , Mishra Sandip K. , Subudhi Umakanta 
Published: August 2022

Abstract
FOXO1 transcription factor is not only limit the cell cycle progression but also promote cell death as a tumor suppressor protein. Though the expression of FOXO1 is largely examined in breast cancer, the regulation of FOXO1 by miRNA is yet to be explored. In the current study, self-assembled branched DNA (bDNA) nanostructures containing oncogenic miRNAs were designed and transfected to MCF7 cell lines to decipher the FOXO1 expression. bDNA containing oncogenic miRNA 27a, 96 and 182 synergistically downregulate the expression of FOXO1 in MCF7 cells. The down-regulation is evident both in mRNA and protein level suggesting bDNA having miRNA sequences can selectively bind to mRNA and inhibit translation. Secondly, the downstream gene expression of P21 and P27 are also significantly downregulated in presence of miR-bDNA nanostructures. The cell proliferation activity was progressively increased in presence of miR-bDNA nanostructure which confirms the reduced tumor suppression activity of FOXO1 and the downstream gene expression. This finding can be explored to design novel bDNA structures which can downregulate the tumor suppressor protein in normal cells and induce cell proliferation activity to identify early phase markers of cancer.