bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invasive Fungal Diseases Impact On Outcome of Childhood ALL – An Analysis of the International Trial AIEOP-BFM ALL 2009
Authors: Lehrnbecher Thomas , Groll Andreas , Cesaro Simone , Alten Julia , Attarbaschi Andishe , Barbaric Draga , Bodmer Nicole , Conter Valentino , Izraeli Shai , Mann Georg , Moericke Anja , Niggli Felix , Schrappe Martin , Stary Jan , Zapotocka Ester , Zimmermann Martin , Elitzur Sarah 
Published: August 2022

AbstractIn children with acute lymphoblastic leukemia (ALL), risk groups for invasive fungal disease (IFD) with need for antifungal prophylaxis are not well characterized, and with the advent of new antifungal compounds, current data on outcome are scarce. Prospectively captured severe adverse event reports of children enrolled in the international, multi-center clinical trial AIEOP-BFM ALL2009 were screened for proven/probable IFD, defined according to the updated EORTC/MSG consensus definitions. In a total of 6136 children (median age 5.2 years), 224 proven/probable IFDs (65 yeast and 159 mold) were reported. By logistic regression, the risk for proven/probable IFDs was significantly increased in children ≥ 12 years and those with a blast count ≥ 10% in the bone marrow on day 15 (P < 0.0001 each). Proven/probable IFDs had a 6-week and 12-week mortality of 10.7% and 11.2%, respectively. In the multivariate analysis, the hazard ratio for event-free and overall survival was significantly increased for proven/probable IFD, age ≥ 12 years, and insufficient response to therapy (P < 0.001, each). Our data define older children with ALL and those with insufficient treatment-response at high risk for IFD. As we show that IFD is an independent risk factor for event-free and overall survival, these patients may benefit from targeted antifungal prophylaxis.
Low-dose interleukin-2 alleviates neuroinflammation and improves cognitive impairment in high-fat diet mice
Authors: Chen Zheng , Sui Guanghong , Yang Caixia , Wang Feng 
Published: August 2022

Abstract
Background
Interleukin-2 was originally thought to be a proinflammatory factor, but recent studies have revealed that low-dose interleukin-2 might have an anti-inflammatory property. The aim of the study was to reveal whether the cytokine inhibited neuroinflammation in a high-fat diet mouse model and to further reveal the mechanism involved.
Methods
Mice were treated with a single administration of an AAV-interleukin-2 or AAV-LUC vector. Then, the mice were fed a normal or high-fat diet for 12 weeks, followed by a 4-week intervention period. During the intervention period, some of the mice were treated with CREB inhibitor 666 − 15. Then, cognitive function and depression-like behavior were assessed using the Morris water maze, sucrose preference test and tail suspension test. The expression of p-CREB, several microglial polarizations and inflammasome markers were measured using western blotting. The rate of pyroptosis and expansion and activation of Tregs were assessed using flow cytometry.
Results
A high-fat diet caused cognitive impairment and depression-like behavior in the mice. Meanwhile, the high-fat diet also inhibited the expansion and activation of Tregs, promoted microglial M1 polarization, activated the NLRP3 inflammasome and pyroptosis in the hippocampus, and eventually induced significant neuroinflammation in the hippocampus. Low-dose IL-2 using an AAV vector reversed these cognitive, behavioral and pathophysiological abnormalities. However, 666 − 15 treatment weakened the protective effect of IL-2 and aggravated cognitive impairment, neuroinflammation and all other abnormalities in the mice.
Conclusion
Low-dose interleukin-2 alleviated neuroinflammation and cognitive impairment by activating CREB signaling in high-fat diet mice.
Does School Psychology Literature Address the Inequities in the Assessment Practices for Special Education Eligibility Under Emotional Disturbance?
Authors: Alba Laura Alicia , Bains Bhawandeep K. 
Published: August 2022

Abstract
There is a significant need for school psychology research to examine the current assessment practices used when determining special education eligibility under Emotional Disturbance (ED). Specifically, the field has provided ample evidence of the disproportionate rates of Black students eligible under ED, yet our assessment practices as school psychologists have not been evaluated as potential contributors to this systemic oppression in schools. Given the shift towards using a social justice and anti-racism approach in school psychology, we urge scholars and practitioners to investigate the inequities of the current assessment process for identifying ED eligibility by highlighting the dearth of published literature on this topic. That is, the present study systematically reviewed 135 studies that focused on discussing disproportionately in the assessment process for ED eligibility and were published in top school psychology journals. Results revealed that only six articles (4.44%) explicitly discussed disproportionately in assessment procedures for ED eligibility. This paucity of research in the field of school psychology places challenges in using an equity and anti-racist approach to assessment among a highly subjective eligibility category that often places students from minoritized backgrounds in special education. Recommendations for continuing research on equity and anti-racist approaches to the assessment process in ED eligibility are discussed.
Stress granules affect the dual PI3K/mTOR inhibitor response by regulating the mitochondrial unfolded protein response
Authors: Lin Nan , Sun Liankun , Chai Jiannan , Qi Hang , Zhao Yuanxin , Ma Jiaoyan , Xia Meihui , Xiaoqing Hu 
Published: August 2022

Abstract
Drug resistance remains a challenge in ovarian cancer. In addition to aberrant activation of relevant signaling pathways, the adaptive stress response is emerging as a new spotlight of drug resistance in cancer cells. Stress granules (SGs) are one of the most important features of the adaptive stress response, and there is increasing evidence that SGs promote drug resistance in cancer cells. In the present study, we compared two types of ovarian cancer cells, A2780 and SKOV3, using the dual PI3K/mTOR inhibitor, PKI-402. We found that SGs were formed and SGs could intercept the signaling factor ATF5 and regulate the response of mitochondrial unfolded protein(mtUPR)in A2780 cells. Therefore, exploring the network formed between SGs and membrane-bound organelles, such as mitochondria, may provide new insight into the mechanisms of action of antitumor drugs.
Deep Learning with Class Imbalance for Detecting and Classifying Diabetic Retinopathy on Fundus Retina Images
Authors: Kamal Kamel , Mohamed Rania. A. , Darwish Ashraf , Hassanien Aboul Ella 
Published: August 2022

Abstract
Diabetes mellitus is a disorder that causes diabetic retinopathy and is the primary cause of blindness worldwide. Early detection and treatment are required to reduce or avoid vision degradation and loss. For that purpose, various artificial-intelligence-powered approaches for detecting and classifying diabetic retinopathy on fundus retina images have been proposed by the scientific community. This article explores solutions to diabetic retinopathy detection by using three recently developed deep neural networks that have proven effective and efficient. Densenet201, Resnet101, and EfficientNetb0 deep neural network families have been applied to detect and classify diabetic retinopathy on fundus retina images. The dataset was notably not equilibrium; the widespread majority had been normal images, while mild Diabetic retinopathy images made up a very minor percentage of the total dataset. To treatment the skewed distribution and to keep away from biased classification results different scenarios have been used to balance the classes by utilizing (i) weight balancing with data augmentation; (ii) oversampling with data augmentation; (iii) focal loss with data augmentation, and (iv) a hybrid method of oversampling with a focal loss with data augmentation that improves the deep neural network performance of fundus retina images classification with the imbalanced dataset to build an expert system that can rapidly and adequately detect fundus images. The experimental results indicated that using Densenet201, Resnet101, and EfficientNetb0, with weight balancing on the dataset, substantially improves diabetic retinopathy prediction, by re-weighting each class in the loss function, a class that represents an under-represented class will receive a larger weight. The models yielded 94.74%, 94.74%, and 93.42%, respectively, on the test data set.
Investigation of local stress field in the north-central Kinki district by dense seismic observation of stress rotation near the active faults
Authors: Tanaka Toshio , Iio Yoshihisa , Katao Hiroshi , Sawada Masayo , Tomisaka Kazuhide 
Published: August 2022

Abstract
Several active faults are distributed in the north-central Kinki district, making it one of the areas with their highest concentrations in Japan. The orientation of the maximum principal stress (σ1) in southwest Japan is generally in the east-west direction. In the north-central Kinki district, σ1 is also considered to be oriented uniformly in the east-west direction. However, the Arima-Takatsuki fault zone in this district is a vertical strike-slip fault with a strike that is close to east-west, and the angle that the surface trace of the fault makes with the north is 80°. The Mitoke fault zone is also a vertical strike-slip fault with an angle of 110°. The stress field is less likely to cause a strike-slip motion in these fault zones. Thus, in this study, we comprehensively examined whether the orientation of σ1 is uniform. We then investigated the relationship between the orientation of σ1 and the strike of fault. The mechanism solutions were obtained using a large amount of seismic data between November 17, 2008 and March 29, 2018. The stress fields were estimated by stress tensor inversion. At a depth of 10 km near the Arima-Takatsuki fault zone, the average optimum solution for the azimuth of σ1 was 104°, rotating clockwise from the east. The angle between this azimuth and the direction of the surface trace of the fault was 24°. In the Mitoke fault zone, the azimuth of σ1 was 81° and the angle was 29°. These results indicated that the stress field is not uniform and that σ1 rotates in an orientation that easily causes strike-slip motion for strike-slip faults. To elucidate the cause of the σ1 rotation, we assumed that the ductile fault extends into the lower crust as the deeper extension of the brittle fault zone and showed that the stress field in the upper crust rotating near these two fault zones can be explained by aseismic slip on the ductile faults. The findings indicated that the activity of the upper crust is closely related to that of the lower crust and more detailed analysis of the lower crust is essential.
Sarcopenia is associated with worse surgical complications but not relapse-free survival and overall survival in patients with retroperitoneal liposarcoma
Authors: Zhao Mingkun , Lv Minzhi , Fang Yuan , Zhuang Aobo , Wu Qian , Tong Hanxing , Lu Weiqi , Zhang Yong 
Published: August 2022

Abstract
Objective
This investigation aimed to explore the relationship between sarcopenia and severe postoperative complications, relapse-free survival(RFS), and overall survival(OS) in patients with retroperitoneal liposarcoma (RLPS).
Material and methods
This retrospective study included 72 RLPS patients (47 men, 25 women; mean age, 57.49 years, SD 10.92) who had abdominal CT exams. Clinical information was recorded, including RLPS characteristics (histologic subtypes, grade, size), laboratory assessment (ALB, PALB, A/G, Hb, SCr), relapse-free survival, overall survival, and postoperative complications. The relationships between those variables and RFS and OS were analyzed using Cox proportional hazard models.
Results
There were 8 severe postoperative complications (Clavien-Dindo grade > 2). The Chi-square test showed sarcopenia was associated with severe postoperative complications (P = 0.011). In multivariate analysis, sarcopenia was not associated with relapse-free survival (P = 0.574) and overall survival (P = 0.578).
Conclusions
Sarcopenia predicts worse surgical complications but does not affect relapse-free survival and overall survival.
FORCE Risk Stratification Tool for Pediatric Cardiac Rehabilitation and Fitness Programs
Authors: Gauthier Naomi , Reynolds Lindsey , Curran Tracy , O’Neill Julie , Gauvreau Kimberlee , Alexander Mark E. 
Published: August 2022

Abstract
Risk stratification is required to set an exercise prescription for cardiac rehabilitation, but an optimal scheme for congenital heart disease (CHD) is unknown. We piloted a system based on hemodynamic rather than anatomic factors: Function, Oxygen level, Rhythm, Complex/Coronary anatomy, and Elevated load (FORCE). Feasibility, efficacy, and safety of the FORCE tool were evaluated.Methods: Patients <22 years old participating in the Cardiac Fitness Program at Boston Children’s Hospital between 02/2017 and 12/2021 were retrospectively analyzed. Assigned FORCE levels, anatomy, adverse events, fitness and exercise test data were collected.Results: Of 63 attempts at FORCE classification, 62 (98%) were successfully classified while one with restrictive cardiomyopathy was not. Thirty-nine (62%) were FORCE 1, 16 (25%) were FORCE 2, and 7 (11%) were FORCE 3. Almost half of FORCE 1 patients had simple or complex CHD and the majority of FORCE 2 patients had single ventricle CHD. FORCE 3 patients were more likely to have serious arrhythmias or cardiomyopathy than those in FORCE 1 or 2 (p<0.001). Postural orthostatic tachycardia syndrome patients appeared in FORCE 1 only. No adverse events occurred over 958 total sessions. The total number of fitness sessions/participant was similar across FORCE levels.Conclusion: It was feasible to risk stratify patients with CHD using a clinical FORCE tool. The tool was effective in categorizing patients and simple to use. No adverse events occurred with fitness training over nearly 1,000 exercise training sessions. Adding diastolic dysfunction to the original model may add utility.
GNR@PVA Electrodes acquired EEG Signals analysis
Authors: Prasad Anitha S prasad Anitha S , V Asha , Jayaram M N 
Published: August 2022

Abstract
The goal of work is to design cost-effective electromyography (EMG) signal acquisition system using GNP/FE electrode. EMG signal represent the muscle action potentials. Acquisition of EMG signal using Ag/AgCl and GNP/FE3O4@PVDF Surface Electrodes along with Arduino UNO. GNP/FE3O4@PVDF Electrodes with three different concentrations (1.5:1.5, 2:1, 3:0) are designed to acquire EMG signal for different age groups. EMG signal is Pre-processed by using wavelet transform. Performance of acquired EMG signal is measured with parameters like error percentage, correlation co-efficient, signal to noise ratio (SNR). The designed GNP/FE3O4@PVDF with 3:0 ratio shows good performance to acquire EMG for all age groups with minimal error and nominal SNR.
Tensor Decomposition for High-Resolution Images and Videos
Authors: Huang Huyunting , Liu Xiang , Tang Weitao , Zhang Tonglin , Yang Baijian 
Published: August 2022

Abstract
Tensor decompositions, including CANDECOMP/PARAFAC decomposition (CPD), Tucker decomposition (TKD), and tensor train decompositions (TTD), are extensions of singular value decomposition (SVD) for matrices. They are frameworks to decompose images or videos data into bases and coefficients. Due to recent developments in artificial intelligence (AI), tensor decomposition techniques are becoming increasingly important due to its compact representation, fast access , and easy reconstruction. However, tensor decompositions are still challenging in both computations and interpretations because CPD lacks orthogonality, TKD lacks sparsity, and TTD lacks both orthogonality and sparsity. To understand these issues, we evaluate their theoretical and practical limitations induced by the lack of orthogonality and sparsity in existing tensor decomposition methods. To overcome these limitations, a tensor decomposition method with both orthogo-nality and sparsity is proposed. Due to the two properties, the proposed method can be implemented by either a full decomposition or a partial decomposition version. Rather than the full decomposition version which always decomposes a given tensor into the sum of many rank-one tensors, the partial decomposition version only decomposes it into the sum of a number of outer products of lower-order tensors. This leads to the notation of eigen images, which reflects common important properties of images or videos with shared features. Eigen images are independent, meaning that they can be used to interpret the contents of images and videos. Experiment results show that the proposed method has small memory footprint and is much more efficient than existing tensor decomposition methods. Great advantages are demonstrated in conjunction with deep learning for object detection and recognition in high-resolution videos.
Mechanical properties and interface morphology of magnetic pulse-welded Al-Fe tubes with preset geometric features
Authors: Yu HaiPing , Dang Haiqing 
Published: August 2022

Abstract
A dissimilar metal tube joint fabricated by magnetic pulse welding (MPW) usually has uneven mechanical properties and an uneven morphology along the welding direction due to the small discontinuous matching range of the collision parameters. In this work, inclined, concave, and convex wall features were prefabricated on the target tube to improve the uniformity of the mechanical properties. The effects of the types of features and the prefabricated angle on the collision parameters, the axial distribution of the strength, and the interfacial morphology were investigated by simulations, shear tests, and microscopic observations, respectively. The results show that the collision parameters were increased with the increase of the prefabricated angle under the three types of features. Compared with the case without features, the increment of the collision parameters was found to be the greatest under the convex wall feature, and the smallest under the concave wall feature. With the increase of the prefabricated angle under the three types of features, the average shear strength tended to be reduced. When the prefabricated feature was the concave wall with a prefabricated angle of 5°, the quality of the joint was the best; it had an average shear strength of 46.46 MPa, an increase of 87%, and a low standard deviation of 4.96 MPa, a decrease of by 81%, as compared with that without geometric features. The transition layer was found to be the largest under the concave wall feature, and the maximum thickness decreased with the increase of the prefabricated angle.
Analysis on performance of Eco-friendly Engineered Cementitious Composite for construction and environmental Sustainability
Authors: Chowdary Muppalla Venkata Sai Surya Pratap , Asadi SS. 
Published: August 2022

Abstract
Engineered Cementitious Composite (ECC) is one of the versatile building components. The characteristics of materials and curing period are major factors that will influence the eco-friendly nature, and performance of the composite. In this experimental analysis, the impact of alkaline treated sisal fibres with different combinations of Polyvinyl alcohol (PVA) fibres (Mix-1 is 2% Sisal fibres, Mix-2 is 0.5% Sisal fibres + 1.5% PVA fibres) on the characteristics of Indian Zone II fine aggregates (50% river sand + 50% Manufactured sand) based ECC analyzed. For this, high fly ash to Cement dosage (f/c) of 1.4 is considered. These sisal fibres and f/c ratio are responsible for reduction in the disposal (or) environmental problems. The compressive strength of composite slightly improved from Mix-1 to Mix-2 at 28days with the decreased content of sisal fibres. But the split tensile and flexural characteristics highly increased by 8.33%, 5.45% from Mix-1 to Mix-2, respectively. These characteristics highly improved with the increased curing period (28days to 120days). The durability of the composite significantly influenced from 28days to 56days, but slightly improved with the decreased content of sisal fibres. To analyze these characteristics, SEM and XRD analysis are performed. Portlandite and quartz content was highly reduced (formation of C-S-H gel) from 28days to 56days due to hydration of unhydrated fly ash, fine aggregates, and other materials. The microstructure of both the mixes is densified with this gel. Mix-2 is more densified than Mix-1 due to the properties and arrangement of sisal fibres. These fibres are appropriately arranged in the partial replacement of PVA fibres compared to full dosage.
The relationship between Bisphenols exposure and intestinal flora: a systematic review and meta-analysis
Authors: Wang Tian , Sun Suju , Feng Yancheng , Guo Zhiwang , Wang Hao , Wang Liqin 
Published: August 2022

AbstractA growing number of studies have indicate that Bisphenols (BPs) have an effect on gut microbial community, including alter gut microbial diversity and composition. Due to limited sample size and some varied results, a review is needed to add credibility to the conclusion of BPs influence on gut microbial community. Literature search was implemented based on PubMed,Wed of Science, Science Direct, SinoMed, CNKI database from inception date to February 24,2022. Nineteen eligible articles (BPs exposure on rodent animal experiment studies) were included to our review and all literature’s references were traced back. Meta analysis were conducted to synthesis 5 alpha diversity index(observed species, chao, ace, Shannon, Simpson index), narrative synthesis approach was selected to synthesis composition of gut microbial in BPs group. Results suggest Simpson index significantly increase after BPs intervention. In subgroup analysis, Simpson significantly increase in low dose group( dosage ≦ 0.20mg/kg), observed species significantly decrease in long term group(duration > 5 weeks), chao index decrease in short term group and increase in long term group, chao and Shannon decrease in intestine sample group. To conclude, BPs exposure may decrease the abundance and diversity of gut microbial especially probiotic.