bluuebunny/crossref_metadata_2025_split huggingface dataset:
Along the Way to Gandhi’s Neighbour
Authors: Skaria Ajay 
Published: January 2025

Abstract
One of the key words in Gandhi’s vocabulary is swadeshi. Opposing the nationalist reading of the term, where swadeshi is exclusively economic in dimension with a focus primarily on consuming goods from one’s own country, he tries to make it a more broadly ethical practical practice of neighbourliness. Such neighbourliness, this chapter suggests, involves a certain political friendship. Neighbourliness as political friendship is quite different from intimate friendship: one does not choose one’s neighbours; one’s neighbours are those with whom one finds oneself in relations, and with whom there might often be intense disagreements. The chapter explores the tensions of neighbourliness as political friendship.
The Unbearable Lightness of Being Mahatma
Authors: Ramaswamy Sumathi 
Published: January 2025

Abstract
This chapter addresses the question: Is it possible to lead an engaged social and political life in our times and yet yearn to be immaterial and to pass on without a trace? It does so by considering the career and aspirations of Mohandas K. Gandhi (a.k.a. ‘the Mahatma’) but from the largely understudied perspective of the material lifeworld with which he was entangled. Using a material culture approach, I explore the heavy burden of being Mahatma by detailing the paradoxical accumulation of stuff around Gandhi, a man who committed himself to dispossessing himself of all but what he deemed necessary, following his stated principle of possessing non-possession (aparigraha). His paltry possessions in turn get overburdened as they come to serve as material proxies for his corporeal presence, especially in the aftermath of his death, in artworks and memorializing activities.
Political Careers and Prime-Ministerial Performance
Authors: Grotz Florian , Berz Jan , Kroeber Corinna , Kukec Marko 
Published: January 2025

Abstract
This chapter explores how the political experience of prime ministers (PMs) in post-communist Central and Eastern Europe affects their performance in office. It argues that previous political positions help PMs to develop individual assets and enable them to perform more successfully as heads of government. The analyses reveal that previous party leadership experience is the strongest predictor of successful performance as a PM. PMs who were previously party leaders have a particular capacity to secure the support of their own party, to settle cabinet conflicts, and to shape government policies. Lastly, the chapter shows that PMs’ previous participation in communist parliaments and executives also has positive effects on their performance, in particular their ability to shape government policies.
How alcohol label design influences attention among young adults: evidence from an eye-tracking study
Authors: Lacoste-Badie Sophie , Droulers Olivier 
Published: January 2025

Abstract

Aims
Exposure to alcohol marketing is associated with higher alcohol consumption. In recent years, a growing number of modern labels have appeared on alcohol bottles. Unlike traditional labels that typically convey factual details about a product, such as product type, quality, origin, and brewery creation date, modern labels are designed to create an imaginary, often quirky universe that is disconnected from the product itself. These new labels are used by alcohol manufacturers to increasingly appeal to the younger generation, acknowledged to exhibit heightened sensitivity to alcohol marketing. We sought to explore the influence of the design of modern alcohol labels on attention and choice among young adults.

Methods
The data were collected from a within-subjects experiment using realistic stimuli, with participants exposed to two label design conditions (modern vs. traditional). The study combined an eye-tracking method with declarative measures.

Results
The participants made more fixations and revisits and looked more quickly at the modern labels and for longer compared to traditional labels. In addition, beer bottles with modern labels were selected more often than those with traditional labels.

Conclusion
As the study demonstrates the strong influence of alcohol labeling design on young consumers’ attention and product choices, we believe that there is a need to introduce more stringent regulations on alcohol packaging and labeling, an aspect that has thus far received little attention from public authorities.
The FGF14 GAA repeat expansion is a major cause of ataxia in the Cypriot population
Authors: Livanos Ioannis , Votsi Christina , Michailidou Kyriaki , Pellerin David , Brais Bernard , Zuchner Stephan , Pantzaris Marios , Kleopa Kleopas A , Zamba Papanicolaou Eleni , Christodoulou Kyproula 
Published: January 2025

Abstract
Dominantly inherited intronic GAA repeat expansions in the fibroblast growth factor 14 gene have recently been shown to cause spinocerebellar ataxia 27B. Currently, the pathogenic threshold of (GAA)≥300 repeat units is considered highly penetrant, while (GAA)250–299 is likely pathogenic with reduced penetrance. This study investigated the frequency of the GAA repeat expansion and the phenotypic profile in a Cypriot cohort with unresolved late-onset cerebellar ataxia. We analysed this trinucleotide repeat in 155 patients with late-onset cerebellar ataxia and 227 non-neurological disease controls. The repeat locus was examined by long-range PCR followed by fragment analysis using capillary electrophoresis, agarose gel electrophoresis and automated electrophoresis. A comprehensive comparison of all three electrophoresis techniques was conducted. Additionally, bidirectional repeat-primed PCRs and Sanger sequencing were carried out to confirm the absence of any interruptions or non-GAA motifs in the expanded alleles. The (GAA)≥250 repeat expansion was present in 12 (7.7%) patients. The average age at disease onset was 60 ± 13.5 years. The earliest age of onset was observed in a patient with a (GAA)287 repeat expansion, with ataxia symptoms appearing at 25 years of age. All patients with spinocerebellar ataxia 27B displayed symptoms of gait and appendicular ataxia. Nystagmus was observed in 41.7% of the patients, while 58.3% exhibited dysarthria. Our findings indicate that spinocerebellar ataxia 27B represents the predominant aetiology of autosomal dominant cerebellar ataxia in the Cypriot population, as this is the first dominant repeat expansion ataxia type detected in this population. Given our results and existing research, we propose including fibroblast growth factor 14 GAA repeat expansion testing as a first-tier genetic diagnostic approach for patients with late-onset cerebellar ataxia.
Identify biological Alzheimer’s disease using a novel nucleic acid–linked protein immunoassay
Authors: Wang Yi-Ting , Ashton Nicholas J , Therriault Joseph , Benedet Andréa L , Macedo Arthur C , Pola Ilaria , Aumont Etienne , Di Molfetta Guglielmo , Fernandez-Arias Jaime , Tan Kubra , Rahmouni Nesrine , Servaes Stijn Johannes G , Isaacson Richard , Chan Tevy , Hosseini Seyyed Ali , Tissot Cécile , Mathotaarachchi Sulantha , Stevenson Jenna , Lussier Firoza Z , Pascoal Tharick A , Gauthier Serge , Blennow Kaj , Zetterberg Henrik , Rosa-Neto Pedro 
Published: January 2025

Abstract
Blood-based biomarkers have been revolutionizing the detection, diagnosis and screening of Alzheimer’s disease. Specifically, phosphorylated-tau variants (p-tau181, p-tau217 and p-tau231) are promising biomarkers for identifying Alzheimer’s disease pathology. Antibody-based assays such as single molecule arrays immunoassays are powerful tools to investigate pathological changes indicated by blood-based biomarkers and have been studied extensively in the Alzheimer’s disease research field. A novel proteomic technology—NUcleic acid Linked Immuno-Sandwich Assay (NULISA)—was developed to improve the sensitivity of traditional proximity ligation assays and offer a comprehensive outlook for 120 protein biomarkers in neurodegenerative diseases. Due to the relative novelty of the NULISA technology in quantifying Alzheimer’s disease biomarkers, validation through comparisons with more established methods is required. The main objective of the current study was to determine the capability of p-tau variants quantified using NULISA for identifying abnormal amyloid-β and tau pathology. We assessed 397 participants [mean (standard deviation) age, 64.8 (15.7) years; 244 females (61.5%) and 153 males (38.5%)] from the Translational Biomarkers in Aging and Dementia (TRIAD) cohort where participants had plasma measurements of p-tau181, p-tau217 and p-tau231 from NULISA and single molecule arrays immunoassays. Participants also underwent neuroimaging assessments, including structural MRI, amyloid-PET and tau-PET. Our findings suggest an excellent agreement between plasma p-tau variants quantified using NULISA and single molecule arrays immunoassays. Plasma p-tau217 measured with NULISA shows excellent discriminative accuracy for abnormal amyloid-PET (area under the receiver operating characteristic curve = 0.918, 95% confidence interval = 0.883 to 0.953, P &lt; 0.0001) and tau-PET (area under the receiver operating characteristic curve = 0.939; 95% confidence interval = 0.909 to 0.969, P &lt; 0.0001). It also presents the capability for differentiating tau-PET staging. Validation of the NULISA-measured plasma biomarkers adds to the current analytical methods for Alzheimer’s disease diagnosis, screening and staging and could potentially expedite the development of a blood-based biomarker panel.
Advancements in hydrogen gas leakage detection sensor technologies and safety measures
Authors: Menon Shyam Kumar , Kumar Adesh , Mondal Surajit 
Published: January 2025

Abstract
Hydrogen is hailed as a plentiful and clean energy source, which holds promise as a substitute for fossil fuels, particularly when produced through solar water splitting. However, its volatile and explosive nature necessitates stringent safety measures throughout its production, transportation, and utilization. This study analyzes hydrogen gas leakage detection by using various sensors such as ultrasonic, electrochemical, metal oxide (MOX), catalytic, and fiber Bragg grating sensors. Various sensor technologies are developed for hydrogen leak detection, and each offers unique advantages and challenges. Fiber optic sensors, leveraging changes in light interference, provide explosion resistance and durability, while ultrasonic sensors detect leaks through sound wave analysis, albeit with limited commercial application in hydrogen environments. Schlieren imaging offers real-time visualization of hydrogen behavior, predominantly in laboratory settings. Electrochemical sensors enable reliable detection through electrochemical interactions, while MOX sensors exhibit sensitivity and ease of manufacturing, albeit with challenges related to cross-sensitivity and response times. Catalytic gas sensors and thermal conductivity sensors offer alternative detection methods, with the former catalyzing hydrogen combustion for detection and the latter measuring temperature differentials upon exposure to hydrogen. The analysis of hydrogen leakage incidents highlights the importance of robust safety measures in hydrogen infrastructure and facilities. The integration of innovative sensing technologies with automated shutdown systems and robust materials has enhanced the reliability and efficiency of leak detection systems. Continued research and cooperation are essential to address residual challenges and further enhance the safety of hydrogen utilization in various industrial sectors.
Influenza Vaccine Effectiveness Against Medically Attended Outpatients Illness, United States, 2023–2024 Season
Authors: Chung Jessie R , Price Ashley M , Zimmerman Richard K , Moehling Geffel Krissy , House Stacey L , Curley Tara , Wernli Karen J , Phillips C Hallie , Martin Emily T , Vaughn Ivana A , Murugan Vel , Scotch Matthew , Saade Elie A , Faryar Kiran A , Gaglani Manjusha , Ramm Jason D , Williams Olivia L , Walter Emmanuel B , Kirby Marie K , Keong Lisa M , Kondor Rebecca , Ellington Sascha R , Flannery Brendan 
Published: January 2025

Abstract

Background
The 2023–2024 US influenza season was characterized by a predominance of A(H1N1)pdm09 virus circulation with cocirculation of A(H3N2) and B/Victoria viruses. We estimated vaccine effectiveness (VE) in the United States against mild-to-moderate medically attended influenza illness in the 2023–2024 season.

Methods
We enrolled outpatients aged ≥8 months with acute respiratory illness in 7 states. Respiratory specimens were tested for influenza type/subtype by reverse-transcriptase polymerase chain reaction. Influenza VE was estimated with a test-negative design comparing odds of testing positive for influenza among vaccinated versus unvaccinated participants. We estimated VE by virus subtype/lineage and A(H1N1)pdm09 genetic subclades.

Results
Among 6629 enrolled patients, 1780 (27%) tested positive for influenza, including 806 with A(H1N1)pdm09, 567 with B/Victoria, and 328 with A(H3N2). VE against any influenza illness was 44% (95% confidence interval, 36%–51%): 29% (15%–41%) against influenza A(H1N1)pdm09, 74% (65%–81%) against B/Victoria, and 30% (8%–47%) against A(H3N2). Statistically significant protection against any influenza was found for all age groups except adults aged 50–64 years. Lack of protection in this age group was specific to influenza A–associated illness. We observed differences in VE by birth cohort and A(H1N1)pdm09 virus genetic subclade.

Conclusions
Vaccination reduced outpatient medically attended influenza overall by 44% and provided protection overall against circulating influenza A and B viruses. Serologic studies would help inform differences observed by age groups.
Cardioprotection exerted by intravenous statin at index myocardial infarction event attenuates cardiac damage upon recurrent infarction
Authors: Vilahur Gemma , Ben-Aicha Soumaya , Gutiérrez Manuel , Radike Monika , Mendieta Guiomar , Ramos Lisaidy , Alcover Sebastia , Casani Laura , Arderiu Gemma , Padró Teresa , Borrell-Pages María , Badimon Lina 
Published: January 2025

Abstract

Aims
Recurrent acute myocardial infarction (RE-AMI) is a frequent complication after STEMI, and its association with stent thrombosis can be life-threatening. Intravenous atorvastatin (IV-atorva) administration during AMI has been shown to limit infarct size and adverse cardiac remodelling. We determined by cardiac magnetic resonance (CMR) whether the cardioprotection exerted by IV-atorva at the index AMI event translates into a better prognosis upon RE-AMI in dyslipidemic pigs.

Methods and results
Hypercholesterolemic pigs underwent a first AMI (90-min coronary balloon occlusion). During ongoing ischaemia, animals received IV-atorva or vehicle. Forty days later, animals underwent RE-AMI and were sacrificed on Day 43. All animals remained on p.o. atorvastatin and a high-cholesterol diet from the first AMI until sacrifice. Serial CMR analysis was performed on Day 3 post-AMI, prior- (Day 40) and post-RE-AMI (Day 43). No differences were detected in oedema formation in both animal groups during AMI and RE-AMI. Gadolinium DE-CMR revealed smaller infarcts in IV-atorva-treated animals at index event at 3 and 40 days post-AMI compared to vehicle-administered pigs (P &lt; 0.05). CMR analyses post-RE-AMI revealed smaller infarcts in the animals treated with IV-atorva at index event than in the vehicle-administered pigs. These IV-atorva at index event benefits were associated with higher left ventricular (LV) ejection fraction and normal LV wall motion in the jeopardized myocardium at RE-AMI (P &lt; 0.05 vs. vehicle). The scar region of RE-AMI of animals treated with IV-atorva at index event showed reduced cardiac inflammatory infiltrate, apoptosis and senescence activation, and increased reparative fibrosis and neovessel formation vs. vehicle-administered pigs. Animals treated with IV-atorva at index event also showed lower C-reactive protein and higher interleukin-10 plasma levels in the setting of RE-AMI.

Conclusion
The cardioprotection afforded by IV-atorva administration during an index-AMI event shows a legacy effect attenuating myocardial damage and preserving cardiac contractile function upon RE-AMI. The potential benefits of this intravenous approach should be tested in the clinical setting.
Anatomy vs. shunt fraction: haemodynamic consequences in atrial septal defects and partial anomalous pulmonary venous connection—a comprehensive CMR study
Authors: Jacquemyn Xander , Van De Bruaene Alexander , Budts Werner , Dresselaers Tom , Bogaert Jan 
Published: January 2025

Abstract

Aims
Atrial septal defect (ASD) and partial abnormal pulmonary venous connection (PAPVC) are non-cyanotic congenital heart defects (CHDs) that produce a left-to-right shunt. This single-centre retrospective study aimed to assess the haemodynamic impact of isolated ASD, isolated PAPVC, and ASD-associated PAPVC using cardiovascular magnetic resonance (CMR).

Methods and results
From our CMR registry (2002–24), 110 patients were included: isolated ASD (n = 64), isolated PAPVC (n = 18), and ASD-associated PAPVC (n = 28, mostly sinus venosus septal defects). CMR included geometric assessment of the cardiac chambers and great vessels, assessment of ventricular function, and flow patterns through the systemic (Qs) and pulmonary circulation (Qp). Patients were compared with a 40 control subjects with normal CMR findings. Significant differences were observed between controls, isolated ASD, isolated PAPVC, and ASD-associated PAPVC groups in left ventricular end-diastolic volumes (EDVs) indexed to body surface area (BSA) [80 mL/m2 (75–90) vs. 71 mL/m2 (57–79) vs. 71 mL/m2 (63–80) vs. 64 mL/m2 [57–72], P &lt; 0.001], right ventricular EDVs/BSA [82 mL/m2 (74–88) vs. 110 mL/m2 (101–127) vs. 150 mL/m2 (120–165) vs. 154 mL/m2 (128–181), P &lt; 0.001)] and Qp/Qs ratio [0.99 (0.95–1.01) vs. 1.49 (1.34–1.67) vs. 1.96 (1.55–2.40) vs. 2.15 (1.81–2.64), P &lt; 0.001]. No significant modulating factors were found for cardiac chambers or great vessels geometry, ventricular function, or flow patterns between the patient groups.

Conclusion
Despite phenotypic differences, no specific anatomical influences were found, suggesting that outcomes in isolated ASD, isolated PAPVC, and ASD-associated PAPVC are mainly driven by the degree of shunting.
A pairwise and network meta-analysis of anti-inflammatory strategies after myocardial infarction: the TITIAN study
Authors: Laudani Claudio , Occhipinti Giovanni , Greco Antonio , Giacoppo Daniele , Spagnolo Marco , Capodanno Davide 
Published: January 2025

Abstract

Background and aims
Multiple anti-inflammatory drugs have been tested for secondary prevention after myocardial infarction (MI), giving mixed results and questioning the efficacy of anti-inflammatory therapy. No head-to-head comparisons between anti-inflammatory drugs have been performed. This study aimed to compare the efficacy and safety of anti-inflammatory drugs for secondary prevention after MI and the relative merits of specific drugs and administration strategies.

Methods and results
Randomized trials of anti-inflammatory therapy for secondary prevention after MI were identified. Primary efficacy and safety endpoints were trial-defined major adverse cardiovascular events (MACEs) and serious adverse events. Secondary endpoints included all-cause death, individual MACE components, serious infection, cancer, and gastrointestinal adverse events. Pairwise meta-analyses were conducted with interaction analyses for drug type and timing of administration, in addition to network meta-analyses. Multiple sensitivity and meta-regression analyses were conducted to explore potential heterogeneity sources. Twenty-eight studies, involving 44 406 patients with a mean follow-up of 11 months, were included. Anti-inflammatory therapy reduced the incidence of MACEs [incidence rate ratio (IRR): 0.92; 95% confidence interval (CI): 0.86–0.98] compared to control, without increasing serious adverse events. However, it was associated with a higher incidence of gastrointestinal adverse events (IRR: 1.21; 95% CI: 1.07–1.36). No significant interaction was observed between the effects of anti-inflammatory therapy on MACE and the timing of administration.

Conclusion
In secondary prevention for MI, anti-inflammatory therapy significantly reduces MACE without increasing serious adverse events, but it is associated with an increased risk of gastrointestinal adverse events.
Monitoring and assessment of population, reproductive, and health effects in colonial waterbirds breeding at contaminated Great Lakes sites in Michigan
Authors: Grasman Keith A , Annis Mandy , Eakin Carly , Moore Jeremy , Williams Lisa L 
Published: January 2025

Abstract
Immunological, reproductive, and population endpoints were assessed in fish-eating birds during 2010–2019 in the Saginaw River and Bay and River Raisin Areas of Concern (AOCs) and Grand Traverse Bay, which are ecosystems historically contaminated with polychlorinated biphenyls, dibenzo-p-dioxins, and dibenzofurans. Reference sites were in the lower St. Marys River (herring gulls and Caspian terns), eastern Lake Superior (terns), and eastern Lake Huron (black-crowned night herons). Relative risk ratios for embryonic nonviability (from both infertility and mortality) in gull embryos were 2–3-fold higher than the reference site in both AOCs and Grand Traverse Bay. Twelve of 13 deformed embryos and chicks (e.g., crossed bills and gastroschisis) were observed at the contaminated sites. Productivity of 4-week-old tern chicks in Saginaw Bay was 35% lower than that at reference sites. In the River Raisin AOC, productivity of 4-week gull chicks was poor in 7 of 10 years. Numbers of breeding herring gulls decreased significantly in the River Raisin AOC, and breeding Caspian terns, a state-threatened species, declined in the Saginaw River and Bay AOC. The mean T cell-dependent phytohemagglutinin skin response was suppressed 50%–56% in gull chicks in both AOCs and Grand Traverse Bay, and 49% in terns and 33% in herons in Saginaw Bay. Antibody responses in gull chicks in the River Raisin AOC and Grand Traverse Bay were 1.6–2-fold lower than reference. Time trend analyses showed no significant improvements in reproductive and immune endpoints in either AOC or Grand Traverse Bay over the study period. Embryonic death increased with time in gulls in the lower Saginaw Bay, and antibody responses decreased in terns in the outer Saginaw Bay.