bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longibrachiamide A, a 20‐Residue Peptaibol Isolated from Trichoderma longibrachiatum Rifai DMG‐3‐1‐1
Authors: Zhang Shu‐Hua , Yue Xian‐Lin , Zhao Xue , Tang Jing , Yang Yu , Xu Rui , Ma Hao , Zhu Shuai‐Ming , Luo Fu‐Yao , Zhang Qin , Zhang Guo‐Gang , Li Chang‐Wei 
Published: May 2022

AbstractLongibrachiamide A (1), a new 20‐residue peptaibol, along with three known ones (2–4), were isolated from the fungus Trichoderma longibrachiatum Rifai DMG‐3‐1‐1, isolated from a mushroom Clitocybe nebularis (Batsch) P. Kumm, which was collected from coniferous forest of northeast China in our previous work. The structure of longibrachiamide A (1) was determined by its NMR and ESI‐MS/MS data, the absolute configuration of 1 was further determined by Marfey's analyses. And the complete NMR data of 2–4 were also reported for the first time. The similar CD spectra of 1–4 showed that they all had mixed 310‐/α‐helical conformations. Compounds 1–4 showed strong cytotoxicities against BV2, A549 and MCF‐7 cells, and also showed moderate inhibitory effects against the tested Gram‐positive bacteria, including MRSA T144 and VRE‐10.
Physico‐Chemical Properties and Principal Component Analysis of Biobased Thermosets Developed with Different Batches of Industrial Humins
Authors: Dinu Roxana , Gaysinski Marc , de Jong Ed , Mija Alice 
Published: May 2022

AbstractHumins have already shown their potential as thermosetting resins to produce crosslinked networks and composites, with a large variety of properties depending on the used macromolecular approach. Our group has shown that a very interesting class of materials with tunable flexibility can be made by humins co‐polymerization with glycerol diglycidyl ether (GDE). To create a clearer picture on structure‐reactivity‐properties‐application interdependent relationship, a principal component analysis (PCA) was applied on several humins batches. The PCA allowed to obtain a clear discrimination between the humins/GDE resins samples in 3 groups which correlate very well with the results of copolymerization reactivity (DSC) and thermosets properties: crosslink density, thermal stability, tan δ, Shore D hardness values, etc.
Diversification of circulating and tumor‐infiltrating plasmacytoid DCs towards the P3 (CD80+ PDL1−)‐pDC subset negatively correlated with clinical outcomes in melanoma patients
Authors: Sosa Cuevas Eleonora , Bendriss‐Vermare Nathalie , Mouret Stephane , De Fraipont Florence , Charles Julie , Valladeau‐Guilemond Jenny , Chaperot Laurence , Aspord Caroline 
Published: May 2022

AbstractObjectivesPlasmacytoid DCs (pDCs) play a critical yet enigmatic role in antitumor immunity through their pleiotropic immunomodulatory functions. Despite proof of pDC diversity in several physiological or pathological contexts, pDCs have been studied as a whole population so far in cancer. The assessment of individual pDC subsets is needed to fully grasp their involvement in cancer immunity, especially in melanoma where pDC subsets are largely unknown and remain to be uncovered.MethodsWe explored for the first time the features of diverse circulating and tumor‐infiltrating pDC subsets in melanoma patients using multi‐parametric flow cytometry, and assessed their clinical relevance. Based on CD80, PDL1, CD2, LAG3 and Axl markers, we provided an integrated overview of the frequency, basal activation status and functional features of pDC subsets in melanoma patients together with their relationship to clinical outcome.ResultsStrikingly, we demonstrated that P3‐pDCs (CD80+PDL1−) accumulated within the tumor of melanoma patients and negatively correlated with clinical outcomes. The basal activation status, diversification towards P1‐/P2‐/P3‐pDCs and functionality of several pDC subsets upon TLR7/TLR9 triggering were perturbed in melanoma patients, and were differentially linked to clinical outcome.ConclusionOur study shed light for the first time on the phenotypic and functional heterogeneity of pDCs in the blood and tumor of melanoma patients and their potential involvement in shaping clinical outcomes. Such novelty brightens our understanding of pDC complexity, and prompts the further deciphering of pDCs’ features to better apprehend and exploit these potent immune players. It highlights the importance of considering pDC diversity when developing pDC‐based therapeutic strategies to ensure optimal clinical success.
The mediating role of self‐criticism, experiential avoidance and negative urgency on the relationship between ED‐related symptoms and difficulties in emotion regulation
Authors: Rodrigues Tânia F. , Ramos Rita , Vaz Ana Rita , Brandão Isabel Marques , Fernandez‐Aranda Fernando , Machado Paulo P. P. 
Published: May 2022

AbstractObjectiveDifficulties in emotion regulation are thought to play a transdiagnostic role across eating disorders (ED). In the current study, we explored with a path analysis the mediating role of self‐criticism, experiential avoidance and negative urgency on the relationship between ED‐related symptoms and dimensions of difficulties in emotion regulation.MethodParticipants were 103 female outpatients recruited at a Portuguese ED hospital unit, diagnosed with an ED, aged 14–60 years old (M = 28.0, SD = 10.5), body mass index (BMI) ranging from 11.72 to 39.44 (M = 20.1, SD = 5.4).ResultsThe path analysis resulted in a model with an adequate fit to the data (SRMR = 0.05; RMSEA = 0.07 [0.00, 0.12], PCLOSE = 0.269; TLI = 0.97; IFI = 0.99; GFI = 0.95). A final model in which the relationship between ED‐related symptoms and dimensions of difficulties in emotion regulation was mediated by self‐criticism, experiential avoidance and negative urgency, accounted for a variance of 71% for strategies, 57% for non‐acceptance, 62% for impulses, 56% for goals and 20% for clarity.ConclusionResults suggest that self‐criticism, experiential avoidance and negative urgency, combined, are relevant in the relationship between ED‐related symptoms and difficulties in emotion regulation. ED treatment and emotion regulation skills may be enhanced through the inclusion of specific components that target self‐criticism, experiential avoidance and negative urgency, as they become prominent during the therapeutic process.
Can Chemical Toxicity in Saltwater Be Predicted from Toxicity in Freshwater? A Comprehensive Evaluation Using Species Sensitivity Distributions
Authors: Yanagihara Miina , Hiki Kyoshiro , Iwasaki Yuichi 
Published: May 2022

Abstract
Species sensitivity distributions (SSDs) play an important role in ecological risk assessment. Estimating SSDs requires toxicity data for many species, but reports on saltwater species are often limited compared to freshwater species. This limitation can constrain informed management of saltwater quality for the protection of marine ecosystems. We investigated the relationships between the parameters (i.e., mean and standard deviation [SD]) of freshwater and saltwater log-normal SSDs to determine how accurately saltwater toxicity could be estimated from freshwater toxicity test data. We estimated freshwater and saltwater SSDs for 104 chemicals with reported acute toxicity data for five or more species and compared their means, SDs, and hazardous concentrations for 5% of the species (HC5) derived from the acute SSDs. Standard major axis regression analyses generally showed that log–log relationships between freshwater and saltwater SSD means, SDs, and HC5 values were nearly 1:1. In addition, the ratios of freshwater-to-saltwater SSD means and HC5 values for most of the 104 chemicals fell within the range 0.1–10. Although such a strong correlation was not observed for SSD SDs (r2 &lt; 0.5), differences between freshwater and saltwater SSD SDs were relatively small. These results indicate that saltwater acute SSDs can be reasonably estimated using freshwater acute SSDs. Because the differences of the means and SDs between freshwater and saltwater SSDs were larger when the number of test species used for SSD estimation was lower (i.e., five to seven species in the present study), obtaining toxicity data for an adequate number of species will be key to better approximation of a saltwater acute SSD from a freshwater acute SSD for a given chemical. Environ Toxicol Chem 2022;41:2021–2027. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Abstract
Prediction of saltwater species sensitivity distribution (SSD) from freshwater SSD.
i‐WABA: An efficient wavelengths arrangement and bandwidth allocationWDMAprotocol for passive optical intra‐rack data center networks
Authors: Baziana P. A. 
Published: May 2022

AbstractIn this article, we effectively handle the continuously growing traffic within data centers (DCs) and we focus on the intra‐rack communication. We propose a passive optical intra‐rack DC network (DCN) that uses a set of wavelengths for the data intra‐rack communication and a separate control wavelength for pre‐transmission coordination. We introduce a distributed access control scheme, named intra‐rack wavelengths arrangement and bandwidth allocation (i‐WABA) protocol, to effectively arrange the data wavelengths into groups and efficiently allocate them among the servers for transmission, avoiding synchronization complexity. The proposed i‐WABA protocol ensures the collisions‐free transmission over the data wavelengths and at destination achieving high performance, scalability, and reliability. In opposition to the majority of the state‐of‐the‐art intra‐rack MAC protocols that adopt synchronous transmission requiring strict time compliance, the proposed i‐WABA protocol is unslotted providing simple and reliable access control even under high data rates. Moreover, unlike other studies that assume that the control communication is performed over an Ethernet link, the proposed intra‐rack DCN considers that it is performed in the optical domain, ensuring its effective parallel operation to the data communication. The throughput improvement is extensively studied and it is proven to be an increasing function of the number of data wavelengths groups. Finally, the proposed intra‐rack DCN along with the proposed i‐WABA protocol is compared with other state‐of‐the‐art intra‐rack DCNs in terms of throughput, power consumption, and cost, while it is proven to be a performance, energy, and cost efficient DCN solution.
Soluble factors and suppressive monocytes can predict early development of sepsis in acute‐on‐chronic liver failure
Authors: Yadav Pushpa , Trehanpati Nirupama , Maiwall Rakhi , Sehgal Rashi , Singh Ravinder , Islam Mojahidul , Jagdish Rakesh Kumar , Vijayaraghavan Rajan , Maheshwari Deepanshu , Bhat Sadam , Kale Pratibha , Kumar Anupam , Baweja Sukriti , Kumar Guresh , Ramakrishna Gayatri , Sarin Shiv K. 
Published: May 2022

Abstract
Patients with acute‐on‐chronic liver failure (ACLF) have a high probability of developing systemic inflammation and sepsis due to immune dysregulation. Fifty‐nine patients with ACLF (12 without and 19 with systemic inflammation, and 28 with sepsis) were serially monitored for clinical and immunological changes at baseline, 6 hours, 24 hours, day 3, and day 7 following hospitalization. Ten healthy controls were also included. At all time points, soluble plasma factors and monocyte functions were studied. Patients with ACLF and systemic inflammation showed higher interleukin (IL)–6, vascular endothelial growth factor‐a, monocyte chemoattractant protein 1, and macrophage inflammatory protein 1β than patients with no systemic inflammation. Patients with ACLF with sepsis had raised (p < 0.001) levels of IL‐1Ra, IL‐18, and triggering receptor expressed on myeloid cells 1 (TREM1) compared to patients with ACLF‐systemic inflammation. Five of the 19 (26.3%) patients with systemic inflammation developed sepsis within 48–72 hours with a rapid rise in plasma levels of IL‐1Ra (1203–35,000 pg/ml), IL‐18 (48–114 pg/ml), and TREM1 (1273–4865 pg/ml). Monocytes of patients with ACLF with systemic inflammation and sepsis showed reduced human leukocyte antigen–DR but increased programmed death ligand 1 (PD‐L1) and T‐cell immunoglobulin and mucin domain‐containing protein 3 (TIM3) (p < 0.04) expression with increased ETosis by monocytes at baseline and until day 7. Conclusion: High and rising levels of plasma IL‐1Ra, IL‐18, TREM1 soluble factors, and increased suppressive monocytes (PDL1+ve, TIM3+ve) at baseline can stratify patients with ACLF at high risk of developing sepsis within 48–72 hours of hospitalization.
Evaluation of supply sustainability of vaccine alternatives with multi‐criteria decision‐making methods
Authors: Yazıcı Emre , Üner Sabire İrem , Demir Aslı , Dinler Sevda , Alakaş Hacı Mehmet 
Published: May 2022

AbstractBackground: The treatment of the COVID‐19 epidemic, whose contagious features are changing day by day, is the most current problem today throughout of the world. In order to be protected from COVID‐19 and reduce its spread, it is of great importance to follow the rules such as mask, distance and hygiene. In addition, one of the most important ways to prevent the epidemic is to develop population immunity. The most important tool in having population immunity is vaccination.Aims: During the COVID‐19 pandemic, there have been problems in the supply process of many products in food and health sectors. Vaccine is also one of the most difficult tools to supply. In this context, the study focused on the selection of the vaccine provided by the countries within the scope of population vaccination studies.Materials & Methods: At the selection point, the criteria affecting the purchasing process were determined and the weights of these criteria were calculated using the AHP method. Then, the criteria weights obtained were used to rank the alternatives in an integrated manner in the Preference Ranking Organization Method for Enrichment of Evaluations (PROMETHEE) and Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) methods. The results of both methods were analyzed comparatively.Results: According to the TOPSIS Method, the first alternative is Oxford‐AstraZeneca for all countries, and BioNTech for all countries in the PROMETHEE method.Discussion: The vaccine storage conditions criterion is the most important in vaccine supply. The criterion with the lowest importance is Supply Cost. It has been revealed that cost elements remain in the background under pandemic conditions.Conclusion: Vaccine evaluation studies and policy recommendations are presented by considering public health in the selection of vaccine alternatives.
Perceptions of motivational interviewing in genetic counseling practice and training
Authors: Spector Ashley , Ash Erin , Garland Beth , McLaughlin Robert , Ritenour Adasia , Gonynor Caroline , Riconda Daniel 
Published: May 2022

AbstractMotivational interviewing (MI) is a counseling approach that allows a provider to engage in a dialog with patients to evoke motivation for health behavior change or decision‐making. MI is a relatively recent addition to the curricula of genetic counseling programs, and recent research has demonstrated its utility in genetic counseling practice. However, the perspectives of genetic counselors trained in MI have yet to be studied with the intent of illuminating how it is applied in practice or what should be emphasized in training. This qualitative study interviewed fifteen genetic counselors from various practice areas who have had training in MI. The interviews focused on how MI is being used in practice, and the strengths and weaknesses of their MI training. Five themes were identified through inductive qualitative analysis: (a) utility of MI in genetic counseling practice, (b) value of MI in genetic counseling training, (c) barriers to implementing MI in genetic counseling practice, (d) barriers to training genetic counselors in MI, and (e) timing of MI training. The perspectives discovered from this study can help inform genetic counseling educators who wish to include MI in their curriculum. In addition for those programs that already include MI, these results serve as a guide for the development of training role‐plays and/or standardized patient encounter scenarios.
Electrostatic Adsorption Behaviors of Charged Polymer‐Tethered Nanoparticles on Oppositely Charged Surfaces
Authors: Shen Xiaoxue , Zhang Yan , He Huibin , Yi Chenglin , Dong Wenhao , Ye Shunsheng , Zheng Di , Tao Jing , Wu Qi , Duan Xiaozheng , Nie Zhihong 
Published: May 2022

AbstractPolymer‐grafted hairy nanoparticles (HNPs) that combine the unique properties of inorganic nanoparticles (NPs) and polymers are attractive building blocks for the layer‐by‐layer assembly of functional hybrid materials, but the adsorption behaviors of HNPs on substrates remain unclear. This article describes a systematic study on the adsorption behaviors of charged polymer‐grafted HNPs on oppositely charged substrates in different solvent media via a combination of experiments and simulations. It is shown in simulations that the adsorption process of HNPs is associated with the release of counterions around charged polymers on HNPs, thus resulting in a higher energy barrier of NP adsorption than bare NPs without charged polymer tethers. This energy barrier decreases with decreasing the dielectricity of solvents or ionization degree of grafted polymers or increasing ionic strength of the solution. Furthermore, the theoretical prediction is confirmed in experiments by using a model system of poly(acrylic acid)‐grafted silica NPs and poly(diallyldimethylammonium chloride)‐modified wafers. The work provides guidance for the electrostatic assembly of HNPs into functional hybrid composites with applications in membranes, optical devices, and biomedicines.
Massively parallel sequencing uncovered disease‐associated variant spectra of glucose‐6‐phosphate dehydrogenase deficiency, phenylketonuria and galactosemia in Vietnamese pregnant women
Authors: Nguyen Tat‐Thanh , Le Quang‐Thanh , Hoang Diem‐Tuyet Thi , Du Nguyen Huu , Ha Thi Minh Thi , Nguyen My‐Nhi Ba , Ta Thanh‐Thuy Thi , Tran Nhat Thang , Trinh Thu Huong Nhat , Doan Kim Phuong Thi , Lam Duc Tam , Tran Son Tra Thi , Nguyen Thanh Xuan , Le Hong‐Thinh , Ha Van Tuan , Nguyen Manh Hoan , Le Ba‐Liem Kim , Duong My Linh , Pham Trung Ha , Tran Anh Tuan , Phan Xuan Lan Thi , Huynh Thanh Liem , Nguyen Lan‐Phuong Thi , Vo Thanh Binh , Le Duy‐Khang Nguyen , Tran Ngoc Nhu Thi , Tran Quynh Nhu Thi , Van Yen‐Linh Thi , Huynh Bich‐Ngoc Thi , Nguyen Thanh‐Phương Thi , Dao Trang Thi , Nguyen Lan Phuong Thi , Vo Truong‐Giang , Do Thanh‐Thuy Thi , Truong Dinh‐Kiet , Tang Hung Sang , Phan Minh‐Duy , Nguyen Hoai‐Nghia , Giang Hoa 
Published: May 2022

AbstractBackgroundSeveral inherited metabolic diseases are underreported in Vietnam, namely glucose‐6‐phosphate dehydrogenase deficiency (G6PDd), phenylketonuria (PKU) and galactosemia (GAL). Whilst massively parallel sequencing (MPS) allows researchers to screen several loci simultaneously for pathogenic variants, no screening programme uses MPS to uncover the variant spectra of these diseases in the Vietnamese population.MethodsPregnant women (mean age of 32) from across Vietnam attending routine prenatal health checks agreed to participate and had their blood drawn. MPS was used to detect variants in their G6PD, PAH and GALT genes.ResultsOf 3259 women screened across Vietnam, 450 (13.8%) carried disease‐associated variants for G6PD, PAH and GALT. The prevalence of carriers was 8.9% (291 of 3259) in G6PD and 4.6% (152 of 3259) in PKU, whilst GAL was low at 0.2% (7 of 3259). Two GALT variants, c.593 T > C and c.1034C > A, have rarely been reported.ConclusionThis study highlights the need for routine carrier screening, where women give blood whilst receiving routine prenatal care, in Vietnam. The use of MPS is suitable for screening multiple variants, allowing for identifying rare pathogenic variants. The data from our study will inform policymakers in constructing cost‐effective genetic metabolic carrier screening programmes.
Broadband CPW fed butterfly shape printed slot antenna
Authors: Arora Surbhi , Kumar Girish 
Published: May 2022

AbstractA broadband coplanar waveguide fed butterfly shape slot antenna is presented in this paper. The designed antenna operates in the frequency range from 1.89 to 5.21 GHz (93.5%) for S11 ≤ −10 dB with a broadside gain of 5 ± 1 dBi over the bandwidth of 1.97–5.19 GHz (90.3%). The designed antenna is uniplanar having the size of 0.5 λ0  × 0.28 λ0  × 0.005 λ0 (λ0 is the wavelength at the lowest operating frequency in free space). The proposed configuration has a stable radiation pattern over the operating frequency band. The designed antenna is fabricated and simulated results are validated with measured results.
Development of central venous access device‐associated skin impairment assessment instrument
Authors: Liu Min , Zheng Chonghao , Guan Xiangyun , Ke Ziwei , Zou Ping , Yang Yeqin 
Published: May 2022

AbstractAimTo develop an assessment tool to assess the severity and healing of skin impairment with the central venous access device.DesignDelphi technique.MethodsThe instrument domain list was developed through a systematic literature review and semi‐structured interviews. Experts from China evaluated the relevance and significance of these items in assessing the degree of skin impairment surrounding central venous access device sites through two Delphi rounds. The APA Style JARS checklist for this article was used.ResultsFor the systematic literature review, 28 articles were included to develop the wound assessment instrument. From the articles and interview contents, 15 criteria were selected based on reporting frequency. After further screening via in‐depth discussion, the central venous access devices associated with the skin impairment assessment tool were refined to include 14 major domains. Through a two‐phase Delphi process, 71 items in 12 domains were ultimately retained.
Isothermal crystallization behaviors of isotactic polypropylene with ultrasonically‐modified calcium sulfate whisker as β‐nucleating agent
Authors: Shi Wenjian , Xu Yong , Qin Jun , Li Xing , Lv Qing , Chen Xiaolang , Yu Jie , Chen Mengyu 
Published: May 2022

AbstractIn this work, the effect of calcium sulfate whisker (CSW) and ultrasonically‐modified CSW (UCSW) on the crystal structure and isothermal crystallization of isotactic polypropylene (iPP) is studied by using differential scanning calorimetry (DSC), X‐ray diffraction (XRD), and polarized optical microscopy (POM). UCSW obviously increases heterogeneous nucleation. The isothermal crystallization kinetics of pure iPP, iPP/CSW, and iPP/UCSW composites are analyzed by the Avrami method. Although the Avrami exponent (n) of these samples only changed slightly, the half crystallization time (t1/2) indicates that CSW and UCSW decrease the overall crystallization time and increase the crystallization rate (Rc). POM results show that most crystals are β‐iPP shaped and the spherulite size decreases significantly with the addition of UCSW. The apparent equilibrium temperature of iPP/UCSW composites is lower than that of pure iPP and iPP/CSW composites. The values of β‐iPP fold surface free energy (σe) and the nucleation parameter (Kg) are much lower than that of α‐iPP for these iPP composites. The content of β‐crystal in iPP composites increases due to the addition of UCSW.
First Asymmetric Synthesis of Passerini‐Type Condensation Products in Water Using Pregabalin: A Chiral Amino Acid for the Efficient Asymmetric Induction
Authors: Mousapour Maryam , Hassani Seyyed Alireza Mousazadeh , Shirini Farhad 
Published: May 2022

AbstractThis article describes the use of Pregabalin as a commercially available chiral amino acid in the efficient synthesis of the Passerini‐type condensation products via two‐component condensation of aromatic aldehydes with cyclohexyl isocyanide. All reactions are accompanied with aerobic oxidation of aldehydes in water leading to chiral α‐acyloxycarboxamides with moderate to good enantioselectivities (up to 88 % ee) under green conditions such as nonmetal source. This is the first report of asymmetric synthesis of Passerini products in water.