bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laboratory Model Test of Fully Buried Portal Frame-Shaped Slope-Stabilizing Piles
Authors: Dai Zihang , Qiu Zhihua , Li Hengyang , Lu Caijin , Yang Jianhui 
Published: January 2022

Abstract
Fully buried portal frame-shaped piles have been widely used to control and stabilize large-scale landslides or slopes. However, the working mechanism of portal frame piles, such as the soil–pile interaction and load transfer behavior, is still not fully understood, which has limited the development of effective pile designs and construction. In this study, a well-designed laboratory model test was conducted in a sandy soil slope with a man-made slip surface. Nine portal frame piles were installed, synthetically considering the pile spacing between the rear and front piles as well as the support condition of the pile ends. To make the test closer to reality, in addition to a small thrust due to the excavation of the slope, greater landslide thrusts were imposed on the rear side of the portal frame piles by gradually applying static loads on the top of the slope. It is found that in addition to a concentrated thrust transferred via the cap beam, a landslide thrust accounting for 30 to 60 % of the landslide thrust on the rear pile was transmitted to the front pile by the soil sandwiched between the rear and front piles, which should not be ignored in designs. Meanwhile, to evenly mobilize the bearing capacity of both the rear and front piles, the reasonable spacing between them should be 1.0 to 1.5 times the diameter of the pile. The study also shows that portal frame piles should be embedded in a stable soil layer rather than the bedrock if they can meet the requirements for bearing capacity.
Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis
Authors: Islam Sadequl , Sun Yang , Gao Yuan , Nakamura Tomohisa , Noorani Arshad Ali , Li Tong , Wong Philip C. , Kimura Noriyuki , Matsubara Etsuro , Kasuga Kensaku , Ikeuchi Takeshi , Tomita Taisuke , Zou Kun , Michikawa Makoto 
Published: January 2022

Alzheimer's disease (AD) is a debilitating dementia characterized by progressive memory loss and aggregation of amyloid-β (Aβ) protein into amyloid plaques in patient brains. Mutations in presenilin (PS) lead to abnormal generation of Aβ, which is the major cause of familial AD (FAD), and apolipoprotein E4 (ApoE4) is the major genetic risk factor for sporadic AD (SAD) onset. However, whether dysfunction of PS is involved in the pathogenesis of SAD is largely unknown. We found that ApoE secretion was completely abolished in PS-deficient cells and markedly decreased by inhibition of γ-secretase activity. Blockade of γ-secretase activity by a γ-secretase inhibitor, DAPT, decreased ApoE secretion, suggesting an important role of γ-secretase activity in ApoE secretion. Reduced ApoE secretion is also observed in nicastrin-deficient cells with reduced γ-secretase activity. PS deficiency enhanced nuclear translocation of ApoE and binding of ApoE to importin α4, a nuclear transport receptor. Moreover, the expression of PS mutants in PS-deficient cells suppressed the restoration effects on ApoE secretion compared with the expression of wild-type PS. Plasma ApoE levels were lower in FAD patients carrying PS1 mutations compared with normal control subjects. Our findings suggest a novel role of PS contributing to the pathogenesis of SAD by regulating ApoE secretion.SIGNIFICANCE STATEMENTFamilial AD (FAD) typically results from mutations in the genes encoding amyloid precursor protein, presenilin 1 (PS1), or PS2. Many PS mutants have been found to exert impaired γ-secretase activity and increased amyloid-β 42 (Aβ42)/Aβ40 ratio, which induce early amyloid deposition and FAD. On the other hand, apolipoprotein E4 (ApoE4) is the major genetic risk factor for sporadic AD (SAD) and contributes to AD pathogenesis because it has reduced Aβ clearance capability compared with ApoE3 and ApoE2. FAD and SAD have long been considered to be caused by these two independent mechanisms; however, for the first time, we demonstrated that PS is essential for ApoE secretion and PS mutants affected ApoE secretionin vitroand in human samples, suggesting a novel mechanism by which PS is also involved in SAD pathogenesis.
Advance Care Planning Preferences for Adolescents With Cardiac Disease
Authors: Hansen Katherine , Edwards Lindsay A , Yohannes Kifle , Luong Roger , Lin Amy , Long Jin , Halpern-Felsher Bonnie , Cohen Harvey , Kaufman Beth D. 
Published: January 2022

BACKGROUND AND OBJECTIVES
Adolescents with cardiac disease are at risk for life-changing complications and premature death. The importance of advance care planning (ACP) in adults with congenital heart disease and in pediatric patients with HIV and cancer has been demonstrated. ACP preferences of adolescents with heart disease have not been evaluated. We describe ACP preferences of adolescents with heart disease and compare with those of their caregivers.

METHODS
Outpatient adolescents aged 12 to 18 years with heart failure, cardiomyopathy, heart transplantation, or who were at risk for cardiomyopathy, as well as their caregivers, completed self-administered questionnaires which evaluated participants’ opinions regarding content and timing of ACP discussions, preferences for end-of-life communication, and emotional responses to ACP.

RESULTS
Seventy-eight adolescents and 69 caregivers participated, forming 62 adolescent-caregiver dyads. Adolescents and caregivers reported that adolescent ACP discussions should occur early in the disease course (75% and 61%, respectively). Adolescents (92%) wanted to be told about terminal prognosis, whereas only 43% of caregivers wanted the doctor to tell their child this information. Most adolescents (72%) and caregivers (67%) anticipated that discussing ACP would make the adolescent feel relieved the medical team knew their wishes. Most caregivers (61%) believed that adolescents would feel stress associated with ACP discussions, whereas only 31% of adolescents anticipated this.

CONCLUSIONS
Adolescents and their caregivers agree that ACP should occur early in disease course. There are discrepancies regarding communication of prognosis and perceived adolescent stress related to ACP discussions. Facilitated conversations between patient, caregiver, and providers may align goals of care and communication preferences.
Growth of nanoporous high-entropy oxide thin films by pulsed laser deposition
Authors: Guo Huiming , Wang Xin , Dupuy Alexander D. , Schoenung Julie M. , Bowman William J. 
Published: January 2022

AbstractHigh-entropy oxides (HEO) with entropic stabilization and compositional flexibility have great potential application in batteries and catalysis. In this work, HEO thin films were synthesized by pulsed laser deposition (PLD) from a rock-salt (Co0.2Ni0.2Cu0.2Mg0.2Zn0.2)O ceramic target. The films exhibited the target’s crystal structure, were chemically homogeneous, and possessed a three-dimensional (3D) island morphology with connected randomly shaped nanopores. The effects of varying PLD laser fluence on crystal structure and morphology were explored systematically. Increasing fluence facilitates film crystallization at low substrate temperature (300 °C) and increases film thickness (60–140 nm). The lateral size of columnar grains, islands (19 nm to 35 nm in average size), and nanopores (9.3 nm to 20 nm in average size) increased with increasing fluence (3.4 to 7.0 J/cm2), explained by increased kinetic energy of adatoms and competition between deposition and diffusion. Additionally, increasing fluence reduces the number of undesirable droplets observed on the film surface. The nanoporous HEO films can potentially serve as electrochemical reaction interfaces with tunable surface area and excellent phase stability.Graphical abstract
NOTE ON SUPER \((a,1)\)–\(P_3\)–ANTIMAGIC TOTAL LABELING OF STAR \(S_n\)
Authors: Rajkumar S. , Nalliah M. , Venkataraman Madhu 
Published: January 2022

Let \(G=(V, E)\) be a simple graph and \(H\) be a subgraph of \(G\). Then \(G\) admits an \(H\)-covering, if every edge in \(E(G)\) belongs to at least one subgraph of \(G\) that is isomorphic to \(H\). An \((a,d)-H\)-antimagic total labeling of \(G\) is bijection \(f:V(G)\cup E(G)\rightarrow \{1, 2, 3,\dots, |V(G)| + |E(G)|\}\) such that for all subgraphs \(H'\) of \(G\) isomorphic to \(H\), the \(H'\) weights \(w(H') =\sum_{v\in V(H')} f (v) + \sum_{e\in E(H')} f (e)\) constitute an arithmetic progression \(\{a, a + d, a + 2d, \dots , a + (n- 1)d\}\), where \(a\) and \(d\) are positive integers and \(n\) is the number of subgraphs of \(G\) isomorphic to \(H\). The labeling \(f\) is called a super \((a, d)-H\)-antimagic total labeling if \(f(V(G))=\{1, 2, 3,\dots, |V(G)|\}.\) In [5], David Laurence and Kathiresan posed a problem that characterizes the super \( (a, 1)-P_{3}\)-antimagic total labeling of Star \(S_{n},\) where \(n=6,7,8,9.\) In this paper, we completely solved this problem.
ON A CLASS OF EDGE-TRANSITIVE DISTANCE-REGULAR ANTIPODAL COVERS OF COMPLETE GRAPHS
Authors: Tsiovkina Ludmila Yu. 
Published: January 2022

The paper is devoted to the problem of classification of edge-transitive distance-regular antipodal covers of complete graphs. This extends the classification of those covers that are arc-transitive, which has been settled except for some tricky cases that remain to be considered, including the case of covers satisfying condition \(c_2=1\) (which means that every two vertices at distance 2 have exactly one common neighbour).Here it is shown that an edge-transitive distance-regular antipodal cover of a complete graph with \(c_2=1\) is either the second neighbourhood of a vertex in a Moore graph of valency 3 or 7, or a Mathon graph, or a half-transitive graph whose automorphism group induces an affine \(2\)-homogeneous group on the set of its fibres. Moreover, distance-regular antipodal covers of complete graphs with \(c_2=1\) that admit an automorphism group acting \(2\)-homogeneously on the set of fibres (which turns out to be an approximation of the property of edge-transitivity of such cover), are described. A well-known correspondence between distance-regular antipodal covers of complete graphs with \(c_2=1\) and geodetic graphs of diameter two that can be viewed as underlying graphs of certain Moore geometries, allows us to effectively restrict admissible automorphism groups of covers under consideration by combining Kantor's classification of involutory automorphisms of these geometries together with the classification of finite 2-homogeneous permutation groups.
On some uncertainties related to static liquefaction triggering assessments
Authors: Reid David , Dickinson Simon , Mital Utkarsh , Fanni Riccardo , Fourie Andy 
Published: January 2022

Static liquefaction has been identified as the cause of several recent tailings storage facility (TSF) failures. Partially based on the investigations carried out, significant advances on the analysis of static liquefaction triggering (SLT) have been made. These include applications of critical-state-based models in a stress–deformation framework to identify if in situ conditions are approaching a level where SLT could occur. However, several important uncertainties remain. In this work, three of these uncertainties (geostatic stress ratio K0, intermediate principal stress ratio and principal stress angle from vertical) were investigated, along with their effects (both independently and in conjunction) on the identification of SLT and slope failure. These uncertainties were examined through a series of numerical analyses of an idealised TSF. Various values of K0 were used to examine their effect on SLT, while different approaches were taken to assess the potential effects of the intermediate principal stress ratio and the principal stress angle from vertical on instability. This work revealed that the current state of knowledge in these areas is such that significant uncertainty seems unavoidable in attempting to identify exactly when a particular slope may undergo SLT. Experimental and in situ test programmes that may be useful in reducing this uncertainty are outlined.
Using LSTM Neural Networks for Onsite Earthquake Early Warning
Authors: Wang Chia-Yu , Huang Ting-Chung , Wu Yih-Min 
Published: January 2022

Abstract
Onsite earthquake early warning (EEW) systems determine possible destructive S waves solely from initial P waves and issue alarms before heavy shaking begins. Onsite EEW plays a crucial role in filling in the blank of the blind zone near the epicenter, which often suffers the most from disastrous ground shaking. Previous studies suggest that the peak P-wave displacement amplitude (Pd) may serve as a possible indicator of destructive earthquakes. However, the attempt to use a single indicator with fixed thresholds suffers from inevitable errors because the diversity in travel paths and site effects for different stations introduces complex nonlinearities. In addition, the short warning time poses a threat to the validity of EEW. To conquer the aforementioned problems, this study presents a deep learning approach employing long short-term memory (LSTM) neural networks, which can produce a highly nonlinear neural network and derive an alert probability at every time step. The proposed LSTM neural network is then tested with two major earthquake events and one moderate earthquake event that occurred recently in Taiwan, yielding the results of a missed alarm rate of 0% and a false alarm rate of 2.01%. This study demonstrates promising outcomes in both missed alarms and false alarms reduction. Moreover, the proposed model provides an adequate warning time for emergency response.
Reply to “Comment on ‘High-Definition Mapping of the Gutenberg–Richter b-Value and Its Relevance: A Case Study in Italy’ by M. Taroni, J. Zhuang, and W. Marzocchi” by Laura Gulia, Paolo Gasperini, and Stefan Wiemer
Authors: Taroni Matteo , Zhuang Jiancang , Marzocchi Warner 
Published: January 2022

Abstract
Taroni et al. (2021; hereafter TZM21) proposed a method to perform a spatial b-value mapping based on the weighted-likelihood estimation and applied this method to the Italian region as a tutorial example. In the accompanying comment, Gulia et al. (2021; hereafter GGW21) did not challenge the TZM21’s method, but they argued that the catalog used by TZM21 is contaminated by quarry blasts, introducing a bias that may impact any seismotectonic or hazard interpretations. Although in TZM21 the application to the Italian territory was only a tutorial example and we purposely did not make any thorough discussion on the meaning of the results in terms of seismotectonic or seismic hazards (that would have required many more analyses), we acknowledge the potential role of the quarry blasts, and we add some further analysis here. We thank GGW21 for giving us this opportunity. Here, removing the part of the catalog contaminated by quarry blasts and applying the same analysis as in TZM21, we obtain results that are very similar to the ones reported in TZM21; specifically, only one region that is characterized by low natural seismicity rate shows a marked effect of the quarry blasts on the b-value.
Dampak pandemi coronavirus disease 2019 terhadap kualitas publikasi ilmiah
Authors: Yenny Yenny 
Published: January 2022

Dunia medis belakangan ini digemparkan dengan dilaporkan adanya temuan kasus pneumonia tipe baru di kota Wuhan, Provinsi Hubei, Cina pada akhir Desember 2019.(1)Belakangan diketahui bahwapenyakit pneumonia tersebut disebabkanoleh patogen varian baru coronavirus yang disebut sebagai 2019-novel coronavirus (2019-nCoV)/severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) yang selanjutnya dikenal sebagai coronavirus disease 2019 (COVID-19)dan oleh the World Health Organization dinyatakan sebagai pandemi global pada tanggal 11 Maret 2020.(2)Semenjak itupara ilmuan mulai memfokuskan penelitian yang dilakukan pada topikyang berkaitan dengan COVID-19. Kondisi ini juga membawa dampak terdapatnya peningkatan volume publikasi artikel tentang COVID-19 yang sangat mencolok di mana dalam 6 bulan sejak terjadinya pandemi jumlah publikasi berbentuk riset, letters, reviews, notes, dan editorial yang berhubungan dengan COVID-19 dilaporkan berjumlah lebih dari 23.500 artikel.(3)
Study of fasting & PP C- peptide & its correlation with HbA1c in T2 Diabetes mellitus in population of Uttarakhand
Authors: Ahsan Farah , Qureshi Naeem , Samreen Sumera , Kukreti Sonali 
Published: January 2022

We aimed to provide correlation of Fasting & PP C-peptide with HbA1C in patients of T2 Diabetes Mellitus.: 50 patients admitted in IPD of Medicine department in Shri Mahant Indresh Hospital from April-August 2021. Serum samples taken for fasting & PP C-peptide and HbA1C for patients of T2 Diabetes Mellitus and run on VITROS 5600/7600 which is based on dry chemistry. : We took 50 patients who were T2DM then we did fasting C peptide & PP C-peptide and HbA1c. Out of 50, 15 were females &35 were males. Out of 50, 45 patients had raised HbA1C maximum around 8-10.Mean & SD for fasting C-Peptide for males was 1.346±1.070 & for females 2.442±2.57.Mean & SD for Post prandiol C-Peptide for males was 4.208±5.020 & for females 2.993±2.130.It was significant for fasting C- Peptide with P value 0.0371 and non significant for PP C peptide with p value 0.3731.: Insulin secretion estimated by measurement of Fasting C-Peptide was either normal or raised in newly diagnosed T2DM subjects in my study indicating predominant role of insulin resistence in the etiology. Further research can explore the exact contribution of insulin resistence and insulin secretory defects in this area.
Association of glycated haemoglobin and serum ferritin levels in type 2 diabetics of rural population
Authors: Sadashiv Jankar Jayshri 
Published: January 2022

Serum ferritin, an acute phase reactant, is an indicator of the body's iron reserves. Increased body iron reserves and subclinical hemochromatosis have been linked to the development of hyperglycaemia, type 2 diabetes, metabolic syndrome, and potentially diabetic retinopathy, nephropathy, and vascular dysfunction, according to recent research. The objective of this study was to see if there was a link between Serum Ferritin and Type 2 diabetes and metabolic syndrome, as well as to see if there was a link between S. ferritin and HbA1c.The present study included 50 diagnosed cases of type 2 diabetes mellitus (males: 32, females: 18) and 50 healthy controls of same age (males: 28, females: 22). Serum ferritin levels, glycated hemoglobin were measured and compared. : When diabetic patients were compared to controls, serum ferritin was considerably greater, and serum ferritin had a positive correlation with the duration of diabetes and glycated hemoglobin. Positive correlation was found between serum ferritin levels and glycated hemoglobin and duration of disease.
Observational retrospective study of subaxial cervical spine trauma at tertiary care centre
Authors: Venkati Gajbhare Sunil , Satpaty Ayushman , Pandey Nityanand , Prasad Ravi Shankar 
Published: January 2022

The aim of this study is to compare between various treatment modalities available for treatment of subaxial cervical spine injuries due to trauma A total of 172 patients of subaxial cervical spine injuries were assessed retrospectively about their mode of injury, clinical course, definitive treatment given and its outcome. As the study was Descriptive and retrospective in nature involving only patient case files, statistical test is not applied to the study In our study 44 patients suffered from vertebral body fracture while 108 patients had spinal canal compromise due to other injuries. 16 patients had quadriplegia, 24 patients had grade 4 power in upper and lower extremities, and roots were involved in 46 patients. In 44 patients complete corpectomy was performed with placement of tricorticate graft taken from fibula, this graft was fixed in place with titanium plate and four screws.From this study it can be concluded that Patients treated with anterior approach had better outcome in relation to the fixation and fusion of the spine, reconstruction is more better in anterior approach.
An online knowledge-attitude-practice survey in the community about diabetes mellitus in India
Authors: Chakraverty Raja , Samanta Kalyan , Bandyopadhyay Jyotirmoy , Sarkar Chandrima 
Published: January 2022

To address the reasons for it is important to understand the knowledge, attitude and practices (KAP) of all pertinent stakeholders. This multicentrrising burden of Diabetes mellitus in India this survey is aimed at understanding the KAP quotients of the community regarding knowledge of laypersons regarding diabetes mellitus as this is lacking in Indian studies. A cross-sectional survey was conducted through online mode in India using a validated, field-tested questionnaire incorporating KAP domain questions regarding Diabetes mellitus (DM). Scores to questions were appropriately assigned. The mean (SD) age of the respondents was 35.2 (12.61) y and 62% had a graduate or higher level of education. The median (IQR) KAP scores were 10 (8-12), 5 (3-5) and 2 (2-3) out of a maximum of 18, 5 and 6, respectively. Higher educational and socioeconomic levels were associated with better attitude scores, but knowledge levels were comparable. Correlations between KAP scores were poor. This study reveals that laypeople have appropriate knowledge and attitude regarding diabetes mellitus to some degree but there are important lacunae and practices are often found wanting. These issues need to be addressed in sustained public sensitization and motivational campaigns to improve the future and treatment outcomes of Diabetes mellitus in India.
Retrospective, observational study to see the effect of evogliptin on continuous glucose monitoring (CGM) in T2DM Indian patients: A real-world experience
Authors: Trailokya Abhijit , Erande Suhas , Aiwale Amol 
Published: January 2022

This study aimed to assess effectiveness of Evogliptin 5 mg through continues glucose monitoring (CGM) in patients with T2DM in retrospective observational real world settings. Overall 6 patients who received Evogliptin as routine clinical practice in management of T2DM were analyzed retrospectively from single center. Data collected from past medical records. FreeStyle Librepro 1.0.6 was used for CGM. CGM was done 15 days prior to adding Evogliptin and repeated immediately after that for next 15 days. Mean BG level, Percentage time in target range (80-140mg/dl), Percentage time above target and Percentage time below target were assessed prior and after adding Evogliptin in existing treatment regimen. Significant reduction in Mean blood glucose level seen after adding Evogliptin in existing treatment regimen from 215 mg/dl to 138 mg/dl (-77 mg/dl P=0.006). Significant improvement seen in Percentage time in target range (80-140mg/dl) from 17% to 44% (27% P value 0.007) and in Percentage time above target from 81% to 43% (- 38%, P valve 0.003). 13.5 % of the patients seen below target. Evogliptin was found to be effective when added to the patients who were uncontrolled on other oral anti-diabetic medications. It effectively showed improvement in continues glucose monitoring (CGM) parameters like Mean blood glucose, more number of patients were in Time in Target range i.e (80-140mg/dl) after adding Evogliptin to existing anti-diabetic medications & well tolerated. Small sample size and retrospective study