bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attitudes toward a COVID-19 vaccine and vaccination status in cancer patients: a cross-sectional survey
Authors: Heyne Svenja , Esser Peter , Werner Anne , Lehmann-Laue Antje , Mehnert-Theuerkauf Anja 
Published: February 2022

Abstract
Purpose
We aim to assess attitudes toward a COVID-19 vaccine and vaccination status in cancer patients and to explore additional factors such as the level of information and comprehensibility and accessibility of this information, anxiety symptoms in general and toward COVID-19, and general health literacy.

Methods
We included 425 outpatients (mean age 61.4, age range 30–88 years, 60.5% women) of the Psychosocial Counseling Center for Cancer patients of the Department of Medical Psychology and Medical Sociology, Leipzig. We recorded attitudes toward a COVID-19 vaccine and vaccination status via self-report. The impact of psychosocial factors, including anxiety (GAD-7), COVID-19-specific anxiety (OCS; FCV-19S) and health literacy (HLS-EU-Q16) were analyzed with point-biserial correlations using Pearson’s r.

Results
We found that the vast majority (95.5%) reported being vaccinated against COVID-19 and that overall trust in safety and protective effects of a COVID-19 vaccine was high (90.9%). The vaccination readiness among nonvaccinated cancer survivors was low to very low with “fear of side effects” the most mentioned (72.2%) reason against a COVID-19 vaccine. There was no significant correlation between vaccination status and fear or anxiety symptomatology, and health literacy. Obsessive thoughts about COVID-19 was significantly higher in nonvaccinated cancer patients.

Conclusions
Majority of respondents are positive about COVID-19 vaccine, accompanied by a very high rate of COVID-19 immunization in our sample. Further studies with a larger sample of nonvaccinated cancer patients should further investigate the relationship on fear and vaccination hesitancy and align communication strategies accordingly.
A two-phase comprehensive NSCLC prognostic study identifies lncRNAs with significant main effect and interaction
Authors: Zhu Jing , Guan Jinxing , Ji Xinyu , Song Yunjie , Xu Xiaoshuang , Wang Qianqian , Zhang Quanan , Guo Renhua , Wang Rui , Zhang Ruyang 
Published: February 2022

AbstractLong noncoding RNA (lncRNA) are involved in regulating physiological behaviors for various malignant tumors, including non-small-cell lung cancer (NSCLC). However, few studies comprehensively evaluated both lncRNA–lncRNA interaction effects and main effects of lncRNA on overall survival of NSCLC. Hence, we performed a two-phase designed study of lncRNA expression in tumor tissues using 604 NSCLC patients from The Cancer Genome Atlas as the discovery phase and 839 patients from Gene Expression Omnibus as the validation phase. In the discovery phase, we adopted a two-step strategy, Screening before Testing, for dimension reduction and signal detection. These candidate lncRNAs first screened out by the weighted random forest (Ranger), were then tested through the Cox proportional hazards model adjusted for covariates. Significant lncRNAs with either type of effects aforementioned were carried forward into the validation phase to confirm their significances again. As a result, in the discovery phase, 19 lncRNAs were identified by Ranger, among which five lncRNAs and one pair of lncRNA–lncRNA interaction exhibited significant effects (FDR-q ≤ 0.05) main and interaction effects on NSCLC survival, respectively, through Cox model. After the independent validation, we finally observed that one lncRNA (ENSG00000227403.1) with main effect was robustly associated with NSCLC prognosis (HRdiscovery = 0.90, P = 1.20 × 10–3; HRvalidation = 0.94, P = 4.11 × 10–3) and one pair of lncRNAs (ENSG00000267121.4 and ENSG00000272369.1) had significant interaction effect on NSCLC survival (HRdiscovery = 1.12, P = 3.07 × 10–4; HRvalidation = 1.11, P = 0.0397). Our comprehensive NSCLC prognostic study of lncRNA provided population-level evidence for further functional study.
Image and audio caps: automated captioning of background sounds and images using deep learning
Authors: Poongodi M. , Hamdi Mounir , Wang Huihui 
Published: February 2022

AbstractImage recognition based on computers is something human beings have been working on for many years. It is one of the most difficult tasks in the field of computer science, and improvements to this system are made when we speak. In this paper, we propose a methodology to automatically propose an appropriate title and add a specific sound to the image. Two models have been extensively trained and combined to achieve this effect. Sounds are recommended based on the image scene and the headings are generated using a combination of natural language processing and state-of-the-art computer vision models. A Top 5 accuracy of 67% and a Top 1 accuracy of 53% have been achieved. It is also worth mentioning that this is also the first model of its kind to make this forecast.
Epidemiological trends of low back pain at the global, regional, and national levels
Authors: Wang Linfeng , Ye Hong , Li Zhichao , Lu Chengwu , Ye Jian , Liao Mingxin , Chen Xiaojie 
Published: February 2022

Abstract
Purpose
We aimed to assess the global, regional, and national burdens of low back pain (LBP) from 1990 to 2019 by gender, age, and the sociodemographic index (SDI) from the Global Burden of Disease (GBD) 2019 study.

Methods
The number of incident cases, disability-adjusted life years (DALYs), age-standardized incidence rates, and age-standardized DALY rates during 1990–2019 were obtained from the GBD 2019 study. The estimated annual percentage changes (EAPCs) in the age-standardized incidence rates and age-standardized DALY rates were determined to measure the temporal trends of LBP.

Results
In 2019, there were an estimated 223.5 million cases of LBP and 63.7 million LBP-related DALYs worldwide. During 1990–2019, the age-standardized incidence rate [EAPC =  − 0.41; 95% confidence interval (CI) − 0.46 to − 0.36] and age-standardized DALY rate decreased (EAPC =  − 0.51; 95% CI − 0.56 to − 0.46) globally. The age-standardized incidence rate of LBP decreased the most in low-middle SDI regions. The age-standardized incidence rate of LBP decreased the most in South Asia (EAPC, − 1.51), East Asia (EAPC, − 0.68), and Australasia (EAPC, − 0.26). The incidence in male subjects was lower than that in female subjects. The largest decreases in the age-standardized incidence rate and age-standardized DALY rate of LBP were observed in India, and China.

Conclusions
The global age-standardized incidence rate and age-standardized DALY rate of LBP showed a downward trend, especially in East and South Asia. In addition, a heavier burden of LBP was observed in older and female populations.
Evaluation of the RSR 3 screen ICA™ and 2 screen ICA™ as screening assays for type 1 diabetes in Sweden
Authors: Törn Carina , Vaziri-Sani Fariba , Ramelius Anita , Elding Larsson Helena , Ivarsson Sten Anders , Amoroso Marie , Furmaniak Jadwiga , Powell Michael , Smith Bernard Rees 
Published: February 2022

AbstractAimThe study aim was to evaluate the RSR 3 Screen ICA™ and 2 Screen ICA™ for detection of islet cell autoimmunity in healthy Swedish subjects and patients with newly diagnosed type 1 diabetes (T1D).Methods3 Screen is designed for combined detection of autoantibodies to glutamic acid decarboxylase (GADA), to the islet antigen IA-2 (IA-2A) and to zinc transporter 8 (ZnT8A), while 2 Screen detects GADA and IA-2A. Serum samples from 100 T1D patients at onset and 200 healthy controls were studied.Results3 Screen achieved 93% assay sensitivity and 97.5% specificity, while 2 Screen achieved 91% assay sensitivity and 98.5% specificity. Samples were also tested in assays for individual autoantibodies. There was only one 3 Screen positive healthy control sample (0.5%) that was positive for multiple autoantibodies (IA-2A and ZnT8A). In contrast, most of the 93 3 Screen positive patients were positive for multiple autoantibodies with 72% (67/93) positive for both GADA and IA-2A and 57% (53/93) positive for three autoantibodies (GADA, IA-2A and ZnT8A). Insulin autoantibodies (IAA, measured by radioimmunoassay) were positive in 13 patients and two healthy controls.Conclusion3 Screen achieved high sensitivity and specificity, suitable for islet cell autoimmunity screening in a healthy population. In the case of 3 Screen positivity, further assays for GADA, IA-2A and ZnT8A are required to check for multiple autoantibody positivity, a hallmark for progression to T1D. In addition, testing for IAA in children below two years of age is warranted.
Die primäre und die psychiatrisch-„komorbide“, nichtorganische Insomnie in einem neurologisch geführten Schlaflabor
Authors: Deutsch-Lang Sarah , Kuchling Maria , Valeske Isabel , Hulle-Wegl Petra , Stepansky Robert , Lang Wilfried 
Published: March 2022

ZusammenfassungPatientinnen und Patienten, die in einem neurologischen Schlaflabor die Abschlussdiagnose nichtorganische Insomnie erhalten, leiden zu einem großen Teil (34 von 43 Personen) unter einer psychiatrischen Erkrankung: Persönlichkeitsstörungen, mit und ohne zusätzliche affektive Störung, Depression, Dysthymie, Zyklothymie, bipolare Störung, Angststörungen (generalisierte Angststörung, soziale Phobie), somatoforme (autonome) Funktionsstörung, hypochondrische Störung, Zwangsstörung, Anpassungsstörungen nach dramatischen Lebensereignissen sowie posttraumatische Belastungsstörungen. Sie befinden sich in laufender psychiatrischer und psychotherapeutischer Behandlung, leiden aber anhaltend unter den Symptomen der Insomnie. Allen Patientinnen und Patienten mit nichtorganischer Insomnie wird die kognitive Verhaltenstherapie der Insomnie angeboten.
Is the pattern of mandibular asymmetry in mild craniofacial microsomia comparable to non-syndromic class II asymmetry?
Authors: Chen Yun-Fang , Vinayahalingam Shankeeth , Bergé Stefaan , Liao Yu-Fang , Maal Thomas , Xi Tong 
Published: February 2022

Abstract

Objectives
To compare the characteristics of mandibular asymmetry in patients with unilateral craniofacial microsomia (CFM) and class II asymmetry.

Materials and methods
Pretreatment cone-beam computed tomography of consecutive adults with Pruzansky-Kaban type I and IIA CFM (CFM group) was analyzed by 3D cephalometry. Fourteen mandibular landmarks and two dental landmarks were identified. The mandibular size and positional asymmetry were calculated by using landmark-based linear and volumetric measurements, in terms of asymmetry ratios (affected/non-affected side) and absolute differences (affected − non-affected side). Results were compared with non-syndromic class II with matched severity of chin deviation (Class II group). Statistical analyses included independent t test, paired t test, chi-square test, and ANOVA.

Results
CFM group (n, 21; mean age, 20.4 ± 2.5 years) showed significantly larger size asymmetry in regions of mandibular body, ramus, and condyle compared to Class II group (n, 21; mean age, 27.8 ± 5.9 years) (p < 0.05). The curvature of mandibular body was asymmetric in CFM. Regarding the positional asymmetry of mandibular body, while a comparable transverse shift and a negligible yaw rotation were found among the two groups, the roll rotation in CFM was significantly greater as well as the occlusal (6.06° vs. 4.17°) and mandibular (7.84° vs. 2.80°) plane cants (p < 0.05).

Conclusions
Mild CFM showed significantly more severe size asymmetry and roll rotation in mandible than non-CFM class II asymmetry.

Clinical relevance
To improve the mandibular size and positional asymmetry in CFM, adjunct hard tissue augmentation or reduction in addition to OGS orthodontics with a meticulous roll and yaw planning is compulsory, which is expected to be distinct from treating non-CFM class II asymmetry.
The role of maternal trauma and discipline types in emotional processing among Syrian refugee children
Authors: Peltonen Kirsi , Gredebäck Gustaf , Pollak Seth D. , Lindskog Marcus , Hall Jonathan 
Published: February 2022

AbstractStressful experiences in armed conflict incur intergenerational effects through parental behaviors with their children. A recent study reported that among Syrian refugee families, mothers’ (but not fathers’) post-traumatic stress (PTS) impacted children’s emotional processing. In this study, we aim to shed further light on this phenomenon by analyzing how the parenting practices in the context of post-traumatic stress confers protection or risk for children’s emotional processing. Participants were 6–18-year-old children (n = 212) and their mothers (n = 94), who fled from Syria and were residing in Turkish communities. We used the computer-based emotional processing task including photos of facial movements typically associated with different emotions to measure children’s capacity for emotional processing. Mothers reported their PTS and the discipline types they use, as well as the contextual factors related to their refugee background. Linear mixed effect models were constructed first, to find out the discipline types that are most strongly associated with emotional processing of the child, and second, to examine whether these discipline types moderate the effect of maternal PTS on children's emotional processing. Finally, generalized linear models were constructed to examine which contextual factors are associated with the use of these discipline types by mothers. We found that spanking as a discipline type was associated with poorer child emotional processing, whereas withholding of media access was associated with better emotional processing. Younger and less religious mothers were more prone to use spanking. The study underlines the need for parenting programs alongside with efforts to address mental health issues among mothers living under armed conflict.
Forest maturity has a stronger influence on the prevalence of spider monkeys than howler monkeys in an anthropogenically impacted rainforest landscape
Authors: Shedden A. , Dunn J. C. , Martínez-Mota R. , Cristóbal-Azkárate J. , Gillingham P. K. , MacSwiney-González C. , Newton A. C. , Rodríguez-Luna E. , Korstjens A. H. 
Published: February 2022

AbstractThe transformation and depletion of primary forest over the past few decades have placed almost half of the world’s primate species under the threat of extinction. Developing any successful conservation program for primates requires distribution and demography data, as well as an understanding of the relationships between these factors and their habitat. Between March and June 2010 and 2011 we collected data on the presence and demographic parameters of howler and spider monkeys by carrying out surveys, and validated our findings using local knowledge. We then examined the relationship between forest type and the presence of these primates at 54 sites in the northern area of the Selva Zoque Corridor, Mexico. We detected 86 spider monkey groups across 31 plots and censused 391 individuals (mean ± SD = 5.9 ± 3.0 individuals per sub-group, n = 67 sub-groups). We also detected 69 howler monkey groups across 30 plots and censused 117 individuals (mean ± SD = 5.3 ± 2.4 individuals per group, n = 22 groups). Howler monkey presence was not related to any specific vegetation type, while spider monkeys were present in areas with a higher percentage of tall forest (trees > 25 m high). Overall, spider monkeys were more prevalent than howler monkeys in our sampling sites and showed demographic characteristics similar to those in better protected areas, suggesting that the landscape features in the Uxpanapa Valley are suitable for their needs. Conversely, howler monkey presence was found to be more limited than in other regions, possibly due to the extended presence of spider monkeys.
The past, present and future of euro area monetary-fiscal interactions
Authors: Whelan Karl 
Published: March 2022

Abstract
The EU’s Treaties were designed to limit the interaction between fiscal and monetary policies. However, over the last decade, the introduction of the ECB’s Outright Monetary Transactions (OMT) programme and its sovereign bond purchase programmes has created some strong linkages between monetary and fiscal policies in the Eurosystem. The ECB’s monetary policies have improved fiscal debt sustainability and reduced the probability of sovereign default. However, there may need to be limits to the ECB’s purchases of sovereign bonds. This paper discusses the interactions between fiscal and monetary policies in the euro area and describes how the arguments raised by the European Court of Justice in the Weiss and Gauweiler cases suggest there may be hard limits on the size of the Eurosystem’s sovereign bond holdings. These limits may undermine the positive impact of the OMT announcement and force the ECB into some difficult choices in the coming years.
Amycolatopsis camponoti sp. nov., new tetracenomycin-producing actinomycete isolated from carpenter ant Camponotus vagus
Authors: Zakalyukina Yuliya V. , Osterman Ilya A. , Wolf Jacqueline , Neumann-Schaal Meina , Nouioui Imen , Biryukov Mikhail V. 
Published: February 2022

AbstractAn actinobacterial strain A23T, isolated from adult ant Camponotus vagus collected in Ryazan region (Russia) and established as tetracenomycin X producer, was subjected to a polyphasic taxonomic study. Morphological characteristics of this strain included well-branched substrate mycelium and aerial hyphae fragmented into rod-shaped elements. Phylogenetic analyses based on 16S rRNA gene and genome sequences showed that strain A23T was most closely related to Amycolatopsis pretoriensis DSM 44654T. Average nucleotide identity and digital DNA–DNA hybridization values between the genome sequences of isolate A23T and its closest relative, Amycolatopsis pretoriensis DSM 44654T, were 39.5% and 88.6%, which were below the 70% and 95–96% cut-off point recommended for bacterial species demarcation, respectively. The genome size of the isolate A23T was 10,560,374 bp with a DNA G + C content of 71.2%. The whole-cell hydrolysate contained meso-diaminopimelic acid and arabinose and galactose as main diagnostic sugars as well as ribose and rhamnose. It contained MK-9(H4) as the predominant menaquinone and iso-C16:0, iso-C15:0, anteiso-C17:0 and C16:0 as the major cellular fatty acids. Diphosphatidylglycerol and phosphatidylethanolamine prevailed among phospholipids. Mycolic acids were not detected. Based on the phenotypic, genomic and phylogenetic data, isolate A23T represents a novel species of the genus Amycolatopsis, for which the name Amycolatopsis camponoti sp. nov. is proposed, and the type strain is A23T (= DSM 111725T = VKM 2882T).
Intergenerational Transmission of Anxious Information Processing Biases: An Updated Conceptual Model
Authors: Aktar Evin 
Published: February 2022

AbstractAnxiety disorders are globally one of the most prevalent and disabling forms of psychopathology in adults and children. Having a parent with an anxiety disorder multiplies the risk of anxiety disorders in the offspring, although the specific mechanisms and processes that play a role in this intergenerational transmission remain largely unknown. According to information processing theories, threat-related biases in cognitive processing are a causal mechanism in the development and maintenance of anxiety. These theories propose that individuals with anxiety are more likely to cognitively process novel stimuli in their environment as threatening. Creswell and colleagues proposed a theoretical model that highlighted the role of these cognitive biases as a mechanism in the intergenerational transmission of anxiety (Creswell et al., in Hadwin, Field (eds) Information processing biases and anxiety: a developmental perspective, Wiley, pp 279–295, 2010). This model postulated significant associations between (1) parents’ and children’s threat-related cognitive biases (2) parents’ threat-related cognitive biases in their own and their child’s environment, (3) parents’ threat-related cognitive biases and parenting behaviors that convey anxiety risk to the offspring (e.g., modeling of fear, and verbal threat information transmission), and (4) parenting behaviors and child threat-related biases. This theoretical review collated the recent empirical work testing these four core hypotheses of the model. Building on the reviewed empirical work, an updated conceptual model focusing on threat-related attention and interpretation is proposed. This updated model incorporates the links between cognition and anxiety in parents and children and addresses the potential bidirectional nature of parent–child influences.
Documenting fishes in an inland sea with citizen scientist diver surveys: using taxonomic expertise to inform the observation potential of fish species
Authors: Ashley Elizabeth A. , Pattengill-Semmens Christy V. , Orr James W. , Nichols Janna D. , Gaydos Joseph K. 
Published: February 2022

AbstractLong-term monitoring enables scientists and managers to track changes in the temporal and spatial distributions of fishes. Given the anthropogenic stressors affecting marine ecosystem health, there is a critical need for robust, comprehensive fish monitoring programs. Citizen science can serve as a meaningful, cost-effective strategy to survey fish communities. We compared data from 13,000 surveys collected over 21 years (1998–2019) by Reef Environmental Education Foundation (REEF) volunteer divers to a published compilation of Salish Sea ichthyofauna collected using an assortment of methods. Volunteer divers observed 138 of 261 recognized species in the Salish Sea, expanded the range of 18 species into additional Salish Sea sub-basins, and identified one species novel to the Salish Sea (Gibbonsia metzi — Striped Kelpfish). To identify Salish Sea fish species that are most suitable to be monitored by underwater visual census and to evaluate confidence in in situ identification, we developed a categorization system based on the likelihood of recreational divers and snorkelers encountering a given species, and on whether identification required a specimen in hand or could be classified to species visually (with or without a high-quality photograph). REEF divers encountered 62% (138 of 223) of the visually detectable species occurring in the region and 85% (102 of 120) of species most likely to be observed by recreational divers. Our findings show that citizen scientists provide valuable monitoring data for over half of the 261 marine and anadromous fish species known to occupy the Salish Sea, many of which are not routinely monitored otherwise.