bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Crowd Crush at Mount Meron: Emergency Medical Services Response to a Silent Mass Casualty Incident
Authors: Daniel Donald Theodore Gordon , Alpert Evan Avraham , Jaffe Eli 
Published: July 2022

AbstractOn April 30, 2021, a total of 45 died and 112 were injured in a crowd crush at a religious festival on Mount Meron, Israel. Unlike a bomb blast, building collapse, mass shooting, or stampede, the incident lacked a dramatic, noticeable trigger and may be termed a “silent mass casualty incident (MCI).” This may have resulted in a slight delay in response. Magen David Adom (MDA)—Israel’s National Emergency Medical Services Organization—was the main prehospital response to the MCI. MDA’s intense planning, organization of medical infrastructure, and on-site MCI drill before the event allowed for the rapid, coordinated treatment and evacuation of casualties by ambulance and helicopter. The use of volunteers facilitated an effective response to the event. A “rolling reinforcement” system of ambulances helped treat and transport those at the scene while placing staff at stations throughout the country to serve routine emergency calls.
Population characteristics and stock assessment of European anchovy (Engraulis encrasicolus L., 1758) in coastal waters of the south-eastern Black Sea of Turkey
Authors: Çiloğlu Erhan , Şahin Cemalettin 
Published: July 2022

AbstractThis study was carried out throughout 10 fishing seasons between 2002 and 2018 to monitor the population and stock variations of Engraulis encrasicolus (L., 1758) on the south-eastern Black Sea coast of Turkey. Asymptotic length (L∞), growth constant (K) and growth performance indexes (φ) were calculated to be between 12.86 and 15.79 cm, 0.69 and 0.99, 2.10 and 2.29, respectively. Theoretical birth ages were determined to range between (to) −0.15 and −0.27, the maximum ages (tmax) ranged between 3.03 and 4.35, total mortality rates (Z) between 2.19 and 2.66, natural mortality rates (M) between 0.93 and 1.26, the fishing mortality rate (F) between 0.93 and 1.47, and the optimum fishing mortality rate (Fopt.) between 0.37 and 0.62. Fishing mortality rates (F) were estimated to be higher than the optimum fishing mortality rates (Fopt). Z/K ratios were determined to range between 1.91 and 3.43. Current exploitation rates (Ecurr.) were calculated to range between 0.42 and 0.62. The first recruit lengths (Lr) and first capture lengths (Lc50) were estimated to range between from 5.25–7.75 and from 7.66–8.74 cm, respectively. The first maturity lengths (Lm50) of E. encrasicolus ranged between 8.57 and 10.53 cm. The maximum sustainable exploitation levels (Emax) were determined to range between 0.72 and 0.83. These data indicate that if current levels of fishing pressure continue, anchovy stocks will collapse in the near future.
Systematic review of group-based creative arts interventions in support of informal care-givers of adults: a narrative synthesis
Authors: Watt Bec , Witt Susan , Susino Marco , Anolak Helena , Van Wegen Richard , Grocke Denise , Gordon Susan 
Published: July 2022

AbstractInformal care-givers play an important role, with health-care systems relying on the billions of hours of care they provide. Care-givers experience high levels of psychological distress and isolation; however, the efficacy of what support is the best for care-givers is unclear. The primary aim of this systematic review is to determine the effect of group creative arts interventions on informal care-givers of adults. The secondary aim is to understand the impact of group type, the primary outcomes and how they are measured. Given the heterogeneous nature of the included studies, a narrative synthesis approach was taken. Database searches identified 2,587 studies, 25 of which met the full inclusion criteria. Studies included group creative arts interventions for either care-givers only (N = 8) or for care-giver/cared-for dyads (N = 17). The majority of the participants in the studies were older Caucasian females. Group creative arts interventions are beneficial for care-givers and for the person being cared for; however, benefits differ depending on whether the group is for care-givers only or for care-giver/cared-for dyads. Future research will benefit from care-givers being involved in the design of the creative arts intervention to provide input regarding group type and relevant outcome measures. Future research should consider targeting their intervention to care-givers with a low baseline score to increase the ability of the study to demonstrate a significant difference.
Barriers and enablers to leisure provision in residential aged care: personal care attendant perspectives
Authors: Stoddart Sharon Rose , Courtney-Pratt Helen , Andrews Sharon 
Published: July 2022

AbstractThis exploratory descriptive study investigated barriers and enablers to the provision of leisure activities for people living in three Australian residential aged care facilities (RACFs) that operated under a household model of care. This research is unique in the international context, as few studies have explored the understandings and experiences of personal care attendants' (PCAs) perceptions of what impacts leisure provision for people living in RACFs. Qualitative data were collected from 17 PCAs via four focus groups. Barriers to leisure provision were identified as PCA–resident ratios, competing demands of the PCA role and a prioritisation of physical care tasks over leisure-related activities. The severity of residents' dementia (cognitive and functional deficits) as well as behavioural and psychological symptoms of dementia were also framed as barriers to participation in and the provision of leisure. Participants identified enablers of leisure provision as related to perceptions of leisure, the experiential knowledge of staff, organisational support and resourcing. The study findings suggest that enhancing leisure provision for people living with dementia will require attention to system issues (i.e. staffing levels, ratios, PCA role demands) as well as PCA knowledge and capability to facilitate person-centred leisure.
The Decline of Egoism
Authors: Shaver Robert 
Published: July 2022

AbstractSidgwick saw egoism as important and undefeated. Not long afterward, egoism is largely ignored. Immediately after Sidgwick, many arguments were given against egoism – most poor – but one argument deserves attention as both influential and plausible. Call it the “grounds objection.” It has two strands. It objects that there are justifying reasons for action other than that an action will maximize my self-interest. It also objects that sometimes, what makes an action right is a fact other than its maximizing my self-interest. I briefly explain and criticize many of the arguments given against egoism in the period, then explain and defend the grounds objection.
Barchan Slipface Grainflows: Characteristics and Kinematics
Authors: Sherman Douglas J. , Zhang Pei , Pelletier Jon , Ellis Jean , Farrell Eugene , Li Bailiang 
Published: July 2022

AbstractGravity‐driven grainflows on aeolian dunes are important agents of sand transport on Earth and Mars but have been the focus of few field studies. We present results from the first comprehensive field study to evaluate hypotheses posed by previous studies: (a) grainflow frequency depends on the sand transport rate; (b) grainflow magnitude is independent of sand transport rate; and (c) grainflow speed depends on its area. A barchan slipface was monitored with a terrestrial laser scanner and video camera, with measurements of wind speed and sand transport rate. More than 1,600 grainflows were detected and measured. Key findings support the first hypothesis, refute the second hypothesis, and support the third hypothesis. We also found that grainflow speeds measured in laboratory studies are substantially slower than comparable examples measured in this field study, and the grainflow speed and area relationships found for field and laboratory data are significantly different.
Space and Time Variability of Detachment‐ Versus Ramp‐Dominated Thrusting: Insights From the Outer Albanides
Authors: Mazzoli S. , Basilici M. , Spina V. , Pierantoni P. P. , Tondi E. 
Published: July 2022

AbstractDespite their markedly different structural setting, the northern and southern outer Albanides share a common tectonic evolution from detachment‐dominated to ramp‐dominated, basement‐involved thrusting. The former process (mainly Oligocene to Miocene) is essentially related with the occurrence of a thick décollement level represented by Triassic evaporites, while the latter involves basement ramps splaying out from a middle crustal décollement. As this weak crustal layer is inherited from the Mesozoic rifting stage, the original continental margin architecture is interpreted to strongly influence subsequent convergent deformation. The profoundly different nature of the two dominant décollements in the study area controlled the structural style of the fold and thrust belt. The decoupling capacity of the upper décollement is strongly dependent on the thickness of the Triassic evaporites. Where this is significant (≫1 km; southern outer Albanides), the occurrence of such a thick incompetent layer at the base of competent carbonate units favored the development of break‐thrust folds and imbrication of the sedimentary cover. Fold and thrust belt propagation was instead hindered where original stratigraphic variations resulted in a reduced thickness (≤1 km) of Triassic evaporites. On the other hand, the deeper middle crustal décollement is controlled by basement rheology. Its reactivation during plate convergence was assisted by collision‐related thermal weakening of the crust. This process governed late‐stage (<5 Ma) crustal‐scale tectonic inversion and plays a major role in controlling present‐day seismicity.
Organizing structural principles of the IL-17 ligand–receptor axis
Authors: Wilson Steven C. , Caveney Nathanael A. , Yen Michelle , Pollmann Christoph , Xiang Xinyu , Jude Kevin M. , Hafer Maximillian , Tsutsumi Naotaka , Piehler Jacob , Garcia K. Christopher 
Published: July 2022

AbstractThe IL-17 family of cytokines and receptors have central roles in host defence against infection and development of inflammatory diseases1. The compositions and structures of functional IL-17 family ligand–receptor signalling assemblies remain unclear. IL-17E (also known as IL-25) is a key regulator of type 2 immune responses and driver of inflammatory diseases, such as allergic asthma, and requires both IL-17 receptor A (IL-17RA) and IL-17RB to elicit functional responses2. Here we studied IL-25–IL-17RB binary and IL-25–IL-17RB–IL-17RA ternary complexes using a combination of cryo-electron microscopy, single-molecule imaging and cell-based signalling approaches. The IL-25–IL-17RB–IL-17RA ternary signalling assembly is a C2-symmetric complex in which the IL-25–IL-17RB homodimer is flanked by two ‘wing-like’ IL-17RA co-receptors through a ‘tip-to-tip’ geometry that is the key receptor–receptor interaction required for initiation of signal transduction. IL-25 interacts solely with IL-17RB to allosterically promote the formation of the IL-17RB–IL-17RA tip-to-tip interface. The resulting large separation between the receptors at the membrane-proximal level may reflect proximity constraints imposed by the intracellular domains for signalling. Cryo-electron microscopy structures of IL-17A–IL-17RA and IL-17A–IL-17RA–IL-17RC complexes reveal that this tip-to-tip architecture is a key organizing principle of the IL-17 receptor family. Furthermore, these studies reveal dual actions for IL-17RA sharing among IL-17 cytokine complexes, by either directly engaging IL-17 cytokines or alternatively functioning as a co-receptor.
Evaluation of early innate and adaptive immune responses to the TB vaccine Mycobacterium bovis BCG and vaccine candidate BCGΔBCG1419c
Authors: Gunasena Manuja , Shukla Rajni Kant , Yao Naiquan , Rosas Mejia Oscar , Powell Michael D. , Oestreich Kenneth J. , Aceves-Sánchez Michel de Jesús , Flores-Valdez Mario Alberto , Liyanage Namal P. M. , Robinson Richard T. 
Published: July 2022

AbstractThe vaccine Mycobacterium bovis Bacillus Calmette-Guérin (BCG) elicits an immune response that is protective against certain forms of tuberculosis (TB); however, because BCG efficacy is limited it is important to identify alternative TB vaccine candidates. Recently, the BCG deletion mutant and vaccine candidate BCGΔBCG1419c was demonstrated to survive longer in intravenously infected BALB/c mice due to enhanced biofilm formation, and better protected both BALB/c and C57BL/6 mice against TB-induced lung pathology during chronic stages of infection, relative to BCG controls. BCGΔBCG1419c-elicited protection also associated with lower levels of proinflammatory cytokines (i.e. IL6, TNFα) at the site of infection in C57BL/6 mice. Given the distinct immune profiles of BCG- and BCGΔBCG1419c-immunized mice during chronic TB, we set out to determine if there are early immunological events which distinguish these two groups, using multi-dimensional flow cytometric analysis of the lungs and other tissues soon after immunization. Our results demonstrate a number of innate and adaptive response differences between BCG- and BCGΔBCG1419c-immunized mice which are consistent with the latter being longer lasting and potentially less inflammatory, including lower frequencies of exhausted CD4+ T helper (TH) cells and higher frequencies of IL10-producing T cells, respectively. These studies suggest the use of BCGΔBCG1419c may be advantageous as an alternative TB vaccine candidate.
Novel 3-D action video game mechanics reveal differentiable cognitive constructs in young players, but not in old
Authors: Ono Tomihiro , Sakurai Takeshi , Kasuno Shinichi , Murai Toshiya 
Published: July 2022

AbstractVideo game research predominantly uses a “one game-one function” approach—researchers deploy a constellation of task-like minigames to span multiple domains or consider a complex video game to essentially represent one cognitive construct. To profile cognitive functioning in a more ecologically valid setting, we developed a novel 3-D action shooter video game explicitly designed to engage multiple cognitive domains. We compared gameplay data with results from a web-based cognitive battery (WebCNP) for 158 participants (aged 18–74). There were significant negative main effects on game performance from age and gender, even when controlling for prior video game exposure. Among younger players, game mechanics displayed significant and unique correlations to cognitive constructs such as aim accuracy with attention and stealth with abstract thinking within the same session. Among older players the relation between game components and cognitive domains was unclear. Findings suggest that while game mechanics within a single game can be deconstructed to correspond to existing cognitive metrics, how game mechanics are understood and utilized likely differs between the young and old. We argue that while complex games can be utilized to measure distinct cognitive functions, the translation scheme of gameplay to cognitive function should not be one-size-fits-all across all demographics.
Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice
Authors: West Eliza G. , McDermott Catherine , Chess-Williams Russ , Sellers Donna J. 
Published: July 2022

AbstractEvidence to support the effectiveness of β3-adrenoceptor agonist mirabegron and anti-muscarinic solifenacin in the management of bladder dysfunction caused by psychological stress is lacking. This study investigates whether mirabegron or solifenacin reduces the bladder overactivity caused by water avoidance stress (WAS) in mice. Female mice were exposed to WAS for 1 h/day for 10 days and received either placebo, solifenacin or mirabegron in drinking water. Controls were age-matched without stress exposure. Voiding behaviour and functional isolated whole bladder responses during distension and in response to pharmacological agents and electrical field stimulation was investigated. Urinary frequency was significantly increased following stress. Mice treated with mirabegron or solifenacin displayed significantly fewer voiding events compared to the stressed mice, and voiding frequency in drug-treated animals was comparable to unstressed controls. The maximal contractile responses of bladders to carbachol were significantly enhanced by stress and reduced by mirabegron but not solifenacin. The frequency of phasic bladder contractions following stimulation with carbachol was significantly enhanced following stress and remained elevated in the mirabegron treated group. However, treatment with solifenacin significantly reduced the frequency of phasic contractions to unstressed control levels. Solifenacin and mirabegron are beneficial in reducing the overall voiding dysfunction caused by WAS in mice.
Clearance and persistence of Escherichia coli in the freshwater mussel Unio mancus
Authors: Campos M. , Lobato-Bailón L. , Merciai R. , Cabezón O. , Torres-Blas I. , Araujo R. , Migura-Garcia L. 
Published: July 2022

AbstractThe excessive use of antibiotics has led to the emergence of resistant bacteria, mainly from the Enterobacterales group, with high pathogenic/zoonotic potentials that can lead to problems in public health. The increasing presence in freshwater ecosystems highlights the need to evaluate potential sentinel species as risk indicators for both ecosystem and human health. The freshwater mussels provide several ecosystem services, may represent potential sentinel species due to their ability to filter water and retain both organic and inorganic particles. We tested the capability of U. mancus to retain Escherichia coli as a model bacterial organism. Under experimental conditions, the mussels could clear suspended E. coli, facilitating its rapid elimination from water within the first 24 h after exposure. The species also presented a maximum retention time of 4 days. We also provide allometric equations correlating the filtering capacity with the length and the weight of mussel body parts often used in biometric studies. We provide a first assessment of the potential of the bivalve Unio mancus to act as a sentinel species for the detection of Enterobacterales and demonstrate the ability to act as a water cleaner.
The fusion–fission optimization (FuFiO) algorithm
Authors: Nouhi Behnaz , Darabi Nima , Sareh Pooya , Bayazidi Hadi , Darabi Farhad , Talatahari Siamak 
Published: July 2022

AbstractFusion–Fission Optimization (FuFiO) is proposed as a new metaheuristic algorithm that simulates the tendency of nuclei to increase their binding energy and achieve higher levels of stability. In this algorithm, nuclei are divided into two groups, namely stable and unstable. Each nucleus can interact with other nuclei using three different types of nuclear reactions, including fusion, fission, and β-decay. These reactions establish the stabilization process of unstable nuclei through which they gradually turn into stable nuclei. A set of 120 mathematical benchmark test functions are selected to evaluate the performance of the proposed algorithm. The results of the FuFiO algorithm and its related non-parametric statistical tests are compared with those of other metaheuristic algorithms to make a valid judgment. Furthermore, as some highly-complicated problems, the test functions of two recent Competitions on Evolutionary Computation, namely CEC-2017 and CEC-2019, are solved and analyzed. The obtained results show that the FuFiO algorithm is superior to the other metaheuristic algorithms in most of the examined cases.
Exploring the impact of southern ocean sea ice on the Indian Ocean swells
Authors: Sreejith Meenakshi , P. G. Remya , Kumar B. Praveen , Raj Abhijith , Nair T. M. Balakrishnan 
Published: July 2022

AbstractThe present study analyzes the impact of the Southern Ocean (SO) sea ice concentration on the north Indian Ocean (NIO) wave fields through swells using 6 years (2016–2021) of WAVEWATCH III (WWIII) simulations. We did two experimental runs of WWIII, one with sea ice concentration and winds as the forcing (W3with_ice) and the second run with only wind forcing (W3no_ice). Analysis shows the impact of the SO sea ice concentration on northward swell peaks in September–November, coinciding with the maximum sea ice extent in the Antarctic region of the Indian Ocean. W3no_ice simulations are biased more by ~ 60% and ~ 37% in significant wave height and period, respectively, against W3with_ice when compared with NIO mooring data. W3no_ice simulates low-frequency swells and travels fast towards NIO, with implications for operational oceanography. We have shown that the forecasts of the timing of high swell events along NIO coasts can be erroneous by ~ 12 h if the SO sea ice concentration is not included in the model. Further, W3no_ice could potentially produce false swell alerts along southeastern Australian coasts. In summary, our study highlights the importance of the SO sea ice concentration inclusion in the wave models to accurately simulate NIO waves.
Comparison of entomological impacts of two methods of intervention designed to control Anopheles gambiae s.l. via swarm killing in Western Burkina Faso
Authors: Sawadogo Simon P. , Niang Abdoulaye , Wu Sean L. , Millogo Azize A. , Bonds Jane , Latham Mark , Dabiré Roch K. , Tatarsky Allison , Tripet Frederic , Diabaté Abdoulaye 
Published: July 2022

AbstractOutdoor biting constitutes a major limitation of current vector control based primarily on long-lasting insecticidal nets and indoor residual spraying, both of which are indoor interventions. Consequently, malaria elimination will not be achieved unless additional tools are found to deal with the residual malaria transmission and the associated vector dynamics. In this study we tested a new vector control approach for rapidly crashing mosquito populations and disrupting malaria transmission in Africa. This method targets the previously neglected swarming and outdoor nocturnal behaviors of both male and femaleAnophelesmosquitoes. It involved accurate identification and targeted spraying of mosquito swarms to suppress adult malaria vector populations and their vectorial capacities. The impact of targeted spraying was compared to broadcast spraying and evaluated simultaneously. The effects of the two interventions were very similar, no significant differences between targeted spraying and broadcast spraying were found for effects on density, insemination or parity rate. However, targeted spraying was found to be significantly more effective than broadcast spraying at reducing the number of bites per person. As expected, each intervention had a highly significant impact upon all parameters measured, but the targeted swarm spraying required less insecticide.