bluuebunny/crossref_metadata_2025_split huggingface dataset:
Print media coverage of breastfeeding in Great Britain: Positive or negative?
Authors: Merritt Rowena , Eida Tamsyn , Safon Cara , Kendall Sally 
Published: November 2022

AbstractMedia can be a powerful communication tool to promote breastfeeding, influence mothers' breastfeeding behaviour, create positive social norms and generate support among stakeholders and policymakers for breastfeeding. However, negative stories could deter women from starting or continuing to breastfeed. This study aimed to describe the breadth and focus of the media coverage of breastfeeding and the message frames that are found in three of the most widely read national newspapers and three popular women's magazines in Great Britain over a 12‐month period, as part of the Becoming Breastfeeding Friendly in Great Britain (BBF‐GB) study. For this retrospective media analysis, 77 articles were identified and 42 were included in the study for coding and analysis. We conducted two content analyses to examine the articles' (1) message framing and (2) alignment with the eight components of an ‘enabling breastfeeding environment’ using the BBF Gear framework. Articles featuring breastfeeding appear in British newspapers and women's magazines all year round. Twenty‐four per cent had a neutral tone, while 59% predominantly focused on the positive aspects or positive social support for breastfeeding, and 17% were predominantly focused on the negative aspects or negative social attitudes towards breastfeeding. The articles mainly focused on personal stories reflecting societal barriers and positive shifts (68%), with 12% presenting an analysis of breastfeeding evidence or barriers. There were fewer references to the legislation (5%) and availability of funding (2%) and support (9%). There was no coverage of national coordination and strategy, evaluation systems, or the political will to raise breastfeeding rates.
Successful cardiac resynchronization therapy by left bundle branch area pacing through a chronically occluded left subclavian system with limited vascular access preventing coronary sinus lead implant
Authors: Liu Xiaoke 
Published: November 2022

AbstractBackgroundConventional cardiac resynchronization therapy (CRT) involves implantation of a coronary sinus pacing lead through a delivery sheath, which typically requires a large venous access through a safe sheath of 9 French or greater in size. In patients who have very limited access due to scar tissue from previous implants or critical venous stenosis/closure, such large caliber access may not be available.Methods and ResultsWe report a case of CRT procedure in an 84‐year‐old male with a previous history of ischemic dilated cardiomyopathy (ejection fraction 40%) who was dependent on right ventricular pacing with worsening heart failure symptoms. The patient was incidentally discovered to have chronic total closure (CTO) of the left subclavian vein during the procedure. Although the CTO was crossed by a wire and dilated, the venous access was limited to a 7 French sheath which rendered conventional CRT through coronary sinus lead implant impossible. However, using the left bundle branch area pacing (LBBAP) technique which requires a smaller venous access, we were able to successfully achieve CRT. Postprocedure, the patient's paced QRS duration narrowed from 198 to 130 ms. His heart failure symptoms improved, and ejection fraction increased to 45% one‐month after the procedure.ConclusionsIn patients with vascular access limited to a small caliber sheath not suitable for conventional CRT, LBBAP may help achieve procedural success and improve clinical outcome.
Perioperative intravenous lidocaine use in children
Authors: Heath Chloe , Hii Justin , Thalayasingam Priya , von Ungern‐Sternberg Britta S. , Sommerfield David 
Published: November 2022

AbstractPerioperative pain management impacts patient morbidity, quality of life, and hospitalization cost. In children, it impacts not only the child, but the whole family. Adjuncts for improved perioperative analgesia continue to be sought to minimize adverse side effects associated with opioids and for those in whom regional or neuraxial anesthesia is not suitable. The use of ketamine and alpha agonists may be useful in these settings but have noted adverse effects including hallucinations, hemodynamic instability, and excessive sedation. One alternative is intravenous lidocaine. Despite its off‐label use, intravenous lidocaine has demonstrated anti‐neuropathic, anti‐hyperalgesic, and anti‐inflammatory actions and is an emerging technique. Multiple studies in adults have demonstrated beneficial effects of perioperative intravenous lidocaine including improved perioperative analgesia with reduced postoperative opioid use, improved gastrointestinal function, earlier mobilization, and reduction in hospital length of stay. Despite the limited pediatric literature, some of these findings have been replicated. Large‐scale trials providing evidence for the pediatric pharmacokinetics and high‐quality safety data with respect to intravenous lidocaine are still however lacking. To date, dose ranges studied in the pediatric population have not been associated with serious side effects and current data suggests perioperative intravenous lidocaine in a subgroup of pediatric surgical patients seems well‐tolerated and beneficial.
Narratives, Ontological Security, and Unconscious Phantasy: Germany and the European Myth During the so‐called Migration Crisis
Authors: Gellwitzki C. Nicolai L. , Houde Anne‐Marie 
Published: November 2022

This article synthesizes scholarship on narratives and Kleinian defense mechanisms against anxiety to develop a framework that enables a nuanced understanding of ontological security‐seeking dynamics in times of crisis. Using the case study of the German narrative of the European Union during the so‐called migration crisis of 2015, this article engages with the broader question of how unconscious phantasy influences and guides decision‐making processes on a collective level as well as the question of how exactly narratives help subjects to manage anxiety to maintain a sense of ontological security. We show that, in the case of Germany, the EU offers a highly affective political myth that has guided both the decision‐making of the government during the crisis and the construction of German self‐identity narratives by attempting to introject the good part‐object of “Europeanness.” Crucially, German self‐identity narratives and narratives on the EU were not only inextricably linked but the EU also became an idealized (Kleinian) part‐object. During the so‐called migration crisis, this fostered processes of projective identification whereby decisions subverting European values and humanitarian narratives as well as general “badness” were externalized and projected onto other member states, most notably the Visegrád states.
Single step method for high yield human platelet lysate production
Authors: Delabie Willem , De Bleser Dominique , Vandewalle Vicky , Vandekerckhove Philippe , Compernolle Veerle , Feys Hendrik B. 
Published: November 2022

AbstractBackgroundWe aimed to develop a single step method for the production of human platelet lysate (hPL). The method must result in high hPL yields, be closed system and avoid heparin use.Study Design and MethodsThe method aimed at using glass beads and calcium. An optimal concentration of calcium and glass beads was determined by serial dilution. This was translated to a novel method and compared to known methods: freeze‐thawing and high calcium. Quality outcome measures were transmittance, fibrinogen and growth factor content, and cell doubling time.ResultsAn optimal concentration of 5 mM Ca2+ and 0.2 g/ml glass beads resulted in hPL with yields of 92% ± 1% (n = 50) independent of source material (apheresis or buffy coat‐derived). The transmittance was highest (56% ± 9%) compared to known methods (<39%). The fibrinogen concentration (7.0 ± 1.1 μg/ml) was well below the threshold, avoiding the need for heparin. Growth factor content was similar across hPL production methods. The cell doubling time of adipose derived stem cells was 25 ± 1 h and not different across methods. Batch consistency was determined across six batches of hPL (each n = 25 constituting concentrates) and was <11% for all parameters including cell doubling time. Calcium precipitation formed after 4 days of culturing stem cells in media with hPL prepared by the high (15 mM) Ca2+ method, but not with hPL prepared by glass bead method.DiscussionThe novel method transforms platelet concentrates to hPL with little hands‐on time. The method results in high yield, is closed system, without heparin and non‐inferior to published methods.
Risk and protective factors for self-harm and suicide in children and adolescents: a systematic review and meta-analysis protocol
Authors: Farbstein Dan , Lukito Steve , Yorke Isabel , Wilson Emma , Crudgington Holly , El-Aalem Omar , Cliffe Charlotte , Bergou Nicol , Itani Lynn , Owusu Andy , Sedgwick Rosemary , Singh Nidhita , Tarasenko Anna , Tucker Gavin , Woodhouse Emma , Suzuki Mimi , Myerscough Anna Louise , Lopez Chemas Natalia , Abdel-Halim Nadia , Del Giovane Cinzia , Epstein Sophie , Ougrin Dennis 
Published: November 2022

IntroductionSelf-harm and suicide are major public health concerns among children and adolescents. Many risk and protective factors for suicide and self-harm have been identified and reported in the literature. However, the capacity of these identified risk and protective factors to guide assessment and management is limited due to their great number. This protocol describes an ongoing systematic review and meta-analysis which aims to examine longitudinal studies of risk factors for self-harm and suicide in children and adolescents, to provide a comparison of the strengths of association of the various risk factors for self-harm and suicide and to shed light on those that require further investigation.Methods and analysisWe perform a systematic search of the literature using the databases EMBASE, PsycINFO, Medline, CINAHL and HMIC from inception up to 28 October 2020, and the search will be updated before the systematic review publication. Additionally, we will contact experts in the field, including principal investigators whose peer-reviewed publications are included in our systematic review as well as investigators from our extensive research network, and we will search the reference lists of relevant reviews to retrieve any articles that were not identified in our search. We will extract relevant data and present a narrative synthesis and combine the results in meta-analyses where there are sufficient data. We will assess the risk of bias for each study using the Newcastle–Ottawa Scale and present a summary of the quantity and the quality of the evidence for each risk or protective factor.Ethics and disseminationEthical approval will not be sought as this is a systematic review of the literature. Results will be published in mental health journals and presented at conferences focused on suicide prevention.PROSPERO registration numberCRD42021228212.
Evaluating the attitudes of mental health professionals towards trials of MDMA: a randomised vignette trial
Authors: Wright Dean J , Colagiuri Ben , Glozier Nick 
Published: November 2022

ObjectivesTo compare attitudes of mental health (MH) professionals towards trials of methylenedioxymethamphetamine-assisted psychotherapy (MDMA-AP), with a neutrally labelled pharmacotherapy trial.DesignA randomised controlled vignette study design, with experimenters blinded to group condition.SettingParticipants were recruited online via professional societies.ParticipantsPsychiatrists, psychologists and MH researchers from across Australia.InterventionsParticipants were randomly allocated to read a vignette about a trial of either MDMA-AP or a neutrally labelled pharmacotherapy.OutcomesComparison of the difference in four attitudes towards MDMA-AP and control: How likely they were to (1) recommend participating, or (2) object to participating in the trial; (3) their predicted efficacy; and (4) concerns about the safety of the trial.ResultsThere were no overall differences between professional’s attitudes towards MDMA-AP (n=51) and the control pharmacotherapy (n=43) trial vignettes. Psychiatrists were less likely to recommend participation in the MDMA-AP than the control trial (d=0.72, p=0.02), but did not differ in other attitudes. Psychologists and researchers did not differ in any attitudes. The correlation between professional experience and both: (1) concern about, and (2) strength of objection to, the trial, was higher for MDMA-AP, than control (d=0.60, p=0.01 andd=0.40, p=0.03, respectively).ConclusionsPsychiatrists, but not psychologists or researchers showed more hesitancy in recommending trials of MDMA-AP versus an unknown pharmacotherapy. Experienced MH professionals were more likely to have negative views about MDMA-AP trials than less experienced MH professionals. This may reflect the experience of prior unfulfilled pharmacotherapy innovation or exuberance associated with fewer years of practice. Research into, and implementation of, MDMA-AP may face barriers with certain MH professionals, which will need be addressed if MDMA-AP continues to show promise as an efficacious treatment.Trial registration numberThe study design was registered with the ANZCTR (ACTRN12620001068954).
Sport and exercise recommendations for pregnant athletes: a systematic scoping review
Authors: Wieloch Nora , Klostermann Anneke , Kimmich Nina , Spörri Jörg , Scherr Johannes 
Published: November 2022

ObjectivesTo analyse the available evidence and identify gaps in current knowledge regarding physical activity volume and intensity and their effects on pregnancy outcomes in female athletes.DesignScoping review.Data sourcesA structured literature search of three electronic databases (Embase, PubMed and Web of Science) was conducted on 25 February 2022, and a rerun search was conducted on 8 September 2022.Eligibility criteriaStudies were eligible if they contained information on the relevant population (ie, elite or competitive amateur female athletes), intervention/exposure (ie, minimum of 10 hours of sport per week) and fetal and maternal outcomes. Eligible comparators included female recreational athletes and pregnant non-exercisers.Risk of biasThe risk of bias was evaluated with the National Institutes of Health (National Heart, Lung and Blood Institute) quality assessment tool.ResultsThe results revealed a discrepancy between the number of original research papers and the number of reviews and recommendations derived from them. The identified studies focused primarily on pregnant recreational athletes. Sixteen clinical studies met the inclusion criteria. No adverse effects on maternal or fetal outcomes were reported. Only during performance tests involving acute intensive exercise with the mother exercising at more than 90% of her maximal heart rate did some fetuses experience decelerations in heart rate.Summary/conclusionA lack of high-quality studies and direct evidence on pregnant elite and competitive amateur female athletes is evident. Further prospective observational cohort studies are needed using new monitoring methods (eg, non-invasive, wireless monitoring systems) aiming to gain a broader understanding of the stress tolerance of pregnant athletes and fetuses during exercise. Following that, interventional studies with stress tests in laboratory settings should be conducted. Therefore, technology plays a decisive role in gaining new knowledge and providing evidence-based recommendations on this topic.PROSPERO registration numberCRD42022309541.
Proactive psychological and psychiatric support of patients with chronic non-communicable diseases in a randomised trial: a Ukrainian experience
Authors: Khaustova O O , Markova M V , Driuchenko M O , Burdeinyi A O 
Published: November 2022

BackgroundPresently, approaches for the early treatment of pathological anxiety in patients with chronic non-communicable diseases are lacking, thus delaying the initiation of symptom management at the early onset of the illness. Proactive psychological and psychiatric support, to alleviate subclinical symptoms of anxiety and to improve the quality of life in patients with chronic non-communicable diseases, is a promising candidate for the role of such therapy.AimsTo investigate and determine the effectiveness of proactive psychological and psychiatric support for alleviating subclinical symptoms of anxiety and improving quality of life, in patients with chronic non-communicable diseases.MethodsThe study design was a monocentric randomised controlled trial with parallel groups. The study, involving 193 inpatients with chronic non-communicable diseases, complied with the ethical and deontological norms in accordance with the principles set out in the Declaration of Helsinki. Instruments used in the study included the Hamilton Anxiety Scale (HAM-A) to assess subclinical symptoms, the Scale of Somatic Symptoms and the Chaban Quality of Life Scale. Block randomisation was used to randomise patients to a 2-month-long study group with a proactive counselling psychiatry model care or a control group with standard regulated treatment for chronic non-communicable diseases. The allocation ratio was 1.15:1 owing to the expectancy of a higher percentage of dropout in the intervention group.ResultsAfter 60 days of treatment (T2), there was a statistically significant difference in all clinical parameters between the study and control groups. The median HAM-A value differed between the groups by 4.87 points, with statistically significant lower results in the study group. The comparison of the study group’s scale values on day 1 and day 60 demonstrated statistically significant changes in all three indicators.ConclusionsOur results support existing evidence for the effectiveness of proactive psychological and psychiatric support to reduce subclinical anxiety and somatisation symptoms and to improve the quality of life for patients with common chronic non-communicable diseases. However, continued research on the effectiveness of proactive psychological and psychiatric support for patients with chronic non-communicable diseases is needed.
Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity
Authors: Kalim Khalid W , Yang Jun-Qi , Wunderlich Mark , Modur Vishnu , Nguyen Phuong , Li Yuan , Wen Ting , Davis Ashley Kuenzi , Verma Ravinder , Lu Qing Richard , Jegga Anil G , Zheng Yi , Guo Fukun 
Published: November 2022

BackgroundCancer immunotherapy has taken center stage in cancer treatment. However, the current immunotherapies only benefit a small proportion of patients with cancer, necessitating better understanding of the mechanisms of tumor immune evasion and improved cancer immunotherapy strategies. Regulatory T (Treg) cells play an important role in maintaining immune tolerance through inhibiting effector T-cell function. In the tumor microenvironment, Treg cells are used by tumor cells to counteract effector T cell-mediated tumor suppression. Targeting Treg cells may thus unleash the antitumor activity of effector T cells. While systemic depletion of Treg cells can cause excessive effector T-cell responses and subsequent autoimmune diseases, controlled targeting of Treg cells may benefit patients with cancer.MethodsTreg cells from Treg cell-specific heterozygous Cdc42 knockout mice, C57BL/6 mice treated with a Cdc42 inhibitor CASIN, and control mice were examined for their homeostasis and stability by flow cytometry. The autoimmune responses in Treg cell-specific heterozygous Cdc42 knockout mice, CASIN-treated C57BL/6 mice, and control mice were assessed by H&E staining and ELISA. Antitumor T-cell immunity in Treg cell-specific heterozygous Cdc42 knockout mice, CASIN-treated C57BL/6 mice, humanized NSGS mice, and control mice was assessed by challenging the mice with MC38 mouse colon cancer cells, KPC mouse pancreatic cancer cells, or HCT116 human colon cancer cells.ResultsTreg cell-specific heterozygous deletion or pharmacological targeting of Cdc42 with CASIN does not affect Treg cell numbers but induces Treg cell instability, leading to antitumor T-cell immunity without detectable autoimmune reactions. Cdc42 targeting causes an additive effect on immune checkpoint inhibitor anti-programmed cell death protein-1 antibody-induced T-cell response against mouse and human tumors. Mechanistically, Cdc42 targeting induces Treg cell instability and unleashes antitumor T-cell immunity through carbonic anhydrase I-mediated pH changes.ConclusionsRational targeting of Cdc42 in Treg cells holds therapeutic promises in cancer immunotherapy.
Evidence of Crowding on Russell 3000 Reconstitution Events
Authors: Micheli Alessandro , Neuman Eyal 
Published: November 2022

We develop a methodology which replicates in great accuracy the FTSE Russell indexes reconstitutions, including the quarterly rebalancings due to new initial public offerings (IPOs). While using only data available in the CRSP US Stock database for our index reconstruction, we demonstrate the accuracy of this methodology by comparing it to the original Russell US indexes for the time period between 1989 and 2019. A python package that generates the replicated indexes is also provided [A Micheli. pyndex — Russell index reconstruction package. Available at https: //github.com/alemicheli/pyndex .]. As an application, we use our index reconstruction protocol to compute the permanent and temporary price impact on the Russell 3000 annual additions and deletions, and on the quarterly additions of new IPOs. We find that the index portfolios following the Russell 3000 index and rebalanced on an annual basis are overall more crowded than those following the index on a quarterly basis. This phenomenon implies that transaction costs of indexing strategies could be significantly reduced by buying new IPOs additions in proximity to quarterly rebalance dates.
Forty-five years of joint research programmes on geological disposal of radioactive waste and the pioneering role of the HADES Underground Research Laboratory
Authors: Hassine Seif Ben Hadj , Davies Christophe , Garbil Roger 
Published: November 2022

Abstract
Since 1975, the European Commission has supported research in the field of radioactive waste management and geological disposal through the Euratom Research and Training Programme. During the first two community programmes (1975–85), the research activities focused on basic knowledge, feasibility and safety assessments of such geological disposal repositories. It was during this first decade of collaborative research activities that the site characterization, preliminary design studies and the application for authorization to construct the first underground research laboratory, the High Activity Disposal Experimental Site facility, took place.
Strange Bedfellows?
Authors: Mazur Eric Michael 
Published: November 2022

Abstract
At the end of the nineteenth century, revolutions in button technology, campaign, finance, and the make-up and role of religion in American society, justified the use of, the button to appeal to voters of different communities, even religious communities, broadly speaking. At the end of the twentieth century, revolutions in digital technology, campaign finance, and the place and role of religion in American culture again, transformed how U.S. presidential campaign buttons represented religion. The first transformations facilitated the commodification of the votes, justifying the expenditure, of large amounts of money on media technology to secure them. The second, transformations facilitated the commodification of the candidates, justifying the use of, technology and religion to raise funds for the campaign. Rather than serving as the, signpost to identify the voter, religion became the message to attract the consumer.