bluuebunny/crossref_metadata_2025_split huggingface dataset:
The libidinal body in community-based education: Evidence of somaesthetics from Borneo's Dayaknese communities
Authors: Sugiharto Setiono 
Published: December 2022

Abstract
Amidst the lingering prominence of idealist and rationalist traditions in the philosophy of education, the notion of living, sentient body (or soma) seems to have received scant attention by educational philosophers hitherto. These traditions—whose strong influence can be traced back to such philosophers as Plato, Descartes, Leibniz and Wolff—elevate and privilege the import of reasoning and mind over the body, rendering the latter ancillary and even distorting to the pursuit of knowledge and truth. Drawing on the idea of somaestehtic philosophy initially proposed by Richard Shusterman, this article first discusses this philosophical outlook and then expands it by foregrounding the notion of the libidinal body—that is, the potentiality of the performative dimension of the soma in constructing and reconstructing knowledge. It argues that the soma itself is, in fact, the site of desire for knowledge production and reproduction. To buttress this argument, the article provides evidence from Borneo's Dayaknese communities as one of the instances of the somatic society where the practices of the libidinal body for the community's education are most conspicuous. The article ends with some thoughts on the possible research directions the philosophy of education ought to take to push the field forward in its pursuit for virtue and the good life.
The riskiness of outstanding mortgages in the United States, 1999–2019
Authors: Larson William D. 
Published: December 2022

AbstractThis article introduces measures of credit risk for all outstanding mortgages in the United States between 1999 and 2019. Terminations play a fundamental role in offsetting risk introduced by new originations because of refinance activity and the often dual nature of home buyers as concurrent sellers. To illustrate these concepts in a policy setting, I show that the Home Affordable Refinance Program increased origination risk metrics but reduced overall risk due to associated terminations of even riskier loans. In addition to these flow dynamics, amortization, loan age, collateral appreciation, and prior selection drive changes to portfolio‐level risk.
Fortification by design: A rational approach to designing vitamin D delivery systems for foods and beverages
Authors: Maurya Vaibhav Kumar , Shakya Amita , Bashir Khalid , Jan Kulsum , McClements David Julian 
Published: December 2022

AbstractOver the past few decades, vitamin D deficiency has been recognized as a serious global public health challenge. The World Health Organization has recommended fortification of foods with vitamin D, but this is often challenging because of its low water solubility, poor chemical stability, and low bioavailability. Studies have shown that these challenges can be overcome by encapsulating vitamin D within well‐designed delivery systems containing nanoscale or microscale particles. The characteristics of these particles, such as their composition, size, structure, interfacial properties, and charge, can be controlled to attain desired functionality for specific applications. Recently, there has been great interest in the design, production, and application of vitamin‐D loaded delivery systems. Many of the delivery systems reported in the literature are unsuitable for widespread application due to the complexity and high costs of the processing operations required to fabricate them, or because they are incompatible with food matrices. In this article, the concept of “fortification by design” is introduced, which involves a systematic approach to the design, production, and testing of colloidal delivery systems for the encapsulation and fortification of oil‐soluble vitamins, using vitamin D as a model. Initially, the challenges associated with the incorporation of vitamin D into foods and beverages are reviewed. The fortification by design concept is then described, which involves several steps: (i) selection of appropriate vitamin D form; (ii) selection of appropriate food matrix; (iii) identification of appropriate delivery system; (iv) identification of appropriate production method; (vii) establishment of appropriate testing procedures; and (viii) system optimization.
Induction of vascular endothelial growth factor‐A165a in human retinal and endothelial cells in response to glyoxal
Authors: Morawietz Henning , Frenzel Annika , Mieting Alice , Goettsch Winfried , Valtink Monika , Roehlecke Cora , Jászai József , Funk Richard H. W. , Becker Klio A. , Engelmann Katrin 
Published: December 2022

AbstractLow‐density lipoprotein (LDL) apheresis is effective and safe for patients with diabetes, proteinuria, and dyslipidemia. Diabetes mellitus is accompanied by ocular microvascular complications like retinal neovascularization or diabetic macular edema. These are leading causes of blindness and can be mediated by abnormal vessel growth and increased vascular permeability due to elevated levels of vascular endothelial growth factor (VEGF) in diabetic patients. In this study, we established methods to study the expression of different VEGF isoforms in human retinal and endothelial cells. The VEGF‐A165a isoform is much higher expressed in retinal cells, compared to endothelial cells. Stimulation with glyoxal as a model of oxidative stress under diabetic conditions lead to a pronounced induction of VEGF‐A165a in human retinal and endothelial cells. These data suggest that diabetes and oxidative stress induce VEGF‐A isoforms which could be relevant in regulating the ingrowths of novel blood vessels into the retina in diabetic patients.
Therapeutic plasma exchange in the intensive care unit: Rationale, special considerations, and techniques for combined circuits
Authors: Sanchez Amber P. , Ward David M. , Cunard Robyn 
Published: December 2022

AbstractTherapeutic plasma exchange (TPE) is an extracorporeal blood purification technique with proven efficacy in a variety of conditions, including in the intensive care setting. It is not uncommon for a critically ill patient to require more than one extracorporeal procedure in addition to TPE. This review focuses on the combination of TPE with other extracorporeal circuits in a critical care setting via a single vascular access (either in‐series, parallel, or a hybrid mode) which is often referred to as performing procedures “in tandem.” Authors performed literature review via pubmed.gov using search terms: plasma exchange, plasmapheresis, apheresis, tandem circuits, combined circuits, critical care, ICU, CRRT, hemodialysis, and ECMO. Thirty‐eight English‐language, peer‐reviewed papers were appraised that satisfied the content of this review on techniques for combining circuits with plasma exchange, as well as describing the advantages of tandem procedures and potential complications that can arise. Performing these procedures simultaneously can be advantageous in reducing total procedure and staffing time, avoiding placement of additional central lines, reducing overall need for anticoagulation, and limiting multiple blood primes in certain populations. However, the described combined circuits are complex, associated with higher complications, and require a skilled team to understand and mitigate the potential complications associated with these combined procedures.
Pregnancy in homozygous familial hypercholesterolemia—A case series
Authors: Bláha Milan , Veletová Kateřina , Blaha Vladimír , Lánská Miriam , Žák Pavel 
Published: December 2022

AbstractIntroductionFamilial hypercholesterolemia (FH) is an autosomal codominant lipid metabolism disorder. It results in lifelong elevation of plasmatic low‐density lipoprotein cholesterol (LDL‐C) levels, followed by premature atherosclerosis. In women, pregnancy and lactation represent an additional risk due to association of physiological changes, pre‐existing dyslipidemia, and limited therapeutic possibilities and experiences. Methods of extracorporeal LDL‐apheresis represent a suitable therapeutic approach.Case seriesWe present our experience in case reports of six HoFH women and their 13 pregnancies (nine successful, three abortions, and one interruption). One patient experienced a lethal complication of her pregnancy. Of the nine successful pregnancies, two cases were treated by LDL‐apheresis.ConclusionPregnancy in HoFH women represents substantial risk; however, patients without signs of decompensated cardiovascular disease can have a good prognosis. LDL‐apheresis plays an important role in the management of pregnancy in HoFH.
Complementary role of evinacumab in combination with lipoprotein apheresis in patients with homozygous familial hypercholesterolemia
Authors: Duell Paul Barton , Warden Bruce A. 
Published: December 2022

AbstractPatients with homozygous familial hypercholesterolemia (FH) have severe hypercholesterolemia from birth and if untreated may experience very early onset of coronary artery disease in childhood or young adulthood with an aggressive course resulting in early death. Early initiation of aggressive low‐density lipoprotein cholesterol (LDL‐C) lowering is the mainstay of treatment, which requires the use of a multidrug treatment regimen, often in combination with lipoprotein apheresis, but LDL‐C goal achievement is frequently unattainable due to the severity of baseline hypercholesterolemia and hyporesponsiveness to many LDL‐C‐lowering medications. Evinacumab, a monoclonal antibody that sequesters angiopoietin‐like 3 protein and lowers LDL‐C by an average of 49% in patients with homozygous FH, was approved by the Food and Drug Administration in February 2021 and is a major advance in treatment of these high‐risk patients. In this report, we describe the complementary role of evinacumab in combination with lipoprotein apheresis in two patients with homozygous FH.
Microwave‐assisted enzymatic extraction brings a notably high yield of polysaccharides from mountain Zizania latifolia
Authors: Zhang Yang , Liu Xinyue , Wang Ziteng , Sha Yueshi , Zhang Shushu , Xu Hai , Bai Yun , Liu Jiangyun , Yan Zhaowei 
Published: December 2022

AbstractMountain Zizania latifolia is produced at scale in China, and the edible swollen culm is exported to many countries, but little attention has been paid to its functional components. In this work, microwave‐assisted enzymatic extraction (MAEE) is used for the first time to extract polysaccharides from mountain Z. latifolia swollen culm (PMZL). MAEE conditions optimized by Box–Behnken design‐response surface methodology were as follows: 2.4% cellulase, microwaving for 6.0 min at 607 W, with a liquid‐to‐solid ratio of 63:1 ml g−1. Under these conditions, a notably high yield of 60.43% ± 1.12% for PMZL was achieved, which was significantly higher (p < 0.01) than from plain‐grown varieties. PMZL are naturally occurring sulfated polysaccharide–protein complexes containing 8.46% ± 0.18% proteins and 7.86% ± 0.73% sulfates. PMZL comprises mannose, glucosamine, rhamnose, glucose, galactose, and arabinose at molar ratios of 3.80:2.68:1.00:17.41:5.12:2.91, with a weight‐average molecular weight of 1569,219 Da and a number‐average molecular weight of 364,088 Da. The surface morphology of PMZL is composed of tightly packed oval particles, and this kind of promising polysaccharides preferentially scavenges reactive nitrogen species.Practical ApplicationDue to global warming, the land available for planting vegetables is likely to expand to higher areas, so greater attention should now be paid to mountain‐grown vegetables. This study provides an efficient way to obtain novel polysaccharides from mountain Zizania latifolia using microwave‐assisted enzymatic extraction with a remarkably high yield of 60.4%. This promising source of natural carbohydrates has potential uses in pharmaceutical, nutraceutical, functional foods, cosmetics, and functional materials industries.
Marinobacter: A case study in bioelectrochemical chassis evaluation
Authors: Bird Lina J. , Mickol Rebecca L. , Eddie Brian J. , Thakur Meghna , Yates Matthew D. , Glaven Sarah M. 
Published: December 2022

AbstractThe junction of bioelectrochemical systems and synthetic biology opens the door to many potentially groundbreaking technologies. When developing these possibilities, choosing the correct chassis organism can save a great deal of engineering effort and, indeed, can mean the difference between success and failure. Choosing the correct chassis for a specific application requires a knowledge of the metabolic potential of the candidate organisms, as well as a clear delineation of the traits, required in the application. In this review, we will explore the metabolic and electrochemical potential of a single genus,Marinobacter.We will cover its strengths, (salt tolerance, biofilm formation and electrochemical potential) and weaknesses (insufficient characterization of many strains and a less developed toolbox for genetic manipulation) in potential synthetic electromicrobiology applications. In doing so, we will provide a roadmap for choosing a chassis organism for bioelectrochemical systems.
Leveraging substrate flexibility and product selectivity of acetogens in two‐stage systems for chemical production
Authors: Ricci Luca , Seifert Arne , Bernacchi Sebastien , Fino Debora , Pirri Candido Fabrizio , Re Angela 
Published: December 2022

AbstractCarbon dioxide (CO2) stands out as sustainable feedstock for developing a circular carbon economy whose energy supply could be obtained by boosting the production of clean hydrogen from renewable electricity. H2‐dependent CO2 gas fermentation using acetogenic microorganisms offers a viable solution of increasingly demonstrated value. While gas fermentation advances to achieve commercial process scalability, which is currently limited to a few products such as acetate and ethanol, it is worth taking the best of the current state‐of‐the‐art technology by its integration within innovative bioconversion schemes. This review presents multiple scenarios where gas fermentation by acetogens integrate into double‐stage biotechnological production processes that use CO2 as sole carbon feedstock and H2 as energy carrier for products' synthesis. In the integration schemes here reviewed, the first stage can be biotic or abiotic while the second stage is biotic. When the first stage is biotic, acetogens act as a biological platform to generate chemical intermediates such as acetate, formate and ethanol that become substrates for a second fermentation stage. This approach holds the potential to enhance process titre/rate/yield metrics and products' spectrum. Alternatively, when the first stage is abiotic, the integrated two‐stage scheme foresees, in the first stage, the catalytic transformation of CO2 into C1 products that, in the second stage, can be metabolized by acetogens. This latter scheme leverages the metabolic flexibility of acetogens in efficient utilization of the products of CO2 abiotic hydrogenation, namely formate and methanol, to synthesize multicarbon compounds but also to act as flexible catalysts for hydrogen storage or production.
Microbial antibiotics take the lead in the fight against plant pathogens
Authors: Roca Amalia , Matilla Miguel A. 
Published: December 2022

AbstractThe plant microbiome is essential for plant fitness and health. Antibiotics produced by plant‐associated bacteria have been shown to play an important role in protecting plant hosts against phytopathogens. Here, we highlight the strong biotechnological potential of (i) antibiotic producing plant‐associated bacteria as biocontrol agents and (ii) the heterologous expression of antibiotic biosynthetic gene clusters in non‐pathogenic plant‐associated bacteria. We also provide the complete list of the active substances based on bacteria, fungi, and viruses currently approved or pending approval in the European Union, as an indication of the significant emergence and biotechnological applicability of biopesticides. Further progress in this field of research will enable the development of novel biopesticides for the biocontrol of agricultural pests.
Development of a live biotherapeutic throat spray with lactobacilli targeting respiratory viral infections
Authors: Spacova Irina , De Boeck Ilke , Cauwenberghs Eline , Delanghe Lize , Bron Peter A. , Henkens Tim , Simons Alix , Gamgami Imane , Persoons Leentje , Claes Ingmar , van den Broek Marianne F. L. , Schols Dominique , Delputte Peter , Coenen Samuel , Verhoeven Veronique , Lebeer Sarah 
Published: December 2022

AbstractRespiratory viruses such as influenza viruses, respiratory syncytial virus (RSV), and coronaviruses initiate infection at the mucosal surfaces of the upper respiratory tract (URT), where the resident respiratory microbiome has an important gatekeeper function. In contrast to gut‐targeting administration of beneficial bacteria against respiratory viral disease, topical URT administration of probiotics is currently underexplored, especially for the prevention and/or treatment of viral infections. Here, we report the formulation of a throat spray with live lactobacilli exhibiting several in vitro mechanisms of action against respiratory viral infections, including induction of interferon regulatory pathways and direct inhibition of respiratory viruses. Rational selection ofLactobacillaceaestrains was based on previously documented beneficial properties, up‐scaling and industrial production characteristics, clinical safety parameters, and potential antiviral and immunostimulatory efficacy in the URT demonstrated in this study. Using a three‐step selection strategy, three strains were selected and further tested in vitro antiviral assays and in formulations:Lacticaseibacillus caseiAMBR2 as a promising endogenous candidate URT probiotic with previously reported barrier‐enhancing and anti‐pathogenic properties and the two well‐studied model strainsLacticaseibacillus rhamnosusGG andLactiplantibacillus plantarumWCFS1 that display immunomodulatory capacities. The three strains and their combination significantly reduced the cytopathogenic effects of RSV, influenza A/H1N1 and B viruses, and HCoV‐229E coronavirus in co‐culture models with bacteria, virus, and host cells. Subsequently, these strains were formulated in a throat spray and human monocytes were employed to confirm the formulation process did not reduce the interferon regulatory pathway‐inducing capacity. Administration of the throat spray in healthy volunteers revealed that the lactobacilli were capable of temporary colonization of the throat in a metabolically active form. Thus, the developed spray with live lactobacilli will be further explored in the clinic as a potential broad‐acting live biotherapeutic strategy against respiratory viral diseases.
Spectrum of intracranial and spinal epidermoids including unusual locations and imaging findings: A pictorial review
Authors: Nitheesha Reddy Vendoti , Nagarajan Krishnan , Midhusha Reddy Vendoti , Amuthabharathi Mohan , Gopalakrishnan Madhavan S , Ramesh Andi S 
Published: December 2022

AbstractIntracranial and spinal epidermoids are benign slow‐growing congenital lesions. They are predominantly intradural, extra‐axial in location, with intra‐axial locations (intra‐parenchymal and spinal intramedullary) being rare. The most common locations of intradural epidermoids are cerebellopontine angle cistern followed by supra‐ and para‐sellar regions, and fourth ventricle. Less common locations include inter‐hemispheric fissure, sylvian fissure, lateral ventricle, intracerebral, velum interpositum cistern, superior cerebellar cistern and pineal gland. They can also be extradural, usually arising in the diploic space of the calvaria, though they are less common. Magnetic resonance imaging is the primary modality for diagnosis and knowing the extent of the lesion. In this pictorial review, we intend to illustrate their classical and unusual locations, atypical imaging findings including calcifications, rare complications like haemorrhage or spontaneous rupture.
Global ocean governance in the Anthropocene: From extractive imaginaries to planetary boundaries?
Authors: Stephens Tim 
Published: December 2022

AbstractAs with other fields of international law addressing human‐nature relations, the Anthropocene invites the reappraisal and reimagining of the law of the sea, the primary normative framework through which states regulate access to, and the use of, the global ocean. The UN Convention on the Law of the Sea (UNCLOS) effected a major shift in global ocean governance towards a public order of the seas. However, the law of the sea remains substantially tethered to a Holocene conception of the ocean as a stable environmental domain of extractive exploitation and jurisdictional demarcation. This is illustrated by the confined scope of negotiations on a new implementing agreement under UNCLOS on the conservation and use of marine biodiversity beyond national jurisdiction. Additionally, there has been limited acknowledgment of the multiple sites at which ocean governance in the Anthropocene takes place, in particular the central role of the UN Framework Convention on Climate Change (UNFCCC) and the Paris Agreement on Climate Change. It is contended that one way forward for addressing both these conceptual constraints and the UNCLOS and UNFCCC regime coordination challenges is the adoption of global ocean governance goals informed by the ‘Planetary Boundaries’ framework.
Comparative analysis of electromagnetic navigation bronchoscopy versus computed tomography‐guided lung puncture for the sampling of indeterminate pulmonary nodules in the middle of an anatomic lung segment: A cohort study
Authors: Zhang Shuliang , Guo Feilong , Wang Hongjin , Chen Maohui , Huang Guanglei , Zhu Yong , Zheng Wei , Zheng Bin , Chen Chun 
Published: December 2022

AbstractBackgroundTo compare the diagnostic positive rate and complication rate between the electromagnetic navigation bronchoscopy (ENB) technique and computed tomography (CT)‐guided lung puncture for the biopsy of lung nodules located in the middle of an anatomic lung segment.MethodsElectronic medical records of 114 patients who underwent lung nodule biopsy between June 2021 and June 2022 were retrospectively evaluated. In all patients, the nodules were located in the middle third lung segment. To compare the diagnostic positive and complication rates between the two biopsy modalities performed in this lung region, clinical data, complication rates, nodule pathology, and imaging results were reviewed based on nodule characteristics retrieved from the electronic medical records.ResultsNinety‐three patients underwent CT‐guided lung puncture, while the remaining 21 patients underwent the ENB technique. No significant difference was observed in the diagnostic positive rate between the two groups (73.6 and 76.1%, respectively). In the CT‐guided lung puncture group, pneumothorax incidence, tube placement, postoperative hemorrhage, and symptomatic hemorrhage rates were 16.1, 6.5, 6.5, and 1.1%, respectively. In contrast, no complications occurred in the ENB group.ConclusionsThe ENB technique is a safe and effective method for performing biopsies of pulmonary nodules with a diagnostic positive rate comparable to that of CT‐guided lung puncture and with a lower postoperative complication rate.