bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyaniline based polymers in tissue engineering applications: a review
Authors: Rai Ranjana , Roether Judith A , Boccaccini Aldo R 
Published: September 2022

Abstract
A number of electrically conducting polymers, such as polyaniline (PANi), as well as functionalized aniline copolymers and composites, which are simultaneously biodegradable and conductive, have been applied for developing electrically conductive scaffolds for tissue engineering (TE) in recent years. The rationale behind these scaffolds is to induce ‘electroactivity’ in scaffolds, as many research works have shown that an intrinsic electrical activity leads to both increased regeneration rates and improved healing of damaged tissues. PANi is the conductive polymer of choice because it is economical and easy to process with a variety of methods. The resultant PANi based biomaterials have shown biocompatibility, conductivity, suitable processability, positive cellular response, as well as an intrinsic antibacterial effect in numerous research studies. The analysis of the literature has revealed that PANi based scaffolds have been investigated for TE applications including skin/wound healing, bone, cartilage, nerve/spinal cord, vascular, skeletal muscle repair and for the treatment of infertility. Although PANi based materials find widespread applications in other sectors, they are still far away from being commercially exploited as scaffolds for TE despite positive research results. This review aims to discuss and critically assess the current state of PANi based TE scaffolds for different applications. A future perspective for utilizing PANi based biomaterials for applications in TE is discussed, including recent considerations about potential cytotoxic effects.
Modelling and statistical analysis of emotions in 3D space
Authors: Garg Divya , Verma Gyanendra Kumar , Singh Awadhesh Kumar 
Published: September 2022

Abstract
Emotional Intelligence provides an impetus for simulating human emotions in systems to make emotionally-sensitive machines. Integrating emotion-based theories and principles maturing with research in affective computing, we propose a novel statistical approach that can evaluate the correlation between different emotional states. It provides a way specialists can address the development of the entire passion experience, as reviewed through self-report. We also represent a three-dimensional model that can accommodate affect variabilities and analyze the distribution of affective states in valence, arousal, and dominance. The main idea is that human emotions can be quantified by measuring their degree of emotions. To the best of our knowledge, this is the first step in this direction, and we have proposed and successfully implemented it to induce feelings in robots and games.
Maternal Health, Pregnancy and Offspring Factors, and Maternal Thyroid Cancer Risk: A Nordic Population-Based Registry Study
Authors: Kitahara Cari M , Slettebø Daltveit Dagrun , Ekbom Anders , Engeland Anders , Gissler Mika , Glimelius Ingrid , Grotmol Tom , Trolle Lagerros Ylva , Madanat-Harjuoja Laura , Männistö Tuija , Sørensen Henrik Toft , Troisi Rebecca , Bjørge Tone 
Published: September 2022

Abstract
Thyroid cancer incidence is higher in women than men, especially during the reproductive years, for reasons that remain poorly understood. Using population-based registry data from 4 Nordic countries through 2015, we examined associations of perinatal characteristics with risk of maternal thyroid cancer. Cases were women diagnosed with thyroid cancer ≥2 years after last birth (n = 7,425, 83% papillary). Cases were matched to controls (n = 67,903) by mother’s birth year, country, and county of residence. Odds ratios (ORs) were estimated using conditional logistic regression models adjusting for parity. Older age at first pregnancy, postpartum hemorrhage (OR = 1.18, 95% (confidence interval) CI: 1.08, 1.29), and benign thyroid conditions (ORs ranging from 1.64 for hypothyroidism to 10.35 for thyroid neoplasms) were associated with increased thyroid cancer risk, as were higher offspring birth weight (per 1-kg increase, OR = 1.17, 95% CI: 1.12, 1.22) and higher likelihood of offspring being large for gestational age (OR = 1.26, 95% CI: 1.11, 1.43). Unmarried/noncohabiting status (OR = 0.91, 95% CI: 0.84, 0.98), maternal smoking (OR = 0.75, 95% CI: 0.67, 0.84), and preterm birth (OR = 0.90, 95% CI: 0.83, 0.98) were associated with reduced risk. Several factors (e.g., older age at first pregnancy, maternal smoking, goiter, benign neoplasms, postpartum hemorrhage, hyperemesis gravidarum, and neonatal jaundice) were associated with advanced thyroid cancer. These findings suggest that some perinatal exposures may influence maternal thyroid cancer risk.
Effects of habitat disturbance on the reproductive ecology of Arum pictum ssp. sagittifolium: from pollination to seedling recruitment
Authors: Borràs Joshua , Lázaro Amparo , González-Estévez Miguel A , Cursach Joana 
Published: September 2022

Abstract

Background and Aims
The loss of natural habitats may strongly affect the fitness of plants that depend on animals for reproduction. However, very little is known regarding the differential effects of habitat disturbance on the distinct phases of the reproductive cycle of plants, especially in non-rewarding species.

Methods
We assessed the effects of habitat disturbance on the entire reproductive cycle of Arum pictum ssp. sagittifolium, a species with deceptive pollination that is endemic to the western Mediterranean Basin. For this, we performed hand-pollination and bagging experiments, evaluated the role of pollinators and dispersers on reproduction, and estimated seedling recruitment in three natural and three disturbed populations (according to their surrounding natural habitat) in Mallorca Island.

Key Results
Pollinators were sphaerocerid flies (mainly Coproica, with ~50 % of visits) and staphylinid beetles, and were required for sexual reproduction. Habitat disturbance differently affected the reproductive phases of A. pictum ssp. sagittifolium. Habitat disturbance had a positive effect on Shannon pollinator diversity (but not on pollinator richness), and total pollinator and Coproica abundance were three times higher in disturbed habitats, where overall seed production was also ~30 % higher in natural habitats. Seed production increased with Coproica abundance, but only in natural habitats. Seed dispersers of A. pictum ssp. sagittifolium were birds, mainly Sylvia atricapilla. Although habitat disturbance did not influence disperser diversity or abundance, the majority of seedlings appeared under adult plants and in natural habitats.

Conclusions
Overall recruitment was higher in natural habitats, but this effect could have been masked by only assessing pollinator and disperser numbers, as processes related to the quality of these interactions might be influencing fitness. Our study highlights the need to study different reproductive phases and their multiple components and processes to properly understand the effects of habitat disturbance on the regeneration of plant populations.
Writing Trajectories of Grammatical Complexity at the University: Comparing L1 and L2 English Writers in BAWE
Authors: Staples Shelley , Gray Bethany , Biber Douglas , Egbert Jesse 
Published: September 2022

AbstractGrammatical complexity has been established as a key indicator of language and writing development (Ortega 2003; Bulté and Housen, 2014; Crossley and McNamara 2014). The present study uses the Register-Functional approach to complexity (Biber et al. 2022) to compare the development of L1 English and L2 English writers across year of study and discipline in the British Academic Written English corpus. It also introduces a novel method of examining developmental trajectories that uses both inferential statistics and descriptive measures to account not only for relationships between the year of study and use of linguistic features, but also for the shape of the trajectories and frequencies of occurrence over time. Statistical analyses reveal significant relationships for most of the complexity features. Means and confidence intervals indicate overall similarities in trends from early undergraduate to graduate-level writing across L1/L2 English writers, but also key differences in the developmental trajectories, including greater use of phrasal complexity features and less use of clausal features by L2 English writers in early levels, as well as distinct use of complexity features across certain disciplines.
Detection and characterization of new mangromicin analogs by tandem mass spectrometry
Authors: Kamiya Yoshiyuki , Nakashima Takuji , Taniguchi Takako , Takahashi Yōko , Ōmura Satoshi , Taniguchi Hisaaki 
Published: September 2022

ABSTRACTMany useful natural products are usually screened based on their biological activities. On the other hand, various natural products can be detected based on their physicochemical properties. We have already reported the isolation and characterization of mangromicins from a cultural broth of Lechevalieria aerocolonigenes K10-0216 using physicochemical screening. In this report, we have conducted the mass spectrometry-based screening of new mangromicin analogs based on the neutral loss pattern originated from the unique cyclopentadecane skeleton of mangromicins. Two novel analogs were detected showing characteristic neutral loss pattern found in eight known mangromicin analogs. We propose the structures of the newly-found analogs based on the mass spectrometric as well as genomic and metabolic pathway data.
Monks relax sibling competition over parental resources in Tibetan populations
Authors: Zhou Liqiong , Ge Erhao , Micheletti Alberto J C , Chen Yuan , Du Juan , Mace Ruth 
Published: September 2022

AbstractWhy parents in some societies induce some of their sons to become religious celibates is an evolutionary puzzle. Some have speculated that this might be associated with brother competition for family resources. However, the behavioral ecology of monks and the possible links with competition between brothers remain unexplored. Here, we use demographic data from Amdo Tibetan agropastoralists in western China to evaluate what factors determine the probability of becoming a monk and explore the possible association between wealth and having a monk brother. We found that boys with at least one older brother are more likely to become celibate monks. Patrilocal heads of household, who inherit parental property, are more likely to be first-born sons, whereas men who marry uxorilocally, that is they move to their wife’s household, are generally second- or later-born sons. Moreover, we find that men with at least one monk brother are wealthier than men who only have non-celibate brothers. Together, these results suggest that sending a son to the monastery is a way for parents to decrease competition between brothers over family resources. Harsh and resource-limited environments, like the one we consider, can lead to the emergence of communal households, including polyandrous families, which used to be common in Tibetan areas. Directing one son to become a religious celibate offers a potentially effective solution to brother competition in our population.
Deep learning models for disease-associated circRNA prediction: a review
Authors: Chen Yaojia , Wang Jiacheng , Wang Chuyu , Liu Mingxin , Zou Quan 
Published: September 2022

Abstract
Emerging evidence indicates that circular RNAs (circRNAs) can provide new insights and potential therapeutic targets for disease diagnosis and treatment. However, traditional biological experiments are expensive and time-consuming. Recently, deep learning with a more powerful ability for representation learning enables it to be a promising technology for predicting disease-associated circRNAs. In this review, we mainly introduce the most popular databases related to circRNA, and summarize three types of deep learning-based circRNA-disease associations prediction methods: feature-generation-based, type-discrimination and hybrid-based methods. We further evaluate seven representative models on benchmark with ground truth for both balance and imbalance classification tasks. In addition, we discuss the advantages and limitations of each type of method and highlight suggested applications for future research.
Uniparentality: advantages for range expansion in diploid and diploid-autopolyploid species
Authors: Reutemann A Verena , Martínez Eric J , Schedler Mara , Daviña Julio R , Hojsgaard Diego H , Honfi Ana I 
Published: September 2022

AbstractUniparental reproduction, the capacity of an individual to produce offspring autonomously, is expected to facilitate range expansion of populations. Paspalum spp. reproduce uniparentally by sexual (self-fertility) and asexual (apomixis) reproduction and biparentally by sexual (self-sterility) reproduction. We evaluated the relationship between contrasting reproductive strategies (uni- and biparentality) and their impact on the colonizing ability and geographical range sizes of populations. We determined the cytotype composition of 16 populations of P. indecorum, P. cromyorhizon, P. pumilum and P. maculosum and assessed the sexual (self-fertile and self-sterile) and apomictic proportions by cyto-embryological analyses, fertility rates and seed flow cytometry. Data obtained regarding reproductive modes were compared to the distribution range of each cytotype and species. Sexual diploids with moderate degrees of self-fertility and mixed pollination syndromes showed wider distribution ranges than self-sterile diploids. In sexual diploids, increased rates of self-fertility relate to larger distribution areas. In agamic complexes, self-fertility reduces the differences in range sizes between biparental diploids and uniparental tetraploids. In such complexes, the range size of diploid cytotypes explains the range size and dispersal of apomictic tetraploids. Thus, uniparental reproduction via self-fertility and apomixis describes patterns of geographical parthenogenesis in South American species.
Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma
Authors: Laraba Liyam , Hillson Lily , de Guibert Julio Grimm , Hewitt Amy , Jaques Maisie R , Tang Tracy T , Post Leonard , Ercolano Emanuela , Rai Ganesha , Yang Shyh-Ming , Jagger Daniel J , Woznica Waldemar , Edwards Philip , Shivane Aditya G , Hanemann C Oliver , Parkinson David B 
Published: September 2022

AbstractSchwannoma tumours typically arise on the eighth cranial nerve and are mostly caused by loss of the tumour suppressor Merlin (NF2). There are no approved chemotherapies for these tumours and the surgical removal of the tumour carries a high risk of damage to the eighth or other close cranial nerve tissue. New treatments for schwannoma and other NF2-null tumours such as meningioma are urgently required.Using a combination of human primary tumour cells and mouse models of schwannoma, we have examined the role of the Hippo signalling pathway in driving tumour cell growth. Using both genetic ablation of the Hippo effectors YAP and TAZ as well as novel TEAD palmitoylation inhibitors, we show that Hippo signalling may be successfully targeted in vitro and in vivo to both block and, remarkably, regress schwannoma tumour growth. In particular, successful use of TEAD palmitoylation inhibitors in a preclinical mouse model of schwannoma points to their potential future clinical use. We also identify the cancer stem cell marker aldehyde dehydrogenase 1A1 (ALDH1A1) as a Hippo signalling target, driven by the TAZ protein in human and mouse NF2-null schwannoma cells, as well as in NF2-null meningioma cells, and examine the potential future role of this new target in halting schwannoma and meningioma tumour growth.
Less Is More? Antibiotic Treatment Duration inPseudomonas aeruginosaVentilator-Associated Pneumonia
Authors: Albin Owen R , Kaye Keith S , McCreary Erin K , Pogue Jason M 
Published: September 2022

AbstractRecommended antimicrobial treatment durations for ventilator-associated pneumonia (VAP) caused by Pseudomonas aeruginosa have evolved over the past few decades. In this Viewpoint, we provide a narrative review of landmark trials investigating antimicrobial treatment durations for VAP caused by P. aeruginosa, and appraise iterations of expert consensus guidelines based on these data. We highlight strengths and weaknesses of existing data on this topic and provide recommendations for future avenues of study.
Crisis and state transformation: Covid-19, levelling up and the UK’s incoherent state
Authors: Richards David , Warner Sam , Smith Martin J , Coyle Diane 
Published: September 2022

AbstractThis article provides a novel account of recent UK governance reforms, describing what can be termed an ‘incoherent’ state, ill-equipped to address complex, multi-dimensional policy challenges. This is evidenced through two interrelated case-studies: Covid-19 and levelling up. We highlight how the tradition of strongly centralised government combined with an ad hoc approach to reform has undermined inter-governmental relations and limited the possibility of effective policy. We conclude by arguing that current levelling up proposals, focused on redesigning sub-national government, reflect these deficiencies and therefore offer an insufficient remedy for the UK’s imbalanced economic geography and resulting inequalities. The failure of past reform highlights the need for systemic transformation—including a new governance framework—to address meaningfully the UK’s geography of discontent.
Blood biochemistry and hematology of adult and chick brown pelicans in the northern Gulf of Mexico: baseline health values and ecological relationships
Authors: Jodice Patrick G R , Lamb Juliet S , Satgé Yvan G , Fiorello Christine 
Published: September 2022

Abstract
The northern Gulf of Mexico supports a diverse community of nearshore seabirds during both breeding and nonbreeding periods of the annual cycle and is also a highly industrialized marine ecosystem with substantial levels of oil and gas development particularly in the west and central regions. Stakeholders in the region often assess risk to species of interest based on these differing levels of development. We collected blood samples from 81 adult and 35 chick eastern brown pelicans (Pelecanus occidentalis carolinensis) from 10 colonies across the northern Gulf of Mexico and used these to establish baseline values for hematology and blood biochemistry. We assessed the potential influence of body condition, sex and home range size on hematology and blood biochemistry. We also assessed potential influences of oil and gas activity by considering differing levels of oil and gas development that occur regionally throughout the study area. Although blood analyte concentrations of adults and chicks were often associated with these regional differences, the pattern we observed was not entirely consistent with the differing levels of oil and gas activity across the Gulf, suggesting that regional levels of oil and gas activity around breeding sites may not be the primary drivers of hematology and blood biochemistry. We note that baseline values or reference intervals are not available for other nearshore seabirds that breed in the northern Gulf. Given that exposure and risk may differ among this suite of species based on diet, foraging strategies and life history strategies, similar assessments and monitoring may be warranted.
Perianal Crohn’s Disease and the Development of Colorectal and Anal Cancer: A Systematic Review and Meta-analysis
Authors: Johansen Martha Pollen , Wewer Mads Damsgaard , Nordholm-Carstensen Andreas , Burisch Johan 
Published: September 2022

AbstractBackground and AimsThe aim of this systematic review was to assess the literature on the incidence and risk factors for colorectal cancer and anal cancer in patients with perianal Crohn’s disease.MethodA systematic review of the literature was performed using PubMed, Embase and Google Scholar. A meta-analysis was then conducted using a random-effects model.ResultsFive studies were included in the systematic review. Of the total patients, 26.5% had perianal Crohn’s disease. The median follow-up was 6 years. In total, 127 cases of colorectal cancer were found [0.43% of the included Crohn’s disease patients]. Perianal involvement was present in 50% of colorectal cancer patients [0.89% of the population]. Three of the studies specified the cancer to be rectal or anal, which were present in 68 and 24 cases [0.3% and 0.1% of patients], respectively. In a subgroup analysis of rectal and anal cancer, perianal involvement was most frequent in anal cancer, accounting for 46% of the cases. In the rectal cancer group, 37% had perianal involvement. The higher incidence of colorectal cancer in patients with perianal Crohn’s disease was confirmed in a meta-analysis.ConclusionHalf of the patients with colorectal cancer and anal cancer were found to have perianal Crohn’s disease. In patients with perianal involvement, there was a higher percentage of anal cancer compared with rectal cancer. These results support the theory that patients with perianal Crohn’s disease are at increased risk for developing colorectal and anal cancer. Studies collecting more detailed data regarding patients and their cancers are needed to further specify the disease course.
Efficacy of Matrine, Rotenone, and Pyrethrin Against Red Imported Fire Ant Solenopsis invicta (Hymenoptera: Formicidae) and Their Impact on Aquatic Organisms
Authors: Liang Mingrong , Zhang Senquan , Zheng Xiaobin , Deng Jiefu , Yang Jiaqi , Liang Yuling , Li Zhiqiang , Yue Xinlu , Lu Yongyue , Xu Yijuan , Wang Lei 
Published: September 2022

Abstract
Chemicals, including toxic bait and dusts, are the main means of controlling the red imported fire ant Solenopsis invicta (abbreviation ‘RIFA’), which is a serious invasive pest. To identify environmentally friendly chemicals for controlling RIFA, we tested the toxicity and horizontal transfer of three botanical insecticides—matrine, rotenone, and pyrethrin—and their impact on aquatic organisms (i.e., three fish and one shrimp). The LD50 value of matrine, rotenone, and pyrethrin was 0.24, 50.929, and 13.590 ng/ant, respectively. Matrine, rotenone, and pyrethrin had effective horizontal transfer and caused significant secondary mortality. After exposure to donor workers, 90.75%, 90.75%, and 100% of recipient workers in the 0.025% matrine, 1.0% rotenone, and 0.3% pyrethrin dust treatments, respectively, died within 48 h. Furthermore, 0.025% matrine dust caused significant tertiary mortality (49.5%). Tertiary mortality caused by 1.0% rotenone and 0.3% pyrethrin dusts was very low, only 7.75% and 18.5%, respectively. In a field trial, the comprehensive mortality effect of 0.05% matrine, 1.50% rotenone, and 0.375% pyrethrin dust was 74.96%, 30.10%, and 29.27%, respectively, after 14 d of treatment. Matrine had low toxicity to the fish Hypophthalmichthys molitrix, and 37.5 mg/L pyrethrin had low toxicity to the fish Cirrhinus molitorella, H. molitrix, and Oreochromis niloticus. However, rotenone was highly toxic to all three fish. The shrimp Neocaridina denticulate was not sensitive to matrine, rotenone, or pyrethrin. Matrine dust has highly effective horizontal transfer, and 0.05% matrine dust has great potential for managing RIFA in organic farms, aquaculture farms of H. molitrix, and water resource regions.