bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of UGT1A1*6, UGT1A1*28, or ABCC2 c.3972C>T genetic polymorphisms with irinotecan‐induced toxicity in Asian cancer patients: Meta‐analysis
Authors: Atasilp Chalirmporn , Biswas Mohitosh , Jinda Pimonpan , Nuntharadthanaphong Nutthan , Rachanakul Jiratha , Hongkaew Yaowaluck , Vanwong Natchaya , Saokaew Surasak , Sukasem Chonlaphat 
Published: May 2022

AbstractEffects of UGT1A1*6 and UGT1A1*28 genetic polymorphisms on irinotecan‐induced severe toxicities in Asian cancer patients are inconclusive. Also, ABCC2 c.3972C>T may affect toxicity of irinotecan. The aim was to assess the aggregated risk of neutropenia or diarrhea in Asian cancer patients taking irinotecan and inherited UGT1A1*6, UGT1A1*28, or ABCC2 c.3972C>T genetic variants. A PubMed literature search for eligible studies was conducted. Odds ratios (ORs) were measured using RevMan software where p values <0.05 were statistically significant. Patients that inherited both UGT1A1*6 and UGT1A1*28 genetic variants (heterozygous: UGT1A1*1/*6 + *1/*28 and homozygous: UGT1A1*6/*6 + *28/*28) were significantly associated with increased risk of neutropenia and diarrhea compared to patients with UGT1A1*1/*1 (neutropenia: OR 2.89; 95% CI 1.97–4.23; p < 0.00001; diarrhea: OR 2.26; 95% CI 1.71–2.99; p < 0.00001). Patients carrying homozygous variants had much stronger effects in developing toxicities (neutropenia: OR 6.23; 95% CI 3.11–12.47; p < 0.00001; diarrhea: OR 3.21; 95% CI 2.13–4.85; p < 0.00001) than those with heterozygous variants. However, patients carrying the ABCC2 c.3972C>T genetic variant were not significantly associated with neutropenia (OR 1.67; 95% CI 0.98–2.84; p = 0.06) and were significantly associated with a reduction in irinotecan‐induced diarrhea (OR 0.31; 95% CI 0.11–0.81; p = 0.02). Asian cancer patients should undergo screening for both UGT1A1*6 and UGT1A1*28 genetic variants to reduce substantially irinotecan‐induced severe toxicities.
Labour Standards in Global Production Networks: Assessing Transnational Private Regulation and Workers’ Capacity to Act
Authors: Graz Jean‐Christophe , Sobrino Piazza Jimena , Walter André 
Published: May 2022

ABSTRACTDespite decades of growing engagement, there are still questions about the effectiveness of transnational private regulation in labour standards to improve employee welfare in global production networks. The literature shows that some improvement may be expected in outcome standards, such as benefits, working time, health and safety issues, but not necessarily in process rights, such as freedom of association, collective bargaining and employment dialogue. Yet, workers need such rights if they are to have a voice and to participate in the organizational processes by which standards may be improved and compliance monitored. The authors of this article contend that the effectiveness of transnational private regulation in labour standards ultimately rests on workers’ capacity to act. The article is based on analysis of a cross‐country and cross‐sectoral data set from site‐level surveys of 139 suppliers from Brazil and Kenya in the agricultural, manufacturing and service sectors. The analysis provides no evidence that either the presence of standards at a supplier's site, or the awareness of such standards by workers employed at that site, have an impact on workers’ capacity to act. Moreover, the results provide only weak evidence that standards help workers gain influence over matters of relatively minor importance on the agenda of workplace cooperation.
Global Groundwater Solute Composition and Concentrations
Authors: Wood Warren W. , Smedley Pauline L. , Lindsey Bruce D. , Wood Warren T. , Kirchheim Roberto E. , Cherry John A. 
Published: May 2022

AbstractInformed analysis of policies related to food security, global climate change, wetland ecology, environmental nutrient flux, element cycling, groundwater weathering, continental denudation, human health, and others depends to a large extent on quantitative estimates of solute mass fluxes into and out of all global element pools including the enigmatic global aquifer systems. Herein for the first time, we proffer the mean global solute concentration of all major and selected minor and trace solutes in the active groundwater that represents 99% of liquid fresh water on Earth. Concentrations in this significant element pool have yielded to a geospatial machine learning kNN‐nearest neighbors' algorithm with numerous geospatial predictors utilizing a large new lithology/climate/aquifer age/elevation based solute database. The predicted concentrations are consistent with traditional solute ratios, concentrations, and thermodynamic saturation indices.
European principles of care for physiotherapy provision for persons with inherited bleeding disorders: Perspectives of physiotherapists and patients
Authors: de Kleijn Piet , Duport G. , Jansone K. , Marinić M. , McLaughlin P. , Noone D. , Ramishvili L. , Tollwé A. , Stephensen D. ,   the European Haemophilia Consortium and EAHAD Physiotherapy Committee
Published: May 2022

AbstractIntroductionIn their Chronic Care Model, the World Health Organisation states that people with chronic disorders and their families should be informed about the expected course, potential complications, and effective strategies to prevent complications and manage symptoms. Physiotherapists are a key professional group involved in the triage, assessment and management of musculoskeletal conditions of persons with a bleeding disorder (PWBD). Nevertheless, recent reports describe access to physiotherapy for those with these conditions is only sometimes available.AimAccess to high quality individualised physiotherapy should be ensured for all PWBD, including those with mild and moderate severities, male and female, people with von Willebrand Disease (vWD) and other rare bleeding disorders. Physiotherapy should be viewed as a basic requisite in their multidisciplinary care.Methods/ resultsFollowing a series of meetings with physiotherapists representing the European Association for Haemophilia and Allied Disorders (EAHAD) and PWBD representing the European Haemophilia Consortium (EHC) and a review of publications in the field, eight core principles of physiotherapy care for persons with a bleeding disorder have been co‐produced by EAHAD and EHC.ConclusionThese eight principles outline optimum standards of practice in order to advocate personalised patient‐centred care for physical health in which both prevention and interventions include shared decision making, and supported self‐management.
Aberrant IKZF1 gene as relapse predictor in standard‐risk pediatric patients with B‐cell precursor acute lymphoblastic leukaemia
Authors: Vshyukova Volha Sergeevna , Krasko Olga Vladimirovna , Yanchanka Darya Alexandrovna , Meleshko Alexander Nikolayevich 
Published: May 2022

AbstractIntroductionWorldwide, the B‐cell precursor acute lymphoblastic leukaemia (BCP‐ALL) treatment protocols are based on risk‐adaptive therapy, that is on the search for biological markers for stratification by risk groups for optimal management. Depending on the treatment protocol, deletions and overexpression of non‐functional IKZF1 isoforms act as relapse predictors in ALL. We investigated the IKZF1 gene aberrations as the substantive marker for predicting the development of relapse or adverse events when using risk stratification from ALL‐MB‐2002/2008 protocols.MethodsWe retrospectively analysed the bone marrow samples collected from 202 newly diagnosed patients with BCP‐ALL harbouring IKZF1 aberrations.ResultsIn patients of intermediate‐ and high‐risk the presence of IKZF1 aberrations contributed to the delayed clearance of blast cells on the 15th and 36th day of induction therapy, but there was not a significant effect on relapse rate. The comparative analysis demonstrated that standard‐risk patients with IKZF1 aberrations have a much higher 5‐years cumulative incidence of relapse (66.7 ± 22.7% vs. 11.6 ± 2.9% in the group with normal gene status, p < 0.001) in contrast to intermediate‐ and high‐risk groups. In the competing risk model of relapse, IKZF1 aberrations determine a high risk of relapse only in standard‐risk patients (p = 0.025), and it was not significant for patients of other risk groups (p = 0.284 for intermediate, and 0.408 for high‐risk groups).ConclusionOur findings support that IKZF1 aberrations are a crucial relapse predictor in standard‐risk patients with BCP‐ALL, who practically have no significant markers to assess the prognosis during the primary diagnosis.
How the COVID‐19 lockdown affects social relationships in Bangladesh: A social media‐based cross‐sectional study
Authors: Dey Sima Rani 
Published: May 2022

AbstractFor controlling the rapid spread of COVID‐19 infections, the Bangladesh Government imposed lockdown to ensure social distancing among the mass. The study aimed to investigate the effect of COVID‐19 lockdown on social relationships among Bangladeshi nationals. A social media‐based cross‐sectional study was conducted from May 15 through June 7, 2020. The study used a survey questionnaire to ascertain the people's perception on COVID‐19 pandemic and its associated lockdown, and on how the lockdown affected their social relationships. In this study, social relationships referred to the connections between family members, friends, and relatives. Linear regression was employed to determine the predictors of social relationships. A total of 352 survey responses were collected, out of which 64.2 per cent reported that their social relationships became stronger during lockdown. Age, marital status, occupation, and financial condition exhibited significant associations with social relationships. More specifically, young through middle‐aged, married, housewives, and financially solvent people had a significant association with having strong social relationships. This study found that the COVID‐19 lockdown revealed a positive impact on the social relationships of Bangladeshis. Healthy bonding and cordial support of family and friends are understood to have helped them to mitigate their mental stress, leading to positive health implications.
NANDA International nursing diagnoses in the coping/stress tolerance domain and their linkages to Nursing Outcomes Classification outcomes and Nursing Interventions Classification interventions in the pre‐hospital emergency care
Authors: Sánchez‐Almagro César Pedro , Romero‐Sánchez José Manuel , White‐Ríos Melanie , González del Pino Carlos Antonio , Paloma‐Castro Olga 
Published: May 2022

AbstractAimTo determine the prevalence of NANDA International nursing diagnoses in the coping/stress tolerance domain and their linkages to Nursing Outcomes Classification outcomes and Nursing Interventions Classification interventions in the pre‐hospital emergency care setting.DesignRetrospective descriptive study of electronic record review.MethodsEight thousand three hundred three episodes recorded during the year 2019 were recovered from the electronic health records of a public emergency care agency. The prevalence of NANDA International nursing diagnosis, Nursing Outcomes Classification outcomes and Nursing Interventions Classification interventions was determined. A cross‐tabulation analysis was performed to determine the linkages. Data were accessed in November 2020.ResultsNANDA International nursing diagnoses Anxiety (00146) and Fear (00148) represented more than 90% of the diagnoses recorded in the domain. Anxiety level (1211) and emotional support (5270) were the most recorded Nursing Outcomes Classification outcomes and Nursing Interventions Classification interventions, with almost 20% and 5% of total records, respectively. The linkage between nursing diagnosis Anxiety (00146), outcome Anxiety level (1211) and intervention Anxiety reduction (5820) was the most recorded with slightly more than 3% of the total.ConclusionEight different NANDA International nursing diagnoses in the coping/stress tolerance domain were recorded. Nursing Outcomes Classification outcomes were selected aimed mainly at psychological well‐being and Nursing Interventions Classification interventions to support coping. In general, linkages were aimed to provide emotional support, physical well‐being, information, education and safety.ImpactThis study showed that pre‐hospital emergency care nurses diagnose and treat human responses in the coping/stress tolerance domain. Expert consensus‐based linkages may be complemented by the results of this study, increasing the levels of evidence of both individualized and standardized care plans for critical patients assisted by pre‐hospital emergency care nurses.
Sorting out the sorting in omnichannel retailing
Authors: Kembro Joakim , Eriksson Ebba , Norrman Andreas 
Published: May 2022

AbstractThe increasing complexity of today's omnichannels has led to challenges with logistics efficiency and customer utility. In this paper, we show how retailers address these challenges by sorting goods at multiple points across the logistics network and inside each material‐handling node. As contemporary research on the omnichannel sorting phenomenon is limited and fragmented, we conduct an abductive multiple case study to elaborate omnichannel logistics and transvection theory. It explains why retailers, depending on their omnichannel context, prepone some sorting activities upstream and postpone others to handle trade‐offs between customer utility and logistics efficiency. An artifact, including structured terminology, six sorting aspects, and an iconographic platform, is constructed to support the analysis of the extent, variety, and complexity of sorting at both the strategic network level and the operational material‐handling node level. We conclude by submitting 10 theoretical and actionable design propositions that support decision making in (re)designing omnichannel logistics networks and offer avenues for future research.
Cognitive biases as impediments to enhancing supply chain entrepreneurial embeddedness
Authors: Ketchen David J. , Craighead Christopher W. 
Published: May 2022

AbstractThe recently introduced concept of supply chain entrepreneurial embeddedness (SCEE) refers to the extent to which large firms integrate entrepreneurial capabilities into their supply chains. Achieving a higher degree of SCEE can involve assimilating entrepreneurial practices by copying entrepreneurial firms’ behavior, allying with entrepreneurial firms to gain access to and learn from them, and acquiring entrepreneurial firms to bring their practices inside the firm. Because SCEE appears to be a pathway to enhanced firm performance, enhancing SCEE should be attractive. However, our thesis is that efforts to do so may be undermined by cognitive biases—heuristics used by the human mind to simplify complex situations that result in distorted thinking. We explore the possible problems arising due to 11 cognitive biases discussed by Schwenk (Strategic Management Journal, 1984, 5(2), 111). We offer two brief case examples of companies that are seeking to make their supply chains more entrepreneurial; each illustrates several of the biases in action. We also consider whether supply chain complexity and entrepreneurial orientation can mitigate or strengthen cognitive biases’ harmful effects on SCEE. In doing so, we construct an important interface across entrepreneurship and supply chain management.
Editorial Perspective: Rapid responses to understand and address children and young people’s mental health in the context of COVID‐19
Authors: Creswell Cathy 
Published: May 2022

Prior to the pandemic, we already had good reason to be concerned about the mental health of children and young people. As an example, the 2017 Mental Health of Children and Young People (MHCYP) survey in England, comprising a large, national probability sample, identified that one in nine children had a probable mental health disorder, with a 49% increase in emotional disorders compared to a previous survey in 2004 (Sadler et al., 2018). The pandemic has clearly brought a broad range of challenges to children and young people. These include the direct viral threat to self, friends, and family (with recent estimates of a 17.5%–20.2% increase in parental bereavement in the United States; Kidman et al, 2021), as well as disruptions to school work, social interactions, family pressures, economic impacts, a lack of opportunity and ongoing uncertainty, and reduced access to mental health and other support from outside the home. So how have these experiences affected the mental health of children and young people?
Negotiating mutualism: A locus for exploitation by rhizobia has a broad effect size distribution and context‐dependent effects on legume hosts
Authors: Wendlandt Camille E. , Roberts Miles , Nguyen Kyle T. , Graham Marion L. , Lopez Zoie , Helliwell Emily E. , Friesen Maren L. , Griffitts Joel S. , Price Paul , Porter Stephanie S. 
Published: May 2022

AbstractIn mutualisms, variation at genes determining partner fitness provides the raw material upon which coevolutionary selection acts, setting the dynamics and pace of coevolution. However, we know little about variation in the effects of genes that underlie symbiotic fitness in natural mutualist populations. In some species of legumes that form root nodule symbioses with nitrogen‐fixing rhizobial bacteria, hosts secrete nodule‐specific cysteine‐rich (NCR) peptides that cause rhizobia to differentiate in the nodule environment. However, rhizobia can cleave NCR peptides through the expression of genes like the plasmid‐borne Host range restriction peptidase (hrrP), whose product degrades specific NCR peptides. Although hrrP activity can confer host exploitation by depressing host fitness and enhancing symbiont fitness, the effects of hrrP on symbiosis phenotypes depend strongly on the genotypes of the interacting partners. However, the effects of hrrP have yet to be characterised in a natural population context, so its contribution to variation in wild mutualist populations is unknown. To understand the distribution of effects of hrrP in wild rhizobia, we measured mutualism phenotypes conferred by hrrP in 12 wild Ensifer medicae strains. To evaluate context dependency of hrrP effects, we compared hrrP effects across two Medicago polymorpha host genotypes and across two experimental years for five E. medicae strains. We show for the first time in a natural population context that hrrP has a wide distribution of effect sizes for many mutualism traits, ranging from strongly positive to strongly negative. Furthermore, we show that hrrP effect size varies across host genotypes and experiment years, suggesting that researchers should be cautious about extrapolating the role of genes in natural populations from controlled laboratory studies of single genetic variants.
Responses to artificial selection for locomotor activity: A focus on death feigning in red flour beetle
Authors: Matsumura Kentarou , Sasaki Ken , Miyatake Takahisa 
Published: May 2022

AbstractWhole‐organism performance, including locomotor activity, is an important fitness trait in many animals. Locomotor activity is often classified into sprint speed and locomotor endurance and differences in sprint speed and locomotor endurance affect on other traits such as life‐history traits. Previous studies found that locomotor endurance, sprint speed and brain dopamine (DA) levels are correlated with artificial selection for death feigning (an anti‐predator behaviour that we refer to as ‘death‐feigning syndrome’) in some insect species. Thus, if the syndrome has a genetic basis, death feigning, sprint speed and brain DA levels may be affected by artificial selection for locomotor endurance. We artificially selected for locomotor endurance over 10 generations in the red flour beetle Tribolium castaneum, and established higher (H) and lower activity (L) strains, then compared their death‐feigning behaviour, sprint speed and brain DA levels. H‐strain beetles exhibited significantly shorter duration of death‐feigning, and significantly higher sprint speeds, suggesting variation in death‐feigning syndrome. Surprisingly, although brain DA expression affects various animal behaviours, we found no significant differences in the brain DA expressions of H‐ and L‐strain beetles. Thus, our results imply genetic correlations between locomotor endurance, sprint speed and death feigning, but not with brain DA expression, suggesting that differences in the biogenic amine results of our and previous studies may reflect differences in behavioural expression mechanisms.
Higher red cell distribution width and poorer hospitalization‐related outcomes in elderly patients
Authors: Kim Kyoung Min , Nerlekar Ridhima , Tranah Gregory J. , Browner Warren S. , Cummings Steven R. 
Published: May 2022

AbstractBackgroundRed cell distribution width (RDW), an index for variation of red blood cell (RBC) size, has been proposed as a potential marker for poorer outcomes in several aging‐related diseases and conditions. We tested whether greater variability of RBC size, presented as a higher RDW value, predicts poor prognoses among hospitalized patients over 60 years old.MethodsWe retrospectively collected data from older hospitalized patients aged ≥60 years between January 2013 to December 2017 at Sutter Health, a large integrated health system in Northern California. The RDW was measured during hospital admission and categorized with 1% intervals (≤13.9, 14.0–14.9, 15.0–15.9, 16.0–16.9, 17.0–17.9 and ≥18.0%). The primary outcome was the rate of in‐hospital mortality and secondary outcomes included 30‐day re‐admission rate and length of hospital stay (in days).ResultsA total of 167,292 admissions from 94,617 patients were included. The overall in‐hospital mortality rate was 6.3%. As the RDW value increased, the rate of in‐hospital mortality gradually increased from 2.7% for the lowest RDW category to 12.2% in the highest category (p‐trend <0.001). The overall 30‐day re‐admission rate after discharge was 12.5% and the rate of 30‐day re‐admission also increased with increasing RDW categories (7.4% in the lowest group vs. 15.8% in the highest group, p‐trend <0.001). Patients with the highest RDW values at admission stayed 1.5–2.0 times longer in the hospital than patients with lower RDW values who were admitted for the same causes.ConclusionsGreater variability of RBC size is significantly associated with worse prognosis in hospitalized elderly patients, indicating higher mortality, greater risk of early re‐admission, and longer hospital stay days. Risk stratification strategies for hospitalized elderly should include RDW value.