bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the therapeutic effect of mesoporous silica nanoparticles loaded with Gallic acid on reserpine-induced depression in Wistar rats
Authors: Fahmy Heba M. , Mohamed Eman R. , Hussein Aida A. , Khadrawy Yasser A. , Ahmed Nawal A. 
Published: June 2022

Abstract
Background
The current study evaluates the free gallic acid (GA) and GA-loaded mesoporous silica nanoparticles (MSNs) antidepressant efficacy in a rat model of depression caused by reserpine.

Methods
By using a scanning electron microscope (SEM), dynamic light scattering (DLS), and zeta potential, MSNs and GA-loaded MSNs were characterized. The efficiency of encapsulation and the release of GA-loaded MSNs were also investigated. The effect of GA, either in its free form or loaded on (MSNs) on oxidative stress biomarkers and monoamine neurotransmitters levels (serotonin (5-HT), norepinephrine (NEP), and dopamine (DA)), were evaluated in these areas (cortex, hippocampus, striatum, and hypothalamus) of control, a depression model of rat, a depression model of rat treated with either free GA, MSNs or GA loaded MSNs. The forced swimming test (FST) also the open field test (OFT) were carried out to evaluate the behavioral changes in all groups.

Results
Reserpine caused a decrease in the time spent in motor and swimming activity besides increasing the time of immobility, as demonstrated by OFT and FST. Significantly reductions in 5-HT, NEP, and DA were obtained in the cortex, hippocampus, hypothalamus, and striatum of reserpine-treated rats. Free GA was more effective in increasing the serotonin level in the cortex, hippocampus, and hypothalamus, while GA-loaded MSNs were more effective in increasing it in the striatum. GA-loaded MSNs also increased the level of NEP in the four studied brain areas. Free GA increased dopamine levels in the cortex and striatum, whereas GA-loaded MSNs increased DA levels in the hippocampus and hypothalamus compared with the depressed untreated group.

Conclusions
MSNs can be used as a drug delivery system to target GA selectively to specific brain areas.
Major to trace element imaging and analysis of iron age glasses using stage scanning in the analytical dual beam microscope (tandem)
Authors: Vicenzi Edward P. , Lam Thomas , Weaver Jamie L. , Herzing Andrew A. , McCloy John S. , Sjöblom Rolf , Pearce Carolyn I. 
Published: June 2022

Abstract
Dark and clear silicate glasses formed during an iron age vitrification event ≈ 1500 years ago at the Broborg hillfort near Uppsala, Sweden have been analyzed using a scanning electron microscope equipped with a micro-X-ray fluorescence (μXRF) spectrometer. Correlated µXRF and electron beam-induced energy dispersive spectrometry (EDS) X-ray maps were collected via stage-scanning at constant velocity. This coupled procedure represents a new approach for the cultural heritage community to conduct analytical studies of archaeometric specimens composed of metal, ceramic, or mixed inorganic/organic materials, where major and trace element compositions are registered in space for areas up to the centimeter-length scale at micrometer-scale resolution. Overview images were used to select areas for EDS beam scan maps correlated with multispectral cathodoluminescence (CL) imaging and co-located quantitative EDS and μXRF point analysis. Fe, Ca, Mg, Ti, P, Mn, Zr, Zn, and Y are enriched in the dark glass, while Si, Al, K, Na, Ba, Sr, Rb, and Ga are enriched in the clear glass. Unmelted material is comprised predominately of quartz (SiO2) along with trace apatite (Ca5(PO4)3[Cl,OH]) and zircon (ZrSiO4). Multivariate statistical analysis was used to measure the area fractions of high variance components while lower variance components represented phase mixtures. Differences between calculated melt viscosities for the glass compositions are consistent with field and laboratory observations. Coupled large area EDS and μXRF imaging shows significant promise for informed selection of higher spatial resolution and higher sensitivity follow-up studies, e.g., those performed using synchrotron analysis.

Graphical Abstract
2D and 3D representation of objects in architectural and heritage studies: in search of gaze pattern similarities
Authors: Rusnak Marta 
Published: June 2022

Abstract
The idea of combining an eye tracker and VR goggles has opened up new research perspectives as far as studying cultural heritage is concerned, but has also made it necessary to reinvestigate the validity of more basic eye-tracking research done using flat stimuli. Our intention was to investigate the extent to which the flattening of stimuli in the 2D experiment affects the obtained results. Therefore an experiment was conducted using an eye tracker connected to virtual reality glasses and 3D stimuli, which were a spherical extension of the 2D stimuli used in the 2018 research done using a stationary eye tracker accompanied by a computer screen. The subject of the research was the so-called tunnel church effect, which stems from the belief that medieval builders deliberately lengthened the naves of their cathedrals to enhance the role of the altar. The study compares eye tracking data obtained from viewing three 3D and three 2D models of the same interior with changed proportions: the number of observers, the number of fixations and their average duration, time of looking at individual zones. Although the participants were allowed to look around freely in the VR, most of them still performed about 70–75% fixation in the area that was presented in the flat stimuli in the previous study. We deemed it particularly important to compare the perception of the areas that had been presented in 2D and that had evoked very much or very little interest: the presbytery, vaults, and floors. The results indicate that, although using VR allows for a more realistic and credible research situation, architects, art historians, archaeologists and conservators can, under certain conditions, continue to apply under-screen eye trackers in their research. The paper points out the consequences of simplifying the research scenario, e.g. a significant change in fixation duration. The analysis of the results shows that the data obtained by means of VR are more regular and homogeneous.

Graphical Abstract
Urinary Incontinence Among Elite Track and Field Athletes According to Their Event Specialization: A Cross-Sectional Study
Authors: Rodríguez-López Elena Sonsoles , Acevedo-Gómez María Barbaño , Romero-Franco Natalia , Basas-García Ángel , Ramírez-Parenteau Christophe , Calvo-Moreno Sofía Olivia , Fernández-Domínguez Juan Carlos 
Published: June 2022

Abstract
Background
Physical effort in sports practice is an important trigger for urinary incontinence (UI). Among high-impact sports, all track and field events require continuous ground impacts and/or abdominal contractions that increase intra-abdominal pressure and impact on the pelvic floor musculature. However, studies to date have not taken into account the specific sports tasks that elite track and field athletes perform according to the competitive events for which they are training.

Methods
This cross-sectional study describes the prevalence, type, and severity of UI among elite track and field athletes considering their event specialization and training characteristics. A total of 211 female and 128 male elite track and field athletes answered an online questionnaire including anthropometric measures, medical history, training characteristics, and UI symptoms. To determine self-reported UI, the International Consultation on Incontinence Questionnaire-UI Short-Form (ICIQ-UI-SF) was used. To determine UI type and severity, the incontinence questionnaire and incontinence severity index were used, respectively.

Results
The ICIQ-UI-SF showed that 51.7% of female and 18.8% of male athletes had UI, with stress UI (SUI) being the most frequent type (64.4%) for female and urge UI for male athletes (52.9%). Of athletes who were not identified as having UI according to the questionnaires, 24.6% of female and 13.6% of male athletes experienced urine leakage during training, mainly during jumping. Although training characteristics (experience, volume, and resting) were not related to UI, female athletes specializing in vertical jumps showed significantly lower UI prevalence compared to those specializing in horizontal jumps (χ2 [1] = 4.409, p = 0.040), middle-distance running (χ2 [1] = 4.523, p = 0.033), and sprint/hurdles events (χ2 [1] = 4.113, p = 0.043). These female athletes also displayed the lowest training volume. No differences were shown for males (p > 0.05).

Conclusions
Over half of the elite track and field female athletes have self-reported UI, especially SUI, and prevalence is higher when considering urine leakage events during training. Training characteristics and specialization were not related to UI identified by questionnaires, but female athletes specializing in vertical jump events showed the lowest prevalence and training volume. Males showed significantly lower prevalence, without correlation with their specialization. Sport professionals should increase UI detection among elite athletes and design-specific approaches that consider their physical demands to make visible, prevent, or improve pelvic floor dysfunction in this population.
A clinical algorithm to determine target blood pressure in the elderly: evidence and limitations from a clinical perspective
Authors: Shin Jinho , Kim Kwang-il 
Published: June 2022

AbstractAs the elderly population is growing rapidly, management of hypertension in South Korea faces major challenges because the proportion of elderly hypertension patients is also increasing. The characteristics of this population are also much more complex than younger patients. Elderly hypertension is characterized by wide variations in (1) fitness or biological age, (2) white-coat effect, (3) poor functional status or frailty, (4) dependency in activities of daily living or institutionalization, (5) orthostatic hypotension, and (6) multiple comorbidities. All of these should be considered when choosing optimal target blood pressure in individual patients. Recent randomized clinical trials have shown that the benefits of intensive blood pressure control for elderly patients is greater than previously thought. For generalization of these results and implementation of the guidelines based on these studies, defining the clinician’s role for individualization is critically important. For individualized decisions for target blood pressure (BP) in the elderly with hypertension, four components should first be checked. These consist of (1) the minimum requirement of functional status and capability of activities of daily living, (2) lack of harmful evidence by the target BP, (3) absence of white-coat hypertension, and (4) standing systolic BP ≥ 110 mmHg without orthostatic symptoms. Risk of decreased organ perfusion by arterial stenosis should be screened before starting intensive BP control. When the target BP differs among comorbidities, the lowest target BP should be given preference. After starting intensive BP lowering therapy, tolerability should be monitored, and the titration should be based on the mean level of blood pressure by office supplemented by out-of-office BPs. Applications of the clinical algorithms will be useful to achieve more standardized and simplified applications of target BP in the elderly.
Grandparents, family solidarity and the division of housework: evidence from the Italian case
Authors: Albertini Marco , Tosi Marco 
Published: June 2022

AbstractAs a consequence of recent socio-demographic trends and labour market transformations the role of grandparental support has become pivotal in individuals’ and households’ life courses. In Southern European countries the availability of grandparents affects young couples’ labour market participation and fertility decisions. In the present paper, it is asked if the potential availability of social support from the older family generation is associated with more or less inequality in the division of unpaid housework in couples with minor children, in Italy. Using data from the 2016 Family and Social Subjects survey it is shown that while there is not a clear relation between intergenerational face-to-face contacts and the symmetry of the division of household labour, adult children and older (grand)parents coresidence is associated with a more gender-equal sharing of housework within couples, arguably because co-residing grandparents take on the execution of a number of household tasks. The observed effect is comparable to that of hiring a paid housekeeper and higher than hiring a babysitter. Thus, despite one may think that three-generation households are characterized by a culture of traditional norms, our findings indicate that they have a more gender-equal division of housework.
Bayesian latent class analysis produced diagnostic accuracy estimates that were more interpretable than composite reference standards for extrapulmonary tuberculosis tests
Authors: MacLean Emily L. , Kohli Mikashmi , Köppel Lisa , Schiller Ian , Sharma Surendra K. , Pai Madhukar , Denkinger Claudia M. , Dendukuri Nandini 
Published: June 2022

AbstractBackgroundEvaluating the accuracy of extrapulmonary tuberculosis (TB) tests is challenging due to lack of a gold standard. Latent class analysis (LCA), a statistical modeling approach, can adjust for reference tests’ imperfect accuracies to produce less biased test accuracy estimates than those produced by commonly used methods like composite reference standards (CRSs). Our objective is to illustrate how Bayesian LCA can address the problem of an unavailable gold standard and demonstrate how it compares to using CRSs for extrapulmonary TB tests.MethodsWe re-analyzed a dataset of presumptive extrapulmonary TB cases in New Delhi, India, for three forms of extrapulmonary TB. Results were available for culture, smear microscopy, Xpert MTB/RIF, and a non-microbiological test, cytopathology/histopathology, or adenosine deaminase (ADA). A diagram was used to define assumed relationships between observed tests and underlying latent variables in the Bayesian LCA with input from an inter-disciplinary team. We compared the results to estimates obtained from a sequence of CRSs defined by increasing numbers of positive reference tests necessary for positive disease status.ResultsData were available from 298, 388, and 230 individuals with presumptive TB lymphadenitis, meningitis, and pleuritis, respectively. Using Bayesian LCA, estimates were obtained for accuracy of all tests and for extrapulmonary TB prevalence. Xpert sensitivity neared that of culture for TB lymphadenitis and meningitis but was lower for TB pleuritis, and specificities of all microbiological tests approached 100%. Non-microbiological tests’ sensitivities were high, but specificities were only moderate, preventing disease rule-in. CRSs’ only provided estimates of Xpert and these varied widely per CRS definition. Accuracy of the CRSs also varied by definition, and no CRS was 100% accurate.ConclusionUnlike CRSs, Bayesian LCA takes into account known information about test performance resulting in accuracy estimates that are easier to interpret. LCA should receive greater consideration for evaluating extrapulmonary TB diagnostic tests.
The effect of hypocalcemia on motor symptoms of Parkinson’s disease
Authors: Emad Engy M. , Elmotaym Amal S. E. , Ghonemy Mo’men A. , Badawy Ahmed E. 
Published: June 2022

Abstract
Background
The disabling nature of Parkinson’s disease (PD) impairs functional mobility and worsens quality of life. Calcium imbalances are thought to have a significant role in the progression of PD.

Objective
To evaluate the relation between calcium deficiency and deterioration of PD motor symptoms.

Methods
A total of 28 idiopathic PD patients were subjected to motor symptoms evaluation using the modified Hoehn–Yahr scale (H–Y), Unified Parkinson’s Disease Rating Scale (UPDRS) Part II and III and Schwab and England Activities of Daily Living Scale (S–E ADL). Total and ionized serum calcium levels were measured for the PD patients and the 30 healthy control subjects.

Results
The level of ionized calcium was significantly lower among PD patients (4.19 mg/dl ± 0.53) than in control subjects (4.8 mg/dl ± 0.35) (p < 0.0001). The PD patients with hypocalcemia showed marked deterioration of motor symptoms and significant impairment of daily life activities when compared to PD patients with normal calcium levels regarding their scores on the modified H–Y scale (p = 0.001), UPDRS-III (p = 0.001), UPDRS-II (p = 0.001), and S–E ADL scale (p = 0.001). Ionized calcium correlated significantly with PD patients’ scores on the modified H–Y scale (p = 0.019), UPDRS-Part II (p = 0.001), UPDRS-Part III (p = 0.001) and S–E ADL scale (p = 0.001). The significant cutoff point of the ionized calcium for detection of the deteriorated PD patients that presented with stages more than grade 2 of the modified H–Y scale was < 3.99 (p = 0.037) with a sensitivity of 80% and specificity of 95%.

Conclusions
Our findings conclude that calcium deficiency could contribute to the deterioration of PD motor symptoms.
Bruxism and implant: where are we? A systematic review
Authors: Youssef Abboud , Hobeiche Joe , El Zoghbi Amine , Mortada Rola , Salameh Ziad 
Published: June 2022

Abstract
Background
The aim of this Systematic review is to provide more accurate knowledge about the relation between bruxism, Dental implant and the implant-supported prosthesis.
Main body.

Material and methods
A systematic search in Medline (PubMed) and manual search in implant-related journals was performed in February 2021 with time range extending from 2010 to 2021, with no language restriction in order to identify all papers assessing the role of bruxism, as a risk factor for implants and/or implant supported prosthesis.

Results
16 papers were included in the review and split into 3 categories assessing implant complications (n = 10), those reporting prosthetic complications (n = 3) and those reporting both (n = 3). From a biological and mechanical complications point of view, bruxism was related with implant and prosthetic failures.

Conclusion
Bruxism is a risk factor for implants failure, and a risk factor for mechanical complications for implant supported prosthesis as well.
Natural leather based gamma-ray shielding materials enabled by the coordination of well-dispersed Bi3+/Ba2+ ions and RE2O3 coating
Authors: Shen Yue , Zhou Jibo , Han Zheng , Li Hao , Yan Linping , Liao Xuepin , Shi Bi 
Published: June 2022

AbstractGamma rays is widely used in modern science and technology, but it may cause health damage to practitioners. In the present study, natural composites based on leather and high-Z elements (atomic number ≥ 56) were fabricated and used as gamma rays shielding materials. These shielding materials were prepared by coating rare earth nanoparticles (Er2O3 or La2O3) onto the surface of natural leather, which was first impregnated with Bi3+ and Ba2+. Results show that the attenuation efficiency of the prepared Er1.31Bi5.46-NL (1.31 and 5.46 mmol cm−3 loaded elements) with thickness of 3.2 mm was 61.57% for incident rays at 121.78 keV (152Eu) and reached 96.4% in the incident of 59.5 keV (241Am), which is comparable to that of 0.25-mm lead plate (54.54 mmol cm−3). In addition, these natural-leather-based shielding materials exhibited low density (approximately 1/10 of Pb), high strength and wearable behaviors.
Graphical abstract
HIV/AIDS patients undergoing total knee arthroplasty are at higher risk of acute renal failure and transfusion and incurred higher cost: a propensity-matched database study
Authors: Sakthivelnathan Vishaal , Senthil Tejas , Varatharaj Sushrruti , Mounasamy Varatharaj , Sambandam Senthil 
Published: June 2022

Abstract
Introduction
Human immunodeficiency virus (HIV) is a retrovirus that can cause acquired immunodeficiency syndrome (AIDS). Total knee arthroplasty (TKA) in HIV-positive patients has not been well documented in the current literature. Thus, this study aimed to examine the early postoperative outcomes and complications of HIV-positive TKA patients as compared to TKA patients who are HIV-negative patients by utilizing the National Inpatient Sample (NIS) database.

Methods
Admissions data for TKA and HIV were analyzed from the NIS database using ICD-10-CM diagnosis codes. An extensive array of preoperative and postoperative variables was compared among HIV positive TKA patients and HIV negative TKA patients. An unmatched analysis and a matched analysis using a 1:1 propensity match algorithm were conducted to compare the two groups.

Results
The average age of the HIV-positive group was lower than the HIV-negative group (59.0 vs 66.7, p < 0.001). The HIV-positive group had a smaller percentage of females (38.4% vs 61.5%, p < 0.001) and a lower incidence of tobacco-related disorders than the HIV-negative group (10.3% vs 15.8%, p = 0.032). The HIV-positive group had a longer mean length of stay (3.0 days vs 2.4 days, p < 0.001) and a greater mean total charge incurred (90,780.25 vs 64,801.55, p < 0.001). In the unmatched analysis, the incidence of acute renal failure (6.4% vs 2%, p < 0.001), transfusions (3.9% vs 1.5%, p = 0.004), and periprosthetic joint infection (3% vs 1%, p = 0.007) was higher in HIV positive group. The matched analysis showed a higher incidence of acute renal failure group (6.4% vs 0.5%, p = 0.01) and transfusions (3.9% vs 5%, p = 0.01) in the HIV-positive but a statistically insignificant difference in the rate of periprosthetic joint infection (3% vs 1%, p = 0.153).

Conclusion
HIV/AIDS is associated with an increased incidence of acute renal failure and transfusions, as well as a longer length of stay and higher incurred costs in TKA patients.
N-acetyl cysteine as a potential regulator of SARS-CoV-2-induced male reproductive disruptions
Authors: Sengupta Pallav , Dutta Sulagna 
Published: June 2022

Abstract
Background
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing the coronavirus disease 2019 (COVID-19), has shown its persistent pandemic strength. This viral infectivity, kinetics, and the mechanisms of its actions in human body are still not completely understood. In addition, the infectivity and COVID-19 severity reportedly differ with patient’s gender with men being more susceptible to the disease. Thus, different studies have also suggested the adverse impact of COVID-19 on male reproductive functions, mainly emphasizing on high expressions of angiotensin-converting enzyme 2 (ACE2) in the testes that allows the viral entry into the cells.

Main body
The N-acetylcysteine (NAC), a potent therapeutic agent of COVID-19, may be effective in reducing the impairing impacts of this disease on male reproductive functions. NAC acts as mucolytic agent by reducing sulfide bonds in the cross-linked glycoprotein matrix in mucus owing to its free sulfhydryl group. Since NAC also breaks the viral disulfide bonds required for the host cell invasion, it may help to prevent direct SARS-CoV-2 invasion into the testicular cells as well. NAC also acts as a potent anti-inflammatory and antioxidant, directly scavenging reactive oxygen species (ROS) and regulating the redox state by maintaining the thiol pool being a precursor of cysteine (an essential substrate for glutathione synthesis). Since it is suggested that male reproductive impairment in COVID-19 patient may be caused by secondary immune responses owing to systemic inflammation and OS, the anti-inflammatory and antioxidant properties of NAC explained above may attribute in protecting the male reproduction functions from these COVID-19-mediated damages.

Conclusion
This article explains the mechanisms how NAC treatment for COVID-19 may prevent the infection-mediated disruptions in male reproduction.