bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationships of Glucose, GLP-1, and Insulin Secretion With Gastric Emptying After a 75-g Glucose Load in Type 2 Diabetes
Authors: Jalleh Ryan J , Wu Tongzhi , Jones Karen L , Rayner Christopher K , Horowitz Michael , Marathe Chinmay S 
Published: May 2022

Abstract

Context
The relationships of gastric emptying (GE) with the glycemic response at 120 minutes, glucagon-like peptide-1 (GLP-1), and insulin secretion following a glucose load in type 2 diabetes (T2D) are uncertain.

Objective
We evaluated the relationship of plasma glucose, GLP-1, and insulin secretion with GE of a 75-g oral glucose load in T2D.

Design
Single-center, cross-sectional, post hoc analysis.

Setting
Institutional research center.

Participants
43 individuals with T2D age 65.6 ± 1.1 years, hemoglobin A1c 7.2 ± 1.0%, median duration of diabetes 5 years managed by diet and/or metformin.

Intervention
Participants consumed the glucose drink radiolabeled with 99mTc-phytate colloid following an overnight fast. GE (scintigraphy), plasma glucose, GLP-1, insulin, and C-peptide were measured between 0 and 180 minutes.

Main Outcome Measures
The relationships of the plasma glucose at 120 minutes, plasma GLP-1, and insulin secretion (calculated by Δinsulin0-30/ Δglucose0-30 and ΔC-peptide0-30/Δglucose0-30) with the rate of GE (scintigraphy) were evaluated.

Results
There were positive relationships of plasma glucose at 30 minutes (r = 0.56, P &lt; 0.001), 60 minutes (r = 0.57, P &lt; 0.001), and 120 minutes (r = 0.51, P &lt; 0.001) but not at 180 minutes (r = 0.13, P = 0.38), with GE. The 120-minute plasma glucose and GE correlated weakly in multiple regression models adjusting for age, GLP-1, and insulin secretion (P = 0.04 and P = 0.06, respectively). There was no relationship of plasma GLP-1 with GE. Multiple linear regression analysis indicated that there was no significant effect of GE on insulin secretion.

Conclusion
In T2D, while insulin secretion is the dominant determinant of the 120-minute plasma glucose, GE also correlates. Given the relevance to interpreting the results of an oral glucose tolerance test, this relationship should be evaluated further. There appears to be no direct effect of GE on either GLP-1 or insulin secretion.
Mitochondrial Homeostasis in Obesity-related Hypertriglyceridemia
Authors: Mela Virginia , Ruiz-Limón Patricia , Balongo Manuel , Motahari Rad Hanieh , Subiri-Verdugo Alba , Gonzalez-Jimenez Andres , Soler Rocio , Ocaña Luis , el Azzouzi Hamid , Tinahones Francisco J , Valdivielso Pedro , Murri Mora 
Published: May 2022

Abstract

Context
The prevalence of obesity and hypertriglyceridemia is an alarming worldwide health issue. Mitochondria play a central role in these disorders as they control cell metabolism.

Objective
The aim of the present study was to characterize mitochondrial homeostasis in subcutaneous and visceral adipose tissue (SAT and VAT) in grade III obese patients with and without hypertriglyceridemia. Moreover, this study presents the evaluation of mitochondrial fitness as a marker for hypertriglyceridemia improvement.

Patients
Eight control and 12 hypertriglyceridemic (HTG) grade III obese subjects undergoing bariatric surgery were included.

Main Outcome Measures
Anthropometric and biochemical data were obtained before and 3 months after surgery. Mitochondrial homeostasis was evaluated by mitochondrial DNA (mtDNA), gene expression and protein abundance in SAT and VAT.

Results
Mitophagy-related gene expression was increased in HTG SAT and VAT, while mitochondrial marker gene expression and mtDNA were decreased, indicating an altered mitochondrial homeostasis in HTG. Mitophagy protein abundance was increased in VAT of those subjects that did not improve their levels of triglycerides after bariatric surgery, whereas mitochondrial protein was decreased in the same tissue. Indeed, triglyceride levels positively correlated with mitophagy-related genes and negatively with mitochondrial content markers. Moreover, mitochondria content and mitophagy markers seem to be significant predictors of hypertriglyceridemia and hypertriglyceridemia remission.

Conclusions
Mitochondrial homeostasis of adipose tissue is altered in hypertriglyceridemic patients. At the protein level, mitochondria content and mitophagy are potential markers of hypertriglyceridemia remission in obese patients after bariatric surgery. These results may contribute to the implementation of a clinical approach for personalized medicine.
Hbxip is essential for murine embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1
Authors: Qin Yan , Ni Peiling , Zhang Qingye , Wang Xiao , Du Xiaoling , Yin Zixi , Wang Lingling , Ye Lihong , Chen Lingyi 
Published: May 2022

ABSTRACT
HBXIP, also named LAMTOR5, has been well characterized as a transcriptional co-activator in various cancers. However, the role of Hbxip in normal development remains unexplored. Here, we demonstrated that homozygous knockout of Hbxip leads to embryonic lethality, with retarded growth around E7.5, and that depletion of Hbxip compromises the self-renewal of embryonic stem cells (ESCs), with reduced expression of pluripotency genes, reduced cell proliferation and decreased colony-forming capacity. In addition, both Hbxip−/− ESCs and E7.5 embryos displayed defects in ectodermal and mesodermal differentiation. Mechanistically, Hbxip interacts with other components of the Ragulator complex, which is required for mTORC1 activation by amino acids. Importantly, ESCs depleted of Ragulator subunits, Lamtor3 or Lamtor4, displayed differentiation defects similar to those of Hbxip−/− ESCs. Moreover, Hbxip−/−, p14−/− and p18−/− mice, lacking subunits of the Ragulator complex, also shared similar phenotypes, embryonic lethality and retarded growth around E7-E8. Thus, we conclude that Hbxip plays a pivotal role in the development and differentiation of the epiblast, as well as the self-renewal and differentiation of ESCs, through activating mTORC1 signaling.
Chromosome organization through the cell cycle at a glance
Authors: Srinivasan Divyaa , Shisode Tarak , Shrinet Jatin , Fraser Peter 
Published: May 2022

ABSTRACT
Genome organization and the three-dimensional folding of chromosomes are now seen as major contributors to nearly all nuclear functions including gene regulation, replication and repair. Recent studies have shown that in addition to the dramatic metamorphoses in chromosome conformation associated with entry to, and exit from mitosis, chromosomes undergo continual conformational changes throughout interphase with differential dynamics in loop structure, topological domains, compartments and lamina-associated domains. Understanding and accounting for these cell-cycle-dependent conformational changes is essential for the interpretation of data from a growing array of powerful molecular techniques to investigate genome conformation function, and to identify the molecules and mechanisms that drive chromosome conformational changes. In this Cell Science at a Glance article and the accompanying poster, we review Hi-C and microscopy studies describing cell-cycle-dependent conformational changes in chromosome structure.
Laparoscopic Ovarian Transposition with Extraperitonealization of the Infundibulopelvic Ligament for Cervical Cancer in Ten Steps
Authors: Bizzarri Nicolò , Loverro Matteo , Angeles Martina A. , Pedone Anchora Luigi , Fagotti Anna , Fanfani Francesco , Ferrandina Gabriella , Scambia Giovanni , Querleu Denis 
Published: May 2022

AbstractPreservation of ovarian function is important for the physical and psychosexual well-being of young patients with cancer. Patients with pelvic malignancies such as cervical or rectal cancer planned for radiotherapy may benefit from ovarian transposition with the aim of moving the ovaries outside the radiation field.1 Different surgical techniques have been reported previously.2,3 With the present video, we aim to standardize the surgical technique of laparoscopic ovarian transposition in ten steps. We present the case of a 30-year-old nulliparous woman diagnosed with grade 3 squamous cell cervical carcinoma having a largest tumor diameter of 41 mm on magnetic resonance imaging (MRI) scan. The tumor was staged as FIGO 2018 stage IIIC1r with a common iliac lymphadenopathy reported on both MRI and positron emission tomography (PET)/computed tomography (CT) scan. The multidisciplinary team recommended exclusive chemoradiation extended to paraaortic area. The patient underwent laparoscopic bilateral salpingectomy and bilateral ovarian transposition with extraperitonealization of the infundibulopelvic ligament. The procedure was divided into the following ten steps: division of uteroovarian ligament, incision of lateral pelvic peritoneum, identification of ureter, incision of medial pelvic peritoneum, skeletonization of the infundibulopelvic ligament, retroperitoneal tunnel in paracolic gutter, creating the window (as high as possible), mobilization of the ovary without torsion, intraperitonealization of the ovary, and fix ovary with clips (Fig. 1). Surgical time was 30 min, with minimal estimated blood loss. No intra- or postoperative complication was recorded. The patient started radiotherapy 14 days after the procedure. In conclusion, we showed that laparoscopic ovarian transposition in cervical cancer before radiotherapy can be standardized in ten steps with encouraging perioperative results, making it an easily reproducible procedure. Ovarian function is reported to be preserved in 62–65% of cases undergoing ovarian transposition and radiation therapy.4,5
Assessing the role of vascular risk factors in dementia: Mendelian randomization meta-analysis and comparison with observational estimates
Authors: Lee Liam , Walker Rosie , Whiteley William 
Published: May 2022

Background: Although observational studies demonstrate that higher levels of vascular risk factors are associated with an increased risk of dementia, these associations might be explained by confounding or other biases. Mendelian randomization (MR) uses genetic instruments to test causal relationships in observational data. We sought to determine if genetically predicted modifiable risk factors (type 2 diabetes mellitus, low density lipoprotein cholesterol, high density lipoprotein cholesterol, total cholesterol, triglycerides, systolic blood pressure, diastolic blood pressure, body mass index, and circulating glucose) are associated with dementia by meta-analysing published MR studies. Secondary objectives were to identify heterogeneity in effect estimates across primary MR studies and to compare meta-analysis results with observational studies. Methods: MR studies were identified by systematic search of Web of Science, OVID and Scopus. We selected primary MR studies investigating the modifiable risk factors of interest. Only one study from each cohort per risk factor was included. A quality assessment tool was developed to primarily assess the three assumptions of MR for each MR study. Data were extracted on study characteristics, exposure and outcome, effect estimates per unit increase, and measures of variation. Effect estimates were pooled to generate an overall estimate, I2 and Cochrane Q values using fixed-effect model. Results: We screened 5211 studies and included 12 primary MR studies after applying inclusion and exclusion criteria. Higher genetically predicted body mass index was associated with a higher odds of dementia (OR 1.03 [1.01, 1.05] per 5 kg/m2 increase, one study, p=0.00285). Fewer hypothesized vascular risk factors were supported by estimates from MR studies than estimates from meta-analyses of observational studies. Conclusion: Genetically predicted body mass index was associated with an increase in risk of dementia.
TeenCovidLife: a resource to understand the impact of the COVID-19 pandemic on adolescents in Scotland
Authors: Huggins Charlotte F , Fawns-Ritchie Chloe , Altschul Drew M , Campbell Archie , Nangle Clifford , Dawson Rebecca , Edwards Rachel , Flaig Robin , Hartley Louise , Levein Christie , McCartney Daniel L , Sinclair Stephanie L , Dolan Clare , Haughton Dawn , Mabelis Judith , Brown Judith , Inchley Jo , Smith Daniel J , Deary Ian J , Hayward Caroline , Marioni Riccardo E , McIntosh Andrew M , Sudlow Cathie , Porteous David J 
Published: May 2022

TeenCovidLife is part of Generation Scotland’s CovidLife projects, a set of longitudinal observational studies designed to assess the psychosocial and health impacts of the COVID-19 pandemic. TeenCovidLife focused on how adolescents in Scotland were coping during the pandemic. As of September 2021, Generation Scotland had conducted three TeenCovidLife surveys. Participants from previous surveys were invited to participate in the next, meaning the age ranges shifted over time. TeenCovidLife Survey 1 consists of data from 5,543 young people age 12 to 17, collected from 22 May to 5 July 2020, during the first school closures period in Scotland. TeenCovidLife Survey 2 consists of data from 2,245 young people aged 12 to 18, collected from 18 August to 14 October 2020, when the initial lockdown measures were beginning to ease, and schools reopened in Scotland. TeenCovidLife Survey 3 consists of data from 597 young people age 12 to 19, collected from 12 May to 27 June 2021, a year after the first survey, after the schools returned following the second lockdown in 2021. A total of 316 participants took part in all three surveys. TeenCovidLife collected data on general health and well-being, as well as topics specific to COVID-19, such as adherence to COVID-19 health guidance, feelings about school closures, and the impact of exam cancellations. Limited work has examined the impact of the COVID-19 pandemic on young people. TeenCovidLife provides relevant and timely data to assess the impact of the pandemic on young people in Scotland. The dataset is available under authorised access from Generation Scotland; see the Generation Scotland website for more information.
Subset Selection with Shrinkage: Sparse Linear Modeling When the SNR Is Low
Authors: Mazumder Rahul , Radchenko Peter , Dedieu Antoine 
Published: May 2022

Learning Compact High-Dimensional Models in Noisy Environments Building compact, interpretable statistical models where the output depends upon a small number of input features is a well-known problem in modern analytics applications. A fundamental tool used in this context is the prominent best subset selection (BSS) procedure, which seeks to obtain the best linear fit to data subject to a constraint on the number of nonzero features. Whereas the BSS procedure works exceptionally well in some regimes, it performs pretty poorly in out-of-sample predictive performance when the underlying data are noisy, which is quite common in practice. In this paper, we explore this relatively less-understood overfitting behavior of BSS in low-signal noisy environments and propose alternatives that appear to mitigate such shortcomings. We study the theoretical statistical properties of our proposed regularized BSS procedure and show promising computational results on various data sets, using tools from integer programming and first-order methods.
Programmable bandstop filter based on spoof surface plasmon polaritons
Authors: Lu Minran , Xiao Lihua , Xiao Binggang , Yu Jiabin 
Published: May 2022

Spoof surface plasmon polaritons (SSPPs) have been developed rapidly because of the advantages of strong field constraints, low inter-channel cross talk, and low loss. However, the functions of plasmonic devices made of traditional passive SSPPs are completely fixed and cannot reach reconfigurable capability once the devices are fabricated. For the current development status, it is an urgent issue to design a reconfigurable device to control SPP waves dynamically in real time. This paper proposes a dynamic reconfigurable bandstop filter by using the concept of programmable SSPPs. The filter has a significant regulation function in the wideband range from 4 GHz to 22 GHz. The center frequency, number, and bandwidth of the stop band can be reconstructed in real time by programming the bias voltage, and the transmission coefficient (

S

21

) has good transmission performance of more than

−

3

d
B

. The results show that the experimental processing test is close to the theoretical simulation results, which proves the feasibility of the designed device. The study extends the functional principles of information science and digital logic to the application of physical devices.
Reconstructed quality improvement with a stochastic gradient descent optimization algorithm for a spherical hologram
Authors: Pan Yu , Wang Jun , Wu Yang , Peng Haohang , Yang Huan , Chen Chun 
Published: May 2022

The spherical holography is a promising technology to realize a true three-dimensional (3D) display. Compared to plane holography and cylindrical holography, it has an unlimited field of view, which can be observed from all perspectives. However, so far, the reconstructed images from computer-generated spherical holograms (CGSHs) are not of high quality, especially phase-only holograms, which will seriously affect its application. In this paper, an optimization algorithm for a CGSH based on stochastic gradient descent (SGD) is proposed to improve the quality of the reconstructed image. First, a new, to the best of our knowledge, diffraction model used in the process of optimization is proposed by considering the obliquity factor and occlusion culling. Based on our proposed diffraction model, the optimization process includes diffracting the initial random phase to another sphere, calculating the loss between the reconstructed image and the original image, and optimizing the initial phase through the SGD optimization algorithm. Both the correctness of the proposed diffraction model and the effectiveness of the SGD optimization for spherical holograms are verified well by numerical simulations. Through SGD, a high-quality reconstructed image can be achieved, which is 18 dB higher in the PSNR than that of spherical self-diffraction iteration. Meaningfully, our method has broad application prospects in 3D and omnidirectional displays. The SGD optimization algorithm is brought into the CGSH, and remarkable results have been achieved.
Ultrathin oxide controlled photocurrent generation through a metal–insulator–semiconductor heterojunction
Authors: Liu Ning , Yan Xiaohong , Gao Long , Beloshapkin Sergey , Silien Christophe , Wei Hong 
Published: May 2022

Recent advances in nanoscale lasers, amplifiers, and nonlinear optical converters have demonstrated the unprecedented potential of metal–insulator–semiconductor (MIS) structures as a versatile platform to realize integrated photonics at the nanoscale. While the electric field enhancement and confinement have been discussed intensively in MIS based plasmonic structures, little is known about the carrier redistribution across the heterojunction and photocurrent transport through the oxide. Herein, we investigate the photo-generated charge transport through a single CdSe microbelt-

Al

2

O
3

-Ag heterojunction with oxide thickness varying from 3 nm to 5 nm. Combining photocurrent measurements with finite element simulations on electron (hole) redistribution across the heterojunction, we are able to explain the loss compensation observed in hybrid plasmonic waveguides at substantially reduced pump intensity based on MIS geometry compared to its photonic counterpart. We also demonstrate that the MIS configuration offers a low-dark-current photodetection scheme, which can be further exploited for photodetection applications.
Biclustering reveals potential knee OA phenotypes in exploratory analyses: Data from the Osteoarthritis Initiative
Authors: Nelson Amanda E. , Keefe Thomas H. , Schwartz Todd A. , Callahan Leigh F. , Loeser Richard F. , Golightly Yvonne M. , Arbeeva Liubov , Marron J. S. 
Published: May 2022

Objective
To apply biclustering, a methodology originally developed for analysis of gene expression data, to simultaneously cluster observations and clinical features to explore candidate phenotypes of knee osteoarthritis (KOA) for the first time.

Methods
Data from the baseline Osteoarthritis Initiative (OAI) visit were cleaned, transformed, and standardized as indicated (leaving 6461 knees with 86 features). Biclustering produced submatrices of the overall data matrix, representing similar observations across a subset of variables. Statistical validation was determined using the novel SigClust procedure. After identifying biclusters, relationships with key outcome measures were assessed, including progression of radiographic KOA, total knee arthroplasty, loss of joint space width, and worsening Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, over 96 months of follow-up.

Results
The final analytic set included 6461 knees from 3330 individuals (mean age 61 years, mean body mass index 28 kg/m2, 57% women and 86% White). We identified 6 mutually exclusive biclusters characterized by different feature profiles at baseline, particularly related to symptoms and function. Biclusters represented overall better (#1), similar (#2, 3, 6), and poorer (#4, 5) prognosis compared to the overall cohort of knees, respectively. In general, knees in biclusters #4 and 5 had more structural progression (based on Kellgren-Lawrence grade, total knee arthroplasty, and loss of joint space width) but tended to have an improvement in WOMAC pain scores over time. In contrast, knees in bicluster #1 had less incident and progressive KOA, fewer total knee arthroplasties, less loss of joint space width, and stable pain scores compared with the overall cohort.

Significance
We identified six biclusters within the baseline OAI dataset which have varying relationships with key outcomes in KOA. Such biclusters represent potential phenotypes within the larger cohort and may suggest subgroups at greater or lesser risk of progression over time.
Postpartum during a pandemic: Challenges of low-income individuals with healthcare interactions during COVID-19
Authors: Gomez-Roas Maria V. , Davis Ka’Derricka M. , Leziak Karolina , Jackson Jenise , Williams Brittney R. , Feinglass Joe M. , Grobman William A. , Yee Lynn M. 
Published: May 2022

Background
Changes to the healthcare system due to COVID-19 have altered care delivery during birth and the postpartum period, a transitional time that requires intensive healthcare support and that is complicated by well-established health disparities. Our objective was to identify additional challenges to healthcare interactions that emerged for low-income postpartum individuals during the pandemic.

Methods
This is a qualitative investigation of low-income postpartum individuals enrolled in a trial of postpartum care, who gave birth in the United States in the first three months of the COVID-19 pandemic. Participants completed in-depth semi-structured interviews that addressed healthcare experiences during and after birth, both for in-person and telemedicine encounters. Transcripts were analyzed using the constant comparative method.

Results
Of 46 eligible individuals, 87% (N = 40) completed an interview, with 50% identifying as non-Hispanic Black and 38% as Hispanic. Challenges were organized into three domains: unanticipated changes in the birth experience, delayed care, and perceived disadvantages of telemedicine. Changes in the birth experience addressed uncertainty about COVID-19 status, COVID-19 testing, separation from newborn, and visitor restrictions. Delayed care themes addressed logistical challenges, postpartum care, health maintenance, and pediatric care. Participants reported multiple telemedicine-related challenges, including difficulty establishing rapport with providers.

Conclusions
Understanding the challenges experienced by low-income peripartum individuals as the COVID-19 pandemic evolves is critical to informing guidelines and diminishing inequities in healthcare delivery. Potential solutions that may mitigate limitations to care in the pandemic include emphasizing shared decision-making in care processes and developing communication strategies to improve telemedicine rapport.