bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sunspot Rotation Leading to Coronal Mass Ejection
Authors: Jiang Chaowei , feng xueshang , Bian Xinkai , Zou Peng , Duan Aiying , Yan Xiaoli , Hu Qiang , He Wen , Zuo Pingbing , Wang Yi 
Published: May 2022

Abstract
The rotation of sunspots around their umbral center has long been considered as an important process in driving coronal mass ejections (CMEs), but the specific mechanism remains unclear. Here with numerical magnetohydrodynamic simulations of both data-inspired and data-driven approaches, we show that the rotation of a large sunspot leads to a CME actually in a way distinct from the conventional view based on ideal instabilities of twisted flux rope. It is found that through the successive rotation of the sunspot the coronal magnetic field is sheared with a vertical current sheet created progressively, and once fast reconnection sets in the current sheet, the eruption is instantly triggered, with a highly twisted flux rope originating from the eruption. The simulations also revealed a slow-rise evolution phase sandwiched between the quasi-static energy-storage phase and the impulsive eruption-acceleration phase, and it enhances building up of the current sheet.
Comparison of predictive ability of macrocirculation and microcirculation markers on outcomes of patients with septic shock during initial fluid resuscitation: A prospective observational study
Authors: Shahsavarinia Kavous , Sabzevari Tara , Shadvar Kamran , Saghaleini Seied Hadi , Mahmoodpoor Ata , Ghamari Aliakbar , Vahedian-Azimi Amir , Samim Abbas , Rahimi-Bashar Farshid 
Published: May 2022

Abstract
This study was conducted to compare the predictive ability of the macrocirculation (mean arterial pressure, heart rate and central venous pressure), microcirculation markers (capillary refill time and peripheral perfusion index) and also fluid balance, lactate and clearance lactate on outcomes of patients with septic shock during initial resuscitation. This was a single-center observational study of 100 adult patients with septic shock who were admitted to the intensive care unit (ICU) at a university affiliated hospital in northwest of Iran. The area under the curve (AUC) of receiver operating characteristic (ROC) curve and multivariate logistic regression analyses were used. The AUCs for the macrocirculation and microcirculation markers for predicting mortality ranged from 0.517 to 0.770 and 0.695 to 0.993, respectively. Among the macrocirculation markers, the best predictive values for mortality were related to the central venous pressure and mean arterial pressure markers at baseline, with AUCs of 0.770 and 0.753, respectively. The microcirculation markers had a better predictive accuracy value for mortality in patients with septic shock than macrocirculation markers which the PPI is the best one. The combination of markers had a greater AUC with higher sensitivity and specificity than the marker alone to predict outcomes.
Comparison of FWHM and peak power of FBG spectrum for simultaneous measurement of strain and temperature based on tilted cantilever beam
Authors: mansoursamaei mohsen , Gholampour Mahdi , Malakzadeh Abdollah , Mansoursamaei Fatemeh 
Published: May 2022

Abstract
Among the optical fiber sensors, fiber Bragg grating (FBG) has found remarkable attraction and many applications due to its ability to measure all environmental parameters, high accuracy and sensitivity, easy installation, and low price. The sensor's ability to simultaneous measurement of two environmental (physical) parameters, especially strain and temperature, has made it even more demanding. Recently, two techniques based on FWHM and peak power changes of FBG spectrum have been proposed for simultaneous measurement of temperature and strain that use a uniform FBG on a tilted cantilever beam. In this article, we evaluate and compare both techniques and demonstrate that both are equivalent and have almost similar behaviour but do not have the same applications. We find that at the low strain range the peak power technique is more accurate while at the high strain range the FWHM technique has better accuracy. Therefore, in applications such as monitoring civil structures that have a high strain range, it is better to use the FWHM technique and in some delicate industrial applications with a low strain range, the peak power technique is used.
Analyses of adult transcriptomes from four different populations of the spongy moth, Lymantria dispar L., from China and the USA
Authors: Wang Yi-Ming , Sparks Michael E. , Harrison Robert L. , Shi Juan 
Published: May 2022

Abstract
The spongy moth Lymantria dispar, formerly known as the gypsy moth, is a forest pest that occurs as two different biotypes: the European spongy moth (ESM), Lymantria dispar dispar, which is distributed in Europe and North America; and the Asian spongy moth (ASM), which consists of subspecies Lymantria dispar asiatica and Lymantria dispar japonica and is distributed in China, Russia, Korea, and Japan. The Asian biotype is classified as a quarantine pest by the U.S. Department of Agriculture because of the superior flight ability of adult females compared to females of the European biotype. To identify genes that potentially account for differences in female flight capability between the two biotypes, we assembled and compared transcriptional profiles of two North American populations of ESM and two Chinese populations of ASM, including samples of unmated female adults and females after mating and oviposition. Of 129,286 unigenes identified, 306 were up-regulated in ASM samples relative to ESM, including genes involved in egg production. In contrast, 2,309 unigenes were down-regulated in ASM samples, including genes involved in energy production. Although a previous study found that ASM female flight was reduced after oviposition, a comparison of gene expression before and after mating and oviposition did not reveal any genes which were consistently up- or down-regulated in the two ASM populations.
Momentary predictors of binge eating episodes and heavy drinking episodes in individuals with comorbid binge eating and heavy drinking
Authors: Wilkinson Megan L. , Manasse Stephanie M. , Srivast Paakhi , Linden-Carmichael Ashley , Juarascio Adrienne S. 
Published: May 2022

Abstract
Purpose – The co-morbidity of binge eating and heavy drinking (BE+HD) is a serious concern due to the high prevalence rates and associated elevated severity. Clarifying the momentary factors that increase risk for binge eating and heavy drinking among BE+HD is important for expanding theoretical models of BE+HD and informing treatment recommendations. The current study used ecological momentary assessment (EMA) to compare the momentary processes maintaining binge eating between BE+HD and individuals with binge eating only (BE-only) and to identify the momentary risk factors for binge eating episodes and heavy drinking episodes among BE+HD. Methods – Participants (BE+HD: N = 14; BE-only: N = 37) were adults with clinically-significant binge eating who completed between 7 – 14 days of EMA prior to treatment. Results – The presence of food and within-day dietary restraint predicted higher odds of binge eating for both groups. Among BE+HD, the presence of alcohol and dietary restraint increased risk for subsequent binge eating and subsequent heavy drinking, and the absence of food increased risk for subsequent heavy drinking.Conclusion - These results offer preliminary support for treatment interventions for BE+HD that focus on reducing dietary restraint and teaching strategies for urge management in situations with palatable food or alcohol. Future research should study the maintenance mechanisms of BE+HD with larger, more diverse samples and using study design approaches with more experimenter control (i.e., laboratory experiments). Level of Evidence: Level IV, multiple time series without intervention
Noxa and Mcl-1 expression influence the sensitivity to BH3 mimetics that target Bcl-xL in patient-derived glioma stem cells
Authors: Vera Mariana Belén , Morris-Hanon Olivia , Nogueiras Germán Ignacio , Ripari Luisina Belén , Esqu Myrian Inés , Perez-Castro Carolina , Romorini Leonardo , Sevlever Gustavo Emilio , Scassa María Elida , Videla-Richardson Guillermo Agustín 
Published: May 2022

Abstract
The recurrence of Glioblastoma is partly attributed to the highly resistant subpopulation of glioma stem cells. A novel therapeutic approach focuses on restoring apoptotic programs in these cancer stem cells, as they are often deregulated. BH3-mimetics, targeting anti-apoptotic Bcl-2 family members, are emerging as promising compounds to sensitize cancer cells to antineoplastic treatments. Herein, we determined that the most abundantly expressed anti-apoptotic Bcl-2 family members, Bcl-xL and Mcl-1, are the most relevant in regulating patient-derived glioma stem cell survival. We exposed these cells to routinely used chemotherapeutic drugs and BH3-mimetics (ABT-263, WEHI-539, and S63845). We observed that the combination of BH3-mimetics targeting Bcl-xL with chemotherapeutic agents caused a marked increase in cell death and that this sensitivity to Bcl-xL inhibition correlated with Noxa expression levels. Interestingly, whereas co-targeting Bcl-xL and Mcl-1 led to massive cell death in all tested cell lines, down-regulation of Noxa promoted cell survival only in cell lines expressing higher levels of this BH3-only. Therefore, in glioma stem cells, the efficacy of Bcl-xL inhibition is closely associated with Mcl-1 activity and Noxa expression. Hence, a potentially effective strategy would consist of combining Bcl-xL inhibitors with chemotherapeutic agents capable of inducing Noxa, taking advantage of this pro-apoptotic factor.
Genetic testing of sperm donors in China: A survey of current practices
Authors: Huang Chuan , Wang Qi-Lin , Wu Hui-Lan , Luo Xue-Feng , Zhou Wen-Jun , Huang Zeng-Hui , Tang Yu-Ling , Zhang Xin-Zong , Zhu Wen-Bing 
Published: May 2022

Abstract
Background: The National Health and Family Planning Commission of China (NHFPCC) issued the “Measures for the Management of Human Sperm Banks,” which was revised in 2003 and is still in effect today. One of the standard guidelines is that potential donors undergo laboratory testing to exclude infectious and genetic diseases and karyotype analysis. However, patient demands for donor genetic testing have also increased, and only karyotype analysis to exclude genetic diseases is not sufficient to meet these demands.Materials and Methods: An electronic survey was distributed to twenty-seven sperm banks to examine donor genetic screening practices at sperm banks in China and to evaluate the qualifications and skills of genetic counselors at the banks. Twenty-six human sperm banks responded to a 32-question survey about their current practices related to genetic testing of sperm donors.Results: The 26 sperm banks reported that all qualified sperm donors undergo karyotype analysis; 22 banks (84.6%) collected three generations of family history from each qualified sperm donor; 10 (38.5%) reported that they attempted to accommodate special requests from donor semen recipients for particular genetic tests. Only 2 of the 26 (7.7%) sperm banks reported that they performed whole-exome sequencing. At all the sperm banks, consent for genetic testing was obtained as part of the overall contract for sperm donors. Nineteen (73.1%) sperm banks had genetic counselors on their staff, while six (23.1%) had no genetic counselors on their staff but had access to genetic counselors at the hospital. Only one (3.8%) sperm bank had no genetic counselors on their staff or at the hospital. Conclusions: The need for larger scale genetic testing of donors and recipients and an extensive panel of genetic tests specific to the Chinese population. Additionally, professionally trained geneticists must be employed as genetic counsellors so that the results of genetic tests and their implications can be explained to donors.
IGFL2-AS1-induced suppression of HIF-1α degradation promotes colorectal cancer cell proliferation by upregulating CA9
Authors: Qin Mengdi , Liu Qiang , Yang Wei , Wang Qiaofeng , Xiang Zheng 
Published: May 2022

Abstract
Purpose: The lncRNA IGFL2-AS1 is a known cancer-promoting factor in colorectal cancer (CRC); nonetheless, the mechanism of its carcinogenic effects has not yet been elucidated. This study elaborated the role and underlying molecular mechanism of IGFL2-AS1 in promoting CRC cell proliferation. Methods: IGLF2-AS1 expression levels in CRC tissue/normal tissue and CRC cell line/normal colon epithelial cell line were detected by quantitative real-time polymerase chain reaction. Cell Counting Kit-8, colony formation assays, and EdU assays were performed to assess the effect of IGFL2-AS1 knockdown or overexpression on the proliferative capacity of CRC cells. The expression relationship between IGFL2-AS1 and carbonic anhydrase 9 (CA9) and the CA9 expression level in CRC tissues and cells was verified by transcriptome sequencing, western blotting, and immunohistochemical staining. Treatment with MG132 and cycloheximide was utilized to explore the mechanism by which IGFL2-AS1 affects the hypoxia-inducible factor-1α (HIF-1α)/CA9 pathway. A nude mouse xenograft model was constructed to evaluate the effect of IGFL2-AS1 on CRC growth in vivo. Results: We discover that IGFL2-AS1 was sharply upregulated in CRC tumor tissues and cells. IGFL2-AS1 could functionally promote CRC cell proliferation in vitro and accelerate CRC occurrence in vivo. Mechanistic studies demonstrated that IGFL2-AS1 upregulated the CA9 level by affecting the degradation pathway of HIF-1α, which elucidates its pro-proliferative effect in CRC. The lncRNA IGFL2-AS1 mediated the inhibition of HIF-1α degradation in CRC and increased CA9 expression, thereby promoting CRC progression. Conclusion: Our findings suggested that IGFL2-AS1 is expected to be a new promising diagnostic marker and therapeutic target for CRC.
Dynamical Motions and Oscillations of a Quiescent Prominence Observed by IRIS and SDO/AIA
Authors: T. Jain Jacob P. , Maurya R. A. , K. Safna Banu 
Published: May 2022

Abstract
We studied the dynamical properties of a quiescent prominence using high-resolution observations provided by the Interface Region Imaging Spectroscopy (IRIS) and Atmospheric Imaging Assembly (AIA) onboard Solar Dynamics Observatory (SDO). IRIS's spectroscopic observations helped us compute the Doppler velocity maps in the prominence. The emission measure and temperature maps in the prominence regions are computed using the Differential Emission Measure (DEM) analysis of the EUV observations obtained from SDO/AIA. We employed the local correlation tracking (LCT) to find the plane-of-sky motion in the prominence. The prominence bubble was found to be rotating anti-clockwise with a rotation period of around 60 minutes when viewed from the top of it. We found dynamical motion 20 to 60 km s-1 in the prominence and its rotations. On the other hand, the central part of the prominence was making torsional rotations. This could be associated with upward propagating torsional Alfv\'en waves along the magnetic field lines. We also found a sizable helical motion in the upper part of the prominence with a linear speed of 6.35 km s-1. Further, the prominence was found to have significant oscillations in the frequency band 1.5 - 2.5 mHz, corresponding to the period range of 7 - 11 minutes with a dominant oscillation for around 10 minutes.
Study protocol: The OptiScreen-Study: Optimized psycho-oncological care – from screening to intervention
Authors: Zimmermann Tanja , Dreismann Lara , Ginger Viktoria , Wenzel Marit , Hornemann Beate , Dietzsch Franziska , Sura Charis , Bornhäuser Martin , Mehnert-Theuerkauf Anja , Heyne Svenja , Gockel Ines , Lordick Florian , Franzke Anke , Weitz Jürgen , Vogel Arndt 
Published: May 2022

Abstract
Adequate, needs-oriented psycho-oncological care contributes to reducing psychological distress in cancer patients and their relatives and improving quality of life. Regarding the precise determination of objective and subjective needs, there are often discrepancies in practice between the screening instrument completed by patients, the clinical impression of the treatment team, and the judgment of the psycho-oncology team. The present multicenter-study “OptiScreen”, involving three German Comprehensive Cancer Centers (Hannover, Leipzig, Dresden), aims to professionalize psychosocial screening to enable targeted and needs-based allocation to psycho-oncological support. Optimization and professionalization of the screening process will be achieved by training of oncological nursing staff to improve the targeted identification of distressed patients and provide them with needs-based psycho-oncological care. The non-randomized pre-post study will include inpatients with gastrointestinal cancers from the visceral oncology centers at the three sites. First, the comparison group (CG) will be assessed of N = 300. After completion of nursing training, the intervention group (IG) with N = 600 patients will be evaluated by validated questionnaires. The aim is to reduce barriers on both the patient and treatment side by promoting interdisciplinary dialogue and linking the screening with a personal consultation offer provided by the nurses, which should help to increase utilization and reduce patients' fears, shame and information deficits. It is not sufficient to establish a well-validated screening procedure, it also has to be feasible and useful in clinical practice. "OptiScreen" aims to improve the psycho-oncological care situation. In parallel, the study enables the professionalization of psycho-oncological care with the involvement of important professional groups (e.g. nursing) and thus aims to develop a "best practice model".
The shape of sunspots and activity cycles
Authors: Tlatov Andrey 
Published: May 2022

Abstract
The paper presents the results of the analysis of the geometric characteristics of sunspots for the period of 15-24 cycles of activity according to the data of Kislovodsk (1956-2021) and RGO (1918-1972). To study the shape of sunspots, we used the method of obtaining the average density of the distribution, as well as the average values of the ratio of the extent of the spots in latitude and longitude. The deviation of the shape of sunspots from the axisymmetric configuration is investigated. It was found that the spots, as a rule, have an ellipsoid shape, and the major axis of the ellipse, as a rule, is elongated along longitude and has a predominant slope to the equator, different in the Northern and Southern hemispheres. The relationship between the shape of sunspots in the current cycle and the amplitude of the next cycle of activity is found. The greater the elongation of the spots along the longitude in the current cycle, the more powerful the next cycle of activity will be.
CYP4F2 1347C&gt;T and GGCX 12970C&gt;G Polymorphisms as Determinants of Stable Warfarin Dose in Sudanese Patients of Heart Valve Replacement
Authors: Elsadig Ahmed Elhadi , Elamin Elwaleed Mohamed , Muddathir Abdel Rahim Mahmoud , Ali May Mohammed , Sherif NassrEldin M. A. 
Published: May 2022

Abstract
Purpose: This study intended to explore the contribution of CYP4F2 1347C>T and GGCX 12970C>G polymorphisms on warfarin dose requirements among Sudanese subjects.Methods: A total of 136 Sudanese patients of heart valve replacement receiving stable warfarin dose were recruited for this study. Blood samples were collected; DNA was extracted using phenol chloroform method. Genotyping for CYP4F2 1347C>T and GGCX 12970C>G polymorphisms was performed using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. The association of genotype with warfarin dose requirement was measured by Kruskal Wallis and Mann Whitney U tests. Genotype, age, gender, comorbidity and concurrent medication were tested as predictors of stable warfarin dose using univariate regression analysis. For all tests, p. values < 0.05 were considered statistically significant. Results: Frequencies of CYP4F2 1347C>T genotypes were 22.8% CC, 61% CT and 16.2% TT. The frequencies of C, T alleles were 0.533, 0.466 respectively which are deviated from Hardy Weinberg equilibrium (p. value = 0.008). Regarding GGCX 12970C>G genotyping, 96.9% were CC and 3% were CG. The frequencies of C, G alleles were 0.984 and 0.015 respectively which are in accordance with Hardy Weinberg equilibrium (p. value = 0.859). Insignificant differences in the mean daily warfarin dose between different genotype groups were observed (all p. values > 0.05). None of the studied variables was significant predictor of stable warfarin dose in this study population (p. values > 0.05).Conclusion: No significant contribution of CYP4F2 1347C>T and GGCX 12970C>G polymorphisms on warfarin dose requirements was observed in this study population.
Characterization of endophytic Streptomyces griseobrunneus Ahn75 and its potential for biocontrol and plant growth-promotion in rice
Authors: Fu Zujiao , Lei Ping , Hu Zhan , Yang Hua , Cheng Wei , Xiao Rong , Luo Rongjun , Wu Shandong , Shan Shiping , Guo Zhaohui 
Published: May 2022

Abstract

Plant endophyte Streptomyces are excellent candidates as biocontrol agents against the rice blast fungus, Magnaporthe oryzae. In this study, rice endophytic strain Ahn75 was isolated from healthy rice stem and identified as Streptomyces griseobrunneus by morphological and molecular characterization. Then the potential of strain Ahn75 for inhibition against M. oryzae and growth-promotion were evaluated using an in vitro assay, genome sequencing, and in vivo greenhouse pot experiments. Strain Ahn75 significantly inhibited the growth of M. oryzae, and its culture filtrate caused 80.88% mycelia growth inhibition, 78.26% spore germination inhibition and significant morphological alterations in M. oryzae. Meanwhile, strain Ahn75 also exhibited several growth-promoting properties, including phosphate and potassium solubilization, siderophore production, and nitrogen fixation. Genome sequencing results showed 40 gene clusters of secondary metabolites, including lactones, non-ribosomal peptide synthetases (NRPS), siderophores, polyketide antibiotics, terpenes, and peptides, that may synthesize active compounds against M. oryzae, and several genes related to plant growth promotion were exhibited in the genome of Ahn75. In greenhouse test, Ahn75 dramatically reduced rice leaf blast incidence by 59.76% and increased grain yield by 55.57% and 59.22% in wet and dry weight, respectively. These findings suggest that strain Ahn75 could be a potential biocontrol and growth-promoting agent for rice.