bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supratentorial ependymoma, zinc finger translocation-associated fusion positive, with extensive synaptophysin immunoreactivity arising from malignant transformation of clear cell ependymoma: A case report
Authors: Bethel Jacob A. , James Kenneth M. , Tavakoli Samon G. , Crownover Richard L. , Brenner Andrew J. , Papanastassiou Alexander M. , Gilbert Andrea R. 
Published: April 2022

Background:
We describe a case of a supratentorial ependymoma, zinc finger translocation-associated (ZFTA) fusion positive with extensive synaptophysin immunoreactivity arising from malignant transformation of an ependymoma with clear cell features in a patient with long-term follow-up.

Case Description:
A 55-year-old woman presented with seizures and ataxia 15 years after an initial resection of a clear cell ependymoma, Grade 2. Imaging demonstrated an enhancing right paracentral mass and the patient underwent biopsy and resection. Microscopic analysis showed regions of the tumor with morphological and immunohistochemical features typical of ependymoma, including perivascular pseudorosettes and focal dot- like epithelial membrane antigen positivity, as well as high-grade features. In addition, the neoplasm contained large nodular regions of clear cells exhibiting extensive synaptophysin immunoreactivity, suggestive of neural differentiation, and only focally positive immunoreactivity for glial markers. Electron microscopy showed poorly formed and ill-defined junctional complexes, but no cilia, microvilli, or dense granules were seen. Molecular profiling revealed the presence of a fusion between ZFTA (previously known as C11orf95) and RELA fusion.

Conclusion:
We report a case of extensive synaptophysin immunoreactivity in a ZFTA-RELA fusion-positive ependymoma that had undergone malignant transformation from a clear cell ependymoma and has long-term follow-up, contributing to the assessment of prognostic significance of synaptophysin immunoreactivity in supratentorial ependymoma, ZFTA fusion positive.
Partisipasi masyarakat perbatasan Indonesia-Malaysia dalam melanjutkan pendidikan: Studi di perbatasan Aruk Kabupaten Sambas
Authors: Purnama Desca Thea , Chainar Chainar , Niko Nikodemus 
Published: April 2022

<p class="JOURNALABSTRACT-KEY"><span lang="id">Tujuan dalam penelitian ini yaitu menganalisa partisipasi masyarakat perbatasan dalam melanjutkan pendidikan pada jenjang atau satuan pendidikan menengah. Keadaan pendidikan yang cukup memprihatinkan juga di alami wilayah perbatasan antara Indonesia dengan Malaysia di Provinsi Kalimantan Barat tepatnya di Kecamatan Aruk Kabupaten Sambas. Jenis penelitian yang digunakan dalam penelitian ini adalah kualitatif deskriptif. Adapun penelitian ini dilakukan dimulai sejak Oktober 2020. Kemudian, penelitian lapangan dilaksanakan pada bulan Februari tahun 2021. Data penelitian bersumber dari data primer dan data sekunder. Teknik analisis data yang digunakan yaitu analisis data kualitatif, dimana melalui proses pengumpulan data, intepretasi dan penulisan laporan penelitian. Kemudian teknik keaabsahan data adalah triangulasi sumber. Pengumpulan data primer dengan wawancara dan observasi, sedangkan data sekunder didapatkan melalui penelusuran daring, instansi kecamatan dan desa. Temuan penelitian ini mengungkapkan bahwa partisipasi pendidikan di wilayah perbatasan mengalami perbaikan ke arah yang lebih maju, dimana sebagian masyarakat sudah memiliki pola pikir yang semakin maju dengan melihat pendidikan bukan hanya sekedar keharusan yang dicanangkan oleh negara, akan tetapi masyarakat mulai berpikir bahwa pendidikan merupakan hal yang sangat penting dalam menentukan nasib. Dengan berpendidikan artinya mereka memiliki kesempatan untuk melakukan perubahan kehidupan.</span></p>
DIGITALIZATION OF EDUCATION IN RUSSIA: OPPORTUNITIES AND LIMITATIONS
Authors: Новикова Ксения Владимировна , Добровлянин Вадим Дмитриевич 
Published: April 2022

Цифровизация образования в России на сегодняшний день является наиболее актуальным вызовом социально-образовательной среды. Новый подход требует нового образа мышления субъектов в образовательном процессе. Статья посвящена новым возможностям, которые появляются в процессе цифровой трансформации, а также ограничениям цифровизации образования. Целью исследования является анализ основных изменений, наблюдаемых в процессе цифровизации образовательной среды и актуализации основных тенденций. Научная новизна полученных результатов заключается в проведенном исследовании студентов 1-4 курсов бакалавриата: на предмет отношения к дистанционному формату обучения, об основных изменениях в отношении к данному формату в зависимости от учебного курса.
The digitalization of education in Russia today is the most pressing challenge for the social and educational environment. A new approach requires a new way of thinking for all participants in the educational process. This article is devoted to new educational opportunities that appear in the process of digital transformation, as well as the limitations of digitalization of education. The author updates the current trends in the educational environment, conducts a study of 1-4 year undergraduate students on the subject of attitudes towards the distance learning format and discusses the prospects for the further development of education.
Articulación de saberes matemáticos en el álgebra: Transición de lo concreto a lo abstracto
Authors: Pliego-Pastrana Patricia , Rondero-Guerrero Carlos , Tetlalmatzi-Montiel Margarita , Castillo-Gálvez Angélica María 
Published: April 2022

Este trabajo tiene por objetivo analizar algunas de las posibles causas que originan las dificultades del aprendizaje de las matemáticas por parte de los estudiantes. Partimos de considerar acerca de la complejidad de los objetos matemáticos, en la cual están involucrados, entre otros, aspectos epistemológicos, históricos y cognitivos. Tal complejidad se agudiza cuando los estudiantes ingresan al nivel medio superior, y no saben articular adecuadamente los saberes matemáticos, lo que les podría permitir realizar en forma más apropiada la transición entre el pensamiento concreto y el pensamiento abstracto. Se discute brevemente la vinculación entre Neuroeducación y Educación Matemática, lo que arroja elementos conceptuales adicionales sobre la problemática antes descrita, en donde se incluye la generalización de los saberes matemáticos. El estudio de lo anteriormente mencionado puede permitir reducir en parte los índices de reprobación y deserción escolar, relacionados con el desinterés de los estudiantes en el estudio de las matemáticas, y en general de las Ciencias Exactas.
Emergency Transport Crew: Post-Traumatic Stress Disorder Prevention Program
Authors: Dearing Heather , Kippenbrock Thomas 
Published: April 2022

Background: The incidences of post-traumatic stress disorder (PTSD) among critical care nurses, emergency room nurses, and paramedics range from 20 to 33%. PTSD is associated with a lower quality of life (QOL), occupational impairments, physical health decline, and increases the risk of premature death. Research supports prevention and surveillance measures for post-traumatic stress disorder in emergency medical service providers, but the practice is not routinely done.
Methods: A multi-purpose quality improvement project focused on educating transport crew members about PTSD. Other interventions emphasized anti-stigma lessons, resiliency assistance, and coping skills training. The pilot provided surveillance efforts, employed an early organizational PTSD recognition, and immediate debriefing for at-risk personnel at three Air Evac Lifeteam bases.
Results: After the QI interventions, most crew members’ overall post-test PCL-5 scores were lowered by 12.5%. Another measure of the QI success was the Professional Quality of Life score improvement. Specially, the compassion satisfaction average level increased by 14% and the average burnout level decreased by of 15%.
Conclusions: The QI project demonstrated the transport crew members’ well-being can be positively influenced by a PTSD prevention and surveillance program. These interventions offer a promising reduction in the prevalence of stress and PTSD. A nationwide practice change with these project interventions could improve the mental health of helicopter emergency medical personnel.
Laboratory-instrumental and histological data characteristic of myocardial changes in COVID-19
Authors: Tsokolov A. V. , Iliin I. B. , Umaev R. H. , Vertelkin A. V. 
Published: April 2022

The nature and mechanisms of damage to organs and tissues during SARS-Cov-2 infection in certain areas remain unclear over the past 2 years.Material and methods. The study included 70 patients who underwent COVID-19 and were divided into 4 groups depending on the volume of lung damage according to the results of computed tomography. Assessment of echocardiographic parameters of longitudinal myocardial deformation (speckle-tracking) was performed on the 25–40th day of diagnosis using the GE Vivid S70 device. The histological picture of changes in the myocardium is given taking into account 30 protocols of autopsy of patients with severe and extremely severe course of the disease.Results. Myocardial damage in the form of a violation of the longitudinal strain index (as an indirect sign of myocarditis in a number of patients, but not in those with COVID-19) was most often (in 83% of cases) recorded in the CT-3 group with a lung lesion volume of 51–75%. A nonspeciﬁc histological picture in the form of edema of myoﬁbrils, pallor of the nuclei, edema of the sarcoplasm, dystrophic changes clearly cannot be interpreted as myocarditis, and such a diagnosis has never been made, especially coronavirus. Hypertrophy of cardiomyocytes indicates the presence of chronic hypoxia, ischemia, metabolic changes (to a greater extent as a background from concomitant pathology — diabetes mellitus, hypertension, coronary artery disease). None of the examined patients who underwent an immunological blood test for the presence of “antibodies to the myocardium” were found to have such.Conclusion. Taking into account the data obtained, we can only talk about non-speciﬁc changes in organs and tissues against the background of COVID-19, including in the myocardium. However, myocarditis was not veriﬁed in any of the cases.
Educação em saúde na Unidade de terapia Intensiva Neonatal
Authors: Santos Aliniana da Silva , Rodrigues Lidiane do Nascimento , Da Silva Wandra Camila Penaforte , Brito Larissa Ludmila Monteiro de Souza , Viana Maria Corina Amaral , Chaves Edna Maria Camelo 
Published: April 2022

O objetivo é identificar na literatura nacional e internacional as ações de educação em saúde desenvolvidas com pais de recém-nascidos hospitalizados em Unidade de Terapia Intensiva Neonatal e suas implicações. Trata-se de uma revisão integrativa da literatura realizada nas seguintes bases de dados: LILACS, BDENF, MEDLINE via PUBMED, Web of Science, CINAHL e SCOPUS, tendo como questão norteadora: quais os efeitos das tecnologias educacionais utilizadas pelos profissionais de saúde para os pais de recém-nascidos em Unidade de Terapia Intensiva Neonatal? A seleção foi realizada mediante leitura minuciosa de títulos, resumos e texto completo. Foram analisados 15 estudos os quais destacaram diferentes estratégias de educação em saúde, tendo como implicação o incentivo à participação dos pais nos cuidados ao filho e sobre as decisões relativas à assistência em saúde ao bebê, além de promover a redução dos sentimentos negativos sobre a hospitalização. Assim, foi possível melhorar o conhecimento dos pais relacionado a ambiência da Unidade de Terapia Intensiva Neonatal. Ficou evidente o número reduzido de estudos brasileiros com aplicação de educação em saúde para apoiar os pais durante a internação do filho prematuro, apresentando assim uma lacuna de conhecimento que pode ser suprida a partir da sensibilização dos profissionais e pesquisadores a fim de aplicar medidas de apoio aos pais.
Psycholinguistics of Organizational Phenomena: A Case of the Managerial Culture Study
Authors: Shymko Vitalii 
Published: April 2022

Purpose. This article is devoted to the case study of relevant linguacultural stereotypes of the particular organization’s managerial culture and based on corresponding results the inquiry of the discourses formation features associated with the lexico-semantic meanings dispersion of (Foucault).
Methods and Procedure of Research. Top managers of a large Ukrainian enterprise (67 respondents) were asked to arbitrarily describe the following concepts – “manager”, “subordinate”, “managerial style”. Each concept was differentiated according to the principle of the lexico-semantic opposition (“productive – counterproductive”). The obtained set of texts was lemmatized and a frequency analysis of the lemmas was carried out as well. Collocations were also evaluated, in particular, repeated n-grams were identified. In the further analysis were used all detected n-grams and those lemmas, the observed frequencies of which statistically significantly exceeded the expected ones.
Results. Discourse formation features are determined by the paradigmatic relations of lexico-semantic units (words) and their semantic linear compatibility. The paradigmatic dispersion of a discourse is represented by the quality of connections between lemmas according to the criterion of the paradigm types to be found. Also informative is the assessment of the lemmas number (granularity of the discourse) and the spectrum diversity of paradigmatic relations in the discourse. These parameters reflect the properties of homogeneity/complexity of discourse meanings dispersion. The syntagmatic dissemination of discourse is manifested by the features of the words semantic linear interrelationship in each n-gram. This parameter reflects the quality of rationalizations (verbal-logical chains) associated with the corresponding discourses. The length of n-grams (the number of words) is also indicative – the higher n, the more differentiated the discourse is and vice versa. Matching the words semantics in n-grams with lemmas allows one to draw a conclusion regarding the internal consistency (integration) of the discourse.
Conclusions. Psycholinguistic tools can be effectively used in an organizational phenomena study. In particular, the frequency analysis of lemmas, their lexico-semantic evaluation, as well as the qualitative analysis of n-grams in the problem-targeted texts of respondents allows one to solve applied research issues related to the assessment of current linguacultural trends in an organization and understanding their possible causes. Managerial culture, as a linguacultural phenomenon, is represented by a set of stably reproduced discourses in the process of the organization’s functioning. At the same time, discourses are constituted by the dispersion of meanings (words), which is being realized in two linguistic dimensions – paradigmatic and syntagmatic ones.
The Pragmatic Functions of the Idiomatic Expression Yalla in Jordanian Spoken Arabic
Authors: Hamdan Jihad , Hammouri Dina 
Published: April 2022

Purpose. The study reported here aims to identify and classify the pragmatic functions of the frequently used idiomatic expression Yalla, literally ‘let’s’, in Jordanian Spoken Arabic (JSA).
Method. The data were collected from 145 university students (males and females) enrolled in different specialisms at two higher education institutions, viz., the University of Jordan and Jadara University. All participants are native speakers of Jordanian Spoken Arabic; their ages ranged from 18 to 22 years. They were divided into three groups; 14 participants gave the data in the mini questionnaire stage which was used to guide and inform proper data collection, 86 completed the extended data collection questionnaire and 45 undertook the acceptability agreement/ judgment task.
Results. The study reveals that Yalla conveys 23 pragmatic functions: showing approval / acceptance, signaling the start of an action, spreading enthusiasm, suggesting, commanding/ ordering someone, expediting/ urging, expressing surrender or submission, announcing the onset of a new stage, requesting approval, rest assuring, prompting someone to act in line with an established routine, advising coupled with warning, asking for patience/calming someone down, encouraging/ cheering, drawing attention, reminding, wishing, stimulating, underestimating the importance of a complaint, ridiculing/ mocking, expressing comfort, showing emphasis in addition to showing anger and boredom.
Conclusions. The study concludes that the functions of the idiomatic expression Yalla are not equally frequent; nor are they equally acceptable by the Jordanian youth. This is evident in the results of the acceptability judgment task undertaken by the participants, an indication that some of them are more deeply entrenched in the Jordanian youth community than others. The study suggests that future research may investigate the pragmatic functions of Yalla in social contexts and situations other than those examined in this study. It may also involve older age groups as Yalla is more likely to be age sensitive; education level may also turn out to impact the use of this idiomatic expression. Furthermore, as the focus of this study is on Jordanian Spoken Arabic, future research may target the pragmatic functions of Yalla in other Arabic spoken varieties, e.g., Egyptian, Syrian and Saudi, among others.
Endovascular treatment in patients with coma that developed secondary to acute basilar artery occlusion
Authors: Yue Chengsong , Deng Wei , Liu Juan , Luo Xiaojun , Miao Jian , Liu Jincheng , Zheng Bo , Du Jie , Zhang Yuxian , Yang Shunyu , Zi Wenjie , Li Fengli 
Published: April 2022

OBJECTIVE
This study aimed to evaluate the efficacy of endovascular treatment (EVT) in patients with secondary coma following acute basilar artery occlusion (comatose patients) and to identify the impact of the Glasgow Coma Scale (GCS) score on medical decisions.

METHODS
Patients from the Endovascular Treatment for Acute Basilar Artery Occlusion study were divided into comatose and noncomatose cohorts. The primary outcome was favorable functional independence (modified Rankin Scale [mRS] scores 0–3). The safety outcome was 90-day mortality. Subgroup analysis was performed to identify populations best suited for EVT. Multivariate logistic regression was used to identify independent predictive factors of clinical outcomes.

RESULTS
Comatose patients who underwent EVT had more favorable functional outcomes and lower mortality compared with those who underwent standard medical treatment (functional outcomes: 15.98% vs 4.17%; mortality: 62.72% vs 82.29%). Moreover, EVT was associated with better outcomes in the cohort with GCS scores of 6–8 (mRS scores 0–3, 25.33% and mortality, 41.33%) than in the cohort with GCS scores of 3–5. Multivariate analysis indicated that EVT was an independent factor for favorable functional outcomes (adjusted OR 8.921, 95% CI 2.330–34.158) and mortality (adjusted OR 0.189, 95% CI 0.092–0.411) in comatose patients. The initial GCS score was an independent factor for favorable functional outcomes (adjusted OR 1.402, 95% CI 1.115–1.763) and mortality (adjusted OR 0.613, 95% CI 0.499–0.752) in comatose patients with EVT.

CONCLUSIONS
EVT significantly improved the prognosis of comatose patients, and patients with GCS scores of 6–8 were found to benefit more from EVT than those with GCS scores of 3–5. The initial GCS score was an independent predictive factor for prognosis in comatose patients.
An independent, external validation and component analysis of the Surviving Penetrating Injury to the Brain score for civilian cranial gunshot injuries
Authors: Johnson Mark D. , Stolz Uwe , Carroll Christopher P. , Yang George L. , Andaluz Norberto , Foreman Brandon , Kreitzer Natalie , Goodman Michael D. , Ngwenya Laura B. 
Published: April 2022

OBJECTIVE
The Surviving Penetrating Injury to the Brain (SPIN) score utilizes clinical variables to estimate in-hospital and 6-month mortality for patients with civilian cranial gunshot wounds (cGSWs) and demonstrated good discrimination (area under the receiver operating characteristic curve [AUC] 0.880) in an initial validation study. The goal of this study was to provide an external, independent validation of the SPIN score for in-hospital and 6-month mortality.

METHODS
To accomplish this, the authors retrospectively reviewed 6 years of data from their institutional trauma registry. Variables used to determine SPIN score were collected, including sex, transfer status, injury motive, pupillary reactivity, motor component of the Glasgow Coma Scale (mGCS), Injury Severity Score (ISS), and international normalized ratio (INR) at admission. Multivariable logistic regression analysis identified variables associated with mortality. The authors compared AUC between models by using a nonparametric test for equality.

RESULTS
Of the 108 patients who met the inclusion criteria, 101 had all SPIN score components available. The SPIN model had an AUC of 0.962. The AUC for continuous mGCS score alone (0.932) did not differ significantly from the AUC for the full SPIN model (p = 0.26). The AUC for continuous mGCS score (0.932) was significantly higher compared to categorical mGCS score (0.891, p = 0.005). Use of only mGCS score resulted in fewer exclusions due to missing data. No additional variable included in the predictive model alongside continuous mGCS score was a significant predictor of inpatient mortality, 6-month mortality, or increased model discrimination.

CONCLUSIONS
Given these findings, continuous 6-point mGCS score may be sufficient as a generalizable predictor of inpatient and 6-month mortality in patients with cGSW, demonstrating excellent discrimination and reduced bias due to missing data.
Comorbidity Scores and Machine Learning Methods Can Improve Risk Assessment in Radical Cystectomy for Bladder Cancer
Authors: Wessels Frederik , Bußoff Isabelle , Adam Sophia , Kowalewski Karl-Friedrich , Neuberger Manuel , Nuhn Philipp , Michel Maurice S. , Kriegmair Maximilian C. 
Published: April 2022

BACKGROUND: Pre-operative risk assessment in radical cystectomy (RC) is an ongoing challenge especially in elderly patients. OBJECTIVE: To evaluate the ability of comorbidity indices and their combination with clinical parameters in machine learning models to predict mortality and morbidity after RC. METHODS: In 392 patients who underwent open RC, complication and mortality rates were reported. The predictive values of the age-adjusted Charlson Comorbidity index (aCCI), the Elixhauser Index (EI), the Physical Status Classification System (ASA) and Gagne’s combined comorbidity Index (GCI) were evaluated using regression analyses. Various machine learning models (Gaussian naïve bayes, logistic regression, neural net, decision tree, random forest) were additionally investigated. RESULTS: The aCCI, ASA and GCI showed significant results for the prediction of complications (χ2 = 8.8, p < 0.01, χ2 = 15.7, p < 0.01 and χ2 = 4.6, p = 0.03) and mortality (χ2 = 21.1, p < 0.01, χ2 = 25.8, p < 0.01 and χ2 = 2.4, p = 0.04) after RC while the EI showed no significant prediction. However, areas under receiver characteristic curves (AUROCs) revealed good performance only for the prediction of mortality by the aCCI and ASA (0.81 and 0.78, CGI 0.63) while the prediction of complications was poor (aCCI 0.6, ASA 0.63, CGI 0.58). The combination of ASA, age, body mass index and sex in machine learning models showed a better prediction. Gaussian naïve bayes (0.79) and logistic regression (0.76) showed the best performance using a hold-out test set. CONCLUSIONS: The ASA and aCCI show good prediction of mortality after RC but fail predicting complications accurately. Here, the combination of comorbidity indices and clinical parameters in machine learning models seems promising.