bluuebunny/crossref_metadata_2025_split huggingface dataset:
Causal Association of Inflammatory Bowel Disease on Anorexia Nervosa: A Two-sample Mendelian Randomization Study
Authors: Jiang Rui , Zeng Ruijie , Zhuo Zewei , Wu Huihuan , Yang Qi , Li Jingwei , Leung Felix W , Sha Weihong , Chen Hao 
Published: August 2022

AbstractBackgroundAnorexia nervosa (AN) is a severe and complex psychiatric disorder with the highest mortality rate of all psychiatric disorders. Previous observational studies have comprehensively indicated an association between inflammatory bowel disease (IBD) and AN, but the causal effect remains unclear. We aimed to test the hypothesis that a causal relationship exists between IBD and the risk of AN.MethodsBased on published open genome-wide association study summary statistics, the single nucleotide polymorphisms (SNPs) of IBD, including ulcerative colitis (UC) and Crohn’s disease (CD), were selected as genetic instrumental variables. Two-sample Mendelian randomization (MR) analyses were conducted to infer the causal relationship between IBD and AN. The methods included inverse variance weighted (IVW), MR-Egger regression, weighted median estimator, weighted mode and MR Pleiotropy RESidual Sum and Outlier (MR-PERSSO). Furthermore, various sensitivity analyses were conducted to assess the robustness of our results.ResultsThe primary analysis IVW suggested that genetically predicted IBD were positively casually associated with AN risk (NSNP= 12, odds ratio [OR]: 1.143, 95% confidence interval [CI]: 1.032-1.266,P= 0.01). In subgroups, consistent positive causal associations with AN risk might show in UC (NSNP= 6, OR: 1.153, 95% CI: 1.022-1.301,P= 0.021), and CD (NSNP= 4, OR: 1.153, 95% CI: 1.008-1.319,P= 0.037). NO heterogeneity and pleiotropy were presented through sensitivity analysis and guaranteed credible and robust estimates.ConclusionOur study identifies that patients diagnosed with IBD, including UC and CD, could be causally associated with an increased risk of AN. It may have clinical benefits for early detection of AN and clinical decisions on management of IBD patients.
Weak parent-of-origin expression bias: Is this imprinting?
Authors: Edwards Carol A. , Watkinson William M. D. , Telerman Stephanie B. , Hülsmann Lisa C. , Hamilton Russell S. , Ferguson-Smith Anne C. 
Published: August 2022

AbstractIn mouse and human, genes subjected to genomic imprinting have been shown to function in development, behaviour, and post-natal adaptations. Failure to correctly imprint genes in human is associated with developmental syndromes, adaptive and metabolic disorders during life as well as numerous forms of cancer. In recent years researchers have turned to RNA-seq technologies applied to reciprocal hybrid strains of mice to identify novel imprinted genes, causing a 3-fold increase in genes reported as having a parental origin specific expression bias. The functional relevance of parental origin-specific expression bias is not fully appreciated especially since many are reported with only minimal parental bias (e.g. 51:49). Here we present an in-depth meta-analysis of previously generated RNA-seq data and show that the methods used to generate and analyse libraries greatly influence the calling of allele-specific expression. Validation experiments show that most novel genes called with parental-origin specific allelic bias are artefactual, with the mouse strain contributing a larger effect on expression biases than parental origin. Of the weak novel genes that do validate, most are located at the periphery of known imprinted domains, suggesting they may be affected by local allele- and tissue-specific conformation. Together these findings highlight the need for robust tools, definitions, and validation of putative imprinted genes to provide meaningful information within imprinting databases and to understand the functional and mechanistic implications of the process.
Long-term effect of forest harvesting on boreal species assemblages under climate change
Authors: Bouderbala Ilhem , Labadie Guillemette , Béland Jean-Michel , Tremblay Junior A. , Boulanger Yan , Hébert Christian , Desrosiers Patrick , Allard Antoine , Fortin Daniel 
Published: August 2022

AbstractLogging is the main human disturbance impacting biodiversity in forest ecosystems. However, the impact of forest harvesting on biodiversity is modulated by abiotic conditions through complex relationships that remain poorly documented. Therefore, the interplay between forest management and climate change can no longer be ignored. Our aim was to study the expected long-term variations in the assemblage of bird and beetle communities following modifications in forest management under different climate change scenarios. We developed species distribution models to predict the occurrence of 87 species of birds and beetles in eastern Canadian boreal forests over the next century. We simulated three climate scenarios (baseline, RCP4.5 and RCP8.5) under which we varied the level of harvesting. We also analyzed the regional assemblage dissimilarity by decomposing it into balanced variations in species occupancy and occupancy gradient. We predict that forest harvesting will alter the diversity by increasing assemblage dissimilarity under all the studied climate scenarios, mainly due to species turnover. Species turnover intensity was greater for ground-dwelling beetles, probably because they have lower dispersal capacity than flying beetles or birds. A good dispersal capacity allows species to travel more easily between ecosystems across the landscape when they search for suitable habitats after a disturbance. Regionally, an overall increase in the probability of occupancy is projected for bird species, whereas a decrease is predicted for beetles, a variation that could reflect differences in ecological traits between taxa. Our results further predict a decrease in the number of species that increase their occupancy after harvest under the most severe climatic scenario for both taxa. We anticipate that under severe climate change, increasing forest disturbance will be detrimental to beetles associated with old forests but also with young forests after disturbances.
Report of mutation biases mirroring selection in Arabidopsis thaliana unlikely to be entirely due to variant calling errors
Authors: Monroe J. Grey , Murray Kevin D. , Xian Wenfei , Carbonell-Bejerano Pablo , Fenster Charles B. , Weigel Detlef 
Published: August 2022

SUMMARYIt has recently been proposed that the uneven distribution of epigenomic features might facilitate reduced mutation rate in constrained regions of the Arabidopsis thaliana genome, even though previous work had shown that it would be difficult for reduced mutation rates to evolve on a gene-by-gene basis. A solution to Lynch’s equations for the barrier imposed by genetic drift on the evolution of targeted hypomutation can, however, come from epigenomic features that are enriched in certain portions of the genome, for example, coding regions of essential genes, and which simultaneously affect mutation rate. Such theoretical considerations draw on what is known about DNA repair guided by epigenomic features. A recent publication challenged these conclusions, because several mutation data sets that support a lower mutation rate in constrained regions suffered from variant calling errors. Here we show that neither homopolymer errors nor elevated mutation rates at transposable elements are likely to entirely explain reported mutation rate biases. Observed mutation biases are also supported by a meta-analysis of several independent germline mutation data sets, with complementary experimental data providing a mechanistic basis for reduced mutation rate in genes and specifically in essential genes. Finally, models derived from the drift-barrier hypothesis demonstrate that mechanisms linking DNA repair to chromatin marks and other epigenomic features can evolve in response to second-order selection on emergent mutation biases.
The net charge of the K-loop regulates KIF1A superprocessivity by enhancing microtubule affinity in the one-head-bound state
Authors: Zaniewski Taylor M. , Hancock William O. 
Published: August 2022

AbstractKIF1A is an essential neuronal transport motor protein in the kinesin-3 family, known for its superprocessive motility. We determined that superprocessivity of KIF1A dimers originates from a unique structural domain, the lysine rich insertion in loop-12 termed the ‘K-Loop’, which enhances electrostatic interactions between the motor and the microtubule. In 80 mM PIPES buffer, replacing the native loop-12 of KIF1A with that of kinesin-1, resulted in a 6-fold decrease in run length, and adding additional positive charge to loop-12 enhanced the run length. Interestingly, swapping the KIF1A loop-12 into kinesin-1 did not enhance its run length, consistent with the two motor families using different mechanochemical tuning to achieve persistent transport. To investigate the mechanism by which the KIF1A K-loop enhances processivity, we used microtubule pelleting and single-molecule dwell times assays in ATP and ADP. First, the microtubule affinity was similar in ATP and in ADP, consistent with the motor spending the majority of its cycle in a weakly-bound state. Second, the microtubule affinity and single-molecule dwell time in ADP were 6-fold lower in the loop-swap mutant compared to wild type. Thus, the positive charge in loop-12 of KIF1A enhances the run length by stabilizing the motor binding in its vulnerable one-head-bound state. Finally, through a series of mutants with varying positive charge in the K-loop, we found that the KIF1A processivity is linearly dependent on the charge of loop-12.
A novel approach for candlestick technical analysis using a combination of the support vector machine and particle swarm optimization
Authors: Mahmoodi Armin , Hashemi Leila , Jasemi Milad , Laliberté Jeremy , Millar Richard C. , Noshadi Hamed 
Published: August 2022

PurposeIn this research, the main purpose is to use a suitable structure to predict the trading signals of the stock market with high accuracy. For this purpose, two models for the analysis of technical adaptation were used in this study.Design/methodology/approachIt can be seen that support vector machine (SVM) is used with particle swarm optimization (PSO) where PSO is used as a fast and accurate classification to search the problem-solving space and finally the results are compared with the neural network performance.FindingsBased on the result, the authors can say that both new models are trustworthy in 6 days, however, SVM-PSO is better than basic research. The hit rate of SVM-PSO is 77.5%, but the hit rate of neural networks (basic research) is 74.2.Originality/valueIn this research, two approaches (raw-based and signal-based) have been developed to generate input data for the model: raw-based and signal-based. For comparison, the hit rate is considered the percentage of correct predictions for 16 days.
CEO characteristics and firm performance: evidence from private listed firms in China
Authors: Rahman Md Jahidur , Chen Xianxian 
Published: August 2022

Purpose
This study aims to examine the effect of the chief executive officer (CEO) characteristics on corporate performance in private listed firms in China.

Design/methodology/approach
Fixed effects regressions are used to explore the connection of CEO age, tenure, political connection, duality and gender with firm performance. The final panel data sample consists of 16,010 firm-year observations from 2010 to 2020, including A-share private firms listed in the Shenzhen and Shanghai Stock Exchanges.

Findings
Five hypotheses are proposed, and results show that certain CEO characteristics, such as age, tenure and political connection, are positively related to corporate performance. Contrary to expectations, CEO duality and gender do not affect firm performance.

Originality/value
Findings present implications for future research on corporate governance and political connections of private listed firms.
Conducted EMI analysis and filters design for a high-low voltage DC/DC converter based on GaN HEMTs in electric vehicle
Authors: Qiao Yiwei , Yang Wenrong , Huo Tianchen , Chen Guohang , Zhang Haojie , Luan Junling 
Published: August 2022

Purpose
The purpose of this paper is to study conducted electromagnetic interference (EMI) of the high-low voltage DC/DC converter based on GaN high-electron-mobility transistors (HEMTs) in electric vehicle, and design EMI filters to suppress the conducted EMI.

Design/methodology/approach
The conducted EMI propagation model is established through simulation and analysis studying the influences of parasitic parameters, operation mode, output power and near-field capacitive coupling effects on conducted EMI of the DC/DC converter and comparing the suppression effects of EMI filters with different topologies to select the best EMI filter.

Findings
It is shown that parasitic parameters, operation mode, output power and near-field capacitive coupling effects can affect the conducted EMI of the DC/DC converter, and EMI filters of the CLC topology can effectively suppress the conducted EMI below the limit of CISPR 25.

Originality/value
Analysis of conducted EMI and design of EMI filters greatly facilitate further explorations and studies on EMI problems of the high-low voltage DC/DC converter based on GaN HEMTs.
Development of long-term B2B customer relationships: the role of self-disclosure and relational cost/benefit evaluation
Authors: Koponen Jonna Pauliina , Julkunen Saara Maria 
Published: August 2022

Purpose
This paper aims to explore how and why salespeople enhance or hinder long-term business-to-business (B2B) customer relationships at the interpersonal level by considering self-disclosure and relational cost and reward evaluations.

Design/methodology/approach
Data from interviews (N = 47) with B2B sales professionals were analyzed, focusing on the shift of the phases in long-term B2B customer relationships.

Findings
Long-term B2B customer relationships evolve at the interpersonal level through a process of continuous relational cost and reward evaluation, self-disclosure and business disclosure in three phases: becoming business partners, collaborative partners and collaborative and personal partners. The reward evaluations progress from being business related to including even more relational benefits. Disclosure progresses through general business disclosure and general self-disclosure; strategic business disclosure and personal life self-disclosure; and synergistic business disclosure and private self-disclosure.

Research limitations/implications
The long-term B2B customer relationships could be studied at the interpersonal level from the customer’s perspective. Self-disclosure could be studied in cross-cultural settings as well as gender differences should be considered in future studies. Business and social penetration theory could be applied to investigate different types of relationships and other professional relationships, such as those between employers and employees. It would be important to test whether the business-related and self-disclosure subtypes apply to the development of other types of professional relationships or whether other disclosure subtypes exist. The authors recommend exploring salespeople’s and customers’ privacy management strategies in multiple communication channels.

Practical implications
Managers may apply the results of this study in their customer relationship management and sales training.

Originality/value
The findings outline a contextual extension of social penetration theory.
Can customer participation promote hospitality frontline employees’ extra-role service behavior?
Authors: Xu Angela J. , Zhu Ting Ting , Loi Raymond , Chow Cheris W.C. 
Published: August 2022

Purpose
Drawing on and extending the socially embedded model of thriving, this paper aims to investigate how and when customer participation promotes hospitality frontline employees’ engagement in extra-role service behavior.

Design/methodology/approach
A two-wave questionnaire survey was carried out among frontline service employees and their immediate supervisors in a four-star business hotel in Eastern China. Path analysis using Mplus 8.3 examined a multilevel moderated mediation model.

Findings
Customer participation has a positive effect on frontline employees’ experience of thriving, which in turn promotes their engagement in extra-role service behavior. Nevertheless, supervisors’ negative affect weakens the positive effect of customer participation.

Practical implications
Hotels could implement employee assistance programs, arrange training on emotional regulation and positive psychology and create a fun work environment to help alleviate supervisors’ experience of negative affect so as to lessen its adverse effect on frontline employees’ perception of customer participation.

Originality/value
First, this work is one of the few studies exploring how customer participation affects frontline employees’ well-being (in terms of thriving) and extra-role service behavior, which advances extant value co-creation literature. Second, the moderating role of supervisors’ negative affect enriches the limited understanding of when customer participation might not bring firm benefits. Third, by uncovering customer participation as an antecedent of employee thriving, this study extends thriving research that only attends to contexts located within organizations.
Relationship of ethical leadership, organizational culture, corporate social responsibility and organizational performance: a test of two mediation models
Authors: Alkhadra Wafa Awni , Khawaldeh Sadam , Aldehayyat Jehad 
Published: August 2022

PurposeThe sound leadership style can be indicative of organizational success and explanatory of quality performance. Besides this, there are various factors that can impact organizational performance. To this end, this study aims to investigate the effect of ethical leadership on organizational performance, with the mediating role of corporate social responsibility (CSR) and organizational culture.Design/methodology/approachThe service sector in Jordan was targeted by this research, and data were collected from 371 middle-level and top-level managers working in service companies. These responses were analyzed by using analysis of a moment structure.FindingsThe result conveyed that ethical leadership does not only influence organizational performance, but it also, and positively so, affects the organizational culture and CSR. In addition, CSR and organizational culture significantly mediate the relationship between ethical leadership and organizational performance.Practical implicationsThe findings of this study are a guide for managers and owners of service companies who are aiming to enhance organizational performance. If they follow the ethical leadership approach and emphasize CSR initiatives and organizational culture, they can attain, and naturally so, the maximum level of organizational performance.Originality/valueTo the best of the authors’ knowledge, this research paper is the first to analyze ethical leadership in the context of the service sector in Jordan and highlight its influence on organizational culture, CSR and ultimately organizational performance. Moreover, it examined the mediating effects of organizational culture and CSR between ethical leadership and organizational performance.
The structure and information spread capability of the network formed by integrated fitness apps
Authors: Vermeulen Euodia , Grobbelaar Sara 
Published: August 2022

PurposeIn this article we aim to understand how the network formed by fitness tracking devices and associated apps as a subset of the broader health-related Internet of things is capable of spreading information.Design/methodology/approachThe authors used a combination of a content analysis, network analysis, community detection and simulation. A sample of 922 health-related apps (including manufacturers' apps and developers) were collected through snowball sampling after an initial content analysis from a Google search for fitness tracking devices.FindingsThe network of fitness apps is disassortative with high-degree nodes connecting to low-degree nodes, follow a power-law degree distribution and present with low community structure. Information spreads faster through the network than an artificial small-world network and fastest when nodes with high degree centrality are the seeds.Practical implicationsThis capability to spread information holds implications for both intended and unintended data sharing.Originality/valueThe analysis confirms and supports evidence of widespread mobility of data between fitness and health apps that were initially reported in earlier work and in addition provides evidence for the dynamic diffusion capability of the network based on its structure. The structure of the network enables the duality of the purpose of data sharing.
Challenging the problem of un-democratic participation: from destruction to re-construction of heritage
Authors: Jansson Ina-Maria 
Published: August 2022

PurposeThe present study aims to contribute to the understanding of digital participation in heritage collections as a democratizing practice by identifying and challenging silent assumptions concerning how the insufficient influence of participants is conceived of as a problem.Design/methodology/approachThree carefully selected scholarly texts incorporating problematizations of insufficient participatory agency were analyzed in detail using a method inspired by Carol Bacchi's approach “what's the problem represented to be?” (WPR), with special emphasis on analysis of ontological elements of the problematizations.FindingsParticipation is problematized based on the assumption that participatory agency risks jeopardizing the protection of heritage and leads to parts of the public memory being forgotten. To challenge the idea that participatory agency is destructive, the present article argues for elaborating an understanding of what forgetting entails for heritage. Framing forgetting as a potentially both harmful and generative concept enables a separation of destructive forgetting (e.g. destruction of historical evidence) and constructive forgetting (re-contextualization).Research limitations/implicationsThe study is based on a limited number of texts, and problematizations are investigated in relation to a specific perspective on participatory agency.Practical implicationsBy understanding forgetting as a potentially beneficial activity for representation and heritage construction, the article provides a conceptual rationale for facilitating re-contextualization in the design of multi-layered information structures for heritage collections.Originality/valueThere is little earlier research on the silent assumptions that affect how participation is understood and implemented.