bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pattern of Risk Factors Associated with Pregnancy among the Recently Delivered Women
Authors: Shirin Sharmin , Islam Md Nazrul , Islam Moinul 
Published: November 2022

Background: ‘Pregnancy risk’ is defined as the probability of dying or experiencing severe injury as theresult of pregnancy or childbirth. High maternal mortality rate can be decreased by reduction of pregnancy risk among the women.Objectives: To find out the pattern of pregnancy risk among the recently delivered women.Methods and Material: This cross sectional study was conducted in gynecology and obstetrics department of Dhaka Medical College, Hospital and Combined Military Hospital, Dhaka from January 2004 to July 2004. Semi structured questionnaire was used as data collection instrument. Collected data were analyzed by SPSS.Results: A total number of 124 recently delivered women were studied during this period. The study revealed that most of the respondent 36.3% were 20-24 years of age groups. Most of the respondents 90.3% were housewife, 24.2% were illiterate and 91.1 % received antenatal care. About 31.5% had previous bad obstetric history and 25.8% had morbidity during pregnancy. The frequent compliant was high blood pressure in 37.5%. Among the respondents 45.2% had obstetric problem during recent pregnancy and highest percentage had complaint of dependent oedema is 51.8%. About 60.5% respondents faced problem during delivery and 12.9% had history of complication after delivery. The study revealed that 62.5% of age group <20 and _>_ 35 had 3 risk factors compared to 26.9% of age group 20-35 had 3 risk factors. The proportion of 3 risk factors were higher among the mothers whose husband were day labour (59.1%) compared to service holder (26.3%) and businessman (22.7%). The proportion of >_ 3 risk factors were higher among the mother with history of two abortion (85.7%) as compared to single abortion (51.7%) and no abortion (20.5%). The study revealed that pregnancy risk was statistically significant in relation to age, occupation, education, number of pregnancy and number of abortion among the recently delivered women.
Conclusion: The result of this study would be helpful in making appropriate interventions for pregnancy risk factors reduction in terms of proper anti natal care, safe delivery system and post-natal care.
AKMMC J 2020; 11(2) : 91-96
Peningkatan Hasil Belajar dan Minat Belajar Matematika Melalui Metode Discovery dan Lembar Kerja Peserta Didik Siswa SMPN 38 Batam
Authors: Arianti Zainani , Gusfawati Gusfawati , Siadari Tuti 
Published: November 2022

Pelajaran matematika yang selama ini selalu dianggap sulit dan menakutkan bagi siswa, berdasarkan hal tersebut guru mengupayakan sebuah solusi dengan mengupayakan penggunaan metode penemuan ( discovery) dan LKPD pada proses pembelajaran untuk dapat meningkatjan hasil belajar dan minat belajar siswa. Penelitian ini bertujuan untuk meningkatkan hasil belajar dan minat belajar siswa pada mata pelajaran matematikar. Jenis penelitian ini adalah Penelitian Tindakan kelas dengan Objek penelitian adalah Siswa dan siswi kelas IX-b SMP Negeri 38 Batam. Instrumen penelitian minat menggunakan kuesioner dan untuk hasil belajar menggunakan model tes tulis setelah dilaksanakan pembelajaran dengan menggunakan metode penemuan ( discovery) dan LKPD. Analisis data penelitian dengan menggunakan perhitungan frekuensi dan Chi Square/χ2 dengan SPSS Versi 24. Hasil penelitian menunjukkan pada minat belajar siklus I kategori baik terdapat 19 siswa (47.5%) dan siklus II terdapat 33 siswa (57,5%), artinya terjadi peningkatan sebesar 10%, sedangakan siswa yang kategori sedang 19 siswa ( 47,5% ) berkurang pada siklus II menjadi 5 siswa ( 2,5% ), dengan demikian terdapat peningkatan minat belajar siswa dari sedang menjadi baik. Hasil belajar pada siklus I kategori tuntas terdapat 24 siswa (60%) dengan rerata nilai 72,725% dan siklus II terdapat 33 siswa (82,5%) dengan rerata nilai siswa 77,10 %, terjadi peningkatan 22,5% siswa tuntas. Dari hasil perolehan siklus I dan siklus II terdapat hubungan yang signifikan antara minat belajar dan hasil belajar siswa.
So-mathec media pembelajaran mobile berbasis android studio pada pembelajaran matematika SMP/MTs
Authors: Jayanti Anggreiny , Hartanto Suryo , Husna Asmaul 
Published: November 2022

Perubahan sistem belajar offline menjadi online menjadikan media pembelajaran sulit digunakan, diperlukan upaya pengembangan media pembelajaran yang fleksibel berdasarkan waktu, tempat dan jumlah pengguna. Tujuan penelitian ini adalah untuk mengembangkan media pembelajaran mobile learning berbasis android studio dengan nama So-MathEc yang valid, praktis dan efektif. Jenis penelitian ini adalah Research and Development (RD). Model pengembangan yang digunakan pada penelitian ini adalah model 4D yang terdiri dari 4 tahapan, yaitu define, design, develop dan dessiminate. Subjek penelitian ini adalah dosen Prodi Pendidikan Matematika, guru Matematika SMP/MTs dan peserta didik kelas 9 SMP/MTs. Instrumen penelitian ini menggunakan lembar penilaian ahli untuk uji validitas, lembar respon guru dan peserta didik untuk uji praktikalitas dan post-test untuk uji efektivitas. Seluruh instrumen yang diterapkan pada subjek penelitian, telah dinyatakan valid oleh ahli. Instrument post-test dinyatakan reliabel dengan nilai ICC 0,798. Berdasarkan hasil penelitian, media pembelajran dinyatakan valid oleh pakar dengan skor rata-rata 3,59. Uji praktikalitas diperoleh dari lembar respon guru dan siswa yang menghasilkan derajat pencapaian 97,50% untuk guru, 89,89% untuk peserta didik, dan 93,70%. Rata-rata keseluruhan derajat pencapian pada kategori “sangat praktis” yang berarti bahwa media dapat dikategorikan praktis. Uji efektivitas media berdasarkan hasil post-test peserta didik menunjukkan hasil 90% ketuntasan klasikal dengan kategori efektif. Berdasarkan penelitian dapat disimpulkan bahwa media pembelajaran So-MathEc yang dikembangkan pada penelitian ini dinyatakan valid, efektif dan praktis
Automated mitral valve assessment for transcatheter mitral valve replacement planning
Authors: Lopes Patricia , Van Herck Paul L. , Ooms Joris F. , Van Mieghem Nicolas M. , Wirix-Speetjens Roel , Sijbers Jan , Vander Sloten Jos , Bosmans Johan 
Published: November 2022

Transcatheter mitral valve replacement (TMVR) has emerged as a minimally invasive alternative for treating patients suffering from mitral valve disease. The number of TMVR procedures is expected to rise as devices currently in clinical trials obtain approval for commercialization. Automating the planning of such interventions becomes, therefore, more relevant in an attempt to decrease inter-subject discrepancies and time spent in patient assessment. This study evaluates the performance of an automated method for detection of anatomical landmarks and generation of relevant measurements for device selection and positioning. Cardiac CT scans of 70 patients were collected retrospectively. Fifty scans were used to generate a statistical shape model (SSM) of the left heart chambers at ten different timepoints, whereas the remaining 20 scans were used for validation of the automated method. The clinical measurements resulting from the anatomical landmarks generated automatically were compared against the measurements obtained through the manual indication of the corresponding landmarks by three observers, during systole and diastole. The automatically generated measurements were in close agreement with the user-driven analysis, with intraclass correlation coefficients (ICC) consistently lower for the saddle-shaped (ICCArea = 0.90, ICCPerimeter 2D = 0.95, ICCPerimeter 3D = 0.93, ICCAP-Diameter = 0.71, ICCML-Diameter = 0.90) compared to the D-shaped annulus (ICCArea = 0.94, ICCPerimeter 2D = 0.96, ICCPerimeter 3D = 0.96, ICCAP-Diameter = 0.95, ICCML-Diameter = 0.92). The larger differences observed for the saddle shape suggest that the main discrepancies occur in the aorto-mitral curtain. This is supported by the fact that statistically significant differences are observed between the two annulus configurations for area (p &lt; 0.001), 3D perimeter (p = 0.009) and AP diameter (p &lt; 0.001), whereas errors for 2D perimeter and ML diameter remained almost constant. The mitral valve center deviated in average 2.5 mm from the user-driven position, a value comparable to the inter-observer variability. The present study suggests that accurate mitral valve assessment can be achieved with a fully automated method, what could result in more consistent and shorter pre-interventional planning of TMVR procedures.
Serum level of calpains product as a novel biomarker of acute lung injury following cardiopulmonary bypass
Authors: Yi Chenlong , Chen Fangyu , Ma Rongrong , Fu Zhi , Song Meijuan , Zhang Zhuan , Chen Lingdi , Tang Xing , Lu Peng , Li Ben , Zhang Qingfen , Song Qifeng , Zhu Guangzheng , Wang Wei , Wang Qiang , Wang Xiaowei 
Published: November 2022

ObjectiveThe aim of this study was to test the hypothesis whether serum level of calpains could become a meaningful biomarker for diagnosis of acute lung injury (ALI) in clinical after cardiac surgery using cardiopulmonary bypass (CPB) technology.Methods and resultsSeventy consecutive adults underwent cardiac surgery with CPB were included in this prospective study. Based on the American-European Consensus Criteria (AECC), these patients were divided into ALI (n = 20, 28.57%) and non-ALI (n = 50, 71.43%) groups. Serum level of calpains in terms of calpains’ activity which was expressed as relative fluorescence unit (RFU) per microliter and measured at beginning of CPB (baseline), 1 h during CPB, end of CPB as well as 1, 12, and 24 h after CPB. Difference of serum level of calpains between two groups first appeared at the end of CPB and remained different at subsequent test points. Univariate and multivariate logistic regression analysis indicated that serum level of calpains 1 h after CPB was an independent predictor for postoperative ALI (OR 1.011, 95% CI 1.001, 1.021, p = 0.033) and correlated with a lower PaO2/FiO2 ratio in the first 2 days (The first day: r = -0.389, p &lt; 0.001 and the second day: r = -0.320, p = 0.007) as well as longer mechanical ventilation time (r = 0.440, p &lt; 0.001), intensive care unit (ICU) length of stay (LOS) (r = 0.419, p &lt; 0.001) and hospital LOS (r = 0.297, p = 0.013).ConclusionElevated serum level of calpains correlate with impaired lung function and poor clinical outcomes, indicating serum level of calpains could act as a potential biomarker for postoperative ALI following CPB in adults.Clinical trial registration[https://clinicaltrials.gov/show/NCT05610475], identifier [NCT05610475].
Peptidylarginine deiminase 4 deficiency in bone marrow cells prevents plaque progression without decreasing atherogenic inflammation in apolipoprotein E-knockout mice
Authors: Paunel-Görgülü Adnana , Conforti Andreas , Mierau Natalia , Zierden Mario , Xiong Xiaolin , Wahlers Thorsten 
Published: November 2022

IntroductionDespite multiple studies in the past, the role of peptidylarginine deiminase 4 (PAD4) in atherosclerosis is currently insufficiently understood. In this regard, PAD4 deletion or inhibition of enzymatic activity was previously reported to ameliorate disease progression and inflammation. Besides, strong influence of neutrophil extracellular traps (NETs) on atherosclerosis burden has been proposed. Here, we studied the role of PAD4 for atherogenesis and plaque progression in a mouse model of atherosclerosis.Methods and resultsLethally irradiated ApoE–/– mice were reconstituted with ApoE–/–/Pad4–/– bone marrow cells and fed a high-fat diet (HFD) for 4 and 10 weeks, respectively. PAD4 deficiency did not prevent the development of atherosclerotic lesions after 4 weeks of HFD. However, after 10 weeks of HFD, mice with bone marrow cells-restricted PAD4 deficiency displayed significantly reduced lesion size, impaired lipid incorporation, decreased necrotic core area and less collagen when compared to ApoE–/– bone marrow-transplanted mice as demonstrated by histological staining. Moreover, flow cytometric analysis and quantitative real-time PCR revealed different macrophage subsets in atherosclerotic lesions and higher inflammatory response in these mice, as reflected by increased content of M1-like macrophages and upregulated aortic expression of the pro-inflammatory genes CCL2 and iNOS. Notably, diminished oxLDL uptake by in vitro-polarized M1-like macrophages was evidenced when compared to M2-like cells.ConclusionThese results suggest that pharmacological inhibition of PAD4 may impede lipid accumulation and lesion progression despite no beneficial effects on vascular inflammation.
Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism
Authors: Payer Juraj , Jackuliak Peter , Kužma Martin , Džupon Matúš , Vaňuga Peter 
Published: November 2022

PurposeThe present study aims to evaluate the effect of myo-Inositol plus Selenium supplementation in patients affected by subclinical hypothyroidism.MethodsOne hundred and forty-eight patients were included in the study from 8 different centers of Slovakia, and treated for 6 months with a daily dose of 600 mg myo-Ins plus 83 mcg Se. The patients included at the enrollment were women of reproductive age (18-50), who exhibit values of TSH in the range 2.5-5 mU/l and positivity to antibodies TPO-Ab/TG-Ab, or otherwise values of TSH in the range 5-10 mU/l both with and without positivity to antibodies TPO-Ab/TG-Ab.ResultsPatients affected by subclinical hypothyroidism exhibited a significant improvement of their condition when treated for 6 months with a combination of myo-Inositol and Selenium. The TSH values significantly ameliorated along with the index of autoimmunity and the thyroid status. In a sub-class of patients, the auto-antibody titer decreased after myo-inositol + Selenium administration. The treatment also induces a regularization of the menstrual cycle and a reduction of the cholesterol in the patients enrolled for the study. Furthermore, a significant improvement is observed in the perception of the symptoms associated with subclinical hypothyroidism over the treatment period.ConclusionA dietary supplementation with of myo-Inositol and Selenium in the treatment of patients affected by subclinical hypothyroidism exhibits a beneficial role in the recovery of TSH values, in the improvement of the symptoms associated to this condition and in the maintenance of the thyroid functions.The trial was approved by the Ethical Committee from National Institute of Endocrinology and Diabetology of Lubochna, Slovakia, date 18.12.2018, registration number: 3124/2018.
Short-term effect of different time interval between self-expanding metallic stent and surgery for left-sided malignant colorectal obstruction
Authors: Zhang Jiawei , Su Mingli , Lin Dezheng , Zhong Qinghua , Hu Jiancong , Deng Jiaxin , Lv Miwei , Xu Tian , Li Juan , Guo Xuefeng 
Published: November 2022

BackgroundThe optimal time interval between self-expanding metallic stent (SEMS) placement and surgery in patients with left-sided malignant colorectal obstruction (LMCO) remains controversial. Intestinal obstruction and SEMS placement would lead to intestinal edema, local tumor infiltration, and fibrosis, which may have a certain impact on elective surgery. Although prolong time interval would reduce relative complications, the risk of tumor progression must be taken into account. Therefore, our study proposes whether there is a difference in short-term postoperative complication outcomes between waiting for an interval of ≤4weeks compared with an extended interval for neoadjuvant chemotherapy followed by surgery.MethodsAll patients who underwent SEMS placement as BTS treatment for LMCO between January 2012 and December 2021 were retrospectively identified. The primary outcomes of this study were short-term clinical postoperative complications (Clavien-Dindo grading ≥II).ResultsOf the 148 patients, 70.27% of patients underwent surgery ≤4 weeks of SEMS placement (Group 1) while 29.73% of patients underwent surgery &gt;4 weeks of SEMS placement (Group 2). After SEMS placement, the patients in Group 2 received neoadjuvant chemotherapy and then elective surgery. Significant differences were observed between both groups (Group 2 vs Group 1) for postoperative complications (Clavien-Dindo grading ≥II, 2.3% vs 14.4%, p=0.040), postoperative bowel function time (p&lt;0.001), postoperative hospital stay (p=0.028) and total hospital stay (p=0.002).ConclusionsA bridging interval of &gt;4 weeks between SEMS placement and surgery for LMCO has better short-term clinical outcome.
Holocene sedimentary of the Pearl River Delta in South China: OSL and radiocarbon dating of cores from Zhuhai
Authors: Lin Penghui , Xu Xiaolin , Yan Chaoyang , Luo Lan , Abbas Mahmoud , Lai Zhongping 
Published: November 2022

Deltaic sediments provide a window for investigating delta development processes and the effects of human activities. Despite the fact that numerous studies have been conducted in the Pearl River Delta (PRD), the chronological data are still very limited, which hinder the detailed interpretation of the sedimentary records. The current study aims to establish high-resolution chronology on two cores from Zhuhai using quartz optically stimulated luminescence (OSL) and radiocarbon (14C) dating and, further, to reconstruct the Holocene sedimentary history of the PRD. Core P1-1 has a depth of 79 m and core P3-2 a depth of 60 m. Thirteen quartz OSL samples from P1-1 produced ages between 10.4 and 0.16 ka. Eight OSL and eight 14C ages from P3-2 span from 10.7 to 0.3 ka. The OSL and 14C dates show a good agreement above the depth of 26 m (1.4–0.3 ka), but with discrepancies at depths of 26–54 m. 14C ages (10.7–8.1 ka) are generally older (up to c. 2 ka) than quartz OSL ages, and the discrepancy decreases with depth. The age model shows three phases of the sedimentation process: (1) rapid accumulation rates of 7.48 (P1-1) and 7.52 (P3-2) m/ka between c. 10.7 and 7.5 ka in response to high sea level, (2) followed by a significantly reduced rate of 2.24 m/ka (P1-1) and a depositional hiatus (P3-2) from 7.5 to 2.5 ka as a result of reduced sediment supply and strong scouring by tidal processes, and (3) high sedimentation rates of 8.86 (P1-1) and 9.07 (P3-2) m/ka since 2.5 ka associated with intensive human activities and weakening tidal hydrodynamics. This sedimentary pattern is also evident in many other Asian deltas.
Novel injectable calcium phosphate scaffold with human periodontal ligament stem cell encapsulation in microbeads for bone regeneration
Authors: Qiu Gengtao , Huang Mingguang , Ke Difeng , Liu Jin , Weir Michael D. , Ma Tao , Wang Ping , Oates Thomas W. , Schneider Abraham , Xia Yang , Xu Hockin H. K. , Zhao Liang 
Published: November 2022

Objectives: 1) Develop a novel construct of human periodontal ligament stem cells (hPDLSCs) encapsulated in degradable alginate microbeads (DAMB) with human platelet lysate (hPL) and injectable calcium phosphate cement (ICPC); 2) Investigate the proliferation and osteogenic differentiation of hPDLSCs in ICPC with hPL as a xeno-free supplement and animal serum replacement for bone tissue engineering applications.Methods: hPDLSCs were encapsulated in alginate-fibrin microbeads (DAMB + fibrin), alginate-hPL degradable microbeads (DAMB + hPL), or alginate-fibrin-hPL microbeads (DAMB + fibrin + hPL). The proliferation and osteogenic differentiation of hPDLSCs were investigated in culturing with the ICPC scaffold.Results: Flexural strength of ICPC was 8.4 ± 0.91 MPa, and elastic modulus was 1.56 ± 0.1 GPa, exceeding those of cancellous bone. hPDLSCs had higher viability in DAMB + fibrin + hPL group than in DAMB + fibrin. ALP was 69.97 ± 16.96 mU/mg for ICPC + DAMB + fibrin + hPL group, higher than 30.68 ± 2.86 mU/mg of ICPC + DAMB + fibrin (p &lt; 0.05) and 4.12 ± 1.65 mU/mg of control (p &lt; 0.01). At 7 days, osteogenic gene expressions (ALP, RUNX2, COL1, and OPN) in ICPC + DAMB + fibrin + hPL and ICPC + DAMB + fibrin were 4–11 folds that of control. At 21 days, the hPDLSC-synthesized bone mineral amounts in ICPC + DAMB + fibrin + hPL and ICPC + DAMB + fibrin were 13.2 folds and 11.1 folds that of control group, respectively.Conclusion: The novel injectable CPC scaffold encapsulating hPDLSCs and hPL is promising to protect and deliver hPDLSCs. The hPL-based medium significantly enhanced the osteogenic differentiation of hPDLSCs in ICPC + DAMB + fibrin + hPL construct, suggesting a promising xeno-free approach for bone tissue regeneration applications.
Sleep deprivation and immunoglobulin E level
Authors: Yang Shih-Wei , Yang Hui-Fang , Chen Yuan-Yuei , Chen Wei-Liang 
Published: November 2022

ObjectivesSleep deprivation is a common issue for modern people and leads to many morbidities and mortality. Some papers also suspected the relationship between Immunoglobulin E (IgE) level and sleep deprivation. The purpose of this article is to make the vicious circle between serum IgE level and sleep deprivation clear.Materials and methodsIn this study, we included 4,460 population aged around 48 years old respective 2,145 males and 2,315 females enrolled in the National Health and Nutrition Examination Survey (NHANES). Sleep durations were recorded, in hours, in whole numbers by the participants. The levels of total IgE were measured by anti-IgE. All procedures were analyzed using SPSS version 18 (SPSS, Inc., Chicago, IL, USA).ResultThe statistical significance between higher IgE level and≤5 h sleep duration was noted (Beta coefficients: 64.04, 95% confidence interval (CI): 2.35, 125.72,P= 0.042). In sex difference, the correlation between short sleep duration and high serum IgE levels was noted in male [Beta coefficients: 120.225 (P= 0.008)] but not in female. There were no positive findings in the ethnicity-based correlation between serum IgE levels and sleep duration.ConclusionThis study indicated that short sleep duration (≤5 h) is associated with higher serum IgE levels, especially in men. Further longitudinal investigations concerning the effect of sleep deprivation on serum IgE might provide a better explanation for the pathophysiology underlying autoimmune disease and sleep deprivation.