bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving eating disorder knowledge and attitudes among sports coaches and fitness instructors via the online course “I Care”
Authors: Selenius Sofia , Birgegård Andreas , Mantilla Emma Forsén 
Published: July 2022

Abstract
Background: Fitness instructors, coaches and trainers are often looked up to and seen as role-models within their sporting community. Since problematic exercise is a common symptom of eating disorders, they are also highly likely to meet individuals at risk for developing eating disorders within their profession. Thus, educating coaches about how to promote healthy ideals within their sports/training context and equipping them with knowledge to be able to detect and approach individuals at risk, is of great importance.Method: We studied the pre-to-post effects of the I Care online psychoeducational intervention in 150 coaches, trainers, and fitness instructors. Variables included the Compulsive Exercise Test, as well as knowledge of eating disorders, and confidence and awareness regarding approaching, talking to, and referring individuals whose observed behavior raised concerns.Results: Results showed significant and large improvements in coaches’ confidence and knowledge regarding warning signs and how to approach an at-risk person, and a decrease in their perceived ability to recognize eating disorders by sight, e.g., insight about EDs not being recognizable just by looking at a person. Also, significant positive change in attitudes about their own rule-driven exercise behavior and lack of enjoyment of exercise was observed. Conclusions: Although the lack of a control group compels caution, the study suggests that I Care may have positive effects in terms of a “declaration of intent” toward more positive role-modeling and interactions with clients.
The effect of ZnO addition into TiO2 nano photocatalyst on the degradation of dye compound in aqueous solution under UV-LED irradiation
Authors: Mai Hoang Phuc , Tanabe Shuji , Dao Minh Trung 
Published: July 2022

Abstract
Titanium dioxide (TiO2) is extremely common semiconductor material in a wide use as a photocatalyst for solar conversion as well as in wastewater treatment and environmental air purification. TiO2 catalysts on the other hand, have a narrow band edge (3.2-3 eV for rutile and anatase phases, respectively) that hinders the photocatalytic decomposition. In this regard, the band gap energy has been lowered by attaching various metal oxides to TiO2 catalyst. Both zinc oxide (ZnO) and TiO2 are considered to be semiconductor with a wide band gap, which makes ZnO a potential candidate for combination with TiO2. As a result, the effect of adding ZnO into TiO2 photocatalyst was investigated with regard to the degradation of dye compound in aqueous solution under ultraviolet-light emission diode (UV-LED) irradiation. Powder X-ray diffraction (XRD), scanning electron microscopy [1], and other techniques were utilized in order to characterize the ZnO/TiO2 nanocomposites. Methylene blue (MB) removal was studied using various parameters, including Zn content, catalyst amount, and pH. There was an average crystallite size of 5.7–6.4 nm. When compared to pristine TiO2 nanoparticles, the photolysis of ZnO/TiO2 nanocatalyst was significantly improved. The 1 wt.% ZnO/TiO2 photocatalyst prepared by Al2O3 balls alloying (U1ZnTi) can be applied for direct irradiation under UV-LED light as well as for pollutant adsorption in a short time compared to other studies, suggesting that the U1ZnTi is potential for practical treatment application of organic pollutants as well as dye compounds when a temporary power outage occurs due to unexpected troubles in operation. Photodegradation efficiency of MB by 1 wt.% ZnO/TiO2 (1ZnTi) under UV-LED was greater than that under UV. At an optimal MB decomposition concentration of 40 mg catalyst per gram of ZnO/TiO2 composite, the catalytic activity increased with an increase in ZnO content. At a pH of 7, the most MB was removed without the use of acids or bases.
A high percentage of CD16+ monocytes correlates with the extent of bone erosion in Chronic Lymphocytic Leukemia patients: the impact of leukemic B cells in monocytes differentiation and osteoclasts maturation.
Authors: Giannoni Paolo , Marini Cecilia , Cutrona Giovanna , Todoerti Katia , Neri Antonino , Ibatici Adalberto , Sambuceti Gian Mario , Pigozzi Simona , Mora Marco , Ferrarini Manlio , Fais Franco , Totero Daniela 
Published: July 2022

Abstract
Background
In Chronic Lymphocytic Leukemia (CLL) patients, skeletal alterations are more evident in progressive disease stages. The detection of reactive cells within Bone Marrow (BM), and the evidence of tissue loss in their long bone shafts, suggest that leukemic B cells overgrowth contribute to bone derangement. Indeed, CLL-cells-released-cytokines enhance osteoclasts formation. CD16, a potential marker of monocytes differentiating toward osteoclasts, categorizes three subtypes: “non-classical”, “intermediate” and “classical”. We aimed to clarify whether the expansion of a specific CD16 + population influence bone homeostasis deregulation.
Methods
Cytofluorimetric analysis and patients’ whole body X-ray CT scans were used to evaluate a possible correlation between the expansion of a monocytic subset and the entity of bone erosion. In healthy monocytes, the modulation of CD16, RANK and RANKL expression and the evaluation of osteoclasts differentiation, after CLL-conditioned-media treatment, were assessed by immunofluorescence and Tartrate-resistant alkaline phosphatases (TRAP)/bone-erosion assays, respectively. Osteoclastogenesis was also determined upon M1/M2 polarization or IL-10/TGFβ pre-treatment. Immuno-histochemistry on CLL-BM biopsies was performed to verify simultaneous TRAP/CD16 positivity in osteoclasts in vivo.
Results
Circulating CD16 + monocytes, significantly more abundant in patients than in controls, directly correlated with bone erosion levels. After CLL-cm treatment, CD16 was markedly up-regulated, together with RANK and RANKL, in healthy monocytes. M2-polarized monocytes further resulted CD16 + and showed a striking propensity to differentiate toward osteoclasts. The identification of TRAP+/CD16 + cells, in CLL bone marrow, keeps in line with in vitro data.
Conclusions
Microenvironment/leukemic cells interactions affect bone degradation: specific monocytic subsets (CD16+/M2), notably expanded in these patients, may contribute to this phenomenon.
Shelf life and biochemical changes of chilled Atlantic chub mackerel, Scomber colias, treated with extremophilic microbial films' extracts
Authors: Ibrahim Mohamed , Sabae Soaad , Abo-Zeid Kamel , Abdelkarim Mohamad 
Published: July 2022

Abstract
To get rid of harmful effects of synthetic preservatives and develop new ones from natural sources, extracts of microbial films from extreme habitats of geothermal spring and hypersaline lake in Western Desert, Egypt, were used for chilled Atlantic chub mackerel, Scomber colias, preservations. The aqueous extracts of extremophilic microbial films showed considerable contents of total phenolic and flavonoid contents and good antioxidant activity. The cytotoxicity test of 2% w/v concentrations on normal cells of liver and colon showed very weak effects and the cell viabilities ranged between 95.09 and 98.14%, while the cell viability of carcinoma cells was in the range of 88.74–98.9%. We tested the effect of aqueous extracts of these films on microbial and biochemical characteristics changes of chilled Atlantic chub mackerel. Concentrations of 0.5, 1.0, 1.5 and 2.0% w/v were applied. Total plate count (TPC), pH, value and acid value (AV), total volatile basic nitrogen (TVB-N), trimethylamine nitrogen (TMA-N) content, thiobarbituric acid value (TBA) and free fatty acids (FFA) were investigated for 8 days of storage at 5°C. Principal component analysis (PCA) showed good understanding of the effect of extremophilic microbial films on biochemical features of chilled Atlantic chub mackerel and revealed that the best evaluated TPC and other biochemical characteristics were found at extremophilic microbial levels of 1.0 and 1.5% w/v till the 8th day.
Philadelphia Chromosome-Positive Myelodysplastic Syndrome With Single Lineage Dysplasia
Authors: Kumar Ajeet , Tilak Vijai , Arora Disha , Marisha  , Rahul  , Gautam Deepak , Ali Akhtar 
Published: July 2022

Abstract
Myelodysplastic syndrome (MDS) is a group of acquired clonal disorders characterized by dysplastic and ineffective hematopoiesis in the bone marrow. Various specific karyotypic and molecular abnormalities associated with MDS further guide the prognosis. Although translocation t(9;22)(q34;q11) (Philadelphia positive [Ph+]) and corresponding BCR-ABL fusion transcript are classically defined to differentiate CML from non-CML myeloproliferative disorders, it is also associated with adult acute lymphoblastic leukemia (Ph + ALL), acute myeloid Leukemia (Ph + AML), myelodysplastic syndrome (Ph + MDS). The occurrence of Ph + MDS is very uncommon, and a review of literature has shown by far 40 cases so far in which the majority are seen on progression to Leukemia. Few had de novo presence of such chromosomal abnormality. Due to its rarity, this entity has not yet found its space in the current WHO classification. Also, the role of tyrosine kinase inhibitors in such a scenario is still debatable. We found two such cases of de novo Ph + MDS diagnosed at institute of medical sciences, Banaras Hindu university and a brief literature review.
Clinical Usefulness of Glycated Hemoglobin as a Biomarker of Atherogenic Dyslipidemia
Authors: Yao Chien-An , Yen Tsung-Yi , Su Ta-Chen 
Published: July 2022

Abstract
BACKGROUND: Diabetes mellitus (DM) is a significant health problem and is associated with dyslipidemia; however, the association between glycated hemoglobin (HbA1C) and atherogenic lipids in patients with diabetes and nondiabetes has rarely been reported.METHODS: We prospectively recruited 939 subjects from the Lipid Clinic of the National Taiwan University Hospital. HbA1C and fasting serum lipids, including total cholesterol (TC), high- and low-density lipoprotein cholesterol (HDL-C and LDL-C), small dense LDL-C (sdLDL-C), very low density lipoprotein cholesterol (VLDL-C), triglycerides, and advanced glycation end-products (AGEs), were measured. All subjects except those with diabetes with a fasting period of 10–14 h underwent an oral glucose tolerance test with 75 g of glucose loading. All subjects were asked to discontinue the use of lipid-lowering agents for 4 weeks before study. RESULTS: Patients with DM had a higher prevalence of hypertension, triglyceride, TC/HDL-C ratio, AGEs, VLDL-C and sdLDL-C. Among patients with higher HbA1C levels, the serum levels of triglyceride, VLDL-C, AGEs, and TC/HDL-C ratio were significantly higher than in those groups with lower HbA1C levels. After adjustment for covariates, multiple logistic regression analysis revealed different groups of dysglycemia, such as DM, impaired glucose tolerance (IGT), and normal glucose tolerance (NGT) those with higher HbA1C levels had a higher odds ratio for TC/HDL-C ≥ 5, sdLDL-C ≥75th percentile, VLDL-C ≥ 75th percentile, and AGEs ≥ 75th percentile.CONCLUSIONS: A higher level of HbA1C was associated with a significant increase in the risk of atherogenic dyslipidemia and AGEs levels, and its clinical application is promising.
Hyperthermic intraperitoneal chemotherapy for patients with gastric cancer based on laboratory tests is safe: a single Chinese center analysis
Authors: Wu Yunzi , Zheng Xiaohao , Sun Chunyang , Wang Shenghui , Ding Shikang , Wu Ming , Zhang Jing , Wang Bingzhi , Xue Liyan , Yang Lin , Tian Yantao , Xie Yibin 
Published: July 2022

Abstract
Purpose: This study evaluated the efficacy and safety of hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with gastric cancer diagnosed from laboratory tests. Methods: The clinical and pathological data of 63 patients with gastric cancer who underwent HIPEC in 2017–2021 were prospectively recorded. Fifty-five patients underwent cytoreductive surgery + HIPEC, and eight patients received HIPEC alone. The factors associated with HIPEC safety and efficacy were analyzed. The primary endpoint was overall survival.Results: The average patient age was 54.84 years and 68.3% of patients were male. Moreover, 79.4% of patients had a peritoneal carcinoma index (PCI) score of ≤7 and 61.9% had a completeness of cytoreduction score of 0. Because of peritoneal metastasis, 29 patients (46.03%) were classified as stage IV. Laboratory tests showed no differences in pre-HIPEC blood test results compared to post-HIPEC results after removing the effects of surgery. HIPEC treatment did not cause obvious liver or kidney damage. Serum calcium levels decreased significantly after HIPEC (P=0.0018). The Karnofsky performance status (KPS) score correlated with the patient’s physical function and improved after HIPEC (P=0.0045). In coagulation tests, FDP (P<0.0001) and D-dimer (P<0.0001) levels increased significantly and CA242 (P=0.0159), CA724 (P<0.0001), and CEA (P<0.0014) levels decreased significantly after HIPEC. Completeness of cytoreduction score was an independent prognostic factor. HIPEC did not show a survival benefit in patients with gastric cancer (P=0.5505).Conclusion: HIPEC is a safe treatment for patients with gastric cancer with peritoneal metastasis based on the laboratory tests. Its efficacy in terms of overall survival requires confirmation.
Re-examining of cotton bleaching process conditions with sodium chlorite and phosphonic acid catalysis, and the correction of misunderstandings
Authors: Dursun Sami , Yıldız Salih Zeki 
Published: July 2022

Abstract
Today's environmental and living conditions necessitate reconsideration of traditional cotton fabric bleaching processes. For this reason, it is very important for the environment and economy to obtain higher whiteness values by using less water and chemicals in bleaching. Sodium chlorite (NaClO2), source of chlorine dioxide (ClO2) as the most important disinfectant, which rises the popularity and availability during the Covid-19 pandemic recently is an appropriate oxidant for the purpose. Using NaClO2 as bleaching agent has significant advantages, such as reducing of washing proses and increasing of cotton strength. Another advantage of this reagent is that it causes less fabric weight loss than other reagents. Therefore, the present work was intended to improve the process conditions (different temperatures, concentration, and times) of bleaching of cotton fabric by using NaClO2. Optimum temperature and time were determined as 30 min at 65°C and 30 min at 85°C, and a high whiteness index (W.I.=88) was obtained by using phosphonic acid (HEDP). Moreover, the tensile strength and weight losses and morphologies of the samples were examined. It has been observed that sodium chloride causes little damage to cotton fibers and requires less water for rinsing since it does not form alkaline residues.
An acid-triggered reactive and enhanced fluorescent probe for selective detection of Al3+/H+and its application in real water samples and living cells
Authors: Li Zhigang , Zhao Bing , Kan Wei , Bu Fanqiang , Qi Xin , Wang Liyan , Song Bo , Ding Liming 
Published: July 2022

Abstract
A reactive fluorescent “turn-on” probe (di-PIP) with imine-linked dual phenanthro[9,10-d]imidazole luminophore have been conveniently prepared as an Al3+ and H+ dual functional receptor. di-PIP displayed high selectivity and sensitivity towards Al3+ ion in DMF/HEPES accompanied by fluorescence blue-shift and a good linear relationship as well as a low detection limit of 30.5 nmol·L− 1, which can root from the synergetic functions of the decomposition reaction of di-PIP promoted by acidic Al3+ and the coordination effect between decomposition product and Al3+. Intriguingly, it was found that hydrogen ion H+ can be sufficient for simulating the fluorescence enhancing of di-PIP. 1H NMR titration and MS analyses for elucidation of the intermediate structure further revealed that the acid-triggered decomposition reaction resulted in the rapid, and sensitive sensing to Al3+ and H+. In addition, the probe di-PIP could be successfully applied to the detection of Al3+ in real water samples, and also utilized to visualize Al3+ and H+ in the living cells.
Food-grade titanium dioxide translocates across the oral mucosa in pigs and induces genotoxicity in an in vitro model of human oral epithelium
Authors: Vignard J , Pettes-Duler A , Gaultier E , Cartier C , Weingarten L , Biesemeier A , Taubitz T , Pinton P , Bebeacua C , Devoille L , Dupuy J , Boutet-Robinet E , Feltin N , Oswald IP , Pierre FHF , Lamas B , Mirey G , Houdeau E 
Published: July 2022

Abstract
Background
Food-grade titanium dioxide (TiO2), composed of nano- and submicron-sized particles, is used worldwide in various foodstuffs, toothpastes and pharmaceutical tablets as a whitening and opacifying agent. Its use as a food additive (E171 in EU) has raised concerns for human health regarding its systemic availability, tissue accumulation, genotoxicity and promotion of precancerous lesions. However, although the buccal mucosa is the first area exposed, oral transmucosal passage of TiO2 particles has not been documented. Here we analyzed TiO2 (E171) particle translocation in vivo through the pig buccal mucosa and in vitro on human buccal TR146 cells, and the effects of E171 on proliferating and differentiated human oral epithelial cells.
Results
Using transmission electronic microscopy (TEM) coupled to energy-dispersive X-ray spectroscopy (EDX), isolated TiO2 particles and small aggregates were observed in the buccal floor of pigs starting 30 min after the sublingual deposition of E171 suspended in water, and recovered in the submandibular lymph nodes at 4 h. In human TR146 cells exposed to E171, kinetic analyses using confocal microscopy, TEM and high-resolution secondary ion mass spectrometry (SIMS) imaging showed high uptake capacities of both the nano- and submicron-sized TiO2 particles. At 2 h, the cytotoxicity, genotoxicity and oxidative stress were investigated in both proliferating and differentiated TR146 cells exposed to E171 in comparison with two TiO2 size standards of 115 and 21 nm in diameter. All TiO2 samples were reported cytotoxic in proliferating cells, an effect almost abolished following differentiation. Genotoxicity (γH2AX or 53BP1 foci formation and comet assays) and oxidative stress (CellRox reagent) were only reported for the E171 and 115 nm TiO2 particles, and mainly in proliferating cells.
Conclusions
These data showed that the buccal mucosa is an important absorption route for the systemic passage of food-grade TiO2 particles. In human cells, TiO2 particles are cytotoxic and generate size-dependent oxidative and genotoxic stresses in proliferating cells, potentially impairing oral epithelium renewal. Altogether, these data emphasize that buccal exposure should be considered during toxicokinetic studies and for risk assessment of TiO2 in human when used as food additive, including in toothpastes and pharmaceutical formulations.
OVI-3: A NoSQL visual query system supporting efficient anti-joins
Authors: El-Mahgary Sami , Soisalon-Soininen Eljas , Orponen Pekka , Rönnholm Petri , Hyyppä Hannu 
Published: July 2022

Abstract
The aim of this work was to develop a technique to speed up complexjoins in an incrementally based visual query system or VQS.When designing a visual, highly interactive interface for ad-hoc (readonly)queries, fast response times are of paramount importance. Whilea column-oriented DBMS reduces the inherent latency found in relationalDBMS, there is still the question as how to index the data,especially with regard to complex joins. Equi-joins that involve amany-to-many (M:N) relationship are an example of complex joinsthat arise often and their efficient processing is essential for fastquery processing. For brevity, we refer to such joins as M:N joins.We present OVI-3, a NoSQL visual query system (VQS) basedon incremental querying that uses a simple directory-based indexingscheme for fast M:N joins. OVI-3 acted as a testbed using realdata from the student database at Aalto University. The resultsshowed that the presented indexing scheme for M:N joins can outperformSQL queries from a data server, especially for queries involvinganti-joins (negation), where OVI-3 was orders of magnitude faster.
LncRNA PEG11as Aggravates Cerebral Ischemia/Reperfusion Injury After Ischemic Stroke Through miR-342-5p /PFN1 Axis
Authors: Yu Zhijun , Zhu Ming , Shu Dan , Zhang Rong , Xiang Zifei , Jiang Aihua , Zhang Chunxiang , Yuan Qiong , Hu Xiamin 
Published: July 2022

Abstract
LncRNAs are highly expressed in the CNS and regulate physiological and pathophysiological processes. However, the potential role of lncRNAs in cerebral ischemia/reperfusion (I/R) injury, a common pathological process after ischemic stroke (IS) remains widely unknown. From a RNA-Seq analysis, 254 lncRNAs were identified to be differentially expressed in ischemic/reperfusion (I/R) mice brain tissue, including 234 upregulated and 5 downregulated lncRNAs. Among the 9 lncRNA used for verification, lncRNA paternal expressed gene 11 antisense (PEG11as) was significantly upregulated in the ischemic brain tissues of transient middle cerebral artery occlusion (MCAO) mice and N2a cells from oxygen-glucose deprivation/reoxygenation (OGD/R). Downregulate of PEG11as could markedly attenuate the brain infarct volume, alleviate neurological deficit in vivo, and effectively promote neuron survival, attenuate neuronal apoptosis and caspase 3 activity both in vivo and in vitro. FISH assay discovered that PEG11as was mainly located in the cytoplasm, indicating that PEG11as could be used as a competitive endogenous RNA (ceRNA) to participate in post-transcriptional regulation. Furthermore, we demonstrate PEG11as was able to sponge miR-342-5p to inhibit miR-342-5p activity, resulting in profilin 1 (PFN1) overexpression and subsequently promoting apoptosis. Therefore, this study explored the role and underlying mechanisms of PEG11as in cerebral I/R-induced neuronal damage. It might contribute to the understand of the pathogenesis and provide a potential therapeutic option for the cerebral I/R.
Interpolation by hybrid Radial Basis Functions for solving nonlinear Volterra-Fredholm-Hammerstein integral equations
Authors: Zeghdane Rebiha 
Published: July 2022

Abstract
Interpolation by radial basis functions technique have grown significantly in recent years due to their ability for solving several problems almost impossible to obtain with standard methods. In this paper, an efficient scheme is given to solve nonlinear one-dimensional Fredholm-Volterra-Hammerstein integral equations, this technique is based on hybrid radial basis functions including the multiquadric, the Gaussian and cubic radial basis functions (RBFs). All integrals appeared in the scheme are approximately computed by the Gauss–Legendre integration formula. The new technique can be used for higher dimensional integral equations and does not increase difficulties in computation due to the easy adaption of radial basis functions. The convergence analysis and the accuracy of the proposed approach are given. Numerical examples clearly show the reliability and efficiency of the method.2000-Mathematics subject classification: 65XX, 65Dxx, 65D12.