bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance analysis of 6LoWPAN protocol for a flood monitoring system
Authors: Gabriel Piñeres-Espitia , Butt Shariq Aziz , Francisco Estévez-Ortiz , Alejandro Cama-Pinto , Maleh Yassine 
Published: March 2022

AbstractThe internet of things is a disruptive technology that has been applied as a solution to problems in many fields of monitoring environmental variables. It is supported by technologies such as wireless sensor networks, which offer many protocols and hardware platforms in the market today. Protocols such as 6LoWPAN are novel, so this work focuses on determining whether its implementation on TelosB mote is feasible; these would be placed on an experimental deployment for a particular scenario of flash floods in a sector known as “La Brigada”, in the city of Barranquilla. This proposal has not been evaluated in Colombia for this type of application, and no similar work has been done for this type of scenario. For the evaluation of 6LoWPAN, a deployment with two end nodes and a sink node has been designed, due to the monitoring section under study; 5-min tests are proposed where through round trip time traffic PINGv6 packets are generated back and forth (Echo) between a sink node and two end nodes. The results are based on the evaluation of metrics such as delay and ping packet request/response rate. The performance of these metrics is subject to test scenarios that vary according to distance, packet size, and channel scan time. Two routing options, static or dynamic, are also proposed for this application case. The tests performed yielded results in terms of better performance in the test scenarios for packets with an average size of 120 B and channel monitoring times of 1024 ms. Likewise, the use of the TelosB platform was validated as a viable and innovative option for a monitoring scenario to flash floods in short stretches of the city of Barranquilla—Colombia. This study is important because it can provide information on the use of the TelosB platform as a valid solution for similar application scenarios; furthermore, the tests performed can be replicated in similar studies to evaluate congestion, power consumption, routing, topologies, and other metrics. This study is providing a road map for the research community to follow the simulation scenario to apply the test to their own studies. This work also provides the guidelines for similar researchers to monitor the flood in their own regions and then compare their results with this study.
Hyers–Ulam stability and hyperstability of a Jensen-type functional equation on 2-Banach spaces
Authors: Selvan Arumugam Ponmana , Najati Abbas 
Published: March 2022

AbstractThe main aim of this paper is to establish the Hyers–Ulam stability and hyperstability of a Jensen-type quadratic mapping in 2-Banach spaces. That is, we prove the various types of Hyers–Ulam stability and hyperstability of the Jensen-type quadratic functional equation of the form $$ g \biggl( \frac{x+y}{2} + z \biggr) + g \biggl( \frac{x+y}{2} - z \biggr) + g \biggl( \frac{x-y}{2} + z \biggr) + g \biggl( \frac{x-y}{2} - z \biggr) = g(x) + g(y) + 4 g(z), $$
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in 2-Banach spaces by using the Hyers direct method.
Regularity and uniqueness for the 3D compressible magnetohydrodynamic equations
Authors: Zhang Mingyu 
Published: March 2022

AbstractIn this paper, some new $L^{p}$

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gradient estimates are justified for the three-dimensional compressible magnetohydrodynamic equations in the whole space $\mathbb{R}^{3}$

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is the “div-curl” decomposition technique. For regular initial data with small energy, we prove the existence of global solutions belonging to a new class of functions in which the uniqueness can be shown to hold.
Nutrition-sensitive chicken production in Ethiopia: a qualitative evaluation
Authors: Passarelli Simone , Abdelmenan Semira , Tewahido Dagmawit , Demmu Yohannes Mulugeta , Abreham Helen , Ambikapathi Ramya , Gunaratna Nilupa S. , Berhane Yemane , Fawzi Wafaie 
Published: March 2022

AbstractSmall-scale chicken production holds great potential as a nutrition-sensitive strategy in low-income settings, due to its potential for improving income, increasing the consumption of nutritious foods (including eggs and meat), and empowering women. This study sought to evaluate the impacts of and to identify challenges and solutions for a nutrition-sensitive chicken production intervention in rural Ethiopia. We conducted a qualitative study following the endline evaluation of the African Chicken Genetic Gains and Agriculture to Nutrition project in the Amhara and Oromia regions of Ethiopia. Using semi-structured interviews, we held twelve Focus Group Discussions with woman project participants and six Key Informant Interviews with project staff. Data were analyzed using thematic analysis. Six Focus Group Discussions were with participants in the African Chicken Genetic Gains intervention, through which women received 25 high-yielding chickens. The other six Focus Group Discussions were held with participants who (in addition to the African Chicken Genetic Gains intervention) also received the Agriculture to Nutrition intervention, which focused on nutrition-sensitive behavior change communication related to child feeding, water, sanitation and hygiene, and home gardening. The African Chicken Genetic Gains and the Agriculture to Nutrition interventions benefited participants through improved income, nutrition, and child caregiving knowledge. Nutrition and child feeding benefits were emphasized more in the nutrition-sensitive behavior change arm, while income benefits were emphasized more in the arm that did not receive behavior change. The primary challenges of the project included death and disease of chickens and implementation issues at both the project and household levels. Recommendations to address these challenges included improved chicken housing designs, access to inputs, access to veterinary care (including vaccines and medication), and project logistics. The nutrition-sensitive and chicken production interventions were largely well-received by participants. Most participants agreed that the benefits of the project outweighed the challenges. Future projects would benefit from logistical and infrastructural improvements to improve implementation and impacts on nutrition, health, and livelihoods.
Global DNA methylation profiling reveals chromosomal instability in IDH-mutant astrocytomas
Authors: Liu Yan , Sathe Adwait Amod , Abdullah Kalil G. , McBrayer Samuel K. , Adams Steven H. , Brenner Andrew J. , Hatanpaa Kimmo J. , Viapiano Mariano S. , Xing Chao , Walker Jamie M. , Richardson Timothy E. 
Published: March 2022

AbstractDiffusely infiltrating gliomas are among the most common central nervous system tumors in adults. Over the past decade, the subcategorization of these tumors has changed to include both traditional histologic features and more recently identified molecular factors. However, one molecular feature that has yet to be integrated is the presence/absence of chromosomal instability (CIN). Herein, we use global methylation profiling to evaluate a reference cohort of IDH-mutant astrocytomas with and without prior evidence of CIN (n = 42), and apply the resulting methylation-based characteristics to a larger test cohort of publicly-available IDH-mutant astrocytomas (n = 245). We demonstrate that IDH-mutant astrocytomas with evidence of CIN cluster separately from their chromosomally-stable counterparts. CIN cases were associated with higher initial histologic grade, altered expression patterns of genes related to CIN in other cancers, elevated initial total copy number burden, and significantly worse progression-free and overall survival. In addition, in a grade-for-grade analysis, patients with CIN-positive WHO grade 2 and 3 tumors had significantly worse survival. These results suggest that global methylation profiling can be used to discriminate between chromosomally stable and unstable IDH-mutant astrocytomas, and may therefore provide a reliable and cost-effective method for identifying gliomas with chromosomal instability and resultant poor clinical outcome.
Diabetes emergency cases identification based on a statistical predictive model
Authors: Azbeg Kebira , Boudhane Mohcine , Ouchetto Ouail , Jai Andaloussi Said 
Published: March 2022

AbstractDiabetes is a chronic metabolic disease which is characterized by a permanently high blood sugar level. A distinction is made between two forms: Type 1 diabetes and Type 2 diabetes. It is believed that there are around 415 million people between the ages of 20 and 79 worldwide who have some form of diabetes illness today. In Europe, over 60 million people are diabetic, a diabetes incidence of 10.3% of men and 9.6% of women is estimated. The prevalence of diabetes is increasing among all ages in the European Region, mainly due to increases in overweight and obesity, unhealthy diet, and physical inactivity. A huge people in this population have type 2 diabetes, and the numbers will continue to rise over the next few years. So one can speak of a real widespread disease. The problem is not only the increased blood sugar, but also complications and accompanying diseases such as heart attack, stroke, or diabetic foot. However, as a type 2 diabetic, we can significantly influence the course of the disease and the success of therapy. To do this, it is important that we early detect the person that have (or likely have) a serious problem or an emergent case, and know about it as fast as possible. Early detection and treatment of this disease are very important to help diabetics live a healthy and near normal life. It can also help to avoid several serious complications. In addition, the evolution of wearable and Internet of Things medical devices can help to collect various health data for diagnosis using machine learning algorithms. In this paper, we present an IoT-based system architecture which ensures the collection of patient data in order to predict serious cases of diabetes. To secure data, Blockchain and IPFS are used, and to analyze data, we propose a statistical-based method for predictions. The process is as follows. First, data were collected from IoT devices, and a dataset was constructed and stored using IPFS. Then, the data will be scaled and filtered using noise-invariant data expansion. Next, an adaptive random forest algorithm is made in order to train data on the training dataset, and people with diabetes were classified using the proposed model. Three datasets were used, namely, the Pima Indian diabetes dataset, the Frankfurt Hospital diabetes dataset, and the last is the fusion of these two datasets. Finally, the performance of the method was evaluated and compared with other recent prediction methods. Based on the experiment result, an accuracy of 85.9%, 99.5%, and 99.8% has been achieved based on the three datasets, respectively. Thus, the model can be used to predict and alert physicians or hospitals serious cases that need urgent reactions.
Recombinant human soluble thrombomodulin for acute exacerbation of idiopathic pulmonary fibrosis: a nationwide observational study
Authors: Awano Nobuyasu , Jo Taisuke , Izumo Takehiro , Inomata Minoru , Morita Kojiro , Matsui Hiroki , Fushimi Kiyohide , Urushiyama Hirokazu , Nagase Takahide , Yasunaga Hideo 
Published: March 2022

Abstract
Background
Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is the leading cause of death among patients with IPF. However, there is no established treatment for this condition. Hence, we aimed to investigate the effectiveness and safety of recombinant human soluble thrombomodulin (rTM) for the treatment of AE-IPF.

Methods
Data were retrospectively collected from the Japanese Diagnosis Procedure Combination database from 1 January 2014 to 31 March 2018. We identified adult patients with IPF who received high-dose methylprednisolone (mPSL) therapy and mechanical ventilation upon admission. Eligible patients (n = 2814) were divided into those receiving high-dose mPSL alone (mPSL alone group, n = 2602) and rTM combined with high-dose mPSL (rTM group, n = 212). A stabilised inverse probability of treatment weighting (IPTW) using propensity scores was performed to compare outcomes between the two groups. The primary outcome was in-hospital mortality, and the secondary outcomes were 14- and 28-day mortality, bleeding events and length of hospital stay.

Results
The in-hospital mortality rates of the mPSL alone and rTM groups were 75.9% and 76.9%, respectively. The results did not significantly differ between the two groups after performing a stabilised IPTW. The odds ratio of the rTM group compared to the mPSL alone group was 1.15 (95% confidence interval: 0.71–1.84; p = 0.57). Moreover, the secondary outcomes did not differ significantly between the two groups.

Conclusions
In patients with AE-IPF who developed severe respiratory failure, rTM in addition to high-dose mPSL was not associated with a better outcome.
Hypnotherapy for procedural pain, itch, and state anxiety in children with acute burns: a feasibility and acceptability study protocol
Authors: Geagea Dali , Griffin Bronwyn , Kimble Roy , Polito Vince , Terhune Devin B. , Tyack Zephanie 
Published: March 2022

Abstract
Background
Burns and related procedures are painful and distressing for children, exposing them to acute and chronic sequelae that can negatively affect their physiological, psychological, and social functions. Non-pharmacological interventions such as distraction techniques are beneficial adjuncts to pharmacological agents for procedural pain, state anxiety, and itch in children with burns but have limitations (e.g. lack of research on burn-related itch, tailoring, and consensus on optimal treatment). Hypnotherapy is a non-pharmacological intervention that can be tailored for varied settings and populations with evidence of benefit for itch and superior effectiveness in comparison to other non-pharmacological interventions for children’s procedural pain and state anxiety. Thus, children with burns can benefit from hypnotherapy as an adjunct to pharmacological agents. Yet, in paediatric burns, rigorous studies of effectiveness are limited and no studies have been identified that screen for hypnotic suggestibility, an important predictor of hypnotherapy outcomes. Considering potential barriers to the delivery of hypnotherapy in paediatric burns, the proposed study will examine the feasibility and acceptability of hypnotic suggestibility screening followed by hypnotherapy for procedural pain, state anxiety, and itch in children with acute burns.

Methods
An observational mixed-methods feasibility and acceptability study will be conducted over 15 weeks. Eligible children (N = 30) aged 4 to 16 years presenting to a paediatric burns outpatient centre in a metropolitan children’s hospital in Australia with acute burns requiring dressing changes will be included. Eligible parents of children (N = up to 30) and clinicians who perform dressing changes (N = up to 20) will also be included. Child participants screened as having medium to high suggestibility as assessed by behavioural measures will receive hypnotherapy during dressing changes. A process evaluation will target feasibility and acceptability as primary outcomes and implementation (i.e. fidelity in delivery), reach, potential effectiveness, and adoption of evaluation procedures and intervention as secondary outcomes.

Discussion
Ethical approval was obtained from the Queensland Children’s Hospital and Health Service ethics committee. Results will be published in peer-reviewed publications and conference proceedings.
The findings will guide the design of future trials on the effectiveness of hypnotherapy and inform the development of child-centred hypnotic interventions in children with burns.

Trial registration
Australian New Zealand Clinical Trials Registry ACTRN12620000988954
A study of the genotyping and vascular endothelial growth factor polymorphism differences in diabetic and diabetic retinopathy patients
Authors: Wagih Sara , Hussein Manal M. , Rizk Kareem A. , Abdel Azeem Amira A. , El-Habit Ola H. 
Published: March 2022

AbstractBackgroundRetinopathy is one of the major causes of visual impairment which is the most severe microvascular complication of diabetes mellitus (DM). The aim of this study was to evaluate the association between diabetic retinopathy (DR) and two SNPs (− 152G > A and − 165C > T) located in the promoter region of the vascular endothelial growth factor (VEGF) gene in a small sample from Egyptian population. One hundred diabetic patients without retinopathy (DWR) and two hundred diabetic patients with retinopathy were included in this study. Genotype analysis for the two SNPs (− 152G > A and − 165C > T) was assessed by using the PCR–RFLP technique. In addition, the serum protein level of VEGF was measured by ELISA assay.ResultsThe results showed a significant relationship between − 152G > A (rs13207351) polymorphism and both proliferative and non-proliferative retinopathy in genotypes (GG, GA, AA). The risk factor increment in the mutant heterozygous genotype (GA) was significantly increased in NPDR compared to PDR (OR = 16.3, 95%CI = 0.80–331.7); (OR = 20.4, 95%CI = 1.08–385.3), respectively. There was no significance between VEGF − 165C > T (rs79469752) gene polymorphism and retinopathy. Moreover, the serum protein level of VEGF showed a highly significant increase (P = 0.0001) in PDR (Mean ± SD = 3691 ± 124.9) when compared to both DWR (Mean ± SD = 497.3 ± 18.51) and NPDR (Mean ± SD = 1674.5 ± 771.7). These results were supported by the increased level of VEGF in serum protein which is positively correlated with the severity of retinopathy. Measuring VEGF protein level in DR patients would help as a biomarker in early diagnosis.ConclusionThe increase in the mutant heterogeneous GA genotype in VEGF − 152G > A SNP could be a risk factor for the progression of severe retinopathy in diabetic patients.
Treatment options for entrapment neuropathy of infrapatellar branch of saphenous nerve post knee arthroplasty: a case report
Authors: Singh Tejinder , Kumar Parijat 
Published: March 2022

Abstract
Background
The infrapatellar branch of the saphenous nerve is highly prone to form a neuroma or undergo transaction after midline incision of knee arthroplasty. The presence of neuroma and entrapment of these fibers can cause pain and numbness/tingling in the knee. The presence of these symptoms can significantly impact rehabilitation outcomes and long-term outcomes.

Case presentation
The patient is a 63-year-old Caucasian female reported to an outpatient orthopedic physical therapy clinic post left knee arthroplasty. The patient reported severe pain (VAS-9/10) with knee range of motion from 5 to 64° flexion. The lower extremity functional score was 42/80 with moderate deficits in function.

Conclusion
The anterior inferior knee pain with saphenous nerve entrapment can cause severe symptoms. Soft tissue mobilizations followed by neurodynamic techniques can improve neural mobility and functional outcomes (LEFS-52/80).
Multicenter, Randomized, Phase III Trial of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy in Locally Advanced Rectal Cancer (STELLAR)
Authors: Jin Jing , Tang Yuan , Hu Chen , Jiang Li-Ming , Jiang Jun , Li Ning , Liu Wen-Yang , Chen Si-Lin , Li Shuai , Lu Ning-Ning , Cai Yong , Li Yong-Heng , Zhu Yuan , Cheng Guang-Hui , Zhang Hong-Yan , Wang Xin , Zhu Su-Yu , Wang Jun , Li Gao-Feng , Yang Jia-Lin , Zhang Kuan , Chi Yihebali , Yang Lin , Zhou Hai-Tao , Zhou Ai-Ping , Zou Shuang-Mei , Fang Hui , Wang Shu-Lian , Zhang Hai-Zeng , Wang Xi-Shan , Wei Li-Chun , Wang Wen-Ling , Liu Shi-Xin , Gao Yuan-Hong , Li Ye-Xiong 
Published: March 2022

PURPOSE To ascertain if preoperative short-term radiotherapy followed by chemotherapy is not inferior to a standard schedule of long-term chemoradiotherapy in patients with locally advanced rectal cancer. MATERIALS AND METHODS Patients with distal or middle-third, clinical primary tumor stage 3-4 and/or regional lymph node–positive rectal cancer were randomly assigned (1:1) to short-term radiotherapy (25 Gy in five fractions over 1 week) followed by four cycles of chemotherapy (total neoadjuvant therapy [TNT]) or chemoradiotherapy (50 Gy in 25 fractions over 5 weeks, concurrently with capecitabine [chemoradiotherapy; CRT]). Total mesorectal excision was undertaken 6-8 weeks after preoperative treatment, with two additional cycles of CAPOX (intravenous oxaliplatin [130 mg/m2, once a day] on day 1 and capecitabine [1,000 mg/m2, twice a day] from days 1 to 14) in the TNT group and six cycles of CAPOX in the CRT group. The primary end point was 3-year disease-free survival (DFS). RESULTS Between August 2015 and August 2018, a total of 599 patients were randomly assigned to receive TNT (n = 302) or CRT (n = 297). At a median follow-up of 35.0 months, 3-year DFS was 64.5% and 62.3% in TNT and CRT groups, respectively (hazard ratio, 0.883; one-sided 95% CI, not applicable to 1.11; P < .001 for noninferiority). There was no significant difference in metastasis-free survival or locoregional recurrence, but the TNT group had better 3-year overall survival than the CRT group (86.5% v 75.1%; P = .033). Treatment effects on DFS and overall survival were similar regardless of prognostic factors. The prevalence of acute grade III-V toxicities during preoperative treatment was 26.5% in the TNT group versus 12.6% in the CRT group ( P < .001). CONCLUSION Short-term radiotherapy with preoperative chemotherapy followed by surgery was efficacious with acceptable toxicity and could be used as an alternative to CRT for locally advanced rectal cancer.