bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-related Quality of Life and Direct Healthcare Costs of X-linked Hypophosphatemia in Spain
Authors: Yanes Maria Isabel Luis , Díaz-Curiel Manuel , Peris Pilar , Vicente Carmen , Marín Silvia , Ramon-Krauel Marta , Hernández Julio , Broseta José Jesús , Espinosa Laura , Mendizábal Santiago , Pérez-Sukia Leyre , Martínez Victor , Palazón Cristina , Piñero Juan Antonio , Calleja Miguel Ángel , Espín Jaime , Arboiro-Pinel Rosa María , Ariceta Gema 
Published: March 2022

Abstract
BackgroundThe purpose of this study is to analyze the health-related quality of life (HRQoL) of pediatric and adult patients with X-linked hypophosphatemia (XLH) treated with conventional therapy, as well as to assess the direct healthcare costs of the disease.We used several versions of the EuroQol-5 dimensions (EQ-5D) instrument according to the age of patients with XLH. Then we compared the HRQoL of patients to that of general Spanish population.We estimated direct healthcare costs by means of expert knowledge, consultation with hospital accounting departments, public databases and literature review.Results Children with XLH (n = 21) had moderate problems in walking about (61.9%), washing or dressing themselves (9.52%), and performing their usual activities (33.33%). They also felt moderate pain or discomfort (61.9%) and were moderately anxious or depressed (23.81%).Adults with XLH (n = 29) had lower HRQoL, with problems in walking (93%, with 3.45% unable to walk independently), some level of pain (86%, with 3.45% experiencing extreme pain), problems with their usual activities (80%) and self-care (>50%), and reported symptoms of anxiety and/or depression (65%). There were important differences with the general Spanish population.Regarding costs, XLH was associated with important direct healthcare costs to the national healthcare system, accounting for more than 5 million euros per year. However, the socioeconomic cost of XLH is considerably higher than that.ConclusionsXLH impacts negatively on physical functioning and HRQoL of patients, which increases both direct and indirect costs associated with XLH. In Spanish patients with XLH, the HRQoL was reduced despite conventional treatment and associated healthcare costs were high, clearly indicating the need to improve the therapeutic approach of this disorder.
Transgenerational effects of pest management strategy on fluctuating asymmetry in the European earwig Forficula auricularia: Being the progeny of a mother who lived in conventional orchards makes you more asymmetric than having a mother who lived in insecticide free orchards.
Authors: Moiroux Joffrey , Koné Doufoungognon C. , Navenant Adrien Le , Suchail Séverine , Rault Magali 
Published: March 2022

Abstract
Fluctuating asymmetry (FA), defined as the random non-directional deviation from perfect bilateral symmetry, is considered to reflect developmental instability in bilaterally symmetrical organisms. It has been commonly used as a reliable biomarker of environmental stresses in natural populations. In agroecosystems, FA may arise through transgenerational influence of insecticides. We measured fluctuating asymmetry on unexposed progeny of Forficula auricularia mothers sampled in orchards that used no to frequent insecticides’ applications. Seven morphometric traits were measured on both right and left side and fluctuating asymmetry was calculated. Among these seven traits, four were more asymmetric when the progeny was born from a mother who lived in conventional orchards that used insecticides frequently compared to a mother who lived in insecticide free orchards. Males were more asymmetric than females for all traits but pest management strategy influenced FA in a similar way for both sexes. Measuring FA on unexposed daughters and sons of individuals originating from natural ecosystems may thus be a reliable easy-to-use tool to monitor mid-term effects of insecticides in the environment.
Energy Efficient Congestion Free And Adaptive Mechanism For Data Delivery In Underwater Wireless Sensor Networks Using 2H-ACK
Authors: Baskar M. , Anbarasu V. , Balaji A. , Kalyanasundaram P. , Thiagarajan R. , Arulananth T.S. 
Published: March 2022

Abstract
Underwater Wireless Sensor Networks (UWSN) seems to be significant area of research as it gives out proper answer for monitoring uneven circumstances that may result and bring forth scare in human existence. The challenging process in UWSN, they have large amount of delay, easily error prone, low availability of bandwidth and high congestions control. In this paper, we propose a mechanism that addresses the reliability of the network by adapting two hop acknowledgement (2H-ACK) models. Enhancement of the model is carried out to make it energy efficient congestion free by integrating the hybrid approach into the existing protocols. By this enhanced model, it shows that the performance of the model is good when compared to the existing ones. Simulation outcomes prove that the 2H-ACK proves to be best in delivery ratio when checked with existing hop by hop acknowledgement.
The Association Of Hypertriglyceridemic Waist Phenotype With Uric Acid: A Cross-Sectional Study In A Chinese Population
Authors: Xuan Yan , Gu Xi , Shen Ying , Wang Sujie , Gao Ping , Tang Dou , Wang Xun , Zhu Fanfan , Lu Leiqun , Chen Ling 
Published: March 2022

Abstract
Background: The aim of this study was to research the association between the hypertriglyceridemic-waist (HTGW) phenotype and uric acid in a large general population.Methods: A total of 9015 participants from the cross-sectional study were enrolled. The hypertriglyceridemic-waist (HTGW) phenotype was defined as elevated waist circumference (WC) and elevated triglyceride (TG) concentration. Linear and Multiple logistic regression models were used for measuring the association between HTGW phenotype and uric acid.Results: Total prevalence of hyperuricemia was 17.3% and the prevalence of hyperuricemia were 31.6 % in HTGW phenotype. Subjects with HTGW phenotype were more likely to have hyperuricemia (OR=1.47, 95%CI: 1.11–1.95, P=0.007) compared with subjects with NTNW group. Furthermore, the stratified analysis showed that the strongest positive association of HTGW phenotype with hyperuricemia was found in the subgroup of presence of CKD. The associations were all fully adjusted for confounding factors.Conclusion: Our study suggested a positive association between the HTGW phenotype and hyperuricemia in Chinese people. Further prospective studies are warranted to confirm our findings and to investigate the underlying biological mechanisms.
Synthesis, spectral, solvent dependent linear and nonlinear optical characteristics of (E)-N-(3-(3-(4(dimethylamino)phenyl)acryloyl) phenyl)quinolone-2-carboxamide
Authors: N SUDHA , Surendran R , Jeyaram S 
Published: March 2022

Abstract
This paper presents the synthesis of novel organic compound (E)-N-(3-(3 (4(dimethylamino)phenyl)acryloyl)phenyl)quinolone-2-carboxamide, also known as Quinolinecarboxamide Chalcone (QCC) using aldol condensation and carboxamide formation method. The organic sample QCC was examined by FT-IR, 1H NMR, 13C NMR and mass spectroscopic techniques, respectively. Linear and third-order nonlinear optical (TNLO) properties of QCC dissolved in polar solvents such as DMSO, DMF and Ethanol have also been studied. The order of nonlinear refractive index and nonlinear absorption coefficient of QCC was measured to be 10−11 m2/W and 10−5 m/W. The nonlinear refractive index (n2) of QCC was attributed to negative nonlinearity due to self-defocusing effect, and nonlinear absorption coefficient (β) indicates the behaviors of saturable absorption (SA) and reverse saturable absorption (RSA). The real and imaginary features of the TNLO susceptibility (χ(3)) of QCC in polar solvents were calculated to be the order of 10─7 esu. The spectral characteristics of solvent on TNLO susceptibility of QCC were discussed. The results divulged that the synthesized organic compound is a novel nonlinear optical (NLO) material for applications in photonics and optoelectronics.
Prognostic Implications and Immune Infiltration Analysis of SSBP1 in Lung Adenocarcinoma
Authors: Zhu Nengyang , Zhao Lei , Li Huming , Wang Jiaxin , Xu Yaodi , Meng Jiguang 
Published: March 2022

Abstract
Background
Single-Stranded DNA Binding Protein 1(SSBP1) has been found closely related to the malignant biological process of the tumor. However, the functions of SSBP1 in lung adenocarcinoma (LUAD) are still unclear. The present study explored the prognosis of SSBP1 in LUAD.
Methods
Oncomine, TIMER, and UALCAN were used to analyze the difference of SSBP1 expression in normal and tumor tissues, and HPA was used to analyze the immunohistochemical staining in tumor tissues. We also used Kaplan-Meier analysis to evaluate the impact of SSBP1 on LUAD patients’ survival. In addition, we used the TIMER database to explore the correlation between the expression of SSBP1 and tumor-infiltrating immune cells (TILs). Furthermore, we used STRING and GeneMANIA to build a network of protein-protein interaction (PPI) and perform GO analysis. Finally, we used CARE to evaluate the relationship between the expression of SSBP1 and the response of the drug.
Results
The expression of SSBP1 was up-regulated in the patients with LUAD and was related to the worse overall survival (OS) probability. And, SSBP1 was negatively associated with ImmuneScore, ESTIMATEScore, and StromalScore. In addition, SSBP1 expression has a negative correlation with the infiltration level of B cells, dendritic cells, CD4 + T cells, and macrophages. And, the expression of SSBP1 in B cells, CD8 + T cells, and dendritic cells (DC) was related to OS. Furthermore, a positive correlation was found between the expression SSBP1 and CARE.
Conclusion
SSBP1 is a potentially poor prognostic biomarker of LUAD and correlated with immune infiltrates in LUAD.
Barrier-Free Duct Muffler For Low-Frequency Sound Absorption
Authors: Gao Cong , Hu Chuandeng , Mei Jun , Hou Bo , Zhang Xianli , Du Zhanhang , Wen Weijia 
Published: March 2022

Abstract
We demonstrate a duct muffler design operating at frequency range that lower than 2000Hz. The device is composed of coupled annular Helmholtz Resonators (HRs) and installed as side branch of a circular ventilation tube to avoid affecting the ventilation. Porous material is employed for the purpose of generating asymmetric intrinsic loss status of the HR. Analytical model based on temporal coupled-mode theory is introduced and numerical simulation technique for structure design are introduced and verified. Experimental study verifies the effectiveness of the design methodology and illustrate that the device can achieve near perfect sound absorption in the desired frequency range. A symmetry configuration of HRs also experimentally proved to be able to conduct sound absorption for sound incident from both sides of the duct. This work provides a solid foundation for the application of the designed muffler and an analytical explanation of the corresponding sound absorption mechanisms.
Prognostic value of PET/CT and MR-based baseline radiomics among patients with Nasopharyngeal Carcinoma
Authors: Kulanthaivelu Roshini , Kohan Andres , Hinzpeter Ricarda , Liu Zhihui Amy , Hope Andrew , Huang Shao Hui , Waldron John , O'Sullivan Brian , Ortega Claudia , Metser Ur , Veit-Haibach Patrick 
Published: March 2022

Abstract
PurposeRadiomics is an emerging imaging assessment technique, which has shown promise predicting survival among nasopharyngeal carcinoma (NPC) patients. Studies so far have focused on MR-based radiomic analysis. The aim of our study was to evaluate the prognostic value of clinical and radiomic parameters derived from both PET/CT and MR.MethodsRetrospective evaluation of 124 NPC patients with PET/CT and radiotherapy planning MR (RP-MR). Primary tumors were segmented using dedicated software (LIFEx .version 6.1) from PET, CT, contrast enhanced T1-weighted (T1-w), and T2-weighted (T2-w) MR sequences with 376 radiomic features extracted. Summary statistics described patient, disease and treatment characteristics. Kaplan Meier (KM) method estimated overall survival (OS) and progression free survival (PFS). Clinical factors selected based on univariate analysis and multivariate Cox model were subsequently constructed with radiomic features added.ResultsThe final models comparing clinical, clinical + RP-MR, clinical + PET/CT and clinical + RP-MR + PET/CT for OS and PFS demonstrated that combined radiomics signatures were significantly associated with improved survival prognostication (AUC 0.62 vs 0.81 vs 0.75 vs 0.86 at 21 months for PFS and 0.56 vs 0.85 vs 0.79 vs 0.96 at 24 months for OS). Clinical + RP-MR features initially outperform clinical + PET/CT for both OS and PFS (< 18 months), and later in the clinical course for PFS (> 42 months).ConclusionOur study demonstrated that PET/CT-based radiomic features may improve survival prognostication among NPC patients when combined with baseline clinical and MR-based radiomic features.
A Clinically Annotated Post-Mortem Approach to Study Multi-Organ Somatic Mutational Clonality in Histologically Healthy Tissues
Authors: Luijts Tom , Elliott Kerryn , Siaw Joachim , Velde Joris , Beyls Elien , Claeys Arne , Lammens Tim , Larsson Erik , Willaert Wouter , Vral Anne , Eynden Jimmy Van den 
Published: March 2022

Abstract
Recent research on histologically healthy human tissues identified omnipresent mutational microclones, driven by somatic mutations known to be responsible for carcinogenesis (e.g., in TP53 or NOTCH1). These new insights are fundamentally changing current tumour evolution models, with broad oncological implications. Most studies are based on surgical remnant tissues, which are not available for many organs and rarely in a pan-organ setting (multiple organs from the same individual). Here, we describe an approach based on clinically annotated post-mortem tissues, derived from whole-body donors that are routinely used for educational purposes at human anatomy units. We validated this post-mortem approach using UV-exposed and unexposed epidermal skin tissues and confirm the presence of positively selected NOTCH1/2-, TP53- and FAT1-driven clones. No selection signals were detected in a set of immune genes or housekeeping genes. Additionally, we provide the first evidence for smoking-induced clonal changes in oral epithelia, likely underlying the origin of head and neck carcinogenesis. In conclusion, the whole-body donor-based approach provides a nearly unlimited healthy tissue resource to study mutational clonality and gain fundamental mutagenic insights in the presumed earliest stages of tumour evolution.
Offline rTMS inhibition of the bilateral dorsolateral prefrontal cortex impairs reappraisal efficacy
Authors: Wyczesany Miroslaw , Adamczyk Agnieszka K , Hobot Justyna , Barbalinardo Giansalvo , Adamczyk Przemysław , Labaza Adam , Ligeza Tomasz S 
Published: March 2022

Abstract
In the study we verified the causal role of the dorsolateral prefrontal cortex in performing reappraisal strategy of emotional control. Subjects underwent three sessions of inhibitory offline theta burst TMS stimulation that was targeted at either left dorsolateral, right dorsolateral or vertex area. During the experimental task they were asked to either passively watch or reappraise affective pictures. Efficacy of emotional control was quantified using the late positivity potential of the evoked brain responses. After both left and right dorsolateral stimulation, reappraisal was compromised compared to the vertex session. Worsening of affective control was reflected in earlier but not later time windows of the late positivity. It is suggested that inhibitory stimulation primarily affected top-down mechanism of attentional deployment necessary to focus on the content of experimental stimuli that enables elaboration of new, less negative interpretation of emotional content.
Image Based Disease Classification in Grape Leaves Using Convolutional Capsule Network
Authors: Andrushia Diana , Neebha Mary , Patricia Trephena , devi Uma , Anand N , Varshney Atul 
Published: March 2022

Abstract
Crop protection is the prime hindrance for food security. The plant diseases destroy the overall quality and quantity of the agricultural products. Grape is an important fruit and major source of vitamin C nutrients. The automatic decision making system plays a paramount role in agricultural informatics. This paper aims to detect the diseases in grape leaves using convolutional capsule networks. The capsule network is a promising neural network in the field of deep learning. This network uses a group of neurons as capsules and effectively represents spatial information of features. The novelty of the proposed work relies on the addition of convolutional layers before the primary caps layer which indirectly decrease the number of capsules and speed up the dynamic routing process. The proposed method is experimented with augmented and non-augmented datasets. It effectively detects the diseases of grape leaves with the accuracy of 99.12%. The performance of the method is compared with state-of-the art deep learning methods and produces reliable results.
Circular economy in fisheries: How is fish market waste managed in the Philippines?
Authors: De Ungria Sheralyn , Fernandez Lara Therese , Sabado Sophia Ellise , Santos Jeano Paulo , Sararaña Allysa Rose , VinceCruz-Abeledo Chona Camille 
Published: March 2022

Abstract
Improper management of fish waste has led to the Comprehensive National Fisheries Industry Development Plan to declare that Philippine fisheries are unsustainable. A considerable portion of fish waste is produced in wet markets, where bulk of fish products are sold. A comparison of existing practices in different localities can indicate the best points of intervention and identify existing traditional practices that can be promoted. This study interviewed fish vendors and fishers, and collected information at the market level, to determine existing fish waste management systems. From the responses gathered, the average daily production of fish waste in Philippine wet markets was 70.3 ± 65.4 kg, with no significant differences across locations (p = 0.2501). Of the fish waste produced, 32.3 ± 43.1 kg per wet market were disposed of, 18.9 ± 23.3 kg were sold, and 19.1 ± 21.9 kg were given away to stakeholders who re-use the fish waste. A significantly greater proportion of fish waste in rural areas were re-used compared to Metro Manila (p = 0.0311). Incentivizing innovations that maximize the use of derived fish waste at the municipal level, and promoting existing traditional practices, can prove effective in contributing to the Philippine circular economy while providing alternative sources of income for the stakeholders of the fisheries industry.
Pyroptosis-Related Genes Regulate Proliferation and Invasion of Pancreatic Cancer and Serve as the Prognostic Signature for Modeling Patient Survival
Authors: Song Wenjing , Liu Zhicheng , Wang Kunlei , Tan Kai , Zhao Anbang , Li Xinyin , Yuan Yufeng , Yang Zhiyong 
Published: March 2022

Abstract
Objective: Pancreatic ductal adenocarcinoma (PDAC) has high mortality and poor prognosis. Pyroptosis can influence the prognosis of patients by regulating the proliferation, invasion, and metastasis of cancer cells. However, the role of pyroptosis-related genes (PRGs) in PDAC remains unclear. Methods: In this study, based on the Cancer Genome Atlas (TCGA) cohort of PDAC samples, univariate Cox analysis and LASSO regression analysis were used to screen the prognostic PRGs and establish the gene signature. To further evaluate the functional significance of CASP4 and NLRP1 in PDAC, we also performed external validation of gene signature using data sets from the GEO database and conducted an in vitro study to examine their effects on PANC-1 cells. The signaling pathway involved in PRGs and its relationship with tumor immunity were also studied. Finally, the regulators upstream of PRGs were predicted by starbase and the relationship between PRGs and anticancer drug sensitivity was analyzed. Results: A risk prediction model based on CASP4 and NLRP1 was established, which can distinguish high-risk patients from low-risk patients (P<0.001). Both internal validation and external GEO data sets validation demonstrate good predictive capability of the model (AUC=0.732, AUC=0.802, AUC=0.632, P<0.05). In vitro, CCK8 and Transwell assay suggested that CASP4 may accelerate the progression of PDAC by promoting proliferation and migration of pancreatic cancer cells, while NLRP1 has been found to have tumor suppressive effect. It should be noted that after CASP4 was knocked down, the expression levels of acetyl-CoA carboxylase and SREBP-2 were decreased, and the number of lipid droplets was also significantly reduced. Besides, the expression level of CASP4 was positively correlated with KRAS and P53 mutations. Finally, PRGs were significantly associated with the sensitivity to the inhibitors of AKT and MEK. Conclusion: PRGs played an important role in tumor immunity and had potential diagnostic, therapeutic and prognostic value for PDAC. In especial, CASP4 can promote tumor progression by promoting the synthesis and accumulation of fatty acids.
Characrerization of Arba Minch University General Hospital, Construction Site, Using Seismic Refraction Method in Arba Minch Town of Southern Ehiopia
Authors: Tesfaw Yalem 
Published: March 2022

Abstract
The seismic refraction method is one of geophysical technic which is frequently used to determine the characteristics of soils and rocks (Ugwu, 2008; Ayolabi et al.,2009). This geophysical method is based on measuring the arrival times of seismic waves refracted by the interfaces between layers of ground, characterized by different propagation speeds. The energy source is represented by an impact on the surface. The energy radiates from the “shot point,-travelling both directly in the uppermost layer (direct arrivals), and deep down and laterally along layers at a higher speed (refracted arrivals)-then returning to the surface, where it is measured through the spreading of geophones.
Headache attributed to transient ischaemic attack: a prospective retrospective baseline study
Authors: Tan Ge , Zang Jiali , Liu Qing , Li Qin , Liu Qinlin , Yu Xiran 
Published: March 2022

Abstract
Background: It is difficult to discriminate between headache attributed to transient ischaemic attack from migraine with aura. We studied the characteristics of headache-attributed transient ischaemic attacks to provide clinical evidence for the treatment of headache attributed to transient ischaemic attack.Methods: We performed a prospective study with a retrospective baseline evaluation of all patients with headaches attributed to transient ischaemic attack (22) during a three-year period. The demography, vascular risk factors and clinical information were collected. The following typical symptoms were evaluated by an ABCD2 score of 4 or greater. The headache characteristics were collected within a 24-hour interval after the onset of transient ischaemic attack.Results: Headache that is attributed to transient ischaemic attack accounted for 8.2% (22/269) of the patients with transient ischaemic attack. Headache attributed to transient ischemic attack was more common in women (68.2%, 15/22) and in posterior circulation of transient ischemic attack (59.1%,13/22). These types of headaches were similar to tension-type headache and included a bilateral location (72.7%, 16/22), a dull quality (72.7%, 16/22), and a moderate intensity (54.5%, 12/22).Conclusions:Our study showed that headache attributed to transient ischaemic attack was similar to a tension-type headache and was more common in women and in patients with posterior circulation transient ischaemic attacks.