bluuebunny/crossref_metadata_2025_split huggingface dataset:
(C)onsumer focused (E)ducation on p(A)racetamol (S)ide (E)ffects, i(N)adequate (O)utcomes and (W)eaning (CEASE NOW) for individuals with low back pain: results of a feasibility study
Authors: Patterson Thomas , Turner Justin , Gnjidic Danijela , Mintzes Barbara , Bennett Carol , Bywaters Lisa , Clavisi Ornella , Baysari Melissa , Ferreira Manuela , Beckenkamp Paula , Ferreira Paulo 
Published: November 2022

ObjectivesTo determine the feasibility of a patient-education booklet to support patients with low back pain (LBP) to reduce paracetamol intake.DesignSingle group, repeated measures feasibility study.SettingCommunity.ParticipantsAdults experiencing LBP of any kind and self-reporting consumption of paracetamol for LBP weekly for at least 1 month were invited to participate.InterventionParticipants received a patient-education booklet 1 week after the baseline measures were collected. The intervention was designed to change beliefs, increase knowledge and self-efficacy to deprescribe paracetamol for their LBP and create discussion with a health professional through the mechanisms of motivation, capacity and opportunity.Primary outcome measuresFeasibility of recruitment procedures, data collection and acceptability of the intervention.Secondary outcome measuresChanges in motivation, self-efficacy, opportunity to deprescribe paracetamol for their LBP, paracetamol usage and LBP clinical outcomes at baseline, 1-week and 1-month follow-up.ResultsA total of 24 participants were recruited into the study within the timeframe of 3 months from study advertisement and all completed the study follow-up. There were no missing data for any outcome measure across all follow-up points, 22 (91.6%) participants were willing to participate in a future randomised control trial (RCT) and over 60% of participants responded positively to questions regarding acceptability of the patient-educational booklet. Overall, at the 1-month follow-up, approximately two thirds (15/24) of participants had an increase in motivation and self-efficacy scores and had discussed or intended to discuss their paracetamol use for LBP with a health professional.ConclusionsThe results of this study demonstrate that the patient-education booklet is feasible to implement, and both the intervention and study design were well-received by participants. This study supports the undertaking an RCT to assess the effects of the patient-education booklet on deprescribing paracetamol in people with LBP.
We want more! Examining the perceived training and information needs of health and fitness practitioners about disability and physical activity
Authors: Leo Jennifer , Tomasone Jennifer R. , Bassett-Gunter Rebecca L. , Knibbe Tara Joy , Latimer-Cheung Amy 
Published: November 2022

A lack of disability-specific knowledge among practitioners poses a significant barrier to physical activity (PA) participation for persons with physical disabilities (PWPDs). This study aimed to identify perceived training needs of health and fitness practitioners to support PA for PWPDs. Canadian health and fitness practitioners ( n = 115; 81% female) completed an online survey. More specialized training and access to information about PA for PWPDs are needed. In-person training, webinars, and lived experiences of PWPDs are recommended.
A combined approach to the analysis of space and ground experimental data within a simplified E$$_6$$SSM
Authors: Khalil Shaaban , Kowalska Kamila , Moretti Stefano , Rojas-Ciofalo Diana , Waltari Harri 
Published: November 2022

AbstractWithin the Exceptional Supersymmetric Standard Model (E$$_6$$6SSM), we investigate signatures at the Large Hadron Collider (LHC) for a long-lived charged inert higgsino, which is degenerate with the inert neutralino at tree level and a small mass splitting is generated at the loop level, resulting in a lifetime$$\mathcal{O}(0.02)$$O(0.02)nanoseconds. We focus on the most sensitive search for long-lived charged inert higgsino decays to the lightest neutral inert higgsino dark matter and very soft charged leptons, which are eventually stopped in the detector resulting in a disappearing-track signal. Furthermore, we study the displaced vertex signature of the inert chargino in the case where it is produced via the$$Z^{\prime }$$Z′portal. We illustrate how difficult it is to construct displaced vertices in this class of models, though some evidence could be gained at the High Luminosity LHC. Finally, we compare the spin independent and spin dependent cross sections of the lightest inert higgsino DM to those of current direct detection experiments, proving that it is possible to gain sensitivity to the active DM component of this scenario in the near future. The combination of these signatures with the one emerging from$$Z'$$Z′production and decay via Drell–Yan, which can be characterised as belonging to the E$$_6$$6SSM via both the cross section and Forward–Backward Asymmetry, could point uniquely to this non-minimal realisation of Supersymmetry.
Chapter 7. Alternative North Sea Jurassic sequence stratigraphic schemes
Authors: Copestake Philip 
Published: November 2022

Abstract
This chapter reviews previously published North Sea Jurassic sequence stratigraphy schemes. Some of these works have applied the originally published J sequence schemes, while 18 have established new schemes. The most significant of these are discussed and compared to the newly defined J sequences. Most of these additional documented schemes have been defined for the Upper Jurassic interval, with a more limited number of schemes for the Lower and Middle Jurassic. Different authors have adopted a wide range of sequence notation methods while none of the publications describing the new sequence schemes has offered detailed sequence definitions. Due to the ensuing confusion, it is recommended that a more formal method of sequence definition is adopted in future sequence stratigraphic studies. In intervals in which reservoir successions are developed, such as the Fulmar Sandstone Member in the J56–J63 sequences, particularly in fields in which extensive coring has taken place, authors have usually been able to recognize additional sequences, which are probably at fourth-order scale, at a higher resolution than the defined third-order J sequences.
CP1 and Tribicarb-3D: unique long-term and large-scale
in situ
migration tests in Boom Clay at the HADES Underground Research Laboratory
Authors: Aertsens Marc , Weetjens Eef , Govaerts Joan , Maes Norbert , Brassinnes Stéphane 
Published: November 2022

Abstract

Assessing the long-term safety of a deep geological repository for the disposal of radioactive waste depends on an adequate understanding of the processes governing radionuclide transport. From the early days of the research on geological disposal in clay in Belgium, large-scale, long-term
in situ
migration experiments were started to test whether our knowledge acquired about small-scale samples can be scaled up in time and space. These experiments use multi-filter piezometers to introduce radiotracers in a ‘source filter’ and monitor their breakthrough in ‘monitoring filters’. The CP1 experiment started in 1988 and used HTO as a tracer, while the Tribicarb-3D started in 1995 and used a cocktail of HTO and

H

14

CO

3
−

. At the start of these experiments, blind predictions were made based on lab-derived parameters and a simple representation of the hydrological system. Several decades later, these blind predictions still describe the data remarkably well. These tests provide valuable data for upscaling and validating the transport models in Boom Clay and allow us to estimate transport parameters at a larger scale. They provide strong arguments that the radiological safety of a deep geological repository in a clay rock can be guaranteed.
Metagenomic identification of novel viruses of maize and teosinte in North America
Authors: Lappe Ryan R. , Elmore Manjula G. , Lozier Zachary R. , Jander Georg , Miller W. Allen , Whitham Steven A. 
Published: November 2022

Abstract
Background
Maize-infecting viruses are known to inflict significant agronomic yield loss throughout the world annually. Identification of known or novel causal agents of disease prior to outbreak is imperative to preserve food security via future crop protection efforts. Toward this goal, a large-scale metagenomic approach utilizing high throughput sequencing (HTS) was employed to identify novel viruses with the potential to contribute to yield loss of graminaceous species, particularly maize, in North America.

Results
Here we present four novel viruses discovered by HTS and individually validated by Sanger sequencing. Three of these viruses are RNA viruses belonging to either the Betaflexiviridae or Tombusviridae families. Additionally, a novel DNA virus belonging to the Geminiviridae family was discovered, the first Mastrevirus identified in North American maize.

Conclusions
Metagenomic studies of crop and crop-related species such as this may be useful for the identification and surveillance of known and novel viral pathogens of crops. Monitoring related species may prove useful in identifying viruses capable of infecting crops due to overlapping insect vectors and viral host-range to protect food security.
The effect of SNPs in lncRNA as ceRNA on the risk and prognosis of hepatocellular carcinoma
Authors: Mo Han , Wang Xi , Ji Guohua , Liang Xiao , Yang Yi , Sun Wenjing , Jia Xueyuan , Xu Lidan , Qiao Yuandong , Zhou Henan , Zhao Wenhui , Fu Songbin , Zhang Xuelong 
Published: November 2022

Abstract
Background
Most susceptible loci of hepatocellular carcinoma (HCC) identified by genome-wide association studies (GWAS) are located in non-coding regions, and the mechanism of action remains unclear. The objective of this study was to explore the association of single nucleotide polymorphisms (SNPs) on long non-coding RNAs (lncRNAs) that affect competing endogenous RNAs (ceRNA) regulation mechanism with the risk and prognosis of HCC.

Methods
Based on a set of bioinformatics strategies, eight lncRNA genes that affect HCC through the mechanism of lncRNA-mediated ceRNA were systematically screened, and 15 SNPs that affect microRNA (miRNA) binding in these lncRNA genes were annotated. Genotyping was performed in 800 HCC cases and 801 healthy controls to examine associations of these SNPs with HCC in a northeastern Chinese Han population.

Results
The GG, GC and GG + GC genotypes of HOTAIR rs7958904 were associated with a 0.65, 0.59 and 0.63-fold decreased HCC risk, respectively. In addition, HCC patients with PVT1 rs3931282 AA + GA genotypes were less prone to develop late-stage cancers in a stratified analysis of clinical characteristics. When stratified by clinical biochemical indexes, rs1134492 and rs10589312 in PVT1 and rs84557 in EGFR-AS1 showed significant associations with aspartate aminotransferase (AST), alanine aminotransferase (ALT) or AST/ALT ratio in HCC patients. Furthermore, we constructed potential ceRNA regulatory axes that might be affected by five positive SNPs to explain the causes of these genetic associations.

Conclusions
HOTAIR rs7958904, PVT1 rs3931282, rs1134492 and rs10589312, and EGFR-AS1 rs84557 might be predictors for HCC risk or prognosis. Our results provide new insights into how SNPs on lncRNA-mediated ceRNAs confer interindividual differences to occurrence and progression of HCC.
Applied causal inference methods for sequential mediators
Authors: Zugna D , Popovic M , Fasanelli F , Heude B , Scelo G , Richiardi L 
Published: November 2022

Abstract
Background
Mediation analysis aims at estimating to what extent the effect of an exposure on an outcome is explained by a set of mediators on the causal pathway between the exposure and the outcome. The total effect of the exposure on the outcome can be decomposed into an indirect effect, i.e. the effect explained by the mediators jointly, and a direct effect, i.e. the effect unexplained by the mediators. However finer decompositions are possible in presence of independent or sequential mediators.

Methods
We review four statistical methods to analyse multiple sequential mediators, the inverse odds ratio weighting approach, the inverse probability weighting approach, the imputation approach and the extended imputation approach. These approaches are compared and implemented using a case-study with the aim to investigate the mediating role of adverse reproductive outcomes and infant respiratory infections in the effect of maternal pregnancy mental health on infant wheezing in the Ninfea birth cohort.

Results
Using the inverse odds ratio weighting approach, the direct effect of maternal depression or anxiety in pregnancy is equal to a 59% (95% CI: 27%,94%) increased prevalence of infant wheezing and the mediated effect through adverse reproductive outcomes is equal to a 3% (95% CI: -6%,12%) increased prevalence of infant wheezing. When including infant lower respiratory infections in the mediation pathway, the direct effect decreases to 57% (95% CI: 25%,92%) and the indirect effect increases to 5% (95% CI: -5%,15%). The estimates of the effects obtained using the weighting and the imputation approaches are similar. The extended imputation approach suggests that the small joint indirect effect through adverse reproductive outcomes and lower respiratory infections is due entirely to the contribution of infant lower respiratory infections, and not to an increased prevalence of adverse reproductive outcomes.

Conclusions
The four methods revealed similar results of small mediating role of adverse reproductive outcomes and early respiratory tract infections in the effect of maternal pregnancy mental health on infant wheezing. The choice of the method depends on what is the effect of main interest, the type of the variables involved in the analysis (binary, categorical, count or continuous) and the confidence in specifying the models for the exposure, the mediators and the outcome.
Exosomal lncRNA HOTAIR induce macrophages to M2 polarization via PI3K/ p-AKT /AKT pathway and promote EMT and metastasis in laryngeal squamous cell carcinoma
Authors: Wang Jingting , Wang Nan , Zheng Zeyu , Che Yanlu , Suzuki Masanobu , Kano Satoshi , Lu Jianguang , Wang Peng , Sun Yanan , Homma Akihiro 
Published: November 2022

AbstractExosomes are a new way of the communication between the tumor cell and macrophage in the micro-environment. The macrophage can be induced to different phenotypes according to the different tumors. In the present study, long-chain noncoding RNA HOTAIR (lncRNA HOTAIR) was highly expressed in LSCC and exosomes. The pathway of exosomal lncRNA HOTAIR inducing macrophage to M2 polarization in the LSCC was investigated. The carcinoma tissues and adjacent tissues were collected from 104 LSCC cases, and the positive relationship between CD163-/CD206-M2 macrophage infiltration and clinical phase, lymph node spreading and pathological phase in LSCC was observed. To examine the role of exosomal lncRNA HOTAIR, macrophages were co-cultured with LSCC-exosomes of high lncRNA HOTAIR expression or transferred with HOTAIR mimics. It was suggested that exosomal lncRNA HOTAIR can induce macrophages to M2 polarization by PI3K/p-AKT/AKT signaling pathway. Furthermore, exo-treated M2 macrophages facilitate the migration, proliferation, and EMT of LSCC.
Upregulation of PCED1B-AS1 in proliferative diabetic retinopathy and its involvement in retinal vascular endothelial cell proliferation
Authors: Wang Xuyang , Chen Wangling , Lao Wei , Chen Yunxin 
Published: November 2022

Abstract
Background
This study was to assess the diagnostic value of PCED1B-AS1 for proliferative diabetic retinopathy (PDR) and investigate the involvement of PCED1B-AS1 in PDR.

Methods
The vitreous and blood specimens from 37 subjects with PDR and 21 non-diabetics were examined by reverse transcription quantitative PCR to determine the PCED1B-AS1 level. The two groups were age- and gender-matched. Receiver operating characteristic (ROC) curves were plotted to visually illustrate the diagnostic ability of PCED1B-AS1. Human retinal Müller glial cells were studied by ELISA. Proliferation and migration of human retinal microvascular endothelial cells (HRMECs) were assessed in vitro.

Results
Significant increases of PCED1B-AS1 levels were observed in the vitreous samples and CD34 + VEGFR-2 + cells from blood samples of diabetic subjects with PDR, compared with those of non-diabetics. The ROC curve based on the vitreous PCED1B-AS1 levels revealed an AUC of 0.812, while the ROC curve based on the PCED1B-AS1 levels in CD34 + VEGFR-2 + cells from blood samples revealed an AUC of 0.870. In Müller cell cultures, PCED1B-AS1 siRNA significantly attenuated VEGF and MCP-1 upregulation which were induced by CoCl2 and TNF-α. Additionally, PCED1B-AS1 siRNA attenuated VEGF-induced proliferation and migration in HRMECs.

Conclusion
This study revealed the potential of PCED1B-AS1 as a diagnostic biomarker for PDR. In vitro data point to the anti-angiogenic and anti-proliferation effects of PCED1B-AS1.
Fear of contagion, emotional stress and coping strategies used by adults during the first wave of the COVID-19 pandemic in Nigeria
Authors: Folayan Morenike Oluwatoyin , Ibigbami Olanrewaju , Brown Brandon , El Tantawi Maha , Aly Nourhan M. , Zuñiga Roberto Ariel Abeldaño , Abeldaño Giuliana Florencia , Ara Eshrat , Ellakany Passent , Gaffar Balgis , Al-Khanati Nuraldeen Maher , Idigbe Ifeoma , Ishabiyi Anthonia Omotola , Jafer Mohammed , Khan Abeedha Tu-Allah , Khalid Zumama , Lawal Folake Barakat , Lusher Joanne , Nzimande Ntombifuthi P. , Popoola Bamidele Olubukola , Quadri Mir Faeq Ali , Roque Mark , Okeibunor Joseph Chukwudi , Nguyen Annie Lu 
Published: November 2022

Abstract
Background
The COVID-19 pandemic has induced high levels of stress. The aim of the study was to assess the relationship between emotional stress (COVID-19 related fear, anger, frustration, and loneliness) and the use of coping strategies among adults in Nigeria during the COVID-19 pandemic.

Methods
Data from adults aged 18 years and above were collected through an online survey from July to December 2020. The dependent variables were COVID-19 related fear (fear of infection and infecting others with COVID-19), anger, frustration, and loneliness. The independent variables were coping strategies (use of phones to communicate with family and others, video conferencing, indoor exercises, outdoor exercises, meditation/mindfulness practices, engaging in creative activities, learning a new skill, following media coverage related to COVID-19) and alcohol consumption. Five logistic regression models were developed to identify the factors associated with each dependent variables. All models were adjusted for sociodemographic variables (age, sex at birth, and the highest level of education).

Results
Respondents who consumed alcohol, followed media coverage for COVID-19 related information, and who spoke with friends or family on the phone had higher odds of having fear of contracting COVID-19 or transmitting infection to others, and of feeling angry, frustrated, or lonely (p < 0.05). Respondents who exercised outdoors (AOR: 0.69) or learned a new skill (AOR: 0.79) had significantly lower odds of having fear of contracting COVID-19. Respondents who practiced meditation or mindfulness (AOR: 1.47) had significantly higher odds of feeling angry. Those who spoke with friends and family on the phone (AOR: 1.32) and exercised indoors (AOR: 1.23) had significantly higher odds of feeling frustrated. Those who did video conferencing (AOR: 1.41), exercised outdoors (AOR: 1.32) and engaged with creative activities (AOR: 1.25) had higher odds of feeling lonely.

Conclusion
Despite the significant association between emotional stress and use of coping strategies among adults in Nigeria during the COVID-19 pandemic, it appears that coping strategies were used to ameliorate rather than prevent emotional stress. Learning new skills and exercising outdoors were used to ameliorate the fear of contracting COVID-19 in older respondents.
The Bergen 4-day treatment for panic disorder: replication and implementation in a new clinic
Authors: Iversen Hanne Moe , Eide Thorstein Olsen , Harvold Mathea , Solem Stian , Kvale Gerd , Hansen Bjarne , Hagen Kristen 
Published: November 2022

Abstract
Background
Bergen 4-day treatment (B4DT) is a concentrated exposure-based treatment (cET), where the patient receives concentrated, individually tailored cognitive behavioral therapy (CBT) during four consecutive days. Previous findings have indicated that B4DT could be a promising treatment for panic disorder (PD).

Aim
The aim of the present study was to evaluate the implementation of B4DT for panic disorder with- and without agoraphobia, at a new clinic. This is the first replication study for B4DT on panic disorder.

Method
Thirty consecutively recruited patients with PD were included in an open trial design. Assessment of symptoms of panic disorder were measured with Panic Disorder Severity Scale (PDSS), while symptoms of generalized anxiety were assessed by Generalized Anxiety Disorder-7 (GAD-7) and depressive symptoms by Patient Health Questionnaire (PHQ-9) pre-treatment, post-treatment and at 3-month follow-up. Treatment satisfaction was measured with Client Satisfaction Questionnaire (CSQ-8) post-treatment.

Results
The results showed a significant reduction in symptom severity from pre-treatment to post-treatment (d = 4.32), and at 3-month follow-up (d = 4.91). The proportion of patients classified as fulfilling the criteria for remission was 80.0% at post-treatment and 86.7% at follow up. There was a significant reduction in symptoms of depression and generalized anxiety. Treatment satisfaction was high and none of the patients dropped out.

Conclusion
The current study replicated the results from the original study and indicate that the treatment can be successfully implemented at new clinics. B4DT may be a promising treatment for panic disorder and comorbid symptoms of generalized anxiety and depression. Larger and more controlled studies are needed to establish the efficacy of B4DT for panic disorder.
Teriparatide treatment in severe osteoporosis – a controlled 10-year follow-up study
Authors: Kontogeorgos Georgios , Krantz Emily , Trimpou Penelope , Laine Christine M. , Landin-Wilhelmsen Kerstin 
Published: November 2022

Abstract
Background
Teriparatide was the first anabolic agent recommended for the treatment of osteoporosis. Long-term real-world, controlled studies are not available. The purpose was to evaluate the long-term effects of treatment with teriparatide on fractures and Health Related Quality of Life in subjects with established osteoporosis in comparison with placebo treated patients with osteoporosis and the general population.

Methods
A 10-year follow-up was performed after a prospective, open-labelled study with teriparatide 20 μg given subcutaneously daily for a mean of 18 months (range 14–24 months) in 40 women, mean age 69 years, with osteoporosis and vertebral compression. Placebo treated women, n = 25, mean age 60 years, from a randomized, double-blind, placebo-controlled growth hormone trial with daily subcutaneous injections for 18 months, with osteoporosis were used as controls. Dual energy x-ray absorptiometry and questionnaires were performed at start, after 18 months, after 36 months and after 10 years. Women, n = 233, of similar age from a random population sample, also served as controls and were followed in parallel. All fractures were X-ray verified.

Results
Fractures decreased from 100 to 35% in the teriparatide treated patients (p < 0.0001) to similar levels as in the population sample, 25 to 28% at start and after 10 years, respectively. Bone mineral density increased on teriparatide but returned to levels at treatment start after 10 years. Health Related Quality of Life was lower in the teriparatide group than in the population (p < 0.001) before and, after treatment and at 10 years.

Conclusions
Anabolic hormonal treatment with teriparatide reduced fracture prevalence to similar levels as in the general population at 10 years’ follow-up. Health Related Quality of Life was low in osteoporosis and unaffected by bone specific treatment.