bluuebunny/crossref_metadata_2025_split huggingface dataset:
Klotho Polymorphism in Association With Serum Testosterone and Knee Strength in Women After Testosterone Administration
Authors: Ekström Lena , Knutsson Jona Elings , Stephanou Christina , Hirschberg Angelica Lindén 
Published: May 2022

Administration of testosterone (T) is associated with increased serum T concentrations and improved physical performance in women. However, the inter-individual variation in T concentrations after T treatment is large and may in part be due to genetic variations. Serum T, as well as dihydrotestosterone (DHT), androstenedione (A) and the T/A ratio have been suggested as promising doping biomarkers for testosterone intake. Here, polymorphisms in androgen metabolic enzyme genes have been investigated in healthy women prior to and after 10 weeks administration of testosterone cream. Klotho is a protein that has been associated with anaerobic strength and here a genetic variation in klotho gene was studied in relation to performance as measured by isokinetic knee strength, as well as to serum androgen disposition. The AKR1C3 genotype (rs12529) was associated with serum T levels at baseline, whereas serum concentrations post T treatment did not differ between genotypes. The SLCO2B1 (rs12422149) and UGT2B17 deletion polymorphisms were not associated with serum concentration of either T, DHT or A. The klotho polymorphism (rs9536314) was associated with serum concentrations of both total T and T/A ratio after T administration. Individuals with the GT genotype increased T concentrations and T/A ratio more than women homozygous for the T allele. No significant difference in the association of klotho genotype with knee muscle strength was observed between placebo and T treatment. However, individuals homozygous for the T allele showed higher isometric mean torque scores at exit than GT subjects after T administration. This is the first time a genotype has been associated with androgen concentrations after T administration and muscle strength in women. Our results imply that subjects with a polymorphism in klotho may be more prone to detection using serum T and A as biomarkers.
Safeguarding Reimagined: Centering Athletes’ Rights and Repositioning Para Sport to Chart a New Path
Authors: Tuakli-Wosornu Yetsa A. , Kirby Sandra L. 
Published: May 2022

ObjectivesPara sport has much to teach the broader sports world about safeguarding and athlete protections. By centering athletes’ human rights and underlining the rights-based philosophical underpinnings of the Paralympic Movement, we outline how sport can be safer to all players, coaches, and other participants.MethodsWe address global Human Rights conventions and their application to Para and non-disabled sport. Safe Sport is positioned as a matter of human rights. The nature of interpersonal violence that human beings experience within and outside sport is discussed. The intersectionality of vulnerable identities (related to gender, sexuality, disability, ethnicity, etc.) is reviewed in some detail.ResultsRights violations in Para and non-disabled sport illustrate both individual and organizational vulnerabilities. Individual- and organizational-level drivers of abuse, as well as various modes and types of abuse observed in Para sport, are relevant in all sport settings and should be centered in global sport safeguarding work. The rights-based core of Para and similar sports movements, exemplifies this.ConclusionFrom a Para-informed vantage point, we issue a call to action, where interpersonal violence in sport is reduced by leveraging relevant elements of the Paralympic Movement. This call asks all sport participants to reject a purely capitalist approach to sport and follow a Para sport paradigm; which embodies human achievement (including sporting success), reflects human rights and inherent human dignity, and requires a higher standard of behaviour.
Changes in Indices of Steatosis and Fibrosis in Liver Grafts of Living Donors After Weight Reduction
Authors: Choi Jaehyuk , Choi YoungRok , Hong Su young , Suh Sanggyun , Hong Kwangpyo , Han Eui Soo , Lee Jeong-Moo , Hong Suk Kyun , Yi Nam-Joon , Lee Kwang-Woong , Suh Kyung-Suk 
Published: May 2022

BackgroundA short-term weight reduction program for potential living donors was introduced to reduce the extent of hepatic steatosis prior to liver transplantation. We aimed to investigate changes in non-invasive hepatic steatosis and fibrosis indices among those who completed the program.MethodsAmong 1,950 potential living liver donors between January 2011 and May 2019, 160 living donors joined the weight reduction program. The prospectively collected clinical data of these potential liver donors were analyzed retrospectively. Hepatic steatosis and fibrosis scores were determined using the fatty liver index (FLI), hepatic steatosis index (HSI), and NAFLD fibrosis score (NFS) and compared to MR spectroscopy (MRS) fat fraction results before and after weight reduction.ResultsThirty-nine potential living donors who had undergone MRS both before and after weight reduction were included in the analysis. Their body weight decreased from 78.02 ± 10.89 kg to 72.36 ± 10.38 kg over a mean of 71.74 ± 58.11 days. FLI, HSI, and MRS values decreased significantly from 41.52 ± 19.05 to 24.53 ± 15.93, 39.64 ± 3.74 to 35.06 ± 3.82, and 12.20 ± 4.05 to 6.24 ± 3.36, respectively. No significant decreases in NFS were observed. There was a significant correlation between the extent of HSI change and the extent of MRS change (R2 value = 0.69, P &lt; 0.001), although there was no correlation between MRS and FLI.ConclusionThe weight reduction program significantly improved non-invasive indices of hepatic steatosis over a short period. HSI may allow for prediction of simple decreases in hepatic steatosis.
Olecranon With Concomitant Radial Head Fracture: A Case Series of Fifteen Patients
Authors: Ditsios Konstantinos , Pitsilos Charalampos , Katsimentzas Triantafyllos , Konstantinou Panagiotis , Christidis Panagiotis , Papadopoulos Pericles 
Published: May 2022

IntroductionSimultaneous olecranon and radial head fractures are rare injuries and due to this factor, the outcome of the selected therapy is not widely studied. The aim of this study is to report and evaluate the functional outcome of the surgical treatment of simultaneous olecranon and radial head fractures.Materials and MethodsThis is a retrospective study of fifteen patients with concomitant olecranon and radial head fractures presenting to our orthopedic department between 2015 and 2020. Olecranon fractures were classified by Mayo classification and radial head fractures by Mason classification and were managed appropriately. Main outcome measures include range of elbow extension-flexion, pronation-supination, Broberg and Morrey rating system score, and quickDASH score.ResultsOur study included 6 females and 9 males with a mean age of 50 (r, 25–73). The mean of follow-up was 31 months (r, 3–51). Olecranon fractures were fixed with tension band with K-Wires or intramedullary compression screw or locking plate. Radial head fractures were fixed with headless compression screws or mini plate or replaced (radial head arthroplasty). Postoperatively, an average 115° extension-flexion arc and 135° pronation-supination arc was noted. The mean Broberg and Morrey rating system score was 78 and the mean quick DASH score was 25, indicating a good result. Two cases of heterotopic ossification were present and no nonunion was noted.ConclusionSurgical management of concomitant olecranon and radial head fractures with appropriate technique can result in the restoration of a functional movement arc and a satisfactory outcome.
Evaluación del uso de las TIC en la enseñanza de idiomas
Authors: Guevara-Bazán Isaí Alí 
Published: May 2022

En la Universidad Veracruzana, los Centros de Idiomas preponderan la innovación educativa no solo en la aplicación estrictamente técnica, sino en nuevos procesos de enseñanza que agilicen la aplicación de las TIC para el mejoramiento de la calidad educativa, la calidad de vida, la sustentabilidad y el desarrollo integral del alumno. Por lo tanto, se requiere usar adecuadamente las nuevas tecnologías. Para ello se propone crear una perspectiva analítica de las mejores formas de implementar las TIC.
Se realiza una investigación aplicada de tipo descriptivo de campo. Incluye métodos de recolección, análisis e interpretación cuantitativos.
Los temas que se analizaron fueron tomados de los criterios de la UNESCO (UNESCO-IEU, 2010): Uso de las TIC para ampliar las oportunidades de enseñanza y aprendizaje, para perfeccionar el currículo, mejorar la calidad de los logros educativos y promover reformas educativas, para fomentar la equidad y la educación inclusiva, para la adquisición de habilidades laborales y competencias prácticas y para la integración de las TIC a la educación en cooperación con el sector privado.
A partir de los criterios generales mencionados, se analizaron los ámbitos del uso de la tecnología en el salón de clase, fuera del salón de clases, para el aprendizaje, en la administración escolar y para la sustentabilidad. Se realizó una descripción e interpretación de los datos recaudados y se especificó el conjunto de propiedades y características del fenómeno estudiado. Los resultados muestran la necesidad de un mejoramiento del uso de las TIC en el plano de los recursos humanos, la implementación tecnológica en los espacios educativos, la integración de las TIC de manera más organizada y con mejor liderazgo. Indica también que existe valiosa integración de las TIC en implementación individualizada de herramientas digitales para el aprendizaje y excelente habilitación tecnológica de algunos docentes. Sin embargo, se presenta aún una brecha en el plano de la capacitación y adecuaciones tecnológicas para alcanzar los estándares sugeridos por la UNESCO.
Reconfiguración del sujeto y la subjetividad en el campo de la educación.
Authors: Madrigal-Segura Rubén , Castañeda-Reyes María Del Rosario 
Published: May 2022

El objeto de conocimiento de nuestra investigación de cuerpo académico es la reconfiguración educativa a partir de las identidades y prácticas. El presente artículo tiene como objetivo dar a conocer la forma en que utilizamos el triángulo metodológico propuesto por Rosa Nidia Buenfil en nuestro objeto de conocimiento en dos Líneas de Generación y Aplicación del Conocimiento: Trayectorias académicas y Arte y estética. Nos planteamos una pregunta para el presente escrito ¿cómo aprovechar el triángulo metodológico en una investigación educativa de un cuerpo académico? El escrito se encuentra organizado en seis apartados introducción, punto de partida, metodología de la investigación, resultados, conclusiones y referencias. En la introducción planteamos lo expuesto en líneas arriba. En el punto de partida reconocemos que pertenecemos al Instituto Superior de Ciencias de la Educación del Estado de México y eso marca una tradición francófona como distinción en el sentido teórico metodológico. La metodología que asumimos en el proceso de investigación se aleja de los protocolos de investigación que se asumen como pasos; es un proceso que se construye con ajustes permanentes y consta de siete dimensiones, a partir del triángulo: pregunta de investigación, referente teórico y referente empírico. Las dimensiones que más se trabajan en el escrito son cinco, las restantes solo se hacen mención porque son parte de la conclusión de la investigación y ésta se encuentra en proceso. Así pues, la delimitación de la pregunta, las posiciones ontológicas y epistemológicas, el cuerpo conceptual y lógica de razonamiento, el referente empírico y, el proceso de ajuste constante entre preguntas, teorías y referente empírico son las dimensiones desarrolladas en el artículo. El siguiente apartado da cuenta de los resultados del proceso de investigación en torno a la utilidad del triángulo metodológico. Presentamos otro apartado sobre las conclusiones. Por último, se presentan las referencias.
Życie i aktywność Wacława Raszka (1764–1837) w świetle źródeł
Authors: Bujas-Poniatowska Jolanta , Godek Andrzej Edward , Poniatowski Kamil 
Published: May 2022

Działający na przełomie XVIII i XIX w. Wacław Raszek należy do grona muzyków, o których – mimo zainteresowania ze strony badaczy – wiadomo nader niewiele. Niejasności dotyczące właściwie wszystkich podstawowych informacji na temat muzyka, tj.: jego imienia, lat życia, ośrodków, w których przebywał czy przypisywanych mu utworów muzycznych, doprowadziły do licznych nieścisłości, pomyłek i niesprawdzonych hipotez.
Zgodnie z obecną wiedzą można stwierdzić, że Wacław (a właściwie Ignacy Wacław) Raszek urodził się w Rychnovie nad Kněžnou w północnych Czechach, jako drugie z dwojga bliźniąt ochrzczonych pierwszego lutego 1764 roku. Wiadomo, że już w połowie lat osiemdziesiątych jego utwory przepisywane były dla zespołu działającego przy dominikańskim kościele w Gidlach – prawdopodobnie w tym czasie kompozytor też był już aktywny na terenach polskich, pracując jako kapelmistrz w Żarkach oraz dorywczy organista kapeli gidelskiej. W 1789 r. w Żarkach poślubił Klarę Szretter, jednak już dwa lata później był wdowcem, a w 1793 r. ponownie się ożenił, z Joanną Sytniowską (zmarłą w 1797 r. w Koziegłowach).
Na przełomie XVIII i XIX w. centrum życia i aktywności zawodowej Wacława Raszka stała się Warszawa, w której pracował jako nauczyciel fortepianu konwiktu pijarskiego na Żoliborzu (1812–17), prawdopodobnie podejmując też współpracę z Teatrem Narodowym. Być może uczestniczył w muzyce uprawianej przy kościele św. Benona. W 1815 r. ożenił się po raz trzeci z rodowitą warszawianką Elżbietą Lewicką. Po roku urodziło im się pierwsze dziecko, Ludwik Wacław.
W latach 1818 i 1819 odnotowano aktywność muzyka w Opolu Lubelskim, gdzie miał być kapelmistrzem i gdzie urodziła się, a po roku zmarła jego córka Rozalia Kaliksta. Jednak już pod koniec 1819 r. Wacław Raszek przeniósł się do Puław, gdzie został zatrudniony w charakterze dyrektora muzyki w Instytucie Nauczycieli Elementarnych i Organistów. W szkole tej działał aktywnie prawdopodobnie do końca 1825 r., kształcąc kilkudziesięciu chłopców oraz ucząc śpiewu dziewczęta w szkółce parafialnej. Uważano go za sumiennego, pracowitego i odnoszącego sukcesy nauczyciela oraz organizatora życia muzycznego. W Puławach Raszek napisał swoje opus magnum, Kancjonał Muzyki Kościelnej, wydany w Warszawie w 1825 roku. Tam też urodziło się kolejnych dwóch synów kompozytora.
Po opuszczeniu Puław Wacław Raszek powrócił do Warszawy, gdzie współpracował z Archikonfraternią Warszawską oraz dawał prywatne lekcje fortepianu. Zmarł 29 I 1837 r. i został pochowany na Cmentarzu Powązkowskim, a wraz z nim dwójka jego synów, zmarłych odpowiednio sześć i siedem lat po ojcu.
Leaching of Ibute-Nze kaolin iron-oxide impurity with oxalic acid process optimization of dissolution conditions using response surface methodology
Authors: Ochi Daniel O. , Mahmud Hauwau , Ani Marcellinus O. , Aliu Salisu O. 
Published: May 2022

The goal of this research was to remove iron oxide from Ibute-Nze kaolin by dissolving the clay mineral in an aqueous oxalic acid solution and optimizing the process. The chemical composition of the raw and modified clay was determined using x-ray fluorescence, and the morphology of the solid sample was determined using a scanning electron microscope. The best conditions for the oxalic acid leaching of iron-oxides impurity from Ibute-Nze kaolin were determined using response surface methodology based on Box-Behnken design. The studies were carried out within the following process parameter ranges: 40–90 leaching temperature; 0.075-0.355mm particle size; 1–6 mol/dm3 acid concentration; 0.02–0.12 g/cm3 kaolin sample to acid ratio and 30-240 min contact time. The characterization revealed that Ibute-Nze clay is kaolinitic in nature and calcination at 750 opens more pores for its leaching. According to the analysis of variance, a second-order polynomial regression equation provided the best fitting for the experimental data. The predicted and experimental response values were shown to be correlated (R2 = 0.9276) in the experimental runs. The following were found to be the best conditions for the leaching process variables: 83.2051 leaching temperature, 0.0827mm particle size, 3.6179mol/dm3 acid concentration; 0.0287g/cm3 kaolin to acid ratio and 217.932min reaction time. The chemical leaching process was 92.6035 per cent under these conditions, which made the clay good for industrial applications.
HD 183986: A High-contrast SB2 System with a Pulsating Component
Authors: Vaňko Martin , Pribulla Theodor , Gajdoš Pavol , Budaj Ján , Zverko Juraj , Paunzen Ernst , Garai Zoltán , Hambálek Lubomír , Komžík Richard , Kundra Emil 
Published: May 2022

Abstract
There is a small group of peculiar early-type stars on the main sequence that show different rotation velocities from different spectral lines. This inconsistency might be due to the binary nature of these objects. We aim to verify this hypothesis by a more detailed spectroscopic and photometric investigation of one such object: HD 183986. We obtained 151 high- and medium-resolution spectra that covered an anticipated long orbital period. There is clear evidence of the orbital motion of the primary component. We uncovered a very faint and broad spectrum of the secondary component. The corresponding SB2 orbital parameters, and the component spectra, were obtained by Fourier disentangling using the KOREL code. The component spectra were further modeled by iSpec code to arrive at the atmospheric quantities and the projected rotational velocities. We have proven that this object is a binary star with a period P = 1268.2(11) days, eccentricity e = 0.5728(20), and mass ratio q = 0.655. The primary component is a slowly rotating star (

v
sin
i
=
27

km s−1) while the cooler and less massive secondary rotates much faster (

v
sin
i

∼

120 km s−1). Photometric observations obtained by the Transiting Exoplanet Survey Satellite (TESS) satellite were also investigated to shed more light on this object. A multiperiod photometric variability was detected in the TESS data ranging from hours (the δ Sct-type variability) to a few days (spots/rotational variability). The physical parameters of the components and the origin of the photometric variability are discussed in more detail.
Observing Planet-driven Dust Spirals with ALMA
Authors: Speedie Jessica , Booth Richard A. , Dong 董 Ruobing 若冰 
Published: May 2022

Abstract
Atacama Large Millimeter/submillimeter Array (ALMA) continuum observations of thermal emission from the dust component of protoplanetary disks have revealed an abundance of substructures that may be interpreted as evidence for embedded planets, but planet-driven spiral arms—perhaps one of the most compelling lines of evidence—have proven comparatively elusive. In this work, we test the capabilities of ALMA to detect the planet-driven spiral signal in continuum emission. Carrying out hydrodynamic simulations and radiative transfer calculations, we present synthetic Band 7 continuum images for a wide range of disk and observing conditions. We show that thermal mass planets at tens of astronomical units typically drive spirals detectable within a few hours of integration time, and the detectable planet mass may be as low as ∼Neptune mass (0.3 M
th). The grains probed by ALMA form spirals morphologically identical to the underlying gas spiral. The temperature of the dust spiral is crucial in determining its contrast, and spirals are easier to detect in disks with an adiabatic equation of state and longer cooling times. Resolving the spiral is not necessary for its detection; with the help of residual maps, the optimal beam size is a few times the spiral width at a constant noise level. Finally, we show how the presence of gaps and rings can impair our ability to recognize colocated spirals. Our work demonstrates the planet-finding potential of the current design specification of ALMA, and suggests that observing capability is not the bottleneck in searching for spirals induced by thermal mass planets.
Experiments on the Electrostatic Transport of Charged Anorthite Particles under Electron Beam Irradiation
Authors: Gan Hong , Zhang Xiaoping , Li Xiongyao , Jin Hong , Xie Lianghai , Zou Yongliao 
Published: May 2022

Abstract
To reveal the effect of secondary electron emission on the charging properties of a surface covered by micron-sized insulating dust particles and the migration characteristics of these particles, for the first time we used a laser Doppler method to measure the diameters and velocities of micron-sized anorthite particles under electron beam irradiation with an incident energy of 350 eV. Here, anorthite particles are being treated as a proxy for lunar regolith. We experimentally confirm that the vertical transport of anorthite particles is always dominant, although horizontal transport occurs. In our experiments, some anorthite particles were observed to have large vertical velocities up to 9.74 m s−1 at the measurement point. The upper boundary of the vertical velocities V
z of these high-speed anorthite particles are well constrained by its diameter D, that is,

V

z

2

linearly depends on D
−2. These velocity–diameter data provide strong constraints on the dust charging and transportation mechanisms. The shared charge model could not explain the observed velocity–diameter data. Both the isolated charge model and patched charge model appear to require a large dust charging potential of −350 to −78 V to reproduce the observed data. The microstructures of the dusty surface may play an important role in producing this charging potential and in understanding the pulse migration phenomenon observed in our experiment. The presented results and analysis in this paper are helpful for understanding the dust charging and electrostatic transport mechanisms in airless celestial bodies such as the Moon and asteroids in various plasma conditions.
MiMO: Mixture Model for Open Clusters in Color–Magnitude Diagrams
Authors: Li 李 Lu 璐 , Shao 邵 Zhengyi 正义 
Published: May 2022

Abstract
We propose a mixture model of open clusters (OCs) in color–magnitude diagrams (CMDs) to measure the OC properties, including isochrone parameters (age, distance, metallicity, and dust extinction), stellar mass function (MF), and binary parameters (binary fraction and mass-ratio distribution), with high precision and reliability. The model treats an OC in the CMD as a mixture of single and binary member stars and field stars in the same region. The cluster members are modeled using a theoretical stellar model, mass function, and binary properties. The field component is modeled nonparametrically using a separate field-star sample in the vicinity of the cluster. Unlike conventional methods that rely on stringent member selection, ours allows us to use a sample of more complete cluster members and attendant field stars. The larger star sample reduces the statistical error and diminishes the potential bias by retaining more stars that are crucial for age estimation and MF measurement. After validating the method with 1000 mock clusters, we measured the parameters of 10 real OCs using Gaia EDR3 data. The best-fit isochrones are consistent with previous measurements in general but with more precise age estimates for several OCs. The inferred MF slope is −2.7 to −1.6 for clusters younger than 2 Gyr, while older clusters appear to have significantly flatter MFs. The binary fraction is 30%–50%. The photometric and astrometric distances agree well.