bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disassembly of embryonic keratin filaments promotes pancreatic cancer metastases
Authors: Kawalerski Ryan R. , Gonçalves Mariana Torrente , Pan Chun-Hao , Tseng Robert , Roa-Peña Lucia , Leiton Cindy V. , Torre-Healy Luke A. , Boyle Taryn , Chowdhury Sumedha , Snider Natasha T. , Shroyer Kenneth R. , Escobar-Hoyos Luisa F. 
Published: August 2022

AbstractKeratin 17 (K17), an oncofetal intermediate filament protein, is one of the most abundantly expressed proteins in pancreatic ductal adenocarcinomas (PDACs) of the most aggressive molecular subtype. The mechanistic roles of this protein in malignancy, however, are largely unexplored. Here we show that K17 expression and disassembly enhances tumor growth and metastatic potential and shortens survival. Using mass spectrometry in K17 isolated from patient’s tumors, we identified a hotspot phosphorylation site in serines 10-13. Site-mutagenesis revealed that phosphorylation of this hotspot is sufficient to disassemble K17 and promote its nuclear translocation. In silico and pharmacologic inhibition studies uncovered the role of the PKC/MEK/RSK pathway in the phosphorylation and disassembly of K17. Murine models bearing tumors expressing phosphomimetic mutations at the serine hotspot displayed enhanced metastases, compared to mice bearing tumors expressing wild-type K17 or phosphorylation-resistant K17. Lastly, we found that detergent-soluble nuclear K17 promotes the expression of metastasis promoting genes in both patient and murine tumors. These results suggest that phosphorylation at specific serines is sufficient to promote pancreatic cancer metastasis and shorter survival, and that these sites could provide novel, druggable therapeutic domains to enhance PDAC patient survival.
A stimulus-organism-response perspective to examine green hotel patronage intention
Authors: Tan Ling Ling 
Published: August 2022

PurposeThis study aims to investigate the relationships among monetary cost (stimulus), perceived greenwash fear, attitude and perceived behavioural control (organism-related factors) and green hotel patronage intention (response) using the stimulus-organism-response (S-O-R) model.Design/methodology/approachA total of 262 valid questionnaires were collected. Data were collected using the purposive sampling method and tested using the partial least squares (PLS) approach.FindingsMonetary cost is positively related to only one organism-related factor which is perceived greenwash fear. All organism-related factors are positively related to response, which is green hotel patronage intention. Attitude mediates the relationship between perceived greenwash fear and green hotel patronage intention, as well as perceived behavioural control and green hotel patronage intention.Research limitations/implicationsA longitudinal study can be performed in the future to observe the actual green hotel patronage behaviour of customers.Practical implicationsGreen hoteliers should focus on the development of communication strategies to enhance their corporate reputation. Green hoteliers also need to build trust by showing their green initiatives are genuine, identify consumers who are willing to pay more for green hotels and offer promotions with price incentives such as frequency discounts, coupons and rebates to increase interest and trialability.Originality/valueFew studies have focused on the use of monetary cost as a stimulus in the S-O-R model to predict green hotel patronage intention. This study also tested the mediating effect of attitude, one of the organism-related factors, in the model.
Consumers’ perceived value and use intention of cashless payment in the physical distancing context: evidence from an Asian emerging market
Authors: Wang Jianming , Nguyen Ninh , Jiang Xinru (Angie) , Nguyen Hoang Viet , Saleem Muhammad Abid 
Published: August 2022

PurposeCOVID-19 and its measures such as physical distancing have shifted consumer payment behaviors toward cashless payment. Physical distancing is likely to remain a norm for some time to come and will be relevant in any future pandemics. This study aims to examine the impact of consumers’ perceived value of cashless payment on their use intention in the physical distancing context, with the mediating role of psychological safety and the moderating role of trust propensity.Design/methodology/approachThis study used a survey method to obtain data from 690 consumers in an Asian emerging market, i.e. Vietnam. The data were analyzed using different statistical methods, including structural equation modeling.FindingsResults show that perceived value of cashless payment positively affects use intention, and this effect is mediated by psychological safety. Furthermore, trust propensity has a positive moderating effect on the link between perceived value and psychological safety.Practical implicationsThis study’s findings provide implications for retailers and other stakeholders in implementing and promoting cashless payment systems, especially in the physical distancing context.Originality/valueThis study is among the first attempt to explain the relationships between consumers’ perceptions, feelings of psychological safety and use intention toward cashless payment in the physical distancing context. The study’s findings may also be relevant to any future pandemics.
Behind the “specialty”: personal values that influence the behavior of specialty coffee consumers
Authors: Giovane da Silva Marcos , Vilas Boas Luiz Henrique de Barros , Teodoro Alberdan José da Silva 
Published: August 2022

PurposeThis study aimed to describe the cognitive associations existing among specialty coffee consumers through the means-end chain theory and personal values.Design/methodology/approachThe research follows a descriptive qualitative study that used in-depth interviews and laddering, to collect data among 40 interviews with regular consumers of specialty coffees in Brazil. The interviews were transcribed, and from the content analysis, the attributes, consequences and values that emerged in the discourse of consumers of specialty coffees were found. The categories were later classified – according to the level of abstraction – and inserted into the LadderUx® software to generate the implication matrix and the hierarchical map of values. The interpretation of results occurred in a descriptive way.FindingsBased on a hierarchical value map, the following personal values were identified: universalism, self-directed action, accomplishment, tradition and personal security. These values can be considered guides for consumption behavior. They are also related to consumption behavior that values technical attributes, such as roast level, packaging, aroma and flavor, and the relationships between these values and personal improvement, social relationships and recognition are relevant factors involved in decision-making.Originality/valueThis study presents the cognitive structure of Brazilian specialty coffee consumers. The coherent use of this information enhances the development of marketing actions involving communication actions, relationships with internal and external customers, new farm management strategies, direct trade with consumers and sustainable improvements in the production chain. These are the factors that can motivate the purchase of food, thus attracting new consumers to this emerging market.
Smart manufacturing and sustainability: a bibliometric analysis
Authors: Tiwari Saurabh , Bahuguna Prakash Chandra , Srivastava Rajeev 
Published: August 2022

PurposeDuring the past decade, the necessity to integrate manufacturing and sustainability has increased mainly to reduce the adverse effect on the manufacturing industry, transforming traditional manufacturing into smart manufacturing by adopting the latest manufacturing technology as part of the Industry 4.0 revolution. Smart manufacturing has piqued the interest of both academics and industry. Manufacturing is a foundation of products and services required for human health, safety, and well-being in modern society and from an organizational standpoint. This paper uses bibliometric analysis better to understand the relationship between smart manufacturing and sustainability scholarship and provide an up-to-date account of current industry practices.Design/methodology/approachThis paper used the bibliometric analysis method to analyze and draw conclusions from 839 articles retrieved from the Scopus database from 1994 to February 2022. The methodology is divided into four steps: data collection, analysis, visualization, and interpretation. The current study aims to comprehend smart manufacturing and sustainability scholarship using the bibliometric R-package and VOSviewer software.FindingsThe study provides fascinating insights that may assist scholars, industry professionals, and top management in conceptualizing smart manufacturing and sustainability in their organizations. The results show that the number of publications has significantly increased from 2015 onwards, reaching a maximum of 317 journals in 2021 with an increasing publication annual growth rate of 21.9%. The United Kingdom, India, the United States of America, Italy, France, Brazil and China were the most productive countries in terms of the total number of publications. Technological Forecasting and Social Change, Journal of Cleaner Production, International Journal of Production Research, Production Planning and Control, Business Strategy and the Environment Technology in Society, and Benchmarking: An International Journal emerged as the top outlets.Research limitations/implicationsThe research in the area of smart manufacturing and sustainability is underpinned by this study, which aims to understand the trends in this field over the last two decades in terms of prolific authors, most influential journals, key themes, and the field's intellectual and social structure. However, according to the research, this field is still in its early stages of development. As a result, a more in-depth analysis is required to aid in the development of a better understanding of this new field.Originality/valueThe paper focuses on integrating smart manufacturing and sustainability through increased interest from 2015 onwards through the literature review. Specific policies should be formulated to improve the manufacturing sector's competence. Furthermore, these findings can guide researchers who want to delve deeper into smart manufacturing and sustainability.
Can qualitative job insecurity instigate workplace incivility? The moderating roles of self-compassion and rumination
Authors: Qian Shanshan , Lim Vivien K.G. , Gao Yongduan 
Published: August 2022

PurposeThis study examines why and when qualitative job insecurity (JI) leads to instigated workplace incivility.Design/methodology/approachThe authors collected data from 227 Chinese full-time employees from multiple organizations at two time points. Structural equation modeling was used to test hypotheses.FindingsResults show that qualitative JI is positively related to instigated workplace incivility through negative emotions; this indirect relationship is weaker among employees with higher self-compassion and stronger among employees with higher rumination.Originality/valueThe authors shift the predominant focus on the predictor of instigated workplace incivility from quantitative JI to qualitative JI. Based on the transactional model of stress and the stressor–emotion model of counterproductive work behavior (CWB), they provide new theoretical insights on why qualitative JI affects workplace incivility and identify new boundary conditions that affect employees' reactions to qualitative JI.
Regime shifts in a long-run risks model of stock and treasury bond markets
Authors: Li Kai , Xu Chenjie 
Published: August 2022

PurposeThis paper aims to study the asset pricing implications for stock and bond markets in a long-run risks (LRR) model with regime shifts. This general equilibrium framework can not only generate sign-switching stock-bond correlations and bond risk premium, but also quantitatively reproduce various other salient empirical features in stock and bond markets, including time-varying equity and bond return premia, regime shifts in real and nominal yield curves, the violation of the expectations hypothesis of bond returns.Design/methodology/approachThe researchers study the joint determinants of stock and bond returns in a LRR model framework with regime shifts in consumption and inflation dynamics. In particular, the means, volatilities, and the correlation structure between consumption growth and inflation are regime-dependent.FindingsThe model shows that the term structure of interest rates and stock-bond correlation are intimately related to business cycles, while LRR play a more important role in accounting for high equity premium than do business cycle risks.Originality/valueThis paper studies the joint determinants of stock and bond returns in a Bansal and Yaron (2004) type of LRR framework. This rational expectations general equilibrium framework can (1) jointly match the dynamics of consumption, inflation and cash flow; (2) generate time-varying and sign-switching stock and bond correlations, as well as generating sign-switching bond risk premium; and (3) coherently explain another long list of salient empirical features in stock and bond markets, including time-varying equity and bond return premia, regime shifts in real and nominal yield curves, the violation of the expectations hypothesis of bond returns.
Safety tag generation and training material recommendation for construction workers: a persona-based approach
Authors: Duan Pinsheng , Zhou Jianliang , Fan Wenhan 
Published: August 2022

PurposeEffective construction safety training has been considered to play a significant role in reducing the incidence of accidents. However, the current safety training methods pay less attention to the relationship between workers' personalized characteristics and their learning needs, which results in workers' low learning participation and poor training effect. The purpose of this paper is to improve the participation and effect of safety training for construction workers with a persona-based approach.Design/methodology/approachThis paper presents a persona-based approach to safety tag generation and training material recommendation. By extracting the demographic characteristics and behavior patterns tags of construction workers, a neural network algorithm is introduced to calculate the learning needs tags of workers, and the collaborative filtering recommendation method is integrated to enrich the innovation of recommendation results. Offline experiments and online experiments are designed to verify the rationality of the proposed method.FindingsThe results show that the learning needs of workers are closely related to their background. The proposed method can effectively improve workers' interest in materials and the training effect compared with conventional safety training methods. The research provides a theoretical and practical reference for promoting active safety management and achieving worker-centered safety management.Originality/valueFirst, a persona-based approach is introduced to establish a novel framework for solving the problem of personalized construction safety management. Second, an artificial intelligence algorithm is used to automatically extract the learning needs tag values and design a hybrid recommendation method for construction workers' personalized safety training. The collaborative filtering method is integrated to enrich the innovation of recommendation results.
Industrial attachment and human capital of higher education students: constraints of Ghanaian technical universities
Authors: Nunfam Victor Fannam , Adjei Norbert Adja Kwabena , Adam Hafiz , Eshun John Frank 
Published: August 2022

PurposeThe paucity of empirical evidence on the limitations of the industrial attachment programme of technical universities for enhancing students' human capital in Africa tends to thwart concrete policy options.Design/methodology/approachThe study used the convergent mixed methods including 594 surveys, two focus groups and in-depth interviews to assess and accentuate the research gap in this study.FindingsEvidence of constraints linked to the industrial attachment programme for developing students' human capital needs include limited funding, logistics and incentive for supervision, incompatible placement and exploitation and sexual harassment of students. Insufficient duration and intrusion of the industrial attachment programme due to labour unrests, inadequate collaboration and fears of student interns breaching organisations' confidentiality policies were also found to hinder the programme.Research limitations/implicationsThe study's dependence on participants' perspectives has the possibility of being characterised by recollection prejudice. The comparatively limited scope and size of the study participants creates concerns of representativeness and generalisability of the study outcome.Practical implicationsThe outcome of this study could yield significant practical implications for the planning and operations of the industrial attachment programme of tertiary institutions. It also provides information which could serve as the basis for future research and comprehensive evaluation of the programme's planning and implementation.Originality/valueThe authors have delineated empirical evidence on the constraints of the industrial attachment programme of Ghanaian technical universities to inform policy decisions on the planning, operations, funding and evaluation of the programme in collaboration with industry and government.
Factors of dropout from MOOCs: a bibliometric review
Authors: Wang Wei , Zhao Yongyong , Wu Yenchun Jim , Goh Mark 
Published: August 2022

PurposeAlthough MOOCs have become a pervasive online learning model, the problem of high dropout rates still persists. Gathering the reasons for the high dropout rate can help to improve the platform design and management of the MOOCs.Design/methodology/approachA total of 74 studies was extracted from the Web of Science and Scopus. Following the PRISMA (Preferred Reporting Items for systematic Reviews and Meta-Analyses) guidelines, the open-source program CiteSpace is employed to review and induce the studies on the antecedents of MOOC dropout.FindingsThe antecedents of the MOOC dropout rate are the psychological, social, personal, course-related, and time factors, and the unexpected hidden cost. Motivation and interaction, which have a decisive impact on the dropout rate of MOOCs, interact with each other. Interaction helps to strengthen the motivation, and appropriate course design enhances the degree of interaction.Originality/valueFrom the perspective of a learner, the more knowledge and skills the learners acquire, the more likely they will complete the course. Possessing adequate foundational knowledge is one way to arrest the dropout rate. On the part of the MOOC platform, better course design eases the dropout rate. Further, the course duration and hidden cost in MOOCs contribute to the dropout rate.
Value co-creation as a mediator between strategic planning and social enterprise performance
Authors: Mathibe Motshedisi Sina , Chinyamurindi Willie Tafadzwa , Hove-Sibanda Progress 
Published: August 2022

Purpose
The purpose of this study is twofold. The first was to explore the relationship between strategic planning (SP) and social enterprise performance (SEP). The second was to ascertain the mediation of value co-creation (VCC) to the relationship between SP and SEP.

Design/methodology/approach
This study followed a quantitative methodology using a survey conducted with 147 social enterprises (SEs). The location of the study was the Eastern Cape, a province in South Africa. Respondents to the study occupied the status of key decision-makers who either owned or managed a SE.

Findings
The findings show that a relationship exists between SP and VCC; VCC and SEP; and finally SP and SEP. Concerning the mediation, results show that VCC had a fairly weak positive and significant mediating effect on the relationship between SP and enterprise performance.

Originality/value
There are renewed calls for research that focuses on understanding issues related to the management of SEs, especially within the South African context. Such calls stem from the high dependence on state support to alleviate challenges experienced by communities. The role of SEs in such a context is thus heightened. The findings give support to issues that assist not only in understanding the decision-making capability but also in understanding the role of VCC.
Tropical whites: Hegemonic masculinity and menswear at the crossroads of Australia and Asia, 1900–1939
Authors: Bellanta Melissa , Cramer Lorinda 
Published: August 2022

AbstractThis article explores the social and gender history of ‘tropical whites’ – all‐white men's suits worn with pith helmets in tropical societies colonised by European powers – between c.1900 and 1939. Focusing on two northern Australian ports with multiple connections to Asia, the article shows that tropical whites helped to sustain inequities of race, gender and class in the colonial tropics. The fashion did this by helping to produce hegemonic masculinity in the region. Tropical whites served this function by symbolising racial whiteness and imperial mastery, but also because of their material dimensions: who made and maintained them, and the bodily influence they exerted on their wearers. Underlining the embodied dimensions of hegemonic masculinity, the article explores the multidimensional relationship between menswear and power in the Australian tropics; at the same time showing that racially subordinated men transformed aspects of the fashion for their own ends.
Provider discussion of health goals and psychosocial needs: Comparing older to younger veteran experience
Authors: Cogan Alison M. , Saliba Debra , Steers W. Neil , Frochen Stephen , Lynch Kimberly A. , Ganz David A. , Washington Donna L. 
Published: August 2022

AbstractObjectiveTo examine by age, the veterans' report on whether components of age‐friendly health systems were discussed during primary care visits.Data Sources and Study SettingVeterans Affairs (VA) Survey of Healthcare Experience of Patients from October 2015 to September 2019.Study DesignCross‐sectional survey of VA users by age group (18–44 years, 45–64 years, 65+ years; N = 1,042,318). We used weighted logistic regression models to evaluate disparities in whether veterans discussed with anyone in their provider's office: health goals, depression symptoms, stress, personal problems, and medications. Models were adjusted for socio‐demographic characteristics (sex, socioeconomic status, education, rurality) and comorbidity.Data Collection/Extraction MethodSurveys were administered by mail and online. Additional veteran characteristics were extracted from VA administrative data.Principal FindingsIn unadjusted analyses, VA users age 18–44 had a higher (−8.2%; CI: −9.0, −7.3) and users aged 45 to 64 had lower (4.0%; CI: 3.7, 4.3) predicted, probably discussing health goals compared to age 65+. Fewer VA users age 65+ reported discussing depression symptoms, personal problems, and stress than other age groups, whereas more VA users age 65+ discussed medications. Results were unchanged after adjusting for socio‐demographics and comorbidity.ConclusionsDelivery of goal‐concordant care relies on understanding the needs of individual patients. Lower rates of discussing what matters and mood represent potential missed opportunities to deliver age‐friendly care for older veterans.