bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Lingkungan Kerja, Motivasi dan Efikasi Diri Terhadap Kinerja Karyawan Pada CV. Pesona Sakti Bangkalan Di Masa Pandemi Covid-19
Authors: Rosid Abd. , Irawati S Anugrahini 
Published: October 2022

CV. Pesona Sakti is a company in construction services. It has a very tight competition, CV. Pesona Sakti has had commitment and powerd by improving the employees performance. This study analyzes the effect of the work environment, motivation, and selfefficacy on employees performance during the covid-19 pandemic. The independent variables are work environment, motivation and self-efficacy and the dependent variable is employees performance. The data collection method uses a questionnaires and the data analyzes using multiple linear regression. The results indicate that the work environment has a positive and significant effect on the employees performance with a value is 2.517 and the significance value is 0.015 0.05. Motivation has a positive and significant effect on the employees performance with a value is 4.120 and the significance value ois 0.000 0.05. Self-efficacy has a positive and significant effect on employees performance with a value is 2.109 and the significance value is 0.040 0.05. Simultaneously, the work environment, motivation, and self-efficacy have a positive and significant effect on the employees performance with a value is 44,4692.81 and the significance value is 0.0000.05.
High-throughput image-based drug screening of Caenorhabditis elegans movement, development, and viability
Authors: Gallo Kendra , Zamanian Mostafa 
Published: October 2022

Abstract
Caenorhabdtis elegans is an important model organism for identifying and studying druggable targets in a high-throughput manner [1–3]. We have previously described a modular pipeline for image processing and analysis for both parasitic and free-living worms [4]. Here, we detail the upstream assay set up for high throughput drug screens of the free-living nematode C. elegans.
Following a standard bleaching protocol, embryos are hatched overnight and synchronized L1s are added to a 96-well plate. Concentrated Esherichia coli strain HB101 bacterial food [5] is added to each well to sustain growth for 48 hours along with compounds of interest. Plates are incubated for 48 hours until worms reach the young adult stage. While this assay has been optimized for image acquisition with an ImageXpress high-content imager, it can be adapted for use on similar imaging platforms. Analysis of images from an ImageXpress is seamless using wrmXpress [4], but other analysis software can be used.
Pesudo-capsulated Hepatocellular Carcinoma: Hepatic Arterial Infusion Chemotherapy versus Transcatheter Arteial Chemoembolization
Authors: An Chao , Yao Wang , Zuo Mengxuan , Li Wang , Chen Qifeng , Wu Peihong 
Published: October 2022

Abstract
Background
The effectiveness and safety of hepatic arterial infusion chemotherapy (HAIC) or trans-arterial chemoembolization (TACE) for cases with single pseudo-capsuled hepatocellular carcinoma (pHCC), as well as their survival outcomes were investigated.
Methods
196 cases with single pHCC (diameter > 5 cm) receiving initial HAIC (n = 92) and TACE (n = 104) were enrolled. The propensity score match (PSM) approach based on Cox models was employed to tune any possible imbalance in treatment assignment. The overall survival (OS), objective response rate (ORR), progression-free survival (PFS), and partial response rate (PRR) of the subjects were investigated by using the Log-rank test. The independent risk factors for outcomes were investigated by univariate and multivariate analyses and the results were analyzed by using the Cox regression model.
Results
The median follow-up of the subjects was 22.3 months. After PSM, no significant difference was found in OS of the HAIC and TACE groups (OS, 16.8 vs. 12.0 months; P = 0.267), while the median PFS of the TACE group was enhanced compared with the HAIC group (PFS, 5.7 vs. 2.8 months; P = 0.003). Moreover, PRR and ORR of the TACE group were enhanced compared with the HAIC group (PRR, 34.6% vs. 21.7%; P = 0.046; ORR, 35.6% vs. 21.7%; P = 0.033). The nomogram model showed high predictive accuracy and significant discrimination.
Conclusions
TACE therapy could improve the control of tumor progression compared with HAIC for cases with single pHCC.
Dissecting the novel molecular interactions of solute carrier family 4 member 4 (SLC4A4) for prostate cancer (PCa) progression
Authors: Rashid Asif , Fung Hiu Ling , Tang Alexander Hin Ning 
Published: October 2022

Abstract

Prostate cancer (PCa) is the most common malignancy diagnosed in men. The purpose of this study was to report the mechanistic pathways of SLC4A4 in the progression of PCa. Here, we report our findings from clinical specimens of prostatic acinar adenocarcinoma collected from patients. We found that low grade prostate cancers have higher SLC4A4 expression compared to high grade cancers. We investigate the role of SLC4A4 and the signaling mechanism underlying its role in modulating the PCa progression. We report the SLC4A4/RB axis, which acts to drive the cell proliferation. SLC4A4 knockdown decreases the interaction between these molecules with hypophosphorylation of RB protein and cell cycle arrest. We also investigate the SLC4A4/GSK-3β/β-catenin signaling axis which regulates the clonogenic potential, invasiveness and metastasis. Functional analysis reveals that SLC4A4 knockdown retards tumor growth and lower the invasion and migration potential. This is related to relieve of the GSK-3β activity, which phosphorylates β-catenin at Ser33/37 with reduction of β-catenin level in PCa cells. Likewise, transcriptome sequencing using the SLC4A4 knockdown in DU145 shows regulation of differentiated expressed genes and multiple metabolic pathways. Our results suggest that SLC4A4 may serve as a potential therapeutic target for prostate cancer patients in the future.
Partial-convolution-implemented generative adversarial network (GAN) for global oceanic data assimilation
Authors: Ham Yoo-Geun , Joo Yong-Sik , Kim Jeong-Hwan , Kim Kang-Min , Lee Jeong-Gil 
Published: October 2022

Abstract

The oceanic data assimilation (DA) system, which interpolates the sparse observations to regular grids based on physical knowledge implemented in a numerical model, is indispensable to understand and forecast the global oceanic climate variabilities. Here we developed a deep-learning-based global oceanic DA system—DeepDA—by incorporating a partial convolutional neural network and a generative adversarial network (GAN). The partial convolution acts as an observation operator that projects the irregular observational information on gridded fields, and the GAN model brings in the observational information from previous time frames. Observing system simulation experiments showed that the analysis error in the DeepDA-produced three-dimensional temperature is systematically reduced compared to both the background and observed values. The DeepDA global temperature reanalysis for 1980-2020 successfully reconstructed the observed global climatological fields, seasonal cycle, and the dominant oceanic temperature variabilities. The DeepDA, which was formulated solely with a long-term control simulation, successfully lowers the technical barrier in obtaining global ocean reanalysis datasets using physical constraints in various numerical models, and thus, reduces the systematic uncertainties in estimating decades of global oceanic states using these models.
‘Harnessing the power of the law’: a qualitative analysis of the legal determinants of health in English urban planning and recommendations for fairer and healthier decision-making
Authors: Montel Lisa 
Published: October 2022

Abstract
Background: Urban environments impact negatively on the risks of non-communicable diseases and perpetuate health inequalities. Against this, law could play a critical role, notably through implementing and securing visions of health and well-being, and evidence-based interventions.
Methods: Seven teams conducted 123 interviews with 132 actors in urban planning in England. Teams had expertise in urban planning, transport, real estate, public health, public policy, administration, and management. An additional team with expertise in law analysed data from all interviews to explore how the law is perceived and used to promote health in urban planning.
Results: Six issues were identified as preventing actors from using the law to improve health in urban planning: i) density and complexity of the law; ii) weak and outdated regulatory standards; iii) absence of health from legal requirements in the decision-making process; iv) inconsistent interpretations by actors with competing interests; v) lack of strong health evidence-based local planning policies; and vi) inertia of the law.
Conclusions: The legal determinants of health listed in the Lancet-O’Neill Commission’s report need to be strengthened at the local level to effectively deploy law in English urban development. The findings call for strong, evidence-based local planning policies and decision-making frameworks, placing health as (one of the) core value(s) of urban planning and showing what types of development benefit health, i.e., prevent NCDs risks and reduce health inequalities on the long term. The legal capacity of local government should be strengthened to empower decision-makers in shaping urban development that promotes health for everyone.
Protein-Ligand Based Pharmacophore Approach against ERK5 Involved in Breast Cancer; In-Silico Study of Flavonoids from Blighia sapida
Authors: Bodun Damilola , Omoboyowa Damilola , Adedara Joshua F , Olugbogi Ezekiel , Atasie Nkechi , Oluwafemi Isaac 
Published: October 2022

Abstract
Conclusions: Flavonoids from B. sapida may serve as promising inhibitors of ERK5 for breast cancer management.
Background: Breast cancer is a global public health issue that can be caused by environmental or hereditary factors. There are still a shortage of effective treatments with enhanced efficacy and acceptability against the disease, as many breast cancer drugs have serious side effects. Hence, the inhibitory potential of flavonoids from Blighia sapida against breast cancer target (ERK5) was investigated.
The interactions of the target protein and its co-crystallized ligand were used to develop a protein-ligand based pharmacophore hypothesis. The idea was applied to the screening of phytochemicals obtained from an online database. Following that, we used structural bioinformatics and theoretical chemistry tools to find new ERK5 inhibitors using molecular docking, molecular mechanics generalized Born surface area (MM-GBSA) and pharmacokinetics model in Schrödinger suite, density functional theory analysis (DFT) was also performed using Spartan 10.
Results: The technique discovered new lead molecules as inhibitors of ERK5 as breast cancer therapy through molecular docking and MM/GBSA calculation with Quercetin, Kaempferol and (+)-Catechin showing higher docking score than the co-cystalized ligand and the standard drug. In the phase-generated E-pharmacophore theory, the postulated pharmacophore hypothesis has a hydrogen bond acceptor, hydrogen bond donor, and aromatic ring. Interestingly, all the hits obeyed Lipinski rule of five. The results of the frontier molecular orbitals revealed that the EHOMO values of the hit compounds range from -6.02 to -5.48 eV indicating that all the hit compounds will readily donate electron.
Conclusions: Flavonoids from B. sapida may serve as promising inhibitors of ERK5 for breast cancer management.
Revisiting Fertility Regulation in Tunisia
Authors: Frini Olfa , Muller Christophe 
Published: October 2022

Abstract
Background
In this paper we revisit fertility regulation in Tunisia. As marriage is the exclusive acknowledged childbearing context, we reconsider fertility analysis in Tunisia by examining family influence through the sequence: woman’s marriage age, post-marriage delay in the first use of contraception, and past and current contraceptive use.
Methods
Using data from the 2001 PAP-FAM Tunisian survey, we estimate duration and probability models of these birth control decisions.
Results
The significant effects of covariates are found to arise and vanish as women progress in their lifecycle and along changes in the family planning policies. Family links and socio-cultural environment appear to greatly shape fertility regulation.
Conclusion
This calls for family planning policies that address more the extended families.
Capsaicin ameliorates fatty accumulation both in mouse liver and in human hepatocytes
Authors: Gao Jing , Wang Shuqin , Li Xue , Xiao Leming , Jia Xiaoyuan , Ai Wen , Zhou Yanrong , Ye Ting , Chen Kan 
Published: October 2022

Abstract
Background:Nonalcoholic fatty liver disease (NAFLD) is a continuous spectrum of the disease recognized as excessive fatty accumulation in the liver, and no effective drugs are approved by FDA. Present study aimed to investigate whether capsaicin, the major ingredients of pepper, can ameliorate the progression of NAFLD. The underlying mechanism was also explored.
Methods:The function of capsaicin on lipid accumulation was assessed both in high-fat high-sugar diet (HFHSD) induced mice and in human hepatocytes. In animal experiments, mice were divided into three groups: normal diet (ND), HFHSD, and HFHSD subjected to capsaicin cream. The body weight, liver weight, lipid droplets, triglyceride (TG), and total cholesterol (TC) of each group were compared. In cell experiments, WRL68 cells were cultured with the palmitic and oleic acid (PAOA) mixture. The lipid accumulation was detected using fluorescence microscopy and flow cytometer. RT-qPCRwas performed to explore the potential mechanism of capsaicin.
Results: Topical application of capsaicin significantly decreased liver index (HFHSD vs HFHSD + Cap, 6.92 ± 1.47 vs 6.16 ± 1.13, mean ± SEM, n = 8) and ameliorated hepatic fatty accumulation (HFHSD vs HFHSD + Cap, 22.54 ± 4.53 vs 9.92 ± 4.42, mean ± SEM, n = 8) in HFHSD-fed mice. Capsaicin treatment decreased intracellular lipid accumulation in human hepatocytes. RT-qPCR showed that HFHSD feeding or PAOA exposure could significantly up-regulate the levels of SREBP-1c, ACC1, and CYP2E1, while capsaicin application reversed their expression.
Conclusion: Topical application of capsaicin ameliorates fatty accumulation both in mice and human hepatocytes, which may be related to de novo lipogenesis inhibition and ω-oxidation regulation.
Effect of probiotic supplementation on lipoprotein-associated phospholipase A2 in type 2 diabetic patients: a randomized double-blind clinical controlled trial
Authors: Jaff Salman , Gubari Mohammed , Shab-Bidar Sakineh , Djafarian Kurosh 
Published: October 2022

Abstract
Background: It has been recently reported that lipoprotein-associated phospholipase A2 (Lp-PLA2) may predict the risk of cardiovascular disease. The effect of multi-strain probiotics on Lp-PLA2 in patients with type 2 diabetes is still not clear. This study aimed to determine the effect of multi-strain probiotic supplementation on lipoprotein-associated phospholipase A2, and glycemic status, lipid profile, and body composition in patients with type 2 diabetes.
Methods: In this randomized double-blind placebo-controlled clinical trial, 68 participants with type 2 diabetes, in the age group of 50-65 years, were recruited and randomly allocated to take either probiotic (n= 34) or placebo (n= 34) for 12 weeks. The primary outcome was lipoprotein-associated phospholipase A2, and secondary outcomes were glycemic parameters, lipid profile, anthropometric characters, and body composition (fat mass and fat-free mass).
Results: There was a significant reduction in serum lipoprotein-associated phospholipase A2, in the probiotic group, it dropped by 6.4 units at the end of the study (p <0.001) compared to the placebo group. Probiotic supplementation also resulted in a significant improvements in the hemoglobin A1c and high-density lipoprotein cholesterol 1.5% (p <0.001) and 6 mg/dl (p 0.005). There were no significant changes in other outcomes.
Conclusion: We showed that probiotic supplementation was beneficial for reducing Lp-PLA2 and hemoglobin A1c and improving high-density lipoprotein cholesterol which may suggest an improvement in the prognosis in patients with type 2 diabetes.
Towards an Efficient, Privacy-aware Federated Learning Scheme
Authors: Alekszejenkó Levente , Dobrowiecki Tadeusz 
Published: October 2022

Abstract
With the rapid evolution of Internet-of-Things (IoT) devices and the emergence of Autonomous Vehicles (AVs), machine learning processes pose a growing privacy issue. Federated learning (FL) and current cryptography can mitigate this problem; however, these solutions might not be efficient enough during the decades-long lifespans of such gadgets.
In this paper, a generalization of FL schemes, incorporating sharing a part of raw data, is presented with a proof-of-concept experiment. Besides anonymization, the exchanged data portion can also directly support real-time decision-making. In contrast with cryptographical approaches, the proposed FL scheme can guarantee a certain level of privacy during the whole lifetime of IoT devices or AVs.
Monolithic Integration of Embedded III-V Lasers on SOI
Authors: Wang Ting , Wei Wen-Qi , He An , Yang Bo , Wang Zihao , Huang Jingzhi , Han Dong , Ming Ming , Guo Xuhan , Su Yikai , Zhang Jianjun 
Published: October 2022

Abstract
Silicon photonic integration has gained great success in many application fields owing to the excellent optical device properties and complementary metal-oxide semiconductor (CMOS) compatibility. Realizing monolithic integration of III-V lasers and silicon photonic components on single silicon wafer is recognized as a long-standing obstacle for ultra-dense photonic integration, which can provide considerable economical, energy efficient and foundry-scalable on-chip light sources, that has not been reported yet. Here, we demonstrate embedded InAs/GaAs quantum dot (QD) lasers directly grown on trenched silicon-on-insulator (SOI) substrate, enabling monolithic integration with butt-coupled silicon waveguides. By utilizing the patterned grating structures inside pre-defined SOI trenches and unique epitaxial method via hybrid molecular beam epitaxy (MBE), high-performance embedded InAs QD lasers with monolithically out-coupled silicon waveguide are achieved on such template. By resolving the epitaxy and fabrication challenges in such monolithic integrated architecture, embedded III-V lasers on SOI with continuous-wave lasing up to 85 oC are obtained. The maximum output power of 6.8 mW can be measured from the end tip of the butt-coupled silicon waveguides, with estimated coupling efficiency of approximately -7.35 dB. The results presented here provide a scalable and low-cost epitaxial method for realization of on-chip light sources directly coupling to the silicon photonic components for future high-density photonic integration.
Clinical predictors of surgical intervention for gastrointestinal magnetic foreign bodies in children
Authors: Zhang Ruiyun , Cai Peng , Zhang Tingting , Zhu Jie , Chen Jianlei , Zhao Haowei , Jiang Yuliang , Wang Qi , Zhu Menglei , Zhou Xiaogang , Xiang Xianlan , Hu Feilong , Gu Zhicheng , Zhu Zhenwei 
Published: October 2022

Abstract
Background/Aims: To investigate the clinical situation, treatment methods, and clinical predictors of surgical intervention in children with magnetic foreign bodies in the digestive tract.
Materials and Methods: From January 2019 to June 2022, we retrospectively analyzed the clinical data of 72 children who ingested magnetic foreign bodies inadvertently in our hospital, including their general information, admissions, clinical manifestations, and treatment methods, as well as pertinent literature and statistical data. Following software processing, univariate and multivariate logistic regression analyses were conducted to determine the independent risk factors of this study, and the receiver operating characteristic curve (ROC) was used to evaluate their predictive performance.
Results: Among the 72 children who accidentally ingested magnetic foreign bodies, 59 (86.8%) ingested foreign bodies, with an average of 3.42 days and 11.03 foreign bodies. The predominant symptoms were nausea and vomiting. 19 cases (31.2%), 33 cases (54.1%) with abdominal pain; 9 cases (14.8%) with peritoneal irritation; 13 cases (21.3%) within 24 hours with foreign body movement. Treatment: conservative in 16 cases (22.2%), gastroscope in 19 cases (26.4%), and surgery in 37 cases (51.4%), with gastrointestinal perforation occurring in 26 cases (70.3%). ROC (AUC = 0.808) for predicting surgical treatment plans for children with magnetic foreign body ingestion.
Conclusion: We found that nausea、vomiting and intermittent abdominal pain significantly increased the likelihood of surgical treatment in children undergoing surgery.
Transcriptome and metabolome reveal key genes in the phenylpropane pathway to regulate the floral fragrance of Rhododendron fortunei
Authors: Yang Guoxia , Yi Qin , Yonghong Jia , Xiaohong Xie , Dongbin Li , Baoxin Jiang , Qu Wang , Siyu Feng , Yueyan Wu 
Published: October 2022

Abstract
Background: Floral aroma is an important plant trait and it is one of the main traits of Rhododendron varieties which affect their ornamental value. The volatile compounds of floral aroma are secondary metabolites. In order to reveal the key genes of the phenylpropane pathway, which regulates the fragrance of Rhododendron fortunei, we performed a comprehensive transcriptome and metabolome analysis of the petals of the petals of two alpine rhododendrons from two different varieties: the scented Rhododendron fortunei and the non-scented Rhododendron ‘Nova Zembla’.
Results: Transcriptomic and qRT-PCR results showed that nine candidate genes were highly expressed in R. fortunei, but down-regulated in R. ‘Nova Zembla’. The correlation analysis of candidate genes and metabolites revealed nine key genes involved in the regulation of floral aroma in the phenylpropane pathway. Among them, EGS was significantly positively correlated with various volatile benzene/phenylpropane compounds, and significantly negatively correlated with various non-volatile compounds; CCoAOMT, PAL, C4H,and BALDH were significantly negatively correlated with various volatile benzene/phenylpropane compounds, and significantly positively correlated with various non-volatile compounds. CCR, CAD, 4CL, and EGSwere significantly negatively correlated with various benzene/phenylpropane compounds. The validation of RfSAMT proved that RfSAMT gene regulated the synthesis of aromatic substances in R. fortunei.
Conclusion: The findings of this study indicated that key candidate genes and metabolites involved in the biosynthetic pathway of phenylpropane may regulate the fragrance of R. fortunei. This lays a foundation for further research on the molecular mechanism of fragrance synthesis in the genus Rhododendron.