bluuebunny/crossref_metadata_2025_split huggingface dataset:
Students’ Motivation in Offline Learning Post Covid-19
Authors: Syakir Akhmad Syakir , Rizki Nurwahyuni  
Published: September 2022

Abstract: The return of the education system to face-to-face learning had an impact on students' learning habits. This study aimed to perceive the students’ intrinsic motivation in offline learning post-COVID-19. It focused on instrumental motivation. The subjects of this study included 25 new students from Canada's group of Intensive English Classes at the University of Muhammadiyah Banjarmasin toward their offline learning post-Covid-19. Observations and questionnaires were used to analyze the data in a descriptive qualitative manner. The mean score of the students' intrinsic motivation was discovered to 71,3. It means that the students in the Intensive English Class have an intermediate intrinsic motivation for learning English.

Keywords: Students’ motivation, intrinsic, offline learning.
The Analogy of Magnet Rules to Practice Main Verbs and Helping Verbs in English Sentence Predicate
Authors: Suciati Nana , Palupi Tri Winindyasari 
Published: September 2022

The rule of magnet is the basic condition of every magnet. It has north and south poles. When the north pole of one magnet is closed to the south pole of another magnet, they will pull each other. On the opposite, when north pole is closed to north pole, or south pole is closed to south pole, they will repel each other. These basic rules of magnet can be applied to help students to understand developing English sentence predicate, especially when the sentences are the result of translation from Bahasa Indonesia. The translation result is sometimes not accepted grammatically. It seems that our students still making mistakes when it comes to use helping verbs and main verbs in their sentences. This study is to propose the option of using magnet rules as a teaching trick to help students making sentences in English grammatically by using analogy of magnet rules for main verbs and helping verbs in English.
Surgical treatment strategies for patients with type A aortic dissection involving arch anomalies
Authors: Zhu Jiade , Tong Guang , Zhuang Donglin , Yang Yongchao , Liang Zhichao , Liu Yaorong , Yu Changjiang , Zhang Zhen , Chen ZeRui , Liu Jie , Yang Jue , Li Xin , Fan Ruixin , Sun Tucheng , Wu Jinlin 
Published: September 2022

ObjectiveThe aim of the study was to investigate surgical modalities and outcomes in patients with type A aortic dissection involving arch anomalies.MethodPatients with type A aortic dissection who underwent surgical treatment at our center between January 2017 and 31 December 2020 were selected for this retrospective analysis. Data including computed tomography (CT), surgical records, and cardiopulmonary bypass records were analyzed. Perioperatively survived patients were followed up, and long-term mortality and aortic re-interventions were recorded.ResultA total of 81 patients with arch anomalies were included, 35 with “bovine” anomalies, 23 with an aberrant right subclavian artery, 22 with an isolated left vertebral artery, and one with a right-sided arch + aberrant left subclavian artery. The strategies of arch management and cannulation differed according to the anatomic variation of the aortic arch. In total, seven patients (9%) died after surgery. Patients with “bovine” anomalies had a higher perioperative mortality rate (14%) and incidence of neurological complications (16%). Overall, four patients died during the follow-up period, with a 6-year survival rate of 94.6% (70/74). A total of four patients underwent aortic re-intervention during the follow-up period; before the re-intervention, three received the en bloc technique (13.6% 3/22) and one received hybrid therapy (11.1% 1/9).ConclusionWith complete preservation and reconstruction of the supra-arch vessels, patients with type A aortic dissection combining arch anomalies can achieve a favorable perioperative prognostic outcome. Patients who received the en bloc technique are more likely to require aortic re-intervention than patients who underwent total arch replacement with a four-branched graft vessel. Cannulation strategies should be tailored according to the variation of anatomy, but routine cannulation with the right axillary artery can still be performed in most patients with arch anomalies, even for patients with an aberrant right subclavian artery.
Ozone concentration at various heights near the surface layer in Shenyang, Northeast China
Authors: Li Liguang , Liu Ningwei , Shen Lidu , Zhao Ziqi , Wang Hongbo , Wang Yangfeng , Li Xiaolan , Ma Yanjun 
Published: September 2022

Ozone pollution has been growing in the recent decade, becoming a critical urban environmental issue in China. However, Shenyang’s near-surface ozone concentration (ground to 100 m altitude) is of grave concern. To obtain the ozone concentration and the corresponding meteorological conditions from 1 October 2018, to 30 September 2019, we built observatory sites at low (≈15 m) and high (≈90 m) layers in Shenyang, northeast China. Then, we analyzed the temporal variation of ozone concentration and discussed the relationship between ozone concentration and the meteorological factors at low and high layers. Compared with the high layer, the ozone concentration in the low layer is chartered with an earlier peak and higher diurnal range. The ozone concentration in all seasons first peaked at a low-layer height, in early in winter (15:00) and late summer (17:00). Then, the peak at high-layer height lagged for behind 1–2 h, generally occurring between 17:00 and 19:00. The variations in ozone concentration at low and high layers differed in daytime and nighttime. The diurnal ranges of ozone concentrations at the low layer were higher than those at the high layer in the four seasons examined. Overall, ozone concentration correlated significantly with air temperature, having correlation coefficients of 0.814 (p &lt; 0.05) in the low layer and 0.731 (p &lt; 0.05) in the high layer. Inversely, it showed a weak correlation with relative humidity: 0.310 (p &lt; 0.05) and 0.351 (p &lt; 0.05) in the low and high layers, respectively. Also, the correlation coefficients with wind speed were meager at both layers. Generally, ozone pollution is not severe in Shenyang.
In-situ synthesis of 3D BiOBr/UiO-66-NH2 heterojunction nanocomposite and its excellent photocatalytic degradation of rhodamine B dye
Authors: Feng Shuna , Yan Zheng , Ni Qianqian , Zhang Yun 
Published: September 2022

As a primary goal, The fast recombination of stimulated excitons and poor visible light response are key problems in the photocatalysis field. Combining with materials with good visible light responses to form heterogeneous structures is still the most effective way. In this study, BiOBr/UiO-66-NH2 photocatalyst was synthesized by a simple method. BiOBr is a 3D spherical structure stacked by nanosheets, which enhance its adsorption capacity for pollutants and catalyze the dark reaction to reach the equilibrium point for too long. Coupling with UiO-66-NH2, its adsorption capacity was inhibited and the dark reaction time was shortened. The excellent removal rate of Rhodamine B (RhB) by BiOBr/UiO-66-NH2 reached 96.79% after 30 min of visible light irradiation and 99.37% after 90 min. With an increase in pollutant concentration, the composite still showed excellent photocatalytic performance. This study also tried to abandon the dark adsorption stage and directly degraded RhB efficiently and quickly under visible light. Finally, the photocatalytic enhancement mechanism was proposed.
Construction of a focal adhesion signaling pathway-related ceRNA network in pelvic organ prolapse by transcriptome analysis
Authors: Yu Xia , He Li , Chen Ying , Lin Wenyi , Liu Hong , Yang Xiu , Ye Ying , Zheng Xuemei , Yang Zhenglin , Lin Yonghong 
Published: September 2022

Objective: Pelvic organ prolapse (POP) affects a large proportion of adult women, but the pathogenesis of POP remains unclear. The increase in global population aging will impose a substantial medical burden. Herein, we aimed to explore the related RNAs regulating the occurrence of POP and provide potential therapeutic targets.Method: Tissue biopsies were collected from the anterior vaginal wall of six women with POP and six matched subjects without POP. The profiles of mRNAs, circRNAs, lncRNAs, and miRNAs were obtained by whole transcriptome RNA sequencing.Result: The findings revealed that 71 circRNAs, 76 known lncRNAs, 84 miRNAs, and 931 mRNAs were significantly altered (p &lt; 0.05 and |log2FC| &gt; 1). GO and KEGG enrichment analyses indicated that the differentially expressed genes (DEGs) were mainly enriched in the focal adhesion signaling pathway. FLT, ITGA9, VEGFD, PPP1R12B, and ROCK2 were identified as focal adhesion signaling pathway-related hub genes by protein–protein interaction network analysis. Based on the relationships between the DEGs and miRNA, lncRNA and circRNA targets, we constructed a focal adhesion signaling pathway-related ceRNA network. The ceRNA network includes hsa_circ_0002190/hsa_circ_0046843/lnc-CARMN -miR-23a-3p - ROCK2 and hsa_circ_0001326/hsa_circ_0007733/lnc-AC107959/lnc-TPM1-AS - miR-205-5p - ROCK2/PPP1R12B/VEGFD. Moreover, abnormalities in the cytoskeleton in fibroblasts from individuals with POP were observed.Conclusion: In this study, a focal adhesion signaling pathway-related ceRNA network was constructed, and this network may serve as a target for finding suitable drugs for the treatment of POP.
Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation
Authors: Zhao Hairong , Lu Jiaming , He Furong , Wang Mei , Yan Yunbo , Chen Binyang , Xie De , Xu Chenxi , Wang Qiang , Liu Weidong , Yu Wei , Xi Yuemei , Yu Linqian , Yamamoto Tetsuya , Koyama Hidenori , Wang Wei , Zhang Chenggui , Cheng Jidong 
Published: September 2022

AimNumerous reports have demonstrated the key importance of macrophage-elicited metabolic inflammation in insulin resistance (IR). Our previous studies confirmed that hyperuricemia or high uric acid (HUA) treatment induced an IR state in several peripheral tissues to promote the development of type 2 diabetes mellitus (T2DM). However, the effect of HUA on glucose uptake and the insulin sensitivity of macrophages and its mechanism is unclear.MethodsTo assess systemic IR, we generated hyperuricemic mice by urate oxidase knockout (UOX-KO). Then, glucose/insulin tolerance, the tissue uptake of 18F-fluorodeoxyglucose, body composition, and energy balance were assessed. Glucose uptake of circulating infiltrated macrophages in the liver was evaluated by glucose transporter type 4 (GLUT-4) staining. Insulin sensitivity and the insulin signaling pathway of macrophages were demonstrated using the 2-NBDG kit, immunoblotting, and immunofluorescence assays. The immunoprecipitation assay and LC-MS analysis were used to determine insulin receptor substrate 2 (IRS2) levels and its interacting protein enrichment under HUA conditions.ResultsCompared to WT mice (10 weeks old), serum uric acid levels were higher in UOX-KO mice (WT, 182.3 ± 5.091 μM versus KO, 421.9 ± 45.47 μM). Hyperuricemic mice with metabolic disorders and systemic IR showed inflammatory macrophage recruitment and increased levels of circulating proinflammatory cytokines. HUA inhibited the nuclear translocation of GLUT-4 in hepatic macrophages, restrained insulin-induced glucose uptake and glucose tolerance, and blocked insulin IRS2/PI3K/AKT signaling. Meanwhile, HUA mediated the IRS2 protein degradation pathway and activated AMPK/mTOR in macrophages. LC-MS analysis showed that ubiquitination degradation could be involved in IRS2 and its interacting proteins to contribute to IR under HUA conditions.ConclusionThe data suggest that HUA-induced glucose intolerance in hepatic macrophages contributed to insulin resistance and impaired the insulin signaling pathway via IRS2-proteasome degradation
A radiogenomics biomarker based on immunological heterogeneity for non-invasive prognosis of renal clear cell carcinoma
Authors: Gao Jiahao , Ye Fangdie , Han Fang , Jiang Haowen , Zhang Jiawen 
Published: September 2022

BackgroundTumor immunological heterogeneity potentially influences the prognostic disparities among patients with clear cell renal cell carcinoma (ccRCC); however, there is a lack of macroscopic imaging tools that can be used to predict immune-related gene expression in ccRCC.MethodsA novel non-invasive radiogenomics biomarker was constructed for immune-related gene expression in ccRCC. First, 520 ccRCC transcriptomic datasets from The Cancer Genome Atlas (TCGA) were analyzed using a non-negative matrix decomposition (NMF) clustering to identify immune-related molecular subtypes. Immune-related prognostic genes were analyzed through Cox regression and Gene Set Enrichment Analysis (GSEA). We then built a risk model based on an immune-related gene subset to predict prognosis in patients with ccRCC. CT images corresponding to the ccRCC patients in The Cancer Imaging Archive (TCIA) database were used to extract radiomic features. To stratify immune-related gene expression levels, extracted radiogenomics features were identified according to standard consecutive steps. A nomogram was built to combine radiogenomics and clinicopathological information through multivariate logistic regression to further enhance the radiogenomics model. Mann–Whitney U test and ROC curves were used to assess the effectiveness of the radiogenomics marker.ResultsNMF methods successfully clustered patients into diverse subtypes according to gene expression levels in the tumor microenvironment (TME). The relative abundance of 10 immune cell populations in each tissue was also analyzed. The immune-related genomic signature (consisting of eight genes) of the tumor was shown to be significantly associated with survival in patients with ccRCC in TCGA database. The immune-related genomic signature was delineated by grouping the signature expression as either low- or high-risk. Using TCIA database, we constructed a radiogenomics biomarker consisting of 11 radiomic features that were optimal predictors of immune-related gene signature expression levels, which demonstrated AUC (area under the ROC curve) values of 0.76 and 0.72 in the training and validation groups, respectively. The nomogram built by combining radiomics and clinical pathological information could further improve the predictive efficacy of the radiogenomics model (AUC = 0.81, 074).ConclusionsThe novel prognostic radiogenomics biomarker achieved excellent correlation with the immune-related gene expression status of patients with ccRCC and could successfully stratify the survival status of patients in TCGA database. It is anticipated that this work will assist in selecting precise clinical treatment strategies. This study may also lead to precise theranostics for patients with ccRCC in the future.
Composition and regulation of the immune microenvironment of salivary gland in Sjögren’s syndrome
Authors: Tan Zhen , Wang Li , Li Xiaomei 
Published: September 2022

Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by exocrine gland dysfunction and inflammation. Patients often have dry mouth and dry eye symptoms, which seriously affect their lives. Improving dry mouth and eye symptoms has become a common demand from patients. For this reason, researchers have conducted many studies on external secretory glands. In this paper, we summarize recent studies on the salivary glands of pSS patients from the perspective of the immune microenvironment. These studies showed that hypoxia, senescence, and chronic inflammation are the essential characteristics of the salivary gland immune microenvironment. In the SG of pSS, genes related to lymphocyte chemotaxis, antigen presentation, and lymphocyte activation are upregulated. Interferon (IFN)-related genes, DNA methylation, sRNA downregulation, and mitochondrial-related differentially expressed genes are also involved in forming the immune microenvironment of pSS, while multiple signaling pathways are involved in regulation. We further elucidated the regulation of the salivary gland immune microenvironment in pSS and relevant, targeted treatments.
Iron deposition heterogeneity in extrapyramidal system assessed by quantitative susceptibility mapping in Parkinson’s disease patients with type 2 diabetes mellitus
Authors: Li Wanyao , Gao Bingbing , Du Wei , Jiang Yuhan , Yang Jing , Hu Rui , Liu Yangyingqiu , Liu Na , Zhang Yukun , Song Qingwei , Miao Yanwei 
Published: September 2022

PurposeExcessive brain iron depositions were found in both patients with Parkinson’s disease (PD) and those with type 2 diabetes mellitus (T2DM). The present study aimed to explore iron deposition and heterogeneity in the extrapyramidal system in PD patients with T2DM using quantitative susceptibility mapping (QSM) and further to reveal the effect of T2DM on the changes in brain iron in patients with PD.Materials and methodsA total of 38 PD patients with T2DM (PDDM), 30 PD patients without T2DM (PDND), and 20 asymptomatic control subjects (CSs) were recruited for this study. All subjects underwent multiple MRI sequences involving enhanced gradient echo T2 star weighted angiography (ESWAN). The magnetic sensitivity values (MSV) and volume of the whole nuclei (MSVW, VW) and high iron region (MSVRII, VRII) were measured on the bilateral caudate nucleus (CN), the putamen (PUT), the globus pallidus (GP), the substantia nigra (SN), the red nucleus (RN) and the dentate nucleus (DN). Clinical and laboratory data were recorded, especially for the Hoehn and Yahr (H-Y) stage, the Montreal Cognitive Assessment (MoCA), the Mini-Mental State Examination (MMSE), the Hamilton Depression Rating Scale (HAMD), and the Hamilton Anxiety Rating Scale (HAMA). All QSM data were compared between PDDM and PDND groups and correlated with clinical and laboratory data.ResultsCompared to the PDND group, the VRII/VW of the left CN was significantly increased in the PDDM group. Significantly higher MSVW and MSVRII were also found in the PDDM group, including bilateral SN of MSVW, right PUT, and bilateral CN, GP, and SN of MSVRII. The H-Y stage of the PDDM group was significantly higher than that of the PDND group. The MSVRII of bilateral RN of the PDDM group was positively correlated with the HAMA scores. HDL, DBP, and SBP levels were associated with MSVRII of right CN in the PDDM group.ConclusionT2DM could aggravate the disease severity and anxiety in patients with PD. The iron distribution of deep gray matter nuclei in PD patients with T2DM was significantly heterogeneous, which was related to blood pressure and blood lipids.
Risk Factors of Residual Dizziness After Successful Treatment for Benign Paroxysmal Positional Vertigo in Middle-Aged and Older Adults
Authors: Fu Wei , He Feng , Bai Ya , An Xinyue , Shi Ying , Han Junliang , Wang Xiaoming 
Published: September 2022

ObjectiveThe purpose of this study was to analyze risk factors of residual dizziness (RD) after successful treatment for benign paroxysmal positional vertigo (BPPV) in middle-aged and older adults.Methods181 patients with BPPV, after successful canalith repositioning maneuver (CRM) treatment, were recruited. All patients were divided into the middle-aged group (aged 45–59 years, n = 101) and the older group (over 60 years, n = 80). The clinical characteristics were recorded, including age, gender, numbers of maneuvers, involved canal, affected side, RD, comorbidities, dizziness handicap inventory score, and generalized anxiety disorder's 7-item scale score.ResultsThe incidence of RD in the older group was significantly higher than that of the middle-aged group (p = 0.033). Multivariate logistic regression analysis shows that age (odds ratio = 1.042, p = 0.006), moderate to severe dizziness (odds ratio = 2.017, p = 0.034), and moderate to severe anxiety (odds ratio = 2.228, p = 0.017) were independently associated with RD in middle-aged and older adults.ConclusionOlder adults exhibited higher incidence of RD after successful treatment for BPPV. Age, moderate to severe dizziness, and moderate to severe anxiety were independent risk factors of RD in middle-aged and older adults.
Lowering serum homocysteine in H-type hypertensive patients with atrial fibrillation after radiofrequency catheter ablation to prevent atrial fibrillation recurrence
Authors: Dong Youzheng , Huang Ting , Zhai Zhenyu , Dong Quanbin , Xia Zhen , Xia Zirong , Yu Jianhua , Jiang Xinghua , Hong Kui , Wu Yanqing , Cheng Xiaoshu , Li Juxiang 
Published: September 2022

BackgroundPrior investigation revealed that elevated serum total homocysteine (tHcy) are strongly correlated with atrial fibrillation (AF) recurrence. Herein, the goal of this study was to elucidate whether folic acid (FA) treatment reduced AF recurrence following radiofrequency catheter ablation (RFCA).MethodsTo conduct this retrospective research, we included consecutive H-type hypertensive AF patients, who were treated with first RFCA, between January 2010 and January 2022. We assessed the AF recurrence risk between patients who were taking 10 mg enalapril and 0.8 mg FA in a single-pill combination (enalapril–FA) daily and those who were taking a pill of 10 mg enalapril only. Outcomes were compared using the propensity-score matched analysis. Cox regression model was employed for the evaluation of AF recurrence events.ResultsOut of 2,714 patients, 645 patients receiving enalapril and 282 patients receiving enalapril-FA were included for analysis. Following propensity score matching, 239 patients remained in each group. These patients were followed-up for a median of 379 (137–596) days, and revealed that the enalapril-FA patients had drastically reduced AF recurrence, compared to the enalapril patients [adjusted hazard ratio (HR), 0.68; 95% confidence interval (CI), 0.48–0.97; P = 0.029]. Apart from this, no interactions were detected in the subgroup analysis.ConclusionIn H-type hypertensive AF patients who were treated with first RFCA, FA supplementation was correlated with a reduced AF recurrence risk.
Timing and intensity of physical activity and late sleeping habits among children in Japan
Authors: Matsuyama Yusuke , Isumi Aya , Doi Satomi , Shibata Ai , Ishii Kaori , Oka Koichiro , Fujiwara Takeo 
Published: September 2022

BackgroundLittle is known about what timing and intensity of physical activity (PA) are beneficial to preventing children’s late sleeping habits. We investigated the association between timing and intensity of PA and late sleeping habits among Japanese children.MethodsThe amount of PA on a weekday (light (&gt;1.5 to &lt;3.0 metabolic equivalents [METs]); moderate (3.0 to &lt;6.0 METs); and vigorous (6.0 to &lt;20.0 METs) was measured for the whole day, before school, during school, and after school, using accelerometers for population-based fourth-grade elementary school and eighth graders for 7 consecutive days between September and December 2018. Late sleeping habit (going to bed after 10 p.m. for fourth graders and after 11 p.m. for eighth graders) was assessed by questionnaires. The data of 229 fourth graders and 182 eighth graders were analyzed with Poisson regression adjusted for grade, gender, household income, body mass index (BMI), belonging to a sports club, wake-up time on weekdays, and PAs with different intensities.ResultsTotal PA was not associated with late sleeping habits. Light-intensity PA before school was protectively associated with late sleeping habits (prevalence ratio [PR]: 0.82, 95% confidence interval [CI]: 0.68, 0.99) while PA at school or after school was not.ConclusionLight-intensity PA before school may enhance the earlier bedtime of children.