bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corticotropin-Releasing Factor Aggravates Ischemic Stroke Injury by the Inflammatory Activation of Microglia
Authors: Wu Qiang , Feng Yan , Liu Ling , Liu Yang , Liu Xin , Zhang Liqiao , Li Yanan , Wang Liqun 
Published: February 2022

AbstractIschemic stroke is the second leading cause of death worldwide. Therefore, exploring effective and emerging molecular targets for ischemic stroke is a primary task of basic and clinical research. The aim of the present study was to investigate the function of corticotropin-releasing factor (CRF) in ischemic stroke and its related mechanisms, to provide a reference for the treatment of ischemic stroke. CRF, antalarmin, or astressin-2B were used to activate or block the CRF1 (CRF receptor 1) or CRF2 (CRF receptor 2) in BV2 cells and adult male mice, thus constructing a distal middle cerebral artery occlusion (dMCAO) model. CRF not only accelerated microglial activity by promoting transcription and production of inflammatory factors, but also promoted the transformation of activated BV2 cells from a neuroprotective phenotype (M2) to cytotoxic phenotype (M1), and these effects were mediated by the TLR4/NF-κB signaling pathway. These effects can be blocked by antalarmin but not by astressin-2B. CRF significantly aggravated the neurological deficit, increased infarction volume, and exacerbated neuronal injuries. Additionally, CRF significantly improved the levels of TNF-α and phospho-NF-κB in the ischemia penumbra. Finally, CRF significantly increased the number of CD16/Iba-1-positive cells and decreased the number of CD206/Iba-1-positive cells in the ischemia penumbra. These results provide evidence of the proinflammatory role of CRF in an ischemic stroke model and a possible underlying mechanism, which may facilitate the elucidation of potential treatment approaches for ischemic stroke.
Novel KDM6A Kabuki Syndrome Mutation With Hyperinsulinemic Hypoglycemia and Pulmonary Hypertension Requiring ECMO
Authors: Salguero Maria V , Chan Karen , Greeley Siri Atma W , Dyamenahalli Umesh , Waggoner Darrel , del Gaudio Daniela , Rajiyah Tara , Lemelman Michelle 
Published: February 2022

Abstract
Kabuki syndrome (KS) is a multisystem disorder estimated to occur in 1:32 000 newborns. Pathogenic mutations cause the majority but not all cases of KS in either KMT2D or KDM6A. KS can be suspected by phenotypic features, including infantile hypotonia, developmental delay, dysmorphic features, congenital heart defects, and others. Still, many of these features are not readily apparent in a newborn. Although neonatal hypoglycemia has been reported in 8% to 10% of patients with KS, the incidence and severity of hyperinsulinemic hypoglycemia (HH) is not well-studied. We present a full-term female infant with HH who was responsive to low-dose diazoxide. At 3 months of age, she was admitted for septic shock, worsening respiratory status, and severe pulmonary hypertension, requiring extracorporeal membrane oxygenation support. Her neonatal history was notable for hypotonia, dysphagia with aspiration requiring gastrostomy tube placement, and a cardiac defect—hypoplastic aortic arch requiring aortic arch repair. She has characteristic facial features, including prominent eyelashes, long palpebral fissures, and a short nasal columella. Next-generation sequencing for HH revealed a de novo likely pathogenic missense variant in KDM6A gene: c.3479G &gt; T, p.Gly1160Val that was absent from population databases. Genetic testing for causes of HH should include testing of the KS genes KMT2D and KDM6A. Early detection of the underlying genetic defect will help guide management as all reported HH cases associated with KS have been responsive to diazoxide. Affected infants with underlying cardiac conditions may be at higher risk of serious respiratory complications such as pulmonary hypertension.
Modeling anticipated changes in numbers of SARS-CoV-2 infections within communities due to immunization campaigns
Authors: Frey Kurt , Hagedorn Brittany , McCarthy Kevin A. , Hutubessy Raymond , Wang Susan Annemarie 
Published: February 2022

Background: As SARS-CoV-2 spread in early 2020, uncertainty about the scope, duration, and impact of the unfolding outbreaks caused numerous countries to interrupt many routine activities, including health services. Because immunization is an essential health service, modeling changes in SARS-CoV-2 infections among communities and health workers due to different vaccination activities was undertaken to understand the risks and to inform approaches to resume services. Methods: Agent-based modeling examined the impact of Supplemental Immunization Activities (SIAs) delivery strategies on SARS-CoV-2 transmission in communities and health workers for six countries capturing various demographic profiles and health system performance: Angola, Ecuador, Lao PDR, Nepal, Pakistan, and Ukraine. Results: Urban, fixed-post SIAs during periods of high SARS-CoV-2 prevalence increased infections within the community by around 28 [range:0-79] per 1000 vaccinations. House-to-house SIAs in mixed urban and rural contexts may import infections into previously naïve communities. Infections are elevated by around 60 [range:0-230] per 1000 vaccinations, but outcomes are sensitive to prevalence in health workers and SIA timing relative to peak. Conclusions: Younger populations experience lower transmission intensity and fewer excess infections per childhood vaccine delivered. Large rural populations have lower transmission intensity but face a greater risk of introduction of SARS-CoV-2 during an SIA.
Large-scale assessment of 7-11-year-olds’ cognitive and sensorimotor function within the Born in Bradford longitudinal birth cohort study
Authors: Hill Liam JB , Shire Katy A. , Allen Richard J , Crossley Kirsty , Wood Megan L , Mason Dan , Waterman Amanda H 
Published: February 2022

Background: Cognitive ability and sensorimotor function are crucial aspects of children’s development, and are associated with physical and mental health outcomes and educational attainment. This paper describes cross-sectional sensorimotor and cognitive function data collected on over 15,000 children aged 7-10 years, collected as part of the Born in Bradford (BiB) longitudinal birth-cohort study. Methodological details of the large-scale data collection process are described, along with initial analyses of the data involving the relationship between cognition/sensorimotor ability and age and task difficulty, and associations between tasks. Method: Data collection was completed in 86 schools between May 2016 and July 2019. Children were tested at school, individually, using a tablet computer with a digital stylus or finger touch for input. Assessments comprised a battery of three sensorimotor tasks (Tracking, Aiming, & Steering) and five cognitive tasks (three Working Memory tasks, Inhibition, and Processing Speed), which took approximately 40 minutes. Results: Performance improved with increasing age and decreasing task difficulty, for each task. Performance on all three sensorimotor tasks was correlated, as was performance on the three working memory tasks. In addition, performance on a composite working memory score correlated with performance on both inhibition and processing speed. Interestingly, within age-group variation was much larger than between age-group variation. Conclusions: The current project collected computerised measures of a range of cognitive and sensorimotor functions at 7-10 years of age in over 15,000 children. Performance varied as expected by age and task difficulty, and showed the predicted correlations between related tasks. Large within-age group variation highlights the need to consider the profile of individual children in studying cognitive and sensorimotor development. These data can be linked to the wider BiB dataset including measures of physical and mental health, biomarkers and genome-wide data, socio-demographic information, and routine data from local health and education services.
Understanding the implementation of telepractice in speech and language services for children and adults using a mixed-methods approach
Authors: Shankar Varsha , Ramkumar Vidya , Kumar Shuba 
Published: February 2022

Background: Telepractice emerged as a solution to overcome the challenges of access issues in the delivery of healthcare. Telepractice in speech language pathology (SLP) has existed for nearly a decade yet there is a significant knowledge gap with respect to the factors influencing the implementation of telepractice as a routine or long-term, sustained effort. This mixed-methods study aimed to identify implementation factors that influence the provision of telepractice in SLP services. Method: A mixed-methods study consisting of a scoping review and semi-structured interviews (SSI) was carried out. Articles that described telepractice in SLP were included based on an operational definition of implementation and a set of inclusion criteria. Results: Data was extracted from 11 studies that were mapped to nine projects in telepractice in SLP. The broad focus areas identified included diagnostics and evaluation, therapeutics and comprehensive assessment, management and follow-up care services. Synchronous/ real-time telepractice methods were always used for the provision of diagnostic testing or when providing therapy services using video conferencing. The ‘professional-facilitator-patient’ model was used most commonly followed by the ‘professional-patient’ model. Barriers for long-term sustainability included inadequate initial capital investment, lack of reimbursement and payment options, low internet speed and bandwidth, resistance and hesitancy to use telepractice from the patient’s end, lack of organizational policies and uniform regulations. Sustainable source of funding, having a dedicated team of professionals and technicians with clear roles and responsibilities, and inclusion of systematic planning facilitated implementation. Conclusion: In general, telepractice in SLP was not explicitly guided by implementation science or framework. The use of implementation frameworks ensures systematic planning and feasibility assessment to inform the scale-up of implementation. Therefore, it would be worthwhile for program implementers to consider these aspects when exploring telepractice services.
Nacionalidade versus Jihad: a competição entre o extremismo islâmico e a identidade nacional em Estados não-muçulmanos | Nationality versus Jihad: the competition between Islamic extremism and national identitity in non-muslim States
Authors: Costa Leandro Loureiro 
Published: February 2022

O objetivo desta pesquisa foi o de responder qual é a função do enfraquecimento da identidade nacional no crescimento da violência jihadista. Para isso, foram analisados os textos que versam sobre o jihadismo e o Estado Islâmico, e a literatura especializada no processo de crise do Estado-nação e na importância da nacionalidade na coesão social. As principais conclusões encontradas apontam que a erosão da soberania política e da identidade baseada na nação têm criado um cenário propício para a fragmentação social e a anomia em países ocidentais, o que possibilitou a emergência de propostas radicais estruturadas na identidade, como o jihadismo e a extrema-direita nacionalista. Dessa forma, foi concluído que o jihadismo disputa a lealdade de imigrantes muçulmanos, com a nacionalidade baseada no Estado. Palavras-chave: Jihadismo; Crise do Estado-nação; Violência.ABSTRACTThe objective of this research was to answer what is the role of weakening national identity in the growth of jihadist violence. For that, the texts that deal with jihadism and the Islamic State were analyzed, as well as the specialized literature on the crisis process of the nation-state and on the importance of nationality in social cohesion. The main conclusions found point out that the erosion of political sovereignty and nation-based identity has created a favorable scenario for social fragmentation and anomie in Western countries, which has made possible the emergence of radical proposals structured in identity, such as jihadism and the far-right nationalism. Thus, it was concluded that jihadism disputes the loyalty of muslim immigrants, with state-based nationality. Keyword: Jihadism; Nation-state crisis; Violence. Recebido em 24 abr. 2021 | Aceito em 10 ago. 2021.
Nacionalismo na Índia de Narendra Modi e do Bharatiya Janata Party (BJP) | Narendra Modi, the Bharatiya Janata Party (BJP) and Nationalism in India
Authors: Nicolini Gabriel João Paulo , Mandelbaum Henoch Gabriel , Carvalho Carlos Eduardo , Artioli Marcel 
Published: February 2022

O artigo analisa peculiaridades significativas do governo Modi dentre os nacionalismos "de direita". Elementos tradicionais indianos sustentam personalismo e chauvinismo religioso. Medidas de liberalização econômica se mesclam com estratégias estatais de desenvolvimento, como desde os anos 1990, com ênfase em setores de alta tecnologia. Leis agrícolas para modernizar a atividade rural encontram forte reação de milhões de agricultores que se sentem ameaçados. Reformas na tributação e no sistema monetário buscam fortalecer o Estado e concentrar poder no governo central. A política externa mantém orientações tradicionais para transformar a Índia em potência global. Modi cultiva a imagem de líder forte e capaz de estabelecer políticas assertivas em disputas com a China, mas preserva as relações com Pequim. Diversificação de parcerias e negociação de acordos comerciais procuram fortalecer a autonomia nacional e reforçam a concepção de soberania como valor que acompanha historicamente o desejo de modernização produtiva. Palavras-chave: nacionalismo hindu; Narendra Modi, BJP.ABSTRACTThe article analyzes the expressive peculiarities of Modi's administration among "right-wing" nationalisms. Traditional Indian elements underpin personalism and religious chauvinism. Since the 1990s, economic liberalization measures have been intertwined with state development strategies, emphasizing high-tech sectors. Agricultural legislation to modernize rural activity has faced strong reactions from millions of farmers. Tax and monetary system reforms seek to strengthen the state and concentrate power in the central government. The foreign policy maintains traditional guidelines to morph India into a global power. Modi cultivates the image of a strong leader capable of establishing strategies in disputes with China while preserving relations with Beijing. Diversification of partnerships and negotiation of trade agreements aim to highlight national autonomy and the concept of sovereignty as a value that historically accompanies the desire for productive modernization. Key-words: Hindu nationalism; Narendra Modi; BJP. Recebido em: 30 mai. 2021 | Aceito em: 02 dez. 2021.
A Política Externa Paraguaia e Boliviana Frente às lideranças do Brasil e da Venezuela na América do Sul | Paraguayan and Bolivian Foreign Policy in front of the leadership of Brazil and Venezuela in South America
Authors: Saraiva Miriam Gomes , Gonçalves Ana Lúcia De Lacerda , Clemente Stephanie Braun 
Published: February 2022

Utilizando o método da Política Externa Comparada, o artigo aborda como a Bolívia e o Paraguai reagiram, através de suas políticas externas, às lideranças do Brasil e da Venezuela na América do Sul, no início dos anos 2000. Através da comparação identifica se tais comportamentos significavam maior ou menor grau de dependência frente a alguma dessas lideranças. Sua principal contribuição é trazer luz para o método comparado em uma análise de política externa que versa sobre Estados com contextos políticos internos discrepantes e como estes conduziram suas políticas externas frente aos países líderes regionais em situações chave de suas histórias; a saber, o caso da nacionalização dos hidrocarbonetos, na Bolívia, e os casos da renegociação do Tratado de Itaipu e a problemática dos brasiguaios, no Paraguai.Palavras-chave: Política Externa Comparada. Bolívia. Paraguai.Abstract: The article address how Bolivia and Paraguay reacted, in their foreign policies, to the leadership of Brazil and Venezuela in South America in the early 2000s, using the method of Comparative Foreign Policy. Thus, it identifies whether such behaviour meant a greater or lesser degree of dependence on any of these leaderships. Its main contribution is to bring light to the comparative method in an analysis of foreign policy that deals with States with differing internal political context and how they conducted their foreign policies towards the leading regional countries in key situations in their history; namely, the case of the nationalization of hydrocarbons in Bolivia, the cases of renegotiation of the Treaty of Itaipu and the problem of brasiguaios in Paraguay.Keywords: Comparative Foreign Policy. Bolivia. Paraguay. Recebido em: 04 jun. 2021 | Aceito em: 17 nov. 2021.
Os Dragões internos na China: uma contribuição a partir dos estudos do Nacionalismo | Internal Dragons in China: A Contribution from Nationalism Studies
Authors: Pimenta Bueno Mariana , Junqueira Philipe Alexandre , Alves Santana Gustavo 
Published: February 2022

A presente pesquisa procura demonstrar de maneira breve os desafios políticos no aspecto do nacionalismo no país que vem, nos últimos anos, atraindo olhares: a China. Ao longo de três seções, nós analisamos a temática dos estudos nacionalistas, em como o Partido Comunista Chinês administra os enclaves da multietnicidade existente no território e as implicações de determinadas políticas promovidas pelo governo de Xi Jinping para controle de minorias através da tecnologia na presente Era Digital. O “Sonho Chinês” é assim exposto para ilustrar e problematizar a ilação entre políticas nacionalistas e identitárias com o controle do Partido em meio a um cenário mais desafiador para a China.Palavras-Chave: China; Nacionalismo; MultietnicidadeABSTRACT This research seeks to briefly demonstrate the political challenges considering the nationalism aspect in the country which is, in recent years, getting attention: China. Throughout three sections, we address the nationalist studies issue, how the Chinese Communist Party manages the enclaves from an existing multiethnicity on the territory and the implication of specifics policies provided by Xi Jinping’s Government. Thus the “Chinese Dream” is outline to illustrate and discuss an inference between nationalist and identities policies with the Party control through a more challenging arena for China. Keywords: China; Nationalism; Multiethinicity. Recebido em: 15 jun. 2021 | Aceito em: 20 set. 2021.
Mindfulness-based interventions to reduce stress and burnout in nurses: an integrative review
Authors: Armstrong Jacob W , Tume Lyvonne N 
Published: February 2022

Background/Aims With work-related stress and the current COVID-19 pandemic, nurses are at heightened risk of stress and burnout. Mindfulness-based interventions have been seen to decrease stress and burnout, yet research into the effectiveness for nursing staff is limited. This review adds to the growing body of literature surrounding mindfulness and explores the benefit it may have for clinical professionals. The aim of this study was to review and critically appraise the evidence around the effectiveness of mindfulness-based interventions to help reduce stress and/or burnout in nurses working in acute hospital settings. Methods The CINAHL, Medline and PsychInfo databases were searched using the key words Mindfulness, ‘Mindfulness-based’, MBSR, Nurs*, Stress and Burnout. Results A total of 11 research papers were identified, all of which found a reduction in stress and burnout for nurses working in acute hospital settings after the use of a mindfulness-based intervention. Mindfulness-based interventions can be adapted to suit nursing schedules while maintaining efficacy, but uncertainties remain around the optimisation of the length and delivery of these for integration into the NHS. Conclusions Mindfulness-based interventions may be an effective intervention to reduce stress and burnout in nurses working in acute settings. However, further research to establish and test a standardised mindfulness-based intervention is required before it could be implemented into NHS settings.
IMPLEMENTAÇÃO DE AMBIENTE DE EMULAÇÃO EM NÉVOA COM SUPORTE A BLOCKCHAIN
Authors: Marques dos Santos Eduardo 
Published: February 2022

Um modelo centralizado baseado em nuvem tornou-se a abordagem padrão para aInternet das Coisas (Internet of Things, IoT) (GUBBI et al., 2013). Devido às limitações dessa arquitetura, propostas recentes estão propondo mudanças em direção a modelos e arquiteturas descentralizadas. A Computação em Névoa (fog computing) (BONOMI et al., 2012) tem trazido os recursos de computação em nuvem para perto das fontes de dados com o intuito de superar problemas relacionados a arquitetura IoT.
A CONSTITUIÇÃO DO SUJEITO NEGRO NA FILOSOFIA DE ACHILLE MBEMBE
Authors: Lima de Almeida Rogério 
Published: February 2022

A investigação almejou formular, a partir de uma análise conceitual, uma respostafilosófica ao seguinte questionamento: quais as delimitações conceituais para aconstituição do sujeito Negro na filosofia de Achille Mbembe, mais especificamente na obra Crítica da Razão Negra?
Uma (re)leitura das políticas de sentido do ensino de professores formadores, como atos de currículo por meio da imagem
Authors: Da Cruz Lima Daniel 
Published: February 2022

Esta pesquisa teve como objetivo a construção de uma exposição fotográfica onlineque foi capaz de mostrar os processos do cotidiano das ações do Grupo de PesquisaFormarSer/UEFS. Este grupo desenvolve uma pesquisa intitulada: “Tal formação, talensino? Uma (re) leitura das políticas de sentido do ensino de professores formadores, como atos de currículo que podem qualificar a formação do licenciado e suas práticas docentes em sala de aula”.
Aprofundamento do estudo e desenvolvimento do módulo de vigilância de interações medicamentosas do Sistema de Informações Estratégicas Municipais SisVIM-SIEM
Authors: De Oliveira Exiele Daniel Fagundes 
Published: February 2022

O Ministério da Saúde possui um setor dedicado à área de Informação e comunicação (DATASUS), que é o responsável pelo desenvolvimento e manutenção dos Sistemas de Informação em Saúde (SIS), utilizado pelos municípios brasileiros e pelas instituições de saúde (públicas e conveniadas).
Transmission performance of a 1.96  µm active mode-locked laser in smoke channel
Authors: Li Yingkui , Li Mengmeng , Duan Ruodong , Liu ZheQi , Wang Tianshu , Ma Wanzhuo , Tao Zonghui , Lou Yan , Jiang Huilin 
Published: February 2022

We demonstrate the data transmission characteristics of a 1.96 µm laser in an indoor simulated smoke channel. An active mode-locked thulium-doped fiber laser at 1961.63 nm can be generated, and the repetition rate is 2.11 GHz corresponding pulse duration of 12.47 ps. Therefore, the pulse can be modulated by a 2.11 Gb/s digital sequence to act as a carrier light source. The transmission characteristics of signal light under different visibility conditions of 0.5, 0.05, and 0.005 km are studied. Compared with the back-to-back conditions, the signal-to-noise ratios of the carrier can decrease after passing through the smoke channels, which are 3.93, 7.1, and 9.08 dB, respectively. At the same time, the received power jitter can increase from

±
0.16

to

±
1.14

d
B

. The sensitivity can be

−

19.52

d
B
m

at the visibility of 0.005 km. The experimental results show that thulium-doped mode-locked laser has an excellent performance in a smoke channel.