bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Alternatives to Landraces of Kale (Brassica oleracea Group Acephala) for Off-season Cultivation and Seed-to-seed Production in Kashmir Valley
Authors: Malik Geetika , Shabir Alima , Shah Rafiq Ahmad , Farooq Saima , Jabeen Asma , Mir J. I. , Sharma O. C. 
Published: June 2022

Aim: To characterize kale (Brassica oleracea group Acephala) germplasm well adapted for July to December cropping season in Kashmir valley for suitability for year round cultivation with respect to leaf yield (t/ha).
Study Design: Random Complete Block Design with two replications.
Place and duration of study: The study was done in Vegetable Experimental Field of ICAR-Central Institute of Temperate Horticulture, Srinagar, Jammu and Kashmir, India from 2017-18 to 2018-19.
Methodology: The germplasm comprising breeding lines and landraces as checks was sown and then transplanted at different times of the year to evaluate for leaf yield potential at edible maturity stage. The final yield for each genotype was calculated by summing up all pickings. Critical differences among genotypes for total leaf yield were calculated from ANOVA using OPSTAT online tool for one factor analysis.
Results: Considering the average performance of two years in terms of leaf yield in tone per hectare, NW-Saag-1 (24.77, 25.08 and 25.01), CITH-KC-16 (28.79, 26.74 and 11.20) and CITH-KC-18 (24.25, 24.14 and 11.91) were found to yield significantly better than local checks Khanyari (7.77, 8.47 and 21.31) and GM Dari (10.36, 15.98 and 9.65) when transplanted in May, June and July, respectively. Months of April, May, June, July and August were most conducive for normal nursery production followed by May to September transplanting to get economical yields. January sowing of selected genotypes in polyhouse along with added protection from polysheet resulted in vigorous and healthy seedlings. Their transplanting in the second fortnight of March resulted only in short vegetative phase of the crop followed by bolting and seed production. However, this approach came out as an opportunity to produce seed in 7 months (January to July) compared to 1 year normally taken in farmer adopted seed production method.
Conclusion: NW-Saag-1, CITH-KC-16 and CITH-KC-18 lines yielded significantly higher than local landrace kales for offseason cultivation and seed-to-seed technique of seed production is an economic and short method of kale seed production in Kashmir valley.
Bioinspired Vascular Stents with Microfluidic Electrospun Multilayer Coatings for Preventing In‐Stent Restenosis
Authors: Cheng Yi , Zhang Xiaoxuan , Liu Rui , Li Yazhou , Zeng Jiaqi , Zhou Min , Zhao Yuanjin 
Published: June 2022

AbstractIn‐stent restenosis (ISR) is seriously affecting the long‐term prognosis of vascular interventional therapy and leading to enormous medical burdens. Great efforts have been devoted to developing functional vascular stents with desired features and properties for effective ISR prevention. Here, a multifunctional bionic vascular stent with designed coatings prepared using microfluidic electrospinning technology is presented. Such stents are composed of biocompatible, drug‐loaded methylacrylated gelatin‐polyethylene glycol diacrylate (GelMA‐PEGDA) and polycaprolactone composite nanofibers on 316L stainless steel stents by an easy‐to‐operate step‐by‐step spraying method. Benefitting from the addition of polydopamine during the fabrications, the drug‐loaded composite nanofibers can adhere well to both the stent and the vascular wall. Furthermore, as the inner fibrous layer of the stent contacting the lumen is equipped with heparin‐vascular endothelial growth factor (Hep‐VEGF), it plays an anticoagulation role and promotes the growth of endothelial cells; while the outer layer contacts the vascular wall and releases rapamycin slowly, which can restrain smooth muscle proliferation. By implanting this into the rabbit carotid artery, the multi‐functional bionic demonstrates that the vascular stent can achieve good anti‐thrombosis and in‐stent restenosis effects, which indicates its potential values in vascular intervention and other biomedical fields.
Multimodal Fluorescence Switching Materials: One Dye to Have Them All
Authors: Otaegui Jaume Ramon , Carrascull‐Marín Aleix , Ruiz‐Molina Daniel , Hernando Jordi , Roscini Claudio 
Published: June 2022

AbstractOff/on, on/off, and on1/on2 fluorescence switching systems find application in a variety of areas, for each of which a particular dye or dye‐switch tether must be specifically designed and synthesized. Herein it is demonstrated that such tight requirement can be avoided by using easily prepared mixtures of readily available emitters and phase change materials (PCMs). By proper selection of the PCM and, if needed, additives, thermo‐ and photothermoresponsive materials showing all classes of emission switching modes can be prepared from a single dye and without chemical modifications. This strategy can be generalized to distinct emitters and, thanks to the facile and versatile printability of dye–PCM mixtures, it can be used for the fabrication of fluorescent patterns showing complex (photo)thermal responses with direct applicability in sensing and anti‐counterfeiting.
Expanding the phenotype of PIK3C2A related syndrome: Report of two siblings with novel features and genotype
Authors: Galarreta Carolina I. , Kennedy Colleen , Blair David R. , Slavotinek Anne 
Published: June 2022

AbstractA pair of siblings was ascertained due to multiple congenital anomalies, including strikingly similar facial, skeletal, and ocular abnormalities. Exome sequencing of both the children and their mother revealed two novel PIK3C2A variants in the siblings, c.4381delC (p.Arg1461Glufs*31) and c.1555C > T (p.Arg519Ter). PIK3C2A belongs to the Class IIa family of Phosphatidylinositol‐3‐kinases, which create second messenger lipids that regulate a wide range of downstream signaling pathways involved in cell growth, survival and migration. Tiosano et al. (2019) identified the first monogenic disorder associated with biallelic PIK3C2A loss‐of‐function variants (oculoskeletodental syndrome). The novel syndrome was characterized by short stature, coarse facial features, ocular and skeletal abnormalities. This report describes two additional siblings affected by the PIK3C2A‐related syndrome, confirms core clinical features, establishes intrafamilial variability and expands the phenotype to include proteinuria.
Controllable Droplet Sliding on a Smart Shape‐Memory Slippery Surface
Authors: He Yaoxu , Wang Zhe , Jiao Xiaoyu , Song Yingbin , Meng Junhui , Cheng Zhongjun 
Published: June 2022

AbstractRecently, slippery surfaces with controllable droplet sliding have aroused much attention in both fundamental research and realistic applications. However, for almost all existing surfaces, constant stimuli such as heat, light, magnetic field, etc., are indispensable. Herein, by constructing pit structures on a shape memory polymer and further infusing oil with low surface tension, we report a shape memory slippery surface that can overcome the above imperfection. Based on the shape memory performance, the surface can memorize a diverse pit size as the surface is stretched or recovered. With the variation of pit structure, the sliding performances for both water and organic liquid droplets can be reversibly adjusted between the rolling and pinning states. This work, based on the shape memory effect, reports smart droplet sliding control through regulating the surface microstructure, which not only provides a strategy for droplet sliding control, but also offers some ideas for designing novel intelligent slippery surfaces.
Educators' positive practices with refugee pupils at two schools in England
Authors: Prentice Caitlin M. 
Published: June 2022

AbstractExtensive evidence indicates that education is an integral part of the settling in process for refugee and asylum‐seeking children. Furthermore, it has been suggested that positive teaching practice with refugee pupils should be asset‐based and holistic in nature. The present study examines educators' positive practices with refugee pupils and explores factors that shape these practices. Data were collected through participant observation and semi‐structured interviews with 17 class teachers, specialist teachers and teaching assistants at two schools in England. Numerous examples of positive practices were identified, from creating welcoming environments to promoting social–emotional well‐being to supporting English language learning. Factors that shaped these practices were identified using an ecological model of educator development. Such factors included educators' individual pedagogical knowledge about teaching refugee pupils and collective school‐level knowledge and practices. Some aspects of the national education system, such as rigid exam‐based curricula, were also cited as influential. Overall, this study offers examples of how individual educators and schools managed to enact positive practices with refugee pupils despite an unsupportive national context.
Regeneration of Capto Core 700 resin through high throughput and laboratory scale studies and impact on production of a SARS‐CoV‐2 vaccine candidate
Authors: Konstantinidis Spyridon , Reinhart Seth R. , Castagna Christine , Poplyk Murphy R. , Rustandi Richard R. , Flor Kristen L. , Acevedo‐Skrip Jillian , Thompson Rachel , Wang Christopher J. , Wang Sheng‐Ching , Winters Michael A. 
Published: June 2022

AbstractDuring the development of a SARS‐CoV‐2 vaccine candidate, at the height of the COVID‐19 pandemic, raw materials shortages, including chromatography resins, necessitated the determination of a cleaning in place (CIP) strategy for a multimodal core‐shell resin both rapidly and efficiently. Here, the deployment of high throughput (HT) techniques to screen CIP conditions for cleaning Capto Core 700 resin exposed to clarified cell culture harvest (CCCH) of a SARS‐CoV‐2 vaccine candidate produced in Vero adherent cell culture are described. The best performing conditions, comprised of 30% n‐propanol and ≥0.75 N NaOH, were deployed in cycling experiments, completed with miniature chromatography columns, to demonstrate their effectiveness. The success of the CIP strategy was ultimately verified at the laboratory scale. Here, its impact was assessed across the entire purification process which also included an ultrafiltration/diafiltration step. It is shown that the implementation of the CIP strategy enabled the re‐use of the Capto Core 700 resin for up to 10 cycles without any negative impact on the purified product. Hence, the strategic combination of HT and laboratory‐scale experiments can lead rapidly to robust CIP procedures, even for a challenging to clean resin, and thus help to overcome supply shortages.
Organizing an in‐person nation‐wide Biology olympiad during the Covid‐19 pandemic
Authors: Ghukasyan Gayane , Tserunyan Vardges 
Published: June 2022

AbstractThe Covid‐19 pandemic has inspired the implementation of a number of online educational activities designed to promote appropriate measures, such as social distancing, in order to avoid spread of the disease. In these circumstances, ensuring that extracurricular activities in science education adapt to the changing situation is of crucial importance. Recognizing the important role high school science olympiads play in science education, we organized an in‐person socially distanced 2‐day examination for the final round of the Armenian National Biology Olympiad by using Classmarker, a web‐based in‐browser tool for administering exams. We believe that our experience with organizing this event will prove useful to other educators faced with uncertainty regarding the return to pre‐pandemic modes of instruction.
Levers for a corporate transition to a plastics circular economy
Authors: Barford Anna , Ahmad Saffy Rose 
Published: June 2022

AbstractWith the global economy not yet 10% circular, businesses are key stakeholders in designing new forms of resource use, especially large multinationals. However, compared with the wealth of studies on ‘born sustainable’ start‐ups, there is minimal case study or interview based research into how incumbent companies are approaching this transition. Focusing on plastics, we ask: how does one incumbent multinational company approach the circular economy transition? This paper presents a case study of the incumbent multinational chemical company Dow, a leading plastics manufacturer. Varied external stressors and drivers for the circular economy act upon a company (which also has its own imperatives), resulting in tentative steps towards circular economy. To date, these steps have tweaked the existing system rather than radically altering the business model. For companies, like for the entire global economy, this transition has only just begun. This paper identifies key drivers, enablers and barriers of the circular economy, none of which are fixed or immutable. Knowing which levers for change are available and effective could help policy makers to shift gear to enable quicker progress towards circularity. Overall, broad based support and engagement is needed to progress the circular economy, hence all stakeholders have roles to play in demanding and enacting circular practices.
Genetic variants in XPD gene and glioma susceptibility in Chinese children: A multicenter case–control study
Authors: Chen Yong‐Ping , Liao Yuxiang , Yuan Li , Huang Xiao‐Kai , Ruan Ji‐Chen , Lin Hui‐Ran , Miao Lei , Zhuo Zhen‐Jian 
Published: June 2022

AbstractBackgroundGlioma is one of the central nervous system (CNS) tumors in children, accounting for 80% of malignant brain tumors. Nucleotide excision repair (NER) is a vital pathway during DNA damage repair progression. Xeroderma pigmentosum group D (XPD) or excision repair cross‐complementing group 2 (ERCC2) is a critical factor in the NER pathway, playing an indispensable role in the DNA repair process. Therefore, the genetic variants in XPD may be associated with carcinogenesis induced by defects in DNA repair.MethodsWe are the first to conduct a multi‐center case‐control study to investigate the correlation between XPD gene polymorphisms and pediatric glioma risk. We chose three single nucleotide polymorphisms and genotyped them using the TaqMan assay.ResultsAlthough there is no significant association of these genetic variations with glioma susceptibility, the stratified analysis revealed that in the subtype of astrocytic tumors, the rs13181 TG/GG genotype enhanced glioma risk than the TT genotype, and carriers with two to three genotypes also elevated the tumor risk than 0‐1 genotypes.ConclusionIn conclusion, our findings provided an insight into the impact of XPD genetic variants on glioma risk.
Leadership journeys: Impacts of faculty professional development
Authors: Macdonald R. Heather , DeMolle Diondra , LeMay Lynsey E. , MacDonald Alyssa M. , Othus‐Gault Shannon M. , Tvelia Sean 
Published: June 2022

AbstractThis chapter presents the leadership journeys of five faculty who participated in the SAGE 2YC: Faculty as Change Agents project. These faculty stories illustrate the influence of the project on their leadership and work as mid‐level administrative or grassroots leaders. Key to the project was the explicit inclusion of leadership development in the professional development (PD). Learning about organizational frames and leadership approaches, the experience of faculty participants designing and leading their own workshops, and the resulting community of practice contributed to the leadership development of faculty participants. Implications and recommendations for leadership development of faculty members, critically important for colleges, concludes the chapter.
Countrywide cardiovascular disease prevention and control in 49 countries with different socio‐economic status
Authors: Khaltaev Nikolai , Axelrod Svetlana 
Published: June 2022

AbstractBackgroundCardiovascular disease (CVD) is the major noncommunicable disease (NCD) accounting for 17.9 million deaths. If current trends continue, the annual number of deaths from CVD will rise to 22.2 million by 2030. The United Nations General Assembly adopted a sustainable development goal (SDG) by 2030 to reduce NCD mortality by one‐third. The purpose of this study was to analyze the CVD mortality trends in different countries implementing World Health Organization (WHO) NCD Action Plan and emphasize effective ways to achieve SDG.MethodsWHO statistics, based on the Member‐States unified mortality and causes‐of‐death reports were used for analyzing trends and different interventions.ResultsReduction of CVD mortality from 2000 to 2016 in 49 countries was achieved for stroke at 43% and ischemic heart disease at 30%. Smoking prevalence and raised blood pressure (RBP) decreased in 84% and 55% of the countries. Eighty‐nine percent of high‐income countries (HIC) demonstrated a decline in tobacco smoking against 67% in middle‐income countries (MIC). Sixty‐nine percent of HIC demonstrated a decline in RBP against 15% in MIC. CVD management, tobacco, and unhealthy diet reduction measures are significantly better in HIC. The air pollution level was higher in MIC.ConclusionBuilding partnerships between countries could enhance their efforts for CVD prevention and successful achievement of SDG.
Optical Modulation of Antibiotic Resistance by Photoswitchable Cystobactamids
Authors: Testolin Giambattista , Richter Jana , Ritter Antje , Prochnow Hans , Köhnke Jesko , Brönstrup Mark 
Published: June 2022

AbstractThe rise of antibiotic resistance causes a serious health care problem, and its counterfeit demands novel, innovative concepts. The combination of photopharmacology, enabling a light‐controlled reversible modulation of drug activity, with antibiotic drug design has led to first photoswitchable antibiotic compounds derived from established scaffolds. In this study, we converted cystobactamids, gyrase‐inhibiting natural products with an oligoaryl scaffold and highly potent antibacterial activities, into photoswitchable agents by inserting azobenzene in the N‐terminal part and/or an acylhydrazone moiety near the C‐terminus, yielding twenty analogs that contain mono‐ as well as double‐switches. Antibiotic and gyrase inhibition properties could be modulated 3.4‐fold and 5‐fold by light, respectively. Notably, the sensitivity of photoswitchable cystobactamids towards two known resistance factors, the peptidase AlbD and the scavenger protein AlbA, was light‐dependent. While irradiation of an analog with an N‐terminal azobenzene with 365 nm light led to less degradation by AlbD, the AlbA‐mediated inactivation was induced. This provides a proof‐of‐principle that resistance towards photoswitchable antibiotics can be optically controlled.
Correlation analysis of the triglyceride glucose index and heart failure with preserved ejection fraction in essential hypertensive patients
Authors: Liao Li Ping , Yang Yang , Wu Yilin , Li Weizhen 
Published: June 2022

AbstractBackgroundTriglyceride glucose index (TyG index) is a novel marker of insulin resistance. Studies have shown that TyG index is closely associated with the occurrence of hypertension and cardiovascular disease. However, little is known about the correlation between TyG index and the occurrence of heart failure with preserved ejection fraction (HFpEF) in hypertensive patients.HypothesisOur study assumes that TyG index strongly correlates with occurence of HFpEF in hypertensive patients.MethodsThis research enrolled 559 hypertensive patients (273 patients with HFpEF and 286 without HFpEF) admitted to the Department of Cardiology of Jiading Branch of Shanghai General Hospital from 2020 to 2021 as the study subjects. Gender, age, diastolic blood pressure, systolic blood pressure (SBP), and heart rate (HR) were recorded at admission. Medication history and fasting blood samples were harvested after admission to detect laboratory index. Cardiac function and ventricular structure index were measured by echocardiography. Pearson correlation analysis was conducted to identify the correlation of TyG index with cardiac function and ventricular structure. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of TyG index in HFpEF with hypertension.ResultsHFpEF patients had higher diuretic use frequencies, fasting plasma glucose, NT‐proBNP, triglycerides, TyG index, left atrial diameter (LAD), left ventricular mass index (LVMI), the ratio of peak E‐velocity of mitral orifice to peak velocity of early diastolic mitral annulus (E/e′), and SBP but lower ratio of peak E of early diastolic maximum blood flow velocity to peak A of late diastolic maximum blood flow velocity of mitral orifice (E/A) and average e′ than non‐HFpEF patients. Moreover, TyG index was correlated with LAD, left ventricular ejection fraction (LVEF), LVMI, average e′, E/e′, and NT‐proBNP. The multivariate regression analysis suggested that TyG index, E/e′, and NT‐proBNP were independent risk factors for HFpEF in hypertensive patients. Compared with E/e′ and NT‐proBNP, the area under the ROC curve (0.778 [95% confidence interval: 0.707–0.849]) was the largest for TyG index.ConclusionTyG index is higher in HFpEF patients than in non‐HFpEF patients and related to cardiac diastolic function, which strongly correlates with occurrence of HFpEF in hypertensive patients.
A novel hybrid solar chimney power plant: Performance analysis and deployment feasibility
Authors: Abdelsalam Emad , Almomani Fares , Ibrahim Shadwa 
Published: June 2022

AbstractThis study presents a novel hybrid solar chimney power plant (HSCPP) design. The HSCPP preserves the typical solar chimney power plant (SCPP), with an additional seawater pool at the base and water sprinklers at the top. This new and novel design configuration offers an opportunity to run the system during the daytime as a traditional SCPP and as a downdraft cooling tower at night. The performance of the HSCPP was analyzed in 16 cities in the Kingdom of Saudi Arabia (KSA) that span the entire geographical area of the country to select the optimal location for installation. The results showed that the highest annual electrical energy production of 676.20 MWh was achieved in the southern city of Shahrurah. However, the lowest annual electrical energy production of 347.59 MWh was found at Wajh, in the west. The highest annual freshwater production was 143,898 tons at Riyadh, in the center. However, the lowest annual freshwater production was 77,868 tons at Muwayh, in the west. Furthermore, the results showed that the proposed HSCPP increased electrical power production by 55% and freshwater production by 20% when compared to traditional SCPP. In addition, an outstanding reduction in CO2 emissions by approximately 56% was associated with such an application of HSCPP. The performance of the HSCPP is very promising, however, the geographical location to install the HSCPP is performance‐critical. Hence, the optimal locations were found to be from the center to the southern part of the KSA.