bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hereditary Angioedema: The Clinical Picture of Excessive Contact Activation
Authors: Petersen Remy S. , Fijen Lauré M. , Levi Marcel , Cohn Danny M. 
Published: November 2022

AbstractHereditary angioedema is a rare, genetic disorder characterized by painful, debilitating and potentially life-threatening angioedema attacks in subcutaneous and submucosal tissue. While usually unpredictable, attacks can be provoked by a variety of triggers including physical injury and certain medication and are often preceded by prodromal symptoms. Hereditary angioedema has a profound influence on the patients' lives. The fundamental cause of hereditary angioedema in almost all patients is a mutation in the SERPING1 gene leading to a deficiency in C1-inhibitor. Subsequently, the contact activation cascade and kallikrein-kinin pathway are insufficiently inhibited, resulting in excessive bradykinin production triggering vascular leakage. While C1-inhibitor is an important regulator of the intrinsic coagulation pathway, fibrinolytic system and complement cascade, patients do not have an increased risk of coagulopathy, autoimmune conditions or immunodeficiency disorders. Hereditary angioedema is diagnosed based on C1-inhibitor level and function. Genetic analysis is only required in rare cases where hereditary angioedema with normal C1-inhibitor is found. In recent years, new, highly specific therapies have greatly improved disease control and angioedema-related quality of life. This article reviews the clinical picture of hereditary angioedema, the underlying pathophysiology, diagnostic process and currently available as well as investigational therapeutic options.
Gödel's Theorem: A Very Short Introduction
Authors: Moore A. W. 
Published: November 2022

Abstract
This book provides an introduction to Gödel’s theorem. Gödel’s theorem states that no axiomatization can determine the whole truth and nothing but the truth concerning arithmetic. The content of the theorem is elucidated and distinguished from that of other claims with which it is often confused. The significance of the theorem is also discussed. Particular emphasis is laid on the appeal of axiomatization and on attempts that were made, in the half century preceding Gödel’s proof, to provide the very thing that the theorem precludes. This includes discussion of Hilbert’s programme, part of which was to provide a consistent foundation for mathematics and to demonstrate its consistency by mathematical means. Two proofs of Gödel’s theorem are given. The second and more elaborate proof is also shown to yield Gödel’s second theorem: that no consistent axiomatization of arithmetic can be used to prove a statement corresponding to a statement of its own consistency. The final two chapters of the book explore the implications of Gödel’s results: for Hilbert’s programme; for the question whether the human mind, in its capacity to think beyond any given axiomatization of arithmetic, has powers beyond those of any possible computer; and for the nature of mathematics.
Anselm: A Very Short Introduction
Authors: Williams Thomas 
Published: November 2022

Abstract
Anselm of Canterbury (1033–1109) was the outstanding philosopher-theologian of the Latin West between Augustine and the thirteenth century. As a public figure, especially as Archbishop of Canterbury, he corresponded with kings and nobles, popes and bishops, in letters that reveal a fascinating personality and flesh out the practical dimensions of his theoretical philosophy. He wrote at a time when a renewed interest in logic encouraged careful and rigorous argumentation, but before the recovery of Aristotle filled the philosophical discourse with difficult technical jargon, making for writing that is unrivalled for its lucidity and accessibility. He offers the first clear account of what we nowadays call a libertarian view of free will, according to which free choices cannot be determined by the agent’s internal states or by external influences. His famous ‘ontological argument’ for the existence of God continues to generate discussion, debate, and puzzlement. His understanding of God is rightly regarded as one of the definitive expressions of classical theism or perfect-being theology, which remains influential in philosophy of religion and analytic theology. His account of the Atonement is one that every theologian to this day feels obligated to grapple with.
Investigation of the mechanical characteristics of the Cu/low-k BEOL under wire bonding process loading
Authors: Yuan Cadmus C A , Chang H M , Chiang K N 
Published: November 2022

ABSTRACT
Wire bonding is a key integrated circuit (IC) interconnect technology, and it adheres metal wires to the IC pad and substrate by applying significant compression and energic loading. On the other hand, the Cu/low-k technology of the advanced IC industry is driven by the market demands of small size, and low resistance-capacitance delay applications. Because material properties of Cu/low-k back end of line (BEOL) exhibit significant differences from the conventional Al-based system, 3 new reliability failure modes are introduced after the wire bonding process, including the Al pad lift, Cu pad lift and the nanoscaled Cu diffusion barrier crack. To study the mechanical characteristics of the Cu/low-k BEOL under the wire bonding process loading, this research establishes a set of transient numerical models with mesh control and computation acceleration techniques. The mechanical characteristics of the wire bonding process and the differences between the conventional and Cu/low-k BEOLs are analyzed via the detailed analysis of the historical stress plots over the wire bonding process time. Moreover, the risks of wire bonding induced the failure modes against different Cu/low-k designs are studied by the proper mechanical indices, and optimized design trends are suggested.
The Expressivity of Quantified Group Announcements
Authors: Alechina Natasha , van Ditmarsch Hans , French Tim , Galimullin Rustam 
Published: November 2022

Abstract
Group announcement logic (GAL) and coalition announcement logic (CAL) allow us to reason about whether it is possible for groups and coalitions of agents to achieve their desired epistemic goals through truthful public communication. The difference between groups and coalitions in such a context is that the latter make their announcements in the presence of possible adversarial counter-announcements. As epistemic goals may involve some agents remaining ignorant, counter-announcements may preclude coalitions from reaching their goals. We study the relative expressivity of GAL and CAL and provide some results involving their more well-known sibling APAL. We also discuss how the presence of memory alters the relationship between groups and coalition.
Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 Spike protein
Authors: Kuhn Christopher Cyrus , Basnet Nirakar , Bodakuntla Satish , Alvarez-Brecht Pelayo , Nichols Scott , Martinez-Sanchez Antonio , Agostini Lorenzo , Soh Young-Min , Takagi Junichi , Biertümpfel Christian , Mizuno Naoko 
Published: November 2022

AbstractSARS-CoV-2 is a novel coronavirus responsible for the COVID-19 pandemic. Its high pathogenicity is due to SARS-CoV-2 spike protein (S protein) contacting host-cell receptors. A critical hallmark of COVID-19 is the occurrence of coagulopathies. Here, we report the direct observation of the interactions between S protein and platelets. Live imaging showed that the S protein triggers platelets to deform dynamically, in some cases, leading to their irreversible activation. Strikingly, cellular cryo-electron tomography revealed dense decorations of S protein on the platelet surface, inducing filopodia formation. Hypothesizing that S protein binds to filopodia-inducing integrin receptors, we tested the binding to RGD motif-recognizing platelet integrins and found that S protein recognizes integrin αvβ3. Our results infer that the stochastic activation of platelets is due to weak interactions of S protein with integrin, which can attribute to the pathogenesis of COVID-19 and the occurrence of rare but severe coagulopathies.
The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate
Authors: Araya-Secchi Raul , Bugge Katrine , Seiffert Pernille , Petry Amalie , Haxholm Gitte W. , Lindorff-Larsen Kresten , Pedersen Stine F. , Arleth Lise , Kragelund Birthe B. 
Published: November 2022

AbstractClass 1 cytokine receptors transmit signals through the membrane by a single transmembrane helix to an intrinsically disordered cytoplasmic domain that lacks kinase activity. While specific binding to phosphoinositides has been reported for the prolactin receptor (PRLR), the role of lipids in PRLR signalling is unclear. Using an integrative approach combining NMR spectroscopy, cellular signalling experiments, computational modelling and simulation, we demonstrate co-structure formation of the disordered intracellular domain of the human PRLR, the membrane constituent phosphoinositide-4,5-bisphosphate (PI(4,5)P2) and the FERM-SH2 domain of the Janus kinase 2 (JAK2). We find that the complex leads to accumulation of PI(4,5)P2at the transmembrane helix interface and that mutation of residues identified to interact specifically with PI(4,5)P2negatively affects PRLR-mediated activation of signal transducer and activator of transcription 5 (STAT5). Facilitated by co-structure formation, the membrane-proximal disordered region arranges into an extended structure. We suggest that the co-structure formed between PRLR, JAK2 and PI(4,5)P2locks the juxtamembrane disordered domain of the PRLR in an extended structure, enabling signal relay from the extracellular to the intracellular domain upon ligand binding. We find that the co-structure exists in different states which we speculate could be relevant for turning signalling on and off. Similar co-structures may be relevant for other non-receptor tyrosine kinases and their receptors.
Work–life balance: is an entrepreneurial career the solution?
Authors: Tahir Rizwan 
Published: November 2022

Purpose
The present study, drawing on boundary theory, attempts to investigate entrepreneurs’ work–life balance (WLB) in terms of how they manage and construct the borders between their non-work and work lives.

Design/methodology/approach
The current qualitative study is grounded on in-depth interviews with 30 entrepreneurs currently living and working in the United Arab Emirates (UAE). When selecting the interviewees, the authors used purposeful sampling to ensure a diverse sample of interviewees with respect to nationality, age, gender and the nature of their business.

Findings
The findings suggest that most interviewees believe an entrepreneurial career can contribute positively to their lives. However, some individuals question whether it is possible to have some level of WLB while managing entrepreneurial businesses in the UAE’s competitive environment. Further, some entrepreneurs prioritize “work” over “family life,” indicating a love for their work and a lack of desire for any boundaries. Working long hours and managing a successful business over a longer period of time is also found to be negatively related to WLB.

Originality/value
Entrepreneurship has become a desirable career option, thus stimulating much research attention. However, little is known about entrepreneurs’ WLB challenges, especially regarding whether entrepreneurship improves individuals’ WLB. The present study uses boundary theory to understand how subjective insights regarding WLB and effective boundary management might address this gap.
Ustekinumab therapy for Netherton syndrome
Authors: Samuelov Liat , Shehadeh Waseem , Sarig Ofer , Gat Andrea , Matz Hagit , Sprecher Eli 
Published: November 2022

AbstractNetherton syndrome (NS) is a rare disorder of cornification associated with high morbidity. It is caused by bi‐allelic mutations in SPINK5 encoding the serine protease inhibitor LEKTI. Previous studies have shown Th17 skewing with IL‐23 upregulation in NS, raising the possibility that targeting these inflammatory pathways may alleviate disease manifestations. We ascertained the therapeutic efficacy of six doses of ustekinumab administered to three patients with NS over a period of 13 months using the Ichthyosis Area and Severity Index (IASI), the Dermatology Life Quality Index (DLQI), a visual analogue scale (VAS) for itch and the peak‐pruritus numeric rating scale (PP‐NRS). Histopathology analysis including CD3, CD4, CD8 and interleukin 17 (IL‐17) immunostaining, was performed at baseline and 4 weeks following the last ustekinumab dose. Total IASI scores were reduced by 28% in two patients at week 16 with sustained response by week 56. No consistent improvement in DLQI, VAS for itch and PP‐NRS scores was observed. The inflammatory infiltrate and the degree of acanthosis were slightly reduced at week 56 as compared to baseline. No significant change in immunostaining of the various inflammatory markers was observed at week 56. In conclusion, this case series did not demonstrate a significant therapeutic effect of ustekinumab in NS.
Serum levels of C‐C motif chemokine ligand 2 and interleukin‐8 as possible biomarkers in patients with toxic epidermal necrolysis accompanied by acute respiratory distress syndrome
Authors: Watanabe Tomoya , Watanabe Yuko , Ikeda Noriko , Aihara Michiko , Yamaguchi Yukie 
Published: November 2022

AbstractToxic epidermal necrolysis (TEN) is a fatal cutaneous adverse reaction that occasionally affects multiple organs. Acute respiratory distress syndrome (ARDS) is a rare complication that can cause rapid and potentially fatal pulmonary dysfunction. However, the mechanisms underlying TEN‐induced ARDS remain unknown. This retrospective single‐center study aimed to identify potential biomarkers for predicting ARDS onset in TEN patients. Pre‐treatment serum samples were collected from 16 TEN patients and 16 healthy controls (HCs). The serum levels of cytokines/chemokines were determined using the Luminex Assay Human Premixed Multi‐analyte kit. The expression levels of cytokines and chemokines in the skin were examined via immunohistochemistry. The serum levels of C‐C motif chemokine ligand 2 (CCL2), interleukin (IL)‐6, and IL‐8 were significantly higher in TEN patients with ARDS than in those without ARDS and in HCs, whereas those of CCL2 and IL‐8 were not significantly different between TEN patients without ARDS and HCs. There was no significant difference in CCL2 and IL‐8 expression in the skin between TEN patients with and without ARDS. Interestingly, there were no significant differences in the cytokine/chemokine levels between TEN and other organ damage, other than ARDS and TEN without any organ damage. We further analyzed the changes in cytokine/chemokine levels before and after treatment in two TEN patients with ARDS. CCL2, IL‐6, and IL‐8 levels decreased after systemic treatment compared to their baseline levels before treatment at an early stage. These results suggest that IL‐8 and CCL2 may be involved in the pathogenesis of TEN‐induced ARDS and have potential application as predictive markers for ARDS onset.
Herbivory damage but not plant disease under experimental warming is dependent on weather for three subalpine grass species
Authors: Lynn Joshua S. , Abo‐Sido Nisreen , McCowen Ian W. , Villanueva Shermila B. , Harte John , Rudgers Jennifer A. 
Published: November 2022

Abstract

Both theory and prior studies predict that climate warming should increase attack rates by herbivores and pathogens on plants. However, past work has often assumed that variation in abiotic conditions other than temperature (e.g. precipitation) do not alter warming responses of plant damage by natural enemies. Studies over short time periods span low variation in weather, and studies over long time‐scales often neglect to account for fine‐scale weather conditions.

Here, we used a 20+ year warming experiment to investigate if warming affects on herbivory and pathogen disease are dependent on variation in ambient weather observed over 3 years. We studied three common grass species in a subalpine meadow in the Colorado Rocky Mountains, USA. We visually estimated herbivory and disease every 2 weeks during the growing season and evaluated weather conditions during the previous 2‐ or 4‐week time interval (2‐week average air temperature, 2‐ and 4‐week cumulative precipitation) as predictors of the probability and amount of damage.

Herbivore attack was 13% more likely and damage amount was 29% greater in warmed plots than controls across the focal species but warming treatment had little affect on plant disease. Herbivory presence and damage increased the most with experimental warming when preceded by wetter, rather than drier, fine‐scale weather, but preceding ambient temperature did not strongly interact with elevated warming to influence herbivory.

Disease presence and amount increased, on average, with warmer weather and more precipitation regardless of warming.

Synthesis. The effect of warming over reference climate on herbivore damage is dependent on and amplified by fine‐scale weather variation, suggesting more boom‐and‐bust damage dynamics with increasing climate variability. However, the mean effect of regional climate change is likely reduced monsoon rainfall, for which we predict a reduction in insect herbivore damage. Plant disease was generally unresponsive to warming, which may be a consequence of our coarse disease estimates that did not track specific pathogen species or guilds. The results point towards temperature as an important but not sufficient determinant and regulator of species interactions, where precipitation and other constraints may determine the affect of warming.
How rational are voters when expecting government parties to fulfil pledges? A cross‐national survey experiment
Authors: HEINISCH REINHARD , WERNER ANNIKA 
Published: November 2022

AbstractThat parties fulfil their pre‐election pledges once they are in government is a fundamental idea of many democracy models. This paper addresses the question of whether the government/opposition status of their party affects how much citizens want governments to fulfil their promises. We hypothesize that interest‐driven, rational voters are more likely to prefer their own party to keep its promises and investigate whether this rationale is impacted by public opinion and expert views. The analysis is based on a survey experiment conducted in Australia and Austria. It finds that voters broadly adhere to the democratic principle of expecting pledge fulfilment but, at the same time, some take a rational approach to government promises. The opinions of the public and experts mitigate but do not change this effect. Another key finding is the significant difference in the preference for promise keeping versus promise breaking between government and opposition voters in the Austrian case, the country with the more heterogeneous and polarized political system. This paper contributes to the literature on voters’ attitudes on democracy and pledge fulfilment by showing that voters are normatively driven but a significant number of voters deviate and instead follow the rational voter logic.
Silicicolous lichen communities of the Ukrainian Crystalline Shield
Authors: Khodosovtsev Alexander , Darmostuk Valerii , Prylutskyi Oleh , Kuzemko Anna 
Published: November 2022

AbstractQuestionsHow many different silicicolous lichen syntaxa occur on the Ukrainian Crystalline Shield and what ecological factors are influencing their distribution?LocationUkrainian Crystalline Shield, Steppe and Forest–Steppe zones, Ukraine.MethodsThe field research was performed during 2013–2020. Analysis was done with the JUICE software using agglomerative hierarchical cluster analysis in the integrated PC‐Ord with data transformation, pseudospecies cut levels 0–5–25, distance measure – Jaccard, group linkage – Ward's method. For the ordination of the plots we used detrended correspondence analysis (DCA) and non‐metric multidimensional scaling (NMDS) with the “envfit” function, implemented in the R package vegan. As environmental variables we used mean indicator values obtained for each species from the ITALIC database. A generalized synoptic table, which combined both our own and literature data, was clustered using Euclidean distances and the Ward error sum of squares hierarchical clustering method with Ward's criterion.ResultsSeven clusters were obtained after JUICE analysis based on 197 relevés of lichen communities that included 119 lichen species. The main axis in both DCA and NMDS ordination is similar to the vector of substrate pH value. Communities on overhanging surfaces are acidophilous. Communities of water tracks are moderately basophilous to basophilous. Other communities included relevés on different granite characterized as mainly neutrophilous. Lichen communities on siliceous rocks of the Ukrainian Crystalline Shield are assigned to the classes Rhizocarpetea geographici, Leprarietea chlorinae, and Collematetea cristati. Two new alliances (Aspicilion intermutantis and Staurothelion frustulentae), four new associations and three subassociation are described.ConclusionSilicicolous lichen communities of the Ukrainian Crystalline Shield differ from the known units of Central Europe by species composition, where lichens with arid ecology are present. Their local distribution depends mainly on a combination of substrate pH, degree of eutrophication, protection from rain, and substrate moisture.
Moral courage and manager‐regret
Authors: Duckworth Craig 
Published: November 2022

AbstractIt has been suggested that moral courage in the workplace supports more robust application of regulatory principles. A workforce with the courage to act on moral imperative, it is argued, can bolster corporate governance and promote both more stable business organisations and greater economic stability at large. Research in the area investigates the bases of moral courage, a central implication being that businesses should invest in ethical training as a matter of public policy. It is standard to present moral courage as the strength of will to do the morally right thing. From a managerial perspective, however, this distorts the normative character of the kind of issues managers typically face. Doing the morally right thing commonly entails inflicting permissible harms. Such harms, though permissible, can be a source of moral concern to the conscientious manager. A difficulty for the standard account, then, is that moral courage may be expected in scenarios in which the moral implications of the manager's action have not been fully assessed. In this paper, an alternative account of moral evaluation is presented that incorporates the concern around permissible harms. The basis of such concern is found to be manager‐regret. Building on this foundation, we can establish a new definition of moral courage, that understands the right action to be that which entails defensible harms, and requires courage because those harms will likely have to be defended. It should be recognised in the academic literature that moral courage has this intellectual dimension. Furthermore, managerial training and practice should reflect this understanding of moral courage if its benefits to public policy, in particular corporate governance, are to be realised. The thesis takes a novel approach to the topic that draws, centrally, on the work of Bernard Williams, Martha Nussbaum and Søren Kierkegaard.