bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical shift assignments of calmodulin under standard conditions at neutral pH
Authors: Bej Aritra , Ames James B. 
Published: April 2022

AbstractThe Ca2+ sensor protein, calmodulin (CaM) is ubiquitously expressed in all cells where it binds to hundreds of different target proteins, including dozens of enzymes, receptors, ion channels and numerous Ca2+ transporters. The only published NMR chemical shift assignments for Ca2+-bound CaM (in the absence of a target) have been determined under acidic conditions: at pH 6.5/310 K (BMRB 6541) and pH 6.3/320 K (BMRB 547). However, some CaM/target complexes are not soluble under these conditions. Also, amide chemical shifts are very sensitive to pH and temperature, which can cause large baseline errors when using the existing chemical shift assignments of free CaM to calculate chemical shift perturbations caused by target binding at neutral pH and physiological temperature. We report complete NMR chemical shift assignments of Ca2+-saturated CaM under a set of standard conditions at neutral pH and 308 K that will enable more accurate chemical shift comparison between free CaM and CaM/target complexes (BMRB 51289).
Determinants of wellbeing in university students: The role of residential status, stress, loneliness, resilience, and sense of coherence
Authors: Brett Caroline E. , Mathieson Michelle L. , Rowley Avril M. 
Published: April 2022

AbstractMaintaining wellbeing in university students is a government priority, but robust evidence has been lacking. Higher wellbeing is associated with better mental and physical health, higher self-esteem, self-efficacy, and effective coping strategies. This study aimed to identify, through an online survey in 2018, key determinants of wellbeing amongst a sample of 574 (65.5% female) students across all levels of study at a university in the UK. Most respondents (526 (91.8%)) reported feeling unusually stressed or overwhelmed at university. Residential students reported higher loneliness and number of stressors than commuter students, and postgraduate students reported higher wellbeing, resilience, and sense of coherence, and lower perceived stress and loneliness. Hierarchical regression analyses showed that 71.8% of the variance in wellbeing was predicted by a model containing demographics (age/gender, level of study, number of stressors), psychosocial variables, and perceived stress, with perceived stress, sense of coherence, loneliness, and resilience the strongest predictors. The findings suggest that interventions designed to improve resilience and sense of coherence, and reduce loneliness and perceived stress are likely to be effective in enhancing wellbeing in a student population.
Multi-sided platforms in competitive B2B networks with varying governmental influence – a taxonomy of Port and Cargo Community System business models
Authors: Tessmann Ruben , Elbert Ralf 
Published: April 2022

AbstractOur knowledge on differences in business model characteristics of thriving and failing Multi-Sided Platforms in competitive B2B networks (B2B-MSP) and potential influences of increasing governmental involvement remains fragmented. This study develops a taxonomy to classify special B2B-MSP with varying governmental influence in the supply chain and transportation context, viz. Port and Cargo Community Systems (CS). Based on the classification of 44 international CS, we identify four archetypes using cluster analysis. The taxonomy provides practitioners with a differentiated view on the configuration options of CS business models including the involvement of governmental institutions, while the presented archetypes contribute an aggregated view of CS business models. The statistical analysis of our results provides initial explanatory approaches on CS business model dimension interdependencies, thereby laying the basis for a deeper understanding of sectoral and geographic differences of B2B-MSP and their diffusion dynamics as well as facilitating a higher contextualization of future research.
Altered Salivary Microbiota Following Bifidobacterium animalis Subsp. Lactis BL-11 Supplementation Are Associated with Anthropometric Growth and Social Behavior Severity in Individuals with Prader-Willi Syndrome
Authors: Liu Kevin , Kong Xue-Jun 
Published: April 2022

AbstractTo evaluate the influence of oral probiotic Bifidobacterium animalis subsp. lactis (BL-11) supplementation on salivary microbiota composition and the association with growth parameters, and behavioral symptoms in individuals with Prader-Willi syndrome (PWS). In this post hoc analysis, we included a subset of 36 PWS patients with available saliva samples from our original randomized, double-blinded, placebo-controlled trial (Chinese Clinical Trial Registry, ChiCTR1900022646, April 20, 2019). Among the 36 subjects, 17 subjects were allocated to the probiotic group for daily use of the BL-11 probiotic and 19 subjects were allocated to the placebo group. Groupwise and longitudinal differences in salivary microbiota abundances, biodiversity metrics, and height were analyzed. Linear correlations were found between identified differentially abundant salivary microbiota and clinical parameters. Salivary microbiome α-diversity was found to be higher in the probiotic-treated group at week 12 relative to placebo controls (P < 0.05). Leptotrichia, Paracoccus, and Faecalibacterium were found to be more abundant in the probiotic-treated group (P < 0.05). Salivary microbiota abundance and predicted functional profiling abundance correlations were found to be associated with anti-inflammation, anti-obesity, toxin degradation, and anti-oxidative injury effects (Q < 0.1). Several oral taxa also displayed correlations with social behavior severity scores in the probiotic-treated group (Q < 0.1). The findings suggest novel salivary microbiota compositional changes in response to the oral supplementation of BL-11 probiotic in individuals with PWS. The observed differentially abundant taxa between groups post-treatment were highly correlated with interventional effects on growth and social behaviors, although further investigation is warranted. Clinical Trial Registration The original clinical trial was registered under the Chinese Clinical Trial Registry with registration number ChiCTR1900022646 (April 20, 2019).
Competing voices: Indigenous rights in the shadow of conventional fisheries management in the tropical rock lobster fishery in Torres Strait, Australia
Authors: Lalancette Annie , Mulrennan Monica 
Published: April 2022

AbstractMuch progress has been made in recent decades in achieving high-level recognition of indigenous fishing rights. Despite these advances, actualization of indigenous rights to own and control marine resources has proven challenging. Insufficient attention to the centrality of power and its workings in fisheries are often the subject of critiques and of calls for more empirical research. This paper draws on interviews, participant observation, cognitive mapping, scenario workshops, and policy document review to examine power configurations and dynamics in the tropical rock lobster (TRL) fishery in Torres Strait (TS), Australia. Despite recognition of indigenous commercial fishing rights by the High Court in 2013, there have been only limited changes in how fisheries governance operates in the region. The current TRL management plan also risks entrenching non-indigenous interests in the fishery, thereby preventing Islanders from achieving their aspiration to fully own and control TS fisheries. Through an analysis drawing from Foucault’s theory of governmentality and Blaser’s political ontology framework, we show (1) how current fisheries management structures, processes and discourses are at odds with Islanders’ conceptions of the fisheries; and (2) how the existing regime excludes and renders silent Islander priorities. Our findings extend to indigenous-state relations in other state-managed fisheries. We believe our proposed conceptual framework can be useful in unveiling power relations that constrain indigenous rights and in identifying transformation options. We conclude that a sea change in conventional fisheries governance arrangements is needed to respond to new imperatives and expectations around indigenous fishing rights and interests.
Does a Hypertrophying Muscle Fibre Reprogramme its Metabolism Similar to a Cancer Cell?
Authors: Wackerhage Henning , Vechetti Ivan J. , Baumert Philipp , Gehlert Sebastian , Becker Lore , Jaspers Richard T. , de Angelis Martin Hrabě 
Published: April 2022

AbstractIn 1924, Otto Warburg asked “How does the metabolism of a growing tissue differ from that of a non-growing tissue?” Currently, we know that proliferating healthy and cancer cells reprogramme their metabolism. This typically includes increased glucose uptake, glycolytic flux and lactate synthesis. A key function of this reprogramming is to channel glycolytic intermediates and other metabolites into anabolic reactions such as nucleotide-RNA/DNA synthesis, amino acid-protein synthesis and the synthesis of, for example, acetyl and methyl groups for epigenetic modification. In this review, we discuss evidence that a hypertrophying muscle similarly takes up more glucose and reprogrammes its metabolism to channel energy metabolites into anabolic pathways. We specifically discuss the functions of the cancer-associated enzymes phosphoglycerate dehydrogenase and pyruvate kinase muscle 2 in skeletal muscle. In addition, we ask whether increased glucose uptake by a hypertrophying muscle explains why muscularity is often negatively associated with type 2 diabetes mellitus and obesity.
Students’ Development of a Logarithm Function in Python Using Taylor Expansions: a Teaching Design Case Study
Authors: Sand Odd Petter , Lockwood Elise , Caballero Marcos D. , Mørken Knut 
Published: April 2022

AbstractWe present here the lessons learned by iteratively designing a tutorial for first-year university students using computer programming to work with mathematical models. Alternating between design and implementation, we used video-taped task interviews and classroom observations to ensure that the design promoted student understanding. The final version of the tutorial we present here has students make their own logarithm function from scratch, using Taylor polynomials. To ensure that the resulting function is accurate and reasonably fast, the students had to understand and apply concepts both from computing and from mathematics. We identify three categories of such concepts and identify three design features that students attended to when demonstrating such understanding. Additionally, we describe four important take-aways from a teaching design point of view that resulted from this iterative design process.
Habitat quality assessment of mining cities based on InVEST model—a case study of Yanshan County, Jiangxi Province
Authors: Li Yanan , Duo Linghua , Zhang Ming , Yang Jingyuan , Guo Xiaofei 
Published: April 2022

AbstractThe assessment of the spatiotemporal evolution of habitat quality caused by land use changes can provide a scientific basis for the ecological protection and green development of mining cities. Taking Yanshan County as an example of a typical mining city, this article discussed the spatial pattern and evolution characteristics of habitat quality in 2000 and 2018 based on the ArcGIS platform and the InVEST model. The conclusions are as below: from 2000 to 2018, the area of farmland and construction land changed the most in the study area. Among them, the area of farmland decreased by 3.48%, and the area of industrial and mining land and construction land increased by 53.25%. Areas of low, relatively low and high habitat quality expanded, and areas of medium and relatively high habitat quality shrank, which is closely related to the distribution of land use. The areas with high habitat degradation degrees appear around cities, mining areas and watersheds, while the areas with low habitat degradation degrees are mainly distributed in the southern woodland. The distribution of cold and hot spots in the habitat quality distribution of Yanshan County presents a pattern of “hot in the south and cold in the north”. The results are of great significance to the precise implementation of ecosystem management decisions in mining cities and the creation of a landscape pattern of “beautiful countrysides, green cities, and green mines”.
The dynamics of multilevel administration. Coordination processes between national, supra- and international administrations in energy policy
Authors: Corcaci Andreas 
Published: April 2022

AbstractMultilevel governance of energy transitions depends on the coordination between national, supra- and international administrative actors. Coordination takes place in systems of multilevel administration, which constitute highly dynamic arenas dominated by legally non-binding instruments and reciprocal interactions and relationships. This article seeks to gain insights into the underlying coordination processes by asking which conditions account for the change over time of coordination between administrative actors in multilevel administration systems. First, research on multilevel administration is summarized. Second and starting from historic and discursive institutionalist theory, a conceptual framework is outlined to assess the conditions and modes that account for the dynamics of coordination in general, and the change of coordination instruments in particular. A trend towards persuasive coordination in a process of institutional layering driven by endogenous conditions is expected. Empirically, an in-depth comparative analysis is conducted based on exploratory interviews with 90 experts mainly from the European Commission, the International Energy Agency, and national administrators from Canada and Europe. The results unveil that administrative coordination evolves according to at least three types of layering that go beyond the initial hypothesis: first, through layering of coordination instruments; second, as an increase in formal and non-formal interactions through a growing number of channels and complexity of interactions over time; third, as layering of inter-administrative relationships through a growing importance of personal networks and the creation of new contacts. By analysing the dynamics of multilevel administrative coordination, the article contributes to an important but underdeveloped aspect of the governance of supra- and international energy transitions.
Effects of Working Memory Training on Children’s Memory and Academic Performance: the Role of Training Task Features and Trainee’s Characteristics
Authors: Studer-Luethi Barbara , Toermaenen Minna , Margelisch Katja , Hogrefe Antonia B. , Perrig Walter J. 
Published: April 2022

Abstract
Learning and academic performance are explained mainly by basic limited-capacity processes, most notably by working memory (WM). Consequently, training WM has been considered a promising approach to fostering these abilities. However, school-based investigations are rare. This study examined the effects of training task features and trainees’ characteristics on transfer to cognitive and academic measures. Eighty-six typically developing 8–12-year-old children completed 6 weeks of either WM training with n-back and complex span tasks or a control training with perceptual-matching tasks in a regular school setting. The study also assessed some personal variables of the children, such as neuroticism, conscientiousness, joy of learning, and power of endurance. The WM training group showed increased WM and math performance compared to the control group. Also, there was a trend toward some improvements in vocabulary after WM training, and overall improvements after both trainings were observed in fluid intelligence and reading. Analyses of individual differences in the WM training group indicated increased training performance in relation to emotional stability, conscientiousness, power of endurance, as well as teacher-reported joy of learning and social integration of participants. Thus, the results indicate the potential of WM training to improve WM capacity and mathematical skills and reveal the impact of regulative, motivational, and social factors on cognitive training performance.
Quantifying light energy from 450 nm, 650 nm, 810 nm, and 980 nm wavelength lasers delivered through dental hard tissue
Authors: Chan Alex Simon , Chan Adam G. , Dawes Judith M. , Chan Andrew Jonathan , Chan Ambrose 
Published: April 2022

Abstract

Purpose
The energy available to treat the dental pulp after transmittance through overlying structures is clinically important for determining photobiological effects. This ex vivo study aimed to quantify laser energy delivery though the dental crown to the pulp from an initial energy of 5 J using four common laser wavelengths (λ = 450, 650, 810, and 980 nm).

Material and methods
A total of 30 extracted healthy human teeth (anterior n = 10; premolar n = 10; molar n = 10) were longitudinally sectioned (Project Number: 2021/421, University of Sydney, NSW, Australia). Each sample was methodically exposed in random order to the four wavelengths. Each wavelength was operated at the same power (0.50 W) for 10 s to deliver 5.0 J with a total energy delivery of 10 J/cm2. Laser light was delivered with an 8-mm-diameter fiber bundle probe directed perpendicularly to the buccal cervical-third of the crown. The transmitted energy was measured twice and averaged using a periodically pre-calibrated power meter in blinded conditions. Data were analyzed using a general linear model with logarithmic transformation.

Results
Wavelength and tooth thickness were significant predictors of optical transmittance (P < 0.05) while tooth type was significant only for the 450 nm wavelength. The average attenuation coefficients (µ) were 2.55, 2.45, 1.87, and 5.42 cm−1 (± 10%) for the 980, 810, 650, and 450 nm groups, respectively.

Conclusion
Clinicians should recognize that significant attenuation occurs during laser energy delivery to the pulp, influenced by the wavelength, thickness, and tooth type. Our findings support the potential for laser energy delivery to the pulp for photobiomodulation applications.
Two sides of the same leader: an agent-based model to analyze the effect of ambivalent opinion leaders in social networks
Authors: Röchert Daniel , Cargnino Manuel , Neubaum German 
Published: April 2022

AbstractOpinion leaders (OLs) are becoming increasingly relevant on social networking sites as their visibility can help to shape their followers’ attitudes toward a variety of issues. While earlier research provided initial evidence on the effect of OLs using agent-based modeling, it remains unclear how OLs affect their network environment and, therefore, the opinion climate when: (a) they publicly hold ambivalent attitudes, and (b) they not only express support for their own stance but also discredit or ‘debunk’ the opposing side. This paper presents an agent-based model that determines the influence of OLs in social networks in relation to ambivalence and discreditation. The model draws on theoretical foundations of OLs as well as attitudinal ambivalence and was implemented using two network topologies. Results indicate that OLs have significant influence on the opinion climate and that an unequal number of OLs of different opinion camps lead to an imbalance in the opinion climate only in certain situations. Furthermore, OLs can dominate the opinion climate and turn their stance into a majority opinion more effectively when discrediting the opposing side. Ambivalent OLs, on the other hand, can contribute to greater balance in the opinion climate. These findings provide a more nuanced analysis of OLs in social networks by pointing to potential amplifications as well as boundaries of their influence. Implications are discussed with a focus on human and artificial key actors in online networks and their efficacy therein.
21 Ectopic Reservoir Placement Following Robotic Prostatectomy: Is it Necessary?
Authors: Denison C , Westerman ME , Mutter M 
Published: April 2022

ABSTRACT

Introduction
Traditional robotic-assisted radical prostatectomy (RARP) disrupts the space of retzius (SoR) and may result in small bowel injury with traditional SoR reservoir placement during 3-piece penile prosthesis placement. Given this, ectopic reservoir placement is a widely accepted practice in patients who have undergone prior non-retzius sparing robotic-assisted radical prostatectomy, despite potential for herniation and palpability of the reservoir.

Objective
Reservoir placement in the traditional space of retzius (SoR) is generally avoided in post RARP patients due to concern of bowel injury. Our aim is to evaluate the incidence of incidental small bowel found in the space of retzius after RARP utilizing post surgical imaging. Secondarily, we aimed to evaluate the proximity of small bowel to the pubis in this population.

Methods
434 men who underwent RARP in our department between 01/2012 and 09/2020 were eligible for inclusion. We identified 162 men with cross sectional imaging available after RARP. For men with multiple scans, the most recent was used. Of these, men whose imaging was within one month of surgery or who had complicating factors such as post-operative drains were excluded (n=42). The primary endpoint was identification of bowel posterior to the midline of the pubic symphysis (figure 1). In cases without bowel found in the SoR, distance from the superior aspect of the pubis to the closest bowel loop was recorded (figure 2). Measurements were taken in either the sagittal or axial dimensions. Patient demographic and surgical features were evaluated to determine if there was an association among patients with bowel found in the SoR.

Results
120 men were eligible for inclusion. The mean time from RARP to imaging was 19.4 months. In total, 8/120 (6.6%) men had intra-abdominal contents within the SoR. For men without bowel in the SoR, the mean distance from bowel to the superior aspect of the pubis was 3.81cm. The most common finding among majority of patients (7/8) with bowel found in SoR was a decompressed urinary bladder at the time of imaging.

Conclusions
Based on our observations, penile prosthesis reservoir placement in the SoR can be safely performed, with respect to potential bowel injury in the majority of patients who have undergone prior non-retzius sparing RARP. Cross sectional imaging may be obtained prior to implantation to evaluate for the presence of bowel within the SoR and to guide reservoir placement. Further research evaluating the location of bowel pre- and post-RARP as well as whether this is static or changeable is ongoing.

Disclosure
No