bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of frailty with outcomes of resection for colonic volvulus: A national analysis
Authors: Ebrahimian Shayan , Lee Cory , Tran Zachary , Sakowitz Sara , Bakhtiyar Syed Shahyan , Verma Arjun , Tillou Areti , Benharash Peyman , Lee Hanjoo 
Published: November 2022

Background
With limited national studies available, we characterized the association of frailty with outcomes of surgical resection for colonic volvulus.

Methods
Adults with sigmoid or cecal volvulus undergoing non-elective colectomy were identified in the 2010–2019 Nationwide Readmissions Database. Frailty was identified using the Johns Hopkins indicator which utilizes administrative codes. Multivariable models were developed to examine the association of frailty with in-hospital mortality, perioperative complications, stoma use, length of stay, hospitalization costs, non-home discharge, and 30-day non-elective readmissions.

Results
An estimated 66,767 patients underwent resection for colonic volvulus (Sigmoid: 39.6%; Cecal: 60.4%). Using the Johns Hopkins indicator, 30.3% of patients with sigmoid volvulus and 15.9% of those with cecal volvulus were considered frail. After adjustment, frail patients had higher risk of mortality compared to non-frail in both sigmoid (10.6% [95% CI 9.47–11.7] vs 5.7% [95% CI 5.2–6.2]) and cecal (10.4% [95% CI 9.2–11.6] vs 3.5% [95% CI 3.2–3.8]) volvulus cohorts. Frailty was associated with greater odds of acute venous thromboembolism occurrences (Sigmoid: AOR 1.50 [95% CI 1.18–1.94]; Cecal: AOR 2.0 [95% CI 1.50–2.72]), colostomy formation (Sigmoid: AOR 1.73 [95% CI 1.57–1.91]; Cecal: AOR 1.48 [95% CI 1.10–2.00]), non-home discharge (Sigmoid: AOR 1.97 [95% CI 1.77–2.20]; Cecal: AOR 2.56 [95% CI 2.27–2.89]), and 30-day readmission (Sigmoid: AOR 1.15 [95% CI 1.01–1.30]; Cecal: AOR 1.26 [95% CI 1.10–1.45]). Frailty was associated with incremental increase in length of stay (Sigmoid: +3.4 days [95% CI 2.8–3.9]; Cecal: +3.8 days [95% CI 3.3–4.4]) and costs (Sigmoid: +$7.5k [95% CI 5.9–9.1]; Cecal: +$12.1k [95% CI 10.1–14.1]).

Conclusion
Frailty, measured using a simplified administrative tool, is associated with significantly worse clinical and financial outcomes following non-elective resections for colonic volvulus. Standard assessment of frailty may aid risk-stratification, better inform shared-decision making, and guide healthcare teams in targeted resource allocation in this vulnerable patient population.
Subclinical hypothyroidism and digit span test performance in children: a systematic review and meta-analysis
Authors: Surya Nadhea Debrinita , Widjanarko Nicolas Daniel , Permatasari Theressa Kristiayu , Yosephine Yuliana , Wijaya Ellen 
Published: November 2022

Background The digit span (DS) test is one of the most commonly used neuropsychological tests to assess certain cognitive domains, i.e., short-term verbal memory, working memory, and attention. Subclinical hypothyroidism (SH) may be associated with a risk of cognitive impairment in children and adolescents.
Objective To evaluate the association between SH and DS test performance in children.
Methods Eligible studies evaluating SH and DS test performance were included in this systematic review and further assessed for risk of bias using the Newcastle Ottawa Scale. We carried out a meta-analysis using the random effects model to determine mean difference with 95% confidence interval (95%CI) for continuous data. This systematic review was conducted according to the Preview Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement.
Results Out of 1,511 participants in the five included studies, 129 had SH and 1,382 were euthyroid. The quality of all studies were fair to good. Three studies were extracted for meta-analysis, with results showing a trend toward a poorer DS test performance in the SH group compared to controls, although this difference was statistically insignificant (IV -0.57; 95%CI -1.61 to 0.46; P=0.28). There was no significant heterogeneity among the included studies (I2=0%; P=0.69).
Conclusion No significant association was noted between SH and the domains of cognitive function assessed using the DS test. Several intrinsic and extrinsic factors and inability of the DS test to detect subtle impairment may limit its usefulness in children.
Asymptotically Mean Value Harmonic Functions in Doubling Metric Measure Spaces
Authors: Adamowicz Tomasz , Kijowski Antoni , Soultanis Elefterios 
Published: November 2022

AbstractWe consider functions with an asymptotic mean value property, known to characterize harmonicity in Riemannian manifolds and in doubling metric measure spaces. We show that the strongly amv-harmonic functions are Hölder continuous for any exponent below one. More generally, we define the class of functions with finite amv-norm and show that functions in this class belong to a fractional Hajłasz–Sobolev space and their blow-ups satisfy the mean-value property. Furthermore, in the weighted Euclidean setting we find an elliptic PDE satisfied by amv-harmonic functions.
Manufacturing operations as services by robots with skills
Authors: Heikkilä Tapio , Pakkala Daniel , Seppälä Tuomas , Kotaniemi Jarkko , Pääkkönen Pekka , Saukkoriipi Janne , Niskanen Ilkka 
Published: November 2022

Abstract
This work considers flexible manufacturing operations based on reconfigurable robotic skills and their usage in fully automated service manufacturing. In agile and ultra-flexible manufacturing operations, where lot sizes go down to one, the setup and execution of new tasks must be instant. We extend service manufacturing towards applications of multi-purpose autonomous mobile robots. We take digital data and service-oriented approach to configure and utilize re-usable robot operations formulated as robot skills. We integrate service requests, and system and robot skill models for an easily executable manufacturing service system. We show the feasibility of our approach by experimental tests with merged indoor logistics, assembly, and finishing tasks.
Size-dependent growth kinetics model for potassium chloride from seeded chloride solution
Authors: Zheng Dan , Wang Jiao , Shen Yueqiu , Yang Meihui , Xu Menglin , Ma Yulan , Tian Yongqi , Wu Xieping 
Published: November 2022

Abstract
It was widely known that crystallization kinetics are the basis for crystallization behavior and crystallizer scale-up design. Cooling crystallization of potassium chloride was an essential unit operation in recycling industry. Some researchers have proposed the strategy of adding seed crystals for the intermittent cooling crystallization process to control the particle size and distribution of the target product. This paper studied the complex function relation between particle size and growth rate of KCI in the crystallization process in a continuous mixed-suspension mixed-product-removal (MSMPR) crystallizer at a steady state. Using the crystallization kinetics data, the mathematical models of coupling crystallization were established based on the population balance equations and mass balance equations. Since population density distributions of products behave multiform under different conditions, based on diffusion theory. The growth rate was obtained by a least square method for the multivariate linear regression, and the reliability of the kinetics model was validated experimentally. Fitting results indicated that some classical models, including several size-independent growth models and size-dependent growth models, such as Bransom, C-R, MJ2, ASL, and MJ3, could not model the size-dependent growth accurately. Based on this situation, an exponential growth model was proposed and confirmed to describe the size-dependent growth behavior. It was found that the model parameters have definite meanings and were strongly related to particle size. Compared with the classical models, this model showed good pertinency and adaptability to experimental results when used to describe the population density distribution and the size-dependent growth rate of KCI. This research could provide a theoretical guide for optimizing the crystallization process and designing industrial crystallizers.
Implementation of a polarization-encoded quantum CNOT gate
Authors: Samanta Debajyoti 
Published: November 2022

Abstract
Optics has been successfully used for data processing. The basic building blocks of quantum computers are the quantum gates. Here, a quantum CNOT gate is proposed. To implement the gate advantages of polarization-based encoding technique and optical Kerr material-based switching are utilized. CS2 can show this type of switching feature. An Nd-YAG laser source of 1.064 μm wavelength is used to implement the scheme. Intensity of the laser pulse should be of the order of 1018 W/m2 to excite the 2nd order nonlinearity of the isotropic nonlinear material.
An optimal design of GNSS interference localisation wireless security network based on time-difference of arrivals for the Arlanda international airport
Authors: Eshagh Mehdi 
Published: November 2022

AbstractToday, most of the aircrafts are navigated by global navigation satellite systems (GNSSs). Landing is a dangerous phase of a flight especially when an airport runway is not clearly seen from the aircrafts. In such cases, GNSSs are useful for a safe landing under the circumstances that healthy signals, free of any interference, reach to GNSSs receiver antennas mounted on the aircrafts. This shows the importance of establishing GNSS interference localisation security networks around airports. Designing a good configuration for the points with GNSS antennas at for receiving interference signals is important for a successful localisation of the interference device. Here, the time-difference of the arrivals of an interference signal to such points or anchor nodes (ANs), are used as observables, and a security network with four ANs is optimally designed along the runways of the Arlanda airport to reduce the dilution of precision (DOP) of the network. Our study showed that by such an optimisation, the maximum DOP value can reduce by 50% meaning a significant increase in the probability of a successful interference device localisation.
In silico ADMET, molecular docking study, and nano Sb2O3-catalyzed microwave-mediated synthesis of new α-aminophosphonates as potential anti-diabetic agents
Authors: Altaff Shaik Mohammad , Rajeswari Tiruveedula Raja , Subramanyam Chennamsetty 
Published: November 2022

Abstract
An efficient and greener method is developed for the synthesis of α-aminophosphonates via Kabachnik–Fields reaction in solvent free condition using microwave irradiation technique. For all of the compounds, an in silico ADMET and molecular docking study was conducted to get insight on the drug likeliness behavior as well as their ability to block the enzyme α-amylase. The compounds with significant binding affinity and significant pharmacokinetic characteristics were produced. The newly produced compounds were spectroscopically analyzed to confirm their structure, and in vitro α-amylase inhibitory activity was also tested for all of them. The compounds 8j (half-maximal inhibitory concentration (IC50), 100.5 ± 0.2 μg·mL−1) showed better inhibitory activity than the reference drug, acarbose. The compounds 8d (IC50, 108.6 ± 0.2 μg·mL−1), 8g (IC50, 110.9 ± 0.3 μg·mL−1), 8h (IC50, 115.0 ± 0.1 μg·mL−1), and 8f (IC50, 118.9 ± 0.2 μg·mL−1) have been reported to exhibit significant inhibition toward the target enzyme. All the leftover compounds displayed modest to excellent inhibition through IC50 values in the range from 122.3 ± 0.3 to 154.3 ± 0.6 μg·mL−1 while comparing with the reference drug, Acarbose (IC50, 103.2 ± 0.7 μg·mL−1). The results disclosed that the majority of these compounds exhibit significant α-amylase inhibitory activity.
Folate receptor genes were up-regulated in epithelial ovarian cancer and partly associated with patients’ prognosis
Authors: Yang Juanli , Tang Zheng , Ma Yan , Dong Weilei , Luo Guifang , Yu Furong , Jiang Feng , Wang Xiaolan , Liao Wenyan 
Published: November 2022

Abstract

Objective
The present work aimed to investigate folate receptor (FOLR1, FOLR2, FOLR3) expression, functional enrichment, signaling pathway and prognosis in ovarian cancer patients by integrated bioinformatics analysis.

Methods
Folate receptor (FOLR1, FOLR2, and FOLR3) mRNA expression level between epithelial ovarian cancer and corresponding normal ovarian tissue of cancer patients was compared through the TCGA database by GEPIA online analysis tool. The protein–protein interaction (PPI) network of FOLR1, FOLR2, FOLR3, and related genes were constructed through the STRING database. GO and KEGG enrichment of FOLR1, FOLR2, FOLR3, and relevant genes were analyzed. Overall survival (OS) and progression-free survival (PFS) between FOLR1, FOLR2, and FOLR3 mRNA high and low expression epithelial ovarian cancer patients were compared by log-rank test.

Results
FOLR and FOLR3 mRNA expression in epithelial ovarian cancer tissue were significantly higher than that of corresponding normal ovarian tissue of cancer patients (P < 0.05) The PPI network showed 53 nodes and 298 edges with the average node degree of 11.2. The local clustering coefficient was 0.744, which indicated that the protein–protein enrichment was statistically significant (P < 1.0 × 10−16). Folate receptor (FOLR1, FOLR2, and FOLR3) and relevant genes were mainly enriched in folic acid transport, methotrexate transmembrane transporter activity, antifolate resistance for biological process, molecular function, and KEGG pathway, respectively. The PFS of FOLR1 and FOLR3 high expression epithelial ovarian cancer patients was significantly lower compared to low-expression subjects with statistical significance [hazard ratio (HRFOLR1) = 1.26, 95% confidence interval (CI): 1.09–1.45, P < 0.05, HRFOLR3 = 1.22, 95% CI: 1.06–1.40, P < 0.05]. However, the OS was not statistically different between FOLR1, FOLR2, and FOLR3 low and high expression groups.

Conclusion
Folate receptor (FOLR1, FOLR2, and FOLR3) genes were up-regulated in epithelial ovarian cancer and partly associated with patient’s poor prognosis.
Racial and Ethnic Differences in Communication Quality During Family-Centered Rounds
Authors: Parente Victoria M. , Reid Hadley W. , Robles Joanna , Johnson Kimberly S. , Svetkey Laura P , Sanders Linda L. , Olsen Maren K. , Pollak Kathryn I. 
Published: November 2022

OBJECTIVES
To evaluate racial and ethnic differences in communication quality during family centered rounds.

METHODS
We conducted an observational study of family-centered rounds on hospital day 1. All enrolled caregivers completed a survey following rounds and a subset consented to audio record their encounter with the medical team. We applied a priori defined codes to transcriptions of the audio-recorded encounters to assess objective communication quality, including medical team behaviors, caregiver participatory behaviors, and global communication scores. The surveys were designed to measure subjective communication quality. Incident Rate Ratios (IRR) were calculated with regression models to compare the relative mean number of behaviors per encounter time minute by race and ethnicity.

RESULTS
Overall, 202 of 341 eligible caregivers completed the survey, and 59 had accompanying audio- recorded rounds. We found racial and ethnic differences in participatory behaviors: English-speaking Latinx (IRR 0.5; 95% confidence interval [CI] 0.3–0.8) Black (IRR 0.6; 95% CI 0.4–0.8), and Spanish-speaking Latinx caregivers (IRR 0.3; 95% CI 0.2–0.5) participated less than white caregivers. Coder-rated global ratings of medical team respect and partnership were lower for Black and Spanish-speaking Latinx caregivers than white caregivers (respect 3.1 and 2.9 vs 3.6, P values .03 and .04, respectively: partnership 2.4 and 2.3 vs 3.1, P values .03 and .04 respectively). In surveys, Spanish-speaking caregivers reported lower subjective communication quality in several domains.

CONCLUSIONS
In this study, Black and Latinx caregivers were treated with less partnership and respect than white caregivers.
Історична ретроспектива селекційної роботи з амарантом в Україні (80–90-ті рр. ХХ ст.)
Authors: Грюнвальд Наталія 
Published: November 2022

Стаття присвячена розгляду історії введення в культуру маловідомої стародавньої рослини амарант, продукти переробки якої вирізняються унікальними, біологічно цінними властивостями. На основі джерелознавчого аналізу та використання предметно-хронологічного і описового методів розкрито окремі біологічні і фізіологічні характеристики, генетичні особливості поширення і започаткування системної селекційної роботи з культурою амаранту.
Мета дослідження полягає у висвітленні історичних аспектів селекційних досліджень з амарантом упродовж 80–90-х рр. ХХ ст. в Україні з побіжним відображенням особливостей маловідомої але перспективної культури.
Встановлено, що у зв’язку з потребою урізноманітнення зернових культур, збільшення їх сортового і видового асортименту, на початку 1980-х років учені активізували дослідження колекційного фонду та селекції амаранту з огляду на високий вміст поживних речовин, стійкість до посухи та невибагливість до ґрунту. Низкою установ, що в подальшому стануть центрами вивчення амаранту, поряд із добором і випробуванням перспективних видів та вивченням продуктивного потенціалу сортозразків, розпочалось створення нових сортів амаранту кормового і зернового типів. З’ясовано, що одним із перших вітчизняних сортів став Донецький 1, виведений шляхом вільного перезапилення 2-х дикорослих екотипів та 3-х культурних видів амаранту з подальшим відбором потужних гібридного типу рослин. Кількарічні випробування довели його посухостійкість, здатність до стабільно високої урожайності зеленої маси та зерна. Активізація селекційної роботи з амарантом сприяла створенню у досліджуваний період восьми сортів амаранту, зокрема Стерх (Національний ботанічний сад імені М.М. Гришка НАН України), Ультра (Харківський національний аграрний університет ім. В. В. Докучаєва), Атлант (Інститут кормів та сільського господарства Поділля НААН) та ін. У селекції амаранту найчастіше застосовували метод міжсортової та міжвидової гібридизації з подальшими індивідуально-сімейними і сімейно-груповими відборами. Новостворені сорти вирізнялися невибагливістю до ґрунтів, стійкістю до хвороб, адаптованістю до різних умов, а також високою насіннєвою і вегетативною продуктивністю.
Філософія міжнародного космічного права: концептуальні горизонти проблемного поля
Authors: Шевцов Сергій 
Published: November 2022

Актуальність теми обумовлена необхідністю розробки філософських підвалин міжнародного космічного права, які суттєво відрізняються від теорії міжнародного космічного права власним метатеоретичним статусом. Метою є артикуляція бачення філософії міжнародного космічного права у якості служниці або метатеоретичного підґрунтя міжнародного космічного права та окреслення її предметного кола.
Результатами дослідження є відокремлення теорії та філософії міжнародного космічного права і демонстрація її наступних метатеоретичних підвалин: по-перше, філософії права та філософії міжнародного права у якості парадигмальних праксеологічних, по-друге, концепту людина космічна (homo cosmicus) як філософсько-антропологічної, по-третє, ідей комунікативного розуму К.-О. Апеля й Ю. Габермаса, відповідальності Г. Йонаса, справедливості Дж. Ролза як аксіологічної, по-четверте, космічності, холістичності, синергійності у якості світоглядної, по-п’яте, екологічні імперативи у вигляді максим як екзистенціально-прогностичної.
У висновках наведено, що теорія та філософія міжнародного космічного права мають різні предметні поля: якщо перша спрямована на опис, аналіз, тлумачення ключових понять міжнародного космічного права, то друга розглядає його як культурно-онтологічний феномен, який виникає під впливом певних екзистенціально-аксіологічних викликів, співвідноситься з трансцендентними цілями культури, базується на образі людини як космічної істоти, сходить до актуальних сучасних концепцій праксеологічної спрямованості. З’ясовано, що предметне коло філософії міжнародного космічного права встановлює низка зрізів: перший – парадигмальний, який задає концептуальні умови становлення цієї галузі наукового знання; другий – філософсько-антропологічний, де ідея людини космічної символізує основну інтуїцію, а також спрямованість розвитку людства у майбутньому; третій – аксіологічний, оскільки поза ціннісним виміром неможливо розв’язувати складні правові стосунки між різними державами – суб’єктами космічної діяльності; четвертий – світоглядний, де інтуїції космічності, холістичності, синергійності є визначальними; п’ятий – екзистенціально-прогностичний, оскільки засвоєння космосу має загальнолюдський характер і несе відповідальність перед майбутнім.
small-flowered <i>Cyrtochilum</i> (Oncidiinae) from Colombia
Authors: Ordóñez-Blanco Juan Camilo , Parra-Sánchez Edicson 
Published: November 2022

A new species of Cyrtochilum from the Cordillera Oriental range in the department of Cundinamarca, Colombia, is described, illustrated, and compared with C. suarezii and C. parviflorum. The new species is easily distinguished by its broadly elliptic to sub–rhomboid lip with two short rounded simple calli on the lip, ornamented with short papillae at the base.
A formação docente: que lugar ocupa na inserçao do professor nas escolas técnicas da área da saúde?
Authors: Corrêa Adriana Katia 
Published: November 2022

Introdução: A educação profissional técnica de nível médio (EPTNM) é muito presente na área da saúde, considerando o grande contingente de trabalhadores técnicos, todavia, há políticas frágeis quanto à formação de professores. Objetivos: 1. analisar quais são os critérios e as formas de seleção, no que se refere à exigência da formação como professor; 2. relacionar a formação de professores com alguns aspectos das relações/condições de trabalho. Metodologia: estudo com enfoque histórico-dialético, envolvendo pesquisa documental e de campo. Participaram 10 escolas que ofertam cursos técnicos da área da saúde, sendo cinco públicas e cinco privadas, no estado de São Paulo, contemplando unidades das ETECs - Centro Paula Souza, ETSUS, SENAC e outras escolas da rede privada, do interior e da capital. Feita análise de planos de cursos, questionários on line e entrevistas semiestruturadas com gestores e entrevistas semiestruturadas com professores. Conclusões: Apesar da maioria dos planos de cursos e dos gestores indicarem, prioritariamente, a seleção de docentes com licenciatura, programas especiais ou outras vias de formação pedagógica, há sempre um caráter dúbio, incerto e de extrema flexibilidade. A formação flexibilizada e fragilizada para a docência na EPTNM contribui com a naturalização e o fortalecimento dos aspectos que convergem para a precarização do trabalho, o que precisa ser contextualizado, historicamente, nas relações entre a educação e os processos mais amplos de reprodução da sociedade capitalista atualmente marcados pelo ideário neoliberal.