bluuebunny/crossref_metadata_2025_split huggingface dataset:
Community-scale big data reveals disparate impacts of the Texas winter storm of 2021 and its managed power outage
Authors: Lee Cheng-Chun , Maron Mikel , Mostafavi Ali 
Published: September 2022

AbstractAggregated community-scale data could be harnessed to provide insights into the disparate impacts of managed power outages, burst pipes, and food inaccessibility during extreme weather events. During the winter storm that brought historically low temperatures, snow, and ice to the entire state of Texas in February 2021, Texas power-generating plant operators resorted to rolling blackouts to prevent collapse of the power grid when power demand overwhelmed supply. To reveal the disparate impact of managed power outages on vulnerable subpopulations in Harris County, Texas, which encompasses the city of Houston, we collected and analyzed community-scale big data using statistical and trend classification analyses. The results highlight the spatial and temporal patterns of impacts on vulnerable subpopulations in Harris County. The findings show a significant disparity in the extent and duration of power outages experienced by low-income and minority groups, suggesting the existence of inequality in the management and implementation of the power outage. Also, the extent of burst pipes and disrupted food access, as a proxy for storm impact, were more severe for low-income and minority groups. Insights provided by the results could form a basis from which infrastructure operators might enhance social equality during managed service disruptions in such events. The results and findings demonstrate the value of community-scale big data sources for rapid impact assessment in the aftermath of extreme weather events.
Qualitative properties for solutions to subcritical fourth order systems*
Authors: Andrade João Henrique , Do Ó João Marcos 
Published: September 2022

Abstract
We prove some qualitative properties for singular solutions to a class of strongly coupled system involving a Gross–Pitaevskii-type nonlinearity. Our main theorems are vectorial fourth order counterparts of the classical results due to Serrin (1964 Acta Math. 111 247–252), Lions (1980 J. Differ. Equ.
38 441–450), Aviles (1987 Commun. Math. Phys.
108 177–192), and Gidas and Spruck (1981 Commun. Pure Appl. Math.
34 525–598). On the technical level, we use the moving sphere method to classify the limit blow-up solutions to our system. Besides, applying asymptotic analysis, we show that these solutions are indeed the local models near the isolated singularity. We also introduce a new fourth order nonautonomous Pohozaev functional, whose monotonicity properties yield improvement for the asymptotics results due to Soranzo (1997 Potential Anal.
6 57–85).
Some generic properties of partially hyperbolic endomorphisms*
Authors: Costa J S C , Micena F 
Published: September 2022

Abstract
In this work, we deal with a notion of partially hyperbolic endomorphism. We explore topological properties of this definition and we obtain, among other results, obstructions to get center leaf conjugacy with the linear part, for a class of partially hyperbolic endomorphism C
1-sufficiently close to a hyperbolic linear endomorphism. Indeed such obstructions are related to the number of center directions of a point. We provide examples illustrating these obstructions. We show that for a manifold M with dimension n ⩾ 3, admitting a non-invertible partially hyperbolic endomorphisms, there is a C
1 open and dense subset

U

of all partially hyperbolic endomorphisms with degree d ⩾ n, such that any

f
∈
U

is neither c nor u special.
Implications of the cosmic birefringence measurement for the axion dark matter search
Authors: Obata Ippei 
Published: September 2022

Abstract
We show that a recent constraint on the cosmic birefringence effect due to dark energy can
be related to the constraints on the coupling of axion dark matter to photon, by relying on a
simple model of two-axion alignment mechanism with periodic potentials. Owing to the alignment of
the potentials, one linear combination of two fields provides a nearly flat direction and acts as
dark energy, whereas the other combination provides a steep direction and acts as dark matter.
This scenario solves the known conceptual issues of one-field model for dark energy and predicts
the connection between seemingly disparate constraints on the dark sectors of our universe.
Evolution of black holes through a nonsingular cosmological bounce
Authors: Corman Maxence , East William E. , Ripley Justin L. 
Published: September 2022

Abstract
We study the classical dynamics of black holes during a nonsingular cosmological bounce.
Taking a simple model of a nonsingular bouncing cosmology driven by the combination of a ghost and
ordinary scalar field, we use nonlinear evolutions of the Einstein equations to follow rotating
and non-rotating black holes of different sizes through the bounce. The violation of the null
energy condition allows for a shrinking black hole event horizon and we find that for sufficiently
large black holes (relative to the minimum Hubble radius) the black hole apparent horizon can
disappear during the contraction phase. Despite this, we show that most of the local cosmological
evolution remains largely unaffected by the presence of the black hole. We find that,
independently of the black hole's initial mass, the black hole's event horizon persists throughout
the bounce, and the late time dynamics consists of an expanding universe with a black hole of mass
comparable to its initial value.
Axion and FIMP dark matter in a 𝖴(1) extension of the Standard Model
Authors: Covi Laura , Khan Sarif 
Published: September 2022

Abstract
In the Standard Model a Dark Matter candidate is missing, but it is relatively
simple to enlarge the model including one or more suitable particles.
We consider in this paper one such extension, inspired by simplicity and
by the goal to solve more than just the Dark Matter issue.
Indeed we consider a local U(1) extension of the SM providing an
axion particle to solve the strong CP problem and including RH neutrinos
with appropriate mass terms. One of the latter is decoupled from the SM
leptons and can constitute stable sterile neutrino DM.
In this setting, the PQ symmetry arises only as an accidental symmetry
but its breaking by higher order operators is sufficiently suppressed to
avoid introducing a large θ contribution.
The axion decay constant and the RH neutrino masses are related
to the same v.e.v.s and the PQ scale and both DM densities are determined by
the parameters of the axion and scalar sector.
The model predicts in general a mixed Dark Matter
scenario with both axion and sterile neutrino DM and is characterised by
a reduced density and observational signals from each single component.
Mechanism of controlling robust and stable charging of open quantum batteries
Authors: Behzadi N , Kasani H 
Published: September 2022

Abstract
Quality of charging and discharging of energy in quantum batteries are mostly affected by environmental dissipations, so the advantages of using such devices depend on the protection of them from the dissipations. In this work, we show that under a certain engineering of coupling strengths of each reservoir modes with elements of charging process (charger and battery), the extension of dissipative reservoir leads to a robust charging against the arisen dissipation. The extension of reservoir is provided by auxiliary systems each of which is similar to the coupled charger–battery system and has the same interactions with the reservoir modes as of the charger and battery constituents. It is demonstrated that the robustness of charging process is well controlled by the number of involved auxiliary systems. Furthermore, a method for stable charging is proposed which provides storing energy in a loss-free dark state of the battery. Also, we observe that the robustness of charging process is related to formation of bound state for the total system (charger–battery-extended reservoir) which in turns can be manipulated by the number of involved auxiliary systems.
Bulk moduli of two-dimensional Yukawa solids and liquids obtained from periodic compressions
Authors: LU Shaoyu , HUANG Dong , SHAHZAD A , FENG Yan 
Published: September 2022

Abstract
Langevin dynamical simulations are performed to determine the bulk modulus in two-dimensional (2D) dusty plasmas from uniform periodic radial compressions. The bulk modulus is calculated directly from its physical definition of the ratio of the internal pressure/stress to the volume strain. Under various conditions, the bulk moduli obtained agree with the previous theoretical derivations from completely different approaches. It is found that the bulk moduli of 2D Yukawa solids and liquids are almost independent of the system temperature and the external compressional frequency.
Role of harvest depth filtration in controlling product-related impurities for a bispecific antibody
Authors: Espah Borujeni Ehsan , Jin Weixin , Shao Chun , Chennamsetty Naresh , Xu Xuankuo , Ghose Sanchayita 
Published: September 2022

Abstract

Background
Bispecific antibodies (BsAb) belong to a novel antibody category with advantages over traditional mono-specific therapeutic antibodies. However, product variants are also commonly seen during the production of BsAb, which poses significant challenges to downstream processing. In this study, the adsorptive characteristics of a BsAb product and its variants were investigated for a set of depth filters during primary recovery of the cell culture fluid.

Methods
The retention of the BsAb product and its variants on a set of Millistak+® D0HC and X0HC depth filters were first investigated, followed by studying the mechanism of their adsorption on the depth filters. The chemical and structural properties of depth filters along with the molecular properties of the product and its variants were studied subsequently.

Results
The X0HC filter was found to be able to retain a significant amount of low molecular weight (LMW) variants along with a low amount of main product retained. Different levels of retention, observed for these variants, were correlated to their different hydrophobic and charge characteristics in relation with the adsorptive properties of the depth filters used. Electrostatic, hydrophobic, and hydrogen bonding interactions were found to be the key forces to keep product variants retained on the depth filter where the higher hydrophobicity of the LMW variants may cause them to be preferentially retained.

Conclusion
Harvest depth filters potentially can be utilized for retaining the BsAb variants, which depends on relative molecular properties of the product and its variants and adsorptive properties of the depth filters used.
Functional Outcomes, Injury Variables, and Athlete Characteristics Associated with Post-Concussion Sleep Disturbance
Authors: Riegler Kaitlin E , Guty Erin T , Thomas Garrett A , Bradson Megan L , Arnett Peter A 
Published: September 2022

AbstractObjectiveTo examine the relationship between sleep disturbance and functional outcomes following a concussion. Also, to explore athlete and injury-related variables that may be related to risk factors for poor sleep following concussion.Method124 collegiate athletes completed a neuropsychological evaluation within 14 days of sustaining a sport-related concussion (SRC). Athletes were categorized as sleep disturbed (n = 52) or not sleep disturbed (n = 72). Outcome variables included symptom reports, cognitive performance (mean performance and variability), and mood (depression). Injury characteristics and athlete characteristics explored were loss of consciousness (LOC) associated with the injury, whether the athlete was immediately removed from play, and history of prior concussions.ResultsSleep disturbed athletes reported more symptoms, F(4, 119) = 7.82, p &lt; 0.001, ƞ2 = 0.21, were more likely to be symptomatic at the time of testing, χ2(1, N = 124) = 19.79, p &lt; 0.001, φ = 0.40, and were marginally more likely to experience clinically significant depression, χ2(1, N = 120) = 3.03, p = 0.08, φ = 0.16, than not sleep disturbed athletes. There were no cognitive differences between the groups, p &gt; 0.05. A greater proportion of sleep disturbed athletes experienced LOC (30%) compared to not sleep disturbed athletes (13%), χ2(1, N = 118) = 4.99, p = 0.03, φ = −0.21.ConclusionSleep disturbances following SRC are associated with a broad range of self-reported symptoms. LOC may be associated with an increased risk of developing sleep disturbances; alternatively, sleep disturbances may increase the risk of LOC following concussion.
Updated review of advances in microRNAs and complex diseases: towards systematic evaluation of computational models
Authors: Huang Li , Zhang Li , Chen Xing 
Published: September 2022

AbstractCurrently, there exist no generally accepted strategies of evaluating computational models for microRNA-disease associations (MDAs). Though K-fold cross validations and case studies seem to be must-have procedures, the value of K, the evaluation metrics, and the choice of query diseases as well as the inclusion of other procedures (such as parameter sensitivity tests, ablation studies and computational cost reports) are all determined on a case-by-case basis and depending on the researchers’ choices. In the current review, we include a comprehensive analysis on how 29 state-of-the-art models for predicting MDAs were evaluated. Based on the analytical results, we recommend a feasible evaluation workflow that would suit any future model to facilitate fair and systematic assessment of predictive performance.
QuickDeconvolution: fast and scalable deconvolution of linked-read sequencing data
Authors: Faure Roland , Lavenier Dominique 
Published: September 2022

Abstract

Motivation
Recently introduced, linked-read technologies, such as the 10× chromium system, use microfluidics to tag multiple short reads from the same long fragment (50–200 kb) with a small sequence, called a barcode. They are inexpensive and easy to prepare, combining the accuracy of short-read sequencing with the long-range information of barcodes. The same barcode can be used for several different fragments, which complicates the analyses.

Results
We present QuickDeconvolution (QD), a new software for deconvolving a set of reads sharing a barcode, i.e. separating the reads from the different fragments. QD only takes sequencing data as input, without the need for a reference genome. We show that QD outperforms existing software in terms of accuracy, speed and scalability, making it capable of deconvolving previously inaccessible data sets. In particular, we demonstrate here the first example in the literature of a successfully deconvoluted animal sequencing dataset, a 33-Gb Drosophila melanogaster dataset. We show that the taxonomic assignment of linked reads can be improved by deconvoluting reads with QD before taxonomic classification.

Availability and implementation
Code and instructions are available on https://github.com/RolandFaure/QuickDeconvolution.

Supplementary information
Supplementary data are available at Bioinformatics Advances online.
Serious Case Reviews and Extra-Familial Harm: Missed and Emerging Opportunities to Develop Contextual Practices
Authors: Firmin Carlene , Manister Molly , Peace Delphine 
Published: September 2022

AbstractThe interpersonal harms that young people experience beyond their families have been documented internationally as have the challenges of protecting those effected using existing child welfare systems. Concern about this in the UK has led to development of ‘contextual’ child protection systems—capable of targeting the peer group, school and community contexts where extra-familial harm (EFH) occurs. This study examined whether reviews of serious incidents (serious case reviews (SCRs)) provide an evidence-base for understanding the contextual dynamics of EFH and/or developing contextual responses. SCRs (n = 49) from 2010–2020, where adolescents were harmed in extra-familial contexts, were analysed over two stages. Stage 1 involved thematic coding under four research questions. Using a framework analysis, Stage 1 themes were grouped around according to: contexts associated with EFH; the nature of social work responses and case review recommendations. Findings suggest that SCRs provide a limited account of the contextual dynamics of EFH. Whilst reviews illustrate that social work responses rarely address the contextual dynamics of EFH, many reviewers have neglected to focus on this shortfall when recommending service improvements. For case reviews to inform contextual child protection systems, information provided to review authors and the design of review requires adaptation.
Remdesivir Resistance in Transplant Recipients With Persistent Coronavirus Disease 2019
Authors: Hogan John I , Duerr Ralf , Dimartino Dacia , Marier Christian , Hochman Sarah E , Mehta Sapna , Wang Guiqing , Heguy Adriana 
Published: September 2022

Abstract
New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications.
365. PROGNOSTIC COMPARISON OF LYMPHOVASCULAR INVASION AND LYMPH NODE METASTASIS IN ESOPHAGEAL CANCER PATIENTS
Authors: Li Kexun , Leng Xue Feng , Nie Xin , Liu Kun , He Wenwu , Wang Qifeng , Luo Xi , Wang Chenghao , Wang Kangning , Liu Guangyuan , Wei Xing , Li Haojun , Zhou Qiang , Li Zhiyu , Jiang Longlin , Zheng Kai , Li Changding , Mao Tianqin , Luo Xi , Fang Qiang , Xiao WenGuang , Han Yongtao , Peng Lin 
Published: September 2022

Abstract
The incidence and mortality of esophageal cancer are high-ranking in the world, more than half of cases occur in China. The cornerstone of treatment for resectable esophageal cancer is esophagectomy. Lymphovascular invasion and lymph node metastasis are both vital prognostic factors for patients who have been through esophagectomy. But in fact, the combined influence of these two factors on prognosis remains controversial.
Samples were obtained from the Sichuan Cancer Hospital & Institute Esophageal Cancer Case Management Database (SCH-ECCM Database). We retrospectively analyzed esophageal cancer patients who underwent esophagectomy from Jan. 2010 to Dec. 2016. Patients were divided into two groups according to the postoperative pathological outcomes: patients with only lymph node metastasis were pointed into group A, patients with only lymphovascular invasion were distributed to group B. Clinical outcomes and survival data were compared using TNM stages of AJCC 8th edition.
After 68.1 months of median follow-up time, 1596 patients who received esophagectomy were included. The median overall survival (OS) was 45.9 months (95% CI 38.5–53.2). Only lymph node metastasis group achieved median OS of 34.9 months (95% CI 30.7–39.1), however, only lymphovascular invasion group did not reach the median OS time. The OS at 1, 3, and 5 years were 91%, 70%, and 64% in the only lymphovascular invasion group group, respectively. In the only lymph node metastasis group, the OS rates at 1, 3, and 5 years were 82%, 49%, and 37%, respectively (HR 0.438, 95% CI 0.3074–0.624, P = 0.0012).
Esophageal cancer patients with only lymph node metastasis had significantly worse OS than the patients with only lymphovascular invasion. It reveals that we should pay more attention to these risk factors, and further studies need to be done to stratify the accurate subgroups.
Evaluation of tumor regression by neoadjuvant chemotherapy regimens for esophageal adenocarcinoma: a systematic review and meta-analysis
Authors: Chidambaram Swathikan , Sounderajah Viknesh , Maynard Nick , Owen Richard , Markar Sheraz R 
Published: September 2022

Abstract
Locally advanced esophageal adenocarcinomas (EACs) are treated with multimodal therapy, namely surgery, neoadjuvant chemotherapy (NAC) or chemoradiotherapy (CRT) depending on patient and tumor level factors. Yet, there is little consensus on choice of the optimum systemic therapy. To compare the pathological complete response (pCR) after FLOT, non-FLOT-based chemotherapy and chemoradiotherapy regimes in patients with EACs. A systematic review of the literature was performed using MEDLINE, EMBASE, the Cochrane Review and Scopus databases. Studies were included if they had investigated the use of chemo(radio)therapy regimens in the neoadjuvant setting for EAC and reported the pCR rates. A meta-analysis of proportions was performed to compare the pooled pCR rates between FLOT, non-FLOT and CRT cohorts. We included 22 studies that described tumor regression post-NAC. Altogether, 1,056 patients had undergone FLOT or DCF regimes, while 1,610 patients had received ECF or ECX. The pCR rates ranged from 3.3% to 54% for FLOT regimes, while pCR ranged between 0% and 31% for ECF/ECX protocols. Pooled random-effects meta-meta-analysis of proportions showed a statistically significant higher incidence of pCR in FLOT-based chemotherapy at 0.148 (95%CI: 0.080, 0.259) compared with non-FLOT-based chemotherapy at 0.074 (95%CI: 0.042, 0.129). However, pCR rates were significantly highest at 0.250 (95%CI: 0.202, 0.306) for CRT. The use of enhanced FLOT-based regimens have improved the pCR rates for chemotherapeutic regimes but still falls short of pathological outcomes from CRT. Further work can characterize clinical responses to neoadjuvant therapy and determine whether an organ-preservation strategy is feasible.
Matching with semi-bandits
Authors: Kasy Maximilian , Teytelboym Alexander 
Published: September 2022

SummaryWe consider an experimental setting in which a matching of resources to participants has to be chosen repeatedly and returns from the individual chosen matches are unknown, but can be learned. Our setting covers two-sided and one-sided matching with (potentially complex) capacity constraints, such as refugee resettlement, social housing allocation, and foster care. We propose a variant of the Thompson sampling algorithm to solve such adaptive combinatorial allocation problems. We give a tight, prior-independent, finite-sample bound on the expected regret for this algorithm. Although the number of allocations grows exponentially in the number of matches, our bound does not. In simulations based on refugee resettlement data using a Bayesian hierarchical model, we find that the algorithm achieves half of the employment gains (relative to the status quo) that could be obtained in an optimal matching based on perfect knowledge of employment probabilities.