bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exposure and work‐related factors in subjects with hand eczema: Data from a cross‐sectional questionnaire within the Lifelines Cohort Study
Authors: Brands Marjolein J. , Loman Laura , Schuttelaar Marie L.A. 
Published: February 2022

AbstractBackgroundHand eczema (HE) is the most frequently occurring occupational skin disease. However, studies on non‐occupational wet exposure, occupations not considered as high‐risk, and socioeconomic factors regarding HE are scarce.ObjectivesTo investigate the association between HE and occupational and non‐occupational wet exposure and work‐related factors in the Dutch general population.MethodsWithin the Lifelines Cohort Study, participants with HE were identified by a digital, add‐on questionnaire that included questions regarding exposure. Data on work‐related and socioeconomic factors were collected from baseline.ResultsOverall, 57 046 participants (42.0%) were included. Occupational and non‐occupational wet exposure were positively associated with HE in the past year (odds ratios (ORs) 1.35, [95% confidence interval (CI): 1.22–1.49] and 1.34, [95%CI: 1.17‐1.53], respectively). Positive associations for high‐risk occupations (OR 1.20, [95%CI: 1.06‐1.36] for personal care workers in health services and OR 1.25, [95%CI: 1.06‐1.48] for nursing and midwifery professionals), occupations not considered as high‐risk (OR 1.19, [95%CI: 1.03‐1.39] for legal, social and religious associate professionals) and higher levels of education were found (OR 1.17, [95%CI: 1.04‐1.32] and OR 1.18, [95%CI: 1.04‐1.34] for middle and high level, respectively).ConclusionPreventive strategies for HE should focus on avoidance of all wet exposure, regardless of origin. In addition, job tasks instead of job title should be taken into account. As previous results on the association between HE and socioeconomic factors differ, future research should focus on a uniform definition of socioeconomic status.
Semantic Attraction in Sentence Comprehension
Authors: Laurinavichyute Anna , von der Malsburg Titus 
Published: February 2022

AbstractAgreement attraction is a cross‐linguistic phenomenon where a verb occasionally agrees not with its subject, as required by grammar, but instead with an unrelated noun (“The key to the cabinets were…”). Despite the clear violation of grammatical rules, comprehenders often rate these sentences as acceptable. Contenders for explaining agreement attraction fall into two broad classes: Morphosyntactic accounts specifically designed to explain agreement attraction, and more general sentence processing models, such as the Lewis and Vasishth model, which explain attraction as a consequence of how linguistic structure is stored and accessed in content‐addressable memory. In the present research, we disambiguate between these two classes by testing a surprising prediction made by the Lewis and Vasishth model but not by the morphosyntactic accounts, namely, that attraction should not be limited to morphosyntax, but that semantic features of unrelated nouns equally induce attraction. A recent study by Cunnings and Sturt provided initial evidence that this may be the case. Here, we report three single‐trial experiments in English that compared semantic and agreement attraction and tested whether and how the two interact. All three experiments showed strong semantically induced attraction effects closely mirroring agreement attraction effects. We complement these results with computational simulations which confirmed that the Lewis and Vasishth model can faithfully reproduce the observed results. In sum, our findings suggest that attraction is a more general phenomenon than is commonly believed, and therefore favor more general sentence processing models, such as the Lewis and Vasishth model.
Understanding “Why:” How Implicit Questions Shape Explanation Preferences
Authors: Joo Sehrang , Yousif Sami R. , Keil Frank C. 
Published: February 2022

AbstractAdults and children ‘promiscuously’ endorse teleological answers to ‘why’ questions—a tendency linked to arguments that humans are intuitively theistic and naturally unscientific. But how do people arrive at an endorsement of a teleological answer? Here, we show that the endorsement of teleological answers need not imply unscientific reasoning (n = 880). A series of experiments show that (a) ‘why’ questions can be understood as a query for one of two distinct kinds of information and (b) these “implicit questions” can explain adults’ answer preferences without appeal to unscientific worldviews. As a strong test of this view, we show that people endorse teleological answers that can answer relevant (implicit) questions about something's purpose, even when those answers are explicitly non‐causal. Thus, we argue that endorsement of teleological answers does not necessarily equate to the endorsement of teleological ‘explanations’: Instead, explanation preferences may simply be an indication of people's pragmatic expectations about the questions that others ask. This view reframes how we should think about explanation preferences in general, while also offering practical insight into the pragmatics of question asking.
Leveraging large observational studies to discover genetic determinants of drug concentrations: A proof‐of‐concept study
Authors: Meloche Maxime , Leclair Grégoire , Jutras Martin , Oussaïd Essaïd , Gaulin Marie‐Josée , Mongrain Ian , Busseuil David , Tardif Jean‐Claude , Dubé Marie‐Pierre , de Denus Simon 
Published: February 2022

AbstractLarge, observational genetic studies are commonly used to identify genetic factors associated with diseases and disease‐related traits. Such cohorts have not been commonly used to identify genetic predictors of drug dosing or concentrations, perhaps because of the heterogeneity in drug dosing and formulation, and the random timing of blood sampling. We hypothesized that large sample sizes relative to traditional pharmacokinetic studies would compensate for this variability and enable the identification of pharmacogenetic predictors of drug concentrations. We performed a cross‐sectional, proof‐of‐concept association study to replicate the well‐established association between metoprolol concentrations and CYP2D6 genotype‐inferred metabolizer phenotypes in participants from the Montreal Heart Institute Hospital Cohort undergoing metoprolol therapy. Plasma concentrations of metoprolol and α‐hydroxymetoprolol (α‐OH‐metoprolol) were measured in samples collected randomly regarding the previous metoprolol dose. A total of 999 individuals were included. The metoprolol daily dose ranged from 6.25 to 400 mg (mean 84.3 ± 57.1 mg). CYP2D6‐inferred phenotype was significantly associated with both metoprolol and α‐OH‐metoprolol in unadjusted and adjusted models (all p < 10−14). Models for metoprolol daily dose showed consistent results. Our study suggests that randomly drawn blood samples from biobanks can serve as a new approach to discover genetic associations related to drug concentrations and dosing, with potentially broader implications for genomewide association studies on the pharmacogenomics of drug metabolism.
Better together? Assessing different remote sensing products for predicting habitat suitability of wetland birds
Authors: Koma Zsófia , Seijmonsbergen Arie C. , Grootes Meiert W. , Nattino Francesco , Groot Jim , Sierdsema Henk , Foppen Ruud P. B. , Kissling W. Daniel 
Published: February 2022

AbstractAimThe increasing availability of remote sensing (RS) products from airborne laser scanning (ALS) surveys, synthetic aperture radar acquisitions and multispectral satellite imagery provides unprecedented opportunities for describing the physical structure and seasonal changes of vegetation. However, the added value of these RS products for predicting species distributions and animal habitats beyond land cover maps remains little explored. Here, we aim to assess how metrics derived from different types of high‐resolution (10 m) RS products predict the habitat suitability of wetland birds.LocationNorth‐eastern part of the Netherlands.MethodsWe built species distribution models (SDMs) with occurrence observations from territory mapping of two selected wetland bird species (great reed warbler and Savi's warbler) and metrics from a Dutch land cover map, country‐wide ALS and Sentinel‐1 and Sentinel‐2 RS products. We then compared model performance, relative variable importance and response curves of the SDMs to assess the contribution and ecological relevance of each RS product and metric.ResultsOur results showed that ALS and Sentinel metrics improve SDMs with only land cover metrics by 11% and 10% of the Area Under Curve (AUC) for the great reed warbler and the Savi's warbler respectively. Assessments of feature importance revealed that all types of RS products contributed substantially to predicting the habitat suitability of these wetland birds, but that the most important variables vary among species.Main conclusionsOur study demonstrates that metrics from different high‐resolution RS products capture complementary ecological information on animal habitats, including aspects such as the proportional cover of habitat types, vegetation density and the horizontal variability of vegetation height. Land cover maps with detailed spatial and thematic information can already achieve high model accuracies, but adding metrics derived from ALS point clouds and Sentinel imagery further improve model accuracy and enhance the understanding of animal–habitat relationships.
Recognition of tRNAIle with a UAU anticodon by isoleucyl‐tRNA synthetase in lactic acid bacteria
Authors: Uesugi Gakuto , Fukuba Yuho , Yamamoto Takayuki , Inaba Nozomi , Furukawa Haruyuki , Yoshizawa Satoko , Tomikawa Chie , Takai Kazuyuki 
Published: February 2022

In almost all eubacteria, the AUA codon is translated by tRNAIle2 bearing lysidine at the wobble position. Lysidine is introduced by tRNAIle lysidine synthetase (TilS) via post‐transcriptional modification of the cytidine of tRNAIle2(CAU). Lactobacillus casei and Lactobacillus plantarum have tilS homologues and tRNAIle2(CAU) genes. In addition, L. casei also has another tRNAIle2 gene with an UAU anticodon. L. plantarum has a tRNAIle(UAU)‐like RNA. Here, we demonstrate that L. casei tRNAIle2(UAU) is charged with isoleucine by L. casei isoleucyl‐tRNA synthetase (IleRS) but not by L. plantarum IleRS, even though the amino acid identity of these two enzymes is over 60%. It has been reported that, in Mycoplasma mobile, which has its tRNAIle2(UAU) but no tilS homologue, an Arg residue at position 865 of the IleRS is required for recognition of the UAU anticodon. This position is occupied by an Arg also in the IleRSs from both of the Lactobacillus species. Thus, other residues in L. casei, IleRS should also contribute to the recognition of tRNAIle2(UAU). We found that a chimeric L. casei IleRS in which the N‐terminal domain was replaced by the corresponding region of L. plantatarum IleRS has very low aminoacylation activity towards both tRNAIle2(UAU) and tRNAIle1(GAU). The A18G mutant had barely detectable aminoacylation activity towards either of the tRNAsIle. However, a double point mutant of A18G and G19N aminoacylated tRNAIle1(GAU), but not tRNAIle2(UAU). Our results suggest that, for L. casei IleRS, Ala18 and Gly19 also play a critical role in recognition of tRNAIle2(UAU).
Adverse childhood experiences and onset of migraine in Canadian adolescents: A cohort study
Authors: Hammond Nicole G. , Colman Ian , Orr Serena L. 
Published: February 2022

AbstractBackgroundAdverse childhood experiences (ACEs) are cross‐sectionally associated with headache, including migraine, in pediatric populations.ObjectiveThe objective of this study was to determine whether ACEs are prospectively associated with incident health‐professional diagnosed migraine and prevalence of non‐migraine frequent headache in adolescence, either directly or indirectly through symptoms of depression and anxiety.MethodsWe used data from the National Longitudinal Survey of Children and Youth, a Canadian cohort study that followed children aged 0/1 at baseline, and the person most knowledgeable about them (PMK) until the child reached adolescence. The PMK reported on 14 ACEs (e.g., parental death) when the child was 4/5 and 6/7 years, and symptoms of depression and anxiety in late childhood (age 8/9 years), using a validated tool. Migraine (primary outcome) was ascertained via PMK report of a health‐professional diagnosis, and non‐migraine frequent headache (>1 time per week) was adolescent self‐report, both measured at age 14/15. We estimated direct and indirect effects (IEs) on the log‐odds scale through symptoms of depression and anxiety (mediator). We adjusted for sex, parental migraine, and economic deprivation. The analytic sample sizes were: n = 2058 (migraine) and n = 1730 (frequent headache).ResultsThere were nunweighted = 71 respondents with migraine (3.4%, 71/2058) and nunweighted = 204 with non‐migraine frequent headache (11.8%, 204/1730). Most respondents experienced no ACEs (weighted percentage = 55.7), followed by 1 ACE (weighted percentage = 34.7) and greater than or equal to two ACEs (weighted percentage = 9.6), respectively. There were direct associations between experiencing one (odds ratio [OR] = 1.71, 95% confidence interval [CI]: 1.01–2.87) and equal to or greater than two (OR = 2.33, 95% CI: 1.13–4.80) ACEs and migraine, but not for non‐migraine frequent headache. There were no indirect relationships through symptoms of depression and anxiety for migraine (1 ACE: OR = 1.06, 95% CI: 0.99–1.13 and ≥2 ACEs: OR = 1.11, 95% CI: 0.98–1.28) or non‐migraine frequent headache (1 ACE: OR = 0.99, 95% CI: 0.95–1.03 and ≥2 ACEs: OR = 0.98, 95% CI: 0.90–1.07).ConclusionsACEs may confer an increased risk of migraine onset in adolescence. The association was not explained by symptoms of depression and anxiety in late childhood.
Are psychological interventions efficacious for adults with migraine? A systematic review and meta‐analysis
Authors: Dudeney Joanne , Sharpe Louise , McDonald Sarah , Menzies Rachel E. , McGuire Brian 
Published: February 2022

AbstractObjectiveTo determine the efficacy of psychological interventions in studies of adults with migraine, in reducing pain, and functional and psychosocial difficulties.BackgroundA recently published Cochrane Review showed no strong evidence for psychological intervention for adults with migraine. However, this review was limited by stringent inclusion criteria, potentially resulting in low power. The current review examines the stability of these findings.MethodsCENTRAL, MEDLINE, Embase, PsycINFO, and CINAHL databases were systematically searched from inception to July 31, 2021. Reviewers independently conducted the search and extraction process. Risk of bias was conducted, and we provide GRADE ratings of our confidence in the evidence. We included 39 randomized controlled trials in the meta‐analyses (n = 3155); 31 included data on migraine only and eight combined data from adults with migraine or tension‐type headache (TTH).ResultsIn contrast to the Cochrane Review, for studies including adults with migraine only, we found psychological interventions had a small to medium beneficial effect on improving migraine frequency, pain intensity, and disability post‐treatment, compared to controls (Cohen’s d range 0.23 to 0.33), and disability at follow‐up (d = 0.44). We found no evidence of a beneficial effect on quality‐of‐life post‐treatment, or mood at post‐treatment or follow‐up. Our sensitivity analyses on studies with mixed headache populations (migraine and combined migraine/TTH) found a similar magnitude of effects for most outcomes (d range 0.25 to 0.36), except for mood, which produced a small to medium beneficial effect (d = 0.32).ConclusionWe found evidence that adults with migraine may benefit from psychological intervention, and psychological treatment may equally benefit adults with a range of headache conditions. However, as with previous reviews, quality of the evidence was low, findings should be cautiously interpreted, and this field would benefit from future high‐quality trials.
Lack of local adaptation of feeding and calling behaviours by Yponomeuta cagnagellus moths in response to artificial light at night
Authors: Cieraad Ellen , van Grunsven Roy H. A. , van der Sman Florine , Zwart Nienke , Musters Kees. J. M. , Strange Emily , van Langevelde Frank , Trimbos Krijn B. 
Published: February 2022

Abstract
Artificial light at night (ALAN) is one of the suggested drivers of the global decline in insects, including moths.
ALAN strongly affects moth physiology and behaviour, but it remains unknown whether ALAN is a selective pressure that drives adaptation and evolution in moths.
We assess whether feeding and calling behaviours of Yponomeuta cagnagellus moths are locally adapted to ALAN. Collected from locations that were either illuminated or dark at night‐time for several decades, moths were exposed to different light intensities in a laboratory experiment.
Male moths, but not female moths, fed less frequently in bright light than in dark or dim conditions. Female calling was less frequent in dimly or brightly lit conditions than in the dark treatment. Individuals from illuminated source populations showed increased feeding behaviour by males and marginally decreased calling behaviour by females.
Our study suggests that ALAN affects the phenotypical calling behaviour by females and feeding behaviour by male moths of Y. cagnagellus but has not resulted in adaptation. Long‐term ALAN conditions also affected feeding and marginally affected calling frequency. Reduced calling in lit conditions, perhaps driven by a reduced need for such behaviour because of an increase in visual cues or through the proximity of individuals in lit conditions, may result in long‐term adaptation.
Studies into more moth species are required to determine the extent to which a lack of adaptation to ALAN may contribute to current global declines in moth populations.
Determinants of selection behavior in online distribution channels for fresh food
Authors: Choi Junhwa , Jang Sungsoon , Choi Jae Young 
Published: February 2022

AbstractThis study examines the core factors that determine consumer choices of distribution channels for fresh food during the COVID‐19 pandemic, focusing on online distribution channels and the substitution patterns between online and offline distribution channels. Using 1436 responses to a survey conducted by Gallup Korea, a specialized survey agency in Korea, we adopted a multivariate probit model for the empirical analysis. The results show that consumers who pursued ease of use or had high awareness of online food delivery tended to choose online distribution channels for fresh food, unlike consumers who were sensitive to high quality or low prices. Consumers with high consumer spending, who are living in Seoul or a metropolitan area, have children of 10 years old or younger, and have a high educational level had positive relationships with the choice of an online distribution channel. Additionally, the estimates of the variance‐covariance matrix showed a complementary relationship between large markets and small and medium‐sized markets, with the possibility of a weak substitution effect between small and medium‐sized markets and online distribution channels.
Rheological and viscoelastic properties of colloidal solutions based on gelatins and chitosan as affected by pH
Authors: Benoso Paula , Bittante Ana Mônica Quinta Barbosa , Moraes Izabel Cristina Freitas , do Amaral Sobral Paulo José 
Published: February 2022

SummaryThe objective of this study was to evaluate the influence of pH on rheological and viscoelastic properties of solutions based on blends of type A (GeA) or type B (GeB) gelatin and chitosan (CH). Solutions of GeA, GeB, CH, GeA:CH, and GeB:CH were prepared in several pH (3.5–6.0) and analyzed for determination of zeta‐potential. Rheological analyses (stationary and dynamic essays) were carried out with blends allowing to study the effect of pH on shear stress, apparent viscosity, loss (G”) and storage (G’) moduli, and angle phase (Tanδ). Zeta potential of all biopolymers decreased linearly as a function of pH. CH presented higher values, and GeB, the lowest one, being the only having negative values at pH > 5. Overall, the pH influenced the rheological and viscoelastic properties of the colloidal solutions: shear stress and apparent viscosity increased as a function of pH. Other assays were carried out at 3% and 5% strain, for GeA:CH and GeB:CH, respectively. In the sol domain, G’ and G” (1 Hz) increased linearly for GeA:CH. But for GeB:CH, they increased in two linear different regions: one function between pH 3.5 and 5.0 and another one between 5.0 and 6.0, being a more important effect was visible in this last domain probably due to the negative net charge of gelatin, above it pI. An effect in two domains was also visible for Tanδ, explained in the same manner as previously. The GeB:CH blends behaved like diluted solutions, and transition temperatures increased as a function of pH.
First accurate profiling of antioxidant anthocyanins and flavonols of Tibouchina urvilleana and Tibouchina mollis edible flowers aided by fractionation with Amberlite XAD‐7
Authors: Solarte Natalia , Cejudo‐Bastante María Jesús , Hurtado Nelson , Heredia Francisco J. 
Published: February 2022

SummaryA purification and fractionation process of the edible flowers of Tibouchina mollis and Tibouchina urvilleana followed by the first attempt to the anthocyanin and flavonol characterisation and identification by UHPLC‐DAD‐ESI‐MS were developed. T. urvilleana exhibited a higher monomeric anthocyanin content, mainly due to the presence of the 3‐O‐(6′‐p‐coumaroyl)‐glucoside derivatives of malvidin and petunidin. Quercetin‐3‐O‐hexoside was the major flavonol identified in T. urvilleana, and the lack of myricetin derivatives was also exhibited. The anthocyanin and flavonol profile of T. mollis was more miscellaneous, characterised by the occurrence of cyanidin‐3‐O‐glucoside followed by the 3‐O‐(6′‐p‐coumaroyl)‐glucoside and 3‐O‐glucoside derivatives of malvidin and petunidin as anthocyanins, and myricetin, quercetin, and 3‐O‐hexosides of kaemperol and quercetin as flavonol compounds. Therefore, the anthocyanin and flavonol profile, through a process based on purification and fractionation, could be a useful tool to ensure the authenticity of the Tibouchina. Furthermore, the purification process made the antioxidant activity increase, which is greatly correlated to the reduction capacity.
Ideas and power in employment relations studies
Authors: Carstensen Martin B. , Ibsen Christian Lyhne , Schmidt Vivien A. 
Published: February 2022

AbstractMotivated by the efforts to understand shifting dynamics of change and stability in employment relations—not least ones brought on by a decade of crisis in what was a neoliberal consensus—scholars increasingly focus on the role of ideas, discourses, and identities. This paper argues for the potential of continuing down this path of employing ideational explanations in employment relations. First, it highlights four key weaknesses of employing more pure materialist–institutionalist approaches that have traditionally dominated employment relations scholarship. Second, it argues that to recognize and build on existing efforts to bring in ideas to employment relations, it is useful to place these on the macro‐, meso‐, and micro levels. Third, to further advance an ideational perspective on employment relations, it proposes to place more centrally the concept of ideational power. Fourth, it presents key insights from the papers that make up the Special Issue and fleshes out how the individual papers of the Special Issue contribute to this agenda.