bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between Synoptic Weather Pattern and Surface Particulate Matter (PM) Concentration During Winter and Spring Seasons Over South Korea
Authors: Lee Dasom , Kim Hyun Cheol , Jeong Jee‐Hoon , Kim Baek‐Min , Lee DaeGyun , Choi Jin‐Young , Song Min Young , Yoon Jin‐Ho 
Published: December 2022

AbstractRegional air quality over East Asia, including South Korea, has recently become a center of public attention because of a few episodes of very high particulate matter (PM) concentrations. Predicting PM variation with lead time of a few hours up to days is one of the key areas that the governments are working on because it can benefit from an early warning system to short‐term mitigation effort. In this study, the influence of synoptic weather conditions on regional air quality was investigated with the occurrence frequencies of PM episodes as a function of various synoptic weather patterns during winter and spring. During winter, dry moderate (DM) types occur frequently alongside high PM cases (24 hr mean PM10 concentration >). The composite weather map showed a weak northwesterly wind field as a potential cause. On the contrary, it is interesting to note that dry polar types can be associated with low PM cases (24 hr mean PM10 concentration <) as well as high PM depending on near‐surface wind speed. Furthermore, DM and dry tropical types were found to be highly correlated with high (higher) PM concentrations during spring season, likely because of the enhanced static stability in the lower troposphere. It should be noted that PM concentration depends on the lower atmospheric stability. The close relationship between synoptic weather patterns and PM concentration suggests that synoptic weather can play an important role in regional air quality.
Thrust Faults Bound an Elevated Mantle Plug Beneath Several Lunar Basins
Authors: Collins Matthew S. , Byrne Paul K. , Klimczak Christian , Mazarico Erwan 
Published: December 2022

AbstractThe lunar maria are large expanses of basalt that infill antecedent impact basins and show evidence for postemplacement deformation. Landforms within many of these basins suggest a period of compressive tectonics, although their formation mechanism has yet to be established. Previous work for Mare Crisium demonstrated that basin‐circumferential wrinkle ridges, which typically demarcate the inner edge of an annulus of elevated terrain, are the result of deep‐seated thrust faults that preferentially form along the boundary of an elevated superisostatic portion of mantle and a thick, subisostatic collar of crustal material. Here, we show that a similar fault architecture exists for several other mascon‐bearing basins, including Maria Serenitatis, Nectaris, Moscoviense, and, to a lesser degree, Humorum and Imbrium. These deeply penetrating basin‐circumferential thrust faults, as for Mare Crisium, form a (partial) outward‐dipping ring‐fault system that bounds the elevated mantle plug beneath each basin as a geometric consequence of mascon evolution. If this geometric arrangement is unique to the Moon, then some characteristic(s) of lunar mascon evolution enables the formation of such mascon‐bounding faults. Despite the ubiquitous nature of mascon‐bound thrust ring faults at several lunar basins, whether such structures exist at mascon basins on other terrestrial worlds remains an open question.
Panel testing for the molecular genetic diagnosis of congenital hypogonadotropic hypogonadism – a clinical perspective
Authors: Al Sayed Yasmin , Howard Sasha R. 
Published: December 2022

AbstractCongenital hypogonadotropic hypogonadism (CHH) is a rare endocrine disorder that results in reproductive hormone deficiency and reduced potential for fertility in adult life. Discoveries of the genetic aetiology of CHH have advanced dramatically in the past 30 years, with currently over 40 genes recognised to cause or contribute to the development of this condition. The genetic complexity of CHH is further increased by the observation of di- and oligogenic, as well as classic monogenic, inheritance and incomplete penetrance. Very recently in the UK, a panel of 14 genes has been curated for the genetic diagnosis of CHH within the NHS Genomic Medicine Service programme. The aim of this review is to appraise the advantages and potential pitfalls of the use of a CHH panel in clinical endocrine diagnostics, and to consider the future avenues for developing this panel including the potential of whole exome or whole genome sequencing data analysis in this condition.
Fidelity bounds for device-independent advantage distillation
Authors: Hahn Thomas A. , Tan Ernest Y.-Z. 
Published: December 2022

AbstractIt is known that advantage distillation (that is, information reconciliation using two-way communication) improves noise tolerances for quantum key distribution (QKD) setups. Two-way communication is hence also of interest in the device-independent case, where noise tolerance bounds for one-way error correction are currently too low to be experimentally feasible. Existing security proofs for the device-independent repetition-code protocol (the most prominent form of advantage distillation) rely on fidelity-related security conditions, but previous bounds on the fidelity were not tight. We improve on those results by developing an algorithm that returns arbitrarily tight lower bounds on the fidelity. Our results give insight on how strong the fidelity-related security conditions are, and could also be used to compute some lower bounds on one-way protocol keyrates. Finally, we conjecture a necessary security condition for the protocol studied in this work, that naturally complements the existing sufficient conditions.
Historical red-lining is associated with fossil fuel power plant siting and present-day inequalities in air pollutant emissions
Authors: Cushing Lara J. , Li Shiwen , Steiger Benjamin B. , Casey Joan A. 
Published: December 2022

AbstractStationary sources of air pollution are disproportionately located in communities of colour, but the causes for this disparity are unclear. Here we assess whether racialized appraisals of investment risk (‘red-lining’) undertaken by the US federal Home Owners’ Loan Corporation in the 1930s influenced the subsequent siting of fossil fuel power plants. Across 8,871 neighbourhoods in 196 US urban areas, we observed a stepwise correlation between risk grade, number of power plants and cumulative quantity of power plant emissions upwind and within 5 km. Controlling for pre-existing power plants, neighbourhoods deemed ‘hazardous’ (D grade, ‘red-lined’) had a higher likelihood of a fossil fuel power plant being sited between 1940 and 1969 (72%), 1970 and 1999 (20%) and 2000 and 2019 (31%), and higher average present-day emissions of nitrous oxides (82%), sulfur dioxide (38%) and fine particulate matter (63%) compared with ‘declining’ (C-graded) neighbourhoods. Our results suggest racism in the housing market contributed to inequalities in present-day power plant emissions burdens.
High-performing organic electronics using terpene green solvents from renewable feedstocks
Authors: Corzo Daniel , Rosas-Villalva Diego , C Amruth , Tostado-Blázquez Guillermo , Alexandre Emily Bezerra , Hernandez Luis Huerta , Han Jianhua , Xu Han , Babics Maxime , De Wolf Stefaan , Baran Derya 
Published: December 2022

AbstractAccelerating the shift towards renewable materials and sustainable processes for printed organic electronic devices is crucial for a green circular economy. Currently, the fabrication of organic devices with competitive performances is linked to toxic petrochemical-based solvents with considerable carbon emissions. Here we show that terpene solvents obtained from renewable feedstocks can replace non-renewable environmentally hazardous solvent counterparts in the production of highly efficient organic photovoltaics (OPVs) light-emitting diodes (OLEDs) and field-effect transistors (OFETs) with on-par performances. Using a Hansen solubility ink formulation framework, we identify various terpene solvent systems and investigate effective film formation and drying mechanisms required for optimal charge transport. This approach is universal for state-of-the-art materials in OPVs, OLEDs and OFETs. We created an interactive library for green solvent selections and made it publicly available through the OMEGALab website. As potential carbon-negative solvents, terpenes open a unique and universal approach towards efficient, large-area and stable organic electronic devices.
Maximum-likelihood model fitting for quantitative analysis of SMLM data
Authors: Wu Yu-Le , Hoess Philipp , Tschanz Aline , Matti Ulf , Mund Markus , Ries Jonas 
Published: December 2022

AbstractQuantitative data analysis is important for any single-molecule localization microscopy (SMLM) workflow to extract biological insights from the coordinates of the single fluorophores. However, current approaches are restricted to simple geometries or require identical structures. Here, we present LocMoFit (Localization Model Fit), an open-source framework to fit an arbitrary model to localization coordinates. It extracts meaningful parameters from individual structures and can select the most suitable model. In addition to analyzing complex, heterogeneous and dynamic structures for in situ structural biology, we demonstrate how LocMoFit can assemble multi-protein distribution maps of six nuclear pore components, calculate single-particle averages without any assumption about geometry or symmetry, and perform a time-resolved reconstruction of the highly dynamic endocytic process from static snapshots. We provide extensive simulation and visualization routines to validate the robustness of LocMoFit and tutorials to enable any user to increase the information content they can extract from their SMLM data.
The psychological and political correlates of conspiracy theory beliefs
Authors: Uscinski Joseph , Enders Adam , Diekman Amanda , Funchion John , Klofstad Casey , Kuebler Sandra , Murthi Manohar , Premaratne Kamal , Seelig Michelle , Verdear Daniel , Wuchty Stefan 
Published: December 2022

AbstractUnderstanding the individual-level characteristics associated with conspiracy theory beliefs is vital to addressing and combatting those beliefs. While researchers have identified numerous psychological and political characteristics associated with conspiracy theory beliefs, the generalizability of those findings is uncertain because they are typically drawn from studies of only a few conspiracy theories. Here, we employ a national survey of 2021 U.S. adults that asks about 15 psychological and political characteristics as well as beliefs in 39 different conspiracy theories. Across 585 relationships examined within both bivariate (correlations) and multivariate (regression) frameworks, we find that psychological traits (e.g., dark triad) and non-partisan/ideological political worldviews (e.g., populism, support for violence) are most strongly related to individual conspiracy theory beliefs, regardless of the belief under consideration, while other previously identified correlates (e.g., partisanship, ideological extremity) are inconsistently related. We also find that the correlates of specific conspiracy theory beliefs mirror those of conspiracy thinking (the predisposition), indicating that this predisposition operates like an ‘average’ of individual conspiracy theory beliefs. Overall, our findings detail the psychological and political traits of the individuals most drawn to conspiracy theories and have important implications for scholars and practitioners seeking to prevent or reduce the impact of conspiracy theories.
Induction of type II collagen expression in M2 macrophages derived from peripheral blood mononuclear cells
Authors: Wang Fu-Hui , Hsieh Chia-Ying , Shen Ching-I. , Chuang Chang-Han , Chung Yu-Hsuan , Kuo Chi-Chung , Lee Kuan-Der , Lin Chih-Lung , Su Hong-Lin 
Published: December 2022

AbstractThe human type II collagen (Col II), specifically expressed in chondrocytes, is a crucial component of the adult hyaline cartilage. We examine the potential of artificial induction of Col II in human peripheral blood mononuclear cells (PBMNCs) as a novel Col II provider. Human PBMNCs were purified and were treated with high doses of macrophage-colony stimulating factor (M-CSF), granulocyte macrophage-colony stimulating factor (GM-CSF), or granulocyte-colony stimulating factor (G-CSF) and examined the Col II expression at indicated days. Quantitative Col II expression was validated by real-time reverse transcriptase-polymerase chain reaction (RT-PCR), immunocytochemistry, and flow cytometry. We demonstrate that monocytes in PBMNCs can be artificially induced to express both Col II proteins and M2 macrophage markers by the high concentration of colony-stimulating factors, especially M-CSF and GM-CSF. The Col II proteins were detected on the cell membrane and in the cytoplasm by flow cytometry and immunocytostaining. Combination with IL-4 provided a synergistic effect with M-CSF/GM-CSF to trigger Col II expression in M2 macrophages. These CD206 and Col II double-expressing cells, named modified macrophages, share M2 macrophages' anti-inflammatory potency. We demonstrated that the modified macrophages could significantly attenuate the inflammatory progress of Complete Freund's adjuvant (CFA)-induced arthritis and collagen-induced arthritis in rodents. Here, we provide the first evidence that a modified macrophage population could ectopically express Col II and control the progress of arthritis in animals.
Frames of reference in small-scale spatial tasks in wild bumblebees
Authors: Martin-Ordas Gema 
Published: December 2022

AbstractSpatial cognitive abilities are fundamental to foraging animal species. In particular, being able to encode the location of an object in relation to another object (i.e., spatial relationships) is critical for successful foraging. Whether egocentric (i.e., viewer-dependent) or allocentric (i.e., dependent on external environment or cues) representations underlie these behaviours is still a highly debated question in vertebrates and invertebrates. Previous research shows that bees encode spatial information largely using egocentric information. However, no research has investigated this question in the context of relational similarity. To test this, a spatial matching task previously used with humans and great apes was adapted for use with wild-caught bumblebees. In a series of experiments, bees first experienced a rewarded object and then had to spontaneously (Experiment 1) find or learn (Experiments 2 and 3) to find a second one, based on the location of first one. The results showed that bumblebees predominantly exhibited an allocentric strategy in the three experiments. These findings suggest that egocentric representations alone might not be evolutionary ancestral and clearly indicate similarities between vertebrates and invertebrates when encoding spatial information.
Beta rhythmicity in human motor cortex reflects neural population coupling that modulates subsequent finger coordination stability
Authors: Iwama Seitaro , Yanagisawa Takufumi , Hirose Ryotaro , Ushiba Junichi 
Published: December 2022

AbstractHuman behavior is not performed completely as desired, but is influenced by the inherent rhythmicity of the brain. Here we show that anti-phase bimanual coordination stability is regulated by the dynamics of pre-movement neural oscillations in bi-hemispheric primary motor cortices (M1) and supplementary motor area (SMA). In experiment 1, pre-movement bi-hemispheric M1 phase synchrony in beta-band (M1-M1 phase synchrony) was online estimated from 129-channel scalp electroencephalograms. Anti-phase bimanual tapping preceded by lower M1-M1 phase synchrony exhibited significantly longer duration than tapping preceded by higher M1-M1 phase synchrony. Further, the inter-individual variability of duration was explained by the interaction of pre-movement activities within the motor network; lower M1-M1 phase synchrony and spectral power at SMA were associated with longer duration. The necessity of cortical interaction for anti-phase maintenance was revealed by sham-controlled repetitive transcranial magnetic stimulation over SMA in another experiment. Our results demonstrate that pre-movement cortical oscillatory coupling within the motor network unknowingly influences bimanual coordination performance in humans after consolidation, suggesting the feasibility of augmenting human motor ability by covertly monitoring preparatory neural dynamics.
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer
Authors: Cappellesso Federica , Orban Marie-Pauline , Shirgaonkar Niranjan , Berardi Emanuele , Serneels Jens , Neveu Marie-Aline , Di Molfetta Daria , Piccapane Francesca , Caroppo Rosa , Debellis Lucantonio , Ostyn Tessa , Joudiou Nicolas , Mignion Lionel , Richiardone Elena , Jordan Bénédicte F. , Gallez Bernard , Corbet Cyril , Roskams Tania , DasGupta Ramanuj , Tejpar Sabine , Di Matteo Mario , Taverna Daniela , Reshkin Stephan J. , Topal Baki , Virga Federico , Mazzone Massimiliano 
Published: December 2022

AbstractSolid tumors are generally characterized by an acidic tumor microenvironment (TME) that favors cancer progression, therapy resistance and immune evasion. By single-cell RNA-sequencing analysis in individuals with pancreatic ductal adenocarcinoma (PDAC), we reveal solute carrier family 4 member 4 (SLC4A4) as the most abundant bicarbonate transporter, predominantly expressed by epithelial ductal cells. Functionally, SLC4A4 inhibition in PDAC cancer cells mitigates the acidosis of the TME due to bicarbonate accumulation in the extracellular space and a decrease in lactate production by cancer cells as the result of reduced glycolysis. In PDAC-bearing mice, genetic or pharmacological SLC4A4 targeting improves T cell-mediated immune response and breaches macrophage-mediated immunosuppression, thus inhibiting tumor growth and metastases. In addition,Slc4a4targeting in combination with immune checkpoint blockade is able to overcome immunotherapy resistance and prolong survival. Overall, our data propose SLC4A4 as a therapeutic target to unleash an antitumor immune response in PDAC.
Chiral phosphoric acid-catalyzed chemo and enantioselective 1,2-addition of isatin-derived β,γ-unsaturated α-ketoesters with 4-aminoindoles at the C7 position
Authors: Zhao Yunlong , Xiao Rou , Fang Weibin , Zhao Junling 
Published: December 2022

The chemo and enantioselective 1,2-addition of isatin-derived β,γ-unsaturated α-ketoesters with indoles at the C7 position was described. Some of the products showed high in vitro cytotoxicity towards several human cancer cell lines.
Opioid-Induced Esophageal Dysmotility (OIED) – A Case Report
Authors: Halasz Victoria , Knittel Leonhard , Fox Mark Robert 
Published: December 2022

AbstractRecent studies have shown that chronic opioid use is associated with an increased risk of symptomatic esophageal motility disorders. Opioid-induced esophageal dysfunction (OIED) is most often identified in patients taking high doses of opioids. This condition is associated with poorer treatment outcomes than primary motility disorders and management of these cases is further complicated by the presence of chronic pain, opioid addiction, and physical and psychological comorbidity.We present the case of a 68-year-old Caucasian woman with OIED, induced by the chronic intake of low-dose Fentanyl and Tramadol prescribed to treat severe back pain. The clinical course highlights the sometimes difficult diagnosis and management of this recently recognized condition.
Repair of an Isolated Traumatic Cranial Luxation of the Radial Head Using a TightRope System in a Cat
Authors: Richard Megane , Vallefuoco Rosario 
Published: December 2022

AbstractA 4.4 kg, a 6-year-old Domestic Shorthair male neutered outdoor cat was diagnosed with an isolated traumatic cranial luxation of the left radial head. Surgical stabilization was achieved using a mini TightRope system (Arthrex Vet Systems, Naples, Florida, United States) to hold the radial head to the ulna without attempting to reconstruct the annular ligament. A range of motion within the normal range was achieved after reduction. At 7-week follow-up after surgery, the cat was walking without lameness; at follow-up by telephone 3 years postoperatively, the owner described the overall quality of life as excellent with good mobility in everyday activities such as jumping, running, and playing. Many publications in veterinary medicine detail congenital radial head luxation, Monteggia lesions, or complete elbow luxation, but traumatic radial head luxation is barely cited as the occurrence is rare. To our knowledge, this is the first reported case of a feline isolated traumatic radial head luxation managed with this technique.
Quantifying Electronic Health Record Data Quality in Telehealth and Office-Based Diabetes Care
Authors: Wiley Kevin K. , Mendonca Eneida , Blackburn Justin , Menachemi Nir , Groot Mary De , Vest Joshua R. 
Published: December 2022

Abstract
Objective Data derived from the electronic health record (EHR) are commonly reused for quality improvement, clinical decision-making, and empirical research despite having data quality challenges. Research highlighting EHR data quality concerns has largely been examined and identified during traditional in-person visits. To understand variations in data quality among patients managing type 2 diabetes mellitus (T2DM) with and without a history of telehealth visits, we examined three EHR data quality dimensions: timeliness, completeness, and information density.
Methods We used EHR data (2016–2021) from a local enterprise data warehouse to quantify timeliness, completeness, and information density for diagnostic and laboratory test data. Means and chi-squared significance tests were computed to compare data quality dimensions between patients with and without a history of telehealth use.
Results Mean timeliness or T2DM measurement age for the study sample was 77.8 days (95% confidence interval [CI], 39.6–116.4). Mean completeness for the sample was 0.891 (95% CI, 0.868–0.914). The mean information density score was 0.787 (95% CI, 0.747–0.827). EHR data for patients managing T2DM with a history of telehealth use were timelier (73.3 vs. 79.8 days), and measurements were more uniform across visits (0.795 vs. 0.784) based on information density scores, compared with patients with no history of telehealth use.
Conclusion Overall, EHR data for patients managing T2DM with a history of telehealth visits were generally timelier and measurements were more uniform across visits than for patients with no history of telehealth visits. Chronic disease care relies on comprehensive patient data collected via hybrid care delivery models and includes important domains for continued data quality assessments prior to secondary reuse purposes.