bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ambulatory total hip arthroplasty: Causes for failure to launch and associated risk factors
Authors: Rodriguez Samuel , Shen Tony S. , Lebrun Drake G. , Della Valle Alejandro G. , Ast Michael P. , Rodriguez Jose A. 
Published: September 2022

Aims The volume of ambulatory total hip arthroplasty (THA) procedures is increasing due to the emphasis on value-based care. The purpose of the study is to identify the causes for failed same-day discharge (SDD) and perioperative factors leading to failed SDD. Methods This retrospective cohort study followed pre-selected patients for SDD THA from 1 August 2018 to 31 December 2020. Inclusion criteria were patients undergoing unilateral THA with appropriate social support, age 18 to 75 years, and BMI < 37 kg/m2. Patients with opioid dependence, coronary artery disease, and valvular heart disease were excluded. Demographics, comorbidities, and perioperative data were collected from the electronic medical records. Possible risk factors for failed SDD were identified using multivariate logistic regression. Results In all, 278 patients were identified with a mean age of 57.1 years (SD 8.1) and a mean BMI of 27.3 kg/m2 (SD 4.5). A total of 96 patients failed SDD, with the most common reasons being failure to clear physical therapy (26%), dizziness (22%), and postoperative nausea and vomiting (11%). Risk factors associated with failed SDD included smokers (odds ratio (OR) 6.24; p = 0.009), a maximum postoperative pain score > 8 (OR 4.76; p = 0.004), and procedures starting after 11 am (OR 2.28; p = 0.015). A higher postoperative tolerable pain goal (numerical rating scale 4 to 10) was found to be associated with successful SDD (OR 2.7; p = 0.001). Age, BMI, surgical approach, American Society of Anesthesiologists grade, and anaesthesia type were not associated with failed SDD. Conclusion SDD is a safe and viable option for pre-selected patients interested in rapid recovery THA. The most common causes for failure to launch were failing to clear physical thereapy and patient symptomatology. Risk factors associated with failed SSD highlight the importance of preoperative counselling regarding smoking cessation and postoperative pain to set reasonable expectations. Future interventions should aim to improve patient postoperative mobilization, pain control, and decrease symptomatology. Cite this article: Bone Jt Open 2022;3(9):684–691.
Light-field micro-endoscopy using a fiber bundle: a snapshot 3D epi-fluorescence endoscope
Authors: Zhou You , Xiong Bo , Song Weizhi , Zhang Xu , Zheng Guoan , Dai Qionghai , Cao Xun 
Published: September 2022

Micro-endoscopes are widely used for detecting and visualizing hard-to-reach areas of the human body and for in vivo observation of animals. A micro-endoscope that can realize 3D imaging at the camera framerate could benefit various clinical and biological applications. In this work, we report the development of a compact light-field micro-endoscope (LFME) that can obtain snapshot 3D fluorescence imaging, by jointly using a single-mode fiber bundle and a small-size light-field configuration. To demonstrate the real imaging performance of our method, we put a resolution chart in different

z

positions and capture the z-stack images successively for reconstruction, achieving 333-μm-diameter field of view, 24 μm optimal depth of field, and up to 3.91 μm spatial resolution near the focal plane. We also test our method on a human skin tissue section and HeLa cells. Our LFME prototype provides epi-fluorescence imaging ability with a relatively small (2-mm-diameter) imaging probe, making it suitable for in vivo detection of brain activity and gastrointestinal diseases of animals.
Factors associated with symptoms of major depression disorder among transgender women in Northeast Brazil
Authors: Almeida Marcelo Machado de , Silva Luís Augusto Vasconcelos da , Bastos Francisco Inácio , Guimarães Mark Drew Crosland , Coutinho Carolina , de Brito Ana Maria , Cavalcante Socorro , Dourado Inês 
Published: September 2022

Introduction
Transgender women (TGW) are one of the most vulnerable groups, including higher prevalence of HIV and mental health disorders, such as anxiety and depression than in the general population. Major Depression Disorder (MDD) is one of the most important mental health conditions due to an increasing trend in prevalence in the general population. This study aims at describing the prevalence of symptoms of MDD (SMDD) and associated factors among TGW in capitals of three States in Northeast Brazil.

Methods
TGW n = (864) were selected from the cities of Salvador (n = 166), Recife (n = 350), and Fortaleza (n = 348) using Respondent Driven Sampling methodology. Symptoms of MDD were defined according to the Patient Health Questionnaire-9 scale. Multinomial logistic regression was used to compare those with mild/moderate or moderately severe/severe symptoms of depression with those with no depression, respectively, using complex sample design. Weighted Odds Ratio with 95% confidence interval were estimated.

Results
51.1% of the sample was classified as mild/moderate and 18.9% as moderately severe/severe SMDD. Mild/moderate SMDD was associated with a history of sexual violence (OR = 2.06, 95%CI: 1.15–3.68), history of physical violence (OR = 2.09, 95%CI: 1.20–3.67),) and poor self-rated quality of life (OR = 2.14, 95%CI: 1.31–3.49).). Moderately severe/severe SMDD was associated with history of sexual violence (OR = 3.02, 95%CI: 1.17–7.77), history of physical violence (OR = 4.34, 95% CI:1.88–6.96), poor self-rated quality of life (OR = 3.32, 95%CI:1.804–6.12), lack of current social support (OR = 2.53, 95%IC: 1.31–4.88) and lack of family support in childhood (OR = 2.17, 95%IC 1.16–4.05)).

Conclusions
Our findings strengthens the evidence of a higher prevalence of SMDD among TGW as compared to the general population. Public health policies and actions that target social determinants of risk and protection for MDD among TGW must be urgently implemented.
Strengthening Kangaroo Mother Care at a tertiary level hospital in Zambia: A prospective descriptive study
Authors: Muttau Nobutu , Mwendafilumba Martha , Lewis Branishka , Kasprzyk Keilya , Travers Colm , Menon J. Anitha , Mutesu-Kapembwa Kunda , Mangangu Aaron , Kapesa Herbert , Manasyan Albert 
Published: September 2022

Background
Globally, complications due to preterm birth are the leading contributor to neonatal mortality, resulting in an estimated one million deaths annually. Kangaroo Mother Care (KMC) has been endorsed by the World Health Organisation as a low cost, safe, and effective intervention in reducing morbidity and mortality among preterm infants. The objective of this study was to describe the implementation of a KMC model among preterm infants and its impact on neonatal outcomes at a tertiary level hospital in Lusaka, Zambia.

Methods
We conducted a prospective descriptive study using data collected from the KMC room at the University Teaching Hospital between January 2016 and September 2017. Mothers and government nurses were trained in KMC. We monitored skin-to-skin and breastfeeding practices, weight at admission, discharge, and length of admission.

Results
We enrolled 573 neonates into the study. Thirteen extremely low weight infants admitted to the KMC room had graduated to Group A (1,000g-1,499g) at discharge, with a median weight gain of 500g. Of the 419 very low weight neonates at admission, 290 remained in Group A while 129 improved to Group B (1,500g-2,499g), with a median weight gain of 280g. Among the 89 low weight neonates, 1 regressed to Group A, 77 remained in Group B, and 11 improved to Group C (≥2,500g), individually gaining a median of 100g. Of the seven normal weight neonates, 6 remained in Group C individually gaining a median of 100g, and 1 regressed to Group B. Among all infants enrolled, two (0.35%) died in the KMC room.

Conclusions
Based on the RE-AIM metrics, our results show that KMC is a feasible intervention that can improve neonatal outcomes among preterm infants in Zambia. The study findings show a promising, practical approach to scaling up KMC in Zambia.

Trial registration
The trial is registered under ClinicalTrials.gov under the following ID number: NCT03923023.
Psychometric properties of the English version of the Audio Processor Satisfaction Questionnaire (APSQ)
Authors: Felder Jenna , Amann Edda , Anderson Ilona , Stohl Joshua , Billinger-Finke Mareike 
Published: September 2022

Objective
The Audio Processor Satisfaction Questionnaire (APSQ) is a standardized tool to measure a user’s satisfaction with their audio processor(s). It was first developed and validated in the German language. The purpose of the current study was to validate the English version of the APSQ.

Design
The 15 items of the APSQ were translated into English. Item and scale analyses assessed the quality of individual items and of the questionnaire in its entirety.

Study sample
Sixty-seven adults with hearing implants participated. Forty-six of them completed the questionnaire twice within 2–4 weeks.

Results
High mean values were obtained with total scores and with scores of the comfort, social life, and usability domains, indicating that users are generally satisfied with their audio processors. The questionnaire achieved good test-retest reliability with high internal consistency. A significant positive correlation between time since implantation and user satisfaction was found.

Conclusion
Results of the item and reliability analyses suggest that the English version of the APSQ is a valid and reliable tool to assess user satisfaction with their audio processor(s).
It’s made a really hard situation even more difficult: The impact of COVID-19 on families of children with chronic illness
Authors: McLoone Jordana , Wakefield Claire E. , Marshall Glenn M. , Pierce Kristine , Jaffe Adam , Bye Ann , Kennedy Sean E. , Drew Donna , Lingam Raghu 
Published: September 2022

Objective
For over two years, the global COVID-19 pandemic has forced major transformations on health, social, and educational systems, with concomitant impacts on mental health. This study aimed to understand the unique and additional challenges faced by children with chronic illness and their families during the COVID-19 era.

Method
Parents of children receiving treatment for a chronic illness within the neurology, cancer, renal and respiratory clinics of Sydney Children’s Hospital were invited to participate. We used qualitative methodology, including a semi-structured interview guide, verbatim transcription, and thematic analysis supported by QSR NVivo.

Results
Thirteen parents of children receiving tertiary-level care, for nine chronic illnesses, participated. Parents reported intense fears relating to their ill child’s additional vulnerabilities, which included their risk of developing severe COVID-19 disease and the potential impact of COVID-19-related disruptions to accessing clinical care, medications, allied health support and daily care protocols should their parent contract COVID-19. Parents perceived telehealth as a highly convenient and preferred method for ongoing management of less complex healthcare needs. Parents reported that the accrual of additional stressors and responsibilities during the pandemic, experienced in combination with restricted social interaction and reduced access to usual support networks was detrimental to their own mental health. Hospital-based visitation restrictions reduced emotional support, coping, and resilience for both parents and children and in some cases led to marital discord, sibling distress, and financial loss. Supportive factors included increased time spent together at home during the pandemic and improved hygiene practices at school, which dramatically reduced the incidence of non-COVID-19-related communicable illnesses in chronically ill children.

Discussion
For families caring for a chronically ill child, COVID-19 made a difficult situation harder. The pandemic has highlighted the need for targeted psychosocial intervention for vulnerable families, to mitigate current mental health burden and prevent chronic psychological distress.
Survival and lung function decline in patients with definite, probable and possible idiopathic pulmonary fibrosis treated with pirfenidone
Authors: Májek Ondřej , Gregor Jakub , Mogulkoć Nesrin , Lewandowska Katarzyna , Šterclová Martina , Müller Veronika , Hájková Marta , Kramer Mordechai R. , Tekavec-Trkanjec Jasna , Jovanović Dragana , Studnicka Michael , Stoeva Natalia , Kirchgässler Klaus-Uwe , Littnerová Simona , Dušek Ladislav , Vašáková Martina Koziar 
Published: September 2022

Background
There is no clear evidence whether pirfenidone has a benefit in patients with probable or possible UIP, i.e. when idiopathic pulmonary fibrosis (IPF) is diagnosed with a lower degree of diagnostic certainty. We report on outcomes of treatment with pirfenidone in IPF patients diagnosed with various degrees of certainty.

Methods and findings
We followed patients in the multi-national European MultiPartner IPF Registry (EMPIRE) first seen between 2015 and 2018. Patients were assessed with HRCT, histopathology and received a multi-disciplinary team (MDT) IPF diagnosis. Endpoints of interest were overall survival (OS), progression-free survival (PFS) and lung function decline.

Results
A total of 1626 patients were analysed, treated with either pirfenidone (N = 808) or receiving no antifibrotic treatment (N = 818). When patients treated with pirfenidone were compared to patients not receiving antifibrotic treatment, OS (one-, two- and three-year probability of survival 0.871 vs 0.798; 0.728 vs 0.632; 0.579 vs 0.556, P = 0.002), and PFS (one-, two- and three-year probability of survival 0.597 vs 0.536; 0.309 vs 0.281; 0.158 vs 0.148, P = 0.043) was higher, and FVC decline smaller (-0.073 l/yr vs -0.169 l/yr, P = 0.017). The benefit of pirfenidone on OS and PFS was also seen in patients with probable or possible IPF.

Conclusions
This EMPIRE analysis confirms the favourable outcomes observed for pirfenidone treatment in patients with definitive IPF and indicates benefits also for patients with probable or possible IPF.
Orthostatic stress response in pediatric Fontan patients and the effect of ACE inhibition
Authors: Harteveld Lisette M. , Blom Nico A. , van Dijk J. Gert , Reijntjes Robert H. , van Someren Paul J. , Kerkhof Fabian I. , Kuipers Irene M. , Rammeloo Lukas A. J. , de Geus Eco J. C. , ten Harkel Arend D. J. 
Published: September 2022

Background
Many cardiocirculatory mechanisms are involved in the adaptation to orthostatic stress. While these mechanisms may be impaired in Fontan patients. However, it is yet unclear how Fontan patients, who exhibit a critical fluid balance, respond to orthostatic stress. Angiotensin converting enzyme inhibitors are often prescribed to Fontan patients, but they may negatively influence orthostatic tolerance. Therefore, we evaluated the response to orthostatic stress in pediatric Fontan patients before and after treatment with enalapril.

Methods
Thirty-five Fontan patients (aged 14 years) with moderate-good systolic ventricular function without pre-existent enalapril treatment were included. Before and after a three-month enalapril treatment period, the hemodynamic response to head-up tilt test was evaluated by various parameters including cardiac index, blood pressure, cerebral blood flow, aortic stiffness and cardiac autonomous nervous activity. Thirty-four healthy subjects (aged 13 years) served as controls.

Results
Fontan patients had a decreased cerebral blood flow and increased aortic stiffness in the supine position compared to controls, while all other factors did not differ. Patients and controls showed a comparable response to head-up tilt test for most parameters. Twenty-seven patients completed the enalapril study with a mean dosage of 0.3±0.1mg/kg/day. Most parameters were unaffected by enalapril, only the percent decrease in cardiac index to tilt was higher after treatment, but the cardiac index during tilt was not lower (3.0L/min/m2 pre-enalapril versus 2.8L/min/m2 after treatment; P = 0.15).

Conclusion
Pediatric Fontan patients adequately respond to orthostasis with maintenance of blood pressure and cerebral blood flow and sufficient autonomic response. Enalapril treatment did not alter the response.

Clinical trial information
Scientific title: ACE inhibition in Fontan patients: its effect on body fluid regulation (sAFE-study).
The Netherlands National Trial Register: Trail NL6415. Registered 2017-07-20.
Trial information: https://www.trialregister.nl/trial/6415
Dermatofibrosarcoma Protuberans - Case Report and Review of Literature
Authors: Namdev Seth  , Dushyant Varshney  
Published: September 2022

Dermatofibrosarcoma protuberans (DFSP) is an uncommon, slow-growing, locally aggressive soft tissue sarcoma of the skin. The most common age of presentation for this entity of dermis is the third to fifth decade of life, whereas the most common site of involvement is the trunk and lower extremities, accounting for a total of 70 to 90 percent of the cases. Head and neck regions account for 10 to 15 percent of cases with the involvement of the scalp being the most common presentation in this region of the body.[1]
Although DFSP frequently shows local recurrence with the incidence of 20-50 percent of the cases, distant metastasis has been reported rarely.[2] So the cure rate in early diagnosed cases is high with a 10-year survival rate of 99.1 %, so prompt diagnosis of the entity is important along with awareness about the disease.[3] Here in this article, we are going to present a case of DFSP along with a review of the literature regarding the imaging characteristics of the disease.
Propofol ameliorates ischemic brain injury by blocking TLR4 pathway in mice
Authors: Mitsui Kazuha , Kotoda Masakazu , Hishiyama Sohei , Takamino Ayasa , Morikawa Sho , Ishiyama Tadahiko , Matsukawa Takashi 
Published: September 2022

Abstract
Ischemic brain injury is one of the most serious perioperative complications. However, effective preventative methods have not yet been established. This study aimed to investigate whether propofol has neuroprotective effects against ischemic brain injury, with a specific focus on Toll-like receptor 4 (TLR4). Focal brain ischemia was induced via a combination of left common carotid artery occlusion and distal left middle cerebral artery coagulation in mice. Either propofol (10 mg/kg) or vehicle was intravenously injected 10 min prior to the induction of brain ischemia in wild-type and TLR4 knockout mice. Infarct volume, pro-inflammatory cytokine expression, inflammatory cell infiltration, and neurobehavioral function were assessed. Propofol administration significantly reduced infarct volume in wild-type mice (26.9 ± 2.7 vs 15.7 ± 2.0 mm3 at day 7), but not in TLR4 knockout mice. Compared with the control mice, the propofol-treated wild-type mice exhibited lower levels of IL-6 (0.57 ± 0.23 vs 1.00 ± 0.39 at 24 h), and smaller numbers of TLR4-expressing microglia in the penumbra (11.7 ± 3.1 vs 25.1 ± 4.7 cells/0.1 mm2). In conclusion, propofol administration prior to ischemic brain insult attenuated brain injury by blocking the TLR4-dependent pathway and suppressing pro-inflammatory cytokine production.
A INFLUÊNCIA DO CAPITAL HUMANO NA QUALIDADE DE SERVIÇOS
Authors: Perez Vieira Ronaldo , Nakayama Miura Marcio , Flávio Lobo de Castro Júnior Deosir 
Published: September 2022

Este estudo investigou a influência do capital humano na qualidade de serviços no setor bancário de atendimento às micro e pequenas empresas paranaenses. A pesquisa foi realizada com os funcionários de instituições financeiras que atendem micro e pequenas empresas de diversos setores econômicos no estado do Paraná. Foi utilizada a replicação do instrumento de coleta do questionário aplicado no país Europeu de Andorra, dos autores Mariño-Mesías, Rodríguez-Antón & Rubio-Andrada (2015). A avaliação quantitativa utilizada na estatística descritiva foi realizada por meio da utilização do software IBM SPSS Statistics versão 22 e para o Modelo de Equações Estruturais foi utilizado o Software SmartPLS 3. Os resultados apresentados demonstraram alto nível de significância e forte relação quanto ao grau de influência do capital humano na qualidade de serviços.
Jag2b‐Notch3/1b‐mediated neuron‐to‐glia crosstalk controls retinal gliogenesis
Authors: Jin Mengmeng , Zhang Hui , Xu Baijie , Li Yanan , Qin Huiwen , Yu Shuguang , He Jie 
Published: September 2022

AbstractIn the developing central nervous systems (CNS), neural progenitor cells generate neurons and glia in sequential order. However, the influence of neurons on glia generation remains elusive. Here, we report that photoreceptor cell‐derived Jag2b is required for Notch‐dependent Müller glia (MG) generation in the developing zebrafish retina. In jab2b−/− mutants, differentiating MGs are re‐specified into lineage‐related bipolar neuron fate at the expense of mature MG. Single‐cell transcriptome analysis and knock‐in animals reveal that jab2b is specifically expressed in crx+‐photoreceptor cells during MG generation. Crx promoter‐driven jag2b, but not other Notch ligands, is sufficient to rescue the loss of MGs observed in jag2b−/− mutants. Furthermore, we observe a severe and moderate decrease in the number of MGs in notch3−/− and notch1b−/− mutants, respectively, and the activation of Notch3 or Notch1b rescues the MG loss in jag2b−/− mutants. Together, our findings reveal that the interaction of Jag2b and Notch3/Notch1b mediates the crosstalk between neurons and glial cells to ensure the irreversible differentiation of MG, providing novel mechanistic insights into the temporal specification of glial cell fate in a developing vertebrate CNS structure.
Why is There Zero Women Candidate for Governor Election in West Java, Indonesia?
Authors: Malihah Elly , Nurbayani Siti , Anggraeni Leni 
Published: September 2022

Democracy requires active public political participation. Sustainability of general elections is vitally important in democracy. As a developing country, Indonesia is still struggling to implement its democracy. Interesting phenomena in Indonesian democracy, the number of women who run their candidacy in an election is still limited. For instance, in West Java Province Regional Election, there are no women candidates for governor or vice governor. The political sociology perspective sees these phenomena as the patriarchal culture that the community prefers male leader to women. This research aimsÂ atÂ understandingÂ causesÂ of why there are noÂ femaleÂ candidatesÂ in the general election in West Java. This researchÂ makes use ofÂ quantitative approach with survey method aimed to explain political viewsÂ of West Java society about female candidatesÂ in a gubernatorial election. The area of the researchÂ coversÂ West Java province, involving 500 respondents. The data was collected by using the questionnaire distributed by Google Form to people living in this area. The data wereÂ thenÂ analyzed by inferential statistics. This studyÂ indicatesÂ that West JavaÂ residentsÂ stillÂ holdÂ strong ideology on gender differences, believing that a good leader should be male. Even in the smallest scope of institution,Â menÂ is suppossedÂ be a leader. In addition, there is a dichotomy between the public and the personal space for male and female duty. Women are suggested to stay at the private space, while male has a duty at the public sphere. It is alsoÂ evidencedÂ in the research that women voters have little tendency to elect the female candidates. ThisÂ occursÂ not just because of their patriarchal cultural background, but alsoÂ due toÂ their education. ItÂ isÂ indicated that evenÂ femaleÂ voters had higher education, their tendency to elect the women candidate was still low. Â