bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computer-aided molecular modeling and structural analysis of the human centromere protein–HIKM complex
Authors: Uzoeto Henrietta Onyinye , Cosmas Samuel , Ajima Judith Nnedimkpa , Arazu Amarachukwu Vivian , Didiugwu Chizoba Maryann , Ekpo Daniel Emmanuel , Ibiang Glory Omini , Durojaye Olanrewaju Ayodeji 
Published: August 2022

Abstract
Background
Protein–peptide and protein–protein interactions play an essential role in different functional and structural cellular organizational aspects. While Cryo-EM and X-ray crystallography generate the most complete structural characterization, most biological interactions exist in biomolecular complexes that are neither compliant nor responsive to direct experimental analysis. The development of computational docking approaches is therefore necessary. This starts from component protein structures to the prediction of their complexes, preferentially with precision close to complex structures generated by X-ray crystallography.

Results
To guarantee faithful chromosomal segregation, there must be a proper assembling of the kinetochore (a protein complex with multiple subunits) at the centromere during the process of cell division. As an important member of the inner kinetochore, defects in any of the subunits making up the CENP-HIKM complex lead to kinetochore dysfunction and an eventual chromosomal mis-segregation and cell death. Previous studies in an attempt to understand the assembly and mechanism devised by the CENP-HIKM in promoting the functionality of the kinetochore have reconstituted the protein complex from different organisms including fungi and yeast. Here, we present a detailed computational model of the physical interactions that exist between each component of the human CENP-HIKM, while validating each modeled structure using orthologs with existing crystal structures from the protein data bank.

Conclusions
Results from this study substantiate the existing hypothesis that the human CENP-HIK complex shares a similar architecture with its fungal and yeast orthologs, and likewise validate the binding mode of CENP-M to the C-terminus of the human CENP-I based on existing experimental reports.

Graphical abstract
RETRACTED ARTICLE: Ameliorative effects of Artemisia and Echinacea extracts against hepato and cardiotoxicity induced by DMBA on albino rats: experimental and molecular docking analyses
Authors: salah Ebtihal , El esh Heba , Abdel-Reheim Eman S. , Abdul-Hamid Manal 
Published: August 2022

Abstract
Background
Herbal therapy for healing disease has many advantages than drugs. This study investigates the protective efficacy of Artemisia annua (Art) and Echinacea pupurea (Ech) extracts against 7, 12-dimethylbenz (α) anthracene (DMBA) toxicity.

Results
DMBA-treated rats showed a significant increase in the level of serum ALT, AST, LDH and CKMB, also reduction in body weight gain (BWG) ℅, HB, WBCs, RBCs and platelet counts, in addition to histopathological and ultrastructural alterations. Rats treated with Art or Ech after DMBA showed little improvements in the biochemical, hematological, histopathological, ultrastructural and molecular docking results than before DMBA.

Conclusions
This study suggested the ameliorative effect of Ech and Art due to their antioxidant properties, but Ech and Art were more effective if they are given before than after DMBA administration and the marked effect against DMBA toxicity with Ech before DMBA exposure. Also, the molecular docking, molecular properties descriptors, and pharmacoinformatic studies of constituents of extract from Artemisia annua L. and Echinacea purpurea L. exhibited that all studied compounds have better ADMET and physicochemical properties, especially compounds extract from Echinacea purpurea L.

Graphical Abstract
Conditional simulation of non-stationary spatially variable ground motions for long-span bridges across non-uniform site conditions
Authors: Lu Jubin , Hu Liang , Xia Zili , Zhu Songye 
Published: August 2022

AbstractNon-stationary spatially variable ground motions (SVGMs) are commonly modelled as multivariate oscillatory processes based on evolutionary power spectral density (EPSD) functions. The existing conditional simulation algorithms require the known EPSD functions. The EPSD functions are usually assumed to be identical for all locations, which is unreasonable for long-span bridges because variable soil conditions are practically observed at different bridge piers. This paper proposes a conditional simulation algorithm for non-stationary SVGMs in consideration of non-uniform site conditions. The spatial interpolation tool, termed inverse-distance-weighted (IDW) interpolation, is introduced to estimate the EPSD functions at sites without ground motion measurement. Subsequently, the covariance matrix of the random Fourier coefficients of the multivariate oscillatory processes can be calculated. The Kriging estimation is adopted to obtain the unknown random Fourier coefficients, from which the time histories of the non-stationary SVGMs can be conditionally simulated. The proposed conditional simulation algorithm is first validated through a numerical example, in which the EPSD functions of non-uniform sites are represented by a non-stationary Kanai-Tajimi spectrum with different soil parameters. Then, the algorithm is applied to the Jiuzhou Channel Bridge, a navigation channel bridge of the Hong Kong-Zhuhai-Macau Bridge (HZMB), with complex soil and water conditions. Based on the limited in-situ seismic measurement data, the site characteristics in the bridge area are analysed, and the ground motion time histories at all piers can be generated.
Numerical calculation of temperature, velocity, and species concentration distributions in a hot filament chemical vapor deposition in a reactor using a CH4/H2 mixture
Authors: Khelef Nour , Khelfaoui Fethi , Babahani Oumelkheir 
Published: August 2022

AbstractThis study is a numerical modeling of transport phenomena occurring in the reaction chamber during diamond or amorphous hydrogenated carbon films growth by a hot filament chemical vapor deposition (HFCVD) technique. A two-dimensional model was adopted to study the HFCVD reactor. The equations of heat, momentum, and mass transfer were solved numerically; the simulation was performed using a program in FORTRAN language. All temperature, velocity, and species concentration distributions were similar at the filaments and they were also similar between the filaments. The results show that the gas temperature increases when the number of filaments increases from three to four filaments. We also noted an increase in the production of CH3 and C2H5 radicals near the surface; there was also an increase in the growth rate of the thin film. The concentrations of C2H6, C2H4, and C2H5 were very high. Temperature and concentrations were affected by the distance between filaments and the distance filaments-substrates.
Objective Impact of Hematology-Oncology Hospitalist Care in an Inpatient Setting
Authors: Fanucci Kristina A. , Yang Andrew , Chambers Alison , Dizon Don , Safran Howard , Niroula Rabin 
Published: August 2022

PURPOSE: The utilization of the hospitalist care model has increased over the past decade because of improved cost-effectiveness, quality of care, and value that it provides. Studies have shown that compared with the traditional care model, use of hospitalists provides cost-saving and improved value to hospital systems. However, the data for the use of oncology hospitalists (ONC Hosp) are sparse. In this study, we investigate the impact of inpatient ONC Hosp on 30-day readmissions, length of stay (LOS), discharge to hospice, and inpatient mortality when compared with a traditional model where outpatient oncologists manage the acute issues of hospitalized patients with cancer. METHODS: Rhode Island Hospital hired ONC Hosps to attend on the inpatient oncology service. To determine the impact of this new patient care model, we performed a retrospective review of oncology patients admitted to Rhode Island Hospital between July 1, 2012, and June 30, 2018, and compared quality outcomes of 30-day readmission, LOS, discharge to hospice, and inpatient mortality to those from the traditional care model. RESULTS: Compared with outpatient oncologists care, care by ONC Hosp was associated with a significant decrease in 30-day readmissions (23.0% v 29.6%, P = .019) and a significant increase in discharge to hospice (18.1% v 12.1%, P < .001). No significant difference was detected between LOS ( P = .833) or inpatient mortality ( P = .332). CONCLUSION: This study shows that compared with the traditional care model, the use of ONC Hosps has a positive impact on patient care and the potential to add value to the hospital system.
Characterization of 2 Different Prothrombin Complex Concentrates by Different Hemostatic Assays in an In Vitro Hemodilution Model
Authors: Infanger Lukas , Hirschmann Jörg , Schaden Eva , Ulbing Stefan , Pesce Marco-Valerio , Scharner Vincenz , Gratz Johannes 
Published: August 2022

BACKGROUND:
Viscoelastically guided coagulation factor concentrate-based algorithms for the treatment of trauma-induced coagulopathy include the administration of prothrombin complex concentrates (PCCs). However, the exact role of PCC preparations in this context is a matter of debate. Particularly, the ideal diagnostic trigger for their administration and potential differences between heparin-containing and heparin-free preparations remain unclear. We investigated the hypothesis that 2 different PCCs might have distinct influences on in vitro blood coagulation.

METHODS:
We conducted a direct comparison of 2 commercially available PCC preparations (the heparin-containing Beriplex P/N and the heparin-free Cofact) in an in vitro hemodilution model. Sole fibrinogen substitution served as the control group. To characterize the hemostatic changes, we utilized conventional coagulation tests, a thrombin generation assay (TGA), and 2 different viscoelastic hemostatic assays (VHAs; ROTEM delta and ClotPro).

RESULTS:
Irrespective of the diagnostic assay used, no significant differences between the 2 PCC groups were observed. Fibrinogen levels remained stable from the baseline throughout every dilution level. The control group already showed an increased endogenous thrombin potential (ETP; nM·L−1·min−
1) at all dilution levels compared to baseline (baseline, 2829.4 (432.8); 40% dilution, 4211.7 (391.6); 60% dilution, 4290.9 (300.8); 80% dilution, 3861.4 (303.5); all P < .001). Spiking with both PCC preparations led to a further-pronounced thrombin elevation in comparison to the control group (ETP at 40% dilution, PCC1: 4913.3 [370.2], PCC2: 4988.1 [265.7]; 60% dilution, PCC1: 5174.5 [234.7], PCC2: 5390.4 [334.9]; 80% dilution, PCC1: 5253.8 [357.9], PCC2: 5392.6 [313.4]; all P < .001). Conventional coagulation tests did not mirror the TGA results. Despite increased thrombin generation, prothrombin time was significantly prolonged at all dilution levels for the control group, and both PCC groups exhibited significant prolongations at the 60% and 80% dilution levels (all P < .001) compared to baseline. Similarly, VHA did not depict the thrombin elevation. Furthermore, descriptive analyses revealed relevant differences between the 2 VHA devices, particularly at baseline.

CONCLUSIONS:
Both PCC preparations (ie, irrespective of heparin content) induced significant elevation of thrombin generation, which was not depicted by conventional coagulation tests or VHA. Our in vitro results suggest that diagnostic assays routinely used to guide PCC administration might not adequately reflect thrombin generation in bleeding patients.
Evaluation of Open Access Websites for Anesthesia Education
Authors: Evans Faye M. , Krotinger Anna A. , Lilaonitkul Maytinee , Khaled Hiba F. , Pereira Gretchen A. , Staffa Steven J. , Wolbrink Traci A. 
Published: August 2022

BACKGROUND:
While the prevalence of free, open access medical education resources for health professionals has expanded over the past 10 years, many educational resources for health care professionals are not publicly available or require fees for access. This lack of open access creates global inequities in the availability and sharing of information and may have the most significant impact on health care providers with the greatest need. The extent of open access online educational websites aimed for clinicians and trainees in anesthesiology worldwide is unknown. In this study, we aimed to identify and evaluate the quality of websites designed to provide open access educational resources for anesthesia trainees and clinicians.

METHODS:
A PubMed search of articles published between 2009 and 2020, and a Startpage search engine web search was conducted in May 2021 to identify websites using the following inclusion criteria: (1) contain educational content relevant for anesthesia providers or trainees, (2) offer content free of charge, and (3) are written in the English language. Websites were each scored by 2 independent reviewers using a website quality evaluation tool with previous validity evidence that was modified for anesthesia (the Anesthesia Medical Education Website Quality Evaluation Tool).

RESULTS:
Seventy-five articles and 175 websites were identified; 37 websites met inclusion criteria. The most common types of educational content contained in the websites included videos (66%, 25/37), text-based resources (51%, 19/37), podcasts (35%, 13/37), and interactive learning resources (32%, 12/37). Few websites described an editorial review process (24%, 9/37) or included opportunities for active engagement or interaction by learners (30%,11/37). Scores by tertile differed significantly across multiple domains, including disclosure of author/webmaster/website institution; description of an editorial review process; relevancy to residents, fellows, and faculty; comprehensiveness; accuracy; disclosure of content creation or revision; ease of access to information; interactivity; clear and professional presentation of information; and links to external information.

CONCLUSIONS:
We found 37 open access websites for anesthesia education available on the Internet. Many of these websites may serve as a valuable resource for anesthesia clinicians looking for self-directed learning resources and for educators seeking to curate resources into thoughtfully integrated learning experiences. Ongoing efforts are needed to expand the number and improve the existing open access websites, especially with interactivity, to support the education and training of anesthesia providers in even the most resource-limited areas of the world. Our findings may provide recommendations for those educators and organizations seeking to fill this needed gap to create new high-quality educational websites.
On Perspective and Value: Black Urbanism, Black Interiors, and Public Housing Fiction
Authors: Rudds Crystal S. 
Published: August 2022

Abstract
This essay seeks to expand the genre of black literary urbanism by examining Frank London Brown’s Trumbull Park (1959) and Jasmon Drain’s Stateway’s Garden (2020) as literary bookends of public housing history in the United States. The essay argues that public housing fiction is an understudied subgenre of the black urban narrative that, when surveyed for its historical context, phenomenological perspectives, and diverse literary style, widens literary urbanism’s representation of the structure of feeling within and regarding the built environment of urban space. In addition, this piece works through Elizabeth Alexander’s construct of “the black interior” to explore the ways in which public housing residents might valorize their environs apart from sociological and racialized discourses. Thinking through public housing fiction as an extension of the black urban narrative helps to demystify the nuances of urban spatiality and the range of socioeconomics that propel modern cities.
Effectiveness of seasonal malaria chemoprevention administered in a mass campaign in the Kedougou region of Senegal in 2016: a case-control study
Authors: Manga Isaac Akhenaton , Tairou Fassiatou , Seck Amadou , Kouevidjin Ekoue , Sylla Khadime , Sow Doudou , Gueye Alioune Babara , Ba Mady , Ndiaye Magatte , Tine Roger Clément Kouly , Gaye Omar , Faye Babacar , Ndiaye Jean Louis Abdourahim 
Published: August 2022

Background: Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) is a malaria prevention strategy recommended since 2012 by the World Health Organization (WHO) for children under 5 years. In Senegal, the scaling up of SMC started in 2013 in the south-eastern regions of the country with an extension of the target to 10 years old children. The scaling up of SMC requires regular evaluation of the strategy as recommended by the WHO. This study was conducted to evaluate the effectiveness of SMC. Methods: A case-control study was conducted in some villages of the health districts of Saraya and Kedougou in the Kedougou region from July to December 2016. A case was a sick child, aged 3 months to 10 years, seen in consultation and with a positive malaria rapid diagnostic test (RDT). The control was a child of the same age group with a negative RDT and living in the same compound as the case or in a neighbouring compound. Each case was matched with two controls. Exposure to SMC was assessed by interviewing the mothers/caretakers and by checking the SMC administration card. Results: Overall, 492 children, including 164 cases and 328 controls, were recruited in our study. Their mean ages were 5.32 (+/- 2.15) and 4.44 (+/-2.25) years for cases and controls, respectively. The number of boys was higher in both cases (55.49%; CI 95%=47.54-63.24%) and controls (51,22%; CI 95%=45.83-56.58%). Net ownership was 85.80% among cases and 90.85% among controls (p=0,053). The proportion of controls who received SMC was higher than that of cases (98.17% vs 85.98% and p=1.10-7). The protective effectiveness of SMC was 89% (OR= 0.12 (CI 95%=0.04-0.28)). Conclusions: SMC is an effective strategy in the control of malaria in children. Case-control studies are a good approach for monitoring the efficacy of drugs administered during SMC.
Leadership and Productivity: A Study of U.S. Automobile Assembly Plants
Authors: Giardili Soledad , Ramdas Kamalini , Williams Jonathan W. 
Published: August 2022

We examine the effect of plant managers on productivity using unique matched manager-plant panel data on U.S. auto-assembly plants during 1993–2007. Our econometric approach is two-pronged. Our first approach relies on using the panel nature of our data to measure variation in productivity due to managerial influence. We estimate the interquartile range of the effect of individual plant managers on average hours-per-vehicle to be about 30%. Further, we find that plant managers’ experience with the models that are in production ameliorates the negative impact of new model introductions on productivity. We also observe evidence that managers’ plant-specific tenure has a positive impact on productivity. In our second approach, we use high-frequency time-series data, along with structural-break tests and machine-learning methodologies, to predict variation in production using plant-manager switches. We find that a plant manager’s identity is predictive of changes in both the mean and variance of production, further highlighting their channels of managerial influence. These findings are robust to narrowing the sample to focus on retirements as an exogenous source of managerial switches. This paper was accepted by Serguei Netessine, operations management. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.4427 .
JR2net: a joint non-linear representation and recovery network for compressive spectral imaging
Authors: Monroy Brayan , Bacca Jorge , Arguello Henry 
Published: August 2022

Deep learning models are state-of-the-art in compressive spectral imaging (CSI) recovery. These methods use a deep neural network (DNN) as an image generator to learn non-linear mapping from compressed measurements to the spectral image. For instance, the deep spectral prior approach uses a convolutional autoencoder (CAE) network in the optimization algorithm to recover the spectral image by using a non-linear representation. However, the CAE training is detached from the recovery problem, which does not guarantee optimal representation of the spectral images for the CSI problem. This work proposes a joint non-linear representation and recovery network (JR2net), linking the representation and recovery task into a single optimization problem. JR2net consists of an optimization-inspired network following an alternating direction method of multipliers (ADMM) formulation that learns a non-linear low-dimensional representation and simultaneously performs the spectral image recovery, trained via the end-to-end approach. Experimental results show the superiority of the proposed method with improvements up to 2.57 dB in peak signal-to-noise ratio (PSNR) and performance around 2000 times faster than state-of-the-art methods.
Ultra-efficient diamond plasmonic band-stop filter with enhanced effect
Authors: Zhang Zuoxin , Feng Hengli , Fang Dongchao , Wang Jincheng , Zhang Jingyu , Liu Chang , Wang Guan , Wang Lehui , Ran Lingling , Gao Yang 
Published: August 2022

In this paper, a band-stop filter based on a surface plasmon polariton metal–insulator–metal is designed and studied. The relationship between wavelength and filter transmittance is simulated using the finite difference time domain method and coupled mode theory. Compared with a single-diamond resonator, the minimum transmittances of the double-diamond resonator and double-rectangular resonator at a fixed wavelength are increased by 11.33% and 14.25%, respectively, achieving an enhancement effect. The research results also show that the sensitivity of the filter can reach 860 nm/RIU. The structure has good application prospects in optical integration, optical communication, and optical information processing.
Ultra-broadband origami absorber with large angle stability in the THz region
Authors: Yao Junqi , Gui Di , Zhang Dan , Zhang Haifeng 
Published: August 2022

A three-dimensional origami-structured absorber based on

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is designed. The unit structures of the origami absorber are folded from both sides to the middle, and a cavity is formed. After simulation, it is found that this absorber possesses insensitivity to polarized electromagnetic waves and stability at large incident angles. In addition, the origami absorber exhibits good absorption performance at low frequencies. An absorption band with absorptivity over 0.9 at 0.61–6.5 THz can be formed in TE mode. The coverage of the absorption band exceeds 10 octaves, and the relative bandwidth is 165.7%. In TM mode, the absorption band is located at 0.68–6.5 THz, which exceeds 9.5 octaves, and the relative bandwidth is 162.1%. We demonstrate the absorption mechanism by analyzing the electric field, surface current, and magnetic field distribution.