bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selected stage IV rectal cancer patients managed by the watch‐and‐wait approach after pelvic radiotherapy: a good alternative to total mesorectal excision surgery?
Authors: Custers Petra A. , Hupkens Britt J. P. , Grotenhuis Brechtje A. , Kuhlmann Koert F. D. , Breukink Stéphanie O. , Beets Geerard L. , Melenhorst Jarno ,   the Dutch Watch‐and‐Wait Consortium (collaborators)
Published: January 2022

AbstractAimThe aim of this study was to assess the clinical and oncological outcome of a selected group of stage IV rectal cancer patients managed by the watch‐and‐wait approach following a (near‐)complete response of the primary rectal tumour after radiotherapy.MethodPatients registered in the Dutch watch‐and‐wait registry since 2004 were selected when diagnosed with synchronous stage IV rectal cancer. Data on patient characteristics, treatment details, follow‐up and survival were collected. The 2‐year local regrowth rate, organ‐preservation rate, colostomy‐free rate, metastatic progression‐free rate and 2‐ and 5‐year overall survival were analysed.ResultsAfter a median follow‐up period of 35 months, local regrowth was observed in 17 patients (40.5%). Nine patients underwent subsequent total mesorectal excision, resulting in a permanent colostomy in four patients. The 2‐year local regrowth rate was 39.9%, the 2‐year organ‐preservation rate was 77.1%, the 2‐year colostomy‐free rate was 88.1%, and the 2‐year metastatic progression‐free rate was 46.7%. The 2‐ and 5‐year overall survival rates were 92.0% and 67.5%.ConclusionThe watch‐and‐wait approach can be considered as an alternative to total mesorectal excision in a selected group of stage IV rectal cancer patients with a (near‐)complete response following pelvic radiotherapy. Despite a relatively high regrowth rate, total mesorectal excision and a permanent colostomy can be avoided in the majority of these patients.
Clinical and pathological features of bronchiolitis obliterans requiring lung transplantation in paraneoplastic pemphigus associated with Castleman disease
Authors: Chen Wenhui , Zhao Ling , Guo Lijuan , Zhao Li , Niu Hongtao , Lian Huifang , Dai Huaping , Chen Jingyu , Wang Chen 
Published: January 2022

AbstractSummary at a glanceBronchiolitis obliterans in paraneoplastic pemphigus associated with Castleman disease possesses the progressive nature even when it is treated with intensive medical therapy. Antibodies were at least in low titers before the Lung transplant and remain negative after the procedure. Explanted lungs showed coexistence of cellular destructive bronchiolitis and constrictive bronchiolitis.BackgroundBronchiolitis obliterans (BO) in paraneoplastic pemphigus (PNP) associated with Castleman disease (CD) possesses the progressive nature of pulmonary disease even when it is treated with intensive medical therapy. Lung transplantation (LT) offers an acceptable form of treatment.MethodsWe conducted a retrospective study of two cases of BO in PNP associated with CD who underwent LT between March 2017 and March 2020 at the China‐Japan Friendship Hospital. We also included one case from the literature.ResultsIn this patient series, PNP was the primary clinical presentation in all patients, and it was accompanied by respiratory symptoms before/after CD excision. In spite of being treated with various combinations of immunosuppressive and anti‐inflammatory agents, the patients had great or total improvement in mucosal erosions, whereas their pulmonary function test (PFT) deteriorated gradually or sharply. The duration times from disease onset to timing of LT were 1, 2 and 5 years. All antibodies were negative or were present at low titers before the LT procedure and remain negative after the procedure. The histopathological features of explanted lungs showed cellular and coexistent destructive bronchiolitis and constrictive bronchiolitis in two cases. Granulation with numerous foamy macrophages, scattered giant cells and cholesterol clefts were especially prominent in case one.ConclusionBO in PNP associated with CD had poor clinical outcomes. LT was preferable choice in end‐stage BO when PNP and CD were controlled.
1011. LAUNAEA CERVICORNIS: Compositae
Authors: Hind Nicholas , Moore Richard , King Christabel 
Published: January 2022

SummaryLaunaea cervicornis (Boiss.) Font Quer & Rothm. (Compositae: Lactuceae: Hyoseridinae) is illustrated and described. The species is endemic to the Balearics, and is the dominant species in the limestone cliff‐top plant association Launaeion cervicornis (O. Bolòs & Vigo ex Y. Gil & Llorens) Rivas‐Martínez, Fernández‐González & Loidi) on the islands. Notes on cultivation, propagation, pests and diseases and availability are provided. The position of Launaea Cass. in the tribe Lactuceae (= Cichorieae) subtribe Hyoseridinae Less. is discussed, as is the position of the species within the genus, as the sole taxon in Launaea sect. Cervicornes N. Kilian. The reproductive biology of the species is discussed. The species exhibits a particularly short flowering time (per floret) and flowering period, maximizing on calm periods and an abundance of flower visitors/pollinators. The plant possesses three different dispersal mechanisms – anemochory (for solitary achenes), and atelechory and barochory for mature, unopened involucres. The former ensuring there is some movement away from the parent plant, and the latter two effectively ensuring that propagules are not instantly blown off the cliffs into the sea.
1015. INULA RHIZOCEPHALA: Compositae
Authors: Hind Nicholas , Strange Kit , King Christabel 
Published: January 2022

SummaryInula rhizocephala Schrenk (Compositae: Inuleae: Inulinae) is described and illustrated, together with a commentary on the discovery of Kew's current plant stock. Notes on cultivation, propagation, pests and diseases and availability are provided. It is highly likely that I. rhizocephala is an annual or biennial, or possibly a short‐lived perennial, since no perennating rootstock has been retained in either pot grown or Rock Garden plantings at Kew. The position of Inula rhizocephala in the genus, and within the tribe Inuleae subtribe Inulinae, is discussed. The author citation of the binomial Inula rhizocephala is also discussed as is the type material of I. rhizocephaloides, a synonym of I. rhizocephala, and aspects of the pollen presentation in the disc florets.
Recognition of broad thermal anomaly around the median tectonic line in central Kii peninsula, southwest Japan: Possible heat sources
Authors: Yamaoka Ken , Wallis Simon R. 
Published: January 2022

AbstractApplication of Raman spectroscopy of carbonaceous material thermometry to samples of metasedimentary rock from the low‐grade Sanbagawa belt in the central Kii peninsula reveals a progressive decrease in temperature from ~390 °C close to the northern boundary, a major continental shear zone—the median tectonic line (MTL)—to ~270 °C and ~7 km to the south and roughly constant temperature distribution thereafter. Within the Sanbagawa belt, the thermal structure is not significantly modified by slip‐on fault boundaries between different geological units or folding. Meso‐ and microstructural observations combined with strain analysis using detrital grains in meta‐mudstone indicate a similar deformation history throughout the area and no correlation between ductile strain and temperature gradients. These observations suggest the observed thermal structure was developed after the main stages of ductile deformation of the Sanbagawa belt were complete and are not due to localized preferential exhumation along with the MTL. The observations also require a heat source along with the MTL. Order of magnitude estimates suggest the influx of warm fluid along the MTL are viable causes of the observed thermal anomaly. Although shear heating would be another possible explanation, thermal calculations require anomalous fast slip rates along the MTL and much greater frictional strength than generally considered reasonable. For these reasons, fluid infiltration is our preferred model.
Inculturation as Doctrinal Development: Shaping International Theological Categories
Authors: Kane Ross 
Published: January 2022

Abstract‘Doctrinal development’ and ‘inculturation’ are two of the most common terms in systematic theology for incorporating new ideas into Christian tradition. While these categories often carry geographic and racial associations, this article suggests that doctrinal development and inculturation be understood as distinct though interdependent. Applying these categories internationally, in any geography, makes clear that sometimes inculturation becomes doctrinal development. In discerning such development, the article suggests a distinction between two kinds of inculturation, one that remains geographically or culturally specific and another that could become a doctrinal development for the wider church. It then tests the usefulness of this distinction by applying it to theological proposals of Jürgen Moltmann and Kwame Bediako.
Long‐term renal outcome post‐multimodal computed tomography in stroke evaluation
Authors: Lim Julia , Goh Ian , Gwini Stella‐May , Stringer Felicity , Ng Zun Niang , Dohrmann Sara , Smith Heather , Clissold Benjamin 
Published: January 2022

AbstractRecent studies have demonstrated the risk of contrast‐associated acute kidney injury (CA‐AKI) is low post‐multimodal computed tomography (MMCT) in the evaluation of acute stroke. We provide a complementary study with long‐term renal follow up. A retrospective analysis was performed on all suspected strokes from January 2019 to June 2020 for those who had undergone computed tomography angiography, computed tomography perfusion or both. We identified 776 cases, of which 538 were excluded. The incidence of CA‐AKI was 7.6% (n/N = 18/238; 95% confidence interval = 4.2–11.0). All CA‐AKI cases had renal confounders. No AKI at >30 days was found in 60.5% (n = 144) of all cases studied. The long‐term renal outcome post‐MMCT in stroke evaluation is favourable at >30 days.
The Dark Triad Traits, Humor Styles, and Schadenfreude: Others' Misery as the Devil's Laughing Stocks1
Authors: Yee Jian Wei , Lee Soon Li 
Published: January 2022

AbstractThis research investigated the relationships of the Dark Triad traits, humor styles, and schadenfreude with 169 participants who completed the Short Dark Triad, the Humor Style Questionnaire, and a measure of schadenfreude. Significant correlations imply that those with salient dark traits (psychopathy, Machiavellianism, narcissism) elicit pleasure from others' misfortune. Additionally, schadenfreude can be a product of self‐defeating and aggressive humor styles. Indirect effect analysis revealed the significance of the indirect effect of the measured aggressive humor style on the Dark Triad's direct effects on schadenfreude. These results imply that those with salient Dark Triad traits enjoy others' misery as a means to undermine them. Hence, individuals with salient Dark Triad traits tend to engage in downward social comparison.
Risk factors for hospitalization among adults aged ≥65 years with non‐typhoidal Salmonella infection linked to backyard poultry contact
Authors: Whitehill Florence M. , Stapleton G. Sean , Koski Lia , Sievert Dawn , Nichols Megin 
Published: January 2022

AbstractObjectiveWe describe the epidemiology of live poultry‐associated salmonellosis (LPAS) and investigate potential risk factors associated with hospitalization among adults aged ≥65 years in the United States during 2008–2017. LPAS is a public health concern in the United States, especially among people with increased risk for hospitalization, such as older adults.SampleWe analysed data from people aged ≥65 years with non‐typhoidal salmonellosis who reported live poultry contact within seven days prior to illness onset.ProcedureWe used logistic regression to estimate the odds of hospitalization associated with several risk factors including types of live poultry contact exposures.ResultsLPAS among older adults in this analysis resulted in high hospitalization rates. Salmonella Hadar infection was associated with increased hospitalization. Among older adults with LPAS, 109 individuals of 127 (86%) reported contact with live poultry at their or someone else's residence, and 85 of 105 with available information (81%) reported owning poultry.Conclusions and Clinical RelevanceAdditional infection prevention information and education targeted at poultry‐owning older adults are needed to prevent illness and hospitalization.
Experimental and Numerical Study of Turbine Blade Fatigue Based on a Creep-Fatigue Prediction Model
Authors: Sun Debin , Huo Junzhou , An Shaoxia 
Published: January 2022

Abstract
To scrupulously predict the creep-fatigue life of materials, a creep life prediction model is first proposed in this study considering real-time creep damage derived from the Kachanov creep damage model; second, combined with the Chaboche fatigue damage model and the nonlinear coupling mechanism of continuous damage mechanics, a creep-fatigue life prediction model of material is ulteriorly presented in this paper; finally, the effectiveness of the creep-fatigue life model is corroborated by experiment data of DZ125, whose prediction results are in the ± 2.0 dispersion zone and then the creep-fatigue life of the turbine blade is calculated to compare with the experimental results of the blade specimen to further prove the practicability, whose error is about 3.2%, which can provide a theoretical reference for the damage prediction, durability analysis, and life prediction of the turbine blade.
An Improved Levenberg–Marquardt Approach With a New Reduced Form for the Identification of Parameters of the One-Diode Photovoltaic Model
Authors: Tchakpedeou Abdoul-Baki , Lare Yendoubé , Napo Kossi , Fousseni Arafat 
Published: January 2022

Abstract
Building a highly accurate model for solar cells and photovoltaic (PV) modules based on experimental data is becoming increasingly important for the simulation, evaluation, control, and optimization of PV systems. Powerful, accurate, and more robust optimization algorithms are needed to solve this problem. In this study, a new optimization approach based on the Levenberg–Marquardt algorithm (ImLM) is proposed to estimate the parameters of PV cells and modules and simulate their electrical behavior under all environmental conditions efficiently and accurately. To avoid the premature convergence of the Levenberg–Marquardt algorithm and the long computation time caused by a bad choice of initial values, we propose a new approach. This is a new reduced form leading to a nonlinear relationship of the series resistance and thus allowing to calculate the optimal initial values of the model parameters. Comparisons with other published methods show that the proposed approach gives not only a more accurate final solution but also a fast convergence speed and a better stability. Furthermore, tests on three PV modules of different technologies (multi-crystalline, thin film, and monocrystalline) reveal that the proposed algorithm performs well at different irradiations and temperatures. These results confirm that the ImLM approach is a valuable tool and can be an effective and efficient alternative for extracting PV model parameters and simulating PV module behavior under different conditions.
A New Two-Stage Degradation Model for the Preload of Linear Motion Ball Guide Considering Machining Errors
Authors: Wang Xiao-Yi , Feng Hu-Tian , Zhou Chang-Guang , Chen Zeng-Tao , Xie Jing-Lun 
Published: January 2022

Abstract
Preload, which is widely applied in linear motion ball guide (LMBG) to eliminate clearance and increase stiffness, gradually decreases owing to wear, resulting in the degradation of the load-bearing capability and dynamic response of LMBG. However, no solution can be found on the modeling of the preload degradation of LMBG considering raceway profile error, ball diameter error, etc. Therefore, this paper presented a new two-stage degradation model to predict the preload variation of LMBG with considering machining errors. The model was experimentally verified with the prediction accuracy much higher than the model considering no machining errors at either of the two wear stages, which demonstrates the effectiveness of considering machining errors. Additionally, the effects of waviness errors, external load, and feed speed on the preload degradation of LMBG were discussed. The simulation results indicate that the preload loss rate rises with the increase of waviness error, external load and feed speed. For obtaining a longer effective service life of LMBG, it is helpful to select appropriate external load and feed speed conditions and improve the processing technique as well as the machined surface quality.
Primary Parametric Amplification in a Weakly Forced Mathieu Equation
Authors: Ramakrishnan Venkatanarayanan , Feeny Brian F. 
Published: January 2022

Abstract
The present study deals with the response of a forced Mathieu equation with damping, with weak harmonic direct excitation at the same frequency as the parametric excitation. A second-order perturbation analysis using the method of multiple scales unfolds parametric amplification at primary resonance. The parametric effect on the primary resonance behavior occurs with a slow time scale of second-order, although the effect on the steady-state response is of order 1. As the parametric excitation level increases, the response at primary resonance stretches before becoming unbounded and unstable. Analytical expressions for predicting the response amplitudes are presented and compared with numerical results for a specific set of system parameters. Dependence of the amplification behavior, and indeed possible deamplification, on parameters is examined. The effect of parametric excitation on the response phase behavior is also presented.
Optimal number and orientation of anterior segment OCT images to measure ocular biometric parameters in angle closure eyes: the Chinese American Eye Study
Authors: Shan Jing , Pardeshi Anmol , Jiang Xuejuan , Richter Grace M , McKean-Cowdin Roberta , Varma Rohit , Xu Benjamin Y 
Published: January 2022

PurposeTo assess the optimal number and orientation of anterior segment optical coherence tomography (AS-OCT) images for accurately measuring ocular biometric parameters in angle closure eyes.MethodsSubjects with angle closure, defined as>3 quadrants of non-visible pigmented trabecular meshwork on static gonioscopy, were selected from the Chinese American Eye Study. Mean angle opening distance (AOD500) was calculated using four images (0°−180°, 45°−225°, 90°−270° and 135°−315° meridians) from one eye per subject. Ten eyes from each quartile of AOD500 measurements were randomly selected for detailed 32-image analysis of 10 biometric parameters, including AOD500, iris curvature (IC), anterior chamber depth (ACD), lens vault (LV), and anterior chamber area (ACA). Mean and range of measurements from 1, 2, 4, 8 or 16 images were compared with 32-image values for all parameters.Results40 out of 335 eyes with angle closure were selected for 32-image analysis. Deviation from the 32-image mean was between 0.44% and 19.31% with one image, decreasing to 0.08% to 4.21% with two images for all parameters. Deviation from the 32-image range of measurements was between 54.67% to 88.94% with one image, decreasing to <7.00% with eight images for all parameters except ACD and ACA. Orienting the first image analysed along the 25°−205° meridian better approximated the range of measurements when four or fewer images were analysed.ConclusionsSectoral anatomical variations in angle closure eyes are easily misrepresented based on current AS-OCT imaging conventions. A revised multi-image approach can better capture the mean and range of biometric measurements.
Validity of ICD-10 codes for COVID-19 patients with hospital admissions or ED visits in Canada: a retrospective cohort study
Authors: Wu Guosong , D'Souza Adam G , Quan Hude , Southern Danielle A , Youngson Erik , Williamson Tyler , Eastwood Cathy , Xu Yuan 
Published: January 2022

ObjectiveTo evaluate the validity of COVID-19 International Classification of Diseases, 10th Revision (ICD-10) codes and their combinations.DesignRetrospective cohort study.SettingAcute care hospitals and emergency departments (EDs) in Alberta, Canada.ParticipantsPatients who were admitted to hospital or presented to an ED in Alberta, as captured by local administrative databases between 1 March 2020 and 28 February 2021, who had a positive COVID-19 test and/or a COVID-19-related ICD-10 code.Main outcome measuresThe sensitivity, positive predictive value (PPV) and 95% CIs for ICD-10 codes were computed. Stratified analysis on age group, sex, symptomatic status, mechanical ventilation, hospital type, patient intensive care unit (ICU) admission, discharge status and season of pandemic were conducted.ResultsTwo overlapping subsets of the study population were considered: those who had a positive COVID-19 test (cohort A, for estimating sensitivity) and those who had a COVID-19-related ICD-10 code (cohort B, for estimating PPV). Cohort A included 17 979 ED patients and 6477 inpatients while cohort B included 33 675 ED patients and 18 746 inpatients. Of inpatients, 9.5% in cohort A and 8.1% in cohort B received mechanical ventilation. Over 13% of inpatients were admitted to ICU. The length of hospital stay was 6 days (IQR: 3–14) for cohort A and 8 days (IQR: 3–19) for cohort B. In-hospital mortality was 15.9% and 38.8% for cohort A and B, respectively. The sensitivity for ICD-10 code U07.1 (COVID-19, virus identified) was 82.5% (81.8%–83.2%) with a PPV of 93.1% (92.6%–93.6%). The combination of U07.1 and U07.3 (multisystem inflammatory syndrome associated with COVID-19) had a sensitivity of 82.5% (81.9%–83.2%) and PPV of 92.9% (92.4%–93.4%).ConclusionsIn Alberta, ICD-10 COVID-19 codes (U07.1 and U07.3) were coded well with high validity. This indicates administrative data can be used for COVID-19 research and pandemic management purposes.
Pandemonium: a clustering tool to partition parameter space—application to the B anomalies
Authors: Laa Ursula , Valencia German 
Published: January 2022

AbstractWe introduce the interactive tool to cluster model predictions that depend on a set of parameters. The model predictions are used to define the coordinates in observable space which go into the clustering. The results of this partitioning are then visualized in both observable and parameter space to study correlations between them. The tool offers multiple choices for coordinates, distance functions and linkage methods within hierarchical clustering. It provides a set of diagnostic statistics and visualization methods to study the clustering results in order to interpret the outcome. The methods are most useful in an interactive environment that enables exploration, and we have implemented them with a graphical user interface in R. We demonstrate the concepts with an application to phenomenological studies in flavor physics in the context of the so-called B anomalies, exploring the tension between $$P_5^\prime $$

P
5
′

and $$R_K$$

R
K

and quantifying the resolution in parameter space that can be provided by a given observable set.