bluuebunny/crossref_metadata_2025_split huggingface dataset:
MANAJEMEN KONFLIK DALAM ORGANISASI: KONFLIK KEPERCAYAAN DALAM ORGANISASI GEREJA BFA BANDUNG
Authors: Mahardika Mahardika , Maryani Eni , Rizal Edwin 
Published: March 2022

Gereja sebagai sebuah unit religius di masyarakat sering dipandang sebagai sesuatu yang suci dan terhindar dari konflik. Akan tetapi dalam praktiknya sebagai organisasi keagamaan, gereja juga dapat mengalami konflik dalam interaksi sosial di dalamnya. Untuk memahami konflik yang terjadi di gereja penelitian ini merujuk teori komunikasi organisasi dan teori agama dalam konteks sosial. Kasus di dalam penelitian ini adalah Gereja Bethany Fresh Anointing (BFA) di Bandung yang mengalami konflik di dalam organisasinya. Penelitian ini bertujuan untuk mengelaborasi manajemen konflik yang dilakukan Gereja dalam menangani konflik yang terjadi di dalam organisasinya sebagai organisasi keagamaan. Penelitian ini merupakan studi kasus dengan pengumpulan data melalui wawancara mendalam dan observasi. Hasil penelitian menunjukan bahwa melalui manajemen konflik yang dilakukan pihak gereja maka konflik dijadikan sebagai alat untuk melakukan evaluasi organisasi sehingga gereja mampu mengatasi kendala yang dihadapi, memperbaiki kinerjanya, dan meningkatkan efisiensi dalam pelayanannya. Manajemen konflik yang dilakukan juga memerlukan strategi komunikasi yang sesuai dengan budaya komunikasi dan organisasi di dalam Gereja Bethany Fresh Anointing sebagai organisasi keagamaan.
TESS Hunt for Young and Maturing Exoplanets (THYME). VI. An 11 Myr Giant Planet Transiting a Very-low-mass Star in Lower Centaurus Crux
Authors: Mann Andrew W. , Wood Mackenna L. , Schmidt Stephen P. , Barber Madyson G. , Owen James E. , Tofflemire Benjamin M. , Newton Elisabeth R. , Mamajek Eric E. , Bush Jonathan L. , Mace Gregory N. , Kraus Adam L. , Thao Pa Chia , Vanderburg Andrew , Llama Joe , Johns-Krull Christopher M. , Prato L. , Stahl Asa G. , Tang Shih-Yun , Fields Matthew J. , Collins Karen A. , Collins Kevin I. , Gan Tianjun , Jensen Eric L. N. , Kamler Jacob , Schwarz Richard P. , Furlan Elise , Gnilka Crystal L. , Howell Steve B. , Lester Kathryn V. , Owens Dylan A. , Suarez Olga , Mekarnia Djamel , Guillot Tristan , Abe Lyu , Triaud Amaury H. M. J. , Johnson Marshall C. , Milburn Reilly P. , Rizzuto Aaron C. , Quinn Samuel N. , Kerr Ronan , Ricker George R. , Vanderspek Roland , Latham David W. , Seager Sara , Winn Joshua N. , Jenkins Jon M. , Guerrero Natalia M. , Shporer Avi , Schlieder Joshua E. , McLean Brian , Wohler Bill 
Published: March 2022

Abstract
Mature super-Earths and sub-Neptunes are predicted to be ≃ Jovian radius when younger than 10 Myr. Thus, we expect to find 5–15 R
⊕ planets around young stars even if their older counterparts harbor none. We report the discovery and validation of TOI 1227b, a 0.85 ± 0.05 R
J (9.5 R
⊕) planet transiting a very-low-mass star (0.170 ± 0.015 M
⊙) every 27.4 days. TOI 1227's kinematics and strong lithium absorption confirm that it is a member of a previously discovered subgroup in the Lower Centaurus Crux OB association, which we designate the Musca group. We derive an age of 11 ± 2 Myr for Musca, based on lithium, rotation, and the color–magnitude diagram of Musca members. The TESS data and ground-based follow-up show a deep (2.5%) transit. We use multiwavelength transit observations and radial velocities from the IGRINS spectrograph to validate the signal as planetary in nature, and we obtain an upper limit on the planet mass of ≃0.5 M
J. Because such large planets are exceptionally rare around mature low-mass stars, we suggest that TOI 1227b is still contracting and will eventually turn into one of the more common <5 R
⊕ planets.
Recurrent Strong Outbursts of an EXor-like Young Eruptive Star Gaia20eae
Authors: Cruz-Sáenz de Miera Fernando , Kóspál Ágnes , Ábrahám Péter , Park Sunkyung , Nagy Zsófia , Siwak Michał , Kun Mária , Fiorellino Eleonora , Szabó Zsófia Marianna , Antoniucci Simone , Giannini Teresa , Nisini Brunella , Szabados László , Kriskovics Levente , Ordasi András , Szakáts Róbert , Vida Krisztián , Vinkó József , Zieliński Paweł , Wyrzykowski Łukasz , García-Álvarez David , Dróżdż Marek , Ogłoza Waldemar , Sonbas Eda 
Published: March 2022

Abstract
We present follow-up photometric and spectroscopic observations, and subsequent analysis of Gaia20eae. This source triggered photometric alerts during 2020 after showing a ∼3 mag increase in its brightness. Its Gaia Alert light curve showed the shape of a typical eruptive young star. We carried out observations to confirm Gaia20eae as an eruptive young star and classify it. Its pre-outburst spectral energy distribution shows that Gaia20eae is a moderately embedded Class II object with L
bol = 7.22 L
⊙. The color–color and color–magnitude diagrams indicate that the evolution in the light curve is mostly gray. Multiple epochs of the Hα line profile suggest an evolution of the accretion rate and winds. The near-infrared spectra display several emission lines, a feature typical of EX Lupi-type (EXor) eruptive young stars. We estimated the mass accretion rate during the dimming phase to be

M
˙

= 3–8 × 10−7
M
⊙ yr−1, higher than typical T Tauri stars of similar mass and comparable to other EXors. We conclude Gaia20eae is a new EXor-type candidate.
Radius Constraints from Reflection Modeling of Cygnus X-2 with NuSTAR and NICER
Authors: Ludlam R. M. , Cackett E. M. , García J. A. , Miller J. M. , Stevens A. L. , Fabian A. C. , Homan J. , Ng M. , Guillot S. , Buisson D. J. K. , Chakrabarty D. 
Published: March 2022

Abstract
We present a spectral analysis of NuSTAR and NICER observations of the luminous, persistently accreting neutron star (NS) low-mass X-ray binary Cygnus X-2. The data were divided into different branches that the source traces out on the Z-track of the X-ray color–color diagram; namely, the horizontal branch, the normal branch, and the vertex between the two. The X-ray continuum spectrum was modeled in two different ways that produced comparable quality fits. The spectra showed clear evidence of a reflection component in the form of a broadened Fe K line, as well as a lower-energy emission feature near 1 keV likely due to an ionized plasma located far from the innermost accretion disk. We account for the reflection spectrum with two independent models (relxillns and rdblur*rfxconv). The inferred inclination is in agreement with earlier estimates from optical observations of ellipsoidal lightcurve modeling (relxillns: i = 67° ± 4°; rdblur*rfxconv: i = 60° ± 10°). The inner disk radius remains close to the NS (R
in ≤ 1.15 R
ISCO) regardless of the source position along the Z-track or how the 1 keV feature is modeled. Given the optically determined NS mass of 1.71 ± 0.21 M
⊙, this corresponds to a conservative upper limit of R
in ≤ 19.5 km for M = 1.92 M
⊙ or R
in ≤ 15.3 km for M = 1.5 M
⊙. We compare these radius constraints to those obtained from NS gravitational wave merger events and recent NICER pulsar lightcurve modeling measurements.
A Brightness Classification Boundary in the Kuiper Belt Population
Authors: Napier Kevin J. , Adams Fred C. 
Published: March 2022

Abstract
The Kuiper Belt contains a large number of minor bodies that collectively constrain the dynamical history of the solar system. These bodies are often classified into distinct populations. This note identifies a well-defined boundary (at H-magnitude = 5.65) that separates bright (large) objects from dimmer (smaller) objects. The probability that the two sub-samples are drawn from the same underlying distribution is p ∼ 10−15. The larger bodies (estimated radius R ≳ 125 km) are dynamically hot, as measured by their locations in the e-

sin
i

plane, and likely represent an implanted population. The smaller bodies (R ≲ 125 km) are dynamically colder and are likely to be primordial. The bright/large/hot population currently contains ∼200 members, including all ∼50 dwarf planet candidates in the Kuiper Belt.
New Constraints on Titan’s Stratospheric n-Butane Abundance
Authors: Steffens Brendan L. , Nixon Conor A. , Sung Keeyoon , Irwin Patrick G. J. , Lombardo Nicholas A. , Pereira Eric 
Published: March 2022

Abstract
Curiously, n-butane has yet to be detected at Titan, though it is predicted to be present in a wide range of abundances that span over 2.5 orders of magnitude. We have searched infrared spectroscopic observations of Titan for signals from n-butane (n-C4H10) in Titan’s stratosphere. Three sets of Cassini Composite Infrared Spectrometer Focal Plane 4 (1050–1500 cm−1) observations were selected for modeling, having been collected from different flybys and pointing latitudes. We modeled the observations with the Nonlinear Optimal Estimator for MultivariatE Spectral AnalySIS radiative transfer tool. Temperature profiles were retrieved for each of the data sets by modeling the ν
4 emission from methane near 1305 cm−1. Then, incorporating the temperature profiles, we retrieved abundances of all of Titan’s known trace gases that are active in this spectral region, reliably reproducing the observations. We then systematically tested a set of models with varying abundances of n-butane, investigating how the addition of this gas affected the fits. We did this for several different photochemically predicted abundance profiles from the literature, as well as for a constant-with-altitude profile. Ultimately, though we did not produce any firm detection of n-butane, we derived new upper limits on its abundance specific to the use of each profile and to multiple different ranges of stratospheric altitudes. These results will tightly constrain the C4 chemistry of future photochemical modeling of Titan’s atmosphere and also motivate the continued search for n-butane and its isomer, isobutane.
Mobile Health Application to Support Family Caregivers in Recurrent Stroke Prevention: Scoping Review
Authors: Firmawati Erfin , Setyopanoto Ismail , Pangastuti Heny Suseani 
Published: March 2022

BACKGROUND OF THE STUDY: Caregivers play a vital role in continuum care for stroke patients. Involvement of caregivers in stroke care was important. With the advancement of information technology and the rapid growth worldwide in cell-phone use and internet connectivity, additional evidence may be needed in the use of mobile applications to support caregivers in stroke care.
AIM OF THE STUDY: The aims of this review was to identify existing mobile application designed to support family caregivers of people with stroke disease.
METHODOLOGY: A scoping review study framework was carried out in this study, using the EBSCO, Cochrane, PubMed, ProQuest, and Science Direct databases using search keywords: ‘family caregiver’, ‘mobile health application’, and ‘recurrent stroke or secondary stroke prevention’. This review examined studies published between January 2011 and December 2020. Of a total of 728 papers found, 9 journals were selected. RESULTS: The results founded three categories and their attendant sub-categories. The categories was caregivers support, involvement caregivers in stroke care, and barriers. The majority of mobile application was used to provide video education for caregivers. Caregivers involved in stroke care including emotional care, nutrition, exercise, and recurrent stroke prevention. Poor connection was the most barrier in using mobile application.
CONCLUSION: Mobile application can support caregivers in stroke care. Healthcare providers are expected to utilize mobile applications in helping caregivers in post-stroke care.
Comparison Between the Effect of Low-Energy Laser Application and Piezocision on Acceleration of Orthodontic Tooth Movement
Authors: Al Sherbiny Ahmad Helal , Refai Wael Mohamed Mubarak , Mohamed Kareem M. , Elhiny Omnia A. , Nasef Ahmed 
Published: March 2022

ABSTRACT the aim of the study was to study the effectiveness of Low Energy Laser Application or piezocisions in accelerating tooth movement, during canine retraction, compared to conventional canine retraction. Patients and Methods: A split mouth study design was done with two groups A and B. Each group confined 10 patients; in each patient one side was used as a control side and the contralateral side received either low-level laser therapy (LLLT) (group A) or piezocisions (group B). The evaluation data was gathered by Intra-oral measurements directly, every 2 weeks, over a 3 months retraction period. Results: Statistical analysis using Repeated measure ANOVA test was used to compare between more than two groups in related samples. Paired sample t-test was used to compare between two groups in related samples. Independent sample t-test was used to compare between two groups in non-related samples. direct intra-oral measurements from Group A illustrated that there was a statistically significant difference between the study and control sides (p<0.001) a total of 4.19 ± 0.5 mm canine retraction has been achieved in the low-level laser therapy (LLLT) assisted canine retraction side versus a 2.83 ± 0.2 mm total canine retraction in the control side. which was statistically significant. Group B illustrated that there was a statistically significant difference between the study and control sides ( p<0.001) that a total of 3.65± 0.4 mm canine retraction has been achieved in the piezocisions assisted canine retraction side versus a 2.79± 0.2 mm total canine retraction in the control side which was a highly statistically significant difference Conclusion: low-level laser therapy (LLLT) and Piezocisions techniques accelerated the rate of canine retraction during orthodontic treatment, with the low-level laser therapy (LLLT) being slightly more effective.
The Antimicrobial Effectiveness of Chitosan and Polysaccharide of Durian Peel Extract against Mycobacterium tuberculosis Isolates
Authors: Sutanto Yusup Subagio , Harti Agnes Sri , Sutanto Magdalena , Puspawati Nony 
Published: March 2022

BACKGROUND: Tuberculosis (TB) disease is an infection caused by Mycobacterium tuberculosis and is transmitted through sputum droplets of sufferers or suspect TB in the air. Chitosan as an antimicrobial agent can be used in the biomedical field because it has a number of hydroxyl groups (OH) and amine groups (NH2). The chemical substance of durian peel extract (Durio zibethinus L.) contains pectin which is multifunctional and can be used in the pharmaceutical field. Chemically, pectin is a polysaccharide polymer of D-galacturonic acid linked by -1,4 glycosidic bonds which can dissolve in water to form colloidal solutions or gels. AIM: This study was to determine the antimicrobial effectiveness of chitosan and polysaccharides from durian peel extract (D. zibethinus L.) against M. tuberculosis isolates in vitro. METHODS: The research method is based on an experimental study in vitro. M. tuberculosis isolates in this research from sputum samples of patients suspected of TB in Surakarta Regional General Hospital. The stages of the research were performed that preparation chitosan gel (CG), bioformulation of CG, and polysaccharide gel (PG) durian peel extract are 5%, 10%, 15%, 20%, and 25%, and drug susceptibility testing against M. tuberculosis isolates. RESULTS: CG 10% was effective as an antimicrobial against M. tuberculosis isolates but PG durian peel extract (5%; 10%; 15%; 20%; and 25%) was not effective as an antimicrobial against M. tuberculosis isolates. The types of anti-tuberculosis drug (ATD) that was effective against M. tuberculosis isolates were ethambutol 80% and streptomycin 40%, while isoniazid and rifampicin were not effective as ATD against M. tuberculosis isolates. CONCLUSION: CG 10% was effective as an antimicrobial against M. tuberculosis isolates, while PG 25% durian peel extract was not effective as an antimicrobial against M. tuberculosis isolates. CG has the potential as an ATD based on natural bioactive ingredients for TB therapy.
Health Insurance Literacy Levels of Information Intermediaries: How Prepared Are They to Address the Growing Health Insurance Access Needs of Consumers?
Authors: Edward Jean , Thompson Robin A. , Wiggins Amanda 
Published: March 2022

Background:
With rising unemployment rates brought on by coronavirus disease 2019 pandemic, the rates of underinsured and uninsured consumers are likely to rise. Health information intermediaries play a critical role in assisting consumers with navigating the complexities of the United States health care system and the ever-changing health care policy landscape. Not much is known about the health insurance literacy (HIL) levels of information intermediaries and their ability to assist consumers with making informed decisions about their health insurance.

Objective:
This study aimed to examine the association between information intermediary levels of HIL, sociodemographic factors, and confidence and behaviors in assisting consumers with health insurance needs.

Methods:
We surveyed 118 information intermediaries from various roles to assess objective and subjective HIL, frequency, and confidence in assisting consumers, and confidence in understanding changes in federal health reform policies and state Medicaid waiver programs.

Key Results:
Less than one-half (39%) of information intermediaries had high subjective HIL and much fewer (13%) had high objective HIL. The average frequency of assisting consumers with health insurance scores were somewhat low, and confidence in assisting consumers with health insurance scores and confidence with understanding state and federal policies were modest. Results from our logistic regression model indicated that confidence in assisting consumers was found to be the only significant contributor to high subjective HIL. For every one-point increase on the confidence assisting subscale, there was a 35% increase in the information intermediaries having high subjective HIL.

Conclusions:

Findings from this study, coupled with rising uninsured rates, indicate the need for tailored training programs and resources to equip our information intermediaries to provide timely and appropriate health insurance support for consumers. [

HLRP: Health Literacy Research and Practice
. 2022;6(1):e30–e36.

]

Plain Language Summary:
In a sample of 118 information intermediaries, representing community health workers, navigators, and other people in outreach roles, the majority had low subjective and objective HIL. We also found that as confidence with assisting consumers with health insurance needs increases, HIL increased as well. These findings indicate that tailored training programs and resources are needed to equip information intermediaries to provide health insurance support for consumers.
CRISPR/Cas9-Mediated Insertion of HIV Long Terminal Repeat within BACH2 Promotes Expansion of T Regulatory–like Cells
Authors: Christian Michelle L , Dapp Michael J , Scharffenberger Samuel C , Jones Hank , Song Chaozhong , Frenkel Lisa M , Krumm Anthony , Mullins James I , Rawlings David J 
Published: March 2022

Abstract
One key barrier to curative therapies for HIV is the limited understanding of HIV persistence. HIV provirus integration sites (ISs) within BACH2 are common, and almost all sites mapped to date are located upstream of the start codon in the same transcriptional orientation as the gene. These unique features suggest the possibility of insertional mutagenesis at this location. Using CRISPR/Cas9-based homology-directed repair in primary human CD4+ T cells, we directly modeled the effects of HIV integration within BACH2. Integration of the HIV long terminal repeat (LTR) and major splice donor increased BACH2 mRNA and protein levels, altered gene expression, and promoted selective outgrowth of an activated, proliferative, and T regulatory–like cell population. In contrast, introduction of the HIV-LTR alone or an HIV-LTR-major splice donor construct into STAT5B, a second common HIV IS, had no functional impact. Thus, HIV LTR-driven BACH2 expression modulates T cell programming and leads to cellular outgrowth and unique phenotypic changes, findings that support a direct role for IS-dependent HIV-1 persistence.
T Cell–Specific Deletion of TRAIL Receptor Reveals Its Critical Role for Regulating Pathologic T Cell Activation and Disease Induction in Experimental Autoimmune Encephalomyelitis
Authors: Chyuan I-Tsu , Chu Ching-Liang , Hsu Chia-Lang , Pan Meng-Hsun , Liao Hsiu-Jung , Wu Chien-Sheng , Hsu Ping-Ning 
Published: March 2022

Abstract
Recent evidence from several autoimmune animal models has demonstrated that TRAIL suppresses the activation of T cells and inhibits autoimmune inflammation via an apoptosis-independent pathway. However, it remains unclear whether the immunosuppressive effects of TRAIL are dependent on its direct effects on T cells or on other immune cells to regulate T cells for the induction of disease. Therefore, we generated mice with T cell–specific TRAIL receptor (TRAIL-R) conditional knockout to investigate the impact of TRAIL on autoimmune inflammation and disease induction in experimental autoimmune encephalomyelitis (EAE). T cell–specific TRAIL-R knockout mice were found to completely reverse the TRAIL-mediated suppression of inflammation and disease induction, indicating that TRAIL-R on T cells is essential for TRAIL-mediated suppression of inflammation and disease induction in EAE. Moreover, the immune suppression effects were not due to the induction of cell apoptosis, but to the direct inhibition of T cell activation. In addition, RNA sequencing and transcriptome analysis revealed that TRAIL-R signaling significantly downregulated the genes involved in TCR signaling pathways, T cell differentiation, and proinflammatory cytokines. These results indicate that TRAIL-R on T cells is critical for pathologic T cell activation and induction of inflammation in EAE, suggesting that TRAIL-R serves as a novel immune checkpoint receptor in T cell–mediated autoimmune diseases.
Fluvoxamine for the Early Treatment of COVID-19: A Meta-analysis of Randomized Clinical Trials
Authors: Guo Christina M. , Harari Ofir , Chernecki Cameron , Thorlund Kristian , Forrest Jamie I. 
Published: March 2022

ABSTRACT.
Fluvoxamine is widely prescribed as an antidepressant. Recent studies show the drug may have a clinical benefit in treating COVID-19. We aimed to perform a meta-analysis of the existing randomized trials of fluvoxamine compared with placebo on the early treatment of COVID-19 patients. We included only randomized clinical trials enrolling ambulatory patients with early-stage disease (symptoms < 7 days) for the prevention of hospitalization. We searched MEDLINE and clinicaltrials.gov databases to identify trials and extract data with clarifications from the study investigators. We performed a fixed-effects meta-analysis and sensitivity analyses via R to evaluate the pooled estimate of hospitalization. We included three randomized trials: STOP COVID 1 and 2, and the TOGETHER Trial. The studies included a total of 2,196 patients. The STOP COVID trials measured clinical deterioration whereas the TOGETHER Trial measured hospitalization as the primary outcome. All trials reported on hospitalization up to day 28. The meta-analysis results show that patients receiving fluvoxamine were 31% less likely to experience clinical deterioration or hospitalization compared with placebo (risk ratio, 0.69; 95% CI, 0.54–0.88). A sensitivity analysis using the definition of hospitalization resulted in a risk reduction of 21% (95% CI, 0.60–1.03). Data from three randomized controlled trials show that fluvoxamine was associated with a reduction in the primary outcome measure (either clinical deterioration or composite outcome of hospitalization or extended emergency setting observation), although analysis of hospitalization-only was not statistically significant. More evidence from future trials is still needed to support the findings of this meta-analysis.