bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors and outcomes associated with type of uterine rupture
Authors: Dimitrova D. , Kästner AL. , Kästner AN. , Paping A. , Henrich W. , Braun T. 
Published: March 2022

Abstract
Purpose
To identify risk factors associated with the occurrence of complete uterine rupture (CUR) in comparison to partial uterine rupture (PUR) to further investigate to what extent a standardized definition is needed and what clinical implications can be drawn.

Methods
Between 2005 and 2017 cases with CUR and PUR at Charité University Berlin, Germany were retrospectively identified. Demographic, obstetric and outcome variables were analyzed regarding the type of rupture. Binary multivariate regression analysis was conducted to identify risk factors associated with CUR. In addition, the intended route of delivery (trial of labor after cesarean delivery (TOLAC) and elective repeat cesarean delivery (ERCD)), divided according to the type of rupture, was compared.

Results
92 cases with uterine rupture were identified out of a total of 64.063 births (0.14%). Puerperal complications were more frequent in CUR (67.9 versus 41.1%, p = 0.021). Multiparity ≥ 3 was more frequent in CUR (31 versus 10.7%, p = 0.020). Factors increasing the risk for CUR were parity ≥ 3 (OR = 3.8, p = 0.025), previous vaginal birth (OR = 4.4, p = 0.011), TOLAC (OR = 6.5, p < 0.001) and the use of oxytocin (OR = 2.9, p = 0.036). After multivariate analysis, the only independent risk factor associated with CUR was TOLAC (OR = 7.4, p = 0.017).

Conclusion
TOLAC is the only independent risk factor for CUR. After optimized antenatal counselling TOLAC and ERCD had comparable short-term maternal and fetal outcomes in a high resource setting. A high number of previous vaginal births does not eliminate the risk of uterine rupture. A clear distinction between CUR and PUR is essential to ensure comparability among studies.
Eoarchean subduction-like magmatism recorded in 3750 Ma mafic–ultramafic rocks of the Ukaliq supracrustal belt (Québec)
Authors: Grocolas Thomas , Bouilhol Pierre , Caro Guillaume , Mojzsis Stephen J. 
Published: March 2022

AbstractOur understanding of the nature of crustal formation in the Eoarchean is limited by the scarcity and poor preservation of the oldest rocks and variable and imperfect preservation of protolith magmatic signatures. These limitations hamper our ability to place quantitative constraints on thermomechanical models for early crustal genesis and hence on the operative geodynamic regimes at that time. The recently discovered ca. 3.75 Ga Ukaliq supracrustal enclave (northern Québec) is mainly composed of variably deformed and compositionally diverse serpentinized ultramafic rocks and amphibolitized mafic schists whose metamorphic peak, inferred from phase equilibria modeling, was below 720 °C. Inferred protoliths to the Ukaliq ultramafic rocks include cumulative dunites, pyroxenites, and gabbros, whereas the mafic rocks were probably picrites, basalts, and basaltic andesites. The bulk-rock and mineral chemistry documents the partial preservation of cumulative pyroxenes and probably amphiboles and demonstrates the occurrence of a clinopyroxene-dominated, tholeiitic suite and an orthopyroxene-dominated, boninite-like suite. Together with the presence of negative μ142Nd anomalies in the boninitic basalts, two liquid lines of descent are inferred: (i) a damp tholeiitic sequence resulting from the fractionation of a basaltic liquid produced by mantle decompression; and (ii) a boninitic suite documenting the evolution of an initially primitive basaltic andesite liquid produced by flux melting. Petrographic observations, thermodynamic modeling, bulk-rock and mineral chemistry, and 142Nd isotopic compositions identify the Ukaliq supracrustal belt as the remnant of an Eoarchean arc crust produced by the recycling of Hadean crust in a similar way as modern-style subduction.
Plasma neurofilament light chain as a biomarker of Alzheimer’s disease in Subjective Cognitive Decline and Mild Cognitive Impairment
Authors: Giacomucci Giulia , Mazzeo Salvatore , Bagnoli Silvia , Ingannato Assunta , Leccese Deborah , Berti Valentina , Padiglioni Sonia , Galdo Giulia , Ferrari Camilla , Sorbi Sandro , Bessi Valentina , Nacmias Benedetta 
Published: March 2022

Abstract
Introduction
Neurofilament light chain (NfL) is becoming increasingly notable in neurological diseases including AD, and it has been suggested as a new peripherical biomarker of neurodegeneration. We aimed to compare plasma NfL levels among Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), and AD patients and to evaluate relationships between NfL and CSF biomarkers and neuropsychological scores.

Materials and methods
We enrolled 110 patients (34 SCD, 53 MCI, and 23 AD), who underwent clinical and neuropsychological evaluation, APOE genotyping, and plasma NfL analysis. Ninety-one patients underwent at least one amyloid burden biomarker (CSF and/or amyloid PET); 86 patients also underwent CSF phosphorylated-tau (p-tau) and total-tau (t-tau) measurement. Patients were classified as A + if they presented at least one positive amyloid biomarker or A− if not.

Results
NfL levels were significantly increased in AD and MCI compared to SCD patients. These differences depend on A status, e.g., SCD A + had lower NfLs than MCI A + but comparable with MCI A−. Similarly, MCI A + had higher NfL levels than MCI A−, but comparable with AD. NfL levels correlated with p-tau in SCD, with all CSF biomarkers in MCI patients. No correlations were found in AD subgroup. In SCD, NfL levels were negatively correlated with memory test scores.

Conclusions

Plasma NfL levels might be a promising biomarker for neurodegeneration to discriminate cognitive decline due to AD from other conditions causing cognitive impairment in prodromal stages. Considering correlations with CSF p-tau and memory tests in SCD, NfL might be a useful peripheral biomarker also in preclinical phases of AD.
Open versus laparoscopic repair of inguinal hernia: an overview of systematic reviews of randomised controlled trials
Authors: Haladu Nafi’u , Alabi Adegoke , Brazzelli Miriam , Imamura Mari , Ahmed Irfan , Ramsay George , Scott Neil W. 
Published: March 2022

Abstract
Background
Inguinal hernia has a lifetime incidence of 27% in men and 3% in women. Surgery is the recommended treatment, but there is no consensus on the best method. Open repair is most popular, but there are concerns about the risk of chronic groin pain. Laparoscopic repair is increasingly accepted due to the lower risk of chronic pain, although its recurrence rate is still unclear. The aim of this overview is to compare the risk of recurrence and chronic groin pain in laparoscopic versus open repair for inguinal hernia.

Methods
We searched Ovid MEDLINE, EMBASE and the Cochrane Database of Systematic Reviews for systematic reviews and meta-analyses. Only reviews of randomised controlled trials (RCTs) in adults published in English were included. Conference proceedings and editorials were excluded. The quality of the systematic reviews was assessed using the AMSTAR 2 checklist. Two outcomes were considered: hernia recurrence and chronic pain.

Results
Twenty-one systematic reviews and meta-analyses were included. Laparoscopic repair was associated with a lower risk of chronic groin pain compared with open repair. In the four systematic reviews assessing any laparoscopic versus any open repairs, laparoscopic repair was associated with a statistically significant (range: 26–46%) reduction in the odds or risk of chronic pain. Most reviews showed no difference in recurrence rates between laparoscopic and open repairs, regardless of the types of repair considered or the types of hernia that were studied, but most reviews had wide confidence intervals and we cannot rule out clinically important effects favouring either type of repair.

Conclusion
Meta-analyses suggest that laparoscopic repairs have a lower incidence of chronic groin pain than open repair, but there is no evidence of differences in recurrence rates between laparoscopic and open repairs.
Physio- und sporttherapeutische Interventionen zur Behandlung eines Karpaltunnelsyndroms
Authors: Gräf Julia Katharina , Lüdtke Kerstin , Wollesen Bettina 
Published: March 2022

Zusammenfassung
Hintergrund
Die Behandlung des Karpaltunnelsyndroms (KTS) besteht in der Regel in einer operativen Dekompression des Nervs oder Schienung und einer zusätzlichen medikamentösen Therapie. Physio- und Sporttherapie können eine nichtinvasive und gleichzeitig nebenwirkungsarme Alternative darstellen.

Ziel
Die vorliegende Übersichtsarbeit fasst aktuelle Studien zur Wirksamkeit von physio- und sporttherapeutischen Interventionen für die Therapie des KTS systematisch zusammen und fokussiert auf die Reduktion der Symptome sowie als sekundäres Outcome auf die Verbesserung der Funktionalität der Hand.

Material und Methoden
Das systematische Review integriert randomisierte, kontrollierte Studien mit physio- oder sporttherapeutischen Interventionen, die in den elektronischen Datenbanken PubMed, CINAHL und Web of Science bis Februar 2021 publiziert wurden. Den Richtlinien von Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) und der Cochrane Collaboration folgend wurden eine systematische Suche der Literatur, eine Datenextraktion und eine Bewertung des „risk of bias“ anhand des Cochrane Risk of Bias Tool von zwei unabhängigen Reviewern durchgeführt.

Ergebnisse
Von 461 identifizierten Studien konnten n = 26 in die qualitative Analyse einbezogen werden. Das Biasrisiko über die einzelnen Studien ist als moderat bis gering einzustufen. Verzerrungspotenzial ergibt sich teilweise durch eine unzureichende Verblindung der Patient:innen und des Studienpersonals sowie durch eine selektive Berichterstattung der Studienergebnisse und der Durchführung. Die manuelle Therapie erwies sich im Vergleich zu einem operativen Eingriff als schneller und langfristig gleichermaßen zielführend in Bezug auf Schmerzreduktion und Funktionsverbesserung. Auch Mobilisationstechniken, Massagetechniken und das Kinesiotaping sowie Yoga als therapeutische Interventionen zeigten positive Effekte.

Schlussfolgerung
In der Therapie eines leichten bis mittelschweren KTS zeichnen sich physio- und sporttherapeutische Interventionen vor allem durch Erfolge bereits nach 2‑wöchiger Behandlung aus, zudem durch vergleichbare Erfolge wie nach operativem Eingriff und 3‑monatiger postoperativer Behandlung. Zudem sind Patient:innen keinen Operationsrisiken ausgesetzt. Das Review ist im International Prospective Register of Systematic Reviews (PROSPERO) mit der Nr. 42017073839 registriert.
Human resource labor dispatch model using an improved genetic algorithm
Authors: Feng Qi , Su Xingren , Li Qiang 
Published: March 2022

AbstractThe management and development of human resources (HR) have become one of the core contents of enterprise management. Enterprises pay more attention to the importance of information technology which results in the development of many labor dispatch enterprises. The rapid development and limited market share of labor dispatch enterprises lead to more fierce competition among the enterprises. With the rapid development of machine learning techniques, more enterprises begin to pay attention to managing the completion of various decision-making activities in operation with the help of computer information systems to save human costs. The labor dispatch model is a valuable addition to China's core contractual employment paradigms. Based on the improved genetic algorithm, this paper studies the human resource labor dispatch model which is used to optimize the number of people required by the dispatch project and optimize its labor cost. The HR recruitment model is used to calculate the number of people to be recruited for the dispatch project to meet the needs of the project and optimize its project dispatch scheme. The experimental results show that the benefit of dispatching through the artificial selection method (1127) is less than the result calculated by the HR dispatching plan model (1162), which proves the effectiveness of this model. The experimental results of the study depict the usefulness of the research.
Inequalities between torsional rigidity and principal eigenvalue of the p-Laplacian
Authors: Briani Luca , Buttazzo Giuseppe , Prinari Francesca 
Published: March 2022

AbstractWe consider the torsional rigidity and the principal eigenvalue related to the p-Laplace operator. The goal is to find upper and lower bounds to products of suitable powers of the quantities above in various classes of domains. The limit cases $$p=1$$

p
=
1

and $$p=\infty $$

p
=
∞

are also analyzed, which amount to consider the Cheeger constant of a domain and functionals involving the distance function from the boundary.
Gut-disc axis: A cause of intervertebral disc degeneration and low back pain?
Authors: Li Wentian , Lai Kaitao , Chopra Neha , Zheng Zhaomin , Das Abhirup , Diwan Ashish D. 
Published: March 2022

Abstract
Purpose
Low back pain (LBP), a widely prevalent and costly disease around the world, is mainly caused by intervertebral disc (IVD) degeneration (IDD). Although numerous factors may trigger this degenerative process, microbiome dysbiosis has recently been implicated as one of the likely causes. However, the exact relationship between the microbiome and IDD is not well understood. This review summarizes the potential mechanisms and discusses microbiome dysbiosis’s possible influence on IDD and LBP.

Methods
Prospective literature review.

Results
Alterations in microbiome composition and host responses to the microbiota causing pathological bone development and involution, led to the concept of gut-bone marrow axis and gut-bone axis. Moreover, the concept of the gut-disc axis was also proposed to explain the microbiome’s role in IDD and LBP. According to the existing evidence, the microbiome could be an important factor for inducing and aggravating IDD through changing or regulating the outside and inside microenvironment of the IVD. Three potential mechanisms by which the gut microbiota can induce IVD and cause LBP are: (1) translocation of the bacteria across the gut epithelial barrier and into the IVD, (2) regulation of the mucosal and systemic immune system, and (3) regulation of nutrient absorption and metabolites formation at the gut epithelium and its diffusion into the IVD. Furthermore, to investigate whether IVD is initiated by pathogenic bacteria and establish the correlation between the presence of certain microbial groups with the disease in question, microbiome diversity analysis based on16S rRNA data can be used to characterise stool/blood microbiota from IVD patients.

Conclusion
Future studies on microbiome, fungi and viruses in IDD is necessary to revolutionize our thinking about their possible role in the development of IVD diseases. Furthermore, we believe that inflammation inhibition and interruption of amplification of cascade reaction in IVD by targeting the gut and IVD microbiome is worthwhile for the treatment of IDD and LBP.

Level of Evidence I
Diagnostic: individual cross-sectional studies with the consistently applied reference standard and blinding.
Tryptophan modulation in individuals with attention deficit hyperactivity disorder: a systematic review
Authors: Dinu Larisa Maria , Phattharakulnij Nachaphol , Dommett Eleanor Jane 
Published: March 2022

AbstractThe serotonergic system is implicated in ADHD, but the impact of serotonin’s precursor molecule, tryptophan, on ADHD symptomology remains unclear. Systematic searches of randomised controlled trials with an experimental tryptophan intervention in children and adults with ADHD identified 14 studies measuring core and related symptoms of the condition. Risk of bias was assessed using the Cochrane Risk of Bias tool. The 14 studies all used acute tryptophan depletion procedures, and most did not investigate core ADHD symptoms (inattention, impulsivity, hyperactivity) as primary outcome measures. Only two studies examined attention and revealed mixed effects of tryptophan. Similar effects were found for impulsivity in a small number of studies. No studies investigated hyperactivity. Most studies focused on reactive aggression, but samples were heterogenous and small, rendering potential meta-analyses inconclusive or misleading. However, the narrative analysis indicates tryptophan interventions may impact reactive aggression. More research is needed on the effect of tryptophan modulation on core ADHD symptoms, especially in adults, using more diverse samples to determine potential as an intervention. From current data, tryptophan modulation appears to alter aggressive behaviour in ADHD; however, the available studies were insufficient for the planned meta-analysis.
Effects of local climate and habitat heterogeneity on breeding-bird assemblages of semi-natural grasslands
Authors: Brüggeshemke Jonas , Drung Marco , Löffler Franz , Fartmann Thomas 
Published: March 2022

AbstractThe intensification of agricultural land-use, abandonment and afforestation have caused severe loss and degradation of nutrient-poor, semi-natural grasslands across Europe. Calcareous grasslands have an outstanding value for nature conservation due to their highly diverse flora and fauna, including birds. However, knowledge of environmental factors driving the composition of bird communities in calcareous grasslands is still scarce. The aim of our study was to compare the breeding-bird assemblages of calcareous grasslands and the second most common semi-natural grassland type in the study area (Diemel Valley, Central Germany), mesic grasslands, along an elevation (climate) gradient. For each grassland type, we randomly selected 27 square-shaped plots with a size of 5 ha each and a cover of the focal grassland type of at least 50% within the plot. Our study revealed that both the number and density of threatened species of breeding birds were higher in plots of calcareous grasslands than in those of mesic grasslands. Based on multivariable generalised linear mixed-effects models, the most important predictors of overall species richness and density of breeding birds in plots of calcareous grasslands were the area of juniper-rich calcareous grassland and Shannon habitat diversity. By contrast, the number and density of threatened species were in both grassland types mainly driven by breeding-season temperature. Heterogeneous, juniper-rich calcareous grasslands seem to be a key habitat for bird assemblages with high species richness and density. These grasslands usually consisted of small-scale habitat mosaics providing suitable nesting sites and foraging grounds in close proximity. By contrast, mesic grasslands had rather homogeneous swards and shrubs or trees were normally restricted to the edges of the grassland patches. Based on our study, increasing habitat heterogeneity at the landscape scale and within grasslands is the key to enhancing species richness and density of breeding birds.
Relationship of indoor solid fuel use for cooking with blood pressure and hypertension among the elderly in China
Authors: Yu Qiutong , Zuo Genyong 
Published: March 2022

AbstractIndoor air pollution caused by solid fuel use for cooking affects 2.5 billion people worldwide and may elevate blood pressure (BP) and increase the burden of hypertension. Although the elderly are the most at risk of an elevated BP and hypertension, few studies have evaluated the effect of indoor solid fuel use for cooking on BP in persons over the age of 65. Therefore, in this study, we randomly selected 8067 elderly people over 65 years of age from the 2018 Chinese Longitudinal Healthy Longevity Survey to determine the impact of indoor solid fuel use on BP/hypertension. The results showed that, compared with those who cooked with clean fuel, those who cooked with solid fuel had a 1.87 mmHg higher systolic blood pressure, a 0.09 mmHg higher diastolic blood pressure, a 0.97 mmHg higher pulse pressure, and a 1.22 mmHg higher mean arterial pressure. However, we did not find any association between indoor solid fuel use and hypertension. We further observed that northern China residents, women, people aged over 90 years, hypertensive and heart patients, and those with natural ventilation in the kitchen that used indoor solid fuel experienced a greater BP impact. Replacing solid fuel with clean fuel may be an important way to lower BP. Regarding this, priority access to clean fuel should be given to the susceptible population, including the elderly aged ≥ 75 years, northern China residents, women, and hypertensive and heart patients.
Paramagnetic contrast medium in high-level athletes with lower limb muscle injuries: can it make the return to sport safer reducing the recurrence rate?
Authors: Calvi Marco , Curti Marco , Mazzoni Stefano , Genesio Lucio , Tavana Rodolfo , Callegari Leonardo , Genovese Eugenio Annibale 
Published: March 2022

Abstract
Purpose
The aim is to investigate whether contrast medium can improve accuracy in the assessment of healing muscle injury in high-level professional athletes.

Materials and methods
Our series is a retrospective study including the records of 22 players (mean age 28 ± 5 SD) with lower limbs muscle injuries type 3a (Mueller-Wohlfarth). All athletes received two MRIs: the day after the injury and before resuming heavy effort activities. Contrast medium uptake was measured in the second MRI by comparing the mean enhancement at the lesion site (ME) with that of the healthy contralateral muscle (HM). The result is a percentage referred to as muscular contrast index (MC index). The difference between the mean MC index value between athletes with and without re-injury was assessed with both the Mann–Whitney and the Kruskal–Wallis test.

Results
Twenty-nine muscle injuries matched the inclusion criteria. The mean MC index values, adjusted for the variable of time elapsed between the last contrast examination and return to the field, were significantly different in the two study groups (p < .001).

Conclusion
The contrast medium in the follow-up of muscle injuries may be useful in determining the degree of scar stability in a healing injury. Injuries with a high MC index were found to be ‘unstable’, with a higher rate of recurrence than those with a low MC index. Resumption of competitive activity after achieving not only clinical resolution but also a satisfactory MC index value may increase the safety of return to the field and reduce the recurrence rate.