bluuebunny/crossref_metadata_2025_split huggingface dataset:
The potential distributions of African Azolla species and their implications for African wetland ecosystems for the future
Authors: Karichu Mwihaki J. , Ngarega Boniface K. , Onjalalaina Guy E. , Kamau Peris , Sessa Emily B. 
Published: August 2022

AbstractClimate change is predicted to affect species in aquatic ecosystems. In Africa, factors that may influence the responses of aquatic species are poorly studied and challenging to predict. In this study, we examined the potential distribution of three aquatic fern species in the genus Azolla in Africa under projected climate change scenarios. MaxEnt was used to create ecological niche models of the three species using occurrence data and environmental variables. All models had satisfactory AUC and TSS values, indicating high prediction precision (AUC and TSS > 0.801). Results showed that elevation and precipitation were the most important variables limiting the species' expansion in the future. In addition, we observed significant variations in the climatic niches of the three species and their distinct climatically appropriate regions. The current potential distribution ranges for the species varied between 2,328,726 km2 and 4,026,363 km2. According to the model predictions for the current period, the potential range of Azolla species extended outside the known and recorded locations; however, under future climate conditions, the species were projected to lose between 8.1% and 48% of their suitable habitats due to climate change. Our findings can be used to develop sustainable conservation measures for aquatic species and raise awareness about the effects of climate change.
The Contribution of CIRCC Partners to the Birth and Growth of CO2 Chemistry
Authors: Aresta Michele 
Published: August 2022

AbstractThis paper tells the recent history of CO2 chemistry through the contributions from members of CIRCC to its birth and growth. Starting with the first transition metal complex bearing CO2 as a ligand synthesized in 1975 by the Aresta Group in Bari, the mode of bonding and the reactivity of coordinated CO2 are discussed. The early applications in chemo‐thermal, electrolytic, and biotechnological processes, and the use of SC‐CO2 as solvent and reagent are fields in which CIRCC partners have made pioneering contributions and continue to provide essential inputs. The paper is closed by highlighting key issues and challenges at stake, from capture to large‐scale conversion, investment infrastructure, progressive policies and standardized regulations needed to advocate carbon recycling as a pillar of future innovation in energy and chemical industries. CIRCC has been the nest of modern CO2 chemistry and the place where CO2 has always been considered a “resource” rather than a “waste”.
Status quo of pain‐related patient‐reported outcomes and perioperative pain management in 10,415 patients from 10 countries: Analysis of registry data
Authors:   PAIN OUT Research Group Jena,   Chinese PAIN OUT network,   Dutch PAIN OUT network,   Méxican PAIN OUT network,   Serbian PAIN OUT network,   Spanish PAIN OUT network,   French PAIN OUT network,   Italian PAIN OUT network,   Swiss PAIN OUT network,   Irish PAIN OUT network,   Belgian PAIN OUT network, Zaslansky Ruth 
Published: August 2022

AbstractBackgroundPostoperative pain is common at the global level, despite considerable attempts for improvement, reflecting the complexity of offering effective pain relief. In this study, clinicians from Mexico, China, and eight European countries evaluated perioperative pain practices and patient‐reported outcomes (PROs) in their hospitals as a basis for carrying out quality improvement (QI) projects in each country.MethodsPAIN OUT, an international perioperative pain registry, provided standardized methodology for assessing management and multi‐dimensional PROs on the first postoperative day, in patients undergoing orthopaedic, general surgery, obstetric & gynaecology or urological procedures.ResultsBetween 2017 and 2019, data obtained from 10,415 adult patients in 105 wards, qualified for analysis. At the ward level: 50% (median) of patients reported worst pain intensities ≥7/10 NRS, 25% spent ≥50% of the time in severe pain and 20–34% reported severe ratings for pain‐related functional and emotional interference. Demographic variables, country and surgical discipline explained a small proportion of the variation in the PROs, leaving about 88% unexplained. Most treatment processes varied considerably between wards. Ward effects accounted for about 7% and 32% of variation in PROs and treatment processes, respectively.ConclusionsThis comprehensive evaluation demonstrates that many patients in this international cohort reported poor pain‐related PROs on the first postoperative day. PROs and treatments varied greatly. Most of the variance of the PROs could not be explained. The findings served as a basis for devising and implementing QI programmes in participating hospitals.SignificanceIn preparation for quality improvement projects, we comprehensively evaluated pain‐related patient‐reported outcomes (PROs) and treatment practices of 10,415 adult patients spanning 10 countries. PROs were generally poor. Demographics, country and surgical discipline explained a small proportion of variation for the PROs, about 88% remained unexplained. Treatment practices varied considerably between wards. Ward effects accounted for about 7% and 32% of variation in PROs and treatment processes, respectively. Future studies will aim to identify treatments which are associated with improved outcomes.
Assessing the efficiency implications of renewable fuel policy design in the United States
Authors: Zhong Jia , Khanna Madhu 
Published: August 2022

AbstractObligated parties have chosen to comply with the Renewable Fuel Standard (RFS) by increasing the blending of biomass‐based biodiesel beyond originally targeted levels rather than increasing blending/consumption of ethanol to targeted levels that would have required pricing higher blends of ethanol (E85) at or below an energy‐equivalent level to E10. This paper develops a welfare‐economic framework to analyze the extent to which the nested design and the accompanying cellulosic waiver credit and biodiesel tax credit contributed to a compliance strategy by blenders that favored blending of biodiesel instead of inducing consumption of E85, and its implications for social welfare.
In vitro and in vivo local tolerability of a synergistic anti‐tuberculosis drug combination intended for pulmonary delivery
Authors: Ravon Faustine , Menchi Elena , Lambot Coralie , Al Kattar Sahar , Chraibi Selma , Remmelink Myriam , Fontaine Véronique , Wauthoz Nathalie 
Published: August 2022

AbstractA drug combination, vancomycin (VAN) plus tetrahydrolipstatin (THL), has demonstrated an effective synergistic action in vitro against Mycobacterium tuberculosis (Mtb). The poor oral bioavailability of VAN and THL and the predominant tropism of Mtb infection to the lungs make their pulmonary administration very attractive. To evaluate their local tolerability, bronchial cells, alveolar cells and monocytes were exposed to concentrations around and above their minimal inhibitory concentration (MIC). The VAN had no inhibitory activity on the tested human cell lines, even at a concentration 125 times higher than its MIC, whereas the THL, alone or in combination with VAN, presented a cytostatic action. Monolayer epithelium showed no significant irreversible damage at concentrations up to 100 times the combination MIC. BALB/cAnNRj mice exposed to concentration of 50 times the combination MIC delivered endotracheally 3 times a week for 3 weeks showed no clinical signs or significant weight loss. The increase of proinflammatory biomarkers (i.e., IL‐1, IL‐6, TNF‐α and proportion of inflammatory cells) and cytotoxicity in bronchoalveolar lavage fluid (BALF) were non‐significant. Lung histopathology did not show significant tissue damage. The VAN/THL combination at doses up to 50 times the combination MIC is found to be thus well tolerated by pulmonary route. This study is a promising result and encouraging further investigations of pulmonary administration of VAN/THL combination as dry powder for anti‐tuberculosis treatment.
External fields in conceptual density functional theory
Authors: Geerlings Paul , De Proft Frank 
Published: August 2022

AbstractThe necessity of the recent incorporation of new external variables in the context of conceptual DFT (CDFT) is discussed based on the ever‐increasing portfolio of experimental reaction conditions in the endeavor of experimentalists to synthesize new molecules with unprecedented properties. Electric and magnetic fields (ε and B), mechanical forces (F), and confinement are proposed as valuable new variables, extending conventional CDFT and its associated response functions. A finite field approach is used to calculate the evolution of both global and local descriptors in a selected series of atomic and molecular applications, and from it derive new response function involving, with one exception, the first derivative to the field considered. The electric field results, displaying, for example, a case of a field‐induced enantioselectivity in the Fukui function, may be instrumental in the recent upsurge of chemistry in oriented external electric fields. The study of atomic electronegativity and hardness in magnetic fields displays a piecewise behavior, associated to configurational jumps upon increasing field strength and reveals an overall compression of their ranges for stronger fields, which may be guiding upon investigating chemistry in extremely high fields like in white dwarfs. The evolution of the electronegativity and hardness of diatomics under mechanical force can elegantly be traced back to differences in their equilibrium distance in the neutral, cationic, and anionic state. The well‐known reduction of the polarizability under confinement can be seen as a fore‐runner of the increasing hardness of atoms under pressure, presently under investigation. Periodicity showing up in a spontaneous way in the variety of properties is a leitmotiv in this study, as well as the interconnections/analogies between the different response functions.
Recent weakening of the relationship between El Niño–Southern Oscillation and western North Pacific tropical cyclone season onset date
Authors: Gao Jun , Zhao Haikun , Klotzbach Philip J. , Shi Chunhua , Ma Zhanhong 
Published: August 2022

AbstractThis study investigates the climate drivers of western North Pacific (WNP) tropical cyclone season onset date (TCSOD). We find that the interannual relationship between WNP TCSOD and El Niño–Southern Oscillation (ENSO) varies considerably on interdecadal time scales. The association between TCSOD and ENSO, as measured by the Niño3.4 index, is significant during the first subperiod from 1979 to 1998 (r = .51) but becomes insignificant (r = .01) during the second subperiod from 1999 to 2019. This relationship degradation is mainly due to shifting ENSO conditions with more frequent occurrences of tropical central Pacific ENSO events since the late 1990s. Tropical eastern Pacific ENSO events cause changes in the low‐level large‐scale circulation over the tropical western WNP, where early season WNP TC genesis typically occurs, via a Gill‐type Rossby wave response. Tropical central Pacific ENSO events have a limited impact over this region. These relationships are confirmed by a stable and strong association between tropical eastern Pacific ENSO and TCSOD for the whole period (r = .63) and for the two subperiods (r = .72/r = .56), while the correlation between central Pacific ENSO events and TCSOD is weak for the whole period (r = −.01) and for the two subperiods (r = −.03/r = −.13). We further find that the Pacific meridional mode is a robust indicator of TCSOD over the WNP regardless of shifting ENSO conditions. Results of this study may provide useful information for decadal climate prediction of WNP TCSOD.
The Creative Industries Entrepreneur: An Analysis of Lived Experience
Authors: Patten Tena , Stephens Simon 
Published: August 2022

ABSTRACTExpanding our understanding of the lived experience of individuals who use their creativity to realize entrepreneurial opportunity is the primary aim of this paper. Interpretative Phenomenological Analysis is used, based on two interviews of one‐hour duration, with eight participants. The key contribution of this research is the recognition of the Creative Industries Entrepreneur. A Creative Industries Entrepreneur is an individual who occupies a space between traditional entrepreneurship theory and established creativity models. The main driving force in opportunity formation for a Creative Industries Entrepreneur is their creative impulse. This pushes them to achieve a personhood, which can reconcile intrinsic impulses with external market forces and social imperatives.
Variation in seagrass meadow respiration measured by aquatic eddy covariance
Authors: Juska Ieva , Berg Peter 
Published: August 2022

AbstractAccurate daily metabolic estimates of respiration, gross primary production, and net ecosystem metabolism are necessary to assess ecosystem health and blue carbon contributions of vegetated coastal ecosystems. Using our database of 2115 hourly benthic oxygen (O2) fluxes measured by aquatic eddy covariance, we examine how respiration for a Zostera marina seagrass meadow varies through night and day, and how this affects commonly performed metabolic estimates. Respiration decreased linearly by 29% through the night and a corresponding linear increase in daytime respiration coupled with production described by a standard photosynthesis–irradiance curve accurately predicted measured daytime O2 fluxes. Many studies have questioned the widely used assumption in metabolic estimates that nighttime and daytime respiration are constant and equal. However, if respiration can be approximated as we found here by linear relationships, standard means for calculating daily metabolic numbers remain valid if estimates are based on full 24‐h records of flux data.
Surface Nucleation of Dispersed Droplets in Double Semicrystalline Immiscible Blends with Different Matrices
Authors: Wang Wei , Buzzi Simona , Fenni Seif Eddine , Carmeli Enrico , Wang Bao , Liu Guoming , Müller Alejandro J. , Cavallo Dario 
Published: August 2022

AbstractWhen a minor semicrystalline phase is dispersed in an immiscible blend with another polymer in the form of isolated droplets, its crystallization behavior is dominated by nucleation. In particular, nucleation can occur in the bulk volume of the phase (homogeneous nucleation), at the surface of possible nucleating foreign impurities, or at the interface with the matrix polymer. Dispersed poly(butene‐1) (PB) and polycaprolactone (PCL) droplet phases are employed in various matrices (isotactic polypropylene (iPP), high density polyethylene (HDPE), poly(vinylidene fluoride) (PVDF) and poly(butylene succinate) (PBS)). The effect of matrix self‐nucleation on the crystallization of the dispersed droplet phase is then probed. It is shown for all the investigated polymer blends that increasing the matrix crystallization temperature (Tc) via self‐nucleation favors droplet nucleation at the interface, leading to a corresponding increase in the droplets'; Tc. Interestingly, distinct nucleation effects are observed when different polymer matrices are compared. The highest nucleating efficiency is displayed by the polymer pairs, which are known to exhibit epitaxial crystallization from previous literature, namely PB/iPP and PCL/HDPE. The order of nucleation efficiency of the other matrices is thought to be linked with the extent of crystallographic matching between the substrate and nucleating crystals.
Conservative Iron Chelation for Neuroferritinopathy
Authors: Marchand Felix , Moreau Caroline , Kuchcinski Gregory , Huin Vincent , Defebvre Luc , Devos David 
Published: August 2022

AbstractBackgroundNeuroferritinopathy is a rare inherited neurodegenerative disease with brain iron accumulation characterized by brain iron overload resulting in progressive movement disorders. No treatment is currently available.ObjectiveWe assessed conservative iron chelation with deferiprone at 30 mg/kg/day on the disease progression with controlled periods of discontinuation.MethodsFour patients with confirmed molecular diagnosis of neuroferritinopathy were given deferiprone at different stages of disease progression and with clinical and biological monitoring to control benefit and risk.ResultsThe four patients showed slight to high improvement. In one case, we managed to stabilize disease progression for more than 11 years. In another case, we were able to reverse symptoms after a few months of treatment. The earliest the treatment was started, the most efficient it was on disease progression.ConclusionsConservative iron chelation should be further assessed in neuroferritinopathy. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
JAK2 rs10974944 is associated with both V617F‐positive and negative myeloproliferative neoplasms in a Vietnamese population: A potential genetic marker
Authors: Ngoc Nguyen Thy , Hau Bui Bich , Vuong Nguyen Ba , Xuan Nguyen Thi 
Published: August 2022

AbstractThe JAK2 gene encodes for a non‐receptor tyrosine kinase that plays a key role in the JAK/STAT signaling transfer pathway. Genetic polymorphisms of this gene have been indicated to be associated with myeloproliferative neoplasm‐associated thrombosis in recent studies. This research aimed to evaluate the association between the variant rs10974944 and different types of Myeloproliferative neoplasms disorders in the Vietnamese population. DNA samples were obtained from 172 essential thrombocythemia patients, 14 primary myelofibrosis patients, 76 polycythemia vera patients, and 192 healthy controls. The JAK2 rs10974944 and V617F genotypes were identified by the polymerase chain reaction‐restriction fragment length polymorphism genotyping and Sanger sequencing methods. Results showed that there was a strong association between rs10974944 and Myeloproliferative neoplasms phenotype (p < .0001) and the most significant association was observed in the recessive model of the mutant allele (G). The G allele carriers had a 1.74, 2.86, and 3.03 higher risk of getting essential thrombocythemia, primary myelofibrosis, and polycythemia vera, respectively. Interestingly, this effect of rs10974944 seemed to be independent of the JAK2 V617F genotype. The distribution of rs10974944 genotypes were significantly different between V617F‐positive and negative groups (p = .008). Moreover, the GG genotype of rs10974944 was observed to be associated with the risk of getting Myeloproliferative neoplasms both in JAK2 V617F‐positive group, and for the first time in JAK2 V617F‐negative patients. A systematic meta‐analysis in different populations strengthened the evidence regarding the correlation between rs10974944 and myeloproliferative neoplasm disorders. To sum up, our results suggested that rs10974944 can be used as a predisposition screening marker for predicting Myeloproliferative neoplasms susceptibility.
Usefulness of immunohistochemical diagnosis for squamous cell carcinoma of the dorsum of the tongue: A case report
Authors: Abe Ayaka , Kono Tatsuyuki , Wakamatsu Rina , Kamate Mie , Kawano Kenji 
Published: August 2022

AbstractBackgroundSquamous cell carcinoma (SCC) of the dorsum of the tongue frequently presents as an exophytic mass mimicking benign lesions.Case PresentationWe report a case of a 69‐year‐old woman with an exophytic lesion on the dorsum of the tongue. She underwent biopsy twice prior to surgical excision. The biopsy specimens revealed epithelial hyperplasia, and the pathological diagnosis from the surgical material was well‐differentiated SCC. Immunohistochemical findings of cytokeratin 13 (CK13), CK17, Ki‐67, and p53 showed the pre‐neoplastic nature of the hyperplastic epithelia in the biopsy specimens.ConclusionImmunohistochemical staining is useful for the diagnosis of exophytic lesions of the dorsum of the tongue.
Prenatally diagnosed coronary artery abnormalities in hypoplastic left heart syndrome are associated with a higher probability of heart transplantation
Authors: Rueda‐de‐Leon Elena , Killen Stacy A. S. , Soslow Jonathan H. , McHugh M. Kelly , Fuchs Sarah R. , Kavanaugh‐McHugh Ann 
Published: August 2022

AbstractObjectiveCoronary artery abnormalities (CA) occur in patients with hypoplastic left heart syndrome (HLHS) and may be associated with higher mortality and heart transplantation (HT). We aimed to determine whether fetuses with HLHS and prenatal CA have a higher risk of death or HT.MethodsWe performed a retrospective review of fetal echocardiograms with HLHS from 2011 to 2018. We excluded fetuses with ventricular septal defects, elective termination, death in utero, planned postnatal non‐intervention, or absent follow‐up data. Presence or absence of CA was determined by review of serial fetal echocardiograms. Survival analysis was used to evaluate the relationship between prenatal CA and death or HT.ResultsOf 86 patients with fetal HLHS, 11 had prenatal diagnosis of CA. Of these, six required HT and five died (one after undergoing HT); only one remains alive without HT. Of those without prenatal CA (n = 75), 25 died and 7 underwent HT. Patients with prenatal diagnosis of HLHS and CA had a significantly increased likelihood of death or HT (p‐value <0.05).ConclusionPrenatal diagnosis of CA in our cohort of patients with HLHS was associated with increased risk of death or HT. These data have significance for prenatal counseling and postnatal management.
Impact of connected health interventions on psychological wellbeing and quality of life in patients with cancer: A systematic review and meta‐analysis
Authors: Gitonga Isaiah , Desmond Deirdre , Duda Natalia , Maguire Rebecca 
Published: August 2022

AbstractObjectiveConnected health technologies have the potential to improve access to cancer care and support and reduce costs. We aimed to assess the impacts of interventions delivered using connected health technologies on psychological and quality of life (QoL) outcomes in people living with and beyond cancer.MethodsPUBMED, PsycINFO, Web of Science, and EMBASE were searched using terms relating to (i) cancer, (ii) connected health, and (iii) QoL/psychological wellbeing. Studies were included if they evaluated interventions using connected health technologies and assessed psychological and/or QoL outcomes for adults at any stage of cancer treatment or survivorship.ResultsThirty‐seven studies met the inclusion criteria with a total of 8956 participants. Connected health technologies included web‐based applications (n = 24), smart applications (n = 12), and wearable devices (n = 1). Studies were heterogeneous in terms of intervention components. We identified five clusters: (i) Psychosocial support and rehabilitation, (ii) psychoeducation and information support, (iii) symptom monitoring, reporting and self‐management, (iv) peer and social support, and (v) health coaching and physical activity training. Due to heterogeneity of outcome measures, the meta‐analysis included only seven RCTs; pooled mean estimates showed connected health interventions were moderately effective in reducing symptoms of depression (SMD: −0.226, 95% CI −0.303/−0.149) and anxiety (SMD: −0.188, 95% CI: 0.279/−0.0963) compared with usual care.ConclusionWhile the considerable heterogeneity observed highlights the need for more rigorous studies to improve reproducibility and efficiency, results suggest that connected health interventions have the potential to improve psychological wellbeing and QoL outcomes in people living with and beyond cancer.