bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comprehensive Review of Soluble Epoxide Hyådrolase Inhibitors Evaluating
their Structure-Activity Relationship
Authors: Tabatabai Sayyed Abbas , Nazari Maryam , Rezaee Elham 
Published: June 2022

Abstract:
Soluble epoxide hydrolase is a class of α/β-fold hydrolase enzymes that exist in numerous organs and tissues, including the liver, kidney, brain, and vasculature. This homodimer enzyme is responsible for degrading epoxyeicosatrienoic acids to the less active vicinal diols, dihydroxyeicosatrienoic acids through adding a molecule of water to an epoxide in the cytochrome P450 pathway. Soluble epoxide hydrolase was firstly assayed and characterized by Hammock and colleagues about 40 years ago. Upholding high epoxyeicosatrienoic acid blood levels by inhibiting soluble epoxide hydrolase has been proposed as a hopeful strategy to treat renal and cardiovascular diseases, inflammation, and pain. Therefore, developing novel soluble epoxide hydrolase inhibitors has been an attractive research topic for many years. Regarding this issue, some carbamates, heterocycles, amides, and ureas have been proposed; however, rapid metabolism, low solubility, high melting point, and weak pharmacokinetic characteristics are challenges posed to the researchers.
In this review, we have focused on the role of the soluble epoxide hydrolase in the metabolic pathway of arachidonic acid, and categorized most representative soluble epoxide hydrolase inhibitors into two main classes of synthetic and natural compounds. The structures have been evaluated and an exemplary structure-activity relationship has been provided for further development of potent inhibitors at the end. According to our findings, urea-based inhibitors were preferred to the amide-based scaffolds due to the better fitting into the active site. An aromatic linker is a suitable bridge to connect primary and secondary pharmacophores compared with aliphatic linkers.
Celebrating a Century of Insulin Discovery: A Critical Appraisal of the Emerging Alternative Insulin Delivery Systems
Authors: Sibiya Ntethelelo , Mbatha Bonisiwe , Ngubane Phikelelani , Khathi Andile 
Published: June 2022

Abstract:Since the discovery of insulin, continuous developments of this peptide have led to better management of diabetes mellitus, thus leading to a decrease in diabetes-related mortality. Despite these developments, we have seen an increase in diabetes cases, which has further necessitated more innovative methods for diabetes management. The subcutaneous administration of insulin remains the mainstay therapy for type 1 diabetes mellitus. However, despite the availability of insulin analogues with improved pharmacokinetics, challenges with conventional administration exist. The challenges associated with insulin injections include hypoglycaemic episodes, needle phobia, and injection-site inflammation, which all have been reported to reduce patient compliance. Ongoing research on diabetes management strives to develop therapies that provide improved glycaemic control with minimal side effects. In part, for these reasons, we have seen an increase in the search and development of alternative insulin delivery systems that are envisaged to circumvent the shortfalls associated with the conventional administration route. Several alternative drug delivery systems, such as oral, pulmonary, buccal, nasal, and transdermal, have been explored in the last century. These efforts have not been without victory, as we have seen the emergence of pulmonary (Exubera and Afrezza) and buccal insulin delivery systems licenced for therapeutic use. Despite the success seen in these two systems, their marketability and popularity have been severely compromised due to reported safety concerns. Although oral insulin delivery has always shown promise in the past decades; however, it was only limited to preclinical trials. The main challenge associated with this delivery route is poor bioavailability, which necessitates high insulin concentration to be administered. Due to recent developments, oral insulin has reached phase 3 clinical trials. It is believed that patients would prefer oral insulin as their preference is often observed for oral antidiabetics over injected ones. In the last decade, transdermal insulin has also gained interest, where delivery of insulin with a concomitant reduction in blood glucose concentration has been demonstrated in vivo. However, at present, there are no clinical studies that have reported the efficacy of transdermal insulin administration. With technological advancement, there is a potential to develop yet another insulin delivery system that would likely enter the markets. As these novel delivery systems have been found to be effective, emerging competing products should be welcome and appreciated.
Promising Essential Oils/Plant Extracts in the Prevention and Treatment of Dandruff Pathogenesis
Authors: Kumari KM Uma , Yadav Narayan Prasad , Luqman Suaib 
Published: June 2022

Background:Dandruff is a scalp malady affecting predominantly the male populace. Topical agents and synthetic drugs used for dandruff treatment have specific side effects including burning at the application site, depression, dizziness, headache, itching or skin rash, nausea, stomach pain, vision change, vomiting, discoloration of hair, dryness or oiliness of the scalp and increased loss of hair. Thus, essential oils and extracts from plants could be valuable in the treatment and prevention of dandruff.Aim & Objective:This review aims to highlight current findings in dandruff occurrence, its etiology, promising plant essential oils/extracts, and novel treatment strategies. The main emphasis has been given on the anti-dandruff effect of essential oils and plant extracts to disrupt microbial growth. The proposed mechanism (s) of action, novel approaches used to perk up its biopharmaceutical properties, and topical application have been discussed.Results:The literature survey was done, bibliographic sources and research papers were retrieved from different search engines and databases, including SciFinder, PubMed, NCBI, Scopus, and Google Scholar. The selection of papers was accomplished based on exclusion and inclusion criteria. The scalp of diverse populations revealed an association of dandruff with microbial symbiosis, including Staphylococcus, Propionibacterium, Malassezia, and Candida as the pathogens responsible for the cause of dandruff. Topical antifungals are considered as the first line of treatment for dandruff including azoles, with clotrimazole (1%), ketoconazole (2%), and miconazole (2%). Other commonly used therapies integrate benzoyl peroxide, coal tar, glycerin, zinc pyrithione, lithium succinate/gluconate, salicylic acid, selenium disulfide/sulfide, sodium sulfacetamide, etc. However, these medicaments and chemicals are known to cause specific side effects. Alternative therapies, including tea tree oil, thyme, Aloe vera, Mentha have been reported to demonstrate anti-dandruff activity by disrupting the microbial growth associated with dandruff formation.Conclusion:Overall, this review explains the occurrence of dandruff, its etiology, and the potential applicability of promising plant essential oils/extracts, and their novel treatment strategies. Further studies based on pre-clinical and clinical research are essential before making any conclusion about its efficacy in humans.
Comparative Analysis of Macroeconomic Indicators of the EU and the USA
Authors: Kuzmina V. M. , Parkhomchuk M. A. 
Published: June 2022

Relevance. At the beginning of the second decade of the XXI century. economic relations between the United States and the European Union continue to largely determine the development trends of the global economy and the world financial system. The stable dynamics of the transatlantic flows of goods, services and capital reflects the traditional proximity of the models of economic development of the United States and Western Europe, the stability of the existing ties, and the high effective demand of both regions for modern goods and services.The purpose is to carry out a comparative analysis of the macroeconomic indicators of the development of the EU countries and the USA.Objectives: consider the dynamics of the main macroeconomic indicators of the EU and the US from 2015 to 2020; to study and visualize the dynamics of GDP growth, GDP in PPP per capita, inflation in the EU member states for 2016–2020; investigate the dynamics of the total US government debt for 2015-2020.Methods. The method of statistical analysis of data from official government websites (European Parliament) and world agencies - Organization for Economic Cooperation and Development (OECD), Global-finances. The method of comparative analysis was used to compare real GDP, nominal GDP, GDP per capita, dynamics of changes in GDP EU countries and the USA in relation to previous years.Results. If we compare the development of the EU and the United States in terms of the main macroeconomic indicators, we can conclude that the countries have experienced periods of recession and stagnation in economic development to the same extent, including those associated with a lockdown and economic crises against the backdrop of a pandemic. However, in 2020, the countries showed a positive trend towards a reduction in negative GDP, including GDP in PPP per capita. The situation is more complicated in the United States, in terms of the size of the national debt.Conclusions. In modern conditions, the United States and the EU are still not only the main economic partners, but also the main competitors at the global level. The United States plays a leading role in international economic relations, but the United States has the largest trade deficit with China and the EU countries, therefore, in recent years, the idea of creating a free trade zone between the United States and the EU has been most actively supported (among business structures).
State Policy in the Sphere of Science and Knowledge-Intensive Production
Authors: Shmanev S. V. 
Published: June 2022

Relevance. Modern Russia is a succession of transformations of the national economy. The reforms carried out in the country affect the issues of social, scientific, scientific-technical (including the modernization of higher education), and general economic nature.The key mechanism for transforming Russia's economy is national projects, based on a series of documents developed and adopted by the government between 2002 and 2011. All ongoing transformations are based primarily on the development of human capital; systems related to education, health care; transformation of infrastructure; modernization of industry and public administration. The success of such transformations can be ensured by the state policy aimed at increasing the competitive advantages of the Russian economy in the field, science, and digitalization of the economy.Purpose. To analyze the current state of the Russian economy under the conditions of digital transformation and give recommendations for improving the mechanisms of macroeconomic regulation of the accelerated development of the Russian economy based on proactive industrial policy.Objectives. To substantiate the conceptual directions of the breakthrough development of industry in the Russian Federation in the strategic perspective, as the basis for sustainable socio-economic development of the country in the context of digitalization.Methodology. The study used methods of comparative analysis, economic-statistical and methods of expert evaluations.Results. The industrial complex, based on advanced technologies, is not only an indicator of the pace and efficiency of knowledge-intensive production, stabilizer of socio-economic processes but also serves as a guarantor of the national sovereignty of the country.Conclusions. The state socio-economic policy aimed at the introduction of advanced technologies affects not only the high-tech sector of the economy but also traditional industries. This policy will make it possible to transform the institutions of economic development and modernize existing business models, as well as to create conditions for improving the ongoing industrial policy.
Strategies for Implementing Occupational eMental Health Interventions: Scoping Review
Authors: Bernard Renaldo M , Toppo Claudia , Raggi Alberto , de Mul Marleen , de Miquel Carlota , Pugliese Maria Teresa , van der Feltz-Cornelis Christina M , Ortiz-Tallo Ana , Salvador-Carulla Luis , Lukersmith Sue , Hakkaart-van Roijen Leona , Merecz-Kot Dorota , Staszewska Kaja , Sabariego Carla 
Published: June 2022

Background
The implementation of eMental health interventions, especially in the workplace, is a complex process. Therefore, learning from existing implementation strategies is imperative to ensure improvements in the adoption, development, and scalability of occupational eMental health (OeMH) interventions. However, the implementation strategies used for these interventions are often undocumented or inadequately reported and have not been systematically gathered across implementations in a way that can serve as a much-needed guide for researchers.

Objective
The objective of this scoping review was to identify implementation strategies relevant to the uptake of OeMH interventions that target employees and detail the associated barriers and facilitation measures.

Methods
A scoping review was conducted. The descriptive synthesis was guided by the RE-AIM (reach, effectiveness, adoption, implementation, and maintenance) framework and the Consolidated Framework for Implementation Research.

Results
A total of 31 of 32,916 (0.09%) publications reporting the use of the web-, smartphone-, telephone-, and email-based OeMH interventions were included. In all, 98 implementation strategies, 114 barriers, and 131 facilitators were identified. The synthesis of barriers and facilitators produced 19 facilitation measures that provide initial recommendations for improving the implementation of OeMH interventions.

Conclusions
This scoping review represents one of the first steps in a research agenda aimed at improving the implementation of OeMH interventions by systematically selecting, shaping, evaluating, and reporting implementation strategies. There is a dire need for improved reporting of implementation strategies and combining common implementation frameworks with more technology-centric implementation frameworks to fully capture the complexities of eHealth implementation. Future research should investigate a wider range of common implementation outcomes for OeMH interventions that also focus on a wider set of common mental health problems in the workplace. This scoping review’s findings can be critically leveraged by discerning decision-makers to improve the reach, effectiveness, adoption, implementation, and maintenance of OeMH interventions.
MEKANISME PERALIHAN HAK GUNA BANGUNAN MENJADI HAK MILIK BERDASARKAN PERATURAN MENTERI NEGARA AGRARIA/KEPALA BADAN PERTANAHAN NASIONAL NOMOR 6 TAHUN 1998 DI KECAMATAN MARO SEBO KABUPATEN MUARO JAMBI
Authors: Claresa Yolanda , Fitria Fitria 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui dan menganalisis Mekanisme Peralihan Hak Guna Bangunan menjadi Hak Milik di Kantor Badan Pertanahan Kabupaten Muaro Jambi dan aspek-aspek yang menjadi penghambat dalam pelaksanaan peralihan Hak tersebut. Penelitian ini menggunakan Metode penelitian Yuridis Empiris. Hasil Penelitian menunjukkan Peralihan Hak Guna Bangunan menjadi Hak Milik dapat dilihat dengan adanya Keputusan Menteri Negara Agraria/ Kepala Badan Pertanahan Nasional Nomor 6 Tahun 1998 tentang Pemberian Hak Milik Atas Tanah untuk Rumah Tinggal, masyarakat atau pemilik rumah yang berstatus Hak Guna Bangunan dapat meningkatkan status hak tanahnya menjadi Hak Milik melalui peralihan hak atas tanah guna mendapatkan jaminan perlindungan dan kepastian hukum. Aspek-aspek yang menjadi penghambat dalam pelaksanaan peralihan Hak atas tanah dari Hak Guna Bangunan menjadi Hak Milik yaitu didalam melakukan peralihan hak atas tanah, masyarakat seringkali tidak melengkapi persyaratan berkas dan kurangnya pemahaman masyarakat tentang prosedur atau tata cara peralihan Hak Atas Tanah dari Hak Guna Bangunan menjadi Hak Milik. Selain itu juga, dari pihak instansi yang berwenang yaitu Kantor Badan Pertanahan juga belum sepenuhnya melaksanakan peralihan Hak atas tanah dengan baik. Penelitian ini diharapkan menjadi masukan bagi Pemerintah dalam hal ini adalah Badan Pertanahan Nasional untuk meningkatkan kinerja dalam pelayanan publik, melakukan sosialisasi kepada masyarakat tentang arti penting melakukan peralihan hak atas tanah serta meningkatkan pelaksanaan peralihan hak atas tanah yang belum optimal.
Exploring the Potential Impact of Relationship Characteristics and Customer Attributes on the Outcomes of Third-party Logistics Arrangements
Authors: KNEMEYER A. MICHAEL , MURPHY PAUL R. 
Published: June 2022

Abstract
This article uses a relationship marketing perspective as the basis for evaluating third-party logistics arrangements. In particular, the study investigates whether 3PL relationship outcomes (e.g., customer retention, service recovery) are influenced by select relationship characteristics (e.g., communication, reputation) and/or select customer attributes (e.g., firm size, number of outsourced logistics functions). The article reports the findings from a study of 388 users of third-party logistics services that investigated these potential linkages. Regression analyses were applied to the constructs of interest in order to learn about the degree of influence. The findings suggest that “substance trumps style” in the sense that relationship characteristics, rather than customer attributes, have the more significant impacts on relationship outcomes.
Studies of Trends in Third-Party Logistics Usage: What Can We Conclude?
Authors: ASHENBAUM BRYAN , MALTZ ARNOLD , RABINOVICH ELLIOT 
Published: June 2022

Abstract
This article evaluates the various longitudinal studies of third-party logistics (3PL) usage and proposes methods and approaches to improve the rigor of future research in this area. Three well-established methodologies for combining the results of multiple studies are reviewed (literature reviews, meta-analysis, and repeated survey analysis), and then considered in application to the findings of the various 3PL usage studies since 1991. Beginning with an overview of the results that emerge from simply combining and comparing the key longitudinal data, the article moves on to a more detailed analysis of the measurement scales, data collection methods, and samples utilized in the different 3PL surveys. The article ends with concrete recommendations for reorienting the ongoing surveys to increase their rigor and validity, and thus increase their predictive value to both academics and logistics managers.
Interfirm Linkages and the Structure and Evolution of the Danish Trucking Industry
Authors: SORNN-FRIESE HENRIK 
Published: June 2022

AbstractStudies of structure and evolution in the European trucking industry have, possibly mistakenly, predicted the shakeout of small motor carriers and argued that only large carriers will be able to create value to shippers in the long run. This prediction is based on an essentially taken-for-granted premise that in the economic theory of industry evolution, the industry life cycle approach applies to the trucking industry. This article argues that it does, in fact, not apply well to this industry, which possesses characteristics that allow for quite different competitive dynamics. The argument is illustrated empirically by a case study of the Danish trucking industry in the 1990s. The study reveals that the Danish trucking industry moves towards increasingly organized markets with a few large carriers, some specialized and flexible small and medium-sized (SME) carriers with vertical and horizontal linkages, and many small carriers and independent owner-operators serving shippers and other carriers on a short-term basis. Adopting a knowledge-based perspective, the persistent coexistence of small, medium-sized, and large carriers can be attributed to the nature and dynamics of demand, the division of labor between different motor carriers, and changes in productive resources.
Impact of Immediate and Delayed Photo-activation of Self-adhesive Resin Cements on Bonding Efficacy and Water Uptake Under Simulated Pulpal Pressure
Authors: El-Damanhoury HM , Elsahn NA , Sheela S , Albasti AA , Jouma MJ , Albadich MA , Bastaty T , Taghva YS 
Published: June 2022

SUMMARY
This study investigated the effect of immediate versus delayed photo-activation on the bonding performance and water uptake of self-adhesive (SA) resin cements under simulated pulpal pressure (SPP). The occlusal dentin surface was exposed in 66 extracted third molars. Resin composite cylinders were cemented to dentin under SPP, with either RelyX Unicem 2 (RU) (3M Oral Care, St Paul, MN, USA) or Maxcem Elite (MC) (Kerr, Orange, CA, USA). Each cement group was equally divided into three groups (n=8 each) according to the time elapsed between placement and photo-activation: immediate activation (IM), 30-second delayed activation (D30), or 120-second delayed activation (D120). Shear bond strength (SBS) was measured, and the type of failure was determined using a stereomicroscope. Three additional samples from each experimental subgroup were used for confocal laser scanning microscopy (CLSM) analysis. A fluorescent dye solution was added to the pulpal fluid reservoir, then a CLSM was used to detect the dye distribution within the tooth-restoration interface. Two-way analysis of variance (ANOVA) and the Tukey post-hoc test were used to analyze the SBS results (α=0.05). D30 resulted in a significantly higher mean SBS in the two cement groups than IM and D120 (p&lt;0.05). RU showed significantly higher SBS values than MC regardless of the time of light activation (p&lt;0.05). RU showed less dye uptake confined to the cement-dentin interface compared to the MC groups, which showed dye uptake throughout the entire thickness of the cement layer and gap formation at the interface, especially in the D120 group. The 30-second photo-activation delay group significantly improved the bond strength of SA cements. Delaying the photo-activation to 120 seconds increased pulpal fluid uptake by SA cements and compromised the integrity of the bonded interfaces.
Implementasi Dimensi Connectedness Dalam Problem Based Learning Untuk Meningkatkan Koneksi Matematis Dan Disposisi Matematis
Authors: Mubarika Melinda Putri , Firmansyah Eka , Yulianie Lia 
Published: June 2022

Penelitian ini bertujuan untuk meningkatkan kemampuan koneksi dan disposisi matematis siswa melalui implementasi connectedness dari Productive Pedagogies Framework dalam Problem Based Learning.. Penelitian Tindakan Kelas ini menggunakan metode kombinasi (mixed methods) dengan desain sequential explanatory. Populasinya adalah siswa kelas VIII SMP Negeri 15 Bandung dengan jumlah sampel 63 orang siswa yang terbagi ke dalam kelas VIII – 1 dan kelas VIII-3. Data dalam penelitian ini diperoleh melalui tes kemampuan koneksi matematis, angket disposisi matematis siswa, lembar observasi kegiatan pembelajaran dan wawancara. Data yang diperoleh dianalisis dengan menggunakan Uji Statistik. Mann Whitney, Rank Spearman. Uji Independent Sample T – Test. Hasil penelitian menunjukkan bahwa, (1) Implementasi connectedness pada PBL dapat meningkatkan kemampuan koneksi matematis, (2) Implementasi connectedness pada PBL dapat meningkatkan disposisi matematis.