bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating bounds on the extended uncertainty principle metric through astrophysical tests
Authors: Ökcü Özgür , Aydiner Ekrem 
Published: April 2022

Abstract
In this paper, we consider the gravitational tests for the extended uncertainty principle (EUP) metric, which is a large-scale quantum correction to Schwarzschild metric. We calculate gravitational redshift, geodetic precession, Shapiro time delay, precession of Mercury and S2 star's orbits. Using the results of experiments and observations, we obtain the lower bounds for the EUP fundamental length scale

. We obtain the smallest bound

for gravitational redshift, and the largest bound

for the precession of S2's orbit.
Loss of Hepatic Small Heterodimer Partner Elevates Ileal Bile Acids and Alters Cell Cycle-related Genes in Male Mice
Authors: Shaw Ryan Philip Henry , Kolyvas Peter , Dang Nathanlown , Hyon Angela , Bailey Keith , Anakk Sayeepriyadarshini 
Published: April 2022

Abstract
Small heterodimer partner (Shp) regulates several metabolic processes, including bile acid levels, but lacks the conserved DNA binding domain. Phylogenetic analysis revealed conserved genetic evolution of SHP, FXR, CYP7A1, and CYP8B1. Shp, although primarily studied as a downstream target of Farnesoid X Receptor (Fxr), has a distinct hepatic role that is poorly understood. Here, we report that liver-specific Shp knockout (LShpKO) mice have impaired negative feedback of Cyp7a1 and Cyp8b1 on bile acid challenge and demonstrate that a single copy of the Shp gene is sufficient to maintain this response. LShpKO mice also exhibit elevated total bile acid pool with ileal bile acid composition mimicking that of cholic acid-fed control mice. Agonistic activation of Fxr (GW4064) in the LShpKO did not alter the elevated basal expression of Cyp8b1 but lowered Cyp7a1 expression. We found that deletion of Shp led to an enrichment of distinct motifs and pathways associated with circadian rhythm, copper ion transport, and DNA synthesis. We confirmed increased expression of metallothionein genes that can regulate copper levels in the absence of SHP. LShpKO livers also displayed a higher basal proliferation that was exacerbated specifically with bile acid challenge either with cholic acid or 3,5-diethoxycarbonyl-1,4-dihydrocollidine but not with another liver mitogen, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene. Overall, our data indicate that hepatic SHP uniquely regulates certain proliferative and metabolic cues.
Inhibition of NR5A1 Phosphorylation Alleviates a Transcriptional Suppression Defect Caused by a NovelNR0B1Mutation
Authors: Abe Ichiro , Tanaka Tomoko , Ohe Kenji , Fujii Hideyuki , Nagata Mai , Ochi Kentaro , Senda Yuki , Takeshita Kaori , Koga Midori , Kudo Tadachika , Enjoji Munechika , Yanase Toshihiko , Kobayashi Kunihisa 
Published: April 2022

AbstractContextMutations in the NR0B1 gene, also well-known as the DAX1 gene, are known to cause congenital adrenal hypoplasia associated with hypogonadotropic hypogonadism. The abnormal NR0B1 protein fails to suppress the transcription of promoters of steroidogenic enzymes, which are also targets of NR5A1 protein, also well-known as Ad4BP/SF-1 protein. Since NR5A1 and NR0B1 have antagonistic effects on steroidogenesis, the loss of function due to NR0B1 mutations may be compensated by inducing loss of function of NR5A1 protein.PatientA middle-aged man was diagnosed with congenital adrenal hypoplasia associated with hypogonadotropic hypogonadism and genetic analysis revealed him to have a novel NR0B1 mutation, c.1222C&gt;T(p.Gln408Ter).MethodsNR0B1 activity was evaluated in CLK1/4 inhibitor-treated 293T cells via immunoblotting and luciferase assays of the STAR promoter.ResultsTG003 treatment suppressed NR5A1 protein function to compensate for the mutant NR0B1 showing inhibited suppression of transcription. Immunoblotting analyses showed that the phosphorylation status of NR5A1 at Ser203 was attenuated by the CLK1/4 inhibitor.ConclusionThe specific reduction of NR5A1 phosphorylation by a CLK1/4 inhibitor may alleviate developmental defects in patients with NR0B1 mutations.
Pulse Wave Analysis Using the Pressure Recording Analytical Method to Measure Cardiac Output in Pediatric Cardiac Surgery Patients: A Method Comparison Study Using Transesophageal Doppler Echocardiography as Reference Method
Authors: Greiwe Gillis , Balfanz Vanessa , Hapfelmeier Alexander , Zajonz Thomas S. , Müller Matthias , Saugel Bernd , Schulte-Uentrop Leonie 
Published: April 2022

BACKGROUND:
Cardiac output (CO) is a key determinant of oxygen delivery, but choosing the optimal method to obtain CO in pediatric patients remains challenging. The pressure recording analytical method (PRAM), implemented in the MostCareUp system (Vygon), is an invasive uncalibrated pulse wave analysis (PWA) method to measure CO. The objective of this study is to compare CO measured by PRAM (PRAM-CO; test method) with CO simultaneously measured by transesophageal Doppler echocardiography (TEE-CO; reference method) in pediatric patients.

METHODS:
In this prospective observational method comparison study, PRAM-CO and TEE-CO were assessed in pediatric elective cardiac surgery patients at 2 time points: after anesthesia induction and after surgery. The study was performed in a German university medical center from March 2019 to March 2020. We included pediatric patients scheduled for elective cardiac surgery with arterial catheter and TEE monitoring. PRAM-CO and TEE-CO were compared using Bland-Altman analysis accounting for repeated measurements per subject, and the percentage error (PE).

RESULTS:
We included 52 PRAM-CO and TEE-CO measurement pairs of 30 patients in the final analysis. Mean ± SD TEE-CO was 2.15 ± 1.31 L/min (range 0.55–6.07 L/min), and mean PRAM-CO was 2.21 ± 1.38 L/min (range 0.55–5.90 L/min). The mean of the differences between TEE-CO and PRAM-CO was −0.06 ±0.38 L/min with 95% limits of agreement (LOA) of 0.69 (95% confidence interval [CI], 0.53–0.82 L/min) to −0.80 L/min (95% CI, −1.00 to −0.57 L/min). The resulting PE was 34% (95% CI, 27%–41%).

CONCLUSIONS:
With a PE of <45%, PRAM-CO shows clinically acceptable agreement with TEE-CO in hemodynamically stable pediatric patients before and after cardiac surgery.
A prediction model for pathological findings after neoadjuvant chemoradiotherapy for resectable locally advanced esophageal squamous cell carcinoma based on endoscopic images using deep learning
Authors: Kawahara Daisuke , Murakami Yuji , Tani Shigeyuki , Nagata Yasushi 
Published: April 2022

Objectives: To propose deep-learning (DL)-based predictive model for pathological complete response rate for resectable locally advanced esophageal squamous cell carcinoma (SCC) after neoadjuvant chemoradiotherapy (NCRT) with endoscopic images. Methods and Material: This retrospective study analyzed 98 patients with locally advanced esophagus cancer treated by preoperative chemoradiotherapy followed by surgery from 2004 to 2016. The patient data were split into two sets: 72 patients for the training of models and 26 patients for testing of the model. Patients was classified into two groups with the LC (Group I: responder and Group II: non-responder). The scanned images were converted into joint photographic experts group (JPEG) format and resized to 150 × 150 pixels. The input image without imaging filter (w/o filter) and with Laplacian, Sobel, and wavelet imaging filters deep-learning model to predict the pathological CR with a convolution neural network (CNN). The accuracy, sensitivity, and specificity, the area under the curve (AUC) of the receiver operating characteristic were evaluated. Results: The average of accuracy for the cross-validation was 0.64 for w/o filter, 0.69 for Laplacian filter, 0.71 for Sobel filter, and 0.81 for wavelet filter, respectively. The average of sensitivity for the cross-validation was 0.80 for w/o filter, 0.81 for Laplacian filter, 0.67 for Sobel filter, and 0.80 for wavelet filter, respectively. The average of specificity for the cross-validation was 0.37 for w/o filter, 0.55 for Laplacian filter, 0.68 for Sobel filter, and 0.81 for wavelet filter, respectively. From the ROC curve, the average AUC for the cross-validation was 0.58 for w/o filter, 0.67 for Laplacian filter, 0.73 for Sobel filter, and 0.83 for wavelet filter, respectively. Conclusions: The current study proposed the improvement the accuracy of the DL-based prediction model with the imaging filters. With the imaging filters, the accuracy was significantly improved. The model can be supported to assist clinical oncologists to have a more accurate expectations of the treatment outcome. Advances in knowledge: The accuracy of the prediction for the local control after radiotherapy can improve with the input image with the imaging filter for deep learning.
Post-mortem perinatal imaging: what is the evidence?
Authors: Shelmerdine Susan C , Arthurs Owen J 
Published: April 2022

Post-mortem imaging for the investigation of perinatal deaths is an acceptable tool amongst parents and religious groups, enabling a less invasive autopsy examination. Nevertheless, availability is scarce nationwide, and there is some debate amongst radiologists regarding the best practice and optimal protocols for performing such studies. Much of the published literature to date focusses on single centre experiences or interesting case reports. Diagnostic accuracy studies are available for a variety of individual imaging modalities (e.g. post-mortem CT, MRI, ultrasound and micro-CT), however, assimilating this information is important when attempting to start a local service. In this article, we present a comprehensive review summarising the latest research, recently published international guidelines, and describe which imaging modalities are best suited for specific indications. When the antenatal clinical findings are not supported by the post-mortem imaging, we also suggest how and when an invasive autopsy may be considered. In general, a collaborative working relationship within a multidisciplinary team (consisting of radiologists, radiographers, the local pathology department, mortuary staff, foetal medicine specialists, obstetricians and bereavement midwives) is vital for a successful service.
Impact of Long COVID on health and quality of life
Authors: O’ Mahony Liam , Buwalda Tanja , Blair Matthew , Forde Brian , Lunjani Nonhlanhla , Ambikan Anoop , Neogi Ujjwal , Barrett Peter , Geary Eoin , O'Connor Nuala , Dineen Jennifer , Clarke Gerard , Kelleher Eric , Horgan Mary , Jackson Arthur , Sadlier Corinna 
Published: April 2022

Background: The aim of this study was to measure the impact of post-acute sequelae of COVID-19 (PASC) on quality of life, mental health, ability to work and return to baseline health in an Irish cohort. Methods: We invited individuals with symptoms of COVID-19 lasting more than 14 days to participate in an anonymous online questionnaire. Basic demographic data and self-reported symptoms were recorded. Internationally validated instruments including the patient health questionnaire somatic, anxiety and depressive symptom scales (PHQ-SADS), the Patient Health Questionnaire-15 (PHQ-15) and Chadler fatigue scale (CFQ) were used. Results: We analysed responses from 988 participants with self-reported confirmed (diagnostic/antibody positive; 81%) or suspected (diagnostic/antibody negative or untested; 9%) COVID-19. The majority of respondents were female (88%), white (98%), with a median age of 43.0 (range 15 – 88 years old) and a median BMI of 26.0 (range 16 – 60). At the time of completing this survey, 89% of respondents reported that they have not returned to their pre-COVID-19 level of health. The median number of symptoms reported was 8 (range 0 to 33 symptoms), with a median duration of 12 months (range 1 to 20 months) since time of acute infection. A high proportion of PASC patients reported that they have a moderate or severe limitation in their ability to carry out their usual activities, 38% report their ability to work is severely limited and 33% report a moderate, or higher, level of anxiety or depression. Conclusion: The results of this survey of an Irish cohort with PASC are in line with reports from other settings, and we confirm that patients with PASC reported prolonged, multi-system symptoms which can significantly impact quality of life, affect ability to work and cause significant disability. Dedicated multidisciplinary, cross specialty supports are required to improve outcomes of this patient group.
Using the ‘Twelve tips for applying change models’ for undergraduate medical curriculum reform in Pakistan: Incorporating a new Trauma Evaluation and Management TEAM® course
Authors: Soomro Rufina , Ur Rehman Sheeraz , Ali Sobia , McKimm Judy 
Published: April 2022

Background: Trauma evaluation and management skills are not taught enough in medical school undergraduate curriculums worldwide. It has been recommended by trauma educators to incorporate trauma training in medical schools’ curriculum as first-line management of trauma cases is usually required by junior doctors in ERs. The introduction of formal trauma training in the form of the Trauma Evaluation and Management TEAM® course is a change introduced into the curriculum. Even when introducing such a simple change, certain factors need to be considered including the stakeholders’ apprehensions and involvement, the complexity of the internal and external environment, cultural context and political influences, and finally the psychological impact of change. Methods: Based primarily on the “Twelve tips for applying change models to curriculum design, development and delivery” by McKimm and Jones (2018), these 12 tips provide educators, involved in curriculum or program development, a practical example of the systematic and organized outlines to improve medical curricula. Results & Conclusions: While addressing these factors, this framework can guide educators for the successful development and implementation of a suggested change in the existing curriculum.
The effectiveness of incentives for research participation: A systematic review and meta-analysis of randomized controlled trials
Authors: Abdelazeem Basel , Abbas Kirellos Said , Amin Mostafa Atef , El-Shahat Nahla Ahmed , Malik Bilal , Kalantary Atefeh , Eltobgy Mostafa 
Published: April 2022

Background
Recruitment plays a vital role in conducting randomized control trials (RCTs). Challenges and failure of proper recruitment lead to early termination of trials. Monetary incentives have been suggested as a potential solution to these challenges. Therefore, we aimed to do a systematic review and analysis to evaluate the effect of incentives on the number of participants willing to consent to and participate in RCTs.

Methods
Electronic databases were systematically searched from inception to September 23rd, 2021, using the following keywords: payments, incentive, response, participation, enrollment, randomized, randomization, and RCT. The Cochrane Risk of Bias tool was used to assess the quality of the included trials. Risk ratios (RRs) were calculated with their corresponding 95% confidence interval (CI). All analyses were done with the random-effects model. We used Revman software to perform the analysis.

Results
Six RCTs with 6,253 Participants met the inclusion criteria. Our analysis showed significant improvement in response rate (RR: 1.27; 95% CI: 1.04, 1.55; P = 0.02) and consent rates (RR: 1.44; 95% CI: 1.11, 1.85; P = 0.006) when an incentive payment was offered to participants. Even a small amount of incentive showed significant improvement in both consent (RR: 1.33; 95% CI: 1.03, 1.73; P = 0.03) and response rates (RR: 1.26; 95% CI: 1.08, 1.47; P = 0.004).

Conclusion
In conclusion, our meta-analysis demonstrated statistically significant increases in the rate of consent and responses from participants when offered even small monetary value incentives. These findings suggest that incentives may be used to reduce the rate of recruitment failure and subsequent study termination. However, further RCTs are needed to establish a critical threshold beyond which incentive amount does not alter response rates further and the types of RCTs in which financial incentives are likely to be effective.
A compendium of optimization algorithms for distributed linear-quadratic MPC
Authors: Stomberg Gösta , Engelmann Alexander , Faulwasser Timm 
Published: April 2022

Abstract
Model Predictive Control (MPC) for {networked, cyber-physical, multi-agent} systems requires numerical methods to solve optimal control problems while meeting communication and real-time requirements. This paper presents an introduction on six distributed optimization algorithms and compares their properties in the context of distributed MPC for linear systems with convex quadratic objectives and polytopic constraints. In particular, dual decomposition, the alternating direction method of multipliers, a distributed active set method, an essentially decentralized interior point method, and Jacobi iterations are discussed. Numerical examples illustrate the challenges, the prospect, and the limits of distributed MPC with inexact solutions.
Uncertain AoI in stochastic optimal control of constrained LTI systems
Authors: Hahn Jannik , Stursberg Olaf 
Published: April 2022

Abstract
This paper addresses finite-time horizon optimal control of control structures with shared communication network. To cope with the uncertainties, induced by network imperfections and exogenous disturbances at the same time, an optimization-based control scheme is proposed. It uses a disturbance feedback and the Age of Information (AoI), a receiver-based measure of communication delays, as central aspects. The disturbance feedback is an extension of the control law used for balanced stochastic optimal control. Balanced optimality is understood as a compromise between minimizing expected deviations from the reference and the minimization of the uncertainty of future states. Time-varying state constraints as well as time-invariant input constraints are considered, and the controllers are synthesized by semi-definite programming.
Automatisierte Erzeugung von Modellen und Beobachtern für physikalisch vernetzte Systeme
Authors: Pfeifer Martin 
Published: April 2022

Zusammenfassung
Diese Arbeit befasst sich mit der Automatisierung der physikorientierten Modellbildung und des darauf basierenden Beobachterentwurfs. Hierzu werden Port-Hamiltonsche Methoden entwickelt, die erstmals eine durchgängige Automatisierung der Modellbildung und des Beobachterentwurfs für eine große Klasse physikalisch vernetzter Systeme ermöglichen.
Evaluation of the AFIAS-1 thyroid-stimulating hormone point of care test and comparison with laboratory-based devices
Authors: Dierks Sascha , Andag Reiner , Gauss Friederike , Budde Kathrin , Francke Paul , Peschka Manuela , Fischer Andreas , Schanz Julie , Petersmann Astrid 
Published: April 2022

Abstract

Objectives
Thyroid-stimulating hormone (TSH) is the routine primary screening test to assess thyroid function and rapid measurement of TSH levels is highly desirable especially in emergency situations. In the present study, we compared the analytical performance of a commercially available point-of-care test (AFIAS-1) and five laboratory-based systems.

Methods
Left over material of 60 patient plasma samples was collected from patient care and used in the respective assay. For statistical analysis of the produced data Bland-Altman and Passing-Bablok regression analysis were applied.

Results
Good correlation (r=0.982 or higher) was found between all devices. Slopes from regression analysis ranged from 0.972 (95% CI: 0.927–1.013) to 1.276 (95% CI: 1.210–1.315). Among the compared devices, imprecision was high in terms of coefficient of variation (CV=10.3%) for low TSH concentrations and lower (CV=7.3%) for high TSH concentrations. Independent of the method used, we demonstrated a poor standardization of TSH assays, which might impact clinical diagnosis e.g. of hyperthyreosis.

Conclusions
This study shows that the point-of-care (POC) test AFIAS-1 can serve as an alternative to laboratory-based assays. In addition the data imply that better standardization of TSH measurements is needed.
Simultaneously enhance the fire safety and mechanical properties of PLA by incorporating a cyclophosphazene-based flame retardant
Authors: Yu Wenhao , Yang Weijun , Xu Pengwu , Dai Chunfa , Liu Qingsheng , Ma Piming 
Published: April 2022

Abstract
The application of poly(lactic acid) (PLA) has been limited in flame-retardant field, and flame-retardant modification usually deteriorates its mechanical properties. In this study, a reactive flame-retardant hexa(ethylene oxide)-cyclotriphosphazene (HCCP-EP) was synthesized and used to improve the fire retardancy of PLA. As a result, the limiting oxygen index of PLA increased from 19.5% to 27.3% with an addition of 3 wt% HCCP-EP, and the PLA/HCCP-EP blend reached to underwriters laboratories (UL)-94 V-0 rating. The cone calorimeter test results showed that the peak heat release rate and total heat release of PLA decreased by 12.6% and 18.5%, respectively. Interestingly, the tensile strength of PLA increased slightly after the incorporation of HCCP-EP. The improved mechanical properties are ascribed to the fine dispersion of HCCP-EP and the coupling reaction between the epoxy groups of the HCCP-EP and the terminal groups of PLA during the melt processing.
N-fold Darboux transformation and exact solutions for the nonlocal Fokas–Lenells equation on the vanishing and plane wave backgrounds
Authors: Li Li , Liu Yiyan , Yu Fajun 
Published: April 2022

Abstract
In this paper, we propose and investigate the reverse-space–time nonlocal nonlinear Fokas–Lenells equation by the idea of Ablowitz and Musslimani. The reverse-space–time Fokas–Lenells equation, associated with a 2 × 2 matrix Lax pair, is the important integrable system, which can be reduced to the nonlocal Fokas–Lenells equation. Based on its Lax pair, we construct nonlocal version of N-fold Darboux transformation (DT) for the Fokas–Lenells equation, and obtain two kinds of soliton solutions from vanishing and plane wave backgrounds. Further some novel one-soliton and two-soliton are derived with the zero and nonzero seed solutions through complex computations, including the bright soliton, kink soliton and breather wave soliton. Moreover, various graphical analyses on the presented solutions are made to reveal the dynamic behaviors, which display the elastic interactions between two solitons and their amplitudes keeping unchanged after the interactions except for the phase shifts. It is clearly shown that these solutions have new properties which differ from ones of the classical Fokas–Lenells equation.