bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flushing of the Follicles in Ovum Pick-up Procedures Gives a Better Chance for Pregnancy in Low Ovarian Reserve Patients
Authors: Oral Serkan , Şişmanoğlu Alper 
Published: October 2022

Abstract
Background
This study aims compare the pregnancy and live birth rates between the oocytes retrieved without follicular flushing FF(-) in the oocyte pick-up (OPU) procedure performed in women with diminished ovarian reserve (DOR) and those retrieved by follicular flushing FF(+).
Results
The study was conducted among patients diagnosed with DOR according to Bologna criteria and applied to the clinic for IVF between 2017–2020. A total of 358 infertile women with follicles three and below on the hCG day, between the ages of 21 and 42, without severe male factor, without uterine anomaly, without uterine surgery, and who did not undergo PGD were included in the study. Each follicle was aspirated once in the OPU procedure, and if a follicle was retrieved, it was moved to the other follicle. If the follicle could not be retrieved, the oocyte was tried to be retrieved by flushing a maximum of 3 times. The number of oocytes retrieved, clinical pregnancy rate, and live birth rate were compared. Since all the oocytes retrieved in 143 patients were retrieved directly without the need for FF, it was named FF(-) group. Since at least one oocyte of the remaining 215 patients was retrieved by performing FF, it was named FF(+) group. Since some of the oocytes retrieved from 112 patients in the FF(+) group were retrieved with FF and some without FF, they were excluded from the study, and the remaining 103 cases formed the FF(+) group a total of 246 patients were compared. The mean number of MII oocytes ,the pregnancy rates, rates of live births and the abortion rates between two groups did not show any statistical difference.
Conclusion
FF applied during oocyte retrieval in DOR did not positively affect the number of retrieved oocytes, clinical pregnancy, and live birth rates even doing this may decrease the pregnancy rate because of the probable low quality egg but we should not forget that if we did not do flushing after once we aspirated the follicle we would not be able to obtain any pregnancy at all in this patients.
Avances y limitaciones en la configuración del Ecosistema Colombiano de Cooperación Sur-Sur y Triangular
Authors: Nivia-Ruiz Fernando , Prieto Cardozo Jorge Enrique 
Published: October 2022

El Banco Islámico de Desarrollo elaboró, en 2020, un marco de análisis denominado Ecosistema Nacional de Cooperación Sur-Sur y Triangular, compuesto por siete pilares que interactúan, se complementan y coexisten sin un orden jerárquico, buscando maximizar las contribuciones de esta cooperación al desarrollo de un país. Tomando como referencia dicho marco, este artículo –utilizando un diseño de investigación mixto con preponderancia cualitativo, basado en la revisión documental y la técnica de la entrevista–, establece y analiza los principales avances y limitaciones actuales que enfrenta Colombia en la configuración de tal ecosistema. Esta investigación valora y contrasta los progresos alcanzados por Colombia en cada pilar del ecosistema, concluyendo que este modelo es posible aplicarlo en el país, en donde, si bien hay avances en todos los pilares, lo son más significativos en términos de capacidades instituciones y lineamientos orientadores (Pilares 2 y 3), y presupuestales (Pilar 6). En contraste, mayores son los retos para alcanzar una decidida voluntad política y una narrativa que posicione y respalde la Cooperación Sur-Sur y Triangular colombiana (Pilar 1). Finalmente, se identificó que hay datos escasos para monitorear y evaluar las contribuciones al desarrollo de esta cooperación (Pilar 4), y se mantiene una limitada participación de actores, altamente concentrada en entidades públicas del nivel nacional (Pilar 5).
Palabras clave: Cooperación; Desarrollo; Ecosistema; Pilar; Colombia.
Ciencia, innovación y cooperación científica
Authors: Romeu Belkis , Hernández Escolar Jacqueline , Blanco-Rangel Ibelis 
Published: October 2022

El presente dossier de la Revista Internacional de Cooperación y Desarrollo subraya la interrelación entre la ciencia, la innovación y la cooperación científica nacional e internacional en tiempos donde la pandemia de la COVID-19 ha impuesto una crisis sin precedente y un desafío en todos los ámbitos. En esta edición, las contribuciones recibidas fueron mayormente de Colombia.
El contenido de este dossier compuesto por cuatro artículos resulta interesante para la comunidad científica, profesionales de diversas áreas del conocimiento, relaciones internacionales y tomadores de decisiones, porque la interacción entre ciencia, innovación y diplomacia propicia un terreno común para que la comunidad científica y diplomática puedan crear confianza y entendimiento mutuo en pro del desarrollo de nuestras sociedades y de los retos globales en salud.
Assessment of groundwater at Kurukshetra district
Authors: Rakesh Gandikota , Tiwari N. K. 
Published: October 2022

Abstract
Mankind depends on surface water and groundwater resources to meet basic requirements. Groundwater is a limited resource that can be replenished. Instead of surface water, groundwater can be an alternate supply to meet a region's water demand for household, agriculture, and industrial uses. As a result, a thorough assessment is required to ensure the resource's long-term viability. The main aim of the research is to identify potential zones using remote sensing and quantification of groundwater resources. In the present study, the potential zones were identified by using the weighted overlay technique in ArcGIS software by considering eight influencing factors, and the estimation of groundwater was carried out using GEC 2015 methodology. The study discovered that the study area has a good potentiality of groundwater in the southern region. Further estimates were made for the period April 2020–March 2021 by taking into account recharge by rainfall, irrigation return flow, seepage by canals, and draft by industries, domestic, irrigation, and evapotranspiration. The research reveals that the net groundwater recharge of 0.16284361 million ha-m was depleted in the study area. This analysis concludes that the groundwater in the study area is critical and becoming an overexploited zone.
Effect of sediment gradation on scour by symmetric crossing jets: an experimental investigation
Authors: Naini Shayan , Karami Hojat , Hosseini Khosrow 
Published: October 2022

Abstract
A laboratory study with 162 experiments was designed and conducted to investigate the effect of three non-uniform sediment samples on the scour morphology by the symmetric crossing jets. The bed sediment materials with close median diameter values and different non-uniformities were utilized to investigate the scour at various crossing angles. The results were also compared with the equivalent single jet. The proper novel relationships were presented to predict the scour hole depth, and dimensions. The results showed that at a crossing angle of 30° with low and medium tailwater depth, the scour depth increases with increasing the non-uniformity of the bed materials. At the crossing angle of 30°, the armor layer was created perfectly that was thick on the bottom of the scour hole, but for the crossing angles of 70° and 110° it was thin and was a mixture of the coarse and fine particles. At low tailwater depth at the crossing angles of 70° and 110°, by increasing the non-uniformity of the sediments, the scour tended to be more asymmetric. At the high tailwater depth, for the crossing angles of 70° and 110° the scouring was less than that of the crossing angle of 30° and single jet.
Inhibitors of Bacterial Signal Peptidases
Authors: Black M.T. , Bruton G. 
Published: October 2022

Abstract:
Signal peptidases are serine endoproteinases responsible for the proteolytic removal of N-terminal amino acid signal sequences from pre-secretory proteins in all cellular lifeforms including bacteria. The demonstrated essentiality of the enzymatic acti­
vity and the ubiquitous occurrence in bacteria, coupled with the significant molecular differences between bacterial signal peptidases and those of eukaryotes, define these enzymes as potential molecular targets for the development of novel antibacterial agents. Few compounds are known to inhibit bacterial signal peptidases and the most significant advance in SPase inhibition has been the discovery of penem systems as time dependent irreversible inhibitors. They are thought to act via acylation of the active site serine. SPases are only acylated by the SS. penem stereochemistry, a stereochemical preference mirrored in other azetidinone containing inhibitors. The implications of this is that the active site serine of SPases approach their substrate from the opposite side of the peptidic backbone to that of all other serine protease families whose structures are known. The activity of penems is significantly enhanced by the incorporation of a C6 hydroxyethyl substituent, thought to bind into the S1 pocket of the enzyme. Penem inhibition of SPases has been demonstrated in vitro, in isolated enzyme assays, and in vivo in pulse-chase assays.
Central Control of Feeding Behavior by Neuropeptide Y
Authors: Zimanyi Ildiko Antal , Fathi Zahra , Poindexter Graham S. 
Published: October 2022

Abstract:
Obesity is a serious health problem in the Western societies, therefore its treatment has become the subject of intense interest in the scientific community. A significant number of recent publications enlist different central and peripheral factors which play important roles in the regulation of food intake, body weight and energy expenditure. Neuropeptide Y, a 36 amino acid peptide, which is quite abundant in the brain, seems to be one of the more important players in these regulations. Recently five NPY receptors have been cloned and pharmacological evidence strongly supports the existence of a sixth receptor. There are many contradictory findings regarding which NPY receptor mediates the effect of NPY on.food intake. This article will review the effects of NPY on the regulation of food intake and energy expenditure and will discuss the pharmacological and molecular evidence as to which NPY receptor(s) mediate this effect. The review will also summarize the progress which has been made in the design of novel NPY-ergic ligands, especially NPY receptor antagonists, for potential use in the treatment of obesity.
Genomics in the Real World
Authors: Wiley Steven R. 
Published: October 2022

Abstract:
The term genomics has evolved into a catch-all term for a variety of information intensive biological methodologies. While the promise of genomics in the bio/pharmaceutical industry is great, its impact on the drug discovery pipeline has not yet been realized, excluding a few notable exceptions. As companies acquire several years of experience in working with genomic data, it is likely that the impact on the discovery process will slowly emerge as we learn to integrate these new technologies into individual discovery programs. It is clear that extracting novel biologically valid targets targets from exponentially growing amounts of sequence data requires time and considerable investment in biological research infrastructure. In order to accelerate the process of target validation, a variety of functional genomics technologies are also being developed to try to predict the effect of inhibitory compounds in advance of development. Resources spent on early stage exploratory efforts such as these can pay off by improving the success rate for screening and medicinal chemistry.
Humeral Greater Tuberosity Size Measurement at CT Multiplanar
Reconstruction
Authors: Guo Ai , Li Zhiyao , Ma Lifeng , Yin Wei , Wu Yingjie , Qi Zhengrong , Yang Bo , Zhang Jingxin , Li Qiang 
Published: October 2022

Background:
This study was designed to explore the precise size of the greater tuberosity of
humerus in the Chinese population.

Methods:
The radiologic study was performed on 66 computer tomography (CT) of the shoulder from
the CTs hospital’s scan database of the out-patient department from December 2018 to February 2020,
including 26 women and 40 men with a mean age of 36.79 ± 9.17 years, with 41 right and 25 left
shoulders. The width, height and thickness of the greater tuberosity were measured on CT image multiplanar
reconstructions (MPR), which was independently conducted by two observers.

Results:
The average width was 31.39±2.74 (25.65-36.85) mm. The average height was 27.11±2.57
(21.05-33.50) mm. The average thickness was 11.45±1.18 (9.15-14.30) mm. The average proximal
humerus (PH) thickness was 48.98±3.53 (41.40-55.20) mm. There were no significant differences in
greater tuberosity (GT) width, GT height, GT thickness and PH thickness between the two observers.
The total PH thickness was 51.06±2.30 (45.70-55.20) mm and 45.79±2.57 (41.40-51.25) mm for male
and female cases. Gender has a significant impact on the results, men had a larger GT than women.

Conclusion:
We got the precise size of the humeral greater tuberosity. These data provided important
information for further research and clinical practice. The measuring the greater tuberosity with CT
image MPR has good reliability.
A Study of Couples' Behaviour during the State Regulated COVID-19 Lockdown in a South Asian Country
Authors: Jayawardane Thesara V.P. , Wickramasinghe Vathsala 
Published: October 2022

Aims:
When assessing the ill-effects this pandemic has brought to humans, one of the most important factors is the psychological influence it has caused on married couples. The study is designed to understand whether they suffer from fears of financial situation/uncertainty and the role of resource availability on the level of adjustment of spouses.

Objective:
The objectives of this study were to identify whether individuals suffer from fears of financial situation and uncertainty, to analyse the level of adjustment of spouses, to investigate the resources available for spouses, and to understand whether resource availability moderates the relationship between individuals' fears on financial situation/uncertainty and the level of adjustment of spouses.

Methods:
An online survey was conducted among a chosen random sample and data were collected from 301 participants who were adults 25 years or older, residing in the Western Province of Sri Lanka. Statistical analysis was performed to identify the moderator effect of resources available for spouses.

Results:
The results showed that COVID-19 created uncertainty and fear of financial situation among married couples and, it was concluded that cultural beliefs and support extended from their respective families contributed to the adjustment of Sri Lankan spouses, who managed to remain in stable relationships during the global crisis as a result.

Conclusion:
The study concluded the support extended from the families and cultural beliefs contributed significantly to the adjustment of spouses who managed to stay strong during the global crisis.
The beneficial effects of pomegranate (Punica granatum L.) consumption on human health: a review
Authors: Napoli Agnese Di , Germani Federico , Parisi Francesco , Zucchetti Pietro 
Published: October 2022

The pomegranate (Punica granatum L.) is a small tree or shrub,
which is grown in large parts of the world. The medicinal properties of
this plant are known since ancient times and are due to the
phytochemical constituents found in the plant. This review describes the
therapeutic effects of pomegranate, which are reported in the scientific
literature. We performed a literature search, using the PubMed
database. We utilised this database to find the research articles
published between 2000 and 2021, showing the medicinal properties of
oral intake of pomegranate. We included 55 research articles
and we found 11 beneficial effects of pomegranate consumption on human
health. The therapeutic effects of this plant comprise those on
diabetes, the cardiovascular system, oxidative status, the nervous
system, cancer, colitis, metabolic syndrome and obesity, arthritis, the
reproductive system, parasitic infections and skin health.
Cardiovascular, antioxidant and antidiabetic activities are well
reported in the scientific literature and the medicinal properties of
pomegranate may be exerted by polyphenols found in the plant. This
review shows the health benefits of oral intake of pomegranate. The most
commonly reported beneficial activities of this plant are antioxidant,
cardiovascular and antidiabetic effects. The polyphenol constituents of
pomegranate may be responsible for its medicinal properties. Future
research is needed to define the therapeutic effects of oral intake of
this plant and the phytochemical compounds implicated in these
activities.
Keywords: Pomegranate, Polyphenols, Therapeutic effects,
Antioxidant, Cardiovascular, Antidiabetic
PREDIKSI BIDANG GELINCIR GERAKAN TANAH MENGGUNAKAN METODE ELECTRICAL RESISTIVITY TOMOGRAPHY (ERT)
Authors: Fadli Achmad Sri , Teuku Faisal Fathani  , Fikri Faris  
Published: October 2022

Terjadi longsor di area tebing batu (Rocky Wall) jalan akses fasilitas produksi pipa penyalur uap dan brine Pembangkit Listrik Tenaga Panas bumi (PLTP) milik PT. Pertamina Gothermal Energy (PT.PGE) di Kabupaten Muara Enim, Provinsi Sumatera Selatan, yang menyebabkan terjadinya penurunan produksi (derating) di PLTP akibat rusaknya fasilitas produksi dari sumur produksi klaster 1 ke PLTP. Tujuan dari penelitian ini untuk mengidentifikasi struktur lapisan bawah permukaan longsoran di area rocky wall dan untuk memprediksi kedalaman bidang gelincir (slip surface) berdasarkan nilai resistivitas lapisan tanah dengan metode geofisika ERT, sehingga metode geoteknik yang dipilih untuk penanganan longsor adalah tepat. Penelitian ini dilakukan dengan metode geofisika Electrical Resistivity Tomography (ERT) konfigurasi Wenner, Schlumberger dan Dipole-dipole dengan Ares II (Automatic Resistivity System II) sebagai peralatan utama ERT yang digunakan dalam pengambilan data. Luas daerah penelitian adalah 150 m × 200 m dengan jumlah pengukuran sebanyak 4 lintasan. Dari hasil pengolahan data pengukuran resistivitas menggunakan perangkat lunak Res2dinv dan Zondres2D, hasilnya menunjukkan bahwa sebaran batuan di daerah longsor rocky wall didominasi oleh lapisan breksi andesit lapuk dan lanau berpasir berlempung. Berdasarkan back analysis dan analisis stabilitas lereng sebelum kondisi longsor terjadi dan setelah longsor terjadi menggunakan Slope/W, didapatkan lapisan yang berpotensi menjadi bidang gelincir berkesesuaian pada kedalaman 10,43 m di bawah permukaan lereng.
Experimental infection with African Horse Sickness Virus in horses induces only mild temporal hematologic changes and acute phase reactant response
Authors: Schliewert Eva-Christina , Hooijberg Emma H. , Steyn Johannes S. , Potgieter Christiaan , Fosgate Geoffrey T. , Goddard Amelia 
Published: October 2022

Abstract

OBJECTIVE
African Horse Sickness (AHS) is a vector-borne disease endemic to sub-Saharan Africa caused by African Horse Sickness Virus (AHVS). Infections in naïve horses have high morbidity and mortality rates. AHS pathogenesis is not well understood; neither the hematologic changes nor acute phase response occurring during infection has been fully evaluated. The study’s objective was to characterize the hematologic changes and acute phase response during experimental infection with AHSV.

ANIMALS
4 horses negative for AHSV group-specific antibodies.

PROCEDURES
In this prospective, longitudinal study conducted between November 23 and December 2, 2020, horses were experimentally infected with AHSV, and blood samples were obtained before inoculation and then every 12 hours until euthanasia. Hematologic changes and changes for serum amyloid A (SAA) and iron concentration were evaluated over time using a general linear model including natural logarithm of sampling time.

RESULTS
All horses were humanely euthanized due to severe clinical signs typical of AHS. Median Hct increased significantly, and the median WBC count, monocyte count, eosinophil count, and myeloperoxidase index changed significantly in all horses over time. Horses developed marked thrombocytopenia (median, 48 X 103 cells/µL; range, 21 X 103 to 58 X 103 cells/µL) while markers of platelet activation also changed significantly. Median SAA increased and serum iron concentration decreased significantly over time.

CLINICAL RELEVANCE
Results indicated severe thrombocytopenia with platelet activation occurs during infection with AHSV. Changes in acute phase reactants SAA and iron, while significant, were unexpectedly mild and might not be useful clinical markers.
ПОВЕЗАНОСТ ОРГАНИЗАЦИОНЕ ПОСВЕЋЕНОСТИ, ЗАДОВОЉСТВА ЗАПОСЛЕНИХ И ДУЖИНЕ РАДНОГ СТАЖА У ОРГАНИЗАЦИЈИ
Authors: Станковић Маја 
Published: October 2022

У данашње време организациона посвећеност постаје кључна за опстанак и профитабилност свих предузећа, будући да је идентификована као витални чинилац у мотивисању запослених да буду везани за циљеве организације. У овом раду извршено је истраживање узрочних релација између организационе посвећености запослених и година рада, као и утицај организационе посвећености на укупно задовољство запослених.
ПОУЗДАНОСТ ОПТИЧКИХ ДЕТЕКТОРА ПОЖАРА У ЈАВНИМ ОБЈЕКТИМА
Authors: Savić Dejan 
Published: October 2022

У оквиру мастер рада извршена је анализа поузданости оптичких детектора пожара у јавним објектима, као дела система за аутоматску детекцију и алармирање у случају пожара. Ови системи су једна од кључних мера за смањење ризика и последица пожара. Идентификовани су и анализирани елементи који утичу на поузданост система, а све у циљу заштите и спасавања живота и здравља људи, материјалних добара и животне средине. На основу резултата истраживања предложене су мере за унапређење стања.
Nasal septal verrucous carcinoma presenting as a cutaneous horn
Authors: Wee Jia Jia , Kiong Kimberley LiQin 
Published: October 2022

Background:
Cutaneous horn arising from the nasal vestibule is an extremely rare entity with only four published case reports to date. Although cutaneous horns are commonly benign, the risk of it harboring a malignant or pre-malignant process is about one in three. Verrucous carcinoma is a variant of squamous cell carcinoma (SCC) that typically presents in the oral cavity, and very rarely in the nasal cavity.

Case Presentation:
We report a 78-year-old female who presented with a rapidly enlarging right naris cutaneous horn of 5 months duration. Computed tomography scan showed a heterogeneously enhancing mass at the right anterior nasal cavity with no overt bone or cartilage destruction. Differential diagnoses included seborrheic keratosis, actinic keratosis, viral wart, and malignant tumors such as SCC. She underwent an excision biopsy and histology confirmed the diagnosis of a pT1 verrucous SCC.

Conclusion:
Due to the rarity of the site of the disease, management of sinonasal verrucous carcinoma is generally derived from management options of other subsites in the head and neck region. The preferred treatment modality is surgical excision, while primary radiotherapy is an emerging treatment alternative in poor surgical candidates.