bluuebunny/crossref_metadata_2025_split huggingface dataset:
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Authors: Calls Aina , Torres‐Espin Abel , Tormo Marc , Martínez‐Escardó Laura , Bonet Núria , Casals Ferran , Navarro Xavier , Yuste Víctor J. , Udina Esther , Bruna Jordi 
Published: November 2022

AbstractObjectivesPeripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy. Unfortunately, the limited knowledge about the molecular mechanisms related to oxaliplatin neurotoxicity leads to a lack of effective treatments to prevent the development of this clinical condition. In this context, the present work aimed to determine the exact molecular mechanisms involved in the development of oxaliplatin neurotoxicity in a murine model to try to find new therapeutical targets.MethodsBy single‐cell RNA sequencing (scRNA‐seq), we studied the transcriptomic profile of sensory neurons and satellite glial cells (SGC) of the Dorsal Root Ganglia (DRG) from a well‐characterized mouse model of oxaliplatin neurotoxicity.ResultsAnalysis of scRNA‐seq data pointed to modulation of inflammatory processes in response to oxaliplatin treatment. In this line, we observed increased levels of NF‐kB p65 protein, pro‐inflammatory cytokines, and immune cell infiltration in DRGs and peripheral nerves of oxaliplatin‐treated mice, which was accompanied by mechanical allodynia and decrease in sensory nerve amplitudes.InterpretationOur data show that, in addition to the well‐described DNA damage, oxaliplatin neurotoxicity is related to an exacerbated pro‐inflammatory response in DRG and peripheral nerves, and open new insights in the development of anti‐inflammatory strategies as a treatment for preventing peripheral neuropathy induced by oxaliplatin.
Perovskite Solar Cell‐Gated Organic Electrochemical Transistors for Flexible Photodetectors with Ultrahigh Sensitivity and Fast Response
Authors: Song Jiajun , Tang Guanqi , Cao Jiupeng , Liu Hong , Zhao Zeyu , Griggs Sophie , Yang Anneng , Wang Naixiang , Cheng Haiyang , Liu Chun‐Ki , McCulloch Iain , Yan Feng 
Published: November 2022

AbstractPhotodetectors (PDs) are the building block of various imaging and sensing applications. However, commercially available PDs based on crystalline inorganic semiconductors cannot meet the requirements of emerging wearable/implantable applications due to their rigidity and fragility, which creates the need for flexible devices. Here, a high‐performance flexible PD is presented by gating an organic electrochemical transistor (OECT) with a perovskite solar cell. Due to the ultrahigh transconductance of the OECT, the device demonstrates a high gain of ≈106, a fast response time of 67 µs and an ultrahigh detectivity of 6.7 × 1017 Jones to light signals under a low working voltage (≤0.6 V). Thanks to the ultrahigh sensitivity and fast response, the device can track photoplethysmogram signals and peripheral oxygen saturation under ambient light and even provide contactless remote sensing, offering a low‐power and convenient way for continuous vital signs monitoring. This work offers a novel strategy for realizing high‐performance flexible PDs that are promising for low‐power, user‐friendly and wearable optoelectronics.
Catalytic Heteroannulation for the Synthesis of Quinoline‐4‐Carboxamides Bearing Axial Chirality
Authors: Zhang Xiang , Chen Bo‐Tao , Gao Peng , Song Rui‐Ping , Fang Fang , Han Dan‐Dan , Shao You‐Dong , Cheng Dao‐Juan 
Published: November 2022

AbstractAn iron(III) triflate catalyzed Friedländer‐type heteroannulation of 2‐(2‐aminophenyl)‐N,N‐dialkyl‐2‐oxoamides with α‐methylene carbonyl derivatives has been established, allowing facile access to a range of biologically interesting quinoline‐containing tertiary amides in good yields. Investigations into the configurational stability of products led to the identification of a new type of stable axially chiral quinoline‐4‐carboxamide bearing a sterically demanding phenylsulfonyl C3‐substituent. Subsequently, an enantioselective catalytic variant was attempted. The employment of copper(II) catalysis using a chiral bisoxazoline ligand was found to be capable of providing moderate enantiocontrol.magnified image
Oxygen‐Chlorine Chemisorption Scaling for Seawater Electrolysis on Transition Metals: The Role of Redox
Authors: Wexler Robert B. , Carter Emily A. 
Published: November 2022

AbstractTo clarify what controls species oxidation selectivity in seawater electrolysis, density functional theory (DFT) is used to identify chemisorption enthalpy trends and scaling relations for the simplest relevant adsorbates (O, Cl, and H) on relevant surfaces of 3d transition metals, as well as Pd and Pt, in face‐centered‐cubic and, if different, their ground‐state crystal structures. Approximations are tested for electron exchange‐correlation (XC) and van der Waals interactions to assess their ability to reproduce experimental adsorption enthalpies of H and O on Pt(111). The vdW‐uncorrected generalized gradient approximation to XC of Perdew, Burke, and Ernzerhof (PBE) agrees most closely with experiments. Using DFT‐PBE thereafter, it is determined that the O chemisorption enthalpy on this wide range of transition‐metal surfaces is proportional to the sum of first and second atomic ionization energies, akin to a Born–Haber cycle for a redox reaction, indicating that metal redox activity controls O chemisorption strength. Then it is shown that the O and Cl chemisorption enthalpies are strongly correlated, suggesting that the transition metals considered will oxidize unselectively water and Cl–. This strong correlation appears also for crystal reduction potentials of binary oxides and chlorides, indicating a fundamental challenge for future seawater electrode materials design.
The clinical features of OSTM1‐associated malignant infantile osteopetrosis: A retrospective, single‐center experience over one decade
Authors: Alotaibi Qutaibah , Dighe Manjiri , Aldaihani Saad 
Published: November 2022

AbstractMutation in OSTM1 give rise to the rarest and most lethal subtype of malignant infantile osteopetrosis (MIOP), and an improved understanding of OSTM1‐associated MIOP would help with informed decision‐making regarding symptom management and early palliative care referral. This retrospective study describes the clinical and laboratory features of patients with a genetic diagnosis of OSTM1 MIOP made between January 2011 and December 2021 in the Department of Pediatrics, Al‐Adan Hospital, Kuwait. Twenty‐two children had confirmed homozygous deletion in OSTM1 (13 females, nine males). Consanguinity was reported in almost all parents. 72.7% were diagnosed before the age of two months, most commonly incidentally with a high clinical suspicion. All 22 patients developed upper respiratory symptoms, hepatosplenomegaly, poor feeding, and had severe developmental delay. 80% of patients developed pain and/or irritability, and 40.9% were diagnosed with primary seizures. Bone fractures developed in 27% of patients, most likely iatrogenic, and some patients had hernia and gum abnormalities. The mean survival was 10.9 months. The clinical presentation, symptomatology, and mortality of our cohort were compared with other cases of OSTM1 MIOP identified through a comperhensive search of the PubMed database. The findings conclude that OSTM1 MIOP is a multi‐systemic disease with distinct clinical features, of which neurological complications are the most severe and include nociplastic pain and irritability. Although orthopedic complications influence the trajectory of most patients with other forms of osteopetrosis, OSTM1 MIOP is driven by its neurological complications. Hence, OSTM1 should be regarded as a neurodegenerative disease with osteopetrosis as a comorbidity that warrants early palliative care referral.
Palladium‐Catalyzed [6+2] Double Allene Annulation for Benzazocines Synthesis
Authors: Xu Haibo , Ma Shengming 
Published: November 2022

AbstractAn efficient double allene protocol for the formation of benzazocines has been developed. The reaction constitutes a highly regioselective palladium‐catalyzed formal [6+2] annulation of allenyl benzoxazinanones with terminal allenes forming the challenging 8‐membered cycles. Decent yields and excellent regioselectivity have been observed under mild conditions with a remarkable Z‐stereoselectivity for the exo‐cyclic C=C bonds. The synthetic potentials of benzazocine products have been demonstrated.
Enriching Surface‐Accessible CO2 in the Zero‐Gap Anion‐Exchange‐Membrane‐Based CO2 Electrolyzer
Authors: Xu Qiucheng , Xu Aoni , Garg Sahil , Moss Asger B. , Chorkendorff Ib , Bligaard Thomas , Seger Brian 
Published: November 2022

AbstractZero‐gap anion exchange membrane (AEM)‐based CO2 electrolysis is a promising technology for CO production, however, their performance at elevated current densities still suffers from the low local CO2 concentration due to heavy CO2 neutralization. Herein, via modulating the CO2 feed mode and quantitative analyzing CO2 utilization with the aid of mass transport modeling, we develop a descriptor denoted as the surface‐accessible CO2 concentration ([CO2]SA), which enables us to indicate the transient state of the local [CO2]/[OH−] ratio and helps define the limits of CO2‐to‐CO conversion. To enrich the [CO2]SA, we developed three general strategies: (1) increasing catalyst layer thickness, (2) elevating CO2 pressure, and (3) applying a pulsed electrochemical (PE) method. Notably, an optimized PE method allows to keep the [CO2]SA at a high level by utilizing the dynamic balance period of CO2 neutralization. A maximum jCO of 368±28 mA cmgeo−2 was achieved using a commercial silver catalyst.
Programming Non‐Nucleic Acid Molecules into Computational Nucleic Acid Systems
Authors: Zhang Qiu‐Long , Wang Yang , Wang Liang‐Liang , Xie Fan , Wu Ruo‐Yue , Ma Xu‐Yang , Li Han , Liu Yan , Yao Shunchun , Xu Liang 
Published: November 2022

AbstractNucleic acid (NA) computation has been widely developed in the past years to solve kinds of logic and mathematic issues in both information technologies and biomedical analysis. However, the difficulty to integrate non‐NA molecules limits its power as a universal platform for molecular computation. Here, we report a versatile prototype of hybridized computation integrated with both nucleic acids and non‐NA molecules. Employing the conformationally controlled ligand converters, we demonstrate that non‐NA molecules, including both small molecules and proteins, can be computed as nucleic acid strands to construct the circuitry with increased complexity and scalability, and can be even programmed to solve arithmetical calculations within the computational nucleic acid system. This study opens a new door for molecular computation in which all‐NA circuits can be expanded with integration of various ligands, and meanwhile, ligands can be precisely programmed by the nuclei acid computation.
Synthesis of starch‐based flocculant by multi‐component grafting copolymerization and its application in oily wastewater treatment
Authors: Liu Xiwen , Guo Qiaoxia , Ren Shenyong , Guo Junkang , Wei Chongbin , Chang Jiaxin , Shen Baojian 
Published: November 2022

AbstractThe grafting copolymerization of methacryloxyethyl trimethyl ammonium chloride (DMC), acrylamide (AM) and polyaluminum chloride (PAC) on starch was initiated by KMnO4, HIO4and H2SO4composite system. The modification of starch was combined its best attributes with those of inorganic and organic polymers and therefore enhanced the flocculation effect when it was used as flocculants by increasing the charge neutralization, adsorption bridging and aggregation ability. The main influence factors on oil removal ratio were investigated through orthogonal experimental design, and the optimal preparation conditions were obtained. The grafted copolymer was characterized through a series of physicochemical techniques (i.e., SEC‐MALS,13C MAS NMR,27Al NMR, FTIR, SEM, and TGA and XRD), which indicated the PAC, PAM and PDMC were successfully grafted on the starch.
Novel benzenesulfonamide‐thiouracil conjugates with a flexible N‐ethyl acetamide linker as selective CA IX and CA XII inhibitors
Authors: Abdel‐Mohsen Heba T. , El Kerdawy Ahmed M. , Petreni Andrea , Supuran Claudiu T. 
Published: November 2022

AbstractNovel benzenesulfonamide derivatives linked to diverse functionalized thiouracils through a flexible N‐ethyl acetamide linker were designed and synthesized as carbonic anhydrase (CA) inhibitors. The synthesized candidates demonstrated a potent inhibitory activity against four different CA isoforms in the nanomolar range. Compound 10d showed more than twofold higher potency than the reference AAZ against CA II with Ki of 5.65 and 12 nM, respectively. Moreover, compounds 10d and 20 revealed potent activity against CA IX with Ki of 18.1 and 14.2 nM, respectively. In addition, 10c, 10d, 11b, 11c, and 20 demonstrated high potency against the CA XII isozyme with a Ki range of 4.18–4.8 nM. Most of the synthesized derivatives displayed preferential selectivity toward the CA IX and CA XII isoforms over CA I and CA II. Compounds 11a and 20 exhibited favorable selectivity toward CA IX over CA II with a selectivity index (SI) of 14.36 and 16.62, respectively, and toward CA XII over CA II with SI of 71.01 and 51.19, respectively. Molecular docking simulations showed that the synthesized conjugates adopted comparable binding modes in the CA I, CA II, CA IX, and CA XII isoforms, involving the deep fitting of the sulfonamide moiety in the base of the CA active site via chelation of the Zn2+ ion and H‐bond interaction with the key amino acids Thr199 and/or Thr200. Moreover, the N‐ethyl acetamide flexible linker enables the substituted thiouracils and fused thiouracil tail to achieve multiple interactions with the surrounding hydrophobic and hydrophilic regions.
Deucravacitinib, a Tyrosine Kinase 2 Inhibitor, in Systemic Lupus Erythematosus: A Phase II, Randomized, Double‐Blind, Placebo‐Controlled Trial
Authors: Morand Eric , Pike Marilyn , Merrill Joan T. , van Vollenhoven Ronald , Werth Victoria P. , Hobar Coburn , Delev Nikolay , Shah Vaishali , Sharkey Brian , Wegman Thomas , Catlett Ian , Banerjee Subhashis , Singhal Shalabh 
Published: November 2022

ObjectiveTo assess the efficacy and safety of deucravacitinib, an oral, selective, allosteric inhibitor of TYK2, in a phase II trial in adult patients with active systemic lupus erythematosus (SLE).MethodsAdults with active SLE were enrolled from 162 sites in 17 countries. Patients (n = 363) were randomized 1:1:1:1 to receive deucravacitinib 3 mg twice daily, 6 mg twice daily, 12 mg once daily, or placebo. The primary end point was SLE Responder Index 4 (SRI‐4) response at week 32. Secondary outcomes assessed at week 48 included SRI‐4, British Isles Lupus Assessment Group–based Composite Lupus Assessment (BICLA) response, Cutaneous Lupus Erythematosus Disease Area and Severity Index 50 (CLASI‐50), Lupus Low Disease Activity State (LLDAS), and improvements in active (swollen plus tender), swollen, and tender joint counts.ResultsAt week 32, the percentage of patients achieving SRI‐4 response was 34% with placebo compared to 58% with deucravacitinib 3 mg twice daily (odds ratio [OR] 2.8 [95% confidence interval (95% CI) 1.5, 5.1]; P < 0.001 versus placebo), 50% with 6 mg twice daily (OR 1.9 [95% CI 1.0, 3.4]; P = 0.02 versus placebo), and 45% with 12 mg once daily (OR 1.6 [95% CI 0.8, 2.9]; nominal P = 0.08 versus placebo). Response rates were higher with deucravacitinib treatment for BICLA, CLASI‐50, LLDAS, and joint counts compared to placebo. Rates of adverse events were similar across groups, except higher rates of infections and cutaneous events, including rash and acne, with deucravacitinib treatment. Rates of serious adverse events were comparable, with no deaths, opportunistic infections, tuberculosis infections, major adverse cardiovascular events, or thrombotic events reported.ConclusionDeucravacitinib treatment elicited higher response rates for SRI‐4 and other end points compared with placebo, with an acceptable safety profile, in adult patients with active SLE.image
Functionalized electrodes embedded in nanopores: read‐out enhancement?
Authors: Fyta Maria 
Published: November 2022

AbstractIn this review, functionalized nanogaps embedded in nanopores are discussed in view of their high biosensitivity in detecting biomolecules, their length, type, and sequence. Specific focus is given on nanoelectrodes functionalized with tiny nanometer‐sized diamond‐like particles offering vast functionalization possibilities for gold junction electrodes. This choice of the functionalization, in turn, offers nucleotide‐specific binding possibilities improving the detection signals arising from such functionalized electrodes potentially embedded in a nanopore. The review sheds light onto the use and enhancement of the tunnelling recognition in functionalized nanogaps towards sensing DNA nucleotides and mutation detection, providing important input for a practical realization.
Making and Breaking of C−N Bonds: Applications in the Synthesis of Unsymmetric Tertiary Amines and α‐Amino Carbonyl Derivatives
Authors: Jyoti Roy Vishal , Pathania Vishali , Raha Roy Sudipta 
Published: November 2022

AbstractAn operationally simple process has been developed for the synthesis of unsymmetrical amines and α‐amino carbonyl derivatives in the absence of a catalyst, ligand, oxidant, or any additives. Contrary to known reductive amination methods, this protocol is amenable to substrates containing other reducible groups. This process effectively results in consecutive cleavage and formation of C−N bonds. DFT studies and Hammett analysis provide useful insight into the mechanism. The role of noncovalent interactions as a stabilizing factor have been examined in the protocol. A wide range of alkyl‐bromides have been coupled efficiently with a variety of dimethyl anilines to get unsymmetric tertiary amines with yields up to 90%. This methodology was further extended to the synthesis of α‐amino carbonyl derivatives with yields up to 93%.
Nickel‐Catalyzed Aminocarbonylation of Aryl Iodides with 1 atm CO
Authors: Liu Ning , Wu Xianqing , Qu Jingping , Chen Yifeng 
Published: November 2022

AbstractReported here is a nickel‐catalyzed aminocarbonylation of aromatic iodides with (hetero)aryl anilines and alkyl amines under atmospheric CO pressure. The reaction features with broad substrate scope with excellent functional group tolerance, providing an expedient method for the construction of amide analogues. Notably, amino alcohols can be selectively transformed into the corresponding amides successfully without interfering the hydroxyl group under the current standard conditions.
Predictors of individual differences in minimally verbal peer communication exchanges following peer‐oriented social intervention
Authors: Kedar Maayan , Bauminger‐Zviely Nirit 
Published: November 2022

AbstractSchool‐age children on the autism spectrum who are minimally verbal (MVAS) use a limited repertoire of spontaneous communicative spoken words and reveal large heterogeneity in cognitive functioning. Despite the challenges to form peer social engagement posed by their unique social‐communicative profile, few interventions have targeted peer interactions in the MVAS population. This study explored predictors of individual differences in treatment response among 54 school‐age minimally verbal autistic children (8–16 years) following an RCT “school‐based peer social intervention” (S‐PSI) that compared two peer‐oriented intervention modalities (conversation versus collaboration) versus a waitlisted control group. We examined autistic‐symptom severity, age, verbal and nonverbal IQ, executive functions, and sensory‐processing profile for their contribution to children's ability to form relevant spontaneous communication exchanges with a peer partner. Main findings revealed that larger deficits in sensory‐processing (sensory‐avoidance and sensory low‐registration) and in executive functions contributed to greater growth in “relevant” (i.e., adequately attuned, participatory, reciprocal) communication following both interventions, but not for the waitlisted controls. Additionally, older participants with lower verbal and nonverbal IQ improved communication's relevancy more after the conversation intervention, whereas the collaboration intervention was more beneficial for younger participants. Lower autistic‐symptom severity contributed to larger growth in relevancy for all groups. By identifying individual‐level predictors of spontaneous, attuned, participatory, and reciprocal (i.e., “relevant”) communication exchanges with peers, we optimized S‐PSI personalization for this uniquely nonverbal, heterogeneous MVAS population. These new channels for tailoring peer interventions to better meet individuals' needs may result in reduced social isolation and loneliness and enhanced well‐being.
Validation of case definition algorithms for the ascertainment of congenital anomalies
Authors: Nava de Escalante Yonabeth , Abayomi Aanu , Langlois Sylvie , Ye Xibiao , Erickson Anders , Ngo Henry , Armour Rosemary , Okamoto Reiko , Arbour Laura , Bedard Tanya , Der Kenny , Van Allen Margot , Skarsgard Erik , Lavoie Martin , Henry Bonnie 
Published: November 2022

AbstractBackgroundCongenital anomalies (CA) are one of the leading causes of infant mortality and long‐term disability. Many jurisdictions rely on health administrative data to monitor these conditions. Case definition algorithms can be used to monitor CA; however, validation of these algorithms is needed to understand the strengths and limitations of the data. This study aimed to validate case definition algorithms used in a CA surveillance system in British Columbia (BC), Canada.MethodsA cohort of births between March 2000 and April 2002 in BC was linked to the Health Status Registry (HSR) and the BC Congenital Anomalies Surveillance System (BCCASS) to identify cases and non‐cases of specific anomalies within each surveillance system. Measures of algorithm performance were calculated for each CA using the HSR as the reference standard. Agreement between both databases was calculated using kappa coefficient. The modified Standards for Reporting Diagnostic Accuracy guidelines were used to enhance the quality of the study.ResultsMeasures of algorithm performance varied by condition. Positive predictive value (PPV) ranged between approximately 73%–100%. Sensitivity was lower than PPV for most conditions. Internal congenital anomalies or conditions not easily identifiable at birth had the lowest sensitivity. Specificity and negative predictive value exceeded 99% for all algorithms.ConclusionCase definition algorithms may be used to monitor CA at the population level. Accuracy of algorithms is higher for conditions that are easily identified at birth. Jurisdictions with similar administrative data may benefit from using validated case definitions for CA surveillance as this facilitates cross‐jurisdictional comparison.