bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of percutaneous transluminal angioplasty and surgical revision after intraoperative dilatation with biliary tract probes for arteriovenous fistula stenosis at juxta-anastomosis
Authors: Luo Fenxia , Huang Chunxiang , Yao Guoming , Zhou Jianfang , Lu Xiaoyan 
Published: November 2022

Background Percutaneous transluminal angioplasty (PTA) is widely used for stenosis of vascular access (VA) for hemodialysis. We aimed to evaluate the effectiveness of both PTA and surgical revision after intraoperative dilatation with biliary tract probes for juxta-anastomotic stenosis in autogenous radiocephalic arteriovenous fistulas (RCAVFs). Methods We performed a retrospective analysis of PTA and surgical revision after intraoperative dilatation with biliary tract probes; these were the first interventions after RCAVF establishment in 112 patients with juxta-anastomotic stenosis. Anatomical (number of stenoses) and clinical variables (age and gender of the patient, time of hemodialysis, AVF age, presence of diabetes mellitus, and cause of end-stage renal disease) were reviewed. Technical success, clinical success, and post-intervention primary patency were evaluated. Results Our study enrolled 35 patients in the PTA group and 77 patients in the surgical revision group. Clinical and technical success rates of both groups were 100%. There were no complications, such as bleeding or hematomas. Using the Kaplan–Meier method, the post-intervention primary patency rates at 3, 6, 9, 12, 18, and 24 months in the PTA group were 100%, 94.28%, 77.1%, 60%, 54.29%, and 45.71%, respectively, and those in the surgical revision group were 100%, 94.81%, 92.2%, 90.91%, 81.82%, and 76.62%, respectively. The post-intervention primary patency rates at 9–24 months in the surgical revision group were significantly higher than those in the PTA group ( χ2 = 19.04, p < 0.0001). Conclusion The post-intervention long-term primary patency rate of surgical revision after intraoperative dilatation with biliary tract probes is higher than that of PTA for the first intervention of patients with juxta-anastomotic stenosis in RCAVFs. The surgical revision method is safe and effective, especially in hospitals that have not yet carried out PTA.
Australian sonographers’ perceptions of patient safety in ultrasound imaging: Part 1 – identifying the main safety concerns, a qualitative study
Authors: McInerney John , Lombardo Paul , Cowling Cynthia , Roberts Simone , Sim Jenny 
Published: November 2022

Introduction: Patient safety has been an undervalued component of quality healthcare but is a challenging area of research. Ultrasound is the most common imaging modality in the world. Research on patient safety in ultrasound is generally focused on bioeffects and safe operation of ultrasound equipment. However, other safety issues exist in practice that warrant consideration. This paper forms the first part of a PhD study exploring patient safety in medical diagnostic ultrasound, beyond the notion of bioeffects. The ultimate aim of the study is to inform the final phase of the research study which will consider the next steps in improving the quality and safety of healthcare experienced by patients. Methods: A qualitative study using semi-structured, one-on-one interviews. A thematic analysis categorised data into codes and generated final themes. Results: A heterogeneous mix of 31 sonographers, who reflected the profile of the profession in Australia, were interviewed between September 2019 and January 2020. Seven themes emerged from the analysis. These were bioeffects, physical safety, workload, reporting, professionalism, intimate examinations and infection control. Conclusion: This study presents a comprehensive analysis of sonographers’ perceptions of patient safety in ultrasound imaging, not previously available in the literature. Consistent with the literature, patient safety in ultrasound tends to be viewed in technical terms through the potential for bioeffects of tissue damage or physical harm to the patient. However, other patient safety issues have emerged, and while not as well recognised, have the potential to negatively impact on patient safety.
Physical therapy intervention versus corticosteroid injection for lateral elbow tendinopathy. Does slow and steady win the race? – A systematic review
Authors: Sharma Shivam , Berwal Prerana , Verma Nishank , Pandey Avaneesh Kumar , Saxena Somya , Gamad Nanda 
Published: November 2022

Background Lateral elbow tendinopathy is one of the most common chronic and degenerative diseases which significantly affects quality of life and the activities of daily living of a person. The following is a systematic review reporting a comparison between physical therapy intervention and corticosteroid injection for the treatment of lateral elbow tendinopathy. Method PubMed, Web of Science, and Embase were searched using headings related to treatment options for Lateral elbow tendinopathy. The following keywords were used: lateral epicondylitis, physical therapy, and corticosteroid injection. Result We descriptively analyzed and reviewed a total of 12 studies including a total of 1253 patients for lateral elbow tendinopathy. The physical therapy intervention included interventions like electrotherapy, manual therapy, and exercise. The studies included had an overall low to unknown risk of bias. Conclusion Our review suggests corticosteroid injection provides beneficial short-term effects and physical therapy interventions provide intermediate to long-term effects, less additional treatment and low recurrence rate in patients with lateral elbow tendinopathy. Although high-quality randomized control trials are required in order to have a better understanding of both intervention types.
May an incidental finding on chest CT be a predictor of access in intensive care unit? Role of hepatic steatosis in patients affected by SARS-CoV-2
Authors: Danna Pietro S.C. , Buoni Giada Francesca , Bor Simone , Coda Carolina , Abruzzese Flavia , Bertoli Matteo , Giaivia Valentina , Airoldi Chiara , Castello Luigi Mario , Saba Luca , Carriero Alessandro 
Published: November 2022

Background: Due to the high prevalence of hepatic steatosis (HS), the aim of the study is to verify the frequency of HS incidentally detected in chest computed tomography (CT) imaging in our population affected by SARS-CoV-2 and to investigate its association with the severity of the infection and outcome in terms of hospitalization. Design and methods: We retrospectively analyzed 500 patients with flu syndrome and clinically suspected of having Sars-CoV-2 infection who underwent unenhanced chest CT and have positive RT-PCR tests for Sars-CoV-2 RNA. Two radiologists both with >5 years of thoracic imaging experience, evaluated the images in consensus, without knowing the RT-PCR results. Liver density was measured by a region of interest (ROI), using a liver attenuation value ≤40 Hounsfield units (HU). Results: On 480 patients, 23.1% (111/480) had an incidental findings of HS on chest CT. The steatosis group, included 83 (74.7%) males and 28 (25.3%) females. Patients with HS were more likely to be hospitalized in the intensive care unit (ICU). On univariate analysis, there is a correlation between probability to be intubate (access in the ICU) and HS: patients with HS are twice as likely to be intubated (OR 2.04, CI 95% 1.11–3.73). Conclusion: Chest CT is an important diagnostic tool for COVID-19 and can provide information about the prognosis of the disease. HS can easily be detected on chest CT taken for the diagnosis of the COVID-19 disease, is an important sign for a poor prognosis and possible predictor of admission in ICU.
Vitamin D Deficiency is Associated with Charcot Neuroarthropathy: A Case-Control Study
Authors: Martinazzi Brandon J. , Lorenz F. Jeffrey , Nam Hannah , Dopke Kelly , Ptasinski Anna , Mansfield Kirsten N. , Kirchner Gregory , Aynardi Michael C. 
Published: November 2022

Category: Diabetes; Trauma; Other Introduction/Purpose: Charcot Neuroarthropathy can be a challenging condition for the foot and ankle surgeon. Prior studies have reported Vitamin D deficiency to be associated with several lower extremity complications. However, the relationship between vitamin D deficiency and Charcot is not well defined. Therefore, the purpose of this study was to determine if patients with Charcot were more likely to be vitamin D deficient than patients with diabetes alone. Methods: A large online database from 2011-2021 was retrospectively queried using CTP and ICD codes. Patients were separated into two groups. Group A consisted of patients with diabetes and Charcot Neuroarthropathy. Group B consisted of patients with only diabetes. Statistical analysis was then run to determine if there was an association between Vitamin D deficiency in patients with Charcot compared to patients with diabetes alone. Demographics including age, sex, and race were also recorded. Results: From 2011-2021, a total of 5,428,806 were identified. Group A consisted of 13,519 patients with a mean age of 59 +- 11.6 years. Of these patients, 60% were male (8,064), 40% were female (5,455), 72% were white (9,725), 14% were Black or African American (1,913), 1% were Asian (89), 13% were unknown (1,730), <1% were American Indian (49), and <1% were Native Hawaiian (13). Group B consisted of 5,415,287 patients with a mean age of 59.6 +- 15.4. Of these patients, 50% were male (2,693,118), 50% were female (2,720,313), <1% were unknown (1,856), 59% were white (3,214,4058), 19% were black or African American (995,514), 3% were Asian (139,732), 19% were unknown (1,035,894), <1% were American Indian (20,681), and <1% were Native Hawaiian (13). Patients with Charcot were more likely to have Vitamin D deficiency than diabetic patients alone (OR: 1.687; 95% CI: 1.616, 1.761). Conclusion: In our cohort, patients with Charcot Neuroarthropathy were more likely to be Vitamin D deficient than patients with diabetes alone. Given that Vitamin D deficiency has been found to be associated with lower extremity complications, further investigation is warranted.
Lateral Column Midfoot Injury: Do They All Need Fixation?
Authors: Mason Lyndon W. , Airey Grace L. , Mangwani Jitendra , Tanaka Hiro , Chapman James , Elbannan Mamdouh M. 
Published: November 2022

Category: Trauma; Midfoot/Forefoot Introduction/Purpose: Research on midfoot injuries have primarily concentrated on the central column and the Lisfranc ligament without amassing evidence on lateral column injuries. Lateral column injuries have historically been treated with Kirschner wire fixation when encountered. Our aim in this study was to analyse lateral column injuries to the midfoot and their treatment. Methods: Setting: Multicentre observational study Methods: Data was retrospectively collected from three centres on surgically treated midfoot fracture dislocations between 2011 and 2021. Radiographs were analysed using departmental PACS. All statistics was performed using SPSS 26. Results: A total of 113 cases were diagnosed as having a lateral column injury out of the 242 cases included. On cross tabulation, there was a significant association with having a central column injury (112/113, p<.001) and 70% of cases also had an additional medial column injury. Of the 113 lateral column injuries which underwent fixation of the central column, only 13 had undergone Kirschner wire fixation of the lateral column. There were no reported loss of lateral column alignment in either the temporary fixation or no fixation groups in this study. Conclusion: Lateral column injury occurs in almost half of midfoot fractures in this study. It rarely occurs alone and is most commonly related to three column injuries. Nevertheless, following stabilisation of the central column, injuries to the lateral column are unlikely to require any further stabilisation with no reported loss of alignment in our study without lateral column fixation.
Tibial Nerve Branches in Relation to the Tarsal Tunnel: A Cadaveric Study
Authors: Mattos Ivan , Ubillus Hugo A. , Campos Gustavo , Soares Sérgio , Azam Mohammad T. , Kennedy John G. 
Published: November 2022

Category: Hindfoot; Ankle Introduction/Purpose: Tarsal tunnel syndrome (TTS) is typically caused by an anatomical variant or mechanical compression of the tibial nerve (TN). It is critical then to understand the anatomy of the TN in relation to the tarsal tunnel to understand this condition more fully. Methods: 40 lower-leg specimens were obtained. Dissection started 20 centimeters proximal to the DellonMcKinnon (DM) line towards the medial aspect of the naviculo-cuneiform joint distally. Anteriorly, dissection began at the tibio-talar medial gutter until the medial aspect of the Achilles tendon posteriorly. The plantar aspect extended from medial to lateral within the parameters previously described, ending at the level of the second metatarsal. Results: The flexor retinaculum had a denser consistency in 22.5% of the cases and the average length was 51.9 mm. The flexor retinaculum as an independent structure was absent and 77.2% of cases as an undistinguished extension of the crural fascia. The lateral plantar nerve (LPN) and abductor digiti minimi (ADM) nerve shared the same origin in 80% of cases, 34.5% bifurcated proximal to the DM line, 31.2% distally and 34.3% at the same level. The medial calcaneal nerve (MCN) emerged proximal to the DM line in 100% of specimens. The medial plantar nerve (MPN) has its origin proximal to the DM line in 95% of cases. Conclusion: The flexor retinaculum is an extension of the crural fascia and not an independent structure. The LPN and ADM have the same origin in most cases and this presents as an important finding that must be studied in detail for clinical correlations between the motor ADM and sensory LPN affections. Finally, the branches of the MCN and MPN are the most constant in their distribution and proximal origin in relation to the DellonMcKinnon line.
Hallux Valgus Multiplanar Correction Surgery Through a Minimally Invasive Technique: Our First 100 Patients Experience
Authors: Mocoçain Mac-iver Pablo E. , Elgueta Stephane , Díaz Andres Keller , Radkievich Ruben D. , Valderrama Carlos 
Published: November 2022

Category: Midfoot/Forefoot; Bunion Introduction/Purpose: Recently, minimally invasive surgery for hallux valgus correction has regained popularity. The minimally invasive Chevron and Akin (MICA), has been proved to be as satisfactory for patients as conventional open techniques. However, due to its design, it is difficult to correct the coronal plane malalignment, which could lead to the recurrence of the deformity. Instead, a Bösch-type osteotomy allows multiplanar correction, and with an upgrade in its fixation we can create a stable third- generation percutaneous osteotomy. We report our first 100 patients results using the minimally invasive Bösch and Akin osteotomy (MIBA). Methods: This was a prospective case series of our first 100 patients (137 feet) undergoing MIBA procedure. Outcome measures included the Manchester-Oxford Foot Questionnaire (MOXFQ), the AOFAS Forefoot Score, and the visual analog scale (VAS) for pain assessment. There was also a significant improvement in all radiographic parameters (p < 0.05). Mean HVA decreased from 30.5° to 7.8°, mean IMA decreased from 13° to 4.5°, and the mean DMAA decreased from 13.8° to 4.0° (p<0.05). All complications and emitted radiation dosage were reported as well. Results: At 12 months MOXFQ and AOFAS improved from 57.3 to 0.73 (p=0.00) and 45.2 to 99.2 (p=0.00), respectively. The mean preoperative VAS was 4.6, and improved during the first week to 1.3 (p<0.05). There was also a significant improvement in all radiographic parameters. We had three significant and 13 minor complications. Conclusion: The MIBA procedure is a safe and effective option to achieve a multiplanar hallux valgus correction.
Pohlite, a new lead iodate hydroxide chloride from Sierra Gorda, Chile
Authors: Kampf Anthony R. , Harlow George E. , Ma Chi 
Published: November 2022

AbstractThe new mineral pohlite (IMA2022–043), Pb7(IO3)(OH)4Cl9, was found at La Compania mine, Sierra Gorda, Antofagasta Province, Antofagasta, Chile, where it occurs in cavities in an oxidised portion of a quartz vein in association with massive aragonite and anhydrite. Pohlite crystals are transparent, colourless to pale grey blades, up to 4 mm in length. The mineral has a white streak, adamantine lustre and is nonfluorescent. It is brittle with irregular, conchoidal fracture. The Mohs hardness is ~2½ and it has no cleavage. The calculated density is 5.838(2) g cm–3. Optically, the mineral is biaxial (+) with α < 2.01(est.), β = 2.02 (calc.), γ = 2.05 (calc.); 2V = 60(5)°; moderate r > v dispersion; orientation: Y∧a ≈ 20°, Z∧b ≈ 30°; and is nonpleochroic. The Raman spectrum exhibits bands consistent with IO3– and O–H. Electron microprobe analysis provided the empirical formula Pb6.74I1.00Cl9.29O6.71H4.23. The five strongest powder X-ray diffraction lines are [dobs Å(I)(hkl)]: 3.818(91)(023, 122, 1$\bar{2}$1), 3.674(85)($\bar{1}\bar{2}$1, $\bar{1}$22, 200, 104), 3.399(47)($\bar{2}$10, 210, $\bar{1}$04), 2.378(100)(302, 041, $\bar{2}$24) and 1.9943(45)(multiple). Pohlite is triclinic, P$\bar{1}$, a = 7.3366(5), b = 9.5130(9), c = 16.2434(15) Å, α = 81.592(7), β = 84.955(7), γ = 89.565(6)°, V = 1117.13(17) Å3 and Z = 2. The structure of pohlite (R1 = 0.0328 for 3394 I > 2σI) contains two types of clusters, a [Pb4(OH)3]5+ cluster formed by short Pb–O bonds and a [Pb3(OH)(IO3)]28+ ‘double cluster’ formed by short I–O bonds and short- to medium-length Pb–O bonds. Long Pb–Cl and I–Cl bonds link the clusters together in three dimensions.
Identification of the cuproptosis-related molecular subtypes and an immunotherapy prognostic model in hepatocellular carcinoma
Authors: Zhang Li , Xu Jingwei , Chu Xiufeng , Zhang Hongqiao , Yao Xueyuan , Zhang Jian , Guo Yanwei 
Published: November 2022

Abstract
Background
Cuproptosis, a newly discovered mode of cell death, has been less studied in hepatocellular carcinoma (HCC). Exploring the molecular characteristics of different subtypes of HCC based on cuproptosis-related genes (CRGs) is meaningful to HCC. In addition, immunotherapy plays a pivotal role in treating HCC. Exploring the sensitivity of immunotherapy and building predictive models are critical for HCC.

Methods
The 357 HCC samples from the TCGA database were classified into three subtypes, Cluster 1, Cluster 2, and Cluster 3, based on the expression levels of ten CRGs genes using consensus clustering. Six machine learning algorithms were used to build models that identified the three subtypes. The molecular features of the three subtypes were analyzed and compared from some perspectives. Moreover, based on the differentially expressed genes (DEGs) between Cluster 1 and Cluster 3, a prognostic scoring model was constructed using LASSO regression and Cox regression, and the scoring model was used to predict the efficacy of immunotherapy in the IMvigor210 cohort.

Results
Cluster 3 had the worst overall survival compared to Cluster 1 and Cluster 2 (P = 0.0048). The AUC of the Catboost model used to identify Cluster 3 was 0.959. Cluster 3 was significantly different from the other two subtypes in gene mutation, tumor mutation burden, tumor microenvironment, the expression of immune checkpoint inhibitor genes and N6-methyladenosine regulatory genes, and the sensitivity to sorafenib. We believe Cluster 3 is more sensitive to immunotherapy from the above analysis results. Therefore, based on the DEGs between Cluster 1 and Cluster 3, we obtained a 7-gene scoring prognostic model, which achieved meaningful results in predicting immunotherapy efficacy in the IMvigor210 cohort (P = 0.013).

Conclusions
Our study provides new ideas for molecular characterization and immunotherapy of HCC from machine learning and bioinformatics. Moreover, we successfully constructed a prognostic model of immunotherapy.
Albumin alleviated esketamine-induced neuronal apoptosis of rat retina through downregulation of Zn2+-dependent matrix metalloproteinase 9 during the early development
Authors: Zhang Kan , Ma Ruijing , Feng Luping , Liu Peiwen , Cai Shuang , Tong Chaoyang , Zheng Jijian 
Published: November 2022

Abstract
Aims
Esketamine upregulates Zn2+-dependent matrix metalloproteinase 9 (MMP9) and increases the neuronal apoptosis in retinal ganglion cell layer during the early development. We aimed to test whether albumin can alleviate esketamine-induced apoptosis through downregulating Zn2+-dependent MMP9.

Methods
We investigate the role of Zn2+ in esketamine-induced neuronal apoptosis by immunofluorescence. MMP9 protein expression and enzyme activity were investigated by zymography in situ., western blot and immunofluorescence. Whole-mount retinas from P7 Sprague-Dawley rats were used.

Results
We demonstrated that esketamine exposure increased Zn2+ in the retinal GCL during the early development. Zn2+-dependent MMP9 expression and enzyme activity up-regulated, which eventually aggravated apoptosis. Albumin effectively down-regulated MMP9 expression and activity via binding of free zinc, ultimately protected neurons from apoptosis. Meanwhile albumin treatment promoted activated microglia into multi-nucleated macrophagocytes and decreased the inflammation.

Conclusion
Albumin alleviates esketamine-induced neuronal apoptosis through decreasing Zn2+ accumulation in GCL and downregulating Zn2+-dependent MMP9.
Opioid-reduced anesthesia based on esketamine in gynecological day surgery: a randomized double-blind controlled study
Authors: Zhu Teng , Zhao Xiaoyong , Sun Meiyan , An Yan , Kong Wenwen , Ji Fanceng , Wang Guizhi 
Published: November 2022

Abstract
Background
Opioid-reduced anesthesia may accelerate postoperative rehabilitation by reducing opioid-related side effects. The objective was to investigate the feasibility of opioid-reduced general anesthesia based on esketamine and to observe postoperative nausea and vomiting (PONV), postoperative pain, hemodynamics and other adverse reactions in gynecological day surgery compared with the traditional opioid-based anesthesia program.

Method
This study was conducted as a prospective parallel-group randomized controlled trial. A total of 141 adult women undergoing gynecological day surgery were included. Patients were randomly assigned to receive traditional opioid-based anesthesia (Group C) with alfentanil, or opioid-reduced anesthesia (a moderate-opioid group (Group MO) and low-opioid group (Group LO) with esketamine and alfentanil). For anesthesia induction, the three groups received 20, 20, 10 μg/kg alfentanil respectively and Group LO received an additional 0.2 mg/kg esketamine. For maintenance of anesthesia, the patients in Group C received 40 μg/kg/h alfentanil, and those in Group MO and Group LO received 0.5 mg/kg/h esketamine.

Results
Patients in the three groups had comparable clinical and surgical data. A total of 33.3% of patients in Group C, 18.4% of patients in Group MO and 43.2% of patients in Group LO met the primary endpoint (p = 0.033), and the incidence of nausea within 24 hours after surgery in Group MO was lower than in Group LO (p < 0.05). The extubation time, median length of stay in the hospital after surgery and visual analog scale (VAS) of postoperative pain were equivalent in the three groups. The frequencies of adverse hemodynamic events in the MO 1(0, 2) and LO 0(0, 1) groups were significantly decreased (p < 0.05). Compared with Group C, the median length of stay in the postanesthesia care unit (PACU) in Group LO was increased, 60.0 (36.25, 88.75) vs. 42.5 (25, 73.75) minutes (p < 0.05).

Conclusions
Opioid-reduced anesthesia based on esketamine is feasible and provides effective analgesia for patients. Esketamine provided a positive analgesic effect and the opioid-reduced groups showed more stable hemodynamics. However, less or no use of opioids did not result in a more comfortable prognosis.

Trial registration
This study was registered at Chictr.org.cn (NO. ChiCTR2100053153); November 13, 2021.