bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interaction analysis of FTO and IRX3 genes with obesity and related metabolic disorders in an admixed Latin American population: a possible risk increases of body weight excess
Authors: Ruiz Díaz María Stephany , Mena-Yi Diana , Gómez- Camargo Doris , Mora-García Gustavo José 
Published: November 2022

Background:
Fat Mass and Obesity-related (FTO) has been one of the genes consistently related to common obesity. Single nucleotide polymorphisms (SNPs) in FTO have been linked with the IRX3 gene.
Aim:
This study was designed by testing the hypothesis that: i) common SNPs in FTO and IRX3 are associated with obesity and related disorders; ii) there is significant linkage disequilibrium between both genes.
Methods:
A cross-sectional study was carried out on the Colombian Caribbean Coast. Anthropometric and biochemical variables were measured, and obesity and metabolic disorders were diagnosed. Four SNPs were genotyped: 3 at FTO locus (rs17817449, rs8050136, rs9939609) and one at IRX3 locus (rs3751723). LD between these SNPs was estimated. A logistic regression model was applied to estimate associations.
Results:
A total of 792 subjects were included. FTO and IRX3 were not in LD (D’≤ 0.03; R2≤ 0.03). TT genotype (rs9939609) was found to be associated with waist circumference (p= 0.04; adj-p=0.01), and IRX3 SNP with Body Weight Excess (BWE) (OR= 1.06, adj-p= 0.03). One FTO-IRX3 haplotype was associated with BWE (G-A-A-T, rs17817449-rs8050136-rs9939609-rs3751723; OR= 0.67, p= 0.04). The statistical significance of these relations continued after admixture adjustment for a three-hybrid population (p= 0.03).
Conclusions:
FTO was related to waist circumference, and IRX3 was associated with BWE in Latin American adults. This relation remained statistically significant after performing an adjustment for sex, age, and genetic ancestry. Despite these genes not being in LD, findings of a haplotype involving FTO-IRX3 suggest a gene-gene interaction associated with an increased risk of BWE.
Prevalencia y determinantes de asma en adultos en Quito: un estudio transversal
Authors: Cabrera Angelita , Picado César , Barba Sergio , Fonseca Oscar , Castro Eduardo , García-Marcos Luis , Rodríguez Alejandro 
Published: November 2022

Antecedentes
Aunque en el Ecuador se han realizado varios estudios epidemiológicos de asma en las dos últimas décadas, ninguno de estos ha estimado la prevalencia de asma en poblaciones adultas.
Objetivo
Estimar la prevalencia de síntomas de asma en adultos en Quito e identificar posibles factores asociados.
Métodos
Se realizó un estudio transversal en sujetos mayores a 18 años residentes en la ciudad de Quito-Ecuador. Se aplicó el cuestionario Global Asthma Network para recolectar información sobre síntomas de asma y datos sociodemográficas y de estilo de vida. Para la identificación de factores asociados con asma se utilizó análisis bivariados y multivariados con regresión logística.
Resultados
Un total de 2,476 sujetos respondieron el cuestionario (80.9% mujeres, edad media 40 años). La prevalencia de sibilancias en los últimos 12 meses, asma alguna vez y asma diagnosticado por un médico fue de 6.3%; 1.9% y 1.6%, respectivamente. La prevalencia de rinitis y eczema alguna vez fue de 13.7% y 5.5%. La presencia de moho en el hogar (OR: 2.13; 95%IC: 1.48-3,06; p<0.001), gato en casa (OR: 1.06; 95%IC: 1.06-2.13; p<0.022) y rinitis alguna vez (OR: 3.65; 95%IC: 2.53-5.29; p<0.022) estaban asociados con la presencia de sibilancias en los últimos 12 meses.
Conclusiones
Nuestro estudio muestra que, en comparación con otras ciudades de América Latina, la prevalencia de asma en adultos en Quito es relativamente baja. Junto con la presencia de rinitis, factores relacionados con la calidad de la vivienda están estrechamente ligados con la ocurrencia de asma en poblaciones adultas
El futuro de la rehabilitación post COVID-19
Authors: Torres-Castro Rodrigo 
Published: November 2022

Tras un año y medio de la pandemia, en el que los esfuerzos se han basado fundamentalmente en evitar el colapso de los hospitales y el desarrollo de vacunas innovadoras en tiempo récord, ha aparecido una consecuencia preocupante: las secuelas clínicas entre los supervivientes de esta enfermedad.
A partir del abrumador número de personas infectadas (más de 430 millones de personas hasta febrero de 2022), era posible predecir que un porcentaje significativo de ellas iba a desarrollar secuelas, lo que les dificultaría reintegrarse al trabajo, con sus familias y a la sociedad. Por supuesto, no todas las personas infectadas presentaron secuelas; sin embargo, las probabilidades son significativamente mayores para los afectados por las formas más graves de la enfermedad, como los que sufrieron el síndrome de dificultad respiratoria aguda (SDRA), y particularmente aquellos con comorbilidades, así como los adultos mayores. En los últimos meses, este tema ha sido tan importante que ha aparecido un nuevo concepto relacionado con la persistencia de los síntomas durante más de tres meses: COVID persistente, o "COVID largo". Esta nueva condición nos permite pensar en el COVID persistente como una enfermedad crónica; por lo tanto, la rehabilitación adquiere un papel aún más preponderante por la duración de las secuelas y por los diferentes sistemas involucrados.
Editorial Commentary: Community-acquired pneumonia, comparison of three mortality prediction scores in the emergency department
Authors: Barrera Lena Isabel 
Published: November 2022

Successive measurements of global disease burden have documented that lower respiratory tract infections, including pneumonia, are among the top 10 causes of disability-adjusted life-years, and in 2019, pneumonia was the fourth cause of mortality for all ages. In Colombia, acute respiratory infections are the leading cause of mortality within the group of infectious diseases, 52.3% of the total reported between 2005 and 2019. Notably, the COVID-19 epidemic increased the impact of respiratory tract infections on the global disease burden, with estimates of 18 million excess deaths from January 2020 to December 2021 worldwide.
The assessment of an adult with pneumonia or suspected pneumonia demands the identification of the likelihood of death and hospitalization. Several scales have been constructed to estimate this probability to improve the predictive capacity of clinical evaluation. Among these scales, the CRB-65 and the CURB-65 standout, being the first recommended for use with clinical criteria and the second when laboratory data such as urea nitrogen are available. Additionally, for an individual with sepsis, there have been developed to predict mortality, such as SOFA (Sequential Organ Failure Assessment) and, more recently, the qSOFA(quick SOFA), which has an accurate prediction of mortality in this population.
Hincapié C et al. assessed the CURB-65, CRB-65 and SOFA scales to predict mortality and admission to the intensive care unit in adults with pneumonia in three cohorts of patients admitted in three medium- and high-complexity hospitals in the city of Medellin-Colombia. The study included 1110 patients with suspected pneumonia identified in the emergency department and followed up until discharge and death. The authors found that the highest discrimination capacity, measured by the ROC curve, for the outcome hospitalization in an intensive care unit was 0.61, 0.58, and 0.59 for the CURB-65, CRB-65, and SOFA, respectively. About mortality, the ROC found was 0.66, 0.63, and 0.63 for CURB-65, CRB65, and SOFA, respectively. The calibration was appropriate, that is, the ability to predict mortality and admission to the intensive care unit e for the three scales. Some readers have expressed their disagreement with the possible limited use of the scales, particularly the CURB-65 and the CRB-65, in the evaluation of an adult patient with pneumonia expressed by the authors.
ANDROGEN DEFICIENCY IN AGING MALE AND ISCHEMIC HEART DISEASE
Authors: Шустов С.Б. , Кицышин В.П. , Фролов Д.С. , Макарова А.В. 
Published: November 2022

В статье приведены данные двух собственных исследований, посвященных особенностям течения ишемической болезни сердца у мужчин на фоне возрастного андрогенодефицита. Установлено, что мужчины с коронарной болезнью сердца и возрастным гипогонадизмом характеризуются более выраженными проявлениями ишемии миокарда, дисфункцией вегетативной нервной системы, более тяжелым атеросклерозом коронарных артерий, что в наибольшей степени проявляется в старшей возрастной группе. Предполагается, что возрастной андрогенный дефицит у мужчин среднего возраста с ишемической болезнью сердца может являться компенсаторной реакцией на тяжелое общее заболевание и способствовать лучшим отдаленным результатам реваскуляризации миокарда у них. В то же время, возрастное снижение уровня тестостерона у пожилых мужчин, вероятно, играет иную роль в патогенезе и прогнозе коронарной болезни сердца, нежели у пациентов среднего возраста.
We make a review of our two researches concerning the clinical course of ischemic heart disease in males with age-dependent androgen deficiency. We prove that males suffering from coronary heart disease and age-related hypogonadism tend to have stronger manifestations of myocardial ischemia, dysfunction of vegetative nervous system, more severe atherosclerosis of coronary arteries, which is characteristic for older age. We suppose that androgen deficiency in middle-aged males suffering from ischemic heart disease may be a compensatory response to grave systemic disease and may contribute to better long-term results of myocardial revasculization. At the same time, age-related decline of testosterone in elderly males may play a contrary role in the pathogenesis and forecast of coronary heart disease compared to middle-aged patients.
On Development of Non-Resource Export in Russia: VAT Application
Authors: Якушев Николай Олегович 
Published: November 2022

В статье проводится анализ состояния и развития российского несырьевого экспорта и особенностей применения налоговых льгот при исчислении налога на добавленную стоимость. В результате предложен путь возможного развития несырьевого экспорта в России с учетом политики налогового стимулирования с акцентом на региональное развитие.
We look at the current state and development of Russian non-resource export and features of tax incentives when calculating the value added tax. The research results in suggesting a way of possible development of non-resource export in Russia taking into account tax incentives aimed at regional development.
The Efficiency of Creating Financial Ecosystem within Russian Banks
Authors: Радковская Надежда Петровна , Леонтьев Владимир Евгеньевич , Фомичева Оксана Евгеньевна 
Published: November 2022

В статье рассматриваются вопросы организации процесса создания партнерской экосистемы в российских банках в условиях развития цифровых технологий. Авторами систематизированы ключевые элементы партнерских экосистем ведущих российских банков, обоснованы основные этапы построения экосистем и предложена система финансовых показателей оценки эффективности их функционирования.
The article deals with the organization of the process of creating a partner ecosystem within Russian banks in the context of the development of digital technologies. The authors systematized the key elements of partner ecosystems of leading Russian banks, justified the main stages of ecosystem construction and proposed a system of financial indicators to assess the effectiveness of their functioning.
ANALISIS KINERJA PORTOFOLIO MAGIC FORMULA PADA INDEKS LQ45 DI BURSA EFEK INDONESIA
Authors: Sasmitapura Angga , Michael Michael , Faninda Sandra 
Published: November 2022

The rapid growth of active investors in Indonesia stock market raises awareness on the importance of investors’ skill needed in analyzing and choosing profitable stock. One of the method knows to analyze profitable stock in the market is Magic Formula introduce by Joel Grenblatt -part of value investing. Magic Formula is a method on choosing a profitable stock in a simple way based on combination of both High Earnings Yield and High Return on Capital. The period use in this research is from 2016 – 2020. This research use LQ 45 stock listed in Indonesia Stock Exchange. This qualitative research used secondary data which is analyzed using backtesting simulation. The result of this research shows that Magic Formula’s Stock Portfolio build based on data consist of different number of stock: 15, 20, and 25 stock; combination of both high Earnings Yield and High Return on Capital. The Magic Formula’s Portfolio formed based on the LQ 45 stock has higher aritmathic average return compare to LQ 45 return and even the 15-stock-based portfolio beat the Indonesia Composite Index average return. However on the CAGR rate of return, the calculation show that the return of the Magic Formula Portfolio below the return of Indonesia Composite Index
La comercialización electrónica y la gestión de ventas en el centro artesanal de muebles de madera “Huambaló” de Tungurahua
Authors: Arcos Naranjo Gissela Alexandra , Galarza Torresano Iván Danilo , Arroba Freire Edison Manuel , Sánchez Pérez Vanessa Elizabeth 
Published: November 2022

El presente trabajo investigativo parte de la problemática observada entre los productores de muebles afiliados al Centro Artesanal Humbaló de la provincia de Tungurahua. El objetivo de la investigación fue diagnosticar el porqué de la reducción de ventas en el sector y orientar a una posible solución. El problema se formuló en la siguiente interrogante ¿Cómo mejorar la gestión de ventas de los productores de muebles del Centro Artesanal Huambaló?. Se fundamento científicamente aspectos como comercialización electrónica y ventas, en aspectos metodológicos se utilizó el paradigma cuantitativo, se aplicó la técnica de la encuesta a una población de 41 afiliados activos, el instrumento asociado fue el cuestionario. Entre los principales resultados se obtuvo que no se usa la tecnología como elemento de apoyo en la gestión de ventas, es por ello que se propuso como solución la implementación del comercio electrónico en el centro, para ello se propone crear una tienda virtual y definir políticas de pago, así como de entrega. De la discusión se dedujo que muchas empresas han tomado este camino que implica realmente tener los dos canales de ventas, el tradicional y el electrónico. Finalmente se llegó a la conclusión que una tienda virtual sirve como medio de promoción que amplía los segmentos de mercado y con ello se espera potencializar las ventas de los emprendedores.
A Study of the Background of the Divine Title the “Lord of Spirits” in the Parables of Enoch
Authors: Litvinau Fiodar 
Published: November 2022

Abstract
The aim of the present article is twofold. The first task is to provide a survey of the parallels to the title “Lord of spirits” in the Parables of Enoch (1 En. 37–71) to understand the background of the divine epithet. The studied parallels include titles in the Ancient Near Eastern literature, Biblical and Early Jewish texts, including Dead Sea Scrolls, magical compositions, and Christian texts (New Testament, Patristic and liturgical texts). The second task is to analyze the concept of “spirit” and its cognates in 1 Enoch to provide some clues to the function of the epithet within the composition. The survey aims to demonstrate that a generally accepted interpretation that associates the “spirits” with “angels” should not be overemphasized, since the basic meaning of the title “Lord of spirits” was to indicate God’s authority over human spirits.
DIGITAL TRANSFORMATION OF CYBER SECURITY AT THE MICRO-LEVEL UNDER MARTIAL STATUS
Authors: Kraus Kateryna , Kraus Nataliia , Shtepa Olena 
Published: November 2022

The article describes the possible transformational processes of cybersecurity of business entities in martial law. Authors argue that the security criteria of modern digital entrepreneurship include the following mandatory facts: data must always be encrypted during storage and transmission; encryption must take place at the client level; only the client should have access to the encryption keys; actual data should not be transmitted through open mail channels; the company must control the storage of encrypted information and access keys to it.
A number of current external and internal threats to doing business are listed, including network intrusion, loss of devices with saved passwords, and encryption viruses. Main tasks of enterprises in terms of cybersecurity, namely: identification of potential threats to cybersecurity of enterprises and vulnerabilities; cyber incident prevention; neutralization or minimization of threats to information security of the enterprise.
Authors consider the impact of the information security management system ISO / IEC 27001: 2013 on the work of organizations. It has been found that this system provides an opportunity to implement best practices to improve data protection and eliminate the threat of security breaches of information systems.
The article focuses on the fact that in the framework of cybersecurity in martial law and in the further digitization of activities at the micro level, the basic and priority tasks should be mainly new quality of production processes of technological laboratories: planning work in accordance with requirements industry standards, guidelines and best practices; sampling into the system by assigning it a specific identifier; calculation of results and their design.
Entrepreneurial practice shows that, for example, Ramsomware is the most common threat in the implementation of business processes. Ramsomware is divided into two main types – cryptographers (“cryptoransomware”) and blockers (blockers –“blockers”). Encryptors, when they get to the main computer of the enterprise, encrypt valuable files such as documents, photos, databases. Ramsomware’s business threats include, for example, temporary data loss, which can completely disrupt critical business processes; constant data losses, leading to a decline in the company’s competitiveness, reduced sales revenue in the long run, disrupted continuous access to data.
Authors of the article came to the conclusion that in the light of such criminal cyberattacks, of course, it is logical to develop various types of protection in order to protect data from their interception. This protection must be: invisible to the naked eye; have a secure mail channel; e-mail certificate; e-mail safe; e-mail shredder; cybersecurity center; encryption of letters and attachments; protected view.
MAIN CHARACTERISTICS OF THE CONCEPT OF LOGISTICS AND SUPPLY CHAIN MANAGEMENT SYSTEMS
Authors: Reznik Nadiia , Rudenko Serhii , Pylypchuk Kateryna 
Published: November 2022

Despite the more than two-thousand-year history of logistics, its general problem still exists – the problem of an unsatisfactory level of logistics theory, misunderstanding of the true meaning of logistics. This is manifested in different understanding of logistics in different historical eras; even in one era, there are different understandings of logistics by different authors. And as a result, the low efficiency of logistics practice due to unnecessary actions not related to logistics itself. Therefore, the costs of such logistics, especially for small enterprises, may exceed the results of using the logistics itself. The problem of determining the true meaning of logistics is becoming urgent.
The article examines the concept of logistics, characterizes its essence, analyses the levels of logistics systems, their use in the process of international cooperation. It is shown that the effective functioning of logistics systems and the improvement of the global logistics infrastructure significantly affect the development of international cooperation.
The article highlights the economic essence and significance of logistics. It was determined that the correct functioning and correct interaction of structural elements of logistics processes at the enterprise will contribute to increasing the effectiveness of management decisions. Domestic and foreign definitions of the term «logistics» are analysed. General aspects of the modern understanding of logistics are highlighted. It was determined that logistics allows you to control all processes where savings can be made.
The classification of logistics is presented. The integration of logistics with the main spheres of the enterprise is shown. The article presents a study of modern trends and prospects for the development of the logistics services market in Ukraine, factors that hold back the development of the logistics market in our country, and also analyses the position of Ukraine in the global ranking of logistics efficiency and draws conclusions about the priority directions for its improvement.
To achieve the goal, the following general scientific and special research methods and techniques were used in the work: comparative analysis of scientific literature and information sources based on methods of comparison, systematization and generalization; generalization of analysis results and logical generation of conclusions.
Power Assist Rehabilitation Robot and Motion Intention Estimation
Authors: Adeola-Bello Zulikha Ayomikun , Azlan Norsinnira Zainul 
Published: November 2022

This article attempts to review papers on power assist rehabilitation robots, human motion intention, control laws, and estimation of power assist rehabilitation robots based on human motion intention in recent years. This paper presents the various ways in which human motion intention in rehabilitation can be estimated. This paper also elaborates on the control laws for the estimation of motion intention of the power assist rehabilitation robot. From the review, it has been found that the motion intention estimation method includes: Artificial Intelligence-based motion intention and Model-based motion intention estimation. The controllers include hybrid force/position control, EMG control, and adaptive control. Furthermore, Artificial Intelligence based motion intention estimation can be subdivided into Electromyography (EMG), Surface Electromyography (SEMG), Extreme Learning Machine (ELM), and Electromyography-based Admittance Control (EAC). Also, Model-based motion intention estimation can be subdivided into Impedance and Admittance control interaction. Having reviewed several papers, EAC and ELM are proposed for efficient motion intention estimation under artificial-based motion intention. In future works, Impedance and Admittance control methods are suggested under model-based motion intention for efficient estimation of motion intention of power assist rehabilitation robot. In addition, hybrid force/position control and adaptive control are suggested for the selection of control laws. The findings of this review paper can be used for developing an efficient power assist rehabilitation robot with motion intention to aid people with lower or upper limb impairment.