bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enantioselective Hydroxylation of Dihydrosilanes to Si‐Chiral Silanols Catalyzed by In Situ Generated Copper(II) Species
Authors: Yang Wu , Liu Lin , Guo Jiandong , Wang Shou‐Guo , Zhang Jia‐Yong , Fan Li‐Wen , Tian Yu , Wang Li‐Lei , Luan Cheng , Li Zhong‐Liang , He Chuan , Wang Xiaotai , Gu Qiang‐Shuai , Liu Xin‐Yuan 
Published: June 2022

AbstractCatalytic enantioselective hydroxylation of prochiral dihydrosilanes with water is expected to be a highly efficient way to access Si‐chiral silanols, yet has remained unknown up to date. Herein, we describe a strategy for realizing this reaction: using an alkyl bromide as a single‐electron transfer (SET) oxidant for invoking CuII species and chiral multidentate anionic N,N,P‐ligands for effective enantiocontrol. The reaction readily provides a broad range of Si‐chiral silanols with high enantioselectivity and excellent functional group compatibility. In addition, we manifest the synthetic potential by establishing two synthetic schemes for transforming the obtained products into Si‐chiral compounds with high structural diversity. Our preliminary mechanistic studies support a mechanism involving SET for recruiting chiral CuII species as the active catalyst and its subsequent σ‐metathesis with dihydrosilanes.
Rechargeable Aqueous Mn‐Metal Battery Enabled by Inorganic–Organic Interfaces
Authors: Yang Qi , Qu Xiaofeng , Cui Huilin , He Xincheng , Shao Yuan , Zhang Yong , Guo Xun , Chen Ao , Chen Ze , Zhang Rong , Kong Duanyang , Shi Zhicong , Liu Jun , Qiu Jieshan , Zhi Chunyi 
Published: June 2022

AbstractAqueous batteries that use metal anodes exhibit maximum anodic capacity, whereas the energy density is still unsatisfactory partially due to the high redox potential of the metal anode. Current metal anodes are plagued by the dilemma that the redox potential of Zn is not low enough, whereas Al, Mg, and others with excessively low redox potential cannot work properly in aqueous electrolytes. Mn metal with a suitably low redox potential is a promising candidate, which was rarely explored before. Here, we report a rechargeable aqueous Mn‐metal battery enabled by a well‐designed electrolyte and robust inorganic–organic interfaces. The inorganic Sn‐based interface with a bottom‐up microstructure was constructed to preliminarily suppress water decomposition. With this bubble‐free interface, the organic interface can be formed via an esterification reaction of sucrose triggered by acyl chloride in the electrolyte, generating a dense physical shield that isolates water while permitting Mn2+ diffusion. Hence, a Mn symmetric cell achieves a superior plating/stripping stability for 200 hours, and a Mn||V2O5 battery maintains approximately 100 % capacity after 200 cycles. Moreover, the Mn||V2O5 battery realizes a much higher output voltage than that of the Zn||V2O5 battery, evidencing the possibility of increasing the energy density through using a Mn anode. This work develops a systematic strategy to stabilize a Mn‐metal anode for Mn‐metal batteries, opening a new door towards enhanced voltage of aqueous batteries.
Tailored Multivalent Targeting of Siglecs with Photosensitizing Liposome Nanocarriers
Authors: Almeida‐Marrero Verónica , Bethlehem Fleur , Longo Sara , Bertolino M. Candelaria , Torres Tomás , Huskens Jurriaan , de la Escosura Andrés 
Published: June 2022

AbstractThe modification of surfaces with multiple ligands allows the formation of platforms for the study of multivalency in diverse processes. Herein we use this approach for the implementation of a photosensitizer (PS)‐nanocarrier system that binds efficiently to siglec‐10, a member of the CD33 family of siglecs (sialic acid (SA)‐binding immunoglobulin‐like lectins). In particular, a zinc phthalocyanine derivative bearing three SA moieties (PcSA) has been incorporated in the membrane of small unilamellar vesicles (SUVs), retaining its photophysical properties upon insertion into the SUV's membrane. The interaction of these biohybrid systems with human siglec‐10‐displaying supported lipid bilayers (SLBs) has shown the occurrence of weakly multivalent, superselective interactions between vesicle and SLB. The SLB therefore acts as an excellent cell membrane mimic, while the binding with PS‐loaded SUVs shows the potential for targeting siglec‐expressing cells with photosensitizing nanocarriers.
A phosphorus/silicon/triazine‐containing flame retardant towards flame retardancy and mechanical properties of epoxy resin
Authors: Hou Zhuang , Cai Haopeng , Li Chuan , Li Bolun , Wang Huihuan 
Published: June 2022

AbstractA phosphorous/silicon/triazine‐containing flame retardant named DTD is synthesized and provides epoxy resin with enhanced flame retardancy and mechanical properties simultaneously. The modified epoxy with the DTD content of 18.1 wt% shows excellent flame retardancy, manifested in the limited oxygen index (LOI) value of 36.6% with UL‐94 V‐0 rating obtained. In the cone calorimeter test, its peak heat release rate (PHRR), total heat release (THR) and average effective heat of combustion (av‐EHC) are reduced by 43.7%, 45.0%, and 38.1% compared with neat epoxy resin, respectively. Besides, DTD exhibits a good charring capability, indicated by observation of an expanded char layer structure and the 160.3% increment in char residue after the cone calorimeter test. The mode of action of DTD is explained by the analysis of char residue and the pyrolysis behavior in the gas phase. In addition, DTD has good compatibility with epoxy resin, confirmed by single spike of tan delta and similar half‐peak width in dynamic mechanical analysis. While improving the flame retardancy, DTD also enhances the mechanical properties of epoxy resin. With 8.8 wt% of DTD content, the modified epoxy resin possesses desirable mechanical properties, with 36.0% and 18.9% increase in tensile strength and flexural strength, respectively.
Dielectric properties and dielectric relaxation process of polymethylphenylsiloxane/silicon dioxide nanocomposites
Authors: Yu Yan , Zhao Yan , Huang Bin , Ji Yanwei , Zhao Yunfeng , Zhang Zhijie , Fei Hua‐Feng 
Published: June 2022

AbstractIn recent years, polysiloxane dielectric elastomers (DEs) have attracted extensive attention, but their low dielectric constant and electrical breakdown strength are the main factors that limit their wide application. In this work, we report the effects that a high content of hydrophobic silica has on the dielectric properties and dielectric relaxation behavior of polymethylphenylsiloxane (PMPS). Introducing a high content of hydrophobic silica into PMPS composites increased the dielectric constant of PMPS composites from 3.11 to 3.70 and the breakdown strength of PMPS composites from 35.31 to 42.66 kv/mm. The high content of hydrophobic silica is beneficial for restraining or delaying the occurrence of direct current (DC) conductivity and for effectively reducing the dielectric loss of composites in high temperature and low‐frequency regions. The high content of hydrophobic silica also produces interfacial polarization in the composites, and this increases the dielectric constant and dielectric loss in the high frequency and low‐temperature regions. The dielectric relaxation behavior of PMPS composites was studied in detail using broadband dielectric spectroscopy (BDS) and thermally stimulated depolarization current (TSDC) to better understand the effect of hydrophobic silica on dielectric properties. This work opens a new way to design and prepare polysiloxane‐based materials that have a high dielectric constant, low dielectric loss, and high breakdown strength.
Recent Advances towards the Synthesis and Material Applications of Indoloindoles
Authors: Paul Dipankar , John Jubi 
Published: June 2022

AbstractAn important class of N‐heteroacenes is indoloindoles which are air‐stable, electron‐rich and possess many tuneable properties. Initially, indoloindoles were explored for potential biological applications but current interest is based on their performance as photovoltaic materials. With growing applications of indoloindoles across multiple facets as organic functional materials, the need for efficient methods to synthesize and functionalize indoloindoles has taken a centre stage. Over the years, synthetic routes leading to indoloindoles have evolved from multistep protocols to one‐pot multicomponent synthesis. Present literature boasts of a variety of reports that employ metals such as Cu, Ru, Rh, Pd, or Au to mediate the reaction towards indoloindoles. As alternatives to such metal‐mediated methods, researchers have also developed metal‐free and catalyst‐free conditions. Indoloindoles, which are fundamentally fused‐indoles, are often synthesized by transforming indole derivatives but methods that employ anilines or arynes as the starting substrates are equally abundant. The present review highlights the rich diversity and versatility of recent literature for the synthesis of indolo[3,2‐b]indoles, indolo[2,3‐b]indoles, indolo[7,6‐g]indoles, and indolo[5,4‐e]indoles. This review discusses protocols that were explicitly designed to obtain the above‐mentioned indoloindoles and also explores several other methods that can be adapted to access said heteroacenes. Available mechanistic details pertaining to novel transformations have been detailed for the readers. Various applications where indoloindoles function as organic light‐emitting diodes, organic field‐effect transistors, solar cells, etc. have also been delved into before concluding with an outlook on future research.
X4S – Klimaneutral Wohnen und Arbeiten in der Stadt
Authors: Gerber Andreas , Löhr Felix , Lewandowski Mari , Frühschütz Lena , Weitschies Rainer 
Published: June 2022

AbstractDas Team X4S der Hochschule Biberach entwickelt und plant für den SDE 21/22 eine Aufstockung mit vier Geschossen in Holzbauweise auf ein zweigeschossiges Bestandsgebäude im Quartier Wuppertal‐Mirke. Ziele des Beitrags ist die Schaffung von neuem Wohnraum und Büroflächen. Solarenergienutzung in der Fassade und auf dem Dach soll die C02‐neutrale Betrieb des Gebäudes aus Bestand und Aufstockung ermöglichen. Die Baukonstruktion der Aufstockung ist auf Langlebigkeit, Trennbarkeit, Wiederverwertbarkeit der verwendeten Roh‐ und Baustoffe ausgerichtet. In diesem Betrag werden die Konstruktion der Gebäudehülle und die bauphysikalischen Eigenschaften des Gebäudes mit einem Fokus auf ihre Bedeutung für das Energiesystem vorgestellt.
Synthesis of selenated γ‐lactones via photoredox‐catalyzed selenylation and ring closure of alkenoic acids with diselenides
Authors: Park Jiwoo , Kim Dae Young 
Published: June 2022

AbstractA photoredox‐catalyzed selenylation and ring closure sequences of alkenoic acid derivatives are achieved. This transformation is efficiently accelerated using an inexpensive Rhodamine 6G as an organophotocatalyst under visible light irradiation. The present method affords efficient and practical access to structurally diverse selenated γ‐lactones in moderate to high yields.
An observation study of urinary biomarker exploratory in Alzheimer's disease using high‐resolution mass spectrometry
Authors: Zhang Qun , Wu Shuo , Liu Xinru , Yang Jun , Dong Xin , Zhou Yinge , Chen Junjie , Li Yamei , Yang Jingzhi 
Published: June 2022

AbstractAlzheimer's disease (AD) is regarded as a progressive neurodegenerative dementia, characterized by degeneration of distinct neuronal populations. A case–control study was carried out using high‐resolution mass spectrometry to explore AD‐associated urinary metabolic biomarkers from 30 AD patients and 30 cognitively normal (CN) individuals. In total, 49 metabolites were determined and validated as known compounds using LC/MS analysis. Using the two‐sample t‐test statistical analysis (P < 0.05), 19 metabolites were shown to be significantly different from AD to CN. A diagnostic model of the receiver operating characteristic curve was constructed with a combination of nine molecules out of 19 metabolites, it yielded a separation with an area under the curve value of 0.976 between the two groups. This study indicated that urinary metabolites showed a significant expression between AD and CN. AD‐related metabolites enable to satisfy the diagnostic power of disease discrimination. In addition, as a noninvasive approach, urine collection is done easily in clinical diagnosis of AD.
Interest in fertility status assessment among young adult survivors of childhood cancer
Authors: Cherven Brooke , Lewis Rebecca Williamson , Pruett Megan , Meacham Lillian , Klosky James L. 
Published: June 2022

AbstractBackgroundCancer survivors who received gonadotoxic treatment are at‐risk for future infertility and may desire a fertility status assessment (FSA), defined as semen analysis for males and consultation with a reproductive specialist for females. The purpose of this study was to describe the proportion of, and factors associated with, interest in FSA among young adult survivors of childhood cancer.MethodsThis retrospective single‐institution review included patients with prior gonadotoxic treatment, aged 18–25 years and >1 year from cancer treatment completion, who received a fertility‐focused discussion during survivorship. Documentation of interest in and completion of FSA, worry about infertility, sociodemographic, and clinical characteristics were abstracted from medical records. Multivariable logistic regression was performed to calculate odds ratios (OR) and 95% confidence intervals (95%CI) for factors associated with interest in FSA.ResultsSurvivors (N = 259) were on average 19.2 ± 1.2 years at their fertility discussion; 55.6% were male and 57.9% non‐Hispanic white. Interest in FSA was reported by 50.7% of males and 46.1% of females. Factors related to interest in FSA for males and females respectively, included worry about infertility (OR 2.40, 95%CI 1.11–5.27, p = 0.026 and OR 4.37, 95%CI 1.71–12.43, p = 0.003) and ≥2 fertility discussions (OR 3.78, 95%CI 1.70–8.75, p = 0.001 and 2.45, 95%CI 1.08–5.67, p = 0.033). Among males, fertility preservation consult/procedure at diagnosis (OR 3.02, 95%CI 1.09–9.04, p = 0.039) and high‐risk for infertility (OR 2.47, 95%CI 1.07–5.87, p = 0.036) were also associated with interest in FSA.ConclusionsCancer survivors are interested in FSA, particularly those who have had repeated fertility‐focused discussions during survivorship care and who report worry about infertility.
Traditional Chinese medicines and capecitabine‐based chemotherapy for colorectal cancer treatment: A meta‐analysis
Authors: Jiang Hui‐Zhong , Jiang Ya‐Li , Yang Bing , Long Feng‐Xi , Yang Zhu , Tang Dong‐Xin 
Published: June 2022

AbstractThis meta‐analysis was conducted to evaluate the efficacy and safety of the addition of Traditional Chinese Medicine (TCMs) to capecitabine‐based regimens for colorectal cancer (CRC) in term of tumor. The eight electronic databases including Cochrane Library, PubMed, Web of Science (WOS), Excerpt Medica Database (Embase), Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Journals (CQVIP), and Wanfang Database were systematically searched for eligible studies from their inception to March 2021. Thirty‐nine randomized controlled trials were involved in this study, and all the data were analyzed by Review Manager 5.3 (Nordic Cochran Centre, Copenhagen, Denmark) and R 4.0.5 software. The meta‐analyses suggested that TCMs in combination with capecitabine‐based regimens increased objective response rate (ORR) in the palliative treatment of CRC (risk ratio [RR], 1.35 [1.17, 1.55],I2 = 0%), disease control rate (DCR) (RR, 1.22 [1.12, 1.32],I2 = 3%), and quality of life (QOL) (RR, 1.71 [1.44, 2.03],I2 = 0%), with decreased risks of myelosuppression, anemia, thrombocytopenia, liver/renal dysfunction, neurotoxicity, nausea/vomiting, neutropenia, diarrhea, leukopenia, improved the peripheral lymphocyte, reduced the expression of tumor markers, and related factors. Further sensitivity analysis of specific plant‐based TCMs found that dangshen, fuling, and gancao had significantly higher contributions to the results of the RR. The results show that capecitabine‐based chemotherapy combined with TCM in the treatment of CRC increases the efficiency of ORR and DCR, reduces chemotherapeutic agents‐associated adverse reactions, and improves their life quality as compared with chemotherapy alone, but further randomized and large sample of studies are needed.
Contemporaneous symptom networks of multidimensional symptom experiences in cancer survivors: A network analysis
Authors: Zhu Zheng , Sun Yanling , Kuang Yi , Yuan Xiaoyi , Gu Haiyan , Zhu Jing , Xing Weijie 
Published: June 2022

AbstractBackgroundSymptom networks can provide empirical evidence for the development of personalized and precise symptom management strategies. However, few studies have explored the symptom networks of multidimensional symptom experiences in cancer survivors. The objectives of this study were to generate symptom networks of multidimensional symptom experiences in cancer survivors and explore the centrality indices and density in these symptom networksMethodsData from 1065 cancer survivors were obtained from the Shanghai CANcer Survivor (SCANS) Report. The MD Anderson Symptom Inventory was used to assess the prevalence and severity of 13 cancer‐related symptoms. We constructed contemporaneous networks with all 13 symptoms after controlling for covariates.ResultsDistress (rs = 9.18, rc = 0.06), sadness (rs = 9.05, rc = 0.06), and lack of appetite (rs = 9.04, rc = 0.06) had the largest values for strength and closeness. The density of the “less than 5 years” network was significantly different from that of the “5–10 years” and “over 10 years” networks (p < 0.001). We found that while fatigue was the most severe symptom in cancer survivorship, the centrality of fatigue was lower than that of the majority of other symptoms.ConclusionOur study demonstrates the need for the assessment of centrality indices and network density as an essential component of cancer care, especially for survivors with <5 years of survivorship. Future studies are warranted to develop dynamic symptom networks and trajectories of centrality indices in longitudinal data to explore causality among symptoms and markers of interventions.
Syringenes M – Q, Eremophilane Sesquiterpenoid Dimers from the Peeled Stems ofSyringa pinnatifolia
Authors: Li Anni , Ma Xiaojing , Zhang Ruifei , Jiao Shungang , Li Weifeng , Gao Xiaoli , Xu Jixuan , Tu Pengfei , Chai Xingyun 
Published: June 2022

AbstractAs a part of systematic studies onSyringa pinnatifolia, a continued phytochemical investigation guided by1H‐NMR and LC/MS data on the ethanol extract afforded five new dimeric eremophilane sesquiterpenoids, namely syringenes M−Q (1–5). These structures were elucidated by extensive analysis of spectroscopic data, including infrared (IR), high‐resolution electrospray ionization mass spectrometry (HR‐ESI‐MS), nuclear magnetic resonance (NMR), quantum‐mechanics‐based computational analysis of NMR chemical shifts, and single‐crystal X‐ray diffraction. Compounds4and5showed inhibitory activities against NO production induced by lipopolysaccharide in RAW264.7 macrophage cells, with IC50values of 5.1 and 9.3 μM, compared to positive control indomethacin (IC5033.6 μM). These dimeric eremophilane sesquiterpenoids may be potential markers for discriminating this species from the genusSyringaand the Oleaceae family.
A novel technique for the percutaneous removal of tricuspid valve vegetations utilizing the Inari Flowtriever System
Authors: Becker Matthew C. , Reddy Siddarth , Miccio Brendan , Pappas Orestis 
Published: June 2022

AbstractRight‐sided infective endocarditis is a common entity for which surgical intervention is frequently high‐risk. Considering its invasive nature, potential complications, and challenging patient population, a less invasive endovascular option is desirable. The previous series have demonstrated the feasibility of percutaneous therapy for tricuspid valve (TV) vegetation utilizing a filter‐based bypass circuit. However, the limited availability of a specialized team, resources, procedural complexity, and large bore sheath size restrict the broad adoption of this technique. The Inari FlowTriever System (Inari Medical) is an endovascular, catheter‐based, aspiration, and mechanical thrombectomy system indicated for the removal of large‐volume venous thrombus and pulmonary emboli. Independent of anesthesia, perfusion, or advanced imaging, this device's characteristics uniquely improve the operator's ability to safely remove unwanted debris from complex anatomy. This report describes the first, utilization of the Inari FlowTriever System for the removal of massive and inoperable TV vegetation.
Selective Oxidation of Olefins to Aldehydes/ Ketones/ Carboxylic Acids with an Efficient and Practical Polyoxometalate‐based Iron Catalyst
Authors: Chang Yalin , Xie Ya , Zhao Chengchun , Ren Jingjing , Su Wei , Zhao Wenshu , Wu Linke , Yu Han 
Published: June 2022

AbstractHerein, we reported the efficient method for synthesis of aldehydes, ketones and carboxylic acids from olefins catalyzed by inorganic‐ligand Fe (III) catalyst, (NH4)3[FeMo6O18(OH)6]. This transformation features sustainable conditions and utilizes commercially available H2O2 as the sole oxidant and CH3CN/ AcOH as the solvent. The simple synthesized catalyst has high efficiency towards the reactions under mild conditions and can be recycled at least six times with keeping stable activity. At the same time, the controllable products in the reaction have the potential for industrial application.
On the Optimization of Nitrogen‐Reduction Electrocatalysts: Breaking Scaling Relation or Catalytic Resonance Theory?
Authors: Exner Kai S. 
Published: June 2022

AbstractElectrochemical nitrogen reduction reaction (NRR) is mainly hampered by two facts. On the one hand, the hydrogen evolution reaction competes with the NRR under cathodic reaction conditions. On the other hand, the sluggish reaction kinetics of the NRR, due to the transfer of six proton‐electron pairs in the reaction mechanism, causes large overpotentials, and thus results in humble intrinsic activity for ammonia formation. Optimization strategies for NRR electrocatalysts are ultimately called for to overcome these issues. While breaking scaling relation is considered as a universal remedy to enhance turnover for any electrocatalytic process, recently, the concept of catalytic resonance theory has been put forth as a second option to obtain reaction rates beyond the limiting Sabatier volcano. Yet, a comparison of these two concepts is missing but urgently needed to comprehend design principles for electrocatalyst optimization on the atomic scale. In the present work, breaking scaling relation and catalytic resonance by programmable catalysis are compared on the example of the NRR over transition‐metal oxides. It is demonstrated that a fine tuning rather than a full breaking of nitrogen‐containing scaling relations is required to enhance electrocatalytic activity of electrocatalysts at the volcano apex. The success of catalytic resonance theory is based on the occurrence of negative scaling correlations whereas in the case of positive scaling correlations, the impact of this approach on the optimization of electrocatalysts strongly depends on the location of the material in the volcano plot. The obtained insight may spur the development of NRR electrocatalysts with enhanced intrinsic activity by following the outlined design principles.