bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacoeconomic analysis of using benralizumab for treatment of severe asthma in inpatient and outpatient settings
Authors: Zhuravleva M. V. , Avdeev S. N. , Gagarina Yu. V. , Marin T. V. 
Published: July 2022

Objective: evaluation of the pharmacoeconomic feasibility of using benralizumab in the form of autoinjector (pen-injector device) in outpatient facilities compared with its use in the form of a syringe in hospital settings for the treatment of severe asthma (SA).Material and methods. The cost minimization and budget impact analysis methods were used. The current practice of treating patients with SA with benralizumab in hospital settings at the expense of compulsory medical insurance funds was compared with the simulated practice. The simulated price was calculated as half patients receiving benralizumab in the hospital transferred to outpatient facilities at the expense of regional funds for 3 years. Direct medical costs included drug cost and outpatient patient monitoring services cost.Results. The direct medical costs associated with benralizumab therapy in outpatient facilities were lower than the costs required for benralizumab therapy in the hospital settings and amounted to 0.99 million rubles versus 1.17 million rubles per one patient per year, respectively. Thus, the use of benralizumab in outpatient facilities leads to savings of 185 thousand rubles (16%). In 2021, 93 patients were prescribed benralizumab in hospital settings. The expansion of the application of benralizumab use in outpatient facilities will lead to a reduction in medical costs in the first year of therapy (when switching 16.7% of patients) by 5.9 million rubles (4,9%). The consistent expansion of the practice of benralizumab use in outpatient facilities over a 3-year horizon (when switching 50% of patients) will lead to a reduction in medical costs by 46.6 million rubles (12.1%).Conclusion. Expansion of benralizumab use in outpatient facilities with a new form of autoinjector (pen-injector device) will lead to savings in medical costs and reduce the burden on the health care system, thus it is economically feasible.
Sectoring Method for Improving Various QoS Parameters of Wireless Sensor Networks to Improve Lifespan of the Network
Authors: Patil Prajakta , Waghole Dr. Dattatray , Deshpande Dr. Vivek , Karykarte Dr. Mandar 
Published: July 2022

The wireless sensor network is set of distributed nodes, which are randomly deployed in sensor field to capture various parameters and send it to receiver station for further analysis and prediction. There are two types of protocols essential for communication. One is MAC protocol and another is routing protocol. Routing protocols are used for finding shortest path between sources to destination. MAC protocols are used for reliable data delivery from source to destination. The design of a reliable wireless sensor network (WSN) must handle the failure of single or many network components, still, because of the deployment of mechanisms to tolerate faults at various levels. the most objective of this paper is to review different existing algorithms proposed by different researchers and merge their work for further study. This paper studies different prototypes and proposed algorithms, and also the objectives of the papers. Also, the paper elaborates on the proposed algorithm within the particular paper together with their objectives. Proposed algorithm is very useful for to reduce heavy congestion over the networks and achieve various parameters of sensor networks.
Real-Time Classification of Anthropogenic Seismic Sources from Distributed Acoustic Sensing Data: Application for Pipeline Monitoring
Authors: Huynh Camille , Hibert Clément , Jestin Camille , Malet Jean-Philippe , Clément Pierre , Lanticq Vincent 
Published: July 2022

Abstract
Distributed Acoustic Sensing (DAS) is an innovative method to record acoustic waves using an optical fiber as a network of sensors. Current DAS devices can monitor up to 50 km of optical fiber and the use of optical repeaters can raise even more this length, while allowing a spatial discretization of the order of a meter. Handling such amount of data is a challenge in terms of data management and data analysis (such as event source identification), more specifically for monitoring applications such as infrastructures or natural hazards. In this work, we propose a processing chain for real-time classification of anthropogenic sources using a combination of Random Forest (RF) and Random Markov Field (RMF). To develop the method, we choose to focus on the application of pipeline monitoring. The algorithm is therefore trained to recognize six classes of seismic sources: pedestrian, impact, backhoe, compactor, leak, and noise. All the sources were triggered and recorded on our own test bench under controlled conditions. The average sensitivity of our processing chain reaches 83% with the use of only RF and achieves 87% in combination with RMF. Classification maps show that the RMF approach can increase the average sensitivity by removing isolated signals. In addition to this improvement in sensitivity, this new approach also permits to identify synchronous events taking place at nearby positions, which is difficult with classical methods.
Waveform Features Strongly Control Subcrater Classification Performance for a Large, Labeled Volcano Infrasound Dataset
Authors: Toney Liam , Fee David , Witsil Alex , Matoza Robin S. 
Published: July 2022

Abstract
Volcano infrasound data contain a wealth of information about eruptive patterns, for which machine learning (ML) is an emerging analysis tool. Although global catalogs of labeled infrasound events exist, the application of supervised ML to local (&lt;15 km) volcano infrasound signals has been limited by a lack of robust labeled datasets. Here, we automatically generate a labeled dataset of &gt;7500 explosions recorded by a five-station infrasound network at the highly active Yasur Volcano, Vanuatu. Explosions are located via backprojection and associated with one of Yasur’s two summit subcraters. We then apply a supervised ML approach to classify the subcrater of origin. When trained and tested on data from the same station, our chosen algorithm is &gt;95% accurate; when training and testing on different stations, accuracy drops to about 75%. The choice of waveform features provided to the algorithm strongly influences classification performance.
Estudio de caso de dos cooperativas de Teruel (España), a partir del cumplimiento de los principios cooperativistas y de su rentabilidad financiera
Authors: Flores Ilhuicatzi Uziel , Medina Conde Ana Laura 
Published: July 2022

La economía social prioriza a la persona antes que, a los rendimientos económicos, dentro de ella se encuentra la cooperativa que es vertebradora del territorio y genera desarrollo local. Por ello, el objetivo general del presente trabajo es realizar un estudio de caso de dos cooperativas de Teruel España, determinando la relación existente entre el cumplimiento de los principios cooperativistas y la generación de rendimientos económicos, a partir del análisis de sus estados financieros. Los resultados demuestran que ambas cumplen con la mayoría de los principios cooperativos y que son rentables, solventes, tienen liquidez y no están apalancadas financieramente sus operaciones como rotación de activos netos, existencias, cobertura de intereses, y sus carteras de cuentas por cobrar y cuentas por pagar son aceptables, además la estructura de solvencia en promedio del año 2016 a 2018 para Arcoíris es del 20% y para Cereales Teruel del 60%.
Recibido: 24 septiembre 2021Aceptado: 23 marzo 2022
THE VALUES OF ISLAMIC CONDUCT IN THE JAVANESE NOVEL BY TULUS SETIYADI
Authors: Sulaksono Djoko , Hasanah Eryneta Nurul 
Published: July 2022

Javanese novel is one of the literary works which is still popular today. It is closely related to the author's background, such as social conditions, education, and religion. Every Javanese novel contains the values of character education or moral values that the author wants to convey to the readers. Thus, as a literary work, it cannot be separated from religion. This study aimed to analyze and describe Islamic moral values in Javanese novels. The data sources of the current research are three Javanese novels by Tulus Setiyadi. It is a descriptive qualitative study with a sociology of literature approach which includes three stages of data analysis: data reduction, data presentation, and conclusion drawing. The results of this study demonstrate that the Javanese novels by Tulus Setiyadi contain Islamic moral values based on the Qur'an and hadith which cover the relationship between human and God, human relationships with fellow humans, and human relationships with oneself. The moral values are expected to imitate and implement by the society in their daily life. It can be used to instil and promote a noble character among society. Novel Jawa adalah salah satu karya sastra yang masih populer hingga saat ini. Novel Jawa berkaitan erat dengan latar belakang pengarang, seperti keadaan sosial masyarakat, pendidikan, maupun agama. Setiap novel Jawa tentu mengandung nilai-nilai pendidikan karakter atau nilai budi pekerti yang ingin disampaikan pengarang kepada pembaca. Dengan demikian, novel Jawa sebagai salah satu karya sastra tidak dapat dipisahkan dari agama. Penelitian ini bertujuan untuk menganalisis dan mendeskripsikan nilai-nilai budi pekerti Islam yang terkandung dalam novel-novel Jawa karya Tulus Setiyadi. Sumber data penelitian ini adalah tiga novel Jawa karya Tulus Setiyadi. Jenis penelitian ini adalah deskriptif kualitatif dengan pendekatan sosiologi sastra yang meliputi tiga tahap analisis data, yaitu reduksi data, sajian data, dan penarikan simpulan. Hasil penelitian menunjukkan bahwa novel-novel Jawa karya Tulus Setiyadi mengandung nilai budi pekerti Islam yang didasarkan pada Alquran dan hadis meliputi hubungan manusia dengan Tuhan, hubungan manusia dengan sesama manusia, dan hubungan manusia dengan diri sendiri. Adanya nilai-nilai budi pekerti dalam novel-novel Jawa karya Tulus Setiyadi diharapkan dapat diteladani dan diimplementasikan oleh masyarakat dalam kehidupan sehari-hari. Hal ini dapat dijadikan sebagai upaya untuk membentuk pribadi yang berakhlak mulia.
Implementasi Metode Pembelajaran Kooperatif Tipe STAD dalam Meningkatkan Sikap Toleransi dan Hasil Belajar Siswa
Authors: Mufidah Nastiti , Kurniawan Abdul Fatah 
Published: July 2022

The purpose of this article is to find out how the role of the implementation of the STAD (Student Teams Achievements Divisions) cooperative learning method is to increase student tolerance. And whether the STAD Cooperative learning method can improve student learning outcomes, especially in Social Science subjects. This research method is Classroom Action Research (CAR). This research consisted of two cycles, and each cycle consisted of four stages, namely: planning, implementation, observation, and reflection. The subjects of this study consisted of 64 students of class VIII B and C at SMPN 02 Ponorogo. Data collection methods used include questionnaire data, observation sheet data and student worksheets. Based on the results of the study, it was obtained data that the results of the questionnaire related to student tolerance resulted in an increase of 48.44% in the comparison of Cycle I and Cycle II. This increase was also strengthened by data obtained from the results of the observation sheet related to the tolerance level of students which also showed an increase of 15.63%. Furthermore, the results of research related to the increase in learning outcomes obtained from student worksheets showed an increase of 31.25%. The conclusion of this study shows that the implementation of the STAD type cooperative learning method can increase students' tolerance attitude, as evidenced by questionnaires and observation sheets, while an increase in student learning outcomes can be proven by student worksheets.
Relationship of Mother’s Characteristics and Nutritional Status in Children in Indonesia
Authors: Marsianah Jeviya , Adhani Rosihan , Nugroho Adi , Husaini Husaini , Ilmi Bahrul 
Published: July 2022

Nutrition plays an important role in the human life cycle from in the womb to old age. The 2009 health law states that the main priority of efforts to improve nutrition in Indonesia is vulnerable groups, one of which is infants and toddlers. The results of the study used the Evidence Gap theory with the aim of analyzing the relationship between maternal characteristics and malnutrition status in children under five in Indonesia based on published studies from 2015-2020. The research method is meta-analysis with a cross sectional design. a total of six research articles (full text) published online in 2015-2020, using the meta-analysis calculator program Review Manager 5.4. The main results of the study were the age of mothers 20-35 years during pregnancy (85.4%), low education level of junior high school, not working parity of mothers with children > 1 (65.7%), and most of the number of children with no more than two children. (68.1%), most of the mother's birth spacing does not exist, and mother's knowledge is good. The conclusion from the six articles was that three articles were analyzed in the meta-analysis, namely maternal education p = 0.002 OR = 3.2, mother's occupation p = 0.002 OR = 2.70, and mother's knowledge p = 0.0001 OR = 4.98. That data mean that there was a relationship between significantly with the nutritional status of under-fives in Indonesia. Variables of mother's age, mother's parity, number of mother's children, and mother's birth spacing cannot be analyzed in the meta-analysis.Keywords: Characteristics of mothers, nutritional status, children under five
Antimicrobial Resistance of Escherichia coli and Salmonella isolated from Raw Retail Broiler Chicken Carcasses in Zambia
Authors: Muonga Elizabeth Muligisa , Mainda Geoffrey , Mukuma Mercy , Kwenda Geoffrey , Hang'ombe Bernard , Bumbangi Flavien , Phiri Nelson , Mwansa Mwaba , Munyeme Musso , Muma John Bwalya 
Published: July 2022

Abstract
Background Antimicrobial resistance (AMR) of foodborne pathogens is of public health concern, especially in developing countries such as Zambia. This study was undertaken to determine the antimicrobial resistance profiles of Escherichia coli (E. coli) and Salmonella isolated from raw retail broiler chicken carcasses purchased from open and supermarkets in Zambia.Results A total of 189 E. coli and five Salmonella isolates were isolated. Identification and confirmation of the isolates were done using Analytical Profile Index (API 20E) (Biomerieux®) and 16S rRNA sequencing. Antimicrobial susceptibility tests (AST) were performed using the Kirby Bauer disk diffusion technique using a panel of 10 antibiotics. Multiplex PCR was used to determine the presence of three target genes encoding for resistance: tetA, Sul1 and blaCTX-M. WHONET 2018 software was used to analyse AST results. The E. coli isolates were mostly resistant to tetracycline (79.4%), ampicillin (51.9%), and trimethoprim/sulfamethoxazole (49.7%). Two of the five Salmonella isolates were resistant to at least one antibiotic. Forty- seven (45.2%) of the 104 isolates that were screened for the presence of the resistant genes possessed at least one of the targeted resistance genes.Conclusion This study has demonstrated the presence of AMR E. coli and Salmonella on raw retail broiler chicken carcasses from open and supermarkets, which is of public health concern.
Predictors of intra-hospital mortality in patients with diabetic foot ulcers in Nigeria: data from the MEDFUN Study.
Authors: Adeleye Olufunmilayo O , Ugwu Ejiofor T , Gezawa Ibrahim D , Okpe Innocent , Ezeani Ignatius , Enamino Marcelina 
Published: July 2022

Abstract
Background: Diabetic foot ulcers (DFU) are associated with high morbidity and mortality globally. Mortality in patients hospitalized for DFU in Nigeria is unacceptably high. This study was undertaken to determine factors that predict mortality in patients hospitalized for DFU in Nigeria.Methods: The current study was part of Multi-centre Evaluation of Diabetic Foot Ulcer in Nigeria (MEDFUN), an observational study conducted in six tertiary healthcare institutions across the 6 geopolitical zones of Nigeria. Consecutive type 1 or 2 diabetic patients hospitalized for DFU who consented to participate were recruited and subjected to relevant clinical, biochemical, and radiological assessments and multidisciplinary care until discharge or death. Data for type 1 diabetes mellitus (DM) patients were expunged from current mortality analysis due to their small number.Results: Three hundred and twenty-three type 2 DM subjects with mean age and mean duration of DM of 57.2 11.4 years and 8.7± 5.8 years respectively participated in this study. The median duration of ulcers was 39 days with a range of 28 to 54 days and the majority (79.9%) presented with advanced ulcers of at least Wagner grade 3. Mortality of 21.4% was recorded in the study, with the highest mortality observed among subjects with Wagner grade 5. Variables significantly associated with mortality with their respective p values were DM duration more than 120 months (p 0.005), ulcer duration > one month (p 0.020), ulcer severity of Wagner grade 3 and above (p 0.001), peripheral arterial disease (p 0.005), proteinuria (p <0.001), positive blood cultures (p<0.001), low HDL (p <0.001), shock at presentation (p<0.001), cardiac failure (p 0.027),and renal impairment (p <0.001). On Multivariate regression analysis, presence of bacteraemia (OR 5.053; 95% CI 2.572-9.428) and renal impairment (OR 2.838; 95% CI 1.349 – 5.971) were significantly predictive of mortality independent of other variables.Conclusions: This study showed high intra-hospital mortality among patients with DFU, with the majority of deaths occurring among those with advanced ulcers, bacteraemia, cardiac failure, and renal impairment. Prompt attention to these factors might help improve survival from DFU in Nigeria.
Stability analysis of hybrid systems with higher order transverse discontinuity mapping
Authors: Chawla Rohit , Rounak Aasifa , Pakrashi Vikram 
Published: July 2022

Abstract
This article generalizes the implementation of higher order corrections to state transition matrices during instantaneous reversals in hybrid dynamical systems impacting a discontinuity boundary transversally. A closed form expression for saltation terms in systems possessing a degree of smoothness zero is derived. The difference in flight times of two closely initiated trajectories in state space to the impacting surface has been estimated up to O (2). A comparison of the times of impact estimated with the first order approximation reveals that higher order corrections lead to a significant improvement of estimates. Next, two new algorithms to estimate the Lyapunov spectrum and Floquet multipliers for piecewise-smooth systems have been presented using the derived second order corrections. Stability analyses are subsequently carried out using the proposed framework for two representative cases i.e., of a hard impact oscillator and a pair impact oscillator. It is established that the obtained Floquet multipliers and Lyapunov spectrum accurately predict the stability of the dynamical states, as validated by their corresponding bifurcation diagrams.
Flap Structure within Receptor Binding Domain of SARS-CoV-2 Spike Periodically Obstructs hACE2 Binding Subdomain Bearing Similarities to HIV-1 Protease Flap
Authors: Peters Michael H. 
Published: July 2022

Abstract
The SARS-CoV-2 prefusion spike protein is characterized by a high degree of flexibility and temporal transformations associated with its multifunctional behavior. In this study, we have examined the dynamics of the Receptor Binding Domain (RBD) of the SARS-CoV-2 spike protein in detail. Its primary, binding subdomain with human Angiotensin Covering Enzyme II includes a highly conspicuous flap or loop that is part of a beta hairpin loop structural motif. Dynamic details of the RBD obtained through RMSF and Order Parameter calculations are consistent with structural details including the stability of “glue” points or dominant interaction energy residues of the RBD in the Up and Down states with its neighboring N-terminal domain (NTD) protomer. The RBD flap in the Up state protomer periodically obstructs the binding site on an approximate 70 nanosecond time interval and is reminiscent of an HIV-1 protease polypeptide flap that opens and closes to modulate that enzymes activity. No claim is made here regarding the possible modulating role of the flap; however, the flap may be a potential site for therapeutic targeting aimed at keeping it in the closed state, as previously demonstrated in the inhibition of the HIV-1 protease polypeptide. The RBD primary binding subdomain is further shown to have not only similar dynamics but, also, an approximate 30% sequence similarity to the HIV-1 protease polypeptide.
Long-term monitoring indicates no adverse effects to intertidal habitats from biosolids applications onto an adjacent coastal forestry plantation
Authors: Campos Carlos , Berthelsen Anna , Gower Fiona , Floerl Lisa , Morrisey Don , Gillespie Paul 
Published: July 2022

Abstract
Stabilised organic solids derived from sewage sludge (‘biosolids’) are applied to land in many countries as an alternative to disposal as landfill. This study evaluates the long-term effects of biosolids applied to forestry plantations on the adjacent intertidal habitats of Moturoa / Rabbit Island (Aotearoa New Zealand). On this island, biosolids are applied to enhance soil fertility and growth of trees (Pinus radiata). However, applications may affect the quality of groundwater and surface water (e.g., increasing concentrations of nutrients and trace metals) and, via seepage into adjacent coastal areas, potentially adversely affect intertidal habitats and biota. Shoreline topography, macroalgal cover, sediment grain size, concentrations of nutrients, trace metals and faecal indicator bacteria, and benthic infaunal community characteristics were studied on three occasions (2008, 2014 and 2019) at twelve intertidal transect sites (four ‘reference’ and eight ‘application’) adjacent to forestry blocks where biosolids have been applied intermittently over a period of 24 years. No long-term adverse changes to the environment and community characteristics attributed to biosolids application were detected between reference and application sites. The study provides evidence that biosolids application can co-occur without detectable adverse effects on the nearby intertidal environment.