bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymerizable Deep Eutectic Solvent‐Based Skin‐Like Elastomers with Dynamic Schemochrome and Self‐Healing Ability
Authors: Li Xinkai , Liu Jize , Guo Quanquan , Zhang Xinxing , Tian Ming 
Published: April 2022

AbstractAnimal skin is a huge source of inspiration when it comes to multifunctional sensing materials. Bioinspired sensors integrated with the intriguing performance of skin‐like steady wide‐range strain detection, real‐time dynamic visual cues, and self‐healing ability hold great promise for next‐generation electronic skin materials. Here, inspired by the skins of a chameleon, cellulose nanocrystals (CNCs) liquid crystal skeleton is embedded into polymerizable deep eutectic solvent (PDES) via in situ polymerization to develop a skin‐like elastomer. Benefiting from the elastic ionic conductive PDES matrix and dynamic interfacial hydrogen bonding, this strategy has broken through the limitations that CNCs‐based cholesteric structure is fragile and its helical pitch is non‐adjustable, endowing the resulting elastomer with strain‐induced wide‐range (0–500%) dynamic structural colors and excellent self‐healing ability (78.9–90.7%). Furthermore, the resulting materials exhibit high stretch‐ability (1163.7%), strain‐sensing and self‐adhesive abilities, which make them well‐suitable for developing widely applicable and highly reliable flexible sensors. The proposed approach of constructing biomimetic skin‐like materials with wide‐range dynamic schemochrome is expected to extend new possibilities in diverse applications including anti‐counterfeit labels, soft foldable displays, and wearable optical devices.
Primary renal histiocytic sarcoma in a dog
Authors: Pitt Kathryn , Tremolada Giovanni 
Published: April 2022

AbstractA 5‐year‐old, male, neutered, Australian Shepherd mix was presented for evaluation of a left renal mass diagnosed by the primary veterinarian. The dog had a 2‐month history of lethargy, vomiting and hyporexia. Abdominal ultrasound confirmed the presence of a large (9.9 cm [L] × 7.8 cm [H] × 10.7 cm [W]) renal mass involving the entire left kidney causing severe hydronephrosis. A ureteronephrectomy was performed. Histopathology was consistent with renal histiocytic sarcoma. Adjuvant chemotherapy with cyclohexylchloroethylnitrosurea (62 mg/m2every 3 weeks for five treatments) was initiated. The dog had progressive disease upon restaging at the time of the third dose. Single‐agent doxorubicin (25 mg/m2every 2 weeks for five treatments) was started as a rescue protocol but discontinued after one dose due to side effects. The dog was euthanased 185 days after surgery.
High‐output cardiac failure in a dog secondary to hepatic vascular malformation
Authors: Williams Kristina , Hammond Hillary , Pierce Kursten V. 
Published: April 2022

AbstractA 2‐month‐old, 8.5 kg (18.7 lb), entire, female Chesapeake Bay Retriever presented for increased respiratory effort. Physical examination revealed a V/VI left basilar systolic heart murmur, mild dyspnoea and hepatomegaly. An echocardiogram revealed left‐sided volume overload, evidence of moderate pulmonary hypertension, markedly distended hepatic veins and caudal vena cava, and increased aortic and pulmonary flow velocities in the absence of overt structural heart disease, which was suspicious for high‐output cardiac failure. Thoracic radiographs revealed pulmonary oedema. An abdominal ultrasound revealed a hepatic vascular malformation. Medical management with furosemide was elected. A computed tomography was not pursued. The dog has done well over 9‐month follow‐up, with only one escalation in dose. Treatment of high‐output cardiac failure in a dog secondary to a hepatic vascular malformation has not been previously reported. Intervention to attenuate flow through the hepatic vascular malformation or portocaval shunt could be considered; however, short‐term treatment goals are controlling congestion.
PbTe/PbSe Thermoelectric Nanocomposites: The Impact of Length Modulations on Lowering Thermal Conductivity
Authors: Selli Daniele , Donadio Davide , Leoni Stefano 
Published: April 2022

AbstractPbTe and PbSe are among the most promising thermoelectric materials used in the mid‐temperature (400–900 K) power generation range. In these materials the efficiency increase in thermoelectric performance is critically related to the lowering of lattice thermal conductivity (κL), without compromising the electronic power factor. By means of state‐of‐the‐art equilibrium molecular dynamics (EMD), we investigate heat transport in several nanostructured PbTe/PbSe models as a function of material morphology. Layered composites show a reduction of the average κL of about 35 % with respect to the bulk. The insertion of PbSe nanoparticles into a PbTe matrix, or viceversa PbTe into PbSe reduces κL by up to 45 % while in more anisotropic nanocomposites the reduction exceeds PbSe/PbTe alloys. Layered composites show the lowest lattice thermal conductivity in the direction of layer stacking, for which an optimal thickness is identified. Along this line we provide a full account of the impact of alloying and (sub)nanostructuring on heat transport for this important class of materials. Particularly anisotropic nano‐dot morphologies and layered (sub)nanocomposites emerge as a paradigm for outstanding thermoelectric materials.
A large-area organic transistor with 3D-printed sensing gate for noninvasive single-molecule detection of pancreatic mucinous cyst markers
Authors: Sarcina Lucia , Viola Fabrizio , Modena Francesco , Picca Rosaria Anna , Bollella Paolo , Di Franco Cinzia , Cioffi Nicola , Caironi Mario , Österbacka Ronald , Esposito Irene , Scamarcio Gaetano , Torsi Luisa , Torricelli Fabrizio , Macchia Eleonora 
Published: April 2022

AbstractEarly diagnosis in a premalignant (or pre-invasive) state represents the only chance for cure in neoplastic diseases such as pancreatic-biliary cancer, which are otherwise detected at later stages and can only be treated using palliative approaches, with no hope for a cure. Screening methods for the purpose of secondary prevention are not yet available for these cancers. Current diagnostic methods mostly rely on imaging techniques and conventional cytopathology, but they do not display adequate sensitivity to allow valid early diagnosis. Next-generation sequencing can be used to detect DNA markers down to the physical limit; however, this assay requires labeling and is time-consuming. The additional determination of a protein marker that is a predictor of aggressive behavior is a promising innovative approach, which holds the potential to improve diagnostic accuracy. Moreover, the possibility to detect biomarkers in blood serum offers the advantage of a noninvasive diagnosis. In this study, both the DNA and protein markers of pancreatic mucinous cysts were analyzed in human blood serum down to the single-molecule limit using the SiMoT (single-molecule assay with a large transistor) platform. The SiMoT device proposed herein, which exploits an inkjet-printed organic semiconductor on plastic foil, comprises an innovative 3D-printed sensing gate module, consisting of a truncated cone that protrudes from a plastic substrate and is compatible with standard ELISA wells. This 3D gate concept adds tremendous control over the biosensing system stability, along with minimal consumption of the capturing molecules and body fluid samples. The 3D sensing gate modules were extensively characterized from both a material and electrical perspective, successfully proving their suitability as detection interfaces for biosensing applications. KRAS and MUC1 target molecules were successfully analyzed in diluted human blood serum with the 3D sensing gate functionalized with b-KRAS and anti-MUC1, achieving a limit of detection of 10 zM and 40 zM, respectively. These limits of detection correspond to (1 ± 1) KRAS and (2 ± 1) MUC1 molecules in the 100 μL serum sample volume. This study provides a promising application of the 3D SiMoT platform, potentially facilitating the timely, noninvasive, and reliable identification of pancreatic cancer precursor cysts.Graphical abstract
Analysis of six aromatic amines in the mainstream smoke of tobacco products
Authors: Ji Huihua , Jin Zhenyu 
Published: April 2022

AbstractAromatic amines are a class of carcinogenic compounds in tobacco smoke that are listed on the FDA list of harmful and potentially harmful constituents (HPHCs). A method using solid-phase microextraction-coupled to gas chromatography-triple quadrupole mass spectrometry (SPME headspace GC–MS/MS) was developed and validated for the quantitative determination of six aromatic amines, including 1-aminonaphthalene (1-AN), 2-aminonaphthalene (2-AN), 3-aminobiphenyl (3-ABP), 4-aminobiphenyl (4-ABP), o-toluidine (o-TOL), and o-anisidine (o-ANI), in the mainstream smoke of cigarettes, cigars, and heated tobacco products. The method developed here combines high sensitivity with simple sample preparation and has demonstrated satisfactory linearity for all six aromatic amines with correlation coefficients greater than 0.9994. The limits of detection range and the limits of quantitation range were 12–96 pg/mL and 41–320 pg/mL, respectively. Their recoveries and coefficients of variation (CV%) were 90–112% and 2.1–6.6%, respectively. The new SPME headspace GC/MS/MS method has been successfully applied to measure the contents of the six aromatic amines in the mainstream smoke of cigarettes, cigars, and heated tobacco products.
Joint EANM, SNMMI and IAEA enabling guide: how to set up a theranostics centre
Authors: Herrmann Ken , Giovanella Luca , Santos Andrea , Gear Jonathan , Kiratli Pinar Ozgen , Kurth Jens , Denis-Bacelar Ana M. , Hustinx Roland , Patt Marianne , Wahl Richard L. , Paez Diana , Giammarile Francesco , Jadvar Hossein , Pandit-Taskar Neeta , Ghesani Munir , Kunikowska Jolanta 
Published: April 2022

AbstractThe theranostics concept using the same target for both imaging and therapy dates back to the middle of the last century, when radioactive iodine was first used to treat thyroid diseases. Since then, radioiodine has become broadly established clinically for diagnostic imaging and therapy of benign and malignant thyroid disease, worldwide. However, only since the approval of SSTR2-targeting theranostics following the NETTER-1 trial in neuroendocrine tumours and the positive outcome of the VISION trial has theranostics gained substantial attention beyond nuclear medicine. The roll-out of radioligand therapy for treating a high-incidence tumour such as prostate cancer requires the expansion of existing and the establishment of new theranostics centres. Despite wide global variation in the regulatory, financial and medical landscapes, this guide attempts to provide valuable information to enable interested stakeholders to safely initiate and operate theranostics centres. This enabling guide does not intend to answer all possible questions, but rather to serve as an overarching framework for multiple, more detailed future initiatives. It recognizes that there are regional differences in the specifics of regulation of radiation safety, but common elements of best practice valid globally.
Minimally Invasive Parathyroidectomy: Can Intraoperative Parathyroid Hormone Monitoring be Omitted?
Authors: Eligal Shalom , Mekel Michal , Weinberger Jeffrey M. , Neymark Mariya , Hirshoren Nir , Mizrahi Ido , Eliashar Ron , Mazeh Haggi 
Published: April 2022

AbstractBackgroundIntraoperative PTH (ioPTH) monitoring has become widely accepted in the era of minimally invasive parathyroidectomy (MIP). The purpose of this study was to evaluate the need for ioPTH during parathyroidectomy in patients with positive preoperative imaging.MethodsThe charts of patients who underwent parathyroidectomy at three tertiary centers between the years 2012 and 2021 were retrospectively reviewed. Patients were defined as MIP candidates with either concordant preoperative imaging or a single positive imaging. Patients with negative or discordant imaging, concomitant thyroidectomy, or previous neck surgery were excluded.ResultsOf a total of 1013 patients who underwent parathyroidectomy, 535 (52.8%) were defined as MIP candidates and were included in the statistical analysis. Surgical success was achieved in all patients. A single adenoma that corresponded to the preoperative imaging was identified and resected in 517 (93.8%) patients. In only 18 (3.3%) patients, the ioPTH correctly changed the operative management where additional pathologic glands were identified and excised. Patients with additional lesions were significantly more likely to have decreased index adenoma size as indicated either by preoperative imaging or by intraoperative findings (15.5 ± 6.6 vs. 8.3 ± 2.5 mm, p < 0.001). None of the patients with an adenoma size greater than 13 mm had an additional pathologic gland.ConclusionsOur findings suggest that the routine use of ioPTH in MIP candidates may be omitted in patients with an index adenoma greater than 13 mm, even with only a single positive preoperative imaging study, without compromising surgical success.
„Satellitenlabore“ – ein Projekt zur Förderung informatischer Bildung an weiterführenden Schulen
Authors: Tillmann Jonas , Wegner Claas 
Published: April 2022

ZusammenfassungDas vorliegende Forschungsvorhaben beschäftigt sich mit dem Projekt „Satellitenlabore“ zur Unterstützung und Förderung informatischer Bildung an weiterführenden Schulen als ganzheitlichen Ansatz, welches die unterschiedlichen Akteure (Schulen, außerschulische Einrichtungen und Unternehmen) stärker verknüpfen soll. Gemäß des Design-Based-Research-Modells nach Shavelson et al. werden auf Grundlage des erhobenen Forschungsstandes in einem weiteren Schritt unterschiedliche Interventionsmaßnahmen entwickelt und didaktische Konzepte abgeleitet, die in mehrfachen Erprobungen stetig evaluiert und weiterentwickelt werden sollen.
A new picking algorithm based on the variance piecewise constant models
Authors: D’Angelo Nicoletta , Di Benedetto Andrea , Adelfio Giada , D’Alessandro Antonino , Chiodi Marcello 
Published: April 2022

AbstractIn this paper, we propose a novel picking algorithm for the automatic P- and S-waves onset time determination. Our algorithm is based on the variance piecewise constant models of the earthquake waveforms. The effectiveness and robustness of our picking algorithm are tested both on synthetic seismograms and real data. We simulate seismic events with different magnitudes (between 2 and 5) recorded at different epicentral distances (between 10 and 250 km). For the application to real data, we analyse waveforms from the seismic sequence of L’Aquila (Italy), in 2009. The obtained results are compared with those obtained by the application of the classic STA/LTA picking algorithm. Although the two algorithms lead to similar results in the simulated scenarios, the proposed algorithm results in greater flexibility and automation capacity, as shown in the real data analysis. Indeed, our proposed algorithm does not require testing and optimization phases, resulting potentially very useful in earthquakes routine analysis for novel seismic networks or in regions whose earthquakes characteristics are unknown.
GGS-groups over primary trees: branch structures
Authors: Di Domenico E. , Fernández-Alcober G. A. , Gavioli N. 
Published: April 2022

AbstractWe study branch structures in Grigorchuk–Gupta–Sidki groups (GGS-groups) over primary trees, that is, regular rooted trees of degree $$p^n$$

p
n

for a prime p. Apart from a small set of exceptions for $$p=2$$

p
=
2

, we prove that all these groups are weakly regular branch over $$G''$$

G

′
′

. Furthermore, in most cases they are actually regular branch over $$\gamma _3(G)$$

γ
3

(
G
)

. This is a significant extension of previously known results regarding periodic GGS-groups over primary trees and general GGS-groups in the case $$n=1$$

n
=
1

. We also show that, as in the case $$n=1$$

n
=
1

, a GGS-group generated by a constant vector is not branch.
Retinal thinning in progressive supranuclear palsy: differences with healthy controls and correlation with clinical variables
Authors: Picillo Marina , Salerno Giulio , Tepedino Maria Francesca , Abate Filomena , Cuoco Sofia , Gioia Marco , Coppola Alessia , Erro Roberto , Pellecchia Maria Teresa , Rosa Nicola , Barone Paolo , De Bernardo Maddalena 
Published: April 2022

Abstract

Background
Available evidence reports conflicting data on retinal thickness in progressive supranuclear palsy (PSP). In studies including healthy controls, PSP showed either the thinning of the retinal nerve fiber layer, macular ganglion cell, inner nuclear, or outer retina layer.

Objectives
The goals of the present study were to describe retinal layer thickness in a large cohort of PSP compared to healthy controls and in PSP phenotypes using spectral-domain optical coherence tomography (SD-OCT). The additional objective was to verify the relationship between retinal layers thickness and clinical variables in PSP.

Methods
Using a cross-sectional design, we examined retinal structure in 27 PSP patients and 27 controls using standard SD-OCT. Motor and cognitive impairment in PSP was rated with the PSP rating scale and the Montreal Cognitive Assessment battery (MoCA), respectively. Eyes with poor image quality or confounding diseases were excluded. SD-OCT measures of PSP and controls were compared with parametric testing, and correlations between retinal layer thicknesses and disease severity were evaluated.

Results
PSP showed significant thinning of the inner retinal layer (IRL), ganglion cell layer (GCL), inner plexiform layer (IPL), and the outer plexiform layer (OPL) compared to healthy controls. PSP phenotypes showed similar retinal layer thicknesses. Retinal layer thickness correlated with MoCA visuospatial subscore (p < 0.001).

Conclusions
We demonstrated PSP patients disclosed thinner IRL, GCL, IPL, and OPL compared to healthy controls. Furthermore, we found a significant correlation between visuospatial abilities and retinal layers suggesting the existence of a mutual relationship between posterior cognitive function and retinal structure.
Microsurgical clipping vs Woven EndoBridge (WEB) device for the management of unruptured wide-neck bifurcation aneurysms
Authors: Chacón-Quesada Tatiana , Mielke Dorothee , Rohde Veit , Hernández-Durán Silvia 
Published: April 2022

Abstract
The Woven EndoBridge device (WEB) was introduced in 2010 to treat wide-neck bifurcation aneurysms (WNBAs). Three landmark studies have been conducted to assess its safety and efficacy: WEBCAST, WEBCAST 2, and French Observatory Study. However, these studies have not compared its safety and efficacy to other treatment modalities. In this study, we compare WEB versus microsurgical clipping in the management of unruptured WNBA. We conducted a retrospective study of unruptured WNBA meeting the morphological criteria to be amenable for WEB treatment operated on at our institution. Surgical morbidity, mortality, and occlusion rates were assessed. We compared our results to those reported in the cumulative population of the three WEB landmark studies at 1 year. A total of 84 patients with 89 WNBA were included. The most common aneurysm location was the middle cerebral artery bifurcation (n = 67/89, 75%). No operative mortality was observed. Morbidity comprised small-vessel vasospasm (n = 1/89, 1%) resulting in hemiparesis vs. 3% morbidity for WEB (p = .324). All but one (n = 1/89, 1%) WNBA were completely occluded vs WEB occlusion rate of 53% at 1 year, statistically significantly worse (p < .001). In our analysis, we were not able to show superiority of WEB in terms of procedural morbidity in comparison to microsurgical clipping, defined as worsening in mRS. Microsurgical clipping achieves statistically significantly higher rates of complete aneurysm occlusion, thus posing the question of whether the WEB should be presented as a viable, comparable alternative to patients amenable to surgical treatment.
As time goes by–developments in surgery for esophageal cancer in the new millennium
Authors: Lindenmann Joerg , Maier Alfred , Fediuk Melanie , Mykoliuk Iurii , Roj Andrej , Anegg Udo , Smolle Josef , Smolle-Juettner Freyja Maria 
Published: April 2022

Summary
Background
In the last two decades, both treatment options and epidemiological features of cancer have changed. We studied the influence of related parameters on the outcome of patients undergoing resection for esophageal carcinoma.

Methods
We analyzed 499 consecutive patients who underwent esophagectomy for carcinoma since January 2000, comparing 2000–2010 with 2011–2021 and examining changes over time.

Results
The percentage of men (87.9 vs. 86.9%; p = 0.74) in the two groups was unchanged, whereas mean age increased significantly from 60.8 to 65.2 years (p = 0.000). There was a trend towards an increase of adenocarcinoma (gamma = 0.120, ASE = 0.055). Despite significantly increasing use of induction chemoradiotherapy (p = 0.000) from 7.14% in 2000 to 68.9% in 2021 the distribution of pT, pN stage, grading and the rate of positive lateral resection margins remained unchanged. When comparing the two periods, the overall 30-day mortality was 4.4 vs. 4.2% (p = 0.56), recurrence-free survival was 36.9 vs. 38% at 60 months and 33.9 vs. 36.4% at 120 months (p = 0.93). Tumor-associated survival was 41.1 vs. 45% at 60 months and 35.5 vs. 38.7% at 120 months (p = 0.78). None of the survival rates differed significantly. A multivariable analysis of year of surgery, age, sex, histological subtype, grading, pT, pN, lateral resection margin, and induction therapy showed that only higher pT (p = 0.01), positive pN (p = 0.000), positive lateral margin (p = 0.003), squamous cell carcinoma (p = 0.04) and higher grading (p = 0.026) had a statistically significant, independent, negative influence on prognosis.

Conclusion
Optimized noninvasive and invasive therapeutic modalities have produced only marginal improvement in the prognosis of esophageal cancer within the last two decades.
The influence of sociodemographic factors and close relatives at hospital discharge and post hospital care of older people with complex care needs: nurses’ perceptions on health inequity in three Nordic cities
Authors: Liljas A. E. M. , Jensen N. K. , Pulkki J. , Andersen I. , Keskimäki I. , Burström B. , Agerholm J. 
Published: April 2022

AbstractHospital discharge of older people in need of both medical and social care following their hospital stay requires extensive coordination. This study aims to examine and compare the views of nurses in three Nordic cities on the influence of sociodemographic factors and having close relatives, for the hospital discharge and post hospital care of older people with complex health and social care needs. Thirty-five semi-structured interviews (Copenhagen n = 11, Tampere n = 8, Stockholm n = 16) with nurses were conducted. The nurses were identified through the researchers’ networks, invitation and snowball sampling, and recruited from hospitals, primary care practices, home care units, home nursing units, and geriatric departments. The interviews were transcribed and analysed using thematic analysis. Interpretations were discussed and agreed within the team. Four main themes and 13 sub-themes were identified. Across the cities, informants reported that the patient’s health status, rather than their gender or ethnicity, steered the discharge date and further care. Care costs, commonly reported in Tampere but also in Copenhagen and Stockholm including costs for medications and home help, were considered barriers for disadvantaged older people. Home situation, local arrangements and differences in collaboration between healthcare professionals at different sites also influenced the hospital discharge. Generally, the patient’s health status steered the hospital discharge and post-hospital care. Close relatives were regarded important and a potential advantage. Some informants tried to compensate for the absence of close relatives, highlighting the importance of care systems that can compensate for this to minimise avoidable inequity.