bluuebunny/crossref_metadata_2025_split huggingface dataset:
The longitudinal trajectory of emotion regulation and associated neural activity in patients with bipolar disorder: A prospective fMRI study
Authors: Kjærstad Hanne Lie , de Siqueira Rotenberg Luisa , Knudsen Gitte Moos , Vinberg Maj , Kessing Lars Vedel , Macoveanu Julian , Lafer Beny , Miskowiak Kamilla Woznica 
Published: August 2022

AbstractObjectivesImpaired emotion regulation is a key feature of bipolar disorder (BD) that presents during acute mood episodes and in remission. The neural correlates of voluntary emotion regulation seem to involve deficient prefrontal top‐down regulation already at BD illness onset. However, the trajectory of aberrant neuronal activity during emotion regulation in BD is unclear.MethodsWe investigated neural activity during emotion regulation in response to aversive pictures from the International Affective Picture System in patients with recently diagnosed BD (n = 43) in full or partial remission and in healthy controls (HC) (n = 38) longitudinally at baseline and 16 months later.ResultsPatients with BD exhibited stable hypo‐activity in the left dorsomedial prefrontal cortex (DMPFC) and right dorsolateral prefrontal cortex (DLPFC) and impaired emotion regulation compared to HC over the 16 months follow‐up time. More DLPFC hypo‐activity during emotion regulation correlated with less successful down‐regulation (r = 0.16, p = 0.045), more subsyndromal depression (r = −0.18, p = 0.02) and more functional impairment (r = −0.24, p = 0.002), while more DMPFC hypo‐activity correlated with less efficient emotion regulation (r = 0.16, p = 0.048). Finally, more DMPFC hypo‐activity during emotion regulation at baseline was associated with an increased likelihood of subsequent relapse during the 16 months follow‐up time (β = −2.26, 95% CI [0.01; 0.99], p = 0.048).ConclusionThe stable DLPFC and DMPFC hypo‐activity during emotion regulation represents a neuronal trait‐marker of persistent emotion regulation difficulties in BD. Hypo‐activity in the DMPFC may contribute to greater risk of relapse.
Long‐term changes in milk component immunoglobulins reflect milk oral immunotherapy outcomes in Finnish children
Authors: Kauppila Tiina Kaisa , Hinkkanen Victoria , Savinko Terhi , Karisola Piia , Kukkonen Anna Kaarina , Paassilta Marita , Pelkonen Anna S. , Mäkelä Mika J. 
Published: August 2022

AbstractBackgroundMilk oral immunotherapy (OIT) may increase the amount of milk protein that can be ingested without triggering an allergic reaction. It is important to understand why some patients benefit from the treatment while others do not.ObjectiveThe aim was to define the differences in the milk allergen component‐specific (casein, α‐lactalbumin, ß‐lactoglobulin) immunoglobulin (sIg [sIgE, sIgG4, and sIgA]) levels relative to the long‐term outcomes of milk OIT.MethodsIn this long‐term, open‐label follow‐up study, 286 children started milk OIT between 2005 and 2015. Follow‐up data were collected at two points: the post‐buildup phase and long term (range 1–11 years, median 6 years). Comparisons of sIg levels were made among three outcome groups of self‐reported long‐term milk consumption (high‐milk dose, low‐milk dose, and avoidance).ResultsA total of 168 (59%) of the 286 patients on OIT participated. Most patients (57%) were in the high‐dose group; here, 80% of these patients had a baseline casein sIgE value less than 28 kUA/L, they had the lowest casein sIgE levels at all time (p < .001), their casein sIgG4/IgE levels increased, and long‐term casein sIgA was highest compared with the low‐dose and avoidance groups (p = .02). Low‐milk dose group had the highest casein sIgG4/IgE levels in long term (p = .002).ConclusionThe baseline Ig profiles and responses to milk OIT differed depending on long‐term milk consumption. Lower casein sIgE levels were associated with better outcome. Milk casein sIgA differed in the long term among high‐milk consumers.
SHARPIN promotes cell proliferation of cholangiocarcinoma and inhibits ferroptosis via p53/SLC7A11/GPX4 signaling
Authors: Zeng Chong , Lin Jie , Zhang Ketao , Ou Huohui , Shen Ke , Liu Qingbo , Wei Zibo , Dong Xinhuai , Zeng Xiaokang , Zeng Liming , Wang Weidong , Yao Jie 
Published: August 2022

AbstractSHARPIN is a tumor‐associated gene involved in the growth and proliferation of many tumor types. A function of SHARPIN in cholangiocarcinoma (CCA) is so far unclear. Here, we studied the role and function of SHARPIN in CCA and revealed its relevant molecular mechanism. The expression of SHARPIN was analyzed in cholangiocarcinoma tissues from patients using immunohistochemistry, quantitative PCR, and western blot analysis. Expression of SHARPIN was suppressed/overexpressed by siRNA silencing or lentiviral overexpression vector, and the effect on cell proliferation was determined by the CCK‐8 assay and flow cytometry. Accumulation of reactive oxygen species was measured with MitoTracker, and JC‐1 staining showed mitochondrial fission/fusion and mitochondrial membrane potential changes as a result of the silencing or overexpression. The ferroptosis marker solute carrier family 7 member 11 (SLC7A11), glutathione peroxidase 4 (GPX4), and the antioxidant enzymes superoxide dismutase 1 (SOD‐1) and SOD‐2 were analyzed by western blot. The results showed that SHARPIN expression was increased in CCA tissue, and this was involved in cell proliferation. SHARPIN silencing resulted in accumulated reactive oxygen species, reduced mitochondrial fission, and a reduced mitochondrial membrane potential. Silencing of SHARPIN inhibited the ubiquitination and degradation of p53, and downregulated levels of SLC7A11, GPX4, SOD‐1, and SOD‐2, all of which contributed to excessive oxidative stress that leads to ferroptosis. Overexpression of SHARPIN would reverse the above process. The collected data suggest that in CCA, SHARPIN‐mediated cell ferroptosis via the p53/SLC7A11/GPX4 signaling pathway is inhibited. Targeting SHARPIN might be a promising approach for the treatment of CCA.
Measuring respiratory syncytial virus infection severity in hospitalized children using the Pediatric Respiratory Syncytial Virus Electronic Severity and Outcome Rating System (PRESORS)
Authors: Vandendijck Yannick , Scott Jane , Heerwegh Dirk , Van Der Elst Wim , Witek James , Sinha Rekha , Fennema Hein 
Published: August 2022

AbstractBackgroundThe Pediatric Respiratory Syncytial Virus Electronic Severity and Outcome Rating System (PRESORS) was developed to assess the severity of respiratory syncytial virus (RSV) infection in children. Because young children cannot report how they feel or function, ratings are based on observations by the child's caregiver (Observer‐Reported Outcome questionnaire [ObsRO]) and clinician (Clinician‐Reported Outcome questionnaire [ClinRO]). This prospective study aimed to evaluate the psychometric properties of the PRESORS.MethodsThe PRESORS version 6 ObsRO and ClinRO were evaluated in children with RSV infection requiring hospitalization in centers in the United States, Argentina, and Chile. Assessments were performed from days 1 to 7 by the child's caregiver and clinician. To assess inter‐rater reliability, two clinicians independently performed the ClinRO near in time.ResultsA total of 124 children aged ≤36 months were enrolled (mean age, 8 months). Factor analysis demonstrated that RSV severity consists of two dimensions, respiratory signs and illness behavior, and that these dimensions were consistent over time. The inter‐rater reliability for the ClinRO was 0.66 (95% confidence interval [CI], 0.55–0.75) but improved to 0.79 (95% CI, 0.71–0.86) after removing one outlying site, suggesting that quantifying RSV severity is not trivial, even using qualified raters, but that an adequate inter‐rater reliability is achievable with the PRESORS through adequate training. ClinRO and ObsRO displayed acceptable internal consistency and acceptable convergent validity with the Respiratory Syncytial Virus Network Scale, global impression scores, and key hospital characteristics.ConclusionsThe PRESORS is relevant and appropriate for assessing the severity of RSV infection in infants requiring hospitalization.
Pediatric burden and seasonality of human metapneumovirus over 5 years in Managua, Nicaragua
Authors: Hacker Kathryn , Kuan Guillermina , Vydiswaran Nivea , Chowell‐Puente Gerardo , Patel Mayuri , Sanchez Nery , Lopez Roger , Ojeda Sergio , Lopez Brenda , Mousa Jarrod , Maier Hannah E. , Balmaseda Angel , Gordon Aubree 
Published: August 2022

AbstractBackgroundHuman metapneumovirus (hMPV) is an important cause of pediatric respiratory infection. We leveraged the Nicaraguan Pediatric Influenza Cohort Study (NPICS) to assess the burden and seasonality of symptomatic hMPV infection in children.MethodsNPICS is an ongoing prospective study of children in Managua, Nicaragua. We assessed children for hMPV infection via real‐time reverse‐transcription polymerase chain reaction (RT‐PCR). We used classical additive decomposition analysis to assess the temporal trends, and generalized growth models (GGMs) were used to estimate effective reproduction numbers.ResultsFrom 2011 to 2016, there were 564 hMPV symptomatic infections, yielding an incidence rate of 5.74 cases per 100 person‐years (95% CI 5.3, 6.2). Children experienced 3509 acute lower respiratory infections (ALRIs), of which 160 (4.6%) were associated with hMPV infection. Children under the age of one had 55% of all symptomatic hMPV infections (62/112) develop into hMPV‐associated ALRIs and were five times as likely as children over one to have an hMPV‐associated ALRI (rate ratio 5.5 95% CI 4.1, 7.4 p < 0.001). Additionally, symptomatic reinfection with hMPV was common. In total, 87 (15%) of all observed symptomatic infections were detected reinfections. The seasonality of symptomatic hMPV outbreaks varied considerably. From 2011 to 2016, four epidemic periods were observed, following a biennial seasonal pattern. The mean ascending phase of the epidemic periods were 7.7 weeks, with an overall mean estimated reproductive number of 1.2 (95% CI 1.1, 1.4).ConclusionsSymptomatic hMPV infection was associated with substantial burden among children in the first year of life. Timing and frequency of symptomatic hMPV incidence followed biennial patterns.
The Capture of EU Football Regulation by the Football Governing Bodies
Authors: Meier Henk Erik , García Borja , Yilmaz Serhat , Chakawata Webster 
Published: August 2022

AbstractThe article traces how European football regulation has been ‘captured’ by the football governing bodies. The European Commission re‐aligned with the European football governing body Union des Associations Européennes de Football (UEFA), which enabled the latter to solidify its role as industry regulator. Four factors seem to account for the successful capture of European football regulation by UEFA. (1) UEFA enjoys a substantial mobilization advantage. (2) As legitimacy maximizer, the Commission avoids unnecessary confrontations. (3) Substantial interest heterogeneity amongst football stakeholders such as clubs, players and leagues prevented the emergence of strong countervailing constituencies to oppose UEFA regulatory proposals. (4) The legacy of amateur ideology in European football nurtures a strong socio‐cultural regulatory frame, which depicts the football governing bodies as trustees of the public interest in football as community institution. The findings come with implications for EU football regulation and the limits of the EU regulatory state.
Spontaneous intranasal tumours in degus (Octodon degus): 20 cases (2007‐2020)
Authors: Nakata M. , Miwa  , Wu C. C. , Chambers J. K. , Uchida K. , Shiga  , Nakayama H. , Sasaki  
Published: August 2022

ObjectiveThe objective of this retrospective study was to describe the clinical and histopathological findings associated with intranasal tumours in degus.Materials and MethodsMedical records of degus diagnosed with intranasal neoplasms on histopathological examination between the years 2007 and 2020 at one hospital were included in the study.Results Medical records of degusTwenty degus (10 males and 10 females) were eligible for inclusion. Initial clinical signs included sneezing, abnormal nasal sounds, and nasal discharge, followed by anorexia and frequent nose rubbing. On radiography, 15 out of 20 animals showed space‐occupying lesions in the nasal cavity. CT was performed in 16 animals and revealed various degrees of changes, including abnormal radiopacity within the nasal cavity and damaged nasal septum. Rhinostomy and excisional biopsy was performed in all 20 animals. Six out of 20 patients died during the perioperative period. Six and seven degus survived for 3 months and 1 year, respectively. One animal was lost to follow‐up. In 16 cases the histological diagnosis was consistent with fibromas, while in 4 cases with osteomas.Clinical SignificanceIntranasal neoplasms in degus are mostly benign mesenchymal tumours with various degrees of bone formation, which is unique to this animal species. This occurrence should be considered as an important differential diagnosis for upper respiratory tract disease in degus.
Novel chlorine-extending polymer coating with prolonged antiviral activity against SARS-CoV-2
Authors: Zhang Y. , Choi Y. W. , Demir B. , Ekbataniamiri F. , Fulton M. L. , Ma M. , Schang L. M. , Purevdorj-Gage L. , Qiao M. 
Published: August 2022

Abstract
We previously reported a novel polymeric surface coating, namely, HaloFilm™ that can immobilize and extend the antimicrobial activity of chlorine on surfaces. In this study, we demonstrated the continuous antiviral efficacy of HaloFilm when applied on stainless steel and cotton gauze as two representative models for non-porous and porous surfaces against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Forty-eight hours post HaloFilm application and chlorination and 2 h post the viral challenge, the inoculum titre was reduced by 2.25 ± 0.33 and ≥4.36 ± 0.23 log10 TCID50 on non-porous and porous surfaces, respectively. The half-life of the virus was shorter (13.86 min) on a HaloFilm-coated surface than what has been reported on copper (46.44 min).
Reticulocyte hemoglobin content changes after treatment of anemia of prematurity
Authors: Nii Mitsumaro , Okamoto Toshio , Sugiyama Tatsutoshi , Aoyama Aiko , Nagaya Ken 
Published: August 2022

AbstractBackgroundIron deficiency during infancy is associated with poor neurological development, but iron overload causes severe complications. Appropriate iron supplementation is therefore vital. Reticulocyte hemoglobin content (RET‐He) provides a real‐time assessment of iron status and chracterezes hemoglobin synthesis in preterm infants. However, the existing literature lacks detailed reports assessing chronological changes in RET‐He. The aim of this study was to assess the chronological changes in RET‐He during oral iron dietary supplementation, and concomitant therapy with recombinant human erythropoietin (rHuEPO) in preterm very low birthweight infants.MethodsVery low birthweight infants, admitted to our neonatal intensive care unit were analyzed retrospectively. Hemoglobin (Hb), reticulocyte percentage (Ret), mean corpuscular volume, RET‐He, serum iron (Fe), and serum ferritin were recorded. Data at birth (T0), the initial day of rHuEPO therapy (T1), the initial day of oral iron supplementation (T2), 1–2 weeks (T3), 3–4 weeks (T4), 5–6 weeks (T5), and 7–8 weeks (T6) from the initial day of oral iron supplementation were extracted, and their changes over time were examined.ResultsReticulocyte hemoglobin content was highest at birth and declined rapidly thereafter, especially after starting rHuEPO therapy. There was no upward trend in RET‐He after the initiation of oral iron supplementation, with a slower increase during 5–6 weeks after the initiation of iron therapy.ConclusionsDuring the treatment of anemia of prematurity, low RET‐He levels may be prolonged. Anemia of prematurity should therefore be assessed and treated on a case‐by‐case basis, while considering the iron metabolic capacity of preterm infants.
International cooperation in foreign reserve policies in the presence of competitive hoarding
Authors: Lee Dongwon 
Published: August 2022

AbstractThis article analyzes the international reserve accumulation behavior of emerging and developing economies facing “keeping‐up‐with‐the‐Joneses” externalities. I first document empirical evidence for a significant Joneses effect, which has been particularly persistent in Asia and Latin America since the late 1990s. This peer‐pressure motive could encourage excess reserve hoarding, providing a rationale for cooperation. I then develop a theoretical model of the borrowing economy featuring the Joneses effect and the interdependence between reserves and domestic capital investment. Numerical results show that international cooperation can effectively internalize negative externalities associated with competitive reserve hoarding and induce welfare‐enhancing resource allocations.
Rapid brain MRI protocols result in comparable differential diagnoses versus a full brain protocol in most canine and feline cases
Authors: Johnson Kelsey A. , Sutherland‐Smith James , Oura Trisha J. , Sato Amy F. , Barton Bruce 
Published: August 2022

AbstractEvaluation of brain disease in veterinary patients uses a wide variety of MRI sequences. A shortened protocol that maintains consistency of interpretation would reduce radiologist reporting time, patient anesthetic time, and client cost. The aims of this retrospective, methods comparison, observer agreement study were to evaluate whether abbreviated MRI protocols alter differential diagnoses and recommendations compared to our institution's standard protocol; evaluate interobserver agreement on standard brain MRIs; and assess whether differential diagnoses change after postcontrast images. Normal and pathologic canine and feline brain MRIs were retrieved from hospital archives. Three protocols were created from each: a 5‐sequence noncontrast enhanced Fast Brain Protocol 1 (FBP1); a 6‐sequence contrast‐enhanced Fast Brain Protocol 2 (FBP2); and an 11‐sequence standard brain protocol (SBP). Three blinded veterinary radiologists interpreted FBP images for 98 cases (1 reader/case) and SBP images for 20 cases (3 readers/case). A fourth observer compared these interpretations to the original MRI reports (OMR). Overall agreement between FBPs and OMR was good (k = 0.75) and comparable to interobserver agreement for multiple reviews of SBP cases. Postcontrast images substantially altered conclusions in 17/97 cases (17.5%), as well as improved interobserver agreement compared to noncontrast studies. The conclusions reached with shortened brain protocols were comparable to those of a full brain study. The findings supported the use of a 6‐sequence brain MRI protocol (sagittal T2‐weighted [T2w] TSE; transverse T2w turbo spin echo fluid‐attenuated inversion recovery, T2*‐weighted gradient recalled echo, T1‐weighted spin echo, and diffusion weighted imaging/apparent diffusion coefficient; and postcontrast transverse T1‐weighted spin echo) for dogs and cats with suspected intracranial disease.
Alterations to the synovial invaginations of the navicular bone are associated with pathology of both the navicular apparatus and distal interphalangeal joint when evaluated using high field MRI
Authors: McParland Thomas J. , Horne Caitlyn R. , Robertson James B. , Schnabel Lauren V. , Nelson Nathan C. 
Published: August 2022

AbstractLimited information exists regarding associations between distal interphalangeal joint (DIPJ) abnormalities and synovial invagination changes in the distal sesamoid (navicular) bone. This retrospective, analytical study aimed to measure specific characteristics of the synovial invaginations of the navicular bone to determine whether any single characteristic was associated with abnormalities in the DIPJ or navicular apparatus (NA) using high field MRI and a sample of 200 horses’ feet. The DIPJ and NA were graded independently by three scorers. The grades were averaged, creating a global pathology score for the DIPJ, NA, and synovial invaginations. Higher global scores represented more severe pathology. The number of invaginations, depth of penetration, invagination shape, and cross‐sectional area (CSA) of the largest invagination were recorded. Interobserver agreement was measured using Cohen's Kappa. Associations of global scores of the DIPJ and NA with individual invagination characteristics were assessed using linear mixed modeling. A significant relationship was found between the number of invaginations and global DIPJ score, with higher invagination numbers associated with higher DIPJ scores. For invagination depth and CSA, a significant relationship was noted with global scores of both the DIPJ and NA. Reliable relationships between the shape of synovial invaginations and global scores of DIPJ and NA were not found, likely due to poor interobserver scoring (0.305). These findings suggest that primary DIPJ disease and NA pathology should be considered when noticing alterations to navicular synovial invaginations on MRI. This contrasts traditional views that synovial invagination abnormalities are indicative solely of NA pathology.
TCR-Independent Metabolic Reprogramming Precedes Lymphoma-Driven Changes in T-cell Fate
Authors: Hesterberg Rebecca S. , Liu Min , Elmarsafawi Aya G. , Koomen John M. , Welsh Eric A. , Hesterberg Stephen G. , Ranatunga Sujeewa , Yang Chunying , Li Weimin , Lawrence Harshani R. , Rodriguez Paulo C. , Berglund Anders E. , Cleveland John L. 
Published: August 2022

Abstract

Chronic T-cell receptor (TCR) signaling in the tumor microenvironment is known to promote T-cell dysfunction. However, we reasoned that poorly immunogenic tumors may also compromise T cells by impairing their metabolism. To address this, we assessed temporal changes in T-cell metabolism, fate, and function in models of B-cell lymphoma driven by Myc, a promoter of energetics and repressor of immunogenicity. Increases in lymphoma burden most significantly impaired CD4+ T-cell function and promoted regulatory T cell (Treg) and Th1-cell differentiation. Metabolomic analyses revealed early reprogramming of CD4+ T-cell metabolism, reduced glucose uptake, and impaired mitochondrial function, which preceded changes in T-cell fate. In contrast, B-cell lymphoma metabolism remained robust during tumor progression. Finally, mitochondrial functions were impaired in CD4+ and CD8+ T cells in lymphoma-transplanted OT-II and OT-I transgenic mice, respectively. These findings support a model, whereby early, TCR-independent, metabolic interactions with developing lymphomas limits T cell–mediated immune surveillance.