bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovative component positioning method for thermoformed electronics
Authors: Madadnia Behnam , Bossuyt Frederick , Vanfleteren Jan 
Published: October 2022

Abstract
This research presents an innovative method to accurately and repeatedly position electronic components in thermoformed electronics. The paper focuses on 3D shaped electronics, which are made up of stretchable metal structures integrated into thermoformable material. We used the degree of freedom theory to develop a design method that allows us to build the circuit in 2D in such a way that there is only one possible position for electronic components in the final 3D shape after thermoforming the sample. As a result, we have a reproducible design process for thermoformed electronics. We have assessed the result of the fabricated samples by measuring the 3D coordinates of the components on the 3D shaped design using a 3D scanner. The results proved that we have a repeatable component positioning methodology.
Projections of 21st century sea level rise for the coast of South Africa
Authors: Allison Lesley C , Palmer Matthew D , Haigh Ivan D 
Published: October 2022

Abstract
As a result of planetary heating, global mean sea level has increased since the end of the 19th century. Sea level rise is accelerating and will continue to rise over the 21st century and beyond. On top of the global mean signal there are large regional variations in the magnitude of sea level rise. At a local level, reliable projections of probable and possible future sea level change are vital for coastal management planning. In this work we present an observational analysis of recent sea level variations at locations around the coast of South Africa using tide gauge records and satellite altimetry data. In recent decades, sea level around South Africa has increased at a rate of around 3 mm year−1, consistent with estimates of global mean sea level rise over that time. We apply existing methods (that are rooted in the methods of the 5th Assessment Report of the Intergovernmental Panel on Climate Change, but with a number of methodological innovations) to produce sea level projections for eight locations around the coast of South Africa under low (RCP2.6) and high (RCP8.5) emissions scenarios. In the year 2100 locations around South Africa are projected to experience sea level rise (relative to 1986–2005) of approximately 0.5 m (0.25–0.8 m) following RCP2.6, or around 0.85 m (0.5–1.4 m) following RCP8.5. These increases are around 7%–14% larger than projections of global mean sea level, due to the local amplification of increases in several components of the sea level budget. The results from this work suggest that successful mitigation efforts to reduce greenhouse gas emissions would have a clear benefit in limiting 21st century sea level rise for South Africa.
Experimental study of quality respones during Gas metal arc welding in industrial welding robots by using Response surface method
Authors: Vignesh S , Udaiyakumar K C 
Published: October 2022

Abstract
Input parameters of GMAW can vary continuously at any point of time when used in an industrial welding robot and thus have a huge influence at output quality responses of the weld joint. In advent of welding automation, Industrial robots are used by most manufacturers to boost production rate & reduce operational cost. This publication tries to establish an optimum process parameter band for quality weld joint during continuous robot welding. To establish a relationship between both parameters RSM method has been used in an empirical approach. Input parameters of GMAW which are considered for this study are current, wirefeed rate and industrial robot arm speed, and the corresponding output response in form of weld bead geometry which defines the quality of the process. These all-input parameters have different effect on welding quality independent to each other. Stainless steel material (SUS409) has been used as experiment material.
Chemical transformer compression for accelerating both training and inference of molecular modeling
Authors: Yu Yi , Börjesson Karl 
Published: October 2022

Abstract
Transformer models have been developed in molecular science with excellent performance in applications including quantitative structure-activity relationship (QSAR) and virtual screening (VS). Compared with other types of models, however, they are large and need voluminous data for training, which results in a high hardware requirement to abridge time for both training and inference processes. In this work, cross-layer parameter sharing (CLPS), and knowledge distillation (KD) are used to reduce the sizes of transformers in molecular science. Both methods not only have competitive QSAR predictive performance as compared to the original BERT model, but also are more parameter efficient. Furthermore, by integrating CLPS and KD into a two-state chemical network, we introduce a new deep lite chemical transformer model, DeLiCaTe. DeLiCaTe accomplishes 4× faster rate for training and inference, due to a 10- and 3-times reduction of the number of parameters and layers, respectively. Meanwhile, the integrated model achieves comparable performance in QSAR and VS, because of capturing general-domain (basic structure) and task-specific knowledge (specific property prediction). Moreover, we anticipate that the model compression strategy provides a pathway to the creation of effective generative transformer models for organic drugs and material design.
Move–Bundle Connection in Conclusion Sections of Research Articles Across Disciplines
Authors: Deng Liming , Liu Jing 
Published: October 2022

Abstract
This study explores how lexical bundles link smaller functional units (steps) in research article (RA) conclusions in hard and soft science knowledge fields by using corpus-based and corpus-driven approaches. RA conclusion corpora from the hard and soft sciences were compiled and four-word lexical bundles were extracted from each corpus. Conclusions containing lexical bundles were then imported into the UAMCorpus tool for manual tagging of functions, structures, moves, and steps associated with lexical bundles. It has been found that the four-word bundles play an important role in realizing the communicative purpose of the functional units in RA conclusions in both the hard and soft sciences. The results demonstrate that the resultative lexical bundle (e.g. the findings of the) is a strong indicator of the conclusions in both soft and hard sciences. Specific bundle structures and functions are identified as signalling different steps of the conclusions. The findings of this study add to the growing body of knowledge regarding the bundle–move connections and contribute to the construction of the RA conclusions in different disciplinary cultures.
Left ventricular unloading with Impella versus IABP in patients on VA-ECMO for cardiogenic shock
Authors: Aggarwal D , Bhatia K , Lopez P , Bohra C , Joshi A , Daibes J , Mahmood K , Fox A 
Published: October 2022

Abstract

Background
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) use for circulatory support in shock is limited by increased left ventricular afterload. Impella and intra-aortic balloon pump (IABP) can be used in conjunction with VA-ECMO to help unload the left ventricle. Data comparing the two strategies are limited.

Purpose
We performed a systematic review and meta-analysis of published data to compare outcomes of patients with shock supported by VA-ECMO in conjunction with Impella versus IABP.

Methods
We conducted a search of Medline, Embase, and Cochrane databases to identify studies comparing the use of Impella versus IABP in patients on VA-ECMO. The primary outcome of interest was all-cause mortality (in-hospital or 30-day). Secondary outcomes included transition to destination therapy with left ventricular assist device (LVAD) or transplant, stroke, need for continuous renal replacement therapy (CRRT), bleeding, and hemolysis. Risk ratios (RR) with 95% confidence interval and the heterogeneity statistic I2 were reported for each outcome.

Results
Six observational studies with a total of 629 patients were included in the analysis. Of these, 205 (33%) and 424 (67%) patients were supported by Impella and IABP respectively, in addition to VA-ECMO. All six studies reported the primary outcome. No difference was observed in all-cause mortality between VA-ECMO with Impella and VA-ECMO with IABP (RR 1.02 [0.74–1.40], I2=74%). Similar rates were observed for transition to LVAD or transplant (RR 0.75 [0.45–1.27], I2=0%), stroke (RR 1.50 [0.80–2.83], I2=0%), and need for CRRT (RR 1.04 [0.82–1.32], I2=0%). However, use of VA-ECMO with Impella was associated with a higher risk of bleeding (RR 1.91 [1.28–2.86], I2=68%) and hemolysis (RR 4.61 [1.24–17.17], I2=66%) as compared with use of VA-ECMO with IABP.

Conclusion
In patients with shock requiring VA-ECMO, concurrent use of Impella and IABP had similar risk of mortality, transition to LVAD/transplant, stroke, and need for CRRT. However, Impella use was associated with higher risk of bleeding and hemolysis. Randomized trials are needed to identify the optimal strategy for left ventricular unloading in patients with cardiogenic shock on VA-ECMO.

Funding Acknowledgement
Type of funding sources: None.
Effect of supervised high-intensity interval training on haemostasis in patients with coronary artery disease: a randomised controlled trial
Authors: Kristiansen J , Grove E L , Sjurdarson T , Rasmussen J , Mohr M , Kristensen S D , Hvas A M 
Published: October 2022

Abstract

Background
Regular exercise training is recommended for patients with stable coronary artery disease (CAD), because it improves quality of life and reduces cardiovascular mortality and hospital admissions. CAD patients benefit from anti-thrombotic therapy and may have a pro-coagulant condition compared to healthy individuals. Long-term exercise training may reduce platelet aggregation and coagulation and increase fibrinolysis.

Purpose
We aimed to investigate if supervised high-intensity interval training affects haemostasis in patients with stable CAD.

Methods
We randomised stable CAD patients to supervised high-intensity interval training or standard care. High-intensity exercise training was performed on rowing ergometers three times weekly for 12 weeks. Blood samples were obtained in all patients prior to randomisation (baseline) and after 6 and 12 weeks. We evaluated platelet aggregation with the Multiplate® Analyzer, thrombin generation using the Calibrated Automated Thrombogram and fibrinolysis employing an in-house clot lysis assay. Between group differences were evaluated with mixed model analysis using SPSS. According to our sample size calculation, we have a statistical power of 88% to detect a difference of 25% in clot lysis time.

Results
A total of 142 patients with stable CAD (mean age 67±9 years, 83% males) completed the study; 64 in the exercise group and 78 in the control group. The weekly average active training duration was 54 min, and adherence to training was 97%. When comparing the two groups (exercise vs. standard care) from baseline to post intervention, we found no significant changes in ADP-induced platelet aggregation (difference between baseline and 12 weeks (Δ) 11 AU·min, 95% confidence interval (CI): −46–68 in the exercise group and Δ24 AU·min, 95% CI: −28–77 in the standard care group, p=0.52), thrombin generation (endogenous thrombin potential Δ45 nM·min, 95% CI: −77–166 in the exercise group and Δ103 nM·min, 95% CI: −7–212 in the standard care group, p=0.18) or fibrinolysis (50% clot lysis time Δ62 sec, 95% CI: −136–261 in the exercise group and Δ215 sec, 95% CI: 38–391 in the standard care group, p=0.39).

Conclusion
High-intensity interval training did not have major effects on platelet aggregation, thrombin generation nor fibrinolysis in patients with stable CAD.

Funding Acknowledgement
Type of funding sources: Public Institution(s). Main funding source(s): Aarhus UniversityThe Faroese Health Research Foundation (Sjúkrakassagrunnurin)
Media use and trust during the COVID-19 pandemic: evidence from eight cross-sectional surveys in Sweden
Authors: Winters Maike , Biermann Olivia , Bohlin Gustav , Bergman Martin , Brounéus Fredrik , Zeebari Zangin , Nordenstedt Helena 
Published: October 2022

Abstract

Background
While a lot has been written about Sweden’s COVID-19 control strategy, less is known about Swedish residents’ media use during the pandemic and trust in and perceived agreement among key stakeholders commenting in the media.

Methods
Eight online, nationwide surveys were fielded between March and August 2020, during the first wave of the coronavirus pandemic in Sweden, with 8146 responses. Questions were asked on media usage, perceived tone of media, trust in key pandemic stakeholder groups commenting in the media (politicians, journalists, government officials, doctors/healthcare professionals and researchers) and perceived agreement among these key stakeholders about how the pandemic was handled in Sweden.

Results
Using five or more information sources was associated with increased perceived alarmism in the media. Women and those with tertiary education were more likely to trust key pandemic actors. Trust in doctors/healthcare professionals and researchers remained high over the course of the study, trust in politicians and journalists was relatively low throughout the study period, with a slight increase in April 2020. Trust in key stakeholders was strongly associated with perceived agreement among the key stakeholders.

Conclusions
Our results show that trust in stakeholders was strongly associated with perceived consistency of messages from those stakeholders. The inverse also holds: perceived conflicting messages among stakeholders was associated with low trust in them. Taken together, this could point to the importance of building trust before a crisis. Trust-building efforts could be targeted to men and those with lower educational attainment, as they had lower trust in key stakeholders.
Revealing spatiotemporal dynamics of forest plantation harvesting practices at landscape level using satellite time series data
Authors: Cortés Lissette , Hernández Jaime 
Published: October 2022

AbstractForest landscapes dominated by commercial plantations are managed using intensive silvicultural schemes that involve a harvesting-replanting cycle, with clearcutting being one of the most used harvesting methods. Clearcutting has several negative effects, both biotic and abiotic, and to control them, many countries have established exclusion periods and restrictions regarding the amount and distribution of clearcutting areas at landscape level. However, Chile still does not have such restrictions. The main purpose of the study was to analyse forest area trends and to identify the spatiotemporal scales at which clustering of clearcutting areas occurred, between 1999 and 2017. The study area was the coastal zone of the Region of Maule, Chile, dominated by Monterey pine (Pinus radiate D. Don) plantations. We used Landsat 5, 7 and 8 to produce yearly land cover maps to differentiate clearcutting areas from other classes. By using Emerging Hot Spot Analysis, we calculated the spatiotemporal trends of these clearcut areas. We found that harvest clusters have an oscillatory behaviour, ranging from Hot to Cold Spots over the time with an average size of 46.8 km2 and being active for 2 years (±1.7). Our results support the claim to introduce new regulations to the current Chilean legislation regarding explicit exclusion periods and multiscale forest management.
Induction of Remission With Exclusive Enteral Nutrition in Children With Crohn’s Disease: Determinants of Higher Adherence and Response
Authors: Cuomo Marialaura , Carobbio Alessandra , Aloi Marina , Alvisi Patrizia , Banzato Claudia , Bosa Luca , Bramuzzo Matteo , Campanozzi Angelo , Catassi Giulia , D’Antiga Lorenzo , Di Paola Monica , Felici Enrico , Fioretti Maria Teresa , Gatti Simona , Graziano Francesco , Lega Sara , Lionetti Paolo , Marseglia Antonio , Martinelli Massimo , Musto Francesca , Sansotta Naire , Scarallo Luca , Zuin Giovanna , Norsa Lorenzo 
Published: October 2022

Abstract

Background
Exclusive enteral nutrition (EEN) is the first choice to induce remission and promote mucosal healing in pediatric Crohn’s disease (CD). However, full adherence to EEN treatment may be problematic for children with CD.

Methods
The goal of the current multicenter retrospective study was to define predictive factors of nonadherence to treatment and nonremission at the end of induction treatment. Those data together were analyzed with the ultimate goal of trying to define an individualized induction treatment for children with CD.

Results
Three hundred seventy-six children with CD from 14 IBD pediatric referral centers were enrolled in the study. The rate of EEN adherence was 89%. Colonic involvement and fecal calprotectin &gt;600 μg/g at diagnosis were found to be associated with a reduced EEN adherence. Exclusive enteral nutrition administered for 8 weeks was effective for inducing clinical remission in 67% of the total cohort. Factors determining lower remission rates were age &gt;15 years and Pediatric Crohn’s Disease Activity Index &gt;50.

Conclusion
Although EEN is extremely effective in promoting disease remission, several patients’ related factors may adversely impact EEN adherence and response. Personalized treatments should be proposed that weigh benefits and risks based on the patient’s disease location, phenotype, and disease activity and aim to promote a rapid control of inflammation to reduce long-term bowel damage.
Poisson Generic Sequences
Authors: Álvarez Nicolás , Becher Verónica , Mereb Martín 
Published: October 2022

Abstract
Years ago, Zeev Rudnick defined the Poisson generic real numbers by counting the number of occurrences of long blocks of digits in the initial segments of the expansions of the real numbers in a fixed integer base. Peres and Weiss proved that almost all real numbers, with respect to the Lebesgue measure, are Poisson generic, but they did not publish their proof. In this note, we first transcribe Peres and Weiss’ proof and then we show that there are computable Poisson generic instances and that all Martin–Löf random real numbers are Poisson generic.
Effects of glucose availability on αS1-casein synthesis in bovine mammary epithelial cells
Authors: Sun Mei , Li Zinan , Xing Yuanyuan , Mu Xiaojia , Cao Yue , Hao Yihong , Yang Jing , Li Dabiao 
Published: October 2022

Abstract
Glucose has been demonstrated to affect milk protein synthesis in dairy cows. However, its potential mechanisms has not been thoroughly studied. The objective of this study was to investigate the effects of glucose availability on αS1-casein synthesis, glucose uptake, metabolism, and the expression of proteins involved in AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) signaling pathway in bovine mammary epithelial cells (BMEC). BMEC were treated for 24 h with different concentrations of glucose (0, 7, 10.5, 14, 17.5, and 21 mM). The results showed that 10.5 and 14 mM glucose supply increased the expression of αS1-casein, glucose uptake, cellular ATP content, and the phosphorylation of mTOR and P70S6K, but repressed AMPK phosphorylation in BMEC. Compared with 10.5 and 14 mM glucose supply, 17.5 and 21 mM glucose decreased the expression of αS1-casein, P70S6K phosphorylation as well as the activity of hexokinase (HK) and pyruvate kinase (PK), but increased the activity of glucose-6-phosphate dehydrogenase (G6PD). These results indicate that 10.5 to 14 mM glucose supply is the proper range for αS1-casein synthesis, and the promotion effects may be related to the increase of glucose uptake, ATP content and the changes of key proteins’ phosphorylation in AMPK/mTOR signaling pathway. However, the inhibition of the expression of αS1-casein by 17.5 and 21 mM glucose may be associated with the changes of key enzymes’ activity involved in glucose metabolism.
Physiological Signatures of Changes in Honeybee’s Central Complex During Wing Flapping
Authors: Ding Haojia , Yan Shaoze 
Published: October 2022

Abstract
Many kinds of locomotion abilities of insects-including flight control, spatial orientation memory, position memory, angle information integration, and polarized light guidance are considered to be related to the central complex. However, evidence was still not sufficient to support those conclusions from the aspect of neural basis. For the locomotion form of wing flapping, little is known about the patterns of changes in brain activity of the central complex during movement. Here, we analyze the changes in honeybees’ neuronal population firing activity of central complex and optic lobes with the perspectives of energy and nonlinear changes. Although the specific function of the central complex remains unknown, evidence suggests that its neural activities change remarkably during wing flapping and its delta rhythm is dominative. Together, our data reveal that the firing activity of some of the neuronal populations of the optic lobe shows reduction in complexity during wing flapping. Elucidating the brain activity changes during a flapping period of insects promotes our understanding of the neuro-mechanisms of insect locomotor control, thus can inspire the fine control of insect cyborgs.
Study on supercritical methane flow and heat transfer performance in a 180-degree curved duct
Authors: Han Changliang , Duan Jingying , Yin Sibei , Li Xibing 
Published: October 2022

ABSTRACT
In this paper, an investigation into flow and heat transfer performance of supercritical methane (S-CH4) in a 180-degree curved circular duct has been numerically carried out. The mathematical description of energy equation induced by the Dean vortices under the Cartesian-coordinate is first deduced. After validating the dynamic computational fluid dynamics model and method against the public experimental data, the effect of mass flux on the thermodynamics properties of S-CH4 is revealed. The calculation results show that due to the centrifugal force, the low temperature of S-CH4 gathers near the outer wall generatrix. Meanwhile, owing to the existence of multiple Dean vortices, all thermophysical parameters on the 90° cross-section are symmetrically concave along the vertical axis. The core position of multiple Dean vortices inside the curved duct is closer to the inner wall generatrix, which makes the velocity fluctuation greater. The maximum value of circumferential heat transfer coefficient on different cross-sections differs, and the non-uniform flow development process occurs inside the curved duct. Compared to the straight duct, when the mass fluxes are respectively 300 kg/m2 · s and 600 kg/m2 · s, the magnitude of increase in heat transfer coefficient of curved duct presents 18.8% and 23.5%. In addition, the forced convection caused by the secondary flow inside curved duct is so strong that the natural convection by the gravity could be neglected. The research outcome is of vital importance for the optimization design of liquefied natural gas vaporizer.