bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency of arrythmia depending on the severity of the functional class in patients with metabolic syndrome and heart failure
Authors: Kurbanova D. K. , Dashdamirov R. L. 
Published: March 2022

Study objective: to study the incidence of arrhythmias in patients with metabolic syndrome and heart failure in accordance with the severity of the functional class (1964, according to the NYNA classification).Materials and methods: The study included 90 patients with heart failure (HF) II and III functional class (FC), EF<50% and metabolic syndrome, who received outpatient and inpatient treatment at the J. Abdullaeva Scientific Researh Institute. Among the patients, 57 were with HF II (according to the NYNA classification), and 33 were with HF III functional class. The age of the patients ranged from 36 to 88 years. Of these, 27% were women, 63% were men. The patients underwent complex clinical, instrumental and laboratory examinations. Instrumental examinations included daily monitoring of the electrocardiogram by the Holter method (with CONTEC, TLC 5000), 6-minute walking test, blood ion analysis, MS indicators, and lipid spectrum research. Exclusion criteria were chronic obstructive pulmonary disease, bronchial asthma, cardiomyopathies,heart defects.Results: The incidence of ventricular premature beats (especially in an amount greater than 1000) among patients with heart failure of the III functional class (97.0%) is slightly higher than in patients of the II functional class (91.2%). However, supraventricular premature beats are more common (78.9%) in patients with functional class II heart failure than in functional class III patients (57.6%). Atrial fibrillation in patients with heart failure of functional class III (33.3%) occurs approximately 1.7 times more often than in patients of functional class II (19.3%). Almost the same frequency of occurrence of episodes of sinus rhythm and atrial fibrillation were observed. Shortterm ventricular tachycardia was recorded in 2 patients of functional class III.Conclusions: In patients with metabolic syndrome, the incidence of ventricular premature beats and atrial fibrillation correlate with the functional class of heart failure, and episodes of ventricular tachycardia are also observed.
Gradual Sequestration of Water at Lunar Polar Conditions due to Temperature Cycles
Authors: Schorghofer Norbert 
Published: March 2022

Abstract
Migration of water molecules into the porous lunar soil can lead to sequestration of adsorbed water or ice at depth. Here, this process is modeled at several potential landing sites in the south polar region of the Moon. Desorption times are parameterized based on the Brunauer–Emmett–Teller (BET) isotherm model. Water sequestration is significant at depths where subsurface temperatures remain below the cold-trapping threshold, a condition satisfied at one of three sites considered, west of Haworth Crater. Model calculations predict a hydrated layer below a desiccated layer. The thickness of the desiccated layer is on the scale of the thermal skin depth, which for dust is typically centimeters. The underlying layer, decimeters thick, can be hydrated over a timescale of a billion years, reaching abundances on the order of 1 wt%. This sequestration process potentially simultaneously explains excess hydrogen concentrations outside of cold traps and the observed presence of a desiccated layer above a hydrogenous layer.
Possible TeV Gamma-Ray Binary Origin of HESS J1828–099
Authors: De Sarkar Agnibha , Roy Nirupam , Majumdar Pratik , Gupta Nayantara , Brunthaler Andreas , Menten Karl M. , Dzib Sergio A. , X. Medina Sac Nicté , Wyrowski Friedrich 
Published: March 2022

Abstract
The High Energy Stereoscopic System (H.E.S.S.) observatory has carried out a deep survey of the Galactic plane, in the course of which the existence of a significant number of (∼78) TeV γ-ray sources was confirmed, many of which remain unidentified. HESS J1828–099 is a point-like (Gaussian standard deviation < 0.°07) unidentified source among the 17 confirmed point-like sources in the H.E.S.S. Galactic Plane Survey (HGPS) catalog. This source is also unique because it does not seem to have any apparent association with any object detected at other wavelengths. We investigate the nature and association of HESS J1828–099 with multiwavelength observational data. A high-mass X-ray binary (HMXB)—composed of the pulsar XTE J1829–098 and a companion Be star—has been observed earlier in the X-ray and infrared bands, 14′ away from HESS J1828–099. With 12 yr of Fermi-LAT γ-ray data, we explore the possibility of 4FGL J1830.2–1005 being the GeV counterpart of HESS J1828–099. Within the RXTE confidence region, a steep-spectrum (α
radio = −0.746 ± 0.284) plausible counterpart is detected in data from existing radio frequency surveys. In this Letter, we probe for the first time, using multiwavelength data, whether HESS J1828–099, 4FGL J1830.2–1005, and the HMXB system have a common origin. Our study indicates that HESS J1828–099 might be a TeV high-mass γ-ray binary source.
Tidal Dissipation Due to Inertial Waves Can Explain the Circularization Periods of Solar-type Binaries
Authors: Barker Adrian J. 
Published: March 2022

Abstract
Tidal dissipation is responsible for circularizing the orbits and synchronizing the spins of solar-type close binary stars, but the mechanisms responsible are not fully understood. Previous work has indicated that significant enhancements to the theoretically predicted tidal dissipation rates are required to explain the observed circularization periods (P
circ) in various stellar populations and their evolution with age. This was based partly on the common belief that the dominant mechanism of tidal dissipation in solar-type stars is turbulent viscosity acting on equilibrium tides in convective envelopes. In this paper, we study tidal dissipation in both convection and radiation zones of rotating solar-type stars following their evolution. We study equilibrium tide dissipation, incorporating a frequency-dependent effective viscosity motivated by the latest hydrodynamical simulations, and inertial wave (dynamical tide) dissipation, adopting a frequency-averaged formalism that accounts for the realistic structure of the star. We demonstrate that the observed binary circularization periods can be explained by inertial wave (dynamical tide) dissipation in convective envelopes. This mechanism is particularly efficient during pre-main-sequence phases, but it also operates on the main sequence if the spin is close to synchronism. The predicted P
circ due to this mechanism increases with the main-sequence age in accordance with observations. We also demonstrate that both equilibrium tide and internal gravity-wave dissipation are unlikely to explain the observed P
circ, even during the pre-main sequence, based on our best current understanding of these mechanisms. Finally, we advocate more realistic dynamical studies of stellar populations that employ tidal dissipation due to inertial waves.
The use of literature as a veritable instrument for the teaching of English language
Authors: Ekhator Itohan Ethel , Aihevba Peter Oghogho 
Published: March 2022

This article discusses the use of literature as a popular tool for teaching basic language skills such as reading, writing, listening and speaking and other language areas such as vocabulary, grammar and pronunciation in English as a Second Language classroom. It uses the literary method in its analysis of the Nigerian situation. The reasons and criteria for selecting literary texts are discussed. Also the benefits of different genres of literature such as poetry, short fiction, drama and novel to language teaching are taken into account. The paper recognized that all genres should be carefully selected and used in the teaching of English Language skills and language skills should not be taught in isolation.
Costus speciosus J Koenig (Costaceae) exerts anti-proliferative effect on breast cancer cells via induction of cell cycle arrest and inhibition of activity of metalloproteinase-2
Authors: Bawakid Nahed O. , Abdel-Lateff Ahmed , El-Senduny Fardous F. , Alarif Walied M. 
Published: March 2022

Purpose: To Investigate the antiproliferative effect of n-hexane-diethyl ether fraction of Costus speciosus (NP) on triple negative breast cancer (MDA-MB-231) cells, and the mechanism involved.
Methods: Maceration with methanol (CH3OH) was used for extraction of Costus speciosus rhizomes. Chromatographic separation was used to obtain the non-polar fraction (NP) via elution with n-hexane:(C2H5)2O at a volume ratio of 9:1. The cytotoxic effect of NP was evaluated against two breast cancer cell lines i.e., triple negative (MDA-MB-231) and positive ER (MCF-7) employing 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT) assay, and the IC50 values were estimated. Cell cycle was determined with flow cytometry, while the likely mechanism involved in the cytotoxic effect was investigated using comet assay, immunofluorescence, clonogenic and scratch assays, zymography and detection of the antioxidant markers.
Results: NP produced potent cytotoxicity against MDA-MB-231, with IC50 value of 4 ± 0.03 μg/mL, whereas its IC50 for MCF-7 was 27 ± 1.3 μg/mL. It induced apoptosis via cell cycle arrest at G1 phase. Moreover, NP markedly decreased levels of superoxide dismutase (SOD), reduced glutathione (GSH), and matrix metalloprotease-2 (MMP-2), in MDA-MB-231 cells. Moreover, it inhibited cancer cell migration and colony formation.
Conclusion: Non-polar fraction of Costus speciosus (NP) exerted cytotoxic effect on triple negative breast cancer cells (MDA-MB-231) and positive ER (MCF-7). It inhibited cancer cell migration and colony formation. Interestingly, NP arrested the breast cancer cell cycles at sub-G1 phase, inhibited SOD and MMP-2, and decreased GSH levels. It induced apoptosis via DNA damage, downregulation of mutant p53, and over-expressions of the cell cycle inhibitors p21 and p27.
Model statistic regional pentru estimarea diametrului de bază al molidului în funcție de diametrul cioatei la înălțimea de referință de 30 cm
Authors: Popa Ionel , Popa Andrei , Horvath Arnold , Ștețco Istrate , Korpos Attila 
Published: March 2022

În practica silvică adeseori se impune estimarea diametrului de bază și a volumului arborilor pornind de la diametrul cioatei rămase după extragere. Elaborarea de tabele dendrometrice locale privind derivarea diametrului de bază funcție de diametrul cioatei reprezintă o necesitate pentru administrația silvică. În prezentul studiu s-a calibrat un model regresiv local, de tip parabolic cu modelarea varianței reziduale, pentru obținerea diametrului de bază la molid funcție de diametrul cioate cu înălțimea de 30 cm, reprezentativ pentru fondul forestier administrat de Ocolul silvic de regim Gheorgheni. Setul de date utilizat pentru estimarea parametrilor modelului statistic este format din 4050 de arbori din 111 arborete, cu caracteristici biometrice variate. Modelul statistic propus și volumele unitare diferențiate pe clase de producție permite o evaluarea mai corectă a pagubelor provenite din tăieri ilegale, având o fiabilitate ridicată în condițiile fondului forestier administrat de OSR Gheorgheni.
Academicianul Victor Giurgiu și contribuția sa la dezvoltarea învățământului universitar silvic din Bucovina
Authors: Horodnic Sergiu Andrei , Roibu Cătălin-Constantin 
Published: March 2022

Profesorul universitar Victor Giurgiu, cu o remarcabilă şi prolifică activitate prin ştiinţă şi pentru știință, a fost unul din cei mai aprigi promotori și susținători ai calității actului didactic și ai cercetării științifice autentice. La începutul anilor ’90, academicianul Victor Giurgiu a contribuit definitoriu la crearea şi dezvoltarea şcolii silvice superioare în proaspăt înfiinţata universitate suceveană.
Sunt subliniate cele mai reprezentative contribuţii ale domnului academician Victor Giurgiu, în măsură să contureze personalitatea sa ştiinţifică şi academică, însoţite de prezentarea câtorva repere biografice.
Lucrarea este un omagiu încărcat de recunoştinţă al întregului colectiv al Facultăţii de Silvicultură din Suceava a cărei evoluţie a fost puternic marcată de activitatea distinsului magistru.
Comparison of Ki-67 index values between patients with operated giant prolactinomas and macroprolactinomas
Authors: CANDER Soner , ÖZ GÜL Özen 
Published: March 2022

Objective: Data on whether there is a histopathological difference in cellular features as determined with Ki-67 between giant prolactinomas and smaller macroprolactinomas are not fully clear. In this study, we aimed to compare Ki-67 value between patients followed-up with diagnosis of macroprolactinoma and giant prolactinoma and operated for different reasons.
Methods: Files of 15 patients with giant prolactinomas and 16 patients with macroprolactinomas who had been operated with various indications were retrospectively evaluated. Similar number of patients were included to carry out a reasonable analysis. Patients’ demographics (age and gender), age at the time of diagnosis, tumor diameter during the diagnosis and at the last follow-up visit, initial and last PRL and Ki-67 values were compared between the groups. Ki-67 value was studied with MIB-1 monoclonal antibody method.
Results: The mean age and gender were similar between the patients with macroprolactinomas and giant prolactinomas. The mean longest tumor diameter at diagnosis was measured as 18.13±9.42 mm in the macroprolactinoma and 47.07±9.70 mm in the giant prolactinoma group (p
Evaluation of Patients Performed with Saline Infusion Test with a Pre-Diagnosis of Primary Hyperaldosteronism
Authors: ATEŞ Coşkun , ADA Gül , MERCAN SARIDAŞ Filiz , AYDEMİR Ensar , HOCAOĞLU Erhan , ÖZ GÜL Özen , CANDER Soner , ERSOY Canan , ERTÜRK Erdinç 
Published: March 2022

Background: Primary hyperaldosteronism (PHA) is a primarily treatable cause of arterial hypertension characterized by low plasma renin and high aldosterone levels. The prevalence of secondary hypertension as a common endocrine cause is 5-13%. The plasma aldosterone/renin ratio (ARR) is the best available method for PHA screening. One or more confirmatory tests may be required to confirm or exclude patients' diagnoses. One frequently used confirmatory test is the saline infusion test (SİT). We aimed to screen the patients who underwent SİT with the preliminary diagnosis of PHA and to compare the results of the patients diagnosed with essential hypertension (EH) and PHA.
Material and Methods: Seventy-seven patients with a history of drug-resistant hypertension or unexplained spontaneous or diuretic-induced hypokalemia or adrenal incidentaloma, or a family history of early-onset hypertension or cerebrovascular accident at a young age (0.05). Basal plasma aldosterone (p
Retrospective evaluation of radioactive iodine ablation therapy in the Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) and Thyroid tumors with uncertain malignity potential
Authors: GÖKTUĞ Mehmet Refik , ÖZ GÜL Özen , CANDER Soner 
Published: March 2022

Background: Noninvasive Follicular Thyroid Neoplasm (NIFTP), Well differantiated thyroid tumor with uncertain malignity potential (WDT-UMP), follicular thyroid tumor with uncertain malignity potential (FT-UMP), and Hurtle cell neoplasia with uncertain malignity potential (HCN-UMP) have been included in the classification of thyroid tumors by WHO, with the incidence of thyroid cancer increasing every passing year. There is no consensus regarding the follow-up and treatment processes of these tumors. Our study aims to shed light on our clinical practice by evaluating the follow-up processes of the groups with and without radioactive iodine ablation in patients followed up with these diagnoses.
Material and Methods: The 49 patients older than 18 years of age and followed for at least 12 months, who were performed subtotal and total thyroidectomy between 2015 and 2020 and were diagnosed with WDT- UMP, FT-UMP, HCN-UMP, and NIFTP according to histopathological examination were included to the study.
Results: Tumor type rates did not differ between the groups that received and did not receive RAI treatment (p=0.361). The mean follow-up period did not differ between the groups that received and did not receive RAI treatment. Also the rates of RAI treatment according to tumor size did not differ (p=0.413). Tumor size was larger than 4 cm in 13 patients, and 1 patient from this group had received RAI treatment. Recurrence was not detected in the 49 patients included in our study who received or not receive RAI treatment.
Conclusions: Some studies recommend giving RAI to these borderline thyroid tumors larger than 4 cm. But in our study no recurrence was detected in patients who did not receive RAI. That supports the view that patients could be followed without RAI treatment even if they are large tumors.
A Single Center Retrospective Analysis of Patients with Recurrent Papillary Thyroid Carcinoma Undergoing Radiofrequency Ablation
Authors: HOCAOĞLU Erhan , AYDEMİR Ensar , ATEŞ Coşkun , MERCAN SARIDAŞ Filiz , NAS Omer Fatih , İNECİKLİ Mehmet Fatih , CANDER Soner , ÖZ GÜL Özen , ERTÜRK Erdinç , ERSOY Canan 
Published: March 2022

Background: Radiofrequency ablation (RFA) is used in selected patients with recurrent or metastatic thyroid cancer who have high surgical risk or do not accept surgical treatment. However, long-term follow-up data are limited. Here, we present our single-center experience with the use of RFA in the treatment of recurrent or metastatic papillary thyroid carcinoma (PTC).
Material and Methods: Patients who underwent RFA for recurrent or metastatic PTC at Bursa Uludag University Faculty of Medicine between September 2014 and January 2021 were included. The data in the endocrinology outpatient clinic follow-ups of the patients were analyzed retrospectively.
Results: A total of 10 patients, 11 RFA procedures, and 13 residual or metastatic sites were evaluated. The mean age was 44.50±14.04 years. The mean largest diameter of the tumor in which RFA was applied was 11.85±5.95 mm. Patients developed no major complications. Two patients experienced minor complications. The mean follow-up duration was of 51.20±19.86 months. During the follow-up period, 12 (92.30%) of 13 RFA sites completely disappeared. In one patient (7.69%) residual tumor tissue was detected after RFA. There was no recurrence at the procedure site. A significant decrease was found in the largest diameter of the treated regions after RFA (p=0.002). Thyroglobulin and anti-thyroglobulin levels were not significantly different before and after RFA (p=0.44 and p=1.00, respectively).
Conclusions: RFA is highly effective and safe for locally recurrent PTC. It shows promise as an alternative to surgery to control locoregional recurrence of PTC.
Comparison of Clinical Progress of Covid-19 Patients Followed in the Hospital by Vaccination Status
Authors: YİĞİT Sidelya Ecem , GÖKMEN İffet Beril , OKUTURLAR Yıldız , KÖKSAL İftihar 
Published: March 2022

Background: Although Covid-19 vaccines cannot prevent infection with SARS-CoV-2, they do allow infected people to have a milder illness. In unvaccinated people, the disease progresses more severely and the disease can be fatal. Both inactivated (Sinovac) and mRNA (Biontech-Pfizer) vaccines are used in Turkey. In this retrospective study, clinical course, radiological involvement and some laboratory parameters that are important for Covid-19 were compared in unvaccinated and vaccinated patients who were infected and followed up in the hospital.
Material and methods: Patients between the ages of 17-95 who were hospitalized in the Covid-19 isolation wards between June 2021 and November 2021 were included in the study. Various datas of patients were scanned retrospectively from the hospital registry system.
Results: While there was no difference in the mean age, highest fibrinogen, D-dimer, ferritin, creatinine, interleukin-6 (IL6) values and Covid-19 PCR test negative times besides antibody levels, Group 2 (7.8 days) was found to be discharged significantly earlier than Group 1 (12.69 days) (p=0.046). There was a significant difference in low-dose thoracic computed tomography (CT) findings between the two groups (p= 0.023).
Discussion: Our study results showed that regardless of the type of vaccine, vaccination against Covid-19 reduces hospitalization rates, length of stay and prevents serious involvement in the lungs.
Medication Errors and Potentially Inappropriate Medication Use in Elderly Patients Admitted to the General Internal Medicine Outpatient Clinic of a University Hospital
Authors: PESEN Ercan , DEMİRCAN Celaleddin , SIĞIRLI Deniz 
Published: March 2022

Background: The frequency of chronic diseases, number of drugs used, and number of medication errors have increased in the elderly. In this study, we aimed to determine the prevalence of potentially inappropriate medication (PIM) use and medication errors in elderly patients admitted to a university hospital and to identify the influencing factors.
Material and Methods: In this prospective cross-sectional study, the patients’ characteristics, drug use patterns, and medication errors in the previous month were recorded in detail. Following this, PIM use was assessed according to the 2015 Beers Criteria.
Results: A total of 721 elderlay patients (60.9% female and 39.1% male) were included in this study. The mean number of drugs used by the patients per day was 4.6±2.8 and the rate of polypharmacy was 49.4%. The rate of medication errors was 54.2%, that of PIM use was 30.1%, and that of adverse drug reactions was 22.5%; these rates were higher in patients with polypharmacy. The most common medication error, PIM use, and adverse drug reaction were the omission of a daily dose (36.5%), inappropriate use of proton pump inhibitors (10%), and gastrointestinal system-related symptoms (7.7%), respectively. Diabetes mellitus and depression were found to be independent factors associated with medication errors.
Conclusions: In the present study, patient-related medication errors, PIM use, and adverse drug reactions were more frequently observed in elderly patients with polypharmacy. In addition, medication errors were more commonly observed in elderly with diabetes mellitus and depression.
Radiotherapy could increase the efficacy of immunotherapy in non-small cell lung cancer
Authors: OCAK Birol , SARIHAN Süreyya , ŞAHİN Ahmet Bilgehan , DAKİKİ Bahar , CANER Burcu , GÜLŞEN Kemal , TANRIVERDİ Özgür , DELİGÖNÜL Adem , ÇUBUKÇU Erdem , EVRENSEL Türkkan 
Published: March 2022

Background: In non-small cell lung cancer (NSCLC), immunotherapy is a treatment option in patients without targetable mutations in second and later lines. Nevertheless, there is no validated test that can predict immunotherapy response.
Material and Methods: Our study aimed to investigate the effect of radiotherapy (RT) on survival in patients with NSCLC receiving immunotherapy after first-line chemotherapy. Twenty-five patients diagnosed with NSCLC and received immunotherapy after at least one previous chemotherapy line were included in our study.
Results: The median age of the patients was 61.7 (26.6-81.2) years. 19 (76%) patients were male. 11 (44%) of the patients had received immunotherapy in the second-line and 14 (66%) in ≥3 lines. Patients had received a median of 5 cycles (1-27) of immunotherapy. RT to immunotherapy interval was 6.4 months (1.0-11.8). Partial response was observed in 12 patients, stable disease in 8 patients, progression in 1 patient, and hyperprogression in 4 patients. Median progression-free survival (PFS) was 4.4 months (95% CI; 3.2-5.6), and median overall survival (OS) was 16.4 months (95% CI; 5.6-27.3). 14 (56%) of the patients had received RT. RT was administered to 12 patients before immunotherapy, and two patients received RT to bones during immunotherapy. The patients who received RT had statistically longer PFS (4.9 vs 3.9 months, p=0.012) and OS (18.7 vs 7.3 months, p=0.023) comparing those without RT.
Conclusions: Our findings showed that RT significantly improved the survival in patients who received immunotherapy, pointing that RT may have an influential role in immunotherapy response.