bluuebunny/crossref_metadata_2025_split huggingface dataset:
Withdrawal Notice: MgAl2O4 Spinel-type as Highly Efficient Catalyst for One-pot Synthesis of 4H-pyrans
Authors: Dib Mustapha , Kacem Marieme , Talbi Soumaya , Ouchetto Hajiba , Ouchetto Khadija , Essoumhi Abdellatif , Hafid Abderrafia , Khouili Mostafa 
Published: January 2022

The article has been withdrawn at the request of the editor of the journal Current Chemical Biology due to incoherent content.

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The Method of Predicting the Maintenance Time of Mechanical Products
Based on Virtual Prototype
Authors: Li Jin , Jiang Xinsheng , Wang Zituo , Wang Chunhui , Cai Yunxiong 
Published: January 2022

Aim:
This study aimed to predict the mechanical product maintenance time in the absence of
a physical prototype or similar product statistics throughout the design stage.

Method:
According to the theory of time accumulative estimation method, a product maintenance time
prediction method framework based on a virtual prototype was constructed, which described the prediction
process. The virtual maintenance environment containing virtual prototype, virtual human, and
maintenance tools was developed. The virtual human’s position and posture information during the
maintenance process was obtained by implementing VBScript language.

Result:
Basic maintenance motions that constitute the whole maintenance process were classified into
4 categories: body movement, upper limb movement, grasp/replace, and operation. Based on
MODAPTS (modular arrangement of predetermined time standard) method and virtual maintenance
simulation, corresponding time prediction methods for each categories were proposed.

Discussion:
Taking a maintenance dissassembly and assembly task of engine as an example, through
the comparison between the measured actual maintenance time and predicted time of several methods,
feasibility and effectiveness of proposed method are verified.
Evaluation of a Web-Based Medication Reconciliation Application Within a Primary Care Setting: Cluster-Randomized Controlled Trial
Authors: Gionfriddo Michael R , Hu Yirui , Maddineni Bhumika , Kern Melissa , Hayduk Vanessa , Kaledas William R , Elder Nevan , Border Jeffrey , Frusciante Katie , Kobylinski Maria , Wright Eric A 
Published: January 2022

Background
Despite routine review of medication lists during patient encounters, patients’ medication lists are often incomplete and not reflective of actual medication use. Contributing to this situation is the challenge of reconciling medication information from existing health records, along with external locations (eg, pharmacies, other provider/hospital records, and care facilities) and patient-reported use. Advances in the interoperability and digital collection of information provides a foundation for integration of these once disparate information sources.

Objective
We aim to evaluate the effectiveness of and satisfaction with an electronic health record (EHR)-integrated web-based medication reconciliation application, MedTrue (MT).

Methods
We conducted a cluster-randomized controlled trial of MT in 6 primary care clinics within an integrated health care delivery system. Our primary outcome was medication list accuracy, as determined by a pharmacist-collected best-possible medication history (BPMH). Patient and staff perspectives were evaluated through surveys and semistructured interviews.

Results
Overall, 224 patients were recruited and underwent a BPMH with the pharmacist (n=118 [52.7%] usual care [UC], n=106 [47.3%] MT). For our primary outcome of medication list accuracy, 8 (7.5%) patients in the MT arm and 9 (7.6%) in the UC arm had 0 discrepancies (odds ratio=1.01, 95% CI 0.38-2.72, P=.98). The most common discrepancy identified was patients reporting no longer taking a medication (UC mean 2.48 vs MT mean 2.58, P=.21). Patients found MT easy to use and on average would highly recommend MT (average net promoter score=8/10). Staff found MT beneficial but difficult to implement.

Conclusions
The use of a web-based application integrated into the EHR which combines EHR, patient-reported data, and pharmacy-dispensed data did not improve medication list accuracy among a population of primary care patients compared to UC but was well received by patients. Future studies should address the limitations of the current application and assess whether improved implementation strategies would impact the effectiveness of the application.
Does off-hours endoscopic hemostasis affect outcomes of nonvariceal upper gastrointestinal bleeding?
Authors: Guan Jia-Lun , Wang Ge , Fang Dan , Han Ying-Ying , Wang Mu-Ru , Tian De-An , Li Pei-Yuan 
Published: January 2022

Aim:
Different researches showed controversial results about the ‘off-hours effect’ in nonvariceal upper gastrointestinal bleeding (NVUGIB).
Materials & methods:
A total of 301 patients with NVUGIB were divided into regular-hours group and off-hours group based on when they received endoscopic hemostasis, and the relationship of the clinical outcomes with off-hours endoscopic hemostasis was evaluated.
Results:
Patients who received off-hours endoscopy were sicker and more likely to experience worse clinical outcomes. Off-hours endoscopic hemostasis was a significant predictor of the composite outcome in higher-risk patients (adjusted OR: 4.63; 95% CI: 1.35–15.90). However, it did not associate with the outcomes in lower-risk patients.
Conclusion:
Off-hours effect may affect outcomes of higher-risk NVUGIB patients receiving endoscopic hemostasis (GBS ≥12).
Kadar 8-Oxo-7, 8-Dihydro-2’-Deoxyguanosine (8-Oxo-Dgsn) Dalam Urine Sebagai Biomarker Penuaan Pada Pasien Tb Paru
Authors: Wijaya Cathrine Meryani , Santoso Arif , Hamid Firdaus , As’ad Suryani , Bukhari Agussalim , Zainuddin Alfian 
Published: January 2022

Proses penuaan merupakan proses fisiologis yang tidak dapat dihindari. Pengukuran 8-oxo-dGsn dalam urin berpotensi sebagai cara baru untuk mengevaluasi proses penuaan dalam menentukan dan memperkirakan usia fisiologis. Penelitian ini betujuan untuk mengetahui kadar 8-Hydroxy-deoxyguanosine (8-OHdG) dalam urin sebagai biomarker penuaan pada pasien tuberculosis paru. Penelitian ini menggunakan pendekatan case control yakni penderita TB paru sebagai kelompok kasus dan kelompok orang sehat sebagai control dengan jumlah sampel sebanyak 50 orang (25 orang kasus dan 25 orang kontrol). Data dianalisis dengan menggunakan SPSS 21.0 (SPSS, Inc. Chicago, IL) dengan tingkat kemaknaan α=0.05.Hasil penelitian menunjukkan bahwa Kadar 8-Hydroxy-deoxyguanosine (8-OHdG) dalam urin sebagai biomarker penuaan pada kelompok kasus rata-rata 3.21±0.88. Kadar 8-Hydroxy-deoxyguanosine (8-OHdG) dalam urin sebagai biomarker penuaan pada kelompok kontrol rata-rata 2.38±0.71. Ada korelasi positif antara umur dengan kadar 8-Hydroxy-deoxyguanosine (8-OHdG) dalam urin sebagai biomarker penuaan (p < 0,001), dimana semakin bertambah umur maka kadar 8-Hydroxy-deoxyguanosine (8-OHdG) semakin tinggi. Terdapat perbedaan yang bermakna (p:0.001) secara statistik kadar 8-Hydroxy-deoxyguanosine (8-OHdG) sebagai biomarker penuaan antara kelompok kasus dengan kelompok kontrol. Kesimpulan penelitian ini adalah Tuberculosis paru mempercepat proses penuaan yang ditandai dengan peningkatan kadar 8-Hydroxy-deoxyguanosine (8-OHdG) dalam urine sebagai biomarker penuaan.
Karakteristik Gempa Foreshock dan Aftershock Pada Sumber Gempa Intraplate Berdasar Distribusi Kejadain Gempa (Studi Kasus: Gempa Padang 2009 dan Gempa Padang Panjang 2007)
Authors: Putra Rusnardi Rahmat 
Published: January 2022

Tercatat 34 gempa dengan magnitude >4Mw yang terjadi di tahun 2020, meningkatnya jumlah dan intensitas kejadian gempa yang terjadi di Sumatera Barat menginformasikan bahwa aktifitas plat baik yang bersumber dari subduction maupun faultline yang berada di daratan Pulau Sumatera masih aktif. Salah satu gempa besar yang pernah terjadi di Sunatera Barat adalah gempa yang terjadi pada tanggal 30 September 2009 dengan kekuatan 7.6Mw, gempa ini memiliki percepatan yang tinggi yaitu 0.38m/s2. Penelitian ini mengunakan katalog dari United State Geological Survey (USGS) dalam menentukan foreshock dan aftershock. Penentuan foreshock dan aftershock tidak berdasarkan mekanisme kejadian gempanya tetapi berdasarkan waktu yaitu 0-3, 4-6, 7-9, 10-12 bulan, radius 0-50, 51-100, 101-150km, dan magnitude >4Mw. Hasil penelitian ini menunjukan jumlah foreshock dan aftershock untuk gempa Padang yang tejadi pada 30 September 2009 adalah 102 gempa untuk foreshock dan 49 gempa untuk aftershock dalam kurun waktu 1 tahun, sedangkan untuk gempa Padang Panjang yang terjadi pada tanggal 6 Maret 2007 dengan kekuatan 6.4Mw yaitu 2 kejadian untuk foreshock dan 15 kejadian untuk afreshock.
Evaluasi Fondasi Sumuran pada Proyek Pembangunan Gedung RSUD Kabupaten Padang Pariaman
Authors: Yulinar Urmila , Inra Azwar 
Published: January 2022

RSUD Padang Pariaman melengkapi fasilitas kesehatan untuk peningkatan kualitas pelayanan dengan membangun Gedung NICU, PICU dan HCU. Gedung RSUD Kabupaten Padang Pariaman menggunakan fondasi sumuran. Fondasi sumuran yang digunakan ada empat (4) tipe dengan diameter 1 meter dan kedalaman yang bervariasi. Jenis tanah pada lahan pembangunan ini ialah jenis tanah lempung, yang dari data boring diketahui bahwa lapisan tanah keras (NSPT≥ 40) tidak ditemukan sampai kedalaman -30 meter. Penelitian ini dilakukan untuk mengevaluasi daya dukung fondasi sumuran terhadap variasi kedalaman fondasi sumuran akibat beban vertikal dan horizontal bangunan Gedung RSUD Kabupaten Padang Pariaman. Hasil perhitungan daya dukung ijin dari 3 tipe fondasi sumuran menggunakan Metode Reese dan O’Neill (1989) dan Metode Meyerhof (1963) hanya satu fondasi yaitu tipe PC yang mampu menahan beban dari bangunan Gedung RSUD Kabupaten Padang Pariaman. Daya dukung ultimit ijin fondasi sumuran metode Reese dan O’Neill (1989) pada tipe P1 sebesar kN; , tipe P3 sebesar 170,11 kN; 257,29 kN, dan tipe PC sebesar 1227,96 kN; 1742,967 kN dan pada Metode Meyerhof didapatkan nilai daya dukung ijin fondasi sumuran tipe P1 sebesar 151,831kN, tipe P3 sebesar 72,29 kN, dan tipe PC sebesar 447,854 kN.
Endocrine disrupting chemicals and their detection in an IVF laboratory
Authors: Ješeta Michal , Franzová Kateřina , Mekiňová Lenka , Kistanova Elena , Harbulák Peter , Žáková Jana , Lousová Eva , Ventruba Pavel , Crha Igor 
Published: January 2022

Abstract
The endocrine disruptors are chemicals with the capacity to influence physiological processes in the organism, most often through hormonal control. They are present in the environment and in the products of daily use. They are often found in food, released from plastic bottles for water, present in cosmetics or fertilizers. Latest research suggests that they can be released from plastics used in the IVF laboratories and can be even present in the manipulation and cultivation media used for isolation and fertilization of gametes and subsequent cultivation of embryos. Permanent and long-term utilization of these substances has adverse effects in human reproductive health, mainly by the means of interfering with synthesis and action mechanisms of reproductive hormones. Moreover, some endocrine disruptors show a range of adverse effects directly on the gametes or embryos cultured in the in vitro conditions. The article provides an overview on bisphenols detected in plastics and media commonly used in the IVF laboratory and considers their possible impact on effectiveness of the IVF methods in a human laboratory.
New gene markers involved in regulation of granulosa cells development and differentiation towards endodermal and epithelial tissues – a new insight into the stemness specificity of ovarian follicular cells
Authors: Kranc Wiesława , Popis Małgorzata , Dompe Claudia , Golkar-Narenji Afsaneh , Jeseta Michal , Mozdziak Paul E , Kistanova Elena , Makarevich Alexander , Machatkova Marie , Bukowska Dorota , Prochazka Radek , Jaśkowski Jędrzej M. , Ratajczak Kornel , Sobolewski Jarosław , Antosik Paweł 
Published: January 2022

Abstract
Maintaining of female fertility is strictly dependent on proper hormonal regulation. Granulosa cells (GCs) are components of ovarian follicles, and they are important in paracrine regulation of the ovary. Preovulatory follicle GCs are responsible for production of estrogens to the ovary microenvironment and lead to the LH surge. Proper functioning of GCs is necessary to ensure appropriate conditions for oocyte development, maturation, ovulation and its release to the oviduct. Long-term in vitro culture of GCs show significant stem-like characteristics. Understanding the molecular processes underlying GCs differentiation towards different cell lineages may reveal other possible stem cell markers. A transcriptomic analysis of short-term primary in vitro cultured GCs, which were isolated from porcine preovulatory follicles was the major focus of the study. The ontological groups herby considered are associated with endodermal and epithelial tissues. Results were and compare to freshly isolated GC cells. 6 the most reduced expression: HSD17B1, DAPL1, NEBL, MAL2, DAB1, ITM2A were chosen for analysis. These genes have been response for processes associated with GCs development and differentiation towards endodermal and epithelial tissues, which make them important for further consideration.
Barriers Everyone: A New Method for Multiscale Analysis of Barriers Using the Barrier Index
Authors: Kušar Domen , Komac Blaž 
Published: January 2022

Abstract
The Barrier Index is presented in this contribution. The index shows the extent to which spatial units of different sizes are closed off by barriers, influencing society by the different “thickness” and “thinness” of boundaries. The article defines the Index and compares land units with barriers in various details. The calculations were made for spatial units from the scale of parcels to one-hectare areas in selected types of regions, selected geographic regions, and border barriers in selected countries. The Index is useful for crossscale analysis and for identifying the underlying causes and relationships within different cultural, social, and geographical contexts. The example of spatially persistent family structures was used to highlight the underpinning influencing factors that connect the building of barriers at different scales.
Towards Efficient Use of Cement in Ultra High Performance Concrete
Authors: Lande Ingrid , Thorstensen Rein Terje 
Published: January 2022

Abstract
This paper presents an investigation on substituting the cement content with an inert material, in a typical locally produced UHPC mix. A structured literature review was performed to enrichen the discussion and to benchmark the results towards already reported investigations in the research society. Investigations on cement substitution in UHPC are frequently reported. However, usually the cement is substituted with other binding materials – often pozzolanic by-products from other industries. Reports from investigations on the use of inert materials for cement substitution in UHPC seem scarce.
An experimental program that included a total of 210 test specimens was executed. This program included evaluating several questions embedded to the problem on how to substitute cement while keeping all other variables constant.
It is concluded that up to 40% of the cement can be substituted with an inert material, without significantly changing the flexural tensile strength or compressive strength of the hardened UHPC. Two preconditions were caretaken: the particle packing was maintained by securing that the substitution material had a Particle Size Distribution (PSD) near identical to the cement and that the water balance was maintained through preconditioning of the substitution material. Suggestions are made for improving benchmarking.
Evaluation of Rapid Repair of Concrete Pavements Using Precast Concrete Technology: A Sustainable and Cost-Effective Solution
Authors: Yaqoob Saima , Silfwerbrand Johan , Strömberg Larissa 
Published: January 2022

Abstract
Concrete and asphalt are the two competitive materials for a highway. In Sweden, the predominant material for the highway system is asphalt. But under certain conditions, concrete pavements are competitive alternatives. For example, concrete pavements are suitable for high-traffic volume roads, roads in tunnels, concentrated loads (e.g., bus stops and industrial pavement). Besides the load-carrying capacity, the concrete pavement has many advantages such as durability (wear resistance), resistance against frost heave, environment (pollution, recycling, and low rolling resistance leading to fuel savings), fire resistance, noise limitations, brightness, evenness and aesthetics.
Concrete pavements are long-lasting but need final repair. Single slabs may crack in the jointed concrete pavement due to various structural and non-structural factors. Repair and maintenance operations are, therefore, necessary to increase the service life of the structures. To avoid extended lane closures, prevent traffic congestions, and expedite the pavement construction process, precast concrete technology is a recent innovative construction method that can meet the requirement of rapid construction and rehabilitation of the pavement. This paper evaluates rapid repair techniques of concrete pavement using precast concrete technology by analysing three case studies on jointed precast concrete pavements. The study showed that the required amount of time to re-open the pavement to traffic is dramatically reduced with jointed precast concrete panels.
Numerical Modelling of Heat Transport in Freezing Mortars with an External Liquid Reservoir
Authors: Faheem Abdul , Ranger Maxime , Hasholt Marianne Tange 
Published: January 2022

Abstract
Several studies indicate that the temperature distribution in concrete may affect the extent of frost scaling. This study presents a numerical model that describes the thermal response of freezing mortars in the presence of an external liquid reservoir, where the external liquid is either pure water or 3% sodium chloride solution. The phase transformation of supercooled external liquid is modelled in two stages: quick freezing, when the supercooled liquid starts to form crystals and slow freezing. The model is developed in two parts. In part I, the focus is the modelling of external liquid, and therefore a non-porous body with an external liquid reservoir is modelled and validated. In part II, the model developed in part I is developed further for a porous body containing different phases, i.e., unfrozen liquid and ice, in the pores. A comparison of simulated and experimentally measured temperature distributions shows a good agreement.
Bilateral Trade By Products Between the V4 Countries and China in Years 2009–2019
Authors: Pangsy-Kania Sylwia 
Published: January 2022

Abstract

Subject and purpose: Using annual data for the periods 2009–2019, this paper examines trade flows between China and the Visegrad Group countries. The aim of this article is to assess real changes taking place in international trade in the Visegrad Group countries (V4) over the last eleven years. The starting point for the analysis was 2009 – the time after the 2008 economic crisis, and it was compared especially to 2018 – a year marked by a significant improvement in the economy. The purpose is to discuss concerns related to the differences in bilateral trade between China and Poland, Czech Republic, Hungary, and Slovak Republic. The main aim of this research is to distinguish the characteristics of bilateral trade by products between V4 and China in years 2009–2019. The purpose of this article is also to systematize and discuss points of view, rationalizing further empirical research. Two research hypotheses, resulting from the research purpose, were formulated: H1: in the V4 countries import exceeds export, and this trend seems to be growing, H2: Chinese goods imported to the V4 are much more sophisticated than those exported.

Design/Methodology/Approach: To assess the initial and current situation on international trade between the V4 and China, the author uses variables obtained from WTO and OEC resources, diagnosing the situation in Poland, Czech Republic, Hungary, and Slovak Republic. The collected empirical data were processed using theoretical methods such as analysis, synthesis, and comparison to formulate conclusions using deductive and inductive inference methods.

Practical Implications: The results can be used in scientific and expert work on diagnostic and forecast trends in bilateral trade by products between the V4 and China.

Originality/Value: It concerns the indication of the importance of the V4 trade with China compared to the share of the V4 countries in world trade. It was also possible to identify the top export and import products of the V4. The findings also confirm the significant change in China’s trading structure.