bluuebunny/crossref_metadata_2025_split huggingface dataset:
Streptomyces coeruleorubidus as a potential biocontrol agent for Newcastle disease virus
Authors: Abdelaziz Rewan , Tartor Yasmine H. , Barakat Ahmed B. , EL-Didamony Gamal , El-Samadony Hanaa A. , Amer Shimaa A. , Gado Marwa M. 
Published: June 2022

Abstract
Background
Newcastle disease virus (NDV) is a severe disease that affects domestic and wild birds. Controlled antibiotics derived from probiotics have been examined as prospective solutions for preserving seroconversion in NDV-vaccinated fowl. In this study, the secondary metabolite “telomycin” was extracted from Streptomyces coeruleorubidus (S. coeruleorubidus) isolated from Egypt's cultivated soil. The structure of telomycin was determined by the elucidation of spectroscopic analysis, including nuclear magnetic resonance (NMR) and mass spectrometry (MS) spectra, and comparison with the literature. The antiviral activity of the secondary metabolite was tested by checking its effect on NDV hemagglutination activity (HA). Moreover, HA of NDV was tested after inoculation of NDV (control) and a combination of telomycin and NDV in 10- days- specific pathogen-free embryonated chicken eggs (SPF-ECE) daily candling. Histopathological examination was performed for chorioallantoic membranes and liver of SPF-ECE.

Results
S. coeruleorubidus secondary metabolite “telomycin” showed complete hemagglutination inhibition (HI) activity of NDV strain (MN635617) with log106 infectivity titers (EID50/mL). The HA of NDV strain was 8 log2 and 9 log2 with 0.5% and 0.75% of chicken RBCs, respectively. Preserved structures of chorioallantoic-membranes (CAM) with dilated capillary networks were observed in the treated group inoculated with telomycin and NDV. Histological changes in SPF-ECE liver were examined after inoculation in ova to further characterize the telomycin effect. Telomycin and NDV mixture inoculated group showed preserved cytoarchitecture of hepatocytes with the presence of perivascular foci of lymphocytes. The group that was inoculated with telomycin alone showed normal histology of hepatic acini, central veins, and portal triads.

Conclusion
S. coeruleorubidus telomycin is a promising bioactive agent that might be a biological weapon against a deadly chicken NDV that costs farmers a lot of money.
Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance
Authors: Zhang Ping , Amarasinghe Harindra E. , Whalley Justin P. , Tay Chwen , Fang Hai , Migliorini Gabriele , Brown Andrew C. , Allcock Alice , Scozzafava Giuseppe , Rath Phalguni , Davies Benjamin , Knight Julian C. 
Published: June 2022

Abstract
Background
Chromatin states and enhancers associate gene expression, cell identity and disease. Here, we systematically delineate the acute innate immune response to endotoxin in terms of human macrophage enhancer activity and contrast with endotoxin tolerance, profiling the coding and non-coding transcriptome, chromatin accessibility and epigenetic modifications.

Results
We describe the spectrum of enhancers under acute and tolerance conditions and the regulatory networks between these enhancers and biological processes including gene expression, splicing regulation, transcription factor binding and enhancer RNA signatures. We demonstrate that the vast majority of differentially regulated enhancers on acute stimulation are subject to tolerance and that expression quantitative trait loci, disease-risk variants and eRNAs are enriched in these regulatory regions and related to context-specific gene expression. We find enrichment for context-specific eQTL involving endotoxin response and specific infections and delineate specific differential regions informative for GWAS variants in inflammatory bowel disease and multiple sclerosis, together with a context-specific enhancer involving a bacterial infection eQTL for KLF4. We show enrichment in differential enhancers for tolerance involving transcription factors NFκB-p65, STATs and IRFs and prioritize putative causal genes directly linking genetic variants and disease risk enhancers. We further delineate similarities and differences in epigenetic landscape between stem cell-derived macrophages and primary cells and characterize the context-specific enhancer activities for key innate immune response genes KLF4, SLAMF1 and IL2RA.

Conclusions
Our study demonstrates the importance of context-specific macrophage enhancers in gene regulation and utility for interpreting disease associations, providing a roadmap to link genetic variants with molecular and cellular functions.
Emerging in the East: the Shanghai Biennale’s pathways to legitimation, 1996 to 2018
Authors: Zhu Chenchen , Braden LEA 
Published: June 2022

AbstractThis study examines the 22-year development of the Shanghai Biennale from a localized contemporary art exhibition to an internationally renowned art biennale. Through the lens of organizational legitimacy, this research examines how the Shanghai Biennale negotiated changing external pressures to establish within China and grow into the international art world. Using a mix-methods approach, we first create a unique database of participant nationality and then examine artist and curatorial statements, media reports, and interviews with organizers and curators of the Shanghai Biennale from 1996 to 2018. Our study delineates three periods of the Shanghai Biennale’s development: incipient (1996–1998), internationalization (2000–2010), and expanding period (2012–2018). Through these periods we examine the different pathways by which the Shanghai Biennale attained legitimacy first within the local and national Chinese context and then within the Biennale’s expansion into the international art scene. We find at the beginning stage of the Shanghai Biennale, establishing local legitimacy was the foremost concern. When the Shanghai Biennale started to diffuse into the global art world in 2000, focus shifted towards remaking the Shanghai Biennale to comply with international perceptions. That said, our research finds both local and international legitimacy requirements remained salient simultaneously, with the importance of maintaining a good relationship with the Chinese State as a critical basis for internationalization and development. In the most recent editions, more local and non-Western features are included in the Shanghai Biennale, signaling the Biennale’s efforts of distinguishing itself in the global biennale scene. This research contributes to organizational study by closely examining a cultural organization’s ability to negotiate legitimacy requirements in different contexts, but also empirically responds to recent calls for studies on the global development of non-Western biennales.
Intrathoracic gossypiboma presenting 47 years later as a purulent fistula: a case report
Authors: Rafieian Shahab , Vahedi Matin , Sarbazzadeh Javad , Amini Hesam , Ershadi Reza 
Published: June 2022

Abstract
Background
Intrathoracic gossypiboma is a consequence of retained sponge/swap, gauzoma, muslinoma, textiloma, or cottonoid in the thoracic cavity during surgery. The thoracic cavity is of the rarest place for gossypiboma as these entities most occur after abdominal surgery.

Case presentation
We report a case of intrathoracic gossypiboma that was missed for an extended period of time with no symptoms and was successfully treated with surgical intervention.

Conclusions
The rarity of gossypiboma necessitates a high index of suspicion for correct diagnosis. Gossypiboma is often difficult to diagnose, leading to misdiagnosis and unnecessary interventions. It is important to consider this entity as a diagnosis in any case with an unexplained or unusual presentation during the postoperative period.
Life-threatening obsessive–compulsive disorder precipitated by the COVID-19 pandemic in an adolescent
Authors: Jayakumar Ahrane , Sanchez-Cerezo Javier , Khayam Afshan , Spreeuwenberg Brigitte , Hodes Matthew 
Published: June 2022

SummaryThe COVID-19 pandemic starting in 2020 has had massive mental health consequences worldwide. It has caused generalised fear and anxiety about catching, spreading and suffering from the virus. This article describes a fictionalised patient's presentation of life-threatening obsessive–compulsive disorder (OCD) associated with fears of catching COVID-19. The fears resulted in refusal to eat and drink, with subsequent weight loss that required paediatric admission. The scenario portrays the association between COVID-19 and life-threatening OCD symptoms and goes on to illustrate the patient's good response to standard OCD treatments.
A AMPLA NOÇÃO DE LINGUAGEM DE CHARLES S. PEIRCE: COMPARTILHAMENTO DE HÁBITOS
Authors: Augusto Ferraz Alexandre 
Published: June 2022

Resumo: O método científico de investigação de Peirce, conjugado com seu antropomorfismo, o conduziu à elaboração de uma noção tão ampla de linguagem que estende em muito o universo estritamente humano relacionado à língua verbal. O antropomorfismo como método ajudou Peirce a elaborar uma semiótica que busca compreender a lógica que está subjacente à produção de significado nos mais distintos sistemas, compreendendo desde o reino humano, passando pelo reino biológico animal e vegetal, alcançando até mesmo o reino físico. Talvez o conceito peirceano que esteja na intersecção da compreensão desses diversos sistemas de significação seja o conceito de hábito, não só pelo fato de que a aquisição de hábitos pode ser verificada em todos os sistemas do universo, mas também pelo fato de que o hábito parece ser o elo desses sistemas entre si. Dessa maneira, a lei de aquisição de hábitos, segundo Peirce, é a efetiva lei do universo, formando uma grande estrutura complexa inteligível por meio de processos informacionais, o cosmos. O presente artigo busca explicitar como esse processo de aquisição de significado se dá, desde o universo humano, até o universo da física. Com isso, explicitamos como a noção de linguagem de Peirce (lógica-semiótica, relativa à produção de significado e de conhecimento) atingiu seus extremos.
PALAVRAS-CHAVE: Peirce; Linguagem; Hábito; Conhecimento; Significado.
ABSTRACT: Peirce’s scientific method of investigation associated with his anthropomorphism has conducted him to the elaboration of a broader notion of language which in turn extends the human universe related to verbal language. The anthropomorphism as method helped Peirce in the elaboration of a semiotic which seek for understanding the underlying logic in the production of meaning in several systems, since human and biological realms until reaching even the physical one. The concept of habit seems to be in the very intersection of the understanding of these systems, inasmuch as habit acquisition process can be verified in all of them, including the possible relationships between these domains of reality. According to Peirce, the law of habit acquisition is the law of the universe, constituting a large intelligible and complex structure by means of informational processes, the cosmos. This paper intends to make explicit this process of acquisition of meaning (habits), taking briefly into account human mind and behavior (process of inquiry), animal communication (E. coli bacteria) and physical processes (atomic structure). Thus, we make explicit how Peirce’s notion of language (logical-semiotic, related to meaning and knowledge) has reached a large extend.
KEYWORDS: Peirce; Language; Habit; Knowledge; Meaning.
NARRATOLOGIA COGNITIVA: UMA INTRODUÇÃO
Authors: Dolabela Chagas Pedro Ramos , De Andrade Moreira Anny Clarissa , Ferreira Almada Leonardo 
Published: June 2022

RESUMO: Este artigo apresenta ao leitor brasileiro a narratologia cognitiva, de recente desenvolvimento nos estudos literários. Discute-se sua articulação à filosofia da mente, à teoria da evolução cultural humana, à neurociência e à psicologia cognitiva, com seus desdobramentos para a compreensão da narrativa e da ficção como práticas culturais humanas, e dos seus efeitos sobre a mente do leitor. Para tanto, são resgatados os movimentos fundadores do novo paradigma e as proposições de alguns dos seus autores centrais.
PALAVRAS-CHAVE: Narratologia, Cognição, Evolução cultural humana, teoria da ficção.
ABSTRACT: This article introduces the Brazilian reader to the field of cognitive narratology, recently developed in the literary studies. It discusses its articulation with philosophy of mind, the theory of human cultural evolution, neuroscience and cognitive psychology, with its consequences for our understanding of narrative and fiction as human cultural practices, and of their effects on the reader’s mind. We therefore present the founding movements of the new paradigm, together with propositions from some of its leading authors.
KEYWORDS: Narratology, Cognition, Human cultural evolution, Theory of fiction.
The influence of blood donation before pregnancy on neonatal birth weight
Authors: Lu Genjie , Zhu Zhe , Lu Yangfang , Shen Jun , Yu Qilin , Gao Li , Chen Wei 
Published: June 2022

Objective
To evaluate the effect of blood donation before pregnancy on neonatal birth weight.

Methods
A total of 14996 women with singleton pregnancies at full-term in Ningbo Medical Center Lihuili Hospital and Ningbo Women’s and Children’s Hospital from November 2019 to November 2020 were enrolled in this study. Detailed records of whole blood donation before pregnancy were obtained through Alipay software. The records were classified into three groups: nondonors, low-frequency donors and high-frequency donors according to the total numbers of blood donations in the 3-year period before pregnancy. The demographics and clinical information of the enrolled participants and their fetuses were collected from electronic medical records (EMRs). The effect of blood donations in the 3-year period before pregnancy on neonatal birth weight was analyzed.

Results
There was no significant difference in neonatal birth weight among the three groups (P = 0.373). In line with this, there was no association between the number of blood donations in the 3-year period before pregnancy and neonatal birth weight (β = 14.5; 95% confidence interval [CI]: -3.9, 31.4; P = 0.094) in the bootstrapped multivariate linear regression analysis models, adjusted for maternal age, number of pregnancies, number of deliveries, gestational age, mode of delivery, years of education and blood type in pregnant women. Compared to the nondonors, the risk of fetal macrosomia was higher in both low-frequency donors and all donors (OR: 1.539, 95% CI: 1.058, 2.134, P = 0.016; OR: 1.454, 95% CI: 1.033, 1.952, P = 0.021, respectively), in the bootstrapped binary logistic regression analysis models after adjusting for the variables mentioned above.

Conclusion
Our study showed that maternal blood donation in the 3-year period before pregnancy may not lead to a reduction in neonatal birth weight, but may be associated with the incidence of fetal macrosomia.
Bicarbonate concentration as a predictor of prognosis in moderately severe COVID-19 patients: A multicenter retrospective study
Authors: Sada Ken-ei , Yamamoto Ryohei , Yano Akihiko , Miyauchi Atsushi , Kawamura Masafumi , Ito Hideki 
Published: June 2022

BackgroundCoronavirus disease 2019 (COVID-19) patients reportedly have high bicarbonate concentration. However, its relationship to the disease progression are obscure.MethodsIn this two-center retrospective study, we included COVID-19 patients with moderate severity between March 2020 and May 2021. We classified patients into three groups according to bicarbonate concentrations: high (>27 mEq/L), normal (21 to 27 mEq/L), and low (<21 mEq/L). The primary outcome was the time to clinical worsening defined by the requirement of intubation or death during 90 days. We evaluated high or low bicarbonate concentration during the clinical course related to the primary outcome using multivariable Cox proportional hazard models.ResultsOf the 60 participants (median age 72 years), 60% were men. Participants were classified into high (13 patients), normal (30 patients), and low (17 patients) groups. Clinical worsening occurred in 54% of patients in the high group, 23% in the normal group, and 65% in the low group. Both high and low groups were associated with a higher clinical worsening rate: HR, 3.02 (95% CI, 1.05 to 8.63) in the high group; 3.49 (95% CI: 1.33 to 9.12) in the low group.ConclusionMonitoring of bicarbonate concentrations may be useful to predict the prognosis.
Survival effects of primary and metastatic surgical treatment in metastatic small intestinal tumors: A propensity score–matching study
Authors: Zhou Zhongyi , Ge Heming , Li Yuqiang , Wang Dan , Güngör Cenap 
Published: June 2022

Objective
To analyze the effects of primary tumor resection and metastatic lesion resection on the survival of metastatic small intestinal tumors.

Methods
The research subjects were patients with metastatic small bowel tumors identified from 2004 to 2016 in the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching and Kaplan–Meier analyses were performed to analyze the effect of surgery on the prognosis.

Results
A total of 4,034 patients from the SEER database were analyzed. Both before and after the propensity score–matching analysis, the prognosis of patients who underwent primary tumor surgery and metastatic surgery was better than that of patients who did not undergo surgery; all were patients with metastatic small bowel adenocarcinoma (mSIA) or metastatic small intestinal neuroendocrine tumors (mSI-NETs) (all p < .005). Patients with mSIA and adequate lymph node dissection had a longer prognosis than mSIA patients with inadequate lymph node dissection, but this survival benefit was not present in mSI-NET patients. It made no difference in the prognosis of mSIA and mSI-NETs whether localized surgery or intestine-ectomy was performed. Patients with mSIA who underwent primary and metastatic excision plus chemotherapy had the best overall survival and cancer-specific survival rates, whereas mSI-NET patients who underwent primary and metastatic excision had the best overall survival and cancer-specific survival rates (all p < .001).

Conclusion
In these carefully selected patients, primary tumor resection and/or metastatic lesion resection significantly improved the survival rates for patients with mSIA and mSI-NETs. The mSIA patients with resectable primary tumors seemed to require a sufficient number of lymph node dissections more than the patients with well-differentiated mSI-NETs.
Hepatic Necrosis Mimicking Infiltrative Masses in Acute Budd-Chiari Syndrome With Hereditary Protein C Deficiency
Authors: Ananchuensook Prooksa , Karuehardsuwan Julalak , Sanpawat Anapat , Wisedopas Naruemon , Treeprasertsuk Sombat , Komolmit Piyawat , Thanapirom Kessarin 
Published: June 2022

ABSTRACT
We report the case of a patient with an unusual acute Budd-Chiari syndrome (BCS). The patient presented with high-grade fever and right upper quadrant pain. Infiltrative lesions at the right hepatic lobe and segment IVB with intrahepatic inferior vena cava and right hepatic vein thrombus appeared on abdominal imaging. Liver biopsy revealed hepatic infarction compatible with acute BCS. Thrombophilia work-up demonstrated low protein C activity with the -1657C/T mutation of the PROC gene. Necrotic liver mass with acute BCS related to congenital protein C deficiency was diagnosed. Patient symptoms and necrotic masses improved after anticoagulant treatment for 4 months.
Childbearing and Delivery in Women With Ulcerative Colitis and Ileostomy or Ileal Pouch-Anal Anastomosis
Authors: Campigotto Michele , Braini Andrea , Casarotto Maria Maddalena , Crocè Saveria Lory , Sablich Renato 
Published: June 2022

ABSTRACT
No detailed information is currently available about the management of pregnancy and delivery in patients with a stoma after colectomy for ulcerative colitis. We describe the case of a young pregnant woman with terminal ileostomy after toxic megacolon. Episodes of stoma occlusion, determined by the enlargement of the uterus, were treated with endoscopic decompression and daily assumption of oral laxatives, making possible to avoid surgery and carry pregnancy on until caesarean section was performed at week 37. Fertility issues, facing pregnancy with ileostomy rather than with ileal pouch-anal anastomosis, and choice of caesarean section rather than vaginal delivery are discussed.
Pedagogical Interrelationships
Authors: Chadha Anita 
Published: June 2022

Research indicates that peer interaction in the online classroom engages students in academic reflective deliberations. This study assesses student peer interactions on a purposefully designed collaborative website in an American politics course offered across two courses. Significant evidence reveals that students are open, candid, and inquisitive of varied positions while interacting with academic reflectivity across each question asked of them. They argue their perspectives with each other, teach and add information to their deliberations while being academically reflective. This study concludes that a peer interactive design is an invaluable method to engage students in academic deliberation while providing educators, researchers, and administrators an innovative means to enhance active learning and participation online.
Presepsin levels in neonatal cord blood are not influenced by maternal SARS-CoV-2 infection
Authors: Priolo Francesca , Fattore Simona , Tedesco Marta , De Rose Domenico Umberto , Chioma Roberto , Perri Alessandro , Costa Simonetta , Rubortone Serena Antonia , Patti Maria Letizia , Sbordone Annamaria , Maggio Luca , Vento Giovanni 
Published: June 2022

Abstract

Objectives
Coronavirus disease (COVID-19) can present with various symptoms and can involve multiple organs. Women infected during pregnancy have a higher incidence of obstetrical complications and infants born to “positive” mothers may get the infection with different manifestations. Presepsin seems to be a promising sepsis biomarker in adults and neonates. The aim of this study was to assess if presepsin levels in neonatal cord blood could be influenced by maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Methods
A total of 119 neonates born from women with a confirmed diagnosis of SARS-CoV-2 infection were enrolled and presepsin levels of cord blood samples were collected. All neonates were tested for SARS-CoV-2 infection at birth and after 48–72 h.

Results
The median presepsin value in umbilical cord blood samples collected after birth was 455 pg/mL. Presepsin levels were not influenced by maternal symptoms of COVID-19, weight for gestational age, or delivery mode, and did not significantly differ between infants with and without adverse neonatal outcomes. Infants hospitalized for more than 5 days had a significantly higher presepsin level at birth rather than those discharged up to 4 days of life. Three infants with positive nasopharyngeal swab at birth had higher Presepsin levels than two infants tested positive at 48 h.

Conclusions
This is the first study reporting cord presepsin levels in term and preterm infants born to mothers with COVID-19, that appeared to be not influenced by maternal clinical presentation. However, further studies are needed to explain the mechanisms of P-SEP increase in neonates exposed to perinatal maternal SARS-CoV-2 infection or with an indeterminate/possible SARS-CoV-2 infection in the same neonates.
On the degree of algebraic cycles on hypersurfaces
Authors: Paulsen Matthias 
Published: June 2022

Abstract
Let

X
⊂

ℙ
4

{X\subset\mathbb{P}^{4}}

be a very general hypersurface of degree

d
≥
6

{d\geq 6}

.
Griffiths and Harris conjectured in 1985 that the degree of every curve

C
⊂
X

{C\subset X}

is divisible by d.
Despite substantial progress by Kollár in 1991, this conjecture is not known for a single value of d.
Building on Kollár’s method, we prove this conjecture for infinitely many d, the smallest one being

d
=
5005

{d=5005}

.
The set of these degrees d has positive density.
We also prove a higher-dimensional analogue of this result and construct smooth hypersurfaces defined over

ℚ

{\mathbb{Q}}

that satisfy the conjecture.