bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wie bleiben Pflegende gesund
Authors: Ledtermann Ivonne 
Published: February 2022

Was ist zu diesem Thema bereits bekannt? Die Salutogenese und die Resilienz haben jeweils eine positive Wirkung auf die Gesundheit Pflegender. Diese beiden Gesundheitsmodelle werden einzeln erforscht und in Einrichtungen einzeln angewendet. Was ist neu, wie wird eine neue Perspektive eingebracht? Um eine umfassendere Gesundheitsförderung zu erzielen, könnten die Salutogenese und die Resilienz miteinander verknüpft werden. Was sind die Auswirkungen für die Praxis? Es könnten gezieltere Maßnahmen und Konzepte entwickelt werden, um die Gesundheit psychiatrisch Pflegender zu erhalten und zu fördern.
In‐Depth Evaluation of MiRS Total Precipitable Water From NOAA‐20 ATMS Using Multiple Reference Data Sets
Authors: Lee Yong‐Keun , Grassotti Christopher , Liu Quanhua (Mark) , Liu Shu‐Yan , Zhou Yan 
Published: February 2022

AbstractThe National Oceanic and Atmospheric Administration (NOAA) Microwave Integrated Retrieval System (MiRS) algorithm has been producing retrieval products from NOAA‐20 Advanced Technology Microwave Sounder (ATMS) data since shortly after launch in late 2017. Retrieval products from the Suomi National Polar‐orbiting Partnership (SNPP) ATMS data have been similarly available since 2012. Among the products routinely generated is Total Precipitable Water (TPW), based on the vertical integral of the MiRS retrieved water vapor profile. In this study, TPW data from NOAA‐20 ATMS have been the subject of an in‐depth evaluation. The evaluation included characterization of dependence on orbital node (ascending/descending), season, surface type, scan angle, and meridional (zonally averaged) variation. Due to the similarity between NOAA‐20 and SNPP derived TPW, the emphasis here is on the NOAA‐20 evaluation. The globally averaged values of TPW for 2019 are 25.41 and 25.39 mm from NOAA‐20 and SNPP ATMS, respectively, for combined orbits (ascending and descending). For combined orbits, the bias and standard deviation of MiRS NOAA‐20 ATMS TPW with respect to European Centre for Medium‐Range Weather Forecasts/Global Data Assimilation System (ECMWF/GDAS) analyses are 0.79/1.76 mm and 3.65/3.55 mm, respectively, at 10°N where part of annual mean Intertropical Convergence Zone (ITCZ) is located, while at 40°N, corresponding bias and standard deviation values are 0.84/0.67 mm and 3.00/2.55 mm, respectively. The yearly averaged horizontal distribution of MiRS TPW retrieved from NOAA‐20 ATMS is highly correlated with that of ECMWF and GDAS analyses data, with a correlation coefficient of ∼1.
Three‐Dimensional Surface Downwelling Longwave Radiation Clear‐Sky Effects in the Upper Colorado River Basin
Authors: Feldman D. R. , Worden M. , Falco N. , Dennedy‐Frank P. J. , Chen J. , Dafflon B. , Wainwright H. 
Published: February 2022

AbstractIn complex terrain, non‐parallel surfaces receive emitted radiation from adjacent surfaces. Qualitatively, where surface skin temperatures and lower tropospheric temperature and humidity are not uniform, the downwelling longwave radiation (DLR) will be determined not just by radiation from the atmosphere above a given location, but also by adjacent surface temperatures. We quantify this three‐dimensional longwave radiative effect over the Upper Colorado River Basin in clear‐sky conditions by calculating surface DLR with observed land‐surface temperatures from ECOSTRESS. We find that this effect is due to terrain‐subtended sky‐view and represents ∼22% of the surface longwave flux, rising to ∼28% and ∼24% in the East and Southeast of the Basin, respectively, and can be >50% in extreme cases. The common omission of this effect in atmospheric radiation models leads to an underestimation of DLR in complex terrain, especially at higher elevations, which has significant implications for mountainous ecohydrology simulations.
Do More Frequent Temperature Inversions Aggravate Haze Pollution in China?
Authors: Bai Kaixu , Li Ke , Guo Jianping , Cheng Wei , Xu Xiaofeng 
Published: February 2022

AbstractBy using twice daily high‐resolution radiosonde observations, here we assessed spatiotemporal variability of temperature inversion (TI) and its impact on PM2.5 pollution levels in China from 2014 to 2020. It was found that both surface‐based inversion (SBI) and elevated inversion (EI) became increasingly frequent across China, at a rate of 1.42% a−1 (1.15% a−1) and 2.82% a−1 (3.23% a−1) at 0800 (2000) Beijing time (BJT), respectively. However, the intensity of SBI and EI at 0800 (2000) BJT decreased at −0.17 (−0.43) and −0.07 (−0.05) °C 100m−1 decade−1, making annual mean PM2.5 increment induced by TI dip by 52.5% (73.2%) for the whole study period. Still positive TI induced PM2.5 increments demonstrate an offsetting effect between TI and emission control on haze pollution, underscoring the importance of fully considering TI contribution when assessing the emission control effect on haze reduction.
Potential Link Between Ice Nucleation and Climate Model Spread in Arctic Amplification
Authors: Tan Ivy , Barahona Donifan , Coopman Quentin 
Published: February 2022

AbstractArctic amplification (AA) is simulated by all global climate models, however the spread in the degree of projected warming is large and the underlying mechanisms driving it are poorly understood. The impact of the temperature dependence of immersion freezing on cloud feedbacks and AA is studied using NASA's GEOS‐5 model. Parameterizations that exhibit low ice‐nucleating particle (INP) concentrations in the high Arctic during summer are found to weaken the cloud‐phase feedback. This allows sunlight to readily melt sea‐ice in the summer, which decreases the stability of the lower troposphere, causing a decrease in wintertime cloud fraction over open ocean. Arctic amplification was found to span from ∼1.4 to >2.6, which spans 30% of the spread in AA in the coupled model intercomparison project models, depending on the temperature dependence of immersion freezing. These results suggest that summertime INP concentrations may provide an observational constraint on AA.
Evolution of Short‐Term Seismic Hazard in Alberta, Canada, From Induced and Natural Earthquakes: 2011–2020
Authors: Reyes Canales Mauricio , Yusifbayov Javad , van der Baan Mirko 
Published: February 2022

AbstractWe generate short‐term seismic hazard maps for the province of Alberta, Canada, from 2011 through 2020. First, we describe the required adaptations to probabilistic seismic hazard analysis to generate short‐term seismic hazard maps, following the Monte Carlo simulation approach. Second, we identify the natural and induced seismic source areas in Alberta and estimate their earthquake recurrence parameters revealing considerable spatio‐temporal variations in the ‐ and ‐values in the different seismic clusters in the province. Areas with the highest short‐term seismic hazard during the last decade in Alberta are related to cases of induced seismicity, including hydraulic fracturing activities in the Duvernay Fm., near Fox Creek, and waste‐water disposal activities near the Musreau Lake. These maps provide a valuable tool to quantify the short‐term evolution in the seismic hazard, which is particularly important considering past and emerging cases of induced seismicity related to the energy sector in Alberta. Furthermore, using parameters from the previous year, we make a seismic hazard forecast for the year 2021. Our analysis provides a baseline of expected short‐term seismic hazard, with inheren uncertainty due to the assumption of unchanged recurrence parameters from the previous year; yet our study reveals pertinent seismicity patterns in line with changing human activities.
A Coupled Dynamic System Inversion Model for Higher Accuracy in Flood Forecasting
Authors: Huang Yixin , Liang Zhongmin , Singh Vijay P. , Hu Yiming , Li Binquan , Wang Jun 
Published: February 2022

AbstractFlood routing is a critical component of real‐time flood forecasting and plays a pivotal role in reducing economic and life losses due to flooding. However, flood routing always possesses errors because it is affected by various sources of uncertainty, which are transmitted and accumulated in the routing process from upstream to downstream, particularly for long or complex river systems. Thus, a real‐time error correction is rapidly becoming a key measure for reducing errors and improving flood forecasting accuracy. In this study, a dynamic system inversion (DSI) model was developed as a new correction method to update forecasting errors for long river systems. The new method utilizes all observed, forecasted, and corrected information at upstream stations and couples the matrix‐based Muskingum routing method with an error‐inversed updating technique to form the DSI equation. Multisource spatiotemporal errors of the river system are simultaneously combined into the DSI equation, and the discharges at the downstream station are reforecasted, thereby providing error correction in flood routing. Based on a case study on the Le'an River (China), the DSI model performed better than the traditional autoregressive (AR) model based on five metrics for both small and large flood events. Moreover, with an increase in lead time, the metrics of AR deteriorated rapidly, whereas that of DSI deteriorated slightly. In conclusion, the proposed DSI model is a sophisticated and robust method for flood routing and provides a new alternative for error correction in flood routing simulations of complex river systems.
Genetic variants in eleven central and peripheral chemoreceptor genes in sudden infant death syndrome
Authors: Neubauer Jacqueline , Forst Anna-Lena , Warth Richard , Both Christian Peter , Haas Cordula , Thomas Jörg 
Published: February 2022

Abstract
Background
Sudden infant death syndrome (SIDS) is still one of the leading causes of postnatal infant death in developed countries. The occurrence of SIDS is described by a multifactorial etiology that involves the respiratory control system including chemoreception. It is still unclear whether genetic variants in genes involved in respiratory chemoreception might play a role in SIDS.

Methods
The exome data of 155 SIDS cases were screened for variants within 11 genes described in chemoreception. Pathogenicity of variants was assigned based on the assessment of variant types and in silico protein predictions according to the current recommendations of the American College of Medical Genetics and Genomics.

Results
Potential pathogenic variants in genes encoding proteins involved in respiratory chemoreception could be identified in 5 (3%) SIDS cases. Two of the variants (R137S/A188S) were found in the KNCJ16 gene, which encodes for the potassium channel Kir5.1, presumably involved in central chemoreception. Electrophysiologic analysis of these KCNJ16 variants revealed a loss-of-function for the R137S variant but no obvious impairment for the A188S variant.

Conclusions
Genetic variants in genes involved in respiratory chemoreception may be a risk factor in a fraction of SIDS cases and may thereby contribute to the multifactorial etiology of SIDS.

Impact

What is the key message of your article?

Gene variants encoding proteins involved in respiratory chemoreception may play a role in a minority of SIDS cases.

What does it add to the existing literature?

Although impaired respiratory chemoreception has been suggested as an important risk factor for SIDS, genetic variants in single genes seem to play a minor role.

What is the impact?

This study supports previous findings, which indicate that genetic variants in single genes involved in respiratory control do not have a dominant role in SIDS.
Comprehensive metabolomics expands precision medicine for triple-negative breast cancer
Authors: Xiao Yi , Ma Ding , Yang Yun-Song , Yang Fan , Ding Jia-Han , Gong Yue , Jiang Lin , Ge Li-Ping , Wu Song-Yang , Yu Qiang , Zhang Qing , Bertucci François , Sun Qiuzhuang , Hu Xin , Li Da-Qiang , Shao Zhi-Ming , Jiang Yi-Zhou 
Published: February 2022

AbstractMetabolic reprogramming is a hallmark of cancer. However, systematic characterizations of metabolites in triple-negative breast cancer (TNBC) are still lacking. Our study profiled the polar metabolome and lipidome in 330 TNBC samples and 149 paired normal breast tissues to construct a large metabolomic atlas of TNBC. Combining with previously established transcriptomic and genomic data of the same cohort, we conducted a comprehensive analysis linking TNBC metabolome to genomics. Our study classified TNBCs into three distinct metabolomic subgroups: C1, characterized by the enrichment of ceramides and fatty acids; C2, featured with the upregulation of metabolites related to oxidation reaction and glycosyl transfer; and C3, having the lowest level of metabolic dysregulation. Based on this newly developed metabolomic dataset, we refined previous TNBC transcriptomic subtypes and identified some crucial subtype-specific metabolites as potential therapeutic targets. The transcriptomic luminal androgen receptor (LAR) subtype overlapped with metabolomic C1 subtype. Experiments on patient-derived organoid and xenograft models indicate that targeting sphingosine-1-phosphate (S1P), an intermediate of the ceramide pathway, is a promising therapy for LAR tumors. Moreover, the transcriptomic basal-like immune-suppressed (BLIS) subtype contained two prognostic metabolomic subgroups (C2 and C3), which could be distinguished through machine-learning methods. We show that N-acetyl-aspartyl-glutamate is a crucial tumor-promoting metabolite and potential therapeutic target for high-risk BLIS tumors. Together, our study reveals the clinical significance of TNBC metabolomics, which can not only optimize the transcriptomic subtyping system, but also suggest novel therapeutic targets. This metabolomic dataset can serve as a useful public resource to promote precision treatment of TNBC.
Systemic adjuvant chemotherapy for advanced malignant ocular medulloepithelioma
Authors: Sheriff Ibrahim H. N. , Karaa Esin K. , Chowdhury Tanzina , Scheimberg Irene , Duncan Catriona , Reddy M. Ashwin , Sagoo Mandeep S. 
Published: February 2022

Abstract
Background
Ocular medulloepithelioma (diktyoma) is a rare and potentially malignant paediatric tumour of the non-pigmented ciliary epithelium. Adjuvant chemotherapy can be given in advanced cases, but the indications and regimens remain to be defined. The aim was to identify whether adjuvant chemotherapy offers treatment benefit in advanced ocular medulloepithelioma.

Methods
This was a retrospective case series of subjects referred to a single specialist ocular oncology centre for advanced ocular medulloepithelioma subsequently treated with enucleation, including those needing adjuvant systemic vincristine, etoposide and carboplatin. A case-note review was performed for included subjects meeting referral criteria. The outcomes were histopathology characteristics, recurrence, metastases and survival.

Results
Between March 2010 and June 2017, four male patients (mean age 31 months) underwent enucleation for ocular medulloepithelioma. Adjuvant chemotherapy was commenced in 3 patients (75%) due to malignant histopathological features. With a mean follow-up time of 81.5 months (median 71 months, range 49–135 months) none of the patients have had recurrence, metastases or death from the tumour.

Conclusions
This series is unique in reporting the management of advanced malignant ocular medulloepithelioma with adjuvant systemic vincristine, etoposide and carboplatin for advanced tumours with malignant features. This regimen appears to be safe and may be effective in preventing metastatic spread.
Large planets may not form fractionally large moons
Authors: Nakajima Miki , Genda Hidenori , Asphaug Erik , Ida Shigeru 
Published: February 2022

AbstractOne of the unique aspects of Earth is that it has a fractionally large Moon, which is thought to have formed from a Moon-forming disk generated by a giant impact. The Moon stabilizes the Earth’s spin axis at least by several degrees and contributes to Earth’s stable climate. Given that impacts are common during planet formation, exomoons, which are moons around planets in extrasolar systems, should be common as well, but no exomoon has been confirmed. Here we propose that an initially vapor-rich moon-forming disk is not capable of forming a moon that is large with respect to the size of the planet because growing moonlets, which are building blocks of a moon, experience strong gas drag and quickly fall toward the planet. Our impact simulations show that terrestrial and icy planets that are larger than ~1.3−1.6R⊕ produce entirely vapor disks, which fail to form a fractionally large moon. This indicates that (1) our model supports the Moon-formation models that produce vapor-poor disks and (2) rocky and icy exoplanets whose radii are smaller than ~1.6R⊕ are ideal candidates for hosting fractionally large exomoons.
Automatic mapping of multiplexed social receptive fields by deep learning and GPU-accelerated 3D videography
Authors: Ebbesen Christian L. , Froemke Robert C. 
Published: February 2022

AbstractSocial interactions powerfully impact the brain and the body, but high-resolution descriptions of these important physical interactions and their neural correlates are lacking. Currently, most studies rely on labor-intensive methods such as manual annotation. Scalable and objective tracking methods are required to understand the neural circuits underlying social behavior. Here we describe a hardware/software system and analysis pipeline that combines 3D videography, deep learning, physical modeling, and GPU-accelerated robust optimization, with automatic analysis of neuronal receptive fields recorded in interacting mice. Our system (“3DDD Social Mouse Tracker”) is capable of fully automatic multi-animal tracking with minimal errors (including in complete darkness) during complex, spontaneous social encounters, together with simultaneous electrophysiological recordings. We capture posture dynamics of multiple unmarked mice with high spatiotemporal precision (~2 mm, 60 frames/s). A statistical model that relates 3D behavior and neural activity reveals multiplexed ‘social receptive fields’ of neurons in barrel cortex. Our approach could be broadly useful for neurobehavioral studies of multiple animals interacting in complex low-light environments.
Room-temperature optically detected magnetic resonance of single defects in hexagonal boron nitride
Authors: Stern Hannah L. , Gu Qiushi , Jarman John , Eizagirre Barker Simone , Mendelson Noah , Chugh Dipankar , Schott Sam , Tan Hoe H. , Sirringhaus Henning , Aharonovich Igor , Atatüre Mete 
Published: February 2022

AbstractOptically addressable solid-state spins are important platforms for quantum technologies, such as repeaters and sensors. Spins in two-dimensional materials offer an advantage, as the reduced dimensionality enables feasible on-chip integration into devices. Here, we report room-temperature optically detected magnetic resonance (ODMR) from single carbon-related defects in hexagonal boron nitride with up to 100 times stronger contrast than the ensemble average. We identify two distinct bunching timescales in the second-order intensity-correlation measurements for ODMR-active defects, but only one for those without an ODMR response. We also observe either positive or negative ODMR signal for each defect. Based on kinematic models, we relate this bipolarity to highly tuneable internal optical rates. Finally, we resolve an ODMR fine structure in the form of an angle-dependent doublet resonance, indicative of weak but finite zero-field splitting. Our results offer a promising route towards realising a room-temperature spin-photon quantum interface in hexagonal boron nitride.
ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer
Authors: Napoli Marco , Wu Sarah J. , Gore Bethanie L. , Abbas Hussein A. , Lee Kyubum , Checker Rahul , Dhar Shilpa , Rajapakshe Kimal , Tan Aik Choon , Lee Min Gyu , Coarfa Cristian , Flores Elsa R. 
Published: February 2022

AbstractDistinct lung stem cells give rise to lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC). ΔNp63, the p53 family member and p63 isoform, guides the maturation of these stem cells through the regulation of their self-renewal and terminal differentiation; however, the underlying mechanistic role regulated by ∆Np63 in lung cancer development has remained elusive. By utilizing a ΔNp63-specific conditional knockout mouse model and xenograft models of LUAD and LUSC, we found that ∆Np63 promotes non-small cell lung cancer by maintaining the lung stem cells necessary for lung cancer cell initiation and progression in quiescence. ChIP-seq analysis of lung basal cells, alveolar type 2 (AT2) cells, and LUAD reveals robust ∆Np63 regulation of a common landscape of enhancers of cell identity genes. Importantly, one of these genes, BCL9L, is among the enhancer associated genes regulated by ∆Np63 in Kras-driven LUAD and mediates the oncogenic effects of ∆Np63 in both LUAD and LUSC. Accordingly, high BCL9L levels correlate with poor prognosis in LUAD patients. Taken together, our findings provide a unifying oncogenic role for ∆Np63 in both LUAD and LUSC through the regulation of a common landscape of enhancer associated genes.
Relative effects of land conversion and land-use intensity on terrestrial vertebrate diversity
Authors: Semenchuk Philipp , Plutzar Christoph , Kastner Thomas , Matej Sarah , Bidoglio Giorgio , Erb Karl-Heinz , Essl Franz , Haberl Helmut , Wessely Johannes , Krausmann Fridolin , Dullinger Stefan 
Published: February 2022

AbstractLand-use has transformed ecosystems over three quarters of the terrestrial surface, with massive repercussions on biodiversity. Land-use intensity is known to contribute to the effects of land-use on biodiversity, but the magnitude of this contribution remains uncertain. Here, we use a modified countryside species-area model to compute a global account of the impending biodiversity loss caused by current land-use patterns, explicitly addressing the role of land-use intensity based on two sets of intensity indicators. We find that land-use entails the loss of ~15% of terrestrial vertebrate species from the average 5 × 5 arcmin-landscape outside remaining wilderness areas and ~14% of their average native area-of-habitat, with a risk of global extinction for 556 individual species. Given the large fraction of global land currently used under low land-use intensity, we find its contribution to biodiversity loss to be substantial (~25%). While both sets of intensity indicators yield similar global average results, we find regional differences between them and discuss data gaps. Our results support calls for improved sustainable intensification strategies and demand-side actions to reduce trade-offs between food security and biodiversity conservation.