bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclic behavior of late quaternary alluvial soil along Indo-Gangetic Plain: Northern India
Authors: Naik Sambit Prasanajit , Patra Nihar Ranjan , Malik Javed N. 
Published: January 2022

AbstractThe A.D. 1803 and 1934 Bihar-Nepal border earthquake affected Indo-Gangetic Plain with evidences of liquefaction in cities like Patna, Varanasi, Agra, and Delhi in historical past. Recent strong shaking all along the Indo-Gangetic Plains and seismic induced damage to the buildings in Bihar during Mw7.8 Gorkha earthquake raises the concern for site specific liquefaction potential estimation of alluvial soils. Cyclic triaxial tests were conducted on soil samples from Kanpur, Allahabad, Patna city to know the cyclic behavior, estimate the dynamic soil properties and the effect of relative density, confining pressure and frequency of loading on the cyclic behavior of the soil tested. The test results indicate the cyclic strength of Allahabad soil is less than Patna and Kanpur soil. The Allahabad soil with 80% sand, 10% silt and clay each is more prone to liquefaction than Kanpur soil (82% silt, 16% clay and 2% sand) and Patna soil (10% Kankar, 95% sand, 5% silt). This study indicates soils having sand with silt percentage are more liquefiable than clean sand or silty soil. It can be concluded that the soil of Allahabad and Patna city is more prone to liquefaction than Kanpur soil.
Rethinking the defining contextualization of in-work poverty: the challenge of individualism and globalization
Authors: Liu Jinghong 
Published: January 2022

AbstractGrowing empirical evidence reveals the dramatic expansion in the risk of in-work poverty on a global scale over the last half-century. The current article reviews research on in-work poverty, illustrates how in-work poverty developed from a regional phenomenon into a global issue, and considers recent studies that have reexamined the concept of “in-work poverty” from the original “male family head” to further call on respecting the individual perspective and gender dimension. On the one hand, few studies have provided evidence on the gendered trends in in-work poverty; women’s situation in in-work poverty has not been particularly researched, and the gender dimension is often invisible. On the other hand, the existing literature does not consider this poverty issue much in developing countries, even though this does not mean that in-work poverty in developed countries is only a “side effect.” Hence, an international comparative setting with the gender dimension is needed, and more research is required to explore this construct within the context of the developing world.
Safe perioperative management of major hepatectomy in a patient with portal hypertension after elimination of hepatitis C: a case report
Authors: Hamura Ryoga , Onda Shinji , Shirai Yoshihiro , Yasuda Jungo , Haruki Koichiro , Furukawa Kenei , Sakamoto Taro , Gocho Takeshi , Ikegami Toru 
Published: January 2022

Abstract
Background
The administration of direct-acting antiviral agents in patients with liver cirrhosis and hepatitis C has been shown to improve liver function and long-term prognosis after sustained virological response (SVR) is achieved. However, in patients with portal hypertension (PH) at the time of SVR, PH may persist despite improvement in liver function.

Case presentation
An 82-year-old woman with liver cirrhosis due to hepatitis C was treated with direct-acting antiviral agents and achieved SVR. During follow-up, computed tomography revealed a low-density tumor in the left lateral region of the liver with dilation of the left intrahepatic bile duct. Considering the patient’s advanced age and PH persistence with a mild decrease in liver reserve function after SVR, preoperative percutaneous transhepatic portal embolization (PTPE) and partial splenic embolization (PSE) were performed concomitantly. Laparoscopic left hemihepatectomy was performed 8 days after the PTPE and PSE. The patient was discharged 8 days after surgery without any postoperative complications.

Conclusions
Laparoscopic left hemihepatectomy after preoperative management of PH was performed safely in a patient after the elimination of hepatitis C.
Health-related research publications on religious mass gatherings of Muslims: a bibliometric analysis (1980–2020)
Authors: Sweileh Waleed M. 
Published: January 2022

Abstract
Objective
Mass gatherings medicine is an emerging and important field at the national and international health security levels. The objective of the current study was to analyze research publications on religious mass gatherings of Muslims using bibliometric tools.

Methods
Keywords related to religious mass gatherings of Muslims were used in Scopus database. The duration of the study was from January 01, 1980 to December 31, 2020. Examples of keywords used include hajj, Umrah, mass gatherings/Mecca or Makkah, mass gatherings/Karbala, pilgrim/Makkah or Mecca, and others. Bibliometric indicators and mapping were presented.

Results
In total, 509 documents were retrieved. The average number of citations per article was 16.7 per document. Analysis of the retrieved documents indicated that (1) more than 90% of the retrieved documents were about the mass gatherings in Mecca/Makkah; (2) two-thirds of the retrieved documents were research articles; (3) a take-off phase in the number of publications was observed after 2008; (4) the retrieved documents were disseminated in a wide range of journals but specifically the ones in the fields of infectious diseases, public health, and travel medicine; (5) the retrieved documents were mainly published by scholars from Saudi Arabia with collaborative research ties with scholars in the US, France, the UK, and Australia; (6) Saudi Arabia contributed to more than half of the retrieved documents; and (7) four research themes were found: knowledge, attitude, and practices of pilgrims to Mecca/Makkah, vaccination, etiology of hospital admission among pilgrims, and epidemiology of various types of infectious diseases.

Conclusions
Research on mass gatherings, specifically the Hajj, is emerging. Researchers from the Saudi Arabia dominated the field. Research collaboration between scholars in Saudi Arabia and scholars in low- and middle-income countries is needed and must be encouraged since these countries have weaker health systems to screen, monitor, and control the spread of infectious diseases because of the Hajj season.
Transparency in port governance: setting a research agenda
Authors: Brooks Mary R. , Knatz Geraldine , Pallis Athanasios A. , Wilmsmeier Gordon 
Published: January 2022

AbstractThis study examines the concept of transparency as practiced (or not) in ports. It explores the availability of information to the general public and port stakeholders through the ports’ most public face—its website, studying public ports in North America, Europe, and Latin America and the Caribbean. This exploratory research centred on identifying the parameters that would be useful for the general public to have sufficient information to monitor, review and in many cases, participate in the decision-making processes carried out by the port authority, irrespective of whether or not laws mandate such disclosure. Fifty-one items were identified for the examination of each port’s website, focusing primarily on four major categories: decision-making governance, port communications and accessibility, transparency in reporting and in port operational activities. Using nine items as proxies for the 51, the research reveals uneven levels of port transparency both regionally and by governance model. The study reveals a need for increasing and differentiating the existing levels and standards of transparency in the governance of the port industry, and for greater consistency between ports within and across regions. The study concludes with a research agenda for future research.
Review of studies of blockchain technology effects on the shipping industry
Authors: Gerakoudi-Ventouri Kelly 
Published: January 2022

AbstractDecision-making is a prolific research area in the internet era, which has propelled globalization and the virtual elimination of many country border barriers. However, effective decision-making in the shipping industry is a time consuming and often complicated process. Digital evolution has provided new innovative organizational operation methods. Blockchain technology—a basic component of the Fourth Industrial Revolution—is one such innovation that promises to alter the process of decision-making. However, only a few academic studies have explored the decision-making aspect of blockchain technology. Moreover, there is a dearth of comprehensive research on how blockchain affects decisions in the shipping industry. This study explored how this novice technology can address issues, such as vast documentation and information asymmetry in the shipping industry. Specifically, grounded theory was used to qualitatively investigate extant practices and examine the potential impact of blockchain technology on decision-making in the shipping industry and the potential of using blockchain technology to emancipate decision-making. The study results indicate that the instant and reliable data-sharing capability of blockchain can significantly impact the shipping industry, while transforming its decision-making processes.
Impact of demographic, clinical, and treatment compliance characteristics on quality of life of Venezuelan patients with systemic lupus erythematosus
Authors: Carrión-Nessi Fhabián S. , Marcano-Rojas María V. , Romero Arocha Sinibaldo R. , Mendoza Millán Daniela L. , Forero-Peña David A. , Antuarez-Magallanes Allen W. , Al Snih Soham , Rodríguez Martín A. , Fuentes-Silva Yurilís J. 
Published: January 2022

Abstract
Background
We have here assessed the impact of demographic, clinical, and treatment compliance characteristics on health-related quality of life (HRQoL) of Venezuelan patients with systemic lupus erythematosus (SLE). We have used a disease-specific questionnaire, the Lupus Quality of Life (LupusQoL), validated in our patient population, to measure HRQoL.

Methods
A cross-sectional study was conducted among 100 patients with SLE from outpatient clinics. Patients completed a form with demographic, clinical, and treatment compliance data, and the LupusQoL questionnaire. HRQoL was classified as better or worse according to previously established cut-off points for this patient population. Spearman’s r test was used to determine the correlations between age, years of education, disease duration, SLEDAI, and SLICC-DI with the eight domains of the LupusQoL. Mann–Whitney U test was used to compare the HRQoL between the two groups of patients according to treatment compliance. Binomial logistic regression using the backward stepwise selection method was performed to identify the risk factors associated with each of the eight domains of the LupusQoL among patients with inactive (SLEDAI < 4) and active (SLEDAI ≥ 4) SLE.

Results
HRQoL of our patients was classified as better in all domains of the LupusQoL. Age correlated negatively with all domains of the LupusQoL, except with “burden to others”, and disease activity correlated negatively with all domains of the LupusQoL, except with “intimate relationships” and “burden to others” (p < 0.05). Patients who fully complied with indicated treatment had higher scores in “physical health” domain compared to patients who did not comply with at least one of the prescribed medications (p < 0.05). In patients with active SLE, a risk factor associated with worse “planning” and “intimate relationships” was advanced age, while having had SLE flare-ups in the previous six months was a risk factor associated with worse “physical health” (p < 0.05).

Conclusion
Age and disease activity were negatively correlated with almost all domains of the LupusQoL, and treatment compliance was associated with higher score in the “physical health” domain. Disease control and treatment compliance should be the main goals for a better HRQoL in our patients with SLE.
Effects of short-term environmental stresses on the onset of cannabinoid production in young immature flowers of industrial hemp (Cannabis sativa L.)
Authors: Park Sang-Hyuck , Pauli Christopher S. , Gostin Eric L. , Staples S. Kyle , Seifried Dustin , Kinney Chad , Vanden Heuvel Brian D. 
Published: January 2022

AbstractBackgroundsCannabis sativaL. produces at least 120 cannabinoids. Although genetic variation is the main factor in cannabinoid production, the effects of short-term environmental stresses in the early flowering stage remains largely unknown.MethodsTo investigate the effects of short-term environmental stresses on the onset of cannabinoid production in young immature flowers, a hemp variety, Green-Thunder (5–8% CBD/mg of dry weight), was treated with mechanical damage, insect herbivory, extreme heat, or drought stress for 5–7 days during the first 2 weeks of flowering. Three hemp tissues, including flowers, leaves, and stems, were collected from hemp grown under these stress conditions at multiple time points during the first 2 weeks after transition to the short photoperiod and analyzed using high pressure liquid chromatography to quantify phytocannabinoids including cannabigerolic acid (CBGA), cannabigerol (CBG), cannabidiolic acid (CBDA), cannabidiol (CBD), Δ-tetrahydrocannabinolic acid (THCA), Δ-tetrahydrocannabinol (THC), and cannabinol (CBN).ResultsThe 5 days of mechanical wounding did not affect the production of any of the cannabinoids during the initial stage of flowering. However, after 5 days of herbivore treatment, there was a significant difference in concentration between day 1 and day 6 of CBGA (control: 308 μg/g; treatment – 24 μg/g), CBG (control: 69 μg/g; treatment: 52 μg/g), and CBD (control: 755 μg/g; treatment: 194 μg/g) between the control and treatment plants. The 7 days of heat treatment at 45–50oC significantly reduced the production of CBGA during this observed window (control: 206 μg/g; treatment: 182 μg/g) and CBG (control: 21 μg/g; treatment: − 112 μg/g). Notably, the largest change was observed after 7 days of drought stress, when plants showed a 40% greater accumulation of CBG (control: 336 μg/g; treatment: 622 μg/g), and a significant decrease (70–80%) in CBD (control: 1182 μg/g; treatment: 297 μg/g) and THC amounts (control: 3927 μg/g; treatment: 580 μg/g).ConclusionsAlthough this observation is limited in the early flowering stage, the common field stresses are adequate to induce changes in the cannabinoid profiles, particularly drought stress being the most impactful stress for hemp flower initiation with the altering the cannabinoid production by decreasing CBD and THC accumulation while increasing CBG by 40%.
Therapy development for spinal muscular atrophy: perspectives for muscular dystrophies and neurodegenerative disorders
Authors: Jablonka Sibylle , Hennlein Luisa , Sendtner Michael 
Published: January 2022

AbstractBackgroundMajor efforts have been made in the last decade to develop and improve therapies for proximal spinal muscular atrophy (SMA). The introduction of Nusinersen/Spinraza™ as an antisense oligonucleotide therapy, Onasemnogene abeparvovec/Zolgensma™ as an AAV9-based gene therapy and Risdiplam/Evrysdi™ as a small molecule modifier of pre-mRNA splicing have set new standards for interference with neurodegeneration.Main bodyTherapies for SMA are designed to interfere with the cellular basis of the disease by modifying pre-mRNA splicing and enhancing expression of the Survival Motor Neuron (SMN) protein, which is only expressed at low levels in this disorder. The corresponding strategies also can be applied to other disease mechanisms caused by loss of function or toxic gain of function mutations. The development of therapies for SMA was based on the use of cell culture systems and mouse models, as well as innovative clinical trials that included readouts that had originally been introduced and optimized in preclinical studies. This is summarized in the first part of this review. The second part discusses current developments and perspectives for amyotrophic lateral sclerosis, muscular dystrophies, Parkinson's and Alzheimer's disease, as well as the obstacles that need to be overcome to introduce RNA-based therapies and gene therapies for these disorders.ConclusionRNA-based therapies offer chances for therapy development of complex neurodegenerative disorders such as amyotrophic lateral sclerosis, muscular dystrophies, Parkinson’s and Alzheimer’s disease. The experiences made with these new drugs for SMA, and also the experiences in AAV gene therapies could help to broaden the spectrum of current approaches to interfere with pathophysiological mechanisms in neurodegeneration.
Performance evaluation of digital mammography, digital breast tomosynthesis and ultrasound in the detection of breast cancer using pathology as gold standard: an institutional experience
Authors: Joshi Pranjali , Singh Neha , Raj Gaurav , Singh Ragini , Malhotra Kiran Preet , Awasthi Namrata Punit 
Published: January 2022

Abstract
Background
Mammography is the primary imaging modality for diagnosing breast cancer in women more than 40 years of age. Digital breast tomosynthesis (DBT), when supplemented with digital mammography (DM), is useful for increasing the sensitivity and improving BIRADS characterization by removing the overlapping effect. Ultrasonography (US), when combined with the above combination, further increases the sensitivity and diagnostic confidence. Since most of the research regarding tomosynthesis has been in screening settings, we wanted to quantify its role in diagnostic mammography. The purpose of this study was to assess the performance of DM alone vs. DM combined with DBT vs. DM plus DBT and ultrasound in diagnosing malignant breast neoplasms with the gold standard being histopathology or cytology.

Results
A prospective study of 1228 breasts undergoing diagnostic or screening mammograms was undertaken at our institute. Patients underwent 2 views DM, single view DBT and US. BIRADS category was updated after each step. Final categorization was made with all three modalities combined and pathological correlation was done for those cases in which suspicious findings were detected, i.e. 256 cases. Diagnosis based on pathology was done for 256 cases out of which 193 (75.4%) were malignant and the rest 63 (24.6%) were benign. The diagnostic accuracy of DM alone was 81.1%. Sensitivity, Specificity, PPV and NPV were 87.8%, 60%, 81.3% and 61.1%, respectively. With DM + DBT the diagnostic accuracy was 84.8%. Sensitivity, Specificity, PPV and NPV were 92%, 56.5%, 89% and 65%, respectively. The diagnostic accuracy of DM + DBT + US was found to be 85.1% and Sensitivity, Specificity, PPV and NPV were 96.3%, 50.7%, 85.7% and 82%, respectively.

Conclusion
The combination of DBT to DM led to higher diagnostic accuracy, sensitivity and PPV. The addition of US to DM and DBT further increased the sensitivity and diagnostic accuracy and significantly increased the NPV even in diagnostic mammograms and should be introduced in routine practice for characterizing breast neoplasms.
Negative renal angiography with subsequent denied angioembolization: findings in a series of 180 patients at a tertiary interventional uroradiology unit
Authors: Farg Hashim Mohamed , Elawdy Mohamed Mohamed , Soliman Karim Ali , Badawy Mohamed Ali , Elsorougy Ali , Mohsen Tarek , El-Diasty Tarek , Abdelhamid Abdalla 
Published: January 2022

Abstract
Background
Renal arterial embolization (RAE) is considered to be a safe and effective method for treating a variety of renal lesions and pathology. It is the optimal method not only to stop bleeding, but to preserve renal parenchyma and renal function. Patients who are scheduled to RAE who showed negative catheter angiography with the procedure subsequently denied have a special concern because they are subjected to unnecessary procedure with its complications and didn’t get its benefits. This circumstance is infrequently reported in the literature, and that compelled us to identify the predictors of negative renal angiography findings that would result in a failure to undertake RAE.

Results
The study included 180 patients (126 males; 70%) with a mean ± SD age of 44 ± 14 years. Iatrogenic causes were the most common indication for RAE (108 of 180; 60%), while spontaneous unknown reasons constituted (17 of 180 patients; 9%). Angiography showed various lesions in 148 patients: pseudoaneurysm (80 of 148; 54%), tumours (28 of 148; 19%), arteriovenous (AV) fistulas (22 of 148; 15%)
and both pseudoaneurysm and AV fistulas (18 of 148; 12%). However, in the remaining 32 of 180 patients (18%) no lesions were identified on renal angiography and RAE procedures were not undertaken. On bivariate analysis, neither gender, side of the lesions, haematuria prior to RAE, or renal artery anatomy were predictors for negative angiography. However, the indication for RAE (spontaneous unknown reasons) of renal haemorrhage was the only predictor for negative angiography (9/17 (53%), P = 0.001).

Conclusion
Patients scheduled for RAE may show negative findings with no lesions on renal angiography. Among the different indications for RAE, patients with spontaneous (unknown) have the highest probability (53%) of being associated with negative renal angiography findings, however, those with renal tumours and post-traumatic causes have a low probability. In those patients with spontaneous (unknown), conservative management should be the initial treatment of choice in order to avoid unnecessary RAE and its associated complications.
The value of inflow inversion recovery MRI for the diagnosis of transplant renal artery stenosis: comparison with digital subtraction angiography
Authors: Li Hongxia , Shao Guangrui , Zhao Yuan , Zhong Hai 
Published: January 2022

Abstract
Background
To date, few data on the assessment of transplant renal artery stenosis (TRAS) by using inflow inversion recovery (IFIR) are available. The aims of this study was to evaluate the feasibility of IFIR in the assessment of TRAS using Digital Subtraction Angiography (DSA) as the reference.

Results
We retrospectively assessed the IFIR of 195 transplant renal arteries. The IFIR images for 194/195 arteries were judged to be of excellent, good, or moderate quality, and 1/195 was not diagnostic. There were 100 arteries with TRAS, of which 27 were subjected to DSA. The stenosis percentages were divided into five grades. Using DSA images, the TRAS in 27 patients were estimated as grade 1 (2, 7.4%), grade 2 (8, 29.6%), grade 3 (10, 37.0%), grade 4 (7, 25.9%) and grade 5 (0, 0%). In comparison, the TRAS was shown to be grade 1 (1, 3.7%), grade 2 (8, 29.6%), grade 3 (9, 33.3%), grade 4 (9, 33%) and grade 5 (0, 0%) in the IFIR images. The nonparametric Wilcoxon signed-rank test was used to compare IFIR with DSA. In addition, a Bland–Altman plot was used to estimate the agreement between IFIR and DSA measurements. There was no significant difference between IFIR and DSA measurements (p < 0.05).

Conclusions
Relative to the reference DSA, IFIR was shown to be noninvasive, accurate for the diagnosis and evaluation of TRAS.