bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trastuzumab Deruxtecan in Anti–Human Epidermal Growth Factor Receptor 2 Treatment–Naive Patients With Human Epidermal Growth Factor Receptor 2–Low Gastric or Gastroesophageal Junction Adenocarcinoma: Exploratory Cohort Results in a Phase II Trial
Authors: Yamaguchi Kensei , Bang Yung-Jue , Iwasa Satoru , Sugimoto Naotoshi , Ryu Min-Hee , Sakai Daisuke , Chung Hyun Cheol , Kawakami Hisato , Yabusaki Hiroshi , Lee Jeeyun , Shimoyama Tatsu , Lee Keun-Wook , Saito Kaku , Kawaguchi Yoshinori , Kamio Takahiro , Kojima Akihito , Sugihara Masahiro , Shitara Kohei 
Published: November 2022

PURPOSE To investigate efficacy and safety of trastuzumab deruxtecan (T-DXd) in human epidermal growth factor receptor 2 (HER2)–low gastric or gastroesophageal junction (GEJ) adenocarcinoma. METHODS Patients with locally advanced or metastatic HER2-low (cohort 1, immunohistochemistry 2+/in situ hybridization–negative; cohort 2, immunohistochemistry 1+) gastric/GEJ adenocarcinoma treated with at least two prior regimens, including fluoropyrimidine and platinum, but anti-HER2 therapy naive, received T-DXd 6.4 mg/kg intravenously once every 3 weeks. The primary end point was confirmed objective response rate by independent central review. RESULTS Among 21 patients enrolled in cohort 1 and 24 enrolled in cohort 2, 19 and 21 patients, respectively, had central HER2 confirmation, received T-DXd, and had measurable tumors at baseline. The confirmed objective response rate was 26.3% (95% CI, 9.1 to 51.2) from five partial responses in cohort 1 and 9.5% (95% CI, 1.2 to 30.4) from two partial responses in cohort 2. Thirteen patients (68.4%) in cohort 1 and 12 (60.0%) in cohort 2 experienced reduced tumor size. The median overall survival was 7.8 months (95% CI, 4.7 to nonevaluable) in cohort 1 and 8.5 months (95% CI, 4.3 to 10.9) in cohort 2; the median progression-free survival was 4.4 months (95% CI, 2.7 to 7.1) and 2.8 months (95% CI, 1.5 to 4.3), respectively. The most common grade ≥ 3 treatment-emergent adverse events in cohorts 1 and 2 were anemia (30.0% and 29.2%), decreased neutrophil count (25.0% and 29.2%), and decreased appetite (20.0% and 20.8%). Drug-related interstitial lung disease/pneumonitis occurred in one patient in each cohort (grade 1 or 2). No drug-related deaths occurred. CONCLUSION This study provides preliminary evidence that T-DXd has clinical activity in patients with heavily pretreated HER2-low gastric/GEJ adenocarcinoma.
Unliterary History: Toni Morrison, The Black Book, and “Real Black Publishing”
Authors: Brier Evan 
Published: November 2022

Abstract
How should Toni Morrison’s work as a Random House editor be understood? How does it figure, that is, in the larger contexts of literary history, publishing history, and the history of African American expression? Positioning Morrison’s editorial work in relation to the corporate takeover of American publishers and the rise of Black studies programs, this article reconstructs a lost moment in both cultural history and business history. Starting with the story of The Black Book, a “scrapbook-history” of African American experience edited by Morrison and published by Random House in 1974, this article examines the fleeting institutional context that made not just The Black Book but a body of African American writing possible. In doing so, it makes a case for reconsidering how changes to the publishing business, late in the twentieth century, shaped American literary history.
What the Afterlife ofSCUMCan Teach Us about Autotheory
Authors: Ioanes Anna 
Published: November 2022

AbstractThe emerging genre of autotheory has been tied to a longer lineage of feminist and queer writing. Valerie Solanas’s SCUM Manifesto (1967) forms an important context for contemporary autotheoretical practices not only as an influence but also as a cautionary tale. Published in 1967, just one year before its author shot Andy Warhol, the SCUM Manifesto was quickly overdetermined by readings that saw the shooting as a fulfillment of the manifesto’s vision, rewriting the manifesto as a kind of autotheory in reverse. Tracing SCUM’s afterlife in a range of cultural texts, including Riot grrrl zines and Andrea Long Chu’s autotheoretical work Females (2019), reveals consistent anxieties about the relationship between the manifesto and the shooting. As a parallel cultural formation arising alongside autotheory, SCUM’s afterlife shows how anxieties about interpretation drive the autotheoretical impulse.
Fashioning the Soul in Colonial Río de la Plata: Religious Education in the Guaraní Missions, 1609–1768
Authors: Huffine Kristin 
Published: November 2022

Abstract
This article examines how the 1705 Guaraní translation and publication of Juan Eusebio Nieremberg’s On the Difference between the Temporal and Eternal in Río de la Plata’s colonial missions provides evidence of Jesuit instruction in advanced spiritual formation as well as more limited forms of devotional training among Guaraní Indians. The book was translated for a growing population of elite Indigenous readers and for public readings among Indians without preparation in literacy in the missions. Introducing mission residents to the practice of spiritual exercises similar to those originally designed by Ignatius Loyola in his sixteenth-century handbook, the Guaraní Nieremberg imprint and its accompanying engravings reveal Jesuit methods of training in spiritual formation as well as efforts to provide for the development of Guaraní-Christian subject formation. The article also examines how the Guaraní brought their own knowledge of the soul-word and its close connections to language, dream songs, and speech to the Jesuit project of spiritual discernment and Guaraní-Christian subject formation.
CT coronary angiography first prior to rapid access chest pain clinic review: a retrospective feasibility study
Authors: Graby John , Murphy David , Metters Rhys , Parke Kady , Jones Samantha , Ellis Dawn , Khavandi Ali , Carson Kevin , Lowe Rob , Rodrigues Jonathan C.L. 
Published: November 2022

Objectives: Since rapid access chest pain clinics (RACPC) were established to streamline stable chest pain assessment, CT coronary angiography (CTCA) has become the recommended investigation for patients without known coronary artery disease (CAD), with well-defined indications. This single-centre retrospective study assessed the feasibility of General Practice (GP)-led CTCA prior to RACPC. Methods: RACPC pathway patients without pre-existing CAD electronic records were reviewed (September–October 2019). Feasibility assessments included appropriateness for RACPC, referral clinical data vs RACPC assessment for CTCA indication and safety, and a comparison of actual vs hypothetical pathways, timelines and hospital encounters. Results: 106/172 patients screened met inclusion criteria (mean age 61 ± 14, 51% female). 102 (96%) referrals were ‘appropriate’. No safety concerns were identified to preclude a GP-led CTCA strategy. The hypothetical pathway increased CTCA requests vs RACPC (84 vs 71), whilst improving adherence to guidelines and off-loading other services. 22% (23/106) had no CAD, representing cases where one hospital encounter may be sufficient. The hypothetical pathway would have reduced referral-to-diagnosis by at least a median of 27 days (interquartile range 14–33). Conclusion: A hypothetical GP-led CTCA pathway would have been feasible and safe in a real-world RACPC patient cohort without pre-existing CAD. This novel strategy would have increased referrals for CTCA, whilst streamlining patient pathways and improved NICE guidance adherence. Advances in knowledge: GP-led CTCA is a feasible and safe pathway for patients without pre-existing CAD referred to RACPC, reducing hospital encounters required and may accelerate time to diagnosis. This approach may have implications and opportunities for other healthcare pathways.
Multi-stage ytterbium fiber-amplifier seeded by a gain-switched laser diode
Authors: Ryser M. , Pilz S. , Burn A. , Romano V. 
Published: November 2022

We demonstrated all-fiber amplification of 11 ps pulses from a gain-switched laser diode at 1064 nm. The diode was driven at a repetition rate of 40 MHz and delivered 13 µW of fiber-coupled average output power. For the low output pulse energy of 325 fJ we have designed a multi-stage core pumped pre-amplifier in order to keep the contribution of undesired amplified spontaneous emission as low as possible. By using a novel time-domain approach for determining the power spectral density ratio (PSD) of signal to noise, we identified the optimal working point for our pre-amplifier. After the pre-amplifier we reduced the 40 MHz repetition rate to 1 MHz using a fiber coupled pulse-picker. The final amplification was done with a cladding pumped Yb-doped large mode area fiber and a subsequent Yb-doped rod-type fiber. With our setup we reached a total gain of 73 dB, resulting in pulse energies of >5.6 µJ and peak powers of >0.5 MW. The average PSD-ratio of signal to noise we determined to be 18/1 at the output of the final amplification stage.
The PFAPA syndrome: review on diagnosis and management
Authors: Zuchniak Paweł , Godek Grzegorz , Klajda Katarzyna , Sidorczuk Piotr , Król Olgierd , Wysokińska Olga 
Published: November 2022

Introduction and purpose: Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA syndrome) is the most common periodic fever condition in child age. Discussed syndrome is generally a self-limited condition, but it can significantly decrease the quality of child’s life. It can be also challenge for parents, as well as medical professionals. Knowledge of the syndrome is very important among many specialists because early detection is the basis of the correct differentia and proper treatment. Many researches has been made to explain the genetic and immunologic elements which play a significant role in the pathogenesis of PFAPA, but it is not fully undestood. This review will focus on current knowledge regarding the pathogenesis of PFAPA, as well as surgical and conservative treatment strategies.
Material and methods: This review was based on available data collected in the PubMed database and published between 2013 and 2022. The study was conducted by reviewing key words as follows: "PFAPA","treatment", "diagnosis","tonsillectomy".
Results: The diagnosis of PFAPA syndrome consists of a typical clinical presentation, but sometimes diagnosis of this syndrome can be problematic. Some clinical criteria can be useful. We have vary of treatment arms depends on clinical targets. Depite that PFAPA is self limiting syndrome which can dissappear in later years of children’s life.

Conclusions: PFAPA syndrom is rare disease, but is very important to put emphasis on knowledge about it. Early diagnosis of this syndrome can make physicians send patient to specialized ward, and it will be possible to start proper and efficient treatment. It is a question of the future that we will get more patophysiologic knowledge about this disease.
The New Citizenship: Unconventional Politics, Activism, and Service, Craig Rimmerman (ed.) (2018)
Authors: Rubin Jee 
Published: November 2022

Review of: The New Citizenship: Unconventional Politics, Activism, and Service, Craig Rimmerman (ed.) (2018)
New York and London: Routledge, 208 pp.,
ISBN 978-0-81334-457-7, h/bk, $69
Analisis Kesalahan Berbahasa dalam Platform Berita Media Sosial
Authors: Alfarisy Fitri , Maghfirah Maghfirah , Devinsky Enrika , Hastiani Rr Kamila 
Published: November 2022

Bahasa Indonesia sudah banyak diminati oleh orang-orang asing. Banyak pelajar dari berbagai negara yang menempuh pendidikan dengan belajar bahasa Indonesia melalui program-program yang telah dikembangkan oleh pemerintah. Sosial media menjadi salah satu tempat mereka belajar bahasa Indonesia, salah satunya dengan membaca artikel dan berita dalam bahasa Indonesia. Salah satu media sosial yang populer di Indonesia adalah LINE TODAY. Namun tak jarang ditemukan kesalahan berbahasa pada berita-berita di sosial media, baik kesalahan yang tidak sengaja maupun kesalahan yang murni dari penulis akibat ketidak telitiannya. Penelitian ini ditujukan untuk mengetahui kesalahan apa saja dan seberapa banyak jenis kesalahan berbahasa pada sosial media terutama LINE TODAY periode September 2021, hal ini agar para penutur asing yang sedang mempelajari bahasa Indonesia juga dapat mengetahui penulisan bahasa Indonesia yang baik dan benar. Jenis penelitian ini adalah penelitian deskriptif kualitatif. Teknik pengumpulan data dalam penelitian ini memakai teknik simak dan catat. Teknik analisis data yang dilakukan berupa pengumpulan, pencatatan, klasifikasi, dan mendeskripsikan pembenarannya. Berdasarkan hasil penelitian ini ditemukan empat bidang kesalahan berbahasa pada bidang linguistik, yaitu: (1) ejaan, (2) morfologi, (3) sintaksis, dan (4) diksi. Dengan adanya penelitian ini, diharapkan kedepannya berita-berita yang dipublikasi dapat memberikan pengetahuan kepada pembaca dengan penulisan yang benar sesuai kaidah bahasa Indonesia.
Pengaruh Indeks Prestasi Kumulatif Mahasiswa Program Studi S-1 Ilmu Perpustakaan, Fakultas Ilmu Budaya, Universitas Diponegoro Angkatan 2018 terhadap Kemampuan Literasi Informasi
Authors: Husna Putri Nabila , Jumino Jumino 
Published: November 2022

Penelitian ini bertujuan untuk mengetahui pengaruh Indeks Prestasi Kumulatif (IPK) mahasiswa Program Studi S-1 Ilmu Perpustakaan, Fakultas Ilmu Budaya, Universitas Diponegoro Angkatan 2018 terhadap kemampuan literasi informasi. Teori yang digunakan untuk mengukur kemampuan literasi informasi adalah standar literasi informasi ACRL. Penelitian ini menggunakan metode kuantitatif analisis deskriptif dengan path analysis. Populasi dalam penelitian ini adalah mahasiswa Program Studi S-1 Ilmu Perpustakaan angkatan 2018 dengan sampel sebesar 90 responden. Hasil penelitian ini menunjukan bahwa tingkat pengaruh berdasarkan indikator menentukan sifat dan cakupan informasi yang dibutuhkan memperoleh mean tertinggi sebesar 4,22 dan dalam kategori sangat berpengaruh, indikator mengidentifikasi informasi yang dibutuhkan secara efektif dan efisien memperoleh mean tertinggi sebesar 4,07 dan dalam kategori berpengaruh, indikator memberikan evaluasi terhadap informasi dan sumber-sumbernya secara kritis memperoleh mean tertinggi sebesar 4,23 dan dalam kategori sangat berpengaruh, indikator menggunakan informasi untuk menyelesaikan tujuan tertentu memperoleh mean tertinggi sebesar 4,02 dan dalam kategori berpengaruh, indikator mengetahui aspek ekonomi, hukum, dan sosial yang bersangkutan dengan penggunaan informasi memperoleh mean tertinggi sebesar 4,21 dan dalam kategori sangat berpengaruh. Berdasarkan hasil analisis data diketahui bahwa indeks prestasi kumulatif mahasiswa memiliki pengaruh terhadap kemampuan literasi informasi.
Perilaku Informasi Mahasiswa Fakultas Ilmu Budaya Universitas Diponegoro dalam Pemanfaatan Fitur Trending Topic Twitter Sebagai Pemenuhan Kebutuhan Informasi
Authors: Rufaidha Nabiella Fikri , Irhandayaningsih Ana 
Published: November 2022

Perilaku Informasi merupakan salah satu kajian Ilmu Perpustakaan dan Informasi yang menggali dan mengeksplorasi tingkah laku manusia dalam memenuhi kebutuhan akan informasi dan bagaimana seseorang atau individu melakukan pencarian informasi. Penelitian ini mengkaji tentang perilaku informasi mahasiswa Fakultas Ilmu Budaya Universitas Diponegoro dalam pemanfaatan Twitter khususnya fitur trending topic Twitter. Metode yang digunakan adalah metode kualitatif dengan pengumpulan data wawancara semi terstruktur dengan sembilan (9) informan yang berasal dari mahasiswa Fakultas Ilmu Budaya Universitas Diponegoro dan observasi. Data yang diperoleh dianalisis menggunakan thematic analysis untuk mengidentifikasi pola perilaku informan. Hasil analisis menunjukkan tiga tema terkait Perilaku Informasi mahasiswa Fakultas Ilmu Budaya Universitas Diponegoro dalam pemanfaatan fitur trending topic Twitter sebagai pemenuhan kebutuhan informasi. Hasil penelitian ini menunjukan bahwa Mahasiswa Fakultas Ilmu Budaya Universitas Diponegoro memiliki dorongan atau motivasi dalam pemenuhan kebutuhan informasi melalui fitur trending topic Twitter sehingga memunculkan suatu kebutuhan informasi yang berbeda-beda, seperti kebutuhan informasi akan hiburan, berita, dan informasi terkini. Kebutuhan informasi menimbulkan suatu penelusuran informasi trending topic Twitter, tentang bagaimana perilaku mahasiswa Fakultas Ilmu Budaya Universitas Diponegoro dalam mencari, mengolah, dan menggunakan informasi yang ada pada fitur trending topic Twitter. Dalam prosesnya terdapat faktor yang mendukung dan menghambat faktor tersebut berupa kelebihan dan kekurangan fitur trending topic Twitter yang dijadikan sebagai sumber informasi. Fitur trending topic memiliki beberapa kelebihan seperti informasi cepat, murah, dan mudah. Adapun untuk kekurangannya yaitu terdapat banyak trending yang tidak jelas dan penyalahgunaan fitur trending topic Twitter. Hasil penelitian ini dapat bermanfaat bagi semua orang khususnya mahasiswa dalam berperilaku dan memanfaatkan fitur trending topic Twitter sebagai sumber informasi untuk pemenuhan kebutuhan informasinya.
PoRi device: portable hand assessment and rehabilitation after stroke
Authors: Wolf Karl , Mayr Andreas , Nagiller Marco , Saltuari Leopold , Harders Matthias , Kim Yeongmi 
Published: November 2022

Abstract
Frequent rehabilitation exercises can accelerate the recovery of patient’s hand impairments after stroke. In conjunction with conventional therapy, the use of robot-assisted training has been proposed to increase the frequency of the latter, thus improving the overall recovery of patients. However, the COVID-19 pandemic has reduced or even halted related programs in clinical rehabilitation centers that often utilize costly, complex, and non-transportable robotic devices. A possible therapy alternative is using low-cost in-home solutions which integrate well in home-based settings due to reduced size, weight, and complexity. Therefore, we propose a new portable hand training and assessment device which supports hand opening/closing and wrist exercises. The device also enables tasks related to the identification of vibration stimuli to be used both for training as well as for assessment of sensory-motor hand function of patients. To this end, a cable-driven capstan transmission mechanism, a controller to regulate the extension angle, and touch pads equipped with vibration motors were designed and integrated into a hand-held device. Initial user studies indicate that the prototype can support stroke patients in extending their fingers. In further experiments targeting the identification of vibration stimuli, assessment results comparable with those obtained via a standard clinical somatosensory assessment test were achieved. Given these initial findings, our low-cost system shows the potential to allow in-home rehabilitation exercises in daily life, thus maximizing exposure and frequency, even during a forced lockdown caused by a pandemic.
Minimal surfaces with non-trivial geometry in the three-dimensional Heisenberg group
Authors: Dorfmeister Josef F. , Inoguchi Jun-ichi , Kobayashi Shimpei 
Published: November 2022

AbstractWe study symmetric minimal surfaces in the three-dimensional Heisenberg group Nil3using the generalized Weierstrass type representation, the so-called loop group method. In particular, we will present a general scheme for how to construct minimal surfaces in Nil3with non-trivial geometry. Special emphasis will be put on equivariant minimal surfaces. Moreover, we will classify equivariant minimal surfaces given by one-parameter subgroups of the isometry group Iso◦(Nil3) of Nil3.
Synthesis and characterization of ZnO–TiO2–chitosan–escin metallic nanocomposites: Evaluation of their antimicrobial and anticancer activities
Authors: Elderdery Abozer Y. , Alhamidi Abdulaziz H. , Elkhalifa Ahmed M. E. , Althobiti Maryam M. , Tebien Entesar M. A. , Omer Nawal Eltayeb , Hamza Siddiqa M. A. , Alanazi Fehaid , Alzahrani Badr , Subbiah Suresh Kumar , Mok Pooi Ling 
Published: November 2022

Abstract
This work intended to formulate bio-nanocomposites of zinc oxide (ZnO), titanium oxide (TiO2), chitosan, and escin, characterize their physical properties, and evaluate their antimicrobial and anticancer properties. X-ray diffractometers (XRD) and scanning and transmission electron microscopes were applied to characterize the morphology and ultrastructure of chemically synthesized bio-nanocomposites. To investigate the functional groups of bio-nanocomposites, we used Perkin–Elmer spectrometers for Fourier transform infrared (FTIR) analysis and photoluminescence (PL) spectroscopy for PL spectrum analysis. Antimicrobial activities against bacterial and fungal strains were tested with agar well diffusion. Bio-nanocomposites were tested for anticancer effects on a MOLT4 blood cancer cell line using morphological analysis, methyl thiazole tetrazolium assay, apoptosis by acridine orange/ethidium bromide, and mitochondrial membrane potential (ΔΨm). In XRD, FTIR, and PL, the active compounds of ZnO–TiO2, chitosan, and escin peaks were observed. Our bio-nanocomposites demonstrated antimicrobial activity against bacterial and fungal pathogens. The bio-nanocomposite was cytotoxic to MOLT4 cells at an IC50 concentration of 33.4 µg·mL−1. Bio-nanocomposites caused cytotoxicity, changes in cell morphology, and mitochondrial membrane potential degradation, all of which resulted in apoptotic cell death. MOLT4 cells were found to be responsive to bio-nanocomposites based on ZnO–TiO2–chitosan–escin.
Time related changes of affective dimensions and distinct emotions in the interaction with a tablet PC
Authors: Brandenburg Stefan , Spang Robert 
Published: November 2022

AbstractExamining peoples’ affect and emotions over time and their effects on peoples’ behavior are ongoing endeavors in human-computer-interaction (HCI) research. This paper reports an experiment in which participants watched either positive or negative film clips on a tablet PC to enter a positive or negative affective state. Successively, they accomplished four basic system interaction tasks like changing fonts of an app on the same device. Results show that, in line with previous studies, peoples’ general valence ratings quickly reverted to neutral when starting the task accomplishment. At the level of distinct positive emotions, participants’ ratings of hope, joy, and serenity decreased after watching negative film clips. Moreover, amusement, love, and serenity decreased during the interaction with the tablet PC. Amongst the negative emotions, only ratings of sadness increased after watching negative film clips and decreased again after the interaction. Also, participants in the positive film group were slower in executing one of the basic tasks than participants in the negative film group. The findings suggest that only few emotions may be causal for peoples’ ratings of general affect. Results also indicate that negative emotions may help people executing standard tasks, in contrast to positive emotions. Implications for HCI design and research are discussed.