bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells
Authors: Zhou Jie , Peng Cheng , Li Qiuju , Yan Xiaoyu , Yang Liang , Li Mengting , Cao Xiaoyu , Xie Xiaofang , Chen Dayi , Rao Chaolong , Huang Sizhou , Peng Fu , Pan Xiaoqi 
Published: March 2022

Aconitine is one of the main bioactive and toxic ingredients of Aconitum species. Increasingly, aconitine has been reported to induce neurotoxicity. However, whether aconitine has effects on the dopaminergic nervous system remains unclear. In this study, zebrafish embryos at 6-days postfertilization were exposed to aconitine at doses of 0.5, 1, and 2 μM for 24 h, and SH-SY5Y cells were treated with 50, 100, and 200 μM of aconitine for 24 h. Results demonstrated that aconitine treatment induced deformities and enhanced the swimming behavior of zebrafish larvaes. Aconitine exposure suppressed cell proliferation and increased the number of reactive oxygen species and apoptosis in zebrafish larvaes and SH-SY5Y cells. Aconitine altered the levels of dopamine and its metabolites by regulating the expression of genes and proteins related to dopamine synthesis, storage, degradation, and reuptake in vivo and in vitro. Moreover, aconitine activated the AC/cAMP/PKA pathway by activating the dopamine D1 receptor (D1R) and inhibiting the dopamine D2 receptor (D2R) to disturb intracellular calcium homeostasis, eventually leading to the damage of nerve cells. Furthermore, the D1R antagonist SCH23390 and D2R agonist sumanirole pretreatment effectively attenuated the excitatory state of larvaes. Sumanirole and PKA antagonist H-89 pretreatment effectively decreased intracellular Ca2+ accumulation induced by aconitine in vivo. SCH23390 and sumanirole also reduced aconitine-induced cytotoxicity by inhibiting the AC/cAMP/PKA pathway in vitro. These results suggested that dopamine homeostasis imbalance and dopamine receptors (DRs)-mediated AC/cAMP/PKA pathway activation might be vital mechanisms underlying aconitine-induced neurological injury.
The Moderating Effects of Social Media Activities on the Relationship Between Effort-Reward Imbalance and Health and Wellbeing: A Case Study of the Oil and Gas Industry in Malaysia
Authors: Kanwal Noreen , Isha Ahmad Shahrul Nizam 
Published: March 2022

BackgroundSocial media activities affect every aspect of human life, be it personal, social or professional. Previous studies have confirmed the role of social media in affecting health in terms of releasing stress and providing social support. Increased occupational health disorders and increased time spent on social media activities motivate us to investigate this phenomenon in the context of occupational health. Therefore, the objective of this study is to measure the effects of social media activities related to personal and social life as well as work-life on health and wellbeing of office employees, on their job efforts and job rewards, and in moderating the effect of effort-reward imbalance on health and wellbeing.MethodsInitially, to develop constructs related to social media activities, web-based structured interviews were conducted with five office employees working in the oil and gas industry for the last 5 years. Then, using an online questionnaire survey, data was collected from 424 office employees working in the oil and gas industry in Malaysia. Using statistical software for social science (SPSS) and Smart PLS, exploratory factor analysis and confirmatory factor analysis were conducted to identify reliability and validity (discriminant validity, convergent validity and composite validity) of the constructs. Following this, path analysis was conducted and the moderating effects were identified.ResultsSocial media activities related to work-life decrease health and wellbeing by 11% and weaken the negative effect of effort-reward-imbalance on health and wellbeing by 17.6% at a 1% level of significance. The results of social media activities related to personal and social life strengthen the negative effect of effort-reward imbalance on health and wellbeing by 12% and negatively affects health and wellbeing and job rewards by 13, 55%, respectively. The direct effect of effort-reward imbalance and job efforts is significantly negative on health and wellbeing by 59 and 10%, respectively.ConclusionIt is concluded that social media activities of the office employees significantly moderate the effect of effort-reward imbalance on health and wellbeing and intervene in job rewards in the organizations. Hence, the effect of social media activities reduces the health and wellbeing of office employees.
THE IINFLUENCE OF N-CARBAMYLGLUTAMATE ON THE UTILIZATION OF FREE AMMONIA IN THE BODY AND MILK PRODUCTIVITY OF COWS
Authors: Кузнецов А.С. , ОСТРЕНКО К.С. , КУЗНЕЦОВА Т.С. 
Published: March 2022

Кормовая добавка «Алтавим NCG» (добавка c NCG), содержащая N-карбомилглутамат (NCG), повышает эффективность утилизации аммиака и использование азота рациона, что оказывает влияние на увеличение показателей молочной продуктивности. Подтверждено получение положительного результата от применения добавки с NCG в рационе, который содержит сорбенты аммиака и кормовые добавки для повышения транзита белка через рубец. Добавление 20 г на 1 голову в сутки испытуемой добавки в рацион высокопродуктивных коров в условиях сельхозпредприятия уменьшало содержание аммиака в крови на 44,78%, повышало эффективность использования азота корма на 2,1% и увеличивало молочную продуктивность коров на 0,9 кг в сутки по сравнению с контролем. Отмечено, что в опытной группе продуктивность выросла со 180-го по 210-й день лактации и оставалась выше в период наблюдения последействия, чем в начале опыта. Качественные показатели состава молока не изменились. Установлено наличие положительной динамики в сторону снижения количества соматических клеток в опытной группе.
The feed additive "Altavim NCG" containing N-carbomylglutamate (NCG) helps to increase the efficiency of ammonia utilization and the use of nitrogen in the diet, which favorably affects the increase in milk productivity. It was confirmed that a positive result was obtained from the use of an additive with NCG in the diet containing ammonia sorbents and feed additives to increase the transit of protein through the scar. The addition of 20 g per 1 head per day of the tested additive to the diet of highly productive cows in the conditions of an agricultural enterprise reduced the ammonia content in the blood by 44.78%, increased the efficiency of feed nitrogen use by 2.1% and increased the dairy productivity of cows by 0.9 kg per day compared with the control. It was noted that in the experimental group, productivity increased from the 180th to the 210th day of lactation and remained higher during the follow-up period than at the beginning of the experiment. The qualitative indicators of the milk composition have not changed. The presence of positive dynamics towards a decrease in the number of somatic cells in the experimental group was established.
Tinjauan Yuridis Pengadaan Tanah Rumah Sakit Sumber Waras Tahun 2014 untuk Kepentingan Umum oleh Pemerintah Daerah Provinsi DKI Jakarta
Authors: Harun Harun , Fahruddin Muhammad 
Published: March 2022

ABSTRACT

This research discusses the juridical study of land acquisition for the public interest in DKI Jakarta Province. This research uses a normative juridical method with an approach to reviewing laws and regulations and the President's Rule with the aim of exploring the rules governing the implementation of land acquisition for development in the public interest, which can be seen from legal sources, legal subjects, legal objects, characteristics and forms. sanctions, as well as the formulation of the criminal and criminal sanctions itself. The results of this study are in the Province of DKI Jakarta, Indonesia.

Keywords: Juridical Review, Public Interest, Presidential Regulation No.71 of 2012

ABSTRAK

Penelitian ini membahas tentang kajian Yuridis pengadaan Lahan untuk kepentingan umum di Propinsi DKI Jakarta. Penelitian ini menggunakan metode yuridis normatif dengan pendekatan kajian peraturan perundang-undangan dan Peratutan Presiden dengan Tujuuan untuk mendalami tentang aturan yang mengatur tentang Penyelenggaraan Pengadaan tanah bagi pembangunan untuk kepentingan umum, yang dapat dilihat dari sumber hukum, subjek hukum, objek hukum, sifat dan bentuk sanski, serta rumusan pidana dan sanksi pidana itu sendiri. Hasil penelitian ini adalah di Propinsi DKI Jakarta Indonesia.

Kata kunci :Tinjauan Yuridis, Kepentingan Umum, Peraturan Presiden No.71 tahun 2012
Optimalisasi Jalur Evakuasi Tsunami di Kelurahan Lolong Belanti
Authors: Yasman Jorandy 
Published: March 2022

Padang merupakan ibu kota provinsi Sumatera Barat yang memiliki tata ruang yang didominasi pada kawasan pesisir. Kelurahan Lolong Belanti merupakan salah satu daerah dengan tingkat resiko terhadap bencana tsunami. Oleh karena itu, Jln. Beringin Raya perlu melakukan pengoptimalisasikan jalur evakuasi bencana tsunami dan perlu memiliki sistem jalur evakuasi dan ruang untuk evakuasi kebencanaan sebagai bentuk kesiapsiagaan bencana. Penelitian ini bertujuan memberikan gambaran kesiapan masyarakat untuk penyelamatan diri ketika terjadi bencana dan untuk mengetahui persepsi masyarakat tentang jalur evakuasi di Kelurahan Lolong Belanti. Penelitian ini menggunakan pendekatan kualitatif deskriptif, dengan menggunakan pengumpulan data primer berupa wawancara dengan informan yang mengetahui tentang kebencanaan dan pengumpulan data sekunder berupa dokumen-dokumen yang terkait dengan penanggulangan bencana di Kota Padang. Penelitian menghasilkan bahwa kesiapsiagaan dan informasi rambu petunjuk perlu diperbanyak atau ditingkatkan lagi mengenai tentang jalur evakuasi dan apa yang harus dilakukan ketika terjadi bencana masyarakat lolong belanti cukup paham dan mengerti apa yang harus dilakukan
KARAKTER MORFOLOGI DAN TIPE STELE TUMBUHAN PAKU TERESTERIAL DI HUTAN LINDUNG JUWATA KERIKIL KOTA TARAKAN SEBAGAI SUMBER BELAJAR BIOLOGI
Authors: Siska Siska , Marwiyah Marwiyah , Santi Santi , Hasdar Hasdar , Aditiyanto Megita 
Published: March 2022

The goal of this resarch is to identify morphological characters and stele types of terestrial ferns in RPH Barat (Juata Kerikil) Forest. The result of research was analyzed the suitability to biology learning. This research used qualitative approach, and the sampling technique that was used was adaptive sampling. The result showed that the terestrial ferns consist of 12 species. Based on morphometri of frond, Overall, the ferns had many variety in the size. The largest one was Cyathea podophylla, and the smallest one is Trichomanes maximum. Next, Depend on stele type, majority of ferns have Dictyostele, nine of them have this stele type. In addition, the result related to Plant Taxonomy course and Plant Morphology course. Furthermore, the research related in Senior High School Curriculum (Curriculum 2013), especially in Plantae content. Keywords : Morphology, Stele, Terestrial Ferns
IMPLEMENTASI LESSON STUDY DI KELAS IX D PADA MATERI KELISTRIKAN DAN TEKNOLOGI LISTRIK DI LINGKUNGAN UNTUK MENINGKATKAN KEMAMPUAN MINAT DAN HASIL BELAJAR KOGNITIF SISWA SMP NEGERI 2 TARAKAN
Authors: Kunarti Dewi 
Published: March 2022

Abstract: Lesson Study is an effort to improve the learning process and outcomes which is carried out collaboratively and continuously by a group of teachers. One aspect of improving the learning process using the Lesson Study-based CAR approach is the aspect of interest in learning. With the increasing interest in learning possessed by students, it will also have an effect on improving cognitive learning outcomes, especially in this research in class IX D on Electricity and Electrical Technology in the Environment at SMP Negeri 2 Tarakan. The approach used in this research is to follow the research flow Plan, Do, See. Conducted in 3 stages for 4 cycles. The plot, which begins with the planning stage (plan), at this stage, activities to analyze the needs and problems faced in learning are carried out. Furthermore, the implementation stage (do) is carried out, in the second stage, there are two main activities: 1) learning activities carried out by one of the model teachers, and 2) observation or observation activities carried out by other members or the Lesson Study community. And in the last stage, the reflection (see) is carried out after the teacher has learned in the classroom. Based on the research results obtained posttest. In the cognitive learning outcomes the average value in cycle I was 71.68, cycle II 76.06, cycle III 90.14, and cycle IV was 91.09. Furthermore, for the results of interest in learning, the average value in cycle I was 61.61, cycle II 61.94, cycle III 60.05, and cycle IV was 61.75. From the results of these studies, it can be concluded that the implementation of lesson study can increase interest and cognitive learning outcomes of class IX D students of SMP Negeri 2 Tarakan on electricity and electrical technology. Keywords: lesson study, interest, cognitive
ANALISIS MINAT DAN FAKTOR YANG MEMPENGARUHI MINAT BELAJAR SISWA PADA MATA PELAJARAN IPA BIOLOGI KELAS VIII SMP NEGERI 3 TARAKAN
Authors: Afifa Roisatul , Wijarini Fitri , Nursia Nursia 
Published: March 2022

Abstract: This study aimed to analyze students’ interest in learning Biologi and factors that influenced the interest among the eighth grade students of SMP Negeri 3 Tarakan. This survey research used a quantitative descriptive approach. The subjects were 74 students of the SMP Negeri 3 Tarakan, teachers of science subject and parents of students. Data ware collected by distributing online questionnaires with two repetitions, interviewing the teachers and the parents, and observations during learning. The collected data ware analyzed quantitatively and descriptively. The results showed that in the first repetition, the students’ interest level in the material of the digestive system was moderate with a percentage value of 70.27% or a frequency of 52 students. Meanwhile, in the second repetition, students’ interest level on the material of the digestive system was moderate with a percentage value of 66.21% or a frequency of 49 students. Factors that influenced student interest in the first repetition repetition were subject matter (48.64%), facilities and infrastructure (63.51%), student activities with the community (64.78%), categorized as quite influential. In the second repetition, factors that affected student interest were the subject matter (54.05%) and student activities with the community (63.51%), cantegorized as quite influential. So, it could be concluded that the interest of student with two repetitions was in the moderate category, while the dominant factors that influenced their interest were subject matter and student activities with the community. Keywords: analysis, factors that influence interest, Interest in Learning.
People of the ARA
Authors: Усманов Н.В. 
Published: March 2022

В статье рассматривается, как во время голода начала 1920-х годов в советской России работали сотрудники Американской администрации помощи (АРА), искренне желавших спасти жизни бедствующих россиян, роль директора Русской миссии АРА У. Хаскелла в успешной работе этой организации. Гуманитарная деятельность американцев была сопряжена с определенными объективными и субъективными трудностями: имели место недоразумения и конфликты с властями регионов, где работали аровцы. Не принимая большевистский режим, американцы, работавшие в России, все же находили общий язык с ее представителями в интересах спасения людей от голода, а руководство миссии АРА в Москве пыталось наладить экономические связи между Россией и США
This paper examines the work of the American Relief Administration (ARA) in Soviet Russia during the famine in the early 1920s. The organisation's employees were genuinely committed to saving the lives of the Russian people in distress. The study also explores the role of William N. Haskell, Director of the ARA Russian Mission, in the successful organization of the relief efforts. The American humanitarian aid encountered several objective and subjective obstacles, mostly connected to clashes with the Soviet authorities in the regions where the ARA was active. While rejecting the Bolshevik regime, American relief workers in Russia did find cooperate with the authorities to save people from starvation while the APA mission leadership in Moscow tried to establish economic ties between the USA and Russia.
Penser et écrire l’héritage dans la littérature africaine contemporaine
Authors: Berthelot Obali Jalad 
Published: March 2022

Notre propos aimerait, à travers un geste critique, dévoiler quelques morphologies de l’héritage dans la pensée et la création littéraire africaine contemporaine. Il s’agit de mettre en lumière des reprises, des jeux de réinventions débouchant sur une fabrique de nouveaux dispositifs discursifs à partir desquels les auteurs africains contemporains figurent leurs héritages. L’article tente donc de mettre en évidence la textualisation du legs historique, culturel et familial en « situation postcoloniale ».
Des trompe-l’œil de Ramón Gómez de la Serna aux photographies de Chema Madoz
Authors: Strignano Julien 
Published: March 2022

Dans les Œuvres complètes de Ramón Gómez de la Serna nous sommes en présence d’illustrations de l’auteur lui-même pour les textes issus de Gollerías (1946) et Trampantojos (1947). Sont-elles des trompe-l’œil ? L’écriture et l’illustration qui proviennent de la même main ramonienne, posent question. Les interrogations suscitées par ce mode d’expression artistique hybride ont également une portée contemporaine lorsque le photographe madrilène Chema Madoz propose, en 2009, d’illustrer des greguerías inédites de l’auteur.
Le Legs d’Alfred : Doris Lessing, Alfred & Emily
Authors: Regard Frédéric 
Published: March 2022

L’écriture biographique semble chez Doris Lessing moins destinée à saisir la vie passée des parents de l’auteure, qu’à libérer cette dernière de son propre trauma, celui d’une jeune femme ayant dû côtoyer des fantômes qui n’étaient pas les siens, à commencer par l’amputation du père. Inspiré par une méthode « déconstructionniste », cet essai analyse le « sectionnement » qui s’opère dans Alfred & Emily, mais aussi la dialectique qui tend la relation entre texte et photographie, pour finir par repérer l’inconscient linguistique à l’œuvre dans cette reconstruction du passé.
À la frontière des identités perdues : héritages et création artistique dans Tous des oiseaux de Wajdi Mouawad
Authors: Dupois Gaëtan 
Published: March 2022

Cet article propose une lecture plurielle de Tous des oiseaux, l’une des dernières créations de Wajdi Mouawad, problématisée autour de la notion d’héritage. Il s’agira en fait d’observer la manière dont, tout d’abord, l’écrivain est le dépositaire d’un héritage que l’on pourrait peut-être qualifier de « géopolitique », mais également de s’intéresser à la façon dont l’acte de transmission provoque la nécessité d’un recours à la création théâtrale. En ce sens, étudier « les héritages » à l’aune de la fiction sera un moyen d’interroger la fabrique identitaire des personnages mais aussi la manière dont le théâtre peut modifier notre propre rapport au réel et à interroger les relations entre Orient et Occident.
Gangguan Fungsi Hati pada Coronavirus Disease 2019
Authors: Salsabila Tasha , Waleleng Bradley J. , Pandelaki Karel 
Published: March 2022

Abstract: The incidence and death rate of COVID-19 in North Sulawesi Province continues to increase and data regarding abnormal liver function in COVID-19 is not yet available. This study was aimed to obtain the liver function in COVID-19 patients. This was a literature review study using two databases, namely Pubmed and ClinicalKey. Keywords used were abnormal liver function AND COVID-19, elevated alanine aminotransferase AND COVID-19, elevated aspartate aminotransferase AND COVID-19, elevated gamma-glutamyl transferase AND COVID-19, elevated alkaline phosphatase AND COVID-19, elevated total bilirubin AND COVID-19. After being selected, 10 literatures were obtained based on inclusion and exclusion criteria. The results showed that increased liver function often occurred in cases of COVID-19, but the increase did not reach twice of the normal value. The most frequent increases were in GGT, followed by ALT and AST, total bilirubin, and the least was the increase in ALP. All literatures reported that increased liver function was more common in males, and in severe COVID-19 patients reported by eight literatures. Five literatures reported that elevated liver function increased mortality in COVID-19 cases. In conclusion, there are increases in ALT, AST, ALP, GGT, and total bilirubin levels in COVID-19 patients.Keywords: abnormal liver function, COVID-19 Abstrak: Angka kejadian dan angka kematian COVID-19 di Provinsi Sulawesi Utara terus bertambah sedangkan data mengenai gambaran gangguan fungsi hati pada COVID-19 belum tersedia. Penelitian ini bertujuan untuk mengetahui gambaran fungsi hati pada COVID-19. Jenis penelitian ialah literature review dengan pencarian data menggunakan dua database yaitu Pubmed dan ClinicalKey. Kata kunci yang digunakan yaitu abnormal liver function AND COVID-19, elevated alanine aminotransferase AND COVID-19, elevated aspartate aminotransferase AND COVID-19, elevated gamma-glutamyl transferase AND COVID-19, elevated alkaline phosphatase AND COVID-19, elevated total bilirubin AND COVID-19. Setelah diseleksi, didapatkan 10 literatur berdasarkan kriteria inklusi dan eksklusi. Penelitian ini mendapatkan bahwa peningkatan fungsi hati sering terjadi pada kasus COVID-19 namun peningkatannya tidak mencapai dua kali nilai normal. Peningkatan paling sering terjadi pada GGT, diikuti oleh ALT dan AST, bilirubin total, dan paling sedikit yaitu pada peningkatan ALP. Seluruh literatur melaporkan peningkatan fungsi hati lebih sering terjadi pada laki-laki dan pada kasus COVID-19 gejala berat dilaporkan oleh delapan literatur. Lima literatur melaporkan peningkatan fungsi hati meningkatkan mortalitas pada kasus COVID-19. Simpulan penelitian ini ialah, terdapat peningkatan kadar ALT, AST, ALP, GGT, dan bilirubin total pada penderita COVID-19.Kata kunci: gangguan fungsi Hati, COVID-19
PENERAPAN KURIKULUM HABIT DALAM PEMBENTUKAN KARAKTER STUDI DI MI CERDAS NURANI KOTA CIMAHI
Authors: Yanuar Vina 
Published: March 2022

Permasalahan dalam penelitian ini adalah belum tercerminnya karakter manusia yang berkarakter mulai, serta keterampilan sesuai kebutuhan. Upaya pembentukan karakter dengan langkah praktis dalam melaksanakan pendidikan karakter melalui pembiasaan. Karena dalam membentuk karakter perlu ditunjang kecerdasan yang dibentuk untuk anak yaitu. kecerdasan Spiritual, Emosinal dan Intelektual agar tercapainya tujuan pendidikan nasional Disini sekolah Cerdas Nurani membentuk sebuah kurikulum khusus untuk di sekolah, yang diberi nama Kurikulum Habit, tanpa mengenyampingkan kurikulum nasional. Penelitian ini penulis menggunakan metode penelitian kualitatif deskriptif, menganalisis data berdasarkan fakta tertulis dan memperkayanya. Dalam melaksanakan Kurikulum Habit terdapat komponen yang menyertainya, komponen tersebut adalah Tentang Kurikulum Habit, Tujuan, Konten/isi, Metode, pelaksanaan dan evaluasi. Perlunya kolaborasi antara guru di sekolah dan orang tua. Serta pembiasaan yang dilakukan tak hanya dilakukan oleh anak, akan tetapi oleh guru di sekolah yang sudah memiliki program habit yang harus dilaksanakan. Karena pengaruh keteladanan dalam pembentukan karakter sangat berperan penting. Selain keteladanan pembekalan keterampilan yang dimana keterampilan tersebut didapatkan dari habit-habit yang selalu dilatihkan baik di rumah ataupun di sekolah. Maka jika pembiasaan itu dilakukan berulang akan menjadikan karakter pada anak dan menjadi sebuah keterampilan pada anak.