bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family incivility, work alienation beliefs and submissive behaviors among Pakistani employees: the mitigating role of ego resilience
Authors: De Clercq Dirk , Fatima Tasneem , Khan Bushra 
Published: December 2022

PurposeThis research seeks to unpack a relevant, hitherto overlooked connection between employees' perception that family incivility is undermining their work and their displays of submissive behavior. The authors predict and test a mediating role of employees' work alienation beliefs and a moderating role of their ego resilience in this connection.Design/methodology/approachThe research hypotheses were tested with survey data collected in three rounds, separated by three weeks each, among employees who work in the education sector in Pakistan. The statistical analyses relied on the PROCESS macro, which supports the simultaneous estimation of the direct, mediation and moderated mediation effects that underpin the proposed theoretical framework.FindingsAn important reason that victims of disrespectful treatment at home fail to fight for their rights at work is that they develop parallel beliefs of being disconnected from work. This intermediary role of work alienation beliefs is less prominent though when employees can rely on their personal resource of ego resilience.Practical implicationsFor human resource (HR) managers, this research offers a critical explanation, related to a sense of being estranged from work, for why family-induced work hardships might cause employees to exhibit subservient behaviors at work. It further reveals how this process can be contained if employees have the capability to adapt flexibly to different situations.Originality/valueThis study contributes to extant research by explicating how and when family-induced work hardships might escalate into work responses that mirror employees' experiences at home.
Phenotypic plasticity in desiccation physiology of closely related, range restricted and broadly distributed fruit fly species
Authors: Bosua Henrika J. , Weldon Christopher W. , Terblanche John S. 
Published: December 2022

Abstract

Variation in geographical range size among closely related species may result from differences in physiological traits, such as desiccation tolerance, that enable these species to interact with their environment or adapt to new surroundings.

We tested the hypothesis that insect species with a broader geographical range have either a higher basal desiccation tolerance or mount a more plastic response than more narrowly distributed species by exposing four fruit fly species (Ceratitis capitata, Ceratitis rosa, Ceratitis cosyra and Ceratitis podocarpi) to one of three acclimation treatments (control: standard relative humidity (RH) and temperature; desiccation: standard temperature and low humidity; and temperature: low RH and high temperature) and measuring metabolic rate, activity, water loss rates and survival.

The targeted physiological responses differed between species and acclimation treatments. Survival of the widely distributed C. capitata improved by up to 43% after short‐term exposure to high temperature and desiccation (35°C; 0% RH) treatment, while survival in the more narrowly distributed species only improved by 4%–30% after a desiccation treatment (25°C; 0% RH).

Less water was lost by broadly distributed C. capitata through excretion after both high temperature and desiccation treatments, but only activity and respiratory water loss (RWL) were reduced after the temperature treatment, and total water loss and cuticular water loss declined after the desiccation treatment. The narrowly distributed C. rosa also lost less water through excretion after both acclimation treatments but showed reduced cuticular and RWL only after desiccation. While basal tolerance in C. cosyra was high, acclimation responses in this species and C. podocarpi were insignificant in that they did not produce a measurable survival benefit.

Broadly distributed species successfully employed unique combinations of physiological strategies, with some having highly flexible responses to stressful environmental conditions, which ultimately results in beneficial acclimation to enhance survival during dry conditions. By contrast, range restricted species showed limited responses to desiccation stress. Flexible desiccation responses likely contribute to species geographical ranges in changing climate conditions.

Read the free Plain Language Summary for this article on the Journal blog.
Optimized pressurized hot water extraction, HPLC/LC‐MS characterization, and bioactivity of Tetrapleura tetraptera L. dry fruit polyphenols
Authors: Dzah Courage Sedem 
Published: December 2022

AbstractDespite the global preference for green extraction methods in the recovery of plant bioactives, Tetrapleura tetraptera fruit polyphenols (TTP) are yet to receive considerable attention. For the first time, pressurized hot water extraction (PHWE) of TTP was optimized for total phenol content (TPC) and antioxidant activity (AA) using the Box Behnken design of response surface methodology. Predictor variables were time, temperature, and liquid‐to‐solid ratio. An optimum solution with a desirability of 0.805 was selected and parameters were 43 min, 220°C, and 60 ml g−1 liquid‐to‐solid ratio, yielding TPC of 8.92 mg gallic acid equivalent per gram of sample on dry weight basis (GAE g−1 dw−1) and AA of 70.35%. Purified, optimized TTP were characterized and quantified using HPLC/LC‐MS. PHWE mainly extracted rutin (379.04 µg g−1), cyanidin‐3‐O‐glucoside (chloride) (299.55 µg g−1), naringenin 7‐O‐glucoside (240.11 µg g−1), p‐coumaric acid (177.28 µg g−1), isorientin (150.43 µg g−1), and gallic acid (118.06 µg g−1) whereas cyanidin‐3‐O‐glucoside (chloride) (83.27 µg g−1), protocatechuic acid (61.37 µg g−1), rutin (28.03 µg g−1), and gallic acid (22.62 µg g−1) were mainly extracted by hot water extraction, which was a control. PHWE‐obtained TTP showed higher cellular antioxidant activity, cytotoxicity in human liver cancer cell lines (HepG2), and antimicrobial property against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis than control. The potential mechanisms underlying the biological activities of some of the major polyphenols extracted were briefly discussed. Considering the wide use of the T. tetraptera (TT) fruit in Africa in foods and medicine, the use of more efficient green extraction methods such as PHWE is recommended.Practical ApplicationThis study serves as a baseline for optimizing pressurized hot water extraction, purification, identification, and quantification of Tetrapleura tetraptera polyphenols (TTP) and their biological activities, being the first of its kind. The varied biological effects shown can be exploited further for applications of TTP as nutraceutical agents and preservatives in foods in different forms. Also, the high amounts of gallic acid and other phenolic acids and flavonoids confirmed in this study make TTP good candidates for the development of metal–phenol network nanoparticles to enhance adequate solubility and distribution in food systems in light of the above proposed applications.
Effect of Flammulina velutipes polysaccharides on endoplasmic reticulum stress‐mediated apoptosis by activating PLC–IP3 pathway in HepG2 cells
Authors: Ding Miao , Lv Kai , Zhang Dongliang , Fan Wentao , Tsopmejio Ivan Stève Nguepi , Jin Zhouyu , Song Hui 
Published: December 2022

AbstractFlammulina velutipes polysaccharides (FVP) have been proven to induce apoptosis in HepG2 cells. It is well known that endoplasmic reticulum stress (ERS) is involved in apoptosis. However, ERS mediates FVP‐induced apoptosis in HepG2 cells remains unclear. In our study, the results indicated that FVP caused ERS in HepG2 cells. They showed that FVP were water‐soluble polysaccharides with the weight average molecular weight of 1972 kDa, which were mainly composed of mannose, gluconic acid, glucose, galactose, xylose and fructose in a molar ratio of 6.6 : 1.3 : 79.9 : 7.4 : 3.4 : 1.5. After FVP treatment, the expression levels of genes and proteins related to ERS were upregulated. The inhibition of ERS by 4‐phenylbutyric acid (4‐PBA) pretreatment could significantly reduce the role of FVP in inducing apoptosis. We further found the results of immunofluorescence and flow cytometry showing that Ca2+ in the ERS leaked out, and the intracellular Ca2+ concentration increased after FVP treatment. The pretreatment with the phospholipase C (PLC) inhibitor U73122 proved that FVP caused excessive intracellular Ca2+ concentration by activating the phospholipase C–inositol‐1,4,5‐triphosphate (PLC‐IP3) pathway, resulting in ERS, and ultimately leading to apoptosis. In summary, our results indicated that FVP induced ERS‐mediated apoptosis by activating PLC–IP3 pathway in HepG2 cells.Practical ApplicationThis work may suggest that FVP could be used as an adjuvant therapy to anticancer drugs, providing new application prospects and possibilities.
Meta‐analysis: Efficacy and safety of albumin in the prevention and treatment of complications in patients with cirrhosis
Authors: Leache Leire , Gutiérrez‐Valencia Marta , Saiz Luis Carlos , Uriz Juan , Bolado Federico , García‐Erce José Antonio , Cantarelli Lorenzo , Erviti Juan 
Published: December 2022

SummaryIntroductionAlbumin is used in multiple situations in patients with cirrhosis, but the evidence of its benefit is not always clear. The aim was to synthesise the evidence on the efficacy and safety of albumin compared to other treatments or no active intervention in cirrhotic patients.Materials and MethodsWe conducted a systematic review including randomised controlled trials (RCTs) published in MEDLINE, EMBASE and CENTRAL up to May 2022. We assessed all‐cause mortality, liver transplant, cirrhosis complications of any type and serious adverse events (SAEs). Second, AEs, hospital readmission, length of hospital stay, need for paracentesis and quality of life (QoL) were evaluated. Meta‐analyses with Mantel–Haenszel method and random‐effects model were performed.ResultsFifty studies (5118 participants) were included. Albumin was associated with a reduction in mortality in cirrhotic patients with spontaneous bacterial peritonitis (SBP) (RR 0.49, 95% CI 0.32–0.75; low certainty) and hepatic encephalopathy (HE) (RR 0.53, 95% CI 0.34–0.83; low certainty) when compared to no administration of albumin, but not in other scenarios. In general, no additional benefit of albumin was found in liver transplants, SAEs or cirrhosis complications (low/very low certainty). Long‐term administration (>3 months) of albumin led to a reduction in cirrhosis complications (RR 0.75, 95% CI 0.57–0.97; low certainty), hospital readmissions, length of hospital stay, need for paracentesis and improvement of QoL.ConclusionAlbumin may reduce mortality risk in cirrhotic patients with SBP or HE. No benefit was identified in reducing liver transplants or SAEs. Long‐term administration may be associated with a lower risk of cirrhosis complications and need for paracentesis.
Identifying the key genes of Epstein–Barr virus‐regulated tumour immune microenvironment of gastric carcinomas
Authors: Zhou Heng , Jing Shuili , Liu Yu , Wang Xuming , Duan Xingxiang , Xiong Wei , Li Ruohan , Peng Youjian , Ai Yilong , Fu Dehao , Wang Hui , Zhu Yaoqi , Zeng Zhi , He Yan , Ye Qingsong 
Published: December 2022

AbstractThe Epstein–Barr virus (EBV) is involved in the carcinogenesis of gastric cancer (GC) upon infection of normal cell and induces a highly variable composition of the tumour microenvironment (TME). However, systematic bioinformatics analysis of key genes associated with EBV regulation of immune infiltration is still lacking. In the present study, the TCGA and GEO databases were recruited to analyse the association between EBV infection and the profile of immune infiltration in GC. The weighted gene co‐expression analysis (WGCNA) was applied to shed light on the key gene modules associated with EBV‐associated immune infiltration in GC. 204 GC tissues were used to analysed the expression of key hub genes by using the immunohistochemical method. Real‐time PCR was used to evaluate the association between the expression of EBV latent/lytic genes and key immune infiltration genes. Our results suggested that EBV infection changed the TME of GC mainly regulates the TIICs. The top three hub genes of blue (GBP1, IRF1, and LAP3) and brown (BIN2, ITGAL, and LILRB1) modules as representative genes were associated with EBV infection and GC immune infiltration. Furthermore, EBV‐encoded LMP1 expression is account for the overexpression of GBP1 and IRF1. EBV infection significantly changes the TME of GC, and the activation of key immune genes was more dependent on the invasiveness of the whole EBV virion instead of single EBV latent/lytic gene expression.
Early γGT and bilirubin levels as biomarkers for regeneration and outcomes in damaged bile ducts after liver transplantation
Authors: Junger Henrik , Mühlbauer Marco , Brennfleck Frank W. , Schurr Leonhard A. , Goetz Markus , Eggenhofer Elke , Kirchner Gabriele , Evert Katja , Fichtner‐Feigl Stefan , Geissler Edward K. , Schlitt Hans J. , Brunner Stefan M. 
Published: December 2022

AbstractBackgroundEarly patient and allograft survival after liver transplantation (LT) depend primarily on parenchymal function, but long‐term allograft success relies often on biliary‐tree function. We examined parameters related to cholangiocyte damage that predict poor long‐term LT outcomes after donation after brain death (DBD).MethodsSixty bile ducts (BD) were assessed by a BD damage‐score and divided into groups with “major” BD‐damage (n = 33) and “no relevant” damage (n = 27) during static cold storage. Patients with “major” BD damage were further investigated by measuring biliary excretion parameters in the first 14 days post‐LT (followed‐up for 60‐months).ResultsPatients who received LT showing “major” BD damage had significantly worse long‐term patient survival, versus grafts with “no relevant” damage (p = .03). When “major” BD damage developed, low bilirubin levels (p = .012) and high gamma‐glutamyl transferase (GGT)/bilirubin ratio (p = .0003) were evident in the early post‐LT phase (7–14 days) in patients who survived (> 60 months), compared to those who did not. “High risk” patients with bile duct damage and low GGT/bilirubin ratio had significantly shorter overall survival (p < .0001).ConclusionsOnce “major” BD damage occurs, a high GGT/bilirubin ratio in the early post‐operative phase is likely indicator of liver and cholangiocyte regeneration, and thus a harbinger of good overall outcomes. “Major” BD damage without markers of regeneration identifies LT patients that could benefit from future repair therapies.
Long‐term outcomes of kidney transplantation from deceased donors with terminal acute kidney injury: Single center experience and literature review
Authors: Garner Matthew , Jay Colleen L. , Sharda Berjesh , Webb Christopher , Farney Alan C. , Orlando Giuseppe , Rogers Jeffrey , Reeves‐Daniel Amber , Mena‐Gutierrez Alejandra , Sakhovskaya Natalia , Stratta Bobby , Stratta Robert J. 
Published: December 2022

AbstractIntroductionLong‐term outcomes of kidney transplantation from deceased donors (DDKTs) with terminal acute kidney injury (AKI) are not well defined.MethodsSingle center retrospective review of DDKTs from 1/31/07‐12/31/19. AKI kidneys were defined by a doubling of the donor's admission serum creatinine (SCr) level AND a terminal SCr ≥2.0 mg/dl.ResultsA total of 188 AKI DDKTs were performed, including 154 from brain‐dead standard criteria donors (SCD). Mean donor age was 36 years and mean Kidney Donor Profile Index was 50%; mean admission and terminal SCr levels were 1.3 and 3.1 mg/dl, respectively. With a mean follow‐up of 94 months (median 89 months), overall patient (both 71.3%) and graft survival (54% AKI vs. 57% non‐AKI) rates were comparable to concurrent DDKTs from brain‐dead non‐AKI SCDs (n = 769). Delayed graft function (DGF) was higher in AKI kidney recipients (47% vs. 20% non‐AKI DDKTs,p < .0001). DGF was associated with lower graft survival in recipients of both AKI and non‐AKI SCD kidneys but the impact was earlier and more pronounced in non‐AKI recipients.ConclusionsDespite having more than twice the incidence of DGF, kidneys from deceased donors with terminal AKI have long‐term outcomes comparable to non‐AKI SCD kidneys and represent a safe and effective method to expand the donor pool.
Intellectual functioning and adaptive behaviour in children with Dravet syndrome: A population‐based study
Authors: Reilly Colin , Bjurulf Björn , Hallböök Tove 
Published: December 2022

AbstractAimTo identify, on a population basis, the prevalence of intellectual disability in children with Dravet syndrome, profiles on a measure of adaptive behaviour, and factors associated with intellectual functioning and adaptive behaviour.MethodForty‐two out of 48 children with Dravet syndrome living in Sweden, born between 1st January 2000 and 31st December 2018, underwent assessment of intellectual functioning and adaptive behaviour. Factors associated with level of intellectual functioning and adaptive behaviour were analysed.ResultsEight‐six per cent (n = 36) of the children fulfilled DSM‐5 criteria for intellectual disability (29% [n = 12] mild intellectual disability, 24% [n = 10] moderate intellectual disability, 33% [n = 14] severe intellectual disability, 0% profound intellectual disability) and 93% (n = 39) had an adaptive behaviour composite more than two standard deviations below the mean. Communication was a significant weakness compared with daily living skills (p < 0.001; mean difference 95% confidence interval [CI] –8.193 to −4.092) and socialization (p = 0.001; mean difference 95% CI 6.511 to −1.775) on the Vineland Adaptive Behavior Scales, Second Edition. The only factors significantly associated with both decreased adaptive behaviour and presence of severe intellectual disability was the presence of increased autistic symptoms and younger age.InterpretationChildren with Dravet syndrome have a very high level of intellectual disability and almost all have significant deficits in adaptive behaviour. Greater deficits in adaptive behaviour and greater severity of intellectual disability are associated with the presence of increased autistic symptoms, highlighting the need for comprehensive neurodevelopmental assessment for all affected children.What this paper adds

Eighty‐six per cent (n = 36) of children with Dravet syndrome fulfilled criteria for intellectual disability.
Ninety‐three per cent (n = 39) of children with Dravet syndrome had significant deficits in adaptive behaviour.
Communication was a significant weakness on a measure of adaptive behaviour.
Increased autistic symptoms were associated with greater deficits in cognition/adaptive behaviour.
Older age and earlier status epilepticus were associated with decreased adaptive behaviour.
Analysis of Groundwater Overexploitation Based on Groundwater Regime Information
Authors: Li Huayao , Du Xinqiang , Lu Xiangqin , Fang Min 
Published: December 2022

AbstractAlthough groundwater overexploitation is a global problem, there are no unified standards for its identification and determination. To date, groundwater overexploitation has mainly been evaluated using the groundwater quantity balance and effect of groundwater exploitation on the environment. However, it is difficult to determine groundwater exploitation for an agricultural irrigation area owing to the lack of detailed environmental monitoring data. We used the experience of previous studies to introduce a novel identification model for groundwater overexploitation by relying on groundwater regime information and multi‐factor analysis. The model was applied to the Songhua River‐Naoli River area, Sanjiang Plain (China). In the demonstrated model, the study area was divided in the context of the risk of overexploitation into natural and non‐natural regime areas according to groundwater regime characteristics. The areas were identified by analyzing groundwater flow fields, cones of groundwater depression, and storage variation. The analysis demonstrated that the study area could be divided into high‐risk, medium‐risk, low‐risk, and non‐overexploitation areas with corresponding area ratios of 10.12%, 1.38%, 54.8%, and 33.7%. Moreover, the total amount of overexploited groundwater was estimated to be 30.41 × 108 m3 (average annual decrease = 1.69 × 108 m3). Overall, the proposed identification model was shown to be applicable to agricultural irrigation areas, thereby offering promising implications.
Effects of electrospraying parameters on deposition of La0.3Sr0.7Fe0.7Cr0.3O3−δ cathode layer on GDC
Authors: Akkurt Sedat , Sındıraç Can , Egesoy Tuğçe Özmen , Atıcı Gökçe , Erişman Elif , Erğen Emre , Büyükaksoy Aligül 
Published: December 2022

AbstractHigh performance in intermediate temperature solid oxide fuel cells requires improvements especially in the microstructure of the cathode layer. New cobalt‐free cathode materials are used because cobalt‐containing cathodes have higher thermal expansion coefficients, poor long‐term chemical stability, and lower mechanical stability. Recently cobalt‐free cathodes have been proposed to solve these issues by using deposition methods other than electrospray deposition (ESD). In this study, ESD method is used to develop a cobalt‐free cathode layer. The electrolyte layer is gadolinium‐doped ceria that is deposited with La0.3Sr0.7Fe0.7 Cr0.3O3−δ (LSFCr) prepared by 2‐butoxyethanol and ethylene glycol solvents as opposed to conventional solvents. Experimental ESD parameters are tested at different levels and combinations by applying statistical experimental design methods to optimize the microstructure. Coating deposited as such demonstrated higher electrochemical performance than similar electrodes fabricated by other methods.
Digital internal communication: An interplay of socio‐technical elements
Authors: Wuersch Lucia , Neher Alain , Peter Marc K. 
Published: December 2022

AbstractDigital transformation has become a research focus in recent years. Likewise, internal communication (IC) is one of the fastest‐growing specialisations in public relations and communication management. This research explores digital internal communication (DIC) at the nexus between digital transformation and IC. We provide an integrative review of the literature; our thematic analysis of selected journal articles and other scholarly texts is guided by the concept of organisations as socio‐technical systems. Furthermore, we create a template using NVivo software to organise the emerging themes and clusters following the logic of communication levels. This template allows us to explain the phenomenon of DIC in a socio‐technical organisational system and discuss how the emerging themes are interrelated, people‐focused, and linked to competency development and trust‐building. As a contribution to theory, we offer a conceptual model which illustrates the dynamics of DIC as an interplay of socio‐technical elements on three communication levels. This conceptual model can be further developed in scholarly discussions on DIC and by organisations reflecting on their IC use in a digital workplace environment.