bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doing good for society! How purchasing green technology stimulates consumers toward green behavior: A structural equation modeling–artificial neural network approach
Authors: Ashfaq Muhammad , Tandon Anushree , Zhang Qingyu , Jabeen Fauzia , Dhir Amandeep 
Published: July 2022

AbstractMany countries have recognized the urgent need to address environmental problems, such as air pollution, waste disposal, global warming, and natural resource depletion, through the application of green technology. ANT Forest is one such technological initiative that has gained academic attention for its potential to minimize adverse environmental impacts and promote sustainable green behavior by involving people in eco‐friendly activities. We built an integrated framework to understand users' continuance intention (CI) toward ANT Forest based on the expectation‐confirmation model (ECM) and the task–technology fit model (TTFM). Using structural equation modeling (SEM), we analyzed survey data from 353 ANT Forest users. We then included the SEM results as components of an artificial neural network (ANN) to understand users' CI toward ANT Forest. The results from the SEM analysis revealed a series of sequential associations: (a) green habit as an individual characteristic and perceived entertainment as a technology characteristic significantly affect perceived green task–technology fit (GTTF), (b) perceived GTTF strongly and positively influences confirmation and CI, (c) confirmation is positively associated with users' satisfaction and delight, (d) delight significantly impacts satisfaction, and (e) perceived usefulness (PU) and satisfaction are strong determinants of CI. An ANN analysis further confirmed these findings. The study discusses managerial implications along with future research directions.
Cytokine‐ and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy
Authors: Bhat Ajaz A. , Nisar Sabah , Singh Mayank , Ashraf Bazella , Masoodi Tariq , Prasad Chandra P. , Sharma Atul , Maacha Selma , Karedath Thasni , Hashem Sheema , Yasin Syed Besina , Bagga Puneet , Reddy Ravinder , Frennaux Michael P. , Uddin Shahab , Dhawan Punita , Haris Mohammad , Macha Muzafar A. 
Published: July 2022

AbstractColorectal cancer (CRC) is a predominant life‐threatening cancer, with liver and peritoneal metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor, nurtures a local inflammatory environment enriched with tumor cells, endothelial cells, immune cells, cancer‐associated fibroblasts, immunosuppressive cells, and secretory growth factors. The complex interactions of aberrantly expressed cytokines, chemokines, growth factors, and matrix‐remodeling enzymes promote CRC pathogenesis and evoke systemic responses that affect disease outcomes. Mounting evidence suggests that these cytokines and chemokines play a role in the progression of CRC through immunosuppression and modulation of the tumor microenvironment, which is partly achieved by the recruitment of immunosuppressive cells. These cells impart features such as cancer stem cell‐like properties, drug resistance, invasion, and formation of the premetastatic niche in distant organs, promoting metastasis and aggressive CRC growth. A deeper understanding of the cytokine‐ and chemokine‐mediated signaling networks that link tumor progression and metastasis will provide insights into the mechanistic details of disease aggressiveness and facilitate the development of novel therapeutics for CRC. Here, we summarized the current knowledge of cytokine‐ and chemokine‐mediated crosstalk in the inflammatory tumor microenvironment, which drives immunosuppression, resistance to therapeutics, and metastasis during CRC progression. We also outlined the potential of this crosstalk as a novel therapeutic target for CRC. The major cytokine/chemokine pathways involved in cancer immunotherapy are also discussed in this review.
Acid and Base Water Coexists in a Micro‐Structured Ionic Liquid and Catalyzes Organic Reactions in One‐Pot
Authors: Leyva‐Pérez Antonio , Bilanin Cristina , Bacic Matea , Greco Rossella 
Published: July 2022

AbstractThe most paradigmatic example of antagonist chemical species are protons and hydroxyls, and their coexistence in a liquid system is of high interest. Here we show that commercial ionic liquids stabilize microdroplets of water with pH<0 and pH>14, concomitantly and without any additive, and that this micro‐structured liquid medium catalyzes organic reactions in one‐pot.
The Surface Potential of Zero Charge Controls the Kinetics of Diazonium Salts Electropolymerization
Authors: Li Tiexin , Ciampi Simone , Darwish Nadim 
Published: July 2022

AbstractOne of the central fundamental properties of solid/liquid interfaces is the potential of zero charge (pzc), where no excess charge prevails at the electrode surface. Applying potential on either side of the pzc can control adsorption of molecules on surfaces and is paramount for any interfacial process. However, the impact of pzc on electrode processes has been only demonstrated for reactions involving the adsorption of inorganic ions and gases. Here, the direct relationship between the pzc and electropolymerization rate of a small organic molecule was reported. The electrochemical reduction of diazonium salts, which are the most commonly used molecules to form thin films of molecules on electrode surfaces, was tested. The kinetics of the surface reaction and the reduction potential in electrochemical measurements depended on the pzc of the surface following the order of gold>platinum>carbon>indium‐tin‐oxide>fluorine‐doped tin‐oxide>silicon hydride. The immediate consequence of this finding was that the concentration of the diazonium salt molecules became critical in defining the electrochemical reduction mechanism. At higher concentrations, the mechanism was pzc‐controlled adsorption‐dominated inner‐sphere electron transfer whereas at lower concentrations, diffusion‐based outer‐sphere electron transfer dominated.
Visualization of confusion matrices with network graphs
Authors: Gilbraith William E. , Celani Caelin P. , Booksh Karl S. 
Published: July 2022

AbstractThe use of network analysis as a means of visualizing the off‐diagonal (misclassified) elements of a confusion matrix is demonstrated, and the potential to use the network graphs as a guide for developing hierarchical classification models is presented. A very brief summary of graph theory is described. This is followed by an explanation and code with examples of how these networks can then be used for visualization of confusion matrices. The use of network graphs to provide insight into differing model performance is also addressed.
Limited phylogeographic and genetic connectivity in Acacia species of low stature in an arid landscape
Authors: Millar Melissa A. , Binks Rachel M. , Tapper Sarah‐Louise , Macdonald Bronwyn M. , McArthur Shelley L. , Hankinson Margaret , Coates David J. , van Leeuwen Stephen , Byrne Margaret 
Published: July 2022

AbstractWidespread plant species are expected to maintain genetic diversity and gene flow via pollen and seed dispersal. Stature is a key life history trait that affects seed and potentially pollen dispersal, with limited stature associated with limited dispersal and greater genetic differentiation. We sampled Hill’s tabletop wattle (Acacia hilliana) and curry wattle (Acacia spondylophylla), two co‐distributed, widespread, Acacia shrubs of low stature, across the arid Pilbara region of north‐western Australia. Using chloroplast sequence and nuclear microsatellite data we evaluated patterns of population genetic and phylogeographic diversity and structure, demographic signals, ratios of pollen to seed dispersal, evidence for historical refugia, and association between elevation and diversity. Results showed strong phylogeographic (chloroplast, GST = 0.831 and 0.898 for A. hilliana and A. spondylophylla, respectively) and contemporary (nuclear, FST = 0.260 and 0.349 for A. hilliana and A. spondylophylla, respectively) genetic structure in both species. This indicates limited genetic connectivity via seed and pollen dispersal associated with Acacia species of small stature compared to taller tree and shrub acacias across the Pilbara bioregion. This effect of stature on genetic structure is superimposed on moderate levels of genetic diversity that were expected based on widespread ranges (haplotype diversity h = 25 and 12; nuclear diversity He = 0.60 and 0.47 for A. hilliana and A. spondylophylla, respectively). Contemporary genetic structure was congruent at the greater landscape scale, especially in terms of strong genetic differentiation among geographically disjunct populations in less elevated areas. Measures of diversity and connectivity were associated with traits of greater geographic population proximity, population density, population size, and greater individual longevity, and some evidence for range expansion in A. hilliana. Results illustrate that low stature is associated with limited dispersal and greater patterns of genetic differentiation for congenerics in a common landscape and highlight the complex influence of taxon‐specific life history and ecological traits to seed and pollen dispersal.
Diet and prey selection of clouded leopards and tigers in Laos
Authors: Rasphone Akchousanh , Bousa Anita , Vongkhamheng Chantavy , Kamler Jan F. , Johnson Arlyne , Macdonald David W. 
Published: July 2022

AbstractIn Southeast Asia, conservation of ‘Vulnerable’ clouded leopards (Neofelis nebulosa) and ‘Endangered’ tigers (Panthera tigris) might depend on the management of their preferred prey because large felid populations are limited by the availability of suitable prey. However, the diet of clouded leopards has never been determined, so the preferred prey of this felid remains unknown. The diet of tigers in the region has been studied only from one protected‐area complex in western Thailand, but prey preferences were not determined. To better understand the primary and preferred prey of threatened felids, we used DNA‐confirmed scats and prey surveys to determine the diet and prey selection of clouded leopards and tigers in a hilly evergreen forest in northern Laos. For clouded leopards, the primary prey was wild pig (Sus scrofa; 33% biomass consumed), followed by greater hog badger (Arctonyx collaris; 28%), small rodents (15%), and mainland serow (Capricornis sumatraensis; 13%; hereafter, serow). For tigers, the primary prey was wild pig (44%), followed by serow (18%), sambar (Rusa unicolor; 12%), and Asiatic black bear (Ursus thibetanus; 10%). Compared to availability, serow was positively selected by both clouded leopards (D = 0.69) and tigers (0.61), whereas all other ungulate species were consumed in proportion to the availability or avoided. Our results indicate that clouded leopards are generalist predators with a wide prey spectrum. Nonetheless, mid‐sized ungulates (50–150 kg) comprised nearly half of their diet, and were the preferred prey, supporting a previous hypothesis that the enlarged gape and elongated canines of clouded leopards are adaptations for killing large prey. Because serow was the only ungulate preferred by both felids, we recommend that serow populations be monitored and managed to help conservation efforts for clouded leopards and tigers, at least in hilly evergreen forests of Southeast Asia.
Experimental and observational evidence of negative conspecific density dependence in temperate ectomycorrhizal trees
Authors: Jevon Fiona V. , De La Cruz Dayna , LaManna Joseph A. , Lang Ashley K. , Orwig David A. , Record Sydne , Kouba Paige V. , Ayres Matthew P. , Matthes Jaclyn Hatala 
Published: July 2022

AbstractConspecific negative density dependence (CNDD) promotes tree species diversity by reducing recruitment near conspecific adults due to biotic feedbacks from herbivores, pathogens, or competitors. While this process is well‐described in tropical forests, tests of temperate tree species range from strong positive to strong negative density dependence. To explain this, several studies have suggested that tree species traits may help predict the strength and direction of density dependence: for example, ectomycorrhizal‐associated tree species typically exhibit either positive or weaker negative conspecific density dependence. More generally, the strength of density dependence may be predictably related to other species‐specific ecological attributes such as shade tolerance, or the relative local abundance of a species. To test the strength of density dependence and whether it affects seedling community diversity in a temperate forest, we tracked the survival of seedlings of three ectomycorrhizal‐associated species experimentally planted beneath conspecific and heterospecific adults on the Prospect Hill tract of the Harvard Forest, in Massachusetts, USA. Experimental seedling survival was always lower under conspecific adults, which increased seedling community diversity in one of six treatments. We compared these results to evidence of CNDD from observed sapling survival patterns of 28 species over approximately 8 years in an adjacent 35‐ha forest plot. We tested whether species‐specific estimates of CNDD were associated with mycorrhizal association, shade tolerance, and local abundance. We found evidence of significant, negative conspecific density dependence (CNDD) in 23 of 28 species, and positive conspecific density dependence in two species. Contrary to our expectations, ectomycorrhizal‐associated species generally exhibited stronger (e.g., more negative) CNDD than arbuscular mycorrhizal‐associated species. CNDD was also stronger in more shade‐tolerant species but was not associated with local abundance. Conspecific adult trees often have a negative influence on seedling survival in temperate forests, particularly for tree species with certain traits. Here we found strong experimental and observational evidence that ectomycorrhizal‐associating species consistently exhibit CNDD. Moreover, similarities in the relative strength of density dependence from experiments and observations of sapling mortality suggest a mechanistic link between negative effects of conspecific adults on seedling and sapling survival and local tree species distributions.
Baseline clinical characteristics of heart failure patients with reduced ejection fraction enrolled in the BUDAPEST‐CRT Upgrade trial
Authors: Merkely Béla , Gellér László , Zima Endre , Osztheimer István , Molnár Levente , Földesi Csaba , Duray Gábor , Wranicz Jerzy K. , Németh Marianna , Goscinska‐Bis Kinga , Hatala Robert , Sághy László , Veres Boglárka , Schwertner Walter Richard , Fábián Alexandra , Fodor Eszter , Goldenberg Ilan , Kutyifa Valentina , Kovács Attila , Kosztin Annamária 
Published: July 2022

AbstractAimsThe BUDAPEST‐CRT Upgrade study is the first prospective, randomized, multicentre clinical trial investigating the outcomes after cardiac resynchronization therapy (CRT) upgrade in heart failure (HF) patients with intermittent or permanent right ventricular (RV) pacing with wide paced QRS. This report describes the baseline clinical characteristics of the enrolled patients and compares them to cohorts from previous milestone CRT studies.Methods and resultsThis international multicentre randomized controlled trial investigates 360 patients having a pacemaker (PM) or implantable cardioverter defibrillator (ICD) device for at least 6 months prior to enrolment, reduced left ventricular ejection fraction (LVEF ≤35%), HF symptoms (New York Heart Association [NYHA] functional class II–IVa), wide paced QRS (>150 ms), and ≥20% of RV pacing burden without having a native left bundle branch block. At enrolment, the mean age of the patients was 73 ± 8 years; 89% were male, 97% were in NYHA class II/III functional class, and 56% had atrial fibrillation. Enrolled patients predominantly had conventional PM devices, with a mean RV pacing burden of 86%. Thus, this is a patient cohort with advanced HF, low baseline LVEF (25 ± 7%), high N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) levels (2231 pg/ml [25th–75th percentile 1254–4309 pg/ml]), and frequent HF hospitalizations during the preceding 12 months (50%).ConclusionWhen compared with prior CRT trial cohorts, the BUDAPEST‐CRT Upgrade study includes older patients with a strong male predominance and a high burden of atrial fibrillation and other comorbidities. Moreover, this cohort represents an advanced HF population with low LVEF, high NT‐proBNP, and frequent previous HF events.Clinical Trial Registration: ClinicalTrials.gov NCT02270840.
Guideline‐directed medical therapy in patients undergoing transcatheter edge‐to‐edge repair for secondary mitral regurgitation
Authors: Higuchi Satoshi , Orban Mathias , Adamo Marianna , Giannini Cristina , Melica Bruno , Karam Nicole , Praz Fabien , Kalbacher Daniel , Koell Benedikt , Stolz Lukas , Braun Daniel , Näbauer Michael , Wild Mirjam , Doldi Philipp , Neuss Michael , Butter Christian , Kassar Mohammad , Ruf Tobias , Petrescu Aniela , Ludwig Sebastian , Pfister Roman , Iliadis Christos , Unterhuber Matthias , Sampaio Francisco , Ferreira Diogo , Thiele Holger , Baldus Stephan , von Bardeleben Ralph Stephan , Massberg Steffen , Windecker Stephan , Lurz Philipp , Petronio Anna Sonia , Lindenfeld JoAnn , Abraham William T. , Metra Marco , Hausleiter Jörg ,   EuroSMR Investigators
Published: July 2022

AimsGuideline‐directed medical therapy (GDMT), based on the combination of beta‐blockers (BB), renin–angiotensin system inhibitors (RASI), and mineralocorticoid receptor antagonists (MRA), is known to have a major impact on the outcome of patients with heart failure with reduced ejection fraction (HFrEF). Although GDMT is recommended prior to mitral valve transcatheter edge‐to‐edge repair (M‐TEER), not all patients tolerate it. We studied the association of GDMT prescription with survival in HFrEF patients undergoing M‐TEER for secondary mitral regurgitation (SMR).Methods and resultsEuroSMR, a European multicentre registry, included SMR patients with left ventricular ejection fraction <50%. The outcome was 2‐year all‐cause mortality. Of 1344 patients, BB, RASI, and MRA were prescribed in 1169 (87%), 1012 (75%), and 765 (57%) patients at the time of M‐TEER, respectively. Triple GDMT prescription was associated with a lower 2‐year all‐cause mortality compared to non‐triple GDMT (hazard ratio [HR] 0.74; 95% confidence interval [CI] 0.60–0.91). The association persisted in patients with glomerular filtration rate <30 ml/min, ischaemic aetiology, or right ventricular dysfunction. Further, a positive impact of triple GDMT prescription on survival was observed in patients with residual mitral regurgitation of ≥2+ (HR 0.62; 95% CI 0.44–0.86), but not in patients with residual mitral regurgitation of ≤1+ (HR 0.83; 95% CI 0.64–1.08).ConclusionTriple GDMT prescription is associated with higher 2‐year survival after M‐TEER in HFrEF patients with SMR. This association was consistent also in patients with major comorbidities or non‐optimal results after M‐TEER.
Violence against health care workers in the workplace in Mozambique – An unrecognised managerial priority
Authors: Patrício Sérgio Roques , Ferrinho Paulo , Sidat Mohsin 
Published: July 2022

AbstractIntroductionRecognition of the relevance of violence against health workers in their work place has been growing around the world. In Mozambique, workplace violence in the health sector needs better documentation. Therefore, this article is part of a study that describes the typology and the perceived impact of violence against health care workers in their workplace at the Lichinga Provincial Hospital and at the Health Centre of the City of Lichinga in 2019.MethodThis was an observational, descriptive, cross‐sectional study. The study was carried out in a simple random sample of health workers victims of violence at the Provincial Hospital and the Health Centre of the City of Lichinga, in the Province of Niassa in northern Mozambique. The questionnaire applied was adapted from the original developed by the International Labour Organization, the International Council of Nurse, the World Health Organization and Public Services International and applied in Maputo, Mozambique during 2002. Statistical analysis was carried out with Statistical Package for the Social Sciences 20.0 and WinPepi 11.65.ResultsTwo hundred and 60 healthcare workers (HCW) were selected to participate, 180 agreed, 145 had inclusion criteria and five gave up participating in the study during the consent procedure. Thus, a total of 140 HCW answered the questionnaire. Predominant types of violence were: verbal threat/aggression 34% (n = 62/180); moral pressure/bullying/mobbing 30% (n = 54/180); ethnic discrimination 9% (n = 16/180); against personal property 6% (n = 10/180); physical 4% (n = 8/180); sexual harassment 4% (n = 8/180). One hundred and 37 victims reported 154 episodes of violence, where 7% (n = 13/180) reported more than one type of violence. Most victims reported no reaction (55%, n = 76/137) and few said that they confronted the offender (16%, n = 22/137, particularly victims of sexual harassment, 38%, n = 3/8). Most HCW reported non‐existence (39%, n = 54/137) or unawareness (32%, n = 44/137) of procedures to report violence within the Institution. Most (80%, n = 33/41) of those knowing about the procedures, knew how to use them. More than half (55%; n = 76/137) of HCW said that they were discouraged to report acts of violence.ConclusionsLike for previous studies in Mozambique and elsewhere in Africa, the study confirms: a relatively high prevalence, a reluctance to talk about the issue and unawareness about procedures on how to report incidents. The findings reconfirm the necessity for the development and implementation of procedures to address violence incidents towards HCW, to develop support services for victims of health workplace violence. Like elsewhere in Africa, successive health workforce plans in Mozambique have failed to address this issue.
Serial multiple mediation of treatment adherence and disease activity in the relationship between continuity of care and health outcomes among rheumatoid arthritis patients
Authors: İlgün Gülnur , Şahin Bayram 
Published: July 2022

AbstractObjectiveTo evaluate the effect of continuity of care on health outcomes (quality of life and functionality) in patients with rheumatoid arthritis and to reveal whether treatment adherence and disease activity have a serial multiple mediator role on this relationship.MethodsThe study was cross‐sectional on 440 rheumatoid arthritis patients who applied to a university hospital rheumatology outpatient clinic. Research data were obtained from both the questionnaire method, which is the primary data source, and the patient files, which are the secondary data source. Process analysis was used in the analysis of the data.ResultsIt was found that the continuity of care has a direct effect on the quality of life and the functionality. In addition, it is seen that treatment adherence has a single partial mediator role on the relationship between continuity of care and quality of life; It has been determined that treatment adherence and disease activity have both partial single mediation and serial multiple mediation roles on the relationship between continuity of care and functionality.ConclusionIt is thought that these findings will provide clinicians with important data and information in the management of rheumatoid arthritis.