bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral 11β-HSD1 inhibitor AZD4017 improves wound healing and skin integrity in adults with type 2 diabetes mellitus: a pilot randomized controlled trial
Authors: Ajjan R A , Hensor E M A , Del Galdo F , Shams K , Abbas A , Fairclough R J , Webber L , Pegg L , Freeman A , Taylor A E , Arlt W , Morgan A W , Tahrani A A , Stewart P M , Russell D A , Tiganescu A 
Published: February 2022

Background
Chronic wounds (e.g. diabetic foot ulcers) reduce the quality of life, yet treatments remain limited. Glucocorticoids (activated by the enzyme 11β-hydroxysteroid dehydrogenase type 1, 11β-HSD1) impair wound healing.

Objectives
Efficacy, safety, and feasibility of 11β-HSD1 inhibition for skin function and wound healing.

Design
Investigator-initiated, double-blind, randomized, placebo-controlled, parallel-group phase 2b pilot trial.

Methods
Single-center secondary care setting. Adults with type 2 diabetes mellitus without foot ulcers were administered 400 mg oral 11β-HSD1 inhibitor AZD4017 (n = 14) or placebo (n = 14) bi-daily for 35 days. Participants underwent 3-mm full-thickness punch skin biopsies at baseline and on day 28; wound healing was monitored after 2 and 7 days. Computer-generated 1:1 randomization was pharmacy-administered. Analysis was descriptive and focused on CI estimation. Of the 36 participants screened, 28 were randomized.

Results
Exploratory proof-of-concept efficacy analysis suggested AZD4017 did not inhibit 24-h ex vivoskin 11β-HSD1 activity (primary outcome; difference in percentage conversion per 24 h 1.1% (90% CI: −3.4 to 5.5) but reduced systemic 11β-HSD1 activity by 87% (69–104%). Wound diameter was 34% (7–63%) smaller with AZD4017 at day 2, and 48% (12–85%) smaller after repeat wounding at day 30. AZD4017 improved epidermal integrity but modestly impaired barrier function. Minimal adverse events were comparable to placebo. Recruitment rate, retention, and data completeness were 2.9/month, 27/28, and 95.3%, respectively.

Conclusion
A phase 2 trial is feasible, and preliminary proof-of-concept data suggests AZD4017 warrants further investigation in conditions of delayed healing, for example in diabetic foot ulcers.

Significance statement
Stress hormone activation by the enzyme 11β-HSD type 1 impairs skin function (e.g. integrity) and delays wound healing in animal models of diabetes, but effects in human skin were previously unknown. Skin function was evaluated in response to treatment with a 11β-HSD type 1 inhibitor (AZD4017), or placebo, in people with type 2 diabetes. Importantly, AZD4017 was safe and well tolerated. This first-in-human randomized, controlled, clinical trial found novel evidence that 11β-HSD type 1 regulates skin function in humans, including improved wound healing, epidermal integrity, and increased water loss. Results warrant further studies in conditions of impaired wound healing, for example, diabetic foot ulcers to evaluate 11β-HSD type 1 as a novel therapeutic target forchronic wounds.
External validation of AIBx, an artificial intelligence model for risk stratification, in thyroid nodules
Authors: Swan Kristine Z , Thomas Johnson , Nielsen Viveque E , Jespersen Marie Louise , Bonnema Steen J 
Published: February 2022

Background
Artificial intelligence algorithms could be used to risk-stratify thyroid nodules and may reduce the subjectivity of ultrasonography. One such algorithm is AIBx which has shown good performance. However, external validation is crucial prior to clinical implementation.

Materials and methods
Patients harboring thyroid nodules 1–4 cm in size, undergoing thyroid surgery from 2014 to 2016 in a single institution, were included. A histological diagnosis was obtained in all cases. Medullary thyroid cancer, metastasis from other cancers, thyroid lymphomas, and purely cystic nodules were excluded. Retrospectively, transverse ultrasound images of the nodules were analyzed by AIBx, and the results were compared with histopathology and Thyroid Imaging Reporting and Data System (TIRADS), calculated by experienced physicians.

Results
Out of 329 patients, 257 nodules from 209 individuals met the eligibility criteria. Fifty-one nodules (20%) were malignant. AIBx had a negative predictive value (NPV) of 89.2%. Sensitivity, specificity, and positive predictive values (PPV) were 78.4, 44.2, and 25.8%, respectively. Considering both TIRADS 4 and TIRADS 5 nodules as malignant lesions resulted in an NPV of 93.0%, while PPV and specificity were only 22.4 and 19.4%, respectively. By combining AIBx with TIRADS, no malignant nodules were overlooked.

Conclusion
When applied to ultrasound images obtained in a different setting than used for training, AIBx had comparable NPVs to TIRADS. AIBx performed even better when combined with TIRADS, thus reducing false negative assessments. These data support the concept of AIBx for thyroid nodules, and this tool may help less experienced operators by reducing the subjectivity inherent to thyroid ultrasound interpretation.
Утворення темних дисипативних солітонів у середовищах з нелокальним відгуком
Authors: Бугайчук С.А. 
Published: February 2022

Знайдено стаціонарні розв'язки у формі tanh-функції для розподілу амплітуди динамічної ґратки та для розподілу максимумівінтенсивності картини інтерференції при самодифракції двох хвиль у відбиваючій геометрії в середовищах з нелокальним нелінійним відгуком. Розв'язки для інтенсивностей взаємодіючих хвиль залежать від інтеграла під кривою розподілу амплітуди ґратки. Розподіл за формою tanh-функції зсувається вздовж координати поширення хвиль при зміні співвідношення інтенсивностей хвиль на вході у середовище. Динамічну задачу розв'язано чисельно для взаємодії двохгаусівських імпульсів. Показано, що залежно від часової затримки між вхідними імпульсами можна управляти формою вихідних імпульсів, створюючи у середовищі різні дисипативні солітони – розподіли амплітуди ґратки.
Efek Pemberitaan Televisi Tentang Percepatan Penanganan Covid-19 Terhadap Proteksi Kesehatan (Survei Pada Mahasiswa UIN Syarif Hidayatullah Jakarta)
Authors: Supendi Egih , Nurbaya Siti , Ridho Kholis 
Published: February 2022

Pandemi virus korona telah dijumpai di lebih dari 120 negara dan berita tersebut disiarkan di berbagai media. Penelitian ini bertujuan untuk mengetahui pengaruh pemberitaan tentang virus korona oleh televisi di Indonesia terhadap munculnya kecemasan dan upaya menjaga kesehatan.Teori yang digunakan dalam penelitian ini adalah teori kultivasi. Teori ini berasumsi televisi secara independen berkontribusi dalam membentuk konsepsi penontonnya dalam menilai realitas sosial. Metode penelitian yang digunakan survei kuantitatif dengan pendekatan eksplanatif. Populasi penelitian adalah mahasiswa Fakultas Dakwah dan Ilmu Komunikasi UIN Jakarta. Sampel penelitian ini diperoleh dengan teknik teknik accidental sampling dan diperoleh sebanyak 98 orang responden. Metode pengumpulan data menggunakan kuesioner. Teknik analisis data yang digunakan terdiri dari korelasi product moment, uji regresi linear sederhana, dan uji determinasi.Hasil penelitian diketahui bahwa berita virus korona oleh Gugus Tugas Percepatan Penanganan Covid-19 di televisi berpengaruh terhadap persepsi akan pentingnya proteksi kesehatan sebesar 21,2%. Sedangkan pengaruh berita virus korona terhadap kecemasan sebesar 24,6%. Dapat disimpulkan selain dampak pemberitaan terhadap kecemasan akibat pemberitaan lebih tinggi daripada proteksi kesehatan, adalah juga medium televisi masih cukup efektif mengubah pemahaman dan perilaku publik.
Development and validation of RP-HPLC method for quantification of trace levels of topical corticosteroids in ambiphilic cream
Authors: Ivković Branka , Crevar Milkica , Cvetanović Anka , Ubavkić Katarina , Marković Bojan 
Published: February 2022

AbstractCorticosteroids are anti-inflammatory and immunosuppressant drugs. Topical corticosteroids formulations (ointments, creams, gels) are used in the treatment of different types of dermatitis and urticaria. Considering their therapeutic and whitening effects, they are frequently used for counterfeiting of cosmetic products. Corticosteroids can cause different local and systemic side effects. HPLC method is often chosen for their analysis, because it is selective, sensitive, precise, simple and fast.The aim of this study was optimization and validation of RP-HPLC method with UV detection for determination of trace levels of corticosteroids in ambiphilic creams. This method is used for qualitative and quantitative analysis of evaluated corticosteroids.Mometasone furoate, hydrocortisone acetate, fluocinonide, fluocinolone acetonide, betamethasone, betamethasone dipropionate and triamcinolone acetonide were evaluated. Separation was performed on Inertsil® ODS-3V 250 × 4.6 mm, 5 μm chromatographic column. Mobile phase was mixture of acetonitrile and water 50:50 (v/v) with gradient elution and flow rate 1 mL min−1. Column temperature was held on 40 °C and UV detection was performed at 240 nm.Selectivity, linearity, accuracy, precision and limit of quantification (LOQ) were evaluated. Method is selective because ambiphilic cream base peaks and corticosteroids peaks were not overlapping. Linearity was confirmed since correlation coefficient was 1 for all compounds. Accuracy and precision were evaluated for hydrocortisone acetate and betamethasone dipropionate. Determined Recovery values were in range of 70–130%. Both RSD values (21.46% and 9.59%) were lower than 30%. Method is highly sensitive since LOQ concentrations were in ng mL−1 range.All evaluated parameters of validation were in accordance with regulatory requirements. Validated RP-HPLC method can be used for qualitative and quantitative analysis of selected corticosteroids in ambiphilic creams.
Pendapatan Petani Agroforestri d Kecamatan Pantan Cuaca Kabupaten Gayo Lues
Authors: Yani Reni Rafika , Moulana Ryan , Anhar Ashabul 
Published: February 2022

Abstrak. Kecamatan Pantan Cuaca merupakan salah satu kecamatan yang berada di Kabupaten Gayo Lues. Tata guna lahan di Kecamatan Pantan Cuaca umumnya dimanfaatkan oleh masyarakat untuk tanaman perkebunan (kopi), tanaman semusim, maupun perpaduan antara keduanya. Pola pertanian yang dikelola masyarakat memiliki beberapa tipe antara lain agroforestri kopi, agroforestri pinus dengan sereh wangi dan tanaman semusim. Tujuan penelitian ini untuk mengetahui pola agroforestri yang mempengaruhi pendapatan masyarakat. Analisis data dalam penelitian ini menggunakan teknik analisis deskriptif, data diperoleh dari hasil pengamatan di lapangan melalui wawancara dan kuisioner kemudian dianalisis secara kuantitatif yaitu untuk mengetahui dan menganalisis data yang terkumpul dari hasil kuisioner, wawancara, observasi dan studi pustaka.Hasil yang diperoleh dari penelitian ini adalah nilai produk agroforestri yang memberikan kontribusi terbesar terhadap pendapatan masyarakat adalah dari tanaman kopi dengan nilai ekonomi sebesar Rp. 69.525.176/tahun pendapatan responden dari pemanfaatan agroforestri sereh wangi mencapai Rp. 17.905.669/tahun, sementara pendapatan responden dari hasil pemanfaatan tanaman lainnya hanya sebesar Rp. 3730750/tahun. Dari data tersebut dapat diketahui bahwa pendapatan dari kegiatan pemanfaatan agroforestri memberikan hasil yang lebih besar dibandingkan dengan pendapatan dari pemanfaatan tanaman lainnya di luar produk agroforestri.Agroforestry Farmer income in Gayo Lues District’s Pantan CuacaAbstact. Pantan Cuaca sub district is one of the sub-districts in Gayo Lues Regency. Land use in Pantan Cuaca District is generally used by the community for plantation crops (coffee), annual crops, or a combination of the two. The pattern of agriculture managed by the community has several types including coffee agroforestry, pine agroforestry with fragrant lemongrass and annual crops. The purpose of this study was to determine agroforestry patterns that affect community income. Data analysis in this study uses descriptive analysis techniques, data obtained from observations in the field through interviews and questionnaires and then analyzed quantitatively, that is to find out and analyze the data collected from the results of questionnaires, interviews, observations and literature studies.The results obtained from this study are the value of agroforestry products that provide the largest contribution to community income is from coffee plants with an economic value of Rp 69.252.176/year income of respondents from the use of fragrant cereals reached Rp 17.905.669/year, while respondents’ income from the use of other plants is only Rp 3.730.750/year. From these data it can be seen that the income from the use of agroforestry activities gives greater result compared to income from other uses outside of agroforestry product.
Eksplorasi Bakteri Selulolitik pada Ekosistem Mangrove
Authors: Sukoco Djanang , Fikrinda Fikrinda , Hifnalisa Hifnalisa 
Published: February 2022

Abstrak. Bakteri selulolitik dapat dijumpai pada lingkungan seperti ekosistem hutan mangrove. Keberadaannya pada ekosistem mangrove sangat penting untuk dekomposisi serasah magrove tersebut. Penelitian ini bertujuan untuk mengetahui adanya bakteri selulolitik pada ekosistem hutan mangrove dan potensinya dalam mendegradasi selulosa secara semi kuantitatif. Metode penelitian ini meliputi pengambilan sampel tanah, isolasi bakteri selulolitik dan uji kemampuan mendegradasi selulosa. Isolasi bakteri dilakukan dengan metode cawan tuang dan pada medium Carboxy Methyl Celullose (CMC). Uji kemampuan degradasi oleh bakteri selulolitik dilakukan pada medium dengan sumber karbon CMC dan daun mangrove. Parameter pengamatannya mengukur aktivitas selulolitik secara semi kuantitatif dan karakterisasi bakteri selulolitik. Hasil penelitian ini menunjukkan bakteri selulolitik yang terdapat di ekosistem mangrove berkisar antara 1,1x104 SPK g-1 tanah sampai 40,9x104 SPK g-1 tanah. Populasi bakteri selulolitik rata-rata asal tanah mangrove bakau kurap18,16x104 SPK g-1, api-api 12,98x104 SPK g-1dan bakau minyak 4,94x104 SPK g-1. Bakteri selulolitik yang memiliki aktivitas selulolitik tertinggi pada medium dengan sumber karbon CMC adalah isolat RM2.1;RA5.4;AA4.4 dengan rasio zona bening berturut-turut 5,2;4,4;2,5 dan pada medium dengan sumber karbon daun mangrove adalah isolat RA4.8;AA2.1;RM1.1 dengan rasio zona bening berturut-turut 2,3;1,2; 1,2.Exploration of Cellulolytic Bacteria in the Mangrove EcosystemAbstract. Cellulolytic bacteria can be found in environments such as mangrove forest ecosystems. Its presence in the mangrove ecosystem is very important for the decomposition of the magrove litter. This study aims to determine the presence of cellulolytic bacteria in mangrove forest ecosystems and their potential in semi-quantitative cellulose degradation. This research method includes soil sampling, isolation of cellulolytic bacteria and testing the ability to degrade cellulose. Bacterial isolation was carried out by the pour cup method and on Carboxy Methyl Celullose (CMC) medium. The degradation ability test by cellulolytic bacteria was carried out on a medium with CMC carbon source and mangrove leaves. The observational parameters measure semi-quantitative cellulolytic activity and characterization of cellulolytic bacteria. The results of this study showed that cellulolytic bacteria in the mangrove ecosystem ranged from 1,1x104 SPK g-1 soil to 40,9x104 SPK g-1 soil. The average population of cellulolytic bacteria from mangrove mangrove soil was ringworm 18,16x104 SPK g-1, fires 12,98x104 SPK g-1 and mangrove oil 4,94x104 SPK g-1. Cellulolytic bacteria that have the highest cellulolytic activity on medium with CMC carbon sources are isolates RM2.1;RA5.4;AA4.4 with clear zone ratios of 5,2;4,4; 2,5 and on medium with carbon sources mangrove leaves were RM1.1;AA2.1;RA4.8 isolates with a clear zone ratio of 2,3;1,2; 1,2, respectively.
Pengaruh Pengaturan Panen Terhadap Volume Produksi Tandan Buah Segar (TBS) Kelapa Sawit di PT.Semadam
Authors: Meutia Fira , Kadir Irwan A. , Romano Romano 
Published: February 2022

Abstrak. Pada kegiatan pemanenan kelapa sawit perlu dilakukan pengaturan panen agar produksi yang dihasilkan memiliki kualitas maupun kuantitas yang baik pula. Penelitian ini bertujuan untuk melihat pengaruh pengaturan panen terhadap volume produksi tandan buah segar (TBS) kelapa sawit di PT.Semadam selama 5 tahun (2015-2019). Adapun tujuan khususnya yaitu melihat pengaruh rotasi panen, tahun tanam, interaksi antara tahun tanam dengan rotasi panen serta interaksi masa trek dengan rotasi panen terhadap volume produksi tandan buah segar (TBS) kelapa sawit di PT.Semadam. Penelitian ini menggunakan metode analisis Two Way Anova dan dilanjutkan dengan Uji Tukey. Hasil penelitian ini yaitu terdapat pengaruh yang signifikan pada variabel rotasi panen dan tahun tanam terhadap volume TBS. Pada interaksi tahun tanam dengan rotasi panen nilai signifikan hanya terdapat pada 2 tahun, dan 3 tahun lainnya tidak signifikan. Interaksi masa trek dengan rotasi panen didapatkan nilai yang signifikan pada 4 tahun produksi, sedangkan pada tahun produksi 2016 nilai yang didapatkan tidak signifikan. Nilai yang signifikan menandakan adanya pengaruh antar variabel yang diteliti. Kata Kunci : panen, kelapa sawit, rotasi panen, two way anova Abstrac. In the activities of harvesting oil palm, it is necessary to arrange harvesting so that the production produced has good quality and quantity. This study aims to look at the effect of harvest regulation on the production volume of fresh fruit bunches of oil palm at PT.Semadam for 5 years (2015-2019). The specific objective is to see the effect of crop rotation, planting year, the interaction between planting years with crop rotation, and the interaction of the track rotation with harvest rotation on the production volume of fresh fruit bunches of oil palm at PT.Semadam. This research uses the Two Way Anova analysis method and continued with the Tukey Test. The results of this study are that there is a significant influence on the variable rotation of harvest and planting year on the volume of fresh fruit bunches. In the interaction of planting years with crop rotations, significant values were only found at 2 years, and the other 3 years were not significant. The interaction period of the track with the rotation of the harvest obtained a significant value at 4 years of production, whereas in the year of production 2016 the value obtained was not significant. A significant value indicates the influence between the variables studied. Keywords : harvesting, palm oil, rotation of harvest, two way anova
Efektivitas Pemanfaatan Teknologi Informasi Berbasis E-Commerce Pada Usaha Mikro, Kecil, dan Menengah (UMKM) Produk Pangan Di Kota Banda Aceh
Authors: Kusuma Handhika , Hakim Lukman , Nugroho Agus 
Published: February 2022

Abstrak. Tujuan penelitian ini yaitu untuk mengetahui efektivitas pemanfaatan Teknologi Informasi berbasis e-commerce pada Usaha Mikro, Kecil, dan Menengah (UMKM) di Kota Banda Aceh. Hasil penelitian memberikan informasi secara umum indikator dukungan pemerintah dianggap masih rendah. Dianggap masih rendah karena progressnya masih sangat lambat terhadap pemanfaatan teknologi informasi berbasis e-commerce pada UMKM produk pangan di Kota Banda Aceh. Indikator infrastruktur dalam pemanfaatan Teknologi Informasi berbasis e-commerce dianggap sudah efektif. Dianggap sudah efektif dikarenakan sarana dan prasarana telah dirasakan dan dapat dimanfaatkan oleh pelaku UMKM. Indikator sumber daya manusia dalam pemanfaatan Teknologi Informasi berbasis e-commerce dianggap masih rendah. Hal tersebut terjadi karena masih banyak pelaku UMKM produk pangan yang tidak mengerti dan tidak memahami tentang pemanfaatan Teknologi Informasi yang canggih ini.Kata Kunci: Teknologi Informasi, E-commerce, Usaha Mikro, Kecil dan MenengahAbstract. The purpose of this study is to determine the effectiveness of the use of e-commerce-based Information Technology in Usaha Mikro, Kecil dan Menengah (UMKM) in the City of Banda Aceh. The results of the study provided in general information that indicators of government support were still considered low. It is considered still low because the progress is still very slow towards the use of information technology based on e-commerce in food product SMEs in the City of Banda Aceh. Infrastructure indicators in the use of Information Technology based on e-commerce are considered effective. It is considered to be effective because the facilities and infrastructure have been felt and can be utilized by SMEs. Indicators of human resources in the use of information technology based on e-commerce are still considered low. This happens because there are still many MSME food product actors who do not understand or do not understand about the use of this advanced information technology.Keywords: Information Technology, E-commerce, Usaha Mikro, Kecil dan Menengah
Strategi Pengembangan Ternak Sapi Potong di Kecamatan Ulee Kareng Kota Banda Aceh
Authors: Asyikin Syarabul , Fauzi Teuku , Romano Romano 
Published: February 2022

Abstrak. Ternak sapi ialah salah satu jenis ternak yang hasil produksinya dipergunakan oleh manusia untuk memenuhi kebutuhan hidupnya. Permintaan konsumen akan daging sapi di Provinsi Aceh terus meningkat, namun produksi daging sapi yang tersedia tidak mampu memenuhi permintaan tersebut. Kecamatan Ulee Kareng merupakan salah satu kecamatan yang memiliki banyak peternak sapi dan peternakan sapi di Kecamatan Ulee Kareng berpotensi untuk dikembangkan. Dalam upaya pengembangan suatu usaha, harus ditetapkannya strategi yang akan diterapkan terlebih dahulu dengan cara menganalisis faktor internal dan eksternal yang terdapat pada usaha tersebut. Jurnal ini bertujuan untuk mengetahui faktor internal dan eksternal yang mempengaruhi pengembangan ternak sapi potong di Kecamatan Ulee Kareng serta menentukan strategi yang dapat diterapkan dalam mengembangkan ternak sapi potong di Kecamatan Ulee Kareng. Populasi pada penelitian ini yaitu peternak sapi potong di Kecamatan Ulee Kareng. Jumlah sampel yang digunakan yaitu sebanyak 12 peternak sapi potong di Kecamatan Ulee Kareng. Penelitian ini diolah dengan menggunakan Analisis SWOT. Penelitian ini menunjukan bahwa faktor yang menjadi kekuatan terbesar adalah ketersediaan pakan serta sumber air yang cukup dan ketersediaan lahan, kelemahan terbesar adalah rendahnya jumlah modal yang dimiliki, peluang terbesar adalah tingginya permintaan pasar, dan ancaman terbesar adalah tinggginya tingkat persaingan pasar. Strategi agresif merupakan strategi yang tepat untuk diterapkan. The Development Strategy of Beef Cattle in Ulee Kareng Sub-District, Banda AcehAbstract. Cow is one type of livestock whose production is used by humans to meet their daily needs. Consumer demand for beef in Aceh Province continues to increase, but the production of available beef cannot meet this demand. Ulee Kareng District is one of the districts that has a lot of cattle ranchers and cattle ranching in Ulee Kareng District has the potential to be developed. In an effort to develop a business, a strategy must be determined that will be applied first by analyzing internal and external factors contained in the business. This journal aims to determine the internal and external factors that influence the development of beef cattle in Ulee Kareng District and determine strategies that can be applied in developing beef cattle in Ulee Kareng District. The population in this study were beef cattle breeders in Ulee Kareng District. The number of samples used were 12 beef cattle farmers in Ulee Kareng District. This research was processed using SWOT Analysis. This research shows that the factors that become the biggest strength are the availability of sufficient food and water sources and land availability, the biggest weakness is the low amount of capital owned, the biggest opportunity is the high market demand, and the biggest threat is the high level of market competition. Aggressive strategy is the right strategy to implement.