bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERANCANGAN INTERIOR OMAH BATIK SOLO DI SURAKARTA
Authors: Atha’Illah Ibnu Atha’Illah , Budiwiyanto Joko Budiwiyanto 
Published: March 2022

Batik, warisan budaya yang tetap dilestarikan dari generasi ke generasi Indonesia. Batik Indonesia diakui oleh UNESCO pada tanggal 2 Oktober 2009 dalam daftar Representative sebagai Budaya Tak-benda Warisan Manusia (Representative list of the Intangible Cultural Heritage of Humanity) karena kaya akan simbol dan filosofi kehidupan rakyat Indonesia. Sejarah batik di Solo bermula pada masa Kerajaan Pajang lebih dari 4 abad yang lalu. Memasuki abad XX, batik menjadi salah satu identitas perekonomian masyarakat Jawa dan hingga kini nilai komersil lebih unggul dari edukasi. Perihal perlunya penunjang sarana edukasi mengenai batik yang mencakup rekreasi dan apreseiasi melatar belakangi perlu adanya Perancangan Interior Omah Batik Solo di Surakarta. Penggunaan kata Omah dari judul mengacu pada arti fungsional rumah, yakni sebagai tempat istirahat atau hunian, pembinaan atau perawatan dan bersosialisasi. Objek yang digarap memfokuskan pada interior ruang informasi, museum, runaway hall dan showroom dengan gaya ekletik (indisch-jawa) dengan pendekatan batik solo terpilih. Kata kunci: batik, solo, indisch, jawa
PERANCANGAN INTERIOR AULA, RUANG TRANSIT, PERPUSTAKAAN DAN KANTOR MASJID AGUNG AL AQSHA KLATEN
Authors: Prakoso Lalang Madyo , Indarto Indarto Indarto 
Published: March 2022

Masjid Agung Al Aqsha adalah daya tarik wisatawan karena letaknnya di pinggir Jalan Raya Solo-Yogyakarta, maka perlu perancangan interior yang mencerminkan ciri khas Kabupaten Klaten yaitu mengusung tema Batik Bayat merupakan salah satu produk unggulan Kabupaten Klaten. Mengusung gaya postmodern, mencampurkan dua gaya yaitu modern dengan tradisional. Batik Bayat memiliki ciri khas yaitu menggunakan satu warna dan cenderung coklat tua atau hitam. Batik Bayat mempunyai motif khas yang tidak ada pada daerah industri batik lainnya. Motif batik khas Bayat antara lain latar putih, kambil secukil atau kopi pecah, dan remukan. Kata Kunci : Masjid, Klaten, Postmodern, Batik Bayat.
REVITALISASI INTERIOR ISTANA GEBANG SEBAGAI MUSEUM BUNG KARNO DI KOTA BLITAR
Authors: Prihartono Putra HenggarIdham Rizky , Budiwiyanto Joko 
Published: March 2022

ABSTRAK Revitalisasi interior Istana Gebang sebagai Museum Bung Karno di Kota Blitarbertujuan mewujudkandesain interior yang dapat memenuhi kebutuhan pengunjung untuk beraktivitasÂ yang bersifat edukasi dan rekreasi secara aman dan nyaman. Tema interior yang digunakan adalah Indis dengan sentuhan Blitar yang ditampilkan secara kekinian. Museum Bung Karno di Kota Blitar adalah bangunan yang berfungsi melayani masyarakat dan perkembangannya, terbuka untuk umum, yang bertugas mengumpulkan, melestarikan, meneliti, mengkomunikasikan, memamerkan bukti-bukti bendawi presiden pertama Indonesia yaitu Soekarno, untuk tujuan studi, pendidikan dan kesenangan. Aktifitas yang ada pada museum Bung Karno di Kota Blitar adalah sebagai wadah pusat informasi tentang Soekarno, pengungkapan sejarah Soekarno dari masa ke masa .Untukmencapaitujuanperlumenggunakanpendekatanfungsi, ergonomi, danestetis.Metodepengumpulan data meliputistudi literature, wawancara, danobservasi.Metodeanalisis yang digunakanadalahmetodeinteraktif.Sehinggahasilrevitalisasimeliputibeberaparuangyaituruang lobby, introduksi, pamer, perpustakaan, dan audiovisual.Â Kata kunci : Revitalisasi, Istana Gebang,Museum,Fasilitas, dan LokalitasBlitar.Â Â ABSTRACTÂ Revitalization interior Istana Gebang as Museum in Kota Blitar Bung Karno aim of building an interior design that can meet the needs of visitors to be active are education and recreation in a safe and comfortable. Interior theme used was Indis with a touch of Blitar shown in the present. Bung Karno Museum in Kota Blitar is a building that serves serve society and its development, open to the public, which is in charge of collecting, preserving, researching, communicating, showing evidence of material first president of Indonesia, Sukarno, for the purposes of study, education and enjoyment. Activities that exist in museums in Kota Blitar Bung Karno is a venue information center about Sukarno, Sukarno history disclosure from time to time .To achieve the goals need to use the approach function, ergonomics and aesthetic. Methods of data collection include literature studies, interviews, and observations. The analytical method used is the interactive method. So the result of revitalization include several space is space lobby, introduction, showrooms, libraries and audiovisual.Â Keywords: Revitalization, Istana Gebang, Museum, facilities, and Localities Blitar.
PERENCANAAN INTERIOR INDONESIAN CREATIVE CHARACTER CENTER DI BANDUNG
Authors: Fauzi Fiqy , Indarto Indarto 
Published: March 2022

ABSTRAKDesain karakter kreatif merupakan salah satu bentuk ilustrasi yang hadir dengan konsep manusia.Banyaknya media aplikasi desain karakter berpotensi untuk membangkitkan, memperkenalkan dan mempromosikan karakter asli Indonesia kepada masyarakat luas.Perencanaan Interior Indonesian Creative Character Centerdi Bandung akan dijadikan sebagai pusat pengembangan karakter kreatif Indonesia dengan sentuhan budaya lokal. Tema perencanaan yang akan diangkat yaitu tokoh superhero Garudaman. Rasa nasionalisme pada karakter Garudaman menjadi alasan utama pemilihan tema tersebut.Tema superhero Garudaman akan dipadukan dengan gaya interior postmodern. Kata kunci: Karakter kreatif, Interior, Garudaman, Postmodern Â ABSTRACTCreative character design is a form of illustration that comes with the concept of human. The number of media applications has the potential to generate a character design, introduce and promote the original character of Indonesia to the wider community. Indonesian Interior Planning Creative Character Center in Bandung will serve as a center of creative character development of Indonesia with a touch of local culture. Themes plan that will be raised is the superhero Garudaman. A sense of nationalism in the characters Garudaman the main reason for the selection of the theme. Garudaman superhero theme will be integrated with the postmodern interior style.Â Keywords: Creative character, Interior, Garudaman, Postmodern
PERAMALAN JUMLAH PENGUNJUNG WISATAWAN MANCANEGARA MENGGUNAKAN METODE FUZZY TIME SERIES DI JAWA TIMUR
Authors: Dhebys Suryani  , Rokhimatul Wakhidah  , Arif latifudin  
Published: March 2022

Definisi wisatawan mancanegara adalah setiap orang yang melakukan perjalanan ke suatu negara di luar negara tempat tinggalnya kurang dari satu tahun didorong oleh suatu tujuan utama yaitu (bisnis, berlibur, atau tujuan pribadi lainya). Kunjungan wisatawan mancangara ke Jawa Timur di tahun 2018 sejumlah 830.968 kunjungan bila dibandingan dengan tahun 2017 yang jumlahnya 690.509 kunjungan, terlihat ada pertumbuhan sekitar 20.34%. Dari jumlah 830.968 kunjungan tersebut yang datang melalu Bandara Internasional Juanda sejumlah 322.965 sedangkan sisanya sejumlah 508.003 kunjungan adalah mereka yang datang ke Jawa Timur melalui darat. Peningkatan kunjungan wisatawan mancanegara ke Jawa Timur harus diantisipasi dengan pembangunan fasilitas yang mendukung kemajuan pariwisata, pembangunan yang dilakukan harus sejalan dengan pertumbuhan kunjungan wisatawan mancanegara ke Jawa Timur. Untuk mengetahui pertumbuhan kunjungan wisatawan mancanegara pada periode berikutnya perlu dilakukan peramalan terhadap kunjungan wisatawan mancanegara ke Jawa Timur.
Peramalan yang dibuat pada penelitian ini menggunakan metode Fuzzy Time Series dengan data Januari 2014 – Desember 2018 sebagai data historis untuk meramalkan di periode selanjutnya. Peramalan akan menggunakan metode fuzzy time series menggunakan 60 data sampel diperoleh error sebesar 11,4% yang diukur menggunakan Mean Absolute Percentage Error (MAPE).
Hubungan Kejadian Stunting dengan Perkembangan Anak Usia 6-23 Bulan
Authors: Syahruddin Akmal Novrian , Ningsih Nining Ade , Menge Fransiska 
Published: March 2022

Stunting masih menjadi masalah kesehatan masyarakat yang serius di Indonesia yang berdampak tidak hanya pada pertumbuhan linear tetapi juga pada perkembangan anak. Penelitian ini bertujuan untuk mengetahui hubungan kejadian stunting dengan perkembangan anak usia 6-23 bulan di Wilayah Kerja Puskemas Taraweang Kecamatan Labakkang Kabupaten Pangkep. Penelitian ini merupakan kuantitatif dengan pendekatan cross sectional study. Sampel penelitian sebanyak 72 responden berusia 6-23 bulan yang ditentukan dengan metode proportional random sampling. Stunting diukur berdasarkan nilai Z-score Panjang Badan berdasarkan Umur (PB/U) kurang dari -2 SD dan pengukuran perkembangan menggunakan kuesioner pra skining perkembangan (KPSP). Data dianalisis secara univariat dan bivariat menggunakan uji Chi-Square. Hasil penelitian menunjukkan bahwa kejadian stunting sebesar 36,1%. Stunting lebih banyak pada laki-laki (38,5%) dan meningkat sesuai kategori pertambahan umur 6-11, 12-17 dan 18-23 bulan berturut turut 25.0%, 36,4% dan 46.2%. Perkembangan anak dalam kategori meragukan sebesar 40,3%. Berdasarkan analisis menunjukkan hubungan antara kejadian stunting dengan perkembangan anak dengan nilai p-value 0.012 (p<0,05). Kesimpulan dari penelitian ini adalah stunting berhubungan dengan hambatan perkembangan anak usia 6-23 bulan di wilayah kerja Puskesmas Taraweang, Kabupaten Pangkep
Proteomic Responses of Dark-Adapted Euglena gracilis and Bleached Mutant Against Light Stimuli
Authors: Chen Zhenfan , Chen Zixi , Zhu Jiayi , He Jiayi , Liu Qiong , Zhu Hui , Lei Anping , Wang Jiangxin 
Published: March 2022

Euglena gracilis (E. gracilis) has secondary endosymbiotic chloroplasts derived from ancient green algae. Its chloroplasts are easily lost under numerous conditions to become permanently bleached mutants. Green cells adapted in the dark contain undeveloped proplastids and they will develop into mature chloroplasts after 3 days of light exposure. Thus, E. gracilis is an ideal model species for a chloroplast development study. Previous studies about chloroplast development in E. gracilis focused on morphology and physiology, whereas few studies have addressed the regulatory processes induced by light in the proteome. In this study, the whole-genome proteome of dark-adapted E. gracilis (WT) and permanently ofloxacin-bleached mutant (B2) was compared under the light exposure after 0, 12, and 72 h. The results showed that the photosynthesis-related proteins were up-regulated over time in both WT and B2. The B2 strain, with losing functional chloroplasts, seemed to possess a complete photosynthetic function system. Both WT and B2 exhibited significant light responses with similar alternation patterns, suggesting the sensitive responses to light in proteomic levels. The main metabolic activities for the utilization of carbon and energy in WT were up-regulated, while the proteins with calcium ion binding, cell cycle, and non-photosynthetic carbon fixation were down-regulated in B2. This study confirmed light-induced chloroplast development in WT from dark, and also for the first time investigates the light responses of a bleached mutant B2, providing more information about the unknown functions of residual plastids in Euglena bleached mutants.
Lipid Analysis of Fracture Hematoma With MALDI-MSI: Specific Lipids are Associated to Bone Fracture Healing Over Time
Authors: Groven Rald V. M. , Nauta Sylvia P. , Gruisen Jane , Claes Britt S. R. , Greven Johannes , van Griensven Martijn , Poeze Martijn , Heeren Ron M. A. , Porta Siegel Tiffany , Cillero-Pastor Berta , Blokhuis Taco J. 
Published: March 2022

Background: Fracture healing is a complex process, involving cell-cell interactions, various cytokines, and growth factors. Although fracture treatment improved over the last decades, a substantial part of all fractures shows delayed or absent healing. The fracture hematoma (fxh) is known to have a relevant role in this process, while the exact mechanisms by which it influences fracture healing are poorly understood. To improve strategies in fracture treatment, regulatory pathways in fracture healing need to be investigated. Lipids are important molecules in cellular signaling, inflammation, and metabolism, as well as key structural components of the cell. Analysis of the lipid spectrum in fxh may therefore reflect important events during the early healing phase. This study aims to develop a protocol for the determination of lipid signals over time, and the identification of lipids that contribute to these signals, with matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) in fxh in healthy fracture healing.Methods: Twelve fxh samples (6 porcine; 6 human) were surgically removed, snap frozen, sectioned, washed, and analyzed using MALDI-MSI in positive and negative ion mode at different time points after fracture (porcine: 72 h; human samples: range 1–19 days). A tissue preparation protocol for lipid analysis in fxh has been developed with both porcine and human fxh. Data were analyzed through principal component- and linear discriminant analyses.Results: A protocol for the preparation of fxh sections was developed and optimized. Although hematoma is a heterogeneous tissue, the intra-variability within fxh was smaller than the inter-variability between fxh. Distinctive m/z values were detected that contributed to the separation of three different fxh age groups: early (1–3 days), middle (6–10 days), and late (12–19 days). Identification of the distinctive m/z values provided a panel of specific lipids that showed a time dependent expression within fxh.Conclusion: This study shows that MALDI-MSI is a suitable analytical tool for lipid analysis in fxh and that lipid patterns within fxh are time-dependent. These lipid patterns within fxh may serve as a future diagnostic tool. These findings warrant further research into fxh analysis using MALDI-MSI and its possible clinical implications in fracture treatment.
Ultrasensitive Immunosensor for Prostate-Specific Antigen Based on Enhanced Electrochemiluminescence by Vertically Ordered Mesoporous Silica-Nanochannel Film
Authors: Ma Kai , Zheng Yanyan , An Lizhe , Liu Jiyang 
Published: March 2022

Ultrasensitive and specific detection of prostate-specific antigen (PSA) in complex biological samples is crucial for early diagnosis and treatment of prostate-related diseases. Immunoassay with a simple sensing interface and ultrahigh sensitivity is highly desirable. Herein, a novel electroluminescence (ECL) immunosensing platform is demonstrated based on the equipment of vertically ordered mesoporous silica-nanochannel films (VMSFs) with PSA antibody, which is able to realize ultrasensitive detection of PSA in human serum. Through the electrochemically assisted self-assembly (EASA) method, the VMSF is easily grown on an indium tin oxide (ITO) electrode in a few seconds. Owing to a large surface area and the negatively charged surface, VMSF nanochannels display strong electrostatic attraction to the positively charged ECL luminophores (tris(2,2-bipyridyl) dichlororuthenium (II), (Ru(bpy)32+), leading to two orders-of-magnitude enhancement of ECL emission compared with that of the bare ITO electrode. The outer surface of the VMSF is functionalized with reactive epoxy groups, which further allows covalent attachment of PSA antibody (Ab) on the entry of nanochannels. As the combination of PSA with Ab decreases the ECL signal by hindering the mass transfer of ECL luminophores and coreactant, the developed immunosensor can achieve ultrasensitive detection of PSA ranging from 1 pg ml−1 to 100 ng ml−1 with a limit of detection (LOD) of 0.1 pg ml−1. Considering the antifouling ability of the VMSF, sensitive detection of PSA in human serum is also realized. The proposed nanochannel-based immunosensor may open up a new way for the facile development of the universal immunosensing platform for rapid and ultrasensitive detection of disease markers.
Association Between Extraversion Personality With the Blood Pressure Level in Adolescents
Authors: Liang Xiaohua , Hao Guang , Xiao Lun , Luo Shunqing , Zhang Guifang , Tang Xian , Qu Ping , Li Rina 
Published: March 2022

PurposeThe association between extraversion personality and high blood pressure (BP) has not been well-studied. This study aims to explore the association between extraversion personality and the BP level in a large sample of adolescents.MethodsAs an ongoing study, 5,246 children aged 6–9 years were recruited using a stratified cluster sampling method in 2014. The extraversion personality trait, assessed by the Eysenck personality questionnaire (EPQ, answered by adolescents) in 2019, was used in the main analysis. A total of 3,407 participants were eligible and included in this analysis.ResultsThe EPQ extraversion score was negatively associated with a systolic BP, a diastolic BP, and mean arterial pressure (MAP) in a univariate analysis. After adjusting for other covariates, high extraversion score was negatively associated with systolic BP (β = −0.026; 95% CI = −0.047, −0.004; p = 0.002). There was an interaction between regions and the extraversion score on systolic BP (Pinteraction = 0.037). The stratified analysis showed that, in rural areas, the extraversion score was negatively associated with systolic BP (β = −0.050; 95% CI = −0.081, −0.016; p = 0.004). However, we did find an association between the extraversion score and systolic BP in urban areas (β = 0.000; 95% CI = −0.028, 0.028; p = 0.996). Similar results were observed for the extraversion assessed by parents.ConclusionsWe observed that extraversion personality was negatively associated with high BP in adolescents, especially for those who were living in rural areas. Our results suggested that a comprehensive intervention should be implemented to promote psychological health in adolescents.
Plasma Big Endothelin-1 Levels and Long-Term Outcomes in Patients With Atrial Fibrillation and Acute Coronary Syndrome or Undergoing Percutaneous Coronary Intervention
Authors: Lyu Si-qi , Zhu Jun , Wang Juan , Wu Shuang , Zhang Han , Shao Xing-hui , Yang Yan-min 
Published: March 2022

BackgroundThis study aimed to evaluate the association between plasma big ET-1 levels and long-term outcomes in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI).MethodsA total of 930 patients were enrolled and followed up for a median duration of 2.3 years. According to the optimal cutoff of big ET-1 for predicting all-cause death, these patients were divided into two groups. The primary endpoints were all-cause death and net adverse clinical events (NACE). The secondary endpoints included cardiovascular death, major adverse cardiovascular events (MACE), BARC class ≥ 3 bleeding, and BARC class ≥ 2 bleeding. Cox regressions were performed to evaluate the association between big ET-1 and outcomes.ResultsBased on the optimal cutoff of 0.54 pmol/l, 309 patients (33.2%) had high big ET-1 levels at baseline. Compared to the low big ET-1 group, patients in the high big ET-1 group tended to have more comorbidities, impaired cardiac function, elevated inflammatory levels, and worse prognosis. Univariable and multivariable Cox regressions indicated that big ET-1 ≥ 0.54 pmol/l was associated with increased incidences of all-cause death [HR (95%CI):1.73 (1.10–2.71), p = 0.018], NACE [HR (95%CI):1.63 (1.23–2.16), p = 0.001], cardiovascular death [HR (95%CI):1.72 (1.01–2.92), p = 0.046], MACE [HR (95%CI):1.60 (1.19–2.16), p = 0.002], BARC class ≥ 3 [HR (95%CI):2.21 (1.16–4.22), p = 0.016], and BARC class ≥ 2 bleeding [HR (95%CI):1.91 (1.36–2.70), p &lt; 0.001]. Subgroup analysis indicated consistent relationships between the big ET-1 ≥ 0.54 pmol/l and the primary endpoints.ConclusionElevated plasma big ET-1 levels were independently associated with increased risk of all-cause death, NACE, cardiovascular death, MACE, BARC class ≥ 3 bleeding, and BARC class ≥ 2 bleeding in patients with AF and ACS or undergoing PCI.
A High Triglyceride-Glucose Index Value Is Associated With an Increased Risk of Carotid Plaque Burden in Subjects With Prediabetes and New-Onset Type 2 Diabetes: A Real-World Study
Authors: Jiang Zhen-zhen , Zhu Jian-bo , Shen Hua-liang , Zhao Shan-shan , Tang Yun-yi , Tang Shao-qi , Liu Xia-tian , Jiang Tian-an 
Published: March 2022

BackgroundThe triglyceride-glucose (TyG) index has been proposed as a convincing indicator of insulin resistance and has been found to be associated with atherosclerosis among diabetic patients. However, the relationship between the TyG index and arteriosclerosis in subjects with prediabetes and new-onset type 2 diabetes (T2D) remains uncertain. The purpose of this study was to assess the degree of carotid plaque burden in patients with prediabetes and new-onset T2D and to investigate the association between the TyG index and the degree of carotid plaque burden in this population.MethodsThis was a cross-sectional observational study that included 716 subjects aged 40–70 years old with prediabetes or new-onset T2D. Demographic, anthropometric, and laboratory measurements were collected. Participants underwent carotid arteriosclerosis evaluation by ultrasonography, and the degree of atherosclerosis was evaluated according to the carotid plaque burden. The TyG index was calculated.ResultsThe population was stratified into high or low TyG index groups according to the median TyG index value. Higher values were associated with a higher BMI and waist circumference as well as higher total cholesterol, triglyceride, low-density lipoprotein cholesterol, plasma glucose, glycated hemoglobin, fasting C-peptide, and C-reactive protein levels (P &lt; 0.001). The high TyG index group had a higher atherosclerotic plaque burden than the low TyG index group (P &lt; 0.001). Multiclassification logistic regression analysis showed that the TyG index was positively associated with a high plaque burden [odds ratio (OR): 16.706, 95% confidence interval (CI): 3.988–69.978, P = 0.000], while no association was found between the TyG index and a low/moderate plaque burden. This association remained consistent in the subgroup analysis. In multiple linear regression analysis, sex, age, and the TyG index were found to be independently associated with carotid plaque burden. For each unit increase in the TyG index, the risk of a high carotid plaque burden increased 1.595-fold.ConclusionA high TyG index was positively associated with a high carotid plaque burden in subjects with prediabetes and new-onset T2D. Clinicians should pay close attention to the TyG index to help these patients receive the greatest benefit from early intervention.