bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfusate Composition and Duration of Ex-Vivo Normothermic Perfusion in Kidney Transplantation: A Systematic Review
Authors: Fard Amir , Pearson Robert , Lathan Rashida , Mark Patrick B. , Clancy Marc J. 
Published: May 2022

Ex-vivo normothermic perfusion (EVNP) is an emerging strategy in kidney preservation that enables resuscitation and viability assessment under pseudo-physiological conditions prior to transplantation. The optimal perfusate composition and duration, however, remain undefined. A systematic literature search (Embase; Medline; Scopus; and BIOSIS Previews) was conducted. We identified 1,811 unique articles dating from January 1956 to July 2021, from which 24 studies were deemed eligible for qualitative analysis. The perfusate commonly used in clinical practice consisted of leukocyte-depleted, packed red blood cells suspended in Ringer’s lactate solution with Mannitol, dexamethasone, heparin, sodium bicarbonate and a specific nutrient solution supplemented with insulin, glucose, multivitamins and vasodilators. There is increasing support in preclinical studies for non-blood cell-based perfusates, including Steen solution, synthetic haem-based oxygen carriers and acellular perfusates with supraphysiological carbogen mixtures that support adequate oxygenation whilst also enabling gradual rewarming. Extended durations of perfusion (up to 24 h) were also feasible in animal models. Direct comparison between studies was not possible due to study heterogeneity. Current evidence demonstrates safety with the aforementioned widely used protocol, however, extracellular base solutions with adequate oxygenation, supplemented with nutrient and metabolic substrates, show promise by providing a suitable environment for prolonged preservation and resuscitation.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021231381, identifier PROSPERO 2021 CRD42021231381
Hyperammonemia After Lung Transplantation: Systematic Review and a Mini Case Series
Authors: Kamel Amir Y. , Emtiazjoo Amir M. , Adkins Lauren , Shahmohammadi Abbas , Alnuaimat Hassan , Pelaez Andres , Machuca Tiago , Pipkin Mauricio , Lee Hyun-wook , Weiner I. David , Chandrashekaran Satish 
Published: May 2022

Background: Hyperammonemia after lung transplantation (HALT) is a rare but serious complication with high mortality. This systematic review delineates possible etiologies of HALT and highlights successful strategies used to manage this fatal complication.Methods: Seven biomedical databases and grey literature sources were searched using keywords relevant to hyperammonemia and lung transplantation for publications between 1995 and 2020. Additionally, we retrospectively analyzed HALT cases managed at our institution between January 2016 and August 2018.Results: The systematic review resulted in 18 studies with 40 individual cases. The mean peak ammonia level was 769 μmol/L at a mean of 14.1 days post-transplant. The mortality due to HALT was 57.5%. In our cohort of 120 lung transplants performed, four cases of HALT were identified. The mean peak ammonia level was 180.5 μmol/L at a mean of 11 days after transplantation. HALT in all four patients was successfully treated using a multimodal approach with an overall mortality of 25%.Conclusion: The incidence of HALT (3.3%) in our institution is comparable to prior reports. Nonetheless, ammonia levels in our cohort were not as high as previously reported and peaked earlier. We attributed these significant differences to early recognition and prompt institution of multimodal treatment approach.
Survival After Lung Transplantation for Chronic Hypersensitivity Pneumonitis: Results From a Large International Cohort Study
Authors: Nosotti Mario , Leiva-Juarez Miguel , D’Ovidio Frank , Van Raemdonck Dirk , Ceulemans Laurens , Keshavjee Shaf , Rackauskas Mindaugas , Paladini Piero , Luzzi Luca , Casado Paula Moreno , Alvarez Antonio , Inci Ilhan , Ehrsam Jonas , Krueger Thorsten , Roth Andrey , Rea Federico , Schiavon Marco , Rosso Lorenzo 
Published: May 2022

Repeated exposure to antigens via inhalation is the primary cause of hypersensitivity pneumonitis, a form of interstitial pneumonia. The chronic form of hypersensitivity pneumonitis leads to progressive loss of respiratory function; lung transplantation is the only therapeutic option for chronically ill patients. The ESTS Lung Transplantation Working Group conducted a retrospective multicentred cohort study to increase the body of knowledge available on this rare indication for lung transplantation. Data were collected for every patient who underwent lung transplant for hypersensitivity pneumonitis in participating centres between December 1996 and October 2019. Primary outcome was overall survival; secondary outcome was freedom from chronic lung allograft dysfunction. A total of 114 patients were enrolled from 9 centres. Almost 90% of patients were diagnosed with hypersensitivity pneumonitis before transplantation, yet the antigen responsible for the infection was identified in only 25% of cases. Eighty per cent of the recipients received induction therapy. Survival at 1, 3, and 5 years was 85%, 75%, and 70%, respectively. 85% of the patients who survived 90 days after transplantation were free from chronic lung allograft dysfunction after 3 years. The given study presents a large cohort of HP patients who underwent lung transplants. Overall survival rate is higher in transplanted hypersensitivity pneumonitis patients than in those suffering from any other interstitial lung diseases. Hypersensitivity pneumonitis patients are good candidates for lung transplantation.
Perancangan Aplikasi E-Learning Berbasis WEB pada SMA Negeri 5 Batanghari
Authors: Ibnu Sani  , Ali  , Pareza Alam  , Asri Suryo  
Published: May 2022

e-learning is one of the learning media which supports the teaching and learning process by using the internet. Currently at SMA Negeri 5 Batanghari the teaching and learning process is carried out during the pandemic using social media such as whatsapp. There are limitations of the whatsapp application so that teaching and learning activities at the school do not go well, such as sending assignments that can carry out automatic assessments. Based on that, it is necessary to develop a web-based e-learning application with the aim of research to make it easier for teachers to send and process grades automatically. The method used in this research is on system development using the waterfall. While the method of data collection is done by interviewing, observing and reviewing the literature into related research. In this research, a web-based e-learning application was produced using the PHP programming language and the MySQL database. The views obtained in this e-learning application are teacher data, student data, grade data, assignment delivery, and reports for teachers in the progress of activities during teaching and learning at SMA Negeri 5 Batanghari.
Keywords: Design, Website, E-learning
THE ROLE OF THE BUSINESS GAME IN TEACHING PROFESSIONALLY ORIENTED COMMUNICATION IN A FOREIGN LANGUAGE
Authors: Идигова Ж. Р. , Бериева А. М. 
Published: May 2022

В статье рассмотрена роль деловой игры в обучении профессионально-ориентированному общению на иностранном языке. Данный вопрос обусловлен необходимостью не только в профессионально-ориентированном обучении иностранному языку, но и в формировании и развитии межкультурной компетенции у студентов с целью обеспечения их конкурентоспособности на современном рынке труда. Процессы глобализации межкультурной и поликультурной коммуникации вытесняют монокультурное общение. В ходе межкультурного общения каждая из сторон представляется полноправным представителем своей культуры, на каком бы языке не велась коммуникация. Распространены ситуации, когда оба коммуниканта используют иностранный для них язык в качестве средства общения. Межкультурный подход отличается соблюдением равенства культур в процессе обучения иностранному языку, т. е. соблюдением принципа «культурной эгалитарности». Показана роль деловой игры как эффективной формы обучения в формировании иноязычной коммуникативной компетенции.
The article examines the role of the business game in teaching professionally-oriented communication in a foreign language. This issue is caused by the need not only for professionally oriented foreign language teaching, but also in the formation and development of intercultural competence among students in order to ensure their competitiveness in the modern labor market. The processes of globalization of intercultural and multicultural communication displace monocultural communication. In the course of intercultural communication, each of the parties is represented as a full representative of their culture, in whatever language communication is conducted. Situations are common when both communicants use a foreign language for them as a means of communication. The intercultural approach is distinguished by the observance of the equality of cultures in the process of teaching a foreign language, i. e. compliance with the principle of “cultural egalitarianism”. The role of the business game as an effective form of learning in the formation of foreign language communicative competence is shown.
CORPORATE VENTURE CAPITAL FUNDS AS THE BASIS FOR DEVELOPING BREAKTHROUGH INNOVATIONS TO SUPPORT THE INNOVATIVE ACTIVITY OF THE ENTERPRISE
Authors: Тавбулатова З. К. , Магомаева Л. Р. , Сулумов И. О. 
Published: May 2022

Прорывные инновации играют важнейшую роль в преобразовании отраслей и формировании новых рынков. Однако процесс их создания значительно отличается от поддерживающей инновационной деятельности. Целью статьи является формулирование основных компонентов инновационной системы крупных предприятий, направленной на систематическую реализацию прорывных инноваций. В статье выделены различия и особенности создания прорывных инноваций малыми и крупными предприятиями, в отличие от организации инновационного процесса в крупных кампаниях. Установлено, что малые предприятия играют основную роль в разработке прорывных инноваций, причем их активность в этой области со временем увеличивается. Авторами сделаны выводы о том, что сетевой принцип взаимодействия, при котором каждая из структурных единиц является носителем определенных ключевых компетенций, оптимален для реализации прорывных проектов на современном этапе инновационного развития. Авторами предложены конкретизированные меры по адаптации данного принципа к деятельности корпоративных венчурных фондов. Указано, что именно эти меры служат базисом для построения корпоративной инновационной системы, направленной на прорывную инновационную деятельность.
Breakthrough innovations play a critical role in transforming industries and shaping new markets. However, the process of their creation is significantly different from the supporting innovation activities. The purpose of the article is to formulate the main components of the innovation system of large enterprises, aimed at the systematic implementation of breakthrough innovations. The article highlights the differences and features of the creation of breakthrough innovations by small and large enterprises in contrast to the traditional innovation process. It is established that small enterprises play a major role in the development of breakthrough innovations, and their activity in this area increases over time. The authors draw conclusions that the network principle of interaction, in which each of the structural units is a bearer of certain key competencies, is optimal for the implementation of breakthrough projects at the present stage of innovative development. The authors propose specific measures to adapt this principle to the activities of corporate venture capital funds. It is indicated that these measures serve as the basis for building a corporate innovation system aimed at breakthrough innovation activities.
MODERN CULTURAL AND CIVILIZATIONAL PROCESSES: THEORETICAL AND METHODOLOGICAL ANALYSIS
Authors: Акаев В. Х. , Исмаилова Л. М. 
Published: May 2022

Понятия «культура» и «цивилизация» в социальной философии находят разные интерпретации, но всегда они соотносятся с общей тенденцией социального, культурного развития общества. Архаичным смыслом понятия «культура», которое придано римлянами, является возделывание, обработка земли, когда слово «цивилизация» с французского языка переводится как воспитанный, гражданский, государственный, достойное поведение гражданина, достигшего высокого уровня социокультурного развития. Культурно-цивилизационные процессы как сочетание духовного, культурного развития общества и его аграрного, индустриального и информационно-технологического развития определяют бытие человека и человечества в целом. Цивилизация как социально-технологическое явление содержит в себе разные смыслы, она понимается как стадия (ступень, эпоха) развития человечества, приходящая на смену первобытному обществу, которое трансформировалось до его нынешнего состояния. Будучи социокультурным образованием, цивилизация - это полиэтничная целостность, длительное время формирующаяся на этапе социального развития, следуя за первобытнообщинным строем и преодолевая его. Культура и цивилизация в своей совокупности - это стадия развития социокультурной системы, когда творческие силы людей, социальных групп, народов расходуются, и вместо живого и непосредственного их проявления видны механические, часто отчужденные от внутреннего смысла социального бытия формы жизни и поведения людей.
The concepts of “culture” and “civilization” in social philosophy find different interpretations, but they always correlate with the general trend of the social and cultural development of society. The archaic meaning of the concept of “culture”, which was given by the Romans, is cultivation, cultivation of the land, when the word “civilization” is translated from French as a well-mannered, civil, state, worthy behavior of a citizen who has reached a high level of socio-cultural development. Cultural and civilizational processes as a combination of the spiritual, cultural development of society and its agrarian, industrial and information technology development determine the existence of man and mankind as a whole. Civilization as a socio-technological phenomenon contains different meanings, it is understood as a stage (stage, era) of human development, replacing the primitive society, which has been transformed to its current state. Being a socio-cultural formation, civilization is a multi-ethnic integrity, for a long time, formed at the stage of social development, following the primitive communal system and overcoming it. Culture and civilization in their totality is a stage in the development of a socio-cultural system, when the creative forces of people, social groups, peoples are spent and instead of their living and direct manifestation, mechanical forms of life and behavior of people are often alienated from the inner meaning of social existence.
TINGKAT KECEMASAN PADA PERAWAT RUANGAN ISOLASI COVID-19
Authors: Pitoy Frendy Fernando , Wuisang Metty , Limando Jonathan 
Published: May 2022

Abstrak
Tenaga kesehatan khususnya perawat merupakan komponen yang sangat penting dalam pemenuhan kebutuhan kesehatan pasien yang dirawat. Namun, dimasa pandemic covid-19 tenaga keperawatan akan merasa berbeda dikarenakan rentannya terpapar dengan virus covid-19 dan lebih mungkin akan mengalami kecemasan. Tujuan dari penelitian ini adalah untuk mengetahui tingkat kecemasan perawat ruangan isolasi covid-19 di RSUP Prof. R. D. Kandou Manado. Metode yang digunakan dalam penelitian ini adalah penelitian descriptive correlation dengan teknik total sampling dengan menggunakan 151 perawat yang bekerja di ruang isolasi covid-19. Hasil dari penelitian menunjukan bahwa sebagian besar tenaga keperawatan yang bekerja di ruang isolasi covid-19 tidak merasa cemas saat bekerja dengan nilai persentase mencapai 95%. Lebih lanjut data menunjukan bahwa tidak ada perbedaan yang signifikan tingkat kecemasan para perawat jika ditinjau dari jenis kelamin dengan nilai p = 0.175 > 0.05, terdapat perbedaan yang signifikan saat ditinjau dari ruang perawatan dengan nilai p = 0.003 < 0.05. Dapat disimpulkan bahwa perawat yang bekerja di ruang perawatan isolasi covid-19 RSUP Prof. R. D. Kandou Manado tidak merasakan kecemasan baik laki-laki maupun perempuan, tapi terdapat perbedaan tingkat kecemasan perawat antara ruang perawatan. Berdasarkan hasil tersebut, dapat direkomendasikan bagi institusi rumah sakit untuk memperhatikan kariawan yang bekerja di ruangan isolasi covid-19 khususnya diruangan Anggrek 1 dan Irina F.
Kata kunci : Covid-19, Tingkat kecemasan, Perawat ruang isolasi

Abstrac
Health workers, especially nurses, are very important components in improving the health of patients. However, during the COVID-19 pandemic, nursing staff will experience the difference of being exposed to the Covid-19 virus and are more likely to experience anxiety. The purpose of this study was to determine the anxiety level of nurses in the Covid-19 isolation room at Prof. RSUP. R.D. Kandou Manado. A method of descriptive correlation was utilized in this study with 151 nurses working in covid-19 isolation room which are selected using total sampling technique. The results of the study show that most of the nursing staff who work in the COVID-19 isolation room did not feel anxious while working with a percentage value of 95%. Furthermore, the result shows that there is no significant difference in the level of anxiety of the nurses when sex is considered with a p value of 0.175 > 0.05, and there is a significant difference when nursing ward was considered with a p value 0.003 < 0.05. Conclusion that the nurses who work in the Covid-19 isolation room at Prof. R. D. Kandou Manado did not experience any anxiety either male or female, but there is a difference in the level of anxiety of nurses when the nursing word is considered. The recommendation for hospital to pay attention for the employees who work in the Covid-19 isolation room, especially in the Anggrek 1 and Irina F.

Keywords: Covid-19, Anxiety Level, Nursing Isolation Room
PERBANDINGAN KUALITAS HIDUP PASIEN GAGAL GINJAL KRONIK DENGAN KOMORBID FAKTOR DIABETES MELLITUS DAN HIPERTENSI PADA PASIEN YANG MENJALANI HEMODIALISA
Authors: Rantepadang Andreas 
Published: May 2022

Abstrak
Hipertensi dan Diabetes mellitus (DM) merupakan faktor komorbid yang berperan penting dalam peningkatan penderita Gagal ginjal kronik yang mengharuskan menjalani hemodialisa supaya kualitas hidup pasien Gagal ginjal kronik dapat dipertahankan atau ditingkatkan. Tujuan penelitian ini adalah menganalisa perbandingan kualitas hidup pasien gagal ginjal kronik dengan komorbid faktor Diabetes Melitus dan Hipertensi pada pasien yang menjalani hemodialisa. Metode penelitian observasional analitik dengan desain penelitian cross sectional, Populasi pada peneilitian ini adalah penderita Gagal ginjal kronik yang menjalani Hemodialisa di RSA Manado, penentuan sampel purposive sampling terdapat 43 sampel yang memenuhi kriteria penelitian, 23 responden komorbid Hipertensi dan 20 komorbid DM. Hasil penelitian didapatkan rata-rata kualitas hidup pada pasien Hemodialisa dengan komorbid DM 55.25 sedangkan pada pasien hemodialisa dengan komorbid hipertensi lebih tinggi yaitu 57.69 untuk hasil uji independent t test didapatkan nilai p-value 0.479 >0.05 yang menunjukkan tidak ada perbedaan yang signifikan kualitas hidup pada pasien Gagal ginjal Kronik dengan komorbid DM dan hipertensi. Kesimpulan: secara rata-rata kualitas hidup pasien Gagal ginjal kronik dengan komorbid Hipertensi lebih baik dibandingkan dengan komorbid DM tetapi secara statistik tidak signifikan. Saran: Diharapkan untuk penelitian selanjutnya untuk menambah jumlah sampel dan sampel yang seimbang antara kedua kelompok.
HUBUNGAN ASUPAN ENERGI DAN AKTIVITAS FISIK DENGAN DAYA TAHAN OTOT PADA ANAK
Authors: Saluy Priscillia Merylin , Supatman Ernando , Purnawinadi I Gede 
Published: May 2022

Daya tahan otot merupakan kemampuan daya tahan seseorang untuk melawan kelelahan seperti lari, sit-up dan asupan energi serta aktivitas fisik merupakan indicator meningkatkan daya tahan otot. Sumber energi pada manusia dalam bentuk karbohidrat, lemak dan protein, tanpa asupan energi yang cukup setiap harinya, anak akan mengalami kelelahan mental serta fisik dan aktivitas fisik menyebabkan tubuh kelelahan atau kehabisan tenaga dan olahraga adalah salah satu aktivitas fisik. Tujuan penelitian ini adalah mengetahui apakah ada hubungan antara asupan energi dan aktivitas fisik dengan daya tahan otot pada anak kelas 4 dan 5 di SDN 2 Airmadidi. Penelitian ini menggunakan metode cross sectional dengan rumus pearson correlation. Pengumpulan data dilakukan pada bulan Februari 2017. Hasil penelitian menunjukkan asupan energi anak-anak normal yaitu 100,97%, klasifikasi aktivitas anak-anak sedang dan daya tahan otot lari 11.74 kali dan sit-up 21.28 kali. Hasil uji statistik menunjukkan ada hubungan asupan energi dengan daya tahan otot (sit-up)0.039<0.05 dengan kuat hubungan sedang, tidak ada hubungan asupan energi dengan daya tahan otot (lari) 0.890>0.05, tidak ada hubungan aktivitas fisik dengan daya tahan otot (sit-up) 0.084>0.05, dan tidak ada hubungan aktivitas fisik dengan daya tahan otot (lari) 0.107>0.05. Rekomendasi penelitian ini untuk pemenuhan asupan energi dan aktivitas fisik dapat diterapkan pada anak dalam masa pertumbuhan usia 8-12 tahun.

Kata kunci : Asupan Energi, Aktivitas Fisik, Daya Tahan Otot.
A Multiplanet System’s Sole Super-puff: Exploring Allowable Physical Parameters for the Cold Super-puff HIP 41378 f
Authors: Belkovski Michelle , Becker Juliette , Howe Alex , Malsky Isaac , Batygin Konstantin 
Published: May 2022

Abstract
The census of known exoplanets exhibits a variety of physical parameters, including densities that are measured to span the range from less dense than Styrofoam to more dense than iron. These densities represent a large diversity of interior structures. Despite this staggering diversity, recent analyses have shown that the densities of planets that orbit a common star exhibit remarkable uniformity. A fascinating exception to this is the system HIP 41378 (also known as K2-93), which contains a super-puff planet, HIP 41378 f, as well as several planets with more typical bulk densities. The range of densities in this system begs the question of what physical processes are responsible for the disparate planetary structures in this system. In this paper, we consider how the densities of the planets in the HIP 41378 system would have changed over time as the host star evolved and the planets’ atmospheres were subsequently affected by the evolving insolation level. We also present a range of allowable core masses for HIP 41378 f based on the measured planet parameters, and we comment on the feasibility of the proposed existence of planetary rings around HIP 41378 f as an explanation for its current low density.