bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mammary Tumor Growth and Proliferation Are Dependent on Growth Hormone in Female SV40 C3(1) T-Antigen Mice
Authors: Unterberger Christopher J , McGregor Stephanie M , Kopchick John J , Swanson Steven M , Marker Paul C 
Published: October 2022

Abstract
Female SV40 C3(1) T-antigen (C3(1)/TAg) transgenic mice develop mammary tumors that are molecularly similar to human basal-like breast cancers with 100% incidence at 16 weeks of age. To determine the requirement for growth hormone (GH) signaling in these tumors, genetic crosses were used to create cohorts of female mice that were homozygous for a floxed growth hormone receptor (Ghr) gene and carried one copy each of the Rosa-Cre-ERT2 transgene and the C3(1)/TAg transgene (Ghrflox/flox; Rosa-Cre-ERT2; C3(1)/TAg+/0 mice). When the largest mammary tumor reached 200 mm3, mice were treated with tamoxifen to delete Ghr or with vehicle as a control. An additional group of Ghrflox/flox; C3(1)/TAg+/0 mice were also treated with tamoxifen when the largest mammary tumor reached 200 mm3 as a control for the effects of tamoxifen. After 3 weeks, tumors in mice in which Ghr was deleted began to shrink while vehicle and tamoxifen treatment control mouse tumors continued to grow. Pathological analysis of tumors revealed similar growth patterns and varying levels of necrosis throughout all groups. A decrease in cancer cell proliferation in Ghr-/- tumors relative to controls was observed as measured by Ki67 immunohistochemistry labeling index. These data suggest that even established C3(1)/TAg mammary tumors are dependent on the GH/IGF-1 axis.
Self-organizing in vitro mouse neural tube organoids mimic embryonic development
Authors: Park JiSoo , Hsiung Hao-An , Khven Irina , La Manno Gioele , Lutolf Matthias P. 
Published: October 2022

ABSTRACT
The embryonic neural tube is the origin of the entire adult nervous system, and disturbances in its development cause life-threatening birth defects. However, the study of mammalian neural tube development is limited by the lack of physiologically realistic three-dimensional (3D) in vitro models. Here, we report a self-organizing 3D neural tube organoid model derived from single mouse embryonic stem cells that exhibits an in vivo-like tissue architecture, cell type composition and anterior-posterior (AP) patterning. Moreover, maturation of the neural tube organoids showed the emergence of multipotent neural crest cells and mature neurons. Single-cell transcriptome analyses revealed the sequence of transcriptional events in the emergence of neural crest cells and neural differentiation. Thanks to the accessibility of this model, phagocytosis of migrating neural crest cells could be observed in real time for the first time in a mammalian model. We thus introduce a tractable in vitro model to study some of the key morphogenetic and cell type derivation events during early neural development.
Endurance training does not affect maximum exertion/distance capacity in Anolis carolinensis lizards
Authors: Sorlin Mahaut V. , Marks Jamie R. , Lailvaux Simon P. 
Published: October 2022

ABSTRACT
Locomotor performance abilities are key predictors of survival and reproductive success in animals and understanding how selection targets them can provide insights into how morphology and physiology relate to fitness. But despite the large body of work on performance traits, along with well-established protocols to measure them, performance can be challenging to measure. Endurance, for instance, is commonly measured by recording how long an animal can run at a set pace until exhaustion, which is time consuming and requires dedicated equipment. Consequently, exertion or distance capacity, measured as distance run until exhaustion when chased, is often used as a proxy for endurance, but the relationship between these two metrics has never been assessed even though they likely rely on different underlying physiological mechanisms. We tested experimentally for a relationship between endurance and exertion by training green anole lizards for sprinting and endurance and measuring whether exertion capacity responds to either type of training. Prior to training and across treatments, males displayed a mean (±s.d.) exertion capacity of 14.08±0.29 m and females 12.03±3.52 m; after training, this was 14.78±3.57 m and 12.19±2.21 m, respectively. We found that exertion capacity was unaffected by either type of training in green anoles. We also show that a positive relationship between endurance and exertion capacity pre-training exists only in females and that this relationship is inconsistent among studies. Exertion should be studied as a locomotor trait in its own right and not as a proxy for endurance.
The role of ecdysteroid in the regulation of ovarian growth and oocyte maturation in Rhodnius prolixus, a vector of Chagas disease
Authors: Benrabaa Samiha A. M. , Orchard Ian , Lange Angela B. 
Published: October 2022

ABSTRACT
Rhodnius prolixus is a blood-gorging insect that is medically important since it transmits Chagas disease via feces and urine that contain the parasite Trypanosoma cruzi. In adult females, ecdysteroid hormone (20-hydroxyecdysone, 20E) is involved in the growth of the ovary and development of eggs post-blood meal (PBM). Halloween genes are essential for ecdysteroid synthesis since they code for cytochrome P450 enzymes in the ecdysteroidogenic pathway. The ecdysone receptor (EcR/USP) binds 20E, resulting in activation of ecdysone-responsive genes. We have identified and characterized the Halloween genes, and the non-Halloween gene, neverland, in the R. prolixus ovary using transcriptomic data. We used BLAST to compare transcriptome sequences with other arthropod sequences to identify similar transcripts. Our results indicate that the Halloween genes, neverland and ecdysone receptor transcripts are present in the ovaries of R. prolixus. We have quantified, by qPCR, Halloween gene transcript expression in the ovary following a blood meal. Most of the Halloween genes are upregulated during the first 3 days PBM. Knockdown of EcR, USP and shade transcripts, using RNA interference, results in a significant reduction in the number of eggs produced and a severe reduction in egg laying and hatching rate. Furthermore, knockdown of the EcR or shade transcripts altered the expression of the chorion gene transcripts Rp30 and Rp45 at day 3 and 6 PBM. These results indicate that ecdysteroids play critical roles in reproduction of female R. prolixus.
From Micro to Macro Gender Differences: Evidence from Field Tournaments
Authors: De Sousa José , Hollard Guillaume 
Published: October 2022

We document that women compete worse against men in field tournaments in over 150 countries and across all ages. Our field setting is the game of chess and we benefit from a large and rich data set to investigate the robustness and heterogeneity of our uncovered gender differences in competition. We find a macro gender gap in every country: there are fewer female than male players, especially at the top, and women have lower average rankings. Moreover, comparing millions of individual games, we find a small but robust micro gender gap: women’s scores are about 2% lower than expected when playing a man rather than a woman with an identical rating, age and country. Using a simple theoretical model, we show how this small micro gap may affect women’s long-run human-capital formation. By reducing effort and increasing the probability of quitting, both effects accumulate to explain a larger share of the macro gap. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Supplemental Material: The e-companion and data are available at https://doi.org/10.1287/mnsc.2022.4541 .
Employment Flexibility and Capital Structure: Evidence from a Natural Experiment
Authors: Kuzmina Olga 
Published: October 2022

Using a unique panel data set of manufacturing firms in Spain in 1994–2006, I show that the use of flexible (shorter and cheaper-to-fire) employment contracts promotes debt financing. I build the identification strategy on the intertemporal, cross-regional, and cross-gender variation in government subsidies that differentially encouraged firms to hire workers on the less flexible contracts. A thought experiment of prohibiting an average firm from hiring workers on flexible contracts suggests that such a firm should reduce its debt-to-capital ratio by 7%. These findings suggest that flexible employment contracts reduce operating leverage and the fixity of firms’ costs, increasing financial leverage. The unique institutional environment allows me to isolate this mechanism from collective bargaining and total labor cost channels. I further show that employment flexibility increases firm performance for firms that benefit most from operating leverage reductions and depend more on external financing. The results demonstrate how management can use heterogenous labor contracts to improve firm outcomes. This paper was accepted by Gustavo Manso, finance. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4560 .
A Rising Tide Lifts All Boats: The Effects of Common Ownership on Corporate Social Responsibility
Authors: DesJardine Mark R. , Grewal Jody , Viswanathan Kala 
Published: October 2022

Common owners face an incredible investment challenge: managing systematic risk. Because common owners hold shares in multiple firms across an industry, an action (or inaction) by one firm that affects industry peers is felt more severely by common owners than by non-common owners. Research has largely focused on common owners’ role in orchestrating competitive dynamics among their portfolio firms, with almost no empirical investigation of how common owners manage systematic risk. Drawing on research showing that one firm’s corporate social responsibility (CSR) can produce positive spillovers for peer firms and that its irresponsibility can harm its peers, we argue that common owners increase firms’ CSR to produce spillovers that reduce systematic risk and multiply their investment returns. Consistent with our theory, we find that common ownership is positively associated with firm CSR. Unpacking that relationship, we find that increases in CSR are driven by common owners with long-term orientations and are concentrated in stakeholder sensitive industries, in which CSR spillovers are most economically impactful. We also find that common owners focus their efforts on financially material CSR over financially immaterial CSR. We use a natural experiment with a quasi-exogenous shock to rule out alternative explanations. Our study contributes to literatures on the antecedents of CSR and outcomes of common ownership, providing a new perspective on how common owners shape corporate strategic behavior. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2022.1620 .
A capability perspective on sustainable employability: A Dutch focus group study on organizational, work and personal conversion factors
Authors: Meerman Jan , van Casteren Patricia A. J. , Brouwers Evelien P. M. , van Dam Arno , van der Klink Jac J. L. 
Published: October 2022

Objective
In the field of work, there is a shift towards more value-based approaches to study the sustainable employability of the present-day worker. The capability approach offers a value based and innovative conceptualisation and framework of sustainable employability characterized by contextuality, normativity and diversity. The capabilities of Dutch employees have been established and validated, yet it is not known which conversion factors on a personal, work and organizational level enable employees to achieve value in work in different Dutch occupational sectors.

Methods
Our qualitative approach included seven focus groups in different occupational sectors including elderly care, higher education, insurance work, facility management and the oil-, car- and chemical industry. Each focus group included 5–11 participants and took approximately one and a half hour. A qualitative content analysis was used to analyse the data, by combining deductive and inductive coding respectively. Deductive coding involved assigning themes to the conversion of resources into capabilities at the organizational, work and personal level.

Results
On the organizational conversion level, important themes were cultural aspects, power relations, shortage of personnel and policies for self-management. On the work conversion level, social contacts, communication and workload, tasks and schedules were identified. Social contacts were described as a work value in itself, but also conditional for achieving other work values. On the personal conversion level, experienced work stress, motivation and the ability to achieve values informally within the company.

Conclusion
From our findings it follows that focus groups are sensitive to identify conversion factors on all three levels of conversion. In addition, companies and their employees might effectively increase work capabilities by being sensitive to all three conversion levels simultaneously. Further research is necessary to study the effect of a capability-based intervention at the work floor.
Ethnodramatherapy: Integrating Research, Therapy, Theatre and Social Activism into One Method, Stephen Snow (2022)
Authors: Bailey Sally 
Published: October 2022

Review of: Ethnodramatherapy: Integrating Research, Therapy, Theatre and Social Activism into One Method, Stephen Snow (2022)
London: Routledge and Taylor & Francis, 304 pp.,
ISBN 978-0-36753-947-4, p/bk, $39.95
Creative Arts Therapy Careers: Succeeding as a Creative Professional, Sally Bailey (ed.) (2022)
Authors: Lukic Venus 
Published: October 2022

Review of: Creative Arts Therapy Careers: Succeeding as a Creative Professional, Sally Bailey (ed.) (2022)
New York: Routledge, 258 pp.,
ISBN 978-0-36747-652-6, h/bk, $128
ISBN 978-0-36747-653-3, p/bk, $27.96
ISBN 978-1-00303-566-4, e/bk, $27.96
Comparison of MANTA vs ProGlide Vascular Closure Device and 30-Day Outcomes in Transfemoral Transcatheter Aortic Valve Implantation
Authors: Eftychiou Christos , Eteocleous Nicolaos , Mitsis Andreas , Zittis Ioannis , Papadopoulos Kyriacos , Petrou Andria , Adamou Maria , Kounnos Christos , Bekos Christos , Avraamides Panayiotis 
Published: October 2022

Background
Vascular complications (VCs) after transfemoral transcatheter aortic valve implantation (TAVI) have an increased mortality risk, and vascular closure device (VCD) use is mandatory. The percutaneous MANTA VCD (Teleflex) is a novel collagen-based technology for closure of large-bore arteriotomies. We compared the MANTA VCD with the suture-based ProGlide VCD (Abbott Vascular).

Methods
A retrospective review was performed on all consecutive patients who underwent transfemoral TAVI in our center from January 1, 2015, to February 28, 2021, and 30-day outcomes were recorded. Major adverse cardiovascular events (MACE) were cardiac death, disabling stroke, and/or major VCs. Access site–related VCs were VCs related to the access site vessel from which the transcatheter valve was introduced and advanced.

Results
The MANTA VCD was used in 99 patients and the ProGlide in 224. There was 4.0% MACE in the MANTA group and 4.9% in the ProGlide group (P = .999). Overall VCs were 10.1% vs 7.6%, major VCs were 3.0% vs 2.2%, and minor VCs 7.1% vs 5.4%(P = .753). Access site–related VCs were 5.1% vs 5.8% in the (P = .999), and periprocedural vascular surgical intervention was needed in 6.1% of the MANTA group vs 2.2% of the ProGlide group (P = .099).

Conclusion
There was no significant difference in MACE, mortality, cardiovascular mortality, VCs, access site–related VCs, periprocedural vascular surgical interventions, bleeding, or transfusion rate between the 2 groups. The MANTA VCD group had more periprocedural vascular surgical interventions which did not reach statistical significance.
MACROSCOPICS AND MICROSCOPICS FEATURE OF WITAR RATS LIVER AFTER IMMERSION IN GRADUAL CONCENTRATION OF RANDU HONEY
Authors: Kusuma Putri Ariani , Dhanardhono Tuntas , Saebani Saebani , Purnawati Ratna Damma , Istiadi Hermawan 
Published: October 2022

Background Formaldeyde is main substance used for organ embalming and even for foods preservations. However, long and high exposure of formaldeyhde lead to various organs irritations. Honey is well-known for its natural preservative activity expected to be the soultion for the problem so there is safe alternative for organ preservations.Aim Observation and examintaion the difference of macroscopic and microscopics feature of Wistar rats liver after immersion of formaldehyde and randu honey.Methods Experimental with post-test only control group design using 24 male Wistar rats as sample, randomly divided into 4 groups consist of: Group C (preserved with 10% formaldehyde solutions), P1 (preserved with 10% randu honey solutions), P2 (preserved with 20% randu honey solutions) and P3 (preserved with 30% randu honey solutions). The sampels were preserved for 24 hours then macroscopic (smell,color and size) and microscopic study with Hematoxylin-Eosin (HE) stain using 400x observation performed. Manja Roenigk score were used to accessed the degree of live microsopic damage.Results There are normal cells, mild damage, moderate damage and severe damage respectively in the group C: 36%,47%,17%,0% ; P1: 0%,27%,46%,27% ; P2: 0%,77%,17%,6% ; P3: 47%,33%,17%,3%. Kruskal-Wallis test showed significant results with p=0.000. With Mann-Whitney test, significant results were found between group C with P1 (0.000), C with P2 (0.006), P1 with P2 (0.000), P1 with P3 (0.000) and P2 with P3 (0.003). However, test result were not significant berween group C with P3 (0.684).Conclusions There were differences in macroscopics and microscopic features between Wistar rats liver after immersion in formaldehyde and randu honey. The best features showed in samples preserved in 30% Randu Honey solutions.
PENGARUH PENGELUARAN PEMERINTAH, INVESTASI, JUMLAH PENDUDUK, KEMISKINAN TERHADAP PERTUMBUHAN EKONOMI DAN INDEKS PEMBANGUNAN MANUSIA: Analisa Two Stage Least Square untuk Kasus Indonesia
Authors: Simarmata Yuli Wantri , Iskandar Deden Dinar 
Published: October 2022

Indeks pembangunan manusia merupakan suatu indeks komposit untuk mengukur capaian pembangunan manusia berbasis sejumlah komponen dasar kualitas hidup. Pertumbuhan ekonomi merupakan kunci dari penurunan kemiskinan disuatu wilayah, dengan adanya pertumbuhan ekonomi berarti terdapat peningkatan produksi sehingga menambah lapangan pekerjaan yang pada akhirnya akan mengurangi kemiskinan maka indeks pembangunan manusia akan dapat dinilai meningkat. Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh pertumbuhan ekonomi terhadap indeks pembangunan manusia serta melihat faktor-faktor yang mempengaruhi pertumbuhan ekonomi dan indeks pembangunan manusia di Indonesia. Analisis data dalam penelitian menggunakan data panel 34 provinsi di Indonesia Tahun 2013-2018. Dalam mengestimasi structure equation model (SEM) dalam penelitian ini menggunakan metode Two Stage Least Square (TSLS). Hasil penelitian ini menunjukan bahwa variabel pertumbuhan ekonomi berpengaruh signifikan terhadap indeks pembangunan manusia.
Analisis Kekuatan Massa Batuan dan Stabilitas Lereng Intake Bendungan Bener Berdasarkan Metode Empiris, Analitis, dan Numerik
Authors: Danuartha Muhammad Satya Himawan , Widianto Hendratama 
Published: October 2022

Berdasarkan hasil redesain terowong pengelak Bendungan Bener memiliki panjang trase ±853 m, dengan tinggi lereng intake dan inlet sebesar 130 m. Fungsi bendungan ini selama konstruksi berlangsung digunakan untuk mengalihkan aliran Sungai Bogowonto, tetapi ketika operasional berfungsi sebagai bangunan pengambilan untuk air baku dan PLTA. Penelitian ini menyajikan hasil investigasi geologi teknik galian intake dan portal inlet terowong pengelak Bendungan Bener. Karakteristik massa batuan diperoleh dari pemetaan geologi teknik (scanline). Sifat indeks dan keteknikan batuan diperoleh dari hasil laboratorium sampel batuan. Analisis stabilitas lereng pada intake dengan metode empiris dilakukan berdasarkan klasifikasi massa batuan, metode analitis berdasarkan metode ambang batas kesetimbangan, metode numerik berdasarkan metode elemen hingga. Investigasi geologi menunjukkan lokasi terowongan tersusun oleh breksi andesit, yang merupakan bagian dari Formasi Kebo Butak. Massa batuan pada area studi galian intake dominan segar dan lapuk ringan berdasarkan Rock Mass Rating, RMR juga diklasifikasikan sebagai massa batuan kelas I (massa batuan sangat bagus) dan kelas II (massa batuan bagus). Berdasarkan Slope Mass Rating, desain lereng inlet berada pada kelas II (stabil). Hasil analisis stabilitas sumbu utama lereng intake alami dan setelah penggalian menggunakan metode ambang batas kesetimbangan dan metode elemen hingga berada pada kondisi aman (Faktor keamanan >1,5).
PENGARUH PERSEPSI KEMUDAHAN PENGGUNAAN DAN PERSEPSI KEAMANAN TERHADAP KEPUTUSAN PENGGUNAAN OVO PT VISIONET DATA INTERNASIONAL (STUDI PADA PENGGUNA OVO DI KOTA SURAKARTA)
Authors: Iliyin Ahmad , Widiartanto Widiartanto 
Published: October 2022

Increasing competition for e-money, one payment service that is growing rapidly is OVO, an online payment service providers based application. The amount of OVO users has been decreased although target achievement increased in its realization but in the percentage of changes there has been a sharp decline. The type of research using explanatory research with data collecting technics by interview and data collection tools used offline and online questionnaires. The methods of this study is purposive sampling with a sample of 100 respondents. Data analysis technique in this study using validity test, reliability test, simple linear regression, multiple linear regression, t-test, and F- test with SPSS 25.0. The result of research indicate that variable perceived ease of use is positive effect of decision to use OVO in Surakarta city. Variable Peceived security is positive effect of decision to use OVO in Surakarta city. Variable preceived ease of use and variable preceived security significantly is positive effect of decision to use OVO in Surakarta city. Based on the results of the study, the researcher suggested that Visionet data internasional company can assure its users of user data in OVO application that it has secured its confidentiality, so that users do not worry about excessive amounts, and supports OVO providing education for use using OVO interest in decisions using OVO.