bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutritional impact of mycotoxins in food animal production and strategies for mitigation
Authors: Xu Ran , Kiarie Elijah G. , Yiannikouris Alexandros , Sun Lvhui , Karrow Niel A. 
Published: June 2022

AbstractMycotoxins are toxic secondary metabolites produced by filamentous fungi that are commonly detected as natural contaminants in agricultural commodities worldwide. Mycotoxin exposure can lead to mycotoxicosis in both animals and humans when found in animal feeds and food products, and at lower concentrations can affect animal performance by disrupting nutrient digestion, absorption, metabolism, and animal physiology. Thus, mycotoxin contamination of animal feeds represents a significant issue to the livestock industry and is a health threat to food animals. Since prevention of mycotoxin formation is difficult to undertake to avoid contamination, mitigation strategies are needed. This review explores how the mycotoxins aflatoxins, deoxynivalenol, zearalenone, fumonisins and ochratoxin A impose nutritional and metabolic effects on food animals and summarizes mitigation strategies to reduce the risk of mycotoxicity.
Evaluating social sustainability in Jordanian residential neighborhoods: a combined expert-user approach
Authors: Sharif Ahlam Ammar , Alshdiefat Ala’a Saleh , Rana Muhammad Qasim , Kaushik Amit , Oladinrin Olugbenga Timo 
Published: June 2022

AbstractNeighborhood sustainability has assumed a pole position as a topic of interest in the past years, addressed through dedicated strands of most of the globally adopted sustainability rating tools, such as LEED and BREEAM. Considering sustainability assessment, the social sustainability of neighborhoods assumes a certain particularity, not only in terms of its high context dependence pertaining to its locality, but in its means of assessment as well, with people as a key potential evaluator for matters that are not bound to quantitative aspects. This research focused on developing a framework for rating social sustainability in neighborhoods, utilizing a quantitative approach that builds upon insights obtained by an extended group of experts and end users. It combines the Delphi and AHP techniques along with the case study approach to develop a framework that suits the Jordanian local context, where a particular neighborhood, Dahiyat Al Hussein in Amman, is used for validation. The research revealed that rating the social sustainability of neighborhoods is not only highly guided by the local context it addresses, but is also reliant on the level of understanding and adoption of the concept itself as attained by the people.
Evaluating a novel 3D printed model for simulating Large Loop Excision of the Transformation Zone (LLETZ)
Authors: Kiesel Matthias , Beyers Inga , Kalisz Adam , Wöckel Achim , Löb Sanja , Schlaiss Tanja , Wulff Christine , Diessner Joachim 
Published: June 2022

Abstract
Background
Electrosurgical excisions are common procedures for treating cervical dysplasia and are often seen as minor surgeries. Yet, thorough training of this intervention is required, as there are considerable consequences of inadequate resections, e.g. preterm birth, the risk of recurrence, injuries and many more. Unfortunately, there is a lack of sufficiently validated possibilities of simulating electrosurgeries, which focus on high fidelity and patient safety.

Methods
A novel 3D printed simulator for examination and electrosurgical treatment of dysplastic areas of the cervix was compared with a conventional simulator. Sixty medical students experienced a seminar about cervical dysplasia. Group A underwent the seminar with the conventional and Group B with the novel simulator. After a theoretical introduction, the students were randomly assigned by picking a ticket from a box and went on to perform the hands-on training with their respective simulator. Each student first obtained colposcopic examination training. Then he or she performed five electrosurgical excisions (each). This was assessed with a validated score, to visualize their learning curve. Furthermore, adequate and inadequate resections and contacts between electrosurgical loop and vagina or speculum were counted. Both groups also assessed the seminar and their simulator with 18 questions (Likert-scales, 1–10, 1 = strongly agree / very good, 10 = strongly disagree / very bad). Group B additionally assessed the novel simulator with four questions (similar Likert-scales, 1–10).

Results
Nine of 18 questions showed statistically significant differences favoring Group B (p < 0.05). Group B also achieved more adequate R0-resections and less contacts between electrosurgical loop and vagina or speculum. The learning curves of the performed resections favored the novel simulator of Group B without statistically significant differences. The four questions focusing on certain aspects of the novel simulator indicate high appreciation of the students with a mean score of 1.6 points.

Conclusion
The presented novel simulator shows several advantages compared to the existing model. Thus, novice gynecologists can be supported with a higher quality of simulation to improve their training and thereby patient safety.
Two face masks are better than one: congruency effects in face matching
Authors: Estudillo Alejandro J. , Wong Hoo Keat 
Published: June 2022

AbstractAlthough the positive effects of congruency between stimuli are well replicated in face memory paradigms, mixed findings have been found in face matching. Due to the current COVID-19 pandemic, face masks are now very common during daily life outdoor activities. Thus, the present study aims to further explore congruency effects in matching faces partially occluded by surgical masks. Observers performed a face matching task consisting of pairs of faces presented in full view (i.e., full-view condition), pairs of faces in which only one of the faces had a mask (i.e., one-mask condition), and pairs of faces in which both faces had a mask (i.e., two-mask condition). Although face masks disrupted performance in identity match and identity mismatch trials, in match trials, we found better performance in the two-mask condition compared to the one-mask condition. This finding highlights the importance of congruency between stimuli on face matching when telling faces together.
First-line (1L) nivolumab (NIVO) + ipilimumab (IPI) + 2 cycles of chemotherapy (chemo) versus chemo alone (4 cycles) in patients (pts) with metastatic non–small cell lung cancer (NSCLC): 3-year update from CheckMate 9LA.
Authors: Paz-Ares Luis G. , Ciuleanu Tudor-Eliade , Cobo-Dols Manuel , Bennouna Jaafar , Cheng Ying , Mizutani Hideaki , Lingua Alejo , Reyes Felipe , Reinmuth Niels , Janoski De Menezes Juliana , Jassem Jacek , Protsenko Svetlana , Feeney Kynan , De La Mora Jimenez Emmanuel , Lu Shun , John Tom , Carbone David Paul , Zhang Xiaoqing , Hu Nan , Reck Martin 
Published: June 2022

LBA9026 Background: In CheckMate 9LA (NCT03215706), 1L NIVO + IPI combined with 2 cycles of chemo was shown to provide survival benefit vs chemo alone in pts with metastatic NSCLC. Here, we report updated efficacy and safety with a 3-year minimum follow-up, as well as exploratory biomarker analyses from this study. Methods: Adults with stage IV or recurrent NSCLC, no known sensitizing EGFR/ ALK alterations, and ECOG performance status ≤ 1 were randomized 1:1 to NIVO 360 mg Q3W + IPI 1 mg/kg Q6W + 2 cycles of chemo (n = 361) or 4 cycles of chemo alone (n = 358). Pts were stratified by tumor PD-L1 expression, sex, and histology. Pts with non-squamous (NSQ) NSCLC in the chemo-alone arm could receive pemetrexed maintenance. Assessments included overall survival (OS), progression-free survival (PFS), and objective response rate (ORR). For all pts with NSQ NSCLC and with tissue evaluable for mutational analysis (n = 313), the FoundationOne CDxTM assay was used to identify mutant (mut) or wild type (wt) KRAS and STK11 genes. Exploratory assessments included evaluation of OS and PFS with NIVO + IPI + chemo vs chemo by mutation status and safety. Results: At a minimum follow-up of 36.1 mo (database lock: Feb 15, 2022), pts continued to derive long-term, durable OS benefit with NIVO + IPI + chemo vs chemo (HR, 0.74 [95% CI, 0.62–0.87]); 3-y OS rates were 27% vs 19%. Clinical benefit with NIVO + IPI + chemo vs chemo was observed in all randomized pts and across most subgroups, including by PD-L1 expression level (Table) or histology. In an exploratory analysis in pts evaluable for mutations including KRAS and STK11, OS appeared to be improved with NIVO + IPI + chemo vs chemo (median OS, 16.3 vs 13.1 mo). Similar trends of prolonged OS with NIVO + IPI + chemo vs chemo were also seen in pts with or without KRAS mutation (median OS, mut: 19.2 vs 13.5 mo; wt: 15.6 vs 12.7 mo) or STK11 mutation (mut: 13.8 vs 10.7 mo; wt: 17.8 vs 13.9 mo), respectively. Additional efficacy outcomes will be presented. No new safety signals were identified with extended follow-up. Conclusions: With a 3-year minimum follow-up, 1L NIVO + IPI + chemo demonstrated long-term, durable efficacy benefit vs chemo in pts with metastatic NSCLC. Survival benefit of NIVO + IPI + chemo vs chemo was observed regardless of KRAS and STK11 mutation status. Clinical trial information: NCT03215706. [Table: see text]
Theorizing Law, Social Movements, and State Formation in India
Authors: Nilsen Alf Gunvald , Nielsen Kenneth Bo , Vaidya Anand 
Published: June 2022

Abstract
With the rise of Hindu nationalist statecraft under the Modi regime, India finds itself at a perilous conjuncture that compels a critical rethinking of the political economy of the world's largest democracy. In this article, we propose a conceptual framework for doing so, centered on a Gramscian rethinking of the relationship among law, social movements, and state formation in the longue durée of Indian democracy. Working across three hegemonic transitions in Indian democracy, we argue that social movements and the state have constituted each other across this longue durée, and that this co-constitution has been both mediated by and inscribed in law. Crucially, we focus on the making and unmaking of compromise equilibriums between dominant and subaltern social forces in state-society relations in and through law and legal formations from the transition to independence, via the unravelling of the Nehruvian state, to the present moment of neoliberalization and authoritarian populism. The article is organized around three analytical concerns—law and hegemony, state formation as a hegemonic process, and the dialectic of power and resistance in passive revolution. In the conclusion, we bring our reflections to bear on the current conjuncture in Indian democracy.
The Surplus of Death
Authors: Avramopoulou Eirini 
Published: June 2022

Abstract
This article focuses on the temporal and spatial proximity mediating the lives of those who have been institutionalized in distinctive (albeit similar) ways on the Greek island of Leros, like asylum seekers and the mentally ill—and those working in asylum institutions—who appear co-implicated in the circuit of crisis capitalism and the biopolitical/necropolitical effects of managing populations deemed disposable in the name of care and protection. Drawing closely on the double meaning of the term asylum, this article explores the gendered and racialized biopolitical apparatus of vulnerability management in asylum contexts, especially the deadness and livingness they produce. It argues that complicity arises within the dense atmosphere of the surplus of death and the unattainable accumulation produced by multiple crises. It approaches the associated “surplus of death” as essential to the political economy of asylum management, which operates on a logic of “slow death” and the wearing out of populations struggling to endure its unbearable affects. This affective atmosphere is imbued with ethico-political questions that are neither owned by particular subjects nor disavowed in their universal reach but sustained (in their unsustainability) through norms and morals reiterated in their articulation, sense-making trouble, and measurement of worth.
Introduction
Authors: Moon Young Min 
Published: June 2022

We are pleased and honored, as we enter our third year of publication, to publish this special issue of the Trans-Asia Photography Review, The Aftereffects of War in Asia: Histories, Pictures, and Anxieties, guest edited by Professor Young Min Moon of the University of Massachusetts. An artist, writer, and curator, Moon brings to this project many years of engagement with issues of militarism and the residues of war in the context of South Korean art. For this issue, in addition to his own contributions, he has translated three essays by other Korean artists and scholars, making them available in English for the first time. However, the scope of the issue also goes beyond the concerns of the Korean peninsula. Concentrating in depth on specific situations throughout Asia, the issue raises awareness, with subtlety and complexity, of the multi-faceted and enduring legacies of wars. We hope that the ideas and information presented here will stimulate further work on this important topic.
Sandra Matthews, Editor
Trans-Asia Photography Review
Actin assembly requirements of the formin Fus1 to build the fusion focus
Authors: Billault-Chaumartin Ingrid , Michon Laetitia , Anderson Caitlin A. , Yde Sarah E. , Suarez Cristian , Iwaszkiewicz Justyna , Zoete Vincent , Kovar David R. , Martin Sophie G. 
Published: June 2022

ABSTRACT
In formin-family proteins, actin filament nucleation and elongation activities reside in the formin homology 1 (FH1) and FH2 domains, with reaction rates that vary by at least 20-fold between formins. Each cell expresses distinct formins that assemble one or several actin structures, raising the question of what confers each formin its specificity. Here, using the formin Fus1 in Schizosaccharomyces pombe, we systematically probed the importance of formin nucleation and elongation rates in vivo. Fus1 assembles the actin fusion focus, necessary for gamete fusion to form the zygote during sexual reproduction. By constructing chimeric formins with combinations of FH1 and FH2 domains previously characterized in vitro, we establish that changes in formin nucleation and elongation rates have direct consequences on fusion focus architecture, and that Fus1 native high nucleation and low elongation rates are optimal for fusion focus assembly. We further describe a point mutant in Fus1 FH2 that preserves native nucleation and elongation rates in vitro but alters function in vivo, indicating an additional FH2 domain property. Thus, rates of actin assembly are tailored for assembly of specific actin structures.
Understanding factors associated with continuation of use of injectable contraceptives in Karnataka and Maharashtra, India: a cross-sectional household study
Authors: Singal Sunita , Sikdar S K , Kaushik S , Kniss Jennifer , Singh Pragati , Bhatt Nidhi , Samandari Ghazaleh , Pal Manoj , Dere Harshwardhan , Cagatay Levent , O’Connell Kathryn A 
Published: June 2022

The Government of India has worked to expand access to injectable contraceptives through the introduction of a three-monthly injectable contraceptive MPA under the ‘Antara’ program in 2017. However, the uptake of injectable contraceptives has remained low, and few studies have investigated the experiences of public health facility injectable clients in India. We examined factors associated with continuing, discontinuing, and switching methods among injectable users obtaining services from public health facilities in the Indian states of Karnataka and Maharashtra. The study team recruited respondents (N=1009) that had received their first injectable dose from in public sector facilities between February – May 2019 and conducted a follow-up visit at their residence in December 2020. We used multivariate logistic regression to study the association of the demographic characteristics, service quality, satisfaction with services, follow-up visits, and decision-making on injectable continuation and switching to other family planning methods. Injectable usage rates declined significantly, with 44% of clients receiving a second dose and only 16% receiving a third dose. Over half of women (54%) cited problems related to periods as the reason for discontinuing injectable use after the first dose. Respondents were more likely to continue their method at third dose if they were older (25-35 years) (OR:1.68, p<0.05) and had received a reminder for a follow-up dose (OR: 2.41, p Our results also highlight the importance of addressing side-effects experience by women, which may be better managed by community-based follow-up visits and high-quality counselling services.
Cladding mode characteristics simulation of an excessively tilted fiber grating coated with gold nanoshells
Authors: Liu Kaijun , Luo Binbin , Wu Decao , Gu Hong , Yang Xiangwen 
Published: June 2022

The cladding mode characteristics simulation of an excessively tilted fiber grating (ExTFG) coated with gold nanoshells was conducted in this study. First, the effective refractive indices of the core and cladding mode before coating were obtained by solving the eigenvalue equation of the three-layer waveguide structure, and the coupling characteristics were briefly analyzed. Then

H
E

1
,
m

and

E
H

1
,
m

modes were selected as the research objects, and the spectral characteristics of ExTFG coated with gold nanoshells were simulated by the finite element method. The simulated refractive index sensitivity of

H
E

1
,
29

and

E
H

1
,
29

modes is 160.16 and 185.03 nm/RIU, respectively. Compared with the non-localized surface plasmon resonance (LSPR) effect, it increased by 10.76 nm/RIU (7.2%) and 19.53 nm/RIU (11.8%), respectively. Thus, the LSPR effect was verified to be beneficial to improve the refractive index sensitivity of ExTFG.
Snapshot spectral compressive imaging reconstruction using convolution and contextual Transformer
Authors: Wang Lishun , Wu Zongliang , Zhong Yong , Yuan Xin 
Published: June 2022

Spectral compressive imaging (SCI) is able to encode a high-dimensional hyperspectral image into a two-dimensional snapshot measurement, and then use algorithms to reconstruct the spatio-spectral data-cube. At present, the main bottleneck of SCI is the reconstruction algorithm, and state-of-the-art (SOTA) reconstruction methods generally face problems of long reconstruction times and/or poor detail recovery. In this paper, we propose a hybrid network module, namely, a convolution and contextual Transformer (CCoT) block, that can simultaneously acquire the inductive bias ability of convolution and the powerful modeling ability of Transformer, which is conducive to improving the quality of reconstruction to restore fine details. We integrate the proposed CCoT block into a physics-driven deep unfolding framework based on the generalized alternating projection (GAP) algorithm, and further propose the GAP-CCoT network. Finally, we apply the GAP-CCoT algorithm to SCI reconstruction. Through experiments on a large amount of synthetic data and real data, our proposed model achieves higher reconstruction quality (

>
2

dB

in peak signal-to-noise ratio on simulated benchmark datasets) and a shorter running time than existing SOTA algorithms by a large margin. The code and models are publicly available at https://github.com/ucaswangls/GAP-CCoT.
Pharmacogenomics decision support in the U-PGx project: Results and advice from clinical implementation across seven European countries
Authors: Blagec Kathrin , Swen Jesse J. , Koopmann Rudolf , Cheung Ka-Chun , Crommentuijn - van Rhenen Mandy , Holsappel Inge , Konta Lidija , Ott Simon , Steinberger Daniela , Xu Hong , Cecchin Erika , Dolžan Vita , Dávila-Fajardo Cristina Lucía , Patrinos George P. , Sunder-Plassmann Gere , Turner Richard M. , Pirmohamed Munir , Guchelaar Henk-Jan , Samwald Matthias ,   Ubiquitous Pharmacogenomics Consortium
Published: June 2022

Background
The clinical implementation of pharmacogenomics (PGx) could be one of the first milestones towards realizing personalized medicine in routine care. However, its widespread adoption requires the availability of suitable clinical decision support (CDS) systems, which is often impeded by the fragmentation or absence of adequate health IT infrastructures. We report results of CDS implementation in the large-scale European research project Ubiquitous Pharmacogenomics (U-PGx), in which PGx CDS was rolled out and evaluated across more than 15 clinical sites in the Netherlands, Spain, Slovenia, Italy, Greece, United Kingdom and Austria, covering a wide variety of healthcare settings.

Methods
We evaluated the CDS implementation process through qualitative and quantitative process indicators. Quantitative indicators included statistics on generated PGx reports, median time from sampled upload until report delivery and statistics on report retrievals via the mobile-based CDS tool. Adoption of different CDS tools, uptake and usability were further investigated through a user survey among healthcare providers. Results of a risk assessment conducted prior to the implementation process were retrospectively analyzed and compared to actual encountered difficulties and their impact.

Results
As of March 2021, personalized PGx reports were produced from 6884 genotyped samples with a median delivery time of twenty minutes. Out of 131 invited healthcare providers, 65 completed the questionnaire (response rate: 49.6%). Overall satisfaction rates with the different CDS tools varied between 63.6% and 85.2% per tool. Delays in implementation were caused by challenges including institutional factors and complexities in the development of required tools and reference data resources, such as genotype-phenotype mappings.

Conclusions
We demonstrated the feasibility of implementing a standardized PGx decision support solution in a multinational, multi-language and multi-center setting. Remaining challenges for future wide-scale roll-out include the harmonization of existing PGx information in guidelines and drug labels, the need for strategies to lower the barrier of PGx CDS adoption for healthcare institutions and providers, and easier compliance with regulatory and legal frameworks.
A pilot course with project-based learning in an intensive English program
Authors: Ennis Michael Joseph , Barchi Kim Anne , Merello Astigarraga Alfonso , Wimhurst Andrew 
Published: June 2022

AbstractIntensive language programs have increased in popularity in recent years. They are perceived as a means to help current or prospective university students improve their language competencies and academic skills in their medium(s) of instruction in a short amount of time prior to enrolment and/or parallel to their degree courses. However, there has been little empirical research on practices and efficacies of such programs. This paper presents a pilot project conducted during a pre-sessional intensive English course for first-year students at a trilingual university in Italy. Specifically, the project employed a mixed-method approach to explore the differences between project-based learning (PBL) and the practice of teaching from a coursebook. The results suggest that while there was no difference in learner engagement and learning outcomes between a pilot group which engaged exclusively in PBL and a control group which was taught from a coursebook, the participants expressed particularly positive attitudes to PBL, although they also expressed a desire for more teacher-led instruction. The findings merit further investigation of PBL in this and similar contexts, including the longitudinal effects of PBL and the trialling of different combinations of PBL with explicit and deductive instruction.