bluuebunny/crossref_metadata_2025_split huggingface dataset:
Failure of primary ACL repair with dynamic intraligamentary stabilization may result in a high risk of two-stage ACL reconstruction: a case series of ten patients
Authors: Cristiani Riccardo , Mouton Caroline , Siboni Renaud , Pioger Charles , Seil Romain 
Published: August 2022

Abstract
Purpose

Dynamic Intraligamentary Stabilization (DIS) is a technique for the repair of acute anterior cruciate ligament (ACL) injuries. The purpose of this study was to investigate the potential challenges of ACL reconstruction (ACLR) following failure of DIS.

Methods
A retrospective analysis of patients with failure of primary ACL repair performed with DIS was undertaken. Failure was defined as abnormal knee laxity (positive Lachman and/or pivot shift) and/or severely restricted range of motion. Medical and surgical records were reviewed and preoperative standard anteroposterior and lateral X-rays were assessed.

Results
Between July 2015 and May 2022, 10 patients (3 males, 7 females, median age 28 years, range 18–52 years) with failure of DIS were referred to and surgically treated at a single centre. In four patients, single-stage ACLR was performed following the removal of the tibial monoblock. In six patients, arthrofibrosis and excessive tibial tunnel enlargement following the removal of the monoblock prevented single-stage ACLR. These patients underwent arthroscopic arthrolysis and tibial tunnel bone grafting as a first-stage revision procedure.

Conclusion
In the present case series, single-stage ACLR was performed in only four (40%) of ten patients following failure of ACL repair with DIS. Arthrofibrosis and excessive tibial tunnel enlargement following the removal of the monoblock prevented single-stage ACLR in six (60%) patients. It is important for clinicians to inform patients that, in the event of failure of ACL repair with DIS, they may run a high risk of undergoing two-stage ACLR.

Level of Evidence
Level IV, Case Series.
The role of probiotics in the treatment of adult atopic dermatitis: a meta-analysis of randomized controlled trials
Authors: Umborowati Menul Ayu , Damayanti Damayanti , Anggraeni Sylvia , Endaryanto Anang , Surono Ingrid S. , Effendy Isaak , Prakoeswa Cita Rosita Sigit 
Published: August 2022

Abstract
Background
Atopic dermatitis (AD) is chronic inflammatory skin disease that is relapsing and a serious condition that disrupts the quality of life of affected individuals. Probiotics are an immunomodulator that can enhance the immune control of atopic dermatitis.

Methods
All randomized controlled trials of probiotics for the treatment of adult AD published before December 2020 were included in this study from the PubMed databases and manual searching.

Results
Six randomized controlled trials (n = 241) were selected for this meta-analysis study. Probiotics were effective in treating adult patients with AD, indicated by the decrease in Scoring Atopic Dermatitis/SCORAD (Mean Difference (MD)  − 7.90, 95% CI − 7.25 to − 6.92; p < 0.00001; I2 = 96%) and improved quality of life (MD − 7.68, 95% CI − 14.08 to − 1.29; p = 0.02; I2 = 47%) which were statistically significant. However, skin severity, itch severity, Dermatology Life Quality Index (DLQI), IL-4, TFN-γ, and IgE showed no significant difference in this meta-analysis study (p > 0.05).

Limitations
The study found no available data for side effects of probiotics.

Strength
This meta-analysis analyzed a total of 241 AD patients of Asian and European origin.

Conclusion
The use of probiotics decreased SCORAD significantly in adult patients with AD. Probiotics can improve the quality of life of patients with AD.

Capsule summary
The use of probiotics in atopic dermatitis has been widely studied, with controversial results. This meta-analysis suggests that the use of probiotics can improve SCORAD and the quality of life of patients with atopic dermatitis.
Effects of hydrophilic polymer-embedded membrane on permeability and cell adhesion during continuous hemofiltration
Authors: Kobayashi Kozue , Kurihara Yoshitaka , Ueki Shunichi , Kokubo Kenichi , Kubota Masaru , Kobayashi Hirosuke 
Published: August 2022

Abstract
Background and Aims
Clotting within the membrane and/or venous ‘air trap’ chamber is common problems during continuous blood purification therapy. Frequent clotting during continuous blood purification therapy leads to inadequate solute removal, an increased circuit and filter cost, and an increased burden for the medical staff. Improvements in filter membrane materials may reduce the extent of clotting and prolong the filter life. The purpose of the present study was to clarify the characteristics of an NV polymer-embedded membrane (NV-PS) after long-term use, especially the adhesiveness of blood cells and changes in the solute removal performance.

Methods
Continuous hemofiltration (CHF) experiments using a permeate recycle mode were performed for 24 h using the same porcine whole blood divided into two portions to compare the NV-PS with a conventional polysulfone membrane (PS). The activated clotting time was adjusted to within a range of 300–400 s. The change in the dextran sieving coefficient (SC) of the membrane and the residual blood clots in the filters were evaluated after the completion of the CHF experiment.

Results
The increase in the transmembrane pressure and the pressure drop of the hemofilter were significantly smaller using the NV-PS than with the PS. For larger molecules (SC $$ \leqq $$
≦
0.4), the reduction in SC after blood contact was significantly smaller for the NV-PS. Fewer blood cells remained in the residual blood clots when the NV-PS was used.

Conclusion
NV-PS has the advantages of showing a lower degree of reduction of the solute removal performance and also a lower degree of clogging of the hollow fibers during prolonged circulation. These characteristics may be expected to be advantageous when this membrane is used for continuous blood purification therapy in acute-phase patients.
Melatonin as a treatment for migraine sufferers: a systematic review
Authors: Adnyana I Made Oka , Tertia Clarissa , Widyadharma I Putu Eka , Mahadewi Ni Putu Ayu Putri 
Published: August 2022

Abstract
Background
Migraine is a primary headache with a prevalence of 12–20% in the world. Approximately 38% sufferers were indicated for prophylactic therapy, but only a small proportion (3–13%) received prophylactic therapy. The role of melatonin in migraine is to protect the brain against toxins through anti-free radical activity, inhibition of the release of inflammatory factors and neurotransmitters.

Results
This review uses the PRISMA protocol and uses source from Pubmed. A total of 142 articles were found according to the search strategy. 5 articles were collected with a randomized-controlled trial design that matched the inclusion criteria. Of the 5 articles, there were only 2 articles that proved significant where melatonin gave better results compared to placebo in migraine sufferers, especially in the frequency of attacks, duration, and reduction in the use of other analgesics. Based on the dose and duration of melatonin administration, although most use a dose of 3 mg melatonin with a duration of 2–3 months, this still needs to be investigated further because the available data are not sufficient. In addition, the use of melatonin before going to bed at night is said to be better because it is associated with the majority of side effects that occur, namely sleepiness.

Conclusion
Studies on melatonin and migraine with a randomized-controlled trial design are still limited so there is not enough evidence to support the administration of melatonin as a treatment for migraine sufferers, including the safety and side effects, especially for a long period of time.
Nurses’ perception and compliance with personal protective equipment and hand hygiene during the third wave of COVID-19 pandemic
Authors: Elshaer Noha , Agage Hesham 
Published: August 2022

Abstract
Background
Healthcare workers' (HCWs) compliance with infection prevention and control (IPC) measures during the COVID-19 pandemic is crucial to reducing the spread of infection to their colleagues, families, and community. This study assessed the risk perception and compliance with personal protective equipment (PPE) usage, hand hygiene, and specific IPC measures and explored the factors associated with compliance among nurses during the third wave of the COVID-19 pandemic in Egypt.

Methods
A hospital-based cross-sectional survey was conducted at the Alexandria Main University Hospital (AMUH) in Alexandria city from May to August 2021, where 354 nurses were included with a response rate of 94.9%. A structured interviewer-administered questionnaire was used for data collection. Univariate and multivariate logistic regression analyses were conducted.

Results
The overall compliance with PPE usage, hand hygiene, and IPC measures was 81.9%. The mean risk perception score was 40.9 ± 3.3. More than 95% of nurses were aware of the high risk of COVID-19 infection at their workplace, the serious consequences of the disease, and the risk that can be minimized by using PPE, whereas a relatively low percentage of nurses believed that the risk of COVID-19 infection could be reduced by using a surgical mask (19.2%) or gloves (50.5%). Good compliance was independently predicted by risk perception (OR = 1.25; 95% CI = 1.13, 1.39), and knowledge about PPE usage and hand hygiene (OR = 3.53; 95%CI = 2.40, 5.19). Facilitators of compliance with the PPE usage were attending suspected or confirmed COVID-19 cases in their hospital ($$\overline{x}$$

x
¯

= 9.82), comfort to use the PPE ($$\overline{x}$$

x
¯

= 9.16), availability of PPE ($$\overline{x}$$

x
¯

= 8.96), hospital policy ($$\overline{x}$$

x
¯

= 8.74), and senior compliance ($$\overline{x}$$

x
¯

= 6.5).

Conclusions
Nurses at AMUH reported high risk perceptions. The rate of compliance with PPE usage, hand hygiene, and IPC measures was 81.9%. The personal risk perception and knowledge about the PPE usage and hand hygiene are the keys to improving compliance in a healthcare facility.
Vaccine development against Schmallenberg virus: from classical inactivated to modified-live to scaffold particle vaccines
Authors: Wernike Kerstin , Aebischer Andrea , Audonnet Jean-Christophe , Beer Martin 
Published: August 2022

Abstract
Background
Subsequent to its first detection in 2011, the insect-transmitted bunyavirus Schmallenberg virus (SBV; genus Orthobunyavirus) caused a large-scale epizootic of fetal malformation in the European ruminant population. By now, SBV established an enzootic status in Central Europe with regular wave-like re-emergence, which has prompted intensive research efforts in order to elucidate the pathogenesis and to develop countermeasures. Since different orthobunyaviruses share a very similar structural organization, SBV has become an important model virus to study orthobunyaviruses in general and for the development of vaccines. In this review article, we summarize which vaccine formulations have been tested to prevent SBV infections in livestock animals.

Main
In a first step, inactivated SBV candidate vaccines were developed, which efficiently protected against an experimental SBV infection. Due to the inability to differentiate infected from vaccinated animals (= DIVA capability), a series of further approaches ranging from modified live, live-vectored, subunit and DNA-mediated vaccine delivery to multimeric antigen-presentation on scaffold particles was developed and evaluated. In short, it was repeatedly demonstrated that the N-terminal half of the glycoprotein Gc, composed of the Gc head and the head-stalk, is highly immunogenic, with a superior immunogenicity of the complete head-stalk domain compared to the Gc head only. Furthermore, in all Gc protein-based vaccine candidates, immunized animals can be readily discriminated from animals infected with the field virus by the absence of antibodies against the viral N-protein.

Conclusions
Using SBV as a model virus, several vaccination-challenge studies in target species underscored the superior performance of antigenic domains compared to linear epitopes regarding their immunogenicity. In addition, it could be shown that holistic approaches combining immunization-challenge infection studies with structural analyses provide essential knowledge required for an improved vaccine design.
Enhanced radiation characteristics of regular dodecagon split ring resonator (D-SRR)-based microstrip patch antenna employing dielectric superstrate for THz applications
Authors: Benkhallouk Kaddour , Bendaoudi Amina , Berka Mohammed , Mahdjoub Zoubir 
Published: August 2022

AbstractIn a world where communication requires ever faster data transmission capable of transmitting high speeds. In order to reach and transmit this high speed, it is necessary to increase the frequency that carries the information. For this, scientists are interested in the terahertz (THz) range which, thanks to its high frequencies between 0.1 THz and 30 THz, offers the possibility of increasing the data rate. This letter presents the inclusion of Dodecagon Split Ring Resonator (D-SRR) in rectangular microstrip patch antenna and its effect in the performance of the proposed antenna. The metamaterial design employs two types of SRRs resonators shapes such as the Dodecagon Broadside Coupled Split Ring Resonator (DBC-SRR) and Dodecagon Split Ring Resonator (D-SRR). The model applied uses a local field approach and allowed to obtain the dispersion characteristics of discrete negative magnetic permeability. The proposed antenna substrate uses Arlon AD1000 material, which helps to attain high gain and good directivity at THz frequency. The antenna performance is investigated with and without superstrate. The operating frequencies of the proposed antenna vary in the range of 0.66 - 0.69 THz and shows maximum gain of 10.4 dB and maximum directivity of 9.84 dB. HFSS software tool helps to simulate the parametric analysis of the proposed antenna design. This novel structure may find applications in terahertz imaging, remote systems and may find manifold possibilities in the medical field.
Unsupervised clustering of SARS-CoV-2 using deep convolutional autoencoder
Authors: Sherif Fayroz F. , Ahmed Khaled S. 
Published: August 2022

AbstractSARS-CoV-2’s population structure might have a substantial impact on public health management and diagnostics if it can be identified. It is critical to rapidly monitor and characterize their lineages circulating globally for a more accurate diagnosis, improved care, and faster treatment. For a clearer picture of the SARS-CoV-2 population structure, clustering the sequencing data is essential. Here, deep clustering techniques were used to automatically group 29,017 different strains of SARS-CoV-2 into clusters. We aim to identify the main clusters of SARS-CoV-2 population structure based on convolutional autoencoder (CAE) trained with numerical feature vectors mapped from coronavirus Spike peptide sequences. Our clustering findings revealed that there are six large SARS-CoV-2 population clusters (C1, C2, C3, C4, C5, C6). These clusters contained 43 unique lineages in which the 29,017 publicly accessible strains were dispersed. In all the resulting six clusters, the genetic distances within the same cluster (intra-cluster distances) are less than the distances between inter-clusters (P-value 0.0019, Wilcoxon rank-sum test). This indicates substantial evidence of a connection between the cluster’s lineages. Furthermore, comparisons of the K-means and hierarchical clustering methods have been examined against the proposed deep learning clustering method. The intra-cluster genetic distances of the proposed method were smaller than those of K-means alone and hierarchical clustering methods. We used T-distributed stochastic-neighbor embedding (t-SNE) to show the outcomes of the deep learning clustering. The strains were isolated correctly between clusters in the t-SNE plot. Our results showed that the (C5) cluster exclusively includes Gamma lineage (P.1) only, suggesting that strains of P.1 in C5 are more diversified than those in the other clusters. Our study indicates that the genetic similarity between strains in the same cluster enables a better understanding of the major features of the unknown population lineages when compared to some of the more prevalent viral isolates. This information helps researchers figure out how the virus changed over time and spread to people all over the world.
Approach to the Patient on Antihypertensive Therapy: Screen for Primary Aldosteronism
Authors: Mulatero Paolo , Bertello Chiara , Veglio Franco , Monticone Silvia 
Published: August 2022

Abstract
Primary aldosteronism (PA) is a condition that is still largely overlooked, resulting in a considerable burden of mortality and morbidity. This is despite decades of clinical and translational research on the deleterious effects of aldosterone on the cardiovascular system and the publication of several guidelines and consensuses on its diagnosis and treatment. One of the main reasons for the low rate of testing is the difficulty of screening patients on antihypertensive therapy that potentially interferes with aldosterone and renin levels and thus confound the interpretation of the aldosterone to renin ratio, the accepted and conventionally used screening test. To avoid interference, usually the therapies that affect the renin-angiotensin aldosterone system are withdrawn and substituted with noninterfering medications. However, in many cases the screening test can be confidently interpreted even when such therapies are not discontinued. In this review, we will evaluate the effects of antihypertensive therapies on the screening test for PA and suggest a practical approach for its interpretation.
Effects of punctate skin grafting combined with or without irrigation on skin graft survival, redness and swelling score and pain in treatment of large-area residual burn wounds
Authors: Wan Lei , Zhou Jin , Li Linjie 
Published: August 2022

Objective: To investigate the effects of punctate skin grafting combined with or without irrigation on skin graft survival, redness and swelling score and pain in the treatment of large-area residual burn wounds.
Methods: A prospective study was conducted on 102 patients with large-area burns treated in Huangshi Central Hospital from May 2017 to May 2020. According to different treatment methods, they were divided into combination group (treated with punctate skin grafting combined with irrigation) and grafting group (mainly treated with punctate skin grafting). The positive rate of bacterial culture of wound secretions, pain score and redness and swelling score were analyzed and compared between the two groups. Additionally, linear logistic analysis of the influencing factors was carried out.
Results: The positive rate of bacterial culture of wound secretions decreased to 29.4% in the combination group and 49.0% in the grafting group (p< 0.05). The skin graft survival rate of the combination group was (82.17 ± 7.44) %, which was higher than that of the grafting group (61.53 ± 7.46) %, the wound healing time was (14.56 ± 3.51) d, which was shorter than that of the grafting group (21.36 ± 4.69) d, and the pain score (3.26 ± 0.36) and redness and swelling score (1.16 ± 0.68) were lower than those of the grafting group (4.79± 0.46) and (2.56 ± 0.85), respectively (all p< 0.05). The wound healing time was positively correlated with pain score (r = 0.767, p< 0.05) and redness and swelling score (r = 0.672, p< 0.05), while negatively correlated with skin graft survival rate (r= -0.289, P<0.01), meeting linear equation y = -8.451 + 4.542a + 0.087b + 1.012c (a, pain score; b, skin graft survival rate; c, redness and swelling score).
Conclusions: Punctate skin grafting combined with irrigation in the treatment of large-area residual burn wounds presents great effects on skin graft survival, redness and swelling score and pain, and is worthy of clinical application and promotion.
doi: https://doi.org/10.12669/pjms.38.7.5522
How to cite this:Wan L, Zhou J, Li L. Effects of punctate skin grafting combined with or without irrigation on skin graft survival, redness and swelling score and pain in treatment of large-area residual burn wounds. Pak J Med Sci. 2022;38(7):---------. doi: https://doi.org/10.12669/pjms.38.7.5522
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Clinical and bacteriological outcomes in patients with urinary tract infections presenting to primary care in Harare, Zimbabwe: a cohort study
Authors: Olaru Ioana D. , Chisenga Mutsawashe , Yeung Shunmay , Chonzi Prosper , Masunda Kudzai P.E. , Ferrand Rashida A. , Kranzer Katharina 
Published: August 2022

Background: Treatment for urinary tract infections (UTIs) is usually empiric and is based on local antimicrobial resistance data. These data, however, are scarce in low-resource settings. The aim of this study is to determine the impact of antibiotic treatment on clinical and bacteriological outcomes in patients presenting with UTI symptoms to primary care in Harare. Methods: This cohort study enrolled participants presenting with UTI symptoms to 10 primary healthcare clinics in Harare between July 2019 and July 2020. A questionnaire was administered and a urine sample was collected for culture. If the urine culture showed growth of ≥105 colony forming units/mL of a uropathogen, a follow up visit at 7-21 days was conducted. Results: The analysis included 168 participants with a median age of 33.6 years (IQR 25.1-51.4) and of whom 131/168 (78.0%) were female. Effective treatment was taken by 54/168 (32.1%) participants. The urine culture was negative at follow up in 41/54 (75.9%) of participants who took appropriate treatment and in 33/114 (28.9%, p<0.001) of those who did not. Symptoms had improved or resolved in 52/54 (96.3%) of those on appropriate treatment and in 71/114 (62.3%, p<0.001) of those without. Conclusion: The findings of this study show that effective treatment leads to symptom resolution and bacterial clearance in people presenting with UTIs to primary care. Although UTIs are not life-threatening and can resolve without treatment, they do impact on quality of life, highlighting the need for optimised treatment recommendations.