bluuebunny/crossref_metadata_2025_split huggingface dataset:
Malignant Ocular Melanoma with Intradural Cervical Metastasis: Case Report and Literature Review
Authors: Mazzo Felipe Antonio Torres , De Lucca Maria Eduarda Turczyn , Alencar Guilherme dos Santos de , Munhos Sue Hellen de Oliveira , Jaouhari Eduardo Talib Bacchi , Morais Rodrigo Leite de , Barcelos Carlos Eliseu , Torres Rosângela Stadnick Lauth de Almeida 
Published: September 2022

Abstract
Introduction The occurrence of malignant ocular melanomas is uncommon, and the association of these tumors with intradural extramedullary metastases in the cervical spine is exceptionally rare.
Case Report A 62-year-old woman undergoing adjuvant chemotherapy after surgical treatment for malignant ocular melanoma begins to experience vertigo and headache. The condition evolved with walking difficulty and neck pain that was exacerbated by swallowing and mobilizing the neck. During her ocular melanoma follow-up, lesions suggestive of metastasis in the central nervous system were not evidenced until this moment. The physical examination did not show significant findings, and a cranial computed tomography scan was performed. The image showed a hyperdense lesion with postcontrast enhancement inside the vertebral canal, at the level of C1-C2. Spinal decompression and subtotal resection were performed. The anatomopathological report revealed intradural metastasis of a malignant ocular melanoma. The postoperative period was uneventful, with significant pain improvement and no recurrences.
Conclusion Intradural extramedullary metastases are rare presentations of malignant ocular melanoma. In addition, less than ten similar cases have been reported in the literature. When caring for a patient with melanoma and neurological deficits, always consider evaluating central nervous system metastases. To evaluate this patient, a sensible and detailed neurological exam is extremely important to recognize the location of the deficits and guide the best approach, such as an indication for surgery.
Current Management of Heart Failure with Preserved Ejection Fraction
Authors: Patel Akash H. , Natarajan Balaji , Pai Ramdas G. 
Published: September 2022

AbstractHeart failure with preserved ejection fraction (HFpEF) encompasses nearly half of heart failure (HF) worldwide, and still remains a poor prognostic indicator. It commonly coexists in patients with vascular disease and needs to be recognized and managed appropriately to reduce morbidity and mortality. Due to the heterogeneity of HFpEF as a disease process, targeted pharmacotherapy to this date has not shown a survival benefit among this population. This article serves as a comprehensive historical review focusing on the management of HFpEF by reviewing past, present, and future randomized controlled trials that attempt to uncover a therapeutic value. With a paradigm shift in the pathophysiology of HFpEF as an inflammatory, neurohormonal, and interstitial process, a phenotypic approach has increased in popularity focusing on the treatment of HFpEF as a systemic disease. This article also addresses common comorbidities associated with HFpEF as well as current and ongoing clinical trials looking to further elucidate such links.
Pathophysiology and Management of Pulmonary Embolism
Authors: Shah Ishan K. , Merfeld John M. , Chun Jimy , Tak Tahir 
Published: September 2022

AbstractPulmonary embolism (PE) is one of the most common etiologies of cardiovascular mortality. It could be linked to several risk factors including advanced age. The pathogenesis of PE is dictated by the Virchow's triad that includes venous stasis, endothelial injury, and a hypercoagulable state. The diagnosis of PE is difficult and is often missed due to the nonspecific symptomatology. Hypoxia is common in the setting of PE, and the degree of respiratory compromise is multifactorial and influenced by underlying cardiac function, clot location, and ability to compensate with respiratory mechanics. Right ventricular dysfunction/failure is the more profound cardiovascular impact of acute PE and occurs due to sudden increase in afterload. This is also the primary cause of death in PE. High clinical suspicion is required in those with risk factors and presenting signs or symptoms of venous thromboembolic disease, with validated clinical risk scores such as the Wells, Geneva, and pulmonary embolism rule out criteria in estimating the likelihood for PE. Advancement in capture time and wider availability of computed tomographic pulmonary angiography and D-dimer testing have further facilitated the rapid evaluation and diagnosis of suspected PE. Treatment is dependent on clinical presentation and initially involves providing adequate oxygenation and stabilizing hemodynamics. Anticoagulant therapy is indicated for the treatment of PE. Treatment is guided by presence or absence of shock and ranges from therapeutic anticoagulation to pharmacologic versus mechanical thrombectomy. The prognosis of patients can vary considerably depending on the cardiac and pulmonary status of patient and the size of the embolus.
Multidisciplinary Treatment of Persistent Nontuberculous Mycobacterial Spinal Hardware Infection with a Pedicled Superior Gluteal Artery Perforator Flap
Authors: Tuano Krystle R. , Yang Jerry H. , Kleck Christopher J. , Mathes David W. , Chong Tae W. 
Published: September 2022

AbstractNontuberculous mycobacterial hardware infections are extremely challenging to treat. Multidisciplinary care involving removal of infected hardware, thorough debridement, and durable soft tissue coverage in conjunction with antibiotic therapy is essential for successful management. This case report presents a patient with chronic mycobacterial spinal hardware infection that underwent successful treatment with aggressive serial debridements and reconstruction with a large pedicled superior gluteal artery perforator flap coverage.
Effects of Femoral Component Design on the Deepest Point Position of the Trochlear Grove in Kinematically Aligned Total Knee Arthroplasty: A Comparison of Four Prothesis Designs
Authors: Takashima Yoshinori , Nakano Naoki , Ishida Kazunari , Kamenaga Tomoyuki , Tsubosaka Masanori , Kuroda Yuichi , Hayashi Shinya , Kuroda Ryosuke , Matsumoto Tomoyuki 
Published: September 2022

AbstractThe aim of the study is to explore and compare the differences in trochlear shape and knee anatomy between four types of prostheses and preoperative native knee matched with preoperative computed tomography (CT). Thirty patients were scheduled for primary kinematically aligned total knee arthroplasty (TKA) for varus knee osteoarthritis at our hospital and the region between their pelvis to ankle joint was simulated using a CT-based three-dimensional planning software. The axial plane containing the transepicondylar axis was set as Slice A, and the 10-mm distal plane from Slice A was set as Slice B. The distances to the deepest trochlear groove between the native knee and each prosthesis and the medial and lateral facet heights were compared among the four groups. The deepest femoral trochlear groove of the prostheses was located 1.6 to 3.0 mm more medial than that of the native knee, and in the Persona group, it was significantly more medial than in the e-motion or Triathlon groups on both Slices A and B. The native knee and the medial and lateral facet heights of the four prostheses on both Slices A and B were significantly lower than those of preoperative native knees when femoral prostheses were set in the kinematically aligned (KA)-TKA position. The deepest point of the trochlear groove of the Persona group was the most medial among the four prostheses studied, and the deepest points differed depending on the prosthesis design in KA-TKA. Thus, surgeons should carefully select the type of prostheses used in KA-TKA.
COVID-19 confines recreational gatherings in Seoul to familiar, less crowded, and neighboring urban areas
Authors: Yoon Jisung , Jung Woo-Sung , Kim Hyunuk 
Published: September 2022

AbstractRecreational gatherings are sources of the spread of infectious diseases. Understanding the dynamics of recreational gatherings is essential to building effective public health policies but challenging as the interaction between people and recreational places is complex. Recreational activities are concentrated in a set of urban areas and establish a recreational hierarchy. In this hierarchy, higher-level regions attract more people than lower-level regions for recreational purposes. Here, using customers’ motel booking records which are highly associated with recreational activities in Korea, we identify that recreational hierarchy, geographical distance, and attachment to a location are crucial factors of recreational gatherings in Seoul, Republic of Korea. Our analyses show that after the COVID-19 outbreak, people are more likely to visit familiar recreational places, avoid the highest level of the recreational hierarchy, and travel close distances. Interestingly, the recreational visitations were reduced not only in the highest but also in low-level regions. Urban areas at low levels of the recreational hierarchy were more severely affected by COVID-19 than urban areas at high and middle levels of the recreational hierarchy.
Protective effects of pre-treatment with exogenous porcine glucagon-like peptide-2 and its microspheres of piglets with lipopolysaccharide-induced intestinal inflammation
Authors: Wu Jie , Qi Keke , Xu Ziwei 
Published: September 2022

Context Glucagon-like peptide-2 (GLP-2) is an intestinotrophic growth hormone that can accelerate intestinal development and recovery from injury. However, the half-life of GLP-2 is short, thus it must be administered frequently. Moreover, its effects during weaning are unclear. Aims We tested the effects of porcine GLP-2 (pGLP-2) and pGLP-2 microspheres on lipopolysaccharide (LPS)-induced intestinal inflammation in weaning piglets. Methods Eighteen female weaning piglets aged 21 days (5.38 ± 0.72 kg initial bodyweight) were randomly assigned to three treatment groups: (1) control, (2) GLP-2, and (3) GLP-2 microsphere (MS) group. Control piglets were injected intraperitoneally with 3 mL of saline solution from Days 1 to 7, GLP-2 piglets were injected intraperitoneally with 100 μg pGLP-2/kg bodyweight from Days 1 to 7, and MS piglets were injected intraperitoneally with 200 mg GLP-2 microspheres on Day 1 and with 3 mL saline solution from Days 2 to 7. On Day 8, all piglets were injected with 100 μg LPS/kg bodyweight. Key results Piglets in the GLP-2 and MS groups showed markedly increased average daily weight gain on Day 7, decreased serum myeloperoxidase, LPS and keratinocyte growth factor levels, and increased serum interleukin-10 levels compared with the control group. In addition, the GLP-2 group showed decreased myeloperoxidase content in the duodenum and ileum, and reduced caspase-3 activity in the duodenum and jejunum, whereas MS piglets showed decreased myeloperoxidase levels and suppressed caspase-3 activity in the duodenum and jejunum. Moreover, administration of pGLP-2 or pGLP-2 microspheres resulted in decreased interleukin-8 and interferon-γ mRNA expression levels in the jejunum, as compared with the control group. Conclusions Our results indicated that pGLP-2 promotes growth, and ameliorates LPS-induced serum and intestinal inflammatory responses in piglets. Furthermore, pGLP-2 microspheres can achieve similar therapeutic effects as pGLP-2 under the premise of fewer injections. Implications pGLP-2 microspheres have considerable potential for the treatment of weaning-induced intestinal inflammation in piglets.
Report on comparison EURAMET.M.M-S10 (comparison of sub-multiples of the kilogram)
Authors: Grgić G , Bošković Begenišić T , Bezjak M , Ališić Š , Bulku D , Snopko L 
Published: September 2022

Main text
In order to demonstrate the equivalence in calibration of sub-multiples of the kilogram (200 g, 20 g, 2g, 200 mg), a supplementary comparison has been carried out by 6 members of EURAMET. The overall result shows a good agreement among participants with two discrepant results at 200 g and one for 2 g.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Additive manufactured cardiovascular scaffold integrated with SU-8 based wireless pressure sensor
Authors: Sun Gang-hyeon , Kim Dong-Su , Shanmugasundaram Arunkumar , Lee Dong-Weon 
Published: September 2022

Abstract
Herein, we proposed a SU-8 based wireless pressure sensor integrated with a polycaprolactone (PCL) based bioresorbable scaffold (BRS) for the detection of biological cues. The PCL-based BRS and pressure sensor are fabricated using a custom-designed additive manufacturing method and a modified photolithography technique. Firstly, we optimized the additive manufacturing fabrication parameters to realize the highly reliable scaffold with uniform strut width and thickness. Then, utilizing the optimized additive manufacturing conditions, we fabricated three distinct types of scaffolds, namely scaffold A, scaffold B, and scaffold C, each with a unique architecture. The preliminary characteristics of the fabricated scaffolds demonstrated that the scaffold A architecture exhibited superior properties, including 0.048 N mm−1 radial force, 1.64% foreshortening, and 14.1% recoil compared to the scaffolds B and C. The Inductor-Capacitor (LC)-pressure sensor is integrated into the PCL-based BRS using a water-soluble polyvinyl alcohol adhesive layer. The reliability of the fabricated LC-pressure sensor is confirmed by measuring its change capacitance and resonance frequency at different applied pressures. The proposed LC-pressure sensor integrated PCL-based BRS is evaluated in a pressure range of 0–280 mmHg. The resonant frequency of the fabricated smart scaffold changed linearly according to the pressure change indicating the high reliability of the proposed smart scaffold. We anticipate that the proposed pressure sensor integrated with the biodegradable PCL-based BRS would be used for biomedical applications owing to their facile fabrication process and excellent sensitivity.
Accurate predictions from small boxes: variance suppression via the Zel'dovich approximation
Authors: Kokron Nickolas , Chen Shi-Fan , White Martin , DeRose Joseph , Maus Mark 
Published: September 2022

AbstractSimulations have become an indispensable tool for accurate modelling of observables measured in galaxy surveys, but can be expensive if very large dynamic range in scale is required. We describe how to combine Lagrangian perturbation theory models with N-body simulations to reduce the effects of finite computational volume in the prediction of ensemble average properties in the simulations within the context of control variates. In particular we use the fact that Zel'dovich displacements, computed during initial condition generation for any simulation, correlate strongly with the final density field. Since all the correlators of biased tracers can be computed with arbitrary precision for these displacements, pairing the Zel'dovich `simulation' with the N-body realization allows hundredfold reductions in sample variance for power spectrum or correlation function estimation. Zel'dovich control variates can accurately extend matter or tracer field emulators to larger scales than previously possible, as well as improving measurements of statistics in simulations which are inherently limited to small volumes, such as hydrodynamical simulations of galaxy formation and reionization.
Anisotropicity and flexibility in trilayered microfibrous substrates promote heart valve leaflet tissue engineering
Authors: Snyder Yuriy , Jana Soumen 
Published: September 2022

Abstract
Heart valve leaflet substrates with native trilayer and anisotropic structures are crucial for successful heart valve tissue engineering. In this study, we used the electrospinning technique to produce trilayer microfibrous leaflet substrates using two biocompatible and biodegradable polymers—poly (L-lactic acid) (PLLA) and polycaprolactone (PCL), separately. Different polymer concentrations for each layer were applied to bring a high degree of mechanical and structural anisotropy to the substrates. PCL leaflet substrates exhibited lower unidirectional tensile properties than PLLA leaflet substrates. However, the PLLA substrates exhibited a lower flexural modulus than the PCL substrates. These substrates were seeded with porcine valvular interstitial cells (PVICs) and cultured for one month in static conditions. Both substrates exhibited cellular adhesion and proliferation, resulting in the production of tissue-engineered constructs. The PLLA tissue-engineered constructs had more cellular growth than the PCL tissue-engineered constructs. The PLLA substrates showed higher hydrophilicity, lower crystallinity, and more significant anisotropy than PCL substrates, which may have enhanced their interactions with PVICs. Analysis of gene expression showed higher α-smooth muscle actin and collagen type 1 expression in PLLA tissue-engineered constructs than in PCL tissue-engineered constructs. The differences in anisotropic and flexural properties may have accounted for the different cellular behaviors in these two individual polymer substrates.
The Design of Ship Operation Cost Estimation Simulator Uses a Case Study of The Bung Tomo Trainer Ship
Authors: Widyaningsih U , Sutoyo  , Yuda A A N P , Mirianto A , Zuhri Z , Harini N V 
Published: September 2022

Abstract
Calculation of ship operating costs is the main element in determining tariffs, since determining the high and low rates is very important in the shipping business. In other words, determining the right ship operating costs is the key to the success of the shipping business. Vessel operating costs are determined by direct and indirect operational costs. Direct operational costs include capital costs, insurance costs, insurance premiums, crew costs, fuel costs, lubricant costs, grease costs, fresh water costs, port costs and Repair, Maintenance, Supply (RMS) costs. The indirect operational costs include branch office costs and admin costs. Calculation of ship operating costs can actually be done manually, but it will take a lot of time. So, we need a way to calculate the operational costs of ships that are easy and efficient. In this study we developed an application to calculate ship operating costs. Then we call this application a simulator. From the simulations carried out, the results obtained that the results of calculations using the simulator are the same as the results of manual calculations, namely the total cost in rupiah. The advantage of this simulator is that it saves calculation time, so that the results obtained are easier and more efficient. In addition, the appearance of the simulator is very good in accordance with the demands of the digitalization of sea transportation and this simulator can be used by all groups because it is easy to operate.
Illegal, Unreported and Unregulated (IUU) Fishing in Indonesia: Problems and Solutions
Authors: Leonardo Adam , Deeb Nowar 
Published: September 2022

Abstract
Illegal, unreported, and unregulated (IUU) fishing is one of seven major threats to global maritime security listed by the United Nations. IUU fishing can be caused by economic factors, social factors, institutional factors, and organized IUU fishing operations. This review article discusses the topic of IUU fishing in Indonesia, as well as remedies to the problem that have been previously investigated and potentially can be applied in Indonesia. IUU fishing can result in economic losses, environmental degradation, and economic loss for coastal communities, as well as a reduction in fish stocks. Indonesia has vast marine resources, and making better use of them can boost the country’s economic progress. IUU fishing is still happening in Indonesia and it caused an economic loss. According to reports, IUU fishing caused Indonesia to lose up to IDR 101 trillion annually. Therefore, appropriate strategies are needed. For this reason, the government has given IUU fishing a high priority for resolution. As it is critical to resolving the IUU fishing issue. It can be inferred that, in terms of combating IUU fishing, there are three critical aspects to consider. They are law and regulation, social and government cooperation, and technology investment, especially in monitoring, control, and surveillance.
Form Factor Prediction Based on Ship Model Test Data by Statistical Method
Authors: Widodo  , Santoso Agoes , Erwandi  , Baidowi Achmad 
Published: September 2022

Abstract
The ship model resistance test is carried out on the towing tank with a certain scale to get the total resistance coefficient of the ship model. The value of the ship’s form factor is needed in extrapolation calculations to get the coefficient and total resistance value of a full-scale ship. The form factor can be obtained using the traditional method, namely testing the resistance of the ship model with a Froude Number between 0.1 – 0.2. This method is known as the Prohaska method. Another method or a more modern method is to use multiple linear regression statistics based on the ship model test. We used data from 41 displacement ship model tests conducted at the Hydrodynamics Technology Laboratory (LTH)-National Agency for Research & Innovation (BRIN). Data processing is done through statistical software using the OLS or Robust method which was previously done by transforming predictor variables to enlarge the variety of variables so that a good regression equation is obtained. The resulting form factor regression is a useful tool for predicting the ship’s Effective Power value.
The effect of safety climate on safety behavior with intervention
Authors: Pradeti Rahajeng , Widiarti Yuning , Santiasih Indri 
Published: September 2022

Abstract
Safety climate influences safety behavior and tends to unsafe behavior. Accidents caused by unsafe behavior are quite high, 80%-85% than unsafe conditions. Previous research has addressed the safety climate to safety behavior by looking at the impact and involvement of individuals and the result is controlled safety climate to increase in safety behavior. Changes in unsafe behavior need to be made by applying intervention methods. Based on this, research is carried out on the influence of safety climate on safety behavior by providing interventions to change behavior. The study was conducted on 198 production workers in manufacturing companies. The safety climate influence analysis was conducted using the NOSACQ-50 questionnaire and multivariate linear regression test, Structural Equation Model (SEM) to see who influenced worker behavior and T-Paired test to see results of the given intervention. Implementation of behavior change is done by intervention. Intervention is provided by installing special safety signs at work and training for workers. The results of the intervention were analyzed using the Critical Behavior Checklist (CBC). The results of the influence test showed that management had a large influence on worker behavior with 5 variables. Testing with SEM showed that there were 3 variables with significant values so that worker behavior was influenced by management opinions and attitudes. The T-Paired test showed that unsafe behavior decreased and safe behavior increased after the intervention was administered. Thus, management has a considerable influence on the formation of worker behavior so management needs to participate in realizing work safety.