bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gradual relation between perceptual awareness, recognition and pupillary responses to social threat
Authors: Poyo Solanas Marta , Zhan Minye , de Gelder Beatrice 
Published: September 2022

AbstractThere is substantial evidence about affective stimulus processing outside awareness in healthy participants and brain-damaged patients. However, there are still methodological concerns mainly relating to the methods used to assess awareness. In two experiments, we investigated the processing of social threat in healthy participants by combining the continuous flash suppression paradigm and the perceptual awareness scale, a finer measure of perceptual awareness than dichotomous (seen/unseen) responses. Our behavioral results show a gradual relationship between emotional recognition and perceptual awareness. Recognition sensitivity was also higher for fearful than angry bodies for all visual awareness levels except for the perceptual unawareness condition where performance was at chance level. Interestingly, angry body expressions were suppressed for a shorter duration than neutral and fearful ones. Pupil dilation was a function of affective expression, the duration of suppression and the level of perceptual awareness. In conclusion, behavioral as well as pupillary responses showed a gradual relationship with perceptual awareness, and this relationship was influenced by the specific stimulus category.
Pre- and post-task resting-state differs in clinical populations
Authors: Lor Cindy Sumaly , Zhang Mengfan , Karner Alexander , Steyrl David , Sladky Ronald , Scharnowski Frank , Haugg Amelie 
Published: September 2022

AbstractResting-state functional connectivity has generated great hopes as a potential brain biomarker for improving prevention, diagnosis, and treatment in psychiatry. This neuroimaging protocol can routinely be performed by patients and does not depend on the specificities of a task. Thus, it seems ideal for big data approaches that require aggregating data across multiple studies and sites. However, technical variability, diverging data analysis approaches, and differences in data acquisition protocols might introduce heterogeneity to the aggregated data. Besides these technical aspects, the psychological state of participants might also contribute to heterogeneity. In healthy participants, studies have shown that behavioral tasks can influence resting-state measures, but such effects have not yet been reported in clinical populations. Here, we fill this knowledge gap by comparing resting-state functional connectivity before and after clinically relevant tasks in two clinical conditions, namely substance use disorders and phobias. The tasks consisted of viewing craving-inducing and spider anxiety provoking pictures that are frequently used in cue-reactivity studies and exposure therapy. We found distinct pre- vs. post-task resting-state connectivity differences in each group, as well as decreased thalamo-cortical and increased intra-thalamic connectivity which might be associated with decreased vigilance in both groups. Notably, the pre- vs. post-task thalamus-amygdala connectivity change within a patient cohort seems more pronounced than the difference of that connection between the smoker vs. phobia clinical trait. Our results confirm that resting-state measures can be strongly influenced by changes in psychological states that need to be taken into account when pooling resting-state scans for clinical biomarker detection. This demands that resting-state datasets should include a complete description of the experimental design, especially when a task preceded data collection.
Controlled Human Malaria Infection reveals that the Dantu blood group variant provides high level protection against uncomplicated malaria
Authors: Kariuki Silvia N , Macharia Alexander W , Makale Johnstone , Nyamu Wilfred , Hoffman Stephen L , Kapulu Melissa C , Bejon Philip , Rayner Julian C , Williams Thomas N ,   the CHMI-SIKA Study Team
Published: September 2022

AbstractIntroductionThe long co-evolution ofHomo sapiensandPlasmodium falciparumhas resulted in the selection of numerous human genetic variants that confer an advantage against severe malaria and death. One such variant is the Dantu blood group antigen, which is associated with 74% protection against severe and complicatedP. falciparummalaria infections in homozygous individuals, similar to that provided by the sickle haemoglobin allele (HbS). Recentin vitrostudies suggest that Dantu exerts this protection by increasing the surface tension of red blood cells, thereby impeding the ability ofP. falciparummerozoites to invade them and reducing parasite multiplication. However, no studies have yet explored this hypothesisin vivo.MethodsWe investigated the effect of Dantu on early phaseP. falciparum(Pf) infections in a controlled human malaria infection (CHMI) study. 141 sickle negative Kenyan adults were inoculated with 3.2×103aseptic, purified, cryopreserved Pf sporozoites (PfSPZ Challenge) then monitored for blood-stage parasitaemia for 21 days by quantitative polymerase chain reaction (qPCR) analysis of the 18S ribosomal RNAP. falciparumgene. The primary endpoint was blood-stageP. falciparumparasitaemia of ≥500/μl while the secondary endpoint was the receipt of antimalarial treatment in the presence of parasitaemia of any density. On study completion, all participants were genotyped both for Dantu and for four other polymorphisms that are associated with protection against severe falciparum malaria: α+-thalassaemia, blood group O, G6PD deficiency, and the rs4951074 allele in the red cell calcium transporterATP2B4.ResultsThe primary endpoint was reached in 25/111 (22.5%) non-Dantu subjects, in comparison to 0/27 (0%) Dantu heterozygotes and 0/3 (0.0%) Dantu homozygotes (p=0.01). Similarly, 49/111 (44.1%) non-Dantu subjects reached the secondary endpoint in comparison to only 7/27 (25.9%) and none of the 3 (0.0%) Dantu heterozygotes and homozygotes respectively (P=0.021). No significant impacts on either outcome were seen for any of the other variants under study.ConclusionThis study reveals, for the first time, that the Dantu blood group is associated with high level protection against early, non-clinical,P. falciparummalaria infectionsin vivo. Learning more about the mechanisms involved could potentially lead to new approaches to the prevention or treatment of the disease. Our study illustrates the power of CHMI with PfSPZ Challenge for directly testing the protective impact of genotypes previously identified using other methods.
To start or to discontinue the pill – changes in progestogens reflected by resting-state connectivity and positive mood
Authors: Kimmig A-C.S. , Friedrich P. , Drotleff B. , Lämmerhofer M. , Sundström-Poromaa I. , Weis S. , Derntl B. 
Published: September 2022

AbstractOral contraceptive (OC) intake has been associated with alterations in functional brain architecture and socio-affective processes. However, most previous studies have been limited by cross-sectional designs and/or did not account for synthetic sex hormone concentrations. The aim of this longitudinal study was to determine the effects of starting vs discontinuing OCs on socio-affective functions such as mood and emotion cognition, and to identify their possible neuroendocrinological substrates.To this end, 88 young healthy women performed the behavioral and fMRI measures twice, three to eight months apart: 26 natural cycling women twice during menstruation, 26 OC users twice during OC intake, 25 OC discontinuers and 11 OC starters before and after discontinuation or start, respectively. In addition to mean-based analyses, we used intersubject representational similarity analyses to determine relationships between interindividual variability in within-subject changes of hormone profiles, including concentrations of endogenous and synthetic hormones, region-specific resting state functional connectivity (parcelwise RSFC) and socio-affective measures.Across the whole sample, interindividual patterns of changes in RSFC of fronto-parietal regions, parts of the left hippocampus and the right cerebellum reflected change patterns of progestogen levels. For the right superior orbitofrontal gyrus (OFG), a trinity of idiosyncratic patterns was found in changes of progestogens, RSFC and positive mood. Active OC intake was associated with higher self-reported depressive symptoms in OC discontinuers (and starters). Emotion recognition performance was not associated with changes in hormone profiles or RSFC.Overall, progestogens rather than estrogens appear to be associated with functional brain architecture of the frontal and subcortical/cerebellar regions and positive mood. The right superior OFG represents a possible neural substrate for progestogen-induced changes in positive mood. This study indicates the importance of a multidimensional, longitudinal approach when being interested in effects of hormonal contraception on women’s brain and behavior.
The Interaction of Context Constraints and Predictive Validity during Sentence Reading
Authors: Terporten René , Huizeling Eleanor , Heidlmayr Karin , Hagoort Peter , Kösem Anne 
Published: September 2022

ABSTRACTWords are not processed in isolation, instead they are commonly embedded in phrases and sentences. The sentential context influences the perception and processing of a word. However, how this is achieved by brain processes and whether predictive mechanisms underlie this process remains a debated topic. To this end we employed an experimental paradigm in which we orthogonalized sentence context constraints and predictive validity, which was defined as the ratio of congruent to incongruent sentence endings within the experiment. While recording electroencephalography, participants read sentences with three levels of sentential context constraints (high, medium and low). Participants were also separated into two groups, which differed in their ratio of valid congruent to incongruent target words that could be predicted from the sentential context. For both groups we investigated modulations of alpha power before, and N400 amplitude modulations after target word onset. The results reveal that the N400 amplitude gradually decreases with higher context constraints. Contrary, alpha power is non-monotonically influenced, displaying the strongest decrease for high context constraints over frontal electrode sites, while alpha power between medium and low context constraints does not differ. This indicates that both neural correlates are influenced by the degree of context constraint but are not affected by changes in predictive validity. The results therefore suggest that both N400 and alpha power are not unequivocally linked to the predictability of a target word based on larger contextual information.
Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches
Authors: Lo Emily Kwun Kwan , Wang Xiuwan , Lee Pui-Kei , Wong Ho-Ching , Lee Jetty Chung-Yung , Gómez-Gallego Carlos , Zhao Danyue , El-Nezami Hani , Li Jun 
Published: September 2022

AbstractZearalenone (ZEA), a secondary metabolite ofFusariumfungi found in cereal-based foods, promotes the growth of colon, breast, and prostate cancer cellsin vitro. However, the lack of animal studies hinders a deeper mechanistic understanding of the cancer-promoting effects of ZEA. This study aimed to determine the effect of ZEA on colon cancer progression and its underlying mechanisms. Through integrative analyses of transcriptomics, metabolomics, metagenomics, and host phenotypes, we investigated the impact of a 4-week ZEA intervention on colorectal cancer in xenograft mice. Our results showed a twofold increase in tumor weight with the 4-week ZEA intervention. ZEA exposure significantly increased the mRNA and protein levels of BEST4, DGKB, and Ki67 and the phosphorylation levels of ERK1/2 and AKT. Serum metabolomic analysis revealed that the levels of amino acids, including histidine, arginine, citrulline, and glycine, decreased significantly in the ZEA group. Furthermore, ZEA lowered the alpha diversity of the gut microbiota and reduced the abundance of nine genera, includingTuzzerellaandRikenella. Further association analysis indicated thatTuzzerellawas negatively associated with the expression of BEST4 and DGKB genes, serum uric acid levels, and tumor weight. Additionally, circulatory hippuric acid levels positively correlated with tumor weight and the expression of oncogenic genes, including ROBO3, JAK3, and BEST4. Altogether, our results indicated that ZEA promotes colon cancer progression by enhancing the BEST4/AKT/ERK1/2 pathway, lowering circulatory amino acid concentrations, altering gut microbiota composition, and suppressing short chain fatty acids production.
Predicting gene and protein expression levels from DNA and protein sequences with Perceiver
Authors: Stefanini Matteo , Lovino Marta , Cucchiara Rita , Ficarra Elisa 
Published: September 2022

AbstractBackground and ObjectiveThe functions of an organism and its biological processes result from the expression of genes and proteins. Therefore quantifying and predicting mRNA and protein levels is a crucial aspect of scientific research. Concerning the prediction of mRNA levels, the available approaches use the sequence straddling the Transcription Start Site (TSS) as input to neural networks. The State-of-the-art models (e.g., Xpresso and Basenjii) predict mRNA levels exploiting Convolutional (CNN) or Long Short Term Memory (LSTM) Networks. However, CNN prediction depends on convolutional kernel size, and LSTM suffers from capturing long-range dependencies in the sequence. Concerning the prediction of protein levels, as far as we know, there is no model for predicting protein levels by exploiting the gene or protein sequences.MethodsHere, we exploit a new model type (called Perceiver) for mRNA and protein level prediction, exploiting a Transformer-based architecture with an attention module to attend to long-range interactions in the sequences. In addition, the Perceiver model overcomes the quadratic complexity of the standard Transformer architectures. This work’s contributions are 1. DNAPerceiver model to predict mRNA levels from the sequence straddling the TSS; 2. ProteinPerceiver model to predict protein levels from the protein sequence; 3. Protein&DNAPerceiver model to predict protein levels from TSS-straddling and protein sequences.ResultsThe models are evaluated on cell lines, mice, glioblastoma, and lung cancer tissues. The results show the effectiveness of the Perceiver-type models in predicting mRNA and protein levels.ConclusionsThis paper presents a Perceiver architecture for mRNA and protein level prediction. In the future, inserting regulatory and epigenetic information into the model could improve mRNA and protein level predictions. The source code is freely available athttps://github.com/MatteoStefanini/DNAPerceiverGraphical AbstractHighlightsPredicting mRNA and protein levels from DNA and protein sequences is crucial in clinical applications.A transformer-based architecture with asymmetric attention (Perceiver) is exploited for mRNA and protein level prediction.The Perceiver architecture attends to longer range interactions compared to Transformer, CNN, and LSTM.The proposed model achieves state-of-the-art performance for mRNA level prediction.To the best of our knowledge, the protein level prediction task is addressed.The proposed model is tested on glioblastoma and lung cancer tissues.
COVID-19 two years on: a review of COVID-19-related empirical research in major tourism and hospitality journals
Authors: Huang Songshan (Sam) , Wang Xuequn 
Published: September 2022

Purpose
This study aims to provide a timely review of the COVID-19-related empirical research published in 19 quartile one (Q1) and quartile two (Q2) tourism and hospitality journals in social science citation index (SSCI).

Design/methodology/approach
A total of 407 COVID-19-related empirical papers were collected from the 19 SSCI Q1 and Q2 tourism and hospitality journals via Scopus database. Thematic content analysis was supplemented with Leximancer software to identify the research themes/subthemes, research methods and countries/regions of research.

Findings
The study found studies of COVID-19’s impact on consumer behaviour predominate in number, followed by studies on response actions and recovery strategies, impact on industry or sectors and impact on workers and employees. Based on the research themes identified, a knowledge mapping framework was produced. Over 70% of the studies used quantitative methods with quantitative survey as the dominant method of data collection. The USA and China were found to be the most studied countries.

Research limitations/implications
The study reviewed empirical research papers until January 2022 and covered most of the COVID-19-related empirical works in the field. An overview of the current state of COVID-19-related empirical research was provided with some critical discussions and suggestions for future research topics.

Originality/value
The findings give researchers a clear index for the current state of the art of COVID-19 research in hospitality and tourism. The paper provides practical implications for industry practitioners to retrieve relevant knowledge from the recent COVID-19-related literature in tourism and hospitality in coping with practical challenges brought by the COVID-19 pandemic.
Women in mining: from subtle barriers to open prejudice
Authors: Valadares Sabrina Silva , De Carvalho Neto Antonio Moreira , Mota-Santos Carolina Mota , Diniz Daniela Martins 
Published: September 2022

PurposeThe core of this study is women in mining. The aim of this study was to analyze the perception of women, about their work environment, their career, the human resources policies and practices and the work–family balance in the context of a multinational organization in the sector.Design/methodology/approachThe case study was carried through semi-structured interviews with 27 women who work in this organization.FindingsAlthough women report that they are capable of exercising any position/function in the company, they perceive wage gap in the investigated organization; that maternity leave and the fact of having children impact their career and their rise to higher positions in the organizational hierarchy negatively; situations of prejudice and discrimination experienced at work. Sometimes subtly, sometimes not so subtly, but they still constitute barriers faced by women in mining.Originality/valueAlthough the debate around the issue of gender inequality in organizations is not recent, little has been produced about the working condition of women in occupational fields where male domination is strong, such as mining.
“The old order Changeth!” Building sustainable knowledge management post COVID-19 pandemic
Authors: Dutta Debolina , Vedak Chaitali , Sawant Harshal 
Published: September 2022

PurposeThe global pandemic and the resulting rapid and large-scale digitization changed the way firms recognized and understood knowledge curation and management. The changing nature of work and work systems necessitated changes in knowledge management (KM), some of which are likely to have a long-term impact. Using the lens of technology in practice, the purpose of this study is to examine the impact of technology agency on KM structures and practices that evolved across five knowledge-intensive global organizations. This study then argues that sustainable knowledge management (SKM) systems evolve in specific contexts.Design/methodology/approachThis study adopts a qualitative case study design to examine five multinational knowledge-intensive global organizations’ KM systems and practices across diverse industry sectors.FindingsBased on the findings, the authors develop SKM systems and practices model relevant to a post-pandemic organizational context. The authors argue that KM digitization and adoption support socialization in knowledge sharing. Further formalization through organizational enabling systems aids the externalization of knowledge sharing. Deliberate practices promoted with leadership support are likely to sustain in the post-COVID era. Further, organizations that evolvedad-hocor idiosyncratic approaches to managing hybrid working are more likely to revert to legacy KM systems. The authors eventually theorize about the socialization of human-to-human and technology-mediated human interactions and develop the three emerging SKM structures.Originality/valueThis study contributed to practitioners and researchers by developing the various tenets of SKM.
Punching shear capacity of flat slabs with recycled aggregate
Authors: Farahat Amal A. , Elansary Ahmed A. , Abdalla Hany A. 
Published: September 2022

Purpose
Punching can trigger catastrophic failures in flat slabs because of its sudden nature resulting from exceeding the shear capacity of slabs. Effect of using recycled aggregate, as an environmental-friendly alternative to traditional RC structures, on punching behavior of these slabs was not sufficiently investigated in the literature. Hence, this paper aims to experimentally study the effect of using recycled coarse aggregate (RCA) on the punching shear capacity (PSC) of RC flat slabs. The RCA is produced by crushing of waste of concrete standard cubes obtained from compression tests.

Design/methodology/approach
A total of 12 slab-column connection specimens with different slab thicknesses (140, 160 and 200 mm) and different RCA percentages (0%, 30% and 70%) were prepared and tested under a central point load, to test its effect on the behavior of flat slabs. The punching failure loads of the tested specimens were compared with those obtained according to the provisions of different international building codes.

Findings
Compared with natural aggregate concrete, mixes with 30% and 70% RCA experienced reductions in the compressive that did not exceed 4% and 21%, while reductions of 4% and 13% were observed for the tensile strength, respectively. The increase in the amount of RCA reduced the PSC by 0%–7%, 0%–4% and 4%–10% for slabs with a thickness of 140, 160 and 200 mm, respectively. For slabs with punching shear reinforcement (PSR), ACI 318 provided the closest estimation for the PSC by 9%, whereas EURO 2 overestimated the PSC by 25% and ECP 203 underestimated the PSC by 41%.

Research limitations/implications
The provided conclusions are obtained from the conducted experimental work where a constant W/C ratio, aggregate type and a maximum aggregate size of 19 mm for the RCA were adopted.

Originality/value
Enhancement in the behavior of flat slabs with various thicknesses and amounts of RCA because of introducing PSR is experimentally evaluated. The failure loads of the tested slabs with recycled and normal coarse aggregates were compared against different code provisions.
Secularization and its ethical consequences: orthodox Israeli Jews sanctifying ‘mundane’ Buddhist meditation
Authors: Mautner Ori 
Published: September 2022

Abstract‘Insight’ orvipassanāmeditation refers to meditative practices employed within Buddhist traditions. But following the secularization ofvipassanāin recent decades – that is, its differentiation from Buddhism – orthodox Jewish Israeli meditators frame it as a religiously neutral, therapeutic technique centred on the mundane human body. They thus consider it as involving no forbidden ‘Eastern’ religious contents. Nevertheless, these ‘Jewish Vipassanā’ meditators also utilize insight meditation for improving their Jewish practice, characters, and ability to experience closeness to God; and some situate it within a national‐religious historical narrative culminating in redemption. The secularization ofvipassanāenables orthodox Jewish practitioners to engage with it in ways that are significant for them as observant Jews, and without continually being concerned over ‘idolatry’. Secularization therefore has important implications for people's ethical projects, or attempts to foster what they consider good. Examining these implications can both stimulate secular studies and contribute to anthropological research on ethics.