bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digitale Lernangebote selbst gestalten
Authors: Henninger Sascha , Kaiser Tanja 
Published: December 2022

ZusammenfassungAusgehend vom Bedarf, Lehrpersonen zu befähigen, eigene digitale Lernangebote zu konzipieren, lerntheoretisch fundiert zu gestalten und zielgruppenorientiert einzusetzen, entwickelte die Fachdidaktik Geographie der TU Kaiserslautern (TUK) in Kooperation mit dem eTeaching Service Center (eTSC) des Distance and Independent Studies Center (DISC) den von Tutorinnen sowie Fachexperten und -expertinnen moderierten Online-Kurs „Digitale Lernangebote selbst gestalten“. Er adressierte in zwei Durchläufen bislang mehr als 600 Personen in Ausbildung und Beruf im Lehr-Lern-Kontext Schule sowie Erwachsenenbildung. Die Kommunikation in moderierten Foren ermöglichte es den Teilnehmenden und Lehrenden, unter- und miteinander in einen konstruktiven Diskurs zu treten. Was entstand, war eine komplexe Lerngelegenheit für alle Beteiligten, um digitale Lernangebote zur Gestaltung digitaler Lernumgebungen intensiver einsetzen zu können. Durch Peer-Lernen konnten die Teilnehmenden die eigenen fachlichen Inhalte und Vermittlungsmethoden durch das Feedback von Fachfremden reflektieren sowie Bestärkung in neuen kreativen Umsetzungsideen mit der im Kurs verwendeten Applikation erhalten. Der Beitrag skizziert konzeptionelle Überlegungen und den Aufbau des achtwöchigen Kurses sowie die Erfahrung mit dieser Öffnung der Hochschullehre für eine heterogene Teilnehmerschaft. Einige Kursinhalte wurden parallel zum Online-Kurs auch im Sinne des Blended Learning in fachdidaktischen Lehrveranstaltungen der Biologie und Geographie eingesetzt. Einzelne ausgewählte Lernangebote, die Studierende erstellt haben, werden ergänzend vorgestellt.
Anti-CD30 antibody–drug conjugate therapy in lymphoma: current knowledge, remaining controversies, and future perspectives
Authors: Prince H. Miles , Hutchings Martin , Domingo-Domenech Eva , Eichenauer Dennis A. , Advani Ranjana 
Published: December 2022

AbstractCD30 is overexpressed in several lymphoma types, including classic Hodgkin lymphoma (cHL), some peripheral T-cell lymphomas (PTCL), and some cutaneous T-cell lymphomas. The antibody–drug conjugate brentuximab vedotin targets CD30-positive cells and has been evaluated for the treatment of various lymphoma entities. This narrative review summarizes 10 years of experience with brentuximab vedotin for the treatment of CD30-positive lymphomas, discusses novel therapies targeting CD30 in development, and highlights remaining controversies relating to CD30-targeted therapy across lymphoma types. The collective body of evidence for brentuximab vedotin demonstrates that exploitation of CD30 can provide sustained benefits across a range of different CD30-positive lymphomas, in both clinical trials and real-world settings. Preliminary experience with brentuximab vedotin in combination with immune checkpoint inhibitors for relapsed/refractory cHL is encouraging, but further exploration is required. The optimal use of brentuximab vedotin for first-line therapy of PTCL remains to be determined. Further research is required on brentuximab vedotin treatment in high-risk patient populations, and in rare lymphoma subtypes, for which no standard of care exists. Novel therapies targeting CD30 include chimeric antigen receptor therapies and bispecific antibody T-cell engagers, which may be expected to further improve outcomes for patients with CD30-positive lymphomas in the coming years.
A randomised controlled trial evaluating internal limiting membrane peeling forceps in macular hole surgery
Authors: Ferrara Mariantonia , Rivera-Real Antonio , Hillier Roxane J. , Habib Maged , Kadhim Mustafa R. , Sandinha Maria T. , Curran Katie , Muldrew Alyson , Steel David H. W. 
Published: December 2022

Abstract
Purpose
To assess study design and a range of anatomical and functional changes after internal limiting membrane (ILM) peeling using forceps developed for atraumatic ILM pick-up compared to standard forceps.

Methods
We conducted a masked proof-of concept randomised controlled trial (RCT) on 65 patients who underwent ILM peeling for idiopathic full-thickness macular hole (FTMH) using etched-tip forceps (etched-tip group, 33 eyes) compared to standard ILM forceps (smooth-tip group, 32 eyes). Patients were assessed preoperatively, 3 weeks, 3 and 6 months postoperatively.

Results
The primary closure rate was 95.4%. There was no statistically significant difference between the groups in terms of final visual acuity (66.9 vs 70.9 ETDRS letters, p = 0.13), difference of visual field mean deviation (1.32 vs 1.14 decibels), and number of eyes with pick-up-related retinal haemorrhages (16% vs 16%, p = 0.96), swelling of arcuate nerve fibre layer lesions (63% vs 55%, p = 0.54), number of dissociated optic nerve fibre layer lesions (31.4 vs 41.0, p = 0.16), nor inner retina defects (37% vs 22%, p = 0.17). Similar changes in inner retinal volumes were detected in all 9 sectors of an ETDRS grid except for a trend (p = 0.06) towards a lower reduction in the inferior inner sector in the etched-tip group.

Conclusions
The study was successfully completed with masking maintained and a low risk of bias. Multiple endpoints relating to ILM peeling were assessed, and estimates were provided that can be used for future studies. Although the study was not powered to assess any specific endpoint, the anatomical and functional outcomes assessed did not significantly differ.
Conic formulation of QPCCs applied to truly sparse QPs
Authors: Bomze Immanuel M. , Peng Bo 
Published: December 2022

AbstractWe study (nonconvex) quadratic optimization problems with complementarity constraints, establishing an exact completely positive reformulation under—apparently new—mild conditions involving only the constraints, not the objective. Moreover, we also give the conditions for strong conic duality between the obtained completely positive problem and its dual. Our approach is based on purely continuous models which avoid any branching or use of large constants in implementation. An application to pursuing interpretable sparse solutions of quadratic optimization problems is shown to satisfy our settings, and therefore we link quadratic problems with an exact sparsity term $$\Vert {{\mathsf {x}}}\Vert _0$$

‖
x
‖

0

to copositive optimization. The covered problem class includes sparse least-squares regression under linear constraints, for instance. Numerical comparisons between our method and other approximations are reported from the perspective of the objective function value.
“Are They Going to Play Nicely?” Parents’ Evaluations of Young Children’s Play Dates
Authors: Lacey Alison J. , Banerjee Robin A. , Lester Kathryn J. 
Published: December 2022

AbstractOver the last 20 years, opportunities for young children to engage in self-directed free play with peers outdoors or during the school day has dramatically declined. Consequently, it is likely that play dates, defined as pre-arranged social contact at home, have become increasingly significant play environments for children. Preliminary research suggests that play dates are positively associated with young children’s social and emotional development, but that access can be strongly influenced by parental social networking priorities. However, little is currently known about the nature and frequency of play dates, the types of play children engage in, or the impact of parental management and supervision on children’s play in this context. Exploratory qualitative research is essential to understand the extent to which parental gatekeeping may limit opportunities for children and families perceived to have low social capital, and to begin to define the nature and content of young children’s play dates more broadly. Parents of children aged 5-6 years old took part in a semi-structured interview to describe common practices and attitudes (N = 11). Inductive thematic analysis indicated that play dates are complex play environments that parents associate with a range of social, emotional, and cognitive benefits for children. However, close parental monitoring and supervision may limit the extent to which play dates provide opportunities for self-directed free play. Findings also show that access to play dates is strongly influenced by parents’ motivations to enhance children’s social status which restricts access to some children. Implications for future research are discussed.
Detecting variable force in imperatives: A modalized minimal approach
Authors: Oikonomou Despina 
Published: December 2022

AbstractThis paper draws attention to various environments in Greek which show that imperatives convey possibility and not necessity as widely assumed in the literature. The interaction of imperatives with other operators reveals the presence of an existential operator. At the same time, however, it is shown that imperatives cannot be analysed as invariably conveying possibility. Instead, I suggest an analysis in which imperative verbal mood is semantically contentful, triggering a presupposition that results in a domain restriction for the set of evaluation worlds. Combining insights from both the modal (Schwager 2006; Kaufmann 2012) and the minimal approach (Portner 2004, 2007), I show that we can have a modalized minimal analysis if we take imperative verbal mood to be contentful at a presuppositional level. This twist allows us to capture the variable quantificational force of imperatives depending on the environment they appear in.
Using the past to understand future property acquisitions: an examination of historic voluntary and mandatory household relocations
Authors: Zavar Elyse , Binder Sherri Brokopp , Greer Alex , Breaux Amber 
Published: December 2022

AbstractAs climate change continues to exacerbate hazard losses across the USA, many communities are seeking to permanently reduce their hazard exposure by relocating households out of high-risk areas. In the USA, governments have traditionally relocated households using two mechanisms: buyout programs and eminent domain. Although both programs acquire private properties for public ownership and use, buyout programs are defined as voluntary by government entities, whereas eminent domain is compulsory. For decades, Harris County, Texas, has used both voluntary buyouts and eminent domain to relocate households out of flood-prone areas for different uses; buyouts produce open space, whereas eminent domain is used for flood risk reduction projects Although the literature on buyouts continues to grow, especially related to managed retreat, little research considers mandated relocation in response to hazard in the USA despite the increasing potential and calls for mandated relocations due to sea level rise and other climate-induced hazards. To address this gap in the literature, we analyze county records spanning approximately 100 years to examine the geographic patterns related to Harris County’s use of eminent domain and buyouts programs to mitigate flood hazards. Integrating these records into a Geographic Information System, this novel study is the first to compare these two programs and consider the implications for future managed retreat.
Boost Up the Mechanical and Electrical Property of CNT Fibers by Governing Lyotropic Liquid Crystalline Mesophases with Aramid Polymers for Robust Lightweight Wiring Applications
Authors: Ryu Ki-Hyun , Kim Jeong-Gil , Lee Dongju , Kim Seo Gyun , Ku Bon-Cheol , Hwang Jun Yeon , Jeong Kwang-Un , Kim Nam Dong , Kim Dae-Yoon 
Published: December 2022

AbstractMonofilament type of polyaromatic amide (PA) and carbon nanotube (CNT) composite fibers is presented. A concept of a lyotropic liquid crystal (LLC) constructed via a spontaneous self-assembly is introduced to mitigate the extremely low compatibility between PA and CNT. These approaches provide an effective co-processing route of PA and CNT simultaneously to fabricate the uniform, continuous, and reliable composite fibers through a wet-spinning. Interestingly, the addition of a small amount PA into the dope solution of CNT governs the LLC mesophase not only in a spinneret stage but also in a coagulant region. Thus, the developed PA/CNT composite fibers have the high uniaxial orientational order and the close interfacial packing compared to the pure CNT fibers. The PA/CNT composite fibers achieve the outstanding tensile strength, electrical conductivity, and electrochemical response, while maintaining a lightweight. They also exhibit the chemical, mechanical, and thermal robustness. All of these advantages can make flexible, sewable, and washable PA/CNT composite fibers ideal nanocomposite materials for use in next-generation information and energy transporting system by replacing conventional metal electrical conductors.
Graphical Abstract
The lyotropic liquid crystal self-assembly governed by doping the aramid polymers shows the ability to construct mechanically strong and continuous carbon nanotube-based composite fibers that can be used in the lightweight and robust electrical wiring for extreme environmental applications.
Improving the effectiveness of teacher assessment in higher education: a case study of professors’ perceptions in Morocco
Authors: St-Amand Jérôme , Rasmy Aziz , Nabil Abdessamed , Courdi Clémentine 
Published: December 2022

AbstractTeacher assessment in higher education is a widely used strategy in Western countries, but it is not common practice in Moroccan academia. In consequence, the establishment of a new assessment policy in higher education creates a new dynamic in teaching practices, teacher assessment, and professional career development. This type of major change, however, is likely to generate anxiety among staff regarding the learning of new practices, and uncertainty regarding their involvement in the process of teacher assessment. The objective of the present study was thus to explore the perceptions of professors concerning the implementation of teacher assessment in Moroccan universities through a survey and interviews carried out among the professors. The majority of professors expressed a positive attitude toward the usefulness of teaching evaluations. According to them, teacher assessment helps them identify strengths and weaknesses in their teaching. In contrast, there is a recurring issue among the respondents, namely the crisis of trust toward the parties involved in the evaluation process and apprehension regarding consequences of these evaluations’ results on faculty status and rank progression. The majority were very suspicious of using student assessment for administrative purposes.
Political Obligation and the Need for Justice
Authors: Walton Kevin 
Published: December 2022

AbstractThis paper examines the claim that justice is necessary for a moral obligation to obey the law. By reflecting on the meaning of obedience, it identifies one version of the claim that must be right and another that must be wrong. It then focuses on the argument for a moral obligation to obey the law that most obviously includes the claim: John Rawls’s argument from the natural duty of justice. More specifically, it focuses on the degree of justice that is needed for this duty to ground a moral obligation to obey the law.
Oral microbiota in cancer: could the bad guy turn good with application of polyphenols?
Authors: Antoniraj Mariya Gover , Devi Kasi Pandima , Berindan-Neagoe Ioana , Nabavi Seyed Fazel , Khayat Kashani Hamid Reza , Aghaabdollahian Safieh , Afkhami Farzaneh , Jeandet Philippe , Lorigooini Zahra , Khayatkashani Maryam , Nabavi Seyed Mohammad 
Published: December 2022

AbstractThe human oral cavity is comprised of dynamic and polynomial microbes which uniquely reside in the microenvironments of oral cavities. The cumulative functions of the symbiotic microbial communities maintain normal homeostasis; however, a shifted microbiota yields a dysbiosis state, which produces local and systemic diseases including dental caries, periodontitis, cancer, obesity and diabetes. Recent research reports claim that an association occurs between oral dysbiosis and the progression of different types of cancers including oral, gastric and pancreatic ones. Different mechanisms are proposed for the development of cancer, such as induction of inflammatory reactions, production of carcinogenic materials and alteration of the immune system. Medications are available to treat these associated diseases; however, the current strategies may further worsen the disease by unwanted side effects. Natural-derived polyphenol molecules significantly inhibit a wide range of systemic diseases with fewer side effects. In this review, we have displayed the functions of the oral microbes and we have extended the report regarding the role of polyphenols in oral microbiota to maintain healthy conditions and prevention of diseases with emphasis on the treatment of oral microbiota-associated cancer.
ENRIQUES INVOLUTIONS AND BRAUER CLASSES
Authors: SKOROBOGATOV A. N. , VALLONI D. 
Published: December 2022

AbstractWe prove that every element of order 2 in the Brauer group of a complex Kummer surface X descends to an Enriques quotient of X. In generic cases, this gives a bijection between the set
${\mathcal Enr}(X)$
of Enriques quotients of X up to isomorphism and the set of Brauer classes of X of order 2. For some K3 surfaces of Picard rank
$20,$
we prove that the fibers of
${\mathcal Enr}(X)\to \mathrm {{Br}}(X)[2]$
above the nonzero points have the same cardinality.
The crustose species of Normandina (Verrucariaceae)
Authors: Orange Alan 
Published: December 2022

AbstractNormandina acroglypta, as recently circumbscribed, is shown to comprise two species: N. acroglypta s. str. with subsquamulose marginal areoles, two unidentified terpenoids by thin-layer chromatography, and growing over rock; and N. chlorococca, with convex marginal areoles, zeorin or no substances detected by thin-layer chromatography, and growing over bark. Normandina dictyospora is newly described from the Falkland Islands and is characterized by relatively large, submuriform ascospores, and no substances detected.
A rare case of mycotic pseudoaneurysm in a patient post Rastelli procedure with infective endocarditis
Authors: Chua Cherrie , Then Kristie , Mohd Khalid Khairul Faizah 
Published: December 2022

AbstractMycotic pseudoaneurysm secondary to infective endocarditis is an uncommon complication in CHD with conduit placement. We report a case of late presentation of bacterial infective endocarditis with pseudoaneurysm in an 8-year-old girl with underlying pulmonary atresia with ventricular septal defect, post Rastelli procedure done at the age of 3 years old.
Transregional by design: The early communist press in the middle east and global revolutionary networks
Authors: Sayim Burak 
Published: December 2022

AbstractThis article traces the circulation of newspapers and journals as physical objects to reconstruct Middle Eastern communists’ global connections. I argue that post-First World War Middle Eastern and North African revolutionary militancy was closely linked to global networks. The extensive transregional and transimperial circulation of the communist press discussed here traces these close connections. The Communist International represented a novelty as a self-proclaimed centralist worldwide party. Distinctively, it brought together the means and the will to centralize (much of) global radicalism. This argument also serves to locate the early and mid-1920s as a transitional period in the history of left-wing movements: the means provided by a World Party intersected with the network-like structure of the pre-Comintern revolutionary milieux. The article aims to contribute to global history by discussing a regional – Middle Eastern – political current, not as the aggregate sum of its national components, but as a product of a global process.
Impacts of Sea‐Level Rise on Morphodynamics and Riverine Flooding in an Idealized Estuary
Authors: Ni Wuming , Morgan Jacob A. , Horner‐Devine Alexander R. , Kumar Nirnimesh , Ahrendt Shelby 
Published: December 2022

AbstractThis research simulates the morphodynamic evolution of an idealize estuary under four different SLR scenarios of increasing severity to investigate how SLR will influence riverine flooding in estuaries. We find that estuarine response to SLR is influenced by both morphological changes to channel capacity and the associated changes to channel hydrodynamics. Low and moderate SLR scenarios result in an increase in flood extent throughout the estuary relative to the no SLR base case. Surprisingly, more severe SLR scenarios result in decreased flood extent in upstream reaches. This shift is due to penetration of tidal energy and erosion further upstream with greater SLR, which increases channel capacity locally. A periodic pattern of local sediment transport is additionally observed due to SLR, which we attribute to the time response lag between hydrological and morphological response. The finding that increased SLR does not result in increased flood extent everywhere emphasizes that flood mitigation measures need to carefully account for non‐linear responses in the estuarine morphodynamic systems, such as the feedbacks resulting from increased tidal erosion.
Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania
Authors: Gardea-Resendez Manuel , Coombes Brandon J. , Veldic Marin , Tye Susannah J. , Romo-Nava Francisco , Ozerdem Aysegul , Prieto Miguel L. , Cuellar-Barboza Alfredo , Nunez Nicolas A. , Singh Balwinder , Pendegraft Richard S. , Miola Alessandro , McElroy Susan L. , Biernacka Joanna M. , Morava Eva , Kozicz Tamas , Frye Mark A. 
Published: December 2022

AbstractPreclinical evidence suggests that antidepressants (ADs) may differentially influence mitochondrial energetics. This study was conducted to investigate the relationship between mitochondrial function and illness vulnerability in bipolar disorder (BD), specifically risk of treatment-emergent mania (TEM). Participants with BD already clinically phenotyped as TEM+ (n = 176) or TEM− (n = 516) were further classified whether the TEM associated AD, based on preclinical studies, increased (Mito+, n = 600) or decreased (Mito−, n = 289) mitochondrial electron transport chain (ETC) activity. Comparison of TEM+ rates between Mito+ and Mito− ADs was performed using generalized estimating equations to account for participants exposed to multiple ADs while adjusting for sex, age at time of enrollment into the biobank and BD type (BD-I/schizoaffective vs. BD-II). A total of 692 subjects (62.7% female, 91.4% White, mean age 43.0 ± 14.0 years) including 176 cases (25.3%) of TEM+ and 516 cases (74.7%) of TEM- with previous exposure to Mito+ and/or Mito- antidepressants were identified. Adjusting for age, sex and BD subtype, TEM+ was more frequent with antidepressants that increased (24.7%), versus decreased (13.5%) mitochondrial energetics (OR = 2.21; p = 0.000009). Our preliminary retrospective data suggests there may be merit in reconceptualizing AD classification, not solely based on monoaminergic conventional drug mechanism of action, but additionally based on mitochondrial energetics. Future prospective clinical studies on specific antidepressants and mitochondrial activity are encouraged. Recognizing pharmacogenomic investigation of drug response may extend or overlap to genomics of disease risk, future studies should investigate potential interactions between mitochondrial mechanisms of disease risk and drug response.