bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multilayer Perceptron-based Predictive Model for the Reconstruction of Missing Rainfall Data
Authors: Narimani Roya , Jun Changhyun , De Michele Carlo , Gan Thian Yew , Nezhad Somayeh Moghimi 
Published: March 2022

Abstract
The quality and completeness of rainfall data is a critical aspect in time series analysis and for prediction of future water-related disasters. An accurate estimation of missing data is essential for better rainfall prediction results. Multilayer perceptron (MLP) neural networks have been applied to solve stochastic problems in data science. This study suggests a novel approach for estimating missing rainfall data using MLP neural networks based on three configurations that are represented by the monsoon season (MS), non-monsoon season, and non-seasonal variation. For this purpose, a mathematical model was created to analyze and predict the time series of daily rainfall data in Seoul, South Korea. Missing rainfall data were reconstructed using the rainfall data of the other five stations after removing rainfall data from station number two in three time periods. The results of this study indicate that the new architecture of the MLP can accurately predict the missing rainfall data, particularly in the MS configuration when using only the rainfall data obtained during the MS. The performance of the proposed model was tested using the following evaluation criteria: root mean square error, mean absolute error, correlation coefficient, mean absolute deviation, mean absolute percentage error, and standard deviation. The confusion matrix showed values of 89, 83, and 92% for accuracy, recall, and precision, respectively. This indicates that the proposed model can effectively perform rainfall data reconstruction and predict missing rainfall data accurately when the length of the statistical period is limited to the MS with a high volume of rainfall.
Chronic Stressors, Coping Strategies, and Depressive Symptoms: A Comparison across Older Age Groups
Authors: Sowan Wafaa , Rutin Renana , Cohen Miri 
Published: March 2022

Abstract
Background: Late-life depression is a prevalent mental health problem among older adults. Variations may exist in the intensity of chronic stressors experienced by people in different older age groups and their effects on depressive symptoms.Aim: To examine differences among older adults by age group in the experienced intensity of chronic stressors in relation to depressive symptoms and assess the mediating role of disengaged and engaged coping strategies.Methods: Participants were 114 older adults. The sample was divided into three age groups: 65–72, 73–81, and 82–91. The participants completed questionnaires on coping strategies, depressive symptoms, and chronic stressors. Moderation and mediation analyses were conducted.Results: The lowest levels of depressive symptoms were in the young-old age group and the highest levels were in the oldest-old age group. The young-old age group used more engaged and less disengaged coping strategies than the two other groups. The association between intensity of chronic stressors and depressive symptoms was stronger in the two older age groups compared to the youngest (moderating effect of age groups). The association of stressor intensity with depressive symptoms was mediated by disengaged coping, whereas engaged coping was not associated with depressive symptoms.Conclusion: Differences exist in the relationships among chronic stressors, coping strategies, and depressive symptoms by age groups in the older adult population. Professionals should be aware of these differences between age groups in depressive symptoms and the impact of stressors and coping strategies on depressive symptoms in different older adult age groups.
Minimally Invasive Plate Osteosynthesis (MIPO) for Distal Humeral Fractures – Small Incisions, Good Result
Authors: Hofmann Valeska , Deininger Christian , Diepold Julian , Moursy Mohamed , Birke Marco , Wichlas Florian 
Published: March 2022

Abstract
Background: The indication for minimally invasive plate osteosynthesis (MIPO) recently includes articular fractures. The goal of this study was to evaluate the feasibility of the MIPO technique for extra- and intra-articular distal humeral fractures.Methods: The feasibility of the MIPO technique was tested on 8 cadaveric elbows.The four surgical approaches tested were: a 20 mm ulnar incision, a 20 mm dorso-radial incision, and two for the olecranon osteotomy (A and B). The surgical incision A was 40 mm right on the osteotomy level of the olecranon, and B was an extension of the radial incision towards the osteotomy of the olecranon (80 mm).The four approaches were tested on 4 extra-articular (AO 13 A3) fractures and 4 intra-articular (AO 13 C3) fractures.Results: Reduction and plate fixation of all distal humeral fractures (8 cadaveric), with and without osteotomy, was feasible. But while approach A showed adequate intra-articular fracture control and reduction, approach B was too extensive to fulfill MIPO criteria. Nevertheless, both olecranon approaches were equal.Conclusion: The MIPO technique for reduction and plate fixation in distal humeral fractures is feasible.Level of Evidence: As a feasibility study, this is not clearly classified into a Level of Evidence. It corresponds most closely to level IV.
Early CT to detect posterior pelvic ring involvement, in fragility fractures of the pelvis, has no significant impact on outcome: a retrospective cohort study
Authors: Putzeys Guy , Dekeyser Thomas , Garré Patrick , Pottel Hans , Chesser Tim 
Published: March 2022

Abstract
Background
Early CT of acute fragility fractures of the pelvis (FFP) in the elderly allows evaluation of the posterior pelvic structures. This improves classification of these injuries, compared to plain radiographs but the contribution of this knowledge to clinical decision making remains unclear.
Objectives
Does early CT influences treatment and can it predict outcome and treatment failure?
Methods
A retrospective cohort study of 320 patients aged over 65 years diagnosed with an acute fragility fracture of the pelvis, at the emergency department of a single, level-one trauma centre. Data were retrieved from the German DGU Pelvic Injury Registry between 2009 and 2016. Fractures were classified according to the Tile classification. Statistical analysis compared the subgroups including radiograph only (X-RAY), CT with isolated pubic rami fracture (CTia) and CT with combined posterior pelvic fracture (CTcp).
Results
There were 285 female (89%) and 35 male (11%) subjects with a mean age of 83 years (range 65–102). 279 patients (87%) were living at home. 157 patients (49%) of the cohort had a CT scan showing 32 type A (20%); 114 type B (73%) and 11 type C (7%) fractures. 77% of patients living at home returned home and 17% moved to a nursing home, after discharge from the hospital. Mortality rate during hospitalisation was 5.0% and 14% at one-year post-trauma. Secondary fracture displacement occurred in 30%. Primary surgery was performed in two cases (1%); secondary surgery in 6 cases (2%). There was no significant association between subgroup (X-RAY, CTia, CTcp) and change in residential status (p = 0.98), complications during hospitalisation (p = 0.62) and mortality rate during admission (p = 0.94) and at 1 year (p = 0.89). A significant increased median length of stay was observed comparing subgroups CTcp (22 days) with subgroups CTia (15.5 days) and X-RAY (17 days) only. Secondary displacement was significantly higher in subgroup CTcp (p = 0.0403) but secondary displacement had no impact on complications nor mortality rate.
Conclusions
Our data suggest that early CT in patients with acute fragility fracture of the pelvis, in order to detect posterior lesions, does not add clinical useful information to guide treatment or affect outcome.
Relationship Between Bone Mineral Density and Related Factors in Puberty: a 4-year Longitudinal Survey
Authors: Akaike Arata , Suzuki Daisuke , Okuyama Shinya , Kudo Yutaro , Shimizu Hiroyasu , Takanashi Saya , Makino Kohei , Yokoyama Junichi , nakaji Shigeyuki 
Published: March 2022

Abstract
Bone fragility is a major factor in frail locomotive syndrome. For this fundamental measure, it is important to understand the changes in puberty, where bone metabolism is most active.The subjects were 277 boys and girls who participated in the Iwaki Health Promotion Project from 2011 to 2015 in both the fifth grade (10th/11th y.o) and the third grade of junior high school (14th/15th y.o). Bone mineral density and bone metabolism-related factors (physique and bone metabolism marker) during 4 years of puberty were examined. As for the physique at 10th/11th y.o, all factors were correlated with the bone density at 14th/15th y.o in boys and in girls, height, body muscle ratio, and grip strength value were correlated. In the 4-year rate of change, there was a positive correlation between height, body muscle rate, and bone mineral density in boys, but not in girls. For both boys and girls, a positive correlation was found between the physique (height, body muscle ratio, grip strength) in 10th/11th y.o, bone density at 14th/15th y.o, and bone metabolism markers.It is important to increase the peak bone mass: and prevent bone fragility by building a sufficient physique for boys (14th/15th y.o) and girls (10th/11th y.o).
Impact of Phacoemulsification versus combined Phacoemulsification-goniotomy on intraocular pressure in primary open-angle glaucoma patients
Authors: Awwad Mohamed Abdelzaher , Helal Hend Gouda , Hamouda Taisir , Mohamed Soha Moussa 
Published: March 2022

Abstract
Purpose:To assess the effect of phacoemulsification and combined phacoemulsification-goniotomy on intraocular pressure (IOP) in patients with primary open-angle glaucoma (POAG). Setting: Benha University HospitalDesign: A retrospective, observational, cohort study Patients and Methods:Sixty patients with cataract and POAG were allocated into two groups; group (P) had phacoemulsification, while group (PG) had combined phacoemulsification-goniotomy. Patients were subdivided into subgroups moderate (Pm and PGm) and severe (Ps and PGs) glaucoma based on the American Glaucoma Society classification of glaucoma severity. All patients had their presenting IOP, medicated IOP, number of IOP lowering medications, and postoperative IOP recorded. Postoperative IOP and IOP lowering drops number were followed up for 24 months after surgery. All intraoperative and postoperative complications were recorded and managed accordingly. Results:Group (P) showed an IOP reduction from 33±1.9 and 35±0.54 to 28±1.2 and 31±0.83 mmHg in subgroups Pm and Ps, respectively on the first postoperative week. All patients in group P needed to reinstate the IOP lowering drops with a non-significant change in the number of IOP reducing drops by the end of the study. In group (PG), a highly significant reduction in postoperative IOP was noted in the first postoperative week from 31±0.9 and 34±0.29 to 14±0.9 and 26±1.2 mmHg in subgroups PGm and PGs respectively P-value <0.0001). Patients with moderate glaucoma had stopped all IOP lowering drops, while those with severe glaucoma needed fewer medications by the end of the study.Conclusion:Combined phacoemulsification-goniotomy is superior to phacoemulsification alone in cases of POAG in terms of IOP control, especially for moderate POAG.
Associations between children’s physical literacy and well-being: is physical activity a mediator?
Authors: Melby Paulina S. , Nielsen Glen , Brønd Jan Christian , Tremblay Mark S. , Bentsen Peter , Elsborg Peter 
Published: March 2022

Abstract
Background
Physical literacy (PL) is a multi-dimensional concept that provides a holistic understanding of movement and physical activity. PL contains an affective, a physical, and a cognitive domain, which together lay the foundation for the individual’s capacity and the tendency for participating in physical activities currently and throughout life. PL is increasingly regarded as a ‘cause of the causes’ to health promotion. Cross-sectional studies have shown associations between children’s PL, physical activity behaviours, and well-being. This study aims to examine the associations between Danish children’s PL and their physical and psychosocial well-being and whether the associations are mediated by moderate- to vigorous intensity physical activity (MVPA).
Methods
Cross-sectional data from Danish schoolchildren aged 7–13 years were collected in Jan-Dec 2020 in the Danish Assessment of Physical Literacy (DAPL) project. PL was assessed with the DAPL which measures the affective, cognitive, and physical domains of PL. MVPA (min/day) was measured with accelerometers (Axivity), psychosocial well-being was measured with The Strengths and Difficulties Questionnaire, and physical well-being was measured with the KIDSCREEN questionnaire. Structural equation models were constructed with PL and MVPA as predictors of physical well-being and four aspects of psychosocial well-being.
Results
A positive moderate association between PL and physical well-being, partly mediated by MVPA was observed. PL was positively associated with the positive aspects of psychosocial well-being and negatively associated with the negative aspects (behaviour problems). None of the associations between PL and aspects of psychosocial well-being were mediated by MVPA.
Conclusions
The study contributes to evidence on the link between PL, physical activity, and health outcomes. The study found beneficial relations between PL and physical and psychosocial well-being.
Implications of Bacteriological Study in Perforated Peptic Ulcer Peritonitis
Authors: Cimpean Sorin , Barranquero Alberto Gonzalez , Cadiere Benjamin , Cadiere Guy-Bernard 
Published: March 2022

Abstract
Background
In the setting of perforated pepticulcer (PPU) peritonitis, empiric antimicrobial therapy is initiated perioperatively and adapted according to the culture sensitivity. This attitude may reduce the incidence of postoperative complications. The aim of the study is to describe the microbiota found in the peritonitis due to a PPU, and to evaluate the predictors for bacterial or fungal infection.
Material and methods
We performed a single-centre, retrospective observational study of all consecutive patients who presented with PPU peritonitis and underwent emergent surgery in Saint Pierre University Hospital, Brussels, Belgium, between January 2013 and December 2020. The medical history, parameters at admission, bacterial culture, antibiotic resistance and postoperative outcomes were analysed.
Results
A total of 43 patients were included in the study. The microbiological culture rate was positive in 31% (13/43) patients, with presence of bacteria in 20.9% (9/43) and fungal infection in 16.7% (7/43) patients. The bacterial culture revealed that the most frequently isolated bacteria were Klebsiella spp. and Enterobacter in 7% (3/43) of the patients, while the most prevalent fungus isolation was Candida spp. in 16.7% (7/43) patients. There was as overall resistant rate of 17.5%. The most prevalent resistances were against ampicillin (17.1% [7/43]), and amoxicillin/clavulanic acid (9.5% [4/43]). The Charlson Comorbidity Index was an independent predictor for bacterial infection. No factors could be identified as predictors of fungal infection.
Conclusion
Candida spp., Klebsiella spp. and Enterobacter were the most common organisms isolated in the setting of PPU peritonitis.
Classification and Reconstruction of Femoral Bone Defect in the Revision of Aseptic Loosening of Distal Femoral Endoprostheses: A 10-year Multicenter Retrospective Analysis
Authors: Hou Zi-Wei , Xu Ming , Zheng Kai , Yu Xiu-Chun 
Published: March 2022

Abstract
Objective
This study proposes a system for classifying the aseptic loosening of distal femoral prostheses and discusses reconstruction methods for revision surgery, based on different classification types.
Methods
We retrospectively analyzed the data of patients who received revision surgery for aseptic loosening in distal femoral tumor endoprosthesis from January 2008 to December 2018 at 3 bone tumor treatment centers in China. On the basis of the patient imaging data, we proposed a classification system for the aseptic loosening of distal femoral endoprostheses and discussed its revision surgery strategy for various bone defects.
Results
A total of 29 patients were included in this study, including 20 males and 9 females aged 15–64 y (average: 43.2 y). First-revision surgery was performed on 25 patients, whereas second-revision surgery was conducted on 4 patients. The 29 patients were classified into different types based on the degree of aseptic loosening: Type Ia, 5 patients (17.2%); Type Ib, 7 patients (24.1%); Type IIa, 9 patients (31.0%); Type IIb, 7 patients (24.1%); and Type IIIb, 1 patient (3.4%). Four Type Ia patients used the longer-stem rotating hinge prosthesis, and 1 Type Ia patient used the original prosthesis. Six Type Ib patients used a longer-stem rotating hinge, and 1 Type Ib patient used the original prosthesis plus bone grafting with an allograft bone plate for revision. Eight Type IIa patients underwent revision with a longer-stem rotating hinge prosthesis, and 1 Type IIa patient received revision surgery with the original prosthesis plus bone grafting with an allograft bone plate. Meanwhile, 5 Type IIb and 1 Type IIIb patients used a longer-stem rotating hinge prosthesis, and 2 Type IIb patients used the original prosthesis for revision.
Conclusions
Aseptic loosening of the distal femoral prosthesis can be divided into 4 types and 8 subtypes. Different types of bone defect can be repaired with the appropriate reconstruction.
Genetic characteristics of Coxsackievirus A6 from children with hand, foot and mouth disease in Beijing, China, 2017–2019
Authors: Zhang Meng , Chen Xiangpeng , Wang Wei , Li Qi , Xie Zhengde 
Published: March 2022

Abstract
Object:
To investigate the evolutionary and genetic characteristics of Coxsackievirus A6 (CV-A6) which acted as the predominant pathogen of hand, foot and mouth disease (HFMD) in children in Beijing, China, during 2017–2019.
Methods
Throat swab specimens were collected for general Enterovirus (EV), EV-A71 and CV-A16 detection by Real-time PCR. These general EV-positive samples were identified by semi-nested RT-PCR method and sequencing. The CV-A6 VP1 gene and genome sequences were amplified sequenced. The phylogenetic, variation and recombination analyses were performed.
Results
A total of 1721 HFMD patients were enrolled in this study, with the male to female ratio of 1.62:1. The majority of cases were less than five years, which accounted for 73.50%. The overall detection rate of EV was 88.32% (1520/1721). A total of 8 EV types were identified (CV-A6 (55.86%), CV-A16 (26.32%), EV-A71 (2.24%), CV-A10 (2.04%), CV-A4 (1.05%), CV-A5 (0.59%), CV-A2 (0.33%), and CV-A8 (0.07%), while 175 (11.51%) EV were untyped. The main pathogen of HFMD is CV-A6 from 2017 to 2018, while CV-A6 and CV-A16 are the main causative pathogens in 2019. The nucleotide and amino acid sequence identities of the 120 CV-A6 complete VP1 gene sequences in this study were 91.2–100.0% and 97.7–100.0%, respectively. Compared with the prototype strain (Gdula) of CV-A6, the nucleotide and amino acid sequence identities were 81.7–84% and 94.7–96.3%, respectively. The phylogenetic tree indicated that all 120 CV-A6 sequences belonged to sub-genotype D3, while 119 CV-A6 sequences belonged to evolutionary branch D3a, except one from 2017 belonged to D3b. Recombination analyses based on the complete genome sequences showed that potential multiple recombination may have occurred in 2B and 3D protein coding regions with EV-A114.
Conclusions
The main pathogens of HFMD were CV-A6 and CV-A16 in Beijing, China between 2017 and 2019; while these CV-A6, as recombination strains, belonged to the D3a evolutionary branch.
Wave-Based Analysis of Jointed Elastic Bars: Nonlinear Periodic Response
Authors: Balaji Nidish Narayanaa , Brake Matthew R. W. , Leamy Michael Joseph 
Published: March 2022

Abstract
In this paper we develop two wave-based approaches for predicting the nonlinear periodic response of jointed elastic bars. First, we present a nonlinear wave-based vibration approach (WBVA) for studying jointed systems informed by re-usable, perturbation-derived scattering functions. This analytical approach can be used to predict the steady-state, forced response of jointed elastic bar structures incorporating any number and variety of nonlinear joints. As a second method, we present a nonlinear Plane-Wave Expansion (PWE) approach for analyzing periodic response in the same jointed bar structures. Both wave-based approaches have advantages and disadvantages when compared side-by-side. The WBVA results in a minimal set of equations and is re-usable following determination of the reflection and transmission functions, while the PWE formulation can be easily applied to new joint models and maintains solution accuracy to higher levels of nonlinearity. For example cases of two and three bars connected by linearly-damped joints with linear and cubic stiffness, the two wave-based approaches accurately predict the expected Duffing-like behavior in which multiple periodic responses occur in the near-resonant regime, in close agreement with reference finite element simulations. Lastly, we discuss extensions of the work to jointed structures composed of beam-like members, and propose follow-on studies addressing opportunities identified in the application of the methods presented.
Correlations between Diffusion-Weighted and Intravoxel Incoherent Motion Parameters with Ki-67 Index in Gastric Adenocarcinoma
Authors: Yuan Letian , Lin Xiangtao , Zhao Peng , Duan Shuai , Ma Hui , Diao Ruiyuan , Cai Shuo , Sun Shanshan 
Published: March 2022

Abstract
Background：Intravoxel incoherent motion imaging (IVIM) and DWI have been applied for gastric adenocarcinoma.Purpose: To investigate correlation between parameters of IVIM and DWI with Ki-67 in gastric adenocarcinoma.Materials and methods: A total of 64 gastric adenocarcinoma patients were enrolled into the research and received DWI and IVIM at 3.0T MRI before the surgery. Based on the setting of ROIs, the DWI and IVIM parameters (including ADC, ture diffusion coefficient (D), perfusion fraction (f) and pseudo-diffusion coefficient (D*)) of each patient's gastric adenocarcinoma were measured and calculated. According to expression of Ki-67, participated subjects were divided into two groups (low Ki-67 group and high Ki-67 group). The intraclass correlation coeffificient (ICC) was used to assess the consistency of each parameter measured by two radiologists. The independent-sample t-test was used to compare differences of each parameter between groups. Spearman correlation coefficient was calculated to reveal the correlation between Ki-67 with parameters. By using the area under the curve (AUC) of the receiver operating characteristic (ROC) curve, each parameter was compared. Results: The ADC, D and f values of high Ki-67 group were all lower than those of low Ki-67 group [(10.89±0.89) × 10−2 mm2/s vs. (14.65±0.46)× 10−2 mm2/s, (9.95±0.92) × 10−2 mm2/s vs. (12.48±0.83) × 10−2 mm2/s, (2.30±0.51) × 10−2 mm2/s vs. (3.75±0.85) × 10−2 mm2/s, all P < 0.05]. Except for D*, ADC, D and f were negatively correlated with the expression of Ki-67 (r = −0.725, −0.733, -0.666, all P < 0.05). The areas under the curve (AUC) of ADC, D and f were 0.901, 0.923 and 0.657 respectively (Table 5). The difference of AUC value between ADC and D was not statistically significant (AUCD = 0.923 vs. AUCADC= 0.901, Z=0.290, P=0.772). The difference of AUC value between ADC and f was statistically significant (AUCADC= 0.901 vs. AUCf= 0.657, Z=2.329, P=0.025). The difference of AUC value between D and f was statistically significant (AUCD= 0.923 vs. AUCf= 0.657, Z=2.124, P=0.034) (Table 6).Conclusions: DWI and IVIM can effectively reflect the proliferative characteristics of gastric adenocarcinoma. D and ADC have higher diagnostic efficiency than f.