bluuebunny/crossref_metadata_2025_split huggingface dataset:
A high efficiency fluidly reconfigurable antenna with detached feeding
Authors: Huang Jinfeng , Xing Lei , Xu Qian 
Published: April 2022

AbstractIn this study, a pure water antenna with a tunable radiation pattern is proposed, which combines the idea of the Yagi antenna and the reflector antenna to realize a steerable directional beam. By sufficiently utilizing the excellent features of water: fluidity, transparency, and reconfigurability, this proposed design achieves a 360° beam coverage. In addition, a detached feeding structure is introduced to effectively avoid liquid leakage and corrosion. This type of antenna has 25 different working states covering the working frequency from 2.36 to 2.6 GHz (S11 < −10 dB), a high radiation efficiency (70%), and a maximum realized gain of 5.8 dB. This design is expected to be a promising candidate for the internet of things applications.
Dynamic pulmonary MRI using motion‐state weighted motion‐compensation (MostMoCo) reconstruction with ultrashort TE: A structural and functional study
Authors: Ding Zekang , Cheng Zenghui , She Huajun , Liu Bei , Yin Yongfang , Du Yiping P. 
Published: April 2022

PurposeTo improve the quality of structural images and the quantification of ventilation in free‐breathing dynamic pulmonary MRI.MethodsA 3D radial ultrashort TE (UTE) sequence with superior–inferior navigators was used to acquire pulmonary data during free breathing. All acquired data were binned into different motion states according to the respiratory signal extracted from superior–inferior navigators. Motion‐resolved images were reconstructed using eXtra‐Dimensional (XD) UTE reconstruction. The initial motion fields were generated by registering images at each motion state to other motion states in motion‐resolved images. A motion‐state weighted motion‐compensation (MostMoCo) reconstruction algorithm was proposed to reconstruct the dynamic UTE images. This technique, termed as MostMoCo‐UTE, was compared with XD‐UTE and iterative motion‐compensation (iMoCo) on a porcine lung and 10 subjects.ResultsMostMoCo reconstruction provides higher peak SNR (37.0 vs. 35.4 and 34.2) and structural similarity (0.964 vs. 0.931 and 0.947) compared to XD‐UTE and iMoCo in the porcine lung experiment. Higher apparent SNR and contrast‐to‐noise ratio are achieved using MostMoCo in the human experiment. MostMoCo reconstruction better preserves the temporal variations of signal intensity of parenchyma compared to iMoCo, shows reduced random noise and improved sharpness of anatomical structures compared to XD‐UTE. In the porcine lung experiment, the quantification of ventilation using MostMoCo images is more accurate than that using XD‐UTE and iMoCo images.ConclusionThe proposed MostMoCo‐UTE provides improved quality of structural images and quantification of ventilation for free‐breathing pulmonary MRI. It has the potential for the detection of structural and functional disorders of the lung in clinical settings.
Styrene‐butadiene‐styrene‐based shape memory polymers: Evolution and the current state of art
Authors: Basak Sayan , Bandyopadhyay Abhijit 
Published: April 2022

AbstractStyrene butadiene styrene (SBS) block copolymers comprise of two phases structured domains involving polystyrene “hard” domains and butadiene “soft” domains. The styreneic domains provide a physical crosslink that enables SBS to behave like a highly flexible thermoplastic elastomer. Recently, with the rise of smart elastomers, SBS‐based matrices are being extensively used in transforming them into elastomers that can exhibit shape change when excited with a range of stimuli (shape memory elastomers). With the advantages of long‐range elasticity, reprocessability, and ability to be modified into various tailor‐made shape morphing elastomers, the use SBS‐based elastomers has exceptionally risen in the scope of deployable structures temperature sensors, snap fittings, and actuators. This review attempts to tether the recent development in SBS‐based shape memory polymers along with highlighting the fabrication routes and the shape memory mechanistic pathway. The review introduces the concept of shape memory polymers, classification, and their characterization, followed by shape memory elastomers and finally one way/two‐way SBS‐based shape memory elastomers. In an attempt to blend both the scientific and the engineering realm, the narrative provides a concise overview of SBS‐based shape morphing polymers' expanding boundaries.
What is the prevalence of fear of cancer recurrence in cancer survivors and patients? A systematic review and individual participant data meta‐analysis
Authors: Luigjes‐Huizer Yvonne L. , Tauber Nina M. , Humphris Gerry , Kasparian Nadine A. , Lam Wendy W. T. , Lebel Sophie , Simard Sébastien , Smith Allan Ben , Zachariae Robert , Afiyanti Yati , Bell Katy J. L. , Custers José A. E. , de Wit Niek J. , Fisher Peter L. , Galica Jacqueline , Garland Sheila N. , Helsper Charles W. , Jeppesen Mette M. , Liu Jianlin , Mititelu Roxana , Monninkhof Evelyn M. , Russell Lahiru , Savard Josée , Speckens Anne E. M. , van Helmondt Sanne J. , Vatandoust Sina , Zdenkowski Nicholas , van der Lee Marije L. 
Published: April 2022

AbstractObjectiveCare for fear of cancer recurrence (FCR) is considered the most common unmet need among cancer survivors. Yet the prevalence of FCR and predisposing factors remain inconclusive. To support targeted care, we provide a comprehensive overview of the prevalence and severity of FCR among cancer survivors and patients, as measured using the short form of the validated Fear of Cancer Recurrence Inventory (FCRI‐SF). We also report on associations between FCR and clinical and demographic characteristics.MethodsThis is a systematic review and individual participant data (IPD) meta‐analysis on the prevalence of FCR. In the review, we included all studies that used the FCRI‐SF with adult (≥18 years) cancer survivors and patients. Date of search: 7 February 2020. Risk of bias was assessed using the Joanna Briggs Institute critical appraisal tool.ResultsIPD were requested from 87 unique studies and provided for 46 studies comprising 11,226 participants from 13 countries. 9311 respondents were included for the main analyses. On the FCRI‐SF (range 0–36), 58.8% of respondents scored ≥13, 45.1% scored ≥16 and 19.2% scored ≥22. FCR decreased with age and women reported more FCR than men. FCR was found across cancer types and continents and for all time periods since cancer diagnosis.ConclusionsFCR affects a considerable number of cancer survivors and patients. It is therefore important that healthcare providers discuss this issue with their patients and provide treatment when needed. Further research is needed to investigate how best to prevent and treat FCR and to identify other factors associated with FCR.The protocol was prospectively registered (PROSPERO CRD42020142185).
An Energetic Coordination Polymer with High Thermal Stability and Initiation Power
Authors: Huang Wei , Yin Zhaoyang , Dong Yaqun , Liu Yuji , Tang Yongxing 
Published: April 2022

AbstractLead‐free, eco‐friendly primary explosive which can replace lead azide (LA) has been a long‐lasting challenge. Hereby, a new candidate copper(I) 5‐(2,2‐diamino‐1‐nitrovinyl)tetrazolate (CTX) was synthesized through a mild metathesis reaction by bridging nitrogen‐rich heterocycles with Cu(I) centers. The structure was characterized with IR spectrum, NMR spectrum, X‐ray diffraction, and elemental analysis. The linear reinforced structure and condensed packing pattern of CTX lead to its high density (2.16 g cm−3) and low sensitivities (IS=10 J, FS>120 N). It also exhibits a remarkably high thermal stability (340 °C), which to our knowledge, is the highest one known for the energetic coordination polymers (ECPs). The initiation capability test reveals CTX has high priming ability comparable to LA. The combined properties and performances contribute to its future prospects as a promising green primary explosive.
Intrathoracic lipoma of the chest wall that appeared relatively rapidly and could be resected and diagnosed by minimally invasive thoracoscopic surgery: A case report
Authors: Hirai Yoshimitsu , Mikasa Yurina , Iguchi Hideto , Fusamoto Aya , Yata Yumi , Ohashi Takuya , Nishimura Yoshiharu 
Published: April 2022

AbstractThe occurrence of lipoma in the thoracic cavity is relatively rare, and it is clinically difficult to distinguish it from liposarcoma. We report a case of intrathoracic lipoma that was pathologically diagnosed and differentiated from liposarcoma after minimally invasive thoracoscopic tumour resection. A 35‐year‐old male patient without any symptoms was referred to our hospital due to an abnormal shadow on chest x‐ray. Computed tomography showed a low‐attenuated round‐shaped mass of 3.6 cm × 2.3 cm in diameter in the left chest wall. On magnetic resonance imaging, the mass was displayed as a high, high and low signal mass on T1‐weighted imaging (WI), T2WI and T2WI with fat suppression, respectively. We suspected a chest wall‐type lipoma, but because it appeared in a relatively short period of time and we thought it could be liposarcoma, we performed minimally invasive thoracoscopic surgery for diagnosis and treatment. The tumour was a stalked tumour with a capsule, contiguous to the wall pleura with only a single cord‐like structure. The majority of the tumour was found free in the pleural cavity. The tumour was diagnosed as a lipoma by histopathological examination.
One‐Step Template‐Free Laser Patterning of Metal Microhoneycomb Structures
Authors: Hwang June Sik , Arthanari Srinivasan , Park Jong‐Eun , Yang Minyang , Kim Sanha , Kim Seung‐Woo , Lee Huseung , Kim Young‐Jin 
Published: April 2022

AbstractMetal microhoneycomb structures have received considerable attention as a type of interaction‐efficient functional devices owing to their unique morphology and material properties. Microhoneycomb structures are mainly fabricated using the well‐known breath‐figure method. However, additional post‐treatments are required to produce a metal structure because it is a polymer‐based process, and this necessitates expensive, complex, and multi‐step fabrication processes. Therefore, a simple, low‐cost metal honeycomb fabrication process is necessary. In this paper, the laser patterning of an organometallic solution to produce silver microhoneycomb (Ag microhoneycomb) structures is proposed. Various phenomena such as rapid organic evaporation, silver nanoparticle solidification, and material reorganization from Marangoni flow are found to enable patterning‐induced microhoneycomb formation. Parametric studies demonstrate that the pore size can be easily controlled through simple laser parameter changes. In addition, cyclic voltammetry and electrochemical impedance spectroscopy studies confirm the potential electrochemical applications of the Ag microhoneycomb structures based on the variation of electrochemical redox behavior depending on the pore size. Owing to the excellent advantages of one‐step laser patterning without any templates, the proposed process will likely promote the practical use of the metal microhoneycomb structures.
Trogbrücke über die Broye – Eine Fußgänger‐ und Fahrradbrücke aus wetterfestem Stahl mit lasergeschnittenen Stegen
Authors: Guscetti Gabriele , Bouleau Etienne , Colomer Pierre , Bigelow Hetty 
Published: April 2022

AbstractDie Fußgänger‐ und Fahrradbrücke über die Broye (Schweiz) bindet das neue Wohnviertel Rives de la Broye an die in der Nähe gelegene Stadt Payerne an. Der Überbau der 36 m langen Trogbrücke besteht aus 26 t wetterfestem Stahl. Die Ausführung als Stahltrog stellt sicher, dass sich der Brückenüberbau oberhalb des Hochwasserpegels befindet. Die Stege und die Oberflansche des Trogs haben dabei nicht nur eine statische Funktion, sondern sind gleichzeitig die Geländer bzw. Handläufe der Brücke. Die Stege sind von einem Lochmuster durchzogen, welches am Computer generiert und mittels einer CNC‐Lasermaschine ausgeschnitten wurde. Die Lochverteilung wurde in Abhängigkeit von den Kraftverläufen in den Stegen gewählt. Das verbleibende Material folgt den Spannungstrajektorien in den Stegen. Die jeweilige Lochgröße richtet sich dabei nach der lokalen Beanspruchung der Stege. Das Muster lässt die Brücke nicht nur transparenter und optisch leichter erscheinen, sondern trägt auch zur Gewichtsreduktion und Materialersparnis bei. Der Überbau der Brücke wurde vollständig im Werk vorfabriziert und anschließend innerhalb weniger Stunden mithilfe eines Autokrans auf die Widerlager gesetzt. An den Widerlagern wird jeweils durch ein Druck‐ und ein Zugauflager eine Einspannwirkung erzeugt, welche sich positiv auf die Durchbiegung in Feldmitte und die dynamischen Eigenschaften des Überbaus auswirkt. Die Lager sind in Lagerebene verschieblich, um Temperaturunterschiede auszugleichen.
RNA splicing regulators play critical roles in neurogenesis
Authors: Fisher Emily , Feng Jian 
Published: April 2022

AbstractAlternative RNA splicing increases transcript diversity in different cell types and under varying conditions. It is executed with the help of RNA splicing regulators (RSRs), which are operationally defined as RNA‐binding proteins (RBPs) that regulate alternative splicing, but not directly catalyzing the chemical reactions of splicing. By systematically searching for RBPs and manually identifying those that regulate splicing, we curated 305 RSRs in the human genome. Surprisingly, most of the RSRs are involved in neurogenesis. Among these RSRs, we focus on nine families (PTBP, NOVA, RBFOX, ELAVL, CELF, DBHS, MSI, PCBP, and MBNL) that play essential roles in the neurogenic pathway. A better understanding of their functions will provide novel insights into the role of splicing in brain development, health, and disease. This comprehensive review serves as a stepping‐stone to explore the diverse and complex set of RSRs as fundamental regulators of neural development.This article is categorized under:
RNA‐Based Catalysis > RNA Catalysis in Splicing and Translation
RNA Interactions with Proteins and Other Molecules > Protein‐RNA Interactions: Functional Implications
RNA Processing > Splicing Regulation/Alternative Splicing
Simulation and Control of Deformable Autonomous Airships in Turbulent Wind
Authors: Price Eric , Liu Yu Tang , Black Michael J. , Ahmad Aamir 
Published: April 2022

AbstractFixed wing and multirotor UAVs are common in the field of robotics. Solutions for simulation and control of these vehicles are ubiquitous. This is not the case for airships, a simulation of which needs to address unique properties, i) dynamic deformation in response to aerodynamic and control forces, ii) high susceptibility to wind and turbulence at low airspeed, iii) high variability in airship designs regarding placement, direction and vectoring of thrusters and control surfaces. We present a flexible framework for modeling, simulation and control of airships. It is based on Robot operating system (ROS), simulation environment (Gazebo) and commercial off the shelf (COTS) electronics, all of which are open source. Based on simulated wind and deformation, we predict substantial effects on controllability which are verified in real-world flight experiments. All our code is shared as open source, for the benefit of the community and to facilitate lighter-than-air vehicle (LTAV) research. (Source code:https://github.com/robot-perception-group/airship_simulation.)
Supersymmetric vortex loops in 3D gauge theories
Authors: Hosomichi Kazuo , Suzuki Kohei 
Published: April 2022

Abstract
We give a precise definition of BPS vortex loops in 3D non-abelian gauge theories with $$ \mathcal{N} $$
N
= 2 SUSY by the path integral over fields with a prescribed singular behavior. We compute the expectation value of a BPS vortex loop on an ellipsoid. Using the result we revisit the known equivalence between Wilson and vortex loops in pure Chern-Simons theory. Naive computations of expectation values in $$ \mathcal{N} $$
N
= 2 theory leads to an unwanted shift of parameters in the rule of correspondence. We resolve the problem by relating the shift to the global anomaly of $$ \mathcal{N} $$
N
= 2 SUSY quantum mechanics. For theories with U(N) gauge group we also develop an alternative description of vortex loops in terms of 1D $$ \mathcal{N} $$
N
= 2 SUSY quantum mechanics on their worldline. For vortex loops in $$ \mathcal{N} $$
N
= 4 theories, our construction reproduces some of the quiver GLSMs of Assel and Gomis.
Structural mechanism of TRPM7 channel regulation by intracellular magnesium
Authors: Schmidt Eva , Narangoda Chamali , Nörenberg Wolfgang , Egawa Miyuki , Rössig Anna , Leonhardt Marion , Schaefer Michael , Zierler Susanna , Kurnikova Maria G. , Gudermann Thomas , Chubanov Vladimir 
Published: April 2022

AbstractZn2+, Mg2+ and Ca2+ are essential divalent cations implicated in many metabolic processes and signalling pathways. An emerging new paradigm is that the organismal balance of these cations predominantly depends on a common gatekeeper, the channel-kinase TRPM7. Despite extensive electrophysiological studies and recent cryo-EM analysis, an open question is how the channel activity of TRPM7 is activated. Here, we performed site-directed mutagenesis of mouse TRPM7 in conjunction with patch-clamp assessment of whole-cell and single-channel activity and molecular dynamics (MD) simulations to show that the side chains of conserved N1097 form an inter-subunit Mg2+ regulatory site located in the lower channel gate of TRPM7. Our results suggest that intracellular Mg2+ binds to this site and stabilizes the TRPM7 channel in the closed state, whereas the removal of Mg2+ favours the opening of TRPM7. Hence, our study identifies the structural underpinnings through which the TRPM7 channel is controlled by cytosolic Mg2+, representing a new structure–function relationship not yet explored among TRPM channels.
Prolonged exposure to simulated microgravity promotes stemness impairing morphological, metabolic and migratory profile of pancreatic cancer cells: a comprehensive proteomic, lipidomic and transcriptomic analysis
Authors: Masini Maria Angela , Bonetto Valentina , Manfredi Marcello , Pastò Anna , Barberis Elettra , Timo Sara , Vanella Virginia Vita , Robotti Elisa , Masetto Francesca , Andreoli Francesca , Fiore Alessandra , Tavella Sara , Sica Antonio , Donadelli Massimo , Marengo Emilio 
Published: April 2022

Abstract
Background
The impact of the absence of gravity on cancer cells is of great interest, especially today that space is more accessible than ever. Despite advances, few and contradictory data are available mainly due to different setup, experimental design and time point analyzed.

Methods
Exploiting a Random Positioning Machine, we dissected the effects of long-term exposure to simulated microgravity (SMG) on pancreatic cancer cells performing proteomic, lipidomic and transcriptomic analysis at 1, 7 and 9 days.

Results
Our results indicated that SMG affects cellular morphology through a time-dependent activation of Actin-based motility via Rho and Cdc42 pathways leading to actin rearrangement, formation of 3D spheroids and enhancement of epithelial-to-mesenchymal transition. Bioinformatic analysis reveals that SMG may activates ERK5/NF-κB/IL-8 axis that triggers the expansion of cancer stem cells with an increased migratory capability. These cells, to remediate energy stress and apoptosis activation, undergo a metabolic reprogramming orchestrated by HIF-1α and PI3K/Akt pathways that upregulate glycolysis and impair β-oxidation, suggesting a de novo synthesis of triglycerides for the membrane lipid bilayer formation.

Conclusions
SMG revolutionizes tumor cell behavior and metabolism leading to the acquisition of an aggressive and metastatic stem cell-like phenotype. These results dissect the time-dependent cellular alterations induced by SMG and pave the base for altered gravity conditions as new anti-cancer technology.
Risk of coronary stenosis after adjuvant radiotherapy for breast cancer
Authors: Wennstig A.-K. , Garmo H. , Wadsten L. , Lagerqvist B. , Fredriksson I. , Holmberg L. , Blomqvist C. , Nilsson G. , Sund M. 
Published: April 2022

Abstract
Purpose
Adjuvant radiotherapy (RT) for breast cancer is associated with an increased risk of ischemic heart disease. We examined the risk of coronary artery stenosis in a large cohort of women with breast cancer receiving adjuvant RT.

Methods
A cohort of women diagnosed with breast cancer between 1992 and 2012 in three Swedish health care regions (n = 57,066) were linked to the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) to identify women receiving RT who subsequently underwent a percutaneous coronary intervention (PCI) due to coronary stenosis. Cox regression analyses were performed to examine risk of a coronary intervention and competing risk analyses were performed to calculate cumulative incidence.

Results
A total of 649 women with left-sided breast cancer and 494 women with right-sided breast cancer underwent a PCI. Women who received left-sided RT had a significantly higher risk of a PCI in the left anterior descending artery (LAD) compared to women who received right-sided RT, hazard ratio (HR) 1.44 (95% confidence interval [CI] 1.21–1.77, p < 0.001). For the proximal, mid, and distal LAD, the HRs were 1.60 (95% CI 1.22–2.10), 1.38 (95% CI 1.07–1.78), and 2.43 (95% CI 1.33–4.41), respectively. The cumulative incidence of coronary events at 25 years from breast cancer diagnosis were 7.0% in women receiving left-sided RT and 4.4% in women receiving right-sided RT.

Conclusion
Implementing and further developing techniques that lower cardiac doses is important in order to reduce the risk of long-term side effects of adjuvant RT for breast cancer.
The role of the individual TOM subunits in the association of PINK1 with depolarized mitochondria
Authors: Maruszczak Klaudia K. , Jung Martin , Rasool Shafqat , Trempe Jean-François , Rapaport Doron 
Published: April 2022

Abstract
Mitochondria dysfunction is involved in the pathomechanism of many illnesses including Parkinson’s disease. PINK1, which is mutated in some cases of familial Parkinsonism, is a key component in the degradation of damaged mitochondria by mitophagy. The accumulation of PINK1 on the mitochondrial outer membrane (MOM) of compromised organelles is crucial for the induction of mitophagy, but the molecular mechanism of this process is still unresolved. Here, we investigate the association of PINK1 with the TOM complex. We demonstrate that PINK1 heavily relies on the import receptor TOM70 for its association with mitochondria and directly interacts with this receptor. The structural protein TOM7 appears to play only a moderate role in PINK1 association with the TOM complex, probably due to its role in stabilizing this complex. PINK1 requires the TOM40 pore lumen for its stable interaction with the TOM complex and apparently remains there during its further association with the MOM. Overall, this study provides new insights on the role of the individual TOM subunits in the association of PINK1 with the MOM of depolarized mitochondria.

Key messages

TOM70 is the main receptor for the import of PINK1 into mitochondria.

TOM20 plays only a minor role in PINK1 recognition at the organellar outer membrane.

PINK1 association with the TOM complex is reduced upon knock-down of TOM7.

The lumen of the TOM pore is crucial for PINK1 association with the outer membrane. TcPINK1 blocks the TOM pore in depolarized mitochondria.