bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personalized or unified approach in the prevention and treatment of oral mucositis in patients with malignant neoplasms of the head and neck organs: the choice of the optimal solution
Authors: Gvozdikova E. N. , Avanesov A. M. , Khalil E. F. , Kandakova E. Yu. , Avanesov K. A. 
Published: December 2022

Introduction. The prevalence of oncological diseases of the oropharyngeal region continues to grow steadily, but there is an increase for a number of nosologies in the five-year survival rate of this category of patients, which naturally leads to the actualization of accompanying treatment programs and the desire to improve the quality of life of oncological patients. One of the areas of maintenance therapy in oncology is dental support, the choice of approaches and methods of which is not systematically organized.Aim. To determine the optimal method of dental support for patients with malignant neoplasms of the head and neck organs for the prevention and treatment of oral mucositis.Materials and methods. At the Russian Scientific Center of Roentgenoradiology, retrospective analysis of scientific clinical results of oral mycosis treatment in patients with malignant tumors of the head and neck receiving antitumor therapy was performed.Results. Two main approaches have been identified for the prevention and treatment of oral mucositis in patients with malignant neoplasms of the head and neck organs: personalized and unified approach. using personalized approach, maximal mean value of oral mycosis severity during the whole antitumor treatment period per the Radiation therapy Oncology group (RTOg) classification was 2.19 ± 0.13. The quality of life of patients is reduced by 26.1 %. using unified approach, maximal mean value of oral mycosis severity during the whole antitumor treatment period per the RTOg classification was 2.44 ± 0.05. The quality of life of patients is reduced by 51.5 %, but at the same time, absolutely all patients retain the ability to eat independently and take care of the oral cavity.Conclusion. Both personalized and unified approaches for the prevention and treatment of oral mucositis are possible for use in clinical practice.
Evaluation of COVID-19 clinical features and outcomes in individuals with rheumatic disease
Authors: CENGİZ Gizem , ŞAŞ Senem 
Published: December 2022

features and course of coronavirus disease 2019 (COVID-19) in individuals with rheumatic disease.
Materials and Methods: This retrospective study was carried out at the Erciyes University rheumatology outpatient clinic from July 1 to August 1, 2021. The demographic and clinical data and summarized COVID-19 history, clinical course of COVID-19, fatigue, and pain levels of patients with rheumatic disease were obtained from our institutional electronic registration database and patient files.
Results: Recruited participants were 106 individuals (83% female, %17 male) with rheumatic disease who had been confirmed by laboratory tests to have COVID-19 and recovered from the COVID-19 infection. Their mean age and body mass index (BMI) were 48.69±11.5 years and 29.89±6.76 kg/m2, respectively. Additionally, 21 (19.8%) had been hospitalized, and five (4.7%) had been admitted to the intensive care unit. The most common rheumatic diseases were axial spondyloarthritis (40; 37.7%) and rheumatoid arthritis (26 cases; 24.5%). Patients who received conventional synthetic disease-modifying drugs (csDMARDs) reportedly experienced more pain, fatigue, and headaches than those in the biologic agent and non-steroidal anti-inflammatory drug (NSAID) groups.
Conclusion: Our study results reveal similar symptoms and hospitalization rates among patients with rheumatic disease who recovered from COVID-19 and received either csDMARDs, biologic agents, or NSAIDs. However, patients in the csDMARD group reported more pain, fatigue, and headache compared to the other groups.
Ganoderma lucidum inhibits proliferation and promotes autophagy in breast cancer cell lines with varying hormonal sensitivity by regulating Beclin-1, LC3, and p62
Authors: GÖKTEPE Özge , ÖNDER Gözde Özge , BOLAT Demet , ÇINAR Venhar , HAMURCU Zuhal , YAKAN Birkan , YAY Arzu 
Published: December 2022

Purpose: The aim of this study was to investigate the role of Ganoderma lucidum (GL) in cell proliferation and autophagy in breast cancer cell lines.
Materials and Methods: Cell lines were cultured in vitro and the appropriate dose was determined by the MTT method. In order to show the effect of GL on autophagy in MCF-7 and MDA-MB-231 breast cancer cell lines, Beclin-1, LC3 and p62 expression were examined by immunohistochemistry staining. Additionally, cell cycle analysis was carried out in GL-treated and untreated cells using a cell cycle analysis kit to look into how GL affects cell division.
Results: Viability level was significantly reduced in MCF-7 and MDA-MB-231 cells incubated with 40 and 80 μM concentrations of GL for 24 hours. In addition, GL induced the initiation of autophagy in MDA-MB-231 and MCF-7 cells, as evidenced by enhanced levels of Beclin-1, LC3 and p62 expression. At the same time, this study showed that GL induced cell cycle arrest in the G2/M phases.
Conclusion: GL has anti-proliferative activity by arresting the cell cycle at the G2/M phase and accelerates cell death by inducing autophagy, particularly in aggressive breast cancers that are resistant to treatment..
Students' Perspectives on Virtual Learning During The COVID-19 Pandemic
Authors: Hermansyah Hermansyah , Musahrain Musahrain , Ardianti Suji , Syafruddin Syafruddin 
Published: December 2022

Abstrak:Â Pembelajaran virtual merupakan proses belajar mengajar yang menggunakan media virtual berbantuan platform berbasis web. Penelitian deskriptif kuantitatif ini bertujuan untuk memperoleh gambaran pelaksanaan pembelajaran virtual online calon guru pada masa pandemic COVID-19. Penelitian ini dilakukan pada calon guru di Fakultas Keguruan dan Ilmu Pendidikan Universitas Samawa. Responden penelitian sebanyak 51 orang yang dipilih menggunakan teknik purposive sampling. Instrumen dalam penelitian ini menggunakan kuesioner berisi pertanyaan dan pernyataan yang berjumlah 13 item dengan satu kolom komentar yang disediakan diakhir. Angket tersebut menggambarkan tentang proses pembelajaran virtual online dari kesiapan infrastruktur sampai dengan prospek pembelajaran ini kedepan. Hasil penelitian diperoleh bahwa dari empat aspek yang diukur, mahasiswa calon guru memiliki pandangan positif tentang proses pembelajaran secara daring termasuk berkategori tinggi kecuali pada aspek kepraktisan. Dapat disimpulkan bahwa pembelajaran secara daring mempermudah mahasiswa dalam proses belajar dan sangat membantu mereka dalam menghindari pencemaran COVID-19.Abstract: Virtual learning is a teaching and learning process using virtual media assisted by a Web-based platform as a tool in the teaching and learning process. This quantitative descriptive study aims to obtain an overview of the implementation of virtual online learning for prospective teachers during the COVID-19 pandemic. This study was conducted on prospective teachers at the Faculty of Teacher Training and Education, Samawa University. The research respondents were 51 prospective teachers selected using the purposive sampling technique. The instrument in this study used a questionnaire containing questions and statements totaling 13 items with one comment column provided at the end. The questionnaires discuss the online virtual learning process, from infrastructure readiness to prospects for this learning. The study results showed that from the four aspects measured; teacher candidates had a view of the learning process being categorized as high except for the practical element. It can be concluded that online learning makes it easier for students in the learning process and helps them avoid contamination with COVID-19.Â
The influence of the Ini­tial Severity of Coronary Artery Lesion (by the Syntax Score) on the Midterm Prognosis of Patients With Acute Myocardial Infarction Without ST Segment Elevation
Authors: Rafaeli I. R. , Kireeva A. Iu. , Tsereteli N. V. , Rogatova A. N. , Semitko S. P. , Ioseliani D. G. 
Published: December 2022

Aim To study the effect of the baseline severity of coronary artery damage according to the SYNTAX scale (baseline score of coronary lesions, BSCL) on the mid-term prognosis in patients with non-ST segment elevation acute myocardial infarction (AMI) (NSTEMI), and to identify the threshold BSCL value that determines high and low risks of adverse cardiac outcomes.Material and methods A retrospective analysis was performed for the hospital treatment of patients with NSTEMI (n=421) who had undergone percutaneous coronary intervention (PCI). 256 patients with a repeated hospitalization in mid-term (11.6±3.2 months) were selected for the study. These patients were followed up for the incidence of acute coronary syndrome (ACS), unscheduled repeated myocardial revascularization (URR), and of the composite endpoint (CEP) that included at least one the following events: death, recurrent AMI, unstable angina (UA), and URR. The effect of BSCL on the incidence of these events in mid-term was proven (р<0.05), and then the BSCL threshold value was determined, which allowed segregation of patients into groups of high and low risk of adverse cardiac outcomes.Results The threshold BSCL value for the risk of ACS was determined as score 14 (odds ratio, OR, 2.79; 95 % confidence interval, CI: 1.32–5.89); for URR and CEP, score 13 (OR, 2.21; 95 % CI: 1.22–4.01 and OR, 2.38; 95 % CI: 1.32–4.31, respectively). Since these threshold values were comparable, for the composite category of events (CEP), the BSCL threshold comprised score 13, and namely this value was taken as a base. According to the multifactorial Cox regression at BSCL score ≥13, the probability of earlier CEP in mid-term was 2.44 times higher than at lower BSCL values (OR, 2.44; 95 % CI: 1.41–4.21; р=0.001). Furthermore, according to the Kaplan-Meier estimate, the effect of BSCL on the survival without adverse cardiac outcomes becomes significant starting from the second half-year (р=0.001, log-rank test).Conclusion In NSTEMI patients, the SYNTAX baseline score of coronary lesions >13 is an independent predictor of adverse cardiac outcomes in mid-term starting from the second half-year. Thus, patients with BSCL ≥13 should undergo a follow-up examination no later than at 6 months independent on their clinical condition..
TO THE QUESTION OF ETHNIC AND CIVIL POLITICAL IDENTITY OF CITIZENS OF MODERN KAZAKHSTAN
Authors: Kabaziev Manarbek Sh. 
Published: December 2022

Aim. To analyze the civil component in the political identity of modern Kazakhstan.Methodology. The civil ("Kazakh") and ethnic ("Kazakh") models of the formation of the political identity of the Republic of Kazakhstan are analyzed. The main approaches were constructivism and a systematic approach, which were used in relation to the analysis of political practice of modern Kazakhstan. The method of political modeling was also used.Results. The study revealed that in the process of constructing civil identity in Kazakhstan, a national myth is being created that employs several universal historical and political imperatives: the assertion of the the people and the Kazakh statehood’ antiquity, the imperative of the "age-old traditions" of the people, spiritual colonialism, and autarky. In the course of the study, the problems of the formation of a civil Kazakh nation were identified: the substitution of certain national components with ethnic and national ones).Research implications. The results of the study can be used both in the comparative analysis of the nation-building processes and the construction of political identity in other countries of the former USSR, as well as in predictive research regarding the political development of Kazakhstan.
Gestão escolar e oferta em extensões de matrícula da rede estadual de ensino do Ceará
Authors: Lima Ana Lea Bastos , Vieira Sofia Lerche , Vidal Eloisa Maia 
Published: December 2022

O artigo analisa a repercussão das ações do diretor escolar na gestão das turmas de extensão de matrícula de ensino médio da rede estadual de ensino do Ceará em cinco municípios e 21 distritos de diferentes regiões do estado. Trata-se de uma pesquisa qualitativa de natureza exploratória, a partir de um estudo de casos múltiplos. As fontes consistem em documentos oficiais, indicadores socioeconômicos, dados educacionais e informações coletadas durante a pesquisa de campo, a partir do roteiro de observação da infraestrutura e funcionamento das escolas e de entrevistas semiestruturadas com representantes da gestão da Secretaria Estadual de Educação, diretores, coordenadores escolares, professores, estudantes e pais/responsáveis. Os achados mostram que jovens residentes em localidades rurais têm o direito à educação assegurada pelo protagonismo de diretores, que incorporam à sua escola essas extensões e provocam os órgãos regionais e central a atuar para ajudar na implementação desta oferta. O Estado tem mostrado baixa capacidade de resposta a uma demanda antiga, o que leva a duas constatações: a invisibilidade de uma oferta que representa cerca de 17% das matrículas de ensino médio pública e a criação de um espaço de “negociação de balcão” em que a liderança de alguns diretores assegura melhores condições de atendimento, comprometendo o princípio republicano de igualdade de oportunidades para todos.
KEEFEKTIFAN KOLABORASI MODEL PEMBELAJARAN AIR DENGAN CRH BERBANTUAN VIDEO PEMBELAJARAN TERHADAP PEMAHAMAN KONSEP MATEMATIKA
Authors: Wulandari Nur Indri , Mardhiyana Dewi 
Published: December 2022

This study aims to: (1) determine the average ability to understand mathematical concepts of students who are taught using the collaborative learning model AIR (Auditory, Intellectual, Repetition) with CRH (Course Review Horay) assisted by video learning is better than the average understanding of mathematical concepts students who are taught using conventional learning models, (2) knowing the average mathematical concept understanding ability of students who use the AIR (Auditory, Intellectual, Repetition) collaborative learning model with CRH (Course Review Horay) assisted by learning videos to achieve the Minimum Completeness Criteria (KKM). This research is a quantitative research with experimental method. The population of this study were all eighth grade students of MTs Nurul Huda Banyuputih in the even semester 2021/2022 academic year. Data collection was carried out using the test method. The data obtained were analyzed by t test and Z test. The results showed: (1) the average mathematical concept understanding ability of students who are taught using the AIR collaboration model with CRH assisted by video learning is better than the average understanding of mathematical concepts of students who are taught using the model conventional learning, (2) the proportion of students taught using the AIR collaboration model with CRH assisted learning video gets a score of more than 75%.
SOCIAL IMPACT ANALYSIS OF MASS COMMUNICATION ON COMMUNITY IN THE SOCIETY 5.0 ERA
Authors: Siti Wuryan  , Mustofa Muhamad Bisri , Rezha Mardianty Rachmy  , Sarah Nur Laila Indriyani  , Septi Jelita Putri  , Tri Yana Dea Sari  
Published: December 2022

The Society 5.0 era is considered a phenomenon of combining cyber technology with automation technology, which is characterized by changes in various sectors. In this case, mass communication is system communication that is carried out through mass media and has a significant impact, especially in its application in everyday life with diverse impacts. This research uses qualitative methods while using a library research approach. The results of observations and literacy studies conducted by the author concluded that mass communication has a considerable social impact on society along with technological developments. Because the media plays a big role in the method of replacing existing social norms with new ones, even changing and creating new ones.
Effect of yeast concentration and fermentation time on the characteristics of tuak from coconut sap
Authors: Gunam Ida Bagus Wayan , Kaban Thobie E. B , Suwariani Ni Putu 
Published: December 2022

Tuak is a traditional fermented drink made from the sap of the Palmae family that is favored by rural communities. The quality of tuak varies greatly and depends on the type of microbe that contaminates the sap raw material. This research aimed to get the best yeast concentration and fermentation time, to get the best characteristics of tuak from coconut sap. The first factor was yeast concentration (0, 2, 4, 6, and 8%). The second factor was fermentation time (24, 48, 72, 96, and 120 hours). The research was grouped based on the processing time and got 50 units of the samples. The experiment was carried out at room temperature (± 30°C). The parameter of this research was sensory evaluation test, alcohol content, pH, total dissolved solids, and total sugar. The data of this research were analyzed with analysis of variance, followed by the Duncan’s test. The results showed that yeast concentration 4% w/v and fermentation time of 72 hours produced the best characteristics of tuak from coconut sap with the characteristics of sensory test for the alcohol flavor was between like to really like (4.30), the sour flavour was neutral to like (3.59), the sweet flavour was like to really like (4.85), and overall acceptance was like to really like (4.95) with alcohol content (9.38%), pH (4.2), total dissolved solids (7.52 mg/L) and total sugar (1.54%). The addition of starter culture can speed up the fermentation process and at the same time improve the quality of tuak from coconut sap.
Disposable Diaper Product Packaging Design (POCA)
Authors: Kurniawan Firman , Abadi Totok Wahyu , Fikri Andi , Febriana Poppy , Aesthetika Nur Maghfirah , Yani Muhammad 
Published: December 2022

Desain kemasan berlaku untuk, melindungi, mengirim, mengeluarkan, menyimpan, mengidentifikasi, dan membedakan sebuah produk dipasar. Pada akhirnya desain kemasan berlaku sebagai kemasan sebagai pemasaran produk dengan mengkomunikasikan kepribadiaan atau fungsi produk konsumsi secara unik. Packaging adalah pembungkus yang digunakan untuk melindungi barang dagangan, hasil produksi, dan sebagainya. Namun, kini maknanya lebih luas lagi, karena packaging tidak hanya untuk melindungi barang/isinya, melainkan juga untuk menyampaikan kepada konsumen alasan yang paling menarik dan tak terbantahkan agar membeli sebuah produk. Sadar Popok Merupakan sebuah program yang di bangun oleh Universitas muhammdiyah Sidoarjo dari Prodi Ilmu Komunikasi dan juga Management. Untuk mengembangkan Sadar Sampah popok sekali Pakai (POSPAK) melalui analisis perilaku dan Strategi Intregrated Marketing Communication. Bukan hanya itu Sadar Popok juga merupakan target untuk Masyarakat agar mengurangi Limbah Popok Sekali Pakai. POCA adalah sebuah singkatan dari POPOK CUCI PAKAI merupakan sebuah Merk/ Brand dipergunakan untuk mengenal Standarisasi identitas Visual Yang dimiliki POCA
The Effect of Intellectual Capital and Good Corporate Governance on Firm Value with Financial Performance as an Intervening Variable
Authors: Septiawan Fahrizal , Hermawan Sigit 
Published: December 2022

This study aims to determine the effect of intellectual capital and good corporate governance on firm value with financial performance as an intervening variable in High-IC Intensive companies listed on Indonesia Stock Exchange (IDX) in 2016-2019. The population in this study are Construction companies listed on the Indonesia Stock Exchange in 2016-2019. The sampling technique used in this research is purposive sapling. The analytical technique used in the research is Partial Least Square (PLS). The result of this study indicate that intellectual capital has no effect on financial performance. Good corporate governance has no effect on financial performance. Intellectual capital affects the value of the firm value. Good corporate Governance affects the value of the firm value. Fienancial performance has no effect on firm value. Financial performance is not able to mediatethe relationship between intellectual capital and firm value. Financial performance is not able to mediatethe relationship between good corporate governance and firm value.
Digital production of an occlusal splint by a jaw movement analysis system and an average articulator: A preliminary study
Authors: Ren Guanghui , Peng Tiwu , Ma Teng , Yang Zhikang 
Published: December 2022

Abstract
Aims To evaluate and compare the clinical efficacy and the volume of occlusal adjustment of digital occlusal splints designed using an average digital articulator and the Jaw Movement Analysis System (JMAS).
Materials and methods A digital impression was taken intraorally from the maxillary and mandibular dentition and from the maxillomandibular relationship record in the centric relation position. Two pairs of occlusal splints were designed, one using an average digital articulator and the other using a digital articulator whose parameters were adjusted by the JMAS. Comparing the position and volume of adjustment of each occlusal splint before and after adjustment, and to subjectively evaluate the clinical efficacy of the occlusal splints.
Results The subjective scores of the occlusal splints made using the average articulator parameters and the JMAS were 9 and 11, respectively. The objective evaluation of the occlusal splints revealed that the RMS value of the average occlusal splint was 0.1932 mm, while that of the customized occlusal splint was 0.1015 mm.
Conclusions The occlusal splints made with the assistance of the JMAS had a lower volume of occlusal adjustment. The two occlusal splints fulfilled all clinical requirements.
Resorption as a complication of overlay orthodontic treatment: a literature review
Authors: -Sobotka Monika Tymczyna , Mikulska² Monika , Baran² Gabriela 
Published: December 2022

Abstract
Background
The aim of this study was to assess the severity of apical root resorption of tooth roots after orthodontic treatment with aligners. An attempt was made to compare resorption of tooth roots after aligner and conventional fixed appliances treatment and to determine the relationship between the duration of treatment and the degree of resorption. The influence of orthodontic forces on the occurrence of root resorption was also assessed.
Material and methods
The PubMed database, GoogleScholar and Access Medicine, Dentistry and Oral Sciences Source, Scopus, and Web of Science were used for the study using the keywords: apical root resorption, resorption, aligners, orthodontic resorption. Mainly retrospective studies, meta - analyses and systematic reviews were analysed. A total number of 20 literature items were used.
Results
Root resorption is evident after treatment with aligners, but most studies indicate that it is less advanced than after treatment with fixed braces. According to different authors, it averages from 0.25mm to 2.5mm. Shorter aligner treatment and intermittent forces on the teeth appear to reduce the degree of resorption.
Conclusion
Analysed suggest that the degree of root resorption occurring after aligner treatment is low. Although the review included a significant number of studies or in comparison to fixed appliance treatment further prospective studies are needed. It will be important perform study to observe malocclusions of similar severity treated with aligners and fixed appliances considering all stages of treatment.