bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inferred Properties of Planets in Mean-motion Resonances are Biased by Measurement Noise
Authors: Jensen David , Millholland Sarah C. 
Published: September 2022

Abstract
Planetary systems with mean-motion resonances hold special value in terms of their dynamical complexity and their capacity to constrain planet formation and migration histories. The key toward making these connections, however, is to have a reliable characterization of the resonant dynamics, especially the so-called “libration amplitude,” which qualitatively measures how deep the system is into the resonance. In this work, we identify an important complication with the interpretation of libration amplitude estimates from observational data of resonant systems. Specifically, we show that measurement noise causes inferences of the libration amplitude to be systematically biased to larger values, with noisier data yielding a larger bias. We demonstrated this through multiple approaches, including using dynamical fits of synthetic radial velocity data to explore how the libration amplitude distribution inferred from the posterior parameter distribution varies with the degree of measurement noise. We find that even modest levels of noise still result in a slight bias. The origin of the bias stems from the topology of the resonant phase space and the fact that the available phase-space volume increases nonuniformly with increasing libration amplitude. We highlight strategies for mitigating the bias through the usage of particular priors. Our results imply that many known resonant systems are likely deeper in resonance than previously appreciated.
Formation and Morphology of the First Galaxies in the Cosmic Morning
Authors: Park Changbom , Lee Jaehyun , Kim Juhan , Jeong Donghui , Pichon Christophe , Gibson Brad K. , Snaith Owain N. , Shin Jihye , Kim Yonghwi , Dubois Yohan , Few C. Gareth 
Published: September 2022

Abstract
We investigate the formation and morphological evolution of the first galaxies in the cosmic morning (10 ≳ z ≳ 4) using the Horizon Run 5 (HR5) simulation. For galaxies above the stellar mass

M

⋆
,
min

=
2
×

10

9

M

⊙

, we classify them into disk, spheroid, and irregular types according to their asymmetry and stellar-mass morphology. We find that about two-thirds of the galaxies have a Sérsic index <1.5, reflecting the dominance of disk-type morphology in the cosmic morning. The rest are evenly distributed as incidental and transient irregulars or spheroids. These fractions are roughly independent of redshift and stellar mass up to ∼1010
M
⊙. Almost all the first galaxies with

M

⋆

>

M

⋆
,
min

at z > 4 form at initial peaks of the matter-density field. Large-scale structures in the universe emerge and grow like cosmic rhizomes as the underlying matter-density fluctuations grow and form associations of galaxies in rare overdense regions and the realm of the galactic world is stretched into relatively lower-density regions along evolving filaments. The cosmic web of galaxies forms at lower redshifts when most rhizomes globally percolate. The primordial angular momentum produced by the induced tidal torques on protogalactic regions is correlated with the internal kinematics of galaxies and tightly aligned with the angular momentum of the total galaxy mass. The large-scale tidal field imprinted in the initial conditions seems responsible for the dominance of disk morphology and for the tendency of galaxies to reacquire a disk postdistortion.
Reconstruction of Coronal Magnetic Fields Using a Poloidal–Toroidal Representation
Authors: Yi Sibaek , Choe G. S. , Cho Kyung-Suk , Solanki Sami K. , Büchner Jörg 
Published: September 2022

Abstract
A new method for reconstruction of coronal magnetic fields as force-free fields (FFFs) is presented. Our method employs poloidal and toroidal functions to describe divergence-free magnetic fields. This magnetic field representation naturally enables us to implement the boundary conditions at the photospheric boundary, i.e., the normal magnetic field and the normal current density there, in a straightforward manner. At the upper boundary of the corona, a source surface condition can be employed, which accommodates magnetic flux imbalance at the bottom boundary. Although our iteration algorithm is inspired by extant variational methods, it is nonvariational and requires far fewer iteration steps than most others. The computational code based on our new method is tested against the analytical FFF solutions by Titov & Démoulin. It is found to excel in reproducing a tightly wound flux rope, a bald patch, and quasi-separatrix layers with a hyperbolic flux tube.
Adalimumab Biosimilar Efficacy and Safety in a 5-Year-Old Patient with Severe Plaque Psoriasis During SARS-CoV-2 Pandemic Outbreak
Authors: Gallo Lucia , Capasso Gianmarco , Nastro Francesca , Fabbrocini Gabriella , Megna Matteo 
Published: September 2022

BACKGROUND: Psoriasis is a chronic inflammatory disease that affects 2% of population. About 0.5–2% of psoriatic cases develop during pediatric age. In most cases, the condition is responsive to topical treatment. However, a small percentage of children require systemic treatment with conventional systemic drugs or biological agents, such as anti-tumor necrosis factor (TNF)-α. Adalimumab (ADA) is an anti-TNF-α recently approved for pediatric psoriasis in the European Union (from 4 years of age, 2015).

CASE PRESENTATION: We describe our experience treating a 5-year-old female patient affected by severe plaque psoriasis with ADA biosimilar during SARS-CoV-2 pandemic outbreak also using teledermatology.

CONCLUSION: The case reported in this article highlights the safety and the effectiveness of ADA biosimilar MSB11022 (Idacio®) in the treatment of a 5-year-old female affected by plaque psoriasis and paves the way to bigger trials for a more extensive use of TNF-α inhibitor biosimilars for psoriasis in pediatric population.
From Biodiversity Observation Networks to Datasets and Workflows Supporting Biodiversity Indicators, a French Biodiversity Observation Network (BON) Essential Biodiversity Variables (EBV) Operationalization Pilot using Galaxy and Ecological Metadata Language
Authors: Royaux Coline , Norvez Olivier , Jossé Marie , Arnaud Elie , Sananikone Julien , Pavoine Sandrine , Pelletier Dominique , Mihoub Jean-Baptiste , Le Bras Yvan 
Published: September 2022

Integration of biological data with different ecological scales is complex! The biodiversity community (scientists, policy makers, managers, citizen, NGOs) needs to build a framework of harmonized and interoperable data from raw, heterogeneous and scattered datasets. Such a framework will help observation, measurement and understanding of the spatio-temporal dynamic of biodiversity from local to global scales. One of the most relevant approaches to reach that aim is the concept of Essential Biodiversity Variables (EBV). As we can potentially extract a lot of information from raw datasets sampled at different ecological scales, the EBV concept represents a useful leverage for identifying appropriate data to be collated as well as associated analytical workflows for processing these data.
Thanks to FAIR data and source code implementation (Findable, Accessible, Interoperability, Reusable), it is possible to make a transparent assessment of biodiversity by generating operational biodiversity indicators (that can be reused / declined) through the EBV framework, and help designing or improving biodiversity monitoring at various scales.
Through the BiodiFAIRse GO FAIR implementation network, we established how ecological and environmental sciences can benefit from existing open standards, tools and platforms used by European, Australian and United States infrastructures, particularly regarding the Galaxy platform for code sources accessiblility and the DataOne network of data catalogs and the Ecological Metadata Language standard for data management. We propose that these implementation choices can help fight the biodiversity crisis by supporting the important mission of GEO BON (Group on Earth Observation Biodiversity Observation Network): “Improve the acquisition, coordination and delivery of biodiversity observations and related services to users including decision makers and the scientific community” (GEO BON 2022).
A case of frozen behaviour: A flat wasp female with a beetle larva in its grasp in 100-million-year-old amber
Authors: Kiesmüller Christine , Haug Joachim T. , Müller Patrick , Hörnig Marie K. 
Published: September 2022

Parasitism, a malignant form of symbiosis, wherein one partner, the parasite, derives benefits to the detriment of another, the host, is a widespread phenomenon. Parasitism sensu lato is understood here to include many phenomena, like parasitoidism, kleptoparasitism, phoresy and obligate parasitism. Insecta has many in-groups that have evolved a parasitic life-style; one of the largest in-groups of these is probably the group of Hymenoptera. Bethylidae, the group of flat wasps, is a smaller in-group of Aculeata, the group of hymenopterans with venom stings; representatives of Bethylidae are parasitic. They are more specifically larval ectoparasitoids, meaning that their immature stages are externally developing parasites that kill their host organism at pupation (end of interaction). They mostly parasitise immature representatives of Coleoptera and Lepidoptera. Female flat wasps search for a host for their progeny, paralyse it with their venom sting and then oviposit onto it.Herein we describe one of the oldest findings of parasitic interactions of parasitoid wasps with their progenies’ hosts, specifically a flat wasp female grasping and (potentially) stinging a beetle immature in Cretaceous Kachin (Myanmar) amber (ca. 100 million years old). This finding indicates that this type of parasitic interaction existed since the Cretaceous, temporally close to the earliest findings of representatives of Bethylidae.
Urban ecosystems and heavy rainfall – A Flood Regulating Ecosystem Service modelling approach for extreme events on the local scale
Authors: Wübbelmann Thea , Bouwer Laurens , Förster Kristian , Bender Steffen , Burkhard Benjamin 
Published: September 2022

Increasing urbanisation in combination with a rise in the frequency and intensity of heavy rain events increase the risk of urban flooding. Flood Regulating Ecosystem Services (FRES) address the capacity of ecosystems to reduce the flood hazard and lower damage. FRES can be estimated by quantification of supply (provision of a service by an ecosystem) and demand (need for specific ES by society). However, FRES for pluvial floods in cities have rarely been studied and there is a gap in research and methods on FRES supply and demand quantification.
In this study, we assessed FRES of an urban district in the City of Rostock (Germany) for a one-hour heavy rainfall event using the hydrological model LEAFlood. The hydrological model delivered the FRES supply indicators of soil water retention and water retained by canopies (interception). An intersection of the potential demand (based on indicators of population density, land reference value, monuments and infrastructure) and the modelled surface water depth revealed the actual demand. Comparing the actual demand and supply indicated the budget of FRES to identify unmet demand and supply surplus.
Results show highest mean FRES supply on greened areas of forests, woodlands and green areas, resulting in a supply surplus. Whereas, sealed areas (paved surface where water cannot infiltrate into the soil), such as settlements, urban dense areas, traffic areas and industry, have an unmet demand resulting from low supply and relatively high actual demand.
With the hydrological model LEAFlood, single landscape elements on the urban scale can be evaluated regarding their FRES and interception can be considered. Both are important for FRES assessment in urban areas. In contrast to flood risk maps, the study of FRES gives the opportunity to take into account the contribution of nature to flood regulation benefits for the socio-economic system. The visualisation of FRES supply and demand balance helps urban planners to identify hotspots and reduce potential impacts of urban pluvial flooding with ecosystem-based adaptations.
Chapitre 2. La réglementation en matière de logement social
Authors: Brouant Jean-Philippe 
Published: September 2022

Afin de préciser le rôle respectif de chacun dans la « chaîne du logement », on retient traditionnellement trois secteurs d’intervention. Le premier recouvre la programmation du logement, c’est-à-dire à la fois la définition d’objectifs, de priorités et les modalités de réalisation de ces objectifs. Le deuxième secteur d’intervention constitue, d’une façon globale, la réalisation des objectifs en termes de financement. Enfin, au bout de la « chaîne du logement », se trouvent les éléments relatifs à la gestion des logements sociaux, à savoir les politiques de peuplement. Analyser dans le détail la réglementation du logement social et sa mise en œuvre répond à un objectif audacieux. Il impliquerait une enquête lourde sur la mise en œuvre réelle des compétences et les mécanismes qui dépasse les compétences du juriste. L’étude s’est néanmoins appuyée sur l’analyse de certains documents locaux qui permettent de dégager des traits généraux sans prétendre à la fixation de constats définitifs. De plus ont été prises en compte les expériences sur sites menées par les associations régionales HLM.
L’inclusion des « personnes handicapées » au Nord Cameroun
Authors: Talikoa Amada 
Published: September 2022

Le propos de cette réflexion porte sur l’encadrement et la gestion du handicap chez les peuples Podoko du Nord Cameroun. Il s’agit d’examiner les approches sociales développées par ce groupe pour l’épanouissement des personnes en situation de handicap. Comment la société Podoko se représente-t-elle le handicap et comment travaille-t-elle à l’accomplissement de la personne handicapée ? L’étude a adopté une combinaison de démarches socio--historique et ethnographique articulant les récits de vie et les observations.
Effect of different mechanical ventilation modes on cerebral blood flow during thoracoscopic surgery in neonates: A randomised controlled trial
Authors: Abdallah Nasr M. , Elela Amel H. Abo , Maghawry Hossam H. , Alkonaiesy Ramy M. 
Published: September 2022

Background and Aims:
Infants exposed to major surgery are at risk of injuries to the immature brain because of reduced arterial oxygen saturation. This study compared the effect of volume-controlled ventilation (VCV) versus pressure-controlled ventilation (PCV) on cerebral oxygenation in neonates subjected to repair of tracheoesophageal fistula (TEF) under video-assisted thoracoscopic surgery (VATS).

Methods:
This randomised controlled study included 30 full-term neonates scheduled for VATS for managing TEF under general anaesthesia. They were randomised to either VC group (n = 15), who received VCV, or PC group (n = 15), who received PCV. Cerebral oxygenation (rScO2) was monitored throughout the surgery with documentation of episodes of cerebral desaturation. Peripheral oxygen saturation, partial pressure of carbon dioxide (PaCO2), and end-tidal carbon dioxide were recorded at baseline, after induction of anaesthesia, and every 30 min till the end of the surgery.

Results:
rScO2 was significantly higher in the PC group than the VC group at baseline and was significantly higher in the VC group after 15 min (P = 0.041). Later, it was comparable in both the groups up to 60 min after starting the surgery. Cerebral desaturation was significantly more common in the PC group (80%) compared to VC group (33.3%) (P = 0.010). PC group required higher fraction of inspired oxygen and positive end-expiratory pressure to prevent cerebral desaturation. PaCO2 was significantly higher in the PC group than the VC group at 30 and 60 min (P = 0.005 and 0.029).

Conclusion:
VCV is safer than PCV for cerebral oxygenation during VATS in neonates.
Risk of self-contamination because of improper doffing of personal protective equipment: A randomised cross-over study
Authors: Sahay Nishant , Naaz Shagufta , Singh Prabhat K , Kumar Rajesh , Ranjan Alok , Vivekanand  
Published: September 2022

Background and Aims:
Many health care staff have been pressed into coronavirus disease-19 patient care with little experience of working in bio-hazard zones because of the overwhelming requirements of manpower. They wear personal protective equipment (PPE) and follow all rules for their safety. However, despite precautions, during doffing, they carry a risk of self-contamination. This randomised cross-over study assessed the risk of self- contamination because of improper doffing of PPEs.

Methods:
A colourless lotion that glows with a bright-green fluorescent hue under ultraviolet light was applied to simulate germ contamination in various health care workers (HCWs) who volunteered for the study. The primary objective of this study was to know the percentage of HCWs getting self-contaminated. The secondary objectives were to assess which portions of the body get maximally contaminated and infestation of germs on which portions of the PPE carry more risk of self-contaminating after doffing.

Results:
A total of 152 doffings by 76 participants were analysed, and the volunteers self-contaminated in 43 doffings (28.28%). In 18 of these 43 doffings, self-contamination was noted at more than one location. The most commonly contaminated areas were the arms (33%), clothes on the abdomen (24%), and areas in the lower limb (23%). Germ infestation on the upper parts of a PPE is 2.39 times more likely to cause self-contamination after improper doffing.

Conclusion:
Faulty doffing resulted in self-contamination in 28.28% of all doffings. Risk is 2.39 times more when germs are nested in the upper body portions of the PPE suit.
Evaluation of the electronic stethoscope (FONODOC) as a cardiac screening tool during the preoperative evaluation of children
Authors: Ahuja Vasudha , Kini Priyanka , Nileshwar Anitha 
Published: September 2022

Background and Aims:
An electronic stethoscope with an inbuilt phonocardiogram is a potentially useful tool for paediatric cardiac evaluation in a resource-limited setting. We aimed to compare the acoustic and electronic stethoscopes with respect to the detection of murmurs as compared to the transthoracic echocardiogram (TTE).

Methods:
This was an observational study. Fifty children aged 0–12 years with congenital heart diseases (CHDs) and 50 without CHD scheduled for echocardiography were examined using both stethoscopes. The findings were corroborated with clinical findings and compared with the echocardiography report.

Results:
Among the 50 cases without CHD, no murmur was detected using either of the stethoscopes. This was in agreement with TTE findings. The calculated specificity of both stethoscopes was 100%. Amongst the 50 cases with CHD, the electronic stethoscope picked up murmurs in 32 cases and missed 18 cases. The acoustic stethoscope picked up murmurs in 29 cases and missed 21 cases. Thus, the sensitivity of electronic and acoustic stethoscopes as compared to TTE was calculated to be 64% and 58%, respectively. The positive predictive value of the electronic stethoscope as compared to TTE was 100% while the negative predictive value was 73%. The kappa statistic was 0.93 suggesting agreement in 93%. Mc-Nemar’s test value was 0.24 suggesting that the electronic stethoscope did not offer any advantage over the acoustic stethoscope for the detection of CHD in children.

Conclusion:
A comparison of the electronic stethoscope with an acoustic stethoscope suggests that the rate of detection of CHD with both stethoscopes is similar and echocardiography remains the gold standard.
Can clinical parameters of patients, sans serum prolactin measurement, identify amenorrhea associated with risperidone use? Results from a cross-sectional analytical study
Authors: Chandrasekaran Vigneshvar , Muthuramalingam Avin , Subramanian Karthick 
Published: September 2022

Background:Risperidone is a second-generation antipsychotic, which exerts its action by antagonizing dopamine (D2) and serotonin (5-HT2A) receptors. Amenorrhea is a common adverse effect observed in risperidone. Risperidone blocks the dopamine receptor of lactotroph cells of the pituitary gland, resulting in loss of the inhibitory effect of dopamine on prolactin. The resultant hyperprolactinemia decreases estrogen through its impact on the pulsatile secretion of gonadotropins and ovarian follicular growth leading to amenorrhea. Identifying the associated clinical parameters will aid in predicting the occurrence of amenorrhea in patients on treatment with risperidone, especially in a setting devoid of prolactin estimation. The objective of this study was to compare the clinical profile of patients with and without risperidone-induced amenorrhea.Methodology:A cross-sectional comparative study was done in a tertiary care hospital. A total of 30 female patients on risperidone who developed amenorrhea were recruited, and age-matched patients on risperidone without amenorrhea were taken as controls. The clinical parameters of the groups were compared using the Mann–WhitneyU-test. Binary logistic regression was used to predict the clinical predictors associated with risperidone-induced amenorrhea.Results:The amenorrhea group had a significantly longer duration of untreated psychosis (DUP) (P= 0.011), duration of total treatment (P= 0.003), and duration of treatment exclusively with risperidone (P= 0.002). No significant differences were noted in the dose of risperidone (P= 0.570) and the diagnosis (P= 0.455) between the groups. However, the regression test did not confer any risk due to any clinical parameters.Conclusion:Individuals who developed amenorrhea had a longer DUP and a longer duration of treatment exclusively with risperidone.
Anxiety Perception Among Children Following Two Different Restorative Modalities – A Noninferiority Randomized Clinical Trial
Authors: Hemalatha R. , Nirmala S. , Viswaja K. 
Published: September 2022

Background:
Anxiety perception among children plays a significant part in providing oral health care since both are interlinked. Perception refers to the ways or means by which anything is perceived or interpreted. Perception is awareness of the elements of the environment through physical sensation. As part of oral health-care initiation, the present study aimed to compare the anxiety perception among children following two different restorative modalities of atraumatic restorative treatment versus chemomechanical caries removal (CMCR).

Methodology:
A nonrandomized clinical trial was conducted over 2 months between February 20, 2021 and April 22, 2021, to compare the anxiety perception among children. Children below 14 years were selected for the study purpose.

Results:
Poisson regression analysis was used to evaluate the association between outcome and the variables. The results showed that the majority of children had dental anxiety issues, who were willing to improve their cooperative levels during dental treatment appointments. No statistically significant association was seen between the two different restorative modalities. Lower heart rate was observed when CMCR was used (P = 0.013).

Conclusion:
Anxiety perception among children plays a significant part in providing oral health care. The effectiveness of implementation was appropriate with regard to choosing the right treatment modalities among clinicians. Both the techniques showed minimal or lesser anxiety levels, but on a comparative note, CMCR was better, both in terms of patient acceptance and ease of performance.