bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring pharmaphylogeny from multiple perspectives: A case study on Lithospermeae
Authors: Yan Yumei , Wei Xinxin , Qiu Bin , Wang Guoping , Zhou Baochang , Zhang Mingxu , Liu Yibo , Li Siqi , Gao Bowen , Li Minhui 
Published: August 2022

Abstract
Lithospermeae, a tribe under the subfamily Boraginoidae, is a perennial herb containing about 470 species under 26 genera, mainly distributed in temperate and tropical regions. To gain a deeper understanding of the medicinal plants of Lithospermeae and better protect and develop plant medicinal resources, the phytochemistry, pharmacology, and traditional use of Lithospermeae with medicinal value were analyzed. Phylogenetic analysis was carried out based on the internal transcribed spacer (ITS) sequence. Through spatial analysis and the species distribution model, the spatial distribution pattern of Lithospermeae medicinal plants was analyzed. At the same time, the relevant targets and pathways involved in the pharmacological effects of commonly used medicinal plants were predicted using network pharmacology to further explore the genetic origin of Lithospermeae and enrich the pharmaphylogeny of medicinal plants. In this study, the chemical composition, traditional efficacy, modern pharmacological activity, geographical distribution model, molecular phylogeny, and network pharmacology of Lithospermeae were analyzed for the first time. Based on our findings, the pharmaphylogeny of Lithospermeae was preliminarily discussed, providing the scientific basis for basic research regarding Lithospermeae. At the same time, this study explored the relationship between the development of the regional medicinal plant industry and the protection of biodiversity. Furthermore, our findings provide direction and theoretical guidance for the study of the phylogenetic relationships in medicinal plants and the development of Lithospermeae medicinal plant resources.
Shortening L-DOPA testing time in the diagnosis of growth hormone deficiency: is it possible?
Authors: Castelli Barbara , De Santis Rita , Carrera Simona Gilda , Stagi Stefano 
Published: August 2022

Abstract
Introduction: Growth hormone deficiency (GHD) diagnosis in childhood is based on clinical and auxological assessment, combined with biochemical tests, but the reliability of pharmacological provocative tests in diagnosing GHD in children remains disputed. In recent years several papers have been published on standardizing the duration of the test for some stimuli. The aim of our study is to analyze the L-DOPA test, evaluating whether it is possible to shorten it to 90 minutes, without changing its validity, to reduce healthcare costs and patient’s discomfort.Methods: In a retrospective study, we investigated the response of Growth Hormone (GH) to L-DOPA test in 256 children (147 males, 109 females, 177 prepubertal, 79 puberal), analyzing a total of 267 L-DOPA test performed. The inclusion criteria were height less than -2 SD below the mean for the normal population and/or a subnormal growth velocity. Exclusion criteria were genetic, oncological, or neurological diseases. Based on the results of the stimulation tests, we divided the patients into two groups: patients with diagnosis of GHD (two different deficient provocative tests carried out in two different occasions), and patients with idiopathic short stature (ISS), who satisfied auxological criteria presenting at least one normal response to provocative tests. We analyzed the same data considering GH peak threshold value both at 8 ng/ml (value considered as the cut-off in Italy) and at 10 ng/ml (international cut-off for the diagnosis of GHD). We first described the results in the whole population and then clustering the population for gender and pubertal stage.Results: With a GH threshold value of 8 ng/ml, shortening L-DOPA test time from 120 to 90 minutes would have changed test results in 7 of the 267 analyzed tests (2.62%). With a GH threshold for the diagnosis of GHD at 10 ng/ml, shortening L-DOPA test time from 120 to 90 minutes would have changed test results in 3 of the 267 analyzed tests (1.12%).Conclusion: The L-DOPA test can be administered for 90 minutes without significantly changing its validity to minimize patient discomfort and healthcare costs.
Smart Water Heater System Monitoring And Controlling Using Arduino Board
Authors: Elnour Khalifa Dai 
Published: August 2022

Abstract
Smart water heating systems have become an important topic in all applications, especially industrial applications with a wide range of efficient temperatures. The system basically includes a voltage regulator, a dry resistor, a temperature sensor, an LCD, a relay, a heater, and a microcontroller. The temperature difference on the surface of the processor allows for rapid heat storage. Arduino UNO is used to regulate voltage, sense temperature and make production. The concept of draft is devised, created and evaluated. After adjusting the temperature to various levels and checking the final output, the heater turned on / off when the unit exceeded the set value. Therefore, the temperatures in cold and hot regions are more efficient at reaching thermal equilibrium as the water rises.
Biochemical and Microbiological Aspects of the Oral Cavity of Children and Young People With Neurological Impairment and Oropharyngeal Dysphagia
Authors: Duarte Janaina Costa Marangon , Costa Isabela Bazzo , Teixeira Daniel De Bortoli , Fregatto Luiz Fernando , Mendes Claudemir Gregorio , Mascarin Aline Maria Noli , Junior Salum Bueno da Silveira , Serva Bianca Eduarda Baptistella Mesquita , Comar Livia Picchi , Silva Roberta Gonçalves da , Junior Francisco Agostinho , Cola Paula Cristina 
Published: August 2022

Abstract
Background
The components and the salivary flow have a direct influence on the composition of the oral microbiota of children and young people with oropharyngeal dysphagia, studies have already demonstrated excessive accumulation of supragingival dental calculus in individuals with enteral nutrition. This study aimed to compare the oral hygiene, biochemical, and microbiological aspects of the oral cavity of children and young people with neurological impairment and oropharyngeal dysphagia.
Methods
Forty children and young people with neurological impairment and oropharyngeal dysphagia were enrolled and divided into two groups: group I, including 20 participants fed via gastrostomy; and group II, including 20 participants fed via the oral route. Oral hygiene and salivary pH and flow were assessed, and polymerase chain reaction was performed to evaluate the messenger RNA expressions of Porphyromonas gingivalis, Tanerella forsythia, and Treponema denticola.
Results
In groups I and II, the mean Oral Hygiene Index - Simplified scores were 4 and 2, respectively, showing a significant difference; the mean Calculus Index scores were 2 and 0, respectively, showing a significant difference; and the mean pH was 7.5 and 6.0, respectively, showing a significant difference. Bacterial analysis indicated no association between the two groups.
Conclusion
Children and young people who use gastrostomy had a poorer oral hygiene, greater dental calculus deposition, and higher salivary pH. Saliva of patients in both groups contained Porphyromonas gingivalis, Tanerella forsythia, and Treponema denticola.
A novelty mandrel supported thin-wall tube bending cross-section quality analysis: a diameter-adjustable multi-point contact mandrel
Authors: Li Jie , wang zili , Zhang Shuyou , Lin Yaochen , Wang Le , Sun Chang , Tan Jianrong 
Published: August 2022

Abstract
The mandrel plays a vital role in metal tube bending limit improvement and high-quality achievement. For the bending forming process of metal tubes with different diameters, the corresponding mandrel needs to be customized, which has the disadvantages of a long design cycle, high manufacturing cost, and low reuse rate. To tackle this issue, a novelty concept of diameter adjustable mandrel (DAM) based on the multi-point contact was put forward to adapt different diameters tubes bending processes. Since the point-contact characteristics of the DAM can lead to irregular cross-section deformation, the cross-sectional full profile radial error (FP-RE) model was proposed as a more comprehensive evaluation model to measure the deformation degree of the whole bending cross-section. A diameter-adjustable DAM was adopted in the AISI 304L tubes (the inner diameter = 40–56 mm) bending experiments. The maximum absolute error of FP-RE was 0.11% compared with the ones obtained from FEA in Abaqus/explicit. In addition, the effects of the DAM characteristic parameters, viz., the support blocks amount, the effective magnification, and the effective support diameter, on the tube forming quality were discussed. The results indicated that: (a) An even number of support blocks could prevent the collapse of the outer convex tube wall and improve the quality of the inner concave tube wall. (b) When the DAM was used in the large inner diameter tubes bending, the larger non-contact area would cause an increase in the roundness section distortion. (c) For the tubes with the same diameter, a larger DAM diameter would lead to a smaller cross-section deformation degree, while the wall thinning was just the opposite. Finally, the result also proved that the DAM (the minimum effective diameter is 40 mm with six support blocks) could be used for tubes with an inner diameter of about 40–56 mm, and the forming quality was acceptable.
Patient engagement in Pharmacovigilance: determinants and evolution of reporting from 2011 to 2020 in France
Authors: Adopo D. , Daynes P. , Benkebil M. , Debs A. , Jonville-Berra AP , Polard E. , Micallef J. , Maison P. 
Published: August 2022

Abstract
Introduction: Because patients and patient organizations want to strengthen their role in the care pathway and drug evaluation and in order to improve pharmacovigilance activities, European competent authorities implemented regulations to allow direct reporting of adverse drug reactions related to medicinal products by patients in 2012. Objectives: Describe and study determinants and evolution of patient reporting activity in France to assess patient involvement in pharmacovigilance.Method: Using the French national pharmacovigilance database, univariate and multivariate analyses were performed to compare characteristics of patients and healthcare professionals (HCP) adverse drug reaction (ADR) report from 2011 to 2020. Then, we analyzed ADR report activities from patients according to regional demographics and economics characteristics.Results: We observed a significant and higher increase in ADR report over time from patient (r=0.89, p<0.001) compared to HCP reporting (r=0.27, p=0.002). Patient ADR report activities compared to HCP concerned more women (80% vs 55%, p<0.001), younger age classes (p<0.001) or reporting through web portal (83% vs 17%, p<0.001) and less serious events (26% vs 63%, p<0.001). In the principal component analysis, regional patient reporting activity was mainly related to socio-professional categories, age classes and densities of hospital beds and physicians. Conclusion: Our results confirm an increasing involvement of patients in ADR report activities. The determinants of patient reporting activities are not only related to drug and medical factors but also to social factors. Digital tools may also play a role in health democracy in pharmacovigilance.
Magnitude and associated factors of delirium among patients attending emergency department at Jimma medical center, Jimma, southwest Ethiopia, 2022
Authors: Sileshy Bethelhem , Tesfaye Yonas , Ababu Henok 
Published: August 2022

Abstract

Background:Delirium is a complex neuropsychiatric syndrome commonly encountered across all healthcare settings. It is associated with adverse outcomes including more prolonged hospitalization, institutionalization and increased mortality. In contrast to its frequent occurrence and negative consequences, delirium is missed by emergency physicians (EPs) in 57% to 83% of cases. Furthermore despite to its clinical importance, there is little documentation regarding delirium prevalence and physician detection rates within the emergency setting.Objectives:This study aimed to assess magnitude and associated factors of delirium among patients attending emergency department at Jimma medical center, Jimma, southwest Ethiopia, 2022.Methods:A hospital based cross-sectional study was conducted from August 1st up to September 30, 2022. 422 study participants were enrolled who were selected by systematic random sampling. The presence or absence of delirium was assessed by using Confusion Assessment Method (CAM) and Richmond Agitation Sedation Scale (RASS) was employed to assess distinct subtypes of delirium and level of arousal. The data was entered using Epi Data V3.1 and exported to Statistical Package for Social Scientists Version 20(SPSS V20). To find associated factors, bivariate and multivariable logistic regressions were used. Variables having a p-value of less than 0.05 were deemed statistically significant.Result:The prevalence of delirium was found to be 26.6%(n=107), current use of alcohol (AOR=3.6, 95 percent CI (2.5-8.1), visual impairment (AOR=2.34, 95 percent CI (1.89-3.68), frequent admission (AOR=3.47(1.24-7.34), bladder catheterization (AOR=1.4, 95 percent CI (1.21-2.89), 15.993), and benzodiazepine exposure (AOR=1.5, 95 percent CI (1.01-2.3) had significant association with delirium.Conclusion:This study shows the prevalence of delirium was high among patients in emergency ward. Current use of alcohol, visual impairment, frequent admission, bladder catheterization, and benzodiazepine exposure had significant association with delirium. Early recognition is important to correct identifiable cause and improve health outcome of patients.
Minimally invasive versus open esophagectomy after neoadjuvant therapy for esophageal cancer: a meta-analysis
Authors: Jin Zixian , Zhu Kanghao , Sun Jiajing , Zhang Jian , Zhang Bo 
Published: August 2022

Abstract
Objectives: Neoadjuvant therapy and minimally invasive esophagectomy (MIE) are widely used in the comprehensive treatment of esophageal cancer. This study aimed to investigate the advantages of MIE for esophageal cancer after neoadjuvant therapy.Methods: Published clinical studies were reviewed and survival data and safety data were extracted. We compared the long-term survival and safety of MIE versus open esophagectomy after neoadjuvant surgery in a series of meta-analyses.Results: 6 retrospective studies were included. Overall, MIE could significantly improve the overall survival of patients with esophageal cancer after neoadjuvant therapy compared with open esophagectomy [hazard ratio (HR)=0.86, 95% confidence interval (CI) (0.75, 0.98)]. Compared with open esophagectomy, MIE could significantly reduce intraoperative blood loss and operative time [mean difference (MD)=-40.28.78, 95%CI (-62.98, -17.58); MD=-28.78, 95%CI (-42.48, -15.07), respectively]. There was no significant difference in 30-day and 90-day mortality between MIE and open esophagectomy [odds ratio (OR)=0.42, 95%CI (0.09, 2.01); OR=0.80, 95%CI (0.25, 2.60), respectively]. MIE could reduce the incidence of anastomotic leakage, recurrent laryngeal nerve palsy and chylothorax [OR=0.70, 95%CI (0.37, 1.32); OR=1.43, 95%CI (0.33, 6.25); HR=1.79, 95%CI (0.67, 4.75), respectively], but the incidence of pneumonia was significantly reduced [HR=0.43, 95%CI (0.22, 0.82)]. In addition, the length of hospital stay and the incidence of total complications were significantly reduced after MIE [MD=-2.61, 95%CI (-3.10,-2.12); HR=0.66, 95%CI (0.45, 0.98), respectively].Conclusion: MIE after neoadjuvant therapy is effective and safe. Compared with open esophagectomy, MIE can improve the long-term survival and reduce the incidence of postoperative complications of esophageal cancer patients.
Comment on ‘Painlev´e Integrability and Multi-wave pattern for (2+1) dimensional long wave-Short wave resonance interaction system’
Authors: Ramaswamy Radha , Kumar C. Senthil 
Published: August 2022

Abstract
In the above paper [1], the authors make a tall claim about the integrability of a 2 component (2+1) dimensional Long wave Short wave Resonance Interaction (2C(2+1)LSRI) equation with mixed sign which was already claimed to be non integrable and hence known not to satisfy Painlev'e [2] property which the authors show to pass Painlev'e test. We have categorically shown how the system does not pass Painlev'e test and hence non-integrable reinforcing the claim made by Maruno et al [2] . The authors claim to derive the solutions of 2C(2+1)LSRI equation which ironically do not satisfy the equation. To top it all, the authors claim to have generated lumps and dromions which again defy their very own definition.
CD47 is correlated with immune infiltration and is a prognostic biomarker in colorectal cancer
Authors: Cai Chuanshu , Wang Peirong , Ke Chunlin , Shen Minmin , Dong Feng 
Published: August 2022

Abstract
Background: Colorectal cancer (CRC) is a common malignant neoplasm, and the cluster of differentiation 47 (CD47) is an innate immune checkpoint and promising diagnostic and therapeutic target. We comprehensively examined the potential prognostic value, clinicopathological characteristics, and immune infiltration associated with CD47 in CRC patients.Results: In total, 305 differentially expressed genes (DEGs) were identified. The receiver operating characteristic (ROC) curve analysis of CD47 suggested an area under the ROC curve of 0.819. Kaplan–Meier survival analysis indicated that CRC with high CD47 expression had a better prognosis in the progression-free interval (PFI; P = 0.011). Five drug targets (ABT-510, ALX148, TTI-621, CC-90002, and Hu5F9-G4) were identified for CD47. A positive correlation existed between CD47 expression and infiltrating levels of aDC, macrophages, T helper cells, Tcm, Th1 cells, Th2 cells, CD8 T cells, cytotoxic cells, neutrophils, T cells, and Tgd. In the neoplasm type, CD47 expression was higher in colon adenocarcinoma patients than in rectal adenocarcinoma patients (P = 0.029). In PFI events, CD47 expression was higher in live patients than in dead patients (P = 0.018). Male patients with high CD47 expression showed improved overall survival compared with female patients (P = 0.014). CD47 protein was highly expressed in colorectal tumor tissue and lowly expressed in normal tissues in the Human Protein Atlas(HPA). Methylation analysis of CD47 in CRC revealed that the first and second CpG islands were hypermethylated, whereas the third CpG island was hypomethylated. Genetic alterations in CRC included amplification and deletion of CD47 in colorectal cancer. I153M was found to be a mutational hotspot for CD47.Conclusions: CD47 is correlated with immune infiltration and is a prognostic biomarker in colorectal cancer.
Design and Analysis of Passive LC3 Star Component Buck Converter
Authors: Rahman Mohammad Dehan , Zohra Fatema Tuz , Solaiman Mohammad , Sarowar Golam 
Published: August 2022

Abstract
A comprehensive analysis on a novel LC3 star Buck converter is introduced in this paper. DC-DC, AC-DC and closed loop topology of the designed converter is examined. The analysis verifies the improvement done due to the implementation of the LC3 star arrangement. Efficiency of the proposed DC-DC converter has a maximum efficiency of 96.71%. For AC-DC, maximum efficiency is 97.47%. LC3 arrangement also improves the power and THD of the proposed AC-DC converter. To further improve the THD, a closed loop analysis is also done. Simulations are done by using PSIM software. A 10V prototype is made, which shows similar results with the theoretical analysis.
Alcohol use disorder and associated factors among residents in Fiche town, North Shewa, Ethiopia: Community based cross-sectional survey
Authors: zewde¹ Ofisa , Tulu Mikias , Desalegn Getachew Tesfaw 
Published: August 2022

Abstract
Background: Alcohol use disorder (AUD) is one of the most common psychiatric disorders. It accounts 4% of all death worldwide and the third leading risk factor for premature deaths and disabilities. The empirical evidence about AUD and associated factors is not available in the northern part of Ethiopia. Therefore, this study was assessed to the prevalence and associated factors of AUD among reside in Fich town in order to plan and give informed intervention in the communities. Methods: A community based cross-sectional survey was conducted from April to May 2019 at Fiche town north shewa, Ethiopia. Multi-stage random sampling was used to recruit 1619 participants. The standardized Alcohol Use Disorder Identification Test (AUDIT) was used to assess alcohol use disorder. Binary logistic regression analyses were used to identify factors associated with alcohol use disorder. The odds ratio (OR) with 95% confidence interval (CI) was computed to assess the strength of the association at p-value less than 0.05. Results: Overall prevalence of alcohol use disorder was found to be 15.7% with 95% CI (13.9-17.6), whereas hazardous drinkers (10.3%), harmful alcohol users (3.2%), and alcohol dependent (2.2%). In the multivariate logistic regression analysis; male sex (AOR=10.3, 95% CI: 6.63-16.00), age between 18-24 and 25-34 years (AOR=2.45, 95% CI: 1.10-5.44, and AOR=2.52, 95% CI: 1.23-5.16), respectively, peer pressure (AOR=4.51, 95% CI: 2.30-8.52), severe psychological distress (AOR=2.6, 95% CI: 1.24-5.43), and poor social support (AOR=3.1, 95% CI: 1.75-5.50) were factors significantly associated with alcohol use disorder. Conclusion: The findings of the present study indicated that the prevalence of alcohol used disorder among alcohol users was 15.7%. Being male, age between 18 to 34 years, peer pressure, severe psychological distress, and poor social support were significantly associated with AUD. Measures to increase the awareness of the community, their parents, and their social networks about AUD by the leading government as well as healthcare institutions are warranted.
COVID-19 Stock Market Experiences and Local Investors’ Investment Decisions in Lagos, Nigeria: a Pilot Study
Authors: Ekechukwu Iheanyi Valentine , Adejoh Ojima Samuel , Dinne Chinedu Ernest , Nwogu Joseph N 
Published: August 2022

Abstract
Economic activities were yet to pick up following the devastating effects of Covid-19 pandemic on stock market in Nigeria. Major cities were on complete lockdown for months leading to another phase of stock market crisis in 2021. This study explored Covid-19 stock market experiences and local investors’ investment decisions in Lagos, Nigeria. Organic theory of Emile Durkheim was adopted as framework, whereas exploratory design was employed. The study utilized purposive and snowballing sampling techniques, using purely qualitative research instruments with a sample of thirty-six (36) interviewees. Thirty in-depth interviews (IDI) and six key informants (KII), two each were purposively selected from staff of Nigerian Exchange Ltd (NGX), Securities and Exchange Commission (SEC) and Stockbrokers from Lagos State based on their in-depth professional knowledge about stock market operations. The qualitative data were content analyzed. 55.6% were men and 58.3% were married. The result of the study showed that local investors’ Covid-19 stock market experiences have greatly affected their present investment decisions. There is need for restoration of investors’ confidence in the Nigerian stock market.