bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytological observation and transcriptome analysis reveal dynamic changes of Rhizoctonia solani colonization on leaf sheath and different genes recruited between the resistant and susceptible genotypes in rice
Authors: Liu Sanglin , Wang Tianya , Meng Guoxian , Liu Jiahao , Lu Dibai , Liu Xiangdong , Zeng Yuxiang 
Published: November 2022

Sheath blight, caused by Rhizoctonia solani, is a big threat to the global rice production. To characterize the early development of R. solani on rice leaf and leaf sheath, two genotypes, GD66 (a resistant genotype) and Lemont (a susceptible genotype), were observed using four cytological techniques: the whole-mount eosin B-staining confocal laser scanning microscopy (WE-CLSM), stereoscopy, fluorescence microscopy, and plastic semi-thin sectioning after in vitro inoculation. WE-CLSM observation showed that, at 12 h post-inoculation (hpi), the amount of hyphae increased dramatically on leaf and sheath surface, the infection cushions occurred and maintained at a huge number from about 18 to 36 hpi, and then the infection cushions disappeared gradually from about 42 to 72 hpi. Interestingly, R. solani could not only colonize on the abaxial surfaces of leaf sheath but also invade the paraxial side of the leaf sheath, which shows a different behavior from that of leaf. RNA sequencing detected 6,234 differentially expressed genes (DEGs) for Lemont and 7,784 DEGs for GD66 at 24 hpi, and 2,523 DEGs for Lemont and 2,719 DEGs for GD66 at 48 hpi, suggesting that GD66 is recruiting more genes in fighting against the pathogen. Among DEGs, resistant genes, such as OsRLCK5, Xa21, and Pid2, displayed higher expression in the resistant genotype than the susceptible genotype at both 24 and 48 hpi, which were validated by quantitative reverse transcription–PCR. Our results indicated that the resistance phenotype of GD66 was the consequence of recruiting a series of resistance genes involved in different regulatory pathways. WE-CLSM is a powerful technique for uncovering the mechanism of R. solani invading rice and for detecting rice sheath blight–resistant germplasm.
A systematic review on lecturing in contemporary university teaching
Authors: Tronchoni Héctor , Izquierdo Conrad , Anguera M. Teresa 
Published: November 2022

IntroductionArticles published in scientific journals, concerning the present and future of the lecture format in university education in the twenty-first century are framed within organizational settings that drive teaching methodologies in line with educational policies. The following two research questions have arisen from articles in which debate the continuity of this teaching modality and propose improvements of a different nature: (1) Is there an interest in renovating the lecture format among the international research community whose remit is university teaching methods? and (2) What improvements to the lecture format do the reviewed articles suggest, within the framework of the communicative matrix of interactive learning?MethodWe have carried out a systematic review guided by the PRISMA approach, emphasizing the interest in methodological conceptual commitment, paying attention to documents published in journals with an impact factor. The search strategy was applied homogeneously in three databases: ERIC, PsycInfo, and Web of Science, following the systematic process of inclusion/exclusion.ResultsForty-five articles were selected with a range of 0–78 quotations, from different fields of knowledge and five continents; 12 articles are from journals with a JCR impact factor. The journal articles cover communicative (21), cognitive (13) and active-practical perspectives (11); the predominant governing aim of the analyzed improvements is connected with the attendees’ academic performance results (24); the reviewed studies belong mainly to the quantitative paradigm (42). The considerations derived from the results (45) cover formative, technical and/or critical aspects.Discussion and conclusionsWhilst positively valuing all these efforts promoted by the European Higher Education Area, we have also verified the lack of contributions in line with our concerns that embrace the need to develop an in-depth conceptualization, supported by a methodology that is sensitive to the complexity of the oral communication format between an expert actor and non-specialized actors who wish to connect and collaborate with the expert in the production of knowledge.
Rasch validation of the Arabic version of the beach center family quality of life scale (BCFQOL-AR)
Authors: Alnahdi Ghaleb Hamad 
Published: November 2022

AimThis study aimed to examine the dimensionality of the BCFQOL-AR using Rasch analysis.MethodThe sample consisted of 320 families having a member with intellectual or developmental disabilities. Rasch analysis was used to validate the dimensionality of the scale. The participants were from Riyadh, Saudi Arabia.ResultsThe BCFQOL-AR 25-item scale was multidimensional. Rasch analyses support the unidimensionality of the five subscales. There were no indicators of differential item function for any of the items, regardless of sex or age.ConclusionThe BCFQOL-AR is a multidimensional scale that measures families with members who are satisfied with their quality of life. Therefore, obtaining a total score at the subscale level is supported and showed that each of the five subscales of the BCFQOL can be used alone. This study partially supports the practices used with other versions of the scale, by providing the statistical base, where means were used at the subscale level in different countries.
Use of compulsory community treatment in mental healthcare: An integrative review of stakeholders’ opinions
Authors: de Waardt Dieuwertje Anna , van Melle Anne Laura , Widdershoven Guy Antoine Marie , Bramer Wichor Matthijs , van der Heijden Franciscus Martinus Machiel Adrianus , Rugkåsa Jorun , Mulder Cornelis Lambert 
Published: November 2022

BackgroundMultiple studies have examined the effects of compulsory community treatment (CCT), amongst them there were three randomized controlled trials (RCT). Overall, they do not find that CCT affects clinical outcomes or reduces the number or duration of hospital admissions more than voluntary care does. Despite these negative findings, in many countries CCT is still used. One of the reasons may be that stakeholders favor a mental health system including CCT.AimThis integrative review investigated the opinions of stakeholders (patients, significant others, mental health workers, and policy makers) about the use of CCT.MethodsWe performed an integrative review; to include all qualitative and quantitative manuscripts on the views of patients, significant others, clinicians and policy makers regarding the use of CCT, we searched MEDLINE, EMBASE, PsycINFO, CINAHL, Web of Science Core Collection, Cochrane CENTRAL Register of Controlled Trials (via Wiley), and Google Scholar.ResultsWe found 142 studies investigating the opinion of stakeholders (patients, significant others, and mental health workers) of which 55 were included. Of these 55 studies, 29 included opinions of patients, 14 included significant others, and 31 included mental health care workers. We found no studies that included policy makers. The majority in two of the three stakeholder groups (relatives and mental health workers) seemed to support a system that used CCT. Patients were more hesitant, but they generally preferred CCT over admission. All stakeholder groups expressed ambivalence. Their opinions did not differ clearly between those who did and did not have experience with CCT. Advantages mentioned most regarded accessibility of care and a way to remain in contact with patients, especially during times of crisis or deterioration. The most mentioned disadvantage by all stakeholder groups was that CCT restricted autonomy and was coercive. Other disadvantages mentioned were that CCT was stigmatizing and that it focused too much on medication.ConclusionStakeholders had mixed opinions regarding CCT. While a majority seemed to support the use of CCT, they also had concerns, especially regarding the restrictions CCT imposed on patients’ freedom and autonomy, stigmatization, and the focus on medication.
Differences in health behavior and nutrient intake status between diabetes-aware and unaware Korean adults based on the Korea national health and nutrition examination survey 2016–18 data: A cross-sectional study
Authors: Sharma Anshul , Lulu Chen , Song Kee-Ho , Lee Hae-Jeung 
Published: November 2022

BackgroundThe aim of this study was to investigate the nutritional intakes and treatment regimens of Korean patients with type 2 diabetes who were aware of their condition.MethodsParticipants (n = 16582) aged ≥ 19 years from the 2016–18 National Health and Nutrition Survey were divided into diabetes-aware and unaware groups and the variables were compared.ResultsAmong 1,906 (11.5%) diabetic adults, 1,433 (75.2%) were aware of their condition; 130 (9.1%) had nutrition education, and 1,340 (93.5%) were in the diabetes-aware treatment group. The diabetes-aware group had higher average age (P &lt; 0.0001) and lower average BMI (P = 0.0015) than the unaware group. Intake of total fat (P = 0.0034), saturated fatty acids (P = 0.0021), riboflavin (P = 0.0035) and niacin (P = 0.0228) was significantly higher in the unaware group than in the diabetes-aware group, after adjusting energy intake for age and sex. Current smoking (P = 0.0046) and heavy drinking (P &lt; 0.0001) rates were higher in the unaware group, whereas fiber intake (P = 0.0054) was lower in the unaware group. Higher levels of glycated hemoglobin were found in the group treated for diabetes (7.2%) than in the no-treatment (6.8%) group (P = 0.0048). Diabetes control was significantly better in the high income group.ConclusionsThere is a need to strengthen nutritional education to prevent diabetes and improve the health status of diabetic patients in Korea.
Cost-effectiveness analysis of sugemalimab vs. placebo, in combination with chemotherapy, for treatment of first-line metastatic NSCLC in China
Authors: Li Wei , Wan Li 
Published: November 2022

ObjectiveThe purpose of this study was to estimate the cost-effectiveness of sugemalimab plus chemotherapy (SC) vs. placebo plus chemotherapy (PC), as the first-line treatment for patients with non-small cell lung cancer (NSCLC) in China.Material and methodsA three-state Markov model with a cycle of 3 weeks was built to assess the incremental cost-effectiveness ratio (ICER) of SC vs. PC as first-line treatment for patients with NSCLC over a 10-year horizon from Chinese health care perspective. Time-dependency transition probability and safety data were derived from a multicenter, randomized, double-blind, phase 3 clinical trial performed in China (GEMSTONE-302). Primary model outcomes included the costs in US dollars and health outcomes in quality-adjusted life-years (QALYs) and the ICER under a willingness-to-pay (WTP) threshold of $37,663/QALYs. Deterministic, scenario and probabilistic sensitivity analysis were employed to investigate the robustness of model outcomes.ResultsIn base-case analysis, compared with PC, first-line SC for intention-to-treat (ITT) population gained an additional 0.57 QALYs with an incremental cost of $62,404.15, resulting in an ICER of $109,480.97/QALYs gained. When a patient assistance program (PAP) was available, the ICER decreased to $52,327.02/QALYs. In subgroup analysis, the ICER values were above the WTP threshold with or without PAP. Sensitivity analysis results suggested that the model outcomes were reliable.ConclusionFrom the perspective of Chinese healthcare system, the SC was not cost-effective in comparison to PC as first-line treatment for NSCLC, regardless of PD-L1 tumor expression level and pathological subtype.
Morphological and Molecular Characterization Using Genitalia and CoxI Barcode Sequence Analysis of Afrotropical Mosquitoes with Arbovirus Vector Potential
Authors: Montalvo-Sabino Eddyson , Abílio Ana Paula , Guarido Milehna Mara , Valadas Vera , Novo Maria Teresa , Kampango Ayubo , Sousa Carla Alexandra , Fafetine José , Venter Marietjie , Thompson Peter N. , Braack Leo , Cornel Anthony John , Parreira Ricardo , de Almeida António Paulo Gouveia 
Published: November 2022

Potential arboviral Afrotropical mosquito vectors are underrepresented in public databases of CoxI barcode sequences. Furthermore, available CoxI sequences for many species are often not associated with voucher specimens to match the corresponding fine morphological characterization of specimens. Hence, this study focused on the characterization of Culicine mosquitoes from South Africa, Mozambique, and Angola and their classification using a complementary approach including a morphological analysis of specimens’ genitalia and phylogenetic study based on the analysis of CoxI barcode sequences using maximum likelihood and Bayesian phylogenetic inference methods, alongside Median-Joining Network and PCOORD analyses. Overall, 800 mosquitoes (652 males and 148 females) from 67 species, were analyzed. Genitalia from 663 specimens allowed the identification of 55 species of 10 genera. A total of 247 CoxI partial gene sequences corresponding to 65 species were obtained, 11 of which (Aedes capensis, Ae. mucidus, Culex andersoni, Cx. telesilla, Cx. inconspicuosus, Eretmapodites subsimplicipes, Er. quinquevittatus, Ficalbia uniformis, Mimomyia hispida, Uranotaenia alboabdominalis, and Ur. mashonaensis) are, to the best of our knowledge, provided here for the first time. The presence of Cx. pipiens ecotypes molestus and pipiens and their hybrids, as well as Cx. infula, is newly reported in the Afrotropical region. The rates of correct sequence identification using BOLD and BLASTn (≥95% identity) were 64% and 53%, respectively. Phylogenetic analysis revealed that, except for subgenus Eumelanomyia of Culex, there was support for tribes Aedini, Culicini, Ficalbiini, and Mansoniini. A divergence >2% was observed in conspecific sequences, e.g., Aedeomyia africana, Ae. cumminsii, Ae. unilineatus, Ae. metallicus, Ae. furcifer, Ae. caballus, and Mansonia uniformis. Conversely, sequences from groups and species complexes, namely, Ae. simpsoni, Ae. mcintoshi, Cx. bitaeniorhynchus, Cx. simpsoni, and Cx. pipiens were insufficiently separated. A contribution has been made to the barcode library of Afrotropical mosquitoes with associated genitalia morphological identifications.
«ФЕНОМЕН» ЗЛОЧИННОСТІ УКРАЇНИ ТА ОСОБЛИВОСТІ ЇЇ ДЕТЕРМІНАЦІЇ В УМОВАХ РОСІЙСЬКОЇ АГРЕСІЇ
Authors: Колб О. 
Published: November 2022

У статті здійснено аналіз деяких кількісно-якісних показників вчинення кримінальних правопорушень у 2022 році, визначено особливості їх детермінації у воєнних умовах, а також розроблено науково обґрунтовані заходи, спрямовані на усунення існуючих у зв’язку з цим проблем.
IDEB e o SAEB
Authors: Santos Alessandra Cristina Pacheco , Nunes Stella Maris Lemos , Ferreira Adriana Assis 
Published: November 2022

O objetivo deste artigo é discutir e exemplificar como interpretar os resultados do IDEB e do SAEB de uma escola, considerando que tal análise pode contribuir para a melhoria do processo de ensino e aprendizagem. Especialmente com os resultados do IDEB, temos assistido, por parte da mídia e dos governos e secretarias, a divulgação de rankings entre as escolas, como se esse fosse o principal objetivo do sistema de avaliação, em detrimento da análise substantiva do significado daquele índice para aquela escola. Através de uma abordagem qualitativa, utilizamos a análise documental como instrumento de produção dos dados. Compreendemos que, a análise dos resultados dessas avaliações pode possibilitar interpretações pedagógicas, oportunizando a oferta de um ensino de melhor qualidade para todos os alunos, conforme preleciona a Constituição brasileira.
L'île Feydeau : problème de réaménagement d'un quartier ancien
Authors: Mesnard Annie 
Published: November 2022

Wenn man geographischen Rahmen, Bewohnerschaft und Gewerbe in der Feydeau - Insel erforscht - heute gehört die Insel, nachdem die Arme der Loire zugeschüttet wurden - lässt sich im Vergleich mit der Blütezeit im XVIII. Jahrhundert leicht feststellen, wie tief das Viertel heruntergekcmmen ist.
Durch die günstige Lage der Insel in der Stadtmitte und durch die Forderungen, welche die Ausdehnung der City stellt, ist jedoch eine neue Entwicklung im Stadtteil nachzuspüren. Damit er seine neuen Aufgaben erfüllen kann, muss er umgebaut werden : Der bauliche Rahmen muss wieder instand gestzt werden, während er den Forderungen der modernen Tätigkeit angepasst wird.
Les lignes assurant la traversée de la Manche à partir des ports normands
Authors: Hinschberger Félix 
Published: November 2022

Les lignes assurant le passage des voyageurs et de leurs véhicules à travers la Manche à partir des ports normands occupent une place intermédiaire, spatialement et par leur trafic, entre celles du Pas-de-Calais, par où transite l'essentiel du flux, et les lignes au départ des ports bretons, qui n'ont qu'une activité saisonnière.
Cherbourg, le mieux situé parmi les ports normands, s'inquiète du projet d'installation d'une nouvelle tête de ligne à Caen-Duistreham qui risque de lui détourner une partie de son trafic.
La France ligérienne
Authors: Chauvet Alain 
Published: November 2022

La France ligérienne fut dans le passé un carrefour où se rencontrèrent les courants de civilisation venus de l’Europe
continentale, du Monde Méditerranéen et de la Façade Atlantique. Elle demeure aujourd’hui un relais essentiel entre la France du Nord et celle du Midi d’une part, entre la France Océanique et la France Rhénohodanienne de l’autre.
Beaupréau et Chemillé : Deux petites villes du Maine-et-Loire
Authors: Meneux Anita 
Published: November 2022

Chemillé et Beaupréau deux petites villes de 6 000 habitants situées dans le Sud-Ouest du Maine et Loire, exercent un rayonnement très différent sur leur environnement. Alors que Chemillé entretient des relations très étroites et marquées avec sa campagne et constitue un pôle industriel et tertiaire au milieu d’un secteur agricole, Beaupréau, pour sa part, pôle tertiaire d’un secteur industriel, ne polarise pas aussi fortement son espace environnant.
Les deux communes, par contre, doivent aujourd’hui faire face à des problèmes de restructuration de leur espace urbain et les mesures adoptées rendent bien compte des attitudes des pouvoirs locaux face au problème urgent de la revitalisation du centre.
Caractéristiques et géographie du phénomène résidences secondaires sur l’Île d’Yeu
Authors: Schricke François 
Published: November 2022

Avec la fin du XlXe siècle, l’Ile d’Yeu devient un espace touristique attirant les résidents secondaires dont
beaucoup, au départ, ont des attaches familiales sur l’île.
Aujourd’hui, l’île abrite plus de 1 500 résidences de vacances. Souvent originaire de la Région Parisienne, le résident secondaire islais est assez jeune, exerce une profession libérale ou est cadre d’entreprise. Son implantation sur l’île résulte plus rarement qu’autrefois de ses attaches familiales. Mais de nouveaux réseaux, familial ou de voisinage, peuvent être observés sur l’espace islais.
Longtemps limitées aux bourgs ou aux plages proches de ceux-ci, les implantations concernent aujourd’hui l’ensemble de l’île, ce qui ne va pas sans poser des problèmes de protection de l’environnement.
Le centre-ville de Nantes : à la recherche d'un projet d'aménagement
Authors: Peyon Jean-Pierre 
Published: November 2022

Le centre-ville de Nantes reste marqué par l'héritage architectural et urbanistique du XVIIIe
siècle. Il a connu de profonds bouleversements dans les années Trente par le comblement des bras de la Loire et de l'Erdre. Des opérations de rénovation lourde ont été associées à la reconstruction d'après-guerre mais il faudra attendre la fin des années Soixante pour que la municipalité nantaise s'interroge sur l'avenir de ce riche patrimoine. La mise à l'étude, en 1972, d'un plan de sauvegarde, sa publication en 1980, marquent cette volonté mais les réalisations restent rares et le bilan est encore modeste, comparé à d'autres grandes villes françaises.
La diffusion de l'urbanisation dans les campagnes nantaises
Authors: Croix Nicole , Renard Jean 
Published: November 2022

L'article examine les rythmes, les formes et les conséquences sur l'espace, l'agriculture et les
sociétés locales de l'expansion de l'urbanisation dans les campagnes de la troisième couronne des communes péri-urbaines de l'agglomération nantaise. On observe une transformation accélérée des compositions et des structures de population, une évolution des équipements et une modification en profondeur des comportements et des pratiques. Il se crée ainsi un espace rural de plus en plus intégré au fait urbain.
La cartographie prospective de l’évolution du trait de côte : un instrument indispensable pour l’aménagement des espaces littoraux
Authors: Paskoff Roland 
Published: November 2022

The processes at work in coastal waters interact and shape the shore. In the last decades, important progress has been made in the analysis of nearshore dynamics and the resulting forms. However, if instrumentation, quantification, and modelling are very helpful for the understanding of short term and local effects, we must admit that our knowledge is still insufficient to use this approach for the prediction of large scale coastal behaviour with the required confidence.
Large scale coastal behaviour is defined as changes over a period of several tens of years and over a longshore distance corresponding to a coastal segment considered as an independant morpho-sedimentary unit
The interest in large scale coastal behaviour is increasing because it is of utmost importance for management to know which long term trend has to be expected in shoreline evolution. Such kind of approach implies analysis of maps, charts, and aerial photographs. The information has an empirical character which cannot only be used to define historical tendencies but can also be used directly to forecast future changes.
According to such a predictions model, setback lines may be established taking into account the expected life time of buildings. Doing so, the development of a retreating coast will not be soon followed by the well know "erosion problem" necessitating more and more elaborate, expensive, and too often unsightly defensive structures.
Versailles ou la leçon de géographie
Authors: Gras Jacques 
Published: November 2022

Évocation d’un cours donné autrefois par l’auteur à Nantes aux étudiants de la Licence de Géographie, et destiné à mettre en valeur les liens qui unissent Géographie Physique, Géographie Humaine et Histoire (dont celle de l’Art).
Si le milieu naturel commande toujours, il est l’objet, selon les époques, de lectures culturelles fort différentes, ce qui n’autorise pas le Géographe à s’en désintéresser, bien au contraire. Le cours portait sur Versailles (château et ville) et sur Cergy-Pontoise, deux “Villes Nouvelles” séparées par trois siècles mais conditionnées toutes deux par un même cadre géomorphologique qui est celui de l’Île de France.
Vive la géographie régionale ! Défense et illustration d’une discipline-mère recadrée par les méthodes modernes de l’analyse synthétique
Authors: Palierne Jean-Max 
Published: November 2022

Dans ce texte, l’auteur montre que, pour rester la science fondamentale qu’elle fut, la Géographie Régionale
doit recourir aujourd’hui aux méthodes modernes de l’Analyse Factorielle (assistée par ordinateur). En prenant pour exemple les États-Unis d’Amérique (et la France à un moindre titre), l’A. expose sa manière personnelle d’exploiter les traitements d’une mathématique efficace, féconde et non répulsive.