bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammatory response mediates cross-talk with immune function and reveals clinical features in acute myeloid leukemia
Authors: Zhong Fang-Min , Yao Fang-Yi , Liu Jing , Zhang Hai-Bin , Li Mei-Yong , Jiang Jun-Yao , Xu Yan-Mei , Yang Wei-Ming , Li Shu-Qi , Zhang Jing , Cheng Ying , Xu Shuai , Huang Bo , Wang Xiao-Zhong 
Published: April 2022

Abstract
Accumulated genetic mutations are an important cause for the development of acute myeloid leukemia (AML), but abnormal changes in the inflammatory microenvironment also have regulatory effects on AML. Exploring the relationship between inflammatory response and pathological features of AML has implications for clinical diagnosis, treatment and prognosis evaluation. We analyzed the expression variation landscape of inflammatory response-related genes (IRRGs) and calculated an inflammatory response score for each sample using the gene set variation analysis (GSVA) algorithm. The differences in clinical- and immune-related characteristics between high- and low-inflammatory response groups were further analyzed. We found that most IRRGs were highly expressed in AML samples, and patients with high inflammatory response had poor prognosis and were accompanied with highly activated chemokine-, cytokine- and adhesion molecule-related signaling pathways, higher infiltration ratios of monocytes, neutrophils and M2 macrophages, high activity of type I/II interferon (IFN) response, and higher expression of immune checkpoints. We also used the Genomics of Drug Sensitivity in Cancer (GDSC) database to predict the sensitivity of AML samples with different inflammatory responses to common drugs, and found that AML samples with low inflammatory response were more sensitive to cytarabine, doxorubicin and midostaurin. SubMap algorithm also demonstrated that high-inflammatory response patients are more suitable for anti-PD-1 immunotherapy. Finally, we constructed a prognostic risk score model to predict the overall survival (OS) of AML patients. Patients with higher risk score had significantly shorter OS, which was confirmed in two validation cohorts. The analysis of inflammatory response patterns can help us better understand the differences in tumor microenvironment (TME) of AML patients, and guide clinical medication and prognosis prediction.
Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage
Authors: Mirabito Colafella Katrina M. , van Dorst Daan C.H. , Neuman Rugina I. , Doorn Leni van , Neves Karla Bianca , Montezano Augusto C. , Garrelds Ingrid M. , van Veghel Richard , de Vries René , Uijl Estrellita , Clahsen-van Groningen Marian C. , Baelde Hans J. , van den Meiracker Anton H. , Touyz Rhian M. , Visser Willy , Danser A.H. Jan , Versmissen Jorie 
Published: April 2022

Abstract
Vascular endothelial growth factor antagonism with angiogenesis inhibitors in cancer patients induces a ‘preeclampsia-like’ syndrome including hypertension, proteinuria and elevated endothelin (ET)-1. Cyclo-oxygenase (COX) inhibition with aspirin is known to prevent the onset of preeclampsia in high-risk patients. In the present study, we hypothesised that treatment with aspirin would prevent the development of angiogenesis inhibitor-induced hypertension and kidney damage. Our aims were to compare the effects of low-dose (COX-1 inhibition) and high-dose (dual COX-1 and COX-2 inhibition) aspirin on blood pressure, vascular function, oxidative stress, ET-1 and prostanoid levels and kidney damage during angiogenesis-inhibitor therapy in rodents. To this end, Wistar Kyoto rats were treated with vehicle, angiogenesis inhibitor (sunitinib) alone or in combination with low- or high-dose aspirin for 8 days (n=5–7/group). Our results demonstrated that prostacyclin (PGI2) and ET-1 were increased during angiogenesis-inhibitor therapy, while thromboxane (TXA2) was unchanged. Both low- and high-dose aspirin blunted angiogenesis inhibitor-induced hypertension and vascular superoxide production to a similar extent, whereas only high-dose aspirin prevented albuminuria. While circulating TXA2 and prostaglandin F2α levels were reduced by both low- and high-dose aspirin, circulating and urinary levels PGI2 were only reduced by high-dose aspirin. Lastly, treatment with aspirin did not significantly affect ET-1 or vascular function. Collectively our findings suggest that prostanoids contribute to the development of angiogenesis inhibitor-induced hypertension and renal damage and that targeting the prostanoid pathway could be an effective strategy to mitigate the unwanted cardiovascular and renal toxicities associated with angiogenesis inhibitors.
Internet-Delivered Psychological Treatments for Tinnitus: A Brief Historical Review
Authors: Andersson Gerhard 
Published: April 2022

Objectives:
Internet-delivered psychological treatments were developed more than 20 years ago, and tinnitus was among the first target conditions. The aim of this review article is to describe the history of Internet treatments for tinnitus and to comment on the evidence base. Challenges for future research and implementations will be mentioned.

Method:
A narrative historical review was conducted.

Findings:
There are now several studies including controlled trials on Internet interventions based on cognitive behavior therapy (ICBT) for tinnitus. Effects in controlled trials are moderate to large with regard to tinnitus annoyance. While the treatment format now exists in four languages, there is a large treatment versus demand gap as very few clients with tinnitus receive ICBT. There is a lack of research on related conditions with the exception of hearing loss. However, there is substantial support for Internet interventions for comorbid conditions such as insomnia and depression but not specifically in association with tinnitus.

Conclusions:
ICBT is a promising treatment approach for tinnitus and will hopefully increase access to evidence-based treatment to reduce tinnitus distress. More research is needed for related conditions such as hyperacusis and larger trials on tinnitus.
Direct Speech-Language Intervention Effects on Augmentative and Alternative Communication System Use in Adults With Developmental Disabilities in a Naturalistic Environment
Authors: Hughes Deanna M. , Vento-Wilson Margaret , Boyd LouAnne E. 
Published: April 2022

Purpose:

Research involving the effects of augmentative and alternative communication (AAC) intervention in adults, especially in naturalistic settings, has been identified as a critical public health need. Despite rapid advances in high-tech AAC, many adults with developmental disabilities have experienced reduced access to assistive technology and AAC, which can function as a
de facto
environmental barrier to participation, for these individuals. As a means of decreasing barriers to participation, this study targeted skill increases in the operational, linguistic, social, and strategic use of AAC systems.

Method:
This study used a preexperimental, single-case AB design to identify skill level changes in the operational, linguistic, social, and strategic use of their AAC system from baseline to the completion of intervention. The four adult participants with developmental disabilities and limited use of natural speech as a primary modality of communication were identified through a collaborative relationship between a communication sciences and disorder university program and a state-run adult day program for individuals who had aged out of the K–12 school system. Each participant received direct intervention in the four areas described across 7 weeks.

Results:
Visual analysis and percent of nonoverlap of all pairs were used to identify changes in performance occurring between baseline and the conclusion of the intervention period. Results revealed increases across the specific skills, with individuals' variation across participants and target area. Out of 22 total goals targeted, strong effect sizes were observed for 10 goals and moderate effect sizes were observed for seven.

Conclusions:
Skill increases in the four areas of AAC system use can be achieved with direct intervention in adults with developmental disabilities and limited use of natural speech as a primary modality of communication. This approach also underscores the value of collaborations between university training programs, providers of adult services, and adult participants as a cost-effective strategy for service delivery.
We Need to Talk About Social Inequalities in Language Development
Authors: Di Sante Mélissa , Potvin Louise 
Published: April 2022

Purpose:
This article aims to raise speech-language pathologists' (SLPs') awareness about the extent of social inequalities in the language development of children, and their social determinants.

Method:
This article draws on empirical evidence and theoretical foundations from the field of public health to highlight the roots and distribution of social inequalities in the language development of children. The Total Environment Assessment Model for Early Child Development is presented as a means to understand the social determinants of early child development, and its relevance to the context of early language development is discussed. Informed by these theoretical notions, this article encourages SLPs to reflect on actions directed toward the social determinants of language. Drawing from health promotion approaches, a conceptualization of language interventions and intervention outcomes as “events in systems” is suggested.

Conclusion:
The public health–inspired approach to language interventions shared in this article invites institutions and SLPs to direct their gaze to the social determinants of language and broaden the scope of actions that are included in individual or group interventions aimed at supporting the language development of children.
Speech Recognition in Noise Performance Measured Remotely Versus In-Laboratory From Older and Younger Listeners
Authors: Shen Jing , Wu Jingwei 
Published: April 2022

Purpose:This study examined the performance difference between remote and in-laboratory test modalities with a speech recognition in noise task in older and younger adults.Method:Four groups of participants (younger remote, younger in-laboratory, older remote, and older in-laboratory) were tested on a speech recognition in noise protocol with 72 sentences.Results:While the younger remote group performed more poorly than the younger in-laboratory group, older participants' performance was comparable between the two modality groups, particularly in the easy to moderately difficult conditions. These results persisted after controlling for demographic variables (e.g., age, gender, and education).Conclusion:While these findings generally support the feasibility of remote data collection with older participants for research on speech perception, they also suggest that technological proficiency is an important factor that affects performance on remote testing in the aging population.
Minimally Detectable Change of Speech Intelligibility in Speakers With Multiple Sclerosis and Parkinson's Disease
Authors: Stipancic Kaila L. , Tjaden Kris 
Published: April 2022

Purpose:
This study sought to determine the minimally detectable change (MDC) of sentence intelligibility for speakers with multiple sclerosis (MS) and Parkinson's disease (PD).

Method:

Speakers included 78 participants consisting of 32 neurologically healthy control speakers, 30 speakers with MS, and 16 speakers with PD. All speakers were recorded reading 11 sentences comprising the Speech Intelligibility Test (SIT), which were subsequently transcribed by inexperienced listeners. Percent correct scores were calculated for each sentence. An average percent correct score was also calculated for each speaker. The MDC at the 95% confidence interval was calculated using the following formula: MDC
95
= 1.96 × √2 × standard error of measurement. Speakers were divided into operationally defined categories of severity, and MDCs were calculated for each category to permit comparison to MDCs reported for speakers with amyotrophic lateral sclerosis (ALS). Kruskal–Wallis tests were conducted to compare MDCs between groups and severity categories.

Results:

The average MDC
95
for control speakers was 5.53% (range = 3.21%–7.47%) and was statistically smaller than MDCs for speakers with MS (average = 10.08%, range = 5.30%–15.62%) and those for speakers with PD (average = 10.98%, range = 8.60%–13.98%). Statistical analyses further revealed significant differences between MDCs across severity categories.

Conclusions:

In agreement with previous work in ALS conducted under similar conditions (i.e., orthographic transcription of SIT sentences in a quiet listening environment), the MDC
95
of speech intelligibility ranged from 3% to 10% for speakers with MS and PD who have mildly impaired speech. These estimates are a step toward the development of a universal language with which to evaluate speech changes in a variety of patient populations.
Optimal placement of fixed series compensation and phase shifting transformer in the multi‐year generation and transmission expansion planning problem at the pool‐based market for maximizing social welfare and reducing the investment costs
Authors: Nourizadeh Heshmatollah , Mosallanejad Ali , SetayeshNazar Mehrdad 
Published: April 2022

AbstractMulti‐year generation and transmission expansion planning (MY‐G&TEP) is a critical issue in power systems. The present paper considers the optimal placement of Fixed Series Compensation (FSC) and Phase Shifting Transformer (PST) proposes a pool‐market‐based mathematical model (MY‐G&TEP) for maximizing social welfare (SW) and reducing investment costs of transmission lines and new power plants. Following the determination of optimal strategy, the present paper compares the usefulness of PSTs and FSCs in the MY‐G&TEP problem in three scenarios. Since MY‐G&TEP is a complex hybrid, mixed‐integer linear programming (MILP), and nonlinear optimization problem, the YALMIP toolbox and CPLEX solver have been applied to find the optimal solution, a globally optimized solution is obtained. For evaluation, the proposed model has been tested on the IEEE 24‐bus and IEEE 57‐bus systems, and the simulation results indicate that the installation of PST and FSC not only improves market conditions but also increases the flexibility of MY‐G&TEP, and adding these FACTS devices to the studied system leads to an increase in the network's performance and enhancement of objectives of the proposed model.
Enhancement of power quality issues for a hybrid AC/DC microgrid based on optimization methods
Authors: Khosravi Nima , Echalih Salwa , Baghbanzadeh Rasoul , Hekss Zineb , Hassani Rahman , Messaoudi Mustapha 
Published: April 2022

AbstractThe purpose of this paper is to study the harmonic behavior of hybrid microgrids (MGs). To achieve the desired goal, a modified active power filter (MAPF) and a power filter compensator kit (PFCK) modules have been used to improve the harmonics of the AC part of the system. The main challenge and feature of this research is the optimization of MAPF and PFCK controller gain coefficients hierarchical, using Harris hawk optimization (HHO), grasshopper optimization algorithm (GOA), artificial bee colony (ABC), and differential evolution (DE), respectively. Following, this technique was applied in the three control loops including, voltage and current harmonics, and system controller error to reduce the range of the mentioned harmonics to the permissible range. The method will be interesting considering that the PI and PID tuning is based on parallel feed‐forward. The programmed objective functions include the three components current THD, voltage THD and controller error hierarchically. From the point of view of the MGs hierarchical control, the method presented in this study will be implemented in the second level of hierarchical control. In order to improve the operation of the DC part of the grid, a boost converter module (BCM) has been introduced in the form of a new synchronization scheme. The output of the simulation shows the reduction of the harmonic amplitude of the system by the mentioned modules.
Novel approach for shipborne‐passive bistatic imaging with DVB‐T signals based on MIAA–RID technique
Authors: Wang Yong , Yang Jiaxing , Yeh Chunmao , Lu Xiaofei 
Published: April 2022

AbstractThe shipborne‐passive bistatic inverse synthetic aperture radar system with digital video broadcasting terrestrial (DVB‐T) signals is very important in the fields of radar imaging, but it suffers from the problems of grating lobes caused by the spectral gaps when multiple DVB‐T channels are applied, and the non‐stationary echo signal for the complex motions of the ship. In this paper, a new algorithm based on the Missing Data Iterative Adaptive Approach (MIAA) combined with the Range Instantaneous Doppler (RID) technique is proposed to address these problems. First, the authors establish the imaging geometry and signal model. Based on these models, the range resolution and Doppler frequency are analysed. Then, the bandwidth synthesis in the frequency domain for the DVB‐T signal is derived. Finally, the MIAA method is used to recover the spectral gaps of the range profile for multiple DVB‐T channels, and the azimuth compression is carried out by the RID method after the translational motion compensation. Simulation results show the effectiveness of the algorithm proposed in this paper.
Versorgung von Menschen mit Besonderheiten der Geschlechtsentwicklung
Authors: Groß Nele , Marshall Louise , Jürgensen Martina , Frielitz Fabian , Birnbaum Wiebke , Bacia Anna , Hiort Olaf 
Published: April 2022

ZUSAMMENFASSUNG
Hintergrund Die gesundheitsbezogene Lebensqualität von Menschen mit Besonderheiten der Geschlechtsentwicklung wird in der Literatur unterschiedlich dargestellt. Im Jahr 2006 wurden Rahmenpunkte der Versorgung festgelegt; zentral sind die Einbindung der Patient*innen in Entscheidungsprozesse, psychologische Begleitung sowie die multidisziplinäre Versorgung in Zentren. In Lübeck wurde ein Versorgungskonzept aufgebaut, das innerhalb dieses Rahmens eine hohe gesundheitsbezogene Lebensqualität von Patient*innen ermöglichen soll. Dieses Konzept wird im vorliegenden Beitrag evaluiert.
Methodik Von 2017 bis 2020 wurden 68 Patient*innen und Elternteile mittels eines standardisierten Fragebogens befragt (CHC-SUN, Child Health Care – Satisfaction, Utilization and Needs, in einer an die Sprechstunde adaptierten Form). Zusätzlich wurden mit sieben Studienteilnehmer*innen Telefoninterviews geführt.
Ergebnisse Die Befragten gaben überwiegend an, großes Vertrauen in das interdisziplinäre Team aufgebaut zu haben. Durch die Erklärungen des Teams konnten sie die geschlechtliche Besonderheit verstehen und medizinische Entscheidungen sicher treffen. Die Anwesenheit einer Psychologin war entscheidend, um Ängste und Zukunftssorgen zu besprechen. Die Befragten fanden überwiegend zu einem positiven Umgang mit der Diagnose.
Diskussion Das Versorgungskonzept kann als Modell dienen, um eine hohe Behandlungszufriedenheit zu erreichen. Die Diagnose anzunehmen, stellt für Patient*innen und Familien einen herausfordernden Prozess dar, den das Sprechstundenteam unterstützend begleiten kann. Die Studie war jedoch durch ein kleines Kollektiv limitiert.
Clinical Application of the Satisfaction with Amplification in Daily Life Scale in Private Practice I: Statistical, Content, and Factorial Validity
Authors: Hosford-Dunn Holly , Halpern Jerry 
Published: April 2022

AbstractStatistical, content, and factorial validity of the Satisfaction with Amplification in Daily Life (SADL) scale was assessed. SADL subscales closely correspond to four satisfaction domains. Subjective benefit is a key component of satisfaction, but other nonauditory factors contribute to wearer satisfaction, notably telephone use and appearance. Results confirm the SADL's psychometric properties and verify its use to validate hearing aid fitting satisfaction in private practice settings for a general patient population at 1–year postfitting. Interim SADL norms may be refined as more SADL data are obtained for different patient populations, hearing aid types, and fitting environments.
Abbreviations: PP-SADL = private practice SADL group, SADL = Satisfaction with Amplification in Daily Life
Predicting Directional Hearing Aid Benefit for Individual Listeners
Authors: Ricketts Todd , Mueller H. Gustav 
Published: April 2022

AbstractThe fitting of directional microphone hearing aids is becoming increasingly more routine, and this fitting option has proven to be a successful method to improve speech intelligibility in many noisy listening environments. Data suggest, however, that some hearing-impaired listeners receive significantly more directional benefit than others. It is of interest, therefore, to determine if directional benefit is predictable from identifiable audiologic factors. In this report, we examined whether the slope of audiometric configuration, amount of high-frequency hearing loss, and/or the aided omnidirectional performance for a speech-in-noise intelligibility task could be used to predict the magnitude of directional hearing aid benefit. Overall results obtained from three separate investigations revealed no significant correlation between the slope of audiometric configuration or amount of high-frequency hearing loss and the benefit obtained from directional microphone hearing instruments. Although there was a significant, negative relationship between aided omnidirectional performance and the directional benefit obtained in one study, there was considerable variability among individual participants, and nearly all of the listeners with the best omnidirectional hearing aid performance still received significant additional benefit from directional amplification. These results suggest that audiologists should consider the use of directional amplification for patients regardless of audiogram slope, high-frequency hearing loss, or omnidirectional speech intelligibility score.
Abbreviations: BTE = behind the ear, Dl = Directivity Index, DSP = digital signal processing, HINT = Hearing in Noise Test, ITE = in the ear, NAL-NL1 = National Acoustic Laboratories-Nonlinear 1, SNR = signal-to-noise ratio
Internet memes we live by (and die by)
Authors: Xie Chaoqun 
Published: April 2022

Abstract
In the internet age, memes are at once products and driving forces of social practices. A meme contains a memetic message and a meme output, and boasts, if guided by a pragmatic way of thinking, several features, including, but not limited to, salience, frequency, adaptability, argumentativity, sociality, embeddedness, embodiedness, locality, relativity, emotionality and dynamicity. The current global COVID-19 pandemic serves as a fitting and timely touchstone to testify how human beings are surrounded by numerous good and evil memes in the online world, and how internet memes, as can be seen from the illustration of two specific memes, namely, the ‘stay home, stay safe’ meme and the ‘wear a mask’ meme, are impacting human life-worlds, online and offline, with their transformative power, be it constructive or destructive. Moreover, researching how memes plays a decisive part in internet-mediated interaction provides a lens of insight through which ‘deep states’ of human nature of both self and others can be uncovered and through which what Nietzsche (2002, 2017) called “a revaluation of values” is possible.