bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the Effects of Facility-Specific Guideline and Nudge-Based Antimicrobial Stewardship at Pediatric Primary Emergency Medical Centers
Authors: Otake Shogo , Kusama Yoshiki , Tsuzuki Shinya , Myojin Shota , Kimura Makoto , Kamiyoshi Naohiro , Takumi Toru , Ishida Akihito , Kasai Masashi 
Published: February 2022

Abstract
Purpose: Antimicrobial prescription rates tend to be high in outpatient settings. Primary emergency medical centers (PECs) in Japan encounter difficulties in implementing antimicrobial stewardship programs (ASPs). While a nudge-based ASP significantly reduces inappropriate prescription of oral third-generation cephalosporins (3GCs), publishing monthly newsletters requires considerable effort. Therefore, developing more preferable ASP models in PECs is essential. Methods: We conducted a multi-center, quasi-experimental study. The Himeji Primary Emergency Medical Center for Nights and Holidays (Site A) introduced the facility-specific guideline referring to national guidelines. The Kobe Children's Primary Emergency Medical Center (Site B) provided the results of the monitoring for antibiotics prescription as a monthly newsletter. The Hanshin-Kita Children’s First-Aid Center (Site C) did not perform the specific ASP. Prescription rates for 3GCs were categorized into pre- and post-intervention and compared using Poisson regression analysis. The difference-in-difference method was used to assess the effect of these interventions. Results: The numbers of patients pre- and post- intervention were 177,126 and 91,251, respectively. The 3GCs prescription rate at Site A, Site B, and Site C decreased from 6.7%, 4.2%, and 6.1% in 2016 to 2.3%, 1.0%, and 2.0% in 2019, respectively. Site B had a greater reduction than Site A and Site C (odds ratio [OR] 0.81 [95% confidence interval (CI) 0.70–0.93]; P<0.001, OR 0.76, [95%CI 0.66–0.87]; P=0.004). There was no significant difference between Site A and Site C (OR 0.94 [95%CI 0.83–1.06]; P=0.33). Conclusions: Facility-specific guideline was less effective than nudge-based ASP for decreasing oral third-generation cephalosporins prescription in PECs.
Expression of Annexin A5 in maternal blood and placenta in pregnancies with preeclampsia
Authors: Teng Meng , Yu Jing , Pan Yidan , Yang Qiyuan , Zhang Binbin , Wu Suihan , Weng Zhanping 
Published: February 2022

Abstract
Background

The placental anticoagulant protein Annexin A5 is highly expressed on the apical surfaces of syncytiotrophoblasts and plays an important role in maintaining blood fluidity in the placental circulation. We investigated the expression of Annexin A5 in maternal blood and placentas from pregnancies complicated by preeclampsia compared with uncomplicated pregnancies.

Materials and Methods

Placental tissue and maternal blood were collected from pregnancies complicated by preeclampsia. They were classified into two groups: early-onset group (n = 10), late-onset group (n = 10) .10 women without perinatal complications who accepted elective term cesarean section were chosen as the control group. Western blot and immunohistochemistry were used to detect the expression and localization of Annexin A5 in the placenta. Annexin A5 mRNA expression was quantified by Real-Time PCR. Annexin A5 and coagulation factor Xa in maternal blood was measured by an enzyme-linked immunosorbent assay. Prothrombin time, activated partial thromboplastin time, Thrombin time, fibrinogen were detected in each groups.

Results

(1) The expression of Annexin A5 in maternal blood were: 5.54±0.29 in early-onset group; 5.10±0.28 in late-onset group; 4.5±0.19 in control group. They were significantly higher in preeclampsia groups than in control group (P = 0.013). However, there was no significant difference among preeclampsia groups (P > 0.05). The mean ±SD coagulation factor Xa expression in the early-onset and late-onset group were 1229.23±45.33 and 1366.96±56.30 versus 1372.95±45.44 in the control group, which has not statistically significant(P=0.072). (2) The protein expression of Annexin A5 in placenta was not statistically significant between the early-onset, late-onset, and control groups (mean ± SD): 0.01 ± 0.02, 0.95±0.03vs.0.99 ± 0.02, p = 0.071.(3) The Annexin A5 mRNA levels in placenta were: 0.79±0.23 in early-onset group; 1.18±0.53 in late-onset group; respectively. All were significantly lower than that in control group (6.19±1.68, P =0.024), and no significant difference was found among preeclampsia groups (P > 0.05). (4) Prothrombin time, activated partial thromboplastin time, Thrombin time, fibrinogen levels were: (11.9 ± 0.23), (33.38± 0.85) s, (16.88 ± 0.45) g/L and 3.85 ± 0.23 in early-onset group; (11.65 ± 0.12), (33.15 ± 0.36) s, (16.13 ± 0.19) g/L and 4.91 ± 0.14 in late-onset group; (12.01 ± 0.09), (32.08 ± 0.41) s, (16.34 ± 0.24) g/L and 4.32 ± 0.20 in control group. The first three were no significant difference among preeclampsia groups and control group (P > 0.05), fibrinogen was statistically significant among all groups (P < 0.05).

Conclusion

These results suggest that Annexin A5 plays an important role in the pathogenesis and progression of preeclampsia by affecting coagulation.
Prenatal and postpartum maternal mental health and neonatal motor outcomes during the COVID-19 pandemic
Authors: Papadopoulos Alissa , Nichols Emily S. , Mohsenzadeh Yalda , Giroux Isabelle , Mottola Michelle F. , Lieshout Ryan J. , Duerden Emma G. 
Published: February 2022

Abstract
Background
Rates of prenatal and postpartum stress and depression in pregnant individuals have increased during the COVID-19 pandemic. Perinatal maternal mental health has been linked to worse motor development in offspring, with motor deficits appearing in infancy and early childhood. We aimed to evaluate the relationship between prenatal and postpartum stress and depression and motor outcome in infants born during the COVID-19 pandemic.
Methods
One hundred and seventeen participants completed an online prospective survey study at two timepoints: during pregnancy and within 2 months postpartum. Depression was self-reported using the Edinburgh Perinatal/Postpartum Depression Scale (EPDS), and stress via the Perceived Stress Scale (PSS). Mothers reported total infant motor ability (fine and gross) using the interRAI 0–3 Developmental Domains questionnaire.
Results
Prenatal (B=-0.035, 95%CI=-0.062 to -0.007, p = .014) and postpartum maternal depression outcome (B=-0.037, 95%CI= -0.066 to -0.008, p = 0.012) were significant negative predictors of total infant motor ability (fine and gross). Neither pregnancy nor postpartum perceived stress predicted infant motor function. A cluster analysis revealed that preterm and low birth weight infants belonging to mothers who reported elevated depressive symptoms during pregnancy and in the postpartum period had the poorest motor outcome.
Conclusions
Prenatal and postpartum depression, but not stress, predicted infant motor ability during the first 2 months of life. Preterm and low-birth weight infants of mothers who report elevated depressive symptoms are the most at-risk of experiencing poor motor outcome.
HIF-1α upregulation exerts the antagonistic effect against angiogenesis inhibition in manganese deficiency-induced tibial dyschondroplasia of broiler chicks
Authors: lu lu , Jin Cong , Dong Peng-Fei , Wang Lin , Wang Zhen-Yong 
Published: February 2022

Abstract
Manganese (Mn) is an essential microelement for broiler breeding and its deficiency causes tibial dyschondroplasia (TD). Tibial growth plate (TGP) development and metaphyseal vascularization are crucial for tibia growth in fast-growing broiler chickens, but their roles in Mn deficiency-induced TD in chicks remains unclear. This study was designed to clarify this issue. A total of 36 one-day-old broilers were divided into the control group and Mn-deficiency (Mn-D) group, which were fed with a standard diet (60 mg Mn/kg) and Mn deficiency diet (22 mg Mn/kg) for 42 days, respectively. TGP and proximal tibial metaphysis were collected to perform the related assays. First, Mn deficiency decreased the tibia length and TGP thickness in TD model. Mn deficiency reduced the number of blood vessels in proximal tibial metaphysis by histological analysis. Also, Mn deficiency decreased the mRNA and protein expression levels of vascular endothelial growth factor (VEGF) and macrophage migration inhibitory factor (MIF) in TGP. Moreover, up-regulation of hypoxia-inducible factor-1 alpha (HIF-1α) at both mRNA and protein levels was found in TGP of Mn-D group, suggesting the antagonistic role of HIF-1α against angiogenesis inhibition. Additionally, Mn deficiency enhanced the autophagy related 5 (ATG5) and microtubule associated protein 1 light chain 3 beta (LC3-II) expression levels, but decreased the SQSTM1 (p62) expression levels in TGP, suggesting autophagy activation in this process. Collectively, these data indicate that HIF-1α up-regulation and concurrent autophagy activation exert the protective effect against Mn deficiency-induced angiogenesis inhibition, which may provide a useful guidance to prevent TD in broilers.
Sexually Transmitted Infections (STIs) increased the risk of precancerous cervical lesions among women in Ethiopia: unmatched case-control study
Authors: Teklehaimanot Dereje Abebe , Derseh Behailu Tariku , Mekuria Abinet Dagnew , Dadi Abel Fekadu 
Published: February 2022

Abstract
Objective: This study aimed to identify the determinants of cervical pre-cancerous lesions among women who attend cervical cancer screening in public health facilities.Design: An institution-based, unmatched case-control study was conducted among 216 women (54 cases and 162 controls) from January 2020 to April 2020. Settings: Selected public health facilities in North Shoa Zone, Amhara, Ethiopia.Participants: Women aged 30 - 49 who were attending cervical cancer screening at health institutions were included in this study. Outcome measures: Cases were women who attended cervical cancer screening and tested positive for Visual Inspection with Acetic Acid (VIA), whereas controls were women who tested negative for VIA. Results: Women who used oral contraceptives for more than 5 years were approximately 5 times more likely to develop pre-cancerous lesions (Adjusted Odds Ratio (AOR) = 4.75; 95% CI: 1.48, 15.30), and early age at first sexual intercourse (<15 years) increased the odds of developing pre-cancerous lesion by 4 fold (AOR = 3.77; 95% CI: 1.46, 9.69). Women having HIV seropositive results and had a previous history of sexually transmitted infections (STIs) had a 3.4 (AOR = 3.45; 95% CI: 1.29, 9.25) and 2.5(AOR = 2.58; 95% CI: 1.10, 6.09) times more odds of developing cervical pre-cancerous lesions than their counterparts. Conclusions: the use of oral contraceptives for more than five years, early initiation of sex, past and current STI increased the odds of women’s developing pre-cancerous cervical lesions. Awareness creation and the National cervical cancer screening program should prioritize women with identified exposures.
Implementation of Back At work After Surgery (BAAS): a feasibility study of an intergrated pathway for improved return to work after knee arthroplasty
Authors: Strijbos Daniel Otto , Sluis Geert van der , Boymans Tim A.E.J. , de Groot Stephan , Klomp Simon , Kooijman Carolien M. , Reneman Michiel F. , Kuijer Paul P.F.M. 
Published: February 2022

Abstract
Purpose
Optimizing return to work after knee arthroplasty becomes more important because of the growing incidence of KA among workers and poor return to work outcomes. The purpose of this study is to investigate the feasibility of Back At work After Surgery (BAAS): an integrated clinical pathway for return to work after knee arthroplasty.
Method
Working patients who received unicompartmental knee arthroplasty (UKA) or total knee arthroplasty (TKA) between January 2021 and November 2021, younger than 65 years and motivated to return to work were eligible to participate. Feasibility was investigated on five domains: reach, dose delivered, dose received, fidelity and patients’ attitudes. These outcomes were obtained by a patient-reported questionnaire and an interview with the case manager occupation and case manager medical.
Results
Of the eligible 29 patients, eleven were willing to participate (response rate 29%; due to travel distance to and from the hospital). The reach from professionals was 100%. The dose delivered between 91–100%, except information given about return to work from the orthopedic surgeon which was 18%. The dose received was 100%. For fidelity, case managersreported nine shortcomings for which five solutions were mentioned. In terms of patients’ attitude, all patients were satisfied and one patient mentioned an improvement.
Conclusions
In terms of reach, participation was low: only 29%. In terms of dose delivered, dose received, fidelity and patient attitudes of the BAAS clinical pathway seems feasible. The next step will be to assess the effectiveness of the BAAS clinical pathway for return to work.
Spatial targeting and prediction of factors responsible for optimum Covid-19 based social distancing – the case of Upper west region, Ghana
Authors: Asori Moses , Musah Ali , Peprah Prince 
Published: February 2022

Abstract
Covid-19 has become a significant global public health concern due to its faster rate of mortality and morbidities. Various precautionary measures such as social distancing have been outlined across the globe to reduce its transmission. However, the practicality of implementing the social distancing is a function of multiple factors including; urban morphology, population density and availability of essential socioeconomic services. Using Getis-Ord G* and Spatial-Cluster outlier analysis, we targeted the hotspot centres where effective social distancing will be difficult to achieve within Upper West Region in order to optimize intervention and resource allocation. We also examined factors determining effective Social Distancing using Geographically Weighted Regression (GWR). Ease of achieving social distancing index (ESDI) was acquired from WorldPop Group Research centre at Southampton University, Freshwater availability from Socioeconomic Data and Applications Center (SEDAC) and Average household size from DHIMS-2. Our spatial statistical analysis indicates that ESDI is significantly spatially auto-correlated; with hotspots occurring generally at the urban core. Using both the global (OLS) and local (GWR) regression models, we found that, relationships between ESDI and built-up area, built-up proportion, population density and freshwater availability were statistically significant. We suggest that areas where it is difficult to achieve social distancing due to built-up design or population density, constant surveillance should be adopted for timely detection.
REQUISITOS E INDICADORES DE AVALIAÇÃO PARA CENTRAIS DE ABASTECIMENTO FARMACÊUTICO
Authors: Batista Padilha Santos Mayara , Rodrigues de Castilho Selma , Teixeira Pontes André 
Published: February 2022

Objetivo: Identificar os requisitos e indicadores de avaliação das atividades desenvolvidas em Centrais de Abastecimento Farmacêutico (CAF) de gestão pública.
Método: Trata-se de uma scoping review realizada a partir de consulta aos bancos de dados Scopus, PubMed, Google Acadêmico, SCIELO, websites da ANVISA e do CFF.
Fundamentação teórica: As CAF centralizadas são responsáveis pelo armazenamento e distribuição de medicamentos diretamente às unidades de dispensação dos municípios. A avaliação das CAF constitui uma ferramenta de apoio à gestão no aprimoramento dos processos e redução de custos.
Resultados: Foram selecionados 57 documentos da literatura científica e cinzenta. A maior parte dos estudos demonstrou problemas com o armazenamento e distribuição de medicamentos, assim como gerenciamento de recursos humanos nas CAF. A legislação mais recente prevê mudanças no setor de logística farmacêutica. Foi elaborado um modelo com requisitos e indicadores para CAF, que considera legislação atualizada.
Conclusões: Os resultados apresentados fomentam a criação de um instrumento de avaliação para detectar oportunidades de melhoria nos estabelecimentos e direcionar a tomada de decisão.
Sufism and Pandemic: Lesson Learned from Sufi Teachings and its Prominent Figures
Authors: Setiawan Mohamad Nur Kholis 
Published: February 2022

Religious perspective is an important aspect to be used in dealing with the COVID-19 global pandemic and the Islamic one is not an exception. It is Sufism that concerns more on the spiritual dimension of Islam that might be taken into consideration. Based on several books on Sufi scholars and teachings, such as al-Isfahani’s Ḥilyat al-Auliyā’ wa-ṭabaqāt al-Aṣfiyā, al-Attar’s Tadhkirat al-Auliyā, al-Sakandari’s al-Ḥikam, and others, this article proposes Sufi teachings as inevitable tools in facing the pandemic. Using content analysis, intertextuality, and historical approaches, this paper concludes how Sufism with its basic teachings such as ‘uzlah, ṣumtu, qanā’ah, shukr, et cetera, will be the suitable elements for Muslims to face and overcome the pandemic. Several prominent Sufi scholars will also be used to strengthen the argument.
Role of the Sūfis During the Pandemic in a Society: COVID-19 in Nigeria as a Case Study
Authors: Solagberu Abdur-Razzaq Mustapha Balogun 
Published: February 2022

COVID – 19 is the code given to an infectious disease called Coronavirus. It was on 31st December 2019 that World Health Organization (WHO) was kept informed of its discovery. It was speculated that the disease was first discovered in the Republic of China. It then spread from there to other countries of the world, including Nigeria. Multiple efforts were put in place in an attempt to halt its spread in the country, i.e., Nigeria. One of such was to lockdown the country. The pandemic and lockdown had various effects on society and its people in multiple ways. As a result, people found themselves in a state of frustration and anxiety, looking forward to a remedy and solution. This paper, therefore, determines to examine the role of the Sūfis during this kind of situation with the hope of bringing the role of the Sūfis into the limelight and to put it on record the Sūfi resilience and effort on the spiritual being of the Sūfi adherents at a particular time. The method adopted in this research is based on the interpretative approach in line with the disciplines of Islamic Studies, especially Sufism and history. The main result of the study reveals that the pandemic has both positive and negative effects on people generally. Finally, through its teachings, Sufism provides resilience to the public, especially its adherents.
PENDIDIKAN AGAMA DALAM KULTUR SEKOLAH DEMOKRATIS: POTENSI MEMBUMIKAN DERADIKALISASI AGAMA DI SEKOLAH
Authors: Jannet Herly 
Published: February 2022

This study aimed in general to determine and describe the religious education in a democratic school culture is one of potential strategies in disseminating religious de-radicalization in schools. Applying qualitative naturalistic approach with case study, this study focused the location in Christian High School Urimessing Ambon. The object of this research was the all democratic phenomena found in the process of teaching and learning of Christian education. The results of this study can be described as follows: religious education in a democratic school culture has the potential to disseminate de-radicalization because the learning process optimized the attitude of critical thinking on freedom, independence, and accountability that were assumed to build the belief, attitude and norm of student to: (1) deepen and believe their own religious teachings; (2) commit to transform their religious teacgings in their daily life, both individually and socially; and (3) be­come the real who got off from violence and anarchy in realizing their objectives.***Penelitian ini bertujuan untuk menemukan dan mendeskripsikan Pendidikan Agama dalam kultur sekolah demokratis sebagai salah satu strategi membumikan deradikalisasi agama di sekolah. Metode penelitian yang digunakan adalah kuali­tatif naturalistik dengan strategi studi kasus dan mengambil tempat penelitian di SMA Kristen Urimessing Ambon. Objek penelitian ini adalah keseluruhan gejala demokratis dalam proses belajar mengajar Pendidikan Agama Kristen. Hasil pe­nelitian dapat dideskripsikan sebagai berikut, Pendidikan Agama dalam kultur sekolah demokratis berpotensi membumikan deradikalisasi, karena dalam pro­ses belajar mengajar mengoptimalkan sikap kebebasan berpikir kritis, ke­mandiri­an, dan akuntabilitas sehingga dapat membentuk keyakinan, sikap dan nor­ma pe­serta didik untuk: (1) mendalami dan meyakini ajaran agamanya sendiri; (2) ber­komitmen mentransformasikan ajar­an agamanya secara baik dalam ke­hidupan pribadi maupun sosial ber­masyarakat; dan (3) memberi teladan secara konkret tidak terjebak menggunakan kekerasan dan anarkisme dalam mewujudkan keinginan.
Zaburzenia odżywiania się – częsty problem współczesnej młodzieży
Authors: Kochman Dorota , Jaszczak Marzena 
Published: February 2022

Wstęp. Zaburzenia odżywiania się stanowią bardzo ważny problem zdrowotny XXI wieku zarówno w Polsce jak i na świecie. Dotyczy on przede wszystkim dziewcząt w wieku dojrzewania oraz młodych kobiet, jednakże coraz częściej także chłopcy cierpią na zaburzenia odżywiania. Grupa ta, pod względem tworzenia własnych postaw żywieniowych, charakteryzuje się wysoką podatnością za wpływ społeczno-kulturowy i rodzinny.
Cel. Celem pracy jest analiza wybranych zaburzeń odżywiania w światle literatury przedmiotu.
Materiał i metody. W pracy dokonano przeglądu literatury poświęconej zaburzeniom odżywiania.
Przegląd. Zaburzenia odżywiania definiowane są jako szkodliwy dla jednostki sposób odżywiania przejawiający się niewłaściwymi zachowaniami w aspekcie ilości, sposobu, częstości jedzenia posiłków, a także jakości potraw oraz towarzyszących emocji. Na występowanie zaburzeń odżywiania się ma wpływ szereg czynników. Nigdy nie należy kończyć leczenia na etapie pomocy w objawach somatycznych.
Wnioski. Niewątpliwie bardzo ważna jest rola pielęgniarki w opiece nad osobą z zaburzeniami odżywiania i profilaktyce tych stanów.
Information and Communications Technology Challenges as Instructional Media in Gambia Vocational High Schools
Authors: Suso Manding , Djatmiko Istanto Wahyu , Romadhon Muhammad Imron , Jobarteh Bubacarr 
Published: February 2022

This study explores Information and Communications Technology (ICT) challenges for instructional media at five different Vocational High Schools in the Gambia. Three aspects of data were measured: computer knowledge, internet facilities, and instructional media. The method used in this study involved descriptive research. Data collection methods included closed-ended questioners. The population consists of 164 students from grade 10 class, 50 students from Saamasang, 25 students from Bottrop, 25 from John Pickering, 32 students from St. peter’s, and 32 students from Mingdaw. SPSS 22 software was used to manage the gathered data. The data analysis technique was a descriptive and correlation analysis statistic. Correlation analysis serves to find out whether each school has the same challenges of ICT. Findings revealed that computer knowledge, internet facilities, and instructional media pose the highest challenges. This study concluded that the teachers have an excellent chance to improve applied ICT for enhancing quality learning in the Gambia.