bluuebunny/crossref_metadata_2025_split huggingface dataset:
Echinococcus granulosus sensu stricto and antigen B may decrease inflammatory bowel disease through regulation of M1/2 polarization
Authors: Bao Jianling , Qi Wenjing , Sun Chang , Tian Mengxiao , Jiao Hongjie , Guo Gang , Guo Baoping , Ren Yuan , Zheng Huajun , Wang Yuezhu , Yan Mei , Zhang Zhaoxia , McManus Donald P. , Li Jun , Zhang Wenbao 
Published: October 2022

Abstract
Background
Inflammatory bowel disease (IBD) is a chronic idiopathic disease characterized by inflammation-related epithelial barrier damage in the intestinal tract. Helminth infection reduces autoimmune disease symptoms through regulation of inflammatory responses based on hygiene theory. However, the underlying mechanisms remain unclear.

Methods
BALB/c mice were infected with microcysts of E. granulosus sensu stricto and drank water containing 3.5% dextran sodium sulfate (DSS) at the 100th day post-infection. After 7 days of drinking DSS, the mouse body weight change and disease activity index (DAI) were recorded every day, and colon length and histological score were evaluated after sacrifice. After injection with antigen B (AgB), inducible nitric oxide synthase (iNOS) and Fizz1 expression and F4/80+CD11c+ M1 and F4/80+CD206+ M2 in the peritoneal cells and colon tissues were analysed by qPCR and flow cytometry, respectively. Gut microbiota were profiled by 16S rRNA sequencing of the mouse faecal samples. For in vitro assay, RAW264.7 macrophages were cultured in medium containing AgB before induction by lipopolysaccharide (LPS). Then, NO in the supernatant was measured, and the expression of cytokine genes associated with macrophages were determined by qRT-PCR.

Results
Echinococcus granulosus s.s. infection and AgB significantly reduced the symptoms and histological scores of IBD induced by DSS (P < 0.05). Flow cytometry showed that AgB inoculation increased F4/80+ and CD206+ in peritoneal cells. The results of qPCR showed that AgB significantly decreased iNOS and increased Fizz1 expression in the colon of mice inoculated by DSS (P < 0.05). Furthermore, AgB injection led to significant changes in the profiles of five genera (Paraprevotella, Odoribacter, Clostridium cluster XlVa, Oscillibacter, and Flavonifractor) in faecal samples. In vitro analysis showed that AgB reduced NO levels (P < 0.01), with a significant decrease in iNOS expression (P < 0.05) in RAW264.7 cells induced by LPS.

Conclusions
Echinococcus granulosus infection and AgB may improve IBD conditions by inducing an M2-predominant cellular (F4/80+ CD206+) profile and decreasing type 1 macrophages (F4/80+CD11c+) in the intestinal lamina propria. In addition, AgB intervention induced changes in the microbiota condition of the gastrointestinal duct and reversed NO expression. Thus, AgB may be a drug candidate for IBD treatment.

Graphical Abstract
Tim-3 downregulation by Toxoplasma gondii infection contributes to decidual dendritic cell dysfunction
Authors: Xie Hongbing , Li Zhidan , Zheng Guangmei , Yang Chunyan , Liu Xianbing , Xu Xiaoyan , Ren Yushan , Wang Chao , Hu Xuemei 
Published: October 2022

Abstract
Background
Women in early pregnancy infected by Toxoplasma gondii may have severe adverse pregnancy outcomes, such as spontaneous abortion and fetal malformation. The inhibitory molecule T cell immunoglobulin and mucin domain 3 (Tim-3) is highly expressed on decidual dendritic cells (dDCs) and plays an important role in maintaining immune tolerance. However, whether T. gondii infection can cause dDC dysfunction by influencing the expression of Tim-3 and further participate in adverse pregnancy outcomes is still unclear.

Methods
An abnormal pregnancy model in Tim-3-deficient mice and primary human dDCs treated with Tim-3 neutralizing antibodies were used to examine the effect of Tim-3 expression on dDC dysfunction after T. gondii infection.

Results
Following T. gondii infection, the expression of Tim-3 on dDCs was downregulated, those of the pro-inflammatory functional molecules CD80, CD86, MHC-II, tumor necrosis factor-α (TNF-α), and interleukin-12 (IL-12) were increased, while those of the tolerant molecules indoleamine 2,3-dioxygenase (IDO) and interleukin-10 (IL-10) were significantly reduced. Tim-3 downregulation by T. gondii infection was closely associated with an increase in proinflammatory molecules and a decrease in tolerant molecules, which further resulted in dDC dysfunction. Moreover, the changes in Tim-3 induced by T. gondii infection further reduced the secretion of the cytokine IL-10 via the SRC-signal transducer and activator of transcription 3 (STAT3) pathway, which ultimately contributed to abnormal pregnancy outcomes.

Conclusions
Toxoplasma gondii infection can significantly downregulate the expression of Tim-3 and cause the aberrant expression of functional molecules in dDCs. This leads to dDC dysfunction, which can ultimately contribute to abnormal pregnancy outcomes. Further, the expression of the anti-inflammatory molecule IL-10 was significantly decreased by Tim-3 downregulation, which was mediated by the SRC-STAT3 signaling pathway in dDCs after T. gondii infection.
Efficacy and safety of guselkumab and adalimumab for pustulotic arthro-osteitis and their impact on peripheral blood immunophenotypes
Authors: Ueno Masanobu , Miyagawa Ippei , Miyazaki Yusuke , Hanami Kentaro , Fukuyo Shunsuke , Kubo Satoshi , Nakayamada Shingo , Tanaka Yoshiya 
Published: October 2022

Abstract
Objectives
We compared the treatment effectiveness between guselkumab and adalimumab in patients with pustulotic arthro-osteitis (PAO). In addition, we performed peripheral blood immunophenotyping to elucidate the immunological background and analyzed the impact of therapeutic drugs to verify the validity of immunological phenotypes as therapeutic targets.

Methods
Patients were treated with guselkumab 100 mg (guselkumab group; n = 12) and adalimumab 40 mg (adalimumab group; n = 13). Arthritis disease activity, skin lesion activity, and patient-reported outcomes (PROs) were evaluated and compared between the two groups. The retention rate and adverse events were evaluated. Comprehensive phenotyping of peripheral immune cells was performed in both groups, and phenotypes were compared before and after treatment.

Results
At 6 months, both groups showed significant improvement in arthritis disease activity and PROs. In the guselkumab group, skin symptoms significantly improved. The 6-month continuation rates were 91.7% (11/12) and 69.2% (9/13) in the guselkumab and adalimumab groups, respectively. Adverse events occurred in 2/12 and 5/13 patients in the guselkumab (16.7%) and adalimumab (38.5%) groups, respectively. Peripheral blood immunophenotyping showed that the proportion of activated T helper (Th) 1 cells was significantly lower in patients with PAO than in healthy controls and that the proportion of activated Th17 cells was significantly higher in patients with PAO, which significantly decreased after treatment with guselkumab.

Conclusion
Although guselkumab and adalimumab have comparable efficacy for PAO, their impact on immunophenotypes varies.
Network meta-analysis on the efficacy and safety of finerenone versus SGLT2 inhibitors on reducing new-onset of atrial fibrillation in patients with type 2 diabetes mellitus and chronic kidney disease
Authors: Zhang Yaofu , Wang Junheng , Jiang Li , Wang Tongxin , Li Zhuang , Fu Xiaozhe , Huang Weijun , Xiao Yonghua , Wang Shidong , Zhao Jinxi 
Published: October 2022

Abstract
Objective
To evaluate the efficacy and safety of finerenone and sodium-glucose cotransporter-2 inhibitors (SGLT2i) on reducing new-onset of atrial fibrillation (AF) in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD).

Method
We searched the PubMed, Cochrane Library, Web of Science, Medline and Embase covering January 1, 2000 to April 30, 2022. Randomized control trials comparing finerenone or SGLT2i with placebo in patients with T2DM and CKD were selected. Results were reported as risk ratio (RR) with corresponding 95% confidence interval (CI).

Results
A total of 10 studies (35,841 patients) were included. Finerenone (RR 0.79, 95% CI 0.62–0.99) was associated with a decreased risk of AF compared with placebo, while SGLT2i were not. SGLT2i were associated with a decreased risk of hospitalization for heart failure (RR 0.78, 95% CI 0.63–0.98) compared with finerenone. They were comparable in AF(RR 0.84, 95% CI 0.48,1.46), major adverse cardiovascular events(MACE) (RR 0.93, 95% CI 0.81,1.06) and nonfatal stroke(RR 0.78, 95% CI 0.58,1.05). They both showed no significant risk of adverse events compared with placebo.

Conclusion
There was no significant difference in the reduction of new-onset of atrial fibrillation between Finerenone and SGLT2i based on the indirect comparisons of currently available clinical studies. The large-sampled head-to-head trials was needed for the more precise conclusion.
Obstructive sleep apnea risk and its associated factors among type 2 diabetes mellitus patients at wolkite university specialized hospital, Wolkite, Southern Ethiopia, 2021. A comparative cross-sectional study
Authors: Wondie Alemayehu , Taderegew Mitku Mammo , Girma Betemariam , Getawey Atsede , Tsega Daniel , Terefe Tamene Fetene , Mitiku Shimelis , Berhanu Hiwot 
Published: October 2022

AbstractBackgroundObstructive sleep apnea is a syndrome characterized by recurrent partial, or complete upper airway collapse during sleep. Although obstructive sleep apnea is common in type 2 diabetes mellitus, the majority of patients remain undiagnosed because of the prohibitive cost of the test and paucity of the sleep clinic, especially in developing nations. The study aimed to assess high-risk obstructive sleep apnea and its associated factors among type 2 diabetes mellitus patients at Wolkite University Specialized Hospital.MethodsA Hospital-based comparative cross-sectional study was employed from October 15 to December 5, 2021, among 204 participants. Data collection was done by semi-structured interviewer-administered questionnaires. Data was entered into the Epi data version 4.6 and exported to SPSS version 25.0 for analysis. Independent t-test and chi-square test were used to compare continuous and categorical variables accordingly. Binary and multiple logistic regression analysis was used to assess factors associated with high-risk obstructive sleep apnea. Statistical significance was set at P-value < 0.05.ResultsA total of 204 participants with an equal proportion of the two groups were included with a 100% response rate. About 56.9% of the participants were males. The mean age of type 2 diabetes mellitus patients was 57.1 (± 12.0) years and the non-diabetic group was 55.3 (± 10.9) years. The prevalence of high-risk obstructive sleep apnea among type 2 diabetes mellitus was 42.2%, and that of non-diabetics was 13.7% (p < 0.001). Age (AOR: 1.13; 95%CI: 1.04, 1.22), neck grasp (AOR: 6.48; 95%CI: 1.56, 26.96), waist circumference (AOR: 4.44; 95%CI: 1.12, 17.61) and the presence of diabetes-related complications (AOR: 4.18; 95%CI: 1.13, 15.43) were independently associated with high-risk obstructive sleep apnea among type 2 diabetes mellitus patients.ConclusionThe prevalence of high-risk obstructive sleep apnea among type 2 diabetes mellitus was higher with a significant difference from their comparison group. Age, neck grasp, waist circumference, and diabetes-related complications were significantly associated with high-risk obstructive sleep apnea among type 2 diabetes mellitus patients. Therefore, type 2 diabetes mellitus patients should be screened for obstructive sleep apnea in the early course of their follow-up to take preventive measures and early treatments.
Feature stability and setup minimization for EEG-EMG-enabled monitoring systems
Authors: Cisotto Giulia , Capuzzo Martina , Guglielmi Anna Valeria , Zanella Andrea 
Published: October 2022

AbstractDelivering health care at home emerged as a key advancement to reduce healthcare costs and infection risks, as during the SARS-Cov2 pandemic. In particular, in motor training applications, wearable and portable devices can be employed for movement recognition and monitoring of the associated brain signals. This is one of the contexts where it is essential to minimize the monitoring setup and the amount of data to collect, process, and share. In this paper, we address this challenge for a monitoring system that includes high-dimensional EEG and EMG data for the classification of a specific type of hand movement. We fuse EEG and EMG into the magnitude squared coherence (MSC) signal, from which we extracted features using different algorithms (one from the authors) to solve binary classification problems. Finally, we propose amapping-and-aggregationstrategy to increase the interpretability of the machine learning results. The proposed approach provides very low mis-classification errors ($$<0.1$$<0.1), with very few and stable MSC features ($$<10\%$$<10%of the initial set of available features). Furthermore, we identified a common pattern across algorithms and classification problems, i.e., the activation of thecentro-parietalbrain areas andarm’s muscles in 8-80 Hz frequency band, in line with previous literature. Thus, this study represents a step forward to the minimization of a reliable EEG-EMG setup to enable gesture recognition.
An efficient quality of services based wireless sensor network for anomaly detection using soft computing approaches
Authors: Mittal Mohit , Kobielnik Martyna , Gupta Swadha , Cheng Xiaochun , Wozniak Marcin 
Published: October 2022

AbstractWireless sensor network (WSN) is widely acceptable communication network where human-intervention is less. Another prominent factors are cheap in cost and covers huge area of field for communication. WSN as name suggests sensor nodes are present which communicate to the neighboring node to form a network. These nodes are communicate via radio signals and equipped with battery which is one of most challenge in these networks. The battery consumption is depend on weather where sensors are deployed, routing protocols etc. To reduce the battery at routing level various quality of services (QoS) parameters are available to measure the performance of the network. To overcome this problem, many routing protocol has been proposed. In this paper, we considered two energy efficient protocols i.e. LEACH and Sub-cluster LEACH protocols. For provision of better performance of network Levenberg-Marquardt neural network (LMNN) and Moth-Flame optimisation both are implemented one by one. QoS parameters considered to measure the performance are energy efficiency, end-to-end delay, Throughput and Packet delivery ratio (PDR). After implementation, simulation results show that Sub-cluster LEACH with MFO is outperforms among other algorithms.Along with this, second part of paper considered to anomaly detection based on machine learning algorithms such as SVM, KNN and LR. NSLKDD dataset is considered and than proposed the anomaly detection method.Simulation results shows that proposed method with SVM provide better results among others.
Market outlet choices for African Indigenous Vegetables (AIVs): a socio-economic analysis of farmers in Zambia
Authors: Arumugam Surendran , Govindasamy Ramu , Simon James E. , Van Wyk Emil , Ozkan Burhan 
Published: October 2022

AbstractAgricultural research institutes in Sub-Sahara Africa have focused on establishing farmer groups that facilitate the commercial production and marketing of African Indigenous Vegetables (AIVs) to address food and nutritional security. With the freedom of selecting the choices of market outlets, we explored the factors such as farmers’ characteristics, farm attributes, selling preferences, social relations, and other primary reasons that influence farmers' decision to choose a particular outlet to sell AIVs. A purposive random survey was conducted among the AIV farmers to understand the preferred market outlets for AIVs in Zambia. The results of the multinomial logit model indicate that male respondents are more likely to choose intermediary options to sell AIVs, particularly brokers and wholesalers. The rainfed farmers and those who receive primary income from farming activities are less likely to choose retailers and wholesalers to market their AIVs. Similarly, those who expect instant payment for their produce indicate that they are less likely to prefer retailers and brokers. Farmers who belong to the farmer's group exhibited a positive coefficient, meaning that they are more likely to choose intermediary options to sell their AIVs compared with the farmer-to-consumer direct sales option. However, good price, a positive momentum of AIVs price in the past, and processing activities were found to be insignificant determinants for market outlet choices when compared with farmer-to-consumer direct outlet option. Our findings could help to better cognize AIVs marketing channels and develop the intervention for new farmers to make an informed decision as to how best to market their AIVs.
Safe and effective treatment of venous Thromboembolism associated with Cancer: focus on direct Oral Anticoagulants in Asian patients
Authors: Lee Lai Heng , Danchaivijitr Pongwut , Uaprasert Noppacharn , Gill Harinder , Sacdalan Dennis Lee , Ho Gwo Fuang , Parakh Rajiv , Pai Paresh , Lee Jen-Kuang , Rey Nannette , Cohen Alexander T. 
Published: October 2022

AbstractCancer-associated thrombosis (CAT) poses a significant disease burden and the incidence in Asian populations is increasing. Anticoagulation is the cornerstone of treatment, but can be challenging due to the high bleeding risk in some cancers and the high risk of recurrent venous thromboembolism (VTE) in patients with malignancies. Direct oral anticoagulants (DOACs) are well established as first-choice treatments for VTE in non-cancer patients, offering a more convenient and less invasive treatment option than low-molecular-weight heparin (LMWH). Asian patients have exhibited comparable efficacy and safety outcomes with other races in trials of DOACs for VTE in the general population. Although no specific data are available in Asian patients with CAT, results from randomized controlled trials of apixaban, edoxaban, or rivaroxaban versus the LMWH, dalteparin, indicate that DOACs are a reasonable alternative to LMWH for anticoagulation in Asian patients with CAT. This is further supported by analyses of real-world data in Asian populations demonstrating the efficacy and safety of DOACs in Asian patients with CAT. Apixaban, edoxaban, or rivaroxaban are recommended in the most recently updated international guidelines as first-line therapy for CAT in patients without gastrointestinal or genitourinary cancers and at low risk of bleeding. An increased risk of major gastrointestinal bleeding was evident with edoxaban or rivaroxaban, but not apixaban, versus dalteparin in the clinical trials, suggesting that apixaban could be a safe alternative to LMWH in patients with gastrointestinal malignancies. Determining the optimal anticoagulant therapy for patients with CAT requires careful consideration of bleeding risk, tumor type, renal function, drug–drug interactions, financial costs, and patients’ needs and preferences.
Empowering engineering with data, machine learning and artificial intelligence: a short introductive review
Authors: Chinesta Francisco , Cueto Elias 
Published: October 2022

AbstractSimulation-based engineering has been a major protagonist of the technology of the last century. However, models based on well established physics fail sometimes to describe the observed reality. They often exhibit noticeable differences between physics-based model predictions and measurements. This difference is due to several reasons: practical (uncertainty and variability of the parameters involved in the models) and epistemic (the models themselves are in many cases a crude approximation of a rich reality). On the other side, approaching the reality from experimental data represents a valuable approach because of its generality. However, this approach embraces many difficulties: model and experimental variability; the need of a large number of measurements to accurately represent rich solutions (extremely nonlinear or fluctuating), the associate cost and technical difficulties to perform them; and finally, the difficulty to explain and certify, both constituting key aspects in most engineering applications. This work overviews some of the most remarkable progress in the field in recent years.
Role of time perspectives and self-control on well-being and ill-being during the COVID-19 pandemic: A multiple mediation model
Authors: Zong Min , Dong Dan , Yang Zhizun , Feng Yi , Qiao Zhihong 
Published: October 2022

AbstractBackgroundA growing body of evidence indicates that the outbreak of COVID-19 has had a significant influence on individuals’ cognition, emotion, and psychological health. This study aims to explore the effect of the association between time perspectives and self-control on the well-being and ill-being among college students in China during the COVID-19 pandemic.MethodsWe conducted an online survey involving 1,924 participants in mainland China during the outbreak of COVID-19. A series of self-rating questionnaires measuring the perceived impact of COVID-19, time perspectives, self-control, as well as the statuses of well-being and ill-being were administered. Multiple indirect effects of time perspectives and self-control on well-being and ill-being were analysed through structural equation modelling.ResultsThe present-hedonistic time perspective (an orientation on immediate impulses of pleasure) meditated the effects of perceived impacts on both well-being and ill-being, and the future time perspective (considering the outcomes of actions and decisions) mediated the effects on well-being. Moreover, the mediating effects were further mediated by self-control. Specifically, the impact of the future time perspective on ill-being was fully mediated by self-control (β = 0.01, p < 0.01).ConclusionBased on the results, it is evident that the present-hedonistic time perspective, the future time perspective, and self-control are related to higher levels of well-being and lower levels of ill-being, thereby providing further insight into the theoretical framework of time perspectives during the COVID-19 pandemic. Additionally, our findings provide practical implications for psychological interventions during the on-going COVID-19 pandemic, focusing on the effects of time perspectives and self-control on the well-being and ill-being of different individuals.