bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the Components Within Apollo 16 Ferroan Anorthosite Suite Cataclastic Anorthosite Sample 60025: Implications for the Lunar Magma Ocean Model
Authors: Torcivia M. A. , Neal C. R. 
Published: January 2022

AbstractThe ferroan anorthosite suite (FAS) represents the only direct sampling of the lunar magma ocean (LMO) and potentially contains information on the earliest history of the Moon. Apollo 16 FAS sample 60025 is extremely important for understanding early lunar evolution, but unraveling this information is complicated. For example, 60025 has two distinct Sm‐Nd crystallization ages that in themselves encapsulate the complicated history of this sample, along with the cataclastic and heterogeneous textures exhibited. Here, we present new in situ major and trace element plagioclase and pyroxene data gathered from five thin sections of 60025 that highlight such complexities. Trace element data are used to derive equilibrium liquids and while many of the minerals analyzed here are consistent with derivation from the LMO, there are also a significant number of plagioclase and pyroxene crystals that crystallized from magmas inconsistent with current models of LMO evolution. Integration of Sm‐Nd isotopic data with the elemental data reported here indicate a nonchondritic LMO is possible and we confirm that 60025 is a polymict lunar breccia containing differently sourced material.
Light People: Elizabeth Rogan
Authors: Wang Hui , Yu Cun 
Published: January 2022

EditorialThroughout history, there have been many outstanding women whose achievements continue to impress and amaze us today. For example, in the field of science, Madame Marie Curie was the first woman Nobel Prize winner and the only person to be awarded a Nobel Prize in two scientific fields. From China, Tu Youyou is a Nobel laureate who discovered artemisinin and dihydroartemisinin, used to treat malaria, a breakthrough in twentieth-century tropical medicine, saving millions of lives around the globe. Businesswomen such as Angela Ahrendts, a former fashion executive who helped revitalize Apple, Inc., and Sheryl Sandberg, Chief Operating Officer of Meta Platforms (formerly Facebook), are recognized as two of the world’s most influential business leaders.Now, more than ever, women are at the forefront of developments in optics and photonics research and business. One of those leaders is Elizabeth Rogan, CEO of Optica (formerly the Optical Society and the Optical Society of America.) As the executive in charge of an organization devoted to promoting the generation, application, archiving, and dissemination of knowledge in optics and photonics worldwide, Ms. Rogan has successfully expanded the depth and breadth of Optica’s technical and global reach. Her education and expertise are in industry, finance, and strategy. She utilizes these skills in partnership with a large and technically diverse group of Ph.D. volunteers and staff specialists. Combining the efforts of these many talented people with a unity of purpose has proven to be a highly effective approach for Rogan and the association she has led for nearly two decades.Ms. Rogan is a strong advocate for women. For instance, the association’s “Faces of Optica” campaign features a wide range of accomplished women in research and applications. And she was an enthusiastic participant in the “Rose in Science,” which celebrates the extraordinary accomplishments of women scientists.Light Special Correspondents interviewed Elizabeth Rogan about Optica’s legacy, culture, and personal experiences as its CEO in this issue. She also discussed the reasons behind the recent rebranding of the organization and the bonds of friendship the Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, and Optica have built over the years.Please join us for an in-depth look at why this century-plus-year-old organization has a fresh new vision for the future.
Mining imaging and clinical data with machine learning approaches for the diagnosis and early detection of Parkinson’s disease
Authors: Zhang Jing 
Published: January 2022

AbstractParkinson’s disease (PD) is a common, progressive, and currently incurable neurodegenerative movement disorder. The diagnosis of PD is challenging, especially in the differential diagnosis of parkinsonism and in early PD detection. Due to the advantages of machine learning such as learning complex data patterns and making inferences for individuals, machine-learning techniques have been increasingly applied to the diagnosis of PD, and have shown some promising results. Machine-learning-based imaging applications have made it possible to help differentiate parkinsonism and detect PD at early stages automatically in a number of neuroimaging studies. Comparative studies have shown that machine-learning-based SPECT image analysis applications in PD have outperformed conventional semi-quantitative analysis in detecting PD-associated dopaminergic degeneration, performed comparably well as experts’ visual inspection, and helped improve PD diagnostic accuracy of radiologists. Using combined multi-modal (imaging and clinical) data in these applications may further enhance PD diagnosis and early detection. To integrate machine-learning-based diagnostic applications into clinical systems, further validation and optimization of these applications are needed to make them accurate and reliable. It is anticipated that machine-learning techniques will further help improve differential diagnosis of parkinsonism and early detection of PD, which may reduce the error rate of PD diagnosis and help detect PD at pre-motor stage to make it possible for early treatments (e.g., neuroprotective treatment) to slow down PD progression, prevent severe motor symptoms from emerging, and relieve patients from suffering.
ROSIE, a database of reptilian offspring sex ratios and sex-determining mechanisms, beginning with Testudines
Authors: Krueger Caleb J. , Janzen Fredric J. 
Published: January 2022

AbstractIn contrast to genotypic sex determination (GSD), temperature-dependent sex determination (TSD) in amniotic vertebrates eludes intuitive connections to Fisherian sex-ratio theory. Attempts to draw such connections have driven over 50 years of research on the evolution of sex-determining mechanisms (SDM), perhaps most prominently among species in the order Testudines. Despite regular advancements in our understanding of this topic, no efforts have been published compiling the entirety of data on the relationships between incubation temperature and offspring sex in any taxonomic group. Here, we present the Reptilian Offspring Sex and Incubation Environment (ROSIE) database, a comprehensive set of over 7,000 individual measurements of offspring sex ratios in the order Testudines as well as SDM classifications for 149 species. As the name suggests, we plan to expand the taxonomic coverage of ROSIE to include all non-avian reptiles and will regularly release updates to maintain its comprehensive nature. This resource will enable crucial future research probing the ecology and evolution of SDM, including the presumed sensitivity of TSD to rapid environmental change.
A cell-based phenotypic library selection and screening approach for the de novo discovery of novel functional chimeric antigen receptors
Authors: Fierle Julie K. , Abram-Saliba Johan , Atsaves Vasileios , Brioschi Matteo , de Tiani Mariastella , Reichenbach Patrick , Irving Melita , Coukos George , Dunn Steven M. 
Published: January 2022

AbstractAnti-tumor therapies that seek to exploit and redirect the cytotoxic killing and effector potential of autologous or syngeneic T cells have shown extraordinary promise and efficacy in certain clinical settings. Such cells, when engineered to express synthetic chimeric antigen receptors (CARs) acquire novel targeting and activation properties which are governed and orchestrated by, typically, antibody fragments specific for a tumor antigen of interest. However, it is becoming increasingly apparent that not all antibodies are equal in this regard, with a growing appreciation that ‘optimal’ CAR performance requires a consideration of multiple structural and contextual parameters. Thus, antibodies raised by classical approaches and intended for other applications often perform poorly or not at all when repurposed as CARs. With this in mind, we have explored the potential of an in vitro phenotypic CAR library discovery approach that tightly associates antibody-driven bridging of tumor and effector T cells with an informative and functionally relevant CAR activation reporter signal. Critically, we demonstrate the utility of this enrichment methodology for ‘real world’ de novo discovery by isolating several novel anti-mesothelin CAR-active scFv candidates.
Wood ash biocatalyst as a novel green catalyst and its application for the synthesis of benzochromene derivatives
Authors: Rostamian Rezvaneh , Khalilzadeh Mohammad A. , Zareyee Daryoush 
Published: January 2022

AbstractWood ash is a naturally alkaline derived substance containing organic and inorganic constituents. This study investigates the catalytic activity of wood ash as a heterogeneous catalyst for the synthesis of benzochromene derivatives. Several wood ash catalysts, comprising calcium- and potassium-rich carbonates, were prepared from different natural resources under various combustion temperatures. The prepared catalysts were characterized by Fourier transform infrared, scanning electron microscopy, energy dispersive X-ray analysis, transmission electron microscopy, and X-ray diffraction techniques. Catalytic efficiency of the resultant catalysts was tested in the synthesis of benzochromene derivatives. The experimental studies clarified that the catalyst prepared at 850 °C could efficiently expedite the formation of three-component synthesis of benzochromene derivatives in water at 80 °C with high yields. Indeed, alkali, alkaline metal, and metal oxides such as Al2O3, SiO2, MgO, CaO, and Fe2O3, are widely utilized as both catalyst and catalyst support in the heterogeneous catalytic processes. The prepared wood ash catalysts (possessing metal oxides, e.g., CuO, Al2O3, SiO2, and CaO) could effectively prompt the electrophilic activity of the carbonyl groups during the nucleophilic attack intermediate, enhancing the efficiency of the reactions.
Prevalence and assessment of self-disorders in the schizophrenia spectrum: a systematic review and meta-analysis
Authors: Burgin Sam , Reniers Renate , Humpston Clara 
Published: January 2022

AbstractSelf-disorders have been proposed as the “clinical core” of the schizophrenia spectrum. This has been explored in recent studies using self-disorder assessment tools. However, there are few systematic discussions of their quality and utility. Therefore, a literature search was performed on Medline, Embase, PsychINFO, PubMed and the Web of Science. Studies using these assessment tools to explore self-disorders within schizophrenia spectrum disorders (SSDs) were included. A meta-analysis was performed on the outcomes of total self-disorder score and odds ratios of self-disorders, using Comprehensive Meta-Analysis software. Weighted pooled effect sizes in Hedge’s g were calculated using a random-effects model. 15 studies were included, giving a sample of 810 participants on the schizophrenia spectrum. Self-disorders showed a greater aggregation within schizophrenia spectrum groups compared to non-schizophrenia spectrum groups, as measured with the Bonn Scale for the Assessment of Basic Symptoms (Hedge’s g = 0.774, p < 0.01) and Examination of Anomalous Self-Experiences (Hedge’s g = 1.604, p < 0.01). Also, self-disorders had a greater likelihood of occurring within SSDs (odds ratio = 5.435, p < 0.01). These findings help to validate self-disorders as a core clinical feature of the broad schizophrenia spectrum.
Resultado funcional do procedimento de tenodese extra-articular lateral (TEL) como complemento à reconstrução do ligamento cruzado anterior: Uma metanálise
Authors: Aryana I Gusti Ngurah Wien , Subawa I Wayan , Dusak I Wayan Suryanto , Dharmayuda Cokorda Gde Oka , Nugraha Hans Kristian , Deslivia Maria Florencia 
Published: January 2022

Resumo
Objetivos O objetivo deste estudo é revisar e analisar sistematicamente o desfecho funcional do procedimento de tenodese extra-articular lateral (TEL) em complemento à reconstrução do ligamento cruzado anterior (RLCA) em de estudos com alto nível de evidências.
Métodos Realizamos a pesquisa bibliográfica para estudos clínicos comparando o método TEL como complemento à RCLA com a RLCA isolada. Os resultados principais foram a pontuação no Comitê Internacional de Documentação de Joelho (IKDC, na sigla em inglês), pontuação de Lysholm, e falhas no enxerto. Variáveis contínuas foram relatadas, como médias e intervalos de confiança (ICs) de 95%.
Resultados Seis estudos clínicos com 1,049 pacientes foram incluídos na metanálise. O período de seguimento foi de, em média, 24 meses (intervalo de 6–63 meses). A adição do procedimento TEL à reconstrução do LCA resultou em melhor resultado funcional com base no escore IKDC (p < 0,05). A falha do enxerto foi menor no grupo RLCA mais TEL (16 dos 342 pacientes) em comparação com o grupo apenas RLCA (46 dos 341 pacientes) (p < 0,05).
Conclusão Há evidências de alto nível de que o procedimento TEL como complemento à RLCA é preferível em termos de resultado funcional e falha do enxerto.
Prevalência de dor neuropática em pacientes com fratura da extremidade distal do rádio tratada com placa volar bloqueada
Authors: Silva Helbert Luiz Nomura da , Tanaka Giuliana Olivi , Pinheiro Thiago Barros , Abdouni Yussef Ali 
Published: January 2022

Resumo
Objetivo Avaliar a prevalência de dor persistente no pós-operatório de fratura da extremidade distal do rádio, assim como detectar precocemente sinais de dor neuropática com o intuito de desenvolver protocolos de prevenção da dor crônica pós-operatória.
Métodos Estudo prospectivo, realizado com 56 pacientes submetidos a redução aberta e fixação interna de fratura da extremidade distal do rádio com placa volar bloqueada no período de março a setembro de 2020. Os pacientes foram submetidos a avaliação de dor neuropática e capacidade funcional através dos questionários Douleur Neuropathique 4 questionnaire (DN4) e Quick Disabilities of the Arm, Shoulder, and Hand (Quick-DASH, na sigla em inglês). As variáveis qualitativas foram comparadas pelo teste de Mann-Whitney e sua correlação foi analisada pelos testes de correlação de Spearman e de Igualdade de Duas Proporções.
Resultados Foram incluídos no presente estudo 43 pacientes, com idades entre 18 e 66 anos; 39,5% dos participantes apresentaram pontuação ≥ 4 no questionário Douleur neuropathique 4 questionnaire (DN4). Em relação ao Quick-DASH, a média foi de 38,6. Não houve diferença estatística significante entre o sexo do paciente e o valor do DN4 (p = 0,921). Também não foi encontrada correlação estatística entre as variáveis quantitativas DN4 e Quick-DASH (p = 0,061).
Conclusões A prevalência de dor neuropática nos pacientes pós-operatórios analisados foi significativa e a presença de sinais e sintomas de dor neuropática foi fator preditivo positivo para a persistência da dor além de 2 meses em 100% dos casos. Assim, com diagnóstico precoce do componente neuropático de dor, associado ao componente nociceptivo, é possível obter o controle adequado da dor, impedindo sua cronificação e garantindo uma melhor reabilitação.
Determinação da capacidade de acesso anterior à coluna cervicotorácica conforme idade e gênero: Análise radiográfica de imagens de tomografia computadorizada
Authors: Sugino Rafael Lindi , Iutaka Alexandre Sadao , Cho Samuel K. , Cataldo Daniel R. , Marchi Luis , Herrero Carlos Fernando Pereira da Silva 
Published: January 2022

Resumo
Objetivo A capacidade de acesso anterior à região cervicotorácica com base na idade e gênero do paciente e a possibilidade de variações anatômicas em diferentes populações geográficas ainda não foram investigadas. O objetivo deste trabalho foi realizar uma análise radiográfica de pacientes brasileiros para avaliar a acessibilidade anterior da junção cervicotorácica conforme idade e gênero.
Métodos Análise radiográfica retrospectiva de 300 tomografias computadorizadas. Os pacientes foram separados por idade e gênero. Os parâmetros radiográficos estudados foram: nível horizontal acima do esterno (HLS, na sigla em inglês), angulação do corpo vertebral (VBA, na sigla em inglês), linha do disco intervertebral (IDL, na sigla em inglês) e angulação da linha do disco intervertebral (IDLA, na sigla em inglês).
Resultados Os HLS e IDL mais frequentes foram T2 (34,3%) e C7–T1 (46%), respectivamente. Os valores médios de VBA e IDLA foram de 18 ± 8,94 e 19 ± 7,9 graus, respectivamente. Os homens apresentaram valores maiores de IDLA (p = 0,003) e VBA (p = 0,02). Os grupos de maior idade apresentaram valores maiores de IDLA (p = 0,01) e VBA (p = 0,001). Não houve diferenças de HLS entre os gêneros masculino e feminino (p = 0,3) ou faixas etárias (p = 0,79). Não foram observadas diferenças na IDL entre os gêneros masculino e feminino (p = 0,3); entretanto, o grupo mais velho apresentou nível mais caudal do que os grupos mais jovens (p = 0,12).
Conclusões Em comparação a outras populações, nossa amostra apresentou IDL e HLS mais cefálicos. AVBA e a IDLA foram maiores no gênero masculino, enquanto VBA e IDLA foram maiores em grupos mais velhos. A IDL era mais caudal em pacientes idosos.
Medidas de desfechos clínicos na meniscectomia artroscópica: Pontuações de joelho segundo médicos e pacientes
Authors: Al-Dadah Oday , Shepstone Lee , Donell Simon T. 
Published: January 2022

Resumo
Objetivo O objetivo do presente estudo foi investigar a diferença entre instrumentos de desfechos preenchidos por médicos e pacientes na detecção de melhora após a meniscectomia artroscópica para tratamento de rupturas de menisco.
Métodos Trinta e quatro pacientes com rupturas de menisco foram avaliados de forma prospectiva usando 9 medidas de desfechos clínicos. Os cinco instrumentos de avaliação de joelho respondidos por médicos foram o Escore de Atividade de Tegner, o Escore de Joelho de Lysholm, o Escore de Joelho de Cincinnati, o Escore de Exame do Joelho do International Knee Documentation Committee (IKDC, na sigla em inglês) e o Escore de Classificação do Menisco de Tapper e Hoover. Os quatro instrumentos de avaliação do joelho respondidos por pacientes foram o Escore Subjetivo do Joelho do IKDC, a Pesquisa de Desfecho de Joelho – Escala de Atividades de Vida Diária (KOS-ADLS, na sigla em inglês), o Formulário Curto de Pesquisa em Saúde de 12 Itens (SF-12, na sigla em inglês) e o Escore de Desfecho de Osteoartrite e Lesões no Joelho (KOOS, na sigla em inglês). Vinte e nove dos 34 pacientes foram submetidos a uma meniscectomia artroscópica e reavaliados com todos os 9 instrumentos na sua consulta de acompanhamento.
Resultados Uma melhora longitudinal significativa foi observada em 4 dos 5 instrumentos respondidos por médicos (Tegner [p < 0,001], Lysholm [p = 0,004], Cincinnati [p = 0,002] e Tapper e Hoover [p < 0,001], mas não no IKDC [p = 0,332]). Por outro lado, o Escore Subjetivo do Joelho do IKDC (p = 0,021) foi o único instrumento respondido por pacientes a demonstrar melhora pós-operatória significativa.
Conclusão De modo geral, os instrumentos respondidos por médicos foram considerados inconsistentes em relação àqueles respondidos por pacientes. O modo de administração dos instrumentos pode ter influência significativa nos resultados, tanto para fins de pesquisa quanto para a prática clínica. A combinação de um instrumento respondido pelo médico com um instrumento respondido pelo paciente pode ser uma abordagem mais equilibrada para a avaliação e a quantificação das rupturas do menisco e do desfecho após a meniscectomia artroscópica.
(The) fact is …/(Die) Tatsache ist …focaliser constructions in English and German are similar but subject to different constraints
Authors: Hundt Marianne , Oppliger Rahel 
Published: January 2022

AbstractN-is/istconstructions are elements in the left periphery of English/German sentences that have developed pragmatic meaning: they can be used as discourse markers with various functions, depending on the nominal element that is used in the construction. We use evidence from parallel and comparable corpora of English and German to investigate variable article use in these focaliser constructions and model factors that may play a role in article omission/retention (such as modification, choice of head noun, degree of syntactic integration of the focaliser). Our evidence shows that article use largely depends on the lexical head in German but is constrained by different factors in English (notably modification). We interpret our results against the backdrop of construction grammar, arguing that article omission plays a different role in the two languages. From a contrastive point of view, formal syntactic separation in English is easier to achieve than in German and thus facilitates use of EnglishN-isconstructions as focalisers.
<Th>e ubi<qu>ity of polygra<ph>y and its significan<ce> for <th>e typology of <wr>iti<ng> systems
Authors: Osterkamp Sven , Schreiber Gordian 
Published: January 2022

Abstract
It has often been assumed that there is, or should be, a one-to-one correspondence between graphs and linguistic units in writing systems as the norm. This is not merely doubtful in terms of descriptive accuracy. Conceptualizing writing systems in such a way also has profound consequences for the application of typological categories to specific cases. In this paper we first suggest a working definition of polygraphy, also touching upon its demarcation from adjacent concepts such as ligatures and diacritics. Having demonstrated that polygraphy is in fact fundamental to a significant number of typologically diverse writing systems, we argue in favor of a typology of writing systems taking the ubiquity of polygraphy into due account, with definitions going beyond one-to-one correspondences as the default.
Phononic linear and quadratic nodal points in monolayer XH (X=Si, Ge, Sn)
Authors: Yu Wei-Wang , Liu Ying , Tian Lu , He Tingli , Zhang Xiaoming , Liu Guodong 
Published: January 2022

Abstract
Topological phases in two-dimensional (2D) systems have been attracting tremendous attention since the discovery of graphene. Since the experimental probing could proceed in the whole phonon spectrum, intensive research effort has been devoted to the topological quantum phases in phononic systems. Via first-principles calculations, we predict that a family of 2D hexagonal materials, XH (X = Si, Ge, Sn), hosts ideal linear nodal points (LNPs) and quadratic phononic nodal points (QNPs). Specifically, the LNPs appear at the two inequivalent valleys, akin to the 2D Dirac point in graphene, connecting by an edge arc. The QNP is pinned at the Γ point, two edge states emerge from their projections. Remarkably, both LNPs and QNP enjoy an emergent chiral symmetry, we then show that they feature nontrivial topological charges. As a consequence, our work discusses the nodal points in the phonon spectrum of 2D materials and provides ideal candidates to study the topology for bosonic systems.