bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spielerisch gegen Parkinson
Authors: Mainz Anne 
Published: October 2022

ZUSAMMENFASSUNGDie neurodegenerative Parkinsonerkrankung betrifft vor allem Menschen fortgeschrittenen Alters und mittlerweile knapp 400 000 Menschen in Deutschland. Um die motorischen Symptome von Parkinson zu verbessern, nutzen viele Patienten Therapieangebote. Durch den erkrankungsbedingten Motivationsmangel und starke Erschöpfung fällt es vielen Patienten aber schwer, bei diesen Angeboten längerfristig am Ball zu bleiben. Um die Therapie zu unterstützen, wurde ein Serious-Game-Konzept für die Parkinson-Therapie mithilfe der Design-Thinking-Methode entwickelt. Durch Design Thinking werden nutzerzentrierte Lösungen durch eine systematisierten Kreativprozess entwickelt. Das entstandene Spiel PARKinson ist ein kompetitives Serious Game für 2 Spieler, was durch die Körperbewegungen der Spieler gesteuert wird. Die Bewegungen werden durch kamerabasiertes Bodytracking mithilfe der Azure Kinect erfasst und durch soziales Spielen und den Wettbewerbsgedanken soll die Motivation der Spieler gesteigert und langfristig erhalten werden. Die Ergebnisse dieser Arbeit zeigen, dass eine digitale, spielerische Bewegungstherapie eine geeignete Ergänzung für die Parkinson-Therapie darstellen kann.
Diabetes mellitus im Alter
Authors: Zeyfang Andrej , Wernecke Jürgen , Bahrmann Anke 
Published: October 2022

ZUSAMMENFASSUNGBundesweit gibt es insgesamt etwa 630 000 pflegebedürftige Personen mit Diabetes mellitus. Die Aussagen der Praxisempfehlungen richten sich vorwiegend an die Mehrheit der älteren Menschen mit Typ-2-Diabetes und können nur einen Teil der Besonderheiten des alten Menschen mit Diabetes wiedergeben. Alterstypische Funktionseinschränkungen und eine hohe Vulnerabilität erzeugen besonderen Handlungsbedarf, der über die Blutglukoseeinstellung und das Management kardiovaskulärer Risikofaktoren oder diabetestypischer Komplikationen hinausgeht. Grundsätzlich sind Ziele unter dem Gesichtspunkt der partizipativen Entscheidungsfindung gemeinsam zwischen Arzt und Patienten zu vereinbaren. Der Erhalt der Lebensqualität und das Vermeiden von Hypoglykämien sind vorrangiges Therapieziel. Der HbA1c-Wert hat im höheren Lebensalter einen geringeren Stellenwert bei Therapieentscheidungen. Auch beim älteren Menschen mit Diabetes bilden nichtmedikamentöse Verfahren die Basis der Behandlung. Bei der medikamentösen Therapie soll Metformin auch für ältere Patienten als medikamentöse Therapie der ersten Wahl eingesetzt werden. Technische Hilfsmittel zum Diabetesmanagement für Ältere sind bereits seit vielen Jahren auf dem Markt. Während mechanische Hilfsmittel wie altengerechte Blutzuckermessgeräte oder altengerechte Insulin-Pens bereits eine gute Akzeptanz finden, sind elektronische oder auch digitale Hilfsmittel noch nicht in den breiten Einsatz gelangt. Zu den Pflegeschwerpunkten geriatrischer Patienten mit Diabetes sollen v. a. Folgendes gehören: Hypoglykämievermeidung, Prävention des diabetischen Fußsyndroms, Erfassung von Schmerzen (insbesondere auch mit Blick auf Polyneuropathien), Beobachtung der Haut, Wundassessments und -management sowie Förderung der Mundgesundheit, Erfassung der Ernährungssituation, Kontinenzerhaltung und -förderung und Erfassung von Mobilitätseinschränkungen/Sturzgefahr.
Antipsychotic Monotherapy for Major Depressive Disorder: A Systematic
Review and Meta-Analysis
Authors: Nishi Akira , Sawada Kyosuke , Uchida Hiroyuki , Mimura Masaru , Takeuchi Hiroyoshi 
Published: October 2022

AbstractAlthough several randomized controlled trials (RCTs) have compared the
effectiveness, efficacy, and safety of antipsychotic monotherapy (APM) versus
placebo in patients with major depressive disorder (MDD), no meta-analysis has
examined this topic. We conducted a systematic literature search using MEDLINE
and Embase to identify relevant RCTs and performed a meta-analysis to compare
the following outcomes between APM and placebo: response and remission rates,
study discontinuation due to all causes, lack of efficacy, and adverse events,
changes in total scores on depression severity scales, and individual adverse
event rates. A total of 13 studies were identified, with 14 comparisons
involving 3,197 participants that met the eligibility criteria. There were
significant differences between APM and placebo in response and remission rates
and changes in the primary depression severity scale in favor of APM, and study
discontinuation due to adverse events and several individual adverse events in
favor of placebo. No significant difference was observed in discontinuation due
to all causes. APM could have antidepressant effects in the acute phase of MDD,
although clinicians should be aware of an increased risk of some adverse
events.
Longly-attached cap can contribute to en bloc underwater endoscopic mucosal resection of 20–30 mm colorectal intramucosal lesions
Authors: Iwagami Hiroyoshi , Akamatsu Takuji , Ogino Shinya , Morimura Hiroki , Shimoyama Masayuki , Terashita Tomoko , Nakano Shogo , Wakita Midori , Edagawa Takeya , Konishi Takafumi , Nakatani Yasuki , Yamashita Yukitaka 
Published: October 2022

Abstract
Background and study aims Underwater endoscopic mucosal resection (UEMR) is effective for colorectal intramucosal lesions. The aim of this study was to evaluate whether a longly-attached cap in UEMR improves the en bloc resection rate for 20–30 mm lesions.
Patients and methods We performed a retrospective study at a tertiary institute. Candidates for the study were systematically retrieved from an endoscopic and pathological database from October 2016 to December 2020. We assessed the procedural outcomes with UEMR for lesions ≥ 20 mm in size and the clinical factors contributing to en bloc resection.
Results A total of 52 colorectal lesions that underwent UEMR were included. The median procedure time was 271 (66–1264) seconds. The en bloc resection rate and R0 resection rate were 75 % and 73 %, respectively. Intraprocedural perforation occurred in one (1.9 %) case, but no bleeding occurred. Delayed bleeding occurred in one (1.9%) case, but no delayed perforation occurred. Regarding tumor size, macroscopic type, tumor location, and the presence or absence of a history of abdominal operation, there was no significant difference between the en bloc resection and piecemeal resection groups. The visibility of the whole lesion, a longly-attached cap, and sessile serrated lesions were more frequently observed in the en bloc resection group than in the piecemeal resection group (P < 0.001, P = 0.01, and P = 0.04, respectively). Multivariate analysis showed that a longly-attached cap was the only independent factor associated with en bloc resection (P = 0.02).
Conclusions A longly-attached cap might contribute to en bloc resection.
A Description of the Imaging Innovations for Placental Assessment in Response to Environmental Pollution Study
Authors: Janzen Carla , Lei Margarida Y. Y. , Lee Brian R. , Vangala Sitaram , DelRosario Irish , Meng Qi , Ritz Beate , Liu Jonathan , Jerrett Michael , Chanlaw Teresa , Choi Sarah , Aliabadi Arya , Fortes Precious Ann , Sullivan Peggy S. , Murphy Aisling , Vecchio Giorgia Del , Thamotharan Shanthie , Sung KyungHyun , Devaskar Sherin U. 
Published: October 2022

Objective The aim of Placental Assessment in Response to Environmental Pollution Study (PARENTs) was to determine whether imaging of the placenta by novel multiparametric magnetic resonance imaging (MRI) techniques in early pregnancy could help predict adverse pregnancy outcomes (APOs) due to ischemic placental disease (IPD). Additionally, we sought to determine maternal characteristics and environmental risk factors that contribute to IPD and secondary APOs.
Study Design Potential patients in their first trimester of pregnancy, who agreed to MRI of the placenta and measures of assessment of environmental pollution, were recruited into PARENTs, a prospective population-based cohort study. Participants were seen at three study visits during pregnancy and again at their delivery from 2015 to 2019. We collected data from interviews, chart abstractions, and imaging. Maternal biospecimens (serum, plasma, and urine) at antepartum study visits and delivery specimens (placenta, cord, and maternal blood) were collected, processed, and stored. The primary outcome was a composite of IPD, which included any of the following: placental abruption, hypertensive disease of pregnancy, fetal growth restriction, or a newborn of small for gestational age.
Results In this pilot cohort, of the 190 patients who completed pregnancy to viable delivery, 50 (26%) developed IPD. Among demographic characteristics, having a history of prior IPD in multiparous women was associated with the development of IPD. In the multiple novel perfusion measurements taken of the in vivo placenta using MRI, decreased high placental blood flow (mL/100 g/min) in early pregnancy (between 14 and 16 weeks) was found to be significantly associated with the later development of IPD.
Conclusion Successful recruitment of the PARENTs prospective cohort demonstrated the feasibility and acceptability of the use of MRI in human pregnancy to study the placenta in vivo and at the same time collect environmental exposure data. Analysis is ongoing and we hope these methods will assist researchers in the design of prospective imaging studies of pregnancy.
Key Points
The Association of Prenatal C-Reactive Protein and Interleukin-8 Levels with Maternal Characteristics and Preterm Birth
Authors: Litonjua Augusto A. , Lee-Sarwar Kathleen A. , Chen Yih-Chieh S. , Mirzakhani Hooman , Knihtilä Hanna , Fichorova Raina N. , Luu Ngan , Laranjo Nancy , Jha Anjali , Kelly Rachel S. , Weiss Scott T. 
Published: October 2022

Objective The determinants of preterm birth remain unknown. Excessive maternal inflammation during pregnancy may play an important role in the pathogenesis of preterm birth. Our objective was to describe the association of prenatal levels of proinflammatory C-reactive protein (CRP) and interleukin-8 (IL-8) with preterm birth in participants of the Vitamin D Antenatal Asthma Reduction Trial.
Study Design Five hundred and twenty-eight patients with available samples of both first- and third-trimester plasma were included in this analysis. CRP and IL-8 were measured from maternal prenatal samples. We examined the association between prenatal CRP and IL-8 with maternal health characteristics and the outcome of preterm birth. We also described the patterns of change in CRP and IL-8 from first to third trimester and their association with preterm birth. A subgroup analysis comparing only those with a spontaneous preterm birth phenotype to those with term birth was also performed.
Results Maternal characteristics including lower educational attainment, higher prepregnancy body mass index, gestational diabetes, lower vitamin D, and an unhealthy diet were associated with elevated levels of prenatal CRP and IL-8. Higher third trimester CRP and an increase in CRP from first to third trimester were associated with an increased odds of preterm birth when compared to lower levels of CRP (adjusted odds ratio [aOR] = 1.49, 95% confidence interval: 1.02, 2.23, p = 0.04) or a decrease in CRP over pregnancy (aOR = 3.06, 95% CI = 1.31,7.55, p = 0.01), after adjusting for potential confounders. These associations were strengthened when comparing only patients with spontaneous preterm birth (n = 22) to those with term births.
Conclusion Higher levels of the proinflammatory markers CRP and IL-8 are associated with indicators of poor maternal health and preterm birth. Prenatal CRP levels may reflect maternal prenatal health status and serve as a predictor of preterm birth, especially among those with spontaneous preterm birth.
Key Points
Catalytic Enantioselective Dihalogenation of Alkenes
Authors: Dong Jia-Wei , Cao Ren-Fei , Chen Zhi-Min 
Published: October 2022

AbstractVicinal dihalides not only emerge as reactive intermediates in synthetic organic chemistry, but also are extensively existing in bioactive marine natural products. The dihalogenation of alkenes is the most direct and effective method for the synthesis of vicinal dihalides. Because there is always an exchange process between the chiral haloniums and the unreacted olefins to cause racemization, the development of catalytic enantioselective dihalogenation of alkenes is of great difficulty. Recently, great progress has been made in catalytic asymmetric manner. However, there is a lack of related review of discussions of the mechanisms and reaction systems. This review is aimed at summarizing enantioselective dihalogenation of alkenes, including 1,2-dichlorination, 1,2-dibromination, and 1,2-difluorination, which is expected to encourage more researchers to participate in this field.1	Introduction2	Enantioselective 1,2-Dichlorination and 1,2-Dibromination of Alkenes2.1	Chiral-Boron-Complex-Promoted Enantioselective 1,2-Dichlorination2.2	Organocatalytic Asymmetric 1,2-Dichlorination and 1,2-Dibromination2.3	Chiral-Titanium-Complex-Catalyzed 1,2-Dihalogenation3	Chiral-Iodide-Catalyzed Enantioselective Oxidative 1,2-Difluorination4	Summary and Outlook
Fast Access to 5-Hydroxymethyl Derivatives of 2′-Deoxyuridine Promoted by Acidic Amberlyst 15 Resin
Authors: Guianvarc’h D. , Doisneau G. , Liu D. , Monfret O. , Bourdreux Y. , Urban D. 
Published: October 2022

Abstract5-Hydroxymethyl derivatives of pyrimidine nucleosides are an important class of biologically relevant compounds. In addition, such derivatives and related compounds can be functionalized for various applications. To enable fast, economical, and efficient access to 5-hydroxymethylated derivatives of 2′-deoxyuridine, we report a method for the O-5 chemoselective transformation of unprotected 5-(hydroxymethyl)-2′-deoxyuridine through selective etherification in the presence of an alcohol promoted by acidic Amberlyst 15 resin at room temperature. These mild conditions constitute a significant improvement compared with the harsh conditions previously described. Applied to various primary or secondary alcohols, the reaction showed a broad substrate scope, and 24 C(5)-modified derivatives of 5hmdU were synthesized with good isolated yields. Notably, this efficient procedure represents a straightforward method for preparing (i) several useful building blocks for subsequent chemical ligation by using CuAAC reactions; (ii) natural hypermodified thymidines and analogues, including glycosylated derivatives; and (iii) cyanoethyl-protected 5hmdU, useful for solid-phase oligonucleotide syntheses.
Síndrome interóssea posterior devido a schwannoma – Um relato de caso
Authors: Severo Antônio Lourenço , Alencar Neto Deodoro Máximo de , Lemos Marcelo Barreto , Duarte Matheus Predebon , Tagliari Ivânio 
Published: October 2022

ResumoA síndrome interóssea posterior é a síndrome mais frequente de compressão do nervo radial, com a arcada de Frohse sendo o principal local de compressão. Seus sintomas incluem dificuldades na extensão do dedo e punho, com possível desvio radial. Aqui, apresentamos um caso de síndrome interóssea posterior causada por um schwannoma, um tipo de tumor neurológico.
Heterogeneous Photocatalytic Radical Synthesis of Aryl Allyl Sulfones
Authors: Wang Liang , Zhang Ling-feng 
Published: October 2022

AbstractA photocatalytic synthesis of aryl allyl sulfones by a radical cascade reaction from an aryl diazonium salt, DABCO·(SO2)2 and 3-bromoprop-1-ene has been developed. This reaction employed ­DABCO·(SO2)2 as the SO2 source and a polyaniline–graphitic carbon ­nitride–titanium dioxide composite as the photocatalyst. A series of substrates were tolerated, providing the corresponding products in good yields. Moreover, the photocatalyst could be readily recovered and reused several times with only a slight decrease in its catalytic activity.
Ultrasound-Guided Percutaneous Cryoanalgesia for Pectus Excavatum: When Should It be Applied?
Authors: Velayos María , Alonso Mercedes , Estefanía Karla , Jesus Muñoz Antonio , Torres Raquel , Hernández Francisco , Reinoso Francisco , Torre Carlos De la 
Published: October 2022

Abstract
Introduction The addition of ultrasound-guided percutaneous cryoanalgesia (PCr) for pain management after pectus excavatum (PE) surgery offers a new and advantageous approach. Our aim is to describe our experience with PCr applied on the same day, 24 hours, and 48 hours prior to PE surgery.
Material and Methods Prospective pilot study in patients undergoing ultrasound-guided PCr (2019–2022) was divided into three groups: PCr on the same day of surgery (PCrSD), PCr 24 hours before (PCr24), and PCr 48 hours before (PCr48). We describe the application of technique and data obtained by comparing the three groups.
Results We present 42 patients (25 PCrSD, 11 PCr24, 6 PCr48). PCr24 had a shorter procedure duration than PCrSD (65.8 vs. 91.2 minute; p = 0.048). Related to analgesia, PCr24 and PCr48 showed lower opioid consumption than PCrSD in PCA volume (48.5 and 49.6 vs. 75.1 mL; p = 0.015) and PCA time (23.3 and 23.8 vs. 34.3 hours; p = 0.01). Degree of pain (VAS scale) on the day of surgery and on the second postoperative day was lower in PCr24 and PCr48 than in PCrSD (4 and 2 vs. 5; p = 0.012; 0 and 1 vs. 2; p = 0.01, respectively) as well as shorter hospital stay (3 and 3.5 vs. 5 days; p = 0.021). In addition, PCr24 showed lower opioid consumption and hospital stay than PCr48 (p > 0.05). The greatest savings in hospital costs were obtained in the PCr24 group.
Conclusion PCr48 and PCr24 prior to PE surgery offers lower opioid consumption, less pain and shorter hospital stay than PCrSD. PCr24 is comparable to PCr48, but seems to show advantages and simpler logistics for the patient and the hospital.
A Comparison of Spinal Robotic Systems and Pedicle Screw Accuracy Rates: Review of Literature and Meta-Analysis
Authors: Ong Vera , Swan Ashley Robb , Sheppard John P. , Ng Edwin , Faung Brian , Diaz-Aguilar Luis D. , Pham Martin H. 
Published: October 2022

Abstract
Introduction The motivation to improve accuracy and reduce complication rates in spinal surgery has driven great advancements in robotic surgical systems, with the primary difference between the newer generation and older generation models being the presence of an optical camera and multijointed arm. This study compares accuracy and complication rates of pedicle screw placement in older versus newer generation robotic systems reported in the literature.
Methods We performed a systemic review and meta-analysis describing outcomes of pedicle screw placement with robotic spine surgery. We assessed the robustness of these findings by quantifying levels of cross-study heterogeneity and publication bias. Finally, we performed meta-regression to test for associations between pedicle screw accuracy and older versus newer generation robotic spine system usage.
Results Average pedicle screw placement accuracy rates for old and new generation robotic platforms were 97 and 99%, respectively. Use of new generation robots was significantly associated with improved pedicle screw placement accuracy (p = 0.03).
Conclusion Accuracy of pedicle screw placement was high across all generations of robotic surgical systems. However, newer generation robots were shown to be significantly associated with accurate pedicle screw placement, showing the benefits of upgrading robotic systems with a real-time optical camera and multijointed arm.
Koalas of the Clarke Connors Range
Authors: Ellis W. , Melzer A. , FitzGibbon S. , Hulse L. , Gillett A. , Barth B. 
Published: October 2022

The extent and causes of koala population declines are reported for koalas of southeast Queensland, but less is known about the trajectories of populations in other regions of the state. We describe the koala population of the Clarke Connors Range in central Queensland and contrast elements of their distribution, health and genetics with information from two other study sites in Queensland. Koalas were found across the study area, were mostly located in Eucalyptus drepanophylla or E. tereticornis and had wide variability in ranging movements (2.4–2246 ha). Approximately 40% of females carried young in spring and 3 of 29 koalas sampled returned PCR positive chlamydial swabs (all urogenital). We postulate that sympathetic land management approaches may have enhanced habitat occupancy across some areas of the Clarke Connors Range and concur with anecdotal reports that this is a significant population of koalas in Queensland and potentially one of national importance.
Global profiling of arginine dimethylation in regulating protein phase separation by a steric effect–based chemical-enrichment method
Authors: Wang Qi , Li Zhouxian , Zhang Shenqing , Li Yichen , Wang Yan , Fang Zheng , Ma Yanni , Liu Zhen , Zhang Weibing , Li Dan , Liu Cong , Ye Mingliang 
Published: October 2022

Protein arginine methylation plays an important role in regulating protein functions in different cellular processes, and its dysregulation may lead to a variety of human diseases. Recently, arginine methylation was found to be involved in modulating protein liquid–liquid phase separation (LLPS), which drives the formation of different membraneless organelles (MLOs). Here, we developed a steric effect–based chemical-enrichment method (SECEM) coupled with liquid chromatography–tandem mass spectrometry to analyze arginine dimethylation (DMA) at the proteome level. We revealed by SECEM that, in mammalian cells, the DMA sites occurring in the RG/RGG motifs are preferentially enriched within the proteins identified in different MLOs, especially stress granules (SGs). Notably, global decrease of protein arginine methylation severely impairs the dynamic assembly and disassembly of SGs. By further profiling the dynamic change of DMA upon SG formation by SECEM, we identified that the most dramatic change of DMA occurs at multiple sites of RG/RGG–rich regions from several key SG-contained proteins, including G3BP1, FUS, hnRNPA1, and KHDRBS1. Moreover, both in vitro arginine methylation and mutation of the identified DMA sites significantly impair LLPS capability of the four different RG/RGG–rich regions. Overall, we provide a global profiling of the dynamic changes of protein DMA in the mammalian cells under different stress conditions by SECEM and reveal the important role of DMA in regulating protein LLPS and SG dynamics.