bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Investment: Four Universities’ Experiences with the Spencer Foundation's Research Training Grant Program: A Retrospective
Authors: Neumann Anna , Pallas Aaron M. , Peterson Penelope L. 
Published: February 2022

Background This article serves as a conclusion to a TCR special issue devoted to understanding the impact of the Spencer Foundation's Research Training Grant (RTG) initiative. We examine four case reports prepared by scholars at the University of Wisconsin-Madison, the University of Pennsylvania, the University of California at Los Angeles (UCLA), and Michigan State University, as well as the introductory article prepared by Lauren Jones Young of the Spencer Foundation. Objective To identify a set of principles that might guide the construction and ongoing operation of researcher preparation programs in graduate schools of education, both in the four institutions that generously scrutinized the successes and failures of their own efforts, and in other institutions concerned with preparing education researchers. Research Design Analytic essay Conclusions We recommend that academic leaders not count on researcher preparation programs to drive broader efforts to change their organizations. Second, we place more stock in initiatives that allow students to construct a “personal core” of curricular knowledge that draws on institutional resources rather than a “common core” of knowledge that will carry all students throughout their doctoral studies. Third, we caution that providing some students with differential financial, intellectual, and social resources poses risks for many faculty and students around questions of status and autonomy. And finally, because organizational (bureaucratic) boundaries may not be isomorphic with the boundaries that define meaningful communities of research practice, academic leaders should recognize the strengths and limitations of such boundaries.
Qualities that Attract Urban Youth to After-School Settings and Promote Continued Participation
Authors: Strobel Karen , Kirshner Ben , O'Donoghue Jennifer , Mclaughlin Milbrey 
Published: February 2022

Background/Context Studies carried out over the last two decades have established structured after-school programs as significant contexts for adolescent development. Recent large-scale evaluations of after-school initiatives have yielded mixed results, finding some impact on adolescents’ attitudes toward school but limited impact on their academic performance. One clear conclusion of these studies, however, is that it matters how often and for how long young people spend time in after-school settings. Purpose/Research Question This study describes the features of after-school settings that are most appealing and engaging to youth growing up in low-income communities. Setting Analyses focus on a network of five after-school centers that serve predominantly racial and cultural minority youth living in low-income urban neighborhoods. Participants Participants in the study include 120 youth who varied in their frequency of participation in the after-school centers. Of these participants, 20 were in elementary school, 76 were in middle school, and 24 were in high school. Forty-two percent identified themselves as Asian American, 22% as African American, 13% as Latino/Latina, 7% as European American, and 5% as Filipino, and 10% were categorized as “other” or “unknown.” Research Design This study is a qualitative investigation geared toward understanding young people's subjective experiences and meaning making. Data are drawn principally from focus groups and individual interviews with participants over a 2-year period and supplemented with field work conducted by a team of trained youth ethnographers. Findings Our analysis of these data points to three features of the youth centers that youth identified as valuable: supportive relationships with adults and peers; safety; and opportunities to learn. Results highlight the meaning and significance youth ascribed to each feature, while also underlining the important function that centers with these features play in adolescent development. Conclusions/Recommendations After-school settings have the potential to serve as a unique developmental niche by meeting needs that are not consistently met in other contexts. Young people's descriptions of supports and opportunities also underscore the interrelationships among the positive features they perceived. Researchers, practitioners, and policy makers are encouraged to recognize after-school programs as core contexts of development that should be assessed according to the full spectrum of adolescents’ developmental needs.
The Benefits of Utilizing Continuous Glucose Monitoring of Diabetes Mellitus in Primary Care: A Systematic Review
Authors: Kieu Alexander , King Jeffrey , Govender Romona Devi , Östlundh Linda 
Published: February 2022

Background: Continuous glucose monitoring (CGM) and intermittently scanned CGM (is-CGM) have shown to effectively manage diabetes in the specialty setting, but their efficacy in the primary care setting remains unknown. Does CGM/is-CGM improve glycemic control, decrease rates of hypoglycemia, and improve staff/physician satisfaction in primary care? If so, what subgroups of patients with diabetes are most likely to benefit? Methods: A comprehensive search in seven databases was performed in June 2021 for primary studies examining any continuous glucose monitoring system in primary care. We excluded studies with fewer than 20 participants, specialty care only, or hospitalized participants. The National Heart, Lung and Blood Institute and Grading of Recommendations Assessment, Development and Evaluation were used for the quality assessment. The weighted mean difference (WMD) of HbA1c between CGM/is-CGM and usual care with 95% confidence interval was calculated. A narrative synthesis was conducted for change of time in, above, or below range (TIR, TAR, and TBR) hypoglycemic events and staff/patient satisfaction. Results: From ten studies and 4006 participants reviewed, CGM was more effective at reducing HbA1c compared with usual care (WMD −0.43%). There is low certainty of evidence that CGM/is-CGM improves TIR, TAR, or TBR over usual care. The CGM can reduce hypoglycemic events and staff/patient satisfaction is high. Patients with intensive insulin therapy may benefit more from CGM/is-CGM. Conclusions: Compared with usual care, CGM/is-CGM can reduce HbA1c, but most studies had notable biases, were short duration, unmasked, and were sponsored by industry. Further research needs to confirm the long-term benefits of CGM/is-CGM in primary care.
Three-year trajectories in functional limitations and cognitive decline among Dutch 75+ year olds, using nine-month intervals
Authors: Gardeniers Maura Kyra Maria , van Groenou Marjolein Irene Broese , Meijboom Erik Jan , Huisman Martijn 
Published: February 2022

Abstract
Background
Using longitudinal panel data, we aimed to identify three-year trajectories in cognitive and physical functioning among Dutch older adults, and the characteristics associated with these trajectories.

Methods
We used Group-based Trajectory Modelling with mortality jointly estimated to identify trajectories, using a scale composed of 6 Activities of Daily Living (ADL) as a measure of physical functioning, and the short mini mental status examination (sMMSE) or the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) as a measure of cognitive functioning. Data came from 574 Dutch adults aged 75+, collected in five nine-month measurement waves (2015–2018) for the Longitudinal Aging Study Amsterdam.

Results
For physical functioning five trajectories were identified: ‘high’, ‘moderate’, ‘steeply declining’, ‘gradually declining’, and ‘continuously low’; and for cognitive functioning: ‘high’, ‘moderate’, ‘declining’, and ‘low’. Living in an institution, and being lower educated increased the probability of the two continuously low functioning trajectories, whereas old age and multimorbidity increased the probability of low physical functioning, but multimorbidity decreased the probability of low cognitive functioning. Associations for steeply declining physical functioning were absent. Being older and having multimorbidity increased the probability of gradually declining physical functioning and declining cognitive functioning. A higher prevalence of lung- and heart disease, cancer, and rheumatic disease was found in the gradually declining physical functioning group; and a higher prevalence of diabetes, cerebrovascular accidents, and cancer was found in the declining cognitive functioning group. High and moderate physical functioning and high cognitive functioning were characterized by being younger, community-dwelling, and higher educated. Having multimorbidity negatively predicted high and moderate physical functioning, but was not associated with high and moderate cognitive functioning.

Conclusions
This study identified trajectories comparable to studies that used longer time intervals, showing the consistent presence of heterogeneity in both physical and cognitive trajectories. Co-modelling mortality resulted in bigger group sizes for the more adverse trajectories. The favourable trajectories, containing most of the participants, were mostly characterized by absence of disease. The prevalence of chronic diseases differed between the declining trajectories, suggesting that certain diseases tend to induce cognitive decline rather than physical decline, and vice versa.
Current practice in benzodiazepine receptor agonists deprescribing on acute geriatric wards: a cohort study
Authors: Sibille François-Xavier , Spinewine Anne , Zerah Lorène , Maljean Laurentine , Schoevaerdts Didier , de Saint-Hubert Marie 
Published: February 2022

Abstract
Background
Benzodiazepine receptor agonist (BZRA) use is highly prevalent in hospitalised older people although these drugs are associated with numerous and serious adverse events. Deprescribing can reduce risks associated with chronic BZRA use. The aim of this study was to measure the prevalence of, and factors associated with, BZRA deprescribing in acute geriatric units.

Methods
During a one-year period, this multicentre retrospective study included patients aged ≥70 years, hospitalised in acute geriatric units, and using ≥1 BZRA on admission. BZRA deprescribing at discharge was defined as: ≥25% decrease in lorazepam-equivalent admission dose; discontinuation of all BZRAs; or cessation of a rescue prescription at discharge. BZRA cessation was defined as discontinuation of all BZRAs at discharge. We identified social, medical, geriatric and medication factors associated with BZRA deprescribing using logistic regression.

Results
In total, 561 patients were included (mean age: 85.3±5.9 years, 70% of women). BZRA deprescribing occurred in 240 (42.8%), including 85 with BZRA cessation (15.2%). Deprescribing occurred more frequently in patients with a BZRA-related adverse event on admission or during hospital stay (odds ratio (OR) 4.5; 95% confidence interval [2.6; 7.9]), with an antidepressant (1.6 [1.1; 2.4]) and a higher lorazepam-equivalent dosage on admission (OR 1.2 [1; 1.4]), and less frequently in patients with antipsychotic drug (OR 0.5 [0.3; 0.8]). BZRA cessation was more likely in patients with a BZRA-related adverse event (OR 2.2 [1.2; 4.3]) and a lower lorazepam-equivalent dosage on admission (OR 0.5 [0.3; 0.6]).

Conclusions
During hospitalisation in the acute geriatric units of our hospital, BZRA deprescribing occurred in 42.8% of the patients. Identification of an BZRA-related adverse event by the treating physician appears to be a major factor: this reactive deprescribing accounted for 74% of cases in our study. Further prospective studies are needed to measure long-term persistence of in-hospital deprescribing and encourage proactive management.
Loneliness and social isolation among the older person in a Swiss secure institution: a qualitative study
Authors: Pageau Félix , Seaward Helene , Habermeyer Elmar , Elger Bernice , Wangmo Tenzin 
Published: February 2022

Abstract
Background
A pandemic of loneliness is hitting the aging population. As COVID19 forced us to isolate ourselves, we are in a better position to understand consequences of social distancing. The recent literature showed that older incarcerated adults are particularly at risk of health-related complications due to isolation in the prison environment, reducing their social capital. Mental and physical health can be severely affected by loneliness and social isolation, especially in prison.

Methods
Our qualitative study investigates the view of older persons deprieved of their liberty on loneliness and social isolation pertaining to their mental health. We interviewed 57 older participants, including imprisoned individuals and forensic patients, following a semi-structured interview guide. During the data management and data analysis process, we excluded 7 interviews which were of poorer quality. Thereafter, we analyzed the remainders following a thematic approach.

Results
Most interviewees experience loneliness following lack of significant human relationships in prison. Making friends appears to be a challenge for all the participants, because, for one thing, they do not find people with similar interests. Also, secure institution setting aggravates isolation due to the restrictions of movement placed such as rules concerning movement between floors, hindering intimate relationship, and separation between friends. Moreover, contact with prison personnel is limited and lack social capital (e.g. trust).

Conclusion
To our knowledge, this study is one of the first to present incarcerated persons’ perspective on loneliness, social isolation and poor social capital in the Swiss prison setting. These has been reported to cause health problems both somatic and psychological. Our participants experience these deleterious factors in detention. As prisons have the possibility to become a health-promoting environment through connectedness, friendship, and trust promotion, stakeholders need to better their social capital.
Role of the T2Dx magnetic resonance assay in patients with suspected bloodstream infection: a single-centre real-world experience
Authors: Quirino Angela , Scaglione Vincenzo , Marascio Nadia , Mazzitelli Maria , Garofalo Eugenio , Divenuto Francesca , Serapide Francesca , Bruni Andrea , Lionello Rosaria , Pavia Grazia , Costa Chiara , Giancotti Aida , Peronace Cinzia , Longhini Federico , Russo Alessandro , Liberto Maria Carla , Matera Giovanni , Torti Carlo , Trecarichi Enrico Maria 
Published: February 2022

Abstract
Background
T2Dx was approved by the US Food and Drug Administration for the rapid detection of a modified panel of ESKAPE bacterial species or Candida spp. causing bloodstream infection (BSI).

Patients and methods
We performed a retrospective, observational study from January 1, 2018 to December 31, 2019 of all hospitalised patients with suspected BSI who underwent assessment using T2Dx in addition to standard blood culture (BC). T2-positive patients (cases) were compared to a matched group of patients with BSI documented only by BC (1:2 ratio) to investigate the possible impact of T2Dx on the appropriateness of empirical antimicrobial therapy and 21-day mortality.

Results
In total, 78 T2Dx-analysed samples (49 patients) were analysed. The T2Dx assay result was positive for18 patients and negative for 31 patients. The concordance rates of the T2Bacteria Panel and T2Candida Panel results with those of standard BC were 74.4% and 91.4%, respectively. In the matched analysis, inappropriate empiric antimicrobial therapy administration was significantly less frequent in cases than in comparators (5.5% vs. 38.8%). The 21-day mortality rate was twofold lower in cases than in comparators (22.2% vs. 44.4%), although the difference was not significant. No other analysed variables were significantly different between the two groups.

Conclusions
This study illustrated that T2Dx might be associated with an increase in the appropriateness of empiric antimicrobial therapy in patients with BSI. Further studies are needed to evaluate whether the T2Dx assay can improve patient outcomes.
Pregnancy outcomes and associated factors for uterine rupture: an 8 years population-based retrospective study
Authors: Wan Sheng , Yang Mengnan , Pei Jindan , Zhao Xiaobo , Zhou Chenchen , Wu Yuelin , Sun Qianqian , Wu Guizhu , Hua Xiaolin 
Published: February 2022

Abstract
Background
Uterine rupture is an obstetrical emergency with serious undesired complications for laboring mothers resulting in fatal maternal and neonatal outcomes. The aim of this study was to assess the incidence of uterine rupture, its association with previous uterine surgery and vaginal birth after caesarean section (VBAC), and the maternal and perinatal implications.

Methods
This is a population-based retrospective study. All pregnant women treated for ruptured uterus in one center between 2013 and 2020 were included. Their information retrieved from the medical records department were reviewed retrospectively.

Results
A total of 209,112 deliveries were included and 41 cases of uterine rupture were identified. The incidence of uterine rupture was 1.96/10000 births. Among the 41 cases, 16 (39.0%) had maternal and fetal complications. There were no maternal deaths secondary to uterine rupture, while perinatal fatality related to uterine rupture was 7.3%. Among all cases, 38 (92.7%) were scarred uterus and 3 (7.3%) were unscarred uterus. The most common cause of uterine rupture was previous cesarean section, while cases with a history of laparoscopic myomectomy were more likely to have serious adverse outcomes, such as fetal death. 24 (59.0%) of the ruptures occurred in anterior lower uterine segment. Changes in Fetal heart rate monitoring were the most reliable signs for rupture.

Conclusions
Incidence of uterine rupture in the study area, Shanghai, China was consistent with developed countries. Further improvements in obstetric care and enhanced collaboration with referring health facilities were needed to ensure maternal and perinatal safety.
Baseline blood count levels increase odds of cytopenia among CML patients in Kenya: a case control study
Authors: McLigeyo Angela , Rajab Jamilla , Oyiro Peter , Ezzi Mohammed , Bett Yatich , Ong’ondi Matilda , Odhiambo Andrew , Mwanzi Sitna , Othieno-Abinya Nicholas 
Published: February 2022

Abstract
Background
Imatinib is the gold standard for the treatment of all phases of Philadelphia positive Chronic Myeloid Leukemia (CML). During treatment, patients may develop cytopenia. We aimed to study the baseline characteristics and factors associated with cytopenia at a Nairobi Hospital.

Methods
This was a retrospective case-control study of patients aged ≥18 years on follow-up at the Glivec International Patient Access Program (GIPAP) clinic from 2007 to 2015. The cases consisted of CML patients on imatinib who developed cytopenia. The controls were CML patients on imatinib who did not develop cytopenia. Baseline socio – demographic, clinical, hematologic, and molecular data were retrieved from patients’ files. Chi square or fishers’ exact tests were used to analyze for differences between cytopenia and no cytopenia. Binary logistic regressions were employed to identify relationships. Univariate and multivariate analyses were done to identify independent predictors of cytopenia. Odds ratios (OR) were presented including the 95% confidence intervals and respective p values.

Results
A total of 201 patients were studied consisting of ninety-four (94) patients with cytopenia and 107 with no cytopenia. Among the entire population, males were 52, and 42% were aged 36–50 years. Sex, age, marital status, occupation and education level were similar between the cytopenia and no cytopenia groups.
Among the 201 patients, 70% had symptoms for > 12 months before diagnosis, 78.6% had B symptoms at baseline, 80% had a moderate splenomegaly at baseline.
Among patients with cytopenia, 40 and 37.4% developed cytopenia within 3 months and 3–6 months respectively after imatinib initiation. Baseline neutrophilia, neutropenia, anaemia, thrombocytosis, thrombocytopenia was found in 68, 11, 11, 23.5 and 11% respectively. Baseline hemoglobin, neutrophil and platelet level were significantly different between the cytopenia and the no cytopenia group. On univariable analysis, baseline anemia with hb < 7.9 g/dL (p = 0.002), neutropenia (p = 0.001), neutrophilia > 100,000/mm3 (p = 0.002) and thrombocytopenia (p = 0.001) increased the odds of developing cytopenia. On multivariable analysis, baseline anaemia (p value < 0.002), neutropenia (p value < 0.001), thrombocytopenia (p value, < 0.001) and thrombocytosis (p value, 0.033) increased the odds of developing cytopenia.

Conclusion
Odds of cytopenia were higher in presence of baseline cytopenia and thrombocytosis. Clinicians should have a high index of suspicion for these patients.
Nutrient intake, dietary patterns, and anthropometric variables of children with ADHD in comparison to healthy controls: a case-control study
Authors: Salvat Habibeh , Mohammadi Mehriar Nader , Molavi Parviz , Mostafavi Seyed Ali , Rostami Reza , Salehinejad Mohammad Ali 
Published: February 2022

Abstract
Background
Poor health behaviors and variables are recently more documented in attention-deficit hyperactivity disorder (ADHD) lifestyle which might be relevant to the pathophysiology of this disorder. The objective of this case-control study was to assess the nutrient intake, dietary patterns, and anthropometric variables in children with ADHD compared to normal peers.

Method
One hundred children diagnosed with ADHD were included and compared to 100 healthy, sex-matched normal children as the control group. Anthropometric indices, macronutrients, and micronutrients were measured and compared in both groups.

Results
ADHD children were significantly consuming more simple sugars, tea, ready-made meals but less protein, vitamin B1, vitamin B2, vitamin C, zinc and calcium compared to the control group. The body mass index (BMI) and waist circumference of children with ADHD were significantly higher and were related to the severity and type of the disease.

Conclusion
Unhealthy eating behavior is more frequent in children with ADHD, compared to normal children which might warrant lifestyle intervention in this disorder.