bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypothetical model for on‐the‐job training through case conferences of public health nurses
Authors: Sato Taichi , Ishimaru Mina 
Published: July 2022

AbstractPublic health nurses (PHNs) face difficulties supporting vulnerable individuals and families. On‐the‐job training (OJT) is essential for improving nurses’ competencies. However, PHN managers lack the knowledge to systematically implement OJT. The aim of this study was to develop a hypothetical model to systematically promote OJT for PHNs through case conferences (CC). Literature review, based on an integrative approach, has three stages: (1) theoretical framework development, (2) literature review, and (3) modeling. Literature review from five databases (MEDLINE, CINAHL, PsycInfo, Cochrane Central Register of Controlled Trials, Japan Medical Abstract Society) was conducted to identify the OJT process, its outcomes, and the conditions associated with OJT according to the theoretical framework. Based on 18 articles, this model progressed from “OJT process through CC,” comprising the CC design, implementation, and evaluation to OJT produced “outcomes through CC.” Outcomes included staff perception and behavior changes, improvements in client's condition, and staff turnover reductions. The OJT model involved “conditions for implementing CC as OJT” and “individual and organizational conditions.” Future research should incorporate the social, political, and historical contexts of specific practice situations into the hypothetical model to help refine the model to be used in practice.
Theopoetics as Radical Political TheologyTheopoetics and Religious Difference: The Unruliness of the Interreligious: A Dialogue with Richard Kearney, John D. Caputo, and Catherine Keller, MariusvanHoogstraten, Mohr Siebeck, 2020 (ISBN 978‐3‐16‐159800‐5), xi + 260 pp., pb €84Sovereignty and Event: The Political in John D. Caputo's Radical Theology, Calvin D.Ullrich, Mohr Siebeck, 2021 (ISBN 978‐3‐16‐159230‐0), xii + 273 pp., pb €94
Authors: Novak Mark 
Published: July 2022

AbstractThis paper examines works in two of the major streams of thought in contemporary Continental philosophy of religion and theology—theopoetics and political theology—that loosely hang together by two shared threads: philosopher‐cum‐(radical)theologian John D. Caputo and the question of how to live well with the Other. After examining each book in turn, I weave their thoughts together showing how both theopoetics and radical political theology have the same shared aim. This aim is, namely, to deconstruct harmful and outdated narratives about God that have created unjust political systems and relations with other religions, to in turn continually ‘make‐true’ the democracy to‐come.
Identification of Mistuning Based on Forced Response Measurements and Assessment for a Real Compressor Blisk
Authors: Seeger Benjamin , Kohlmann Lukas , Schoenenborn Harald , Schwarz Stefan , Krack Malte 
Published: July 2022

Abstract
We develop a novel method for the identification of mistuned blisks. The method relies on forced response measurements in a certain target frequency band. Modal stiffness deviations and an overall structural damping coefficient are obtained using a least-squares fit, fully consistent with a component-mode-based reduced-order model. To achieve a high frequency resolution in a very short test, we carry out rapid frequency sweeps and use a noise-robust, wavelet-based estimation of the steady-state response. The forcing is eliminated from the equations governing the mistuning parameters, and it is identified separately to reconstruct the forced response if requested. We first validate the method numerically and then apply it experimentally to a compressor blisk with an alternating (B-A) mistuning pattern. While most previous works on mistuning identification are limited to the lowest 1-2 mode families, we assess the method for the seventh (1C) and eighth (3T) mode family. Measured and reconstructed frequency responses are in good to very good agreement. We conclude that the developed method is useful to obtain high-quality estimates of mistuning parameters, which can then be used for vibration prediction.
Mercury evidence of Deccan volcanism driving the Latest Maastrichtian warming event
Authors: Li Sha , Grasby Stephen E. , Zhao Xiangdong , Chen Jiubin , Zheng Daran , Wang He , Fang Yanan , Zhang Qi , Yu Tingting , Tian Jingxiang , Du Shengxian , Jarzembowski Edmund A. , Wang Qifei , Zhang Haichun , Wan Xiaoqiao , Wang Bo 
Published: July 2022

Abstract
The timing and ecological impacts of the Deccan Traps large igneous province eruption are vigorously debated. Pre–Cretaceous-Paleogene (KPg) boundary impacts of Deccan volcanism have been widely identified in marine sediments, but direct evidence of terrestrial impacts remains rare. We used mercury concentrations and isotopic compositions, a proxy for volcanic activity, to assess impacts on terrestrial environments. We studied two drill cores across the KPg boundary in eastern China that represent two different depositional environments: clastic deposits in the Jiaolai Basin and carbonate deposits in the Pingyi Basin. Both drill cores exhibit strong Hg enrichment prior to the KPg boundary. Near consistent mass-independent fractionation (MIF) of odd-Hg isotopes (odd-MIF) in the Jiaolai Basin likely indicates a volcanogenic source of Hg spikes below the KPg boundary. Odd-MIF isotopes in the Pingyi Basin likewise suggest a volcanogenic Hg source but with a terrestrial Hg signature of lower Δ199Hg values before and after the Hg spike interval. The Hg enrichment level can be stratigraphically correlated to the beginning of the Latest Maastrichtian warming event (LMWE) and is consistent with a strong, negative carbon-isotope excursion (CIE) in both δ13Corg (organic matter) and δ13Ccarb (carbonate), suggesting a disturbance of the global carbon cycle induced by a major pulse of Deccan Traps volcanism. Our discovery of a ter-restrial record of pre-KPg boundary Deccan volcanism provides robust evidence of global influence of the Deccan Traps large igneous province during the LMWE.
Hydrodynamic invalidation of synformal traps for dissolved CO2
Authors: Stewart S.A. , Riddell L.A. 
Published: July 2022

Abstract
Reservoirs with the geometry of structural lows trap negatively buoyant fluids, mirroring the way structural highs trap positively buoyant fluids. In both scenarios, lateral flow of reservoir water alters the trapping geometry by causing fluid contacts to tilt. Tilt increases in proportion to hydraulic head gradient increases and the density contrast between the flowing and trapped fluids decreases. Positively buoyant, immiscible supercritical CO2 is at least 20% lighter than typical saline formation waters at CO2 subsurface storage pressures and temperatures, and would experience relatively low tilts, &lt;1°, similar to hydrocarbon fields. On the other hand, CO2-saturated brines are within 1% of the density of CO2-free equivalent brine. This relatively low density contrast creates tilted contacts at much higher angles even at the low hydraulic head gradients that typify deep saline aquifers. For example, a fluid contact with 0.5% density contrast exceeds 2° tilt for hydraulic head gradients of only 15 cm/km. Many large and basin-scale synformal traps are formed with structural dips of just a few degrees and therefore cannot trap CO2 solutions under hydrodynamic conditions. This problem could be overcome by utilization of hydrodynamic traps or appropriately configured structural-stratigraphic traps for CO2 sequestration.
Effect of home-based childcare on childhood mortality in rural Maharashtra, India: a cluster randomised controlled trial
Authors: Satav Ashish Rambhau , Satav Kavita Ashish , Bharadwaj Abhijeet , Pendharkar Jayashree , Dani Vibhawari , Ughade Suresh , Raje Dhananjay , Simões Eric A F 
Published: July 2022

BackgroundMelghat, an impoverished rural area in Maharashtra state, India; has scarce hospital services and low health-seeking behaviour. At baseline (2004) the under-five mortality rate (U5MR) (number of deaths in children aged 0–5 years/1000 live births) was 147.21 and infant mortality rate (IMR) (number of deaths of infants aged under 1 year/1000 live births) was 106.6 per 1000 live births. We aimed at reducing mortality rates through home-based child care (HBCC) using village health workers (VHWs).MethodsA cluster-randomised control trial was conducted in 34 randomly assigned clusters/villages of Melghat, Maharashtra state, between 2004 and 2009. Participants included all under-five children and their parents. Interventions delivered through VHWs were patient–public involvement, newborn care, disease management and behaviour change communications. Primary outcome indicators were U5MR and IMR. Secondary outcome indicators were neonatal mortality rate (NMR) (number of neonatal deaths aged 0–28 days/1000 live births) and perinatal mortality rate (PMR) (number of stillbirths and early neonatal deaths/1000 total births). Analysis was by intention-to-treat at the individual level. This trial was extended to a service phase (2010–2015) in both arms and a government replication phase (2016–2019) only for the intervention clusters/areas (IA).FindingsThere were 18 control areas/clusters (CA) allocated and analysed with 4426 individuals, and 16 of 18 allocated IA, analysed with 3230 individuals. The IMR and U5MR in IA were reduced from 106.60 and 147.21 to 32.75 and 50.38 (reduction by 69.28% and 65.78%, respectively) compared with increases in CA from 67.67 and 105.3 to 86.83 and 122.8, respectively, from baseline to end of intervention. NMR and PMR in IA showed reductions from 50.76 to 22.67 (by 55.34%) and from 75.06 to 24.94 (by 66.77%) respectively. These gains extended to villages in the service and replication phases.InterpretationThis socio-culturally contextualised model for HBCC through VHWs backed up with institutional support is effective for significant reduction of U5MR, IMR and NMR in impoverished rural areas. This reduction was maintained in the study area during the service phase, indicating feasibility of implementation in large-scale public health programmes. Replicability of the model was demonstrated by a linear decline in all the mortality rates in 20 new villages during the government phase.Trial registration numberNCT02473796.
Associations between long term air pollution exposure and first hospital admission for kidney and total urinary system diseases in the US Medicare population: nationwide longitudinal cohort study
Authors: Lee Whanhee , Wu Xiao , Heo Seulkee , Fong Kelvin C , Son Ji-Young , Sabath M Benjamin , Braun Danielle , Park Jae Yoon , Kim Yong Chul , Lee Jung Pyo , Schwartz Joel , Kim Ho , Dominici Francesca , Bell Michelle 
Published: July 2022

ObjectiveTo estimate the associations between long term exposure to air pollution and the first hospital admission related to kidney and total urinary system diseases.DesignNationwide longitudinal cohort study.SettingData were collected from the Medicare fee-for-service for beneficiaries living in 34 849 zip codes across the continental United States from 2000 to 2016. Exposure variables were annual averages of traffic related pollutants (fine particles (PM2.5) and nitrogen dioxide (NO2)) that were assigned according to the zip code of residence of each beneficiary with the use of validated and published hybrid ensemble prediction models.ParticipantsAll beneficiaries aged 65 years or older who were enrolled in Medicare part A fee-for-service (n=61 097 767).Primary and secondary outcome measuresFirst hospital admission with diagnosis codes for total kidney and urinary system disease or chronic kidney disease (CKD), analyzed separately.ResultsThe average annual concentrations of air pollution were 9.8 µg/m3for PM2.5and 18.9 ppb for NO2. The total number of first admissions related to total kidney and urinary system disease and CKD were around 19.0 million and 5.9 million, respectively (2000-16). For total kidney and urinary system disease, hazard ratios were 1.076 (95% confidence interval 1.071 to 1.081) for a 5 µg/m3increase in PM2.5and 1.040 (1.036 to 1.043) for a 10 ppb increase in NO2. For CKD, hazard ratios were 1.106 (1.097 to 1.115) for a 5 µg/m3increase in PM2.5and 1.013 (1.008 to 1.019) for a 10 ppb increase in NO2. These positive associations between PM2.5and kidney outcomes persisted at concentrations below national health based air quality standards.ConclusionsThe findings suggest that higher annual air pollution levels were associated with increased risk of first hospital admission related to diseases of the kidney and urinary system or CKD in the Medicare population.
Association between gout and cardiovascular outcomes in adults with no history of cardiovascular disease: large data linkage study in New Zealand
Authors: Cai Ken , Wu Billy , Mehta Suneela , Harwood Matire , Grey Corina , Dalbeth Nicola , Wells Susan Mary , Jackson Rod , Poppe Katrrina 
Published: July 2022

ObjectiveTo examine the association of gout with cardiovascular outcomes using linked administrative health data in Aotearoa New Zealand.DesignData linkage study.SettingNational registries of pharmaceutical dispensing, hospital admission, and deaths linked to the Auckland/Northland regional repository of laboratory results to create a regional health contact population as of 31 December 2011.Participants942 416 residents of the Auckland/Northland region, aged 20-79 years with no history of cardiovascular disease.Main outcome measuresTime to first fatal or non-fatal cardiovascular event, identified from national datasets on hospital admissions and mortality, between 1 January 2012 and 31 December 2016. Cardiovascular disease was broadly defined as comprising ischaemic heart disease, ischaemic or haemorrhagic stroke, transient ischaemic attack, peripheral vascular disease, and heart failure.InterventionsA history of gout identified from a discharge diagnosis of gout from a public hospital admission or previous dispensing of gout specific drug treatments. The cohort was then linked to national hospital admissions and deaths through to 31 December 2016 (ie, 5 years' follow-up). Multivariable Cox proportional hazard models were constructed to assess the associations between gout, other risk factors, and cardiovascular outcomes.ResultsOf 942 416 people included in the study, 31 907 (3.4%) had gout (6261 women and 25 646 men). After adjustment for multiple risk factors for cardiovascular disease, gout was associated with increased cardiovascular events (adjusted hazard ratio 1.34 (95% confidence interval 1.23 to 1.45) in women; 1.18 (1.12 to 1.24) in men). For men with gout, there was an increased risk of cardiovascular disease in those who were not dispensed regular allopurinol (1.15 (1.05 to 1.25)) and those with a serum urate above the treatment target of 0.36 mmol/L (1.16 (1.04 to 1.30)). Risk of cardiovascular events was lower for men with gout who were not dispensed colchicine compared with those who were (0.84 (0.77 to 0.92)). These findings were not observed in women.ConclusionThese results indicate that gout is associated with an increased risk of cardiovascular events. In men with gout without history of cardiovascular disease, the cardiovascular risk was lower in those regularly dispensed allopurinol and those with serum urate levels at the recommended treatment target. By contrast, colchicine dispensing was associated with an increased risk of cardiovascular events in men with gout without a cardiovascular history. The potential causal mechanisms of these associations require further exploration, including casual inference modelling in future studies.
Differential associations of lipoprotein(a) level with cerebral large artery and small vessel diseases
Authors: Pan Yuesong , Cai Xueli , Jing Jing , Wang Suying , Meng Xia , Mei Lerong , Yang Yingying , Jin Aoming , DongXiao Yao , Li Shan , Li Hao , Wei Tiemin , Wang Yongjun , Wang Yilong 
Published: July 2022

Background and purposeCerebral large artery and small vessel diseases are related to different pathogenetic mechanisms and have different risk factor profile. Lipoprotein(a) (Lp(a)) was shown to promote atherosclerosis but data was limited on its association with cerebral small vessel diseases (cSVD). The objective of this study was to assess the associations of Lp(a) level with the two types of cerebrovascular diseases.MethodsCommunity-dwelling subjects aged 50–75 years from the baseline survey of The PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events study were included. Lp(a) concentrations was measured and categorised into three groups according to the tertiles. Eligible participants were scanned by a 3.0T MRI scanner and assessed for intracranial atherosclerosis and cSVD burden based on four imaging markers.ResultsThis study included 3059 subjects. The average age of the participants was 61.2±6.7 years, and 53.5% (1636) were female. Compared with the first tertile, subjects with the second and third tertiles of Lp(a) concentrations were associated with an increased odds of presence of intracranial plaque (18.7% vs 15.4%, adj.OR 1.37, 95% CI 1.08 to 1.75; 18.9% vs 15.4%, adj.OR 1.34, 95% CI 1.05 to 1.72). Similar associations were observed for intracranial atherosclerotic burden. Whereas, subjects with the third tertile of Lp(a) level had a decreased odds of presence of cSVD (25.9% vs 31.7%, adj.OR 0.74, 95% CI 0.60 to 0.92) and lower cSVD burden (adj.cOR 0.76, 95% CI 0.62 to 0.94).ConclusionsIn this study, Lp(a) concentrations were positively associated with presence and burden of intracranial atherosclerosis, but was inversely associated with cSVD.Trial registration numberNCT03178448.
Preoperative Assessment of Patients Undergoing Bariatric Sleeve Gastrectomy: A Cross-Sectional Study
Authors: Tawfik M. R. , Aldawas N. F. , Almegbil N. S. , Bin Hamad A. A. , Alanazi A. N. , Alaidaroos A. M. , AlRawaf T. M. , Fayed A. A. 
Published: July 2022

Introduction. Saudi Arabia (SA) is one of the top countries in the world when it comes to the number of bariatric procedures performed each year. There is still some debate on whether to do regular or selective upper endoscopy during the preoperative examination. The purpose of this study was to explore various endoscopic findings and Helicobacter pylori (HP) infection in symptomatic and asymptomatic patients having laparoscopic sleeve gastrectomy (LSG) prior to surgery. Methods. We investigated a cohort of 132 patients referred to the endoscopy unit from the bariatric surgery outpatient clinic for prebariatric esophagogastroduodenoscopy (EGD) as a part of preoperative LSG. Data extraction from medical records included clinical data such as body mass index (BMI), gastrointestinal symptoms (that include heartburn, regurgitation, epigastric pain, and nausea), medical comorbidities, and laboratory investigations. It included data about the endoscopic findings of EGD procedure as esophageal, gastric, and duodenal findings results as well as the results of biopsy specimens that were taken. Results. Out of 132 patients, 29 (22%) had a BMI of less than 40 kg/m2 whereas 103 (78%) had a BMI of 40 kg/m2 or above, with an average of

44.4
±
6.4

kg/m2. The average age of participants was

33.6
±
10.4

years. HP was detected in 36 patients (35.0%) with a slightly greater prevalence in patients with a higher BMI (33.7%) than in patients with lower BMI (35.0%). Collectively, 73 patients (55.7%) had positive endoscopic findings of various grades, sites, and combinations. Incompetent cardia (35.6%) was the most often seen esophageal finding, antral gastritis (34.1%) was the most frequently encountered gastric finding, and duodenitis 1st part was the commonest duodenal endoscopic finding (7.8%). Among asymptomatic patients, incompetent cardia was detected in 33.3%, antral gastritis was found in 30.1%, and around one-quarter of them were positive on HP testing (26.6%). Additionally, 16.1% of them had signs of reflux esophagitis, 17.2% had hiatal hernia, and 14.0% had nodular gastritis. Conclusion. The current study revealed a high prevalence of positive endoscopic findings as well as HP infection upon routine endoscopic examination among patients undergoing bariatric surgery even those who were asymptomatic from any gastrointestinal symptoms.
Antitumor CAR T-cell Screening Platform: Many Are Called, but Few Are Chosen
Authors: Adotévi Olivier , Galaine Jeanne 
Published: July 2022

Abstract
Treatment with T cells expressing chimeric antigen receptors (CAR) is a promising anticancer therapy. However, this approach has several limitations and has not yet been effectively applied to treat solid tumors. The study by Panowski and colleagues represents the first comparative analysis of multiple single chain fragment variable (scFv)-based anti-CD70 CAR T-cell clones for the development of a clinical product to treat renal cell carcinoma (RCC). Despite the risk of T-cell fratricide due to CD70 expression on T cells, CD70 CAR T cells were produced successfully thanks to the protective CD70 masking phenomenon. Two distinct classes of CAR T cells were identified with different memory phenotypes, activation statuses, and cytotoxic activity. CD70 CAR T cells presented high cytotoxic activity against RCC both in vitro in RCC cell lines and in vivo in patient-derived xenograft mouse models. The off-target effects expected on the lymphoid compartment were confirmed by tissue cross-reactivity staining and in a cynomolgus monkey preclinical model with CD3-CD70 bispecific antibody treatment. The efficacy and the toxicity profile of the lead CD70 CAR T-cell candidate instigated the researchers to proceed with upscaled clinical production. This article emphasizes the influence of the scFv of the CARs on their efficacy:toxicity balance. Ultimately, they successfully managed to develop a highly effective CAR T-cell candidate to treat a solid tumor by an allogeneic approach, thereby overcoming two major hurdles to broaden application of CAR T-cell therapy.
See related article by Panowski et al., p. 2610