bluuebunny/crossref_metadata_2025_split huggingface dataset:
LIMBERG FLAP TECHNIQUE FOR PILONIDAL SINUS DISEASE TREATMENT: AN EXPERIENCE OF HAMDARD UNIVERSITY HOSPITAL
Authors: Zubair Rabbia , Channa Muhammad Ali 
Published: April 2022

Background: Pilonidal sinus disease (PNSD) is considered as the challenging disease for surgeons since decades. The term pilo-nidal is derived from Latin meaning “nest of hair”. It is a commonly occurring disease usually involved young male adults. It is considered as an acquired condition with unidentified aetiology and pathogenesis. The objective was to observe the results of Limberg’s flap operation in patients with Pilonidal sinus disease. Methods: We performed an observational study at Hamdard University Hospital from 1st January 2016 to 31st December 2019 on patients who came to the outpatient department for the treatment of pilonidal sinus diseases and underwent surgery (Limberg’s flap) after consent. The patient’s presentation varied from single sinus and dry, multiple sinuses and dry, single sinus with serous discharge, single sinus with pus discharge, and pilonidal abscess. Forty-six patients were selected after applying inclusion and exclusion criteria and operated by Limberg’s flap technique. Result: Results were observed for postoperative seroma, hematoma, wound infection, persistent pain, and recurrence. Out of 46 patients, 30 (65.21%) were male and 16 (34.7%) were female. 28 patients (60.8%) were between 31–40 years of age and 12 patients (26.08%) were between 41–50 years of age. After performing Limberg’s flap procedure, 35 patients (76%) had no complications at all. 2 patients (4.3%) had seroma formation. 4 patients had Hematoma formation (8.6%). Two patients (4.3%) patients developed superficial wound infection. 2 patients (4.3%) had persistent pain after 3 months of the procedure. One patient (2.1%) had recurrence during the follow-up period of 12 months. Conclusion: Limberg’s flap operation is associated with low recurrence as well as a low rate of other complications such as seroma or hematoma formation, wound infection, and persistent pain irrespective of the presentation of the pilonidal sinus.
Twee bewinden tegelijk is soms te veel
Authors: ter Haar J.H.M. 
Published: April 2022

Twee bewinden tegelijk is soms te veel
In de praktijk kan soms een testamentair bewind zijn ingesteld over een verkrijging van een rechthebbende, die zelf vertegenwoordigd wordt door een ouder, voogd, curator of meerderjarigenbewindvoerder. Er is dan sprake van een samenloop van bewind. Deze situatie kan soms ingewikkeld worden als de testamentair bewindvoerder en de ouder, voogd, curator of meerderjarigenbewindvoerder dezelfde persoon zijn. De vraag is dan in hoeverre een testamentair bewind nog gewenst is en welke mogelijkheden er zijn om het testamentair bewind te beëindigen. Mede aan de hand van actuele uitspraken wordt getracht een antwoord op deze vragen te geven.
Feminine Self-Confliction in Asdawun min Alalam Divan (Echoes of Pain) for the Algerian Poet Fatima Alzahraa bin ʿaddu
Authors: Abd alla Mohammed Dr. Elmoukashfi Ibrahim 
Published: April 2022

This study aimed at defining the term of selfness and its association with poetry, then discussing feminine self-confliction in the poetic collection of Asdawun min Alalam as to unveil what the poet had encountered of pains and sufferings as well as her attitudes toward her Arab society during the second half of the twentieth century. Moreover, it aimed at understanding dimensions and nature of conflict between man and women in the East generally. The researcher adopted the descriptive analytical method in this study. The study came to a number of findings, the most important of which are: first, man in Asdawun min Alalam Divan is used as an indication to injustice and selfishness; he deprived woman from her freedom, value and dignity. Then, the reality of the Eastern community confuses between love, friendship, and marriage as well as between attraction and admiration. In addition, the Eastern manly brain is controlled by masculinity and virility, and those brains are - more or less - sex slaves as well as an animal of the modern civilization. Finally, there is an urgent necessity for a revolution that would take down this falling and shaky structure of the dominant masculine heritage.
Historical Computer Science today: "ambiguous understanding"? (contemporary discussions)
Authors: Borodkin Leonid 
Published: April 2022

The article contains a critical analysis of two theses presented in a recently published monograph on historical information systems. The book contains a lot of useful information, including a description of the author's experience in developing such systems. Both theses discussed are related to the authors' assessment of the evolution of an interdisciplinary field focused on the use of information/digital technologies and data analysis methods in historical research. We are talking about historical computer science, which has passed a 30-year path in our country. The first controversial thesis of the authors of the book boils down to the statement that "historical informatics has not found sufficient and deserved recognition among traditional historians." В The first controversial thesis of the authors of the book boils down to the statement that "historical informatics has not found sufficient and deserved recognition among traditional historians." In the second thesis, we are talking about the fact that in many ways the field of research and development, previously related to historical computer science, is now being considered in line with digital history. Both theses are disputed in the article, the corresponding arguments are given. The specificity of the Russian model of historical informatics, which distinguishes it from the relatively recent versions of digital history, is shown. This specificity is determined by the balance of the structure of historical informatics, combining its "resource" component with an analytical one aimed at obtaining meaningful meaningful results (and with an emphasis on the second component).
The Relationship between Drug Adherence to Antiretroviral Therapy and Viral Load in Children Living with HIV
Authors: Sangwan Aditya , Hemal Alok , Dharmaraj Patra G. , Kumar Nitish 
Published: April 2022

Introduction: HIV infection is one of the major public health issues in India and globally. Adherence to ARV drugs is important for optimal virological suppression and should be assessed routinely and strictly reinforced. There is limited information on adherence patterns and its determinants in children in resource-constrained countries because these countries have limited options if viral resistance develops. The objective of our study was to determine the relationship between viral load and drug adherence in children living with HIV and to determine socio-demographic factors affecting adherence and reasons for non-adherence.
Materials and Methods: In this cross-sectional observational study, 70 children on ART were enrolled after applying the inclusion and exclusion criteria. All clinical, demographic details and investigations available were noted. Adherence was assessed by the pill counting method. Caregivers who reported missing doses were given the pediatric nonadherence questionnaire. Blood sample was analyzed for viral load estimation. Appropriate statistical tests were used and analysis was done.
Results: The mean age of diagnosis in study subjects was 8.13 ± 3.89 years and mean duration of treatment was 4.24 ± 3.05 years. Majority, 61(87.1%) patients had adherence more than 95%. Among 9 non-adherent children, the main reason was that they forgot to take medicine in 8(88.9%) cases. The adherent group had significant virological suppression and higher CD4 count. Mean viral load in the adherent group was 2379 ± 5996.74 copies per ml against 46529.22 ± 86633.12 copies per ml in the non-adherent group.
Conclusion: We found that adherent group had a higher CD4 count and a suppressed viral load and adherence to ART was unrelated to age, sex, duration of HIV infection and treatment, socioeconomic status, and route of transmission.
Knowledge, Attitude and Practice of COVID-19 among Health Care Workers of Bhaktapur, Nepal
Authors: Adhikari Kriti , Acharya Aashish , Khanal Sudip , Prasad Sapkota Krishna 
Published: April 2022

Background: To identify the association between different factors associated with knowledge, attitude and practice among the health care workers of Bhaktapur, Nepal.
Materials and Methods: A descriptive cross-sectional study was carried out among 354 Health Care workers of Bhaktapur. The major objective of the study was to evaluate knowledge, attitude and practice of COVID-19 among the health care workers of Bhaktapur, Nepal and direct face to face interview method was carried out for this study. Chi-square test was applied to find the association between various demographic variables and knowledge attitude and practice.
Results: Nearly, three fourth (74.4%) of the male had good knowledge and the female with good knowledge were 47.5%. But the percentage of female with positive attitude (80%) and good practice (67.5) were higher as compared to that of male. There were significant association between gender, years of schooling job description, and family type with the knowledge of the respondents.
Conclusion: The study concluded that female, individuals with the basic and the secondary level of schooling and cleaners/others have a very less good knowledge percentage. Positive attitude among Pharmacists was low as compared to other profession. Similarly, percentage of female with good practice was higher than male and the respondents with years of experience. Among the different measures taken to prevent COVID-19, most of the health care workers said, not touching eyes, nose or mouth without washing hands can prevent COVID-19.Besides this, majority of the respondents said, use of PPE while handling the patients, avoiding close contact with the sick and washing and sanitizing hands also play the crucial role in prevention of spread of the virus.
Thirteen Year Long Term Fertilization Effect on Soil P Balance and Sustainability of a Double Crop of Rice Grown in an Acidic Inceptisol under Sub-Tropical Climatic Situation
Authors: Shivhare Sugyata , Karna Rout Kumbha , Mandal Mitali , Kumar Samant Prasanna , Majhi Pradipta , Phonglosa Amit , Dash Abhiram 
Published: April 2022

The goal of the study was to determine how long-term fertilizer management of a rice-rice production system affected the buildup or depletion of surface soil phosphorus (P) in a subtropical climate. The results showed that using FYM @ 5t ha-1 season-1 in conjunction with optimal NPK doses (80-40-60 kg ha-1season-1) resulted in significantly higher grain yield than using fertilizer alone at optimal, super optimal, or sub-optimal doses or optimal level along with lime/Zn/Zn+B/Zn+S. The use of NPK and FYM together resulted in the highest yield sustainability. Phosphorus balance measured by indirect method (apparent P- balance) and direct method (true P-balance) was positive in all the fertilized treatments and negative in control and 100% N treatment that received no P. High yielding treatments (NPK + FYM or NPK + FYM + Lime) maintained a relatively lower P balance than optimal or super optimal doses because of more removal through higher biomass production. The addition of 50% more phosphorus in 150% NPK treatment caused 9.77% more P accumulation than 100% NPK treatment. Between the two methods, the direct method registered more depletion in the two minus P treatments and less accumulation in all P-treated soils than the indirect method. In soil with a super optimal dose (150% NPK), there is the highest positive balance (25.18 kg ha-1 year-1) as compared to 16.5 kg ha-1year-1in the true method. Seasonal wet and dry grain yield and P uptake poorly correlated with apparent P balance, true P balance and total stock of P. Whereas, sustainability of dry season, wet season and system yield strongly correlated with apparent P balance (r=0.587*, 0.690** and 0.604*), true P balance (r=0.681**, 0.781** and 0.693**) and total stock of P (r=0.680**, 0.780** and 0.692**). Thus true P balance and the total stock of P in surface soil are better indicators of yield sustainability of each season and system as a whole; whereas, available P is closely related to the amount of residual fertilizer P in the soil. Consistent availability of the nutrient depends upon its total stock which in turn depends upon its balance. Knowledge of total stock and nutrient balance is very important for the sustainability of a particular cropping system and evaluating various nutrient management practices for their suitability. Further study on the composition of the total stock of P with respect to various P fractions and their relative contribution to P uptake will be useful for identifying the suitable management practice for P nutrition.
Surgical Management of Chiari 1 Malformation in the Paediatric Population: A Systematic Review and Meta-analyses of Observational Studies
Authors: Taiwo Akhigbe, , Ardalan Zolnourian, 
Published: April 2022

Background: Chiari 1 malformation (C1M) is a congenital malformation in the paediatric population is commonly encountered and often requires surgical management. Currently there is no agreed consensus on the appropriate and specific surgical technique for management of paediatric cases of C1M. The purpose of this systematic review and meta-analysis is to compare the clinical outcomes of posterior fossa decompression with duraplasty (PFDD) to posterior fossa decompression alone (PFD) in paediatric patients.
Methodology: Systematic review of electronic literature databases searched from January 1997 to March 2017 of paediatric patients that had posterior fossa decompression with comparative analysis of PFD and PFDD were considered for inclusion. A Meta-analyses on the retrieved data was performed.
Results: Nine reports of eligible studies involving 3404 patients met the inclusion criteria. Of the 3404 patients, 1965 were treated with PFD alone while 1439 were treated with PFDD. Mean age range of 9.6 year to 11.1 years. Patients undergoing PFDD has significantly higher rates of pseudomeningocele formation OR 1.91, 95% C1 (1.30, 2.82) and lower complication rates OR 1.30, 95% CI (1.06, 1.61) than PFD. No significant difference in clinical improvement, reoperation rates, CSF leaks, wound infection and incidence of aseptic meningitis were observed.
Conclusion: PFDD is associated with fewer complications when compared to PFD alone. However the incidence of pseudomeningocoele formation is more commonly encountered following PFDD compared to PFD. PFDD is also more commonly performed following a failed improvement in symptomatology following PFD. Multicentre randomised controlled studies are needed to definitively identify the gold-standard technique for the management of answer to best surgical technique.
Study of Soluble CD52 as a Tumor Marker and Indicator of Disease Activity in Chronic Lymphocytic Leukemia
Authors: Swadan Fatma ElSaid , Elserogy Hesham Ahmed , Attiaa Mohamed Attia Saad , ElAshtokhy Hussam ElDin Ahmed 
Published: April 2022

Background: Chronic Lymphocytic Leukemia (CLL) is non-curable disease and has variable course among patients. In some patients it progresses fast despite sever treatment and is fatal within 2 to 3 years whereas others require no or minimal treatment and die due to cause other than CLL. The aim of this work was to investigate the circulating soluble CD52 in blood of CLL patients to explore its usefulness as diagnostic and prognostic biomarker.
Methods: This study included 40 cases who were divided into four equal groups; group 1 was patients who were newly diagnosed with CLL, group 2 was cases of chronic lymphocytic leukaemia with complete remission after treatment, group 3 was cases of relapsed chronic lymphocytic leukaemia and group 4 was the control group. All patients were subjected to clinical examinations ,laboratory investigations including: (complete blood counting, liver function tests, kidney function test, LDH Immunophenotyping) and specific laboratory investigation of soluble CD52 using ELISA.
Results: ROC curve for SCD52 to discriminate between newly diagnosed cases and control group with cut of point 201(ng / ml) and AUC 0.890 with p value 0.003 with sensitivity and specificity 80% and to discriminate between relapsed cases from complete remission cases with cutoff point 345 (ng / ml) and AUC 0.840 with (p value 0.010) with sensitivity 80% and specificity 90%. In group 1and group 3, there were positive correlation between SCD52 and staging system, absolute lymphocytic count and LDH, significant negative correlation between SCD52 and platelet count.
Conclusions: The role ofsCD52 as diagnostic and prognostic marker for CLL due to its relation to CLL disease activity.
A Mass Occupied in Neck Carotid Bifurcation Territory Diagnosed Sebaceous Adenocarcinoma: A Case Report
Authors: Jiang Donghui , Wu Xiaoguang , Jia Yanxuan , Ni Shilin , He Xiaoguang 
Published: April 2022

Aims: To describe a rare case presenting with pulsing mass stumbled across the right upper neck.
Presentation of Case: The patient was presented to the outpatient department of ENT due to a pulsing mass stumbled across the right upper neck for half a year. Cervical enhancement CT scan was performed, which disclosed a lesion at the bifurcation of the right carotid artery and possessed insignificant blood supply. Hospitalization was arranged for a full examination, and culminating in a diagnostic resection.
Discussion: This case was challenging for clinicians to differentially diagnose the placeholder at the carotid artery bifurcation, and the pathological results in this case was extremely rare and have never been reported in the literature. Extraocular SGC is strongly associated with Muir–Torre syndrome (MTS), a phenotypic variant of Lynch syndrome and results from mutations in DNA MMR genes. It suggests all patients presenting with sebaceous neoplasms should be screened for MTS.
Conclusion: Our case creates a paradigm for otolaryngologists and oral and maxillofacial surgeons.
18F-FES PET-CT Scan in Patients of Histopathologically Proven Estrogen Receptor Positive Breast Carcinoma at a Tertiary Care Facility
Authors: Adnan Sadia , Younis Muhammad Numair , Yasmin Tahira , Fatima Arzoo , Khan Irfan Ullah , Masood Misbah , Shahid Abubaker 
Published: April 2022

Aims: To ascertain successful labeling and image performance of 18F-FES PET-CT scan in patients who have histopathologically diagnosed estrogen positive breast cancer.
Study Design: Histopathologically proven estrogen receptor positive patients were enrolled for 18F-FES PET-CT scan.
Place and Duration of Study: Department of Nuclear Medicine, Department of Radiopharmacy and Department of Oncology, Institute of Nuclear Medicine and Oncology Lahore- INMOL. Duration of the study including planning phase and performance of imaging was 6 weeks spanning between July till Aug 2021.
Methodology: 18F-FES was produced by direct nucleophilic radio-fluorination of 3-O-methoxymethyl-16,17 O sulfuryl-16-epiestriol followed by acidic hydrolysis at INMOL. After quality control tests, 18F-FES was injected to the patients. At 60 minutes post injection, each patient underwent PET-CT imaging in supine position as per standard protocol given in the published literature. Image interpretation and processing was performed.
Results: Study was performed on 2 patients. The first patient had estrogen receptor positive breast tumour on trucut biopsy and the second patient presented after excision biopsy. The second patient demonstrated skeletal, nodal and pulmonary metastases.18F-FES uptake was observed in the primary tumour as well as in all metastatic sites.
Conclusion: 18F-FES can successfully be labeled and 18-FES PET-CT can be performed in estrogen receptor positive breast cancer patients to take appropriate treatment decisions.
Review on the Development Dilemma and Strategy of Hip-Hop Dance Enter into College Physical Education Curriculum
Authors: Xuanmin Zhu , Qingjian Liu , Qiaoting Hou 
Published: April 2022

Hip-hop dance in colleges and universities is not only the need of physical education curriculum reform, but also an important way for students to improve their character, improve their comprehensive ability and exercise their psychological quality. Based on the research methods of literature and text analysis, it is found that there are four problems: single teaching content and form, lack of clear teaching objectives, lack of training and reward systems, and lack of professional teachers. Accordingly, four countermeasures are put forward: adding Chinese elements into hip-hop teaching, establishing hip-hop teaching objectives, constructing a complete system from teaching to competition, and strengthening the professional skills and cultural literacy of teachers.
Fiducial marker position affects target volume in stereotactic lung irradiation
Authors: Akasaka Hiroaki , Mizonobe Kazufusa , Oki Yuya , Uehara Kazuyuki , Nakayama Masao , Tamura Shuhei , Munetomo Yoshiki , Kawaguchi Haruna , Ishida Jun , Harada Aya , Ishihara Takeaki , Kubota Hikaru , Kawaguchi Hiroki , Sasaki Ryohei , Mayahara Hiroshi 
Published: April 2022

AbstractPurposeReal‐time tracking systems of moving respiratory targets such as CyberKnife, Radixact, or Vero4DRT are an advanced robotic radiotherapy device used to deliver stereotactic body radiotherapy (SBRT). The internal target volume (ITV) of lung tumors is assessed through a fiducial marker fusion using four‐dimensional computed tomography (CT). It is important to minimize the ITV to protect normal lung tissue from exposure to radiation and the associated side effects post SBRT. However, the ITV may alter if there is a change in the position of the fiducial marker with respect to the tumor. This study investigated the relationship between fiducial marker position and the ITV in order to prevent radiation exposure of normal lung tissue, and correct target coverage.Materials and methodsThis study retrospectively reviewed 230 lung cancer patients who received a fiducial marker for SBRT between April 2015 and September 2021. The distance of the fiducial marker to the gross tumor volume (GTV) in the expiratory (dex) and inspiratory (din) CT, and the ratio of the ITV/V(GTVex), were investigated.ResultsUpon comparing each lobe, although there was no significant difference in the ddiff and the ITV/V(GTVex) between all lobes for dex < 10 mm, there was significant difference in the ddiff and the ITV/V(GTVex) between the lower and upper lobes for dex ≥ 10 mm (p < 0.05). Moreover, there was significant difference in the ddiff and the ITV/V(GTVex) between dex ≥10 mm and dex < 10 mm in all lung regions (p < 0.05).ConclusionThe ITV that had no margin from GTVs increased when dex was ≥10 mm for all lung regions (p < 0.05). Furthermore, the increase in ITV tended to be greater in the lower lung lobe. These findings can help decrease the possibility of adverse events post SBRT, and correct target coverage.