bluuebunny/crossref_metadata_2025_split huggingface dataset:
How to make cancer patients have less pain during subcutaneous implantable venous access devices insertion: the effect of buffered lidocaine.
Authors: belaid Imtinene , Kahloul Mohamed , Ferhi Fahmi , Jebali Chawki , Khouaja Hosni , Hafsa Alaa , Tarmiz Khalil , Ahmed Slim Ben , Benjazia Khaled 
Published: March 2022

Abstract
Purpose: Subcutaneous implantable venous access devices are of great importance for the administration of chemotherapy in cancer patients. They are routinely implanted under local anesthesia. However, patients complain of pain during the injection of local anesthesia. Alleviating pain for cancer patients is of high importance. Our aim was to evaluate the effectiveness of sodium bicarbonate-buffered lidocaine with epinephrine on reducing pain and patients’ satisfaction during subcutaneous implantable venous access devices insertion.Methods: A prospective double-blind study was conducted over a period of 6 months (January 2017 to June 2017) in a department of anesthesiology in Tunisia. Cancer patients were randomized to receive either buffered (PH= 7.33) or plane lidocaine (PH= 3.50). Pain and satisfaction were evaluated on a VAS score (0-100 mm). Results: One hundred twenty patients were enrolled in this study with sixty patients in each group. Mean pain scores during local anesthesia infiltration were 15.7 ± 7.6 mm vs.46.9 ± 12.3 mm respectively in the study and control group (p<0.001). Mean VAS satisfaction was 95.75±8 mm in the intervention group and 70.2±20.1 mm in the control group (p<0.001). Conclusion: Adjusting the pH of anesthetic agents could minimize pain during PortACath insertion and improve satisfaction of cancer patients.
Efficacy and safety of pomalidomide and low-dose dexamethasone in Chinese patients with relapsed or refractory multiple myeloma: a multicenter, prospective, single-arm, phase 2 trial
Authors: Lu Jin , Fu Wei-Jun , Wang Ya-Fei , Zhao Hong-Guo , Niu Ting , Fang Bai-Jun , Liao Ai-Jun , Bai Hai 
Published: March 2022

Abstract
Background: Pomalidomide in combination with dexamethasone has demonstrated positive results in patients with relapsed or refractory multiple myeloma (RRMM), but no data are available in China. We conducted a multicenter, single-arm trial to examine the efficacy and safety of a generic pomalidomide in combination with low-dose dexamethasone in Chinese RRMM patients. Methods: Adult (≥18 years of age) RRMM patients who progressed after at least two previous treatments, including bortezomib and lenalidomide, were eligible. Pomalidomide was given orally at 4 mg/day on days 1 to 21 of the 28-day cycle. Dexamethasone was given at 40 mg/day (either orally or intravenously; 20 mg/day at 75 years or older) on days 1, 8, 15, and 22 of each cycle. Treatment continued until disease progression or intolerable adverse events (AEs). The primary endpoint was objective response rate (ORR). Results: A total of 74 patients were enrolled between February 2017 and February 2019. All patients had progressed within 60 days of their last therapy. 74.3% of the patients were resistant to lenalidomide, 31.1% had renal injury and 33.8% had high-risk cytogenetic RRMM. The median follow-up was 33.0 months (range, 31.1-34.8). The ORR was 37.8% in the overall analysis, 32.7% in lenalidomide-refractory patients, 36.0% in high cytogenetic risk patients and 34.8% in RRMM patients with renal impairment. The median progression-free survival was 5.7 months (95%CI 3.7, 8.8) . The median overall survival was 24.3 months (95%CI 14.4, 41.1) . The most common grade 3 and 4 treatment-emergent adverse events (TEAEs) were neutropenia (63.5%), leukopenia (37.8%), thrombocytopenia (28.4%), and anemia (31.1%). Pulmonary infection (27.0%) was the most frequent grade 3 and 4 nonhematologic TEAE. No previously unreported AEs were observed. No venous thromboembolism was reported.Conclusions: Pomalidomide in combination with low-dose dexamethasone is effective and safe in Chinese RRMM patients.Trial registration: The study is registered at Chinese Clinical Trial Registry (ChiCTR) (ChiCTR-OIC-17013234, first registered on 03/11/2017).
Studying the Formation of Choline Chloride and Glucose Based Natural Deep Eutectic Solvent at the Molecular Level
Authors: Aldongarov Anuar , Sailau Zhassulan , Almassov Nurlan , Toshtay Kainaubek 
Published: March 2022

Abstract
In our work, we have studied the formation of choline chloride based NADESs using DFT calculations, and all-atom classical Molecular Dynamics (MD) simulations. In our DFT calculations, the ground state geometry optimizations were performed in the gas phase using DFT B3LYP 6-31+G(d) level of theory. Moreover, all-atom classical Molecular Dynamics simulations were implemented using Gromos force field. The DFT calculation results revealed the formation of NADESs via formation (creation) of binding between chlorine and choline, and chlorine and glucose. Next, the results of all-atom classical Molecular Dynamics simulations, based on the time average of the equilibrated production run of MD simulations, stated that the nitrogen atom of choline ion, and chloride ion have greater interactions, while chloride ion have also greater interaction with glucose during formation of NADES.
Metabolomics Analysis of the Effects of Chelerythrine on Ustilaginoidea virens
Authors: Wei Qinghui , Song Weifeng , Li Zhiyong , Pan Yaqing , Zhai Xihai , Li Baoying , Jiao Zhanli 
Published: March 2022

Abstract
Background: Rice false smut (RFS), caused by Ustilaginoidea virens, is widely distributed in major rice-producing regions. Previous studies showed that treating RFS with chelerythrine can decrease fungus spore germination by 86.7% and induce fungal cell apoptosis. Result: In the present study, the effects of chelerythrine on the metabolism of U. virens were explored using metabolomics, and analysing differentially expressed genes and altered metabolic pathways. A total of 1153 features (740 in positive ion mode, 401 upregulated, 339 downregulated; 413 in negative ionisation mode, 190 upregulated, 223 downregulated). The top 15 metabolites in Random Forest analysis were significantly different between groups. In positive ion mode, purine metabolism (map00230), phenylalanine metabolism (map00360), phenylalanine, tyrosine and tryptophan biosynthesis (map00400), pyrimidine metabolism (map00240) and nitrogen metabolism (map00910) were dominant. Alanine, aspartate and glutamate metabolism (map00250) and phenylalanine metabolism (map00360) were enriched in negative ion mode. Conclusion: Differentially expressed genes and altered metabolic pathways of U. virens were effected by chelerythrine. The findings support future research on the prevention and treatment of RFS by chelerythrine, and provide a theoretical basis for targeted drug delivery.
Biomass composting combined with dicyandiamide influence greenhouse gas emission and microbial community in rice paddy
Authors: Lantian Ren , Thertully Clevie , Wang Yachun , Huang Xingchen , Min Hongzhi , Zou Yuning , Hao Bing , Ren Lantian , Qiao Cece 
Published: March 2022

Abstract
Characterizing the rhizosphere microbial community composition associated with enhanced crop yield and (or) greenhouse gases is an important first step towards understanding the role of the microbiota in rice paddies. This research aimed to decipher the influence of straw tea composting product combined with dicyandiamide amendment on greenhouse gas emission and microbial community in rice paddies.The results indicated that amendment of biological nitrification inhibitors can mitigate gas emissions and significantly increase rice yield by 41.70%, and improve the growth and development of the root system. Furthermore, composting product can mitigate greenhouse gas emissions, and bionitrification inhibitor combined with straw compost tea can effectively increase the growth and development of rice, the number of panicles, which are respectively 9.75% and 18.34%. However, the biological nitrification inhibitor impacted the communities of nitrogen-fixing bacteria (Proteobacteria), bacteria capable of eliminating nitrogen (Nitrospirae) as well as Verrucomicrobia known to be one of the most common and diverse phyla in soil habitats. As with bacteria, a distinct community structure and distribution patterns for archaea were observed in soils; however, the abundance, richness, regularity and diversity of archaea communities were significantly less in the different samples. In addition, biological nitrification inhibitors have had an impact in Euryarchaeota, responsible for the elimination of methane.
The Frequency of Positive Cases of Fecal Calprotectin, and Related Factors in Patients with Systemic Sclerosis
Authors: Fatemi Alireza , Zahedpasha Reza , Hedayatmofidi Hale , Abdolahi Nafiseh , Hadi Gharib , Livani Somayeh , Aghaie Mehrdad 
Published: March 2022

Abstract
Background and aim: SSc (Systemic sclerosis) is a systemic inflammatory heterogeneous disease, characterized by fibrosis of skin and internal organs particularly the gastrointestinal tract by affecting any part of it. Calprotectin is a calcium- and zinc-binding protein and its level increases during an inflammatory process in the presence of neutrophils, measurable in plasma, urine, saliva, and feces. FC (Fecal calprotectin) is a non-invasive and repeatable marker for the diagnosis of intestinal inflammation and unlike other inflammatory markers, the FC level is not affected by other sources of inflammation other than intestines. The quality of life in SSc patients is severely affected by gastrointestinal disorders. So, we decided to examine FC as a simple and accessible method with no complication to diagnose gastrointestinal disorders and the extent of disease activity.Materials and methods: Totally 46 patients with SSc were invited to include in our study. Seven patients did not enter our study because of having the items in exclusion criteria. For the remaining 39 patients, a questionnaire about gastrointestinal disorders symptoms (UCLA SCTS 2.0) was filled in and then their skin was examined and the skin score was determined. Stool samples were collected to measure the calprotectin level. Barium Swallow and CT Enterography was done to determine gastrointestinal disorders. FC level wasn’t less than 50µgr/gr in any of our cases, therefore the patients was divided into two groups: the one with FC level less than 200 µgr/gr and the one with FC level as 200 µgr/gr or more than 200 µgr/gr and the latter was considered as positive. Chi-Square test was used and to determine the correlation between FC level and age, disease type, qualitative findings in radiography and quantitative variables like skin score.Results: The correlation between FC level and sex was not verifiable cause all patients were female. Increased levels of FC didn’t have any correlation with age (P Value=0.79), disease type (P Value=0.59), skin score (P Value=0.25), final GI score (P Value=0.30), esophageal dilatation (P Value=0.18), small intestine wall thickening (P Value=0.10), and none of serum tests. Also, no signs of micronutrient deficiencies related to FC level was found due to vitamin and mineral supplements consumption in most of our patients.Discussion and Conclusion: Although there was no statistical correlation between FC level and variables, but the results are in favor of FC specificity to assess intestinal wall thickness, which due to the small sample size requires to be assessed in future researchers’ study with a larger sample size.The main cause of the lack of statistical significance in the relationships of our study can be the low sample size. Therefore, it is recommended that in future researchers’ study with a larger sample size.
New Correlation for the CHTC of Building Surface Using Wind-Tunnel Measurement and Numerical Analysis
Authors: Fakhim Hamed Agabalaei , Zamzamian Kamiar , Hanifi Masoud 
Published: March 2022

Abstract
This paper has been attempted to present a relation for CHTC based on effective parameters using numerical modeling and simulations, laboratory work, and mathematical analysis. Firstly, the experimental model in numerical analysis software was simulated and the results were compared with laboratory results. The influence of different parameters such as wind speed, wind angle, temperature difference, and roughness height on the CHTC of the top and windward faces of the building were investigated. Comparison of the effect of the parameters showed that for both the front and top of the cubic plane, the wind velocity and temperature difference had the highest and lowest effects on the upper and front faces, respectively. It was also found that in the front face, the angle effect was greater than the roughness, whereas in the upper face the roughness height had more influence on the CHTC. Finally, for the obtained results and considering the amount, two relational methods have been derived to calculate CHTC for the top and front face. Also, using the analyzed results, the neural network design was performed. it was found that using this neural network, the CHTC of building surfaces can be calculated with high accuracy.
Adaptive Amino Acid Substitutions Enhance the Virulence of a Novel Swine-Origin Canine H1N1 Influenza Virus in Mice
Authors: Zeng Hao , He Jianqiao , Zhu Min , Liu Linlin , Guo Jinfan , Guo Jianing , Zhou Huabo , Wei Zuzhang , Ouyang Kang , Huang Weijian , Chen Ying 
Published: March 2022

Abstract
Swine-origin H1N1 influenza virus caused an outbreak in human in 2009 (H1N1/pdm09). We isolated several novel reassortant influenza A viruses bearing the H1N1/pdm09 segments (PB2, PB1, PA and NP) from dogs, which showed high similarity with H1N1 swine influenza virus in the previous study. To understand the molecular basis of swine-origin H1N1 reassortant canine influenza virus adaptation to new host species, the mouse-adapted variants of H1N1 canine virus were obtained by serial lung-to-lung passages in BALB/c mice. After thirteen passages, the virus significantly enhanced replication in MDCK cells and became lethal to mice. Six adaptive mutations mapped to two in the ribonucleoprotein (RNP) complex (PB2-E578D, PA-T97I), two in hemagglutinin (HA-N198D and A227E), two in the non-structural protein 1 and nuclear export protein (NS1-A53D and NEP-R42K), indicating that they may contribute to the increased virulence and replication. The results provided valuable insights into how the swine-origin influenza virus adapt to a new host that deserves more attentions.
Incidence and Risk Factors of Infusion Reactions in Breast Cancer Patients Administered Pertuzumab Combination Chemotherapy
Authors: Tabuchi Yusuke , Tsujimoto Masayuki , Yamamoto Kosuke , Kosaka Tadashi , Sakaguchi Koichi , Dobuchi Naoya , Nishiguchi Kohshi , Shikata Keisuke 
Published: March 2022

Abstract
Purpose: Pertuzumab (Per) is a humanized monoclonal antibody used in combination with trastuzumab (Tra) in the treatment of human epidermal growth factor receptor-2 (HER2)-positive breast cancer. The administration of biologics, such as Tra and Per, frequently causes infusion reactions (IRs) with fever and chills. The purpose of this study was to clarify the characteristics of and risk factors for IRs in Tra+Per combination therapy.Methods: Between March 2013 and December 2019, 65 breast cancer patients who started Tra+Per combination therapy and 106 breast cancer patients who started Tra therapy alone were included in the study. The severity of IRs was graded according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.Results: The incidence of IRs in the Tra+Per group was 47.7% (31/65) and was significantly higher than that in the Tra alone group (18.9%, 20/106), with a risk ratio of 2.53 (p < 0.001). The severity of IRs in the Tra+Per group (Grade 1, 9 patients; Grade 2, 22 patients) was significantly higher than that in the Tra alone group (grade 1, 16 patients; grade 2, 4 patients) (p < 0.001). Lymphocyte counts were significantly different between the IR and non-IR groups in patients receiving Tra+Per combination therapy (univariate analysis, p = 0.005; multivariate analysis, p = 0.029).Conclusion: Our study indicates that the concomitant use of Per increases the risk of IRs caused by Tra, and the risk of IRs is higher in patients with higher lymphocyte counts.
A Reconfigurable Smart Antenna Beamforming Architecture for Secure Localization Applications
Authors: Biswas Rathindra Nath , Saha Anurup , Mitra Swarup Kumar , Naskar Mrinal Kanti 
Published: March 2022

Abstract
Beamforming of an adaptive array antenna often becomes effective for the precise localization of nodes in wireless sensor networks. In an erratic channel, a link with possibly a narrower beamwidth is always suitable for sending data to target nodes. It can also cancel interference from other nearby nodes while steering deep nulls and keeping the lower sidelobe level in the pattern. This paper presents a custom design for such a beamforming network on a reconfigurable architecture. It includes all the desired attributes of the beam on a reference template characterized by the parabolic function. It also considers a linear array with non-uniform element excitations. Using the Particle Swarm Optimization (PSO) algorithm, the weight vector containing the excitations of the array elements is iteratively optimized. It is then implemented adopting the concept of the Finite State Machine with Datapath (FSMD) model and using appropriate COordinate Rotation DIgital Computer (CORDIC) blocks. Its performance is tested on a dedicated Field Programmable Gate Array (FPGA) board with multiple fixed-point hardware-level simulations for beamforming accuracy and computational overhead. The results corroborate its competence comparable to existing systems.
The Transcription Factor LaMYC4 From Lavender Regulates Terpenoid Biosynthesis
Authors: Dong Yanmei , Zhang Wenying , Li Jingrui , Wang Di , Bai Hongtong , Li Hui , Shi Lei 
Published: March 2022

Abstract
Background
The basic helix-loop-helix (bHLH) transcription factors (TFs), as one of the largest families of TFs, are important regulators of plant terpenoid biosynthesis and response to stresses. Lavender has more than 75 volatile terpenoids, yet few TFs have been identifified to be involved in the terpenoid biosynthesis.
Results
Based on RNA-Seq, reverse transcription-quantitative polymerase chain reaction, and transgenic technology, this study characterized the stress-responsive transcription factor LaMYC4 regulates terpenoid biosynthesis. Treatment with methyl jasmonate (MeJA) increased volatile terpenoid emission, and the differentially expressed gene LaMYC4 was isolated. LaMYC4 expression level was higher in leaves than in other tissues. The expression of LaMYC4 decreased during flower development. The promoter of LaMYC4 contained hormone and stress-responsive regulatory elements and was responsive to various treatments, including UV, MeJA treatment, drought, low temperature, Pseudomonas syringae infection, and NaCl treatment. LaMYC4 overexpression increased the levels of sesquiterpenes, including caryophyllenes, in Arabidopsis and tobacco plants. Furthermore, the expression of key node genes involved in terpenoid biosynthesis and glandular trichome number and size increased in transgenic tobacco.
Conclusions
we have shown that the stress-responsive MYC TF LaMYC4 from ‘Jingxun 2’ lavender regulates terpenoid synthesis. This study is the first to describe the cloning of LaMYC4, and the results help understand the role of LaMYC4 in terpenoid biosynthesis.
One-step synthesis of rod-on-plate like 1D/2D-NiMoO4/BiOI nanocomposite for an efficient visible light driven photocatalyst for pollutant degradation
Authors: Bavani Thirugnanam , Vinesh Vasudevan , Neppolian Bernaurdshaw , Murugesan Sepperumal , Selvaraj Manickam , Madhavan Jagannathan 
Published: March 2022

Abstract
A visible light driven 1D/2D-NiMoO4/BiOI nanocomposite photocatalyst was constructed by single step solvothermal method. Here, various composition of NiMoO4/BiOI nanocomposites were prepared by loading different amounts of NiMoO4 (1, 2, 3 wt %) to the BiOI. Among the as-prepared photocatalysts, 1 wt % of NiMoO4 on BiOI (NMBI-1) showed superior photocatalytic activity (92.7 %) under visible light irradiation. On analysis, the optimized NMBI-1 exhibited a lower bandgap energy value of 1.64 eV and also found to show around 2 and 3.7-times higher degradation ability for the removal of MB than the pure NiMoO4 and BiOI respectively. In addition, the optimized NMBI-1 nanocomposite photocatalyst exhibited excellent photostability and recyclability properties. The charge carriers on the interface of the NiMoO4 and BiOI enabled the easy transfer via the newly formed heterojunction, thereby increasing the photocatalytic performance. Additionally, the radical scavengers such as h+ and .OH were found to be the major species in the removal of MB under visible light illumination. Therefore, the 1D/2D-NiMoO4/BiOI nanocomposite photocatalyst materials could possibly be considered for the wastewater remediation processes.
Potential anti-inflammatory effects of Pingyin Rose Essential Oil on Lipopolysaccharide-induced HaCaT Cells
Authors: Song Jingyi , Raka Rifat Nowshin , Yuan Yue , Park Suyeon , Wang Juan , Liu Fei , Wu Hua , Xiao Junsong , Huang Mingquan , Yang Suzhen 
Published: March 2022

Abstract
Background: Skin is the primary defense to human body from external exposure of harmful stimulation. Excessive and improper immune-regulation could cause chronic inflammation resulting in different skin diseases. Pingyin Rose is a well-known component of traditional Chinese medicine (TCM) because of its wide range of bioactivities and so do PREO.Aim: The present work aims to characterize the Pingyin rose essential oil (PREO) composition, investigate the beneficial effects of PREO on the skin inflammation in vitro and determine ligands for OR2AT4 in silico from PREO components.Materials and Methods: PREO was quantified by GC-MS and molecular docking was performed for OR2AT4 with top two components. HaCaT cells were induced with lipopolysaccharides (LPS) to study downregulation of oxidative stress and inflammation through NF-κB signaling. Result and Discussion: According to our results, Citronellal (54.28%) and geraniol (9.26%) are the principal compounds of PREO and both deemed to be potential ligand for OR2AT4. PREO could significantly reduce the expression of the TLR4-NF-κB pathway in LPS-induced HaCaT cells. PREO could also prevent LPS-mediated oxidative stress, including the increase of SOD and MDA, decrease of mRNA expression for inflammatory markers (TNF-α, IL-1β, IL-6, IL-8) and several genes involved in TLR4 pathway, that is also an evident for PREO as potential anti-inflammatory therapeutic. PREO also inhibits NF-κB p65 and IκB-α protein phosphorylation. Conclusion: Our findings revealed that PREO could decrease inflammatory protein expressions, possibly functioning with the reduction of oxidative stress and inflammatory cytokines via downregulating NF-κB pathway. PREO component can interact with OR2AT4 and paly roles in other physiological activities.