bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling and identification of affective parameters on cadmium’s durability and evaluating cadmium pollution indicators caused by using chemical fertilizers in long-term
Authors: Rahimi Meisam , Kamyab Taraneh , Rahimi Ghasem , Chatraei Ehsan , Naimi Salman , Ebrahimi Eisa 
Published: July 2022

Abstract
Soil contamination by anthropogenic heavy metals has become a global issue. This study aimed to investigate Cadmium (Cd) concentration, the mobility, and contamination indices of Cd in soils in the Hamadan province, west of Iran. One hundred soil samples from wheat farms and five samples from control lands were collected to investigate the Cd concentration in soil. Pollution indexes, including Cd mobility, enrichment factor (EF), geoaccumulation index (Igeo), contamination index (CI), and Availability ratio (AR), were investigated. The structural equation model was also used to evaluate effective parameters on cadmium’s durability in soil. Results showed that mean values of available phosphorus (P) were 83.65, 129, and 65 (mg kg− 1) in three land-use types rainfed, irrigated, and controlled, respectively. The mean values of available Cd were 0.15, 0.18, and 0.08 (mg kg− 1) in different land-use types of rainfed, irrigated, and controlled, respectively. The results indicated that the amount of Cd in both forms (available and total) in farms that received fertilizer, especially P fertilizers, was higher than in the controlled land. Other pollution indexes revealed that the study area had been slightly contaminated due to anthropogenic activities. Lime, clay, lead, and OM were identified as affective parameters on the durability of cadmium. Finally, the results demonstrated that the mobility rate was high. Cd had a higher mobility potential in soil samples in the rain-fed and irrigated land than in the controlled land, and Cd had a low retention time.
A polynomial model of transmission and reflection of electromagnetic monochromatic plane waves in lossy, non-magnetic multilayer thin films subjected to an external transverse voltage
Authors: Elhabbash Mohammed K. M. , Halim Mohd Mahadi , Yoon Tiem Leong , Taya Sofyan A. 
Published: July 2022

Abstract
Simulation of the electrical and optical response of a multilayer thin film composed of lossless material coupled with adjacent lossy material in an alternating arrangement when applying a transverse voltage across the multilayer thin film is conducted using a polynomial approach. The modelling of the lossy-lossless multilayer thin film is a generalization of our previous work on multilayer thin film made up of alternating lossy-lossy materials. It is the propagation matrix of the electromagnetic wave in the thin film that governs its propagation, while the interface matrix represents the coupling between layers at an interface. The present solution models the multilayer thin film as an effective capacitor constructed from a series of coupled capacitors, with every layer being considered as a capacitor coupled to the next. A transverse voltage can affect the amounts of electric charges that accumulate at the interface between adjacent ‘capacitors’. The present model is constructed to describe nonmagnetic, lossy and lossless materials. With the aid of a home-developed code implementing the model, reflection and transmission of multilayer Ge/MgO thin films are simulated. By tuning the transverse electric potential, geometrical and electrical parameters of an arbitrary lossy-lossless multilayer thin film, the code is capable of predicting nontrivial optical responses in terms of 𝑇(𝜆),𝑅(𝜆),𝜙𝑇(𝜆),𝜙𝑅(𝜆). The code can serve as a useful tool for designing and optimizing lossless-lossy or lossless-lossless multilayer thin films to deliver desired optical functions.
Slow negative feedback enhances robustness of square-wave bursting
Authors: John Sushmita Rose , Krauskopf Bernd , Osinga Hinke M. , Rubin Jonathan E. 
Published: July 2022

Abstract
Square-wave bursting is an activity pattern common to a variety of neuronal and endocrine cell models that has been linked to central pattern generation for respiration and other physiological functions. Many of the reduced mathematical models that exhibit square-wave bursting yield transitions to an alternative pseudo-plateau bursting pattern with small parameter changes. This susceptibility to activity change could represent a problematic feature in settings where the release events triggered by spike production are necessary for function. In this work, we analyze how model burst patterns vary with changes in the conductance of a fast inward current. Using numerical simulations and dynamical systems methods, such as fast-slow decomposition and bifurcation and phase-plane analysis, we demonstrate and explain how the presence of a slow negative feedback associated with a gradual reduction of a fast inward current in these models helps to maintain the presence of spikes within the active phases of bursts. Therefore, although such a negative feedback is not necessary for burst production, we find that its presence generates a robustness that may be important for function.
Influence of well-being and quality of work-life on quality of care among health professionals in Southwest, Nigeria
Authors: Odole Adesola C. , Ogunlana Michael O. , Odunaiya Nse A. , Oyewole Olufemi O. , Mbada Chidozie E. , Onyeso Ogochukwu K. , Ayodeji Ayomikun F. , Adegoke Opeyemi M. , Odole Iyanuoluwa , Sanuade Comfort T. , Odole Moyosooreoluwa E. , Awosoga Oluwagbohunmi A. 
Published: July 2022

Abstract
The Nigerian healthcare industry is bedevilled with infrastructural dilapidations, inadequate funding and staffing, and a dysfunctional healthcare system. This study investigated the influence of health professionals’ well-being and quality of work-life (QoWL) on the quality of care (QoC) of patients in Nigeria. The study was a multicentre cross-sectional survey conducted at four tertiary health institutions in southwest, Nigeria. Participants’ demographic information, well-being, quality of work-life, and quality of care were obtained using four standardized questionnaires. Data were summarized using descriptive statistics of frequency (percentage) and mean (standard deviation). Inferential statistics included Chi-square, Pearson’s correlation, and independent samples t-test analyses. Medical practitioners (n = 609) and nurses (n = 570) constituted 74.6% of all the health professionals with physiotherapists, pharmacists, and medical laboratory scientists constituting 25.4%. The mean (SD) participants’ well-being = 71.65% (14.65), quality of life = 61.8% (21.31), quality of work-life = 65.73% (10.52) and quality of care = 70.14% (12.77). Participants’ quality of life had a significant negative correlation with quality of care while well-being and quality of work-life had a significant positive correlation with quality of care. We concluded that health professionals’ well-being and quality of work-life are important factors that influence their productivity and ultimately the quality of care rendered to patients. The hospital management and policymakers should ensure improved work-related factors to promote the well-being of health professionals, in order to enhance the quality of care given to patients and ultimately reduce brain drain and medical tourism.
Incidence and risk of pancreatic cancer in patients with chronic pancreatitis: defining the optimal subgroup for surveillance
Authors: Kim Hyo Suk , Gweon Tae‒Geun , Park Sang Hi , Kim Tae Ho , Kim Chang Whan , Chang Jae Hyuck 
Published: July 2022

Abstract
We aimed to present the incidence and risk factors for pancreatic cancer in a multicenter retrospective cohort of patients with chronic pancreatitis (CP). Patients with ICD‒10 codes for CP (K86.0, K86.1) who underwent abdominal CT or MRI between January 2010 and December 2021 in seven academic hospitals were analyzed. After exclusions, we identified 727 patients with definite CP with a median follow‒up of 3.6 years (range 1.0‒12.9). During 3,290 person‒years of observation, pancreatic cancers were diagnosed in 16 patients (2.20%, 0.49% per year) after a median follow‒up of 2.4 years (range 1.4‒6.6), with an age‒ and sex‒standardized incidence ratio of 18.1 (95% CI 10.4‒29.5). The underlying CPs in the 16 pancreatic cancers were classified as chronic obstructive pancreatitis (10, 63%), chronic obstructive and calcifying pancreatitis (4, 25%), chronic calcifying pancreatitis (1, 6%), and autoimmune pancreatitis (1, 6%). Factors associated with pancreatic cancer development included age (HR 4.830, p = 0.006), parenchymal calcification (HR 0.213, p = 0.003), pancreatic duct stricture (HR 2.706, p = 0.048), and serum CA 19‒9 level (HR 22.49, p < 0.001). After adjustment, age greater 60 years (HR 5.580, p = 0.007) and serum CA 19‒9 levels greater 100 U/mL (HR 25.56, p < 0.001) were independent risk factors for pancreatic cancer.
Construction and experimental validation of ferroptosis-related competing endogenous RNA networks in hepatocellular carcinoma based on WGCNA
Authors: Guo Ting , He Kun , Chen Weigang , Xu Mengwei , Sun Jingjing , Chen Yong , Yang Zelong 
Published: July 2022

Abstract
The ferroptosis-related competing endogenous RNAs (ceRNA) network in hepatocellular carcinoma (HCC) has not been fully explored. In this study, RNA sequence data of HCC and clinic data were downloaded from The Cancer Genome Atlas (TCGA) database. Through the pre-set three gene sets of autophagy, pyroptosis, and ferroptosis, each sample was scored by single-sample Gene Set Enrichment Analysis (ssGSEA), and ferroptosis was associated with overall survival. We used Weighted Gene Co-Expression Network Analysis (WGCNA) analysis to modularize long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA). The most ferroptosis related modules were identified by correlation analysis. Enrichment analysis showed the genes were significantly enriched in ferroptosis-related functions and pathways. The ceRNA network was constructed by the prediction from online tools. We randomly selected one axis for laboratory verification, the DNAJC27-AS1/miR-23b-3p/PPIF axis. Functionally, DNAJC27-AS1 and PPIF could negatively regulate the level of ferroptosis in HCC cells, while miR-23b-3p played positively. Mechanistically, miR-23b-3p can directly bind to DNAJC27-AS1 and PPIF, respectively. DNAJC27-AS1 and PPIF can regulate mutually through sponging miR-23b-3p and act as potential ferroptosis regulators. Taken together, we provided a reliable ferroptosis-related ceRNA network and preliminarily verified it. This study may offer new insights for future research on ferroptosis in HCC.
PHM6 and PHM7 Genes are Essential for Phosphate Surplus in the Cells of Saccharomyces cerevisiae
Authors: Kulakovskaya Ekaterina , Kulakovskaya Tatiana 
Published: July 2022

Abstract
Phosphate transport and accumulation of phosphorus reserves are necessary for the adaptation of microorganisms to adverse environment. The yeast Saccharomyces cerevisiae is capable of luxury phosphate uptake and polyphosphate (polyP) accumulation when the cells were placed to phosphate sufficient medium after phosphorus starvation (phosphate surplus conditions). We have studied the effect of knockout mutations in the genes encoding phosphate transporters and two PHO pathway membrane proteins of unknown function, Phm6 and Phm7, on phosphate uptake and polyP accumulation. Single knockout mutations in the PHO84, PHO87, PHO89, PHM6, and PHM7 genes suppress the phosphate uptake and polyP accumulation under phosphate surplus conditions in the presence of glucose and phosphate with or without Mg2+. A knockout mutation in the vacuolar membrane phosphate transporter gene PHO91 slightly reduced phosphate uptake and increased polyP accumulation. A knockout mutation in the PHO90 gene suppressed phosphate transport and polyP accumulation in the absence of Mg2+, while phosphate transport and polyP accumulation in the presence of Mg2+were similar to those of the parental strain. The knockout strains in the PHM6 and PHM7 have decreased polyP accumulation when growing under Pi surplus conditions in the full YPD medium. The PHM6 or PHM7 genes are essential for enhanced Pi uptake and polyP accumulation under phosphate surplus conditions. We speculate that plasma membrane Pi transporters Pho84, Pho87 and Pho89 work in concert, and Phm6 and Phm7 proteins participate in the interaction of these phosphate transporters under phosphate surplus, providing luxury phosphate uptake at phosphate surplus conditions.
Numerical investigation on seismic dynamic response characteristics of high-steep layered granite slopes via time-frequency analysis
Authors: Shi Wanpeng , Zhang Jianwei , Song Danqing , Guo Zizheng , Tang Gaojie , Han Dechao 
Published: July 2022

Abstract
The occurrence of geological structure and stratum lithology plays important roles in the seismic stability of complex slopes, which is also the difficult points of engineering construction. Four three-dimensional layered granite slope models with infinite boundary were modeling via finite element method (FEM). Seismic response and deformation characteristics of slopes are systematically studied through time-frequency domain. A frequency-domain analysis method of complex slopes is proposed including modal and spectrum conjoint analysis. Modal analysis can directly display the main vibration modes of slopes. The combination of modal and spectral analysis can clarify the inherent characteristics of slopes, and reveal the interaction mechanism between inherent frequency and dynamic characteristics of slopes. The results illustrate that structural faces have significant effects on the propagation characteristics of wave within rock mass, and complex refraction/reflection phenomena occur near these discontinuities, thus to different dynamic response characteristics in the slope. Layered slopes have apparent magnification effect of slope surface and altitude. Directions of seismic excitation and structural plane types affect the dynamic response of slopes. Horizontal wave mainly affects the middle and upper part of high-steep slope, while vertical wave has obvious influence on the slope crest. Additionally, Fourier spectral analysis shows that structural planes have filtering effects on the high-frequency waves. Combined with modal analysis, it further explains that high-frequency section of waves mainly triggers local deformation of slopes, while low-frequency component controls their overall deformation. Finally, instability regions and evolution process of different layered slopes were predicted based on time-frequency conjoint analysis.
Association Between Hematological Parameters and Generalized Severe Periodontitis Among Young Adults in the United States
Authors: Hu Menglin , Zhang Wenhao , Shi Zhimin , Dai Bichong , Liu Xiaoyun , Cheng Xu , Zhang Hengguo , Wang Yuanyin 
Published: July 2022

Abstract
Background: Generalized severe periodontitis (GSP), a common oral inflammatory disease associated with systemic circulatory disease, can result in tooth loss and chewing dysfunction. Objective: This study aims to investigate the relationship between GSP and systemic circulation-related hematological parameters in young adults aged 30 to 40.Methods: A total of 212 participants were enrolled in the National Health and Nutrition Examination Surveys (NHANES) during 2009 to 2014. The generalized severe periodontitis was identified as 30% of teeth with ≥ 5mm attachment loss. Restricted cubic splines were used to investigate the nonlinearity among variables. Logistic regression analysis was utilized to study the hematological parameters correlated with GSP. Stepwise regression and receiver operating characteristic curve were applied to generate and assess the predictive models for GSP occurrence. Results: Based on the indicators of 212 subjects, we found that generalized severe periodontitis tended to occur in males and was accompanied by higher Hemoglobin (HB), Hematocrit (HCT), Red cell distribution width (RDW), Red blood cell count (RBC), as well as less Poverty-income ratio (PIR). Restricted cubic splines confirmed the relationships between GSP and HB or HCT were nonlinear. Logistic regression showed that RDW was a potential indicator of GSP. Compared with HCT (AUC = 0.702), HB (AUC = 0.697), RBC (AUC = 0.684), RDW (AUC = 0.585), and other single variable, multi-variables regression (including gender, PIR, RDW, education levels, and BMI) (AUC = 0.913) demonstrated better predictive effects on generalized severe periodontitis.Conclusion: Hematological parameters can predict generalized severe periodontitis, for which RDW is a potential indicator.
COL1A1 and COL3A1 elevation and regulation by β2-microglobulin in subsynovial connective tissues of patients undergoing hemodialysis with carpal tunnel syndrome
Authors: Muneshige Kyoko , Onuma Kenji , Yokozeki Yuji , Sukegawa Koji , Otake Yuya , Metoki Yukie , Nakawaki Mitsufumi , Itakura Makoto , Inoue Gen , Takaso Masashi , Uchida Kentaro 
Published: July 2022

Abstract
Purpose: Carpal tunnel syndrome (CTS) constitutes a typical complication of patients receiving long-term hemodialysis (HD). However, the mechanisms underlying the manifestation of CTS in patients receiving long-term hemodialysis remain to be studied. We investigated collagen gene expression in the subsynovial connective tissue (SSCT) of patients undergoing hemodialysis and evaluated the effect of β2-microglobulin (B2M) on collagen gene expression in cells derived from the SSCT.Methods: To study the expression of collagen genes in the SSCT of HD and non-HD patients, SSCT specimens were obtained from 64 patients with CTS (47 non-HD and 17 HD) during carpal tunnel release (CTR). To evaluate the fibrotic condition of SSCTs, COL1A1 and COL3A1 expression were evaluated using qPCR. To evaluate the effect of B2M on collage genes, SSCT cells were stimulated in α-MEM with 0.5% fetal bovine (vehicle) or 1 or 10 µg/ml B2M.Results: Expressions of both COL1A1 and COL3A1 in the HD group were significantly higher than those in the non-HD group (COL1A1, P=0.021; COL3A1, P=.0.031). Incubating SSCT cells together with B2M for 6 h and 24 h led to increased mRNA expression of COL3A1 compared to that observed in vehicle control cells (p<0.001Conclusions: Our findings suggest that increased expression of COL1A1 and COL3A1 may be one mechanism by which HD patients develop CTS. Further, B2M may be responsible for elevating COL3A1 expression in HD patients with CTS.
Trends and risk factors of morbidity and disability adjusted life years for osteoarthritis from 1990 to 2019: systematic analysis for the Global Burden of Disease Study 2019
Authors: Yang Yang , Ni Weiyu , Tian Hongsen , Dai Zhanqiu , Fan Shunwu 
Published: July 2022

Abstract
Background
To report the level and trends of incidence and disability-adjusted life years (DALYs) due to osteoarthritis (OA) using age, sex, and the sociodemographic index (SDI) worldwide from 1990 to 2019 using data from the Global Burden of Disease Study 2019.
Methods
Morbidity and DALYs due to OA its subtypes were estimated using DisMod-MR 2.1. The estimated annual percentage change (EAPC) of the age-standardized incidence rate (ASIR)/age-standardized DALYs were estimated using a generalized linear model with a Gaussian distribution. Morbidity and DALYs were stratified on the basis of SDI. The strength and direction of the correlation between the EAPC/SDI and ASIR/age-standardized DALYs were measured using Pearson’s correlation coefficient.
Results
The total incidence of OA increased by 103.88%, from 20.34 million in 1990 to 41.47 million in 2019. Within 30 years, annual stability was observed in the global morbidity of OA of the hand, hip, knee, and other joints. The age-standardized incidence rate of hand OA decreased during the past three decades, whereas the other types of OA were elevated. Regions with a lower SDI had higher morbidity and DALYs. High body mass index (BMI) was a major risk factor for DALYs due to OA of the knee and hip.
Conclusions
Regions with a lower SDI had a greater OA burden. The estimated contribution of high BMI to DALYs due to OA of the knee and hip supports the need for urgent efforts to change the dietary structure and adjust the dietary plan.
Senescence Associated Secretory Proteins Induced in Lung Adenocarcinoma by Extended Treatment with Dexamethasone Enhance Migration and Activation of Lymphocytes
Authors: Parajuli Prahlad , Rosati Rayna , Mamdani Hirva , Wright Robert E , Hussain Zahin , Naeem Aroma , Dzinic Sijana , Polin Lisa , Gavande Navnath , Ratnam Manohar 
Published: July 2022

Abstract
There is a need to improve response rates of immunotherapies in lung adenocarcinoma (AC). Extended (7–14 day) treatment of high glucocorticoid receptor (GR) expressing lung AC cells with dexamethasone (Dex) induces an irreversible senescence phenotype through chronic induction of p27. As the senescence associated secretory phenotype (SASP) may have either tumor supporting or antitumor immunomodulatory effects, it was of interest to examine the effects of Dex-induced senescence of lung AC cells on immune cells. Dex-induced senescence resulted in sustained production of CCL2, CCL4, CXCL1 and CXCL2, both in vitro and in vivo. After Dex withdrawal, secretion of these chemokines by the senescent cells attracted peripheral blood monocytes, T-cells, and NK cells. Following treatment with Dex-induced SASP protein(s), the peripheral blood lymphocytes exhibited higher cell count and tumor cytolytic activity along with enhanced Ki67 and perforin expression in T and NK cells. This cytolytic activity was partially attributed to NKG2D, which was upregulated in NK cells by SASP while its ligand MICA/B was upregulated in the senescent cells. Enhanced infiltrations of T ad NK cells were observed in human lung AC xenografts in humanized NSG mice, following treatment with Dex. The findings substantiate the idea that induction of irreversible senescence in high-GR expressing subpopulations of lung AC tumors using Dex pretreatment enhances tumor immune infiltration and may subsequently improve the clinical outcome of current immunotherapies.
Modeling trade-offs among ecosystem services for agriculture in the “Sisal Belt” of Kilosa, Central Tanzania
Authors: Li Puyang , Hu Guohua , II B. L. Turner , Zhang Yujia 
Published: July 2022

Abstract
Context.Exploring novel ways to maintain a healthy landscape while improving human welfare based on different human-environment relationships and competing interests from multiple stakeholders is critical for sustainable development under the context of the surging “global land rush” underway, and of increasing interest to landscape sustainability science. Objectives.This paper aims to: (1) integrate perceptions across various stakeholders to create landscape-based decision-making scenarios based on alternative future development visions, and (2) demonstrate trade-offs and synergies among ecosystem and economic benefits in a landscape under the scenarios and discuss the means to incorporate results from analyses into landscape management and planning. Methods.We combined the use of two spatially explicit modeling tools, Future Land Use Simulation (FLUS) and Integrated Valuation of Ecosystem Services and Trade-offs (InVEST), to project future landscape patterns and predict changes in ecosystem services and commodity production under the three stakeholder-defined scenarios for the Kilsoa sisal belt region, Tanzania.Results.We found that all scenarios had higher commodity production values relative to the baseline conditions but various lower levels of ecosystem services. Carbon and water services may generate synergistic effects provided specific mitigation and payment mechanisms are installed.Conclusions.Our approach provides an effective platform by which landscape management and planning decisions can be determined. An effort as such may enrich the dialogue amongst multi-level stakeholders dealing with the environment and development in the area and inform policymaking to balance the challenging goals among food production, resource use, poverty alleviation, and environmental conservation.