bluuebunny/crossref_metadata_2025_split huggingface dataset:
Murine Thyroid IL-4 Expression Worsens Hypothyroidism on Iodine Restriction and Mitigates Graves Disease Development
Authors: Merakchi Karima , Djerbib Sami , Soleimani Manoocher , Dumont Jacques-Emile , Miot Françoise , De Deken Xavier 
Published: July 2022

AbstractCytokines are known to perturb thyroid function and the role of interleukin-4 (IL-4) in the pathogenesis of Graves disease (GD) remains controversial. In our mouse model overexpressing IL-4 in thyrocytes (Thyr-IL4), we have reported that adult mice preserved normal serum thyroxine despite an iodide uptake defect. In the present work, we evaluated if iodine restriction could uncover the thyroid deficiency in Thyr-IL4 animals as well as the role of pendrin overexpression as a compensatory mechanism. Moreover, using an experimental model of GD we investigated the effect of a local expression of IL-4 on the incidence of hyperthyroidism. Thyr-IL4 mice developed more rapidly elevated serum thyrotropin under low-iodine supply with thyroid enlargement and classical histological modifications. These hallmarks of hypothyroidism were all enhanced in Thyr-IL4 mice with complete pendrin invalidation. Following immunization, a lower proportion of Thyr-IL4 animals developed hyperthyroidism. Surprisingly, immunized Thyr-IL4 animals presented numerous leukocyte infiltrates, associated with increased intrathyroidal expression of IFN-γ. We have demonstrated that thyroid deficiency in Thyr-IL4 mice is partially compensated for by the excessive iodide content of the standard chow and the overexpression of pendrin in these animals. Furthermore, we have shown that the local expression of IL-4 in the thyroid attenuates GD progression, which was associated with enhanced thyroid infiltration by immune cells that could negatively affect thyroid function.
Joint Profiles of Sedentary Time and Physical Activity in Adults and their Associations with Cardiometabolic Health
Authors: Farrahi Vahid , Rostami Mehrdad , Dumuid Dot , Chastin Sebastien F. M. , Niemelä Maisa , Korpelainen Raija , Jämsä Timo , Oussalah Mourad 
Published: July 2022

ABSTRACT

Purpose
This study aimed to identify and characterize joint profiles of sedentary time and physical activity among adults and investigate how these profiles are associated with markers of cardiometabolic health.

Methods
The participants included 3,702 of the Northern Finland Birth Cohort 1966 at age 46 years, who wore a hip-worn accelerometer during waking hours and provided 7 consecutive days of valid data. Sedentary time, LPA, and MVPA on each valid day were obtained, and a data-driven clustering approach (“KmL3D”) was used to characterize distinct joint profiles of sedentary time and physical activity intensities. Participants self-reported their sleep duration and performed a submaximal step test with continuous heart rate measurement to estimate their cardiorespiratory fitness (peak heart rate). Linear regression was used to determine the association between joint profiles of sedentary time and physical activities with cardiometabolic health markers, including adiposity markers and blood lipid, glucose, and insulin levels.

Results
Four distinct groups were identified: “Active couch potatoes” (n = 1,173), “Sedentary light movers” (n = 1,199), “Sedentary exercisers” (n = 694), and “Movers” (n = 636). Although sufficiently active, Active couch potatoes had the highest daily sedentary time (>10 hours) and lowest LPA. Compared to Active couch potatoes, Sedentary light movers, Sedentary exercisers, and Movers spent less time in sedentary by performing more physical activity at light-intensity upward and had favorable differences in their cardiometabolic health markers after accounting for potential confounders (1.1%–25.0% lower values depending on the health marker and profile).

Conclusions
After accounting for sleep duration and cardiorespiratory fitness, waking activity profiles characterized by performing more physical activity at light-intensity upward, resulting in less time spent in sedentary, were associated with better cardiometabolic health.
Do temor da verdade ao medo da liberdade: as possibilidades de educação emancipadora na primeira infância a partir de Theodor Adorno e Paulo Freire
Authors: Toshie Irie Saito Heloisa , Borba da Costa Priscila 
Published: July 2022

A partir das teorias críticas de Theodor Adorno e de Paulo Freire, versamos sobre os impactos na humanidade da formação ou pseudoformação. Sob os conceitos “o temor da verdade” e o “medo da liberdade”, lançamos olhares sobre os entraves do amadurecimento da educação como projeto emancipatório, ainda revelada repressora que estanca a produção de pensamento crítico. O texto se alicerça nos autores supracitados acerca das características estruturantes para que a liberdade ocorra através da autoformação e autorreflexão e a importância do envolvimento do professor em uma educação como prática da liberdade contra a dominação. Com análises ensaísticas, pretendemos ressaltar uma demanda problemática de superação de uma perspectiva tradicional, burocrática e bancária do ensino de crianças para uma perspectiva integral dos sujeitos envolvidos na educação infantil, sujeitos estes, co-construtores do conhecimento.
Oropouche virus infection in patients with acute febrile syndrome: Is a predictive model based solely on signs and symptoms useful?
Authors: Durango-Chavez Hilda V. , Toro-Huamanchumo Carlos J. , Silva-Caso Wilmer , Martins-Luna Johanna , Aguilar-Luis Miguel Angel , del Valle-Mendoza Juana , Puyen Zully M. 
Published: July 2022

BackgroundOropouche fever is an infectious disease caused by the Oropouche virus (OROV). The diagnosis and prediction of the clinical picture continue to be a great challenge for clinicians who manage patients with acute febrile syndrome. Several symptoms have been associated with OROV virus infection in patients with febrile syndrome; however, to date, there is no clinical prediction rule, which is a fundamental tool to help the approach of this infectious disease.ObjectiveTo assess the performance of a prediction model based solely on signs and symptoms to diagnose Oropouche virus infection in patients with acute febrile syndrome.Materials and methodsValidation study, which included 923 patients with acute febrile syndrome registered in the Epidemiological Surveillance database of three arbovirus endemic areas in Peru.ResultsA total of 97 patients (19%) were positive for OROV infection in the development group and 23.6% in the validation group. The area under the curve was 0.65 and the sensitivity, specificity, PPV, NPV, LR + and LR- were 78.2%, 35.1%, 27.6%, 83.6%, 1.20 and 0.62, respectively.ConclusionsThe development of a clinical prediction model for the diagnosis of Oropouche based solely on signs and symptoms does not work well. This may be due to the fact that the symptoms are nonspecific and related to other arbovirus infections, which confuse and make it difficult to predict the diagnosis, especially in endemic areas of co-infection of these diseases. For this reason, epidemiological surveillance of OROV in various settings using laboratory tests such as PCR is important.
FORNER, Salvador y SENANTE, Heidy-Cristina (eds.), Miradas a Europa. Percepciones y relatos desde España. Madrid, Centro de Estudios Políticos y Constitucionales, 2020, 291 pp.
Authors: Vaquero Martínez Sergio 
Published: July 2022

Reseña del libro: FORNER, Salvador y SENANTE, Heidy-Cristina (eds.), Miradas a Europa. Percepciones y relatos desde España. Madrid, Centro de Estudios Políticos y Constitucionales, 2020, 291 pp.
Isolation, Characteristics, Differentiation and Exploitation of Human Amnion Mesenchymal Stem Cells
Authors: Thomas Fiona Macniesia , Gumpil Sandra Lisa , Simat Siti Fatimah , Subbiah Vijay Kumar 
Published: July 2022

Abstract
Human amnion is a favorable potential source of mesenchymal stem cells (MSC) for future cell-therapy-based clinical applications, because of the painless collection procedure and easy accessibility of the placenta. Human amnion mesenchymal stem cells (hAMCs) have multilineage differentiation ability and high proliferation ability, are non-tumorigenic and have a relatively low risk of rejection after transplantation. Given the beneficial properties of hAMCs, herein, we review the isolation methods and characteristics of hAMCs. Furthermore, we summarize current hAMC applications and preservation methods.
Methotrexate plus reduced or full-dose glucocorticoids for the treatment of active, moderate-to-severe Graves’ orbitopathy
Authors: Shen Liyun , Ye Lei , Zhu Wei , Jiao Qin , Zhou Yulin , Wang Shu , Wang Weiqing , Ning Guang 
Published: July 2022

Objective
A combination of glucocorticoids with mycophenolate is recommended by current guidelines to boost response to Graves’ orbitopathy (GO) therapy. This study was designed to evaluate the therapeutic effects and safety of methotrexate (MTX) plus reduced (3.0 g) or full-dose (4.5 g) i.v. methylprednisolone (MP) vs full-dose i.v. MP alone.

Design and methods
This was a prospective, randomized, observer-masked, single-center clinical trial conducted in a tertiary clinical center. Ninety-seven patients with active moderate-to-severe GO were screened and 90 patients underwent randomization between April 2018 and Oct 2019. All patients completed 12 weeks of treatment and received clinical assessment. The patients received either MP 4.5 g only, MP 4.5 g plus oral MTX, or MP 3.0 g plus oral MTX. The primary outcome was the CAS response at week 12. Secondary outcomes were adverse events and other individual ophthalmic parameters.

Results
At week 12, 53.3% of MP, 76.7% of reduced MP plus MTX, and 76.7% of MP plus MTX achieved a CAS response, although the difference was not significant (P = 0.1). The overall response rates of the MP group, the reduced MP plus MTX group, and the MP plus MTX group were 43.3%, 53.3%, and 60%, respectively (P = 0.5). Subgroup analysis found that smoking status interacted with marginal significance with treatment effect (P = 0.048). Importantly, adverse event incidence was significantly lower in the reduced MP + MTX group (P = 0.017).

Conclusions
Our study shows that reduced MP plus MTX therapy is effective and safer in treating active and moderate-to-severe GO patients than 4.5 g MP monotherapy.
Trends in Pediatric Rhabdomyolysis and Associated Renal Failure: A 10-Year Population-Based Study
Authors: Agharokh Ladan , Zaniletti Isabella , Yu Andrew G. , Lee Benjamin C. , Hall Matt , Williams Derek J. , Wilson Karen M. 
Published: July 2022

OBJECTIVES
Rhabdomyolysis in children is a highly variable condition with presentations ranging from myalgias to more severe complications like acute renal failure. We sought to explore demographics and incidence of pediatric rhabdomyolysis hospitalizations and rates of associated renal failure, as our current understanding is limited.

METHODS
This was a retrospective analysis using the Healthcare Cost and Utilization Project Kids’ Inpatient Database to identify children hospitalized with a primary diagnosis of rhabdomyolysis. Data were analyzed for demographic characteristics, as well as geographic and temporal trends. Multivariable logistic regression was used to identify characteristics associated with rhabdomyolysis-associated acute renal failure.

RESULTS
From 2006 to 2016, there were 8599 hospitalized children with a primary diagnosis of rhabdomyolysis. Overall, hospitalizations for pediatric rhabdomyolysis are increasing over time, with geographic peaks in the South and Northeast regions, and seasonal peaks in March and August. Though renal morbidity was diagnosed in 8.5% of children requiring hospitalization for rhabdomyolysis, very few of these patients required renal replacement therapy (0.41%), and death was rare (0.03%). Characteristics associated with renal failure included male sex, age greater than 15 years, and non-Hispanic Black race.

CONCLUSIONS
Though renal failure occurs at a significant rate in children hospitalized with rhabdomyolysis, severe complications, including death, are rare. The number of children hospitalized with rhabdomyolysis varies by geographic region and month of the year. Future studies are needed to explore etiologies of rhabdomyolysis and laboratory values that predict higher risk of morbidity and mortality in children with rhabdomyolysis.
Presentación 173
Authors: ARGUEDAS ABARCA MARIA FERNANDA 
Published: July 2022

En este texto se resumen los artículos varios que se publican en este número. El tema central de este número ha sido escrito por la Dra. Nancy Piedra Guillén, Directora de la Maestría Académica en Sociología de esta universidad, el cual se inserta como introducción a la sección central.
EL ESTADO Y EL DESARROLLO DE POLÍTICAS DE VIVIENDA EN CÓRDOBA, ARGENTINA (1914-1920)
Authors: Coch Federico Nicolás 
Published: July 2022

En este trabajo se reconstruye el rol del Estado, en su nivel municipal y provincial, respecto al desarrollo de políticas de vivienda en la ciudad de Córdoba entre 1914 y 1920. Se diferencian ambos niveles en un intento por matizar la idea de que el Estado es un agente unívoco. Se demuestra que los problemas de la vivienda fueron pensados de manera fragmentaria y coyuntural. Además, se relacionan estos resultados con las concepciones que los agentes estatales tenían sobre su rol desde el Estado, al indicar el desfase entre su perspectiva económica y social. Metodológicamente, se sostiene el trabajo mediante el análisis de fuentes de diferente procedencia: periódicos, labores parlamentarias, discursos políticos y documentos académicos del lapso en estudio.
LA FABRICACIÓN ESTÉTICA DE JESÚS JIMÉNEZ ZAMORA (SIGLOS XIX, XX Y XXI)
Authors: Brenes-Tencio Guillermo Alfonso 
Published: July 2022

El presente artículo analiza la figura histórica del presidente costarricense Jesús Jiménez Zamora (Cartago, 18 de junio de 1823-12 de febrero de 1897), desde la perspectiva de su fabricación estética, a mediados del siglo xix y los inicios del siglo xx. La figura de Jesús Jiménez ha sido estudiada, pormenorizadamente por la historiografía costarricense, desde el punto de vista de su personalidad y su labor como estadista (1863-1866 y 1868-1870). De ahí que el objetivo de esta investigación girará en torno a sus representaciones plásticas, tanto como caballero joven como caballero anciano. Asimismo, tampoco escapa de la atención de este escrito, el análisis de diversas representaciones retóricas de Jesús Jiménez como referente moral y patriótico por parte de algunos miembros de la intelectualidad costarricense.
Eksistensi Nilai-Nilai Pendidikan Karakter Siswa Sekolah Dasar
Authors: Susandi Ari , Mas’ula Siti , Setiawan Budi , Dirgayunita Aries , Fadilah Yulina 
Published: July 2022

This study aims to explore the existence of character education values for elementary school students with online learning and door to door learning system, by choosing descriptive qualitative as its implementation. The research location was MI Muhammadiyah 1 Probolinggo City. The informants in this study were teachers from grade 1 to grade 3, totaling six people. This study used a phenomenological type of research. Data obtained by direct observation, interviews and documentation. Data analysis was carried out through data reduction, data display, and verification. The results of this study are (1) teachers must be able to provide an online learning system to support the existence of character education values for elementary school students during online learning; (2) collaboration of online learning with door to door provides enormous benefits in the development of the character values; (3) the role of teachers in learning innovation and collaboration with parents can help optimizing the development and habituation of the character values in students. Penelitian ini bertujuan untuk mengeksplorasi eksistensi nilai-nilai pendidikan karakter siswa sekolah dasar dengan sistem pembelajaran online dan door to door, dengan memilih deskriptif kualitatif sebagai implementasinya. Tempat penelitian adalah MI Muhammadiyah 1 Kota Probolinggo. Informan dalam penelitian ini adalah guru kelas 1 hingga kelas 3 yang berjumlah enam orang. Penelitian ini menggunakan jenis penelitian fenomenologi. Data didapatkan dengan observasi langsung, wawancara serta dokumentasi. Analisis data dilakukan melalui reduksi data, display data, juga verifikasi. Hasil dari penelitian ini meliputi, (1) guru harus mampu mengembangkan sistem pembelajaran online untuk mendukung eksistensi nilai-nilai pendidikan karakter siswa sekolah dasar selama pembelajaran online; (2) kolaborasi pembelajaran secara daring atau online dengan door to door ini memberikan manfaat yang sangat besar dalam pengembangan nilai karakter; (3) peran guru dalam inovasi pembelajaran dan kerja sama dengan orang tua dapat membantu mengoptimalkan perkembangan dan pembiasaan nilai karakter dalam diri siswa.
PENINGKATAN KESEJAHTERAAN MASYARAKAT MELALUI PELATIHAN DIFERENSIASI PRODUK OLAHAN SUSU SAPI DESA NGEMBAL
Authors: Kustiandi Januar , Jaelani M. Iqbal , Khumairoh Ninik , Pakpahan Novirida , Azizah Rosidah Nurin , Hafidzoh Siti Ainun 
Published: July 2022

Abstrak: Produk olahan susu sapi di Desa Ngembal Kabupaten Malang merupakan produk unggulan yang banyak diproduksi secara mandiri oleh masyarakat. Namun, produk ini belum mampu memberikan kontribusi signifikan bagi kesejahteraan masyarakat khususnya para peternak dan pelaku UMKM. Pengabdian kepada Masyarakat ini bertujuan untuk meningkatkan keterampilan masyarakat dalam membuat varietas produk yang berbahan baku susu sapi segar menjadi produk yang bervariasi dan memiliki harga jual yang lebih tinggi. Pengabdian ini dilaksanakan melalui tahapan sosialisasi, pelatihan dan demonstrasi produksi. Kegiatan pelatihan diikuti secara antusias oleh para peserta yang terdiri dari peternak, pelaku UMKM produk olahan susu sapi, dan masyarakat secara umum. Melalui kegiatan pelatihan ini, pengetahuan dan kemampuan peserta pelatihan berkaitan dengan pengolahan susu, strategi diferensiasi produk dan strategi pemasaran semakin baik sehingga diharapkan mampu meningkatkan diversifikasi produk dan membuka peluang pasar baru. Abstract: Cows' milk products in Ngambat Village, Malang Regency are superior products that are produced independently by the community. However, this product has not been able to make a significant contribution to the welfare of the community, especially breeders and MSME players. This community service aims to improve community skills in making product varieties made from fresh cow's milk into varied products with higher selling prices. This service was carried out through the stages of socialization, training and production demonstrations. The training activity was followed enthusiastically by the participants consisting of breeders, MSME players for cow milk products, and the general public. Through this training activity, the knowledge and abilities of training participants related to milk processing, product differentiation strategies and marketing strategies are getting better so that it is expected to increase product diversification and open new market opportunities.
WORKSHOP PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS IT BAGI GURU-GURU SMP NEGERI 2 NEKAMESE KABUPATEN KUPANG
Authors: Astiti Kadek Ayu , Yusuf Yusniati H. Muh. , Lantik Vinsensius 
Published: July 2022

Abstrak: SMP Negeri 2 Nekamese Kabupaten Kupang merupakan sekolah model dengan jumlah siswa 253 dan jumlah guru 24 telah tersedia 5 LCD serta sebagian besar guru telah memiliki laptop yang dapat digunakan guru untuk menunjang proses pembelajaran, namun dari 24 guru penggunaan IT kurang dari 40% dan ketersediaan media pembelajaran berbasis IT masih sangat minim. Sementara berkembangnya teknologi informasi dan komunikasi serta tuntutan kurikulum saat ini mengharapkan guru-guru tingkat SMP mampu mengintegrasikan TIK dalam proses pembelajaran. Oleh karena itu, melalui kegiatan workshop pengembangan media pembelajaran berbasis IT ini diharapkan dapat meningkatkan pengetahuan dan keterampilan guru dalam penggunaan IT sebagai media pembelajaran yang menarik di kelas. Yang menjadi sasaran dalam kegiatan Pengabdian kepada Masyarakat (PKM) ini adalah semua guru mata pelajaran baik yang telah memiliki laptop maupun tidak dengan kemampuan penggunaaan IT di bawah rata-rata. Hasil dari kegiatan ini adalah diharapkan seluruh guru dapat memanfaatkan IT sebagai media pembelajaran sesuai mata pelajaran masing-masing sehingga tercipta kualitas pembelajaran yang efektif bagi siswa dan guru. Abstract: SMP Negeri 2 Nekamese is a model school with 253 students and 24 teachers have 5 LCDs available and most teachers already have laptops that can be used by teachers to support the learning process, but of 24 teachers the use of IT is less than 40% and the availability of media IT based learning is still very minimal. While the development of information and communication technology and the demands of the curriculum now expect junior-level teachers to be able to integrate ICT in the learning process. Therefore, through this workshop the development of IT-based learning media is expected to improve the knowledge and skills of teachers in using IT as an attractive learning media in the classroom. The target in this Community Service (PKM) activity is all subject teachers, both those who have laptops or not, with below average IT use abilities. The results of this activity are expected that all teachers can use IT as a learning medium in accordance with their respective subjects so as to create an effective learning quality for students and teachers.