bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN ANTAR USIA KEHAMILAN DENGAN JUMLAH LEUKOSIT PADA IBU HAMIL DI PUSKESMAS SLAHUNG PONOROGO
Authors: Suryani Eka , Widhiyastuti Endang 
Published: August 2022

Leukocytes are blood cells that play a role in the immune mechanism. Leukocytes are classified based on the presence or absence of granules in the cytoplasm of leukocytes, which consist of granulocytes and agranulocytes. The normal leukocyte count is 3200-10000/mm3 of blood. If the leukocytes are above the normal limit, it is called leukocytosis. Leukocytosis can be pathological or physiological. Physiological leukocytosis that occurs during pregnancy is common due to two reasons, namely a physiological stress and an increased inflammatory response. Physiological stress arises as a response to changes that occur in the body of pregnant women, including the workload of the heart, digestive system, metabolism, thereby stimulating the production of white blood cells to increase immunity. The inflammatory response is a form of the body's selective immune tolerance, immunosuppression and immunomodulation of the fetus. The purpose of this study was to determine the relationship between gestational age and leukocyte count in pregnant women at the Slahung Health Center, Ponorogo Regency, which was conducted in July 2021. This study uses an analytical observational analytic method with a cross sectional approach. This research was conducted by examining gestational age and leukocyte count in pregnant women with a total sample of 30 samples and using a total sampling technique. Examination of the number of leukocytes using the Hematology Analyzer URIT 3000 Plus. The results based on the average number of leukocytes from this study in the first trimester were 3.20 x103/mm3, in the second trimester 8.42 x103/mm3, and in the third trimester 12.56 x103/mm3. The results of test using the Kruskal-Walis obtained a significance value of 0.000 < 0.05. The results of this study can be concluded that there is a relationship between gestational age and the number of leukocytes in pregnant women
Use of airway stents to treat malignant tracheobronchial fistulas: Our six-year experience
Authors: Cengiz Seyhan Ekrem , Turan Demet , Akif Özgül Mehmet , Uğur Chousein Efsun , Özgül Güler , Çetinkaya Erdoğan 
Published: August 2022

Background: This study aims to investigate the indications, safety, complications, and long-term outcomes of airway stenting in the treatment of malignant tracheobronchial fistulas.
Methods: The medical records of a total of 34 patients (24 males, 10 females; mean age: 55.4+13 years; range, 23 to 76 years) with malignant tracheobronchial fistulas treated with airway stenting between February 2014 and August 2020 were retrospectively analyzed. Data including demographic features, diagnosis, symptoms, treatment, complications and outcomes were recorded.
Results: Thirty-eight airway stents were inserted in 34 patients with malignant tracheobronchial fistulas, including 19 patients with malignant tracheobronchial esophageal fistulas and 15 patients with bronchopleural fistulas. The clinical success and the technical success rates were 91% and 100%, respectively. No perioperative death or severe complications occurred. Chronic complications (>24 h) occurred in eight (23%) patients with malignant tracheobronchial fistula. Median follow-up was 3.5 (range, 1.4 to 5.5) months in patients with malignant tracheobronchial esophageal fistulas and 18 (range, 9.5 to 26.5) months in patients with bronchopleural fistulas. Mortality rates were 79% and 61%, respectively.
Conclusion: Airway stent insertion provides a secure and effective treatment for patients with malignant tracheobronchial fistulas.
Prognostic value of TAPSE/PASP ratio in right ventricular failure after left ventricular assist device implantation: Experience from a tertiary center
Authors: Sert Sena , Selçuk Nehir , Yıldırımtürk Özlem , Orhan Gökçen 
Published: August 2022

Background: In this study, we aimed to investigate the prognostic value of the tricuspid annular plane systolic excursion (TAPSE)/ pulmonary arterial systolic pressure (PASP) ratio in right ventricular failure patients undergoing left ventricular assist device implantation.
Methods: Between February 2013 and February 2020, a total of 75 heart failure patients (65 males, 10 females; median age: 54 years; range, 21 to 66 years) were retrospectively analyzed. The prognostic value of TAPSE/PASP ratio was assessed using the multivariate Cox regression models and confirmed using the Kaplan-Meier analyses.
Results: Forty-one (55.4%) patients had an ischemic heart failure etiology. The indication for assist device implantation was bridge to transplant in 64 (85.3%) patients. The overall survival rates at one, three, and five years following left ventricular assist device implantation were 82.7%, 68%, and 49.3%, respectively. Right ventricular failure was observed in 24 (32%) patients during follow-up. In the multivariate analysis, TAPSE/PASP was found to be independently associated with postoperative right ventricular failure (HR: 1.63; 95% CI: 1.49-2.23). A TAPSE/PASP of 0.34 mm/mmHg was found to be the most accurate predictor value, with lower ratios correlating with right ventricular failure. The Kaplan-Meier analysis showed a better overall survival using a TAPSE/PASP ? of 0.34 mm/mmHg (p<0.001).
Conclusion: A lower TAPSE/PASP ratio, particularly lower values than 0.34 mm/mmHg, strongly predicts right ventricular failure after left ventricular assist device implantation in patients with advanced heart failure.
Impact of Revegetation on Ecological Restoration of a Constructed Soil in a Coal Mining in Southern Brazil
Authors: Stumpf Lizete , Bertaso De Garcia Fernandez Maria , Miguel Pablo , Fernando Spinelli Pinto Luiz , Noremberg Schubert Ryan , Carlos Iuñes de Oliveira Filho Luís , Hipolito Montiel Tania , Da Silva Barbosa Lucas , Diego Leidemer Jeferson , Barbosa Duarte Thábata 
Published: August 2022

The main problems in the constructed soils are the generation of acid mine drainage promoted by the presence of coal debris in the overburden layer and the compaction of the topsoil promoted by the machine traffic when the material used in the overburden cover is more clayey. This book chapter aimed to show an overview of the impact of more than a decade of revegetation with different perennial grasses on the chemical, physical, and biological quality of constructed soil after coal mining. The study was carried out in a coal mining area, located in southern Brazil. The soil was constructed in early 2003 and the perennial grasses, Hemarthria altissima; Paspalum notatum cv. Pensacola; Cynodon dactylon cv Tifton; and Urochloa brizantha; were implanted in November/December 2003. In 11.5, 17.6 and 18 years of revegetation soil samples were collected and the chemical, physical, and biological attributes were determined. Our results show that liming is an important practice in the restoration of these strongly anthropized soils because this positively impacts the plants’ development, facilitating the roots system expansion. Biological attributes such as soil fauna and the microorganism’s population are the attributes that possibly takes longer to establish itself in these areas.
Efficacy of Capsaicin Rich Botanicals on the Aphid Population in Lablab (Dolichos lablab L.) under Organic Production System
Authors: Tamilselvi P. , Devi H. Usha Nandhini , Pugalendhi L. , Sumathi E. 
Published: August 2022

Aim: The growing concern for environmental safety and the demand for pesticide residue –free food worldwide have evoked interest in pest management through the use of botanicals, which offers a good alternative to manage the insect pests in an eco-friendly manner. This research was carried out to study the efficiency of botanicals on the aphid population in lablab under organic production system.
Study Design: The study was carried out in Randomized Block Design (RBD) with eight treatments and three replications.
Place and Duration of Study: The study was carried out at College Orchard, Department of Vegetable Science, Horticultural College and Research Institute, Tamil Nadu Agricultural University, Coimbatore during 2021 - 2022.
Methodology: The study was performed using chilli extract with three concentrations (2.5, 5.0 and 7.5%) and compared with other botanicals such as neem oil, neem seed kernel extract, garlic extract and panchagavya. The aphid population was counted visually before and 1, 3, 5 and 7 days after spraying.
Results: The results showed that after 7 days spraying 95.81 per cent of aphid population was reduced in T3 (7.5% chilli extract) followed by T2 & T1 (5 % & 2.5%) with a population reduction to the level of 95.62 and 91.54 per cent, respectively. This was followed by neem oil with a reduction of 83.50 per cent followed by garlic extract (79.74%), neem extract (76.94%) and panchagavya (62.81%). The inflorescence infestation was also lower in T3 (4.94) which were compared to control.
Conclusion: The application of chilli extract resulted in reduction of aphid population in lablab under organic cultivation. Infloresecence infestation was also recorded minimum in chilli extract treated plots. The chilli extract is non-toxic to humans and does not harm the environment and hence this can be utilized as an alternative to chemical pesticides.
MERCOSUL, ASSIMETRIAS E INTEGRAÇÃO PRODUTIVA: discussão e balanço 25 anos após a criação do bloco
Authors: Granato Leonardo 
Published: August 2022

O presente trabalho tem por objetivo discutir diferentes questões em torno do tema referente às assimetrias e seu tratamento no Mercosul, bem como do tema referente à questão produtiva. Para isso, efetuamos um perpassar histórico desde a gênese do bloco até o renovado espírito adquirido a partir de 2003, considerando-se especialmente os paradigmas econômicos e os modelos de desenvolvimento que têm exercido influência na região.Palavras-chave: Mercosul. Assimetrias. Integração Produtiva.MERCOSUR, ASIMETRÍAS E INTEGRACIÓN PRODUCTIVA: discusión y balance a 25 años de la creación del bloqueEl presente trabajo tiene por objetivo discutir diferentes cuestiones en torno al tema de las asimetrías y de su tratamiento en el Mercosur, así como también de la cuestión productiva. Para ello, efectuaremos un recorrido histórico desde la génesis del bloque hasta el renovado espíritu adquirido a partir de 2003, considerando especialmente los paradigmas económicos y los modelos de desarrollo que han influido en la región.Palabras claves: Mercosur. Asimetrías. Integración Productiva.MERCOSUR, ASYMMETRIES AND PRODUCTIVE INTEGRATION: discussion and balance after 25 years of the creation of the blocThe present paper aims to discuss different questions around the theme that refers to asymmetries and how they are treated in Mercosur, as well as its productive issues. With this aim, we performed a historical analysis from the genesis of the bloc until the renewed spirit that emerged after 2003, considering specially the economic paradigms and the developmental models that have exerted influence in the region.Keywords: Mercosur. Asymmetries. Productive integration.MERCOSUR, ASYMÉTRIES ET INTÉGRATION PRODUCTIVE: discussion et bilan après 25 ans de création du blocL’objectif de ce travail est de dicuter les différentes questions concernant le thème des asymétries et de leur traitement au sein du Mercosur ainsi que celui relatif à la question productive. Pour ce faire nous avons fait une rétrospective historique allant de la genèse du bloc jusqu’à un nouvel esprit acquis à partir de 2003, en prenant tout spécialement en considération les paradigmes économiques et les modèles de développement qui ont influencé la région.Mots-clés: Mercosur. Asymétries. Intégration Productive. Publicação Online do Caderno CRH no Scielo: http://www.scielo.br/ccrh Publicação Online do Caderno CRH: http://www.cadernocrh.ufba.br http://dx.doi.org/10.1590/S0103-49792016000200012
Access to 1,4‐Thiazepanes via Gold‐Catalyzed 7‐exo‐dig Thioallylation and their Cycloisomerization to Bicyclic [4.3.1] Bridgehead‐Olefinic Systems
Authors: Choury Mickael , Wagner Patrick , Rognan Charlou , Blond Gaëlle , Gulea Mihaela 
Published: August 2022

AbstractA series of 1,4‐thiazepanes were synthesized using gold‐catalysis from 1,3‐aminothioethers having two or three carbon stereocenters. The process consists in a 7‐exo‐dig cyclization with C−S bond formation and concomitant allyl S‐to‐C migration, which occurs intramolecularly as demonstrated by a cross‐over experiment. X‐ray crystal‐structure analysis of one product confirmed the expected stereochemistry. Two examples of reactions, azide‐alkyne cycloaddition (CuAAC) and N‐alkylation, illustrate the potential post‐functionalization of the synthesized 1,4‐thiazepanes. Finally, the N‐propargyl 1,4‐thiazepanes underwent a sulfur‐assisted 1,6‐enyne cycloisomerization, which led through a 6‐exo‐dig cyclization to N,S‐heterobicyclo[4.3.1] systems with a bridgehead double bond.magnified image
Fine‐mapping and replication of EWAS loci harboring putative epigenetic alterations associated with AD neuropathology in a large collection of human brain tissue samples
Authors: Palma‐Gudiel Helena , Yu Lei , Huo Zhiguang , Yang Jingyun , Wang Yanling , Gu Tongjun , Gao Cheng , De Jager Philip L. , Jin Peng , Bennett David A. , Zhao Jinying 
Published: August 2022

AbstractIntroductionOur previous epigenome‐wide association study (EWAS) of Alzheimer's disease (AD) in human brain identified 71 CpGs associated with AD pathology. However, due to low coverage of the Illumina platform, many important CpGs might have been missed.MethodsIn a large collection of human brain tissue samples (N = 864), we fine‐mapped previous EWAS loci by targeted bisulfite sequencing and examined their associations with AD neuropathology. DNA methylation was also linked to gene expression of the same brain cortex.ResultsOur targeted sequencing captured 130 CpGs (∼1.2 kb), 93 of which are novel. Of the 130 CpGs, 57 sites (only 17 included in previous EWAS) and 12 gene regions (e.g., ANK1, BIN1, RHBDF2, SPG7, PODXL) were significantly associated with amyloid load. DNA methylation in some regions was associated with expression of nearby genes.DiscussionTargeted methylation sequencing can validate previous EWAS loci and discover novel CpGs associated with AD pathology.
Palladium‐Catalyzed Aryldifluoromethylation of Aryl Halides with Aryldifluoromethyl Trimethylsilanes
Authors: Choi Kyoungmin , Mormino Michael G. , Kalkman Eric D. , Park John , Hartwig John F. 
Published: August 2022

AbstractDiaryl difluoromethanes are valuable targets for medicinal chemistry because they are bioisosteres of diaryl ethers and can function as replacements for diaryl methane, ketone, and sulfone groups. However, methods to prepare diaryl difluoromethanes are scarce, especially methods starting from abundant aryl halides. We report the Pd‐catalyzed aryldifluoromethylation of aryl halides with aryldifluoromethyl trimethylsilanes (TMSCF2Ar). The reaction occurs when the catalyst contains a simple, but unusual, dialkylaryl phosphine ligand that promotes transmetallation of the silane. Computational studies show that reductive elimination following transmetallation occurs with a low barrier, despite the fluorine atoms on the α‐carbon, due to coordination of the difluorobenzyl π‐system to palladium. The co‐development of a cobalt‐catalyzed synthesis of the silanes broadened the scope of the process including several applications to the synthesis biologically relevant diaryl difluoromethanes.
Sorbents for Atmospheric Water Harvesting: From Design Principles to Applications
Authors: Shi Wen , Guan Weixin , Lei Chuxin , Yu Guihua 
Published: August 2022

AbstractWater scarcity caused by climate change and population growth poses a grave threat to human society. Of the different water purification technologies put forward, one presents a promising strategy that is spatially or temporally non‐restricted—atmospheric water harvesting (AWH). Here we review recent progress in the design and study of AWH sorbents, ranging from the innovative chemistries to the integration of sophisticated architectures and functional components, and clarify the structure–property–performance relationship that governs the water capture and release processes. Features and limitations of each type of sorbents are summarized to elucidate the optimal working environments and modes. Progress in applications extending from water generation to thermal management and agriculture are discussed. Future developments regarding material modifications, performance measurements, and system optimizations are provided to overcome lingering barriers to sorbent design and implementation.
Two‐Dimensional‐on‐Three‐Dimensional Metal‐Organic Frameworks for Photocatalytic H2 Production
Authors: Wang Yang , Zhang Zhiyong , Li Jing , Yuan Yiwen , Yang Jun , Xu Wei , An Pengfei , Xi Shibo , Guo Jianping , Liu Bo , Li Jianfeng 
Published: August 2022

AbstractA MOF‐on‐MOF heterostructure is attractive in material science because of its potential combined effects in catalysis. However, precisely controlling the growth pattern at the metal–organic framework (MOF) nucleation stage to manipulate the metallic composition and structure dimensionality remain a challenge. Herein, we introduce a polyvinylpyrrolidone‐assist kinetic‐control strategy to achieve the “anti‐epitaxial growth” pattern of a foreign MOF nucleus on the (111) facets of UiO‐66‐NH2 octahedron seeds, and construct diverse two‐dimensional‐on‐three‐dimensional (2D‐on‐3D) MOF heterostructures (2D‐on‐3D Cu, Zn, Cd, Co, and Ni). Notably, the 2D‐on‐3D Cu exhibits a unique “dimensionality‐hybrid” effect in photocatalysis which led to a significant photoactivity enhancement over those of the traditional “dimensionality‐identical” 2D, 3D and 3D‐on‐3D MOF structures.
Peripheral nerve stimulation through a ‘dry’ peripheral nerve catheter for shoulder analgesia: a case report
Authors: Sondekoppam R. V. , Jindal A. , Ip V. , Tsui B. C. H. 
Published: August 2022

SummaryRevision shoulder surgery can pose significant analgesic challenges as locoregional blocks are often avoided to enable early recognition of iatrogenic nerve injuries. Our case describes the utilisation of pre‐operative and intra‐operative low‐frequency percutaneous peripheral nerve stimulation via a ‘dry’ interscalene catheter, inserted pre‐operatively for a patient presenting for revision total shoulder arthroplasty who was experiencing significant shoulder joint pain despite a prior total shoulder arthroplasty. The clinical considerations and safety aspects are discussed further.
Development of renewable thermosetting polymers based on grape seed oil derivatives
Authors: Gaglieri Caroline , Alarcon Rafael Turra , Magri Raquel , North Michael , Bannach Gilbert 
Published: August 2022

AbstractThe demand for polymeric materials increases year by year, and most of them are derived from nonrenewable sources, and their consume has been increasing year by year. Therefore, there is a demand for research on bioderived polymers that are viable to be produced on an industrial scale. Based on the lack of polymers produced exclusively using monomers derived from vegetable oils, this paper shows the syntheses of renewable thermosetting polymers derived exclusively from grape seed oil, which is a by‐product from the wine and grape juice industries. After the evaluation of the effect of using or not catalyst, it was determined that increasing 1‐methylimidazole amount in the monomer mixture provides the decreasing of parallel reactions. However, thermal and mechanical properties, as well as the crosslinking density of polymers do not change significantly using 1.0% or 5.0% of catalyst (the minimal amounts needed to favor the esterification). Based on the characterization, the final polymers are not favorable in applications that require high mechanical impacts. However, they would be excellent as coatings due to their elevated crosslinking density, hydrophobic properties and homogenous surface. In addition, based on the properties observed under UV‐light, they can also be used as luminescent materials.
Münchens tiefste Baugrube – Der neue Haltepunkt Marienhof für die 2. S‐Bahn‐Stammstrecke
Authors: Meier Joachim , Böhm Sebastian 
Published: August 2022

AbstractDie Deutsche Bahn AG betreibt im Großraum München ein weitverzweigtes S‐Bahn‐Netz. Alle Linien vereinigen sich im Innenstadtbereich zwischen den Haltepunkten Laim und Ostbahnhof zur sog. Stammstrecke, die seit 1972 in Betrieb ist. Die auf rd. 11 km Länge durchgängig zweigleisige Strecke zählt mit einer Zugfolgezeit von 120 s zu den am stärksten befahrenen Strecken Deutschlands. Mit Blick auf den Megatrend Urbanisierung und die Forderung klimafreundlicher innerstädtischer Transportmöglichkeiten wird das bereits seit den 1990er‐Jahren verfolgte Ausbauprojekt „2. S‐Bahn‐Stammstrecke München“ seit dem symbolischen ersten Spatenstich am 5. April 2017 in die Tat umgesetzt. Die immer intensivere Verdichtung der urbanen Lebensräume führt aber auch zu neuen Herausforderungen. Für die Erweiterung der bestehenden öffentlichen Infrastruktur und des öffentlichen Personennahverkehrs stehen im innerstädtischen Raum kaum mehr geeignete Flächen zur Verfügung, sodass oft nur das Ausweichen in den Untergrund bleibt. Gleichzeitig steigen die Anforderungen an nachhaltiges Bauen mit einem möglichst kleinen CO2‐Fußabdruck, stadtverträglichen Bauzeiten, geringen Lärm‐ und Staubemissionen und Erschütterungen sowie wenigen Transporten und insgesamt möglichst geringen Auswirkungen auf angrenzende Lebensräume. Am Beispiel der Umschließung Münchens bis dato tiefster Baugrube wird in diesem Bericht aufgezeigt, wie ein hochkomplexes und bautechnisch höchst anspruchsvolles Bauwerk im Einklang mit den vorgenannten Herausforderungen und der Hilfe modernster Werkzeuge, Bauverfahren und digitaler Arbeitsprozesse hergestellt wird. Besonderes Augenmerk gilt der Herstellung der gefrästen Schlitzwände. Die in weiterentwickelter Form auch für die anstehenden Lockerböden mit komplexer Schichtfolge eingesetzte Schlitzwandfräse wird für die Herstellung immer tiefer werdender Baugruben zunehmend an Bedeutung gewinnen und auch in Deutschland ausgewiesener Bestandteil des digital vernetzten Bauens sein.
S21 Flughafentunnel PfA 1.3a – Ausführungsplanung der Flughafenanbindung
Authors: Niesel Isabelle , Hammerschmidt Dirk , Schleith Alexander , Koch Fabian 
Published: August 2022

AbstractDie Baumaßnahme „S21 Flughafentunnel PfA 1.3a“ ist Bestandteil des Großprojekts Stuttgart–Wendlingen–Ulm und beinhaltet ca. 5 km der Hochgeschwindigkeitsstrecke entlang der A8 sowie die Anbindung an den Flughafen Stuttgart. Die Bauleistung umfasst u. a. 1,4 km Tröge und Tunnel in offener Bauweise, 3,5 km Tunnel in bergmännischer Bauweise, zwölf Brücken‐ und Durchlassbauwerke sowie die Einschnitt‐ und Dammbauwerke der Neubaustrecke. Mit der Ausführung der Baugruben sowie der Spezialtiefbauarbeiten entstehen zahlreiche Schnittstellen zu dem Ingenieurbau, dem Streckenbau und den bestehenden Bauwerken. In dem Übergangsbereich zwischen offener und bergmännischer Bauweise ergeben sich aufgrund der Herstellreihenfolge komplexe Mischsysteme aus Rückverankerung, Vernagelung, Aussteifung und Totmannkonstruktionen. Die Neubaustrecke gründet auf der Verfüllung und den Ingenieurbauwerken der Tröge und Tunnel in offener Bauweise. Die anspruchsvolle Aufgabe bei der Herstellung der Pfähle für die Gründung der Eisenbahnüberführung an der B312 war die unmittelbare Nähe der Gründungspfähle zum Bestandstrog. Die Übertragung von horizontalen Bettungskräften auf den Trog wird durch die Herstellung eines Ringspalts verhindert. Im Wesentlichen soll in dem folgenden Bericht auf die Planung der Baugruben und die damit verbundenen Schnittstellen im Rahmen des Projekts S21 PfA 1.3a eingegangen werden. Hierzu ist eine gesamtheitliche Betrachtung der Ausführungsplanungen erforderlich.