bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laminar Forced Convection MHD Couette-Poiseuille Flow with Viscous and Joule Dissipations
Authors: Sarkar B. C. 
Published: September 2022

The laminar forced convection MHD Couette-Poiseuille flow of a viscous incompressible fluid with the viscous and Joule dissipations has been studied. Two different orientations of the wall thermal boundary-conditions have been considered, namely: the constant heat-flux at the upper moving plate with the adiabatic stationary lower plate and the constant heat flux at the stationary lower plate with an adiabatic moving upper plate. The governing equations are solved analytically. It is observed that the fluid velocity increases near the stationary plate and it decreases near the moving plate with an increase in magnetic parameter. The temperature field is significantly affected by the modified Brinkman number. The fluid temperature increases when the lower plate is adiabatic and the upper plate is at positive constant heat flux while it decreases in case the lower plate is at negative constant heat flux and the upper plate is adiabatic with an increase in modified Brinkman number for the combined effects of viscous and Joule dissipations. Further, the fluid temperature decreases for positive heat flux case while it increases for negative heat flux case with an increase in either magnetic parameter or velocity parameter when the combined effects of viscous and Joule dissipations are taken into account.
Women’s Economic Status in the Ottoman Turkish Novel and the Pioneering Portrayal of Women’s Work in Fatma Aliye’s Novels, Refet and Udî
Authors: Canbaz Yumusak Firdevs 
Published: September 2022

In this article, Ottoman women’s economic status, work experiences in the public sector, and their assets were discussed and examined Fatma Aliye’s (1862-1936) novels Refet (1896) and Udî (1898). These two novels are the first Ottoman-Turkish novels that problematize these matters. Refet relates the adventures of a young woman who graduates from one of the Female Teachers Training Colleges (Darülmuallimat), the first of which was opened in 1870, and who goes on to become a teacher. As such, it constitutes a valuable portrayal of how the teaching colleges were established and what they meant for the Ottoman women. These essential and permanent historical developments laid the foundation for legal rights to be gained after the establishment of the Republic, and Refet is the first Turkish novel to deal with this subject matter. Additionally, Refet (1896), appears as the first Turkish novelistic portrayal of teaching as a profession ‘suitable’ for women. Between Refet and Udî, there is intertextuality. Bedia, the protagonist of Udî, is inspired by Refet and requests Fatma Aliye to write about her life; hence, the author develops Udî as an early work of metafiction. Bedia makes a livelihood in Udî by teaching oud lessons. It's no accident that both women in these novels work as teachers. Teaching is regarded as one of the most female-friendly professions.
Woman, Gender and Story in a Digitalized World: A Content Analysis for Digital Storytelling
Authors: Mutlu Cemre Gül 
Published: September 2022

Understanding social reality is an important requirement in social sciences research. Women's studies is a social sciences research area that seeks to understand social facts with a view to reveal the reasons and solutions of all issues that cause discrimination against women, especially gender inequality. Through its technology-supported narrative inquiry approach, digital storytelling can be a means to reveal meaning, especially in community-based research. In this context, this study aims to conduct an in-depth study of digital storytelling in researches that have been conducted in the context of Women's Studies and gender. In line with the purpose of the research, a systematic literature analysis was carried out for research using digital narrative in that context. Content analysis was applied to 42 articles that can be accessed for research purposes in the databases of Web of Science (WOS), Scopus, Science Direct and Ebscohost, without time limitation. According to the findings of the research; It has been determined that digital storytelling is used at a very limited level and mostly as a data analysis method in studies conducted in the context of Women's Studies and gender. However, it has been concluded that digital narrative is used in studies focusing especially on women who are exposed to multiple discrimination. In addition to this, it has been revealed that digital storytelling can contribute positively to the well-being and socialization of the participants as well as the development of self-efficacy of the participants in creating social awareness about women's issues. Based on the results of the research, digital storytelling in women's studies and gender studies were discussed from various angles and various suggestions were given regarding the contributions it can offer.
6DOF knee kinematic alterations due to increased load levels
Authors: Yang Tao , Huang Yaxiang , Zhong Guoqing , Kong Lingchuang , Yan Yuan , Lai Huahao , Zeng Xiaolong , Huang Wenhan , Zhang Yu 
Published: September 2022

Whether load carriage leads to six-degrees-of-freedom (6DOF) knee kinematic alterations remains unclear. Exploring this mechanism may reveal meaningful knee kinematic information that can be used to improve load carriage conditions, the design of protective devices, and the knowledge of the effects of load carriage on knees. We recruited 44 subjects to explore kinematic alterations from an unloaded state to 60% bodyweight (BW) load carriage. A three-dimensional gait analysis system was used to collect the knee kinematic data. One-way repeated analysis of variance (ANOVA) was used to explore the effects of load levels on knee kinematics. The effects of increasing load levels on knee kinematics were smooth with decreased or increased trends. We found that knees significantly exhibited increased lateral tibial translation (up to 1.2 mm), knee flexion angle (up to 1.4°), internal tibial rotation (up to 1.3°), and tibial proximal translation (up to 1.0 mm) when they went from an unloaded state to 60%BW load carriage during the stance phase (p &lt; 0.05). Significant small knee adduction/abduction angle and posterior tibial translation alterations (&lt;1°/mm) were also identified (p &lt; 0.05). Load carriage can cause significant 6DOF knee kinematic alterations. The results showed that knee kinematic environments are challenging during increased load. Our results contain kinematic information that could be helpful for knee-protection-related activities, such as target muscle training to reduce abnormal knee kinematics and knee brace design.
Case Report: Three-dimensional printed prosthesis reconstruction for patello-femoral large osteochondral defects in a patient with distal femoral giant cell tumour: A case report
Authors: Yuan Dechao , Fang Xiang , Lei Senlin , Banskota Nishant , Kuang Fuguo , Gou Yawei , Zhang Wenli , Duan Hong 
Published: September 2022

Background: The restoration and reconstruction of patello-femoral large osteochondral defects caused by bone tumours are challenging because of the local recurrence rate and the joint’s mechanical complexity. Although three-dimensional (3D)-printed prostheses are commonly adopted for tumour-induced bone defect reconstruction, patello-femoral osteochondral reconstruction with 3D-printed prostheses is rarely reported.Case presentation: A 44-year-old female patient with progressive swelling and pain in the left knee for 6 months was diagnosed with Campanacci Grade II giant cell tumour (GCT). She underwent intralesional curettage combined with autografting and internal fixation, after which complications of deep infection arose. The patient then underwent internal fixation removal and cement packing. Afterwards, the pain of the affected knee persisted for 11 months, and bone cement removal plus 3D-printed modular prosthesis reconstruction was performed. At the last follow-up 27 months after surgery, she was pain free, the Musculoskeletal Tumour Society (MSTS) score improved from 15/30 to 29/30, the Visual Analogue Scale (VAS) score decreased from 7 to 0, and knee flexion increased from 50° to 130°. X-ray images 22 months after surgery showed that the prosthesis and screws were in a stable position, and callus formation was found at the prosthesis-bone interface.Conclusions: A 3D-printed modular prosthesis may be a useful treatment option for the surgical reconstruction of GCT-induced patello-femoral large osteochondral defects. The firm fixation, osseointegration, and favourable congruency of the 3D-printed prosthesis with the adjacent articular surface can achieve long-term knee function and stability.
Signature of gene expression profile of liver sinusoidal endothelial cells in nonalcoholic steatohepatitis
Authors: Wang Yang , Zhang Yifan , Li Yimin , Liu Yun , Liu Yulan 
Published: September 2022

Background: There has been emerging evidence that liver sinusoidal endothelial cells (LSECs) play an important role in the pathogenesis of nonalcoholic steatohepatitis (NASH). This study aims to figure out the signature of the gene expression profile of LSECs in NASH and to explore potential biomarkers related to damaged LSECs in NASH.Methods and materials: Animal experiments were performed to demonstrate the significant structural damage of LSECs in the NASH model. To further understand the functional changes of these damaged LSECs in NASH, we used the public GEO database that contained microarray data for the gene expression of LSECs in NASH and normal mouse liver. Differentially expressed genes (DEGs) were analyzed, and further Gene Ontology (GO) enrichment analysis was performed to understand the functional changes. The hub genes were then identified and validated via external GEO databases.Results: There was significant structural damage to LSECs in the NASH model, accompanied by remarkable functional changes of LSECs with 174 DEGs (156 upregulated and 18 downregulated genes). The functions of these DEGs were mainly enriched in the inflammatory reactions and immune responses. Nine specifically expressed hub genes were identified. Among them, CCL4 and ITGAX showed the most significant correlation with NASH, with AUROC of 0.77 and 0.86, respectively. The protein–protein interaction network, mRNA–miRNA interaction network, and ceRNA network were further predicted.Conclusion: LSECs show significant structural damage and functional changes in NASH. The LSEC-related DEGs, such as CCL4 and ITGAX, might be promising biomarkers as well as potential treatment targets for NASH.
Research progress on Th17 and T regulatory cells and their cytokines in regulating atherosclerosis
Authors: Wang Qiong , Wang Yurong , Xu Danyan 
Published: September 2022

BackgroundCoronary heart disease due to atherosclerosis is the leading cause of death worldwide. Atherosclerosis is considered a chronic inflammatory state in the arterial wall that promotes disease progression and outcome, and immune cells play an important role in the inflammatory process.PurposeWe review the mechanisms of CD4+T subsets, i.e., helper T17 (Th17) cells and regulatory T cells (Tregs), in regulating atherosclerosis, focusing on the role of interleukin (IL)-17, IL-10, and other cytokines in this disease and the factors influencing the effects of these cytokines.ResultsIL-17 secreted by Th17 cells can promote atherosclerosis, but few studies have reported that IL-17 can also stabilize atherosclerotic plaques. Tregs play a protective role in atherosclerosis, and Th17/Treg imbalance also plays an important role in atherosclerosis.ConclusionThe immune response is important in regulating atherosclerosis, and studying the mechanism of action of each immune cell on atherosclerosis presents directions for the treatment of atherosclerosis. Nevertheless, the current studies are insufficient for elucidating the mechanism of action, and further in-depth studies are needed to provide a theoretical basis for clinical drug development.
Clinical outcomes and cumulative healthcare costs of TAVR vs. SAVR in Asia
Authors: Tan Elise Chia-Hui , Lee Yung-Tsai , Kuo Yu Chen , Tsao Tien-Ping , Lee Kuo-Chen , Hsiung Ming-Chon , Wei Jeng , Lin Kuan-Chia , Yin Wei-Hsian 
Published: September 2022

ObjectivesThis study compared transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) in terms of short- and long-term effectiveness.MethodsThis retrospective cohort study based on nationwide National Health Insurance claims data and Cause of Death data focused on adult patients (n = 3,643) who received SAVR (79%) or TAVR (21%) between 2015 and 2019. Propensity score overlap weighting was applied to account for selection bias. Primary outcomes included all-cause mortality (ACM), hospitalization for heart failure, and a composite endpoint of major adverse cardiac events (MACE). Secondary outcomes included medical utilization, hospital stay, and total medical costs at index admission for the procedure and in various post-procedure periods. The Cox proportional-hazard model with competing risk was used to investigate survival and incidental health outcomes. Generalized estimation equation (GEE) models were used to estimate differences in the utilization of medical resources and overall costs.ResultsAfter weighting, the mean age of the patients was 77.98 ± 5.86 years in the TAVR group and 77.98 ± 2.55 years in the SAVR group. More than half of the patients were female (53.94%). The incidence of negative outcomes was lower in the TAVR group than in the SAVR group, including 1-year ACM (11.39 vs. 17.98%) and 3-year ACM (15.77 vs. 23.85%). The risk of ACM was lower in the TAVR group (HR [95% CI]: 0.61 [0.44–0.84]; P = 0.002) as was the risk of CV death (HR [95% CI]: 0.47 [0.30–0.74]; P = 0.001) or MACE (HR [95% CI]: 0.66 [0.46–0.96]; P = 0.0274). Total medical costs were significantly higher in the TAVR group than in the SAVR in the first year after the procedure ($1,271.89 ± 4,048.36 vs. $887.20 ± 978.51; P = 0.0266); however, costs were similar in the second and third years after the procedure. The cumulative total medical costs after the procedure were significantly higher in the TAVR group than in the SAVR group (adjusted difference: $420.49 ± 176.48; P = 0.0172).ConclusionIn this real-world cohort of patients with aortic stenosis, TAVR proved superior to SAVR in terms of clinical outcomes and survival with comparable medical utilization after the procedure.
FN1 promotes prognosis and radioresistance in head and neck squamous cell carcinoma: From radioresistant HNSCC cell line to integrated bioinformatics methods
Authors: Tang Xiaojun , Tang Qinglai , Yang Xinming , Xiao Zi-An , Zhu Gangcai , Yang Tao , Yang Qian , Zhang Ying , Li Shisheng 
Published: September 2022

Background: Radioresistance in head and neck squamous cell carcinoma (HNSCC) patients means response failure to current treatment. In order to screen radioresistant biomarkers and mechanisms associated with HNSCC, differentially expressed genes (DEGs) associated with radioresistance in HNSCC were investigated.Methods: The HNSCC cell line with radioresistance, Hep2-R, was established and detected the radiosensitivity using MTT, colony formation assay and flow cytometry analysis. Clariom™ D chip was applied to compare DEGs between Hep2 and Hep2-R groups and build the differential gene expression profiles associated with radioresistance in HNSCC. Bioinformatic analysis were used to find biological functions and pathways that related to radioresistance in HNSCC, including cell adhesion, cytochrome P450 and drug metabolism. Gene Expression Omnibus (GEO) datasets were selected to verify DEGs between HNSCC radioresistant cells and tissues. The representation of DEGs were validated between HNSCC patients with complete response and post-operative radiation therapy failure. In addition, we evaluated the clinical prognosis of DEGs using The Cancer Genome Atlas (TCGA) database.Results: 2,360 DEGs (|Fold Change|&gt;1.5, p &lt; 0.05) were identified between Hep2 and Hep2-R, including 1,144 upregulated DEGs and 1,216 downregulated DEGs. They were further verified by HNSCC radioresistant cells and tissues in GEO. 13 radioresistant DEGs showed same difference in expression level between cells and tissues. By comparing 13 DEGs with HNSCC patients, upregulations of FN1, SOX4 and ETV5 were found identical with above results. Only FN1 was a prognostic indicator of HNSCC in TCGA.Conclusion: FN1 is the potential novel biomarker for predicting poor prognosis and radioresistance in HNSCC patients. Overexpression of FN1 plays an important role in the tumorigenesis, prognosis and radioresistance of HNSCC.
High Expression of ATP6V1C2 Predicts Unfavorable Overall Survival in Patients With Colon Adenocarcinoma
Authors: Li Guanghua , Huang Jiahua , Chen Sile , He Yulong , Wang Zhixiong , Peng Jianjun 
Published: September 2022

Aims: Colon adenocarcinoma (COAD) is responsible for 90% of all colorectal cancer cases and is one of the most common causes of cancer-related deaths worldwide. ATP6V1s (cytosolic V1 domain of vacuolar adenosine triphosphatase) participate in the biological process of transporting hydrogen ions and are implicated in tumor growth and metastasis. ATP6V1C2 as a family member has been documented to associate with esophageal carcinoma and renal clear cell carcinoma, while its roles in COAD remain elusive.Methods: The expression status, potential molecular mechanism, and prognostic value of ATP6V1C2 in COAD were investigated using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. In addition, its biological roles in COAD were explored through in vitro studies.Results: ATP6V1C2 showed a significantly higher expression level in COAD compared with matched non-cancerous tissues. High expression of ATP6V1C2 predicted a shorter overall survival both in TCGA and GEO COAD datasets, and ATP6V1C2 was identified as an independent factor associated with overall survival in COAD. Bioinformatic analyses showed that high expression of ATP6V1C2 was associated with high epithelial–mesenchymal transition (EMT) score and Wnt signaling pathway was significantly enriched from differentially expressed genes between ATP6V1C2-high and -low group. We also found that high expression of ATP6V1C2 could decrease pathway activity of CD8 T effector implicated in tumor microenvironment (TME). In vitro study revealed that ATP6V1C2 knockdown resulted in aberrant expression of Wnt- and EMT-related genes and inhibited COAD cell proliferation and growth.Conclusion: This is the first study to reveal the molecular functions of ATP6V1C2 in COAD. Our study suggests that overexpressed ATP6V1C2 might promote EMT by activating Wnt signaling pathway, resulting in cancer metastasis and poor prognosis. This study paves the way for understanding potential molecular mechanisms and therapeutic perspectives in COAD.
Prognostic characteristics and clinical response to immunotherapy targeting programmed cell death 1 for patients with advanced gastric cancer with liver metastases
Authors: Liang Huayuan , Li Zhiwei , Huang Zhicheng , Wu Chaorui , Qiu Yaopeng , Liang Yanrui , Chen Xinhua , Li Fengping , Xu Zhou , Li Guoxin , Liu Hao , Zhao Liying 
Published: September 2022

BackgroundThe specific efficacy of immunotherapy for patients with liver metastases of gastric cancer is unclear. This study set out to explore the treatment response and related prognostic factors for patients with liver metastases of gastric cancer treated with immunotherapy.Patients and methodsThis retrospective cohort study included 135 patients with unresectable advanced gastric cancer. According to the presence of liver metastases and/or first-line treatment with immunotherapy, patients were divided into the following three groups: I-LM(-) group(patients without liver metastases treated with immunotherapy, n=66), I-LM(+) group(patients with liver metastases treated with immunotherapy, n=36), C-LM(+) group(patients with liver metastases treated with chemotherapy and/or target therapy, n=33). Cox regression analyses were used to identify factors associated with survival in all patients and the three groups, respectively.ResultsFor the patients with liver metastases treated with immunotherapy, multivariate analysis showed that only the presence of peritoneal metastases was significantly associated with shorter PFS [hazard ratios (HR), 3.23; 95% CI, 1.12-9.32; P=0.030] and the patients with peritoneal metastases had shorter median PFS than patients without peritoneal metastases(3.1 vs 18.4 months; P=0.004), while the objective response rate was 100% in patients with HER2-positive (2 complete radiographic responses and 2 partial responses; 3 of 4 patients were still ongoing benefits [median follow-up time, 15.3 months ; interquartile range(IQR), 6.3-17.9 months]).ConclusionsThe findings suggest that patients with various types of gastric cancer liver metastases respond differently to immune checkpoint inhibitors, HER2-positive patients may derive clinical benefits from immune checkpoint inhibitors, while the presence of peritoneal metastases is associated with resistance.
Prognostic value of TIGIT in East Asian patients with solid cancers: A systematic review, meta-analysis and pancancer analysis
Authors: Li Sicong , Li Lanxing , Pan Tianyan , Li Xiaoqun , Tong Yujia , Jin Yongdong 
Published: September 2022

BackgroundT-cell immunoreceptor with Ig and ITIM domains (TIGIT) participates in tumor immune escape by delivering inhibitory signals to T cells. The purpose of this article was to assess the prognostic value of TIGIT and its immunological function in solid cancers.MethodsThree databases were searched for relevant articles. The main endpoints were overall survival (OS), progression-free survival (PFS), recurrence-free survival (RFS), and disease-free survival (DFS). Hazard ratios (HR) were pooled by using fixed-effects or random-effects models. Pancancer analysis of TIGIT was performed based on public online databases, mainly The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and UCSC Xena. The possible relationships between TIGIT expression and the tumor microenvironment (TME), infiltration of immune cells, immune-related genes, tumor mutation burden (TMB), and microsatellite instability (MSI) were revealed in this article.ResultsSixteen studies met the inclusion criteria. High expression of TIGIT was associated with worse OS [HR= 1.73, 95% confidence interval (CI) 1.50, 1.99], PFS (HR = 1.53, 95% CI [1.25, 1.88]), RFS (HR = 2.40, 95% CI [1.97, 2.93]), and DFS (HR= 6.57, 95% CI [0.73, 59.16]) in East Asian patients with solid cancers. TIGIT expression was positively correlated with immune infiltration scores and infiltration of CD8 T lymphocytes in all of the cancers included. TIGIT was found to be coexpressed with the genes encoding immunostimulators, immunoinhibitors, chemokines, chemokine receptors, and major histocompatibility complex (MHC), especially in gastroesophageal cancer. TMB and MSI were also associated with TIGIT upregulation in diverse kinds of cancers.ConclusionHigh expression of TIGIT is associated with poorer prognosis in East Asian patients with solid cancers. TIGIT is a novel prognostic biomarker and immunotherapeutic target for various solid cancers because of its activity in cancer immunity and tumorigenesis.