bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of risk and factors associated with obstructive sleep apnea‐hypopnea syndrome in an adult population in Kinshasa, Democratic Republic of Congo
Authors: Tete Boniface , Albdewi Mohamad Ammar , Nkodila Aliocha , Muhala Blaise , Akilimali Pierre , Bisuta Serge , Makulo Jean Robert , Kayembe Jean Marie 
Published: May 2022

SummaryObstructive sleep apnea‐hypopnea syndrome (OSAHS) is an underdiagnosed and lesser known disease in sub‐Saharan Africa. We believe that this is the first descriptive and analytical cross‐sectional study in Kinshasa (from February 1 to October 31, 2021), which included respondents aged ≥18 years. The study aimed to determine the prevalence of the risk and factors associated with OSAHS. Each participant signed a free and informed consent. Statistical analyses were performed using XLStat 2020 and the Statistical Package for the Social Sciences version 24 for Windows. Odds ratios (ORs) were calculated to determine the degree of association between these variables and a high risk of OSAHS. The significance threshold was p < 0.05 and confidence interval (CI) at 95%. There were 4,162 participants, including 2,287 men (54.9%), with an mean (SD) age of 32 ± 12.6 years. The prevalence of OSAS risk was 17.4% and 7.9% for men and women, respectively. The associated risk factors were male sex (OR 4, 95% CI 3.20–5.54), hypertension (OR 6.7, 95% CI 4.87–9.30), age ≥60 years (OR 8.7, 95% CI 4.07–18.88), obesity/overweight (OR 1.94, 95% CI 1.13–3.78), and excessive daytime sleepiness (OR 2.63, 95% CI 2.05–3.56). The risk of OSAS in Kinshasa is high and it increases with age, male sex, obesity, and hypertension. The Snoring, Tiredness, Observed apnea, high blood Pressure, Body mass index, Age, Neck circumference, and male Gender (STOP‐BANG) questionnaire is an easy‐to‐use tool for diagnostic orientation.
TRPM2 regulates autophagy to participate in hepatitis B virus replication
Authors: Chen Liyan , Zhu Liying , Lu Xingyu , Ming Xiaoyu , Yang Baoshan 
Published: May 2022

AbstractHepatitis B virus (HBV) affects over 300 million people across the world and is further associated with the self‐digesting process of autophagy. Accordingly, the current study set out to explore the role of transient receptor potential cation channel subfamily M member 2 (TRPM2) in HBV replication. Firstly, Huh‐7 cells were transfected with the pHBV1.3 plasmid to detect the expression patterns of TRPM2 and neutrophil cytosolic factor 1 (p47 phox), followed by evaluating the role of TRPM2 in autophagy and HBV replication and exploring the interaction between TRPM2 and p47 phox. Collaborative experiments were further designed to explore the role of p47 phox and autophagy in TRPM2 regulation of HBV replication, in addition to animal experimentation to validate the role of TRPM2/p47 phox axis in vivo. It was found that TRPM2 up‐regulation was associated with HBV replication. On the other hand, silencing of TRPM2 inhibited HBV replication and autophagy in vitro and in vivo, as evidenced by reduced HBV DNA load, HBV mRNA, HBeAg and HBsAg, and diminished autophagic spot number, LC3 II/I ratio, Beclin‐1 expressions and increased p62 expressions. Mechanistic experimentation illustrated that TRPM2 interacted with p47 phox and positively regulated p47 phox, such that p47 phox up‐regulation or use of Rapamycin (autophagy activator) weakened the inhibitory role of silencing TRPM2. Collectively, our findings indicated that HBV infection promotes TRPM2 expression, and TRPM2 interacts with p47 phox to induce autophagy and facilitate HVB replication.
Environmental risk factors for the development of oral squamous cell carcinoma in cats
Authors: Zaccone Riccardo , Renzi Andrea , Chalfon Carmit , Lenzi Jacopo , Bellei Emma , Marconato Laura , Ros Eriberta , Rigillo Antonella , Bettini Giuliano , Faroni Eugenio , Guerra Dina , Sabattini Silvia 
Published: May 2022

AbstractBackgroundRisk factors for oral squamous cell carcinoma (OSCC) in cats are derived from a single study dated almost 20 years ago. The relationship between inflammation of oral tissues and OSCC is still unclear.ObjectivesTo investigate previously proposed and novel potential risk factors for OSCC development, including oral inflammatory diseases.AnimalsHundred cats with OSCC, 70 cats with chronic gingivostomatitis (CGS), 63 cats with periodontal disease (PD), and 500 controls.MethodsProspective, observational case‐control study. Cats with OSCC were compared with an age‐matched control sample of client‐owned cats and cats with CGS or PD. Owners of cats completed an anonymous questionnaire including demographic, environmental and lifestyle information.ResultsOn multivariable logistic regression, covariates significantly associated with an increased risk of OSCC were rural environment (OR: 1.77; 95% CI: 1.03‐3.04;P = .04), outdoor access (OR: 1.68; 95% CI: 1.07‐2.63;P = .02), environmental tobacco smoke (OR: 1.77; 95% CI: 1.05‐3;P = .03), and petfood containing chemical additives (OR: 1.98; 95% CI: 1.04‐3.76;P = .04). Risk factors shared with CGS and PD were outdoor access and petfood containing chemical additives, respectively. A history of oral inflammation was reported in 35% of cats with OSCC but did not emerge as a risk factor.Conclusions and Clinical ImportanceThe study proposes novel potential risk factors for OSCC in cats. Although a history of inflammatory oral disease was not significantly more frequent compared with random age‐matched controls, OSCC shared several risk factors with CGS and PD.
Elevational patterns in tropical bryophyte diversity differ among substrates: A case study on Baru volcano, Panama
Authors: Rodríguez‐Quiel Eyvar Elías , Kluge Jürgen , Mendieta‐Leiva Glenda , Bader Maaike Y. 
Published: May 2022

AbstractQuestionsBryophytes attain their highest diversity in tropical mountain forests. Although distribution patterns have been described, little emphasis has been placed on comparing patterns among substrates (e.g., terrestrial, epiphytic). Understanding these patterns is important, because they determine not only the pool of genetic resources, but also the functioning of these forest ecosystems. Therefore, we studied how bryophyte species diversity changes with elevation, how elevational patterns differ between substrate types, and how elevational trends relate to environmental drivers.LocationBaru volcano, Panama.MethodsAt each of eight elevations, between 1900 and 3300 m, bryophytes were collected in 600‐cm2 plots from six substrate types with four replicates. Species cover was registered as a measure of relative abundance. Species richness and community structure were determined and related to elevation, substrate types, and environmental drivers at three scales (plots, sets of four replicate plots per substrate per elevation, and all plots at each elevation).ResultsBryophyte species richness decreased towards higher elevations, at all three scales and on all substrates except bryophytes on soil, for which, at the plot scale, richness peaked at higher elevations than on the other substrates. Relative humidity explained richness slightly better than elevation. Communities at the lowest elevations had the most uneven compositions, due to the presence of many small species with low abundance.ConclusionsIn studies on the spatial distribution of bryophyte diversity, it is essential to consider different substrates and spatial scales separately. If substrates differ in their elevational species richness patterns, climate and land‐use change may affect bryophyte diversity patterns not only directly, but also indirectly via changes in substrate availability. Therefore, a better understanding of the spatial variation in bryophyte diversity in mountains is essential to elucidate the effects of environmental change on this important group of plants and their implications for ecosystem functioning.
The classical SOS pathway confers natural variation of salt tolerance in maize
Authors: Zhou Xueyan , Li Jianfang , Wang Yiqiao , Liang Xiaoyan , Zhang Ming , Lu Minhui , Guo Yan , Qin Feng , Jiang Caifu 
Published: May 2022

Summary

Sodium (Na+) is the major cation damaging crops in the salinised farmland. Previous studies have shown that the Salt Overly Sensitive (SOS) pathway is important for salt tolerance in Arabidopsis. Nevertheless, the SOS pathway remains poorly investigated in most crops.

This study addresses the function of the SOS pathway and its association with the natural variation of salt tolerance in maize.

First, we showed that a naturally occurring 4‐bp frame‐shifting deletion in ZmSOS1 caused the salt hypersensitive phenotype of the maize inbred line LH65. Accordingly, mutants lacking ZmSOS1 also displayed a salt hypersensitive phenotype, due to an impaired root‐to‐rhizosphere Na+ efflux and an increased shoot Na+ concentration. We next showed that the maize SOS3/SOS2 complex (ZmCBL4/ZmCIPK24a and ZmCBL8/ZmCIPK24a) phosphorylates ZmSOS1 therefore activating its Na+‐transporting activity, with their loss‐of‐function mutants displaying salt hypersensitive phenotypes. Moreover, we observed that a LTR/Gypsy insertion decreased the expression of ZmCBL8, thereby increasing shoot Na+ concentration in natural maize population.

Taken together, our study demonstrated that the maize SOS pathway confers a conservative salt‐tolerant role, and the components of SOS pathway (ZmSOS1 and ZmCBL8) confer the natural variations of Na+ regulation and salt tolerance in maize, therefore providing important gene targets for breeding salt‐tolerant maize.
Candidate evaluation of national recruitment in oral surgery
Authors: McKernon Sarah L. , Yates Julian , Foster Martin , Blacklock Pippa , Balmer Colette , Spencer R James 
Published: May 2022

AbstractAimTo ascertain the perceptions and experiences of candidates of national recruitment and multi‐station interviews for the selection of oral surgery specialty trainees to UK during the first 3 years of being introduced.Material and methodsA pre‐piloted questionnaire was administered in paper format to applicants immediately following completion of the final recruitment day. Applicants were asked six questions regarding appropriateness of each of the stations using a Likert scales (1 strongly disagree to 5 strongly agree).ResultsDuring a 3‐year period, feedback was favourable for those stations most likely to be associated with a career in oral surgery, which was in stark contrast to the critical appraisal station which consistently received feedback regarding the time allocated to it. Survey feedback each year was presented to the working group and helped to develop and inform future stations.ConclusionsCandidates considered national recruitment to be both a fair and transparent process, which the majority supporting the move away from traditional CV‐focused interviews.
Assessing the feasibility of using autogenous maxillary bone graft to repair isolated orbital floor fractures: A pilot study using CT measurements
Authors: Yu Stephen , De Silva Harsha , Narsinh Pritesh , Marra Jamie , Fong Amy , Dias George 
Published: May 2022

AbstractIntroductionOrbital floor fractures are a common injury managed by oral maxillofacial surgeons. They can result in significant bony defects that increase the orbital volume and necessitate surgical repair to avoid the development of enophthalmos. A variety of materials have been used in the reconstruction of orbits including alloplastic materials and autogenous bone grafts. The use of the anterior maxillary antral wall as a bone graft offers the advantage of being readily accessible, naturally thin and has less donor site morbidity than other bone graft sites. There is a paucity of literature in regards to how and when to use an anterior maxillary antral wall graft.Materials and MethodsWe performed a retrospective review of computerized tomography head scans for patients presenting with isolated orbital floor fractures over a 5‐year period. 25 patients were included in the study and manual measurements were recorded for the orbital floor defect and the dimensions of the ipsilateral and contralateral anterior maxillary wall.ResultsIt was found that 92% of fractures could have been repaired using a contralateral anterior maxillary wall bone graft (p < 0.05).ConclusionUse of the anterior wall of the maxillary antrum is a feasible alternative to traditional alloplastic materials. Further study using three‐dimensional bio‐modelling could help developing more accurate guidelines for using this technique in orbital fracture repair.
Arthroscopic Modified Double‐Row Biceps Tenodesis versus Labral Repair for the Treatment of Isolated Type II SLAP Lesions in Non‐Overhead Athletes
Authors: Song Yu , Wu Zhong , Wang Miao , Liu Shengfu , Cong Ruijun , Tao Kun 
Published: May 2022

AbstractObjectiveTo evaluate the postoperative efficacy and the clinical outcomes of arthroscopic modified double‐row biceps tenodesis versus labral repair.MethodsA retrospective study was conducted in 56 patients with isolated type II superior labrum anterior and posterior (SLAP) lesions from March 2015 to November 2018. Thirty patients (male:female = 17:13) were treated with labral repair, and 26 patients (male:female = 15:11) were treated with modified double‐row biceps tenodesis. The average age of the labral repair group and the modified double‐row biceps tenodesis group were 42.8 ± 10.6 and 40.9 ± 10.2 years, respectively. Pre‐ and postoperative assessments with the visual analog scale (VAS), University of California Los Angeles (UCLA), and American Shoulder and Elbow Surgeons (ASES) scores were compared between the two treatment groups. Additional outcome measures included patient satisfaction, the time to return to previous activities, workers' compensation status, and postoperative complications.ResultsAt a 2‐year follow‐up, the tenodesis group showed significant differences in postoperative VAS (1.5 to 1.8, respectively; p = 0.008), patient satisfaction (92.3% vs. 46.7%, p < 0.001), and recovery time to return to their previous activities (6.8 ± 1.8 vs. 8.1 ± 1.5, p = 0.007) compared to the labral repair group; however, there was no significant difference in postoperative ASES and UCLA scores between the two groups. Additionally, one patient in the tenodesis group developed persistent postoperative stiffness, which was resolved by conservative treatment. In the labral repair group, two patients presented with persistent postoperative night pain, three developed persistent postoperative stiffness, and two required a subsequent capsular release.ConclusionsCompared with the labral repair group, the arthroscopic modified double‐row biceps tenodesis showed more encouraging postoperative pain reduction, earlier recovery to previous activities, and higher patient satisfaction.
Modified Chevron Osteotomy with Distal Soft Tissue Release for Treating Moderate to Severe Hallux Valgus Deformity: A Minimal Clinical Important Difference Values Study
Authors: Gong Xiao‐feng , Sun Ning , Li Heng , Li Ying , Lai Liang‐peng , Li Wen‐jing , Wang Yan , Wu Yong 
Published: May 2022

ObjectiveTo explore whether modified Chevron osteotomy together with distal soft tissue release would correct moderate to severe HV deformity and what is the minimal clinical important difference (MCID) for objective and subjective evaluating parameters.MethodsFrom March 2018 to January 2019, 40 hallux valgus patients (including moderate to severe) were enrolled in this retrospective study. The cohort included four males and 36 females. The average age at surgery was 50.95 (range 22–75) years. All patients underwent modified Chevron osteotomy together with distal soft tissue release and completed at least one follow‐up at clinic. The American Orthopaedic Foot and Ankle forefoot score (AOFAS, forefoot), Visual Analog Scale (VAS), and Foot Function Index (FFI) were all collected before and after surgery. Besides, the hallux valgus angle (HVA), 1st–2nd intermetatarsal angle (IMA) and distal metatarsal articular angle (DMAA) were measured both before surgery and at last follow‐up. All MCID values were calculated by employing distribution‐based method.ResultsThirty‐seven patients (92.5%) showed satisfied result at a mean 14.3‐month follow‐up (range 13–22 month). Two patients complained about residual pain at the bunion, and overcorrection (hallux varus) occurred in one patient. Meanwhile, no patient observed nonunion. Being female, age more than 60, residual HVA deformity (>15°), and post IMA more than 9° showed no statistical relationship with the post‐operation residual pain (P > 0.05). However, high VAS score before surgery (more than 7) showed strong correlation with residual pain (P < 0.01). The subjective MCID value was 9.50 for AOFAS, 18.92 for FFI, and 1.27 for VAS, respectively.ConclusionThe modified Chevron osteotomy together with distal soft tissue release could achieve a satisfied result for moderate to severe HV deformity at early follow‐up. The residual pain was associated with severe pain before surgery (VAS more than 7).
Characteristics of Deep Venous Thrombosis in Isolated Lower Extremity Fractures and Unsolved Problems in Guidelines: A Review of Recent Literature
Authors: Zhao Wei‐guang , Zhang Wei‐li , Zhang Ying‐ze 
Published: May 2022

AbstractDeep venous thrombosis (DVT) has been characterized by a disorder of venous return caused by abnormal blood clotting in deep veins. It often occurs in the lower limbs and is a common complication in orthopaedics. Therefore, relevant professional organizations domestic and overseas had formulated and constantly updated relevant guidelines to prevent the occurrence of DVT. According to the management strategy of the guidelines, the incidence of DVT can be significantly reduced. However, due to the variety of fractures types, the guidelines cannot expound precautions and characteristics of DVT for all fracture types at present, and there are other related unresolved problems. For example, there is still a lack of consistent optimal strategies for the management of DVT following isolated lower extremity fractures with a higher incidence. The best anticoagulant strategies for patients with upper limb fractures, pediatric fractures, and those combined with other injuries are rarely described in orthopaedic guidelines, but such fractures are common in clinical orthopaedics. The long‐term complications after DVT, such as post‐thrombotic syndrome, are not well‐understood. In the absence of clear guidance, orthopaedic surgeons often resort to empiric anticoagulation or conservative treatment, so the prevention effects of DVT are inconsistent. The purpose of this review is to summarize the characteristics of DVT events after isolated lower extremity fractures and to discuss the unsolved issues in the guidelines by reviewing the previous literature and tracing the history of DVT discovery, to provide more scientific and comprehensive recommendations for the prediction and prevention of DVT.
PUVA therapy in persistent cutaneous histiocytosis: Case report and literature review
Authors: Taibo Ana , Martin Ignacio , Almagro Manuel , Rego Isidro , Sacristan Felipe , Fonseca Eduardo 
Published: May 2022

AbstractBackgroundCutaneous and mucocutaneous histiocytosis (group C) comprise a wide variety of entities affecting skin and/or mucosae. Although they are considered as reactive proliferations, their exact pathophysiology remains unknown and, therefore, they lack a specific treatment.AimsThe aim of this study is to review the evidence on cases of histiocytosis treated with UVB and/or UVA and to report a new case of relapsing group C histiocytosis that has been successfully treated with PUVA therapy.Materials & MethodsWe have conducted a review of the literature published over the last 40 years on the treatment of histiocytosis with phototherapy in the online PubMed database. We also describe a new case of successful treatment of histiocytosis with PUVA therapy.ResultsOur patient was a 27‐year‐old man with persistent outbreaks of cutaneous histiocytosis over the previous 8 years. He responded successfully to PUVA therapy, and no relapse has been detected after one year of follow‐up.DiscussionSelf‐involution is usual in group C histiocytosis, so conservative management is usually the first approach. Relapsing cases pose a therapeutic challenge. Reported treatment options for these patients include isotretinoin, cryotherapy, immunosuppressants, low‐dose chemotherapy, CO2 laser, radiotherapy, and surgery. Phototherapy and photochemotherapy have been used in a small number of patients with considerable success. The main limitation to provide firm recommendations on histiocytosis therapy is the absence of solid evidence, as the articles published are mainly case reports with a short follow‐up. In our patient, despite the short follow‐up we have considered photochemotherapy to be effective since no spontaneous remission had been achieved in the previous 8 years.ConclusionPUVA therapy could be a safe and effective option to treat persistent cutaneous manifestations in patients with histiocytosis, although more evidence is required to support this statement.
Estimating Monthly Labour Force Figures During the COVID-19 Pandemic in the Netherlands
Authors: Brakel Jan , Souren Martijn , Krieg Sabine 
Published: May 2022

AbstractOfficial monthly statistics about the Dutch labour force are based on the Dutch Labour Force Survey (LFS). The LFS is a continuously conducted survey that is designed as a rotating panel design. Data collection among selected households is based on a mixed-mode design that uses web interviewing, telephone interviewing and face-to-face interviewing. Monthly estimates about the labour force are obtained with a structural time series model. Due to the COVID-19 pandemic, face-to-face interviewing stopped. It was anticipated that this would have a systematic effect on the outcomes of the LFS and that the lockdown at the same time affected the real monthly labour force figures. The lockdown indeed marked a sharp turning point in the evolution of the series of the monthly labour force figures and strongly increased the volatility of these series. In this paper, it is explained how Statistics Netherlands produced monthly labour force figures during the COVID-19 pandemic. It is shown how the sudden change in the mode effects, because face-to-face interviewing stopped, were separated from real period-to-period changes in the labour force figures. It is also explained how the time series model is adapted to the increased volatility in the labour force figures.
Bayesian Nonparametric Modelling of Multiple Graphs with an Application to Ethnic Metabolic Differences
Authors: Molinari Marco , Cremaschi Andrea , De Iorio Maria , Chaturvedi Nishi , Hughes Alun D. , Tillin Therese 
Published: May 2022

AbstractWe propose a novel approach to the estimation of multiple Gaussian graphical models (GGMs) to analyse patterns of association among a set of metabolites, under different conditions. Our motivating application is the SABRE (Southall And Brent REvisited) study, a triethnic cohort study conducted in the United Kingdom. Through joint modelling of pattern of association corresponding to different ethnic groups, we are able to identify potential ethnic differences in metabolite levels and associations, with the aim of gaining a better understanding of different risk of cardiometabolic disorders across ethnicities. We model the relationship between a set of metabolites and a set of covariates through a sparse seemingly unrelated regressions model and we use GGMs to represent the conditional dependence structure among metabolites. We specify a dependent generalised Dirichlet process prior on the edge inclusion probabilities to borrow strength across groups and we adopt the horseshoe prior to identify important biomarkers. Inference is performed via Markov chain Monte Carlo.