bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-world treatment and retreatment patterns and outcomes in patients with advanced or metastatic non-small cell lung cancer following nivolumab monotherapy in second line or later in France: an I-O Optimise analysis
Authors: Justeau Grégoire , Chouaid Christos , Debieuvre Didier , Audigier-Valette Clarisse , Quantin Xavier , Léna Hervé , Bosquet Lise , Girard Nicolas , Schoemaker Minouk J. , Mella Marta , Pinto Correia Bárbara , Rault Caroline , Daumont Melinda J. , Penrod John R. , Lee Adam , Pérol Maurice 
Published: February 2025

IntroductionThis study describes treatment and retreatment patterns and outcomes in patients in France following nivolumab as a second-line or later (2L+) treatment in locally advanced or metastatic non-small cell lung cancer (LAM NSCLC).Materials and methodsThis analysis included adults with tumor, node, metastasis stage IIIB–IV NSCLC (as defined in the 7th or 8th edition American Joint Committee on Cancer/Union for International Cancer Control) treated with nivolumab monotherapy in 2L+ using data from the retrospective Epidemiological-Strategy and Medical Economics Lung Cancer database. The inclusion period was from January 1, 2015, to September 30, 2020, with a follow-up until September 30, 2021. Analyses were stratified according to the duration of index nivolumab treatment and tumor programmed death ligand 1 expression levels.ResultsIn total, the study included 4,001 patients (68% male; mean age [standard deviation] at index date, 63.6 [9.7] years) with a median follow-up of 34.3 months. The median nivolumab duration was 2.5 months (interquartile range, 1.4–6.3). The median overall survival (OS) from nivolumab initiation was 10.2 months (95% confidence interval [CI], 9.6–10.8). The median real-world progression-free survival and time to treatment discontinuation or death (95% CI) were 2.2 (2.1–2.3) and 2.7 (2.5–2.8) months, respectively. In total, 2,985 (74.6%) patients discontinued index nivolumab treatment: 226 (7.6% of discontinuers) received a further immune checkpoint inhibitor (ICI; 12.3% of discontinuers receiving further systemic treatment), and 1,604 (53.7%) received chemotherapy and/or targeted therapy. The proportion of ICI-retreated patients was the highest among those with the longest index treatment duration (15.8% among discontinuers receiving ≥26 weeks’ index nivolumab). The median OS from retreatment was longer in the resumption (ICI restart without another therapy for ≥6 weeks) compared with the rechallenge (ICI restart following non-ICI therapy) patient subgroup.ConclusionFew patients with LAM NSCLC in France received ICI retreatment following index nivolumab discontinuation, but the proportion increased with a longer duration of index nivolumab.
Perioperative inflammatory index differences between pulmonary squamous cell carcinoma and adenocarcinoma and their prognostic implications
Authors: Liu Yi , Cui Songping , Wang Jing , Hu Bin , Chen Shuo 
Published: February 2025

BackgroundPerioperative inflammatory indices reflect systemic inflammatory responses and have been linked to cancer progression and prognosis. This study aims to explore the differences in perioperative inflammatory indices between lung squamous cell carcinoma (LSCC) and adenocarcinoma (LUAD) and their association with long-term outcomes.MethodsThis study included 287 lung cancer patients who underwent curative resection between June 2016 and December 2017, comprising 61 cases of LSCC and 226 cases of LUAD. Perioperative baseline information and inflammatory cell counts were collected. Patients were followed up for a median duration of 76 months, during which disease-free survival (DFS) and overall survival (OS) were recorded. Cox regression analysis was used to evaluate the prognostic significance of inflammatory factor levels.ResultsSignificant differences were observed in white blood cell count and systemic inflammation response index (SIRI) between LSCC and LUAD (P &lt; 0.05). Regression analysis identified age (OR=2.096, P=0.004), postoperative day 1 D-dimer level (OR=1.550, P&lt;0.001), and Platelet-to-lymphocyte ratio (PLR) (OR=1.901, P=0.031) as independent risk factors for perioperative venous thromboembolism (VTE). Furthermore, open surgical approach (HR=2.437, P=0.016), tumor type (LSCC; HR=2.437, P=0.016), and PLR (HR=1.534, P=0.019) were independent risk factors for DFS.ConclusionInflammatory index is key predictors of perioperative VTE and DFS in lung cancer, emphasizing their critical role in prognosis.
A novel nomogram based on complement C3 to predict the overall survival of early-stage hepatocellular carcinoma patients with microvascular invasion-positive undergoing curative resection
Authors: Xia Guoyi , Yu Zeyan , Lu Shaolong , Wang Xiaobo , Zhao Yuanquan , Chen Jie 
Published: February 2025

PurposeThis investigation aimed to create a new nomogram based on complement C3 to forecast 1-, 3-, and 5-year overall survival (OS) rates in patients with early-stage hepatocellular carcinoma (HCC) exhibiting microvascular invasion (MVI) post-curative surgery.MethodsThis study encompassed 1234 patients treated with resection at the Affiliated Cancer Hospital of Guangxi Medical University. The cohort for primary included 865 patients from December 2015 to December 2019, while the validation cohort comprised 369 patients. Follow-ups were conducted regularly until December 2024. Variables predicting survival were identified using Cox regression analyses, and based on these, a nomogram was constructed. This nomogram’s accuracy was assessed via time-dependent ROC curves, calibration curves and KM curve analyses.ResultsInvestigations identified complement C3, PT, the presence of cirrhosis, tumor capsule, and MVI-M2 as distinct predictors of survival in HCC patients. Based on these findings, a predictive nomogram was constructed and validated, aimed at estimating the 1-, 3-, and 5-year OS. The efficacy of the nomogram was validated through analyses with ROC curves, calibration curves, each demonstrating positive outcomes. Additionally, KM curve analysis effectively separated the patient populations into two prognostic risk categories within both the primary and validation cohorts.ConclusionIn conclusion, a new nomogram has been developed and corroborated through multivariate Cox regression analysis, aimed at estimating overall survival for patients in early stages of microvascular invasion following surgical resection. This tool has proven to be more effective in forecasting survival outcomes for such patients post-curative surgery.
Caregiver determinants and capacity for participation in constraint-induced movement therapy
Authors: Moore Hunter G. , Ayala Amy , Aravamuthan Bhooma R. , Smith Alyssa E. , Ramey Sharon L. , Hoyt Catherine R. 
Published: February 2025

AimHemiplegic cerebral palsy affects 1 in every 1,100 children, making it the most common pediatric motor disability. Constraint-Induced Movement Therapy (CIMT) is an evidence-based intervention that significantly improves upper extremity function when implemented with high fidelity. Despite its effectiveness, CIMT's intensive nature—requiring daily therapy for up to twenty days—limits its availability. This study examined caregivers’ perspectives on implementing and adapting home-based CIMT to identify practical solutions for improving intervention accessibility.MethodCaregivers of a child who has a diagnosis associated with upper extremity motor impairment consistent with cerebral palsy were recruited from the Cerebral Palsy Center at the St. Louis Children's Hospital. Caregivers completed a semi-structured interview to share their CIMT experiences, as well as their ideas and opinions related to modified versions of CIMT. All interviews were coded and analyzed for themes using descriptive analysis.ResultsTwelve interviews were conducted and revealed that caregivers would be interested in CIMT with an at-home model. Those who had experience with CIMT stated they found meaningful results from their participation in CIMT. Caregivers communicated potential challenges such as their child remaining engaged in at-home therapy, caregiver confidence in implementing the therapy, and the time required for implementing caregiver-led, home-based CIMT.InterpretationStudy findings identified that caregivers see value in a modified, at-home CIMT program. Developing a modified version of CIMT is needed to increase access to this beneficial intervention.
The clinical value of α-hydroxybutyrate dehydrogenase, cardiac troponin I, and B-type natriuretic peptide in perioperative diagnosis of heart failure in children with congenital heart disease
Authors: Yin Jun , Wang Qingsong , Xu Shuqiong , Wang Junru , Huang Shihua , Shen Junhong , Yuan Tao , Luo Tongyong , Wang Xianmin 
Published: February 2025

ObjectiveThis study evaluates the clinical value of α-Hydroxybutyrate Dehydrogenase (α-HBDH), Cardiac Troponin I (cTnI), and B-Type Natriuretic Peptide (BNP) in the perioperative diagnosis of heart failure in children with congenital heart disease (CHD).MethodsA retrospective analysis was performed on data from 107 children with CHD who underwent surgery between March 2022 and March 2023. Patients were categorized based on the European Society of Cardiology (ESC) cardiac function grading into three groups (Grades I–III) and further into heart failure (HF) and non-HF groups. Preoperative and postoperative levels of α-HBDH, cTnI, and BNP were compared across cardiac function grades and HF status. The diagnostic value of these biomarkers was assessed using receiver operating characteristic (ROC) curve analysis.ResultsPreoperative levels of α-HBDH, cTnI, and BNP were significantly higher in the HF group than in the non-HF group (all P &lt; 0.05). These markers also increased with cardiac function severity, being highest in Grade III. Postoperatively, α-HBDH, CKMB, and BNP remained elevated in severe cases, correlating with worsening function (all P &lt; 0.05). The ROC analysis showed that among the preoperative cardiac biomarkers in children with CHD, whether assessed individually or in combination, the combined detection of cTnI and BNP exhibited the highest diagnostic value for perioperative heart failure, with an AUC of 0.883.ConclusionIn children with CHD, preoperative levels of α-HBDH, cTnI, and BNP during the perioperative period are closely correlated with cardiac function, significantly increasing with the severity of cardiac dysfunction. These biomarkers have important clinical value for diagnosing heart failure, with the combined detection of cTnI and BNP demonstrating the highest diagnostic efficacy.
Perioperative comparison of whether the liver was lifted out of the abdominal cavity in Kasai surgery
Authors: Xu Ke , Gao Juan , Chen Xiaoyi , Fang Yifan , Wu Dianming , Lin Yu 
Published: February 2025

ObjectiveTo compare the perioperative effect of whether the liver is lifted out of the abdominal cavity during Kasai surgery in patients with biliary atresia type III.MethodsWe retrospectively analyzed 29 males and 33 females aged 2.2 ± 0.6 months who underwent kasai surgery from June 2019 to December 2022 at Fujian Provincial Children's Hospital. Among the 62 children with the liver not lifted out of the abdominal cavity into the experimental group (n = 31), and those with the liver lifted out of the abdominal cavity into the control group (n = 31). We compared the operation time, surgical incision length, intraoperative blood pressure and body temperature fluctuations, average daily peritoneal drainage, postoperative length of hospital stay, postoperative complications, postoperative total bilirubin level, and autologous liver survival rate between the two groups.ResultsThe length of the surgical incision in the control group (7.5 ± 1.2 cm) was longer than that in the experimental group (6.7 ± 1.1 cm), and the difference was statistically significant (t = 2.88, P = 0.005). The fluctuations in blood pressure in the control group (before and after the liver was lifted out of the abdominal cavity) (24.3 ± 7.7 mmHg) were greater than that in the experimental group (before and after hooking to expose the hilar area) (20.2 ± 6.0 mmHg), which was a statistically significant difference (t = 2.32, P = 0.023). The temperature fluctuations in the control group (before and after the liver was lifted out of the abdominal cavity) (0.3 ± 0.1°C) was greater than that in the experimental group (before and after the liver was lifted out of the abdominal cavity) (0.1 ± 0.1°C), showing a statistically significant difference (t = 8.19, P = 0.000). The average daily abdominal drainage in the control group was 71.3 ± 33.5 ml, which was greater than that in the experimental group (49.2 ± 49.6 ml), and the difference was statistically significant (t = 2.06, P = 0.044). The number of days of postoperative hospital stay in the control group (18.2 ± 4.8 days) was significantly more than that in the experimental group (15.8 ± 3.8 days), with a statistically significant difference (t = 2.18, P = 0.033).ConclusionIn children with biliary atresia type III, the liver is not lifted out of the abdominal cavity during Kasai surgery increases the safety of surgery and reduces the length of hospital stay.
Disitamab vedotin combined with pyrotinib as salvage treatment in Her-2-amplified treatment refractory metastatic colorectal cancer: a case report
Authors: Chen Jianxin , Wang Jian , Zheng Qinhong 
Published: February 2025

BackgroundHuman epidermal growth factor receptor 2 (HER-2) amplification has been identified in approximately 3% of patients with metastatic colorectal cancer (mCRC). Owing to the lack of established anti-ERBB2 therapeutic approaches, mCRC patients with Her-2 amplification rarely receive targeted treatments. Moreover, conventional chemotherapy regimens are not ideal for these patients, leaving options in the advanced stage limited to best supportive care or participation in clinical drug trials.Case presentationThis report presents a case of a patient with Her-2-amplified refractory mCRC treated with a salvage regimen combining Disitamab Vedotin and Pyrotinib, resulting in a partial response and progression-free survival for 6 months, which is still ongoing.ConclusionThis case study suggests that the anti-Her-2 regimen involving Disitamab Vedotin and Pyrotinib may offer a potential salvage treatment option for patients with Her-2-amplified mCRC patients. However, further validation in larger cohorts is necessary in future studies.
Effect of hypoalbuminemia on drug pharmacokinetics
Authors: Idasiak-Piechocka Ilona , Lewandowski Dominik , Świgut Wojciech , Kalinowski Jan , Mikosza Klaudia , Suchowiejski Piotr , Szałek Edyta , Karbownik Agnieszka , Miedziaszczyk Miłosz 
Published: February 2025

Hypoalbuminemia, defined as serum albumin levels below 35 g/L, is common in patients with conditions such as nephrotic syndrome, cirrhosis, or sepsis. This review examines the impact of hypoalbuminemia on the pharmacokinetics of selected drugs—such as antibiotics, immunosuppressants, antifungals, or anticonvulsants—emphasizing its role in drug efficacy and safety. Albumin is the main drug transporter and key binding protein, which influences the free drug concentration and drug activity. The review includes all studies available in the scientific literature found in the PubMed, Scopus, and Cochrane databases. The paper emphasizes the importance of therapeutic drug monitoring (TDM) in patients with hypoalbuminemia to avoid subtherapeutic or toxic drug levels. Many drugs need for dose adjustments to achieve therapeutic levels, especially in critically ill patients. The results of studies emphasize the need for individualized dosing regimens based on TDM to optimize drug therapy in patients with hypoalbuminemia. Our review is the first article to summarize the influence of hypoalbuminemia on the pharmacokinetic parameters of drugs and may be a useful tool for clinicians in their daily work.
Duration-dependent physiological, perceptual, and technical changes during a 2-hour low-intensity training session in female cross-country skiers
Authors: Torvik Per-Øyvind , Solli Guro Strøm , Talsnes Rune Kjøsen , Sandbakk Øyvind 
Published: February 2025

PurposeThis study investigated duration-dependent physiological, perceptual, and technical changes during a 2-hour low-intensity training (LIT) session in female cross-country (XC) skiers.MethodsTwelve national-level female XC skiers (age:21.4 ± 2.7 years, maximal oxygen uptake: 58.1 ± 5.3 mL min⁻1·kg⁻1) performed a 2-hour LIT session, roller-ski skating in the laboratory while alternating between two main sub-techniques (Gear-2 and Gear-3). Acute physiological and perceptual responses, including oxygen uptake, carbon dioxide production, ventilation, breathing frequency, respiratory exchange ratio, blood lactate concentration, and rate of perceived exertion, as well as kinematic variables (cycle length and cycle rate), were collected at four consecutive timepoints (T1–T4) for both sub-techniques. A post-session questionnaire collected data on perceived total, ventilatory, and mental exertion as well as perceived training quality.ResultsRelatively small duration-dependent changes were observed for most of the physiological measures. The most pronounced changes were a main effect of time on breathing frequency (BF; F (3,30) = 3.52, ηp2 = 0.260, P = 0.027) and rate of perceived exertion (RPE; F (3, 33) = 4.43, ηp2 = 0.287, P = 0.010). More specifically, BF was higher in Gear-3 at both T2 (45.5 ± 7.7 breaths·min-1) and T3 (45.5 ± 7.7), compared to T1 (43.2 ± 7.3, all P &lt; 0.05). Furthermore, the rate of perceived exertion was higher in both Gear-2 and Gear-3 at T2 (G2: 12.1 ± 1.0, G3: 11.2 ± 1.6) and T3 (G2: 12.2 ± 1.1, G3: 11.2 ± 1.6), compared to T1 (G2: 11.5 ± 1.2, G3: 10.6 ± 1.2, all P &lt; 0.05). No differences were observed in kinematic variables (cycle length and cycle rate) between T1 - T4. Lastly, no differences in perceived total, ventilatory, and mental exertion, as well as perceived training quality, were observed between the first and second half of the LIT session.ConclusionWell-trained female XC skiers performed a 2-hour LIT session while roller-ski skating in the laboratory with relatively small duration-dependent physiological, perceptual, and technical changes.
Predicting climate-driven shift of the East Mediterranean endemic Cynara cornigera Lindl
Authors: Bedair Heba , Hazzazi Yehia , Abo Hatab Asmaa , Halmy Marwa Waseem A. , Dakhil Mohammed A. , Alghariani Mubaraka S. , Sumayli Mari , El-Shabasy A. , El-Khalafy Mohamed M. 
Published: February 2025

IntroductionClimate change poses significant challenges to the distribution of endemics in the Mediterranean region. Assessing the impact of climate change on the distribution patterns of Mediterranean endemics is of critical importance for understanding the dynamics of these terrestrial ecosystems under the uncertainty of future changes. The population size of the Cynara cornigera has declined significantly over the previous century across its geographical region. This decline is linked to how ongoing climate change is affecting natural resources like water and the capacity of foraging sites. In fact, it is distributed in 3 fragmented locations in Egypt (Wadi Hashem (5 individuals), Wadi Um Rakham (20 individuals), Burg El-Arab (4 individuals)).MethodsIn this study, we examined C. cornigera’s response to predicted climate change over the next few decades (2020-2040 and 2061-2080) using species distribution models (SDMs). Our analysis involved inclusion of bioclimatic variables, in the SDM modeling process that incorporated five algorithms: generalized linear model (GLM), Random Forest (RF), Boosted Regression Trees (BRT), Support Vector Machines (SVM), and Generalized Additive Model (GAM).Results and discussionThe ensemble model obtained high accuracy and performance model outcomes with a mean AUC of 0.95 and TSS of 0.85 for the overall model. Notably, RF and GLM algorithms outperformed the other algorithms, underscoring their efficacy in predicting the distribution of endemics in the Mediterranean region. Analysis of the relative importance of bioclimatic variables revealed Precipitation of wettest month (Bio13) (88.3%), Precipitation of warmest quarter (Bio18) (30%), and Precipitation of driest month (Bio14) (22%) as the primary drivers shaping the potential distribution of C. cornigera. The findings revealed spatial variations in habitat suitability, with the highest potential distribution observed in Egypt, (especially the Arishian sub sector), Palestine, Morocco, Northern Cyprus, and different islands in the Sea of Crete. Furthermore, our models predicted that the distribution range of C. cornigera would drop by more than 25% during the next few decades. Surprisingly, the future potential distribution area of C. cornigera (SSP 126 scenario) for 2061 and 2080 showed that there is increase in the suitable habitats area. It showed high habitat suitability along the Mediterranean coastal strip of Spain, Sardinia, Morocco, Algeria, Tunisia, Libya, Egypt, (especially the Arishian sub sector), Palestine, Lebanon, Northern Cyprus, and different Aegean islands.
Exploring marriage beliefs from the perspectives of married students
Authors: Sadeghian Efat , Ghasemi Seyed Ali , Maddineshat Maryam 
Published: February 2025

IntroductionIranian university students have a positive outlook on marriage; however, certain beliefs may impact their satisfaction with marriage and the quality of their relationships. By examining these beliefs and considering the experiences of married students, valuable information can be gathered to develop policies that protect family rights and support the younger generation.AimThis study aimed to explore the beliefs about marriage from the perspectives of married students.MethodA qualitative study was conducted. University students were selected through purposive sampling at Hamadan University Medical Sciences,…, Iran. Data was collected from October 2022 to January 2023. Semi-structured interviews were held with 24 married students, and the analysis was conducted using conventional content analysis.ResultsIn our research, we thoroughly analyzed 51 beliefs about marriage held by students, categorizing them into eight subcategories, including “empathy and simplifying life,” “keeping affection alive,” “effective and transparent communication,” and others. These beliefs were further condensed into three overarching categories: “intimacy and companionship,” “establishing a secure environment,” and “equity and upholding preexisting convictions.”ConclusionThe research explored the intricate interplay of beliefs shaping university students' beliefs toward marriage. Beliefs surrounding empathy, simplifying life, sustaining affection, and effective and transparent communication contribute to marriage intimacy and compassion. Notably, beliefs concerning security, commitment, and conflict resolution strategies were identified as pivotal for creating a safe marital atmosphere. Furthermore, the presence of beliefs supporting women's autonomy was deemed crucial for fostering equality within marital partnerships, while beliefs endorsing male dominance, religious biases, sexism, and cultural bigotries were found to impact spousal relationships potentially detrimentally.