bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral Language and Emergent Literacy Strategies Used by Australian Early Childhood Teachers During Shared Book Reading
Authors: Weadman Tessa , Serry Tanya , Snow Pamela C. 
Published: August 2022

AbstractThe use of shared book reading is regarded as valuable to support young children to build their oral language and emergent literacy skills in preschool classrooms. Quantitative and qualitative features of early childhood teachers’ (ECTs’) shared book reading practices are important contributors to quality shared book reading experiences. The aim of this study was to gain in-depth insights about the range and frequency of extratextual oral language and emergent literacy utterances (utterances beyond the story text) used by ECTs during shared book reading with preschoolers as well as their use of paralinguistic and nonverbal features. Video-recordings were made of 32 ECTs engaging in shared book reading with their four-year-old preschool class. ECTs’ extratextual utterances and their paralinguistic and nonverbal features were classified using a validated observational checklist: The “Emergent Literacy and Language Early Childhood Checklist for Teachers” (ELLECCT). Results showed ECTs frequently used responsive statements such as commenting on the story or acknowledging or imitating children’s utterances in book-related talk. ECTs most commonly asked closed questions during shared book reading and regularly used paralinguistic and nonverbal features such as prosody and volume in order to engage children. In contrast, ECTs used only a limited range of dialogic reading prompts and explicit vocabulary strategies and only infrequently expanded children’s utterances. Notably, ECTs rarely used strategies to target children’s print knowledge or phonological awareness. Although extratextual dialogue was used regularly by ECTs during shared book reading, targeted techniques that are known to build oral language and emergent literacy were not consistently demonstrated. These results suggest missed opportunities for preschool children to benefit from shared book reading.
Joint modelling of audio-visual cues using attention mechanisms for emotion recognition
Authors: Ghaleb Esam , Niehues Jan , Asteriadis Stylianos 
Published: August 2022

AbstractEmotions play a crucial role in human-human communications with complex socio-psychological nature. In order to enhance emotion communication in human-computer interaction, this paper studies emotion recognition from audio and visual signals in video clips, utilizing facial expressions and vocal utterances. Thereby, the study aims to exploit temporal information of audio-visual cues and detect their informative time segments. Attention mechanisms are used to exploit the importance of each modality over time. We propose a novel framework that consists of bi-modal time windows spanning short video clips labeled with discrete emotions. The framework employs two networks, with each one being dedicated to one modality. As input to a modality-specific network, we consider a time-dependent signal deriving from the embeddings of the video and audio modalities. We employ the encoder part of the Transformer on the visual embeddings and another one on the audio embeddings. The research in this paper introduces detailed studies and meta-analysis findings, linking the outputs of our proposition to research from psychology. Specifically, it presents a framework to understand underlying principles of emotion recognition as functions of three separate setups in terms of modalities: audio only, video only, and the fusion of audio and video. Experimental results on two datasets show that the proposed framework achieves improved accuracy in emotion recognition, compared to state-of-the-art techniques and baseline methods not using attention mechanisms. The proposed method improves the results over baseline methods by at least 5.4%. Our experiments show that attention mechanisms reduce the gap between the entropies of unimodal predictions, which increases the bimodal predictions’ certainty and, therefore, improves the bimodal recognition rates. Furthermore, evaluations with noisy data in different scenarios are presented during the training and testing processes to check the framework’s consistency and the attention mechanism’s behavior. The results demonstrate that attention mechanisms increase the framework’s robustness when exposed to similar conditions during the training and the testing phases. Finally, we present comprehensive evaluations of emotion recognition as a function of time. The study shows that the middle time segments of a video clip are essential in the case of using audio modality. However, in the case of video modality, the importance of time windows is distributed equally.
Distribution Patterns of Astrocyte Populations in the Human Cortex
Authors: Forrest Shelley L. , Kim Jordan Hanxi , Crockford Daniel R. , Huynh Katharine , Cheong Rosie , Knott Samantha , Kane Madison A. , Ittner Lars M. , Halliday Glenda M. , Kril Jillian J. 
Published: August 2022

AbstractAstrocytes are a major class of glial cell in the central nervous system that have a diverse range of types and functions thought to be based on their anatomical location, morphology and cellular properties. Recent studies highlight that astrocyte dysfunction contributes to the pathogenesis of neurological conditions. However, few studies have described the pattern, distribution and density of astrocytes in the adult human cortex. This study mapped the distribution and density of astrocytes immunolabelled with a range of cytoskeletal and membrane markers in the human frontal cortex. Distinct and overlapping astrocyte populations were determined. The frontal cortex from ten normal control cases (75 ± 9 years) was immunostained with glial fibrillary acidic protein (GFAP), aldehyde dehydrogenase-1 L1 (ALDH1L1), connexin-43 (Cx43), aquaporin-4 (AQP4), and glutamate transporter 1 (GLT-1). All markers labelled populations of astrocytes in the grey and white matter, separate cortical layers, subpial and perivascular regions. All markers were informative for labelling different cellular properties and cellular compartments of astrocytes. ALDH1L1 labelled the largest population of astrocytes, and Cx43-immunopositive astrocytes were found in all cortical layers. AQP4 and GLT-1 labelled distal astrocytic process and end-feet in the same population of astrocytes (98% of GLT-1-immunopositive astrocytes contained AQP4). In contrast, GFAP, the most widely used marker, predominantly labelled astrocytes in superficial cortical layers. This study highlights the diversity of astrocytes in the human cortex, providing a reference map of the distribution of distinct and overlapping astrocyte populations which can be used for comparative purposes in various disease, inflammatory and injury states involving astrocytes.
Latency and Crisis: Mutual Aid Activism in the Covid-19 Pandemic
Authors: Ferrari Elisabetta 
Published: August 2022

AbstractActivists have responded to the Covid-19 pandemic by organizing for mutual aid: creating collective action to meet people’s material needs and build ties of solidarity. I examine the difficulties encountered by mutual aid activists during the pandemic through Alberto Melucci’s notions of latency and collective identity. Through digital ethnographic observations of the Instagram accounts of mutual aid groups based in Philadelphia, USA, as well as interviews with the activists, I explore how mutual aid, conceptualized as latency work, was practiced by activists in the unprecedented conditions of the pandemic and how activists approached collective identity processes. I show that activists experienced a compression of latency and mobilization within the crisis context of the pandemic, which made it more difficult for them to pursue the construction of a collective identity. I also suggest that the effects of this compression were further exacerbated by the logic of immediacy that characterizes social network sites.
Practical issues to consider when working with big data
Authors: Stice-Lawrence Lorien 
Published: August 2022

AbstractIncreasing access to alternative or “big data” sources has given rise to an explosion in the use of these data in economics-based research. However, in our enthusiasm to use the newest and greatest data, we as researchers may jump to use big data sources before thoroughly considering the costs and benefits of a particular dataset. This article highlights four practical issues that researchers should consider before working with a given source of big data. First, big data may not be conceptually different from traditional data. Second, big data may only be available for a limited sample of individuals, especially when aggregated to the unit of interest. Third, the sheer volume of data coupled with high levels of noise can make big data costly to process while still producing measures with low construct validity. Last, papers using big data may focus on the novelty of the data at the expense of the research question. I urge researchers, in particular PhD students, to carefully consider these issues before investing time and resources into acquiring and using big data.
Preliminary Laboratory Investigations into Zinc and Copper Adsorption by Crushed Bivalve Shells
Authors: Thind Jaspreet , McDougall Daniel R. , Jones Mark I. , Jeffs Andrew G. 
Published: August 2022

AbstractCrushed shells from three bivalve mollusc species (mussel, oyster and scallop) in two particle size ranges (63–150 μm and 710–1180 μm) were tested for their ability to remove dissolved copper and zinc ions from synthetic stormwater in a column. For comparison, zeolite (1–2 mm), which is commonly used for heavy metal ion capture, was also assessed. All shell types of both particle sizes were effective in removing zinc from solution with 97–100% removal efficiency which was similar to the removal efficiency by zeolite (97.6%). The removal of copper was most efficiently achieved with oyster shell with a particle size range of 710–1180 μm (83.6%), which was similar to the removal efficiency by zeolite (83.4%). Brunauear-Emmett-Teller (BET) surface area measurements showed significant decreases in the surface area of the shells after exposure to synthetic stormwater due to adsorption of heavy metals, visually confirmed by observation of a fine layer of metal precipitate adsorbed to the shell particle surfaces using Scanning Electron Microscopy (SEM). Overall, the results indicate that crushed bivalve shells have excellent potential for the removal of dissolved zinc and copper from stormwater and should be tested in more complex stormwater studies. This work has significant implications for stormwater infrastructure design using a local, cheap and readily accessible waste material.
Modelling acute myeloid leukemia (AML): What’s new? A transition from the classical to the modern
Authors: Dozzo Annachiara , Galvin Aoife , Shin Jae-Won , Scalia Santo , O’Driscoll Caitriona M. , Ryan Katie B. 
Published: August 2022

AbstractAcute myeloid leukemia (AML) is a heterogeneous malignancy affecting myeloid cells in the bone marrow (BM) but can spread giving rise to impaired hematopoiesis. AML incidence increases with age and is associated with poor prognostic outcomes. There has been a disconnect between the success of novel drug compounds observed in preclinical studies of hematological malignancy and less than exceptional therapeutic responses in clinical trials. This review aims to provide a state-of-the-art overview on the different preclinical models of AML available to expand insights into disease pathology and as preclinical screening tools. Deciphering the complex physiological and pathological processes and developing predictive preclinical models are key to understanding disease progression and fundamental in the development and testing of new effective drug treatments. Standard scaffold-free suspension models fail to recapitulate the complex environment where AML occurs. To this end, we review advances in scaffold/matrix-based 3D models and outline the most recent advances in on-chip technology. We also provide an overview of clinically relevant animal models and review the expanding use of patient-derived samples, which offer the prospect to create more “patient specific” screening tools either in the guise of 3D matrix models, microphysiological “organ-on-chip” tools or xenograft models and discuss representative examples.
Graphical abstract
Activation of the HSP27-AKT axis contributes to gefitinib resistance in non-small cell lung cancer cells independent of EGFR mutations
Authors: Choi Seul-Ki , Kim Minsuh , Lee Haeseung , Kwon Youngjoo , Cha Hyuk-Jin , Jang Se Jin , Na Younghwa , Lee Yun-Sil 
Published: August 2022

Abstract
Purpose
Although epidermal growth factor receptor (EGFR)-activating mutations in non-small cell lung cancer (NSCLC) usually show sensitivity to first-generation EGFR-tyrosine kinase inhibitors (TKIs), most patients relapse because of drug resistance. Heat shock protein 27 (HSP27) has been reported to be involved in the resistance of EGFR-TKIs, although the underlying mechanism is unclear. Here, we explore the mechanisms of HSP27-mediated EGFR TKI resistance and propose novel therapeutic strategies.

Methods
To determine the mechanism of HSP27 associated gefitinib resistance, differences were assessed using gefitinib-sensitive and -resistant NSCLC cell lines. In vivo xenograft experiments were conducted to elucidate the combinatorial effects of J2, a small molecule HSP27 inhibitor, and gefitinib. Analyses of human NSCLC tissues and PDX tissues were also used for comparison of HSP27 and phosphorylated AKT expression.

Results
Large-scale cohort analysis of NSCLC cases revealed that HSP27 expression correlated well with the incidence of EGFR mutations and affected patient survival. Increased pAKT and HSP27 was observed in gefitinib-resistant cells compared with gefitinib-sensitive cells. Moreover, increased phosphorylation of HSP27 by gefitinib augmented its protein stability and potentiated its binding activity with pAKT, which resulted in increased gefitinib resistance. However, in gefitinib-sensitive cells, stronger binding activity between EGFR and HSP27 was observed. Moreover, these phenomena occurred regardless of EGFR mutation including secondary mutations, such as T790M. AKT knockdown switched HSP27-pAKT binding to HSP27-EGFR, which promoted gefitinib sensitivity in gefitinib-resistant cells. Functional inhibition of HSP27 yielded sensitization to gefitinib in gefitinib-resistant cells by inhibiting the interaction between HSP27 and pAKT.

Conclusions
Our results indicate that combination of EGFR-TKIs with HSP27 inhibitors may represent a good strategy to overcome resistance to EGFR-TKIs, especially in cancers exhibiting AKT pathway activation.
Current knowledge on practices targeting soil fertility and agricultural land rehabilitation in the Sahel. A review
Authors: Nord Alison , Snapp Sieglinde , Traore Bouba 
Published: August 2022

AbstractImplementing sustainable production practices to rehabilitate soils is a grand challenge of our day, particularly for resource-poor farmers. The West African Sahel requires attention to balancing the need for increasing agricultural production against harsh environmental conditions. While there is much research documenting technologies for soil regeneration in the Sahel, there has been limited focus on how agricultural practices contribute or exacerbate these efforts. Previous assessments of agricultural practices in this region have been largely descriptive, and some soil ameliorating practices have been promoted with little empirical evidence on their effectiveness. Here we systematically review the literature on soil fertility and conservation practices that have been studied within West African Sahelian agricultural systems. We identified practices in the West African Sahel that have been tested to improve soil fertility and reduce land degradation, and summarized the outcomes of these practices. A unique contribution of this review is the assessment of site-specific conditions and contexts under which practices are most effective in studies which recorded these specific characteristics. We found that research in this area is dominated by chemical fertilizer and organic amendment practices, with moderate to few studies focused on soil and water conservation, crop diversification, or agroforestry. Additionally, most studies consisted of single practices rather than combining practices that target the range of biophysical limitations farmers face in agricultural production. These limitations highlight the need for increased research testing combinations of practices across long-term on-farm studies to generate stronger evidence of conditions under which practices best perform. These findings provide key lessons for research and extension on sustainable agricultural management under the challenging conditions of the Sahel.
Radical support for multigraded ideals
Authors: Conca A. , De Negri E. , Gorla E. 
Published: August 2022

AbstractCan one tell if an ideal is radical just by looking at the degrees of the generators? In general, this is hopeless. However, there are special collections of degrees in multigraded polynomial rings, with the property that any multigraded ideal generated by elements of those degrees is radical. We call such a collection of degrees a radical support. In this paper, we give a combinatorial characterization of radical supports. Our characterization is in terms of properties of cycles in an associated labelled graph. We also show that the notion of radical support is closely related to that of Cartwright-Sturmfels ideals. In fact, any ideal generated by multigraded generators whose multidegrees form a radical support is a Cartwright-Sturmfels ideal. Conversely, a collection of degrees such that any multigraded ideal generated by elements of those degrees is Cartwright-Sturmfels is a radical support.
Campaign Disaster Response – What Makes It Different
Authors: Zeitz Kathryn , Kay Rachael , Naughton David , Bennett Scott , Bolton Shane 
Published: August 2022

Abstract

Objective:
The coronavirus disease 2019 (COVID-19) pandemic has seen health systems adapt and change in response to local and international experiences. This study describes the experiences and learnings by the Central Adelaide Local Health Network (CALHN) in managing a campaign style, novel public health disaster response.

Methods:
Disaster preparedness has focused on acute impact, mass casualty incidents. In early 2020, CALHNs largest hospital the Royal Adelaide Hospital (RAH) was appointed as the state primary COVID-19 adult receiving hospital. Between the period of February 1, 2020, when the first COVID-19 positive patient was admitted, through to December 31, 2020, the RAH had admitted 146 inpatients with COVID-19, 118 admitted to our hospital in the home service, 18 patients admitted to Intensive Care, and 4 patients died while inpatients. During this time CALHN has sustained an active (physical and virtual) Network Incident Command Centre (NICC) supported by a Network Incident Management Team (NIMT).

Results:
This study describes our key lessons learnt in relation to the management of a campaign style disaster response including the importance of disaster preparedness, fatigue management, and communication. Also described, were the challenges of operating in a command model and the role of exercising and education and an overview of our operating rhythm, how we built capability, and lessons management.

Conclusions:
Undertaking a longer duration disaster response, relating to the COVID-19 pandemic has shown that, although traditional disaster principles still are important, there are many nuances that need to be considered to retain a proportionate response. Our key lessons have revolved around the key tenants of disaster management, communication, capability, and governance.
Forty-five terawatt vortex ultrashort laser pulses from a chirped-pulse amplification system
Authors: Chen Zhenkuan , Zheng Shuiqin , Lu Xiaoming , Wang Xinliang , Cai Yi , Wang Congying , Zheng Maijie , Ai Yuexia , Leng Yuxin , Xu Shixiang , Fan Dianyuan 
Published: August 2022

AbstractWe report on a vortex laser chirped-pulse amplification (CPA) system that delivers pulses with a peak power of 45 TW. A focused intensity exceeding 1019W/cm2has been demonstrated for the first time by the vortex amplification scheme. Compared with other schemes of strong-field vortex generation with high energy flux but narrowband vortex-converting elements at the end of the laser, an important advantage of our scheme is that we can use a broadband but size-limited q-plate to realize broadband mode-converting in the front end of the CPA system, and achieve high-power amplification with a series of amplifiers. This method is low cost and can be easily implemented in an existing laser system. The results have verified the feasibility to obtain terawatt and even petawatt vortex laser amplification by a CPA system, which has important potential applications in strong-field laser physics, for example, generation of vortex particle beams with orbital angular momentum, fast ignition for inertial confinement fusion and simulation of the extreme astrophysical environment.
Maritime glacier retreat and terminus area change in Kenai Fjords National Park, Alaska, between 1984 and 2021
Authors: Black Taryn , Kurtz Deborah 
Published: August 2022

AbstractGlacier change in Kenai Fjords National Park in southcentral Alaska affects local terrestrial, fresh water and marine ecosystems and will likely impact ecotourism. We used Landsat 4–8 imagery from 1984 through 2021 to manually map lower glacier ice margins for 19 maritime glaciers in Kenai Fjords National Park. Of these glaciers, six are tidewater, three are lake-terminating, six are land-terminating and four terminated in more than one environment throughout the study period. We used the mapped ice margins to quantify seasonal terminus position and areal change, including distinguishing between ice loss at glacier termini and along glacier margins. Overall, 13 glaciers substantially retreated (more than 2σ), 14 lost substantial area and only two underwent both net advance and area gain. The glaciers that had insubstantial length and area changes were predominantly tidewater. Cumulatively, the lower reaches of these 19 glaciers lost 42 km2 of ice, which was nearly evenly distributed between the terminus and the lateral margins. The rapid rate of glacier change and subsequent land cover changes are highly visible to visitors and locals at Kenai Fjords National Park, and this study quantifies those changes in terms of glacier length and area.
Compulsory licensing: an effective tool for securing access to Covid-19 vaccines for developing states?
Authors: Davies Lowri 
Published: August 2022

AbstractA significant issue in combatting the Covid-19 pandemic is the need to enhance developing states’ access to Covid-19 vaccines. The present paper considers the request for a temporary waiver of intellectual property rights in relation to Covid-19 technologies and treatments submitted to the World Trade Organization and analyses a key argument against the proposed waiver: that the compulsory licensing provisions set out in the TRIPS Agreement are sufficiently flexible to help states get access to vaccines. The compulsory licensing flexibilities set out in TRIPS, including the amendment to TRIPS in Article 31bis, are evaluated, to explore whether compulsory licensing could be an effective tool in helping developing states to access Covid-19 vaccines. Key issues are explored from a human rights perspective to examine whether a rights-based approach to the compulsory licensing provisions could offer further insights as to how the provisions could be more workable, to enhance access to medicines and vaccines for developing states.