bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of local pain on balance control in patients with chronic ankle instability
Authors: Chen Yungu , Cao Shengxuan , Qian Lewen , Chen Wenming , Wang Chen , Ma Xin , Wang Xu , Huang Jiazhang 
Published: July 2022

Abstract
Background
Local pain around the ankle joint is a common symptom in patients with chronic ankle instability (CAI). However, whether the local pain would impose any influence on the balance control performance of CAI patients is still unknown.

Methods
A total of twenty-six subjects were recruited and divided into the following two groups: pain-free CAI (group A) and pain-present CAI (group B). Subjects in both groups received two independent tests: the star excursion balance test and the single-leg stance test, in order to reflect their balance control ability more accurately.

Results
Compared with group A, the group B showed significantly more episodes of the history of sprains, decreased ankle maximum plantarflexion angle, and lower Cumberland scores (all p < 0.05). In the star excursion balance test, group B demonstrated a significantly reduced anterior reach distance than group A (p < 0.05). During the single leg stance test, group B showed a significant increase in the magnitude of electromyographic signals both in peroneus longus and soleus muscles than group A (each p < 0.05). Additionally, group B had a significantly more anterolaterally positioned plantar center of pressure than group A (p < 0.05).

Conclusion
CAI patients with local pain around the ankle joint had more episodes of sprains and lower functional scores when compared to those without pain. The balance control performance was also worse in the pain-present CAI patients than those without pain.
Shaping outcome of ProTaper NEXT for root canal preparation in mandibular incisors: a micro-CT study
Authors: Wang Hao , Yang Xueqin , Zou Ling , Huang Dingming , Zhou Xuedong , Xu Jialei , Gao Yuan 
Published: July 2022

Abstract
Background
Relatively high incidence of single canals with oval or round shape were observed in human mandibular incisors. In order to investigate the influence of the root canal morphology on root canal preparation, the shaping outcome of ProTaper NEXT in oval and round canals of mandibular incisors were evaluated by using micro-computed tomography (micro-CT) analysis.

Methods
This experiment was approved by the School Medical Ethics Committee. The sample size calculation was conducted using G*Power software. Intact mandibular incisors with a single canal were selected. Oval canals (2 < aspect ratio (AR) ≤ 4) and round canals (AR ≤ 2) were pair-matched according to canal length, and assigned to two experimental groups (13 per group). ProTaper NEXT was used for root canal preparation for both groups. Untouched canal wall (UCW), root canal morphological parameters and three-dimensional (3D) dentin thickness were evaluated in the entire root canal and each canal third after micro-CT scanning. Statistical analysis: Data were collected and analyzed with Mann–Whitney test and Friedman test using SPSS statistics software 25 (P < 0.05). Additionally, correlations of UCW area with canal morphological parameters were also investigated.

Results
After root canal preparation, no significant difference was observed in all analyzed parameters in the apical third between oval and round canal groups (P > 0.05). In the coronal two thirds of the canal, the post-operative structure model index (SMI), form factor and roundness were significantly increased, while the AR was significantly decreased in both groups (P < 0.05). In addition, in the coronal two thirds, significantly more UCW and higher UCWΔ% was observed in oval canal group (P < 0.05). Furthermore, UCW correlated very strongly to canal major diameter (0.924) and initial volume (0.938), and strongly to canal form factor (− 0.724), minor diameter (0.799) and canal area (0.882). Proximal dentin wall was associated with significantly thinner pre-operative dentin thickness and higher amount of dentin removal after root canal preparation in both oval and round canal groups.

Conclusions
(1) Both types of canals were more conical after root canal preparation, but oval root canals tend to leave more UCW area than round canals in the coronal two thirds of mandibular incisors, which contributes to the challenge for endodontic infection control. (2) Root canal preparation usually results in excessive dentin removal in the proximal dentin wall comparing with buccal and lingual walls in both types of canals of mandibular incisors.
Objective understanding of front of pack warning labels among Mexican children of public elementary schools. A randomized experiment
Authors: Contreras-Manzano Alejandra , Jáuregui Alejandra , Vargas-Meza Jorge , Nieto Claudia , Granich-Armenta Adriana , de Lourdes Alemán Escobar María , G.-Olvera Armando , Cruz-Casarrubias Carlos , Munguía Ana , Barquera Simón 
Published: July 2022

AbstractBackgroundWarning Labels (WL) highlight excessive amounts of critical nutrients in order to discourage consumption of unhealthful packaged food products. This study aimed to evaluate among Mexican school children, the objective understanding of traditional and numeric WL (aimed at small products) considered by the Mexican regulation, and whether cartoon characters influenced the understanding of WL. We also tested some communication strategies to facilitate the correct use of the WL.MethodsWe carried out a randomized experiment in July 2019 in public elementary schools from Morelos, Mexico. Participants aged 6–13 years, were randomly assigned to one of four groups: 1) Nutrient Facts Panel (NF) (n = 120), 2) Nutrient Facts Panel with cartoon characters (NF + C) (n = 83), considered the control groups, 3) Warning Labels (WL) (n = 109), and 4) Warning Labels with cartoon characters (WL + C) (n = 96). After allocation, children assigned to both WL groups (WL or WL + C), were randomly required to watch two posters simultaneously or a video explaining how to correctly interpret WLs. Logistic regression models adjusted by sex, age and cluster (school) were fitted.ResultsThe percentage of children correctly choosing the healthiest or the unhealthiest option was higher for WL groups (56.8, 95%CI; 40.8–72.8) compared to NF groups (24.3, 95%CI; 20.4–28.3,p < 0.05). The understanding of traditional WL was higher (28.7, 95%CI: 22.8–35.4) than the numeric WL (19, 95%CI: 14.2–25.0,p < 0.05). But, correct answers for identifying healthy and unhealthy products were higher for numeric WL than for NF groups. Cartoon characters reduced the percentage of correct answers for choosing unhealthiest products (WL + C: 48.9, 95%CI: 25.6–72.4 vs WL: 58.7, 95%CI: 36.4–81.1,p < 0.05). The video was 2.23 times more helpful than the posters to the correct interpretation of the WL (p < 0.05).ConclusionsIn scholar Mexican children, traditional and numeric WL were useful to identify healthier and unhealthier packaged products in comparison to NF, suggesting that both WL formats may effectively communicate the excessive content of nutrients of concern among children. Cartoon characters may reduce the objective understanding of the WL, underscoring the need to regulate advertising directed to children along with the implementation of front-of-pack labeling.
A deep image-to-image network organ segmentation algorithm for radiation treatment planning: principles and evaluation
Authors: Marschner Sebastian , Datar Manasi , Gaasch Aurélie , Xu Zhoubing , Grbic Sasa , Chabin Guillaume , Geiger Bernhard , Rosenman Julian , Corradini Stefanie , Niyazi Maximilian , Heimann Tobias , Möhler Christian , Vega Fernando , Belka Claus , Thieke Christian 
Published: July 2022

Abstract
Background
We describe and evaluate a deep network algorithm which automatically contours organs at risk in the thorax and pelvis on computed tomography (CT) images for radiation treatment planning.

Methods
The algorithm identifies the region of interest (ROI) automatically by detecting anatomical landmarks around the specific organs using a deep reinforcement learning technique. The segmentation is restricted to this ROI and performed by a deep image-to-image network (DI2IN) based on a convolutional encoder-decoder architecture combined with multi-level feature concatenation. The algorithm is commercially available in the medical products “syngo.via RT Image Suite VB50” and “AI-Rad Companion Organs RT VA20” (Siemens Healthineers). For evaluation, thoracic CT images of 237 patients and pelvic CT images of 102 patients were manually contoured following the Radiation Therapy Oncology Group (RTOG) guidelines and compared to the DI2IN results using metrics for volume, overlap and distance, e.g., Dice Similarity Coefficient (DSC) and Hausdorff Distance (HD95). The contours were also compared visually slice by slice.

Results
We observed high correlations between automatic and manual contours. The best results were obtained for the lungs (DSC 0.97, HD95 2.7 mm/2.9 mm for left/right lung), followed by heart (DSC 0.92, HD95 4.4 mm), bladder (DSC 0.88, HD95 6.7 mm) and rectum (DSC 0.79, HD95 10.8 mm). Visual inspection showed excellent agreements with some exceptions for heart and rectum.

Conclusions
The DI2IN algorithm automatically generated contours for organs at risk close to those by a human expert, making the contouring step in radiation treatment planning simpler and faster. Few cases still required manual corrections, mainly for heart and rectum.
Efficacy and safety of modified Xiao-Feng Powder in the treatment of chronic urticaria: protocol of a randomized double-blind placebo-controlled study
Authors: Hung Hing Yu , Song Tianhe , Loo Steven King Fan , Chan Kam Leung , Ching Jessica Yuet Ling , Sum Chi Him , Lo Louis Cho Wing , Chia Sarah Chon Pin , Ho Ray Tin Muk , Cheong Pui Kuan , Siu Tony Hon Chung , Leung Ka Chun , Lin Zhi-Xiu 
Published: July 2022

Abstract
Background
Chronic Urticaria (CU), a common skin disorder known as Yin Zhen in Chinese medicine, is characterized by recurrent, pruritic, pink-to-red edematous lesions and wheals on the skin. Xiao-Feng Powder (XFP, meaning Wind-Dispersing Powder), is reported to be one of the most frequently used Chinese herbal formulae for CU. In this study, we aim to investigate the effectiveness and safety of modified Xiao-Feng Powder (mXFP) for the treatment of CU.

Methods
In this randomised double-blind placebo-controlled clinical trial, 58 subjects identified as having mild to severe urticaria (Urticaria activity score greater than 10) will be recruited and randomised into two groups to receive antihistamine Bilastine with either mXFP or placebo for 12 weeks, followed by post treatment visits at week 16. The primary outcome measure is the change of weekly urticaria activity score (UAS7) at week 12. Secondary outcome measures include the Urticaria Control Test (UCT), Visual Analog Scale of Itch Severity (VAS), Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL), Angioedema Activity Score (AAS), immunoglobulin E (IgE) test, gut microbiota test and use of antihistamines during study period. The trial will be conducted at three Chinese medicine clinics in Hong Kong.

Expected outcomes
The results of this study will establish robust clinical evidence about the efficacy and safety of mXFP in the treatment of CU. A specific feature of this trial is that it is a integrative medicine trial with subjects being allowed to take the Western and Chinese medicine together for the treatment.
Trial registration This is registered on ClinicalTrials.gov, ID: NCT04967092. Register date: July 19, 2021. https://clinicaltrials.gov/ct2/show/NCT04967092.
Favipiravir and/or nitazoxanide: a randomized, double-blind, placebo-controlled trial of early therapy in COVID-19 in health workers, their household members, and patients treated at IMSS (FANTAZE)
Authors: Smith Tania , Hoyo-Vadillo Carlos , Adom Akosua Agyeman , Favari-Perozzi Liliana , Gastine Silke , Dehbi Hakim-Moulay , Villegas-Lara Beatriz , Mateos Eduardo , González Yessica Sara Pérez , Navarro-Gualito Maria D. , Cruz-Carbajal Alejandra S. , Cortes-Vazquez Miguel A. , Bekker-Méndez Carolina , Aguirre-Alvarado Charmina , Aguirre-Gil Gisela , Delgado-Pastelin Lucero , Owen Andrew , Lowe David , Standing Joseph , Escobedo Jorge 
Published: July 2022

Abstract
Background
The 2020 pandemic of SARS-CoV-2 causing COVID-19 disease is an unprecedented global emergency. COVID-19 appears to be a disease with an early phase where the virus replicates, coinciding with the first presentation of symptoms, followed by a later ‘inflammatory’ phase which results in severe disease in some individuals. It is known from other rapidly progressive infections such as sepsis and influenza that early treatment with antimicrobials is associated with a better outcome. The hypothesis is that this holds for COVID-19 and that early antiviral treatment may prevent progression to the later phase of the disease.

Methods
Trial design: Phase IIA randomised, double-blind, 2 × 2 design, placebo-controlled, interventional trial.
Randomisation: Participants will be randomised 1:1 by stratification, with the following factors: gender, obesity, symptomatic or asymptomatic, current smoking status presence or absence of comorbidity, and if the participant has or has not been vaccinated. Blinding: Participants and investigators will both be blinded to treatment allocation (double-blind).

Discussion
We propose to conduct a proof-of-principle placebo-controlled clinical trial of favipiravir plus or minus nitazoxanide in health workers, their household members and patients treated at the Mexican Social Security Institute (IMSS) facilities. Participants with or without symptomatic COVID-19 or who tested positive will be assigned to receive favipiravir plus nitazoxanide or favipiravir plus nitazoxanide placebo. The primary outcome will be the difference in the amount of virus (‘viral load’) in the upper respiratory tract after 5 days of therapy. Secondary outcomes will include hospitalization, major morbidity and mortality, pharmacokinetics, and impact of antiviral therapy on viral genetic mutation rate. If favipiravir with nitazoxanide demonstrates important antiviral effects without significant toxicity, there will be a strong case for a larger trial in people at high risk of hospitalization or intensive care admission, for example older patients and/or those with comorbidities and with early disease.

Trial registration
ClinicalTrials.govNCT04918927. Registered on June 9, 2021.
The effects of exercise programs on cognition, activities of daily living, and neuropsychiatric symptoms in community-dwelling people with dementia—a systematic review
Authors: Steichele Kathrin , Keefer Anne , Dietzel Nikolas , Graessel Elmar , Prokosch Hans-Ulrich , Kolominsky-Rabas Peter L. 
Published: July 2022

Abstract
Background
The prevalence of dementia is expected to increase dramatically. Due to a lack of pharmacological treatment options for people with dementia, non-pharmacological treatments such as exercise programs have been recommended to improve cognition, activities of daily living, and neuropsychiatric symptoms. However, inconsistent results have been reported across different trials, mainly because of the high heterogeneity of exercise modalities. Thus, this systematic review aims to answer the questions whether exercise programs improve cognition, activities of daily living as well as neuropsychiatric symptoms in community-dwelling people with dementia.

Methods
Eight databases were searched for articles published between 2016 and 2021 (ALOIS, CENTRAL, CINAHL, Embase, MEDLINE, PsycINFO, PubMed, Web of Science). Randomized controlled trials evaluating the effects of any type of physical activity on cognition, activities of daily living, or neuropsychiatric symptoms in community-dwelling people with a formal diagnosis of dementia were included in this systematic review. Two authors independently assessed eligibility and quality of the studies. The methodology was in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines.

Results
Eight publications covering seven trials were included in this review with the majority investigating either a combination of strength and aerobic exercise or aerobic exercise alone. This review revealed that there is no clear evidence for the beneficial effects of exercise on cognition. None of the included trials found an impact on activities of daily living. Although different randomized controlled trials reported inconsistent results, one trial indicated that especially aerobic exercise may improve neuropsychiatric symptoms.

Conclusion
Our systematic review did not confirm the impact of exercise on cognition and activities of daily living in community-dwelling people with dementia. The results suggested that aerobic exercise might be effective to reduce neuropsychiatric symptoms. Well-designed trials including only community-dwelling people with a formal diagnosis of dementia, large samples, long-term follow-ups, and detailed description of adherence to the intervention are needed to improve the scientific evidence on the best type of exercise modality.

Trial registration
PROSPERO, CRD42021246598.
Minimal surgery for tractional retinal detachment secondary to branch retinal vein occlusion: a case report
Authors: Bilgic Alper , Sudhalkar Aditya 
Published: July 2022

Abstract
Background
Tractional retinal detachment secondary to retinal vein occlusion is a complex entity that can be extremely difficult to manage due to an intricate association of the retinal tissue with the fibrovascular proliferation, making vitreous dissection an extraordinarily difficult procedure. Minimal surgery without endo-tamponade can reduce recovery time and avoid complications of surgery, which in some cases can lead to blindness and even phthisis.

Case presentation
A 64-year-old Indian woman presented with progressive worsening of vision (right eye) due to fovea involving tractional retinal detachment secondary to supero-temporal branch retinal vein occlusion. After anterior, core and peripheral vitrectomy, the epicenter of the fibrous bridge causing foveal split was identified and released. The corrected distance visual acuity improved from 6/60 pre-operatively to 6/12 post-operatively. At the 5-year follow-up, the patient remains stable both anatomically and visually.

Conclusions
This case illustrates how careful identification of the epicenter of traction helps maximize visual gain in patients with minimal risk of iatrogenic retinal tears and eliminates the need for endo-tamponade with either gas or silicone oil. Minimal surgery for tractional detachment provides excellent visual gains with minimal risks in select cases.
A dataset of Neotropical liana research focusing on the strategies of control for forest restoration and management practices
Authors: da Cunha Vargas Betânia , Grombone-Guaratini Maria Tereza , Morellato Leonor Patrícia Cerdeira 
Published: July 2022

Abstract
Key message
Forest fragmentation leads to a micro-environmental condition that favors the proliferation of liana, which infest trees, compete with them, and reduce their performance. To report the state of the art of the main actions to manage this structural component of tropical forests, we surveyed the control strategies in the literature in the last 71 years, highlighting research goals, tree-climber interactions, management, restoration, and conservation.
Dataset access is at https://doi.org/10.5281/zenodo.6678112. Associated metadata are available at
https://metadata-afs.nancy.inra.fr/geonetwork/srv/fre/catalog.search#/metadata/712ff481-dfa2-4ddb-b4fa-fcbd7c517842

Context
Lianas (woody vines) are considered structural parasites of tropical trees because they start their development as terrestrial seedlings but need to reach a tree canopy for higher light availability. The tree-liana coexistence usually can damage tree species, thus removing lianas has been suggested as an alternative to reinforce forest regeneration.

Aims
The dataset compilation begun during the first author doctoral work and a first dataset on neotropical lianas was published (https://doi.org/10.5281/zenodo.4050477) in 2020. The present dataset (https://doi.org/10.5281/zenodo.6678112) presents an update of the 2020 dataset with additional amend (published articles from 2018 to 2021) and enhanced metadata descriptions. Our aim is providing an updated database extracted from scientific literature compiling information related to the effect of lianas on tree and forest structure and diversity, and to contribute to improve decision making on forest restoration and management.

Methods
We made a systematic literature review on lianas in the Neotropical region (native or restored) from 1950 to 2021. First, we selected studies on liana management and described each paper according to the following topics: vegetation status, positive (P), and negative (N) effects of lianas on each species, the species in focus, and the suggested management strategy.

Results
Almost 83% of the studies pointed out tree-climber interactions as negative to trees. Cutting was the management strategy adopted in 92% of the studies. Controlled burning, enrichment, and selective cutting were adopted in only one paper. Rainy and seasonal forests were the vegetation types with more studied sites (20 and 17 respectively). Only one study suggested enhancing forest diversity through direct seeding of lianas. Four studies evaluated the impact of lianas on forest diversity and forest fauna.

Conclusion
The data collected showed the different impacts of liana management on the diversity and structure of tropical forests. It can endorse environmental control and management practices and evaluate the consequences of these techniques in recovering forests or improving timber production.
Modification of ALPPS to avoid ischemia and congestion after stage 1: a case report
Authors: Ishihara Mai , Takahashi Yuki , Matsuo Kenichi , Nakamura Akihiro , Togo Shinji , Tanaka Kuniya 
Published: July 2022

Abstract
Background
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been advocated for treating advanced liver tumors, but the devascularized ischemic area resulting from liver parenchymal division can become a nidus for sepsis. We present a patient who underwent ALPPS modified to avoid ischemia and congestion after liver partitioning during stage 1.

Case presentation
ALPPS was carried out for a patient with multiple bilobar liver metastases from rectosigmoid colon cancer. The 2-stage treatment included 3 partial resections within the left lateral section and parenchymal division at the umbilical fissure with right portal vein ligation as stage 1, followed by right trisectionectomy as stage 2. During parenchymal division at the umbilical fissure, Segment 4 portal pedicles and the middle hepatic vein had to be resected at their roots. To safely accomplish this, combined resection of Segment 4 and the drainage area of the middle hepatic vein was performed after parenchymal partition, aiming to avoid ischemia and congestion within the remnant liver. Successful stage 2 hepatectomy followed later. No ischemia or congestion occurred during stage 1 or 2.

Conclusions
During ALPPS, ischemia and congestion after stage 1 must be avoided to reduce morbidity and mortality. The modification described here should reduce likelihood of severe postoperative complications.