bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID‐19 on emergency patients in the resuscitation room: A cross‐sectional study
Authors: Feng Jihua , Yang Yanli , Zheng Xiaowen , Zhao Chunling , Li Hongyuan , Ji Pan , Yu Qiao , Wei Lile , Qin Han , Pang Jielong , Li Bocheng , Zhang Jianfeng 
Published: January 2022

AbstractObjectiveThe purpose of this study was to evaluate the impact of COVID‐19 outbreaks on emergency patients in a resuscitation room in Nanning, China.MethodsA single‐center cross‐sectional retrospective study was conducted in the emergency department of a tertiary public hospital from January 1, 2019, to December 31, 2020, in Nanning, Guangxi, China. We collected the data of patients in the resuscitation room to investigate the number of patients accessing emergency services during the study period. Data in 2020 were compared to the data during the same period in 2019.ResultsThe number of emergency patients in the resuscitation room during the COVID‐19 pandemic has decreased in intrinsic diseases, extrinsic diseases, and pediatric cases, especially in the early stages of the pandemic. Additionally, the length of stay of emergency patients in the resuscitation room was reduced.ConclusionsThe number of emergency patients in the resuscitation room during the pandemic of COVID‐19 in 2020 was reduced compared to that in the same period in 2019 in Nanning, China. This situation shows a serious social problem, which should arouse the attention of the medical profession and the government.
Advanced diagnostic imaging of sentinel lymph node in early stage breast cancer
Authors: Li Ping , Sun Desheng 
Published: January 2022

AbstractSentinel lymph node biopsy has been regarded as the standard procedure for early staging breast cancer. One of the key steps is to locate the sentinel lymph node (SLN). The recommended method is the joint use of blue dye and radioisotope. However, due to radionuclide radiation and high cost, it is urgent to develop more convenient and sensitive imaging methods to accurately locate SLN. This article discusses the advancement of accurately locating SLN by isotope tracer imaging, magnetic tracer method, computed tomographic lymphography, and trans‐lymphatic contrast‐enhanced ultrasound, as well as proposing new propose for clinical diagnosis.
Comparison of clinical competency self‐assessments among Advanced Education in General Dentistry (AEGD) residents before and during COVID‐19 pandemic
Authors: D'Emilio Anna , Sabounchi Shabnam Seyedzadeh , Wu Yinxiang , Kim Amy , Franck Etienne , Kane Daniel , Lieberman Martin 
Published: January 2022

AbstractPurpose/objectivesSelf‐assessment of clinical competence is an important tool for effective learning and training for some educational programs. The New York University (NYU) Langone Hospital's Advanced Education in General Dentistry (AEGD) Program has had its residents complete self‐assessment of clinical competency evaluations for many years. The evaluation is used to understand the residents’ perception of their own clinical skill upon beginning the program and to determine the necessary resources to provide to the residents for them to meet program standards. The same evaluation is completed by the residents 6 months later to determine if they perceived advancement in their clinical performance while in the program. Dental education, along with other fields of education was disrupted by the coronavirus disease 2019 (COVID‐19) pandemic. The purpose of this study was to examine the impact of COVID‐19 on clinical competency self‐assessments among the NYU Langone AEGD residents before and during the pandemic.MethodsIn this cross‐sectional study, data was collected from two AEGD cohorts representing 2019–2020 and 2020–2021 academic years; from July 2019 (n = 196) to January 2020 (n = 189) and July 2020 (n = 202) to January 2021 (n = 184). The self‐assessment evaluations were administered via an online residency management platform on the first days of July and January of the academic year. The survey consisted of 48 questions on “clinical skills and performance” as established by CODA standards for postdoctoral general dentistry programs.ResultsSurvey response rate was 100% for both cohorts. When comparing results, the findings indicate the COVID‐19 pandemic had interrupted clinical learning during dental school. However, training through the AEGD program led to improvements in perceived clinical competence by the residents in mid‐program evaluation.ConclusionThe self‐assessment evaluation can be used as a tool to enhance training as part of the AEGD program's performance improvement plan.
The efficacy of radical antegrade modular pancreatosplenectomy: A systematic review and meta‐analysis
Authors: Watanabe Jun , Rifu Kazuma , Sasanuma Hideki , Kotani Kazuhiko , Sata Naohiro 
Published: January 2022

AbstractBackground/PurposePrevious systematic reviews have shown that radical antegrade modular pancreatosplenectomy (RAMPS) had favorable outcomes including prognosis. However, recent large studies have shown opposite results, thus necessitating clarification of RAMPS efficacy. We aimed to update existing evidence on the clinical outcomes of RAMPS for left‐sided pancreatic cancer by comparing them to those of the conventional approach.MethodsElectronic databases and registries were searched until August 2021 to perform random‐effect meta‐analysis. Methodological quality was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation approach. The protocol was registered at protocols.io (https://doi.org/10.17504/protocols.io.bxhfpj3n).ResultsThirteen cohort studies (1641 patients) and four ongoing randomized controlled trials (RCTs) were identified. RAMPS increased disease‐free survival (hazard ratio [HR] 0.62, 95% confidence interval [CI] = 0.42‐0.91), but it had little effect on overall survival (HR 0.92, 95% CI = 0.79‐1.09) and recurrence‐free survival (HR 0.72, 95% CI = 0.37‐1.38) with low certainty of evidence.ConclusionThe meta‐analysis of recent studies suggests that RAMPS may have little effect on clinical outcomes. These findings highlight the necessity of further studies, including RCTs to determine the efficacy and subsequent indication of RAMPS in clinical cases.
Ultrastructural changes in mitochondria during oogenesis in two phylogenetically close fish species
Authors: Charitonidou Katerina , Panteris Emmanuel , Ganias Kostas 
Published: January 2022

AbstractThe ultrastructure of oocyte mitochondria and their contribution to the endogenous autosynthesis of the yolk was investigated in two clupeoid species, the Mediterranean sardine, Sardina pilchardus, and the European anchovy, Engraulis encrasicolus. The structure and abundance of mitochondria differ in secondary growth oocytes of the two species, whereas they are similar in chromatin nucleolus and primary growth oocytes. Sardine oocytes show a higher percentage of mitochondria in the cytoplasm as they develop. However, the individual size of each mitochondrion decreases, becoming smaller than those observed in anchovy oocytes. The volume fraction of cristae in mitochondria of sardine oocytes gradually increased throughout the oocyte developmental phases up to the early secondary growth phase and then slightly decreased during the mid‐secondary growth phase. In the cytoplasm of early secondary growth oocytes of anchovy, the percentage of mitochondria is larger than in mid‐secondary growth oocytes. As oocytes develop, the size of mitochondria diminishes as well. In contrast to the volume fraction of cristae in mitochondria of sardine oocytes, the volume fraction of cristae in anchovy was decreased in early secondary growth oocytes and then it was increased during the mid‐secondary growth phase. As a result, based on both cytoplasmic dynamics of each species and mitochondrial alterations, it was assumed that mitochondria in sardine play a role in the formation of yolk granules, whereas mitochondria in anchovy play a role in the lipid synthesis pathway. Both species showed exogenous heterosynthesis of yolk, through the process of pinocytosis in the zona radiata of oocytes.
T2‐Weighted MR Imaging‐Derived Radiomics for Pretreatment Determination of Therapeutic Response to Glucocorticoid in Patients With Thyroid‐Associated Ophthalmopathy: Comparison With Semiquantitative Evaluation
Authors: Hu Hao , Chen Lu , Zhang Jiu‐Lou , Chen Wen , Chen Huan‐Huan , Liu Hu , Shi Hai‐Bin , Wu Fei‐Yun , Xu Xiao‐Quan 
Published: January 2022

BackgroundMR imaging has been applied to determine therapeutic response to glucocorticoid (GC) before treatment in thyroid‐associated ophthalmopathy (TAO), while the performance was still poor.PurposeTo investigate the value of T2‐weighted imaging (T2WI)‐derived radiomics for pretreatment determination of therapeutic response to GC in TAO patients, and compare its diagnostic performance with that of semiquantitative parameters.Study TypeRetrospective.PopulationA total of 110 patients (49 ± 12 years; male/female, n = 48/62; responsive/unresponsive, n = 62/48), divided into training (n = 78) and validation (n = 32) cohorts.Field Strength/Sequence3.0 T, T2‐weighted fast spin echo.AssessmentW.C. and H.H. (6 and 10 years of experience, respectively) performed the measurements. Maximum, mean, and minimum signal intensity ratios (SIRs) of extraocular muscle (EOM) bellies were collected to construct a semiquantitative imaging model. Radiomics features from volumes of interest covering EOM bellies were extracted and three machine learning‐based (logistic regression [LR]; decision tree [DT]; support vector machine [SVM]) models were built.Statistical TestsThe diagnostic performances of models were evaluated using receiver operating characteristic curve analyses, and compared using DeLong test. Two‐sided P < 0.05 was considered statistically significant.ResultsThe responsive group showed higher minimum signal intensity ratio (SIRmin) of EOMs than the unresponsive group (training: 1.46 ± 0.34 vs. 1.18 ± 0.39; validation: 1.44 ± 0.33 vs. 1.19 ± 0.20). In both cohorts, LR‐based radiomics model demonstrated good diagnostic performance (area under the curve [AUC] = 0.968, 0.916), followed by DT‐based (AUC = 0.933, 0.857) and SVM‐based models (AUC = 0.919, 0.855). All three radiomics models outperformed semiquantitative imaging model (SIRmin: AUC = 0.805) in training cohort. In validation cohort, only LR‐based radiomics model outperformed that of SIRmin (AUC = 0.745). The nomogram integrating LR‐based radiomics signature and disease duration further elevated the diagnostic performance in validation cohort (AUC: 0.952 vs. 0.916, P = 0.063).Data ConclusionT2WI‐derived radiomics of EOMs, together with disease duration, provides a promising noninvasive approach for determining therapeutic response before GC administration in TAO patients.Level of Evidence3Technical EfficacyStage 4
Correlation between the elastic modulus of anterior cruciate ligament (ACL) and quantitative ultrashort echo time (UTE) magnetic resonance imaging
Authors: Jerban Saeed , Hananouchi Takehito , Ma Yajun , Namiranian Behnam , Dorthe Erik W. , Wong Jonathan H. , Shojaeiadib Niloofar , Wu Mei , Du Jiang , D'Lima Darryl , Chung Christine B. , Chang Eric Y. 
Published: January 2022

AbstractConventional magnetic resonance imaging (MRI) often acquires no signal in anterior cruciate ligament (ACL) due to the short apparent transverse relaxation time of ACL. Ultrashort echo time (UTE) MRI is capable of imaging ACL with high signal which enables quantitative ACL assessment. This study aimed to investigate the correlations of the mechanical and microstructural properties of human ACL specimens with quantitative three‐dimensional UTE Cones (3D‐UTE‐Cones) MRI measures. ACL specimens were harvested from cadaveric knee joints of 13 (50.9 ± 21.1 years old, 11 males and 2 female) donors. Specimens were scanned using a series of quantitative 3D‐UTE‐Cones T2* (UTE‐T2*), T1 (UTE‐T1), Adiabatic T1ρ (UTE‐Adiab‐T1ρ), and magnetization transfer (UTE‐MT) sequences in a wrist coil on a clinical 3T scanner. ACL elastic modulus was measured using a uniaxial tensile mechanical test. Histomorphometry analysis was performed to measure the average fascicle specific surface, fascicle size, and number of cells per unit area. Spearman's rank correlations of UTE‐MRI biomarkers with mechanical and histomorphometry measures were investigated. The elastic modulus of ACL showed significant moderate correlations with UTE‐Adiab‐T1ρ (R = −0.59, p = 0.01), macromolecular fraction from MT modeling (R = 0.54, p = 0.01), magnetization transfer ratio (R = 0.53, p = 0.01), UTE‐T2* (R = −0.53, p = 0.01), and average fascicle specific surface (R = 0.54, p = 0.01). UTE‐MRI showed nonsignificant correlations with histomorphometry measures. UTE‐MRI biomarkers may be useful noninvasive tools for the ACL mechanical assessment.
Male gender is associated with informal caregiver burden in patients with chronic intestinal failure treated with home parenteral nutrition
Authors: Castinel Jean , Pellet Gauthier , Laharie David , Zerbib Frank , Silvain Christine , Wilsius Eva , Kerlogot Laurianne , Rivière Pauline , Poullenot Florian 
Published: January 2022

AbstractBackgroundHome parenteral nutrition (HPN) is the recommended treatment in patients with chronic intestinal failure (CIF). HPN is associated with a worsening of patients' quality of life and has a dramatic impact on personal and familial daily life. Little is known about the informal caregiver burden of patients receiving HPN.AimTo assess informal caregiver burden and the factors associated with moderate‐to‐severe caregiver burden in patients treated with HPN.MethodsInformal caregivers of consecutive patients treated with HPN in a French nutrition referral center were invited to participate in a survey between January 2021 and June 2021. They had to fill out an anonymous standardized self‐questionnaire evaluating burden by the Zarit Burden Interview (ZBI) and depression and anxiety symptoms by the Hospital Anxiety and Depression Scale (HADS) score since HPN introduction.ResultsAmong the 87 HPN patients having informal caregivers, 53 (61%) completed the questionnaire. Thirty (57%) informal caregivers were women. The caregiver's median age was 62 years (IQR, 21.0). Twelve (22%) expressed moderate to severe burden (ZBI score, 41–88). In a multivariate analysis, the caregiver's male gender (odds ratio [OR], 16.45; 95% CI, 2.30–238.75; P = 0.014) and the number of simultaneous infusions per day >1 (OR, 9.92; 95% CI, 1.35–121.60; P = 0.0038) were associated with a moderate to severe burden. Twenty caregivers reported anxious and depressive symptoms with an elevated HADS score.ConclusionIn this prospective survey, a minority of informal caregivers of patients with CIF being treated with HPN expressed moderate to severe burden. The caregiver's male gender was associated with a higher burden in patients with CIF.
Accelerated alveolar bone loss in a mouse model of inflammatory bowel disease and its relationship with intestinal inflammation
Authors: Qiao Dan , Chen Rixin , Li Lingjun , Zhu Feng , Zhang Yangheng , Yan Fuhua 
Published: January 2022

AbstractBackgroundBone loss is a common complication of inflammatory bowel disease (IBD); however, few studies have focused on alveolar bone loss (ABL) in IBD. Herein, we systematically observed ABL in an interleukin (IL)‐10 knockout (IL‐10–/–) mouse model of IBD and explored the possible mechanisms.MethodsIL‐10–/– and age‐matched wild‐type (WT) male mice were sacrificed every 2 weeks from 12 to 24 weeks of age. ABL was determined by microcomputed tomography. Periodontal and intestinal inflammation were evaluated using histological grading and inflammatory factor expression levels. Intestinal barrier integrity and cytokine levels in serum were examined by immunofluorescence and enzyme‐linked immunosorbent assays, respectively. The expression of macrophage phenotype markers, including inducible nitric oxide synthase (iNOS), arginase‐1 (Arg‐1), and bone metabolic markers, including osteoprotegerin, receptor activator of nuclear factor‐κB ligand (RANKL), were measured by immunohistochemistry. The macrophage phenotype in the periodontium was also examined by real‐time quantitative polymerase chain reaction.ResultsCompared with WT mice, IL‐10–/– mice exhibited significant ABL from 18 weeks of age. However, no significant differences were observed in the periodontium between the two groups in either histopathological scores or inflammatory factor levels. In the colon and ileum, these measurements significantly increased in IL‐10–/– mice from 12 and 14 weeks, respectively. Correlation analysis also revealed that ABL in IL‐10–/– mice was positively correlated with intestinal inflammation. Furthermore, IL‐10–/– mice showed a destroyed intestinal barrier and higher serum levels of inflammatory factors. In both the intestine and periodontium, higher iNOS and lower Arg‐1 levels, along with an increase in RANKL expression in the periodontium, were examined in IL‐10–/– mice.ConclusionsAn accelerated ABL spontaneously occurred in IL‐10–/– mice and was correlated more with inflammation of the intestine than periodontium. Immunopathological changes may be the potential cause of abnormal alveolar bone metabolism.
Acibenzolar‐S‐methyl activates mitogen‐activated protein kinase cascade to mediate chlorophyll and carotenoid metabolisms in the exocarp of Docteur Jules Guyot pears
Authors: Li Canying , Zhu Jie , Cheng Yuan , Hou Jiabao , Sun Lei , Ge Yonghong 
Published: January 2022

AbstractBACKGROUNDAcibenzolar‐S‐methyl (ASM), a well‐known plant activator, has been used to protect fruit and vegetable from fungal invasion and maintain quality. However, little is known about the molecular mechanism of ASM in regulating chlorophyll and carotenoid metabolisms. Therefore, Docteur Jules Guyot pears were used as the materials to study the changes of hydrogen peroxide (H2O2) production, mitogen‐activated protein kinase (MAPK) cascade, transcription factors, chlorophyll, and carotenoid metabolisms after ASM and PD98059 (a MAPK cascade blocker) treatments.RESULTSASM increased NADPH oxidase (NOX) and superoxide dismutase (SOD) activities, and H2O2 content, promoted PcMAPKKK1, PcMAPKK3, and PcMAPK6 expressions, and down‐regulated PcMYC2, PcPIF1, PcPIF3, and PcPIF4 expressions in exocarp of pears. ASM also delayed the decrease of chlorophyll a and b contents, and inhibited the accumulation of β‐carotene, lycopene and lutein, PcNYC1, PcHCAR, PcPPH, PcSGR1/2, PcPAO, PcPSY, PcLCYB, PcCRTZ2, PcCCS1 expressions, and promoted PcLCYE expression. PD98059 + ASM treatments depressed SOD and NOX activities and H2O2 content, inhibited PcMAPKKK1, PcMAPKK3, PcMAPK6, PcPIF1, and PcPIF3 expressions, and promoted PcMYC2 and PcPIF4 expressions in exocarp of pears. Additionally, PD98059 + ASM accelerated PcNYC1, PcHCAR, PcPPH, PcSGR1/2, PcPAO, PcPSY, PcCYB, PcCRTZ2, and PcCCS1 expressions, thereby reducing chlorophyll a and b contents, and promoting β‐carotene, lycopene and lutein contents.CONCLUSIONSPostharvest ASM treatment promoted the production of H2O2 to activate the MAPK cascade, then phosphorylated/dephosphorylated transcription factors expression, and delayed chlorophyll decomposition and carotenoid synthesis in pears. © 2022 Society of Chemical Industry.
Durable, Lightweight, Washable and Comfortable Cooling Textiles from Nanodiamond/Polydopamine/Wool Nanocomposites
Authors: Rehman Aisha , Houshyar Shadi , Mirabedini Azadeh , Cheng Deshan , Cai Guangming , Padhye Rajiv , Wang Xin 
Published: January 2022

AbstractThe development of cooling textiles has a significant impact on energy saving and cost‐effectiveness in the context of global warming. Engineering textiles with cooling performance while maintaining their intrinsic traits, for example, lightweight, washable, comfort, and durability, is a great challenge in developing personal cooling garments. Here, the synthesis of nanodiamond/polydopamine/wool (ND‐PDA‐wool) nanocomposites through a facile dip‐coating approach is demonstrated. Different types of ND including detonation ND (DND), carboxylated ND (ND‐COOH) and hydroxylated ND (ND‐OH), are used, and dopamine templating is applied to achieve strong adhesion and bonding between fiber and ND. The morphology, structure, and properties of the as‐coated fabrics are characterized, and the cooling performance together with comfort are measured. Due to the excellent thermal conductivity of ND, the temperature difference between the coated fabrics and uncoated ones is around 2.4–3.9 °C within a short time span of 30 min. The coated ND‐PDA‐Wool fabrics demonstrated enhanced thermal stability and improved mechanical properties with excellent durability, and the water absorbency is greatly enhanced with well‐maintained air permeability. ND‐PDA‐wool composite fabrics offer a strategy to develop durable, lightweight, washable, and comfortable cooling textiles with immense potential in energy saving and reducing space cooling costs.
Monitoring DNA Hybridization with Organic Electrochemical Transistors Functionalized with Polydopamine
Authors: Sensi Matteo , Migatti Giulio , Beni Valerio , D'Alvise Tommaso Marchesi , Weil Tanja , Berto Marcello , Greco Pierpaolo , Imbriano Carol , Biscarini Fabio , Bortolotti Carlo Augusto 
Published: January 2022

AbstractOrganic electrochemical transistors (OECTs) are finding widespread application in biosensing, thanks to their high sensitivity, broad dynamic range, and low limit of detection. An OECT biosensor requires the immobilization of a biorecognition probe on the gate, or else on the channel, through several, often lengthy, chemical steps. In this work, a fast and straightforward way to functionalize the carbon gate of a fully screen‐printed OECT by means of a polydopamine (PDA) film is presented. By chemical immobilization of an amine‐terminated single‐stranded oligonucleotide, containing the HSP70 promoter CCAAT sequence, on the PDA film, the detection of the complementary DNA strand is demonstrated. Furthermore, the specificity of the developed genosensor is assessed by comparing its response to the fully complementary strand with the one to partially complementary and noncomplementary oligonucleotides. The developed sensor shows a theoretical limit of detection (LOD) of 100 × 10−15 m and a dynamic range over four orders of magnitude.
Unprecedented Dual Role of Polyaniline for Enhanced Pseudocapacitance of Cobalt–Iron Layered Double Hydroxide
Authors: Mahmood Azhar , Zhao Bolin , Javed Muhammad Sufyan , He Dequan , Cheong Weng‐Chon , Han Dongxue , Niu Li 
Published: January 2022

AbstractCreating nanosized pores in layered materials can increase the abundant active surface area and boost potential applications of energy storage devices. Herein, a unique synthetic strategy based on polyaniline (PANI) doped 2D cobalt–iron layered double hydroxide (CoFe‐LDH/P) nanomaterials are designed, and the formation of pores at low temperature (80 °C) is developed. It is found that the optimized concentration of PANI creates the nanopores on the CoFe‐LDH nanosheets among all other polymers. The well‐ordered pores of CoFe‐LDH/P allow the high accessibility of the redox‐active sites and promote effective ion diffusion. The optimized CoFe‐LDH/P2 cathode reveals a specific capacitance 1686 (1096 Cg−1) and 1200 Fg−1 (720 Cg−1) at 1 and 30 Ag−1 respectively, a high rate capability (71.2%), and a long cycle life (98% over 10 000 cycles) for supercapacitor applications. Charge storage analysis suggests that the CoFe‐LDH/P2 electrode displays a capacitive‐type storage mechanism (69% capacitive at 1 mV s−1). Moreover, an asymmetric aqueous supercapacitor (CoFe‐LDH/P2//AC) is fabricated, delivering excellent energy density (75.9 Wh kg−1 at 1124 W kg−1) with outstanding stability (97.5%) over 10 000 cycles. This work opens a new avenue for designing porous 2D materials at low temperature for aqueous energy storage devices.