bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acupuncture therapies for postherpetic neuralgia: a protocol for a systematic review and Bayesian network meta-analysis
Authors: Bian Zhiyuan , Yu Jie , Tu Mingqi , Liao Binjun , Huang Jingmei , Izumoji Genki , Sun Ruohan , Xu Yunyun , Jiang Yongliang , He Xiaofen , Fang Jianqiao 
Published: March 2022

IntroductionPostherpetic neuralgia (PHN) is the most common sequela of herpes zoster, and it is often refractory to guideline-recommended treatments. Acupuncture therapy, a wildly applied complementary-alternative treatment, may help in the management of PHN. Diverse types of acupuncture therapy for PHN have been proposed, however, their comparative efficacies remain unclear. This study protocol plans to compare the efficacy and safety of different acupuncture therapies for PHN.Methods and analysisDatabases including MEDLINE, Embase, Cochrane Library, Web of Science, Chinese Biomedical Database, China National Knowledge Infrastructure, VIP Database, Wanfang Database, WHO International Clinical Trials Registry Platform, ClinicalTrials.gov, Chinese Clinical Trial Register and OpenGrey will be searched from their inception to January 2022. Randomised controlled trials (RCTs) assessing the effectiveness of acupuncture therapy on the management of PHN will be selected. The primary outcome is pain intensity. Secondary outcomes include negative emotions, sleep condition, quality of life and adverse events. Reviewers will conduct study selection, data extraction and risk of bias assessment procedures. Then, standard pair-wised meta-analysis and Bayesian network meta-analysis will be performed (if applicable). The Confidence in Network Meta-Analysis application will be used to assess the confidence in the evidence for the primary outcome.Ethics and disseminationAll data used for this study will be extracted from published RCTs, thus, no ethical approval will be required. The results of this systematic review will be disseminated through peer-reviewed journal and conference presentation.PROSPERO registration numberCRD42020219576.
Impact of disease activity outcome measures reporting in the medical records of patients with axial spondyloarthritis on the retention rates of biological treatment: the example of secukinumab use in daily practice in France
Authors: Dougados Maxime , Lucas Julien , Desfleurs Emilie , Lukas Cédric , Saraux Alain , Tournadre Anne , Ruyssen-Witrand Adeline , Wendling Daniel , Goupille Philippe , Claudepierre Pascal 
Published: March 2022

ObjectivesTo estimate the frequency of reporting composite indices evaluating axial spondyloarthritis (axSpA) disease activity in daily practice and to assess its impact on the secukinumab (SEC) retention rate.MethodsStudy design: Retrospective, multicentre. Data collected: (1) Recommended composite indices: Bath Ankylosing Spondyltitis Disease Activity Index (BASDAI) +C reactive protein or Ankylosing Spondylitis Disease Activity Score (ASDAS) at the time of initiation of SEC and at least once during the first year of follow-up; (2) Drug retention rate: percentage of patients still on SEC over time according to whether at least one recommended composite index had been optimally reported.ResultsA recommended composite index has been collected in 22% of the 906 enrolled axSpA patients. The percentage of patients still on treatment after 1, 2 and 3 years of follow-up was greater in those for whom at least one composite index had been optimally reported (respectively, 64% (57–71) vs 57% (54–61), 55% (48–62) vs 41% (38–45) and 52% (44–59) vs 38% (34–42), log rank test, p=0.016) with a lower risk of SEC discontinuation for these patients (HR: 0.70 (95% CI 0.5 to 0.88), Cox model, p=0.003).ConclusionThis study suggests that reporting of recommended composites indices for monitoring axSpA might be associated with higher retention rates of biological therapies.
Geographical prevalence of family history in patients with axial spondyloarthritis and its association with HLA-B27 in the ASAS-PerSpA study
Authors: Boel Anne , van Lunteren Miranda , López-Medina Clementina , Sieper Joachim , van der Heijde Desirée , van Gaalen Floris A 
Published: March 2022

BackgroundA positive family history (PFH) of spondyloarthritis (SpA) consists of five SpA-related entities, of which a PFH of axial spondyloarthritis (axSpA) is most common in European patients with axSpA. Moreover, a PFH of axSpA is associated with human leucocyte antigen B27 (HLA-B27) positivity in these patients. It is unknown if this holds true in patients with axSpA in other parts of the world.ObjectiveTo investigate the geographical prevalence of a PFH of SpA and its association with HLA-B27 positivity in patients with axSpA worldwide.MethodsCross-sectional analyses included patients from the ASAS peripheral involvement in Spondyloarthritis (PerSpA) study from 24 countries worldwide with an axSpA diagnosis, known HLA-B27 status and family history. Logistic regression models were built to assess the effect of HLA-B27 status on the occurrence of PFH. This was repeated for each of the five SpA entities in a PFH.ResultsAmong 2048 patients, axSpA was the most common SpA entity in a PFH in all geographical regions (Asia 28%, Europe and North America 27%, Latin America 20%, Middle East and North Africa 41%). A PFH of axSpA was associated with HLA-B27 positivity in Asia (OR 4.19), Europe and North America (OR 2.09) and Latin America (OR 3.95), but not in the Middle East and North Africa (OR 0.98), which has a lower prevalence of HLA-B27 positivity. A PFH of other SpA entities was less prevalent and not consistently associated with HLA-B27 positivity.ConclusionIn patients with axSpA worldwide, axSpA was consistently the most common SpA entity in a family history and was associated with HLA-B27 positivity in all geographical regions but one.
Chair's letter
Authors: Carterette Ben 
Published: March 2022

Dear IR community,
It is happening again. Conferences that were planning to host in-person events in the first half of 2022 are switching to fully virtual events. WSDM 2022 is the latest to do so, following CHIIR 2022 which made the switch in December. While this is disappointing for all of us that were hoping to travel again, and especially heartbreaking for the conference organizers, it is clearly the right thing to do given lockdowns and travel restrictions being reinstated in countries around the world. We continue to plan for a hybrid SIGIR 2022 with an in-person event in Madrid, taking into account the possibility of COVID-related restrictions that may reduce its size---or force us to cancel altogether.
Supporting search engines with knowledge and context
Authors: Voskarides Nikos 
Published: March 2022

Search engines leverage knowledge to improve information access. Such knowledge comes in different forms: unstructured knowledge (e.g., textual documents) and structured knowledge (e.g., relationships between real-world objects and topics). In order to effectively leverage knowledge, search engines should account for context, i.e., information about the user and query. In this thesis, we aim to support search engines in leveraging knowledge while accounting for context.
In the first part of this thesis, we study how to make structured knowledge more accessible to the user when the search engine proactively provides such knowledge as context to enrich search results. As a first task, we study how to retrieve descriptions of knowledge facts from a text corpus. Next, we study how to automatically generate knowledge fact descriptions. And finally, we study how to contextualize knowledge facts, that is, to automatically find facts related to a query fact.
In the second part of this thesis, we study how to improve interactive knowledge gathering. We focus on conversational search, where the user interacts with the search engine to gather knowledge over large unstructured knowledge repositories. We study multi-turn passage retrieval as an instance of conversational search and focus on query resolution, that is, add missing context from the conversation history to the current turn. We model query resolution as a term classification task and propose a method to address it.
In the final part of this thesis, we focus on search engine support for professional writers in the news domain. We study how to support such writers create event-narratives by exploring knowledge from a corpus of news articles. We propose a dataset construction procedure for this task that relies on existing news articles to simulate incomplete narratives and relevant articles. We study the performance of multiple rankers, lexical and semantic, and provide insights into the characteristics of this task.

Awarded by
: University of Amsterdam, Amsterdam, The Netherlands on 5 February 2021.

Supervised by
: Maarten de Rijke.

Available at
: https://hdl.handle.net/11245.1/78187b29-2403-4711-800a-0f92fcb9b15c.
N6-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) as a Novel Mediator of Statin Effects in Human Endothelial Cells
Authors: Mo Wentao , Chen Ziqi , Zhang Xiaozhe , Dai Gang , Ma Dongwei , Pan Jiajie , Zhang Xinxia , Wu Guifu , Fan Wendong 
Published: March 2022

Background:
N6-methyladenosine (m6A) plays a critical role in various biological processes. However, no study has addressed the role of m6A modification in the statin-induced protection of endothelial cells (ECs).

Methods:
Quantitative real-time polymerase chain reaction and Western blotting analyses were used to study the expression of m6A regulatory genes in atorvastatin-treated ECs. Gain- and loss-of-function assays, methylated RNA immunoprecipitation analysis, and dual-luciferase reporter assays were performed to clarify the function of FTO (fat mass and obesity-associated protein) in ECs.

Results:
Atorvastatin decreased FTO protein expression in ECs. The knockdown of FTO enhanced the mRNA and protein expression of KLF2 (Kruppel-like factor 2) and eNOS (endothelial NO synthase) but attenuated TNFα (tumor necrosis factor alpha)-induced VCAM-1 (vascular cell adhesion molecule 1) and ICAM-1 (intercellular adhesion molecule 1) expression, as well as the adhesion of monocytes to ECs. Conversely, FTO overexpression significantly upregulated the mRNA and protein levels of VCAM-1 and ICAM-1, downregulated those of KLF2 and eNOS, and strongly attenuated the atorvastatin-mediated induction of KLF2 and eNOS expression. Subsequent investigations demonstrated that KLF2 and eNOS are functionally critical targets of FTO. Mechanistically, FTO interacted with KLF2 and eNOS transcripts and regulated their expression in an m6A-dependent manner. After FTO silencing, KLF2 and eNOS transcripts with higher levels of m6A modification in their 3′ untranslated regions were captured by YTHDF3 (YT521-B homology m6A RNA-binding protein 3), resulting in mRNA stabilization and the induction of KLF2 and eNOS protein expression.

Conclusions:
FTO might serve as a novel molecular target to modulate endothelial function in vascular diseases.
“Our πολίτευμα Belongs in Heaven” (Phil 3:20)
Authors: Muir Alex W. 
Published: March 2022

Abstract
This article argues that Paul’s narrative about collective πολίτευμα in heaven (Phil 3:20) constitutes a moment of climactic consolation in the letter to the Philippians. This position is reached through an extended comparison with Seneca’s On Consolation to Mother Helvia (Ad Helviam). It emerges that similar narratives of consolation are constructed in the Ad Helviam and Phil 3:15–21. In both texts, adversity is recognised and rationalised, before it is defied then transcended through rhetorical and cosmological arguments. There are, however, also differences owing to Paul’s and Seneca’s different contexts: in particular, the threat of certain Judaizing opponents to Paul’s gospel in Philippi.
Name Theology in John 1:14
Authors: Oh DongWoo 
Published: March 2022

Abstract
In his recent studies, Jörg Frey has proposed that the biblical tradition of Shekhina can be discerned in the expression of the Logos’s dwelling among the believers in John 1:14. Interacting with Frey, this study proposes that Name theology, which account for the temple’s connection with the name of the Lord in the Old Testament, is utilized in John 1:14. The name of the Lord in connection with the temple can be a useful resource to explain the paradoxical identity of the Logos as well as the usage of the glory in the verse. Furthermore, this Name theology can coexist with the biblical tradition of Shekhina in John 1:14.
Constitutional Changes in Populist Times
Authors: Szente Zoltán 
Published: March 2022

Abstract
The article examines the impacts of populist government in Hungary on constitutional law since 2010. The criterion of the analysis is whether the comprehensive and radical changes that took place during this time have been characterized by the distinctive traits, ambitions and values that the scholarship attributes to populism and ‘populist constitutionalism’, above all anti-elitism, anti-institutionalism, anti-pluralism, the emphasis on popular sovereignty and direct democracy, and an instrumental conception of law. For this purpose, it examines the major changes in the constitutional rules and practice of sovereignty issues, the system of separation of powers, and fundamental rights. The article consists of four parts. In the first chapter, sovereignty issues are discussed including the changing approach of constituent power, constitutional identity, and the interpretation of sovereignty through an analysis of the 2011 Fundamental Law and its eight amendments. The study then reviews the changes in the system of separation of powers, that is, the transformation of the legal status and operational practices of the most important public law institutions. The next chapter provides a qualitative analysis of the situation of fundamental rights, in particular the trends in the renewed regulation of constitutional liberties and political freedoms. In addition, this part gives an assessment of the current state of institutional protection of constitutional rights. Finally, the last chapter seeks to answer the question of how the cumulative effects of these changes can be assessed; whether Hungary follows a new, specific path of constitutional development, or the constitutional changes can be interpreted within the framework of the constitutional democracy formed after the 1989/90 regime change.
Illegal Legality and the Façade of Good Faith – Migration and Law in Populist Hungary
Authors: Hoffmann Tamás 
Published: March 2022

Abstract
Hungarian migration regulation has undergone a radical transformation since 2015, resulting in a system that essentially deprives asylum seekers of any international protection. This was a strategic move by the government to portray itself as the defender of Hungary and even Europe of the menace of uncontrolled migration. This article critically analyzes this transformation by first giving a comprehensive account of the major legislative changes and showing how they were framed to boost the populist political propaganda of the government. Then it argues that even though such populist legalism is in clear contravention of Hungary’s international legal obligations and thus constitute bad faith action, the European Union is still powerless to effectively oppose these measures since its own asylum policies are aimed at maintaining “Fortress Europe”, i.e. restricting irregular migration as much as possible through legal and informal measures. In conclusion, the only real antidote to populist legalism would be acting in good faith.
Sectoral Special Taxes in Hungary as Instruments of a Populist Fiscal Policy: A Legal Analysis
Authors: Varju Marton , Papp Mónika 
Published: March 2022

Abstract
In order to meet a variety of locally relevant socio-economic expectations and needs, Hungarian tax policy in the last decade has applied a number of unconventional instruments. The government favored in particular the imposition of additional taxes on corporate taxpayers in specific sectors of the national economy. The taxation of turnover in addition to corporate profits has proved to be a particularly attractive idea. These measures pursue declared objectives which any national government that is faithful to its political mandate could endorse as its own. However, the design of these taxes and their related regulatory hiatuses, which have been subject to extensive scrutiny before the courts of the European Union, raise the possibility of their abusive and discriminatory use to the disadvantage of select individuals, in particular non-national corporate taxpayers. This element of contemporary Hungarian tax policy may well be considered as forming part of the government’s populist policy agenda.
A Short History of Transport in Japan from Ancient Times to the Present
Authors: Black John Andrew 
Published: March 2022

A Short History of Transport in Japan from Ancient Times to the Present is a unique study: the first by a Western scholar to place the long-term development of Japanese infrastructure alongside an analysis of its evolving political economy. Drawing from New Institutional Economics, Black offers an historically informed critique of contemporary planning using the example of Japan’s historical institutions, their particular biases, and the power they have exerted over national and local transport, to identify how reformed institutional arrangements might develop more sustainable and equitable transport services.
With chapters addressing each major form of transport, Black examines the predominant role of institutions and individuals – from seventeenth-century shoguns to post-war planners – in transforming Japan’s maritime infrastructure, its roads and waterways, and its adoption of rail and air transport. Using a multidisciplinary, comparative, and chronological approach, the book consults a range of technical, cultural, and political sources to tease out these interactions between society and technology.
This spirited new contribution to transport studies will attract readers interested in institutional power, the history of transport, and the development of future infrastructure, as well as those with a general interest in Japan.
Rethinking Warning Compliance and Complacency by Examining How People Manage Risk and Vulnerability during Real-World Tornado Threats
Authors: Demuth Julie L. , Vickery Jamie , Lazrus Heather , Henderson Jen , Morss Rebecca E. , Ash Kevin D. 
Published: March 2022

Abstract
The weather community has a keen interest in whether or not people comply with tornado warnings by taking shelter when a tornado threatens. When people do not seek shelter, a commonly attributed reason is that they are complacent due to overwarning, false alarms, routine exposure and experience with tornadoes and warnings, or time between damaging events. Yet, there is a lack of research that focuses on whether people are actually complacent, i.e., whether they ignore or are unwilling to prepare for the threat. We explore whether people exhibit these indicators of complacency by examining how people assessed their risk and responded during real-world tornado threats and how vulnerability influenced these processes. Our analysis is based on in-person interviews with 23 survivors of two deadly EF3 tornadoes that occurred approximately 50 miles apart and within 12 h of each other. Contrary to a threat-disbelieving, threat-ignoring, nonpreparing, and thus complacent public, we instead found that people actively managed their risk from the tornadoes, meaning they actively attended to, evaluated, and responded to the tornado risk as it evolved in space and time. We further found, however, that many people felt limited or lack of efficacy to respond due to static and situational factors that resulted in them having no safe place to seek protection from the threat. Based on this rich, nuanced analysis, we provide recommendations about important ways that the weather community and its partners can mitigate the risks people face from tornadoes, now and in the long term.
Putting the Significance of Spectral Peaks on the Level: Implications for the 1470-Yr Peak in Greenland δ18O
Authors: Huybers Peter 
Published: March 2022

Abstract
Spectral analysis of the Greenland Ice Sheet Project 2 (GISP2) δ18O record has been interpreted to show a 1/(1470 yr) spectral peak that is highly statistically significant (p < 0.01). The presence of such a peak, if accurate, provides an important clue about the mechanisms controlling glacial climate. As is standard, however, statistical significance was judged relative to a null model, H0, consisting of an autoregressive order one process, AR(1). In this study, H0 is generalized using an autoregressive moving-average process, ARMA(p, q). A rule of thumb is proposed for evaluating the adequacy of H0 involving comparing the expected and observed variances of the logarithm of a spectral estimate, which are generally consistent insomuch as removal of the ARMA structure from a time series results in an approximately level spectral estimate. An AR(1), or ARMA(1, 0), process is shown to be an inadequate representation of the GISP2 δ18O structure, whereas higher-order ARMA processes result in approximately level spectral estimates. After suitably leveling GISP2 δ18O and accounting for multiple hypothesis testing, multitaper spectral estimation indicates that the 1/(1470 yr) peak is insignificant. The seeming prominence of the 1/(1470 yr) peak is explained as the result of evaluating a spectrum involving higher-order ARMA structure and the peak having been selected on the basis of its seeming anomalous. The proposed technique for evaluating the significance of spectral peaks is also applicable to other geophysical records.

Significance Statement
A suitable null hypothesis is necessary for obtaining accurate test results, but a means for evaluating the adequacy of a null hypothesis for a spectral peak has been lacking. A generalized null model is presented in the form of an autoregressive, moving-average process whose adequacy can be gauged by comparing the observed and expected variance of log spectral density. Application of the method to the GISP2 δ18O record indicates that spectral structure found at 1/(1470 yr) is statistically insignificant.
Pattern of sudden cardiac deaths
Authors: Sharma Gaurav , Hugar Basappa S , Praveen S , P Yajaman Girish Chandra , Kanchan Tanuj 
Published: March 2022

Background and objective Sudden cardiac death can be defined as a sudden, unexpected death caused by loss of heart function. Notwithstanding major developments in the diagnosis and treatment of heart disease, it remains the major contributing factor for deaths. This considers the pattern of sudden cardiac deaths. Methodology: This prospective study was conducted on all cases subjected to medico-legal autopsy in the forensic medicine department at a tertiary care hospital for a period of 18 months. All sudden cardiac deaths satisfying the WHO criteria were included. Unknown cases and bodies in advanced stage of decomposition were excluded. Results Sudden cardiac deaths accounted for 55% (82 cases) of 149 cases of sudden natural deaths and 6.5% of total autopsies conducted. The age group most commonly affected by sudden cardiac death ranged from 31 to 50 years. The majority of the cadavers had 90–95% degree of stenosis of left anterior descending artery, 70–80% of right coronary artery and 60–70% left circumflex artery. Coronary insufficiency was the major cause for sudden cardiac deaths with a total of 53 (64.63%) cases. Conclusion Sudden cardiac deaths accounted for 6.5% of all the autopsies conducted and males outnumbered females with M:F ratio of 10.7:1, with mean age of 44.5 ± 12.63 years. The largest number – 60.97% – were aged between 31 and 50 years. Coronary insufficiency accounted for 64.63% of sudden cardiac deaths.