bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intimate partner violence against Peruvian women and adequate regulation of emotions and behaviors of their children between 24 and 59 months of age: A cross-sectional study at the national level
Authors: Pickling-Barrionuevo Rosela , Hernández-Vásquez Akram , Torres-Guillén Ana Lucía , Mendoza-Correa Isabel , Bendezu-Quispe Guido 
Published: July 2022

Objective: Determine the association between intimate partner violence against Peruvian women and adequate regulation of the emotions and behaviors of children between 24 and 59 months old. Methods: This cross-sectional study analyzed secondary data obtained from the ENDES-2019. The dependent variable was the regulation of emotions and behaviors in 24 to 59-month-old children. The independent variable was partner violence (physical, sexual, verbal or psychological) against mothers at some point in their life. Prevalence ratios (PR) were calculated and adjusted with their 95% confidence interval (CI) to evaluate the association between intimate partner violence and adequate regulation of emotions and behaviors. Results: Data from 8,473, 15 to 49-year-old mothers and their children aged 24 to 59 months were analyzed. Intimate partner violence was reported by 57.1% of the women, and 31.6% of the children showed adequate regulation of emotions and behaviors. The probability of children of mothers who were victims of intimate partner violence adequately regulating their emotions and behaviors was low (aPR = 0.81, 95% CI: 0.75–0.88), with an aPR = 0.82 (95% CI: 0.76–0.89) and an aPR = 0.84 (95% CI: 0.76–0.93) for those with mothers suffering psychological or physical violence, respectively, with no differences in children of mothers suffering sexual violence by their partner. Conclusions: Six out of 10 Peruvian women have suffered partner violence at some point in their life, and only three out of 10 children between 24 and 59 months old adequately regulate their emotions and behaviors. Children of mothers suffering physical and verbal or psychological violence by their partners were less likely to regulate their emotions and behaviors adequately.
Efficacy and Safety of Multiple Whole-Body Cleansing With Aqueous 0.5% Chlorhexidine in Stable NICU Preterm Infants—Randomized Controlled Trial
Authors: Anitha Murugesan , Sundaram Mangala Bharathi , Kumutha Jayaraman 
Published: July 2022

Background: Single application of chlorhexidine soon after birth reduces skin colonization. The benefit is not sustained after 72 h and multiple repeated cleansing is suggested. Such interventions especially in preterm infants need evaluation. Objective: To evaluate efficacy and safety of multiple whole-body cleansing with aqueous 0.5% chlorhexidine during first week in preterm infants. Study Design: Randomized controlled trial with superiority design and triple blinding. Setting: Level-III neonatal intensive care unit of teaching hospital in India. Participants: A total of 120 hemodynamically stable preterm (28-34 weeks) infants without encephalopathy weighing ≥ 1,000 g admitted within 6 h of life. Intervention: Following stratified randomization (28-31 weeks n = 31; 32-34 weeks n = 89), 59 and 61 infants were cleansed with identically looking aqueous 0.5% chlorhexidine wipes and placebo (sterile-water wipes) respectively at 0, 48, and 96 h after recruitment and followed up until neonatal period. Outcomes: Primary outcome was skin colonization rate on day 7. Secondary outcomes include neonatal mortality, incidence of sepsis, adverse skin reactions, and hypothermic episodes and colony counts during first week. Results: We used intention to treat analysis. After multiple cleansings, skin colonization on day 7 with chlorhexidine was 50.9% (28/55) and sterile water was 92.8% (52/56). Risk reduction with chlorhexidine cleansing was 45% compared with sterile water (relative risk = 0.55; 95% confidence interval [CI]: 0.42,0.72). Absolute risk reduction = 41.95% (95% CI: 27.1, 56.78) and number needed to treat = 2.4 persons (95% CI: 1.8, 3.7). Neonatal mortality (10.1% vs 16.3%, P = .539), sepsis (10.1% vs 19.6%, P = .229) was not significant. None had adverse skin reactions. Temperature loss after wet cleansing was not different between chlorhexidine and water. Conclusion: Multiple whole-body cleansing with aqueous 0.5% chlorhexidine at 48 h interval during first week of life reduces skin colonization in preterm infants.
Intellectual Functioning of Children With Isolated PRS, PRS-Plus, and Syndromic PRS
Authors: Malarbi Stephanie , Chisholm Anita K. , Gunn-Charlton Julia K. , Burnett Alice C. , Tan Tiong Yang , Cheng Shirley S. W. , Pellicano Anastasia , Shand Jocelyn , Heggie Andrew , Hunt Rod W. 
Published: July 2022

Objective Describe the intelligence quotient (IQ) of children with Pierre Robin sequence (PRS). Design Prospective cohort study. Setting Neurodevelopmental follow-up clinic within a hospital. Patients Children with PRS (n = 45) who had been in the Neonatal Intensive Care Unit (NICU) were classified by a geneticist into 3 subgroups of isolated PRS (n = 20), PRS-plus additional medical features (n = 8), and syndromic PRS (n = 17) based on medical record review and genetic testing. Main Outcome Measure Children with PRS completed IQ testing at 5 or 8 years of age with the Wechsler Preschool and Primary Scale of Intelligence, Third Edition (WPPSI-III) or Fourth Edition (WPPSI-IV) or the Wechsler Intelligence Scale for Children, Fourth Edition (WISC-IV) or Fifth Edition (WISC-V). Results IQ scores were more than 1 to 2 standard deviations below the mean for 36% of the overall sample, which was significantly greater compared to test norms (binomial test P = .001). There was a significant association between PRS subtype and IQ (Fisher’s exact P = .026). While only 20% of children with isolated PRS were within 1 standard deviation below average and 35% of children with syndromic PRS were below 1 to 2 standard deviations, 75% of PRS-plus children scored lower than 1 to 2 standard deviations below the mean. Conclusion PRS subgroups can help identify children at risk for cognitive delay. The majority of children with PRS-plus had low intellectual functioning, in contrast to the third of children with syndromic PRS who had low IQ and the majority of children with isolated PRS who had average or higher IQ.
Cost-Effective Modeling of Thromboembolic Chemoprophylaxis for Total Ankle Arthroplasty
Authors: Martinazzi Brandon J. , Kirchner Gregory J. , Stauch Christopher M. , Lorenz F. Jeffrey , Manto Kristen M. , Bonaddio Vincenzo , Koroneos Zachary , Aynardi Michael C. 
Published: July 2022

Background: Symptomatic venous thromboembolism (VTE) following total ankle arthroplasty (TAA) can cause substantial morbidity and mortality. To prevent this complication, surgeons often prescribe postoperative chemoprophylaxis. However, much controversy exists regarding the efficacy of chemoprophylaxis because of the limited studies exploring its use. Furthermore, even less is known about its cost-effectiveness. Therefore, this study sought to determine the cost-effectiveness of commonly prescribed chemoprophylactic agents using a break-even analysis economic model. Methods: The literature was searched, and an online database was used to identify patients who developed a symptomatic VTE after undergoing TAA. Our institutional records were used to estimate the cost of treating a symptomatic VTE, and an online drug database was used to obtain the cost of commonly prescribed chemoprophylactic agents. A break-even analysis was then performed to determine the final break-even rate necessary to make a drug cost-effective. Results: The low and high rates of symptomatic VTE were determined to be 0.46% and 9.8%. From 2011 to 2021, a total of 3455 patients underwent total ankle arthroplasty. Of these patients, 16 developed a postoperative symptomatic VTE (1.01%). Aspirin 81 mg was cost-effective if the initial symptomatic VTE rates decreased by an absolute risk reduction (ARR) of 0.0003% (NNT = 31 357). Aspirin 325 mg was also cost-effective if the initial rates decreased by an ARR 0.02% (NNT = 5807). Likewise, warfarin (5 mg) was cost-effective at all initial rates with an ARR of 0.02% (NNT = 4480). In contrast, enoxaparin (40 mg) and rivaroxaban (20 mg) were only cost-effective at higher initial symptomatic VTE rates with ARRs of 1.48% (NNT = 68) and 5.36% (NNT = 19). Additional analyses demonstrated that enoxaparin (40 mg) and rivaroxaban (20 mg) become cost-effective when costs of treating a symptomatic VTE are higher than our estimates. Conclusion: Chemoprophylaxis following TAA can be cost-effective. A tailored approach to VTE prophylaxis with cost-effectiveness in mind may be beneficial to the patient and health system.
Revision total hip arthroplasty for aseptic loosening compared with primary total hip arthroplasty for osteoarthritis: long-term clinical, functional and quality of life outcome data
Authors: Koutalos Antonios A , Varitimidis Sokratis , Malizos Konstantinos N , Karachalios Theofilos 
Published: July 2022

Purpose: The aim of this study was the comparative assessment of long-term clinical (subjective and objective), functional and quality of life outcome data between primary and revision THA. Methods: 122 patients (130 hips) who underwent cementless revision THA of both components (TMT cup, Wagner SL stem, Zimmer Biomet) for aseptic loosening only (Group A) were compared to a matched group of 100 patients (100 hips) who underwent cementless primary THA for osteoarthritis (Synergy stem, R3 cup, Smith & Nephew) (Group B). Outcomes were evaluated with survival analysis curves, Harris Hip Score (HHS), WOMAC, Oxford Hip Score (OHS), Short-Form Health Survey (SF-12) and EQ-5D-5L scales. Mobility was assessed with walking speed, Timed Up And Go Test (TUG), Parker Mobility Score, Lower Extremity Functional Scale (LEFS) and UCLA scores. Results: At a mean follow-up of 11.1 (8–17) years a cumulative success rate of 96% (95% CI, 96–99%) in Group A and 98% (95% CI, 97–99%) in Group B with operation for any reason as an endpoint was recorded. Statistically significant differences between groups were developed for WOMAC (Mann-Whitney U-test, p = 0.014), OHS (Mann-Whitney U-test, p = 0.020) and physical component of SF-12 scores (Mann-Whitney U-test, p = 0.029) only. Group A had less improvement in function as compared with group B. In Group A, in multiple regression analysis, patients’ cognition ( p = 0.001), BMI ( p = 0.007) and pain ( p = 0.022) were found to be independent factors influencing functional recovery (WOMAC). Similarly, pain ( p = 0.03) was found to influence quality of life (EQ-5D-5). Conclusions: In the long term, revision THA shows satisfactory but inferior clinical, functional, and quality of life outcomes when compared to primary THA. Residual pain, BMI and cognitive impairment independently affect functional outcomes.
Management of periprosthetic joint infection of shoulder arthroplasty: Single-stage versus two-stage protocols. A systematic review and meta-analysis of the literature
Authors: Fiore Michele , Ferra Lorenzo , Giannini Claudio , Sambri Andrea , Filippini Matteo , Tedeschi Sara , Zamparini Eleonora , Viale Pierluigi , De Paolis Massimiliano , Guerra Enrico 
Published: July 2022

Background The treatment of shoulder prosthetic joint infections (PJIs) requiring removal of the prosthesis is not well defined. This article aims to systematically review and compare the results of the literature in single-stage and two-stage protocols in the treatment of shoulder PJI. Methods An in-depth search on PubMed/Scopus/Web of Science databases and cross-referencing search was carried out concerning the articles reporting detailed data on the topic. Results A total of 486 shoulder PJIs were included: 137 treated with single-stage and 349 with two-stage procedure. A similar distribution between early and not-early infections (19.1% vs 80.9%) was found between the two groups. The overall rate of success in terms of PJI eradication was significantly higher in the single-stage group (95.6% vs 85.7%, p < 0.001). The non-infection-related complications rate was 13.8% in the single-stage group and 37.6% in the two-stage group ( p < 0.001), the non-infection-related revision rate was 8% and 18.9%, respectively ( p = 0.005). Discussion The single-phase protocol showed a higher success rate in eradicating the infection and a lower complication rate. However, the low number of patients included, the low quality of the articles, the lack of data on clinical severity and bacteriological virulence suggest caution in conclusions.
Paper 06: The Natural History of Nonoperative Treatment of Posterior Instability in a High Demand Population
Authors: Bedrin Micheal , Yow Bobby , Nelson Sarah , LeClere Lance , Dickens Jonathan , Mescher Patrick 
Published: July 2022

Objectives: Nonoperative management of posterior shoulder instability is common, however there is limited data available to assess the pathomorphology of nonoperative management. The purpose of this study is to evaluate glenohumeral pathomorphology in shoulders with posterior glenohumeral instability treated nonoperatively. Methods: We conducted a retrospective review of a consecutive series of patient with isolated posterior shoulder instability defined as an isolated posterior labral tear with a corresponding positive Jerk or Kim test. Patients were excluded if they had prior shoulder surgery or absence of a Jerk or Kim test. Non-operative management was defined as a trial of formal physical therapy pursuit of nonsurgical modalities for a minimum 6 months. Patients who underwent non-operative management and subsequently had a repeat MRI of the initially injured shoulder were identified, and the two studies were compared to evaluate for changes in glenoid bone loss, glenoid morphology, cartilage injuries, and the presence of concurrent pathology. Our primary outcome was glenoid changes associated with failure of non-operative management, which was defined as reoperation and/or medical separation from the military due to the injured shoulder. Secondary outcomes included evaluation of potential risk factors for failure of non-operative management including glenoid bone loss, glenoid version, and posterior humeral head subluxation. Continuous variables were compared with student’s t-test or Fisher exact test when appropriate. Categorical variables were analyzed using Chi-squared. Multivariable regression analysis was used to evaluate risk factors for failure. Results: 42/90 (46.7%) patients failed a 6-month trial of nonoperative management after being diagnosed with posterior glenohumeral instability and went onto receive an arthroscopic stabilization procedure. The failure group demonstrated a significantly greater humeral head subluxation ratio than the cohort of patients who survived nonoperative management (0.65 ± 0.2 vs 0.62 ± 0.2; p = 0.0375). Of those who failed nonoperative management only 17 had repeat MRI’s for comparison with initial MRI’s, which revealed a significantly greater increase in glenoid bone loss (6.54 ± 1.59 vs 2.68 ±1.71; p = 0.00274). The mean time from index MRI and repeat MRI was 488 days (95% CI 317 to 658). Conclusions: In patients that underwent 6-months of nonoperative management for isolated posterior glenohumeral instability, failure occurred approximately 47% of the time and was associated with a greater posterior humeral head subluxation ratio on index MRI than those who did not fail. Additionally, those who had repeat MRI on average 1.3 years later demonstrated greater glenoid bone loss when compared to the index MRI.
Paper 15: Micro-Fragmented Adipose Tissue versus Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: A Prospective Randomized Controlled Trial at 2-year follow-up
Authors: Di Martino Alessandro , Andriolo Luca , Boffa Angelo , Poggi Alberto , Kon Elizaveta , Filardo Giuseppe , Zaffagnini Stefano 
Published: July 2022

Objectives: Pre-clinical and clinical studies supported the use of intra-articular micro-fragmented adipose tissue (MF-AT) injections to address knee osteoarthritis (OA), suggesting their safety and clinical benefits. Nevertheless, no high-level studies investigated the potential of MF-AT over other biological products like platelet-rich plasma (PRP). The aim of this randomized controlled trial (RCT) was to compare a single injection of MF-AT to PRP in terms of clinical outcome and disease-modifying properties in patients with symptomatic knee OA. Methods: A total of 118 patients with symptomatic knee OA were randomly assigned to: single intra-articular MF-AT vs single intra-articular PRP injection. All patients were evaluated before the injection and at 1, 3, 6, 12, and 24 months with the International Knee Documentation Committee (IKDC) subjective score, the Knee injury and Osteoarthritis Outcome Score (KOOS) pain subscales, the EuroQol-Visual Analogue Scale (EQ-VAS) and EuroQol-5D (EQ-5D), and the Visual Analogue Scale (VAS). The treated knees were evaluated at baseline and at 6, 12, and 24 months of follow-up with radiographs and high-resolution (1.5 T) magnetic resonance imaging (MRI) with the Whole-Organ Magnetic Resonance Imaging Score (WORMS). Results: Both MF-AT and PRP provided a statistically and clinically significant improvement up to the last follow-up of 24 months. No differences were found between MF-AT and PRP groups in terms of adverse events (18.9% vs 10.9%), failures (15.1% vs 25.5%), and all clinical outcomes at all follow-ups. Radiographs and MRI findings did not show significant changes after the injection, neither as improvement, nor as disease progression, with no intergroup difference. Patients with moderate/severe OA treated with MF-AT showed a significantly higher IKDC improvement at 6 months compared to PRP (15.7±19.0 vs 8.6±14.2, p=0.041). Similarly, more patients with moderate/severe OA treated with MF-AT reached the minimal clinically important difference (MCID) for the IKDC subjective score at 6 months compared to the PRP group (75.0% vs 34.6%, p=0.005). Conclusions: A single intra-articular injection of both MF-AT and PRP provided a significant clinical improvement up to 24 months in patients with symptomatic knee OA. Both treatments showed a comparable low number of failures and adverse events, without signs of disease progression. Overall, no differences could be documented in both clinical and imaging results between the two biological approaches. Compared with PRP, MF-AT provided a higher clinical improvement at 6 months in moderate-severe OA.
Paper 32: All-inside meniscus repair leads to higher rate of failure compared to inside-out meniscus repair in elite athletes
Authors: Webster Emily , Jones Mary , Williams Andy , Borque Kyle 
Published: July 2022

Objectives: The popularization of ‘all-inside’ meniscal repair devices has led to a paradigm shift away from the historical gold standard of ‘inside-out’ meniscus repair but without comparative studies to support the change. The purpose of this study was to compare the failure rate of ‘all-inside’ and ‘inside-out’ meniscus repair performed in elite athletes. Methods: A retrospective review was performed of all professional or national/international level amateur athletes who underwent meniscal repair between January 1, 2013 and December 31, 2018, with a minimum of two year follow-up. Repairs were classified as ‘all-inside’ or ‘inside-out’ depending on the type of repair performed. Failure was defined as undergoing a subsequent surgery to address a persistent meniscal tear following repair. Results: 158 (106 lateral and 52 medial) meniscal repairs were performed on elite athletes during this time period. Overall, 38 out of 158 (24.1%) underwent subsequent meniscectomy or revision meniscal repair. 27 of 88 (30.7%) of ‘all-inside’ meniscal repairs failed versus 11 of 70 (15.7%) of ‘inside-out’ meniscal repairs (p=0.029). For medial meniscus repairs, ‘all-inside’ failed at a higher rate than ‘inside-out’ medial meniscus repairs (58.6% vs 26.1%. p=0.019) but no statistical difference was found in lateral meniscus repairs (16.9% vs 10.6%, p=0.354). Overall 23 out of 52 (44.2%) of medial meniscus repairs failed compared to 15 of 106 (14.2%) of lateral meniscus repairs (p=0.00003) Cruciate ligament reconstruction was performed at the same time with 27 of 29 ‘all-inside’ medial meniscus repairs, 21 of 23 ‘inside-out’ medial meniscus repairs, 45 of 59 ‘all-inside’ lateral meniscus repairs but only 18 of 47 ‘inside-out’ lateral meniscal repairs. Conclusions: ‘All-inside’ meniscal repair led to a higher rate of failure compared to ‘inside-out’ meniscus repair in elite athletes. Medial meniscus repairs failed at a high rate than lateral meniscal repairs. This difference is even more noteworthy considering that only a minority of inside out lateral meniscal repairs were done in conjunction with a cruciate ligament reconstruction versus the majority of the other three groups studied. Due to the increased knee loading in elite sports, clinically relevant differences between the medial and lateral meniscus as well as repair strategies were elucidated that may not be in the general population. UPLOAD- https://planion-client-files.s3.amazonaws.com/AOSSM/blobs/fb465a3d-3b0f-451f-8fad-0d1332b8b428/1/Meniscal_repair_chart.docx None None None
Paper 33: Serum and Urine Biomarkers for Treatment Monitoring after Meniscal Allograft Transplantation in a Preclinical Canine Model
Authors: Stoker Aaron , Leary Emily , Bozynski Chantelle , Stannard James , Cook James , Ewing Michael 
Published: July 2022

Objectives: To analyze serum and urine biomarker concentrations for their capabilities in delineating differences in assessments of pain and functional outcomes after meniscus allograft transplantation (MAT) in a preclinical canine model. The study was designed to test the hypothesis that serum and urine biomarkers could be used for prognostic (1- and 3-month post-surgical time points) and diagnostic (6-month time point) assessments, based on strong associations with clinically relevant pain and function outcomes after MAT. Methods: Twelve adult, purpose-bred research hounds were included and underwent medial meniscal release (MR) to induce medial compartment gonarthrosis. Three months following MR, medial MAT was performed using: fresh-frozen meniscus (n=4), fresh meniscus (n=4), or fresh menisco-tibial OCA (n=4). Serum and urine from all dogs were collected preoperatively and at 1, 3, and 6 months following MAT. Validated outcome measures for pain, function, effusion, knee range of motion, and gait kinetics were collected at these same timepoints. To develop a prognostic panel of biomarkers, biomarker data from the 1-month and 3-month post-MAT surgery timepoints were used to model 6-month outcomes. A diagnostic panel of biomarkers was developed using biomarker data from the 6-month post-MAT surgery to model 6-month outcomes. Results: Across prognostic biomarker panels, serum biomarkers were mainly represented. A panel including serum IL-6, IL-8, IL-10, and IL-18 had strong model fit for prognostication of the gait kinetics outcome, operated limb %Total Pressure Index (%TPI) (R2=.45). Whereas, a biomarker panel including serum CTX-II and OPG had strong model fit for prognostication of the primary pain-related outcome, VAS pain (R2=.52). Across diagnostic biomarker panels, a panel including serum MMP-1 and MMP-3 and urine PINP and TIMP-1 had strong model fit as diagnostic biomarkers for %TPI (R2=.86). Whereas, a panel including urine CTX-I, CTX-II, IL-8, MMP-2, and TIMP-1 had strong model fit as diagnostic biomarkers for VAS pain (R2=.44). Conclusions: Biomarker panels of selected serum and/or urine proteins highly correlate with clinically-relevant metrics for pain and function outcomes in a preclinical model of meniscus allograft transplantation.