bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rethinking nonprofit service disintermediation through service communication interactions
Authors: Mitchell Sarah-Louise , Clark Moira K. 
Published: April 2022

PurposeA significant management issue for nonprofit organisations (NPOs) is the disconnect between services beneficiaries and the funders of those services. Individual donors and fundraisers provide the resources to enable other people (or animals) to be supported. The purpose of this paper is to address this service management challenge through new types of customer service interactions that bring together service donors and service recipients through innovative digital communication.Design/methodology/approachBased on a review, and illustrated by recent examples of innovative best practice, the authors develop a new conceptual framework for understanding the relationship between customer participation and service brand communication.FindingsThe paper starts by identifying the problem of “nonprofit service disintermediation”. The paper also outlines the inadequacies of popular frameworks of communication, widely taught in business schools, to understand the new reality of customer-service organisation engagement in the digital age. Through adopting a customer engagement lens, the paper develops a new conceptual framework for understanding the relationship between customer participation and service brand communication.Research limitations/implicationsGiven the authors’ focus on the intersection between new communication opportunities and customer service interactions, this paper adds novel insight to theory and raises important implications for management.Originality/valueThe paper explores how, through these new communication interactions, engagement with, and loyalty to, the brand is built over time in a fluid and dynamic way. It identifies a disintermediated relationship, distinct to other service contexts, but significant in terms of value and social impact.
Do Americans seek pleasure while Chinese care about others’ approval? Examining stereotypical utilities positioning in brand choice contexts
Authors: Friedmann Enav , Weiss-Sidi Merav , Vescovi Tiziano 
Published: April 2022

Purpose
Past marketing research has found that hedonic utility is more important for Western cultures, whereas social utility is more important for Eastern cultures, suggesting differential positioning in each culture. However, the research has so far focused on a single choice context of one brand. This paper aims to examine cultural differences in utility importance using two brand choice contexts: single choice and brand selection.

Design/methodology/approach
Four studies (n = 1268) were conducted. Study 1 focused on a single choice context by asking directly about utility importance when choosing a cellphone. Study 2 focused on a brand selection context using conjoint analysis for the same cellphone category used in Study 1. To validate the results of Studies 1 and 2 with the categories of perfume, sports shoes and computers, Study 3 analyzed single and selection contexts using latent regression methods. Finally, Study 4 explored the role of cognitive load in explaining the differences between the two choice contexts using the laptop category.

Findings
The analyses of the brand selection context, which simulates real-life choice, revealed that the importance ascribed to utilities was not idiosyncratic for each culture. In contrast, single-choice contexts demonstrated stereotypical cultural differences.

Originality/value
Positioning a specific utility message to fit the culture stereotype might not be necessary, as it does not always affect brand choice in a competitive environment.
The triple helix and the quality of the startup ecosystem: a global view
Authors: Flechas Ximena Alejandra , Kazunari Takahashi Carlos , Bastos de Figueiredo Júlio César 
Published: April 2022

PurposeThe ongoing business dynamics show two aspects for generating innovation: first, high-impact innovations are developed jointly by several actors, such as universities, enterprises, and governments. Second, startups are better suited to develop innovation during crises or periods of low growth as experienced at the moment. Based on these aspects and drawing on the constructs of the triple helix, this study analyzes the influence between the characteristics of the actors on the quality of the startup ecosystem from a global view.Design/methodology/approachThe study examines the cross-section data of 35 countries between 2017 and 2018 and applies the partial least squares structural equation modeling (PLS-SEM) for assessing the relationships between the triple helix on the quality of the startup ecosystem on a country-level.FindingsThe findings suggest that each actor of the triple helix individually does not positively affect the quality of the startup ecosystem. Yet, when analyzing the actors jointly by creating a second-order latent variable (i.e. triple helix), the study found out that in this way, the triple helix construct has a positive effect on the quality of the startup ecosystem.Originality/valueAlthough a large body of prior literature indicates the importance of generating interrelationships among the different entities involved in ecosystems, few studies provide empirical evidence from a global perspective of the need for these entities to act in an overlapping manner. The present study supports previous research and reinforces the importance of the triple helix for a more innovative environment.
Collective foraging: Experimentally increased competition decreases group performance exploiting a permanent resource
Authors: Beltrão Patrícia , Gomes Ana Cristina R. , Cardoso Gonçalo C. 
Published: April 2022

Abstract

Foraging collectively offers advantages, such as access to social information on food locations, but it may also intensify competition for local resources. Social information may be most advantageous during ecologically challenging conditions, when food sources are scarce or unpredictable, which predicts more collective foraging during such conditions. Alternatively, higher within‐group competition when resources are scarce might destabilize social groups and reduce collective foraging.

To evaluate these effects, we experimentally decreased the number and predictability of food sources (feeders with ad libitum seeds) available to wild‐caught common waxbills Estrilda astrild living in a large open‐air mesocosm.

Compared to control periods, in the treatment with few food sources competitive aggressiveness at feeders increased, the social network became more fragmented, with on average weaker associations between individuals, and foraging groups became smaller. Foraging groups also spent less time per visit to the feeding area, individuals spent less time at the feeders per group visit and had to make more visits to the feeding area per day, all of which indicate less efficient exploitation of the food sources. These effects were also observed when the number of feeders changed unpredictably across days.

Even though the collective behaviour of waxbills appeared to exacerbate, rather than mitigate, the ecological challenges of reduced or unpredictable food sources, we suggest that, in nature, this increased aggressiveness and fragmentation of the social network may function adaptively as an early trigger to explore alternative foraging locations before local food sources are severely depleted.

Read the free Plain Language Summary for this article on the Journal blog.
Fluorodeoxyglucose positron emission tomography scans in patients with alcohol use disorder
Authors: Bralet Marie‐Cécile , Mitelman Serge A. , Goodman Chelain R. , Lincoln Samantha , Hazlett Erin A. , Buchsbaum Monte S. 
Published: April 2022

AbstractBackgroundDiminished uptake of fluorodeoxyglucose (FDG) has been observed in patients with alcohol use disorder (AUD) but little statistical contrast of the regional brain deficits has been undertaken. This study examined prefrontal cortex inter‐regional Brodmann area differences to delineate patterns associated with behavioral, neurotransmitter, and general toxicity hypotheses of cerebral involvement in AUD.MethodsWe obtained data from FDG positron emission tomography (PET) and anatomical magnetic resonance imaging (MRI) for 87 patients with AUD and 41 age‐ and sex‐matched healthy volunteers. Patients were alcohol dependent and had negative breathalyzer tests at the time of imaging. They were assessed with the Beck Depression Inventory, Alcohol Urge Questionnaire, Obsessive Compulsive Drinking Scale, Spielberger State/Trait Anxiety Scale, Buss–Durkee Hostility Inventory, and the Drinker Inventory of Consequences (DrInC). PET images were co‐registered to MRI and both voxel × voxel statistical mapping and stereotaxic regions of interest were obtained.ResultsCompared with healthy volunteers, patients with AUD had lower relative metabolic rates in the frontal, temporal, and parietal lobes, localizable most prominently to the dorsolateral and nearly all orbital prefrontal cortex, superior temporal gyrus, and inferior parietal lobule. In contrast, metabolic rates in the medial orbitofrontal and anterior cingulate cortex, and the subcortical structures (thalamus, cerebellum, ventral striatum, and the dorsal raphe nucleus) in patients were significantly greater. The severity of alcohol‐related consequences as assessed by the DrInC scale was most highly associated with lower metabolism in the caudate, dorsolateral prefrontal, frontopolar, and anteroposterior cingulate cortex.ConclusionsDespite widespread metabolic abnormalities, decreases in AUD were most marked in frontal executive areas, consistent with diminished impulse control, and increases were most prominent in the striatum and cingulate areas, consistent with a suppressed reward system.
Peritoneal natural killer cell chemotaxis is decreased in women with pelvic endometriosis
Authors: Ushiwaka Takashi , Yamamoto Shinpei , Yoshii Chika , Hashimoto Shoko , Tsuzuki Tamami , Taniguchi Kayo , Izumiya Chiaki , Kobayashi Hiroaki , Maeda Nagamasa 
Published: April 2022

AbstractProblemNK cell and macrophage function are decreased in endometriosis, and the disease may involve reduced immune surveillance in the peritoneal cavity. NK cell cytotoxicity and migration ability (chemotaxis) are considered important; the former has been investigated, but the latter has not.Method of studyWe compared chemotaxis of immunocompetent cells (NK cells, macrophages, T cells) in peritoneal fluid obtained during laparoscopy in 27 women with and 13 without endometriosis. Peripheral blood NK cells were also obtained by the peripheral blood antibody beads method. Micro‐cultured cells were examined by time‐lapse photography, and the mean migration speed per cell was calculated as the chemotaxis. We investigated the relationship between chemotaxis and endometriosis.ResultsNK cell chemotaxis was significantly lower in the endometriosis group. Macrophages and lymphocytes were not significantly different between the groups. During menstruation, NK cell chemotaxis decreased in both groups. Postmenstrual chemotaxis was increased significantly in women without endometriosis but remained low in women with endometriosis. The Revised‐American Society for Reproductive Medicine score was not correlated with chemotaxis; in women with endometriosis, chemotaxis was decreased even at early stages. Peripheral blood NK cells showed no significant differences.ConclusionsIn women with endometriosis, not only cytotoxicity but also chemotaxis by NK cells in peritoneal cavity is significantly decreased, and particularly chemotaxis is decreased throughout the menstrual cycle. Therefore, antigens in retrograde menstrual blood that enters the peritoneal cavity might be left unprocessed. Repetition of this immune process in the peritoneal cavity may lead to the onset and subsequent progression of endometriosis.
Power and responsibility: How different sources of CEO power affect firms' corporate social responsibility practices
Authors: Jia Xingping , Liao Shudi , Van der Heijden Beatrice , Li Wenqian 
Published: April 2022

AbstractDoes greater CEO power come with more responsibility? Previous scholarly work in this field entails divergent results on this question. Based on the upper echelons theory and CEO power literature, this study aimed to explore the mechanisms underlying how different sources of CEO power, including structural, ownership, expert, and prestige power, affect firms’ corporate social responsibility (CSR) practices and whether such relationships are moderated by firm visibility. Using a panel dataset comprising 6604 yearly observations of Chinese publicly traded firms from 2009 to 2019, we found that structural power is negatively related to CSR practices and that expert power is positively related to CSR practices, whereas ownership power and prestige power have no direct relationship with CSR practices. Our results show that firm visibility weakens the negative relationship between structural power and CSR practices and strengthens the relationship between expert power and CSR practices, respectively. Overall, this study reconciles the mixed results of previous studies on the impact of CEO power on CSR and integrates the effect of firm visibility as a contextual factor. This article concludes with practical recommendations on how to manage CSR engagement.
Autonomy concerns with using contracts to enhance patient adherence
Authors: Strassle Camila Losada , Schwan Ben , Berkman Benjamin E. 
Published: April 2022

AbstractThe failure of many patients with chronic conditions to correctly follow medical advice that they hope or intend to follow is a major concern, especially as effective long‐term therapies for chronic conditions materialize. Some US healthcare providers have responded with strategies that involve implementing contracts with their patients, including provisions that may deny future treatments after continued nonadherence. This is among the first articles to explicitly discuss the ethics of patient contracts.
‘Now that I am connected this isn't social isolation, this is engaging with people’: Staying connected during the COVID‐19 pandemic
Authors: Spassiani Natasha A. , Becaj Mojca , Miller Clare , Hiddleston Andrew , Hume Aaron , Tait Stephan 
Published: April 2022

AbstractBackgroundThe COVID‐19 global pandemic has put adults with intellectual/developmental disabilities at greater risk of being socially excluded due to physical distancing. Technology has been looked at as a tool for adults with intellectual/developmental disabilities to stay connected, however, little is known about this topic. The purpose of this study was to explore how a grassroots disability organisation used technology to help adults with intellectual/developmental disabilities feel socially connected during the pandemic.MethodsData were collected through questionnaires, attendance records, and field notes; and analysed through trend and thematic analysis.FindingsFour main themes emerged from the data: active leadership, mental wellbeing, technology/digital inclusion, and safety.ConclusionThese findings suggest that when participants overcome technological barriers they found it easy to socially connect online during lockdown.
A framework to integrate innovations in invasion science for proactive management
Authors: van Rees Charles B. , Hand Brian K. , Carter Sean C. , Bargeron Chuck , Cline Timothy J. , Daniel Wesley , Ferrante Jason A. , Gaddis Keith , Hunter Margaret E. , Jarnevich Catherine S. , McGeoch Melodie A. , Morisette Jeffrey T. , Neilson Matthew E. , Roy Helen E. , Rozance Mary Ann , Sepulveda Adam , Wallace Rebekah D. , Whited Diane , Wilcox Taylor , Kimball John S. , Luikart Gordon 
Published: April 2022

ABSTRACTInvasive alien species (IAS) are a rising threat to biodiversity, national security, and regional economies, with impacts in the hundreds of billions of U.S. dollars annually. Proactive or predictive approaches guided by scientific knowledge are essential to keeping pace with growing impacts of invasions under climate change. Although the rapid development of diverse technologies and approaches has produced tools with the potential to greatly accelerate invasion research and management, innovation has far outpaced implementation and coordination. Technological and methodological syntheses are urgently needed to close the growing implementation gap and facilitate interdisciplinary collaboration and synergy among evolving disciplines. A broad review is necessary to demonstrate the utility and relevance of work in diverse fields to generate actionable science for the ongoing invasion crisis. Here, we review such advances in relevant fields including remote sensing, epidemiology, big data analytics, environmental DNA (eDNA) sampling, genomics, and others, and present a generalized framework for distilling existing and emerging data into products for proactive IAS research and management. This integrated workflow provides a pathway for scientists and practitioners in diverse disciplines to contribute to applied invasion biology in a coordinated, synergistic, and scalable manner.
‘This battle, between your gut feeling and your mind. Try to find the right balance’: Parental experiences of children with spinal muscular atrophy during COVID‐19 pandemic
Authors: Oude Lansink Irene L. B. , van Stam P. C. Carolien , Schafrat Eline C. W. M. , Mocking Manouk , Prins S. Dido , Beelen Anita , Cuppen Inge , van der Pol W. Ludo , Gorter Jan Willem , Ketelaar Marjolijn 
Published: April 2022

AbstractAimsParents of children with spinal muscular atrophy (SMA) often struggle with the all‐consuming nature of the demands of caring for a child with substantial physical needs. Our aim was to explore experiences, challenges and needs of parents of a child with SMA in a COVID‐19 pandemic situation.MethodNineteen parents of 21 children (15 months to 13 years of age) with SMA types 1–3 participated in semi‐structured interviews in June to July 2020. The interviews were analysed using inductive thematic analysis.ResultsParents mentioned the protection of the health and well‐being of the child as the central perspective and driving force during the COVID‐19 pandemic. Three subthemes were identified: (1) responsibility, (2) balancing vulnerability and resilience and (3) (in)security.Some parents focused on the positive aspects during the lockdown, such as continuation of nusinersen treatment and family life. Some parents described helpful and positive cognitions to cope with the situation. In general, parents described a need for information with regard to COVID‐19 and their child with SMA and a need for discussing their dilemmas and insecurities with a healthcare professional.InterpretationParents put the health and well‐being of their children first during the pandemic. From this study, we learned that parents of children with SMA need information and value direct contact with a healthcare professional to share their dilemmas and insecurities. The dialogue can help to empower parents in the conflicts and decisions they have to make during a pandemic.
Immune cell subsets in interface cutaneous immune‐related adverse events associated with anti‐PD‐1 therapy resemble acute graft versus host disease more than lichen planus
Authors: Almodovar Cruz Guillermo E. , Kaunitz Genevieve , Stein Julie E. , Sander Inbal , Hollmann Travis , Cottrell Tricia R. , Taube Janis M. , Sunshine Joel C. 
Published: April 2022

AbstractBackgroundCheckpoint immunotherapy is frequently associated with cutaneous immune‐related adverse events (cirAEs), and among those, the most common subtype shows interface reaction patterns that have been likened to lichen planus (LP); however, cutaneous acute graft versus host disease (aGVHD) may be a closer histopathologic comparator. We used quantitative pathology to compare the immunologic composition of anti‐PD‐1‐associated interface reactions to LP and aGVHD to assess for similarities and differences between these cutaneous eruptions.MethodsImmunohistochemistry for CD4, CD8, CD68, PD‐1, and PD‐L1 was performed on formalin‐fixed paraffin‐embedded tissue from patients with anti‐PD‐1 interface cirAEs (n = 4), LP (n = 9), or aGVHD (n = 5). Densities of immune cell subsets expressing each marker were quantified using the HALO image analysis immune cell module. Plasma cell and eosinophil density were quantified on routine H&E slides.ResultsSpecimens from patients with anti‐PD‐1 interface cirAEs showed equivalent total cell densities and immune cell composition to those with aGVHD. Patients with LP showed higher total immune cell infiltration, higher absolute T‐cell densities, increased CD8 proportion, and reduced histiocytic component. The cases with the highest plasma cell counts were all anti‐PD‐1 interface cirAEs and aGVHD.ConclusionThe composition of immune cell subsets in anti‐PD‐1 interface cirAEs more closely resembles the immune response seen in aGVHD than LP within our cohort. This warrants a closer look via advanced analytics and may have implications for shared pathogenesis and potential treatment options.
Erenumab in chronic migraine: Experience from a UK tertiary centre and comparison with other real‐world evidence
Authors: Khalil Modar , Moreno‐Ajona David , Villar‐Martínez María Dolores , Greenwood Fiona , Hoffmann Jan , Goadsby Peter J. 
Published: April 2022

AbstractBackground and purposeChronic migraine is a highly disabling primary headache disorder that is the most common diagnosis of patients seen at tertiary headache centres. Typical oral preventive therapies are associated with many limitations that impact their therapeutic utility. Erenumab was the first available calcitonin gene‐related peptide monoclonal antibody in the UK. It had proven efficacy in migraine prevention in clinical trials and limited real‐world data in tertiary settings.MethodsWe audited our first 92 patients (n = 73 females) with severely disabling chronic migraine who were given monthly erenumab 70 mg sc for 6 months between December 2018 and December 2019.ResultsAt 3 months, monthly migraine days were significantly reduced by a median of 4 days, and all other variables also showed significant improvement. The improvement was not affected by baseline analgesic use status. More than half of our patients experienced a clinically meaningful improvement in migraine days. No serious adverse events were reported.ConclusionsOur real‐world data with erenumab demonstrate it is effective and well tolerated in managing patients with chronic migraine in a tertiary care setting.
Host mixtures for plant disease control: Benefits from pathogen selection and immune priming
Authors: Clin Pauline , Grognard Frédéric , Andrivon Didier , Mailleret Ludovic , Hamelin Frédéric M. 
Published: April 2022

AbstractMultiline and cultivar mixtures are highly effective methods for agroecological plant disease control. Priming‐induced cross protection, occurring when plants are challenged by avirulent pathogen genotypes and resulting in increased resistance to subsequent infection by virulent ones, is one critical key to their lasting performance against polymorphic pathogen populations. Strikingly, this mechanism was until recently absent from mathematical models aiming at designing optimal host mixtures. We developed an epidemiological model to explore the effect of host mixtures composed of variable numbers of single‐resistance cultivars on the equilibrium prevalence of the disease caused by pathogen populations polymorphic for virulence complexity. This model shows that a relatively large amount of resistance genes must be deployed to achieve low disease prevalence, as pathogen competition in mixtures tends to select for intermediate virulence complexity. By contrast, priming significantly reduces the number of plant genotypes needed to drop disease prevalence below an acceptable threshold. Given the limited availability of resistance genes in cultivars, this mechanism of plant immunity should be assessed when designing host mixtures.