bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hertwig's epithelial root sheath cells show potential for periodontal complex regeneration
Authors: Bi Fei , Tang Huilin , Zhang Zhijun , Lyu Yun , Huo Fangjun , Chen Guoqing , Guo Weihua 
Published: August 2022

AbstractBackgroundAlthough researchers have been exploring therapeutic strategies of treating serious periodontal tissue loss, including the application of stem cells, tissue regeneration of the periodontal complex involving cementum, periodontium, and alveolar bone has hardly been achieved. Aiming at tackling the problem of severely damaged periodontal complex, it is worth trying to make advantages of Hertwig's epithelial root sheath (HERS) cells to tissue regeneration mimicking the physiological developmental process with their ability of cementum, bone, and periodontium formation.MethodsHERS cells and dental follicle cells (DFCs) were acquired from Sprague Dawley rats’ molar germs and identified by immunofluorescence. Alizarin red assay, ALP staining, AKP test, real‐time quantitative polymerase chain reaction (RT‐qPCR) and Western blot were conducted to confirm the osteogenic potential, epithelial‐mesenchymal transition (EMT) character of harvested HERS cells and epithelial‐mesenchymal interaction (EMI) with DFCs. An animal model of periodontal defect was constructed to testify the tissue regeneration ability in vivo. Micro‐CT and histological examinations were interpreted to unveil the tissue repair outcomes.ResultsHERS cells expressed strong epithelial cell markers CK14 and E‐cadherin. The in vitro experiments overall showed the concretely enhanced osteogenic differentiation ability in either HERS group or HERS+DFC group. Meanwhile, the in vivo conduction of rat mandibular periodontal repair experiment showed regenerative effectiveness of periodontal complex structure in both HERS and HERS+DFC group in situ, testified by Micro‐CT and histological analysis.ConclusionsHERS cells show potential for periodontal tissue regeneration which suggests the future possibilities of being considered as one of the cell choices for severely damaged periodontal tissue repair.
Elevated preoperative controlling nutritional status (CONUT) scores as a predictor of postoperative recurrence in gastrointestinal stromal tumors
Authors: Yang Weili , Shou Chunhui , Yu Jiren , Wang Xiaodong , Zhang Qing , Yu Hang , Lin Xianke 
Published: August 2022

AbstractBackgroundThe controlling nutritional status (CONUT) score is associated with the postoperative outcomes in various types of tumors, and its prognostic role in gastrointestinal stromal tumors (GISTs) needs to be clarified.MethodsPatients with completely resected primary GISTs in the absence of imatinib adjuvant therapy were included. Recurrence‐free survival (RFS) was estimated with the Kaplan–Meier method and compared using log‐rank test. Prognostic factors were compared using Cox proportional hazards model.ResultsA total of 455 patients were included. The median follow‐up time was 132.0 months (range: 7.0–253.0). Recurrence/metastasis developed in 92 (20.2%) patients. Patients were assigned to three groups: 219 (48.1%) were in normal nutrition group (CONUT = 0–1), 196 (43.1%) were in mild malnutrition group (CONUT = 2–4) and 40 (8.8%) were in moderate–severe malnutrition group (CONUT ≥ 5). Nongastric primary tumor site, large tumor size, high mitotic index, tumor rupture and high CONUT score were independent prognostic factors for shorter RFS using multivariate analysis (p < 0.05).ConclusionsElevated preoperative CONUT score was a predictor of recurrence for patients with resected GIST. The clinical application of the CONUT score is simple and feasible, and might contribute to the individualized treatment of GIST patients.
Allergic Rhinitis Seasonality, Severity, and Disease Control Influence Anxiety and Depression
Authors: Rodrigues Jorge , Pinto João V. , Alexandre Pedro L. , Sousa‐Pinto Bernardo , Pereira Ana M. , Raemdonck Kristof , Vaz Ricardo P. 
Published: August 2022

ObjectivesAllergic rhinitis (AR) has been associated with anxiety and depression. A possible influence of frequency and intensity of the AR symptoms has remained unclear. Therefore, we evaluated the association between AR, as well as its control, seasonality and severity, and the presence of anxiety and depression.MethodsParticipants were selected from a preexistent national database and consecutively contacted by phone. AR was classified according to Allergic Rhinitis and its Impact on Asthma. Presence of anxiety and depression was identified by Hospital Anxiety and Depression Scale (HADS), Beck Anxiety Inventory (BAI), and Beck Depression Inventory‐II (BDI‐II). We built linear regression models assessing the association between any of the assessed anxiety or depression scores and the occurrence, degree of control, seasonality or severity of AR.ResultsWe analyzed 115 participants with AR and 38 participants with no respiratory symptoms. Patients with AR presented higher scores of anxiety (HADS: 3.1; 95% confidence interval [CI] = 1.9; 4.3; p < 0.001) and depression (HADS: 3.8; 95% CI = 2.5; 5.0; p < 0.001). Poorer AR control was positively associated with higher prevalence and scores of anxiety (HADS: 3.0; 95% CI = 1.5; 4.5; p < 0.001) and depression (HADS: 1.8; 95% CI = 0.2; 3.4; p = 0.031). Similar results were obtained with BAI and BDI‐II scales. A moderate/severe presentation of AR were also related with higher scores of anxiety (HADS: 1.7; 95% CI = 0.1; 3.2; p = 0.040) and depression (HADS: 1.7; 95% CI = 0.1; 3.3; p = 0.037).ConclusionThe presence of AR, a poorer control, and a moderate/severe presentation of the disease were significantly associated with higher scores of anxiety and depression. Thus, it is important to alert to this association to allow a quick diagnosis of AR‐associated pathologies. Laryngoscope, 133:1321–1327, 2023
Increasing corrosion resistance of AISI 1010 steel by boride coatings
Authors: Bayça Salih U. , Bican Osman 
Published: August 2022

AbstractBoriding is the process of coating the metal surface with a ceramic metal boride layer by the diffusion method. Iron borides, one of the metal borides, are called ceramics because they are covalently bonded compounds. Iron boride coatings contain strong Fe–B and B–B covalent bonds. In this study, the effect of boronizing on the corrosion resistance of AISI 1010 steel was investigated. Baybora‐1 which has recently been patented was used as boronizing agent. AISI 1010 steel was borided at 950°C for 2, 4, and 6 h using the solid method. The microstructure, hardness, and corrosion rate of the samples were investigated. The change in the corrosion rate of the samples was determined by the corrosion test specified in the ASTM G31‐72 standard. The results showed that the hardness of the iron boride layer formed on the surface as a result of the boronizing process was greater than that of the matrix. As a result of the boriding process, the hardness of the iron boride layer on the steel surface reached approximately eight times the hardness of the substrate matrix. The thickness of the iron boride layer on the steel sample surface was measured at 950°C for 2 and 6 h, respectively, as 45 ± 12 and 155 ± 13 µm. It was concluded that the boriding process increased the corrosion resistance of steel.
Strong Tough Poly Acrylic‐co‐acrylamide Hydrogels via a Synergistic Effect of Fiber and Metal‐Ligand Bonds as Flexible Strain Sensors
Authors: Xiao Longya , Ou Chengjian , Zhang Ding , Ma Yi , Xu Zefeng , Zhou Yitong , Jiang Hongjie 
Published: August 2022

AbstractDeveloping conductive hydrogel‐incorporated strain sensors with high gauge factor (GF) and toughness for wearable applications is challenging. Herein, a facile strategy to fabricate strong, tough polyacrylamide‐co‐acrylic acid [P(AAm‐co‐AAc)] hydrogels via the synergy of fiber and metal‐ligand bonds is proposed. Through the secondary equilibrium approach, the pristine P(AAm‐co‐AAc) gel network is reconstructed with fiber and carboxyl–Zr4+ (Zirconium ion) coordination bonds intertwined over the entire gel matrix, generating a synergistic reinforcement in mechanical properties. The resultant hydrogels display a maximum tensile strength of 8.50 MPa and a fracture energy of 2.75 kJ m−2, which is 1–2 orders of magnitude greater than the original P(AAm‐co‐AAc) gels. It is also experimentally approved that by selecting different natural fibers, multivalent metal ions, and synthetic macromolecules containing carboxyl groups, the proposed approach is effective and can be generalized to fabricate strong, tough gels. Additionally, the electrical properties of obtained gel are evaluated by fabricating it into a stretchable strain sensor for object identification or human motion detection. The results reveal a high GF of 5.07 under a strain smaller 55%. These hydrogels are expected to enable numerous applications in soft robotics or wearable healthcare.
Revisiting power messaging in service failures: Pitfalls and proposed solutions
Authors: Antonetti Paolo , Crisafulli Benedetta 
Published: August 2022

AbstractPast research shows that company messaging can inflate consumers' feelings of power, which in turn alleviate the negative effects of service failures. Extant research, however, has not examined how various types of power messaging can have a differential effect on consumers, with some leading to counterproductive consequences for companies. Across five experiments, we show that power messaging stressing that consumers have power over the company can backfire by increasing manipulative intent. Power messaging communicating that consumers will obtain a power boost from the service is more acceptable and less likely to be perceived as manipulative. Furthermore, we demonstrate that messaging eliciting power from the service is most effective when (1) targeted at consumers with low levels of skepticism, (2) delivered by an underdog brand, and (3) paired with co‐created recovery. Following a service failure, messaging communicating how customers will gain a power boost from the service experience increases identification with underdog brands. Our examination of power messaging as an overt communication strategy contributes to the literature on service failure and recovery. The research advances knowledge of the potential pitfalls of power messaging while proposing strategies to overcome risks associated with this communication strategy.
Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions
Authors: Jiang Yujie , Zhao Tingmei , Zhou Xueyan , Xiang Yu , Gutierrez‐Castrellon Pedro , Ma Xuelei 
Published: August 2022

AbstractThe 2019 coronavirus disease (COVID‐19) pandemic has become a global crisis. In the immunopathogenesis of COVID‐19, SARS‐CoV‐2 infection induces an excessive inflammatory response in patients, causing an inflammatory cytokine storm in severe cases. Cytokine storm leads to acute respiratory distress syndrome, pulmonary and other multiorgan failure, which is an important cause of COVID‐19 progression and even death. Among them, activation of inflammatory pathways is a major factor in generating cytokine storms and causing dysregulated immune responses, which is closely related to the severity of viral infection. Therefore, elucidation of the inflammatory signaling pathway of SARS‐CoV‐2 is important in providing otential therapeutic targets and treatment strategies against COVID‐19. Here, we discuss the major inflammatory pathways in the pathogenesis of COVID‐19, including induction, function, and downstream signaling, as well as existing and potential interventions targeting these cytokines or related signaling pathways. We believe that a comprehensive understanding of the regulatory pathways of COVID‐19 immune dysregulation and inflammation will help develop better clinical therapy strategies to effectively control inflammatory diseases, such as COVID‐19.
Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle
Authors: Djuric Tamara , Kuveljic Jovana , Djordjevic Ana , Dekleva Milica , Stankovic Goran , Stankovic Aleksandra , Zivkovic Maja 
Published: August 2022

AbstractBackgroundMyocardial infarction (MI) leads to ischemia and afterward to left ventricular (LV) remodeling. Matrix metalloproteinase−1 (MMP1) and −3 (MMP3) belong to the family of endopeptidases and together they can dissolve most of the components of the extracellular matrix. MMP1 and MMP3 variants have been investigated solely in association with ischemic heart disease and LV dysfunction, but not in haplotype. The aims of this study were to investigate the association of haplotypes inferred from MMP1 rs1799750 (−1607 1G/2G; NC_000011.9:g.102670497del) and MMP3 rs35068180 (−1612 5A/6A; NC_000011.9:g.102715952dup) with MI and their effect on the change in echocardiographic parameters of LV structure and function in patients within 6 months after MI.MethodsThe study included 325 patients with the first MI and 283 healthy controls. Gene variants were detected by PCR‐RFLP method. Parameters of LV structure and function were assessed by conventional 2D echocardiography, 3–5 days and 6 months after the first MI, on a subgroup of 160 patients. Haplotype analysis was performed with Thesias software.ResultsHaplotypes 2G‐5A and 1G‐6A were significantly and independently associated with MI compared with the reference haplotype 2G‐6A (adjusted, p = 0.009 and p = 0.026, respectively). After Bonferroni correction for multiple testing, MMP1 and MMP3 haplotypes lost their association with the change in LV long diameter and stroke volume within 6 months after MI.ConclusionMMP1 and MMP3 haplotypes are strongly associated with MI. Further studies are needed to validate this result and to examine their association with echocardiographic parameters of LV structure and function after MI.
Time–restricted eating alters the 24‐hour profile of adipose tissue transcriptome in men with obesity
Authors: Zhao Lijun , Hutchison Amy T. , Liu Bo , Wittert Gary A. , Thompson Campbell H. , Nguyen Leanne , Au John , Vincent Andrew , Manoogian Emily N. C. , Le Hiep D. , Williams April E. , Banks Siobhan , Panda Satchidananda , Heilbronn Leonie K. 
Published: August 2022

AbstractObjectiveTime‐restricted eating (TRE) restores circadian rhythms in mice, but the evidence to support this in humans is limited. The objective of this study was to investigate the effects of TRE on 24‐hour profiles of plasma metabolites, glucoregulatory hormones, and the subcutaneous adipose tissue (SAT) transcriptome in humans.MethodsMen (n = 15, age = 63 [4] years, BMI 30.5 [2.4] kg/m2) were recruited. A 35‐hour metabolic ward stay was conducted at baseline and after 8 weeks of 10‐hour TRE. Assessment included 24‐hour profiles of plasma glucose, nonesterified fatty acid (NEFA), triglyceride, glucoregulatory hormones, and the SAT transcriptome. Dim light melatonin onset and cortisol area under the curve were calculated.ResultsTRE did not alter dim light melatonin onset but reduced morning cortisol area under the curve. TRE altered 24‐hour profiles of insulin, NEFA, triglyceride, and glucose‐dependent insulinotropic peptide and increased transcripts of circadian locomotor output cycles protein kaput (CLOCK) and nuclear receptor subfamily 1 group D member 2 (NR1D2) and decreased period circadian regulator 1 (PER1) and nuclear receptor subfamily 1 group D member 1 (NR1D1) at 12:00 am. The rhythmicity of 450 genes was altered by TRE, which enriched in transcripts for transcription corepressor activity, DNA‐binding transcription factor binding, regulation of chromatin organization, and small GTPase binding pathways. Weighted gene coexpression network analysis revealed eigengenes that were correlated with BMI, insulin, and NEFA.ConclusionsTRE restored 24‐hour profiles in hormones, metabolites, and genes controlling transcriptional regulation in SAT, which could underpin its metabolic health benefit.
Xenon‐enhanced computed tomography assessment of brown adipose tissue distribution and perfusion in lean, obese, and diabetic primates
Authors: Garside John C. , Kavanagh Kylie , Block Masha R. , Williams Abigail G. , Branca Rosa T. 
Published: August 2022

AbstractObjectiveThis study aimed to validate xenon‐enhanced computed tomography (XECT) for the detection of brown adipose tissue (BAT) and to use XECT to assess differences in BAT distribution and perfusion between lean, obese, and diabetic nonhuman primates (NHPs).MethodsWhole‐body XECT imaging was performed in anesthetized rhesus and vervet monkeys during adrenergic stimulation of BAT thermogenesis. In XECT images, BAT was identified as fat tissue that, during xenon inhalation, underwent significant radiodensity enhancement compared with subcutaneous fat. To measure BAT blood flow, BAT radiodensity enhancement was measured over time on the six computed tomography scans acquired during xenon inhalation. Postmortem immunohistochemical staining was used to confirm imaging findings.ResultsXECT was able to correctly identify all BAT depots that were confirmed at necropsy, enabling construction of the first comprehensive anatomical map of BAT in NHPs. A significant decrease in BAT perfusion was found in diabetic animals compared with obese animals and healthy animals, as well as absence of axillary BAT and significant reduction of supraclavicular BAT in diabetic animals compared with obese and lean animals.ConclusionsThe use of XECT in NHP models of obesity and diabetes allows the analysis of the impact of metabolic status on BAT mass and perfusion.
Impacts of aphid herbivory on mycorrhizal growth responses across three cultivars of wheat
Authors: Charters Michael D. , Durant Emily K. , Sait Steven M. , Field Katie J. 
Published: August 2022

Societal Impact StatementThe Earth's population is projected to rise to 9.7 billion by 2050 resulting in mounting pressure to increase agricultural yields in a sustainable manner. Arbuscular mycorrhizal (AM) fungi may be important players in this agricultural transition given their capacity to improve soil and plant health. Benefits gained by crops hosting AM fungi can be cultivar‐specific and also affected by insect herbivory, although the combined effect of these factors remains unclear. Here, we show that, in an economically and socially significant tri‐partite system, there is interplay between crop cultivar, AM colonisation and aphid herbivory on plant growth and nutritional status.Summary

Arbuscular mycorrhizal (AM) fungi are critical components of the rhizosphere across nearly all terrestrial biomes. AM fungi associate with most plants, including major crops, usually increasing plant access to soil nutrients and enhancing defence against pests and pathogens in return for photosynthetic carbon (C). However, plant growth responses to AM fungi vary according to species and genotype, an issue pertinent in agro‐ecosystems where crop cultivar can play an important role in AM function. Evidence suggests other biotic interactions, including with sap‐feeding aphids, impact the function of AM symbioses in plants. Nonetheless, whether these biotic factors alter genotype (or cultivar)‐specific plant growth and nutritional responses to colonisation by AM fungi remains unclear.
Here, we investigated whether mycorrhizal responsiveness of three cultivars of wheat (Triticum eastivum L.) to colonisation by a ubiquitously occurring AM fungus (Rhizophagus irregularis) differ in the presence or absence of bird cherry‐oat aphids (Rhopalosiphum padi), a major pest of cereals.
Our findings show that although AM fungal colonisation and AM‐mediated plant growth responses were not affected by aphid feeding, there was variation between cultivars in the benefits gained by host plants in terms of nutrient acquisition and root growth, while aphid abundances also differed between wheat varieties.
Understanding what causes cultivar‐specific outcomes and how they ultimately impact plant growth promotion, crop yields and food production represent key future research goals in agroecology.
Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity
Authors: Wu Anxin , Lu Jing , Zhong Guofeng , Lu Ling , Qu Yan , Zhang Chen 
Published: August 2022

AbstractXanthotoxin (XAT) is a natural furanocoumarins, a bioactive psoralen isolated from the fruit of the Rutaceae plant Pepper, which has received increasing attention in recent years due to its wide source and low cost. By collecting and compiling literature on XAT, the results show that XAT exhibits significant activity in the treatment of various diseases, including neuroprotection, skin repair, osteoprotection, organ protection, anticancer, antiinflammatory, antioxidative stress and antibacterial. In this paper, we review the pharmacological activity and potential molecular mechanisms of XAT for the treatment of related diseases. The data suggest that XAT can mechanistically induce ROS production and promote apoptosis through mitochondrial or endoplasmic reticulum pathways, regulate NF‐κB, MAPK, JAK/STAT, Nrf2/HO‐1, MAPK, AKT/mTOR, and ERK1/2 signaling pathways to exert pharmacological effects. In addition, the pharmacokinetics properties and toxicity of XAT are discussed in this paper, further elucidating the relationship between structure and efficacy. It is worth noting that data from clinical studies of XAT are still scarce, limiting the use of XAT in the clinic, and in the future, more in‐depth studies are needed to determine the clinical efficacy of XAT.
Online monitoring of profiles via function‐on‐scalar model with an application to industrial busbar
Authors: Zhang Wei , Niu Zhanwen , He Zhen , He Shuguang 
Published: August 2022

AbstractIn Statistical Process Control, profile monitoring is used for monitoring whether the process is in‐control or not by checking the relationship stability between the process response and covariates. In the industrial process recently, the functional relationship between the process variables is more and more complex, and the profile data are often time‐dependent and subject to within‐profile autocorrelation. We need to use appropriate models to characterize these complex relationships, and design new profile monitoring schemes to ensure satisfactory process monitoring performance. This paper studies a practical nonparametric profile monitoring problem, in which the functional relationship is in the form of function‐on‐scalar and within‐profile data are autocorrelated. A new online profile monitoring scheme is proposed to monitor process anomalies in real time. In Phase Ⅰ, based on the in‐control historical data, the model for the process is established estimated. Then, using the monitoring statistics based on penalty spline smoothing, the function‐on‐scalar monitoring parameters control scheme with a moving window is presented, and is applied to the anomaly monitoring of online sequential profile data. A large number of numerical simulation results show that in the presence of the function‐on‐scalar relationship, the proposed scheme has a superior performance in various cases. Finally, an application example of industrial busbar running process monitoring is given to illustrate the effectiveness of the scheme.