bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative proteomic analysis of bronchoalveolar lavage fluid in West Highland white terriers with canine idiopathic pulmonary fibrosis
Authors: Maher Rosemary E , Määttä Merita , Beynon Robert J , Laurila Henna P , McNamara Paul S , Rajamäki Minna M 
Published: March 2022

Abstract
Background
Canine idiopathic pulmonary fibrosis (CIPF) is a chronic, progressive, interstitial fibrosing lung disease, manifesting as cough, exercise intolerance and ultimately, dyspnea and respiratory failure. It mainly affects West Highland white terriers (WHWTs), lacks curable treatment and has a poor prognosis. Aspiration of gastroesophageal refluxate may play a role in the development of CIPF. In the first part of this study, we completed label-free quantitative proteomic analysis of bronchoalveolar lavage fluid (BALF) from CIPF and healthy WHWTs. In the second part, we evaluated potential protein markers of reflux aspiration from canine gastric juice and vomitus and whether these were present in BALF from the two groups.

Results
Across all BALF samples, 417 proteins were identified, and of these, 265 proteins were identified by two or more unique tryptic peptides. Using the 265 high confidence assignments, the quantitative proteome profiles were very similar in the two cohorts, but they could be readily resolved by principal component analysis on the basis of differential protein expression. Of the proteins that were differentially abundant in the two groups, several (including inflammatory and fibrotic markers) were elevated in CIPF, and a smaller, more diverse group of proteins were diminished in CIPF. No protein markers indicative of reflux aspiration were identified.

Conclusions
Label-free proteomics allowed discrimination between CIPF and healthy WHWTs, consistent with fibrotic process but did not provide clear evidence for gastrointestinal aspiration. The measurement of proteins may provide a proteomics signature of CIPF that could be used to evaluate treatment options.
Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma
Authors: Li Danyang , Yao Yingcheng , Rao Yuhan , Huang Xinyu , Wei Li , You Zhimei , Zheng Guo , Hou Xiaoli , Su Yu , Varghese Zac , Moorhead John F. , Chen Yaxi , Ruan Xiong Z. 
Published: March 2022

Abstract
Background
Hepatocellular carcinoma (HCC) is one of the most malignant tumors and the fourth leading cause of cancer-related death worldwide. Sorafenib is currently acknowledged as a standard therapy for advanced HCC. However, acquired resistance substantially limits the clinical efficacy of sorafenib. Therefore, further investigations of the associated risk factors are highly warranted.

Methods
We analysed a group of 78 HCC patients who received sorafenib treatment after liver resection surgery. The expression of SCAP and its correlation with sorafenib resistance in HCC clinical samples were determined by immunohistochemical analyses. Overexpression and knockdown approaches in vitro were used to characterize the functional roles of SCAP in regulating sorafenib resistance. The effects of SCAP inhibition in HCC cell lines were analysed in proliferation, apoptosis, and colony formation assays. Autophagic regulation by SCAP was assessed by immunoblotting, immunofluorescence and immunoprecipitation assays. The combinatorial effect of a SCAP inhibitor and sorafenib was tested using nude mice.

Results
Hypercholesterolemia was associated with sorafenib resistance in HCC treatment. The degree of sorafenib resistance was correlated with the expression of the cholesterol sensor SCAP and consequent deposition of cholesterol. SCAP is overexpressed in HCC tissues and hepatocellular carcinoma cell lines with sorafenib resistance, while SCAP inhibition could improve sorafenib sensitivity in sorafenib-resistant HCC cells. Furthermore, we found that SCAP-mediated sorafenib resistance was related to decreased autophagy, which was connected to decreased AMPK activity. A clinically significant finding was that lycorine, a specific SCAP inhibitor, could reverse acquired resistance to sorafenib in vitro and in vivo.

Conclusions
SCAP contributes to sorafenib resistance through AMPK-mediated autophagic regulation. The combination of sorafenib and SCAP targeted therapy provides a novel personalized treatment to enhance sensitivity in sorafenib-resistant HCC.
Can families help veterans get more from PTSD treatment? A randomized clinical trial examining Prolonged Exposure with and without family involvement
Authors: Meis Laura A. , Glynn Shirley M. , Spoont Michele R. , Kehle-Forbes Shannon M. , Nelson David , Isenhart Carl E. , Eftekhari Afsoon , Ackland Princess E. , Linden Erin B. , Orazem Robert J. , Cutting Andrea , Hagel Campbell Emily M. , Astin Millie C. , Porter Katherine E. , Smith Erin , Chuick Christopher D. , Lamp Kristen E. , Vuper Tessa C. , Oakley Taylor A. , Khan Lila B. , Keckeisen Sally K. , Polusny Melissa A. 
Published: March 2022

AbstractBackgroundPosttraumatic stress disorder occurs in as many as one in five combat veterans and is associated with a host of negative, long-term consequences to the individual, their families, and society at large. Trauma-focused treatments, such as Prolonged Exposure, result in clinically significant symptom relief for many. Adherence to these treatments (i.e., session attendance and homework compliance) is vital to ensuring recovery but can be challenging for patients. Engaging families in veterans’ treatment could prove to be an effective strategy for promoting treatment adherence while also addressing long-standing calls for better family inclusion in treatment for posttraumatic stress disorder. This paper describes the methods of a pragmatic randomized controlled trial designed to evaluate if family inclusion in Prolonged Exposure can improve treatment adherence.MethodsOne hundred fifty-six veterans, with clinically significant symptoms of posttraumatic stress disorder, will be randomized to receive either standard Prolonged Exposure or Prolonged Exposure enhanced through family inclusion (Family-Supported Prolonged Exposure) across three different VA facilities. Our primary outcomes are session attendance and homework compliance. Secondary outcomes include posttraumatic stress disorder symptom severity, depression, quality of life, and relationship functioning. The study includes a concurrent process evaluation to identify potential implementation facilitators and barriers to family involvement in Prolonged Exposure within VA.DiscussionWhile the importance of family involvement in posttraumatic stress disorder treatment is non-controversial, there is no evidence base supporting best practices on how to integrate families into PE or any other individually focused trauma-focused treatments for posttraumatic stress disorder. This study is an important step in addressing this gap, contributing to the literature for both retention and family involvement in trauma-focused treatments.Trial registrationClinicalTrials.govNCT03256227. Registered on August 21, 2017.
Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis
Authors: Xiong Anji , Liu Qingting , Zhong Jiaxun , Cao Yuzi , Xiang Qilang , Hu Ziyi , Zhou Shifeng , Song Zhuoyao , Chen Huini , Zhang Yan , Cui Hongxu , Shuai Shiquan 
Published: March 2022

Abstract
Background
Pulmonary hypertension (PH) is a frequent complication of systemic sclerosis (SSc) and is currently one of the primary causes of death in patients with this disease. We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients with SSc to verify trends in mortality in patients with SSc-associated PH.

Methods
We searched the PubMed and Embase databases for published studies on SSc-associated PH from inception to May 2021. All cohort studies in which mortality and/or survival for SSc-associated PH were reported were included in the analysis. The outcome parameters were pooled and analyzed using a random-effects model via generic inverse-variance weighting in conventional and cumulative meta-analysis.

Results
The literature search identified 1161 citations, and the full texts of 54 studies were examined. Sixteen articles, with a total of 7857 patients with SSc and 1140 patients with SSc-associated PH, were included in the meta-analysis. Patients with SSc-associated PH had a higher pooled risk of mortality than patients with SSc without PH (risk ratio = 3.12; 95% confidence interval: [2.44, 3.98]).

Conclusions
This meta-analysis revealed a higher mortality in patients with SSc-associated PH. PH was a significant predictor of death in patients with SSc. Thus, early diagnosis and treatment of PH are important in patients with SSc.
Cold Capitalism: The Political Ecology of Frozen Concentrated Orange Juice
Authors: Hamilton Shane 
Published: March 2022

Abstract
Frozen concentrated orange juice (FCOJ) was invented in 1945 by government researchers. To Florida orange growers beset by surplus production in some years and hard winter freezes in others, FCOJ was a "miracle" technology. Easily stored and transported, concentrate made it possible for orange juice processors to provide consumers with a uniform-quality product year-round. By the mid-1950s constantly rising consumer demand for FCOJ had essentially eliminated Florida orange growers’ constant surplus problem. Furthermore, many oranges that suffered from occasional winter frosts could be transformed into concentrate rather than destroyed. Thus, FCOJ appeared to rationalize the Florida orange industry in the 1950s, eliminating seasonal and annual swings in production and stabilizing prices and profits. However, when severe frosts attacked Florida groves in 1957-58 and again in 1962-63, FCOJ processors responded by doubling prices. Unlike other industrial agriculturists in American history, Florida orange growers and processors did not use technology to control nature in order to increase profits. Instead, they used the environmental limits imposed by Florida’s subtropical climate, along with their oligopolistic market position, to squeeze higher profits out of consumers. They respected the role of nature in limiting their production, not because they were enlightened ecologists, but because their control over orange juice production allowed them to make just as much money from a damaged crop of oranges as from a bumper crop. This case study thus calls into question the meaning of "rationalized" agriculture, showing that the logic of capitalist agriculture is not always straightforward.
Enhancing men's awareness of testicular diseases (E-MAT) feasibility trial: Protocol for a mixed method process evaluation
Authors: Hegarty Josephine , McCarthy Megan , Davoren Martin , Shiely Frances , Harrington Janas M. , Shorter Gillian , Murphy David , Cooke Eoghan , O'Mahony Billy , M. Saab Mohamad 
Published: March 2022

Background: Testicular cancer (TC) is the most common malignancy in men under 50 years. Athletes are particularly at risk of testicular trauma and diseases. Experiencing negative testicular symptoms does not necessarily imply that men seek help. Men’s awareness of testicular diseases is often lacking and their intention to seek help for testicular symptoms is sub-optimal. The use of virtual reality (VR) may be effective in promoting men’s awareness of testicular diseases. The Enhancing Men's Awareness of Testicular diseases (E-MAT) feasibility trial aims to test the effect of E-MATVR (intervention; interactive experience using virtual reality [VR]) compared to information delivered Electronically E-MATE (control; same information as E-MATVR delivered as plain text and images) on testicular knowledge, and testicular self-examination among male athletes affiliated with a national sports organisation. The overall aim of this mixed method process evaluation will be to describe (i) the experiences of participants and key stakeholders (e.g., researchers); (ii) the perceived effectiveness of intervention components; (iii) acceptability of the feasibility trial and intervention procedures; (iv) the relationship between implementation, mechanisms, and context; and (v) the barriers and facilitators to support effective conduct of a future definitive trial. Methods: This mixed method process evaluation will use a descriptive realist evaluation. Quantitative data will be gathered using a usability and satisfaction survey, in addition to fidelity checks during intervention delivery. Quantitative data will be analysed using descriptive and inferential statistics. Qualitative data will be gathered from semi-structured interviews and focus groups with participants and key stakeholders to investigate their experiences of E-MATVR and E-MATE, and explore areas for improvement. Thematic analysis of transcripts will be conducted. Conclusions: This process evaluation will provide an in-depth understanding of how the interventions worked within this cohort and lessons for a future definitive trial.
Achieving QoS for bursty uRLLC applications over passive optical networks
Authors: Roy Dibbendu , Rao Aravinda S. , Alpcan Tansu , Das Goutam , Palaniswami Marimuthu 
Published: March 2022

Emerging real-time applications such as those classified under ultra-reliable low latency (uRLLC) generate bursty traffic and have strict quality of service (QoS) requirements. The passive optical network (PON) is a popular access network technology, which is envisioned to handle such applications at the access segment of the network. However, the existing standards cannot handle strict QoS constraints for such applications. The available solutions rely on instantaneous heuristic decisions and maintain QoS constraints (mostly bandwidth) in an average sense. Existing proposals in generic networks with optimal strategies are computationally complex and are, therefore, not suitable for uRLLC applications. This paper presents a novel computationally efficient, far-sighted bandwidth allocation policy design for facilitating bursty uRLLC traffic in a PON framework while satisfying strict QoS (age of information/delay and bandwidth) requirements. To this purpose, first we design a delay-tracking mechanism, which allows us to model the resource allocation problem from a control-theoretic viewpoint as a model predictive control (MPC) problem. MPC helps in making far-sighted decisions regarding resource allocations and captures the time-varying dynamics of the network. We provide computationally efficient polynomial time solutions and show their implementation in the PON framework. Compared to existing approaches, MPC can improve delay violations by 15% and 45% at loads of 0.8 and 0.9, respectively, for delay-constrained applications of 1 ms and 4 ms. Our approach is also robust to varying traffic arrivals.
Association between city-wide lockdown and COVID-19 hospitalization rates in multigenerational households in New York City
Authors: Ghosh Arnab K. , Venkatraman Sara , Reshetnyak Evgeniya , Rajan Mangala , An Anjile , Chae John K. , Unruh Mark A. , Abramson David , DiMaggio Charles , Hupert Nathaniel 
Published: March 2022

Background
City-wide lockdowns and school closures have demonstrably impacted COVID-19 transmission. However, simulation studies have suggested an increased risk of COVID-19 related morbidity for older individuals inoculated by house-bound children. This study examines whether the March 2020 lockdown in New York City (NYC) was associated with higher COVID-19 hospitalization rates in neighborhoods with larger proportions of multigenerational households.

Methods
We obtained daily age-segmented COVID-19 hospitalization counts in each of 166 ZIP code tabulation areas (ZCTAs) in NYC. Using Bayesian Poisson regression models that account for spatiotemporal dependencies between ZCTAs, as well as socioeconomic risk factors, we conducted a difference-in-differences study amongst ZCTA-level hospitalization rates from February 23 to May 2, 2020. We compared ZCTAs in the lowest quartile of multigenerational housing to other quartiles before and after the lockdown.

Findings
Among individuals over 55 years, the lockdown was associated with higher COVID-19 hospitalization rates in ZCTAs with more multigenerational households. The greatest difference occurred three weeks after lockdown: Q2 vs. Q1: 54% increase (95% Bayesian credible intervals: 22–96%); Q3 vs. Q1: 48% (17–89%); Q4 vs. Q1: 66% (30–211%). After accounting for pandemic-related population shifts, a significant difference was observed only in Q4 ZCTAs: 37% (7–76%).

Interpretation
By increasing house-bound mixing across older and younger age groups, city-wide lockdown mandates imposed during the growth of COVID-19 cases may have inadvertently, but transiently, contributed to increased transmission in multigenerational households.
Laser light sources for photobiomodulation: The role of power and beam characterization in treatment accuracy and reliability
Authors: Girasol Carlos Eduardo , Braz Guilherme de Araújo , Bachmann Luciano , Celli Jonathan , Guirro Rinaldo Roberto de Jesus 
Published: March 2022

Purpose
Daily clinical use of therapeutic light sources can lead to changes in light emission stability with potentially significant consequences for usage in photomedicine treatment. The aim of this study was to evaluate the average and maximum power and to describe the beam diameter of different low-power laser photobiomodulation devices in clinical use in Brazil.

Methods
The power and light-emitting beam diameter of twenty-four therapeutic devices with an average age of 11±5 years, with an average weekly use of fewer than thirty minutes, were measured.

Results
The analyzed power varied between 2% to 134% of the values declared by the manufacturers. Differences in beam diameter of between 38% and 543% of the nominal values were also observed. It is also noteworthy that even between the same brand and model, differences in diameter were obtained. Finally, differences were observed in the power output after one and three minutes of sequential emission for 830 nm and 904 nm (p < 0.05), but not when comparing the difference between wavelengths in factor time.

Conclusion
There is a need for a shared effort on the part of laser manufacturers to improve standardization and consistency of laser output power and beam diameters. At the same time, medical laser operators should also consider development of standardized protocols for maintenance and monitoring equipment performance over time to correct for fluctuations that could ultimately impact on treatment outcomes.
Vidas literarias
Authors: Bermúdez Franco Laura Vivianne , Rojas Melissa , Beltrán Elver 
Published: March 2022

Es difícil encontrar el momento preciso en que uno cruza aquella línea que lleva de la literatura a la realidad y de la realidad a otros mundos. Muchos Hace años tuve la suerte de que mis maestros del colegio me ayudaron a comprender parte de la complejidad que implica ser humano. Debo confesar que en aquella época poco leía, pues, now lo sé, no había comprendido que la literatura era la reunión de muchas vidas contadas de diferentes maneras. Incluso, podría decir que es la vida propia, contada por otros que se escuchan y al escucharse y narrarse nos hablan de lo que somos.Podría aventurarme a decir que aquel acto de cruzar línea se ubica en mis años universitarios, sí, justo en los momentos en que uno siente que por fin ha llegado la vida y por eso le puede poner nombre y forma y color. No sé si hubo algo especial que me vinculara con la lectura y mucho menos que me llevara a intentar escribir. Tampoco puedo decir que un día me levanté viendo pájaros volar entre las letras. Solo puedo comentar, por ahora, que fue la vida hecha vida la que me vínculo con pequeños fragmentos de las palabras que uno jamás diría, pero que ciertamente ha pensado y sentido.
Medicinal plants used in management of certain ailments by the Monpas of Dirang, Arunachal Pradesh, India
Authors: WANGPAN Tonlong , WANGMU Leiki , TANGJANG Sumpam 
Published: March 2022

The Monpas of Arunachal Pradesh, India has rich traditional knowledge on traditional medicines, while, the current study attempts to document the traditional knowledge on the medicinal plants used by them. The field and herbarium techniques were followed to obtain the essential information on the use of medicinal plants. The collected plant species were identified with the consultation of taxonomic literature Floras and Herbaria. Altogether 16 medicinal plant species belonging to 13 families were reported to be used by the Monpa community of this region. Leaves (32%) were the most frequently used plant part, while the flowers (5%) were the least. A total of 16 different medical conditions were reported to be neutralized using these plants. As it was claimed by the locals, these medicinal plants are considered to have no side effects and have multiple health benefits. The plant species Oenanthe javanica, with the highest CIs (Cultural Importance Index) and URs (Use Report) score was reported to be the culturally most significant plant among all the medicinal plants used by the Monpas of this region. Moreover, ICF (Informants Consensus Factor) values specified that there was high agreement in the use of plants in the headache and gastro-intestinal ailments category among the users. The rich bio-resources of this region may be further explored to widen the potentiality of herbal medicines.
Automatically Extracting Surface-Wave Group and Phase Velocity Dispersion Curves from Dispersion Spectrograms Using a Convolutional Neural Network
Authors: Yang Shaobo , Zhang Haijiang , Gu Ning , Gao Ji , Xu Jian , Jin Jiaqi , Li Junlun , Yao Huajian 
Published: March 2022

Abstract
To image high-resolution crustal and upper-mantle structures, ambient noise tomography (ANT) has been widely used on local and regional dense seismic arrays. One of the key steps in ANT is to extract surface-wave group and phase velocity dispersion curves from cross-correlation functions of continuous ambient noise recordings. One traditional way is to manually pick the dispersion curves from dispersion spectrograms in the period-velocity domains, which is very labor intensive and time consuming. Another way is to automatically pick the dispersion curves using some predefined criteria, which are not reliable in many cases especially for phase velocity data. In this study, we propose a novel method named DisperPicker to automatically extract fundamental mode group and phase velocity dispersion curves using a convolutional neural network (CNN). The inputs to CNN include paired group and phase velocity dispersion spectrograms in the period-velocity domains, which are calculated from empirical surface-wave Green’s functions. In this way, group velocity dispersion curves can implicitly guide the extraction of phase velocity dispersion curves, which have large ambiguities to pick on the dispersion spectrograms. The labels or outputs of the network are the probability images converted from dispersion curves. The U-net architecture is adopted because it is powerful for image processing. We have assembled short-period surface-wave data from three different dense seismic arrays to train the network. The trained network is further tested and validated by two datasets close to Chao Lake, China. The tests show that DisperPicker has the generalization ability to efficiently and accurately extract dispersion curves of large datasets without new training.