bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and safety of bee venom pharmacopuncture for rheumatoid arthritis: a systematic review protocol
Authors: Sung Won-Suk , Kim Jung-Hyun , Lee Dong Hyuk , Kim Eun-Jung , Seo Byung-Kwan , Hong Seung-Ug , Baek Yong-Hyeon , Lee Kwang Ho , Kim Joo-Hee 
Published: March 2022

IntroductionRheumatoid arthritis (RA) is the common autoimmune disease with low quality of life. The representative treatment is medication and medication usage has improved through update of clinical guidelines, however, there are still limitations. Bee venom (BV) has been reported to have meaningful therapeutic effects and the possibility of alternative options for RA through several types of studies, but there is no well-organised and recent published systematic review (SR).MethodsWe will search randomised controlled trials about the BV on RA from the inception to 31 May 2022 in various databases, manual research and contacting authors. Electronic databases will include MEDLINE, EMBASE, Cochrane library, China National Knowledge Infrastructure, CiNii, J-STAGE, KoreaMed, Korean Medical Database, Korean Studies Information Service System, National Digital Science Library, Korea Institute of Science and Technology Information and Oriental Medicine Advanced Searching Integrated System. With screening and reviewing process, we will identify the eligible studies and extract the needed data. The primary outcome will be the disease activity scores indicating the improvement of RA symptoms (American College of Rheumatology response criteria 20, 50, 70), functions (Health Assessment Questionnaire, Disease Activity Score of 28 joints), joint (Western Ontario and McMaster universities osteoarthritis index), pain (Visual Analogue Scale, Numerical Rating Scale) and effective rate. The secondary outcomes will be the RA-related blood test levels and adverse events. We will perform a meta-analysis by Review Manager software, the assessment of risk of bias by Cochrane Collaboration ‘risk of bias’ and the determination of quality of evidence by Grades of Recommendation, Assessment, Development and Evaluation.Ethics and disseminationOur SR will suggest the clinical evidence of the use of BV for RA to patient, clinicians and policymakers. We will publish our results in a peer-review journal.PROSPERO registration numberCRD42021238058.
Is there lower utilisation of hospice care services during end-of-life care for people living with HIV? A population-based cohort study
Authors: Chan Shang-Yih , Lai Yun-Ju , Ko Ming-Chung , Chen Yu-Yen , Tsai Yi-Fan , Hsu Li-Fei , Ku Po-Wen , Chen Li-Jung , Chuang Pei-Hung , Chen Chu-Chieh , Yen Yung-Feng 
Published: March 2022

ObjectiveHospice care could improve the quality of life among advanced HIV patients during end-of-life (EOL) treatment. However, providing hospice care services for people living with HIV (PLWH) is challenging due to HIV-related stigma. This nationwide cohort study aims to determine the utilisation of hospice care services among PLWH and HIV-negative individuals during EOL treatment.DesignA retrospective cohort study.SettingFrom 2000 to 2018, we identified adult PLWH from the Taiwan centres for disease control HIV Surveillance System. Individuals who had positive HIV-1 western blots were regarded as HIV-infected. Age-matched and sex-matched controls without HIV infection were selected from the Taiwan National Health Insurance Research Database for comparison. All PLWH and controls were followed until death or 31 December 2018.Participants32 647 PLWH and 326 470 HIV-negative controls were analysed.Primary outcome measuresUtilisation of hospice care services during the last year of life among PLWH and HIV-negative individuals.ResultsA total of 20 413 subjects died during the 3 434 699 person-years of follow-up. Of the deceased patients, 2139 (10.5%) utilised hospice care services during their last year of life, including 328 (5.76%) PLWH and 1811 (12.30%) controls. Adjusting for demographics and comorbidities, PLWH were less likely to receive hospice care services during the last year of life, compared with HIV-negative individuals (adjusted OR: 0.66; 95% CI: 0.57 to 0.75).ConclusionsPLWH had significantly lower utilisation of hospice care services during the last year of life. Our results suggest that future hospice care programmes should particularly target PLWH to increase the optimal utilisation of hospice care services during EOL treatment.
A novel IgG-based FLT3xCD3 bispecific antibody for the treatment of AML and B-ALL
Authors: Mehta Naveen K , Pfluegler Martin , Meetze Kristan , Li Bochong , Sindel Isabelle , Vogt Fabian , Marklin Melanie , Heitmann Jonas S , Kauer Joseph , Osburg Lukas , Zekri Latifa , Bühring Hans-Jörg , Mueller Stefanie , Hörner Sebastian , Baeuerle Patrick A , Michaelson Jennifer S , Jung Gundram , Salih Helmut R 
Published: March 2022

BackgroundIn lymphoid malignancies, the introduction of chimeric antigen receptor T (CAR-T) cells and bispecific antibodies (bsAbs) has achieved remarkable clinical success. However, such immunotherapeutic strategies are not yet established for acute myeloid leukemia (AML), the most common form of acute leukemia in adults. Common targets in AML such as CD33, CD123, and CLEC12A are highly expressed on both AML blasts and on normal myeloid cells and hematopoietic stem cells (HSCs), thereby raising toxicity concerns. In B-cell acute lymphoblastic leukemia (B-ALL), bsAbs and CAR-T therapy targeting CD19 and CD22 have demonstrated clinical success, but resistance via antigen loss is common, motivating the development of agents focused on alternative targets. An attractive emerging target is FLT3, a proto-oncogene expressed in both AML and B-ALL, with low and limited expression on myeloid dendritic cells and HSCs.MethodsWe developed and characterized CLN-049, a T cell-activating bsAb targeting CD3 and FLT3, constructed as an IgG heavy chain/scFv fusion. CLN-049 binds the membrane proximal extracellular domain of the FLT3 protein tyrosine kinase, which facilitates the targeting of leukemic blasts regardless of FLT3 mutational status. CLN-049 was evaluated for preclinical safety and efficacy in vitro and in vivo.ResultsCLN-049 induced target-restricted activation of CD4+ and CD8+ T cells. AML cell lines expressing a broad range of surface levels of FLT3 were efficiently lysed on treatment with subnanomolar concentrations of CLN-049, whereas FLT3-expressing hematopoietic progenitor cells and dendritic cells were not sensitive to CLN-049 killing. Treatment with CLN-049 also induced lysis of AML and B-ALL patient blasts by autologous T cells at the low effector-to-target ratios typically observed in patients with overt disease. Lysis of leukemic cells was not affected by supraphysiological levels of soluble FLT3 or FLT3 ligand. In mouse xenograft models, CLN-049 was highly active against human leukemic cell lines and patient-derived AML and B-ALL blasts.ConclusionsCLN-049 has a favorable efficacy and safety profile in preclinical models, warranting evaluation of its antileukemic activity in the clinic.
The $$D_s^+ \rightarrow \pi ^+ K_S^0 K_S^0 $$ reaction and the $$I=1$$ partner of the $$f_0(1710)$$ state
Authors: Dai L. R. , Oset E. , Geng L. S. 
Published: March 2022

AbstractWe have identified the decay modes of the $$D_s^+ \rightarrow \pi ^+ K^{*+} K^{*-} , \pi ^+ K^{*0} \bar{K}^{*0}$$

D
s
+

→

π
+

K

∗
+

K

∗
-

,

π
+

K

∗
0

K

¯

∗
0

reactions producing a pion and two vector mesons. The posterior vector–vector interaction generates two resonances that we associate to the $$f_0(1710)$$

f
0

(
1710
)

and the $$a_0(1710)$$

a
0

(
1710
)

recently claimed, and they decay to the observed $$K^+ K^-$$

K
+

K
-

or $$K_S^0 K_S^0$$

K
S
0

K
S
0

pair, leading to the reactions $$D_s^+ \rightarrow \pi ^+ K^+ K^- , \pi ^+ K_S^0 K_S^0$$

D
s
+

→

π
+

K
+

K
-

,

π
+

K
S
0

K
S
0

. The results depend on two parameters related to external and internal emission. We determine a narrow region of the parameters consistent with the large $$N_c$$

N
c

limit within uncertainties which gives rise to decay widths in agreement with experiment. With this scenario we make predictions for the branching ratio of the $$a_0(1710)$$

a
0

(
1710
)

contribution to the $$D_s^+ \rightarrow \pi ^0 K^+ K_S^0$$

D
s
+

→

π
0

K
+

K
S
0

reaction, finding values within the range of $$(1.3 \pm 0.4)\times 10^{-3}$$

(
1.3
±
0.4
)

×

10

-
3

. Comparison of these predictions with coming experimental results on that latter reaction will be most useful to deepen our understanding on the nature of these two resonances.
Dynamic RCS Reduction Performances of Antenna Array with Coding Metasurface
Authors: Chen Yan , He Xiao-Xiang , Yang Yang , Hu Heng-Yan , Li Fu-Kang , Yang Lei 
Published: March 2022

On the basis of combining the two concepts of digital coding metasurface and metasurface antenna, low radar cross-section (RCS) coding metasurface antenna array with dynamic scattering performances is presented in this paper. Extending scattering factor theory to coding metasurface antenna, by controlling the states of PIN diodes randomly, the scattering performances of coding metasurface antenna array can be tuned dynamically without degrading its radiation property. Based on phase cancellation principle, a 8

×

8 antenna array was finally simulated and fabricated. By comparing several different layouts, taking checkerboard layout, new chessboard layout, and “0101” square ring nested layout as examples, both monostatic and bistatic RCS of the antenna mentioned above can be reduced 10 dB or more in the frequency range of 9–10.5 GHz under the illumination of x-polarized incident wave. The measured data are consistent with the simulation data, which proves the effectiveness of the proposed method.
Heterogeneity of CAFfeinated Tumors: Sweet Targeting Perspectives
Authors: De Wever Olivier 
Published: March 2022

Abstract
The tumor microenvironment (TME) shows heterogeneity within a tumor. An important element of the TME is cancer-associated fibroblasts (CAF). In this issue of Cancer Research, Bouchard and colleagues investigate the heterogeneity of CAFs from spatially different zones of lung adenocarcinoma resection specimens. Multiomics analysis revealed changes in the O-glycoproteome, unique to CAFs from the tumor edge, an effect reinforced by contact with cancer cells. This O-glycoprotein signature offers unique targeting perspectives that reciprocally affect cancer cell epithelial-to-mesenchymal plasticity, a key mechanism of cancer progression. Deeper understanding of the cancer-stimulating and cancer-inhibiting role of CAF subtypes will facilitate the development of CAF-directed therapeutic approaches.
See related article by Bouchard et al., p. 648
Lithobox: Exploring Hybrid Crafting Practices through a Collaboration across Digital Fabrication and Fine Arts
Authors: Weiler Jennifer , Ingalls Todd , Kuznetsov Stacey 
Published: March 2022

Abstract
New digital and physical fabrication tools are increasingly being integrated with traditional craft techniques to enable hybrid crafting practices. Inspired by the traditional lithophane technique whereby designs are molded in porcelain and visible only when backlit, the authors developed Lithobox: a software system, physical kit and workflow for creating illuminated 3D-printed lithophanes. They explored Lithobox as a creative tool in workshops with nine artists and presented the finished 3D-printed lithophanes and software tool as part of an international art exhibition. Through these collaborations and creative interactions, the authors’ work reveals how the amalgamation of material, technology and productive constraints can influence current art practices.
The Voice of the Century
Authors: Zicari Massimo 
Published: March 2022

The fields of performance studies, empirical musicology, and the musicology of recordings have seen a tremendous development in recent years, shedding new light on the recent history of our performing tradition and conveying essential information to music practitioners, critics and audiences.
This innovative work considers the notion of bel canto and the manner in which this vibrant tradition lives in the records of Luisa Tetrazzini (1871-1940), one of the most celebrated sopranos ever. Tetrazzini, whose discographic career includes about 120 recordings, belongs to that generation of inspirational performers who heralded the dawn of a new era of music appreciation, alongside such iconic figures as Enrico Caruso, Adelina Patti and Nellie Melba.
Drawing on a vast body of scholarship and a number of contemporary reviews, Massimo Zicari establishes Tetrazzini’s role in the Italian operatic tradition and its much disputed set of performing conventions. His transcriptions of her recorded interpretations from Rossini, Donizetti, Bellini and Verdi will prove invaluable to singers and conductors interested in a tradition that goes back to legendary figures such as Jenny Lind and Maria Malibran. The author also discusses her voice quality and technique, tempo flexibility, her use of vibrato and portamento—features of musical performance that question several widely-held, normative views about aesthetics and interpretative tradition.
The volume includes eighty-eight musical examples and its closing section consists of the vocal scores of thirteen operatic arias. The musical material (both examples and transcriptions) is entirely original. This unique approach seeks to combine an academic perspective with the making of the music, in the hope that the plea for originality may be enhanced by models from the past.
Comparative Outcomes for Trauma Patients in Prison and the General Population
Authors: Christian A. B. , Grigorian A. , Mo J. , Yeates E. O. , Dolich M. , Chin T. L. , Schubl S. D. , Kuza C. M. , Lekawa M. , Nahmias J. 
Published: March 2022

Background Prisoners are a vulnerable population, and there are few contemporary studies that consider trauma patient outcomes within the prisoner population. Therefore, we sought to provide a descriptive analysis of prisoners involved in trauma and evaluate whether a healthcare disparity exists. We hypothesized that prisoners and non-prisoners have a similar risk of mortality and in-hospital complications after trauma. Methods The Trauma Quality Improvement Program (2015-2016) was queried for trauma patients based upon location inside or outside of prison at the time of injury. A multivariable logistic regression analysis was performed to compare these groups for risk of mortality—the primary outcome. Results From 593,818 trauma patients, 1115 were located in prison. Compared to non-prisoners, prisoner trauma patients had no significant difference in mortality (5.1 vs 6.0%, P = .204). However, after adjusting for covariates, prisoners had a shorter length of stay (LOS) (mean days, 6.3 vs 7.8, P < .001), shorter intensive care unit (ICU) LOS (mean days, 5.44 vs 5.89, P = .004), and fewer complications, including lower rates of drug/alcohol withdrawal (.4% vs 1.1%, P = .030), pneumonia (.5 vs 1.6%, P = .004), and urinary tract infections (.0 vs 1.1%, P < .001). Upon performing a multivariable logistic regression model, prisoner trauma patients had a similar associated risk of mortality compared to non-prisoners (OR 1.61, CI .52-4.94, P = .409). Discussion Our results suggest that prisoner trauma patients at least receive equivalent treatment in terms of mortality and may have better outcomes when considering some complications. Future prospective studies are needed to confirm these results and explore other factors, which impact prisoner patient outcomes.
Tai Chi Program to Improve Glucose Control and Quality of Life for the Elderly With Type 2 Diabetes: A Meta-analysis
Authors: Wang Yanmei , Yan Jianjun , Zhang Peng , Yang Pei , Zhang Wenhui , Lu Min 
Published: March 2022

Objective To systematically evaluate the effects of Tai chi for improving elderly patients with type 2 diabetes. Methods According to PRISMA checklist, we conducted this standard meta-analysis. The multiple databases like Pubmed, Embase, and Cochrane databases were used to search for the relevant studies, and full-text articles involved in the evaluation of Tai chi in improving elderly patients with type 2 diabetes. Review manager 5.2 was adopted to estimate the effects of the results among selected articles. Forest plots, sensitivity analysis and funnel plot for the articles included were also conducted. Results Finally, 7 relevant studies were eventually satisfied the included criteria. We found that Tai chi group had lower glucose than control group (mean difference (MD)=-12.47, 95%CI [-21.20, −3.73], P=.005; I 2 = 32%), Tai chi group had higher activities-specific balance confidence (ABC) scale than control group (MD =9.26 with 95%CI [6.68, 11.83], P < .001) and Tai chi group had higher single limb standing test score than control group (MD = 8.38, 95%CI [4.02, 12.74], P = .001). The study was robust and limited publication bias was observed in this study. Conclusion Since we found Tai chi had better performance than usual care in improving old diabetes patients' glucose and life quality, the study supports that Tai chi can help old diabetes patients from several aspects including disease indicators, independence and life quality.
The Effects of Osteoarthritis on Depressive Symptomatology Among Older U.S. Military Veterans
Authors: Burant Christopher J. , Graham Gregory C. , Deimling Gary , Kresevic Denise , Kahana Eva , Wykle May , Kwoh C. Kent , Ibrahim Said A. 
Published: March 2022

Osteoarthritis (OA) is a leading cause of disability among older adults. By 2050, approximately 60 million will suffer from arthritis adding up to a total societal cost of $65 billion. Chronic illnesses resulting in pain, and functional decline have been associated with depression in previous studies. A causal model was developed and tested using structural equation modeling that examined depression scores of 503 older (age 50-85), male Veterans with moderate to severe symptomatic OA of the knee\hip. The results of the structural equation modeling produced a final model of depressive symptomatology that fit the data well (Chi square = 12.23, DF = 11, p = .346; TLI = .99; CFI = 1.00; RMSEA = .02). The findings indicate the central role that OA severity (pain, stiffness, and functional difficulties) plays in the mental health of older Veterans in terms of the level of reported depressive symptoms.
Cause of In-Hospital Death After Weaning from Venoarterial-Extracorporeal Membrane Oxygenation
Authors: Bjelic Milica , Kumar Neil , Gu Yang , Chase Karin , Paic Frane , Gosev Igor 
Published: March 2022

Purpose A survival gap between weaning from venoarterial-extracorporeal membrane oxygenation (VA-ECMO) and the hospital discharge has been consistently reported. The aim of this study is to investigate the clinical features of patients who underwent successful VA-ECMO decannulation at our institution and to identify the major contributors responsible for adverse outcomes. Methods We retrospectively reviewed all patients supported with VA-ECMO in our institution between January 2013 and June 2020. Only patients that survived VA-ECMO and underwent successful decannulation were included and dichotomized based on survival to hospital discharge: non-survivors versus survivors. The primary study outcome was the cause of death after successful VA-ECMO decannulation. Results Of the 262 adult patients who underwent VA-ECMO decannulation, 72 (27.5%) patients did not survive to hospital discharge. Non-survivors were older (62 vs. 54 years, p < 0.001) and suffering from many pre-existing comorbidities. Pneumonia and sepsis were the most frequent infectious complication and almost twice as likely in non-survivors. Major causes of death were: cardiovascular (31.9%), infections (25.0%) and neurological (20.8%). The survival curve demonstrated that 51.4% of our patients died within 8 days after decannulation. Multivariate analysis identified older age, central venous cannulation, pulmonary bleeding and infection, dialysis after VA-ECMO, sepsis, and ischemic stroke (OR = 7.86, 95% CI: 2.76-2.43, p < 0.001) as factors significantly predisposing to patients’ death. Conclusion In our study, one-third of patients decannulated off VA-ECMO did not survive to hospital discharge due to end-stage heart failure, infections or neurological injury. The first 8 post-decannulation days were recognized as a critical period where thorough strategies to prevent acquired infections and cautious support of end-organ function should be warranted. Future large-scale trials are needed to confirm our results.
A longitudinal study of the psychological impact of the COVID-19 pandemic on frontline perioperative healthcare staff in an Australian tertiary public hospital
Authors: Ng Irene , Barson Elizabeth , Fisher Caroline , Segal Reny , Williams Daryl L , Krieser Roni B , Mezzavia Paul M , Lee Keat , Chen Yinwei , Sindoni Teresa , Xu Jessica , Lamb Karen , Withiel Toni 
Published: March 2022

Objective This longitudinal study examined changes in psychological outcomes of perioperative frontline healthcare workers at one of Australia’s most COVID-19 affected hospitals, following the surge and decline of a pandemic wave. Method A single-centred longitudinal online survey was conducted between 26 May and 17 November 2020. Recruitment was via poster advertisement and email invitation. The survey was sent out every 4 weeks, resulting in seven time-points. Results In total, 385 survey results were analysed from 193 staff (about 64% response rate), 72 (37%) of whom completed the survey more than once. The prevalence of moderate-to-severe anxiety and depressive symptoms peaked at 27% and 25%, respectively, during the pandemic surge. Up to 35% displayed post-traumatic stress disorder (PTSD) symptoms. Although not statistically significant, the trend of depressive and PTSD symptoms worsened over time, especially among females and anaesthetic/surgical trainees, despite subsidence of the pandemic curve. Technicians and anaesthetic/scrub nurses were the at-risk groups with worst psychological outcomes. Conclusion We found persistent mental health impacts on frontline perioperative HCWs despite subsidence of the pandemic wave. Further research is needed to determine the extent and trajectory of such impacts with larger sample sizes to determine generalisability to frontline HCWs in general.