bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular and phylogenetic characterization of internal transcribed spacer 2 of zoonotic Trichostrongylus species from goats in Bangladesh
Authors: Ahmed Nurnabi , Roy Babul Chandra , Zim Md. Makshuder Rahman , Hasan Mohammad Manjurul , Biswas Hiranmoy , Talukder Md. Hasanuzzaman 
Published: August 2022

Abstract
Trichostrongylus is one of the most economically important and zoonotic trichostrongylid nematode infecting both animals and humans, causing a disease known as trichostrongyliasis. The study was designed to identify Trichostrongylus species infecting goats by morphology-morphometry followed by multiplex PCR and phylogenetic characterization. A total of 124 viscera of goats were collected from different slaughter houses of Mymensingh division of Bangladesh, processed and trichostrongylids were isolated and identified under microscope. Among 124 viscera of goats, 39 were positive with two species of Trichostrongylus, namely, T. colubriformis and T. vitrinus showing an overall 31.45% prevalence. Morphological identification of Trichostrongylus species was confirmed by multiplex PCR amplification of ITS2 gene and sequencing (accession numbers ON721586 to ON721593 for T. colubriformis and T. vitrinus, respectively). Partial sequencing of ITS2 gene of T. vitrinus and T. colubriformis showed 3 and 4 haplotypes, respectively and 7 single nucleotide polymorphisms (SNP) were detected (3 transitions and 4 transversions). The neighbor-joining phylogenetic tree demonstrated that T. colubriformis and T. vitrinus isolates were clustered together with the reference sequences of T. colubriformis and T. vitrinus isolates that belongs to the clade A and B without any geographical boundaries. This is the first report on molecular study and phylogenetic analysis of Trichostrongylus species from goat in Bangladesh. The finding from this study will provide the baseline data for identification, differentiation and phylogenetic analysis of Trichostrongylus species in Bangladesh. Further, extensive investigation is imperative to reveal the population genetics of Trichostrongylus parasite from other livestock and humans of Bangladesh.
Efficient Opportunistic Scheduling Algorithm for Radio Resources Management Multi-Users 5G
Authors: KABAOU Mohamed Ouwais , Mabrouk Nihed , Zoghlami Nesrine , Hamouda Hassen 
Published: August 2022

Abstract
Radio resource management present a major research field in new mobile and wirless networks 5G. The opportunistic scheduling algorithms deployed by mobile telecommunications operators allowing them to guarantee efficient radio resources management. In this context, we propose a new opportunistic scheduling algorithm allowing at the same time to ensure a perfect equity between the users, to guarantee a good QoS and to maximize the overall throughput of the system. We evaluate our proposal, which in turn will be compared to reference algorithms known for their efficiency and robustness in terms of scheduling, namely: RR, MaxSNR and PF. We analyze the impact of diffrent group of users based frainess criterion and system throughput and we compare ou new opportunistic scheduler algorithm wich gives the better results than the optimal algorithm proposed in the literature.
Service quality in rail systems: listen to the voice of social media
Authors: Güner Samet , Taşkın Kamil , Cebeci Halil İbrahim , Aydemir Emrah 
Published: August 2022

Abstract

Service quality is essential to increase and maintain users’ loyalty to the railway system. In the literature, surveys have been used to measure the satisfaction of users, and statistical and mathematical methods have been applied to quantify the survey results. In recent years, user-generated contents, including comments and complaints shared via social media, have been used to measure the quality of rail services. These contents may provide important insights into the quality of the service provided with its dynamic structure. In this study, a SERVQUAL-based social media analytics approach is used to measure railway service quality, paying special emphasis on the temporal variations in a national rail system. Topic modeling was used to assign each content to the relevant service dimension and sentiment analysis was applied to measure the level of satisfaction. Importance-performance analysis was employed at the final stage to generate clear policy suggestions. Gathering more than 2.3 million social media messages posted from 2011 to 2021, we examined the temporal evolution of service quality of the Turkish rail system from users’ points of view. The results revealed the most and least important services for passengers and the satisfaction level of each dimension. The differences between the priorities of conventional and high-speed rail passengers were defined and policy recommendations were presented.
HMGB1/TLR4 Signaling Pathway Enhances Abdominal Aortic Aneurysm Progression in Mice by Upregulating Necroptosis
Authors: Bian Shuai , Yang Le , Zhao Dongfang , Lv Lizhi , Wang Tiezheng , Yuan Hai 
Published: August 2022

Abstract
Objective and design:
The age-associated increase of aseptic inflammation and necroptosis are closely related to the emergence of various age-associated diseases.
Methods
In this study, the role of HMGB1/TLR4-induced necroptosis in abdominal aortic aneurysm (AAA) formation was investigated. Firstly, the levels of sterile inflammatory mediators (HMGB1, TLR4) and necroptosis markers in the abdominal aorta of adult and old C57BL/6J mice were tested. We observed that sterile inflammatory mediators and necroptosis markers were greatly increased in old mice’s abdominal aorta. Then, using angiotensin II (Ang II)-induced AAA model of APOE−/− mice, the models were treated with RIP1 inhibitor Necrostatin-1 (Nec-1), TLR4 inhibitor TAK-242, respectively.
Results
We found that HMGB1, TLR4, and necroptosis markers were elevated with the development of AAA in APOE−/− mice. In addition, necroptosis inhibition by Nec-1 alleviated Ang II-induced AAA development, while the expressions of HMGB1/TLR4 declined. Notably, after blocking TLR4 by TAK-242, the expression of necroptosis markers decreased significantly, and the progression of AAA was also alleviated in APOE−/− mice.
Conclusions
Our results indicate that HMGB1/TLR4-mediated necroptosis enhances AAA development in Ang II-induced AAA model of APOE−/− mice and the possible therapeutic roles for TLR4 inhibition in AAA.
Prediction of Self-management Strategies for Future Quality of life and Health Statuses in Cancer Survivors Using Machine Learning Techniques: A Prospective Cohort Study with a Web-Based Survey
Authors: Jung Ju Youn , Yun Young Ho 
Published: August 2022

Abstract
Purpose: First, we aimed to develop and validate simple prediction models for QoL as a primary outcome and health statuses as secondary outcomes considering the use in actual clinical practice. Second, we aimed to interpret the prediction models using explainable artificial intelligence (XAI) methods by extracting important features and dependence plots. Third, we aimed to predict and interpret individual outcomes and visualize the results using the SHapley Additive explanation (SHAP) XAI method. This study's ultimate goal was to provide customized healthcare services for cancer survivors to improve their QoL and health statuses.Methods: In this prospective cohort study with a web-based survey, we established the prediction model for QoL and health statuses and compared the performance with ensemble methods such as decision trees, random forest, gradient boosting, eXtreme Gradient Boost (XGBoost), and LightGBM. After the model comparison, we selected the XGBoost model for further analysis. We demonstrated critical features of the QoL and each health status separately and extracted the individual prediction result in the XGBoost model using SHAP. Results: After data preprocessing and model selection, the final data set contained 256 cancer survivors with 38 predictive features. On repeated stratified K-fold validation, the XGBoost predictive model for the QoL showed high performance. The performance of the XGBoost predictive model for each health status (mental, social, and spiritual) was also good, except for physical health status. The important features of the above predictive models were different. In addition, our study showed a specific method of providing personalized healthcare services using the individual prediction results with SHAP.Conclusions: This study was the first to develop and validate predictive models for the QoL and health status in cancer survivors, interpret the models, and provide a customized healthcare service with XAI technology. Implications for Cancer Survivors: Our results can contribute to opening a new horizon in providing personalized healthcare services for cancer survivors with a web-based method.
Visual memory and alcohol use in a middle-aged birth cohort
Authors: Mazumder Atiqul Haq , Barnett Jennifer H , Halt Anu-Helmi , Taivalantti Marjo , Kerkelä Martta , Järvelin Marjo-Riitta , Veijola Juha 
Published: August 2022

Abstract
Purpose: Light and moderate alcohol use has been reported to be associated with both impaired and enhanced cognition. The purpose of this study was to explore whether reported alcohol use was associated with reduced visual memory in males and females in a large middle-aged birth cohort population. Methods: The study population was from the Northern Finland Birth Cohort 1966 (NFBC1966). The Paired Associate Learning (PAL) test was conducted at the age of 46 years. Reported alcohol use was measured as gram per day use of total alcohol, beer, wine, and spirits, converted into 100% alcohol, and as frequency and amount of use of beer, wine, and spirits. Data on alcohol use was available at age 31 years and at age 46 years. Visual memory was assessed using two outcome variables of the PAL test: the Total errors adjusted score (TEAS) and First Trial Memory Score (FTMS). Both PAL TEA and PAL FTMS were used as continuous variables. The continuous variables were normalised using z-scores. Linear regression analysis was done to measure the associations. Adjusted models included education, marital status, diet, and physical activity. All analyses were done separately in males and in females. Results: Total alcohol consumption (grams per day) was 17.7 at age 31 years and 13.1 at age 46 years in males. The respective figures for females were 7.2 and 5.1. Grams per day use of total alcohol, beer, wine, and spirits, and frequency and amount of use of beer and wine were not associated with visual memory in males or females in cross-sectional or longitudinal settings. Using six or more servings of spirits was associated with worse visual memory in males in both cross-sectional and longitudinal settings. The frequency of use of wine in males was associated with better visual memory in cross-sectional settings. Conclusion: Most participants reported light drinking. The reported gram per day alcohol use was not associated with reduced visual memory in males or females, with the exception of spirits in males. The study suggests a lack of a linear association between drinking and visual memory in the middle-aged population.
Effects of light intensity and artificial aeration on growth and photosynthetic physiology of marine invasive green alga Codium fragile from Bohai Sea, China
Authors: Ding Lanping , Yan Jing , Zhang Yao , Huang Bingxin , Liang Junxia , Guo Youxuan , Chu Yue 
Published: August 2022

Abstract
Codium fragile has attracted much attention due to its high economic and nutritional values. The light intensity and artificial aeration affect its growth and photosynthetic activity, which in turn affect its economic and nutritional values. The light intensities (30µmol·m− 2·s− 1, 60µmol·m− 2·s− 1, 90 µmol·m− 2·s− 1) and aeration regulation are investigated to the effect on the growth and photosynthetic physiology of C. fragile collected from the Bohai Sea, China. The results show that different light intensities have a highly significant effect on the maximal photochemical efficiency of PSII(Fv/Fm), photochemical quenching coefficient (qP), and a significant effect on the non-photochemical quenching coefficient (NPQ). They all decreased the least under 60µmol·m− 2·s− 1. The increase in the relative growth rate(RGR) of C. fragile during aeration was greater than that of the non-aeration group. At the same time, the Fv/Fm and qP decreased less than those of the non-aeration group. It shows that the aeration regulation had a highly significant effect on the wet weight, Fv/Fm and qP of C. fragile. Among the six groups, only aeration and light intensities of 60 and 90µmol·m− 2·s− 1 were suitable for the growth of C. fragile, because the Fv/Fm decreased less and the qP increased. The result shows that the interaction of the two environmental factors had a significant effect on the Fv/Fm and qP of C. fragile, while there was no significant effect on the wet weight and NPQ.
Compensation Records as an Indirect Method of Assessing Human-wildlife Conflict: A Case Study From Kerala, India
Authors: Issac Christopher John , Prasad G. 
Published: August 2022

Abstract
An analysis of human-wildlife conflict in Kerala was done using compensation claims to evaluate its current status and changes in intensity of conflict incidents over the last seven years. Data was collected from the Kerala Forest and Wildlife Department, from 2015-16 to 2021-22 and included details such as the type of conflict and the number of applications for each type of conflict at different forest ranges of Kerala. There was a sharp rise in the number of applications for compensation, from 6022 applications in 2015-16 to 10036 applications in 2021-22. Highest number of applications for 2019-20 to 2021-22 were from Wayanad North division, Kannur division and Wayanad South division. Moderate positive correlation was found between the total length of forest boundary and the number of applications for compensation.
Customized haptic control for VRML object
Authors: Bijawe Sheetal P. , Sushir R. D. 
Published: August 2022

Abstract
Nonproprietary language like VRML can be used for scientific simulation and visualization. VRML language has the capacity to hold the dynamic numerical values in the matrix form for its interactive objects. These matrices hold the values for manipulation like rotation, scaling, transparency, color, translation etc. Using Simulink’s MATLAB interface, these numeric values can be varied in real time which in turn will allow the user to exercise control over VRML object. The Simulink Graphic User Interface (GUI) demonstrates real time simulation of interactive Virtual Table/Desk Lamp using MATLAB’s Simulink Interface along with Electronic Hardware circuitry. The article explains how interactive VRML object can be controlled using MATLAB’s Simulink interface. The MATLAB’s Simulink capabilities can be utilized for real time simulation of interactive Table/Desk Lamp in virtual Environment. The concept presented in this paper can be extended for full fledged complex simulator design.
A weighted Hardy-type inequality in time scale
Authors: Sahu Sonali , Sunanda Shanta Kumari 
Published: August 2022

Abstract
In this article, we establish some new dynamic inequalities for convex decreasing functions on time scale. A refinement of Hardy type inequality with exponential weight is obtained on time scale. As an application, some higher integrability theorems are derived.MSC Classification: 35A01 , 35A23 , 26D15 , 26E70 , 34N05 , 34N99
Cultivation and conservation of the soft coral Sarcophyton trocheliophorum: Light intensity and photoperiod regulation
Authors: Dong Ruiguang , Li Weidong , Wang Peizheng , Song Xiefa , Li Xian , Dong Dengpan 
Published: August 2022

Abstract
Coral reefs are one of the most diverse, productive ecosystems in the world, and light plays crucial role in its survival. Notably, the effects of light conditions on soft coral and its adaptive mechanism were unclear. Thus, the present study aimed to investigate and evaluate the effects of different light intensities (30, 80 and 130μmol m−2 s−1) and photoperiods (18D:6L, 12D:12L and 6D:18L) on cultivation of soft coral Sarcophyton trocheliophorum. During two 50-day of the experiments, we monitored the zooxanthellae density, Chl a content, enzyme activities (SOD, CAT and GST) and microbial diversity of S. trocheliophorum. Our study's outcomes found that, at the end of the experiment, the 80μmol m−2 s−1 light intensity group and 12D:12L photoperiod group both possessed the highest zooxanthellae density (2.54×108 ± 0.14×108cells g−1 DW and 2.40×108 ± 0.07×108cells g−1 DW, respectively), Chl a content (295.01 ± 14.13µg g−1 DW and 287.78 ± 16.13µg g−1 DW, respectively) and microbial diversity and relatively stable enzyme activities level. Besides, we speculated that the reason for the decline of zooxanthellae density Chl a content and microbial diversity under other light conditions might be that it induced light stress and caused oxidative damage. The main bacterial composition of S. trocheliophorum in different light conditions was similar at the phylum level, showing the stability of microbial community structure. Proteobacteria, Actinobacteria and Firmicutes were dominant under all light conditions, so we hypothesized that these bacteria phylum play a crucial role in coral growth and survival. In conclusion, compared with the other treatments, 80μmol m−2 s−1 light intensity and 12D:12L photoperiod were more beneficial to the growth performance of S. trocheliophorum and could be recommended for its cultivation condition. Our study could provide helpful information for sustainable management plans for the cultivation and conservation of soft corals, which was especially important to the protection and restoration of degraded coral reefs.
A novel laboratory method for simulating pollinator exposure to particulate matter
Authors: Green Frank B , Peterson Eric M , Smith Philip N 
Published: August 2022

Abstract
Deposition of particulate matter (PM) from a variety of sources onto pollinator habitat is a largely unexplored source of risk to pollinators. Synthetic steroid growth promoters, antibiotics, and multiple pesticides have been detected in fugitive beef cattle feedyard PM. Subsequently, many of these chemicals determined to be associated with PM have been detected on flowers near beef cattle feedyards, as well as bees visiting those flowers. Therefore, there is a need to assess risk to pollinators posed by deposition of PM and agrochemical-laden PM, both in the field and the laboratory. Unfortunately, there are no established laboratory methods for simulating PM exposure or toxicity associated with contaminated PM. Herein we describe development and utilization of a PM circulation system that can be employed in the laboratory under controlled conditions. Two model organisms (honeybees (Apis mellifera) and mason bees (Osmia lignaria)) were exposed to agrochemical-free PM in the circulator system, and post-exposure mortality was compared with controls. No significant differences in mortality between exposed and control bees were observed. These results confirm the validity of these methods for use in laboratory-controlled PM exposure experiments, and offer a source of positive and negative control groups for laboratory and field experiments examining exposure of pollinators to potentially toxic chemical-laden PM.
Intratumoral Tertiary Lymphoid Structures Promote Survival and Immunotherapy Response in Head Neck Squamous Cell Carcinoma
Authors: Liu Zhonglong , Meng Xiaoyan , Tang Xiao , He Yue 
Published: August 2022

Abstract
Tertiary lymphoid structures (TLSs) hold the potential role in the prediction of immunotherapy response in several clinical trials. TLSs in head neck squamous cell carcinoma (HNSCC) have been investigated through IHC analysis. Whereas there is no TLS gene signature to evaluate TLS neogenesis. We here proposed a TLS signature containing 13 chemokines and determined TLS-hi and TLS-low groups in HNSCC samples from The Cancer Genome Atlas. TLS-hi condition signified a better overall survival and a more inflamed immune infiltrative landscape characterized by higher proportion of T cells, TCR/BCR activation and antigen processing. Innate lymphoid cells (ILCs) and cancer associated fibroblasts (CAFs) were positively associated with TLS neogenesis in TME of HNSCC. Furthermore, by integrated TLSs with stromal component, immune component, TMB and malignant cells, we proposed a novel HNSCC TME classifications (HNSCC-TCs 1–5), unravelling the counteracted role of stromal component in inflamed immune landscape, which may provide a novel stromal targeted modality in HNSCC therapy. Finally, we verified that TLS statue is an ideal predictor for immune checkpoint blockade immunotherapy. Current study indicated that the TLSs serve as a novel prognostic biomarker and predictor for immunotherapy, which may provide directions to the current investigations on immunotherapeutic strategies for HNSCC.
Stream instabilities in optical-field ionization of a monatomic dilute neutral gas in fully relativistic regime
Authors: Ghorbanalilu Mohammad 
Published: August 2022

Abstract
Stream instabilities arising from anisotropic electron velocity distribution function (EVDF) are discussed in the optical-field ionization mechanism of a monatomic dilute gas by a circularly polarized laser beam in a fully relativistic regime. It is shown that a relativistically rotating electron beam is derived by a circularly polarized laser field with (pz>p⟂). We show that the following ionization and before than collisions thermalize the electrons, the plasma undergoes Buneman and Weibel instabilities. The Weibel and Buneman modes are co-propagating with $k$ normal to the streaming direction. The theoretical results reveal that for the threshold of the relativistic regime (a0\≈1), instabilities are aperiodic and grow independently. However, by increasing the laser intensity for a0>1, two instabilities are coupled. The coupling process increases the growth rate of Weibel instability, while the Buneman instability experiences a decrement in growth rate. For more intense laser radiation, both instabilities are broken into different oscillatory and aperiodic modes.
Transition to renewable energy – An attempt to model the mix of existing and future generation technologies for 2035 and 2050
Authors: Munier Nolberto 
Published: August 2022

Abstract
Pioneered by most advanced countries a global trend is taking place to eliminate fossil fuels (including green natural gas) and in some extent, nuclear plants, for electric energy generation. Part of these efforts aim at improving known and proven technologies such as wind, solar, hydro and biomass, by increasing their efficiency, as well as decreasing the contamination they produce in a greater or a lesser degree. Examining the abundant existent literature on future needs and projections of sources for energy generation, there are certainly publications that estimate the share of each technology, but they are mostly based on estimates grounded mainly on prices and trends. See for instance, Energy Information Agency (EIA) (2019). In this proposal it is suggested that said estimate should not be based only on one or two criteria like prices and contamination, but on a set of multiple criteria, related with economics, society, environment, new technologies, sustainability, efficiency, risks, geographic characteristics, climate change, etc. Consequently, alternatives or technologies should be selected based on this set of criteria, and thus, from different points of view. However, relative evaluation must not be done individually, but considering simultaneously all technologies and the different periods, which is a complicated endeavor. This paper suggests a methodology, based on sound mathematics applied to government plans, as well as forecasted demands, to define the most convenient and efficient mix of technologies for 2035 and 2050.