bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic predisposition to neurodegenerative diseases and risk of stroke: A Mendelian randomization study
Authors: Li Fuju , Wang Yunyun , Hou Xiaoyan , Cao Lina , Zhou Xiaoyi , Yuan Weiyan , Shen Yi , Tian Tian 
Published: November 2022

BackgroundTraditional epidemiological studies suggested that Neurodegenerative diseases (ND) might correlate with stroke. We intend to explore whether the two most common neurodegenerative diseases [Alzheimer’s disease (AD) and Parkinson’s disease (PD)] are causally associated with stroke and its subtypes.MethodsTwo-sample Mendelian Randomization (MR) method was used to explore the causal relationships. Candidate genetic instrumental variables (IVs) for AD and PD were collected from the genome-wide association studies (GWAS) in European populations. The inverse-variance weighted (IVW) method was the primary method of MR analysis, and the weighted median method was supplementary. In addition, the MR-Egger method and the MR-PRESSO test were used as well.ResultsWe found no causal effects of AD on stroke, Ischemic stroke (IS), or Intracerebral hemorrhage (ICH). As for PD and stroke, our preliminary results showed PD could causally influence the risk of stroke [odds ratio (OR): 1.04; 95% confidence interval (CI): 1.02–1.07; P = 0.001 by the IVW method], although the alternative method did not support this result. We identified the positive causal relationship between PD and the risk of IS (OR = 1.04; 95% CI: 1.02–1.07; P = 0.001 by the IVW method), and the alternative MR methods produced similar results. The present study found there was no causal relationship between PD and ICH.ConclusionThis study found a causal relationship between genetic susceptibility to PD and the incidence of stroke (especially IS) in the European population; however, there was no causal relation between AD and stroke risk.
Risk of dementia or Parkinson’s disease in the presence of Sjögren’s syndrome: A systematic review and meta-analysis
Authors: Wang Zhen-Zhi , Liu Meng-Si , Sun Zhen , Zhang Xu-Long , Zhang Mei-Ling , Xiong Kang , Zhou Feng 
Published: November 2022

ObjectiveEvidence from observational studies suggests that Sjögren’s syndrome (SS) may contribute to an elevated risk of Parkinson’s disease (PD) and dementia. However, few studies have been undertaken to summarize and assess the consistency of the data quantitatively. Therefore, we evaluated the risk of dementia and PD in SS patients through a systematic review and meta-analysis approach.MethodsTwo reviewers independently conducted a systematic search of PubMed, Embase, and Web of Science databases (updated to February 14, 2022) to identify published literature on the association between SS and dementia or PD. The risk estimates of dementia or PD in patients with SS were pooled using fixed or random-effects models.ResultsOf the 631 studies initially searched, 10 were eventually included. Pooled results suggested that the risk of developing dementia significantly increased in patients with SS (HR = 1.24, 95% CI: 1.15–1.33, P &lt; 0.001), and such risk in females with SS was similar to that in males. The risk of PD was 1.36 times higher in SS (HR = 1.36, 95% CI: 1.23–1.50, P &lt; 0.001). The association between SS and PD risk appeared to occur primarily in female patients (female: HR = 1.28, 95% CI: 1.21–1.35; P &lt; 0.001 vs. male: HR = 1.00, 95% CI: 0.87–1.16, P = 0.962, respectively). No significant effect of age was observed on the risk of developing PD and dementia in SS patients.ConclusionOur study supports that people with SS are at higher risk of PD and dementia than the general population. Further studies are needed to elucidate the underlying mechanisms and to assess whether interventions for SS have the potential to affect dementia and PD development.
Case Report: MAP2K1 K57N mutation is associated with primary resistance to anti-EGFR monoclonal antibodies in metastatic colorectal cancer
Authors: Mauri Gianluca , Patelli Giorgio , Gori Viviana , Lauricella Calogero , Mussolin Benedetta , Amatu Alessio , Bencardino Katia , Tosi Federica , Bonazzina Erica , Bonoldi Emanuela , Bardelli Alberto , Siena Salvatore , Sartore-Bianchi Andrea 
Published: November 2022

BackgroundWe aim to identify the prevalence and the role of the MAP2K1 K57N mutation in predicting resistance to anti-EGFR agents in metastatic colorectal cancer (mCRC) patients.MethodsWe retrospectively reviewed tumor-based next generation sequencing (NGS) results from mCRC patients screened for enrollment in the GO40872/STARTRK-2 clinical trial between July 2019 and March 2021. Then, in patients harboring microsatellite stable (MSS) RAS and BRAF wild-type MAP2K1 mutant mCRC, we reviewed outcome to treatment with anti-EGFR monoclonal antibodies.ResultsA total of 246 mCRC patients were screened. Most of them, 215/220 (97.7%), were diagnosed with MSS mCRC and 112/215 (52.1%) with MSS, RAS and BRAF wild-type mCRC. Among the latter, 2/112 (1.8%) had MAP2K1 K57N mutant mCRC and both received anti-EGFR monotherapy as third line treatment. In both patients, MAP2K1 K57N mutant tumors proved primary resistant to anti-EGFR agent panitumumab monotherapy. Of interest, one of these patients was treated with anti-EGFR agents three times throughout his course of treatment, achieving some clinical benefit only when associated with other cytotoxic agents (FOLFOX or irinotecan).ConclusionWe verified in a clinical real-world setting that MAP2K1 K57N mutation is a resistance mechanism to anti-EGFR agents in mCRC. Thus, we suggest avoiding the administration of these drugs to MSS RAS and BRAF wild-type MAP2K1 N57K mutant mCRC.
Physiological effects of γ-aminobutyric acid application on cold tolerance in Medicago ruthenica
Authors: Li Ying , Yu Xiaojun , Ma Kaikai 
Published: November 2022

Low temperatures in the seedling stage during early spring limit Medicago ruthenica germination and seedling growth. Elucidating the physiological mechanism of γ-aminobutyric acid (GABA)-regulated cold tolerance in M. ruthenica could provide a reference for alleviating the harmful effects of low temperatures on legumes in alpine meadows. The regulatory effects of GABA on M. ruthenica physiological parameters were explored by simulating the ground temperatures in the alpine meadow area of Tianzhu, China, in early May (2 h at 7°C; 6 h at 15°C; 4 h at 12°C; 2 h at 7°C; 10 h at 3°C). Our results showed that 15 mmol/l GABA was the optimal spray concentration to promote growth in the aboveground and belowground parts and increase the fresh and dry weights of seedlings. At this concentration, GABA enhanced the activities of catalase, peroxidase, superoxide dismutase, and ascorbate peroxidase; increased the osmotic balance; and inhibited the production of harmful substances in the cells under low-temperature conditions. GABA also regulated the tissue structure of leaves, increased the cell tense ratio, maintained photochemical activity, increased the amount of light energy to the photochemical reaction center, and improved the photosynthetic rate. Furthermore, exogenous GABA application increased the endogenous GABA content by promoting GABA synthesis in the early stages of low-temperature stress but mainly participated in low-temperature stress mitigation via GABA degradation in the late stages. Our results show that GABA can improve the cold tolerance of M. ruthenica by promoting endogenous GABA metabolism, protecting the membrane system, and improving the leaf structure.
Experience of nature and times of silence as a resource to cope with the COVID-19 pandemic and their effects on psychological wellbeing—Findings from a continuous cross-sectional survey in Germany
Authors: Büssing Arndt , Recchia Daniela Rodrigues , Baumann Klaus 
Published: November 2022

BackgroundThe COVID-19 pandemic with its lockdowns affected social relations and mental health conditions of people worldwide. We aimed to analyze the relevance of nature and times of silence as resources to cope with the pandemic. Of interest were how experiences of nature and times of silence are related to the perception of wondering awe and gratitude and psychological wellbeing and how these have changed during the different phases of the pandemic. Finally, we asked whether Nature/Silence would mediate the link between Awe/Gratitude and wellbeing.MethodsA cross-sectional survey with standardized questionnaires (i.e., PCQ, GrAw-7, BMLSS-10, WHO-5) enrolling participants during the different phases of the COVID-19 pandemic was conducted. The total sample of 5,155 participants from Germany consisted of 65% women and 34% men, with a mean age of 45.0 ± 14.0 years.ResultsDirectly after the first lockdown, Nature/Silence and Awe/Gratitude scores were high and decreased along with wellbeing with the onset of the second lockdown in winter 2020, while perceived burden constantly increased. Nature/Silence was rated lowest by people with reduced wellbeing (eta2 = 0.058) and feeling lonely or socially isolated (eta2 = 0.042). Predictor analyses revealed that wellbeing as a dependent variable was predicted best by corona-related perception of burden, Awe/Gratitude, reflection of life, and Nature/Silence and further by perceived changes in terms of relationships and spirituality (R2 = 0.55). In mediation analyses, Awe/Gratitude proved to be a significant predictor for Nature/Silence (β = 0.55, p&lt; 0.0001) and wellbeing (β = 0.05, p &lt; 0.0001). The mediation analysis explained 37% of the variability in the data. The direct influence of Awe/Gratitude on wellbeing was estimated as β = 0.09 (p &lt; 0.0001), and the mediation effect of Nature/Silence on the link between Awe/Gratitude and wellbeing was significant, too (β = 0.03, p &lt; 0.0001), explaining 25% of the total effect.ConclusionNature/Silence and Awe/Gratitude were used as relevant resources during the pandemic, although they cannot fully buffer the negative effects of the social restrictions that resulted in decreases in wellbeing and increases in perceived burden. Perception of nature as a sensitizer of positive experiences particularly during difficult phases of life could be trained to stabilize wellbeing and thus to contribute to public health.
Changing trends of patient characteristics and treatment pathways during the COVID-19 pandemic: A cross-sectional analysis of 72,459 inpatient cases from the German Helios database
Authors: König Sebastian , Hohenstein Sven , Pellissier Vincent , Leiner Johannes , Hindricks Gerhard , Nachtigall Irit , Kuhlen Ralf , Bollmann Andreas 
Published: November 2022

BackgroundThis study compared patient profiles and clinical courses of SARS-CoV-2 infected inpatients over different pandemic periods.MethodsIn a retrospective cross-sectional analysis, we examined administrative data of German Helios hospitals using ICD-10-codes at discharge. Inpatient cases with SARS-CoV-2 infection admitted between 03/04/2020 and 07/19/2022 were included irrespective of the reason for hospitalization. All endpoints were timely assigned to admission date for trend analysis. The first pandemic wave was defined by change points in time-series of incident daily infections and compared with different later pandemic phases according to virus type predominance.ResultsWe included 72,459 inpatient cases. Patients hospitalized during the first pandemic wave (03/04/2020–05/05/2020; n = 1,803) were older (68.5 ± 17.2 vs. 64.4 ± 22.6 years, p &lt; 0.01) and severe acute respiratory infections were more prevalent (85.2 vs. 53.3%, p &lt; 0.01). No differences were observed with respect to distribution of sex, but comorbidity burden was higher in the first pandemic wave. The risk of receiving intensive care therapy was reduced in all later pandemic phases as was in-hospital mortality when compared to the first pandemic wave. Trend analysis revealed declines of mean age and Elixhauser comorbidity index over time as well as a decline of the utilization of intensive care therapy, mechanical ventilation and in-hospital mortality.ConclusionCharacteristics and outcomes of inpatients with SARS-CoV-2 infection changed throughout the observational period. An ongoing evaluation of trends and care pathways will allow for the assessment of future demands.
Effectiveness and feasibility of self-sampling for human papillomavirus testing for internet-based cervical cancer screening
Authors: Li Jingran , Wu Ruifang , Qu Xinfeng , Huang Xia , Li Ling , Lin Zhixin , Zhang Zhijun , Deng Jihong , Liu Rong , Zhao Xiaofeng , Zhang Songling , Lin Bei , An Ruifang , Zhao Chao , Li Mingzhu , Zhao Yun , Wei Lihui 
Published: November 2022

ObjectivesWorldwide, around 18.2% of cervical cancer occurred in China, mainly because of lower screening coverage and screening quality in regional disparities. To assess self-sampling for human papillomavirus (HPV) testing, combined with the internet, as a primary cervical cancer screening (CCS) method in low-resource settings, and to establish an internet-based self-sampling CCS-management model.MethodsThe women who participated registered on a CCS website. We recruited 20,136 women, aged 30–59 years, from 13 provinces in China, to perform vaginal self-sampling for HPV testing as a primary CCS, based on the internet. A questionnaire was subsequently used to investigate the acceptability of self-sampling.ResultsOf the 20,103 women with qualified samples, 35.80% lived in remote areas, 37.69% had never undergone CCS, 59.96% were under-screened, and the overall prevalence of a high-risk of HPV was 13.86%. Of 8,136 respondents, 95.97% of women felt that self-sampling was easy to perform, 84.61% had no discomfort when using a self-sampling brush, 62.37% women were more likely to choose self-sampling for CCS in future, and 92.53% were willing to introduce the concept to others around them. The reliability and ease of self-sampling were independent factors influencing selection of self-sampling (p &lt; 0.05).ConclusionsThe Internet-facilitated self-sampling for HPV testing and management model for cervical cancer prevention is feasible and effective. It can be used as a supplement to the conventional screening, particularly in outlying areas with few medical resources, to improve the coverage of CCS.Clinical trial registrationhttps://www.chictr.org.cn, identifier: ChiCTR2000032331.
“famílias que escolhemos” pelo Facebook
Authors: Woltmann Figueiró Lucas 
Published: November 2022

O presente escrito trata da “Inseminação Caseira” em seres humanos. Diferente do que ocorre em clínicas e centros profissionais de reprodução assistida, sob o rótulo de Inseminação Caseira repousam alternativas informais e caseiras para a reprodução e constituição de arranjos familiares. Apoiado em materiais diversos (grupos temáticos na plataforma Facebook, reportagens, documentos e vídeos na plataforma YouTube), o objetivo deste artigo é analisar os modos pelos quais essa alternativa reprodutiva tem sido apresentada e que contribuições agrega para pensarmos temas tratados sob as rubricas parentesco, ciência e tecnologia. Para tal, intelectuais como Kath Weston, Marilyn Strathern, Charis Thompson e Claudia Fonseca foram consultadas como fonte de inspiração. Aliadas e outras referências que cito de forma pontual, essas intelectuais fornecem a grade teórica por meio da qual tento compreender a Inseminação Caseira e algumas de suas particularidades. As análises realizadas sugerem que, nas escolhas e práticas levadas adiante na busca pelo “sonho” da maternidade, tentantes e doadores negociam laços de pertencimento. Para tal, atuam tanto “naturalizando” aspectos que escapam de laços biogenéticos, quanto negando o que poderia ser considerado natural e irrevogável. Se em alguns momentos se atribui mais ênfase ou valor a aspectos biogenéticos, isso não impede que, de forma simultânea e proporcional, se invista na produção de outras tantas formas de conexão e pertencimento.
The Relationship of the Quality Dimensions of Antenatal Care Services with the Satisfaction of Pregnant Women in Trimester Iii in the Work Area in the Hutabayu Puskesmas, Simalungun Regency in 2021
Authors: Nurmawan Siti 
Published: November 2022

Service quality can be measured by comparing the perception of the expected service with the service received and felt by the patient. Patient satisfaction is the level of the patient's feelings after comparing with his expectations. If a patient is satisfied with the value provided by the product or service, he is very likely to become a customer for a long time. Indirect factors that cause high maternal and infant mortality rates include the low level of mother's knowledge and the irregular frequency of Ante Natal Care examinations. Ante Natal care is a service provided to pregnant women on a regular basis to maintain the health of the mother and baby. Quality Ante Natal Care services can increase public trust and satisfaction with health services provided by midwives and Puskesmas.
Satisfaction is a human who has compared in terms of performance and also the expected results through the level of one's feelings. In another theory written by Wilton, it is stated that satisfaction or dissatisfaction is the result of the final evaluation of the customer response, namely the suitability that has been felt by the customer with the expectation that the performance of the product can be felt after the customer uses it. (Abarca 2020)
Mise en lumière du marketing digital des sites américains de réservation d’hébergements via les travaux de Cialdini
Authors: Martin Élodie 
Published: November 2022

Cet article vise à analyser le marketing digital des sites américains de réservation d’hébergements Booking.com, Expedia et Hotels.com. Nous proposons de montrer que les professionnels du marketing de ces sites optent pour les techniques de persuasion telles que la réciprocité, l’engagement et la cohérence, la preuve sociale, la sympathie, l’autorité ainsi que la rareté, mises en lumière par R. Cialdini [2006]. Ces stratégies se manifestent linguistiquement et extralinguistiquement, ce qui justifie notre souhait de proposer une analyse multimodale. Nous notons leur présence dans la présentation des sites ainsi que dans celle des offres lors de recherches d’hébergements fictives à Londres et New York, pour les périodes du 28 juillet 2019 au 10 août 2019 et du 28 août 2019 au 10 septembre 2019.
Les stratégies de persuasion multimodales du discours marketing dans le domaine des cosmétiques (français-anglais)
Authors: Bordet Lucile , Jamet Denis 
Published: November 2022

Les techniques argumentatives de persuasion dans le discours publicitaire des cosmétiques pour hommes et pour femmes, en français et en anglais, sont abordées dans le cadre de cette étude. Ce travail poursuit la réflexion initiée lors d’une première étude des stratégies linguistiques et non linguistiques de persuasion, afin de déterminer si des stratégies spécifiques sont mises en œuvre selon la langue ou le genre du public visé. Un corpus de 342 publicités est analysé par le prisme du choix des thématiques, mais aussi des couleurs, effectué par les publicitaires. Les conclusions de l’étude montrent, aussi bien au niveau de la langue qu’au niveau du genre du public visé, que les thématiques abordées (jeunesse, vieillesse, masculinité, virilité, etc.) ainsi que les couleurs utilisées selon les genres ciblés jouent un rôle argumentatif. Cette étude a également montré que les thématiques, tout comme les couleurs, jouent un rôle à la fois dans le renforcement des stéréotypes liés au genre, mais aussi dans la persuasion des consommateurs et consommatrices. Ceci semble particulièrement vrai pour un public cible masculin pour lequel le choix des couleurs apparaît plus persuasif que pour un public féminin.
Poésie et imprimerie : les notes d’Alfred de Vigny
Authors: Dupuy Pierre 
Published: November 2022

La poésie d’Alfred de Vigny a la réputation, peut-être plus qu’une autre, d’être tournée vers l’histoire. La raison en est qu’elle ne raconte pas l’histoire seulement sur un mode narratif, mais qu’elle fait l’effort de se penser historiquement. Poser la question du rapport entre poésie et imprimerie, c’est de ce fait s’interroger sur les difficultés que connaît la parole poétique à être au monde historiquement. L’histoire étant par excellence le lieu de l’écrit et du récit, cet article vise à mettre en évidence un antagonisme plus ou moins prononcé entre l’oral et l’écrit, le chant et la technique.
The EFFECT OF UNDERSTANDING TAX REGULATIONS, APPLICATION OF TAXATION E-SYSTEMS, AND THE ROLE OF ACCOUNT REPRESENTATIVES ON TAXPAYER COMPLIANCE WITH PERSONAL PERSON
Authors: Laksmi P Kadek Wulandari , Ariwangsa I G. N.O. , Lasmi Ni Wayan , Tatwa Ida Ayu Ratih Dharmayanti 
Published: November 2022

T The aims of this study was to determine the impact of understanding tax regulations, the application of the taxation e-system, and the role of account representatives on individual taxpayer compliance. The population in this study is the taxpayer of KPP Pratama Denpasar Timur. Determination of the number of samples using the Slovin formula with random sampling in order to obtain as many as 100 samples. Multiple linear regression analysis was used to analyze the data in this study. The results showed that the understanding of tax regulations, the application of the taxation e-system and account representatives had a positive and significant effect on the compliance of taxpayers in carrying out their tax obligations. This shows that the better the understanding of taxpayers on tax regulations, the implementation of the e-system of taxation and account representative services will be able to increase the compliance of taxpayers in carrying out their tax obligations at KPP Pratama Denpasar Timur
Rate Loss due to Beam Cusping in Grid of Beams
Authors: Tiwari Krishan Kumar , Caire Giuseppe 
Published: November 2022

<p>We present mean communication rate loss (MCRL) values due to the beam cusping phenomenon inherent to grid of beams based wireless systems, which are widely used/proposed in millimeter-wave and sub-THz bands. We consider array antenna elements with non-zero aperture and axisymmetric radiation pattern with a certain directivity, unlike the ideal isotropic antenna elements widely considered in theoretical papers on array processing and RF beamforming. The array antenna elements have a half power beam width of ninety degrees in this work which is typical of commonly used microstrip patch antenna elements. We perform Monte Carlo numerical experiments to obtain MCRL values for different spatial dimensions of multiple input multiple output (MIMO) systems, different angular fields-of view, and different beamforming codebook sizes. We show that increasing the beam grid density beyond a certain threshold does not help and therefore a certain cusping loss is unavoidable even for continuous beam steering with directive antenna elements. Further, we also show the quantitative impact on the MCRL values as the axisymmetric radiation pattern directivity of the modelled antenna element is increased.</p>
Neoadjuvant Nivolumab and Ipilimumab for Nonmetastatic Renal Cell Carcinoma with Tumor Thrombus
Authors: Master Viraj A. , Schmeusser Benjamin N. , Osunkoya Adeboye O. , Palacios Arnold R. , Midenberg Eric , Yantorni Lauren , Ogan Kenneth , Bilen Mehmet A. 
Published: November 2022

ABSTRACT
Renal cell carcinoma with level IV tumor thrombus is a condition necessitating aggressive surgical management. Many solid organ malignancies often benefit from neoadjuvant treatments for tumor debulking and improvement of surgical outcomes. However, neoadjuvant treatments for renal cell carcinoma have been limited by its resistance to traditional chemotherapy and radiation. Emerging treatment modalities, such as immunotherapies, are exciting new options that may be therapeutically effective. The combination of nivolumab and ipilimumab has exhibited success in managing metastatic renal cell carcinoma. Limited data exist for its use in nonmetastatic renal cell carcinoma with tumor thrombus. This case illustrates the use of nivolumab and ipilimumab combination therapy in delaying tumor growth, producing observable tumor thrombus histologic and radiologic treatment changes, and, most importantly, facilitating a less invasive surgical approach of a level IV renal cell carcinoma tumor thrombus.