bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doxycycline Postexposure Prophylaxis and Sexually Transmitted Infection Trends
Authors: Sankaran Madeline , Glidden David V. , Kohn Robert P. , Nguyen Trang Q. , Bacon Oliver , Buchbinder Susan P. , Gandhi Monica , Havlir Diane V. , Liebi Courtney , Luetkemeyer Anne F. , Nguyen Janet Q. , Roman Jorge , Scott Hyman , Torres Thiago S. , Cohen Stephanie E. 
Published: January 2025

ImportanceIncreasing rates of sexually transmitted infections (STIs) have been associated with rises in serious morbidity. While doxycycline postexposure prophylaxis (doxyPEP), a strategy in which individuals take doxycycline, 200 mg, after condomless sex to prevent bacterial STIs, has been shown to be efficacious in randomized clinical trials, doxyPEP’s potential effect on population-level STI incidence is unknown.ObjectiveTo assess the association of citywide doxyPEP guideline release with reported chlamydia, gonorrhea, and early syphilis cases in men who have sex with men (MSM) and in transgender women in San Francisco, California.Design, Setting, and ParticipantsThis population-level interrupted time series analysis of reported San Francisco STI cases measured monthly cases of chlamydia, gonorrhea, and early syphilis prior to (July 2021-October 2022) and after (November 2022-November 2023) release of citywide doxyPEP guidelines in October 2022. All reported chlamydia, gonorrhea, and early syphilis cases among MSM and transgender women in San Francisco during the period of analysis were included. Data were analyzed November 2023 to July 2024.ExposureRelease of doxyPEP citywide guidelines.Main Outcomes and MeasuresThe primary outcome was the percentage change between projected and observed chlamydia, gonorrhea, and early syphilis cases in the 13-month postexposure period.ResultsCitywide, there were 6694 cases of chlamydia, 9603 cases of gonorrhea, and 2121 cases of early syphilis among MSM and transgender women during the analytic period. STI cases among MSM and transgender women decreased significantly compared with model projections for chlamydia (−6.58% per month; 95% CI, −7.99% to −5.16%) and early syphilis (−2.68% per month; 95% CI, −3.75% to −1.60%) after doxyPEP implementation. By the end of the 13-month postperiod in November 2023, chlamydia and early syphilis cases decreased −49.64% (95% CI, −59.05% to −38.06%) and −51.39% (95% CI, −58.21% to −43.46%), respectively, compared with projected cases. There was a significant increase in monthly gonorrhea cases compared with projections (1.77% per month; 95% CI, 0.87% to 2.67%).Conclusions and RelevanceThis study suggests that San Francisco’s doxyPEP guideline release was associated with decreases in reported cases of chlamydia and early syphilis, but not gonorrhea, among MSM and transgender women in San Francisco. Further analyses are needed to assess whether declines are sustained and monitor for adverse consequences, including antimicrobial resistance. Supporting doxyPEP implementation for MSM and transgender women at risk for STIs could have a significant impact on the nationwide STI epidemic.
Enhancing Lithium‐Mediated Nitrogen Reduction with Porous Polymer Fibers Featuring Lithium‐Ion Affinity
Authors: Shin Dongwoo , Choi Ahee , Han Dong‐Yeob , Bak Gwangsu , Yoo Suhwan , Jeon Yeongbae , Park Soojin , Hwang Yun Jeong 
Published: January 2025

AbstractThe interaction between the electrolyte and working electrode surface affects the cascade of reactions involving Li deposition, N2, and proton carriers and consequently the NH3 production from Li‐mediated nitrogen reduction reaction (Li‐NRR). Efficient Li‐NRR at low Li concentrations is particularly challenging because of low current density and uneven Li metal and lithium nitride plating. Here, the enhanced electrochemical production of NH3 for a low Li concentration of 0.5 m are demonstrated by employing 3D porous polymer fibers featuring Li+‐affinity on Cu electrodes. Raman and IR spectroscopic analyses exhibit that the polymeric fibers composed of carboxyl and hydroxyl groups can form Li‐binding complexes and decrease interactions with solvents and anions in the electrolyte. The electrochemical analyses support that this polymeric porous structure serves to retain Li+ near the electrode, expanding the active surface area and increasing current density. The Li‐affinitive polymer fibers are effective even at a low Li salt concentration of 0.5 m to improve NH3 yield and Faradaic efficiency. This study underscores the importance of porous morphology, Li affinity, and its analytical methods in understanding Li‐NRR.
Octopus‐Inpired Multicamouflage Smart Fabric by Dynamic‐Bond‐Based Hydrochromic Artificial Muscle
Authors: Leng Xueqi , Liu Lisha , Liu Shiyong , Li Yuanyuan , Xiao Yicheng , Bao Lili , Zhu Meifang , zhou Qiang , Zhu Tianyu , Xue Lihao , Liu Zunfeng , Zhou Xiang 
Published: January 2025

AbstractIn nature, many animals protect themselves through deformation, discoloration, and infrared concealment to achieve multiple forms of camouflage. Camouflage fabrics designed for deserts and rainforests have vastly different requirements for color, breathability, and infrared emission. However, the development of corresponding smart fabrics remains a significant challenge. In this work, a novel dynamic‐bond‐controlled hygro‐responsive hydrochromic wool fiber artificial muscle, inspired by the octopuses, has been developed, which used to construct a smart multi‐camouflage fabric that integrates deformation, allochromasia, and infrared concealment. The obtained fabric exhibits a green color in humid environments (rainforests), with large pores for perspiration. In a dry environment (deserts), the fabric contracts and changes to akhaki color, while the reduction in pore size enhances infrared shielding. As the relative humidity increases from 20% to 100%, the average pore size of multi‐camouflage smart fabric decreases by ∼84%, minimizing the radiative temperature difference between 36 °C target. This results in a temperature reduction of 5.2 °C for the target. The hydrochromic artificial muscle is also employed to develop smart fabrics that mimic octopus‐like behaviors. With its biocompatible, biodegradable, high thermal insulation, and comfortable wearability, the dynamic‐bond‐based multifunctional muscle fabric opens up additional possibilities for smart textiles, information technology, and artificial intelligence.
Multiple Schottky Contacts Motivated via Defects to Tune the Response Ability of Electromagnetic Waves
Authors: Chen Yikun , Wang Xinqiang , Cui Wen‐Gang , Gao Yong , Pan Hongge , Wang Yan , Che Renchao 
Published: January 2025

AbstractMetal‐organic framework (MOF) derivatives employed as novel microwave‐absorbing materials (MAMs) have garnered significant attention due to their diverse in situ or ex situ coordinated components and the flexibility in nano‐microstructure fabrication. A well‐designed heterointerface can provide an optimal balance between impedance and high‐loss capability. However, precisely tuning semiconductor‐metal‐carbon heterostructures remains a huge challenge. Herein, a multi‐component NiS/Co3S4/NiCo@CNTs/NC nanohybrid with hollow structure is elaborately fabricated using a convenient solvothermal method followed by high‐temperature pyrolysis, forming a unique heterostructure with multiple Schottky contacts. This nanohybrid demonstrates a remarkable reflection loss value of −75.9 dB at thickness of 2.6 mm. The transcendent microwave absorption (MA) capacity is primarily attributed to the intense polarization relaxation process and superb impedance‐matching properties of the semiconductor/metal/carbon hybrid structure with Schottky barriers. In addition, the built‐in electric field established at the Schottky heterointerfaces increases the electron transport capabilities. Notably, the controllable introduction of numerous defects into the carbon layer intensifies the interfacial polarization effect at the Schottky heterointerfaces of the nanohybrid. This study offers innovative insights into the mechanisms of polarization loss and the development of high‐performance MAMs.
Structure Engineering by Picosecond Laser Lithography Boosts Highly Reversible Zn Anode
Authors: Zhan Shengkang , Liu Zixuan , Ning Fanghua , Liu Xiaoyu , Dai Ye , Lu Shigang , Xia Yongyao , Yi Jin 
Published: January 2025

AbstractThe practical application of aqueous zinc ion batteries (AZIBs) is impeded by the instability of the Zn anode|electrolyte interface, including dendrite growth, hydrogen evolution reaction (HER), and corrosion. Herein, the periodical micro‐nano structure is constructed on the surface of Zn anode through picosecond laser lithography (PLL) technology. This micro‐nano surface structure is conductive to obtain hydrophobicity for diminishing direct contact between the electrolyte and Zn anode, enhancing the corrosion resistance of the Zn anode. Simultaneously, the low surface energy and reconstructed electric field are achieved through laser‐induced texture microstructure, leading to the oriented Zn2+ deposition along the (002) plane. As a result, the lower electrochemical polarization and long cycling stability of 1400 h for Zn||Zn symmetric cell is achieved at 4 mA cm−2 and 2 mAh cm−2. The average coulombic efficiency (CE) of the Zn||Cu cell is enhanced to 99.83% at 2 mA cm−2, while the Zn||MnO2 cell delivers a capacity retention of 68.7% after 600 cycles at 1 A g−1. Consequently, the advantages of micro‐nano structure can highlight the importance of surface structure design for the development of stable Zn anode.
Active Electron Cooling of Graphene
Authors: Paolucci Federico , Bianco Federica , Giazotto Francesco , Roddaro Stefano 
Published: January 2025

AbstractIn the emergent field of quantum technology, the ability to manage heat at the nanoscale and in cryogenic conditions is crucial for enhancing device performance in terms of noise, coherence, and sensitivity. Here, active cooling and refrigeration of the electron gas in graphene are demonstrated, by taking advantage of nanoscale superconducting tunnel contacts able to pump or extract heat directly from the electrons in the device. These structures achieved a top cooling of electrons in graphene of ∼15.5 mK at a bath temperature of ∼448 mK, demonstrating the viability of the proposed device architecture. These experimental findings are backed by a detailed thermal model that accurately replicated the observed behavior. Alternative cooling schemes and perspectives are discussed in light of the reported results. Finally, graphene electron cooling could find application in superconducting hybrid quantum technologies, such as radiation detectors, logic gates and qubits.
Tandem Active Sites in Cu/Mo‐WO3 Electrocatalysts for Efficient Electrocatalytic Nitrate Reduction to Ammonia
Authors: Dai Ying , Li Shuangjun , Li Xue , Liu Kaihong , Guo Yanna , Li Hexing , Jiang Bo 
Published: January 2025

AbstractElectrocatalytic NO3− reduction to NH3 is a promising technique for both ammonia synthesis and nitrate wastewater treatment. However, this conversion involves tandem processes of H2O dissociation and NO3− hydrogenation, leading to inferior NH3 Faraday efficiency (FE) and yield rate. Herein, a tandem catalyst by anchoring atomically dispersed Cu species on Mo‐doped WO3 (Cu5/Mo0.6‐WO3) for the NO3RR is constructed, which achieves a superior FENH3 of 98.6% and a yield rate of 26.25 mg h−1 mgcat−1 at −0.7 V (vs RHE) in alkaline media, greatly exceeding the performance of Mo0.6‐WO3 and Cu5/WO3 counterparts. Systematic electrochemical measurement results reveal that the promoted activation of NO3− on Cu sites, accompanying accelerated water dissociation producing active hydrogens on Mo sites, are responsible for this superior performance. In situ infrared spectroscopy and theoretical calculation further demonstrate that atomically dispersed Cu sites accelerate the conversion of NO3− to NO2−, and the Mo dopant activates adjacent Cu sites, resulting in the decreased energy barrier of *NO2 to *NO and the stepwise hydrogenation processes, making the synthesis of NH3 thermodynamically favorable. This work demonstrates the critical role of tandem active sites at atomic level in enhancing the electrocatalytic NO3− reduction to NH3, paving a feasible avenue for developing high‐performance electrocatalysts.
Impact of Electrolyte Decomposition on Copper Corrosion in Li6PS5Cl‐Based All‐Solid‐State Batteries
Authors: Kwon Ohmin , Kang Juhui , Kim Suhyeon , Yoon Taeho 
Published: January 2025

AbstractAll‐solid‐state batteries (ASSBs) with sulfide‐based electrolytes, such as argyrodite (Li₆PS₅Cl, LPSCl), offer significant advantages regarding safety and energy density. However, conventional Cu current collectors with LPSCl suffer from corrosion, necessitating a deeper understanding of appropriate mechanisms and strategies to address them. This study investigates the impact of electrolyte decomposition on Cu degradation in sulfide‐based ASSBs. Accelerated experiments reveal that LPSCl decomposition forms an ineffective passive layer on Cu, resulting in significant corrosion above 2 V during delithiation. In addition, the corrosion potential implies that sulfide and chlorine species are involved in the corrosion reaction. Comparative analyses with Ni current collectors, which are known for their resistance to the corrosive species, demonstrate superior stability to Cu. Corrosion‐prevention strategies are proposed based on the elucidated mechanisms, with the Pilling–Bedworth ratio explaining why certain metal sulfide layers formed during electrolyte decomposition may fail to effectively prevent corrosion. These insights support the development of targeted protective strategies and alternative current collector materials to enhance the durability and performance of sulfide‐based ASSBs.
Oxygen Edge‐Sharing Strategy in P2‐Type Na0.67MnO2 Cathodes: Synergistic Enhancement of Intercalation Kinetics and Air Stability
Authors: Liu Yuanming , Wang Shiyu , Fu Weijie , Yao Shuyun , Ji Yingjie , Li Jingxian , Shi Lanlan , Wang Xiaojun , Zhang Feike , Yang Jinghua , Liu Ruilong , Xie Jiangzhou , Yang Zhiyu , Yan Yi‐Ming 
Published: January 2025

AbstractMn‐based layered oxides have garnered significant attention as cathode materials for energy storage due to their environmental benignity and high theoretical specific capacity. However, practical applications remain constrained by sluggish Na+ intercalation kinetics and poor structural stability. In this study, it is engineered that the Mn‐O‐B unit through an oxygen edge‐sharing strategy to modulate Mn─O covalency in P2‐type Na0.67MnO2, thereby achieving high specific capacity and structural stability. Both experimental results and density functional theory (DFT) calculations reveal that increased TM‐O covalency facilitates Na+ diffusion in P2‐type Na0.67MnO2 while simultaneously enhancing air stability. The as‐prepared P2‐type Na0.67MnB0.05O2 exhibits a specific capacitance of 452 F g−1 at 1 A g−1, maintaining 96.75% capacity retention after 8800 cycles. This work elucidates the critical role of oxygen edge‐sharing in optimizing interactions between transition metal and oxygen atoms, establishing a relationship between Mn─O structure and functional properties. These findings advance the development of high‐performance energy storage technologies.
Unique H2O Vortex in One New MOF Material Strengthening C3H6 Adsorption and Unprecedented Purification from C2H4/C3H8/C3H6 Mixtures
Authors: Zhang Lin , Gao Rui‐Cheng , Liu Xin , Zhang Bin , Hou Lei , Wang Yao‐Yu 
Published: January 2025

AbstractThe gradual separation of the naphtha steam cracking product (propane/propylene/ethylene, C3H8/C3H6/C2H4) to obtain highly pure C3H6 is of great significance as it provides an alternative process for this important industrial feedstock. However, developing adsorbents to meet the efficient separation and purification application remains challenging. A water coordination‐decorated metal–organic framework (MOF, Cd‐dtzip‐H2O) material is reported. Interestingly, water molecules cooperate with the framework to build a water vortex and significantly affect the preferential adsorption for C3H6. At 298 K and 100 kPa, the loading of C3H6 in the material is 112.0 cm3 g−1, equivalent to 1.7 and 2.0 times of C3H8 and C2H4, respectively. Experimental breakthroughs show that the material efficiently separates C3H6/C3H8 and C3H6/C2H4 under different pressures. Meanwhile, it also unprecedentedly achieves the one‐step separation of C2H4/C3H8/C3H6 mixtures yielding high‐purity C3H6 (99.9%) and C2H4 (99.95%) products with the productivities of 38.2 and 12.7 L kg−1, respectively.
Plasmonic Nanodiamond – Microneedle Bioinspired System for Ultrarapid Sampling and Quantum Sensing of Melanoma‐Related MiRNA
Authors: Wu Min , Liu Lei , Xing Youqiang , Wu Ze , Huang Peng , Li Bingjue 
Published: January 2025

AbstractMicroRNA (miRNA) in interstitial fluid (ISF) is a promising biomarker for early disease diagnosis, but its quantification is challenging due to low sampling efficiency and weak signals. Here, inspired by the osmotic pressure‐driven feeding mechanism of sea anemones, a novel is designed that plasmonic nanodiamonds – microneedles (PND‐MNs) bioinspired system for ultrarapid sampling and quantum sensing of melanoma‐related miRNA. Specifically, high‐osmotic hydrogel microneedles, prepared by immersing in LiCl solution, exhibit a substantial swelling ratio for rapid ISF enrichment, extracting 0.92 ± 0.14 mg within 5 min. Concurrently, by coating fluorescent nanodiamonds (FNDs) with hollow composite metal Au‐Ag NPs, precise modulation of the fluorescence intensity of nitrogen vacancy color centers (NV‐center) in FNDs has been achieved. This innovative quantum sensing technology significantly enhances the fluorescence signal in the PND‐MNs bioinspired system, amplifying it by a factor of 16, reducing the detection limit of miRNA to an unprecedented 0.68 fm (to the knowledge, no method based on fluorescent microneedles for detecting biomarkers has surpassed this level). Furthermore, the PND‐MNs bioinspired system, employing backpropagation neural network (BPNN), achieves high accuracy in recognizing miRNA concentrations (R2 = 0.9986). By combining rapid sampling, signal enhancement, and machine learning, it holds promise for detecting ISF biomarkers, offering significant clinical applications.
Enhancement of Osseointegration via Endogenous Electric Field by Regulating the Charge Microenvironments around Implants
Authors: Xu Fangfang , Zhao Guangbin , Gong Yuxin , Liang Xiang , Yu Ming , Cui Hao , Xie Linyang , Zhu Nan , Zhu Xuan , Shao Xiaoxi , Qi Kun , Lu Bingheng , Tu Junbo , Na Sijia 
Published: January 2025

AbstractThe regulation of the charged microenvironment around implants is an effective way to promote osseointegration. Although homeostasis of the charged microenvironment plays an integral role in tissues, current research is externally invasive and unsuitable for clinical applications. In this study, functional materials with different surface potential differences are prepared by changing the spatial layout of Ta and Ag on the surface of a Ti‐6Al‐4V alloy (TC4). This naturally formed an endogenous electric field (EEF) with a negatively charged cell membrane after in vivo implantation and promoted osseointegration at the interface between the bone and implant through the upregulation of Ca2+ concentration and activation of subsequent pathways. Interestingly, the promotion of stem cell differentiation, regulation of the direction of immune cell polarization, and antibacterial efficacy are determined by the free charge contained in the implant, rather than by the magnitude of the surface potential difference. This functional implant represents a unique strategy for regulating the charged microenvironment around the implant and enhancing osseointegration, thereby providing ideas and technical approaches for the clinical development of novel implant materials.
Multifunctional Carbon Dots In Situ Confined Hydrogel for Optical Communication, Drug Delivery, pH Sensing, Nanozymatic Activity, and UV Shielding Applications
Authors: Marvi Parham Khoshbakht , Das Poushali , Jafari Arman , Hassan Shiza , Savoji Houman , Srinivasan Seshasai , Rajabzadeh Amin Reza 
Published: January 2025

AbstractInspired by the emerging potential of photoluminescent hydrogels, this work unlocks new avenues for advanced biosensing, bioimaging, and drug delivery applications. Carbon quantum dots (CDs) are deemed particularly promising among various optical dyes, for enhancing polymeric networks with superior physical and chemical properties. This study presents the synthesis of CDs derived from Prunella vulgaris, a natural plant resource, through a single‐step hydrothermal process, followed by their uniform integration into hydrogel matrices via an in situ free radical graft polymerization. The resulting CD‐integrated hydrogels exhibit multifunctionality in biomedical applications, featuring a diffusion‐controlled drug release mechanism, permit concurrent delivery of photoluminescent CDs and therapeutic agents, enabling real‐time monitoring over 32 h. In addition, these hydrogels function as a broad‐range optical pH sensor (pH 3–11), provide robust ultraviolet (UV) shielding, and demonstrate nanozyme‐like peroxidase activity. Critically, biocompatibility tests confirm their non‐cytotoxicity toward fibroblast cells, establishing these hydrogels as promising candidates for diverse biomedical applications. These include advanced wound dressings that monitor the healing process and detect infection through pH sensing, and promote healing through the nanozymatic activity, all while maintaining a moist wound microenvironment. These hydrogels demonstrate exceptional suitability for advanced smart drug delivery, effective UV‐blocking, and as innovative platforms for in vivo sensing and bioimaging.
Polycationic γ‐Cyclodextrin with Amino Side Chains for a Highly Efficient Anti‐Heparin Coagulant
Authors: An Wen‐Jin , Lei Zhuo , Yu Xiao‐Yong , Liu Chu‐Han , Zhang Chen , Chen Yong , Liu Yu 
Published: January 2025

AbstractMulticharged cyclodextrins have attracted significant attention because of their applications in biology and pharmaceuticals. This study reports an aminoethoxy‐phenyl‐pyridinium‐modified γ‐cyclodextrin (PyA‐γ‐CD) as a highly efficient coagulant for heparin through multivalent interactions. The UV titration experiment is performed to obtain apparent binding constants (Kobs) between PyA‐γ‐CD and heparin as high as 9.85 × 106 M−1. The activated partial thromboplastin time (aPTT) experiment in porcine plasma indicates that PyA‐γ‐CD not only exhibits nearly complete neutralization activity for unfractionated heparin (UFH), but more importantly, it also effectively neutralizes three LMWHs (dalteparin (Dalte), enoxaparin (Enoxa), and nadroparin (Nadro)) with a broader therapeutic window compared to protamine. The top neutralization activity of PyA‐γ‐CD for UFH, Dalte, Enoxa, and Nadro is 94%, 91%, 99%, and 85%, respectively. Interestingly, in vivo assays in mice further suggest that PyA‐γ‐CD significantly reverses the severe bleeding caused by heparin overdose while exhibiting remarkable biocompatibility. Therefore, PyA‐γ‐CD holds significant potential as a heparin antidote for clinical applications.