bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclic Mechanical Stresses Alter Erythrocyte Membrane Composition and Microstructure and Trigger Macrophage Phagocytosis
Authors: Garcia‐Herreros Antoni , Yeh Yi‐Ting , Peng Zhangli , del Álamo Juan C. 
Published: May 2022

AbstractRed blood cells (RBCs) are cleared from the circulation when they become damaged or display aging signals targeted by macrophages. This process occurs mainly in the spleen, where blood flows through submicrometric constrictions called inter‐endothelial slits (IES), subjecting RBCs to large‐amplitude deformations. In this work, RBCs are circulated through microfluidic devices containing microchannels that replicate the IES. The cyclic mechanical stresses experienced by the cells affect their biophysical properties and molecular composition, accelerating cell aging. Specifically, RBCs quickly transition to a more spherical, less deformable phenotype that hinders microchannel passage, causing hemolysis. This transition is associated with the release of membrane vesicles, which self‐extinguishes as the spacing between membrane‐cytoskeleton linkers becomes tighter. Proteomics analysis of the mechanically aged RBCs reveals significant losses of essential proteins involved in antioxidant protection, gas transport, and cell metabolism. Finally, it is shown that these changes make mechanically aged RBCs more susceptible to macrophage phagocytosis. These results provide a comprehensive model explaining how physical stress induces RBC clearance in the spleen. The data also suggest new biomarkers of early "hemodamage" and inflammation preceding hemolysis in RBCs subjected to mechanical stress.
Insights from a decade in the life of public Ph.D.‐granting agricultural economics departments
Authors: Hilmer Christiana E. , Hilmer Michael J. 
Published: May 2022

AbstractWe examine annual salaries over a 10‐year period for 423 teaching/research faculty in 23 public Ph.D.‐granting agricultural economics departments. To our knowledge, this is the first study to analyze panel data for agricultural economics faculty members from a variety of universities. Using a fixed effects model, we find that the highest returns are derived from gaining years of experience, moving between universities, receiving tenure, and obtaining the rank of full professor. The fixed effects estimation relative to a cross‐section does not show evidence of the negative returns to seniority that is typically found in studies analyzing academic labor markets.
TEMPO‐Oxidized Nanofibrillated Cellulose Assisted Exfoliation of MoS2/Graphene Composites for Flexible Paper‐Anodes
Authors: Cao Shaomei , Liu Panpan , Miao Miao , Fang Jianhui , Feng Xin 
Published: May 2022

AbstractTEMPO‐oxidized nanofibrillated cellulose (ONFC) with charged carboxyl groups is introduced for the efficient exfoliation of two‐dimensional (2D) MoS2/graphene composites. As an effective dispersant agent, ONFC can be easily absorbed between the adjacent layers, so as to prevent the accumulation of the exfoliated nanosheets. With the assistance of charged ONFC, the exfoliated MoS2/graphene is gradually increased in the aqueous dispersions with the elongated sonication time. After dewatering, self‐standing MoS2/Graphene/ONFC/CNTs composite films are rationally constructed using ONFC as flexible fibrous skeleton, and CNTs/graphene as 1D/2D interpenetrating electrical networks. Ultrathin MoS2 nanosheets anchored on the 1D/2D heterogeneous networks is directly acted as an ideal paper‐anode for lithium‐ion batteries (LIBs) without using traditional metallic current collector. The self‐standing flexible electrode materials based on natural cellulose will promote the future green electronics with high flexibility, miniaturization, and increased portability.
High‐level production of wild‐type and oxidation‐resistant recombinant alpha‐1‐antitrypsin in glycoengineered CHO cells
Authors: Koyuturk Izel , Kedia Surbhi , Robotham Anna , Star Alexandra , Brochu Denis , Sauvageau Janelle , Kelly John , Gilbert Michel , Durocher Yves 
Published: May 2022

AbstractAlpha‐1‐antitrypsin (A1AT) is a serine protease inhibitor which blocks the activity of serum proteases including neutrophil elastase to protect the lungs. Its deficiency is known to increase the risk of pulmonary emphysema as well as chronic obstructive pulmonary disease. Currently, the only treatment for patients with A1AT deficiency is weekly injection of plasma‐purified A1AT. There is still today no commercial source of therapeutic recombinant A1AT, likely due to significant differences in expression host‐specific glycosylation profile and/or high costs associated with the huge therapeutic dose needed. Accordingly, we aimed to produce high levels of recombinant wild‐type A1AT, as well as a mutated protein (mutein) version for increased oxidation resistance, with N‐glycans analogous to human plasma‐derived A1AT. To achieve this, we disrupted two endogenous glycosyltransferase genes controlling core α−1,6‐fucosylation (Fut8) and α−2,3‐sialylation (ST3Gal4) in CHO cells using CRISPR/Cas9 technology, followed by overexpression of human α−2,6‐sialyltransferase (ST6Gal1) using a cumate‐inducible expression system. Volumetric A1AT productivity obtained from stable CHO pools was 2.5‐ to 6.5‐fold higher with the cumate‐inducible CR5 promoter compared to five strong constitutive promoters. Using the CR5 promoter, glycoengineered stable CHO pools were able to produce over 2.1 and 2.8 g/L of wild‐type and mutein forms of A1AT, respectively, with N‐glycans analogous to the plasma‐derived clinical product Prolastin‐C. Supplementation of N‐acetylmannosamine to the cell culture media during production increased the overall sialylation of A1AT as well as the proportion of bi‐antennary and disialylated A2G2S2 N‐glycans. These purified recombinant A1AT proteins showed in vitro inhibitory activity equivalent to Prolastin‐C and substitution of methionine residues 351 and 358 with valines rendered A1AT significantly more resistant to oxidation. The recombinant A1AT mutein bearing an improved oxidation resistance described in this study could represent a viable biobetter drug, offering a safe and more stable alternative for augmentation therapy.
Atypical Parkinsonism: Methamphetamine may play a role
Authors: Salari Mehri , Hojjati Pour Fatemeh , Rashedi Ronak , Etemadifar Masoud 
Published: May 2022

AbstractAbusing methamphetamine can be considered as an agent that can cause or affect the course of atypical parkinsonian syndromes (APS), which may raise attention regarding preventing abusing these drugs.
Patient with Dravet syndrome: A case report
Authors: Yadav Rukesh , Shah Sangam , Bhandari Bibek , Marasini Kundan , Mandal Prince , Murarka Hritik , Pandey Anuj Kumar , Sharma Paudel Basanta 
Published: May 2022

AbstractDravet syndrome is rare genetic epilepsy syndrome and epileptic encephalopathy. The patient initially has normal developmental profile with plateau or regression that begins after seizure onset. We report a case of two‐year‐old child diagnosed as dravet syndrome with moderate cerebral atrophy and ventricular dilatation as rare MRI finding.
Investigation and Visualization of Flow Fields in Stirred Tank Reactors Using a Fluorescence Tracer Method
Authors: Matzke Marian , Behrens Cheryl , Jongebloed Niklas , Steins Dominik , Ulbricht Mathias , Schultz Heyko Jürgen 
Published: May 2022

AbstractIn this study, flow fields in stirred tank reactors are investigated by a fluorescence tracer method. For these measurements, a fluorescent dye is inserted into a stirred tank reactor and distributed by the impeller flow, following the characteristic main circulation pathways. By this means, the main flow fields can be detected and visualized. Originally developed and used for the investigation of viscoelastic fluids, the method was adapted for Newtonian fluids with low viscosity in this study, with impeller installation height and impeller Reynolds numbers selected as influencing parameters. The resulting flow fields in both single‐ and double‐impeller setups match the known structures from literature excellently. Therefore, the developed fluorescence tracer method has proven to be a promising supplement to the established repertoire of fluid investigation methods, with little effort in both experiment itself as well as the following data analysis steps.
Ein Radarsensor für alle Medien
Authors: Gandert Etwina 
Published: May 2022

AbstractVia Webapplikation den Radarsensor im Beschaffungsprozess selbst konfigurieren und sich dabei keine Gedanken über das richtige Modell für die geplante Anwendung machen. Das klingt schon sehr simpel, aber genau das ist die Idee hinter dem neuen Konzept des Füllstandssensors Vegapuls 6x von Vega. Der Messtechnikhersteller setzt in dem Sensor eine neue Chiptechnologie ein, die sich nicht nur für Schüttgüter oder Flüssigkeiten programmieren lässt, sondern die auch SIL‐fähig und gegen Cyberangriffe gewappnet ist.
Hochwirksame Konzentrate sicher herstellen
Authors: Hilleke Ludger 
Published: May 2022

AbstractUm Pflanzenschutzmittel herzustellen, sind moderne Prozessanlagen notwendig. Im Fachbeitrag werden die Prozessschritte Vakuumtrocknen und Mischen‐Kühlen im Detail betrachtet: Wie lässt sich apparatetechnisch thermischer Stress am besten vermeiden? Welche Rolle spielen Mischgüten und Wärmetauschflächen? Weshalb können Amixon‐Apparate aufgrund ihrer besonderen Konstruktionsmerkmale in diesem herausfordernden Umfeld zur Produktionseffizienz beitragen?
Die Qualität im Blick behalten
Authors: Gehard Iris 
Published: May 2022

AbstractDa der Leitstand im Werk von Heidelberg Cement in Ennigerloh in die Jahre gekommen war, entschieden sich die Verantwortlichen für eine komplette Neugestaltung der Anlagenüberwachung. In den von der Jungmann Systemtechnik (JST) eingerichteten Räumlichkeiten befindet sich nun ein hochmoderner Kontrollraum mit zwei ergonomischen Arbeitsplätzen für die Operator und flexibel einsetzbarer Technik.
Development of Isatin‐Based Schiff Bases Targeting VEGFR‐2 Inhibition: Synthesis, Characterization, Antiproliferative Properties, and QSAR Studies
Authors: Seliem Israa A. , Panda Siva S. , Girgis Adel S. , Tran Queen L. , Said Mona F. , Bekheit Mohamed S. , Abdelnaser Anwar , Nasr Soad , Fayad Walid , Soliman Ahmed A. F. , Sakhuja Rajeev , Ibrahim Tarek S. , Abdel‐Samii Zakaria K. M. , Al‐Mahmoudy Amany M. M. 
Published: May 2022

AbstractThree sets of isatin‐based Schiff bases were synthesized utilizing the molecular hybridization approach. Some of the synthesized Schiff bases show significant to moderate antiproliferative properties against MCF7 (breast), HCT116 (colon), and PaCa2 (pancreatic) cancer cell lines with potency compared to reference drugs 5‐fluorouracil (5‐FU) and Sunitinib. Among all, compound 17 f (3‐((1,5‐dimethyl‐3‐oxo‐2‐phenyl‐2,3‐dihydro‐1H‐pyrazol‐4‐yl)imino)‐1‐((1‐(2‐methoxyphenyl)‐1H‐1,2,3‐triazol‐4‐yl)methyl)‐5‐methylindolin‐2‐one) exhibits promising antiproliferative properties against the MCF7 cancer cell line with 2.1‐fold more potency than Sunitinib. However, among all the synthesized compounds, three (5‐methylisatin derivatives) were the most effective against HCT116 in comparison to 5‐FU. Compound 17 f exhibited the highest anti‐angiogenic effect on the vasculature as it significantly reduced BV from 43 mm to 2 mm in comparison to 5.7 mm for Sunitinib and flow cytometry supports the arrest of the cell cycle at G1/S phases. In addition, compound 17 f also showed high VEGFR‐2 inhibition properties against breast cancer cell lines. Robust 2D‐QSAR studies supported the biological data.
Psychological predictors of treatment adherence among patients with diabetes (types I and II): Modified information–motivation–behavioural skills model
Authors: Akbari Mehdi , Seydavi Mohammad , Rowhani Nayyereh S. , Nouri Naemeh 
Published: May 2022

AbstractNon‐adherence to medical regimens among patients with diabetes is a well‐recognized concern in health care. Modified information, motivation, behavioural skills (IMB) model by adding an emotion component to it was tested to explore predictors of treatment adherence among 1,125 Iranian patients with diabetes type I (T1D) and type II (T2D) and due to other medical conditions. The modified IMB model explained 35% of the treatment adherence with large effect‐sizes f2 = 0.56 to 0.69. Self‐compassion and interpersonal communication between staff and patients (ICSP) were significant predictors of treatment adherence among patients with T1D, T2D and diabetes due to other medical conditions, while both outperformed the other significant predictors of treatment adherence, i.e., illness perception and social support in all groups. Distress intolerance was a significant predictor of treatment adherence only in patients with T2D. In addition, patients, based on their type of diabetes, exhibited different patterns of illness perception in predicting treatment adherence. Among T2D patients and those with diabetes due to other medical conditions, gender (male; only in T2D) and being single were significant predictors of treatment adherence, while age and diabetes duration were not. Finally, the model demonstrated that above and beyond demographic features, self‐compassion, interpersonal communication between patients and health care staff, distress intolerance, perceived social support and illness perception were significant predictors of treatment adherence among patients with diabetes.
Evaluation of fluoride varnish treatment of postorthodontic white spot lesions by visual inspection and laser fluorescence—A randomized controlled study
Authors: Tomaževič Tanja , Drevenšek Martina , Kosem Rok 
Published: May 2022

AbstractObjectivesWhite spot lesions (WSLs), as a side effect of orthodontic therapy, can be treated with fluoride varnish, with the difference in efficiency reported.Material and methodsPatients with buccal WSLs were consecutively included in a randomized controlled double‐blind study. At first inspection and at three follow‐ups over 6 months, 0.1% fluoride varnish and placebo (water) were applied in the test group (N = 21) and control group (N = 21), respectively. The maximum laser fluorescence value (LFV) of WSLs was recorded using DIAGNOdent. Between the groups, differences in the mean numbers of WSLs and the mean LFV of WSLs per patient at different time points were analyzed with mixed‐design analysis of variance. Orthodontic therapy duration (OTD) was included in the model as a covariate.ResultsA decrease in the mean WSLs number and LFV was observed; however, there were no significant differences between study groups at any time point. OTD was in interaction only with LFV. Analysis showed a different pattern of mean LFV changes for patients with OTD of >48 months compared to patients with OTD of ≤24.ConclusionThe changes in numbers of WSLs and LFV over the study period indicated regression of WSLs, but an additional effect of FV was not confirmed.
Unheard voices: The impact of the COVID‐19 pandemic on disordered eating in people with marginalized identities: Commentary on Devoe et al. (2022), Linardon et al. (2022) and Schneider et al. (2022)
Authors: Mikhail Megan Elizabeth 
Published: May 2022

AbstractReviews by Devoe et al. (2022), Linardon et al. (2022), and Schneider et al. (2022) illustrate the profound impact the COVID‐19 pandemic has had on people with eating disorders (EDs) or disordered eating (DE) and their families. However, there is a dearth of research on how the pandemic has affected individuals with marginalized identities, who have been historically underrepresented in ED/DE research. The few studies conducted to date suggest that people with marginalized identities, including people of color, LGBTQ + people, women, and people experiencing socioeconomic disadvantage, may have had even greater increases in EDs/DE than people without marginalized identities. In this Commentary, I discuss who is missing from research on EDs/DE during the COVID‐19 pandemic, strategies for breaking down barriers to participation in research for diverse groups, and the implications of existing research findings for people with marginalized identities. Improved measurement of salient aspects of participants' identities and increased recruitment and retention of participants from diverse backgrounds is necessary to more fully understand the impact of the COVID‐19 pandemic on all people affected by EDs and DE. Concurrently, increased access to affordable and culturally sensitive care is urgently required to meet the extensive treatment needs already documented
Reply to comment on “How Green is Blue Hydrogen?”
Authors: Howarth Robert W. , Jacobson Mark Z. 
Published: May 2022

AbstractIn their comment on our 2021 paper “How Green is Blue Hydrogen,” Romano et al. purport to provide “a more balanced perspective on blue hydrogen, which is in line with current best available practices.” We strongly disagree. First, we categorically dismiss their presentation on methane emissions. Methane dominates the greenhouse gas footprint of blue hydrogen in our analysis, and our estimates were based on very recent, peer‐reviewed science. Romano et al., in sharp contrast, use only three sources: (1) a 2015 non‐peer‐reviewed report (which gave reasonable values, although at the low end, since based on older science, but nonetheless compatible with our paper); (2) a 2018 report from the International Energy Agency (which also gave values consistent with ours, but has been updated by the Agency in a 2022 report to give much higher values that are very consistent with ours); and (3) a value from a cartoon on a web site from an oil and gas industry trade group (i.e., not supported by any data or references and is simply wrong based on peer‐reviewed science). We cannot stress enough that the Romano et al. criticism of our methane emission rates is based totally on this industry web‐site cartoon. Beyond the methane issue, our analysis used actual data for capture of carbon dioxide from real‐world operations. Romano et al. dismiss the use of real‐world data, and instead rely on presentations from theoretical studies. We find this fanciful. But even if one accepts their theoretical values for carbon capture, the greenhouse gas footprint of blue hydrogen remains unacceptably high because of methane. We unequivocally stand by our analyses and conclusions: There is no room for blue hydrogen in a decarbonized energy future. The Romano et al. result derives from a cartoon and hypothetical guesses, not scientific data.
Exploring changes to resident thriving and associated factors in Swedish nursing homes: A repeated cross‐sectional study
Authors: Baxter Rebecca , Lövheim Hugo , Björk Sabine , Sköldunger Anders , Edvardsson David 
Published: May 2022

AbstractObjectiveThis study aimed to explore changes to resident thriving in Swedish nursing homes over a 5‐year period and describe changes in associated factors.MethodsCross‐sectional data were collected from a randomised sample of Swedish nursing homes in 2013/2014 (baseline) and 2018/2019 (follow‐up). Descriptive statistics, independent samples t‐tests, and chi squared tests were used to statistically evaluate differences between the samples. Simple and multiple linear regression analyses were used to explore associations between thriving and the study variables.ResultsResident characteristics were relatively consistent between the full baseline (N = 4831) and follow‐up (N = 3894) samples. Within a sub‐sample of nursing homes that participated in both data collections mean thriving scores were found to have increased from 152.9 to 155.2 (p ≤ 0.003; d =0.09) and overall neuropsychiatric index scores had decreased from 16.0 to 14.3 (p ≤ 0.004; d =0.09), as had the prevalence of several neuropsychiatric symptoms. Thriving was found to have a positive association with the neuropsychiatric symptom of elation/euphoria, and negative associations with the symptoms of aggression/agitation, depression/dysphoria, apathy, and irritability.ConclusionsThe results show an increase in overall thriving scores and a decrease in overall neuropsychiatric scores between baseline and follow‐up. This study confirmed associations between thriving and certain neuropsychiatric symptoms and established comparative knowledge regarding changes in resident thriving, characteristics, and symptom prevalence. These findings could inform future care and organisational policies to support thriving in nursing homes, particularly among residents at risk of lower thriving due to cognitive impairment or neuropsychiatric symptoms.
Roots and progress: A review of civic learning and democratic engagement on college campuses
Authors: Taylor Joshua K. , Rouillard Jansen 
Published: May 2022

AbstractIn this chapter, the authors trace the historical roots of civic learning and democratic engagement in higher education from the founding of the first institutions to the present day. In different major historical moments, universities elevated their mission to develop an engaged citizenry. Furthermore, public perception of the purpose for higher education acts as a pendulum, swinging between higher education as a public good or as a private good. The intersections of these perceptions, along with critical moments in which colleges and universities emphasized civic learning and democratic engagement shaped the past, and understanding these historical moments can help shape the future ways in which higher education institutions embrace their democratic purpose.
Teaching democracy: The role of public institutions in promoting civic learning
Authors: Lee Jacquelyn J. , McCunney Dennis 
Published: May 2022

AbstractDemocracy requires an informed populous that is engaged, politically, and otherwise, and concerned for the safety and wellbeing of its communities. Public institutions of higher education play a pivotal role in democracy, and a direct pathway to this result is civic learning and democratic engagement (CLDE). Now more than ever, a sharper focus on the ways in which equity and inclusion – dimensions of civic courage – intersect with education for democracy is of paramount importance. To underscore the role of public institutions in promoting civic learning, this chapter explores the historic roots of education for democracy, student affairs and co‐curricular approaches to CLDE, and the role of professional organizations in encouraging CLDE. Challenges and opportunities related to increasing institutional attention to civic learning are discussed.
Reimagining identity development: Inspiring & empowering active civic leaders
Authors: Kermiet Tara N. , Locke Katy V. 
Published: May 2022

AbstractThe vision of what Civic Learning and Democratic Engagement (CLDE) work encompasses within higher education has evolved from voter engagement efforts to broader approaches, which instill a sense of personal identity related to civic leadership. This chapter sheds light on the culture shift of CLDE work at one institution and the ways in which student leadership competencies inspire and empower civic identity through various programs, initiatives, and structures. Using this as a strategy to foster identity development will support students as they establish their capacities as active civic leaders and contribute to a thriving democracy. Our hope is to inspire colleges and universities to embed the student leadership competencies into programs, initiatives, and institutional structures, fostering the identity development of active civic leaders who contribute to a thriving democracy.