bluuebunny/crossref_metadata_2025_split huggingface dataset:
The proliferative and multipotent epidermal progenitor cells for human skin reconstruction in vitro and in vivo
Authors: Lim Jung Hwa , Kim Dae Hun , Noh Kyung Hee , Jung Cho‐Rok , Kang Hyun Mi 
Published: June 2022

AbstractObjectivesThe skin exhibits tremendous regenerative potential, as different types of progenitor and stem cells regulate skin homeostasis and damage. However, in vitro primary keratinocytes present with several drawbacks, such as high donor variability, short lifespan, and limited donor tissue availability. Therefore, more stable primary keratinocytes are needed to generate multiple uniform in vitro and in vivo skin models.ResultsWe identified epidermal progenitor cells from primary keratinocytes using Integrin beta 1 (ITGB1) an epidermal stem cell marker markedly decreased after senescence in vitro. Epidermal progenitor cells exhibited unlimited proliferation and the potential for multipotent differentiation capacity. Moreover, they could completely differentiate to form an organotypic skin model including conversed mesenchymal cells in the dermis and could mimic the morphologic and biochemical processes of human epidermis. We also discovered that proliferation and the multipotent differentiation capacity of these cells relied on ITGB1 expression. Eventually, we examined the in vitro and in vivo wound healing capacity of these epidermal progenitor cells.ConclusionsOverall, the findings suggest that these stable and reproducible cells can differentiate into multiple lineages, including human skin models. They are a potentially powerful tool for studying skin regeneration, skin diseases, and are an alternative for in vivo experiments.
The enablers of entrepreneurship in the tourism sector of Saudi Arabia: An interpretative structured modeling approach
Authors: Alnemer Hashem A. 
Published: June 2022

AbstractThis study aims to model the set of enablers that promote entrepreneurship in the tourism sector of Saudi Arabia using interpretative structural modeling (ISM), a qualitative expert opinion‐based method that helps describe the interrelationship among variables. A review of the literature identified seven major enablers. Drivers and dependence power from the ISM model reveal that collaboration and relaxing visa norms are the primary enablers of entrepreneurship in the tourism sectors of Saudi Arabia, followed by cutting taxes, public–private partnership, and ease of getting tourism business licenses on the second level of the ISM model. Furthermore, the ISM digraph shows that start‐up in the tourism business and entrepreneurship education is highly dependent on the other enablers. To encourage entrepreneurship in the Saudi tourism sector, the government should promote and focus on primary‐ and secondary‐level enablers. This study provides an in‐depth insight into the enablers of entrepreneurship in the tourism sectors of Saudi Arabia, which can help in developing a proper policy framework.
Colors and Orientalism as associations: Exploring the semiotic (re)presentation of Saudi women in British and Saudi newspapers
Authors: Elyas Tariq , Aljabri Abdulrahman , Al‐Harbi Nesreen , A‐Jahani Areej 
Published: June 2022

AbstractMedia representations can have significant influence in shaping opinions and influence public response to certain communities or gender and ethnic representations around the world. Investigating semiotic representation in linguistic discourse as vehicles for meaning in culture has been a fruitful area of research over the past decades. This study explores how stereotypes of women feed into the representations of Saudi women in contemporary press in Britain and Saudi Arabia. The focus is on the newspaper genre. Data for this study have been gleaned from a particular set of British and Saudi newspapers. Using the Color Image Scale (CIS) as a research tool, this study yielded a number of findings, the main one of which is the discrepancy in Saudi women's representation in the journalistic discourse under study. In addition, variances in color choice and usage between the newspapers in the present study were apparent. The study provides an important opportunity to advance our understanding of Saudi women's representation in British versus Saudi newspapers. The present study also makes a major contribution to research on critical discourse analysis by demonstrating how power as well as orientalism impact Saudi women's representation. The findings of this study are important for scholars of gender, religion, media, and cultural diversity.
Prognostic implication of lipidomics in patients with coronary total occlusion undergoing PCI
Authors: Zhou You , Chen Jinxiang , Li Su , Chen Ao , Dai Chunfeng , Liu Muyin , Lu Danbo , Chen Zhangwei , Wang Xiangdong , Qian Juying , Ge Junbo 
Published: June 2022

AbstractBackgroundPredictors of prognosis in patients with coronary chronic total occlusion (CTO) undergoing elective percutaneous coronary intervention (PCI) have remained lacking. Lipidomic profiling enables researchers to associate lipid species with disease progression and may improve the prediction of cardiovascular events.MethodsIn the present study, 781 lipids were measured by targeted lipidomic profiling in 350 individuals (50 healthy controls, 50 patients with coronary artery disease and 250 patients with CTO). L1‐regularized logistic regression was used to identify lipid species associated with adverse cardiovascular events and create predicting models, which were verified by 10‐fold cross‐validation (200 repeats). Comparisons were made between a traditional model constructed with clinical characteristics alone and a combined model built with both lipidomic data and traditional factors.ResultsTwenty‐four lipid species were dysregulated exclusively in patients with CTO, most of which belonged to sphingomyelin (SM) and triacylglycerol (TAG). Compared with traditional risk factors, new model combining lipids and traditional factors had significantly improved performance in predicting adverse cardiovascular events in CTO patients after PCI (area under the curve, 0.870 vs. 0.726, p < .05; Akaike information criterion, 129 versus 156; net reclassification improvement, 0.312, p < .001; integrated discrimination improvement, 0.244, p < .001). Nomogram was built based on the incorporated model and proved efficient by Kaplan–Meier method.ConclusionsLipidomic profiling revealed lipid species which may participate in the formation of CTO and could contribute to the risk stratification in CTO patients undergoing PCI.
Impact of research and development (R&D) and information, and communication technology (ICT) on innovation and productivity evidence from Tunisian manufacturing firms
Authors: Ben Khalifa Adel 
Published: June 2022

AbstractThis study aims to examine the ability of Tunisian manufacturing firms to invest in innovation activities and to transform these investments on innovation outputs and if these outputs have contributed to productivity improvements. It explores the relationship between research and development (R&D), information, and communication technology (ICT) use, product and process innovations and productivity. The study presents an application of the augmented Crépon‐Duguet‐Mairesse (CDM) model for 238 manufacturing firms in Tunisia. Results show that R&D is an important predictor for product innovation, but not for process innovation. The use of ICT has a positive impact on both innovation types, but this impact is more important for the case of process innovation. Furthermore, the study shows the possible existence of a complementary relationship between R&D and ICT. The firms that combine R&D with ICT use increase their probability to introduce product and process innovation. R&D and ICT are also an important indirect driver of firm productivity through innovation activities. Thus, the results show a positive impact of product innovation on firm‐level productivity. However, process innovation has a significant impact only if it is combined with product innovation. The study also identifies guidelines for development actors to better transform ICT and R&D into innovation and productivity in Tunisian economy.
Hexanal combined with decanal mediate host location by the bamboo powderpost beetle, Dinoderus minutus
Authors: Rainho Hugo L. , Silva Weliton D. , Gonçalves Felipe G. , Savaris Marcoandre , Bento José Maurício S. 
Published: June 2022

AbstractThe bamboo powderpost beetle, Dinoderus minutus (Fabricius) (Coleoptera: Bostrichidae), is the major post‐harvest pest of several bamboo species worldwide. Conspecific adults colonize injured bamboo stems, primarily those with low moisture content. Here, the volatiles from dry cut stems of Bambusa vulgaris Schrad. ex J.C. Wendl (Poaceae) were identified and field‐tested for attraction of adults of D. minutus. Analyses of headspace volatile extracts from these stems revealed 22 compounds, of which hexanal was the most abundant, followed by heptanal, octanal, nonanal, decanal, and 2‐pentylfuran. Together, these six compounds comprised >94% of the total abundance of airborne volatiles from dry cut bamboo stems. The biological activity of these compounds was tested in three consecutive field‐trapping trials in Brazil. Broadly speaking, the binary blend of hexanal and decanal was the optimal attractant for both male and female D. minutus adults, whereas hexanal alone was not attractive and the presence of heptanal, octanal, nonanal, and 2‐pentylfuran in some tested blends proved to be redundant or disruptive in attracting conspecific beetles. Traps baited with hexanal and decanal could be used for surveillance and monitoring of D. minutus at countries' points‐of‐entry and for integrated pest management (IPM) at storage facilities of post‐harvest bamboo stems and related products.
The combined foraging of a parasitoid and a predatory bug enhances mortality of Plutella xylostella larvae
Authors: Lankin‐Vega Gabriela , San‐Blas Ernesto , Hogendoorn Katja , Keller Michael 
Published: June 2022

AbstractInteractions between biocontrol agents of crop pests can lead to neutral, detrimental, or improved outcomes for pest control. We investigated the existence and the nature of the additive interactions between a parasitoid, Diadegma semiclausum (Hellén) (Hymenoptera: Ichneumonidae), and two hemipteran predators, Oechalia schellenbergii Guérin‐Méneville (Pentatomidae) and Nabis kinbergii Reuter (Nabidae), of the diamondback moth (DBM), Plutella xylostella (L.) (Lepidoptera: Plutellidae), under laboratory conditions. In the presence of the parasitoid, both O. schellenbergii and N. kinbergii increased predation by 56 and 66%, respectively. The escape response of the prey to avoid being parasitized (moving backwards and sometimes spinning down from the leaf on a silk thread, becoming less cryptic to the predators), may be at the basis of the enhanced predation by these predatory bugs; however, further studies are necessary to test this hypothesis. As the predators did not preferentially consume either parasitised or unparasitised larvae, coincidental intraguild predation should not affect this positive outcome in relation to DBM suppression. The findings highlight the potential utility of combining these natural enemies and may have important implications for the management of DBM in brassica crops in Australia and other multi‐species systems.
Prioritisation tool for targeting the monitoring of veterinary pharmaceuticals in soils at a national level: The case of Spain
Authors: Rodríguez Antonio , Iglesias Irene , de la Torre Ana 
Published: June 2022

AbstractAntibiotics used in animal production are a major source of environmental contamination since most of them are excreted in manure. However, studies on the impact of antimicrobial effects have focused on humans and livestock, neglecting the environment. The European Union (EU) adopted a strategy to prioritise environmental monitoring and develop tools to make it cost‐effective. Our aim was to build a prioritisation tool at a national level to identify hotspot locations for highly occurring antibiotics in soils. Spain was selected as an example, due to its importance for biodiversity, agriculture, antibiotic use and livestock populations in the EU. We built soil vulnerability maps including information about antibiotic use, livestock census, rearing type (intensively reared or pasture animals), and scenario (crop land or pasture). This allowed the identification of sampling sites and antibiotic classes that may require more attention during the early stages of monitoring. The most vulnerable areas were located in the northeast of Spain (crop lands) and in a lesser extent in the west (pasture). A small proportion was located in “High Value Nature” farmlands, highlighting the need for prioritising sampling efforts in those areas because of their importance for biodiversity and ecosystem services. As major antibiotics, tetracyclines and beta‐lactams contributed more to soil vulnerability than less commonly used antibiotics. Intensively reared pigs led to higher vulnerability than the other livestock types. We developed a Shiny dashboard to visualise our results in detail and an R script to execute the model for any antibiotic and country for which data on antibiotic use, livestock census, and raising type are available.Highlights
How to orientate monitoring efforts of antibiotics in soils at early stages according to the PiE?
A prototype is offered here tool to prioritize sampling sites and antibiotics for soil monitoring.
Antibiotic consumption at intensively reared livestock in crop lands were the main contributors.
Intensively reared animals and antibiotic use were the main contributions to soil vulnerability.
This tool allows to execute the model on any antibiotic and EU country for which data is available.
Association of diabetes mellitus and admission glucose levels with outcome after endovascular therapy in acute ischaemic stroke in anterior circulation
Authors: Genceviciute Kotryna , Göldlin Martina B. , Kurmann Christoph C. , Mujanovic Adnan , Meinel Thomas R. , Kaesmacher Johannes , Seiffge David J. , Jung Simon , Mordasini Pasquale , Fischer Urs , Gralla Jan , Sarikaya Hakan , Goeggel Simonetti Barbara , Antonenko Kateryna , Umarova Roza M. , Bally Lia , Arnold Marcel , Heldner Mirjam R. 
Published: June 2022

AbstractBackground and purposeWe aimed to assess the association of diabetes mellitus (DM) and admission hyperglycaemia (AH), respectively, and outcome in patients with acute ischaemic stroke with large vessel occlusion in the anterior circulation treated with endovascular therapy (EVT) in daily clinical practice.MethodsConsecutive EVT patients admitted to our stroke centre between February 2015 and April 2020 were included in this observational cohort study. Patients with versus without DM and with versus without AH (glucose ≥ 7.8 mmol/L) were compared.ResultsWe included 1020 patients (48.9% women, median age = 73.1 years); 282 (27.6%) had DM, and 226 (22.2%) had AH. Patients with versus without DM less often showed successful reperfusion (odds ratio [OR]adjusted = 0.61, p = 0.023) and worse 3‐month functional outcome (modified Rankin Scale [mRS] = 0–2: 31.3% vs. 48%, ORadjusted = 0.59, p = 0.004; death: 38.9% vs. 24.1%, ORadjusted = 1.75, p = 0.002; mRS shift: padjusted < 0.0001; if moderate/good collaterals and mismatch, mRS = 0–2: ORadjusted = 0.52, p = 0.005; death: ORadjusted = 1.95, p = 0.005). If analysis was additionally adjusted for AH, only mRS shift was still significantly worse in patients with DM (padjusted = 0.012). Patients with versus without AH showed similar successful reperfusion rates and worse 3‐month functional outcome (mRS = 0–2: 28.3% vs. 50.4%, ORadjusted = 0.52, p < 0.0001; death: 40.4% vs. 22.4%, ORadjusted = 1.80, p = 0.001; mRS shift: padjusted < 0.0001; if moderate/good collaterals and mismatch, mRS = 0–2: ORadjusted = 0.38, p < 0.0001; death: ORadjusted = 2.39, p < 0.0001). If analysis was additionally adjusted for DM, 3‐month functional outcome remained significantly worse in patients with AH (mRS = 0–2: ORadjusted = 0.58, p = 0.004; death: ORadjusted = 1.57, p = 0.014; mRS shift: padjusted = 0.004). DM independently predicted recurrent/progressive in‐hospital ischaemic stroke (OR = 1.71, p = 0.043) together with admission National Institutes of Health Stroke Scale score (OR = 0.95, p = 0.005), and AH independently predicted in‐hospital symptomatic intracranial haemorrhage (OR = 2.21, p = 0.001). The association of admission continuous glucose levels and most outcome variables was (inversely) J‐shaped.ConclusionsHyperglycaemia more than DM was associated with worse 3‐month outcome in the patients studied, more likely so in the case of moderate/good collaterals and mismatch in admission imaging.
The Linguistic Embodiment of Emotions. A Study of the Australian Continent
Authors: Ponsonnet Maïa 
Published: June 2022

AbstractThis article describes how particular emotions map figuratively onto body parts in Australian Indigenous languages. While most languages use expressions involving body parts to talk about emotions—as in “broken‐hearted,” for instance—Australian Indigenous languages do it to a remarkable extent. After identifying the figurative tropes—metaphors and metonymies—that recur most frequently in such expressions across the continent, the article discusses specific body‐part associations and figurative patterns for several salient emotional categories. This includes generic emotions (feel good/bad); “empathetic” emotions (affection and derived emotions); anger and sulkiness; social attitudes around agreeableness and compliance; shame; love, desire, and jealousy; and fear and surprise. Far from being randomly distributed, the figurative properties of each category exhibit regular patterns. Some of these patterns reflect somatic and behavioral responses to emotions or cognitive properties of emotions, while others remain unexplained. [Australian languages, emotions, figurative language, embodiment]Résumé Cet article décrit et analyse les correspondances entre catégories émotionnelles et parties du corps dans les expressions figuratives des langues aborigènes australiennes. La majorité des langues du monde utilisent des collocations incluant des parties du corps pour décrire des émotions—comme dans l'expression « cœur brisé » par exemple— mais celles‐ci sont particulièrement nombreuses dans les langues australiennes. Après avoir identifié les tropes—métaphores and métonymies—qui reviennent le plus souvent dans ces expressions à travers le continent, l'article analyse les associations spécifiques entre certaines parties du corps, certains tropes, et certaines catégories émotionnelles. Ces catégories incluent les émotions génériques (se sentir bien/mal) ; les émotions dites « empathétiques » (affection et émotions dérivées) ; la colère et la bouderie ; les tempéramments relationnels comme l'amabilité ou un caractère conciliant ; la honte ; l'amour, le désir et la jalousie ; ainsi que la peur et la surprise. Chacune de ces émotions présente des associations préferentielles avec certaines parties du corps, et des propriétés figuratives récurrentes. Certaines de ces préférences et récurrences renvoient à des réactions somatiques ou comportementales aux émotions en question, d'autres à leurs dimensions cognitives ; et d'autres encore restent inexpliquées.
Cryptic diversity and spatial genetic variation in the coral Acropora tenuis and its endosymbionts across the Great Barrier Reef
Authors: Matias Ambrocio Melvin A. , Popovic Iva , Thia Joshua A. , Cooke Ira R. , Torda Gergely , Lukoschek Vimoksalehi , Bay Line K. , Kim Sun W. , Riginos Cynthia 
Published: June 2022

AbstractGenomic studies are uncovering extensive cryptic diversity within reef‐building corals, suggesting that evolutionarily and ecologically relevant diversity is highly underestimated in the very organisms that structure coral reefs. Furthermore, endosymbiotic algae within coral host species can confer adaptive responses to environmental stress and may represent additional axes of coral genetic variation that are not constrained by taxonomic divergence of the cnidarian host. Here, we examine genetic variation in a common and widespread, reef‐building coral, Acropora tenuis, and its associated endosymbiotic algae along the entire expanse of the Great Barrier Reef (GBR). We use SNPs derived from genome‐wide sequencing to characterize the cnidarian coral host and organelles from zooxanthellate endosymbionts (genus Cladocopium). We discover three distinct and sympatric genetic clusters of coral hosts, whose distributions appear associated with latitude and inshore–offshore reef position. Demographic modelling suggests that the divergence history of the three distinct host taxa ranges from 0.5 to 1.5 million years ago, preceding the GBR's formation, and has been characterized by low‐to‐moderate ongoing inter‐taxon gene flow, consistent with occasional hybridization and introgression typifying coral evolution. Despite this differentiation in the cnidarian host, A. tenuis taxa share a common symbiont pool, dominated by the genus Cladocopium (Clade C). Cladocopium plastid diversity is not strongly associated with host identity but varies with reef location relative to shore: inshore colonies contain lower symbiont diversity on average but have greater differences between colonies as compared with symbiont communities from offshore colonies. Spatial genetic patterns of symbiont communities could reflect local selective pressures maintaining coral holobiont differentiation across an inshore–offshore environmental gradient. The strong influence of environment (but not host identity) on symbiont community composition supports the notion that symbiont community composition responds to habitat and may assist in the adaptation of corals to future environmental change.
Computed tomographic diagnosis of a fracture of the floor of the pelvis in a Thoroughbred foal
Authors: Scilimati Nicola , Schiavo Stefano , Lauteri Eleonora , Beccati Francesca , Angeli Giovanni , Di Meo Antonio , Pepe Marco 
Published: June 2022

SummaryThis case report describes the clinical and diagnostic imaging findings, treatment and outcomes of a 15‐day‐old Thoroughbred foal referred for the evaluation of severe left hindlimb lameness of 8 days' duration. Radiographic examination of the left hindlimb and transcutaneous ultrasonographic examination of the pelvis were unremarkable. A computed tomographic (CT) examination was performed to investigate the proximal aspect of the limb and the pelvis; CT scans of the thorax were also acquired. In this case, CT images allowed detection of a closed, slightly displaced, oblique wedge‐like fracture of the left caudal ramus of the pubis and medial ramus of the ischium, allowing an accurate diagnosis to guide appropriate treatment and prognostication. The foal was treated with anti‐inflammatory drugs and box‐rest. A follow‐up by telephone interview with the trainer 3 years later revealed that the horse is in full athletic activity without any residual gait alteration related to the pelvic fracture.