bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pickle Juice Intervention for Cirrhotic Cramps Reduction: The PICCLES Randomized Controlled Trial
Authors: Tapper Elliot B. , Salim Najat , Baki Jad , Zhao Zhe , Sundaram Vinay , Patwardhan Vilas , Nikirk Samantha J. 
Published: April 2022

INTRODUCTION:
Muscle cramps are common among persons with cirrhosis and associated with poor health-related quality of life. Treatment options are limited. We sought to determine whether pickle juice can improve muscle cramp severity.

METHODS:
We enrolled 82 patients with cirrhosis and a history of >4 muscle cramps in the previous month from December 2020 to December 2021. Patients were randomized 1:1 to sips of pickle juice vs tap water at cramp onset. Our primary outcome assessed at 28 days was the change in cramp severity measured by the visual analog scale for cramps (VAS-cramps, scaled 0–10). Cramps were assessed 10 times over 28 days using interactive text messages. Secondary outcomes included the proportion of days with VAS-cramps <5, change in sleep quality, and global health-related quality of life measured using the EQ-5D.

RESULTS:
Overall, 74 patients completed the trial, aged 56.6 ± 11.5 years, 54% male, 41% with ascites, 38% with encephalopathy, and model for end-stage liver disease—sodium score 11.2 ± 4.9. Many patients were receiving other cramp therapies at baseline. The baseline VAS for cramps was 4.2 ± 3.4, the EQ-5D was 0.80 ± 0.10, and 43% rated sleep as poor. At trial completion, the respective values for the pickle juice and control arms were −2.25 ± 3.61 points on the VAS for cramps, compared with control tap water (−0.36 ± 2.87), P = 0.03; a proportion of cramp-days with VAS-cramps <5 were 46% vs 35% (P = 0.2); and the change in sleep quality was not different (P = 0.1). The end-of-trial EQ-5D was 0.78 ± 0.10 vs 0.80 ± 0.10 (P = 0.3). No differences in weight change were observed for those with and without ascites.

DISCUSSION:
In a randomized trial, sips of pickle brine consumed at cramp onset improve cramp severity without adverse events.
Enhanced service life of existing infrastructure buildings by use of concrete screw anchors as post-installed shear reinforcement
Authors: Lechner Johannes , Feix Jürgen 
Published: April 2022

In the last decades, traffic on railways and roads has increased significantly in Central Europe. On the other hand, the existing infrastructure mainly origins from the late 1950s to the 1970s. This applies also for the existing bridge and tunnel infrastructure which is now up to 60 years old. Due to this age and new standards in the current codes, quite often the amount of shear reinforcement does not fulfil the current design code rules. As a replacement of existing structures is often highly unsustainable, methods to improve the shear strength are needed. Therefore, a new system for post-installed shear reinforcement by the use of concrete screws was developed at the University of Innsbruck in the last years. The idea is to use concrete screw anchors - already known as anchoring element - aspost-installed reinforcement. In over 60 shear tests with girders and slabs the excellent applicability of concrete screw anchors as post-installed shear reinforcement has been proven. Also shear tests with cyclic loading were performed prove the use for dynamically loaded structures, such as bridges. Based on these test results a design approach was determined to meet the Eurocode-2 assessment standards.Several pilot-projects with concrete screws have been realised in Austria and Germany. For example a rail-road-bridge over a German highway with a remaining service life of zero years was strengthened to a new service life of over 20 years. Also a city-centre tunnel in Munich which was erected below a historic building is currently strengthened under ongoing traffic in the tunnel using concrete screw anchors as post-installed reinforcement.
A regulamentação do Ensino Domiciliar (homeschooling) no Brasil e a racionalidade neoliberal
Authors: Vinagre Talita Alcalá , Tótora Silvana Maria Corrêa 
Published: April 2022

Objetiva-se mostrar os efeitos ético-políticos do discurso presente nos Projetos de Lei que preveem a regulamentação do Ensino Domiciliar no Brasil. E como este processo está diretamente relacionado a uma flexibilização da escolarização pública que irá configurar um ajustamento à racionalidade neoliberal. Com referência nos estudos de Michel Foucault e Sylvio Gadelha, propõe-se problematizar as concepções de educação que estão em questão nesse processo de regulamentação do Ensino Domiciliar. Buscaremos mostrar como essa modulação está diretamente atrelada à propagação de uma cultura empreendedora no campo educacional e favorece a difusão de uma ideia de liberdade individual que prescinde de valores como a solidariedade e a cooperação, em consonância com a dimensão pública de toda educação.
Bow structure damage analysis for hybrid coir-glass fiber composite fishing boat hull subjected to front collision load
Authors: Windyandari Aulia , Kurdi Ojo , Sulardjaka  , Tauviqirrahman Mohammad 
Published: April 2022

Abstract
Hybridization of natural and synthetic fibers has the ability to improve composite performance. It means that the combination of natural fibers such as coir, jute, bamboo, and sisal with synthetic or glass fiber can broaden the role of the composite material, especially for structural application. This study developed a finite element simulation to investigate the damage to the bow structure of the fishing boat hull, which was produced using hybrid coir-glass fiber composite (HCGFRP) material subjected to front collision load. The experimental measurement was conducted to determine the mechanical properties of four hybrid composite laminates defined based on the differences in their layers number, fiber types, and orientation angle. Moreover, a numerical simulation model was applied to the traditional fishing boat colliding with fishery harbor quay, and the scenario was defined by varying the boat speed and the types of laminates adopted on the hull structure. The results showed the damage level for the bow structure of the HCGFRP boat due to the collision accidents, while the numerical findings are expected to be used as the basic knowledge in applying the hybrid coir-glass fiber laminates composite as an alternative hull construction material.
Effect of the selected parameters in idealizing material failures under tensile loads: Benchmarks for damage analysis on thin-walled structures
Authors: Prabowo Aditya Rio , Ridwan Ridwan , Tuswan Tuswan , Sohn Jung Min , Surojo Eko , Imaduddin Fitrian 
Published: April 2022

Abstract
The development of the global economy has led to a rise in ship traffic. As a result, the risk of accidents, such as collisions between ships and grounding, has also increased. Different failure criteria to capture these accidents have been introduced by researchers. Therefore, the purpose of this study was to determine the essential distinction between these failure criteria. The simulations suggest that failure criteria based on the maximum stress result in a slightly higher rupture strain value, greater crack propagation, and higher internal energy than those based on the maximum strain. Furthermore, using a larger mesh size compared with the size of the test specimen appears to greatly affect the validity of the simulation results.
A pause in pediatrics: implementation of a pediatric diagnostic time-out
Authors: Yale Sarah C. , Cohen Susan S. , Kliegman Robert M. , Bordini Brett J. 
Published: April 2022

Abstract

Objectives
Diagnostic errors are frequently the product of cognitive biases that arise when heuristic-based approaches fail. The efficiency-thoroughness tradeoff (ETTO) principle states sacrificing thoroughness for efficiency is normal and occurs frequently in medicine. The goal of a diagnostic timeout was to provide an actionable template for when providers transition to an analytical mindset and to help incorporate the ETTO principle during the diagnostic process.

Methods
A diagnostic time-out was adapted for use in pediatric hospital medicine (PHM). In this prospective study, a group of eight PHM providers piloted the time-out in the hospitalized setting. Data was collected over 12 months and descriptive statistics were used for analysis.

Results
Cases were most frequently chosen for time-out use due to clinician intuition. In more than half the cases the time-out didn’t confirm the initial diagnosis and alternate diagnoses for the wrong diagnosis were pursued. There was only one case of the time-out being burdensome from a time perspective. Learners participated in all cases. As a result of the diagnostic time-out, new actions were taken in all cases.

Conclusions
Implementation of a diagnostic time out provides an actionable template for providers to actively change their mindset to an analytical thinking process to counteract cognitive biases and potentially reduce diagnostic errors in the pediatric inpatient setting.
Personal Learning Environments in Online and Face-to-Face Contexts in Mexican Higher Education
Authors: Ramírez-Mera Urith N. , Tur Gemma , Marin Victoria I. 
Published: April 2022

Abstract
With the introduction of digital technologies in education and the diversification of learning modalities, research has sought to identify the characteristics of each modality in order to develop successful learning. The Personal Learning Environment (PLE) is a developing concept that takes advantage of digital technologies and their implications in different modalities. This research aims to identify how the educational modality contributes to the development of PLEs in higher education. We compared two case studies in online and face-to-face contexts in Mexican higher education through a case survey methodology using a questionnaire and a descriptive statistical analysis of five categories: self-perception, management of information, management of the learning process, communication and learning experience. Results show that online students focus on the use of information management skills and on self-regulation of the learning process, whereas face-to-face students are oriented towards the use of communication skills. In conclusion, we identify two PLE profiles whose main differences arise from the students’ learning approaches, one based on social interaction and the other guided by learning aims, two aspects that may contribute to the development of learning strategies for transition between modalities. Finally, we contribute to the support of face-to-face learning in virtual environments and emergency remote teaching.
College music teaching and ideological and political education integration mode based on deep learning
Authors: Wang Xiaoshu , Zhao Suhua , Liu Jingwen , Wang Liyan 
Published: April 2022

Abstract
In order to highlight the role of music teaching in the teaching of ideological and political courses, this study puts forward research on the integration of music teaching and ideological and political teaching. This study analyzes the promotion and necessity of college music teaching to ideological and political work, constructs a fusion model of college music teaching and ideological and political work, introduces deep learning methods, and weakens the influence of errors in the data of college music teaching and ideological and political work. This study also optimized the integration mode of college music teaching and ideological and political work and realized the model research of college music teaching and ideological and political work. The experimental results show that the resource output amplitude controlled by the deep learning method has the best stability, and there is no large amplitude fluctuation during the experiment. The output amplitude and control time of the fusion resource are guaranteed and the fusion path of music teaching and ideological and political education is clearer. The maximum control time of the fusion resource of this method is 23.55 ms.
Safety analysis for integrity enhancement in nuclear power plants (NPPs) in case of seashore region site
Authors: Woo Tae Ho , Baek Chang Hyun , Jang Kyung Bae 
Published: April 2022

Abstract
It is investigated for the seismic consequences in the nuclear power plant (NPP) where the radiological hazard could be one of critical issues when the safety system is in failure. The artificial learning is done during the calculations of each time step. There are the simulations for the artificial neural networking (ANN) as the precision, sensitivity (recall value), specificity, and accuracy which are 21.48%, 50.53%, 25.47%, and 32.68% respectively. Likewise, the recurrent neural network (RNN) modeling has 23.64%, 54.53%, 25.56%, and 34.17% respectively. In the comparisons for ANN and RNN, the values of ANN’s parameters are lower than those of RNN in all values of precision, recall, specificity, and accuracy. As the designed factors for the nuclear matters increase, the estimations could be better in considering the conditional situations.
Strong convergence of a self-adaptive inertial Tseng's extragradient method for pseudomonotone variational inequalities and fixed point problems
Authors: Uzor Victor Amarachi , Alakoya Timilehin Opeyemi , Mewomo Oluwatosin Temitope 
Published: April 2022

Abstract
In this paper, we study the problem of finding a common solution of the pseudomonotone variational inequality problem and fixed point problem for demicontractive mappings. We introduce a new inertial iterative scheme that combines Tseng’s extragradient method with the viscosity method together with the adaptive step size technique for finding a common solution of the investigated problem. We prove a strong convergence result for our proposed algorithm under mild conditions and without prior knowledge of the Lipschitz constant of the pseudomonotone operator in Hilbert spaces. Finally, we present some numerical experiments to show the efficiency of our method in comparison with some of the existing methods in the literature.
Moscatilin suppresses the inflammation from macrophages and T cells
Authors: Zhang Ying , Xu Yugang , Jing Xiujie , Lu Wenkui , Zhang Fusen , Qin Chengkun 
Published: April 2022

Abstract
In this study, we aim to investigate moscatilin in alleviating symptoms of autoimmune liver disease (ALD) in a concanavalin A (ConA)-induced liver injury mouse model and elucidate the underlying mechanisms. ALD mouse models were constructed by intravenous injection of ConA (20 mg/kg) and the serum level of alanine aminotransferase (ALT) was measured using an enzyme-linked immunosorbent assay. Moscatilin in various doses was administered for two days starting from a day before the ConA injection. We showed that moscatilin dose-dependently decreased ALT levels in liver tissue of ALD mouse models. Ifng and Tnfa also showed significant downregulation in liver tissues. Macrophages only showed significant Tnfa downregulation and CD4+ T cells only showed significant Ifng downregulation at high moscatilin doses. In vivo administration of moscatilin induced interleukin-37 upregulation in hepatic tissues. In vitro, moscatilin also induced IL-37 upregulation in hepatic stellate cell line JS-1 rather than immune cells represented by RAW264.7 and CTLL-2 cell lines, suggesting that the hepatic stellate cell is majorly responsive to moscatilin treatment in terms of interleukin (IL)-37 upregulation. Our data indicate that moscatilin could alleviate liver injury in ConA-induced ALD mouse models through anti-inflammatory activities, warranting further development of moscatilin as a new drug in treating ALD.
Analysis of microstructure evolution during heat treatment of CoSm permanent magnets using high-resolution scanning electron microscopy
Authors: Braun Philipp , Laukart Judith , Golla-Schindler Ute , Löffler Ralf , Goll Dagmar , Schneider Gerhard 
Published: April 2022

Abstract
CoSm permanent magnets are characterized by high coercivity, which is due to the formation of a cellular nanostructure. For the understanding and optimization of these magnets, the evolution and morphology of the cellular structure need to be analyzed, most commonly by transmission electron microscopy (TEM). Meanwhile, high-resolution scanning electron microscopy (SEM) is enabling the visualization and large-scale imaging of the nanostructure while requiring relatively little preparation effort, combined with easy sample handling. Different preparation techniques will be used to visualize different microstructural constituents, enabling the analysis of their morphologies and fractions.
Non-destructive Metallurgical Failure Investigation of Erroneously Heat Treated Hot Gas Path Component Using Replica Technique
Authors: Neidel Andreas , Gädicke Tobias , Giller Madeleine 
Published: April 2022

Abstract
Metallic heat shields, used in combustion chambers of heavy-duty gas turbine engines and made of nickel-based superalloys, were accidentally heat treated during fabrication, using wrong parameters. There were concerns about embrittlement. Nondestructive metallurgical material characterization using the replica technique verified embrittlement by secondary phases. In spite of this, it was recommended to the client to use the affected parts as is, this on the grounds that no grain growth was observed and hardness was not elevated. While the case study presented in this contribution may appear trivial at first sight, it interestingly shows how metallographic examinations may sometimes be performed non-destructively, without sacrificing any engine components. The inclined reader should also note the superb quality of the photomicrographs presented in this contribution. They were taken from replica foils, not actual metallographic sections.
Erfassung der Schmelzbadfläche mit Korrektur der Perspektive zur Prozessregelung eines Wire and Arc Additive Manufacturing
Authors: Richter Andreas , Scheck Maxim , Bohn Christian , Rembe Christian 
Published: April 2022

Zusammenfassung
Die additive Fertigung ermöglicht eine flexible Herstellung von Kleinserien oder komplexen Bauteilen. Die Vorteile dieses Verfahren liegen vor allem in der hohen Flexibilität und der Möglichkeit, anspruchsvolle Geometrien zu fertigen. Unter dem Schlagwort 3D-Druck werden dabei verschiedene Verfahren zusammengefasst, die auf Basis eines CAD-Modells lagenweise das Bauteil erzeugen. „Wire and Arc Additive Manufacturing“ (WAAM) nutzt einen Lichtbogenschweißprozess, um das Material schichtweise aufzutragen. Dies ermöglicht höhere Auftragsraten im Vergleich zu pulverbett- und laserbasierten, additiven Fertigungsverfahren bei gleichzeitig geringeren Investitionskosten. Die Wahl der Prozesseinstellgrößen erfolgt größtenteils heuristisch, die mangelnde Wiederholbarkeit verhindert aktuell eine breite Anwendung des WAAM-Verfahrens. Die Verwendung eines geschlossenen Regelkreises bietet die Möglichkeit, auftretende Prozessstörungen direkt auszuregeln und die Wiederholbarkeit zu gewährleisten. Der geschlossene Regelkreis erfordert die Erfassung des Prozesses mit geringer Latenz. In diesem Beitrag stellen wir die Echtzeitmessung der Schmelzbadfläche auf Basis eines selbst entwickelten Quotientenpyrometers, welches das Licht vom Lichtbogen ausblendet, beim Metall-Aktivgasschweißen (MAG) mit Stahl vor. Durch die Echtzeiterfassung kann das Signal für eine Regelung der Schmelzbadfläche verwendet werden.
Anthropometric, Physiological, and Physical Profile of Elite Snowboarding Athletes
Authors: Wang Zhiqiang , Zhong Yaping , Wang Sugai 
Published: April 2022

ABSTRACT
A successful snowboarding performance is a multifactorial accomplishment resulting from a complex interaction of the major fitness components. This review aimed to examine the anthropometric, physiological, and physical profiles of elite snowboarding athletes. A database search was performed in the China National Knowledge Infrastructure, PubMed, SPORT Discus, and Web of Science. The findings indicate that (a) elite speed-based and skill-based athletes generally had low body fat percentages. The height and body mass of men athletes are slightly larger than those of skill-based athletes. (b) The energy system predominantly engaged in is anaerobic metabolism. Muscle oxidative metabolism could help to promote recovery in the repeated high-intensity runs. (c) Top levels of lower-body strength, especially the eccentric force production and explosive concentric power production of athletes, have a determinant role in rapid riding and turning, jump amplitude, trick difficulty, and successful landing. The take-off velocity of skill-based snowboarding and the starting and turning speed of speed-based snowboarding also have a major effect on success in competitions. Further research is warranted to investigate the anthropometry, the relative energy system contributions from aerobic and anaerobic metabolism, and the physical training on performance while considering the possible differentiated effects of different snowboarding disciplines.
SARS-CoV-2 associated liver injury: a six-month follow-up analysis of liver function recovery
Authors: Roman Adina , Moldovan Septimiu , Stoian Mircea , Tilea Brindusa , Dobru Daniela 
Published: April 2022

SARS-CoV-2 associated liver injury: a six-month follow-up analysis of liver function recovery

Background and aims. SARS-CoV-2 infection has raised the interest in clinical and paraclinical research worldwide, representing a public health issue since the beginning of 2020. Studies have established the variable, unpredictable character of COVID-19. Our main objective was to assess the liver function of patients without pre-existing liver disease, diagnosed with SARS-CoV-2 associated liver injury in a 6-month follow-up study after discharge.
Methods. We conducted a prospective paraclinical and imagistic follow-up study between 1st September 2020 and 30th April 2021 on patients without pre-existing liver disease previously diagnosed with SARS-CoV-2 associated liver injury who had been admitted in Mures County Clinical Hospital, Targu Mures, Romania. We followed up patients ’clinical and paraclinical characteristics at index COVID-19 hospitalization and at T1 (6-month follow-up visit).
Results. We performed abdominal ultrasonography and laboratory examinations in 78 patients (mean age 45±10 years) hospitalized 6 months earlier for symptomatic COVID-19, with a male:female ratio of 1.3:1.
Thirty patients (38.46%) were discharged at index COVID-19 hospitalization with abnormal liver function tests, while the rest presented paraclinical normalization at discharge and mean duration of liver injury of approximately 7 days. Follow-up examination revealed abnormal liver function tests in twenty-four patients, most of which presented with mild liver injury. All patients with severe COVID-19 at index hospitalization present with abnormal liver function tests at follow-up examination.
Conclusions. By performing a complete clinical and paraclinical 6-month follow-up study, with a specific focus on 34.6% of patients in which we noted a persistence of liver function tests abnormality, we could analyse a possible long-term effect of SARS-CoV-2 infection over liver function and also raise awareness of liver function tests monitoring and therapeutic management in post COVID-19 patients. Long-term follow-up studies of COVID-19 multi-organ sequelae are therefore mandatory in order to improve the practice of consultant gastroenterologists.