bluuebunny/crossref_metadata_2025_split huggingface dataset:
Schottky‐Contacted High‐Performance GaSb Nanowires Photodetectors Enabled by Lead‐Free All‐Inorganic Perovskites Decoration
Authors: Liu Dong , Liu Fengjing , Liu Yue , Pang Zhiyong , Zhuang Xinming , Yin Yanxue , Dong Shengpan , He Longbing , Tan Yang , Liao Lei , Chen Feng , Yang Zai‐xing 
Published: March 2022

AbstractThe surface Fermi level pinning effect promotes the formation of metal‐independent Ohmic contacts for the high‐speed GaSb nanowires (NWs) electronic devices, however, it limits next‐generation optoelectronic devices. In this work, lead‐free all‐inorganic perovskites with broad bandgaps and low work functions are adopted to decorate the surfaces of GaSb NWs, demonstrating the success in the construction of Schottky‐contacts by surface engineering. Benefiting from the expected Schottky barrier, the dark current is reduced to 2 pA, the Ilight/Idark ratio is improved to 103 and the response time is reduced by more than 15 times. Furthermore, a Schottky‐contacted parallel array GaSb NWs photodetector is also fabricated by the contact printing technology, showing a higher photocurrent and a low dark current of 15 pA, along with the good infrared photodetection ability for a concealed target. All results guide the construction of Schottky‐contacts by surface decorations for next‐generation high‐performance III–V NWs optoelectronics devices.
Toward sustainable express deliveries for online shopping: Reusing packaging materials through reverse logistics
Authors: Lai Nai Yeen Gavin , Kuah Adrian T. H. , Kim Chang H. , Wong Kok Hoong 
Published: March 2022

AbstractThe COVID‐19 pandemic has led to an increase in online purchases, which has inevitably raised the demand for express delivery packaging materials (EDPMs). This study proposes a reverse logistics reuse framework that extends the EDPM life cycle by drawing on insights and conclusions from a review of the literature on supply chain management and materials science to achieve a sustainable e‐commerce system. A key benefit of reverse logistics is its effectiveness in exploiting opportunities for resource reuse, which is preferred to recycling. By extending service life through resource optimization, recycling, and recovery processes, the novel reuse framework based on reverse logistics can be implemented with minimal changes to existing forward logistics systems, potentially leading to more sustainable online shopping. This study proposes a novel combination of reusable packaging materials and reverse logistics as a viable and more environmentally friendly practice, in line with circular economy goals.
LINC01588 regulates WWP2‐mediated cardiomyocyte injury by interacting with HNRNPL
Authors: Song Yanbin , Ren Xiaoyue , Gao Feng , Li Fei , Zhou Jing , Chen Junmin , Zhang Yunqing 
Published: March 2022

AbstractCardiomyocyte dysfunction and apoptosis induced by ischemia–hypoxia are common features of many acute and chronic heart diseases. WW domain‐containing E3 ubiquitin ligase (WWP2) has been identified as an important regulator in pathogenesis of some health‐threatening diseases. Although a couple of recent reports prompted the potential role of WWP2 in heart dysfunction, however, its exact role and how its expression was regulated in ischemic–hypoxic cardiomyocytes are still elusive. Here, we found that WWP2 protein level was induced in anoxia/reoxygenation (A/R) treated cardiomyocytes in a time‐dependent manner, accompanied by synchronous expression of LINC01588 and HNRNPL. Knockdown of LINC01588 increased cardiomyocyte apoptosis, the level of oxidative stress, and expression of pro‐inflammatory cytokine genes, down‐regulated the expression of WWP2 and promoted expression of SEPT4 gene that contributed to cardiomyocyte dysfunction and was a target gene of WWP2. LINC01588 overexpression improved the functions of A/R treated cardiomyocytes, up‐regulated WWP2 and reduced SEPT4 expression. In the mechanism exploration, we found that LINC01588 could directly bind with HNRNPL protein that could interact with WWP2, suggesting that WWP2 was involved in the regulation of LINC01588 in A/R treated cardiomyocytes. Moreover, WWP2 inhibition declined the protective role of LINC01588 in cardiomyocyte dysfunction induced by A/R. Finally, we demonstrated that LINC01588 overexpression improved acute myocardial infarction in mice in vivo. In conclusion, LINC01588 improved A/R‐induced cardiomyocyte dysfunction by interacting with HNRNPL and promoting WWP2‐mediated degradation of SEPT4.
Professional stereotypes among specialties and fields of work within the veterinary community
Authors: Agathou Sylvia , Stratis Andreas , Routh Jennifer , Paramasivam Sharmini J. 
Published: March 2022

AbstractBackgroundMedical specialties hold varying degrees of prestige, stemming from the existence of stereotypes among them. These have been shown to lead to prejudice against specific specialists, which not only influences career choices but also affects the perception of equality among specialties.MethodThe aim of the research was to determine the presence of stereotypes in the UK veterinary community. Using an online questionnaire, participants were asked to provide an adjective that best characterises 15 specialties, in addition to their perceptions on prestige and gender association. Word cloud analysis coupled with sentiment analysis in Python using the language processing software Natural Language Toolkit (NLTK) was used to assess sentiments with respect to the adjectives.ResultsThere were 665 questionnaire respondents, and there was evidence of their construction of specialty‐specific stereotypes. Some specialties were perceived more negatively than others, including equine general practitioners, surgeons, pathologists, dermatologists and public health veterinarians/epidemiologists. Gender bias was identified within this study, most prominently within production animal and behavioural medicine veterinarians. The most prestigious specialties were neurology, surgery and cardiology.ConclusionSpecialty‐specific stereotypes exist within the veterinary community. Acknowledging their existence is a first step to recognising the influence they have on career choices.
Mixed correlator dispersive CFT sum rules
Authors: Trinh Anh-Khoi 
Published: March 2022

Abstract
Conformal field theory (CFT) dispersion relations reconstruct correlators in terms of their double discontinuity. When applied to the crossing equation, such dispersive transforms lead to sum rules that suppress the double-twist sector of the spectrum and enjoy positivity properties at large twist. In this paper, we construct dispersive CFT functionals for correlators of unequal scalar operators in position- and Mellin-space. We then evaluate these functionals in the Regge limit to construct mixed correlator holographic CFT functionals which probe scalar particle scattering in Anti-de Sitter spacetime. Finally, we test properties of these dispersive sum rules when applied to the 3D Ising model, and we use truncated sum rules to find approximate solutions to the crossing equation.
Shaping contours of entanglement islands in BCFT
Authors: Ageev Dmitry S. 
Published: March 2022

Abstract
In this paper, we study the fine structure of entanglement in holographic two-dimensional boundary conformal field theories (BCFT) in terms of the spatially resolved quasilocal extension of entanglement entropy — entanglement contour. We find that the boundary induces discontinuities in the contour revealing hidden localization-delocalization patterns of the entanglement degrees of freedom. Moreover, we observe the formation of “islands” where the entanglement contour vanishes identically implying that these regions do not contribute to the entanglement at all. We argue that these phenomena are the manifestation of the entanglement islands recently discussed in the literature. We apply the entanglement contour proposal to the recently discussed BCFT black hole models reproducing the Page curve — moving mirror model and the pair of BCFT in the thermofield double state. From the viewpoint of entanglement contour, the Page curve also carries the imprint of strong delocalization caused by dynamical entanglement islands.
Scotogenic neutrino masses with gauged matter parity and gauge coupling unification
Authors: Cárcamo Hernández A. E. , Hati Chandan , Kovalenko Sergey , Valle José W. F. , Vaquera-Araujo Carlos A. 
Published: March 2022

Abstract
Building up on previous work we propose a Dark Matter (DM) model with gauged matter parity and dynamical gauge coupling unification, driven by the same physics responsible for scotogenic neutrino mass generation. Our construction is based on the extended gauge group SU(3)c ⊗ SU(3)L ⊗ U(1)X ⊗ U(1)N, whose spontaneous breaking leaves a residual conserved matter parity, MP, stabilizing the DM particle candidates of the model. The key role is played by Majorana SU(3)L-octet leptons, allowing the successful gauge coupling unification and a one-loop scotogenic neutrino mass generation. Theoretical consistency allows for a plethora of new particles at the ≲ $$ \mathcal{O} $$
O
(10) TeV scale, hence accessible to future collider and low-energy experiments.
Cosmology from confinement?
Authors: Van Raamsdonk Mark 
Published: March 2022

Abstract
We describe a class of holographic models that may describe the physics of certain four-dimensional big-bang/big-crunch cosmologies. The construction involves a pair of 3D Euclidean holographic CFTs each on a homogeneous and isotropic space M coupled at either end of an interval ℐ to a Euclidean 4D CFT on M × ℐ with many fewer local degrees of freedom. We argue that in some cases, when the size of M is much greater than the length of ℐ, the theory flows to a confining three-dimensional field theory on M in the infrared, and this is reflected in the dual description by the asymptotically AdS spacetimes dual to the two 3D CFTs joining up in the IR to give a Euclidean wormhole. The Euclidean construction can be reinterpreted as generating a state of the Lorentzian 4D CFT on M × time whose dual includes the physics of a big-bang/big-crunch cosmology. When M is ℝ3, we can alternatively analytically continue one of the ℝ3 directions to get an eternally traversable four-dimensional planar wormhole. We suggest explicit microscopic examples where the 4D CFT is $$ \mathcal{N} $$
N
= 4 SYM theory and the 3D CFTs are superconformal field theories with opposite orientation. In this case, the two geometries dual to the pair of 3D SCFTs can be understood as a geometrical version of a brane-antibrane pair, and the tendency of the geometries to connect up is related to the standard instability of brane-antibrane systems.
Hirntod erleben, ärztliche Sichtweise – ein phänomenologischer Ansatz
Authors: Drexler Sabine , Farin-Glattacker Erik , Kugler Christiane 
Published: March 2022

Zusammenfassung
Ziel
Ziel der vorliegenden Studie war die Untersuchung des Erlebens von Ärzten bei der Betreuung von (potenziell) hirntoten Patienten.

Methodik
Durchgeführt wurden episodische Interviews. Die Auswertung fand in Anlehnung an die interpretative Phänomenologie nach Benner statt.

Ergebnisse
Elf Ärzte haben an den Interviews teilgenommen. Folgende Phänomene konnten aus den Daten gewonnen werden: 1) Begegnungen mit den Angehörigen, 2) Angehörigen den Hirntod begreiflich machen, 3) Hirntod ist Tod, 4) Erleben der Pflegenden und 5) Belastungen.

Schlussfolgerung
Die Ergebnisse zeigen die Komplexität, die bei der Betreuung eines (potenziell) hirntoten Patienten aus Sicht der Ärzte wahrgenommen wird. Der Übergang vom Erhalt des Lebens des Patienten zum Organerhalten oder zum Abstellen der Geräte und die dazugehörige Aufklärung der Angehörigen erfordern hohe Kompetenzen der Ärzte. Symptome der Patienten geben den Ärzten klare diagnostische Vorgehensweisen, bestehende Unklarheiten im (Behandlungs‑)Prozess sollten behoben werden.
Seeing the good in the bad: actual clinical outcome of thrombectomy stroke patients with formally unfavorable outcome
Authors: Blum Friederike , Hager Charlotte , Taufik Homan , Wiesmann Martin , Hasan Dimah , Reich Arno , Pinho João , Nikoubashman Omid 
Published: March 2022

Abstract
Purpose
Clinical outcome of stroke patients is usually classified into favorable (modified Rankin scale (mRS) 0–2) and unfavorable (mRS 3–5) outcome according to the modified Rankin scale. We took a closer look at the clinical course of thrombectomy stroke patients with formal unfavorable outcome and assessed whether we could achieve our treatment goals and/or neurological improvement in these patients.

Methods
We studied 107 patients with occlusions in the terminal carotid artery or the M1 segment of the middle cerebral artery, in whom complete recanalization (eTICI 3) could be achieved, and who had an mRS of 3–5 at 90 days. We analyzed whether an individual treatment goal (i.e., preventing aphasia) and neurological improvement (NIHSS) could be achieved. In addition, we examined whether there was clinical improvement on the mRS.

Results
The treatment goal was achieved in 52% (53/103) and neurological improvement in 65% (67/103). mRS 90 days post-stroke was better than mRS upon admission in 36% (38/107) and better than or equal to mRS upon admission in 80% (86/107). Of the 93 patients with known pre-stroke mRS, 18% (17/93) already had an mRS ≥ 3, with 15 of these 17 patients having a worse mRS on admission than before. Of these 17 patients, 18% regained baseline, and 24% improved from admission.

Conclusion
Dichotomizing the mRS into favorable and unfavorable outcome does not do justice to the full spectrum of stroke. Patients with formal unfavorable outcome after mRS can improve neurologically, achieve treatment goals, and even regain their admission or pre-stroke mRS.
Antiarrhythmic Medication in Neonates and Infants with Supraventricular Tachycardia
Authors: Bruder Diana , Weber Roland , Gass Matthias , Balmer Christian , Cavigelli-Brunner Anna 
Published: March 2022

AbstractSupraventricular tachycardia (SVT) is the most common arrhythmia in neonates and infants, and pharmacological therapy is recommended to prevent recurrent episodes. This retrospective study aims to describe and analyze the practice patterns, effectiveness, and outcome of drug therapy for SVT in patients within the first year of life. Among the 67 patients analyzed, 48 presented with atrioventricular re-entrant tachycardia, 18 with focal atrial, and one with atrioventricular nodal re-entrant. Fetal tachycardia was reported in 27%. Antiarrhythmic treatment consisted of beta-receptor blocking agents in 42 patients, propafenone in 20, amiodarone in 20, and digoxin in 5. Arrhythmia control was achieved with single drug therapy in 70% of the patients, 21% needed dual therapy, and 6% triple. Propafenone was discontinued in 7 infants due to widening of the QRS complex. After 12 months (6–60), 75% of surviving patients were tachycardia-free and discontinued prophylactic treatment. Patients with fetal tachycardia had a significantly higher risk of persistent tachycardia (p: 0.007). Prophylactic antiarrhythmic medication for SVT in infancy is safe and well tolerated. Arrhythmia control is often achieved with single medication, and after cessation, most patients are free of arrhythmias. Infants with SVT and a history of fetal tachycardia are more prone to suffer from persistent SVT and relapses after cessation of prophylactic antiarrhythmic medication than infants with the first episode of SVT after birth.
Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients
Authors: Haupt Luis Peter , Rebs Sabine , Maurer Wiebke , Hübscher Daniela , Tiburcy Malte , Pabel Steffen , Maus Andreas , Köhne Steffen , Tappu Rewati , Haas Jan , Li Yun , Sasse Andre , Santos Celio C. X. , Dressel Ralf , Wojnowski Leszek , Bunt Gertrude , Möbius Wiebke , Shah Ajay M. , Meder Benjamin , Wollnik Bernd , Sossalla Samuel , Hasenfuss Gerd , Streckfuss-Bömeke Katrin 
Published: March 2022

AbstractCancer therapies with anthracyclines have been shown to induce cardiovascular complications. The aims of this study were to establish an in vitro induced pluripotent stem cell model (iPSC) of anthracycline-induced cardiotoxicity (ACT) from patients with an aggressive form of B-cell lymphoma and to examine whether doxorubicin (DOX)-treated ACT-iPSC cardiomyocytes (CM) can recapitulate the clinical features exhibited by patients, and thus help uncover a DOX-dependent pathomechanism. ACT-iPSC CM generated from individuals with CD20+ B-cell lymphoma who had received high doses of DOX and suffered cardiac dysfunction were studied and compared to control-iPSC CM from cancer survivors without cardiac symptoms. In cellular studies, ACT-iPSC CM were persistently more susceptible to DOX toxicity including augmented disorganized myofilament structure, changed mitochondrial shape, and increased apoptotic events. Consistently, ACT-iPSC CM and cardiac fibroblasts isolated from fibrotic human ACT myocardium exhibited higher DOX-dependent reactive oxygen species. In functional studies, Ca2+ transient amplitude of ACT-iPSC CM was reduced compared to control cells, and diastolic sarcoplasmic reticulum Ca2+ leak was DOX-dependently increased. This could be explained by overactive CaMKIIδ in ACT CM. Together with DOX-dependent augmented proarrhythmic cellular triggers and prolonged action potentials in ACT CM, this suggests a cellular link to arrhythmogenic events and contractile dysfunction especially found in ACT engineered human myocardium. CamKIIδ inhibition prevented proarrhythmic triggers in ACT. In contrast, control CM upregulated SERCA2a expression in a DOX-dependent manner, possibly to avoid heart failure conditions. In conclusion, we developed the first human patient-specific stem cell model of DOX-induced cardiac dysfunction from patients with B-cell lymphoma. Our results suggest that DOX-induced stress resulted in arrhythmogenic events associated with contractile dysfunction and finally in heart failure after persistent stress activation in ACT patients.
Different strategies in pointing tasks and their impact on clinical bedside tests of spatial orientation
Authors: Gerb J. , Brandt T. , Dieterich M. 
Published: March 2022

AbstractDeficits in spatial memory, orientation, and navigation are often early or neglected signs of degenerative and vestibular neurological disorders. A simple and reliable bedside test of these functions would be extremely relevant for diagnostic routine. Pointing at targets in the 3D environment is a basic well-trained common sensorimotor ability that provides a suitable measure. We here describe a smartphone-based pointing device using the built-in inertial sensors for analysis of pointing performance in azimuth and polar spatial coordinates. Interpretation of the vectors measured in this way is not trivial, since the individuals tested may use at least two different strategies: first, they may perform the task in an egocentric eye-based reference system by aligning the fingertip with the target retinotopically or second, by aligning the stretched arm and the index finger with the visual line of sight in allocentric world-based coordinates similar to using a rifle. The two strategies result in considerable differences of target coordinates. A pilot test with a further developed design of the device and an app for a standardized bedside utilization in five healthy volunteers revealed an overall mean deviation of less than 5° between the measured and the true coordinates. Future investigations of neurological patients comparing their performance before and after changes in body position (chair rotation) may allow differentiation of distinct orientational deficits in peripheral (vestibulopathy) or central (hippocampal or cortical) disorders.
Impact of preoperative weight loss achieved by gastric balloon on peri- and postoperative outcomes of bariatric surgery in super-obese patients: a retrospective matched-pair analysis
Authors: Hering Ilona , Dörries Luise , Flemming Sven , Krietenstein Laura , Koschker Ann-Kathrin , Fassnacht Martin , Germer Christoph-Thomas , Hankir Mohammed K. , Seyfried Florian 
Published: March 2022

Abstract
Background
An intragastric balloon is used to cause weight loss in super-obese patients (BMI > 60 kg/m2) prior to bariatric surgery. Whether weight loss from intragastric balloon influences that from bariatric surgery is poorly studied.

Methods
In this retrospective, single-center study, the effects of intragastric balloon in 26 patients (BMI 69.26 ± 6.81) on weight loss after bariatric surgery (primary endpoint), postoperative complications within 30 days, hospital readmission, operation time, and MTL30 (secondary endpoints) were evaluated. Fifty-two matched-pair patients without intragastric balloon prior to bariatric surgery were used as controls.

Results
Intragastric balloon resulted in a weight loss of 17.3 ± 14.1 kg (BMI 5.75 ± 4.66 kg/m2) with a nadir after 5 months. Surgical and postoperative outcomes including complications were comparable between both groups. Total weight loss was similar in both groups (29.0% vs. 32.2%, p = 0.362). Direct postoperative weight loss was more pronounced in the control group compared to the gastric balloon group (29.16 ± 7.53% vs 23.78 ± 9.89% after 1 year, p < 0.05 and 32.13 ± 10.5% vs 22.21 ± 10.9% after 2 years, p < 0.05), who experienced an earlier nadir and started to regain weight during the follow-up.

Conclusion
A multi-stage therapeutic approach with gastric balloon prior to bariatric surgery in super-obese patients may be effective to facilitate safe surgery. However, with the gastric balloon, pre-treated patients experienced an attenuated postoperative weight loss with an earlier nadir and earlier body weight regain. This should be considered when choosing the appropriate therapeutic regime and managing patients’ expectations.