bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blue LED-pumped intense short-wave infrared luminescence based on Cr3+-Yb3+-co-doped phosphors
Authors: Zhang Yan , Miao Shihai , Liang Yanjie , Liang Chao , Chen Dongxun , Shan Xihui , Sun Kangning , Wang Xiao-Jun 
Published: May 2022

AbstractThe growing demand for spectroscopy applications in the areas of agriculture, retail and healthcare has led to extensive research on infrared light sources. The ability of phosphors to absorb blue light from commercial LED and convert the excitation energy into long-wavelength infrared luminescence is crucial for the design of cost-effective and high-performance phosphor-converted infrared LEDs. However, the lack of ideal blue-pumped short-wave infrared (SWIR) phosphors with an emission peak longer than 900 nm greatly limits the development of SWIR LEDs using light converter technology. Here we have developed a series of SWIR-emitting materials with high luminescence efficiency and excellent thermal stability by co-doping Cr3+-Yb3+ ion pairs into Lu0.2Sc0.8BO3 host materials. Benefitting from strong light absorption of Cr3+ in the blue waveband and very efficient Cr3+→Yb3+ energy transfer, the as-synthesized Lu0.2Sc0.8BO3:Cr3+,Yb3+ phosphor emits intense SWIR light in the 900–1200 nm from Yb3+ under excitation with blue light at ~460 nm. The optimized phosphor presents an internal quantum yield of 73.6% and the SWIR luminescence intensity at 100 °C can still keep 88.4% of the starting value at 25 °C. SWIR LED prototype device based on Lu0.2Sc0.8BO3:Cr3+,Yb3+ phosphor exhibits exceptional luminescence performance, delivering SWIR radiant power of 18.4 mW with 9.3% of blue-to-SWIR power conversion efficiency and 5.0% of electricity-to-SWIR light energy conversion efficiency at 120 mA driving current. Moreover, under the illumination of high-power SWIR LED, covert information identification and night vision lighting have been realized, demonstrating a very bright prospect for practical applications.
Localised structuring of metal-semiconductor cores in silica clad fibres using laser-driven thermal gradients
Authors: Song Seunghan , Laurell Fredrik , Meehan Bailey , Hawkins Thomas W. , Ballato John , Gibson Ursula J. 
Published: May 2022

AbstractThe molten core drawing method allows scalable fabrication of novel core fibres with kilometre lengths. With metal and semiconducting components combined in a glass-clad fibre, CO2 laser irradiation was used to write localised structures in the core materials. Thermal gradients in axial and transverse directions allowed the controlled introduction, segregation and chemical reaction of metal components within an initially pure silicon core, and restructuring of heterogeneous material. Gold and tin longitudinal electrode fabrication, segregation of GaSb and Si into parallel layers, and Al doping of a GaSb core were demonstrated. Gold was introduced into Si fibres to purify the core or weld an exposed fibre core to a Si wafer. Ga and Sb introduced from opposite ends of a silicon fibre reacted to form III-V GaSb within the Group IV Si host, as confirmed by structural and chemical analysis and room temperature photoluminescence.
Cryo-EM structure of human glucose transporter GLUT4
Authors: Yuan Yafei , Kong Fang , Xu Hanwen , Zhu Angqi , Yan Nieng , Yan Chuangye 
Published: May 2022

AbstractGLUT4 is the primary glucose transporter in adipose and skeletal muscle tissues. Its cellular trafficking is regulated by insulin signaling. Failed or reduced plasma membrane localization of GLUT4 is associated with diabetes. Here, we report the cryo-EM structures of human GLUT4 bound to a small molecule inhibitor cytochalasin B (CCB) at resolutions of 3.3 Å in both detergent micelles and lipid nanodiscs. CCB-bound GLUT4 exhibits an inward-open conformation. Despite the nearly identical conformation of the transmembrane domain to GLUT1, the cryo-EM structure reveals an extracellular glycosylation site and an intracellular helix that is invisible in the crystal structure of GLUT1. The structural study presented here lays the foundation for further mechanistic investigation of the modulation of GLUT4 trafficking. Our methods for cryo-EM analysis of GLUT4 will also facilitate structural determination of many other small size solute carriers.
CO2/carbonate-mediated electrochemical water oxidation to hydrogen peroxide
Authors: Fan Lei , Bai Xiaowan , Xia Chuan , Zhang Xiao , Zhao Xunhua , Xia Yang , Wu Zhen-Yu , Lu Yingying , Liu Yuanyue , Wang Haotian 
Published: May 2022

AbstractElectrochemical water oxidation reaction (WOR) to hydrogen peroxide (H2O2) via a 2e− pathway provides a sustainable H2O2 synthetic route, but is challenged by the traditional 4e− counterpart of oxygen evolution. Here we report a CO2/carbonate mediation approach to steering the WOR pathway from 4e− to 2e−. Using fluorine-doped tin oxide electrode in carbonate solutions, we achieved high H2O2 selectivity of up to 87%, and delivered unprecedented H2O2 partial currents of up to 1.3 A cm−2, which represents orders of magnitude improvement compared to literature. Molecular dynamics simulations, coupled with electron paramagnetic resonance and isotope labeling experiments, suggested that carbonate mediates the WOR pathway to H2O2 through the formation of carbonate radical and percarbonate intermediates. The high selectivity, industrial-relevant activity, and good durability open up practical opportunities for delocalized H2O2 production.
Amazonian terrestrial water balance inferred from satellite-observed water vapor isotopes
Authors: Shi Mingjie , Worden John R. , Bailey Adriana , Noone David , Risi Camille , Fu Rong , Worden Sarah , Herman Robert , Payne Vivienne , Pagano Thomas , Bowman Kevin , Bloom A. Anthony , Saatchi Sassan , Liu Junjie , Fisher Joshua B. 
Published: May 2022

AbstractAtmospheric humidity and soil moisture in the Amazon forest are tightly coupled to the region’s water balance, or the difference between two moisture fluxes, evapotranspiration minus precipitation (ET-P). However, large and poorly characterized uncertainties in both fluxes, and in their difference, make it challenging to evaluate spatiotemporal variations of water balance and its dependence on ET or P. Here, we show that satellite observations of the HDO/H2O ratio of water vapor are sensitive to spatiotemporal variations of ET-P over the Amazon. When calibrated by basin-scale and mass-balance estimates of ET-P derived from terrestrial water storage and river discharge measurements, the isotopic data demonstrate that rainfall controls wet Amazon water balance variability, but ET becomes important in regulating water balance and its variability in the dry Amazon. Changes in the drivers of ET, such as above ground biomass, could therefore have a larger impact on soil moisture and humidity in the dry (southern and eastern) Amazon relative to the wet Amazon.
Immunogenicity and safety of an intradermal ChAdOx1 nCoV-19 boost in a healthy population
Authors: Pinpathomrat Nawamin , Intapiboon Porntip , Seepathomnarong Purilap , Ongarj Jomkwan , Sophonmanee Ratchanon , Hengprakop Jariya , Surasombatpattana Smonrapat , Uppanisakorn Supattra , Mahasirimongkol Surakameth , Sawaengdee Waritta , Phumiamorn Supaporn , Sapsutthipas Sompong , Kongkamol Chanon , Ingviya Thammasin , Sangsupawanich Pasuree , Chusri Sarunyou 
Published: May 2022

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Two doses of an inactivated SARS-CoV-2 vaccine (CoronaVac) have been shown to be insufficient to protect against variants of concern (VOCs), while viral vector vaccines remain protective against the infection. Herein, we conducted a preliminary study to evaluate the safety and immunity in an adult population who received the conventional 2 dosage-regimen of inactivated SARS-CoV-2 vaccine; with an additional intradermal ChAdOx1 nCoV-19 reciprocal dosage (1:5). An Intramuscular ChAdOx1 nCoV-19 booster was also included as a control. Immediate and delayed local reactions were frequently observed in the fractional intradermal boost, but systemic side effects were significantly decreased compared to the conventional intramuscular boost. The anti-RBD-IgG levels, the neutralising function against delta variants, and T cell responses were significantly increased after boosting via both routes. Interestingly, the shorter interval elicited higher immunogenicity compared to the extended interval. Taken together, a reciprocal dosage of intradermal ChAdOx1 nCoV-19 booster reduces systemic adverse reactions and enhances non inferiority humoral and cellular immune responses compared to a full dose of intramuscular boosting. These findings provide for an effective vaccine management during the shortages of vaccine supply.
Giant magnetochiral anisotropy from quantum-confined surface states of topological insulator nanowires
Authors: Legg Henry F. , Rößler Matthias , Münning Felix , Fan Dingxun , Breunig Oliver , Bliesener Andrea , Lippertz Gertjan , Uday Anjana , Taskin A. A. , Loss Daniel , Klinovaja Jelena , Ando Yoichi 
Published: May 2022

AbstractWireless technology relies on the conversion of alternating electromagnetic fields into direct currents, a process known as rectification. Although rectifiers are normally based on semiconductor diodes, quantum mechanical non-reciprocal transport effects that enable a highly controllable rectification were recently discovered1–9. One such effect is magnetochiral anisotropy (MCA)6–9, in which the resistance of a material or a device depends on both the direction of the current flow and an applied magnetic field. However, the size of rectification possible due to MCA is usually extremely small because MCA relies on inversion symmetry breaking that leads to the manifestation of spin–orbit coupling, which is a relativistic effect6–8. In typical materials, the rectification coefficient γ due to MCA is usually ∣γ∣ ≲ 1 A−1 T−1 (refs. 8–12) and the maximum values reported so far are ∣γ∣ ≈ 100 A−1 T−1 in carbon nanotubes13 and ZrTe5 (ref. 14). Here, to overcome this limitation, we artificially break the inversion symmetry via an applied gate voltage in thin topological insulator (TI) nanowire heterostructures and theoretically predict that such a symmetry breaking can lead to a giant MCA effect. Our prediction is confirmed via experiments on thin bulk-insulating (Bi1−xSbx)2Te3 (BST) TI nanowires, in which we observe an MCA consistent with theory and ∣γ∣ ≈ 100,000 A−1 T−1, a very large MCA rectification coefficient in a normal conductor.
Safety and antiviral activity of triple combination broadly neutralizing monoclonal antibody therapy against HIV-1: a phase 1 clinical trial
Authors: Julg Boris , Stephenson Kathryn E. , Wagh Kshitij , Tan Sabrina C. , Zash Rebecca , Walsh Stephen , Ansel Jessica , Kanjilal Diane , Nkolola Joseph , Walker-Sperling Victoria E. K. , Ophel Jasper , Yanosick Katherine , Borducchi Erica N. , Maxfield Lori , Abbink Peter , Peter Lauren , Yates Nicole L. , Wesley Martina S. , Hassell Tom , Gelderblom Huub C. , deCamp Allen , Mayer Bryan T. , Sato Alicia , Gerber Monica W. , Giorgi Elena E. , Gama Lucio , Koup Richard A. , Mascola John R. , Monczor Ana , Lupo Sofia , Rolle Charlotte-Paige , Arduino Roberto , DeJesus Edwin , Tomaras Georgia D. , Seaman Michael S. , Korber Bette , Barouch Dan H. 
Published: May 2022

AbstractHIV-1 therapy with single or dual broadly neutralizing antibodies (bNAbs) has shown viral escape, indicating that at least a triple bNAb therapy may be needed for robust suppression of viremia. We performed a two-part study consisting of a single-center, randomized, double-blind, dose-escalation, placebo-controlled first-in-human trial of the HIV-1 V2-glycan-specific antibody PGDM1400 alone or in combination with the V3-glycan-specific antibody PGT121 in 24 adults without HIV in part 1, as well as a multi-center, open-label trial of the combination of PGDM1400, PGT121 and the CD4-binding-site antibody VRC07-523LS in five viremic adults living with HIV not on antiretroviral therapy (ART) in part 2 (NCT03205917). The primary endpoints were safety, tolerability and pharmacokinetics for both parts and antiviral activity among viremic adults living with HIV and not on ART for part 2 of the study. The secondary endpoints were changes in CD4+ T cell counts and development of HIV-1 sequence variations associated with PGDM1400, PGT121 and VRC07-523LS resistance in part 2. Intravenously administered PGDM1400 was safe and well-tolerated at doses up to 30 mg kg−1 and when given in combination with PGT121 and VRC07-523LS. A single intravenous infusion of 20 mg kg−1 of each of the three antibodies reduced plasma HIV RNA levels in viremic individuals by a maximum mean of 2.04 log10 copies per ml; however, viral rebound occurred in all participants within a median of 20 days after nadir. Rebound viruses demonstrated partial to complete resistance to PGDM1400 and PGT121 in vitro, whereas susceptibility to VRC07-523LS was preserved. Viral rebound occurred despite mean VRC07-523LS serum concentrations of 93 µg ml−1. The trial met the pre-specified endpoints. Our data suggest that future bNAb combinations likely need to achieve broad antiviral activity, while also maintaining high serum concentrations, to mediate viral control.
A studyforrest extension, MEG recordings while watching the audio-visual movie “Forrest Gump”
Authors: Liu Xingyu , Dai Yuxuan , Xie Hailun , Zhen Zonglei 
Published: May 2022

AbstractNaturalistic stimuli, such as movies, are being increasingly used to map brain function because of their high ecological validity. The pioneering studyforrest and other naturalistic neuroimaging projects have provided free access to multiple movie-watching functional magnetic resonance imaging (fMRI) datasets to prompt the community for naturalistic experimental paradigms. However, sluggish blood-oxygenation-level-dependent fMRI signals are incapable of resolving neuronal activity with the temporal resolution at which it unfolds. Instead, magnetoencephalography (MEG) measures changes in the magnetic field produced by neuronal activity and is able to capture rich dynamics of the brain at the millisecond level while watching naturalistic movies. Herein, we present the first public prolonged MEG dataset collected from 11 participants while watching the 2 h long audio-visual movie “Forrest Gump”. Minimally preprocessed data was also provided to facilitate the use of the dataset. As a studyforrest extension, we envision that this dataset, together with fMRI data from the studyforrest project, will serve as a foundation for exploring the neural dynamics of various cognitive functions in real-world contexts.
Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination
Authors: Cohen Taylor S. , Kelly Elizabeth J. , Nylander Sven , Bansal Himanshu , Jepson Brett M. , Bhuyan Prakash , Sobieszczyk Magdalena E. , Falsey Ann R. 
Published: May 2022

AbstractRare cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported after AZD1222. Anti-platelet factor-4 (PF4) antibodies were observed in patients following presentation of TTS, however it is unclear if AZD1222 was responsible for inducing production of anti-PF4. Paired samples (baseline and day-15) from a phase 3 trial of AZD1222 vs placebo were analyzed for anti-PF4 levels; 19/1727 (1.1%, AZD1222) vs 7/857 (0.8%, placebo) participants were anti-PF4-IgG-negative at baseline but had moderate Day-15 levels (P = 0.676) and 0/35 and 1/20 (5.0%) had moderate levels at baseline but high Day-15 levels. These data indicate that AZD1222 does not induce a clinically relevant general increase in anti-PF4 IgG.
Closed-wound negative pressure therapy dressing after loop ostomy closure: a retrospective comparative study
Authors: Curchod P. , Clerc D. , Jurt J. , Hubner M. , Hahnloser D. , Demartines N. , Grass F. 
Published: May 2022

AbstractClosed-wound negative pressure wound therapy (NPWT) dressings were recently introduced with the purpose to reduce incisional surgical site infections (iSSI) in high-risk wounds. The aim of this study was to compare iSSI rates in patients after ostomy closure with and without additional application of a closed-wound NPWT dressing. Single-center retrospective analysis of consecutive patients undergoing ileo- or colostomy closure over an 8-year period (January 2013—January 2021). Intradermal non-purse string technique with absorbable sutures were used in all patients. Since November 2018, all patients (study group) received a NPWT device for a maximum of 5 days postoperatively (PICO, SMITH AND NEPHEW). Primary outcome was iSSI rate within 30 days of surgery. SSI was defined in accordance with the Center of Disease Control (CDC) classification and included superficial and deep incisional SSI. Data was retrieved from the institutional enhanced recovery after surgery (ERAS) database, with standardized complication assessment by trained abstractors. In total, 85 patients (25%) in the study group were comparable with 252 (75%) patients in the control group regarding demographics (age, gender, body mass index, ASA score), ostomy type and anastomotic technique (all p > 0.05), but not wound contamination class (class III: 5% vs 0%, p < 0.001). Median time to NPWT removal was 4 (IQR 3–5) days. Incisional SSI were observed in 4 patients (4.7%) in the study group and in 27 patients (10.7%) in the control group (p = 0.097). These preliminary results suggest a potential benefit of systematic application of the NPWT device after loop ostomy closure. A randomized controlled study is needed.
A Novel CNN-based Bi-LSTM parallel model with attention mechanism for human activity recognition with noisy data
Authors: Yin Xiaochun , Liu Zengguang , Liu Deyong , Ren Xiaojun 
Published: May 2022

AbstractBoosted by mobile communication technologies, Human Activity Recognition (HAR) based on smartphones has attracted more and more attentions of researchers. One of the main challenges is the classification time and accuracy in processing long-time dependent sequence samples with noisy or missed data. In this paper, a 1-D Convolution Neural Network (CNN)-based bi-directional Long Short-Term Memory (LSTM) parallel model with attention mechanism (ConvBLSTM-PMwA) is proposed. The original features of sensors are segmented into sub-segments by well-designed equal time step sliding window, and fed into 1-D CNN-based bi-directional LSTM parallel layer to accelerate feature extraction with noisy and missed data. The weights of extracted features are redistributed by attention mechanism and integrated into complete features. At last, the final classification results are obtained with the full connection layer. The performance is evaluated on public UCI and WISDM HAR datasets. The results show that the ConvBLSTM-PMwA model performs better than the existing CNN and RNN models in both classification accuracy (96.71%) and computational time complexity (1.1 times faster at least), even if facing HAR data with noise.
Three-dimensional gait analysis of lower extremity gait parameters in Japanese children aged 6 to 12 years
Authors: Ito Tadashi , Noritake Koji , Ito Yuji , Tomita Hidehito , Mizusawa Jun , Sugiura Hiroshi , Matsunaga Naomichi , Ochi Nobuhiko , Sugiura Hideshi 
Published: May 2022

AbstractWe aimed to develop gait standards for gait parameters in school-aged Japanese children and assess age-related differences in gait patterns and parameters. Children aged 6–12 years (n = 424) were recruited from two elementary schools. An instrumented three-dimensional gait analysis system was used to record each child's gait kinematics, kinetics, and spatiotemporal parameters. Participants were subdivided into three age groups (Group A, 6–8 years; Group B, 9–10 years; and Group C, 11–12 years). LMS Chartmaker, version 2.54, was used to create a developmental chart for the gait pattern. The non-normalized step and stride lengths were significantly longer, and the cadence was lower in older children; however, the opposite outcome occurred when analyzing normalized data. Ankle moment differed significantly by age, and the maximum ankle moment was higher in older children than that in younger children. Furthermore, the hip and knee flexion angles during gait and the normalized spatiotemporal parameters of Japanese children aged 6–12 years differed by age and from those of children from other countries. The centile chart of the gait pattern is a useful tool for clinicians to assess developmental changes in the gait pattern and detect gait abnormalities in children.
Three-year outcome following neonatal encephalopathy in a high-survival cohort
Authors: Tsuda Kennosuke , Shibasaki Jun , Isayama Tetsuya , Takeuchi Akihito , Mukai Takeo , Sugiyama Yuichiro , Ioroi Tomoaki , Takahashi Akihito , Yutaka Nanae , Iwata Sachiko , Nabetani Makoto , Iwata Osuke 
Published: May 2022

AbstractThis study investigated the 3-year clinical outcomes in relation to the severity of encephalopathy in high-survival infants who underwent therapeutic hypothermia. This retrospective observational study was conducted in level II/III neonatal intensive care units in Japan. The nationwide cohort included 474 infants registered in the Baby Cooling Registry of Japan between January 2012 and December 2016. Clinical characteristics, mortality rate and severe neurological impairment at age 3 years were evaluated. Of the infants, 48 (10.4%), 291 (63.1%) and 122 (26.5%) had mild, moderate and severe encephalopathy, respectively, upon admission. By age 3, 53 (11.2%) infants died, whereas 110 (26.1%) developed major disabilities. The mild group survived up to age 3. In the moderate group, 13 (4.5%) died and 44 (15.8%) developed major disabilities. In the severe group, 39 (32.0%) died by age 3. Adverse outcomes were observed in 100 (82.0%) infants. Mortality was relatively low in all subgroups, but the incidence of major disabilities was relatively high in the severe group. The relatively low mortality and high morbidity may be due to Japanese social and ethical norms, which rarely encourage the withdrawal of intensive life support. Cultural and ethical backgrounds may need to be considered when assessing the effect of therapeutic interventions.
An innovative antenna array with high inter element isolation for sub-6 GHz 5G MIMO communication systems
Authors: Alibakhshikenari Mohammad , Virdee Bal S. , Benetatos Harry , Ali Esraa Mousa , Soruri Mohammad , Dalarsson Mariana , Naser-Moghadasi Mohammad , See Chan Hwang , Pietrenko-Dabrowska Anna , Koziel Slawomir , Szczepanski Stanislaw , Limiti Ernesto 
Published: May 2022

AbstractA novel technique is shown to improve the isolation between radiators in antenna arrays. The proposed technique suppresses the surface-wave propagation and reduces substrate loss thereby enhancing the overall performance of the array. This is achieved without affecting the antenna’s footprint. The proposed approach is demonstrated on a four-element array for 5G MIMO applications. Each radiating element in the array is constituted from a 3 × 3 matrix of interconnected resonant elements. The technique involves (1) incorporating matching stubs within the resonant elements, (2) framing each of the four-radiating elements inside a dot-wall, and (3) defecting the ground plane with dielectric slots that are aligned under the dot-walls. Results show that with the proposed approach the impedance bandwidth of the array is increased by 58.82% and the improvement in the average isolation between antennas #1&2, #1&3, #1&4 are 8 dB, 14 dB, 16 dB, and 13 dB, respectively. Moreover, improvement in the antenna gain is 4.2% and the total radiation efficiency is 23.53%. These results confirm the efficacy of the technique. The agreement between the simulated and measured results is excellent. Furthermore, the manufacture of the antenna array using the proposed approach is relatively straightforward and cost effective.