bluuebunny/crossref_metadata_2025_split huggingface dataset:
A-119 Adverse Childhood Experiences, Cognitive Functioning, Depression, and Anxiety in Adulthood
Authors: Bing-Canar Hanaan , Khan Humza , Stocks Jane K , Lapitan-Moore Franchezka , Phillips Matthew S , Rauch Andrew , Obolsky Max , Cerny Brian M , Soble Jason R , Jennette Kyle J , Resch Zachary J 
Published: August 2022

Abstract
Objective: Increasing evidence suggests that adverse childhood experiences (ACEs) predict neurocognitive dysfunction, possibly through direct (e.g., brain structure/function changes) and indirect (e.g., increased psychopathology risk) pathways. However, extant studies have focused on young and older adults, with limited understanding as to how ACEs affect cognitive health in mid-adulthood. Therefore, this study compared adults with high vs. low ACE scores on measures of cognitive performance and psychopathology.
Method: This cross-sectional study included 211 adult patients (46.9% female; Mage = 44.9, SD = 17.1; Meducation = 13.8, SD = 3.0) consecutively referred for outpatient neuropsychological evaluation within a large, Midwestern academic medical center. A series one-way analysis of variances (ANOVAs) were conducted to compare high vs. low ACE groups on the Test of Premorbid Functioning (TOPF), Digit Span (DS), Trail Making Test-Part B (TMT-B), Rey Auditory Verbal Learning Test (RAVLT; Immediate and Long Delayed Recall), Beck Depression Inventory-II (BDI-II), and Beck Anxiety Inventory (BAI) scores.
Results: Significant group differences were detected for BDI-II and BAI scores, F(1,159) = 18.38, p.05. Non-significant cognitive measure findings cannot be attributed to group differences in premorbid functioning, as TOPF score also did not significantly differ by ACE group, p &gt; 0.05.
Conclusions: Results of this investigation suggest that greater ACEs increase risk of depression and anxiety, but not neurocognitive dysfunction, in adulthood.
A-127 The Association Between Objectively-Measured Physical Activity and Cognitive Functioning in Middle-Aged and Older People Living with HIV
Authors: Fazeli Pariya , Willig Amanda , Oliveira Vitor , Buford Thomas , Vance David , Burkholder Greer , Crane Heidi , Davey Christine H , Fleming Julia , Webel Allison 
Published: August 2022

Abstract
Objective: Middle-aged and older people living with HIV (PWH) are at higher risk for cognitive impairment and engage in lower levels of physical activity (PA) than seronegative counterparts. Though some studies have examined self-reported PA and cognitive outcomes in PWH, research examining the association between objectively-measured PA and cognitive function in this population is scarce. This cross-sectional study examined the association between accelerometry-measured PA and cognitive functioning in PWH.
Method: In this study of 75 PWH (mean age 55.63) we collected accelerometry-measured PA indices and cognitive functioning from a comprehensive cognitive assessment. Cognitive outcomes included continuous demographically-adjusted T scores for global cognition and individual cognition domains, as well as a binary cognitive impairment variable.
Results: Significant associations were found between PA variables and cognitive domains, including higher bouted (in bouts of ≥10 minutes) light PA minutes per week with better executive function, working memory/attention, and speed of processing performance, adjusted for age and current CD4 count. No significant associations were found between PA variables and the binary cognitive impairment variable, nor were associations found between cognitive functioning variables and a binary variable indicating whether participants met CDC recommendations for PA (i.e., at least 150 minutes per week of moderate-to-vigorous PA).
Conclusions: Findings suggest that although middle-aged and older PWH engage in more light than moderate-to-vigorous PA, light PA may be beneficial to cognition. Longitudinal studies are needed to understand PA dose–response associations with cognitive trajectories, cognitive domain specificity of PA effects, and underlying neural mechanisms of PA.
A-128 Treatment Preferences for Cancer-Related Cognitive Impairment in Patients with Primary Brain Tumor
Authors: Braun Sarah E , Lanoye Autumn , Reid Morgan , Fox Amber , Aslanzadeh Farah , Kleva Chris , Loughan Ashlee 
Published: August 2022

Abstract
Objective: Patients with primary brain tumors (PwPBT) experience negative cognitive sequalae (cancer-related cognitive impairment; CRCI) as a result of tumor burden, surgical intervention, radiotherapy, and chemotherapy. Research investigating CRCI treatments for PwPBT remains nascent. Most of the previous investigations have applied interventions developed for and tested in other medical populations to PwPBT, leaving gaps in our understanding of what might best serve the specific needs of PwPBT. Thus, the present study examined sources of cancer-related distress and preferences for interventions to address CRCI in PwPBT.
Methods: As part of institutional quality improvement, PwPBT rated specific symptoms of cancer-related distress (from “not at all” to “very much” bothered) as well as preferences for specific interventions to address or cope with CRCI (from “not at all” to “very” interested). Patients also self-reported demographics and medical characteristics. Descriptive statistics characterized sources of distress and treatment preferences.
Results: PwPBT (N = 41, age 45.1 + 13.2, 52.5% male, 87.5% White) completed the questionnaire. Fatigue (54%) and cognitive changes (53%) were rated as the most distressing symptoms following brain tumor diagnosis. Cognitive rehabilitation (42%) and mindful movement (42%) were the most preferred interventions for management of CRCI; followed by psychotherapy (37%), mindfulness meditation (30%), and medication (20%).
Discussion: As expected, cognitive changes were a highly-rated source of distress for PwPBT, second only to fatigue. Both formal cognitive rehabilitation and mindful movement, or gentle exercise like yoga, were the most preferred interventions for management of CRCI. Importantly, these interventions may dually address fatigue symptoms for PwPBT. These data can inform future intervention development within neuro-oncology.
A-129 Epilepsy, Attention-Deficit/Hyperactivity Disorder (ADHD), and the Role of Internalization: A Twin Case Study
Authors: Miranda Melissa G , Golden Charles J , Marrakchi Dina , Neustater Jessica 
Published: August 2022

Abstract
Objective: Children with a diagnosis of Attention-Deficit/Hyperactivity Disorder (ADHD) comorbid with epilepsy have a significantly poorer quality of life and predominantly inattentive presentation, compared to children who solely have ADHD or epilepsy (Ozalp et al., 2017). The current case study considers a neuropsychological evaluation of ten-year-old twins, both with a comorbid diagnosis of epilepsy and ADHD, and how emotional functioning and internalization of diagnoses contributes to their quality of life.
Method: At age six, both children were diagnosed with epilepsy, and exhibited tonic–clonic seizures concurrently. At age nine, both children were diagnosed with ADHD, predominantly inattentive type. A neuropsychological evaluation was conducted for each child to discover the unique strengths and deficits present, despite a congruent previous diagnosis. The evaluation included a battery of intelligence, memory, achievement, attention, executive, and emotional functioning (objective and projective) tests.
Results: Results confirmed ADHD, inattentive type in both children. They displayed strengths in verbal abilities, and evidenced deficits in executive functioning, fine motor skills, and attention. However, one twin consistently performed better in most domains. Differences were found in emotional functioning, as one twin reported clinically significant scores regarding his perception of cognitive impairment, feelings of depression, and psychological discomfort.
Conclusions: The addition of twin studies to literature is crucial, especially considering differences in the manifestation of comorbid diagnoses. Clinicians must consider the internalization of diagnoses in children, as emotion has a substantial influence on their functioning and cognitive processes. The study further emphasizes the need for emotional evaluation as a standard component of neuropsychological batteries.
A-132 Reward Learning Bias and Risky Decision Making Moderation of ADHD Symptom Associations with Emotion Dysregulation
Authors: Baker Essence , Yaroslavsky Ilya 
Published: August 2022

Abstract
Objective: Risky decision-making that prioritizes immediate gains over high potential losses (risky decision-making) and a heightened responsiveness to reward-based learning (reward bias) reflect individual differences tied to emotion dysregulation (ED) and Attention Deficit Hyperactivity Disorder (ADHD). However, risky decision-making and reward bias may also potentiate the association between ADHD and ED, which we hypothesize.
Method: University students (N = 57) completed measures of inattention, motor-, and verbal-hyperactivity (Adult ADHD Self-Report Scale) and goal-, impulsivity-, and emotion regulation strategy implementation-deficits (Difficulties in Emotion Regulation Scale). Risky decision-making and reward bias were measured via the Iowa Gambling Task and the Probalistic Reward Learning task using E-Prime v. 2.0.
Results: Inattention symptoms positively correlated with the three DERS subscales (rs = 0.28–0.44,ps &lt; 0.03), reduced reward bias (r = −0.30,p = 0.03), and hyperactivity symptoms (rs = 0.29–0.31,ps &lt; 0.03); no other association involving ADHD indices reached significance. MANOVAs revealed significant three-way interactions between risky decision-making, reward bias and motoric hyperactivity (F = 3.42,p = 0.025) and inattention at a trend level (F = 2.73,p = 0.055). Follow-up ANOVAs (Fs = 6.00–8.45, ps &lt; 0.02) and post-hoc probes revealed that patterns of high reward bias and low risky decision making were consistently linked with ED with increasing motor hyperactivity and inattention symptoms, as was the pattern of low reward bias and high risky decision-making. Conversely, a high reward bias combined with slow risky decision-making reduced the tie between those two ADHD symptoms and ED.
Conclusion: Results suggest a nuanced interplay between decision-making, reward bias, and ADHD symptoms in relation to ED, which is consistent with others finding ADHD to be a heterogenous disorder. Clinical implications of the observed individual-differences patterns warrant further investigation.
A-137 Cortical Vision Impairment: A Case Study of Associated Neurodevelopmental Disorders and Neuropsychological Findings
Authors: Colley Julia , Culotta Vincent P , Culotta Anna E 
Published: August 2022

Abstract
Objective: Cortical Visual Impairment (CVI) is characterized by a decreased visual response, related to a neurological lesion. It is the most common cause of permanent visual impairment in children. CVI is not attributed to the functioning of the eyes, but instead to visual processing centers and pathways. Deficits due to CVI may lead to impairment in cognitive, learning, and social domains. The objective of the case study is to examine neuropsychological findings of a child with CVI.
Method: The subject was a 10-year, 2-month old male with a history of seizure activity. Based on decreased corpus callosum and PVL, a diagnosis of CVI was made. He evidenced significant visual latencies and difficulties with visual novelty. Continuing behavioral and academic concerns resulted in a referral for evaluation.
Results: Assessment revealed extremely low cognitive ability. Relative strengths were evident in nonverbal skills. Academic skills fell at the pre-K to early K level. Neurocognitive functions ranged from the low to the very-low range with relative strengths in rapid naming, symbol recognition, semantic memory, and social intent. Findings on the SRS-2 and the ADOS-2 revealed difficulties with social awareness and communication but were not consistent with an ASD.
Conclusions: CVI is a prevalent cause of visual impairment in children. Children often display multiple developmental disorders and features of autism and low cognitive ability are not uncommon. Disentangling the role of CVI in early cognitive, social, and adaptive development remains an important area for research. Assessment to identify strengths and weakness to facilitate social, academic and adaptive development is necessary.
A-138 Investigation of Potential Involvement of The Adrenal Cortex In The Pathogenesis of Autism In Prepubertal Male Jordanian Children
Authors: Alhader Abdelfattah , Kana'an Saddam F , Nazzal Mohammad 
Published: August 2022

Abstract
Objective: The investigation of adrenal steroids and testosterone levels in male autistic children will, undoubtedly, help to elucidate the pathogenetic implication of these hormones in the development of autism and their role as risk factors. The objective of this case-control study is to explore the potential involvement of adrenal steroids in the pathogenesis of autism.
Method: Serum levels of total testosterone (TT), dehydroepiandrosterone (DHEA) and sex-hormone binding globulin (SHBG) were measured in 32 Jordanian autistic male patients and in 32 healthy age-matched children. Independent t-test was used to investigate statistical significance in study groups with a (p) value of less than 0.05 was considered significant. Preliminary univariate logistic regression was used to assess which of the measured lab parameters should be included in the final regression models. Multivariable logistic regression (backward stepwise selection) was used in autism risk prediction.
Results: TT had a positive strong correlation with DHEA (r=+62, p≤0.001), suggesting an adrenal source of the elevated androgens. The Likelihood of developing autism was increased by 1.03 times for an increase in one ng/dl of DHEA, by 0.92 times for an increase by one nmol/l of SHBG and by only 0.04 times for an increase in one mIU/ml of FSH.
Conclusions: The demonstrated positive strong correlation between TT and DHEA in pre-pubertal male autistic children further substantiates the potential involvement of the adrenal cortex in the pathogenesis of autism. Further studies are needed to elucidate their role in the prediction and development of autism.
A-140 Parental Satisfaction with Neuropsychological Evaluations and their Pursuit of Recommendations
Authors: Hanna Amira , Tam Helen , DeLuco Tara , Montalto Daniela 
Published: August 2022

Abstract
Objective: Parent’s overall satisfaction with neuropsychological evaluations has been consistently linked with implementation of recommendations and follow-up care. The aim of this study was to establish stability of satisfaction over time, as well as to confirm findings that parents were more likely to pursue school-based as compared to behavioral health recommendations.
Method: Study participants (ages 4-17, 63% white, 83% non-Hispanic) were recruited from an outpatient clinic, shortly after completing a neuropsychological evaluation. Parent satisfaction data were collected at 3-weeks (T1 n=49) and 6-months (T2 n=30) following evaluation completion.
Results: Parent perceived usefulness ratings were largely consistent between T1 and T2, with 96.4% to 98.1% of overall usefulness ratings falling in the useful/very useful categories. Study participants who completed both the 3-week and 6-month surveys did not differ across demographic variables. Participants who completed both T1 and T2 surveys reported higher initial satisfaction ratings as compared to those who only completed T1 (T1 mean=4.92, SD=0.28, T2 mean=4.83, SD=0.39; t(46)=-0.97, p=05). Additionally, participants who completed both surveys were somewhat more willing to pursue recommendations including, school placement (55.6% vs. 44.4%), in-classroom (53.8% vs. 46.2%), and testing accommodations (62.5% vs. 37.55). Consistent with recent findings, parents were generally more likely to pursue school-based (95.7%) as compared to behavioral health recommendations (84.4%).
Conclusion(s): Parents in this sample were largely satisfied with the evaluation process, with increased satisfaction predicting follow-up care and a higher likelihood of pursuing recommendations. Additionally, data independently corroborated that parents are more likely to pursue school-based compared to behavioral health recommendations.
A-149 Being Othered: Associations between Discrimination and Perceived Stroke Risk in Biracial persons
Authors: Abbas Maleeha T , Stevens Domonique , Garcia James J 
Published: August 2022

Abstract
Objective: Separate lines of research show that biracial people experience unique racial microaggressions (Johnston & Nadal, 2010), while also having elevated stroke risk (Kissela et al., 2021). However, research is lacking on the exact quantitative relationship between discrimination and perceived stroke risk in biracial individuals.
Method: Biracial people (N = 421) completed the Brief Perceived Ethnic Discrimination Questionnaire (PEDQ), the Intersectional Discrimination Index (InDI), and the Perceived Stroke Risk subscale of the ABCD Risk Questionnaire. Depression was measured via the Patient Health Questionnaire-9 (PHQ-9) as a covariate. One hierarchical linear regression was used, with depression in block 1, brief PEDQ in block 2, and the subscales of the InDI in block 3 to predict perceived stroke risk.
Results: All participants were Biracial, ranging from 18-76 of age (M = 34.9, SD = 10.4). The sample was 62% non-Hispanic Biracial and 38% Hispanic Biracial. For block 1, depression was significantly and positively associated with stroke risk (β= .51, p &lt; .001). In block 2, the Threat Harassment subscale of the PEDQ was positively and significantly associated with stroke risk (β= .42, p = .002). In block 3, anticipated (β= .168, p &lt;.001) and major intersectional discrimination (β = .120, p = .039) were positively and significantly associated with perceived stroke risk.
Discussion: Findings suggest race-based and intersectional discrimination are associated with perceived stroke risk among Biracial persons. Implications for Clinical Neuropsychology practice with Biracial people who have elevated stroke risk are discussed.
A-159 Neurocognitive Performance in Post-Acute Sequelae of COVID-19 (PASC)
Authors: Lokken Kristine , Greenfield Melissa J , Robinson Jamie Hansel , Shah Udit Vipul , Lazar Ronald M , Kennedy Richard , Martin Roy C , Gerstenecker Kristen Triebel , Gerstenecker Adam , Wheeler Pariya Fazeli , Agnihotri Shruti P , Vance David E 
Published: August 2022

Abstract
Objective: Describe cognitive function in patients seeking treatment for Post-Acute Sequelae of COVID-19 (PASC).
Method: Ninety-two patients underwent neuropsychological evaluation secondary to reported “brain fog” following COVID-19 infection. Patients were referred from the University of Alabama at Birmingham (UAB) Post-COVID Treatment Program. Patients were on average 49 years of age (range: 18-74), female (77%), and White/Caucasian (73%)/Black/AA (25%), with 15.49 years of education (SD = 2.43).
Results: Overall, many patients demonstrated mild impairment on a brief global cognitive screener (MoCA; M = 24.78, SD = 3.46). On specific tasks of cognitive abilities, processing speed was variable; ranging from low average (Oral TMT Part A; M = 88.31, SD = 28.78) to below average (Oral SDMT; M = 72.80, SD = 20.37). Memory for immediate recall was low average (CVLT3-Brief Form (BF) Trials 1-4, M = 88.01, SD = 17.11), while delayed recall was average (CVLT3-BF, M = 94.17, SD = 19.11). Performances on measures of attention/working memory (WAIS-IV Digit Span; M = 96.75, SD = 12.54), executive functioning (Oral TMT Part B; M = 92.71, SD = 28.48), language (COWAT; M = 92.03, SD = 14.19) and visuospatial abilities (RBANS Figure Copy M = 104.04, SD = 16.08) were intact. Performance on embedded validity measures was also intact (RDS [95% valid]; CVLT-3 FC [93% valid]).
Conclusion: Overall, patients with “brain fog” following COVID-19 infection experience difficulties in specific domains of cognitive functioning. Further investigation of neuropsychological profiles associated with PASC is warranted to inform diagnosis, neurocognitive trajectory, and treatment planning.
A-162 Neuropsychological Functioning in Migraine: A Meta-Analysis
Authors: Pizer Jasmin H , Aita Stephen L , Myers Melissa A , Hawley Nanako A , Ikonomou Vasilios C , Brasil Kyle M , Hernandez Katherine A , Pettway Erika C , Hill Benjamin D 
Published: August 2022

Abstract
Objective: Migraine refers to recurrent, unilateral headache attacks, lasting 4-72 hours, that have a pulsating quality. A meta-analysis was conducted comparing cognition on clinical measures between individuals with migraine and healthy controls.
Data Selection: We searched the University of South Alabama Libraries’ OneSearch and PubMed using a uniform search-strategy to locate original research comparing cognition between migraine and control samples. Analyses were modeled under random effects. Hedge’s g was used as a bias-corrected estimate of effect size. We assessed between-study heterogeneity using Cochran’s Q and I2.
Data Synthesis: The initial search interval spanned inception–May 2021 and yielded 6692 results. Fifty-two studies were analyzed (migraine n=5324, control n=16540). Meta-analysis showed a significant combined effect size of migraine across all studies (g=-0.37, p&lt;.001), with high heterogeneity (Q=329.84, p&lt;.001, I2=84.54). Trim-and-fill procedure estimated 0 studies to be missing due to publication bias (adjusted g=-0.37, Q=329.84). Within-domain effects of migraine were: Executive Functioning=-0.40, Global Cognition/Orientation=-0.20, Language=-0.30, Learning/Memory=-0.24, Motor=-0.09, Processing Speed=-0.42, Screener=-0.50, Simple/Complex Attention=-0.35, and Visuospatial/Construction=-0.36. Heterogeneity was moderate to high within domains. Meta-regressions indicated education and disease duration were not related to effect sizes. Age and gender were related to effect sizes such that studies with older and higher percentage of female clinical participants yielded greater (negative) differences.
Conclusions: Individuals with migraine consistently demonstrated lower performances on neuropsychological tests compared to controls. Effect sizes were generally small in strength, with largest effects in Executive Functioning, Processing Speed, and Screeners. This quantitative summary indicates that, through use of neuropsychological tests, individuals with migraine experience difficulties in multiple aspects of cognition.