bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the Application of GMP and SSOP in Efforts to Improve Food Safety in SMES Processed Shredded Milkfish Bunda Juminah Food in Cipadung Kidul Village, Bandung City
Authors: Kurniawan Ervira Octaviola , Pratama Rusky Intan , Rosidah . , Rostini Iis 
Published: August 2022

This study aims to analyze the quality control of food safety with the Good Manufacturing Practices (GMP) and Sanitation Standard Operating Procedures (SSOP) systems in Small and Medium Enterprises (SMEs) processed from milkfish shredded Bunda Juminah Food and compare it with the Regulation of the Minister of Maritime Affairs and Fisheries of the Republic of Indonesia Number 17/PERMEN-KP/ 2019 so that it can provide recommendations for improvement in efforts to improve food safety. This research uses a case study method, the discussion is descriptive with a qualitative approach. The parameters observed in this research include the Total Plate Count (TPC) test, water content test, and protein content test. The data obtained from this research were analyzed descriptively comparatively. The results of the research show that the application of GMP and SSOP in Small and Medium Enterprises (SMEs) Bunda Juminah Food is not in accordance with the standards set in the aspect of raw material selection. The implementation of SSOP in Bunda Juminah Food UKM is also not in accordance with the standards set in the aspect of preventing cross contamination, employee health and hygiene conditions, and controlling nuisance animals. Based on the results of the Total Plate Count (TPC) test, water content and protein content tests, Bunda Juminah Food's shredded milkfish products meet Indonesian National Standards.
Clinical Characteristics and Etiology of Chronic Liver Disease among Egyptian Patients in Nile Delta: A Clinical Study
Authors: Abd-Elrazek Mortada M. , El-Gharabawy Nashwa M. , Atlam Samir A. , Gabr Mamdouh A. 
Published: August 2022

Background: Chronic liver disease (CLD) is an extremely common clinical condition that causes significant morbidity and mortality and was responsible for 1.3 million deaths worldwide. There had been a 46% increase in CLD mortality in the world between 1980 and 2013 and most of this increase has been reported in low-income countries in Asia and Africa including Egypt. These countries are experiencing a demographic and epidemiologic transition in disease burden and Egypt is one of the epicenters of this change. Previously, CLD in Egypt was traditionally attributed to schistosomiasis mainly in the region of the Nile Delta until the mid-1980s.
Aims: To capture the modes of clinical presentation and at which stage CLD patients seek clinical care, as well as the dramatic change in the etiological profile of CLD in this area of the Nile Delta
Methods: 1013 newly diagnosed CLD patients were selected and identified from the Tanta Liver Center (TLC) across the middle of the Nile Delta. After informed or written consent, all consecutive patients (18 years and above) referred to TLC with suspected or overt chronic liver disease were subjected to full history taking, clinical examination searching for stigmata of chronic liver disease, and laboratory studies including urine, blood sugar, liver biochemical tests (bilirubin, ALT, AST& serum albumin), prothrombin, viral markers (HCV Ab & HBS Ag) and AFP. Imaging studies including the abdominal US for all patients and triphasic CT and liver biopsy in selected patients.
Results: About 50% of our CLD patients present at a relatively advanced stage of decompensated cirrhosis (ascites in 39.2%, bleeding in 22.8%, and HCC in 9.3%).
CLD patients of schistosomal etiology presented mainly with manifestations of portal hypertension (splenomegaly, UGI Bleed & thrombocytopenia) that was significantly higher than the other 2 groups.
The vast majority of our CLD patients (83.5%) have viral etiology, while only 11.1% have schistosomal etiology and the remaining 5.4% have non-identified etiology.
Conclusion: based on the results of the present study, it is evident that HCV had replaced schistosomiasis as the predominant cause of CLD in Egypt particularly in the region of the Nile Delta. The late presentation of a good percentage of our CLD patients raises the importance of screening programs for CLD in this endemic area of the Nile Delta.
Outcome of Germ Cell Tumors in Children after Surgical Management; A Longitudinal Study
Authors: Sumaira . , Qureshi Mumtaz Ahmed , Perveen Shazia , Mahtam Ishrat , Imam Uzma , Chohan Muhammad Nadeem 
Published: August 2022

Aim: To assess the outcome of germ cell tumors in children after surgical management.
Study Design: A longitudinal study.
Place and duration: Pediatric surgery and oncology department of the national institute of child health Karachi from January 2017 to December 2018.
Methodology: A total of 79 children between the ages of 0 to 12 years were included in the study. Baseline, ultrasound, CT scan, tumor markers, and biopsy for tissue diagnosis were done. After surgical excision, they were followed up for 12 months with tumor markers, ultrasound and CT Scans for any recurrence. We just observed patients with mature teratoma and did surveillance for immature variety. The rest of the subtypes received JEB chemotherapy (carboplatin, etoposide, and bleomycin) as per UK-based chemotherapy protocol according to their disease stage.
Results: Most common age of presentation was < 1 month old. The antenatal diagnosis was made in 2 (2.5%) children. Sacrococcygeal region 54 (68.3%) was the most commonly involved region followed by gonads in 17 (21.5%) cases. According to histology mature teratoma was present in 32 (40.5%) children. Complete resection was done in 52 (65.8%) children. Recurrence occurred in one child and 3 children expired.
Conclusion: In the current study, the general outcome was good in terms of complete excision in most of the patients. Worst outcome noted in yolk sac tumor. There was a minimal recurrence rate.
INSTINTO, SENTIMENTO E MELANCOLIA
Authors: Souza Lorenna de Araújo 
Published: August 2022

O presente artigo apresenta um estudo comparativo sobre as significações da morte no romance Tereza Batista Cansada de Guerra do escritor regionalista Jorge Amado, examinando-as a partir dos pensamentos psicanalíticos de Sigmund Freud. Para explorar os diferentes significados, fez-se necessário analisar a morte e as atitudes da protagonista, Tereza Batista, em torno desse fenômeno com base nos conceitos freudianos estudados em seus ensaios O Ego e o Id, Luto e Melancolia e Além do princípio do prazer. Podemos compreender e analisar por meio do funcionamento da psiquê humana como a personagem principal, Tereza Batista, comportava-se diante da morte, que é revelada no romance através do medo, do luto, da melancolia, dos instintos e dos conflitos do Eu, aqui também analisados e explicados com base em conceitos psíquicos.
Palavras-chave: Morte; Literatura; Psicanálise; Jorge Amado
Cardiomyopathy correlates to nerve damage in p.A117Slate‐onset transthyretin amyloid polyneuropathy
Authors: Lin Yen‐Hung , Hsueh Hsueh‐Wen , Su Mao‐Yuan , Cheng Mei‐Fang , Chiang Ming‐Chang , Juang Jyh‐Ming Jimmy , Kao Yi‐Hui , Chang Kai‐Chieh , Feng Fang‐Ping , Hsieh Sung‐Tsang , Chao Chi‐Chao 
Published: August 2022

AbstractObjectiveLate‐onset hereditary transthyretin amyloidosis with polyneuropathy (ATTRv‐PN) is often associated with heart involvement. Recent advances in cardiac imaging allow the detection of cardiac amyloidosis. This study aimed to explore cardiomyopathy by cardiac imaging and its clinical correlates with polyneuropathy in late‐onset ATTRv‐PN.MethodsPolyneuropathy was assessed by intraepidermal nerve fiber (IENF) density, nerve conduction study (NCS), autonomic function tests, quantitative sensory testing, and clinical questionnaires. Cardiomyopathy was evaluated by echocardiography,99mTc‐pyrophosphate (PYP) single‐photon emission computed tomography (SPECT) imaging, cardiac magnetic resonance imaging (CMR), and serum Pro‐B‐type natriuretic peptide. Healthy controls and patients with Brugada syndrome were enrolled for comparison of CMR.ResultsFifty late‐onset ATTRv‐PN patients (38 men, 46 with p. A117S mutation), aged 63.7 ± 5.5 years, of polyneuropathy disability stage 1–4 were enrolled. All patients presented polyneuropathy in NCS, and 74.5% of patients had reduced IENF density in distal legs. All patients showed significant radiotracer uptake in the heart on99mTc‐PYP SPECT imaging, and 87.8% of patients had abnormally increased left ventricular (LV) septum thickness on echocardiography. CMR showed longer myocardial native T1, larger extracellular volume, greater LV mass index, and higher LV mass to end‐diastolic volume ratio in ATTRv‐PN patients than healthy controls and patients with Brugada syndrome. These CMR parameters were associated with skin denervation, absent sympathetic skin responses, elevated thermal thresholds, worsened NCS profiles, and functional deficits of polyneuropathy.InterpretationLate‐onset ATTRv‐PN coexisted with cardiomyopathy regardless of the clinical severity of polyneuropathy. The cardiac amyloid burden revealed by CMR was correlated with pathophysiology and clinical disability of nerve degeneration.
Low‐Temperature Plasma‐Assisted Growth of Large‐Area MoS2 for Transparent Phototransistors
Authors: Bala Arindam , Liu Na , Sen Anamika , Cho Yongin , Pujar Pavan , So Byungjun , Kim Sunkook 
Published: August 2022

AbstractMoS2‐based transparent electronics can revolutionize the state‐of‐the‐art display technology. The low‐temperature synthesis of MoS2 below the softening temperature of inexpensive glasses is an essential requirement, although it has remained a long persisting challenge. In this study, plasma‐enhanced chemical vapor deposition is utilized to grow large‐area MoS2 on a regular microscopic glass (area ≈27 cm2). To benefit from uniform MoS2, 7 × 7 arrays of top‐gated transparent (≈93% transparent at 550 nm) thin film transistors (TFTs) with Al2O3 dielectric that can operate between −15 and 15 V are fabricated. Additionally, the performance of TFTs is assessed under irradiation of visible light and estimated static performance parameters, such as photoresponsivity is found to be 27 A W−1 (at λ = 405 nm and an incident power density of 0.42 mW cm−2). The stable and uniform photoresponse of transparent MoS2 TFTs can facilitate the fabrication of transparent image sensors in the field of optoelectronics.
Tuning Molecular Chromophores of Isoreticular Covalent Organic Frameworks for Visible Light‐Induced Hydrogen Generation
Authors: Li Wen , Ding Xu , Yu Baoqiu , Wang Hailong , Gao Zhuo , Wang Xinxin , Liu Xiaolin , Wang Kang , Jiang Jianzhuang 
Published: August 2022

AbstractThe functions of covalent organic frameworks (COFs) can be tailored by covalently reticulating advanced molecular modules into well‐defined porous ordered materials. Herein, four COFs, USTB‐7–USTB‐10, are prepared from the solvothermal reaction of photoactive tetraaldehydes, 5,5″‐(benzo[c]‐[1,2,5]thiadiazole‐4,7‐diyl)diisophthalaldehyde and 5,5″‐(naphtho[2,3‐c][1,2,5]thiadiazole‐4,9‐diyl)diisophthalaldehyde, with p‐phenylenediamine and benzidine, respectively. Comprehensive studies of powder X‐ray diffraction, theoretical simulation, and pore size distribution disclose their isoreticular 2D dual porous structures. In contrast to benzo[c][1,2,5]thiadiazole‐based chromophore, employment of naphtho[2,3‐c][1,2,5]thiadiazole‐based tetraaldehyde enables enlarged conjugation systems for USTB‐9 and USTB‐10, rather than USTB‐7 and USTB‐8. This, in combination with the longer benzidine unit, endows USTB‐10 with a porous structure with bigger pore size than that of USTB‐9, resulting in the highest photocatalytic hydrogen production rate of 21.8 mmol g−1 h−1 with the help of a Pt cocatalyst. Experimental and theoretical studies reveal the outstanding photocatalytic activity for USTB‐10 among the four COFs associated with the narrowed bandgap and increased charge‐carrier separation efficiency.
The impact of winter warming and more frequent icing events on reindeer herder occupational safety, health, and wellbeing
Authors: Ocobock Cara , Turunen Minna , Soppela Päivi , Rasmus Sirpa 
Published: August 2022

AbstractBackgroundNorthern Finland, like the rest of the Arctic, has experienced increases in mean annual temperature, the number of winter rains, the number of thaw–freeze days, the number of extremely warm weather events, and a shortened snow season. These changes have produced numerous problems for reindeer herders whose livelihoods rely on a healthy ecosystem with predictable weather patterns.MethodsWe performed a scoping literature review to assess how climate change induced extreme weather has negatively impacted reindeer herding as well as the health and wellbeing of reindeer herders.ResultsLate snow cover negatively impacts reindeer herding through a more widely dispersed herd that increases the work to gather reindeer, leads to reduced calf weight, and results in less meat for sale. This increased labor, especially in extreme cold conditions, can also negatively impact reindeer herder health. Icing due to thaw–freeze and rain‐on‐snow events makes it impossible for reindeer to dig through the snow to access lichens, increasing the need for reindeer herders to keep the herd in winter enclosures and provide supplemental feed.ConclusionClimate change induced weather events such as late snow cover and icing increase reindeer herder efforts and expenses, put their livelihood at risk, and put their health at risk.
Neurovascular complications in adults with Neurofibromatosis type 1: A national referral center experience
Authors: Sheerin Una‐Marie , Holmes Paul ,   The London NF1 Research Group, Childs Lucy , Roy Amit , Ferner Rosalie E. 
Published: August 2022

AbstractNeurofibromatosis type 1 (NF1) is associated with a range of vascular abnormalities. To assess the frequency, clinical and imaging spectrum of vascular complications in an adult cohort of NF1 patients, we reviewed 2068 adult NF1 patient records seen in our service between 2009 and 2019, to determine presence of vascular abnormalities, age at detection, associated symptoms and management. A literature review of the range of vascular abnormalities associated with NF1 was also undertaken. 1234 patients had magnetic resonance imaging cranial imaging. The frequency of vascular abnormalities associated with NF1 patients who had cranial imaging in this cohort was 3.5% (n = 43), the majority (n = 26, 60%) were symptomatic. Stroke and cerebral arterial stenosis were the commonest vascular complication. Eight patients (0.65%) had more than one type of vascular abnormality. One death due to a vascular complication was identified and significant morbidity resulted from other complications. We conclude that clinicians caring for patients with NF1 need to be cognizant that rapid onset of new neurological symptoms or signs may be the result of a vascular complication of NF1 and require urgent investigation and management, ideally within specialist teams who have experience of managing vascular complications of NF1.
Appositional long bone growth: Implications for measuring cross‐sectional geometry
Authors: Kurki Helen K. , Holland Sydney , MacKinnon Marla , Cowgill Libby , Osipov Benjamin , Harrington Lesley 
Published: August 2022

AbstractObjectivesAs growth at the periosteal and endosteal surfaces varies with age, cross‐sectional geometric (CSG) properties derived from periosteal (“solid”) contours may not produce comparable results to those from endosteal and periosteal contours (“true”), contrary to findings from adults. Error in CSG properties derived from the “solid” sections is compared with “true” sections in a sample of archeologically derived skeletons with estimated dental ages ranging from 1.5 months to 23.5 years.Materials and MethodsCross sections were extracted from 3D surface models, and endosteal contours were located from biplanar radiographs for 56 femora and 59 humeri. Polar second moment of area (J), cross‐sectional shape (Imax/Imin), and polar section modulus (Zp) were calculated from solid and true sections. Relationships between solid and true properties were examined with least squares regression. Multiple regression examined the effect of age and % cortical area on solid section CSG error.ResultsWhile correlations were high (R2 = 0.72–0.99, all p < 0.001), the results indicate that solid CSG properties are not within an acceptable error range (%SEE of ≤8.0, and %PE of ≤5.0) of true CSG. Error was most affected by %CA, while estimated age was not correlated with %CA, %PE, or percent difference of true‐solid CSG.DiscussionPeriosteal contours alone should not be used to calculate CSG properties from individuals during the period of growth and development. Variation in bone growth and/or adaptive responses independent of age may account for the inconsistent age effects.
Genome‐wide profiling of circulatory microRNAs associated with cognition and dementia
Authors: Yaqub Amber , Mens Michelle M.J. , Klap Jaco M. , Weverling Gerrit Jan , Klatser Paul , Brakenhoff Just P.J. , Roshchupkin Gennady V. , Ikram Mohammad Kamran , Ghanbari Mohsen , Ikram Mohammad Arfan 
Published: August 2022

AbstractIntroductionMicroRNAs (miRNAs) are post‐transcriptional regulators of gene expression. Their role in the pathophysiology of dementia and potential as biomarkers remains undetermined.MethodsWe conducted a single‐ (one‐by‐one) and multi‐marker (joint) analysis to identify well‐expressed circulating miRNAs in plasma (total = 591) associated with general cognition and incident dementia, for 1615 participants of the population‐based Rotterdam Study.ResultsDuring single‐marker analysis, 47 miRNAs were nominally (P ≤ .05) associated with cognition and 18 miRNAs were nominally associated with incident dementia, after adjustment for potential confounders. Three miRNAs were common between cognition and dementia (miR‐4539, miR‐372‐3p, and miR‐566), with multi‐marker analysis revealing another common miRNA (miR‐7106‐5p). In silico analysis of these four common miRNAs led to several putative target genes expressed in the brain, highlighting the mitogen‐activated protein kinase signaling pathway.DiscussionWe provide population‐based evidence on the relationship between circulatory miRNAs with cognition and dementia, including four common miRNAs that may elucidate downstream mechanisms.HIGHLIGHTSMicroRNAs (miRNAs) are involved in the (dys)function of the central nervous system.Four circulating miRNAs in plasma are associated with cognition and incident dementia.Several predicted target genes of these four miRNAs are expressed in the brain.These four miRNAs may be linked to pathways underlying dementia.Although miRNAs are promising biomarkers, experimental validation remains essential.
Hydrolytically Stable Ionic Fluorogels for High‐Performance Remediation of Per‐ and Polyfluoroalkyl Substances (PFAS) from Natural Water
Authors: Manning Irene M. , Guan Pin Chew Nick , Macdonald Haley P. , Miller Kelsey E. , Strynar Mark J. , Coronell Orlando , Leibfarth Frank A. 
Published: August 2022

AbstractPFAS are known bioaccumulative and persistent chemicals which pollute natural waters globally. There exists a lack of granular sorbents to efficiently remove both legacy and emerging PFAS at environmentally relevant concentrations. Herein, we report a class of polymer networks with a synergistic combination of ionic and fluorous components that serve as granular materials for the removal of anionic PFAS from water. A library of Ionic Fluorogels (IFs) with systematic variation in charge density and polymer network architecture was synthesized from hydrolytically stable fluorous building blocks. The IFs were demonstrated as effective sorbents for the removal of 21 legacy and emerging PFAS from a natural water and were regenerable over multiple cycles of reuse. Comparison of one IF to a commercial ion exchange resin in mini‐rapid small‐scale column tests demonstrated superior performance for the removal of short‐chain PFAS from natural water under operationally relevant conditions.
Spontaneous Decomposition of an Extraordinarily Twisted and Trans‐Bent Fully‐Phosphanyl‐Substituted Digermene to an Unusual GeI Cluster
Authors: Izod Keith , Liu Mo , Evans Peter , Wills Corinne , Dixon Casey M. , Waddell Paul G. , Probert Michael R. 
Published: August 2022

AbstractDitetrelenes R2E=ER2 (E=Si, Ge, Sn, Pb) substituted by multiple N/P/O/S‐donor groups are extremely rare due to their propensity to disaggregate into their tetrylene monomers R2E. We report the synthesis of the first fully phosphanyl‐substituted digermene {(Mes)2P}2Ge=Ge{P(Mes)2}2 (3, Mes=2,4,6‐Me3C6H2), which adopts a highly unusual structure in the solid state, that is both strongly trans‐bent and highly twisted. Variable‐temperature 31P{1H} NMR spectroscopy suggests that 3 persists in solution, but is subject to a dynamic equilibrium between two conformations, which have different geometries about the Ge=Ge bond (twisted/non‐twisted) due to a difference in the nature of their π‐stacking interactions. Compound 3 undergoes unprecedented, spontaneous decomposition in solution to give a unique GeI cluster {(Mes)2P}4Ge4⋅5 CyMe (7).
Regioselective Transition‐Metal‐Free C(sp2)−H Borylation: A Subject of Practical and Ongoing Interest in Synthetic Organic Chemistry
Authors: Rej Supriya , Chatani Naoto 
Published: August 2022

AbstractConsiderable advances have been made in the area of C−H functionalization in the last few decades. A number of approaches including both directed and nondirected strategies have been developed thus far. Among the various C−H functionalizations, C−H borylation is of special interest due to the wide applications of organoboron compounds. In this regard, various transition‐metal‐catalyzed regioselective strategies have been developed. However, the major concern regarding metal‐catalyzed C−H borylation procedures is the requirement of a precious metal as well as the contamination by metal precursors in the desired products, which limit the application of this process in large‐scale synthesis. Therefore, recent trends have involved the use of transition‐metal‐free systems. We summarize recent developments in transition‐metal‐free regioselective C−H borylation. We believe that this Review will help to increase interest in this field and stimulate further progress.
Self‐Propelled Initiative Collision at Microelectrodes with Vertically Mobile Micromotors
Authors: Guo Ziyi , Wu Yanfang , Xie Zhouzun , Shao Junming , Liu. Jian , Yao Yin , Wang Joseph , Shen Yansong , Gooding J. Justin , Liang Kang 
Published: August 2022

AbstractImpact experiments enable single particle analysis for many applications. However, the effect of the trajectory of a particle to an electrode on impact signals still requires further exploration. Here, we investigate the particle impact measurements versus motion using micromotors with controllable vertical motion. With biocatalytic cascade reactions, the micromotor system utilizes buoyancy as the driving force, thus enabling more regulated interactions with the electrode. With the aid of numerical simulations, the dynamic interactions between the electrode and micromotors are categorized into four representative patterns: approaching, departing, approaching‐and‐departing, and departing‐and‐reapproaching, which correspond well with the experimentally observed impact signals. This study offers a possibility of exploring the dynamic interactions between the electrode and particles, shedding light on the design of new electrochemical sensors.