bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perinatal low‐fat dietary intervention affects glucose metabolism in female adult and aging offspring
Authors: Ueno Megumi , Liu Shuang , Kiyoi Takeshi , Sugiyama Takashi , Mogi Masaki 
Published: March 2022

AimDiabetes confers a high risk of developing poor health in later life in women. Based on the Developmental Origins of Health and Disease theory, the present study was undertaken to investigate the efficacy of perinatal fat restriction in maternal high‐fat‐exposed female offspring to maintain glucose homeostasis in later life between adulthood and aging.MethodsLow‐fat dietary intervention during either gestation or lactation was performed using a high‐fat diet‐induced maternal obesity mouse model (HFD mice). Physiological metabolic parameters, including body weight and serum levels of total cholesterol and triglycerides, were monitored. Glucose tolerance test and insulin sensitivity test were performed in 12‐ and 70‐week‐old offspring. Insulin‐positive islet cells were also observed using immunohistochemical staining.ResultsHFD significantly induced abnormal weight gain, hyperlipidemia and impairment of both glucose tolerance and insulin sensitivity in offspring. Standard diet intake after weaning improved weight gain, serum total cholesterol level and glucose tolerance, but not insulin sensitivity, in 70‐week‐old offspring. Only perinatal fat restriction during both gestation and lactation, followed by standard food intake for the rest of their life, provided adequate efficacy to restore insulin sensitivity in aging female progeny.ConclusionsPerinatal low‐fat intervention may prevent deterioration of glucose metabolism. To improve the health status over a female's lifespan, appropriate nutritional intervention during the early developmental stage may reset the disease trajectory and prevent the onset and development of diabetes. Geriatr Gerontol Int 2022; 22: 441–448.
Risk factors for relapse of autoimmune hepatitis in Japan: A nationwide survey
Authors: Takahashi Atsushi , Ohira Hiromasa , Abe Kazumichi , Zeniya Mikio , Abe Masanori , Arinaga‐Hino Teruko , Nakamoto Nobuhiro , Takaki Akinobu , Kang Jong‐Hon , Joshita Satoru , Suzuki Yoshiyuki , Koike Kazuhiko , Inui Ayano , Tanaka Atsushi ,   Japan Autoimmune Hepatitis Study Group
Published: March 2022

AbstractAimSome autoimmune hepatitis (AIH) patients experience relapse during their clinical course, and some risk factors for relapse have been identified previously using a relatively small sample size. The aim of the present study was to identify the risk factors for relapse in recently diagnosed AIH patients using a nationwide survey in Japan.MethodsThe nationwide survey performed in Japan in 2018 of AIH patients diagnosed between 2014 and 2017 was re‐evaluated. A total of 614 patients who received corticosteroids were enrolled in the present study. Associations between relapse and patients' characteristics at diagnosis were evaluated using logistic regression analysis.ResultsRelapse was identified in 143 (23.3%) patients after remission. At the time of diagnosis of the disease, there were significant differences in the γ‐glutamyl transpeptidase (γ‐GTP) level, prevalence of liver cirrhosis, and degree of liver fibrosis. Multivariable logistic regression analysis showed that γ‐GTP elevation and liver cirrhosis were significantly associated with relapse.ConclusionThe γ‐GTP level at diagnosis could help identify AIH patients at higher risk of relapse.
Characterisation of the molecular mechanisms of multiple antibiotic tolerance in growth‐arrested Cronobacter sakazakii under ampicillin exposure
Authors: Chen Chuxin , Ao Jialu , Wang Li , Zhang Jingfeng , Mo Yunshao , Zhang Yehui , Zhao Lichao 
Published: March 2022

SummaryCronobacter sakazakii could enter a growth‐arrested state when exposed to ampicillin. Growth‐arrested bacteria can become more tolerant to a wide range of antibiotics, posing a serious threat to food safety and human health. The aim of this study was to investigate the tolerance of growth‐arrested C. sakazakii to a variety of antibiotics and to explore the underlying mechanisms responsible for the variations in antibiotic tolerance levels. The results of the study, as tested by flat colony counting method as well as PMAxx‐qPCR, showed that growth‐arrested C. sakazakii had higher tolerance to four different antibiotics. Results validated by RT‐qPCR indicated that almost all the changes in the expression of antibiotic resistance genes in growth‐arrested cells showed a tendency to promote antibiotic tolerance compared to culturable cells, with significant upregulation of expression of the multidrug efflux pump genes in particular. Furthermore, the up‐regulated gene expression of relA and rpoS and insignificant changes in gene expression of spoT suggested that the stringent response could positively regulate the multidrug efflux pumps of growth‐arrested cells. Growth‐arrested C. sakazakii pose a potential source of contamination and should be taken into account when monitoring of food safety.
Application of induced voltage in cloudy apple juice: enzymatic browning and bioactive and flavouring compounds
Authors: Han Aye Myo , Xu Xueming , Yang Na , Jin Yamei , Jin Zhengyu , Xie Zhengjun 
Published: March 2022

SummaryControlling enzymatic browning and decreasing the loss of phenolic and flavour compounds by emerging technologies have drawn interest. In this study, magneto‐induced voltages (900–1800 V, 20‐45 kHz) with mild temperature (20–50 °C) were applied to inactivate polyphenol oxidase (PPO) and peroxidase (POD) in cloudy apple juice. Results suggested that PPO and POD activities could be reduced by 98.5% and 99.4%, respectively, following the condition: induced voltage 1800 V; frequency 45 kHz; temperature 50 °C and duration 3 min. And, phenolic compounds included gallic acid, catechin, chlorogenic acid, p‐hydroxybenzoic acid, caffeic acid, rutin and p‐coumaric acid, as well as major aroma compounds consisted of 22 volatile constituents which classified into three categories: esters, alcohols and aldehydes were also investigated. It suggested the phenolic compounds and major aroma compounds remained unchanged after the electrical treatment. This study suggests that the induced voltage produced by electromagnetic induction is an alternative to conventional heating methods.
Investigating the impact of cognitive bias in nursing documentation on decision‐making and judgement
Authors: Martin Krystle , Bickle Korri , Lok Jessica 
Published: March 2022

AbstractThe clinical documentation of patients’ mental status, behaviour and functioning is a fundamental aspect of inpatient mental health care. It is an important source of information‐sharing with the interprofessional team and used by other clinicians within the circle of care to guide their decision‐making process. Given the body of evidence highlighting concerns about the quality of nursing documentation and the growing literature demonstrating the presence of bias in healthcare, it is critically important that we examine the impact of this bias in nursing practice. The primary objective of this study was to determine whether clinical decisions and judgements change when nurses read documentation that is either biased or neutral. Using a quantitative, observational study that used surveys to collect data, participants were exposed to two patient vignettes and six clinical notes associated with each patient (notes were written with either biased or neutral language) and asked to make clinical decisions and judgements. Results from 199 nurse participants from a tertiary mental health hospital revealed a notable relationship between the type of notes read (biased vs. neutral) and clinical practice, namely, participants reading biased notes were less likely to offer health teaching when administering pro re nata (PRN) medication for sleep. We also found differences in decision‐making and judgements based on the type of note read depending on years of experience and type of education. The results indicate that biased language in nursing documentation can influence other clinicians’ decisions and judgements about patients, thereby indicating a cascade of bias.
The diffuse interface phase‐field model for in situ interlayer phase formations in low‐temperature reaction bonding of alumina laminates—A theoretical and experimental comparison
Authors: Hosseinabadi Navid 
Published: March 2022

AbstractA diffuse interface phase‐field model is developed to study alumina seamless laminate composites formation via reaction interlayer diffusion bonding. The model was designed to indicate the important role of interface on phase transition and interfacial chemical reactions. The model has indicated the interfacial reactions, phase transitions, and phase evolution along the alumina/reaction layer interface. The theoretical results were assessed, validated, and confirmed by experimental data at similar bonding conditions via targeted diffusion bonding in aluminum‐alkaline earth hydride and alanate interlayer systems Me (Me: Mg–Sr). The alanates and hydrides dissociations left pockets of intermetallic phases at interlayer as bonding constituents. The solid‐state bonds have formed by diffusion bonding at laminate interfaces and partial oxidations. The elemental analysis showed the alkaline earth rich zones at interlayer and near interfaces. The crystalline composition of the interlayer materials was combinations of polycrystalline mixed oxide layers, formed due to different oxidation kinetics and diffusion rates. Interlayer oxidation products were combination of complex oxides with SruMgxAlyOz (u: 0.8–1, x: 0.7–1, y: 2–10, z: 4–17) stoichiometry.
The magnetic, thermal transport properties, magnetothermal effect and critical behavior of Co3Sn2S2 single crystal
Authors: Hu Jiyu , Kan Xucai , Chen Zheng , Zheng Ganhong , Ma Yongqing 
Published: March 2022

AbstractThrough the magnetic/thermal transport measurements combined with the analyses of magnetocaloric effect and critical behavior of Co3Sn2S2 single crystal, the main results we obtained are as follows: in the case of the magnetic field H//c‐axis, Co3Sn2S2 exhibits the phase‐separation state below Tc in the low‐field region (H < 500 Oe). Tc increases slightly from 174 to 177 K with an increase in H from 100 to 10 kOe. The second‐order magnetic phase transition near Tc and the itinerant ferromagnetism below Tc are identified. The magnetization below Tc matches well with the three‐dimensional Ising model, instead of the mean‐field model. In the case of H//ab, Tc changes between 175 and 178 K with varying H. Noticeably, M above Tc exhibits a small positive value, instead of the null M as commonly expected in the paramagnetic region. An extra phase transition below 166 K is observed. The magnetic transition near Tc seems not to be the second‐order phase transition. All results show a significant characteristic of anisotropic magnetic phase transition for the Co3Sn2S2 single crystal. They support mutually those in previous reports, moreover, some new phenomena are also observed. They also provide the experimental evidences for the deep insight into the magnetic phase–transition behavior of Co3Sn2S2.
Antibacterial activity of palmarosa oil significantly varies between Aeromonas veronii and Aeromonas caviae and exhibits selective action on tetracycline and sulfonamide resistant A. caviae
Authors: Kumar Chandra Bhushan , Kumar Anil , Rathore Gaurav 
Published: March 2022

Abstract

Aims
To investigate the antibacterial activity of three (palmarosa, basil and rosemary) essential oils (EOs) on Aeromonas veronii and Aeromonas caviae, and determine minimum inhibitory concentration (MIC) of potent EO against tetracycline and sulfonamide resistant strains.

Methods and Results
Palmarosa oil (PMO) showed significantly (p &lt; 0.05) higher inhibition zones against both A. veronii and A. caviae (n = 30) than basil and rosemary in the disk diffusion assay. The MIC (% v/v) of PMO ranged from 0.008% to 1.00%. The mean MIC was significantly higher for A. caviae (0.48 ± 0.24%) than A. veronii (0.21 ± 0.15%). Further, the MIC of PMO was compared in six groups: Group 1: Tetracycline Resistant A. veronii (TRV); Group 2: Tetracycline Resistant A. caviae (TRC); Group 3: Sulfonamide Resistant A. veronii (SRV); Group 4: Sulfonamide Resistant A. caviae (SRC); Group 5: Susceptible A. veronii (SV) and Group 6: Susceptible A. caviae (SC). No significant differences were observed between overall resistant (TRV+ SRV) and susceptible A. veronii (SV). However, in A. caviae, the resistant group had a lower MIC than the susceptible group. Moreover, the MIC was significantly lower for TRC (0.31 ± 0.11%) as compared to SRC (0.46 ± 0.10%). The time of kill of PMO for both the species of Aeromonas was 20–30 min.

Conclusion
Palmarosa oil exhibited significantly higher activity on A. veronii than A. caviae. The resistant strains of A. caviae were inhibited at a lower concentration than susceptible strains.

Significance and Impact of the Study
Palmarosa oil could be explored as an alternative antimicrobial agent for mitigating antimicrobial resistance and managing Aeromonas infection in fish and their risks to public health.
Do the drivers and levels of isolation in fish faunas differ across Atlantic and Pacific drainages in the Americas?
Authors: Griffiths David 
Published: March 2022

AbstractAimThe roles of physical barriers to dispersal and species' abilities to cross barriers have in shaping freshwater fish distributions has been little explored at the macroscale. This study investigates how topography and species migratory behaviours and salinity tolerances (vagility) affect catchment isolation, species richness, large‐scale distribution patterns and turnover across latitudes and coasts.LocationNorth (NAm), Middle (MAm) and South (SAm) America.TaxonFish.MethodsFrom a large, published, dataset Pacific and Atlantic coast catchments in NAm, MAm and SAm were allocated to six georegions and species richness and composition correlated with information on catchment size, channel gradient and discharge. Catchment species richnesses, species–area relations (SAR), endemicity and turnover relationships were examined across coasts and latitude for species with different migratory behaviours and salinity tolerances.ResultsPacific coast rivers are smaller, steeper, hydrologically more variable and have narrower marine shelves than Atlantic ones, except in MAm. Catchment isolation is greater in Pacific drainages but the barriers to species exchange differ across georegions. Species richnesses are greater in Atlantic drainages but the proportion of vagile species is smaller. SAR slopes are flatter in vagile species and endemicity less. Turnover varies with catchment topography, the relative contribution of vagile species and, in MAm, on evolutionary history.Main conclusionsTectonic and geomorphic processes influence catchment size and topography, and along with species differences in dispersal potential, affect how isolated catchments are, with consequences for species richness and composition.
Effects of goal‐oriented care for adults with multimorbidity: A systematic review and meta‐analysis
Authors: Barbato Angelo , D'Avanzo Barbara , Cinquini Michela , Fittipaldo Andrea Veronica , Nobili Alessandro , Amato Laura , Vecchi Simona , Onder Graziano 
Published: March 2022

AbstractObjectiveTo systematically review the evidence from randomized controlled trials comparing the effects of goal‐oriented care against standard care for multimorbid adults.Data Sources/Study SettingThe literature presenting the results of randomized trials assessing the outcomes of goal‐oriented care compared with usual care for adults with multimorbidity.Study DesignSystematic review and meta‐analysis.Data Collection/Extraction MethodsWe searched the Cochrane Database of Systematic Reviews (CENTRAL), EMBASE, MEDLINE, CINHAL, trial registries such as ClinicalTrial.gov and World Health Organization International Clinical Trials Registry Platform (ICTRP), and the references of eligible trials and relevant reviews. Goal‐oriented care was defined as an approach that engages patients, establishes personal goals, and sets targets for patients and clinicians to plan a course of action and measure outcome. We reviewed 228 trials, and 12 were included. We extracted outcome data on quality of life, hospital admission, patients' satisfaction, patient and caregiver burden. Risk of bias was assessed and certainty of evidence was evaluated using GRADE.Principal FindingsNo study was fully free of bias. No effect was found on quality of life (standardized mean difference [SMD]: 0.05; 95% CI: −0.05 to 0.16) and hospital admission (risk ratio [RR]: 0.87; 95% CI: 0.65 to 1.17). There was a very small effect for patients' satisfaction (SMD: 0.15; 95% CI: 0.00 to 0.29) and caregiver burden (SMD: −0.13; 95% CI: −0.26 to 0.00). Certainty of evidence was low for all outcomes.ConclusionsNo firm conclusions can be reached about the effects of goal‐oriented care for multimorbid adults. Future research should overcome the shortcomings of trials assessed in this meta‐analysis. Sound application of the indications for research of complex healthcare interventions is warranted.
Techno‐economic evaluation of a process for the transformation of VitAto sweet potato into value‐added products
Authors: Mokhtar Mohd Noriznan 
Published: March 2022

AbstractVitAto is a popular orange sweet potato (SP) variety in Malaysia that is easy to grow, produces a large yield, and contains more nutritional components. VitAto flour is a significant ingredient in a variety of food compositions; nevertheless, establishing a cost‐effective process design is critical. Five potential process scenarios were built using the SuperPro Designer simulator, with a VitAto plant capacity of 4,000 kg/h and additional income from byproducts such as VitAto juice and VitAto protein. Purchasing cost (PC), capital expenditure (CAPEX), operating expenditure (OPEX), and net present value (NPV) were used to compare the suggested projects in order to find the most efficient and profitable ones. The alternate procedure for producing VitAto juice yields a higher NPV (US$ 13,830,000–US$ 13,867,000/year). According to the data, VitAto juice is the most profitable product, accounting for 52–60% of overall project revenue. As a result, implementing a process with water recycling and byproducts revenue can be a more profitable and long‐term project that will benefit Malaysia's low‐ and middle‐income rural areas.Practical ApplicationsViTAto's current applicability is primarily for traditional meals. It has been recognized that it has a lot of potential in the cookie and baking industries. The VitAto must be turned into flour after harvesting to enable for longer storage. Designing a modernized VitAto flour processing facility with a wastewater treatment facility (process water recycling) is costly and keeping the flour price low is difficult. Therefore, comparing different process design configurations and conducting a techno‐economical study is critical. It is thought that incorporating byproducts into the production process can boost project revenue. As a result, it would benefit farmers in rural areas where VitAto could be marketed at a competitive price. The manufacturing process also produces compostable biomass, which farmers can use in their planted fields. This mutually beneficial relationship between farmers and millers is critical for enhancing their quality of life while also benefiting the environment.
Recent developments in ohmic technology for clean label fruit and vegetable processing: An overview
Authors: Roobab Ume , Khan Abdul Waheed , Irfan Muhammad , Madni Ghulam Muhammad , Zeng Xin‐An , Nawaz Asad , Walayat Noman , Manzoor Muhammad Faisal , Aadil Rana Muhammad 
Published: March 2022

AbstractThe commercial future of any food and its ingredients is mostly determined by consumer perceptions and preferences following their lifestyle. However, health‐conscious and educated consumers are increasingly deliberated on natural, minimally processed foods. Accordingly, academic interest in food processing has expanded to maintain the degree of product freshness. But the scope of these published studies is broad and fragmented while there is limited research that systematically evaluates emerging technologies such as ohmic heating (OH) in clean‐label applications in fruit and vegetable sector. OH applies an electric current endorsing uniform and quick heat generation inside the food matrix. Furthermore, OH has shorter processing times, which inhibits overheating and causes less deterioration of heat‐labile nutrients. This study presents a comprehensive overview of advanced OH applications for inactivation of degrading enzymes and conserving natural properties of food when compared with conventional heating such as pasteurization or sterilization. Moreover, the OH combinations with nonthermal techniques such as vacuum, dehydration/drying, and evaporation/concentration have been discussed.Practical applicationsOH technology is considered very useful for producing products as “clean labeled.” Among the advantages of using OH for food processing and preservation purposes, it is very important to maintain antimicrobial properties, many nutrients and pro‐health components in processed fruit and vegetable products. OH has high potential and wide scope in future for various unit operations such as dehydration, evaporation, blanching and extraction for the food and vegetable sector. These are subjected to continuous investigation as per consumer demand without compromising safety. And due to energy savings (short process time), the possibility of using it in sustainable food production techniques.