bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbon‐Shielded Single‐Atom Alloy Material Family for Multi‐Functional Electrocatalysis
Authors: Tong Yueyu , Liu Jiaxin , Wang Liqun , Su Bing‐Jian , Wu Kuang‐Hsu , Juang Jenh‐Yih , Hou Feng , Yin Lichang , Dou Shi Xue , Liu Jian , Liang Ji 
Published: August 2022

AbstractEncapsulating metal‐based catalysts inside carbon sheaths is a frequently‐adopted strategy to enhance their durability under various harsh situations and improve their catalytic activity simultaneously. Such carbon encapsulation, however, imposes significant complications for directly modifying materials’ surface atomic/electronic configurations, fundamentally impeding the accurate tuning of their catalytic capabilities. Herein, a universal single‐atom alloy (SAA) strategy is reported to indirectly yet precisely manipulate the surface electronic structure of carbon‐encapsulated electrocatalysts. By versatilely constructing a SAA core inside an N‐doped carbon sheath, material's electrocatalytic capability can be flexibly tuned. The one with Ru‐SAA cores serves as an excellent bifunctional electrocatalyst for oxygen/hydrogen evolution, exhibiting minimal cell voltage of 1.55 V (10 mA cm−2) and outstanding mass activity of 1251 mA m for overall water splitting, while the one with Ir‐SAA cores possesses superior oxygen reduction activity with a half‐wave potential of 919 mV. Density functional theory calculations reveal that the doped atoms can simultaneously optimize the adsorption of protons (H*) and oxygenated intermediates (OH*, O*, and OOH*) to achieve the remarkable thermoneutral hydrogen evolution and enhanced oxygen evolution. This work thus demonstrates a versatile strategy to precisely modify the surface electronic properties of carbon‐shielded materials for optimized performances.
Visible‐Blind Deep Ultraviolet Photomultiplication Organic Photodetectors with Ultrahigh Gain for UVB and UVC Light Detection
Authors: Yang Liqing , Yang Dezhi , Guo Dechao , Zheng Jingbo , Tao Sizhe , Li Ji , He Guo , Ma Dongge 
Published: August 2022

AbstractPhotomultiplication‐type organic photodetectors (PM‐OPDs) have developed rapidly in UVA, visible and near‐infrared ranges, but they face great challenges in the UVB and UVC ranges, mainly due to the difficulty of simultaneously realizing deep UV light‐transmittance electrode and high gain structure. Here, the copper and silver bilayer composite electrodes are developed to overcome the problem of silver island growth, thus ensuring high deep UV light transmittance and good matching with electrical gain mechanism. The fabricated device shows high external quantum efficiency as high as 195,665% at 255 nm in UVC region. Furthermore, the above electrodes are integrated with low‐cost UV filter glass ZWB1 by simple vacuum evaporation. Finally, low‐cost visible‐blind deep UV PM‐OPDs with a rejection ratio of up to 4788 is achieved through an additional strategy of adjusting the absorption spectrum of the active layer. Benefiting from its fast response speed, the device can be directly applied to faint flame monitoring in real‐time.
A High‐Performance Self‐Powered Photodetector Based on MAPbBr3 Single Crystal Thin Film/MoS2 Vertical Van Der Waals Heterostructure
Authors: Xu Zhongquan , Zeng Yonghong , Meng Fanxu , Gao Shan , Fan Sidi , Liu Yi , Zhang Yule , Wageh Swelm , Al‐Ghamdi Ahmed A. , Xiao Jing , Guo Zhinan , Zhang Han 
Published: August 2022

AbstractMethylammonium lead bromide (MAPbBr3) single crystal thin film shows great opportunities in high‐performance optoelectronic devices due to its high absorption coefficient, high photoelectric conversion efficiency, and low trap‐state density properties. In order to fabricate a highly sensitive self‐powered photodetectors, herein, a MAPbBr3 single crystal thin film/molybdenum disulfide (MoS2) vertical p‐n heterostructure based photodetector has been built by typical polymer film assisted dry transfer method and micromachining technique. Attributing to the built‐in electric field and the shortened transmit distance for the photogenerated carriers in this heterostructure, the device shows excellent photovoltaic characteristics with a maximum output electrical power of 7 nW and power conversion efficiency of 8% at 0.34 V under 532 nm laser. Moreover, prominent photoelectric properties with responsivity of 368 mA W−1 and detectivity of 3.74 × 1012 Jones for 532 nm laser without any bias have been achieved, which are ranking high among the organic–inorganic hybrid perovskites based self‐power photodetectors. These results demonstrate that the MAPbBr3 single crystal thin film/MoS2 vertical heterostructure can pave a new way to develop high‐performance photovoltaic devices.
A Pathway to Fabricate Gallium Nitride Embedded 3D High‐Index‐Contrast Optical Structures
Authors: ElAfandy Rami T. , Mi Chenziyi , Wang Sizhen , Han Jung 
Published: August 2022

AbstractOptical engineering of gallium nitride (GaN) semiconductor material has enabled novel applications and technologies. 3D optical engineering is challenging and mostly accomplished by surface‐level patterning with subtractive or additive means. In this work a pathway, based on epitaxial conductivity control in conjunction with ion implant and subsequent electrochemical etching, to generate complex embedded nanoporous (NP)‐GaN/GaN or air/GaN 3D optical structures is presented. A range of subsurface structures is demonstrated including in‐plane NP‐GaN stripes and curved patterns, air/GaN microchannels, and localized, embedded distributed Bragg reflectors (DBRs) as micromirrors. To further demonstrate the versatility of the technique, adjacent DBR micromirrors, of different thicknesses, embedded depths, and widths, are created in the same fabrication steps. Computer simulations are used to shed light on the limitations of feature sizes of the presented technique. The approach is a simple, scalable, and versatile approach for fabricating embedded 3D optical structures readily extendable beyond GaN semiconductors.
Preparation and Evaluation of Sterically Hindered Acridine Photocatalysts
Authors: Zhilyaev Kirill A. , Lipilin Dmitry L. , Kosobokov Mikhail D. , Samigullina Aida I. , Dilman Alexander D. 
Published: August 2022

AbstractA practical nickel‐catalyzed protocol for the synthesis of sterically hindered 9‐arylacridines via Negishi type cross‐coupling was developed. The method enables a convenient approach to a set of active acridine photocatalysts starting from commercially available 9‐chloroacridine, inexpensive catalyst [NiCl2(Ph3P)2], and organozinc reagent with no need for additional ligands and precious metals. The synthetic protocol could be readily performed on a gram scale. The photocatalytic efficiency of obtained acridines was tested in decarboxylative thiolation and amination reactions. Structures of 19 acridines were studied by X‐ray analysis, which allowed to propose a steric descriptor relevant to the catalytic activity.magnified image
First report of a short in‐frame biallelic deletion removing part of the EGF‐like domain calcium‐binding motif in LTBP4 and causing autosomal recessive cutis laxa type 1C
Authors: Ravel Jean‐Marie , Comel Margot , Wandzel Marion , Bronner Myriam , Tatopoulos Aurélie , Renaud Mathilde , Lambert Laëtitia , Bursztejn Anne‐Claire , Bonnet Céline 
Published: August 2022

AbstractCutis laxa (CL) is a rare connective tissue disorder characterized by wrinkled, abundant and sagging skin, sometimes associated with systemic impairment. Biallelic alterations in latent transforming growth factor beta‐binding protein 4 gene (LTBP4) cause autosomal recessive type 1C cutis laxa (ARCL1C, MIM #613177). The present report describes the case of a 17‐months‐old girl with cutis laxa together with a literature review of previous ARCL1C cases. Based on proband main clinical signs (cutis laxa and pulmonary emphysema), clinical exome sequencing (CES) was performed and showed a new nine base‐pairs homozygous in‐frame deletion in LTBP4 gene. RT‐PCR and cDNA Sanger sequencing were performed in order to clarify its impact on RNA. This report demonstrates that a genetic alteration in the EGF‐like 14 domain calcium‐binding motif of LTBP4 gene is likely responsible for cutis laxa in our patient.
Tetrazine Linkers as Plug‐and‐Play Tags for General Metal‐Organic Framework Functionalization and C60 Conjugation
Authors: Lerma‐Berlanga Belén , Ganivet Carolina R. , Almora‐Barrios Neyvis , Vismara Rebecca , Navarro Jorge A. R. , Tatay Sergio , Padial Natalia M. , Martí‐Gastaldo Carlos 
Published: August 2022

AbstractThe value of covalent post‐synthetic modification in expanding the chemistry and pore versatility of reticular solids is well documented. Here we use mesoporous crystals of the metal–organic framework (MOF) UiO‐68‐TZDC to demonstrate the value of tetrazine connectors for all‐purpose inverse electron‐demand Diels–Alder ligation chemistry. Our results suggest a positive effect of tetrazine reticulation over its reactivity for quantitative one‐step functionalization with a broad scope of alkene or alkyne dienophiles into pyridazine and dihydropyridazine frameworks. This permits generating multiple pore environments with diverse chemical functionalities and the expected accessible porosities, that is also extended to the synthesis of crystalline fulleretic materials by covalent conjugation of fullerene molecules.
Unshared Pair Electrons of Zincophilic Lewis Base Enable Long‐life Zn Anodes under “Three High” Conditions
Authors: Zhou Lijun , Wang Fuxin , Yang Fan , Liu Xiaoqing , Yu Yanxia , Zheng Dezhou , Lu Xihong 
Published: August 2022

AbstractThe hydrogen evolution and dendrite issues are the notorious culprits of the limited lifespan and Coulombic efficiency (CE) of Zn anodes, particularly at harsh test conditions. Herein, considering the Lewis acidic feature of Zn2+, abundant unshared pair electrons of zincophilic Lewis bases are proposed as decent electrolyte additives to stabilize Zn anodes at “Three High” conditions (high depth of discharge, high areal capacity and high current). The unshared pair electrons can remove H2O from Zn2+ solvated sheaths and confine the activity of H2O by breaking its hydrogen bonding network. The combination of these factors effectively restricts H2O‐involved side reactions and enables dendrite‐free Zn deposition, even at harsh conditions. The effectiveness of this strategy is fully proved by a series of Lewis base molecules. Noticeably, the Zn||Zn cell with an area of 20 cm2, using DMF‐containing electrolyte can be stably cycled over 1000 h at 60 % DOD, with a 100 % CE.
Dearomative Aminocarbonylation of Arenes via Bifunctional Coordination to Chromium
Authors: Wang Ming‐Yang , Wu Cheng‐Jie , Zeng Wei‐Long , Jiang Xu , Li Wei 
Published: August 2022

AbstractAmides are ubiquitous in physical and life sciences. Given the significant abundance of arenes, dearomative aminocarbonylation of arenes would lead to a large and underexplored chemical space for amide discovery. However, such reactions are challenging due to the high degree of resonance stabilization and selectivity issues. Herein, we disclose an unprecedented dearomative trifluoromethylative aminocarbonylation of arenes via bifunctional coordination to chromium, providing a modular platform for the construction of amides possessing trifluoromethyl (CF3) groups and three‐dimensional rings. Its versatility further enabled a switchable difluoromethylation or trifluoromethylation aminocarbonylation of arene C−H bonds. A possible mechanism was proposed based on control experiments. Finally, the synthetic utility was well demonstrated by diverse applications in the total synthesis of CF3‐functionalized amide‐type drugs, including praziquantel, nateglinide, maraviroc and alloyohimbane.
Synthesis of novel methacrylate‐based nanocomposites containing ZnO via the hydrothermal method and determination of thermal, optical, and biocidal properties
Authors: Erol Ibrahim , Aksu Mecit , Gürler Zeki 
Published: August 2022

AbstractIn this work, the hydrothermal method was used to prepare nanocomposites of a new methacrylate polymer (PFPAMA) carrying the aryl fluoro group in the side branch and containing different mass ratios (1%, 3%, and 5%) of nano ZnO. Morphological and structural properties of the PFPAMA‐ZnO nanocomposites were determined via scanning electron microscope, transmission electron microscopy, Fourier transform infrared, ultraviolet (UV), and X‐ray diffraction, whereas the thermal properties of the nanocomposites were determined using thermogravimetric analysis (TGA) and differential scanning calorimetry techniques. The obtained results showed that the thermal stability and glass transition temperature (Tg) of the nanocomposites had increased with the increase in the amount of ZnO. Thermal degradation activation energies (Ea) of the nanocomposites were calculated via non‐isothermal TGA experiments using the Flynn–Wall–Ozawa and Kissinger–Akahira–Sunose methods. Both calculated Ea values were compatible with each other and increased in parallel with the ZnO increases. The UV measurements showed that the ZnO nanoparticles added to the PFPAMA played an important role as a UV barrier, and thus expanding the potential applications of the PFPAMA polymer. Finally, the biological activities of the PFPAMA/ZnO nanocomposites against Gram‐positive (Staphylococcus aureus) and Gram‐negative (Escherichia coli) bacteria were also tested.
Investigation of the carbonic anhydrase inhibitory activity of benzenesulfonamides incorporating substituted fused‐pyrimidine tails
Authors: Abdel‐Mohsen Heba T. , Petreni Andrea , Supuran Claudiu T. 
Published: August 2022

AbstractTwo new series of 2‐thiocyclopenta[d]pyrimidine‐benzenesulfonamides 12a–l and 2‐thiotetrahydroquinazoline‐benzenesulfonamides 13a–j were synthesized and evaluated for their carbonic anhydrase (CA, EC 4.2.1.1) inhibitory acivity and cytotoxic activity. The derivatives 12a and 12i exerted effective inhibition against CA II with Ki = 0.11 and 0.15 µM, while 12a, 12e, 12i, and 13d (Ki = 0.083–0.087 µM) were found to be the most potent against CA XII. In addition, higher selectivity toward CA II and CA XII over CA I and CA IX was observed for the majority of the synthesized conjugates. Analysis of the effect of the synthesized compounds on NCI cancer cell lines revealed that compounds 12b and 13d showed mean growth inhibitory effects of 53.59% and 49.25%, respectively. Docking of the synthesized hybrids in the CA II and CA XII binding pockets displayed the capability of the benzenesulfonamide derivatives to form, through their SO2NH2 moiety, the characteristic interactions of the traditional CA inhibitors, besides additional interactions achieved by the tail with isoform‐specific residues in the peripheral part of the CA binding sites.
HPLC and GC–MS–based metabolic profiles and in vivo anticonvulsant, sedative, and antinociceptive potentials of truffles Tirmania nivea and Tirmania pinoyi hydromethanolic extracts in mice
Authors: Aboutabl Mona E. , Elkhateeb Waill A. , Masoud Marwa A. , Daba Ghoson M. , Afifi Ahmed H. , Hussein Rehab A. 
Published: August 2022

AbstractGC–MS and HPLC analyses of the hydromethanolic extracts of the truffles Tirmania nivea (TN) and Tirmania pinoyi (TP) revealed the presence of 18 metabolites and 11 polyphenols, respectively. In vivo, TP extract protected against subcutaneous pentylenetetrazole (scPTZ) and maximal electric shock (MES)‐induced convulsions faster than TN extract. TP extract (100 and 300 mg/kg) showed 100% protection and longer duration than TN extract in the scPTZ test. Similarly, at 300 mg/kg, TP demonstrated a quicker start (75%) and longer duration of action (100%) than TN in MES test. In the scPTZ test, ED50 of TP demonstrated greater anticonvulsant efficacy than that of TN. In mice given TP and TN treatments, the brain GABA levels noticeably increased. TP (100 and 300 mg/kg) produced a notable sedative effect in open‐field test, whereas TN (100 or 300 mg/kg) and TP (300 mg/kg) reduced sleep latency by 52%, 45%, and 79%, respectively. In writhing test, TN (100 or 300 mg/kg) significantly enhanced analgesic efficacy by 50 and 87%, respectively. Comparatively, in formalin test, TP and TN at a dosage of 300 mg/kg decreased the length of the licking by 34 and 59%, respectively. For the first time, this study explains the anticonvulsant, sedative, central, and peripheral analgesic activities of truffle extracts.
CircSERPINA3 promoted cell proliferation, migration, and invasion of laryngeal squamous cell carcinoma by targeting miR‐885‐5p
Authors: Xu Qiushi , Yu Bing , Chen Wenjing , Li Wenlong , Sun Yuanhao , Fang Yanchun 
Published: August 2022

AbstractCircSERPINA3 has been shown to be upregulated in laryngeal squamous cell carcinoma (LSCC); however, whether it regulates the development of LSCC and the specific molecular mechanism remains unclear, which is to be explored in this study. Expressions of circSERPINA3, miR‐885‐5p, and Malic enzyme 1 (ME1) in LSCC tissues or cell lines were determined by quantitative reverse transcription polymerase chain reaction (qRT‐PCR). The regulation of circSERPINA3 on the biological behavior of LSCC cells was confirmed by loss and gain experiments (cell counting kit‐8, transwell, and colony formation assay). The correlation between circSERPINA3/ME1 and miR‐885‐5p was predicted and confirmed by bioinformatics analysis, dual‐luciferase reporter assay, and qRT‐PCR. The effect of circSERPINA3/miR‐885‐5p axis on the biological behavior of LSCC cells and expressions of epithelial–mesenchymal transition‐related proteins was confirmed by rescue experiments. CircSERPINA3 and ME1 was upregulated in LSCC tissues, whereas miR‐885‐5p was downregulated. MiR‐885‐5p was the target gene of circSERPINA3, whereas ME1 was the target gene of miR‐885‐5p. Silent circSERPINA3 suppressed viability, invasion, migration, colony formation, and expression of ME1, claudin‐4, snail, and vimentin but elevated expression of miR‐885‐5p and E‐cadherin, whereas overexpressed circSERPINA3 was the opposite. However, miR‐885‐5p inhibitor or mimic reversed the effects of silent circSERPINA3 or overexpressed circSERPINA3. Collectively, circSERPINA3 promotes proliferation, migration, and invasion of LSCC cells by targeting miR‐885‐5p.
SARM suppresses glioma progression in GL261 glioma cells and regulates microglial polarization
Authors: Zhou Chun , Li Tianzun , Dong Qian , Liang Hong , Xu Lunshan 
Published: August 2022

AbstractMicroglia is the major cellular component of glioma mass that promotes glioma growth, invasion, and chemoresistance by releasing inflammatory factors. Sterile alpha and HEAT/Armadillo motif (SARM), a member of the Toll‐interleukin‐1 receptor (TIR) domain‐containing adaptor family, is primarily expressed in the central nervous system. However, the role of SARM in glioma is still undefined. In the present work, we examined the function of SARM in microglial polarization and glioma progression. Our results showed that forced the expression of SARM in GL261 glioma cells inhibited tumor growth, and reduced interleukin (IL)‐6 secretion in conditioned media. Silencing of SARM in microglia cells inhibited IL‐4‐induced M2 polarization, enhanced lipopolysaccharide ‐induced M1 microglial polarization. Furthermore, overexpression of SARM increased the migration of microglia cells upon TGFβ stimulation. These data suggested that SARM is involved in neuro‐inflammation and microglia activation. In summary, this study provides novel insight into the mechanisms of microglial polarization.
Porcn as a novel therapeutic target in cancer therapy:  A review
Authors: Raeisi Mortaza , Saberivand Maryam , Velaei Kobra , Aghaei Negar , Rahimi‐Farsi Nasim , Kharrati‐Shishavan Hengameh , Hassanzadeh Davoud , Mehdizadeh Amir 
Published: August 2022

AbstractWingless‐related integration site (Wnt) signaling is one of the main oncogenic pathways in different malignancies. Therefore, targeting this pathway has been considered an exciting strategy in cancer treatment. Porcn is among the central enzymes in this pathway that has recently been considered for cancer‐targeted therapy. As a membrane‐bound O‐acyltransferase, Porcn plays a critical role in wnt ligand palmitoylation and its subsequent secretion. In addition to Porcn's role in stem cell signaling and differentiation, recent findings have shown its role in developing and progressing colorectal, pancreatic, liver, head, and neck cancers. Developed small molecule inhibitors have also opened a promising window toward cancer treatment strategies. In this review, the structure and biological role of Porcn in different cancer‐related signaling pathways and inhibitors used for inhibiting this enzyme are discussed.
Chemiluminescent Imaging Assay of SARS‐CoV‐2 Protein with Target‐Induced Enzyme Activity Regulation
Authors: Chen Yuhui , Ao Hang , Xiao Wencheng , Ju Huangxian , Wu Jie 
Published: August 2022

AbstractSimple but robust testing assays are essential for screening and diagnosis of individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in COVID‐19 pandemic. Here, we described a chemiluminescent imaging assay (CLIA) for sensitive and convenient detection of SARS‐CoV‐2 nucleocapsid protein (NP) by a target‐induced enzyme activity regulation (T‐EAR) strategy. The T‐EAR used a pair of antibody‐DNA probes to recognize SARS‐CoV‐2 NP and proximity‐induce rolling circle amplification for mass‐production of pyrophosphate to coordinate with Cu2+, which prevented the reduction of Cu2+ to Cu+ by sodium ascorbate as well as the Cu+‐caused inactivation of horseradish peroxidase (HRP). The activity retention of HRP produced strong CL signal for the detection of SARS‐CoV‐2 NP by catalyzing the oxidation of luminol by H2O2. The T‐EAR based CLIA showed a wide detection range from 1 pg/mL to 100 ng/mL (13 fM to 1.3 nM) with the requirement of only 0.75 μL of sample. This CLIA had advantages of good sensitivity, simple wash‐free operation, acceptable accuracy, and high‐throughput imaging detection, displaying potential applicability in screening assay of COVID‐19 infection.
Dual MOF‐Derived MoS2/CdS Photocatalysts with Rich Sulfur Vacancies for Efficient Hydrogen Evolution Reaction
Authors: Shi Jinyan , Yang Le , Zhang Jie , Wang Zejin , Zhu Wenbo , Wang Ying , Zou Zhigang 
Published: August 2022

AbstractCocatalyst plays an important role in efficient charge transfer and separation for photocatalysis. Herein, a MoS2/CdS photocatalyst with MoS2 as cocatalyst was designed by using Mo‐MOF and Cd‐MOF as precursors. Due to the existence of rich sulfur vacancies and 1T phase, MoS2 shows strong charge capture and transport ability. The photo‐generated electrons on conduction band (CB) can be bound by the sulfur vacancy of CdS and effectively transported to MoS2 through the compact interface between the CdS nanoparticles and 2D large‐scale MoS2. The optimal photocatalyst 1 %MoS2/CdS exhibited dramatically improved photocatalytic hydrogen production activity, which is 28 times that of pristine CdS and even about 2 times that of 1 %Pt/CdS with same loading amount of noble metal Pt. This work highlights the role of Mo‐MOF derived MoS2 with 1T‐2H phases as a sustainable and prospective candidate of cocatalyst for improving charge separation and photocatalytic stability of MoS2/CdS composites.