bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Anisotropy on the Quality of Laser Cutting Corner of CFRP Plate
Authors: Li Wenyuan , Huang Yu , Chen Long , Chen Xinghua , Zhang Guojun , Rong Youmin 
Published: June 2022

Abstract
Carbon fiber reinforced polymer (CFRP) composites are widely used in the aerospace field because of their outstanding performance. Laser is an effective method for CFRP composite processing. However, there are corner errors and obvious thermal damage in laser corner cutting, which affect the cutting quality. This article mainly describes the corner error and thermal damage behavior, and the effect of anisotropy of nanosecond UV laser when cutting different corners of CFRP plates. Select six corner angles to perform a full factorial experiment with a right-angled triangle hole cutting under the horizontal and vertical baselines and different laser repetition rates. The results show that there are obvious corner errors and heat affected zone (HAZ) and matrix recession (MR) in laser corner cutting. The corner error always shows that the cut-in error is smaller than the cut-out error (28.06% on average), and the cut-in error and HAZ decrease with the increase of the corner angle, but the difference between the cut-in and the cut-out error increases with the increase of the corner angle. In vertical baseline cutting, the corner error can be reduced to a certain extent, but the HAZ (average 38.42%) is seriously increased, and the thermal damage of linear cutting under a large pulse repetition rate is increased. The large laser repetition rate increases the thermal damage due to the increase of the overlap rate of adjacent pulses but has less effect on the corner error, especially the cut-in error.
Prediction and Control of Product Shape Quality for Wire and Arc Additive Manufacturing
Authors: Ruiz Cesar , Jafari Davoud , Venkata Subramanian Vignesh , Vaneker Tom H. J. , Ya Wei , Huang Qiang 
Published: June 2022

Abstract
Wire and arc additive manufacturing (WAAM) has become an economically viable option for fast fabrication of large near-net shape parts using high-value materials in the aerospace and petroleum industries. However, wide adoption of WAAM technologies has been limited by low shape accuracy, high surface roughness, and poor reproducibility. Since WAAM part quality is affected by a multitude of factors related to part geometries, materials, and process parameters, experimental characterization or physics-based simulation for WAAM process optimization can be cost prohibitive, particularly for new part designs. As an effective alternative, data-analytical approaches have been developed for prescriptive modeling and compensation of shape deviations in 3D printed parts. However, WAAM faces a unique challenge of large shape deviation and high surface roughness at the same time. Accurate prediction and control of WAAM part quality require process-meaningful error decomposition under geometric measurement uncertainties. We propose a generalized additive modeling approach to separate global geometric shape deformation from surface roughness. Under this statistical framework, tensor product basis expansion is adopted to learn both the low-order shape deformation and high-order roughness patterns. The established predictive model enables optimal geometric compensation for product redesign to reduce shape deformation from the target geometry without altering process parameters. Experimental validation on WAAM manufactured cylindrical walls of various radii shows the effectiveness of the proposed framework.
Synthesis and Structural Diversity of Gadolinium 1-(o-Methoxyphenyl)-3,4-diphenylcyclopentadienyl Complexes
Authors: Bardonov D. A. , Lysenko K. A. , Nifant’ev I. E. , Roitershtein D. M. 
Published: June 2022

Abstract
The reaction of 1-(o-methoxyphenyl)-3,4-diphenylcyclopentadienyl potassium with gadolinium chloride tetrahydrofuranate gives, depending on the stoichiometry, either tetranuclear complex [{[η5-(Ph2(o-CH3OC6H4)C5H2)Gd(Thf)]2(µ2-Cl)2(µ3-Cl)3K(Thf)}2] (I) or mononuclear complex [(Ph2(o-CH3OC6H4)C5H2)2GdCl] (II) (CIF files CCDC nos. 2116742 (I), 2116741 (II)). In complex I, the oxygen atom of the methoxy group is not coordinated to the gadolinium cation, whereas in complex II, the Gd3+ cation is coordinated to the oxygen atoms of both methoxy groups. Complex II crystallizes in the chiral space group P41212.
Use of traditional medicine and control of hypertension in 12 African countries
Authors: Lassale Camille , Gaye Bamba , Diop Ibrahima Bara , Mipinda Jean Bruno , Kramoh Kouadio Euloge , Kouam Kouam Charles , Ikama Méo Stéphane , Takombe Jean Laurent , Damorou Jean Marie , Toure Ibrahim Ali , Balde Dadhi M , Dzudie Anastase , Houenassi Martin , Kane Abdoul , Kimbally-Kaki Suzy Gisèle , Kingue Samuel , Limbole Emmanuel , Mfeukeu Kuate Liliane , Ferreira Beatriz , Nhavoto Carol , Sidy Ali Abdallahi , Azizi Michel , N'Guetta Roland , Antignac Marie , Jouven Xavier 
Published: June 2022

BackgroundUse of traditional medicine (TM) is widespread in sub-Saharan Africa as a treatment option for a wide range of disease. We aimed to describe main characteristics of TM users and estimate the association of TM use with control of hypertension.MethodsWe used data on 2128 hypertensive patients of a cross-sectional study (convenience sampling), who attended cardiology departments of 12 sub-Saharan African countries (Benin, Cameroon, Congo, Democratic Republic of the Congo, Gabon, Guinea, Côte d’Ivoire, Mauritania, Mozambique, Niger, Senegal, Togo). To model association of TM use with odds of uncontrolled, severe and complicated hypertension, we used multivariable mixed logistic regressions, and to model the association with blood pressure (systolic (SBP) and diastolic (DBP)) we used mixed linear models. All models were adjusted for age, sex, wealth, adherence to hypertension conventional treatment and country (random effect).ResultsA total of 512 (24%) participants reported using TM, varying across countries from 10% in the Congo to 48% in Guinea. TM users were more likely to be men, living in rural area, poorly adhere to prescribed medication (frequently due to its cost). Use of TM was associated with a 3.87 (95% CI 1.52 to 6.22)/1.75 (0.34 to 3.16) mm Hg higher SBP/DBP compared with no use; and with greater odds of severe hypertension (OR=1.34; 95% CI 1.04 to 1.74) and of any hypertension complication (OR=1.27; 95% CI 1.01 to 1.60), mainly driven by renal complication (OR=1.57; 95% CI 1.07 to 2.29) after adjustment for measured confounders.ConclusionsThe use of TM was associated with higher blood pressure, more severe hypertension and more complications in Sub-Saharan African countries. The widespread use of TM needs to be acknowledged and worked out to integrate TM safely within the conventional healthcare.
Changes in household food security, access to health services and income in northern Lao PDR during the COVID-19 pandemic: a cross-sectional survey
Authors: Head Jennifer R , Chanthavilay Phetsavanh , Catton Helen , Vongsitthi Ammaline , Khamphouxay Kelley , Simphaly Niphone 
Published: June 2022

ObjectivesWe assessed the relative difficulty in meeting food needs during the COVID-19 pandemic compared with before; determined the relationship between pandemic-associated difficulties in food access and household, maternal and child food security; and identified resiliency-promoting strategies.DesignA cross-sectional survey of households undertaken in November 2020.SettingRural districts of Luang Prabang Province, Lao People’s Democratic Republic.ParticipantsHouseholds (N=1122) with children under 5 years.Primary and secondary outcomes measuredSurvey respondents reported the relative ease of access of food and healthcare as well as changes in income and expenditures compared with before March 2020. We determined indicators of food security and source of foods consumed for households, women and children, as well as prevalence of malnutrition in children under 5.ResultsNearly four-fifths (78.5%) found it harder to meet household food needs during the pandemic. The most common reasons were increased food prices (51.2%), loss of income (45.3%) and decreased food availability (36.6%). Adjusting for demographics, households with increased difficulty meeting food needs had lower food consumption scores and child dietary diversity. Over 85% of households lost income during the pandemic. Decreased expenditures was associated with reliance on more extreme coping strategies to meet food needs. The households who experienced no change in meeting food needs produced a greater percentage of their food from homegrown methods (4.22% more, 95% CI 1.28 to 7.15), than households who found it more difficult.ConclusionsPandemic-associated shocks may have large effects on food insecurity. Action is needed to mitigate consequences of the pandemic on nutrition. Local food production and safety net programmes that offset income losses may help.
A LASSO-derived clinical score to predict severe acute kidney injury in the cardiac surgery recovery unit: a large retrospective cohort study using the MIMIC database
Authors: Huang Tucheng , He Wanbing , Xie Yong , Lv Wenyu , Li Yuewei , Li Hongwei , Huang Jingjing , Huang Jieping , Chen Yangxin , Guo Qi , Wang Jingfeng 
Published: June 2022

ObjectivesWe aimed to develop an effective tool for predicting severe acute kidney injury (AKI) in patients admitted to the cardiac surgery recovery unit (CSRU).DesignA retrospective cohort study.SettingData were extracted from the Medical Information Mart for Intensive Care (MIMIC)-III database, consisting of critically ill participants between 2001 and 2012 in the USA.ParticipantsA total of 6271 patients admitted to the CSRU were enrolled from the MIMIC-III database.Primary and secondary outcomeStages 2–3 AKI.ResultAs identified by least absolute shrinkage and selection operator (LASSO) and logistic regression, risk factors for AKI included age, sex, weight, respiratory rate, systolic blood pressure, diastolic blood pressure, central venous pressure, urine output, partial pressure of oxygen, sedative use, furosemide use, atrial fibrillation, congestive heart failure and left heart catheterisation, all of which were used to establish a clinical score. The areas under the receiver operating characteristic curve of the model were 0.779 (95% CI: 0.766 to 0.793) for the primary cohort and 0.778 (95% CI: 0.757 to 0.799) for the validation cohort. The calibration curves showed good agreement between the predictions and observations. Decision curve analysis demonstrated that the model could achieve a net benefit.ConclusionA clinical score built by using LASSO regression and logistic regression to screen multiple clinical risk factors was established to estimate the probability of severe AKI in CSRU patients. This may be an intuitive and practical tool for severe AKI prediction in the CSRU.
Multimorbidity as assessed by reporting of multiple causes of death: variations by period, sociodemographic characteristics and place of death among older decedents in England and Wales, 2001–2017
Authors: Grundy Emily Marjatta , Stuchbury Rachel 
Published: June 2022

BackgroundMultimorbidity is common at older ages and is associated with disability, frailty and poor quality of life. Research using clinical databases and surveys has shown associations between multimorbidity and indicators of social disadvantage. Use of multiple coded death registration data has been proposed as an additional source which may also provide insights into quality of death certification.MethodsWe investigate trends in reporting multiple causes of death during 2001–2017 among decedents aged 65 years and over included in a census-based sample of 1% of the England and Wales population (Office for National Statistics Longitudinal Study). Using Poisson regression analysis, we analyse variations in number of mentions of causes of death recorded by time period, place of death, age, sex and marital status at death and indicators of health status and individual and area socioeconomic disadvantage reported at the census prior to death.ResultsNumber of mentions of causes recorded at death registration increased 2001–2017, increased with age, peaking among decedents aged 85–9 years, and was positively associated with indicators of prior disadvantage and poor health, although effects were small. Number of mentions was highest for hospital decedents and similar for those dying in care homes or their own homes.ConclusionSocioeconomic disadvantage, prior poor health, dying in hospital and older age—although not extreme old age—are associated with dying with more recorded conditions. Results may reflect both differences in multimorbidity at death and variations in quality of medical certification of death. Quality of death certification for decedents in care homes needs further investigation.
FSIP2plays a role in the acrosome development during spermiogenesis
Authors: Zheng Rui , Wang Yan , Li Yaqian , Guo Juncen , Wen Yuting , Jiang Chuan , Yang Yihong , Shen Ying 
Published: June 2022

BackgroundLoss-of-function mutations inFSIP2result in multiple morphological abnormalities of the flagella in humans and mice. Intriguingly, a recent study found that FSIP2 might regulate the expression of acrosomal proteins, indicating thatFsip2might be involved in acrosome development in mice. However, whetherFSIP2also function in acrosome biogenesis in humans is largely unknown, and the underlying mechanism of which is unexplored.ObjectiveOur objective was to reveal potential function of FSIP2 in regulating sperm acrosome formation.MethodsWe performed whole exome sequencing on four asthenoteratozoospermic patients. Western blot analysis and immunofluorescence staining were conducted to assess the protein expression of FSIP2. Proteomics approach, liquid chromatography-tandem mass spectrometry and co-immunoprecipitation were implemented to clarify the molecules in acrosome biogenesis regulated by FSIP2.ResultsBiallelicFSIP2variants were identified in four asthenoteratozoospermic individuals. The protein expression of MUT-FSIP2was sharply decreased or absent in vitro or in vivo. Interestingly, aside from the sperm flagellar defects, the acrosomal hypoplasia was detected in numerous sperm from the four patients. FSIP2 co-localised with peanut agglutinin in the acrosome during spermatogenesis. Moreover, FSIP2 interacted with proteins (DPY19L2, SPACA1, HSP90B1, KIAA1210, HSPA2 and CLTC) involved in acrosome biogenesis. In addition, spermatozoa from patients carryingFSIP2mutations showed downregulated expression of DPY19L2, ZPBP, SPACA1, CCDC62, CCIN, SPINK2 and CSNK2A2.ConclusionOur findings unveil thatFSIP2might involve in sperm acrosome development, and consequently, its mutations might contribute to globozoospermia or acrosomal aplasia. We meanwhile first uncover the potential molecular mechanism of FSIP2 regulating acrosome biogenesis.
Characterising ALS disease progression according to El Escorial and Gold Coast criteria
Authors: de Jongh Adriaan D , Braun Nathalie , Weber Markus , van Es Michael A , Masrori Pegah , Veldink Jan H , van Damme Philip , van den Berg Leonard H , van Eijk Ruben P A 
Published: June 2022

BackgroundThe Gold Coast criteria (GCC) have been proposed as a means of selecting patients for amyotrophic lateral sclerosis (ALS) clinical trials. We aimed to characterise disease progression according to the GCC.MethodsData from population-based ALS registries from the Netherlands and Belgium were analysed. The GCC additionally define ALS as lower motor neuron (LMN) dysfunction in ≥2 body regions without upper motor neuron dysfunction. Therefore, the revised El Escorial criteria (rEEC) were supplemented with a ‘Gold Coast ALS’ category for patients with only LMN dysfunction in ≥2 body regions. We assessed survival time, ALS Functional Rating Scale (ALSFRS-R) progression rates and between-patient variability per diagnostic category.ResultsWe included 5957 ALS patients, of whom 600 (10.1%) fulfilled the GCC but not the rEEC, and 95 (1.6%) fulfilled only the rEEC. ALSFRS-R progression rates were similar for the rEEC (0.84 points/month) and GCC (0.81 points/month) with similar variability (standard deviation of 0.59 vs. 0.60) and median survival time (17.8 vs.18.7 months). Survival time and average progression rates varied (p<0.001) between categories. Per category, however, there was considerable between-patient variability with progression rates ranging from: −2.10 to −0.14 (definite), −1.94 to −0.06 (probable), −2.10 to −0.02 (probable laboratory supported), −1.79 to −0.02 (possible) and −1.31 to 0.08 (Gold Coast).ConclusionsThe GCC broaden the definition of ALS, allowing more patients to participate in trials, while minimally impacting population heterogeneity. Given the large variability per diagnostic category, selecting only specific categories for trials may not result in a more homogeneous study population.
Thrombosis origin identification of cardioembolism and large artery atherosclerosis by distinct metabolites
Authors: Li Wei , Bai Xuesong , Hao Jiheng , Xu Xin , Lin Feng , Jiang Qunlong , Ding Chunguang , Dai Gaolei , Peng Fangda , Zhang Meng , Feng Yao , Wang Jiyue , Chen Xianyang , Xue Teng , Guo Xiaofan , Fu Zhaolin , Chen Wen-huo , Zhang Liyong , Wang Chaodong , Jiao Liqun 
Published: June 2022

BackgroundThe diagnosis of cerebral thrombosis origin is challenging and remains unclear. This study aims to identify thrombosis due to cardioembolism (CE) and large artery atherosclerosis (LAA) from a new perspective of distinct metabolites.MethodsDistinct metabolites between 26 CE and 22 LAA origin thrombi, which were extracted after successful mechanical thrombectomy in patients with acute ischemic stroke in the anterior circulation, were analyzed with a ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) system. Enriched metabolic pathways related to the metabolites were identified. Least absolute shrinkage selection operator regression analyses and a filtering method were used to select potential predictors. Furthermore, four machine learning classifiers, including decision tree, logistic regression, random forest (RF), and k means unsupervised classification model, were used to evaluate the predictive ability of the selected metabolites.ResultsUPLC-QTOF-MS analysis revealed that levels of 88 and 55 metabolites were elevated in LAA and CE thrombi, respectively. Kyoto Encyclopedia of Genes and Genomes analysis revealed a significant difference between the pathways enriched in the two types of thrombi. Six metabolites (diglyceride (DG, 18:3/24:0), DG (22:0/24:0), phytosphingosine, galabiosylceramide (18:1/24:1), triglyceride (15:0/16:1/o–18:0), and glucosylceramide (18:1/24:0)) were finally selected to build a predictive model. The predictive RF model was confirmed to be the best, with a satisfactory stability and prediction capacity (area under the curve=0.889).ConclusionsSix metabolites as potential predictors for distinguishing between cerebral thrombi of CE and LAA origin were identified. The results are useful for understanding the pathogenesis and for secondary stroke prevention.
Pulmonary hypertension in patients with pneumoconiosis with progressive massive fibrosis
Authors: Yu Shiwen , Wang Yiran , Fan Yali , Ma Ruimin , Wang Yuanying , Ye Qiao 
Published: June 2022

ObjectivesThis study aims to explore the prevalence and clinical features of pulmonary hypertension (PH) in patients with progressive massive fibrosis (PMF) and its correlation with large opacities on CT scans.MethodsThis retrospective study collected 235 patients with PMF, and 199 were eligible for analysis. The probability of PH development was estimated based on tricuspid regurgitation velocity measured by echocardiogram. The size and the location of large opacities on chest CT were recorded. Potential risk factors for PH secondary to PMF were analysed using regression analysis.ResultsThe prevalence of a high or intermediate probability of PH was 39.7% in patients with PMF. Type C of large opacities (OR 6.99, 95% CI 2.34 to 23.00, p<0.001) and central type of the large opacities (OR 8.12, 95% CI 2.89 to 24.71, p<0.001) were identified as the risk factors for PH secondary to PMF. Over a median follow-up of 32.8 months, the survival rate was 73.3% in the PH group, significantly lower than that in the non-PH group (96.6%, p<0.001).ConclusionsOver one-third of patients with PMF developed PH. The increased size and the central distribution of large opacities were identified as the risk factors.
Russia-Ukraine conflict and COVID-19: a double burden for Ukraine's healthcare system and a concern for global citizens
Authors: Uwishema Olivier , Sujanamulk Bhavana , Abbass Mortada , Fawaz Rabih , Javed Amaan , Aboudib Khaled , Mahmoud Ashraf , Oluyemisi Adekunbi , Onyeaka Helen 
Published: June 2022

AbstractThe conflict between Ukraine and Russia significantly influences the healthcare sector. The ongoing COVID-19 pandemic and the armed conflict have badly devastated the established healthcare system. Only 36.08% of the Ukrainian population has received the COVID-19 vaccination, with the majority receiving two doses, and currently, Ukraine records the highest mortality rate in the world. In addition to the conflict injuries, increased susceptible deaths to COVID-19 can be found due to inadequate vaccination rates for the disease. To save their lives and for their well-being, many individuals have been relocating to the underground metro stations, other cities, nearby towns and countries. In these settings, social distancing, hand sanitation and wearing masks are not prioritised. In the current circumstances, the broken healthcare system needs to be rebuilt, and the Non-Governmental Organizations (NGOs), doctors and all the front-line workers should extend their humanitarian support to the Ukrainian population. Conclusion: It is an arduous task for healthcare organisations to supply vaccines and medicines in this ‘armed conflict’ between Russia and Ukraine. This can only happen when both parties extend their support to rebuild the shattered healthcare infrastructure.
Quantitative assessment of a pediatric nociception monitor in children under sevoflurane anesthesia
Authors: Lebrun Sebastien , Boccara Johanna , Cailliau Emeline , Herbet Mathilde , Tavernier Benoit , Constant Isabelle , Sabourdin Nada 
Published: June 2022

IntroductionIntraoperative monitoring of nociception has recently made substantial progress in adult anesthesia. In contrast, pediatric data are scarce. Newborn-Infant Parasympathetic Evaluation (NIPE index, Mdoloris Medical Systems, Loos, France) is the first nociception index specifically designed for young children. It is a dimensionless index comprised between 0 and 100. Two previous studies suggested that NIPE could indeed ‘detect’ nociception in anesthetized children. The objective of our study was to investigate if NIPE allowed to detect and to provide a quantitative assessment of nociception in children.MethodsChildren were anesthetized with sevoflurane, and received a bolus of alfentanil (10 µg/kg before intubation). Before surgical incision, each participant received three tetanic stimulations (5 s, 100 Hertz) with a 5 min interval, in a randomized order: 10, 30 and 60 milliamps. NIPE and heart rate variations were assessed after each stimulation.ResultsThirty children (2.4±1.6 years) were included. Mean delay between alfentanil and the first stimulation was 19±4 min. Mean baseline NIPE was 75±10. NIPE variation after the stimulations was significant at 10, 30 and 60 mA (linear mixed regression model, p<0.001). The intensity of stimulation significantly influenced the amplitude of NIPE variation (linear mixed regression model p<0.001), but had no statistically significant effect on heart rate variation (p=0.52).DiscussionNIPE might allow a quantitative assessment of nociception in young children in these anesthetic conditions. This study provides a basis for future research investigating the potential benefits of NIPE-guided intraoperative analgesia in pediatric anesthesia.Trial registration numberNCT04381637.