bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on finite time stability of lower limb rehabilitation exoskeleton based on compliance control
Authors: Liu Keping , Li Li , Li Wanting , Gu Jian , Liu Shuaishi , Sun Zhongbo 
Published: October 2022

Abstract
In this paper, in order to achieve safe, stable and efficient lower limb rehabilitation training, a PRR-NTSMIC(power reaching rate-nonsingular terminal sliding mode impedance controller, PRR-NTSMIC) for lower limb rehabilitation exoskeleton robot is proposed. Firstly, the kinemat-ics and dynamics models of the lower limb rehabilitation exoskeleton robot are established. On the basis of the model, PRR-NTSMIC is illustrated to ensure the compliance, comfort and robustness of the lower limb rehabilitation exoskeleton robot in the process of rehabilitation training, and the FTS(finite-time stability,FTS) of the system is verified by Lyapunov. Secondly, the superiority of the proposed control scheme is illustrated by designing a comparative simulation with the traditional PRR-SMIC(power reaching rate-sliding mode impedance controller, PRR-SMIC) and PRR-TSMIC(power reaching rate-terminal sliding mode impedance controller, PRR-TSMIC) algorithms. Then, in order to obtain better controller performance, through analyzing the influence of parameters values on control effect, numerical comparison simulations are designed to select the optimal controller 1 Springer Nature 2021 L A T E X template Article Title parameters values. Finally, the human bicycle motion data are collected as the system input for bicycle rehabilitation training based on lower limb rehabilitation exoskeleton robot to verify the proposed control method. The experimental results illustrate that the proposed controller has high tracking accuracy, effectiveness, robustness and FTS.
Insecticidal bioactive compounds derived from Cladosporium cladosporioides (Fresen.) G.A. de Vries and Acremonium zeylanicum (Petch) W. Gams &amp; H.C. Evans
Authors: Mousavi Khaled , Rajabpour Ali , Parizipour Ghodoum , Yarahmadi Fatemeh 
Published: October 2022

Abstract
Entomopathogenic fungi (EPF) are the main microbiological control agents of insect pests. One of the key factors in the pathogenicity of EPF is the production of insecticidal bioactive compounds. Therefore, the metabolites of two isolates of EPF, Cladosporium cladosporioides (Fresen.) G.A. de Vries (AF98) and Acremonium zeylanicum (Petch) W. Gams & H.C. Evans (IR87), were analyzed. The presence of insecticidal toxic cyclic peptides such as Bassianolide in C. cladosporioides AF98 metabolites was detected by HPLC. Moreover, GC-MS analysis showed some toxic compounds, including 3,4-Dihydro-7,12-Dihydroxy-7,12-Imethylbenz[A]Anthracene, 1,2,3,4-Tetrahydro-1,1,4,4,6-Pentamethyl-5,7-Dinitronaphthalene, and 1,2,3,4-Tetrahydro-1,1,4,4,6-Pentamethyl-5,7-Dinitronaphthalene in the metabolites purified from A. zeylanicum IR87. Also, a few hazardous compounds, including 3,5-di-tert-butyl-4-trimethylsiloxytoluene, bis(2-Ethylhexyl) phthalate, di-n-octyl phthalate, 1-pentadecene, and 1-eicosene were found which might be toxic against insects. These results showed that multiple compounds are likely contributed to the insecticidal effects of the EPF.
SARS-CoV-2 Spike receptor-binding domain entrapped in mannose-conjugated chitosan nanoparticle vaccine delivered intranasal elicits local and systemic Th1 and Th2 immune responses in mice and antiviral efficacy in Syrian hamsters
Authors: Tabynov Kairat , Solomadin Maxim , Turebekov Nurkeldi , Babayeva Meruert , Fomin Gleb , Yadagiri Ganesh , Sankar Renu , Yerubayev Toktassyn , Yespolov Tlektes , Petrovsky Nikolai , Renukaradhya Gourapura J , Tabynov Kaissar 
Published: October 2022

Abstract
Given the ongoing COVID-19 pandemic and the need to build sustainable herd immunity in the population, the search for novel and safe vaccines for easy mass vaccination is an urgent task. We developed a novel intranasal subunit vaccine called NARUVAX-C19/Nano which is based on the SARS-CoV-2 spike protein receptor-binding domain (RBD) entrapped in mannose-conjugated chitosan nanoparticles (NP). To potentiate the cell mediated cell immune responses by the NP-vaccine formulation included the adjuvant CpG55.2, a toll-like receptor 9 agonist. The vaccine candidates administered intranasal were assessed for immunogenicity, protective efficacy, and virus transmission from vaccinates in inmates. The results were compared with a soluble RBD mixed with alum adjuvant vaccine administered intramuscular. In BALB/c mice administered with both the NP vaccines intranasal twice induced secretory IgA antibodies and pronounced Th1-cell responses, that was absent in intramuscular alum-adjuvanted RBD vaccine group. In Syrian hamsters delivered with similar NP formulations provided protection against a wild-type SARS-CoV-2 (D614G) challenge infection, indicated by significantly rescue in weight loss, reduced viral load in respiratory organs and lung pathology. However, despite significantly reduced viral load in the nasal turbinates and oropharyngeal swabs in NP vaccinated hamsters the virus transmission to naïve sentinel animals could not be blocked. In conclusion, intranasal delivered RBD-based NP vaccine formulations induced mucosal immune responses in mice and protected Syrian hamsters against SARS-CoV-2 infection. These findings are encouraging and supportive for further investigations to develop an intranasal NP-based vaccine platform to mitigate SARS-CoV-2 infection.
EfficientNetV2 for Quality Estimation of Diabetic Retinopathy Images from DeepDRiD
Authors: Tummala Sudhakar 
Published: October 2022

Abstract
Diabetic retinopathy (DR) is caused by diabetes and is usually identified from retinal fundus images. Regular DR screening from digital fundus images could be burdensome to ophthalmologists and moreover prone to human errors. The quality of the fundus images is essential to improve the quality of the classification and thereby reduce diagnostic errors. Hence an automated method for quality estimation (QE) of digital fundus images using an ensemble of EfficientNetV2 models including small, medium, and large models is proposed. The ensemble method was cross-validated and tested on an openly available dataset from DeepDRiD. The test accuracy for QE is 75% outperforming the existing methods on the DeepDRiD dataset. Hence, this may be a potential tool for automated QE of fundus images and could be handy to the ophthalmologist.
Effects of drought stress and rehydration on physiological and biochemical of four oak species in China
Authors: Xiong Shifa , Wang Yangdong , Chen Yicun , Gao Ming , Zhao Yunxiao , Wu Liwen 
Published: October 2022

Abstract
Background
Quercus fabri Hance, Quercus serrata Thunb, Quercus acutissima Carruth, and Quercus variabilis BL are four Chinese oak species commonly used for forestation. With the global warming caused by the greenhouse effect, seedlings in mountainous areas after afforestation often suffer seasonal drought stress, which seriously affects their survival and growth. In order to ensure the survival of seedlings, we need to select oak species with strong drought resistance. Therefore, we first need to understand the differences in drought resistance of the four oak tree species at the seedling stage, and comprehensively evaluate their drought resistance capabilities by studying the changes in the physiological and biochemical characteristics of the seedlings under continuous drought and rehydration conditions.
Results
Compared with the control group, the relative water content, water potential, net photosynthetic rate, transpiration rate, and stomatal conductance levels of the four oaks all showed a downward trend under continuous drought stress, and showed an upward trend after rehydration. The soluble protein, soluble sugar, proline, peroxidase, superoxide dismutase and catalase content of the four oaks increased first and then decreased under drought stress, and then increased after rehydration. The content of glycine betaine and malondialdehyde continued to increase, and gradually decreased after rehydration.
Conclusions
The weight of each index was calculated by PCA, and then the comprehensive evaluation of each index was carried out through the membership function method. The drought resistance levels of the four oak species were as follows: Q. serrata > Q. fabri > Q. variabilis > Q. acutissima.
Numerical simulation of hydrodynamic lubrication phenomenon in thrust bearing with cavitation
Authors: Chen Hao , Chen Yu , Wang Xiuying , Wang Hongchang , Sun Yu 
Published: October 2022

Abstract
A mixed computational model is presented to evaluate the hydrodynamic lubrication phenomenon of spiral grooved thrust bearing (SGTB). With cavitation effects taken into account, this model is developed with a high-level capability for describing the hydrodynamic lubrication phenomenon of SGTB. For design parameter and operation condition, the model includes the influence of lubricated medium, shear rate and lubricant layer, which could ensure the computational accuracy. Meanwhile, the correctness and effectiveness of simulation model are demonstrated by the published experiment data. In addition, the lubrication characteristics of SGTB reveal the correlation property between design parameters and hydrodynamic response.
Organoid Models of Heart Diseases: Find a New Channel in Improvements
of Cardiac Regenerative Medicine
Authors: Jasim Saade Abdalkareem , Bokov Dmitry Olegovich , Suksatan Wanich , Alsaikhan Fahad , Jawad Mohammed Abed , Sharma Satish Kumar , Chupradit Supat , Thangavelu Lakshmi 
Published: October 2022

Abstract:
We are experiencing a revolution in regenerative medicine. Recent developments
in organoid technology have provided unique opportunities for studying human biology
and diseases. Indeed, organoid models have revolutionized the in vitro culture
tools for biomedical research by creating robust three-dimensional (3D) architecture to recapitulate
the primary tissues' cellular heterogeneity, structure, and functions. Such
organoid technology enables researchers to re-create human organs and diseases model
in a culture dish. It thus holds excellent promises for many translational applications such
as regenerative medicine, drug discovery, and precision medicine. This review summarizes
the current knowledge on the progression and promotion of organoid models,
particularly with the heart disease approach. We discuss the usefulness of clinical applications
of cardiac organoids and ultimately highlight the currently advanced therapeutic
strategies in vitro model of organoids aimed at personalizing heart disease treatment.
Advancements in Anaphylaxis Management
Authors: Alvarez-Perea Alberto , Cabrera-Freitag Paula , Fuentes-Aparicio Victoria , Infante Sonsoles 
Published: October 2022

Abstract:
Anaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction. Yet, anaphylaxis is often difficult to diagnose, which in turn leads to a delay in the application of appropriate management. Epinephrine is the medication of choice for the immediate treatment of anaphylaxis. The rest of the actions to be taken during the acute episode of anaphylaxis, including the administration of other medications, will depend on the response to epinephrine.
Epinephrine auto-injectors (EAI) are the preferred method for administration of treatment of anaphylaxis in the community setting. However, there are multiple potential barriers for the use of epinephrine during an anaphylactic reaction, related to the physicians and the patients themselves. Strategies to overcome gaps in the acute management of anaphylaxis include novel injection devices and research of new routes for the delivery of epinephrine. Electronic health solutions may also have a role at this level.
Long-term management of anaphylaxis is focused on the prevention of new episodes. Etiologic diagnosis and patient education are key to this end. Application of health information technologies, such as telemedicine, social media, and mobile health can be helpful for the long-term management of anaphylaxis.
Additionally, some patients may benefit from long-term immunomodulatory and etiologic treatments when allergen avoidance implies negative consequences.
The aim of this review article is to address the most recent advances regarding the integral management of anaphylaxis, including pharmacological and non-pharmacological measures.
Impact of “Long Covid” on Children: Global and Hong Kong Perspectives
Authors: Hon Kam Lun Ellis , Leung Alexander K.C. , Leung Karen Ka Yan , Wong Alex H.C. 
Published: October 2022

Background:
The coronavirus disease (COVID-19) pandemic spares no nation or city, and the virus is responsible for the escalating incidence and mortality all around the world.

Objective:
This article reviews the impact of “Long Covid” on Children.

Methods:
A PubMed search was conducted in December 2021 in Clinical Queries using the key terms "COVID-19" OR “long COVID”. The search was restricted to children and adolescent aged < 18 years, and English literature.

Results:
Many large-scale studies have provided strong scientific evidence as to the detrimental and irreversible sequelae of COVID-19 on the health, psychology, and development of affected children. Many insights to the management of this disease can be obtained from comparing the management of influenza disease. COVID-19 is generally a mild respiratory disease in children. Several syndromes such as multisystem inflammatory syndrome in children (MIS-C) and COVID toe are coined but are probably not specific to SARS-CoV-2. “Long COVID” or the long-term effects of SARS-CoV-2 infection, or the prolonged isolation and containment strategies on education and psychosocial influences on children associated with the pandemic, are significant.

Conclusions:
Healthcare providers must be aware of the potential effects of quarantine on children's mental health. More importantly, health care provides must appreciate the importance of the decisions and actions made by governments, non-governmental organizations, the community, schools, and parents in reducing the possible effects of this situation. Multifaceted age-specific and developmentally appropriate strategies must be adopted by health care authorities to lessen the negative impact of quarantine on the psychological wellbeing of children.
Frontline Management of Advanced Epithelial Ovarian Cancer: A
Comprehensive Statement by the Africa Middle East Cancer Inter-group
[AMCI]
Authors: Seoud Mudieddine , Ladjeroud Amel , Jaafar Hassan , Mokhtar Mohsen , Ozyilkan Ozgur , Alkhayyat Shadi , Dawood Shaheenah , Arik Zafer , Azim Hamdy A. 
Published: October 2022

Abstract:
Worldwide, ovarian cancer (OC) is one of the leading causes of cancer-related death among women. Despite the recent progress in the treatment of advanced OC, oncologists in many parts of the world still face several difficulties and constraints in their daily management of their patients. In addition to the shortage of resources and expertise, non-adherence to the up to date international guidelines has been identified as a major obstacle towards the improvement of treatment outcomes in the majority of developing countries, including the Middle East and North African (MENA) countries. A multidisciplinary gynecological oncology panel from the MENA region met virtually in December 2020 to discuss the challenges and hurdles faced by the community oncologists in the management of advanced OC. This manuscript reviews the key molecular and clinical studies that shaped the current international guidelines and suggests several modifications to make them more adaptable to the health status of developing countries of this region
Web-based Guidance for Assisted Reproductive Technology With an Online App (myFertiCare): Quantitative Evaluation With the HOT-fit Framework
Authors: Sparidaens Ellen Marie , Logger Jade G M , Nelen Willianne L D M , Braat Didi D M , Fleischer Kathrin , Hermens Rosella P M 
Published: October 2022

Background
Assisted reproductive technologies (ARTs) are considered to be physically and mentally stressful. During their treatment trajectory, couples express high information and communication needs. They appreciate using the internet to obtain fertility-related information. In a previous study, we developed myFertiCare, an eHealth tool providing personalized information and interactive functionalities for infertile couples in order to improve patient-centered care. The app has already been successful in qualitative evaluations of usability.

Objective
The aim of the current study is to quantitatively evaluate the implementation of myFertiCare by using the human, organizational, and technology–fit (HOT-fit) framework and to study the effects of using myFertiCare on couples’ knowledge about infertility, their experience of the burden of infertility, and their experience of patient-centered care. With these results, implementation can be further improved, and patient-centered care can be enhanced.

Methods
A quantitative study was performed based on the HOT-fit framework using validated questionnaires focusing on the human, organizational, and technology domains. Questions were added on the effect of using myFertiCare on couples’ knowledge about infertility and treatment. Questions regarding the burden of infertility, the burden of infertility treatment, and the experience of patient-centeredness were based on the main items of the validated fertility quality of life (FertiQoL) and Patient-Centredness Questionnaire–Infertility questionnaires, respectively. Also, nonusers of the app were included to explore motivations for not using the app and identify opportunities for improvement. Finally, user data were analyzed to provide insight into multiple variables concerning app use.

Results
In the human and technology domains, myFertiCare showed good system usability, high user satisfaction, and high information and interface quality. In the organizational domain, implementation was considered to be sufficient by both patients and staff. Use of the app increased knowledge about the treatment, improved coping with the treatment, and enhanced the experience of patient-centeredness. User data showed that women were the main app users and that use of the app gradually declined during the treatment trajectory.

Conclusions
A multi-faceted online app, myFertiCare, has been successfully evaluated quantitatively for implementation by using the HOT-fit framework. Use of the app increased knowledge about the treatment, improved coping with the treatment, and enhanced the experience of patient-centeredness. App use could be improved by creating more publicity. By providing myFertiCare, professionals in fertility care are supported in guiding patients through their treatment trajectory and in delivering patient-centered care.
Pengembangan sistem kewaspadaan dini penyakit new-emerging dan re-emerging, studi kasus pada penyakit mers-cov dan ebola di kantor kesehatan pelabuhan soekarno-hatta
Authors: AK Ike Yuliani Dewi 
Published: October 2022

Latar Belakang: Penyakit menular tetap menjadi salah satu penyebab utama kematian di seluruh dunia karena tiga alasan: 1) munculnya penyakit menular baru (new-emerging disease); 2) munculnya kembali penyakit menular lama (re-emerging disease); dan 3) menetapnya penyakit yang tidak dapat terselesaikan. Salah satu yang mempengaruhi penyakit infeksi new-emerging dan re-emerging adalah meningkatnya mobilitas penduduk antar negara melalui travel internasional yang semakin mudah. KKP Soekarno-Hatta memiliki tugas pokok cegah tangkal penyakit, yaitu mencegah penyakit menular ke luar dan menangkal penyakit masuk ke Indonesia melalui pintu masuk negara yaitu Bandar Udara Soekarno-Hatta. Untuk meningkatkan kewaspadaan dini pada penyakit infeksi new-emerging dan re-emerging, khususnya penyakit Mers-CoV dan Ebola, maka diperlukan suatu alat yang dapat membantu Dinas Kesehatan dalam melakukan pemantauan pada dengan perjalanan dari dan keluar negri.Tujuan: Penelitian ini bertujuan untuk melakukan pengembangan terhadap sistem kewaspadaan dini penyakit New-Emerging dan Re-Emerging dengan berfokus pada kasus penyakit Mers-Cov dan Ebola di kantor Kesehatan Pelabuhan Soekarno-Hatta.Metode: Penelitian ini merupakan penelitian kualitatif, data diperoleh melalui tehnik tehnik wawancara, studi literatur dan observasi lapangan. Metode yang digunakan dalam pengembangan sistem ialah System Development Life Cycle (SDLC) Waterfal.Hasil: Data hasil wawancara, observasi, dan analisis dokumen diperoleh sistem informasi yang dimiliki KKP Soekarno-Hatta sudah memadai namun tidak didukung dengan kelengkapan software pencatatan pada setiap computer, petugas KKP juga masih melakukan pencatatan manual, sehingga berdampak pada keterbatasan mengakses data, waktu pengolahan data, dan keterlambatan pada pelaporan data. Sistem kewaspadaan dini didesign menghasilkan laporan airline serta laporan kunjungan pasien secara otomatis. Untuk menjamin keamanan sistem dibatasi 20 menit pada waktu entry, dilengkapi username dan password. Pada proses pengujian system menggunakan Blackbox Testing. Kesimpulan: Prototype sistem kewaspadaan dini penyakit infeksi new-emerging dan re-emerging masih perlu dilakukan sosialisasi terutama terkait penggunaannya. Kata Kunci: sistem kewaspadaan dini, mers-cov, ebola
Analisis Tingkat Mortalitas pada Laporan Tahunan di Rumah Sakit Katolik Budi Rahayu Blitar
Authors: Anggryani Femy 
Published: October 2022

Latar belakang: Rekam medis merupakan sumber data bagi rumah sakit yang dapat diolah menjadi statistik. Statistik mortalitas termasuk dalam statistik pelayanan kesehatan yang bermanfaat dalam upaya penjagaan mutu rumah sakit. Tujuan penelitian ini yaitu mengetahui gambaran statistik tingkat mortalitas di Rumah Sakit Katolik Budi Rahayu Blitar beserta trend angka kematiannya sekaligus perkiraan (forecasting) angka kematian pada tahun 2021 dan 2022 Metode: Penelitian deskriptif kuantitatif dengan metode survei merupakan jenis penelitian ini. Data diperoleh melalui observasi dan kuesioner. Hasil: Trend MDR, PODR, dan ADR mendatar selama 2017-2019. Trend FDR meningkat selama 2017-2019. Prediksi nilai GDR tahun 2021 sebesar 55,34‰ dan tahun 2022 sebesar 48,8‰. Prediksi nilai NDR tahun 2021 sebesar 18,3‰ dan tahun 2022 sebesar 11,33‰. Prediksi nilai MDR tahun 2021 dan 2022 sebesar 0,13%. Prediksi nilai NMR tahun 2021 sebesar 0,19% dan tahun 2022 sebesar 0%. Kesimpulan: Prediksi indikator mortalitas menunjukkan GDR dan FDR belum memenuhi standar ideal, sedangkan NDR, MDR, NMR, PODR, dan ADR sudah memenuhi standar ideal. Sebaiknya pihak rumah sakit melakukan evaluasi atau audit medis terhadap indikator yang melebihi standar dan terus meningkatkan kinerja pelayanan agar indikator selalu mencapai standar ideal.