bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in median eminence of fatty acid–binding protein 3 in a mouse model of pain
Authors: Tachibana Dan , Nakamoto Kazuo , Tokuyama Shogo 
Published: January 2022

AbstractAimsFatty acid–binding protein (FABP) regulates polyunsaturated fatty acid (PUFA) intracellular trafficking and signal transduction. Our previous studies demonstrated that the alteration of PUFA in the hypothalamus is involved in pain process. However, how FABP subtypes change during pain remain unclear. Here, we examined the expression changes and localization in the hypothalamic FABP subtype in postoperative pain model mice.MethodsPaw incision–induced postoperative methods were adopted as a pain model in male ddY mice. Mechanical allodynia was examined using the von Frey test. The analysis of several FABPs mRNA was measured by real‐time PCR, and cellular localization of its protein level was measured by immunofluorescent study.ResultsPostoperative pain mouse elicited mechanical allodynia on Day 2 after paw incision, and mRNA expression of FABP3 increased significantly in the hypothalamus in the postoperative pain mouse model compared to that in control mice. FABP3 protein expressed in the median eminence and the arcuate nucleus, and colocalized with Iba‐1, which is a microglial cell marker. Its protein level significantly increased in the median eminence on Day 2 after incision and returned to the control level on Day 4 after incision.ConclusionsOur findings indicate that FABP3 in the median eminence may change in pain stimuli and may represent a molecular link controlling pain.
Association between idiopathic pulmonary hemosiderosis and celiac disease in pediatric patients: A scoping review of the literature over the past 50 years
Authors: Saha Biplab K , Saha Santu , Bonnier Alyssa , Saha Baidya Nath 
Published: January 2022

AbstractIntroductionIdiopathic pulmonary hemosiderosis (IPH) is a rare cause of diffuse alveolar hemorrhage, the mechanism of which is currently unknown. Nearly one‐third of pediatric patients with IPH test positive for Celiac disease (CD) serology. Several hypothetical mechanisms have been proposed to unify the coexistence of these two entities, also referred to as Lane‐Hamilton syndrome (LHS).MethodThis manuscript is a scoping review of the medical literature. Medline, Embase, and PubMed Central databases were searched between 1971 and 2021 with appropriate search words to identify all cases of pediatric LHS.ResultsA total of 20 manuscripts with 23 pediatric patients with LHS were identified. The mean age was 11 years, and 13/23 (56.5%) of the children were boys. Hemoptysis was present in 57% of patients during diagnosis. Bronchoscopy with bronchoalveolar lavage demonstrating hemosiderin laden macrophages was the primary mode of diagnostic confirmation. Only three patients underwent lung biopsy. Any significant GI symptom was reported in a minority of patients (22%). Iron deficiency anemia on presentation was described in 83% of children. The majority of patients were malnourished. Serology for CD was positive in all patients, as was the histopathologic analysis of the small bowel biopsy. No patients had any other autoantibody positivity. The introduction of gluten free diet (GFD) was associated with a positive response in 20/23 patients.ConclusionAll pediatric patients with IPH should undergo screening for CD. Low serum ferritin in patients with IPH could be suggestive of coexisting CD. Strict GFD should be tried as the initial therapy.
Chlorothalonil alters the gut microbiota and reduces the survival of immature honey bees reared in vitro
Authors: Wu Tong , Han Bo , Wang Xing , Tong Yuemin , Liu Feng , Diao Qingyun , Dai Pingli 
Published: January 2022

AbstractBACKGROUNDChlorothalonil is a nonsystemic fungicide, and it is one of the most widely detected pesticides in bee hives. The effect of chlorothalonil on the survival, weight, and gut microbiota of immature Apis mellifera L. reared in vitro was studied.RESULTSLarvae were fed 1, 2, 4, 8, and 16 μg/mL chlorothalonil and compared with larvae fed the negative control (diet without any additives), positive control (45 mg/L dimethoate), and solvent control (2% acetone). Compared with the control groups, the survival of the 2, 4, 8, and 16 μg/mL chlorothalonil treatments was significantly reduced. The no‐observed‐adverse‐effect concentration of chlorothalonil was 1 μg/mL. Chlorothalonil had no significant effect on larval weight. The gut bacterial community composition of newly emerged bees was determined by PacBio 16S rDNA gene sequencing. linear discriminant analysis effect size (LEFSe) analysis showed that Pseudomonadales and Burkholderiales were affected by exposure to chlorothalonil.CONCLUSIONChlorothalonil reduced the survival of honey bee larvae and altered the gut microbiota of newly emerged bees. The risk of pesticides to honey bees is related to their toxicity and exposure dose.
Health‐promoting and disease‐mitigating potential of Verbascum thapsus L. (common mullein): A review
Authors: Gupta Ashutosh , Atkinson Alexa N. , Pandey Abhay Kumar , Bishayee Anupam 
Published: January 2022

AbstractMedicinal plants represent rich sources of traditional medicines and numerous currently used medicines are either directly or indirectly derived from plants. Verbascum thapsus L. (great mullein or common mullein), a medicinal herb indigenous to northern Africa, western and central Asia, and Europe, has been brought to the Americas and Australia. It has been used as a medicine for lung, skin and throat disorders and has a long history of therapeutic importance, particularly as an astringent and calming agent. Presently, the dried leaves, flowers, various plant extracts and flower oil are used in several formulations within Indian traditional medicine. An extract taken from the roots is useful in minimizing toothache, and it also relieves stiffness and seizures. V. thapsus contains a wide variety of phytoconstituents, such as flavonoids, iridoid, phenylethanoid and phenylpropanoid glycosides, saponins, as well as vitamin C and minerals. The most valuable constituents are coumarin and hesperidin, which possess healing properties. Emerging literature based on experimental studies on V. thapsus demonstrates various biological and pharmacological properties, including antiviral, antioxidant, analgesic, sedative, anti‐inflammatory, hypnotic, antibacterial, antifungal, as well as anticancer activities. The present review provides an updated, comprehensive, and critical evaluation of various health‐promoting and disease‐mitigating properties of V. thapsus.
Resonant Oscillations of Josephson Current in Nb‐Bi2Te2.3Se0.7‐Nb Junctions
Authors: Stolyarov Vasily S. , Roditchev Dimitri , Gurtovoi Vladimir L. , Kozlov Sergey N. , Yakovlev Dmitriy S. , Skryabina Olga V. , Vinokur Valerii M. , Golubov Alexander A. 
Published: January 2022

AbstractJosephson proximity junctions and devices employing topological insulators are promising candidates for realizing topological superconductivity and topologically protected quantum circuits. Here, the new type of oscillations of the critical Josephson current in the ballistic Nb‐Bi2Te2.3Se0.7‐Nb junctions subject to the magnetic fields is reported. The oscillations appear below ≈400 mK and have a very unusual sharp‐peaked shape. Their ultra‐short period ≈1 Oe, by orders of magnitude shorter than the expected periodicity due to fluxoid quantization in the device, corresponds to the extremely low energy scale ≈1 eV. It is established that the observed effect is due to the resonant transmission of Andreev quasiparticles via the peculiar energy levels forming near the S‐TI interfaces.
Anti‐unwinding adaptive spacecraft attitude tracking control based on similar skew‐symmetric structures
Authors: Su Yunzhe , Yang Yajun , Yang Xuerong , Zhang Xueyang 
Published: January 2022

AbstractThis article addresses the adaptive attitude tracking control based on similar skew‐symmetric structure. Based on the structure, a novel adaptive backstepping scheme is proposed to design the attitude controller. To avoid unwinding, a rotation matrix rather than a quaternion is used to describe the attitude. Correspondingly, the application of similar skew‐symmetric structure is extended from euclidean space to noneuclidean space, for which the stability is proved by combining the Lyapunov function and the Morse–Lyapunov function. In addition, the smooth projection function is adopted to design the adaptive law for the unknown parameters. And the input‐to‐state stable property of the closed‐loop system is proved when considering the unmodeled disturbance. Finally, numerical simulations are carried out to illustrate the effectiveness of the proposed controllers.
Anti‐disturbance resilient tracking control for semi‐Markov jumping systems
Authors: Priyanka Sargunan , Sakthivel Rathinasamy , Kwon Ohmin , Mohanapriya Saminathan 
Published: January 2022

AbstractThis article investigates the output tracking problem of semi‐Markov jump systems with exogenous disturbance and generally uncertain transition probability rates. In particular, the elements in the transition rates are allowed to be known, uncertain or completely unknown. In specific, a state‐space of the modified repetitive controller is considered for tracking the given reference signals. Then, a generalized extended state observer is constructed to estimate the external disturbances and these estimates are incorporated in the control law to reject the disturbances effectively. Moreover, additive gain fluctuations are considered in the control design to tolerate gain fluctuations. First, a continuous‐discrete two‐dimensional (2D) delayed system is developed based on the lifting technique to characterize the repetitive control system's control and learning behavior. Then a sufficient condition for the bounded stability of the 2D hybrid system is obtained by choosing a suitable Lyapunov–Krasovskii functional. In addition, the control and observer gains are evaluated by solving a set of linear matrix inequalities and using the pole placement technique. At last, a robot arm model is presented to show the applicability of the proposed control scheme and a comparison study is made over some existing literature.
Photo‐Activated Nanofibrous Membrane with Self‐Rechargeable Antibacterial Function for Stubborn Infected Cutaneous Regeneration
Authors: Yang Yingming , Zhou Xiong , Chan Yau Kei , Wang Ziyou , Li Limei , Li Jiyao , Liang Kunneng , Deng Yi 
Published: January 2022

AbstractFor quick disinfection treatment, phototherapy, including photothermal therapy and photodynamic therapy, has emerged as a promising alternative to conventional methods. However, the bactericidal effect of phototherapy, which only works upon light, is short‐lived. The remaining bacteria in situ may repopulate when the irradiation of light is withdrawn. To address this refractory concern, an antibacterial fibrous membrane consisting of electrospun poly (polycaprolactone) scaffolds and polydopamine (pDA) coated MXene/Ag3PO4 bioheterojunctions (MX@AgP bio‐HJs) is devised and developed. Upon near‐infrared (NIR) illumination, the MX@AgP nanoparticle (NP) in nanofibrous electrospun membranes exert the excellent bactericidal effect of phototherapy and release Ag+ ions which stop the remaining bacteria from multiplying in the dark state. When removing NIR light, pDA in situ reduces Ag+ ions to Ag0 NPs to realize the self‐rechargeability of Ag+ ions and provides enough Ag+ ions for the second phototherapy. In vivo results show that photoactivated nanofibrous membranes can re‐shape an infected wound microenvironment to the regenerative microenvironment through killing bacteria, ceasing bleeding, increasing epithelialization, and collagen deposition on the wound bed, as well as promoting angiogenesis. As predicted, the proposal work offers potential prospects for nanofibrous membranes with NIR‐assisted “self‐rechargeable” antibacterial properties to treat bacteria‐infected full‐thickness wounds.
Bandgap Engineering in 2D Lateral Heterostructures of Transition Metal Dichalcogenides via Controlled Alloying
Authors: Nugera Florence A. , Sahoo Prasana K. , Xin Yan , Ambardar Sharad , Voronine Dmitri V. , Kim Un Jeong , Han Yoojoong , Son Hyungbin , Gutiérrez Humberto R. 
Published: January 2022

Abstract2D heterostructures made of transition metal dichalcogenides (TMD) have emerged as potential building blocks for new‐generation 2D electronics due to their interesting physical properties at the interfaces. The bandgap, work function, and optical constants are composition dependent, and the spectrum of applications can be expanded by producing alloy‐based heterostructures. Herein, the successful synthesis of monolayer and bilayer lateral heterostructures, based on ternary alloys of MoS2(1−x)Se2x–WS2(1−x)Se2x, is reported by modifying the ratio of the source precursors; the bandgaps of both materials in the heterostructure are continuously tuned in the entire range of chalcogen compositions. Raman and photoluminescence (PL) spatial maps show good intradomain composition homogeneity. Kelvin probe measurements in different heterostructures reveal composition‐dependent band alignments, which can further be affected by unintentional electronic doping during the growth. The fabrication of sequential multijunction lateral heterostructures with three layers of thickness, composed of quaternary and ternary alloys, is also reported. These results greatly expand the available tools kit for optoelectronic applications in the 2D realm.
Standards‐based modeling and deployment of serverless function orchestrations using BPMN and TOSCA
Authors: Yussupov Vladimir , Soldani Jacopo , Breitenbücher Uwe , Leymann Frank 
Published: January 2022

AbstractFunction‐as‐a‐Service (FaaS) is a cloud service model enabling to implement serverless applications for a variety of use cases. These range from scheduled calls of single functions to complex function orchestrations executed using orchestration services such as AWS step functions. However, since the available function orchestration technologies vary in functionalities, supported modeling languages, and APIs, modeling such function orchestrations and their deployment require significant technology‐specific expertise. Moreover, the resulting models are typically not portable due to provider‐ and technology‐specific details, and major efforts are required when exchanging an orchestrator or provider due to such lock‐ins. To tackle this issue, we introduce a vendor‐ and technology‐agnostic method for the modeling and deployment of serverless function orchestrations, which relies on the business process model and notation (BPMN) and topology and orchestration specification for cloud applications (TOSCA) standards for modeling function orchestrations and their deployment, respectively. We also present a toolchain for modeling serverless function orchestrations in BPMN, generating proprietary models supported by different function orchestration technologies from BPMN models, specifying their actual deployment in TOSCA, and then enacting such deployment. Finally, we illustrate a case study applying our method and toolchain in practice.
Effect of web stiffeners on lateral buckling of I‐section simply supported beam
Authors: Bui Hung Cuong , Trinh Duy Khanh , Nguyen Minh Tuyen 
Published: January 2022

AbstractVertical web stiffeners partially restrain the warping of the simply supported beam when lateral buckling occurs. The restraint increases the critical moment of the beam. This increase can be shown through the decrease of the warping effective length factor in the general formula determining the critical moment. An approximative expression to determine the warping effective length factor is proposed and verified by numerical analysis. Simply supported beams stiffened by vertical stiffeners, including end plates, which are subjected respectively to uniform bending, uniformly distributed loads, two concentrated loads and one concentrated load are numerically analyzed using COMSOL finite element software. The reliability of the proposed expression is assured by small coefficients of variation and very high coefficients of determination. It can provide a solution to improve the critical moment in the design of the beam without using an intermediate lateral bracing system.
Bending response of sandwich panels with steel skins and aluminium foam core
Authors: Latour Massimo , D'Aniello Mario , Babcsan Norbert , Capone Paolo , Landolfo Raffaele , Rizzano Gianvittorio 
Published: January 2022

AbstractNominated for Eurosteel 2021 Best Paper AwardThe introduction to the market of metal foams represents a significant opportunity to increase the use of metal in the construction market. In fact, the development of new products made of metal foams and steel could improve the performance of conventional buildings in terms of stiffness and resistance. The first structural applications of these materials have already shown the potential of composites made of foam and steel, and demonstrated the feasibility of producing mono‐dimensional and bi‐dimensional elements with a high resistance‐to‐weight ratio. Reducing the structural weight can be a significant advantage in many cases, such as infrastructures or buildings in seismic zones. Within this framework, the work presented in this paper aims to assess the response of composite sandwich panels made of steel and aluminium foam using a set of tests that will serve as the basis for developing a new system of dry‐assembled composite floors. The tests were carried out at the Strength laboratory (Structural Engineering Test Hall) at the University of Salerno, Italy and were designed to verify the mechanical properties of metal foam panels and double‐skin glued sandwich panels. The tests have shed light on the basic mechanical properties of both foams and sandwich panels.
Collider signatures of vector-like fermions from a flavor symmetric model
Authors: Bonilla Cesar , Hernández A. E. Cárcamo , Gonçalves João , Freitas Felipe F. , Morais António P. , Pasechnik R. 
Published: January 2022

Abstract
We propose a model with two Higgs doublets and several SU(2) scalar singlets with a global non-Abelian flavor symmetry $$ {\mathcal{Q}}_6\times {\mathcal{Z}}_2 $$

Q
6

×

Z
2

. This discrete group accounts for the observed pattern of fermion masses and mixing angles after spontaneous symmetry breaking. In this scenario only the third generation of fermions get their masses as in the Standard Model (SM). The masses of the remaining fermions are generated through a seesaw-like mechanism. To that end, the matter content of the model is enlarged by introducing electrically charged vector-like fermions (VLFs), right handed Majorana neutrinos and several SM scalar singlets. Here we study the processes involving VLFs that are within the reach of the Large Hadron Collider (LHC). We perform collider studies for vector-like leptons (VLLs) and vector-like quarks (VLQs), focusing on double production channels for both cases, while for VLLs single production topologies are also included. Utilizing genetic algorithms for neural network optimization, we determine the statistical significance for a hypothetical discovery at future LHC runs. In particular, we show that we can not safely exclude VLLs for masses greater than 200 GeV. For VLQ’s in our model, we show that we can probe their masses up to 3.8 TeV, if we take only into account the high-luminosity phase of the LHC. Considering Run-III luminosities, we can also exclude VLQs for masses up to 3.4 TeV. We also show how the model with predicted VLL masses accommodates the muon anomalous magnetic moment.
Real-space RG, error correction and Petz map
Authors: Furuya Keiichiro , Lashkari Nima , Ouseph Shoy 
Published: January 2022

Abstract
There are two parts to this work: first, we study the error correction properties of the real-space renormalization group (RG). The long-distance operators are the (approximately) correctable operators encoded in the physical algebra of short-distance operators. This is closely related to modeling the holographic map as a quantum error correction code. As opposed to holography, the real-space RG of a many-body quantum system does not have the complementary recovery property. We discuss the role of large N and a large gap in the spectrum of operators in the emergence of complementary recovery.Second, we study the operator algebra exact quantum error correction for any von Neumann algebra. We show that similar to the finite dimensional case, for any error map in between von Neumann algebras the Petz dual of the error map is a recovery map if the inclusion of the correctable subalgebra of operators has finite index.
In-process feedback control of tube hydro-forming process
Authors: Endelt Benny 
Published: January 2022

AbstractThe present work will address the problem of designing an in-process control system for a tube hydro-forming process, controlling the tool filling forming a T-tube. The control problem is nontrivial as wrinkling and bursting will develop rapidly and, in most cases, are irreversible—thus, the control system must react fast and without extensive overshoot. The objective is to control the tool filling, reproducing a reference filling trajectory, where the controller input is defined as a correction of the reference forming pressure. The control system was verified experimentally, using four different error scenarios. Initially, the error was provoked, by manipulating the input signal, and for all three cases, the control system successfully eliminates both wrinkling and bursting. Finally, the material was changed going from an aluminum grade 5049-0 to 6060-T6 also; in this case, the control system eliminates the error and stabilizes the process. The control strategy and implementation was developed using numerical simulation (explicit finite element), and the controller implementation was reused directly in the experimental setup without manipulating or scaling the gain factors.
Design and validation of a sheet metal clamping system for additive manufacturing and post-processing
Authors: Ferchow Julian , Bühler Marvin , Schlüssel Marcel , Zumofen Livia , Klahn Christoph , Hofmann Urs , Kirchheim Andreas , Meboldt Mirko 
Published: January 2022

AbstractAutomated clamping for post-processing of mass-customized parts is a challenging step in the laser powder bed fusion (LPBF) process chain. In this study, a novel modular sheet metal clamping system was developed that uses disposable sheet metal profiles as a universal interface for the LPBF, robotic handling, and milling processes. Based on a fundamental investigation of hybrid additive manufacturing, the sheet metal clamping system was designed to use the same interface for the LPBF and milling processes. Subsequent an end-to-end validation was performed for the entire process chain. The concept of the sheet metal clamping system gives milling tools access to a part on five to six sides. Further, the part can be accessed from the top and bottom sides, and simplifying the removal of LPBF supports. No clamping forces are induced in the LPBF part, which is especially important for filigree structures. The sheet metal clamping system’s underlying concept could be adapted to automating the LPBF process chain for applications such as prosthetic dentistry.
Updated Austrian treatment algorithm in HER2+ metastatic breast cancer
Authors: Bartsch Rupert , Gampenrieder Simon Peter , Rinnerthaler Gabriel , Petru Edgar , Egle Daniel , Petzer Andreas , Balic Marija , Pluschnig Ursula , Sliwa Thamer , Singer Christian 
Published: January 2022

SummaryA group of Austrian breast cancer specialists met in December 2020 to establish a comprehensive clinical benefit-risk profile of available HER2-targeted therapies based on recent data and to develop an updated treatment algorithm by consensus over several months in 2021. A total of four scenarios were developed in which treatment strategies appropriate for specific patient profiles were evaluated. Consensus was established by detailed discussions of each scenario and by reaching full consensus.