bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric intracranial pressure surveillance and quantitative outcomes in kids: (PIPSQK) Study
Authors: Wan Ryan , Morgan Madison E , Perea Lindsey L 
Published: March 2022

Objectives Intracranial pressure (ICP) monitoring in pediatric traumatic brain injury (TBI) patients remains controversial. This study aimed to characterize the association between ICP monitoring and mortality for pediatric severe TBI, hypothesizing that ICP monitoring would not be associated with improved survival. Methods Pediatric patients (≤14 years) presenting to Pennsylvania trauma centers from 2003 to 2018 who met severe brain injury criteria (Glasgow Coma Score <9 and Head Abbreviated Injury Scale 4–5) and presented with a blunt mechanism of injury were included. Patients presenting dead on arrival and transfer patients were excluded. Patients were categorized according to ICP monitor placement (ICP+ and ICP−). To assess the effects of ICP monitors on mortality, a multivariate logistic regression model adjusting for demographics and injury patterns was performed. Results A total of 802 pediatric patients met the inclusion criteria. Of those, 28.7% were in ICP+ group ( n = 230) and overall mortality was 33.9% ( n = 272). Despite a higher Injury Severity Score in ICP+ compared to ICP− (33 v. 27, p < 0.001), the mortality rate was lower (22% v. 39%, p < 0.001). The ICP+ group had lower functional statuses at discharge (8 v. 18, p < 0.001). The multivariate logistic regression revealed that presence of an ICP monitor significantly decreased odds of mortality (adjusted odds ratio:0.57, p = 0.027). Conclusion While ICP monitor placement remains controversial in pediatric trauma, there appears to be an association between ICP monitor placement and decreased mortality, despite the ICP monitor group having lower functional status at discharge.
A new GW-based heteroscedastic Gaussian process method for online crack evaluation
Authors: Wang Hui , Yuan Shenfang , Xu Qiuhui , Meng Yixing , Ren Yuanqiang 
Published: March 2022

Accurate evaluation of fatigue crack by using structural health monitoring (SHM) methods is very important to the life management of aircraft structures. However, fatigue crack propagation is always a complicated process for individual aircraft structures during their long-term service. And the monitoring has to be performed under different environmental and operational conditions. These factors result in the uncertain distribution of the damage index obtained by SHM. The distribution usually changes along with the service time, which can be defined as heteroscedasticity. The heteroscedasticity characteristic of the uncertain distribution of damage index has an important negative impact on the SHM based diagnostics algorithms if not considered during the evaluation. However, till now, few researchers have considered this important aspect. To improve the evaluation accuracy under different environmental and operational conditions for individual aircraft, this paper proposes a new guided wave-based heteroscedastic Gaussian process method. Gaussian process quantile regression is adopted to estimate the conditional quantiles of the damage index distribution during the service to deal with the heteroscedasticity. The method is validated on an attachment lug fatigue test, an important aircraft structural component. The experimental results demonstrate that the proposed method can quantify the heteroscedastic uncertainty associated and obviously improve the quality of crack evaluation. For the serious heteroscedastic specimen, the maximum evaluation is only 0.7 mm reduced from the original 7.4 mm, which is an order of magnitude.
Effect of shear stiffening gel rheology on its Kevlar fabric reinforced composite under low-velocity impact
Authors: Zhao Feng , Chen Heng , Gu Han , Jiang Qian , Lu Zhenqian , Wu Liwei 
Published: March 2022

Shear stiffening gel (SSG) with significant shear stiffening effect overcomes the problems of fluid volatilization and particle deposition, and exhibits a wide range of application prospects in intelligent protection. In this work, SSG with different rheological properties were manufactured by mechanical blending and crosslinking and coated on Kevlar fabric. The dynamic rheological properties of SSG and the low-velocity impact resistance of Kevlar/SSG composites were investigated, and the coupling mechanism between SSG and Kevlar fabric was analyzed. The results reveal that the storage modulus of SSG increases by 3–6 orders of magnitude when shear frequency ranges from 0.1 to 100 Hz, and the highest storage modulus reached 2.53 MPa. The impact deformation of the composite is reduced after SSG stiffening, and the infiltration of SSG inside the fabric also prevents fibers pull-out during the impact process. By synergizing the performance of SSG and Kevlar fabric, the optimal single-layer T280 composite can absorb up to 70.21% of the impact energy, reaching the energy absorption efficiency of 0.5 J/g. The process optimization and rheological design provide a theoretical foundation to further enhance the impact resistance performance.
Nutrition and the elite and highly trained junior and young adult tennis player: A scoping review
Authors: Fleming James Andrew , Naughton Robert Joseph , Harper Liam David 
Published: March 2022

Objectives The primary objective of this scoping review was to examine existing evidence regarding the dietary intake and nutrition habits of elite and highly trained junior and young adult tennis players. Methods Systematic searches of MEDLINE, EBSCOHost and Scopus were undertaken from the earliest record to December 2021. Reference lists of articles selected were manually searched. A five-stage protocol informed by Arkey and O’Malley's framework with consideration for the Joanna Briggs Institute (JBI) methodology from scoping reviews was followed. Results The initial searches yielded an initial 145 records following the removal of duplicates. Following the screening process 14 articles were accepted for analyses. Three major themes were identified: (1) dietary intake and negative energy balance, (2) sub-optimal nutrient intake/habits, and (3) the use and impact of dietary supplements/ergogenic aids. Conclusion Research indicates sub-optimal nutritional practices amongst elite and highly trained junior and young adult tennis players. Particular concerns have emerged regarding insufficient calorie consumption to support performance, growth, and wellbeing.
Trapeziectomy with or without a tendon-based adjunct: a registry-based study of 650 thumbs
Authors: Wilcke Maria K. , Evans Kajsa , Franko Mikael Andersson , Arner Marianne 
Published: March 2022

This study aimed to assess the outcomes after simple trapeziectomy and trapeziectomy with ligament reconstruction and/or tendon interposition based on data in the Swedish national healthcare quality registry for hand surgery (HAKIR). Six-hundred and fifty thumbs were included, and 265 were assessed up to 12 months after operation. There was significant and clinically relevant improvement in patient-reported measures (pain on load, pain on motion without load, pain at rest, stiffness, weakness, and ability to perform activities of daily living and the Quick Disabilities of the Arm, Shoulder and Hand score) and objective measures (strength and thumb mobility) at 3 and 12 months for all procedures. The use of the abductor pollicis longus tendon had better improvement in some respects compared with the use of flexor carpi radialis or extensor carpi radialis tendons. However, overall, the use of a tendon adjuncts yielded no better outcomes than simple trapeziectomy. Level of evidence: III
Stiffness- and Bioactive Factor-Mediated Protection of Self-Assembled Cartilage against Macrophage Challenge in a Novel Co-Culture System
Authors: Donahue Ryan P. , Link Jarrett M. , Meli Vijaykumar S. , Hu Jerry C. , Liu Wendy F. , Athanasiou Kyriacos A. 
Published: March 2022

Objective: Tissue-engineered cartilage implants must withstand the potential inflammatory and joint loading environment for successful long-term repair of defects. The work’s objectives were to develop a novel, direct cartilage-macrophage co-culture system and to characterize interactions between self-assembled neocartilage and differentially stimulated macrophages. Design: In study 1, it was hypothesized that the proinflammatory response of macrophages would intensify with increasing construct stiffness; it was expected that the neocartilage would display a decrease in mechanical properties after co-culture. In study 2, it was hypothesized that bioactive factors would protect neocartilage properties during macrophage co-culture. Also, it was hypothesized that interleukin 10 (IL-10)-stimulated macrophages would improve neocartilage mechanical properties compared to lipopolysaccharide (LPS)-stimulated macrophages. Results: As hypothesized, stiffer neocartilage elicited a heightened proinflammatory macrophage response, increasing tumor necrosis factor alpha (TNF-α) secretion by 5.47 times when LPS-stimulated compared to construct-only controls. Interestingly, this response did not adversely affect construct properties for the stiffest neocartilage but did correspond to a significant decrease in aggregate modulus for soft and medium stiffness constructs. In addition, bioactive factor-treated constructs were protected from macrophage challenge compared to chondrogenic medium-treated constructs, but IL-10 did not improve neocartilage properties, although stiff constructs appeared to bolster the anti-inflammatory nature of IL-10-stimulated macrophages. However, co-culture of bioactive factor-treated constructs with LPS-treated macrophages reduced TNF-α secretion by over 4 times compared to macrophage-only controls. Conclusions: In conclusion, neocartilage stiffness can mediate macrophage behavior, but stiffness and bioactive factors prevent macrophage-induced degradation. Ultimately, this co-culture system could be utilized for additional studies to develop the burgeoning field of cartilage mechano-immunology.
Novel imaging phenotypes of naïve asthma patients with distinctive clinical characteristics and T2 inflammation traits
Authors: Yang Zhenyu , Qin Lu , Qiao Jinhan , Cheng Chongsheng , Liu Yiwen , Zhang Shengding , Fang Xiaoyu , Li Zhen , Renz Harald , Liu Xiansheng , Xia Liming , Hu Qiongjie , Xie Min 
Published: March 2022

Objective: This study aims to describe the imaging features of naïve asthma patients, defined as not receiving corticosteroids or other asthma medications for at least 1 month, and their association with therapeutic response, and to discover novel unbiased imaging phenotypes. Methods: A total of 109 naïve asthma patients and 50 healthy controls were enrolled in this study. Clinical data and imaging indices of high-resolution computed tomography were collected. The correlation between imaging indices and clinical features was analyzed. Cluster analyses were adopted to determine three novel imaging phenotypes. Results: Compared with healthy controls, naïve asthma patients presented higher scores of airway remodeling, bronchiectasis, and mucus plugs. Mean airway wall area (WA)% was inversely correlated with mid-expiratory flow velocity% predicted. The extent score of bronchiectasis was positively correlated with smoking history and significantly increased in the high mucus group. Mucus plugs were related to improving lung function and type 2 (T2) inflammation, as assessed by sputum and blood eosinophils and fraction of exhaled nitric oxide. Cluster 1 patients had a high proportion of emphysema, the best lung function, and the lowest T2 inflammation; cluster 2 patients had severe airway remodeling, relatively good lung function, and moderate T2 inflammation; cluster 3 patients had severe airway remodeling, mucus plugs, and bronchiectasis, and showed the worst lung function and highest T2 inflammation. Conclusion: Naïve asthma patients had the imaging traits of airway remodeling, bronchiectasis, and mucus plugs. The unbiased imaging phenotypes had good consistency with clinical characteristics, therapeutic response, and T2 inflammation expression in naïve asthma patients.
Neutralizing antibody responses against SARS-CoV-2 in vaccinated people with multiple sclerosis
Authors: Gyang Tirisham V. , Evans John P. , Miller Joseph S. , Alcorn Kariss , Peng Juan , Bell Erica H. , Zeng Cong , Gumina Richard , Liu Shan-Lu , Segal Benjamin M. 
Published: March 2022

Background Patients with multiple sclerosis (pwMS) are often treated with disease modifying therapies (DMT) with immunomodulatory effects. This is of particular concern following the development of several vaccines to combat coronavirus disease 19 (COVD-19), a potentially fatal illness caused by SARS-CoV-2. Objectives To determine the efficacy of SARS-CoV-2 vaccination in pwMS and the impact of disease modifying therapies (DMT) on vaccine response. Methods This is a prospective longitudinal study in pwMS. Longitudinal serum samples were obtained prior to, and after SARS-CoV-2 mRNA vaccination. A novel neutralizing antibody (nAb) assay was used to determine nAbs titres against SARS-CoV-2 spike. Results We observed that (1) pwMS on B-cell depleting therapies exhibited reduced response to vaccination compared to other pwMS, correlating with time from last anti-CD20 infusion, (2) prior COVID-19 illness, DMT category, and pyramidal function were significant predictors of vaccine responsiveness, and (3) circulating absolute lymphocyte count (ALC) and IgG levels correlated with nAb levels. Conclusions We demonstrate that pwMS exhibit reduced nAb response to mRNA vaccination dependent on DMT status and identify predictive biomarkers for vaccine efficacy. We conclude that additional vaccination strategies may be necessary to achieve protective immunity in pwMS.
Utilization of Preconception Care and Its Associated Factors among Pregnant Women of West Guji Zone, Oromia, Ethiopia, 2021: A Community-Based Cross-Sectional Study
Authors: Amaje Elias , Fikrie Anteneh , Utura Takala 
Published: March 2022

Background Regardless of its benefit in promoting maternal health, contributing to a healthy pregnancy, little is known concerning the prevalence of utilization of preconception care and its determinant in southern Ethiopia. Hence, this study designed to determine the prevalence of utilization of preconception care and contributing factors among pregnant women in West Guji Zone, Southern Ethiopia, 2021. Methods A community-based cross-sectional study was conducted among systematically selected 660 pregnant women in West Guji from June 15 to July 30, 2021. A pretested interviewer-administered structured questionnaire was used to collect the data. Data entry was done in Epidata version3.1 and exported to SPSS version 25 for analysis. Descriptive statistics were used to summarize the data. To identify the factors associated with the utilization of preconception care binary and multivariable logistic regression analysis was performed. Adjusted odds ratios (AOR) with 95% CI were estimated to assess the strength of associations and statistical significance was declared at a p-value < 0.05. Results One hundred-forty seven, 22.3% [95% CI (19.2, 25.4)] of mothers utilized preconception care. Being college and above [(AOR = 5.51 95%CI 91.43-21.19)] and secondary [(AOR = 4.46 95%CI (1.38-14.39)] in educational status, rich [(AOR = 4.23 95%CI (1.32-13.55)], having good knowledge about preconception care [AOR = 2.34 95%CI (1.05-5.28)], having a positive attitude towards preconception care [(AOR = 9.99 95%CI (4.25-23.48)] and deciding with her husband regarding maternal health services [(AOR = 4.71 95%CI (1.91-11.56)] were factors positively affecting utilization of preconception care. Conclusions The utilization of preconception care in the study area is low. Being college and above and secondary in educational status, rich, good knowledge, positive attitude towards preconception care, and deciding with her husband regarding maternal health services were independent factors promoting the utilization of preconception care. Information, education, and communication activities should be strengthened to increase awareness of mothers about preconception care.
Fruit and Vegetable Intake Among Older African American and Hispanic Adults With Cardiovascular Risk Factors
Authors: Kibe Lucy W. , Bazargan Mohsen 
Published: March 2022

African Americans and Hispanics are disproportionately burdened by cardiovascular risk factors including hypertension, diabetes mellitus, and obesity. There is evidence that fruits and vegetables have protective benefits for cardiovascular health. Factors associated with fruit and vegetable intake among older minority adults are not well established. A cross-sectional analysis of African American and Hispanic adults >55 years with diagnosis of hypertension and/or diabetes was conducted. Daily intake of fruits and vegetables was analyzed by socio-demographic, health status, health behaviors, and access to fruits and vegetables. 77% of participants did not meet the United States Department of Agriculture ≥5 a day serving guidelines. Fruit and vegetable consumption was not associated with having hypertension or diabetes. Body mass index >25 and regular exercise were significantly associated with more vegetable intake, but not fruit. African Americans consumed significantly less fruits and vegetables than Hispanics. Among those with access to fruits and vegetables, 78% did not meet the guidelines. Many older African American and Hispanic adults with cardiovascular disease risk factors do not meet the fruit and vegetable intake guidelines. Inadequate intake is worse among African Americans, sedentary, and non-overweight/obese adults. Studies are needed to understand the barriers associated with fruit and vegetable intake in this population.
Linking derived debitage to the Stonehenge Altar Stone using portable X-ray fluorescence analysis
Authors: Bevins Richard E. , Pearce Nick J.G. , Ixer Rob A. , Hillier Stephen , Pirrie Duncan , Turner Peter 
Published: March 2022

AbstractThe Altar Stone at Stonehenge in Wiltshire, UK, is enigmatic in that it differs markedly from the other bluestones. It is a grey–green, micaceous sandstone and has been considered to be derived from the Old Red Sandstone sequences of South Wales. Previous studies, however, have been based on presumed derived fragments (debitage) that have been identified visually as coming from the Altar Stone. Portable X-ray fluorescence (pXRF) analyses were conducted on these fragments (ex situ) as well as on the Altar Stone (in situ). Light elements (Z<37) in the Altar Stone analyses, performed after a night of heavy rain, were affected by surface and pore water that attenuate low energy X-rays, however the dry analyses of debitage fragments produced data for a full suite of elements. High Z elements, including Zr, Nb, Sr, Pb, Th and U, all occupy the same compositional space in the Altar Stone and debitage fragments, and are statistically indistinguishable, indicating the fragments are derived from the Altar Stone. Barium compares very closely between the debitage and Altar Stone, with differences being related to variable baryte distribution in the Altar Stone, limited accessibility of its surface for analysis, and probably to surface weathering.A notable feature of the Altar Stone sandstone is the presence of baryte (up to 0.8 modal%), manifest as relatively high Ba in both the debitage and the Altar Stone. These high Ba contents are in marked contrast with those in a small set of Old Red Sandstone field samples, analysed alongside the Altar Stone and debitage fragments, raising the possibility that the Altar Stone may not have been sourced from the Old Red Sandstone sequences of Wales. This high Ba ‘fingerprint’, related to the presence of baryte, may provide a rapid test using pXRF in the search for the source of the Stonehenge Altar Stone.
Research Progress of Cell Membrane Biomimetic Nanoparticles for Tumor Therapy
Authors: Zhao Xuefen , Yan Chao 
Published: March 2022

AbstractNanoparticles have unique properties and high design flexibility, which are thought to be safe, site-specific, and efficient drug delivery systems. However, nanoparticles as exogenous materials can provide recognition and be eliminated by the body’s immune system, which considerably restricts their applications. To overcome these drawbacks, natural cell membrane coating method has attracted great attention in the field of drug delivery systems, which can prolong nanoparticles blood circulation time and avoiding the capture as well as elimination by the body immune system. Biomimetic nanoparticles via a top-down approach can avoid the laborious group modified engineering and keep the integrity of cell membrane structure and membrane antigens, which can be endowed with unique properties, such as immune escape, longer blood circulation time, targeting delivery and controlling drugs sustain-release. At the present research, erythrocyte membrane, cancer cell membrane, platelet membrane, lymphocyte membrane and hybrid membrane have been successfully coated into the surface of nanoparticles to achieve biological camouflage. Thus, integrating various kinds of cell membranes and nanoparticles into one system, the biomimetic nanoparticles can inherit unique biofunction and drug delivery properties to exhibit tumor targeting-delivery and antitumor outcomes. In this article, we will discuss the prospects and challenges of some basic cell membrane cloaking nanoparticles as a drug delivery system for cancer therapy.
Variation in intraspecific demography drives localised concordance but species-wide discordance in response to past climatic change
Authors: Buckley Sean James , Brauer Chris J. , Unmack Peter J. , Hammer Michael P. , Beheregaray Luciano B. 
Published: March 2022

Abstract
Background
Understanding how species biology may facilitate resilience to climate change remains a critical factor in detecting and protecting species at risk of extinction. Many studies have focused on the role of particular ecological traits in driving species responses, but less so on demographic history and levels of standing genetic variation. Additionally, spatial variation in the interaction of demographic and adaptive factors may further complicate prediction of species responses to environmental change. We used environmental and genomic datasets to reconstruct the phylogeographic histories of two ecologically similar and largely co-distributed freshwater fishes, the southern (Nannoperca australis) and Yarra (N. obscura) pygmy perches, to assess the degree of concordance in their responses to Plio-Pleistocene climatic changes. We described contemporary genetic diversity, phylogenetic histories, demographic histories, and historical species distributions across both species, and statistically evaluated the degree of concordance in co-occurring populations.

Results
Marked differences in contemporary genetic diversity, historical distribution changes and historical migration were observed across the species, with a distinct lack of genetic diversity and historical range expansion suggested for N. obscura. Although several co-occurring populations within a shared climatic refugium demonstrated concordant demographic histories, idiosyncratic population size changes were found at the range edges of the more spatially restricted species. Discordant responses between species were associated with low standing genetic variation in peripheral populations. This might have hindered adaptive potential, as documented in recent demographic declines and population extinctions for the two species.

Conclusion
Our results highlight both the role of spatial scale in the degree of concordance in species responses to climate change, and the importance of standing genetic variation in facilitating range shifts. Even when ecological traits are similar between species, long-term genetic diversity and historical population demography may lead to discordant responses to ongoing and future climate change.