bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loading-Induced Bone Formation is Mediated by Wnt1 Induction in Osteoblast-Lineage Cells
Authors: Lawson Lisa Y. , Migotsky Nicole , Chermside-Scabbo Christopher J. , Shuster John T. , Joeng Kyu Sang , Civitelli Roberto , Lee Brendan , Silva Matthew J. 
Published: February 2022

AbstractMechanical loading on the skeleton stimulates bone formation. Although the exact mechanism underlying this process remains unknown, a growing body of evidence indicates that the Wnt signaling pathway is necessary for the skeletal response to loading. Recently, we showed that Wnts produced by osteoblast lineage cells mediate the osteo-anabolic response to tibial loading in adult mice. Here, we report that Wnt1 specifically plays a crucial role in mediating the mechano-adaptive response to loading. Independent of loading, short-term loss of Wnt1 in the Osx-lineage resulted in decreased cortical bone area in the tibias of 5-month old mice. In females, strain-matched loading enhanced periosteal bone formation in Wnt1F/F controls, but not in Wnt1F/F; OsxCreERT2 knockouts. In males, strain-matched loading increased periosteal bone formation in both control and knockout mice; however, the periosteal relative bone formation rate was 65% lower in Wnt1 knockouts versus controls. Together, these findings show that Wnt1 supports adult bone homeostasis and mediates the bone anabolic response to mechanical loading.
A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0
Authors: Zivanov Jasenko , Otón Joaquín , Ke Zunlong , von Kügelgen Andriko , Pyle Euan , Qu Kun , Morado Dustin , Castaño-Díez Daniel , Zanetti Giulia , Bharat Tanmay A. M. , Briggs John A. G. , Scheres Sjors H. W. 
Published: February 2022

AbstractWe present a new approach for macromolecular structure determination from multiple particles in electron cryo-tomography (cryo-ET) data sets. Whereas existing subtomogram averaging approaches are based on 3D data models, we propose to optimise a regularised likelihood target that approximates a function of the 2D experimental images. In addition, analogous to Bayesian polishing and contrast transfer function (CTF) refinement in single-particle analysis, we describe approaches that exploit the increased signal-to-noise ratio in the averaged structure to optimise tilt series alignments, beam-induced motions of the particles throughout the tilt series acquisition, defoci of the individual particles, as well as higher-order optical aberrations of the microscope. Implementation of our approaches in the open-source software package RELION aims to facilitate their general use, in particular for those researchers who are already familiar with its single-particle analysis tools. We illustrate for three applications that our approaches allow structure determination from cryo-ET data to resolutions sufficient for de novo atomic modelling.
The omnidirectional runway with infinite heading as a futuristic runway concept for future free route airspace operations
Authors: Aydoğan Emre , Demirel Soner 
Published: February 2022

Purpose
The purpose of this paper is to create and analyze the effectiveness of a new runway system, which is totally created for the future free route operations.

Design/methodology/approach
This paper researches and analyses the new generated runway concept with the fast time simulation method. Fuel consumption and environmental effect of the new runway system are calculated based on simulation results.

Findings
According to different traffic density analyses the Omnidirectional Runway with Infinite Heading (ORIH) reduced fuel consumption and CO2 emissions up to 46.97%. Also the total emissions of the ORIH concept, for the hydro carbon (HC), carbon monoxide (CO) and nitrogen oxides (NOx) pollutants were lower than the total emissions with the conventional runway up to 83.13, 74.36 and 51.49%, respectively.

Practical implications
Free route airspaces bring many advantages to air traffic management and airline operations. Direct routes become available from airport to airport thanks to free route airspace concept. However, conventional single runway structure does not allow aircraft operations for every direction. The landing and take-off operations of a conventional airport with a single runway must be executed with only two heading direction. This limitation brings a bottleneck direct approach and departure route usage as convenient with free route airspace concept. This paper suggests and analyzes the omnidirectional runway with infinite heading (ORIH) as a solution for free route airspace.

Originality/value
This paper suggests a new and futuristic runway design and operation for the free route operations. This paper has its originality from the suggested and newly created runway system.
Using new forms of information and communication technologies to empower SMEs
Authors: Jia Shizhen , Tseng Hsiao-Ting , Shanmugam Mohana , Rees Daniel J. , Thomas Roderick , Hajli Nick 
Published: February 2022

PurposeGiven the growing importance and demand for online food purchases, this study explores the new advancements in information and communication technologies (ICTs) by examining the key features of social commerce, trust and product’s attributes in the e-commerce environment. The aim is to investigate possible ICTs-related entrepreneurial opportunities in the food and beverage (F&B) industry.Design/methodology/approachThe study uses a survey to collect data and applies Smart partial least squares to test the model.FindingsThe structural equation modelling results illustrated that social commerce constructs significantly impact trust, leading to customer’s purchase intention. Additionally, product’s attributes was found to have a significant relationship with customer’s purchase intention with trust being the most pertinent driver.Originality/valueThis study contributes to the F&B literature by highlighting the role of new forms of technologies in entrepreneurship activities, especially for small and medium-sized enterprises.
A BIM-based model checking in the green building maintenance: a review
Authors: Ismail Zul-Atfi Bin 
Published: February 2022

Purpose
This paper aims to identify the different system approach using building information modelling (BIM) technology that is equipped with automated evaluation processes. BIM research has mainly focused on theoretical models of acceptance in the green building (GB) maintenance industry. However, BIM has the potential to the competency’s performance and design knowledge of building control instrument. Realising this potential requires a study of BIM at the maintenance planning level, which is considered to be BIM-based model checking (BMC). BMC and its effect in the maintenance planning have not been sufficiently investigated.

Design/methodology/approach
The aim of this paper is to present a critical review of literature on the theoretical background of BMC practices and the main features of information and communication technology tools and techniques in the GB maintenance projects.

Findings
A theoretical framework of BMC is developed and presented. The proposed model incorporates requirement for maintaining a competency’s performance on maintenance planning schemes of GB projects and the importance of early integration of BMC in the design phase to identify alternative methods to cogenerate, monitor and optimise BMC.

Originality/value
It is found that variables facilitating BMC are integrated at different GB maintenance environments levels and are shaped by the context. Directions for future research are presented.
The rise of collaborative engagement platforms
Authors: Leipämaa-Leskinen Hanna , Närvänen Elina , Makkonen Hannu 
Published: February 2022

Purpose
The purpose of this study is to define and analyse the emergence of collaborative engagement platforms (CEPs) as part of a rising platformisation phenomenon. Contrary to previous literature on engagement platforms (EPs), this study distinguishes between formalised and self-organised EPs and sheds light on collaborative EPs on which heterogeneous actors operate without central control by legislated firm actors.

Design/methodology/approach
Drawing on institutional work theory, this paper explores the institutional rules, norms and practices involved in the emergence of a new platform. This paper implements a longitudinal case study of a local food network called REKO and explores how engagement practices and institutional work patterns catalysed its emergence during 2013–2020.

Findings
The findings of this study show that actors engaged within the REKO platform participated in institutional work patterns of disruption, creation and maintenance, which drove the development of the platform and ensured its viability.

Research limitations/implications
This paper encourages future research to further explore how different types of EPs emerge and function.

Practical implications
The rise of CEPs pushes the dominant managerial orientation to progress from the management “of” a platform to managing “within” a platform. For managers, this means developing novel practices for engaging and committing a versatile set of actors to nurture open-ended, multi-sided collaboration.

Originality/value
This study contributes by conceptualising different types of platforms with a particular focus on CEPs and explicating the engagement practices and institutional work patterns that catalyse their emergence.
Investigating the role of risk perception in place-based responses: case studies of the 2003 Bam and 2017 Ezgeleh-Sarpol Zahab earthquakes
Authors: Asadi Saeedeh , Sharghi Ali , Mottaki Zoheir , Salehsedghpour Bahram 
Published: February 2022

Purpose
The purpose of this study is to clarify changes in people-place interrelationship and hidden layers of survivors psychological challenges in the reconstructed housing environment, the 2003 Bam and 2017 Ezgeleh-Sarpol Zahab earthquakes occurred in Iran, because perception of earthquake risk in residential dwellings and traumatic experiences during and after its occurrence are among stressful events making communities face with various spectrum of emotional and cognitive consequences. Such events shape memory “traumascapes” and cause changes in mental schemas and as a result, altering decisions and behavioral responses in long-term familiar environments. Because, in the disaster-affected communities, psychological recovery will be greatly influenced by residential experiences.

Design/methodology/approach
The current research was performed with a qualitative and multicase study design, and data were collected using deep and semistructured private interviews and discussions in focus groups with participation of 33 people by narrative technique.

Findings
According to findings, people are facing enduring cognitive disruptions regarding home concept and its location as a safe and secure paradigm. Findings showed that there are a considerable amount of behavioral responses and emotional consequences in the form of protective behaviors, severe sensitivity to environmental stimuli, fears, phobias in residential dwellings and disturbances in place attachments.

Originality/value
It is noteworthy that despite all time and place differences, the two studied communities had significant similarities in earthquake traumatic experiences and perceptions and also resulting conscious and subconscious responses.
The likelihood of using crowdfunding-Waqf model in Malaysia
Authors: Hapsari Meri Indri , Mohd Thas Thaker Mohamed Asmy Bin , Mohammed Mustafa Omar , Duasa Jarita 
Published: February 2022

Purpose
This paper investigates the probability that people (prospective donors) would be willing to use the crowdfunding-Waqf model (CWM), depending on certain variables and characteristics. This study aims to develop an alternative financial model to address Malaysia’s Waqf land financing problem.

Design/methodology/approach
A survey study was conducted to assess the probability that people would be willing to use the CWM. This study used descriptive analysis and the logistic regression model as analytical tools. Descriptive analysis was conducted using frequencies, which means the number of respondents for each variable or item, such as demographic variables. The logistic regression model was used to obtain the probability that individuals would be willing to use the CWM, based on certain variables.

Findings
This study found that perceived usefulness, perceived ease of use, gender and Waqf knowledge positively affected the likelihood that people would willingly use the CWM for developing Waqf land. In contrast, other factors such as age group, marital status, income level, internet usage, perceived risk of crowdfunding and Waqf perception did not affect this likelihood. Further investigation indicated that being of middle-income level and possessing crowdfunding knowledge positively affected the likelihood that people were willing to use the CWM. The highest probability of the willingness to use the CWM was identified among middle-income males who knew about Waqf and perceived the CWM as useful and easy to use.

Research limitations/implications
The results of this study and other key findings are expected to be implemented by Waqf institutions in Malaysia to develop policies related to Waqf land in general or to the CWM in particular. The findings are also expected to benefit individuals, organisations and countries, and they could also be adapted and validated in other nations.

Originality/value
This study focused on developing a better chance of finding people with specific characteristics and factors that lead them to intentionally use the CWM. The probability of willingness to use the CWM based on certain variables has not yet been evaluated. Recognising how higher probabilities can be identified using every factor and characteristic will enable future CWM users to be better mapped, which is expected to increase the effectiveness of developing the CWM.
Discriminatory abuse: time to revive a forgotten form of abuse?
Authors: Mason Karl , Biswas Sasidharan Anusree , Cooper Adi , Shorten Katy , Sutton Jeanette 
Published: February 2022

Purpose
Discriminatory abuse has been a distinct category of abuse in safeguarding adults policy since 2000, but it is rarely used in practice, according to recent official statistics. As part of a larger project, the authors undertook a literature review to clarify the concept, explore reasons for low reporting and consider recommendations for practice. The purpose of this paper is to present the findings of this literature review.

Design/methodology/approach
This literature review comprises 35 sources, which were identified using three academic databases, reference harvesting and sector-specific websites. Findings were developed through thematic analysis of the data.

Findings
The literature review demonstrates that definitions of discriminatory abuse stretch from an interpersonal emphasis in policy documents to a more structural approach. There are open questions about the status of discriminatory abuse as a category of abuse due to the complicated interface between discriminatory motivations and the abusive acts through which they are experienced. A range of factors can obscure its identification, particularly the hidden, stigmatised and normalised nature of discriminatory abuse. Some recommendations for practice are identified, but more work is needed to develop the practice vocabulary and required skills.

Originality/value
This study brings together existing research on discriminatory abuse to argue that it is time to revive this understanding of abuse and develop safeguarding practice with adults who have protected characteristics.
Idea paper: Controlling trait adaptation to decrease population densities for conservation and management
Authors: Kasada Minoru , Yamamichi Masato 
Published: February 2022

AbstractEcologists and evolutionary biologists have revealed that adaptive microevolution (i.e., allele frequency changes through time) and behavioral changes occur rapidly enough to affect contemporary ecological dynamics, and we can consider rapid adaptation for better conservation and management of wild populations. However, previous studies tended to focus on adaptation that increases population densities (e.g., evolutionary rescue), and did not pay attention to adaptation that decreases population densities (e.g., evolutionary suicide). Here, we demonstrate that controlling trait adaptation may be potentially important for decreasing population densities. One possibility is introducing “selfish” genotypes to populations. If the genotypes increase their reproductive success at the expense of population growth (e.g., cheaters in subsocial ants or coercive males in damselflies), we can decrease population densities (intraspecific adaptation load). The other possible option is diverting trait values of animals from the value that maximizes population growth (ecological trap). For example, we may be able to change behavior of a deer population by hunting so that they will not approach the best habitat with ample resources (landscape of fear). Then, we can consider the optimal allocation of our effort to directly decrease their population densities and control their trait values. However, we should carefully conduct controlling trait adaptation because it may result in unintended outcomes through modified genetic compositions and behaviors, such as increasing genetic variation of the focal population that enhances adaptation to changing environments by introducing selfish genotypes or a transient increase of population densities by modified behaviors.
Going Deeper than ‘Emotional Impact’: Heritage, Academic Collaboration and Affective Engagements
Authors: Fielding Anna 
Published: February 2022

AbstractOrganisations such as the National Trust have recently looked to academia to assist them in the telling of their properties’ stories and contexts. Academia has similarly turned to heritage organisations and sites for audiences they can engage in their variously funded projects, and to fulfil the requirements of the REF (Research Excellence Framework) when it comes to research dissemination. However, the benefits of academic and heritage collaboration go much deeper than these initial mutual attractions. Collaboration can change the nature of audience engagement through affect theory and affective interpretation. This can cause a re‐envisioning of what emotional engagement with a historic site means and highlight the affective potential of heritage visits. This article shows, through case studies, arguments taken from the disciplines of history and heritage studies, and personal experience, how using affective interpretation can convey more complex research in longer‐lasting and more meaningful ways when academia and heritage work together.
Automated pneumothorax triaging in chest X‐rays in the New Zealand population using deep‐learning algorithms
Authors: Feng Sijing , Liu Qixiu , Patel Aakash , Bazai Sibghat Ullah , Jin Cheng‐Kai , Kim Ji Soo , Sarrafzadeh Mikal , Azzollini Damian , Yeoh Jason , Kim Eve , Gordon Simon , Jang‐Jaccard Julian , Urschler Martin , Barnard Stuart , Fong Amy , Simmers Cameron , Tarr Gregory P , Wilson Ben 
Published: February 2022

AbstractIntroductionThe primary aim was to develop convolutional neural network (CNN)‐based artificial intelligence (AI) models for pneumothorax classification and segmentation for automated chest X‐ray (CXR) triaging. A secondary aim was to perform interpretability analysis on the best‐performing candidate model to determine whether the model's predictions were susceptible to bias or confounding.MethodA CANDID‐PTX dataset, that included 19,237 anonymized and manually labelled CXRs, was used for training and testing candidate models for pneumothorax classification and segmentation. Evaluation metrics for classification performance included Area under the receiver operating characteristic curve (AUC‐ROC), sensitivity and specificity, whilst segmentation performance was measured using mean Dice and true‐positive (TP)‐Dice coefficients. Interpretability analysis was performed using Grad‐CAM heatmaps. Finally, the best‐performing model was implemented for a triage simulation.ResultsThe best‐performing model demonstrated a sensitivity of 0.93, specificity of 0.95 and AUC‐ROC of 0.94 in identifying the presence of pneumothorax. A TP‐Dice coefficient of 0.69 is given for segmentation performance. In triage simulation, mean reporting delay for pneumothorax‐containing CXRs is reduced from 9.8 ± 2 days to 1.0 ± 0.5 days (P‐value < 0.001 at 5% significance level), with sensitivity 0.95 and specificity of 0.95 given for the classification performance. Finally, interpretability analysis demonstrated models employed logic understandable to radiologists, with negligible bias or confounding in predictions.ConclusionAI models can automate pneumothorax detection with clinically acceptable accuracy, and potentially reduce reporting delays for urgent findings when implemented as triaging tools.
Financial controller turnover: An early warning sign of deteriorating financial reporting quality
Authors: Lu Junwei , Liu Yaoyao , Krishnan Sudha , Yu Xiaoou 
Published: February 2022

AbstractThis study examines the relation between financial controller turnover and public firms’ financial reporting quality. Exploiting a special institutional setting in China, where financial controllers along with CEOs and CFOs are required to attest to the accuracy and completeness of firms’ annual reports, we find that: (a) financial controller turnover is negatively associated with financial reporting quality, (b) the negative relation between financial controller turnover and financial reporting quality is more pronounced in non‐state‐owned enterprises, in firms with weaker corporate governance, and in areas with higher regulatory enforcement intensity, and (c) financial controller turnover is not related to real earnings management. Further analyses show that financial controller turnover is associated with the incidence of subsequent financial report restatements and enforcement actions by the China Securities Regulatory Commission (CSRC). Financial controller turnover also precedes top executive turnover and can be viewed as an early warning sign of deteriorating financial reporting quality. Such information content is incremental to that of top executive turnover. Our analyses also show that firms with financial controller turnover have higher initial stock returns but underperform their counterparts in the long run.
Forced displacement in history: Some recent research
Authors: Becker Sascha O. 
Published: February 2022

AbstractForced displacement as a consequence of wars, civil conflicts, or natural disasters does not only have contemporaneous consequences but also long‐run repercussions. This eclectic overview summarises some recent research on forced displacement in economic history. While many of the episodes covered refer to Europe, this survey points to literature across all continents. It highlights new developments, and points to gaps in the literature.