bluuebunny/crossref_metadata_2025_split huggingface dataset:
Control optimization of ROV attitude stabilization system based on ETM
Authors: Jiang Lai , Chen Juan , Jin Yongping , Chen Chaoyang , Zhang Xiaoping 
Published: November 2022

Abstract
This study develops an event-triggered controller for the ROV attitude system. First, the dynamic modeling of ROV attitude control is performed. The three-dimensional dynamic equation for ROV attitude control is obtained by decoupling each degree of freedom, and the model for the ROV attitude stability control system is obtained by taking into account the influence of ROV hydrodynamics, ship movement, and umbilical cable vortex-induced vibration. The ROV attitude stability control controller is designed by using backstepping control and sliding mode control, the event trigger mechanism is added to optimize its control output, and the Volterra adaptive multi-step prediction algorithm is designed to predict the ship sinking time series in advance, and the condition parameters are provided for the event trigger mechanism in the AHC controller to improve the positioning accuracy of the attitude stability axial subsystem (AHC). The simulation findings demonstrate that the control strategy and prediction algorithm developed in this study can accomplish the control task and have a strong anti-interference ability by establishing varying degrees of sea conditions and advanced forecast time for simulation tests. Additionally, the event trigger mechanism optimizes the control law, better utilizes the output control signal's channel, and prevents the control output from acting improperly, all of which can reduce network bandwidth use.
Safety of Roxadustat Combined with Epoetin Alfa in Hemodialysis Patients with Anemia: A Cohort Study
Authors: Lu Yi , Liu Xin-yu , Wang Jian-gang 
Published: November 2022

Abstract
Background: Roxadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that stimulates erythropoiesis1, China was the first country in the world to complete phase III clinical trials and was officially approved for marketing in 20182. Recombinant human erythropoietin(rhEPO) is a traditional exogenous supplement of erythropoietin for the treatment of renal anemia.Due to a lack of research on the combination therapy, the FDA(Food and Drug Administration)does not recommend using roxadustat and recombinant human erythropoietin(rhEPO) together3.
Methods: This cohort study was carried out at Nanyang Central Hospital in Nanyang, Henan, China, between January 2020 and January 2022.We compared roxadustat combined with epoetin alfa(combination group) with roxadustat and epoetin alfa for post-dialysis systolic pressure, adverse events(AEs) and major adverse cardiovascular events(MACEs) in end-stage renal disease(ESRD) patients with anemia who were undergoing hemodialysis.The primary outcomes were the mean change in the postdialysis systolic pressure from baseline(BL) to 28 weeeks,and the secondary outcomes were MACEs and AEs.
Results: A total of 96 participants were included. From baseline to weeks 28,the mean(±SE) change in the postdialysis systolic pressure was -6.6±23.3mmHg in the epoetin alfa group,-5.5±26.9mmHg in the roxadustat group, and 8.8±21.0mmHg in the combination group. During a follow-up of 28 weeks, a worsening hypertension occurred in 3 of 42 patients (7.1%) in the epoetin alfa group, in 1 of 35 patients (2.9%) in the raxadustat group and in 0 of 19 patients(0%) in the combination group. The proportion of patients with MACEs and AEs were similar across the three groups.
Conclusions: We found that roxadustat combined with epoetin alfa had greater risk of elevated systolic pressure compared to oral roxadustat or parenteral epoetin alfa as therapy for anemia in Chinese patients undergoing dialysis in the 28 weeks, and the proportion of patients experiencing AEs and MACEs was generally similar across the three grouos.At this time, clinical studies with larger sample size and longer follow-up time are needed to confirm.
Evaluation and management of symptomatic duodenal diverticula: A single-center retrospective analysis of 647 patients
Authors: Ren Jiaqiang , Ding Jiachun , Su Tong , Wu Shuai , Chen Fan , Li Jie , Wang Zheng , Han Liang , Wu Zheng 
Published: November 2022

Abstract
Aims
To explore the clinical characteristics of symptomatic patients and to generalize how to make appropriate treatment choices for this group of patients.
Materials and methods
From January 2010 to September 2020, a total of 647 patients with duodenal diverticula (DD) were included in this study. 345 of them with relevant symptoms were divided into the symptomatic group and the other 302 patients were in the asymptomatic group.
Results
Among all patients, most DD were located in the periampullary area, <1cm in size, and single in number. The distribution of DD localized in the 2nd portion/periampullary (P = 0.002/P < 0.001) and with a 1cm size cut-off value (P = 0.003) was significantly different between the symptomatic and asymptomatic groups. Multivariate Logistics analysis further suggests that diverticular size (< 1cm, 1-3cm) and combined biliary comorbidities (bile duct stones and gallstones, primary bile duct stones, cholangitis without bile duct stones) may be factors influencing the choice of treatment modality. Of all patients undergoing surgical treatment, a total of 7 cases developed various postoperative complications, and no one died.
Conclusions
Patients with DD ≥ 1 cm or located in the periampullary were more likely to be symptomatic. The specific size of the DD and the combination of specific biliary comorbidities may have an impact on the choice of treatment modality.
Glymphatic Dysfunction in Patients with Traumatic Brain Injury Shown by Diffusion Tensor Image Analysis Along the Perivascular Space
Authors: Bian Yitong , Chen Miaomiao , Shang Suhang , Wang Run , Jin Chao , Li Hua , Li Xianjun , Yang Jian 
Published: November 2022

Abstract
Background: glymphatic system has been identified as a pathway in the brain which plays a cential role in brain waste metabolism and immune regulation. The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) method provides an opportunity for the noninvasive approach of the glymphatic system in patients with traumatic brain injury(TBI). This study aimed to investigate the changes of glymphatic function in TBI and its related factors, and to explore the relationship with long-term cognitive outcomes.
Methods: a total of 35 patients with TBI and 50 healthy controls(HCs) were retrospectively included. The clinical characteristics were recorded, including age, sex, glasgow coma scale (GCS), injury reason and type of injury. All participants underwent DTI using the 3.0 T magnetic resonance imaging (MRI) scanner and the ALPS index was calculated. The mini-mental state examination (MMSE) of patients with TBI were followed up by telephone at 6 months. The difference of ALPS index between patients with TBI and HCs was evaluated by independent sample T test. The factors associated with the ALPS index were analysed using linear regression. In addition, the correlation between the ALPS index and MMSE were evaluated in TBI group by pearson analysis.
Results: there were no signiﬁcant diﬀerences in age and sex ratio between patients with TBI and HCs.The ALPS index was statistically different between patients with TBI and HCs (1.343±0.113 vs. 1.432±0.093, p=0.00). In TBI group, GCS (β = 0.013, p = 0.030) was the only factor associated with the ALPS index on linear regression analysis. In addition, the ALPS index in patients with TBI was signiﬁcantly positive correlated with MMSE (r = 0.449, p = 0.007).
Conclusions: we found that DTI-ALPS index was reduced in patients with TBI, indicating glymphatic system dysfunction. Among patients with TBI, the GCS of trauma can affect the glymphatic system, and glymphatic dysfunction was correlated with cognitive impairment. Thus, these ﬁndings can explain the effects of TBI on increased risk of developing dementia and highlight the importance of TBI treatment.
Preparation, characterization, and photocatalytic properties of micro- spherical MoS2
Authors: An Zhongfen , Liu Tong , Wang Xiangyu , Zhang Juhui , Zhang Lingcui , Xu Yue , Shen Yan , Zhao Jinbo , Shi Feng 
Published: November 2022

Abstract
Herein, MoS2 microspheres with a uniform particle size and good crystallinity were prepared by hydrothermal synthesis at 200°C for 24 h. XRD, TEM, and XPS analysis showed that the 2H-MoS2 microspheres were prepared and contained abundant catalytic active sites. Using rhodamine B and methylene blue as simulated environmental pollutants, the photocatalytic activity of MoS2 was analyzed by degrading these organic dyes. Under visible light irradiation, the degradation rate of rhodamine B reached 95% and that of methylene blue reached 98%. During the photocatalytic reaction, the formation of electron-hole pairs in MoS2 was promoted, and strongly-oxidizing hydroxyl radicals (▪OH) were formed by a series of reactions, which degraded the organic substances.
Modified anterior cervical corpectomy fusion in the treatment of four-level cervical spondylotic myelopathy: a retrospective study with 5-year follow-up
Authors: Feng Hao , Bai Rui-fei , Fu Chao-hua , li Wei , Yi Jun-fei , Yang Jian-jie 
Published: November 2022

Abstract
Objective: To investigate the outcome of modified anterior cervical corpectomy and fusion(mACCF) without corpectomy C4 or C5 vertebral body in the treatment of four-level cervical spondylotic myelopathy (CSM).
Methods: 34 consecutive patients suffered from 4 level cervical spondylotic myelopathy were definitely diagnosed from July 2013 to June 2017. All 34 patients were treated by mACCF and followed up at least 5 years. Of these 34 patients, the cervical cord compression was observed at disc levels C2–C6 with/without spinal stenosis in 15 patients, which were treated with corpectomy of C3 and C5 vertebrae and preservation of C4 vertebrae; the cervical cord compression was observed at disc levels C3–C7 with/without spinal stenosis in 19 patients. and were treated with corpectomy of C4 and C6 vertebrae and preservation of C5 vertebrae. Then the operation time, blood loss, bone graft fusion rate at the last follow-up, the improvement rate of JOA score and the cervical lordosis were collected for comparison.
Results: all 34 patients are followed-up from 61 to 84 months, the mean follow-up time is 66.18±11.79 months; The mean operation time was 148.97±31.51min(range,115-192min), The average blood loss was 742.28±87.89ml(range,580-1080ml). All of 34 cases got bony union without complications such as subsidence of titanium mesh cage, displacement of plate or screw was found at last follow-up. The JOA score was (12.46±2.83) before the operation, got improvement to (15.28±2.17), (15.36±2.25) and (16.17±1.83) after operation 3 months,6months and at the last follow-up respectively. The mean improvement rate was 58.8%(3 months after operation), 61.8%(6 months after operation), and 62.9%(the last follow-up);The average cervical lordosis changed from（9.19±3.11）mm before the operation to（12.79±4.15）mm 3 months after operation and（13.11±3.19）mm at last follow-up; Postoperative complications including temporary hoarseness (2 patients), and C5 nerve root palsy (3patients), and improved after 2-week conservative treatments and had resolved completely at the 6-week follow up.
Conclusions: This study demonstrated modified anterior cervical corpectomy and fusion preservation C4 or C5 vertebral body can achieve satisfactory outcome during short and medium-term follow-up in the treatment of 4-level CSM. In this series, neither signifcant subsidence of titanium mesh cage nor signifcant loss of cervical lordosis correction was seen, postoperative lateral radiograph of the cervical spine at last follow-up showing obtaintion of solid fusion.
Secondary Structure of Amorphous Carbon Formed on the Nitrogen-implanted Wc-co Tools During Wood-based Panels Machining
Authors: WILKOWSKI J. , BARLAK M. , KONARSKI P. , KENTSCH U. 
Published: November 2022

Abstract
This paper presents the phenomenon of inducing a secondary structure of amorphous carbon on the nitrogen-implanted surface of WC-Co cutting tools during particleboard machining. Nitrogen ion implantation was performed for two types of WC-Co tools (indexable knives for milling heads and circular saw blades). The following parameters of the ion implantation process were used: fluencies 5e17 cm− 2, ion energy 50 keV. The three layers particleboard with thickness of 18 mm and density 648 kg/m3 was subjected to tool life tests. Workpieces were machined on the woodworking center CNC Busellato Jet 130. During machining, constant cutting parameters were maintained. TEM and SIMS analyzes showed the formation of amorphous carbon secondary structure on the implanted surfaces of WC-Co tools. The thickness of the obtained secondary structure was more than twice greater after sawing than after milling. Formed secondary structure contributed to extension of tool life during particleboard machining.
Development and validation of a deep learning and radiomics combined model for differentiating complicated from uncomplicated acute appendicitis
Authors: Liang Dan , Fan Yaheng , Zeng Yinghou , Zhou Hui , Zhou Hong , Li Guangming , Liang Yingying , Zhong Zhangnan , Chen Dandan , Chen Amei , Huang Bingsheng , Wei Xinhua 
Published: November 2022

Abstract
Background
Nonoperative management (NOM) of uncomplicated acute appendicitis (AA) has been shown to be feasible; however, the pretreatment prediction of complicated/uncomplicated AA remains challenging. We developed a deep learning and radiomics combined model to differentiate complicated from uncomplicated AA.
Methods
This retrospective multicenter study included 1165 adult AA patients (training cohort, 700 patients; validation cohort, 465 patients) with available abdominal pelvic CT images. The reference standard for complicated/uncomplicated AA was surgery and pathology records. We developed our combined model with CatBoost based on the selected clinical characteristics, CT visual features, deep learning features, and radiomics features. We externally validated our combined model and compared it with the conventional combined model, the deep learning radiomics (DLR) model, and the radiologist’s visual diagnosis using receiver operating characteristic (ROC) curve analysis.
Results
In the training cohort, the area under the ROC curve (AUC) of our combined model in distinguishing complicated from uncomplicated AA was 0.816 (95% CI: 0.785–0.844). In the validation cohort, our combined model showed robust performance across the three centers, with AUCs of 0.836 (95% CI: 0.785–0.879), 0.793 (95% CI: 0.695–0.872), and 0.723 (95% CI: 0.632–0.802). In the total validation cohort, our combined model (AUC = 0.799) performed better than the conventional combined model, DLR model and radiologist’s visual diagnosis (AUC = 0.723, 0.755, and 0.679; all P < 0.05). Decision curve analysis showed that our combined model provided greater net benefit in predicting complicated AA than the other three models.
Conclusions
Our combined model allows the accurate differentiation of complicated and uncomplicated AA.
Examination of turbulent flow induced by particle sedimentation by RIM-PIV
Authors: HARADA EIJI , TAZAKI TAKUMI , GOTOH HITOSHI 
Published: November 2022

Abstract
The turbulent flow induced by particles fed into water was measured using refractive index matched-particle image velocimetry (RIM-PIV). The development process of turbulent flow was examined based on PIV on a two-dimensional (2-D) plane. With respect to the measurement results of physical quantities related to the fluctuation velocity, a mottled distribution indicating a particle-scale spatial variation related to the random behavior of each particle spreads over the submerged particle area in the early stage of particle feeding. After the particle feeding was completed and energy supply ceased, the distribution gradually transitioned to a large mottled spatial distribution, showing the organized behavior of the particle cluster. Furthermore, the importance of the measurement in the depth direction and the evaluation of the interaction force between the particles and fluid were shown by examining the turbulent energy budget. In the final part of the development process of the oval circulating flow by feeding particles and its structure, the existence of a shear layer encircling the low-pressure region near the center of the circulating flow was detected.
EFR3A: a new raft domain organizing protein?
Authors: Trybus Magdalena , Hryniewicz-Jankowska Anita , Wójtowicz Karolina , Trombik Tomasz , Czogalla Aleksander , Sikorski Aleksander F. 
Published: November 2022

Abstract

Membrane rafts play a crucial role in the regulation of many important biological processes. Our data suggest that specific interactions of flotillins with MPP1 are responsible for membrane raft domain organization and regulation in erythroid cells. Interaction of the flotillin-based protein network with specific membrane components underlies the mechanism of raft-domain formation and regulation, including in cells with low expression of MPP1. We sought to identify other flotillin partners via the immobilized recombinant flotillin-2-based affinity approach and MS technique. Thereby EFR3A was identified as a candidate protein which interacts with flotillin-2. This was further confirmed via immunoblotting using anti-EFR3A antibody and via co-immunoprecipitation (Co-IP). Moreover, this newly discovered interaction was demonstrated via overlay assay using recombinant EFR3A and flotillin-2. EFR3A is a stable component of the detergentresistant membrane (DRM) fraction of HeLa cells, and its presence was sensitive to removal of cholesterol. While silencing the EFR3A gene, we observed decreased order of the plasma membrane of living cells or giant plasma membrane vesicles (GPMVs) derived from KnD cells and altered mobility of the raft probe, as indicated via fluorescence lifetime imaging microscopy and spot-variation fluorescence correlation spectroscopy. Moreover, silencing of EFR3A expression was found to disturb epidermal growth factor receptor (EGFR) and phospholipase C gamma (PLCγ) phosphorylation and affect EGF-dependent cytosolic Ca2+ concentration. Altogether, our results suggest hitherto unreported flotillin-2-EFR3A interaction, which appears to be responsible for membrane raft organization and regulation. This implies participation of this interaction in the regulation of multiple cellular processes, including those connected with cell signaling.
Association between clinical use of lansoprazole and the risk of type 2 diabetes mellitus: A pharmacoepidemiological cohort study
Authors: Lin Ming-Hsun , Wu Wen‐Tung , Chen Yong-Chen , Lin Tsung-Kun , Chou Yu‐Ching , Sun Chien-An 
Published: November 2022

Abstract
Background
Proton pump inhibitors (PPIs) are common and widely used for gastrointestinal-related disorders. Lansoprazole is one of PPIs with potential benefits of anti-inflammation, reduced oxidative stress, and anti-diabetes. The aims of this study are to determine whether lansoprazole imparts differential risk of type 2 diabetes as compared with other PPIs.
Methods
A population-based retrospective cohort study was conducted using the National Health Insurance Research Database in Taiwan. Patients who received lansoprazole more than 90 days and without records of use of other PPIs between January 1, 2000 and December 31, 2005 (the exposure period) were considered as the exposed cohort (n = 1,668). In comparison, patients who received other PPIs more than 90 days and without use of lansoprazole in the exposure period were treated as the unexposed cohort (n = 3,336).The primary outcome was the new-onset of type 2 diabetes mellitus (T2DM). The association between lansoprazole use and the risk of T2DM was determined by hazard ratios (HRs) and 95% confidence intervals (CIs) derived from multivariable Cox proportional hazards models.
Results
The lansoprazole cohort showed a significantly reduced risk of T2DM with an adjusted HR of 0.65 (95% CI, 0.56–0.76). Interestingly, the inverse association between use of lansoprazole and risk of T2DM was observed in both men and women and in various age groups.
Conclusion
Our findings suggest that lansoprazole was associated with a reduced risk of T2DM compared with other PPIs. Further studies are needed to determine the clinical implications of the present study.
CHEC-UP: A Digital Intervention to Reduce Disparities in Well-Child and Immunization Completion in Community Health
Authors: Mohanty Nivedita 
Published: November 2022

Objective
Well-child visits and immunizations among children in the U.S. declined at the pandemic’s onset and vulnerable populations have been disproportionately affected. This pilot projects tested an innovative mechanism to use chatbots to engage caregivers in evidence-based preventive care for children.
Design
We used artificial intelligence (AI)-enabled chatbots to personalize messages and facilitate appointment scheduling over a five-month period. Chatbots introduced a novel way to connect vulnerable populations to care and challenged traditional convention of provider-patient engagement.
Setting
The pilot study was conducted at a Community Health Center in Chicago, Illinois that serves roughly 10,500 children, and 82% of patients are racial and/or ethnic minorities.
Participants
We targeted outreach to 200 English and Spanish-speaking families with children 0-17 years of age for proactive outreach using chatbots promoting well-child visit completion and up-to-date immunization status; moreover, a special emphasis was placed on the 0-2 age group as the first two years represent a critical time for primary prevention of vaccine-preventable diseases.
InterventionsThe intervention focused on pre-visit engagement by launching an AI-enabled chatbot to deliver personalized messages and facilitate appointment scheduling via mobile devices. CHEC-UP also provided evidence-based anticipatory guidance prior to an appointment. Coaching in preparation for the visit with trusted information has the potential to educate, improve confidence and promote shared decisions between the parent and provider. Patient experience was measured via surveys deployed via the chatbot.
Main Outcome Measures & Results
Chatbots facilitated a relative increase in well-child visits and immunizations by 27% in the intervention group. Well-child visits and immunizations in the intervention group increased 13% compared to the control group. Survey results and patient interviews indicated a high level of patient satisfaction using the chatbot. In addition to a favorable perception of the chatbots, patients also identified future use cases for chatbots.
Conclusions Engaging patients with chatbots improved vaccination and well-child uptake. Patients were highly satisfied with chatbot engagement. By engaging patients and caregivers, chatbots present the potential to proactively engage patients in care and optimize vaccination uptake and realize one of societies’ greatest public health achievements: decreasing the spread of communicable diseases.