bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the wooden structural elements in the Behavior of Traditional masonry buildings
Authors: Chenaghlou Mohammad Reza , Kheirollahi Mohammad , Shahbazi Yaser , Kabirsaber Mohammad bagher 
Published: September 2022

Abstract
Most residential buildings in Iran are constructed from unreinforced masonry walls (URM) which are often characterized by high seismic vulnerability. The majority of these structures were designed only for the gravity loads; therefore, they don’t have adequate resistance and ductility against horizontally-applied loads such as those induced by earthquakes. When these structures are subjected to lateral loads applied by moderate and strong earthquakes, they collapse completely, causing massive death tolls and extensive losses. Iranian seismic history has shown that the majority of masonry buildings were completely destroyed under severe earthquakes, with a number of buildings with timber laces remaining safe and stable. In the past, timber framed masonry structures were built with no design guidelines and were solely based on the experience of traditional Iranian architects. Also, in the construction of these buildings, a form of wooden bracing system is used as the load carrying system. As a result, the buildings often show suitable seismic performance under severe earthquakes. Therefore, the main goal of this study is assessing the effects of timber ties on the seismic behavior of URMs. For this purpose, the plans of Iranian traditional buildings were reviewed and two groups of masonry models were selected to evaluate their seismic vulnerability. Nonlinear static analyses were performed on the models. The results demonstrated that confining masonry walls with timber increases the stiffness and capacity of the studied models. In addition, the performance level of the studied models can be modified from Collapse Prevention (CP) to Life Safety (LS). Also, the results showed that adding timber laces significantly increases the behavior coefficient of the masonry walls. It can therefore be concluded that timber laces significantly influence the performance of masonry structures.
Integrative analysis of host omics and microbiome data provides hints at common pathways and biomarkers for diabetes risk
Authors: Rashad Manar , El-Hadidi Mohamed , Kishk Ali , Hamed Mohamed 
Published: September 2022

Abstract
Background
Type 2 Diabetes (T2D) is a complex metabolic disease whose associated pathways and biomarkers need to be explained using muti-omics integration approach for getting a holistic view for T2D.
Methods
In this study, publicly available host omics data (RNA-seq, proteome, metabolome, and cytokines) were integrated with microbiome 16S rRNA sequencing data from both gut and the nasal cavity of 291 prediabetic and 39 control samples.
Results
Our study uncovered four main insights; first, 27 common pathways between all previous omics data were enriched for functional categories related to amino acids, carbohydrates, and lipid metabolism that are mainly affected by the disruption of the insulin level leading to risk of T2D incident. Second, the metabolome data shared the greatest number of significant pathways with the microbiome data, followed by RNA-seq data, with 14 and 3 pathways, respectively. Third, Glycerophospholipid metabolism was the only pathway that was common between metabolome, RNA-seq, and microbiome data of gut and nasal cavity. Last, the metabolome was the best omic data that was able to distinguish between prediabetic and control samples, with an area under the curve score of 0.98.
Conclusion
Our study succeeded to achieve the host-microbiome integration through finding common pathways and diagnostic biomarkers for progression of prediabetes to T2D.
Hydrochemistry; Compliance And Comparative Case Study of Public Water Works In Enugu And Ebonyi States, Southeast of Nigeria
Authors: J Okenwa C. , P Ikeyi A. , N Owoh E. , E Chinyere E. , C Nnonah C. , onunze Emmanuel. C. 
Published: September 2022

Abstract
The compliance and comparative case study of public water works in Enugu and Ebonyi State of Nigeria was carried out in this study. The water samples were collected at Ajali water treatment plant Enugu State (Sample A), 9 Works road GRA, Enugu State (Sample B), Ezilo water Scheme Ebonyi State (Sample C) and Ameke in Ezilo Ebonyi State (Sample D). Ten physicochemical parameters and water like- metals such as SO42−, Cl−, NO3, Mg2+, Ca2+, Na+, Pb, Ni, Cr, and Al were determined in rainy season in for one year. The results shows that chloride (Cl−), (A = 97 mg/l, B = 121 mg/l, C = 97 mg/l, D = 119 mg/l); nitrate, (A = 3.11 mg/l, B = 1.29 mg/l, C = 1.10 mg/l, D = 0.70 mg/l); total phosphate, (A = 1.97 mg/l, B = 0.26 mg/l, C = 0.32 mg/l, D = 0.42 mg/l); Biological oxygen demand (BOD), (A = 0.25 mg/l, 6.00 mg/k, C = 1.10 mg/l, D = 7.40 mg/l); Chemical oxygen demand (COD), (A = 50.67 mg/l 10.67 mg/l, C = 30.39 mg/l, D = 26.67 mg/l); Electrical conductivity (EC), (A = 100 µs/cm, B = 30 µs/cm, C = 200 µs/cm, D = 250 µs/cm); and pH, (A = 7.60, B = 6.62, C = 5.50, D = 5.90) mostly conform to the WHO set standard for drinking water. While TS, TDS, and TSS were (A = 205, B = 535, C = 151, D = 183 mg/l), (A =,60 B = 555, C = 121, D = 128 mg/l) and (A = 145, B = 280, C = 30, D = 55 mg/l) respectively. Further more, the results of the heavy metal analysed showed that; Lead (Pb) was not detected in all water samples; Nickel (Ni) was observed to be 0.07 mg/l in the water sample collected from Sample A; Sample B contained 0.03 mg/l; Sample C not detected while in Sample D, it was 0.04 mg/l;. Chromium (Cr) was observed to be 0.01 mg/l in Sample A, it was not detected in both water samples B and C but was 0.02 mg/l in Sample D; which means that all the water samples studied conform to the WHO set standard for chromium in drinking water. Aluminium (Al) was observed to be 0.05 mg/l, 0.01 mg/l, Not detected and 0.03 mg/l in water sample A, Sample B, Sample C and Sample D. There is a variation in the Mg2+ in Ebonyi water. Hpwever, It was observed that the physical parameters of the water samples analysed were within the World Health Organisation (WHO) set standard for drinking water.
Resources building for sentiment analysis on content disseminated by Tunisian media in social networks
Authors: Fsih Emna , Boujelbane Rahma , Belguith Lamia Hadrich 
Published: September 2022

Abstract
Nowadays, social networks play a fundamental role in promoting and diffusing television and radio programs to different categories of audiences. So, political parties, influential groups and political activists have rapidly seized these new communication media to spread their ideas andgive their sentiments concerning critical issues. In this context, Twitter, Facebook and YouTube have become very popular tools for sharing videos and communicating with users who interact with each other to discuss some problems, propose solutions and give viewpoints. This interaction on the social media sites yields to a huge amount of unstructured and noisy texts; hence the need for automated analysis techniques to classify sentiments conveyed in the users’ comments. In this work, we focus on opinions written in a less resourced Arabic language: Tunisian dialect (TD). In this work, we present a process for building a sentiment analyses model for comments written on Tunisian television broadcasts published in social media. These comments are written in a particular way with different spellings due to the fact that the Tunisian Dialect(TD) does not have an orthographic standard. For this we design crucial resources, namely sentiment lexicon and annotated corpus that we have used to investigate machine learning and deep learning models in order to identify the best sentiment analysis model for Tunisian Dialect.
Multi-objective design optimization for mild moxibustion considering heat penetration and patient comfort
Authors: Liu Honghua , Huang Zhiliang , Wei Lei , Li Qian , Peng Han , Ge Junyun , Liu Mailan 
Published: September 2022

Abstract
Mild moxibustion is a type of moxibustion treatment approach. The burning end of the moxa stick is kept at a fixed distance from the moxibustion skin, aiming to make the patient feel warm without burning pain. The key to enhancing the efficacy of mild moxibustion is to balance heat penetration and patient comfort by controlling the temperature field distribution. This paper proposes a multi-objective design optimization approach based on global sensitivity for mild moxibustion considering heat penetration and patient comfort. The purpose is to provide optimal mild moxibustion parameters ensuring heat penetration and patient comfort. Firstly, a parametric model of mild moxibustion temperature field was developed through the numerical simulation software of COMSOL. Secondly, global sensitivity was analyzed on the moxibustion parameters, such as the moxa stick burning temperature, moxa stick size, stick-to-skin distance, and ambient temperature. A functional decomposition algorithm was employed to calculate the global sensitivity indexes to accurately evaluate the sensitivity of moxibustion parameters. Thirdly, a multi-objective design optimization problem for the mild moxibustion was modelled. The non-dominated sorting genetic algorithm-II (NSGA-II) was adopted to solve the model to obtain the Pareto-optimal solutions. The proposed approach can solve the moxibustion parameter optimization problem balancing the heat penetration and patient comfort to achieve the optimal mild moxibustion efficacy. Consequently, the theoretical and clinical development of mild moxibustion is promoted.
Local Implementation Variations in China: A Study on Township Pandemic Control during the 2021 Spring Travels
Authors: Dai Anran , Yan Karl , Han Haoying 
Published: September 2022

Abstract
The annual Spring Travels (chunyun) is the largest unidirectional movement of people in China. In 2021, spring travels braced COVID-19. Despite calls to stop adding an extra layer of control on top of national and provincial policies, some district and township governments inadvertently adopted stricter measures. Against this backdrop, this research article asks three research questions. First, why were there variations in pandemic control measures? Second, what were the important actors and factors that contributed to such differences? Third, what does this tell us about local bureaucracy in China? This article argues that there are different decision-making paths, institutionalized and semi-institutionalized, toward successful policy implementation. This article’s findings suggest that institutionalized decision-making mechanisms tend to adopt stricter measures whereas semi-institutionalized ones adopt an inverse strategy.
Taxonomic and functional diversity of flower-visiting insects in coffee crops in Colombia
Authors: Maldonado-Cepeda Juan Diego , Gómez Jesús Hernando , Benavides-Machado Pablo , Jaramillo Juliana , Gil Zulma Nancy 
Published: September 2022

AbstractDespite the important role that flower-visiting insects play in agricultural production, to date no studies have been conducted in Colombia on their role in coffee crops, although coffee is considered the most economically important agricultural crop countrywide. This study therefore aimed to quantify the abundance and richness of flower-visiting insects in coffee crops. A total of 28 lots were selected at five sites in northern, central, and southern Colombia. Thirty trees were selected per evaluation site and per plot and, over a 3-year period, samples of flower-visiting insects were collected daily, at three times of the day, during two flowering seasons per year, accounting for a total of 1,240 hours of observations. Insects were subsequently taxonomically identified, and the number of individuals and species as well as the diversity of order q were estimated. Functional diversity was also characterized in the case of the bee community. A total of 23,735 individuals belonging to 566 species were recorded; of these, 90 were bees, with native species being the most abundant during 10:30 and 13:00. Bees formed five functional groups, with corbiculate and long-tongued non-corbiculate bees being the most abundant and occupying the largest regions of the functional space. Potential pollinators in coffee crops areApis mellifera,Nannotrigona gaboi,Tetragonisca angustula,Geotrigonacf.tellurica, andPartamonacf.peckolti.Coffee crops host a broad diversity of flower visitors, especially bees, which could prove beneficial for coffee productivity in Colombia and contribute to maintaining plant species accompanying coffee cultivation in the country.
Integrated proteogenomic characterization and immune response evaluation reveal an imbalanced hepatocellular carcinoma microenvironment induced by incomplete radiofrequency ablation
Authors: Duan Yu-Xin , Wu Zhong-Jun , Cui Fang , Shi Zheng-Rong , Yan Xiong , Song Pei-Pei , Peng Qiling , Li Mao-Ping , Xiao Heng , Lan Xiang , Ye Wen-Tao , Yin Kun-Li , Tang Wei , Liao Rui 
Published: September 2022

Abstract
Background: Efforts to precisely assess tumor-specific T-cell immune responses capable of mediating imbalanced hepatocellular carcinoma (HCC) ecosystems after incomplete radiofrequency ablation (iRFA) still face major challenges. Here, we assessed the immune response and performed transcriptomic and proteomic analyses in patients with HCC following iRFA.
Methods: Peripheral blood and tissue samples were collected from HCC patients who underwent RFA. Multiplex immunostaining and flow cytometry were used to assess the local and systemic immune response. Differentially expressed genes (DEGs) and differentially expressed proteins (DEPs) were explored via transcriptomic and proteogenomic analyses. The ability of proteinase-3 (PRTN3) to predict overall survival (OS) was assessed in HCC patients with early recurrence after RFA.
Results: Multiplex immunostaining revealed no immediate significant change in local immune cell counts. Flow cytometry analysis showed that the levels of CD4+ T cells, CD4+CD8+ T cells, and CD4+CD25+CD127- Treg cells were significantly increased, while the levels of CD16+CD56+ natural killer cells were significantly decreased on day 5 after cRFA (P<0.05). Transcriptomics and proteomics allow the identification of hundreds of DEGs and DEPs. Pathways related to immunoinflammation response, cancer progression and metabolism were found to be dysregulated at the transcriptomic and proteomic levels. Proteinase 3 (PRTN3) was observed to be persistently upregulated at the gene and protein levels and closely associated with the OS of early recurrent HCC following RFA.
Conclusion: This study provides a comprehensive overview of the immune response and transcriptomic and proteogenomic landscapes of HCC milieus, revealing the mechanisms involved in the iRFA-induced immune response and tumor progression.
Trial registration: ChiCTR2200055606, http://www.chictr.org.cn/showproj.aspx?proj=32588.
Advanced Research in Cellular Pharmacokinetics and its Cutting-edge Technologies
Authors: Lv Lingjuan , You Yuyang , Liu Yeju , Yang Zhihong 
Published: September 2022

Abstract:
Pharmacokinetics (PK), as a significant part of pharmacology, runs through the overall process of the
preclinical and clinical research on drugs and plays a significant role in determining the material basis of efficacy
and mechanism research. However, due to the limitations of classical PK, cellular PK was put forward and
developed rapidly. Many novel and original technologies have been innovatively applied to cellular PK research,
thereby providing powerful technical support. As a novel field of PK research, cellular PK expands the
research object and enriches the theoretical framework of PK. It provides a new perspective for elucidating the
mechanism of drug action and the dynamic process of drug in the body. Furthermore, it provides a scientific
basis and guiding significance for the development of new drugs and clinical rational drug use. Cellular PK can
explain the dynamic process of certain drugs (e.g., antineoplastic drugs and antibiotics) and the disposition kinetics
characteristics in some specific tissues (e.g., brain and tumor) in a clearer and more accurate manner. It is
a beneficial supplement and the perfection of traditional PK. In the future, traditional and cellular PKs will
complement each other well and improve into an all-around research system in drug developments. Briefly, this
paper reviews the conceptual development of cellular PK and key associated technologies, explores its main
functions and applications, and looks forward to the important pioneering significance and promising value for
the development of PK.
Nanomedicine and Addictive Disorders: A New Approach With Cannabinoids
Authors: Giménez Virna Margarita Martín , Menéndez Sebastián García , Manucha Walter 
Published: September 2022

Background:
Most cannabinoids usually present several limitations when evaluating their clinical
use, mainly related to the side effects they may cause at the central nervous system and other levels. In this
regard, nanotechnology applied to the development of pharmacotherapeutic nanoformulations has become an
attractive tool that allows taking advantage of the beneficial properties of multiple drugs while minimizing or
avoiding their undesirable side effects. Nanotechnology is a relatively recent scientific field that involves the
study, manipulation, development, and characterization of drug delivery systems at the nanoscale (1 to 1000
nm; 1 nm= 1x10-9 m). Usually, the physicochemical properties of matter at the nanoscale are significantly different
compared to the matter at the macroscale, which provides several advantages over conventional therapeutic
alternative types of organic and inorganic drug delivery nanosystems. Posology, size, composition, surface
properties, and different physicochemical characteristics may directly or indirectly influence their pharmacodynamic
and pharmacokinetic behavior and, consequently, their biomedical use.

Purpose of Review:
This mini-review summarizes the main recent findings on nanomedical strategies and
applications for cannabinoid encapsulation, raising the possibility of transferring these advances to the therapy
of addictions.

Highlights Standpoints:
The nano therapy significantly improves the pharmacokinetic and pharmacodynamic
behavior of multiple active pharmaceutical ingredients with different limitations and disadvantages, thus
enhancing the therapeutic compliance of patients. In general, cannabinoids loaded in nanoformulations offer
greater efficacy, lower toxicity and more controlled/prolonged release than cannabinoids in free form.
Tetraspanin-enriched Microdomain Containing CD151, CD9, and TSPAN 8 –
Potential Mediators of Entry and Exit Mechanisms in Respiratory Viruses Including
SARS-CoV-2
Authors: Malla RamaRao , Kamal Mohammad Amjad 
Published: September 2022

Abstract:
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan,
the Hubei region of China, has become a pandemic worldwide. It can transmit through droplets and enter via
oral, nasal, and eye mucous membranes. It consists of single-stranded RNA (positive-sense), nonstructural proteins
including enzymes and transcriptional proteins, and structural proteins such as Spike, Membrane, Envelope,
and Nucleocapsid -proteins. SARS-CoV-2 mediates S-proteins entry and exit via binding to host cell surface
proteins like tetraspanins. The transmembrane tetraspanins, CD151, CD9, and tetraspanin 8 (TSPAN8),
facilitate the entry of novel coronaviruses by scaffolding host cell receptors and proteases. Also, CD151 was
reported to increase airway hyperresponsiveness to calcium and nuclear viral export signaling. They may facilitate
entry and exit by activating the serine proteases required to prime S-proteins in tetraspanin-enriched microdomains
(TEMs). This article updates recent advances in structural proteins, their epitopes and putative receptors,
and their regulation by proteases associated with TEMs. This review furnishes recent updates on the role
of CD151 in the pathophysiology of SARS-CoV-2. We describe the role of CD151 in a possible mechanism of
entry and exit in the airway, a major site for infection of SARS-CoV-2. We also updated current knowledge on
the role of CD9 and TSPAN 8 in the entry and exit mechanism of coronaviruses. Finally, we discussed the importance
of some small molecules which target CD151 as possible targeted therapeutics for COVID-19. In conclusion,
this study could identify new targets and specific therapeutics to control emerging virus infections.
Lung Pneumonitis and Fibrosis in Cancer Therapy: A Review on Cellular and Molecular Mechanisms
Authors: Xu Chaofeng , Najafi Masoud , Shang Zhongtu 
Published: September 2022

Abstract:Fibrosis and pneumonitis are the most important side effects of lung tissue following cancer therapy. Radiotherapy and chemotherapy by some drugs, such as bleomycin, can induce pneumonitis and fibrosis. Targeted therapy and immunotherapy also may induce pneumonitis and fibrosis to a lesser extent compared to chemotherapy and radiotherapy. Activation of lymphocytes by immunotherapy or infiltration of inflammatory cells such as macrophages, lymphocytes, neutro-phils, and mast cells following chemo/radiation therapy can induce pneumonitis. Furthermore, the polarization of macrophages toward M2 cells and the release of anti-inflammatory cytokines stimu-late fibrosis. Lung fibrosis and pneumonitis may also be potentiated by some other changes such as epithelial-mesenchymal transition (EMT), oxidative stress, reduction/oxidation (redox) responses, renin-angiotensin system, and the upregulation of some inflammatory mediators such as a nuclear factor of kappa B (NF-κB), inflammasome, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS). Damages to the lung vascular system and the induction of hypoxia also can induce pulmonary injury following chemo/radiation therapy. This review explains various mechanisms of the induction of pneumonitis and lung fibrosis following cancer therapy. Furthermore, the targets and promising agents to mitigate lung fibrosis and pneumonitis will be discussed.
Downregulation of miR-125a-5p Leads to STAT3 Increased Expression in
Breast Cancer Patients
Authors: Shishavan Negar Shafagh , Sasani Soheila Talesh , Salehi Zivar , Azhang Masoumeh Rezaei 
Published: September 2022

Background:
Breast cancer (BC) is one of the main causes of cancer-related death in
women worldwide. It is necessary to find methods for prognosis and early detection of BC. MicroRNAs
inhibit the expression of special target genes at the post-transcriptional stage and have a
fundamental role in various cancers. They function as oncogenes or tumor suppressors. MiR-125a-
5p acts as a tumor suppressor in some cancers through a signal transducer and activator of transcription
3 (STAT3) suppression. STAT3 is activated in response to cytokines and growth factors, affecting
the transcription of target genes.

Objective:
We examined the association between miR-125a-5p and STAT3 expression levels in
breast cancer patients for the first time through a case-control study on an Iranian population.

Methods:
Total RNAs were extracted from breast cancer and healthy tissues using TRIzol Reagent.
Complementary DNA synthesis was performed, and Real-time PCR was done using miR-125a and
STAT3-specific primers. GAPDH and U48 genes were used as internal controls. Statistical analysis
of the results was conducted by SPSS v.19.0 software.

Results:
We obtained a significant association between miR-125a-5p down-regulation and breast
cancer disease (0.4333 in patients vs. 1.656 in controls, p-value = 0.009). STAT3 expression was
significantly up-regulated in BC samples relative to healthy subjects (1.324 vs. 0.6557, respectively)
and p-value <0.0001.

Conclusion:
We investigated that decreased miR-125a-5p expression levels were significantly associated
with increased STAT3 expression in BC tissues. Therefore, the expression changes of miR-
125a-5p can be an important potential biomarker for early diagnosis of breast cancer. Also, the
miRNA molecule may have serious therapeutic potential.