bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nilai Kearifan Lokal: Projek Paradigma Baru Program Sekolah Penggerak untuk Mewujudkan Profil Pelajar Pancasila
Authors: Nurasiah Iis , Marini Arita , Nafiah Maratun , Rachmawati Nugraheni 
Published: May 2022

Tujuan penelitiannya untuk menganalisa nilai kearifan lokal dalam paradigma baru pendidikan yang merupakan bagian dari kurikulum merdeka belajar mengarahkan peserta didik untuk menghargai dan mencintai budaya bangsa. Kegiatan pembelajran sepanjang hayat untuk mengembangkan potensi peserta didik melalui nilai kearifan local sangat mendukung terwujudnya profil pelajar Pancasila. Pembangunan karakter merupakan sebuah kebutuhan dalam proses berbangsa, karena hanya bangsa yang memiliki karakter dan jati diri yang kuat akan menjadi bangsa yang besar dan bermartabat. Oleh sebab itu implementasi di sekolah dalam bentuk pendidikan karakter merupakan upaya untuk membantu peserta didik mengenal, menyadari dan menghayati aspek-aspek sosial, moral, etika, yang dapat dijadikan acuan dalam bersikap dan berperilaku sebagai salah satu dimensi dari kompetensi lulusan berdasarkan nilai-nilai Pancasila. Metode penelitian ini adalah Libary research ( Penelitian pustaka) yaitu penelitian yang dilaksanakan dengan cara membaca, menelaah dan mencatat berbagai literatur atau bahan bacaan yang sesuai dengan pokok bahasan. Hasil penelitian menemukan bahwa nilai kearifan local merupakan atrategi yang dapat mewujudkan Paradigma baru dalam kompetensi global untuk mewujudkan kompetensi global menuju profil pelopor Pancasila melalui pendidikan karakter dalam sekolah penggerak.
Development of Immersive Virtual Reality Environment for Assessment of Functional Vision in people with Low Vision: A Pilot Study
Authors: Gopalakrishnan Sarika , Jacob Chris Elsa Samson , Kumar Meenakshi , Karunakaran Vijay , Raman Rajiv 
Published: May 2022

Introduction: Virtual Reality technology helps in creating virtual environments for evaluation of visual performance of low vision individuals with holistic experience. The purpose of this study was to develop a virtual reality (VR) platform for the objective assessment of functional vision in patients with low vision in two categories, central and peripheral vision loss .
Materials and methods: Focus group discussions (FGD) were organized to understand the difficulties faced on a day to day basis by patients with low vision. Based on the results of the focus group discussions, a virtual bank scenario incorporating specific visual tasks was developed. A pilot study was conducted which involved people with normal vision; low vision Patients secondary to central field loss (CFL) and peripheral field loss (PFL). Each subject completed all the tasks in the objective assessment; the data obtained from the assessment were further analyzed to understand the pattern.
Results: Comparing the three groups, there was a significant difference in distance (central field loss was lowest) and near visual angle, and three visual search tasks (peripheral field loss was lowest). In assessing the time taken, peripheral field loss group was again found to take the most time to complete tasks.
Conclusion: Based on a newly developed virtual reality platform, assessment of functional vision of specially abled persons could be tested and was inferior to that of normal sighted persons. in a close to realistic environment. Multiple visual tasks were performed in the virtual environment and the visual performance was compared among all three groups of participants. Participants were matched for age and gender. Irrespective of the nature of tasks, visual performance of the normal group seemed significantly better than people with CFL and PFL.
Prevalence, Associated Factors and Awareness of Hypertensive Retinopathy among an Elderly Population with Hypertension in Nepal: The Bhaktapur Retina Study
Authors: Thapa Raba , Khanal Shankar , Tan Hendra Stevie , Thapa Suman Shumsher , Van Rens Gerardus Hermanus Maria Bartholomeus 
Published: May 2022

Introduction: Hypertensive retinopathy is a common complication in patients with hypertension. This study aims to assess the prevalence, associated factors and awareness of hypertensive retinopathy among an elderly population with hypertension in Bhaktapur, Nepal.
Materials and methods: This is a population-based, cross-sectional study conducted from 2013 to 2015 in Bhaktapur district, Nepal. The sample size was 2100 subjects aged 60 years and above. From this sample, all diagnosed patients with hypertension were analyzed. A detailed history was obtained, and an ocular examination was performed.
Results: Information was complete for 1860 (88.57%) subjects. The age of the study population ranged from 60 to 95 years with the mean age of 69.64±7.31 years. Hypertension was found in 643 subjects (34.61%), of which 224 (12.04%) were newly diagnosed cases. Among the subjects with hypertension, hypertensive retinopathy was found in 81 cases (12.6%). Hypertensive retinopathy was more frequent in the age group 70-79 years (15.23%), males (13.25%), illiterates (13.56%), diabetics (16.49%), and body mass index (BMI) ≥25 kg/m2 (14%). None of the factors was found to be statistically significant. Among the study participants, awareness regarding the effect of hypertension on eye, retina and vision was found to be 13.84%, 8.4%, and 11.98% respectively.
Conclusion: Prevalence of hypertension and hypertensive retinopathy among an elderly population of 60 years and above in Bhaktapur district, Nepal were similar to other countries. Hypertensive retinopathy was higher among males, illiterates, diabetes and BMI> 25kg/m2. Awareness of hypertensive retinopathy was 8.4% among hypertensive subjects. Emphasis should be directed toward improving awareness campaigns.
Toward a Postimperial Order?
Authors: Korobeinikov Aleksandr , Antonov Egor 
Published: May 2022

Abstract
Focusing on the works and intellectual activity of the Sakha intelligentsia, this article examines the development of postimperial political imagination in the region of Yakutia. The formation of the Sakha intellectuals was a result of the circulation of wider imperial discourses on nationalism, anticolonialism, socialism, and regionalism during the crisis of the Russian Empire. By discussing the Sakhas’ marginal, even colonial, conditions, the Sakha national intellectuals followed self-governing aspirations inherited from political exiles and Siberian regionalists, whose ideas became frequent demands for many Siberian indigenous movements. Despite the Stalinist myth that the Soviet Union (and its social engineers) created autonomy in Yakutia for the first time in Russian history, it was the Sakha intellectuals who developed the autonomist discourse during the first two decades of the twentieth century.
Intracranial complications of hypercoagulability and superinfection in the setting of COVID-19: illustrative cases
Authors: Blitz Sarah E. , McMahon J. Tanner , Chalif Joshua I. , Jarvis Casey A. , Segar David J. , Northam Weston T. , Chen Jason A. , Bergmark Regan W. , Davis Jennifer M. , Yawetz Sigal , Arnaout Omar 
Published: May 2022

BACKGROUND
Hypercoagulability with thrombosis and associated inflammation has been well-documented in COVID-19, and catastrophic cerebral venous sinus thromboses (CVSTs) have been described. Another COVID-19–related complication is bacterial superinfection, including sinusitis. Here, the authors reported three cases of COVID-19–associated sinusitis, meningitis, and CVST and summarized the literature about septic intracranial thrombotic events as a cause of headache and fever in COVID-19.

OBSERVATIONS
The authors described three adolescent patients with no pertinent past medical history and no prior COVID-19 vaccinations who presented with subacute headaches, photosensitivity, nausea, and vomiting after testing positive for COVID-19. Imaging showed subdural collections, CVST, cerebral edema, and severe sinus disease. Two patients had decline in mental status and progression of neurological symptoms. In all three, emergency cranial and sinonasal washouts uncovered pus that grew polymicrobial cultures. After receiving broad-spectrum antimicrobials and various additional treatments, including two of three patients receiving anticoagulation, all patients eventually became neurologically intact with varying ongoing sequelae.

LESSONS
These cases demonstrated similar original presentations among previously healthy adolescents with COVID-19 infections, concurrent sinusitis precipitating CVST, and subdural empyemas. Better recognition and understanding of the multisystem results of severe acute respiratory syndrome coronavirus 2 and the complicated sequelae allows for proper treatment.
Single-stage cranioplasty with customized polyetheretherketone implant after tumor resection using virtual reality and augmented reality for precise implant customization and placement: illustrative case
Authors: Rios-Vicil Christian I. , Barbery Daniela , Dang Phuong , Jean Walter C. 
Published: May 2022

BACKGROUND
Cranioplasties are routinely performed to restore cosmesis and to protect intracranial contents after trauma, resection of tumors, or other pathologies. Traditionally done as a second-stage procedure, new single-stage cranioplasty protocols have been developed to minimize recovery periods, decrease complications, and improve patient satisfaction. These protocols, however, still require the use of larger than planned implants or use larger than ideal incisions to accommodate three-dimensional (3D) templates, which may not be optimal in regions with complex bony anatomy.

OBSERVATIONS
A 50-year-old woman with a painful and progressively enlarging hemangioma of the left frontal bone underwent a single-stage resection followed by custom cranioplasty using a new extended reality (XR)-based workflow. Excellent cosmetic results, decreased operative time, and a feasible workflow were achieved.

LESSONS
The use of an XR-based visualization platform allows the surgeon to treat lesions and perform custom cranioplasties in one session while avoiding common pitfalls of current single-stage workflows, such as increased operative times for tailoring implants, as well as minimizing the use of 3D overlay models, which may not appropriately conform to complex regional bony anatomy intraoperatively.
JALUR KHUSUS (PLEA BARGAINING) DALAM HUKUM ACARA PIDANA
Authors: Fratama Rezky Abdi 
Published: May 2022

Apart from analyzing, this research aims to know whether the concept of Jalur Khusus (Plea Bargaining) in settlement of criminal cases matches the legality Principle. Moreover, the research aimed to analyze how the legal arrangement of Jalur Khusus (Plea Bargaining) is in criminal procedural law in future. The used research method is normative legal research that focuses on exploring whether the concept of Jalur Khusus (Plea Bargaining) in settlement of criminal cases matches the legality. The second focus is to explore how the legal arrangement of Jalur Khusus (Plea Bargaining) is in criminal procedural law for the future. This research uses the approach of legislation (Statute Approach), primarily Law No. 8 of 1981 on the Criminal Procedure code, along with all its implementing regulations and other relevant legislation, conceptual approach (Conceptual Approach), especially about the special pathways (Plea Bargaining), and comparative approach (Comparative Approach) specifically the arrangement of plea bargaining in other countries such as the United States, Canada, United Kingdom, France, Georgia, Poland and Italy. The research results, namely the Jalur Khusus (Plea Bargaining) concept in settlement of criminal cases, are not appropriate or contrary to the Legality Principle. The reason is the system of proof, and formal truth will be hindered. According to an article in 3 KUHAP, it is already explicitly mentioned that the judiciary is carried out in the way stipulated in the law a quo. The legal arrangement of the concept of "Jalur Khusus" in the Criminal Procedural Law for the future in accordance with the context of the criminal justice system in Indonesia. Also, following the Principle of simple justice quickly and lightly costs are clarifying the negotiating parties in a special line, things negotiated in a special line, adding regulation of stages in a special path, criminal acts that can use special channels, and the form of agreement and binding power in jalur khusus.
Perlindungan Hukum Konsumen dalam Jual Beli Online dengan Jasa Escrow
Authors: Perdana Arya Putra , Muttaqin Azhar , Arief Sofyan 
Published: May 2022

Tujuan peneitian ini adalah untuk mengetahui bagaimana perlindungan terhadap konsumen yang menggunakan jasa escrow dalam melakukan transaksi jual beli online dilihat dari hukum positif melalui undang-undang perlindungan konsumen, undang-undang informasi dan transaksi elektronik, peraturan pemerintah tentang penyelenggaraan sistem transaksi elektronik dan undang-undang perdagangan. Sedangkan melalui hukum islam melalui Muamalah, Samsarah, Al-Ba’i, Perikatan Islam dan Khiyar.Penelitian ini menggunakan jenis penelitian hukum normatif, serta menggunakan sumber bahan hukum primer berupa Al-Qur’an, Hadis, Fikih, hasil Ijtihad ulama, Undang-Undang Nomor 08 Tahun 1999 tentang Perlindungan Konsumen, Undang - Undang Nomor 11 Tahun 2008 tentang Informasi dan Transaksi Elektronik, Peraturan Pemerintah Nomer 82 Tahun 2012 tentang Penyelenggaraan Sistem dan Transaksi Elektronik, Undang - Undang Nomor 7 Tahun 2014 tentang Perdagangan. Bahan hukum sekunder seperti pendapat ahli hukum, teori, hasil karya dari kalangan hukum, penelusuran internet, artikel ilmiah, jurnal, dan makalah. Sedangkan bahan hukum tersier berupa kamus, ensiklopedia dan sebagainya.Hasil dari penelitian ini menunjukan bahwa Perlindungan Hukum Terhadap Konsumen dalam Praktik Jual Beli Online dengan Jasa Escrow Menurut Hukum Positif Dan Hukum Islam sudah sangat baik dilakukan oleh toko online penyedia jasa escrow, hal ini berdasarkan isi syarat dan ketentuan dari toko online yang sesuai dengan pasal-pasal yang ada dalam Undang-Undang Nomor 08 Tahun 1999 tentang Perlindungan Konsumen, Undang - Undang Nomor 11 Tahun 2008 tentang Informasi dan Transaksi Elektronik, Peraturan Pemerintah Nomer 82 Tahun 2012 tentang Penyelenggaraan Sistem dan Transaksi Elektronik, Undang - Undang Nomor 7 Tahun 2014 tentang Perdagangan. Namun dari 6 tujuan perlindungan konsumen ada 1 poin yang tidak terpenuhi karena penyedia jasa toko online membuat standart contract untung melepaskan tanggung jawab mengganti kerugian penggunanya. Begitu pula dalam hukum Islam, standart contract tentang pelepasan tanggung jawab tidak sesuai dengan prinsip keadilan dalam muamalah.
Alfabetização científico-tecnológica no currículo de ciências dos anos iniciais:
Authors: Kleszta Sandra Fabiane , Santos Rosemar Ayres dos 
Published: May 2022

A sociedade tem sofrido cada vez mais rápidas transformações, isso repercute na escola. Objetivamos (re)conhecer os desafios e as possibilidades de ensino para a promoção da Alfabetização Científico-tecnológica no Ensino de Ciências para os Anos Iniciais a partir da aproximação dos pressupostos de Freire e o enfoque CTS. É uma pesquisa qualitativa, cujo corpus de análise foi composto por teses e dissertações do repositório do IBICT. A partir da análise emergiram quatro categorias: desafios para a configuração curricular sob a perspectiva de Freire e CTS; Práticas educativas com abordagem CTS presentes no Currículo; Aproximações entre enfoque Freire e CTS: auxiliando os educadores dos Anos Iniciais a melhor compreender o Ensino de Ciências; ECT e a ACT: importância para o Ensino de Ciências nos Anos Iniciais. Sinalizamos a necessidade de mudança na formação dos educadores, através de formação continuada, para que ampliem seus conhecimentos acerca de um currículo mais emancipatório.
Changes in Elastic Moduli of Fibrin Hydrogels Within the Myogenic Range Alter Behavior of Murine C2C12 and Human C25 Myoblasts Differently
Authors: Tomasch Janine , Maleiner Babette , Heher Philipp , Rufin Manuel , Andriotis Orestis G. , Thurner Philipp J. , Redl Heinz , Fuchs Christiane , Teuschl-Woller Andreas H. 
Published: May 2022

Fibrin hydrogels have proven highly suitable scaffold materials for skeletal muscle tissue engineering in the past. Certain parameters of those types of scaffolds, however, greatly affect cellular mechanobiology and therefore the myogenic outcome. The aim of this study was to identify the influence of apparent elastic properties of fibrin scaffolds in 2D and 3D on myoblasts and evaluate if those effects differ between murine and human cells. Therefore, myoblasts were cultured on fibrin-coated multiwell plates (“2D”) or embedded in fibrin hydrogels (“3D”) with different elastic moduli. Firstly, we established an almost linear correlation between hydrogels’ fibrinogen concentrations and apparent elastic moduli in the range of 7.5 mg/ml to 30 mg/ml fibrinogen (corresponds to a range of 7.7–30.9 kPa). The effects of fibrin hydrogel elastic modulus on myoblast proliferation changed depending on culture type (2D vs 3D) with an inhibitory effect at higher fibrinogen concentrations in 3D gels and vice versa in 2D. The opposite effect was evident in differentiating myoblasts as shown by gene expression analysis of myogenesis marker genes and altered myotube morphology. Furthermore, culture in a 3D environment slowed down proliferation compared to 2D, with a significantly more pronounced effect on human myoblasts. Differentiation potential was also substantially impaired upon incorporation into 3D gels in human, but not in murine, myoblasts. With this study, we gained further insight in the influence of apparent elastic modulus and culture type on cellular behavior and myogenic outcome of skeletal muscle tissue engineering approaches. Furthermore, the results highlight the need to adapt parameters of 3D culture setups established for murine cells when applied to human cells.
Lower Circulating Leptin Levels Are Related to Non-Alcoholic Fatty Liver Disease in Children With Obesity
Authors: Brandt Stephanie , von Schnurbein Julia , Denzer Christian , Kratzer Wolfgang , Wabitsch Martin 
Published: May 2022

BackgroundWhile for individuals with obesity an association between hyperleptinemia and an increased risk of non-alcoholic fatty liver disease (NAFLD) is assumed, a leptin deficiency is also related to the development of NAFLD early in life in ob/ob mice, in patients with leptin deficiency due to biallelic likely pathogenic variants in the leptin gene, and in patients with lipodystrophy.ObjectivesTo investigate the association of circulating leptin levels in pre-pubertal children with obesity and steatosis hepatis.MethodsThe cross-sectional study consisted data of n=97 (nmale=76) pre-pubertal children (11.8 ± 1.5 years) with obesity (BMIz: 2.4 ± 0.4). Fasting concentrations of cardiometabolic parameters were measured: insulin, c-peptide, glucose, triglyceride, cholesterol, HDL, LDL, AST, ALT, GGT, leptin. Steatosis hepatis was diagnosed by an ultrasound examination (mild, moderate or severe). Patients were categorized into two groups: low z-score of circulating leptin levels (≤25th percentile) vs. normal z-score of circulating leptin levels.ResultsOne-third of the children with obesity were diagnosed with steatosis hepatis (I°: 63.6%, II°/III°: 36.4%). Children with steatosis hepatis had significantly lower z-scores of circulating leptin levels compared to children with an unremarkable liver ultrasonography (-2.1 ± 0.8 vs. -0.7 ± 0.6). Z-scores of circulating leptin levels correlate negatively with degree of steatosis hepatis. Children with low z-scores of circulating leptin levels had significantly higher triglyceride, fasting insulin and c-peptide levels compared to children with normal z-scores of circulating leptin levels.ConclusionPrepubertal children with NAFLD and obesity and partial leptin deficiency might be defined as a clinical subgroup.
Revealing the Critical Regulators of Modulated Smooth Muscle Cells in Atherosclerosis in Mice
Authors: Zhou Wenli , Bai Yongyi , Chen Jianqiao , Li Huiying , Zhang Baohua , Liu Hongbin 
Published: May 2022

Background: There are still residual risks for atherosclerosis (AS)-associated cardiovascular diseases to be resolved. Considering the vital role of phenotypic switching of smooth muscle cells (SMCs) in AS, especially in calcification, targeting SMC phenotypic modulation holds great promise for clinical implications.Methods: To perform an unbiased and systematic analysis of the molecular regulatory mechanism of phenotypic switching of SMCs during AS in mice, we searched and included several publicly available single-cell datasets from the GEO database, resulting in an inclusion of more than 80,000 cells. Algorithms implemented in the Seurat package were used for cell clustering and cell atlas depiction. The pySCENIC and SCENIC packages were used to identify master regulators of interested cell groups. Monocle2 was used to perform pseudotime analysis. clusterProfiler was used for Gene Ontology enrichment analysis.Results: After dimensionality reduction and clustering, reliable annotation was performed. Comparative analysis between cells from normal artery and AS lesions revealed that three clusters emerged as AS progression, designated as mSMC1, mSMC2, and mSMC3. Transcriptional and functional enrichment analysis established a continuous transitional mode of SMCs’ transdifferentiation to mSMCs, which is further supported by pseudotime analysis. A total of 237 regulons were identified with varying activity scores across cell types. A potential core regulatory network was constructed for SMC and mSMC subtypes. In addition, module analysis revealed a coordinate regulatory mode of regulons for a specific cell type. Intriguingly, consistent with gain of ossification-related transcriptional and functional characteristics, a corresponding small set of regulators contributing to osteochondral reprogramming was identified in mSMC3, including Dlx5, Sox9, and Runx2.Conclusion: Gene regulatory network inference indicates a hierarchical organization of regulatory modules that work together in fine-tuning cellular states. The analysis here provides a valuable resource that can provide guidance for subsequent biological experiments.