bluuebunny/crossref_metadata_2025_split huggingface dataset:
A descriptive assessment of a broad range of food-related parenting practices in a diverse cohort of parents of preschoolers using the novel Real-Time Parent Feeding Practices Survey
Authors: Loth K. A. , Ji Z. , Wolfson J. , Neumark-Sztainer D. , Berge J. M. , Fisher J. O. 
Published: March 2022

Abstract
Background
Much of the research to-date on food parenting has evaluated typical use of various parent feeding practices via questionnaire. The Real-Time Parent Feeding Practices Measurement survey was developed for use within an Ecological Momentary Assessment (EMA) protocol to capture momentary use of parent feeding practices in real-time.

Methods
This manuscript describes the development of the EMA-based Real-Time Parent Feeding Practices survey and highlights initial descriptive data on the real-time use of 22 individual parent feeding practices (e.g., pressure-to-eat, guided choices, etc.) as reported via EMA by parents of preschool-aged children (n = 116) over a 10-day data collection time period. A total of 3382 eating occasions were reported, with an average of 29.2 reported eating occasions per participant.

Results
Results revealed that most participants used a variety of food-related parenting practices day-to-day that span four higher-order domains: structure, autonomy support, coercive control and indulgence. Supportive feeding practices, defined as those from the structure and autonomy support domains, were reported most frequently, with one or more structure behavior (e.g., specific mealtime rules/routines) was used at 88.9% of reported eating occasions and one or more autonomy support behavior (e.g., involvement of the child in meal preparation) was used at 87.3% of eating occasions. While unsupportive feeding practices, defined as practices from within the coercive control (e.g., pressure-to-eat) and indulgent (e.g., anticipatory catering) feeding domains, were reported less frequently, one or more behaviors from each of these domains were still reported at over 25% of all eating occasions.

Conclusions
Results of the current study take a next step towards deepening our understanding of the use of a broad range of food-related parenting practices in real-time. Findings revealed that the vast majority of practices used by parents fall within the structure and autonomy support domains. However, most parents did not exclusively use supportive or unsupportive practices, rather they used a combination of food-related parenting practices across all domains. Future research should continue to explore a broad range of food-related parenting practices and seek to understand how parent approaches to feeding are associated with long-term child outcomes, including dietary intake, food preferences, and eating patterns.
Treatment regimens for neuromyelitis optica spectrum disorder attacks: a retrospective cohort study
Authors: Demuth Stanislas , Guillaume Maxime , Bourre Bertrand , Ciron Jonathan , Zephir Hélène , Sirejacob Yoann , Kerbrat Anne , Lebrun-Frenay Christine , Papeix Caroline , Michel Laure , Laplaud David , Vukusic Sandra , Maillart Elisabeth , Cohen Mikael , Audoin Bertrand , Marignier Romain , Collongues Nicolas ,   for the NOMADMUS Study Group
Published: March 2022

Abstract
Background
Neuromyelitis optica spectrum disorder (NMOSD) attacks require an urgent probabilistic anti-inflammatory therapeutic strategy. As inadequately treated attacks result in disability, there is a need to identify the optimal attack-treatment regimen. Our study aimed to identify predictors of outcome after a first attack in patients with an NMOSD presentation and propose the best treatment strategy.

Methods
We performed a retrospective cohort study on the French national NMOSD registry (NOMADMUS), a nested cohort of the French multiple sclerosis observatory (OFSEP) recruiting patients with NMOSD presentations in France. We studied the first attack for any independent locations of clinical core characteristic of NMOSD, in treatment-naïve patients. The primary outcome was the evolution of the Expanded Disability Status Scale (EDSS) score at 6 months, stratified in two ways to account for recovery (return to baseline EDSS score) and treatment response (classified as “good” if the EDSS score decreased by ≥ 1 point after a nadir EDSS score ≤ 3, or by ≥ 2 points after a nadir EDSS score > 3). We used ordinal logistic regression to infer statistical associations with the outcome.

Results
We included 211 attacks among 183 patients (104 with anti-AQP4 antibodies, 60 with anti-MOG antibodies, and 19 double seronegative). Attack treatment regimens comprised corticosteroids (n = 196), plasma exchanges (PE; n = 72) and intravenous immunoglobulins (n = 6). Complete recovery was reached in 40 attacks (19%) at 6 months. The treatment response was “good” in 134 attacks (63.5%). There was no improvement in EDSS score in 50 attacks (23.7%). MOG-antibody seropositivity and short delays to PE were significantly and independently associated with better recovery and treatment response.

Conclusions
We identified two prognostic factors: serostatus (with better outcomes among MOG-Ab-positive patients) and the delay to PE. We, therefore, argue for a more aggressive anti-inflammatory management of the first attacks suggesting an NMOSD presentation, with the early combination of PE with corticosteroids.
The comparative anti-cancer effects of krill oil and oxaliplatin in an orthotopic mouse model of colorectal cancer
Authors: Jayathilake Abilasha Gayani , Hassanzadeganroudsari Majid , Jovanovska Valentina , Luwor Rodney Brain , Nurgali Kulmira , Su Xiao Qun 
Published: March 2022

Abstract
Background
Our in vitro studies demonstrated that krill oil (KO) has anti-cancer potential. This study aimed to compare the anti-cancer effects of KO with a commonly used chemotherapeutic drug, oxaliplatin and to identify the molecular mechanisms associated with KO supplementation in a mouse model of colorectal cancer (CRC).

Methods
Thirty-six male Balb/c mice were randomly divided into six groups. Five groups received standard chow diet supplemented with KO (150 g/kg)), corn oil (150 g/kg), KO combined with ½ dose of oxaliplatin (1.5 mg/kg body weight/3 times per week), corn oil combined with ½ dose of oxaliplatin (1.5 mg/kg body weight/3 times per week), or a full dose of oxaliplatin (3 mg/kg body weight/3 times per week). The control (sham) group received a standard chow diet. Treatments started three weeks before and continued for three weeks after orthotopic CRC induction. The number of metastases, tumour weight and volume were quantified ex-vivo. The expression of cytochrome c, cleaved caspase-9 and -3, DNA damage, PD-L1, PD-L2 and HSP-70 were determined.

Results
A significant reductions in the weight and volume of tumours were observed in mice treated with KO and KO plus a ½ dose of oxaliplatin compared to the sham group, similar to oxaliplatin-treated mice. KO, and KO plus ½ dose of oxaliplatin significantly increased the expression of cytochrome c, cleaved caspase-9 and -3, and DNA damage and decreased expression of PD-L1, PD-L2 and HSP-70 in tumour tissues compared to the sham group.

Conclusions
The in vivo anti-cancer effects of KO are comparable with oxaliplatin. Thus, dietary KO supplementation has a great potential as a therapeutic/adjunctive agent for CRC treatment.
Partial p53 reactivation is sufficient to induce cancer regression
Authors: Klimovich Boris , Meyer Laura , Merle Nastasja , Neumann Michelle , König Alexander M. , Ananikidis Nikolaos , Keber Corinna U. , Elmshäuser Sabrina , Timofeev Oleg , Stiewe Thorsten 
Published: March 2022

Abstract
Background
Impaired p53 function is one of the central molecular features of a tumor cell and even a partial reduction in p53 activity can increase the cancer risk in mice and men. From a therapeutic perspective it is noteworthy that tumor cells often become addicted to the absence of p53 providing a rationale for developing p53 reactivating compounds to treat cancer patients. Unfortunately, many of the compounds that are currently undergoing preclinical and clinical testing fail to fully reactivate mutant p53 proteins, raising the crucial question: how much p53 activity is needed to elicit a therapeutic effect?

Methods
We have genetically modelled partial p53 reactivation using knock-in mice with inducible expression of the p53 variant E177R. This variant has a reduced ability to bind and transactivate target genes and consequently causes moderate cancer susceptibility. We have generated different syngeneically transplanted and autochthonous mouse models of p53-deficient acute myeloid leukemia and B or T cell lymphoma. After cancer manifestation we have activated E177R expression and analyzed the in vivo therapy response by bioluminescence or magnetic resonance imaging. The molecular response was further characterized in vitro by assays for gene expression, proliferation, senescence, differentiation, apoptosis and clonogenic growth.

Results
We report the conceptually intriguing observation that the p53 variant E177R, which promotes de novo leukemia and lymphoma formation, inhibits proliferation and viability, induces immune cell infiltration and triggers cancer regression in vivo when introduced into p53-deficient leukemia and lymphomas. p53-deficient cancer cells proved to be so addicted to the absence of p53 that even the low-level activity of E177R is detrimental to cancer growth.

Conclusions
The observation that a partial loss-of-function p53 variant promotes tumorigenesis in one setting and induces regression in another, underlines the highly context-specific effects of individual p53 mutants. It further highlights the exquisite sensitivity of cancer cells to even small changes in p53 activity and reveals that changes in activity level are more important than the absolute level. As such, the study encourages ongoing research efforts into mutant p53 reactivating drugs by providing genetic proof-of-principle evidence that incomplete p53 reactivation may suffice to elicit a therapeutic response.
PAciFy Cough—a multicentre, double-blind, placebo-controlled, crossover trial of morphine sulphate for the treatment of pulmonary Fibrosis Cough
Authors: Wu Zhe , Banya Winston , Chaudhuri Nazia , Jakupovic Ira , Maher Toby M. , Patel Brijesh , Spencer Lisa G. , Thillai Muhunthan , West Alex , Westoby John , Wijsenbeek Marlies , Smith Jaclyn , Molyneaux Philip L. 
Published: March 2022

Abstract
Background
Idiopathic pulmonary fibrosis (IPF) is a progressive disease that leads to lung scarring. Cough is reported by 85% of patients with IPF and can be a distressing symptom with a significant impact on patients’ quality of life. There are no proven effective therapies for IPF-related cough. Whilst morphine is frequently used as a palliative agent for breathlessness in IPF, its effects on cough have never been tested. PAciFy Cough is a multicenter, double-blind, placebo-controlled, crossover trial of morphine sulphate for the treatment of cough in IPF.

Methods
We will recruit 44 subjects with IPF prospectively from three interstitial lung disease units in the UK, namely the Royal Brompton Hospital, Manchester University NHS Foundation Trust (MFT) and Aintree University Hospital NHS Foundation Trust. Patients will be randomised (1:1) to either placebo twice daily or morphine sulphate 5 mg twice daily for 14 days. They will then crossover after a 7-day washout period. The primary endpoint is the percent change in daytime cough frequency (coughs per hour) from baseline as assessed by objective cough monitoring at day 14 of treatment.

Discussion
This multicentre, randomised trial will assess the effect of opioids on cough counts and cough associated quality of life in IPF subjects. If proven to be an effective intervention, it represents a readily available treatment for patients.

Trial registration
The study was approved by the UK Medicines and Healthcare Regulatory Agency (Ref: CTA 21268/0224/001-0001 – EUDRACT 2019-003571-19 – Protocol Number RBH2019/001) on 08 April 2020, in compliance with the European Clinical Trials Directive and the Medicines for Human Use (Clinical Trials) Regulations 2004 and its subsequent amendments. The study was provided with ethical approval by the London Brent Research Ethics Committee (Ref: 20/LO/0368) on 21 May 2020 and is registered with clinicaltrials.gov (NCT04429516) on 12 June 2020, available at https://clinicaltrials.gov/ct2/show/NCT04429516
Study protocol for the Multimodal Approach to Preventing Suicide in Schools (MAPSS) project: a regionally based randomised trial of an integrated response to suicide risk among secondary school students
Authors: Byrne Sadhbh J. , Bailey Eleanor , Lamblin Michelle , McKay Samuel , Pirkis Jane , Mihalopoulos Cathrine , Spittal Matthew J. , Rice Simon , Hetrick Sarah , Hamilton Matthew , Yuen Hok Pan , Lee Yong Yi , Boland Alexandra , Robinson Jo 
Published: March 2022

AbstractBackgroundSuicide is the leading cause of death among young Australians, accounting for one-third of all deaths in those under 25. Schools are a logical setting for youth suicide prevention activities, with universal, selective and indicated approaches all demonstrating efficacy. Given that international best practice recommends suicide prevention programmes combine these approaches, and that to date this has not been done in school settings, this study aims to evaluate a suicide prevention programme incorporating universal, selective and indicated components in schools.MethodsThis study is a trial of a multimodal suicide prevention programme for young people. The programme involves delivering universal psychoeducation (safeTALK) to all students, screening them for suicide risk, and delivering internet-based Cognitive Behavioural Therapy (Reframe IT) to those students identified as being at high risk for suicide. The programme will be trialled in secondary schools in Melbourne, Australia, and target year 10 students (15 and 16 year-olds). safeTALK and screening will be evaluated using a single group pre-test/post-test case series, and Reframe IT will be evaluated in a Randomised Controlled Trial. The primary outcome is change in suicidal ideation; other outcomes include help-seeking behaviour and intentions, and suicide knowledge and stigma. The programme’s cost-effectiveness will also be evaluated.DiscussionThis study is the first to evaluate a suicide prevention programme comprising universal, selective and indicated components in Australian schools. If the programme is found to be efficacious and cost-effective, it could be more widely disseminated in schools and may ultimately lead to reduced rates of suicide and suicidal behaviour in school students across the region.
Establishment of bovine 3D enteroid-derived 2D monolayers
Authors: Sutton Kate M. , Orr Brigid , Hope Jayne , Jensen Stina R. , Vervelde Lonneke 
Published: March 2022

AbstractThree-dimensional (3D) intestinal enteroids are powerful in vitro models for studying intestinal biology. However, due to their closed structure direct access to the apical surface is impeded, limiting high-throughput applications of exogenous compounds and pathogens. In this study, we describe a method for generating confluent 2D enteroids from single-cell suspensions of enzymatically-dissociated ileum-derived bovine 3D enteroids. Confluent monolayers were first achieved using IntestiCult media but to establish a defined, cost-effective culture media, we also developed a bovine enteroid monolayer (BEM) medium. The monolayers cultured in BEM media proliferated extensively and formed confluent cell layers on both Matrigel-coated plastic plates and transwell inserts by day 3 of culture. The 2D enteroids maintained the epithelial cell lineages found in 3D enteroids and ileum tissue. In addition, the monolayers formed a functional epithelial barrier based on the presence of the adherens and tight junction proteins, E-cadherin and ZO-1, and electrical resistance across the monolayer was measured from day 3 and maintained for up to 7 days in culture. The method described here will provide a useful model to study bovine epithelial cell biology with ease of access to the apical surface of epithelial cells and has potential to investigate host–pathogen interactions and screen bioactive compounds.
Microwave wireless power transmission technology index system and test evaluation methods
Authors: Wang Changfu , Xu Wanli , Zhang Chunlin , Wang Mengyi , Wang Xudong 
Published: March 2022

AbstractMicrowave wireless power transmission technology has broad application prospects in improving the endurance and range of unmanned equipment. It is also of great significance in the field of the Internet of things, which can effectively solve the problem of energy supply for devices in the Internet of things. In addition, using vehicle-mounted microwave wireless power transmission to power multi-objective unmanned aerial vehicle swarms and to build an air-ground integrated power transmission network. In this study, the corresponding technical index system and test evaluation methods, which are conducive to promoting the development and progress of this technology, were established. The topology of a microwave wireless power transmission system was analyzed, and technical evaluation indices were developed for microwave wireless power transmission systems, signal generators, power amplifiers, transceiver antennas, and rectifier circuits. Test evaluation methods were established consisting of test equipment, methods, and processes to provide powerful technical means for the development of microwave wireless power transmission systems.
A new method of identifying key industries: a principal component analysis
Authors: Tsoulfidis Lefteris , Athanasiadis Ioannis 
Published: March 2022

AbstractThis article using the principal components analysis identifies key industries and groups them into particular clusters. The data come from the US benchmark input–output tables of the years 2002, 2007, 2012 and the most recently published input–output table of the year 2019. We observe some intertemporal switches of industries both between and within the top clusters. The findings further suggest that structural change is a slow-moving process and it takes time for some industries to move from one cluster to the other. This information may be proved important in the designation of effective economic policies by targeting key industries and also for the stability properties of the economic system.
The leading role of perception: the FACOPA model to comprehend innovation adoption
Authors: Vecchio Yari , De Rosa Marcello , Pauselli Gregorio , Masi Margherita , Adinolfi Felice 
Published: March 2022

AbstractIn this work, we explore the link between the perception of complexity and the possibility of adopting precision agricultural tools (PATs). Many studies have analysed the role of perception, mostly considering it a determinant of adoption on the same level as other contextual factors. In contrast, this study contributes by assuming that farmers' perceived complexity is the main factor influencing their propensity to innovate and should be analysed on a different level. Starting from this assumption, a new theoretical model is proposed with the aim of studying the “factors–perception of complexity–adoption” (FACOPA) process. To test the validity of our hypothesis, a survey is conducted based on a purposive sample of 285 farmers. First, a linear regression model permits us to identify determinants of the perception of complexity. Then, a multinomial logistic model is used to determine which aspects of perceived complexity may affect the choice to adopt precision farming tools made by three different types of agricultural entrepreneurs: adopters, non-adopters, and planners. First, the linear regression results show that socio-structural variables have a logical relationship with perceived complexity, with age, farm size, the intensity of information and the intensity of work being significant. Then, the multinomial logistic model highlights that non-adopters perceive almost all aspects of complexity as barriers to adoption. Planners show a lower perception of complexity than non-adopters, with complexity being determined by financial and network aspects. The results provide interesting suggestions for policy-makers. Indeed, the FACOPA model offers insights into an intervention framework in which policy measures can be diversified to disseminate PATs based on farmer categories. Non-adopters require a broader set of policy instruments, while planners should be encouraged to become adopters through financial support and the activation of innovation networks.
Longitudinal measurement of growth in vocabulary size using Rasch-based test equating
Authors: Akase Masaki 
Published: March 2022

AbstractThe purpose of this study is to equate and further validate three forms of the vocabulary size test (VST) created by Aizawa and Mochizuki (2010). These three forms, VST 1, 2, and 3, were administered to a cohort of 189 high school students ranging in age from 16 to 18 in April of their 1st, 2nd, and 3rd year of high school. Although these alternate forms were designed to be of equal difficulty, formal equating of the three forms was never carried out. In order to verify whether gains in test scores were due to growth in vocabulary size or differences in difficulty among the three forms, a fourth form comprised of items selected from VST 1–3 was created and administered in December of year 3. The four test forms were then equated using Rasch analysis, placing persons and items on a single, uniform logit scale. The results indicated that (1) the three original forms of the VST all showed good fit to the Rasch model, (2) differences in test difficulty among the original three forms were minor, and (3) the four VST forms, linked via a single Rasch analysis, can be appropriately used for estimating gains in students’ VS across their high school career. In addition, follow-up analyses indicated considerable overlap in item difficulty among word frequency bands, suggesting that word frequency was not the sole indicator of difficulty of vocabulary items, and that learner progress in vocabulary learning tended to be uniform and parallel across all frequency bands. Overall, the study illustrates a method for creating a valid and reliable measure of growth in VS over an extended period of time and provides insight into the relationships among word frequency, word difficulty, and progress in vocabulary learning.
Laser ablation inductively coupled plasma mass spectrometry analysis of potash and m-Na-Al glasses in China- using Kernel methods for trace element analysis
Authors: Ma Qian , Pollard A. Mark , Yu Yifan , Li Zhuanjie , Liao Linling , Wang Long , Li Man , Cai Luwu , Ping Li , Wen Rui 
Published: March 2022

Abstract
Monochrome drawn beads were widely circulated in South and Southeast Asia as early as the second century BC. This article aims to identify the glass beads unearthed from different sites in China and discuss their possible sources. Twenty-seven mineral soda alumina (m-Na-Al) glass and eighty-seven potash glass beads unearthed in different provinces in China were analysed by Laser Ablation Inductively Coupled Plasma Mass Spectrometry. The trace element analysis through Multivariate Kernel Density Estimation and Maximum Mean Discrepancy indicates the silica sources of m-Na-Al glass and most of the potash glass unearthed from Guangxi are identical. They were presumably produced somewhere in northeastern India or Southeast Asia and exported through the Maritime Silk Road. The silica sources of m-Na-Al glass in Henan and the rest of the potash glasses are geologically close. They were likely produced in southern India or Sri Lanka and exported through the North and Southwest Silk Roads. Future research on isotopic analysis will reveal more information about primary/secondary glass production in China, South and Southeast Asia.