bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracer‐specific reference tissues selection improves detection of 18F‐FDG, 18F‐florbetapir, and 18F‐flortaucipir PET SUVR changes in Alzheimer's disease
Authors: Li Yanxiao , Ng Yee Ling , Paranjpe Manish D. , Ge Qi , Gu Fengyun , Li Panlong , Yan Shaozhen , Lu Jie , Wang Xiuying , Zhou Yun ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: February 2022

AbstractThis study sought to identify a reference tissue‐based quantification approach for improving the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies. A total of 794, 906, and 903 scans were included for 18F‐FDG, 18F‐florbetapir, and 18F‐flortaucipir, respectively. Positron emission tomography (PET) and T1‐weighted images of participants were collected from the Alzheimer's disease Neuroimaging Initiative database, followed by partial volume correction. The standardized uptake value ratios (SUVRs) calculated from the cerebellum gray matter, centrum semiovale, and pons were evaluated at both region of interest (ROI) and voxelwise levels. The statistical power of reference tissues in detecting longitudinal SUVR changes was assessed via paired t‐test. In cross‐sectional analysis, the impact of reference tissue‐based SUVR differences between cognitively normal and cognitively impaired groups was evaluated by effect sizes Cohen's d and two sample t‐test adjusted by age, sex, and education levels. The average ROI t values of pons were 86.62 and 38.40% higher than that of centrum semiovale and cerebellum gray matter in detecting glucose metabolism decreases, while the centrum semiovale reference tissue‐based SUVR provided higher t values for the detection of amyloid and tau deposition increases. The three reference tissues generated comparable d images for 18F‐FDG, 18F‐florbetapir, and 18F‐flortaucipir and comparable t maps for 18F‐florbetapir and 18F‐flortaucipir, but pons‐based t map showed superior performance in 18F‐FDG. In conclusion, the tracer‐specific reference tissue improved the detection of 18F‐FDG, 18F‐florbetapir, and 18F‐flortaucipir PET SUVR changes, which helps the early diagnosis, monitoring of disease progression, and therapeutic response in Alzheimer's disease.
The safety and clinical effectiveness of rapid infusion with CT‐P10 in patients with non‐Hodgkin's lymphoma or chronic lymphocytic leukemia: A retrospective non‐interventional post‐authorization safety study in Europe
Authors: Bishton Mark , Marshall Scott , Harchowal Jatinder , Salles Gilles , Golfier Camille , Tucci Alessandra , Fernández Alicia Rodriguez , Sanchez Blanco Jose Javier , Bocchia Monica , Kim SooKyoung , Lee Young Nam , Zinzani Pier Luigi 
Published: February 2022

AbstractRapid infusion (RI) of the rituximab biosimilar CT‐P10 is currently only an approved treatment regimen for the treatment of rheumatoid arthritis. Although both CT‐P10 and reference rituximab are known to be frequently administered using a RI regimen (≤90 min) in clinical practice, published data on the safety of RI of CT‐P10 in patients with NHL and CLL are limited. Hence, this study collected real‐world safety and effectiveness data on RI‐CT‐P10 from the medical records of 196 patients with NHL or CLL in 10 European centers, 6 months after the date of the first RI (index date); the infusion‐related reaction (IRR) rate was compared to previously published data. Ten percent (95% confidence interval 6%–15%; n = 20/196) of patients experienced an infusion‐related reaction (IRR) on day 1–2 post‐index, which was not significantly different (p = 0.45) to the IRR rate for rituximab described in a previous meta‐analysis (8.8%). During the observation period, 2% of patients experienced grade 3–5 IRRs and 85% (n = 166) experienced an adverse event (non‐IRR). The most common reason for discontinuation of first‐line CT‐P10 was planned treatment completion (81%; n = 158). Complete response and partial response to CT‐P10 was observed in 74% (n = 142/192) and 22% (n = 42/192) of patients, respectively. The results of this real‐world study demonstrate that the safety and effectiveness profile of RI‐CT‐P10 is similar to RI of reference rituximab and therefore support the current use of RI‐CT‐P10 in patients with NHL and CLL.
Economic policy uncertainty and stock markets’ co‐movements
Authors: Albrecht Peter , Kapounek Svatopluk , Kučerová Zuzana 
Published: February 2022

AbstractHere, we investigate the direction of the relationship between economic policy uncertainty (EPU) and stock markets. We focus on time‐variant co‐movements between the EPU index and selected stock market indices (S&P500, UK100, Nikkei225 and DAX30) at different investment horizons. We show that the EPU index lags stock markets at longer investment horizons during global financial turmoil, especially in the United States, Japan and Germany. The identified lag between the changes of the EPU index and selected stock market indices ranges between 2 and 6 months at investment horizons exceeding 32 months. In addition, we confirm the existence of the short‐term effects of EPU on stock markets.
Modeling of linear alkyl benzene sulphonic acid removal from aqueous solution with fixed bed adsorption column: Thomas and Yoon–Nelson methods
Authors: Belat Begum , Veli Sevil , Isgoren Melike 
Published: February 2022

AbstractBACKGROUNDIn Turkey, which is one of the world's top walnut producers, the volume of waste shell has increased in recent years as a result of escalating consumption. Globally, including in Turkey, cleaning products are the leading pollutants entering the aquatic environment. This study aimed to address both issues, by investigating the removal of Linear Alkyl Benzene Sulphonic Acid synthetic solution through a fixed‐bed adsorption column system embedded with the composite of a polyaniline‐supported activated walnut shell.RESULTSLinear Alkyl Benzene Sulfonic Acid removal efficiency was evaluated in terms of detergent and chemical oxygen demand (COD) parameters. Column performance increased with low flow rate, increased bed height and high inlet concentration. Optimum conditions were determined as 7.5 cm bed height, 10 mL min−1 flow rate, and 30 mg L−1 inlet solution concentration. Thomas and Yoon–Nelson models were applied to experimental data to estimate the column adsorption behavior. The Yoon–Nelson model (R2 > 0.9) seemed fit to explain the adsorption column behavior. To understand the reuse capacity of the adsorbent a regeneration study was carried out, showing that the maximum adsorption capacity of the adsorbent (qtotal) decreased from 216 mg g−1 before regeneration to 6.4 mg g−1 after the third regeneration cycle.CONCLUSIONThis adsorbent has a high potential for detergent and COD adsorption from anionic aqueous solutions, and would be a good alternative for a pretreatment step. © 2022 Society of Chemical Industry (SCI).
Seabird stress and breeding: Endocrine and hematological stress biomarkers differ between gray‐faced petrel (Pterodroma gouldi) colonies
Authors: Whitehead Edin A. , Russell James C. , Hickey Anthony J. , Taylor Graeme A. , O'Reilly Katie M. , Della Penna Alice , Dunphy Brendon J. 
Published: February 2022

AbstractSeabird breeding success is known to reflect oceanic conditions. Gray‐faced petrels (Pterodroma gouldi) breeding on the east coast of Auckland, New Zealand, exhibit poor reproductive success and slow chick development compared to west coast conspecifics. This study mapped changes in physiological traits (corticosterone [CORT] and hematological parameters) indicative of sublethal stress in this Procellariiform species between the west coast (Ihumoana) and east coast (Hāwere) island colonies. We found adult gray‐faced petrels on the east coast to be lighter and, unlike west coast birds, exhibited an attenuation of response CORT levels between incubation and chick‐rearing phases. Such responses were also reflected in east coast chicks that were lighter and had higher feather CORT titers than west coast chicks. Measures of adult hematology and plasma biochemistry revealed significantly lower glucose levels in east coast birds and indicated that chick rearing is the most stressful phase of breeding for this species Combined; these results suggest that east coast birds are under greater nutritional stress and that parents appear to transfer the costs of poor foraging to their chicks to preserve their own condition, consequently increasing chick developmental stress. Our results suggest that any long‐term decrease in ocean conditions and/or climatic shifts would be more acutely felt by east coast chicks and potentially their parents, resulting in years of poor breeding success rates on a local scale.
Phase Ib study of avadomide (CC‐122) in combination with rituximab in patients with relapsed/refractory diffuse large B‐cell lymphoma and follicular lymphoma
Authors: Nastoupil Loretta J. , Kuruvilla John , Chavez Julio C. , Bijou Fontanet , Witzig Thomas E. , Santoro Armando , Flinn Ian W. , Boccomini Carola , Kenkre Vaishalee P. , Corradini Paolo , Isufi Iris , Andorsky David J. , Klein Leonard M. , Greenwald Daniel R. , Sangha Randeep , Shen Frank , Hagner Patrick , Li Yan , Dobmeyer Juergen , Gong Nian , Uttamsingh Shailaja , Pourdehnad Michael , Ribrag Vincent 
Published: February 2022

AbstractThe multicenter, phase Ib CC‐122‐DLBCL‐001 dose‐expansion study (NCT02031419) explored the cereblon E3 ligase modulator (CELMoD) agent avadomide (CC‐122) plus rituximab in patients with relapsed/refractory (R/R) diffuse large B‐cell lymphoma (DLBCL) or follicular lymphoma (FL). Patients received avadomide 3 mg/day 5 days on/2 days off plus rituximab 375 mg/m2 on day 8 of cycle 1, day 1 of cycles 2 through 6, and day 1 of every third subsequent cycle for 2 years. Primary endpoints were safety and tolerability; preliminary efficacy was a secondary endpoint. A total of 68 patients were enrolled (DLBCL [n = 27], FL [n = 41; 31 lenalidomide‐naïve, 10 lenalidomide‐treated]). Median age was 62 years (range, 33–84 years), and patients had received a median of 3 (range, 1–8) prior regimens. Among patients with DLBCL, 66.7% had primary refractory disease (partial response or less to initial therapy). Among patients with FL, 65.9% were rituximab‐refractory at study entry and 10.0% were lenalidomide‐refractory. The most common any‐grade avadomide‐related adverse events (AEs) were neutropenia (63.2%), infections/infestations (23.5%), fatigue (22.1%), and diarrhea (19.1%). The most common grade 3/4 avadomide‐related AEs were neutropenia (55.9%) infections/infestations (8.8%), and febrile neutropenia (7.4%). In patients with DLBCL, overall response rate (ORR) was 40.7% and median duration of response (mDOR) was 8.0 months. In patients with FL, ORR was 80.5% and mDOR was 27.6 months; response rates were similar in lenalidomide‐naïve and ‐treated patients. Avadomide plus rituximab was well tolerated, and preliminary antitumor activity was observed in patients with R/R DLBCL and FL, including subgroups with typically poor outcomes. These results support further investigation of novel CELMoD agents in combination with rituximab in R/R DLBCL and FL.
Flavonoids improve the stability and function of P23H rhodopsin slowing down the progression of retinitis pigmentosa in mice
Authors: Ortega Joseph Thomas , Parmar Tanu , Carmena‐Bargueño Miguel , Pérez‐Sánchez Horacio , Jastrzebska Beata 
Published: February 2022

AbstractThe balanced homeostasis of the G protein–coupled receptor (GPCR), rhodopsin (Rho), is required for vision. Misfolding mutations in Rho cause photoreceptor death, leading to retinitis pigmentosa (RP) and consequently blindness. With no cure currently available, the development of efficient therapy for RP is an urgent need. Pharmacological supplementation with molecular chaperones, including flavonoids, improves stability, folding, and membrane targeting of the RP Rho mutants in vitro. Thus, we hypothesized that flavonoids by binding to P23H Rho and enhancing its conformational stability could mitigate detrimental effects of this mutation on retinal health. In this work, we evaluated the pharmacological potential of two model flavonoids, quercetin and myricetin, by using in silico, in vitro, and in vivo models of P23H Rho. Our computational analysis showed that quercetin could interact within the orthosteric binding pocket of P23H Rho and shift the conformation of its N‐terminal loop toward the wild type (WT)‐like state. Quercetin added to the NIH‐3T3 cells stably expressing P23H Rho increased the stability of this receptor and improved its function. Systemic administration of quercetin to P23H Rho knock‐in mice substantially improved retinal morphology and function, which was associated with an increase in levels of Rho and cone opsins. In addition, treatment with quercetin resulted in downregulation of the UPR signaling and oxidative stress‐related markers. This study unravels the pharmacological potential of quercetin to slow down the progression of photoreceptor death in Rho‐related RP and highlights its prospective as a lead compound to develop a novel therapeutic remedy to counter RP pathology.
Genetic and seasonal variability of bioactive polyphenolic compounds and antioxidant‐based phytonutrient promise of diverse vegetable amaranths of Indo‐Gangetic plains of West Bengal
Authors: Sen Debasmita , Bhattacharjee Soumen 
Published: February 2022

AbstractBackgroundThough vegetable amaranths harbor good pool of phenolic compounds, but till date, there is no systematic database on seasonal and genetic diversity based antioxidant‐dependent phytonutrient promise of amaranths of Gangetic plains of West Bengal particularly those derived from chalcone and cinnamic acids of phenyl propanoid metabolism and hence is the subject of present investigation.ResultsA comparative evaluation based on RP‐HPLC (Reverse Phase‐High Performance Liquid Chromatography) coupled photodiode assay of twenty one pharmacologically important bioactive polyphenolic compounds (flavonoids and phenolic acids) along with sensitive biomarkers of antioxidant properties (reducing property, metal chelating property, superoxide radical scavenging property, hydroxyl radical scavenging property, antilipid peroxidation, anti‐inflammatory property, and antidiabetic property) has been done for the assessment of genotype‐based seasonal variation of antioxidant‐based phytonutrient promise of vegetable amaranths of Indo‐Gangetic plains of West Bengal. The work exhibited genotype‐specific accumulation of bioactive polyphenolic compounds and associated antioxidant properties, with A. hypochondriacus L. exhibiting significantly greater abundance of majority of polyphenolic compounds tested, followed by A. viridis L. and A. hybridus L. The work also recorded the genotype‐specific seasonal elicitation of the synthesis of bioactive polyphenolic compounds.ConclusionTaken as a whole, the work suggests genotype‐specific seasonal variations in the accumulation of bioactive polyphenolic compounds and antioxidant‐based phytonutrient promise in diverse amaranth germplasms of Gangetic plain of West Bengal and identified lead germplasms as low‐cost antioxidant supplement for utilization in crop diversification program.
Effect of pulping methods on the physicochemical properties of the Kenyan red and white‐fleshed guava pulp
Authors: Omayio Duke G. , Abong' George O. , Okoth Michael W. , Gachuiri Charles K. , Mwang'ombe Agnes W. 
Published: February 2022

AbstractBackgroundAlthough fruit pulping is a highly effective global practice for ensuring a steady supply of fruit for processing during the off‐season, industrial pulping of Kenyan guava cultivars is lacking, contributing to their annual losses. The present study compared the yield characteristics, physicochemical profile, and nutrient retention of pulp extracted from white and red‐fleshed Kenyan guavas using cold and hot extraction methods.ResultsThe pulp yield was highest in the red guava with the pulp to by‐product ratio being significantly (p < 0.05) higher at 2.58, 2.97, and 3.30 for cold, hot water, and steam‐blanched compared to 1.66, 1.95, and 2.03 for the white guava respectively. Although hot extraction methods resulted in significantly (p < 0.0001) higher yields (67%–77%) compared to the cold (62%–73%), the heat‐labile nutrients were affected with as much as 60% and 64% of the white and the red guava's vitamin C being lost. The steam blanched pulps exhibited significantly (p < 0.0001) high overall color changes (∆E) ranging from 22–30 in the pasteurized white guava pulp compared to the red's (−0.24–6). The cold extraction method resulted in better retention of β‐carotene (1.9 ± 0.4 mg), zinc (5.6 ± 2.1 mg), iron (20.1 ± 8.6 mg), flavonoids (241.3 ± 56mgCE), phenolics (1548.7 ± 25.8mgGAE) and antioxidant activities (1998.6 ± 333μMTE) per 100 g in the red guava pulp.ConclusionCompared to the white cold‐extracted pulp, the red guava pulp was more suitable for further processing due to its high nutrient retention, high pulp to by‐products ratio, and textural properties therefore recommended for the adoption of processing the Kenyan guava cultivars.
Radiological Findings in Laryngeal Anterior Commissure Invasion: CT Scan Highlights
Authors: Cristalli Giovanni , Vidiri Antonello , Mercante Giuseppe , Ferreli Fabio , De Virgilio Armando , Donelli Filippo , Davì Luigi , Gasparin Pierpaola , Cocco Patrizia , Giudici Fabiola , Boscolo Nata Francesca 
Published: February 2022

ObjectivesPreoperative anterior commissure (AC) evaluation in glottic cancer is crucial for therapeutic decisions. Endoscopy is often inadequate to precisely detect the presence of cancer in the AC; thus, computed tomography (CT) scan could help. We investigated the relation between AC thickness on CT scan (in mm), AC involvement by cancer at histology, and radiologic signs of anterior paraglottic space (PGS) infiltration.Study DesignRetrospective observational study.MethodsAn experienced radiologist retrospectively measured AC thickness and identified signs of anterior PGS infiltration on pretreatment contrast‐enhanced CT scans of 80 patients with primary glottic cancer. The gold standard to define the presence of cancer in the AC was histology. The receiver operating characteristic (ROC) curves were used to determine the potential cut‐off values of AC thickness (Youden index method) able to maximize both sensitivity and specificity in identifying the presence of cancer in the AC at histology and PGS infiltration on CT scan.ResultsAC was significantly thicker in patients with cancer in the AC at histology (P < .001) and in patients with PGS infiltration on CT scan (P < .001). The cut‐off values to discriminate the presence of cancer at histology and PGS infiltration on CT scan were 3.62 and 2.6 mm, respectively. We found a substantial agreement between anterior PGS infiltration on CT scan and the presence of cancer in the AC at histology (Cohen Kappa: P = .70).ConclusionAC thickness and radiologic signs of PGS infiltration on pretreatment CT scan could represent a method to predict the presence of cancer in the AC at histology.Level of Evidence4 Laryngoscope, 132:2427–2433, 2022
Terpyridine‐Based 3D Discrete Metallosupramolecular Architectures
Authors: Yu Xiujun , Guo Chenxing , Lu Shuai , Chen Zhi , Wang Heng , Li Xiaopeng 
Published: February 2022

AbstractTerpyridine (tpy)‐based 3D discrete metallosupramolecular architectures, which are often inspired by polyhedral geometry and the biological structures found in nature, have drawn significant attention from the community of metallosupramolecular chemistry. Because of the linear tpy–M(II)–tpy connectivity, the creation of sophisticated 3D metallosupramolecules based on tpy remains a formidable synthetic challenge. Nevertheless, with recent advancement in ligand design and self‐assembly, diverse 3D metallosupramolecular polyhedrons, such as Platonic solids, Archimedean solids, prims as well as Johnson solids, have been constructed and their potential applications have been explored. This review summarizes the progress on tpy‐based discrete 3D metallosupramolecules, aiming to shed more light on the design and construction of novel discrete architectures with molecular‐level precision through coordination‐driven self‐assembly.
A microwave system based on a UWB microstrip antenna for non‐invasive in vitro measurement of glycemia in human blood: An experimental study
Authors: El Hassani Oumaima , Saadi Adil 
Published: February 2022

AbstractThe current study focuses on a non‐invasive microwave system based on a UWB antenna for blood glucose measurements in the frequency range of 1–4 GHz. Calculations of the minimal values of microwave reflection coefficient (S11 Min) corresponding to various blood glycemia, as well as comparisons to measured values using the Vector Network Analyzer Anritsu MS46121B, were the major findings of this study. The results were in good agreement, with a shift of less than 5%, demonstrating the effectiveness of our microwave method in detecting blood glycemia. To define an experimental approach between blood and dextrose solution, a comparative study in terms of slops in a linear approximation of both S11 Min and resonant frequency versus glucose concentration for the two mediums was interesting. The deviations in the results are less than 5% in the range of 1–2 GHz. However, it is not the case in the ranges of 2–3 GHz and 3–4 GHz since the two mediums show contrary behavior regarding S11 Min and resonant frequency. Consequently, D‐Solution might be used to simulate blood using our system for the investigation of glycemia only in the range of 1–2 GHz.
In situ monitoring of sandwich structure in liquid composite molding process using multifunctional MXene/carbon nanotube sensors
Authors: Zhang Lu , Lu Yao , Lu Shaowei , Wang Xiaoqiang , Ma Chengkun , Ma Keming 
Published: February 2022

AbstractThis paper prepares a flexible MXene/CNT film by layer‐by‐layer (LbL) self‐assembly process. Based on excellent conductivity and good compatibility with resin, MXene/CNT can be used for on‐line monitoring of large and complex liquid composite molding (LCM). In this paper, the MXene/CNT will be used as a novel micro‐nano sensor. The MXene/CNT sensor is embedded between the sandwich layers of the sandwich composite structure. The resistance information of the MXene/CNT sensor was collected by online monitoring system during LCM. The tube cross‐linked network's conductive model will be established to reveal the resistance response sensing mechanisms of MXene/CNT sensors and the response rules of resin flow states and resistance signals. Using the real‐time monitoring information collected by the MXene/CNT sensor, combined with Darcy's law, the comparison results of different permeability are obtained. The monitoring results show that polyvinyl chloride (PVC) interlayer significantly influences the resin flow trend and penetration of the core layer. Simultaneously, the interlayer's presence will also affect the resin flow trend and penetration of the lower layer of the PVC sandwich layer. The research results will provide theoretical guidance and technical support for designing process parameters and in situ real‐time monitoring of LCM in the engineering industry.