bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of disorder in multi-component covalent organic frameworks
Authors: Wolpert Emma , Tarzia Andrew , Jelfs Kim 
Published: December 2022

Abstract
The discovery of 2-dimensional (2D) covalent organic framework (COF) solid solutions enables the engineering of pore sizes as a function of linker ratio. However, how the components are distributed within the COF lattice may determine the degree of control over porosity for targeted applications. Here, we examined the effect of linker distribution on three multi-component COFs containing linkers that differ in length. We looked at how two different types of linker distribution affect the pore size and shape within single-layers of the COF: (i) randomly distributed linkers and (ii) when there is some correlation between the linker distribution. We were able to reveal a relationship between linker distribution and the properties seen in COF solid solutions. Moreover, the method used to produce the disordered structures presented in this paper is generalisable and could be used in further studies to examine the properties of disordered COFs.
A green, efficient and economical polypeptide - modified bamboo fiber and its application in glycopeptide antibiotics adsorption
Authors: Zhou Xiaoqian , Guo Dandan , Huang Shaohua , Zhao Yufen 
Published: December 2022

Abstract

Inspired by wet-cool/dry-hot cycle drived prebiotic reactions, a green and efficient dry-wet cycle modification method was proposed for the preparation of polypeptide-modified bamboo fiber (P-MBF). Functionalization of P-MBF was characterized by Fourier transform infrared spectroscopy, X-ray diffraction, element analysis and scanning electron microscopy. Compared to raw bamboo fiber materials, P-MBF showed better dispersibility in aqueous solutions, and thus exhibited better adsorption performance for glycopeptide antibiotics in sewage treatment. With vancomycin as the target antibiotic, adsorption performance of P-MBF was studied in aqueous solution. Adsorption kinetics and isotherms were well correlated with pseudo-second-order model and Langmuir model, respectively. Investigation of thermodynamic parameters implied that the adsorption was a spontaneous exothermic process. The adsorption efficiencies in standard solution and drinking water were 97.83% and 91.32% , respectively. This study provides a green, efficient and economical modified bamboo fiber material for the removal of glycopeptide antibiotics from sewage samples.
“Day or night, no matter what, I will go”: Women’s perspectives on challenges associated with receiving follow-up after abnormal cervical cancer screening results in Iquitos, Peru: a qualitative study
Authors: Morse Rachel M. , Jurczuk Magdalena , Brown Joanna , Carrillo Lita , Meza Graciela , López Jennifer Ríos , Gravitt Patti E. , Tracy J. Kathleen , Paz-Soldan Valerie A. 
Published: December 2022

Abstract
Background: The study’s objective was to explore the factors associated with loss to follow up among women with abnormal cervical cancer screening results in Iquitos, Peru from women’s perspectives.
Methods: In-depth interviews were conducted with 20 screen-positive women who were referred for follow-up care but for whom evidence of follow up was not found.
Results: All interviewed women were highly motivated to complete the continuum of care but faced numerous barriers along the way, including cognitive barriers such as a lack of knowledge about cervical cancer and poor communication from health professionals regarding the process, structural barriers such as challenges with scheduling appointments and unavailability of providers, and financial barriers including out-of-pocket payments and costs related to travel or missing days of work. With no registry to ensure the continuum of care, we found fragmentation between primary and hospital-level care, and often, registration of women’s follow up care was missing altogether, preventing women from being able to receive proper care and providers from ensuring that women receive care and treatment as needed.
Conclusions: The challenges elucidated demonstrate the complexity of implementing a successful cervical cancer prevention program and indicate a need for any such program to consider the perspectives of women and multiple levels in the system to improve follow up after a positive screening test.
Optimizing Detection of Clinically Significant Prostate Cancer through Nomograms incorporating MRI, Clinical Features, and Advanced Serum Biomarkers
Authors: Siddiqui Mohammad , Siddiqui Mohammad , Li Eric , Kumar Sai , Busza Anna , Lin Jasmine , Mahenthiran Ashorne , Aguiar Jonathan , Shah Parth , Ansbro Brandon , Rich Jordan , Solima Moataz , Keeter Mary-Kate , Mai Quan , Mi Xinlei , Tosoian Jeffrey , Schaeffer Edward , Patel Hiten , Ross Ashley 
Published: December 2022

Abstract

Purpose
To develop nomograms that predict the detection of clinically significant prostate cancer at diagnostic biopsy based on multiparametric prostate MRI (mpMRI), serum biomarkers, and patient clinicodemographic features.
Materials and Methods
Nomograms were developed from a cohort of biopsy-naïve men presenting to our 11-hospital system with a PSA of 2-20ng/mL who underwent pre-biopsy mpMRI from March 2018-June 2021 (n = 1494). The outcomes were the presence of clinically significant and high-grade prostate cancer (defined as ≥ GG2 [Grade Group 2] and ≥ GG3 prostate cancer, respectively). Using significant variables on multivariable logistic regression, individual nomograms were developed for men with PSA, % free PSA, or prostate health index (PHI) when available. The nomograms were both internally validated and evaluated in an independent cohort of 366 men presenting to our hospital system from July 2021-February 2022.
Results
1031 of 1494 men (69%) underwent biopsy after initial evaluation with mpMRI, 493 (47.8%) of whom were found to have ≥ GG2 PCa, and 271 (26.3%) were found to have ≥ GG3 PCa. Age, race, highest PIRADS score, prostate health index (PHI) when available, % free PSA when available, and PSA density were significant predictors of ≥ GG2 and ≥ GG3 PCa on multivariable analysis and were used for nomogram generation. Accuracy of nomograms in both the training cohort and independent cohort were high, with areas under the curves (AUC) of ≥ 0.885 in the training cohort and ≥ 0.896 in the independent validation cohort. In our independent validation cohort, our model for ≥ GG2 prostate cancer with PHI saved 39.1% of biopsies (143/366) while only missing 0.8% of csPCa (1/124) with a biopsy threshold of 20% probability of csPCa.
Conclusions
Here we developed nomograms combining serum testing and mpMRI to help clinicians risk stratify patients with elevated PSA of 2-20ng/mL who are being considered for biopsy. Our nomograms are available at https://rossnm1.shinyapps.io/MynMRIskCalculator/ to aid with biopsy decisions.
Carrier frequency of SMA by quantitative analysis of the SMN1 deletion in the Northern- Cyprus population
Authors: Abbasigharaei Sara , Bostancı Aysegul , Ergoren Mahmut Cerkez 
Published: December 2022

Abstract
SMA is a rare autosomal recessive neuromuscular, where one out of each 10,000 live births can be affected by this syndrome. The atrophy is caused by the gradual loss of alpha motor neurons, within the ventral spinal cord or motor nuclei within the lower brainstem. In this study, we aimed to evaluate the carrier frequency of SMN1 gene mutation causing SMA in Turkish Cypriot population. This is the first study to evaluate the SMN1 deletion mutations in this population. The mutation detection of SMN1 gene mutations, Exon 7 and 8 deletions, and c.849C/T substitution within exon 7 was carried out according to the manufacturer. In the total of 100 individuals, 3 patients turned out to be a carrier of the SMN1 gene in both exon 7 and 8 (carrier number 1) and another patient (Carrier number 2) showed a carrier status of SMN1 gene only in exon 7. Our findings revealed that the carrier frequency of mutation in the SMN1 gene for exon 7 is 4% (4:100 healthy individuals) while its mutation prevalence for exon 8 is 3% (3:100 healthy individuals). In conclusion, health precautions must be taken due to the high frequency of SMA linked to the deletion of the SMN1 gene. Carrier testing as a technique for genetic counseling may be advantageous for individuals with a positive family history. To this population, we strongly recommend prenatal testing. The Ministry of Health has received our findings, and they will decide whether to include tests for the SMN1 gene variant in premarital examinations.
Phosphorus-enriched organomineral fertilizers affect the cation exchange algorithm of the soil in the transition to organic farming in a calcareous soil: A comparative evaluation
Authors: Toprak Serdar , Seferoğlu Saime 
Published: December 2022

Abstract

The aim of this study is to determine the effects of phosphorus-enriched cattle manure applications on the exchangeable cations content, cation exchange capacity (CEC), and base saturation rate (BSR) of the lime soil. The research was carried out with five different levels of dairy cattle manure (DM0: 0; DM1: 10; DM2: 20; DM3: 30; DM4: 40 t ha− 1) and with five different levels of phosphorus dose (P0: 0; P1: 10; P2: 20; P3: 30; P4: 40 kg P ha− 1) in the ecological conditions of Southwest Türkiye during the wheat vegetation period of 2019–2021. The study was carried out in medium calcareous soil (14.8%) with three replications randomized blocks experimental by composing organomineral fertilizer combinations. In addition, nitrogen (urea) and potassium (potassium nitrate) fertilizers were also applied as support fertilizers during the wheat vegetation season for two years in the study. According to the results of the study, the highest change in exchangeable Ca and K content in soils was obtained from organomineral fertilizer applications by 11.2% and 29.7% respectively, and the highest change in exchangeable Mg and Na content was obtained from dairy cattle manure applications by 25.1% and 18.2%, respectively. Among the fertilization systems, the highest increase in total exchangeable cations was 13.1% and the increase in CEC was 21.3% in organomineral fertilizer applications. The fastest decrease in the BSR was also obtained from the organomineral fertilization system. As a result, it has been determined that M4P2 application is the most economical and the most effective combination in the cation exchange algorithm among organomineral fertilizer combinations.
Performance Analysis of P2P Network Content Delivery Based on Queueing Model
Authors: Ma Zhanyou , Yan Miao , Wang Rong , Wang Shunzhi 
Published: December 2022

Abstract

In P2P networks, content delivery is very critical, but there are not many relevant research results. In this paper, in order to simulate content delivery in P2P mode, online players are abstracted as servers that can provide services, the peers write content to buffer is abstracted as the customers' arrival, and the players read content from buffer is abstracted as the service process of the servers. An M/M/c queueing model with random variation in the number of servers is developed considering the influence of the number of P2P online servers on energy consumption, and negative customer and preemptive priority policies are introduced. The matrix-geometric solution method was used to derive performance measures for two types of customer, such as average queue length and average delay in the steady state of the system. And use Matlab to give some numerical examples to analyze the trend of performance measures with parameters in P2P networks. The benefit function is established to obtain the parameter values that make the social benefit optimal by Nash equilibrium and social optimal strategy.
Composition optimization of Bioactive glass /Chitosan /Zeolite ternary bio- composite
Authors: Moghaddam Nakisa , Oroujzadeh Nasrin , Salehirad Alireza 
Published: December 2022

Abstract
To achieve the desired mechanical and biological properties, the weight percentage of each component in bioactive glass/chitosan/zeolite bio-composite fabricated via the liquid phase method was optimized. In the first step: the weight percentage of zeolite was kept constant and the amounts of the other two components were modified considering the mechanical properties. In the second step, to optimize the weight percentage of the zeolite, the best sample of the first step was re-fabricated with different zeolite percentages (5 to 20 wt.%). All the bio-composites were identified by FT-IR, XRD, FE-SEM, and EDS, then their mechanical properties were measured. To determine the biological activity, samples were immersed in SBF for 1, 3, and 7 days and the hydroxyapatite growth rate was measured by XRD. Results specified that the sample with 65 wt.% bioactive glass/20 wt.% chitosan/15 wt.% zeolite had the best mechanical properties and had excellent hydroxyapatite growth in three days.
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria
Authors: Lu Kuan-Jen , Chang Chiung-Wen , Wang Chun-Hsiung , Chen Frederic Y-H , Huang Irene , Huang Pin-Hsuan , Yang Cheng-Han , Wu Hsiang-Yi , Wu Wen-Jin , Hsu Kai-Cheng , Ho Meng-Chiao , Tsai Ming-Daw , Liao James 
Published: December 2022

Abstract
Regulation of CO2 fixation in cyanobacteria is important both for the organism and the global carbon balance. Here we show that phosphoketolase in Synechococcus elongatus PCC7942 (SeXPK) possesses a distinct ATP sensing mechanism, which upon ATP drops, allows SeXPK to divert precursors of the RuBisCO substrate away from the Calvin-Benson-Bassham (CBB) cycle. Deleting the SeXPK gene increased CO2 fixation particularly during light-dark transitions. In high-density cultures, the Dxpk strain showed a 60% increase in carbon fixation, and unexpectedly resulted in sucrose secretion without any pathway engineering. Using cryo-EM analysis, we discovered that these functions were enabled by a unique allosteric regulatory site involving two subunits jointly binding two ATP, which constantly suppresses the activity of SeXPK until the ATP level drops. This magnesium-independent ATP allosteric site is present in many species across all three domains of life, where it may also play important regulatory functions.
Sialoadhesin (CD169/Siglec-1) is an extended molecule that escapes inhibitory cis-interactions and synergizes with other macrophage receptors to promote phagocytosis
Authors: Crocker Paul Richard , Klaas Mariliis , Ferguson David J P , Dubock Stuart 
Published: December 2022

Abstract
Sialoadhesin (CD169/Siglec-1, Sn) is a macrophage receptor that interacts with sialic acids on both host cells and pathogens. It is a type 1 membrane protein with an unusually large number of 17 extracellular immunoglobulin (Ig)-like domains, made up of an N-terminal V-set domain that binds sialic acid and 16 adjacent C2 set domains. The potential importance of 17 Ig domains in Sn for mediating cellular interactions has not been investigated experimentally. In the present study, Chinese Hamster Ovary (CHO) cells were stably transfected with full-length or truncated forms of Sn. Using human red blood cells (RBC) as a model system, CHO cells expressing truncated forms of Sn with 4 or less Ig domains were unable to bind RBC in comparison to the full-length protein. Immunoelectron microscopy of the CHO cells indicated that full-length Sn extends ~ 33 nm from the plasma membrane compared with ~ 14 nm for a truncated form with 6 N-terminal Ig domains. Co-expresssion of Sn-expressing CHO cells with heavily glycosylated membrane proteins of differing predicted lengths resulted in selective modulation of Sn-dependent binding to RBC and supported the hypothesis that Sn has evolved 17 Ig domains to escape inhibitory cis-interactions. The functional significance of the extended length of Sn was demonstrated in experiments with macrophages showing that Sn synergizes with phagocytic receptors FcR and TIM-4 to strongly promote uptake of IgG-opsonized and eryptotic RBCs respectively.
Design optimization of corona ring and grading ring for a 400kV Tension insulator
Authors: Archana C , K Usha 
Published: December 2022

Abstract
The design of polymer insulator depends on the surface electric field gradient. Increased electric field distribution generates corona discharge and leads to breakdown. Corona discharge has become an important factor not only because of corona losses but also due to electromagnetic interferences. Hence proper design optimization is necessary while designing the corona ring and grading ring which is employed at the critical region of the insulator to reduce the corona discharge. In this paper, optimized ring designs are identified for a 400kV tension type insulator. Three phase tension insulator along with the tower model is selected and its electric field distribution is calculated using finite element analysis. A 3D model design is developed using FEM based software. Seven structure parameters of the corona and grading rings are varied and the electric field is calculated. The optimized ring design is then achieved using multi-objective genetic algorithm. The obtained corona ring and grading ring parameters are compared with the simulated values and the error is less than 3%. Hence the proposed methodology can be used for prediction of corona ring and grading ring design, as the electric field is below the critical value.
A combination prediction model based on ELM and prior information of shapelet for algal bloom
Authors: Liu Mingwei , Zhang Huiyan , Wang Xiaoyi , Xu Jiping , Wang Li , Sun Qian , Wang Zhaoyang 
Published: December 2022

Abstract
Prediction is crucial to prevent the outbreaks of algal bloom. However, due to the time-varying and nonlinear characteristics of algal bloom, which brings challenges for accurate prediction. Aiming at solving the problem, we consider both prior information and data-driven, and propose an error compensation combination prediction model based on the manifold regularized extreme learning machine fused shapelet (ECM-MRELM-FS). First, the prior information is extracted as the upward shapelet set to discover and predict the value of algal bloom at the typical evolution mode. Meanwhile, a data-driven model of manifold regularized extreme learning machine (MRELM) is used to predict the value of algal bloom at other atypical evolution modes. This switching combination builds a prediction model by MRELM fused the upward shapelet, which can effectively utilize the advantages of prior information and data-driven. Then, an optimized T-S fuzzy inference systems as error compensation model (ECM) based on improved fuzzy c-means clustering is proposed to promote the accuracy of the prediction further. The experiments are performed by two real water quality datasets from USA and China. The final results demonstrate that the proposed combination prediction model can effectively predict algal bloom and provide a feasible and scientific early warning support for the water quality management in lake and reservoir.
Evaluating Professionalism and Design of Dental Practice Websites
Authors: Diego Jonathan San , Al-Kateb Jumana , Sagoo Anika , Sharka Rayan , Piper Kim 
Published: December 2022

Abstract
Aims and objectives
To develop an alternative evaluation checklist which is informed by Nichols and Hassall (2011) and illustrate how this can be applied to evaluate a random sample of dental practice websites on the basis of its usability, technical design and meeting professional standards and guidance mandated by a dental professional body.
Materials and methods
104 dental practice websites were systematically selected from a major city in the UK and evaluated using the 11Ps (alternative evaluation checklist). A primary and secondary analysis (by a second rater) was conducted of all the websites ensuring results were accurate and that all questions in the checklist were answered.
Results
Of the dental practices considered, none met all the specifications in the 11 Ps Evaluation Checklist. Our results revealed the frequency of compliance to various professional standards were low such as presenting information to the practices’ complaint’s procedure.
Conclusions
Dental practices in the UK would benefit from further guidance on how to design their websites in alignment with professional guidance. Compliance to some obligatory professional standards were high, however, many professional guidelines were not adhered to. Our proposed 11 P’s evaluation checklist can be further adapted for an in-depth assessment with consideration to professional standards, usability, and technical design.
Existence results to a Leray-Lions type problem on the Heisenberg Lie groups
Authors: Razani Abdolrahman , Safari Farzaneh 
Published: December 2022

Abstract
Here, the existence and multiplicity of weak solutions to a generalized (p(·), q(·))-Laplace equation involving the Leray-Lions type operators with Hardy potential are studied under the Dirichlet boundary conditions on the Heisenberg groups.
WITHDRAWN: Spotting lights on genotoxicity and mutagenicity of cobalt chloride -Induced Multi-organ Dysfunction: Impact of HIF1-α/TGF-β/Smad-2/Bax/Bcl2 signaling pathways
Authors: Ali Hanaa , Osman Mai 
Published: December 2022

Abstract
Cobalt chloride (CoCl2) is a ferromagnetic ubiquitous trace element that is commonly used in the production of diamonds, catalysts, and alloys. However, it might be considered a human health danger. Additionally, too much dietary cobalt can impair a variety of essential organs, which opens the door to understanding the toxicity of cobalt chloride in the liver, kidney, and cardiac tissues. To determine if the combination of arginine (Argi) and/or carnosine (Carn) can modify the expression of growth factors such Smad-2, TGF-, HIF1-, AKT mRNA, and apoptotic biomarkers Bax/ Bcl2 ratio by reducing the potentially harmful effects of cobalt chloride. Furthermore, investigate the new method by which these substances prevent Cobalt Chloride intoxication by preventing apoptosis in the target tissues. Organ poisoning was demonstrated by administering Cobalt Chloride at a dose of (60 mg/kg, SC), which was followed by treatments with Carnosine (200 mg/kg) and/or Arginine (200 mg/kg) 24 and 1 hour earlier, respectively. Hemoglobin concentration was dramatically reduced by cobalt chloride, meanwhile, protein expressions of hypoxia-inducible factor (HIF-1α), AKT, Suppressor of Mothers against decapentaplegic (Smad-2), transforming growth factor (TGF-β), and Bax/ Bcl2 ratio were elevated. Although, the combination of the fore mentioned antioxidants exerted a synergistic anti-apoptotic effect in all target tissues by the downregulation of the expression of the above-mentioned apoptotic biomarkers. It was revealed that Carn and Argi may inhibit apoptosis in response to cobalt chloride-induced poisoning through various signaling pathways.