bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Scoping Review of The Percutaneous Coronary Intervention: Practice Transformation for the Operational Access
Authors: Sazzad Faizus , Rahman Arifur 
Published: November 2022

Background: The transfemoral approach is the commonest and most widely practiced access for Percutaneous coronary intervention (PCI). However, the less invasive operational access for PCI is growing substantially and gaining popularity over the conventional practice. Although, there is little known about the true benefits regarding access for the PCI in adult Bangladeshi patients requiring coronary revascularization. This systematic review was aimed to compile literature evidence for the alternative PCI access when compared with standard transfemoral practice in our country.
Method: A scoping review according to the Preferred Reporting Items for Systematic Reviews and Metaanalyses (PRISMA) guidelines was conducted. As there is a scarcity of published literature comparing transfemoral vs alternative PCI routes, this scoping review was not aimed to produce a critical appraisal rather an overview and map of synthesized evidence based on the available literature.
Results: 498 articles were accessed from PubMed, BanglaJOL, and Web of Science databases. A total of seven articles were included for final analysis, comprising 1212 patients undergoing PCI at the different tertiary hospitals across the country. Among the included patients 834 PCI were performed via transfemoral access, 330 via transradial access, and 48 procedures were done via transulnar access.
Conclusion: Alternative access for PCI is gaining popularity in adult Bangladeshi patients requiring coronary revascularization. It’s a rational approach for the selective population in coronary revascularization strategy.
University Heart Journal 2022; 18(2): 106-117
A Case of Type 2 MI with Normal Coronary Arteries: Case Report & Literature Review
Authors: Anwar AFM Azim , Mumu Sanjida Anjum , Islam Azharul , Khaled Md Fakhrul Islam , Ahmed Khurshed , Hoque Md Harisul 
Published: November 2022

Clinicians have long recognized that acute myocardial infarction (MI) can occur in the absence of atherothrombosis . The Universal Definition of MI Global Taskforce introduced a classification system in 2007 (and reaffirmed in 2012) that defined type 2 MI (following standard diagnostic criteria) as MI occurring due to an imbalance in myocardial oxygen supply and/or demand not caused by atherosclerotic plaque disruption. Nevertheless, ambiguity remains regarding how to diagnose type 2 MI and how to distinguish it from both type 1 MI and myocardial injury. Here we report a case of a 23 year old young woman attended to emergency department, with typical chest pain and shortness of breath for 6 hours, Diarrhoea for 2 days, and single time loss of consciousness for 5 minutes, 6 hours before attending to hospital. Cardiac enzymes were rising titres in subsequent samples, Serum Creatinine was also high. Echocardiography performed 36 hour later, showed no regional wall motion abnormality, coronary angiogram showed normal coronary arteries. So, a diagnosis of Myocardial Infarction (Type 2 MI) with Non Obstructive Coronary Artery (MINOCA) was made, and MINOCA was attributed to hypovolemic shock (resulting from Dirrrahoea), manifested as MI, Syncope and AKI.
University Heart Journal 2022; 18(2): 128-131
Peran Orang Tua dalam Mengembangkan Kreativitas Anak Usia Dini pada Masa Pandemi Covid-19
Authors: Malikatus Sholihah  
Published: November 2022

This research was conducted to find out how the role of parents in developing early childhood creativity during the COVID-19 pandemic. The research subjects were students of RA Hidayatul Islamiyah, parents, teachers, and principals. Research data were collected by several techniques, such as observation, interviews, and documentation. The triangulation technique is carried out by means of triangulation of techniques and sources, namely by re-checking the information from interviews with documentation and observations and matching from one informant to other informants. The results of research on the role of parents in developing children's creativity in cooking cakes in the midst of the covid-19 pandemic, show that there are parents who pay less attention to children's learning activities at home, but there are also parents who collaborate with teachers to direct children to study at home.
The conclusion of this research is the role of parents who have high enthusiasm in developing children's learning creativity will have a good impact on children, especially during the current covid-19 pandemic, children really need the role of parents to develop children's creativity through cooking cakes taught at home.
Problematika dan Inovasi Pembelajaran Pada Masa Pandemi Di TK Assalam
Authors: Oktaviana Sovia 
Published: November 2022

COVID-19 merupakan pandemi yang menyebar hampir keseluruh belahan dunia termasuk Indonesia. Dengan adanya pandemi ini menyebabkan pola pendidikan menjadi berubah sehingga sistem pembelajaranpun ikut berubah dari menggunakan sistem luring menjadi daring. Penelitian ini ditujukan untuk mengetahui problematika dan inovasi yang dapat dilakukan pada pembelajaran dimasa pandemi COVID-19. Dalam pengumpulan data penulis menggunakan teknik observasi yang dilaksanakan di TK Assalam. Adapun metode yang digunakan dalam penyusunan artikel jurnal ini peneliti menggunakan metode deskriptif dengan jenis penelitian kualitatif. Dari hasil penelitian ditemukan bahwa pendidik mempergunakan metode home visit sebagai penanggulangan bagi siswa yang orang tuanya terkendala mengenai pengaplikasian internet dan alat multimedia, pendidik melakukan kegiatan pembelajaran secara berkelompok yang disesuaikan dengan daerah anak sebagai upaya untuk mengoptimalkan pembelajaran, terbukanya akses komunikasi antara pendidik dan orang tua sebagai penangulangan ketidak mampuan orang tua berperan menjadi seorang pendidik dan Kegiatan pembelajaran tidak difokuskan pada RPPH dalam upaya menanggulangi keterbatasan sarana dan prasarana di rumah siswa.
Analisis Tingkat Kognitif Pada Soal LKS SMP Kelas 8 Berdasarkan Taksonomi Bloom Revisi
Authors: Fitriani Melia Sari , Susanta Agus , Agustinsa Ringki , Utari Tria 
Published: November 2022

This study aims to determine the cognitive level of the questions on the LKS SMP grade 8 based on the revised bloom taxonomy. This type of research is descriptive with a qualitative approach. The type of research used is descriptive with a qualitative approach. Sources of data in this study are the total number of questions on the flat-sided shape of the math worksheets for class 8 semester 2 on the material of flat-sided shapes. The results of this study show that of 42 questions C1 (Remember) of 9,524% with a cognitive process of "Naming and Demonstrating", category C2 (Understanding) of 9,524% with cognitive processes of "Counting", category C3 (applying) of 64.3% with process cognitive "Applying, Executing and Implementing", category C4 (Analyze) by 16.67% with a cognitive process of "Analyzing and Organizing", category C5 (Evaluating) by 0%, category C6 (Creating) by 0%. From the results of the study it can be concluded that the questions on this worksheets have not met the ideal percentage of the cognitive level based on the 2013 curriculum. Keywords : Cognitive Level, LKS, Revised Bloom's Taxonomy
Long-term performance of a hybrid indirect evaporative cooling-mechanical vapor compression cycle: A case study in Saudi Arabia
Authors: Chen Qian , M Kum Ja , Burhan Muhammad , Shahzad Muhammad Wakil , Ybyraiymkul Doskhan , Oh Seungjin , Cui Xin , Ng Kim Choon 
Published: November 2022

In Saudi Arabia, air conditioning is the main consumer of electricity, and increasing its energy efficiency is of great importance for energy conservation and carbon footprint reduction. This study presents the evaluation of a hybrid indirect evaporative cooling-mechanical vapor compression (IEC-MVC) cycle for cooling applications in Saudi Arabia. Most cities in this country are characterized by a high sensible cooling demand, and a few cities near the coasts of the Red sea and the Persian Gulf also need dehumidification. By employing the hybrid system, IEC can undertake about 60% of the cooling load in the summer of arid cities, and energy consumption can be reduced by up to 50%. The contribution of IEC and energy saving are less significant in humid cities because the latent loads have to be handled by MVC. Over the whole year, IEC contributes 50% of the total cooling capacity and reduces energy consumption by 40% in dry cities, while the saving is lower at 15%–25% in humid cities like Mecca and Jeddah. The average water consumption of the IEC is in the range of 4–12 L/hr. The water consumption can be replenished by the condensate collected from the MVC evaporator if the ambient humidity is high. Based on the annual performance, the cost of the IEC-MVC process is calculated, and it is 15%–35% lower than the standalone MVC. The results demonstrate the great potential of the hybrid IEC-MVC cycle in Saudi Arabia.
Polymorphisms of the apolipoprotein E gene affect response to atorvastatin therapy in acute ischemic stroke
Authors: Bi QianQian , Zhou XiaoYu , Lu YanQin , Fu Wang , Wang YongPeng , Wang Feng , Wang Jue 
Published: November 2022

BackgroundPolymorphisms of the apolipoprotein E (APOE) gene are related to the efficacy of statin therapy. The biological functions of the APOE subtypes determine the metabolism of blood plasma lipids and the progression of atherosclerosis. This study aimed to explore the impact of APOE gene polymorphisms on the effect of atorvastatin on lipid regulation and plaque stabilization.MethodsThe study was a prospective cohort study that consecutively included patients with acute ischemic stroke (AIS) in the Department of Neurology, Shanghai Tenth People’s Hospital, from December 2018 to December 2019. The patients were divided into E2, E3, and E4 groups according to their APOE genotype. Atorvastatin (20 mg) was administrated to all patients. Changes in blood lipid levels over 3 months and plaque size and stability over 12 months were analyzed.ResultsWe enrolled 253 consecutive patients with AIS, of whom, 136 had carotid atherosclerotic plaques. Two patients with genotype E2/E4 were excluded. There were 30 patients in the E2 group (12.0%), 191 patients in the E3 group (76.0%), and 30 patients in the E4 group (12.0%). The lowest percentage reduction in low-density lipoprotein cholesterol (LDL-C) was observed in the E4 group (41.2%), while the highest percentage reduction was observed in the E2 group (17.6%). The plaques in the E2 group showed slower progression, while those in the E4 group showed more rapid progression.ConclusionAPOE gene polymorphisms affect the biological functions of atorvastatin. Compared to the ε3 or ε4 allele, the ε2 allele exerted a greater lipid-lowering effect on LDL-C levels, enhanced the ability of atorvastatin to stabilize carotid artery plaques, and slowed carotid artery plaque progression.
Pleural and mediastinal effusions after the extracardiac total cavopulmonary connection: Risk factors and impact on outcome
Authors: Heinisch Paul Philipp , Metz Paul , Staehler Helena , Mayr Benedikt , Vodiskar Janez , Strbad Martina , Ruf Bettina , Ewert Peter , Hager Alfred , Hörer Jürgen , Ono Masamichi 
Published: November 2022

BackgroundThis study investigated the volume and duration of pleural and mediastinal effusions following extracardiac total cavopulmonary connection, as well as preoperative risk factors and their impact on outcome.Materials and methodsA total of 210 patients who underwent extracardiac total cavopulmonary connection at our center between 2012 and 2020 were included in this study. Postoperative daily amount of pleural and mediastinal drainage were collected and factors influencing duration and amount of effusions were analyzed. The impact of effusions on adverse events was analyzed.ResultsMedian age at extracardiac total cavopulmonary connection was 2.2 (interquartile range, 1.8–2.7) years with median weight of 11.6 (10.7–13.0) kg. Overall duration of drainage after extracardiac total cavopulmonary connection was 9 (6–17) days. The total volume of mediastinal, right pleural, and left pleural drainage was 18.8 (11.9–36.7), 64.4 (27.4–125.9), and 13.6 (0.0–53.5) mL/kg, respectively. Hypoplastic left heart syndrome (p = 0.004) and end-diastolic pressure (p = 0.044) were associated with high volume of drainages, and hypoplastic left heart syndrome (p = 0.007), presence of aortopulmonary collaterals (p = 0.002), and high end-diastolic pressure (p = 0.023) were associated with long duration of drainages. Dextrocardia was associated with higher volume (p &lt; 0.001) and longer duration (p = 0.006) of left pleural drainage. Duration of drainage was associated with adverse events following extracardiac total cavopulmonary connection (p = 0.015).ConclusionVolume and duration of pleural and mediastinal effusions following extracardiac total cavopulmonary connection were related with hypoplastic left heart syndrome, aortopulmonary collaterals, and end-diastolic pressure. The duration of drainage for effusions was a risk factor for adverse events after total cavopulmonary connection.
Case report: Genomic screening for inherited cardiac conditions in Ecuadorian mestizo relatives: Improving familial diagnose
Authors: Cadena-Ullauri Santiago , Guevara-Ramirez Patricia , Ruiz-Pozo Viviana , Tamayo-Trujillo Rafael , Paz-Cruz Elius , Sánchez Insuasty Tatiana , Doménech Nieves , Ibarra-Rodríguez Adriana Alexandra , Zambrano Ana Karina 
Published: November 2022

IntroductionGenomic screening is an informative and helpful tool for the clinical management of inherited conditions such as cardiac diseases. Cardiac-inherited diseases are a group of disorders affecting the heart, its system, function, and vasculature. Among the cardiac inherited abnormalities, one of the most common is Wolff-Parkinson-White syndrome. Similarly, hypertrophic cardiomyopathy is another common autosomal dominant inherited cardiac disease. Hypertrophic cardiomyopathy is associated with an increased incidence of Wolff-Parkinson-White syndrome; reports have suggested that it could be caused by a mutation in the protein-coding gene PRKAG2, which encodes a subunit of the AMP-activated protein kinase.Case presentationA 37-year-old Ecuadorian male (Subject A) with familiar history of bradycardia, cardiac pacemaker implantation, and undiagnosed cardiac conditions began with episodes of tachycardia, dizziness, shortness of breath, and a feeling of fainting. He was diagnosed with hypertrophic myocardiopathy and Wolff Parkinson White preexcitation syndrome. Furthermore, his cousin's son, an 18-year-old Ecuadorian male (Subject B), started suffering from migraine and tachycardia at any time of the day. He was diagnosed with hypertrophic myocardiopathy; his electrocardiogram showed a systolic overload. Next-generation sequencing and ancestry analyses were performed. A c.905G&gt;A p.(Arg302Gln) mutation in the gene PRKAG2 and a mainly European composition were identified in both subjects.ConclusionGenetic testing is a valuable tool as it can provide important information regarding a disease, including its cause and consequences, not only for single individuals but to identify at-risk relatives. Furthermore, NGS results could guide the physician into targeted therapy. In the present case report, a missense pathogenic Arg302Gln mutation in the PRKAG2 gene has been identified in two related Ecuadorian Subjects diagnosed with hypertrophic myocardiopathy and Wolff-Parkinson-White. The variant has not been reported in Latin America; hence, this is the first report of the Arg302Gln mutation in the PRKAG2 gene in mestizo Ecuadorian subjects with mainly European ancestry components.
99mTc-sestamibi and 18F-fluorodeoxyglucose imaging in patients with cardiogenic shock: A pilot study
Authors: Hua Cuncun , Cai Qizhe , Xi Xiao-Ying , Lin Mingming , Wang Li , Li Lina , Yao Dandan , Liu Xiaoyan , Zhao Lei , Wang Lefeng , Su Pixiong , Xie Boqia 
Published: November 2022

BackgroundWhether perfusion/metabolism imaging differs between matched ST-segment elevation myocardial infarction (STEMI) patients with and without cardiogenic shock (CS) remains unknown.MethodsSeventeen STEMI patients with CS (13 men, 60 ± 12 years) and 16 matched STEMI patients without CS (15 men, 54 ± 15 years) were prospectively recruited. All patients underwent baseline 99mTc-sestamibi/18F-fluorodeoxyglucose (FDG) imaging and echocardiography 6 ± 2 days post-infarction. Nine patients with CS and seven without CS had repeated imaging 98 ± 7 days post-infarction. The total perfusion deficit (TPD) and total FDG uptake deficit (TFD) were calculated to assess the percentages of impaired perfusion and metabolism over the left ventricle. Patients were followed up for 337 days (213–505 days) and the major adverse cardiac events (MACE) were recorded.ResultsTPD was greater in patient with CS and was independently related to the presence of CS (OR: 4.36, p = 0.013). Both acute- and convalescent TFD were inversely related to the improvement ratio of LVEF (r-values: −0.62, −0.73; both p &lt; 0.05). MACE occurred in 16 patients (10 CS and 6 non-CS), and acute TFD was predictive of MACE in those with CS (HR: 2.06, p = 0.038).ConclusionIn this pilot study, we demonstrated that STEMI patients with CS had a significantly increased TPD, which was relevant to the presence of CS. Acute TFD was associated with improvement in LVEF, and was predictive of MACE in patients with CS.
Underlying microangiopathy and functional outcome of simultaneous multiple intracerebral hemorrhage
Authors: Li Jiawen , Shen Dan , Zhou Yanli , Jin Yujia , Jin Luhang , Ye Xianghua , Tong Lusha , Gao Feng 
Published: November 2022

ObjectiveTo identify the predominant type of cerebral small vessel disease (SVD) and outcomes in patients with simultaneous multiple intracerebral hemorrhages (SMICH).MethodsConsecutive patients with intracerebral hemorrhage (ICH) from a single-center prospective cohort were retrospectively reviewed. Presumed etiology was classified according to the SMASH-U criteria. Demographics, clinical and laboratory variables, and neuroimaging data were compared between patients with primary SMICH and those with single ICH. Functional outcomes were assessed using the modified Rankin scale 90 days after ICH.ResultsOf the 598 enrolled patients, 37 (6.2%) met the criteria for SMICH. Risk factors for SMICH included a high burden of deep cerebral microbleeds (CMBs) (odds ratio [OR] 1.06, 95% confidence interval [CI], 1.00–1.12; p = 0.040), white matter hyperintensity scores (OR 1.27, 95% CI 1.04–1.57; p = 0.021), history of ICH (OR 3.38, 95% CI 1.31–8.05; p = 0.008), and low serum magnesium levels (OR 0.01, 95% CI 0.00–0.25; p = 0.007). Based on the SMASH-U classification, 15(40.5%) SMICH were classified as hypertension, whereas 17 (45.9%) as undetermined-etiology. To further explore the potential microangiopathy underlying undetermined-SMICH, these patients with undetermined-etiology were compared to those with cerebral amyloid angiopathy-ICH, and were associated with a higher burden of deep CMBs but less severe centrum semiovale enlarged perivascular spaces. Likewise, compared with hypertension-ICH patients, those with undetermined SMICH were consistently associated with a higher deep CMB counts. Moreover, multivariate analysis revealed that SMICH was independently associated with poor outcomes (OR 2.23, 95%CI 1.03–4.76; p = 0.038).ConclusionOur results suggest that most patients with primary SMICH harbor hypertensive-SVD as principal angiopathy. Patients with SMICH are at a high risk of poor outcomes. (ClinicalTrials.gov Identifier: NCT 04803292).
Differential effects of intermittent energy restriction vs. continuous energy restriction combined high-intensity interval training on overweight/obese adults: A randomized controlled trial
Authors: Xu Rui , Cao You-Xiang , Chen Yu-Ting , Jia Yu-Qi 
Published: November 2022

BackgroundIntermittent energy restriction (IER) and continuous energy restriction (CER) are increasingly popular dietary approaches used for weight loss and overall health. These energy restriction protocols combined with exercise on weight loss and other health outcomes could achieve additional effects in a short-term intervention.ObjectivesTo evaluate the effects of a 4-week IER or CER program on weight, blood lipids, and CRF in overweight/obese adults when combined with high-intensity interval training (HIIT).MethodsForty-eight overweight/obese adults [age: 21.3 ± 2.24 years, body mass index (BMI): 25.86 ± 2.64 kg⋅m–2] were randomly assigned to iER, cER, and normal diet (ND) groups (n= 16 per group), each consisting of a 4-week intervention. All of the groups completed HIIT intervention (3 min at 80% of V̇O2maxfollowed by 3 min at 50% of V̇O2max), 30 min/training sessions, five sessions per week. iER subjects consumed 30% of energy needs on 2 non-consecutive days/week, and 100% of energy needs on another 5 days; cER subjects consumed 70% of energy needs; and ND subjects consumed 100% of energy needs. Body composition, waist circumference (WC) and hip circumference (HC), triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), high-density lipoprotein-cholesterol (HDL-c), and cardiorespiratory fitness (CRF) were measured before and after the intervention.ResultsOf the total 57 participants who underwent randomization, 48 (84.2%) completed the 4-week intervention. After intervention body composition and body circumference decreased in three groups, but no significant differences between groups. The iER tends to be superior to cER in the reduction of body composition and body circumference. The mean body weight loss was 4.57 kg (95% confidence interval [CI], 4.1–5.0,p&lt; 0.001) in iER and 2.46 kg (95% CI, 4.1–5.0,p&lt; 0.001) in iER. The analyses of BMI, BF%, WC, and HC were consistent with the primary outcome results. In addition, TG, TC, HDL-c, and CRF improved after intervention but without significant changes (p&gt; 0.05).ConclusionBoth IER and CER could be effective in weight loss and increased CRF when combined with HIIT. However, iER showed greater benefits for body weight, BF%, WC, and HC compared with cER.
Low-dose sclerotherapy with lauromacrogol in the treatment of infantile hemangiomas: A retrospective analysis of 368 cases
Authors: Wang Changfeng , Sun Jiali , Guo Lei , Song Dan , Zhang Xin , Liu Zhuang , Wang Liang 
Published: November 2022

BackgroundIntralesional injection of lauromacrogol has proven to be an efficient treatment method for infantile hemangioma. This study aims to explore a novel injection therapy and evaluate its efficacy and complications.MethodsThe medical records of 368 children with infantile hemangioma who received a lauromacrogol injection from January 2021 to April 2022 were retrospectively analyzed. All patients were reviewed every 4 weeks, and their condition was assessed according to symptoms and medical records. The patient’s age, lesion type, location, size and thickness, lesion photographs, ultrasound, and complications were recorded.ResultsAmong the 368 infants who accept sclerotherapy with lauromacrogol, 226(61.4%)achieved excellent regression. In total, 108(29.4%)cases achieved good regression. 24(6.5%)achieved complete moderate regression. 10(2.7%)achieved poor regression. The reported incidence of adverse events was 4.9% and severe complications were not observed. Before and after three courses of treatment, the median vascular endothelial growth factor levels were 104.12 pg/ml and 28.982 pg/ml. There was a significant difference between the two groups (P=0.0043).ConclusionsThe results showed that this novel injection therapy a safe and effective treatment method. The therapy accelerated the regression of infantile hemangiomas without serious complications.