bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole-genome sequence analysis of high-level penicillin-resistant strains and antimicrobial susceptibility of Neisseria gonorrhoeae clinical isolates from Thailand
Authors: Nokchan Natakorn , Wongsurawat Thidathip , Jenjaroenpun Piroon , Nitayanon Perapon , Tribuddharat Chanwit 
Published: July 2022

BackgroundThe increasing rate of antimicrobial-resistantNeisseria gonorrhoeaeposes a considerable public health threat due to the difficulty in treating gonococcal infections. This study examined antimicrobial resistance (AMR) to drugs recommended for gonorrhea treatment between 2015 and 2017, and the AMR determinants and genetic compositions of plasmids in 3 gonococcal strains with high-level penicillin resistance.MethodsWe collected 117N.gonorrhoeaeisolates from patients with gonococcal infections who attended Siriraj Hospital, Bangkok, Thailand, between 2015 and 2017. Minimum inhibitory concentrations (MICs) of penicillin, tetracycline, ciprofloxacin, azithromycin, spectinomycin, cefixime, and ceftriaxone were determined by the agar dilution method. PCR amplification and sequencing of 23S rRNA andmtrR(a negative regulator of MtrCDE efflux pump) were performed. Whole genomes of 3 PPNG strains with high-level penicillin resistance (MIC ≥ 128 μg/ml) were sequenced using Illumina and Nanopore sequencing platforms.ResultsThe proportions ofN.gonorrhoeaeisolates with resistance were 84.6% for penicillin, 91.5% for tetracycline, and 96.6% for ciprofloxacin. All isolates were susceptible to spectinomycin, azithromycin, cefixime, and ceftriaxone. An adenine deletion within a 13 bp inverted repeat sequence in themtrRpromoter and an H105Y mutation in themtrRcoding region were found in theN.gonorrhoeaeisolate with the highest azithromycin MIC value (1 μg/ml). Three high-level penicillin-resistant isolates contained nonmosaic type IIpenAand had mutations inpenBand themtrRcoding region. All isolates with high-level penicillin resistance carried the conjugative plasmids with or without the Dutch typetetMdeterminant, the beta-lactamase plasmid (Rio/Toronto), and the cryptic plasmid.ConclusionsThe gonococcal population in Thailand showed high susceptibility to ceftriaxone and azithromycin, current dual therapy recommended for gonorrhea treatment. As elevated MIC of azithromycin has been observed in 1 strain ofN.gonorrhoeae, expanded and enhanced surveillance of antimicrobial susceptibility and study of genetic resistance determinants are essential to improve treatment guidelines.
Beyond arboviruses: A multicenter study to evaluate differential diagnosis of rash diseases and acute febrile illness cases in Rio de Janeiro, Brazil
Authors: Alves Arthur Daniel Rocha , Raposo Jéssica Vasques , de Sousa Rafaela Moraes Pereira , Cardoso Claudete Aparecida Araújo , Costa Pâmela Karla Simões de Freitas , Araújo Julienne Martins , Barreiro Sabrina Teresinha Alvim , Bressan Clarisse da Silveira , Calvet Guilherme Amaral , de Souza Rogério Valls , Brasil Patrícia , Cubel Garcia Rita de Cássia Nasser , Pinto Marcelo Alves , de Paula Vanessa Salete , Amado Luciane Almeida 
Published: July 2022

Introduction
A wide variety of viruses can cause rash diseases (RDs) or acute febrile illness (AFIs) in children, adolescents and adults; however, approximately 19% of RD cases and 40% of AFI cases remain without a defined etiology. Parvovirus B19 (B19V) and herpesvirus infection can also cause RD and/or AFI, and in some risk groups, these infections can become persistent (or latent) and may require hospital treatment. Since these infections do not have mandatory reporting, they can be hidden by other diseases, such as those caused by arboviruses (e.g., dengue virus). In this context, the aim of this study was to pursue the differential laboratory diagnoses of B19V and herpesvirus infections in patients with RD and AFI, without a defined etiology, seen in hospitals and/or reference centers for infectious diseases in Rio de Janeiro.

Methods
A total of 114 participants were enrolled in the study, including 54 children and 60 adults. B19V infection was assessed by real-time PCR (qPCR) and ELISA (anti-B19V IgM and IgG). EBV was assessed through qPCR, and betaherpesviruses (HCMV, HHV-6 and HHV-7) were assessed through multiplex qPCR. Sociodemographic and clinical data were obtained from the medical record data of these participants.

Results
The median age of children with RD was 2 years (interquartile range (IQR): 5), and 55.6% were male. Among adults with AFI, the median age was 38 years (IQR: 21), and 56.7% were female. Regarding RD patients, viral prevalence (and load) were 5.5%(104IU/mL), 3.4%(104IU/mL), 5.5%(104IU/mL) and 11.1%(105IU/mL) for B19V, EBV, HCMV and HHV-6 infection, respectively, and in AFI patients they were 6.6%(105IU/mL), 1.6%(103IU/mL), 3.3%(104IU/mL) for B19V, HCMV and HHV-6, respectively. HHV-7 was not detected in RD or AFI patients.

Conclusion
These results suggest the importance of including B19V and herpesviruses in the differential laboratory diagnoses for patients with RD and AFI, not only for epidemiological purposes but also for the proper management of the patient.
Antimicrobial agents for the treatment of enteric fever chronic carriage: A systematic review
Authors: McCann Naina , Scott Peter , Parry Christopher M. , Brown Michael 
Published: July 2022

Background
Chronic carriage of S. Typhi or S. Paratyphi is an important source of enteric fever transmission. Existing guidance and treatment options for this condition are limited. This systematic review aims to assess the evidence concerning the efficacy of different antimicrobials in treating enteric fever chronic carriage.

Methods
We searched major bibliographic databases using relevant keywords between 1946 and September 2021. We included all interventional studies that included patients with confirmed enteric fever chronic carriage and deployed an antimicrobial that remains in clinical practice today. Case reports and case series of under 10 patients were excluded. Two reviewers screened abstracts, selected articles for final inclusion and quality-assessed the included studies for risk of bias. Extracted data was analysed, with pooling of data and eradication rates for each antimicrobial calculated. As only one randomised controlled trial was identified, no meta-analysis was performed.

Results
Of the 593 papers identified by the initial search, a total of eight studies met the inclusion criteria and were included in the systematic review. Evidence was identified for the use of fluoroquinolones and amoxicillin/ampicillin in the treatment for enteric fever chronic carriage. Fluoroquinolones were superior to amoxicillin/ampicillin with 92% of patients achieving eradication after one antimicrobial course compared to 68% (p = 0.02). The quality of included studies was poor, and all were carried out before 1990.

Conclusion
This review identified fluoroquinolones and amoxicillin/ampicillin as treatment options for enteric fever chronic carriage, with fluoroquinolones the more effective option. However, this evidence pre-dates rises in antimicrobial resistance in enteric fever and therefore the significance of these findings to today’s practice is unclear. Further research is needed to investigate whether these antimicrobials remain appropriate treatment options or whether alternative interventions are more effective.
BILINGUAL CURRICULUM MATERIALS SUPPORTING SIGNED LANGUAGE AS A FIRST LANGUAGE FOR DEAF STUDENTS
Authors: Hoffmeister Robert J , Karipi Spyridoula , Kourbetis Vassilis 
Published: July 2022

Considering Deaf children and adults as bilingual - their first language is a Signed Language (SL) and the second language is learned via print - provides professionals with a paradigm to be used for creating better learning opportunities. In this paper, Greek Sign Language ((G)SL)) [1] as a first language (L1) is the base language we use to present certain bilingual methodological teaching and learning considerations. This work is the result of a long journey from the initial thinking of the American Sign Language Curriculum and its influence on the development of the (G)SL curriculum in Greece. The paper offers discussion of innovative educational multimedia material that are easily accessed via online web portals, developed for teaching (G)SL as an L1 to pre-school and primary school Deaf children. In this work, SL as L1 is a resource that fully enables Deaf children to learn an L2 via print, supporting their bilingual acquisition capabilities. In developing curricula and supporting materials, we consider two important foundational components: Deaf native signers and near native signers as language role models for Deaf children, parents and teachers; and the development and interaction with digital educational materials. Thus, collaboration between educational and technology professionals and members of the Deaf community is critical. This bilingual model can be incorporated into any SL. (G)SL) is used as a model to display innovative practices merging SL (L1), print (L2), technology and creative instructional and assessment materials, maximized by understanding the visual nature of SL and its advantages for school learning. The penultimate goal is Deaf students to become successful bilingual learners to fully function in the world today and tomorrow.

[1] In this paper, we will use (G)SL to indicate that we are discussing Greek Signed Language but content and technology can be used for any SL.
Yo llana estoy: Jerarquías, transgresiones y despliegues de género en América hispana colonial (1492–1898)
Authors: Silva Yamile , Burgos Ana María Díaz 
Published: July 2022

Resumen
Esta introducción al dossier temático sobre género y sexualidades en la América hispana colonial revisita los debates académicos recientes sobre estos temas a la vez que los pone en diálogo con los cinco ensayos que lo conforman. Estos ensayos examinan las transgresiones de género y sexualidades en territorios hispanoamericanos entre el siglo XVI y principios del siglo XIX teniendo en cuenta dos ángulos de análisis: los usos de la ley y los del cuerpo. Complementan este dossier dos entrevistas a autoras latinoamericanas que demuestran la extensión de estos temas coloniales a los campos de la producción literaria contemporánea.
Bailadoras: Las mujeres y el fandango en España y la Nueva España del siglo XVIII
Authors: Deanda-Camacho Elena 
Published: July 2022

Resumen
Este ensayo analiza las descripciones que viajeros y clérigos hicieron de las bailadoras de fandango en España y la Nueva España en el siglo XVIII. El fandango fue tanto un baile español como un tipo de fiesta popular novohispana. En esta época, ambos manifestaron “dramas sociales”–siguiendo a Víctor Turner—en los cuales grupos hegemónicos y clases bajas se enfrentaron. Viajeros y clérigos condensaron esos “dramas” en la descripción del cuerpo de la bailadora, quien apareció erotizada o exotizada. En los intersticios de sus descripciones, elucido vestigios de la práctica estética de la bailadora y cómo simultáneamente ella creó comunidad a la par que afirmaba su individualidad.
Anarquismo y naturalismo en la obra temprana de Salvadora Medina Onrubia
Authors: Carballo Alejandra Karina 
Published: July 2022

Resumen
La obra temprana de Salvadora Medina Onrubia testimonia demandas sociales emergentes a principios del siglo XX que el anarquismo hacía en nombre de los desclasados y oprimidos. Basado en un discurso anarco-positivista, Medina Onrubia denuncia arbitrarias e inhumanas condiciones de trabajo y de vivienda, además de la inequidad salarial y legal que afectaban tanto a la familia rural como a la proletaria bajo los mismos opresores: el Estado y la élite gobernante. Temas tales como el de la tuberculosis y el alcoholismo, así como el trabajo y la independencia femeninos son tratados en su obra en términos biologizantes y de género.
Programa de Educação Tutorial e OBMEP na escola: influências na formação inicial de futuros professores de matemática
Authors: Peixoto Rafael , Cintra Vanessa de Paula , Paulin Juliana França Viol 
Published: July 2022

Neste artigo analisamos aspectos relevantes sobre a formação inicial de alunos do curso de Matemática de uma Universidade Pública que participaram do Programa de Educação Tutorial (PET), no projeto de extensão intitulado “PET Matemática na OBMEP na escola”, que envolve ações desenvolvidas pelos participantes junto à Olimpíada Brasileira de Matemática das Escolas Públicas (OBMEP). Trata-se de uma pesquisa qualitativa e os dados foram coletados por meio de questionários respondidos pelos participantes do projeto e analisados segundo a Análise de Conteúdo. Com a análise dos dados, pudemos identificar que as vivências dos futuros professores de Matemática na escola, possibilitadas pelo projeto conjunto entre o PET e a OBMEP, podem ser caracterizadas como uma oportunidade de construção do conhecimento matemático para o ensino e do conhecimento da prática, gerada pelo terceiro espaço de formação.
Erosividade da Chuva no Município de São Pedro - SP: Análise entre 1960-2020
Authors: Neves Monique , Di Lollo José Augusto 
Published: July 2022

No município de São Pedro - SP, a erosão hídrica afeta tanto a área urbana como a rural e acarreta perdas ambientais, sociais e econômicas. Para compreender a dinâmica dos processos erosivos é fundamental conhecer as características do meio físico, entre elas o potencial erosivo das chuvas. Nesse contexto, o objetivo deste trabalho foi caracterizar o potencial erosivo das chuvas no município de São Pedro, localizado na região centro-leste do estado de São Paulo, utilizando dados de chuva mensal para quatro cenários temporais: 1962, 1972, 1988, 2010 e 2020. A análise foi desenvolvida com base na precipitação média anual, Índice de Erosividade (EI30) e Coeficiente de Chuvas (R). Para representar espacialmente a erosividade foi utilizado o método de interpolação Inverso da Potência da Distância (IPD) em ambiente SIG (ArcGIS). Índices mais elevados foram observados nos anos de 1962 e 1972 e indicam que houve uma redução do potencial erosivo. Os resultados permitiram concluir que no município ocorreram chuvas com médio e alto potencial erosivo e, portanto, considerando sua ação conjunta com outros fatores ambientais e antrópicos, pode favorecer a deflagração e evolução das erosões. Além disso, esses resultados são importantes e podem auxiliar ações de manejo e conservação do solo, bem como a gestão do território, em conformidade com as características do meio físico.
Analysis of multitemporal compositing techniques from regular and non-regular intervals using MODIS daily images in the Amazon region with a high percentage of cloud cover
Authors: Salgado Cristiane Batista , Carvalho Junior Osmar Abílio , Santana Nickolas Castro , Gomes Roberto Arnaldo Trancoso , Guimarães Renato Fontes , Silva Cristiano Rosa 
Published: July 2022

One challenge in the study of optical remotely sensed time series in the Amazon is the constant cloud cover. The present study evaluates different compositing techniques using regular and non-regular intervals to obtain cloud-free images over large areas. The study area was the municipality of Capixaba in the State of Acre, belonging to the Amazon region. The tests considered four compositing algorithms (maximum, minimum, mean, and median) for daily MODIS sensor data (b1 and b2, 250m). The compositing technique from regular intervals adopted the following periods: 8, 16, 24, 32, 40, and 48 days. The irregular interval composite images adopted different composition intervals for dry seasons (April to September) and rainy (October to March). The cloud mask and viewing angle constraint allowed to obtain information without atmospheric interference and closest to nadir view. The composite images using regular intervals did not allow to overcome the high frequency of cloud cover of the region. The composite images from non-regular intervals presented a higher percentage of cloud-free pixels. The mean and median methods provided the better visual appearance of the images, corroborating with the homogeneity test. Therefore, composite images from non-regular intervals may be an appropriate alternative in places with constant cloud coverage.
Comparative Studies of Photochemical and Electrochemical Methods on Mineralization of Picric Acid
Authors: Ingale Sanjay Vishwasrao , Kumar Ratanesh , Wagh Pratap B , Joshi K D 
Published: July 2022

The effluents generated from synthesis and processing plant of Picric acid is reported to be carcinogenic and hence needs to be treated to reduce its concentration below safe discharge limit. Present paper deals with studies on mineralization of Picric acid by adopting photochemical and electrochemical processes and the efficacy of the both processes have been explored in details. Crucial process parameters viz. pH, concentration of oxidizer and catalyst for mineralization of Picric acid are optimized. In photochemical method, It is observed that Picric acid is treated to bring down its concentration from 100 ppm to ≤ 1 ppm under Photo-Fenton process in 2 hrs whereas same treatment carried out under Photo- catalytic process takes only 1 hr. It is also observed that TiO2 xerogel and beads of nano-TiO2 are more efficient compared to that of commercially available TiO2. The TiO2–Polysulfone (PS) beads show less efficiency than TiO2 xerogel. However, the Picric acid oxidation efficiency for TiO2–PS beads is comparable and advantage of TiO2–PS beads is that it can easily be recovered from the treated solution and can be reused in the next experiments. Electrochemical process is user’s friendly and economical. In case of electrochemical treatments at optimized process parameters under Electro-Fenton reaction picric acid is completely mineralized below its drain discharge limit where as under Electro-peroxide reaction picric acid is mineralized upto 3 ppm within 3 hrs. The treated solution has been characterized by using UV-Visible spectrophotometer, High performance Liquid Chromatography (HPLC) and Total Organic Carbon (TOC) Analyzer. The observed results have been interpreted and reported in the present paper.
FAKTOR-FAKTOR PRENATAL YANG MEMPENGARUHI STUNTING PADA ANAK USIA 0-2 TAHUN DI WILAYAH ASIA TENGGARA: LITERATURE REVIEW
Authors: Syabania Riri , Yuniar Pravita Ayu , Fahmi Ilmia 
Published: July 2022

ABSTRAKLatar Belakang: Stunting merupakan masalah kurang gizi kronis yang diukur dengan indikator TB/U. Anak usia 0-2 tahun termasuk stunting jika memiliki nilai z-score TB/U ≤ -3,0 SD. Pertumbuhan dan perkembangan anak stunting mengalami gangguan karena gizi buruk, infeksi, serta kondisi psikososial yang kurang memadai. Masa prenatal adalah faktor risiko stunting yang berada pada fase awal.Tujuan: Tujuan kajian literatur ini yaitu menganalisis faktor-faktor prenatal yang menyebabkan stuntingMetode: Metode penulisan artikel ini menggunakan literature review. Sumber data yang digunakan merupakan penelitian yang berasal dari wilayah Asia Tenggara dengan subjek anak usia 0-2 tahun. Penelusuran artikel menggunakan database Google Scholar, Pubmed, dan Science Direct. Didapatkan 8 artikel yang sesuai dengan kriteria inklusi.Hasil: Faktor prenatal yang menyebabkan stunting pada anak usia 0-2 tahun adalah tinggi badan ibu, Ibu dengan tinggi badan <145 cm memiliki HAZ yang lebih rendah dibandingkan dengan anak yang memiliki Ibu dengan tinggi badan >145 cm. Anemia selama kehamilan meningkatkan risiko 3,23 kali lebih besar anak terkena stunting, keberagaman makanan saat prenatal yang merupakan komponen penting dalam menentukan status gizi anak, maternal depression melipatgandakan resiko memiliki anak stunting, kunjungan ke fasilitas kesehatan selama kehamilan juga menjadi faktor penyebab stunting. Fasilitas sanitasi di rumah yang tidak memadai memiliki risiko 40% lebih tinggi terhadap kejadian stunting.Simpulan: Faktor prenatal yang mempengaruhi stunting terdiri dari tinggi badan Ibu, anemia selama kehamilan, keberagamanan makanan saat masa kehamilan, maternal depression, kunjungan health care, dan fasilias sanitasi
On the solutions to p-Poisson equation with Robin boundary conditions when p goes to +∞
Authors: Amato Vincenzo , Masiello Alba Lia , Nitsch Carlo , Trombetti Cristina 
Published: July 2022

Abstract
We study the behaviour, when

p
→
+
∞

p\to +\infty

, of the first p-Laplacian eigenvalues with Robin boundary conditions and the limit of the associated eigenfunctions. We prove that the limit of the eigenfunctions is a viscosity solution to an eigenvalue problem for the so-called

∞

\infty

-Laplacian. Moreover, in the second part of the article, we focus our attention on the p-Poisson equation when the datum

f

f

belongs to

L

∞

(

Ω

)

{L}^{\infty }\left(\Omega )

and we study the behaviour of solutions when

p
→
∞

p\to \infty

.
Immersive VR training system for clipping intracranial aneurysms
Authors: Allgaier Mareen , Neyazi Belal , Erol Sandalcioglu I. , Preim Bernhard , Saalfeld Sylvia 
Published: July 2022

Abstract
Training clipping of intracranial aneurysms is challenging due to less frequent interventions because of minimalinvasive methods, ethical aspects regarding cadaver training and consumption of resources when using 3D printed models. By proposing an immersive virtual reality training system, we make use of increased motivation, engagement and realism when using a virtual operating room. In this simulation, a selected microsurgical clip can be applied at the aneurysm neck. Before closing the clip and deforming the vessels, the affected area is visualized to assess the clip position. Our qualitative evaluation with two neurosurgeons with different levels of experience indicates benefits such as increased motivation, presence, and the possibility to try out different strategies. However, some surgical steps can be refined to increase realism and learning effect, and interactions can be further improved. The proposed training system benefits from training by trial and error in an engaging environment leading to an improved training experience.
Centerline and blockstructure for fast structured mesh generation
Authors: Niemann Annika , Janiga Gabor , Preim Bernhard , Behme Daniel , Saalfeld Sylvia 
Published: July 2022

Abstract
In contrast to unstructured meshes, structured meshes yield faster simulation results for bio-medical simulations, but are very time-consuming to create. A preprocessing step in the generation of structured meshes is the manual construction of a blockstructure approximating the vessel. Here, we present an automatic centerline calculation and blockstructure generation to reduce the user effort and time of structured mesh generation. The centerline is detected as points in between opposite faces. Based on the centerline, cross sections are determined and a blockstructure which approximates the vessel is automatically generated. The centerline detection does not require time-consuming user input and meshes with more than 195,000 vertices are processed in less than 160 seconds. The results of the presented automatic centerline detection are compared to a centerline with manual input generated by the widely used vmtk tool. The centerlines are similar, small differences occur at bifurcation and at the aneurysm.