bluuebunny/crossref_metadata_2025_split huggingface dataset:
ВЗАЄМОДІЯ РАХУНКОВОЇ ПАЛАТИ УКРАЇНИ З ІНШИМИ СУБ’ЄКТАМИ ДЕРЖАВНОГО ФІНАНСОВОГО КОНТРОЛЮ
Authors: Maletska O.I. 
Published: January 2022

Взаємодія Рахункової палати України з іншими суб’єктами державного фінансового контролю. Ураховуючи актуальність обраної тематики дослідження, метою статті є подальше теоретичне дослідження такого органу зовнішнього контролю, як Рахункова палата України, з’ясування особливостей взаємодії вищезазначеного органу контролю з іншими суб’єктами державного фінансового контролю: Верховна Рада України, Кабінет Міністрів України, Президент України. В процесі написання статті застосовано індуктивний, дедуктивний методи, які використано для дослідження функцій Рахункової палати. Графічний метод використано для наочного відображення побудови та формуванні повноважень Рахункової палати відповідно до норм законодавства. Для теоретичних узагальнень і формування висновків застосовано абстрактно-логічний метод.
Установлено, що державний фінансовий контроль, який здійснюється Рахунковою палатою України у формі аудитів, перевірок, є вагомою функцією управління фінансовою системою, що спрямована на упередження та запобігання фінансово-економічних порушень у сфері використання бюджетних коштів. У зв’язку з цим головною метою державного фінансового контролю є забезпечення дотримання принципів законності, доцільності та ефективності розпорядчих і виконавчих дій з управління державними фінансами та майном держави, їх збереження і примноження для повноцінного виконання функцій держави.
Зазначено, що об’єктом державного фінансового контролю є грошові відносини, що виникають у процесі формування і використання публічних фінансів і майна держави, а також інших суб’єктів господарювання. Ними виступають юридичні особи, які від імені держави (відповідно до врегульованих правових норм), здійснюють моніторинг й інші форми контролю за діяльністю суб’єктів господарювання в частині дотримання ними встановлених обмежувальних параметрів щодо обігу фінансових ресурсів.
У результаті проведеного дослідження теоретичних та практичних питань функціонування системи державного фінансового з Рахунковою Палатою України вважаємо, що необхідно уточнити засади взаємодії Палати з іншими органами фінансового контролю.
Теоретичну та практичну цінність дослідження полягає в виявленні рівня взаємодії Рахункової палати України з іншими суб’єктами державного фінансового контролю
Vitamin C Deficiency Causes Cell Type–Specific Epigenetic Reprogramming and Acute Tubular Necrosis in a Mouse Model
Authors: Yu Zihui , Xu Ziying , Liang Yuan , Yin Pengbin , Shi Yue , Yu Jiayi , Hao Junfeng , Wang Ting , Ci Weimin 
Published: January 2022

Significance Statement
Vitamin C levels decline in patients with various kidney diseases, but the role of the vitamin as an epigenetic regulator in the initiation and progression of kidney diseases has not been characterized. Using Gulo
−/− mice, which, like humans, entirely depend on dietary vitamin C, we applied single-cell RNA sequencing, whole genome bisulfite sequencing, and methylated RNA immunoprecipitation sequencing to create the first comprehensive renal cell type–specific transcriptional and DNA/RNA methylation profiles. Vitamin C deficiency induced acute tubular necrosis (ATN) and remodeled DNA/RNA epigenetic modifications in a cell type–specific manner. Cisplatin-induced ATN and AKI had similar transcriptional profiles as Gulo
−/− mice. An oxidation-resistant vitamin C derivative, APM, can prevent kidney injuries in cisplatin-induced ATN mice. These findings will aid development of vitamin C as an epigenetic therapy for kidney diseases.

Background
Vitamin C deficiency is found in patients with variable kidney diseases. However, the role of vitamin C as an epigenetic regulator in renal homeostasis and pathogenesis remains largely unknown.

Methods
We showed that vitamin C deficiency leads to acute tubular necrosis (ATN) using a vitamin C–deficient mouse model (Gulo knock-out). DNA/RNA epigenetic modifications and injured S3 proximal tubule cells were identified in the vitamin C–deficient kidneys using whole-genome bisulfite sequencing, methylated RNA immunoprecipitation sequencing, and single-cell RNA sequencing.

Results
Integrated evidence suggested that epigenetic modifications affected the proximal tubule cells and fenestrated endothelial cells, leading to tubule injury and hypoxia through transcriptional regulation. Strikingly, loss of DNA hydroxymethylation and DNA hypermethylation in vitamin C–deficient kidneys preceded the histologic sign of tubule necrosis, indicating the causality of vitamin C–induced epigenetic modification in ATN. Consistently, prophylactic supplementation of an oxidation-resistant vitamin C derivative, ascorbyl phosphate magnesium, promoted DNA demethylation and prevented the progression of cisplatin-induced ATN.

Conclusions
Vitamin C played a critical role in renal homeostasis and pathogenesis in a mouse model, suggesting vitamin supplementation may be an approach to lower the risk of kidney injury.
The Effectiveness of Lugol on the Increasing of Pregnancy Rate in Aceh Cow with Endometritis
Authors: Sutriana Amalia , Sayuti Arman , Panjaitan Budianto , TR Teuku Armansyah , Tunnisa Aisyah Fadillah , Melia Juli , Siregar Tongku Nizwan , Hafizuddin Hafizuddin , Aliza Dwinna 
Published: January 2022

ABSTRACT. The objective of this study was to determine the effect of lugol on the increasing the pregnancy rate in repeat breeding (RB) Aceh cows due to endometritis. This study used six endometritis’s cows, aged 5-7 years, weighed 150-250 kg which were divided into two groups (n=3), KI and KII. The cows in group 1 (K1) were injected with 5 ml PGF2α, while the cows in group 2 (KII) were treated with 50 ml of 2% lugol intra-uterine and continued with an injection of 5 ml PGF2α after healing. The detection of estrus was performed twice a day following by artificial insemination (AI) about 10-16 hours after the onset of estrus. Determination of pregnancy was performed by ultrasonography (USG) on the 25th day after AI. The data obtained were analyzed descriptively. The results showed that all endometritis ’cows in KI and KII present estrous signs (100%). However, only one cow was recovered in K2, whereas in K1 did not. After AI, one pregnant cow was observed in KII (33.3%), while none of the pregnant cows was found in K1 (0.0%). It is concluded that the lugol treatment for endometritis’s Aceh cows can improve the pregnancy rate. (Efektivitas larutan lugol untuk meningkatkan persentase kebuntingan pada sapi Aceh yang mengalami endometritis) ABSTRAK. Penelitian ini bertujuan mengetahui pengaruh pemberian larutan lugol terhadap peningkatan persentase kebuntingan sapi Aceh yang mengalami RB. Dalam penelitian ini digunakan enam ekor sapi Aceh betina dewasa, umur 5-7 tahun, bobot badan 150-250 kg, sudah pernah beranak, dan didiagnosis mengalami endometritis. Seluruh sapi dibagi menjadi dua kelompok (n=3). Pada kelompok 1 (K1), sapi endometritis diterapi dengan 50 ml lugol 2% secara intra uteri dan setelah sembuh dilanjutkan dengan penyuntikan 5 ml PGF2α. Sapi pada kelompok 2 (K2) hanya diinjeksi dengan 5 ml PGF2α. Deteksi berahi dilakukan sebanyak dua kali per hari dan inseminasi buatan (IB) dilakukan sekitar 10-16 jam setelah awal berahi. Pemeriksaan kebuntingan dilakukan dengan ultrasonografi (USG) pada hari ke-25 setelah IB. Data dianalisis secara deskriptif. Dari masing-masing kelompok, hanya satu ekor sapi pada K2 yang dinyatakan sembuh yaitu sapi pada kelompok kedua. Persentase sapi yang menjadi estrus pada kedua kelompok masing-masing adalah 100%. Dari tiga ekor sapi yang diinseminasi pada masing-masing kelompok, hanya satu ekor sapi pada K2 (33,3%) yang menunjukkan hasil positif bunting sedangkan pada K1 tidak terdapat sapi yang menunjukkan hasil positif (0,0%). Disimpulkan bahwa pemberian larutan lugol pada sapi Aceh yang mengalami endometritis dapat meningkatkan persentase kebuntingan sapi Aceh.
Ten Years of SOPHIA
Authors: Powers Gina , Stone Cynthia 
Published: January 2022

In 2021, the Society of Practitioners of Health Impact Assessment (SOPHIA) celebrates its 10-year anniversary. As part of the celebration, we asked founding SOPHIA members and key SOPHIA leaders to reflect on the organization’s formation in 2011, to share their thoughts on SOPHIA’s key challenges and to highlight important accomplishments. Respondents also weighed in on the future of SOPHIA and the value of SOPHIA membership. Research was conducted using written surveys, interviews, and review of written material.
Surveys were sent in July of 2021 to eleven active SOPHIA members, many of whom have served as president, vice president, board member or founding member for SOPHIA. Of the eight survey recipients who were interviewed or completed the written survey, nearly all have been conducting Health Impact Assessments (HIAs) for 10 or more years. Survey respondents’ HIA experience included assessments focused on a variety of policies, projects and programs, including housing, land use, economic security, the built environment, transportation, immigration policies, minimum wage policies, criminal justice and more. This article includes information gleaned through written material review; however, it is largely based on the feedback, insights and experiences shared by survey respondents verbally and in writing.
A Comparative Study to Evaluate the Effect of Norepinephrine and Phenylephrine in the Treatment of Post Spinal Hypotension for Caesarean Section
Authors: Patil Archita , Chavan Rashmee , Mudalagirigowda Shwetha K. , Adda Sravya 
Published: January 2022

Background: Maternal hypotension due to spinal anaesthesia in caesarean section is commonly seen. Alongwith fluid loading, phenylephrine is used to manage the hypotension. However, this drug is associated with cardiovascular side effects.
Methods: This is a prospective double blinded study which was conducted on 100 term parturients scheduled from elective caesarean section under spinal anaesthesia, randomly assigned into two groups. After spinal anaesthesia patients of group N and P were treated with norepinephrine (5mcg) and phenylephrine (50mcg) respectively as an IV bolus for hypotension. Blood pressure, heart rate, number of bolus doses given, and neonatal APGAR score was noted.
Results: Patients of both groups were comparable with respect to haemodynamic parameters (HR, SBP, DBP, AND MAP). Incidence of bradycardia was higher in group P (22%, n=11) compared to group N (14%, n=7). Neonatal APGAR scores at different time intervals were similar in both groups.
Conclusion: Intermittent boluses of norepinephrine were effective in the treatment of spinal anaesthesia induced hypotension during caesarean section and can be considered as an alternative to phenylephrine.
Surfactant Utilization Evaluation in a Major Teaching Hospital in West of Iran: An Observational, Prospective Study
Authors: Khiali Sajad , Hosseini Mohammadbagher , Shaseb Elnaz 
Published: January 2022

Background: The respiratory distress syndrome (RDS) is a common pulmonary disorder that usually occurs as a result of preterm labor and is associated with lack of surfactant. The aim of this study was to evaluate the pattern of surfactant prescription in Alzahra teaching hospital in Tabriz, Iran.
Methods: This drug use evaluation (DUE) study was conducted in the neonatal intensive care unit (NICU) of Al-Zahra Hospital, Tabriz, Iran. The demographic and clinical data collection was performed using clinical records of patients. The pattern of surfactant replacement therapy was evaluated and compared with the European Consensus Guideline on the management of respiratory distress syndrome in 2016.
Results: A total of 252 premature infants who received surfactant between August 2017 and March 2018 were included. 80.8% of neonates were born by cesarean section. The most used surfactant was Curosurf®, which was used in 82.1% of cases. Only 34.9% of the infants received within 8 hours of birth. Moreover, 79% of infants received the standard dose of surfactant, while 9.5 % and 11.5% were given high and low doses of surfactant, respectively.
Conclusion: The pattern of surfactant replacement therapy was not completely according to the guidelines, particularly regarding the time of administration. Considering the importance of dose and timely administration of surfactant, providing strategies to decrease these errors are important.
Oxidative Stress and Bipolar Mood Disorder: An Important Yet Ambiguous Relationship
Authors: Rahsepar Sara , Mohammadpour Amirhooshang 
Published: January 2022

Bipolar disorder is a chronic psychological condition that disturbs many patients' lives around the world. The exact pathophysiology of bipolar disorder is yet unknown, but there are several hypotheses to explain this condition. One of the most challenging theories is the role of oxidative stress in the progression of bipolar disorder. Here, we conducted a narrative review to gather the studies that investigated the relationship between bipolar disorder and oxidative stress. We searched PubMed, Scopus, Web of science, and google scholar databases using the following keywords: “bipolar disorder,” “oxidative stress,” “oxidative markers,” and “bipolar patients.” A majority of studies showed that oxidative markers such as Thiobarbituric acid reactive substances are significantly higher in bipolar patients compared to healthy subjects. Based on the included articles, bipolar disorder is associated with oxidative stress. Nevertheless, further well-established Cohorts are required to support these results.
COVID-19 Salgınının Kadınlarda Eş Uyumu ve Cinsel Yaşam Kalitesine Etkisi
Authors: GÖKBULUT Nilay , BAL Zeynep , UÇAR Tuba 
Published: January 2022

ÖZET
AMAÇ: Bu çalışmanın amacı, COVID-19 salgınının kadınlarda eş uyumu ve cinsel yaşam kalitesine etkisini incelemektir.
MATERYAL METOT: İnternet tabanlı kesitsel tipte olan bu çalışma, web tabanlı bir çevrimiçi anket kullanılarak yürütüldü. Araştırmada anket formları 15 Haziran-15 Ağustos 2020 tarihleri arasında sosyal medya aracılığıyla 386 kadına uygulandı. Anket formunda kadınların sosyodemografik özellikleri, COVID-19 pandemisinde cinselliğe ilişkin bilgileri içeren sorular, Yenilenmiş Çift Uyum Ölçeği (YÇUÖ) ve Cinsel Yaşam Kalitesi Ölçeği-Kadın (CYKÖ-K) yer aldı.
BULGULAR: Kadınların %73,8’i COVID-19 pandemisinde eş ilişkilerinin olumsuz etkilenmediğini, %71,8’i cinsel yaşamının olumsuz etkilenmediğini belirtti. Eş ilişkisi ve cinsel yaşamının olumsuz etkilendiğini ifade eden kadınların YÇUÖ toplam, Uzlaşım ve Görüş Birliği alt boyutları puan ortalamalarının, eş ilişkisi ve cinsel yaşamının olumsuz etkilenmediğini ifade eden kadınlardan daha düşük olduğu ve gruplar arasındaki farkın istatistiksel olarak anlamlı olduğu belirlendi (p
Fascismo no Século XXI?
Authors: Souza Angelita Matos 
Published: January 2022

Em 2021, duas obras fundamentais para se entender o fenômeno do fascismo foram lançadas no Brasil: Fascismo e grande capital, de Daniel Guérin, publicada pela primeira vez no país, pela Editora da Unicamp; e Fascismo e ditadura, de Nicos Poulantzas, uma reedição muito cuidadosa da Editora Enunciado.
Microbial Community Shift and Role of Bacteria in Rapid Granulation By Using Diatomite
Authors: Basri Hazlami Fikri , Anuar Aznah Nor , Halim Mohd Hakim Abdul 
Published: January 2022

Abstract
Aerobic granular sludge (AGS) technology is a promising biological method for modern wastewater treatment. However, granulation time have become a major issue for the application of AGS technology especially in low strength wastewater. Recent studies on granulation are focusing towards rapid start-up granulation process. Diatomite, a friable light-coloured sedimentary rock was introduces in this study to enhanced the granules formation. This study highlight the effect of diatomite towards the microbial community during the transformation of seed sludge until development of granules. DNA extraction and Metagenomic analysis was conducted with three samples (seed sludge, control AGS, AGS diatomite) to compare the microbial community. The microbial community analysis revealed the alpha diversity, phylum and class level, and the abundance of EPS producing bacteria of each bacteria samples respectively. Diatomite has a significant influence towards the microbial diversity (High Shannon index alpha diversity). Also, diatomite promotes the abundance of functional bacteria especially EPS producing bacteria, which seen as a crucial elements in granulation process.
Novel Herbal Formulation Jing Si Exhibits Multiple Functions to Inhibit Replication Activity and Subsides Viral Load of COVID-19 Variants
Authors: Lin Yu-Jung , Chiang Chien-Yi , Shibu Marthandam Asokan , Su San-Hua , Dass Kingsley Theras Primus , Lin Pi-Yu , Lin Shinn-Zong , Ho Tsung-Jung , Kuo Wei-Wen , Huang Chih-Yang 
Published: January 2022

Abstract
Background: SARS-CoV-2 is susceptible to frequent mutations and gets transformed into variants therefore identifying novel multi targeting remedies is necessary in formulating strategies to overcome the pandemic. Methods: Traditional Chinese medicine based formula Jing Si herbal (JSH) was screened and analyzed by HPLC to evaluate its ability to act against infection by SARS-CoV-2 variants. The 3CL protease and RdRp assay kit were utilized to detect the enzyme activity. In order to determine the effect of JSH on the binding efficiency and viral penetration of SARS-CoV-2 variants, Calu-3 lung cells and Caco-2 colon cells were infected with fluorescent SARS-CoV-2 pseudo type lentiviruses. In addition, the effect of JSH (16.22 mg /mice/day and 48.66 mg/mice/day) on the viral load in SKH1J mice exposed to inhalation of luminescent SARS-CoV-2 variants for three days was determined. Results: The JSH was found to be effective in inhibiting the viral entry into Calu-3 and Caco-2 cells and in mice pre-treated with JSH for 3 days also inhibited the viral load exposed to different SARS-CoV-2 variants. Interestingly, JSH also decreased 3cL and RdRp activity thereby revealing the multi targeting nature of JSH and therefore will be a potential preventive SARS-CoV-2 infection.Conclusion: Taken together, our present results revealed that JSH could be a potential candidate for COVID-19 treatment.
Clinical Manifestations, Outcomes, and Histopathology of Recurrent Uveitis in Patients Underwent Pupil Coroplasty Combined with Cataract Surgery
Authors: Lu Hui , Chen Doudou , Zhu Siquan 
Published: January 2022

Abstract
Purposes: This study was aimed to evaluate the clinical manifestations of recurrent uveitis in patients underwent pupil coroplasty combined with cataract surgery, and discovery the histopathological changes of iris tissues. Methods: There 28 patients with recurrent uveitis-induced cataract, who had underwent pupil coroplasty, phacoemulsification, and intraocular lens implantation were enrolled in this study. The clinical manifestations and outcomes of the enrolled patients were analyzed. The histopathological changes of iris tissues were observed by hematoxylin and eosin (HE) staining. Results: The uveitis were idiopathic in 89.29% cases (n = 25). Before the surgery, 20 cases had no topical medication for at least 3 months. The preoperative BCVA was > 0.5 in all cases. During the follow-up of 5-10 years, no recurrence of uveitis was found in 96.43% cases (n = 27). Uveitis only recurred in one case along with the onset of ankylosing spondylitis at the 6th week after the surgery. HE staining showed obvious atrophy of iris stroma in all samples. The hyperplasia of pigment cells was observed in the pigment epithelium (n = 9) and even invaded into stroma (n = 19). The infiltration of inflammatory cells in iris tissues was found in 7 cases, and neovascularization in the surface of the iris was found in 2 cases. Conclusion: Recurrent uveitis was characterized by the atrophy of iris stroma, and some cases also exhibited hyperplasia of pigment cells and infiltration of inflammatory cells. The surgery proposed in this study can effectively prevent the long-term recurrence of uveitis.
Bilateral Subthalamic Nucleus Deep Brain Stimulation for Refractory Isolated Cervical Dystonia
Authors: Yin Feng , Zhao Mingming , Yan Xin , Li Tong , Chen Hui , Li Jianguang , Cao Shouming , Guo Hui , Liu Shuang 
Published: January 2022

Abstract
Subthalamic nucleus (STN) deep brain stimulation (DBS) has been proven to be an alternative target choice for refractory isolated cervical dystonia (CD). However, assessments of its short and long-term safety, efficacy, and sustained effectiveness have been limited to few reports. Here, we evaluated nine consecutive refractory isolated CD patients who underwent bilateral STN DBS and accepted to short and long-term follow-up in this retrospective study. Seven time points were used to see the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) scores (pre-operation [baseline], 1, 3, 6, 12, 24 months post-operation and last follow-up) to assess improvement of dystonic symptoms. The 36-item Short-Form General Health Survey (SF-36) scores obtained at pre-operation and last follow-up to assess the changes in quality of life. All patients tolerated surgery well and acquired observable clinical benefits from STN DBS therapy. All patients achieved a considerable improvement in quality of life at the last follow-up. The hardware-related adverse events can be tolerated and the stimulation-related adverse events can be ameliorated by programming. Our data support the idea that bilateral STN DBS is a safety and effective method for the treatment of refractory isolated CD, with persistent and remarkable improvement in both movement and quality of life.
EGFL6 Promotes Bone Metastasis of Lung Adenocarcinoma by Enhancing Osteoclast Differentiation and Stimulating Cancer Cell Metastasis
Authors: Song Xiaoting , Cheng Xu , Jin Xiangang , Ruan Shengyu , Xu Xianquan , Lu Feng , Wu Xinhui , Lu Fangying , Feng Mingxuan , Zhang Liwei , Ge Renshan , Chen Haixiao , Hong Zhenghua , Hong Dun 
Published: January 2022

Abstract
Background
Lung cancer is still the most fatal cancer today with approximately 30%-40% of these patients will develop bone metastasis. Lung adenocarcinoma (LUAD) is the most common and aggressive type of lung cancer. The relationship between LUAD and bone metastasis and its underlying mechanism remains unclear. This study proved that epidermal growth factor-like domain multiple 6 (EGFL6) was highly expressed in LUAD specimens of patients, and the expression level was positively correlated with bone metastasis of LUAD.
Method
The expression of EGFL6 in cancer tissues was detected by IHC. CCK-8, colony formation assay, migration and invasion assay, wound healing assay, immunocytochemistry, RT-PCR, Western blotting, ELISA, bone resorption, TRAP staining and H&E staining were performed. A nude mouse model of LUAD-induced bone destruction was established by injecting A549 cells in different EGFL6 expression levels.
Results
EGFL6 is elevated in LUAD and is associated with bone metastasis. In vivo, implantation of human adenocarcinoma A549 cells with a higher expression of EGFL6 not only increased tumor growth rate but also bone resorption of tibias in nude mice. In vitro, the secretion of EGFL6 from A549 cells increased osteoclast differentiation but had little effect on osteogenic differentiation. To reveal the underlying mechanism, we demonstrated that EGFL6 enhanced osteoclast differentiation through activating nuclear factor-kappa B (NF-κB) and downstream c-Fos/NFATc1 signaling pathways, and in addition promoted the proliferation, migration and invasion of A549 cells through enhancing the epithelial mesenchymal transformation (EMT) and promoting Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways.
Conclusions
We unveil EGFL6 as a predictor in bone metastasis of LUAD and underscore the relevance of EGFL6 as a therapeutic target.