bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polysilsesquioxane-modified Cellulose Insulating Paper with Excellent Mechanical Properties, Electrical Properties and Aging Resistance
Authors: Li Chengen , Yang Lu , Wang Zuhao , Tang Chao 
Published: November 2022

Abstract
Nano-modified insulating paper is regarded as a promising material in power systems due to its outstanding performance. In this paper, three kinds of polysilsesquioxane nanoparticles with different substituents (octaaminophenyl POSS, octaphenyl POSS, and octamethyl POSS) were used to prepare modified cellulose insulating paper. It was found that the doping of polysilsesquioxane nanoparticles could effectively improve the tensile strength of insulating paper and reduce its relative dielectric constant. Specifically, doping of 10 wt% octaaminophenyl POSS (OAPS) showed the best modification effect. On this basis, accelerated thermal aging test was carried out on the 10 wt% OAPS modified insulating paper. Compared with the unmodified sample, the tensile strength of the modified sample increased by 16.87% and the relative dielectric constant decreased by 24.63% after aging at 130 ℃ for 31 days. Molecular simulation technology was used to study the micro mechanism and results show that OAPS can significantly improve the tensile strength, dielectric properties and thermal stability of cellulose insulating paper by forming hydrogen bonds with cellulose chains, reducing the system polarizability and the movement strength of cellulose chains.
Metabolomic profiling in kidney cells treated with a sodium glucose-cotransporter 2 inhibitor
Authors: Jo Hyung Ah , Seo Jong-Hyun , Lee Sunhwa , Yu Mi-yeon , Bae Eunjin , Kim Dong Ki , Kim Yon Su , Kim Da Jung , Yang Seung Hee 
Published: November 2022

Abstract
We aimed to determine the metabolomic profile of kidney cells under high glucose conditions and following sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment. Targeted metabolomics using the Absolute IDQ-p180 kit was applied to quantify metabolites in kidney cells stimulated with high glucose (25 and 50 mM) and treated with SGLT2 inhibitor, dapagliflozin (2 µM). Primary cultured human tubular epithelial cells, podocytes, and glomerular endothelial cells were used to identify the metabolomic profile in high glucose conditions following dapagliflozin treatment. The levels of asparagine, PC ae C34:1, and PC ae C36:2 were elevated in tubular epithelial cells stimulated with 50 mM glucose and were significantly decreased after 2 µM dapagliflozin treatment. The level of PC aa C32:0 was significantly decreased after 50 mM glucose treatment compared with the control, and its level was significantly increased after dapagliflozin treatment in podocytes. The level of arginine in glomerular endothelial cells was decreased after stimulation with 50 mM glucose, whereas dapagliflozin treatment significantly elevated its level. The differentially expressed metabolites in kidney cells stimulated by the SGLT2 inhibitor under high glucose conditions were distinct according to cell types.
Impact of Activation Energy and Variable Properties on Peristaltic Flow through Porous Wall Channel
Authors: Rafiq Maimona , Shaheen Asma , Khedher Nidhal Ben , Tag-ElDin Sayed Mohamed , Khan M. Ijaz 
Published: November 2022

Abstract
The current study discusses the peristaltic flow of Jeffrey fluid through a porous wall channel. Magnetohydrodynamic (MHD) effects are also considered while formulating the problem. Heat and mass transfer are discussed in the presence of activation energy constant heat source/sink effects. A Chemical reaction is also part of the analysis. The Lubrication approach is adopted for the simplification of resulting non-linear equations. MATHEMATICA command, NDSolve, is used to discuss the results graphically. Parabolic behavior is noticed for velocity. The decreasing trend is shown by concentration when the value of the chemical reaction parameter is enhanced.
Guilt Emotion Modulates Social Attention Orienting Triggered by Eye Gaze
Authors: Zhao Wen , Yang Jiajia , Hu Zhonghua 
Published: November 2022

Abstract
Gaze direction can trigger social attentional orientation, characterised by an enhancement of the reaction in detecting targets appearing in a gazed-at location compared with those appearing in other locations, called the gaze-cueing effect. Here, we investigated whether a feeling of guilt established from prior interaction with a cueing face could modulate the gaze-cueing effect. Participants first completed a guilt-induction task using a modified dot-estimation paradigm to associate the feeling of guilt with a specific face, and then the face that established the binding relationship was used as the stimulus in a gaze-cueing task. The results showed that guilt-directed faces and control faces induce equal magnitudes of gaze-cueing effect in 200 ms stimulus onset asynchrony (SOA), while guilt-directed faces induce a smaller gaze-cueing effect than control faces in 700 ms SOA. These findings provide first evidence for the role of guilt emotion on social attention triggered by eye gaze.
The genetic basis of grain protein content in rice by genome-wide association analysis
Authors: Chen Pingli , Lou Guangming , Wang Yufu , Chen Junxiao , Chen Wengfeng , Fan Zhilan , Liu Qing , Sun Bingrui , Mao Xingxue , Yu Hang , Jiang Liqun , Zhang Jing , Lv Shuwei , Xing Junlian , Pan Dajian , Li Chen , He Yuqing 
Published: November 2022

Abstract
The grain protein content (GPC) of rice is an important factor that determines its nutritional, cooking, and eating qualities. To date, some genes affecting GPC have been identified in rice, most of which have been cloned using mutants. A few genes controlling rice GPC have been cloned in the natural population. Here, 135 significant association loci were detected in a genome-wide associated study (GWAS), and many loci could be repeatedly detected across different years and populations. Four minor quantitative trait loci affecting rice GPC at four significant association loci, qPC1.1, qPC1.2, qPC1.3, and qPC1.4, were further validated in near-isogenic line F2 populations (NIL-F2), and explained 9.82, 43.4, 29.2, and 13.6% of the phenotypic variation, respectively. The associated flo5 knockdown mutation simultaneously increased the grain chalkiness rate and GPC. Three candidate genes in a significant association locus region were analyzed using haplotype and expression profiles. The findings of this study will contribute to the cloning of rice GPC genes to elucidate the genetic regulatory network of protein synthesis and accumulation in rice, and provide new dominant alleles for marker-assisted selection in the genetic improvement of rice grain quality.
Optimization of the cutting tool geometry when milling aluminum honeycomb structures
Authors: Zarrouk Tarik , Salhi Jamal-Eddine , Nouari Mohammed , Salhi Merzouki , Kodad Jalal 
Published: November 2022

Abstract
The manufacture of aluminum honeycomb structures is a major concern for companies in the aerospace industry, due to its high out-of-plane strength and stiffness-to-weight ratio. However, the shaping of this type of structure represents a technical challenge for engineers and researchers in terms of premature wear of the cutting tool and the quality of the machined surface. The analysis of the parameters influencing the machinability of this type of structure is often based on empirical tests. However, the experimental procedure fails to visualize the mechanism of cut formation due to the high rotational speed of the cutting tool. Consequently, it is then necessary to use reliable numerical models to access instantaneous and much localized physical quantities. To this end, we have developed a 3D finite element model associated with real working conditions using the Abaqus/Explicit analysis software. Based on this model, an experimental validation was carried out by analyzing the appropriate behavior laws. Furthermore, the influence of the geometry of the cutting tool in terms of the number of teeth on the size of the chips, the cutting forces and the quality of the generated surface was analyzed. The results obtained show that the integrity of the cutting tool can be optimized and the quality of the machined surface can be improved.
Assessing the effect of age at sexual debut on HIV acquisition among Adolescents Girls and Young Women in Malawi: Evidence from Malawi Population-based HIV Impact Assessment
Authors: Moyo Reuben Christopher , Nyasulu Peter Suwilakwenda , Govindasamy Darshini 
Published: November 2022

Abstract
Background
Adolescent girls and young women (AGYW) constitute the highest proportion of all new HIV infections in sub-Saharan Africa. Age at sexual debut is one of the sexual behavior factors that predict HIV among AGYW. We aim to assess the effect of age at sexual debut on HIV acquisition among AGYW in Malawi using 2016 Malawi population-based HIV impact assessment (MPHIA).
Methods
We analyzed HIV data on 1,921 AGYW from the 2016 MPHIA. Associations between HIV infection and predictor variables were assessed using both univariate and multivariate logistic regression. The effect of age at sexual debut on HIV acquisition was assessed using binary logistic regression model with random adjustment of standard errors.
Results
The weighted HIV prevalence among AGYW was estimated at 4.7%. The prevalence was high for AGYW from southern region (7.8%) compared to the central (2.3%) and the northern region (2.1%). AGYW from urban areas had twice as much the prevalence of HIV compared to those from rural areas (9.1% versus 3.7% for urban and rural respectively). This study has identified 9 behavior and contextual factors that are associated with HIV infection among AGYW, and these are: region (p < 0.001), residence (p < 0.001), age (p = 0.008), age at first sex (p = 0.001), age at marriage (p0.0131), marital status (p < 0.001), education (p = 0.002), wealth quintile (p = 0.05) and partner at last sex (p < 0.001). AGYW who started sex before the age of 15 were more than two times (OR 2.47, 95% CI 1.52–4.05) likely to be test HIV positive compared to those who started after the age of 15.
Conclusion
This study concludes that early sexual debut occurring before the age of 15 significantly predict HIV among AGYW in Malawi. To reduce their risk to acquiring HIV, such AGYW should be linked to HIV PreP services to minimize risk of HIV transmission.
Numerical investigation on diffusion length, suspending time, and forces acting on COVID-19 virus particles in an indoor environment
Authors: Dehaghi Mahdi Bagherian 
Published: November 2022

Abstract
The purpose of this study is to study two-dimensional CFD simulations of the COVID-19 virus two-phase flow in steady air with the Euler-Lagrange method. This was accomplished by developing CFD programs in MATLAB and simulations in COMSOL software. Brownian, drag, Saffman, and weight forces are considered for studying the dynamics of virus flow. In order to study the motion of viruses, Brownian, drag forces, and the weight of viruses play an important role. In this study, three different diameters of virus particles were considered, with three different initial conditions and three different initial velocities. The diffusion length and suspending time of viruses in the air have been computed in each of the nine states.
Ketamine alleviates fear memory and spatial cognition deficits in PTSD rat model via BDNF signaling pathway of hippocampus and amygdala
Authors: Sun Lin , Niu JiaYao , Teng Yue , Liu Yang , Wang Han , Chen JinHong , Kong YuJia , Wang Ling , Lian Bo , Sun HongWei , Wang WeiWeng 
Published: November 2022

Abstract
Post-traumatic stress disorder (PTSD) is associated with traumatic stress experiences. This condition can be accompanied by learning and cognitive deficits, contributing to increased rates of disability in people with PTSD. Studies have shown that that ketamine can rapidly and significantly alleviate symptoms in patients with chronic PTSD. Nevertheless, the effects of ketamine on neurocognitive impairment and its mechanism of action in PTSD remain unclear. In this study, the gradient dose-related effects of ketamine (5, 10, 15, and 20 mg/kg, i.p.) on spatial and fear memory were evaluated in a rat model of single prolonged stress and electric foot shock (SPS&S). Expression levels of brain-derived neurotrophic factor (BDNF) and post-synaptic density-95 (PSD-95) in the hippocampus (HIP) and amygdala (AMG) were determined by Western blot analysis, immunohistochemistry, and quantitative real-time PCR assays. The data showed that rats subjected to SPS&S exhibited significant PTSD-like cognitive impairment.The effect of ketamine on SPS&S-induced neurocognitive function showed a U-shaped dose effect in rats. A single administration of ketamine at a dosage of 10 ~ 15mg/kg resulted in significant changes in behavioral outcomes. And these improvements in cognitive function and molecular changes were reversed at high doses (15 ~ 20mg/kg). Overall, Ketamine reversed SPS&S-induced fearand spatial memory impairment and down-regulation of BDNF and BDNF-related PSD-95 signaling in the HIP and AMG. And the dose of 15 mg/kg reversed behavioral and molecular changes rapidly, and promoted the amelioration of cognitive dysfunction. The enhanced association of BDNF signaling with PSD-95 influences could participate in the therapeutic efficiency of ketamine for PTSD.
Selective targeting of lectins and their macropinocytosis in urothelial tumours: translation from in vitro to ex vivo
Authors: Resnik Nataša , Višnjar Tanja , Smrkolj Tomaž , Kreft Mateja Erdani , Romih Rok , Zupančič Daša 
Published: November 2022

Abstract
Urinary bladder cancer can be treated by intravesical application of therapeutic agents, but the specific targeting of cancer urothelial cells and the endocytotic pathways of the agents are not known. During carcinogenesis, the superficial urothelial cells exhibit changes in sugar residues on the apical plasma membranes. This can be exploited for selective targeting from the luminal side of the bladder. Here we show that the plant lectins Jacalin (from Artocarpus integrifolia), ACA (from Amaranthus caudatus) and DSA (from Datura stramonium) selectively bind to the apical plasma membrane of low-grade (RT4) and high-grade (T24) cancer urothelial cells in vitro and urothelial tumours ex vivo. The amount of lectin binding was significantly different between RT4 and T24 cells. Endocytosis of lectins was observed only in cancer urothelial cells and not in normal urothelial cells. Transmission electron microscopy analysis showed macropinosomes, endosome-like vesicles and multivesicular bodies filled with lectins in RT4 and T24 cells and also in cells of urothelial tumours ex vivo. Endocytosis of Jacalin and ACA in cancer cells was decreased in vitro after addition of inhibitor of macropinocytosis 5-(N-ethyl-N-isopropyl) amiloride (EIPA) and increased after stimulation of macropinocytosis with epidermal growth factor (EGF). Clathrin, caveolin and flotillin did not colocalise with lectins. These results confirm that the predominant mechanism of lectin endocytosis in cancer urothelial cells is macropinocytosis. Therefore, we propose that lectins in combination with conjugated therapeutic agents are promising tools for improved intravesical therapy by targeting cancer cells.
Clinical and oncological outcomes of transanal total mesorectal excision considering the embryology along the fascia in rectal cancer patients: a propensity score-matched analysis
Authors: Yoshimitsu Kohei , Mori Shinichiro , Tanabe Kan , Wada Masumi , Hokonohara Kentaro , Hamada Yuki , Yasudome Ryutaro , Kurahara Hiroshi , Arigami Takaaki , Sasaki Ken , Matsushita Daisuke , Shimonosono Masaki , Koriyama Chihaya , Higashi Michiyo , Nakajo Akihiro , Ohtsuka Takao 
Published: November 2022

Abstract
Purpose
Transanal total mesorectal excision (TaTME) remains a challenging technique for rectal dissection. This study aims to evaluate the clinical and oncological outcomes of TaTME, compared to those of the laparoscopic total mesorectal excision (LaTME) in rectal cancer.
Methods
Using propensity score-matched analyses, we analyzed retrospective data from 134 consecutive patients with rectal cancer who underwent TaTME or LaTME from January 2011 to June 2020 in our hospital. Clinical and oncological outcomes were evaluated. The primary endpoint was the 2-year local recurrence rate.
Results
Before data analysis, significant group-dependent differences were observed only in the tumor height (p < 0.01). After analysis, preoperative patients’ demographics were similar between the TaTME and LaTME-defined groups. The operative time was significantly shorter in the TaTME group (p = 0.02), and the rates of hand-sewn anastomosis and protective loop ileostomy were significantly higher(p < 0.01). TaTME showed a 29% overall morbidity rate and LaTME 44%. Furthermore, the rate of Clavien–Dindo grade III tended to be lower in the TaTME group (p = 0.07). There were no statistically significant differences in terms of pathological findings, and the 2-year local recurrence rate was similar between the two groups (both 5.9%)
Conclusions
TaTME based on embryology along the fascia is feasible and seems a safe alternative to LaTME in selected patients with rectal cancer when considering the conversion rate and the operative time.
Effect of Mammalian Sex Hormones on Wheat Mature Embryo Culture
Authors: Otaran Esra , Çağlar Özcan , Haliloğlu Kamil , Bulut Sancar , Erayman Mustafa 
Published: November 2022

Abstract
Mammalian sex hormones (MSHs) are synthesized by various plant species and known play critical roles in growth, development, and reproduction. External and endogenous use of MSHs resulted in different response in different plant species. However, effects of different MSHs with concentrations on different wheat genetic backgrounds have not been studied in vitro. Therefore, three wheat cultivars (cvs. Palandöken 97, Nenehatun, Kırik) and four MSHs (17 β-estradiol, estrogen, progesterone, and testosterone) with three concentrations of 10-4, 10-5, 10-6 mM were used to investigate callus formation and embryonic callus formation rates as well as number of regenerated plants. Our results showed that wheat genotypes were significantly influenced by the type of MSH and its concentration. In addition, effect of hormones may vary with respect to growth or development of cells or plants. The highest callus formation rate was obtained on cv. Palandöken 97 with 10-4 mM testosterone hormone. Embryogenic callus formation rate with respect to number of explants was the highest on Palandöken 97 in 17β-estradiol with 10 -4 mM while embryogenic callus formation rate with respect to number of calli was the highest on cv. Kırik in progesterone and 10-4 mM concentration. On the other hand, the highest regenerated plants were observed on cv. Palandöken 97 in 10-6 mM 17β-estradiol and 10-6 Mm progesterone. Such contrasting results may indicate the potential utilization of suitable wheat genotypes, MSHs and doses in wheat tissue culture which is a prerequisite in wheat transformation experiments.
Cross-lagged Analysis of Problematic Social Media Use and Phubbing Among College Students
Authors: Lv Shuai , Wang Hui 
Published: November 2022

Abstract
Background
Phubbing is a commonly-seen phenomenon that has emerged in recent years among groups of college students, posing a rising challenge to educators. We conduct a research in which reciprocal relationship between problematic social media use and phubbing is explored and analyzed quantitatively, aiming at discovering reliable theoretical support to work out an appropriate intervention on students’ phubbing for students’ mental health concerns.
Methods
Using the Problematic Social Media Use Scale (PSMUS) and the Phubbing Scale (PS), 328 college students from four universities in Shandong province were enrolled in a two-stage longitudinal follow-up study for 20 months from December 2019 to August 2021. A cross-lagged model was constructed to explore the reciprocal relationship between problematic social media use and phubbing. The results of correlation analysis showed that problematic social media use was positive correlated with phubbing at both time points(r = 0.51, 0.53, P < 0.01);
Results
The results of cross-lag regression analysis showed that, the predictive effect of pretest problematic social media use on posttest problematic social media use was statistically significant(β = 0.24,P < 0.01), there was statistical significance in the prediction effect of pretest phubbing on posttest phubbing (β = 0.16,P < 0.05), pretest problematic social media use had statistical significance in predicting posttest phubbing (β = 0.22,P < 0.01), there was no statistical significance in the prediction of pretest phubbing on posttest problematic social media (β = 0.16,P < 0.05).
Conclusion
Problematic social media use of college students is closely related to phubbing, and problematic social media use can predict phubbing.
DU-Net-Cloud: A Smart Cloud-Edge Application with an Attention Mechanism and U-Net for Remote Sensing Images and Processing
Authors: Kong Jiayuan , Zhang Yanjun 
Published: November 2022

Abstract
In recent ages, the use of deep learning approaches to extract ground object information from remote sensing high-resolution images has attracted extensive attention in many fields. Nevertheless, due to the high similarity of features between roads, prevailing deep learning semantic segmentation networks commonly demonstrate reduced continuity in road segmentation. In order to better study the road details in images related to remote sensing, this paper suggests a road extraction technique which is founded on Dimensional U-Net (DU-Net) network. At the deepening level of U-Net network, a parallel attention mechanism, known as ProCBAM, is added and implemented to the feature transmission step of the U-Net network. Moreover, we use the edge-cloud architecture to develop and construct a unique remote sensing image service system that integrates several datacenters and their related edge infrastructure. The edge network is primarily used for caching and distributing the processed remote sensing images, while the remote datacenter serves as the cloud platform and is responsible for the storage and processing of original remote sensing images. The results show that DU-Net has good performance in road segmentation and can achieve improved road segmentation and resolve the issue of reduced continuity of road segmentation when compared with other state-of-the-art learning networks. We observed that the proposed system not only distributes the workload of processing tasks across the edges but also achieves data efficiency among them, which enhances image processing efficiency and lowers data transmission costs.