bluuebunny/crossref_metadata_2025_split huggingface dataset:
The diagnostic value of exosomal circular RNAs in cancer patients: A systematic review and meta‐analysis
Authors: Zhang Yang , Yang Xuyang , Zhuang Zixuan , Wei Mingtian , Meng Wenjian , Deng Xiangbing , Wang Ziqiang 
Published: July 2022

AbstractBackgroundRecently, serum exosomal circular RNAs (circRNAs) were applied to discriminate cancer patients from healthy individuals, indicating that exosomal circRNAs have the potential to be novel biomarkers for cancer diagnosis. This study aims to summarize the role of exosomal circRNAs in cancer diagnosis by a meta‐analysis.MethodsA comprehensive literature search was conducted up to July 2021 in PubMed, Web of Science, EMBASE, and Cochrane Database. To evaluate the diagnostic value, the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were pooled. Threshold effect followed by subgroup analysis and meta‐regression were performed to explore the source of heterogeneity. Sensitivity analysis was performed to assess the stability of this meta‐analysis model. Fagan plots and likelihood ratio scattergrams were used to explore the potential clinical significance.ResultsTen eligible studies with 514 controls and 557 patients were included in this diagnostic meta‐analysis. The pooled sensitivity, specificity, PLR, NLR, and DOR were 0.75 (95% CI: 0.65–0.83), 0.84 (95% CI, 0.78–0.89), 5.87 (95% CI, 3.67–9.38), 0.28 (95% CI, 0.19–0.40), and 21.15 (95% CI, 10.25–43.68), respectively. The AUC was 0.89 (95% CI, 0.86–0.91). Sensitivity analysis showed that four studies had an impact on the pooled results and mainly contributed to the heterogeneity. Fagan's nomogram revealed that the prior probability of 20%, the post probability positive, the post probability negative were 59% and 6%, respectively.ConclusionOur results suggested that exosomal circRNAs might serve as powerful biomarkers in detecting cancers with high sensitivity and specificity. However, more well‐designed and multicenter diagnostic tests are needed to validate our results.
MoFiM: A morphable fish modeling method for underwater binocular vision system
Authors: Yin Jingfang , Zhu Dengming , Shi Min , Li Zhaoxin , Duan Ming , Mi Xiangyuan , Wang Zhaoqi 
Published: July 2022

AbstractFish morphology is an essential basis for fishery management, as it can reflect the growth status of fishes. Noncontact 3D reconstruction of underwater fish is a new way to obtain fish morphology. While it is difficult to reconstruct fish on account of the inadequate information caused by fish swimming and poor underwater imaging. This article introduces a morphable fish modeling method for the underwater binocular vision system. First, we define a fish representation based on selected landmarks. Then, we propose a chirality‐supervision incorporated hourglass network to estimate fish orientation and fish 2D landmarks simultaneously, and calculate fish 3D landmarks by triangulation. Next, we propose a fish modeling method which is based on 3D landmarks and introduce the optimization procedure of fish modeling. Finally, we obtain the complete 3D fish model corresponding to the input images. To train our network and build a parametric model, we constructed an underwater vision dataset and fish instance dataset respectively. We conducted experiments with grass carp as an example, and the experimental results show that our method can achieve effective fish modeling and is useful for noncontact measurement of underwater fish.
Oxytocin suppresses CXCL10 production in TNF‐α‐stimulated human dental pulp stem cells
Authors: Kumagai Tomoki , Shindo Satoru , Takeda Katsuhiro , Shiba Hideki 
Published: July 2022

AbstractOxytocin (OX) is a posterior pituitary hormone secreted into the blood from axon terminals projecting from the posterior pituitary. Recent reports indicate OX plays an important role in the progression of inflammatory diseases such as rheumatoid arthritis. Pulpitis is caused by the activation of the biological defense mechanism of the dental pulp against cariogenic bacteria. However, the role of OX in the pathogenesis of pulpitis remains unknown. The aim of this study was to examine the effect of OX on CXC chemokine ligand 10 (CXCL10) production in human dental pulp stem cells (HDPSCs). Expression of the oxytocin receptor (OXR) on HDPSCs was detected by Western blot analysis and immunofluorescence. CXCL10 production in HDPSCs was measured using an enzyme‐linked immunosorbent assay kit. Western blot analysis was performed to determine the phosphorylation levels of signal transduction molecules, including nuclear factor kappa B, mitogen‐activated protein kinases (MAPKs), and Akt in HDPSCs. HDPSCs expressed OXR. OX significantly decreased CXCL10 production in tumor necrosis factor (TNF)‐α‐stimulated HDPSCs. The p38 MAPK and Akt pathways were related to the OX‐suppressed CXCL10 production in TNF‐α‐stimulated HDPSCs. These results indicate that OX appears to modulate the immune response in pulpitis via suppression of CXCL10 production by HDPSCs.
Metastatic renal cell carcinoma presenting as a duodenal mass
Authors: Vrakas Spyridon , Skouloudis Epameinondas , Koutoufaris Georgios , Manoloudaki Kassiani , Karapiperis Dimitrios , Xourgias Vasilis 
Published: July 2022

AbstractWe report a case of renal cell carcinoma metastasis to the duodenum.
Successful management of scalp avulsion with full‐thickness graft
Authors: Almoshantaf Mohammad Badr , Swed Sarya , Hajjar Abdulkader , Alshawaf Ala’a , Nabhan Ahmad , Zetani Bayan , Etr Aladdin 
Published: July 2022

AbstractScalp avulsion injuries are one of the life‐threatening traumatic injuries. Rapid management in the emergency department is vital to the successful rescue of an avulsed scalp. There are many replantation methods to treat scalp avulsion, so the best aesthetic and functional results are achieved. Skin grafting, free flaps, microvascular surgery, and hyperbaric oxygen are all suitable for reconstructive plans. We report a rare case of a scalp avulsion injury in a female due to an entanglement of a headscarf in a motorized machine resulting in defects and tissue loss of the hair‐bearing skin, nasal area, forehead, left ear, and bilateral eyelids and eyebrows. Preoperative management included early blood transfusion, intravenous fluids, and wound compression after rapid physical examination. Reconstructive surgery was performed using a full‐thickness skin graft and the outcomes were pristine. There are no clear guidelines to determine which reconstructive method is superior to another in each condition. Our case demonstrates that relatively primitive methods like skin grafting can give greater results if done with circumspection.
COVID‐19‐associated facial cutaneous mucormycosis superinfection: A potentially life‐threatening disease
Authors: Zareshahrabadi Zahra , Emami Amir , Pakshir Keyvan , Roudgari Amir , Ghaffari Behzad , Rezaei Tahere , Shekarkhar Golsa , Zomorodian Kamiar 
Published: July 2022

AbstractA 49‐year‐old male was involved in an accident and an abdominal computer tomographic examination revealed papillary renal cell carcinoma of the right kidney. During hospitalization, the patient was infected with COVID‐19. In the following COVID‐19 treatment, a black dot developed on the right side of the head and face. Antifungal therapy and surgical debridement were initiated and gradual improvement was observed.
Delayed COVID‐19‐induced cytokine storm after root canal therapy with favorable response to plasmapheresis, tocilizumab, and methylprednisolone pulses therapy: A case report
Authors: Aghaeimeybodi Fatemeh , Derakhshan Barjoei Mohammad Moein , Mohammadi Mohammad , Ghasemirad Hamidreza , Mehrabi Samrad 
Published: July 2022

AbstractCOVID‐19 showed different characteristics, and many cases showed clinical manifestations that could not be attributed to other conditions. We present a 22‐year‐old woman who had an uneventful recovery from COVID‐19, and after that, she developed a cytokine storm and a worsening clinical condition 2 days after dental root canal therapy.
Cardiopulmonary arrest caused by nafamostat mesylate during hemodialysis
Authors: Shioya Nobuki , Inoue Nozomu , Sato Hiroki , Iwahara Motoko , Sato Tomohiro , Tsukamoto Yuki , Naito Yuki , Hazama Kohji , Shichinohe Yasuo 
Published: July 2022

AbstractDialysis‐related adverse reactions can be serious and difficult to predict. In our case, nafamostat mesylate (NM) was thought to be the cause of cardiopulmonary arrest (CPA) due to NM‐induced anaphylaxis but was not reflected in the allergy tests. Rare but life‐threatening drawbacks occur immediately after hemodialysis initiation.
Large, calcified aneurysm of the left ventricle: Case report of an incidental finding
Authors: Georgiev Aleksandar , Tsvetkova Silvia , Goranov Georgi , Nikolov Petar 
Published: July 2022

AbstractThe case is of an 88‐year‐old female patient with an accidental finding of a large, calcified aneurysm near the cardiac apex. Differential diagnoses can be made with false aneurysms and congenital diverticulums. Imaging modalities beneficial for diagnosing LVA are ultrasound, X‐rays, CT, MRI, including PET/CT for oncology patients.
The Role of Hydroxide Binding Energy in Alkaline Hydrogen Oxidation Reaction Kinetics on RuCr Nanosheet†
Authors: Yang Chaoyi , Li Yunbo , Ge Chuangxin , Jiang Wenyong , Cheng Gongzhen , Zhuang Lin , Luo Wei 
Published: July 2022

Comprehensive SummaryUnveiling the role of adsorbed hydroxide involved in the hydrogen oxidation reaction (HOR) under alkaline electrolyte is crucial for the development of advanced HOR electrocatalysts for the alkaline polymer electrolyte fuel cells (APEFCs). Herein, we report the synthesis of amorphous RuCr nanosheets with different molar ratios and their HOR performances under alkaline media. We find a volcano correlation between the Cr content in RuCr nanosheets and their alkaline HOR performance. Experimental results and density functional theory (DFT) calculation reveals that the optimized Cr content in RuCr nanosheets could lead to the optimum hydroxide binding energy (OHBE), contributes to their remarkable alkaline HOR performance with mass activity of 568.1 A·gPGM–1 at 50 mV, 13‐fold higher than that of Ru catalyst. When RuCr nanosheet is further used as the anodic electrocatalyst, a peak power density of 1.04 W·cm–2 can be achieved in an APEFC.
Intracranial hemorrhage subtype classification using learned fully connected separable convolutional network
Authors: Korra Sampath , Mamidi Ravikanth , Soora Narasimha Reddy , Kumar Kotte Vinay , Kumar Naliganti Cornel Santosh 
Published: July 2022

SummaryIn recent decades, intracranial hemorrhage detection from computed tomography (CT) scans has gained considerable attention among researchers in the medical community. The major problem in dealing with the Radiological Society of North America (RSNA) dataset is a three dimensional representation of CT scan, where the labeled data are scarce and hard to obtain. To highlight this problem, a novel learned fully connected separable convolutional network is proposed in this research article. After collecting the CT scans, data augmentation is used to generate multiple image variations to improve the capacity of the proposed model generalization. Based on the albumentations library, the transformations are selected for data augmentation such as brightness adjustment, horizontal flipping, shifting, rotation, and scaling. The intracranial hemorrhage subtype classification is accomplished utilizing a learned fully connected separable convolutional network which significantly classifies six classes as any, intraparenchymal, subarachnoid, epidural, intraventricular, and subdural. In the resulting phase, the learned fully connected separable convolutional network obtained an average accuracy of 98.63%, sensitivity of 73.32%, specificity of 99.49%, and area under the curve of 98.98%, where the obtained results are effective compared with ResNet‐50, SE‐ResNeXt‐50, ResNeXt‐101, and ResNeXt‐101 with bidirectional long short term memory network.
Adaptive regulation based on the spatio‐temporal distribution of ecological flow surplus and deficit in the Hanjiang River basin
Authors: Song Xinxin , Zhuang Yanhua , Li Enhua , Zhang Yingying , Wang Xuelei 
Published: July 2022

AbstractEcological flow has attracted considerable attention because intensive dam construction can cause changes in the hydrological situation and subsequent ecological environment problems. In the Hanjiang River basin, 15 cascade reservoirs are due to become operational in the main stream in the coming years. In this study, the calculation method of ecological flow surplus and deficit was proposed, and the key periods (KPs) and key areas (KAs) of ecological flow deficits were identified. Adaptive regulation strategies were proposed based on a new method. Results show that (1) the wet and normal years are in a state of ecological surplus. In the dry year, there is an ecological flow deficit of 370 million m3. The off‐stream ecological water shortage is at its most serious in June. In the river channel, the ecological flow deficit usually appears in the winter. The Xiantao section in the lower reaches has a deficit every month in the typical water years. (2) In the off‐stream region, the KPs cover months 6 to 9, and the KAs are the southeastern Hanzhong plain, Shiyan City, southeastern Nanyang basin, and the midwest of Xiangyang City. In the river channel, the KPs cover months 12 to 2 above the Shayang section, while in the downstream Xiantao section KA, the KP covers the whole year. The cooperative analysis of KPs and KAs can effectively improve the pertinence of watershed ecological flow regulation. Priority for water resources regulation in water deficient areas should be given to key areas in the key periods.
FishShapes v1: Functionally relevant measurements of teleost shape and size on three dimensions
Authors: Price Samantha A. , Friedman Sarah T. , Corn Katherine A. , Larouche Olivier , Brockelsby Kasey , Lee Anna J. , Nagaraj Maya , Bertrand Nick G. , Danao Mailee , Coyne Megan C. , Estrada John R. , Friedman Rachel , Hoeft Evan , Iwan Mikayla , Gross Dominique , Kao Jo Hsuan , Landry Brian , Linares Monica J. , McGlinn Carley , Nguyen Jennifer A. , Proffitt Allison G. , Rodriguez Sierra , Rupp Maxwell R. , Shen Erin Y. , Susman Victoria , Tovar Angelly J. , Vary Laura L. J. , Zapfe Katerina L. , Wainwright Peter C. 
Published: July 2022

AbstractTeleost fishes account for 96% of all fish species and exhibit a spectacular variety of body forms. Teleost lineages range from deep bodied to elongate (e.g., eels, needlefish), laterally compressed (e.g., ribbonfish) to globular (e.g., pufferfish), and include uniquely shaped lineages such as seahorses, flatfishes, and ocean sunfishes. Adaptive body shape convergence within fishes has long been hypothesized but the nature of the relationships between fish form and ecological and environmental variables remain largely unknown at the macroevolutionary scale. To facilitate the investigation of the interacting factors influencing teleost body shape evolution we measured eight functionally relevant linear traits on adult‐sized specimens along with specimen mass. Linear measurements of standard length, maximum body depth, maximum fish width, lower jaw length, mouth width, head depth, minimum caudal peduncle depth, and minimum caudal peduncle width were taken in millimeters with calipers, or tape measures for oversized specimens. We measured these traits on a total of 16,523 specimens (1–3 specimens per species) at the Smithsonian National Museum of Natural History and took approximately 7000 person hours of data collection to complete. The data went through a three‐step error‐checking process to clean and validate the data and then species averages were calculated. We present the complete specimen data set, which encompasses approximately one‐fifth of extant teleost species diversity, spanning ~90% of teleost families and ~96% of orders. The species and family names are compatible with the taxonomy used by FishBase and the order information with the phylogenetically informed taxonomy of Betancur‐R and colleagues published in 2014. This dataset is licensed under Creative Commons CC0 1.0 Universal (CC0 1.0) but please cite this paper when using the data or a subset of it.
Impact analysis of heart failure across European countries: an ESC‐HFA position paper
Authors: Rosano Giuseppe M.C. , Seferovic Petar , Savarese Gianluigi , Spoletini Ilaria , Lopatin Yuri , Gustafsson Fin , Bayes‐Genis Antoni , Jaarsma Tiny , Abdelhamid Magdy , Miqueo Arantxa Gonzalez , Piepoli Massimo , Tocchetti Carlo G. , Ristić Arsen D. , Jankowska Ewa , Moura Brenda , Hill Loreena , Filippatos Gerasimos , Metra Marco , Milicic Davor , Thum Thomas , Chioncel Ovidiu , Ben Gal Tuvia , Lund Lars H. , Farmakis Dimitrios , Mullens Wilfried , Adamopoulos Stamatis , Bohm Michael , Norhammar Anna , Bollmann Andreas , Banerjee Amitava , Maggioni Aldo P. , Voors Adriaan , Solal Alain Cohen , Coats Andrew J.S. 
Published: July 2022

AbstractHeart failure (HF) is a long‐term clinical syndrome, with increasing prevalence and considerable healthcare costs that are further expected to increase dramatically. Despite significant advances in therapy and prevention, mortality and morbidity remain high and quality of life poor. Epidemiological data, that is, prevalence, incidence, mortality, and morbidity, show geographical variations across the European countries, depending on differences in aetiology, clinical characteristics, and treatment. However, data on the prevalence of the disease are scarce, as are those on quality of life. For these reasons, the ESC‐HFA has developed a position paper to comprehensively assess our understanding of the burden of HF in Europe, in order to guide future policies for this syndrome. This manuscript will discuss the available epidemiological data on HF prevalence, outcomes, and human costs—in terms of quality of life—in European countries.
Impact of ischaemic aetiology on the efficacy of intravenous ferric carboxymaltose in patients with iron deficiency and acute heart failure: insights from the AFFIRM‐AHF trial
Authors: Metra Marco , Jankowska Ewa A. , Pagnesi Matteo , Anker Stefan D. , Butler Javed , Dorigotti Fabio , Fabien Vincent , Filippatos Gerasimos , Kirwan Bridget‐Anne , Macdougall Iain C. , Rosano Giuseppe , Ruschitzka Frank , Tomasoni Daniela , van der Meer Peter , Ponikowski Piotr ,   the AFFIRM‐AHF Investigators
Published: July 2022

AimsIn AFFIRM‐AHF, intravenous ferric carboxymaltose (FCM) reduced heart failure (HF) hospitalisations and improved quality of life versus placebo in iron‐deficient patients stabilised after an acute HF episode. This analysis explored the effects of FCM versus placebo in patients with ischaemic and non‐ischaemic HF aetiology.Methods and resultsWe included 1082 patients from AFFIRM‐AHF: 590 with ischaemic HF (defined as investigator‐reported ischaemic HF aetiology and/or prior acute myocardial infarction and/or prior coronary revascularisation) and 492 with non‐ischaemic HF. The prevalences of male sex, comorbidities, and history of HF were higher in the ischaemic versus non‐ischaemic HF subgroup. Annualised event rates for the primary composite outcome of total HF hospitalisations and cardiovascular death with FCM versus placebo were 65.3 versus 100.6 per 100 patient‐years in the ischaemic HF subgroup (rate ratio [RR] 0.65, 95% confidence interval [CI] 0.47–0.89, p = 0.007) and 58.3 versus 52.5 in the non‐ischaemic HF subgroup (RR 1.11, 95% CI 0.75–1.66, p = 0.60) (pinteraction = 0.039). An interaction between HF aetiology and treatment effect was also observed for the secondary outcome of total HF hospitalisations (pinteraction = 0.038). A nominal increase in quality of life, assessed using the 12‐item Kansas City Cardiomyopathy Questionnaire, was observed with FCM versus placebo, within each subgroup.ConclusionsHeart failure hospitalisations and cardiovascular deaths occurred at a higher rate in patients with ishaemic versus those with non‐ischaemic HF and were reduced by FCM versus placebo only in ischaemic patients. Further studies are needed to assess the role of aetiology in FCM efficacy.
Ecological transition in a World Heritage City: The case of San Cristóbal de La Laguna (Canary Islands)
Authors: Santamarta Juan C. , Cruz‐Pérez Noelia , Rodríguez‐Martín Jesica , Beltrán Rubén Fuentes , de Gracia Mª Dolores Storch , García‐Gil Alejandro 
Published: July 2022

AbstractThe city of La Laguna is one of the largest urban areas of the Canary Islands archipelago, located on the volcanic island of Tenerife (Spain), whose energy demand results in a large carbon footprint due to the typical fossil fuel dependency of oceanic islands. In 2019, La Laguna joined the initiative under the new Climate and Energy Pact and has been working ever since to achieve the EU target of reducing by 55% greenhouse gases emissions by 2030. In this work, we present the results obtained from the study conducted of emissions of the city, focused on buildings, equipment and facilities (1), public lighting (2), transportation (3) and agriculture, forestry and fishing (4) sectors. To this end, emissions in 2009 were studied and compared with those in 2019, resulting in a 4% to 48% carbon dioxide emissions reduction in the last decade. To achieve the goal of reductions of more than 55% by 2030, the city council prepared a Sustainable Energy and Climate Action Plan (SECAP), in which they propose that successfully implemented measures would achieve a 64% reduction in emissions in the municipality.
Age, formation and significance of loess deposits in central Sweden
Authors: Stevens Thomas , Sechi Daniele , Tziavaras Charilaos , Schneider Ramona , Banak Adriano , Andreucci Stefano , Hättestrand Martina , Pascucci Vincenzo 
Published: July 2022

AbstractLoess deposits are common in the mid‐latitudes and are excellent records of past climate, landscape change and dust. However, loess deposits are seldom reported from Fennoscandia. Here we investigate two former glaciofluvial areas in central Sweden, Brattforsheden and Bonäsheden, where post‐glacial loess and sand dune activity have been documented previously. Based on detailed mapping, grain size, scanning electron microscopy and optically stimulated luminescence dating analyses, we confirm the presence of loess deposits at the sites and extend the known area of loess coverage. Our results suggest that loess deposits are more common than previously thought in Sweden. The results also demonstrate that basal parts of the loess are often mixed with underlying sediment, which may be a common feature of thin loess deposits close to former ice margins. Quartz luminescence is well suited for dating these deposits, but ages from the mixed basal loess layers are older than expected, while ages from undisturbed loess extend to c. 5 ka. The loess ages contrast with the timing of main dune activity in these areas, which is dominantly in the 1–3 kyr post‐deglaciation (c. 10.9–10.5 cal kyr BP). We suggest that either sediment mixing during soil formation is responsible for the mid‐Holocene loess ages, or that the loess deposits record periodic landscape destabilization into the mid‐Holocene. Furthermore, there is a clear topographic control on aeolian sedimentary facies, with loess mantling high ground and dunes restricted to valleys. Loess deposits are also primarily found to the south and southwest of source areas, implying transport from the north and east. This pattern contrasts with evidence for NW winds inferred from associated sand dunes. At present, the reasons for this mismatch are unclear, although one possible explanation is that silts deposited at higher elevations were affected by Ekman flow deflection of NW surface winds.