bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individual differences in naturally occurring affect predict conceptual breadth: evidence for the importance of arousal by valence interactions
Authors: Chung Andrew , Busseri Michael A. , Arnell Karen M. 
Published: November 2022

AbstractSeveral studies have investigated the effect of induced mood state on conceptual breadth (breadth and flexibility of thought). Early studies concluded that inducing a positive mood state broadened cognition, while inducing a negative mood state narrowed cognition. However, recent reports have suggested that valence and arousal can each influence conceptual breadth. Individual differences in affective dispositions may bias perceptions, thoughts, and behaviors and, in turn, may be biased by them. Here, we examine whether individual differences in valence and arousal dimensions of self-reported, naturally occurring affect relate to conceptual breadth (using the Remote Associates Test, the Object Categorization Task, and the Alternative Uses Task), with no mood manipulations or cues. The three conceptual breadth tasks loaded onto a latent conceptual breadth factor that was predicted significantly by the interaction of valence and arousal. For participants low in arousal, greater positive affect was associated with greater conceptual breadth. For participants high in arousal, greater positive affect was associated with reduced conceptual breadth. In contrast to most existing theories of conceptual breadth that highlight the importance of valence or arousal alone, the present results suggest that the interaction between arousal and valence is key to predicting individual differences in conceptual breadth. We posit that positive mood states predict greater conceptual breadth in the presence of low versus high arousal due to a relaxation of cognitive control under low arousal.
The impact of location tax incentives on the growth of rural economy: evidence from Ghana
Authors: Amankwaah Eric , Mensah Nicholas , Baidoo Nana Okyir 
Published: November 2022

AbstractOver the last two decades, location tax incentives programs serving as a motivating force have been progressively well known as activities to draw in and/or hold foreign direct investments (FDIs) in economically blighted areas. The study examined the impact of location tax incentives on the growth of the rural economy of Ghana from the period of 1994 to 2018. The data were sourced from Ghana Investment Promotion, UNCTAD, and the World Tax Database. Using ARDL Cointegration and Error Correction Models were estimated to examine the static and dynamic long-run effects as well as the short-run dynamics of the system and the speed of adjustment to the long-run equilibrium. However, FDI is skewed towards the Greater Accra region, Ashanti region, Central region, and Eastern and Western regions notwithstanding the location tax incentives the government has been given since the 1990s. The study shows that there is a positive and statistically significant effect of tax incentives on employment creation and rural development in the long run. It revealed that trade openness and market size have a significant effect on employment creation and rural development. It emerged that there is no correlation between location tax incentives and the regional distribution of FDI in Ghana. It has become a well-established fact that adequate tax holidays are beneficial to businesses and encourage them to make investment decisions. It is therefore recommended that a more extensive mindfulness crusade through workshops, courses, and advertisements is necessary to empower the investors about the accessible business opportunities.
High intelligence is not associated with a greater propensity for mental health disorders
Authors: Williams Camille Michèle , Peyre Hugo , Labouret Ghislaine , Fassaya Judicael , Guzmán García Adoración , Gauvrit Nicolas , Ramus Franck 
Published: November 2022

Abstract

Background
Studies reporting that highly intelligent individuals have more mental health disorders often have sampling bias, no or inadequate control groups, or insufficient sample size. We addressed these caveats by examining the difference in the prevalence of mental health disorders between individuals with high and average general intelligence (g-factor) in the UK Biobank.

Methods
Participants with g-factor scores standardized relative to the same-age UK population, were divided into two groups: a high g-factor group (g-factor 2 SD above the UK mean; N = 16,137) and an average g-factor group (g-factor within 2 SD of the UK mean; N = 236,273). Using self-report questionnaires and medical diagnoses, we examined group differences in the prevalence of 32 phenotypes, including mental health disorders, trauma, allergies, and other traits.

Results
High and average g-factor groups differed across 15/32 phenotypes and did not depend on sex and/or age. Individuals with high g-factors had less general anxiety (odds ratio [OR] = 0.69, 95% CI [0.64;0.74]) and post-traumatic stress disorder (PTSD; OR = 0.67, 95 %CI [0.61;0.74]), were less neurotic (β = −0.12, 95% CI [−0.15;−0.10]), less socially isolated (OR = 0.85, 95% CI [0.80;0.90]), and were less likely to have experienced childhood stressors and abuse, adulthood stressors, or catastrophic trauma (OR = 0.69–0.90). However, they generally had more allergies (e.g., eczema; OR = 1.13–1.33).

Conclusions
The present study provides robust evidence that highly intelligent individuals do not have more mental health disorders than the average population. High intelligence even appears as a protective factor for general anxiety and PTSD.
Directionality between driven-dissipative resonators
Authors: Downing C. A. , Sturges T. J. 
Published: November 2022

Abstract
The notion of nonreciprocity, in essence when going forwards is different from going backwards, emerges in all branches of physics from cosmology to electromagnetism. Intriguingly, the breakdown of reciprocity is typically associated with extraordinary phenomena, which may be readily capitalized on in the design of (for example) nontrivial electromagnetic devices when Lorentz reciprocity is broken. However, in order to enable the exploitation of nonreciprocal-like effects in the next generation of quantum technologies, basic quantum optical theories are required. Here we present a versatile model describing a pair of driven-dissipative quantum resonators, where the relative phase difference between the coherent and incoherent couplings induces an asymmetry. The interplay between the diverse dissipative landscape —which encompasses both intrinsic losses and dissipative couplings— and the coherent interactions leads to some remarkable consequences including highly directional (or even one-way) energy transport. Our work proffers the tantalizing prospect of observing dissipation-induced quantum directionality in areas like photonics or cavity magnonics (spin waves), which may aid the design of unconventional nanoscopic devices.
Ferroelectric and antiferroelectric distortions coupling of nitride perovskite LaWN3 under epitaxial strain using first-principles calculations
Authors: Wang Xiangjian , Zhu Linguang , Geng Wenping , Lou Xiaojie 
Published: November 2022

Abstract
LaWN3, a novel nitride perovskite, have been synthesized and its piezoelectric properties have been investigated (Talley K. R. et al., Science, 374 (2021) 1488). However, the understanding of its ferroelectric properties under the external strain is still lacking. Here, the misfit-strain–dependent coupling between antiferrodistortions (AFD) and ferroelectric (FE) distortions has been studied by using a first-principle approach. It can be observed that AFD and FE distortions can work cooperatively with each other as the compressive strain increases, and the coupling energy between them is found to work in different ways under various strains. Our results show that the coupling tends to stabilize the ground structure when the compressive strain is smaller than −1.9%, it works oppositely when the compressive strain becomes larger than 1.9%. Our results can provide us with more hints about the influence of the epitaxial strains on the intrinsic coupling behavior in the perovskite ferroelectric compounds, which is very important for us to design and fabricate new kinds of functional materials.
Patient Safety Indicator 04 Does Not Consistently Identify Failure to Rescue in the Neurosurgical Population
Authors: Azad Tej D. , Rodriguez Emily , Raj Divyaansh , Xia Yuanxuan , Materi Joshua , Rincon-Torroella Jordina , Gonzalez L. Fernando , Suarez Jose I. , Tamargo Rafael J. , Brem Henry , Haut Elliott R. , Bettegowda Chetan 
Published: November 2022

BACKGROUND:
Improving neurosurgical quality metrics necessitates the analysis of patient safety indicator (PSI) 04, a measure of failure to rescue (FTR).

OBJECTIVE:
To demonstrate that PSI 04 is not an appropriate measure for capturing FTR within neurosurgery.

METHODS:
We conducted a single-center retrospective cohort study. Patients from January 1, 2017 to June 1, 2021, who sustained a PSI 04-attributed complication (pneumonia, deep vein thrombosis/pulmonary embolism, sepsis, shock/cardiac arrest, or gastrointestinal hemorrhage/acute ulcer), underwent a neurosurgical procedure, had inpatient mortality, and were identified using patient safety indicator 04 (PSI 04) tracking algorithm. The primary outcome was whether the attributed PSI 04 designation was the primary driver of mortality.

RESULTS:
We identified 67 patients who met the PSI 04 criteria (median age, 61 years; female sex, 43.4%). Nearly 20% of patients met the PSI complication criteria before admission. Patients who underwent emergent bedside procedures were more likely to present with a poor Glasgow Coma Scale (P = .016), more likely to be intubated before admission (P = .016), and less likely to have mortality due to a PSI 04-related complication (P = .002). PSI 04-related complications were identified as the cause of death in only 43.2% of cases. Procedures occurring in the interventional radiology suite (odds ratio, 23.2; 95% CI, 3.5-229.3; P = .003) or the operating room (odds ratio, 6.2; 95% CI, 1.25-39.5; P = .03) were more likely to have mortality because of a PSI 04-related complication compared with bedside procedures.

CONCLUSION:
In total, 65.7% of patients were inappropriately flagged as meeting PSI 04 criteria. PSI 04 currently identifies patients with complications unrelated to operating room procedures. Improvement in patient safety within neurosurgery necessitates the development of a subspecialty specific measure to capture FTR.
Illuminati: a form of gene expression plasticity in Drosophila neural stem cells
Authors: Goupil Alix , Heinen Jan Peter , Salame Riham , Rossi Fabrizio , Reina Jose , Pennetier Carole , Simon Anthony , Skorski Patricia , Louzao Anxela , Bardin Allison J. , Basto Renata , Gonzalez Cayetano 
Published: November 2022

ABSTRACT
While testing for genome instability in Drosophila as reported by unscheduled upregulation of UAS-GFP in cells that co-express GAL80 and GAL4, we noticed that, as expected, background levels were low in most developing tissues. However, GFP-positive clones were frequent in the larval brain. Most of these clones originated from central brain neural stem cells. Using imaging-based approaches and genome sequencing, we show that these unscheduled clones do not result from chromosome loss or mutations in GAL80. We have named this phenomenon ‘Illuminati’. Illuminati is strongly enhanced in brat tumors and is also sensitive to environmental conditions such as food content and temperature. Illuminati is suppressed by Su(var)2-10, but it is not significantly affected by several modifiers of position effect variegation or Gal4::UAS variegation. We conclude that Illuminati identifies a previously unknown type of functional instability that may have important implications in development and disease.
Single-cell RNA-sequencing analysis of early sea star development
Authors: Foster Stephany , Oulhen Nathalie , Fresques Tara , Zaki Hossam , Wessel Gary 
Published: November 2022

ABSTRACT
Echinoderms represent a broad phylum with many tractable features to test evolutionary changes and constraints. Here, we present a single-cell RNA-sequencing analysis of early development in the sea star Patiria miniata, to complement the recent analysis of two sea urchin species. We identified 20 cell states across six developmental stages from 8 hpf to mid-gastrula stage, using the analysis of 25,703 cells. The clusters were assigned cell states based on known marker gene expression and by in situ RNA hybridization. We found that early (morula, 8-14 hpf) and late (blastula-to-mid-gastrula) cell states are transcriptionally distinct. Cells surrounding the blastopore undergo rapid cell state changes that include endomesoderm diversification. Of particular import to understanding germ cell specification is that we never see Nodal pathway members within Nanos/Vasa-positive cells in the region known to give rise to the primordial germ cells (PGCs). The results from this work contrast the results of PGC specification in the sea urchin, and the dataset presented here enables deeper comparative studies in tractable developmental models for testing a variety of developmental mechanisms.
Longitudinal in vivo imaging of adult Danionella cerebrum using standard confocal microscopy
Authors: Lam Pui-Ying 
Published: November 2022

ABSTRACT
Danionella cerebrum is a new vertebrate model that offers an exciting opportunity to visualize dynamic biological processes in intact adult animals. Key advantages of this model include its small size, life-long optical transparency, genetic amenability and short generation time. Establishing a reliable method for longitudinal in vivo imaging of adult D. cerebrum while maintaining viability will allow in-depth image-based studies of various processes involved in development, disease onset and progression, wound healing, and aging in an intact live animal. Here, a method for both prolonged and longitudinal confocal live imaging of adult D. cerebrum using custom-designed and 3D-printed imaging chambers is described. Two transgenic D. cerebrum lines were created to test the imaging system, i.e. Tg(mpeg1:dendra2) and Tg(kdrl:mCherry-caax). The first line was used to visualize macrophages and microglia, and the second for spatial registration. By using this approach, differences in immune cell morphology and behavior during homeostasis as well as in response to a stab wound or two-photon-induced brain injury were observed in intact adult fish over the course of several days.
RAS Mutation Status Should Not Be Used to Predict Outcome from Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Colorectal Peritoneal Metastases
Authors: Bhullar Dilraj , O’Dwyer Sarah , Wilson Malcolm , Saunders Mark P. , Kochhar Rohit , Barriuso Jorge , Aziz Omer 
Published: November 2022

Abstract
Background
Genetic biomarkers guide systemic anti-cancer treatment (SACT) in metastatic colorectal cancer. It has been suggested they have a role in selecting patients with colorectal peritoneal metastases (CRPM) for cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). This study aims to quantify the effect of mutation status on overall survival (OS), adjusting for confounders such as pre-operative systemic anticancer treatment (SACT).

Patients and Methods
Retrospective analysis of patients undergoing CRS/HIPEC for CRPM at a national peritoneal tumour centre (2004–2017) was performed. Demographics, treatment history and operative data were extracted. Known biomarker gene mutation status was noted including: KRAS, NRAS, BRAF, PIK3CA and MMR. Cox regression analysis and Kaplan–Meier curves were used to determine overall survival.

Results
One hundred ninety-five patients were included. Median follow-up time was 34.7 months (range 5.4–184.9 months) and median OS was 38.7 months (95% CI 32.4–44.9 months). Biomarker status was as follows: KRAS (n = 114), NRAS (n = 85), BRAF (n = 44), PIK3CA (n = 15) and MMR (n = 21). Mutation rates were 45.6%, 3.5%, 13.6%, 13.3% and 14.3%, respectively. Seventy-four per cent underwent complete cytoreduction (CC = 0), 81% received SACT pre-CRS/HIPEC and 65% post-CRS/HIPEC. RAS (p = 0.21) or BRAF (p = 0.109) mutation status did not predict OS. Nodal involvement, extramural vascular invasion, Peritoneal Cancer Index (PCI) score, CC score, SACT post-HIPEC and NRAS mutation were significant negative predictors of OS in univariate analysis (p < 0.05). Multivariate Cox regression confirmed CC-score > 1 (HR: 7.599, 95% CI 3.402–16.974, p < 0.0001) as a negative predictor of OS. RAS mutation status did not affect outcome (HR: 1.682, 95% CI 0.995–2.843, p = 0.052).

Conclusions
RAS mutation status should not in isolation be used to select patients for CRS/HIPEC.
Formation of a Tight Complex between Amphidinol 3 and Sterols in Lipid Bilayers Revealed by Short-Range Energy Transfer
Authors: Hieda Manami , Tsujimura Koya , Kinoshita Masanao , Matsumori Nobuaki 
Published: November 2022

Abstract
The exploration of molecular recognition in lipid bilayers is still extremely difficult. In this report, we leveraged short-range energy transfer (ET) that enabled detection of close contacts within 1 nm distance, and applied it to the interaction of natural products with sterols in lipid bilayers. Amphidinol 3 (AM3), a polyhydroxy–polyene metabolite from a marine dinoflagellate, possesses potent antifungal activity by forming membrane pores in a sterol-dependent manner. Although AM3 was shown to interact directly with membrane sterols, the mode of interaction is yet to be fully elucidated. Herein, we found that AM3 and cholestatrienol (CTL), a fluorescent sterol, can be an ET pair because the emission spectrum of the former overlaps with the excitation of the latter. We further confirmed that CTL exerts the sterol-dependent pore formation of AM3 as in the case of cholesterol. Then, titration using intermolecular ET in bilayers revealed that AM3 and CTL form a 1:1 complex with a dissociation constant of 1.4 × 10−5 M. The distance between the AM3 polyene and CTL triene was estimated to be less than 1 nm. Based on this information, we proposed a tight binding model between AM3 and the sterol in lipid bilayers.
Stage 1 Registered Report: Refinement of tickling protocols to improve positive animal welfare in laboratory rats
Authors: Bombail Vincent , Brown Sarah M. , Martin Jessica E. , Meddle Simone L. , Mendl Michael , Robinson Emma S.J. , Hammond Tayla J. , Nielsen Birte L. , LaFollette Megan R. , Vinuela-Fernandez Ignacio , Tivey Emma K.L. , Lawrence Alistair B. 
Published: November 2022

Rat tickling is a heterospecific interaction for experimenters to mimic the interactions of rat play, where they produce 50 kHz ultrasonic vocalisations (USV), symptoms of positive affect; tickling can improve laboratory rat welfare. The standard rat tickling protocol involves gently pinning the rat in a supine position. However, individual response to this protocol varies. This suggests there is a risk that some rats may perceive tickling as only a neutral experience, while others as a positive one, depending on how tickling is performed. Based on our research experiences of the standard tickling protocol we have developed a playful handling (PH) protocol, with reduced emphasis on pinning, intended to mimic more closely the dynamic nature of play. We will test whether our PH protocol gives rise to more uniform increases in positive affect across individuals relative to protocols involving pinning. We will compare the response of juvenile male and female Wistar rats as: Control (hand remains still against the side of the test arena), P0 (PH with no pinning), P1 (PH with one pin), P4 (PH with four pins). P1 and P4 consist of a background of PH, with treatments involving administration of an increasing dosage of pinning per PH session. We hypothesise that rats exposed to handling protocols that maximise playful interactions (where pinning number per session decreases) will show an overall increase in total 50 kHz USV as an indicator of positive affect, with less variability. We will explore whether behavioural and physiological changes associated with alterations in PH experience are less variable. We propose that maximising the numbers of rats experiencing tickling as a positive experience will reduce the variation in response variables affected by tickling and increase the repeatability of research where tickling is applied either as a social enrichment or as a treatment.
Bioactivity and metabolite profile of papaya (Carica papaya) seed extract
Authors: ALFARABI MUHAMMAD , SIAGIAN FORMAN ERWIN , CING JAP MAI , SURYOWATI TRINI , TURHADI TURHADI , SUYONO MICHELTHELIA SULIJAYA , FEBRIYANTI MONICA SYEFI , NAIBAHO FITRI BORU 
Published: November 2022

Abstract. Alfarabi M, Siagian FE, Cing JM, Suryowati T, Turhadi, Suyono MS, Febriyamti MS, Naibaho FB. 2022. Bioactivity and metabolite profile of papaya (Carica papaya) seed extract. Biodiversitas 23: 4589-4600. Papaya (Carica papaya) seeds are part of the papaya plant which is a source of organic waste. However, there are many scientific studies thatstate the metabolites found in papaya seeds have various benefits in medical aspects. Accordingly, the objective of this study was to examine the antioxidant and cytotoxic activity of California and Bangkok type papaya seeds which are two local papaya types and widely consumed by the people of Indonesia. These papaya seeds'metabolite profiling was also conducted in this study therefore the antioxidant activity and cytotoxic mechanisms can be estimated. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) method is used to investigate the antioxidant activity while 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) isused to investigate the cytotoxic effect of extract. Metabolites contained in papaya seeds were measured by Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid Chromatography-Mass Spectrometry-QTOF (LC-MS/MS-QTOF). The results showed that California and Bangkok papaya seed extracts had antioxidant activity with IC50being 24.4 ppm and 22.2 ppm, respectively. Both extracts were also able to inhibit the growth of cancer cells (MCF-7) and did not render any toxic effects on non-cancer cells at low concentrations. The metabolites contained in the two extracts were alkaloid, phenol hydrocarbon, flavonoid, fatty acid, and terpenoid groups. This study showed that papaya seeds have the potential to be further developed in medical field, especially as natural antioxidants and natural cancer-preventing ingredients.