bluuebunny/crossref_metadata_2025_split huggingface dataset:
The long-term effect of job mobility on workers’ mental health: a propensity score analysis
Authors: Maniscalco Laura , Schouteden Martijn , Boon Jan , Vandenbroeck Sofie , Mehlum Ingrid Sivesind , Godderis Lode , Matranga Domenica 
Published: June 2022

Abstract
Objectives
The main purpose of this longitudinal study was to elucidate the impact of external job mobility, due to a change of employer, on mental health.

Methods
A cohort of Belgian employees from the IDEWE occupational medicine registry was followed-up for twenty-seven years, from 1993 to 2019. The use of drugs for neuropsychological diseases was considered as an objective indicator of mental health. The covariates were related to demographic, physical, behavioural characteristics, occupational and work-related risks. Propensity scores were calculated with a Cox regression model with time-varying covariates. The PS matching was used to eliminate the systematic differences in subjects’ characteristics and to balance the covariates’ distribution at every time point.

Results
The unmatched sample included 11,246 subjects, with 368 (3.3%) that changed their job during the baseline year and 922 (8.2%) workers that left their employer during the follow-up. More than half of the matched sample were males, were aged less than 38 years old, did not smoke, were physically active, and normal weighted, were not exposed to shift-work, noise, job strain or physical load. A strong association between job mobility and neuropsychological treatment was found in the matched analysis (HR = 2.065, 95%CI = 1.397–3.052, P-value < 0.001) and confirmed in the sensitivity analysis (HR of 2.012, 95%CI = 1.359–2.979, P-value < 0.001). Furthermore, it was found a protective role of physical activity and a harmful role of job strain on neuropsychological treatment.

Conclusions
Our study found that workers with external job mobility have a doubled risk of treatment with neuropsychological medication, compared to workers without job mobility.
Scope of Iranian community health nurses ‘services from the viewpoint of the managers and nurses: a content analysis study
Authors: Hosseinnejad Aazam , Rassouli Maryam , Jahani Simin , Elahi Nasrin , Molavynejad Shahram 
Published: June 2022

AbstractBackgroundConsidering the need for nurses specializing in community health and in order to define professional duties for future planning towards creating the position of community health nurses in the primary health care system of Iran, this study aims to explain the range of services which can be provided by community health nurses from the perspective of the mangers and nurses.MethodsThe present qualitative study was conducted with the approach of contract content analysis in Iran in 2020. This study was conducted through in-depth and semi-structured interviews with 22 participants, including community health nursing faculty members, health deputies and managers, community health nurses working in health centers, and the care seekers visiting comprehensive health centers. The samples were selected through purposeful sampling. The interviews continued until data saturation. Data analysis was performed simultaneously with data collection. The interviews were recorded, transcribed, and analyzed through Graneheim & Lundman’s content analysis method, and data management was done using MAXQDA software. To achieve data trustworthiness, the criteria presented by Lincoln and Guba were used.ResultsThe obtained data were classified into the two main categories of service provision settings and service provision domains. The category service provision settings covered 7 subcategories including participation in the family physician plan, activities at the centers for vulnerable groups of the community, establishing private community health clinics, leading health promotion programs in the 3rd generation hospitals, activities in comprehensive health centers, follow-ups and home visits, and activities in schools’ health units. Service provision domains consisted of 6 subcategories including participation in health planning, decision-making, and policymaking, research on the health system, health promotion, monitoring and coordination, providing care for the patients with non-communicable diseases and high-risk groups, and eldercare.ConclusionsFrom the participants’ perspective, important services that can be provided by the community health nurse are health promotion, the management of chronic patients and the elderly, follow-ups, and home visits. Therefore, it is recommended that health policy makers pay attention to the service provision areas and the services providable by the community health nurse in their macro-planning, and to provide primary health care in comprehensive health centers using inter-professional care models, integrating the community health nurse into the care team.
Transcriptomic analysis reveals pathophysiological relationship between chronic obstructive pulmonary disease (COPD) and periodontitis
Authors: Liu Shuqin , Fu Yun , Ziebolz Dirk , Li Simin , Schmalz Gerhard , Li Fan 
Published: June 2022

AbstractBackgroundThe aim of this study was to detect potential crosstalk genes, pathways and immune cells between periodontitis and chronic obstructive pulmonary disease (COPD).MethodsChronic periodontitis (CP, GSE156993) and COPD (GSE42057, GSE94916) datasets were downloaded. Differential expressed genes (DEGs;p < 0.05) were assessed and screened for overlapping results, following functional pathway enrichment analyses (p < 0.05). The xCell method was used to assess immune cell infiltration relationship between CP and COPD. Features of the detected cross-talk genes were revealed using conventional Recursive Feature Elimination (RFE) algorithm in R project. Receiver-operating characteristic curves were applied to evaluate the predictive value of the genes. Furthermore, Pearson correlation analysis was performed on crosstalk markers and infiltrating immune cells in CP and COPD, respectively.ResultsA total of 904 DEGs of COPD and 763 DEGs of CP were acquired, showing 22 overlapping DEGs between the two diseases. Thereby 825 nodes and 923 edges were found in the related protein–protein-interaction network. Eight immune cell pairs were found to be highly correlated to both CP and COPD (|correlation coefficients |> 0.5 andp-value < 0.05). Most immune cells were differently expressed between COPD and CP. RFE identified three crosstalk genes, i.e. EPB41L4A-AS1, INSR and R3HDM1. In correlation analysis, INSR was positively correlated with Hepatocytes in CP (r = 0.6714,p = 0.01679) and COPD (r = 0.5209,p < 0.001). R3HDM was positively correlated with Th1 cells in CP (r = 0.6783,p = 0.0153) and COPD (r = 0.4120,p < 0.01).ConclusionEPB41L4A-AS1, INSR and R3HDM1 are potential crosstalk genes between COPD and periodontitis. R3HDM was positively correlated with Th1 cells in both diseases, while INSR was positively correlated with Hepatocytes in periodontitis and COPD, supporting a potential pathophysiological relationship between periodontitis and COPD.
Emerging roles for lncRNA-NEAT1 in colorectal cancer
Authors: Azizidoost Shirin , Ghaedrahmati Farhoodeh , Anbiyaee Omid , Ahmad Ali Riyadh , Cheraghzadeh Maryam , Farzaneh Maryam 
Published: June 2022

AbstractColorectal cancer (CRC) is the third cause of cancer death in the world that arises from the glandular and epithelial cells of the large intestine, during a series of genetic or epigenetic alternations. Recently, long non-coding RNAs (lncRNAs) has opened a separate window of research in molecular and translational medicine. Emerging evidence has supported that lncRNAs can regulate cell cycle of CRC cells. LncRNA NEAT1 has been verified to participate in colon cancer development and progression. NEAT1 as a competing endogenous RNA could suppress the expression of miRNAs, and then regulate molecules downstream of these miRNAs. In this review, we summarized emerging roles of NEAT1 in CRC cells.
Expert views on state-level naloxone access laws: a qualitative analysis of an online modified-Delphi process
Authors: Grant Sean , Smart Rosanna 
Published: June 2022

Abstract
Background
Expanding availability to naloxone is a core harm reduction strategy in efforts to address the opioid epidemic. In the US, state-level legislation is a prominent mechanism to expand naloxone availability through various venues, such as community pharmacies. This qualitative study aimed to identify and summarize the views of experts on state-level naloxone access laws.

Methods
We conducted a three-round modified-Delphi process using the online ExpertLens platform. Participants included 46 key stakeholders representing various groups (advocates, healthcare providers, human/social service practitioners, policymakers, and researchers) with expertise naloxone access laws. Participants commented on the effectiveness and implementability of 15 state-level naloxone access laws (NALs). We thematically analyzed participant comments to summarize views on NALs overall and specific types of NAL.

Results
Participants commented that the effectiveness of NALs in reducing opioid-related mortality depends on their ability to make sustained, significant impacts on population-level naloxone availability. Participants generally believed that increased naloxone availability does not have appreciable negative impacts on the prevalence of opioid misuse, opioid use disorder (OUD), and non-fatal opioid overdoses. Implementation barriers include stigma among the general public, affordability of naloxone, and reliance on an inequitable healthcare system.

Conclusions
Experts believe NALs that significantly increase naloxone access are associated with less overdose mortality without risking substantial unintended public health outcomes. To maximize impacts, high-value NALs should explicitly counter existing healthcare system inequities, address stigmatization of opioid use and naloxone, maintain reasonable prices for purchasing naloxone, and target settings beyond community pharmacies to distribute naloxone.
Extramedullary hematopoiesis in an inguinal lymph node: an unusual presentation of primary myelofibrosis
Authors: Yaqoob Nausheen , Mansoor Neelum , Naveed Hania , Jamal Saba 
Published: June 2022

Abstract
Background
Extramedullary hematopoiesis (EMH) is a proliferation of hematopoietic tissue outside of the bone marrow medullary space. It is a pathophysiologic response, more often associated with either a benign reactive hematological disease or a myeloproliferative neoplasm (MPN). Identification of EMH in adults is always pathologic. It is highly unlikely for a myeloproliferative neoplasm to present with inguinal lymphadenopathy. An unusual and complex case can be precisely diagnosed via a multidisciplinary approach involving experts from various modalities of laboratory. In this regard, the present case highlights the importance of an integrated approach in establishing the diagnosis.

Case presentation
We report a case of a 61-year-old male patient of primary myelofibrosis who presented with extramedullary hematopoiesis in an inguinal lymph node. The patient initially presented with generalized symptoms including anemia, fatigue, abdominal pain, and weight loss. On examination, massive splenomegaly. Chest X-ray revealed consolidation which was secondary to right-sided pleural effusion. Therefore, he was suspected to have a lung carcinoma. However, lymph node biopsy revealed extensive fibrosis, consequently effacing the nodal architecture. An abnormal blood picture raised the possibility of bone marrow infiltration. Extensive panel of markers is tested on lymph node and bone trephine. Cytogenetic studies with G-banding analysis and fluorescence in situ hybridization (FISH) played a significant role in deriving clinical decision. Translocations identified in conventional cytogenetic workup led to the diagnosis of primary myelofibrosis. The case is being reported due to unusual presentation of PMF.

Conclusion
In conclusion, it is a distinctive case of myeloproliferative disorder initially presented with extramedullary hematopoiesis and through multidisciplinary workup successfully diagnosed as primary myelofibrosis. Awareness of unique clinical presentations and integrated approach towards diagnosis is the key to such challenging cases.
Future destinations and social inclusion scoping review: how people cured of hepatitis C (HCV) using direct- acting antiviral drugs progress in a new HCV-free world
Authors: Donaldson Sarah R. , Radley Andrew , Dillon John F. 
Published: June 2022

Abstract
Background
There has been a paradigm shift in the treatment of Hepatitis C (HCV) from the interferon-era to direct-acting antiviral (DAA) drugs. Cure of HCV for the key risk group, those with a history of injecting drug use, may provide a range of benefits to an individual’s quality of life that can be additional to that of a clinical cure. The interferon-era provided evidence that cure of HCV can be a turning point for those who use drugs, supporting a recovery journey. There remains a question if DAAs can provide the same opportunity.

Methods
We employed a scoping review methodology to consider the additional non-clinical benefits that HCV cure may provide. We used the theoretical construct of recovery capital to consider how these benefits may support a recovery journey in the DAA-era.

Results
Our search provided 2095 articles, from which 35 were included in the analysis. We developed a thematic synthesis of the non-clinical outcomes identified based on the four over-arching themes of recovery capital: physical, cultural, social and human capital. Our review suggests that identity change is a constituent part of each of the recovery capital domains in relation to HCV treatment.

Conclusion
We identified Social Identity Model Of Recovery (SIMOR) as a mechanism through which DAAs may provide non-clinical outcomes to increase recovery capital domains. Further research is required to develop an understanding of the impact a cure of HCV with DAAs may have on identity, overall health and wellbeing and social inclusion to support recovery journeys.
Acute benign pleural effusion, a rare presentation of hepatitis A virus: a case report and review of the literature
Authors: Zalloum Jihad Samer , Alzughayyar Tareq Z. , Abunejma Fawzy M. , Mayadma Ibba , Tomeh Layan Ziad , Abulaila Karim Jamal , Yagmour Asil Husam , Faris Khalid Jamal , Aramin Mohammed A. S. , Mesk Mo’min Ra’id , Hasani Asala Khalil , Shawer Balqis Mustafa , Titi Rawand Hisham , Aljuba Ayat A. Z. , Alzeerelhouseini Hussam I. A. , Zatari Yousef I. M. 
Published: June 2022

Abstract
Introduction
Hepatitis A virus infections are mostly asymptomatic or mildly symptomatic, and generally this disease has a benign course and resolves spontaneously. However, intrahepatic and rarer extrahepatic manifestations can complicate typical cases of acute hepatitis. Pleural effusion is an extremely rare extrahepatic entity with 20 cases reported in literature.

Case presentation
We report herein a recent case of both pleural effusion and ascites accompanying hepatitis A infection in a 5-year-old middle eastern child, diagnosed using serological testing and imaging studies, who was treated with supportive management with full resolution after 2 weeks. In addition, we review available literature regarding hepatitis A virus associated with pleural effusion using PubMed and summarize all reported cases in a comprehensive table.

Results
Literature contains 20 reported cases of serology-confirmed hepatitis A virus presenting with pleural effusion, most in the pediatric population with average age at presentation of 9 years 8 months. The majority of reported patients had right-sided pleural effusion (50%) or bilateral effusion (45%), while only 5% presented with pleural effusion on the left side. Hepatomegaly and ascites occurred concurrently in 80% and 70% respectively. Supportive treatment without invasive procedures (except one chylothorax case) yielded complete recovery in 95% of cases, while only one case progressed to fulminant liver failure followed by death.

Conclusion
Acute hepatitis A virus rarely presents with pleural effusion, usually following a benign course with spontaneous resolution in most patients. Pleural effusion does not change the prognosis or require any invasive treatment. Thus, further invasive procedures are not recommended and would only complicate this self-resolving benign condition.
Artificial weathering of rock types bearing petroglyphs from Murujuga, Western Australia
Authors: Neumann Jolam T. , Black John L. , Hœrlé Stéphane , Smith Benjamin W. , Watkins Ron , Lagos Markus , Ziegler Alexander , Geisler Thorsten 
Published: June 2022

Abstract
Murujuga in Western Australia has the largest concentration of ancient rock engravings (petroglyphs) in the world. However, the Murujuga rock art is potentially threatened by local industrial air pollution, in particular by acid rain, but unambiguous scientific evidence is still missing. Here, we report on results of an accelerated weathering experiment, simulating Murujuga weather and climate conditions that was designed and performed to test whether the expected small changes in chemical, mineralogical, and physical characteristics of the rock surface can be detected and reliably quantified by various analytical means. Locally acquired Murujuga granophyre and gabbro samples with natural varnish were artificially weathered for up to four months in a climate chamber under conditions that simulated 2 years of natural weathering. Mineralogical, chemical, and physical changes were qualitatively monitored by X-ray diffraction and confocal Raman spectroscopy, and quantified by colorimetry, portable X-ray fluorescence spectrometry, and micro-computed tomography. In addition, artificial rainwater that was sprinkled over the rock samples was collected and analysed by inductively-coupled plasma mass spectrometry. The results show significant chemical and physical changes of the surfaces of the rock varnish after 1 month of artificial weathering. The analytical results demonstrate that it is possible to quantitatively monitor small changes caused by the weathering of gabbro and granophyre. Therefore, such a semi-actualistic experimental approach, when carefully designed, potentially allows testing the hypothesis that the weathering rate of the Murujuga petroglyphs is increased by local industrial air pollution. Further experimental work is currently under way.
Exploring the applicability of virtual reality- enhanced education on extrovert and introvert EFL learners’ paragraph writing
Authors: Khodabandeh Farzaneh 
Published: June 2022

AbstractDuring the past decade, Virtual reality (VR)-enhanced education has been adopted as a pedagogically new learning approach to smooth the learning progress. With the rise of VR-enhanced activities, investigating the effect of personality types of EFL learners on their writing performance to use VR-based instruction for learning may be a crucial factor influencing their achievement. This study was an attempt to research the impact of VR- enhanced classes on paragraph writing of extrovert and introvert English foreign language (EFL) Learners. To achieve the purpose of the study, first, the Preliminary English Test (PET) was administered for ensuring the homogeneity of the sample. Once the homogeneity was established, a total of 52 EFL intermediate students were selected and placed into two comparative and two control groups, with 13 participants in each group. Four groups took part in the study, with two groups undergoing treatment with the non-VR teaching approach of paragraph writing and two groups undergoing treatment of VR-enhanced education. Among these four groups, two consisted of introverts and two extroverts that were identified through Eysenck Personality Inventory. The two comparative groups received 12 sessions of VR-enhanced education in online classes (instead of drawing pictures and sharing them within their group, they watched the process activities in the VR environment.), but the control group received learning writing paragraphs through using instructor’s instructional materials. After 6-weeks of treatment sessions, all participants of the study took the post-test. According to the results, the VR-enhanced education was more effective than the non-VR teaching approach in developing paragraph writing of both introverts and extroverts. Moreover, the results of the research showed no significant differences between the performance of the introverts and extroverts, meaning that both had the same performance. The results of this study may pave the way for teachers to use VR-based technology in online and traditional classes without worrying about how learners with different personality traits respond.
Content analysis of the online information available about back pain
Authors: Suhail Ammar , Quais Sarah 
Published: June 2022

Abstract
Background
Low back pain (LBP) is growing health concern that affects millions of people around the globe, and there are many misconceptions regarding causes, imaging, and appropriate treatment choices. Common people usually search Google seeking information regarding LBP from different websites. However, the content of these widely accessible websites have not be evaluated in the light of evidence. The present study aims to analyze the information presented by these websites, summarize the content, and evaluate it against the published literature.

Methods
We conducted a systematic search of Google using search terms “low back pain,” “back pain,” “backache. NVivo software was used to capture the content from the internet. Content analysis (CA) was used to analyze online consumer information concerning LBP on the included websites.

Results
A total of 53 websites were included in the study by screening the search pages. There were erroneous information present on majority of the websites. Almost all of the websites consisted of nocebic terms. The causes were more oriented towards biomedical model. Treatment options mentioned did not concur with the recent clinical practice guidelines.

Conclusion
The Online information retrieved from a Google search lacks representation of the current best research. The findings of the study suggest that future development of websites must include information that is more accurate, and evidence driven. Online LBP information should be based on criteria that are more sensitive to the psychosocial factors that contribute to pain.