bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome of Ultrafiltration in On-pump vs Off-pump Coronary Artery Bypass Grafting in Patients with Renal Impairment
Authors: Phothukun Amarit , Nawarawong Weerachai , Tantraworasin Apichat , Tepsuwan Thitipong 
Published: June 2022

Abstract
Objective: Cardiopulmonary bypass circuit (CPB) is a technique used in conventional coronary artery bypass grafting (CABG) that cause many adverse effects including renal dysfunction. Ultrafiltration (UF) removes excess fluid and inflammatory mediators that result from the exposure to the CPB. Therefore, conventional CABG with UF and Off-pump CABG (OPCAB) could provide comparable protective option in reducing adverse effects of CPBMethod: A retrospective study of the chronic kidney disease (CKD) patients who underwent CABG. The renal outcomes were compared between the patients who underwent conventional CABG with UF and the patients who underwent OPCAB. A repeated measure mixed model adjusted by propensity score was used for comparing the renal outcome. Univariable and multivariable logistic regression was used to identify the risk factors for acute renal failure (AKI) and adverse outcomes.Results: From January 2009 and June 2020, there were 220 CKD patients, 109 (49.55%) patients underwent CABG with UF and 111 (50.45%) patients underwent OPCAB. There were statistically significant differences in the change of the average level of creatinine between CABG with UF (increased +0.09 mg/dl) and OPCAB (decreased -0.05 mg/dl) (p=0.043). Also, patients who underwent CABG with UF had significantly increased risk for AKI (OR = 5.38, p=0.038, 95CI 1.09, 26.5)Conclusion: OPCAB tend to provide better renal preservation and protection against post-cardiac surgery AKI than CABG with UF. OPCAB, if technically feasible, would be a preferable choice for patients with renal dysfunction. Study registration number: SUR-2562-06607/Research ID: 6607
Halloysite nanotubes for regulating thermodynamics and kinetics of polysulfone/poly (ethylene-co-vinyl alcohol) copolymer mixed matrix membranes with enhanced antifouling, permeability, and mechanical strength
Authors: Li Jianxin , Kadanyo Sania , Matindi Christine N , Dlamini Derrick , Hu Yunxia , Cui Zhenyu , He Benqiao , Mamba Bhekie , Gumbi Nozipho 
Published: June 2022

Abstract
In this study, hydrophilic halloysite nanotubes (HNTs) and poly (ethylene-co-vinyl alcohol) (EVOH) were mixed with hydrophobic polysulfone (PSF) in the presence of polyethylene glycol (PEG) to fabricate mixed matrix membranes (MMMs) free of macrovoids and enhanced performance via non-solvent induced phase separation (NIPS) technique. Various analytical techniques were used to probe the MMMs in terms of surface and cross-sectional morphology, functional groups, hydrophilicity, and mechanical strength. The separation and antifouling properties of PSF/EVOH/HNTs membranes were performed by bovine serum albumin (BSA) solution and gasoline (Oil) emulsion. The results showed delayed demixing and the formation of PSF/EVOH-MMMs with a spongy structure when the content of HNTs in the casting solutions was varied from 0.06–0.12 wt.%, owing to the formation of strong hydrogen bonds between PSF, EVOH, PEG and HNTs, which was confirmed by molecular dynamics (MD) simulations. The mechanical strength of the MMMs with 0.12 wt.% HNTs was increased 2.2-fold (up to 6.22 MPa), while the contact angle (CA) was the lowest at 47.42 ± 1.9°, indicating a significant increase in hydrophilicity. The underwater super oleophobic CA of the MMMs (169◦) also showed a 21% improvement over the pristine membrane (137◦). At the same time, the water permeability increased by a factor of 1.7 up to 419 L m− 2 h− 1 bar − 1 compared to the pristine membrane (0 wt.% HNTs) (246 L m− 2 h− 1 bar − 1). The rejection rates of MMMs (M12) for oil and BSA were > 90% and > 95%, respectively. After three cycles of fouling and cleaning experiments, the MMMs had > 90% flux recovery for both oil and BSA. In conclusion, this study demonstrates a new way to control the dope thermodynamics, formation dynamics, as well as morphology of MMMs by using the synergy of HNTs and polymers while maintaining promising properties for an improved separation performance of the UF membrane.
New machine learning ensemble for flood susceptibility estimation
Authors: arabameri alireza , Costache Romulus , Costache Iulia , Crăciun Anca , Pham Binh Thai 
Published: June 2022

Abstract
Natural disasters in particular have resulted in several economic losses that are resulting from an exponential increase in the number of economic losses in general across the globe. The floods are among the most severe natural hazards phenomena that affect the people aroung the world. Due to this fact, the identification of zones highly susceptible to floods became a very important activity in the researchers works. In this context, the present research work aims to propose the following 3 novel ensembles to estimate the flood susceptibility on Putna river basin from Romania: UltraBoost-Weights of Evidence (U-WOE), Stochastic Gradient Descending-Weights of Evidence (SGD-WOE) and Cost Sensitive Forest-Weights of Evidence (CSForest-WOE). In this regard a sample of 132 flood locations and 14 flood predictors was used as input dataset in the 3 aforementioned models. The modelling procedure performed through a ten-fold cross-validation method revealed that the SGD-WOE ensemble model achieved the highest performance in terms of ROC Curve-AUC (0.953) and also in terms of Accuracy (0.94). The slope and distance from river flood predictors achieved the highest importance in terms of flood susceptibility genesis, while the aspect, TPI, hydrological soil groups and plan curvature have the lowest influence in terms of flood occurence. The area with high and very high susceptibilty represents between 21% and 24% of the Putna river basin from Romania.
GOLPH3 promotes cell proliferation and malignancy in Hypopharyngeal squamous cell carcinoma via AKT-mTOR axis activation
Authors: Liu Jianmin , Zhou Tao , Wang Yongkuan , Cao Shuwei , Zhang Meng 
Published: June 2022

Abstract
Hypopharyngeal squamous cell carcinoma (HSCC) is a type of the head and neck squamous cell carcinoma (HNSCC), and it tends to have malignant transformation and result in poor prognosis effected by oncogene. Studies have shown that Golgi phosphoprotein 3 (GOLPH3) is highly expressed in HNSCC, which can activate AKT-mTOR signaling pathway. However, the functions of GOLPH3 in HSCC was unclear. Based on the analysis of 520 patients from The Cancer Genome Atlas (TCGA) database, we employed GOLPH3 stable knockdown and overexpression of FaDu cell lines to investigated that function and impact of GOLPH3 on HSCC in vitro and vivo. The functions and pathway of genes that positively related to GOLPH3 via enrichment analysis and western blot. Our results showed that GOLPH3 promotes HSCC cells proliferation, migration and subcutaneous tumor in vivo. We confirmed the positive correlation between GOLPH3 and AKT-mTOR signal activation in vitro. Enrichment analysis indicated that GOLPH3 is critical for HSCC development. Taken together, GOLPH3 promotes tumor cells proliferation and malignancy via AKT-mTOR signal activation, and this mechanism may be a key factor for HSCC tumor malignancy. It may provide an important target for clinical treatment of HSCC.
A novel transcript of LncRNA ELDR promotes chondrocyte senescence and osteoarthritis progression by tuning chromosomal dynamics
Authors: Lu Jun , ji Ming liang , Li Zhuang , Chang Qing , Geng Rui , Zhou Zhi wen , Lin Yu cheng 
Published: June 2022

Abstract
Epigenetic reprogramming plays a critical role in chondrocyte senescence during osteoarthritis (OA) pathology, but the underlying molecular mechanisms remain to be elucidated. Here using large-scale patient data sets and genetically engineered (Col2a1-CreERT2;Eldrflox/flox and Col2a1-CreERT2;ROSA26-LSL-Eldr+/+ KI) mouse models, we show that a novel transcript of long noncoding RNA ELDR is essential for the development of chondrocyte senescence. ELDR is highly expressed in chondrocytes and cartilage tissues of OA. Mechanistically, exon 4 of ELDR physically mediates a complex consisting of hnRNPL and KAT6A to regulate histone modifications of the promoter region of the IHH gene, thereby activating hedgehog signaling and promoting chondrocyte senescence. Therapeutically, GapmeR-mediated silencing of ELDR in OA model substantially attenuates chondrocyte senescence and cartilage degradation. Clinically, ELDR knockdown in cartilage explants from OA patients decreased the expression of senescence markers and catabolic mediators. Taken together, these findings uncover a previously uncharacterized lncRNA-dependent epigenetic driver in chondrocyte senescence, highlighting that ELDR could be a promising therapeutic avenue for OA.
The role of susceptibility, exposure and vulnerability as drivers of flood disaster risk at the parish level
Authors: Santos Pedro Pinto , Pereira Susana , Rocha Jorge , Reis Eusébio , Santos Mónica , Oliveira Sérgio Cruz , Garcia Ricardo A. C. , Melo Raquel , Zêzere José Luís 
Published: June 2022

Abstract
Fluvial flooding continues to be a process that has a major impact on society, the environment and the economy. Although its triggering factors are natural, the spatial configuration of exposure and vulnerability is expected to play a relevant role in explaining the damage records. The starting point of this research is the use of existing flood susceptibility, exposure and social vulnerability mapping, produced at the parish level, as input data in a Classification and Regression Trees model. The model uses as a dependent variable, separately, two databases of flood damage: one with the most severe losses from the DISASTER database, and another that sums the DISASTER cases and the lower impact damages. The results show a quite distinct classification of parishes, whether one database is used or the other. The DISASTER database reveals susceptibility has the most relevant flood risk driver in explaining the damage patterns, while the database with all the cases identifies exposure as the more relevant driver. In the end, the degree of damages has documented in databases is conditioned by the geographical distribution and overlay configuration of the three flood risk drivers. Finally, the CART classification groups are analyzed at the light of the European Union’s Floods Directive areas of significant potential flood risk. This analysis showed that the Directive’s parishes are interpreted differently - in terms of their positioning in face of the risk drivers – which is explained by the use of distinct impacting-criteria in the construction of the flood damage databases.
The Performance Analysis of 802.11p with Cooperative Communication and Dynamic Contention Window
Authors: Septa Neha , Rathod Devichand 
Published: June 2022

Abstract
Road safety applications provided by the Vehicular ad hoc networks demand less delay, high throughput, and reliable communication under highly dense traffic conditions. It becomes very challenging to design a network that suits the high mobility of vehicles and frequently changing network topology. To overcome these challenges in the network, we propose a new algorithm to dynamically adapt the contention window size (DYCW) to the vehicle density conditions. Along with that, we have introduced a cooperative relay vehicle for relaying the safety messages that failed to reach the destination. We have also carried out analytical study of the proposed model and the simulation results for the our model show that using DYCW enhances the system functioning by leading to higher throughput with stability in the performance and decreases both the delay and the packet drop ratio (PDR) of the system.
Satisfaction survey on a preoperative explanation method using 3-dimensional breast imaging for breast cancer patients considering breast conserving surgery
Authors: Ozaki Yuri , Kotani Haruru , Adachi Yayoi , Sawaki Masataka , Hattori Masaya , Yoshimura Akiyo , Kataoka Ayumi , Nozawa Kazuki , Sugino Kayoko , Horisawa Nanae , Endo Yuka , Takatsuka Daiki , Isogai Ayaka , Iwata Hiroji 
Published: June 2022

Abstract
PurposeWomen diagnosed with early breast cancer are faced with a choice of surgical procedures. Although one of the essential factors in surgical shared decision making is the impact on the body image, the breast morphology after breast conserving surgery is particularly difficult to explain in a uniform manner due to large individual differences. MethodsPatients with breast cancer eligible for breast conserving surgery (BCS) were recruited between June 2020 and October 2021. We surveyed the patients’ satisfaction with our explanation method about breast morphology after BCS using 3D breast imaging in the form of a questionnaire.ResultsA total of 162 patients were enrolled and 137 (84.6%) answered the questionnaire. One hundred and sixteen patients (84.6%) answered that they were very satisfied or satisfied with our explanation method and 100 (73.0%) patients were very satisfied or satisfied with the 3D breast imaging. Some patients answered that visually understanding the breast morphology by 3D breast imaging helped them to prepare for BCS, or on the contrary, made them chose mastectomy with breast reconstruction because the postoperative deformation of BCS was found to be unacceptable. Only a few patients who actually underwent BCS felt that their postoperative morphology was more deformed than the preoperatively imagined one.ConclusionOur results suggest that our preoperative explanation method using 3D breast imaging was useful for shared decision making. We think that 3D breast imaging can help the patients to visualize the individual shape of their breast, and the tumor position and size.
Correlation between Default mode network and Symptomatic Domains: A Spectral Approach to Schizophrenia
Authors: Sánchez Ana María Granados , Zapata Juan Felipe Orejuela , Dávila César Augusto Arango , Arango Isabella Moreno 
Published: June 2022

Abstract
Introduction
When evaluating psychiatric pathologies using imaging studies, the categorical approach supposes a significant challenge. Redefining these pathologies with the use of behavioral dimensions that are related to brain biology has been attempted. This paper aims to describe the findings on functional magnetic resonance imaging in patients with schizophrenia and correlate it with their symptomatic domains.
Materials and methods
This study is a descriptive, observational, transversal study. Fourteen patients with schizophrenia and Fourteen controls were explored using functional magnetic resonance during a resting period and developing easy, medium, and complex tasks. The default mode network was evaluated, registering the voxel activation on a cluster and its maximum activation over interest areas. Subjects were interrogated using the Derogatis Symptom Checklist (SCL-90-R) and correlation coefficients were applied for data analysis.
Results
Diminished activation of the default mode network was evidenced in association with the complexity of the task in the control group. Patients presented a steady activation when comparing their resting state with the activation during the different tasks. A negative correlation was observed implicating the volume of the functional cluster in the posterior cingulate cortex during the high complexity task and the interpersonal sensitivity domain. A moderate positive correlation was found with symptomatic domains of interpersonal sensitivity, hostility, phobia, and depression, while a moderate negative association was found with psychosis.
Conclusions
Imaging evaluation of the psychiatric pathologies could be useful if the pathology is approached through the spectrum of symptomatic domains. This perspective would enhance the assertiveness of the therapeutics.
How can Chinese petrochemical companies achieve the “Dual Carbon” goal? A scenario-based system dynamics analysis
Authors: Yu Xianyu , Zhou Kangjie , Zhou Dequn , Wang Qunwei , Sang Xiuzhi 
Published: June 2022

Abstract
With the pressure of achieving the “Dual Carbon” goal (carbon peak in 2030 and carbon neutrality in 2060) goal, it is very important to explore the appropriate carbon emission reduction strategy for petrochemical company. Based on an integrated analysis of alternative carbon emission reduction methods and national carbon emission reduction policies, simulation scenarios of carbon emission reduction strategies for petrochemical companies were designed in this study. A corresponding scenario-based system dynamics (SD) simulation model was then constructed to analyze the effect of each carbon emission reduction strategy. The obtained simulation results show that a petrochemical company implementing an aggressive carbon emission investment strategy will obtain the best emission reduction effect. Corresponding carbon emissions will begin to decline in 2030 and carbon neutrality will be achieved by 2058. It is suggested that, in the short term, petrochemical companies focus on carbon reduction technology innovation, which will help to reduce carbon emissions stably and quickly. In the long run, petrochemical companies should pay more attention to carbon capture, utilization, and storage to achieve the carbon neutrality goal no later than 2060. It is further recommended that the Government implements loose carbon emission reduction policies for the petrochemical companies to ensure economic development and carbon emission reduction investment by petrochemical companies.
MRC2 overexpression combined with intronic hypomethylation: potential predictors for glioma
Authors: Hua Shi , Cheng Yanhao , Zhang Moxuan , Dai Chao , Wang Wenlai , Li Hongyan , Lu Yucheng 
Published: June 2022

Abstract
Purpose
This study mainly to explore the effect of DNA methylation on the MRC2 expression, and the mechanism of MRC2 regulating the biological function of glioma cells.
Methods
MRC2 was found to be differentially expressed in glioma after large-scale screening of expression data. Logistic regression and Pearson correlation coefficient (r) scaled the correlation between MRC2 expression and clinical characteristics; immunohistochemistry and Western blot verified the expression of MRC2. ROC, Cox and Kaplan-Meier approach for quantifying MRC2 expression on survival. GSEA predicted signal pathways that may be activated by high expressed MRC2.
Results
High expression of MRC2 accompanied by promoter and intronic hypomethylation in glioma was related to survival rate, recurrence, tumor grade, chemotherapy, IDH_mutation, 1p19q_codeletion. Six pathways activated by highly expressed MRC2 were mainly regulated the proliferation and invasion in glioma. Co-expressed genes of MRC2 could be found in each pathway, and they were functionally consistent with MRC2.
Conclusion
The up-regulated MRC2 expression was related to promoter and intronic hypomethylation in glioma. Signal pathways activated by MRC2 mainly regulated the proliferation and invasion in glioma, and led to poor prognosis. MRC2 could be seen as a novel molecular target for glioma.
Early-phase pandemic in Italy: Covid-19 spread determinant factors
Authors: Urso Patrizia , Cattaneo Andrea , Pulvirenti Salvatore , Vercelli Franco , Cavallo Domenico Maria , Carrer Paolo 
Published: June 2022

Abstract
Although the Covid-19 pandemic is more than two-years ongoing, the environmental factors beyond virus diffusion are still partially unknown. This statistical study investigates the early phase of pandemic in Italy, as its heterogeneity in pollution levels and climate conditions provides an ideal scenario for an ecological study. The selected period excludes important confounding factors, as different virus variants, restriction policies or vaccines. The short-term relationship between the infection maximum increase and demographic, pollution and meteo-climatic parameters was investigated, including both winter-spring and summer 2020 data, also focusing separately on the two seasonal periods and on North vs Centre-South. Among main results, the importance of population size confirmed social distancing as a key management option. The pollution hazardous role undoubtedly emerged, as NO2 affected infection increase in all the studied scenarios, PM2.5 manifested its impact in North of Italy, while O3 always showed a protective action. Whereas higher temperatures were beneficial, especially in the cold season with also wind and relative humidity, solar irradiance was always relevant, revealing several significant interactions with other co-factors. Presented findings address the importance of the environment in Sars-CoV-2 diffusion and suggest prevention strategies in crowded areas, especially if highly polluted and weakly exposed to sun.
GWAS analysis of grain color and tannin content in Chinese sorghum based on resequencing technology
Authors: Zhang Liyi , Xu Jianxia , Ding Yanqing , Cao Ning , Gao Xu , Li Kuiying , Feng Zhou , Cheng Bing , Zhou Lengbo , Ren Mingjian , Tao Yuezhi , Xin Zhanguo , Zou Guihua 
Published: June 2022

Abstract
Sorghum is mainly used for brewing distilled liquors in China. Since grain tannins play an important role in liquor brewing, accurately understanding the relationship between grain color and tannin content can provide basis for selection standards of tannin sorghum. We resequenced a panel of 242 Chinese sorghum accessions and performed population structure and GWAS analysis to identify QTLs affecting pericarp color, testa pigment, and tannin content. Dendrogram, principal component analysis (PCA), and admixture model were used to infer population structure. Two distinct genetic sub-populations were identified according to their corresponding northern and southern geographic origin. To investigate the genetic basis of natural variation in sorghum grain color, a genome-wide association study (GWAS) with 2,760,264 SNP was conducted with multiple models (Blink, FarmCPU, GLM, and MLM). The four models identified 1090, 259, 32 and 251 SNP loci for the color of exocarp, mesocarp, testa, and tannin content, respectively. These SNPs were distributed in 440 SNP peaks. Some novel quantitative trait loci for sorghum pericarp color, testa pigments and tannin content colocalized with homologous genes in the flavonoid biosynthetic pathway from other plants, including an orthologue of maize ( Zea mays ) bz2 and homologues of Arabidopsis ( Arabidopsis thaliana ) TT2 , TT12 , and TT16 . Our investigation of the variation in grain color and tannin content in Chinese sorghum germplasm may help guide future sorghum breeding for liquor brewing.
Scanning Electron Microscopy and Metabolite Measurement Revealed the Stress Mechanism of PS-COOH Microplastics on Rhodotorula mucilaginosa AN5
Authors: Ma Jiahao , Meng Xiangfei , Li Zixin , Li Lexian , Xu Jiwen , Kan Guangfeng 
Published: June 2022

Abstract
Microplastics in the marine environment have been paid more and more attention by researchers, and the impact of these substances on marine microorganisms can not be ignored. This study aims to pay attention to the effect and mechanism of microplastics (80 nm PS-COOH) on Antarctic marine yeast, Rhodotorula mucilaginosa AN5. In our work, Scanning Electron Microscopy (SEM) was used to observe the morphology of yeast cells under microplastic stress, and metabolite analysis was used to explore the possible mechanism of yeast cell damage. The results showed that: (1) a certain concentration of PS-COOH could inhibit 40% growth of yeast cells and destroy the cell morphology. (2) Physiological and biochemical changes showed that under PS-COOH stress, the level of reactive oxygen species (ROS), malondialdehyde (MDA) content and the activities of antioxidant enzymes such as catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD) of R. mucilaginosa AN5 increased from 34–66%. It can be guessed that yeast can eliminate excess ROS in cells by the activity of oxidative kinases increased and maintain the balance of reactive oxygen species in cells.