bluuebunny/crossref_metadata_2025_split huggingface dataset:
APPLICATION OF SMART TECHNOLOGIES IN MODERN EDUCATIONAL INSTITUTIONS: INNOVATION, FLEXIBILITY, CREATIVITY
Authors: Karamanov Oleksiy , Voytovich Tetyana 
Published: November 2022

The article considers various aspects of the application of smart technologies and smart education (smart learning) in the modern educational space. The authors emphasize that smart education is a reflection of a new type of education system aimed at the process of acquiring skills and competencies for flexible and adapted interaction of pupils and student youth with the social, economic and technological environment.
The idea of smart education is based on the provision of various educational services, the creation of individual educational trajectories, the use of global open educational resources and creates real opportunities to use the advantages of the global information society to ensure educational needs and interests.The basic principles of smart education and the role of modern smart technologies in the domestic educational space are defined, their innovative and creative character is emphasized.The article points out the importance and necessity of taking into account three important elements of smart education in education, which determine the disclosure of its potential - innovation, flexibility and creativity.
The Effects of High Fat Diet on Kidney and Lung Histopathology in Experimental Rats
Authors: Al-Mayyahi Rawaa S. , Manal Nasser Al-Hayder  , Rawaa M.O. Hraishawi  
Published: November 2022

High fat diet and obesity have been considered as a main risk factor for various diseases such heart disease, chronic kidney disease and respiratory diseases. However, the precise effect of high fat diet on lung and kidney histopathology is limited. The present study examined the effects of high fat diet on rat histopathology. Female albino Wistar rats of four-week-old were fed either a basic diet or a high-fat diet (20% of fat). After one month of feeding, the histopathological analysis of kidney and lung was investigated. The kidney tissue of rats fed with high-fat diet presented several alterations including variable size of glomeruli, bleeding and congested blood vessels and deformations of several tubular structures compared with those that fed a basic diet. While the lung parenchyma of rats fed with high fat diet showed collapsed alveoli separated by thick inter-alveolar septa, infiltration of inflammatory cells and congested blood vessels were also observed. In conclusion, the high fat diet is responsible for detectable changes in kidney and lung in female rat and this type of diet may lead to renal and respiratory deformities as a result of its histopathological effects.
Frequency of urinary tract infections in renal transplant recipients with common bacteria and its sensitivity
Authors: Hazrat ullah  , Nasir Khan  , Asif Malik  , Ata Ur Raman  
Published: November 2022

Objective: To determine the frequency of urinary tract infection and its common pathogens with antibiotic sensitivity among renal transplant recipients.
Materials and methods:
This Cross sectional descriptive study was conducted at Institute of Kidney Diseases (IKD) Hayatabad, Peshawar from January 2008 to December 2012. The cross section included 74 live related renal transplant recipients. Each renal transplant recipient was followed up for 3mpnths for developing urinary tract infection.
Results:
A total of 74 patients were followed after renal transplant. Among them 12 (16.22%) were females and 62 (83.78%) were males respectively. They were all live related renal transplant. UTI developed in 27/74 (36.48%) patients at first 3 months after transplantation (60 ± 15 days). Female patients were more susceptible to UTI than male patients (5 female 41.66%; 22 male 35.48%). On univariate analysis, older age (p?=?0.015), female gender (p?<?0.001), hyperglycaemia (p?=?0.037) and acute rejection episodes (p?=?0.046) were all risk factors for developing urinary tract infection. Isolated bacteria were Escherichia coli (59.25%), Candida albicans (18.51%), Klebsiella (11.11%), Enterococcus spp. (7.40%), followed by Pseudomonas aeruginosa 3.70%. Antibiotic resistance was 26% for ciprofloxacin and 33% for ampicillin.
Conclusion: Urinary tract infection is a major problem in renal transplant recipients. The female gender, increasing age and uncontrolled hyperglycemia are the risk factors for UTI in renal transplant recipients. There is high resistance to ampicillin and quinolones in renal transplant recipients.
Antioxidant Activity and GC-MS Analysis of the Essential Oil of Amygdalus Spinosissima Seeds Grown in Balochistan
Authors: Zohra Kaneez  , Muhammad Masood Tariq Kiani  , Tahir Hameed  , Muhammad Aleem Akhtar  , Nazeer Ahmed  , Amna Bano  , Umair Ahmed  , Muhammad Kamal Tayyab  
Published: November 2022

Background: Amygdalus Spinosissima also known as Prunus Spinosissima belongs to the genus Prunus, its subgenus is Amygdalus. A. Spinosissima is a wild thorny almond found in approximately 600 to 1500 meters above sea level. Due to its medicinal value, it is used as traditional medicine all over the world. Methods: The objective of present work was to evaluate the antioxidant activity of essential oil of A. Spinosissima and other molecules present in the seed oil of this rare species A. Spinosissima through GC-MS. A. Spinosissima oil showed significant antioxidant activity with IC50 value of 09.0± 0.1 ?g/ml while IC50 value for ascorbic acid was 15.0± 0.5 ?g/ml. These results indicate that the antioxidant activity of the oil of A. Spinosissima is lower than that of ascorbic acid. Result: A. Spinosissima oil showed significant antioxidant activity with IC50 value of 09.0± 0.1 ?g/ml while IC50 value for ascorbic acid was 15.0± 0.5 ?g/ml. These results indicate that the antioxidant activity of the oil of A. Spinosissima is lower than that of ascorbic acid. A total of 17 compounds were identified in the essential oil from the seeds of A. Spinosissima where there were 3-hexanol (RT2.931), 2-pentanol,4-methyl( RT 2.996), Hydroperoxide,1-ethylbutyl(RT5.812), Hydroperoxide, 1-methylpentyl (RT6.045), Benzaldehyde(RT6.134), Phenol (RT 6.645), Benzyl alcohol (RT8.021), 3-Ethyl-3-methylheptane (RT8.695), Benzene, 1,3-bis(1,1-dimethylethyl)- (RT14.183), 2-Decenal, (E)- (RT14.373), 2,4-Decadienal, (E,E)- (RT15.847), Oleic Acid(RT32.912), Hexadecanamide (RT33.739), 9,12-Octadecadienoic acid (Z,Z)-,2-hydroxy-1-(hydroxymethyl) ethyl ester (RT37.662), 9-Octadecenamide, (Z)- (RT38.397), Diisooctyl- phthalate(RT42.179) and Gamma-tocopherol (RT38.397). Conclusion: The GC-MS and antioxidant activity of the A. Spinosissima seed essential oil is comparable with some other essential oils. Based on result, the seed oil may not be considered as potential sources of vegetable oil. Therefore, cannot be used as potential source in soap making industry but could be used in cosmetic industries due to vitamin E existence and antioxidant activity.
ПСИХОЛОГІЧНІ ОСОБЛИВОСТІ ПРОФЕСІЙНОГО СТРЕСУ ФАХІВЦІВ СОЦІОНОМІЧНОГО ПРОФІЛЮ
Authors: КОМАР Таїсія , ВАРГАТА Оксана 
Published: November 2022

У статті розкрито сутність професійного стресу фахівців соціономічного профілю. Досліджено психологічні особливості стресу, від яких залежить ефективність професійної діяльності фахівців соціономічного профілю. Уточнено сутність понять: стрес, стресори, професійний стрес, професійний стрес фахівців соціономічного профілю, інформаційний стрес, емоційний стрес, комунікативний стрес, еустрес, дистрес, гострий стрес, хронічний стрес, стресостійкість.
Дослідження психології професійного стресу, шляхів і засобів його корекції та профілактики має важливе значення для фахівців соціономічного профілю у цілому ряді життєвих і професійних подій. Проблема професійного стресу фахівців соціономічного профілю пов’язана із тим, що виконувана робота далеко не завжди відповідає необхідному рівню їх психологічної готовності витримувати інтелектуальні навантаження. У процесі професійної діяльності фахівці соціономічного профілю систематично піддаються психоемоційним впливам, пов’язаним із надмірними вимогами, високим рівнем контролю ситуацій, обмеженістю ресурсів щодо можливості їх зміни й удосконалення. Фахівцям соціономічного профілю дуже важливо навчитися не тільки виконувати професійні завдання, але й навчитися регулювати свій психоемоційний стан. Саме тому, психологія професійного стресу у сфері людина-людина, потребує більш детального вивчення.
Висвітлено результати емпіричного дослідження стресостійкості та оцінка адаптивних ресурсів фахівців соціономічного профілю до стресу. За результати дослідження визначено, що у переважної більшості фахівців соціономічного профілю середній рівень стресостійкості. Перспективою подальшого дослідження вбачаємо у розробці та впроваджені психокорекційної програми, яка сприятиме розвитку стійкості до стресових ситуацій та збереженню психічного здоров’я фахівців соціономічного профілю.
Perfil epidemiológico de traumas bucomaxilofaciais em um hospital de referência do interior da Bahia
Authors: Farias Lara Maria Gonçalves , Barros Débora Pereira Assis , Bertani Samylle Martins Sampaio , Silva Italo Emmanoel Silva e , D’Ávila Junior Elias Carlos , Moreira Larissa Nascimento , Santos Ana Karoline Ramos dos , Bromochenkel Cattiúscia Batista 
Published: November 2022

Objetivo: Analisar o perfil epidemiológico dos pacientes com traumas bucomaxilofaciais atendidos no Hospital Geral Prado Valadares em Jequié – BA. Metodologia: Trata-se de uma pesquisa descritiva de abordagem quantitativa, através de uma pesquisa documental, mediante aos prontuários dos pacientes envolvidos em traumas bucomaxilofaciais no HGPV em Jequié - BA no período de junho de 2018 a junho de 2021. Para a descrição das variáveis foram utilizadas frequência relativa e absoluta. Como também foi realizado a regressão logística multinominal para o cálculo do OddsRatio (Razão de Chances). E, o nível de significância adotado para os testes de hipótese foi de p-valor 0,05. Os dados foram tabulados no Microsoft Excel e posteriormente analisados no IBM StatisticalPackage For Social Science (versão 21.0). Resultados: O sexo masculino foi mais prevalente 80,6% (733), sendo que a faixa etária mais prevalente para esse grupo foi entre 19 a 30 anos com 29,6% (217) e a menor para os indivíduos com idade acima dos 61 anos com 8,6% (63) apenas. Em relação a etiologia o acidente de motocicleta foi mais prevalente no geral 35,4% (322). O não consumo de álcool se manteve mais prevalente em ambos os sexos, assim como o tratamento realizado. Porém, os locais mais afetados divergem onde para o sexo masculino fraturas de 1/3 médio da face foi mais prevalente 41,2% (302). Conclusão: Indivíduos do sexo masculino com idade entre 19 e 60 anos tiveram maior prevalência de acidentes de transito resultando em lesões maxilofaciais, sendo este com consumo de álcool, resultante em fraturas do 1/3 médio da face, com maior concentração no final de semana.
A importância do acompanhamento farmacêutico no período gestacional: os perigos da automedicação
Authors: Meneses Julie Alves Leão , Mendonça Larissa Aguiar de 
Published: November 2022

A gravidez é caracterizada por inúmeras alterações fisiológicas, que podem levar a uma diversidade de sintomas e a transtornos menores do tipo: gastrointestinais, como náuseas, refluxo ,constipação, lombalgia e cefaleia ,devido a esses fatores, as gestantes recorrem ao uso de medicamentos ,para alívio do seu desconforto, deve ser acompanhado por um profissional farmacêutico devido ao risco de um efeito tóxico ou teratogênico sobre o embrião/feto quando exposto à um determinado fármaco, podendo levar desde uma malformação congênita até a morte fetal, fato desconhecido entre a maioria das gestantes. O objetivo deste estudo foi avaliar o uso irracional de medicamento no período gestacional, revisando a segurança dos medicamentos mais utilizados na gestação, e a importância do acompanhamento farmacêutico. Para tanto, foi realizada uma revisão de estudo nas bases de dados Scielo (Scientific Electronic Library), Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde) por meio da plataforma BVS (Biblioteca Virtual de Saúde), PubMed site de acesso da base de dados Medline, com estudos identificados no período de 2016 a 2022. Resultados demostram a necessidade de auxiliar na conscientização a respeito das variáveis inerentes à gravidez, buscando exaltar a importância do farmacêutico neste período, como profissional adequado e responsável para promover o uso racional de medicamentos (URM).
Plantas medicinais no tratamento de gastrite
Authors: Aprigio Natallya Samilly Melo , Vasconcelos Tibério Cesar Lima de 
Published: November 2022

A gastrite é definida como uma patologia de caráter progressivo associada a um processo inflamatório da região da mucosa do estômago. Esta que pode eventualmente causar alterações celulares de um estado não atrófico para um estado atrófico até chegar a uma metaplasia intestinal e, por fim, neoplasia gástrica. Sua incidência e prevalência têm aumentado pela vida cotidiana, com aumento de maus hábitos alimentares, estresse e consumo crônico de álcool e outras drogas. Nessa perspectiva, sabendo que a utilização de produtos naturais de plantas medicinais no tratamento de patologias é muito ampla e eficaz no combate a infecções, o presente estudo objetivou, por meio de uma revisão de literatura, entender e discorrer sobre a fitoterapia utilizada no tratamento da gastrite. Na natureza, há uma grande variedade de antioxidantes naturais que são diferentes em sua composição, propriedades físicas e químicas, mecanismo e local de ação. Assim, apesar da existência de estudos intensivos sobre os teores químicos em inúmeras plantas mundialmente utilizadas na medicina popular para o tratamento de gastrites e úlceras, os dados completos de composição ainda são insuficientes para predizer todas as atividades e mecanismos de ação vigentes. Dessa forma, o uso de plantas medicinais como fitocêuticos ou em combinação com antibióticos para o tratamento de gastrite é um campo de pesquisa ativo.
Optimization of chondrocyte isolation from human articular cartilage to preserve the chondrocyte transcriptome
Authors: Shen Ping , Wu Peihua , Maleitzke Tazio , Reisener Marie-Jacqueline , Heinz Gitta A. , Heinrich Frederik , Durek Pawel , Gwinner Clemens , Winkler Tobias , Pumberger Matthias , Perka Carsten , Mashreghi Mir-Farzin , Löhning Max 
Published: November 2022

The isolation of chondrocytes from human articular cartilage for single-cell RNA sequencing requires extensive and prolonged tissue digestion at 37 C. Modulations of the transcriptional activity likely take place during this period such that the transcriptomes of isolated human chondrocytes no longer match their original status in vivo. Here, we optimized the human chondrocyte isolation procedure to maximally preserve the in vivo transcriptome. Cartilage tissues were transferred into a hypoxia chamber (4% O2) immediately after being removed from OA patients and minced finely. Collagenase II at concentrations of 0.02%, 0.1%, 0.25%, 0.5%, 1%, and 2% was applied for 0.5, 1, 2, 4, and 18 h to digest the minced tissue. Actinomycin D (ActD) was added to test its capacity in stabilizing the transcriptome. Cell yield, viability, cell size, and transcriptome were determined using counter chamber, flow cytometry, and RNA sequencing (RNA-seq). Collagenase II at 2% concentration released small chondrocytes from cartilage matrix during the first digestion hour and started to release large cells thereafter, reaching a complete release at 4 h. During 4-h digestions, collagenase II at 2% and 1% but not at lower concentrations yielded maximal release also of the large chondrocyte population. RNA-seq analysis revealed that a 4-h digestion period with 1% or 2% collagenase II plus Actinomycin D optimally preserved the transcriptome. Thus, this study provides an isolation protocol for single chondrocytes from human articular cartilage optimized for transcriptome preservation and RNA-seq analysis.
Percutaneous stent implantation for occluded central shunts in adults: A case report and review of current evidence
Authors: Jenab Yaser , Rezaee Malihe , Hosseini Kaveh , Ghaderian Homa , Haddad Raymond N. , Zaidi Ali N. 
Published: November 2022

BackgroundPatients with cyanotic complex congenital heart defects (CHDs) commonly undergo palliation with interposition of systemic-to-pulmonary shunts (SPSs). These palliative shunts are rarely found in adults with CHDs and can be complicated with progressive obstruction or total occlusion during follow-up. The best treatment option for shunt re-permeabilization is challenging and case-oriented because most patients are high risk candidates for redo surgeries. We aimed to review the current evidence on percutaneous stent implantation to treat failed SPSs.MethodsWe performed a comprehensive literature review on percutaneous stent implantation to treat failed and occluded SPSs. We also reported the case of a 33-year-old man with cyanotic CHD and an occluded central aorto-pulmonary shunt, who was successfully treated with percutaneous balloon dilatation and subsequently stent implantation at our institution.ResultWe identified and included 31 articles reporting on 150 patients and 165 stent implantations in failed SPSs. The age of patients at the time of stent implantation ranged from 6 days to 47 years. The time between the surgical shunt creation and transcatheter intervention ranged from 1 day to 17 years. Overall, 161/165 (97.5%) stent implantations were successful. The most common clinical presentation was cyanosis and decreased atrial oxygen saturations and the indication for stent implantation was shunt obstruction and stenosis.ConclusionThis review highlights the benefits of endovascular stenting to permeabilize failed SPSs in children and adults with complex CHD who are classified as poor candidates for re-surgical repair.
Development and validation of a predictive risk model based on retinal geometry for an early assessment of diabetic retinopathy
Authors: Wang Minglan , Zhou Xiyuan , Liu Dan Ning , Chen Jieru , Zheng Zheng , Ling Saiguang 
Published: November 2022

AimsThis study aimed to develop and validate a risk nomogram prediction model based on the retinal geometry of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) and to investigate its clinical application value.MethodsIn this study, we collected the clinical data of 410 patients with T2DM in the Second Affiliated Hospital of Chongqing Medical University between October 2020 and March 2022. Firstly, the patients were randomly divided into a development cohort and a validation cohort in a ratio of 7:3. Then, the modeling factors were selected using the least absolute shrinkage and selection operator (LASSO). Subsequently, a nomogram prediction model was built with these identified risk factors. Two other models were constructed with only retinal vascular traits or only clinical traits to confirm the performance advantage of this nomogram model. Finally, the model performances were assessed using the area under the receiver operating characteristic curve (AUC), calibration plot, and decision curve analysis (DCA).ResultsFive predictive variables for DR among patients with T2DM were selected by LASSO regression from 33 variables, including fractal dimension, arterial tortuosity, venular caliber, duration of diabetes mellitus (DM), and insulin dosage (P&lt; 0.05). A predictive nomogram model based on these selected clinical and retinal vascular factors presented good discrimination with an AUC of 0.909 in the training cohort and 0.876 in the validation cohort. By comparing the models, the retinal vascular parameters were proven to have a predictive value and could improve diagnostic sensitivity and specificity when combined with clinical characteristics. The calibration curve displayed high consistency between predicted and actual probability in both training and validation cohorts. The DCA demonstrated that this nomogram model led to net benefits in a wide range of threshold probability and could be adapted for clinical decision-making.ConclusionThis study presented a predictive nomogram that might facilitate the risk stratification and early detection of DR among patients with T2DM.
Role of constructed wetlands in mitigating the challenges of industrial growth and climate change impacts in the context of developing countries
Authors: Islam Md. Al Sadikul , Saeed Tanveer , Majed Nehreen 
Published: November 2022

One of the most persistent issues affecting individuals in developing countries is the lack of access to safe drinking water and sanitary facilities. The adoption of centralized water, energy, and cost-intensive technology has proven ineffective in addressing the complex water-related challenges that have arisen as a consequence of growing urbanization in developing nations. Constructed wetlands have emerged as an effective wastewater treatment solution with natural applications. The fundamental goal of this study is to offer a complete overview of the wide variety of practices, uses, and investigations of constructed wetlands systems for eliminating different pollutants from wastewater in developing countries leading to placing them in the context of climate change, environmental resource planning, and sustainable wastewater treatment systems. CWs offer significant levels of treatment performances with hybrid systems achieving contaminant removal efficiencies up to 93.82% for total suspended solids, 85.65% for chemical oxygen demand, and 80.11% for ammonia nitrogen which is adequate with respect to other viable alternatives. In terms of Biological Oxygen Demand (BOD5), the highest elimination (84.06%) was achieved in hybrid systems when compared to Free water surface CWs (65.34%), Horizontal sub-surface CWs (75.1%), and Floating treatment wetland (55.29%). The maximum power density generation through the microbial fuel cell-based constructed wetlands ranges between 50 and 86 mW/m2in Bangladesh (integrated tidal flow) and 852 mW/m3in China (vertical flow), and the production of bioenergy has been evidenced up to 1,836.5 GJ/hector/year. Annually, wastewater treatment plant systems (WTPs) generate around a hundred times more Methane (CH4), Nitrous oxide (N2O), and carbon dioxide (CO2) than CWs. In metropolitan cities, WTPs may lead to a considerable increase in upstream land use, which could be minimized by promoting CWs in these areas. The potential utility of different CWs in protecting and preserving estuarine quality within the present regulatory framework is finally addressed in the study, emphasizing that it can balance the impacts of industrial expansions in developing countries for subsequent mitigation and adaptation to climate change.