bluuebunny/crossref_metadata_2025_split huggingface dataset:
circAGFG1 Facilitates the Progression of Non-Triple-Negative Breast Cancer Through miR-143-5p/USP14 Axis
Authors: Yang Rui , Chen Hang , Chen Junxia 
Published: January 2022

Abstract
Circular RNAs (circRNAs) emerged as a new class of regulators in various human diseases, including breast cancer (BC). Our previous study identified that circAGFG1 could promote triple-negative breast cancer (TNBC) progression. However, the clinical values and functions of circAGFG1 in non-TNBC remain elusive. Here, we applied qRT-PCR in 30 pairs of non-TNBC tissues and para-cancerous tissues and in situ hybridization (ISH) in 346 paraffin-embedded non-TNBC tissues to evaluate the expression pattern and clinical significance of circAGFG1 in non-TNBC. Gain- and loss-of-function studies were carried out to determine the biological function of circAGFG1 in non-TNBC in vitro and in vivo. Mechanistically, RNA pull-down, RNA immunoprecipitation, dual luciferase reporter, fluorescent in situ hybridization assays were employed to validate the interaction between circAGFG1 and miR-143-5p as well as miR-143-5p and USP14. We found that circAGFG1 was markedly increased in non-TNBC tissues as well. Moreover, patient suffering from non-TNBC with a higher expression level of circAGFG1 presents a worse clinical outcome. Multivariate analysis uncovered that high level of circAGFG1 might serve as a standalone risk factor for non-TNBC patients. Functional studies substantiated that enforced expression of circAGFG1 increased the malignance of non-TNBC cells, whereas silencing of circAGFG1 produced the opposite. Mechanistic investigations proved that circAGFG1 sponged miR-143-5p to regulate the level of oncogene USP14, leading to the progression of non-TNBC. Taken together, our data revealed that circAGFG1 could also accelerate the progression of non-TNBC via miR-143-5p/USP14 axis and might provide an alternative target for the diagnosis and treatment of non-TNBC.
Using Water Quality Parameters To Predict Trihalomethane Ion Based On An Artificial Neural Network Model
Authors: Baboli Zeynab , Birgani Yaser Tahmasebi , Maleki Heidar , Angali Kambiz Ahmadi , Babaei Ali Akbar 
Published: January 2022

Abstract
Background: Trihalomethanes (THMs) are the first disinfectant by-products in the drinking water distribution network and classified as potential carcinogens. The presence of THMs in chlorinated water depends on the pH, water temperature, contact time between water and chlorine, type and dose of disinfection, bromide ion concentration, and type and concentration of natural organic materials (NOMs). In the present study, the formation of THMs was evaluated by water quality parameters and modeled by an artificial neural network (ANN) approach through five water distribution networks (WDNs) and Karoun river in Khuzestan province.Results: This study was conducted from October 2014 to September 2015. Results showed that THMs concentration ranged in five WDNs, including Shoushtar, Ahvaz 2, Ahvaz 3, Mahshahr, Khorramshahr, and Karoun river through N.D.-9.39 µg/L, 7.12-28.60, 38.16- 67.00, 17.15-90.46, 15.14-29.99 and N.D.-156, respectively.Conclusions: The concentration of THMs exceeded Iran and EPA standards in many cases in Mahshahr and Khorramshahr WDNs. Evaluation of R2, MSE, and RMSE showed the appropriate correlation between measured and modeled THMs, indicating good ANN potential for estimating THM formation in water sources.
Comparative Advantage of Tractor Utilization in Southeastern Oromia, Ethiopia.
Authors: Dawid Ibsa , Gebiso Tamrat , Boka Ephrem 
Published: January 2022

Abstract
This study analyzes the effect of tractorization on cropping intensity, crop yields, and adoption of major agricultural inputs, on human labor employment, determine the utilization and per-unit cost of tractor power according to the farm size, compare the different costs and profits for Draught animal power and Tractor operated farms according to the farm size. Data was collected from the stratified sample of 345 farmers from three purposively selected districts, Hexosa, Asasa, and Sinana, where the agricultural mechanization operations are becoming increasingly practiced. The Tobit model showed that wheat farmland size, tractor use, and labor for the adoption of the chemical fertilizers, land allocated for Wheatland and tractor use for the adoption of improved seed, and Age and total cultivated land for the adoption of agrochemicals affected positively and significantly. Tractorization has a positive and statistically significant effect on the adoption of chemical fertilizers and improved seed rate, except for the adoption of agrochemical applications. The average wheat production in all farms of tractor-operated farms was higher (34.67 qt ha-1) than other operated farms. There has been a reduction of total human labor employment to the extent of about 76 % on the tractor farms as compared to both the draught animal and mixed operated farms. The net income was higher on tractor-operated farms than both mixed and draught animal-operated farms. Therefore, the tractor-operated farms were economically more efficient than the draught animal power and mixed-operated farms especially in the case of farms of small and large farm sizes.
Independent Evaluation of Peg Travel and Reach Movement Time Using A Newly Developed Nine-Hole Pegboard
Authors: Tochio Kensuke , Kimura Daisuke , Kinoshita Hiroshi , Ryuhei Okuno , Fukui Takeshi 
Published: January 2022

Abstract
Background: Hand dexterity in patients is often assessed with the nine-hole peg test (NHPT). In this test, the time to complete the test is the only outcome variable. However, the evaluation time alone does not provide detailed information about test execution. By introducing a newly developed PC-connected nine-hole pegboard, we divided the peg test exercise into four parts, calculated the difficulty level, and clarified the characteristics of the NHPT. In addition, we provided baseline data of detailed NHPT performance in healthy young women.Methods: A pegboard with a container equipped with an accelerometer and nine holes with small photo reflectors at the bottom was developed for the present study. Pegboard features and peg dimensions were the same as those of a commercially available NHPT. Dominant and nondominant hands and container-to-peg hole distances (index of difficulty; ID) were analyzed as dependent variables for the four phases of the task in 16 healthy young women.Results: Handedness was examined using the Edinburgh Handedness Inventory, and all participants were strongly right-handed. It was possible to accurately measure the total performance time, peg movement time and reaching time for each task. The total performance time was shorter for the dominant (right) hand (15595.4 ± 1039.5 msec) than for the nondominant (left) hand (17494.4 ± 1478.7 msec) (P<0.001). Peg movement time showed an increase in performance time 900 ± 67.7 to 979.3 ± 112.2 as the task difficulty increased from an ID of 7.6 bits to 8.4 bits (P=0.035).Conclusions: The newly developed pegboard makes it possible to accurately and separately measure movement times with individual pegs and the time to reach pegs, without the need for stopwatch assessments. A detailed evaluation will clarify problems in upper limb function, suggest a training protocol, and identify problems needing intervention to develop future approaches to the rehabilitation of hand dexterity.Trial registrationNot applicable
Diversity-aware Unmanned Vehicle Team Arrangement in Mobile Crowdsourcing
Authors: Li Yu , Feng Haonan , Peng Zhankui , Zhou Li , Wan Jian 
Published: January 2022

Abstract
With the continuous development of mobile edge computing and the improvement of unmanned vehicle technology, unmanned vehicle could handle ever-increasing demands. As a significant application of unmanned vehicle, spatial crowdsourcing will provide an important application scenario, which is about to organize a lot of unmanned vehicle to conduct the spatial tasks by physically moving to its locations, called task assignment. Previous works usually focus on assigning a spatial task to one single vehicle or a group of vehicles. Few of them consider that vehicle team diversity is essential to collaborative work. Collaborative work is benefits from organizing teams with various backgrounds vehicles. In this paper, we consider a spatial crowdsourcing scenario. Each vehicle has a set of skills and a property. The property denotes vehicle’s special attribute, (e.g., size, speed or weight). We introduce a concept of entropy to measure vehicle team diversity. Each spatial task (e.g., delivering the take-out, and carrying freight) is under the time and budget constraint, and required a set of skills. We need to assure that the assigned vehicle team is diverse. To address this issue, we first propose a practical problem, called team diversity spatial crowdsourcing (TD-SC) problem which finds an optimal team-and-task assignment strategy. Moreover, We design a framework which includes a greedy with diversity (GD) algorithm and a divide-and-conquer (D&C) algorithm to get team-and-task assignments. Finally, we demonstrate efficiency and effectiveness of the proposed methods through extensive experiments.
Long Memory Recursive Prediction Error Method for Identification of Continuous-time Fractional Models
Authors: victor stephane , Duhé Jean-François , Melchior Pierre , Abdelmoumen Youssef , Roubertie François 
Published: January 2022

Abstract
This paper deals with recursive continuoustime system identification using fractional differentiation models. Long-memory recursive prediction error method is proposed for recursive estimation of all parameters of fractional order models. When differentiation orders are assumed known, least-squares and prediction error methods, being direct extensions of the classic methods used for integer order models, are compared to our new method, thus proving the efficiency of our algorithms. Then, when the differentiation orders are unknown, two-stage algorithms are necessary for both parameter and differentiation order estimation. The performances of the new proposed recursive algorithm is studied through Monte-Carlo simulations. Finally, the proposed algorithm is validated on a biological example where heat transfer in lungs is modeled by using thermal two-port network formalism with fractional models.
Multistability Route in a PWL Multi-scroll System through Fractional-Order Derivatives
Authors: Monroy José Luis Echenausía , Wang Ning , Huerta-Cuellar G. 
Published: January 2022

Abstract
Recently, it was discovered that the use of fractional derivatives induces the occurrence of multistable states in PWL systems with multiple scrolls. In this paper, we show the path of the system from monostable to multistable behavior by reducing the integration order. Using bifurcation diagrams, which describe the evolution of the attractor under the modification of the bifurcation parameter, and basins of attraction, we show that the system has a path to multistability, revealing the mechanism for the emergence of the behavior. The resulting dynamics shows the coexistence of up to n + 2 attractors, where n is the number of scrolls generated by the integer-order system. Moreover, the existence and uniqueness of the dynamics is proved by Poincar´e sections showing that the behaviors exist and coexist and are not a section of the same solution.
Weight Spectrum and Executive Function in Adolescents: The Moderating Role of Depression
Authors: Lin Qingmin , Jiang Yanrui , Sun Xiaoning , Zhang Yunting , Shan Wenjie , Zhao Jin , Wang Xuelai , Zhu Qi , Sun Wanqi , Lu Hui , Jiang Fan 
Published: January 2022

Abstract
Background: Overweight/obesity may impair executive function (EF). However, adolescent EF impairments across the weight spectrum were not well studied, with the moderating effect of negative emotions in the weight-EF association being limitedly investigated. We aimed to determine whether overall and abdominal weight spectrum associated with EF impairments and to identity whether negative emotions moderate the weight-EF link in adolescents.
Methods: We applied a subsample of the SCHEDULE-A project. Adolescents (11-18 years) were recruited using a multi-stage cluster random sampling approach. Overall and abdominal weight were measured by body mass index z-score and waist-to-height ratio, respectively. We used the Behavior Rating Inventory of Executive Function (BRIEF) to evaluate adolescent EF in nature setting, and utilized the Depression Anxiety and Stress Scales (DASS-21) to assess three types of negative emotional states (i.e., depression, anxiety, and stress).
Results: Of the 1 935 adolescents, 963 (49.8%) were male. We observed that abdominal, not overall, overweight was associated with the Global Executive Composite (GEC) impairment (OR = 1.59, 95% CI: 1.07-2.35), particularly for inhibit, emotion control, shift, working memory, and monitor domains. Furthermore, depression moderated the abdominal overweight-GEC association (P = 0.032 for interaction term), especially for emotional control, working memory, and initiate dimensions. Moreover, we also found abdominal thinness was associated with the Metacognition Index problem (OR = 1.33, 95% CI: 1.04-1.72), particularly for plan and monitor areas.
Conclusions: Both abdominal overweight and thinness were associated with adolescent EF, and depression would be a modifiable target to improve EF in adolescents with abdominal overweight.
Synovial Tissue Lymphoid Aggregates Are Associated With Response To Rituximab Therapy In Rheumatoid Arthritis Patients
Authors: Turk Matthew A , Low Candice , Orr Carl , Conway Richard , Murray Kieran , Young Francis , Molloy Eamonn , Mongey Anne Barbara , Fearon Ursula , Veale Douglas J. 
Published: January 2022

Abstract
Background: To evaluate the clinical and laboratory factors associated with long-term responses to rituximab therapy in patients with RA. Methods: One hundred fourteen RA patients received intravenous Rituximab between 2003-2016. Prior to treatment, arthroscopy and synovial biopsy was performed on a subgroup of this cohort who had active knee arthritis. Demographic, clinical, and outcome data were collected prospectively and immunohistology was performed on synovial tissue biopsies.Results: In the overall cohort, 89% of patients were seropositive for either RF (rheumatoid factor) or ACPA (anti-citrullinated protein antibodies). At baseline, median disease duration was 13.5 years. Seventy-four percent of patients had received a csDMARD and two thirds had received a bDMARD before rituximab. Rituximab monotherapy was used in 34 patients, while 80 patients received rituximab-csDMARD combination therapy. Twenty-six of the 68 patients in remission (38%) received rituximab monotherapy and 42/68 (62%) received combination therapy with a csDMARD. Twenty-four of 39 (62%) biologic naïve patients achieved remission on treatment with rituximab. Forty-four patients underwent an arthroscopy and synovial biopsy prior to treatment. Synovial tissue lymphoid aggregates (LA) were observed in 21 subjects, of which 17 (81%) showed complete or partial remission in response to treatment with rituximab. The presence of LA was significantly associated with rituximab-induced remission in these patients (p=0.007, OR=7.286 [1.737-30.555]). Conclusion: In this real world series, patients with RA demonstrate long-term, high response rates to rituximab therapy and synovial biopsy B-cell rich lymphoid aggregates are associated with a higher rate of good response.
MYC overexpression predicts poor prognosis and correlates with immune infiltration in chronic lymphocytic leukemia
Authors: Guo Dongmei , Li Ping , Wang Zan , Li Banban , Bi Gaofeng , Li Chunpu 
Published: January 2022

Abstract
Background: Chronic lymphocytic leukemia (CLL) is a highly genetically heterogeneous disease that represents 30% of adult leukemia. We aimed to identify survival-associated key genes in CLL and investigate potential immunotherapy targets.Methods: The survival information and microarray mRNA expression profiles of CLL patients were downloaded from the Gene Expression Omnibus (GEO) and the International Cancer Genome Consortium (ICGC) database. Hub genes were uncovered in CLL. The bioinformatics technology was applied to identify key genes and performe functional analysis. Finally, we explored the role of this key gene and the situation of immune infiltration in the bone marrow.Results: We uncovered 223 differentially expressed genes (DEGs) as hub genes associated with CLL. MYC was identified as the key gene in CLL. High MYC expression was associated with poor prognosis. The biological pathways such as "Hypoxia", "Myc Targets V2", "P53 pathway" etc, were remarkably linked with MYC high expression phenotype. The expression level of MYC was positively correlated with infiltration levels of Eosinophils and follicular helper T cells, while negatively correlated with infiltration levels of regulatory T cells.Conclusion: Overexpression of MYC predicts poor prognosis and correlates with immune infiltration. MYC could serve as a potential immunotherapeutic target for CLL.
Prognostic Nomograms Based on Microvascular Invasion Grade for Early-stage Hepatocellular Carcinoma Patients After Curative Hepatectomy
Authors: Ke Jingpeng , Ye Honghao , Lin Fangzhou , Shi Yingjun , Zhong Aoxue , Chen Hengkai 
Published: January 2022

Abstract
Background: This is the first study to develop and evaluate a predictive model based on the microvascular invasion (MVI) classification for early recurrence and survival after curative hepatectomy in patients with early-stage hepatocellular carcinoma (HCC).Methods: The database of patients with early-stage HCC who underwent curative hepatectomy in the First Affiliated Hospital of Fujian Medical University and the First Affiliated Hospital of Xiamen University were retrospectively reviewed. Kaplan-Meier curves and Cox proportional hazards regression models were used to analyze disease-free survival (DFS) and overall survival (OS). Nomogram models were constructed on the datasets from the First Affiliated Hospital of Fujian Medical University and the datasets were validated using bootstrap resampling with 30% samples as internal validation. Data of patients from First Affiliated Hospital of Xiamen University were used for external validation.Results: A total of 703 patients with early-stage HCC were included in our study. An eight-factor nomogram for predicting recurrence or metastasis and a six-factor for predicting survival were created. The concordance indexes (C-index) were 0.775 (95% confidence interval [CI], 0.720-0.830) for the DFS nomogram and 0.812 for the OS nomogram (95% CI, 0.732-0.892), respectively, in the training cohort, and 0.865 (95% CI, 0.806-0.924) and 0.839 (95% CI, 0.675-1.00), respectively, in the internal validation cohort, and 0.857 (95% CI, 0.763-0.951) and 0.842 (95% CI, 0.708-0.970), respectively, in the external validation cohort. The calibration curves showed optimal agreement between the predicted and observed DFS and OS rates. The predictive accuracy was significantly better than that of the classic HCC staging systems.Conclusions: This study developed and validated nomograms for predicting recurrence, especially early recurrence, and overall survival in early-stage HCC patients after curative resection with high predictive accuracy.
Male Mortality from Conditions Sensitive to Primary Care Under The Perspective of The National Men's Health Policy
Authors: de Paula Cácia Régia , Pelazza Bruno Bordin , de Lima Flavio Henrique Alves , Maia Ludmila Grego , de Araújo Reila Campos Guimarães , Tacsi Yolanda Rufina Condorimay , Ferri Lucila Pesuti , Meireles Gláucia Oliveira Abreu Batista , Ferreira Pedro Lopes , Sousa Ana Luiza Lima , Matos Marcos André , Barbosa Maria Alves 
Published: January 2022

Abstract
Background: To evaluate the trend of male mortality and its relationship with conditions sensitive to primary care (CSPCs), considering the coverage of the Family Health Strategy (FHS) and the implementation of the National Policy for Comprehensive Health Care of the Male (PNAISH).Methods: Ecological study of the time series of male deaths in the age group of 20 to 59 years, according to CSPC from 2009 to 2018 with data extraction from the Mortality Information System. The relationship between death rate due to CSPCs and FHS coverage was quantified by Spearman’s correlation. The trend in the number of deaths was adjusted by univariate quasi-Poisson regression models. Mortality trends were considered stationary (p > 0.05), declining (p < 0.05 and negative regression coefficient), or ascending (p < 0.05 and positive regression coefficient). Values of p < 0.05 were considered statistically significant.Results: CSPCs were responsible for 1,092,070 (19.2%) deaths in the 127 municipalities under study, a with year-on-year variation of -4.89% to 3.06% and showed no significant relationship with mean FHS coverage (r < 0.09; p < 0.160). PNAISH was implemented in 100% of the municipalities, and the FHS coverage showed a significant upward trend [95% CI; 1.03-1.09], with an annual average of 6%. The trend of deaths in the study groups due to CSPCs was generally stable (Exp (β) = 1.01; p > 0.593). Notably, deaths in specific groups increased over time: bacterial pneumonia, asthma, hypertension, epilepsy, kidney and urinary tract infections, and skin and subcutaneous tissue infections. The heart failure group showed a decreasing mortality rate (Exp (β) = 0.92; p = 0.008).Conclusions: The expansion of FHS coverage and the fact that PNAISH was implemented in all municipalities in the state of Goiás did not influence the rate of deaths due to CSPCs in general. The analysis of death trends due to CSPCs in general indicates stability in the investigated period. The present study, the first of its kind in country, allows an evaluation of actions related to PNAISH, confirming the need for urgent investments. It can serve as feedback to researchers and policy-makers on interventions in humans.