bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of performance for a key indicator of One Health: evidence based on One Health index for zoonoses in Sub-Saharan Africa
Authors: Zhao Han-Qing , Fei Si-Wei , Yin Jing-Xian , Li Qin , Jiang Tian-Ge , Guo Zhao-Yu , Xue Jing-Bo , Han Le-Fei , Zhang Xiao-Xi , Xia Shang , Zhang Yi , Guo Xiao-Kui , Kassegne Kokouvi 
Published: October 2022

Abstract
Background
Zoonoses are public health threats that cause severe damage worldwide. Zoonoses constitute a key indicator of One Health (OH) and the OH approach is being applied for zoonosis control programmes of zoonotic diseases. In a very recent study, we developed an evaluation system for OH performance through the global OH index (GOHI). This study applied the GOHI to evaluate OH performance for zoonoses in sub-Saharan Africa.

Methods
The framework for the OH index on zoonoses (OHIZ) was constructed including five indicators, 15 subindicators and 28 datasets. Publicly available data were referenced to generate the OHIZ database which included both qualitative and quantitative indicators for all sub-Sahara African countries (n = 48). The GOHI algorithm was used to estimate scores for OHIZ. Indicator weights were calculated by adopting the fuzzy analytical hierarchy process.

Results
Overall, five indicators associated with weights were generated as follows: source of infection (23.70%), route of transmission (25.31%), targeted population (19.09%), capacity building (16.77%), and outcomes/case studies (15.13%). Following the indicators, a total of 37 sub-Sahara African countries aligned with OHIZ validation, while 11 territories were excluded for unfit or missing data. The OHIZ average score of sub-Saharan Africa was estimated at 53.67/100. The highest score was 71.99 from South Africa, while the lowest score was 40.51 from Benin. It is also worth mentioning that Sub-Sahara African countries had high performance in many subindicators associated with zoonoses, e.g., surveillance and response, vector and reservoir interventions, and natural protected areas, which suggests that this region had a certain capacity in control and prevention or responses to zoonotic events.

Conclusions
This study reveals that it is possible to perform OH evaluation for zoonoses in sub-Saharan Africa by OHIZ. Findings from this study provide preliminary research information in advancing knowledge of the evidenced risks to strengthen strategies for effective control of zoonoses and to support the prevention of zoonotic events.
Plasma proteome profiling identifies changes associated to AD but not to FTD
Authors: Mofrad R. Babapour , del Campo M. , Peeters C. F. W. , Meeter L. H. H. , Seelaar H. , Koel-Simmelink M. , Ramakers I. H. G. B. , Middelkoop H. A. M. , De Deyn P. P. , Claassen J. A. H. R. , van Swieten J. C. , Bridel C. , Hoozemans J. J. M. , Scheltens P. , van der Flier W. M. , Pijnenburg Y. A. L. , Teunissen Charlotte E. 
Published: October 2022

Abstract
Background
Frontotemporal dementia (FTD) is caused by frontotemporal lobar degeneration (FTLD), characterized mainly by inclusions of Tau (FTLD-Tau) or TAR DNA binding43 (FTLD-TDP) proteins. Plasma biomarkers are strongly needed for specific diagnosis and potential treatment monitoring of FTD. We aimed to identify specific FTD plasma biomarker profiles discriminating FTD from AD and controls, and between FTD pathological subtypes. In addition, we compared plasma results with results in post-mortem frontal cortex of FTD cases to understand the underlying process.

Methods
Plasma proteins (n = 1303) from pathologically and/or genetically confirmed FTD patients (n = 56; FTLD-Tau n = 16; age = 58.2 ± 6.2; 44% female, FTLD-TDP n = 40; age = 59.8 ± 7.9; 45% female), AD patients (n = 57; age = 65.5 ± 8.0; 39% female), and non-demented controls (n = 148; 61.3 ± 7.9; 41% female) were measured using an aptamer-based proteomic technology (SomaScan). In addition, exploratory analysis in post-mortem frontal brain cortex of FTD (n = 10; FTLD-Tau n = 5; age = 56.2 ± 6.9, 60% female, and FTLD-TDP n = 5; age = 64.0 ± 7.7, 60% female) and non-demented controls (n = 4; age = 61.3 ± 8.1; 75% female) were also performed. Differentially regulated plasma and tissue proteins were identified by global testing adjusting for demographic variables and multiple testing. Logistic lasso regression was used to identify plasma protein panels discriminating FTD from non-demented controls and AD, or FTLD-Tau from FTLD-TDP. Performance of the discriminatory plasma protein panels was based on predictions obtained from bootstrapping with 1000 resampled analysis.

Results
Overall plasma protein expression profiles differed between FTD, AD and controls (6 proteins; p = 0.005), but none of the plasma proteins was specifically associated to FTD. The overall tissue protein expression profile differed between FTD and controls (7-proteins; p = 0.003). There was no difference in overall plasma or tissue expression profile between FTD subtypes. Regression analysis revealed a panel of 12-plasma proteins discriminating FTD from AD with high accuracy (AUC: 0.99). No plasma protein panels discriminating FTD from controls or FTD pathological subtypes were identified.

Conclusions
We identified a promising plasma protein panel as a minimally-invasive tool to aid in the differential diagnosis of FTD from AD, which was primarily associated to AD pathophysiology. The lack of plasma profiles specifically associated to FTD or its pathological subtypes might be explained by FTD heterogeneity, calling for FTD studies using large and well-characterize cohorts.
Exploring the private universe of Henri Matisse in The Red Studio
Authors: Haddad Abed , Pastorelli Gianluca , Ortiz Miranda Annette S. , Ludvigsen Loa , Centeno Silvia A. , Duvernois Isabelle , Hoover Caroline , Duffy Michael , Aviram Anny , Zycherman Lynda 
Published: October 2022

Abstract
The exhibition Matisse: The Red Studio allowed for an in-depth study of The Red Studio (1911) and six of the works featured in the painting by Henri Matisse (1869–1954) of his studio in Issy-les-Moulineaux near Paris. The grouping includes three paintings from the collection of the Statens Museum for Kunst (Le Luxe II, 1907, Nude with White Scarf, c. 1909, and Bathers, c. 1909), one painting from the collection of The Metropolitan Museum of Art (Young Sailor II, 1906), a painting from a private collection (Cyclamen, c. 1911), and a glazed and hand-painted earthenware plate from the collection of the Museum of Modern Art (Untitled (Female Nude), 1907). The six paintings were investigated using technical (X-radiography, ultraviolet-induced fluorescence, infrared reflectography) and chemical imaging (MA-XRF) and, in some cases, spectroscopic techniques (FORS, SEM–EDS, Raman, SERS, and μ-FTIR), to better elucidate Matisse’s materials and working techniques for this selection of paintings; the plate was also analyzed using MA-XRF. New findings revealed the full extent to which Matisse had completed The Red Studio before applying its hallmark color, referred to as Venetian red in his correspondence, over the original palette of blue, pink, and ochre that dominated the composition. Particular attention was given to identifying the wide range of pigment choices made by Matisse in the execution of the works from 1906 and 1911 that are depicted in The Red Studio. These pigments include lead white, zinc white, bone black, earth reds, madder lake, carmine lake, vermilion, cadmium yellow, yellow ochre, aureolin (cobalt) yellow, orpiment, viridian green, chromium-oxide green, cobalt blue, ultramarine blue, Prussian blue, cobalt violet (deep and light), and other cobalt violets, as well as possibly manganese violet and eosin red lake. The results of these analyses allowed for a direct comparison between the original works and their depictions and revealed that Matisse, unsurprisingly given his strong association with color, often translated the pigment choices faithfully between the actual works and their depictions in The Red Studio.
Transfer learning: a friendly introduction
Authors: Hosna Asmaul , Merry Ethel , Gyalmo Jigmey , Alom Zulfikar , Aung Zeyar , Azim Mohammad Abdul 
Published: October 2022

AbstractInfinite numbers of real-world applications use Machine Learning (ML) techniques to develop potentially the best data available for the users. Transfer learning (TL), one of the categories under ML, has received much attention from the research communities in the past few years. Traditional ML algorithms perform under the assumption that a model uses limited data distribution to train and test samples. These conventional methods predict target tasks undemanding and are applied to small data distribution. However, this issue conceivably is resolved using TL. TL is acknowledged for its connectivity among the additional testing and training samples resulting in faster output with efficient results. This paper contributes to the domain and scope of TL, citing situational use based on their periods and a few of its applications. The paper provides an in-depth focus on the techniques; Inductive TL, Transductive TL, Unsupervised TL, which consists of sample selection, and domain adaptation, followed by contributions and future directions.
Evaluating the impact of price regulation (Drug Price Control Order 2013) on antibiotic sales in India: a quasi-experimental analysis, 2008–2018
Authors: Selvaraj Sakthivel , Farooqui Habib Hasan , Mehta Aashna , Mathur Manu Raj 
Published: October 2022

Abstract
Background
In India, due to a lack of population-level financial risk protection mechanisms, the expenditure on healthcare is primarily out-of-pocket in nature. Through Drug Price Control Orders (DPCOs), the Indian Government attempts to keep medicine prices under check. The aim of this study was to measure the potential impact of DPCO 2013 on the utilization of antibiotics under price regulation in India using large nationally representative pharmaceutical sales data.

Methods
We used interrupted time series analysis, a quasi-experimental research design to estimate the impact of DPCO 2013 on the utilization of antibiotics in the private sector in India. Indian pharmaceutical sales data set, PharmaTrac from a market research company—All Indian Origin Chemists and Distributors Limited—was used for the study. The data are collected from a panel of around 18,000 stockists across 23 different regions of the country. The primary outcome measure is the percentage change (increase or decrease) in the sales volume of the antibiotics under DPCO 2013, measured in standard units (SUs).

Results
Our estimates suggest that post-intervention (after notification of DPCO 2013) there was an immediate reduction (level change) in the sales of antibiotics under DPCO 2013 by 3.7% (P > 0.05), followed by a sustained decline (trend change) of 0.3% (P > 0.05) as compared to the pre-intervention trend at the molecule level, but both changes were statistically insignificant. However, in terms of ‘average monthly market share,’ the DPCO 2013 notification resulted in a sharp reduction of 579% (P < 0.05) (level change) followed by a sustained increase of 9.5% (P > 0.05) (trend change) in the ‘market share of antibiotics under DPCO’ as compared to pre-intervention trend.

Conclusions
The impact of DPCO 2013 in terms of the overall increase in the utilization of antibiotics under price regulation was limited but there was a switch from non-price controlled antibiotics to price regulated antibiotics (notified under DPCO 2013). We argue that policies on price control need to be complemented with continuous monitoring of market behavior to have a measurable and long-term impact.
Probabilistic tsunami hazard assessment based on the Gutenberg–Richter law in eastern Shikoku, Nankai subduction zone, Japan
Authors: Baba Toshitaka , Kamiya Masato , Tanaka Naoki , Sumida Yusuke , Yamanaka Ryoichi , Watanabe Kojiro , Fujiwara Hiroyuki 
Published: October 2022

AbstractEarthquake and tsunami predictions comprise huge uncertainties, thus necessitating probabilistic assessments for the design of defense facilities and urban planning. In recent years, computer development has advanced probabilistic tsunami hazard assessments (PTHAs), where hazard curves show the exceedance probability of the maximum tsunami height. However, owing to the lack of historical and geological tsunami records, this method is generally insufficient for validating the estimated hazard curves. The eastern coast of Shikoku in the Nankai subduction zone, Japan, is suitable for validation because tsunami records from historical Nankai Trough earthquakes are available. This study evaluated PTHAs by comparing the tsunami hazard curves and exceedance frequencies of historical Nankai Trough tsunamis. We considered 3480 earthquake scenarios representing the rupture patterns of past Nankai earthquakes and calculated all tsunamis. The probability of earthquake occurrence was based on the Gutenberg–Richter law. We considered uncertainty in tsunami calculations with astronomical tide variations. The estimated tsunami hazard curves are consistent with the exceedance frequencies obtained from historical tsunamis. In addition, sensitivity tests indicate the significance of the earthquake slip heterogeneity and tsunami defense facilities in PTHAs. We also extended the PTHAs to tsunami inundation maps in high resolution and proposed an effective new method for reducing the tsunami computation load.
Graphical Abstract
Hemodynamic management of acute brain injury caused by cerebrovascular diseases: a survey of the European Society of Intensive Care Medicine
Authors: Messina Antonio , Villa Federico , Lionetti Giulia , Galarza Laura , Meyfroidt Geert , van der Jagt Mathieu , Monnet Xavier , Pelosi Paolo , Cecconi Maurizio , Robba Chiara 
Published: October 2022

Abstract
Background
The optimal hemodynamic targets and management of patients with acute brain injury are not completely elucidated, but recent evidence points to important impact on clinical outcomes. We performed an international survey with the aim to investigate the practice in the hemodynamic targets, monitoring, and management of patients with acute ischemic stroke (AIS), intracranial hemorrhage (ICH) and subarachnoid hemorrhage (SAH).

Methods
This survey was endorsed by the European Society of Intensive Care (ESICM). An electronic questionnaire of 76 questions divided in 4 sections (general information, AIS, ICH, SAH specific questions) was available between January 2022 to March 2022 on the ESICM website.

Results
One hundred fifty-four healthcare professionals from 36 different countries and at least 98 different institutions answered the survey. Routine echocardiography is routinely performed in 37% of responders in AIS, 34% in ICH and 38% in SAH. Cardiac output monitoring is used in less than 20% of cases by most of the responders. Cardiovascular complications are the main reason for using advanced hemodynamic monitoring, and norepinephrine is the most common drug used to increase arterial blood pressure. Most responders target fluid balance to neutral (62% in AIS, 59% in ICH,44% in SAH), and normal saline is the most common fluid used. Large variability was observed regarding the blood pressure targets.

Conclusions
Hemodynamic management and treatment in patients with acute brain injury from cerebrovascular diseases vary largely in clinical practice. Further research is required to provide clear guidelines to physicians for the hemodynamic optimization of this group of patients.
Spatiotemporal vertical velocity variation in the western tropical Pacific and its relation to decadal ocean variability
Authors: Nagano Akira , Hasegawa Takuya , Wakita Masahide 
Published: October 2022

Abstract
Prior to the cold phase of the Pacific decadal oscillation (PDO), sea surface water in the western tropical North Pacific is heated. To evaluate the impact of the subsurface water on the upper-ocean ($$<100$$

<
100

m depth) temperature variation, we examined the vertical velocity variation. We applied altimetry-based gravest empirical mode (AGEM) method to Argo hydrographic profile (2001–2017) and altimetric sea surface height (1993–2017) data in the western tropical Pacific and obtained a time-varying three-dimensional (3D) potential density field in the layer from 100 to 1000 m depth. From the AGEM-derived potential density, we derived a 3D field of vertical velocity below 100 m depth by the P-vector inverse method, which is based on potential density and vorticity conservations, and examined the spatiotemporal characteristics, focusing on the seasonal to quasi-decadal (QD) variations. In the mean state, substantial upward current ($$>10^{-6}\,{\text {m\,s}}^{-1}$$

>

10

-
6

m\,s

-
1

) is observed in the region of $$10^{\circ }$$

10
∘

–$$17^{\circ }$$

17
∘

N, $$140^{\circ }$$

140
∘

E–$$180^{\circ }$$

180
∘

in the North Equatorial Current, southern part of the North Pacific subtropical gyre. Possibly besides the Ekman upwelling, the upward current contributes to the cooling of the upper ocean in the western tropical North Pacific through the upward advection of the deep cold water. The upward current was found to be intensified (attenuated) by the strengthening (weakening) of the subtropical gyre interior southward flow on the QD timescale in association with frequent occurrences of La Niña (El Niño) events. The weakening of the upward current is responsible for the QD increase in upper-ocean temperature in the western tropical North Pacific, which is equivalent to or larger than $$0.2~^{\circ }$$

0.2

∘

C, several years after the warm phase of the PDO. The QD temperature variation may affect the phase reversal of the PDO through the heat transport of the western boundary current of the subtropical gyre, i.e., the Kuroshio.
Antenatal preventative pelvic floor muscle exercise intervention led by midwives to reduce postnatal urinary incontinence (APPEAL): protocol for a feasibility and pilot cluster randomised controlled trial
Authors: Bick D. , Bishop J. , Coleman T. , Dean S. , Edwards E. , Frawley H. , Gkini E. , Hay-Smith J. , Hemming K. , Jones E. , Oborn E. , Pearson M. , Salmon V. , Webb S. , MacArthur C. 
Published: October 2022

Abstract
Background
Antenatal pelvic floor muscle exercises (PFME) in women without prior urinary incontinence (UI) are effective in reducing postnatal UI; however, UK midwives often do not provide advice and information to women on undertaking PFME, with evidence that among women who do receive advice, many do not perform PFME.

Methods
The primary aim of this feasibility and pilot cluster randomised controlled trial is to provide a potential assessment of the feasibility of undertaking a future definitive trial of a midwifery-led antenatal intervention to support women to perform PFME in pregnancy and reduce UI postnatally.
Community midwifery teams in participating NHS sites comprise trial clusters (n = 17). Midwives in teams randomised to the intervention will be trained on how to teach PFME to women and how to support them in undertaking PFME in pregnancy. Women whose community midwifery teams are allocated to control will receive standard antenatal care only.
All pregnant women who give birth over a pre-selected sample month who receive antenatal care from participating community midwifery teams (clusters) will be sent a questionnaire at 10–12 weeks postpartum (around 1400–1500 women). Process evaluation data will include interviews with midwives to assess if the intervention could be implemented as planned. Interviews with women in both trial arms will explore their experiences of support from midwives to perform PFME during pregnancy. Data will be stored securely at the Universities of Birmingham and Exeter.
Results will be disseminated through publications aimed at maternity service users, clinicians, and academics and inform a potential definitive trial of effectiveness. The West Midlands–Edgbaston Research Ethics Committee approved the study protocol.

Discussion
Trial outcomes will determine if criteria to progress to a definitive cluster trial are met. These include women’s questionnaire return rates, prevalence of UI, and other health outcomes as reported by women at 10–12 weeks postpartum. Progress to a definitive trial however is likely to be prevented in the UK context by new perinatal pelvic health service, although this may be possible elsewhere.

Trial registration
https://doi.org/10.1186/ISRCTN10833250. Registered 09/03/2020
Clinical feasibility and preliminary outcomes of a novel mixed reality system to manage phantom pain: a pilot study
Authors: Annaswamy Thiru M , Bahirat Kanchan , Raval Gargi , Chung Yu Yen , Pham Tri , Prabhakaran Balakrishnan 
Published: October 2022

Abstract
Background
To assess the clinical feasibility of a virtual mirror therapy system in a pilot sample of patients with phantom pain.

Methods
Our Mixed reality system for Managing Phantom Pain (Mr. MAPP) mirrors the preserved limb to visualize the amputated limb virtually and perform exercises. Seven patients with limb loss and phantom pain agreed to participate and received the system for 1-month home use. Outcome measures were collected at baseline and 1 month.

Results
Four (of seven recruited) participants completed the study, which was temporarily suspended due to COVID-19 restrictions. At 1 month, in-game data showed a positive trend, but pain scores showed no clear trends. Functioning scores improved for 1 participant.

Conclusions
Mr. MAPP is feasible and has the potential to improve pain and function in patients with phantom pain.

Trial registration
Clinical Trials Registration, NCT04529083
Targeted thrombolysis by magnetoacoustic particles in photothrombotic stroke model
Authors: Choi Wonseok , Cho Hyeyoun , Kim Gahee , Youn Inchan , Key Jaehong , Han Sungmin 
Published: October 2022

Abstract

Background

Recombinant tissue plasminogen activator (rtPA) has a short half-life, and additional hemorrhagic transformation (HT) can occur when treatment is delayed. Here, we report the design and thrombolytic performance of 3

μ

m discoidal polymeric particles loaded with rtPA and superparamagnetic iron oxide nanoparticles (SPIONs), referred to as rmDPPs, to address the HT issues of rtPA.

Methods

The rmDPPs consisted of a biodegradable polymeric matrix, rtPA, and SPIONs and were synthesized
via
a top-down fabrication.

Results

The rmDPPs could be concentrated at the target site with magnetic attraction, and then the rtPA could be released under acoustic stimulus. Therefore, we named that the particles had magnetoacoustic properties. For the
in vitro
blood clot lysis, the rmDPPs with magnetoacoustic stimuli could not enhance the lytic potential compared to the rmDPPs without stimulation. Furthermore, although the reduction of the infarcts
in vivo
was observed along with the magnetoacoustic stimuli in the rmDPPs, more enhancement was not achieved in comparison with the rtPA. A notable advantage of rmDPPs was shown in delayed administration of rmDPPs at poststroke. The late treatment of rmDPPs with magnetoacoustic stimuli could reduce the infarcts and lead to no additional HT issues, while rtPA alone could not show any favorable prognosis.

Conclusion
The rmDPPs may be advantageous in delayed treatment of thrombotic patients.