bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generalized discrete‐time equivalent model for interfacing the grid‐connected photovoltaic system
Authors: Shen Fu , Zhang Yutao , Qiu Gefei , Yang Zhiwen , Li Shiwei , Yang Guangbing 
Published: November 2022

AbstractThe power system dynamics have consistently challenged the rapid and persistent proliferation of photovoltaic (PV) systems in power systems. In this paper, the authors propose the generalized discrete‐time equivalent model (GDEM) of PV power generation system using a fourth‐order dynamic equivalent model for representing the physical characteristics of PV power stations in power system dynamic studies. In addition, the authors propose a grid‐connected system model which includes modelling interfaces (MIs) for the GDEM of power grid and the GDEM of PV power generation system in dynamic studies. The proposed equivalent models of the power grid and PV power generation system will improve the simulation accuracy and speed in dynamic power system studies. The authors have used the IEEE 14‐bus system and simulated various types of short‐circuit faults and PV penetration levels in their study to demonstrate the merits of the proposed GDEM of grid‐connected system in power systems. The pertinent simulation results are analyzed and conclusions are presented.
Abklärung und Behandlung des benignen paroxysmalen Lagerungsschwindels mittels manueller und motorisierter Drehstühle
Authors: Tarnutzer Alexander Andrea 
Published: November 2022

ZUSAMMENFASSUNGDer benigne paroyxsmale Lagerungsschwindel (BPLS) ist die häufigste Ursache eines episodischen Schwindels. Während die Diagnose anhand einer gezielten Anamneseerhebung und anschließender Provokationsmanöver auf der Untersucherliege meist zuverlässig gestellt und die Behandlung eingeleitet werden kann, können diese Manöver bei Patienten mit bestimmten Vorerkrankungen (z. B. des Bewegungsapparates oder Nervensystems) nicht oder nur eingeschränkt durchgeführt werden. Gleichzeitig zeigt sich ein Teil der Patienten mit BPLS therapierefraktär. Die Verwendung eines manuellen oder motorisierten Drehstuhls erweitert sowohl die diagnostischen wie auch die therapeutischen Möglichkeiten beim BPLS. So ermöglicht sie einzelnen Patientengruppen aufgrund von Vorerkrankungen eine gezielte Abklärung bei entsprechendem Verdacht und, sofern erforderlich, eine evidenzbasierte Behandlung. Ebenso erweitert der Drehstuhl das Abklärungsspektrum und die Auswahl an Repositionsmanövern in unklaren oder therapierefraktären Fällen. In diesem Übersichtsartikel werden potenzielle Indikationen beschrieben und die Evidenz für die Abklärung und Behandlung des BPLS auf einem Drehstuhl diskutiert.
Sturzprävention im Alltag
Authors: Basta Dietmar , Ernst Arne 
Published: November 2022

ZUSAMMENFASSUNGStürze im Alltag treten mit zunehmendem Alter viel häufiger auf und deren Folgen sind oft schwerwiegender. Die Sturzgefahr ist jedoch besonders im Alter sehr heterogen verteilt. Somit ist die individuelle Beurteilung des Sturzrisikos eine grundlegende Aufgabe der Sturzprävention. Die Erfassung des individuellen Sturzrisikos ist noch sehr subjektiv und hat eine geringe Sensitivität und Spezifität. Dabei sind seit längerer Zeit objektive Verfahren mit einer hohen diagnostischen Güte verfügbar.Auf Basis der individuellen Ermittlung des Sturzrisikos sollte das weitere Vorgehen bei der Sturzprävention entschieden werden. Ein zentraler Punkt ist dabei das Gleichgewichtstraining. Dieses sollte besonders in der Hauptzielgruppe, den älteren Patienten, sehr effektiv und somit wenig körperlich anspruchsvoll gestaltet sein. Aktuell erfüllen individualisierte Trainingsansätze unter Verwendung von sensorischem Feedback, insbesondere vibrotaktilem Feedback, diese Kriterien. Der Langzeiterfolg jeglicher Trainingsansätze hängt jedoch davon ab, wie gut der Patient durch das Training mobilisiert werden konnte und Bewegung wieder in den Alltag integriert.
Trio im Fokus
Authors: Lang Eva 
Published: November 2022

SummaryIn der Klassischen Homöopathie werden auch Pilze eingesetzt, 3 Beispiele sind Fliegenpilz, Staubpilz und Mutterkorn. Einige Themen sind bei Pilzmitteln in der Klassischen Homöopathie besonders im Fokus, zum Beispiel das zentrale Nervensystem. In diesem Beitrag werden die 3 vorgestellten homöopathischen Pilzmittel durch ihre Symptome und ein Fallbeispiel aufgegriffen.
Effects of High-Fructose Corn Syrup Intake on Glucocorticoid
Metabolism in Rats During Childhood, Adolescence and Adulthood
Authors: Nouchi Yuki , Munetsuna Eiji , Yamada Hiroya , Yamazaki Mirai , Ando Yoshitaka , Mizuno Genki , Fujii Ryosuke , Kageyama Itsuki , Wakasugi Takuya , Sakakibara Tomohide , Teshigawara Atsushi , Ishikawa Hiroaki , Shimono Yohei , Suzuki Koji , Hashimoto Shuji , Ohashi Koji 
Published: November 2022

AbstractThe consumption of high-fructose corn syrup (HFCS) has been increasing in recent
decades, especially among children. Some reports suggest that children and
adolescents are more sensitive to the adverse effects of fructose intake than
adults. However, the underlying mechanism of the difference in vulnerability
between adolescence and adulthood have not yet been elucidated. In this study,
we attempted to elucidate the different effects of HFCS intake at different
growth stages in rats: childhood and adolescence (postnatal day (PD)
21–60), young adulthood (PD60–100), and adulthood
(PD100–140). Since alterations in hepatic glucocorticoid (GC) metabolism
can cause diseases including insulin resistance, we focused on GC metabolizing
enzymes such as 11 beta-hydroxysteroid dehydrogenase 1 and 2 (Hsd11b1 and
Hsd11b2) and steroid 5 alpha-reductase 1 (Srd5a1). Western blotting showed an
increase in Hsd11b1 expression and a decrease in Hsd11b2 expression in childhood
and adolescence but not in adulthood. We also observed changes in Hsd11b1 and
Hsd11b2 activities only in childhood and adolescence, consistent with the
results of mRNA and protein expression analysis. The effect of high-fructose
intake with regards to GC metabolism may therefore vary with developmental
stage. This study provides insight into the adverse effects of fructose on GC
metabolism in children in the context of increasing rates of HFCS
consumption.
Nährstoffquelle mit Wermutstropfen
Authors: März Henrike 
Published: November 2022

SummaryWeil sie meist in Symbiose mit Bäumen leben, lassen sich Pilze nur sehr bedingt kultivieren und unterteilen sich in wenige Kultur- und viele Wildarten. Obwohl Pilze unter anderem aufgrund ihres Chitinanteils eher schwer verdaulich sind, eignen sie sich in Maßen hervorragend als vielseitige und kalorienarme Nahrungs- und Gewürzbeigabe und Quelle für B-Vitamine, Vitamin D sowie essenzielle Fett- und Aminosäuren. Als Bioakkumulatoren speichern Pilze neben Nährstoffen auch Schadstoffe wie Schwermetalle und verderben zudem schnell, sodass für das Sammeln und Zubereiten einige Regeln zu beachten sind.
Laissez-faire Technique in Periocular Reconstructive Surgery following Tumour Resection
Authors: Linntam Delis , Klett Artur 
Published: November 2022

AbstractThe laissez-faire technique, although not widely used by oculoplastic surgeons, is a valuable option in the reconstruction of periocular defects following tumour resection. In the authorsʼ
experience, the most suitable location is the medial canthal area. Primary surgery is often simpler and better tolerated by the patient compared with alternative, more complex surgical
procedures. The final functional and cosmetic outcome is highly dependent on patient selection and for an excellent result, certain modifications in surgical technique and additional
manipulations in the early postoperative period must be considered. The technique is not usually the first choice, due to fear of a prolonged and complicated wound healing period. The
unpredictability of the results may also be of concern to oculoplastic surgeons. This case series illustrates some modifications of surgery and postoperative care that can help optimise the
outcome and reduce postoperative complications. As wound healing and scarring are influenced by contraction in the wound bed, tension guiding sutures are a valuable adjunct to laissez-faire
techniques. They improve the predictability of the result after healing, and this is important primarily in reducing the risk of cicatricial ectropium, but also in the cosmetic result.
Although there is a risk of infection with any open wound, in general, thorough patient education usually suffices to avoid postoperative complications. Appropriate wound care in the
laissez-faire technique is fairly simple and easily achievable.
Tinea: Von Kopf bis Fuß
Authors: Schmid Eva C. 
Published: November 2022

SummaryAls Tinea bezeichnet man eine Infektion mit Dermatophyten – Fadenpilzen, die vorwiegend Haut, Nägel und Haare befallen und den Gattungen Trichophyton, Microsporum und Epidermophyton zugerechnet werden. Infektionen können alle Hautareale betreffen, breiten sich aber besonders gut an feuchten und warmen Stellen aus – häufig zeigen sich Pusteln, Papeln oder typisch runde, abgegrenzte Herde. Zu den wichtigsten Differenzialdiagnosen zählen allergisches und atopisches Ekzem, Candidose, Autoimmunerkrankungen, Reizzustände und bakterielle Infektionen.
Von A wie Agaricus bis X wie Xerocomus
Authors: Jahn Claus 
Published: November 2022

SummaryPilzmittel können neben ihrem Einsatz in der Klassischen Homöopathie (siehe S. 34) auch indikationsbezogen verordnet werden, teilweise synergistisch als Komplexmittel. Die Anwendungsgebiete sind sehr vielfältig und reichen je nach Pilzmittel von Mykosen (siehe S. 50, 57) über gastrointestinale Beschwerden bis hin zu neurologischen Störungen. Manche Pilze sind aufgrund ihrer Toxizität als Homöopathikum erst ab einer bestimmten Potenz einsetzbar. So wird zum Beispiel der hochgiftige Grüne Knollenblätterpilz – erlaubt ab einer D6 – zu einem effektiven homöopathischen Lebermittel.
Saliva Sampling in Therapeutic Drug Monitoring and Physiologically
Based Pharmacokinetic Modeling: Review
Authors: Almukainzi May 
Published: November 2022

AbstractTherapeutic drug monitoring investigations based on saliva samples can be
utilized as an alternative to blood sampling for many advantages. Moreover, the
development of physiologically based pharmacokinetic (PBPK) modeling tools can
further help to estimate drug exposure from saliva. This review discusses the
use of saliva samples and illustrates the applications and examples of PBPK
modeling systems for estimating drug exposure from saliva.
A Double-blind, Placebo-controlled, Randomized, Single Ascending, and
Multiple Dose Phase 1 Study to Evaluate the Safety, Tolerability, and
Pharmacokinetics of Oral Dose Isomyosamine Capsules in Healthy Adult
Subjects
Authors: Brager Jenna , Chapman Chris , Dunn Leonard , Kaplin Adam 
Published: November 2022

Abstract
Background Aging is tightly linked to chronic disease, frailty, and death.
Multi-morbidity, defined as the presence in the same patient of three or more
conditions such as neoplastic, cardiovascular, neurodegenerative, metabolic, or
autoimmune diseases, becomes more common with age.
Methods The study was performed in a double-blind fashion. Subjects within
each dose cohort (Cohorts 1, 2, 3, and 4) were randomly assigned to receive
Isomyosamine doses (between 150 mg to 600 mg or placebo) or
placebo in a 3:1 ratio (6 active: 2 placebo).
Results Isomyosamine single daily doses each of 150 mg,
300 mg, and 450 mg for 3 days and multiple daily doses of
600 mg for 6 days were safe and well tolerated in healthy subjects. In
one dose group, there was a decrease in TNF-α levels found in
Isomyosamine treated subjects, but no change in the levels in subjects given
placebo. The increase in Isomyosamine exposure was proportional to dose across
the dose range of 300 mg to 600 mg when administered as a single
dose. There was minimal accumulation of Isomyosamine following 5 days of once
daily dosing of Isomyosamine 600 mg. Isomyosamine half-life ranged from
approximately 15 minutes to 45 minutes across all doses in the
single ascending dose and multiple ascending dose portion of the study.
Elimination of Isomyosamine included the renal pathway as a minor route.
Conclusion Isomyosamine will continue to be investigated in phase 2
clinical trials for the treatment of sarcopenia/frailty,
hashimoto’s thyroiditis and rheumatoid arthritis.
Stereo- and Regioselective Synthesis of (E,E)-Dienes: Evolution from the Transition-Metal-Catalyzed Cross-Coupling to Titanium Alkoxide-Based Alkyne–Alkyne Reductive Coupling
Authors: Wu Jie , Panek James S. , Cai Bin , Toh Ren Wei , Ang Hwee Ting 
Published: November 2022

AbstractThe pursuit of step- and atom-economy in natural product and complex molecule syntheses continuously inspires the development of synthetic methodologies. In this context, to enable efficient synthesis of (E,E)-dienes as common structural subunits in natural products, our lab has established robust protocols based on modified Negishi cross-couplings and evolved them to more concise titanium-mediated alkyne–alkyne reductive coupling. In this review, we summarize the natural product synthesis driven methodology development and their applications in the total synthesis of complex molecules, focusing on the studies from our laboratory.1	Introduction2	Transition-Metal-Catalyzed Cross-Coupling in Natural Product Synthesis2.1	Synthesis of Branched Trisubstituted Conjugated Dienes by Negishi Coupling2.2	Stereo- and Regiocontrolled Synthesis of Branched Trisubstituted Conjugated Dienes by Modified Negishi Coupling2.3	Enantioselective Total Synthesis of Reveromycin B by Drouet & Theodorakis2.4	Enantioselective Synthesis of the Protein Phosphatase Inhibitor (–)-Motuporin by Hu & Panek2.5	Total Synthesis of (–)-Callystatin A by Langille & Panek2.6	Total Synthesis of Brevisamide by Lee & Panek3	Titanium Alkoxide-Mediated Reductive Coupling in Natural Product Synthesis3.1	Titanium Alkoxide-Mediated Alkyne–Alkyne Reductive Coupling3.2	Total Synthesis of Callystatin A by Reichard & Micalizio3.3	Total Synthesis of (–)-Virginiamycin M2 by Wu & Panek3.4	Total Synthesis of Nuclear Factor of Activated T-Cells-68 (NFAT-68) by Cai & Panek3.5	Titanium Alkoxide-Based Regioselective Alkyne–Alkyne Reductive Coupling Mediated by in situ Generated Arylamidate4	Summary
Protective Effects of Lactobacillus reuteri on Intestinal Barrier Function in a Mouse Model of Neonatal Necrotizing Enterocolitis
Authors: Lai Zhuoli , Gong Fang 
Published: November 2022

Objective The intestinal mucosal and immune barriers play considerable roles in the pathogenesis of necrotizing enterocolitis (NEC). The present research was designed to assess the protective effects of Lactobacillus reuteri (LR) DSM 17938 (LR 17938) on the intestinal barriers and its beneficial effects on inflammation in a neonatal mouse model of NEC.
Study Design Overall, 7-day-old 75 C57BL/6 neonatal mice were separated into three groups (n = 25) as follows: (1) control, (2) NEC, and (3) NEC + LR17938 (LR group). NEC mice were administered a hypertonic feeding formula and subjected to asphyxia and hypothermia. Hematoxylin and eosin (HE) staining and pathological scores were used to assess the pathological changes in the intestine. Oxidative stress was evaluated based on the levels of superoxide dismutase (SOD) and malondialdehyde (MDA). Tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels were detected to assess inflammation. Gut permeability levels, bacterial translocation, and the levels of secretory idioglobulin A (sIgA), β-defensin, and tight junction (TJ) proteins were detected to evaluate gut mucosal and immune barrier function, and gut microbial diversity was detected to assess the composition of the gut flora.
Results LR 17938 administration decreased the NEC-induced increase in intestinal scores, mortality rate, gut damage, the MDA level, and TNF-α and IL-1β expressions. Besides, LR 17938 improved the survival rate of NEC mice. Moreover, LR 17938 administration improved gut permeability levels, SOD activity and the bacterial translocation, ameliorated the expression of TJ proteins, and improved the gut microbiota compared with those of NEC mice.
Conclusion LR 17938 reduced intestinal inflammation and played a protective role in a neonatal animal model of NEC, possibly by regulating oxidative stress and exerting a protective effect on the gut mucosal and immune barriers.
Key Points
New Horizons in Fetal and Neonatal Alloimmune Thrombocytopenia
Authors: Barg Assaf , Bonstein Lilach 
Published: November 2022

AbstractFetal and neonatal alloimmune thrombocytopenia (FNAIT) is a common cause of severe thrombocytopenia in newborns. Intracranial bleeding may lead to severe neurological sequelae and mortality. Current management of pregnancies at risk is suboptimal. Prenatal FNAIT diagnosis commonly requires invasive procedures and therapy is associated with a high treatment burden. The present review explores advances in the field and their potential contribution to modification of the diagnostic and therapeutic landscape. Topics addressed include the role of noninvasive prenatal testing using fetal cell free DNA, insights into novel and prospective therapeutic options achieved through the development of murine models of FNAIT as well as the forecast for the progress in pregnancy risk stratification through advancement in the investigation of biological characteristics of alloantibodies and their association with the risk of fetal bleeding.
A Novel Strategy for the Mechanical Subpulmonary Support in Failing Fontan Patients
Authors: Dal Sasso Eleonora , Schöndorf Thomas , Schlüter Kim-John , Miera Oliver , De Rita Fabrizio , Menon Ares K. ,   on behalf of the European EXCOR® Pediatric Investigator Group (EEPIG)
Published: November 2022

Abstract
Background The number of single ventricle patients undergoing Fontan palliation and surviving to adulthood worldwide has steadily increased in recent years. Nevertheless, the Fontan circulation is destined to fail. Ultimately, heart transplantation (HTx) remains the definitive treatment option. Due a shortage of organs, mechanical circulatory support in the form of ventricular assist devices (VADs) is widely used to bridge heart failure patients to HTx, but these devices have been mainly developed to address the needs of normal anatomies. A novel venous cannula has been developed as part of the EXCOR® VAD to provide subpulmonary support in these patients. Its clinical application is investigated in the “Registry to Assess the Safety and Feasibility of the Subpulmonary Support with the Novel Venous Cannula in Patients with Failing/Absence of the Right Heart” (RegiVe study, NCT04782232).
Methods RegiVe is a multicenter, international, observational, prospective, non-randomized registry aiming to collect the routine clinical data of up to 20 patients. The primary endpoints address device performance and safety, while the secondary endpoints target organ status and overall safety (according to the Interagency Registry for Mechanically Assisted Circulatory Support – INTERMACS – definitions). Data analysis will be performed by means of descriptive statistics.
Results RegiVe has received the favorable opinion of an independent ethics committee and enrollment has recently started.
Conclusion RegiVe is the first study evaluating the use of a medical device specifically developed for subpulmonary support of failing Fontan patients. The study will provide important insight and further information on this cohort and help to improve a dedicated VAD strategy.
The ART of Thromboprophylaxis in the Prevention of Gestational Venous Thromboembolism
Authors: Grandone Elvira , Barcellona Doris , Intrieri Mariano , Tiscia Giovanni , Nappi Luigi , Othman Maha 
Published: November 2022

AbstractAssisted reproductive techniques (ART) allow infertile couples to conceive. Use of hormones to obtain a controlled ovarian stimulation and an adequate growth of the endometrium preparatory for embryo implantation are not riskless. Among others, thrombotic events can occur during the ovulation induction or pregnancy following ART. As the number of women approaching ART to conceive is steadily increasing, the issue of thrombotic risk in this setting is relevant. Data on the weight of each risk factor and on potential benefit of thromboprophylaxis are largely lacking. In this review, we discuss risk of venous thromboembolism during pregnancy following ART, with a focus on general (i.e.: age, body mass index, thrombophilia, bed rest, transfusions) and ART-specific (i.e., polycystic ovarian syndrome, ovarian hyperstimulation syndrome) risk factors. We also attempt to provide some suggestions to guide clinical practice, based on available data and studies performed outside ART.
Planning Pregnancy and Birth in Women with Inherited Bleeding Disorders
Authors: Malinowski A. Kinga , Abdul-Kadir Rezan 
Published: November 2022

AbstractInherited bleeding disorders are characterized by a diverse clinical phenotype within and across specific diagnoses. von Willebrand disease (VWD), hemophilia A, and hemophilia B comprise 95 to 97% of inherited bleeding disorders, with the remaining 3 to 5% attributed to rare bleeding disorders, including congenital fibrinogen disorders, factor deficiencies (affecting FII, FV, FV + FVIII, FVII, FX, FXI, and FXIII), and platelet function defects. The pregnancy, birth, and the puerperium may be adversely influenced in the setting of an inherited bleeding disorder depending on its type and clinical phenotype. Obstetric hemostatic challenges may sometimes also unmask the presence of a previously unknown inherited bleeding disorder. This review aims to address the approach to pregnancy and birth in the context of an inherited bleeding disorder and highlights the significance of multidisciplinary input into the care of these women.
Early Results of Total Coronary Revascularization via Left Anterior Thoracotomy
Authors: Sellin Christian , Asch Silke , Belmenai Ahmed , Mourad Fanar , Voss Meinolf , Dörge Hilmar 
Published: November 2022

Abstract
Background Avoidance of sternotomy while preserving complete revascularization remains challenging in multivessel coronary disease. Technical issues and in-hospital outcomes of total coronary revascularization via a small left anterior thoracotomy (TCRAT) in nonselected patients with multivessel disease are reported.
Methods From November 2019 to September 2021, coronary artery bypass grafting via left anterior minithoracotomy on cardiopulmonary bypass and cardioplegic cardiac arrest was performed in 102 patients (92 males; 67 ± 10 [42–87] years). Slings were placed around ascending aorta, left pulmonary veins, and inferior vena cava for exposure of lateral and inferior ventricular wall. All patients had multivessel coronary disease (three-vessel disease: n = 72; two-vessel disease: n = 30; left main stenosis: n = 44). We included patients at old age (> 80 years, 14.7%), with severe left ventricular dysfunction (ejection fraction < 30%, 6.9%), massive obesity (body mass index > 35, 11.6%), and at increased risk (EuroSCORE II > 4, 15.7%).
Results Left internal thoracic artery (n = 101), radial artery (n = 83), and saphenous vein (n = 39) grafts were used for total (61.8%) or multiple (19.6%) arterial grafting. A total of 323 distal anastomoses (3.2 ± 0.7 [2–5] per patient) were performed to revascularize left anterior descending (100%), circumflex (91.2%), and right coronary artery (67.7%). Complete revascularization was achieved in 95.1%. In-hospital mortality was 2.9%, stroke rate was 1.0%, myocardial infarction rate was 2.9%, and repeat revascularization rate was 2.0%.
Conclusion This novel surgical technique allows complete coronary revascularization in the broad majority of multivessel disease patients without sternotomy. TCRAT can be introduced into clinical routine safely. Long-term results remain to be investigated.