bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS GAYA KEPEMIMPINAN KEPALA UPTD DALAM MENINGKATKAN DISIPLIN KERJA PEGAWAI DI UPTD PENDIDIKAN KECAMATAN SUMBERJAYA KABUPATEN MAJALENGKA
Authors: Ramadhan Deli Faisal , Agustina Heriyani , Siraj Nurudin 
Published: July 2022

Abstrak Pola tingkah laku pegawai merupakan dampak dari seorang pemimpin, maka dari itu diduga penerapan gaya kepemimpinan Kepala UPTD berdampak pada kedisiplinan pegawai yang masih belum sesuai dengan situasi dan kondisi kerja pegawai. Gaya kepemimpinan Kepala UPTD yang masih belum optimal dirasa berpengaruh terhadap disiplin kerja pegawai, karena dapat menghambat pada kepentingan pelaksanaan tugas, pelaksanaan hubungan kerjasama, dan pada kepentingan hasil yang dicapai dalam organisasi. Penelitian ini bertujuan untuk mengetahui secara langsung dalam penerapan gaya kepemimpinan Kepala UPTD dalam meningkatkan disiplin kerja pegawai, untuk mengetahui faktor penghambat kedisiplinan pegawai dan untuk mengetahui faktor pendukung kedisiplinan pegawai UPTD Pendidikan Kecamatan Sumberjaya Kabupaten Majalengka. Penelitian dilakukan dengan menggunakan metode penelitian kualitatif, metode ini menggunakan teknik pengumpulan data: studi kepustakaan, wawancara, observasi, dokumentasi. Penelitian dilakukan di UPTD Pendidikan Kecamatan Sumberjaya Kabupaten Majalengka, dengan informan Kepala UPTD dan beberapapegawai. Hasil penelitian: 1) Penerapan gaya kepemimpinan Kepala UPTD Pendidikan Kecamatan Sumberjaya yang bertipe kepemimpinan paternalistik belum optimal dengan situasi dan kondisi sehingga menyebabkan dampak yang kurang baik bagi disiplin kerja pegawai, 2) Faktor penghambat kedisiplinan pegawai UPTD Pendidikan Kecamatan Sumberjaya yang disebabkan dari pemimpinnya yang kurang menindaklanjuti dalam menegaskan peraturan yang ada, dan 3) Faktor pendukung kedisiplinan pegawai UPTD Pendidikan Kecamatan Sumberjaya terdapat peraturan tata tertib kantor dan peraturan pemerintah tentang disiplin PNS sebagai pedoman dalam bekerja.
The Implicature of Reddit Memes from r/HistoryMemes Sub-Reddit
Authors: Pramesthi Nadia Agatha 
Published: July 2022

Memes have been a media of entertainment when the internet has been a part of human’s life. Reddit as a source of a community who shares anything from news, information, gossip, to memes, is the core of this research. Fifty memes taken from a subreddit called r/HistoryMemes became the object of the research. The question is, do the memes exclusively enjoyed by the community or do the memes can also be brought outside the community and people still understand the joke? Using the Implicature theory, the researcher tries to answer the question. The result is that there is a possibility for the people outside the community of r/HistoryMemes subreddit to understand the joke that is delivered by the meme
Patterns of Convergence and Divergence Between Bipolar Disorder Type I and Type II: Evidence From Integrative Genomic Analyses
Authors: Huang Yunqi , Liu Yunjia , Wu Yulu , Tang Yiguo , Zhang Mengting , Liu Siyi , Xiao Liling , Tao Shiwan , Xie Min , Dai Minhan , Li Mingli , Gui Hongsheng , Wang Qiang 
Published: July 2022

Aim: Genome-wide association studies (GWAS) analyses have revealed genetic evidence of bipolar disorder (BD), but little is known about the genetic structure of BD subtypes. We aimed to investigate the genetic overlap and distinction of bipolar type I (BD I) &amp; type II (BD II) by conducting integrative post-GWAS analyses.Methods: We utilized single nucleotide polymorphism (SNP)–level approaches to uncover correlated and distinct genetic loci. Transcriptome-wide association analyses (TWAS) were then approached to pinpoint functional genes expressed in specific brain tissues and blood. Next, we performed cross-phenotype analysis, including exploring the potential causal associations between two BD subtypes and lithium responses and comparing the difference in genetic structures among four different psychiatric traits.Results: SNP-level evidence revealed three genomic loci, SLC25A17, ZNF184, and RPL10AP3, shared by BD I and II, and one locus (MAD1L1) and significant gene sets involved in calcium channel activity, neural and synapsed signals that distinguished two subtypes. TWAS data implicated different genes affecting BD I and II through expression in specific brain regions (nucleus accumbens for BD I). Cross-phenotype analyses indicated that BD I and II share continuous genetic structures with schizophrenia and major depressive disorder, which help fill the gaps left by the dichotomy of mental disorders.Conclusion: These combined evidences illustrate genetic convergence and divergence between BD I and II and provide an underlying biological and trans-diagnostic insight into major psychiatric disorders.
Chemical Constituents With Antiproliferative Activity From Pogostemon cablin (Blanco) Benth.
Authors: Peng Xingjia , Ang Song , Zhang Yizi , Fan Fenling , Wu Mengshuo , Liang Peiting , Wen Yan , Gan Lishe , Zhang Kun , Li Dongli , Yue Jianmin 
Published: July 2022

Two new patchoulene sesquiterpenoid glycosides (1–2), a natural patchoulane-type sesquiterpenoid (3) and a natural cadinene-type sesquiterpenoid (4), were isolated from the aerial parts of Pogostemon cablin (Blanco) Benth., together with eleven known sesquiterpenoids (5–15) and eleven known flavonoids (16–26). Their chemical structures were elucidated on the basis of spectroscopic methods, including NMR, HRESIMS, IR, and CD spectroscopic data analysis, as well as chemical hydrolysis. The isolated compounds 1–13 and 15–26 were tested for inhibitory effects on the proliferation of HepG2 cancer cells. Among them, compounds 17 and 19 displayed anti-proliferative effects against HepG2 cells with IC50 values of 25.59 and 2.30 μM, respectively. Furthermore, the flow cytometry analysis and Western blotting assays revealed that compound 19 significantly induced apoptosis of HepG2 cells by downregulating the ratio of Bcl-2/Bax and upregulating the expression of cleaved caspase-3 and cleaved caspase-9. Therefore, the potential pharmaceutical applications of P. cablin would be applied according to our study findings.
The Multi-Ethnic Study of Atherosclerosis-Calcium Score Improves Statin Treatment Allocation in Asymptomatic Adults
Authors: Shlomai Gadi , Shemesh Joseph , Segev Shlomo , Koren-Morag Nira , Grossman Ehud 
Published: July 2022

BackgroundThe current categorization of cardiovascular (CV) risk broadens the indications for statin therapy. Coronary artery calcium (CAC) identifies those who are most likely to benefit from primary prevention with statin therapy. The multi-ethnic study of atherosclerosis-calcium (MESA-C) includes CAC for CV risk stratification.ObjectiveWe aimed to establish whether the MESA-C score improves allocation to statin treatment in a cohort of asymptomatic adults. We also analyzed patient survival according to their risk score calculation.DesignA retrospective analysis of asymptomatic adults.ParticipantsA total of 632 consecutive subjects free of coronary artery disease (CAD) and/or stroke, mean age 56 ± 7 years, 84% male, underwent clinical evaluations and CAC measurements.Main MeasuresPCE and MESA-C risk scores were calculated for each subject. According to the 10-year risk for CV events, subjects were classified into moderate and high CV risk (≥7.5%) for whom a statin is clearly indicated, or borderline and low CV risk (&lt;7.5%).Key ResultsDuring mean follow-up of 6.5 ± 3.3 years, 52 subjects experienced their first CV event. Those with a MESA-C risk score &lt; 7.5% had favorable outcomes even when the PCE indicated a risk of ≥ 7.5%. The MESA-C score improved the discrimination of CV risk with the ROC curves C-statistics increasing from 0.653 for the PCE to 0.770 for the MESA-C. Of those, 84% (99/118) with borderline CV risk (5–7.5%) according to the PCE score, were reallocated by the MESA-C score into a higher (≥7.5%) or lower (&lt;5%) CV risk category. Furthermore, subjects with low MESA-C scores had the highest survival rate regardless of the PCE risk, while those with high MESA-C risks had the lowest survival rate regardless of the PCE risk.ConclusionIn asymptomatic subjects, the MESA-C score improves allocation to statin treatment and CV risk discrimination, while both scores are essential for more precise survival estimations.
Impact of Extracorporeal Membrane Oxygenation on Right Ventricular Function After Heart Transplantation
Authors: Zhao Cheng , Hao Xing , Xue Chao , Zhao Yichen , Han Jie , Jia Yixin , Hou Xiaotong , Wang Jiangang 
Published: July 2022

AimsAcute right ventricular failure remains a common challenging clinical syndrome in heart transplant (HTx) recipients. While extracorporeal membrane oxygenation (ECMO) is a proven strategy for the treatment of this condition, the outcomes after weaning and during follow up remain understudied. We aimed to evaluate the right-sided heart function in ECMO survivors following HTx.MethodsBetween September 2005 and December 2019, 205 patients with end-stage heart failure who underwent standard orthotopic HTx were enrolled. In total, 68 (33.2%) patients were included in the ECMO group and 137 (66.8%) patients were included in the non-ECMO group.ResultsOf the 68 patients in the ECMO group, 42 (61.8%) were successfully weaned from ECMO. After a median follow-up period of 53 months, there were 25 (59.5%) and 27 (23.7%) deaths in the ECMO and non-ECMO groups (P = 0.023), respectively. Systolic pulmonary artery pressure (SPAP) before discharge (P = 0.003) was the unique predictor of all-cause mortality during follow up. Meanwhile, patients in the ECMO group with more than moderate SPAP increase before discharge had higher mortality than patients in the non-ECMO group without such increase (P = 0.005).ConclusionsRecipient right-sided heart characteristics were strong predictors of ECMO need after HTx. ECMO patients had high mortality in the perioperative and follow-up periods, and the changes in right ventricular function in ECMO patients may be associated with pulmonary vessel injury before and after HTx.
Phosphorous remediation using alginate/glomalin biobeads: Examining structural cohesivity, nutrient retention, and reapplication viability
Authors: Percivall Kelly , Amgain Naba R. , Inglett Kanika , Strauss Sarah L. , Bhadha Jehangir H. 
Published: July 2022

Excess nutrient loading from agriculture and urban runoff into limnetic and marine ecosystems is associated with harmful algal blooms that result in eutrophication. Sequestration of nutrients such as phosphorus (P) and nitrogen (N) from agricultural outflows and recycling them as soil amendments would be an environmentally and economically sustainable strategy to alleviate this problem. This study explored the use of biobeads constructed with phytoplankton, Chlorella vulgaris, alginate and glomalin as a possible medium for a cyclic culture-harvest-reapply (CHR) system to address the problem of eutrophication. These “biobeads” were constructed from different concentrations of sodium alginate, C. vulgaris, and glomalin. Bead vitality was evaluated by introducing C. vulgaris to both eutrophic (phosphate ∼1.5 ppm) and hypereutrophic (phosphate ∼4.0 ppm) solutions and measuring phosphate removal. After 9 days in the eutrophic solution, biologically active groups reduced orthophosphate concentrations by an average of 1.35 ppm (80%). In the hypereutrophic solution, an average of 1.52 ppm total phosphate removal (38%) was observed over 5 weeks. The addition of glomalin in high concentrations increased the structural cohesivity of the hydrogel matrix, while low concentrations had an inverse effect. Reapplication of these biobeads to topsoil did not reduce plant growth or plant health parameters. These data suggest that glomalin, in appropriate proportions, is a suitable secondary scaffolding for a sodium alginate hydrogel immobilization medium. The alginate beads of immobilized C. vulgaris could be a promising treatment technique for phosphorus-containing urban wastewater. Further research is warranted to assess long-term impacts on nutrient dispersal and soil quality upon reapplication.
The importance of complete and high-quality genome sequences in Aspergillus niger research
Authors: Ellena Valeria , Steiger Matthias G. 
Published: July 2022

The possibility to sequence the entire genome of an organism revolutionized the fields of biology and biotechnology. The first genome sequence of the important filamentous fungus Aspergillus niger was obtained in 2007, 11 years after the release of the first eukaryotic genome sequence. From that moment, genomics of A. niger has seen major progresses, facilitated by the advances in the sequencing technologies and in the methodologies for gene function prediction. However, there are still challenges to face when trying to obtain complete genomes, equipped with all the repetitive sequences that they contain and without omitting the mitochondrial sequences.The aim of this perspective article is to discuss the current status of A. niger genomics and draw attention to the open challenges that the fungal community should address to move research of this important fungus forward.
Examining the expansion of Spartina alterniflora in coastal wetlands using an MCE-CA-Markov model
Authors: Yan Dandan , Li Jingtai , Xie Siying , Liu Yao , Sheng Yufeng , Luan Zhaoqing 
Published: July 2022

The spread ofSpartina alterniflora(smooth cordgrass) has put biodiversity and ecosystem function at risk since it was introduced to China just a few decades ago. A better understanding of how the range ofS. alterniflorawill expand in the future will help manage the invasion of this species in coastal wetlands. However, it is difficult to model the future extent ofSpartinasaltmarshes in China. To address this issue, we combined multi criteria evaluation with traditional CA Markov model to provide robust forecasting of the spatial expansion ofS. alterniflorafor the next ten years, at Dafeng Milu National Nature Reserve, Jiangsu, China. Our results showed that, compared with the interpretation results of high-resolution remote sensing images in 2020, the kappa coefficient of verification accuracy was 82.63%, indicating that the MCE-CA-Markov model has good prediction results. Therefore, the model can forecast the expansion process ofS. alternifloraover the next ten years. The model predicts that the area ofS. alternifloracontinued to decrease from 910.25 ha in 2020 to 881.21 ha in 2030. The spatial distribution ofS. alterniflorahas been decreasing on the landward side while it has been expanding towards the sea on the seaward side. This study provides some suggestions for effective management and control of invasive species, which could be important for wetland biodiversity conservation and resource management.
Comparison of the Efficacy and Safety of Single-Session OK-432 and Multiple-Session 99% Ethanol Sclerotherapy for Symptomatic Simple Hepatic Cysts
Authors: Mo Zhiqiang , Yang Fangfang , Lv Ling , He Jian , Gou Qin , Chen Xiaoming , Zhuang Wenhang , Mai Qicong 
Published: July 2022

PurposeThis retrospective study aimed to compare the efficacy and safety of single-session OK-432 and multiple-session 99% ethanol sclerotherapy for symptomatic simple hepatic cysts.MethodsWe reviewed patients who received aspiration sclerotherapy with OK-432 (group A) or 99% ethanol (group B) for symptomatic simple hepatic cysts at Guangdong Provincial People's Hospital from January 2013 to November 2019.ResultsWe included 42 patients in group A and 39 patients in group B. No significant difference was found in the mean volume of hepatic cysts between the two groups. The overall success rates were 92.9% (39 of 42 patients) in group A and 79.5% (31 of 39 patients) in group B (P = 0.08). The treatment success for cyst volumes &lt;200 ml, 200–500 ml, and &gt;500 ml was 100, 93.3, and 88.2% in group A, and 100, 84.6, and 57.1% in group B, respectively. The symptomatic relief rate in group A was higher than that in group B for cysts ≥500 ml (P = 0.049) and cysts &lt;500 ml. For treatment-related complications, the incidence of pain at the injection site in group A was lower than that in group B.ConclusionSingle-session OK-432 sclerotherapy was safer and more effective than multiple-session 99% ethanol sclerotherapy for treating large cysts, although both treatments had similar effects on small cysts.
Extracorporeal membrane oxygenation support for lung transplantation: Initial experience in a single center in China and a literature review
Authors: Zhao Yanfeng , Su Yiliang , Duan Ruowang , Song Jiong , Liu Xiaogang , Shen Lei , Ding Junrong , Zhang Pei , Bao Minwei , Chen Chang , Zhu Yuming , Jiang Gening , Li Yuping 
Published: July 2022

BackgroundExtracorporeal membrane oxygenation (ECMO) is a versatile tool associated with favorable outcomes in the field of lung transplantation (LTx). Here, the clinical outcomes and complications of patients who underwent LTx with ECMO support, mainly prophylactically both intraoperatively and post-operatively, in a single center in China are reviewed.MethodsThe study cohort included all consecutive patients who underwent LTx between January 2020 and January 2022. Demographics and LTx data were retrospectively reviewed. Perioperative results, including complications and survival outcomes, were assessed.ResultsOf 86 patients included in the study, 32 received ECMO support, including 21 who received prophylactic intraoperative use of ECMO with or without prolonged post-operative use (pro-ECMO group), while the remaining 54 (62.8%) received no external support (non-ECMO group). There were no significant differences in the incidence of grade 3 primary graft dysfunction (PGD), short-term survival, or perioperative outcomes and complications between the non-ECMO and pro-ECMO groups. However, the estimated 1- and 2-year survival were superior in the pro-ECMO group, although this difference was not statistically significant (64.1% vs. 82.4%, log-rank P = 0.152; 46.5% vs. 72.1%, log-rank P = 0.182, respectively). After regrouping based on the reason for ECMO support, 30-day survival was satisfactory, while 90-day survival was poor in patients who received ECMO as a bridge to transplantation. However, prophylactic intraoperative use of ECMO and post-operative ECMO prolongation demonstrated promising survival and acceptable complication rates. In particular, patients who initially received venovenous (VV) ECMO intraoperatively with the same configuration post-operatively achieved excellent outcomes. The use of ECMO to salvage a graft affected by severe PGD also achieved acceptable survival in the rescue group.ConclusionsProphylactic intraoperative ECMO support and post-operative ECMO prolongation demonstrated promising survival outcomes and acceptable complications in LTx patients. Particularly, VV ECMO provided safe and effective support intraoperatively and prophylactic prolongation reduced the incidence of PGD in selected patients. However, since this study was conducted in a relatively low-volume transplant center, further studies are needed to validate the results.
Cerebral small vessel disease mediates the association between homocysteine and cognitive function
Authors: Teng Zhenjie , Feng Jing , Liu Ronghui , Ji Yifan , Xu Jing , Jiang Xin , Chen Huifang , Dong Yanhong , Meng Nan , Xiao Yining , Xie Xiaohua , Lv Peiyuan 
Published: July 2022

ObjectiveTo investigate the relations of serum total homocysteine (tHcy) with cerebral small vessel disease (CSVD) and cognitive function and evaluate whether CSVD mediates the effect of serum tHcy on cognitive function.MethodsA total of 1,033 consecutive eligible participants who received serum tHcy, brain magnetic resonance imaging (MRI), and neuropsychological assessment were included in this retrospective study. White matter hyperintensity, lacune, cerebral microbleed, and enlarged perivascular space were evaluated based on brain MRI. We used multivariate binary logistic regression analysis, multivariate ordinal logistic regression analysis, and mediation analyses to assess the relations of serum tHcy with CSVD and cognitive function.ResultsSerum tHcy levels were higher in patients with cognitive impairment than those with no cognitive impairment. Logistic regression analyses showed elevated serum tHcy was associated with cognitive impairment [odds ratio (OR): 10.475; 95% confidence interval (CI): 4.522 to 24.264; p &lt; 0.001] and a higher CSVD burden score (OR: 17.151; 95% CI: 8.785 to 33.921; p &lt; 0.001) after adjusting potential confounders. Compared with the lowest tHcy quartile, the multivariable-adjusted OR of the highest quartile was 4.851 (95% CI: 3.152 to 7.466; p for the trend &lt; 0.001) for cognitive impairment, 3.862 (95% CI: 2.467 to 6.047; p for the trend &lt; 0.001) for a severe CSVD burden score. Mediation analyses showed significant moderating effects (9.3–23.6%) by different imaging markers of CSVD on the association between higher serum tHcy levels and cognitive impairment.ConclusionElevated serum tHcy is associated with cognitive impairment and the development of CSVD. A proportion of the association between elevated serum tHcy and cognitive impairment may be attributed to the presence of different imaging markers of CSVD, especially the severe CSVD burden score.
A Systematic Review on Neurological Aspects of COVID-19: Exploring the Relationship Between COVID-19-Related Olfactory Dysfunction and Neuroinvasion
Authors: Purja Sujata , Oh SuA , Kim EunYoung 
Published: July 2022

ObjectivesTo identify neurological aspects of Coronavirus disease 2019 (COVID-19) and to investigate COVID-19 infected patients with and without olfactory dysfunction in relation to polymerase chain reaction (PCR) assay results for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in the cerebrospinal fluid (CSF).MethodsPubMed and EMBASE databases were searched until March 26, 2021, for observational studies with COVID-19 patients that had performed CSF PCR assay due to the neurologic symptom and reported anosmia status.ResultsInitially, 2,387 studies were identified;167 studies performed SARS-CoV-2 CSF PCR assay, of which our review comprised 45 observational studies that conducted CSF PCR assay for SARS-CoV-2 in 101 patients and reported anosmia status in 55 of 101 patients. Central and peripheral neurological manifestations observed in COVID-19 patients were diverse. The most common neurological diagnoses were Guillain-Barré syndrome (GBS) and its variants (24%), followed by encephalopathy (21%). The SARS-CoV-2 PCR assay was positive in only four CSF samples, of which two patients had olfactory dysfunction while the others did not.ConclusionsThe neurological spectrum of COVID-19 is diverse, and direct neuroinvasion of SARS-CoV-2 is rare. The neuroprotection against SARS-CoV-2 in COVID-19 patients with anosmia is controversial, as an equal number of patients with and without olfactory dysfunction had positive CSF PCR results for SARS-CoV-2 in our study, and further studies are required to provide more insight into this topic.