bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benefits of task‐specific movement program on en bloc turning in Parkinson's disease: A randomized controlled trial
Authors: Khobkhun Fuengfa , Hollands Mark , Tretriluxana Jarugool , Srivanitchapoom Prachaya , Richards Jim , Ajjimaporn Amornpan 
Published: June 2022

AbstractIntroductionEn bloc turning highlights a lack of rotational intersegmental coordination, which commonly impacts turning ability in people with Parkinson's disease (PD). Whilst this turning deficit responds fairly well to medical treatment, it may be further mitigated by performing specific exercise training. Thus, the present study aimed to examine the effects of a 4‐week exercise program, which focused on task‐specific movements (TSM program) on turning ability and clinical outcomes in people with PD.MethodsTwenty‐two adults (67 ± 6 years) with early‐to‐mid‐stage idiopathic PD were randomly assigned to an experimental group (EG; n = 11) or a control group (CG; n = 11). The exercise group (EG) group received a 60‐min per session TSM program for 4 weeks (a total of 15 sessions), while the CG group performed their routine rehabilitation program (a total of 12 sessions). Inertial measurement units were used to measure turning kinematics including; onset latency of body segments and stepping characteristics. Clinical outcomes included the Unified Parkinson's Disease Rating Scale (UPDRS), functional reach test (FRT), and fall efficacy scale international (FES‐I). Assessments were conducted at baseline and after 4 weeks.ResultsIn the EG, turning kinematics, UPDRS scores, FRT, and FES‐I scale, were improved at the end of the 4‐week program compared with the CG (all p < 0.05).Impact StatementA 4‐week TSM program could be a promising alternative rehabilitation program for improving “en bloc” turns and clinical outcomes in PD patients.
Dynamic downscaling and daily nowcasting from influenza surveillance data
Authors: Paul Rajib , Han Dan , DeDoncker Elise , Prieto Diana 
Published: June 2022

AbstractReal‐time trends from surveillance data are important to assess and develop preparedness for influenza outbreaks. The overwhelming testing demand and limited capacity of testing laboratories for viral positivity render daily confirmed case data inaccurate and delay its availability in preparedness. Using Bayesian dynamic downscaling models, we obtained posterior estimates for daily influenza incidences from weekly estimates of the Centers for Disease Control and Prevention and daily reported constitutional and respiratory complaints during emergency department (ED) visits obtained from the state health departments. Our model provides one‐day and seven‐day lead forecasts along with 95 prediction intervals. Our hybrid Markov Chain Monte Carlo and Kalman filter algorithms facilitate faster computation and enable us to update our estimates as new data become available. Our method is tested and validated using the State of Michigan data over the years 2009‐2013. Reported constitutional and respiratory complaints at the EDs showed strong correlations of 0.81 and 0.68 respectively, with influenza rates. In general, our forecast model can be adapted to track an outbreak with only one respiratory virus as a causative agent.
Stability of symptoms of psychological distress: A 13‐year study using Australian national data
Authors: Joshanloo Mohsen 
Published: June 2022

AbstractThis study examined the stability of 10 symptoms of psychological distress measured by the Kessler Psychological Distress Scale (K10) in an Australian adult sample. Data were collected at seven time points, 2 years apart, between 2007 and 2019. The average stability of the 10 symptoms was 49%. However, there were differences between items. The items can be categorised based on two characteristics: Degree of extremity and arousal. More extreme symptoms (i.e., those beginning with ‘so’, such as ‘so sad that...’) tended to change more over time, whereas milder symptoms (e.g., “nervous”) tended to be more stable. Symptoms with low levels of arousal (e.g., ‘hopeless’) tended to reflect more situation‐specific influences, whereas symptoms with high levels of arousal (e.g., ‘restless or fidgety’) tended to reflect more nonsystematic influences.
Label‐Free Quantification of Molecular Interaction in Live Red Blood Cells by Tracking Nanometer Scale Membrane Fluctuations
Authors: Yao Bo , Yang Yunze , Yu Nanxi , Tao Nongjian , Wang Di , Wang Shaopeng , Zhang Fenni 
Published: June 2022

AbstractMolecular interactions in live cells play an important role in both cellular functions and drug discovery. Current methods for measuring binding kinetics involve extracting the membrane protein and labeling, while the in situ quantification of molecular interaction with surface plasmon resonance (SPR) imaging mainly worked with fixed cells due to the micro‐motion related noises of live cells. Here, an optical imaging method is presented to measure the molecular interaction with live red blood cells by tracking the nanometer membrane fluctuations. The membrane fluctuation dynamics are measured by tracking the membrane displacement during glycoprotein interaction. The data are analyzed with a thermodynamic model to determine the elastic properties of the cell observing reduced membrane fluctuations under fixatives, indicating cell fixations affect membrane mechanical properties. The binding kinetics of glycoprotein to several lectins are obtained by tracking the membrane fluctuation amplitude changes on single live cells. The binding kinetics and strength of different lectins are quite different, indicating the glycoproteins expression heterogeneity in single cells. It is anticipated that the method will contribute to the understanding of mechanisms of cell interaction and communication, and have potential applications in the mechanical assessment of cancer or other diseases at the single‐cell level, and screening of membrane protein targeting drugs.
Development of Biodegradable Osteopromotive Citrate‐Based Bone Putty
Authors: Tan Xinyu , Gerhard Ethan , Wang Yuqi , Tran Richard T. , Xu Hui , Yan Su , Rizk Elias B. , Armstrong April D. , Zhou Yuxiao , Du Jing , Bai Xiaochun , Yang Jian 
Published: June 2022

AbstractThe burden of bone fractures demands development of effective biomaterial solutions, while additional acute events such as noncompressible bleeding further motivate the search for multi‐functional implants to avoid complications including osseous hemorrhage, infection, and nonunion. Bone wax has been widely used in orthopedic bleeding control due to its simplicity of use and conformation to irregular defects; however, its nondegradability results in impaired bone healing, risk of infection, and significant inflammatory responses. Herein, a class of intrinsically fluorescent, osteopromotive citrate‐based polymer/hydroxyapatite (HA) composites (BPLP‐Ser/HA) as a highly malleable press‐fit putty is designed. BPLP‐Ser/HA putty displays mechanics replicating early nonmineralized bone (initial moduli from ≈2–500 kPa), hydration induced mechanical strengthening in physiological conditions, tunable degradation rates (over 2 months), low swelling ratios (<10%), clotting and hemostatic sealing potential (resistant to blood pressure for >24 h) and significant adhesion to bone (≈350–550 kPa). Simultaneously, citrate's bioactive properties result in antimicrobial (≈100% and 55% inhibition of S. aureus and E. coli) and osteopromotive effects. Finally, BPLP‐Ser/HA putty demonstrates in vivo regeneration in a critical‐sized rat calvaria model equivalent to gold standard autograft. BPLP‐Ser/HA putty represents a simple, off‐the‐shelf solution to the combined challenges of acute wound management and subsequent bone regeneration.
The effect of hoisting on variants of Hierarchical Delta Debugging
Authors: Vince Dániel , Hodován Renáta , Bársony Daniella , Kiss Ákos 
Published: June 2022

AbstractMinimizing failing test cases is an important preprocessing step on the path of debugging. If much of a test case that triggered a bug does not contribute to the actual failure, then the time required to fix the bug can increase considerably. However, test case reduction itself can be a time‐consuming task, especially if done manually. Therefore, automated minimization techniques have been proposed, the minimizing Delta Debugging and the Hierarchical Delta Debugging (HDD) algorithms being the most well known. In this paper, we investigated the input format of HDD, searching for structures that the algorithm cannot reduce. Motivated by the findings, we have created an algorithmic framework that enabled the use of transformations other than pruning. Furthermore, with the Transformation‐based Minimization framework, we propose to extend HDD and its coarse and recursive variants with a reduction method that does not prune subtrees but replaces them with compatible subtrees further down the hierarchy, called hoisting. We have evaluated various combinations of pruning and hoisting on multiple test suites and found that hoisting can help to further reduce the size of test cases by 27% on average and by 80% as best case compared with the baseline algorithm.
Efficacy of the Oral Administration of Maltodextrin Fructose Before Major Abdominal Surgery: A Prospective, Multicenter Clinical Study
Authors: Qin Huanlong , Ji Jiafu , Miao Yi , Liu Tong , Zhao Dongbing , Jia Zhenyi , Jiang Jun , Liu Jiang , Li Qiang , Ji Xi , Fu Weihua , Lou Donghua , Xia Wenyu , Li Ning 
Published: June 2022

AbstractBackgroundTo study the efficacy of the oral administration of maltodextrin and fructose before major abdominal surgery (MAS).MethodsThis prospective, multicenter, parallel‐controlled, double‐blind study included patients aged 45–70 years who underwent elective gastrectomy, colorectal resection, or duodenopancreatectomy. The intervention group (IG) was given 800 mL and 400 mL of a maltodextrin and fructose beverage at 10 h and 2 h before MAS, respectively, and the control group (CG) received water under the same experimental conditions. The primary endpoint was insulin resistance index (IRI), and the secondary endpoints were fasting blood glucose, fasting insulin, insulin secretion index, insulin sensitivity index, intraoperative blood glucose, subjective comfort score, and clinical outcome indicators.ResultsA total of 240 cases were screened, of which 231 cases were randomly divided into two groups: 114 in the IG and 117 in the CG. No time‐treatment effect was detected for any endpoint. The IRI and fasting insulin were significantly lower in the IG than CG after MAS (p = 0.02 & P = 0.03). The scores for anxiety, appetite, and nausea were significantly lower in the IG than CG at 1 h before MAS. Compared with baseline, the scores for appetite and nausea decreased in the IG but increased in the CG.ConclusionThe oral administration of maltodextrin and fructose before MAS can improve preoperative subjective well‐being and reduce postoperative insulin resistance without increasing the risk of gastrointestinal discomfort.
Associations of 24 h urinary excretions of α- and γ-carboxyethyl hydroxychroman with plasma α- and γ-tocopherol and dietary vitamin E intake in older adults: the Lifelines-MINUTHE Study
Authors: Zhu Yinjie , Frank Jan , Riphagen Ineke J. , Minović Isidor , Vos Michel J. , Eggersdorfer Manfred L. , Navis Gerjan J. , Bakker Stephan J. L. 
Published: June 2022

Abstract
Background
Urinary metabolites of vitamin E, i.e., α- and γ-carboxyethyl hydroxychroman (α- and γ-CEHC), have gained increasing attention and have been proposed as novel biomarkers of vitamin E intake and status. However, there are insufficient data on the relationship of plasma α-tocopherol and γ-tocopherol and dietary vitamin E intake with 24 h urinary excretions of α- and γ-CEHC.

Objectives
We aimed to (1) investigate the associations of urinary α- and γ-CEHC/creatinine ratios and 24 h urinary excretions of α- and γ-CEHC with plasma α- and γ-tocopherol, respectively; (2) investigate the associations of urinary α- and γ-CEHC/creatinine ratios and 24 h urinary excretions of α- and γ-CEHC with dietary vitamin E intake, and we hypothesize that 24 h urinary excretions of α- and γ-CEHC will better correlate with vitamin E intake than urinary α- and γ-CEHC/creatinine ratios.

Design
24 h Urine and plasma samples were collected from 1519 participants (60–75 years, male: 50%) included in the Lifelines-MINUTHE Study for the assessments of urinary α- and γ-CEHC/creatinine ratios and 24 h urinary excretions of α- and γ-CEHC, and plasma α- and γ-tocopherol. Among those participants, dietary vitamin E intake data from 387 participants were available from an externally validated Flower-Food Frequency Questionnaire (FFQ). The associations of plasma α- and γ-tocopherol, dietary vitamin E intake, with urinary α- and γ-CEHC were assessed using multivariate linear regressions.

Results
24 h Urinary excretion of α-CEHC (median (IQR): 0.9 (0.3–2.4) µmol) was less than that of γ-CEHC (median (IQR): 1.5 (0.5–3.5) µmol). After adjustment for covariates, we found that 24 h urinary α-CEHC excretion and urinary α-CEHC/creatinine ratio were both positively associated with plasma α-tocopherol (std.beta: 0.06, p = 0.02; std.beta: 0.06, p = 0.01, respectively). Furthermore, the sum of 24 h urinary α- and γ-CEHC excretions was positively associated with dietary vitamin E intake (std.beta: 0.08; p = 0.03), whereas there was no relation between urinary α- and γ-CEHC/creatinine ratios and vitamin E intake. No association was observed neither between plasma α- and γ-tocopherol and dietary vitamin E intake, nor between urinary γ-CEHC and plasma γ-tocopherol.

Conclusion
Our study confirmed our hypothesis that 24 h urinary α- and γ-CEHC excretions would be a better marker for dietary vitamin E intake than urinary α- and γ-CEHC/creatinine ratios. Considering that both 24 h urinary α- and γ-CEHC excretions and α- and γ-CEHC/creatinine ratios were also associated with plasma α-tocopherol status, we suggest that 24 h urinary α- and γ-CEHC excretions could be used to assess overall vitamin E status.
Serum anti-NMDA-receptor antibodies and cognitive function after ischemic stroke (PROSCIS-B)
Authors: Sperber Pia S. , Gebert Pimrapat , Broersen Leonie H. A. , Huo Shufan , Piper Sophie K. , Teegen Bianca , Heuschmann Peter U. , Prüss Harald , Endres Matthias , Liman Thomas G. , Siegerink Bob 
Published: June 2022

Abstract
Objective
We aimed to investigate whether serum anti-N-methyl-D-aspartate-receptor GluN1 (previously NR1) antibody (NMDAR1-abs) seropositivity impacts cognitive function (CF) in the long term following ischemic stroke.

Methods
Data were used from the PROSpective Cohort with Incident Stroke-Berlin. NMDAR1-abs (IgM/IgA/IgG) were measured with cell-based assays from serum obtained within 7 days after the first-ever stroke. Seropositivity was defined as titers ≥ 1:10, low titers as ≤ 1:100 and high titers as > 1:100. We assessed CF at 1, 2 and 3 years after stroke with the Telephone Interview for Cognitive Status-modified (TICS-m) and used crude and propensity score adjusted inverse probability weighted generalized linear models to estimate the impact of NMDAR1-abs serostatus on TICS-m.

Results
Data on NMDAR1-abs (median day of sampling = 4[IQR = 2–5]) were available in 583/621 PROSCIS-B patients (39% female; median NIHSS = 2[IQR = 1–4]; median MMSE = 28[IQR:26–30]), of whom 76(13%) were seropositive (IgM: n = 48/IgA: n = 43/IgG: n = 2). Any NMDAR1-abs seropositivity had no impact on TICS-m compared to seronegative patients (βcrude = 0.69[95%CI = – 0.84 to 2.23]; βadjusted = 0.65[95%CI = – 1.00 to 2.30]). Patients with low titers scored better on TICS-m compared to seronegative patients (βcrude = 2.33[95%CI = 0.76 to 3.91]; βadjusted = 2.47[95%CI = 0.75 to 4.19]); in contrast, patients with high titers scored lower on TICS-m (βcrude =  –2.82[95%CI = – 4.90 to – 0.74], βadjusted = – 2.96[95%CI = – 5.13 to – 0.80]), compared to seronegative patients.

Conclusion
In our study, NMDAR1-abs seropositivity did not affect CF over 3 years after a first mild to moderate ischemic stroke. CF differed according to NMDAR1-abs serum titer, with patients with high NMDAR1-abs titers having a less favorable cognitive outcome compared to seronegative patients.
When time stands upright: STEARC effects along the vertical axis
Authors: Dalmaso Mario , Schnapper Youval , Vicovaro Michele 
Published: June 2022

AbstractAccording to the spatial–temporal association of response codes (STEARC) effect, time can be spatially represented from left to right. However, exploration of a possible STEARC effect along the vertical axis has yielded mixed results. Here, in six experiments based on a novel paradigm, we systematically explored whether a STEARC effect could emerge when participants were asked to classify the actual temporal duration of a visual stimulus. Speeded manual responses were provided using a vertically oriented response box. Interestingly, although a top-to-bottom time representation emerged when only two temporal durations were employed, an inverted bottom-to-top time representation emerged when a denser set of temporal durations, arranged along a continuum, was used. Moreover, no STEARC effects emerged when participants classified the shapes of visual stimuli rather than their temporal duration. Finally, three additional experiments explored the STEARC effect along the horizontal axis, confirming that the paradigm we devised successfully replicated the standard left-to-right representation of time. These results provide supporting evidence for the notion that temporal durations can be mapped along the vertical axis, and that such mapping appears to be relatively flexible.
Analysis of moving cluster with scene constraints for group behavior pattern mining
Authors: Yang Yuanfeng , Li Lin , Zhang Liang , Liu Gang , Liu Zhaobin 
Published: June 2022

AbstractGroup behavior pattern mining in traffic scenarios is a challenging problem due to group variability and behavioral regionality. Most methods are either based on trajectory data stored in static databases regardless of the variability of group members or do not consider the influence of scene structures on behaviors. However, in traffic scenarios, information about group members may change over time, and objects' motions show regional characteristics owing to scene structures. To address these issues, we present a general framework of a moving cluster with scene constraints (MCSC) discovery consisting of semantic region segmentation, mapping, and an MCSC decision. In the first phase, a hidden Markov chain is adopted to model the evolution of behaviors along a video clip sequence, and a Markov topic model is proposed for semantic region analysis. During the mapping procedure, to generate snapshot clusters, moving objects are mapped into the corresponding sets of moving objects according to the semantic regions where they are located at each timestamp. In the MCSC decision phase, a candidate MCSC recognition algorithm and screening algorithm are designed to incrementally identify and output MCSCs. The effectiveness of the proposed approach is verified by experiments carried out using public road traffic data.
The Fractional CIO in SMEs: conceptualization and research agenda
Authors: Kratzer Simon , Drechsler Andreas , Westner Markus , Strahringer Susanne 
Published: June 2022

AbstractWe conceptualize the new phenomenon of the Fractional Chief Information Officer (CIO) as a part-time executive who usually works for more than one primarily small- to medium-sized enterprise (SME) and develop promising avenues for future research on Fractional CIOs. We conduct an empirical study by drawing on semi-structured interviews with 40 individuals from 10 different countries who occupy a Fractional CIO role. We derive a definition for the Fractional CIO, distinguish it from other forms of employment, and compare it with existing research on CIO roles. Further, we find four salient engagement types of Fractional CIOs offering value for SMEs in various situations: Strategic IT management, Restructuring, Rapid scaling, and Hands-on support. The results reveal similarities with existing CIO roles as well as novel insights concerning the different engagement types. Lastly, we propose a research agenda for the Fractional CIO field, based on four research themes derived from existing CIO research and insights from the interviews.
Charophyte communities in Barremian Iberian wetlands
Authors: Pérez-Cano Jordi , Bover-Arnal Telm , Martín-Closas Carles 
Published: June 2022

AbstractA combined micropalaeontological, taphonomical and sedimentological study was carried out in the non-marine Barremian of the Maestrat Basin (E Iberian Chain) to elucidate the palaeoecology of Barremian charophytes. Understanding the palaeoecology of fossil charophytes is of prime importance for the accurate application of charophyte biozonations, since most species used as biostratigraphic markers and/or biozone index species are restricted to facies formed in a particular environment. Five charophyte biocoenoses were distinguished. (1) Charophyte association from freshwater alkaline lakes receiving low clastic input, mainly composed of Atopochara trivolvis var. triquetra, Clavator harrisii, Ascidiella stellata, and A. triquetra. The thalli known as Munieria grambastii, corresponding to Clavator utricles, were extremely abundant in the shallowest facies of the lake margins, and Hemiclavator-rich populations were also locally dominant. (2) An association characteristic of freshwater alkaline lakes with high clastic input was mainly composed of Echinochara lazarii, Globator maillardii var. trochiliscoides, A. trivolvis var. triquetra, C. harrisii, Hemiclavator neimongolensis var. neimongolensis, and locally also Clavator calcitrapus. (3) Monospecific populations of Porochara maestratica thrived in brackish settings with little clastic influence, whereas (4) monospecific E. lazarii populations thrived in clastic-influenced brackish settings. (5) A charophyte association grew in lakes that developed in mudflat to floodplain environments and was mainly constituted by E. lazarii, A. trivolvis var. triquetra, and C. harrisii var. harrisii and var. reyi. Accordingly, the palaeoenvironmental conditions inferred indicate that most of the charophyte species were controlled by (i) bathymetry, (ii) clastic content in the sedimentary environment and (iii) salinity. The stratigraphic succession studied shows an upwards increase in clastic content from the base to the top, which is associated with the more humid period recorded along the margins of the Tethys and the Boreal realm during the early Barremian–early late Barremian. In consequence, those species restricted to clastic-poor settings are constrained to the lower part of the section, whereas those taxa that were able to thrive in clastic-rich settings persisted throughout the entire section. This observation establishes a link between the changes observed in the charophyte floras recognized and the environmental changes that occurred during the Barremian in western Europe.
Philosophy of science in practice in ecological model building
Authors: Poliseli Luana , Coutinho Jeferson G. E. , Viana Blandina , Russo Federica , El-Hani Charbel N. 
Published: June 2022

AbstractThis article addresses the contributions of the literature on the new mechanistic philosophy of science for the scientific practice of model building in ecology.
This is reflected in a one-to-one interdisciplinary collaboration between an ecologist and a philosopher of science during science-in-the-making. We argue that the identification, reconstruction and understanding of mechanisms is context-sensitive, and for this case study mechanistic modeling did not present a normative role but a heuristic one. We expect our study to provides useful epistemic tools for the improvement of empirically-riven work in the debates about mechanistic explanation of ecological phenomena.