bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nachhaltige Steigerung der Aktivität durch Rehabilitation
Authors: Reuß-Borst Monika , Boschmann Johannes , Borst Fabian 
Published: March 2022

ZusammenfassungPatienten mit muskuloskeletalen Erkrankungen sind deutlich weniger körperlich aktiv als Gesunde. Sie können von einer Steigerung der körperlichen Aktivität und einer nachhaltigen Veränderung des Lebensstils in vielerlei Hinsicht profitieren, wozu eine stationäre Rehabilitation in erheblichem Maße beitragen kann. In dieser prospektiven Beobachtungsstudie (Prä-Post-Design) wurden körperliche Aktivität (mit dem Freiburger Fragebogen zur körperlichen Aktivität) und Depressivität (mit dem Beck-Depressions-Inventar [BDI]) bei 202 Rehabilitanden (124 weiblich, 77 männlich) mit muskuloskeletalen Erkrankungen (ICD-Diagnosen M) zu verschiedenen Katamnesezeitpunkten (zu Beginn der Reha, nach 3, 6, 9 und 12 Monaten) erhoben. Die Aktivitätssteigerung wurde in Abhängigkeit vom Ausgangslevel und der Depressivität analysiert. Drei Monate nach Rehabilitation lag das Aktivitätsniveau 47,8 % über dem Ausgangsniveau, was einer Steigerung der Medianaktivität von 5 auf 7,2 h pro Woche entspricht; 78,6 % der Teilnehmer zeigten nach 3 Monaten eine positive Differenz zum Ausgangsniveau. Der BDI-Score nahm im Mittel bei Durchführung der Rehabilitationsmaßnahme ab; eine Korrelation zwischen Abnahme des Scores und Zunahme der körperlichen Aktivität konnte nicht gezeigt werden. Durch eine 1‑malige Intervention (3-wöchige Rehabilitation) gelang eine Steigerung der körperlichen Aktivität über 12 Monate, wobei die Höhe der Aktivitätssteigerung nicht mit dem Ausgangslevel korreliert war, sodass auch bislang inaktive Patienten von der Reha profitierten.
Evaluation of vitamin D receptor gene polymorphisms (ApaI and TaqI) as risk factors of vitiligo and predictors of response to narrowband UVB phototherapy
Authors: Youssef Youssef Elbayoumy , Eldegla Heba Elsayed Abdelmoneim , Elmekkawy Rana Samir Mahmoud , Gaballah Mohammad Ali 
Published: March 2022

AbstractVitiligo is acquired depigmentation due to multiple factors. Vitamin D in skin, through its receptors (VDR), regulates cell growth, differentiation, immune response and exerts both stimulatory and protective effects on melanocytes. The gene sequence encoding VDR has polymorphic forms such as ApaI and TaqI that may affect vitamin D actions. Narrowband ultraviolet B (NB-UVB) phototherapy became the mainstay of vitiligo treatment because of its efficacy and little side effects. The current work aimed at evaluating the possible association between VDR gene polymorphisms (TaqI and ApaI) and susceptibility of vitiligo and if they could be predictors of response to NB-UVB phototherapy in Egyptian vitiligo patients. 100 vitiligo patients indicated for NB-UVB phototherapy and 100 healthy age and sex matched controls were included. All participants were subjected to history taking, general and dermatological examinations, and VDR ApaI and TaqI gene polymorphisms analysis by PCR–RFLP. The patients received NB-UVB 3times per week for 6 months then revaluated. There was significant increase in Aa genotype of ApaI polymorphism in patients associated with significant increase in vitiligo activity. 66% of patient showed variable degrees of response to NB-UVB. The responders significantly had AA genotype of ApaI polymorphism. TaqI polymorphism showed nonsignificant effects on vitiligo susceptibility and response to NB-UVB. A allele of ApaI was significant independent predictor of NB-UVB phototherapy responders. VDR gene polymorphism (ApaI) may share in vitiligo pathogenesis and response to NB-UVB. Knowing the genetic background of the patient helps individualization of treatment to get better results.
Symptom burden and health-related quality of life six months after hyperbaric oxygen therapy in cancer survivors with pelvic radiation injuries
Authors: Velure Grete K. , Müller Bernd , Hauken May Aa. 
Published: March 2022

Abstract
Purpose
Late radiation tissue injuries (LRTIs) after treatment for pelvic cancer may impair health related quality of life (HRQoL). Hyperbaric oxygen therapy is an adjuvant therapy for LRTIs, but limited studied. The aim of this study was to explore the development and association between symptoms of LRTI and HRQoL following hyperbaric oxygen treatment.

Methods
A pretest–posttest design was used to evaluate the changes in pelvic LRTIs and HRQoL from baseline (T1), immediately after treatment (T2) and at six-month follow-up (T3). EPIC and EORTC-QLQ-C30 were used to assess LRTIs and HRQoL. Changes were analysed with t-tests, and associations with Pearson’s correlation and multiple regression analyses.

Results
Ninety-five participants (mean age 65 years, 52.6% men) were included. Scores for urinary and bowel symptoms, overall HRQoL, all function scales and the symptoms scales sleep, diarrhoea, pain and fatigue were significantly improved six months after treatment (P-range = 0.00–0.04). Changes were present already at T2 and maintained or further improved to T3. Only a weak significant correlation between changes in symptoms and overall HRQoL was found (Pearson r-range 0.20–0.27).

Conclusion
The results indicate improvement of pelvic LRTIs and HRQoL following hyperbaric oxygen therapy, corresponding to minimal or moderate important changes. Cancer survivors with pelvic LRTIs and impaired HRQoL may benefit from undergoing hyperbaric oxygen therapy. Especially the reduced symptom-severity and improved social- and role function can influence daily living positively.

Trial registration

ClinicalTrials.gov: NCT03570229. Released 2. May 2018.
Magma hybridization and crystallization in coexisting gabbroic and granitic bodies in the mid-crust, Akechi district, central Japan
Authors: Yamasaki Toru 
Published: March 2022

AbstractPetrological and geochemical features of gabbros and fine-grained mafic rocks (mafic microgranular enclaves; MMEs) in the Inagawa Granite of the Ryoke Plutonic Complex were investigated to assess the interactions between coexisting mafic and silicic magmas, and the petrogenetic relationships between the MMEs and surrounding gabbros. The MMEs exhibit mingling textures that imply the coexistence of mafic and silicic magmas that did not undergo complete mixing, but the geochemical compositions of the MMEs require substantial hybridization and homogenization. The gabbroic rocks exhibit disequilibrium textures and mineral compositions, such as quartz–hornblende ocellar textures and patchy plagioclase crystals with bimodal anorthite contents. These textures and compositions record an abrupt decrease in crystallization temperature and mechanical mixing between crystallizing gabbroic mush and silicic (granitic) melt. Geochemical variations of the gabbroic rocks can be explained by hybridization and fractional crystallization (HFC) processes between crystallizing gabbroic mush and granitic melt. Extrapolation of the mixing trend to a basaltic composition suggests that the primitive mafic end-member was a low-K basaltic magma. Given that HFC yields magnesian andesite by the addition of a small amount of silicic melt to a primitive mafic end-member, the compositional modification of mafic magmas by magma mixing might be an essential process in the formation of andesitic magma in arc crust.
Clinical performance of resin-matrix ceramic partial coverage restorations: a systematic review
Authors: Fathy Hanan , Hamama Hamdi H. , El-Wassefy Noha , Mahmoud Salah H. 
Published: March 2022

Abstract

Objective
To evaluate clinical performance of the new CAD/CAM resin-matrix ceramics and compare it with ceramic partial coverage restorations.

Materials and methods
An electronic search of 3 databases (The National Library of Medicine (MEDLINE/PubMed), Scopus, and the Cochrane Central Register of Controlled Trials) was conducted. English clinical studies published between 2005 and September 2020 that evaluated the clinical performance of CAD/CAM resin-matrix ceramics inlays, onlays, or overlays were selected. The primary clinical question was applied according to PICOS strategy (Population, Intervention, Comparison, Outcome, Study design). The included studies were individually evaluated for risk of bias according to the modified Cochrane Collaboration tool criteria.

Results
A total of 7 studies were included according to the established inclusion and exclusion criteria. From the included studies, 6 were randomized clinical trials while one study was longitudinal observational study without control group. According to the results of the included studies, the success rate of CAD/CAM resin-based composite ranged from 85.7 to 100% whereas the success rate reported for ceramic partial coverage restorations ranged from 93.3 to 100%. Fractures and debondings are found to be the most common cause of restorations failure.

Conclusion
CAD/CAM resin-based composite can be considered a reliable material for partial coverage restorations with clinical performance similar to glass ceramic restorations. However, this result needs to be confirmed in long-term evaluations.

Clinical relevance
CAD/CAM resin-based composites provide a potential alternative to ceramic indirect restorations. However, clinicians must be aware of the lake of knowledge regarding long-term outcome.
Three-dimensional assessment of facial asymmetry in Class III subjects. Part 1: a retrospective study evaluating postsurgical outcomes
Authors: Ajmera Deepal Haresh , Hsung Richard Tai-Chiu , Singh Pradeep , Wong Natalie Sui Miu , Yeung Andy Wai Kan , Lam Walter Yu Hang , Khambay Balvinder S. , Leung Yiu Yan , Gu Min 
Published: March 2022

Abstract

Objective
The present study aimed to determine the site and severity of maxillomandibular asymmetry before and after orthognathic surgery in asymmetric patients.

Materials and methods
Presurgery and postsurgery cone beam computed tomography (CBCT) data of 21 facial asymmetry patients (7 males and 14 females, mean age: 23.0 ± 3.36 years) with soft tissue chin deviation ≥ 3 mm who had undergone bimaxillary surgery were evaluated. Seven midline and twenty bilateral hard tissue landmarks were identified for the evaluation of facial asymmetry and outcomes were assessed against age- and gender-matched control subjects.

Results
In the asymmetry group, bilateral landmarks exhibited significant deviation in the mandible and midface regions. Before surgery, asymmetry was more severe at the mandibular midline and sites close to it, in the asymmetry group. Bimaxillary surgery proved to be highly effective, with a significant correction of the menton to a clinically normal value (2.90 mm, p < 0.001). After surgery, significant residual asymmetry was observed at the mental foramen (p = 0.001) in the R-L direction. Moreover, significant asymmetry persisted at the sigmoid notch (p = 0.001) in the S-I direction.

Conclusions
Mandibular midline landmarks and chin peripheral regions contribute significantly to overall facial asymmetry characteristics. Despite significant correction after bimaxillary surgery, asymmetry persisted at several sites, thereby requiring secondary correction. Comprehensive 3D presurgical planning is central for asymmetry correction in a single surgery.

Clinical relevance
The present study specifies the location of residual asymmetry sites and advocates the correction of those sites during initial surgery.
Lightlike and ideal tetrahedra
Authors: Meusburger Catherine , Scarinci Carlos 
Published: March 2022

AbstractWe give a unified description of tetrahedra with lightlike faces in 3d anti-de Sitter, de Sitter and Minkowski spaces and of their duals in 3d anti-de Sitter, hyperbolic and half-pipe spaces. We show that both types of tetrahedra are determined by a generalized cross-ratio with values in a commutative 2d real algebra that generalizes the complex numbers. Equivalently, tetrahedra with lightlike faces are determined by a pair of edge lengths and their duals by a pair of dihedral angles. We prove that the dual tetrahedra are precisely the generalized ideal tetrahedra introduced by Danciger. Finally, we compute the volumes of both types of tetrahedra as functions of their edge lengths or dihedral angles, obtaining generalizations of the Milnor–Lobachevsky volume formula of ideal hyperbolic tetrahedra.
Why does thermomagnetic resonance affect cancer growth? A non-equilibrium thermophysical approach
Authors: Grisolia Giulia , Lucia Umberto 
Published: March 2022

AbstractRecently, the low frequency thermomagnetic effects on cancer cells have been analysed, both theoretically and experimentally. They have been explained by introducing an equilibrium thermodynamic approach. But, in this context, two related open problems have been highlighted: (1) Does there exist a magnetic interaction or do there exist any other processes? (2) Do there exist also thermal effects? Here, we introduce a non-equilibrium thermodynamic approach in order to address an answer to these questions. The results obtained point out that: (a) the effect produced by the electromagnetic wave is just a consequence of the interaction of the magnetic component of the electromagnetic wave with the biological matter; (b) the interaction of the electromagnetic wave causes also thermal effects, but related to heat transfer, even if there have been applied low frequency electromagnetic waves; (c) the presence of the magnetic field generates a symmetry breaking in the Onsager’s coefficients, with a related perturbation of the cancer stationary state.
The effects of a restorative justice programme (Halt) on educational outcomes and recidivism of young people
Authors: Vooren Melvin , Rud Iryna , Cornelisz Ilja , Van Klaveren Chris , Groot Wim , Maassen van den Brink Henriëtte 
Published: March 2022

Abstract
Objectives
This study examines the effects of a restorative justice programme in the Netherlands on educational outcomes and repeated delinquent behaviour of young people who have committed a criminal offence.

Methods
We use data from a field experiment, in which the participants are randomly assigned to a restorative justice programme. We link the data from the field experiment to longitudinal administrative data on education and criminal records and correct for selective attrition by implementing an instrumental variable approach.

Results
The results show that participation in the restorative justice programme increases the probability of recidivism one year after the programme by 39.3 percent from a base rate of 17.1 percent and decreases tertiary educational attainment by 29.1 percent from a base rate of 30.9 percent.

Conclusions
Altogether, the results of this study suggest that despite the design backed by criminological and sociological theory, a restorative punishment from the Halt programme does not succeed in reducing criminal involvement and improving the educational outcomes.
The association of circadian parameters and the clustering of fatigue, depression, and sleep problems in breast cancer survivors: a latent class analysis
Authors: de Rooij Belle H. , Ramsey Imogen , Clouth Felix J. , Corsini Nadia , Heyworth Jane S. , Lynch Brigid M. , Vallance Jeff K. , Boyle Terry 
Published: March 2022

Abstract

Purpose
Circadian rhythms control a wide range of physiological processes and may be associated with fatigue, depression, and sleep problems. We aimed to identify subgroups of breast cancer survivors based on symptoms of fatigue, insomnia, and depression; and assess whether circadian parameters (i.e., chronotype, amplitude, and stability) were associated with these subgroups over time.

Methods
Among breast cancer survivors, usual circadian parameters were assessed at 3–4 months after diagnosis (T0), and symptoms of fatigue, depression, and insomnia were assessed after 2–3 years (T1, N = 265) and 6–8 years (T2, N = 169). We applied latent class analysis to classify survivors in unobserved groups (“classes”) based on symptoms at T1. The impact of each of the circadian parameters on class allocation was assessed using multinomial logistic regression analysis, and changes in class allocation from T1 to T2 using latent transition models.

Results
We identified 3 latent classes of symptom burden: low (38%), moderate (41%), and high (21%). Survivors with a late chronotype (“evening types”) or low circadian amplitude (“languid types”) were more likely to have moderate or high symptom burden compared to “morning types” and “vigorous types,” respectively. The majority of survivors with moderate (59%) or high (64%) symptom burden at T1 had persistent symptom burden at T2.

Implications for Cancer Survivors
A late chronotype and lower circadian amplitude after breast cancer diagnosis were associated with greater symptoms of fatigue, depression, and insomnia at follow-up. These circadian parameters may potentially be novel targets in interventions aimed at alleviating symptom burden among breast cancer survivors.
ADSC-Exosomes Alleviate MTX-induced Rat Neuronal Damage by Activating Nrf2-ARE Pathway
Authors: Huang Tingting , Tong Hongfei , Zhou Haixia , Wang Juxiang , Hu Linglong , Wang Yao , Huang Zhen 
Published: March 2022

AbstractThe aim of this study was to analyze the efficacy and underlying mechanism of adipose-derived mesenchymal stem cell exosome (ADSC-exosomes)–mediated protection on methotrexate (MTX)–induced neuronal damage. We established a H2O2­induced oxidative stress model in vitro, as well as an MTX-induced neuronal damage rat model in vivo. We analyzed the effects of ADSC-exosomes on neuronal damage and Nrf2-ARE signaling pathway in rats and related mechanisms. The morphological and functional recovery of rat hippocampal neurons by ADSC-exosomes was examined by Nissl staining and modified neurological severity score (mNSS) score. The activation of Nrf2-ARE pathway effectively inhibited H2O2-induced oxidative stress. ADSC-exosomes treatment restored the activity of hippocampal neuronal cells, reduced ROS production, and inhibited hippocampal neuronal cells apoptosis. In in vivo experiments, ADSC­exosomes ameliorates MTX-induced hippocampal neuron damage by triggering Nrf2­ARE pathway, decreasing IL-6, IFN-, and TNF-a levels and TUNEL positive cells in hippocampus, and repairing hippocampal neuronal cell damage. ADSC­exosomes ameliorated MTX-induced neuronal damage and suppressed oxidative stress induced by neuronal damage through the activation of Nrf2-ARE signaling pathway.
Ecotourism risk assessment in Yaoluoping Nature Reserve, Anhui, China based on GIS
Authors: Tang Xuehai , Wu Yanping , Ye Jun , Lv Haiyan , Sun Feixia , Huang Qingfeng 
Published: March 2022

AbstractAs tourism development and human disturbance increase, they have been affecting the functional structure distribution, sustainable utilization of resources, and ecological benefits of nature reserves. At the same time, ecological risk has increased significantly. This study proposes ecotourism development patterns for risk areas at each level, to provide a basis for stabilizing and promoting the ecological sustainable development of nature reserves. Yaoluoping National Nature Reserve in China is used as a study case. Based on GaoFen-2 satellite data within the reserve area in 2017, ENVI, Fragstats and ArcGIS10.2 are used for land use classification as well as evaluation indicators selection and analysis. The ecotourism risk assessment model of the reserve is constructed, which is also imbedded with analytic hierarchy process and Ecological Risk Index. The model consists of landscape ecology, topographic hydrology, land use and human activities factors, and it can produce the distribution map at the ecotourism risk level of the reserve. Results show that the high ecotourism risk areas in the reserve are mainly located around rivers and roads, and they are distributed in strips. Overall, the ecotourism risk level in the northern part of the reserve is higher than that in the southern part. Nearly 90% of the regional ecotourism risk is at the middle or low level, implying the reserve in a healthy level overall. However, except for low-risk areas, the proportion of risk areas at all levels in the core zone is higher than that in the buffer zone.
User-Focused Monitoring as a Strategy for Involvement and Mental Health Service Development: An Analysis of Swedish Monitoring Reports
Authors: Näslund Hilda , Grim Katarina , Markström Urban 
Published: March 2022

AbstractUser-focused monitoring (UFM) is a method of evaluating mental health services, conducted by people with lived experience of mental ill health. Research on UFM and on user involvement focused on service monitoring and evaluation is lacking. This study addresses this knowledge gap by examining UFM as a strategy for user involvement. More specifically, this study aims to synthesize patterns in UFM reports to characterize the phenomenon, as well as to further discuss negotiation processes and political opportunities in UFM. The empirical material consists of 136 Swedish UFM reports that have been analyzed in two steps: All reports were mapped according to general characteristics and a sample of 20 reports were selected to provide additional information on the method. This study has been conducted in collaboration with actors representing the user movement and municipality-based mental health services. Our analysis shows that long-term contracts between user organizations and service providers are important to create a sustainable implementation of UFM. However, strategies to protect user autonomy must be carefully considered and employed in relation to such collaborations. We further highlight the risks of a restricted focus on consumer satisfaction, and discuss the current development towards including follow-ups in the UFM process as a strategy for counteracting tokenism.
Innovation, income, and waste disposal operations in Korea: evidence from a spectral granger causality analysis and artificial neural networks experiments
Authors: Mele Marco , Magazzino Cosimo , Schneider Nicolas , Gurrieri Antonia Rosa , Golpira Hêriş 
Published: March 2022

AbstractThe aim of this paper is to assess the causal relationship among innovation in environment-related technologies, per capita income, and three major waste disposal operations (landfill, recycling, and incineration) for Korea. A time-series analysis over the frequency domain (Breitung–Candelon Spectral Granger causality) is applied, followed by Artificial Neural Networks experiments over the 1985–2016 period. Empirical results highlight that economic growth is tightly linked both to the growth of recycled waste and to the increase of environment-related innovations. Findings also highlight that waste recycling operations can spur the level of economic activity.
Target residence of Cas9: challenges and opportunities in genome editing
Authors: Feng Yi-Li , Wang Meng , Xie An-Yong 
Published: March 2022

AbstractCRISPR/Cas9 genome editing is a latest success in biotechnology that repurposes a natural biological system for a practical tool in genetic engineering. Site-specific DNA double strand breaks (DSB) induced by the CRISPR nuclease Cas9 allows endogenous cellular repair apparatus to generate desired repair products. Residence of Cas9 on cleaved DNA conceals the DNA ends from recognition by response and repair apparatus, delaying DNA damage response (DDR) and repair. Thus, tight-binding and long residence of Cas9 on DNA target are proposed as a new determinant of DSB repair pathway choice and may collaborate with other endogenous pathway choice regulators to control DSB repair. Accordingly, harnessing the binding and resident behavior of Cas9 not only broadens the application of CRISPR/dCas9 platform, which at least in part depends upon the tight binding and long residence of dCas9, but also minimizes the undesired outcomes of CRISPR/Cas9 genome editing.