bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erythrocytes from patients with ST-elevation myocardial infarction induce cardioprotection through the purinergic P2Y13 receptor and nitric oxide signaling
Authors: Jiao Tong , Collado Aida , Mahdi Ali , Jurga Juliane , Tengbom John , Saleh Nawzad , Verouhis Dinos , Böhm Felix , Zhou Zhichao , Yang Jiangning , Pernow John 
Published: September 2022

AbstractRed blood cells (RBCs) are suggested to play a role in cardiovascular regulation by exporting nitric oxide (NO) bioactivity and ATP under hypoxia. It remains unknown whether such beneficial effects of RBCs are protective in patients with acute myocardial infarction. We investigated whether RBCs from patients with ST-elevation myocardial infarction (STEMI) protect against myocardial ischemia–reperfusion injury and whether such effect involves NO and purinergic signaling in the RBCs. RBCs from patients with STEMI undergoing primary coronary intervention and healthy controls were administered to isolated rat hearts subjected to global ischemia and reperfusion. Compared to RBCs from healthy controls, RBCs from STEMI patients reduced myocardial infarct size (30 ± 12% RBC healthy vs. 11 ± 5% RBC STEMI patients, P < 0.001), improved recovery of left-ventricular developed pressure and dP/dt and reduced left-ventricular end-diastolic pressure in hearts subjected to ischemia–reperfusion. Inhibition of RBC NO synthase with L-NAME or soluble guanylyl cyclase (sGC) with ODQ, and inhibition of cardiac protein kinase G (PKG) abolished the cardioprotective effect. Furthermore, the non-selective purinergic P2 receptor antagonist PPADS but not the P1 receptor antagonist 8PT attenuated the cardioprotection induced by RBCs from STEMI patients. The P2Y13 receptor was expressed in RBCs and the cardioprotection was abolished by the P2Y13 receptor antagonist MRS2211. By contrast, perfusion with PPADS, L-NAME, or ODQ prior to RBCs administration failed to block the cardioprotection induced by RBCs from STEMI patients. Administration of RBCs from healthy subjects following pre-incubation with an ATP analog reduced infarct size from 20 ± 6 to 7 ± 2% (P < 0.001), and this effect was abolished by ODQ and MRS2211. This study demonstrates a novel function of RBCs in STEMI patients providing protection against myocardial ischemia–reperfusion injury through the P2Y13 receptor and the NO–sGC–PKG pathway.
Time-dependent contact mechanics
Authors: de León Manuel , Gaset Jordi , Gràcia Xavier , Muñoz-Lecanda Miguel C. , Rivas Xavier 
Published: September 2022

AbstractContact geometry allows us to describe some thermodynamic and dissipative systems. In this paper we introduce a new geometric structure in order to describe time-dependent contact systems: cocontact manifolds. Within this setting we develop the Hamiltonian and Lagrangian formalisms, both in the regular and singular cases. In the singular case, we present a constraint algorithm aiming to find a submanifold where solutions exist. As a particular case we study contact systems with holonomic time-dependent constraints. Some regular and singular examples are analyzed, along with numerical simulations.
Accuracy of different approaches for detecting proximal root caries lesions in vitro
Authors: Göstemeyer Gerd , Preus Mareike , Elhennawy Karim , Schwendicke Falk , Paris Sebastian , Askar Haitham 
Published: September 2022

Abstract

Objectives
The objective was to evaluate the diagnostic accuracy of radiographic evaluation (XR), visual-tactile assessment (VT), laser-fluorescence (LF) (DIAGNOdent Pen/KaVo), and near-infrared-light transillumination (NILT) (DIAGNOcam/KaVo) on proximal root caries lesions in vitro.

Methods
Two-hundred extracted permanent premolars and molars with and without proximal root caries lesions were allocated to 50 diagnostic models simulating the proximal contacts between teeth and mounted in a phantom dummy head. Two independent examiners used the diagnostic approaches to detect any or advanced root caries lesions, with histologic evaluation of the lesions serving as reference. Receiver operating characteristic (ROC) curves were employed, and sensitivity, specificity, and the area under the ROC curve (AUC) are calculated. Significant differences in mean AUCs between approaches were assumed if p < 0.05 (two-sample t-test).

Results
NILT was not applicable for proximal root caries detection. The sensitivity/specificity to detect any lesions was 0.81/0.63 for XR, 0.76/0.88 for VT and 0.81/0.95 for LF, and the sensitivity/specificity to detect advanced lesions was 0.43/0.94 for XR, 0.66/0.99 for VT, and 0.83/0.78 for LF, respectively. For both, any and advanced root caries lesions, mean AUCs for LF and VT were significantly higher compared to XR (p < 0.05). For any root caries lesions, LF was significantly more accurate than VT (p = 0.01), but not for advanced root caries lesions (p = 0.59).

Conclusions
Under the in vitro conditions chosen, LF and VT were more accurate than XR to detect proximal root caries lesions, with LF being particularly useful for initial lesion stages.

Clinical relevance
LF might be a useful diagnostic aid for proximal root caries diagnosis. Clinical studies are necessary to corroborate the findings.
Ubiquitous mitochondrial creatine kinase promotes the progression of gastric cancer through a JNK-MAPK/JUN/HK2 axis regulated glycolysis
Authors: Mi Yushuai , Li Quanhui , Liu Bingtian , Wang Dehai , Liu Ziping , Wang Tianshi , Wang Yuan , Zang Yifeng , Zhou Yan , Wen Yugang , Ding Yinlu 
Published: September 2022

Abstract
Background
Ubiquitous mitochondrial creatine kinase (uMtCK) transfers high-energy phosphates from mitochondrially generated ATP to creatine to generate phosphocreatine. uMtCK overexpression has been reported in several malignant tumors, however, the clinical significance and impact of uMtCK in gastric cancer (GC) has not been comprehensively studied.

Methods
We first examined uMtCK expression in GC by quantitative real-time PCR and western blot assays. Then the clinicopathological significance of aberrant uMtCK expression was determined by immunohistochemical staining in a GC tissue microarray. Kaplan–Meier analysis was used for survival analysis. The biological functions of uMtCK in GC cells were explored by wound-healing, transwell assays and glucose metabolism assays in vitro as well as a liver metastasis model by spleen injection in nude mice in vivo.

Results
We verified that the expression of uMtCK was substantially elevated in GC tissues, significantly associating with a poorer prognosis in GC patients, especially for those with advanced stage. In univariate and multivariate analyses, uMtCK expression emerged as an independent prognostic factor for both disease-free survival and overall survival. Functionally, we demonstrated that uMtCK promoted glycolysis in GC cells and facilitated their migration, invasion and liver metastasis in vitro and in vivo. Mechanistically, uMtCK enhanced GC progression in a HK2-dependent glycolysis via acting the JNK-MAPK/JUN signaling pathway.

Conclusions
uMtCK could serve as a novel independent prognostic biomarker as well as potential therapeutic target for GC patients, particularly for GC patients with an advanced UICC stage and tumor recurrence.
Autarkie und Offenheit — Überlegungen zur optimalen Balance einer offenen Volkswirtschaft
Authors: Petersen Thieß , Wortmann Marcus 
Published: September 2022

ZusammenfassungNach einem Globalisierungsschub im Zuge des Falls des Eisernen Vorhangs und von Chinas Beitritt zur WTO wurde die internationale Arbeitsteilung in den vergangenen Jahren stärker von protektionistischen Tendenzen geprägt. Die Unterbrechungen der grenzüberschreitenden Lieferkettenbeziehungen während der Coronapandemie und des Ukrainekriegs stärken zudem den Wunsch nach einer Reduzierung der Export- und insbesondere der Importabhängigkeit. Es ist zu diskutieren, wie man theoretisch zum optimalen Offenheitsgrad einer Volkswirtschaft gelangt und damit auch ein ideales Ausmaß der ökonomischen Autarkie bestimmt.
Die Ausschreibung als ungeeignetes Verfahren zur Vergabe von Mobilfunkfrequenzen
Authors: Bulowski Stefan , Kühling Jürgen , Zierke Oliver 
Published: September 2022

ZusammenfassungMit der zum 1. Dezember 2021 in Kraft getretenen Novelle des Telekommunikationsgesetzes (TKG) ist der Vorrang der Versteigerung als Regelvergabeverfahren für Frequenzen bei Knappheit aufgehoben worden. Das TKG sieht zwei mögliche Vergabeverfahren für Frequenzen bei Knappheit vor: die Versteigerung und die Ausschreibung. Im Gesetzestext des neuen TKG heißt es, dass dasjenige Vergabeverfahren durchzuführen ist, das die Erreichung der Regulierungsziele des Gesetzes am besten gewährleistet. Im Fall der Vergabe von knappen Mobilfunkfrequenzen ist das Ausschreibungsverfahren für die Erreichung von Regulierungszielen wie Effizienz und Transparenz jedoch generell ungeeignet.
Securing federated learning with blockchain: a systematic literature review
Authors: Qammar Attia , Karim Ahmad , Ning Huansheng , Ding Jianguo 
Published: September 2022

AbstractFederated learning (FL) is a promising framework for distributed machine learning that trains models without sharing local data while protecting privacy. FL exploits the concept of collaborative learning and builds privacy-preserving models. Nevertheless, the integral features of FL are fraught with problems, such as the disclosure of private information, the unreliability of uploading model parameters to the server, the communication cost, etc. Blockchain, as a decentralized technology, is able to improve the performance of FL without requiring a centralized server and also solves the above problems. In this paper, a systematic literature review on the integration of Blockchain in federated learning was considered with the analysis of the existing FL problems that can be compensated. Through carefully screening, most relevant studies are included and research questions cover the potential security and privacy attacks in traditional federated learning that can be solved by blockchain as well as the characteristics of Blockchain-based FL. In addition, the latest Blockchain-based approaches to federated learning have been studied in-depth in terms of security and privacy, records and rewards, and verification and accountability. Furthermore, open issues related to the combination of Blockchain and FL are discussed. Finally, future research directions for the robust development of Blockchain-based FL systems are proposed.
Enveloping Algebras of Krichever-Novikov Algebras are not Noetherian
Authors: Buzaglo Lucas 
Published: September 2022

AbstractThis work is part of the overarching question of whether it is possible for the universal enveloping algebra of an infinite-dimensional Lie algebra to be noetherian. The main result of this paper is that the universal enveloping algebra of any Krichever-Novikov algebra is not noetherian, extending a result of Sierra and Walton on the Witt (or classical Krichever-Novikov) algebra. As a subsidiary result, which may be of independent interest, we show that if ${\mathfrak {h}}$
h
is a Lie subalgebra of ${\mathfrak {g}}$
g
of finite codimension, then the noetherianity of U$U({\mathfrak {h}})$
U
(
h
)
is equivalent to the noetherianity of U$U({\mathfrak {g}})$
U
(
g
)
. The second part of the paper focuses on Lie subalgebras of W≥− 1 = Der(𝕜[t]). In particular, we prove that certain subalgebras of W≥− 1 (denoted by L(f), where f ∈ 𝕜[t]) have non-noetherian universal enveloping algebras, and provide a sufficient condition for a subalgebra of W≥− 1 to have a non-noetherian universal enveloping algebra. Furthermore, we make significant progress on a classification of subalgebras of W≥− 1 by showing that any infinite-dimensional subalgebra must be contained in some L(f) in a canonical way.
Same sensitivity with shorter exposure: behavior as an appropriate parameter to assess metal toxicity
Authors: Alonso Álvaro , Romero-Blanco Alberto 
Published: September 2022

AbstractThe exposure of animals to toxicants may cause a depletion in the energy uptake, which compromises reproduction and growth. Although both parameters are ecologically relevant, they usually need long-term bioassays. This is a handicap for the availability of toxicological data for environmental risk assessment. Short-term bioassays conducted with environmental concentrations, and using relevant ecological parameters sensitive to short-term exposures, such as behavior, could be a good alternative. Therefore, to include this parameter in the risk assessment procedures, it is relevant the comparison of its sensitivity with that of growth and reproduction bioassays. The study aim was the assessment of differences between endpoints based on mortality, behaviour, reproduction, and growth for the toxicity of metals on aquatic animals. We used the ECOTOX database to gather data to construct chemical toxicity distribution (CTD) curves. The mean concentrations, the mean exposure time, and the ratio between the mean concentration and the exposure time were compared among endpoints. Our results showed that behavioral, growth, and reproduction bioassays presented similar sensitivity. The shortest exposure was found in behavioral and reproduction bioassays. In general, the amount of toxicant used per time was lower in growth and reproduction bioassays than in behavioral and mortality bioassays. We can conclude that, for metal toxicity, behavioral bioassays are less time-consuming than growth bioassays. As the sensitivity of behavior was similar to that of growth and reproduction, this endpoint could be a better alternative to longer bioassays.
TROMPA-MER: an open dataset for personalized music emotion recognition
Authors: Gómez-Cañón Juan Sebastián , Gutiérrez-Páez Nicolás , Porcaro Lorenzo , Porter Alastair , Cano Estefanía , Herrera-Boyer Perfecto , Gkiokas Aggelos , Santos Patricia , Hernández-Leo Davinia , Karreman Casper , Gómez Emilia 
Published: September 2022

AbstractWe present a platform and a dataset to help research on Music Emotion Recognition (MER). We developed the Music Enthusiasts platform aiming to improve the gathering and analysis of the so-called “ground truth” needed as input to MER systems. Firstly, our platform involves engaging participants using citizen science strategies and generate music emotion annotations – the platform presents didactic information and musical recommendations as incentivization, and collects data regarding demographics, mood, and language from each participant. Participants annotated each music excerpt with single free-text emotion words (in native language), distinct forced-choice emotion categories, preference, and familiarity. Additionally, participants stated the reasons for each annotation – including those distinctive of emotion perception and emotion induction. Secondly, our dataset was created for personalized MER and contains information from 181 participants, 4721 annotations, and 1161 music excerpts. To showcase the use of the dataset, we present a methodology for personalization of MER models based on active learning. The experiments show evidence that using the judgment of the crowd as prior knowledge for active learning allows for more effective personalization of MER systems for this particular dataset. Our dataset is publicly available and we invite researchers to use it for testing MER systems.
Higher-order recurrence relations, Sobolev-type inner products and matrix factorizations
Authors: Hermoso Carlos , Huertas Edmundo J. , Lastra Alberto , Marcellán Francisco 
Published: September 2022

AbstractIt is well known that Sobolev-type orthogonal polynomials with respect to measures supported on the real line satisfy higher-order recurrence relations and these can be expressed as a (2N + 1)-banded symmetric semi-infinite matrix. In this paper, we state the connection between these (2N + 1)-banded matrices and the Jacobi matrices associated with the three-term recurrence relation satisfied by the standard sequence of orthonormal polynomials with respect to the 2-iterated Christoffel transformation of the measure.
Precise prediction of optical behaviour of mechanically stressed edge emitting GaAs devices
Authors: Hildenstein P. , Feise D. , Ostermay I. , Paschke K. , Tränkle G. 
Published: September 2022

AbstractThe presence of a thermally annealed metallization layer on top of a GaAs slab waveguide proofed to be of strong impact on the optical device behavior. Induced by the stress on the chip the elasto-optical effect imprinted a strong variation on the refractive index that led to anti-guiding and guiding effects. In order to enable precise prediction of the optical behavior we present a 3D mechanical device simulation which provides detailed insights to the overall stress state. The results are then used in a 2D in-house developed optical simulation that allows precise analysis of the microscopic optical behavior. Therefore, the accumulated stress effects are represented by an effective temperature difference between semiconductor and metallization, which allows a strong simplification of the model setup. The results are validated by comparison to the experimental derived data. As the simulation proves to be highly accurate, the stress load on the device can be calculated vice versa from the optical behavior.
Using software visualization to support the teaching of distributed programming
Authors: Di Rocco Lorenzo , Ferraro Petrillo Umberto , Palini Francesco 
Published: September 2022

AbstractIn this paper, we introduce MARVEL, a system designed to simplify the teaching of MapReduce, a popular distributed programming paradigm, through software visualization. At its core, it allows a teacher to describe and recreate a MapReduce application by interactively requesting, through a graphical interface, the execution of a sequence of MapReduce transformations that target an input dataset. Then, the execution of each operation is illustrated on the screen by playing an appropriate graphical animation stage, highlighting aspects related to its distributed nature. The sequence of all animation stages, played back one after the other in a sequential order, results in a visualization of the whole algorithm. The content of the resulting visualization is not simulated or fictitious, but reflects the real behavior of the requested operations, thanks to the adoption of an architecture based on a real instance of a distributed system running on Apache Spark. On the teacher’s side, it is expected that by using MARVEL he/she will spend less time preparing materials and will be able to design a more interactive lesson than with electronic slides or a whiteboard. To test the effectiveness of the proposed approach on the learner side, we also conducted a small scientific experiment with a class of volunteer students who formed a control group. The results are encouraging, showing that the use of software visualization guarantees students a learning experience at least equivalent to that of conventional approaches.
Common Humanity as an Under-acknowledged Mechanism for Mental Health Peer Support
Authors: Kotera Yasuhiro , Llewellyn-Beardsley Joy , Charles Ashleigh , Slade Mike 
Published: September 2022

AbstractMental health peer support (PS) is a relational approach to recovery. Service users are helped through a relationship focused on connection with a PS worker who shares similar experiences. Despite the strong evidence base, the mechanisms of action for mental health PS are under-researched. Several theories have been proposed to explain the mechanisms, including social comparison theory (SCT). SCT highlights the benefits arising from emphasising differences between a service user and the PS worker. An unintended consequence is that connection between them may be reduced. We propose common humanity (CH) as an under-acknowledged mechanism of action. CH is an experience recognising that there are other people living with similar suffering, and helps us regulate emotions. A CH-informed connection-based PS relationship may help a service user in different ways from a SCT-informed comparison-based PS relationship. Future PS research can investigate emotional self-regulation to establish whether CH-related outcomes arise from PS.
Service Leadership through Serving Minority
Adolescents in Rural China Using a Rural Version of a Positive Youth Development
Program
Authors: Zhou Zheng , Mu Liping , Qi Shaojie , Shek Daniel T.L. 
Published: September 2022

AbstractWith the emerging service economy globally, nurturing university
students to be service leaders possessing the leadership qualities of competence,
character and care is of great importance. Through service-learning (SL), the
academic learning of the students on Service Leadership can be consolidated. In the
present study, we piloted a SL subject on Service Leadership in a university in the
Southwestern part of China. After learning the basic academic knowledge on Service
Leadership, seven students provided service for the Yi minority adolescents in
Liangshan using the rural version of the program. To understand the impact of SL on
the service recipients, a single group pretest-posttest design was used to assess
the changes in Yi minority adolescents (N = 79) before and after they
received the service. We also conducted subjective outcome evaluation of the service
providers (the university students providing the service) and service recipients (Yi
adolescents). Results showed that the service recipients had significant positive
changes in the outcome indicators and they had positive perceptions of the program.
The qualitative evaluation findings are also encouraging. The findings provide
evidence supporting the use of SL in nurturing service leadership qualities in
university students in mainland China.
Business-Civil Society Collaborations in South Korea: A Multi-Stage Pattern Matching Study
Authors: Sinkovics Noemi , Kim Jihye , Sinkovics Rudolf R. 
Published: September 2022

AbstractIn this study, we use an empirical example to demonstrate how a multi-stage pattern matching process can inform and substantiate the construction of partial least squares (PLS) models and the subsequent interpretation of and theorizing from the findings. We document the research process underlying our empirical investigations of business – civil society collaborations in South Korea. The four-step process we outline in this paper can be used to ensure the meaningfulness of the structural model as well as to maximize the use of PLS for theorizing. This methodological advancement is particularly helpful in situations when literature reference points exist, but further contextual information may add nuances to prevalent knowledge. The findings from the qualitative flexible pattern matching part of the study prompted us to conduct a multi-group analysis. The resulting path changes in the base model led to the identification of four partnering strategies for business-CSO collaborations: (1) partnering for visibility; (2) partnering for compliance; (3) partnering for responsibility outsourcing; and (4) partnering for value co-creation.