bluuebunny/crossref_metadata_2025_split huggingface dataset:
“I think it's something that we should lean in to”: The use of OpenNotes in Canadian psychiatric care contexts by clinicians
Authors: Kassam Iman , Shin Hwayeon Danielle , Durocher Keri , Lo Brian , Shen Nelson , Mehta Rohan , Sockalingam Sanjeev , Wiljer David , Gratzer David , Sequeira Lydia , Strudwick Gillian 
Published: December 2022

Background OpenNotes is the concept of patients having access to their health records and clinical notes in a digital form. In psychiatric settings, clinicians often feel uncomfortable with this concept, and require support during implementation. Objective This study utilizes an implementation science lens to explore clinicians’ perceptions about using OpenNotes in Canadian psychiatric care contexts. The findings are intended to inform the co-design of implementation strategies to support the implementation of OpenNotes in Canadian contexts. Method This qualitative descriptive study employed semi-structured interviews which were completed among health professionals of varying disciplines working in direct care psychiatric roles. Data analysis consisted of a qualitative directed content analysis using themes outlined from an international Delphi study of mental health clinicians and experts. Ethical approval was obtained from the Centre for Addiction and Mental Health and the University of Toronto. Results In total, 23 clinicians from psychiatric settings participated in the interviews. Many of the themes outlined within the Delphi study were voiced. Benefits included enhancements to patient recall, and empowerment, improvements to care quality, strengthened relational effects and effects on professional autonomy and efficiencies. Despite the anticipated benefits of OpenNotes, identified challenges pertained to clarity surrounding exemption policies, training on patient facing notes, managing disagreements, and educating patients on reading clinical notes. Conclusion Many benefits and challenges were identified for adopting OpenNotes in Canadian psychiatric settings. Future work should focus on applying implementation frameworks to develop interventions that address the identified challenges.
Pedicle Screw-Associated Violation of the Adjacent Unfused Facet Joint: Clinical Outcomes and Fusion Rates
Authors: Sinz Nathan J. , Hwang Raymond W. , Lee Gyu-Ho , Baker Kevin C. , Arnold Paul , Sasso Rick , Park Daniel , Fischgrund Jeffrey , Niu Ruijia , Kim David H. 
Published: December 2022

Study Design Retrospective review of a prospective randomized trial. Objectives To compare outcome scores and fusion rates in patients with and without pedicle screw-associated facet joint violation (FJV) after a single-level lumbar fusion. Methods Clinical outcomes data and computed tomography (CT) imaging were reviewed for 157 patients participating in a multicenter prospective trial. Post-operative CT scans at 12-months follow-up were examined for fusion status and FJV. Patient-reported outcomes (PROs) included Oswestry Disability Index (ODI) and Visual Analog Scale (VAS) for leg and low back pain. Chi-square test of independence was used to compare proportions between groups on categorical measures. Two-sample t-test was used to identify differences in mean patient outcome scores. Logistic regression models were performed to determine association between FJV and fusion rates. Results Of the 157 patients included, there were 18 (11.5%) with FJV (Group A) and 139 (88.5%) without FJV (Group B). Patients with FJV experienced less improvement in ODI (P = .004) and VAS back pain scores (P = .04) vs patients without FJV. There was no difference in mean VAS leg pain (P = .4997). The rate of fusion at 12-months for patients with FJV (27.8%) was lower compared to those without FJV (71.2%) (P = .0002). Patients with FJV were 76% less likely to have a successful fusion at 12-months. Conclusion Pedicle screw-associated violation of the adjacent unfused facet joint during single-level lumbar fusion is associated with less improvement in back pain, back pain-associated disability, and a lower fusion rate at 1-year after surgery.
Assessment of the Ulnar Collateral Ligament of the Elbow Using Ultrasonic Shear Wave Elastography in Professional Baseball Players
Authors: Yoshikawa Tomoya , Inui Atsuyuki , Mifune Yutaka , Nishimoto Hanako , Yamaura Kohei , Mukohara Shintaro , Shinohara Issei , Hoshino Yuichi , Matsuishita Takehiko , Kuroda Ryosuke 
Published: December 2022

Background: Injury to the ulnar collateral ligament (UCL) of the elbow can cause chronic pain and loss of throwing ability. Ultrasonic shear wave elastography (SWE) is a new imaging method that can be used for quantitative assessment of tissue elasticity. Purpose: To evaluate the properties of the UCL in professional baseball players using SWE. Study Design: Cross-sectional study; Level of evidence, 3. Methods: This study included 35 professional baseball players (mean age, 23.0 years) without elbow injuries. Both elbows of each player were examined using ultrasound, and comparisons between the dominant and nondominant arms were conducted. The thickness of the anterior bundle of the UCL at its midportion was measured in the resting position on ultrasound. We also measured the difference in the ulnohumeral joint space with and without gravity stress on the forearm. Tissue elasticity was evaluated using a built-in software program. The relationship between UCL elasticity and ultrasound findings was analyzed using the Pearson correlation coefficient. Results: The mean ± SD thickness of the UCL was significantly greater in the dominant arm versus the nondominant arm (6.0 ± 1.4 vs 5.3 ± 1.3 mm; P = .004). The mean joint space difference was significantly wider in the dominant arm as compared with the nondominant arm (0.81 ± 0.42 vs 0.52 ± 0.31 mm; P = .002), and the mean UCL elasticity was lower in the dominant arm than in the nondominant arm (34.9 ± 11.6 vs 43.3 ± 10.6 kPa; P = .002). UCL elasticity was negatively correlated with UCL thickness ( r = –0.27; P = .02) and joint space difference ( r = –0.34; P = .003). Conclusion: In professional baseball players, the elbow UCL of the dominant arm demonstrated increased thickness, with a larger joint space gap on gravity stress and lower elasticity in SWE as compared with the nondominant arm. Greater medial joint laxity can be predicted by assessing the elasticity of the UCL using SWE.
Osteointegration of PLLA/β-TCP Biocomposite Anchors Used in Coracoid Transfer Procedures for Shoulder Instability: Quantitative Computed Tomography With a Minimum 2-Year Follow-up
Authors: Shen Guangsi , Ma Yinguang , Zhang Shuhan , Song Qingfa , Tang Chengyang , Zhang Yaxuan , Liu Guihu , Liu Qiang , Shao Zhenxing , Cui Guoqing 
Published: December 2022

Background: Biocomposite anchors have been a popular choice for use in coracoid transfer procedures for shoulder instability and are hypothesized to allow bone ingrowth. Purpose: To quantitatively evaluate the osteointegration of 85% PLLA/15% β-TCP biocomposite anchors used in the coracoid transfer procedure for shoulder instability. Study Design: Case series; Level of evidence, 4. Methods: We performed a retrospective case series of abstracted data from the records of 74 patients who underwent coracoid transfer procedures with biocomposite anchors. Computed tomography was performed at 24 months postoperatively. A total of 4 researchers independently reviewed the computed tomography images. The density (in Hounsfield unit [HU] values) of the anchor tunnels, glenoid, and subscapularis was assessed, and osteointegration of the anchor tunnels was evaluated with HU values, the quantitative ossification quality score (QOQS), and tunnel widening. Results: Included were 74 patients (58 male, 16 female), involving 76 shoulders and 124 biocomposite anchors. At ≥24-month follow-up, 72 of 124 (58.06%) anchor tunnels were classified as QOQS type 1, including 12 completely ossified tunnels and 60 almost completely ossified tunnels. Some degree of ossification (QOQS types 1-3) was observed in 118 (95.16%) anchor tunnels. Overall, 3 anchor tunnels were enlarged (QOQS type 5). The mean HU value of the anchor tunnels was 339.75, which was significantly higher than the preoperative HU value of the glenoid vault (262.19). Among the 124 anchor tunnels, 79 had HU values higher than their glenoid HU values, and 45 had lower HU values than their glenoid HU values. In the comparison of tunnel HU values at 12 versus ≥24 months, the HU value at ≥24 months was significantly higher. A total of 20 anchor tunnels widened. Conclusion: Among 124 anchor tunnels, 95.16% showed ossification, 58.06% were completely or nearly completely ossified, and 3 were enlarged. The HU value of the anchor tunnel increased over time.
Cross-sectional Survey Examining Patient Attitudes and Preferences for Rescheduling Screening Colonoscopies Canceled due to the COVID-19 Pandemic
Authors: Valentine K. D. , Leavitt Lauren , Atlas Steven J. , Chen Emily , Ha Jasmine , Percac-Lima Sanja , Fairfield Kathleen M. , Korsen Neil , Han Paul K. J. , Richter James M. , Simmons Leigh , Sepucha Karen R. 
Published: December 2022

Background. Early in the COVID-19 pandemic colonoscopies for colorectal cancer (CRC) screening were canceled. Patient perceptions of the benefits and risks of routine screening relative to health concerns associated with the COVID-19 pandemic were unknown. Purpose. Assess patient anxiety, worry, and interest in CRC screening during the COVID-19 pandemic. Methods. A random sample of 200 patients aged 45 to 75 y with colonoscopy cancellation due to COVID-19 in March to May 2020 were surveyed. Anxiety, COVID-19 and CRC risk perceptions, COVID-19 and CRC worry, likelihood of following through with colonoscopy in the next month, and interest in alternatives to colonoscopy were assessed. Subsequent screening was tracked for 12 mo. Results. Respondents ( N = 127/200, 63.5%) were on average 60 y old, female (59%), college educated (62% college degree or more), and White (91%). A substantial portion of patients (46%) stated they may not follow through with a colonoscopy in the next month. There was greater interest in stool-based testing than in delaying screening (48% v. 26%). Women, older patients, and patients indicating tolerance of uncertainty due to complexity reported they were less likely to follow through with colonoscopy in the next month. Greater interest in stool-based testing was related to lower perceptions of CRC risk. Greater interest in delaying screening was related to less worry about CRC and less tolerance of risk. Over 12 mo, 60% of participants completed screening. Patients who stated they were more likely to screen in the next month were more likely to complete CRC screening ( P = 0.01). Conclusions. Respondents who had a colonoscopy canceled during the COVID-19 pandemic varied in interest in rescheduling the procedure. A shared decision-making approach may help patients address varying concerns and select the best approach to screening for them. Highlights In the wake of the first wave of the COVID-19 pandemic, almost half of patients stated they were not likely to follow through with a colonoscopy in the short term, about half were interested in screening with a stool-based test, and only one-quarter were interested in delaying screening until next year. Patients who perceived themselves at higher risk of colorectal cancer were less interested in stool-based testing, and patients who were more worried about colorectal cancer were less interested in delaying screening. A shared decision-making approach may be necessary to tailor screening discussions for patients during subsequent waves of the pandemic, other occasions where resources are limited and patient preferences vary, or where patients hold conflicting views of screening.
Technique for Reconstruction of the Proximal Tibiofibular Joint Using Biceps Femoris and Iliotibial Band Autograft With Suture Tape Augmentation
Authors: Burger Joseph M. , Sarac Nikolas , Miller Timothy 
Published: December 2022

Background: Proximal tibiofibular joint instability is an uncommon condition that can occur in acute traumatic dislocations, chronic or recurrent dislocations, and atraumatic dislocations. A variety of procedures have been described for treatment of this condition including fibular head resection, arthrodesis, suture button stabilization, and soft tissue reconstruction. Indications: The initial management consists of conservative measures such as activity modification, use of a supportive strap, and physical therapy. When nonoperative management fails, surgical management is indicated. Technique Description: To optimize surgical technique and patient outcomes, a previously described reconstruction technique was modified with reinforcement of suture tape augmentation and decreased invasiveness. Results: This technique has several advantages including a smaller incision with shorter iliotibial band (ITB) and biceps femoris tendon (BFT) grafts and safer posterior to anterior drilling as opposed to anterior to posterior directed drilling. Discussion/Conclusion: The authors believe there is increased stability with this reconstruction technique due to the added suture tape augmentation in addition to the biologic healing potential provided by the ITB and BFT autografts. The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
Diagnosis and management of pulmonary arterial hypertension
Authors: Cullivan Sarah , Higgins Margaret , Gaine Sean 
Published: December 2022

Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature that is characterised by elevated pressures within the pulmonary vascular tree. Recent decades have witnessed a dramatic expansion in our understanding of the pathobiology and the epidemiology of PAH, and improvements in treatment options and outcomes. The prevalence of PAH is estimated to be between 48 and 55 cases per million adults. The definition was recently amended and a diagnosis of PAH now requires evidence of a mean pulmonary artery pressure >20 mmHg, a pulmonary vascular resistance >2 Wood units and a pulmonary artery wedge pressure ≤15 mmHg at right heart catheterisation. Detailed clinical assessment and a number of additional diagnostic tests are required to assign a clinical group. Biochemistry, echocardiography, lung imaging and pulmonary function tests provide valuable information to assist in the assignment of a clinical group. Risk assessment tools have been refined, and these greatly facilitate risk stratification and enhance treatment decisions and prognostication. Current therapies target three therapeutic pathways: the nitric oxide, prostacyclin and endothelin pathways. While lung transplantation remains the only curative intervention for PAH, there are a number of promising therapies under investigation which may further reduce morbidity and improve outcomes.This review describes the epidemiology, pathology and pathobiology of PAH and introduces important concepts regarding the diagnosis and risk stratification of PAH. The management of PAH is also discussed, with a special focus on PAH specific therapy and key supportive measures.
Vertical niche differentiation of comammox Nitrospira in water-level fluctuation zone of the Three Gorges Reservoir, China
Authors: Ding Hang , Zhou Mingzhi , Wang Yuchun , Hu Mingming , Wen Jie , Li Shanze , Bao Yufei , Zhao Jianwei 
Published: December 2022

AbstractComammox (CMX) Nitrospira bacteria (NB) can accomplish ammonia oxidation independently, and their niche differentiation holds promise for their ecological and survival functions. In this work, the vertical niche differentiation of CMX NB was investigated in the soils of 6 water-level fluctuation (WLF) zones (both natural and artificial) in the Three Gorges Reservoir (TGR) region. The results demonstrated that the level of clade A amoA was obviously reduced with increasing soil depth in the natural WLF zones and one of the artificial WLF zones. However, in the other two artificial WLF zones, the abundance of this gene was not dramatically reduced with depth. The level of clade B amoA did not markedly decrease with increasing soil depth in most WLF zones and remained stable in the three WLF zones. Total nitrogen (TN) had the most significant effect on the abundance of CMX NB. Clade A.1, clade A.2.1, clade A.2.2, clade A.3, and clade B of CMX NB co-occurred simultaneously in all WLF zones. The number of operational taxonomic units (OTUs) of clade A in the two types of WLF zones first increased and then decreased with increasing depth, whereas the number of OTUs of clade B continuously increased with depth in the artificial WLF zone. Total carbon (TC) and pH, as environmental factors, affected the community structure of CMX NB. This study confirmed the vertical differentiation of the abundance and diversity of CMX NB in the WLF zones of the TGR region, and the artificial restoration of the WLF zones affected the niche differentiation of CMX NB to a certain degree.
Performance of several types of beta-binomial models in comparison to standard approaches for meta-analyses with very few studies
Authors: Felsch Moritz , Beckmann Lars , Bender Ralf , Kuss Oliver , Skipka Guido , Mathes Tim 
Published: December 2022

Abstract
Background
Meta-analyses are used to summarise the results of several studies on a specific research question. Standard methods for meta-analyses, namely inverse variance random effects models, have unfavourable properties if only very few (2 – 4) studies are available. Therefore, alternative meta-analytic methods are needed. In the case of binary data, the “common-rho” beta-binomial model has shown good results in situations with sparse data or few studies. The major concern of this model is that it ignores the fact that each treatment arm is paired with a respective control arm from the same study. Thus, the randomisation to a study arm of a specific study is disrespected, which may lead to compromised estimates of the treatment effect. Therefore, we extended this model to a version that respects randomisation.
The aim of this simulation study was to compare the “common-rho” beta-binomial model and several other beta-binomial models with standard meta-analyses models, including generalised linear mixed models and several inverse variance random effects models.

Methods
We conducted a simulation study comparing beta-binomial models and various standard meta-analysis methods. The design of the simulation aimed to consider meta-analytic situations occurring in practice.

Results
No method performed well in scenarios with only 2 studies in the random effects scenario. In this situation, a fixed effect model or a qualitative summary of the study results may be preferable. In scenarios with 3 or 4 studies, most methods satisfied the nominal coverage probability. The “common-rho” beta-binomial model showed the highest power under the alternative hypothesis. The beta-binomial model respecting randomisation did not improve performance.

Conclusion
The “common-rho” beta-binomial appears to be a good option for meta-analyses of very few studies. As residual concerns about the consequences of disrespecting randomisation may still exist, we recommend a sensitivity analysis with a standard meta-analysis method that respects randomisation.
SCARA5 induced ferroptosis to effect ESCC proliferation and metastasis by combining with Ferritin light chain
Authors: Liu Yanqun , Xiong Rong , Xiao Ting , Xiong Li , Wu Jialin , Li Junfeng , Feng Gang , Song Guiqin , Liu Kang 
Published: December 2022

Abstract
Background
Esophageal squamous cell carcinoma (ESCC) remains one of the most lethal cancers worldwide accompany with an extremely poor prognosis. Therefore, this study aims to screen for new molecules affecting ESCC and explore their mechanisms of action to provide ideas for targeted therapies for ESCC.

Methods
Firstly, we screened out the membrane protein SCARA5 by high-throughput sequencing of the ESCC patient tissues, and RT-qPCR and WB were used to verify the differential expression of SCARA5 in esophageal cell lines, and IHC analyzed the expression localization of SCARA5 in ESCC tissue. Then, flow cytometry, wound healing assay, Transwell assay and CCK-8 assay were used to explore the effects of SCARA5 on cell cycle, migration and invasion as well as cell proliferation activity of esophageal squamous carcinoma cells. Meanwhile, transmission electron microscopy was used to detect changes in cellular mitochondrial morphology, and flow cytometry were used to detect changes in intracellular reactive oxygen metabolism, and immunofluorescence and flow cytometry were used to detect changes in intracellular Fe2+. Mechanistically, co-immunoprecipitation was used to detect whether SCARA5 binds to ferritin light chain, and ferroptosis-related protein expression was detected by WB. Finally, the tumor xenograft model was applied to validation the role of SCARA5 tumor growth inhibition in vivo.

Results
We found that SCARA5 was aberrantly decreased in ESCC tissues and cell lines. Furthermore, we confirmed that SCARA5 suppressed the cell cycle, metastasis and invasion of ESCC cells. Meanwhile, we also found that overexpression of SCARA5 caused changes in mitochondrial morphology, accumulation of intracellular reactive oxygen species and increased intracellular Fe2+ in ESCC cells, which induced ferroptosis in ESCC cells. Mechanically, we validated that SCARA5 combined with ferritin light chain and increased intracellular Fe2+. As well as, overexpression SCARA5 induced ferroptosis by increasing ferritin light chain in nude mice subcutaneous tumors and inhibited the growth of nude mice subcutaneous tumors.

Conclusion
Collectively, our findings demonstrated that SCARA5 suppressed the proliferation and metastasis of ESCC by triggering ferroptosis through combining with ferritin light chain.
The Mini-SIPS: development of a brief clinical structured interview guide to diagnosing DSM-5 Attenuated Psychosis Syndrome and training outcomes
Authors: Woods Scott W. , Lympus Cole , McGlashan Thomas H. , Walsh Barbara C. , Cannon Tyrone D. 
Published: December 2022

Abstract
Objective
The Mini-SIPS, a condensed version of the Structured Interview for Psychosis-Risk Syndromes (SIPS), is intended to efficiently identify for clinicians the minimum information needed to support a DSM-5 Attenuated Psychosis Syndrome (APS) diagnosis.

Methods
The instrument and the DSM-5 criteria are accessible through the online training program.

Results
Most individuals (67.5%) in the first 212 to complete the training program indicated an intended use of the Mini-SIPS exclusively for clinical purposes. Performance on the post-training quiz was excellent for those with and without prior training in structured diagnostic interviewing.

Conclusion
The Mini-SIPS, and accompanying training program, are offered as public-domain clinical resources to the mental health community.