bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Guanosine‐Quadruplex Hydrogel as Cascade Reaction Container Consuming Endogenous Glucose for Infected Wound Treatment—A Study in Diabetic Mice
Authors: Li Yuanfeng , Su Linzhu , Zhang Yongxin , Liu Yong , Huang Fan , Ren Yijin , An Yingli , Shi Linqi , van der Mei Henny C. , Busscher Henk J. 
Published: January 2022

AbstractDiabetic foot ulcers infected with antibiotic‐resistant bacteria form a severe complication of diabetes. Antimicrobial‐loaded hydrogels are used as a dressing for infected wounds, but the ongoing rise in the number of antimicrobial‐resistant infections necessitates new, nonantibiotic based designs. Here, a guanosine‐quadruplex (G4)‐hydrogel composed of guanosine, 2‐formylphenylboronic acid, and putrescine is designed and used as a cascade‐reaction container. The G4‐hydrogel is loaded with glucose‐oxidase and hemin. The first cascade‐reaction, initiated by glucose‐oxidase, transforms glucose and O2 into gluconic acid and H2O2. In vitro, this reaction is most influential on killing Staphylococcus aureus or Pseudomonas aeruginosa in suspension, but showed limited killing of bacteria in biofilm‐modes of growth. The second cascade‐reaction, however, transforming H2O2 into reactive‐oxygen‐species (ROS), also enhances killing of biofilm bacteria due to hemin penetration into biofilms and interaction with eDNA G‐quadruplexes in the biofilm matrix. Therewith, the second cascade‐reaction generates ROS close to the target bacteria, facilitating killing despite the short life‐time of ROS. Healing of infected wounds in diabetic mice proceeds faster upon coverage by these G4‐hydrogels than by clinically common ciprofloxacin irrigation. Moreover, local glucose concentrations around infected wounds decrease. Concluding, a G4‐hydrogel loaded with glucose‐oxidase and hemin is a good candidate for infected wound dressings, particularly in diabetic patients.
Amidoxime Group‐Anchored Single Cobalt Atoms for Anti‐Biofouling during Uranium Extraction from Seawater
Authors: Sun Wenyan , Feng Lijuan , Zhang Jiacheng , Lin Ke , Wang Hui , Yan Bingjie , Feng Tiantian , Cao Meng , Liu Tao , Yuan Yihui , Wang Ning 
Published: January 2022

AbstractMarine biofouling is one of the most significant challenges hindering practical uranium extraction from seawater. Single atoms have been widely used in catalytic applications because of their remarkable redox property, implying that the single atom is highly capable of catalyzing the generation of reactive oxygen species (ROS) and acts as an anti‐biofouling substance for controlling biofouling. In this study, the Co single atom loaded polyacrylamidoxime (PAO) material, PAO‐Co, is fabricated based on the binding ability of the amidoxime group to uranyl and cobalt ions. Nitrogen and oxygen atoms from the amidoxime group stabilize the Co single atom. The fabricated PAO‐Co exhibits a broad range of antimicrobial activity against diverse marine microorganisms by producing ROS, with an inhibition rate up to 93.4%. The present study is the first to apply the single atom for controlling biofouling. The adsorbent achieves an ultrahigh uranium adsorption capacity of 9.7 mg g−1 in biofouling‐containing natural seawater, which decreased only by 11% compared with that in biofouling‐removed natural seawater. These findings indicate that applying single atoms would be a promising strategy for designing biofouling‐resistant adsorbents for uranium extraction from seawater.
Wheat nitrogen response conditional on past yield and rainfall: A step in improving optimal nitrogen applications
Authors: Mills Brian E. , Brorsen B. Wade , Tostão Emilio , Biermacher Jon T. 
Published: January 2022

AbstractMaking precision nitrogen (N) application clearly profitable will likely require incorporating multiple sources of information. Low‐cost sources of information include rainfall and the previous year's yield. This paper uses data from a long‐term experiment on the response of winter wheat (Triticum aestivum L.) to N fertilizer, as well as rainfall data from the University of Oklahoma's Mesonet weather station. The goal was to determine optimal topdress levels of N. A regression was used to determine the previous year's yield and rainfall on the marginal product of farmer‐applied N. Information from lagged yield and rainfall increases profit by $2.79 ha–1. Therefore, lagged yield and rainfall could be a low‐cost information source to add to other sources of information to achieve the goal of widespread adoption of precision N application.
Site‐specific effects of winter cover crops on soil water storage
Authors: Nichols Virginia A. , Moore E. Britt , Gailans Stefan , Kaspar Thomas C. , Liebman Matt 
Published: January 2022

AbstractAddition of an overwintering cereal rye (Secale cereale L.) cover crop (CC) to midwestern maize (Zea mays L.)‐based systems offers several environmental benefits, but the long‐term effects of this practice on soil hydrological properties are not well understood. We utilized four long‐term (10+ yr) trials (two commercial fields, two research plots) in Iowa that included a replicated winter rye CC and no‐cover treatment in no‐till maize/soybean [Glycine max (L.) Merr.] systems. We took intact 7.62‐cm diam. soil samples from a 10‐to‐18‐cm depth shortly after cash crop planting in the spring. We measured the soil water retention curve using matric potentials ranging from saturation to –500 cmH2O. In addition, we measured organic matter, textural composition, and bulk densities of the soil samples. At the depth sampled, CCs did not meaningfully affect bulk density, water contents at saturation, or air‐entry potentials at any trial, nor increase the percentage of macropores. At two trials, soil water content at field capacity (–100 cmH2O) in the CC treatments was 2.5 vol% (SE: 1.2%; commercial field) and 2.4 vol% (SE: 1.3%; research plot) higher compared with the no‐cover treatments. This increase could meaningfully reduce the amount of water drained from a field after a saturating rain and should be considered when assessing CC impacts on landscape hydrology. The presence or absence of a CC effect on field capacity was not related to CC aboveground biomass production, previous cash crop, or soil texture at the trial sites. Based on our results, a causal model, and previous literature we hypothesize CC root characteristics are key to understanding variable effects of CCs on soil water storage. Our results indicate it is possible for CCs to meaningfully affect soil water storage, but more research is needed on the mechanisms by which these changes occur.
Method validation, residue analysis and dietary risk assessment of trifloxystrobin and trifloxystrobin acid in milk, eggs and pork
Authors: Bi Yingying , Han Lijun , Qin Fayi , Song Shuangyu , Lv Xinru , Dong Qin , Qiao Chengkui , Ren Bo 
Published: January 2022

AbstractTrifloxystrobin (TFS) is a widely used strobilurin fungicide and its residues accumulating in animal‐derived food could result in potential harm to consumers. By optimization of extraction solvents and cleanup sorbents, a residue analysis method for TFS and its metabolite trifloxystrobin acid (TFSA) was established in milk, eggs and pork based on QuEChERS sample preparation and LC–MS/MS. The calibration curves exhibited good linearity with determination coefficients (R2) >0.9930 over the range of 0.5–250 ng/ml for both TFS and TFSA. The recoveries of the two analytes were 81–100% with RSD 3–10% and 76–96% with RSD 2–13%, respectively. The limit of quantification (LOQ) was 1 ng/g for both analytes. The milk, egg and pork samples, 30 each, were collected from the 30 main producing regions in China, and residues of TFS and TFSA were analyzed. The concentrations of both analytes were lower than the corresponding LOQs and maximum residue limits. Long‐term dietary risk assessment showed that the hazard quotients were 0.001–0.003%, indicating an absence of unacceptable risks in milk, eggs and pork to the health of common consumers in China.
Coping strategies and mental health in a sample of students accessing a university counselling service
Authors: Buizza Chiara , Cela Herald , Costa Andrea , Ghilardi Alberto 
Published: January 2022

AbstractThe aim of this study was to evaluate the coping strategies used by college students and their association with socio‐demographic characteristics and distress. The sample was composed of 219 students, who had previously accessed the university counselling service over a 5‐year period. The Symptom Checklist‐90‐Revised, the General Health Questionnaire‐12 and the Brief COPE Inventory were administered. Results showed that male students tended to use more active strategies than female students and that students studying health‐related subjects presented less distress than those studying technical subjects. Moreover, the results indicated that the self‐blame coping strategy is a major predictor of mental health issues and that interaction between age and area of study aggravated the symptomatology. Further research is needed to better understand the experience of distress from the college students' perspective, and to identify what interventions are really effective in supporting students to cope with distress.
A chemogenomic approach is required for effective treatment of amyotrophic lateral sclerosis
Authors: Pampalakis Georgios , Angelis Georgios , Zingkou Eleni , Vekrellis Kostas , Sotiropoulou Georgia 
Published: January 2022

AbstractALS is a fatal untreatable disease involving degeneration of motor neurons. Μultiple causative genes encoding proteins with versatile functions have been identified indicating that diverse biological pathways lead to ALS. Chemical entities still represent a promising choice to delay ALS progression, attenuate symptoms and/or increase life expectancy, but also gene‐based and stem cell‐based therapies are in the process of development, and some are tested in clinical trials. Various compounds proved effective in transgenic models overexpressing distinct ALS causative genes unfortunately though, they showed no efficacy in clinical trials. Notably, while animal models provide a uniform genetic background for preclinical testing, ALS patients are not stratified, and the distinct genetic forms of ALS are treated as one group, which could explain the observed discrepancies between treating genetically homogeneous mice and quite heterogeneous patient cohorts. We suggest that chemical entity‐genotype correlation should be exploited to guide patient stratification for pharmacotherapy, that is administered drugs should be selected based on the ALS genetic background.
The biological properties of the decellularized tracheal scaffolds and 3D printing biomimetic materials: A comparative study
Authors: Pan Shu , Lu Yi , Li Jianfeng , Shi Hongcan 
Published: January 2022

AbstractThe construction of ideal tissue engineering trachea has always been a difficult problem in trachea transplantation surgery. The biological characteristics of decellularized matrix prepared by detergent‐enzymatic (DEM) and 3D printing biomimetic scaffold (PTS) in vivo and in vitro were compared. In order to comprehensively evaluate its performance, we tested morphological and biomechanical characteristics of the native tracheas(Group A), DEM(Group B), and PTS(Group C). The above groups were co‐cultured with bone marrow mesenchymal stem cells (BMSCs), after which cell attachment and proliferation on the scaffolds were detected. Allogeneic implantation experiments were performed to assess the in vivo biocompatibility of the studied scaffolds. Moreover, an in‐situ experiment of the tracheal repair was conducted to compare the survival of every group. The biomechanical properties of PTS were significantly better than those of other scaffolds (P < .05). And they retained their structural integrity in the host compared with the other scaffolds (P < .05). Besides, significantly milder immune‐rejection reactions were observed in Group C than those in Group A (P < .05). In situ experiments showed that Group C significantly a good postoperative condition compared with the other scaffold groups (P < .05). Fiberoptic bronchoscopy analysis of PTS showed a better condition in the lumen. In conclusion, PTS has excellent biomechanical properties. Although the PTS group showed lower biocompatibility than the decellularized group, it exhibited better cell attachment and proliferation. In situ transplantation results showed that PTS could be an ideal source of tissue engineering material for tracheal repair.
Product cones in dense pairs
Authors: Eleftheriou Pantelis E. 
Published: January 2022

AbstractLet be an o‐minimal expansion of an ordered group, and a dense set such that certain tameness conditions hold. We introduce the notion of a product cone in , and prove: if expands a real closed field, then admits a product cone decomposition. If is linear, then it does not. In particular, we settle a question from [10].
Synchronization in a two‐supplier assembly system: Combining a fixed lead‐time module with capacitated make‐to‐order production
Authors: Meijer Mirjam Susanne , van Jaarsveld Willem , de Kok Ton 
Published: January 2022

AbstractA high‐tech manufacturer often produces products that consist of many modules. These modules are either sourced from one of its suppliers or produced in‐house. In this paper, we study the common case of an assembly system in which one module is sourced from a supplier with a fixed lead‐time, while the other module is produced by the manufacturer itself in a make‐to‐order production system. Since unavailability of one of the modules has costly consequences for the production of the end‐product, it is important to coordinate between the ordering policy for one module and the production of the other. We propose an order policy for the lead‐time module with base‐stock levels depending on the number of outstanding orders in the production system of the in‐house produced module. We prove monotonicity properties of this policy and show optimality. Furthermore, we conduct a computational experiment to evaluate how the costs of this policy compare to those of a policy with fixed base‐stock levels and show that average savings of up to 17% are attained.
The Impact of Felony Diversion in San Francisco
Authors: Augustine Elsa , Lacoe Johanna , Raphael Steven , Skog Alissa 
Published: January 2022

AbstractIn the traditional criminal justice system, an arrest is followed by multiple decision points determining detention, prosecution, guilt, and sentence. Many jurisdictions across the U.S. are exploring alternative programs and approaches that consider individual needs and assessed risks at each decision point. San Francisco County, California, uses post‐filing pretrial diversion programs as alternatives to the traditional criminal justice system for defendants based on factors including social and behavioral needs. In this paper, we estimate the impact of a referral to felony pretrial diversion programs on case outcomes and subsequent criminal justice contact. To address selection bias associated with nonrandom assignment into diversion programs, we exploit the random assignment of felony cases to arraignment judges and use variation among judicial diversion referral rates as an instrument for the diversion referral. We find that a referral to diversion increases the time to disposition in the current case and decreases the probability of a subsequent conviction up to five years following case arraignment. Subgroup analyses find that the benefits of diversion are concentrated among females, those who are under the age of 25, and those facing drug sales charges.
Anchoring modified polystyrene to boron nitride nanosheets as highly thermal conductive composites for heat dissipation
Authors: Han Weifang , Chu Xiaohan , Li Yongwei , Xu Ziping , Li Wei , Fu Peng , Li Yuchao , Zhang Xinwei , Jia Zhengfeng , Zhang Xiangdong 
Published: January 2022

AbstractEnhancing the heat dissipation capacity of polymer‐based composites requires effectively improving the compatibility of filler in a polymer matrix. Herein, hydroxylated boron nitride (BN‐OH) and modified polystyrene (mPS) are combined to achieve a high thermal conductive BN‐OH@mPS composite by using a facile in‐situ polymerization. Due to the strong interface interaction between BN‐OH and mPS, the proposed BN‐OH@mPS composite can have high thermal conductivity (TC). Specifically, the TC of the composite containing 10 wt% BN‐OH can reach 1.231 W/mK, which is 142% higher than that of BN/PS manufactured by a traditional method. Additionally, such a special structure brings a delayed decomposition process of the composite, making it possess high thermal stability. Overall, this serves as a universal route for developing thermal conductive non‐polar polymer/inorganic filler composites.
Playing Quantum Nonlocal Games with Six Noisy Qubits on the Cloud
Authors: Sheffer Meron , Azses Daniel , Dalla Torre Emanuele G. 
Published: January 2022

AbstractNonlocal games are extensions of Bell inequalities, aimed at demonstrating quantum advantage. These games are well suited for noisy quantum computers because they only require the preparation of a shallow circuit, followed by the measurement of non‐commuting observable. Here, the minimal implementation of the nonlocal game proposed in Science 362, 308 (2018) is considered. This game is tested by preparing a 6‐qubit cluster state using quantum computers on the cloud by IBM, IonQ, and Honeywell. The present implementation includes several levels of optimization, such as circuit identities and error mitigation, and allows us to cross the classical threshold and demonstrate quantum advantage in one quantum computer. The quantum nature of the cluster state is further studied by a Bell inequality that allows us to observe quantum advantage in less accurate quantum computers, at the expense of probing a larger number of circuits.
ISTSat‐1, a space‐based Automatic Dependent Surveillance‐Broadcast demonstration CubeSat mission
Authors: Monteiro João P. , Cunha Alberto , Silva Alexandre , Fernandes Carlos , Neves Diogo , Naf Fabian , Tavares Gonçalo , Freitas José , Pinto João , Piedade Moisés , Ramos Nuno , Gil Paulo J. S. , Macedo Paulo , Afonso Rúben , Encarnação Renato , Ramos Rodrigo , Almeida Tomás , Rocha Rui M. 
Published: January 2022

SummaryThe use of space‐based Automatic Dependent Surveillance‐Broadcast (ADS‐B) receivers to extend aircraft surveillance beyond line‐of‐sight communication has been discussed since the late 2000s and has been demonstrated in various missions. Although recent demonstrations have relied on small CubeSat platforms, the use of the smallest possible form factor has not been explored. This paper describes development of a spacecraft representing the first use of a 1 U CubeSat platform for aircraft tracking. To comply with the platform's limited power budget, the receiver departs from the typical application of FPGA boards to decoding ADS‐B signals and instead employs a general microprocessor. The spacecraft also features some innovations over traditional CubeSat platforms, such as distributed system‐level software amenable to extensive code reuse, redundant communications mechanisms, and software‐based radiation mitigation strategies. Having designed, built, and integrated all subsystems, as well as performed multiple test campaigns at system and subsystem level, the team now aims at completing formal functional and environmental testing before undergoing the launch campaign, foreseen for 2022.
Multiple imputation for longitudinal data using Bayesian lasso imputation model
Authors: Yamaguchi Yusuke , Yoshida Satoshi , Misumi Toshihiro , Maruo Kazushi 
Published: January 2022

AbstractMultiple imputation is a promising approach to handle missing data and is widely used in analysis of longitudinal clinical studies. A key consideration in the implementation of multiple imputation is to obtain accurate imputed values by specifying an imputation model that incorporates auxiliary variables potentially associated with missing variables. The use of informative auxiliary variables is known to be beneficial to make the missing at random assumption more plausible and help to reduce uncertainty of the imputations; however, it is not straightforward to pre‐specify them in many cases. We propose a data‐driven specification of the imputation model using Bayesian lasso in the context of longitudinal clinical study, and develop a built‐in function of the Bayesian lasso imputation model which is performed within the framework of multiple imputation using chained equations. A simulation study suggested that the Bayesian lasso imputation model worked well in a variety of longitudinal study settings, providing unbiased treatment effect estimates with well‐controlled type I error rates and coverage probabilities of the confidence interval; in contrast, ignorance of the informative auxiliary variables led to serious bias and inflation of type I error rate. Moreover, the Bayesian lasso imputation model offered higher statistical powers compared with conventional imputation methods. In our simulation study, the gains in statistical power were remarkable when the sample size was small relative to the number of auxiliary variables. An illustration through a real example also suggested that the Bayesian lasso imputation model could give smaller standard errors of the treatment effect estimate.
Cancellation mechanism of dark matter direct detection in Higgs-portal and vector-portal models
Authors: Cai Chengfeng , Zeng Yu-Pan , Zhang Hong-Hao 
Published: January 2022

Abstract
We present two alternative proofs for the cancellation mechanism in the U(1) symmetric pseudo-Nambu-Goldstone-Boson Dark Matter (pNGB DM) model. They help us to have a better understanding of the mechanism from multi-angle, and inspire us to propose some interesting generalizations. In the first proof, we revisit the non-linear representation method and rephrase the argument with the interaction eigenstates. In this picture, the phase mode (DM) can only have a trilinear interaction with a derivative-squared acting on the radial mode when the DM is on-shell. Thus, the DM-quark scattering generated by a mass mixing between the radial mode and the Higgs boson vanishes in the limit of zero-momentum transfer. Using the same method, we can easily generalize the model to an SO(N) model with general soft-breaking structures. In particular, we study the soft-breaking cubic terms and identify those terms which preserve the cancellation mechanism for the DM candidate. In our discussion of the second method, we find that the cancellation relies on the special structure of mass terms and interactions of the mediators. This condition can be straightforwardly generalized to the vector-portal models. We provide two examples of the vector-portal case where the first one is an SU(2)L × U(1)Y × U(1)X model and the second one is an SU(2)L × U(1)Y × U(1)B−L × U(1)X model. In the first model the vector mediators are the Zμ boson and a new U(1)X gauge boson Xν, while in the second model the mediators are the U(1)B−L and U(1)X gauge bosons. The cancellation mechanism works in both models when there are no generic kinetic mixing terms for the gauge bosons. Once the generic kinetic mixing terms are included, the first model requires a fine-tuning of the mixing parameter to avoid the stringent direct detection bound, while the second model can naturally circumvent it.
The Log of Gravity at 15
Authors: Santos Silva J. M. C. , Tenreyro Silvana 
Published: January 2022

AbstractWe review the contribution of “The Log of Gravity” (Santos Silva and Tenreyro, Rev Econ Stat 88:641–658, 2006), summarize the main results in the ensuing literature, and provide a brief review of the state-of-the-art in the estimation of gravity equations and other constant-elasticity models.