bluuebunny/crossref_metadata_2025_split huggingface dataset:
política de tierras y colonización en Chaco durante el Plan Trienal (1973-1976): planificación y análisis para un campo en transformación
Authors: Almirón Adrián Alejandro 
Published: September 2022

La política de colonización durante la década del setenta en el Chaco ocupó un lugar preponderante, en especial durante el segundo gobierno de Deolindo Bittel entre los años 1973-1976. Estas medidas se relacionaban al denominado Plan Trienal planificado por el tercer gobierno de Juan Domingo Perón, las cuales buscaban promover la productividad agrícola y fortalecer la expansión de las áreas extrapampeanas. De esta forma, el artículo plantea analizar la reconstrucción de los proyectos de colonización diseñados por el Estado nacional y provincial. Estudiaremos el rol de las instituciones y de los expertos en la formulación y en los trabajos realizados en el territorio a fin de lograr cambios en el agro chaqueño.
Estudio de las necesidades de capacitación del entrenador empresarial en hoteles del destino turístico de Varadero.
Authors: Del Toro Soto Maithé del Toro Soto , Jiménez Valero Bisleivys , Velastegui López Luis Efraín 
Published: September 2022

La capacitación del entrenador empresarial repercute en el desarrollo de las organizaciones. El propósito del siguiente estudio consiste en identificar las necesidades del entrenador empresarial en hoteles del destino turístico de Varadero. Como escenario propicio se seleccionó un hotel de cada grupo hotelero (Cubanacán, Gran Caribe e Islazul). Para ello se empleó una encuesta de elaboración propia que contiene datos generales ocho preguntas, donde, las respuestas son de marcaje rápido y sencillo. Los resultados del diagnóstico muestran las dificultades en las acciones de capacitación para contribuir al desempeño exitoso de los entrenadores empresariales. Las debilidades más señaladas se inscriben en lo referido a la, la metodología de la enseñanza, el dominio de técnicas participativas, la actualización de los sistemas de conocimientos, las habilidades con las TIC. Presentan insuficiencias también en lo relativo a la participación en cursos de capacitación, en actividades metodológicas y en la participación en eventos. Dentro de las fortalezas se encuentran la formación inicial para el cumplimiento de sus funciones y los años de experiencia profesional de los trabajadores.
PENINGKATAN PENGUASAAN KOSA KATA BAHASA INGGRIS MELALUI METODE PERMAINAN WORD SEARCH GAME DI SISWA KELAS VIII SMPN 4 KOTA TERNATE
Authors: Garwan Suryani , Jusnita Naniek 
Published: September 2022

The aim of this research is to know the improvement of word search game method that can increase student‘s English vocabulary acquisition. This research was used Classroom Action Research (CAR) which was done in three circles, each circle explained preparation, action, observation and reflection step. Data sources are students, peers, researchers, documents. The results word search game with method steps: (1) prepare a word search game, (2) Game rules, (3) Divide the group, (4) Division of word search game, (5) the time restriction, (6) Doing word search game, (7) Correcting the work, (8) giving evalution, (9) reward. In the assessmen to flearning out comes increased 100%.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE THINK PAIR SHARE UNTUK MENINGKATKAN HASIL BELAJAR BAHASA INDONESIA PADA KONSEP MEMBACA PEMAHAMAN SISWA KELAS V SD INPRES LABUHA
Authors: Togubu Ina , Somadayo Samsu , Pamuti Pamuti 
Published: September 2022

This study aims to determine the increase in learning outcomes of students in class V SD Inpres Labuha on the concept of reading comprehension by applying the cooperative learning model of the Think Pair Share type and to determine the activities of teachers and students when implementing the type of cooperative learning model Think Pair Share in grade V SD students. Labuha's Inpres on the concept of reading comprehension. The type of research used is Classroom Action Research (PTK). The research was conducted on the fifth-grade students of SD Inpres Labuha. The subjects of the research were 14 students of class V SD Inpres Labuha. The observer consists of two teachers, each with one teacher observing the activities of the teacher and another teacher observing the activities of students in the learning process. The techniques used in this research are test and non-test techniques. The test technique was used to determine student learning outcomes by using questions in the form of essays totaling 4 questions in cycle I and 4 questions in cycle II with a maximum score of 16. both classically and individually. The learning process that has been implemented is in accordance with the learning model Think Pair Share, starting from the stage Think (thinking individually), the stage Pair (pairing with a peer), the stage Share (sharing answers with other partners) can be carried out well by researchers and students class V SD Inpres Labuha. After being analyzed using descriptive statistics, it was found that an increase in student learning outcomes in class V SD Inpres Labuha through the cooperative learning model Think Pair Share on the concept of reading comprehension and the number of students who completed classical learning in the first cycle there were 8 students or 57%, in the second cycle, it increased. to 13 students or 92%, the results of observations on student activity increased by an average of 63% in the first cycle and 77% in the second cycle, while the results of teacher activity observations increased from 85% in the first cycle to 92% in the second cycle.
Biodiversity conservation and carbon storage of Acacia catechu willd. Dominated northern tropical dry deciduous forest ecosystems in north-western Himalaya: Implications of different forest management regimes
Authors: Kumar Dhirender , Thakur C. L. , Bhardwaj D. R. , Sharma Nidhi , Sharma Prashant , Sankhyan Neeraj 
Published: September 2022

Sustainable forest management is the key to biodiversity conservation, flow of resources and climate change mitigation. We assessed the impact of various forest management regimes (FMRs): legal felling series [(reserve forest (RF), demarcated protected forest (DPF), un-demarcated protected forest (UPF), co-operative society forest (CSF) and un-classed forest (UF)] on biodiversity conservations and carbon storage in Acaciacatechu Willd. Dominated northern tropical dry deciduous forest ecosystems in Nurpur Forest Division of north-western Himalaya, India. The study revealed significant variations in floristic composition, biodiversity indices, population structure and C storage potential among different forest management regimes. The RF and DPF were found to be rich in species diversity and richness whereas the Simpson dominance index for trees and shrubs was maximum in UF and UPF, respectively. The diversity of understory herbs were higher in CSF and UF. The maximum density of seedlings, saplings and poles were recorded in RF followed by DPF and UPF, whereas the minimum density was found in CSF. The tree C density (69.15 Mg C ha−1) was maximum in UF closely followed by RF; whereas the minimum was recorded in CSF (33.27 Mg C ha−1). The soil C density was maximum in RF (115.49 Mg C ha−1) and minimum in CSF (90.28 Mg C ha−1). Similarly, the maximum total ecosystem C density was recorded in RF (183.52 Mg C ha−1) followed by DPF (166.61 Mg C ha−1) and minimum in CSF (126.05 Mg C ha−1). Overall, UF management regimes were shown to have a greater capacity for C storage in vegetation, whereas strict FMRs, such as RF and DPF, were found to be more diverse and have a higher soil and ecosystem carbon density. The study established that in the midst of climate and biodiversity emergencies, it is urgent to maintain, protect and strengthen the network of RF and DPF FMRs for biodiversity conservation, climate change adaptation and mitigation.
Prevalence, indications, and outcomes of operative vaginal deliveries among mothers who gave birth in Ethiopia: A systematic review and meta-analysis
Authors: Balis Bikila , Debella Adera , Ketema Indeshaw , Eshetu Bajrond , Zerihun Ebisa , Deressa Wayesa Alemayehu , Habte Sisay , Alemu Adisu , Bekele Habtamu 
Published: September 2022

BackgroundOperative vaginal deliveries represent an alternative to address problems during the second stage of labor. Clinicians have access to two different instruments obstetrics forceps and vacuum which should be conducted with indication. Understanding the pooled prevalence of operative vaginal deliveries, its indications, and outcomes would help in adopting suitable measures to reduce operative vaginal deliveries-related maternal and neonatal complications. Therefore, this systematic review and meta-analysis aimed to determine the prevalence, indications, and outcomes of operative vaginal deliveries among mothers who gave birth in Ethiopia.MethodsA literature search was done through databases such as PubMed, SCOPUS, Web of Sciences, CAB Abstract, and CINHAL (EBSCO) to search studies that have been conducted in Ethiopia. Relevant sources were consulted to retrieve unpublished studies. Original observational studies that reported the prevalence, indication and outcomes of operative vaginal deliveries conducted in the English language were identified and screened. Studies were independently assessed for inclusion, data extraction, and risk of bias.ResultsTwelve studies were reviewed. The overall pooled prevalence of operative vaginal delivery among mothers who gave birth in Ethiopia was 10% (95% CI: 8 to 13) with I2 = 98.82% and a p-value ≤ 0.001. Fetal distress, prolonged labor, and maternal exhaustion were the most common feto-maternal indications of OVDs whereas; neonatal death, poor Apgar score, admission to neonatal intensive care unit, perianal tear, and postpartum hemorrhage were complications that occur following the operative vaginal deliveries in Ethiopia.ConclusionThis systematic review and meta-analysis showed one out of 10 mothers undergo operative vaginal deliveries. Almost all feto-maternal complications that arise following operative vaginal deliveries were preventable. Thus, concerned stakeholders should encourage quality OVDs practice by avoiding unnecessary indications and scaling up the skill of health professionals through special training.Systematic review registrationhttp://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022311432.
Population pharmacokinetic models of anti-PD-1 mAbs in patients with multiple tumor types: A systematic review
Authors: Shang Jingyuan , Huang Lin , Huang Jing , Ren Xiaolei , Liu Yi , Feng Yufei 
Published: September 2022

Aims and backgroundA number of population pharmacokinetic (PPK) models of anti-programmed cell death-1 (PD-1) monoclonal antibodies (mAbs) in multiple tumor types have been published to characterize the influencing factors of their pharmacokinetics. This review described PPK models of anti-PD-1 mAbs that investigate the magnitude and types of covariate effects in PK parameters, provide a reference for building PPK models of other anti-PD-1 mAbs, and identify areas requiring additional research to facilitate the application of PPK models.MethodsA systematic search for analyses of PPK models of eleven anti-PD-1 mAbs on the market that were carried out in humans was conducted using PubMed, Embase, and the Cochrane Library. The search covered the period from the inception of the databases to April 2022.ResultsCurrently, there are fourteen analyses on PPK models of anti-PD-1 mAbs summarized in this review, including seven models that refer to nivolumab, four referring to pembrolizumab, one referring to cemiplimab, one referring to camrelizumab, and one referred to dostarlimab. Most analyses described the pharmacokinetics of anti-PD-1 mAbs with a two-compartment model with time-varying clearance (CL) and a sigmoidal maximum effect. The estimated CL and volume of distribution in the central (VC) ranged from 0.179 to 0.290 L/day and 2.98 to 4.46 L, respectively. The median (range) of interindividual variability (IIV) for CL and VC was 30.9% (8.7%–50.8%) and 29.0% (4.32%–40.7%), respectively. The commonly identified significant covariates were body weight (BW) on CL and VC, and albumin (ALB), tumor type, sex, and performance status (PS) on CL. Other less assessed significant covariates included lactate dehydrogenase (LDH), immunoglobulin G (IgG), ipilimumab coadministration (IPICO) on CL, and body mass index (BMI), malignant pleural mesothelioma (MESO) on VC.ConclusionThis review provides detailed information about the characteristics of PPK models of anti-PD-1 mAbs, the effects of covariates on PK parameters, and the current status of the application of the models. ALB, BW, specific tumor type, sex, and PS should be considered for the future development of the PPK model of anti-PD-1 mAbs. Other potential covariates that were assessed less frequently but still have significance (e.g., LDH, IgG, and IPICO) should not be ignored. Thus, further research and thorough investigation are needed to assess new or potential covariates, which will pave the way for personalized anti-PD-1 mAbs therapy.
Complement activation in Hidradenitis suppurativa: Covert low-grade inflammation or innocent bystander?
Authors: van Straalen K. R. , Dudink K. , Aarts P. , van der Zee H. H. , van den Bosch T. P. P. , Giang J. , Prens E. P. , Damman J. 
Published: September 2022

Hidradenitis suppurativa (HS) is a chronic auto-inflammatory skin disease with a complex and multifactorial pathogenesis involving both the innate and adaptive immune system. Despite limited evidence forlocalcomplement activation, conflicting results have been published on the role ofsystemiccomplement activation in HS. It was hypothesized that complement was consumed in highly inflamed HS skin, trapping complement from the circulation. Therefore, the aim of this study was to evaluate thislocalcomplement deposition in HS skin lesions using routine and commonly used complement antibodies.Direct immunofluorescence for C1q, C3c, C4d, C5b-9, and properdin was performed on frozen tissue sections of 19 HS patients and 6 controls. C5a receptor 1 (C5aR1) was visualized using immunohistochemistry.Overall, we found no significant local complement deposition in HS patients versus controls regarding C1q, C3c, C4d, C5b-9, or properdin on either vessels or immune cells. C5aR1 expression was exclusively found on immune cells, predominantly neutrophilic granulocytes, but not significantly different relatively to the total infiltrate in HS lesions compared with controls. In conclusion, despite not being able to confirm local complement depositions of C1q, C3c, C4d, or properdin using highly sensitive and widely accepted techniques, the increased presence of C5aR1 positive immune cells in HS suggests the importance of complement in the pathogenesis of HS and supports emerging therapies targeting this pathway.
Neurologic sequelae of phosphide poisoning: A case report
Authors: Shafiee Dolat Abadi Sahel , Zamani Nasim , Abbasi Sahar , Shojaei Maziar , Hassanian-Moghaddam Hossein 
Published: September 2022

BackgroundAluminum phosphide (ALP) is extremely toxic with a high mortality rate, mainly due to its cardiovascular complications. Some neurologic effects have also been reported with this pesticide.Case presentationWe present a 23-year-old male who presented with confusion after ingestion of a toxic dose of ALP. Computerized tomography scan demonstrated diffuse bilateral hypoattenuation of the cerebellar hemispheres, midbrain, thalamus, and globus pallidus resulting in tonsillar and transtentorial herniation and eventually brain death four days after admission.ConclusionsThis is the first documented case of neurologic sequela following phosphide poisoning that emphasizes the importance of brain imaging studies for patients with loss of consciousness.
Automated measurement of endometrial peristalsis in cine transvaginal ultrasound images
Authors: Wang Yue , Li Xiaokun , Wei Niya , Liu Yuanxi , Liu Xinting , Sun Ruijie , Huang Chan , Yao Bin , Wang Huifang 
Published: September 2022

Objectives: Endometrial peristalsis (EP) in non-pregnant uterine can be assessed by visual assessment of transvaginal ultrasound (TVUS). However, visual assessment is subjective, and the outcome depends on the sonographers and video analysts. This study aimed to create a newly developed automatic analysis algorithm for measuring the EP compared to visual assessment.Methods: A retrospective analysis was performed using the datasets from in vitro fertilization and embryo transfer (IVF-ET), who underwent the evaluation of EP by TVUS within 5 days prior to transplantation. 158 cine TVUS images were used to develop the automated analysis algorithm, and 37 cine TVUS images were evaluated by both visual and automated analysis algorithms. The algorithm was developed by applying the optical flow technology and enabled objective analysis of the number, direction, and intensity of EP.Results: The number of peristaltic waves counted by visual assessment was 4.2 ± 2.3 (mean ± standard deviation) and 4.1 ± 2.1 for doctors one and two, respectively. The number of waves counted with the algorithm was 3.6 ± 2.1 at first evaluation and 3.7 ± 2.0 at repeated evaluation. A significant difference was found between the algorithm count and visual assessment (p = 0.001, 0.002, 0.003, 0.008). The ICC values for algorithm versus manuals ranged from 0.84 to 0.96 and 0.87 to 0.96. The numbers of the cervix-to-fundus (CF), fundus-to-cervix (FC), and both cervix-to-fundal and fundus-to-cervix (CF + FC) directions of EP counted by the algorithm were 50, 52, and 32, respectively. The numbers counted by visual assessment were 43, 45, and 46, respectively. The number of EP was the same in 87% of the two algorithm counts. The number was lower between the algorithm and visual analysis (79% with complete agreement). The EP intensity assessed by the algorithm was 2.6 ± 1.1, and the peristalsis velocity was 0.147 (0.07) mm/s.Conclusion: The fully automated analysis algorithm can be used to quantify uterine peristalsis comparable to visual assessment.
Experimental Investigation of Cohesion between UHPC and NSC Utilising Interface Protrusions
Authors: Horák Pavel , Pešková Šárka , Jogl Marcel , Sovják Radoslav , Vítek Petr 
Published: September 2022

The interaction of ultrahigh-performance concrete (UHPC) and normal-strength concrete (NSC) is one of the main issues for strengthening conventional concrete structures or other applications where NSC and UHPC are interrelated. UHPC stands out for its strength and durability, while NSC is significantly inexpensive and easier to work with. Efficiently designed structures can exploit the advantages of both mixtures. At the interface of these materials in newly designed structures, the formwork can be modified at the interface to give the concrete surface sufficient roughness and thus cohesion as required. This improves both the tensile and shear strength of the contact resulting in the enhanced capacity of the composite structure. In this study, a button foil was inserted into the formwork for the UHPC and then a part of NSC was made. The shear strength of the interface without any stress component in the transverse direction was measured on small-scale samples. It was to justify the possibility of the use of this interface in real constructions such as beams and columns. The main objective of further research is to design a composite beam using a UHPC shell as formwork for NSC and protrusions at the interface. It is expected that the U-shaped shell made of the UHPC could significantly contribute to the load-bearing capacity of the resulting composite NSC–UHPC structure and also to its enhanced durability. In addition, if the NSC is enclosed in a shell of UHPC, it can be made from various secondary materials, therefore it can decrease cement consumption by more than 50%.
tPCS as a method for correcting cardiac arrhythmias after percutaneous transluminal coronary angioplasty with stenting in patients with myocardial infarction
Authors: Kade A. Kh. , Sorokina E. A. , Raff S. A. , Trofimenko A. I. , Zanina E. S. , Muratova А. Yu. 
Published: September 2022

Objective: To study the effect of transcranial pulsed current stimulation (tPCS) therapy on cardiac arrhythmias developed after percutaneous transluminal coronary angioplasty (PTCA) with stenting in patients with myocardial infarction (MI).Material and methods: Characteristics of patient groups: the comparison group (n = 17) – with myocardial infarction, after PTCA with stenting, standard treatment; the main group (n = 21) – the same and tPCS therapy. Control points of the study: 1st day – Electrocardiography (ECG), Echocardiography (ECHO), Creatine phosphokinase (CPK), Creatine phosphokinase-MB (CPK-MB), Troponin-I, potassium, β-endorphin; 5th day – the same without ECHO; 10th day – the same and ECG with the determination of harmony and quantum of the electromagnetic flux of the cardiac cycle. PTCA was performed using drug-eluting stents. tPCS therapy was performed in pulsed bipolar mode, current strength 2 mA, current frequency 77.5 Hz, session duration 45 min.Results: In patients of the main group (against the background of tPCS therapy), the studied parameters of the cardiac cycle approached the optimal values. It was shown that intergroup differences in harmony (p = 0.002) and the size of the electromagnetic flux quantum of the cardiac cycle (p = 0.001) are statistically significant. Also, against the background of the tPCS therapy, the concentration of highly sensitive troponin-I is statistically significantly (p = 0.0042) lower by 109%. On the 5th and 10th days of the study, the serum concentration of β-endorphin in the main group was higher by 38.3 and 35.0% than in the comparison group (p < 0.05).Conclusion: The results of the study clearly demonstrate the cardioprotective and antiarrhythmic potential of tPCS therapy in patients with myocardial infarction and cardiac arrhythmias after PTCA with stenting.