bluuebunny/crossref_metadata_2025_split huggingface dataset:
“I would help the lecturer with marking”: Entrepreneurial Education Insights on Academic Resilience from the Perspectives of Engineering Students in South Africa
Authors: Mapaling Curwyn , Webb Paul , du Plooy Belinda 
Published: December 2022

AbstractsSeveral factors contribute to the alarmingly high youth unemployment rate in South Africa. Barriers such as lack of access to education and practical work experience reflect these statistics and the socio-economic implications of graduate unemployment. This qualitative case study investigated the perceptions of engineering students' academic resilience in the context of higher education by using a youth development approach. Semi-structured interviews were conducted online via Zoom with a sample consisting of 10 participants (aged 22–28 years), namely four Civil engineering students, four Electrical engineering students, and two Industrial engineering students. Six students were South African, whilst the remaining four were international students. Seven participants self-identified as male and three as female. Findings are discussed in terms of the three themes which emerged from the thematic analysis: (a) personal character strengths; (b) access to guidance, resources, and information and (c) a sense of belonging and social connection. This study focused on engineering education and developed a new interdisciplinary understanding of how entrepreneurship education may contribute to engineering students' academic resilience as a packaged support system that speaks to their psychosocial, educational and economic needs.
Developing Responsible and Sustainable Innovations in Entrepreneurship Education—Introducing the Sandbox Approach
Authors: Meyer Verena , Martins Flavio Pinheiro , Reihlen Markus , Pleß Fabian , Zadeh Yasmin Azim 
Published: December 2022

AbstractAs entrepreneurship educators, we typically bring together students in entrepreneurial teams and let them develop and work on their own ideas. Most of the time, their ideas are innovative, interesting, and inspiring. They also increasingly take sustainability into account, still this needs to be fostered systematically. So how could we support these students to tackle global challenges and develop sustainable ideas? To develop more sustainable ideas, entrepreneurship education concepts need to bridge the perspectives of multiple stakeholders. Developing innovation communities within a framework of an open innovation process presents a suitable approach with a possible long-term impact in this regard. The “Sandbox Innovation Process” combines a structured open innovation process while fostering an innovation community enabled to solve regional challenges. Using this workshop concept, participants can experience the “Sandbox Approach” at firsthand and develop comprehensive concepts for their common challenges. This workshop is a starting point to reflect on how researchers and educators in entrepreneurship can become key drivers for developing sustainable solutions. This is supported by a framework that takes contextual constraints into account and reflects on the Sustainable Development Goals.
The Finnish State and International Cultural Relations, 1945–1975
Authors: Clerc Louis 
Published: December 2022

AbstractCulture was no exception in Finland’s foreign policy during the Cold War: international cultural relations were one more stage on which the basic play of Finland’s Cold War domestic and foreign policies was performed. In the maze of justifications for improving the state’s capacity to coordinate and direct Finland’s spontaneous cultural relations used by its main Finnish administrators, historical memories, conceptions of desirable directions for Finland’s national development, the necessities of Finland’s geopolitical situation and more concrete notions linked to commercial and economic development appeared fundamentally important. The slow institutionalization of this cultural diplomacy and the activities it conducted aimed at Finland’s geopolitical stabilization and participation in international developments, and the country’s state-led cultural modernization.
Locally Refined B-Splines
Authors: Kermarrec Gaël , Skytt Vibeke , Dokken Tor 
Published: December 2022

AbstractThe univariate minimal support B-spline basis (UMB) has been used in Computer Aided Design (CAD) since the 1970s. Freeform curves use UMB, while sculptured surfaces are represented using a tensor product of two UMBs. The coefficients of a B-spline curve and surface are respectively represented in a vector and a rectangular grid. In CAD-intersection algorithms for UMB represented objects, a divide-and-conquer strategy is often used. Refinement by knot insertion is used to split the objects intersected into objects of the same type with a smaller geometric extent. In many cases the intersection of the resulting sub-objects has simpler topology than the original problem. The sub-objects created are represented using their parents’ UMB format and deleted when the sub-problem is solved. Consequently, no global representations of the locally refined bases are needed. This is contrary to when locally refined splines are used for approximation of large point sets. As soon as a B-spline is locally refined, the regular structure of UMB objects in CAD is no longer valid. In this chapter we discuss how Locally Refined B-splines (LR B-splines) address this challenge and present the properties of LR B-splines.
A Statistical Criterion to Judge the Goodness of Fit of LR B-Splines Surface Approximation
Authors: Kermarrec Gaël , Skytt Vibeke , Dokken Tor 
Published: December 2022

AbstractThe surface approximation obtained with adaptive strategies using locally refined (LR) B-splines depends on the degrees of freedom of the spline space, the tolerance from which the refinement is performed, the noise level of the scattered observations, the refinement strategy and the bidegree of the spline space. The choice of the best model is a challenging task that can be partially answered with statistical criteria, such as the Akaike Information Criterion (AIC). Here we relax the assumption that the approximation error should be normally distributed and with equal variance and propose the use of the student distribution to compute the AIC. We apply the AIC to decide which tolerance, refinement level, or polynomial bidegree are the most adequate for an optimal fitting. We highlight how the resulting AIC can be combined with more usual criteria to judge the goodness of fit of the surface approximation.
LR B-Splines for Representation of Terrain and Seabed: Data Fusion, Outliers, and Voids
Authors: Kermarrec Gaël , Skytt Vibeke , Dokken Tor 
Published: December 2022

AbstractPerforming surface approximation of geospatial point clouds with locally refined (LR) B-splines comes with several challenges: (i) Point clouds have varying data density, (ii) outliers should be eliminated without deleting features, (iii) voids, also called holes, or data gaps should be treated specifically to avoid the drop of the approximated surface in domains without points. These factors tend to be even more challenging when point clouds acquired from different sensors having different noise characteristics are fused together. The data set becomes non-uniform and the fusing process itself involves a risk of an increased noise level. In this chapter, we provide some tools to answer those specific challenges. We will use terrain and seabed data and show didactically how to perform adaptive surface approximation with local refinement and to select customized parameters. We will further address the problem of choosing an appropriate tolerance for performing an adaptive fitting, and discuss the refinement strategies within the context of LR B-splines. The latter is shown to provide a promising framework for surface fitting of heterogeneous point clouds from various sources.
Arthrofibrosis is a common but poorly defined complication in multiligament knee injuries: a systematic review
Authors: Fahlbusch Hendrik , Krivec Lukas , Müller Sebastian , Reiter Alonja , Frosch Karl Heinz , Krause Matthias 
Published: December 2022

Abstract
Purpose
The purpose of this study is to systematically review multiligament knee injury (MLKI) outcome studies to determine definitions of arthrofibrosis (AF) and provide information about incidence, management as well as potential risk factors.

Methods
A systematic literature search was performed (PubMed and Cochrane library) following the PRISMA guidelines of operatively treated MLKI (Schenck II–IV) studies reporting the incidence of AF. Twenty-five studies met the inclusion criteria. Injury pattern, timing of surgery, surgical technique, treatment of AF, rehabilitation programs and PROMS were inquired. Risk of bias and quality of evidence were assessed using the Coleman methodological score.

Results
Twenty-five studies with a total of 709 patients with a mean age of 33.6 ± 4.8 years were included and followed 47.2 ± 32.0 months. The majority of studies (22/25) used imprecise and subjective definitions of AF. A total of 86 patients were treated for AF, resulting in an overall prevalence of 12.1% (range 2.8–57.1). Higher-grade injuries (Schenck III–IV), acute treatment and ROM (range of motion) limiting rehabilitation programs were potential risk factors for AF. The time from index surgery to manipulation anesthesia (MUA) and arthroscopic lysis of adhesions (LOA) averaged at 14.3 ± 8.8 and 27.7 ± 12.8 weeks. Prior to MUA and LOA, the ROM was 51.7° ± 23.5 and 80.2° ± 17.0, resulting in a total ROM gain after intervention of 65.0° ± 19.7 and 48.0° ± 10.6, respectively; with no reports of any complication within the follow-up. The overall methodological quality of the studies was poor as measured by the Coleman score with average 56.3 ± 12.5 (range 31–84) points.

Conclusions
AF is a common but poorly defined complication particularly in high-grade MLKI. Early postoperative and intensified physiotherapy is important to reduce the risk of AF. MUA and LOA are very effective treatment options and result in good clinical outcome. Prospective studies with bigger study population are needed to optimize treatment algorithms of further patients after MLKI.
The protocol of this systematic review has been prospectively registered with PROSPERO (CRD42021229187, January 4th, 2021).
A Computational Study of Blood Flow Dynamics in the Pulmonary Arteries
Authors: Marcinno’ Fabio , Zingaro Alberto , Fumagalli Ivan , Dede’ Luca , Vergara Christian 
Published: December 2022

AbstractIn this work we study the blood dynamics in the pulmonary arteries by means of a 3D-0D geometric multiscale approach, where a detailed 3D model for the pulmonary arteries is coupled with a lumped parameters (0D) model of the cardiovascular system. We propose to investigate three strategies for the numerical solution of the 3D-0D coupled problem: the Splitting-Explicit and Implicit algorithms, where information are exchanged between 3D and 0D models at each time step at the interfaces, and the One-Way algorithm, where the 0D is solved first off-line. In our numerical experiments performed in a realistic patient-specific 3D domain with a physiologically calibrated 0D model, we discuss first the issue on instabilities that may arise when not suitable connections are considered between 3D and 0D models; second we compare the performance and accuracy of the three proposed numerical strategies. Finally, we report a comparison between a healthy and a hypertensive case, providing a preliminary result highlighting how our method could be used in future for clinical purposes.
Emerging inequality in Kenyan secondary schools: Dilemmas of educational expansion and quality improvement
Authors: Ogawa Miku 
Published: December 2022

AbstractThis article examines the emerging unfair inequality in Kenyan secondary schools through comparative case studies of three secondary schools in western Kenya. Qualitative data were collected through fieldwork over a four-year period, with participant observation and semi- or non-structured interviews, to understand how interactions among schools, households, and communities impact the improvement of educational quality. This study demonstrates that educational inequality stems from economic background and academic performance. While establishing new schools allowed students to choose better schools in their vicinity, increasing school competition resulted in a school hierarchy restricting uniform access due to factors of affordability and academic achievement. This suggests that the unplanned establishment of new schools constrains vulnerable students from continuing their education. Expanding educational opportunities and improving quality are important facets of education; however, it is necessary to pay attention to the beneficiaries of this process, as economic inequality may translate into educational inequality.
Vision-related quality of life compared to generic measures in retinoblastoma survivors
Authors: Belson Paula J. , Pike Nancy A. , Eastwood Jo-Ann , Brecht Mary-Lynn , Berry Jesse L. , Hays Ron D. 
Published: December 2022

Abstract
Purpose
To (1) Compare vision-related quality of life (VRQOL) in adolescent and young adult (AYA) unilateral versus bilateral retinoblastoma (RB) survivors using a vision-targeted measure and a generic health-related quality of life (HRQOL) measure and (2) Assess associations among VRQOL and generic HRQOL domains and overall QOL and estimate associations of the VRQOL and HRQOL domains with overall QOL.

Methods
The National Institute for Health (NIH) Toolbox® VRQOL instrument, PROMIS®-29 Profile v 2.1, and a single-item QOL measure were administered in a cross-sectional study of 101 RB survivors. Reliability for multi-item scales was estimated. Product-moment and Spearman rank correlation coefficients and stepwise ordinary least squares were used to measure associations of other variables with overall QOL.

Results
Significantly worse VRQOL was reported by bilateral than unilateral RB survivors. Cronbach’s alpha coefficients for all VRQOL scales ranged from 0.83 to 0.95. Medium to large correlations were found between all NIH Toolbox® VRQOL scales and the PROMIS®-29 measures. Depression and ability to participate in social roles and activities from the PROMIS®-29 Profile accounted for 38% of the variance in overall QOL with the psychosocial domain of the NIH Toolbox® VRQOL explaining 16% of the variance.

Conclusion
VRQOL is impaired in bilateral RB survivors. VRQOL is associated substantially with the PROMIS-29 generic HRQOL measure but has significant unique associations with overall QOL. The NIH Toolbox® VRQOL measure provides important information about the vision-related effects on daily life of AYA RB survivors.
Recovery of platinum group metals from spent automotive converters and their conversion into efficient recyclable nanocatalysts
Authors: Wiecka Zuzanna , Cota Iuliana , Tylkowski Bartosz , Regel-Rosocka Magdalena 
Published: December 2022

AbstractThe study reported in this article has shown for the first time that strongly acidic solutions (pH < 0.5) obtained after hydrometallurgical treatment of spent automotive converters (SAC) may be valuable secondary sources of platinum group metal (PGM) nanoparticles (NPs). The PGM precipitation strongly depended on the solution pH; the yield of the precipitated PGM NPs increased considerably from 40% to almost 100% when the pH was adjusted to 7–8. To improve the NPs stability, commercial TiO2was used as support to obtain efficient recyclable PGM@TiO2catalysts. The size of the PGM NPs was smaller than 5 nm, while the diameter of the supported particles varied from 10 to 50 nm. The size and dispersion of PGM NPs on the support strongly depended on the pH of the medium: at pH < 0.5, the Pt and Pd NPs were significantly smaller than the NPs obtained at pH 7–8. Also, in the case of Pt@TiO2and Rh@TiO2, the NPs were well dispersed on the support in contrast to the large agglomerates of Pd@TiO2. The PGM@TiO2showed catalytic properties in the reduction of 4-nitrophenol to 4-aminophenol, particularly, at pH above 11. The highest conversion of 98% was obtained with 1% Pd@TiO2at pH 14 after only 15 min. The catalyst was easily separated from the reaction mixture and reused in 7 consecutive cycles without significant loss of activity. The PGM@TiO2synthesized from the real solution showed a similar catalytic activity (70% conversion at pH 14) as that obtained from model solution.
Cross-Border Dynamics of IP Modularity: International Patenting in LEDs and Lithium-Ion Secondary Battery Technology
Authors: Bican Peter M. , Caspary Dirk , Guderian Carsten C. 
Published: December 2022

AbstractTo profit from their inventions, multinational enterprises rely on various appropriation and internationalization strategies. Intellectual property modularity serves as a reliable option to master the tradeoff between owning the “right” (i.e., valuable) patents in a technology and sharing other “less valuable” patents to spur innovation and foster technology dissemination. Through an inductive, multi-case approach looking at light-emitting diodes and lithium-ion secondary battery technology, we expand prior intellectual property modularity to incorporate internationalization effects across borders. Relying on patent classifications, we trace the development of these two technologies and key multinational enterprises in various countries longitudinally from 1990 to 2018. We introduce the Dynamic IP Modularity Application Matrix and demonstrate that integrating the firm and country levels yields insights into dynamic internationalization developments, particularly when considering the drawbacks to intellectual property modularity. Herein, decision-makers need to secure not only currently valuable but also potentially valuable intellectual property to successfully apply an international intellectual property modularity value capture strategy.
Maternal Undernutrition Induces Cell Signalling and Metabolic Dysfunction in Undifferentiated Mouse Embryonic Stem Cells
Authors: Khurana Pooja , Cox Andrew , Islam Barira , Eckert Judith J. , Willaime-Morawek Sandrine , Gould Joanna M. , Smyth Neil R. , McHugh Patrick C. , Fleming Tom P. 
Published: December 2022

Abstract
Peri-conceptional environment can induce permanent changes in embryo phenotype which alter development and associate with later disease susceptibility. Thus, mouse maternal low protein diet (LPD) fed exclusively during preimplantation is sufficient to lead to cardiovascular, metabolic and neurological dysfunction in adult offspring. Embryonic stem cell (ESC) lines were generated from LPD and control NPD C57BL/6 blastocysts and characterised by transcriptomics, metabolomics, bioinformatics and molecular/cellular studies to assess early potential mechanisms in dietary environmental programming. Previously, we showed these lines retain cellular and epigenetic characteristics of LPD and NPD embryos after several passages. Here, three main changes were identified in LPD ESC lines. First, their derivation capacity was reduced but pluripotency marker expression was similar to controls. Second, LPD lines had impaired Mitogen-activated protein kinase (MAPK) pathway with altered gene expression of several regulators (e.g., Maff, Rassf1, JunD), reduced ERK1/2 signalling capacity and poorer cell survival characteristics which may contribute to reduced derivation. Third, LPD lines had impaired glucose metabolism comprising reduced upstream enzyme expression (e.g., Gpi, Mpi) and accumulation of metabolites (e.g., glucose-6-P, fructose-6-P) above the phosphofructokinase (PFK) gateway with PFK enzyme activity reduced. ESC lines may therefore permit investigation of peri-conceptional programming mechanisms with reduced need for animal experimentation.
Graphical Abstract
Zinc finger myeloid Nervy DEAF-1 type (ZMYND) domain containing proteins exert molecular interactions to implicate in carcinogenesis
Authors: Wu Longji , Huang Jing , Trivedi Pankaj , Sun Xuerong , Yu Hongbing , He Zhiwei , Zhang Xiangning 
Published: December 2022

AbstractMorphogenesis and organogenesis in the low organisms have been found to be modulated by a number of proteins, and one of such factor, deformed epidermal auto-regulatory factor-1 (DEAF-1) has been initially identified in Drosophila. The mammalian homologue of DEAF-1 and structurally related proteins have been identified, and they formed a family with over 20 members. The factors regulate gene expression through association with co-repressors, recognition of genomic marker, to exert histone modification by catalyze addition of some chemical groups to certain amino acid residues on histone and non-histone proteins, and degradation host proteins, so as to regulate cell cycle progression and execution of cell death. The formation of fused genes during chromosomal translocation, exemplified with myeloid transforming gene on chromosome 8 (MTG8)/eight-to-twenty one translocation (ETO) /ZMYND2, MTG receptor 1 (MTGR1)/ZMYND3, MTG on chromosome 16/MTGR2/ZMYND4 and BS69/ZMYND11 contributes to malignant transformation. Other anomaly like copy number variation (CNV) of BS69/ZMYND11 and promoter hyper methylation of BLU/ZMYND10 has been noted in malignancies. It has been reported that when fusing with Runt-related transcription factor 1 (RUNX1), the binding of MTG8/ZMYND2 with co-repressors is disturbed, and silencing of BLU/ZMYND10 abrogates its ability to inhibition of cell cycle and promotion of apoptotic death. Further characterization of the implication of ZMYND proteins in carcinogenesis would enhance understanding of the mechanisms of occurrence and early diagnosis of tumors, and effective antitumor efficacy.
A case of chronic disseminated candidiasis in metamizole-induced neutropaenia
Authors: Colin-Benoit Eugénie , Kalubi Malela , Zimmerli Stefan 
Published: December 2022

AbstractChronic disseminated candidiasis (CDC) is a severe complication of a disseminated yeast infection mainly seen after prolonged chemotherapy-induced neutropaenia in the context of haematological malignancy. We present a case of CDC in a patient with metamizole-induced neutropaenia. To the best of our knowledge, this is the first case described in this context. Furthermore, we highlight the role of steroids in the management of this disease.
A Multidimensional Information Management Framework for Strategic Digital Cities: A Comparative Analysis of Canada and Brazil
Authors: Teixeira Alex V. , Rezende Denis Alcides 
Published: December 2022

Abstract
Management and information systems are essential for strategic cities since they provide customized digital services that connect specific information and its context to form a multidimensional construct. The objective of this study is to perform an information analysis in two cities to develop a strategic multidimensional framework. The research methodology was based on the model theory. It took into consideration the digital services from two cities supported by non-participatory observations and a bibliographic review. The data were collected hierarchically and compared with five related international frameworks using the infomapping technique. The framework comprised three constructs and ten multidimensional variables that related the conceptual theories to the developed and applied model. The research was conducted in Rio de Janeiro, Brazil, and Regina, Saskatchewan, Canada. The results indicated disconnections between one or more of the variables surveyed, limited customized services, and recurrent use of information in a bidirectional form. The conclusions emphasized the multidimensional character of information in terms of its dynamic nature and relations with distinct levels of information management. In addition, the study established a framework for strategic digital cities based on new interactive relations between public information management and digital services, including the city’s strategic policies. In terms of its contribution to the literature, this research highlighted the dynamic nature of information and strategic digital cities.