bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influencing factors of care dependence in patients with coronary heart disease after percutaneous coronary intervention—A cross‐sectional study
Authors: Guo Juan , Chen Youyou , Dai Yu , Chen Qin , Wang Xiyong 
Published: August 2022

AbstractAimCare dependence has been scarcely investigated in coronary heart disease patients after percutaneous coronary intervention. This study aimed to investigate the association between frailty, self‐efficacy, combined effects of frailty and self‐efficacy, mental health, and care dependence in coronary heart disease patients after percutaneous coronary intervention.DesignCross‐sectional study.MethodsData from 400 patients after percutaneous coronary intervention were collected from 2017–2020. Logistic regression model and mediating analysis were used to identify the association between frailty, self‐efficacy, combined effects of frailty and self‐efficacy, and care dependence.ResultsPatients with frailty and self‐efficacy tended to have severe care dependence symptoms. There was no correlation between frailty symptoms, self‐efficacy, and care dependence in patients without symptoms of anxiety or depression. But in patients with anxiety or depression symptoms, there is a strong correlation between frailty symptoms, lower self‐efficacy, and care dependence. Mental health played an inhibitory effect on frailty and care dependence.
A cross‐sectional observational study on the level of diabetes knowledge and related influencing factors among orthopaedic nurses
Authors: Shi Wenli , Yao Huilan , Guo Zihe , Fan Shunwu , Pan Hongying , Liu Chao 
Published: August 2022

AbstractAimTo evaluate the level of diabetes knowledge and related influencing factors among Chinese orthopaedic nurses.DesignA cross‐sectional observational study. The STROBE checklist was followed.MethodsA convenience sampling method was adopted by using the Questionnaire Star application to publish online questionnaire. The nurses' diabetes knowledge levels were assessed, including a total of 34 items from the “Orthopaedic Nurses Diabetes Knowledge Mastery Questionnaire” and the “Orthopaedic Nurses General Information Questionnaire” between July 2020 and September 2020.ResultsAltogether, 363 nurses participated in the survey. Their levels of diabetes‐related knowledge were moderate or lower (16.51 ± 2.96 out of 25 points). The knowledge level was closely related to five factors: professional title, education level, whether the hospital employed diabetes specialist nurses or treated outpatients, type of diabetes‐related training received and whether the individual was familiar with and adhered to current treatment guidelines. The knowledge level can be improved by providing additional training that accounts for these factors.
Value‐Based Payments in Health Care: Evidence from a Nationwide Randomized Experiment in the Home Health Sector
Authors: Li Jun 
Published: August 2022

AbstractValue‐based payment programs, also known as pay‐for‐performance, use financial incentives to motivate providers to invest in quality and are a critical part of Medicare health care reform. This study examines the first year of the Home Health Value‐Based Purchasing program, a nationally representative cluster randomized experiment implemented by the Centers for Medicare & Medicaid Services in 2016. The goal of the program is to achieve better home health care quality. Home health agencies in treatment states were rewarded or penalized based on their performance on agency‐reported and non‐agency‐reported quality measures. The program improved agency‐reported measures by approximately one percentage point, and performance gains suggest a dose‐response relationship with respect to incentive size. However, the performance gains in agency‐reported measures did not reflect true quality improvement. I find evidence that agencies manipulated their coding of patients and inflated their performance. Coding manipulation explains the entirety of the program's impact on agency‐reported measures.
Age‐ and sex‐specific rates of gall bladder disease in children with sickle cell disease
Authors: Agawu Atu , Shults Justine , Smith‐Whitley Kim , Feudtner Chris 
Published: August 2022

AbstractBackgroundChildren with sickle cell disease (SCD) have an increased risk for gallstones due to chronic hyperbilirubinemia from hemolysis. Although gallstones are a known complication, there is variability in estimates of disease burden and uncertainty in the association between sex and gall bladder disease (GBD).MethodsThis was a retrospective cohort study of children with SCD using administrative claims data (January 1, 2014–December 31, 2018). Population‐averaged multivariable panel‐data logistic regression models were used to evaluate the association between GBD clinical encounters (outcome) and two exposures (age and sex). Annual GBD risk was calculated using predictive margins, adjusting for disease severity, transfusion frequency, and hydroxyurea exposure.ResultsA total of 13,745 individuals (of 21,487 possible) met inclusion criteria. The population was evenly split across sex (49.5% female) with predominantly Medicaid insurance (69%). A total of 946 individuals (6.9%) had GBD, 432 (3.1%) had a gallstone complication, and 487 (3.5%) underwent cholecystectomy. The annual risk of GBD rose nonlinearly from 1 to 5% between ages 1 and 19 years with no difference between males and females. Cholecystectomy occurred primarily in individuals with GBD (87%), and neither age nor sex was associated with cholecystectomy in this population. High disease severity (compared with low) more than doubled the annual risk of GBD at all ages.ConclusionsGBD is associated with age but not sex in children with SCD. Neither age nor sex is associated with risk of cholecystectomy. High disease severity increases the rate of GBD at all ages.
Joint longitudinal trajectories of pain intensity and opioid prescription in veterans with back pain
Authors: Buta Eugenia , Gordon Kirsha S. , Gueorguieva Ralitza , Becker William C. , Heapy Alicia , Bathulapalli Harini , Zeng Qing , Redd Doug , Brandt Cynthia , Goulet Joseph 
Published: August 2022

AbstractPurposeWe describe pain intensity and opioid prescription jointly over time in Veterans with back pain to better understand their relationship.MethodsWe performed a retrospective cohort study on electronic health record data from 117 126 Veterans (mean age 49.2 years) diagnosed with back pain in 2015. We used latent class growth analysis to jointly model pain intensity (0–10 scores) and opioid prescriptions over 2 years to identify classes of individuals similar in their trajectory of pain and opioid over time. Multivariable multinomial logit models assessed sociodemographic and clinical predictors of class membership.ResultsWe identified six trajectory classes: a “no pain/no opioid” class (22.2%), a “mild pain/no opioid” class (45.0%), a “moderate pain/no opioid” class (24.6%), a “moderate, decreasing pain/decreasing opioid” class (3.3%), a “moderate pain/high opioid” class (2.6%), and a “moderate, increasing pain/increasing opioid” class (2.3%). Among those in moderate pain classes, being white (vs. non‐white) and older were associated with higher odds of being prescribed opioids. Veterans with mental health diagnoses had increased odds of being in the painful classes versus “no pain/no opioid” class.ConclusionWe found distinct patterns in the long‐term joint course of pain and opioid prescription in Veterans with back pain. Understanding these patterns and associated predictors may help with development of targeted interventions for patients with back pain.
Lung recruitment in neonatal high‐frequency oscillatory ventilation with volume‐guarantee
Authors: Solis‐Garcia Gonzalo , González‐Pacheco Noelia , Ramos‐Navarro Cristina , Vigil‐Vázquez Sara , Gutiérrez‐Vélez Ana , Merino‐Hernández Amaia , Rodríguez Sánchez De la Blanca Ana , Sánchez‐Luna Manuel 
Published: August 2022

AbstractBackground and ObjectivesThe optimal lung volume strategy during high‐frequency oscillatory ventilation (HFOV) is reached by performing recruitment maneuvers, usually guided by the response in oxygenation. In animal models, secondary spontaneous change in oscillation pressure amplitude (ΔPhf) associated with a progressive increase in mean airway pressure during HFOV combined with volume guarantee (HFOV‐VG) identifies optimal lung recruitment. The aim of this study was to describe recruitment maneuvers in HFOV‐VG and analyze whether changes in ΔPhf might be an early predictor for lung recruitment in newborn infants with severe respiratory failure.Design and MethodsThe prospective observational study was done in a tertiary‐level neonatology department. Changes in ΔPhf were analyzed during standardized lung recruitment after initiating early rescue HFOV‐VG in preterm infants with severe respiratory failure.ResultsTwenty‐seven patients were included, with a median gestational age of 24 weeks (interquartile range [IQR]: 23–25). Recruitment maneuvers were performed, median baseline mean airway pressure (mPaw) was 11 cm H2O (IQR: 10–13), median critical lung opening mPaw during recruitment was 14 cm H2O (IRQ: 12–16), and median optimal mPaw was 12 cm H2O (IQR: 10–14, p < 0.01). Recruitment maneuvers were associated with an improvement in oxygenation (FiO2: 65.0 vs. 45.0, p < 0.01, SpO2/FiO2 ratio: 117 vs. 217, p < 0.01). ΔPhf decreased significantly after lung recruitment (mean amplitude: 23.0 vs. 16.0, p < 0.01).ConclusionIn preterm infants with severe respiratory failure, the lung recruitment process can be effectively guided by ΔPhf on HFOV‐VG.
A model selection criterion for clustered survival analysis with informative cluster size
Authors: Chien Li‐Chu , Chang Li‐Ying , Shen Chung‐Wei 
Published: August 2022

AbstractWe propose a model selection criterion for correlated survival data when the cluster size is informative to the outcome. This approach, called Resampling Cluster Survival Information Criterion (RCSIC), uses the Cox proportional hazards model that is weighted with the inverse of the cluster size. The RCSIC based on the within‐cluster resampling idea takes into account the possible variability of the within‐cluster subsampling and the possible informativeness of cluster sizes. The RCSIC allows for easy execution for the within‐cluster resampling idea without a large number of resamples of the data. In contrast with the traditional model selection method in survival analysis, the RCSIC has an additional penalization for the within‐cluster subsampling variability. Our simulations show the satisfactory results where the RCSIC provides a more robust power for variable selection in terms of clustered survival analysis, regardless of whether informative cluster size exists or not. Applying the RCSIC method to a periodontal disease studies, we identify the tooth loss in patients associated with the risk factors, Age, Filled Tooth, Molar, Crown, Decayed Tooth, and Smoking Status, respectively.
Nigakinone alleviates DSS‐induced experimental colitis via regulating bile acid profile and FXR/NLRP3 signaling pathways
Authors: Liu Fangle , Yao Yufeng , Wang Qian , Zhang Fengxue , Wang Meiqi , Zhu Chenchen , Lin Chaozhan 
Published: August 2022

AbstractThe correlation of bile acid (BA) metabolism disorder with the pathogenesis of ulcerative colitis (UC) is realized nowadays. Farnesoid X receptor (FXR), a controller for BA homeostasis and inflammation, is a promising target for UC therapy. Nigakinone has potential therapeutic effects on colitis. Herein, we investigated the anti‐UC effects and mechanism of nigakinone in colitic animals induced by dextran sulfate sodium (DSS). The related targets involved in the nucleotide‐binding oligomerization domain, leucine‐rich repeat, and pyrin domain‐containing 3 (NLRP3) signaling pathway were measured. BA‐targeted metabolomics was employed to reveal the regulatory effects of nigakinone on BA profile in colitis, while expressions of FXR and its mediated targets referring to BA enterohepatic circulation were determined. The critical role of FXR in the treatment of nigakinone for colitis was studied via molecule‐docking, dual‐luciferase reporter® (DLR™) assays, FXR silencing cells, and FXR knockout mice. Results showed nigakinone attenuated DSS‐induced colitis symptoms, including excessive inflammatory response by NLRP3 activation, and injury of the intestinal mucosal barrier. Nigakinone regulated BA disorders by controlling cholesterol hydroxylase and transporters mediated by FXR, then decreased BA accumulation in colon. Molecular‐docking and DLR™ assays indicated FXR might be a target of nigakinone. In vitro, nigakinone restrained BA‐induced inflammation and cell damage via FXR activation and inhibition of inflammatory cytokines. However, ameliorating effects of nigakinone on colitis were suppressed by FXR knockout or silencing in vivo or in vitro. Taken together, nigakinone ameliorated experimental colitis via regulating BA profile and FXR/NLRP3 signaling pathway.
Fate & transport of vinyl chloride in soil vapor
Authors: Eklund Bart , Rago Rich , Plantz Gina , Haddad Elie , Miesfeldt Mark , Volpi Rick 
Published: August 2022

AbstractVinyl chloride (VC) is a common risk driver in vapor intrusion (VI) studies. At many sites, initial screening shows potential indoor air impacts for VC at unacceptable levels. During follow‐up site characterization, however, the VI pathway for VC is rarely if ever found to be complete. This paper sets forth a conceptual model for understanding these results and summarizes data from several field sites to illustrate the concepts. VC can be formed under anaerobic conditions via reductive dechlorination of tetrachloroethylene or trichloroethylene. The ultimate fate of any VC that is produced depends on the amount of available oxygen. If sufficient oxygen is available, VC will readily undergo aerobic biodegradation. Data are presented for multiple field sites to illustrate the fate and transport of VC. The sites are drawn from various regions of the United States and cover a range of conditions. At these sites, VC was detected at relatively high concentrations in groundwater. It may also have been detected in deeper soil gas, but generally was fully attenuated before reaching shallow soil depths. Indoor air results were consistently non‐detect. The behavior is also discussed for sites with very shallow groundwater, where VC was found in some subslab soil gas samples but not in the overlying indoor air.
Formulating Zwitterionic, Responsive Polymers for Designing Smart Soils
Authors: Zhang Dong , Tang Yijing , Zhang Chang , Huhe FNU , Wu Baoyi , Gong Xiong , Chuang Steven S. C. , Zheng Jie 
Published: August 2022

AbstractThe design of new remediation strategies and materials for treating saline–alkaline soils is of fundamental and practical importantance for many applications. Conventional soil remediation strategies mainly focus on the development of fertilizers or additives for water, nutrient, and heavy metal managements in soils, but they often overlook a soil sensing function for early detection of salinization/alkalization levels toward optimal and timely soil remediation. Here, new smart soils, structurally consisting of the upper signal soil and the bottom hygroscopic bed and chemically including zwitterionic, thermo‐responsive poly(NIPAM‐co‐VPES) and poly(NIPAM‐co‐SBAA) aerogels in each soil layer are formulated. Upon salinization, the resultant smart soils exhibit multiple superior capacities for reducing the soil salinity and alkalinity through ion exchange, controlling the water cycling, modulating the degradation of pyridine‐base ligands into water‐soluble, nitrogenous salts‐rich ingredients for soil fertility, and real‐time monitoring salinized soils via pH‐induced allochroic color changes. Further studies of plant growth in smart soils with or without salinization treatments confirm a synergy effect of soil remediation and soil sensing on facilitating the growth of plants and increasing the saline–alkaline tolerance of plants. The esign concept of smart soils can be further expanded for soil remediation and assessment.
Biomimetic Assembly of Spore@ZIF‐8 Microspheres for Vaccination
Authors: Peng Fei , Xiang Yuqiang , Wang Hui , Hu Yanjie , Zhou Rui , Hu Yonggang 
Published: August 2022

AbstractVaccines have been one of the most powerful weapons to defend against infectious diseases for a long time now. Subunit vaccines are of increasing importance because of their safety and effectiveness. In this work, a Bacillus amyloliquefaciens spore@zeolitic imidazolate framework‐8 (ZIF‐8) vaccine platform is constructed. The ovalbumin (OVA) is encapsulated in the ZIF‐8 shells as a model antigen to form a spore@OVA@ZIF‐8 (SOZ) composite. The assembly of ZIF‐8 improves the loading content of OVA on the spores and provides OVA with long‐term protection. The SOZ composite enhances the immunization efficacy in multiple ways, such as facilitation of antigen uptake and lysosome escape, stimulation of dendritic cells to mature and secrete cytokines, boosting of antibody production and formation of an antigen depot. This platform shows several advantages including easy preparation, cost‐effectiveness, long life, convenience of transportation and storage, and no need for the cold chain. These findings may have promising implications for the rational design of safe and effective spore‐based composite vaccine platforms.
Tumor Microenvironment‐Responsive Cu/CaCO3‐Based Nanoregulator for Mitochondrial Homeostasis Disruption‐Enhanced Chemodynamic/Sonodynamic Therapy
Authors: Zhao Yajie , Bian Yulong , Xiao Xiao , Liu Bin , Ding Binbin , Cheng Ziyong , Ma Ping'an , Lin Jun 
Published: August 2022

AbstractThe efficiency of reactive oxygen species (ROS)‐mediated cancer therapy is restrained by intrinsic characteristics in the tumor microenvironment (TME), such as overexpressed glutathione (GSH), hypoxia and limited efficiency of H2O2. In this work, intelligent copper‐dropped calcium carbonate loading sonosensitizer Ce6 nanoparticles (Cu/CaCO3@Ce6, CCC NPs) are established to realize TME‐responsive self‐supply of oxygen and successively Ca2+‐overloading‐strengthened chemodynamic therapy/sonodynamic therapy (CDT/SDT). CCC NPs release Ca2+, Cu2+, and Ce6 in weakly acid and GSH‐excessive TME. Released Cu2+ can not only consume GSH and turn into Cu+ via a redox reaction, but also provide CDT‐creating hydroxyl radicals through the Fenton‐like reaction. Under ultrasound irradiation, the intracellular oxidative stress is amplified profoundly relying on singlet oxygen outburst from SDT. Moreover, Ca2+ influx aggravates the mitochondrial disruption, which further accelerates the oxidation level. The facile and feasible design of the Cu‐dropped CaCO3‐based nanoregulators will be further developed as a paradigm in ROS‐contributed cancer therapy.
Pt–Co Electrocatalysts: Syntheses, Morphologies, and Applications
Authors: Chen Hao , Liu Jianwen , Wu Xuexian , Ye Chunyi , Zhang Jiujun , Luo Jing‐Li , Fu Xian‐Zhu 
Published: August 2022

AbstractPt–Co electrocatalysts have attracted significant attention because of their excellent performance in many electrochemical reactions. This review focuses on Pt–Co electrocatalysts designed and prepared for electrocatalytic applications. First, the various synthetic methods and synthesis mechanisms are systematically summarized; typical examples and core synthesis parameters are discussed for regulating the morphology and structure. Then, starting with the design and structure–activity relationship of catalysts, the research progress of the morphologies and structures of Pt–Co electrocatalysts obtained based on various strategies, the structure–activity relationship between them, and their properties are summarized. In addition, the important electrocatalytic applications and mechanisms of Pt–Co catalysts, including electrocatalytic oxidation/reduction and bifunctional catalytic reactions, are described and summarized, and their high catalytic activities are discussed on the basis of their mechanism and active sites. Moreover, the advanced electrochemical in situ characterization techniques are summarized, and the challenges and direction concerning the development of high‐performance Pt–Co catalysts in electrocatalysis are discussed.
Quality by design assisted high‐performance liquid chromatography parameters for simultaneous estimation of simvastatin and fenofibrate
Authors: Rajput Geeta , Patel Preeti , Singh Dilpreet , Asati Vivek , Kurmi Balak Das 
Published: August 2022

AbstractIn a present study quality by design was used to develop a reliable high‐performance liquid chromatography method for simultaneous estimation of simvastatin and fenofibrate. A robust chromatographic setting for quality peaks and appropriate component separation within a reasonable run duration was generated. Furthermore, to determine critical quality attributes (CQA), a quantitative relationship between critical material attributes and CQA was established using Box‐Behnken design to produce analytical design space and develop a control approach. The mathematical models used three independent characteristics, acetonitrile volume, buffer molarity, and flow rate. The optimum and expected conditions were acetonitrile and potassium dihydrogen orthophosphate buffer (pH 2.9 adjusted, with orthophosphoric acid) (80.65:19.35 v/v) as an optimized mobile phase at a flow rate of 0.99 ml/min. We achieved adequate baseline separation of both drugs in just 10 min with these optimum parameters. The amount of acetonitrile was revealed to be the most important factor determining the perturbation plot responses. The %recoveries for both medicines were 99.15%–101.86% at all three levels. Both drugs showed relative standard deviations for repeatability, and intermediate precision were less than 2%. As a result, a simple, accurate, and repeatable high‐performance liquid chromatography approach for routine quality control testing was developed.
hUC‐MSCs exosomal miR‐451 alleviated acute lung injury by modulating macrophage M2 polarization via regulating MIF‐PI3K‐AKT signaling pathway
Authors: Liu Jisong , Xing Fuxi , Fu Quanyou , He Bo , Jia Zhigang , Du Juan , Li Yong , Zhang Xiangzhou , Chen Xulin 
Published: August 2022

AbstractIn the previous study, we have proved that exosomal miR‐451 from human umbilical cord mesenchymal stem cells (hUC‐MSCs) attenuated burn‐induced acute lung injury (ALI). However, the mechanism of exosomal miR‐451 in ALI remains unclear. Therefore, this study aimed to study the molecular mechanism of hUC‐MSCs‐derived exosomal miR‐451 on ALI by regulating macrophage polarization. Exosomes were isolated and identified by transmission electron microscope (TEM) and nanoparticle tracking analysis (NTA). The expression of miR‐451, macrophage migration inhibitory factor (MIF) and PI3K/AKT signaling pathway proteins were detected by qRT‐PCR and western blot. Flow cytometry was used to detect the CD80 and CD206 positive cells. Severe burn rat model was established and HE was used to detect the inflammatory cell infiltration and inflammatory injury. Dual luciferase reporter system was used to detect the regulation of miR‐451 to MIF. The contents of cytokines were detected by ELISA. The results showed that hUC‐MSCs exosomes promoted macrophage M1 to M2 polarization. Furthermore, hUC‐MSCs‐derived exosomal miR‐451 alleviated ALI development and promoted macrophage M1 to M2 polarization. Moreover, MIF was a direct target of miR‐451. Downregulation of MIF regulated by miR‐451 alleviated ALI development promoted macrophage M1 to M2 polarization. In addition, we found that MIF and hUC‐MSCs‐derived exosomal miR‐451 participated in ALI by regulating PI3K/AKT signaling pathway. In conclusion, we indicated that hUC‐MSCs‐derived exosomal miR‐451 alleviated ALI by modulating macrophage M2 polarization via regulating MIF‐PI3K‐AKT signaling pathway, which provided great scientific significance and clinical application value for the treatment of burn‐induced ALI.