bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of acetaminophen on preemptive multimodal analgesia in total knee arthroplasty: a prospective, double-blind, randomized placebo-controlled trial
Authors: Wang Qiuru , Wang Zhuoer , Ma Ting , Wang Liying , Zhao Chengcheng , Kang Pengde 
Published: August 2022

Abstract
BackgroundPreemptive multimodal analgesia is a commonly used method to control pain following total knee arthroplasty (TKA). This study aimed to evaluate the efficacy of preemptive acetaminophen for pain management in patients who underwent TKA.MethodsIn this prospective, double-blind, randomized placebo-controlled trial, 80 patients were randomized to the acetaminophen or control group. Patients in the acetaminophen group received celecoxib 400mg, pregabalin 150mg, and acetaminophen 325mg 2 hours before TKA. Patients in the control group received celecoxib, pregabalin, and placebo. Primary outcome was postoperative consumption of morphine hydrochloride used for rescue analgesia. Secondary outcomes included the time to the first rescue analgesia, postoperative pain as assessed by visual analogue scale (VAS), functional recovery as assessed by range of knee motion and ambulation distance, the time to hospital discharge, and complication rates.ResultsThere was no significant difference between the control group and the acetaminophen group in postoperative 0–24 h morphine consumption (average 11.3 mg vs. 12.3 mg, p = 0.445) and total morphine consumption (average 17.3 mg vs. 19.3 mg, p = 0.242). There was no significant difference in the time to the first rescue analgesia, postoperative VAS pain scores at any time points, postoperative functional recovery of knee, and the time to hospital discharge. The two groups had a similar occurrence of postoperative complications.ConclusionsThe addition of acetaminophen to preoperative preemptive multimodal analgesia could not reduce postoperative morphine consumption or improve pain relief. Orthopedic surgeons should reconsider routine use of preemptive acetaminophen in TKA.Trial registration: The study was prospectively registered on Chinese Clinical Trial Registry (identification number: ChiCTR2100052732) on 04/11/2021. http://www.chictr.org.cn/edit.aspx?pid=136730&htm=4
Impaired STING activation due to a variant in the E3 ubiqitin ligase AMFR in a patient with severe VZV infection and hemophagocytic lymphohistiocytosis
Authors: Thomsen Michelle , Heinz Johanna , Hollensen Anne , Carter-Timofte Madalina , Fisker Niels , Zhang Baocun , Paludan Søren , Assing Kristian , Mogensen Trine 
Published: August 2022

Abstract
Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus exclusively infecting humans, where it causes two distinct pathologies: varicella (chickenpox) upon primary infection and herpes zoster (shingles) following reactivation. In susceptible individuals, VZV can give rise to more severe clinical manifestations, including disseminated infection, pneumonitis, encephalitis, and vasculopathy. Here we describe a 3-year-old boy with severe VZV infection involving the central nervous system, subsequently triggering longstanding hemophagocytic lymphohistiocytosis (HLH). We found that the patient carries a rare monoallelic variant in autocrine motility factor receptor AMFR encoding an ubiquitin ligase involved in innate cytosolic DNA sensing and interferon (IFN) production through the cyclic GMP-AMP synthase – stimulator of IFN genes (cGAS-STING) pathway. Peripheral blood mononuclear cells (PBMCs) from the patient exhibited impaired signaling downstream of STING in response to the cGAS agonists 2’3’-cGAMP and dsDNA, as well as decreased IFN induction in response to herpes virus. VZV replication in patient PBMCs was found to be slightly increased compared to healthy controls. Overexpression of the variant AMFR p.R594C resulted in decreased K27-linked STING ubiquitination compared to expression of WT AMFR. This work links defective AMFR-STING signaling to severe VZV disease and hyperinflammation and suggests a direct role for cGAS-STING in control of viral infections in humans.
Biopsy-proven stromal fibrosis: what is the appropriated management approach?
Authors: Gopee-Ramanan Prasaanthan , Keshavarzi Sareh , Kulkarni Supriya , Grant Allison , Au Frederick , Ghai Sandeep , FREITAS VIVIANNE 
Published: August 2022

Abstract
Purpose: Assess the upgrade rate of biopsy-proven stromal fibrosis without associated atypiato inform the most appropriate management approach in patients with biopsy-proven stromal fibrosis without associated atypia.Materials and Methods: REB-approved consecutive retrospective review of patient’s data of imaging-guided biopsy-proven stromal fibrosis carried out between 2014 and 2019. The upgrade rate of malignancy and the imaging features of the upgraded cases on surgical excision were recorded. The results were correlated with surgical histopathology as the ground truth or an uneventful clinical and radiological follow-up of at least 2 years. Predictors for malignancy were examined, and appropriate statistical tests were applied. Results: Out of 9814 consecutive imaging-guided breast biopsies performed during the study period, 334 patients (4.8%) median age 52 years, had biopsy-proven stromal fibrosis without atypia and fulfilled the inclusion criteria, representing the study cohort. Out of 334 cases, 4 cases (1.2%) were upgraded to malignancy in the two years follow-up. Older patients (> 50 years) are associated with an upgrade to malignancy (p <0.001), and those with a personal history of breast cancer have a trend to upgrade to malignancy (p=0.066). No other clinical and imaging features are related to the malignancy upgrade.Conclusion: For benign radiology-pathology concordant stromal fibrosis on imaging-guided breast biopsy, the upgrade for biopsy results demonstrating stromal fibrosis without atypia is low at 1.2% but not 0; therefore diagnostic follow-up for 2 years as BI-RADS 3 (defined as <2% chance of malignancy) is warranted. Older patient age (> 50 years) and those with a personal history of breast cancer are subgroups of patients that may justify multidisciplinary discussion and possible re-sampling.
Mutated genes on ctDNA detecting postoperative recurrence presented reduced neoantigens in primary tumors in colorectal cancer cases
Authors: Nagayama Satoshi , Kobayashi Yuta , Fukunaga Mitsuko , Sakimura Shotaro , Sugimachi Keishi , Sasaki Shin , Masuda Takaaki , Mafune Ken-ichi , Oshima Masanobu , Shibata Tatsuhiro , Suzuki Yutaka , Mimori Koshi 
Published: August 2022

Abstract
It is essential to comprehend the specific traits of mutated genes observed commonly not only at primary sites but recurrent sites. They were applied to be monitoring targets of circulating tumor (ct) DNA in liquid biopsy assay for the detection of postoperative recurrence. In the current retrospective study, we conducted target resequencing of ctDNA using 47 plasma samples and established a cancer panel carrying the commonly mutated genes between primary and recurrent tumors. We found that mutated genes in ctDNA indicated immune-resistance traits with respect to the impaired ability to present neoantigens by loss of expression or binding affinity to HLA in the primary tumor. Compared with the estimated neoantigens from all mutated genes in primary tumors, the neoantigen peptides from commonly mutated genes between primary and recurrent tumors showed abundant and significant expression with no binding affinity to HLA. Therefore, ctDNA mutations can be frequently and postoperatively detected to identify recurrence; however, these mutated genes were derived from immune-tolerated clones owing to the loss of neoantigen presentation in primary CRC tumors.
Routine clinical measurements effective for the evaluation of the impact of multiple sclerosis on vision-related quality of life early in the disease course?
Authors: Tooulias Christos , Alonistiotis Dimitrios , Stavrakas Panagiotis , Papathanassiou Miltiadis , Karabatakis Vassilios , Kozobolis Vassilios , Kitsos Dimitrios , Theofilou Paraskevi , Voumvourakis Konstantinos , Androu Angeliki 
Published: August 2022

AbstractPURPOSE To determine how vision-related quality of life (QoL) correlates to mean and quadrant retinal nerve fiber layer thickness (RNFL) and mean standard deviation in visual field in mildly impaired patients with multiple sclerosis with (MSON) or without (MSNON) previous monocular optic neuritis. METHODS 25 MSNON patients, 14 MSON patients and 22 matched healthy controls were included in this study. Vision-related QoL was assessed with the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ). All patients underwent spectral domain optical coherence tomography (SD OCT) and Humphrey 30 − 2 visual field measurements. OCT images were segmented for the peripapillary retinal nerve fiber layer (pRNFL). RESULTS Vision-realted QoL was better for MSNON patients in comparison to MSON patients (p = 0,037) but worse in comparison to healthy controls (p < 0.001). Peripapillary and quadrant RNFL was not different for MSNON and MSON patients. MD was lower for MSNON patients in comparison to MSON patients (p = 0,047). Finally, vision-related QoL was not in any way associated with all measurements. CONCLUSION This study demonstrates that mildly impaired MS patients still experience a significant decrease of their vision-related QoL, independent of previous acute demyelinating events affecting their visual pathway. This result suggests a review and possible readjustment of the proposed time-frame of intervention. More sensitive than routine clinical measures are warranted in order to predict the impact of early clinical stages of MS on vision.
WITHDRAWN: Improving Deepfake Video Detection Using Data Augmentation Techniques
Authors: Doshi Harshil Dharmesh , Savla Akshat Nitin , Dholakia Sagar Sunil , Gandhi Hrim Deepak , Suratkar Shraddha , Kazi Faruk 
Published: August 2022

Abstract
The quantity and quality of the training data greatly influence the outcome of deep learning-based face-related tasks. However, gathering and labeling sufficient samples of adequate quality with a balanced distribution remains an expensive and laborious task. Hence, several data augmentation approaches have been extensively employed to enhance the quality and increase the quantity of the training dataset. This paper proposes a deep learning Convolutional Neural Network (CNN) based approach for Deepfake detection on the CelebDF dataset, in which several data augmentation techniques such as traditional augmentations, GridMask, face morphing, and style transfer are systematically examined to improve the capabilities of state-of-the-art Deepfake detection approaches. The problems and positive effects of each augmentation method are analyzed and compared in a concise yet informative manner. The trained model is then evaluated against an unseen test datum based on metrics like precision, recall, and F1-score, thereby deciding the best augmentation strategy for the chosen dataset.
Responses of Tetranychus urticae (Koch, 1836) and Neoseiulus californicus (McGregor, 1954) to the application of salicylic acid on bean cultivars.
Authors: Bertolo Fernanda de Oliveira de Andrade , Ott Ana Paula , Sant'Ana Josué 
Published: August 2022

Abstract

This study evaluated the influence of exogenous application of salicylic acid in common bean (Phaseolus vulgaris L.) in Fepagro26 and Garapiá cultivars on the biology and chemotaxis response of T. urticae and, N. californicus. The experiments were carried out in an acclimatized room at 25±ºC, UR 70 ± 10% and photophase for 16 hours. To verify the doses of AS in contrast to oviposition of T. urticae, three females of the mite were placed per plant/cage after 48 hours of application of the treatments: leaf with water, leaf with water + 1% alcohol, leaf with water + 5% alcohol, 0.5mM, 1mM and 2.5mM salicylic acid. Oviposition was monitored daily for 96 hours and the results were submitted to factorial ANOVA. Both cultivars showed interaction between AS doses and number of T. urticae eggs. The regression analysis between AS doses and number of eggs showed a correlation only for Garapiá (R2 = 99.54). The attractiveness of T.urticae was verified in a dual-choice olfactometer (Y), where the phytophage was attracted by the combination of the cultivar Garapiá and application of a 0.5 mM dose of AS (p < 0.01). For N. californicus, the attractiveness was also verified in a dual-choice olfactometer (Y), where only volatiles from cv. Fepagro26 plus the presence of T. urticae (48h after infestation) triggered responsive chemotaxis behavior. These results suggest that AS can be a promising tool in the integrated pest management of this phytophagous, but in the studied cultivars it influenced the chemotaxis orientation of the predator.
Exclusive breastfeeding intention and associated factors in pregnant women: findings from a population-based study
Authors: Zhao Hong , Ma Li , Mi Yang , Gao Ruoxuan , Wei Junxiang 
Published: August 2022

Abstract
Background
The benefits of breastfeeding especially exclusive breastfeeding have been well recognized.
Aim
To investigate the prevalence and influencing factors of exclusive breastfeeding intentions for the first six months among pregnant women.
Methods
A self-designed questionnaire was adopted to collect information on maternal intention on exclusive breastfeeding and other related social characteristics. The primary outcome was intention of mother on exclusively breastfeeding which derived by a response to the question “would you be will to breastfeed exclusively for the first 6 months?” Adjusted odds ratio (OR) with 95% confidence intervals were obtained by multiple logistic regression after adjusted by maternal age.
Findings:
A total of 2,479 pregnant women in the third trimester were interviewed. 60.8% of them planned to exclusively breastfeed during the first 6 months. After adjusted by maternal age, intentions to exclusively breastfeed was lower in mothers with a graduate degree (OR,0.70; 0.525–0.987). Mothers who received supports of exclusive breastfeeding from spouses and parents were more likely to intent to exclusively breastfeed than those not. The intention of exclusively breastfeed was higher among mothers (OR = 1.436, 1.199–1.719) who participated in breastfeeding courses during pregnancy were pregnant women independent influencing factors of breastfeeding intention in late pregnant women.
Conclusion
Over half of the pregnancy women showed an intention to exclusive breastfeeding for the first 6 months. Antenatal breastfeeding courses and supportive practices from family need to be enforced to improve mothers' and family members' perception about exclusive breastfeeding, in order to increase the rate and duration of exclusive breastfeeding.
Impact of postmastectomy radiation therapy on breast cancer patients according to pathologic nodal status after modern neoadjuvant chemotherapy
Authors: Kim Dowook , Kim Jin Ho , Kim In Ah , Chang Ji Hyun , Shin Kyung Hwan 
Published: August 2022

Abstract
Purpose:
The utility of postmastectomy radiation therapy (PMRT) for breast cancer patients after neoadjuvant chemotherapy (NAC) is highly controversial. This study evaluated the impact of PMRT according to pathologic nodal status after modern NAC.
Methods:
We retrospectively reviewed 682 patients with clinical stage II–III breast cancer who underwent NAC and mastectomy from 2013 to 2017. In total, 596 (87.4%) patients received PMRT, and 86 (12.6%) did not. We investigated the relationships among locoregional recurrence-free survival (LRRFS), disease-free survival (DFS), overall survival (OS), and various prognostic factors. Subgroup analyses were also performed to identify patients who may benefit from PMRT.
Results:
The median follow-up duration was 67 months. In ypN + patients (n = 368, 51.2%), PMRT showed significant benefits in terms of LRRFS, DFS, and OS (all p < 0.001). In multivariate analyses, histologic grade (HG) III (hazard ratio [HR] = 3.67, p = 0.002), lymphovascular invasion (LVI) (HR = 2.38, p = 0.045), and ypN2–3 (HR = 2.37, p = 0.02) were significant risk factors for poor LRRFS. In ypN1 patients with more than two prognostic factors among luminal/HER2-negative subtype, HG I-II, and absence of LVI, PMRT had no significant effect on LRRFS (p = 0.18). In ypN0 patients (n = 351, 48.8%), PMRT was not significantly associated with LRRFS, DFS, or OS. However, PMRT showed better LRRFS in triple-negative breast cancer (TNBC) patients (p = 0.03).
Conclusion:
PMRT had a major impact on treatment outcomes in patients with residual lymph nodes following NAC and mastectomy. Among ypN0 patients, PMRT may be beneficial only for those with TNBC.
Effect of Delay in SMS Worm Propagation in Mobile Network with Saturated Incidence Rate
Authors: Zhang Zizhen , V Madhusudanan , BSN Murty 
Published: August 2022

Abstract
Cell phones are getting increasingly well known. SMS worms spread themselves by sending messages, which can rapidly taint a large number of cell phones and cause incredible harm to clients. Consequently, it is critical to investigate and foresee the proliferation of SMS worms to diminish their expected danger. In this article, we propose a worm spread model in light of SMS, named SAID (Susceptible-Affected-Infected- suspended) with a saturated incidence rate and time delay. To precisely foresee the worm proliferation by means of SMS, first, we add the impacted state to address the condition of clients who have gotten the messages yet have not tapped the malignant connections. Second, since an infected node doesn't necessarily send pernicious messages to other people, a novel express, the suspended state, which gets some margin to affected node to infected node in mobile network. Specifically, nonlinear stability, hopf bifurcation and its direction and steadiness of the periodic solution not entirely settled by utilizing the centre manifold theorem. At last, a few numerical simulations are presented to check the analytical results.
Clinically Important Alterations in Pharmacogene Expression in Histologically Severe Nonalcoholic Fatty Liver Disease
Authors: Powell Nicholas , Liang Tiebing , Ipe Joseph , Cao Sha , Skaar Todd , Desta Zeruesenay , Qian Hui-Rong , Ebert Philip , Chen Yu , Thomas Melissa , Chalasani Naga 
Published: August 2022

Abstract
Background
Polypharmacy is common in patients with nonalcoholic fatty liver disease (NAFLD) and previous reports suggest that NAFLD is associated with altered drug disposition. This study aimed to determine if patients with histologically severe NAFLD are at risk for altered drug response by characterizing changes in hepatic mRNA expression of genes mediating drug disposition (pharmacogenes) across the spectrum of NAFLD severity.
Methods
We utilized hepatic RNA-seq from 93 patients with histologically staged NAFLD to test the relationship between pharmacogene expression and histological NAFLD Activity Score (NAS), fibrosis stage, and steatohepatitis (NASH). We then validated our results by meta-analysis of 16 studies, including ours.
Results
We identified 37 pharmacogene-NAFLD severity associations that were statistically significant after Bonferroni correction. Among all of the significant associations were 4 CYP enzymes (CYP2C19, CYP1B1, CYP2C8, CYP27B1), 3 phase II metabolic enzymes (GSTP1, GSTT1, GSTZ1), 6 ABC transporters (ABCB1, ABCB4, ABCB8, ABCC1, ABCC3, ABCC4), and 7 SLC transporters (SLC22A12, SLC16A1, SLCO3A1, SLC28A3, SLC2A4, SLC22A17, SLC6A6). We chose to validate CYP2C19 due to its actionability in clopidogrel prescribing and found that, compared to controls, it is significantly downregulated to 46% in NASH, to 58% in high NAS, and to 43% in severe fibrosis in our meta-analysis. In the regression analyses, CYP2C19 transcript abundance decreases to 69% with every 1 unit increase in fibrosis stage; reducing CYP2C19 mRNA expression levels by 77% in individuals with stage 4 fibrosis as compared to stage 0. With every 1 unit increase in NAS, CYP2C19 transcript abundance decreases to 83%; reducing CYP2C19 mRNA expression levels by 73% in individuals with a NAS of 7 as compared to 0. Hepatic CYP2C19 transcript abundance is 63% lower in NASH compared to those without.
Conclusions
Our data demonstrate that mRNA expression levels of several pharmacogenes are altered in livers of patients with NAFLD. Of these, the marked down-regulation of CYP2C19 presents a clear opportunity to further develop individualized treatment modifications for drugs that are sensitive substrates of the CYP2C19 enzyme (e.g., clopidogrel).
Privatization, Mixed Duopoly and Quality Differentiation with Excess Burden of Taxation
Authors: choi kangsik 
Published: August 2022

Abstract
Incorporating the excess burden of taxation into a mixed duopoly to evaluate privatization, we analyze competition of the public and private firms producing goods of different qualities between Cournot and Bertrand competition. When the only private firm offers a high quality, (i) under both Bertrand and Cournot competition, it is desirable to choose privatization if the the excess burden of taxation is sufficiently large, and vice versa; however, (ii) if the excess burden of taxation is intermediate, it is desirable to choose reversely with regard to the policy of privatization between Bertrand and Cournot competition. On the other hand, when the only public firm offers a high quality, (i) under Cournot competition, it is always desirable to choose mixed duopoly rather than privatization; (ii) under Bertrand competition, it is desirable to choose mixed duopoly if the excess burden of taxation is sufficiently large, and vice versa.JEL Classification: D43, L13, M21.
Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns
Authors: Hoti Qendresa , Akan Gokce , Tuncel Gulten , Evren Emine Unal , Evren Hakan , Suer Kaya , Sanlidag Tamer , Ergoren Mahmut Cerkez 
Published: August 2022

Abstract
Background
The most common symptoms of coronavirus infections are fever, cough, shortness of breath, headache, ache of joints, a loss of smell and loss of taste, and etc. Early studies suggested that smell and taste receptors were associated with pathogenic detection and immunity. Thus, we aimed to evaluate the expression profile of gene receptors that are related to taste, smell, and appetite control in COVID-19 patients and their putative correlation with SARS-CoV-19 variants.
Method
Gene expression levels of TAS1R2, TAS1R3, TAS2R38, OR51E1, LEPR, GHRL were analyzed in 100 COVID-19 patients and 100 SARS-CoV-2 RT-qPCR negative group.
Results
The expression levels of TAS1R2 and TAS1R3 genes were significantly decreased in COVID-19 patients who were infected with Delta variant. However, the TAS2R38 gene expression level was significantly lower when compared to the control group. The TAS1R2 gene expression was positively correlated with TAS1R3, and TAS2R38 genes (p = 0.001, p = 0.025, respectively).
Conclusion
TAS1R2, TAS1R3, and TAS2R38 gene expression levels were decreased in the Delta variant compared to the Omicron BA.1 variant in the studied groups. These results provided a significant clue for the temporary taste loss, especially in patients infected with the Delta variant, which is the most disruptive and symptomatic variant causing hospitalizations, and deaths compared to other variants may be because ACE2 is expressed in the taste buds and high replication of SARS-CoV-2 in the infected gustatory cells in the taste bud generates inflammation and then could eventually destroy the cells. This gustatory cell damage may cause malfunction of the gustatory system.