bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on plasma‐modified corn stover‐humic acid‐based superabsorbent resin
Authors: Liang Lanlan , Guo Yani , Wang Haoyu , Liao Zi , Zhang Jiahui , Wei Lijie , Hou Kang 
Published: November 2022

AbstractThis research aimed to prepare superabsorbent resin from agro‐mining waste, which is important for sustainable development and practical application in agriculture and forestry. Corn stover (CS), humic acid (HA), acrylic acid (AA), and acrylamide (AM) were used as raw materials to produce CS–HA‐based superabsorbent resin (p‐CS‐HA‐PAA) by plasma modification, and the optimum modification conditions were obtained. The superabsorbent resin was characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and contact angle analysis. The adsorption characteristics of the superabsorbent resin were analyzed by kinetic model fitting, and the performances were tested. The results showed that the water absorption capacity could reach 1106.9 g/g under the following optimal process conditions: a discharge time of 180 s, a discharge power of 40 W, and a discharge pressure of 20 Pa. The characterization confirmed that plasma modification could make the surface of the superabsorbent resin rougher, produce more and larger pores, and introduce more hydrophilic groups. The p‐CS‐HA‐PAA conformed to the pseudo‐second‐order kinetic equation and non‐Fickian intradiffusion process in aqueous solution. The chemical resistance, repeated liquid absorption, and water retention properties of the modified resin were better than those of the unmodified resin, which provided a viable way for industrial and agricultural applications.
A large‐scale targeted proteomics of plasma extracellular vesicles shows utility for prognosis prediction subtyping in colorectal cancer
Authors: Kasahara Keiko , Narumi Ryohei , Nagayama Satoshi , Masuda Keiko , Esaki Tsuyoshi , Obama Kazutaka , Tomonaga Takeshi , Sakai Yoshiharu , Shimizu Yoshihiro , Adachi Jun 
Published: November 2022

AbstractPurposeThe pathogenesis of cancers depends on the molecular background of each individual patient. Therefore, verifying as many biomarkers as possible and clarifying their relationships with each disease status would be very valuable. We performed a large‐scale targeted proteomics analysis of plasma extracellular vesicles (EVs) that may affect tumor progression and/or therapeutic resistance.Experimental designPlasma EVs from 59 were collected patients with colorectal cancer (CRC) and 59 healthy controls (HC) in cohort 1, and 150 patients with CRC in cohort 2 for the large‐scale targeted proteomics analysis of 457 proteins as candidate CRC markers. The Mann–Whitney‐Wilcoxon test and random forest model were applied in cohort 1 to select promising markers. Consensus clustering was applied to classify patients with CRC in cohort 2. The Kaplan–Meier method and Cox regression analysis were performed to identify potential molecular factors contributing to the overall survival (OS) of patients.ResultsIn the analysis of cohort 1, 99 proteins were associated with CRC. The analysis of cohort 2 revealed two clusters showing significant differences in OS (p = 0.017). Twelve proteins, including alpha‐1‐acid glycoprotein 1 (ORM1), were suggested to be associated with the identified CRC subtypes, and ORM1 was shown to significantly contribute to OS, suggesting that ORM1 might be one of the factors closely related to the OS.ConclusionsThe study identified two novel subtypes of CRC, which exhibit differences in OS, as well as important biomarker proteins that are closely related to the identified subtypes. Liquid biopsy assessment with targeted proteomics analysis was proposed to be crucial for predicting the CRC prognosis.
Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation
Authors: Perez Fernando , Kotecha Nikki , Lavoie Brigitte , Mawe Gary M. , Patel Bhavik Anil 
Published: November 2022

AbstractElectrochemical arrays were used to measure the overflow of serotonin (5‐HT) and melatonin (MEL) from the entire colon of healthy mice and mice with chemical‐induced inflammatory bowel disease (IBD), to understand the interplay between inflammation and colonic function. We show that 5‐HT overflow is increased, whilst MEL levels are reduced, in inflamed tissues. The levels of MEL are increased at the interface between healthy and inflamed regions within the colon and may limit the spread of inflammation. Understanding the interplay between inflammation and mucosal epithelial signalling can provide key insight into colonic function and aid the development of effective therapeutic strategies to treat gastrointestinal diseases.
Metal Complexes for Cancer Sonodynamic Therapy
Authors: Mandal Arif Ali , Kushwaha Rajesh , Yadav Ashish Kumar , Banerjee Samya 
Published: November 2022

AbstractSonodynamic therapy (SDT) for cancer treatment is gaining attention owing to its non‐invasive property and ultrasound‘s (US) deep tissue penetration ability. In SDT, US activates the sonosensitizer at the target deep‐seated tumors to generate reactive oxygen species (ROS), which ultimately damage tumors. However, drawbacks such as insufficient ROS production, aggregation of sonosensitizer, off‐target side effects, etc., of the current organic/nanomaterial‐based sonosensitizers limit the effectiveness of cancer SDT. Very recently, metal complexes with tunable physiochemical properties (such as sonostability, HOMO to LUMO energy gap, ROS generation ability, aqueous solubility, emission, etc.) have been devised as effective sonosensitizers, which could overcome the limitations of organic/nanomaterial‐based sonosensitizers. This concept introduces all the reported metal‐based sonosensitizers and delineates the prospects of metal complexes in cancer sonodynamic therapy. This new concept of metal‐based sonosensitizer can deliver next‐generation cancer drugs.
Flow‐Chemistry‐Enabled Synthesis of 5‐Diethylboryl‐2,3′‐bipyridine and Its Self‐Assembly Dynamics
Authors: Wakabayashi Shigeharu , Takumi Masahiro , Kamio Shintaro , Wakioka Masayuki , Ohki Yasuhiro , Nagaki Aiichiro 
Published: November 2022

Abstract5‐Diethylboryl‐2,3′‐bipyridine (1), which is inaccessible by conventional batch methods, was synthesized by using a flow microreactor. Compound 1 was obtained as an equilibrium mixture of a cyclic trimer and a cyclic tetramer in solution, the latter of which was crystallized in benzene by vapor diffusion of hexane at 7 °C. The dynamic nature of this system was confirmed by solvent‐ and concentration‐dependent experiments. Notably, the dynamics was verified by using flow NMR spectroscopy, which revealed that the time required to reach equilibrium was influenced by the solvent ratio (<18 s, 24–28 s, and 34–42 s in 2 : 1, 1 : 1, and 1 : 2 mixtures of [D6]acetone and C6D6, respectively). Compound 1 and 3‐[4′‐(diethylboryl)phenyl]pyridine (2) exhibited different self‐assembly behavior in solution and crystals. Density functional theory calculations suggested that this difference was largely due to enhanced planarity between two consecutive aromatic rings.
Combination of Deauville score and quantitative positron emission tomography parameters as a predictive tool of anti‐CD19 chimeric antigen receptor T‐cell efficacy
Authors: Guidetti Anna , Dodero Anna , Lorenzoni Alice , Pizzamiglio Sara , Argiroffi Giovanni , Chiappella Annalisa , Bagnoli Filippo , Marasco Vincenzo , Carniti Cristiana , Monfrini Chiara , Seregni Ettore , Pennisi Martina , Verderio Paolo , Alessi Alessandra , Corradini Paolo 
Published: November 2022

AbstractBackgroundAutologous anti‐CD19 chimeric antigen receptor (CAR) T‐cell therapy is an effective treatment for approximately 40% of relapsed/refractory large B cell lymphomas (LBCL), and early identification of patients at risk for relapse or progression after CAR T‐cell therapy represents a clinical need.MethodsThe authors conducted a single‐center prospective study on 47 relapsed/refractory LBCL receiving CAR T‐cell therapy to evaluate the prognostic value of baseline and after infusion 18F‐fluorodeoxyglucose positron emission tomography (PET)‐computed tomography. Qualitative and quantitative metabolic parameters were evaluated before lymphodepletion, at day 30 and 90 post‐infusion.ResultsDeep variation of standardized uptake value (SUV)mean between baseline and day 30 correlated with response at day 90 (hazard ratio [HR], 1.49; 95% confidence interval [CI], 1.01–2.2); p = .04) and better progression‐free survival (PFS) (HR, 0.63; 95% CI, 0.41–0.97); p = .04). In the overall population, 1‐year PFS was 63% for Deauville score (DS)1–3 and 39% for DS4–5 patients, respectively (p = .02), however, the prognostic role of DS was lost when survivals are analyzed by considering 38 patients not progressing at 30 days. In these patients, in partial response or stable disease, the combination of DS and variation of SUVmean allowed identification of three groups with different prognosis: patients with DS1–3 and those with DS4–5 and decreased SUVmean had similar 1‐year PFS of 62% and 61%, whereas patients with DS4–5 and increased SUVmean had a poorer 1‐year PFS of 33% (p = .04).ConclusionsPET parameters and association of DS and variation of SUVmean at 30 days could help in identify patients at high risk of CAR T‐cell failure.Lay summary

This is a single‐center prospective study on 47 lymphoma patients receiving commercial chimeric antigen receptor T‐cell therapy aimed to evaluate the prognostic value of baseline and after infusion 18F‐fluorodeoxyglucose positron emission tomography.

Among patients in partial remission or stable disease at day 30, the authors observed two subgroups with significantly different prognosis; patients with Deauville score (DS)4–5 and a concomitant reduction of standardized uptake value (SUV)mean had higher probability of long‐lasting response than those with DS4–5 and an increase of SUVmean.
Efficient Interrogation of the Kinetic Barriers Demarcating Catalytic States of a Tyrosine Kinase with Optimal Physical Descriptors and Mixture Models
Authors: Dutta Pallab , Sengupta Neelanjana 
Published: November 2022

AbstractComputer simulations are increasingly used to access thermo‐kinetic information underlying structural transformation of protein kinases. Such information are necessary to probe their roles in disease progression and interactions with drug targets. However, the investigations are frequently challenged by forbiddingly high computational expense, and by the lack of standard protocols for the design of low dimensional physical descriptors that encode system features important for transitions. Here, we consider the demarcating characteristics of the different states of Abelson tyrosine kinase associated with distinct catalytic activity to construct a set of physically meaningful, orthogonal collective variables that preserve the slow modes of the system. Independent sampling of each metastable state is followed by the estimation of global partition function along the appropriate physical descriptors using the modified Expectation Maximized Molecular Dynamics method. The resultant free energy barriers are in excellent agreement with experimentally known rate‐limiting dynamics and activation energy computed with conventional enhanced sampling methods. We discuss possible directions for further development and applications.
Enhanced Energy Storage Properties of Bi(Mg0.5Zr0.5)O3 Modified Ba0.9Sr0.1TiO3 Ceramics
Authors: Xia Zhichao , Pan Yongqi , Chen Yi , Xu Zunping 
Published: November 2022

AbstractLead‐free (1–x)Ba0.9Sr0.1TiO3–xBi(Mg0.5Zr0.5)O3 ((1–x)BST–xBMZ, x = 0–0.15) ceramics are synthesized via citrate combustion process. The grain size is reduced and slimmer hysteresis loops are realized as addition of BMZ. (1–x)BST–xBMZ ceramics exhibit typical relaxor characteristics as x increases. The recoverable energy storage density (Wre = 2.1 J cm−3) and efficiency (η = 88%) are obtained for 0.9BST‐0.1BMZ sample. The energy storage properties of 0.9BST‐0.1BMZ ceramic show excellent frequency stability (Wre varies 4.5% and η varies 1.8% at 5–100 Hz). Moreover, as the temperature increases from 25 °C to 100 °C, the variation of Wre is 7.1% and η keeps unchanged (88%) at 100 kV cm−1.
Class‐F power oscillator based on complementary split ring resonator for sub‐6 GHz fifth generation and multistandard applications
Authors: Mansour Marwa , Mansour Islam , Aboualalaa Mohamed 
Published: November 2022

SummaryA coupled complementary split‐ring resonator (CSRR) has been proposed. The proposed resonator consists of two coupled 50‐Ω transmission lines and complementary split rings in the ground plane (bottom layer) as defected ground structure (DGS). The proposed bandpass filter (BPF) has a measured stopband attenuation loss of less than −20 dB in the frequency band between 2.3 and 2.9 GHz and a low insertion loss of 1.15 dB. The measurement is carried by a VNA (vector network analyzer) meter of model ZVA67. Then, the proposed resonator (BPF) is utilized with an active device (SiGe BFP 640) as an output matching network of a class‐F oscillator. Fundamentally, this research aims to design and model an optimum achievement of BPF for optimum oscillator performance. The design simulation of the CSRR oscillator has been obtained by ADS and CST programs. The proposed band pass filter is designed and fabricated on a Rogers (RO4003C) micro‐strip material printed with a dielectric constant epsilon of 3.38 and a thickness of 0.813 mm. Depending on this study, the oscillator displays a minimum phase noise of −109.3 dBc/Hz at 1 MHz offset frequency and maximum dBm output power equals 13.4 dBm at 2.45 GHz oscillation frequency. The power dispassion of the proposed oscillator equals 8.3 mW from a 2 V supply voltage. The obtained maximum dBm output power and minimum phase noise is a benefit for power charger wireless applications, sub‐6 GHz fifth generation applications, and multistandard applications.
Evaluating the impact of COVID‐19 on severity at admission and response to inpatient treatment for adult and adolescent patients with eating disorders
Authors: Schreyer Colleen C. , Vanzhula Irina A. , Guarda Angela S. 
Published: November 2022

AbstractObjectiveThe COVID‐19 pandemic has been associated with increased hospitalization rates and worsened symptom severity in patients with eating disorders (ED), but most studies focused exclusively on adolescents. Further, research evaluating the impact of COVID‐19 on response to inpatient treatment for ED is limited. This study aimed to compare demographic characteristics, symptom severity at admission, and discharge outcomes for adult and adolescent inpatients with EDs admitted before and after onset of the COVID‐19 pandemic. We expected the post‐COVID cohort would report elevated symptomatology and poorer response to treatment compared to the pre‐COVID cohort and that this effect would be amplified for adolescents.MethodPatients were consecutively hospitalized adults and adolescents treated in a specialized behavioral integrated inpatient‐partial hospitalization program for eating disorders between March 2018 and March 2022 (N = 261).ResultsThe effect of COVID‐19 on symptomatology was moderated by age group such that adolescents in the post‐COVID cohort, but not adults, reported higher levels of eating disorder and depressive symptoms compared to the pre‐COVID cohort. No group differences were observed for discharge outcomes (rate of weight gain, length of stay, or percent target weight).DiscussionFindings with respect to elevated symptomatology in adolescents but not adults may reflect the particularly negative impact of social isolation on adolescents. Future research is needed to assess the impact of COVID‐19 on long‐term treatment outcomes including relapse at 1‐year, as well as the potential impact of COVID‐19 on treatment availability for chronically ill adults or those with public insurance.Public SignificancePatients with eating disorders (ED) admitted to a specialty inpatient program after the start of the COVID‐19 pandemic were younger and more likely to be male than those admitted pre‐pandemic. Adolescents admitted post‐COVID, but not adults, reported elevated ED and depressive symptoms compared to the pre‐COVID cohort. Group differences were not observed for treatment response. Future research should evaluate the impact of COVID‐19 on relapse risk in EDs.
Thermal and combustion behaviors of aluminum/manganese dioxide/fluoroelastomer terpolymer nanothermite
Authors: Song Jiaxing , Duan Fei , Chen Jialin , Wang Guannan , Tian Quanwei , Feng Jingkai 
Published: November 2022

AbstractFluoroelastomer has received increasing attention for energetic materials application due to its high fluorine contents. Different contents (0 wt%–30 wt%) of poly(VDF‐ter‐HFP‐ter‐TFE) terpolymer are added into Al/MnO2 nanothermite. The peak exothermic temperature of thermite reaction for Al/MnO2 system is about 554°C with 1070 Jg−1 heat release. After adding terpolymer, it mainly exists in the gap among Al nanoparticles and MnO2 nanorods, and react with Al and MnO2 at the range of 350 to 540°C before the occurrence of the thermite reaction. 10 wt% terpolymer has relatively little effect on the thermite reaction, but for the samples with higher terpolymer content, more nanothermite components react with terpolymer at an early stage. Ignition and combustion performance show terpolymer can reduce ignition current threshold by up to 9.82% and increase combustion duration time at least several times. The potential reasons for the above results are analyzed. This work can shed light on the application of fluoroelastomer in energetic‐materials.
Effects of glycerol and sorbitol on a novel biodegradable edible film based on Malva sylvestris flower gum
Authors: Jaderi Zeinab , Tabatabaee Yazdi Fardieh , Mortazavi Seyed Ali , Koocheki Arash 
Published: November 2022

AbstractThere has been an increasing interest in the investigation of novel eco‐friendly packaging materials. An edible film based on Malva sylvestris flower gum was fabricated with 40%, 50%, and 60% glycerol and sorbitol using casting method. FTIR analysis was applied to identify the functional groups of films with different concentrations of plasticizers. The lightness of the samples did not affect upon increasing the sorbitol and glycerol; nevertheless, the samples tended to be green and yellow. SEM images indicated that glycerol‐based films enjoy heterogeneous and porous surfaces compared to the sorbitol‐based samples. Although Tensile Strength and Young's Modulus characteristics declined considerably (p < .05) upon plasticizer addition, elongation at break increased by more than 10% in glycerol‐based samples. A significant (p < .05) decrement was observed in the density of film strips via the addition of glycerol and sorbitol. Moisture content of films incorporated with both plasticizers saw a considerable improvement (p < .05) upon increasing the plasticizer concentration from 40% to 60% and is ascribed to the water‐holding capacity of plasticizers. Water contact angle and water solubility increased via plasticizer supplementation, which is attributed to the hydrophilic characteristic of glycerol and sorbitol, are in line with SEM analysis.
Cellular toxicities of gadolinium‐based contrast agents used in magnetic resonance imaging
Authors: Akbas Ece , Unal Fatma , Yuzbasioglu Deniz 
Published: November 2022

AbstractContrast agents have been used in magnetic resonance imaging (MRI) as a radiological method. Gadolinium‐based contrast agents (GBCAs), because of their paramagnetic characteristics, are the ones mostly used in MRI to increase signal intensity. However, the use of contrast media has raised concerns on cellular toxic risks of these agents. Studies showed the accumulation of gadolinium after injection to humans with or without renal impairment. Also, there are findings obtained under in vitro and/or in vivo conditions that revealed conflicting results for their cytotoxic and genotoxic effects. Some of them declared damage in cells and genetic material; some others did not. Abnormal cell growth and genetic aberration are critical because they may lead to carcinogenesis in somatic cells or may be transferred to the next generations through germ cells. Therefore, understanding the effect of GBCAs on cells is important for their safer usage in clinical administrations to generate high‐quality contrast‐enhanced magnetic resonance images. Because of all these reasons, cellular toxicities—mainly genotoxic and cytotoxic effects—of GBCAs were reviewed in this paper.
Influence of Calcineurin Inhibitors and Genetic Polymorphism of Transporters on Enterohepatic Circulation and Exposure of Mycophenolic Acid in Chinese Adult Renal Allograft Recipients
Authors: Sun Sha‐Sha , Shao Kun , Lu Jia‐Qian , An Hui‐Min , Shi Hao‐Qiang , Zhou Pei‐Jun , Chen Bing 
Published: November 2022

AbstractThere is significant enterohepatic circulation (EHC) during the disposition of mycophenolic acid (MPA). The aim of this study was to elucidate factors influencing the EHC of MPA in Chinese adult renal allograft recipients. After 2 weeks of therapy with mycophenolate mofetil or enteric‐coated mycophenolate sodium, blood samples were collected from 125 patients at 0 to 12 hours post‐administration and MPA concentrations were determined. The influence of calcineurin inhibitors (CNIs) and genetic polymorphisms on MPA exposure and EHC was studied. The Shapley additive explanations method was used to estimate the impact of various factors on the area under the plasma drug concentration–time curve (AUC0–12h) for MPA. An extreme gradient boosting (XGboost) machine learning‐based model was established to predict AUC0–12h. Results showed that the dose‐normalized AUC6–12h (dn‐AUC6–12h) of MPA was significantly lower in patients co‐administered with cyclosporine (CsA) than in patients co‐administered with tacrolimus (TAC) (P < .05). For patients co‐administered with TAC, patients with ABCC2 C‐24T CC or SLCO1B1 T521C TT genotypes had significantly higher values of dn‐AUC6‐12h (P < .05). Patients with SLCO1B3 334T/699G alleles had significantly lower dn‐AUC6–12h values than homozygotes (P < .05). By introducing body weight, age, and EHC‐related factors, including co‐administered CNIs and genetic polymorphism of drug transporters, as covariates in the XGboost machine learning model, the prediction performance of AUC0–12h for MPA in Chinese adult renal allograft recipients can be improved.
Investigation of Photocatalyst Composites for Pollutant Degradation in a Microslit Reactor Utilizing High Throughput Screening Techniques
Authors: Engelhardt Tony B. , Schmitz‐Stöwe Sabine , Schwarz Thomas , Stöwe Klaus 
Published: November 2022

AbstractThe high‐throughput screening investigations on TiO2 based photocatalyst composites presented here have been carried out in a 60‐fold parallel photoreactor. Additional catalyst testing was performed in a microslit reactor system with immobilized catalysts. For further enhancing the photocatalytic activity of TiO2 (P25), composites of P25 and, for example, Bi2O3, CeO2, g‐C3N4, WO3 or ZnO were formulated in different nominal molar ratios. The catalysts' performances were assessed by their conversion of 17α‐ethinyl estradiol (EE2) in aqueous solutions, determined by LC–MS. Findings show rapid EE2 conversions in short residence times. The extensive testing of catalysts led to the conclusion that the photocatalytic conversion is rather a function of residence time than a function of the materials utilized. This makes adequate process development seem more important than material development. The novelty of this contribution lies in the unique combination of testing a wide range of composite catalysts in a unique microreactor geometry.