bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in gender of first and senior authors of articles published in JMIRO
Authors: Batumalai Vikneswary , Kumar Shivani , Sundaresan Puma 
Published: November 2022

AbstractIntroductionDespite progress of women in science and medicine, women remain underrepresented in academic publication. The aim of this study was to evaluate potential gender differences in women authorship in the Journal of Medical Imaging and Radiation Oncology (JMIRO).MethodsGender of the first and senior author of all articles published in JMIRO between 2012 and 2021 were examined. Changes over time and differences among groups were compared using the chi‐square test.ResultsIn total, 1,138 articles were assessed. Women were first and senior authors on 34% and 25% of all articles respectively. The proportion of women as first author was 30%, 41% and 36% for medical imaging (MI), radiation oncology (RO) and combined MI/RO articles respectively. Similarly, the proportion of women as senior author was lower than men at 22%, 32% and 23% for MI, RO and MI/RO articles respectively. Women first authorship over the study period remained stable from 2014 (36%) to 2020 (38%); however, it decreased dramatically in 2021 to 28%. There was a trend of increasing women senior authorship from 2013 (15%) to 2017 (35%) but decreased to 23% in 2021.ConclusionOver the past 10 years of publications, one in three first authors were women and only one in four senior authors were women. The acknowledgement of this imbalance is the first step to pave the way towards addressing underlying systemic issues related to academic publication and disparities in gender and other inequities.
Chinese expert consensus on the diagnosis and treatment of HER2‐altered non–small cell lung cancer
Authors: Zhang Shirong , Wang Wenxian , Xu Chunwei , Zhang Yongchang , Cai Xiuyu , Wang Qian , Song Zhengbo , Li Ziming , Yu Jinpu , Zhong Wenzhao , Wang Zhijie , Liu Jingjing , Liu Anwen , Li Wen , Zhan Ping , Liu Hongbing , Lv Tangfeng , Miao Liyun , Min Lingfeng , Lin Gen , Huang Long , Yuan Jingping , Jiang Zhansheng , Pu Xingxiang , Rao Chuangzhou , Lv Dongqing , Yu Zongyang , Li Xiaoyan , Tang Chuanhao , Zhou Chengzhi , Zhang Junping , Guo Hui , Chu Qian , Meng Rui , Liu Xuewen , Wu Jingxun , Zhou Jin , Zhu Zhengfei , Pan Weiwei , Dong Xiaowei , Pang Fei , Wang Kai , Yao Chao , Lin Guomin , Li Site , Yang Zhi , Luo Jiancheng , Jia Hongtao , Nie Xiuqing , Wang Liping , Zhu Youcai , Hu Xiao , Xie Yanru , Lin Xinqing , Cai Jing , Xia Yang , Feng Huijing , Wang Lin , Du Yingying , Yao Wang , Shi Xuefei , Niu Xiaomin , Yuan Dongmei , Yao Yanwen , Kang Jing , Zhang Jiatao , Zhang Chao , Gao Wenbin , Huang Jianhui , Zhang Yinbin , Sun Pingli , Wang Hong , Ye Mingxiang , Wang Dong , Wang Zhaofeng , Wan Bing , Lv Donglai , Yu Genhua , Shi Lin , Xia Yuanli , Gao Feng , Zhang Xiaochen , Xu Tao , Zhou Wei , Wang Haixia , Liu Zhefeng , Yang Nong , Wu Lin , Wang Qiming , Wang Guansong , Hong Zhuan , Wang Jiandong , Fang Meiyu , Fang Yong , Zhang Yiping , Song Yong , Ma Shenglin , Fang Wenfeng , Lu Yuanzhi 
Published: November 2022

AbstractHuman epidermal growth factor receptor 2 (HER2) possesses tyrosine kinase activity and participates in cell growth, differentiation and migration, and survival. Its alterations, mainly including mutations, amplifications, and overexpression are associated with poor prognosis and are one of the major drivers in non–small cell lung cancer (NSCLC). Several clinical trials had been investigating on the treatments of HER2‐altered NSCLC, including conventional chemotherapy, programmed death 1 (PD‐1) inhibitors, tyrosine kinase inhibitors (TKIs) and antibody‐drug conjugates (ADCs), however, the results were either disappointing or encouraging, but inconsistent. Trastuzumab deruxtecan (T‐DXd) was recently approved by the Food and Drug Administration as the first targeted agent for treating HER2‐mutant NSCLC. Effective screening of patients is the key to the clinical application of HER2‐targeted agents such as TKIs and ADCs. Various testing methods are nowadays available, including polymerase chain reaction (PCR), next‐generation sequencing (NGS), fluorescence in situ hybridization (FISH), immunohistochemistry (IHC), etc. Each method has its pros and cons and should be reasonably assigned to appropriate patients for diagnosis and guiding treatment decisions. To help standardize the clinical workflow, our expert group reached a consensus on the clinical management of HER2‐altered NSCLC, focusing on the diagnosis and treatment strategies.
Is resting and sleeping well helpful to job crafting? Daily relationship between recovery experiences, sleep quality, feelings of recovery, and job crafting
Authors: Hur Won‐Moo , Shin Yuhyung 
Published: November 2022

AbstractDespite mounting research on job crafting, relatively little attention has been paid to the roles of recovery and sleep in daily job crafting. Drawing on self‐regulation theory, we proposed that overnight recovery experiences (i.e. relaxation and psychological detachment) and sleep quality replenish the self‐regulatory resources necessary for day‐level job crafting. We further isolated feelings of recovery as a self‐regulatory resource that mediates the relationship between overnight recovery experiences and sleep quality and day‐level job crafting. The results of the experience sampling method conducted with 126 employees for 5 consecutive working days revealed that overnight recovery experiences and sleep quality positively affected day‐level promotion‐oriented job crafting through increased feelings of recovery in the morning. However, we found no significant indirect effect of overnight recovery experiences and sleep quality on day‐level prevention‐oriented job crafting. These findings provide novel insights into the roles of recovery experiences and sleep quality in the context of job crafting.
Analysis of inhibitors of the anoctamin‐1 chloride channel (transmembrane member 16A, TMEM16A) reveals indirect mechanisms involving alterations in calcium signalling
Authors: Genovese Michele , Buccirossi Martina , Guidone Daniela , De Cegli Rossella , Sarnataro Sergio , di Bernardo Diego , Galietta Luis J. V. 
Published: November 2022

Background and PurposePharmacological inhibitors of TMEM16A (ANO1), a Ca2+‐activated Cl− channel, are important tools of research and possible therapeutic agents acting on smooth muscle, airway epithelia and cancer cells. We tested a panel of TMEM16A inhibitors, including CaCCinh‐A01, niclosamide, MONNA, Ani9 and niflumic acid, to evaluate their possible effect on intracellular Ca2+.Experimental ApproachWe recorded cytosolic Ca2+ increase elicited with UTP, ionomycin or IP3 uncaging.Key ResultsUnexpectedly, we found that all compounds, except for Ani9, markedly decreased intracellular Ca2+ elevation induced by stimuli acting on intracellular Ca2+ stores. These effects were similarly observed in cells with and without TMEM16A expression. We investigated in more detail the mechanism of action of niclosamide and CaCCinh‐A01. Acute addition of niclosamide directly increased intracellular Ca2+, an activity consistent with inhibition of the SERCA pump. In contrast to niclosamide, CaCCinh‐A01 did not elevate intracellular Ca2+, thus implying a different mechanism of action, possibly a block of inositol triphosphate receptors.Conclusions and ImplicationsMost TMEM16A inhibitors are endowed with indirect effects mediated by alteration of intracellular Ca2+ handling, which may in part preclude their use as TMEM16A research tools.
The association between and development of school enjoyment and general knowledge
Authors: Jirout Jamie J. , Ruzek Erik , Vitiello Virginia E. , Whittaker Jessica , Pianta Robert C. 
Published: November 2022

AbstractLearning environments can support the development of foundational knowledge and promote children's attitudes toward learning and school. This study explores the relation between school enjoyment and general knowledge from preschool (2016–2017) to kindergarten (2017–2018) in 1359 children (Mage = 55, 61 months, female = 50%; 58.5% Hispanic, 17% Black, 10% Asian, 10% White, 5% multiracial/other; linguistically diverse). Cross‐lagged panel models showed significant bidirectional associations between preschool enjoyment and change in general knowledge from preschool to kindergarten with a standardized coefficient of β = .21 (p < .001) and associations between preschool general knowledge and change in enjoyment, β = .09 (p = .015). Exploratory analyses with teacher characteristics and demographic subgroup comparisons are discussed. These associations suggest the potential intervention strategy of promoting early school enjoyment to support broader academic development.
Smaller, more diverse and on the way to the top: Rapid community shifts of montane wild bees within an extraordinary hot decade
Authors: Maihoff Fabienne , Friess Nicolas , Hoiss Bernhard , Schmid‐Egger Christian , Kerner Janika , Neumayer Johann , Hopfenmüller Sebastian , Bässler Claus , Müller Jörg , Classen Alice 
Published: November 2022

AbstractAimGlobal warming is assumed to restructure mountain insect communities in space and time. Theory and observations along climate gradients predict that insect abundance and richness, especially of small‐bodied species, will increase with increasing temperature. However, the specific responses of single species to rising temperatures, such as spatial range shifts, also alter communities, calling for intensive monitoring of real‐world communities over time.LocationGerman Alps and pre‐alpine forests in south‐east Germany.MethodsWe empirically examined the temporal and spatial change in wild bee communities and its drivers along two largely well‐protected elevational gradients (alpine grassland vs. pre‐alpine forest), each sampled twice within the last decade.ResultsWe detected clear abundance‐based upward shifts in bee communities, particularly in cold‐adapted bumble bee species, demonstrating the speed with which mobile organisms can respond to climatic changes. Mean annual temperature was identified as the main driver of species richness in both regions. Accordingly, and in large overlap with expectations under climate warming, we detected an increase in bee richness and abundance, and an increase in small‐bodied species in low‐ and mid‐elevations along the grassland gradient. Community responses in the pre‐alpine forest gradient were only partly consistent with community responses in alpine grasslands.Main ConclusionIn well‐protected temperate mountain regions, small‐bodied bees may initially profit from warming temperatures, by getting more abundant and diverse. Less severe warming, and differences in habitat openness along the forested gradient, however, might moderate species responses. Our study further highlights the utility of standardized abundance data for revealing rapid changes in bee communities over only one decade.
An evolving feature weighting framework for radial basis function neural network models
Authors: Muda Muhammad Zaiyad , Solis Adrian R. , Panoutsos George 
Published: November 2022

AbstractVia Granular Computing (GrC), one can create effective computational frameworks for obtaining information from data, motivated by the human perception of combining similar objects. Combining knowledge gained via GrC with a Fuzzy inference engine (Neural‐Fuzzy) enable us to develop a transparent system. While weighting variables based on their importance during the iterative data granulation process has been proposed before (W‐GrC), there is no work in the literature to demonstrate effectiveness and impact on Type‐2 Fuzzy Logic systems (T2‐FLS). The main contribution of this paper is to extend W‐GrC, for the first time, to both Type‐1 and Type‐2 models known as Radial Basis Function Neural Network (RBFNN) and General Type‐2 Radial Basis Function Neural Network (GT2‐RBFNN). The proposed framework is validated using popular datasets: Iris, Wine, Breast Cancer, Heart and Cardiotocography. Results show that with the appropriate selection of feature weight parameter, the new computational framework achieves better classification accuracy outcomes. In addition, we also introduce in this research work an investigation on the modelling structure's interpretability (via Nauck's index) where it is shown that a good balance of interpretability and accuracy can be maintained.
The new “corporate state”: The meshing of corporate and political power and the erosion of democratic accountability in the UK
Authors: Cooper Christine , Tweedie Jonathan , Andrew Jane , Baker Max 
Published: November 2022

AbstractThis article argues that since 1979, in the UK, democratic accountability has been eroded—in spite of the far greater emphasis formally placed upon meeting the ideal of transparent workings of power. First, we look at structural reforms made to the government by Margaret Thatcher and how these led to an attenuation of ministerial accountability. Second, we consider how the increasing role of accountants and management consultants in formulating and delivering government policy subverts the ideal of a disinterested bureaucracy and results in a blurring of private (for‐profit) and public interests.
Freshwater mussel conservation: A global horizon scan of emerging threats and opportunities
Authors: Aldridge David C. , Ollard Isobel S. , Bespalaya Yulia V. , Bolotov Ivan N. , Douda Karel , Geist Juergen , Haag Wendell R. , Klunzinger Michael W. , Lopes‐Lima Manuel , Mlambo Musa C. , Riccardi Nicoletta , Sousa Ronaldo , Strayer David L. , Torres Santiago H. , Vaughn Caryn C. , Zając Tadeusz , Zieritz Alexandra 
Published: November 2022

AbstractWe identified 14 emerging and poorly understood threats and opportunities for addressing the global conservation of freshwater mussels over the next decade. A panel of 17 researchers and stakeholders from six continents submitted a total of 56 topics that were ranked and prioritized using a consensus‐building Delphi technique. Our 14 priority topics fell into five broad themes (autecology, population dynamics, global stressors, global diversity, and ecosystem services) and included understanding diets throughout mussel life history; identifying the drivers of population declines; defining metrics for quantifying mussel health; assessing the role of predators, parasites, and disease; informed guidance on the risks and opportunities for captive breeding and translocations; the loss of mussel–fish co‐evolutionary relationships; assessing the effects of increasing surface water changes; understanding the effects of sand and aggregate mining; understanding the effects of drug pollution and other emerging contaminants such as nanomaterials; appreciating the threats and opportunities arising from river restoration; conserving understudied hotspots by building local capacity through the principles of decolonization; identifying appropriate taxonomic units for conservation; improved quantification of the ecosystem services provided by mussels; and understanding how many mussels are enough to provide these services. Solutions for addressing the topics ranged from ecological studies to technological advances and socio‐political engagement. Prioritization of our topics can help to drive a proactive approach to the conservation of this declining group which provides a multitude of important ecosystem services.
Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo‐controlled, double‐blind study
Authors: Akasaka Hiroshi , Nakagami Hironori , Sugimoto Ken , Yasunobe Yukiko , Minami Tomohiro , Fujimoto Taku , Yamamoto Koichi , Hara Chikako , Shiraki Akihiko , Nishida Kohji , Asano Kento , Kanou Masanobu , Yamana Kei , Imai Shin‐ichiro , Rakugi Hiromi 
Published: November 2022

ObjectiveNicotinamide adenine dinucleotide regulates various biological processes. Nicotinamide mononucleotide (NMN) increases its intracellular levels and counteracts age‐associated changes in animal models. We investigated the safety and efficacy of oral nicotinamide mononucleotide supplementation in older patients with diabetes and impaired physical performance.MethodWe carried out a 24‐week placebo‐controlled, double‐blinded study of male patients with diabetes aged ≥65 years with reduced grip strength (<26 kg) or walking speed (<1.0 m/s). The primary end‐points were to determine the safety of NMN oral administration (250 mg/day), and changes in grip strength and walking speed. The secondary end‐points were to determine the changes in various exploratory indicators.ResultsWe studied 14 participants aged 81.1 ± 6.4 years. NMN was tolerable without any severe adverse events. The changes in grip strength and walking speed showed no difference between the two groups: 1.25 kg (95% confidence interval −2.31 to 4.81) and 0.033 m/s (−0.021 to 0.087) in the NMN group, and −0.44 kg (−4.15 to 3.26) and 0.014 m/s (−0.16 to −0.13) in the placebo group, respectively. There were no significant differences in any exploratory indicators between the two groups. However, improved prevalence of frailty in the NMN group (P = 0.066) and different changes in central retinal thickness between the two groups (P = 0.051) was observed.ConclusionIn older male patients with diabetes and impaired physical performance, NMN supplementation for 24 weeks was safe, but did not improve grip strength and walking speed. Geriatr Gerontol Int 2023; 23: 38–43.
Area under the curve: Comparing the value of factor VIII replacement therapies in haemophilia A
Authors: Persson Sofie , Berndt Cecilia , Engstrand Sara , Trinczek Annegret , Carlsson Katarina Steen , Berntorp Erik 
Published: November 2022

AbstractIntroductionIn factor VIII (FVIII) prophylaxis for haemophilia A, cost comparisons have used price per international unit (IU) based on the once reasonable assumption of equivalent outcome per IU. Now, with several extended half‐life (EHL) products available, new outcome‐oriented ways to compare products are needed. Area under the curve (AUC) quantifies FVIII levels over time after infusion providing comparable data.AimTo develop a decision analytical model for making indirect comparisons of FVIII replacement products based on AUC.MethodsA literature search identified 11 crossover studies with relevant pharmacokinetic data. A common comparator FVIII level curve was calculated using pooled data from selected studies. Absolute curves for other products were estimated based on relative differences to the common comparator (% difference vs the anchor). Three scenarios were investigated: (1) Kogenate® versus Kovaltry® and Jivi®; (2) Advate® versus Elocta®, NovoEight®, Kovaltry, Adynovate®, Afstyla®, and ReFacto®; and (3) Jivi versus Elocta, Adynovate, and Kogenate. Sensitivity analyses investigated effects of assay type and dose.ResultsIn scenario 1, Jivi (+50%) and Kovaltry (+14%) showed larger AUCs versus Kogenate. In scenario 2, EHL products, Elocta and Adynovate, had the largest AUC (+64% and +58%, respectively) versus Advate. Compared with all other products in scenario 3, Jivi had the largest AUC by +13%–28%.ConclusionThis analysis concludes that EHL products differ in relative AUC, have a larger AUC compared with standard half‐life, and thus, different FVIII levels over time after infusion. This model may aid decision makers in the absence of head‐to‐head data.
A social identity approach to COVID‐19 transmission in hospital settings
Authors: Hlubek Niklas , Templeton Anne , Wiseman‐Gregg Kirsty 
Published: November 2022

AbstractThe COVID‐19 pandemic poses a substantial risk of disease spread among healthcare workers (HCWs), making it important to understand what impacts perceived risk of COVID‐19 spread in hospital settings and what causes HCWs to mitigate COVID‐19 spread by following COVID‐19 safety measures. One determinant of risk perception and safe behaviors is the influence of seeing others as group members. The current study aims to (a) evaluate how social identification as an HCW and trust in co‐workers may influence perceived risk of COVID‐19 spread and (b) explore how communication transparency, trust in leaders, and identity leadership are associated with self‐reported adherence to COVID‐19 safety guidance. Using a correlational design, HCWs of a Scottish hospital were invited to participate in an online questionnaire measuring their perceptions of risk of COVID‐19 transmission, measures of social identification as an HCW, perception of leaders as members of the team, trust in co‐workers to follow the COVID‐19 guidelines and perception of leaders to manage COVID‐19 prevention effectively. Results showed that increased trust in co‐workers was associated with reduced risk perception of COVID‐19 transmission. Perceptions of transparent communication about COVID‐19 were found to be associated with increased adherence to COVID‐19 safety guidelines. Findings show the importance of the association between social identity processes and reduced risk perception and highlight the relationship between transparent communication strategies and self‐reported adherence to COVID‐19 guidelines, identity leadership, and trust in leaders to manage COVID‐19 appropriately.
A new Parakneria Poll 1965 (Gonorhynchiformes: Kneriidae), ‘Mikinkidi’ from the Upper Lufira Basin (Upper Congo: DRC): Evidence from a morphologic and DNA barcoding integrative approach
Authors: Kiwele Mutambala Pacifique , Abwe Emmanuel , Schedel Frederic D. B. , Chocha Manda Auguste , Schliewen Ulrich K. , Vreven Emmanuel J. W. M. N. 
Published: November 2022

AbstractA new species, Parakneria alytogrammus, is described from the main stream of the Upper Lufira River. This species is easily distinguished from its congeners from the Congo Basin by its unique colouration, consisting of a low number of transversal bands on each of the caudal‐fin lobes, 2 (vs. 3–5) and the presence of an uninterrupted lateral mid‐longitudinal black band in fresh and preserved specimens (vs. absent). In addition, the new species differs from its Upper Lualaba congeners by the narrow width of its pectoral‐fin base, 4.8–5.6% LS [vs. wider, 8.2–10.1% for P. lufirae, 8.6% LS for P. damasi (holotype), and 7.6–7.9% LS for P. thysi]. Finally, it differs from the only species currently known from the Luapula‐Mweru system, P. malaissei, by having a short post‐dorsal distance, 36.4–36.6% LS (vs. longer, 38.6–41.1% LS) and a short post‐pelvic distance of 40.0–40.6% LS (vs. longer, 41.4–44.1% LS). Mitochondrial DNA‐haplotypes of P. alytogrammus sp. nov. form a clade, which is sister to the P. thysi clade, and from which it diverges by a genetic (Kimura 2‐parameter and uncorrected p) distance of 0.7% in the COI‐barcoding locus. The Upper Lufira, one of the sub‐basins of the Upper Congo Basin, remains poorly explored relative to its fish fauna. In contrast, the region is well explored with regard to its mineral wealth. Unfortunately, mining exploitation is carried out in the region without proper concern for the environment. Thus, the discovery of this new species for science calls for increased protection and aquatic biodiversity exploration in this mining region.