bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation study of NF-κB, IER3, and recurrence of ovarian endometrioid cysts
Authors: Yang Ni , Huang Gu , Fan Xiang , Zhang Chao , Wang Li , Jiang Xian , Fan Gang , Zhang Lina , Zhu Pengfeng 
Published: November 2022

Abstract
Objective
To investigate the expression of nuclear actor-k-gene binding(NF-κB) and immediate early response 3(IER3) in nuclear factor-activated B cells in ovarian endometrioid cysts. To analyze the correlation between the expression of NF-κB and IER3 and the recurrence of the ovarian endometrioid cyst.
Methods
From January 2018 to March 2019, a total of 80 patients who underwent laparoscopic ovarian cyst excision due to ovarian endometrioid cyst in the Department of Gynecology, Changzhou Maternal and Child Health Hospital were selected, including 40 patients without postoperative recurrence and 40 patients with recurrence, and the patients with recurrence were further divided into the primary recurrence and the secondary recurrence groups. The general clinical data of the patients were collected. The patient's Revised American Fertility Society (R-AFS) score, least function(LF) score, and endometriosis fertility index (EFI) were calculated, and immunohistochemical staining was performed to detect the expression of IER3 and NF-κB in the pathological tissues of the three groups. The receiver operating characteristic (ROC) curve was used to evaluate the predictive value of IER3 and NF-κB expression on postoperative recurrence of the ovarian endometrioid cyst. Cox proportional hazards model was fitted to analyze the related influencing factors of ovarian endometrioid cyst recurrence.
Results
The expression intensity of NF-κB was positively correlated with IER3 (P < 0.001). ROC curve showed that the area under curve (AUC) of NF-κB and IER3 combined diagnosis was 0.844, 95%CI was 0.754–0.933, sensitivity was 77.5% and specificity was 90.00%. Multivariate Cox survival regression showed that the IER3 expression intensity > 4.5 (HR = 4.661,95%CI: 1.712–12.690, P = 0.003) and the NF-κBexpression intensity > 4.5 (HR = 2.878,95%CI: 1.181–7.011, P = 0.020) were independent risk factor for postoperative recurrence, and EFI score (HR = 1.289,95%CI: 1.037–1.602, P = 0.022) was a protective factor for postoperative recurrence.
Conclusion
EFI score is a protective factor for postoperative recurrence, and the expression intensity of NF-κB and IER3 has a certain correlation with the recurrence of ovarian endometrioid cysts. The expression levels of NF-κB and IER3 > 4.5 are independent risk factors for postoperative recurrence.
A high performance dopingless Tunnel FET with pocketed architecture: proposal and analysis
Authors: Haneef Nazia , Raushan Mohd Adil , Bashir Md. Yasir , Siddiqui Mohammad Jawaid 
Published: November 2022

Abstract
In this paper, we have proposed the doping less dual material double gate Tunnel field-effect transistor with a P+ pocket (PP- DMG TFET). This gate engineered technique is ordinarily used in a MOSFET for performance augmentation. The P+ pocket is embedded at the source side to enhance the performance of pocket engineered PP- DMG TFET device. This paper compares the performance of four DG-TFET based devices i.e. single material gate TFET (SMG), single material gate with P+ pocket TFET (PP-SMG), dual material gate TFET (DMG DG), dual material gate with P+ pocket (PP-DMG). Electrostatic doping based on charge plasma notion forms the requisite structure n-i-p + for tunneling formed on a thin intrinsic silicon layer. The proposed device (PP-DMG) has a high on-current capability, high ON/OFF ratio and lower point subthreshold of 15.3 mV/dec, and an average subthreshold of 18.6 mV/dec. The analog parameters evaluated include transconductance (gm) and cutoff frequency (fT) have shown impressive improvement. We have also discussed the device efficiency and transconductance frequency product (TFP) finally we have done the linearity and distortion analysis on parameters such as VIP2, VIP3, IIP3, and IMD3 analysis.
Matrix metalloproteinase-8 level in the peri-implant sulcular fluid around dental implant abutments with different geometries and manufacturing strategies: A randomized controlled trial
Authors: Raheem Islam M. Abdel , Hammad Ihab A. , Kader Sanaa H. Abdel , Hadidi Abeer S. El , Fahmy Rania A. 
Published: November 2022

Abstract
Background. The purpose of this clinical trial was to assess soft tissue reaction around custom dental implant abutments by evaluation of Matrix Metalloproteinase-8 (MMP-8) level in peri-implant sulcular fluid (PISF) and clinical parameters.
Methods. Thirty participants with missing mandibular first molar were enrolled in this randomized controlled trial. Each participant underwent implant placement following the standard 2-stage surgical protocol. All participants were randomly allocated to one of the two groups; Control Group (n=15): Pre-machined stock titanium abutment, and Study Group (n=15): Custom titanium CAD-CAM abutment. Combined screw- and cement-retained zirconia crowns were used to restore implants. The PISF samples were collected at 1, 3, 6 and 12 months after placement of restorations. MMP-8 level was assessed by Enzyme-Linked ImmunoSorbent Assay. Peri-implant probing depth (PPD), simplified mucosal index (SMI) and modified plaque index (mPI) scores were assessed at all time-points. Crestal bone loss (CBL) was assessed by using bitewing radiographs made at baseline and 12-month time points. Two-way repeated-measures ANOVA and Friedman test were used to analyze data.
Results. There was a significant effect of the interaction of time and abutment type where the change in MMP-8 and PPD in CA was higher than in SA. SMI, mPI and CBL recorded no statistical differences between the two groups after one year (P > 0.05).
Conclusions. The change in the level of MMP-8 and in PPD after one year is significantly higher in custom abutments. However, this change was of low clinical impact.
Trial Registery: the trial was registered in the Pan African Clinical Trial Registry under identification number PACTR201809736563842 (25/ 09/ 2018)
Groundwater provides temporary resilience to alpine catchments in glacial retreat
Authors: Miller Jordyn , Frisbee Marty , Hamilton Trinity , Liljedahl Anna 
Published: November 2022

Abstract
Surface runoff from melting alpine glaciers increases until the glaciers reach a condition called “peak water” beyond which surface runoff decreases as ice volume diminishes. Recent research indicates that a fraction of this meltwater recharges mountain-block aquifers thereby providing vital support to baseflow in alpine streams and perennial flow from alpine springs. However, the response of baseflow to deglaciation has not been thoroughly quantified. Combining statistical timeseries analysis of discharge data with the delayed flow index (DFI), we show that the proportion of baseflow in post-peak water discharge has increased compared to pre-peak discharge in three glacial catchments in the Swiss Alps. The timing of peak water is not concurrent with the baseflow response. The increase in baseflow is sustained for 20 to 40 years after the occurrence of peak water; however, this is a transient response. In fact, one catchment has lost baseflow support and is now responsive to seasonal precipitation events. Given the slower response times of groundwater, baseflow will eventually decrease in these catchments making them more responsive to precipitation events and less resilient to fluctuations in precipitation once the ice is gone. These conditions will have severe impacts to alpine streams and springs and their ecosystems.
Inequalities in local government spending on Cultural, Environmental and Planning services: a time-trend analysis in England, Scotland, and Wales
Authors: Fahy Katie , Alexiou Alexandros , Mason Kate , Bennett Davara , Egan Matt , Taylor-Robinson David , Barr Ben 
Published: November 2022

Abstract
Background

Local government provides Cultural, Environmental, and Planning (CEP) services, such as parks, libraries, and waste collection, that are vital for promoting health and wellbeing. There have been significant changes to the funding of these services over the past decade, most notably due to the UK government’s austerity programme. These changes have not affected all places equally. To understand potential impacts on health inequalities, we investigated geographical patterning of recent CEP spending trends.

Methods

We conducted a time trend analysis using routinely available data on local government expenditure. We used generalised estimating equations to determine how expenditure trends varied across 378 local authorities (LAs) in Great Britain between 2009/10 and 2018/19 on the basis of country, deprivation, rurality, and local government structure. We investigated the gross expenditure per capita on CEP services, and the CEP expenditure as a proportion of total local authority budgets.

Results

Expenditure per capita for CEP services reduced by 36% between 2009/10 and 2018/19. In England, the reduction in per capita spending was steepest in the most deprived quintile of areas, falling by 7.5% [95% CI: 6.0, 8.9] per year, compared to 4.5% [95% CI: 3.3, 5.6] in the least deprived quintile. Budget cuts in Scotland and Wales have been more equitable, with similar trends in the most and least deprived areas. Welsh LAs have reduced the proportion of total LA budget spent on CEP services the most (-4.0% per year, 95% CI: -5.0 to -2.9), followed by Scotland (-3.0%, 95% CI: -4.2 to -1.7) then England (-1.4%, 95% CI: -2.2 to -0.6). In England, rural and unitary LAs reduced their share of spending allocated to CEP more than urban and two-tier structured LAs, respectively.

Conclusion

Funding for cultural, environmental and planning services provided by local government in the UK has been cut dramatically over the last decade, with clear geographical inequalities. Local areas worst affected have been those with a higher baseline level of deprivation, those with a single-tier local government structure, and English rural local authorities. The inequalities in cuts to these services risk widening geographical inequalities in health and wellbeing.
Assessing the Effect of Age at Sexual Debut on HIV Acquisition among Adolescents Girls and Young Women in Malawi: Evidence from Malawi Population-based HIV Impact Assessment
Authors: Moyo Reuben Christopher , Nyasulu Peter Suwilakwenda , Govindasamy Darshini 
Published: November 2022

Abstract
Background: Adolescent girls and young women (AGYW) constitute the highest proportion of all new HIV infections in sub-Saharan Africa (SSA). Age at sexual debut is one of the sexual behavior factors that predict HIV in AGYW. This study aimed at assessing the effect of age at sexual debut on HIV acquisition among AGYW in Malawi using the 2016 Malawi Population-based HIV Impact Assessment (MPHIA).
Methods: We analyzed HIV related data on 1,921 AGYW from the 2015/16 MPHIA. Associations between HIV infection and predictor variables were assessed using both univariate and multivariate logistic regression. The effect of age at sexual debut on HIV acquisition was assessed using binary logistic regression model.
Results: The weighted HIV prevalence among AGYW was 4.7%. The prevalence was high for AGYW from southern region (7.8%) compared to the central (2.3%) and the northern region (2.1%). AGYW from urban areas had more than twice the prevalence compared to those from rural areas (9.1% versus 3.7% for urban and rural areas respectively). This study has identified 9 behavioral and contextual factors that are associated with HIV infection among AGYW, and these are: Region (p<0.001), Residence (p<0.001), Age (p=0.008), Age at first sex (p=0.001), Age at marriage (p0.0131), Marital status (p<0.001), Education (p=0.002), Wealth quintile (p=0.05) and Partner at last sex (p<0.001). AGYW who started sex before the age of 15 were more than two times more likely (OR 2.47, 95% CI 1.52 – 4.05) to test HIV positive compared to those who started after the age of 15.
Conclusion: We conclude that early sexual debut occurring before the age of 15, significantly predict HIV among AGYW in Malawi. To reduce their risk to acquiring HIV, such AGYW should be linked to HIV preventions services such to HIV pre-exposure prophylaxis services in order to minimize their risk of HIV transmission.
Risk Factors of Blood Transfusion During Cesarean Section
Authors: Hu Peilu , Zhang Xiaohui 
Published: November 2022

Abstract
Backgroud: this work was to explore the risk factors of postpartum hemorrhage among puerperae in XX Hospital, and to analyze the influence of high risk factors of postpartum hemorrhage.
Methods: the electronic medical record system was adopted to include 220 cases, and 78 puerperae were screened into the blood transfusion group. The clinical indicators of puerperae were analyzed, and the preoperative liver function and renal function were analyzed. The indexes of blood coagulation status and blood routine indexes of puerperae after blood transfusion before blood transfusion were analyzed. Risk factors for blood transfusion during cesarean section were analyzed using a machine learning model.
Results: prenatal examination and diagnosis showed that the abnormal placenta accounted for 28.21%; the abnormal amniotic fluid accounted for 7.69%; the umbilical cord around neck accounted for 21.79%; threatened premature birth accounted for 24.36%; scarred uterus accounted for 24.36%; preeclampsia accounted for 20.52%; and anemia accounted for 30.77%. The mean prenatal ALT of liver function index was 20.21, the mean value of AST was 21.29. The mean value of blood urea of renal function index was 4.59, and the mean value of serum creatinine was 46.27. The indexes of blood coagulation status after blood transfusion, RBC, Hct, Plt, PT, APTT, Fbg, and D-D, were significantly different from those before blood transfusion (P < 0.05). The blood routine before blood transfusion indicated that Hb, RBC, and Hct were significantly different from those after blood transfusion (P < 0.05).
Conclusion: risk factors of blood transfusion during cesarean section included placenta accreta, placental abruption, placental adhesion, polyhydramnios, pregnancy-induced hypertension, uterine atony, uterine fibroids, cesarean section, and dangerous placenta previa. Risk factors for blood transfusion during cesarean section may gradually decrease with increasing gestational age.
Regulatory aspects of a nanomaterial for imaging therapeutic cells
Authors: Zee Margriet van der , de Vries Claudette , Masa Marc , Morales Marta , Rayo Marta , Hegger Ingrid 
Published: November 2022

Abstract
The ability to track therapeutic cells upon administration to the patient is of interest to both regulators and developers of cell therapy. The European Commission Horizon2020 project nTRACK from 2017-2022 aimed to develop a multi-modal nano-imaging agent to track therapeutic cells during development of a cell therapy. As part of this project, we investigated the regulatory pathway involved for such a product.
An important regulatory hurdle appeared to be the appropriate regulatory classification the nTRACK nano-imaging agent, as neither the definition for medicinal product nor the definition for medical device were a good fit for the purpose of the product. As a consequence, the information requirements to fulfill before conducting a First in Human trial are not evident and can only be decided upon by closely collaborating and communicating with the relevant authorities throughout the development of the product. Moreover, standard test methods for demonstrating the quality and safety of a medicinal product or medical device are not always suitable for nanomaterials such as the nTRACK nano-imaging agent. Regulatory agility is therefore a great need to prevent delay of promising medical innovations, although regulatory guidance on these products will likely improve with more experience.
In this article, we outline the lessons learnt related to the regulatory process of the nTRACK nano-imaging agent for tracking therapeutic cells and offer recommendations to both regulators and developers of similar products.
A System of Subsystems: Hierarchical Modularity of Guard Cell ABA Signalling Network defines its Evolutionary Success
Authors: samarasinghe sandhya , Waidyarathne Pramuditha 
Published: November 2022

Abstract
Biological functions are accomplished by extensive molecular signalling networks that are too complex to comprehend their meaning. This study aims to exploit computational network analysis on a model system to unravel network complexity to gain insights into the principles of organization of molecular networks. Plants respond to drought stress by stomatal closure, the most rapid physiological response in plant leaves where aperture between two guard cells closes rapidly to prevent water loss. ABA (Abscisic acid) signalling network that accomplishes stomatal closure in guard cells is thought to be an evolutionarily well conserved system organized to control the stomatal aperture in response to drought stress. However, functional organization and evolutionary success of this system is yet to be explored for gaining deeper insights into the operation and success of this system. This study views this signaling system from a holistic perspective and hypothesizes that it is an interconnected system of subsystems evolved to facilitate the communication flow of the whole system to respond to the signals by means of a collection of feedback processes with shifting dominance in time and space. Further, it is known that topological properties of biological networks can reveal the influence of structural properties on the functional and dynamical properties of a system. Therefore, this study exploits topology analysis of an updated ABA signalling network using graph theoretic measures involving topological dissimilarity based node clustering to explore its modularity to characterize it as a system of subsystems. The paper explains the hierarchical modules identified by topological distance measures and hub elements identified by centrality measures. Network was decomposed into three subsystems comprising seven functional modules along with a number of hub elements that provided an easy to understand view of ABA signaling. This system of subsystems view enabled by modularity revealed a meaningful and coherent organization of the structure and function of the complex ABA network. Further, ABA signaling network was found to be a scale-free network that defines its evolutionary success.
WGCNA Reveal Potential Diagnosis Biomarkers and Therapeutic Targets for COVID-19 Infection in Patients with Sepsis
Authors: Huang Chunsheng , Tong Qiaoling , Zhang Wenyuan , Chen Xiaofei , Pan Zhihao 
Published: November 2022

Abstract
Background
Sepsis patients have the worst outcomes when affected by coronavirus disease 2019 (COVID-19). Unknown are the molecular mechanisms underlying the relationship between sepsis and COVID-19. The primary purpose of the present work was to establish whether there is interaction between COVID-19 and sepsis in terms of molecular perturbation and to uncover a molecular signature, molecular networks, and signaling pathways shared by the two disorders.
Methods
We retrieved the sepsis and COVID-19 datasets from the Gene Expression Omnibus (GEO) database and used Weighted Gene Co-Expression Network Analysis (WGCNA) to identify key modules. On the common genes residing in the sepsis and COVID-19 associated modules, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted. Then, using the STRING database, we constructed the protein-protein interaction (PPI) network and identified its hub genes. Finally, The immune cell infiltration score and immune-associated pathway activity were calculated using single-sample gene set enrichment analysis (ssGSEA).
Results
Functional enrichment analysis indicated that antigen processing and presentation of peptide antigen via MHC class I, antigen processing and presentation of peptide antigen, antigen processing and presentation, T cell mediated cytotoxicity and T cell mediated immunity were probably involved in sepsis comorbided with COVID-19. Pathway enrichment analysis of the common genes of key modules identified the underlying biological processes in COVID-19-related sepsis, including Antigen processing and presentation, Phagosome, Natural killer cell mediated cytotoxicity and Adipocytokine signaling pathway. PPI network construction indicated that sepsis comorbided with COVID-19 is likely related to 5 hub genes, including B2M, TNFSF10, TLR3, JAK2, and IRF2. ssGSEA results illustrated that 5 hub genes are closely related to the immune status of sepsis.
Conclusions
In summary, our work indicated a total of 5 hub genes including B2M, TNFSF10, TLR3, JAK2, and IRF2, which especially underlie the comorbidity mechanisms of sepsis and COVID-19. These shared pathways may give new targets for mechanistic research into the development and management of sepsis and COVID-19.
Continent-scale mapping reveals a rise in East Antarctic surface meltwater
Authors: Tuckett Peter , Ely Jeremy , Sole Andrew , Livingstone Stephen , Jones Julie , Lea James , Gilbert Ella 
Published: November 2022

Abstract
The future sea-level contribution from the Antarctic ice sheets is highly uncertain. Ice dynamic, hydrofracture, and radiative processes related to surface meltwater are predicted to become increasingly important for Antarctic mass-loss as atmospheric temperatures rise. Our understanding of Antarctic surface meltwater, however, remains limited, with previous studies restricted in spatial or temporal scope. Here, we leverage cloud computing to overcome these limitations and produce the first Antarctic-wide, monthly dataset of surface meltwater spanning 2006 to 2021. Surface meltwater covered 3732 km2 across Antarctica on average during each melt season, with 30% on grounded ice. High interannual variability in meltwater coverage across the Antarctic Peninsula and in East Antarctica correlates with large-scale modes of climate variability, but this control is absent where meltwater coverage is comparatively low in West Antarctica. In East Antarctica, we find a significant increasing trend in meltwater area of 66 km2 per year (197% total change) which, in the absence of a clear climatic trend, we attribute to ice sheet surfaces becoming more favourable to ponding. Future increases in melt rate could therefore cause proportionally larger increases in meltwater coverage with implications for the resilience of ice shelves, and increased surface-to-bed hydraulic connections on grounded ice.