bluuebunny/crossref_metadata_2025_split huggingface dataset:
Classification of functional and non-functional arm use by inertial measurement units in individuals with upper limb impairment after stroke
Authors: Pohl Johannes , Ryser Alain , Veerbeek Janne Marieke , Verheyden Geert , Vogt Julia Elisabeth , Luft Andreas Rüdiger , Awai Easthope Chris 
Published: September 2022

Background:Arm use metrics derived from wrist-mounted movement sensors are widely used to quantify the upper limb performance in real-life conditions of individuals with stroke throughout motor recovery. The calculation of real-world use metrics, such as arm use duration and laterality preferences, relies on accurately identifying functional movements. Hence, classifying upper limb activity intofunctionalandnon-functionalclasses is paramount. Acceleration thresholds are conventionally used to distinguish these classes. However, these methods are challenged by the high inter and intra-individual variability of movement patterns. In this study, we developed and validated a machine learning classifier for this task and compared it to methods using conventional and optimal thresholds.Methods:Individuals after stroke were video-recorded in their home environment performing semi-naturalistic daily tasks while wearing wrist-mounted inertial measurement units. Data were labeled frame-by-frame following the Taxonomy of Functional Upper Limb Motion definitions, excluding whole-body movements, and sequenced into 1-s epochs. Actigraph counts were computed, and an optimal threshold for functional movement was determined by receiver operating characteristic curve analyses on group and individual levels. A logistic regression classifier was trained on the same labels using time and frequency domain features. Performance measures were compared between all classification methods.Results:Video data (6.5 h) of 14 individuals with mild-to-severe upper limb impairment were labeled. Optimal activity count thresholds were ≥20.1 for the affected side and ≥38.6 for the unaffected side and showed high predictive power with an area under the curve (95% CI) of 0.88 (0.87,0.89) and 0.86 (0.85, 0.87), respectively. A classification accuracy of around 80% was equivalent to the optimal threshold and machine learning methods and outperformed the conventional threshold by ∼10%. Optimal thresholds and machine learning methods showed superior specificity (75–82%) to conventional thresholds (58–66%) across unilateral and bilateral activities.Conclusion:This work compares the validity of methods classifying stroke survivors’ real-life arm activities measured by wrist-worn sensors excluding whole-body movements. The determined optimal thresholds and machine learning classifiers achieved an equivalent accuracy and higher specificity than conventional thresholds. Our open-sourced classifier or optimal thresholds should be used to specify the intensity and duration of arm use.
On the superiority of a combination of aerobic and resistance exercise for fibromyalgia syndrome: A network meta-analysis
Authors: Chen Jiping , Han Bing , Wu Chenggang 
Published: September 2022

BackgroundFibromyalgia syndrome is the second most common chronic diffuse pain disorder and can have a lasting negative impact on the quality of life, pain, and physical function of people. Exercise therapy is an important component of the treatment of fibromyalgia, but there was not a consensus understanding of the effect of various exercise programs on the quality of life, pain, and physical function of people with fibromyalgia syndrome. This study aimed to compare three exercise programs (aerobic exercise, resistance exercise, and a combination of aerobic and resistance exercise) in their effectiveness in improving quality of life, relieving muscle pain, and enhancing physical function in patients with fibromyalgia.MethodsA comprehensive search of databases, including China National Knowledge Internet, Wan fang, The Cochrane Library, PubMed, EMBASE, and Web of Science, was conducted to identify randomized controlled trials on exercise therapy for patients with fibromyalgia syndrome with outcome indicators including at least one of Fibromyalgia Impact Questionnaire (FIQ), Tender point count (TPC), and 6-minute walk test (6MWT) from the date of database creation on 20 April 2022. The included studies were evaluated for literature quality according to Cochrane Handbook criteria, and a network meta-analysis was performed using STATA 14.0.ResultForty-five randomized controlled trials met all inclusion criteria and were analyzed. The network meta-analysis showed that a combination of aerobic and resistance exercise was ranked first in all three dimensions of quality of life improvement, pain alleviation, and physical function enhancement (Mean Rank = 1.6, 1.2, 5.9).ConclusionThe current meta-analysis demonstrates that the combination of aerobic and resistance exercise may be the best type of exercise to accentuate the quality of life, pain alleviation, and physical function for people with fibromyalgia syndrome.
Validation of the Chinese version of the Somatic Symptom Scale-8 in patients from tertiary hospitals in China
Authors: Li Tao , Wei Jing , Fritzsche Kurt , Toussaint Anne C. , Zhang Lan , Zhang Yaoyin , Chen Hua , Wu Heng , Ma Xiquan , Li Wentian , Ren Jie , Lu Wei , Leonhart Rainer 
Published: September 2022

ObjectiveTo validate the Chinese language version of the Somatic Symptom Scale-8 (SSS-8) in a sample of outpatients attending tertiary hospitals in China.Materials and methodsA Chinese language version of the SSS-8 was completed by outpatients (n = 699) from psychosomatic medicine, gastroenterology/neurology, and traditional Chinese medicine clinics of nine tertiary hospitals between September 2016 and January 2018 to test the reliability. The Patient Health Questionnaire-15 (PHQ-15), the Somatic Symptom Disorder–B Criteria Scale (SSD-12), the Patient Health Questionnaire-9 (PHQ-9), the General Anxiety Disorder-7 (GAD-7) scale, the Medical Outcome Study 12-item Short Form Health Survey (SF-12) and the World Health Organization Disability Assessment Schedule (WHO DAS 2.0) were rated to test construct validity. The criterion validity was tested by using the Semi-structured Clinical Interview for DSM-5 (Research Version) (SCID-5-RV) for somatic symptom disorder (SSD) as the diagnostic gold standard to explore the optimal cutoff score of the SSS-8.ResultsThe average age of the recruited participants was 43.08 (±14.47). 61.4% of them were female. The internal consistency derived from the sample was acceptable (Cronbach α = 0.78). Confirmatory factor analyses resulted in the replication of a three-factor model (cardiopulmonary symptoms, pain symptoms, gastrointestinal and fatigue symptoms) (comparative fit index = 0.95, Tucker-Lewis index = 0.92, root mean square error of approximation = 0.10, 90% confidence interval = 0.08–0.12). The SSS-8 sum score was highly associated with PHQ-15 (r = 0.74, p &lt; 0.001), SSD-12 (r = 0.64, p &lt; 0.001), GAD-7 (r = 0.59, p &lt; 0.001), and PHQ-9 (r = 0.69, p &lt; 0.001). The patients with more severe symptoms showed worse quality of life and disability The optimal cutoff score of SSS-8 was 9 (sensitivity = 0.67, specificity = 0.68).ConclusionOur preliminary assessment suggests that the Chinese language version of the SSS-8 has reliability and validity sufficient to warrant testing further in research and clinical settings.
Effect of occupational exposure to welding fumes and noise on heart rate variability: An exposed-unexposed study on welders and airport workers' population
Authors: Lucas David , Guerrero François , Jouve Emmanuel , Hery Sophie , Capellmann Pascale , Mansourati Jacques 
Published: September 2022

IntroductionWelding fumes (WF) are a complex mixture of gas and particles. Action of occupational exposure to WF on cardiovascular system has been recently studied as for noise.Research questionThe main objectives of our study are therefore to evaluate the impact of exposure to WF, noise, and combined WF and noise on autonomic nervous system as assessed by heart rate variability (HRV).MethodsThe study groups were 16 welders and eight airport workers (as a control group). All the participants underwent ambulatory electrocardiogram, personal WF, and noise exposure monitoring, respectively, with dust track and calibrated noise dosimeter during workday. Atmospheric environmental assessments at workplaces have been also performed. HRV parameters were summarized for all the workday and hourly. Correlation tests were used to examine relation between HRV parameters and levels of noise exposure in the two population. Analysis of covariance (ANCOVA) was used for mean of each HRV parameters.ResultsFor HRV parameters, we found significant higher levels for mean range of high frequency (HF), standard deviation of normal-to-normal R-R interval (SDNN), and root mean square of successive heartbeat interval difference (RMSSD) in welders which suggested an imbalance between sympathetic and parasympathetic nervous system in this population. For relation between noise and HRV parameters, we noted that levels of low frequency (LF), HF, and SDNN were significantly correlated with mean noise levels for welders (respectively, r = 0.62, r = 0.357, r = 0.48), not in control group. Using ANCOVA, we found that working as a welder significantly increases mean of HF (p = 0.01) and RMSSD (p = 0.02) and decreases in LF/HF (p = 0.008). Indeed, the interaction between exposure to WF and mean noise levels for HF (p = 0.005), LF/HF (p = 0.01), and RMSSD (p = 0.007) was significant.ConclusionThis study shows an impact of WF and noise on ANS balance. One hypothesis is WF exposure could increase sensibility to noise exposure on autonomic nervous system or there is a synergic effect.
The association of dietary spermidine with all-cause mortality and CVD mortality: The U.S. National Health and Nutrition Examination Survey, 2003 to 2014
Authors: Wu Huanyu , Wang Jianing , Jiang Hongyan , Liu Xin , Sun Xinyi , Chen Yunyan , Hu Cong , Wang Zheng , Han Tianshu , Sun Changhao , Wei Wei , Jiang Wenbo 
Published: September 2022

BackgroundCurrent studies on the protective effects of dietary spermidine (SPD) on cardiovascular disease (CVD) are mainly limited to animal studies, and the relationship between dietary SPD and CVD mortality remains inconclusive.ObjectiveThis study aims to evaluate the association between dietary SPD intake and CVD and all-cause mortality.MethodsA total of 23,894 people enrolled in the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2014 were recruited for this study. The dietary intake of SPD from 11 specific food origins and total SPD was categorized into tertiles or quartiles. Cox proportional hazard regression models were developed to evaluate the association of SPD intake with CVD and all-cause mortalities.ResultsAmong the 23,894 participants, 2,365 deaths, including 736 deaths due to CVD, were documented. After adjustment for potential confounders, compared with participants in the lowest quartile, participants in the highest quartile of total SPD had a significantly lower risk of CVD mortality (HR = 0.68, 95% CI: 0.51–0.91) and all-cause mortality (HR = 0.70, 95% CI: 0.60–0.82); participants in the highest tertiles or quartiles of vegetable-derived SPD, cereal-derived SPD, legume-derived SPD, nut-derived SPD, and cheese-derived SPD had a lower risk of CVD mortality (HR vegetable − derivedSPD = 0.68, 95% CI: 0.54–0.86; HR cereal − derivedSPD = 0.75, 95% CI: 0.57–0.97; HR legume − derivedSPD = 0.68, 95% CI: 0.52–0.88; HR nut − derivedSPD = 0.66, 95% CI: 0.53–0.80; HR cheese − derivedSPD = 0.68, 95% CI: 0.52–0.88) and all-cause mortality (HR vegetable − derivedSPD = 0.73, 95% CI: 0.64–0.84; HR cereal − derivedSPD = 0.80, 95% CI: 0.69–0.93; HR legume − derivedSPD = 0.70, 95% CI: 0.60–0.80;HR nut − derivedSPD = 0.72, 95% CI: 0.64–0.81; HR cheese − derivedSPD = 0.70, 95% CI: 0.61–0.81) than those in the lowest tertiles or quartiles. Moreover, subgroup analysis showed consistent associations among the people with hypertension and hyperlipidemia.ConclusionHigher intake of dietary SPD is associated with decreased risk of CVD and all-cause mortality, and among specific food origin SPD, SPD derived from vegetables, cereals, legumes, nuts, and cheese was associated with reduced CVD and all-cause mortality.
Design and validation of a medical robotic device system to control two collaborative robots for ultrasound-guided needle insertions
Authors: Berger Johann , Unger Michael , Keller Johannes , Reich C. Martin , Neumuth Thomas , Melzer Andreas 
Published: September 2022

The percutaneous biopsy is a critical intervention for diagnosis and staging in cancer therapy. Robotic systems can improve the efficiency and outcome of such procedures while alleviating stress for physicians and patients. However, the high complexity of operation and the limited possibilities for robotic integration in the operating room (OR) decrease user acceptance and the number of deployed robots. Collaborative systems and standardized device communication may provide approaches to overcome named problems. Derived from the IEEE 11073 SDC standard terminology of medical device systems, we designed and validated a medical robotic device system (MERODES) to access and control a collaborative setup of two KUKA robots for ultrasound-guided needle insertions. The system is based on a novel standard for service-oriented device connectivity and utilizes collaborative principles to enhance user experience. Implementing separated workflow applications allows for a flexible system setup and configuration. The system was validated in three separate test scenarios to measure accuracies for 1) co-registration, 2) needle target planning in a water bath and 3) in an abdominal phantom. The co-registration accuracy averaged 0.94 ± 0.42 mm. The positioning errors ranged from 0.86 ± 0.42 to 1.19 ± 0.70 mm in the water bath setup and from 1.69 ± 0.92 to 1.96 ± 0.86 mm in the phantom. The presented results serve as a proof-of-concept and add to the current state of the art to alleviate system deployment and fast configuration for percutaneous robotic interventions.
Treatment of unruptured middle cerebral artery aneurysms: Systematic review in an attempt to perform a network meta-analysis
Authors: Arrese Ignacio , García-García Sergio , Cepeda Santiago , Sarabia Rosario 
Published: September 2022

ObjectiveOpen surgical clipping has been generally considered the best treatment option for unruptured middle cerebral artery aneurysms (uMCAAs). However, this type of aneurysm is being treated endovascularly with the appearance of new devices. We have carried out a systematic review of randomized and quasi-experimental studies to conduct a network meta-analysis (NMA) to assess the safety and efficacy of the different treatment methods currently used in uMCAAs.MethodsThe literature was searched by using PubMed and Google Scholar databases. Eligibility criteria were randomized or quasi-experimental studies including at least five cases per arm and reporting duration of follow-up and number of lost cases. The end points were: angiographic success, final neurological outcome, and the need for retreatments.ResultsWe could only analyze four quasi-experimental studies with 398 uMCAAs. All of them compared clipping vs. coiling. Clipping showed better results than coiling in all analyzed end points. We could not conduct the proposed NMA because of the absence of randomized or quasi-experimental studies. Instead, a systematic review is further discussed.ConclusionsThere is an urgent need for comparative studies on the treatment of uMCAAs.
Pre-Orogenic Tectonostratigraphic Evolution of the European Distal Margin-Alpine Tethys Transition Zone in High-Pressure Units of the Southwestern Alps
Authors: Balestro Gianni , Festa Andrea , Cadoppi Paola , Groppo Chiara , Roà Matthieu 
Published: September 2022

Geological mapping, stratigraphic observations, and U/Pb dating allow reconstructing the pre-orogenic setting of the transition zone between the distal European passive margin and the Alpine Tethys in the southwestern Alps. Although convergent tectonics overprinted the syn-rift Jurassic tectonic features, our data document an articulated Jurassic physiography. From the distal European passive margin oceanward, we distinguished: the Dronero Unit (the southernmost Dora Maira massif), represents a continental margin composite basement wherein monometamorphic metasediments are interlayered with Late Permian (253.8 ± 2.7 Ma) metavolcanic rocks; the Sampeyre Unit, represents a structural high consisting of Lower Triassic Verrucano-facies siliciclastic metasediments unconformably sealed by Cretaceous calcschist bearing Globotruncana sp.; the Maira Unit, corresponds to a Middle Triassic platform succession detached from the Sampeyre Unit; the Grana Unit, corresponds to a Late Triassic–Late Jurassic platform to basin succession; the Queyras Schistes Lustrès Complex, represents the ocean basin succession. Tectonic slices of Cambrian (513.9 ± 2.7 Ma) metadiorite hosted in the Valmala Shear Zone, separating the Dronero Unit from the underlying (U)HP units of the Dora Maira massif, suggests a potential pre-Alpine activation of the shear zone.
Evaluating the Safety and Quality of Life of Colorectal Cancer Patients Treated by Autologous Immune Enhancement Therapy (AIET) in Vinmec International Hospitals
Authors: Nguyen Hoang-Phuong , Pham Duc-Anh Dao , Dinh Nguyen Duy , Nguyen Phong Van , Bui Viet-Anh , Hoang My-Nhung Thi , Nguyen Liem Thanh 
Published: September 2022

(1) Colorectal cancer (CRC) is an increasingly prevalent disease with a high mortality rate in recent years. Immune cell-based therapies have received massive attention among scientists, as they have been proven effective as low-toxicity treatments. This study evaluated the safety and effectiveness of autologous immune enhancement therapy (AIET) for CRC. (2) An open-label, single-group study, including twelve patients diagnosed with stages III and IV CRC, was conducted from January 2016 to December 2021. Twelve CRC patients received one to seven infusions of natural killer (NK)-cell and cytotoxic T-lymphocyte (CTL). Multivariate modelling was used to identify factors associated with health-related quality-of-life (HRQoL) scores. (3) After 20–21 days of culture, the NK cells increased 3535-fold, accounting for 85% of the cultured cell population. Likewise, CTLs accounted for 62.4% of the cultured cell population, which was a 1220-fold increase. Furthermore, the QoL improved with increased EORTC QLQ-C30 scores, decreased symptom severity, and reduced impairment in daily living caused by these symptoms (MDASI-GI report). Finally, a 14.3 ± 14.1-month increase in mean survival time was observed at study completion. (4) AIET demonstrated safety and improved survival time and HRQoL for CRC patients in Vietnam.
Anti-Forcing Spectra of Convex Hexagonal Systems
Authors: Zhang Yaxian , Zhang Bo , Zhang Heping 
Published: September 2022

For any perfect matching M of a graph AG, the anti-forcing number of M af(G,M) is the cardinality of a minimum edge subset S⊆E(G)\M such that the graph G−S has only one perfect matching. The anti-forcing numbers of all perfect matchings of G form its anti-forcing spectrum, denoted by Specaf(G). For a convex hexagonal system O(n1,n2,n3) with n1≤n2≤n3, denoted by H, it has the minimum anti-forcing number n1. In this paper, we derive a formula for its maximum anti-forcing number Af(H), i.e., the Fries number. Next, we prove that [n1,c]∪{c+2,c+4,…,Af(H)−2,Af(H)}⊆Specaf(H) for the specific integer c with the same parity as Af(H). In particular, we obtain that if n1+n2−n3≤1, then c=Af(H), which implies that Specaf(H)=[n1,Af(H)] is an integer interval. Finally, we also give some non-continuous situations: Specaf(O(2,n,n))=[2,4n−2]\{4n−3} for n≥2; the anti-forcing spectrum of H has a gap Af(H)−1 for n1=n2≥2 and n3 even, or n2=n3 and n1≥2 even.
Rest-frame Near-infrared Sizes of Galaxies at Cosmic Noon: Objects in JWST's Mirror Are Smaller than They Appeared
Authors: Suess Katherine A. , Bezanson Rachel , Nelson Erica J. , Setton David J. , Price Sedona H. , Dokkum Pieter van , Brammer Gabriel , Labbé Ivo , Leja Joel , Miller Tim B. , Robertson Brant , Wel Arjen van der , Weaver John R. , Whitaker Katherine E. 
Published: September 2022

Abstract
Galaxy sizes and their evolution over cosmic time have been studied for decades and serve as key tests of galaxy formation models. However, at z ≳ 1 these studies have been limited by a lack of deep, high-resolution rest-frame infrared imaging that accurately traces stellar mass distributions. Here, we leverage the new capabilities of the James Webb Space Telescope (JWST) to measure the 4.4 μm sizes of ∼1000 galaxies with

log

M

*

/

M

⊙

≥
9

and 1.0 ≤ z ≤ 2.5 from public CEERS imaging in the Extended Groth Strip deep field. We compare the sizes of galaxies measured from NIRCam imaging at 4.4 μm (λ
rest ∼ 1.6 μm) with sizes measured at 1.5 μm (λ
rest ∼ 5500 Å). We find that, on average, galaxy half-light radii are ∼9% smaller at 4.4 μm than 1.5 μm in this sample. This size difference is markedly stronger at higher stellar masses and redder rest-frame V − J colors: galaxies with M
* ∼ 1011
M
⊙ have 4.4 μm sizes that are ∼30% smaller than their 1.5 μm sizes. Our results indicate that galaxy mass profiles are significantly more compact than their rest-frame optical light profiles at cosmic noon, and demonstrate that spatial variations in age and attenuation are important, particularly for massive galaxies. The trend we find here impacts our understanding of the size growth and evolution of galaxies, and suggests that previous studies based on rest-frame optical light may not have captured the mass-weighted structural evolution of galaxies. This paper represents a first step toward a new understanding of the morphologies of early massive galaxies enabled by JWST’s infrared window into the distant universe.
The Behavior of HgMn Stars in the Far UV -Paper 14: HD 179761
Authors: Monier Richard 
Published: September 2022

Abstract
The analysis of low and high resolution spectra of the late B-type star HD 179761 recorded by the SWP camera on board the International Ultraviolet Explorer reveals no variations of the far ultraviolet flux of this star in 1983 May and June. The far ultraviolet resonance lines of Si ii are strong absorbers in the spectrum of HD 179761. The resonance lines of Ga ii, Ga iii and Hg ii, characteristic of clasical HgMn stars, do not seem to be present in the mean SWP spectrum of HD 179761. The currently available TESS lightcurves of HD 179761 suffer from data dropouts and suggest low amplitude variations with periods runing from 4.86 to 5.44 days which need confirmation.
Additions to Neopestalotiopsis (Amphisphaeriales, Sporocadaceae) fungi: two new species and one new host record from China
Authors: He Yu-Ke , Yang Qi , Sun Ya-Ru , Zeng Xiang-Yu , Jayawardena Ruvishika , Hyde Kevin , Wang Yong 
Published: September 2022

In this study, three Neopestalotiopsis taxa were identified, associated with leaves of Zingiber officinale, Elaeagnus pungens and Salacca zalacca.
Based on morphology and multi–gene analyses of the internal transcribed spacer (ITS), beta-tubulin (TUB2) and translation elongation factor 1–alpha (TEF1), the five strains of Neopestalotiopsis represent two novel and one known species. They are introduced with descriptions, illustrations and notes herein.