bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal selective floor cleaning using deep learning algorithms and reconfigurable robot hTetro
Authors: Ramalingam Balakrishnan , Le Anh Vu , Lin Zhiping , Weng Zhenyu , Mohan Rajesh Elara , Pookkuttath Sathian 
Published: September 2022

AbstractFloor cleaning robots are widely used in public places like food courts, hospitals, and malls to perform frequent cleaning tasks. However, frequent cleaning tasks adversely impact the robot’s performance and utilize more cleaning accessories (such as brush, scrubber, and mopping pad). This work proposes a novel selective area cleaning/spot cleaning framework for indoor floor cleaning robots using RGB-D vision sensor-based Closed Circuit Television (CCTV) network, deep learning algorithms, and an optimal complete waypoints path planning method. In this scheme, the robot will clean only dirty areas instead of the whole region. The selective area cleaning/spot cleaning region is identified based on the combination of two strategies: tracing the human traffic patterns and detecting stains and trash on the floor. Here, a deep Simple Online and Real-time Tracking (SORT) human tracking algorithm was used to trace the high human traffic region and Single Shot Detector (SSD) MobileNet object detection framework for detecting the dirty region. Further, optimal shortest waypoint coverage path planning using evolutionary-based optimization was incorporated to traverse the robot efficiently to the designated selective area cleaning/spot cleaning regions. The experimental results show that the SSD MobileNet algorithm scored 90% accuracy for stain and trash detection on the floor. Further, compared to conventional methods, the evolutionary-based optimization path planning scheme reduces 15% percent of navigation time and 10% percent of energy consumption.
Correlation between COVID-19 severity and previous exposure of patients to Borrelia spp.
Authors: Szewczyk-Dąbrowska Alina , Budziar Wiktoria , Harhala Marek , Baniecki Krzysztof , Pikies Aleksandra , Jędruchniewicz Natalia , Kaźmierczak Zuzanna , Gembara Katarzyna , Klimek Tomasz , Witkiewicz Wojciech , Nahorecki Artur , Barczyk Kamil , Kłak Marlena , Grata-Borkowska Urszula , Dąbrowska Krystyna 
Published: September 2022

AbstractPredictors for the risk of severe COVID-19 are crucial for patient care and control of the disease. Other infectious diseases as potential comorbidities in SARS-CoV-2 infection are still poorly understood. Here we identify association between the course of COVID-19 and Lyme disease (borreliosis), caused by Borrelia burgdorferi transmitted to humans by ticks. Exposure to Borrelia was identified by multi-antigenic (19 antigens) serological testing of patients: severe COVID-19 (hospitalized), asymptomatic to mild COVID-19 (home treated or not aware of being infected), and not infected with SARS-CoV-2. Increased levels of Borrelia-specific IgGs strongly correlated with COVID-19 severity and risk of hospitalization. This suggests that a history of tick bites and related infections may contribute to the risks in COVID-19. Though mechanisms of this link is not clear yet, screening for antibodies targeting Borrelia may help accurately assess the odds of hospitalization for SARS-CoV-2 infected patients, supporting efforts for efficient control of COVID-19.
Mannan-binding lectin serine protease-2 (MASP-2) in human kidney and its relevance for proteolytic activation of the epithelial sodium channel
Authors: Zachar Rikke , Thiel Steffen , Hansen Søren , Henriksen Maiken Lumby , Skjoedt Mikkel-Ole , Skjodt Karsten , Hamzaei Zohra , Madsen Kirsten , Lund Lars , Hummler Edith , Svenningsen Per , Jensen Boye Lagerbon 
Published: September 2022

AbstractProteolytic activation of the renal epithelial sodium channel (ENaC) is increased by aldosterone. The aldosterone-sensitive protease remains unidentified. In humans, elevated circulating aldosterone is associated with increased urinary extracellular vesicle (uEVs) excretion of mannan-binding lectin associated serine protease-2 (MASP-2). We hypothesized that MASP-2 is a physiologically relevant ENaC-activating protease. It was confirmed that MASP2 mRNA is abundantly present in liver but not in human and mouse kidneys. Aldosterone-stimulation of murine cortical colleting duct (mCCD) cells did not induce MASP-2 mRNA. In human kidney collecting duct, MASP-2 protein was detected in AQP2-negative/ATP6VB1-positive intercalated cells suggestive of MASP2 protein uptake. Plasma concentration of full-length MASP-2 and the short splice variant MAp19 were not changed in a cross-over intervention study in healthy humans with low (70 mmol/day) versus high (250 mmol/day) Na+intake despite changes in aldosterone. The ratio of MAp19/MASP-2 in plasma was significantly increased with a high Na+diet and the ratio correlated with changes in aldosterone and fractional Na+excretion. MASP-2 was not detected in crude urine or in uEVs. MASP2 activated an amiloride-sensitive current when co-expressed with ENaC inXenopusoocytes, but not when added to the bath solution. In monolayers of collecting duct M1 cells, MASP2 expression did not increase amiloride-sensitive current and in HEK293 cells, MASP-2 did not affect γENaC cleavage. MASP-2 is neither expressed nor co-localized and co-regulated with ENaC in the human kidney or in urine after low Na+intake. MASP-2 does not mediate physiological ENaC cleavage in low salt/high aldosterone settings.
Selective modulation of cortical population dynamics during neuroprosthetic skill learning
Authors: Zippi Ellen L. , You Albert K. , Ganguly Karunesh , Carmena Jose M. 
Published: September 2022

AbstractBrain-machine interfaces (BMIs) provide a framework for studying how cortical population dynamics evolve over learning in a task in which the mapping between neural activity and behavior is precisely defined. Learning to control a BMI is associated with the emergence of coordinated neural dynamics in populations of neurons whose activity serves as direct input to the BMI decoder (direct subpopulation). While previous work shows differential modification of firing rate modulation in this population relative to a population whose activity was not directly input to the BMI decoder (indirect subpopulation), little is known about how learning-related changes in cortical population dynamics within these groups compare.To investigate this, we monitored both direct and indirect subpopulations as two macaque monkeys learned to control a BMI. We found that while the combined population increased coordinated neural dynamics, this increase in coordination was primarily driven by changes in the direct subpopulation. These findings suggest that motor cortex refines cortical dynamics by increasing neural variance throughout the entire population during learning, with a more pronounced coordination of firing activity in subpopulations that are causally linked to behavior.
Lead-exposure associated miRNAs in humans and Alzheimer’s disease as potential biomarkers of the disease and disease processes
Authors: Wen Qingfeng , Verheijen Marcha , Wittens Mandy Melissa Jane , Czuryło Julia , Engelborghs Sebastiaan , Hauser Duncan , van Herwijnen Marcel H. M. , Lundh Thomas , Bergdahl Ingvar A. , Kyrtopoulos Soterios A. , de Kok Theo M. , Smeets Hubert J. M. , Briedé Jacco Jan , Krauskopf Julian 
Published: September 2022

AbstractAlzheimer’s disease (AD) is a neurodegenerative disease that eventually affects memory and behavior. The identification of biomarkers based on risk factors for AD provides insight into the disease since the exact cause of AD remains unknown. Several studies have proposed microRNAs (miRNAs) in blood as potential biomarkers for AD. Exposure to heavy metals is a potential risk factor for onset and development of AD. Blood cells of subjects that are exposed to lead detected in the circulatory system, potentially reflect molecular responses to this exposure that are similar to the response of neurons. In this study we analyzed blood cell-derived miRNAs derived from a general population as proxies of potentially AD-related mechanisms triggered by lead exposure. Subsequently, we analyzed these mechanisms in the brain tissue of AD subjects and controls. A total of four miRNAs were identified as lead exposure-associated with hsa-miR-3651, hsa-miR-150-5p and hsa-miR-664b-3p being negatively and hsa-miR-627 positively associated. In human brain derived from AD and AD control subjects all four miRNAs were detected. Moreover, two miRNAs (miR-3651, miR-664b-3p) showed significant differential expression in AD brains versus controls, in accordance with the change direction of lead exposure. The miRNAs’ gene targets were validated for expression in the human brain and were found enriched in AD-relevant pathways such as axon guidance. Moreover, we identified several AD relevant transcription factors such as CREB1 associated with the identified miRNAs. These findings suggest that the identified miRNAs are involved in the development of AD and might be useful in the development of new, less invasive biomarkers for monitoring of novel therapies or of processes involved in AD development.
Co-targeting CDK2 and CDK4/6 overcomes resistance to aromatase and CDK4/6 inhibitors in ER+ breast cancer
Authors: Al-Qasem Abeer J. , Alves Carla L. , Ehmsen Sidse , Tuttolomondo Martina , Terp Mikkel G. , Johansen Lene E. , Vever Henriette , Hoeg Luna V. A. , Elias Daniel , Bak Martin , Ditzel Henrik J. 
Published: September 2022

AbstractResistance to aromatase inhibitor (AI) treatment and combined CDK4/6 inhibitor (CDK4/6i) and endocrine therapy (ET) are crucial clinical challenges in treating estrogen receptor-positive (ER+) breast cancer. Understanding the resistance mechanisms and identifying reliable predictive biomarkers and novel treatment combinations to overcome resistance are urgently needed. Herein, we show that upregulation of CDK6, p-CDK2, and/or cyclin E1 is associated with adaptation and resistance to AI-monotherapy and combined CDK4/6i and ET in ER+ advanced breast cancer. Importantly, co-targeting CDK2 and CDK4/6 with ET synergistically impairs cellular growth, induces cell cycle arrest and apoptosis, and delays progression in AI-resistant and combined CDK4/6i and fulvestrant-resistant cell models and in an AI-resistant autocrine breast tumor in a postmenopausal xenograft model. Analysis of CDK6, p-CDK2, and/or cyclin E1 expression as a combined biomarker in metastatic lesions of ER+ advanced breast cancer patients treated with AI-monotherapy or combined CDK4/6i and ET revealed a correlation between high biomarker expression and shorter progression-free survival (PFS), and the biomarker combination was an independent prognostic factor in both patients cohorts. Our study supports the clinical development of therapeutic strategies co-targeting ER, CDK4/6 and CDK2 following progression on AI-monotherapy or combined CDK4/6i and ET to improve survival of patients exhibiting high tumor levels of CDK6, p-CDK2, and/or cyclin E1.
The Musashi proteins direct post-transcriptional control of protein expression and alternate exon splicing in vertebrate photoreceptors
Authors: Matalkah Fatimah , Jeong Bohye , Sheridan Macie , Horstick Eric , Ramamurthy Visvanathan , Stoilov Peter 
Published: September 2022

AbstractThe Musashi proteins, MSI1 and MSI2, are conserved RNA binding proteins with a role in the maintenance and renewal of stem cells. Contrasting with this role, terminally differentiated photoreceptor cells express high levels of MSI1 and MSI2, pointing to a role for the two proteins in vision. Combined knockout of Msi1 and Msi2 in mature photoreceptor cells abrogated the retinal response to light and caused photoreceptor cell death. In photoreceptor cells the Musashi proteins perform distinct nuclear and cytoplasmic functions. In the nucleus, the Musashi proteins promote splicing of photoreceptor-specific alternative exons. Surprisingly, conserved photoreceptor-specific alternative exons in genes critical for vision proved to be dispensable, raising questions about the selective pressures that lead to their conservation. In the cytoplasm MSI1 and MSI2 activate protein expression. Loss of Msi1 and Msi2 lead to reduction in the levels of multiple proteins including proteins required for vision and photoreceptor survival. The requirement for MSI1 and MSI2 in terminally differentiated photoreceptors alongside their role in stem cells shows that, depending on cellular context, these two proteins can control processes ranging from cell proliferation to sensory perception.
Improving the stability of inverted perovskite solar cells towards commercialization
Authors: Li Bowei , Zhang Wei 
Published: September 2022

AbstractInverted perovskite solar cells (IPSCs) have great potential for commercialization, in terms of compatibility with flexible and multijunction solar cells. However, non-ideal stability limits their entry into the market. To shed light on the unstable origins of IPSCs, an analysis of recent research progress is needed. Here, we systematically discuss the stability of IPSCs, including each functional layer, interface and entire device, and consider environmental and operational stressors. We summarize a range of strategies for improving device stability and discuss the significance of stability test protocols. Finally, we highlight the shortcomings of current approaches for stability improvement and assessment, and provide recommendations for improving the stability of IPSCs.
Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease
Authors: Lewis Amy , Sánchez Saray , Berti Giulio , Pan-Castillo Belen , Nijhuis Anke , Mehta Shameer , Eleid Liliane , Gordon Hannah , Gadhok Radha , Kimberley Christopher , Minicozzi Annamaria , Chin-Aleong Joanne , Feakins Roger , Kypta Robert , Lindsay James Oliver , Silver Andrew 
Published: September 2022

Abstract
Intestinal fibrosis and stricture formation is an aggressive complication of Crohns disease (CD), linked to increased morbidity and costs. The present study investigates the contribution of Wingless-Int-1 (Wnt) signalling to intestinal fibrogenesis, considers potential cross-talk between Wnt and transforming growth factor β1 (TGFβ) signalling pathways, and assesses the therapeutic potential of small-molecule Wnt inhibitors.
β-catenin expression was explored by immunohistochemistry (IHC) in formalin-fixed paraffin embedded (FFPE) tissue from patient-matched nonstrictured (NSCD) and strictured (SCD) intestine (n=6 pairs). Functional interactions between Wnt activation, TGFβ signalling, and type I collagen (Collagen-I) expression were explored in CCD-18Co cells and primary CD myofibroblast cultures established from surgical resection specimens (n=16) using small-molecule Wnt inhibitors and molecular techniques, including siRNA-mediated gene knockdown, immunofluorescence (IF), Wnt gene expression arrays, and western blotting. Fibrotic SCD tissue was marked by an increase in β-catenin-positive cells. In vitro, activation of Wnt-β-catenin signalling increased Collagen-I expression in CCD-18Co cells. Conversely, ICG-001, an inhibitor of β-catenin signalling, reduced Collagen-I expression in cell lines and primary CD myofibroblasts. TGFβ increased β-catenin protein levels but did not activate canonical Wnt signalling. Rather, TGFβ up-regulated WNT5B, a noncanonical Wnt ligand, and the Wnt receptor FZD8, which contributed directly to the up-regulation of Collagen-I through a β-catenin-independent mechanism. Treatment of CCD-18Co fibroblasts and patient-derived myofibroblasts with the FZD8 inhibitor 3235-0367 reduced extracellular matrix (ECM) expression. Our data highlight small-molecule Wnt inhibitors of both canonical and noncanonical Wnt signalling, as potential antifibrotic drugs to treat SCD intestinal fibrosis. They also highlight the importance of the cross-talk between Wnt and TGFβ signalling pathways in CD intestinal fibrosis.
Development and prospect of monitoring and prevention methods of icing disaster in China power grid
Authors: Dong Bingbing , Jiang Xingliang , Yin Fanghui 
Published: September 2022

AbstractIcing disaster is one of the most serious threats to power grid security in China. This article provides a brief glance of current China's monitoring and prevention methods of icing disaster (MPI) development status. Despite a late start, China's research and development on MPI have made outstanding achievements, including formation mechanism causing ice disaster, key technologies and characteristics, and anti/de‐icing approaches development and application. It is apparent that Chinese scientists and engineers confronted the worldwide problem of anti/de‐icing, and put forward a comprehensive solution, which plays a more critical role in icing disaster prevention and reduction of power grid during the past 15 years. The article states that the anti/de‐icing devices have been applied successively to severe icing issues. These achievements are leading the world in the development and application of MPI. However, it is only at the extreme ice and snow conditions that can test and verify whether prevention methods are comprehensive and perfect or not. And the authors discovered the application limitations in the existing achievements. The article also discusses the overall development trends of MPI in the areas of key technological and technical breakthroughs and application scenarios etc. These discussions serve as references for MPI's future technological advancement and its ever‐expanding applications.
Special‐angle‐based signal injection sensorless control of IPMSM for suppressing multiple zero‐crossings of phase current
Authors: Tian Lisi , Wang Zaixiang , Zhang Hao , Wang Zheng , Guo Xin 
Published: September 2022

AbstractPulsating high‐frequency signal injection has the problem of multiple zero‐crossings when the phase current crosses zero‐point, which deteriorates the distortion of high‐frequency current caused by the zero‐current‐clamping effect. Thus, the accuracy of position observation is affected. To suppress multiple zero‐crossings, improved sinusoidal and square‐wave signal injection schemes are proposed. First, the relationship between the injection angle of the high‐frequency signal and the phase of the high‐frequency response current amplitude function is analysed. Based on the relationship, a special injection angle is calculated. By injecting the pulsating signal in the obtained special angle, the phase of the high‐frequency current is shifted. The amplitude of the high‐frequency response current is minimum when the fundamental frequency current crosses zero, thus reducing zero‐crossing points of phase current. Furthermore, the error signal extraction scheme applicable to arbitrary angle injection is designed to observe rotor position. The proposed high‐frequency signal injection method minimises the zero‐crossings of the phase current at any value of the torque angle. Both of the novel sinusoidal pulsating injection sensorless control scheme and square‐wave injection sensorless control scheme are confirmed by experiments on a 2.2‐kW interior permanent magnet synchronous motor (IPMSM) drive platform.
A novel approach to touch voltage risk assessment for gas pipelines in shared transmission corridors
Authors: Chan Keith Man‐Kei , Baguley Craig Antony , Madawala Udaya K. 
Published: September 2022

AbstractTouch voltages are more likely to appear on long‐distance pipelines that lie in shared corridors with transmission lines. The touch voltage level varies with soil resistivity and can become hazardous while maintenance is being undertaken, necessitating risk assessment. Therefore, a novel approach is proposed that achieves better accuracy in the risk assessment of hazardous touch voltages appearing on pipelines than current approaches. The proposed approach incorporates soil resistivity measurements taken over a 1‐year period, allowing for the derivation of soil models, touch voltage hazard profiles versus time and, thus, a probability reduction factor that can be integrated into a probabilistic risk calculation. Using a probability reduction factor is a key aspect to improving the accuracy of risk assessment, allowing pipeline asset operators to clearly identify whether or not, risk mitigation action is required. Further, the proposed approach allows appropriate risk mitigation actions to be identified. The efficacy and significance of the proposed approach are demonstrated through a case study on an area of land near a shared gas pipeline and transmission line corridor. The case study results show how appropriate safety levels can be achieved by adjusting the number of work day per year and temporary protection settings.
Descemet-Membran-Endothel-Keratoplastik in Kombination mit Pars-plana-Vitrektomie in komplexen Augen zur extensiven Gastamponade
Authors: Loi Yi Ming Emily , Geerling Gerd 
Published: September 2022

Zusammenfassung
Hintergrund Die DMEK ist ein etabliertes Verfahren, um endotheliale Hornhauterkrankungen zu behandeln. Dabei wird eine Endotamponade der Vorderkammer genutzt, um das Transplantat am
Empfängerbett zu fixieren. Bei Z. n. nach Aphakisierung, großen Irisdefekten oder fistulierender Glaukomoperation kommt es oft früh postoperativ zum Verlust der Gastamponade in den
Glaskörperraum oder nach subkonjunktival. Wir berichten über 3 Fälle, bei denen eine simultane Gastamponade der Vorder- und Hinterkammer durch primäre Kombination von DMEK und
23-G-Pars-plana-Vitrektomie (ppV) durchgeführt wurde.
Fallbeschreibungen Im 1. Fall zeigte sich bei einem 70-jährigen Mann früh postoperativ nach DMEK eine vollständige Gasdislokation in den Glaskörperraum, sodass ein Re-Bubbling in
Kombination mit einer 23-G-ppV durchgeführt wurde. In Fall 2 wurde bei einem 80-jährigen Mann aufgrund eines vorhandenen Ahmed-Glaukom-Implantates und in Fall 3 bei einer 61-jährigen Frau
mit traumatischer Aphakie die DMEK unmittelbar mit einer ppV kombiniert. In allen Fällen erfolgte eine bestmögliche Gasfüllung von Glaskörperraum und Vorderkammer mittels 20% SF6.
In Fall 2 wurde ein Re-Bubbling aufgrund einer partiellen Transplantatdehiszenz am 5. Tag nach DMEK erforderlich. In allen Fällen blieb der intraokulare Druck postoperativ kompensiert und es
kam trotz der visuslimitierenden komplexen Vorerkrankungen zu einem Visusanstieg.
Diskussion Die kombinierte Endotamponade von Vorder- und Hinterkammer im Rahmen einer DMEK mit 23-G-ppV kann bei Augen mit komplexer Vorgeschichte die Gasendotamponade verlängern und
so eine erfolgreiche Transplantatadhärenz sichern.
Decentralizing corporate governance? A praxeological inquiry
Authors: Mitchell Scott L. , Packard Mark D. , Clark Brent B. 
Published: September 2022

AbstractThe theory and practice of corporate governance has been in something of an arms race with corporate malefactors—as corporate governance mechanisms have incrementally advance, so too have the strategies of malefactors who skirt those governance practices to engage in costly misconduct. Modern centralized governance approaches appear inapt to filling the gaps caused by agency and knowledge problems. Here, we start afresh using the atypical ‘praxeological’ method to reconstruct governance theory anew from basic foundations. The resultant theory is distinctive from prevailing corporate governance theorizing in several key ways. One of the more important conclusions from our reconstructed theory is that governance may benefit from a more ‘market’ or decentralized approach. In short, the governance holes derived from agency and knowledge problems are, or may be, much smaller when governance is decentralized, where employees police each other. While the implementation of such a radical rethinking of governance practice is left ambiguous in our treatment, the theoretical basis for such an approach is compelling.