bluuebunny/crossref_metadata_2025_split huggingface dataset:
Limitations of Gravimetric Quantitative Blood Loss during Cesarean Delivery
Authors: Thurer Robert L. , Doctorvaladan Sahar , Carvalho Brendan , Jelks Andrea T. 
Published: February 2022

Objective This study examined the accuracy, sources of error, and limitations of gravimetric quantification of blood loss (QBL) during cesarean delivery.
Study Design Blood loss determined by assays of the hemoglobin content on surgical sponges and in suction canisters was compared with QBL in 50 parturients.
Results QBL was moderately correlated to the actual blood loss (r = 0.564; p < 0.001). Compared with the reference assay, QBL overestimated blood loss for 44 patients (88%). QBL deviated from the assayed blood loss by more than 250 mL in 34 patients (68%) and by more than 500 mL in 16 cases (32%). Assayed blood loss was more than 1,000 mL in four patients. For three of these patients, QBL was more than 1,000 mL (sensitivity = 75%). QBL was more than 1,000 mL in 12 patients. While three of these had an assayed blood loss of more than 1,000 mL, 9 of the 46 patients with blood losses of less than 1,000 mL by the assay (20%) were incorrectly identified as having postpartum hemorrhage by QBL (false positives). The specificity of quantitative QBL for detection of blood loss more than or equal to 1,000 mL was 80.4%.
Conclusion QBL was only moderately correlated with the reference assay. While overestimation was more common than underestimation, both occurred. Moreover, QBL was particularly inaccurate when substantial bleeding occurred.
Key Points
Does the Degree of Maternal Fever in the Setting of Chorioamnionitis Lead to Adverse Neonatal Outcomes?
Authors: Varvoutis Megan S. , Abdalla Azza E. , Dotters-Katz Sarah K. 
Published: February 2022

Objective The effect of the degree of maternal fever in the setting of chorioamnionitis on neonatal morbidity is unclear. The objective of this study is to assess the association between high maternal fevers (≥ 39°C) on neonatal morbidity.
Study Design Secondary analysis of Maternal-Fetal Medicine Units (MFMU) Cesarean Registry data obtained from 1999 to 2002 among singleton gestations with chorioamnionitis. Women with a temperature less than 39°C (low fever) compared with those with greater than or equal to 39°C (high fever). Primary outcome was a composite of adverse neonatal outcomes such as death, sepsis, necrotizing enterocolitis, grade-3 or -4 intraventricular hemorrhage, seizure within 24 hours of delivery, intubation within 24 hours of delivery, and requiring cardiopulmonary resuscitation. Demographic characteristics compared using Fisher's exact and Wilcoxon's rank-sum test as appropriate. Multivariate logistic regression analysis with performed to control for cofounders. Stratified analysis also performed to assess outcomes in term infants.
Results Of 1,313 included women, 1,200 (91.3%) were in the low fever group and 113 (8.7%) were in the high fever group. Women in the high fever group were more likely to be African American and group B Streptococcus positive. No difference in primary outcome was noted between the groups (38.9% high fever vs. 35.8% low fever, p = 0.54). High maternal fever was associated with increased risk of NICU admission (48.1 vs. 50.4%, p = 0.02). When controlling for African American race, preterm birth, and delivery route, patients with high fever were not more likely to have adverse neonatal outcomes (adjusted odds ratio [aOR] = 1.28, 95% confidence interval [CI]: 0.84, 1.98). In the analysis limited to term infants, when controlling for confounders, high fever, similarly, was not associated with increased odds of adverse neonatal outcomes (aOR = 1.59, 95% CI: 0.96, 2.65).
Conclusion The degree of maternal fever does not appear to be associated with an increased likelihood of adverse neonatal outcomes. Better understanding maternal factors that affect neonatal morbidity in the setting of chorioamnionitis is critical.
Key Points
Preconception Counseling: Identifying Ways to Improve Services
Authors: Burrows Khyla , Sheeder Jeanelle , Lijewski Virginia , Harper Teresa 
Published: February 2022

Abstract
Objective The aim of this retrospective study was to evaluate the maternal conditions for which preconception services are provided and the routine services and recommendations offered through the Maternal Fetal Medicine group at the University of Colorado (CU). The study sought to determine how services and recommendations differ by maternal condition, demographics, and reproductive health history.
Materials and Methods Charts of patients who received preconception counseling through the CU MFM department during 2018 were reviewed to evaluate maternal conditions and the type of counseling patients received. Patients were grouped by their referral reason and subsequently by counseling recommendations to either proceed with immediate conception, defer immediate conception pending completion of further recommendations or to not conceive.
Results Of the fifty-nine patients referred to preconception counseling, 52% (n = 31) of the women were referred for maternal disease, 40% (n = 24) for infertility, 32% (n = 19) for previous poor obstetric outcomes, 30% (n = 18) for advanced maternal age and finally, 15% (n = 9) for gynecologic anatomic abnormalities.
Conclusion During the initial evaluation, 58% (n = 34) of patients were determined to have no concern for immediate conception while 7% (n = 4) were ultimately advised to not conceive. Using this data, we identified areas of preconception counseling that standardization will improve by ensuring patients receive comparable services and advice.
Bleeding during Learning Curve of Thoracoscopic Lobectomy: CUSUM Analysis Results
Authors: Fiorelli Alfonso , Cascone Roberto , Carlucci Annalisa , Natale Giovanni , Noro Antonio , Bove Mary , Santini Mario 
Published: February 2022

Abstract
Background The management of intraoperative bleeding during thoracoscopic lobectomy is challenging, especially for non-experienced surgeons. We evaluated intraoperative bleeding in relation to learning curve of thoracoscopic lobectomy, the strategies to face it, the outcomes, and the target case number for gaining the technical proficiency.
Methods This was a retrospective single center study including consecutive patients undergoing thoracoscopic lobectomy for lung cancer. Based on cumulative sum analysis, patients were divided into early and late experience groups, and the differences on surgical outcomes, with particular focus on vascular injury, were statistically compared.
Results Eight-three patients were evaluated. Cumulative sum charts showed a decreasing of operative time, blood loss, and hospital stay after the 49th, the 43th, and the 39th case, respectively. Early (n = 49) compared with late experience group (n = 34) was associated with higher conversion rate (p = 0.08), longer operative time (p <0.0001), greater blood loss (p <0.0001), higher transfusion rate (p = 0.01), higher postoperative air leak rate (p = 0.02), longer chest tube stay (p <0.0001), and hospitalization (p <0.0001). Six patients (7%) had intraoperative bleeding during early phase of learning curve, successfully treated by thoracoscopy in four cases. Patients with vascular injury (n = 6) compared with control group (n = 77) presented a longer operative time (p = 0.003), greater blood loss (p = 0.0001), and higher transfusion rate (p = 0.001); no significant differences were found regarding postoperative morbidity (p = 0.57), length of chest tube stay (p = 0.07), and hospitalization (p = 0.07).
Conclusion Technical proficiency was achieved after 50 procedures. All vascular injuries occurred in the early phase of learning curve; they were safely managed, without affecting surgical outcomes.
Change in Columellar–Philtral and Nasolabial Angles Over Time Following Rhinoplasty
Authors: Brennan Tara E. , Trujillo Oscar , Sina Mehdi , Vandenberg Katherine N. , Myers Orrin , Pearlman Steven J. 
Published: February 2022

AbstractPreoperative analyses of the columellar–philtral and nasolabial angles (CPA and NLA) are important considerations for the rhinoplasty surgeon. This study aims to quantify and compare the degree of change in nasal tip rotation as measured by CPA and NLA over time following rhinoplasty and to identify surgical maneuvers or patient characteristics that may affect nasal tip rotation. Prospective analysis of CPA and NLA in 111 consecutive, consenting cosmetic, and/or functional rhinoplasty patients of the senior author over a 1-year time period was performed. Angles were analyzed before surgery, immediately after surgery, and at 1 week, 1 month, 6 months, and 1 year following surgery. Subgroup analyses based on surgical maneuvers and other covariates were performed. The greatest change to CPA and NLA in the upright position was 11.8 degrees (95% confidence interval [CI]: 9.8–13.7, p < 0.001) and 9.3 degrees (95% CI: 7.9–10.7, p < 0.001) of elevation 1 week after surgery, respectively. The mean CPA was not significantly different than preoperative measures 6 months after surgery; however, the NLA remained 4.94 degrees (95% CI: 2.1–8.4, p = 0.001) elevated. Females showed approximately 10 degrees more elevated CPA than males in pre- and postoperative time points; however, the NLA did not discriminate between sexes. Transfixion incisions appears to cause a significant decrease in postoperative NLA compared with patient who did not undergo transfixion incisions. Measurements for nasal tip rotation are variable and inconsistent throughout the literature. This study shows that rhinoplasty may have a greater effect on nasal tip rotation as measured by NLA and that the effects of NLA and CPA are independent, signifying that a standardized measurement for nasal tip rotation is warranted.
How do MNEs invent? An invention-based perspective of MNE profitability
Authors: Kafouros Mario , Hashai Niron , Tardios Janja Annabel , Wang Elizabeth Yi 
Published: February 2022

AbstractAlthough MNEs create inventions both internally and collaboratively with partners as well as within and across countries, we know very little about the effects that combining such inventive activities have on their profitability. This study develops an invention-based perspective that considers how MNEs' profitability is influenced by the ways they organize the development of inventions across organizational boundaries (internally or collaboratively) and geographic boundaries (within or across countries). This perspective postulates that profitability is not merely driven by advantageous technological endowments but also by how such technological assets have been created. Accordingly, it explains why specific combinations of inventive activities across the two boundaries affect the likelihood of creating breakthrough inventions differently, provide different revenue and cost advantages, and have different effects on MNEs’ profitability. It further explains why cross-country inventions contribute more to profitability when they are internalized, while within-country inventions are more profitable when they are created collaboratively.
Segmented correlation consistent basis sets for the 4d and 5d transition metals
Authors: Schoendorff George , Boatz Jerry A. 
Published: February 2022

The cc-pVnZ-PP and cc-pwCVnZ-PP (n = D, T, Q, 5) pseudopotential-based correlation consistent basis sets for the 4d and 5d transition metals were reoptimized to have segmented contraction schemes. Computed ionization potentials and dns2 → dn+1s1 excitation energies computed at the coupled cluster level of theory with single, double, and perturbative triple excitations using the segmented basis sets approximate the result obtained with the generally contracted basis sets with mean absolute deviations (MADs) within 0.75 kcal mol−1 for the ionization energies and 2 kcal mol−1 for the excitation energies with respect to the results obtained with the generally contracted basis. The segmented basis sets also retain the systematically convergent behavior of the correlation consistent basis sets with MADs within 0.61 kcal mol−1 with respect to the generally contracted basis for properties extrapolated to the complete basis set limit. The segmented nature of the seg-cc-pVnZ-PP and seg-cc-pwCVnZ-PP basis sets enables significant performance improvements when using algorithms with an a priori treatment of the contraction coefficients with average speedups in the time required to form the Fock matrix ranging from 6.1× for the seg-cc-pVDZ-PP basis sets to 53.8× for the seg-cc-pV5Z-PP basis sets.
Fungal gasdermin-like proteins are controlled by proteolytic cleavage
Authors: Clavé Corinne , Dyrka Witold , Turcotte Elizabeth A. , Granger-Farbos Alexandra , Ibarlosa Léa , Pinson Benoît , Vance Russell E. , Saupe Sven J. , Daskalov Asen 
Published: February 2022

Significance
The recent discovery of gasdermin-like proteins in fungi have brought to light that this family of pore-forming proteins controls cell death in two of the major eukaryotic kingdoms, fungi and mammals. Yet the regulation of cytotoxicity of the fungal gasdermins and their molecular pathways remain uncharacterized. Here, we describe the regulation through proteolytic cleavage of the fungal gasdermin HET-Q1 and uncover that a majority of fungal gasdermins are genomically clustered with protease-encoding genes. Some of these genes encode proteins with caspase-related domains and/or are members of a family of immune receptors in mammals and plants. Overall, this work contributes toward our understanding of the evolution of gasdermin-dependent cell death, enlightening multiple evolutionary parallels between signaling pathways in mammals and fungi.
Infrared triggered smart contact lens for the treatment of presbyopia
Authors: Bailey James , Clamp John , Farmer Steven , Gleeson Helen F , Haynes Tim , Jones J Cliff , Moorhouse Tom , Morgan Philip 
Published: February 2022

Abstract
A switchable contact lens prototype was fabricated and tested with integrated off the shelf electronic components to drive a liquid crystal (LC) active lens element. This prototype was capable of changing its focal power by an average of +1.9D, but a maximum of +3.2 ± 0.2D was also measured. Switchable focus contact lenses are intended to help restore functional near and intermediate vision accommodation to those suffering from presbyopia, an inevitable age-related eye condition. The custom poly-methyl-methacrylate contact lens substrates used in this prototype are equivalent to commercially available scleral contact lenses. It was discovered that more careful design considerations are needed when at least one of the substrates is <100 µm thick (which is needed for a final device). Without these design considerations, the switchable focal power of the lens is susceptible to change as the LC insert layer is able to flex. The prototype has an on-board electronics platform which was self-powered with a battery. Illuminating the electronics package with a 600 Hz infrared signal switched the device on, which passed an AC voltage to the electrodes of the contact lens, reorientating the director of the LC with an electric field. To our knowledge, this is the first demonstration of a battery powered and wirelessly triggered smart contact lens for the treatment of presbyopia.
Recent progress of heterostructures based on two dimensional materials and wide bandgap semiconductors
Authors: Liu Ying , Fang Yanjun , Yang Deren , Pi Xiaodong , Wang Peijian 
Published: February 2022

Abstract
Recent progress in the synthesis and assembly of two-dimensional (2D) materials has laid the foundation for various applications of atomically thin layer films. These 2D materials possess rich and diverse properties such as layer-dependent band gaps, interesting spin degrees of freedom, and variable crystal structures. They exhibit broad application prospects in micro-nano devices. In the meantime, the wide bandgap semiconductors (WBS) with an elevated breakdown voltage, high mobility, and high thermal conductivity have shown important applications in high-frequency microwave devices, high-temperature and high-power electronic devices. Beyond the study on single 2D materials or WBS materials, the multi-functional 2D/WBS heterostructures can promote the carrier transport at the interface, potentially providing novel physical phenomena and applications, and improving the performance of electronic and optoelectronic devices. In this review, we overview the advantages of the heterostructures of 2D materials and WBS materials, and introduce the construction methods of 2D/WBS heterostructures. Then, we present the diversity and recent progress in the applications of 2D/WBS heterostructures, including photodetectors, photocatalysis, sensors, and energy related devices. Finally, we put forward the current challenges of 2D/WBS heterostructures and propose the promising research directions in the future.
Influence of W doping on the structure, magnetism and exchange bias in Ni47Mn40Sn13−
x
W
x
Heusler alloys
Authors: Norouzi-Inallu M , Kameli P , Ghotbi Varzaneh A , Abdolhosseini Sarsari I , Abbasi Eskandari M , Orue I , Rodríguez-Crespo B , Chernenko V 
Published: February 2022

Abstract
The influence of the W-doping on the martensitic transformation, magnetic properties and exchange bias (EB) effect in the Ni47Mn40Sn13−x
W
x
(x = 0, 0.5, 1, 1.25 at.%) magnetic shape memory alloys has been investigated. It is found that the W-doping causes a simultaneous reduction of both the ferromagnetic (FM) exchange coupling and enhancement of the magnetic anisotropy, leading to a decrease of the magnetic moment of the low-temperature phase and to a higher attainable EB. The magnetic memory measurements reveal the presence of a glassy magnetic ground state, which can significantly impact the reduction of magnetization and enhancement of EB in the studied bulk alloys. It is argued that the glassy magnetic ground state originates from the partial magnetic disorder resulting from the correlation between the antiferromagnetic and FM states. The results demonstrate that the doping by W instead of Sn is an efficient tool to tailor the EB effect in the Ni–Mn–Sn-based Heusler alloys, whereby they are promising for spintronic applications.
Intermittent-contact local dielectric spectroscopy of nanostructured interfaces
Authors: Labardi M , Tripathi P , Capaccioli S , Casalini R 
Published: February 2022

Abstract
Local dielectric spectroscopy (LDS) is a scanning probe method, based on dynamic-mode atomic force microscopy (AFM), to discriminate dielectric properties at surfaces with nanometer-scale lateral resolution. Until now a sub-10 nm resolution for LDS has not been documented, that would give access to the length scale of fundamental physical phenomena such as the cooperativity length related to structural arrest in glass formers (2–3 nm). In this work, LDS performed by a peculiar variant of intermittent-contact mode of AFM, named constant-excitation frequency modulation, was introduced and extensively explored in order to assess its best resolution capability. Dependence of resolution and contrast of dielectric imaging and spectroscopy on operation parameters like probe oscillation amplitude and free amplitude, the resulting frequency shift, and probe/surface distance-regulation feedback gain, were explored. By using thin films of a diblock copolymer of polystyrene (PS) and polymethylmethacrylate (PMMA), exhibiting phase separation on the nanometer scale, lateral resolution of at least 3 nm was demonstrated in both dielectric imaging and localized spectroscopy, by operating with optimized parameters. The interface within lamellar PS/PMMA was mapped, with a best width in the range between 1 and 3 nm. Changes of characteristic time of the secondary (β) relaxation process of PMMA could be tracked across the interface with PS.
U-net architecture with embedded Inception-ResNet-v2 image encoding modules for automatic segmentation of organs-at-risk in head and neck cancer radiation therapy based on computed tomography scans
Authors: Siciarz Pawel , McCurdy Boyd 
Published: February 2022

Abstract

Purpose. The purpose of this study was to utilize a deep learning model with an advanced inception module to automatically contour critical organs on the computed tomography (CT) scans of head and neck cancer patients who underwent radiation therapy treatment and interpret the clinical suitability of the model results through activation mapping. Materials and methods. This study included 25 critical organs that were delineated by expert radiation oncologists. Contoured medical images of 964 patients were sourced from a publicly available TCIA database. The proportion of training, validation, and testing samples for deep learning model development was 65%, 25%, and 10% respectively. The CT scans and segmentation masks were augmented with shift, scale, and rotate transformations. Additionally, medical images were pre-processed using contrast limited adaptive histogram equalization to enhance soft tissue contrast while contours were subjected to morphological operations to ensure their structural integrity. The segmentation model was based on the U-Net architecture with embedded Inception-ResNet-v2 blocks and was trained over 100 epochs with a batch size of 32 and an adaptive learning rate optimizer. The loss function combined the Jaccard Index and binary cross entropy. The model performance was evaluated with Dice Score, Jaccard Index, and Hausdorff Distances. The interpretability of the model was analyzed with guided gradient-weighted class activation mapping. Results. The Dice Score, Jaccard Index, and mean Hausdorff Distance averaged over all structures and patients were 0.82 ± 0.10, 0.71 ± 0.10, and 1.51 ± 1.17 mm respectively on the testing data sets. The Dice Scores for 86.4% of compared structures was within range or better than published interobserver variability derived from multi-institutional studies. The average model training time was 8 h per anatomical structure. The full segmentation of head and neck anatomy by the trained network required only 6.8 s per patient. Conclusions. High accuracy obtained on a large, multi-institutional data set, short segmentation time and clinically-realistic prediction reasoning make the model proposed in this work a feasible solution for head and neck CT scan segmentation in a clinical environment.
True differential superconducting on-chip output amplifier
*
Authors: Egan Jonathan , Brownfield Andrew , Herr Quentin 
Published: February 2022

Abstract
The true-differential superconductor on-chip amplifier has complementary outputs that float with respect to chip ground. This improves signal integrity and compatibility with the receiving semiconductor stage. Both source-terminated and non-source-terminated designs producing 4 mV demonstrated rejection of a large common mode interference in the package. Measured margins are ±8.5% on the output bias, and ±28% on AC clock amplitude. Waveforms and eye diagrams are taken at 2.9–10 Gb

s

−
1

. Direct measurement of bit-error rates are better than the resolution limit of

1
×

10

−
12

at 2.9 Gb

s

−
1

, and better than

1
×

10

−
9

at 10 Gb

s

−
1

.
Study of post-arc residual plasma dissipation process of vacuum circuit breakers based on a 2D particle-in-cell model
Authors: MO Yongpeng , SHI Zongqian , JIA Shenli 
Published: February 2022

Abstract
In order to get an insight into residual plasma radial motion during the post-arc stage, a two-dimensional (2D) cylindrical particle-in-cell (PIC) model is developed. Firstly, influences of a virtual boundary condition on the residual plasma motion are studied. For purpose of validating this 2D cylindrical particle-in-cell model, a comparison between one-dimensional particle-in-cell model is also presented in this paper. Then a study about the influences of the rising rate of transient recovery voltage on the residual plasma radial motion is presented on the basis of the 2D PIC model.