bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-world observational study to capture demographic details of newly diagnosed type 2 diabetes mellitus
Authors: Dalal Nishant , Patel Dixit , Chaturvedi Alok , Shah Ankita 
Published: September 2022

Background: To understand the demographic profile of newly diagnosed type 2 diabetes mellitus (T2DM) patients and to evaluate the glycaemic status and initial treatment choices in this subset of T2DM patients.Methods: The ROD-IT-2 study was a real-world, retrospective, cross-sectional, observational study conducted at various centres across India between April 2021 and March 2022. The study outcomes included epidemiology, comorbidities, and management strategies preferred by Indian clinicians in these patients.Results: Data from 29,550 newly diagnosed T2DM patients were analyzed. The mean age of patients was 53.3 years, and majority were males (65%). Majority of patients (63.85%) were aged 40 to 60 years. More than half (53.11%) of the patients were either overweight (36.65%) or obese (16.76%). The mean glycated hemoglobin (HbA1c) was high (8.4%). Most (88.5%) patients had cardio-renal comorbidities. Hypertension was the most common comorbidity (45.7%) followed by dyslipidemia (32.1%). Chronic kidney disease (CKD) was also present in 31.2% patients. In the present study, 9.2% patients presented with microvascular complications at the time of diagnosis. Majority of newly diagnosed patients (79.7%) were treated with combination therapy. In patients who were prescribed dual drug combination therapy, metformin + dipeptidyl peptidase-4 inhibitor (DPP4i) was the preferred combination (42.71%) followed by metformin + sulfonylurea (31.37%).Conclusions: ROD-IT-2 study showed that mean HbA1c levels in T2DM patients still remain high in our population and cardio-renal comorbidities remain prevalent in newly diagnosed patients. Indian clinicians were found to prefer the combination therapy in newly diagnosed T2DM patients.
EFICIÊNCIA TÉCNICA E ECONÔMICA DO CAPIM-JIGGS (Cynodon dactylon (L.) Pers.) SUBMETIDO A DIFERENTES DOSES DE ADUBAÇÃO MINERAL E ORGANOMINERAL
Authors: ZANROSSO Evandro , BUSNELLO Fábio José , Olias Caroline , SAUER Aline Vanessa , LAJÚS Cristiano Reschke 
Published: September 2022

Para expressar seu potencial o Capim-Jiggs depende de condições edafoclimáticas específicas, além da fertilidade do associando à doses de adubação mineral e organomineral, justificando a avaliação da capacidade adaptativa e o potencial forrageiro na região, implicando em produção animal abaixo do preconizado. A pesquisa possuiu por objetivo avaliar a eficiência técnica e econômica do Capim-Jiggs submetido a doses de adubação mineral e organomineral. O experimento foi implantado na área rural localizada no Município de Chapecó-SC, durante o segundo semestre de 2020 e primeiro semestre de 2021. O delineamento experimental foi o Delineamento em Blocos Casualizados (DBC) em esquema de parcela subdividida ao longo do tempo (5 x 4), com 5 repetições, sendo que na parcela principal foram alocadas as adubações (Testemunha; 50% da dose recomendada de adubo organomineral – 250kg de 10-10-10; 100% da dose recomendada de adubo organomineral – 500kg de 10-10-10;150% da dose recomendada de adubo organomineral – 750kg de 10-10-10 e Adubação mineral – 240 kg de 09-24-10 e nas subparcelas ao longo do tempo foram alocados os cortes (1º Corte: 02/01/21; 2º Corte: 04/02/21; 3º Corte: 25/03/21 e 4º Corte: 10/05/21). Objetivando-se determinar a máxima eficiência técnica (MET), o material coletado na área útil (0,5m²) foi identificado e pesado. Os dados coletados foram submetidos à Análise de Variância (ANOVA) pelo teste F (P≤0,05), as diferenças entre as médias foram comparadas pelo Teste de Tukey (P≤0,05). Concluindo-se que a dose recomendada de 150% de adubo organomineral se equivale a dose recomendada da adubação mineral, com base na MET e MEE do Capim-Jiggs.
Comparison of the effectiveness of coping with job stress training with mindfulness-based cognitive therapy on perception of work-family conflict and life satisfaction of employed retirees
Authors: Goudarzi Mohammad Hosein , Mehdad Ali , Golparvar Mohsen 
Published: September 2022

Background: Retirement is a stage in life in which retirees are less satisfied with their retirement. It is essential to study the issues of the post-retirement period and the role of their re-employment on mental and physical health. Therefore, the present study aimed to compare the effectiveness of coping with job stress training with mindfulness-based cognitive therapy on the perception of work-family conflict and the life satisfaction of employed retirees.
Materials and Methods: The study is quasi-experimental with three groups and three stages. The statistical population was all retirees aged 45 to 65 who were members of Isfahan Retirement Centers in the winter of 1400. Using convenience sampling, 45 persons were selected and randomly assigned to three groups. The work-family conflict (Carlson et al., 2000) and the life satisfaction questionnaires (Diener et al., 1985) were used to collect data. Data were analyzed by analysis of covariance and SPSS 24 software.
Results: The results showed a significant difference in the work-family conflict in the post-test stage between the experimental and control groups (p <0.05). In the follow-up stage, there is a significant difference only between the coping with job stress group and the control group.
Moreover, there is a significant difference in life satisfaction between the experimental and control groups in the post-test and follow-up stages (p <0.05). The results of Bonferroni’s post hoc test showed that the effect of coping with job stress training is more significant than mindfulness-based cognitive therapy.
Conclusion: The study provides empirical support for both training to reduce work-family conflict and increase life satisfaction in employed retirees. According to Bonferroni’s post hoc test results, coping with job stress training is recommended.
Comparison of Extubation of Patients in Prone versus Supine Position in workers Undergoing Lumbar Disc Surgery
Authors: Dehghani Mohammad Hossein , Khoshrou Ali Asghar 
Published: September 2022

Introduction: This study compared the extubation of patients in prone versus supine positions in patients undergoing lumbar disc surgery.
Material and Methods: In this single-blind clinical trial, 60 patients who were candidates for elective lumbar disc surgery were selected and randomly assigned into two groups of 30 patients. All patients primarily underwent surgery in the prone position. After surgery and discontinuation of anesthesia gases (T0), patients were assigned into two groups, prone and supine. From T0 to extubation time, heart rate, systolic and diastolic blood pressure, mean arterial pressure, Spo2, cough severity, and secondary complications after extubation such as laryngospasm and shortness of breath were measured and recorded in both groups.
Results: The results showed that in all the variables under study, the supine group had higher values than the prone group. There was a significant difference in oxygen pressure between the two groups, and the prone group had a more suitable status than the supine group (P=0.02). The incidence of cough was higher in the supine group compared to the prone group, and the observed difference was significant (P=0.001).
Conclusion: Based on the findings of this study, maintaining the prone position after lumbar disc surgery for extubation causes the patient to be less affected by the change of position and is in a superior status in terms of coughing and oxygen pressure.
Fixed-Bearing Trabecular Metal Total Ankle Arthroplasty Using the Transfibular Approach for End-Stage Ankle Osteoarthritis
Authors: D’Ambrosi Riccardo , Tiusanen Hannu Tapani , Ellington John Kent , Kraus Fabian , Younger Alastair , Usuelli Federico Giuseppe 
Published: September 2022

Background:
This multicenter prospective cohort study assessed the safety and performance of the Trabecular Metal Total Ankle System (TM Ankle; Zimmer) for primary total ankle arthroplasty (TAA).

Methods:
One hundred and twenty-one consecutive patients qualifying for primary TAA were enrolled in the study. All patients received the TM Ankle implant. Clinical outcome examinations and radiographic evaluations were conducted at 6 weeks, 6 months, 1 year, 2 years, and 3 years. Patient-reported outcome measures (PROMs) were evaluated with use of the EuroQol-5 Dimensions questionnaire (EQ-5D), Ankle Osteoarthritis Scale (AOS), American Orthopaedic Foot & Ankle Society questionnaire (AOFAS), and patient satisfaction at each time point. Complications were classified according to the Canadian Orthopaedic Foot and Ankle Society (COFAS) system.

Results:
The average AOFAS, EQ-5D, AOS pain, and AOS difficulty scores showed significant improvement at 6 weeks, 6 months, 1 year, 2 years, and 3 years as compared with the preoperative baseline (p < 0.001). The Kaplan-Meier survival estimate for revision when used in primary cases was 97.35% at 3 years. During the 3 years of follow-up, 9 patients showed abnormal radiographic findings. Two ankles had intraoperative complications, 38 had complications that were non-surgical or device-related, and 3 ankles underwent revision.

Conclusions:
The results of the present study indicated that patient well-being significantly increased following TAA with use of the TM Ankle. Radiographic parameters also demonstrated a low incidence of abnormal findings.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
The Component of the TAC Complex, TCD7, Controls Rice Chloroplast Development at the Early Seedling Stage under Cold Stress
Authors: Lin Dongzhi , Kang Licheng , Zhou Wenhao , Wang Yulu , Chen Yu , Xu Jianlong , Dong Yanjun 
Published: September 2022

Abstract
Transcriptionally active chromosome (TAC) is a component of protein-DNA complexes with RNA polymerase activity found in chloroplasts. Although TAC in Arabidopsis thaliana has been extensively investigated, how the rice (Oryza sativaL.) TAC complex functions remain largely unknown. We report the characterization of the mutant thermosensitive chlorophyll-deficient7 (tcd7) and the cloning of TCD7. tcd7 mutant seedlings displayed an albino phenotype specifically at low temperatures and before the four-leaf stage. We identified TCD7 by map-based cloning followed by transgenic rescue and genome editing tests, showing that TCD7 encodes the putative TAC component FRUCTOKINASE-LIKE 2 (OsFLN2). TCD7 transcripts were highly abundant in green tissues, and the protein localized to chloroplasts. In agreement with the albino phenotype, transcript levels of genes controlling chloroplast development and the establishment of photosynthetic capacity were severely reduced in tcd7 seedlings at low temperatures, but were expressed as in the wild type at high temperatures, implying that TCD7 regulates the PEP pathway and chloroplast development. Moreover, TCD7 interacted with the thioredoxin OsTRXz to form an OsTRXz-TCD7 regulatory module, which might regulate plastid transcription under cold stress. Our results demonstrate that the nucleus-encoded TAC protein TCD7protects chloroplast development from cold stress via a TRXz-FLN regulatory module.
An improved cooperation search algorithm for the multi-degree reduction of Ball Bézier surfaces
Authors: Cao Huanxin , Zheng Hongchan , Hu Gang 
Published: September 2022

Abstract
Cooperation search algorithm (CSA) is a new metaheuristic algorithm inspired from the team cooperation behaviors in modern enterprises and is characterized by fast convergence. However for some complex problems, it may get trapped into local optima and suffer from premature convergence for the shortcoming of population updating guided only by leading individuals. In this paper, an improved cooperation search algorithm (CCSA) is proposed by incorporating the mutation and crossover operators in DE algorithms to alleviate the shortcoming. The two operators can be used to increase population's diversity significantly, and thus improve population's exploration capability and accuracy significantly. CCSA has been tested on 23 benchmark functions and CEC 2017 benchmark suite. Experimental results demonstrate the better performance of CCSA on convergence speed and accuracy as compared to other existing optimizers. Furthermore, aiming at the problem that there is no universal approach for the multi-degree reduction of Ball Bézier surfaces under different interpolation constrains, we propose a new method to solve this problem by introducing metaheuristic methods, where the change of interpolation constrains are treated as the change of decision variables. The modeling examples show that the proposed method is effective and easy to implement under different interpolation constrains, which achieves the automatic and intelligent degree reduction of Ball Bézier surfaces.
Strong Conformable Structure via Tension Activated Kirigami
Authors: Corrigan Tom , Fleming Patrick , Eldredge Charlie , Langer-Anderson Delony 
Published: September 2022

Abstract
Kirigami, the cutting and folding of sheets, creates three-dimensional shapes from flat material. Known for centuries by artists and the subject of recent research, practical application of kirigami is limited by the complexity of the folding step. One kirigami pattern, a series of staggered slits, has been used for expanded metal gratings and packaging material. Because it deploys with simple tension, not complex folding, we call it Tension Activated Kirigami (TAK). In this paper, we introduce a new TAK pattern that drives flat material into rows of vertical, accordion-like, folded walls. This array of walls has a stiffness and strength comparable to a full honeycomb core, yet it self-deploys under tension. The structure is also conformable, allowing it to wrap around objects. These attributes enable a new paradigm for low-cost structural panels and a sustainable alternative to plastic cushion wrap.
Power analyses for response shift detection with structural equation modeling
Authors: Verdam Mathilde G. E. 
Published: September 2022

Abstract
Purpose. Statistical power for response shift detection with structural equation modeling (SEM) is currently underreported. The present paper addresses this issue by providing worked-out examples and syntaxes of power calculations relevant for the statistical tests associated with the SEM approach for response shift detection.
Methods. Power calculations and related sample-size requirements are illustrated for two modelling goals: 1) to detect misspecification in the measurement model, and 2) to detect response shift. Power analyses for hypotheses regarding (exact) overall model fit and the presence of response shift are demonstrated in a step-by-step manner. The freely available and user-friendly R-package lavaan and shiny-app ‘power4SEM’ are used for the calculations.
Results. Using the SF-36 as an example, we illustrate the specification of null-hypothesis (H0) and alternative hypothesis (H1) models to calculate chi-square based power for the test on overall model fit, the omnibus test on response shift, and the specific test on response shift. For example, we show that a sample size of 506 is needed to reject an incorrectly specified measurement model, when the actual model has two-medium sized cross loadings. We also illustrate an alternative power calculation based on the RMSEA index for approximate fit, where H0 and H1 are defined in terms of RMSEA-values.
Conclusion. By providing accessible resources to perform power analyses and emphasizing the different power analyses associated with different modeling goals, we hope to facilitate the uptake of power analyses for response shift detection with SEM and thereby enhance the stringency of response shift research.
R3-MYB repressor Mybr97 is a candidate gene associated with the Anthocyanin3 locus and enhanced anthocyanin accumulation in maize
Authors: Paulsmeyer Michael N. , Juvik John A. 
Published: September 2022

Abstract
Anthocyanins are colorful molecules receiving recent attention due to their numerous health benefits and applications as natural colorants and nutraceuticals. Purple corn is being investigated as a more economical source of anthocyanins. Anthocyanin3 (A3) is a known recessive intensifier of anthocyanin pigmentation in maize. In this study, anthocyanin content was elevated 100-fold in recessive a3 plants. Two approaches were used to discover candidates involved with the a3 intense purple plant phenotype. First, a large-scale transposon-tagging population was created with a Dissociation (Ds) insertion in the nearby Anthocyanin1 gene. A de novo a3-m1::Ds mutant was generated and the transposon insertion was found to be located in the promoter of Mybr97, which has homology to R3-MYB repressor CAPRICE in Arabidopsis. Second, a bulk segregant RNA-sequencing population found expression differences between pools of green A3 plants and purple a3 plants. All characterized anthocyanin biosynthetic genes were upregulated in a3 plants along with several genes of the monolignol pathway. Mybr97 was highly downregulated in a3 plants, suggesting its role as a negative regulator of the anthocyanin pathway. Photosynthesis-related gene expression was reduced in a3 plants through an unknown mechanism. Numerous transcription factors and biosynthetic genes were also upregulated and need further investigation. Mybr97 may inhibit anthocyanin synthesis by associating with basic-helix-loop-helix transcription factors like Booster1. Overall, Mybr97 is the most likely candidate gene for the A3 locus. A3 has a profound effect on the maize plant and has many favorable implications for crop protection, human health, and natural colorant production.
Effects of peppermint oil in patients with irritable bowel syndrome: a systematic review and meta-analysis
Authors: Huang Ziqing , Huang Xiaomei , Wan Ying 
Published: September 2022

Abstract
Backgroud: The purpose of this meta-analysis was to investigate the clinical effects of peppermint oil (PO) on the treatment of irritable bowel syndrome（IBS).
Methods: Randomized controlled trials of PO for the treatment of irritable bowel syndrome were retrieved by computer from PubMed, Cochrane CENTRAL, EMBASE, and Web of science until December 30, 2021, and a meta-analysis was performed using Revman5.3 software.
Results: Seven high-quality studies included a total of 722 participants. PO improved both IBS Symptom Severity Scale (IBS-SSS) and IBS quality of life (IBS-QOL) scores, although not significantly better than placebo(IBS-SSS ：MD = 15.35, 95% CI: -25.16-55.86, P = 0.46;IBS-QOL：MD = 0.78, 95% CI: -0.18-1.74, P = 0.11)；IBS-Global improvement in symptoms (IBS-GIS）of the PO group improved significantly compared with the placebo group (RR = 1.62, 95% CI: 1.20-2.17, P = 0.002). The PO group had significantly higher adverse events than the placebo group (RR 1.48, 95% CI: 1.48-1.89, P = 0.0002).
Conclusions: While PO can significantly alleviate the clinical symptoms of IBS, the occurrence of adverse events will increase, and whether it will enhance IBS-SSS or IBS-QOL scores has to be researched further.
Can patient registries contribute to guideline-based healthcare? A retrospective analysis of the CEDATA-GPGE registry for pediatric inflammatory bowel disease
Authors: Leiz Maren , Knorr Melanie , Moon Kilson , Tischler Luisa , Sohrabi Keywan , Cantez Serdar , Däbritz Jan , de Laffolie Jan , Berg Neeltje van den 
Published: September 2022

Abstract
Background: Early diagnosis is mandatory for the medical care of children and adolescents with pediatric-onset inflammatory bowel disease (PIBD). International guidelines (‘Porto criteria’) of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition recommended adequate medical diagnostic procedures in PIBD. Since 2004, German and Austrian pediatric gastroenterologists document diagnostic and treatment data in the patient registry CEDATA-GPGE. The aim of this retrospective study was to analyze whether the registry CEDATA-GPGE reflects the Porto criteria and to what extent diagnostic measures of PIBD according to the Porto criteria are documented.
Methods: Data of CEDATA-GPGE were analyzed for the period December 2013 to December 2018. Variables representing the Porto criteria for initial diagnostic were identified and categorized. The average of the number of measures documented in each category was calculated for the diagnoses CD, UC, and IBD-U. Differences between the diagnoses were tested by Chi-square test. Data on possible differencesbetween data documented in the registry and diagnostic procedures that were actually performed were obtained via a sample survey.
Results: There were 547 patients included in the analysis. The median age of patients with incident CD (n=289) was 13.6 years (IQR: 11.2-15.2), of patients with UC (n=212) 13.1 years (IQR: 10.4-14.8) and of patients with IBD-U (n=46) 12.2 years (IQR: 8.6-14.7).
The variables identified in the registry fully reflect the recommendations by the Porto criteria. Only the disease activity indices PUCAI and PCDAI were not included. The category ‘Case history’ were documented for the largest part (78.0%), the category ‘Imaging of the small bowel’ were documented least frequently (39.1%). In patients with CD, the categories ‘Imaging of the small bowel’ (χ2=20.7, Cramer-V=0.2, p<0.001) and ‘Puberty stage’ (χ2=9.8, Cramer-V=0.1, p<0.05) were documented more often than in patients with UC and IBD-U.
Conclusion: The registry fully reproduces the guideline’s recommendations for the initial diagnosis of PIBD. The proportion of documented diagnostic examinations varied within the diagnostic categories and between the diagnoses. Despite technological innovations, time and personnel capacities at participating centers and study center are necessary to ensure reliable data entry and to enable researchers to derive important insights into guideline-based care.