bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role and place of radiotherapy in neoadjuvant treatment of pancreatic cancer
Authors: Zemskov S.V. , Dronov O.I. , Burmich K.S. , Renz Paul , Kirichenko O. , Wellner Ulrich , Bolm Louisa , Keck Tobias , Khairnasov R.N. , Zemskova O.V. 
Published: May 2022

Background. Myocardial revascularization is a life-saving technology, which contributes to increase in lifespan, reduction in myocardial infarction recurrences and repeated surgeries along with improved life quality of the patients with coronary artery disease (CAD). Estimation of the risks, severity of coronary bed lesion, presence of concomitant diseases, and area of hibernating myocardium, as well as patient’s agreement are the basis of treatment method selection. Positive structural and functional changes in myocardium (increase in area of viable myocardium), restoration or improvement of systolic function of left ventricle (increase in ejection fraction and decrease in end-diastolic volume), reduction of angina symptoms are the expected results from the surgical treatment.
Purpose – to determine the influence of risk factors for coronary artery disease on the outcome of surgical treatment by the method of aorto-coronary artery bypass grafting with the help of diagnostic evaluation of myocardial scintigraphy parameters.
Materials and methods. For the implementation of the clinical objectives, 62 patients with coronary artery disease were examined. The average age of the patients was 59.6 ± 8.2 years. Myocardial scintigraphy was performed in the SPECT mode with ECG synchronization (Gated SPECT). 99mTc-MIBI with an activity of 555-740 MBq was used. Myocardial scintigraphy was conducted over time of treatment (before and after coronary artery bypass grafting) according to One Day Rest protocol.
Results. The influence of risk factors was assessed using dynamic and static integral indices. The dynamic integral index didn’t reveal statistically significant risk factors: smoking (p = 0.54), left ventricular contractility impairment (p = 0.43), history of myocardial infarction (p = 0.4), stage of heart failure (p = 0.53), and functional class of angina (p = 0.08). The static integral index didn’t reveal statistically significant influence as well: smoking (p = 0.13), left ventricular contractility impairment (p = 0.58), history of myocardial infarction (p = 0.1), stage of heart failure (p = 0.11), and functional class of angina (p = 0.6).
Conclusions. The studied risk factors for coronary artery disease, namely: history of myocardial infarction, left ventricular contractility impairment, stage of heart failure, functional class of angina, and smoking in the study group of patients had no registered influence on the revascularization effect by coronary artery bypass grafting method (integrated static and dynamic indices p > 0.05).
The use of biological disease-modifying antirheumatic drugs and Janus kinase inhibitors in rheumatoid arthritis during the COVID-19 coronavirus disease pandemic: data from a telephone survey of 254 patients
Authors: Karateev A. E. , Polishchuk E. Yu. , Potapova A. S. , Matyanova E. V. , Semashko A. S. , Bobkova А. O. , Filatova E. S. , Amirjanova V. N. , Glukhova S. I. , Zotkin E. G. , Lila A. M. 
Published: May 2022

The prescribing of biological disease-modifying antirheumatic drugs (bDMARDs) and Janus kinase inhibitors (iJAK) during the COVID-19 pandemic requires a balanced approach and tight monitoring of the patients.The aim of the study was to study the effect of bDMARDs and iJAK inhibitors on the condition of patients with rheumatoid arthritis (RA), taking the patients reported outcomes, as well as the incidence of COVID-19 in these patients.Materials and methods. A telephone survey was conducted of 254 patients with RA (average age – 49.8±13.7 years; 64.4% of patients are positive for rheumatoid factor; women – 83.5%; DAS28 score – 5.4±1.6 points), who in the period from January 2020 to June 2021 were prescribed bDMARDs or iJAK for the first time: 148 (58.3%) – rituximab; 57 (22.4%) – tumor necrosis factor α inhibitors; 20 (7.9%) – iJAK; 17 (6.7%) – interleukin 6 inhibitors; 12 (4.7%) – abatacept.Results. At the time of the survey, 204 (80.3%) patients continued taking prescribed medications. The main reason for the interruption of treatment was administrative problems. Synthetic DMARDs (mainly methotrexate and leflunomide) were received by 68.0%, glucocorticoids – 45.3%, nonsteroidal anti-inflammatory drugs – 44.5% of respondents. Among patients treated with bDMARDs or iJAK, 68.1% noted «the state of symptoms acceptable to the patient», the absence of frequent joint pain – 65.3%, the absence of increased fatigue – 14.3%. The incidence of COVID-19 and hospitalization associated with this disease did not differ in individuals who continued and stopped using bDMARDs or iJAK: 41.2% and 44.6%, 13.7% and 14.0%, respectively (p=0.80884). There were no statistically significant differences in the incidence of COVID-19 and hospitalization associated with this disease in patients taking various bDMARDs or iJAK.Conclusion. Despite the COVID-19 pandemic, rituximab remains one of the most popular bDMARDs. About a third of patients receiving bDMARDs or iJAK are not satisfied with their condition. More than 40% of patients who received these drugs suffered COVID-19; 14.0% required hospitalization.
Different clinical relevance of anti-citrullinated proteins antibodies in RA patients
Authors: Avdeeva A. S. , Cherkasova M. V. , Nasonov E. L. 
Published: May 2022

Objective – to find a potential relationship between ACPA and disease activity, bone destruction, and ACPAs responses to various therapeutic regimens.Materials and methods. The study included 232 patients with rheumatoid arthritis (RA); 90 patients had early RA; 142 patients had advanced stage of the disease.Results. 77 (85.6%) patients with early RA were high positive for anti-CCP, and 29 (70.7%) patients – high positive for anti-MCV. A positive correlation was found between anti-MCV and DAS28 (r=0.4; p=0.04). As for advanced RA, 78 (80.4%) patients were high positive for anti-CCP, and 70 (79.5%) – for anti-MCV. There was a positive correlation between anti-MCV concentration and SDAI (r=0.4; p=0.02), as well as CDAI (r=0.4; p=0.02). No significant correlations were found between the anti-CCP levels and activity indices, anti-CCP and acute-phase parameters in both early and advanced RA groups. Higher total Sharp scores (96.5 (65.0–122.0)) were found in pts high positive for anti-MCV (n=79), compared to low-positive/negative (n=27) patients (57.0 (31.0–88.0); p<0.05). Anti-MCV levels dropped significantly in pts on rituximab and tocilizumab therapy at weeks 12 and 24 after initiation of treatment, while high anti-CCP concentration persisted throughout the treatment.Conclusion. Anti-MCV levels correlated with inflammatory activity and development of bone destruction, and were decreasing in pts on treatment. Anti-CCP was less responsive, showed minor changes during treatment, therefore its’ thorough monitoring was not feasible.
Utility of Vaginal pH as Point of Care Test for Detection of Bacterial Vaginosis
Authors: Metgud Shridevi , Gangigute Spurthi , Metgud Sharada 
Published: May 2022

Abstract

Background & objectives: Bacterial vaginosis (BV) is a Reproductive tract infection (RTI) among young sexually active women with high prevalence. It is associated with complications related to pregnancy and an increased risk of acquiring STDs. This poses a need for cost-effective detection of BV in low resource settings. Hence, we propose to study the utility of vaginal pH determination for the detection of BV.

Material & Methods: This is a single center, 1 year cross-sectional study. Swabs were collected from 250 non-pregnant women attending the out-patient department of Obstetrics and Gynecology with vaginal discharge as a predominant symptom with or without backache and abdominal pain. Vaginal pH determination, Gram stain, wet mount, Whiff test, and Amsel’s criteria were used for BV detection.

Results: 250 study participants with vaginal discharge suggestive of BV were analyzed. Vaginal pH was significantly higher in women with BV with the mean pH being 6.2. Vaginal pH >4.5 had a sensitivity of 85% and specificity of 66% to detect BV. The Whiff test had the least sensitivity. Clue cells and Amsel’s criteria of ≥ 3 were significant for BV. A combination of pH and Whiff test performed better had high sensitivity and specificity.

Conclusions: A combination of pH determination and the Whiff test serves as a low-cost alternative in resource-poor settings for detection of BV. Though Clue cells and Amsel’s criteria ≥ 3 were most sensitive and specific, they cannot be used in low resource settings. Vaginal pH alone can be used to detect BV in areas of low prevalence.
Histomorphological spectrum of Phyllodes Tumours: A Restrospective
Study
Authors: Singhal Udita , Mahapatra Qury , Kumar Uma , Nanda Annu , Jain Pooja , Trivedi Shalini 
Published: May 2022

Abstract

Introduction: Phyllodes tumours are rare fibroepithelial lesions of breast. Clinical examination, ultrasound, cytology and histopathology are the mainstay of the diagnosis. The present research was undertaken with the aim of studying the clinicopathological features of Phyllodes tumour reported in the past seven years in a Delhi government hospital.

Method: A retrospective study of phyllodes tumour was carried out in females from 225 diagnosed cases of breast lesion reported in the pathology department of a government hospital in Delhi during the period of January 2013 to December2019. All the relevant history, findings of clinical examination and investigations performed were assessed from files of the patient.

Results: Out of 225 cases of breast lesions reported in the pathology department 8 tumours were reported as phyllodes in the study period. The most common affected age group was 41- 50yrs. 5 (62.5 %) of 8 tumours were benign,2 (25) %) were borderline and only 1 was malignant. The tumour size was 15mm to 200mm. All the 8 cases (100%) presented with breast lump; 3 cases (30%) complained of pain in the lump. 2 cases developed ulceration and Peau D’ orange and in 1 case typical nipple retraction was seen. FNAC was done in 5 patients. No preoperative investigations were done in 2cases.

Conclusion: Phyllodes tumour is a rare neoplasm of the breast. Histopathology plays an important role in differentiating it from fibroadenoma. Strict histologic assessment is definitely required for the diagnosis of the PT and for its treatment and management
A proposed scoring system for fast triage of COVID 19 patients using basic clinical parameters: Simple Clinical Parameter (SCIP) Score
Authors: Chandel Satish , Rai Geeta , Tayal Vandana , Rai Niket , Singhal Shubha , Sharma Parag 
Published: May 2022

Abstract

Introduction
: Globally healthcare systems are jeopardized due to the COVID-19 pandemic. A fast and simple triage is very important for effective utilization of health care resources. We propose a new tool is for severity assessment of patients at the initial point of care.

Objective: To propose a scoring method for fast triage of COVID 19 patients in predicting the level of care required by the patient

Methods: The SCIP score is for patients who have been tested positive for COVID-19. This scoring system is useful to segregate the patients into different level of care based on values of clinical parameters like Pulse rate (PR), Respiratory rate (RR) and arterial blood oxygen saturation. The risk score ranges from 1 to 10. Lower the score more severe is the disease and hence more intense care is warranted.
Result: Preliminary observation of SCIP scoring criteria is based on ten patients. On retrospective analysis it was observed that the level of care required by the patients was in correspondence with the score obtained by the SCIP formula.

Conclusion: SCIP scoring system is an easy and rapid tool which may be helpful in early detection of severity and taking fast decision in the time of crisis due to COVID 19. Validation in more number of patients is required to establish the findings.
Computed Tomography (CT)guided Fine Needle Aspiration Cytology of Intrathoracic Lesions
Authors: Pulluri Sridhar , Madire Ramulu 
Published: May 2022

Abstract

B
ackground: Diagnosis of intrathoracic masses is a difficult challenge for clinicians. The compact anatomical arrangement of the mediastinum with diverse pathologies is usually encountered. The present study was done to determine the efficiency of computed tomography (CT) guided Fine-Needle Aspiration Cytology (FNAC) in the evaluation of various thoracic mass lesions

Methods
: A total of n=46 patients presenting as intrathoracic mass lesions, confirmed on contrast-enhanced CT, were included in the study. A commercially available CT (Ingenuity 128 slices, Philips) was used for biopsy. All patients were subjected to detailed clinical history and physical examination. Investigations: Complete blood count, Erythrocyte sedimentation rate, bleeding time, clotting time, Prothrombin time, Activated partial thromboplastin time, HIV and HbsAg, Chest X-ray postero Anterior view, and Lateral view done in all cases. Chest X-ray AP view and Ultrasound was done wherever needed. Plain and contrast CT was done in all cases before FNAC.

Results: The positive diagnostic yield in our study is noted in 45 of the 46 patients(97.82%); the positive yield for malignancy was 89.13% (41 of 46 patients), benign in8.69 % (4/46), and undiagnosed in 1/46 (2.17%). Out of 46, 40(86.96%) were parenchymal lesions and 6(13.04%) were mediastinal lesions. Out of 40 parenchymal lesions, 38/40(95%) were malignant, which consisted of 55.3% Squamous cell carcinoma, 28.9% Adenocarcinoma.

Conclusion: FNAC is useful for obtaining samples for the diagnosis of focal pulmonary infections, even in immunocompromised patients, and planning appropriate chemotherapy options in lung cancer and metastatic lesions.CT-guided FNAC is an initial approach for the diagnosis of small pulmonary nodules of less than 20mm, aiding in early diagnosis and treatment interventions improving prognosis.
Scheduling in IaaS Cloud Computing Environment using Sailfish Optimization Algorithm
Authors: Kumar Manoj , Suman Suman 
Published: May 2022

Due to the exceptional benefits of cloud computing, it has magnetized IT leaders and entrepreneurs at all levels. The cloud's popularity is attributed to various technologies like the Internet of Things (IoT), mobile computing, Fog, etc. Scheduling in cloud computing is still a challenging issue due to its NP-Hard nature. In recent years, many techniques have been proposed for optimal scheduling that can subsequently improve efficient Quality of Service (QoS). This paper has developed and analysed a novel Sailfish Optimization-based Scheduling Algorithm. SOSA is implemented on 2 data-sets; a real-world data-set from NASA workload, and a randomly generated data-set. SOSA exhibited 13.71 and 7.81 % average performance improvement in makespan compared to GA and PSO and 11.30 and 30.78 % average improvement in execution cost compared to GA and PSO.
HIGHLIGHTS

Scheduling in Cloud computing has NP -Hard Problem nature that may degrades Quality of Service to users
A Novel Sailfish optimization based scheduling algorithm (SOSA) technique is proposed to increase Quality of Service in terms of Makespan and Execution Cost
Simulation has been performed in CloudSim on NASA workload and synthetic dataset
Proposed SOSA techniques proves to be more effective to provide Quality of Service and proves to be more significant as compared to GA and PSO
Pitting Propagation Behavior on Low Alloy AISI 4130 (UNS G41300) Steel Exposed to Various Alkali and Alkaline Earth Metal Chlorides
Authors: Demarest Charles , Asmussen R. Matthew , Scully John R. 
Published: May 2022

This study examined pit propagation to elucidate whether alkali and alkaline earth metal chloride salts such as RbCl affect pitting in some manner previously not expected compared to NaCl. Pit propagation studies were conducted on low alloy steel using one-dimensional (1D) pit method over pit depths from 300 µm to 1,000 µm. Linear sweep voltammetry and electrochemical impedance spectroscopy on planar 4130 electrodes over a range of Cl− concentrations revealed no differences in impedance, open circuit, corrosion potential (Ecorr), passive current density (ipass), and pitting potential (Epit) as a function of salt type. In the case of 1D pits evaluated during fast downward scan rates, the saturation potential (Esat) varied as a function of salt type and at shallow pit depths. Mass transported limited current density also varied with salt type in shallow pits when other alkali metal and alkaline metal cations where present. The potential (Esurf) of activated pit surfaces reached Ecorr prior to establishing a condition where the pit electrolyte surface concentration (Csurf) was less than the critical concentration for active acidified pitting (Csurf &lt; Ccrit) in this marginally passivating steel. For various Esurf and pit current density (ipit) combinations at constant Csurf where Ccrit &lt; Csurf &lt; Csat, E-log(i) plots were constructed using the method of Li Tianshu to unmask IR ohmic voltage corrected Tafel plots at fixed pit solution concentrations. Under these conditions, the influence of salt identity on charge-transfer-controlled kinetics was re-examined and slight differences in Tafel behavior were found. Differences in metal cations have little effect on passive planar electrodes and only affect pit propagation stage in shallow pits.
Preferencias tróficas y bioecología de Pimelodus sp. “Gúnguma” en la cuenca media del río Atrato, Colombia
Authors: Cuesta Ríos Eric Yair , Cuesta Incel Marleny 
Published: May 2022

Objetivo: Se realizaron colectas en la ciénaga El Tigre (cuenca media del río Atrato, Colombia) para analizar las preferencias tróficas y bioecología de Pimelodus sp. (Gúnguma). Metodología: Se determinaron los hábitos alimenticios mediante el índice de importancia relativa (IIR) y el coeficiente de vacuidad, los cuales permitieron comprobar que esta especie es omnívora, con preferencias hacia los macroinvertebrados, acompañados de elementos vegetales.En este mismo sentido, se determinó que en mayo (34%) y en junio (34%) fueron los meses con mayor número de estómagos vacíos, esto producto de las lluvias que aumentan el caudal de la ciénaga y se dispersa el alimento de la especie. Mediante regresión lineal se analizaron las relaciones de longitud peso por especie, calculando los valores de a y b de la ecuación W=aLb. Resultados: El factor de condición registró un promedio de 0,94 (±1,31), donde sus valores oscilaron entre 0,82 (±1,36) y 1,06 (±1,18), lo que evidencia el buen estado fisiológico en que se encuentra la especie. La relación longitud peso registró un promedio de 1,18 (±0,17), con un grado de asociación fuerte entre las variables (r=0,99), presentando un crecimiento de tipo alométrico para el Gúnguma, indicando que el incremento en talla es más rápido que el incremento en peso. Conclusiones: Pimelodus sp. es una especie de hábitos omnívoros con preferencia en su dieta por macroinvertebrados, semillas y frutas.
Relatos sobre Covid-19 de profesionales de la salud en un hospital
Authors: Pedace Mariana L. , Usandivaras Ignacio M. , Gothelf Elizabeth E. , Cortines María Cristina , Tarnofky Diana I. , Ramos Mariana , Barrera Liliana 
Published: May 2022

Introducción: la pandemia de COVID-19 impone a los profesionales de la salud: altas exigencias y modificaciones en el modo de vincularse con pacientes, pares y familiares. Estos cambios implican consecuencias emocionales tales como el incremento del nivel de estrés y síntomas de ansiedad y de depresión.
Objetivo: describir un proyecto interdisciplinario creado bajo el modelo de la Medicina Narrativa dirigido a habilitar el relato de la experiencia de profesionales de la salud pertenecientes a un hospital general privado de alta complejidad de la ciudad de Buenos Aires durante la pandemia de COVID-19.
Metodología: se creó una lista de correo y se convocó a profesionales del hospital a realizar una producción escrita, oral o gráfica que represente su experiencia durante la pandemia. Luego, el material recibido se envió a la misma lista de distribución con frecuencia semanal. En cada correo se renovó la invitación a narrar lo vivido o comentar los relatos de otros.
Resultados: en el transcurso de siete semanas se recibieron diez producciones individuales: ocho textos, un audio y un gráfico. Los principales temas tratados pudieron agruparse en tres ejes: sala COVID, comunidad y telemedicina. Los autores fueron profesionales de Medicina, Enfermería, Psicología y de Puericultura.
Conclusión: desarrollamos un proyecto bajo el modelo de la Medicina Narrativa que permitió a profesionales narrar su experiencia durante la pandemia de COVID-19, habilitando la posibilidad de poner en palabras lo vivido, reflexionar sobre modelos de actuación y elaborar el desgaste emocional generado por el contacto permanente con el dolor y el sufrimiento.
ASSESSMENT OF THE CONTRIBUTION OF DIGITALIZATION TO ECONOMIC GROWTH
Authors: Гельманова З.С. , Мажитова С.К. , Gelmanova Z. , Mazhitova S. 
Published: May 2022

В статье рассматривается формирование и развитие научных представлений о процессе цифровизации. Сформулирована собственная трактовка определения цифровизации и цифровой экономики. Представлен инструмент повышения эффективности деятельности фирмы. Уточнена сущность понятия «цифровая трансформация» и выявлены различия между автоматизированными и цифровыми процессами. Показана взаимосвязь автоматизации, цифровизации и цифровой трансформации.В работе сформулирована модель элементов цифровой трансформации фирмы, показана блок – схема проведения подготовки к цифровой трансформации, представлена модель цифровой трансформации в виде матрицы, дана их краткая характеристика.Для оценки вклада цифровизации и цифровых компаний в экономический рост, оценки общего уровня развития цифровизации, в настоящий момент, наиболее объективным подходом выступает модель статистического измерения цифровой экономики, предложенной и используемой Национальным исследовательским университетом «Высшая школа экономики» (НИУ ВШЭ). Модель основана на подходах, используемых Евростатом и Организацией экономического сотрудничества и развития (ОЭСР).
The article discusses the formation and development of scientific ideas about the process of digitalization. The author formulates his own interpretation of the definition of digitalization and the digital economy. A tool for improving the efficiency of the company's activities is presented. The essence of the concept of "digital transformation" is clarified and the differences between automated and digital processes are revealed. The relationship between automation, digitalization and digital transformation is shown.The paper formulates a model of the elements of a company's digital transformation, shows a flowchart for preparing for digital transformation, presents a model of digital transformation in the form of a matrix, and gives a brief description of them.To assess the contribution of digitalization and digital companies to economic growth, to assess the overall level of digitalization development at the moment the most objective approach is the model of statistical measurement of the digital economy, proposed and used by the National Research University "High School of Economics" (HSE). The model is based on the approaches used by Eurostat and the Organization for Economic Cooperation and Development (OECD).