bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficiency of labor immigration regulations: approaches and methods of assessment
Authors: Popova Svetlana Mikhailovna , Yanik Andrey Aleksandrovich 
Published: November 2022

A number of modern approaches and methods for assessing the efficiency of labor immigration regulations are considered. The efficiency of immigration policy we understand as the ability of regulatory mechanisms to ensure timely, differentiated, and orderly attraction of desirable migrants to the country's economy in such a way that this resource brings maximum benefit in solving current problems of socio-economic development and does not threaten national security. Sources for research: an array of official documents of Russia, EU countries, the ILO in the field of migration regulation (strategies, reports, results of evaluation procedures, statistics), and relevant scientific literature. General scientific and comparative methods are used in the work. Two polar approaches are distinguished in the international literature: "bureaucratic" (based on the principles of project management and associated with the development of procedures for external independent evaluation of specific measures (projects) of migration policy) and "academic" (search for common theoretical models and universal methods that allow on a single basis to compare the results of migration regulation in different countries). The Russian literature also identifies two clusters that differ in priority criteria for evaluating effectiveness: (1) assessment of the adequacy of migration policy to the economic interests of Russia (taking into account the demands of regional labor markets), (2) the ability to guarantee the interests of public safety and strengthening the unity of the multinational people of Russia. The combination of competing criteria can give a more comprehensive idea of the effectiveness of migration policy, but the practical implementation of the approach is still difficult.
Determinant of self-management in chronic non-communicable disease among elderly
Authors: Harisa Akbar , Arfan Andi Fadillah , Ramadhani Wafiq Aulia , Pahruddin M. Nabil Sakti , Yodang Yodang 
Published: November 2022

Chronic non-communicable diseases have become a health concern in the health care system worldwide, especially in older people. Managing the disease was crucial to improving the quality of life among those older people. This study aims to identify self-management among older people with chronic non-communicable diseases. A cross-sectional study method was conducted in two primary healthcare centers. The respondents were recruited using accidental sampling, and 40 older people participated. The socio-demographics, lifestyle, and self-management were extracted by using paper-based questionnaires. All socio-demographic and lifestyle data statistically show no significant impact on the self-management of chronic non-communicable diseases among older people. Predominantly participants were old-old category (55%), women (62.5), the middle level of education (50%), household (42.5%), married (67.5%), consuming salted fish (80%), salted egg (50%). Since the study result is statistically insignificant, the large sample size may be needed to increase the study result.
Keywords: Non-communicable disease; community nursing; elderly care; quality of life; self-management
Pembelajaran STAD Pasca Pandemi COVID-19 dan Dampaknya Terhadap Sikap, Keterampilan, dan Hasil Belajar Siswa Sekolah Menengah Kejuruan
Authors: Ismunandar Denni , Andriani Mela , Sudirman Sudirman , Taufan Mochammad 
Published: November 2022

Pada akhir tahun 2021, Covid - 19 telah melandai dan sekolah mulai memberlakukan pembelajaran secara blended learning. Tujuan penelitian ini adalah mengetahui pengaruh sikap dan keterampilan siswa terhadap hasil belajar siswa pasca pandemi Covid-19 menggunakan metode Student Teams Achievement Divisions (STAD). Subyek penelitian ini adalah salah satu SMK Negeri di Indramayu kelas XII Jurusan TKJ. Pengambilan sample menggunakan teknik purposive sampling yang dilakukan oleh guru. Sample pada penelitian ini adalah siswa jurusan TKJ yang terdiri dari 33 siswa. Pengambilan data dilakukan melalui tes dan peneliti menggunakan persamaan regresi linier dua prediktor untuk mencari besar pengaruh sikap dan keterampilan terhadap hasil belajar siswa. Hasil analisis regresi adalah dengan . Artinya sikap dan keterampilan siswa bersama – sama mempengaruhi hasil belajar siswa sebesar 17,2%. Masih ada faktor lain sebesar 82,8% yang mempengaruhi hasil belajar siswa
From an Intangible Idea of a Fashion Collection to an Intangible Digital Future. A Yannis Tseklenis Vase Look Dress
Authors: Moyssi Noly , Georgiou Ropertos , Avgousti Avgoustinos 
Published: November 2022

Fashion is defined as changing styles in dress and appearance, adopted by a group of people in a specific place and time; it also relates to the market economy. Roland Gérard Barthes (1915–1980) noted that the annual change in dress code means that the consumer has a new code to learn from year to year, and in this process of learning, fashion magazines have an important role to play. Fashion magazines fulfil this role by combining image with text.
Since the 1950s, developing countries with a surplus of unskilled labour were in an advantageous position to attract investments for industrial units that would produce cheap products, as the cheap labour cost of the work hour made them extremely competitive. Developed countries with skilled workforces could only compete with the production of items requiring know-how and high-tech infrastructure if they could justify higher labour costs. These countries, however, had no choice but to import mass-produced goods, produced in developing countries with cheaper labour, such as Greece.
Dyslexia biomarker detection with Quantitative electroencephalography (QEEG) data in children: Feasibility, Acceptability, Economic impact, Pilot Study and Survey Results
Authors: Eroglu Gunet , Köprülü Mertali , Karabacak Berdan 
Published: November 2022

INTRODUCTION
Dyslexia awareness is not high in societies. Although 5-17% of the population is thought to be dyslexic in every global society, only 0.05 % of the population gets a formal diagnosis in Turkey. The financial situation of families of children with dyslexia is not enough to get an early diagnosis and investigate intensive remedial opportunities. Mobile apps have been used to diagnose health conditions in recent years. Worldwide solutions for dyslexia do not exist as the solutions were language-dependent. We need an easily reachable, affordable, language-independent, and worldwide acceptable biomarker detection app for dyslexia at schools because it potentially helps to prevent severe consequences through an early diagnosis that helps provide early intervention. No other research assessed the feasibility and acceptability of using this mobile app to detect dyslexia at home or school. Here we present a dyslexia biomarker detection app based on Z-scored Quantitative Electroencephalogram (QEEG) data that can be used at home or school and has accomplished a high accuracy rate in diagnosing dyslexia. The mobile app can be used at home by parents or teachers at school.

METHODS
We have collected data from 207 children (96 of them have dyslexia, 111 of them are typically developing) between 7-10 years old for 40 sessions on average. The data consists of the eyes-open resting state 2-minute QEEG data from 14-channels.

RESULTS
Using the Artificial Neural Network (ANN) machine learning method, children with dyslexia/ typically developing children (TDC) classification has been done with a high accuracy rate (98.8%). ANN yields the highest accuracy results with standardized QEEG data in the literature. A survey is created to assess the dyslexia biomarker detection app’s feasibility, acceptability, and economic impact. The results have shown that the biomarker detection app is found feasible and acceptable by families, however, it is found expensive to use at home as it includes the costly electroencephalography (EEG) headset.

CONCLUSION
In order for this biomarker detection method to be used extensively at home, EEG headset prices should become more affordable or this dyslexia biomarker detection method can be used at schools.
Does Tocovid, a Tocotrienol-rich Vitamin E, Mitigate Postoperative Atrial Fibrillation after Coronary Artery Bypass Grafting (CABG) Surgery? A Single-Centre Double-blind Randomised Controlled Trial
Authors: Musa Ahmad Farouk , Dillon Jeswant , Ezani Md Taib Mohamed , Mohamed Yunus Alwi , Rais Sanusi Abdul , Nazeri Nordin Mohd , A. Smith Julian 
Published: November 2022

OBJECTIVE: To determine whether tocotrienol-rich Tocovid has any effect in reducing the incidence of postoperative atrial fibrillation (POAF), mortality and morbidity, length of Cardiac Intensive Care Unit (CICU), High Dependency Unit (HDU) and total hospital stay among post coronary artery bypass grafting (CABG) patients; and in improving their quality of life (QOL).

METHODS: A single-centre prospective randomised controlled trial was conducted at the National Heart Institute, Kuala Lumpur. The treatment group received Tocovid capsules while the control group received placebo containing palm superolein.

RESULTS: The recruitment of patients started in January 2019 and reached the target population of 250 patients in December 2021. 95.6% of patients completed the study with a 4.4% attrition rate. No statistically significant difference was observed between the age group, gender, race, EuroSCORE II status, body mass index, NYHA class, left or right atrial size, ejection fraction, preoperative medications and premorbid history (except hypercholesterolaemia). There was also no difference in cardiopulmonary bypass time, aortic cross-clamp time, or number of anastomoses. In terms of outcomes, we noted a significant difference in the occurrence of pleural effusion and a longer CICU stay (_p_=0.04) among the placebo groups. The probability of occurrence of POAF was 36.4% with no difference between the two groups and this was reflected in the low blood levels of tocotrienols at day one post-surgery whence the median time for POAF development was 47-hours post-CABG. The quality of life as measured by the 36-Item Short Form Survey (SF-36) and Nottingham Health Profile (NHP) did not show any significant difference except in role physical and role emotional on SF-36 and sleep quality on NHP.

CONCLUSION: POAF was not mitigated by Tocovid presumably from low tocotrienol level post-surgery; however, the CICU stay was shortened with reduced pleural effusion, and an improvement in the physical and emotional state with better sleep quality.
Pilóta nélküli légi járművek kooperatív irányítása
Authors: Szabolcsi Róbert 
Published: November 2022

Az autonóm járművek, így többek között a pilóta nélküli légi járművek (UAV) irányításának egyik fontos területe a járművek kooperatív irányítása. A kooperatív irányítás során megvalósítandó célkitűzés a járművek mozgásának összehangolása egy előre megadott közös, globális cél megvalósítása érdekében. Ilyen cél lehet például az UAV eljuttatása megadott időben egy előre megadott helyre (például légi utántöltés, légi kötelék kialakítása, eljutás a megfigyelési helyre, eljutás a felderítés helyére, eljutás a harci bevetés helyére, eljutás megadott határszakaszra stb.). A szerző célja bemutatni néhány lehetséges UAV bevetési forgatókönyvet és repülési feladatot, és az ezeket megvalósító irányításokat és irányítási rendszerek alapkoncepcióit.
Співробітництво України та Великої Британії в умовах російсько-української війни
Authors: Стужук Ю. 
Published: November 2022

В результаті повномасштабного вторгнення, путінська Росія кинула виклик усьому колективному Заходу, погрожуючи встановити свій контроль над ними, щоб у свою чергу поставити на порядок денний питання перерозподілу сфер впливу. Майбутній розвиток демократичної Європи в її широкому форматі залежить від збереження державності України як важливого та невід’ємного її елемента і суб’єкта, що як видається однією з перших остаточно усвідомила політична еліта Великобританії.
Мета статті полягає у комплексному та всебічному дослідженні співробітництва України та Великобританії в умовах російсько-української війни.
В умовах сьогодення, Велика Британія має чітку позицію щодо підтримки територіальної цілісності та суверенітету України, зокрема у рамках міжнародних організацій (Організація Об’єднаних Націй, Організація з безпеки і співробітництва в Європі та Рада Європи). Велика Британія, являючись постійним членом Ради Безпеки ООН, регулярно виступає на підтримку української державності. Систематично робляться заяви на захист судноплавства в Чорному морі, щодо анексії Автономної республіки Крим чи катастрофи рейсу MH17, незаконних дій РФ та загострення на Донбасі, політичних в’язнів.
У процесі набуття досвіду українсько-британської військово-політичної співпраці сформувалися такі його головні напрями:
діалог штабів усіх родів і видів збройних сил із метою координації позицій, інституційного реформування української армії й досягнення сумісності;
проведення спільних навчань (“Козацький степ”, “Козацький експрес”, “Козацька булава”) за участі військових підрозділів інших держав НАТО;
спільна участь у миротворчих місіях (наприклад, в Іраку);
організація курсів перепідготовки для українських військових із вивчення англійської мови, права та інформаційних технологій, а з 2015 р. розгорнуто навчально-тренувальну місію “Orbital”, через яку вже пройшли 22 тис. осіб.
Paisaje y energías renovables. Notas para un debate
Authors: Alomar Garau Gabriel 
Published: November 2022

Las tensiones paisajísticas y en definitiva estéticas creadas por la implantación territorial de las renovables, ponen de relieve algo relevante: nuestra época se ha tornado enormente sensible a las afectaciones visuales de las nuevas infraestructuras, lo que a su vez significa que somos una sociedad enteramente “paisajística”, es decir sensible hacia la belleza que sólo ahora atribuimos a ciertos espacios, especialmente los agrarios pero también los improductivos. Se ha interiorizado el aprecio irrenunciable por ciertos lugares, apreciándolos por su valor estético, identitario o simbólico. La necesidad de la transición hacia las renovables nos hace ver la necesidad de encontrar el lugar –el mejor lugar– donde ubicarlas.
A new machine learning-based prediction model for subtype diagnosis in primary aldosteronism
Authors: Shi Shaomin , Tian Yuan , Ren Yong , Li Qing’an , Li Luhong , Yu Ming , Wang Jingzhong , Gao Ling , Xu Shaoyong 
Published: November 2022

IntroductionUnilateral primary aldosteronism (UPA) and bilateral primary aldosteronism (BPA) are the two subtypes of PA. Discriminating UPA from BPA is of great significance. Although adrenal venous sampling (AVS) is the gold standard for diagnosis, it has shortcomings. Thus, improved methods are needed.MethodsThe original data were extracted from the public database “Dryad”. Ten parameters were included to develop prediction models for PA subtype diagnosis using machine learning technology. Moreover, the optimal model was chose and validated in an external dataset.ResultsIn the modeling dataset, 165 patients (71 UPA, 94 BPA) were included, while in the external dataset, 43 consecutive patients (20 UPA, 23 BPA) were included. The ten parameters utilized in the prediction model include age, sex, systolic and diastolic blood pressure, aldosterone to renin ratio (ARR), serum potassium, ARR after 50 mg captopril challenge test (CCT), primary aldosterone concentration (PAC) after saline infusion test (SIT), PAC reduction rate after SIT, and number of types of antihypertensive agents at diagnosis. The accuracy, sensitivity, specificity, F1 score, and AUC for the optimal model using the random forest classifier were 90.0%, 81.8%, 96.4%, 0.878, and 0.938, respectively, in the testing dataset and 81.4%, 90.0%, 73.9%, 0.818 and 0.887, respectively, in the validating external dataset. The most important variables contributing to the prediction model were PAC after SIT, ARR, and ARR after CCT.DiscussionWe developed a machine learning-based predictive model for PA subtype diagnosis based on ten clinical parameters without CT imaging. In the future, artificial intelligence-based prediction models might become a robust prediction tool for PA subtype diagnosis, thereby, might reducing at least some of the requests for CT or AVS and assisting clinical decision-making.
Understanding of groundwater evolution through chemical and age dating information in the Yongding River alluvial fan in Beijing
Authors: Liu Kai , Qiao Xiaojuan , Wang Shanshan , Sun Ying 
Published: November 2022

Groundwater plays important roles in human community development and the urbanization process as the results of global environmental change and rapid population growth. A clear understanding of the vertical and horizontal spatial distribution characteristics of groundwater and sediment is the premise of efficient groundwater resource management and utilization in alluvial plains. To explore the evolution process of groundwater and the distribution of sediment in the Yongding River (YDR) alluvial fan, a typical profile from Mentougou to Fengheying was chosen to conduct an extensive hydrogeological investigation with multiple hydrochemical, isotopic, and age dating analyses, which represents one of the most typical hydrogeological units in the YDR alluvial fan. The analysis results show that (i) along the profile, the water’s chemistry type gradually changes from HCO3-Ca·Mg to HCO3-Na. The contents of coarse grain gradually decrease while fine particles regularly increase. Also, a similar evolution trend is found in the vertical direction. (ii) The annual renewable rate of groundwater is &gt; 10% in the upper fan, 2%–8% nearby Daxing, and &lt; 2% in Fengheying. (iii) In the proximal fan area, the average flow velocity of the single and double layer is about 65 m yr−1 and of approximately 18.9 m yr−1. From the mid fan to distal fan, the value of velocity and hydraulic conductivity decreases from 12.4 m yr−1 to 3.75 m yr−1 and from 8.54 m yr−1 to 0.64 m yr−1, respectively. (iv) The 14C analysis results indicate that the age of shallow and deep groundwater ranges from 5a to 60a and from 4000a to 12000a, respectively. The groundwater age increases with depth in the vertical direction and increases from northwest to southeast along in the alluvial fan in the horizontal direction. Understanding the evolution process of sediment and hydrochemistry in the YDR alluvial fan provides a valuable reference for groundwater resource development, utilization, and pollution prevention in the alluvial fan.
Construction of cuproptosis-related gene signature to predict the prognosis and immunotherapy efficacy of patients with bladder cancer through bioinformatics analysis and experimental validation
Authors: Liu Zijian , Zhu Fubin , Zhang Pu , Qian Bei , Liu Weihui , Xiao Yajun , Chen Nianyong , He Qingliu , Xiao Jianghong 
Published: November 2022

Background: A new form of cell death, copper-dependent cell death (termed cuproptosis), was illustrated in a recent scientific study. However, the biological function or prognostic value of cuproptosis regulators in bladder cancer (BLCA) remains unknown.Materials and Methods: Sequencing data obtained from BLCA samples in TCGA and GEO databases were preprocessed for analysis. Biological function and immune cell infiltration levels evaluated by gene set variation analysis (GSVA) were employed to calculate enrichment scores. Iteration least absolute shrinkage and selection operator (LASSO) and COX regression model were employed to select feature genes and construct a novel cuproptosis-related (CR) score signature. The genomics of drug sensitivity in cancer (GDSC) and tumor immune dysfunction and exclusion (TIDE) analysis were used to predict the chemotherapy and immunotherapy efficacy for BLCA patients. The relative expression of the genes involved in the signature was also verified by real-time quantitative PCR (qRT-PCR) in cell lines and tissues.Results: Expression abundance and the prognostic value of cuproptosis regulators proved that cuproptosis might play a vital part in the carcinogenesis of BLCA. GSVA revealed that cuproptosis regulators might be associated with metabolism and metastasis-related pathways such as TGF-β, protein secretion, oxidative Phosphorylation, MYC targets, MTORC1, and adipogenesis pathways. CR scores could predict the prognosis and evaluate the chemotherapy and immunotherapy efficacies of BLCA. CR scores were positively correlated with EMT, MYC, MTORC1, HEDGEHOG, and E2F signaling pathways; meanwhile, they were negatively correlated with several immune cell infiltration levels such as CD8+ T cells, γδT cells, and activated dendritic cells. Several GEO datasets were used to validate the power of prognostic prediction, and a nomogram was also established for clinical use. The expressions of DDX10, RBM34, and RPL17 were significantly higher in BLCA cell lines and tissues in comparison with those in the corresponding normal controls.Conclusion: Cuproptosis might play an essential role in the progression of BLCA. CR scores could be helpful in the investigation of prognostic prediction and therapeutic efficacy and could make contributions to further studies in BLCA.
Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells
Authors: Comez Dehan , Glenn Jacqueline , Anbuhl Stephanie M. , Heukers Raimond , Smit Martine J. , Hill Stephen J. , Kilpatrick Laura E. 
Published: November 2022

IntroductionThe Epidermal Growth Factor Receptor is a member of the Erb receptor tyrosine kinase family. It binds several ligands including EGF, betacellulin (BTC) and TGF-α, controls cellular proliferation and invasion and is overexpressed in various cancer types. Nanobodies (VHHs) are the antigen binding fragments of heavy chain only camelid antibodies. In this paper we used NanoBRET to compare the binding characteristics of fluorescent EGF or two distinct fluorescently labelled EGFR directed nanobodies (Q44c and Q86c) to full length EGFR.MethodsLiving HEK293T cells were stably transfected with N terminal NLuc tagged EGFR. NanoBRET saturation, displacement or kinetics experiments were then performed using fluorescently labelled EGF ligands (EGF-AF488 or EGF-AF647) or fluorescently labelled EGFR targeting nanobodies (Q44c-HL488 and Q86c-HL488).ResultsThese data revealed that the EGFR nanobody Q44c was able to inhibit EGF binding to full length EGFR, while Q86c was able to recognise agonist bound EGFR and act as a conformational sensor. The specific binding of fluorescent Q44c-HL488 and EGF-AF488 was inhibited by a range of EGFR ligands (EGF&gt; BTC&gt;TGF-α).DiscussionEGFR targeting nanobodies are powerful tools for studying the role of the EGFR in health and disease and allow real time quantification of ligand binding and distinct ligand induced conformational changes.