bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Relationship between Health Locus of Control and Health Behaviors: A Systematic Review
Authors: Dogonchi Mitra , Mohammadzadeh Fatemeh , Moshki Mahdi 
Published: September 2022

Introduction:
Health locus of control is recognized as a factor affecting the development and promotion of health behaviors. The present study aimed to investigate the relationship between health locus of control and health behaviors.

Methods:
This systematic review was conducted by searching several databases including PubMed, Science Direct, Web of Science, Google Scholar, and Scopus from early April to early May 2021 using the keywords Health Locus of Control and Health Behaviors.

Results:
Out of the 1099 articles retrieved after the screening, 18 articles met the criteria for further analysis. A review of the studies showed that those who firmly believed in internal health control were more likely to engage in health behaviors.

Conclusion:
In line with the findings of this study, it is essential to focus on people's beliefs about the influence of internal factors and increase awareness about people's abilities to promote their health behaviors.
Dietary enrichment with crude protein content and feed additives (Bacillus spp. and yeast strains) improves growth performance, survival and circulating hemocytes in juvenile White shrimp, Litopenaeus vannamei
Authors: Morales-Cristóbal Yenni , Cortés-Jacinto Edilmar , Saucedo Pedro , Méndez-Martínez Yuniel , Ledea-Rodríguez José L. , Guzmán-Murillo María A. , Sánchez-Ortiz Ana C. , Aguirre-Guzmán Gabriel , Cadena-Roa Marco , Campa-Córdova Angel I. 
Published: September 2022

In this study the enrichment dietary effect with different crude protein levels (CP) and feed additives on growth, survival, feed conversion ratio (FCR), feed consumption (FC) and total hemocyte count (THC) in juvenile white shrimp Litopenaeus vannamei were evaluated. The study covered two bioassays: in the first one, juveniles were daily fed for 45 days with four experimental diets containing: (1) Control, commercial feed (35% CP); (2) 29% CP; (3) 32% CP; (4) 35% CP. After the 29% CP diet was selected, juveniles in bioassay II were daily fed for 45 days with a single CP diet complemented with probiotics: (1) Control, commercial feed (35% CP); (2) 29% CP; (3) 29% CP + Bacillus mix at 1×106 CFUg–1 feed; and (4) 29% CP + yeast mix at 1×106 CFUg–1 feed. Juvenile shrimp fed with experimental diets gained significantly more weight and increased survival, FCR, FC and THC compared with control diet. However, differences among experimental diets were not significant. In bioassay II, juvenile shrimp fed with experimental diet + feed additives significantly increased survival, FCR, FC and THC compared with control diet. Growth of juveniles significantly increased with 29% CP and 29% CP + yeast mix diets, compared with control group. Complementing the diet with yeast mix showed higher survival and THC of juveniles compared with the other experimental treatments. Different CP levels in shrimp diet improved growth, survival and circulating hemocytes, and addition of mixed yeast as feed additive induced better survival and immune response in juvenile shrimp.
Disentangling genetic risks for metabolic syndrome
Authors: Walree Eva S. van , Jansen Iris E. , Bell Nathaniel Y. , Savage Jeanne E. , Leeuw Christiaan de , Nieuwdorp Max , Sluis Sophie van der , Posthuma Danielle 
Published: September 2022

<p>A quarter of the world’s population is estimated to meet the criteria for metabolic syndrome, a cluster of cardiometabolic risk factors that promote development of coronary artery disease and type II diabetes, leading to increased risk of premature death and significant health costs. In this study we investigate whether the genetics associated with metabolic syndrome components mirror their phenotypic clustering. A multivariate approach that leverages genetic correlations between fasting glucose, high-density lipoprotein cholesterol, systolic blood pressure, triglycerides, and waist circumference was used; which revealed that these genetic correlations are best captured by a genetic one factor model. The common genetic factor genome-wide association study (GWAS) detects 235 associated loci, 174 more than the largest GWAS on metabolic syndrome to date. Of these loci, 53 (22.5%) overlap with loci identified for two or more metabolic syndrome components, indicating that metabolic syndrome is a complex, heterogeneous disorder. Associated loci harbour genes that show increased expression in the brain, especially in GABAergic and dopaminergic neurons. A polygenic risk score drafted from the metabolic syndrome factor GWAS predicts 5.9% of the variance in metabolic syndrome. These results provide mechanistic insights in the genetics of metabolic syndrome and suggestions for drug targets, especially fenofibrate, which has the promise of tackling multiple metabolic syndrome components. </p>
Dynamic Ins2 gene activity defines β-cell maturity states
Authors: Chu Chieh Min Jamie , Modi Honey , Ellis Cara , Krentz Nicole A.J. , Skovsø Søs , Zhao Yiwei Bernie , Cen Haoning , N Noursadeghi , Panzhinskiy Evgeniy , Hu Xiaoke , Dionne Derek A. , Xia Yi Han , Xuan Shouhong , Huising Mark O. , Kieffer Timotyh J. , Lynn Francis C. , Johnson James D. 
Published: September 2022

<p>Transcriptional and functional cellular specialization has been described for insulin-secreting β-cells of the endocrine pancreas. However, it is not clear whether β-cell heterogeneity is stable or reflects dynamic cellular states. We investigated the temporal kinetics of endogenous insulin gene activity using live cell imaging, with complementary experiments employing FACS and single cell RNA sequencing, in β-cells from <em>Ins2</em>GFP knock-in mice. <em>In vivo</em> staining and FACS analysis of islets from <em>Ins2</em>GFP mice confirmed that at a given moment, ~25% of β-cells exhibited significantly higher activity at the evolutionarily conserved insulin gene <em>Ins2</em>. Live cell imaging over days captured <em>Ins2</em> gene activity dynamics in single β-cells. Autocorrelation analysis revealed a subset of oscillating cells, with mean oscillation periods of 17 hours. Increased glucose concentrations stimulated more cells to oscillate and resulted in higher average <em>Ins2</em> gene activity per cell. Single cell RNA sequencing showed that <em>Ins2</em>(GFP)HIGH β-cells were enriched for markers of β-cell maturity. <em>Ins2</em>(GFP)HIGH β-cells were also significantly less viable at all glucose concentrations and in the context of ER stress. Collectively, our results demonstrate that the heterogeneity of insulin production, observed in mouse and human β-cells, can be accounted for by dynamic states of insulin gene activity. </p>
Mechanical Properties of Mineralized Collagen Type I Rat-Tail Tendon Fascicles
Authors: López-Santiago Jeromi G. , Sundaram Paul A. 
Published: September 2022

Type I collagen fibers transmit forces, dissipate energy, and prevent mechanical failure in normal tissues. Mineralization of collagen fibers is proposed to strengthen these structural proteins as a possible therapeutic option for small tears in soft tissues such as cemental tears in periodontal ligaments. In the present study, collagen fascicles extracted from the tail tendons of male Sprague-Dawley rats were tested in a MiniMat tensile tester at different strain rates. The fascicles were previously immersed in SBF to induce mineralization and were maintained in a moist condition during mechanical testing. Mineralization of the fascicles resulted in an increase in the modulus of elasticity and tensile strength with minimal change in percentage elongation to failure. From SEM/EDS, calcium phosphate deposits formed on the fascicles indicating a high probability of intrafibrillar mineralization resulting in the observed improvement in mechanical properties.
Faktor-Faktor yang Mempengaruhi Implementasi SAK EMKM pada UMKM Kota Padang
Authors: Wulandari Dewi , Arza Fefri Indra 
Published: September 2022

This study aims to determine the factors that influence the implementation of SAK EMKM on UMKM in the city of Padang. The data used in this study are primary data sourced from questionnaires given to the owners of UMKM in the city of Padang. Testing is done by using regression. The results showed that simultaneously the independent variables consisting of socialization of SAK EMKM, utilization of information technology, accounting knowledge, education level of the owner, omzet and length of business did not significantly affect the dependent variable, namely the implementation of SAK EMKM. Partially, the socialization of SAK EMKM and the owner's level of education have a positive effect on the implementation of SAK EMKM. While the use of information technology, accounting knowledge, omzet and length of business have no significant effect on the implementation of SAK EMKM in Padang City.
EVDE EĞİTİM PROGRAMININ EISNER’IN EĞİTSEL UZMANLIK VE ELEŞTİRİ MODELİ’NE GÖRE DEĞERLENDİRİLMESİ
Authors: MUTLUER Özgül , GÜROL Mehmet 
Published: September 2022

Bu araştırmada, sağlık durumu nedeniyle okula devam edemeyen öğrencilerin evde eğitimi uygulamalarının Eisner’ın Eğitsel Eleştiri Modeli ile görüşmeler ve ders gözlemleri yapılarak değerlendirilmesi amaçlanmıştır. Programın Eğitsel Eleştiri modeline göre derinlemesine ve bütüncül yaklaşım ile incelenmesinde olgubilim deseninden yararlanılmıştır. Araştırma 2019-2020 eğitim öğretim yılında Yalova il ve ilçelerindeki evde eğitim uygulamaları üzerinde gerçekleştirilmiştir. Araştırmada 4 öğretmen, 4 öğrenci ve velisi, 4 okul yöneticisi ile görüşmeler yapılmış, araştırmacı tarafından 2 öğretmenin dersi gözlemlenmiştir. Araştırma kapsamında verilerin toplanmasında, evde eğitim uygulamalarını gerçekleştiren öğretmen, öğrenci ve velilerin uygulamaya ilişkin görüşlerini almak amacıyla yarı yapılandırılmış görüşmelerden, programın uygulanmasına ilişkin bilgi elde etmek amacıyla ders gözlemlerinden yararlanılmıştır. Araştırma sonucunda, Eisner’ın Eğitsel Uzmanlık ve Eleştiri Modeli’ne göre değerlendirilen Evde Eğitim Programı’nın yürütülmesinde birtakım sorunlarla karşılaşılmaktadır. Bu sorunların başında, öğrencinin sosyal etkileşimden uzak kalması, eğitim ortamındaki araç-gereç eksikliği ve evde eğitim programının yalnızca miğfer dersleri (Hayat Bilgisi, Sosyal Bilgiler, Fen Bilimleri, Matematik, Türkçe, Din Kültürü ve Ahlak Bilgisi) kapsaması gelmektedir. Ayrıca öne çıkan önemli bir sonuç da, evde eğitim programının sağlık sorunları nedeniyle okula devam edemeyen öğrencilerin eğitim haklarının temin edilmesinde büyük bir önem taşımasıdır.
Evde eğitim programı sayesinde, sağlık problemi yaşayan öğrenciler, eğitimlerine ara vermek zorunda kalmamaktadır.
When Science Races: the Standard of Care and Medical Negligence in the Times of Covid-19
Authors: Šolc Martin 
Published: September 2022

Abstract
When a new disease emerges, there are at first no specific medicinal products to treat it. This has also been the case in the Covid-19 pandemic. Scientists and health professionals have been trying to establish the best treatments possible using the already-existing medicines that are normally used for different indications. The off-label use of medicinal products is a standard part of medical practice. If it meets certain criteria, it is not contradictory to the standard of care. Nevertheless, the urgency of the pandemic situation brings about new issues. What amount of data on efficacy and safety should be considered sufficient to scientifically justify the off-label use of a particular medicine? How should health professionals reflect the rapid scientific developments and high levels of uncertainty in their clinical practice? How can be these factors influenced by the politicisation of medicine? The paper deals with the outlined questions in order to analyse and concretise the criteria for off-label use of medicinal product in the specific context of the Covid-19 pandemic.
Features of the Modern Protectionism of the US and the EU towards Russia
Authors: Sidorov A. A. 
Published: September 2022

The article examines the current trends and features of US and EU protectionism towards Russia, its possible consequences and ways of response. Protectionism has been increasing since 2020, which is manifested in the intensification of the use of existing instruments and the development of the new ones.The article analyzes possible consequences of the spike in countervailing investigations by the US against Russia. The author highlights possible application of similar restrictive measures by other partners as an additional risk. An unprecedented event is the US Department of Commerce review of Russia’s status as a market economy country for purposes of antidumping duty investigations. Non-market economy status expands the capabilities of the US to “overcount” dumping and impose duties, thus impeding the activity of Russian companies on foreign markets. The US acknowledged for now that there does not exist a sufficient degree of evidence to justify a change in Russia’s market economy designation, nevertheless, one cannot rule out such attempts in the future.In the EU context, the practice of energy adjustments, which results in overstated production costs, normal value and anti-dumping duties for Russian goods, is continued. A new protectionist step is the publication of the report “On significant distortions in the economy of the Russian Federation for the purposes of trade defence investigations”, which lays an additional basis for the continuation and strengthening of restrictive measures. The article analyzes a new instrument of environmental protectionism, the EU’s carbon border adjustment mechanism, a levy on imported products based on the embedded CO2 emissions. The measure will affect important positions of the Russian exports – cement, electricity, fertilizers, iron & steel and aluminum. The mechanism can be considered an attempt to make up for the EU’s lack of natural competitive advantages in mineral raw materials and to impose its vision of economic policy goals on the rest of the world.In conclusion, the author highlights features of American and European protectionism towards Russia – active employment of the role of the state in the economy factor as well as environmental factor as pretexts for introducing or tightening restrictive measures.The main ways of Russia’s response to new challenges can be the use of the WTO platform in cooperation with other countries, the search for new economic levers in relations with the partners (including application of trade defence measures), the detection of possible market distortions in the EU and the US for possible use in EAEU investigations.
Специализация и профессионализация на физико-математических факультетах российских университетов в пореформенное время
Authors: Жарова (Ekaterina Yurievna Zharova) Екатерина Юрьевна 
Published: September 2022

Абстракт
Развитие науки в XIX в. интенсифицировало появление дисциплин и углубило специализацию. Университеты формировали запросы на соответствующее разделение факультетов, однако встречали отказы со стороны Министерства народного просвещения. Последнее делало упор на подготовку в университетах учительских кадров. Указанное противоречие не было преодолено во второй половине XIX в., приведя к кризису в начале XX в.
Medical support for future large-scale combat operations
Authors: Tien Homer , Beckett Andrew 
Published: September 2022

LAY SUMMARY Assumptions for how the Canadian Armed Forces cares for injured soldiers on the battlefield may no longer hold true. Previous treatments were designed for counterinsurgency operations where Allied forces dominated the air and land during operations. However, the recent fighting in Ukraine highlights the need to develop a doctrine for pre-hospital care on the battlefield for large-scale combat operations. In these operations, modern weapons are extremely lethal, and the casualty rate is extremely high. This review examines the development of tactical combat casualty care and the assumptions behind its treatment algorithms. It suggests changes need to be made to better support Canadian soldiers if fighting in large-scale combat operations.
Evaluation of a preventive efficacy for a new anthelminthic drug Supramil® tablets regarding heartworm disease in dogs
Authors: Shinkarenko Aleksandr , Kamenov Konstantin , Mukaseev Sergey , Zeynalov Orhan 
Published: September 2022

There was studied an effectiveness of the new anthelmintic drug Supramil® tablets for prevention of dirofilariasis in dogs. With a monthly treatment of dogs free from larvae of Dirofilaria spp. with the drug Supramil® tablets, used at dose of 0.5 mg / kg on a body weight according to milbemycin oxime, in a region unfavorable for dirofilariasis, the preventive effectiveness of the drug was 100 %.
Monthly control of microfilariaemia, carried out before each drug treatment, showed an absence of larvae of Dirofilaria spp. in peripheral blood of 100% of experimental animals, which indicates not only high preventive efficacy of the drug, but also its prolonged microfilaricidal action and a possibility to use it for prevention of dirofilariasis with an interval of 28…35 days.
Thus, Supramil® tablets are highly effective to prevent dirofilariasis in disadvantaged regions.
The impact of osteopathic correction on the life quality of pregnant women
Authors: Nenashkina E. N. 
Published: September 2022

Introduction. The development of pregnancy is accompanied by a number of regular structural and functional changes in a woman′s body, which, in turn, can both reduce the level of life quality and serve as a background or a cause for the formation of somatic dysfunctions, the level of manifestation and severity of which depend on the compensatory capabilities of the female body. Therefore during this period a woman needs to ensure a high level of life quality. At the present stage the pregnancy′s support dictates the need to use an integrated approach to solving the issues of preventing the development of complications during pregnancy, as well as reducing perinatal risks for the mother and fetus. At the same time, issues of the life quality of pregnant women are often not given due attention. This dictates the need to search for methods (primarily non-drug) that contribute to improving the life quality.The aim of the study was to evaluate the impact of osteopathic correction on the life quality of pregnant women.Materials and methods. A prospective controlled randomized study conducted in the period from 03.2018 to 03.2022 on the basis of the Mokhov Institute of Osteopathy LLC Medical Clinic included 90 somatically healthy pregnant women aged 25–45 years, whose gestation period was 13–27 weeks. All pregnant women, depending on the used correction technique, were divided by a randomization envelopes method into three groups: the main (30 people), control (30 people) and comparison group (30 people). The patients of the main group received osteopathic correction (3 procedures with an interval of 10–14 days). The control group patients used physical exercises 2 times a week for 1,5 months as prescribed by a physical therapy doctor. The patients of the third group were dynamically monitored. Before and after the correction an osteopathic examination of all pregnant women was conducted with the formation of an osteopathic conclusion, and also their life quality was assessed according to the criteria of the SF-36 questionnaire.Results. For pregnant women, as the pregnancy period increases, a decrease in both the physical and psychological components of the life quality is characteristic. In the main group, compared with the control group, after osteopathic correction, there was a statistically signiﬁcant increase in the indicators of the physical and psychological components of the life quality (p=0,0024). The use of physical therapy exercises by healthy pregnant women leads to the fact that quality of life indicators tend to increase as pregnancy progresses.Conclusion. The development of pregnancy is accompanied by a number of regular structural and functional changes in a woman′s body, which in turn can reduce the quality of life. The use of osteopathic correction during pregnancy makes it possible to improve the life quality of pregnant women, and so it can be used to improve medical care for this contingent of the population.
PENGUATAN DASAR NEGARA MELALUI PENYULUHAN PANCASILA PADA MAHASISWA
Authors: Adityo Rayno Dwi 
Published: September 2022

The attempt of removes Pancasila as a basis of Indonesian still continued and almost being targeting every element of society. The target households was not the just general public like before, but those young generations such as academicians like college students. Therefore, in this community devotion programe, the hightlights is on counseling Pancasila in an effort to strengthen the state foundation for college students. A method of implementation of the devotion adopting counseling with a pattern discourse or dialogue. The results of the activity have added to the insight of student participants about the dynamics of the history of Pancasila from multiple perspectives, marked by the active response of students during the discussion process. Increasing the basics of Pancasila as a meeting point with the children of the nation's, there is concern that Pancasila as the basis of the state in its implementation has not been maximized so that it still requires the role of every citizen to socialization. Realizing the importance of understanding Pancasila returned to its citizens. In conclusion, counseling on strengthening the basis of the state is important and is carried out with various perspectives so that it can add to the public's knowledge of the importance of Pancasila and show that awareness of Pancasila cultivation has not been maximized so it requires the participation of all to continued so might Pancasila relevant all off the time.
HER2 status of CTCs by peptide-functionalized nanoparticles as the diagnostic biomarker of breast cancer and predicting the efficacy of anti-HER2 treatment
Authors: Wang Mengting , Liu Yaxin , Shao Bin , Liu Xiaoran , Hu Zhiyuan , Wang Chen , Li Huiping , Zhu Ling , Li Ping , Yang Yanlian 
Published: September 2022

Efficacy of anti-human epidermal growth factor receptor 2 (HER2) treatment is impacted by tissue-based evaluation bias due to tumor heterogeneity and dynamic changes of HER2 in breast cancer. Circulating tumor cell (CTC)-based HER2 phenotyping provides integral and real-time assessment, benefiting accurate HER2 diagnosis. This study developed a semi-quantitative fluorescent evaluation system of HER2 immunostaining on CTCs by peptide-functionalized magnetic nanoparticles (Pep@MNPs) and immunocytochemistry (ICC). 52 newly-diagnosed advanced breast cancer patients were enrolled for blood samples before and/or after first-line treatment, including 24 patients who were diagnosed with HER2+ tumors and treated with anti-HER2 drugs. We enumerated CTCs and assessed levels of HER2 expression on CTCs in 2.0 ml whole blood. Enumerating CTCs at baseline could distinguish cancer patients (sensitivity, 69.2%; specificity, 100%). 80.8% (42/52) of patients had at least one CTCs before therapy. Patients with &lt;3 CTCs at baseline had significantly longer progression-free survival (medians, 19.4 vs. 9.2 months; log-rank p = 0.046) and overall survival (medians, not yet reached; log-rank p = 0.049) than those with ≥3 CTCs. Both HER2+ and HER2-low patients could be detected with HER2 overexpression on CTCs (CTC-HER2+) (52.6%, 44.4%, respectively), whereas all the HER2-negative patients had no CTC-HER2+ phenotype. Among HER2+ patients with ≥3 CTCs at baseline, objective response only appeared in pretherapeutic CTC-HER2+ cohort (60.0%), rather than in CTC-HER2– cohort (0.0%) (p = 0.034). In conclusion, we demonstrate the significance of CTC enumeration in diagnosis and prognosis of first-line advanced breast cancer, and highlight the value of CTC-HER2 status in predicting efficacy of anti-HER2 treatment.