bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived Screen Use in Hospitalized Children: Child Life Experts’ Perspectives on More Meaningful Engagement
Authors: Arora Gitanjli , Pitt Michael B. , Vos Duncan , Carroll Kelli , Soares Neelkamal 
Published: April 2022

Objective: Children’s environments are rich with screen media, however, very little research describing screen media use for children in the hospital setting exists. Despite innovative uses of screen media by Certified Child Life Specialists to strengthen coping and provide comfort to hospitalized children, there is little guidance for how best to use screen media in addition to the gap in research. This study surveyed child life specialists in pediatric inpatient settings to describe screen media use in hospitalized children. Method & Results: Using online surveys, child life specialists reported some novel uses of screen media to aid in patient care and education and identified underutilization of media to educate patients. Conclusion: Further studies can build off of ours to assess the potential benefits and setbacks of screen use in hospitalized children. Disclosure Statement: No potential conflict of interest was reported by the author(s). Funding Statement: No funding sources were provided by the author(s).
The Influence of Early Menopause in Women with Rheumatoid Arthritis; A Systematic Review
Authors: Kazmi Zehra 
Published: April 2022

Abstract

Background: Rheumatoid arthritis is a chronic disease affecting the immune system and it particularly targets synovial joints, bringing about inflammation and causing functional limitations. Objective: To explore the evidence showing the influence of early menopause in women with rheumatoid arthritis. Methods: In this systematic review, all the literature from 2010 to 2019 was searched with specific keywords “menopause, premature menopause, early menopause, rheumatoid arthritis, rheumatic diseases” with the use of Boolean operators. Databases that were thoroughly searched included Google Scholar, PubMed and HEC digital library. After careful screening, 10 studies that met the inclusion criteria were included in the review. The quality of these articles was assessed using the AXIS tool for that cross-sectional studies. Results: These studies indicated that post-menopausal women are at higher risk of developing rheumatoid arthritis and they are more likely to have early or premature menopause (in ≤45 years). At baseline, the post-menopausal women had high health assessment questionnaire scores than pre-menopausal women. Conclusion: This review states that menopausal women are highly at risk of developing rheumatoid arthritis, especially those experiencing this at an early age and this condition can also worsen arthritic symptoms. Hormonal changes may influence pathways that are distinct from those leading to severe and progressive rheumatoid arthritis.
*Corresponding author: Zehra Kazmi, University Institute of Physical Therapy, University of Lahore, Lahore, Pakistan; Email: zaza.kazmi110@gmail.com
Citation: Kazmi Z. 2021. The influence of early menopause in women with rheumatoid arthritis; a systematic review. The Healer Journal of Physiotherapy and Rehabilitation Sciences, 1(1):27-37.
Latest Trends in Physical Therapy: Extracorporeal Shockwave Therapy
Authors: Fatima Dr. Arooj 
Published: April 2022

Extracorporeal Shockwave therapy is a scientifically-based therapeutic modality used for treating variety of musculoskeletal disorders. This medical tool is gradually paving its way among the armamentarium of interventions for musculoskeletal conditions, along with its pros and cons. As mirrored by the valuable evidence from the contemporary studies, pending queries await to be resolved related to the mechanism of action of this treatment, the optimal therapy protocol, frequency of sessions, amount of energy applied. For satisfactory and effective alleviation of symptoms, there is need for such type of differential treatment which may contribute to make patient’s condition better.
Shockwave therapy is found to be effective for the treatment of tendinopathies, as it may elicit an anti-inflammatory and analgesic response, thus helps in regenerating tissue. Shockwaves are high-pressure acoustic waves that can minimize the enthesopathic pain and increase functionality of patients. This intervention is used as alternative therapy for calcified and non-calcified rotator cuff tendinopathy, Achilles or patellar tendinopathy thus it reduces the need for surgery. These are considered as common medical conditions and the physical therapy rehabilitation plays a significantly important role to recover these patients. The rehabilitation program of patients having tendinopathy creates an immense challenge for rehabilitation specialists and therapists.
La Estrategia Competitiva en la Cadena de Comercialización de Productos Agroexportables
Authors: Alponte Montoya Alberto Miguel 
Published: April 2022

El sector de agricultura del país carece de herramientas de gestión para lograr sostenibilidad de abastecer mercados internacionales ante este panorama se ve conveniente que los agricultores o productores, deben aplicar estrategias para mejorar la producción con la visión de exportación. En la actualidad el sector de agricultura, presentan carencias	de	estrategias competitivas orientadas para afrontar a las actividades que se presenta en la cadena de comercialización para exportación. Por los siguientes motivos: i) el agricultor no recibe información confiable para desarrollar el cultivo, solo se guía por el precio que tiene en el mercado, teniendo el pensamiento “si tiene buen precio, siembro el producto”; ii) el agricultor no tiene herramientas ni conocimientos para negociar con el mercado nacional e internacional; iii) el agricultor no prioriza la calidad de la producción; iv) el agricultor recién muestra interés de vender la producción, justo antes de la cosecha. El mercado internacional solicita producto en donde enfatizan elementos como son la calidad y volumen, ante ello solo las grandes empresas agroexportadoras pueden cumplir con la exigencia, pero el resto de la agricultura que desea exportar se les dificulta poder llegar a ese requerimiento. Al aplicar una estrategia como es el caso específico de homogenizar los cultivos en una determinada época del año, con el objetivo de incrementar el volumen de producción y de esta manera ofertar en el mercado internacional, por consecuencia abarcando más mercados potenciales se podría cumplir con un elemento que es el volumen de exportación que el mercado demanda. Por lo tanto, es importante que las empresas o el sector agrícola busquen aplicar mecanismos para concretar la calidad de la producción, respaldado por un adecuado asesoramiento permanente de profesional especialista en gestionar y controlar un adecuado manejo del cultivo, el elemento de la calidad es una cualidad que tiene injerencia en el precio, en consecuencia, también en la oportunidad de mercado que puede tener el agricultor.
El cohousing senior en España. Cambios desde la economía social en los alojamientos y en la economía de los cuidados para personas mayores
Authors: Tortosa Chuliá Mª Ángeles , Sundström Gerdt 
Published: April 2022

sociales en la actualidad presentan muchas deficiencias, que se han evidenciado especialmente con el COVID-19. Estos hechos han convertido al cohousing senior en una atractiva alternativa de alojamiento para ellos. El avance del cohousing senior supone un empuje hacia la modernización de los alojamientos y servicios sociales para las personas mayores, en particular de las residencias. El cohousing senior lleva varios años de experiencia en otros países europeos, y representa una forma de convivir deseable entre los mayores y/o las familias que desean compañía y compartir tareas. Para conocer mejor la posible evolución futura del cohousing senior se introducen algunos apuntes del desarrollo de estos alojamientos en Suecia, un país modelo y guía en materia de políticas de viviendas y cuidados para personas mayores. El objetivo de este artículo es analizar el crecimiento de los alojamientos colaborativos para personas mayores en España desde la economía social, y conocer los problemas encontrados en su implementación, y las soluciones e impulsos políticos a su desarrollo. Hemos revisado la literatura española e internacional sobre cohousing senior durante la última década, y buscado datos en España sobre estos alojamientos en la prensa local y nacional y en la base de datos del proyecto MOVICOMA para determinar su grado de implantación y características. También se consultaron los barómetros de UDP sobre cohousing. Y hemos encontrado que su funcionamiento en Españaes incipiente, y que existen pocas iniciativas consolidadas, aunque bastantes en marcha, y se comprueba que la economía social juega un papel primordial. El Covid-19 ha elevado la demanda de estos alojamientos y alternativas de cuidado porque promueven y facilitan contactos sociales, evitan riesgos de las residencias, y mantienen a los participantes activos. Pero su implementación es lenta porque cuentan con importantes limitaciones a nivel de diseño, localización, financiación, burocracia excesiva y escaso apoyo público. Últimamente, a nivel político hay un mayor interés por estos alojamientos. Los planes de recuperación del Gobierno de España y algunas regulaciones de las CCAA y Ayuntamientos incorporan estrategias específicas sobre viviendas, otras para la Economía Social y cooperativas, y para el cuidado de los mayores (SAAD) que afectan directa o indirectamente al cohousing senior.
La creatividad en entidades de la Economía Social: una visión desde casos múltiples y una metodología mixta
Authors: Ureña Espaillat Hayrold José , Briones Peñalver Antonio Juan , Bernal Conesa Juan Andrés 
Published: April 2022

Los nuevos modelos de creatividad, de conocimiento y sostenibilidad merecen conocerlos, aún más en las Entidades de Economía Social (en adelante EES) con una lógica de gestión unitaria. Este artículo, en base a un estudio de casos múltiples y usando cuestionarios focalizados en expertos, tiene a priori el propósito de conocer su visión de los diversos ecosistemas institucionales que orbitan alrededor de los ejes temáticos de la economía social, especialmente los centros de formación y cooperativas educativas. En el proceso se utilizaron las etapas de la metodología Delphi para la comprobación teórica de las relaciones y una depuración de los indicadores. A continuación, se ha realizado un análisis de regresión de mínimos cuadrados parciales PLS SEM con el propósito de que el estudio estadístico sea comprobable. La aportación del artículo nos lleva a establecer estrategias en el ámbito de la sostenibilidad de las EES, a través de un estudio empírico, y que se fueron identificadas a través de la gestión de la creatividad en cooperativas de la educación, ONGs y fundaciones relacionadas con la formación técnica especializada.
Historical accidental font in the works of artists of the "Culture League"
Authors: Kotliar Elena Romanovna , Shirina Nadezhda Sergeevna 
Published: April 2022

The subject of the study is the historical accidental font used in the works of members of the Jewish art organization. "Culture League".The object of the study is the accidental font as an instrument of semantic and stylistic definition of these works within the framework of Jewish culture. The research uses methods of analysis of visual symbols in the works of members of the art section of the "Culture League" and their semantics, methods of synthesis and historicism in the formulation of the definition of historical accidental font. On the basis of the studied works of A. G. Shitsgal, T. O. Ivanenko, V. I. Lesnyak, the definition of historical accidental font is formulated; on the basis of the works of A. Amishai-Maisels, G. Kazovsky, B. Khaimovich, the prerequisites for the emergence of the Jewish artistic avant-garde and the foundation of the association "Culture League" are determined; works on avant-garde stylistics and semiotics of Jewish art by I. A. Sergeeva, O. A. Lagutenko, E. Frenkel made it possible to carry out a semantic and stylistic analysis of the accidental font in the works of artists of the "Culture League". The main conclusions of the study are: 1.	The historical accidental font is a marker of a certain epoch and ethno-national culture. Its application allows artists to convey at the semiotic level not only the verbal meaning of the text, but also to expand its meaning to a global, socio-cultural level. 2.	The Jewish association "Kulturliga" was part of the global artistic avant-garde of the first third of the twentieth century. The main goal and program of the association was the development of Jewish culture using new stylistic methods in the spirit of the times, with the use of avant-garde styles. The accidental Jewish traditional font was a clear indication that the work belonged to the Jewish branch of the artistic avant-garde. A special contribution of the authors is the formulation of the definition of "historical accidental font". For the first time, the authors analyzed the use of accidental font in the works of artists of the "Culture League". Keywords: historical accidental font, "Culture League", avant-garde, cubo-futurism, expressionism, Jewish shtetl.
A Study on Working Pattern and Performance of Farmer Producer Organisations in Andhra Pradesh
Authors: Vedasri R. , Mishra R. K. , Mishra S. N. 
Published: April 2022

Background: The study aimed at determining the impact of socio economic characteristics of member farmers on the performance of Farmer Producer Organisations in Andhra Pradesh and to know the extent of services provided by the FPOs to the members. It is typically a society or company consisting of practicing farmers who are also actual producers of a specified commodity or commodities, and is formed under mutually aided co-operative societies (MACS) Act 1995 or as farmer producer companies act (FPC) 2013. Small Farmers’ Agribusiness Consortium (SFAC) is providing support for promotion of FPOs.
Methods: A total of 120 farmers selected from six FPOs spread across three regions of Andhra Pradesh constituted the sample size. Multiple regression analysis was employed to study the impact of socio economic traits for the progressive development and expansion of FPOs.
Results: The working pattern of FPOs showed that the group membership was increasing year by year and the procurement of produce was also increasing year by year their by increasing in the turnover of the FPOs. The results showed that education, experience and annual income were determinant factors that influenced the performance of FPOs.
A Review on Kawasaki Disease
Authors: Jing Yao , Weiyv . , Yong Jiao Fu 
Published: April 2022

Kawasaki disease is an acute, self-limited vasculitis of unknown etiology, which mainly occurs in infants and children. The target organs of Kawasaki disease are coronary arteries and other cardiovascular structures. The initial manifestations of Kawasaki disease are high fever, inflammation of skin and mucosa, and enlargement of cervical lymph nodes. About 25% of children who are not treated with intravenous immunoglobulin during the acute phase of the disease will develop coronary artery aneurysms. Nowadays, Kawasaki disease has replaced rheumatic fever as the main cause of acquired heart disease in children in developed countries. However, there is still no specific diagnostic test, echocardiography is still the main diagnostic method of coronary artery involvement in children with Kawasaki disease, and risk stratification assessment is carried out according to Z value to assist in the short-term and long-term diagnosis and treatment of Kawasaki disease. In the aspect of treatment, there are reports on the application of corticosteroids, infliximab, cyclosporine, methotrexate, interleukin receptor blockers and so on.
This article makes a detailed elaboration on the epidemiology, pathology, diagnostic criteria, differential diagnosis, treatment and prognosis of Kawasaki disease, so as to improve clinicians' understanding of Kawasaki disease and reduce misdiagnosis possible.
EFL Instructors’ and Students’ Perception and Practice towards Action Research
Authors: Shiferaw Adula Habtamu 
Published: April 2022

Aims: To explore EFL instructors’ and students’ perception and practice towards action research in College of Teachers Education.
Study Design: Qualitative data gathered through the general open-ended questionnaire used thematically organized, transcribed and analyzed in this study.
Place and Duration of Study: Perception and practice towards action research were obtained from College of Teachers Education, Ethiopia, at Oromia region.
Methodology: To achieve this objective, semi-structured interview (filled out by five EFL instructors, 10 third year English Language students, research and publication committee members, Dean Interview and Focus Group Discussion) was used in this study.
Results: The results indicate that most of the respondents show good perception concerning the significance of action research in improving their teaching practice, solving students’ academic and non-academic problems, developing team spirit and mutual support among teacher educators, creating opportunities to increase their academic writing skills, and developing personal professional perception respectively. The practices of action research in the college were ineffective. There were perceived challenges like shortage of resources for support, budget and material, low top management attention, instructors’ dual role as teachers and researchers, initiation and recognition by trainers themselves.
Conclusion: Students were not satisfied by research advisors’ provision of professional assistance in action research on practicum courses and carried out action research in a similar fashion (i.e., plagiarism), English Language instructors’ provisions of advice to students in action research on practicum course were found to be low. Instructors were found have not conceptual problem about action research both the theoretical and practical aspects, other than they lacked commitment, encouragement and diligence were attributed to lack of proper incentives and other essential facilities.
Development and Validation of an HPLC-MS/MS Method for the Determination of Remdesivir in Rat Plasma
Authors: Rao Naidu Srinivasa , Adimulapu Anilkumar , Babu B. Nagendra , Rambabu G. 
Published: April 2022

Background: Remdesivir is an excellent drug for the medication of covid-19.So; it is an interesting method to develop a novel and reliable HPLC-MS strategy for establishment of Remdesivir.
Objective: To develop a new rapid and sensitive HPLC-MS/MS method for the estimation of Remdesivirin rat plasma using D4- Remdesivir.
Methods: Separation was carried on Inertsil ODS column (150x4.6mm, 3.5µm) using a isocratic elution with a buffer containing 1ml of tri ethyl amine in 1Litre of water and the mixture of two components like Buffer and Acetonitrile in the ratio of 50:50 as mobile phase with 1ml/min flow rate at ambient temperature.
Results: Analysis was performed within 10 minutes over a good linear concentration range from 1ng/ml to 20ng/ml(r2 = 0.999) for Remdesivir .Precision and recovery study results were within the acceptable limit. Anelectro spray ionization source was used to study Remdesivir. This method has been successfully applied; exploring Remdesivir with its internal standard (D4- Remdesivir) was extracted from rat plasma using liquid-liquid extraction.
Conclusion: This paper focuses on the consistent evaluation of key bio-analytical validation parameters, including accuracy, precision, sensitivity, selectivity, and standard curve, quantification limits, range, recovery, and stability. In the case of chromatographic methods used in bio analysis, these validation parameters are defined, along with examples of validation methodology.
MED12‐related Hardikar syndrome: Two additional cases and novel phenotypic features
Authors: Pillai Nishitha R. , Miller Dana , Bronken Grace , Salunke Amrita Kahlon , Aggarwal Anjali 
Published: April 2022

AbstractHardikar syndrome (HS) is a MED12‐related ultra‐rare multiple congenital malformation syndrome known to affect the gastrointestinal, cardiac, and genitourinary systems among other features including cleft lip/palate and pigmentary retinopathy. Only 10 patients affected with HS have been previously described in literature, of which seven were molecularly confirmed. We report a 20‐year‐old and a 13‐month‐old patient with HS diagnosed by exome sequencing bringing the total number of clinically diagnosed cases to 12 and MED12 associated to 9. We describe previously unreported molecular and clinical findings associated with HS and review all reported cases to permit prompt diagnosis, appropriate management, and genetic counseling of HS patients.
Investigation of the Molecular Landscape of Bacterial Aromatic Polyketides by Global Analysis of Type II Polyketide Synthases
Authors: Chen Shanchong , Zhang Chi , Zhang Lihan 
Published: April 2022

AbstractAromatic polyketides biosynthesized by microorganisms are a prominent class of natural products widely used in clinical treatments. Although genome mining approaches have accelerated the discovery of these molecules, the molecular diversity, abundance, and distribution of bacterial aromatic polyketides at a global scale remain elusive. Here, we provide a global atlas of bacterial aromatic polyketides based on large‐scale analysis of type II polyketide synthases. We first established the chain length factor protein as a marker that can predict both chemical class and molecular uniqueness of the biosynthetic product, and analyzed the abundance, taxonomic distribution, estimated structural diversity, and the total number of aromatic polyketides in bacteria. We further show the identification of oryzanaphthopyrans with an unprecedented angular naphthopyran scaffold from a rare actinobacterium by genome mining guided by the global atlas. These results serve as a compass for exploiting the entire type II polyketide synthase‐derived aromatic polyketides in bacteria.
Optimizing nanoencapsulation of Heracleum lasiopetalum by response surface methodology
Authors: Yazdan‐Bakhsh Mahsa , Nasr‐Esfahani Mojtaba , Esmaeilzadeh Kenari Reza , Fazel‐Najafabadi Mohammad 
Published: April 2022

AbstractThis study was carried out to optimize formulation for Heracleum lasiopetalum (golpar) extract nanoencapsulation by response surface methodology (RSM). The primary water‐in‐oil emulsion was fabricated by (5%–10%) golpar extract (GE), (40%–35%) emulsifier span 80 (EM), and (50%–60%) sunflower oil (SO). The coating materials were the mixture of Lepidium sativum seed gum (LSG) and whey protein concentrate (WPC) at different ratios (1:0, 1:1, and 0:1). The yield of nanoencapsulation of GE, particle size, and zeta potential was investigated as responses of RSM. The optimal formulation for water‐in‐oil‐in‐water emulsion of GE were SO: 50.46%, GE 9.52%, and EM: 36.30% in LSG, SO: 57.07%, GE: 7.12%, and EM: 30.85% in LSG:WPC, and SO: 54.98%, GE: 9.05%, and EM: 39.87% in WPC coating. In conclusion, the nanoencapsulation of GE prepared with the optimized formulation by RSM ensures the gradual release and higher stability to sedimentation during storage with nanometric size and high yield of encapsulation. The nanocapsules of GE can be used as a natural antioxidant in food systems.