bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prevalence and prognosis of next‐generation therapeutic targets in metastatic castration‐resistant prostate cancer
Authors: Pan Jian , Zhao Jinou , Ni Xudong , Gan Hualei , Wei Yu , Wu Junlong , Zhang Tingwei , Wang Qifeng , Freedland Stephen J. , Wang Beihe , Song Shaoli , Ye Dingwei , Liu Chang , Zhu Yao 
Published: October 2022

The success of the PROfound, IPATential150, and TheraP trials promoted the transition from sequential treatment to therapeutic targets (TTs)‐guided precision treatment in metastatic castration‐resistant prostate cancer (mCRPC). The objective of this study was to evaluate the prevalence and prognostic value of TTs from these three trials. All included Chinese mCRPC patients underwent circulating tumor DNA (ctDNA) sequencing, PTEN status assessment, and dual‐tracer [68Ga‐prostate‐specific membrane antigen (PSMA) and 18F‐fluorodexyglucose (FDG)] positron emission tomography/computed tomography (PET/CT). Previous treatment with cabazitaxel, Lu‐PSMA or olaparib was unallowed. Patients with known significant sarcomatoid or spindle cell or neuroendocrine small cell components were also excluded. TTs were defined as positive as follows: (a) high PSMA and no PSMA−/FDG+ disease on dual‐tracer PET/CT scans; (b) defects in homologous recombination repair (HRR) genes in ctDNA; and (c) loss of PTEN immunohistochemistry staining in tumor tissue. The prevalence and prognostic value on progression‐free survival (PFS) of TTs were evaluated. A total of 106 consecutive mCRPC patients were included. The prevalence of positive PET/CT, HRR defect, and PTEN loss was 30%, 29% and 16%, respectively. Sixty‐three patients had at least one TT. Metastatic volume (odds ratio = 5.0; P = 0.017) was the only independent factor of positive TT in multivariate analysis. Seventy‐four patients received abiraterone after TT screening. Patients with positive PET/CT (P = 0.011) and HRR defect (P = 0.002) had a significantly shorter PFS after receiving abiraterone than patients with negative TTs. However, PTEN status was unrelated to PFS, which may be due to a less number of patients with PTEN loss (P = 0.952). Overall, patients with any positive TTs had a significantly shorter PFS after abiraterone than patients with negative TTs (P = 0.009). Nearly 60% of Chinese patients with mCRPC who had a poor prognosis on abiraterone were candidates for precision treatments based on the specific criteria of TTs.
Flexible CO2 Sensor Architecture with Selective Nitrogen Functionalities by One‐Step Laser‐Induced Conversion of Versatile Organic Ink
Authors: Wang Huize , Ogolla Charles Otieno , Panchal Gyanendra , Hepp Marco , Delacroix Simon , Cruz Daniel , Kojda Danny , Ciston Jim , Ophus Colin , Knop‐Gericke Axel , Habicht Klaus , Butz Benjamin , Strauss Volker 
Published: October 2022

AbstractNitrogen‐containing carbons (NC) are a class of sustainable materials for selective CO2 adsorption. A versatile concept is introduced to fabricate flexible NC‐based sensor architectures for room‐temperature sensing of CO2 in a one‐step laser conversion of primary films cast from abundant precursors. By the unidirectional energy impact in conjunction with depth‐dependent attenuation of the laser beam, a layered sensor heterostructure with a porous transducer and active sensor layer is formed. Comprehensive microscopic and spectroscopic cross‐sectional analyses confirm the preservation of the high content of imidazolic nitrogen in the sensor. The performance is optimized in terms of material morphology, chemical composition, and surface chemistry to achieve a linear relative resistive response of up to ΔR/R0 = −14.3% (10% of CO2). Thermodynamic analysis yields ΔadsH values of −35.6 and 34.1 kJ·mol−1 for H2O and CO2, respectively. The sensor is operable even in humid environments (e.g., ∆R/R0,RH = 80% = 0.53%) and shows good performance upon strong mechanical deformation.
Genetically Engineered Protein Corona‐based Cascade Nanozymes for Enhanced Tumor Therapy
Authors: Liu Zhijun , Liu Qiqi , Zhang Haoqi , Zhang Xiangyun , Wu Jin , Sun Zhiyuan , Zhu Mingsheng , Hu Xueyan , Qi Tianyi , Kang Helong , Chen Rui , Huang Xinglu , Zhuang Jie 
Published: October 2022

AbstractThe emergence of nanomedicine has provided a promising strategy to greatly enhance the therapeutic efficacy of O2‐dependent photodynamic therapy (PDT). However, plasma‐derived protein corona and/or discontinuous O2 supply substantially limit their tumor delivery efficiency and therapeutic outcomes. Herein, protein corona cloaking‐based cascade nanozymes are developed using genetically engineered human ferritin heavy chain nanocages (FTn) as unique pre‐coated protein corona and cascade nanozymes as steady O2 suppliers. Specifically, FTn is coated onto mesoporous silica nanoparticles (MSNs) to form FTn‐based protein corona, providing active targeting of tumor cells by binding with its receptor. In situ synthesis of ultra‐small Au nanoparticles in MSNs, and biomimetic incorporation of Ru nanoclusters into FTn inner cavity showed glucose oxidase‐like activity and catalase‐like activity, respectively. The two nanozymes are incorporated into MSNs nanoplatform to induce cascade and circular catalytic reactions by consuming glucose and H2O2 within the tumor microenvironment. Compared to MSNs alone, the FTn‐based protein corona is capable of efficiently diminishing plasma‐derived protein corona formation to prolong blood circulation time and improving in vitro tumor cell uptake and in vivo tumor accumulation, thereby providing significantly enhanced therapeutic benefits of PDT by combining with the continuously produced O2 of cascade nanozymes.
Extended Near‐Infrared Photovoltaic Responses of Perovskite Solar Cells by p‐Type Phthalocyanine Derivative
Authors: Zhang Zhenhu , Liu Hongli , Wang Shirong , Bao Huayu , Zhang Fei , Li Xianggao 
Published: October 2022

AbstractThe absent photo‐response in near‐infrared (NIR) light (>800 nm) of lead‐based perovskite solar cells (PSCs) limits the further improvement of their power conversion efficiency (PCE). Here, a narrow bandgap p‐type phthalocyanine derivative (Copper(II) 2,3,9,10,16,17,23,24‐octakis((4‐(bis(4‐methoxyphenyl)amino)phenyl)ethynyl)phthalocyanine –8TPAEPC) with NIR absorption is synthesized to extend the photovoltaic response of perovskite to 850 nm. After doping the 8TPAEPC into the perovskite photoactive layer, the perovskite crystal quality is improved, resulting in its good electrical conductivity and less surface defects. Furthermore, the molecules stacking on the grain boundaries construct the charge transportation paths, as well as the p–n bulk heterojunction with enhanced built‐in potential. The target PSCs are optimized with notably enhanced PCE from 20% up to 22.10%, and excellent stability that is over 80% of the initial level at 70–80% relative humidity can be maintained for more than 500 h, benefiting from the improved hydrophobicity of 8TPAEPC. In addition, 8TPAEPC also serves as a dopant‐free, highly carrier‐mobile, and moreover, NIR‐responsive hole transport layer (HTL) with boosted PCE of 20.42% that reaches state of the art level among the dopant‐free metal phthalocyanines HTL‐based PSCs.
Observation of Surface Superconductivity in a 3D Dirac Material
Authors: Liu Qi , Guo Peng‐Jie , Yue Xiao‐Yu , Yi Zhe‐Kai , Dong Qing‐Xin , Liang Hui , Wu Dan‐Dan , Sun Yan , Li Qiu‐Ju , Zhu Wen‐Liang , Xia Tian‐Long , Sun Xue‐Feng , Wang Yi‐Yan 
Published: October 2022

AbstractSuperconductivity becomes more interesting when it encounters dimensional constraint or topology because it is of importance for exploring exotic quantum phenomena or developing superconducting electronics. Here, the coexistence of naturally formed surface superconducting state and 3D topological Dirac state in single crystals of BaMg2Bi2 is reported. The electronic structure obtained from the first‐principles calculations demonstrates that BaMg2Bi2 is an ideal Dirac material, in which the Dirac point is very close to the Fermi level and no other energy band crosses the Fermi level. Superconductivity up to 4.77−−5.17 K can be observed under ambient pressure in the measurements of resistivity. The anisotropic upper critical field and angle dependent magnetoresistance reveals the 2D characteristic of superconductivity, indicating that superconductivity occurs on the surface of the sample and is absent in the bulk state. The study not only provides BaMg2Bi2 as a suitable platform to study the interplay between superconductivity and topological Dirac state but also indicates that MgBi‐based materials may be a promising system for exploring new superconductors.
Bone Repair Biomaterials: A Perspective from Immunomodulation
Authors: Wang Yili , Zhang Hao , Hu Yan , Jing Yingying , Geng Zhen , Su Jiacan 
Published: October 2022

AbstractWith an increasingly aging society, bone defects and fractures have become significant threats to human health and quality of life. Currently, autologous and allogeneic bone grafts remain the “gold standard” for the clinical treatment of bone repair. However, bone transplantation is still clinically insufficient, owing to its substantial limitations, such as graft rejection, donor functional defects, and risk of infection. Therefore, a variety of biomaterials have been developed to facilitate bone repair. With the advancement of bone tissue engineering, the focus of research has transitioned from bioinert to bioactive biomaterials. However, many biomaterials have not achieved satisfactory therapeutic effects. In recent years, advancements in osteoimmunology have revealed that the immune system, of which macrophages are critical components, plays an essential regulatory role in bone regeneration. In this review, the role of macrophages in bone healing is explored and recent developments in biomaterials that promote bone regeneration by modulating macrophage polarization and improving the osteoimmune microenvironment are reviewed. This review provides a reference for the development and clinical application of bone repair biomaterials from the immunomodulation perspective.
Co‐Delivery of an Amyloid‐Disassembling Polyphenol Cross‐Linked in a Micellar Shell with Core‐Loaded Antibiotics for Balanced Biofilm Dispersal and Killing
Authors: Tian Shuang , van der Mei Henny C. , Ren Yijin , Busscher Henk J. , Shi Linqi 
Published: October 2022

AbstractAmyloid‐fibers help to maintain the structure of infectious biofilms. Disassembly of amyloid‐fibers contributes to biofilm‐dispersal in the blood‐circulation, from which bacteria should be cleared by the host immune system. However, often the immune system is insufficiently prepared for increasing bacterial concentrations in blood, causing septic symptoms. Here, poly(ethylene glycol)/poly(β‐amino ester), pH‐responsive micelles are prepared for co‐delivery of (‐)‐epigallocatechin‐3‐O‐gallate (EGCG) as a dispersant. Hydrophilic EGCG can not be loaded in the micellar core, but is cross‐linked in the micellar shell through pH‐reversible, boronic‐ester binding. Disassembly of micelles under acidic biofilm conditions facilitates release of EGCG and dispersal of biofilm‐bacteria. When core‐loaded with ciprofloxacin, in‐shell EGCG prevents ciprofloxacin‐leakage at physiological pH. Bacterial killing by core‐loaded ciprofloxacin in Staphylococcus aureus biofilms is enhanced when released in combination with EGCG in vitro and in vivo. In mice, micelles with in‐shell EGCG self‐target after tail‐vein injection to an infection site, yielding dispersal of pathogens with mild septic symptoms and bacterial killing by the immune system. Septic symptoms disappear slightly faster when micelles are additionally core‐loaded with ciprofloxacin. Thus, micelles with in‐shell EGCG yield balanced biofilm dispersal inducing only mild septic symptoms, which is good news in an era of increasing antibiotic‐resistance.
Interlock Protective System from Hyperbranched Polyethyleneimine and Choline Phosphate Liposome for Targeted In Vivo Gene Delivery
Authors: Jiang Sangni , Li Shengran , Mei Weikang , Zhang Jinyuan , Wu Yijun , Liu Sanrong , Yu Xifei 
Published: October 2022

AbstractBoth hyperbranched polyethyleneimine (hPEI) and cationic lipids exhibit excellent gene transfection efficiency, while their high toxicity, easily to be cleared in the blood, and have no targeting effect, which severely limits their application in in vivo gene delivery. In view of the above problems, the synergistic effects between hPEI and choline phosphate lipid (CP‐lip) are used to develop an interlock protective system to deliver genes in vivo which combines stability, transfection efficiency, and biosafety. In this work, DNA, hPEI, and CP‐lips are combined and interacted strongly to form a targeted liposome (tCP‐lipo/(PEI/DNA)). This interlock protective system could deliver genes to tumor sites after circulate in the blood with safety, then the loaded genes are transfected to kill cancer cells. The interlock protection system constructed by CP‐lips and hPEI provides an efficient and safe platform for targeted gene delivery in vivo.
Highly Efficient Double‐Side‐Emitting Electroluminescent Quantum Dot Thin Film with Transparent MoO3/Ag:Cu/MoO3 Electrode Prepared by Thermal Co‐Evaporation
Authors: Yang Shuan , Chen Hsueh‐Shih 
Published: October 2022

AbstractSee‐through double‐side‐emitting electroluminescent quantum‐dot light‐emitting‐diodes (QLEDs) with highly transparent tri‐layer MoO3/Ag:Cu/MoO3 electrode is demonstrated in this study. The tri‐layer MoO3/Ag: Cu/MoO3 electrode is prepared by a thermal co‐evaporation process, in which MoO3 is utilized as both a seed layer and a capping layer. This tri‐layer structure improves the transmittance as high as ≈88% and ≈86% for pure Ag and Ag:Cu at 550 nm, respectively. It is also found that minor Cu doping significantly improves the thermal stability and sheet resistance of Ag film. With the see‐through tri‐layer film as a device cathode, transparent double‐side‐emitting green QLED exhibits remarkable high brightness of 225, 500 cd m−2, the current efficiency of 58.68 cd A−1, the external quantum yield of 16.70%, and transmittance of 77% at 550 nm without any additional anti‐reflection coating.
Microfluidic Pumps with Laser Streaming from Tips of Optical Fibers and Sewing Needles
Authors: Tong Tian , Yue Shuai , Li Runjia , Lin Feng , Chen Di , Xing Xinxin , Chu Wei‐Kan , Song Gangbing , Liu Dong , Wang Zhiming , Bao Jiming 
Published: October 2022

AbstractThe discovery of photoacoustic laser streaming has opened up a new avenue to manipulate and drive fluids with light, but the necessity of an in situ “launch pad” has limited its utility in real‐world microfluidic applications due to both the size constraint and the complexity of fabrication. Here, it is demonstrated that 1) a versatile microfluidic pump can be materialized by using laser streaming from an optical fiber, and 2) laser streaming can be generated from a flat metal surface without any fabrication process. In the latter case, by focusing laser on the tip of a sewing needle tip, the needle can be turned into a micropump with controllable flow direction. Additionally, high‐speed imaging of the fluid motion and computational fluid dynamics simulations to confirm the photoacoustic principle of laser streaming are employed, and it is revealed that the streaming direction is determined by the direction of strongest intensity in the divergent ultrasound wavefront. Finally, the potential of laser streaming for microfluidic and optofluidic applications is demonstrated by successfully driving fluid inside a capillary tube.
Fatty Liver/Adipose Tissue Dual‐Targeting Nanoparticles with Heme Oxygenase‐1 Inducer for Amelioration of Obesity, Obesity‐Induced Type 2 Diabetes, and Steatohepatitis
Authors: Hong Juhyeong , Kim Yong‐Hee 
Published: October 2022

AbstractPersistent uptake of high‐calorie diets induces the storage of excessive lipid in visceral adipose tissue. Lipids secreted from obese adipose tissue are accumulated in peripheral tissues such as the liver, pancreas, and muscle, and impair insulin sensitivity causing type 2 diabetes mellitus (T2DM). Furthermore, the accumulation of inflammatory cytokines and lipids in the liver induces apoptosis and fibrogenesis, and ultimately causes nonalcoholic steatohepatitis (NASH). To modulate obese tissue environments, it is challenged to selectively deliver inducers of heme oxygenase‐1 (HO‐1) to adipose tissue with the aid of a prohibitin targeting drug delivery system. Prohibitin binding peptide (PBP), an oligopeptide targeting prohibitin rich in adipose tissue, is conjugated on the surface of Hemin‐ or CoPP‐loaded poly(lactide‐co‐glycolide) nanoparticles (PBP‐NPs). PBP‐NPs efficiently differentiate lipid storing white adipocytes into energy‐generating brown adipocytes in T2DM and NASH models. In addition, PBP‐NPs are found to target prohibitin overexpressed fatty liver in the NASH model and inhibit hepatic uptake of circulating lipids. Furthermore, PBP‐NPs switch phenotypes of inflammatory macrophages in damaged organs and lower inflammation. Taken together, dual‐targeted induction of HO‐1 in fatty adipose and liver tissues is proven to be a promising therapeutic strategy to ameliorate obesity, insulin resistance, and steatohepatitis by lowering lipids and cytokines.
Induced Ferromagnetism in Epitaxial Uranium Dioxide Thin Films
Authors: Sharma Yogesh , Paudel Binod , Huon Amanda , Schneider Matthew M. , Roy Pinku , Corey Zachary , Schönemann Rico , Jones Andrew C. , Jaime Marcelo , Yarotski Dmitry A. , Charlton Timothy , Fitzsimmons Michael R. , Jia Quanxi , Pettes Michael T. , Yang Ping , Chen Aiping 
Published: October 2022

AbstractActinide materials have various applications that range from nuclear energy to quantum computing. Most current efforts have focused on bulk actinide materials. Tuning functional properties by using strain engineering in epitaxial thin films is largely lacking. Using uranium dioxide (UO2) as a model system, in this work, the authors explore strain engineering in actinide epitaxial thin films and investigate the origin of induced ferromagnetism in an antiferromagnet UO2. It is found that UO2+x thin films are hypostoichiometric (x<0) with in‐plane tensile strain, while they are hyperstoichiometric (x>0) with in‐plane compressive strain. Different from strain engineering in non‐actinide oxide thin films, the epitaxial strain in UO2 is accommodated by point defects such as vacancies and interstitials due to the low formation energy. Both epitaxial strain and strain relaxation induced point defects such as oxygen/uranium vacancies and oxygen/uranium interstitials can distort magnetic structure and result in magnetic moments. This work reveals the correlation among strain, point defects and ferromagnetism in strain engineered UO2+x thin films and the results offer new opportunities to understand the influence of coupled order parameters on the emergent properties of many other actinide thin films.
Quantum Fisher Information and Lee‐Yang Zeros with Quantum Coherence of the Isotropic XY$XY$ Model and the Energy Scale
Authors: Tao Hong , Shao Lei , Zhang Zhucheng , Zhang Xingyu , Zhang Rui , Chen Jie , Lu Wangjun 
Published: October 2022

AbstractLee‐Yang zeros lie on the complex plane of the control parameters for many‐body systems with finite size, such as the transverse magnetic field and the inverse temperature. Here, an anisotropic spin system with nearest‐neighbor interactions for finite‐size parity space is considered. The Lee‐Yang zeros are obtained in anisotropic model for the complex plane of the transverse magnetic field and in the isotropic model for the complex fugacity plane of the quantum coherence. A characteristic function to represent the probe spin coherence for the isotropic model, and study on Lee‐Yang zeros, quantum coherence, and quantum Fisher information at the complex fugacity plane is presented. The relationship between quantum Fisher information and quantum coherence in decoherence channels is demonstrated and it is illustrated that information cannot be acquired at high temperatures. Meanwhile, the ground‐state energy on the complex plane for the anisotropic model is studied and the free energy cumulants with the partition function of the anisotropic model for parity space is calculated.
Sequential and Reversible Phase Transformations in Zero‐Dimensional Organic‐Inorganic Hybrid Sb‐based Halides towards Multiple Emissions
Authors: Li Bohan , Jin Jiance , Yin Meijuan , Zhang Xinlei , Molokeev Maxim S. , Xia Zhiguo , Xu Yan 
Published: October 2022

AbstractZero‐dimensional (0D) metal halides have drawn increasing attention due to the attractive structure dependent photoluminescence (PL) properties. Here, we report two new 0D organic–inorganic hybrid Sb‐based halides, (MTP)6SbBr6Sb2Br9⋅H2O (MTP=Methyltriphenylphosphonium, crystal 1) and (MTP)2SbBr5 (crystal 2), featuring a reversible structural phase transformation and tunable orange and red emissions upon dehydration and rehydration of H2O molecules. Intriguingly, a subsequent heat treatment further enables the formation of glassy state (MTP)2SbBr5 (glass 3) with near‐infrared luminescence, moreover, a sequential reverse phase transformation from glass 3 to crystal 2 and 1 is triggered by acetonitrile and water vapor stepwise. The anti‐counterfeiting demo based on the tunable and reversible PL switching is finally achieved and thus the phase structure engineering in 0D metal halides expands their multiple applications in optical fields.
Hierarchical Supramolecular Self‐Assembly: Fabrication and Visualization of Multiblock Microstructures**
Authors: Shi Xiujuan , Zhang Jun , Liu Junkai , Zhao Xueqian , Wang Haoran , Wei Peifa , Zhang Xiaodong , Ni Xin‐Long , Sung Herman H.‐Y. , Williams Ian D. , Ng Wai Kit , Wong Kam Sing , Lam Jacky W. Y. , Wang Lin , Jin Honglin , Tang Ben Zhong 
Published: October 2022

AbstractDue to the fast dynamics and re‐equilibration of supramolecular self‐assembly, bottom‐up molecular strategies to fabricate well‐defined and controllable multiblock structures are rare. Herein, we propose a new concept for fabrication of fluorescent multiblock microcolumns containing 1 to 7 blocks via hierarchical supramolecular self‐assembly based on cucurbit[8]uril (CB[8]), NaBr and an AIEgen guest. Through the complexation between CB[8] and different numbers of AIEgen guests (2, 1, 0), the competitive displacement caused by the binding of the sodium cation to the CB[8] portal, and the reversible assembly of positively charged guests in salt solutions, one‐pot hierarchical supramolecular self‐assembly is realized. The molecular structure of each block is analyzed by single‐crystal X‐ray diffraction. The AIEgen enables the self‐assembly of multiblocks to be visualized, understood, and regulated.