bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Computational Study, and Anticonvulsant Activity of Newly Synthesized 2-aminobenzothiazole Derivatives
Authors: Mishra Arun Kumar , Singh Vachan , Kumar Arvind , Singh Harpreet 
Published: April 2022

Background:Despite the fact that anticonvulsant drugs targeting multiple targets have been used in the health center, their effectiveness and tolerability in the treatment of seizures have not improved much. As a result, innovative anticonvulsant medicines are still needed urgently to overcome the significant toxicity of currently existing medications.Objective:This study aimed to synthesize 2-aminobenzothiazole derivatives as anticonvulsant agents, compute physicochemical parameters, and conduct a docking investigation.Methods:Condensing 4-(2-(benzo[d]thiazole-2-ylamino) acetamido) benzoyl chloride with substituted phenols in acetone in anhydrous potassium carbonate in the presence of potassium iodide in dry acetone yielded benzothiazole derivatives. IR and NMR spectroscopy were used to characterize the structures of freshly synthesized substances. To estimate their drug-like candidates, a number of molecular attributes of these derivatives were computed. The carbonic anhydrase enzyme was used to perform molecular docking on these synthesized compounds. The synthetic compounds were tested for biological activity, such as anticonvulsant activity and enzyme inhibitor activity for carbonic anhydrase.Results:The findings showed that V-5 (4-chlorophenyl 4-(2-(benzo[d]thiazol-2-ylamino)acetamido)benzoate) had the strongest anticonvulsant effect out of all the eight target compounds.Conclusion:The outcome of this research was that V-5 could be a promising new lead molecule for the development of anticonvulsant drugs.
Artificial Intelligence in Pharmacovigilance and COVID-19
Authors: Bhardwaj Kamini , Alam Rabnoor , Pandeya Ajay , Sharma Pankaj Kumar 
Published: April 2022

:The history of pharmacovigilance started back 169 years ago with the death of a 15- year-old girl, Hannah greener. However, the Thalidomide incident of 1961 brought a sharp change in the pharmacovigilance process, with adverse drug reaction reporting being systematic, spontaneous, and regulated timely. Therefore, continuous monitoring of marketed drugs was essential to ensure the safety of public health. Any observed adverse drug reaction detected by signals was to be reported by the health profession. Moreover, signal detection became the primary goal of pharmacovigilance based on reported cases. Among various methods used for signal detection, the Spontaneous Reporting System was most widely preferred; although, it had the limitation of "under- reporting”. Gradually, the World Health Organization collaborating centre and “Uppsala Monitoring Centre” were established in 1978 for international monitoring of drugs. The centre was responsible for operating various databases like vigiflow, vigibase, vigilyze, and vigiaccess. Recently, huge data could be generated through spontaneous reporting linked with computational methods, such as Bayesian Framework, E-Synthesis.:Furthermore, drug safety surveillance at an early stage prior to the official alerts or regulatory changes was made possible through social media. In addition, India created a National Pharmacovigilance Program, and Schedule Y of the Drug and Cosmetic Act 1945 was reviewed and amended in 2005. The collaboration of Information Technology and Pharmaceutical Company can further enhance the awareness regarding artificial intelligence in pharmacovigilance, which was in its infancy until 2017. Artificial intelligence helps improve the quality and accuracy of information much quickly.
Coronavirus Disease 2019 and Hypertension: How Anti-hypertensive Drugs Affect COVID-19 Medications and Vice Versa
Authors: Roozbeh Jamshid , Doostkam Aida , Hosseinpour Alireza , Iravani Kamyar , Malekmakan Leila , Haghpanah Abdolreza , Masjedi Fatemeh , Karimi Zeinab , Rouzbeh Hossein 
Published: April 2022

Background:As a medical problem, hypertension is one of the most common disorders in cardiovascular disease. High blood pressure has been identified as one of the most familiar risk factors for the ongoing COVID-19 pandemic. We planned to explore the possible interactions between anti-hypertensive agents and drugs targeting SARS-CoV-2 with broad investigations of these medications' mechanism of action and adverse effects.Method:Two co-authors searched the electronic databases (PubMed, Scopus, and Google Scholar) to collect papers relevant to the subject. The keywords searched were angiotensin-converting enzyme inhibitors (ACEI), angiotensin-II receptor blockers (ARBs), sympatholytic drugs (alpha-1 blockers, beta-blockers), vasodilators (calcium channel blockers, nitrates, and hydralazine), diuretics, chloroquine, hydroxychloroquine, lopinavir/ritonavir, remdesivir, favipiravir, interferons, azithromycin, anti-cytokine agents, glucocorticoids, anticoagulant agents, nitric oxide, and epoprostenol.Results:QT prolongation, arrhythmia, hypokalemia, hypertriglyceridemia are the most dangerous adverse effects in the patients on COVID-19 medications and anti-hypertensive drugs.Conclusion:This review emphasized the importance of the potential interaction between drugs used against COVID-19 and anti-hypertensive agents. Therefore, caution must be exercised when these medications are being used simultaneously.
Trauma & Disordered Eating in Adolescents: A Review
Authors: Tocco Maria A. , Mohiuddin Sarah S. 
Published: April 2022

Purpose of Review:
Trauma exposure is common, with more than half of
children and adolescents experiencing at least one traumatic event prior to
adulthood. Although diagnoses of eating disorders are less prevalent, the majority
of adolescents report engaging in disordered eating behaviors. The association
between childhood trauma exposure and disordered eating behaviors has been well
documented in adults, however, less is known about this association in adolescents.
This review summarizes the literature that exists on the adolescent population.

Recent Findings:
Multiple large-scale studies have demonstrated that adolescents
who have been exposed to trauma are more likely to engage in disordered eating
behaviors. This association was shown to exist in both sexes, although there
appears to be a higher prevalence reported in girls. There do not appear to be
significant racial or cultural factors that contribute to this association. The
experience of sexual trauma, increased trauma severity, and repeat victimization
confer an increased risk of engaging in disordered eating behaviors. There are
multiple mediators that play a role in the development of disordered eating
following a traumatic experience.
Synthesis of Oxadiazole, Imidazole, Benzimidazole, Cyclohexano
Analogues of 1, 5-benzodiazepines Through Phenoxyl/Phenylamino Linkage
Authors: Mir Mohd Amin 
Published: April 2022

Aim:
To synthesize Oxadiazole, Imidazole, Benzimidazole, and Cyclohexano Analogues of 1, 5-benzodiazepines through phenoxyl/phenylamino linkage

Background:
It is worthwhile to mention that Imidazoles, benzimidazoles, oxadiazoles, are analysed extensively mainly as per their ready availability, broad chemical reactivity, and wide spectrum of biochemical activities, like antimicrobial, anti-inflammatory, antitumor, anticonvulsant drugs, anti-tubercular medicines, and having anti-HIV effect etc.

Objective:
The Oxadiazole, Imidazole, Benzimidazole derivatives were synthesized via Cyclohexano Analogues of 1, 5-benzodiazepines through phenoxyl/phenylamino linkage.

Method:
The characteristic drift of our interest towards these molecules prompted us to think about the structural modification of [1, 5]-benzodiazepine compound by incorporating on its 2-position imidazole, benzimidazole, oxadiazole, nuclei through an aminophenyl or phenoxyl bridge to synthesize these novel heterocyclic analogues of 1, 5-benzodiazepines.

Results:
These derivatives have been analysed by various spectrophometric techniques like UV, IR, NMR, and MS. The synthesis of these compounds via the mentioned methods are unique as Cyclohexano Analogues of 1, 5-benzodiazepines through phenoxyl/phenylamino is a totally new way of synthesis. The derivatives can be analysed for various properties in chemistry and pharmacology, as their parent compounds has many pharmacological properties.

Conclusion:
The synthesis of these types of compounds does provide a new hope to medicinal and pharmaceutical industries. Therefore further efforts should be taken into consideration for their synthesis and analysis of their medicinal properties.
A Review of Nanoparticles Characterization Techniques
Authors: Wadhwa Pankaj , Sharma Supriya , Sahu Sanjeev , Sharma Ajit , Kumar Deepak 
Published: April 2022

Abstract:
Nanoparticles (NPs) are small materials of sizes 1 to 100 nm and can be divided into different
categories according to their properties, shapes, or sizes. They can be classified as metal nanoparticles,
carbon-based nanoparticles, semiconductor nanoparticles, ceramics nanoparticles, polymeric
nanoparticles, and lipid-based nanoparticles. The basic characteristics used while characterizing the
nanoparticles are morphology, size, surface charge, and optical properties. SEM, environmental SEM
(ESEM), tip-enhanced Raman spectroscopy (TERS), scanning tunneling microscopy (STM), and
TEM are used to study the topography and morphology of nanoparticles. Spectral analysis is employed
to check optical properties, while X-ray crystallography (XRD), energy-dispersive X-ray
(EDX) spectroscopy, Fourier transform infrared spectroscopy (FTIR), and fluorescence correlation
spectroscopy (FCS) are used for learning the fundamental properties of nanoparticles (NPs). This review
will focus on the utilization of these techniques in the characterization of nanoparticles.
A Social Media–Based Diabetes Intervention for Low-Income Mandarin-Speaking Chinese Immigrants in the United States: Feasibility Study
Authors: Hu Lu , Islam Nadia , Trinh-Shevrin Chau , Wu Bei , Feldman Naumi , Tamura Kosuke , Jiang Nan , Lim Sahnah , Wang Chan , Bubu Omonigho M , Schoenthaler Antoinette , Ogedegbe Gbenga , Sevick Mary Ann 
Published: April 2022

Background
Chinese immigrants bear a high diabetes burden and face significant barriers to accessing diabetes self-management education (DSME) and counseling programs.

Objective
The goal of this study was to examine the feasibility and acceptability and to pilot test the potential efficacy of a social media–based DSME intervention among low-income Chinese immigrants with type 2 diabetes (T2D) in New York City.

Methods
This was a single group pretest and posttest study in 30 Chinese immigrants with T2D. The intervention included 24 culturally and linguistically tailored DSME videos, focusing on diabetes education and behavioral counseling techniques. Over 12 weeks, participants received 2 brief videos each week via WeChat, a free social media app popular among Chinese immigrants. Primary outcomes included the feasibility and acceptability of the intervention. Feasibility was evaluated by recruitment processes, retention rates, and the video watch rate. Acceptability was assessed via a satisfaction survey at 3 months. Secondary outcomes, that is, hemoglobin A1c (HbA1c), self-efficacy, dietary intake, and physical activity, were measured at baseline, 3 months, and 6 months. Descriptive statistics and paired 2-sided t tests were used to summarize the baseline characteristics and changes before and after the intervention.

Results
The sample population (N=30) consisted of mostly females (21/30, 70%) who were married (19/30, 63%), with limited English proficiency (30/30, 100%), and the mean age was 61 (SD 7) years. Most reported an annual household income of <US $25,000 (24/30, 80%) and a high school education or less (19/30, 63%). Thirty participants were recruited within 2 months (January and February 2020), and 97% (29/30) of the participants were retained at 6 months. A video watch rate of 92% (28/30) was achieved. The mean baseline HbA1c level was 7.3% (SD 1.3%), and this level declined by 0.5% (95% CI –0.8% to –0.2%; P=.003) at 6 months. The mean satisfaction score was 9.9 (SD 0.6) out of 10, indicating a high level of satisfaction with the program. All strongly agreed or agreed that they preferred this video-based DSME over face-to-face visits. Compared to baseline, there were significant improvements in self-efficacy, dietary, and physical activity behaviors at 6 months.

Conclusions
This pilot study demonstrated that a social media–based DSME intervention is feasible, acceptable, and potentially efficacious in a low-income Chinese immigrant population with T2D. Future studies need to examine the efficacy in an adequately powered clinical trial.
Predicting survival for hepatic arterial infusion chemotherapy of unresectable colorectal liver metastases: Radiomics analysis of pretreatment computed tomography
Authors: Liu Peng , Zhu Haitao , Zhu Haibin , Zhang Xiaoyan , Feng Aiwei , Zhu Xu , Sun Yingshi 
Published: April 2022

Abstract

Objective
Hepatic arterial infusion chemotherapy (HAIC) is an effective treatment for advanced unresectable colorectal cancer liver metastases (CRLM). This study was conducted to predict the efficacy of HAIC in patients with unresectable CRLM by radiomics methods based on pretreatment computed tomography (CT) examinations and clinical data.

Materials and Methods
A total of 63 patients were included in this study (41 in the training group and 22 in the validation group). All these patients underwent CT examination before HAIC. During the follow-up period, CT scans and laboratory examinations were performed regularly. Eighty-five radiological features were extracted from the regions of interest (ROIs) of CT images using the PyRadiomics program. The t-test and correlation were applied to select features. These features were analyzed using LASSO-Cox regression, and a linear model was developed to predict overall survival (OS).

Results
After reducing features by t-test and correlation test, seven features remained. After LASSO-Cox cross-validation, four features remained at λ = 0.232. They were gray level co-occurrence matrix (GLCM), gray level run length matrix (GLRLM), neighborhood gray tone difference matrix (NGTDM), and the location of the primary tumor. The C-index was 0.758 in the training group and 0.743 in the test group. Nomograms predicting 1-, 2-, and 3-year survival were established.

Conclusion
Our study demonstrates that a radiomics approach based on pretreatment CT texture analysis has the ability to predict early the outcome of HAIC in patients with advanced unresectable colorectal cancer with a high degree of accuracy and feasibility.
A utilização o Google sala de aula em sala: uma ferramenta complementar para o Ensino de Ciências
Authors: Carvalho Denis Ribeiro 
Published: April 2022

O presente trabalho traz reflexões e discussões sobre a utilização das Tecnologias Digitais de Informação e Comunicação (TIC’s) em sala de aula no processo de ensino-aprendizagem em uma Escola de periferia na cidade de Alegrete/RS. A pesquisa foi desenvolvida em turmas de 7º, 8º e 9º anos do ensino fundamental através do Programa Institucional de Bolsas de Iniciação à Docência (Pibid), por meio de um recurso digital, chamado de “Google Classroom”, em sua tradução para a língua portuguesa: “Google Sala de Aula”. A inserção de tecnologia em sala de aula, nos permite criar um ambiente de aprendizagem interativo, compartilhando materiais didáticos de forma dinâmica, no ensaio de práticas educacionais. Na tentativa de se aproximar da realidade dos alunos e simultâneamente oferecer um ensino atrativo se apropriando dos recursos disponíveis e que incentivem uso de propostas metodológicas alternativas.
Política de Arte e Cultura do Instituto Federal de Educação, Ciência e Tecnologia Farroupilha - IFFar
Authors: Batalha Denise Valduga , Gindri Haigert Cynthia , Lunardi Raquel 
Published: April 2022

Este trabalho se propõe a apresentar a Política de Arte e Cultura do Instituto Federal de Educação, Ciência e Tecnologia Farroupilha - IFFar, a partir da retrospectiva das atividades desenvolvidas pela instituição no que concerne aos documentos norteadores elaborados para garantir um espaço institucional de diálogo, formação, pesquisa e fomento de ações de Arte e Cultura. A Política de Arte e Cultura busca proporcionar aos servidores e estudantes do Instituto Federal Farroupilha uma formação crítica e dialógica em extensão universitária, através de ações culturais desenvolvidas em diferentes programas, projetos, cursos e eventos institucionais de intercâmbio cultural e de aprimoramento da formação. Considera-se que planejar, coordenar, articular e executar as políticas culturais do IFFar, pela elaboração de estratégias de atividade cultural institucional, visam a construir ações conjuntas com a sociedade e com o poder público para a emancipação das comunidades por meio da cultura, reconhecendo que a criação e a produção cultural são formas essenciais e privilegiadas de aquisição, expressão e construção do conhecimento, além de ser direito universal e inalienável da cidadania.
Dramaturgi Bakaua dalam Masyarakat Minangkabau: Studi atas Ritual Tolak Bala Dengan Perspektif Victor Turner
Authors: Pramayoza Dede 
Published: April 2022

This article discusses the Bakaua ritual in the Minangkabau community, which is held in several places in the Sijunjung area. The Bakaua ritual is a ritual of expressing gratitude, as well as a ritual of rejecting reinforcements. Using a qualitative approach, the aim of this research is to find the structure as well as the anti-structure of the Bakaua ritual, in order to find out its symbolic meaning. The ritual structure is understood as a dramaturgy, by viewing ritual as a form of social drama. Research data were collected from various written sources for further analysis using an interpretive approach, based on the ritual concepts of Victor Turner. The results showed that the Bakaua ritual as a ritual of rejecting reinforcements had a meaning as a symbol of mutual cooperation and harmony. A symbol, which reflects the belief of the supporting communitas in a shared identity that is still preserved, as a community, existentially, normatively, and ideologically.Keywords: Bakaua; ritual; tolak bala; Minangkabau; dramaturgyAbstrakArtikel ini membahas tentang ritual Bakaua dalam Masyarakat Minangkabau, yang tergelar di beberapa tempat di kawasan Sijunjung. Ritual Bakaua merupakan suatu ritual ungkapan rasa syukur, sekaligus ritual tolak bala. Menggunakan pendekatan kualitatif, tujuan penelitian adalah untuk menemukan struktur sekaligus anti struktur dari ritual Bakaua tersebut, untuk seterusnya menemukan makna simboliknya. Struktur ritual dipahami sebagai suatu dramaturgi, dengan memandang ritual adalah suatu bentuk drama sosial. Data penelitian dikumpulkan dari berbagai sumber tertulis untuk selanjutnya dianalisis dengan pendekatan interpretatif, berdasarkan pada konsep-konsep ritual dari Victor Turner. Hasil penelitian menunjukkan bahwa ritual Bakaua sebagai suatu ritual tolak bala memiliki makna sebagai suatu simbol gotong royong dan kerukunan. Suatu simbol, yang mencerminkan keyakinan masyarakat pendukungnya pada identitas bersama yang masih terpelihara, sebagai suatu communitas, baik secara eksistensial, normatif, maupun ideologis.Kata Kunci: Bakaua; ritual; tolak bala; Minangkabau; dramaturgi
Changing Pattern of Bacteriological Profile, Antimicrobial Resistance and Mortality in Neonatal Sepsis in a Developing Country: A Retrospective Study
Authors: Saha Anindya Kumar , Tiwari Abhishek Kumar , Chattopadhyay Pinaki , Mukherjee Suchandra , Saha Bijan 
Published: April 2022

Introduction: Neonatal sepsis is one of the major contributors of mortality and morbidity among neonates. Irrational and overuse of antibiotics have led to an increase in antimicrobial resistance. This study was undertaken to investigate the bacteriological profile, antimicrobial resistance and predictors of mortality among blood culture-positive cases of neonatal sepsis.
Methods: Demographic and bacteriological data were collected from electronic and manual case records. Automated BACTEC 9050 system using Peds Plus Vial was used for blood culture. Multidrug resistance was defined as a resistance to any three of five antibiotic classes like aminoglycoside, carbapenem, extended spectrum cephalosporins, fluoroquinolones and piperacillin.
Results: Among 7180 admitted neonates, 433 (6.03%) were blood culture positive with early onset sepsis (EOS) in 50.1% of cases. Gram negative bacteria was the causative organism in 371 (85.7%) babies with klebsiella being the commonest pathogen (43.6%). The pathogen mix of early onset and late onset sepsis was similar and 90% of gram negative isolates were resistant to penicillin group. Multi drug resistance (MDR) was found in 51.2% of the gram negative organisms. EOS (Odds ratio 1.99; 95% confidence interval, 1.29-3.05) and MDR (Odds ratio 2.07; 95% confidence interval, 1.77-4.12) were independently associated with neonatal death due to sepsis.
Conclusions: Gram-negative pathogens, specifically klebsiella accounted for a huge burden of neonatal sepsis. EOS and MDR were found to be independent predictors of death due to such sepsis. This study calls for multicentric studies on early onset neonatal infection and its relationship with pathogenic maternal flora.
РОЗРОБКА ПОКРИТТІВ ДЛЯ РЕГЕНЕРАЦІЇ ВУЗЛІВ ПОЖЕЖНОЇ ТЕХНІКИ ТА ПРОТИПОЖЕЖНОГО ОБЛАДНАННЯ
Authors: Berezhanskyi T. , Pashechko M. 
Published: April 2022

Сьогодення диктує нові правила та потребує від суспільства постійної готовності до нових викликів – при-родних та техногенних загроз. Техногенне суспільство, технології в цілому швидко розвиваються. Природні явища: глобальне потепління, забрудненість екосистем та ін. зумовлюють природні катаклізми, які трапляються все частіше. Це потребує постійної готовності до захисту населення в разі виникнення надзвичайних ситуацій. Реалізацію функції держави, спрямованої на захист населення, територій, навколишнього природного се-редовища та майна від надзвичайних ситуацій природного та техногенного характеру та ліквідацію їх наслідків покладено, в першу чергу, на пожежно-рятувальні підрозділи служби цивільного захисту України.Зрозуміло, що існує ряд чинників, які впливають на ефективність виконання пожежно-рятувальними підрозділами своїх функцій, таких як: організація роботи підрозділів та служби цивільного захисту в цілому, індивідуальна та колективна теоретична і практична підготовка, а також багато інших, серед яких і технічне за-безпечення. Якісне та надійне технічне забезпечення підрозділів цивільного захисту України є запорукою ефек-тивної роботи служби пожежно-рятувальних підрозділів і як наслідок безпеки населення України.Тому удосконалення, підвищення надійності, ресурсу роботи та універсальності пожежного та аварійно-рятувального обладнання є актуальним завданням сьогодення.Зносостійкі евтектичні покриття системи Fe-Mn-C-B-Si леговані Cr виконані у вигляді порошкових дротів відзначаються від 1,8 до 10 разів зносостійкістю від матеріалів серійного виробництва. Ці матеріали окрім високої зносостійкості також характеризуються хорошими зварювальними властивостями, що дає змогу наносити їх на деталі пожежної техніки та аварійно-рятувального обладнання за допомогою методів електродугового, плазмо-вого наплавлення та методом напилення, а також іншими перспективними методами. Методи регенерації деталей пожежної техніки та аварійно-рятувального обладнання евтектичними покриттями дають змогу продовжити ре-сурс роботи вузлів та підвищити їх зносостійкість.Розроблено склад зносостійкого покриття на основі евтектичного сплаву системи Fe-Mn-C-B-Si легованого Cr, який відзначається найкращою зносостійкістю серед досліджуваних взірців. Покриття характеризується хо-рошими зварювальними властивостями, тому його можна рекомендувати для регенерації та продовження терміну експлуатації вузлів і деталей пожежної техніки та обладнання.