bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Random Reversible Watermarking Schefme for Relational Data
Authors: Liu Qiang , Xian Hequn , Cao Xiuping 
Published: April 2022

Abstract
In the era of Big Data, relational data is at risk of piracy and misuse when distributed, shared and used. The use of digital watermarking technology is a reliable way to protect the copyright of relational data. In order to protect the copyright of relational data and recover the original data, many reversible watermarking schemes have been proposed in recent years, but most of them cannot extract the watermark information completely under severe attacks. To address this problem, a random-ized reversible watermarking scheme is proposed.Watermark embedding algorithm, watermark integrity checking algorithm, watermark detection algorithm and data recovery algorithm were designed. The watermark capacity is increased by embedding multiple watermarks in selected tuples, and the randomness of the watermark information distribution is increased by embedding unequal proportions of watermarks in different tuples. In extracting the watermark, the attacked bits are discarded to improve the accuracy of watermark detection. In addition, only a partition with complete watermark information is selected for watermark extraction. This not only improves the speed of watermark extraction, but also avoids the risk of key leakage from other partitions. The experimental results show that the complete watermark information can be extracted even when more than 90% of the tuples are under attack.
Study on the protective effect and mechanism of Neutralizing IL-17A with Secukinumab on severe sepsis model rats
Authors: Wang Xingsheng , Zhang Xinxin , Sun Li , Li Yun , Gao Guangsheng 
Published: April 2022

Abstract
In this study, the rat model of severe sepsis was established by caecal ligation and perforation to observe the protective effect of the specific neutralizing antibody of IL-17A, Secukinumab, on rats with severe sepsis and explore its molecular mechanism. At present, a large number of studies have confirmed the important role of IL-17A in sepsis, but the role of secukinumab in sepsis has not been studied. The results showed that the survival rate of the rats with severe sepsis was significantly improved, the pathological changes of lung tissue were significantly reduced, and the wet/dry weight ratio of lung tissue was decreased. It also significantly inhibited the inflammatory response of lung tissue induced by severe sepsis and inhibited the activation of the IKBα/NFκB inflammatory pathway. Our results suggest that neutralizing IL-17A, secukinumab inhibits the activation of the IKBα/NFκB inflammatory pathway, reduces the gene expression of pathway-related inflammatory cytokines, and thus reduces the levels of inflammatory cytokines in lung tissue and plasma, thereby alleviating lung tissue injury and improving systemic inflammation in rats with severe sepsis. This may provide new ideas for the treatment of sepsis.
Packet loss concealment method based on hidden Markov model and decision tree for AMR-WB codec
Authors: Gueham Tarek , Merazka Fatiha 
Published: April 2022

Abstract
In this paper, we introduce hidden Markov model (HMM) based packet loss concealment (PLC) methods and discuss the impact of Markovian assumptions on the performance of these models. We also present a new PLC method, implemented on the G.722.2 codec, which relies on the HMM and Decision Tree (DT), namely HMDT architecture, to enhance the perceptual quality of Voice over Internet Protocol (VoIP) communications under severe packet loss conditions. The proposed method is a receiver-based model that tracks the statistical evolution of speech signals through HMM and uses the DT architecture to predict/estimate accurately the lost speech packets by exploiting the surrounding received speech packets. Objective and subjective metrics are used to evaluate the performance of the proposed method. Test results show that our proposed method enhances considerably the speech quality of the reconstructed speech signal and produces a more natural speech variation compared to conventional PLC methods.
Exploration of the molecular mechanism of the bone protective effect activated by Si-Wu- Tang in ApoE -/- mice fed a high-fat diet through network pharmacology analysis combined with in vivo experiments
Authors: Yang Jiadi , Shi Danning , Zhang Zeye , Zhang Meng , Yan Qian , He Yueshuang , Liu Jiao , Zhao Piwen 
Published: April 2022

Abstract
Background
Bone protective effect of Si-Wu-Tang (SWT), a classical prescription of traditional Chinese medicine, is verified in clinical for thousand years. However, its mechanisms were still unclear. This study aims to investigate the molecular mechanism in ApoE -/- mice fed a high-fat diet combining network pharmacology and in-vivo experiments.
Methods
Femurs were collected from 6 ~ 8-week-old female ApoE-/- C57BL/6J mice (n = 12, 18–22 g) and their age-matched wild-type (WT) littermates C57BL/6J mice (n = 6, 18–20 g). They were divided into 3 groups: the control, SWT and model groups. Serum levels of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured by the serum biochemical index. HE staining and immunohistochemistry analysis were performed to observe the pathological tissue structure and the location and expression level of targets from the pathway screened out by the network pharmacology method. Western blot (WB) and RT-PCR analyses were performed to detect the expression levels of target proteins and mRNAs, respectively.
Results
The results of the network pharmacology analysis showed that the mechanism of SWT in treating osteopenia was closely related to the oestrogen receptor (ER) signalling pathway. In vivo experiments indicated that, compared with control group, the distribution of bone trabeculae was sparse, and the bone density decreased. The levels of HDL-C and LDL- C in the serum of the model group increased significantly (p < 0.01). The expression of GPER, PI3K, AKT and BCL-2 in the bone tissue of the model group decreased, and P53, BAX, ERα and ERβ were upregulated. Compared with the model group, the body mass of the SWT group increased slowly. The bone density and the distributions of bone trabeculae both increased. The expression of ERα, ERβ, GPER, PI3K, AKT and BCL-2 increased. The decreased expression of apoptotic genes, including P53 and BAX, was observed.
Conclusion
SWT significantly reduced bone loss in ApoE -/- mice fed a high-fat diet. An important mechanism might be that SWT could activate the PI3K/AKT signalling pathway mediated by ER and then inhibit apoptosis-related proteins to exert bone protective effects.
Multiple UAVs Three-Dimensional Navigation Using a Hybrid Optimization Algorithm
Authors: Jain Upma , Dewangan Ram Kishan , Tiwari Shailendra , Prakash Jay 
Published: April 2022

Abstract
This paper aims to propose a hybrid approach for multiple UnmannedAerial Vehicle navigation. This is an NP-hard problem since the robots have to find the optimal safe path without colliding with other robots and obstacles in three-dimensional search space. The proposed approach enhances the exploration capabilities of the whale optimization algorithm and then hybrid this improved whale optimization algorithm with the sine cosine algorithm to improve the overall exploitation capabilities. The efficiency of the proposed hybrid approach is compared with other meta-heuristic algorithms for multi-UAV navigation. Results obtained through simulation ensure the validity of the proposed approach.
Comparison of femoral neck system versus dynamic hip system blade for the treatment of femoral neck fracture in young patients: A retrospective study
Authors: Ge Zilu , Xiong Wei , Wang Dong , Tang Yunfeng , Fang Qian , Wang Limin , Zhang Zhen , Lin Wei , Wang Guanglin 
Published: April 2022

Abstract
Background
Femoral neck fracture is a common fracture in orthopedic practice. This study aimed to compare the clinical outcomes between the femoral neck system and dynamic hip system blade for the treatment of femoral neck fracture in young patients.
Methods
This retrospective study included 43 and 52 patients who underwent treatment for femoral neck fracture with the femoral neck system and dynamic hip system blade, respectively, between August 2019 and February 2020. Operative indexes, including operation duration, blood loss, incision length, postoperative complications (femoral neck shortening, non-union, screw pull-out, femoral head necrosis), and Harris scale scores were recorded and analyzed.
Results
Compared to that with the dynamic hip system blade, the femoral neck system showed significantly less operation duration (femoral neck system vs dynamic hip system blade: 47.09 ± 9.19 vs 52.90 ± 9.64, P = 0.004), less blood loss (48.53 ± 10.69 vs 65.31 ± 17.91, P < 0.001), and shorter incision length (4.04 ± 0.43 vs 4.93 ± 0.53, P < 0.001). Femoral neck shortening was significantly lower with the femoral neck system than with the dynamic hip system blade (3.93 ± 2.40, n = 39 vs 5.22 ± 2.89, n = 44, P = 0.031). No statistical differences were observed between the two groups in nonunion, screw pull-out, and femoral head necrosis. In addition, the latest follow-up Harris scale score was significantly higher with the femoral neck system than with the dynamic hip system blade (92.3 ± 4.5 vs 89. 9 ± 4.9, P = 0.015).
Conclusion
The femoral neck system results in less trauma, less femoral neck shortening, and better hip joint function than the dynamic hip system blade for the treatment of femoral neck fracture in young patients.
Trial registration:
The retrospective study was approved by the Ethical Committee of West China Hospital, Sichuan University (No. 20211132)
A robust framework to investigate the reliability and stability of explainable artificial intelligence markers of Mild Cognitive Impairment and Alzheimer’s Disease
Authors: Lombardi Angela , Diacono Domenico , Amoroso Nicola , Biecek Przemyslaw , Monaco Alfonso , Bellantuono Loredana , Pantaleo Ester , Logroscino Giancarlo , Blasi Roberto , Tangaro Sabina , Bellotti Roberto 
Published: April 2022

Abstract
In clinical practice a number of standardized neuropsychological tests have been designed to assess and monitor the neurocognitive status of patients with neurodegenerative diseases such as Alzheimer’s disease. Important research efforts have been devoted so far to the development of multivariate machine learning models that combine the different test indexes to predict the diagnosis and prognosis of cognitive decline with remarkable results. However, less attention has been devoted to the explainability of these models. In this work, we present a robust framework to (i) perform a threefold classification between healthy control subjects, individuals with cognitive impairment and subjects with dementia using different cognitive indexes and (ii) analyze the variability of the explainability SHAP values associated with the decisions taken by the predictive models. We demonstrate that the SHAP values can accurately characterize how each index affects a patients’ cognitive status. Furthermore, we show that a longitudinal analysis of SHAP values can provide effective information on Alzheimer’s disease progression.
SARS-CoV-2 hijacks host cell genome instability pathways
Authors: Victor Joshua , Jordan Tristan , Lamkin Erica , Ikeh Kanayo , March Anthony , Frere Justin , Crompton Andrew , Allen Lindsay , Fanning James , Lim Won Young , Muoio Daniela , Fouquerel Elise , Martindale Rachel , Dewitt John , deLance Nicole , Taatjes Douglas , Dragon Julie , Holcombe Randall , Greenblatt Marc , Kaminsky David , Hong Jiyong , Zhou Pei , tenOever Benjamin , CHATTERJEE NIMRAT 
Published: April 2022

Abstract
The repertoire of coronavirus disease 2019 (COVID-19)-mediated adverse health outcomes has continued to expand in infected patients, including the susceptibility to developing long-COVID; however, the molecular underpinnings at the cellular level are poorly defined. In this study, we report that SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection triggers host cell genome instability by modulating the expression of molecules of DNA repair and mutagenic translesion synthesis. Further, SARS-CoV-2 infection causes genetic alterations, such as increased mutagenesis, telomere dysregulation, and elevated microsatellite instability (MSI). The MSI phenotype was coupled to reduced MLH1, MSH6, and MSH2 in infected cells. Strikingly, pre-treatment of cells with the REV1-targeting translesion DNA synthesis inhibitor, JH-RE-06, suppresses SARS-CoV-2 proliferation and dramatically represses the SARS-CoV-2-dependent genome instability. Mechanistically, JH-RE-06 treatment induces autophagy, which we hypothesize limits SARS-CoV-2 proliferation and, therefore, the hijacking of host-cell genome instability pathways. These results have implications for understanding the pathobiological consequences of COVID-19.
Comparative transcriptome analysis revealed omnivorous adaptation of the small intestine of Melinae
Authors: wang Lidong , zhang Honghai 
Published: April 2022

Abstract

Background
Mink fur is an important economic product, but the molecular mechanism of its color formation and fur development is still unclear. We used RNA-seq to analyze the skin transcriptome of young and adult minks with two different hair colors.
Result
The minks were made up of black adults (AB), white adults (AW), black juveniles (TB), and white juveniles (TW) (three each). We found that thirteen KRTAP genes and five signaling pathways (JAK-STAT signaling Pathway (cfa04630), Signaling pathways regulating pluripotency of stem cells (cfa04550), ECM-receptor interaction (cfa04512), Focal adhesion (cfa04510) and Ras signaling pathway (cfa04014)) were related to mink fur development through pair comparison and cross-screening among different subgroups. We also found a tyrosinase family (TYR, TYRP1, TYRP2) involved in mink hair color formation. The expression level of TYR in black young minks was higher than that in white young minks, but this phenomenon was not observed in adult minks.
Conclusion
Our study found significant differences in adult and juvenile mink skin transcriptome, which may shed light on the mechanism of mink fur development. At the same time, the skin transcriptome of black and white minks was also different, and the comparison was different by age, suggesting that the genes regulating hair color function in early childhood rather than adulthood. This study can provide molecular support for breeding mink coat color and improving fur quality.
Implementation of Sustainable Development by Cities and Businesses in Poland. Evolution of the Approach
Authors: Jastrzębska Ewa , Legutko-Kobus Paulina 
Published: April 2022

Adoption of the UN Sustainable Development Goals (SDG) in 2015 put the theoretical concept of sustainable development (SD) into practice. The goals kindled a vivid interest among Poland-based companies, too, especially large enterprises, which took them to the next level, and embedded them in their corporate strategies. Truth be told, Polish local governments started to implement SD much earlier, namely through Local Agendas 21 after the Second Earth Summit in Rio de Janeiro in 1992. The year 2015 was a pivotal moment for the development of the SD concept. Yet, in the opinion of many experts, 2020 was a major test for SDGs as the COVID-19 pandemic was exerting an adverse impact on the progress in their achievement. The study attempts to assess the approach of SD pioneers in Poland, both cities and companies, to the implementation of the concept in the first year of the pandemic. The text provides a critical analysis of the literature on the subject, web research, and authors’ empirical studies conducted among those cities and businesses in Poland that are considered the leading SD implementers. The conducted research demonstrated that most of these leaders (both cities and businesses) are acquainted with both SD and SDGs. In the period covered by analysis, there was a major growth in SD institutionalization. Both business and city representatives understand SD primarily in accordance with the definition framed in Agenda 2030. A stable majority of the surveyed cities and businesses believe that their approach to SD implementation has changed since the announcement of SDGs in 2015. The COVID-19 pandemic has not halted the implementation of SDGs, although in some cases, it has forced the surveyed implementers to revise their modus operandi.
Ecophilosophical and Ecopsychological Aspects of Sustainable Consumption and Lifestyle
Authors: Niedek Mikołaj 
Published: April 2022

The aim of the article is to outline the philosophical and psychological dimensions of a sustainable lifestyle based on responsible consumption. In the author’s opinion, moderate consumption and an ecologically balanced way of living should, for their durability, have a broader mental and worldview background. The article will present and compare the concepts of the eco-philosophy of Henryk Skolimowski and the ecopsychology of Theodore Roszak in terms of cognitive, ideological, and axiological propositions of these concepts that can form the motivating basis for responsible living on Earth. In the author’s opinion, apart from the economic dimension, the adoption of ecological ethics and of ecological sensitivity is crucial for the permanent rooting of sustainable consumption patterns in people's attitudes. Ecophilosophical and ecopsychological concepts can significantly help in this, contributing to human sensitivity to environmental issues related to the contemporary ecological crisis. The ecophilosophical and ecopsychological approach, in the author’s opinion, need each other because they use complementary perspectives and methods of building ecological awareness. In the process of environmental education and shaping sustainable life attitudes, they are equally necessary for the effectiveness of achieving the goals of education for sustainable development and promoting an environmentally responsible lifestyle in society.
The Preparation and Characterization of Emulsions with the Addition of
Tannic Acid and Gallic Acid
Authors: Kaczmarek-Szczepańska Beata , Kozak Anna , Zasada Lidia 
Published: April 2022

Background:
Polyphenols are natural compounds that show bioactive properties such as antioxidants. Thereby their application in the cosmetic industry may be considered.

Methods:
Tannic acid and gallic acid were used as an additive for emulsion preparation. The microscope observation was carried out to study the formation of the droplets. Also, the polyphenols release from the emulsion, its antioxidant activity and the color parameters were studied.

Results:
The results showed that the addition of polyphenols decreased the droplets’ diameter. Each emulsion showed antioxidant activity; however, the most effective was formulation containing 5% additive of gallic acid. The addition of tannic acid and gallic acid results in the change of color parameters of the studied formulation.

Conclusion:
In this study, we confirmed that tannic acid and gallic acid might be potentially used as additives in cosmetics formulations.
Safety and Monitoring of the Treatment with Disease-Modifying Therapies
(DMTs) for Multiple Sclerosis (MS)
Authors: Papazisis Georgios , Stamatellos Vasileios-Periklis 
Published: April 2022

Background:
Disease-Modifying Therapies (DMTs) for Multiple Sclerosis (MS) are widely
used given their proven efficacy in the relapsing form of the disease, while recently, Siponimod and
Ocrelizumab have been approved for the progressive forms of the disease. Currently, 22 diseasemodifying
drugs are approved by the FDA, while in 2012, only nine were present in the market. From
March 2019 until August 2020, six new drugs were approved. This rapid development of new DMTs
highlighted the need to update our knowledge about their short and long-term safety.

Objective:
A literature search was conducted using PUBMED and COCHRANE databases. Key journals
and abstracts from major annual meetings of Neurology, references of relevant reviews, and relative
articles were also manually searched. We prioritized systematic reviews, large randomized controlled
trials (RCTs), prospective cohort studies, and other observational studies. Special attention was
paid to guidelines and papers focusing on the safety and monitoring of DMTs.

Methods:
A literature search was conducted in PUBMED and COCHRANE databases. Also, we manually searched key journals and abstracts from major annual meetings of Neurology, references of relevant reviews, and relative articles. We prioritized systematic reviews, large randomized controlled trials (RCTs), prospective cohort studies, and other observational studies. Special attention was paid to guidelines and papers focusing on the safety and monitoring of DMTs. Data for oral (Sphingosine 1-phosphate (S1P) receptor modulators, Fumarates, Teriflunomide, Cladribine), injectables (Interferons, Glatiramer acetate, Ofatumumab), and infusion therapies (Natalizumab, Ocrelizumab, Alemtuzumab) are presented.

Conclusion:
Data for oral (Sphingosine 1-phosphate (S1P) receptor modulators, Fumarates, Teriflunomide,
Cladribine), injectables (Interferons, Glatiramer acetate, Ofatumumab), and infusion therapies
(Natalizumab, Ocrelizumab, Alemtuzumab) are presented.
PARENTS’ EMOTIONAL ATTITUDE TO CHILDREN OF SENIOR PRESCHOOL AGE
Authors: Реева Ольга Юрьевна 
Published: April 2022

Обсуждаются аспекты влияния показателей эмоциональных проявлений детско-родительских взаимоотношений и видов родительского воздействия в семьях, воспитывающих старших дошкольников.Рассмотрены виды родительского отношения и особенности эмоциональных проявлений родителей при выстраивании детско-родительского взаимодействия. Приведен анализ взаимосвязей видов родительского отношения с показателями эмоциональной составляющей детско-родительских взаимоотношений, включающей когнитивный и поведенческий компоненты. Сделан вывод, что социально одобряемые проявления родительства усиливают состояния волнения и тревоги за детей, ведут к чрезмерному контролю и симбиотическим отношениям.Выявлен и рассмотрен комплекс характеристик, описывающий эмоциональные проявления родителей, способствующий преобразованию симбиотических отношений и авторитарного контроля детей старшего дошкольного возраста в гармоничные партнерские отношения, способствующие формированию самостоятельной личности.
Aspects of the influence of indicators of emotional manifestations of child-parent relationships and types of parental influence in families raising older preschoolers are discussed.The types of parental relationship and the features of emotional manifestations of parents in building child-parent interaction are considered. The analysis of the interrelationships of the types of parental relationship with the indicators of the emotional component of the parent-child relationship, including cognitive and behavioral components, is given.The analysis of the results included: the study of parental attitude as a social component; features of cognitive and behavioral components of the emotional side of child-parent interaction; correlation analysis using the r-Spearman correlation coefficient to identify the relationship of indicators of parental attitude with indicators of the emotional side of child-parent interaction.We concluded that socially approved manifestations of parenthood increase states of excitement and anxiety for children, lead to excessive control and symbiotic relationships.A set of characteristics describing the emotional manifestations of parents, contributing to the transformation of symbiotic relationships and authoritarian control of older preschool children into harmonious partnerships that contribute to the formation of an independent personality, is identified and considered. It is shown that an optimal level of parental empathy in relationships with older preschool children favorable for their psychic development exists.