bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental assessment of the impact of high acoustic power ultrasound diagnostics on animal eyes
Authors: Zaitsev M. S. , Kiseleva T. N. , Lugovkina K. V. , Balatskaya N. V. , Jani E. V. , Seliverstova K. E. 
Published: September 2022

Purpose: to study the impact of diagnostic ultrasound of high acoustic power on animal eye tissues in the experiment.Material and methods. 46 Chinchilla rabbits (92 eyes) were divided into the main group of 38 rabbits (76 eyes) and the control group of 8 rabbits (16 intact eyes). Animals of the main group were exposed for 30 minutes, through closed eyes, to high-intensity ultrasound (MI 0.9–1.0, TI 1.5–2.0, Ispta.3 50 mW/cm2) by colour Doppler imaging and pulsed Doppler. All animals of this group had corneal thickness measured by optical coherence tomography (OCT) before and immediately after exposure to ultrasound (20 rabbits) and also 2 weeks later (18 rabbits). During the same time span, the content of heat shock proteins HSP27 (HSPB1), HSP60 (HSPD1) and inflammatory mediators: monocytic chemotactic protein-1 (MCP-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) in blood serum and vitreous was determined. Histopathological examinations of the enucleated eyes of rabbits with morphological and morphometric assessment of retinal tissues were performed on the 1st day and 2 weeks after exposure to ultrasound.Results. Immediately after ultrasound exposure and 2 weeks later OCT data reflected no structural changes in the cornea. Quantitative assessment of the levels of HSPD1, HSPB1, MCP-1, IL-6 and IL-8 in blood serum and vitreous did not reveal statistically significant changes after ultrasound exposure. A morphological study including an assessment of morphometric characteristics revealed the absence of apoptotic changes in the layers of the retina at different times after exposure to high-intensity ultrasound.Conclusions. We established no immediate or delayed bioeffects of high acoustic power diagnostic ultrasound exposure lasting up to 30 minutes on the biological media and ocular tissues of animals.
Elevated Troponin and Mortality in Patients with COVID-19: A Multicenter Retrospective Cohort Study
Authors: Umeh Chukwuemeka A. , Ranchithan Sobiga , Watanabe Kimberly , Tuscher Laura , Gupta Rahul 
Published: September 2022

Introduction:
Myocardial injury, causing elevated troponin levels, have been associated with worse outcomes in coronavirus disease 2019 (COVID-19) disease patients. However, our anecdotal experience did not consistently reflect this pattern. Therefore, we evaluated the outcomes of COVID-19 patients with elevated troponin.

Methods:
This is a retrospective study of 1,024 COVID-19 patients admitted to two hospitals in Southern California in the United States. We categorized the troponin levels as normal (≤1× upper reference limit (URL)), mildly elevated (>1 to ≤3× URL), and severely elevated (>3× URL). We compared the characteristics of the three troponin groups using chi-square for categorical variables and one-way Anova for the continuous variables. Finally, backward selection Cox regression analysis was carried out using mortality as a dependent variable.

Results:
Of the COVID-19 1,024 patients included in the study, 944 (92%) had normal troponin, 45 (4.4%) had mild elevation, and 35 (3.4%) had a severe elevation in troponin levels. In the multivariate Cox regression analysis, troponin elevation in patients without ST-elevation on ECG was not independently associated with mortality (hazard ratio 0.92, 95% CI 0.64-1.3). Increased risk of death was independently associated with age as well as serum C-reactive protein and serum creatinine levels.

Conclusion:
Elevated troponins without ST-elevation on ECG on hospital admission were not independently associated with increased mortality in hospitalized COVID-19 patients. However, further research is needed to fully understand the absence of a relationship between troponin elevation and mortality in our study population.
Asserting and Accompanying the Excluded Self: The Function of the Recorded Voice in Samuel Beckett’s Krapp’s Last Tape and Rockaby
Authors: Schiza Maria 
Published: September 2022

In Samuel Beckett’s plays Krapp’s Last Tape (1958) and Rockaby (1980), there is one character on stage, alone, accompanied only by the presence of his/her own recorded voice, played back to himself/herself. The recorded voice of each of the characters becomes a way of proving to themselves that they have existed before the present moment, and, at the same time, it becomes a companion, disrupting silence and aloneness. Finally, it is the recorded voice that allows the characters to fully exist while excluded from the company and comfort of others, as they fulfill their own needs through their own voice.
Glomerulonefritis rápidamente progresiva secundaria a vasculitis pauciinmune, entidad poco frecuente: caso clínico y revisión de la literatura
Authors: Giraldo Ocampo Christian Camilo , Jimenez  Bejarano Maria Fernanda , Serna Flórez Jhon 
Published: September 2022

Introducción: las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilos (ANCA) son un grupo heterogéneo de patologías, caracterizadas por la inflamación y la destrucción de vasos sanguíneos de pequeño y mediano calibre, asociados a la presencia de ANCA circulantes. Se presentan con una amplia variedad de signos y síntomas y, si no se tratan, conllevan a una alta morbimortalidad. Estos constituyen una causa poco frecuente de glomerulonefritis rápidamente progresiva y lesión renal aguda con necesidad de soporte renal, por lo que se requiere un alto índice de sospecha en el abordaje inicial.
Objetivo: con el presente artículo se busca sensibilizar al personal médico sobre la necesidad de una búsqueda activa de vasculitis como causa de glomerulonefritis y el impacto del diagnóstico y tratamiento tempranos en la condición clínica del paciente.
Presentación del caso: paciente masculino de 65 años atendido en un centro hospitalario de referencia en la ciudad de Pereira, Risaralda, quien debuta con glomerulonefritis rápidamente progresiva secundaria a poliangeítis microscópica en su posoperatorio de prostatectomía, y que progresa a lesión renal aguda con necesidad de inicio de soporte renal de tipo hemodiálisis intermitente; posterior a realizar biopsia renal y perfil de autoinmunidad, se confirma el diagnóstico de vasculitis tipo poliangeítis microscópica, se inicia manejo específico inmunosupresor, con lo que se logra la remisión de la enfermedad y con ello una mejoría en la función renal que permite suspender la terapia de reemplazo renal.
Actualmente el paciente permanece asintomático, con remisión de su enfermedad con manejo inmunosupresor, asistiendo a controles ambulatorios con Nefrología sin mención de complicaciones secundarias a terapia farmacológica.
Discusión y conclusión: En las vasculitis asociadas a los anticuerpos anticitoplasma de neutrófilos (ANCA), el diagnóstico oportuno y el establecimiento de una terapia inmunomoduladora adecuada son el pilar fundamental en el abordaje de esta entidad. Un diagnóstico tardío está directamente relacionado con un pobre pronóstico a corto plazo. El diagnóstico oportuno requiere de un índice de sospecha apropiado.
SGLT2 Inhibition, Choline Metabolites, and Cardiometabolic Diseases: A Mediation Mendelian Randomization Study
Authors: Xu Min , Zheng Jie , Hou Tianzhichao , Lin Hong , Wang Tiange , Wang Shuangyuan , Luo Jielin , Zhao Zhiyun , Li Mian , Xu Yu , Ning Guang , Bi Yufang , Wang Weiqing 
Published: September 2022

<p> </p>
<p><strong>OBJECTIVE </strong></p>
<p>To investigate the causal role of choline metabolites mediating sodium-glucose co-transporter 2 (SGLT2) inhibition on coronary artery disease (CAD) and type 2 diabetes (T2D) using Mendelian randomization (MR). </p>
<p><strong>RESEARCH DESIGN AND METHODS </strong></p>
<p>A two-sample two-step MR was used to determine: 1) causal effects of SGLT2 inhibition on CAD and T2D; 2) causal effects of three choline metabolites, total choline, phosphatidylcholine and glycine on CAD and T2D; and 3) mediation effects of these metabolites. Genetic proxies for SGLT2 inhibition were identified as variants in the <em>SLC5A2 </em>gene that were associated with both levels of gene expression and hemoglobin A1c. Summary statistics for metabolites were from UK Biobank, CAD from CARDIoGRAMplusC4D consortium, and T2D from DIAGRAM and FinnGen study. </p>
<p><strong>RESULTS</strong> </p>
<p>SGLT2 inhibition (per 1-SD, 6.75 mmol/mol [1.09%] lowering of HbA1c) was associated with lower risk of T2D and CAD (OR 0.25, 95% CI [0.12-0.54], and 0.51 [0.28-0.94], respectively), and positively with total choline (β 0.39, 95% CI [0.06-0.72]), phosphatidylcholine (β 0.40, 95% CI [0.13-0.67]) and glycine (β 0.34, 95% CI [0.05-0.63]). Total choline (OR 0.78, 95% CI [0.68-0.89]) and phosphatidylcholine (OR 0.81, 95% CI [0.72-0.91]) were associated with T2D, but not with CAD; while glycine was associated with CAD (OR 0.94, 95%CI [0.91-0.98]) but not with T2D. Mediation analysis showed evidence of indirect effect of SGLT2 inhibition on T2D through total choline (OR 0.91, 95% CI [0.83-0.99]) and phosphatidylcholine (OR 0.93, 95% CI [0.87, 0.99]) with a mediated proportion of 8% and 5% of the total effect, respectively; while through glycine (OR 0.98, [95% CI, 0.96-1.00] on CAD, with a mediated proportion of 2%. The results were well validated in at least one independent dataset.</p>
<p><strong>CONCLUSIONS </strong></p>
<p>Our study identified the causal roles of SGLT2 inhibition on choline metabolites. SGLT2 inhibition may influence T2D and CAD through different choline metabolites.</p>
Simulating and Modeling the Extensive Air Showers Development through the Estimating the Energy of some Created Particles
Authors: Fadhil Itab , Al-Rubaiee A. A.  
Published: September 2022

Using the AIRES code and three hadronic interaction models, a simulation study of the energy of created particles due to the development of an extensive air shower was carried out (EPOS-LHC, QGSJET-II-04, and Sibyll2.3c). The main focus is put on the energy of the create particles as a function of depth for (12C,56Fe, p, and 28Si) primary particles with high primary energies (1017,1018,1019, and 1020) eV with two zenith angles 0° and 30°. The New parameters were obtained by fitting the energy of created particles curves using Gaussian and linear functions for created particles, initiated by primary particles at the energy 1020 eV. Good agreement was obtained by comparing the present results with results simulated by CORSIKA simulation for primary proton at the energy 1019 eV
NÍVEL DE DISCLOSURE DE ENTIDADES DE INCORPORAÇÃO IMOBILIÁRIA
Authors: Vaz Figueira Junior Heraldo , Franzin Rodrigues Karen , Lopes da Silva Fabiana , Pelucio Grecco Marta Cristina 
Published: September 2022

Com a entrada em vigor da IFRS 15 Receita de Contrato com Cliente e diante da dissonância de entendimento sobre o momento do reconhecimento das receitas nos contratos de venda de unidades imobiliárias em empreendimentos em construção no Brasil, o objetivo desse trabalho é verificar a influência de fatores relativos ao tamanho e ao desempenho da companhia, ao nível de concentração acionária e ao nível de governança corporativa sobre a divulgação de informações dos contratos de compra e venda de unidade imobiliária não concluída, à luz da Teoria da Agência. O estudo apontou uma relação negativa entre a concentração acionária o nível de disclosure, mesmo sentido encontrado com a dummy que representa a participação de companhia no Novo Mercado. O estudo também apontou uma relação positiva com a receita líquida.
PERANAN SUHU DAN KELEMBABAN SELAMA PENYIMPANAN BENIH KEDELAI TERHADAP DAYA KECAMBAH DAN INFEKSI PATOGEN TULAR BENIH
Authors: Ramdan Evan Purnama , Kanny Putri Irene , Pribadi Edi Minaji , Budiman Budiman 
Published: September 2022

Kerusakan benih selama penyimpanan dapat disebabkan oleh infeksi patogen tular benih. Akibatnya dapat terjadi penurunan daya kecambah maupun kematian bibit. Suhu dan kelembaban merupakan salah satu faktor penyebab kemunduran fisiologi benih selama penyimpanan. Oleh karena itu, penelitian ini bertujuan untuk menguji pengaruh suhu dan kelembaban selama penyimpanan terhadap daya kecambah dan cendawan patogen yang berasosiasi dengan benih kedelai. Rancangan yang digunakan pada penelitian ini adalah Ranncangan Acak Lengkap yang terdiri dari 3 perlakuan, yaitu suhu dan kelembaban ruang (kontrol), suhu rendah, dan kelembaban rendah. Setiap perlakuan diulang sebanyak 5 kali. Benih kedelai disiapkan dengan membungkus 10 butir benih dengan kain kasa sejumlah perlakuan dan ulangan. Benih yang telah dibungkus kasa kemudian disimpan pada suhu dan kelembaban ruang, pada suhu dingin 4oC di refrigerator dan kelembaban rendah (30%) pada desikator yang ditambah silica gel. Setelah 3 minggu penyimpanan, benih kedelai ditumbuhkan dengan metode blotter test. Pada 7 hari setelah tanam, benih yang berkecambah dihitung daya kecambah dan daya infeksi cendawan patogen. Data yang diperoleh kemudian dianalisis ragam dan dilanjutkan dengan uji Tukey sebagai pada taraf5%.Hasil penelitian menunjukkan bahwa perlakuan suhu dan kelembaban dapat menjaga mutu benih dengan daya kecambah 96.67-100%. Perlakuan suhu dingin dan kelembaban rendah juga dapat menghindarkan benih kedelai dari infeksi Cladosporium sp. dan Rhizopus sp.
SARS-CoV-2 virus spreading in depending of the Earth’s magnetic field
Authors: Orlyuk M.I. , Romenets A.O. 
Published: September 2022

The paper presents the results of a study on the possible relationship between the spread of SARS-CoV-2 virus and the Earth’s magnetic field based on an analysis of digital data for 95 countries. Article is based on the statistic data of geomagnetic field and coronavirus disease parameters, which allows, in our opinion, to obtain reliable results of their interpretation, which are as follows:
The dependence of the spatial expansion of the SARS-CoV-2 virus on the value of modular values of the induction of the Earth’s main magnetic field BIGRF is established. The maximum number of diseases occurs in countries located in regions with reduced (25.0—30.0 mkT) and increased (48.0—55.0 nT) values.
The SARS-CoV-2 virus expansion of the dynamics of the geomagnetic field over the past 70 years dependence is established. Maximum diseases number refers to areas with maximum changes, in the direction of decrease (up to –6500 nT) and increase 2500 nT).
Comparison of SARS-CoV-2 disease expansion dynamics with Кр-geomagnetic field perturbation index — shows the practical absence of such connection. The ratio of the maximum daily growth of diseases to the minimums of external geomagnetic activity detected. This ratio may be due to the intensity of galactic cosmic radiation increase during this period.
The connection between the SARS-CoV-2 disease process dynamics and solar activity is shown, namely: the beginning of a pandemic is due to the superposition of minima of 11 (between 24 and 25) and 110 (120?) solar activity annual cycles. The increase of diseases number correlates well with the increase of the 25th cycle solar activity. The Spanish pandemic was characterized by a similar ratio, which arose about 110 years ago between 14—15 cycles and took place during the 15th cycle of solar activity growth phase.
The influence of partial deforestation on moisture regime: sums of precipitation and total soil moisture content for the territory of Ukraine based on data of numerical experiment LUMIP
Authors: Pysarenko L.A. , Krakovska S.V. 
Published: September 2022

The paper is dedicated to the impact of partial deforestation on sums of precipitation and part/fraction or sums of precipitation intercepted by the canopy; total soil moisture content under condition of minimal anthropogenic influence for the territory of Ukraine. In this work used data from the Land Use Model Intercomparison Project (LUMIP), which is based on Global Climate Models (GCMs). The purpose of LUMIP is to reveal patterns of changes of climate characteristics due to gradual global deforestation with a trend approximately 1 % every year and its replacement on grass or pastures for period 1850—1899. This time span is considered as the pre-industrial. The next period, 1900—1929 is without changes in forest cover. For estimation of impacts of partial deforestation the methods of anomalies over the first 20-year period (1850—1869) was used with further application of 5-year running mean of climatic characteristics to smooth their interannual variability. Coefficients of linear correlation between running mean anomalies of specific characteristic and the percentage of forest cover in grid cells with averaging over latitudinal zones, linear trends and differences were estimated.
Overally estimations have shown that the global partial deforestation doesn’t impact directly on of monthly total precipitation in the middle latitudes, particularly, in Ukraine. But gradual forest reduction decreases part or fraction of precipitation intercepted by the canopy in both cold and warm seasons with average trend up to –2,6....–1,5 %/10 years in latitudinal zones in specific grids, where forest cover was reduced. The maximal decline was up to –14.5 % in grids as the difference between the 50-year period of partial deforestation and the next 30-year period. Such an effect will causemore precipitation reaching the ground and most likely will influence surface runoff. Found, that it causes the increase in total soil moisture content with trend 0.1—4.9 %/10 years depending on month and climate model, but with most significant changes during summer and autumn seasons.
Thus, the analysis of LUMIP data for Ukraine has revealed that the partial deforestation caused the decrease of fraction part/fraction of precipitation intercepted by the canopy. Most GCMs demonstrated that this reduction provoked the increase of total soil moisture content and also can cause changes in hydrological regime and provoke higher flood frequency and other related hydrometeorological hazards in the forest part of Ukraine.
Study of the interrelation between the geneseses and reservoir properties of productive series deposits in Pirallahi field on the basis of oil-field geophysical data
Authors: Kerimova K.А. , Aliyev N.E. 
Published: September 2022

Petrophysical properties of reservoir rocks are also influenced by a certain relationship between the lithological-mineralogical composition of rocks and the reservoir properties. For this reason, the study of the relationship between the genesis of Productive Series deposits and reservoir properties provides a basis for predicting the regularity of distribution of sand particles throughout the field and making some judgments about the development of porous and permeability zones. This, in turn, is of more scientific and practical importance while identifying variation of reservoir properties of rocks in sedimentary cover.
The paper offers a rational approach that determines the relationship between the genetic origin of sedimentary rocks and their reservoir properties and expounds on the study results.
As a research area, we chose «Qirmakiustu clay», «Qirmakiustu sand», Qirmaki and Qirmakialty series of Productive Series sediments studied in sections of conventional X1, X2, X3, X4, and X5 well sections located on one profile of Pirallahifield and their sedimentation environment and facies origin have been studied in more detail.
In the section of well under the study, the average value of effective porosity (Kav.p.), average thicknesses of sandy and clayey layers (Hav.cl., Hav.sand), and the relative thickness of sand bodies (Hrel.sand) were calculated for intervals at which the facies of flow, bar, and beach plain origin were identified. The curves of these parameters’ variation across the profile were drawn.
At the same time, the curves of thicknesses of flow, bar, and beach plain origin facies were drawn for the interval identified for each well section. These curves were compared and analyzed separately for each facies.
A study of the sedimentation environment and genesis of sedimentation and a comparative analysis of lithofacial and reservoir properties may be important for accurately evaluating oil and gas presence in the study area.
Bilingualism in Indonesian Children's Language Acquisition
Authors: Apriana Aulia , Sutrisno Adi 
Published: September 2022

Language acquisition and development are two important phases in a child’s life. Hundreds of ideas have been tested to build a scientific explanation for how children may understand and produce the languages of their environment. Language intake, exposure volume and duration, and grammatical complexity all appear to have a role in influencing children's language development. These intricacies become even more complicated as children differ greatly from one another. It's on top of the several languages the children pick up along the route. Some children speak only one language (monolingual), whereas others speak multiple languages (bilingual). Apart from the endless debate about whether being bilingual is a blessing or a curse, it is fascinating to study how those children finally end up being bilinguals, either through acquisition or learning. Therefore, this article aims at portraying the phenomenon of bilingualism in Indonesian children’s language acquisition by looking at the strengths and weaknesses of being bilinguals, the important factors in second language acquisition and learning, and the strategies for second language acquisition and learning. In conclusion, to be bilingual, a child has undergone a very long process. Even though some experts are still debating whether bilingualism is beneficial or even harmful for their cognitive, psychological, and linguistic competence, children nowadays are created to be bilinguals even since they were born. As a result, those children grow up as multilingual children who are ready to cope with the dynamic of the environmental changes around them.
Gender, Language and Politics: the Representation of Theresa May on Twitter
Authors: Zakiyah Umi , Wahyudi Ribut 
Published: September 2022

The relationship between women leaders’ language, social media, and politics has been interesting to be discussed. However, there are lacks previous studies that examined the women leaders’ language and how the word choices represent women leaders on Twitter.Thus, this study aims to find out Theresa May’s language on Twitter and how those word choices represent herself as a woman leader. The data are taken from the tweets on Theresa May’s Twitter account over the last six months of her leadership reign (from January until July 2019), which focused on her crucial tweets about politics and leadership. The researchers adopted four theories to capture and analyze the data from different angles to produce the rich analysis of Theresa May’s word choices and representation on Twitter. The study revealed several word choices used by Theresa May into four categories: (1) announcement tweets, (2) attack/negative tweets, (3) personal characteristics, and (4) policy. Furthermore, the study also found that Theresa May utilized those word choices to represent herself as a political leader. She also used metaphors and pronouns to shape the desired representation. Furthermore, not all PDA elements by Fairclough Fairclough (2012) were employed due to the limited characters number on Twitter or other possible purpose(s). This study is beneficial to enrich the knowledge on how the use of language by woman leader is implicated within social and political contexts of a country. The Linguistics analysis on gender, language, and politics is another take away from this research.