bluuebunny/crossref_metadata_2025_split huggingface dataset:
Business processes monitoring based on fuzzy cognitive maps
Authors: Shevchenko Ihor , Vasyliev Denys , Prytchyn Serhii , Samoilov Andrii 
Published: October 2022

The subject matter of the article is a toolkit and monitoring processes of weakly structured business processes using fuzzy cognitive maps (FCMs). The goal is to create a model for monitoring and forecasting the course of business processes based on the FCMs, which provide flexibility and the ability to adapt to the conditions of changing circumstances in the process to be monitored, as well as insurance of the possibility of applying unstable FCM.s The task is to develop a formal monitoring system model; develop a computational FCM model; develop a method of using unstable FCMs: to develop a method for creating and using an FCM model. The methods used are graph modeling methods and computational experiment methods. The following results were obtained. A formal model of the system of monitoring and coordination of decisions regarding the course of business processes has been developed. A model of a weighted semantic graph was developed, which includes three types of vertices, namely, input vertices that will receive subjective evaluations of users regarding the course of the process, intermediate vertices that correspond to factors important from the perspective of the decision-maker, and final vertices that reflect integral evaluations of the quality of business process execution. A computational FCM model has been developed, which can adapt to the specifics of business logic due to the flexible adjustment of memory parameters and connections between FCM nodes. A method of using unstable FCMs has been developed. A methodology for creating and using FCMs designed for monitoring weakly structured business processes has been developed. Conclusions. The scientific novelty of the work is as follows: the model for monitoring and forecasting the course of business processes due to the use of a fuzzy cognitive map, in which the parameters of the importance and node memory and connections provide additional flexibility and the possibility of coordination and adaptation in the conditions of changing circumstances in the process to be monitored has been improved; a method of using unstable FCMs by setting limits on the values of the nodes excitation and using as a measure of excitation not only stable excitation values of FCM nodes but also the rate of growth of excitation values as an indicator of trends, which allows monitoring and forecasting the course of business processes has been proposed.
Liquid Smoke (Wood Vinegar) Potential as an Antiseptics Agent in Dentistry: A Systematic Review
Authors: Wibisono Gunawan , Skripsa Tira Hamdillah , Prabowo Yoghi Bagus , Boedi Rizky Merdietio 
Published: October 2022

Aseptic quality is a crucial aspect of successful dental care attainment. Various oral microbes can increase the chance of failure in dental treatment. Multiple efforts have been made to improve the aseptic quality. It is known that the antiseptics used were costly and has numerous side effects. Natural antiseptics such as liquid smoke may be a potential substitute. This research aimed to explore the potential of liquid smoke as an antiseptic in dentistry. A systematic literature search was conducted in the electronic database of PubMed/Medline, ScienceDirect, and Google Scholar using PRISMA guideline. A structured search using the Boolean string “liquid smoke AND antimicrobial AND antibacterial” was performed. Initially, 115 potential articles were discovered. After removal of duplicates and checking the availability of full-text read, eleven studies were included. Liquid smoke with 1.5-50% concentration can eliminate S. mutant, S. sanguis, S. aureus, S. epidermidis, L. acidophilus, L. salivarius, E. faecalis, P. gingivalis and C. albicans. It was also reported that it has a particular effectiveness for the disinfectant and wound healing. Liquid smoke can eliminate both oral bacterial and fungi. Further research should explore the safety aspects of utilizing liquid smoke in dental clinics.
Pengalihfungsian Asrama Mahasiswa Menjadi Fasilitas Isolasi Orang Tanpa Gejala dan Bergejala Ringan COVID-19
Authors: Darmowinoto Sandy , Astuti Puji 
Published: October 2022

<p>Pandemi COVID-19 di Indonesia telah menyebabkan penuhnya rumah sakit dan fasilitas isolasi sehingga pasien COVID-19 yang tidak bergejala atau yang bergejala ringan diminta untuk isolasi mandiri di rumah masing-masing. Padahal rumah pasien belum tentu ideal untuk isolasi, karena kurangnya jumlah kamar, ventilasi udara kurang baik dan masalah-masalah sanitasi lain. Untuk dapat segera mengatasi pandemi, orang yang terbukti terinfeksi COVID-19 harus segera diisolir dan mendapatkan penanganan medis yang baik hingga masa penyembuhan selesai untuk mengurangi potensi menjangkiti orang lain yang sehat. Oleh sebab itu, Yayasan Pendidikan Universitas Presiden memutuskan untuk mengalihfungsikan kamar-kamar asrama mahasiswa yang tidak terpakai sebagai fasilitas isolasi mandiri pasien COVID-19 yang tidak bergejala dan yang bergejala ringan. Solusi ini dapat membantu pasien COVID-19 yang tidak bergejala dan yang bergejala ringan untuk melakukan isolasi tanpa khawatir akan menularkan virus COVID-19 pada anggota keluarganya. Pengalihfungsian ini berlangsung dari 1 Februari 2021 hingga 9 Agustus 2021. Setelah itu dari 10 Agustus 2021 hingga akhir September 2021, fasilitas asrama mahasiswa juga digunakan oleh Polres Bekasi dan Pemkab Bekasi sebagai fasilitas isolasi terpusat (isoter) COVID-19. </p>
ESPAÇOS ESCOLARES: A LACUNA ENTRE A REALIDADE E AS NECESSIDADES PARA O NOVO ENSINO MÉDIO
Authors: Baruffi Pedro Paulo 
Published: October 2022

RESUMO: O artigo discute um dos temas poucos debatidos na educação, porém extremamente necessário para o processo educacional. Os espaços escolares historicamente não são valorizados na mesma proporção da importância que eles possuem. A infraestrutura escolar ficou ainda mais importante após a lei da Reforma do Ensino Médio que dentre as tantas mudanças aumenta a carga horária nas escolas. Os alunos passam mais tempo na escola com as mesmas condições de sempre dificultando resultados diferentes. O estudo apresenta a infraestrutura das escolas estaduais de uma região específica do estado de Santa Catarina e analisa um caderno emitido pelo estado com roteiros pedagógicos dos componentes curriculares eletivos que aponta os espaços necessários para a aplicação dessas atividades. A infraestrutura da maioria das escolas da região é adequada de acordo com uma escala utilizada, porém ao analisar os espaços solicitados para os componentes eletivos, há uma verdadeira lacuna. Isso tudo reforça a ineficácia da reforma do Ensino Médio, pois não dialoga com a realidade das escolas.

Palavras-chave: Espaço. Infraestrutura. Reforma do Ensino Médio.

ABSTRACT: The article discusses one of the few topics discussed in education, but extremely necessary for the educational process. Historically, school spaces are not valued in the same proportion of the importance they have. School infrastructure has become even more important after the High School Reform law, which among many changes increases the workload in schools. Students spend more time at school with the same infrastructure as always, making different results difficult.
The study presents the infrastructure of state schools in a specific region of the state of Santa Catarina and analyzes a notebook issued by the state with pedagogical scripts of the elective curricular components that points out the necessary spaces for the application of these activities. The infrastructure of most schools in the region is adequate according to the scale used, but when analyzing the infrastructure requested for the elective components, there is a real gap. All of this reinforces the ineffectiveness of the reform of high school, as it does not dialogue with the reality of schools.

Keywords: Space. Infrastructure. High School Reform.
Antarmuka Sebagai Media Komunikasi Dengan Sistem
Authors: - Karpen 
Published: October 2022

Antarmuka atau disebut juga denganÂ Interface adalah kegiatan yang sering dilakukan oleh manusia pada saat menggunakan alat bantu untuk meringankan pekerjaannya. Kata ini mungkin masih asing kedengarannya. ditelinga kita, antarmuka dapat menerima komunikasi atau informasi dari penggunaÂ (user) dan sebaliknya dapat memberikan komunikasi atau informasi balik kepada pengguna yang disebut dengan User interface. Pada antarmuka menampilkan penjelasan sebagai media komunikasi dari sistem dan memberikan panduan pemakaian sistem secara menyeluruh tahap demi tahap sehingga user mengerti apa yang akan dilakukan terhadap sistem. Hal yang terpenting dalam membangun suatu antarmuka pengguna (user interface) adalah kemudahan dalam mengkomunikasikan dan memakai serta untuk menjalankanÂ sistem secara interaktif. Antarmuka sebagai media komunikasi harus dapatÂ memberikan layanan kepada pengguna (user) secara efisien dan efektif
Analisa Aplikasi Power Generation Transmition Geographic Information System (PGT GIS) Terhadap Kinerja di Chevron Pacific Indonesia
Authors: - Mirhot Stewart Sihombing , - Tashid 
Published: October 2022

Aplikasi Power Generation Transmition Geographic Information System (PGT GIS) adalah aplikasi yang dibuat oleh departemen PGT untuk membantu pekerjaan maintenence yakni dengan cara menemukan koordinat lokasi kerja, keberadaan pole (tiang listrik), memonitor pertumbuhan pohon tinggi di bawah powerline. Namun kenyataannya terdapat ketidakakuratan data yang ditampilkan pada aplikasi ini yang menyebabkan kinerja menjadi terganggu. Oleh karena itu perlu dilakukan analisa terhadap sistem aplikasi GIS dan menganalisa seberapa besar pengaruh terhadap maintenence di PGT menggunakan metode PIECES yaitu: Performance, Informations and data, Economics, Control and security, Efficiency, danÂ Service. Hasil dari penelitianÂ ini nantinya akan menunjukkan bahwa terdapat beberapa keunggulan atau kekuatan sistem yang dapat menunjang proses maintenence di perusahaan. Tetapi hasil penelitian iniÂ juga memperlihatkan kekurangan dan kelemahan sistem, sehingga sistem yang ada ini perlu adanya perbaikan ataupun penyempurnaan menuju ke arah yang lebih baik lagi
Assessment of labially impacted canines traction mode with clear aligners vs. fixed appliance: A comparative study based on 3D finite element analysis
Authors: Xia Qian , He Yao , Jia Lurong , Wang Chunjuan , Wang Weixu , Wang Chao , Song Jinlin , Fan Yubo 
Published: October 2022

Purpose: The objective of this study was to evaluate and compare the biomechanical differences between clear aligner and fixed appliance in the traction of labially impacted canines based on 3D finite element analysis.Methods: A series of patient-oriented finite element models were constructed, including a maxillary dentition with a right labially canine, maxilla, periodontal ligaments, traction attachments, and clear aligners. The two most common clinical scenarios were investigated: Scenario A: impacted canine (distal) and Scenario B: impacted canine (mesial). For each clinical scenario, three traction models with clear aligners and one fixed appliance model were established.Results: In all four models, the impacted canines exhibited similar initial displacement tendencies of mesially rotated in Scenario A and distally rotated in Scenario B, and with small differences in periodontal ligament stress magnitude. However, the sum of the periodontal ligament stresses of the anchorage teeth in the clear aligner mode was in the range of 56.28–76.21 kPa and in the fixed appliance mode was in the range of 6.61–7.22 kPa. The maximum value of initial displacement of the anchorage teeth in the clear aligner mode was in the range of 13.71–19.72 μm, while in the fixed appliance mode was 3.10–3.92 μm.Conclusion: For impacted canines, clear aligner mode and fixed appliance mode have little difference in biomechanical effect. However, the anchorage teeth in the clear aligner mode endure higher stress and show a more pronounced displacement tendency. In addition, the biomechanical effects of different clear aligner traction models are various but not obvious.
Factor VIII companion diagnostic for haemophilia
Authors: Hu Chunxiao , Annese Valerio F. , Giagkoulovits Christos , Barrett Michael P. , Cumming David R. S. 
Published: October 2022

Haemophilia is predominantly an inherited disorder that impairs the body’s ability to make blood clots, a process needed to stop bleeding. The condition of this disease is complex to manage, but many patients do so through home therapy and often only see their core multidisciplinary healthcare team annually. There is an increasing need for patients to be able to monitor their condition efficiently at home while staying connected with their healthcare team. As a consequence, a low-cost handheld self-monitoring solution for clotting factor is required. Here we have demonstrated a suitable one-step Factor VIII companion diagnostic sensing approach based on a chromogenic assay for haemophilia A. The results show comparable performance to the gold standard method. Our approach is able to deliver accurate cost-effective results in under 5 min from undiluted human plasma. It has the potential to be able to reduce the human and monetary costs of over- or under-medication for haemophiliacs.
Bone regeneration materials and their application over 20 years: A bibliometric study and systematic review
Authors: Zhang Xudong , Li Qianming , Wang Zhengxi , Zhou Wei , Zhang Linlin , Liu Yingsheng , Xu Ze , Li Zheng , Zhu Chen , Zhang Xianzuo 
Published: October 2022

Bone regeneration materials (BRMs) bring us new sights into the clinical management bone defects. With advances in BRMs technologies, new strategies are emerging to promote bone regeneration. The aim of this study was to comprehensively assess the existing research and recent progress on BRMs, thus providing useful insights into contemporary research, as well as to explore potential future directions within the scope of bone regeneration therapy. A comprehensive literature review using formal data mining procedures was performed to explore the global trends of selected areas of research for the past 20 years. The study applied bibliometric methods and knowledge visualization techniques to identify and investigate publications based on the publication year (between 2002 and 2021), document type, language, country, institution, author, journal, keywords, and citation number. The most productive countries were China, United States, and Italy. The most prolific journal in the BRM field was Acta Biomaterialia, closely followed by Biomaterials. Moreover, recent investigations have been focused on extracellular matrices (ECMs) (370 publications), hydrogel materials (286 publications), and drug delivery systems (220 publications). Research hotspots related to BRMs and extracellular matrices from 2002 to 2011 were growth factor, bone morphogenetic protein (BMP)-2, and mesenchymal stem cell (MSC), whereas after 2012 were composite scaffolds. Between 2002 and 2011, studies related to BRMs and hydrogels were focused on BMP-2, in vivo, and in vitro investigations, whereas it turned to the exploration of MSCs, mechanical properties, and osteogenic differentiation after 2012. Research hotspots related to BRM and drug delivery were fibroblast growth factor, mesoporous materials, and controlled release during 2002–2011, and electrospinning, antibacterial activity, and in vitro bioactivity after 2012. Overall, composite scaffolds, 3D printing technology, and antibacterial activity were found to have an important intersection within BRM investigations, representing relevant research fields for the future. Taken together, this extensive analysis highlights the existing literature and findings that advance scientific insights into bone tissue engineering and its subsequent applications.
Quercetin protects porcine oocytes from in vitro aging by reducing oxidative stress and maintaining the mitochondrial functions
Authors: Jiao Yafei , Wang Yixian , Jiang Tiantuan , Wen Keying , Cong Peiqing , Chen Yaosheng , He Zuyong 
Published: October 2022

Quercetin (QUE) is a component of the flavonoid family that shows various therapeutic properties, such as antioxidant effects. However, whether QUE affects porcine oocyte in vitro aging has not yet been investigated. Therefore, in this study, we applied various doses of QUE to freshly isolated porcine oocytes and found that 10 µM QUE improved the oocyte maturation rate in vitro, as reflected by the increased degree of cumulus cell expansion and first polar body extrusion. More importantly, we found that QUE reduced in vitro aging and improved the maturity level of porcine oocytes after another 24 h of culturing, accompanied by the upregulated expression levels of bone morphogenetic protein 15, growth differentiation factor 9, Moloney sarcoma oncogene, and cyclin-dependent kinase 2. In addition, we found that QUE treatment significantly reduced the intracellular reactive oxygen species levels, apoptosis, and autophagy and upregulated the expression levels of superoxide dismutase 2 and catalase in aged porcine oocytes. In addition, QUE restored impaired mitochondrial membrane potential and spindle assembly in aged porcine oocytes. Our findings demonstrate that QUE can protect porcine oocytes from in vitro aging by reducing oxidative stress and maintaining mitochondrial function.
Predictors and neurological consequences of periprocedural cerebrovascular events following transcatheter aortic valve implantation with self-expanding valves
Authors: Suhai Ferenc Imre , Varga Andrea , Szilveszter Bálint , Nagy-Vecsey Milán , Apor Astrid , Nagy Anikó Ilona , Kolossváry Márton , Karády Júlia , Bartykowszki Andrea , Molnár Levente , Jermendy Ádám L. , Panajotu Alexisz , Maurovich-Horvat Pál , Merkely Béla 
Published: October 2022

AimsTo evaluate the patient- and procedure-related predictors of transcatheter aortic-valve implantation (TAVI)-associated ischemic brain lesions and to assess the effect of silent cerebral ischemic lesions (SCIL) on neurocognitive function.Methods and resultsWe investigated 113 consecutive patients with severe aortic stenosis who underwent brain magnetic resonance imaging (MRI) within a week following TAVI. To assess periprocedural cerebral ischemic lesions, diffusion-weighted MRI was utilized. We used multivariate linear regression to identify the independent predictors of TAVI-related ischemic lesion volume (ILV) and periprocedural stroke. Neurocognitive evaluation was performed before and following TAVI at 6-month and one-year follow-up. Following TAVI, a total of 944 new cerebral ischemic lesions were detected in 104 patients (92%). The median ILV was 257 μl (interquartile range [IQR]:97.1–718.8μl) with a median lesion number of 6/patient [IQR:2–10]. The majority of ischemic lesions were clinically silent (95%), while 5% of the lesions induced a stroke, which was confirmed by MRI. Predilatation (β = 1.13[95%CI:0.32–1.93], p = 0.01) and the number of valve positioning attempts during implantation (β = 0.28[95%CI:0.06–0.50], p = 0.02) increased the log-transformed total ILV. Predilatation (OR = 12.04[95%CI:1.46–99.07], p = 0.02) and alternative access routes (OR = 7.84[95%CI:1.01–61.07], p = 0.02) were associated with stroke after adjustments for comorbidities and periprocedural factors. The presence of SCILs were not associated with a change in neurocognitive function that remained stable during the one-year follow-up.ConclusionWhile periprocedural ischemic lesions are frequent, most of them are clinically silent and might not impact the patients' neurocognitive function. The number of valve positioning attempts, predilatation, and alternative access routes should be taken into consideration during TAVI to reduce the ILV and risk for stroke.
Sigmoid isostiffness-lines: An in-vitro model for the assessment of aortic stenosis severity
Authors: Buffle Eric , Stucki Michael , Zheng Shaokai , Chiarelli Maxime , Seiler Christian , Obrist Dominik , de Marchi Stefano F. 
Published: October 2022

IntroductionThe aortic valve opening area (AVA), used to quantify aortic stenosis severity, depends on the transvalvular flow rate (Q). The currently accepted clinical echocardiographic method assumes a linear relation between AVA and Q. We studied whether a sigmoid model better describes this relation and determined “isostiffness-lines” across a wide flow spectrum, thus allowing building a nomogram for the non-invasive estimation of valve stiffness.MethodsBoth AVA and instantaneous Q (Qinst) were measured at 10 different mean cardiac outputs of porcine aortic valves mounted in a pulsatile flow loop. The valves' cusps were chemically stiffened to obtain three stiffness grades and the procedure was repeated for each grade. The relative stiffness was defined as the ratio between LV work at grade with the added stiffness and at native stiffness grade. AVApeak¯ corresponding to the selected Qpeak¯ of the highest 3 and 5 cardiac output values was predicted in K-fold cross-validation using sequentially a linear and a sigmoid model. The accuracy of each model was assessed with the Akaike information criterion (AIC).ResultsThe sigmoid model predicted more accurately AVApeak¯ (AIC for prediction of AVA with Qpeak¯ of the 3 highest cardiac output values: –1,743 vs. –1,048; 5 highest cardiac output values: –1,471 vs. –878) than the linear model.ConclusionThis study suggests that the relation between AVA and Q can be better described by a sigmoid than a linear model. This construction of “isostiffness-lines” may be a useful method for the assessment of aortic stenosis in clinical echocardiography.
Efficacy of computed tomography in diagnosing pulmonary hypertension: A systematic review and meta-analysis
Authors: Chen Riken , Liao Huizhao , Deng Zhenan , He Zhenfeng , Zheng Zhenzhen , Lu Jianmin , Jiang Mei , Wu Xiaofeng , Guo Wenliang , Huang Zijie , Chen Huimin , Hong Cheng , Zhong Nanshan 
Published: October 2022

ObjectiveThis study seeks to evaluate the diagnostic value of computed tomography (CT) in pulmonary hypertension.MethodPubMed, Embase, Scopus, and Web of Science databases were searched to obtain the relevant English literature, and the retrieval time until June 2022. The quality of the included studies is evaluated using the QUADAS-2 tool. The quality of the included studies was assessed, followed by a meta-analysis, analyze heterogeneity, summarize sensitivity and specificity, draw the comprehensive subject working characteristics (sROC) curve, calculate the area under the curve and conduct subgroup analysis and sensitivity analysis to find the source of the heterogeneity.ResultsA total of 12 articles were included, all with pulmonary artery diameter/liter aortic diameter &gt;1 or 1 as the diagnostic criteria for pulmonary hypertension, and a total of 1,959 patients were included. Deek’s funnel plot analysis suggests that there is no significant publication bias (P = 0.102). The combined sensitivity was 0.652 (95% CI: 0.579, 0.719), combined specificity was 0.830 (95% CI: 0.796, 0.880), positive likelihood ratio was 3.837 (95% CI: 3.215, 4.579), negative likelihood ratio was 0.419 (95% CI: 0.346, 0.507), diagnostic odds ratio was 9.157 (95% CI: 6.748, 12.427) and area under the summary receiver operating characteristic (SROC) curve was 0.84 (95% CI: 0.81, 0.87).ConclusionThe CT examination of pulmonary artery diameter/aortic artery hypertension is worthy of clinical application.