bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends among patients with endometriosis over a 7-year period and the impact of the COVID-19 pandemic. Experience from an academic high level endometriosis centre in Germany.
Authors: Keilmann Lucia , Beyer Susanne , Meister Sarah , Jegen Magdalena , Buschmann Christina , Schröder Lennard , Keckstein Simon , Jeschke Udo , Burges Alexander , Mahner Sven , Trillsch Fabian , Kost Bernd , Kolben Thomas 
Published: July 2022

Abstract
PurposeEndometriosis is known to be an underestimated disease. Lately the awareness of the disease seems to have improved. Aim of this analysis is to provide an overview of the development of treatment of patients diagnosed with endometriosis. This includes a special scope on implications of the COVID-19 pandemic since in multiple settings postponed treatments resulting in negative impact on prognosis were reported. Material and MethodsWe analysed the development of numbers of patients treated for endometriosis in an academic centre within a 7 year-period, 01/2015-12/2021, performing a systematic analysis of ICD-10-Codes from our computer system used in clinical routine.Results Treatment numbers increased over the past 7 years, i.e. 239 treated cases in 2015 vs. 679 in 2021.Following restrictions for outpatient evaluation and surgical capacity at our centre during COVID-19 pandemic the numbers of treated patients were reduced, especially in the first lockdown period. The comparison of 2020 to 2019 showed a reduction in April 2020 of -37 % in outpatient department and up to -90% for surgically treated patients. Comparing to 2019, we found a reduction of surgical interventions in 2020 by -9 % and an increase by 83% in 2021.ConclusionRaising numbers of patients treated for endometriosis point to a new awareness for the disease. After the decline during the lockdown period numbers raised again, leading to a delay, but not an omission of treatment. A certified endometriosis centre with established and well-organized structures is required to improve not only treatment results but also quality of life of those affected.
Continuous-time Quantum Walk based on Cycle under Broken-line Decoherent Noise
Authors: Shi Wei-Min , Tian Pan , Zhou Yi-Hua , Yang Yu-Guang 
Published: July 2022

Abstract

At present, decoherence continuous-time quantum walks are only based on measurement decoherence, but a new broken-line noise model for continuous-time quantum walks on the cycle is proposed. In this scheme, we first construct the Hamiltonian H according to four cases including no broken links, the link to the left of the node is broken, the link to the right of the node is broken, and both links are broken, and then the probability of a walker is reconstructed. The analysis shows that with the increase of the probability of disconnection, the oscillation of the walk gradually weakens and becomes a peak distribution, and with the continuous increase of the walk time, the probability distribution of each vertex tends to be uniform. In addition, we also analyze the mixing time of this walk model and find that a small amount of broken chain decoherence can help reduce the mixing time, thereby improving the performance of quantum walks.
BIRB796 reduces p38MAPK and pHsp27 proteins in U87MG Glioma cells
Authors: Biltekin Sevde Nur , Uçar Evren Önay 
Published: July 2022

Abstract
Background: Hsp27 phosphorylation in glioma cells is closely related to tumor cell proliferation and apoptosis inhibition. The main purpose of this study is to inhibit the phosphorylation of Hsp27 by MAPK inhibitor, BIRB796. Thereby reducing the amount of pHsp27 that inhibits the mechanism of apoptosis in cancer cells.Methods and Results: The effect of bortezomib and BIRB796 on the U87MG cells was examined. Hsp27 and pHsp27 proteins expression level were exhibited by Western Blot analysis. Besides, we examined BIRB796 effects on p38MAPK (a, b) enzyme inhibition and caspase 3 activity. According to MTT analysis, bortezomib decreased cell proliferation dose dependent manner and BIRB796 did not cause significant reduction. For further analysis, 5nM bortezomib, and 100, 250, 500 nM BIRB796 concentrations that show neither a cytotoxic nor a proliferative effect on the cells were used as combined treatment. It was seen that 5 nM bortezomib treatment significantly induced pHsp27 (76%) and Hsp27 (48%) expression levels in the glioma cells. It was found that BIRB796 treatments significantly decreased the level of Hsp27 and pHsp27. The combined treatments significantly reduced pHsp27 expression level. Our results showed that all the treatments also significantly increased caspase 3 activation. Moreover BIRB796 inhibited p38a and p38b activities depending on time and this agent effect on p38a was stronger than p38b.Conclusion: These results demonstrate that the cellular MAPK inhibitor BIRB796 agent may be an effective therapeutic option in cancer cells by reducing resistance and decreasing pHsp27 expression in the treatment of brain cancer.
The strategies of faculty development based on their role and learning styles in the Iranian University of Medical Sciences
Authors: Bazrafkan Leila , Ghasemi Sima , Rakhshani Tayebeh , Shokrpour Nasrin 
Published: July 2022

Abstract
In this study, we aimed to explain the strategies of faculty development based on their role and learning styles at Shiraz University of Medical Sciences. We conducted a qualitative content analysis study in 2021 by purposive, snowball sampling, with a maximum variation of age and experience levels of faculty members. Eighteen participants were enrolled in this study, and data collection consisted of two phases of semi-structured interviews and brainstorming group technique. Data were categorized into two themes and six related subthemes, based on their similarities and differences after frequent summarization. The second theme was the best strategies in empowering the teacher with four sub-themes, including problem-based learning, integration of methods, evaluation-based education, and scholarship in education (PIES), which explains the strategies that can support the development of teachers in medical sciences. PIES could explain the practical strategies that can support the development of teachers in medical sciences.
Dichorionic Diamniotic Twin Pairs with Complex Congenital Heart Disease
Authors: Kohli Utkarsh , Perrotta Melissa , Aljemmali Saif , Sosnowski Cyndi , Cardenas Yvonne , Sharma Kavita 
Published: July 2022

Abstract
Complex congenital heart disease (CHD) in each of dichorionic diamniotic (DiDi) twin pairs is extremely rare and has not been well characterized. Four DiDi twin pairs were included in this multi-institutional case series. The congenital cardiac abnormalities noted included tetralogy of Fallot (ToF) with pulmonary atresia and collaterals (n = 1), ToF with absent pulmonary valve (n = 1), ToF (n = 2), discontinuous right pulmonary artery (RPA) (n = 1), tricuspid atresia (TA) with normally related great arteries and pulmonary valve stenosis or atresia (n = 2) and coarctation of aorta (CoA) with bicuspid aortic valve (BAV) and borderline left-sided structures (n = 1). Genetic testing was obtained on seven of the eight twins but did not reveal any causal abnormality. A comprehensive review of literature yielded another 8 DiDi twin pairs with complex CHD. The CHD noted in these twin pairs included ToF (n = 2), CoA (n = 4), corrected transposition of great arteries (ccTGA) (n = 2), truncus arteriosus (n = 2), complete common atrioventricular canal (CCAVC) (n = 2), hypoplastic left heart syndrome (HLHS) (n = 2), Shone’s complex (n = 1) and hypoplastic right heart syndrome (HRHS) (n = 1). Limited genetic testing was obtained on 4 of these twins and revealed trisomy 21 in a twin pair. Conotruncal abnormalities (42%), CoA (21%), and abnormalities of the right ventricle, the right ventricular outflow tract and pulmonary arteries (17%) are more prevalent in DiDi twins with complex CHD. Clustering of these abnormalities suggests a possible genetic basis; however, genetic testing was obtained on eleven of the twins, and except for trisomy 21 in a twin pair both of whom had CCAVC, did not reveal any causal abnormality. A major direct genetic contribution is therefore unlikely and like other CHD, the underlying etiopathological basis is likely multifactorial.
Probing the atomically diffuse interfaces in core-shell nanoparticles in three dimensions
Authors: Li Zezhou , Xie Zhiheng , Zhang Yao , Mu Xilong , Yin Hai-jing , Zhang Ya-Wen , Ophus Colin , Zhou Jihan 
Published: July 2022

Abstract
Deciphering the three-dimensional atomic structure of solid-solid interfaces in core-shell nanomaterials is the key to understand their remarkable catalytical, optical and electronic properties. Here, we probe the three-dimensional atomic structures of palladium-platinum core-shell nanoparticles at the single-atom level using atomic resolution electron tomography. We successfully quantify the rich structural variety of core-shell nanoparticles including bond length, coordination number, local bond orientation order, grain boundary, and five-fold symmetry, all in 3D at atomic resolution. Instead of forming an atomically-sharp boundary, the core-shell interface is atomically diffuse with an average thickness of 4.2 Å, irrespective of the particle’s size, morphology, or crystallographic texture. The high concentration of Pd in the interface is highly related to the electric double layers of the Pd seeds. These results advance our understanding of core-shell structures at the fundamental level, providing potential strategies into nanomaterial manipulation and chemical property regulation.
Metadichol® is a nano lipid emulsion that expresses all 48 nuclear receptors in stem and somatic cells
Authors: Raghavan Palayakotai R 
Published: July 2022

Abstract

Human nuclear receptors (NRs) involve 49 ligand-dependent transcription factors that are important for regulating the cell cycle and processes. There are many literature references to work on NR expression in many organs, abnormal cells, and tissues. However, a simple universal method to study the expression of NR is still missing. Here, we present systematic profiling of NRs in human umbilical cord stem cell lines and assess the expression of the 48 human NRs by quantitative real-time (qRT)-PCR using Metadichol, a nanoemulsion made of natural lipid alcohol. Metadichol-treated umbilical cord cells and fibroblasts, where all cells expressed NRs at a concentration range of 1 pg-100 ng/mL in a dependent manner, were detected by qRT-PCR and qualified by Western blotting. This method will allow the study of many organs and tissues and expand our understanding of the role of NRs and their role in mitigating diseases.
Suspension of structures in two-dimensional topologies with or without the presence of 𝒈 ≥ 1 genus deformations for canonical 2²η stabilizer points
Authors: Bhattacharjee Deep 
Published: July 2022

Abstract
Parameterizing the diagonal points for each orbit +∓ and other —= over 𝒅𝒆𝒈₂ topologies considering the minimum genus 1 with marked points 2² over stabilizer moduli η when composed under loads or vibrations positive-∂ - negative-∂̅ - null-neutral-∂̅∂̅̅̅ from neutral-∂∂̅ phase alters the state ω to ω⋆ induces a change in genus geometries from rings at the mouth being hyperbolic σ× inside to hyperbolic or elliptic or Euclidean σ outside transits the function acting on the topology ⋆∶ω⟶ω⋆ suspends the surface by deforming stabilizer moduli η except in case of null-neutral-∂̅∂̅̅̅ ̅ iff class [ζ] is satisfied. Higher 𝒅𝒆𝒈 generalizations are not taken for this paper.
Visualizing electroluminescence process in light-emitting electrochemical cells.
Authors: Yasuji Kosuke , Sakanoue Tomo , Yonekawa Fumihiro , Kanemoto Katsuichi 
Published: July 2022

Abstract
Electroluminescence (EL) generally occurs via the fundamental recombination reaction of electron and hole, but the dynamics measurement of the reaction process has not been achieved so far. Here, we explore the operation dynamics of organic EL-devices in ionic liquid (IL)-based light-emitting electrochemical cells (LECs), by means of multi-timescale spectroscopic measurements synchronized with the LEC operation. Bias-induced absorption measurements under steady state conditions reveal that the migration of IL-electrolyte ions proceeds on a time scale of tens of seconds. The bias-modulation (BM) spectroscopic measurements for injected holes allow us to observe the behavior of p-doped layers varying with the bias-magnitude from growth to saturation and to recession. Simultaneous BM measurements with the EL intensity and current in a wide bias range show that, in the bias of the highest EL conversion efficiency, holes are not used for the doped layer formation but are efficiently consumed in the recombination process. The dynamics of LEC operation is directly visualized by time-resolved BM spectra, which leads to the following findings. Electron injection occurs more slowly than hole injection, causing delay of EL with respect to the p-doping. The EL of LEC starts with an insufficiently grown n-doped layer under a sufficient p-doped layer formation. N-doping then progresses gradually with the recession of the p-doped layer while the EL intensity remains constant. With the growth of n-doped layer, hole injection is suppressed gradually due to charge balance, leading to the accumulation of hole on the anode, and through them, the LEC operation reaches equilibrium. These spectroscopic techniques allow for studying the operation dynamics of LEC and can be an effective evaluation tool applicable widely to organic EL-devices.
Dysimilarities In The Gut Metabolome Of Rabbits With Genetic Differences In Their Resilient Potential
Authors: Casto-Rebollo Cristina , Argente María José , García María Luz , Blasco Agustín , Ibáñez-Escriche Noelia 
Published: July 2022

Abstract
Background
The gut-derived metabolites are key actors in the host-microbiota crosstalk and can have either beneficial or detrimental effects on the host. Gut metabolome could be a potential strategy to enrich the knowledge of host-gut interactions, providing another way of improving key traits such as animal resilience and welfare in livestock systems. Animal resilience has now become a critical livestock trait because of the high demand for more sustainable productions. Environmental variance (VE), the within-individual variance of traits due to environmental factors, is used as a key measure to improve resilience. Studying the gut microbiome composition can reveal the mechanisms behind animal resilience due to its influence on host immunity. The aim of this study was to identify the gut-derived metabolites underlying the VE of litter size (LS), for which we performed an untargeted gut metabolome analysis in two rabbit populations divergently selected for low (n = 14) and high (n = 14) VE of LS. Partial least square-discriminant analysis and Bayesian statistics were computed to determine dissimilarities in the gut metabolites of the rabbit populations.
Results
We identified 15 metabolites that can discriminate between rabbit populations with a prediction performance of 99.18% for resilient and 90.42% for non-resilient populations. The most reliable metabolites identified were glycerophosphoglycerol, equol, behenoylcarnitine, arachidoylcarnitine, ethyl beta-glucopyranoside, 3-(4-hydroxyphenyl)lactate, N6-acetyllysine, 5-aminovalerate and succinylcarnitine. A great abundance of acylcarnitines and metabolites from the phenylalanine, tyrosine, and tryptophan metabolism were found in the non-resilient population. Acylcarnitines and metabolites from AAAs (like kynurenine and anthranilate) can impact the inflammatory response and the health status of animals.
Conclusions
This is the first study to identify gut metabolites that can act as the VE of LS biomarkers as well as resilience biomarkers. The smaller number of acylcarnitines and metabolites derived from the phenylalanine, tyrosine and tryptophan metabolism suggested that resilient animals were better able to cope with stressful events. However, further studies will be needed to determine the causal role of these metabolites in health and disease.
A photometric study of regolith intimate mixing with ice-like impurity
Authors: Deb Dwaipayan , Chakraborty Pavan 
Published: July 2022

Abstract
Surfaces of solid solar system objects are covered by layers of particulate materials called regolith originated from their surface bedrock. They preserve important information about surface geological processes. Often regolith is composed of more than one type of particle in terms of composition, maturity, size, etc. Experiments and theoretical works are being carried out to constrain the result of mixing and extract the abundance of compositional end-members from regolith spectra. In this work we have studied, photometric light scattering from simulated surfaces made of two different materials – one is highly bright quartz particles (average diameter 78.336 µm) and the other moderately bright sandstone particles (average diameter 253.757 µm). The samples were mixed with varying proportions and investigated at normal illumination conditions to avoid the shadowing effect. Said combinations may resemble ice mixed regolith on various solar system objects and therefore it is important for in situ observations. We find that the combinations show a linear trend in the corresponding reflectance data in terms of their mixing proportion and some interesting facts come out when compared to previous studies.
Secrecy Outage of an Energy Harvesting Multi-Relay Network with Multiple-Antenna
Authors: Sharma Shashibhushan , Roy Sanjay Dhar , Kundu Sumit 
Published: July 2022

Abstract
Secrecy performance of a cooperative communication network is analyzed in which source transmits information to a destination via multiple relays, assisted with multiple antennas, where an eavesdropper is able to eavesdrop the information signal from relay only. The direct link does not exist between source and destination due to deep fading and shadowing effect and transmission of a signal from source to destination is completed in two phases; first is the broadcasting phase and other is the relaying phase. Each relay follows decode and forward protocol and receives the information signal with multiple antennas. A selected relay harvests energy from received multiple signals through multiple antennas. Both information and jamming signals are transmitted by the selected antenna of a selected relay. It has been seen that a selected relay harvests energy 0.3706 joule with an array of 5 antennas when the source transmits the information signal with 5 dBW power. We have also observed that the performance increased by 99.24% in case of an array four antennas system with respect to an array of two antennas system when secrecy threshold is 1 bit/s/Hz . Secrecy performance is measured in terms of secrecy outage probability (SOP). A closed-form expression of the SOP is derived to analyze the secrecy performance which is verified by the simulation results.
Laboratory evaluation of the efficacy of bucket chlorination guidelines at inactivating Vibrio cholerae for waters of varying quality
Authors: String Gabrielle M. , Huang Annie , Lantagne Daniele 
Published: July 2022

Abstract
Bucket chlorination, where chlorine is dosed directly into water collection containers, is a point-of-source water treatment intervention commonly implemented in cholera outbreaks. There is little previous data on chlorine efficacy against Vibrio cholerae in different waters and appropriate dosage regimes. We evaluated V. cholerae reduction and free chlorine residual (FCR) in waters with four turbidities (1/5/10/50 NTU), two total organic carbon (TOC) concentrations (0.4, 1 mg/L), and two dosing schemes (fixed-dose of 2 or 4 mg/L, variable-dose based on jar testing) treated with three chlorine types (HTH, NaOCl, NaDCC). We found that chlorine was efficacious at reducing V. cholerae by ≥2.75 to ≥3.63 log reduction value (LRV); variably dosed reactors were dosed higher, met ≥0.5 mg/L FCR at 30 min, and had higher LRVs (p=0.024) than fixed doses; and low TOC reactors had more samples ≥0.2 mg/L FRC at 4 h (p=0.007). Our results are conservative, as internationally recommended additives to create test water increased chlorine demand, highlighting the challenge of replicating field conditions in laboratory testing. Overall, we found that chlorine can efficaciously reduce V. cholerae; we recommend further research on appropriate chlorine demand for test waters; and we recommend establishing appropriate chlorine doses based on source water and taste/odor acceptability in bucket chlorination programs.
Estimating the permeability coefficient of soil using CART and GMDH approaches
Authors: Torabi Mina , Sarkardeh Hamed , Mirhosseini S. Mohammad 
Published: July 2022

Abstract
Permeability coefficient of soil (k) is one of the most important parameters in groundwater studies. This study, two robust explicit data-driven methods, Including classification and regression trees (CART) and the group method of data handling (GMDH) were developed using the characteristics of soil, i.e., clay content (CC), water content (ω), liquid limit (LL), plastic limit (PL), specific density (γ), void ratio (e) to generate predictive equations for prediction of k. When compared to CART; mean absolute error (MAE) = 0.0051, root mean square error (RMSE) = 0.0088, scatter index (SI) = 64.00%, correlation coefficient (R) = 0.7841, index of agreement (IA) = 0.8830; the GMDH equation produced the lowest error values; MAE = 0.0044, RMSE = 0.0072, SI = 52.17%, R = 0.8493, Ia = 0.9184; in testing stage. Although, GMDH had better performance, however, CART and GMDH could be considered effective approaches for the prediction of k.
A comparative study on equilibrium scour volume around circular cylinders in clay–sand mixed cohesive beds, at near threshold velocity of sand – an experimental approach
Authors: Chaudhuri Susanta , Pandey Manish , Debnath Koustuv , Oliveto Giuseppe 
Published: July 2022

Abstract
Local scour around a bridge pier is a complex phenomenon resulting from the interaction of the three-dimensional turbulent flow field around hydraulic structures. An accurate estimation of scour depth below the stream-bed is important during design since it determines the foundation levels and the expansion of the bridge foundation structures. The present study reveals the results of flume experiments on equilibrium scour depth and scour volumes around circular bridge pier models in clay–sand sediment mixtures. The scouring process in a cohesive sediment mixture is a complex interaction between clay–sand network structure and bed shear stresses. The bed shear stress reduces inside the scour hole as scour depth increases, and this is related to the different modes of scouring in clay–sand mixtures. An exponential equation for the non-dimensional scour volume is proposed considering all the experimental runs to get a specific understanding of the surrounding volume of scour hole from maximum equilibrium scour depth in a clay–sand mixed cohesive bed, when the approach flow velocity is near to the critical velocity for mixed sand. The proposed equations are validated using the pre-existing data from the literature dealing with experimental investigations on bridge scour using clay–sand mixed cohesive sediment and show good agreement with observed data.