bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benefits of tailored hepatocellular carcinoma screening in patients with cirrhosis on cancer‐specific and overall mortality: A modeling approach
Authors: Ningarhari Massih , Mourad Abbas , Delacôte Claire , Ntandja Wandji Line‐Carolle , Lassailly Guillaume , Louvet Alexandre , Dharancy Sébastien , Mathurin Philippe , Deuffic‐Burban Sylvie 
Published: August 2022

Abstract
To validate cancer screening programs, experts recommend estimating effects on case fatality rates (CFRs) and cancer‐specific mortality. This study evaluates hepatocellular carcinoma (HCC) screening in patients with cirrhosis for those outcomes using a modeling approach. We designed a Markov model to assess 10‐year HCC‐CFR, HCC‐related, and overall mortality per 100,000 screened patients with compensated cirrhosis. The model evaluates different HCC surveillance intervals (none, annual [12 months], semiannual [6 months], or quarterly [3 months]) and imaging modalities (ultrasound [US] or magnetic resonance imaging [MRI]) in various annual incidences (0.2%, 0.4%, or 1.5%). Compared to no surveillance, 6‐month US reduced the 10‐year HCC‐CFR from 77% to 46%. With annual incidences of 0.2%, 0.4%, and 1.5%, the model predicted 281, 565, and 2059 fewer HCC‐related deaths, respectively, and 187, 374, and 1356 fewer total deaths per 100,000 screened patients, respectively. Combining alpha‐fetoprotein screening to 6‐month US led to 32, 63, and 230 fewer HCC‐related deaths per 100,000 screened patients for annual incidences of 0.2%, 0.4%, and 1.5%, respectively. Compared to 6‐month US, 3‐month US reduced cancer‐related mortality by 14%, predicting 61, 123, and 446 fewer HCC‐related deaths per 100,000 screened patients with annual incidences of 0.2%, 0.4%, and 1.5%, respectively. Compared to 6‐month US, 6‐month MRI (−17%) and 12‐month MRI (−6%) reduced HCC‐related mortality. Compared to 6‐month US, overall mortality reductions ranged from −0.1% to −1.3% when using 3‐month US or MRI. A US surveillance interval of 6 months improves HCC‐related and overall mortality compared to no surveillance. A shorter US interval or using MRI could reduce HCC‐CFR and HCC‐related mortality, with a modest effect on overall mortality.
Exploring heterogeneity of national health insurance scheme enrolment among persons in the informal sector
Authors: Sekyi Samuel , Domanban Paul B. , Agbenyo Fauster 
Published: August 2022

AbstractThe Ghanaian government began implementing the National Health Insurance Scheme (NHIS) in 2005, anchored on the universal health coverage principle. However, informal sector workers contribute to the low enrolment into the scheme. This paper examines the factors that influence enrolment status in Ghana's NHIS among individuals in the informal sector. The study employed the fixed‐effects logit model, using the Ghana Socioeconomic Panel Survey datasets. The findings revealed that gender, age, education, marital status, household size, physical activity, income, savings and subjective social welfare determine enrolment decisions of persons in the informal sector. Drivers of NHIS enrolment for male and female household heads were secondary education and household size. Heterogeneously, age, Junior High School education, married, physical activity, subjective social welfare and savings influenced only male‐headed households' enrolment status. The study shows differences in enrolment status among rural and urban residents, as age, education, marital status, household size, and physical activity influenced rural residents, while for urban inhabitants', savings determined their NHIS enrolment decisions. However, gender, obesity, income and subjective social welfare predicted enrolment decisions for rural and urban residents. Finally, two variables, gender (male) and physical activity predicted the NHIS enrolment decision among the poor, whereas subjective social welfare and savings influenced the wealthiest enrolment decisions. For Ghana to achieve the Sustainable Development Goals of universal health coverage, the study recommends enhanced public education on NHIS benefits among informal workers to promote enrolment.
Hydrologic connectivity and source heterogeneity control concentration–discharge relationships
Authors: Knapp Julia L. A. , Li Li , Musolff Andreas 
Published: August 2022

AbstractChanges in streamwater chemistry have frequently been used to understand the storage and release of water and solutes at the catchment scale. Streamwater chemistry typically varies in space and time, depending on sources, mobilization mechanisms, and pathways of water and solutes. However, less is known about the role of lateral hydrologic connectivity and how it may influence streamwater chemistry and solute export patterns under different wetness conditions. This study analyses long‐term low‐frequency data from four UK catchments using antecedent catchment wetness as proxy for lateral hydrologic connectivity. We demonstrate that solute mobilization mechanisms can vary depending on catchment wetness, as different catchment areas become hydrologically connected to or disconnected from streams. We show that flow and streamwater chemistry are mostly decoupled under dry conditions, leading to stronger impacts of the heterogeneity in solute sources on mobilization patterns during dry conditions compared to wet conditions. Our results demonstrate that the lateral and vertical distributions of solutes need to be integrated and considered together with the temporally variable hydrologic connectivity of these lateral areas to the stream when assessing streamwater chemistry. This combined analysis thus enables inferences regarding the lateral distribution of solutes throughout the catchment; it also indicates that a better understanding of the relationship between lateral hydrologic connectivity and the lateral and vertical distributions of solute concentrations can help to identify particularly vulnerable points in the catchment and their potential polluting effects on streams.
Contralateral C7 nerve transfer in the treatment of central hemiplegia after stroke under general anesthesia: A case report
Authors: Zhang Qiu‐Ying , Guo Yi , Zhang Yi‐Nan 
Published: August 2022

AbstractSimilar reports in the past pay less attention to the anesthetic management of these patients. We reported a 46‐year‐old man who suffered from hypertensive cerebral apoplexy 5 months ago and accepted C7 nerve transfer to improve the central spastic paralysis in the right upper limb. After careful evaluation and anesthesia management before anesthesia, the operation was successfully completed under general anesthesia. The patient was cured and discharged without complications. The anesthesia management of C7 nerve transfer should choose appropriate operation opportunities for patients according to the type of stroke, improve the preoperative preparation, and form a multidisciplinary diagnosis and treatment.
Count Roy model with finite mixtures
Authors: Munkin Murat K. 
Published: August 2022

SummaryThis paper develops the Finite Mixture Roy model for count variables and uses this semiparametric model to analyze the effect of supplemental Medigap private insurance on the demand for prescription drugs for the U.S. elderly unemployed Medicare population. The model is an extension of the Count Roy model, which produces unrealistic treatment effects when observed count patterns are consistent with finite mixtures. To estimate the numbers of components in the mixtures for individuals with and without Medigap, this paper adopts the random permutation sampler. The considered application motivates two additional features of the model. Specifically, the smoothly mixing regression approach is utilized to model the probabilities of the components, and a continuous instrumental variable is allowed to enter the treatment equation nonparametrically. Strong evidence is found that there are two components both in the treated and untreated states. These lower and higher utilization components are interpreted as relatively healthy and unhealthy groups. The estimated treatment effects show that Medigap insurance provides incentives to increase prescription drug utilization by 2%. The results are consistent with adverse selection.
Charge order and structure transformation of hydrated cesium cobaltates revealed by variable‐temperature 133Cs NMR spectroscopy
Authors: Lin Eugene C. , Chen Ting‐Hao , Chen Pin‐Chen , Liao Ming‐Yuan 
Published: August 2022

AbstractVariable temperature 133Cs‐NMR experiments were performed to probe the local environment of the cesium ions in hydrated cesium cobaltates (Cs0.2CoO2·0.63H2O) from 170 to 390 K. Temperature dependence of the chemical shifts and linewidths reveals two‐phase transitions at a temperature near 200 and 350 K. Three inequivalent cesium sites are observed as the temperature is reduced below 200 K, indicating restricted motion of the cesium ions and a tendency to electron localization on cobalt ions. The results provide evidence for a definite order of the cesium ions and the charge order of the cobalt ions in the CoO2 layers. Two inequivalent cesium sites with larger chemical shift differences are observed as the temperature is above 350 K, indicating a spectacular change in the space between the CoO2 planes, which provides evidence for the transition between the bilayer‐hydrated and monolayer‐hydrated structures.
Psychological characteristics of Japanese patients and their family members receiving genetic counseling: A single‐institute exploratory study
Authors: Mochiki Ikuyo , Okugawa Yoshinaga , Hashizume Ryotaro , Imai Hiroshi , Ikejiri Makoto , Ogura Toru , Nakatani Kaname , Hori Hiroki 
Published: August 2022

AbstractIn Japan, clinical genetic services became available in the 1970s, and genomic medicine, including genetic counseling (GC), developed rapidly. However, research on the outcomes of GC in Japan is limited. Japan has a unique cultural context, and appropriate GC methods have not yet been optimized for this population. The current study aimed to evaluate the psychological status of Japanese patients and their companions undergoing GC and the outcomes of GC. We used the Quality of Care Through the Patients' Eyes‐gene cancer (QUOTE‐geneCA), the Genetic Counseling Outcome Scale‐24 (GCOS‐24), and the State‐Trait Anxiety Inventory (STAI) to evaluate patients and their companions' needs and preferences regarding GC, empowerment, and anxiety, respectively. We evaluated stress status during GC by measuring saliva cortisol levels. QUOTE‐geneCA results for patients (n = 69) and a group of patients and their companions (n = 96) revealed that participants felt that it was important that skilled medical staff explained medical information and provided advice in an easily understandable manner. Japanese patients and their companions regarded the procedural aspects of counseling as most important and their autonomy in decision‐making as less important. GCOS‐24 results revealed a significant increase in empowerment scores in 38 patients (by 9.63 points) from pre‐ to post‐GC (p < 0.001; Cohen's d = 0.79). STAI results revealed a significant decrease in state anxiety for patients (6.11 points; p < 0.001; Cohen's d = 0.66). Cortisol levels in patients significantly decreased after GC (p = 0.001). The improvement of empowerment scores from pre‐ to post‐GC among patients and their companions were significantly negatively correlated with pre‐GC empowerment scores (p < 0.001), trait anxiety scores (p = 0.001), and the number of people living together (p = 0.011). The change of cortisol levels during GC in patients and their companions was significantly positively correlated with trait anxiety score (p = 0.027). This study suggested that these characteristics of Japanese patients and their companions may predict GC outcomes.
Symptomatology and microbiology of the gastrointestinal tract in post‐COVID conditions
Authors: Norouzi Masir Mohamad , Shirvaliloo Milad 
Published: August 2022

AbstractPost‐COVID conditions, also known as post‐acute sequelae of SARS‐CoV‐2 (PASC), refer to the persistence of symptoms in COVID‐19 long‐haulers. Various manifestations of post‐COVID conditions are general symptoms and/or manifestations of damage in multiple organs. Besides, SARS‐CoV‐2 can involve the gastrointestinal tract, resulting in sequelae such as diarrhea, abdominal pain, nausea, anorexia, vomiting, constipation, abdominal distension, acid reflux, and/or gastrointestinal bleeding. Previous investigations point to SARS‐CoV‐2 entry into enterocytes enhances by the angiotensin‐converting enzyme 2 (ACE2) receptors. Interestingly, ACE2 receptors are abundantly expressed in the gut, implying infection with SARS‐CoV‐2 might occur through this route as well as in the respiratory tract. According to mounting evidence, SARS‐CoV‐2 RNA has been identified in fecal specimens of patients with COVID‐19 during and beyond the acute phase. In addition, studies have shown gut microbiome composition is altered in patients with PASC, hence, another putative mechanism linked to gastrointestinal symptoms is gut dysbiosis. The presence of the gut‐lung axis in COVID‐19 might have major implications for disease pathogenesis and treatment. This review discussed the prevalence of gastrointestinal symptoms and pathophysiology underlying possible infection of the gut in patients with PASC. Also, SARS‐COV‐2 induced NLRP3 inflammasome‐dependent inflammatory pathways are briefly addressed.
A multi‐country cross‐sectional study to assess predictors of daily versus on‐demand oral pre‐exposure prophylaxis in youth from South Africa, Uganda and Zimbabwe
Authors: Dietrich Janan Janine , Ahmed Nadia , Webb Emily L. , Tshabalala Gugulethu , Hornschuh Stefanie , Mulaudzi Mamakiri , Atujuna Millicent , Stranix‐Chibanda Lynda , Nematadzira Teacler , Ssemata Andrew Sentoogo , Muhumuza Richard , Seeley Janet , Bekker Linda‐Gail , Weiss Helen A. , Martinson Neil , Fox Julie ,   the CHAPS team
Published: August 2022

AbstractIntroductionSub‐Saharan Africa (SSA) carries the burden of the HIV epidemic, especially among adolescents and young people (AYP). Little is known about pre‐exposure prophylaxis (PrEP) uptake and preferences among AYP in SSA. We describe preferences for daily and on‐demand PrEP among AYP in South Africa, Uganda and Zimbabwe.MethodsA cross‐sectional survey was conducted in 2019 among 13‐ to 24‐year olds, capturing socio‐demographics, HIV risk behaviours and preferences for daily or on‐demand PrEP. Logistic regression models were used to estimate odds ratios, adjusting for site, sex and age.Results and discussionA total of 1330 participants from Cape Town (n = 239), Johannesburg (n = 200), Entebbe (n = 491) and Chitungwiza (n = 400) were enrolled; 673 (51%) were male, and the median age was 19 years (interquartile range 17–22 years). Of 1287 participants expressing a preference, 60% indicated a preference for on‐demand PrEP with differences by site (p < 0.001), sex (p < 0.001) and age group (p = 0.003). On‐demand PrEP was most preferred in Entebbe (75%), among males (65%) versus females (54%) and in older participants (62% in 18‐ to 24‐year‐olds vs. 47% in 13‐ to 15‐year‐olds). After adjusting for site, sex and age group, preference for on‐demand PrEP decreased as sex frequency over the past month increased (p‐trend = 0.004) and varied with the number of partners in the last 6 months, being least popular among those reporting four or more partners (p = 0.02). Participants knowing further in advance that they were likely to have sex were more likely to prefer on‐demand PrEP (p‐trend = 0.02). Participants having a larger age gap with their most recent partner and participants whose last partner was a transactional sex partner or client were both less likely to prefer on‐demand compared to daily PrEP (p = 0.05 andp = 0.09, respectively). Participants who knew their most recent partner was living with HIV or who did not know the HIV status of their most recent partner were less likely to prefer on‐demand PrEP (p = 0.05).ConclusionsOur data show that AYP in four SSA communities prefer on‐demand over daily PrEP options, with differences seen by site, age and sex. PrEP demand creation needs to be reviewed, optimized and tailored to socio‐demographic differences and designed in conjunction with AYP.
The melatonin contained in beer can provide health benefits, due to its antioxidant, anti‐inflammatory and immunomodulatory properties
Authors: Maldonado MDolores , Romero‐Aibar Jerusa , Calvo JRamón 
Published: August 2022

AbstractBeer is a fermented beverage with a low alcohol content originating from cereal fermentation (barley or wheat). It forms part of the diet for many people. It contains melatonin (N‐acetyl‐5‐methoxytryptamine). Melatonin is a molecule with a wide range of antioxidant, oncostatic, immunomodulatory, and cytoprotective properties. The aim of this work was to review the data supporting the idea that a moderate consumption of beer, because of its melatonin content, is particularly useful in healthy diets and in other physiological situations (such as pregnancy, menopause, and old age). Data source: a) The MEDLINE /PubMed search was conducted from 1975 to April 2022, and b) Our own experience and published studies on melatonin, the immune system, and beer. We provide a review of research on the mechanisms of melatonin generation in beer, its concentrations, and its possible effects on health. The melatonin contained in beer, as part of a healthy diet and in some special physiological situations, could act as a protective factor and improve the quality of life of those who drink it in moderation. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Impact of dietary supplementation with N‐carbamoyl‐aspartic acid on serum metabolites and intestinal microflora of sows
Authors: Gao Lu‐min , Liu Gang‐yi , Wang Hong‐ling , Wassie Teketay , Wu Xin , Yin Yu‐long 
Published: August 2022

AbstractBackgroundN‐Carbamoyl‐aspartic acid (NCA) is a critical precursor for de novo biosynthesis of pyrimidine nucleotides. To investigate the cumulative effects of maternal supplementation with NCA on the productive performance, serum metabolites and intestinal microbiota of sows, 40 pregnant sows (∼day 80) were assigned into two groups: (1) the control (CON) and (2) treatment (NCA, 50 g t−1 NCA).ResultsResults showed that piglets from the NCA group had heavier birth weight than those in the CON group (P < 0.05). In addition, maternal supplementation with NCA decreased the backfat loss of sows during lactation (P < 0.05). Furthermore,16S‐rRNA sequencing results revealed that maternal NCA supplementation decreased the abundance of Cellulosilyticum, Fournierella, Anaerovibrio, and Oribacterium genera of sows during late pregnancy (P < 0.05). Similarly, on the 14th day of lactation, maternal supplementation with NCA reduced the diversity of fecal microbes of sows as evidenced by significantly lower observed species, Chao1, and Ace indexes, and decreased the abundance of Lachnospire, Faecalibacterium, and Anaerovorax genera, while enriched the abundance of Catenisphaera (P < 0.05). Untargeted metabolomics showed that a total of 48 differentially abundant biomarkers were identified, which were mainly involved in metabolic pathways of arginine/proline metabolism, phenylalanine/tyrosine metabolism, and fatty acid biosynthesis, etc.ConclusionOverall, the results indicated that NCA supplementation regulated intestinal microbial composition of sows and serum differential metabolites related to arginine, proline, phenylalanine, tyrosine, and fatty acids metabolism that may contribute to regulating the backfat loss of sows, and the birth weight and diarrhea rate of piglets. © 2022 Society of Chemical Industry.
Photochemistry of Azide‐Functional Polymers: Soluble Sulfoximine Polymers through Selective Nitrene–Sulfoxide Addition
Authors: Li Yuman , Bakar Rohani Abu , Roth Peter J. 
Published: August 2022

AbstractOrganic azides are a common functional group in polymer chemistry. Upon irradiation, they form nitrenes which are usually exploited for crosslinking based on their “universal” reactivity allowing insertion into nearby C–H bonds. Herein, it is demonstrated that polymer‐bound perfluorophenyl azide groups selectively form sulfoximines when irradiated in the presence of an excess of sulfoxide, without observable crosslinking. Poly(4‐azido‐2,3,5,6‐tetrafluorobenzyl methacrylate) (carrying an azide group in every repeat unit) is prepared through azide–para‐fluoro postpolymerization modification of a 2,3,4,5,6‐pentafluorobenzyl‐functional precursor. Samples of the azide‐functional polymer are irradiated (λmax= 254 nm) in dichloromethane in the presence of varying amounts of five different sulfoxides. Products are characterized by1H and19F NMR spectroscopy, Fourier transform infrared spectroscopy, size exclusion chromatography, and differential scanning calorimetry. Irradiations for 7 h with a 40–70‐fold molar excess of sulfoxides gave soluble products with azide‐to‐sulfoximine conversions of 89–96%. This first example of a selective nitrene‐based reaction in the polymer arena shows that sulfoxide solvents must be avoided if crosslinking is desired and provides access to novel sulfoximine‐functional materials.
mRNA vaccines in the prevention and treatment of diseases
Authors: Gu Yangzhuo , Duan Jiangyao , Yang Na , Yang Yuxin , Zhao Xing 
Published: August 2022

AbstractMessenger ribonucleic acid (mRNA) vaccines made their successful public debut in the effort against the COVID‐19 outbreak starting in late 2019, although the history of mRNA vaccines can be traced back decades. This review provides an overview to discuss the historical course and present situation of mRNA vaccine development in addition to some basic concepts that underly mRNA vaccines. We discuss the general preparation and manufacturing of mRNA vaccines and also discuss the scientific advances in the in vivo delivery system and evaluate popular approaches (i.e., lipid nanoparticle and protamine) in detail. Next, we highlight the clinical value of mRNA vaccines as potent candidates for therapeutic treatment and discuss clinical progress in the treatment of cancer and coronavirus disease 2019. Data suggest that mRNA vaccines, with several prominent advantages, have achieved encouraging results and increasing attention due to tremendous potential in disease management. Finally, we suggest some potential directions worthy of further investigation and optimization. In addition to basic research, studies that help to facilitate storage and transportation will be indispensable for practical applications.
Generalized‐α scheme in the PFEM for velocity‐pressure and displacement‐pressure formulations of the incompressible Navier–Stokes equations
Authors: Fernández Eduardo , Février Simon , Lacroix Martin , Boman Romain , Ponthot Jean‐Philippe 
Published: August 2022

AbstractDespite the increasing use of the particle finite element method (PFEM) in fluid flow simulation and the outstanding success of the Generalized‐ (GA) time integration method, very little discussion has been devoted to their combined performance. This work aims to contribute in this regard by addressing three main aspects. First, it includes a detailed implementation analysis of the GA method in PFEM. The work recognizes and compares different implementation approaches from the literature, which differ mainly in the terms that are ‐interpolated (state variables or forces of momentum equation) and the type of treatment for the pressure in the time integration scheme. Second, the work compares the performance of the GA method against the Backward Euler and Newmark schemes for the solution of the incompressible Navier–Stokes equations. Third, the study is enriched by considering not only the classical velocity‐pressure formulation but also the displacement‐pressure formulation that is gaining interest in the fluid‐structure interaction field. The work is carried out using various 2D and 3D benchmark problems such as the fluid sloshing, the solitary wave propagation, the flow around a cylinder, and the collapse of a cylindrical water column.