bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cystic malformation (lymphangioma) of the thoracic lymphatic duct (peculiarities of clinical and radiological diagnosis, a brief review)
Authors: Lenshin A. V. , Il’in A. V. , Ignat’eva E. A. , Kraynov S. A. , Perelman J. M. 
Published: April 2022

Introduction. The thoracic lymphatic duct in the upper half of the body collects lymph from the left lung, the left half of the heart, the walls of the left half of the chest, from the left upper limb and the left half of the neck and head. Therefore, the left-sided localization of the revealed pathological changes, with the involvement of the mediastinum and neck in the process at the same time, can be a sign of damage to the thoracic lymphatic duct (at the location), and therefore the key to a successful diagnosis of the disease. Aim. Demonstration of modern possibilities of clinical and radiological diagnosis of cystic malformation of the thoracic lymphatic duct (CMTLD). Results. In the literature, the pathology of the thoracic lymphatic duct is designated by two terms: “lymphangioma” and “cystic malformation of the thoracic lymphatic duct”. According to the generally accepted classification of vascular formations ISSVA (adopted at the 20th ISSVA conference in Melbourne in April 2014, last revised in May 2018), the term “lymphangioma” with regard to lymphatic malformations is considered obsolete, its use is recommended for true benign tumors of the lymphatic vessels. CMTLD – benign, extremely rare lymphovascular lesions resulting from embryological disorders (weakness of the duct wall and valve mechanism) in the development of the lymphatic system. The median prevalence is less than 1 % among all mediastinal cystic formations. Effective non-invasive diagnostics at the initial visit of the patient already at the outpatient stage deserves professional evaluation. We present the own clinical and radiological observation of a 26-year-old patient without any special clinical manifestations, in whom volumetric changes in the mediastinum on the left were detected during routine fluorography. The nature (X-ray semiotics) of preoperative imaging using computed tomography has been clarified. The revealed X-ray and pathoanatomical changes were compared. Conclusion. CMTLD – congenital lymphatic anomalies, more frequent and symptomatic in children. In older patients, acquired and asymptomatic CMTLD are most often diagnosed. The logistics of modern imaging technologies makes it possible to successfully diagnose such a rare disease as CMTLD already at the stage of the patient’s initial visit to the doctor.
COVID-19-associated dyslipidemia: the role of lipid and fatty acids in the pathogenesis of SARS-CoV-2 infection
Authors: Sinyakin I. А. , Аndrievskaya I. А. , Ishutina N. А. , Smirnova N. А. 
Published: April 2022

Introduction. The COVID-19 pandemic is a global public health problem. In COVID-19, systemic inflammation is accompanied by a “cytokine storm”, hypercoagulability, and generalized vasculitis, and new evidence suggests that lipid transportation disorders may exacerbate the course of the disease. Aim. Discussion of the role of lipids, fatty acids, and various cascade molecular pathways in the pathogenesis of COVID-19-associated dyslipidemia. Results. When conducting a systematic analysis of the scientific literature in the PubMed database, we concluded the following: lipoproteins, oxidized forms of phospholipids and fatty acids can lead to organ damage due to hyperactivation of scavenger of the innate immune response. Thus, restoring lipoprotein function with agents that increase apolipoprotein A-I levels or blocking the relevant scavenger receptors with neutralizing antibodies may be effective in the treatment of COVID-19. The key role of lipoprotein-transported omega-3 fatty acids in the production of specialized proreactive mediators has been demonstrated, and activation of the leukotriene pathway has been shown to be associated with the severity of COVID-19. Conclusion. A growing number of scientific studies indicates that lipid and fatty acids have both positive and negative effects in SARS-CoV-2 infection. Additional studies or preclinical models evaluating the eicosanoid profile in patients with COVID-19 will provide new insights into the interaction of the coronavirus with “the host” and the regulation of the inflammatory response.
Some features of the transmission of covid-19 infection in the child population (review)
Authors: Lazareva M. A. , Evseeva G. P. , Suprun S. V. , Lebed’ko O. A. 
Published: April 2022

Introduction. During the first wave of the pandemic COVID-19, there was limited and poor quality information on the contribution of children to the transmission of SARS-CoV-2. By early August 2020, several confirmed cases of transmission from children had been published, with no clear evidence that the frequency of transmission from children is higher than that of adults. Since the beginning of the pandemic, children have accounted for 18.4 % of the total number of registered cases, and at the beginning of January 2022, 25.5 % of the total number of COVID-19 cases. Most of the new cases of the disease are Omicron strains. Even with the predicted generally less severe illness resulting from Omicron infection in children, doctors fear that more children may be hospitalized in the coming weeks, given the ever-increasing number of cases of infection with the virus. Data on the risk of SARS-CoV-2 infection among children compared with adults is needed to inform COVID-19 risks and prevention strategies, including COVID-19 childhood vaccination policy. Aim. To display literature data containing a review of studies on the transmission of coronavirus infection in children; to analyze the features of the vertical transmission route. Materials and methods. An analysis was made of publications containing data from studies of cases and features of the transmission of COVID-19 disease in children, including from mother to child. Results. Currently, foreign sources note several options for the transmission of SARS-CoV-2 in children. SARS-CoV-2 infection during pregnancy may affect pregnancy outcome, delivery, and the birth of a potentially infected baby. Conclusion. Data on the risk of infection and possible routes of transmission of SARS-CoV-2 in children, including vertical transmission, are needed to improve prevention methods, including immunization of pregnant women and children.
Influence of N-acyl-ethanolamine of arachidonic acid on the synthesis of cytokines and oxylipins by the blood leukocytes of patients with asthma under <i>in vitro</i> conditions
Authors: Denisenko Yu. K. , Bocharova N. V. , Kovalenko I. S. , Novgorodtseva T. P. 
Published: April 2022

Introduction. The search for hihly effective methods for the treatment and control of asthma remains an urgent task of modern pathophysiology and pharmacology. N-acyl-ethanolamines of arachidonic acid (NAE 20: 4) are promising biomolecules for the regulation of the immune processes. Aim. To investigate the in vitro influence of NAE 20: 4 on the immune cells' ability from patients with asthma to synthesize pro-inflammatory cytokines and oxylipins. Materials and methods. The objective of the study was the blood of 11 patients with mild controlled asthma and 10 healthy volunteers. The in vitro experiment was carried out in stimulated and not stimulated by lipopolysaccharide (LPS) blood for 6 hours. NAE 20: 4 was added at 1.0 µM, 3.0 µM or 10.0 µM doses. The levels of cytokines (TNFα, IL-8), thromboxaneB2 (TXB2) and leukotriene B4 (LTB4) were analyzed by the ELISA method. Results. We found an increase in TNFα, IL-8, TXB2, LTB4 in the blood of persons with asthma before in vitro NAE 20: 4 exposure, which indicates systemic chronic inflammation. Incubation of blood cells without LPS did not affect the change in the spectrum of mediators studied. Whereas the treatment of NAE 20: 4 at a 10 µM reduced the synthesis of TNFα, IL-8, LTB4, TXB2. In vitro blood cells stimulation by LPS led to hyperproduction of cytokines and oxylipins. NAE 20: 4 at a dose of 1 µM in LPS-stimulated blood had no effect on the production of signaling molecules, while NAE 20:4 at a concentration of 3 µM reduced the level of TNFα, IL-8. NAE 20:4 at a dose of 10.0 µM inhibited the cytokines and LTB4 synthesis. The level of TXB2 underthe influence of NAE 20: 4 at 10.0 µM did not change. Conclusion. The results of the study revealed a dose-dependent anti-inflammatory effect of NAE 20:4, characterized by its ability to influence the synthesis of pro-inflammatory cytokines and oxylipins by the immune cells of individuals with asthma in vitro. Further study of NAE 20: 4 opens up new prospects for the development of targeted methods for regulating immune processes in asthma.
Association between the clinical-functional parameters and lipid markers of systemic inflammation in mild asthma complicated with obesity
Authors: Uksumenko A. A. , Antonyuk M. V. , Denisenko Yu. K. , Yurenko A. V. , Mineeva E. E. 
Published: April 2022

Aim. To identify the features of the association between the clinical-functional conditions and lipid markers of systemic inflammation (fatty acids, eicosanoids, plasmalogens) of patients with mild asthma and obesity. Materials and methods. Obese (n=80) and nonobese (n = 55) adults with mild, partially controlled asthma aged 28 to 65 years, and nonobese (n = 30) healthy controls had venous blood samples analysed. The ACQ-5 test, spirometry were evaluated. Serum thromboxane B2 (ТХВ2) and leukotriene B4 (LTB4) were analyzed by the enzyme immunoassay method. Fatty acidsas methyl esters (FAMEs) and plasmalogens in the form of dimethyl acetals (DMA) were estimated in blood plasma by gas chromatography-mass spectrometry. Results. In obese patients with asthma, the ACQ-5 test was lower in comparison to nonobese patients. FEV1 decreased by 8 %, FVC by 12% (p < 0.05). A decrease in the level of DMA16: 0 by 17.5 % and DMA18: 0 by 25 % was established in obese asthma patients. The ratio of DMA16:0/FAME 16: 0 declined by 21 %, DMA18:0/FAME18: 0 − by 28 %. A fall in eicosapentaenoic acid (20: 5n3) and a change in the 20:4n6/20:5n3 ratio were found. The level of ТХВ2 and LTB4 was increased regardless of body weight. There was a positive correlation between body mass index and levels of LTB4 (r = 0.46), ТХВ2 (r = 0.49); and a negative correlation between ACQ and ТХВ2 (r = - 0.58). Indicators of lung function (FEV1, FVC, VC) had correlative links with DMA18:0, DMA20:0, eicosapentaenoic acid. Conclusion. We showed the change in the inflammatory fatty acids and eicosanoids synthesis and plasmalogen deficiency in obese-asthma. Established relationships between clinical and functional parameters and lipid markers of systemic inflammation, plasmalogen deficiency in patients with asthma and obesity reveal new pathogenetic mechanisms of the systemic inflammatory process in chronic respiratory diseases.
Possibilities of syndrome-oriented medical rehabilitation in diseases of the respiratory organs in the resort of the Southern coast of Crimea
Authors: Yanovskiy T. S. , Dudchenko L. Sh. , Mizin V. I. , Maslikova G. G. , Beliaeva S. N. , Shilina D. A. 
Published: April 2022

Aim. To evaluate the possibilities of physiotherapeutic syndrome-oriented medical rehabilitation (MR) for lung diseases (LD) in the climatic resort of the Southern Coast of Crimea (SCC). Materials and methods. In a single-center retrospective observational study, an analysis was made of the rehabilitation effects of physiotherapeutic interventions in a contingent of 100 patients with LD. Examination and treatment of patients was carried out in accordance with the standard of health resort care for patients with LD. Additionally, psychological studies and therapeutic effects were carried out by transcranial electrical stimulation, dynamic electrical nerve stimulation, mud therapy with Saki therapeutic mud, aromatherapy with sage oil and breathing training with a breathing simulator “New Breath”. The assessment of the values of 23 domains of “International Classification of Functioning, Disability and Health” (ICF) was carried out according to the methodology developed in the “ARI n.a. I.M.Sechenov”. The values of domains at the beginning and at the end of the MR course were evaluated, as well as the dynamics of domains (equal to the result of subtracting the values of the domain at the end of the course from the value at the beginning of the course). Mathematical analysis of the obtaineddata was carried out using the methods of multivariate statistics. Results. A statistically significant (at p < 0.05) positive dynamics of a number of domains was established, indicating the success of a comprehensive course of MR, including domains b2401, b410, b420, b450, b455, b4552, b4601 and an integrated assessment of the functional state (IAFS). The 18 equations of the positive effect of course doses of physiotherapeutic procedures (alternating magnetic field, DENS, ultrasound therapy, halotherapy, inhalation therapy, aromatherapy, pelopathy, short-wave ultraviolet irradiation and massage) on the effectiveness of MR for 12 domains and for IAFS were obtained. Conclusion. The use of ICF domains as rehabilitation syndromes is substantiated. The complex of physiotherapeutic influences used in the treatment of patients with LD in the SCC climatic resort has significant potential for successful syndrome-oriented MR.
Lymphocyte-platelet adhesion, eosinophil and IgE ige concentration in children with obstructive bronchitis
Authors: Vlasova A. N. , Vitkovsky Yu. A. 
Published: April 2022

Aim. To study lymphocytic-platelet adhesion, eosinophils and IgE concentration in children with acute obstructive bronchitis. Materials and methods. 70 children were examined, the first group consisted of children with acute bronchitis (n=38), the second group included healthy children (n=32). All children were examined for the concentration of IgE, the number of lymphocytes and eosinophils, and the count of lymphocyte-platelet aggregates. Results. In patients with obstructive bronchitis, there was no difference in the concentration of the relative and absolute number of lymphocytes compared with healthy children. High values of eosinophils were found in children with obstructive bronchitis (9.0 ± 0.7 %) while in children of the control group the same indicator was determined within the limits of normal values (0.9 ± 0.2 %). The level of IgE in children with obstructive bronchitis exceeded the concentration of this indicator in healthy children by 19 times. In children with obstructive bronchitis, the index and degree of lymphocyticplatelet adhesion were 20.0 ± 0.7 % and 10.5 ± 0.09, respectively, statistically significantly higher than similar indices in healthy children (14.0 ± 0.2 %, p = 0.0001 and 3.3 ± 0.1, p = 0.001, respectively). Conclusion. In the body of children with obstructive bronchitis, an immune response develops, which is involved in the pathogenesis of recurrence of the disease, the causes of which are infectious agents that stimulate innate immunity due to the presentation of PAMP molecules, as well as adaptive immunity, accompanied by killer reactions, the production of immunoglobulins, including IgE.
Interrelation of immunological and hemodynamic parameters of the fetoplacental system in exacerbation of chronic bronchitis of cytomegalovirus etiology
Authors: Kolosov V. P. , Gorikov I. N. , Andrievskaya I. A. , Odireev A. N. , Nakhamchen L. G. , Bushmanov A. V. 
Published: April 2022

Aim. To establish the relationship of immunological and hemodynamic parameters of the fetoplacental system during exacerbation of chronic bronchitis of cytomegalovirus etiology. Materials and methods. A study was carried out of the concentration of TNFα, IgA, IgM in the blood serum and the systolic-diastolic ratio (SDR) in the right uterine artery (RUA) in 80 women in the second trimester of pregnancy, uncomplicated and complicated by exacerbation of cytomegalovirus infection (CMVI). Three groups were retrospectively distinguished. The first group included 30 patients with CMV seronegative physiological pregnancy, the second group included 25 women with exacerbation of chronic bronchitis caused by CMVI reactivation, initiating the development of chronic compensated placental insufficiency (CCPI), in the third group – 25 pregnant women with chronic bronchitis in the acute stage, induced by CMVI, leading to the formation of chronic subcompensated placental insufficiency (CSPI) in the third trimester of gestation. Results. In the first group, the concentration of TNFα in the blood serum was Me 16.4 (13.1–33.8) pg/mL, IgA – Me 2.5 (2.23–2.62) mg/mL, IgM – Me 0.99 (0.87–1.56) mg/mL, and SDR in RUA – Me 1.95 (1.87–2.30). In the second group, compared with the first one, there was an increase in the concentration of TNFα by 4.95 times (p=0.000001), IgM − by 2.51 times (p = 0.000001) and SDR in RUA by 1.25 times (p = 0.000001) with a 1.49-fold decrease in the IgA level (p = 0.000001). In the third group, compared with the first one, there was an increase in TNFα by 6.12 times (p = 0.000001), IgM − by 2.98 times (p = 0.000001) and the value of SDR in RUA by 1.70 times (p = 0.000001) against the background of a 2.31-fold decrease in IgA concentration (p = 0.000001). In patients of the third group, in comparison with the second group, higher levels of TNFα (by 1.23 times, p = 0.000001), IgM (by 1.18 times, p = 0.000001) and SDR in the RUA (by 1.35 times, p = 0.000001), as well as lower values of the IgA concentration (1.54 times, p = 0.000001). Conclusion. In women with exacerbation of chronic bronchitis caused by CMVI reactivation, leading to the formation of CSPI, in contrast to patients with a similar bronchopulmonary pathology of cytomegalovirus origin and the development of CCPI, a more pronounced activation of the systemic inflammatory response and an imbalance in the humoral component of immune system lead to an increase in vascular resistance in the RUA pool.
Disturbance of utero-placental-fetus blood flow in pregnant women with community-acquired pneumonia of bacterial and viral (COVID-19) etiology
Authors: Аbuldinov А. S. , Аndrievskaya I. А. 
Published: April 2022

Introduction. Placental insufficiency is one of the most frequently developing complications in pregnant women with acute respiratory failure, which is a consequence of community-acquired pneumonia (CAP), including viral etiology. The impact of COVID-19 infection on the course of pregnancy, the condition of the fetus and newborns has not been studied enough. Aim. To study the state of uteroplacental-fetal circulation, placenta and fetus in women with bacterial and COVID-19-associated CAP in the second and third trimesters of pregnancy. Materials and methods. The history of childbirth and the results of examinations of 120 women in the second and third trimesters of pregnancy were analyzed, including 37 women with moderate CAP of bacterial etiology, 48 women with COVID-19 infection. The comparison group consisted of 35 women with uncomplicated pregnancy. The state of the placenta and fetus was assessed according to the data of ultrasound and utero-placental-fetal blood flow – Doppler study. Pulsation indices (PI) and cerebro-placental ratio (CPR) were analyzed. Results. According to our data, the risk of developing chronic placental insufficiency in pregnant women with COVID-19-associated CAP of moderate severity was higher than in groups of women with CAP of bacterial etiology and in the comparison group. In groups with CAP, significant differences were found in the indices of CPR, PI of the uterine arteries, umbilical cord arteries and middle cerebral artery, corresponding to I (A, B) or II degree of disturbance of the uteroplacental and/or placental-fetal blood flow. Chronic intrauterine fetal hypoxia and fetal growth retardation were more frequently detected in the group with COVID-19-associated CAP. Newborns born to mothers with COVID-19 infection have an increased risk of neonatal damage to the central nervous system (CNS). Conclusion. COVID-19-associated CAP, compared with CAP of bacterial etiology, increases the risk of chronic placental insufficiency, intrauterine fetal hypoxia and fetal growth retardation, and the development of neonatal CNS damage.
Assessment of the main indicators of morbidity and mortality in cancer patients with oral lesions in the eastern regions of Russia
Authors: Gordienko V. P. , Filippova Е. V. 
Published: April 2022

Over the past decades, the eastern regions of Russia are characterized by a constant in-crease in the number of patients with oncological pathology, in the structure of which malignant neoplasms of the respiratory system occupy the first place in the cause of death. Aim. A scientific assessment of the main indicators of morbidity and mortality of the population from the cancer of oral organs in the Far East of Russia (2008-2020). Materials and methods. The morbidity and mortality rates, reporting forms of statistical records of cancer patients and regulatory documents of superior organizations, information on observations of the dynamics of changes in the numerical values of the pathology under study were used in the course of the work. Results. We present the main indices of morbidity and mortality of patients with oral cancer in the eastern regions of the Russian Federation where 596 new cases of malignant neoplasms were registered in 2020, which is 53.7 % more than thirteen years ago (in 2008 – 320 people). There was a similar increase of 76.7 % for Russia. During the studied period of time the number of patients with I-II stages of disease has increased (in 2020 – 39.5 %; in 2008 – 27.6 %) with simultaneous increase of the number of patients with advanced forms of the disease (in 2020 – 33.7 %; in 2008 – 25.9 %). In recent years the morbidity and mortality rates have been steadily increasing. The percentage of actively diagnosed patients has declined (in 2020 – 23.5 %; in 2019 – 24.3 %), while at the end of the year contingent accumulation index has become higher (4.5 %). Morphological confirmation of the diagnosis (over 95.4 %) did not exceed the national average (98.3 %). The ratio of patients who had been on the registry for 5 and more years was lower than the average Russian values, but the mortality rate during the first year after the diagnosis has improved (in 2020 – 28.0 %; in 2008 – 42.0 %). Conclusion. Thus, against the background of increasing total number of patients with malignant neoplasms in the territories of the eastern regions of the Russian Federation there is a steady increase in morbidity and mortality in oral cancer.