bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Conditioning Lesion Response in Dorsal Root Ganglion Neurons Is Inhibited in Oncomodulin Knock-Out Mice
Authors: Niemi Jon P. , DeFrancesco-Oranburg Talia , Cox Andrew , Lindborg Jane A. , Echevarria Franklin D. , McCluskey Jemima , Simmons Dwayne D. , Zigmond Richard E. 
Published: February 2022

AbstractRegeneration can occur in peripheral neurons after injury, but the mechanisms involved are not fully delineated. Macrophages in dorsal root ganglia (DRGs) are involved in the enhanced regeneration that occurs after a conditioning lesion (CL), but how macrophages stimulate this response is not known. Oncomodulin (Ocm) has been proposed as a proregenerative molecule secreted by macrophages and neutrophils, is expressed in the DRG after axotomy, and stimulates neurite outgrowth by DRG neurons in culture. Wild-type (WT) andOcmknock-out (KO) mice were used to investigate whether Ocm plays a role in the CL response in DRG neurons after sciatic nerve transection. Neurite outgrowth was measured after 24 and 48 h in explant culture 7 d after a CL. Sciatic nerve regeneration was also measuredin vivo7 d after a CL and 2 d after a subsequent sciatic nerve crush. The magnitude of the increased neurite outgrowth following a CL was significantly smaller in explants fromOcmKO mice than in explants from WT mice.In vivoafter a CL, increased regeneration was found in WT animals but not in KO animals. Macrophage accumulation and levels ofinterleukin-6(IL-6) mRNA were measured in axotomized DRG from WT andOcmKO animals, and both were significantly higher than in sham-operated ganglia. At 6 h after axotomy,Il-6 mRNA was higher in WT than inOcmKO mice. Our data support the hypothesis that Ocm plays a necessary role in producing a normal CL response and that its effects possibly result in part from stimulation of the expression of proregenerative macrophage cytokines such as IL-6.
Characterization of hyperlipidemia secondary to mitotane in adrenocortical carcinoma
Authors: Gagnon Nadia , Bernard Sophie , Paquette Martine , Alguire Catherine , Lacroix André , Hétu Pierre-Olivier , Olney Harold J , Bourdeau Isabelle 
Published: February 2022

Background
This study examined the magnitude of changes and the time required to observe maximal changes in LDL-c, HDL-c, triglycerides (Tg) and non-HDL-c after the introduction of mitotane.

Methods
Retrospective study of 45 patients with adrenocortical carcinoma who were treated at the Centre hospitalier de l’Université de Montréal. Clinical and biochemical data were collected, including lipid profiles before and during the first year of treatment with mitotane.

Results
Among the 45 studied patients, 26 (58%) had a complete lipid profile before the introduction of mitotane and at least 1 lipid profile during the first year of treatment, and 19 patients (42%) had a lipid profile following initiation of the treatment. Among the 26 patients who had lipid profiles before and after the introduction of mitotane, the increase of LDL-c was 2.19 mmol/L (76%) (P< 0.0001), HDL-c was 0.54 mmol/L (35%) (P= 0.0002), Tg was 1.80 mmol/L (129%) (P< 0.0001) and non-HDL-c was 2.73 mmol/L (79%) (P< 0.0001). Between the first and the sixth month of mitotane treatment, peak values (n  = 45) of LDL-c and non-HDL-c were reached in 42 patients (93%) and 37 patients (82%), respectively, whereas peak values of HDL-c were reached after 6 months of mitotane treatment in 29 patients (66%). The peak value of Tg was almost equal throughout the first year. The mean peak values of HDL-c, Tg and non-HDL-c showed significant associations with their respective mitotane concentrations (β = 0.352, P= 0.03; β = 0.406, P= 0.02 and β = 0.339, P= 0.05).

Conclusion
The introduction of mitotane produces a clinically significant elevation of lipid parameters (LDL-c, HDL-c, Tg and non-HDL-c) during the first year of treatment.
Initiation of Opioid Prescription and Risk of Suicidal Behavior Among Youth and Young Adults
Authors: Fine Kimberly L. , Rickert Martin E. , O’Reilly Lauren M. , Sujan Ayesha C. , Boersma Katja , Chang Zheng , Franck Johan , Lichtenstein Paul , Larsson Henrik , D’Onofrio Brian M. , Quinn Patrick D. 
Published: February 2022

BACKGROUND AND OBJECTIVES
Opioids are involved in an increasing proportion of suicide deaths. This study examined the association between opioid analgesic prescription initiation and suicidal behavior among young people.

METHODS
We analyzed Swedish population-register data on 1 895 984 individuals ages 9 to 29 years without prior recorded opioid prescriptions. We identified prescriptions dispensed from January 2007 onward and diagnosed self-injurious behavior and death by suicide through December 2013. We first compared initiators with demographically matched noninitiators. To account for confounding, we applied an active comparator design, which examined suicidal behavior among opioid initiators relative to prescription nonsteroidal antiinflammatory drug (NSAID) initiators while inverse-probability-of-treatment weighting with individual and familial covariates.

RESULTS
Among the cohort, 201 433 individuals initiated opioid prescription. Relative to demographically matched noninitiators, initiators (N = 180 808) had more than doubled risk of incident suicidal behavior (hazard ratio = 2.64; 95% confidence interval [CI], 2.47–2.81). However, in the active comparator design, opioid initiators (N = 86 635) had only 19% relatively greater risk of suicidal behavior compared with NSAID initiators (N = 255 096; hazard ratio = 1.19; 95% CI,: 1.11–1.28), corresponding to a weighted 5-year cumulative incidence of 2.2% (95% CI, 2.1–2.4) for opioid and 1.9% (95% CI, 1.9–2.0) for NSAID initiators. Most sensitivity analyses produced comparable results.

CONCLUSIONS
Opioid initiation may make only a small contribution to the elevated risk of suicidal behavior among young people receiving pharmacologic pain management. In weighing benefits and harms of opioid initiation, our results suggest that increased risk of suicidal behavior may not be a major concern.
New bacteria genera associated with rice (Oryza sativa L.) in Cuba promote the crop growth
Authors: Hernández-Forte Ionel , Pérez-Pérez Reneé , Taulé-Gregorio Cecilia Beatríz , Fabiano-González Elena , Battistoni-Urrutia Federico , Nápoles-García Maria Caridad 
Published: February 2022

Introduction. The rice cultivar INCA LP-7 is one of the eleven principal cultivars in Cuba due to their high yield potential, salinity tolerance, and pathogens resistance. However, there are not reports about the isolation, identification, and characterization of bacteria associated to this cultivar that promote its growth. Objective. To select promising bacteria from the rhizosphere of the INCA LP-7 rice cultivar to promote the crop growth. Materials and methods. The investigation was carried out in 2015 and 2016 at the Instituto Nacional de Ciencias Agropecuarias, Cuba and Instituto de Investigaciones Biologicas Clemente Estable, Uruguay. The 16SrNA gene of bacteria associated with the INCA LP-7 rice cultivar was isolated and identified by sequencing. Characterization was performed as plant growth promoting bacteria and the effect of bacterial inoculation on rice growth was studied. Results. Eleven rizopheric bacteria were isolated from rice plants of the INCA LP-7cultivar. A phylogenetic analysis showed that for the first time in Cuba Pantoea, Acinetobacter, and Mitsuaria genera were reported associated with rice. Rhizobium and Enterobacter genera were also informed as rhizospheric bacteria of INCA LP-7 rice cultivar. Some isolates solubilize inorganic phosphates and potassium, produce siderophores and indolic compound, had exo-celulase and protease activity and formed biofilm. The inoculation of isolates belonging to Pantoea genus produced an increase in height, root length, and biomass of rice plants under greenhouse conditions. Conclusions. Pantoea sp. GG1 and Pantoea sp. GG2 were the most promising strains for the inoculation of the INCA LP-7 rice cultivar. This is the first report in Cuba that focuses on the characterization of the bacterial microbiota part associated to Cuban rice cultivar INCA LP-7 and reports bacteria of the Pantoea genus as crop growth promoters.
The effect of black rot on grape berry composition
Authors: Kellner N. , Antal E. , Szabó A. , Matolcsi R. 
Published: February 2022

AbstractGuignardia bidwellii, indigenous to North America, is a significant pathogen of grapes long known in Hungary, infecting only the growing green parts of the vine (leaves, petioles, shoots, and bunches). In the absence of adequate plant protection and extreme weather conditions such as a predominantly humid, warm year, black rot of grapes can be expected. The pathogen can cause high yield losses due to grape rot and reduce wine quality if the infection is severe.The evolution of certain biogenic amine compounds were investigated under the influence of grape black rot. The results obtained showed that they were present in low concentrations from an oenological point of view. Polyphenol composition was consistent with the literature, blackening affected mainly the concentration of catechin. Black rot fungus does not produce β-glucosidase enzyme. In terms of resveratrol content, black rot has no particular effect. However, likeBotrytis cinerea, it produces glycerol and, proportionally, gluconic acid in lower concentrations.It can be concluded that black rot of grapes does not cause health problems when introduced into wine processing.
Hallazgos clínicos, epidemiológicos y virológicos del primer brote de COVID-19 en Medellín, Antioquia, Colombia
Authors: Velásquez Cuadros Carlos Hernando , Almanza Payares Rita Elena , Silva López Yury Johana 
Published: February 2022

Objetivo: Caracterizar clínica, epidemiológica y virológicamente el primer brote de covid-19, a partir del caso primario en Medellín (Colombia), a través de las acciones de vigilancia y control epidemiológico realizadas para su contención.
Metodología: Estudio descriptivo retrospectivo. Los casos secundarios se identificaron teniendo en cuenta la definición del protocolo del Instituto Nacional de Salud. La recolección de datos fue obtenida del Sistema de Vigilancia en Salud Pública, la investigación epidemiológica de campo, historia clínica y resultados de laboratorio. Se tuvieron en cuenta patrones clínicos de la enfermedad (signos y síntomas), componentes epidemiológicos (acciones de vigilancia y control de la transmisión) y virológicos (con el uso de la prueba diagnóstica para sars-CoV-2 y la evaluación de la recuperación virológica). La confirmación de los casos se hizo por técnica de detección diagnóstica de coronavirus Wuhan 2019 por Reverse Transcription Polymerase Chain Reaction - Real Time, protocolo Charité, Berlín, Alemania 2020, procesadas en e informadas por el Laboratorio Nacional de Referencia del Instituto Nacional de Salud.
Resultados: El caso primario de Medellín ingresó al país el 2 de marzo de 2020, procedente de Madrid (España) y fue confirmado el 9 de marzo. Se identificaron 52 contactos estrechos en 9 conglomerados. Las acciones de vigilancia en salud pública permitieron identificar 5 casos relacionados en una fase temprana de la enfermedad.
Conclusiones: La caracterización del caso primario en Medellín permitió identificar el primer brote de covid-19 y orientar las medidas de control epidemiológico, como aislamientos, tomas de muestras, seguimiento a contactos y búsquedas de casos secundarios.
Periodontal disease and genetics an overview and lineage
Authors: Sebastian Sajith , Susan Jenny 
Published: February 2022

Periodontal diseases are a heterogeneous group of pathologies. It is believed that bacteria are required to develop periodontitis. While microbial and other environmental factors initiate and modulate periodontal disease, individuals respond differently to common environmental challenges, and this differential response is influenced by the individual’s genetic profile. Genes clearly play a role in the predisposition to and progression of periodontal diseases. Susceptibility to periodontal disease and the severity of the disease results from the interactions of genetic mutations and polymorphisms. This is my brief review of various genetic factors and methods used to delineate the various periodontal diseases and genetic associations.Their affects on the disease phenotype, morphology and outcome.Periodontitis is clearly multifactorial, and researchers need to design studies that examine the role of important environmental and genetic factors simultaneously. Given the large no. of genes in human genome and bacteria in the oral cavity, it is likely that genes and environment interact in important but as-yet un-recognized ways to alter disease risk. Most importantly, identifying specific genetic risk factors may be academically appealing but is of little use unless it leads to improvements in the prevention or treatment of disease.
Management and visual outcome in patients of phacolytic glaucoma at a tertiary eye care hospital
Authors: Singasandra Sanjana Marijogaiah , Nannaware Shital Laxman , Mallaiah Dakshayini , Venkataswamy Shwetha  Bennavara 
Published: February 2022

Phacolytic glaucoma is one of the commonest cause of secondary glaucoma due to senile cataracts. This study was conducted to evaluate the visual outcome of phacolytic glaucoma. 1. To study the management of phacolytic glaucoma; 2. To study the visual outcome after planned manual SICS. Participants were 30 patients in a tertiary eye care hospital for both urban and rural population diagnosed as phacolytic glaucoma. Demographic data, duration of the symptoms, IOP of the patients before presenting to the hospital were noted. Patient underwent Manual SICS with PCIOL implantation after the control of intraocular pressure and inflammation. The data was analyzed by simple statistical methods. Mean age of the patients was 61.63 yrs. Female to male ratio was 1.8:1. Duration of the presenting symptoms before reporting to the hospital was &#60;1 week in 16 (53%), 1-2 week in 11 (37%) and &#62;2 week in 3 (10%). Mean IOP was 40.7mmHg preoperatively. Visual Acuity was perception of light in 16 (53.33%) and hand movements in 14 (46.66%) preoperatively. Postoperative visual acuity at 6 weeks was 6/6-6/12 in 19(63.33),6/18-6/60 in 8 (27%), &#60;6/60 in 3 (10). Following surgery 28 of 30 eyes (93.33%) had IOP less than 21 mmHg at discharge. Fellow eye showed pseudophakia in 18 (60%), immature cataract in 12 (40%). Cataract surgery proves to be effective in lowering the intraocular pressure and visual recovery in phacolytic glaucoma.
Clinical study and management of various ocular manifestations in hypertensive patients at tertiary eye care centre in South India
Authors: Sultana Aliya 
Published: February 2022

Aim of our study is to study the various ocular manifestations and management in hypertensive patients. This was retrospective interventional study conducted over a period of 5 years from January 2016 to December 2020.All patients of all age group having primary and secondary hypertension, referred from physicians for screening were included. Patients with associated diabetes mellitus were excluded.421 patients who presented to our retina clinic underwent detail ocular and systemic examination. BCVA, slit lamp examination, fundus examination, B scan, OCT, FFA and documentation done in all cases. Patients presented with various ocular manifestations were managed based on the clinical status. Consent was taken for the management. Patients with ischemic retina showed poor outcome, patients with early presentation showed good outcome. Hypertension is one comorbidity which is responsible for eye problems, need frequent screening, fundus examination is non-invasive procedure which helps in detecting the vascular changes early.
Mujeres y activistas: construyendo vejeces en narrativas patchwork
Authors: Mazzucchelli Nicole , Reyes Espejo María Isabel 
Published: February 2022

Los discursos sobre el envejecimiento de las mujeres mayores se han centrado en las problemáticas y dificultades que estas enfrentan, omitiendo el reconocimiento de sus recursos y potencialidades. Esta investigación tiene por objeto rescatar los significados de envejecer de mujeres activistas de la Agrupación Bordadoras por la Memoria, en Chile. Desde la gerontología feminista y la perspectiva narrativa, producimos narrativas patchwork que ofrecen nuevas versiones de ser mayor. Los resultados muestran la emergencia de narrativas sobre la vejez en pandemia, las distinciones de género, la sabi- duría adquirida en esta etapa, y su experiencia de envejecer desde la acción política, cuestionando las características con las que se describe tradicionalmente a las mujeres viejas. Se concluye que el ejercicio de construcción y cuestionamiento que las participantes realizan frente a su propia vejez desde su experiencia asociativa les permite tensionar y disputar posiciones, transgrediendo la repre- sentación normativa de la vejez hegemónica.
¿Qué es la cultura frente a la historia? Glosas sobre los trabajos de Jürgen Golte
Authors: Diez Alejandro 
Published: February 2022

Tuve la fortuna de conocer a Jürgen Golte a lo largo de más de un cuarto de siglo. Como estudiante de antropología, como joven egresado, como profesor o como simple colega, pude interactuar con él en conferencias, congresos, seminarios, coloquios académicos en la Universidad Católica, en San Marcos, en el IEP o en Clacso. Recuerdo claramente la primera vez que lo vi comentar la presentación de un conocido académico en un evento del IEP hace más de treinta años: mientras asimilaba sus demoledoras críticas, agradecía mentalmente que no hubiera leído mi trabajo. Crítico agudo y habitualmente acertado era Jürgen. Por supuesto, no siempre tuve la misma suerte. En cualquier caso, se puede decir con total certeza que siempre era muy interesante escucharlo, tanto en sus presentaciones como en sus comentarios académicos y sus conversaciones casuales. También es muy interesante leerlo. Ha dejado un largo legado de trabajos de investigación a lo largo de más de cinco décadas, desde sus primeros trabajos históricos sobre los Andes hasta los últimos sobre la iconografía moche, y seguramente tenía aún varios otros textos en camino, por lo menos alguno sobre la iconografía de Tiahuanaco-Wari, anunciado por él mismo. Propongo en este artículo una breve guía de lectura y un recorrido por algunos de sus principales estudios. Sin ser exhaustivo —sino más bien intencionalmente selectivo— procuro un recorrido analítico sobre los que considero sus principales aportes al conocimiento de las realidades peruanas y al desarrollo de la antropología en el Perú. Revisar y reseñar los trabajos de Jürgen Golte no es una tarea sencilla. No solo por lo abundante de su bibliografía, sino por la forma como ha ido distribuyendo y decantando ideas, conceptos, intuiciones y certezas en distintos trabajos a lo largo del tiempo; reiterando algunas ideas en distintos textos. Proporcionando claves distintas y originales, sus estudios nos enseñan tanto sobre la realidad «antropológica» peruana como sobre métodos y postulados para el análisis.
The effect of game technology on the development of preschool children with speech disorders
Authors: Ibatova Gaukhar , Makhmetova Aigerim , Zhoraeyeva Saule Basarbaevna , Amiresheva Bibinur , Tinibekovna Nyshanova  Saltanat , Satova Akmaral 
Published: February 2022

The purpose of the article was to analyze the psychological and pedagogical conditions of word-formation skills for Kazakh-speaking preschool children with speech disorders on the basis of learning theories and contemporary approaches. To achieve the set aim, we have studied psychophysiological peculiarities of preschool children with speech disorder. We have allocated the most significant learning theories and approaches, which promote the assimilation of word-formation. We have come to understand that the indicators of speech development of many modern Kazakh-speaking preschoolers do not correspond to the age norm, which is influenced by word-formation operations. For Kazakh-speaking preschool children with speech disorders it is rather difficult to distinguish elementary forms as the original word, consisting of a stem and a derivative by including diminutive-affectionate suffixes. The driving forces of word-formation development of Kazakh-speaking preschoolers with speech disorders are contradictions that arise in connection with the development of a number of its needs. It should be pointed out that game technology is considered as the most powerful pedagogical condition in the development of Kazakh-speaking preschool children with speech disorders.
Keywords: Kazakh-speaking preschool children, psychological and pedagogical conditions, learning theories, approaches, word-formation, speech games
Impact of ICT integration on the development of vocational high school teacher TPACK in the digital age 4.0.
Authors: Istiningsih Istiningsih 
Published: February 2022

To investigate the impact of the integration of information and communication technology (ICT) on the development of the Technological Pedagogical Content Knowledge (TPACK) framework for Vocational High School teachers in the Digital Era 4.0, this research will look at the integration of ICT. The evaluation of the Online Learning Implementation Plan (RPP) of the Computer and Network Engineering Department in the even semester of the 2020/2021 academic year revealed the impact of ICT on instructors' TPACK. The research design that was used was a qualitative case study. The study included 20 teacher participants from Private Vocational Schools who were majoring in Computer and Network Engineering in order to explore the influence of ICT adoption on their classrooms. Findings from this study reveal that integrating ICT into the TPACK framework, as measured by this research project, has a positive impact on teachers. Teachers are capable of resolving issues that arise during online learning activities and providing learning assessment values that are appropriate for their students' skills and learning performance. Schools must provide more effective and professionally targeted ICT support and training in order to improve teacher competence in order to educate vocational students for a digital future, as a result of these consequences. Considering the demands for the integration of ICT into the design of educational curricula in order to develop the TPACK abilities of teachers in the face of the digital revolution is something that the government can consider.
Keywords: vocational, ICT, TPACK, secondary school, engineering, educational curricula.
Formation of a spiritual worldview in students of art education specialties with the help of ethno-design technology
Authors: Alzhanov Gadilbek , Smanova Akmaral , Zor Aydin , Rabilova Zoya , Ryssymbetov Yerzhan , Karabalin Urazbay 
Published: February 2022

The aim of this study is to evaluate student views on the creation of spiritual well-being of art education residency students with the help of ethno-design technology. This research was designed in accordance with the qualitative research method. In order to collect data in the research, a semi-structured interview form was prepared by the researchers. The study group of the research consists of 20 graduate students studying in the field of art education at various universities in Kazakhstan in the 2021–2022 academic year. In the research, it was concluded that art education residency students frequently use ethno-design technologies in art education and find ethno-design technologies important in terms of art education. In addition, as a result of the research, it was observed that the art education residency students were undecided about their spiritual well-being and the majority of the students stated that ethno-design technology had a positive effect on their spiritual well-being. In order to popularise the use of ethno-design technologies by art education specialisation students, the education curricula should be enriched and seminars should be organised to increase the spiritual well-being of students.
Keywords: Ethno-design technology, art education, spiritual well-being, students of art education specialties