bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spinel Harzburgite-Derived Silicate Melts Forming Sulfide-Bearing Orthopyroxenite in the Lithosphere. Part 1: Partition Coefficients and Volatile Evolution Accompanying Fluid- and Redox-Induced Sulfide Formation
Authors: Bénard A. , Le Losq C. , Müntener O. , Robyr M. , Nebel O. , Arculus R. J. , Ionov D. A. 
Published: July 2022

We report abundances of major trace and volatile elements in an orthopyroxenite vein cutting a sub-arc, mantle-derived, spinel harzburgite xenolith from Kamchatka. The orthopyroxenite contains abundant sulfides and is characterized by the presence of glass (formerly melt) both interstitially and as inclusions in minerals, comparable with similar veins from the West Bismarck arc. The glass formed by quenching of residual melts following crystallization of abundant orthopyroxene, amphibole, and minor olivine and spinel. The interstitial glass has a low-Ti, high-Mg# andesite composition, with a wide range of H2O and S contents but more limited F and Cl variations. We calculate trace element partition coefficients using mineral and glass data, including those for halogens in amphibole, which agree with experimental results from the literature. Despite having a similar, high-Mg# andesite composition, the orthopyroxene-hosted glass inclusions usually contain much more H2O and S than the interstitial glass (4–7 wt% and ∼2,600 ppm, respectively). The initial vein-forming melts were oxidized, recording oxygen fugacity conditions up to ∼1.5 log units above the fayalite–magnetite–quartz oxygen buffer. They intruded the sub-arc mantle lithosphere at ≥1,300°C, where they partially crystallized to form high-Mg# andesitic derivative melts at ca. 1,050–1,100°C. Comparison with literature data on glass-free orthopyroxenite veins from Kamchatka and the glass-bearing ones from West Bismarck reveals fundamental similarities indicating common parental melts, which were originally produced by low-degree melting (≤5%) of spinel harzburgite at ≥1,360°C and ≤1.5 GPa. This harzburgite source likely contained ≤0.05 wt% H2O and a few ppm of halogens. Volatile evolution inferred from glass compositions shows that (i) redox exchange between S6+ in the original melt and Fe2+ in the host mantle minerals, together with (ii) the formation of an S-bearing, (H2O, Cl)-rich hydrothermal fluid from the original melt, provides the conditions for the formation of abundant sulfides in the orthopyroxenites during cooling. During this process, up to 85% of the original melt S content (∼2,600 ppm) is locally precipitated as magmatic and hydrothermal sulfides. As such, melts derived from spinel harzburgite sources can concentrate chalcophile and highly siderophile metals in orthopyroxenite dykes and sills in the lithosphere.
Experimental Study on Damage Properties of Granites Under Flowing Acid Solution
Authors: Chen Wei , Wan Wen , Zhao Yanlin , Wu Qiuhong , He Huan , Peng Wenqing , Wu Xiaofan , Zhou Yu , Wu Li , Xie Senlin 
Published: July 2022

In order to study the deterioration characteristics of the tunnel surrounding rock under the scouring of flowing groundwater, we ratioed similar acidic solutions based on groundwater composition. The microstructure of granite samples cored on site, deformation features, and evolution characteristics of mechanical parameters under saturations with different flow rates and various pH values were analyzed using scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), nuclear magnetic resonance (NMR), and X-ray diffraction (XRD). The results indicate the following: 1) compared with the static water condition, the higher flow rate produces greater relative changes in granite’s microstructure, porosity, mass, and pH of the immersed solution. Moreover, the rate of change is relatively fast in the early stage and gradually slows down until it reaches a stable state. 2) Compared with the natural dry condition, the solution with a lower pH value causes the structural framework of the specimen to loosen, the mass loss degree to increase, and the porosity dispersion to intensify. 3) The dynamic water is more sensitive than the static water to the elastic vertical wave velocity of granite. Compared with the dry sample, the elastic longitudinal wave velocity of the sample in acidic solution with pH = 2 and flow rates of 0, 150, and 300 mm·s−1 for 49 days decreased by 8.7, 10.9, and 13.5%, respectively, which accelerates the instability and failure of the granite surroundings.
Integrated Geophysical Assessment of Groundwater Potential in Southwestern Saudi Arabia
Authors: Mohamed Ahmed , Al Deep Mohamed , Othman Abdullah , Taha Ayman I. , Alshehri Fahad , Abdelrady Ahmed 
Published: July 2022

Saudi Arabia is seeking fresh groundwater resources to face the increase in anthropogenic activities. The groundwater storage variations and occurrence were investigated and the surface and subsurface structures influencing the groundwater resources in the research area were defined using a combined study of Gravity Recovery and Climate Experiment, aeromagnetic data, and electrical resistivity data with other relevant datasets. Results are: The groundwater storage fluctuation is calculated at −0.34 ± 0.01 mm/yr during the period 04/2002-12/2021. The area is receiving an average annual rainfall rate of 117.6 mm during the period 2002 to 2019. Three structural trends, defined in the directions of NS, NNW, and NNE are cutting the sedimentary cover and the basement rocks. The sedimentary cover ranges from 0 to 1.2 km thick. Vertical electrical sounding results indicate three main geoelectric layers: the surface geoelectrical layer of higher resistivity values (428-9626 Ω. m) is made up of unconsolidated Quaternary sediments; the water-bearing layer of saturated sands with a resistivity range between 5.1 and 153 Ω. m and with depths vary from 1 to 94 m, and highly fractured basement rocks with resistivity values ranging from 813 to 6030 Ω. m. The integrated results are useful in providing a comprehensive image of the study area’s surface and subsurface structures, as well as groundwater potential in the southwestern part of Saudi Arabia. Our integrated approach provides a reproducible model for assessing groundwater potential in arid and semiarid areas.
Global Research Trends on Infertility and Psychology From the Past Two Decades: A Bibliometric and Visualized Study
Authors: Zhu Hongkun , Shi Lingli , Wang Rong , Cui Lijuan , Wang Jiahui , Tang Mengyu , Qian Haiqing , Wei Minggang , Wang Lihong , Zhou Huifang , Xu Wenting 
Published: July 2022

ObjectivesThe aim of this study was to evaluate the global scientific output of research on infertility and psychology; explore the current status and trends in this field through the cooperation of authors, countries, and institutions; shed light on the direction of clinical infertility research in the future, and provide inspiration for targeted diagnosis and treatment of infertility.MethodsResearch publications on infertility and psychology from the past two decades were retrieved from the Web of Science Core Collection (WoSCC). Bibliometric analyses were performed using VOSviewer software and the bibliometrix R package. Network maps were generated to evaluate the collaborations between different authors, countries, institutions, and keywords.ResultsA total of 151 articles related to the study of infertility and psychology were identified. We observed a gradual increase in the number of publications from 2001 to 2021, and the trend has been relatively stable in the past eight years. Human Reproduction (England), as the leading journal publishing the most papers (29 articles), was cited in the most journals (1208 times). Boivin J was the most prolific author (16 articles), with the largest number of citations (890 times) and the highest h-index (14) during the past decades. Boivin J was also the leader with the highest publication frequency and more active cooperation with other top authors. The United Kingdom (34 papers) and Cardiff University (25 articles) contributed the most publications and were the leading contributors in this field. Active cooperation between countries and between institutions was observed, and analyses of articles and references were also shown. The main hot topics included matters related to women (39 times), in-vitro salt (31 times), infertility (30 times), couples (25 times), and impact (24 times).ConclusionOur study results provide a comprehensive overview of the development of scientific literature, allowing relevant authors and research teams to recognize the current research status in this field. At the same time, infertility and psychology may soon become hotspots and should be closely monitored.
Predicting the Risk of Diabetic Foot Ulcers From Diabetics With Dysmetabolism: A Retrospective Clinical Trial
Authors: Jiang Mingyang , Gan Fu , Gan Meishe , Deng Huachu , Chen Xuxu , Yuan Xintao , Huang Danyi , Liu Siyi , Qin Baoyu , Wei Yanhong , Su Shanggui , Bo Zhandong 
Published: July 2022

BackgroundDiabetic foot ulcer (DFU) in patients with type 2 diabetes mellitus (T2D) often leads to amputation. Early intervention to prevent DFU is urgently necessary. So far, there have been no studies on predictive models associated with DFU risk factors. Our study aimed to quantify the predictive risk value of DFU, promote health education, and further develop behavioral interventions to reduce the incidence of DFU.MethodsData from 973 consecutive patients with T2D was collected from two hospitals. Patients from the Guangxi Medical University First Affiliated Hospital formed the training cohort (n = 853), and those from the Wuming Hospital of Guangxi Medical University formed the validation cohort (n = 120). Independent variable grouping analysis and multivariate logistic regression analysis were used to determine the risk factors of DFUs. The prediction model was established according to the related risk factors. In addition, the accuracy of the model was evaluated by specificity, sensitivity, predictive value, and predictive likelihood ratio.ResultsIn total, 369 of the 853 patients (43.3%) and 60 of the 120 (50.0%) were diagnosed with DFUs in the two hospitals. The factors associated with DFU were old age, male gender, lower body mass index (BMI), longer duration of diabetes, history of foot disease, cardiac insufficiency, no use of oral hypoglycemic agent (OHA), high white blood cell count, high platelet count, low hemoglobin level, low lymphocyte absolute value, and high postprandial blood glucose. After incorporating these 12 factors, the nomogram drawn achieved good concordance indexes of 0.89 [95% confidence interval (CI): 0.87 to 0.91] in the training cohort and 0.84 (95% CI: 0.77 to 0.91) in the validation cohort in predicting DFUs and had well-fitted calibration curves. Patients who had a nomogram score of ≥180 were considered to have a low risk of DFU, whereas those having ≥180 were at high risk.ConclusionsA nomogram was constructed by combining 12 identified risk factors of DFU. These 12 risk factors are easily available in hospitalized patients, so the prediction of DFU in hospitalized patients with T2D has potential clinical significance. The model provides a reliable prediction of the risk of DFU in patients with T2D.
Effects of Exercise Intervention on Type 2 Diabetes Patients With Abdominal Obesity and Low Thigh Circumference (EXTEND): Study Protocol for a Randomized Controlled Trial
Authors: Liu Dan , Zhang Ying , Wu Liang , Guo Jingyi , Yu Xiangtian , Yao Huasheng , Han Rui , Ma Tianshu , Zheng Yuchan , Gao Qiongmei , Fang Qichen , Zhao Yan , Zhao Yanan , Sun Biao , Jia Weiping , Li Huating 
Published: July 2022

IntroductionType 2 diabetes patients have abdominal obesity and low thigh circumference. Previous studies have mainly focused on the role of exercise in reducing body weight and fat mass, improving glucose and lipid metabolism, with a lack of evaluation on the loss of muscle mass, diabetes complications, energy metabolism, and brain health. Moreover, whether the potential physiological benefit of exercise for diabetes mellitus is related to the modulation of the microbiota-gut-brain axis remains unclear. Multi-omics approaches and multidimensional evaluations may help systematically and comprehensively correlate physical exercise and the metabolic benefits.Methods and AnalysisThis study is a randomized controlled clinical trial. A total of 100 sedentary patients with type 2 diabetes will be allocated to either an exercise or a control group in a 1:1 ratio. Participants in the exercise group will receive a 16-week combined aerobic and resistance exercise training, while those in the control group will maintain their sedentary lifestyle unchanged. Additionally, all participants will receive a diet administration to control the confounding effects of diet. The primary outcome will be the change in body fat mass measured using bioelectrical impedance analysis. The secondary outcomes will include body fat mass change rate (%), and changes in anthropometric indicators (body weight, waist, hip, and thigh circumference), clinical biochemical indicators (glycated hemoglobin, blood glucose, insulin sensitivity, blood lipid, liver enzyme, and renal function), brain health (appetite, mood, and cognitive function), immunologic function, metagenomics, metabolomics, energy expenditure, cardiopulmonary fitness, exercise-related indicators, fatty liver, cytokines (fibroblast growth factor 21, fibroblast growth factor 19, adiponectin, fatty acid-binding protein 4, and lipocalin 2), vascular endothelial function, autonomic nervous function, and glucose fluctuation.DiscussionThis study will evaluate the effect of a 16-week combined aerobic and resistance exercise regimen on patients with diabetes. The results will provide a comprehensive evaluation of the physiological effects of exercise, and reveal the role of the microbiota-gut-brain axis in exercise-induced metabolic benefits to diabetes.Clinical Trial Registrationhttp://www.chictr.org.cn/searchproj.aspx, identifier ChiCTR2100046148.
Cancer Risk in Hashimoto’s Thyroiditis: a Systematic Review and Meta-Analysis
Authors: Hu Xiaojie , Wang Xuanyu , Liang Yue , Chen Xin , Zhou Siyuan , Fei Wenting , Yang Yuxin , Que Huafa 
Published: July 2022

ObjectiveResearch data suggest that patients with Hashimoto’s thyroiditis may increase the risk of cancer. However, existing research is inconsistent with this view. Therefore, to investigate the effect of Hashimoto’s thyroiditis on the risk of developing cancer, we conducted this study.MethodsWe searched the PubMed and Embase databases from database establishment until March 2022. After rigorous literature screening by two authors, 23 studies that met the inclusion criteria were identified, and the required data were independently extracted.ResultsWe retrieved 3591 records, and after the screening, 11 case-control studies and 12 cohort studies were included in the analysis. Data analysis suggested that patients with Hashimoto’s thyroiditis had an increased risk of developing breast cancer, urogenital cancer, digestive organs cancer, hematologic cancer, and a low risk of respiratory cancers.ConclusionsThis systematic review and meta-analysis showed that patients with HT may have a significantly increased risk of thyroid cancer, breast cancers, lung cancer, digestive system cancer, urogenital cancers, blood cancers, and prolactinoma people without HT.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD 42022320741.
Effect of Exercise Instructions With Ambulatory Accelerometer in Japanese Patients With Type 2 Diabetes: a Randomized Control Trial
Authors: Matsushita Jin , Okada Hiroshi , Okada Yuki , Sekiyama Takashi , Iida Hideto , Shindo Atsushi , Murata Hiroaki , Fukui Michiaki 
Published: July 2022

This study aimed to investigate the effects of physical therapists’ exercise instructions in Japanese patients with type 2 diabetes. Thirty-six participants were recruited from the outpatient clinic at Matsushita Memorial Hospital, Osaka, Japan from June 2020 to September 2020 and were randomly assigned to either the non-intervention or intervention group. The intervention group received exercise instructions from physical therapists for 30 min at baseline (week 0) and at week 4 by referring to ambulatory accelerometer records. Laboratory parameters, physical activity, body composition, motor skill, and transtheoretical model were assessed in both the groups at baseline (week 0) and week 8. In week 8, patients in the intervention group had a statistically significant reduction in HbA1c levels compared with those in the non-intervention group (7.3% [6.8-%–7.9%] vs. 7.4% [7.3%–7.7%], P = 0.04). The number of steps per day (P = 0.001), energy expenditure (P = 0.01), lower extremity muscle strength (P = 0.002), and 6-min walk test results (P = 0.04) were significantly increased in the intervention group compared with those in the non-intervention group in week 8. The transtheoretical model varied between baseline (week 0) and week 8 only in the intervention group (P &lt; 0.001). Thus, outpatient exercise instructions from physical therapists could improve glycemic control owing to physical activity by improving motor skills and changing the transtheoretical model in Japanese patients with type 2 diabetes.
The Land–Water–Energy Nexus of Ruzizi River Dams (Lake Kivu Outflow, African Great Lakes Region): Status, Challenges, and Perspectives
Authors: Muvundja Fabrice Amisi , Walumona Jacques Riziki , Dusabe Marie-Claire , Alunga Georges Lufungula , Kankonda Alidor Busanga , Albrecht Christian , Eisenberg Joachim , Wüest Alfred 
Published: July 2022

Hydroelectric power (HP) represents the main source of electricity in Africa, including the Democratic Republic of Congo. The demand for new dam construction is high, and major projects are currently progressing through planning and implementation stages. New HP dams should comply with both past and emerging environmental requirements. River systems need water to maintain hydraulic and ecological functions. Flow regime disturbance can prevent rivers from providing their ecosystem services and disrupt riparian communities. Most dammed rivers in Africa are understudied, however, in terms of their environmental flow requirements. This study analysed the hydrological regime and water quality of the Ruzizi River. The research investigated conditions of minimum water flow and hydropeaking at the Ruzizi I HP dam in terms of land management constraints and ecological impacts. According to Gumbel’s hydrological model, a discharge of ∼130 m3/s showed the longest return period (12 years) among the most recurrent flows. By contrast, the maximum recorded discharge of 143 m3/s showed a return time of 76 years. Any discharge between 46 and 120 m3/s could occur at any time within three years. The discharge–hydropower production relationship for the power plant provided a possible minimum environmental flow of 28 m3/s (i.e., 25%). Drinking water quality was assessed according to WHO water quality index (WQI) standards. Turbidity (i.e., total suspended solids) upstream and downstream of dams correlated strongly with rainfall (r = 0.8; n = 12) and land use. WQI values observed in excess of WHO drinking water standards indicate that the Ruzizi River is currently unsuitable for drinking water purposes.
Association Between Telomere Length and Skin Cancer and Aging: A Mendelian Randomization Analysis
Authors: Son Nannan , Cui Yankun , Xi Wang 
Published: July 2022

Background: Telomere shortening is a hallmark of cellular senescence. However, telomere length (TL)-related cellular senescence has varying effects in different cancers, resulting in a paradoxical relationship between senescence and cancer. Therefore, we used observational epidemiological studies to investigate the association between TL and skin cancer and aging, and to explore whether such a paradoxical relationship exists in skin tissue.Methods: This study employed two-sample Mendelian randomization (MR) to analyze the causal relationship between TL and skin cancer [melanoma and non-melanoma skin cancers (NMSCs)] and aging. We studied single nucleotide polymorphisms (SNPs) obtained from pooled data belonging to genome-wide association studies (GWAS) in the literature and biobanks. Quality control was performed using pleiotropy, heterogeneity, and sensitivity analyses.Results: We used five algorithms to analyze the causal relationship between TL and skin aging, melanoma, and NMSCs, and obtained consistent results. TL shortening reduced NMSC and melanoma susceptibility risk with specific odds ratios (ORs) of 1.0344 [95% confidence interval (CI): 1.0168–1.0524, p = 0.01] and 1.0127 (95% CI: 1.0046–1.0209, p = 6.36E-07), respectively. Conversely, TL shortening was validated to increase the odds of skin aging (OR = 0.96, 95% CI: 0.9332–0.9956, p = 0.03). Moreover, the MR-Egger, maximum likelihood, and inverse variance weighted (IVW) methods found significant heterogeneity among instrumental variable (IV) estimates (identified as MR-Egger skin aging Q = 76.72, p = 1.36E-04; melanoma Q = 97.10, p = 1.62E-07; NMSCsQ = 82.02, p = 1.90E-05). The leave-one-out analysis also showed that the SNP sensitivity was robust to each result.Conclusion: This study found that TL shortening may promote skin aging development and reduce the risk of cutaneous melanoma and NMSCs. The results provide a reference for future research on the causal relationship between skin aging and cancer in clinical practice.
Early Discovery of Children With Lysosomal Acid Lipase Deficiency With the Universal Familial Hypercholesterolemia Screening Program
Authors: Sustar Ursa , Groselj Urh , Trebusak Podkrajsek Katarina , Mlinaric Matej , Kovac Jernej , Thaler Martin , Drole Torkar Ana , Skarlovnik Ajda , Battelino Tadej , Hovnik Tinka 
Published: July 2022

Lysosomal acid lipase deficiency (LAL-D) is an autosomal recessive lysosomal storage disorder, caused by homozygous or compound heterozygous pathogenic variants in the LIPA gene. Clinically, LAL-D is under- and misdiagnosed, due to similar clinical and laboratory findings with other cholesterol or liver misfunctions. As a part of the Slovenian universal familial hypercholesterolemia (FH) screening, LAL-D is screened as a secondary condition among other rare dyslipidemias manifesting with hypercholesterolemia. Out of 669 children included, three were positive for a homozygous disease-causing splicing variant NM_000235.4: c.894G &gt; A (NP_000226.2:p. Gln298Gln) in the LIPA gene (NG_008194.1). The mean age by the diagnosis of LAL-D was 9.8 ± 0.9 years. Moreover, all three LAL-D-positive children had an important elevation of transaminases and decreased activity of the lysosomal acid lipase enzyme. Abdominal MRI in all children detected an enlarged liver but a normal-sized spleen. In conclusion, universal FH screening algorithms with the confirmatory genetic analysis in the pediatric population enable also rare dyslipidemia detection at an early age. An important clinical criterion for differentiation between FH and the LAL-D-positive children has elevated transaminase levels (AST and ALT). In all three LAL-D positive children, an improvement in cholesterol and transaminase levels and steatosis of the liver has been seen after early treatment initiation.