bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parameters of long‐term response with CD28‐based CD19 chimaeric antigen receptor‐modified T cells in children and young adults with B‐acute lymphoblastic leukaemia
Authors: Jacoby Elad , Bielorai Bella , Hutt Daphna , Itzhaki Orit , Adam Etai , Bar Diana , Besser Michal J. , Toren Amos 
Published: February 2022

SummaryCD28‐based CD19 chimaeric antigen receptor‐modified (CAR‐)Tcells were recently FDA‐approved for adult acute lymphoblastic leukaemia (ALL). We report long‐term outcome of 37 children and young adults treated with autologous CD19 CAR‐T cells. The complete remission rate was 86%, of which 71% were polymerase chain reaction (PCR) minimal residual disease (MRD)‐negative, 14% were MRD‐negative by flow cytometry, and 14% were PCR MRD‐positive. 26 patients proceeded to subsequent haematopoietic stem cell transplant (HSCT). 11 patients had a CD19‐postive relapse (eight post HSCT and three without) and one had a CD19‐negative relapse. All relapse events occurred within two years from cell therapy. With a median follow‐up of three years, the median event‐free survival (EFS) is 17 months and the median overall survival (OS) is not reached. The three‐year EFS is 41% and OS is 56%. Patients with >5% blasts in the bone marrow prior to lymphodepletion had an inferior EFS. All patients with a PCR MRD‐positive result at day 28 had relapsed after CAR‐T‐cell therapy. A prior HSCT did not significantly affect outcome, but a consolidative transplant after achieving remission improved long‐term results. Overall, prelymphodepletion disease burden and molecular MRD negativity following CAR‐T cells are predictors of long‐term outcome following CD19 CAR‐T‐cell therapy for ALL.
‘Keeping the informal safe’: Strategies for developing peer support initiatives for young people who have experienced sexual violence
Authors: Cody Claire , Bovarnick Silvie , Peace Delphine , Warrington Camille 
Published: February 2022

AbstractThere is increasing recognition of the value of trauma‐informed approaches when working with young people affected by sexual violence. Peer support is a key principle of a trauma‐informed approach; however, there are limited examples of peer support programmes for this group. This paper draws on interviews with 25 respondents with knowledge and experience of peer support initiatives with young people impacted by sexual violence. The article outlines their perspectives on how peer support initiatives – that may be viewed as more ‘risky’ than traditional casework – can be kept ‘safe’. Six strategies are identified together with implications for practice.
Decision‐making challenges: Group dynamics and boundary spanning in the CyberStrike game
Authors: Gibbons Deborah E. , Freeman Michael 
Published: February 2022

AbstractMultirole online games offer advantages for learning in business schools, as students process information and coordinate with others while pursuing measurable goals. Gaming environments can be complex, and the choices and timing of players’ actions may have long‐term effects on the state of the game. Team members practice communication skills as they exchange information and coordinate actions, and games provide objective feedback about their performance. Despite these advantages, integration of multiplayer online games into business courses can present technical and instructional challenges. This article introduces an online game, CyberStrike, in which student teams play roles of state or nonstate actors attempting to protect their own information systems while selectively attacking competitors’ information systems. The game can be useful in organizational behavior courses because it engages students in decision‐making processes and inter‐group dynamics that highlight relevant principles in action. As student teams try to foster cooperation within a competitive environment, consequences of their decision‐making, strategy development, and boundary‐spanning activities become apparent. Guidelines for teaching with CyberStrike are provided, along with suggestions for incorporating multirole online games into business school classes.
Cognitive economics and the Market Mind Hypothesis: Exploring the final frontier of economics
Authors: Schotanus Patrick 
Published: February 2022

AbstractCognitive economics partners cognitive science and economics: cognitive science teaches economics about mentality (present in markets), whereas economics teaches cognitive science about market forces (present in minds). The shared Market Mind principle is intelligent (sometimes conscious) self‐organisation. Specifically, the Market Mind Hypothesis formalises what investors casually refer to as ‘the market's mind’. Prices are its informational signatures while market mood is its phenomenal experience.
VIRTUAL HISTORIOGRAPHY: OPENING HISTORY TOWARD THE FUTURE
Authors: HÖLSCHER LUCIAN 
Published: February 2022

ABSTRACTThis article deals with the conceptual tools of a virtual historiography. This is what I call a historiography that goes beyond factual events to consider the possible alternative interpretations of the course of history without entering the field of counterfactual history. In contrast to counterfactual history, which asks what else could have happened, virtual historiography asks how the past would be seen if it had led to another future. For such a historiographical project, the article offers a set of conceptual tools that allow possible alternative courses of events in the past and present to be brought to the attention of contemporary historians: the concept of time figures for presenting a typology of the temporal directions of historical change (part 1); the concept of the future as a generator of time figures (part 2); the concepts of past futures for developments alternative to the factual course of history and of future pasts for visions of the present state of affairs seen from a future point of view (part 3). In part 4, I outline the significance of these concepts for a virtual historiography, and in part 5, I draw conclusions for the political use and the scale of time implicit in such a design of history.
Douchi ameliorates high‐fat diet‐induced hyperlipidaemia by regulation of intestinal microflora in rats
Authors: An Miaoqing , Xu Ya‐nan , Xiao Nan , Huang Jian‐zhao , Wu Shan‐shan , Zhuo Qianting , Lai Yuping , Chen JianPing , Li Pan , Du Bing 
Published: February 2022

SummaryDouchi are good food for obesity prevention, but limited information is known about the potential relationship between hyperlipidaemic effect and intestinal microbiological regulation of Douci. To explore the hyperlipidaemic effect of Douchi fermented by Rhizopus chinensis 12 on hyperlipidaemia rats and the correlation between intestinal flora and hyperlipidaemic effect. The intervention with Douchi significantly (P < 0.05) reduced the levels of total cholesterol, total triglyceride and low‐density lipoprotein cholesterol, increased the level of high‐density lipoprotein cholesterol, and improved liver damage and fat cell hypertrophy caused by high‐fat diet. Douchi also increased the anti‐ atherosclerosis index and reduced the levels of human oxidized low‐density lipoprotein, tumour necrosis factor‐α, monocyte chemotactic protein‐1, C‐reactive protein, interleukin‐6 and interleukin‐1β. Furthermore, Douchi regulated the expression of key proteins and significantly (P < 0.05) reversed the decrease in the richness and diversity of the gut microbiota caused by high‐fat feeding. The correlation analysis revealed that the relative abundance of Romboutsia was positively correlated with four lipids and inflammatory factors, while that of Lactobacillus, Allobaculum, unidentified_Corynebacterium, Aerococcus, Facklamia, Alcaligenes and unidentified_Clostridiales was negatively correlated. Douchi modulated the activate lipid metabolism and reduced the level of serum inflammatory factors by regulating the balance of the gut microbiota to achieve the anti‐hyperlipidaemic effect.
Genetic parameters estimation and genome‐wide association studies for internal organ traits in an F2 chicken population
Authors: Li Yudong , Liu Xin , Bai Xue , Wang Yuxiang , Leng Li , Zhang Hui , Li Yumao , Cao Zhiping , Luan Peng , Xiao Fan , Gao Haihe , Sun Yuhang , Wang Ning , Li Hui , Wang Shouzhi 
Published: February 2022

AbstractChicken internal organs are indispensable parts of the body, but their genetic architectures have not been commonly understood. Herein, we estimated the genetic parameters for heart weight (HW), liver weight (LW), spleen weight (SpW), testis weight (TW), glandular stomach weight (GSW), muscular stomach weight (MSW) and identified single nucleotide polymorphisms (SNPs) and potential candidate genes associated with internal organ weights in an F2 population constructed by crossing broiler cocks derived from Arbor Acres with high abdominal fat content and Baier layer dams (a Chinese native breed). The restricted maximum likelihood (REML) method was applied for genetic parameters estimation of internal organ weights using GCTA software. The results showed that heritabilities of internal organ traits ranged from 0.336 to 0.673 and most of the genetic and phenotypic correlations amongst internal organs weights were positive. A genome‐wide association study (GWAS) was performed based on a mixed linear model (MLM) in GEMMA software. Genotypic data were produced from the whole genome re‐sequenced (26 F0 individuals were re‐sequenced at 10 × coverage; 519 F2 individuals were re‐sequenced at 3 × coverage). A total of 7,890,258 SNPs remained to be analysed after quality control and genotype imputation. The GWAS results indicated that significant SNPs responsible for internal organ traits were scattered on the different chicken chromosomes 1–5, 8, 11, 14, 16, 18, 19 and 27. Amongst the annotated genes, fibronectin type III domain containing 3A (FNDC3A), LOC101748122, membrane palmitoylated protein 6 (MPP6), LOC107049584 and KAT8 regulatory NSL complex subunit 1 (KANSL1) were the most promising candidates for internal organ traits. The findings will provide instrumental information for understanding the genetic basis of internal organ development.
The needs of families who care for individuals with kidney failure on comprehensive conservative care: A qualitative systematic review
Authors: Ania‐González N. , Martín‐Martín J. , Amezqueta‐Goñi P. , Vázquez‐Calatayud M. 
Published: February 2022

AbstractBackgroundIntegrating the family of patients with kidney failure on comprehensive conservative care could benefit patients, families, and the health care system. However, there is a knowledge gap in this phenomenon since no systematic review has focused on the families' needs who care for individuals with kidney failure on comprehensive conservative care.ObjectivesTo understand the primary needs of families who care for people with kidney failure on comprehensive conservative care.MethodA systematic literature review of qualitative studies, followed by a content analysis was carried out. PubMed, CINAHL, and PsycINFO databases were used to search for articles published in English and Spanish between 2010 and 2021. The ENTREQ guideline was used for reporting.ResultsFive relevant studies were included in this study. The analysis has allowed identifying key aspects of knowledge, psychological, social and spiritual needs of family members of patients with kidney failure on comprehensive conservative care.ConclusionsThis systematic review has revealed that families experience a lack of information and continuity of care by health care professionals. Added to this is the psychological burden they bear due to the feeling of indefinite care in time and uncertainty about the death of their loved one. All this, without the necessary support from their immediate family environment and social institutions. In light of these data, a paradigm shift in society and the health care received by these families is essential.
Exploring patients' experiences of the impact of dialysis therapies on quality of life and wellbeing
Authors: Antoun Joe , Brown Daniel J. , Jones Daniel J. W. , Clarkson Beth G. , Shepherd Anthony I. , Sangala Nicholas C. , Lewis Robert J. , McNarry Melitta A. , Mackintosh Kelly A. , Mason Laura , Corbett Jo , Saynor Zoe L. 
Published: February 2022

AbstractBackgroundWhen people with chronic kidney disease reach kidney failure, renal replacement therapy is usually required to improve symptoms and maintain life. Although in‐centre haemodialysis is most commonly used for this purpose, other forms of dialysis are available, including home haemodialysis and peritoneal dialysis.ObjectivesWe aimed to explore the experiences of adults living with chronic kidney disease who were either approaching the need for dialysis or had reached kidney failure and were receiving a form of dialysis. In particular, we explored how different forms of dialysis affect their quality of life, wellbeing, and physical activity.MethodsIndividual semistructured interviews were conducted with 40 adults with kidney failure, comprising four groups (n = 10 each): those receiving in‐centre haemodialysis, home haemodialysis or peritoneal dialysis, or predialysis. Interviews were transcribed verbatim, thematically analysed, and then composite vignettes were subsequently developed to present a rich narrative of the collective experiences of each group.FindingsCompared with adults who were predialysis, quality of life and wellbeing improved upon initiation of their home haemodialysis or peritoneal dialysis. Conversely, minimal improvement was perceived by those receiving in‐centre haemodialysis. Low physical activity was reported across all four groups, although those receiving home haemodialysis and peritoneal dialysis reported a greater desire and ability to be physically active than those in‐centre.ConclusionThese findings highlight that dialysis modalities not requiring regular hospital attendance (i.e., home haemodialysis and peritoneal dialysis) improve independence, quality of life, wellbeing, and can facilitate a more physically active lifestyle.
Measuring US regional economic uncertainty
Authors: Pan Wei‐Fong , Reade James , Wang Shixuan 
Published: February 2022

AbstractThis study constructs a set of regional economic uncertainty (EU) indices for the United States based on Internet search volumes. These indices shed light on EU at the regional and local levels along with national EU. Although aggregate state‐level EU is highly synchronized, idiosyncratic state EU nonetheless exhibits large variations. Similar to aggregate state‐level EU, idiosyncratic state EU is generally countercyclical. There is also a spillover effect among EU in US regions. Lastly, we show that idiosyncratic state EU foreshadows declines in local employment and output.
Pharmacokinetics and residue elimination of norfloxacin in rainbow trout (Oncorhynchus mykiss)
Authors: Wang Zhuoqun , Yang Yan , Mu Yingchun , Liu Bo , Zhang Pei , Zhang Xin , Sun Huiwu , Song Yi , Cheng Bo 
Published: February 2022

AbstractWe studied the metabolism and elimination of norfloxacin in rainbow trout (Oncorhynchus mykiss) following a single oral administration of 50 mg/kg at 15 ± 2°C. Norfloxacin was measured by high‐performance liquid chromatography‐tandem mass spectrometry in plasma, muscle, liver, kidney, skin and remainder tissues, and the concentrationtime curve was characterized by a double peak. The drug was absorbed rapidly; the first peak appeared within 4 h, and the second peak appeared within 24 h in all substrates tested. The maximal concentrations in plasma, muscle, liver and kidney were 0.468 mg/L, 14.146 mg/kg, 6.445 mg/kg and 0.977 mg/kg, respectively. The distribution half‐life was 5.814, 9.026, 17.027 and 1.004 h, respectively. The elimination half‐life was 41.205, 41.667, 44.896 and 54.908 h, respectively. Using the kidney as the reference tissue for norfloxacin monitoring in aquaculture and 2 μg/kg as a maximum residue limit standard, it takes 555 temperature‐day (°C days) for norfloxacin to be completely eliminated from rainbow trout.
Exploring New Insights Into Explicit and Implicit Second Language Processing: Event‐Related Potentials Analyzed by Source Attribution
Authors: Morgan‐Short Kara , Finestrat Irene , Luque Alicia , Abugaber David 
Published: February 2022

AbstractIn this exploratory study, we considered the method of combining event‐related potentials (ERPs) and source attributions as a means for examining the explicit or implicit nature of second language (L2) knowledge and processing. We recorded electroencephalograms while L2 Spanish participants judged phrase structure and subject‐verb agreement sentences and provided source attributions—guess, intuition, memory, rule. The participants evidenced above chance performance and anterior P600 effects to the stimuli overall. We examined whether ERPs differed by explicit (memory, rule) or implicit (guess, intuition) source attributions. Mixed‐effects models indicated more positive ERPs when the participants indicated explicit source attributions. Thus, the anterior P600 evidenced in our study seemed to reflect subjectively reported explicit knowledge. Future research will be necessary to reproduce this finding, to understand ERP effects that may be associated with implicit knowledge, and to further explore how ERPs may be triangulated with other types of data to better understand the nature of L2.
Temporal dynamics of auditory bistable perception correlated with fluctuation of baseline pupil size
Authors: Suzuki Yuta , Liao Hsin‐I , Furukawa Shigeto 
Published: February 2022

AbstractA dynamic neural network change, accompanied by cognitive shifts such as internal perceptual alternation in bistable stimuli, is reconciled by the discharge of noradrenergic locus coeruleus neurons. Transient pupil dilation as a consequence of the reconciliation with the neural network in bistable perception has been reported to precede the reported perceptual alternation. Here, we found that baseline pupil size, an index of temporal fluctuation of arousal level over a longer range of timescales than that for the transient pupil changes, relates to the frequency of perceptual alternation in auditory bistability. Baseline pupil size was defined as the mean pupil diameter over a period of 1 s prior to the task requirement (i.e., before the observation period for counting the perceptual alternations in Experiment 1 and reporting whether participants experienced the perceptual alternations in Experiment 2). The results showed that the baseline pupil size monotonically increased with an increasing number of perceptual alternations and its occurrence probability. Furthermore, a cross‐correlation analysis indicates that baseline pupil size predicted perceptual alternation at least 35 s before the behavioral response and that the overall correspondence between pupil size and perceptual alternation was maintained over a sustained time window of 45 s at minimum. The overall results suggest that variability of baseline pupil size reflects the stochastic dynamics of arousal fluctuation in the brain related to bistable perception.
Predictors of mortality in subjects with progressive fibrosing interstitial lung diseases
Authors: Brown Kevin K. , Inoue Yoshikazu , Flaherty Kevin R. , Martinez Fernando J. , Cottin Vincent , Bonella Francesco , Cerri Stefania , Danoff Sonye K. , Jouneau Stephane , Goeldner Rainer‐Georg , Schmidt Martin , Stowasser Susanne , Schlenker‐Herceg Rozsa , Wells Athol U. 
Published: February 2022

AbstractBackground and objectiveDemographic and clinical variables, measured at baseline or over time, have been associated with mortality in subjects with progressive fibrosing interstitial lung diseases (ILDs). We used data from the INPULSIS trials in subjects with idiopathic pulmonary fibrosis (IPF) and the INBUILD trial in subjects with other progressive fibrosing ILDs to assess relationships between demographic/clinical variables and mortality.MethodsThe relationships between baseline variables and time‐varying covariates and time to death over 52 weeks were analysed using pooled data from the INPULSIS trials and, separately, the INBUILD trial using a Cox proportional hazards model.ResultsOver 52 weeks, 68/1061 (6.4%) and 33/663 (5.0%) subjects died in the INPULSIS and INBUILD trials, respectively. In the INPULSIS trials, a relative decline in forced vital capacity (FVC) >10% predicted within 12 months (hazard ratio [HR] 3.77) and age (HR 1.03 per 1‐year increase) were associated with increased risk of mortality, while baseline FVC % predicted (HR 0.97 per 1‐unit increase) and diffusing capacity of the lungs for carbon monoxide (DLCO) % predicted (HR 0.77 per 1‐unit increase) were associated with lower risk. In the INBUILD trial, a relative decline in FVC >10% predicted within 12 months (HR 2.60) and a usual interstitial pneumonia‐like fibrotic pattern on HRCT (HR 2.98) were associated with increased risk of mortality, while baseline DLCO % predicted (HR 0.95 per 1‐unit increase) was associated with lower risk.ConclusionThese data support similarity in the course of lung injury between IPF and other progressive fibrosing ILDs and the value of FVC decline as a predictor of mortality.
African Ethics, Respect for Persons, and Moral Dissent
Authors: Jecker Nancy S. 
Published: February 2022

AbstractThis paper examines the ethic of respect for dignity within African relational ethics. Following an introduction to African relational ethics (in Section 1), Section 2 introduces two ways of respecting dignity associated with two strands of African communitarianism: strong and moderate. Section 3 tests each version by considering a challenge case involving an oppressive social structure, the Osu caste system in Igboland (Southeastern Nigeria). It argues that both strong and moderate communitarianism are compatible with respecting the dignity of moral dissenters who oppose the Osu caste system. The result is somewhat surprising: while it is generally held that moderate communitarianism is compatible with respecting dignity, it is often thought that strong communitarianism is not. The final section (Section 4) considers and replies to objections. It concludes that an African relational framework lends strong support to respecting dignity in the case of moral dissent.
A Nominalist Alternative to Reference by Abstraction
Authors: Pearce Gareth Rhys 
Published: February 2022

AbstractIn his recent book Thin Objects, Øystein Linnebo (2018) argues for the existence of a hierarchy of abstract objects, sufficient to model ZFC, via a novel and highly interesting argument that relies on a process called dynamic abstraction. This paper presents a way for a nominalist, someone opposed to the existence of abstract objects, to avoid Linnebo's conclusion by rejecting his claim that certain abstraction principles are sufficient for reference (RBA). Section 1 of the paper explains Linnebo's argument for RBA. It offers a reading of Linnebo's work upon which he has two arguments for RBA: one deductive and one abductive, and argues that whilst the deductive argument is unsound the abductive one is prima facie plausible. The nominalist must therefore find a way to respond to the abductive argument. Section 2 outlines just such a response, by offering an alternative explanation of the cases Linnebo wishes to argue from. Most interestingly, it shows that abstraction in Linnebo's most difficult case (the “reference to ordinary bodies” case) can be achieved using mereological means, rather than relying on RBA.