bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolism modulation in rat tissues in response to point specificity of electroacupuncture
Authors: Lee Der-Yen , Jiu Yu-Rung , Hsieh Ching-Liang 
Published: January 2022

AbstractZusanli (ST36) and Neiguan (PC6) are acupoints along two meridians. To demonstrate point specificity, we investigated the effects of ST36 and PC6 in electroacupuncture (EA)-treated rats. The rats were subjected to sham acupuncture at ST36 without electric stimulation, EA at ST36, or EA at PC6. Heart and stomach tissues were collected for metabolite profiling. Each type of stimulation resulted in a different metabolite composition in the rat heart and stomach tissues. In the heart tissues, EA at ST36 affected a wider range of metabolite pathways than did EA at PC6, whereas similar numbers of metabolites in the stomach tissues were affected by EA at ST36 and PC6. The pathways affected by EA at ST36 differed from those affected by EA at PC6, and a group of common metabolites were reversely regulated by these two acupoints. This study demonstrated point specificity effectively modulated metabolism in rat heart and stomach tissues. The results indicate that heart stimulation may be connected to the stomach through the pericardium meridian (as described in traditional Chinese medicine), explaining why acupuncture applied to the stomach meridian can be an alternative treatment for gastric and heart diseases.
Entropic topography associated with field-induced quantum criticality in a magnetic insulator DyVO4
Authors: Ranaut Dheeraj , Mukherjee K. 
Published: January 2022

AbstractExploration of low temperature phase transitions associated with quantum critical point is one of the most mystifying fields of research which is under intensive focus in recent times. In this work, through comprehensive experimental evidences, we report the possibility of achieving quantum criticality in the neighborhood of a magnetic field-tuned tricritical point separating paramagnetic, antiferromagnetic and metamagnetic phases in a magnetic insulator, DyVO4. Magnetic susceptibility and heat capacity indicate to the presence of a long-range second order antiferromagnetic transition at TN ~ 3.2 K. Field variation of Magnetic susceptibility and heat capacity, along with differential magnetic susceptibility and DC field dependent AC susceptibility gives evidence of the modification of the antiferromagnetic structure below the tricritical point; implying the presence of a field-induced first order metamagnetic transition which persists down to 1.8 K. Further, the magnetic field dependence of the thermodynamic quantity − dM/dT, which is related to magnetic Gruneisen parameter, approaches a minimum, followed by a crossover near 5 kOe to a maximum; along with a hyperbolic divergence in temperature response of dM/dT in the critical field regime. Temperature response of heat capacity at 5 kOe also shows a deviation from the conventional behavior. Entropic topography phase diagram allows tracking of the variation of the entropy, which indicates towards the emergence of the peak at quantum critical point into a V-shaped region at high temperatures. Our studies yield an inimitable phase diagram describing a tricritical point at which the second-order antiferromagnetic phase line terminates followed by a first order line of metamagnetic transition, as the temperature is lowered, leading to metamagnetic quantum critical end point.
The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines
Authors: Kelishadi Mahnaz Rezaei , Naeini Amirmansour Alavi , Khorvash Fariborz , Askari Gholamreza , Heidari Zahra 
Published: January 2022

AbstractThe current study was performed to evaluate the effects of alpha-lipoic acid (ALA) supplementation on lactate, nitric oxide (NO), vascular cell adhesion molecule-1 (VCAM-1) levels, and clinical symptoms in women with episodic migraines. Considering the inclusion and exclusion criteria, ninety-two women with episodic migraines participated in this randomized, double-blind, placebo-controlled, parallel-design trial. The participants were randomly assigned to receive either 300 mg/day ALA or placebo, twice per day for 12 weeks. The primary outcomes included headache severity, headache frequency per month, and duration of attacks and the secondary outcomes included lactate (a marker of mitochondrial function), NO, and VCAM-1 serum levels were measured at baseline and the end of the intervention. At the end of the study, there was a significant decrease in lactate serum levels (− 6.45 ± 0.82 mg/dl vs − 2.27 ± 1.17 mg/dl; P = 0.039) and VCAM-1 (− 2.02 ± 0.30 ng/ml vs − 1.21 ± 0.36 ng/ml; P = 0.025) in the ALA as compared to the placebo group. In addition, the severity (P < 0.001), frequency (P = 0.001), headache impact test (HIT-6) (P < 0.001), headache dairy results (HDR) (P = 0.003), and migraine headache index score (MHIS) (P < 0.001) had significantly decreased in the intervention as compared to the control group. No significant changes were observed for NO levels and duration of migraine pains. ALA supplementation can be considered a potential adjunct treatment in patients with migraine due to its improving mitochondrial and endothelial functions and clinical symptoms.
Monitoring geological storage of CO2 using a new rock physics model
Authors: Fawad Manzar , Mondol Nazmul Haque 
Published: January 2022

AbstractTo mitigate the global warming crisis, one of the effective ways is to capture CO2 at an emitting source and inject it underground in saline aquifers, depleted oil and gas reservoirs, or in coal beds. This process is known as carbon capture and storage (CCS). With CCS, CO2 is considered a waste product that has to be disposed of properly, like sewage and other pollutants. While and after CO2 injection, monitoring of the CO2 storage site is necessary to observe CO2 plume movement and detect potential leakage. For CO2 monitoring, various physical property changes are employed to delineate the plume area and migration pathways with their pros and cons. We introduce a new rock physics model to facilitate the time-lapse estimation of CO2 saturation and possible pressure changes within a CO2 storage reservoir based on physical properties obtained from the prestack seismic inversion. We demonstrate that the CO2 plume delineation, saturation, and pressure changes estimations are possible using a combination of Acoustic Impedance (AI) and P- to S-wave velocity ratio (Vp/Vs) inverted from time-lapse or four-dimensional (4D) seismic. We assumed a scenario over a period of 40 years comprising an initial 25 year injection period. Our results show that monitoring the CO2 plume in terms of extent and saturation can be carried out using our rock physics-derived method. The suggested method, without going into the elastic moduli level, handles the elastic property cubes, which are commonly obtained from the prestack seismic inversion. Pressure changes quantification is also possible within un-cemented sands; however, the stress/cementation coefficient in our proposed model needs further study to relate that with effective stress in various types of sandstones. The three-dimensional (3D) seismic usually covers the area from the reservoir's base to the surface making it possible to detect the CO2 plume's lateral and vertical migration. However, the comparatively low resolution of seismic, the inversion uncertainties, lateral mineral, and shale property variations are some limitations, which warrant consideration. This method can also be applied for the exploration and monitoring of hydrocarbon production.
Study of the variation of the optical properties of calcite with applied stress, useful for specific rock and material mechanics
Authors: Ulian Gianfranco , Valdrè Giovanni 
Published: January 2022

AbstractCalcite (CaCO3, trigonal crystal system, space group$$R\overline{3}c$$R3¯c) is a ubiquitous carbonate phase commonly found on the Earth’s crust that finds many useful applications in both scientific (mineralogy, petrology, geology) and technological fields (optics, sensors, materials technology) because of its peculiar anisotropic physical properties. Among them, photoelasticity, i.e., the variation of the optical properties of the mineral (including birefringence) with the applied stress, could find usefulness in determining the stress state of a rock sample containing calcite by employing simple optical measurements. However, the photoelastic tensor is not easily available from experiments, and affected by high uncertainties. Here we present a theoretical Density Functional Theory approach to obtain both elastic and photoelastic properties of calcite, considering realistic experimental conditions (298 K, 1 atm). The results were compared with those available in literature, further extending the knowledge of the photoelasticity of calcite, and clarifying an experimental discrepancy in the sign of thep41photoelastic tensor component measured in past investigations. The methods here described and applied to a well-known crystalline material can be used to obtain the photoelastic properties of other minerals and/or materials at desired pressure and temperature conditions.
Amine-substituent induced highly selective and rapid “turn-on” detection of carcinogenic 1,4-dioxane from purely aqueous and vapour phase with novel post-synthetically modified d10-MOFs
Authors: Mondal Udayan , Bej Sourav , Hazra Abhijit , Mandal Sukdeb , Pal Tapan K. , Banerjee Priyabrata 
Published: January 2022

Amine-functionalized post-synthetically modified d10 MOFs for selective and rapid 'turn-on' recognition of carcinogenic 1,4-dioxane from aqueous medium and vapour phase
Palladium-Catalyzed Thiocarbonylations with Triisopropylsilyl Thioethers
Authors: Nakada Masahisa , Hosoya Yosuke , Mizoguchi Kota , Yasukochi Honoka 
Published: January 2022

AbstractWe have developed a palladium-catalyzed thiocarbonylation through the reaction of a σ-alkyl palladium intermediate with carbon monoxide and a triisopropylsilyl (TIPS) thioether. The use of CsF, (IPr)Pd(allyl)Cl [IPr =1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene], CO, and a TIPS thioether in THF are key to obtaining alkyl and aryl thioesters in high yields. The yield of the palladium-catalyzed thiocarbonylation depended on the structure of the substrate; indoline-2-one derivatives were formed faster than indoline derivatives. The reactions of benzoyl and hydrocinnamoyl fluorides with TIPSSPh and CsF also gave the corresponding thioesters.
Andexanet Alfa for Specific Anticoagulation Reversal in Patients with Acute Bleeding during Treatment with Edoxaban
Authors: Benz Alexander P. , Xu Lizhen , Eikelboom John W. , Middeldorp Saskia , Milling Truman J. , Crowther Mark , Yue Patrick , Conley Pamela , Lu Genmin , Connolly Stuart J. ,   on behalf of the ANNEXA-4 Investigators
Published: January 2022

Abstract
Background Andexanet alfa (andexanet) is approved for specific anticoagulation reversal in patients with life-threatening or uncontrolled bleeding during treatment with rivaroxaban or apixaban. There is limited experience with andexanet in patients with acute bleeding on edoxaban.
Methods Patients with acute major bleeding within 18 hours of edoxaban intake were prospectively enrolled. Patients received a bolus and 2-hour follow-on infusion of andexanet. The co-primary efficacy outcomes were change in antifactor Xa activity and the percentage of patients achieving excellent or good hemostasis, 12 hours after andexanet treatment. Efficacy was analyzed in patients with confirmed major bleeding and baseline antifactor Xa activity ≥40 ng/mL. Safety was analyzed in all patients.
Results Thirty-six patients (mean age: 82 years, 61.1% male and 91.7% with atrial fibrillation) with acute major bleeding on edoxaban received andexanet. The primary site of bleeding was intracranial in 29 patients (80.6%). In the efficacy population (n = 28), median antifactor Xa activity decreased from 121.1 (interquartile range [IQR]: 70.3–202.4) ng/mL at baseline to 24.0 (IQR: 77.7–83.7) ng/mL at the end of andexanet bolus (median decrease: 68.9%, 95% confidence interval [CI]: 56.1–77.7%). Excellent or good hemostasis at 12 hours was achieved in 78.6% (95% CI: 59.0–91.7%) of patients. Within 30 days, four patients (11.1%) experienced a thrombotic event and four others (11.1%) died.
Conclusion In patients with acute major bleeding on edoxaban, andexanet significantly decreased antifactor Xa activity. Hemostatic efficacy was similar to that observed in patients with bleeding on rivaroxaban or apixaban. Thrombotic events occurred at a rate expected in such patients.
Efficacy and Tolerability of Lacosamide in Lennox–Gastaut Syndrome: A Systematic Review and Meta-analysis
Authors: Panda Prateek Kumar , Sharawat Indar Kumar , Dawman Lesa , Panda Pragnya , Kasinathan Ananthanarayanan , Rathaur Vyas Kumar 
Published: January 2022

Abstract

Purpose Lennox–Gastaut syndrome (LGS) is one of the most difficult to treat childhood-onset epileptic encephalopathies. There is growing evidence that lacosamide is safe and efficacious in patients and adults with refractory epilepsy. However, the evidence regarding the efficacy of lacosamide in LGS is controversial so far. We aimed to evaluate the efficacy and tolerability of lacosamide in patients with LGS.

Methods We conducted a systematic review on MEDLINE, EMBASE, COCHRANE CENTRAL, Google Scholar, and Web of Science, collating all available literature till July 31, 2020. The qualitative review included case reports, case series, and both controlled/uncontrolled trials as well as retrospective studies, but for determining pooled estimates, we only included studies with a sample size of 5 or more. The primary outcome was the efficacy of lacosamide in patients with LGS. Clinical variables related to efficacy and adverse events attributed to lacosamide were extracted from each publication. The pooled estimate of variables related to these parameters was performed using a random-effect model.

Results Of the 68 items identified by the search, 14 were reviewed as full-text. Eleven articles including two prospective and six retrospective studies fulfilled eligibility criteria and described outcomes in 81 patients (42 adults, 39 children, 60% male, range—1.4–61 years). On average, 35.2%, 27.9%, 7.3%, and 29.4% patients had > 50% reduction, < 50% reduction, no change, and worsening of seizure frequency, respectively. Although 36% of patients had adverse events like somnolence, behavioral abnormalities including irritability, aggressiveness, nausea, tremor, memory problems, dizziness, gastrointestinal discomfort, vomiting, and weight loss, no serious adverse events were noted.

Conclusion The evidence available in the current literature is not sufficient to support or refute the use of lacosamide in patients with LGS. Although it is one of the possible therapeutic options worth exploring in patients with LGS, caution is still necessary, as there are reports of worsening of seizure frequency in some patients.
Reconciling fragmented sectors of health research regulation: toward an ecosystem of processual regulation
Authors: Frowde Rhiannon L. , Dove Edward S. , Laurie Graeme T. 
Published: January 2022

AbstractThe delivery of good outcomes from human health research is entirely dependent on the proper functioning of the attendant regulatory systems. This article focuses on the processes of regulation themselves, and how these might be better understood, so that regulators and other stakeholders have a strong normative basis upon which to pursue the regulatory objective of achieving outcomes with maximum social value. The argument is made that the concept of ‘processual regulation’—which promotes a whole systems approach to regulation—can assist greatly in the design, implementation, and review of human health research. This moves beyond the current often-fragmented approach to regulation towards a joined-up, reflective, and responsive system that has fitness-for-purpose at its core.
Banking disclosure and banking crises in Africa: does board gender diversity play a role?
Authors: Ofori-Sasu Daniel , Sarpong Maame Ofewah , Tetteh Vivian , Kusi Baah Aye 
Published: January 2022

AbstractThe paper aims to investigate the impact of board gender diversity in explaining the relationship between bank disclosure and the predicted probability of banking crises in Africa. The study employs robust panel estimates based on an aggregate dataset of banks in 42 African countries over the 2006–2018 periods. From the study, board gender diversity (more women on boards and the presence of women on boards) has a positive impact on information disclosure of banks. We find that board gender diversity and bank disclosure have the possibility of reducing a banking crisis. We observe that board gender diversity enhances the reductive effect of bank disclosure on a predicted probability of a banking crisis. The implication is that women on boards provide prudent decisions on financial information disclosure that significantly reduce the possibility of a banking crises in order to ensure stable banking systems.
Imaging active site chemistry and protonation states: NMR crystallography of the tryptophan synthase α-aminoacrylate intermediate
Authors: Holmes Jacob B. , Liu Viktoriia , Caulkins Bethany G. , Hilario Eduardo , Ghosh Rittik K. , Drago Victoria N. , Young Robert P. , Romero Jennifer A. , Gill Adam D. , Bogie Paul M. , Paulino Joana , Wang Xiaoling , Riviere Gwladys , Bosken Yuliana K. , Struppe Jochem , Hassan Alia , Guidoulianov Jevgeni , Perrone Barbara , Mentink-Vigier Frederic , Chang Chia-en A. , Long Joanna R. , Hooley Richard J. , Mueser Timothy C. , Dunn Michael F. , Mueller Leonard J. 
Published: January 2022

SignificanceThe determination of active site protonation states is critical for a full mechanistic understanding of enzymatic transformations. However, hydrogen atom positions are challenging to extract using the standard tools of structural biology. Here, we make use of a joint solid-state NMR, X-ray crystallography, and first-principles computational approach that enables the investigation of enzyme catalysis at this fine level of chemical detail. For tryptophan synthase, this allows us to peer along the reaction coordinates into and out of the α-aminoacrylate intermediate. Through this process, we are developing a high-resolution probe for structural biology that is keenly sensitive to hydrogen atom positions—complementing diffraction methods yet able to be applied under conditions of active catalysis in microcrystalline and non-crystalline materials.
Asymptotic quasinormal frequencies of different spin fields in d-dimensional spherically-symmetric black holes
Authors: Chen Chun-Hung , Cho Hing-Tong , Chrysostomou Anna , Cornell Alan S 
Published: January 2022

Abstract
While Hod’s conjecture is demonstrably restrictive, the link he observed between black hole (BH) area quantisation and the large overtone (n) limit of quasinormal frequencies (QNFs) motivated intense scrutiny of the regime, from which an improved understanding of asymptotic quasinormal frequencies (aQNFs) emerged. A further outcome was the development of the ‘monodromy technique’, which exploits an anti-Stokes line analysis to extract physical solutions from the complex plane. Here, we use the monodromy technique to validate extant aQNF expressions for perturbations of integer spin, and provide new results for the aQNFs of half-integer spins within higher-dimensional Schwarzschild, Reissner–Nordström, and Schwarzschild (anti-)de Sitter BH spacetimes. Bar the Schwarzschild anti-de Sitter case, the spin-1/2 aQNFs are purely imaginary; the spin-3/2 aQNFs resemble spin-1/2 aQNFs in Schwarzschild and Schwarzschild de Sitter BHs, but match the gravitational perturbations for most others. Particularly for Schwarzschild, extremal Reissner–Nordström, and several Schwarzschild de Sitter cases, the application of n → ∞ generally fixes

R
e

{

ω

}

and allows for the unbounded growth of

I
m

{

ω

}

in fixed quantities.
A study on the isolated photon production in nuclear collisions at the CERN-LHC energies
Authors: Sampaio dos Santos G , Gil da Silveira G , Machado M V T 
Published: January 2022

Abstract
An analysis of prompt photon production in high energy nuclear collisions at the Large Hadron Collider is performed within the parton saturation picture taking into account the updated phenomenological color dipole models. Comparison between ⟨N
coll⟩ scaling for hard scattering in heavy-ion collisions and the N
part-scaling based on geometric scaling arguments has been done. The predictions are parameter free in the first case whereas a dependence on the constant of proportionality κ between the number of participants and the nuclear saturation scale appears in the second case. This parameter has been analyzed in the prompt photon spectrum at small transverse momentum even though no fitting procedure was performed. Results are confronted with the measurements made by the ALICE, ATLAS, and CMS experiments in terms of photon transverse momentum at different rapidity bins. We show that the prompt photon production exhibits distinct scalings in AA events associated to geometrical properties of the collision and can be properly addressed in the color dipole formalism. Based on the N
part-scaling, an analytical parametrization for the invariant cross section is provided and employed to predict the x
T-scaling in measurements. For κ of order of unit the theoretical scaling curve correctly describes data in the range x
T ⩽ 5 × 10−2.
Pyrochlore oxide Hg2Os2O7 on verge of metal–insulator boundary
Authors: Kataoka Kota , Hirai Daigorou , Koda Akihiro , Kadono Ryosuke , Honda Takashi , Hiroi Zenji 
Published: January 2022

Abstract
Semimetallic osmium pyrochlore oxide Cd2Os2O7 undergoes a magnetic transition to an all-in–all-out (AIAO)-type order at 227 K, followed by a crossover to an AIAO insulator at around 210 K. Here, we studied the isostructural and isoelectronic compound Hg2Os2O7 through thermodynamic measurements, muon spin rotation (μSR) spectroscopy and neutron diffraction experiments. A similar magnetic transition, probably to an AIAO-type order, was observed at 88 K, while the resistivity showed a decrease at the transition and remained metallic down to 2 K. Thus, the ground state of Hg2Os2O7 is most likely an AIAO semimetal, which is analogous to the intermediate-temperature state of Cd2Os2O7. Hg2Os2O7 exists on the verge of the metal–insulator boundary on the metal side and provides an excellent platform for studying the electronic instability of 5d electrons with moderate electron correlations and strong spin–orbit interactions.
Spatially varying chemical phase formation on silicon nano ripple by low energy mixed ions bombardment
Authors: Mukherjee Joy , Bhowmik Dipak , Bhattacharyya Gourab , Satpati Biswarup , Karmakar Prasanta 
Published: January 2022

Abstract
We report mixed (CO+ and N2
+) ion beam induced spatially varying chemical phases formation on Si (100) surface in nanometer length scale. Simultaneous bombardment of carbon, oxygen and nitrogen like three reactive ions leads to well-defined ripple development and spatially varying periodic chemical phases formation. Post bombardment chemical changes of Si surface are investigated by x-ray photoelectron spectroscopy, and spatially resolved periodic variation of chemical phases are confirmed by electron energy loss spectroscopy. The thickness of ion modified amorphous layer, estimated by Monte Carlo simulation (SRIM), is in excellent agreement with the cross-sectional transmission electron microscopy measurements. The formation of such periodic nanoscale ripple having multiple chemical phases at different parts is explained in terms of chemical instability, local ion flux variation and difference in sputtering yield. Potential applications of such newly developed nano material are also addressed.