bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is it all about knowledge? A survey of attitudes toward ADHD among German pediatricians
Authors: Fechner Marie E. , Mazheika Yuliya , Fehr Folkert , Jung Ronny , Borusiak Peter 
Published: September 2022

Abstract
Aim
Sometimes treatment is not necessarily according to guidelines, which is partly due to attitudes rather than lack of knowledge. In Germany, regional differences concerning prevalence rates of ADHD exist without valid explanation. We contribute with our data to the question of attitudes toward ADHD among pediatricians in Germany.

Method
A specially designed questionnaire based on the Knowledge of Attention Deficit Disorders Scale and previous surveys was sent to pediatricians. In addition to descriptive statistics, we performed factor analysis and multiple linear regression analysis.

Results
The vast majority (85.5%) of 581 respondents have a positive attitude toward ADHD, i.e., ADHD exists and should be treated appropriately. Physicians with positive attitudes were older and more often had a neuropediatric specialization.

Conclusion
Most of the pediatricians surveyed in Germany assess ADHD and treatment in line with medical guidelines and treat as part of multimodal therapy.
Symplectic Reduction of Classical Mechanics on Shape Space
Authors: Tokasi Sahand , Pickl Peter 
Published: September 2022

AbstractOne of the foremost goals of research in physics is to find the most basic and universal theories that describe our universe. Many theories assume the presence of absolute space and time in which the physical objects are located and physical processes take place. However, it is more fundamental to understand time as relative to the motion of another object, e.g., the number of swings of a pendulum, and the position of an object primarily relative to other objects. This paper aims to explain how using the principle of relationalism (to be introduced below), classical mechanics can be formulated on a most elementary space, which is freed from absolute entities: shape space. In shape space, only the relative orientation and length of subsystems are taken into account. A sufficient requirement for the validity of the principle of relationalism is that by changing a system’s scale variable, all the theory’s parameters that depend on the length, get changed accordingly. In particular, a direct implementation of the principle of relationalism introduces a proper transformation of the coupling constants of the interaction potentials in classical physics. This change leads consequently to a transformation in Planck’s measuring units, which enables us to derive a metric on shape space in a unique way. In order to find out the classical equations of motion on shape space, the method of “symplectic reduction of Hamiltonian systems” is extended to include scale transformations. In particular, we will give the derivation of the reduced Hamiltonian and symplectic form on shape space, and in this way, the reduction of a classical system with respect to the entire similarity group is achieved.
Immune Response to SARS-CoV-2 Infections in Children with Secondary Immunodeficiencies
Authors: Kuczborska Karolina , Krzemińska Ewelina , Buda Piotr , Heropolitańska-Pliszka Edyta , Piątosa Barbara , Książyk Janusz 
Published: September 2022

Abstract

Background and Purpose
It is a matter of research, whether children with immunodeficiencies are able to generate an effective immune response to prevent SARS-CoV-2 reinfection. This study aimed to evaluate and compare the seroconversion rates and changes of lymphocyte subsets during COVID-19 in immunocompetent children and those with secondary immunodeficiencies.

Methods
In 55 children — 28 immunocompromised and 27 immunocompetent — hospitalized with confirmed SARS-CoV-2 infection, the level of IgG antibodies against the Spike protein was determined on two to three occasions. In those children from the study group whose immunosuppressive treatment did not alter during the study (n = 13) and in selected children from the control group (n = 11), flow cytometric evaluation of lymphocyte subsets was performed twice — 2 weeks and 3 months post-infection.

Results
Seroconversion reached 96.3% in both studied groups; however, the immunocompromised cohort achieved lower titers of detectable anti-S antibodies. There was no correlation between seroconversion or titers of antibodies and the total number of lymphocytes or their subsets. In the immunocompetent cohort, we reported a significant decrease in NK cells during the infection. In this group and the entire study population, a positive correlation was noticed between the CD4 + /CD8 + T cell ratio and the severity of COVID-19 pneumonia.

Conclusions
Children with secondary immunodeficiencies seroconvert in equal percentages but with a significantly lower titer of anti-S antibodies compared to their immunocompetent peers. The lower number of NK cells in the immunocompetent cohort may result from their participation in antiviral immunity, whereas reduced CD4 + /CD8 + T cell ratios among immunocompromised children may be a protective factor against a severe COVID-19.
Identification of the Sex Pheromone of the Pink Grass Worm, Tmetolophota atristriga, Reveals Possible Population Differences in Male Response to Sex Pheromone
Authors: El-Sayed Ashraf M. , Manning Lee-Anne M. 
Published: September 2022

Abstract
The pink grass worm, Tmetolophota atristriga (Walker), is an endemic New Zealand noctuid moth species that is abundant throughout the North and South Islands. The larvae are minor defoliators of agricultural pasture. We investigated the sex pheromone of this species. Analysis of extract of the female sex pheromone gland identified six compounds: two monounsaturated compounds, (Z)-11-hexadecenal (Z11-16:Ald) and (Z)-11-hexadecenyl acetate (Z11-16:Ac), three saturated compounds, hexadecanal (16:Ald), hexadecyl acetate (16:Ac) and octadecan-1-ol (18:OH), and a triene hydrocarbon, (3Z,6Z,9Z)-tricosatriene (Z3Z6Z9-23:Hy). Several field-trapping experiments testing combinations of the six compounds were conducted. Results suggested that males of two different populations of T. atristriga responded differently to different blends of the compounds. Males of one population responded equally to a two-component blend as to other blends, including the one with all six compounds. By contrast, males of the second population responded only to the six-component blend or a ternary blend of Z11-16:Ald, Z11-16:Ac and Z3Z6Z9-23:Hy. In experiments testing different doses of Z11-16:Ald and Z11-16:Ac in a binary or a six-component blend, a 1 mg dose of the binary blend gave the greatest male catch for both populations. This is the second sex pheromone identification of a New Zealand species of Noctuidae and is the first reported occurrence of Z3Z6Z9-23:Hy as a sex pheromone component of any noctuid species.
The evolution of the law of random processes in the analysis of dynamic systems
Authors: Lucchesi M. , Pintucchi B. , Zani N. 
Published: September 2022

AbstractThe paper presents a method for determining the evolution of the cumulative distribution function of random processes which are encountered in the study of dynamic systems with some uncertainties in the characterizing parameters. It is proved that these distribution functions are the solution of a partial differential equation, whose coefficients can be determined once the dynamic system has been solved, and whose numerical solution can be obtained with the finite difference method. Two simple problems are solved here both explicitly and numerically, then the obtained results are compared with each other.
Ready-to-use deep-learning surrogate models for problems with spatially variable inputs and outputs
Authors: He Xuzhen , Xu Haoding , Sheng Daichao 
Published: September 2022

AbstractData-driven intelligent surrogate models gain popularity recently. Particularly in Monte-Carlo-style stochastic analysis, the influencing factors are considered as inputs, the quantities of interest are considered as outputs, and cheaper-to-evaluate surrogates models are built from a small amount of sample data and are used for the full Monte-Carlo analysis. This paper presents a framework with three innovations: (1) we build surrogate models for a particular problem that covers any possible material properties or boundary conditions commonly encountered in practice, so the models are ready to use, and do not require new data or training anymore. (2) The inputs and outputs to the problem are both spatially variable. Even after discretization, the input and output sizes are in the order of tens of thousands, which is challenging for traditional machine-learning algorithms. We take the footing failure mechanism as an example. Two types of neural networks are examined, fully connected networks and deep neural networks with complicated non-sequential structures (a modified U-Net). (3) This study is also the first attempt to use U-Nets as surrogate models for geotechnical problems. Results show that fully connected networks can fit well simple problems with a small input and output size, but fail for complex problems. Deep neural networks that account for the data structure give better results.
Rereading Habermas in Times of CRISPR-cas: A Critique of and an Alternative to the Instrumentalist Interpretation of the Human Nature Argument
Authors: Wienmeister Annett 
Published: September 2022

AbstractHabermas’s argument from human nature, which speaks in favour of holding back the use of human germline editing for purposes of enhancement, has lately received criticism anew. Prominent are objections to its supposedly genetic essentialist and determinist framework, which underestimates social impacts on human development. I argue that this criticism originates from an instrumentalist reading of Habermas’s argument, which wrongly focuses on empirical conditions and means-ends-relations. Drawing on Habermas’s distinction of a threefold use of practical reason, I show how an alternative—the ethical—reading avoids essentialist and determinist objections by addressing an existential level of sense making. I present three reasons that speak in favour of the ethical reading and I demonstrate how it incorporates social aspects of character formation. Habermas’s account therefore offers exactly what the critics claim is missing. The paper concludes with a conceptual challenge that the ethical reading has to face within Habermas’s overall approach to genetic engineering.
Regularity of a Distribution and of the Boundary of Its Support
Authors: Boman Jan 
Published: September 2022

AbstractIn two recent papers, Boman (J Geom Anal 31:2726–2741, 2020, https://doi.org/10.1007/s12220-020-00372-8, J Ill-posed Inverse Probl 2021, https://doi.org/10.1515/jiip-2020-0139), we proved that the Radon transform of a compactly supported distribution can be supported in the set of supporting planes to a bounded, convex domain $$D\subset {\mathbb {R}}^n$$

D
⊂

R

n

only if the boundary of D is an ellipsoid. Using closely related methods we study here the relationship between the analytic wave front set for the characteristic function, $$\chi _D$$

χ
D

, of a domain $$D \subset {\mathbb {R}}^n$$

D
⊂

R

n

and singularities of the boundary $$\partial D$$

∂
D

of the domain. For instance we prove that the boundary surface must be real analytic in a neighborhood of a point $$z \in \partial D \in C^1$$

z
∈
∂
D
∈

C
1

, if the analytic wave front set of $$\chi _D$$

χ
D

at z contains no other elements than the conormals to $$\partial D$$

∂
D

at z.
Who to Observe and Imitate in Humans and Robots: The Importance of Motivational Factors
Authors: Chevalère Johann , Kirtay Murat , Hafner Verena V. , Lazarides Rebecca 
Published: September 2022

AbstractImitation is a vital skill that humans leverage in various situations. Humans achieve imitation by observing others with apparent ease. Yet, in reality, it is computationally expensive to model on artificial agents (e.g., social robots) to acquire new skills by imitating an expert agent. Although learning through imitation has been extensively addressed in the robotic literature, most studies focus on answering the following questions:whatto imitate andhowto imitate.In this conceptual paper, we focus on one of the overlooked questions of imitation through observation:whoto imitate. We present possible answers to thewho-to-imitate question by exploring motivational factors documented in psychological research and their possible implementation in robotics. To this end, we focus on two critical instances of thewho-to-imitate question that guide agents to prioritize one demonstrator over another: outcome expectancies, viewed as the anticipated learning gains, and efficacy expectations, viewed as the anticipated costs of performing actions, respectively.
A family of non-modular covariant AQFTs
Authors: Morinelli Vincenzo , Neeb Karl-Hermann 
Published: September 2022

AbstractBased on the construction provided in our paper “Covariant homogeneous nets of standard subspaces”, Comm Math Phys 386:305–358, (2021), we construct non-modular covariant one-particle nets on the two-dimensional de Sitter spacetime and on the three-dimensional Minkowski space.
ABCA6 affects the malignancy of Ewing sarcoma cells via cholesterol-guided inhibition of the IGF1R/AKT/MDM2 axis
Authors: Pasello Michela , Giudice Anna Maria , Cristalli Camilla , Manara Maria Cristina , Mancarella Caterina , Parra Alessandro , Serra Massimo , Magagnoli Giovanna , Cidre-Aranaz Florencia , Grünewald Thomas G. P. , Bini Carla , Lollini Pier-Luigi , Longhi Alessandra , Donati Davide Maria , Scotlandi Katia 
Published: September 2022

Abstract
Purpose
The relevance of the subfamily A members of ATP-binding cassette (ABCA) transporters as biomarkers of risk and response is emerging in different tumors, but their mechanisms of action have only been partially defined. In this work, we investigated their role in Ewing sarcoma (EWS), a pediatric cancer with unmet clinical issues.

Methods
The expression of ABC members was evaluated by RT-qPCR in patients with localized EWS. The correlation with clinical outcome was established in different datasets using univariate and multivariate statistical methods. Functional studies were conducted in cell lines from patient-derived xenografts (PDXs) using gain- or loss-of-function approaches. The impact of intracellular cholesterol levels and cholesterol lowering drugs on malignant parameters was considered.

Results
We found that ABCA6, which is usually poorly expressed in EWS, when upregulated became a prognostic factor of a favorable outcome in patients. Mechanistically, high expression of ABCA6 impaired cell migration and increased cell chemosensitivity by diminishing the intracellular levels of cholesterol and by constitutive IGF1R/AKT/mTOR expression/activation. Accordingly, while exposure of cells to exogenous cholesterol increased AKT/mTOR activation, the cholesterol lowering drug simvastatin inhibited IGF1R/AKT/mTOR signaling and prevented Ser166 phosphorylation of MDM2. This, in turn, favored p53 activation and enhanced pro-apoptotic effects of doxorubicin.

Conclusions
Our study reveals that ABCA6 acts as tumor suppressor in EWS cells via cholesterol-mediated inhibition of IGF1R/AKT/MDM2 signaling, which promotes the pro-apoptotic effects of doxorubicin and reduces cell migration. Our findings also support a role of ABCA6 as biomarker of EWS progression and sustains its assessment for a more rational use of statins as adjuvant drugs.
An Investigation of the Bifurcation Behavior of an F-18 Aircraft Model
Authors: Cheng Lifang , Hu Dongpo , Zhang Litao 
Published: September 2022

AbstractBifurcations of equilibria and limit cycles of an F-18 aircraft model have been investigated in this paper based on one or two continuation parameters. First, it is shown that the aircraft can be in a stable straight-and-level flight state by coordinating the elevator deflection and the engine thrust and fixing the other parameters. Second, the aircraft may be disturbed by perturbations out of the longitudinal plane and get into the lateral-directional motion mode by a branch point bifurcation. Third, when the straight flight state loses its stability, body axis angular rates will present periodic or quasi-periodic motion pattern by the Hopf or Neimark–Sacker bifurcation. Finally, bifurcation structure of limit cycles has been exhibited, including the generalized Hopf bifurcation, the Neimark–Sacker bifurcation, the Hopf-Hopf bifurcation and the fold-Neimark–Sacker bifurcation. Meanwhile corresponding bifurcation curves in two-parameter plane have been depicted with the help of numerical continuation techniques.
Trust, Democracy, and Hygiene Theatre: Taiwan’s Evasion of the Pandemic
Authors: Leflar Robert B 
Published: September 2022

AbstractTaiwan’s record of preventing infections and deaths from COVID-19 outshines that of almost every other nation, far outstripping the performance of the US, all European countries, and almost all Asian countries. Yet Taiwan is the nation closest to Wuhan, font of the pandemic. Equally importantly, Taiwan’s public health achievement has occurred without the government dictates such as business and residential lockdowns that have aroused controversy and caused economic and psychological distress around the globe. This essay relates the story of Taiwan’s actions during the crucial early months of 2020 and explores the factors—historical, geographical, legal, institutional, strategic, and cultural—accounting for Taiwan’s remarkable success. Prominent among those factors are the legal and institutional infrastructure of preparedness that Taiwan constructed following its unhappy experience with the 2003 SARS outbreak, and the prompt and decisive measures taken upon discovery of the Wuhan outbreak on 31 December 2019. A dialogue between the judiciary and the legislative and executive branches of government following the SARS episode enabled the infrastructure of preparedness to be created through a process consonant with democratic government, respecting principles of individual liberty and fairness. Risk communication techniques were skilfully employed to build public trust in expert advice about measures for infection prevention. Persuasion, not compulsion, was the norm. Cultural factors including customary acceptance of mask-wearing and authoritative advice, and perhaps a high level of risk-aversity, also played an important part. Taiwan’s pandemic control policies have drawn criticism of government overreach. Some recommendations, such as for outdoor masking, bear little rational relation to infection prevention and are best characterized as mere “hygiene theatre.” Nevertheless, early-2020 government measures received a high level of public approval. Taiwan’s successful response to the pandemic illustrates the nation’s nature: a disciplined democracy.
Studying Democracy in Europe: Conceptualization, Measurement and Indices
Authors: Graziano Paolo , Quaranta Mario 
Published: September 2022

AbstractGiven the academic and media salience of democracy and its measurement, in this contribution we take a closer look at the various existing datasets. For this purpose, in the first two sections we look at democratic conceptualization and measurement, and then focus on the most used datasets on democracy and assess them against the conceptual criteria illustrated in the first section. The third section focuses on the notion of quality of democracy and how it has advanced the understanding of contemporary democracies. The subsequent section illustrates changes in democratic scoring in European countries over the past 15 years. Our results show that democracy has not become more robust in European countries: on the contrary, several countries witnessed significant democratic deterioration. Furthermore, we show that – with the exception of Polity – the indexes analysed are highly correlated and therefore could be equally useful for an ongoing analysis of European democracies.
Back to the Motherland? Parsi Gujarati Travelogues of Iran in the Qajar-Pahlavi Interregnum, 1921–1925
Authors: Ranganathan Murali 
Published: September 2022

AbstractThe publication of four Gujarati travelogues written by Parsis traveling to Iran in quick succession in the 1920s marked the intensification of a relationship that had hitherto been based mainly on philanthropy directed towards the Zoroastrians of Iran. The Pahlavi regime, with its assurances of religious tolerance and equity, prompted Parsis to consider deepening their connection with Iran through trade and business investments and also examine the possibility of return to their motherland. The encounters which constitute these travelogues could be framed as experiments which helped the Parsi community in India to construct a framework for developing this relationship. The Parsi travelogues, while attempting to recover a Zoroastrian past in Iran, also try to map the future for the community by addressing its present anxieties and aspirations.
Stability of thermocapillary flow in liquid bridges fully coupled to the gas phase
Authors: Stojanović Mario , Romanò Francesco , Kuhlmann Hendrik C. 
Published: September 2022

The linear stability of the axisymmetric steady thermocapillary flow in a liquid bridge made from 2 cSt silicone oil (Prandtl number 28) is investigated numerically in the framework of the Boussinesq approximation. The flow and temperature fields in the surrounding gas phase (air) are taken into account for a generic cylindrical container hosting the liquid bridge. The flows in the liquid and in the gas are fully coupled across the hydrostatically deformed liquid–gas interface, neglecting dynamic interface deformations. Originating from a common reference case, the linear stability boundary is computed varying the length of the liquid bridge (aspect ratio), its volume and the gravity level, providing accurate critical data. The qualitative dependence of the critical threshold on these parameters is explained in terms of the characteristics of the critical mode. The heat exchange between the ambient gas and the liquid bridge that is fully resolved has an important influence on the critical conditions.
Mothers’ feeding practices among infants (4–12 months) and associated factors: a cross-sectional study in Saudi Arabia
Authors: Albar Salwa Ali 
Published: September 2022

Abstract
A global target of increasing exclusive breast-feeding (EBF) to at least 50 % by the year 2025 was set by the WHO for infants under 6 months. The lowest prevalence in the world was found in the Eastern Mediterranean region in 2010–18 and little is known about the status of mothers’ feeding practices in Saudi Arabia. The present study aimed to assess mothers’ actual feeding and weaning practices used with their infants by the mothers’ different age groups. The present study was conducted among 247 mothers of infants aged 4–12 months who were attending public well-baby clinics. Quantitative data were obtained by nutritionists using an electronic semi-structured questionnaire about mothers’ feeding practices. Only 5·3 % of mothers engaged in EBF, 44·9 % breast-fed their infants after an hour of birth, while 92·7 % of infants had ever been breast-fed. The average intent/plan to continue breast-feeding was 4·9(±3·1) months. Younger mothers introduced weaning food around 4 weeks earlier than older mothers (mean differences were −0·4, 95 % CI −0·71, −0·13; P = 0·031). A total of 64·3 % of infants received complementary feeding before completing 17 weeks. Maternal age group and delivery mode were the only factors associated with the early introduction of complementary feeding. A total of 69·2 % of the mothers believed that ‘it is a good time’ and 61·1 % felt that ‘infants are hungry and need other sources of food’. Online sources and family advice were the top sources of information on mothers’ feeding practices. Provision of professional advice about EBF and optimal weaning practices are significant areas for improvement in terms of compliance with recommended infant feeding practices.