bluuebunny/crossref_metadata_2025_split huggingface dataset:
Friedrich Jodl (1849–1914) – ein Vorausgänger des Wiener Kreises
Authors: Belke Ingrid 
Published: April 2022

ZusammenfassungFriedrich Jodl war – nach seinem relativ frühen Tod 1914 – schon Ende der 1920er-Jahre fast vergessen, obwohl seine Frau, Margarete Jodl, mit einer Biographie und Freunde und Schüler mit der Edition seiner Werke dafür sorgten, dass er in Erinnerung bleibe. Mit seinem mutigenAuftreten gegen den Klerikalismus in Österreich, mit seinen Veröffentlichungen, die ihn als engagierten Verfechter der Aufklärung und Anhänger von Ludwig Feuerbach ausweisen, galt er schon zu Lebzeiten als „unbequem“. In fast allen größeren Darstellungen des Wiener Kreises wird Jodl als engagiertes Mitglied der Wiener Reformbewegung wenigstens genannt – im Unterschied zu dem Physiker und Philosophen Ernst Mach, dessen Leben und Werk bis heute in vielen Monographien, Aufsätzen und Ausstellungen gewürdigt wird. Ich möchte deshalb in diesem Beitrag Friedrich Jodl in einigen Schwerpunkten vorstellen.
W + charm production with massive c quarks in PowHel
Authors: Bevilacqua G. , Garzelli M. V. , Kardos A. , Toth L. 
Published: April 2022

Abstract
The hadroproduction of a W boson in association with a charm quark at the Large Hadron Collider is at the centre of current investigations due to its potential to probe the strangeness content of the proton. In this paper we present an implementation of the W + c production process in the PowHel event generator matched to the PYTHIA8 parton shower approach, allowing to obtain predictions for differential cross-sections with NLO QCD accuracy matched to the accuracy of the Shower Monte Carlo event generator. Effects of non-diagonal CKM matrix elements, finite charm quark mass and off-shell W decays including spin correlations are taken into account. We investigate the production of a leptonically decaying W boson in association with either a charmed meson (W± + D∗∓) or a charmed jet (W± + jc) and compare our predictions with particle-level measurements by the ATLAS and CMS collaborations at $$ \sqrt{s} $$

s

= 7 and 13 TeV. The role of the so-called “opposite sign” and “same sign” contributions to the theoretical cross-sections is presented and discussed, pointing out the importance of including parton shower effects for a reliable estimate of the latter and a faithful comparison with experimental data.
Long-lived sterile neutrinos at Belle II in effective field theory
Authors: Zhou Guanghui , Günther Julian Y. , Wang Zeren Simon , de Vries Jordy , Dreiner Herbi K. 
Published: April 2022

Abstract
Large numbers of τ leptons are produced at Belle II. These could potentially decay into sterile neutrinos that, for the mass range under consideration, are typically long-lived, leading to displaced-vertex signatures. Here, we study a displaced-vertex search in the context of the sterile-neutrino-extended Standard Model Effective Field Theory. The production and decay of the sterile neutrinos can be realized via either the standard active-sterile neutrino mixing or higher-dimensional operators in the effective Lagrangian. We perform Monte-Carlo simulations to estimate the Belle II sensitivities to such interactions. We find that Belle II can probe non-renormalizable dimension-six operators involving a single sterile neutrino up to a few TeV in the new-physics scale.
Spezifika der Lehre in der Gefäßchirurgie im interdisziplinär-chirurgischen Setting
Authors: Barth Udo , Meyer Frank , Halloul Zuhir 
Published: April 2022

Zusammenfassung
Ziel
Es sollen die komplexen Veränderungen in der gefäßchirurgischen Lehre, Gemeinsamkeiten/Unterschiede zur Allgemeinchirurgie, Spezifika der Lehre/Lehrinhalte sowie deren universitäre Voraussetzungen umrissen werden.

Methode
Kompakte narrative Kurzübersicht.

Ergebnisse
Der gefäßchirurgische Anteil an den chirurgischen Vorlesungen im Universitätsklinikum Magdeburg A.ö.R. umfasst 10 akademische Lehrstunden und beinhaltet die Themen: pAVK, Embolie/Thrombose, Gefäßverletzung, Kompartmentsyndrom, Mesenterialischämie, Aorten‑/Aneurysma- und venöse Chirurgie. Damit liegt die hiesige gefäßchirurgische Lehre deutlich über dem Durchschnitt von 6,1 akademischen Lehrstunden in Deutschland. Die Stärke der (gefäß‑)chirurgischen Ausbildung liegt insbesondere darin, dass der Erkenntnisgewinn am Krankenbett anschließend im Operationssaal insbesondere an visuelle Eindrücke mit simultaner Erklärung gekoppelt werden kann. Eine enge Einbindung der/s Studierenden ins Team ist die hohe Kunst, um die Akzeptanz der (Gefäß‑)Chirurgie als Beruf und Berufung zu fördern. Voraussetzung für eine erfolgreiche Lehre ist ein didaktisch kompetenter Lehrender mit fachlicher Expertise, proaktiver Lehreinstellung, Kenntnissen der speziellen Lernziele, des Curriculums, modernen Lehrmethoden und Bewusstsein für die besondere Vorbildfunktion für Studierende. Die berechtigte und zu stärkende klassische Lehre mittels Vorlesung, Seminar, Praktikum und Lehrbuch wird zunehmend durch Nutzung von internetbasierten Lernplattformen, Bibliotheken und Videoportalen ergänzt.

Zusammenfassung
Die gefäßchirurgische Lehre wird sich in den nächsten Jahren multimodal/-medial mit mehr praxisorientierten Anteilen und intensiver Integration der Studierenden in den Klinikalltag verlagern (müssen).
Electrical resistance characteristics of thermally modified wood
Authors: van Blokland Joran , Adamopoulos Stergios 
Published: April 2022

AbstractThis paper presents electrical resistance characteristics of ThermoWood® Thermo-D Norway spruce for wood moisture content measurements below fibre saturation point. Electrical resistance along the grain of small clear wood specimens was measured at various moisture content levels of ~ 4–15% for thermally modified and ~ 5–25% for unmodified spruce. The results show that—similar to unmodified wood—the relationship between wood moisture content and electrical resistance can be well described by a first order polynomial function obtained from simple linear regression. This provides accurate resistance-based predictions of thermally modified wood moisture content. In addition, established temperature corrections derived previously from unmodified wood seem applicable to thermally modified wood.
A DFT study of the tautomerism of 1H-benzo[de]cinnolines and their protonated forms
Authors: Elguero José , Alkorta Ibon 
Published: April 2022

Abstract1H-Benzo[de]cinnolines and 1H-indeno[6,7,1-def]cinnolines have been studied theoretically at the B3LYP/6-311++G(d,p) level in the gas-phase and in water solution (PCM model); gas-phase geometries were used to calculate absolute shieldings (GIAO) that were transformed into chemical shifts using empirical equations. The annular tautomerism of neutral species and of protonated cations have been determined, and the most stable cations coincide with those determined experimentally.
A large-scale comparison of reproduction and recruitment of the stalked barnacle Pollicipes pollicipes across Europe
Authors: Aguión Alba , Cruz Teresa , Acuña José Luis , Broudin Caroline , Castro João J. , Davoult Dominique , Dubert Jesus , Fernandes Joana N. , Geiger Katja J. , Jacinto David , Mateus David , Muñiz Carlota , Nolasco Rita , Perrier Lucile , Queiroga Henrique , Román Salvador , Silva Teresa , Thiébaut Eric , Vázquez Elsa , Macho Gonzalo 
Published: April 2022

AbstractUnderstanding large-scale spatial and temporal patterns of marine populations is a central goal in ecology, which has received renewed attention under climate change. However, few studies explore the large-scale dynamics of populations using standardized protocols and during the same time frames. We studied the phenology and intensity of reproduction and recruitment for the intertidal stalked barnaclePollicipes pollicipesover an European scale and described their potential linkages with environmental variables. This species supports profitable fisheries in the Iberian Peninsula (Spain and Portugal). In Brittany (France), we had observed a significant lower reproductive effort (long non-breeding season, short breeding period in summer) and low values of recruitment intensity. This pattern may be related to the fact that Brittany corresponds to the northern limit of the distribution of this species in continental Europe. On the Iberian Peninsula, the most different region was Galicia (Spain), with Asturias (Spain) and SW Portugal being more similar. In Galicia, we have observed a contradictory pattern characterized by the absence of a non-breeding period and by a shorter recruitment season than observed in other Iberian regions. Our results suggest that air temperature, SST and chlorophyll-a might be related to the variability in reproduction and recruitment patterns ofP. pollicipes. Moreover, spring and early summer upwelling in SW Portugal and Galicia might be inhibiting recruitment in this period. At the northern limit, the expected increase in performance under climate change might facilitate the recovery of populations after exploitation, increasing the resilience of the resource to fishing pressure.
Tissue-resident memory T cells in the kidney
Authors: Asada Nariaki , Ginsberg Pauline , Gagliani Nicola , Mittrücker Hans-Willi , Panzer Ulf 
Published: April 2022

AbstractThe identification of tissue-resident memory T cells (TRMcells) has significantly improved our understanding of immunity. In the last decade, studies have demonstrated that TRMcells are induced after an acute T-cell response, remain in peripheral organs for several years, and contribute to both an efficient host defense and autoimmune disease. TRMcells are found in the kidneys of healthy individuals and patients with various kidney diseases. A better understanding of these cells and their therapeutic targeting might provide new treatment options for infections, autoimmune diseases, graft rejection, and cancer. In this review, we address the definition, phenotype, and developmental mechanisms of TRMcells. Then, we further discuss the current understanding of TRMcells in kidney diseases, such as infection, autoimmune disease, cancer, and graft rejection after transplantation.
Association of pulmonary vein isolation and major cardiovascular events in patients with atrial fibrillation
Authors: Girod Marc , Coslovsky Michael , Aeschbacher Stefanie , Sticherling Christian , Reichlin Tobias , Roten Laurent , Rodondi Nicolas , Ammann Peter , Auricchio Angelo , Moschovitis Giorgio , Kobza Richard , Badertscher Patrick , Knecht Sven , Krisai Philipp , Marugg Andrea , Aebersold Helena , Hennings Elisa , Serra-Burriel Miquel , Schwenkglenks Matthias , Zuern Christine S. , Bonati Leo H , Conen David , Osswald Stefan , Kühne Michael 
Published: April 2022

Abstract
Background
Patients with atrial fibrillation (AF) face an increased risk of adverse cardiovascular events. Evidence suggests that early rhythm control including AF ablation may reduce this risk.

Methods
To compare the risks for cardiovascular events in AF patients with and without pulmonary vein isolation (PVI), we analysed data from two prospective cohort studies in Switzerland (n = 3968). A total of 325 patients who had undergone PVI during a 1-year observational period were assigned to the PVI group. Using coarsened exact matching, 2193 patients were assigned to the non-PVI group. Outcomes were all-cause mortality, hospital admission for acute heart failure, a composite of stroke, transient ischemic attack and systemic embolism (Stroke/TIA/SE), myocardial infarction (MI), and bleedings. We calculated multivariable adjusted Cox proportional-hazards models.

Results
Overall, 2518 patients were included, median age was 66 years [IQR 61.0, 71.0], 25.8% were female. After a median follow-up time of 3.9 years, fewer patients in the PVI group died from any cause (incidence per 100 patient-years 0.64 versus 1.87, HR 0.39, 95%CI 0.19–0.79, p = 0.009) or were admitted to hospital for acute heart failure (incidence per 100 patient-years 0.52 versus 1.72, HR 0.44, 95%CI 0.21–0.95, p = 0.035). There was no significant association between PVI and Stroke/TIA/SE (HR 0.94, 95%CI 0.52–1.69, p = 0.80), MI (HR 0.43, 95%CI 0.11–1.63, p = 0.20) or bleeding (HR 0.75, 95% CI 0.50–1.12, p = 0.20).

Conclusions
In our matched comparison, patients in the PVI group had a lower incidence rate of all-cause mortality and hospital admission for acute heart failure compared to the non-PVI group.

ClinicalTrials.gov Identifier
NCT02105844, April 7th 2014.

Graphical abstract
Real-world outcomes of teriflunomide in relapsing–remitting multiple sclerosis: a prospective cohort study
Authors: Zhang Yao , Yin Hexiang , Zhang Dingding , Xu Yan , Peng Bin , Cui Liying 
Published: April 2022

Abstract
Objectives
To explore efficacy, risk factors, safety, and persistence of teriflunomide in relapsing–remitting multiple sclerosis (RRMS) cohort.

Methods
This prospective, observational cohort study included 217 consecutive teriflunomide treated RRMS patients, 192 of which with at least 3-month persistence on teriflunomide were included in effectiveness and risk factor analyses. Multivariate Cox proportional regression analysis was performed to identify factors associated with failure of no evidence of disease activity (NEDA) 3.

Results
At baseline 82% patients were treatment naïve while 18.0% interferon-β1b treated patients had stopped treatments for more than 1 year. After treatment, 79.0% patients achieved NEDA 3 at 12-month, mean annualized relapse rate (ARR) reduced significantly (0.79 ± 0.80 vs 0.16 ± 0.70; P < 0.001), and mean expanded disability status score (EDSS) remained stable (1.40 ± 1.67 vs 1.56 ± 1.88; P > 0.05). Male sex (hazard ratio [HR] 1.856; 95% confidence interval [CI] 1.118–3.082, P < 0.05), baseline EDSS score ≥ 4 (HR 2.682; 95% CI 1.375–5.231, P < 0.01), and frequent relapses before treatment (HR 3.056; 95% CI 1.737–5.377, P < 0.01) were independent factors significantly associated with failure of NEDA 3. The most frequent adverse events (AEs) were hair thinning, alanine aminotransferase (ALT) elevation, and leukopenia, the latter two most commonly lead to teriflunomide discontinuation during the first 3 months. Persistence rates at 6, 12, and 24 months after teriflunomide initiation were 86.9%, 72.4%, and 52.8%, respectively.

Conclusions
Our results support efficacy and tolerability of teriflunomide for treatment-naïve RRMS patients in real-world practice. Female patients, patients with less relapses and less disability before treatment are most likely to benefit from teriflunomide treatment.
Acute phase of Kawasaki disease: a review of national guideline recommendations
Authors: Scherler Laura , Haas Nikolaus A. , Tengler Anja , Pattathu Joseph , Mandilaras Guido , Jakob André 
Published: April 2022

AbstractKey aspects of the medical management of Kawasaki disease (KD) are not yet supported by a high evidence level, thus making room for individual recommendations. We performed a structured comparison of existing international KD guidelines to analyze potential differences in the implementation of evidence-based KD recommendations regarding diagnosis and therapy. To identify country-specific guidelines, we took a multilateral approach including a comprehensive PubMed literature, online research, and directly contacting national pediatric associations. We then ran a structured guidelines’ analysis and evaluated the diagnostic and therapeutic differences in the context of evidence-based medicine. In this structured guideline analysis, we identified nine national and one European guidelines. According to them all, the diagnosis of KD still relies on its clinical presentation with no reliable biomarker recommended. First-line treatment consistently involves only intravenous immunoglobulin (IVIG) therapy. Recommendations in terms of acetylsalicylic acid, corticosteroids, and additional therapeutic options vary considerably.Conclusion: According to all guidelines, KD is diagnosed clinically with some variance in defining incomplete KD and being a non-responder to treatment. First-line treatment consistently includes IVIG. Recommendations for additional therapeutic strategies are more heterogeneous.

What is Known:• The diagnosis of KD relies on the clinical presentation, entailing challenges in timely diagnosis.• Other treatment options then IVIG are not supported by a high evidence level, making room for individual recommendations.

What is New:• Definition of incomplete KD and being non-responsive to an initial treatment vary to some extent between the national guidelines.• Only IVIG is consistently proposed throughout all guidelines, further therapeutic recommendations vary between the national recommendations.
Erinnertes elterliches Erziehungsverhalten und psychische Erkrankung – zur Bedeutung der Erste-Person-Perspektive
Authors: Steinmair Dagmar , Schwigon Dieter , Masic Namik , Löffler-Stastka Henriette 
Published: April 2022

ZusammenfassungEin Einflussfaktor auf psychische Gesundheit im Erwachsenenalter ist die Erfahrung in Beziehungen im Kindesalter, wobei es vor allem auf die erlebte Wirklichkeit ankommt. Nicht immer ist aber der Zusammenhang so eindeutig wie im Falle einer frühen Traumatisierung, wie sie in der Fallvignette dieses Artikels dargestellt wird. Die um die subjektiven Erlebensqualitäten erweiterte, multifaktorielle Genese psychischer Störung öffnet Forschungsfragen.
Validation of a short Italian version of the Barratt Impulsiveness Scale (BIS-15) in non-clinical subjects: psychometric properties and normative data
Authors: Maggi Gianpaolo , Altieri Manuela , Ilardi Ciro Rosario , Santangelo Gabriella 
Published: April 2022

Abstract
Introduction
The Barratt Impulsiveness Scale (BIS) is a questionnaire employed to measure impulsivity, which is associated with risky behaviors and mental disorders. We aimed to assess the psychometric properties of the BIS in the Italian general population and provide normative data for clinical use.

Materials and methods
A cross-sectional survey methodology was employed to collect data. Then, 534 participants of different ages and educational levels completed the BIS, PHQ-9, GAD-7, and S-UPPS-P. We designed an ad hoc data-driven outcome checklist to identify which items deserved to be retained. Furthermore, internal consistency, convergent and divergent validity, and factorial structure were evaluated. A regression-based procedure was used to explore the influence of demographic variables on the BIS score and to provide adjusting factors and a sensitive cutoff.

Results
Item analysis suggested removing 15 items. Consequently, we tested the psychometric properties of a shorter version of the BIS (BIS-15). IRT test information functions indicated an almost identical measurement precision of the BIS-15 as compared to the original BIS. The BIS-15 demonstrated reliable internal consistency and good convergent and divergent validity. The PCA revealed a four-factor solution: “pure impulsivity,” “planning and thinking,” “lack of attention and concentration,” and “impulsive buying.” A significant effect of sex and years of education was found. Norms for the adjustment of raw scores were provided (cutoff = 37.39).

Conclusions
The BIS-15 showed almost identical psychometric properties as compared with the original scale, reducing the administration time. Our norms may allow identifying individuals with impulsivity of clinical interest.
Comparison between a phenomenological approach and a morphoelasticity approach regarding the displacement of extracellular matrix
Authors: Peng Q. , Gorter W. S. , Vermolen F. J. 
Published: April 2022

AbstractPlastic (permanent) deformations were earlier, modeled by a phenomenological model in Peng and Vermolen (Biomech Model Mechanobiol 19(6):2525–2551, 2020). In this manusctipt, we consider a more physics-based formulation that is based on morphoelasticity. We firstly introduce the morphoelasticity approach and investigate the impact of various input variables on the output parameters by sensitivity analysis. A comparison of both model formulations shows that both models give similar computational results. Furthermore, we carry out Monte Carlo simulations of the skin contraction model containing the morphoelasticity approach. Most statistical correlations from the two models are similar, however, the impact of the collagen density on the severeness of contraction is larger for the morphoelasticity model than for the phenomenological model.
How do carious root lesions develop after the end of professional preventive measures?—Preliminary findings of a randomized clinical trial
Authors: Kreher Deborah , Korn Viktoria , Meißner Thomas , Haak Rainer , Schmalz Gerhard , Ziebolz Dirk 
Published: April 2022

AbstractAim of this randomized clinical trial was to assess the development of root caries lesions with and without (adjuvant) professional prevention treatment over 24 months. 20 participants with two or three non-cavitated root carious lesions were included (n = 52), whereby lesions were randomly assigned to one out of three groups depending on varnish application (CF: Cervitec F [n = 20], P: placebo [n = 20], DP: Duraphate [n = 12]). All lesions were assessed by quantitative light-induced fluorescence (QLF; QRayCam); following outcome parameters were analyzed: fluorescence loss (ΔF %), lesion volume (ΔQ %µm2) and bacterial activity (ΔR %). Professional tooth cleaning and adjuvant varnish application were performed at baseline, after 3, 6, and 9 months. A follow-up examination was performed 1 year after preventive care with varnish application 24 months after baseline. ∆F showed a significant time effect in CF (p = 0.03), which was not confirmed in post hoc analysis (p > 0.05). For P and DP, no time effect was detected (p > 0.05). ∆Q was significantly higher 12 months after baseline in CF (p = 0.02). In P, a significant time effect occurred (p = 0.01), without significant results in post hoc testing. ∆R showed higher values at baseline vs. 12 months in CF (p = 0.03) and 24 months compared to 12 months in DP (p = 0.02). Professional preventive treatment inhibited the progression of root caries lesions beyond their termination for 12 months, irrespective of an adjunctive varnish application. Preventive measures have a long-term effect on root carious lesions, even 1 year after their termination.