bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical activity enhances the improvement of body mass index and metabolism by inulin: a multicenter randomized placebo-controlled trial performed in obese individuals
Authors: Rodriguez Julie , Neyrinck Audrey M. , Van Kerckhoven Maxime , Gianfrancesco Marco A. , Renguet Edith , Bertrand Luc , Cani Patrice D. , Lanthier Nicolas , Cnop Miriam , Paquot Nicolas , Thissen Jean-Paul , Bindels Laure B. , Delzenne Nathalie M. 
Published: March 2022

AbstractBackgroundDietary interventions targeting the gut microbiota have been proposed as innovative strategies to improve obesity-associated metabolic disorders. Increasing physical activity (PA) is considered as a key behavioral change for improving health. We have tested the hypothesis that changing the PA status during a nutritional intervention based on prebiotic supplementation can alter or even change the metabolic response to the prebiotic. We confirm in obese subjects and in high-fat diet fed mice that performing PA in parallel to a prebiotic supplementation is necessary to observe metabolic improvements upon inulin.MethodsA randomized, single-blinded, multicentric, placebo-controlled trial was conducted in obese participants who received 16 g/day native inulin versus maltodextrin, coupled to dietary advice to consume inulin-rich versus -poor vegetables for 3 months, respectively, in addition to dietary caloric restriction. Primary outcomes concern the changes on the gut microbiota composition, and secondary outcomes are related to the measures of anthropometric and metabolic parameters, as well as the evaluation of PA. Among the 106 patients who completed the study, 61 patients filled a questionnaire for PA before and after intervention (placebo:n = 31, prebiotic:n = 30). Except the dietitian (who provided dietary advices and recipes book), all participants and research staff were blinded to the treatments and no advices related to PA were given to participants in order to change their habits. In parallel, a preclinical study was designed combining both inulin supplementation and voluntary exercise in a model of diet-induced obesity in mice.ResultsObese subjects who increased PA during a 3 months intervention with inulin-enriched diet exhibited several clinical improvements such as reduced BMI (− 1.6 kg/m2), decreased liver enzymes and plasma cholesterol, and improved glucose tolerance. Interestingly, the regulations ofBifidobacterium, Dialister, andCatenibacteriumgenera by inulin were only significant when participants exercised more. In obese mice, we highlighted a greater gut fermentation of inulin and improved glucose homeostasis when PA is combined with prebiotics.ConclusionWe conclude that PA level is an important determinant of the success of a dietary intervention targeting the gut microbiota.Trial registrationClinicalTrials.gov,NCT03852069(February 22, 2019 retrospectively registered).
Impact of perioperative blood transfusions on postoperative renal function and survival after resection of colorectal liver metastases
Authors: Rodieck Wiebke , Hallensleben Michael , Robert Julia , Beetz Oliver , Grannas Gerrit , Cammann Sebastian , Oldhafer Felix , Klempnauer Juergen , Vondran Florian W. R. , Kulik Ulf 
Published: March 2022

Abstract
Background and aims
Recent studies focusing on thoracic surgery suggest postoperative kidney injury depending on the amount of perioperative blood transfusions. Data investigating similar effects after resection of colorectal liver metastases (CRLM) are not available. Aim of this study was therefore to evaluate the influence of perioperative blood transfusions on postoperative renal function and survival after resection of CRLM.

Methods
Seven hundred twenty-seven cases of liver resection for CRLM were retrospectively analyzed. Renal function was measured via estimated glomerular filtration rate (eGFR) and a postoperative decline of ≥ 10% was considered substantial. Potential influences on postoperative kidney function were assessed using univariable and multivariable logistic regression analyses. Cox-regression analyses were performed to estimate the impact on overall survival (OS).

Results
Preoperative impaired kidney function (p = 0.001, OR 2.477) and transfusion of > 2 units of packed red blood cells (PRBC) (p = 0.046; OR 1.638) were independently associated with an increased risk for ≥ 10% loss of renal function. Neither a pre-existing renal impairment, nor the additional loss of renal function were associated with reduced survival. Chemotherapies in the context of primary colorectal cancer treatment (p = 0.002), age > 70 years at liver resection (p = 0.005), number (p = 0.001), and size of metastases > 50 mm (p = 0.018), duration of resection > 120 min (p = 0.006) and transfusions of > 2 units of PRBC (p = 0.039) showed a negative independent influence on OS.

Conclusion
The results demonstrate a negative impact of perioperative blood transfusions on the postoperative renal function and OS. Hence, efforts to reduce blood transfusions should be intensified.
Alzheimer’s disease: history, ethics and medical humanities in the context of assisted suicide
Authors: Braun Birgit , Demling Joachim , Loew Thomas Horst 
Published: March 2022

Abstract
Introduction
Dementia diseases, especially Alzheimer’s disease (AD), are of considerable importance in terms of social policy and health economics. Moreover, against the background of the current Karlsruhe judgement on the legalisation of assisted suicide, there are also questions to be asked about medical humanities in AD.

Methodology
Relevant literature on complementary forms of therapy and prognosis was included and discussed.

Results
Creative sociotherapeutic approaches (art, music, dance) and validating psychotherapeutic approaches show promise for suitability and efficiency in the treatment of dementia, but in some cases still need to be scientifically tested. Biomarker-based early diagnosis of dementia diseases is increasingly becoming a subject of debate against the background of the Karlsruhe ruling.

Discussion
Needs-oriented and resource-enhancing approaches can make a significant contribution to improving the quality of life of people with dementia. The discussion on the issue of “assisted suicide” should include questions of the dignity and value of a life with dementia.

Outlook
The integrative dementia therapy model can be complemented by a religion- and spirituality-based approach. Appropriate forms of psychotherapy should be scientifically evaluated.
Confusing Context with Character: Correspondence Bias in Economic Interactions
Authors: Han Yi , Liu Yiming , Loewenstein George 
Published: March 2022

When drawing inferences about a person’s personal characteristics from the person’s actions, “correspondence bias” is the tendency to overestimate the influence of those characteristics and underestimate the influence of situational factors, such as incentives the individual faces. We build a simple framework to formalize correspondence bias and test its predictions in an online experiment. Consistent with correspondence bias, subjects are, on average, willing to pay to receive the dictator-game givings of an individual with whom they are randomly assigned to play a game that encourages cooperation rather than one with whom they play a game that encourages selfish behavior. We show, further, that experiencing both games oneself, as opposed to playing one and observing the other, reduces the bias, and receiving information about how each of the players behaved in both games eliminates it. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: Y. Liu acknowledges financial support from the Einstein Foundation [Grant EVF-2018-426]. Supplemental Material: Data files are available at https://doi.org/10.1287/mnsc.2022.4384 .
Acceptability of unsupervised peer-based distribution of HIV oral self-testing for the hard-to-reach in rural KwaZulu Natal, South Africa: Results from a demonstration study
Authors: Kitenge Marcel K. , Laxmeshwar Chinmay , Bermudez Aza Elkin , Ford-Kamara Ellie , Van Cutsem Gilles , Gcwensa Ntombi , Casas Esther C. , Hlophe Khanyo , Isaakidis Petros , Ohler Liesbet 
Published: March 2022

Background
Innovative models to distribute oral HIV self-tests (HIVST) provide an opportunity to increase access to HIV testing, especially for hard-to-reach populations. This study aimed to describe the acceptability of unsupervised peer-distribution of HIVST as a method to scale-up HIV testing.

Methods
In this study, lay counsellors or community health workers provided HIVST kits to primary recipients (PRs) for distribution to their sexual partners, anyone in their social network (termed secondary recipients) or for self-testing, from September 2018 to March 2020. The study was conducted in Eshowe and Mbongolwane areas in KwaZulu-Natal, South Africa. A structured questionnaire was administered during the recruitment and passive follow-up, when people came for confirmatory HIV testing. Electronic records were retrospectively examined to determine initiation of antiretroviral treatment (ART) for all HIVST users and non-users.

Results
Among 36,708 people approached to be primary recipients, 9,891 (26.9%) accepted; 31,341 HIVST kits were distributed with a median of three (IQR: 2–4) per peer. PRs were predominately recruited at primary health clinics (PHCs). However, acceptability of HIVST was thrice as high at community-based testing sites compared to PHCs (64.5% vs. 21.0%; p<0.001). During the study period, 34,715 adults were tested for HIV at both PHCs and community-based testing sites; of these, 1,089 individuals reported HIVST use. Among HIVST users, 893 (82.0%) returned to the clinic for confirmatory testing after testing negative on HIVST; 196 (17.9%) were confirmed HIV positive following a positive HIVST. After excluding 36/196 (18.4%) participants for whom clinical records could not be found in electronic register and 25/160 (15.6%) who were already on ART before receiving HIVST, 129/135 (95.5%) initiated ART, whereas 2,362/2685 (88%) of HIV positive HIVST non-users-initiated ART.

Conclusion
Unsupervised peer-distribution of HIVST was feasible and acceptable, with more than 25% accepting to be peer-distributors. Acceptability of HIVST was thrice as high in community sites compared to clinics.
Prilog opusu slikara Bazija Ivankovića: portreti jedrenjaka Prima Donna i parobroda Vera ex Vercingetorex
Authors: Brguljan Željko 
Published: March 2022

Nakon uvodnog dijela o pojavi portretnog slikarstva brodova i važnijim portretistima brodova u lukama Sredozemlja, posebno onima koji su slikali brodove u vlasništvu ili pod zapovjedništvom kapetana iz pomorskih središta istočne jadranske obale, od Trsta do Kotora, članak se bavi osobom i djelom Bazija Ivankovića (1815. – 1898.), pomorskog kapetana podrijetlom s južnojadranske obale, koji u drugoj polovici 19. st. postaje najplodniji tršćanski slikar brodova. Ustrajnim istraživanjem registrirali smo 276 slikareva rada, likovni opus koji dodatno rasvjetljava i osobito ilustrira prošlost pomorstva istočne jadranske obale, ali i povijest parobrodarskog društva Austrijski Lloyd iz Trsta. Ovom prilikom katalogu Ivankovićevih djela pridružujemo portrete jedrenjaka Prima Donna i parobroda Vera (ex Vercingetorex). Oba broda nastala su u slikarevoj poodmakloj dobi, a očigledna razlika u prenijetoj atmosferi (prva u smirenom, a druga u živom ozračju) potakla nas je na likovnu analizu, ali i istraživanja u pomorsko-povijesnom kontekstu, uvijek nužno kod slikarstva brodova. Stoga smo dvije, likovno analizirane, Ivankovićeve slike opravdano obogatili otkrivenim podacima o naslikanim brodovima, te tako uzbudljivi likovni prikazi dobivaju i zanimljiv plovidbeni životopis.
El Método Prudencial como base fundamental para la planeación estratégica del direccionamiento académico
Authors: González Gil Eduardo , Fonseca Ortiz Lina María 
Published: March 2022

En clave del direccionamiento académico de la Universidad Santo Tomás (USTA) se contempla, desde la Vicerrectoría Académica General, la planeación estratégica en el marco del método prudencial de Tomás Aquino - “ver, juzgar y actuar” (S. Th. 2-2 q.47, a. 8 s) -, con el objetivo de apalancar de forma adecuada el desarrollo de sus funciones universitarias y garantizar el cumplimiento de su objetivo misional —la formación integral—, el cual se constituye en compromiso irrestricto institucional. En este sentido, es comprensible plantearse la pregunta de ¿cómo articular el método prudencial de Tomás de Aquino con la planeación estratégica? Para ello, conviene reconocer el significado de la prudencia.
Apresentação
Authors: Scliar-Cabral Leonor , Pinto Maria da Graça , Zasyekina Larysa 
Published: March 2022

The special volume of the journal Signo, 88(47), 2022 publishes the submitted, evaluated, accepted and reviewed articles, product of the communications and conferences presented at the Online 12th ISAPL International Congress "New perspectives in psycholinguistic research: language, culture, technologies", June 3-5, 2021.
Twenty-two authors represent nine countries (Belgium, Brazil, France, Georgia, Poland, Portugal, Romania, Russia and Ukraine), since, of the seventeen papers selected, some were written by more than one author. Brazilian authors constitute the largest number (eight), which is understandable, since the current ISAPL President and Secretary-Treasurer are Brazilians.
Therapeutic evaluation of various modalities in keloid
Authors: Gamit Hemangini H. , Karia Umesh K. , Shah Bela J. 
Published: March 2022

Keloid is deregulated fibroproliferative growth in response to tissue injury. Keloids are known for their stubborn nature and present as therapeutic challenges in practice. Aim of our study is to evaluate various treatment modalities for search of treatment which stand out with maximum efficacy and least side effect. 120 patients with presternal keloid (female and male, aged 18-60 years) were recruited to receive one of the five treatment methods which were(1) Cryotherapy,(2) Cryotherapy and intralesional Triamcinolone acetonide,(3) Cryotherapy and intralesional 5- Fluorouracil(4) Cryotherapy and combination of Intralesional Triamcinolone acetonide with 5- Fluorouracil(5) Cryotherapy and Intralesional Triamcinolone acetonide combined with Silicone gel sheet application in each group respectively. Evaluation done by the Patient and Observer Scar Assessment Scale (POSAS) score at every 3 week till 6 months. Patients with significant improvement (&#62; 50% reduction in POSAS) were 42%, 75%, 75%, 85%, and 90% in each 5 group respectively. Side effects like Hypopigmentation and Skin atrophy were significantly much frequent in group 2 while skin ulceration and pain were common with group 3. Group 1 showed maximum recurrence of lesion while no recurrence was seen in group-2 and 5 even after 3 month of post treatment. Among nonsurgical treatment modalities, Cryotherapy along with intralesional medication like triamcinolone acetonide and 5 fluorouracil and adjuvant therapy like silicone gel sheet are promising, inexpensive and an effective OPD based treatment that provide good alternative for keloid treatment in comparison to surgical procedures.
Comparison of efficacy of natural antioxidants on the adhesive bond strength of NaOCL treated dentin
Authors: Pavankumar O , Paturu Prathibha 
Published: March 2022

To compare efficacy of Natural collagen crosslinkers on the adhesive bond strength of Naocl treated pulp chamber dentin. A total of 50 Mandibular molars are randomly divided into four groups according to the solution used. Group I: Negative Control: No treatment.Then, specimens are bonded with self-etch adhesive followed by composite restoration. These specimens are sectioned to produce sticks which are subjected to bond strength test. Grape Seed Extract, Propolis and Vitamin E increased shear bond strength of the composite restoration to NaOCl treated dentin.
Análise da cobertura vacinal em menores de cinco anos em um estado fronteiriço da Amazônia
Authors: Zambonin Fernanda , Bezerra Lima Karen Ludimylla , Costa de Sousa Priscilla de Araújo , Muniz Thais Renata , Voges Caldart Raquel , Da Costa Maciel Jackeline , Camargo Calvino 
Published: March 2022

Objetivou-se realizar uma análise temporal da cobertura vacinal em menores de cinco anos em um estado fronteiriço da região amazônica. Trata-se de um estudo quantitativo, epidemiológico, de série histórica, por meio de dados do Departamento de Informática do Sistema Único de Saúde (DATASUS) sobre a cobertura vacinal no estado de Roraima entre os anos de 2013 e 2017. De maneira geral, a cobertura vacinal mostrou-se instável no período analisado, apontando para um aumento nos anos de 2013 a 2015 e uma tendência de redução entre o período de 2015 a 2017 nas três esferas avaliadas (Brasil, Região Norte e Roraima). Todavia, o estado de Roraima apresentou indicadores acima da média nacional a partir de 2015. Com relação aos imunobiológicos, somente a BCG alcançou a meta preconizada em toda série histórica. Diante disso, verificou-se heterogeneidade nas coberturas quando avaliados os imunobiológicos isoladamente e houve uma redução geral na cobertura vacinal, apontando a necessidade de criar estratégias eficazes para direcionar as ações em saúde de maneira a controlar ou erradicar as doenças imunopreviníveis.
A Interprofissionalidade nos Cursos de Enfermagem de Instituições de Ensino Superior Públicas da Região Sul do Brasil
Authors: Cassaro Bernarda Cesira , Cipolato Franklin de Almeida , Pinheiro Larissa Jaine , Tombini Larissa Hermes Thomas , Fonsêca Graciela 
Published: March 2022

Objetivo: Identificar componentes curriculares ou disciplinas interprofissionais nos Projetos Pedagógicos Curriculares dos cursos de graduação em enfermagem das Instituições de Ensino Superior públicas localizadas na região Sul do Brasil. Método: Trata-se de um estudo qualitativo, de caráter exploratório, norteado por análise documental, cujo corpus foram os PPC dos cursos de graduação em Enfermagem. Resultados: Foram identificados 18 cursos de graduação em enfermagem e somente um deles apresentava um componente curricular eletivo que inclui diretamente interprofissionalidade em sua ementa, outros dois cursos abordam a temática em alguns componentes curriculares. Na análise da disciplina ímpar que dá ênfase a interprofissionalidade, frisa-se a eletividade e o fato de não exigir pré-requisitos. Conclusão: A Educação Interprofissional pode ser considerada uma ferramenta essencial para formar e preparar profissionais de saúde aptos a enfrentar as dificuldades e fragilidades dos serviços, de modo a intervir com maior grau de resolubilidade nos problemas de saúde da população.
Features of Power Relations in the Digital Age
Authors: Ignatieva Olga 
Published: March 2022

The rapid development of information and communication technologies at the end of the XX century and the first quarter of the XXI century led to the formation first a networked and then a digital society, which went beyond the national borders of the state. Power relations in the nation-state have also undergone changes. The position of national elites became less stable, as well as the legitimacy of their decisions, due to the dominance of transnational structures based on the capabilities of telecommunications networks. Power has moved beyond national borders and is concentrated in the hands of those who dominate global networks and own global digital platforms. The notion of industrial capitalism has been replaced by the notion of transnational imperialism. However, the power in social networks is held not only by nation-states, but also by social movements, which are considered, in M. Castells&#x27; terminology, as counter-power. The purpose of this research is to identify the characteristics of power relations in the digital society, both nationally and globally.
Editorial
Authors: Coutinho Luciana Cristina Salvatti 
Published: March 2022

Num contexto de incertezas, perda de direitos sociais, avanço das privatizações, aumento das desigualdades sociais e educacionais, continuidade da Pandemia da COVID19 que tem provocado a morte de milhares de pessoas, manter o trabalho acadêmico e de divulgação científica comprometida com a transformação social são expressões de resistência e de luta. Nesse cenário, a Revista Histedbr On-line publica em 2021 o volume 21, contando com 54 artigo e 5 resenhas, abordando temáticas e perspectivas analíticas diversas, marca da história desse periódico. A vinculação institucional dos(as) autores(as) dos manuscritos publicados nesse volume é diversa, tanto nacional quanto internacionalmente: UNIOESTE, Rede Estadual de Ensino do Paraná, Prefeitura Municipal de Chopinzinho, Unicentro, UFOPA, UFMS, Universidade Rovuma (Moçambique), UFAM, UFPA, Prefeitura de Altamira/PA, UFSM, IFRS, IFFar, PUC-Goiás, UFT, UFF, UFS, UNIR, Rede Estadual de Ensino de Rondônia, UFV, UPE, Secretaria Municipal de Educação de São Paulo, IF Sudeste MG, Universidade La Salle, UFSCar, UECE, UFPB, SDR Bahia, UESB, CEN, IFG, UFC, CEFET-MG, UEPG, UFES, PUC-PR, UFU, INSS, UTFPR, UFRN, IFPR, UEMG, Rede Municipal de Educação de Caetité/BA, Câmara Federal, UNEB, UNISUL, Prefeitura Municipal de Casemiro de Abreu, UNIRIO, USP, UEMS, Secretaria de Estado de Educação de Mato Grosso do Sul, Secretaria Estadual do Rio Grande do Sul, Unicamp, IFRO, UERJ, UFRRJ, UnB, Secretaria de Estado de Educação do Distrito Federal, UNESPAR, Secretaria de Educação do Maranhão, UNESP, Universidad Nacional de La Plata (Argentina), Universidad de Oriente (Venezuela), IFSP, Universidad de Santiago (Chile), Universidad de Santiago de Compostela (Espanha), Universidad Nacional del Litoral (Argentina).
Pendidikan Konservasi Melalui Budaya Patorani Berdasarkan Sudut Pandang Ilmu Geografi
Authors: Hasriyanti  
Published: March 2022

Abstrak: Konservasi sumber daya alam hayati dan ekosistemnya berkaitan erat dengan tercapainya sasaran yakni menjamin terpeliharanya proses ekologis yang menunjang sistem penyangga kehidupan bagi kelangsungan pembangunan dan kesejahteraan manusia. Penelitian ini menggunakan metode deskriptif kualitatif dengan pendekatan etnografi. Pengumpulan data melalui observasi, wawancara dan tinjauan literatur dan dokumen. Data dianalisis melalui proses reduksi data, display, dan verifikasi data. Hasil penelitian menunjukkan bahwa bentuk konservasi nelayan patorani yakni bentuk konservasi melalui pengetahuan, konservasi melalui alat tangkap, konservasi melalui teknik penangkapan, konservasi melalui ritual keagamaan dan kepercayaan, dan konservasi melalui kasipalli (pantangan). Nelayan patorani tidak lagi sepenuhnya dikontrol oleh lingkungan, tetapi mereka berperan besar menentukan bentuk kegiatan di lingkungan laut (geographical possibilism and probabilism) yang kemudia dikenal dengan pendekatan ekologi (ecological approach). Pendekatan tersebut tepat dalam mengkaji tentang konservasi sumberdaya perikanan di Kecamatan Galesong.
Kata kunci: pendidikan konservasi, budaya patorani, sudut pandang geografi
Abstract: Conservation of natural resources and ecosystems are closely related with the achievement of the target is to ensure the preservation ecological processes which support life support systems for sustainable development and human well-being. This study used descriptive qualitative method with an ethnographic approach. The collection of data are observation, interviews and review of the literature as well as documents. Data were analyzed through the process of data reduction, data display, and data verification. Results of the study showed that the form of conservation fishing patorani namely the nature conservation through knowledge, through the conservation of fishing gear, conservation through fishing techniques, conservation through religious rituals and beliefs, and conservation through kasipalli (abstinence). Fishermen patorani no longer fully controlled by the environment, but they play a major role determining the shape of activities in the marine environment (geographical possibilism and probabilism) later known as the ecological approach (ecological approach). The approach was right in assessing conservation fishery resources in District Galesong.
Keywords: education of conservation, patorani’s culture, viewpoint geography