bluuebunny/crossref_metadata_2025_split huggingface dataset:
PressPurt: network sensitivity to press perturbations under interaction uncertainty
Authors: Koslicki David , Gibbon Dana , Novak Mark 
Published: February 2022

While the use of networks to understand how complex systems respond to perturbations is pervasive across scientific disciplines, the uncertainty associated with estimates of pairwise interaction strengths (edge weights) remains rarely considered. Mischaracterizations of interaction strength can lead to qualitatively incorrect predictions regarding system responses as perturbations propagate through often counteracting direct and indirect effects. Here, we introduce PressPurt, a computational package for identifying the interactions whose strengths must be estimated most accurately in order to produce robust predictions of a network's response to press perturbations. The package provides methods for calculating and visualizing these edge-specific sensitivities (tolerances) when uncertainty is associated to one or more edges according to a variety of different error distributions. The software requires the network to be represented as a numerical (quantitative or qualitative) Jacobian matrix evaluated at stable equilibrium. PressPurt is open source under the MIT license and is available as both a Python package and an R package hosted at https://github.com/dkoslicki/PressPurt and on the CRAN repository https://CRAN.R-project.org/package=PressPurt.
Effect of Aloe vera extract in post-burn skin repair in rats
Authors: Aulia Lusiana , Pane Yunita Sari 
Published: February 2022

Background: Burn injury is a global health problem that is most often caused by heat. Burn injury can cause high morbidity and mortality and requires high cost. Therefore, the use of plants as herbal medicine has the potential to be developed in Indonesia. Aloe vera contains various active ingredients that help the wound healing process, such as glucomannan and acemannan which have the effects on the proliferation of macrophages, and fibroblasts, and re-epithelialization. This study aimed to determine the effect of Aloe vera extract in repairing post-burn skin in rats that was analyzed from the number of macrophages and fibroblasts, and epidermal thickness. Methods: This is an experimental study with a posttest-only control group design using 54 Rattus norvegicus Wistar strain rats. The sampling method was simple random sampling consisting of 3 groups, i.e., I. standard group, which were normal rats; II. negative control group, which were given second-degree burns and treated with gel base (without Aloe vera extract); III. treatment groups, which were given second-degree burns and treated with Aloe vera extract gel. Each group was subdivided into three smaller groups (n = 6) according to the time the lesions were evaluated. Skin tissue samplings were carried out on day 3, 14, and 21 after injury to observe the number of macrophages and fibroblasts, and epidermal thickness. Results: There were significant differences in the mean number of macrophages, number of fibroblasts, and epidermal thickness in all groups (p<0.05). Conclusion: Aloe vera extract gel could accelerate the healing process of burns in rats.
Comparative study of the effect on the neuroendocrine-immune complex and metabolism of drinking monotherapy with Naftussya water and therapy supplemented with “Myroslava” and “Khrystyna” mineral waters
Authors: Hrytsak Myroslava , Popovych Dariya , Badiuk Nataliya , Hrytsan Ivanna , Żukow Xawery 
Published: February 2022

Background. Earlier in an experiment on rats, we showed that the newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have neuroendocrine and metabolic effects significantly different from daily water. Adhering to the principle "From experiment to clinic", we continued research in this direction with the participation of patients of the resort. Materials and Methods. The object of clinical-physiological observation were 34 men aged 23-70 years, who underwent rehabilitation treatment of chronic cholecystitis and pyelonephritis in remission in the Truskavets resort. The examination was performed twice, before and after a 7-10-day course of balneotherapy. All patients received bioactive water Naftussya, however, 11 men additionally drank water "Khrystyna", and the other 11 men - water "Myroslava". The subject of the study were the parameters of the neuroendocrine-immune complex and metabolism. Results. The complex balneotherapy by interval use of sulfate-chloride sodium-magnesium mineral waters with Naftusya water causes significant changes in the constellation of neuroendocrine, metabolic and immune parameters, which are different from the effects of Naftusya water monotherapy. Own effects of mineral waters are estimated by modeling. In general, the effects are physiologically favorable and have a normalizing nature. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets resort have favorable neuroendocrine, metabolic and immune effects on patients with chronic cholecystitis and pyelonephritis.
Gender, Race, and Network Advantage in Organizations
Authors: Castilla Emilio J. 
Published: February 2022

Universities and colleges often engage in initiatives aimed at enrolling students from diverse demographic groups. Although substantial research has explored the impact of such diversity initiatives, less understood is the extent to which certain application strategies may continue to favor historically privileged groups, especially white men, as they seek admission to selective programs. With this study, I begin to address this gap by investigating the gender and racial implications of application endorsements—a common, often informal, network practice of signaling support for certain applicants that is shown to significantly boost an applicant’s chances of admission. Using unique data on the applicants and matriculants to a full-time MBA program at one elite U.S. business school, I first assess whether the endorsement advantage differs across demographic groups. Building on the social networks, selection, and inequality literatures, I then identify and test three key theoretical mechanisms by which the endorsement process may potentially benefit white men more than women and racial minorities. Although I do not find evidence in the studied program that the application endorsement is valued differently by key admissions officers or that it provides a different quality signal depending on the applicant’s gender or race, I do find that white men are significantly more likely than women and minorities to receive application endorsements. I conclude by discussing the implications of this study for understanding how gender and racial differences in accessing advantageous (often informal) network processes may undermine organizational efforts to achieve demographic equality and diversity. Funding: Financial support from the James S. Hardigg (1945) Work and Employment Fund and the MIT Sloan School of Management is gratefully acknowledged.
Systematic error analysis and parameter design of a vision-based phase estimation method for ultra-precision positioning
Authors: Cheng Qinrui , Xu Ting , Huang Peisen 
Published: February 2022

Ultra-precision position measurement is increasingly important in advanced manufacturing such as the semiconductor industry and fiber optics or photonics. A vision-based phase estimation method we proposed previously performs position measurement by imaging a 2D periodic pattern. In this paper, systematic errors of this method are analyzed and derived mathematically, which are classified into two types: spectrum leakage error caused by image truncation and window function modulation, and sub-pixel error resulting from discrete Fourier transform (DFT) intensity interpolation. Key design parameters are concluded including pattern period T, camera pixel size t and resolution N, as well as the type of window function used. Numerical simulations are conducted to investigate the relationship between the phase errors and design parameters. Then an error reduction method is proposed. Finally, the improved performance of parameter optimization is validated by a comparative experiment. Experimental results show the measurement errors of the prototype are within ∼2 nm in X or Y axis, and ∼1 µrad in axis, which reaches the sub-pixel accuracy better than 10−3pixel.
Factors affecting intention to take COVID-19 vaccine among Pakistani University Students
Authors: Hossian Mosharop , Khan Md Abdullah Saeed , Nazir Anum , Nabi Mohammad Hayatun , Hasan Mehedi , Maliha Ramisha , Hossain Mohammad Ali , Rashid Md Utba , Itrat Nizwa , Hawlader Mohammad Delwer Hossain 
Published: February 2022

Background
Widespread vaccination coverage is essential for reducing the COVID-19 havoc and regarded as a crucial tool in restoring normal life on university campuses. Therefore, our research aimed to understand the intention to be vaccinated for COVID-19 among Pakistani university students.

Methods
This cross-sectional study was conducted in five administrative units of Pakistan, i.e., Punjab, Sindh, Balochistan, Azad Jammu and Kashmir, and Khyber Pakhtunkhwa. We obtained data from 2,865 university students between 17th January and 2nd February, 2021, using a semi-structured and self-administered questionnaire. We used Stata (version 16.1, StataCorp LLC) for data management and analysis.

Results
The majority (72.5%) of our respondents were willing to take COVID-19 vaccine. The current level of education had a statistically significant relationship with the intention to be vaccinated (p < 0.05). Respondents answered 11 questions encompassing five different domains of the Health Belief Model (HBM). All the items of HBM were significantly associated with the positive intention towards receiving the vaccine (p < 0.05). We conducted a multivariable logistic regression analysis to assess the relative contribution of different factors towards the intention to receive COVID-19 vaccine. Multiple factors such as belief that vaccination should be mandatory for everyone (AOR: 3.99, 95% CI: 3.20–4.98) and willingness to take vaccine even if it is not free (AOR: 3.91, 95% CI: 3.18–4.81) were observed to be associated with high odds of showing willingness to be vaccinated against COVID-19.

Conclusion
Most of our study participants intended to take vaccines based on their belief regarding the high effectiveness of COVID-19 vaccine. But as rumor-mongers are generating and spreading conspiracy theories daily, the health department and policymakers need to undertake evidence-based campaigns through electronic and social media to ensure expected countrywide vaccination coverage. In this case, our study findings can serve as a foundation for them to ensure mass vaccination coverage among university students, which is crucial now to reopen the dormitories and restore everyday life on campuses.
Restenosis rates in patients with ipsilateral carotid endarterectomy and contralateral carotid artery stenting
Authors: Nguyen Dat Tin , Vokó Boldizsár , Nyárádi Balázs Bence , Munkácsi Tamás , Bérczi Ákos , Vokó Zoltán , Dósa Edit 
Published: February 2022

Purpose
We aimed to evaluate the long-term outcome of carotid endarterectomy (CEA) and carotid artery stenting (CAS) in patients who underwent both procedures on different sides.

Methods
In this single-center retrospective study (2001–2019), 117 patients (men, N = 78; median age at CEA, 64.4 [interquartile range {IQR}, 57.8–72.2] years; median age at CAS, 68.8 [IQR, 61.0–76.0] years) with ≥50% internal carotid artery stenosis who had CEA on one side and CAS on the other side were included. The risk of restenosis was estimated by treatment adjusted for patient and lesion characteristics.

Results
Neurological symptoms were significantly more common (41.9% vs 16.2%, P<0.001) and patients had a significantly shorter mean duration of smoking (30.2 [standard deviation {SD}, 22.2] years vs 31.8 [SD, 23.4] years, P<0.001), hypertension (10.1 [SD, 9.8] years vs 13.4 [SD, 9.1] years, P<0.001), hyperlipidemia (3.6 [SD, 6.6] years vs 5.0 [SD, 7.3] years, P = 0.001), and diabetes mellitus (3.9 [SD, 6.9] years vs 5.7 [SD, 8.9] years, P<0.001) before CEA compared to those before CAS. While the prevalence of heavily calcified stenoses on the operated side (25.6% vs 6.8%, P<0.001), the incidence of predominantly echogenic/echogenic plaques (53.0% vs 70.1%, P = 0.011) and suprabulbar lesions (1.7% vs 22.2%, P<0.001) on the stented side was significantly higher. Restenosis rates were 10.4% at 1 year, 22.3% at 5 years, and 33.7% at the end of the follow-up (at 11 years) for CEA, while these were 11.4%, 14.7%, and 17.2%, respectively, for CAS. Cox regression analysis revealed a significantly higher risk of restenosis (hazard ratio [HR], 1.80; 95% confidence interval [CI], 1.05–3.10; P = 0.030) for CEA compared to that for CAS. After adjusting for relevant confounding factors (smoking, hypertension, diabetes mellitus, calcification severity, plaque echogenicity, and lesion location), the estimate effect size materially did not change, although it did not remain statistically significant (HR, 1.85; 95% CI, 0.95–3.60; P = 0.070).

Conclusion
Intra-patient comparison of CEA and CAS in terms of restenosis tilts the balance toward CAS.
Effect of empagliflozin on coronary microvascular function in patients with type 2 diabetes mellitus–A randomized, placebo-controlled cross-over study
Authors: Suhrs Hannah Elena , Nilsson Malin , Bové Kira Bang , Zander Mette , Prescott Eva 
Published: February 2022

Purpose
Results from large scale cardiovascular outcome trials in patients with type 2 diabetes mellitus (DM2) have found that sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce cardiovascular death and hospitalization for heart failure, but the mechanisms behind the beneficial cardiovascular effects are not fully understood. We tested the hypothesis that the SGLT2i, empagliflozin, improves non-endothelial dependent coronary microvascular function, thereby leading to better cardiac function.

Methods
Patients with DM2 followed at the endocrinology outpatient clinic at Bispebjerg University Hospital were included in a double blinded, placebo-controlled cross-over study. Participants were allocated equally to each treatment sequence using simple randomization and treated with empagliflozin 25 mg and placebo for 12 weeks, interrupted by 2 weeks wash-out period. The primary outcome was coronary microvascular function, assessed as coronary flow velocity reserve (CFVR) and measured with transthoracic doppler echocardiography. Echocardiographic parameters of cardiac function were measured, and blood samples were analyzed for a broad panel of cardiovascular biomarkers.

Results
Thirteen patients were randomized to each sequence and 10 and 9 completed the study according to protocol, respectively, and were included in the analysis of outcome parameters. We found no improvement in CFVR (change in the empagliflozin period was -0.16 (SD 0.58)). There were no effects on cardiac systolic function or indicators of cardiac filling pressure. Well-known effects of empagliflozin were obtained, such as weight loss and reduction in Hba1c level. Creatinine level increased but remained within normal range. We observed a clear trend of reduction in cardiovascular biomarkers after empagliflozin treatment and increased levels after the placebo period. No serious adverse reactions were reported.

Conclusions
Despite effect on weight-loss, Hba1c and biomarkers, treatment with empagliflozin for 12 weeks did not improve CFVR in patients with DM2.
Low birth weight and associated factors among HIV positive and negative mothers delivered in northwest Amhara region referral hospitals, Ethiopia,2020 a comparative crossectional study
Authors: Fentie Elsa Awoke , Yeshita Hedija Yenus , Bokie Moges Muluneh 
Published: February 2022

Background
Even though pregnancy does not affect HIV infection progression, HIV affects the pregnancy outcome. Maternal HIV infection has many untoward effects which include low birth weight which is the major cause of neonatal, infant, and under-five mortality. However, there is controversy and limited information about the effect of HIV status on birth weight around the world including Ethiopia. Therefore, this study aimed to compare the prevalence of LBW and their associated factors among HIV+ and HIV- mothers delivered in Northwest Amhara region referral hospitals.

Method
A comparative crossectional study was conducted from September 2016 to September 2019. A simple random sampling technique was used to select 474 participants. Data were collected from the mothers’ chart by using a data extraction sheet and then entered into Epi-data and exported into SPSS for analysis. Independent variables with p-values < 0.2 in the bivariable analysis were entered into multivariable logistic regression models with backward logistic regressions method to control confounders and identify the factor.

Result
The overall prevalence of LBW was 13.9% (95% CI:10.8%-17.1%). The prevalence was higher among HIV+ 17.7% (95% CI:14.1%-22.8%) than HIV- mothers 10.1% (95% CI:6.3%—13.8%). CD4 count < 200 cells/mm3 [AOR 3.2, 95%CI (1.05, 9.84)] and between 200–350 cells/mm3 [2.81, 95% CI (1,08, 7.28)], Mothers with MUAC <23 cm [AOR 3.39, 95% CI (1.41, 8.18)] and gestational age <37 weeks [AOR 7.34, 95% CI (3.02,17.80)] were significantly associated with LBW in HIV+ mothers. While, rural residence [AOR 3.93,95% CI (1.356,11.40)], PROM during current pregnancy [AOR 4.96, 95% CI (2.55, 15.83)] and gestational age <37 week [AOR 8.21, 95% CI (2.60, 25.89)] were significantly associated with LBW in HIV negative mothers.

Conclusion
The prevalence of LBW was significantly higher among HIV+ mothers as compared to HIV—mothers and this study suggests to emphasize nutritional supplementation of HIV positive mothers, needs to focus on nutritional counseling during ANC/PMTCT follow up and encourage HIV positive mothers to delay their pregnancy until their immune status improve.
A detailed investigation on highly dense CuZr bulk metallic glasses for shielding purposes
Authors: Tekin Huseyin Ozan , ALMisned Ghada , Susoy Gulfem , Zakaly Hesham M. H. , Issa Shams A. M. , Kilic Gokhan , Rammah Yasser Saad , Lakshminarayana Gandham , Ene Antoaneta 
Published: February 2022

Abstract
Gamma-ray shielding properties of eight different metallic glasses based on CuxZr100-x: x = 35 (Cu35Zr65) − 70 (Cu70Zr30) were determined using Monte Carlo simulations and Phy-X/PSD software. A typical gamma-ray transmission setup has been modeled in MCNPX Monte Carlo code. The general trend of the linear attenuation coefficients (μ) was reported as (μ)Cu35Zr65 < (μ)Cu40Zr60 < (μ)Cu45Zr55 < (μ)Cu50Zr50 < (μ)Cu55Zr45 < (μ)Cu60Zr40 < (μ)Cu65Zr35 < (μ)Cu70Zr30. In terms of half value layer (HVL) values, the Cu35Zr65 sample has the highest value (2.984 cm) and the Cu70Zr30 sample has the lowest value (2.769 cm) at 8 MeV photon energy. The mean free path (MFP) values were 4.305 and 3.995 cm for Cu35Zr65 and Cu70Zr30 samples, respectively. Generally, MFP and HVL values of the studied glasses were reported as (MFP,HVL)Cu35Zr65 > (MFP,HVL)Cu40Zr60 > (MFP,HVL)Cu45Zr55 > (MFP,HVL)Cu50Zr50 > (MFP,HVL)Cu55Zr45 > (MFP,HVL)Cu60Zr40 > (MFP,HVL)Cu65Zr35 > (MFP,HVL)Cu70Zr30 for all photon energy range. The Cu70Zr30 sample showed maximum values of both the effective conductivity (C
eff) and effective electron density (N
eff). In addition, the Cu70Zr30 sample has minimum exposure and energy absorption buildup factor (EBF and EABF) values at all studied gamma-ray energies. The results revealed that the Cu70Zr30 sample has superior attenuation properties among all studied samples.
Some physicochemical and technological properties of cooking water of pulses as a canned industry waste: effect of ultrasound treatment during soaking
Authors: Kilicli Mahmut , Toker Omer Said 
Published: February 2022

Abstract
Canned products are important part of human diet and therefore, many types of canned products with high amounts are produced worldwide. During canned production, cooking water of pulses (aquafaba) is an important waste. Therefore, recycling of it is important for sustainability and economic value. In the present study, it was aimed to determine technological properties of aquafabas obtained from canned production. For this aim, chickpea, bean, kidney bean, broad bean, green pea and lentil were used in this study, and conventional soaking and ultrasound soaking was both performed. Aquafaba is a cooking water of pulses not only chickpea and also lentil, pea and bean species. Aquafaba is used for foaming, emulsifying and gelling agent as a plant based food additive. Soaking with ultrasound has shortened the soaking time of all pules as well as increased the D
eff (effective diffusion constant) values. Diffusion is a basic physical mechanism for remove moisture or absorb and also give important information about physical and thermal properties of sample. “Remove moisture” term is using for drying and the other is using for hydration. The relationship between the physical properties of pulses and D
eff values was observed. The protein content of aquafaba on a dry basis changed between 20 and 35% and it has been observed that there are also positive correlation with their foaming properties. Foaming capacities of aquafabas varied between 167 and 567% in conventional soaking, and between 133 and 533% in ultrasonic soaking. In both methods, chickpea aquafaba showed the lowest foaming capacity and stability, while pea had the highest foaming capacity and stability. US process generally decreased the protein content and foaming capacity (FC) of aquafabas. The foam of pea and lentil aquafabas showed higher resistant against to gravity. In contrary to the foaming properties, an increase in emulsifying properties was observed as a result of US. It has been observed that the obtained aquafabas can be used in various products in the food industry thanks to their technological features instead of animal-based ingredients.
On the influence of heavy warm reduction on the microstructure and mechanical properties of a medium-carbon ferritic –pearlitic steel
Authors: Storojeva L. , Ponge D. , Raabe D. , Kaspar R. 
Published: February 2022

Abstract
The current study on a medium-carbon steel (0.36% C) with deformation-induced spheroidized cementite produced by heavy warm deformation (HWD) was carried out in order to investigate an alternative microstructural route when compared to conventional quenching and tempering (QT) or soft annealing (SA) processes. After austenite deformation, the HWD samples were cooled and heavily deformed at temperatures below the γ–α transformation followed by a simulated coiling treatment. In particular, the study addresses the influence of adiabatic heating due to the heavy deformation on the microstructure and properties. The mechanical properties after the various treatments show that the strength – ductility relation after HWD and QT are superior to those after continuous cooling (CC) or soft annealing (SA). In the microstructures obtained from the CC and SA treatments we observed lamellar pearlite which deteriorated the mechanical properties. A similar effect was observed after the adiabatic HWD treatment, which also entails some lamellar pearlite. HWD at 670 °C with subsequent coiling produced a microstructure with dispersed spheroidized cementite distributed homogeneously in the fine-grained ferrite matrix. The mechanical properties of the HWD samples are well comparable to those observed after the QT process owing to the resemblance in microstructure.