bluuebunny/crossref_metadata_2025_split huggingface dataset:
The "Narkomfin" and "La Nao" apartments. Contributions to section 3-2
Authors: Peris Blat Ignacio , Sanchis Gisbert Salvador José , Ponce Gregorio Pedro 
Published: December 2022

ResumenEntre los frutos de las investigaciones llevadas a cabo por el Departamento de Estandarización del Stroikom en la antigua URSS, encontramos el llamado tipo F que se convertirá en un referente para la arquitectura residencial de la modernidad. Su característica sección 3-2, materializada en el edificio "Narkomfin" (Moscú, 1928-1930), supone una importante aportación a las posibilidades espaciales de la vivienda colectiva y ha sido un modelo para un gran número de realizaciones posteriores. Entre todas ellas, nos resulta especialmente interesante, para su confrontación con la obra de Moscú, el caso de los apartamentos "La Nao" (Jávea, 1962-1966) de Santiago Artal, por tratarse de una obra muy poco conocida y estudiada. Este edificio es la continuación de la labor iniciada por el arquitecto valenciano en su primer trabajo de "Santa María Micaela". A partir del análisis y del redibujado de las viviendas, y pese a tratarse de dos actuaciones de escalas y contextos urbanos muy diferentes, trataremos de hacer un estudio comparado que nos permita poner en valor esta obra de Artal dentro del contexto arquitectónico de los primeros años 60. Abstract Among the results of the research carried out by the Standardization Department at Stroikom in the former USSR, we find the so-called F-type, which became a reference for modern residential architecture. Its distinctive 3-2 section, materialized in the "Narkomfin" building (Moscow, 1928-1930), represents an important contribution to the spatial possibilities of collective housing and has been a model for a large number of subsequent projects. Among all of them, the case of the "La Nao" apartments (Jávea, 1962-1966) by Santiago Artal is particularly interesting for its comparison with the Moscow building, as it is a little-known and little-studied work. This building is the continuation of the endeavor the Valencian architect began with his first work on "Santa María Micaela". Based on the analysis and the redrawing of the dwellings, and despite being two works with very different scales and urban contexts, we will try to carry out a comparative study that will allow us to highlight Artal's work within the architectural context of the early 1960s.
Development of legislative bases regulating the legal status of foreign citizens in pre-revolutionary Russia of the 18<sup>th</sup>–20<sup>th</sup> centuries
Authors: Kobets P. N. 
Published: December 2022

Objective: the research was conducted in order to analyze historical and legal events related to the genesis of the legislative framework for regulating the legal status of foreign citizens in the pre-revolutionary period in the Russian Empire of the 18th – 20th centuries.Methods: the methodological basis of the work includes the following methods: comparative legal, historical and legal analysis, comparison, synthesis. The author also used specific scientific methods; while solving research tasks, the main processes and events of pre-revolutionary Russian history and rulemaking in the field of migration were studied and analyzed. This approach allowed considering and analyzing the main body of legislative acts of the Russian Empire of the 18th – 20th centuries which regulated the legal status of foreigners to varying degrees.Results: during the analysis of the genesis of the pre-revolutionary period of the legislative framework for regulating the legal status of foreign nationals, it becomes obvious that our country has a good historical experience in this sphere, which could be fully used today. In the course of the research, the author convincingly proved that with the development of the Russian state, the rights of foreign citizens changed. In particular, by activating international relations at the beginning of the 18th century, the Russian authorities did not hinder the processes as a result of which foreign citizens occupied a privileged position in Russia, which necessitated the legal regulation of their status. Characterizing the peculiarities of the legal status of the persons in question, the author focuses on the absence of a single legislative act defining the rights and obligations of foreigners. The author also concludes that in the Russian Empire, the implementation of only Russian legislative norms in relation to foreign subjects was recognized, which served as a basis for foreigners in the country to obey exclusively Russian legislation and be protected by it.Scientific novelty: the work for the first time reveals the essence and patterns of social relations associated with the development of legislative frameworks for regulating the legal status of foreign citizens in pre-revolutionary Russia, compares crisis migration situations of today and other historical epochs, and identifies a strategy and tactics for the legal regulation of problematic migration processes.Practical significance: the main provisions and conclusions of the article can be used in scientific and pedagogical activities when considering the issues related to the study of the legal status of foreign citizens in pre-revolutionary Russia.
Guns for hire: North America’s intra-continental gun trafficking networks
Authors: Leuprecht Ch. , Aulthouse A. 
Published: December 2022

Objective:to summarize and study the North America’s intra-continental gun trafficking networks.Methods:the work applies social network analysis (SNA) to understand structures, identify brokers and discover patterns in the way guns are being procured, transported across the border, and further distributed.Results:Since Canada adjoins the largest weapons market in the world, it is unsurprising that guns used to commit criminal acts in Canada largely originate in the United States. But how are such weapons transported across the border: by individual entrepreneurs, by small networks, or by sophisticated cartels? This article analyzes six cases that resulted in prosecutions of 40 Canadian and American citizens implicated in Canada-U.S. gun trafficking networks between 2007 and 2010. This study is a plausibility probe that applies social network analysis—investigating networks that come into existence by the creation of pairwise links among their members—to analyze global structures, identify brokers and their roles, and discover patterns in the way guns are being procured in the United States, transported across the border, and distributed in Canada.Scientific novelty: In the process, this study generates hypotheses about network structure and works towards modeling these networks functionally: Since guns are available legally in the United States, we expect to find a proliferation of relatively simple networks. In contrast, drugs, which are not as readily available, might require more sophisticated networks to be trafficked across the border. Results revealed that the trafficking network structures seem to be driven by function. When the objective of the network is mere rent-seeking, transborder trafficking networks for guns tend to be simple. By contrast, when the objective is to manage violence as a constituent element of a larger criminal organization and its activities, networks tend to be more sophisticated, although the gun trafficking networks remain simpler.Practical significance: the main provisions and conclusions of the article can be used in scientific, pedagogical and law enforcement activities when considering the issues related to the illegal firearms trafficking through the US and Canadian territories.
Identification and validation of hub genes based on machine learning in prostate cancer and AOX1 is an oxidative stress-related biomarker
Authors: Hu Di , Yuan Kaisheng , Mo Xiaocong , Huang Cheng , Luo Juyu , Liu Hang , Li Yin 
Published: December 2022

Abstract
Objectives To explore the potential diagnostic and prognostic biomarkers associated with prostate cancer (PCa).
Methods We downloaded from the Gene Expression Omnibus (GEO) database, six previously published datasets containing gene expression data (GSE8511, GSE14206, GSE46602, GSE55945, GSE69223, and GSE71016). Take GSE8511, GSE14206, GSE46602, and GSE55945 as the training group (127 PCa cases and 52 normal controls) and GSE69223 and GSE71016 as the test group (63 PCa cases and 62 normal controls). Between 127 PCa cases and 52 normal controls, differentially expressed genes (DEGs) were filtered. Following that, candidate PCa biomarkers were discovered using a least absolute shrinkage and selector operation (LASSO) regression model and support vector machine recursive feature elimination (SVM-RFE) analyses. We conducted a difference analysis for these genes in the test group, and a significance level of P< 0.05 was considered statistically significant. To determine the train group’s discriminating ability, the area under the receiver operating characteristic curve (AUC) value was acquired and utilized, with hub genes defined as those having an AUC greater than 85%. The biomarkers’ expression levels and diagnostic utility in PCa were confirmed further in the GSE69223 and GSE71016 datasets. Lastly, to assess the relevant invasion of cells per every sample, the CIBERSORT algorithm and the ESTIMATE technique were utilized.
Results The possible PCa diagnostic biomarkers AOX1, APOC1, ARMCX1, FLRT3, GSTM2, and HPN were found and verified using the GSE69223 and GSE71016 datasets. Immune cell infiltration analysis revealed that AOX1, APOC1, ARMCX1, FLRT3, GSTM2, and HPN were correlated with Mast cells resting, Macrophages M0, Macrophages M2, Neutrophils, NK cells activated, T cells CD4 memory resting, T cells gamma delta, T cells follicular helper, T cells CD4 naive and B cells memory. Meanwhile, AOX1 was identified as an oxidative stress-related biomarker that could use to be a prognostic biomarker. From expreimental validations, we detected that AOX1 was lowly expressed in PCa cell lines. Overexpression of AOX1 clearly reduced the proliferation and migration of the PCa cells, the anti-tumor effect of APX1 may be related to oxidative stress.
Conclusion We used a multi-pronged approach to identify PCa biomarkers and examine the important function of infiltration of cells in PCa. AOX1, APOC1, ARMCX1, FLRT3, GSTM2, and HPN can be used as diagnostic markers of PCa, and AOX1 can be used to predicting the prognosis, which providing new perspectives into the incidence and molecular mechanisms of PCa in the future.
Biological survival optimizer: a new nature-inspired computation technique for engineering optimization
Authors: zhang qingyang , He Xiangyu , Yang Shengxiang , Jiang Shouyong , Dong yongquan , Song Hui 
Published: December 2022

Abstract
This study proposes a novel and lightweight bio-inspired computation technique named biological survival optimizer (BSO), which simulates the escape behavior of prey in the natural environment. This algorithm consists of two important courses, escape phase and adjustment phase. Specifically, in the escape phase, each search agent is required to updates its location using the best, the worst and a neighboring individual of the population. The adjustment phase is implemented using the simplex algorithm for search better location of the worst agent within a small region. The effectiveness of the BSO is validated on the CEC2017 benchmark problems and three classical engineering structural problems. Simulation comparison results considering both convergence and accuracy simultaneously show that BSO can present competitive performance compared with other state-of-art optimization techniques.
Epidemiology and Survival Analysis of Patients with Brainstem Cavernous Hemangioma: A Population-Based Study Using the SEER Database
Authors: Zhan Zhixin , He Ding , Jiang Heng , Yang Zedi , Gao Peigeng , Zhang Sheng , Chen Yong , Huang Haiyan 
Published: December 2022

Abstract
This population-based study determined the epidemiology, incidence, and outcomes of brainstem cavernous hemangioma. Data on patients with brainstem cavernous hemangioma were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Descriptive analysis assessed the distribution and tumor-related characteristics of patients with brainstem cavernous hemangioma. The Kaplan–Meier method and Cox proportional hazard model were used to analyzed the possible prognostic indicators. The age-adjusted incidence rate between 2000 and 2019 was 0.0236 cases per 100,000 person-years. A total of 283 cases of brainstem cavernous hemangioma were identified between 2000 and 2019. The median patient age was 45 years (range, 0–87 years). Most patients were diagnosed between 40–44 and 55–59 years of age. Middle-aged adults (40–59 years old) accounted for 41.34% of all patients. White patients accounted for 82.6% of all patients. All patients diagnosed with brainstem cavernous hemangioma had benign lesions. Surgery was performed in 105 (37.1%) cases, radiation therapy in 5 (1.7%) cases, and chemotherapy in 1(0.4%) case. The median survival time was 71 months (range: 0–189 months). Age at diagnosis and surgery were two strong factors affecting occurrence and prognosis. Incidence did not differ between sexes and was higher in white patients. Tumor size had little impact on early prognosis; however, for late prognosis, smaller tumors (< 3 cm) had a better prognosis. No significant differences were observed in the outcomes between surgery and conservative treatment. We recommend that the treatment of patients with brainstem cavernous hemangioma should be tailored to the patient's situation (e.g., age, tumor size, possible surgical benefit, etc.) and should be individualized after taking into account.
Business sustainability behaviour and alignment with climate targets
Authors: Cenci Simone , Burato Matteo , Rei Marek , Zollo Maurizio 
Published: December 2022

Abstract
Climate actions by the private sector are crucial to cutting global emissions and meeting the climate targets set by the Paris Agreement. In recent years, an increasing number of companies have pledged to help achieve those targets. However, the emissions pathways of most firms are still not aligned with these goals. To explain the root causes of this discrepancy between effort and outcome, we developed a new methodology to track the actions implemented by major public corporations to reduce their emissions. Our analysis shows that firms with emissions pathways aligned with climate targets prioritise actions focused on creating growth opportunities, such as investing in research and development and new products as well as fostering cooperation with other ecosystem players. Overall, we provide a new systematic framework to track the effort of major corporations to align their emissions with climate targets. Our approach can be used by investors and policymakers to redirect capital towards its most sustainable use and to design behaviourally founded policy interventions to align business emissions with climate targets.
Association between Vitamin D and pregnancy in women with polycystic ovary syndrome: a case-control study from Beijing, China
Authors: Piao Chunmei , Li Jia , Zhao Zhihong , Wang Kefang 
Published: December 2022

Abstract
Background
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. Several evidence show that vitamin D may be beneficial to female reproduction in PCOS. However, few studies have been done to the correlation between vitamin D levels and pregnancy in PCOS patients after ovulation induction therapy.
Methods
We enrolled a total of 200 newly diagnosed anovulatory infertile patients with PCOS (experimental group) and 200 healthy women of childbearing age (control group) between June 2016 and September 2018. The experiment group treated with Letrozole for inducing ovulation. We investigated the pregnancy rate for patients with PCOS and studied correlation of pregnancy rate and levels of 25-(OH) D3 in patients with PCOS. Then we evaluated serum 25-(OH) D3 levels between the two subgroups, with the experimental group divided into vitamin D-deficient and vitamin D non-deficient subgroups and analyzed their respective pregnancy rates.
Results
The mean serum 25-(OH) D3 level in the experimental group was significantly lower than that in the control group (14.57 ± 5.86 ng/mL vs. 22.24 ± 6.73 ng/mL, respectively; t = 12.190, P < 0.05). Of the 200 patients in the experimental group, 149 patients completed the ovulation-induction regimen, comprising 72 patients who became pregnant and 77 patients who failed to become pregnant—generating a pregnancy rate of 48.32%. We noted that the serum 25-(OH) D3 level in the pregnant patients was significantly higher than that in the non-pregnant patients (16.06 ± 5.80 ng/mL vs. 13.54 ± 5.88 ng/mL, respectively; t = 2.635, P < 0.05). Additionally, the pregnancy rate was 43.89% in the vitamin D-deficient group compared to 67.86% in the vitamin D non-deficient group, with the latter significantly higher compared to the former group (χ2 = 5.269, P < 0.05).
Conclusions
Our results demonstrate that vitamin D deficiency is common in women with PCOS and vitamin D appears to play a beneficial role in PCOS patients undergoing an ovulation-induction regimen. Therefore, monitoring the serum vitamin D level in PCOS patients and timely and appropriate vitamin D supplementation are essential to improve the pregnancy success rate of infertile women with PCOS.
Impact of the COVID-19 Pandemic on HIV Clinic Site Services and Strategies for Mitigation in Washington, DC
Authors: Barish Nicole , Barth Shannon , Castel Amanda D. , Monroe Anne K. , Greenberg Alan E. 
Published: December 2022

Abstract
Introduction

The COVID-19 pandemic has created substantial interruptions in healthcare presenting challenges for people with chronic illnesses to access care and treatment services. We assessed the impact that the pandemic has had on the care of people with HIV (PWH) by characterizing the pandemic-related impact on HIV clinic-level services and the mitigation strategies that were developed to address them.

Methods

The data comes from a site assessment conducted in the DC Cohort, an observational clinical cohort of PWH receiving care at 14 HIV outpatient clinics in Washington, D.C. Frequency counts and prevalence estimates of clinic-level survey responses about the impact of care delivery, COVID-19 testing, and vaccinations and mitigation strategies are presented.

Results

Clinics reported an increase in temporary clinic closures (n = 2), reduction in clinic hours (n = 5), telehealth utilization (n = 10), adoption of multi-month dispensation of antiretroviral medication (n = 11) and alternative drug delivery via postal/courier service, home/community delivery or pick-up (n = 11). Clinics utilized support strategies for PWH who were lost to follow-up during the pandemic including offering care to persons with any income level and insurance status (n = 9), utilizing e-prescribing for auto refills even if the patient missed visits (n = 8), and utilization of the regional health information exchange to check for hospitalizations of PWH lost to follow-up (n = 8). Most social services offered before the pandemic remained available during the pandemic; however, some support services were modified.

Conclusions

Our findings demonstrate the extent of pandemic-era disruptions and the use of clinic-level mitigation strategies among urban HIV clinics. These results may help prepare for future pandemic or public health emergencies that disrupt healthcare delivery and access.
The Effect of Anti-coagulation Dosage on the Outcome of Hospitalized COVID-19 Patients in Ethiopia: A multi-center retrospective cohort study
Authors: Tessema Abel Girma , Mengiste Zekarias Masresha , Hundie Tsegaye Gebreyes , Yosef Hailemichael Getachew , Huluka Dawit Kebede , Seyoum Abebaw Bekele , Abate Hannibal Kassahun , Howe Rawleigh Craig 
Published: December 2022

Abstract
Background:
Studies have indicated that hospitalized COVID-19 patients benefit from anticoagulation therapy in terms of survival; however, there is an ongoing controversy over the optimum anticoagulant dosage. This study aimed to compare clinical outcomes between patients who received prophylactic anticoagulation and those who received therapeutic anticoagulation.
Methods:
A multi-center retrospective cohort study was conducted to determine the impact of anticoagulation dosage in hospitalized COVID-19 patients in Ethiopia. The primary outcome measure was in-hospital mortality, and it was assessed using multivariable binary logistic regression and covariate-adjusted Cox Proportional Hazard model. For critical and severe COVID-19 patients, subgroup analyses were performed using multivariable binary logistic regression model and multivariable Cox regression models.
Result:
A total of 472 hospitalized COVID-19 patients were included in this study, of whom 235 (49.8%) received therapeutic anticoagulation and 237 (50.2%) received prophylactic dose. The demographic and baseline clinical characteristics were roughly similar between the groups. After adjustment for several confounders, in critical COVID-19 subgroup, therapeutic dose of anticoagulation was significantly associated with a higher inpatient mortality (AOR 2.27, 95% CI, 1.18 - 4.35, p = 0.013), whereas in severe COVID-19 subgroup, anticoagulation dosage was not associated with inpatient mortality (OR, 1.02, 95% CI, 0.45 – 2.33, p = 0.958). In severe COVID-19 patient group however, the incidence of thrombosis was slightly lower in the therapeutic group as compared with prophylactic group although the difference was not statistically significant (AOR 0.15, 95% CI, 0.02 – 1.20, p =0.073). Although there were only six major bleeding events in this study, all these were recorded from patients in the therapeutic subgroup, making the difference statistically significant (p = 0.013).
Conclusion:
Our findings suggest that, in critical COVID-19 patients, when compared to prophylactic anticoagulation, therapeutic anticoagulation may offer no survival advantage, no improved protection against thrombosis and pose a higher risk of bleeding. In severe COVID-19 subgroup, therapeutic anticoagulation may prolong hospital stay and not improve survival, although it may offer a slight protection against thrombosis. These findings suggest that the benefit of therapeutic anticoagulation for hospitalized COVID-19 patients should be further studied, if possible, with a randomized control trial in this setting.
Association between handgrip strength and depression among Chinese older adults: a cross-sectional study from the China Health and Retirement Longitudinal Study
Authors: Zhang Fan , Yu Yaqi , Wang Hui , Zhang Ying , Bai Yan , Huang Liuyan , Zhang Huachun 
Published: December 2022

Abstract
Purpose: This study aimed to quantify the bidirectional association between handgrip strength (HGS) and depression in community-dwelling older adults.
Methods: Research data were obtained from the China Health and Retirement Longitudinal Study (CHARLS). Depression was assessed using the Center for Epidemiologic Studies Depression Scale (CESD) with a cut-off score of 20 or more. HGS was assessed with a dynamometer. Binary logistic regression and multiple linear regression models were used to test the bivariate association between HGS and depression.
Results: The sample consisted of 7,036 CHARLS participants, with an average age of 68.9±7.2. After adjusting for potential confounders, compared with participants in the lowest quartile of HGS, those in the second to the fourth quartile group had a 0.84-, 0.70- and 0.46-fold risk of depression, respectively. Conversely, HGS decreased by approximately 1.54 kg in the presence of depression compared to participants without depression.
Conclusions: There were a negative bidirectional association between HGS and depression in community-dwelling older adults. It is critical to assess muscle strength in community older adults through accessible and valid objective measures to enhance depression screening.