bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between 25 hydroxyvitamin D concentration and abortion: a retrospective study and a Mendelian randomization study
Authors: Zhang Hongping , Ding Xingru , Hu Xianqing , Sun Congcong , cheng Jingjing , Li Xiaoqing , Zheng Zhengzheng , Cheng Haiying , Liao Tingting , Zhao Na , Zhong Mingchen , Fang Rujing , Huang Xiu-Feng , Zheng Jianqiong 
Published: September 2022

Abstract
Background: Abortion was defined as loss at a gestational age less than 28 weeks. Vitamin D is reported to be associated with reproductive functions, whereas its casual effects on abortion remains unclear. In this study, a two-sample Mendelian randomization (MR) analysis was performed to systematically assess the causal relationships between serum 25 hydroxyvitamin D concentration and the risk of abortion.
Results: GWAS summary data of vitamin D was used as exposure, and data of missed abortion and spontaneous abortion was considered as outcome. A retrospective study was also conducted to verify the associations identified from MR study. MR estimates showed that a higher Vitamin D level was associated with decreased risk of both missed abortion and spontaneous abortion. However, the P value was not significant. We then conducted a retrospective study, and observed the consistent result of Vitamin D’s protective role to abortion. The value was very close to statistical significance (P=0.0527).
Conclusions: This study reports the potential protective role of serum 25 hydroxyvitamin D concentration to abortion, that is, higher Vitamin D levels can decrease risk of abortion. Further larger retrospective study is needed to confirm this association.
Mapping of groundwater vulnerability using optimized AHP-GOD Models and geospatial factors (Case study: littoral sedimentary aquifer of Ain Temouchent – NW Algeria
Authors: Abdellatif DEHNI 
Published: September 2022

Abstract
The monitoring and protection of coastal aquifers has become a primary priority and a subject of research with the integration of Vertical Electrical Sounding (VES) in order to map groundwater vulnerability to contamination, and to evaluate their aquifer protective capacity. A study aimed to to identify an exposure level of contamination for a sustainable use of the water resources in the aquifer of Ouled Taoui - Boujema aquifer situated in Ain Temouchent – Algeria. For this purpose, a dataset was established including 170 VES soundings, topography ASTER GDEM, geological maps and finally boreholes were acquired to develop the AHP (Analytical Hierarchy Process) by ordering the weightage of geospatial factors in vulnerability mapping. However, a GOD-LT model (G: groundwater type; O: aquifer overlying strata; D: aquifer depth and L: Longitudinal conductance; T: Topography slope and Th: Thickness) has been evaluated using optimized AHP as predictive model abbreviated GOD-L, GOD-LT and GOD-LTh. Furthermore, these factors are considered as the causal factors of aquifer vulnerability (AVCF’s). The geospatial factors were derived on AHP-WLA (Weight Linear Average) for rating optimization. The pairwise comparison matrix was developed on the AVCF’s factors for AHP-GOD. The validation result showcases that 72% of prediction consistency is optimized for GOD-L model compared to 64% for the standard GOD. The GOD-LT and GOD-Th demonstrated the best reliability under consistency index. However, the vulnerability to pollution is validated by using nitrate concentration, water corrosivity and the degree of aquifer capacity protection and can be efficient mapping for water supply and environmental assessment.
Valorization of Solid Food Waste as a Source of Polyunsaturated Fatty Acids using Aurantiochytrium sp. L3W
Authors: Suenaga Toshikazu , Nakai Satoshi , Umehara Akira , Nishijima Wataru , Gotoh Takehiko , Humaidah Nurlaili 
Published: September 2022

Abstract
Purpose: This study aimed at valorizing solid food waste containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).
Methods: Aurantiochytrium sp. L3W that produces DHA and EPA was cultivated on eight types of solid food waste: sake lees (SL), crown daisy, Japanese mustard spinach (JMS), soy sauce residue, lemon peel (LP), orange peel, grape skin, and Hiroshimana old pickle (HOP). The biomass mixture of the remaining food waste and strain L3W was analyzed for DHA and EPA. To characterize the types of food waste, the leachability of dissolved organic carbon (DOC) and dissolved nitrogen (DN) were compared.
Results: The strain L3W grew on both pasteurized and unsterilized food waste such as SL and JMS. Elution of DOC and DN from the food waste might be a factor affecting the growth of strain L3W. However, the strain L3W might utilize solid-state organic compounds in JMS. Despite the unsterile conditions, the biomass mixture of SL contained both DHA and EPA, whereas DHA was found in the biomass mixtures of JMS, LP and HOP, thereby confirming the valorization of these types of solid food waste. Unsterile mass cultivation of the strain L3W using SL and HOP in a 200 L tank also produced a biomass mixture containing 12.6 mg-DHA/g and 0.217 mg-EPA/g. These DHA and EPA contents were 1500-times and 37-times higher, respectively, than that in commercial poultry feed, indicating that these mixtures could be used as an additive in poultry feed.
Optimal insertion depth of central venous catheter through the right internal jugular vein, verified by transesophageal echocardiography
Authors: Lee Jung-Man , Park Ji-Hoon , Oh Sohee , Kang Yeonsoo , Lee Jiwon 
Published: September 2022

Abstract
This prospective observational study investigated the optimal insertion depth of the central venous catheter through the right internal jugular vein using transesophageal echocardiography. After tracheal intubation, the anesthesiologist inserted a probe for esophageal echocardiography into the patient’s esophagus. The investigators placed the catheter tip 2 cm above the crista terminalis with echocardiography, which was defined as the optimal point. We measured the inserted length of the catheter. Pearson correlation tests were performed with the measured optimal depth and some patient parameters. We made a new formula for placing the catheter at the optimal position. A total of 89 subjects were enrolled in this trial. The correlation coefficient between the measured optimal depth and the patient’s parameters was highest for patient height (0.703, p < 0.001). We made a new formula of ‘height (cm)/10–1.5 cm’. The accuracy rate of this formula for the optimal zone was 71.9% (95% confidence interval; 62.4–81.4%), which was highest among the previous formulas or guidelines, when we compared. In conclusion, the central venous catheter tip was evaluated with transesophageal echocardiography, and we could make a new formula of ‘height (cm)/10–1.5’, which seemed to be better than other previous guidelines.
Synthesis of gold nanoparticles from Metarhizium anisopliae for management of blast disease of rice and its effect on soil biological index and physicochemical properties
Authors: Kaman Pranjal , Dutta Pranab , Bhattacharyya Ashok 
Published: September 2022

Abstract

Aims: The aim of this experiment was to synthesized gold nanoparticles from entomopathogen fungi Metarhizium anisopliae, an indigenous biocntrol agent and its antifungal activity against Magnaporthe grisea and its effect on soil biological index and physicochemical properties.
Methods:Biosynthesis of gold nanoparticles was done by following standard protocol and characterized by different equipments. soil biological and ph
ysicochemical properties was carried out by following standard protocol.
Results:Formation of gold nanoparticles were confirmed by UV-VIS spectroscopy study with absorption peaks at 550 nm. FTIR study showed that synthesized gold nanoparticle has all the required functional groups like OH, N-H, C-H and COO-. Study on surface properties of nanoparticles by using zetasizer resulted that gold nanoparticle from Metarhizium anisopliae was found to be negative and were stable in nature with zeta potential value of -20.7 mV. DLS analysis showed that the average size of the biosynthesized gold nanoparticles is 32.54 nm with polydispersity index of 0.560. TEM study showed that shape of the biosynthesized nanoparticle is from triangular to quasihedral and the size range from 9-54nm. Antifungal activity of gold nanoparticles at 150 ppm significantly inhibit the mycelia growth of the pathogens as compared to the Tryclozole @ 600 ppm
Conclusions : A positive effect was found on soil biological index and physicochemical properties of soil along with reduction of disease incidence when rice seedling was treated as seedling dip treatment + foliar spray + Soil application @ 150ppm of biosynthesized gold nanoparticles.
Multi-Characteristic Reinforcement of Horizontally Integrated TENet Based on Wrist Bone Development Criteria for Pediatric Bone Age Assessment
Authors: Jian Kunyuan , Yang Mengning , Wang Simin , Song Cui , Li Shuxiang 
Published: September 2022

Abstract
Pediatric bone age assessment (BAA) is an essential human physiological examination that reflects human growth potential and sexual maturation trends. In clinical practice, the "Methodology for Bone Maturation and Evaluation of the Wrist in Chinese Adolescent Children" (CHN-05) is a widely used method for BAA by Chinese radiologists. CHN-05 adopts the metacarpal length (ML) as well as the metacarpal margin (MM) as reference standards to estimate bone age. Inspired by the semantic description of CHN-05, we propose a new model, called a topology and edge map composed of a network(TENet), for automatic bone age assessment. In TENet, we design a hand topology module to recognize key hand locations and extract structural semantics. In addition, we devise an edge feature enhancement module to supply precise skeletal edge information throughout the training process. Our model can detect the overall message of edges alongside the local message of topology for the purpose of multi-feature horizontally fused assessment of bone age. Experimental results show that our TENet achieves a state-of-the-art model performance of 5.35 mean absolute error (MAE) on the public dataset RSNA. Since our model for designing follows CHN-05 semantic logic, it is reliable and interpretable in terms of clinical use.
A sex-specific thermogenic neurocircuit induced by stressful olfactory inputs.
Authors: Jovanovic Predrag , Morones Nancy , Pool Allan-Hermann , wang Yidan , Novinbakht Edward , Keshishian Nareg , Jang Kaitlyn , Oka Yuki , Riera Celine 
Published: September 2022

Abstract
When detecting danger signals, animals exhibit adaptive changes in physiology and behavior aimed at increasing survival. In small prey animals, such as rodents, olfactory information plays a fundamental role in the perception of their environment and predator avoidance. Exposure to predation has been associated with reduced fatness in male rodents, but whether similar responses exist in both sexes is poorly understood. Exactly how the nervous system regulates weight in the context of danger perception remains unknown. Here we identify a sex-specific response leading to increased energy expenditure and elevated corticosterone in female mice exposed to predator smell or global stimulation of mitral and tufted cells of the olfactory bulb (OB). This response is absent in male mice and is not attenuated by gonadectomy in females. A population of neurons in the dorsomedial hypothalamus (DMH), selectively activated by aversive olfactory signals also receives polysynaptic afferents from mitral and tufted cells of the main OB (MOB). Cell sorting of projection neurons in the DMH receiving olfactory inputs and single-nucleus RNA-sequencing identify cholecystokinin (Cck)-expressing neurons as putative recipients of olfactory inputs. Chemogenetic stimulation of DMHCCK neurons recapitulates the effects of aversive olfactory stimulation on female energy expenditure. Taken together, our results suggest the existence of a female heightened stress reaction recruiting DMHCCK neurons to promote high energy utilization.
Investigating the Relationship between COVID-19 and Mental Health: A Survey of Stress, Loneliness, and Substance Abuse among the US General Population
Authors: Strayhorn Terrell 
Published: September 2022

Abstract

Background
Health officials have called for more information about the mental or psychological consequences of COVID-19 on individuals, especially in the US general population where COVID rates are remarkably high.
Aims
This exploratory study aimed to understand stress, loneliness and substance abuse among the US general population during the COVID-19 pandemic.
Methods
A cross-sectional study comprising 1,203 respondents to a controlled-access, web-based survey was conducted.
Results
Study results reveal statistically significant differences in stress (p<0.001), loneliness (p<0.001), and substance (ab)use (p<0.001), especially illicit (non-prescription) drug use, between those with COVID-19 or related symptoms and those without. Effect size estimates indicate small to moderate effects, ranging from 0.178 to 0.276, consistent with prior studies based on past outbreaks.
Conclusions
Findings have significant implications for mental health practitioners, community organizations, and federal agencies in terms of policy, practice, and future research.
Shape-stable composite phase change materials encapsulated by Lignin-based ordered porous carbon for thermal energy storage
Authors: Pan Hong , Li Tianyang , Xu Lihui , Li Keting , Shen Yong , Ni Kai 
Published: September 2022

Abstract
This paper showed two bio-based shape-stable composite phase change materials which were prepared through a convenient vacuum impregnation method. Lignin-based ordered porous carbon (LOC) was the porous supporting material, polyethylene glycol (PEG) and paraffin (PA) was the phase change substance in this work. The maximum loading of PCMs in the obtained LOC/PEG and LOC/PA are 70% and 75%, respectively, and their phase transition enthalpy (ΔHm) are also as high as 81.5 J·g‒1 and 88.5 J·g‒1, respectively. In addition, the obtained LOC/PA showed better thermal management capabilities and better thermal stability after infrared thermography tests compared to LOC/PEG. Considering the low cost and excellent properties, the obtained lignin-based ordered porous carbon composite phase change material has a promising future for practical applications in thermal energy storage.
Usefulness of the Ultrasound Measurement of the Optic Nerve Sheath Diameter to Detect Intracranial Hypertension.
Authors: Yic Christian , Pontet Julio , Mercado Mauricio , Muñoz Matias , Biestro Alberto 
Published: September 2022

Abstract
Objectives:
To determine the predictive value of the measurement of the diameter of the optic nerve sheath (ONSD) with ocular ultrasonography compared to invasive intracranial pressure (ICP) measurement for the detection of intracranial hypertension (ICH).
Design: Prospective, observational study.
Setting: Intensive Care Unit (ICU) of two tertiary university hospitals in Montevideo, Uruguay.
Patients: We studied 56 adult patients of both sexes, over 18 years of age, who required sedation, mechanical ventilation, and invasive ICP monitoring (patients with severe, traumatic and non-traumatic AEI) with a Glascow Coma Score (GCS) equal to or less than 8 on admission to the ICU.
Interventions: This was a study that utilized non-invasive (minimal risk) ultrasonography in patients admitted to the ICU.
Measurements and main results: In our study, a logistic regression model was performed in which it was observed that the variable ONSD is statistically significant with a p value of 0.00803 (<0.05). This model estimates and predicts the probability that a patient will have an ICP greater than 20 mmHg.
From the analysis of the cut-off points, it is observed that a value of 5.65 mm of ONSD maximizes the sensitivity (92.9%) of the method (a greater number of individuals with ICP > 20 mmHg are correctly identified).
Conclusions: In sedated neurocritical patients, with structural Acute Brain Injury, the ONSD measurement strongly correlates with the ICP values measured invasively.
Security of medical information: Case study of the SMART2C system
Authors: DAASSA Asma , Ghannouchi Sonia Ayachi , Machhout Mohsen , Aguili Taoufik 
Published: September 2022

Abstract
In spite of the importance of security in process models, the domain of BPM and BPMS which stand for "Business Process Management" and "Business Process Management System", provide only little support for securing sensitive data. Nevertheless, privacy and confidentiality in BPMS solutions is still missing. This is particularly required for e-health applications. In this paper, we address the problem of privacy requirements and discuss data encryption approaches for personal information of patients and doctors in the database of a BPMS solutions in Intelligent assistance system for a COVID-19 crisis unit (SMART2C).
The natural capital of the Colombian Pacific basin. Challenges for a megadiverse region with little Government assistance
Authors: Agudelo Cesar Augusto Ruiz , Bonilla Francisco de Paula Gutierrez 
Published: September 2022

Abstract

The Pacific region is considered a biodiversity hotspot and presents high species endemic levels. The Colombian Pacific basin occupies an area of approx. eight million hectares, located in the country's west. The literature about the economic valuation of ecosystem services (ES) and the spatial information on natural resources in the Colombian Pacific basin was revised through various information sources to document the earliest approximation to the state, spatial distribution, and economic value of the natural capital at the scale of biomes, specific ecosystems, and political-administrative units. Our assessment estimated a natural capital loss of 40 billion Int.$2020/year (15% of Colombian GDP in 2020) and a remnant natural capital worth 139 billion Int.$2020/year (51% of Colombia's GDP in 2020) for 15 ecosystem services. This research establishes that a potential expansion in livestock production systems will generate an additional loss of natural capital between six and eight billion Int.$2020/year. Additionally, we include an analysis based on the GLOBIO4 initiative models, identifying future natural capital losses between 7.5 and 7.6 billion Int.$2020/year. Lastly, the policy challenges and gaps in research and management concerning this remaining natural capital in the Colombian Pacific basin are pointed out.
The Dietary Supplementation of Copper and Zinc Nanoparticles Improves Health Condition of Young Dairy Calves by Reducing the Incidence of Diarrhea and Boosting Immune Function and Antioxidant Activity
Authors: Pandey Pooja , Kumar Muneendra , Kumar Vinod , Kushwaha Raju , Vaswani Shalini , Kumar Avinash , Singh Yajuvendra , Shukla Pankaj Kumar 
Published: September 2022

AbstractThis study was conducted to evaluate the effect of nano copper (nano-Cu) and nano zinc (nano-Zn) supplementation on the biomarkers of immunityand antioxidant and health status attributes in young dairy calves. Twenty-four young cattle calves were randomly assigned into four groups (6 calves per group) on body weight and age basis for a period of 120 days. Feeding regimen was same in all the groups except that these were supplemented with 0.0 mg nano Cu and nano Zn (control), 10 mg nano Cu (nanoCu10), 32 mg nano Zn (nanoZn32) and combination of nano Cu and nano Zn (nanoCu10+nanoZn32) per kg dry matter (DM) basis in four respective groups. Supplementation of nano Cu along with nano Zn improves immune response which was evidenced from higher immunoglobulin G (IgG), immunoglobulin M (IgM), immunoglobulin A (IgA), total immunoglobulin (TIg) and Zn sulphate turbidity (ZST) units and lower plasma concentrations of tumour necrosis factor-α (TNF-α) and cortisol innanoCu10+nanoZn32group. There were no effect of treatment on the plasma concentrations of immunoglobulin E (IgE) and interferon gamma (IFN-γ). Antioxidant status was also better in thenanoCu10+nanoZn32group as evidenced from lower concentrations of malondialdehyde (MDA) and higher activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), ceruloplasmin (Cp) and total antioxidant status (TAS). However, treatment did not exert any effect on catalase (CAT) activity. Although the nano Cu or nano Zn supplementation, either alone or in combination, did not exert any effect on growth performance or body condition score (BCS) but frequency of diarrhea and incidence of diarrhea was lower while faecal consistency score (FCS) and attitude score were better in thenanoCu10+nanoZn32groups. In control group, one calves found affected with joint ill and two calves were found affected with navel ill. During the experimental period, none of the calf in all four groups was found affected with pneumonia. The findings of this study revealed that, dietary supplementation of nano Cu in combination with nano Zn improved the health status of young dairy calves by improving immunity and antioxidant status.
Long-term care needs and the risk of household poverty across Europe: A comparative secondary data study
Authors: Casanova Georgia , Lillini Roberto , Moreno Carolina , Lamura Giovanni 
Published: September 2022

Abstract
Population ageing and rising poverty are two of the most pressing issues today, even in Western European nations. In parallel, the risk of poverty is also growing as a result of the recent global economic crisis and the COVID-19 containment measures, which have reduced individual and collective productivity and had a negative impact on household income. This study intends to explore the relationship between long-term care (LTC) needs and the risk of poverty at the household level in eight European countries selected to represent the different care regimes in Europe.
The main international databases were scoured for study variables. These variables were categorized according to the following conceptual areas: home care, residential care, health expenditure, service coverage, cash benefits, private services, population, family, education, employment, poverty, disability and care recipients, and life expectancy. The statistical analyses were conducted as described hereafter: analysis of the Pearson’s Bivariate Correlation between the dependent variable and all other variables; a Multivariable Linear Regression Model between the Poverty Index (dependent variable) and the covariates identified in the preceding step; a check for geographical clustering effects and a reduced Multivariable Linear Regression Model for each identified European cluster.
The variables that addressed the risk of poverty pertained to the area of policy intervention and service provision (e.g., index of the service’s territorial coverage and the proportion of 65+ people receiving integrated home care).
Rising private out-of-pocket health expenditures and the proportion of “poor” couples with at least one child are two factors that contribute significantly to the rise in poverty.
The results of this study reveal the existence of a clear correlation between the need for LTC and the risk of poverty in households across Europe. These results highlight the central relevance of LTC policies, which are often still treated as marginal and sectoral, for the future sustainability of integrated care strategies.