bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corticosterone potentiates ochratoxin A-induced microglial activation
Authors: Chansawhang Anchana , Phochantachinda Sataporn , Temviriyanukul Piya , Chantong Boonrat 
Published: April 2022

Abstract
Microglial activation in the central nervous system (CNS) has been associated with brain damage and neurodegenerative disorders. Ochratoxin A (OTA) is a mycotoxin that occurs naturally in food and feed and has been associated with neurotoxicity, while corticosteroids are CNS’ physiological function modulators. This study examined how OTA affected microglia activation and how corticosteroids influenced microglial neuroinflammation. Murine microglial cells (BV-2) were stimulated by OTA, and the potentiation effects on OTA-induced inflammation were determined by corticosterone pre-treatment. Expressions of pro-inflammatory mediators including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and inducible nitric oxide synthase (iNOS) were determined. Phosphorylation of mitogen-activated protein kinases (MAPKs) was analyzed by western blotting. OTA significantly increased the mRNA expression of IL-6, TNF-α, IL-1β, and iNOS and also elevated IL-6 and NO levels. Corticosterone pre-treatment enhanced the neuroinflammatory response to OTA in a mineralocorticoid receptor (MR)-dependent mechanism, which is associated with increases in extracellular signal-regulated kinase (ERK) and p38 MAPK activation. In response to OTA, microglial cells produced pro-inflammatory cytokines and NO, while corticosterone increased OTA-induced ERK and p38 MAPK phosphorylation via MR. Findings indicated the direct role of OTA in microglia activation and neuroinflammatory response and suggested that low corticosterone concentrations in the brain exacerbated neurodegeneration.
Starlike and convexity properties ofq-Bessel-Struve functions
Authors: Oraby Karima M. , Mansour Zeinab S. I. 
Published: April 2022

AbstractThis paper introduces three different normalization associated with the second and thirdq-Bessel-Struve functions. We use Hadamard factorizations to determine the radii of starlike and convexity of these functions.
Coherent categorical structures for Lie bialgebras, Manin triples, classical r-matrices and pre-Lie algebras
Authors: Bai Chengming , Guo Li , Sheng Yunhe 
Published: April 2022

Abstract
The broadly applied notions of Lie bialgebras, Manin triples, classical r-matrices and

𝒪

{\mathcal{O}}

-operators of Lie algebras owe their importance to the close relationships among them.
Yet these notions and their correspondences are mostly understood as classes of objects and maps among the classes.
To gain categorical insight, this paper introduces, for each of the classes, a notion of homomorphisms, uniformly called coherent homomorphisms, so that the classes of objects become categories and the maps among the classes become functors or category equivalences. For this purpose, we start with the notion of an endo Lie algebra, consisting of a Lie algebra equipped with a Lie algebra endomorphism. We then generalize the above classical notions for Lie algebras to endo Lie algebras. As a result, we obtain the notion of coherent endomorphisms for each of the classes, which then generalizes to the notion of coherent homomorphisms by a polarization process. The coherent homomorphisms are compatible with the correspondences among the various constructions, as well as with the category of pre-Lie algebras.
On Deligne’s conjecture for symmetric fifth L-functions of modular forms
Authors: Chen Shih-Yu 
Published: April 2022

Abstract
We prove Deligne’s conjecture for symmetric fifth L-functions of elliptic newforms of weight greater than 5.
As a consequence, we establish period relations between motivic periods associated to an elliptic newform and the Betti–Whittaker periods of its symmetric cube functorial lift to

GL
4

{\operatorname{GL}_{4}}

.
On order of vanishing of characteristic elements
Authors: Lim Meng Fai 
Published: April 2022

AbstractLetpbe a fixed odd prime. LetEbe an elliptic curve defined over a number fieldFwith either good ordinary reduction or multiplicative reduction at each prime ofFabovep. We shall study the characteristic element of the Selmer group ofEover ap-adic Lie extension. In particular, we relate the order of vanishing of these characteristic elements evaluated at Artin representations to the Selmer coranks and their twists in the intermediate subextensions of thep-adic Lie extension.
On transitivity-like properties for torsion-free Abelian groups
Authors: Chekhlov Andrey R. , Danchev Peter V. , Keef Patrick W. 
Published: April 2022

Abstract
We study some close relationships between the classes of transitive, fully transitive and Krylov transitive torsion-free Abelian groups. In addition, as an application of the achieved assertions, we resolve some old-standing problems, posed by Krylov, Mikhalev and Tuganbaev in their monograph
[P. A. Krylov, A. V. Mikhalev and A. A. Tuganbaev,
Endomorphism Rings of Abelian Groups,
Kluwer Academic, Dordrecht, 2003].
Specifically, we answer Problem 44 from there in the affirmative by constructing a Krylov transitive torsion-free Abelian group which is neither fully transitive nor transitive. This extends to the torsion-free case certain similar results in the p-torsion case. We, alternatively, also expand to the torsion-free version some of the results concerning transitivity, full transitivity and Krylov transitivity in the p-primary case.
Equal/unequal half mode substrate integrated waveguide filtering power dividers using an ultra-compact metamaterial unit-cell
Authors: Danaeian Mostafa , Ghayoumi-Zadeh Hossein 
Published: April 2022

Abstract
In this paper, a novel ultra-compact metamaterial unit-cell is introduced. The proposed unit-cell consists of one modified rings which has been designed based on the fractal technique and meander technique. These techniques are used to reduce the physical size of the conventional complementary split ring resonators (CSRRs). In the proposed metamaterial unit-cell which is called the fractal/meander CSRR (FMCSRR), the slot lines in the conventional CSRRs are replaced by the fractal and meander slots, simultaneously. The FMCSRR unit-cell is a planar metamaterial element which exhibits negative permittivity and is considered as electric dipole when excited by an axial electric field. Thus, the FMCSRR unit-cell is modeled as a shunt resonator tank. Therefore, by using the proposed FMCSRR configuration, all of the interior space of the ring has been used and the slot lines have been increased. Consequently, the higher inductance has been achieved and the resonance frequency of the proposed FMCSRR unit-cell becomes lower compared with the conventional CSRR. That’s mean the electrical size of the introduced unit-cell FMCSRR unit-cell is smaller than the conventional CSRR with the same physical sizes. A microstrip notch band filter, a microstrip band-pass filter, a half mode substrate integrated waveguide (HMSIW) band-pass filter and three HMSIW filtering power dividers (FPDs) with different power division ratios of 1:1, 1:4, and 1:8 have been designed to illustrate the ability of the proposed FMCSRR unit-cell in the size reduction. All of the designed devices operated at 2.4 GHz which are suitable for WLAN applications. For verification the performance of the utilized techniques in miniaturization of the dimension, the designed equal/unequal HMSIW FPDs have been fabricated and tested. A reasonable agreement between simulated and measured results has been achieved. The results confirmation that a miniaturization about 79% has been obtained. The total size of the proposed HMSIW FPDs are about 0.09λ
g × 0.09λ
g. The proposed HMSIW FPDs have many advantages in terms of compact size, low insertion loss, high selectivity, easy integration with the other planar circuits, and controllable bandwidth.
Cytotoxicity of green-synthesized silver nanoparticles by Adansonia digitata fruit extract against HTC116 and SW480 human colon cancer cell lines
Authors: Almukaynizi Fatimah Basil , Daghestani Maha H. , Awad Manal A. , Althomali Arwa , Merghani Nada M. , Bukhari Wadha I. , Algahtani Norah M. , Al-Zuhairy Shatha S. , ALOthman Ahlam M. , Alsenani Eman A. , Alojayan Badrih O. , Al-Saif Khulud S. , Bhat Ramesa Shafi 
Published: April 2022

Abstract
Nanoparticles synthesized from plants are being explored for cancer treatment therapies all over the world. This study reported the eco-friendly and low-cost method for the green synthesis of silver nanoparticles (AgNPs) from Adansonia digitata fruit as a reducing and capping agent. The anti-cancer potential of synthesized particles was explored against HTC116 and SW480 colon cancer cell lines. Prepared AgNPs were characterized by ultraviolet-visible spectroscopy, zeta potential, transmission electronic microscopy, scanning electronic microscopy, Fourier transform infrared, and energy-dispersive spectrum. The cytotoxicity was determined with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and expression levels of four genes (CTNNB1, APC, LRP5, and LRP6) were checked by reverse transcription polymerase chain reaction. The sharp peak of surface plasmon resonance at 400 nm confirms the formation of AgNPs. Dynamic light scattering showed average sizes of 16.34 nm with a polydispersity index of 0.193. A. digitata AgNPs were spherical with slight aggregated. AgNPs were more cytotoxic than A. digitata extract and decrease the expression of CTNNB1 and LRP6 genes while LRP5 gene expression was increased in both cell lines. APC gene expression was decreased in SW480 but increased in HTC116 with treatment. Overall, this study suggested that AgNPs synthesized by A. digitata fruit extract can be an attractive candidate for anticancer applications.
The genetic elucidation of monogenic obesity in the Arab world: a systematic review
Authors: AbouHashem Nadien , Al-Shafai Kholoud , Al-Shafai Mashael 
Published: April 2022

Abstract

Background
Investigation of monogenic obesity (MO), a rare condition caused by a single gene variant(s), especially in consanguineous populations, is a powerful approach for obtaining novel insights into the genetic alterations involved. Here, we present a systematic review of the genetics of MO in the 22 Arab countries and apply protein modeling in silico to the missense variants reported.

Methods
We searched four literature databases (PubMed, Web of Science, Science Direct and Scopus) from the time of their first creation until December 2020, utilizing broad search terms to capture all genetic studies related to MO in the Arab countries. Only articles published in peer-reviewed journals involving subjects from at least one of the 22 Arab countries and dealing with genetic variants related to MO were included. Protein modelling of the variants identified was performed using PyMOL.

Results
The 30 cases with severe early-onset obesity identified in 13 studies carried 14 variants in five genes (LEP, LEPR, POMC, MC4R and CPE). All of these variants were pathogenic, homozygous and carried by members of consanguineous families.

Conclusion
Despite the elevated presence of consanguinity in the Arab countries, the genetic origins of MO remain largely unexplained and require additional studies, both of a genetic and functional character.
Clinical characteristics and genetics analysis for the ITD of congenital hypothyroidism
Authors: Gong Lifei , Yang Nan , Zhao Jinqi , Tang Yue , Li Lulu , Yang Haihe , Kong Yuanyuan 
Published: April 2022

Abstract

Objectives
Iodide transport defect (ITD) is one of the principal causes of congenital hypothyroidism (CH) and its primary molecular mechanism is a mutation of the sodium/iodide symporter (NIS) gene. This study aims to analyse the clinical characteristics and genetic mutations of ITD.

Methods
The participants were a pair of siblings diagnosed with congenital hypothyroidism. Inductively coupled plasma mass spectrometry was used to determine the concentration of salivary iodine and serum iodine and to calculate their ratio. At the same time, next-generation sequencing (NGS) was applied to detect all exons of congenital hypothyroidism-related genes. All suspicious variants were further validated in the patients and their parents by PCR and Sanger sequencing.

Results
Both patients were conclusively diagnosed with thyroid iodine transport defect (ITD). NGS identified two variants of the NIS gene in the siblings: c.1021G>A (p.Gly341Arg) with paternal origin and c.1330-2A>C with maternal origin. Both of these variants have not been reported to date. They are predicted to be pathogenic based on these clinical symptoms and comprehensive software analysis.

Conclusions
This is the first reported family study of congenital hypothyroidism with SLC5A5 mutation in China. Next-generation sequencing technology is an effective means of studying the genetics of congenital hypothyroidism. The therapeutic effect of potassium iodide needs to be further evaluated.
My lived reality and CSOE values of diversity, equity, and inclusion: interrogating the disconnect
Authors: Ukpokodu Omiunota Nelly 
Published: April 2022

Abstract
Colleges and Schools of Education (CSOE) often espouse and proclaim to embrace diversity, equity, and inclusion (DEI) and social justice, as the flagship of their programs and culture. Mission and vision statements and strategic goals are often anchored on these values and ideals. Yet, diversity, equity, inclusion, and social justice are often denied and elusive for Black, Indigenous, Faculty of Color (BIFOC), including African-Born Faculty of Color (ABFOC). In this article, using the lens of storied research and reflexivity, I examine my almost three-decades-long lived reality as an “othered” ABFOC in US CSOE. I specifically engage the questions: What has been my lived reality as an ABFOC in US CSOE that proclaims to value diversity, equity, and inclusion? And, how has my lived reality reflected CSOE professed values of DEI? I aim to interrogate and expose the disconnect between proclaimed values of DEI and my lived reality as an ABFOC in US COSE. I conclude the article by making a clarion call for disrupting the disconnect between institutional values and lived realities of ABFOC and other marginalized faculty groups.
Modulation of radiation-induced intestinal injury by radioprotective agents: a cellular and molecular perspectives
Authors: Meena Sunil Kumar , Joriya Pukha Raj , Yadav Sanwar Mal , Kumar Raj , Meena Priyadarshi , Patel Dev Dutt 
Published: April 2022

Abstract
The gastrointestinal (GI) system has rapidly proliferating and differentiating cells, which make it one of the most radiosensitive organs in the body. Exposure to high dose of ionising radiation (IR) during radiotherapy may generate a variety of reactive oxygen species (ROS) and reactive nitrogen species (RNS) including radicals, cause some side effects such as nausea, vomiting, diarrhoea, pain, ulceration, mal-absorption etc. Irradiation disrupts GI system by damaging proliferating stem cells of the crypts that alters the histology and physiology of intestine. Radiation damage reflects the qualitative and quantitative changes in intestinal epithelial stem cells like enterocytes, enteroendocrine cells, goblet cells and Paneth cells. The damaging effects of radiation to bio-molecules and cellular structures can alter gene signalling cascades and grounds genomic instability, protein modifications, cell senescence and cell death. The signalling pathways of GI tract includes Wnt, BMP, Hedgehog, PTEN/PI3K and Notch plays an important role in self-renewal of intestinal stem cells (ISCs) and maintaining the balance between self-renewal and differentiation of ISCs. Various radiation countermeasures including radioprotectors and mitigators are under development phase globally but still not approved for clinical applications during any radiation emergencies. In view of above, present review highlights cellular and molecular interruptions of GI system due to acute and chronic GI radiation injury, role of radioprotectors in signalling cascade modulations in GI epithelium and involvement of ISC markers in radioprotection.
Does Varying Resistance Exercises Promote Superior Muscle Hypertrophy and Strength Gains? A Systematic Review
Authors: Kassiano Witalo , Nunes João Pedro , Costa Bruna , Ribeiro Alex S. , Schoenfeld Brad J. , Cyrino Edilson S. 
Published: April 2022

Abstract
Kassiano, W, Nunes, JP, Costa, B, Ribeiro, AS, Schoenfeld, BJ, and Cyrino, ES. Does varying resistance exercises promote superior muscle hypertrophy and strength gains? A systematic review. J Strength Cond Res 36(6): 1753–1762, 2022—Fitness professionals routinely employ a variety of resistance training exercises in program design as a strategy to enhance muscular adaptations. However, it remains uncertain whether such an approach offers advantages over a fixed-exercise selection. The objective of this review was to review the effects of exercise variation on muscle hypertrophy and strength. A search of the literature was conducted using PubMed/MEDLINE, Scopus, and Web of Science databases. Eight studies were identified as meeting inclusion criteria. The combined total sample of the studies was N = 241, comprising all young men. The methodological quality of included studies was considered “good” and “excellent” based on the Physiotherapy Evidence Database Scale. The available studies indicate that varying exercise selection can influence muscle hypertrophy and strength gains. Some degree of systematic variation seems to enhance regional hypertrophic adaptations and maximize dynamic strength, whereas excessive, random variation may compromise muscular gains. We conclude that exercise variation should be approached systematically with a focus on applied anatomical and biomechanical constructs; on the contrary, employing different exercises that provide a redundant stimulus, as well as excessive rotation of different exercises (i.e., high frequency of change), may actually hinder muscular adaptations.
Effect of Seawater on the Mechanical Properties of PET Foam Sandwich Structure
Authors: Wang Yulin , Yang Bo , Zhu Houzhao , Peng Quansheng , Sun Xiaodan 
Published: April 2022

Abstract
The polyethylene terephthalate (PET) foam sandwich structure is widely used for ships and for studying the influence of the seawater environment on its mechanical properties as an important way to evaluate its safety performance. To study the effect of the seawater environment on the mechanical properties of the PET foam sandwich structure, this paper mainly studies the static properties, interlayer cracking properties, and fatigue failure properties of the PET foam sandwich structure under the simulated seawater environment at a constant temperature of 40°C. The compressive properties test, tensile properties test, three-point bending properties test, double cantilever beam test, and four-point test were carried out on PET foam specimens, glass fiber reinforced plastic (GFRP) panel specimens, and PET foam sandwich structure specimens with different immersion times. The multiphysics software COMSOL was used to model and analyze the mode I interlayer cracking properties of the PET foam sandwich structure. The comparative analysis of the experimental results shows that the seawater environment has an effect on the compression properties of PET foam, the tensile and flexural properties of GFRP panels, and the interlayer cracking properties of the PET foam sandwich structure, and as the immersion time is extended, the effect is more obvious. Seawater immersion can also lead to a reduction in the fatigue life and ultimate fatigue of the PET foam sandwich structure.
Hemodiyaliz Tedavisine Devam Eden Hastalarda Cilt Lezyonlarının Sıklığı ve İlişkili Faktörler: Tek Merkez Deneyimi
Authors: ALTUN Eda 
Published: April 2022

Amaç: Bu çalışmada diyaliz tedavi programındaki hastalarda cilt lezyonlarının sıklığını, cilt lezyonlarının tedavi süresi, diyaliz yeterliliği, altta yatan hastalık ile ilişkisinin varlığını saptamayı amaçladık.
Gereç ve Yöntemler: Çalışmaya 244 hemodiyaliz hastası dâhil edildi. Hastalar aylık muayeneleri yapılırken gönüllü dermatoloji uzmanı tarafından muayene edildi. Veriler dosyalarından retrospektif olarak kaydedildi.
Bulgular: Çalışmaya yaş ortalaması 58±18.2 olan 244 (%58 erkek, % 42 kadın) hasta alındı. Ortalama hemodiyaliz tedavi süresi 4.2 yıldı. En sık cilt bulgusu kserozis olup hastaların %60.6’sında mevcuttu. Diğer sık görülen cilt bulguları ise sıklık sırası ile pruritis (%53), kıllarda azalma (%49.5), saç değişiklikleri
(%47.9), tırnak değişiklikleri (%42.5), ekzema (%20.9) ve hiperpigmentasyon (%8.6) olarak saptandı. Kserozis sıklığı diyabetik hasta grubunda non-diyabetik hastalara göre daha fazlaydı (p
Effect of Home Visits by Nurses on the Physical and Psychosocial Health of Older Adults: A Systematic Review and Meta-Analysis
Authors: Ergin Emine , Akin Belgin , Kocoglu-Tanyer Deniz 
Published: April 2022

Background: One of the best ways to maintain and develop physical and psychosocial health is to make regular home visits. This meta-analysis aimed to determine (by subgroups) the effects of interventions based on nurses’ home visits on physical and psychological health outcomes of older people.
Methods: This search was carried out using the The CINAHL, Cochrane, MEDLINE, PubMed, Science Direct, Web of Science, and Turkish databases. Experimental and observational studies were included.
Results: The meta-analysis included 26 (with subgroups 50) out of 13110 studies. The minimum and maximum values of the effect size (Hedges g) were g = -0.708 and g = 0.525, respectively. The average effect size was g = 0.084 (SD = 0.21).
Conclusion: Home visit interventions are effective in reducing the frequency of hospitalization in the older adults, and improving physical and psychosocial health. They are negatively effective on falls and have no significant effect on the quality of life.
A Retrospective Study of Serum Calcium Status in Tehran, Iran (105,128 Samples, from 2009-2018)
Authors: Farhud Dariush D. , Zarif-Yeganeh Marjan , Mehrabi Atefeh , Afshari Ali-Reza , Rokni Mohammad Bagher , Majidi Keyvan , Jalali Maryam , Zargar Ali Akbar Amir , Sarafnejad Abdolfattah , Sadeghipour Hamid Reza , Zokaei Shaghayegh , Khosravi Farideh , Jalali Mahmoud , Khazeni Mohammad 
Published: April 2022

Background: Calcium is a necessary mineral for life to keep the body and bones healthy. Various factors including hormones, diet, age, and gender affect serum calcium status. The aim of this sturdy was to assess the serum calcium level (SCL) of Tehran population, which has about 10 million multi-Ethnic populations and represents from the whole country.
Methods: In this retrospective study, the measured SCL of 105,128 individuals referred to different laboratories of Tehran, Iran were evaluated and its relationship with the age, gender, seasons, and different years during 2009-2018, were analyzed.
Results: After excluding outliers, 91,257samples remained, which 61162 (58.64%) and 30,095 (41.36%) were female and male, respectively. The mean SCL was 9.36 (9.35, 9.37) mg/dl (95%CI). The highest and lowest SCLs were 3.1 and 18.2mg/dl, respectively. From the total study population, 74127 (81.23%) had normal SCLs, 14110 (15.46%) had hypocalcemia, and 3020 (3.31%) had hypercalcemia. SCLs were normal in 83.6% of men and 79.66% of women. Women had a significantly higher frequency of hypocalcemia compared to men (17.2% vs. 12.83%, p<0.0001).
Conclusion: Normal and abnormal SCLs were significantly different in age groups and in both genders. It means that gender and age affect SCLs. Every year of increasing age, reduces the chance of hypercalcemia by 40%, significantly. Age seems to affect hypercalcemia more than hypocalcemia. Age in men increases the risk of hypocalcemia, and reduces the risk of hypocalcemia in women. Therefore, it is recommended to encourage dietary calcium intake among premenopausal women and older men.