bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linked color imaging improves identification of early gastric cancer lesions by expert and non-expert endoscopists
Authors: Fockens Kiki , de Groof Jeroen , van der Putten Joost , Khurelbaatar Tsevelnorov , Fukuda Hisashi , Takezawa Takahito , Miura Yoshimasa , Osawa Hiroyuki , Yamamoto Hironori , Bergman Jacques 
Published: May 2022

Abstract
Background and aims
Early gastric cancer (EGC) lesions are often subtle and endoscopically poorly visible. The aim of this study is to evaluate the additive effect of linked color imaging (LCI) next to white-light endoscopy (WLE) for identification of EGC, when assessed by expert and non-expert endoscopists.

Methods
Forty EGC cases were visualized in corresponding WLE and LCI images. Endoscopists evaluated the cases in 3 assessment phases: Phase 1: WLE images only; Phase 2: LCI images only; Phase 3: WLE and LCI images side-to-side. First, 3 expert endoscopists delineated all cases. A high level of agreement between the expert delineations corresponded with a high AND/OR ratio. Subsequently, 62 non-experts indicated their preferred biopsy location. Outcomes of the study are as follows: (1) difference in expert AND/OR ratio; (2) accuracy of biopsy placement by non-expert endoscopists; and (3) preference of imaging modality by non-expert endoscopists.

Results
Quantitative agreement between experts increased significantly when LCI was available (0.58 vs. 0.46, p = 0.007). This increase was more apparent for the more challenging cases (0.21 vs. 0.47, p < 0.001). Non-experts placed the biopsy mark more accurately with LCI (82.3% vs. 87.2%, p < 0.001). Again this increase was more profound for the more challenging cases (70.4% vs. 83.4%, p < 0.001). Non-experts indicated to prefer LCI over WLE.

Conclusion
The addition of LCI next to WLE improves visualization of EGC. Experts reach higher consensus on discrimination between neoplasia and inflammation when using LCI. Non-experts improve their targeted biopsy placement with the use of LCI. LCI therefore appears to be a useful tool for identification of EGC.

Graphical abstract
Physical drivers of pelagic sargassum bloom interannual variability in the Central West Atlantic over 2010–2020
Authors: Skliris Nikolaos , Marsh Robert , Appeaning Addo Kwasi , Oxenford Hazel 
Published: May 2022

AbstractSince 2011, unprecedented pelagic sargassum seaweed blooms have occurred across the tropical North Atlantic, with severe socioeconomic impacts for coastal populations. To investigate the role of physical drivers in post-2010 sargassum blooms in the Central West Atlantic (CWA), conditions are examined across the wider tropical North Atlantic, using ocean and atmospheric re-analyses and satellite-derived datasets. Of particular consequence for the growth and drift of sargassum are patterns and seasonality of winds and currents. Results suggest that in years of exceptionally large sargassum blooms (2015, 2018), the Intertropical Convergence Zone (ITCZ), an area of maximum wind convergence where sargassum naturally accumulates, shifted southward, towards nutrient-rich waters of the Amazon River plume and the equatorial upwelling zone further stimulating sargassum growth. These changes are associated with modes of natural variability in the tropical Atlantic, notably a negative phase of the Atlantic Meridional Mode (AMM) in 2015 and 2018, and a positive phase of the Atlantic Niño in 2018. Negative AMM in these 2 years is also associated with stronger trade winds and enhanced northwest Africa upwelling, probably resulting in stronger southwestward nutrient transport into the eastern part of CWA. Moreover, in contrast with most years, important secondary winter blooms took place in both 2015 and 2018 in the northern part of CWA, associated with excessive wind-driven equatorial upwelling and anomalously strong northwestward nutrient transport.
Willmore surfaces and Hopf tori in homogeneous 3-manifolds
Authors: Albujer Alma L. , dos Santos Fábio R. 
Published: May 2022

AbstractSome classification results for closed surfaces in Berger spheres are presented. On the one hand, a Willmore functional for isometrically immersed surfaces into an homogeneous space $${\mathbb {E}}^{3}(\kappa ,\tau )$$

E

3

(
κ
,
τ
)

with isometry group of dimension 4 is defined and its first variational formula is computed. Then, we characterize Clifford and Hopf tori as the only Willmore surfaces satisfying a sharp Simons-type integral inequality. On the other hand, we also obtain some integral inequalities for closed surfaces with constant extrinsic curvature in $${\mathbb {E}}^3(\kappa ,\tau )$$

E

3

(
κ
,
τ
)

, becoming equalities if and only if the surface is a Hopf torus in a Berger sphere.
Survival of BRCA1/BRCA2-associated pT1 breast cancer patients, a cohort study
Authors: van Barele Mark , Rieborn Amy , Heemskerk-Gerritsen Bernadette A. M. , Obdeijn Inge-Marie , Koppert Linetta B. , Loo Claudette E. , Tollenaar Rob A. E. M. , Ausems Margreet G. E. M. , van de Beek Irma , Berger Lieke P. V. , de Boer Maaike , van Hest Liselot P. , Kets C. Marleen , Rookus Matti ,   Hebon, Schmidt Marjanka K. , Jager Agnes , Hooning Maartje J. 
Published: May 2022

Abstract
Purpose
Intensive screening in BRCA1/2 mutation carriers aims to improve breast cancer (BC) prognosis. Our aim is to clarify the prognostic impact of tumor size in BRCA mutation carriers with a pT1 BC, which is currently unclear. We are especially interested in differences between pT1a, pT1b, and pT1c regarding the prognosis of node-negative breast cancer, the effect of chemotherapy, and the prevalence of lymph node involvement.

Methods
For this study, BRCA1/2-associated BC patients were selected from a nationwide cohort. Primary outcomes were 10-year overall survival (OS) per pT1a-b-c group and the effect of chemotherapy on prognosis of node-negative BC, using Kaplan–Meier and Cox models. Finally, we evaluated lymph node involvement per pT1a-b-c group.

Results
963 women with pT1 BRCA1/2-associated BC diagnosed between 1990 and 2017 were included, of which 679 had pN0 BC. After a median follow-up of 10.5 years, 10-year OS in patients without chemotherapy was 77.1% in pT1cN0 and lower than for pT1aN0 (91.4%, p = 0.119) and pT1bN0 (90.8%, p = 0.024). OS was better with than without chemotherapy for pT1cN0 (91.6% vs. 77.1%, p = 0.001; hazard ratio (HR) 0.56, 95% confidence interval (CI): 0.21–1.48). Lymph node involvement was 24.9% in pT1c, 18.8% in pT1b, and 8.6% in pT1a.

Conclusion
Smaller tumor size is associated with better OS and less lymph node involvement in pT1 BRCA1/2-associated BC patients. The results suggest that early detection in BRCA1/2 mutation carriers of pT1a/b BC may reduce mortality and the need for systemic therapy.
Archaeology and Quality of Life in Central-European, Pre-Industrial Towns (Fourteenth to Eighteenth Centuries)
Authors: Piekalski Jerzy , Sawicki Jakub , Duma Paweł 
Published: May 2022

Abstract
Diversification of standards of living in modern societies is one of the main research topics for economists and sociologists. Usually, economic inequalities are considered to be a natural phenomenon which trigger further progress and, in moderate amounts, are socially acceptable. However, deep inequalities are unjust and destructive and lead to conflicts. The research of contemporary inequalities in living standards mainly focuses on defining their source and their social and economic implications. The issue of social inequalities in pre-industrial societies is researched in a similar way, but requires different methods and data sources. The purpose of this paper is to determine the usefulness of archaeology in the research of diversification of living standards in Central-European cities at the end of Middle Ages and in the Early Modern era. As a case study we discuss the consumption strategies of Late Medieval and Early Modern dress accessories from different burgher plots in Prague (modern Czech Republic) and Wrocław (modern Poland) as an introduction for broader research.
A Model of Transformational Learning for Early Childhood Community-based Workers: Sajag Training for Responsive Caregiving
Authors: Pearson Emma C. , Rawdin Clare , Ahuja Reema 
Published: May 2022

AbstractA global goal for early childhood education and care is to ensure universal, “quality” provision that reaches all children. Achieving this goal requires a well-prepared workforce that is equipped to adapt to and deliver early childhood programs across the vastly diverse contexts and communities where children are growing up around the world. Yet currently there is a severe shortage of early childhood workers, particularly in “low resource” and complex communities. Evidence to support appropriate training for such workers is also lacking. In response, this paper presents findings from a case study of a large-scale training program for community-based early childhood workers in central-east India. A total of 650 community-based Village Communicators were trained to deliver a responsive caregiving package to parents of young children. Data collected over 3 months highlight how the unique contextually grounded, caring and reflexive approach to training resulted in profound personal and professional change among training participants. The findings are of significance in informing policy and practice associated with global goals for early childhood. First, they challenge the technical, programmatic approaches to training that are commonly adopted for preparing this workforce. Second, they evidence the potentially transformative, long-term impact of person-centered approaches to training that facilitate knowledge-sharing to understand local needs and attitudes. Third, they provide insight into ways in which training programs can support enhanced local relevance and effectiveness of early childhood services implemented for children and families across diverse contexts.
Youth’s Experiences of the Devaluing of Their Contributions Due to Their Ethnicity and Gender
Authors: Fuligni Andrew J. , Smola Xochitl Arlene , Salek Samir Al 
Published: May 2022

AbstractThe message that one’s contributions are devalued can be a significant way that youth experience marginalization during the transition into adulthood. Participants (N = 298, Mage = 19.47 years, 51% female) reported having their ideas, opinions, and contributions being unwelcomed due to their ethnicity and gender. African American, Latinx, and Asian American young women indicated the most frequent devalued contributions. Devalued contributions due to ethnicity and gender were most strongly linked among these groups and Multiethnic youth than European American youth. Devalued contributions predicted depressive symptoms, feeling more needed and useful by society, and a greater sense of purpose beyond a traditional measure of discrimination. Assessing experiences of devalued contributions can provide a more thorough understanding of how marginalization shapes the transition to adulthood.
Electronic, optical, and mechanical properties of AlxIn1−xP alloys under temperature and pressure
Authors: Alfrnwani O. A. , Elkenany Elkenany B. , Degheidy A. R. 
Published: May 2022

AbstractIn this work, the optoelectronic and mechanical properties of AlxIn1−xP combinations in the zinc-blende structure were studied for different Al concentrations. The energy band gaps$$\left( {{\text{E}}_{{\text{g}}}^{{\text{L}}} ,\,{\text{E}}_{{\text{g}}}^{\Gamma } ,\,{\text{E}}_{{\text{g}}}^{{\text{X}}} } \right)$$EgL,EgΓ,EgX, refractive index (n), high frequency and static dielectric constants (ɛ∞, ɛo), elastic parameters (C11, C12, C44) were investigated. Other mechanical properties such as bulk (Bu), shear (Cs), Young’s (Y0) moduli, Poisson ratio (σ), linear compressibility$$(C_{o} )$$(Co), Cauchy$$(C_{a} )$$(Ca)ratio, isotropy factor (A), bond stretching parameter$$(\alpha \,)$$(α), bond-bending force parameter$$(\beta \,)$$(β), internal-strain parameter$$(\xi )$$(ξ), and the transverse effective charge$$(e_{T}^{*} )$$(eT∗)were calculated. Also, the temperature and pressure dependences of these properties were studied. Our estimations were made with the empirical pseudo-potential method combined with the virtual crystal approximation incorporated the compositional disorder impact. There was a reasonable agreement between our determined outcomes and the accessible experimental values for the binary materials AlP and InP which give help for the consequences of the ternary combinations.
Infinite frequency principles of direct inference
Authors: Ackermans Lennart B. 
Published: May 2022

AbstractAccording to an infinite frequency principle, it is rational, under certain conditions, to set your credence in an outcome to the limiting frequency of that outcome if the experiment were repeated indefinitely. I argue that most infinite frequency principles are undesirable in at least one of the following ways: (1) accepting the principle would lead you to accept bets with sure losses, (2) the principle gives no guidance in the case of deterministic experiments like coin tosses and (3) the principle relies on a metaphysical property, ‘chanciness’, whose necessary and sufficient conditions are unknown. I show that a frequency principle that is based on the principal principle suffers from problems related to the definition of ‘chance’ or ‘chanciness’, which could lead to all three of the above problems. I introduce a version of the infinite frequency principle that does not rely on a notion of chance or chanciness and does not suffer from any of these problems.
Anti-exceptionalism and methodological pluralism in logic
Authors: Tajer Diego 
Published: May 2022

AbstractAccording to methodological anti-exceptionalism, logic follows a scientific methodology. There has been some discussion about which methodology logic has. Authors such as Priest, Hjortland and Williamson have argued that logic can be characterized by an abductive methodology. We choose the logical theory that behaves better under a set of epistemic criteria (such as fit to data, simplicity, fruitfulness, or consistency). In this paper, I analyze some important discussions in the philosophy of logic (intuitionism versus classical logic, semantic paradoxes, and the meaning of conditionals), and I show that they presuppose different methodologies, involving different notions of evidence and different epistemic values. I argue that, rather than having a specific methodology such as abductivism, logic can be characterized by methodological pluralism. This position can also be seen as the application of scientific pluralism to the realm of logic.
Leveraging Blur Information for Plenoptic Camera Calibration
Authors: Labussière Mathieu , Teulière Céline , Bernardin Frédéric , Ait-Aider Omar 
Published: May 2022

AbstractThis paper presents a novel calibration algorithm for plenoptic cameras, especially the multi-focus configuration, where several types of micro-lenses are used, using raw images only. Current calibration methods rely on simplified projection models, use features from reconstructed images, or require separated calibrations for each type of micro-lens. In the multi-focus configuration, the same part of a scene will demonstrate different amounts of blur according to the micro-lens focal length. Usually, only micro-images with the smallest amount of blur are used. In order to exploit all available data, we propose to explicitly model the defocus blur in a new camera model with the help of our newly introduced Blur Aware Plenoptic (BAP) feature. First, it is used in a pre-calibration step that retrieves initial camera parameters, and second, to express a new cost function to be minimized in our single optimization process. Third, it is exploited to calibrate the relative blur between micro-images. It links the geometric blur, i.e., the blur circle, to the physical blur, i.e., the point spread function. Finally, we use the resulting blur profile to characterize the camera’s depth of field. Quantitative evaluations in controlled environment on real-world data demonstrate the effectiveness of our calibrations.
Supporting reflection to improve learning from self-generated concept maps
Authors: Eshuis Elise H. , ter Vrugte Judith , de Jong Ton 
Published: May 2022

AbstractCreating concept maps is considered to be a powerful means for learning. It requires students to systematically organize and integrate their knowledge, which can foster meaningful learning. However, students scarcely spontaneously engage in the (meta)cognitive processes necessary for effective knowledge integration, such as reflection, which can hamper the effectiveness of concept mapping for learning. This study explores the effect of additional support that stimulates reflection by means of expert examples, reflection prompts, and classroom discussion. First-year technical vocational students (N = 144, Mage = 17.5 years) studied electricity-related topics in an online learning environment and created concept maps about their knowledge. Students’ concept maps were supplemented with either (1) no support (control condition), (2) an expert example (a combined concept map, containing their own and an expert example concept map, with differences highlighted), (3) an expert example and reflection prompts students had to process individually, (4) an expert example and reflection prompts students had to process individually after a teacher-guided classroom discussion. Students in the classroom discussion condition showed higher learning gains compared to all other conditions. This can be explained by the quality of their reflection, which proved to be a significant predictor of learning gain.
Intraperitoneal Instillation of Local Anesthetic (IPILA) in Bariatric Surgery and the Effect on Post-operative Pain Scores: a Randomized Control Trial
Authors: Kaur Ramandeep , Seal Alexa , Lemech Igor , Fisher Oliver M. , Williams Nicholas 
Published: May 2022

Abstract
Background
Effective analgesia after bariatric procedures is vital as it can reduce post-operative opioid use. This leads to less nausea which may be associated with shorter post-operative length of stay (LOS). Understanding analgesic requirements in patients with obesity is important due to the varied physiology and increased number of comorbidities.

Objectives
The aim of this study was to evaluate the efficacy of intraperitoneal instillation of local anesthetic (IPILA) to reduce opioid requirements in patients undergoing laparoscopic bariatric surgery.

Methods
A double-blinded randomized control trial was conducted to compare intraperitoneal instillation of ropivacaine to normal saline in 104 patients undergoing bariatric surgery. The primary endpoint was pain in recovery with secondary endpoints at 1, 2, 4, 6, 24, and 48 h post-operatively. Further endpoints were post-operative analgesic use and LOS. Safety endpoints included unexpected reoperation or readmission, complications, and mortality.

Results
There were 54 patients in the placebo arm and 50 in the IPILA. Pain scores were significantly lower in the IPILA group both at rest (p = 0.04) and on movement (p = 0.02) in recovery with no difference seen at subsequent time points. Equally, IPILA was independently associated with reducing severe post-operative pain at rest and movement (adjusted odds ratio [aOR] 0.28, 95% CI 0.11–0.69, p = 0.007 and aOR 0.25, 95% CI 0.09–0.62, p = 0.004, respectively). There was no significant difference in LOS, opioid use, antiemetic use, morbidity, or mortality between the intervention and placebo groups.

Conclusion
The administration of ropivacaine intraperitoneally during laparoscopic bariatric surgery reduces post-operative pain in the recovery room but does not reduce opioid use nor LOS.
Copula-based bivariate finite mixture regression models with an application for insurance claim count data
Authors: Bermúdez Lluís , Karlis Dimitris 
Published: May 2022

AbstractModeling bivariate (or multivariate) count data has received increased interest in recent years. The aim is to model the number of different but correlated counts taking into account covariate information. Bivariate Poisson regression models based on the shock model approach are widely used because of their simple form and interpretation. However, these models do not allow for overdispersion or negative correlation, and thus, other models have been proposed in the literature to avoid these limitations. The present paper proposes copula-based bivariate finite mixture of regression models. These models offer some advantages since they have all the benefits of a finite mixture, allowing for unobserved heterogeneity and clustering effects, while the copula-based derivation can produce more flexible structures, including negative correlations and regressors. In this paper, the new approach is defined, estimation through an EM algorithm is presented, and then different models are applied to a Spanish insurance claim count database.
Is the Sex Difference a Clue to the Pathomechanism of Dry Eye Disease? Watch out for the NGF-TrkA-Piezo2 Signaling Axis and the Piezo2 Channelopathy
Authors: Sonkodi Balázs , Resch Miklós D. , Hortobágyi Tibor 
Published: May 2022

AbstractDry eye disease (DED) is a multifactorial disorder with recognized pathology, but not entirely known pathomechanism. It is suggested to represent a continuum with neuropathic corneal pain with the paradox that DED is a pain-free disease in most cases, although it is regarded as a pain condition. The current paper puts into perspective that one gateway from physiology to pathophysiology could be a Piezo2 channelopathy, opening the pathway to a potentially quad-phasic non-contact injury mechanism on a multifactorial basis and with a heterogeneous clinical picture. The primary non-contact injury phase could be the pain-free microinjury of the Piezo2 ion channel at the corneal somatosensory nerve terminal. The secondary non-contact injury phase involves harsher corneal tissue damage with C-fiber contribution due to the lost or inadequate intimate cross-talk between somatosensory Piezo2 and peripheral Piezo1. The third injury phase of this non-contact injury is the neuronal sensitization process with underlying repeated re-injury of the Piezo2, leading to the proposed chronic channelopathy. Notably, sensitization may evolve in certain cases in the absence of the second injury phase. Finally, the quadric injury phase is the lingering low-grade neuroinflammation associated with aging, called inflammaging. This quadric phase could clinically initiate or augment DED, explaining why increasing age is a risk factor. We highlight the potential role of the NGF-TrkA axis as a signaling mechanism that could further promote the microinjury of the corneal Piezo2 in a stress-derived hyperexcited state. The NGF-TrkA-Piezo2 axis might explain why female sex represents a risk factor for DED.