bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parenting Children with Cystic Fibrosis: Developmental Acquisition of Expertise
Authors: Tluczek Audrey , Grob Rachel , Warne Emily , Van Gorp Stacy , Greene Lisa , Homa Karen 
Published: May 2022

ABSTRACT:

Objective:
This study was designed to increase our understanding of parents' experiences managing the needs of their children with cystic fibrosis (CF) and to identify potential gaps in services.

Method:
We used grounded dimensional analysis of anonymous survey data obtained from a quality improvement initiative conducted by the Cystic Fibrosis Foundation (CFF). The Patient and Family Experience of Care (PFEC) survey was administered continuously at 125 CF care centers throughout the United States in 2017. The subsample of data for this study was completed by 80 parents/caregivers of children with CF (younger than 18 years).

Results:
Two unifying themes emerged from parents' survey responses: (1) parents' expertise expands continually as they learn and adapt to changes in their children's maturity or health and (2) parental expertise is sometimes visible or invisible to clinicians. Parents' expertise evolved with their children's development. Visible to care teams was at-home care, e.g., respiratory treatments and medications. Less visible were intangible management activities, e.g., social processes, emotions, and concerns that were omnipresent for parents but seldom disclosed to or seen/recognized by clinicians. Themes, such as the quality of encounters with care teams, progressive nature of CF, and hope derived from advances in research, were associated with specific contextual factors.

Conclusion:
The findings expand our understanding of lived parental experiences of CF across childhood and offer direction for future quality improvement and research. Online parent surveys offer a valuable tool to identify unmet needs across subgroups of families affected by chronic childhood health conditions.
Cheek Donor Site for Full-Thickness Skin Graft Repair of the Nasal Ala: Outcomes of a Retrospective Cohort Study
Authors: Du Eric Y. , Moody Rylee A. , Armbrecht Eric S. , Chen Collin L. , Maher Ian A. , Bernstein Michael L. , Behshad Ramona 
Published: May 2022

BACKGROUND
Full-thickness skin grafts (FTSGs) are useful repairs for reconstructing nasal alar defects. Traditional donor sites include the preauricular, postauricular, and supraclavicular skin.

OBJECTIVE
To evaluate esthetic outcomes and complications of nasal alar defects repaired with FTSGs from the medial cheek.

MATERIALS AND METHODS
A retrospective chart review of Mohs surgery patients who had FTSG repair of the nasal ala between January 2015 and August 2020 was performed. Demographic, surgery, and follow-up visit data were reviewed. Cosmesis was rated by a facial plastic surgeon, a Mohs surgeon, and a plastic surgeon using baseline, defect, and follow-up visit photographs.

RESULTS
Sixty-nine patients with FTSG repairs of nasal alar defects were identified. 51 of 69 patients (73.9%) had the cheek donor site, and 18 of 69 patients (26.1%) had a noncheek donor site. The mean (SD) rater visual analog score for both cohorts was good with no significant difference (cheek: 65.9 [13.8]; noncheek: 66.1 [15.3]; p = .96). A notable difference in the complication rate by donor site was observed (cheek: 6.9%, noncheek: 16.7%; p = .13), although it did not reach significance.

CONCLUSION
The cheek is a reliable FTSG donor site for nasal alar defects after Mohs micrographic surgery, with a trend toward fewer complications.
Reliability and responsivity of pain intensity scales in individuals with chronic pain
Authors: Euasobhon Pramote , Atisook Raviwon , Bumrungchatudom Kulsiri , Zinboonyahgoon Nantthasorn , Saisavoey Nattha , Jensen Mark P. 
Published: May 2022

Abstract
Prior research supports the validity and short-term test–retest stability of 4 commonly used scales for assessing pain intensity (Visual Analogue Scale [VAS], 6-point Verbal Rating Scale [VRS-6], Numerical Rating Scale [NRS-11], and Face Pain Scale-Revised [FPS-R]). However, the relative stability and ability of these measures to detect changes in pain intensity over longer time periods have not yet been examined, although knowledge regarding these psychometric issues is important for selecting from among these measures. To address this knowledge gap, we administered these scales assessing worst and average pain intensity to 250 chronic pain outpatients on 2 occasions, a little over 6 weeks apart on average. All 4 scales were found to be valid for detecting decreases in pain, and the VAS, NRS-11, and FPS-R evidenced the most validity for detecting increases in pain. The NRS-11 and VAS evidenced better test–retest stability than the VRS-6 and FPS-R. Age affected the ability of the VRS-6 for detecting improvement in worst pain, as well as the ability of the VAS for detecting worsening in both worst and average pain. However, the psychometric properties of the scales were not influenced by education level. Overall, the NRS-11 emerged as showing the most sensitivity and stability. The FPS-R seems to be a good second choice to consider for samples of individuals who might have difficulty understanding or using the NRS-11.
Prevalence and Characterization of Undiagnosed Youths at Risk of Chlamydia trachomatis Infection: A Cross-sectional Study
Authors: Reyes-Lacalle Azahara , Carnicer-Pont Dolors , Masvidal Miriam Gómez , Montero-Pons Laura , Cabedo-Ferreiro Rosa , Falguera-Puig Gemma 
Published: May 2022

Objective
The aim of this study was to determine the prevalence of Chlamydia trachomatis infection in undiagnosed young people aged between 15 and 24 years.

Materials and Methods
A convenience sample of 623 youths, with a mean (SD) age of 20.1 (2.2) years, was recruited from key spaces in the North Metropolitan area of Barcelona in Catalonia, Spain. Participants completed a 21-item questionnaire and provided a urine sample or vaginal swab for testing.

Results
The most common age at the first sexual intercourse was 16 years (24.6%), followed by 15 years (21.3%). Only 32.6% reported always use of condoms, 49.2% sometimes, and 15.6% never. A positive test for chlamydia was found in 34 participants (5.5%; 95% CI, 3.8–7.5), with no difference by sex. A positive test was significantly more common among the participants who were working, who had been diagnosed with a sexually transmitted disease (STD) at some point in their life, and who used web pages/apps to find new sexual partners more than once a month. In the multivariate analysis, working status was an independent factor associated with chlamydial infection (adjusted odds ratio[OR], 8.88; 95% CI, 1.71–46.17), whereas not having been previously diagnosed with an STD (OR, 0.34; 95% CI, 0.07–1.49) and never using the Internet to find sexual partners (OR, 0.16; 95% CI, 0.03–080) were protective factors against chlamydial infection.

Conclusions
The prevalence of C. trachomatis infection was 5.5%. Working status, a previous diagnosis of STD, and use of the Internet to find new sexual partners were associated with chlamydial test positivity.
Comparison of efficacy and safety of traditional Chinese patent medicines for diabetic nephropathy
Authors: Liu Shilin , Li Andong , Jiang Bin , Mi Jia , Nan Hongmei , Bao Pengjie , Nan Zheng 
Published: May 2022

Abstract

Background:
Diabetic nephropathy (DN) is one of the most serious complications of diabetes. It has become a global public health problem among humans. DN is the leading cause of end-stage renal disease. At present, there is no specific medicine or modern medicinal therapy. In recent years, studies have shown that traditional Chinese patent medicines have been effective in treating DN, with few side effects. There is no systematic review on the treatment of DN with Chinese patent medicines. The current systematic review aims to evaluate the efficacy and safety of Chinese patent medicines for the treatment of DN.

Methods:
We will develop a search strategy to search major Chinese and English databases from inception to February 25, 2022 for randomized controlled trials examining the use of traditional Chinese patent medicine for the treatment of DN. The search will be conducted in accordance with the participants, interventions, comparisons, outcomes (PICOS) framework. Two researchers will use EndnoteX9 software to extract data and independently evaluate the quality of the included trials. Finally, the Bayesian network meta-analysis will be carried out by using software such as ReviewManager, Stata16.0, and WinBUGS1.4.3.

Results:
The primary outcomes will be urine albumin excretion rate, urea nitrogen, serum creatinine, total effective rate, and adverse events, and the secondary outcomes will be body mass index, fasting blood glucose, and 2-hPG during 75-g OGTT. These outcomes will be examined to provide a reliable basis for the treatment of DN with different traditional Chinese patent medicines.

Conclusion:
This review will compare the efficacy and safety of different traditional Chinese patent medicines for treating DN. The results of the study will provide a basis for the selection of adjuvant treatment options for DN.
Case report of Modified Viabahn Open Revascularization TEChnique (VORTEC) as a rescue strategy for hepatic artery dissection after initial endovascular treatment of postpancreaticoduodenectomy hemorrhage
Authors: Sng Yi Ping , Li Zhihao , Yen Hsu-Ting , Yong Chee Chien 
Published: May 2022

Abstract

Rationale:
Currently endovascular treatments are commonly utilized to treat postpancreaticoduodenectomy hemorrhage. However, when endovascular procedure went wrong, open surgery with ligation of the culprit vessels would be the most common salvage method. With Modified Viabahn Open Revascularization TEChnique (VORTEC), we can try to rescue the vessel without sacrificing it by introduction of another endovascular stent under direct method.

Patient concerns:
A 76-year-old man with stage IIIA ampulla vater adenocarcinoma underwent pancreaticoduodenectomy and experience pancreatic leak complicated with postpancreaticoduodenectomy hemorrhage.

Diagnosis:
Emergent angiography revealed extravasation from proper hepatic artery.

Interventions:
A 6 mm Viabahn stent was deployed but no distal runoff. Operation was shifted to emergent laparotomy and revealed intimal dissection of hepatic artery. Modified VORTEC was performed with guidewire redirected to true lumen and another stent was deployed under direct vision.

Outcomes:
Patient's hepatic artery was preserved and with no consequent liver failure.

Lesson:
Modified VORTEC method could be used as salvage strategy for artery dissection after initial endovascular treatment failed.
CT findings of basaloid squamous cell carcinoma of the lung in 12 patients
Authors: Kim Chu Hyun , Cha Yoon Ki , Han Joungho , Kim Jun Ho , Kim Tae Jung , Chung Myung Jin , Lee Jung Hee , Yoon Hyun Jung 
Published: May 2022

Abstract
Basaloid squamous cell carcinoma (SCC) is very rare subtype of SCC of the lung and it is important to distinguish basaloid to other subtypes of SCCs, since the prognosis of basaloid subtype is considered poorer than that of other non-basaloid subtypes of SCCs. Aim of this study was to assess computed tomography (CT) findings of basaloid SCC of the lung in 12 patients.
From January 2016 to April 2021, 12 patients with surgically proven basaloid SCC of the lung were identified. CT findings were analyzed, and the imaging features were compared with histopathologic reports. Clinical and demographic features were also analyzed.
Axial location of the tumor was central in 5 patients, while 7 was in peripheral. Of the 7 patients whose tumors were located in the peripheral, margin of the tumor were smooth (n
= 2), lobulated (n
= 2), or spiculated (n
= 3). After contrast injection, net enhancement value ranged from 15.8 to 71.8 HU (median, 36.4 HU). Endobronchial growth were seen in 5 patients and these patients accompanied obstructive pneumonia or atelectasis. Internal profuse necrosis, cavitation, or calcifications were not seen.
On CT, basaloid squamous cell presents as solitary nodule or mass with moderate enhancement. Tumor was located either peripheral or central compartment of the lung and cavitation was absent.
Preliminary evaluation of a small interfering RNA molecular probe targeting murine double minute 2 in breast cancer
Authors: Wang Xinyu , Xu Peng , Jiao Yuying , Luan Sha , Gao Yue , Zhao Changjiu , Fu Peng 
Published: May 2022

Introduction
Murine double minute 2 (MDM2) is an oncogene that is important in tumorigenesis, tumor metastasis and chemotherapy resistance. We aimed to synthesize a molecular imaging probe, 99mTc-HYNIC-siRNA 1489, which could specifically bind to MDM2. The [99mTc]HYNIC-siRNA 1489 molecular probe provided an effective way of assessing MDM2 expression via single-photon emission computed tomography.

Method
Three siRNAs were designed, and their inhibitory efficiencies were determined using western blots and qRT-PCR. The selected siRNA was labeled with the radionuclide technetium-99m (99mTc) through the chelator HYNIC. The bioactivity and properties of [99mTc]HYNIC-siRNA 1489 were evaluated prior to imaging in mice. Imaging and biodistribution of the probe were used to assess its targeting ability.

Results
SiRNA 1489, which was labeled with 99mTc, displayed a strong inhibitory effect in Michigan Cancer Foundation-7 cell lines. The radiochemical purity of [99mTc]HYNIC-siRNA 1489 was stable at various temperatures in phosphate-buffered serum and bovine serum. The tumor/muscle ratio in mice injected with [99mTc]HYNIC-siRNA 1489 was higher than that in those injected with the negative control, [99mTc]HYNIC-NC siRNA. The percentage injected dose per gram (%ID/g) of the tumors injected with 99mTc-HYNIC-siRNA 1489 was greater than that of the control group.

Conclusion
The [99mTc]HYNIC-siRNA 1489 was taken up by the tumor, which had a high level of MDM2. The probe exhibited a sufficient retention time in the tumor. This probe may be an effective strategy for evaluating MDM2 expression and achieving early diagnosis in breast cancer.
Dissertation Topics in Nursing
Authors: Dieckmann Nathan F. , Stoyles Sydnee A. , Aebischer Jonathan H. , Olvera-Alvarez Hector A. 
Published: May 2022

Background
Few quantitative studies have documented the types of research topics most commonly employed by nursing PhD students and whether they differ by program delivery (in-person vs. online/hybrid programs).

Objectives
We examined a large set of publicly available PhD dissertation abstracts to (a) describe the relative prevalence of different research topics and methods and (b) test whether the primary topics and methods used differed between online or hybrid and in-person PhD programs. A secondary goal was to introduce the reader to modern text-mining approaches to generate insights from a document corpus.

Methods
Our database consisted of 2,027 dissertation abstracts published between 2015 and 2019. We used a structural topic modeling text-mining approach to explore PhD students’ research topics and methods in United States-based doctoral nursing programs.

Results
We identified 24 different research topics representing a wide range of research activities. Most of the research topics identified did not differ in prevalence between online/hybrid and in-person programs. However, online/hybrid programs were more likely to engage students in research focused on nursing education, professional development, work environment, simulation, and qualitative analysis. Pediatrics, sleep science, older adults and aging, and chronic disease management were more prevalent topics in in-person-only programs.

Discussion
The range of topics identified highlights the breadth of research nursing PhD students’ conduct. Both in-person and online/hybrid programs offer a range of research opportunities, although we did observe some differences in topic prevalence. These differences could be due to the nature of some types of research (e.g., research that requires an in-person presence) or differences in research intensity between programs (e.g., amount of grant funding or proximity to a medical center). Future research should explore why research topic prevalence may vary by program delivery. We hope that this text-mining application serves as an illustrative example for researchers considering how to draw inferences from large sets of text documents. We are particularly interested in seeing future work that might combine traditional qualitative approaches and large-scale text mining to leverage the advantages of each.
Serum Ascorbic Acid and Thiamine Concentrations in Sepsis: Secondary Analysis of the Swiss Pediatric Sepsis Study
Authors: Equey Lucile , Agyeman Philipp K. A. , Veraguth Rosemarie , Rezzi Serge , Schlapbach Luregn J. , Giannoni Eric ,   for the Swiss Pediatric Sepsis Study Group
Published: May 2022

OBJECTIVES:
To determine circulating levels of ascorbic acid (VitC) and thiamine (VitB1) in neonates and children with blood culture-proven sepsis.

DESIGN:
Nested single-center study of neonates and children prospectively included in the Swiss Pediatric Sepsis Study.

SETTING:
One tertiary care academic hospital.

PATIENTS:
Sixty-one neonates and children 0–16 years old.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
VitC and VitB1 were quantified in serum of patients (median age, 10.5 mo; interquartile range [IQR], 0.5–62.1 mo) with blood culture-proven sepsis. Median time between sepsis onset and sampling for measurement of vitamins was 3 days (IQR, 2–4 d). Median serum levels of VitC and VitB1 were 32.4 μmol/L (18.9–53.3 μmol/L) and 22.5 nmol/L (12.6–82 nmol/L); 36% of the patients (22/61) had low VitC and 10% (6/61) had VitC deficiency; and 72% (44/61) had low VitB1 and 13% (8/61) had VitB1 deficiency. Children with low VitC were older (p = 0.007) and had higher C-reactive protein (p = 0.004) compared with children with VitC within the normal range. Children with low VitB1 levels were older (p = 0.0009) and were less frequently receiving enteral or parenteral vitamin supplementation (p = 0.0000003) compared with children with normal VitB1 levels.

CONCLUSIONS:
In this cohort of newborns and children with sepsis, low and deficient VitC and VitB1 levels were frequently observed. Age, systemic inflammation, and vitamin supplementation were associated with vitamin levels during sepsis.
Vitamin C Deficiency in Critically Ill Children: Prospective Observational Cohort Study
Authors: Fathi Alireza , Downey Corcoran , Rabiee Gohar Aida 
Published: May 2022

OBJECTIVES:
To evaluate the presence of vitamin C deficiency in critically ill children admitted to the PICU.

DESIGN:
Single-center prospective observational cohort study.

SETTING:
A 28-bed PICU and a pediatric outpatient sedation room of a tertiary-care teaching hospital.

PATIENTS:
Two pediatric patient groups 0–21 years old were studied: a PICU group and a group receiving deep sedation for elective outpatient procedures (noncritical care group).

INTERVENTIONS:
Vitamin C level was drawn for the PICU group within 24 hours of admission. Vitamin C level was drawn prior to start of deep sedation for the noncritical group.

Measurement and Main Results:
Vitamin C deficiency was present in 11/60 (18%) in the PICU group and 0/21 (0%) of the noncritical group (p < 0.05).

CONCLUSIONS:
Vitamin C deficiency was prevalent in our patients admitted to PICU.
Semiautomated Regional Citrate Anticoagulation for Continuous Kidney Replacement Therapy: An Observational Study in Young Children
Authors: Liet Jean-Michel , Baleine Julien , Demaret Pierre , Mounier Sophie , Porcheret Florence , Joram Nicolas , Chenouard Alexis 
Published: May 2022

OBJECTIVES:
To review use of semiautomated regional citrate anticoagulation (saRCA) for continuous kidney replacement therapy (CKRT) in young children.

DESIGN:
Retrospective cohort study.

SETTING:
Three independent PICUs.

PATIENTS:
All consecutive children weighing less than 11 kg who received CKRT with saRCA from January 2015 to June 2020.

INTERVENTIONS:
None.

MEASUREMENTS and MAIN RESULTS:
Twenty-one children weighing less than 11 kg underwent CKRT with saRCA. The total duration of the CKRT was 2,014 hours, with a total of 64 CKRT sessions. Citrate intoxication occurred in four of 64 CKRT sessions (6%). Citrate intoxication was consistently observed in the few CKRT sessions where the initial lactate concentration was greater than 4 mmol/L or the ratio of replacement fluid flow to citrate flow less than 50%. The rate of unscheduled interruptions of CKRT sessions was 25% (16/64).

CONCLUSIONS:
We have used saRCA for CKRT in children weighing less than 11 kg. A strict protocol and intensive training are required to minimize complications.
Long-term effectiveness and safety of medical cannabis administered through the metered-dose Syqe Inhaler
Authors: Aviram Joshua , Atzmony Daniella , Eisenberg Elon 
Published: May 2022

Abstract

Introduction:
Preliminary clinical studies on medical cannabis (MC) treatment using the Syqe Inhaler showed short-term effectiveness and safety at very low and precise doses of MC.

Objectives:
Here, we retrospectively analyzed “real-life” long-term data collected in real time on the potential effectiveness and safety of MC administered with this device.

Methods:
Patients were monitored by Syqe's patient support program. (−)-Δ9-trans-Tetrahydrocannabinol (Δ9-THC) served as a dosage marker for full-spectrum MC. Pain intensity was evaluated using a numeric pain scale (NPS) from baseline to 120 days after treatment initiation. The change in quality of life (QoL) from baseline was evaluated. Adverse events (AEs) were followed up continuously for 15 months.

Results:
Of the 143 patients (mean age 62 ± 17 years; 54% males) included in the analysis, most (72%) were diagnosed with chronic neuropathic pain. The stable daily dose, after a mean 26 ± 10 days of titration was 1,500 ± 688 μg aerosolized Δ9-THC. Significant pain reduction, ranging from 22.8% in the intent-to-treat population to 28.4% in the population that reported baseline pain intensity ≥8 points on the NPS (P < 0.001), was observed. Ninety-two percent of patients reported improved QoL. Adverse events were reported mostly during the titration phase (34% of patients) and declined to ≤4% at 3 to 15 months. Only 7% of patients reported psychoactive AEs (anxiety and restlessness).

Conclusions:
Medical cannabis treatment with the Syqe Inhaler demonstrated overall long-term pain reduction, QoL improvement, and a superior AE profile compared with administration of MC by conventional routes. Additional follow-up in a larger population is warranted.