bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, Awareness and Perception of Antibiotics Resistance among under graduates Paramedical students of Bangladesh
Authors: Shah Ram Chandra , Pradhan Nabita , Yadav Rakesh Kumar 
Published: April 2022

Background and Objectives: Antibiotic resistance has become a global public health concern. Thus, the objectives of this study was to determine the overall knowledge of drugs and explore the level of awareness of antibiotic resistance among students studying at Jahangir-Nagar University, Bangladesh.
Material and Methods: The total period of sample collection was from June 2018 to October 2018 and the participants (was N=100). This descriptive cross-sectional study used a questionnaire that consisted of fifteen close ended questions and specific questions were on background (gender, age, education) characteristics. Descriptive statistics (frequency, distribution, mean and standard deviation was used to describe the data. The data collected from the 100 students nd analyzed by statistical tools (SPSS V.22) by drawing tables and graphs.
Results: Overall, 100 female students (age from 19 to 24 years) were interviewed and the response rate was 100%. Out of total respondents, around 86% of the sample stated that antibiotics are appropriate for bacterial infections and 34% of the students had agreed antibiotic can cure viral infections. 74% of the respondents hadn’t expected antibiotics when they had enough with cold, fever, cough and sore throat. Some had taken without prescription. Almost above 90% of the students stop taking those drugs when symptoms decrease and do not take full dose. About 91% respondent agreed to the need of more education about antibiotic resistance.
Conclusion: It is important to generate more awareness around this issue among all. It would be advisable to introduce a specific course and training on antibiotics in core curriculum of students.
Pelaksanaan Layanan Hak Tanggungan Terintegrasi Secara Elektronik
Authors: Margaret Agata Tri Putri , Sapardiyono Sapardiyono 
Published: April 2022

ABSTRACT
The HT-el service has been implemented nationally since April 2020, which in its implementation involves other parties such as Land Deed Maker Officials and Creditors as working partners. The purpose of this study is to describe the service mechanism, problems, and efforts to resolve the HT-el service with a location at the Land Office of Tanjung Jabung Barat Regency. This study uses a qualitative method with a descriptive approach to be able to see and understand the real conditions of the object under study. The results of the study found that the HT-el service mechanism had not been fully implemented in accordance with applicable regulations, for example, the existence of an HT-el certificate that was issued without going through an inspection process, accounts run by non-account owners, payment of deposit orders made by the bank (creditor). Problems faced by PPAT, Creditors and Kantah such as: internet network disturbances, the uploaded application file is not appropriate, ranking errors because the validation has not been completely correct, the online checking process cannot be carried out because all land parcel certificates have not been validated, NIK of the debtor or the approval party does not match, the deed code is not found in the HT-el system.
Keywords: Electronic Mortgage, PPAT, Bank

INTISARI
Layanan HT-el dilaksanakan secara nasional sejak bulan April 2020, yang dalam pelaksanaannya melibatkan pihak lain seperti Pejabat Pembuat Akta Tanah dan Kreditor sebagai mitra kerjanya. Tujuan penelitian ini adalah mendeskripsikan mekanisme layanan, permasalahan dan upaya penyelesaian terhadap layanan HT-el dengan lokasi di Kantor Pertanahan Kabupaten Tanjung Jabung Barat. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif agar dapat melihat dan memahami kondisi secara nyata terhadap objek yang diteliti. Hasil penelitian menemukan bahwa mekanisme layanan HT-el belum sepenuhnya dilakukan sesuai dengan ketentuan yang berlaku, misalnya adanya sertipikat HT-el yang terbit tanpa melalui proses pemeriksaan, akun yang dijalankan oleh bukan pemilik akun, pembayaran Surat Perintah Setor dilakukan oleh pihak Bank (Kreditor). Permasalahan yang dihadapi oleh PPAT, Kreditor dan Kantah seperti: gangguan jaringan internet, berkas permohonan yang diunggah belum sesuai, kesalahan peringkat karena validasi yang dilakukan belum sepenuhnya benar datanya, proses pengecekan secara online tidak dapat dilakukan karena belum tervalidasinya seluruh sertipikat bidang tanah, NIK dari Debitor ataupun pihak persetujuan tidak sesuai, Kode akta tidak ditemukan pada sistem HT-el.
Kata Kunci: Hak Tanggungan elektronik, PPAT, Kreditor
Evaluation of the dynamics of reconstruction of the act of swallowing in the postoperative period in patients with oncopathology of the oral cavity
Authors: Kushta A. A. 
Published: April 2022

Annotation. The article presents the results of the analysis of the data of ultrasound examination of the act of swallowing in patients with oncopathology of the oral cavity in the B- and M-mode in the pre- and postoperative period. The study included 26 patients aged 38-65 years, normotrophic patients who were treated in the Department of Head and Neck Tumors “Podolsk Regional Oncology Center” with malignant tumors of the tongue (group 1 – 12 patients with cancer of the lateral surface of the tongue, group 2 – 8 patients with cancer of the root of the tongue,) and the bottom of the mouth and oropharynx (3rd group – 6 patients). Scanning was performed in the sagittal and frontal planes with a 7.5 MHz sensor in two modes B and M at rest and during the act of swallowing in several stages on a TOSHIBA device (Model USDI-A500A/EL; Serial № ELA14Z2082). Data on several indicators were analyzed: chin-sublingual distance; longitudinal examination of the sublingual muscle group; transverse examination of the supralingual muscle group; examination in the lateral projection of the anterior abdomen of the biceps; determination of the amplitude of muscle contraction on the right and left, which makes it possible to compare their synchronicity and force of contraction. Statistical processing of the obtained data was performed using Excel software from Microsoft Office 2003, STATISTICA 5.5 (owned by CNIT National Pirogov Memorial Medical University, Vinnytsya, licensed № AXXR910A374605FA) according to the Student's test at p<0,05. The results of the study indicate that in patients with cancer of the lateral surface of the tongue on the 10th day resumed the act of swallowing. And in patients with cancer of the mucous membrane of the oral cavity and the root of the tongue for 12-14 days. The use of ultrasound examination of the act of swallowing in the dynamics is informative and provides objective indicators for the transfer of the patient from tube feeding to self.
Resepsi Satire Dunia Politik dalam Novel Sabdo Cinta Angon Kasih Karya Sujiwo Tejo
Authors: Theum Dita Chrysan , Wijaya Putra Candra Rahma 
Published: April 2022

Abstract
The reseach paper is entiltled “ Satire Problem Political Indication in Sujiwo Tejo’s Sabdo Cinta Angon Kasih Novel “.Social problems in the political worlda are increasimgly in the spotight in society. This study aims at this first, studying the relevance of the Sabdopalon puppet. Second, being able to understand Sujiwo Tejo’s reception of Sabdo Palon’s characterization. Third, showing how the form criticism for political elite the perspective of phenomenon that is being viral in the form of political problematic satire. This study data source is in the form of quote in the npvel Sabdo Cinta Angon Kasih by Sujiwo Tejo. Data collection techniques by reading in depth and giving a sign. The results of results of the study are in part the following , !) The story of the puppet show Sabdo Palon, 2) The reception of the figure of Sabdopalon in the novel Sujiwo Tejo’s, and 3) Social criticism in the form of satire in the novel Sabdo Cinta Angon Kasih.

Abstrak
Penelitian ini berjudul “ Satire Indikasi Problematika Dunia Politik Dalam Novel Sabdo Cinta Angon Kasih Karya Sujiwo Tejo” dunia politik menjadi sorotan dalam novel ini. Penelitian ini bertujuan untuk ini pertama, mempelajari relevansi pewayangan Sabdo palon. Kedua, mampu menjelaskan resepsi Sujiwo Tejo terhadap penokohan Sabdo Palon.. Ketiga, menunjukan bagaimana bentuk kritikan untuk kaum elit politik dalam prespektif fenomena yang sedang viral dalam bentuk satire problematika politik. Penelitian ini termasuk dalam penelitian deskritif kualitatif dengan menjabarkan hasil analisis berdasarkan teori. Teori yang digunakan ialah teori resepsi sastra melalui pendekatan sosiologi sastra Sumber data berupa kutipan dalam novel Sabdo Cinta Angon Kasih karya Sudjiwo Tejo. Teknik pengumpulan data dengan membaca secara mendalam dan memberikan tanda. Hasil penelitian adalah sebagian berikut 1) Kisah pewayangan Sabdopalon, 2) Resepsi Tokoh Sabdopalon dalam novel Sujiwo Tejo, 3) Kritik sosial berupa satire dalam novel Sabdo Cinta Angon Kasih terhadap problematika perpolitikan yang tengah viral di masyarakat.
PENGUATAN STRATEGI KEAMANAN MANUSIA DI PERBATASAN MOTA AIN (INDONESIA) DENGAN BATUGADE (TIMOR LESTE)
Authors: Anna Yulia Hartati  , Ali Martin  , Mario P. Rebelo Soares  
Published: April 2022

ABSTRAK

Pengelolaan perbatasan Indonesia –Timor Leste yang masih berorientasi pada keamanan teritorial mengindikasikan bahwa negara memandang keamanan perbatasan sebagai sebuah ancaman dari luar sehingga strategi penguatan state security terus dilakukan, di mana peran militer diperkuat untuk mengawal tapal batas. Padahal, persoalan penting yang sangat membutuhkan penanganan sesegera mungkin adalah masalah keamanan manusia seperti kebutuhan akan kecukupan pangan, bebas dari ancaman penyakit, kebodohan, pelanggaran HAM, dan lain sebagainya. Untuk itu, negara perlu memperkuat keamanan individu sebagai cara untuk mempertebal rasa identitas bangsa dan semangat nasionalisme yang akan berdampak pada kesadaran rakyat untuk menjaga keutuhan, keamanan dan kedaulatan negaranya. Artikel ini bertujuan untuk mendiskusikan pentingnya strategi penguatan human security di perbatasan Indonesia – Timor Leste sebagai cara untuk mewujudkan kepentingan nasional. Dengan menggunakan desain studi kasus dan pendekatan kualitatif, tulisan ini berupaya menjelaskan kondisi keamanan manusia di area perbatasan Mota Ain. Beberapa permasalahan seperti rendahnya tingkat kesejahteraan masyarakat menunjukkan buramnya potret keamanan individu di perbatasan kedua negara. Mendasari argumen ini, ada alternatif strategi yang bisa dilakukan pemerintah yaitu menerapkan strategi penguatan human security dalam pengelolaan perbatasan kedua negara. Jadi,komponen yang berperan dalam memelihara keamanan tidak hanya kaum militer, tetapi juga non militer.
Kata kunci: Perbatasan Indonesia-Timor Leste, Pengelolaan perbatasan, Human security.
Adult diffuse intrinsic pontine glioma: clinical, radiological, pathological, molecular features, and treatments of 96 patients
Authors: Wang Yi , Pan Changcun , Xie Mingguo , Zuo Pengcheng , Li Xiaoou , Gu Guocan , Li Tian , Jiang Zhuang , Wu Zhen , Zhang Junting , Zhang Liwei 
Published: April 2022

OBJECTIVE
Unlike its pediatric counterpart, adult diffuse intrinsic pontine glioma (DIPG) remains largely unelucidated. In this study, the authors examined the clinical, radiological, pathological, molecular, and clinical aspects of 96 adult DIPGs.

METHODS
The National Brain Tumor Registry of China (April 2013–December 2019) was used to collect data on radiologically diagnosed adult DIPG patients. Survival analysis was conducted using Kaplan-Meier curves and univariate and multivariate Cox regression. The chi-square test/Wilcoxon rank-sum test and multivariable logistic regression were used to examine the clinical and radiological characteristics of patients with long-term survival (LTS). Interaction analyses between clinical factors were also conducted.

RESULTS
The median age at symptom onset was 33.5 years, and the median duration of symptoms was 4.5 months. The frequencies of H3K27M and IDH1 mutations were 37.2% and 26.5%, respectively. All adult DIPG patients had a median overall survival (OS) of 19.5 months, with 1-, 2-, and 3-year survival rates of 67.0%, 42.8%, and 36.0%, respectively. The median OS of 40 patients who did not undergo treatment was 13.4 months. Patients with H3K27M-mutant tumors had a poorer prognosis than those with IDH-mutant tumors (p < 0.001) and H3K27M(−)/IDH–wild-type tumors (p = 0.002), with a median OS of 11.4 months. The median OSs of patients with H3K27M-mutant tumors who received treatment and those who did not were 13.8 months and 7.5 months, respectively (p = 0.016). Among patients with and without a pathological diagnosis, H3K27M mutation (p < 0.001) and contrast enhancement on MRI (p = 0.003), respectively, imparted a worse prognosis. Treatments were the predictive factor for patients with H3K27M-mutant tumors (p = 0.038), whereas contrast enhancement on MRI was the prognostic factor for the H3K27M(−) group (p = 0.038). In addition, H3K27M mutation and treatment were significant predictors for patients with symptom duration ≤ 4 months (H3K27M, p = 0.020; treatment, p = 0.014) and tumors with no contrast enhancement (H3K27M, p = 0.003; treatment, p = 0.042). Patients with LTS were less likely to have cranial nerve palsy (p = 0.002) and contrast enhancement on MRI at diagnosis (p = 0.022).

CONCLUSIONS
It is recommended that all adult DIPG patients undergo genomic testing for H3K27M and IDH mutations. Despite the low prevalence, additional study is needed to better characterize the efficacy of various treatment modalities in adults with DIPG.
Association between socioeconomic status and presenting characteristics and extent of disease in patients with surgically resected nonfunctioning pituitary adenoma
Authors: Cote David J. , Ruzevick Jacob J. , Kang Keiko M. , Pangal Dhiraj J. , Bove Ilaria , Carmichael John D. , Shiroishi Mark S. , Strickland Ben A. , Zada Gabriel 
Published: April 2022

OBJECTIVE
The aim of this study was to evaluate the association between zip code–level socioeconomic status (SES) and presenting characteristics and short-term clinical outcomes in patients with nonfunctioning pituitary adenoma (NFPA).

METHODS
A retrospective review of prospectively collected data from the University of Southern California Pituitary Center was conducted to identify all patients undergoing surgery for pituitary adenoma (PA) from 2000 to 2021 and included all patients with NFPA with recorded zip codes at the time of surgery. A normalized socioeconomic metric by zip code was then constructed using data from the American Community Survey estimates, which was categorized into tertiles. Multiple imputation was used for missing data, and multivariable linear and logistic regression models were constructed to estimate mean differences and multivariable-adjusted odds ratios for the association between zip code–level SES and presenting characteristics and outcomes.

RESULTS
A total of 637 patients were included in the overall analysis. Compared with patients in the lowest SES tertile, those in the highest tertile were more likely to be treated at a private (rather than safety net) hospital, and were less likely to present with headache, vision loss, and apoplexy. After multivariable adjustment for age, sex, and prior surgery, SES in the highest compared with lowest tertile was inversely associated with tumor size at diagnosis (−4.9 mm, 95% CI −7.2 to −2.6 mm, p < 0.001) and was positively associated with incidental diagnosis (multivariable-adjusted OR 1.72, 95% CI 1.02–2.91). Adjustment for hospital (private vs safety net) attenuated the observed associations, but disparities by SES remained statistically significant for tumor size. Despite substantial differences at presentation, there were no significant differences in length of stay or odds of an uncomplicated procedure by zip code–level SES. Patients from lower-SES zip codes were more likely to require postoperative steroid replacement and less likely to achieve gross-total resection.

CONCLUSIONS
In this series, lower zip code–level SES was associated with more severe disease at the time of diagnosis for NFPA patients, including larger tumor size and lower rates of incidental diagnosis. Despite these differences at presentation, no significant differences were observed in short-term postoperative complications, although patients with higher zip code–level SES had higher rates of gross-total resection.
Assessing the differences in operative and patient-reported outcomes between lateral approaches for lumbar fusion: a systematic review and indirect meta-analysis
Authors: Bhatti Atiq ur Rehman , Cesare Joseph , Wahood Waseem , Alvi Mohammed Ali , Onyedimma Chiduziem E. , Ghaith Abdul Karim , Akinnusotu Oluwatoyin , El Sammak Sally , Freedman Brett A. , Sebastian Arjun S. , Bydon Mohamad 
Published: April 2022

OBJECTIVE
Anterior-to-psoas lumbar interbody fusion (ATP-LIF), more commonly referred to as oblique lateral interbody fusion, and lateral transpsoas lumbar interbody fusion (LTP-LIF), also known as extreme lateral interbody fusion, are the two commonly used lateral approaches for performing a lumbar fusion procedure. These approaches help overcome some of the technical challenges associated with traditional approaches for lumbar fusion. In this systematic review and indirect meta-analysis, the authors compared operative and patient-reported outcomes between these two select approaches using available studies.

METHODS
Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) approach, the authors conducted an electronic search using the PubMed, EMBASE, and Scopus databases for studies published before May 1, 2019. Indirect meta-analysis was conducted on fusion rate, cage movement (subsidence plus migration), permanent deficits, and transient deficits; results were depicted as forest plots of proportions (effect size [ES]).

RESULTS
A total of 63 studies were included in this review after applying the exclusion criteria, of which 26 studies investigated the outcomes of ATP-LIF, while 37 studied the outcomes of LTP-LIF. The average fusion rate was found to be similar between the two groups (ES 0.97, 95% CI 0.84–1.00 vs ES 0.94, 95% CI 0.91–0.97; p = 0.561). The mean incidence of cage movement was significantly higher in the ATP-LIF group compared with the LTP-LIF group (stand-alone: ES 0.15, 95% CI 0.06–0.27 vs ES 0.09, 95% CI 0.04–0.16 [p = 0.317]; combined: ES 0.18, 95% CI 0.07–0.32 vs ES 0.02, 95% CI 0.00–0.05 [p = 0.002]). The mean incidence of reoperations was significantly higher in patients undergoing ATP-LIF than in those undergoing LTP-LIF (ES 0.02, 95% CI 0.01–0.03 vs ES 0.04, 95% CI 0.02–0.07; p = 0.012). The mean incidence of permanent deficits was similar between the two groups (stand-alone: ES 0.03, 95% CI 0.01–0.06 vs ES 0.05, 95% CI 0.01–0.12 [p = 0.204]; combined: ES 0.03, 95% CI 0.01–0.06 vs ES 0.03, 95% CI 0.00–0.08 [p = 0.595]). The postoperative changes in visual analog scale (VAS) and Oswestry Disability Index (ODI) scores were both found to be higher for ATP-LIF relative to LTP-LIF (VAS: weighted average 4.11 [SD 2.03] vs weighted average 3.75 [SD 1.94] [p = 0.004]; ODI: weighted average 28.3 [SD 5.33] vs weighted average 24.3 [SD 4.94] [p < 0.001]).

CONCLUSIONS
These analyses indicate that while both approaches are associated with similar fusion rates, ATP-LIF may be related to higher odds of cage movement and reoperations as compared with LTP-LIF. Furthermore, there is no difference in rates of permanent deficits between the two procedures.
Comparison of anterior cervical discectomy and fusion versus artificial disc replacement for cervical spondylotic myelopathy: a meta-analysis
Authors: Chang Chao-Jui , Liu Yuan-Fu , Hsiao Yu-Meng , Huang Yi-Hung , Liu Keng-Chang , Lin Ruey-Mo , Lin Cheng-Li 
Published: April 2022

OBJECTIVE
Anterior cervical discectomy and fusion (ACDF) has long been regarded as a gold standard in the treatment of cervical myelopathy. Subsequently, cervical artificial disc replacement (c-ADR) was developed and provides the advantage of motion preservation at the level of the intervertebral disc surgical site, which may also reduce stress at adjacent levels. The goal of this study was to compare clinical and functional outcomes in patients undergoing ACDF with those in patients undergoing c-ADR for cervical spondylotic myelopathy (CSM).

METHODS
A systematic literature review and meta-analysis were performed using the Embase, PubMed, and Cochrane Central Register of Controlled Trials databases from database inception to November 21, 2021. The authors compared Neck Disability Index (NDI), SF-36, and Japanese Orthopaedic Association (JOA) scores; complication rates; and reoperation rates for these two surgical procedures in CSM patients. The Mantel-Haenszel method and variance-weighted means were used to analyze outcomes after identifying articles that met study inclusion criteria.

RESULTS
More surgical time was consumed in the c-ADR surgery (p = 0.04). Shorter hospital stays were noted in patients who had undergone c-ADR (p = 0.04). Patients who had undergone c-ADR tended to have better NDI scores (p = 0.02) and SF-36 scores (p = 0.001). Comparable outcomes in terms of JOA scores (p = 0.24) and neurological success rate (p = 0.12) were noted after the surgery. There was no significant between-group difference in the overall complication rates (c-ADR: 18% vs ACDF: 25%, p = 0.17). However, patients in the ACDF group had a higher reoperation rate than patients in the c-ADR group (4.6% vs 1.5%, p = 0.02).

CONCLUSIONS
At the midterm follow-up after treatment of CSM, better functional outcomes as reflected by NDI and SF-36 scores were noted in the c-ADR group than those in the ACDF group. c-ADR had the advantage of retaining range of motion at the level of the intervertebral disc surgical site without causing more complications. A large sample size with long-term follow-up studies may be required to confirm these findings in the future.