bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational approach to examine Interactivity between locomotion of bacteria and FENE-P slime adhere to slippery surface
Authors: Asghar Zeeshan , Shah Rehman Ali , Ali Nasir 
Published: July 2022

Abstract
Motility is a fundamental attribute of bacteria and is one of the common traits shown by it. Many bacteria swim freely in a fluid via rotation of flagella filament, while on the other hand many of them have developed a several varieties of cell motility mechanism without the aid of flagella. The later type of motility mechanism is adopted by rod-shaped bacteria known as gliding bacteria. These gliding bacteria can secrete an extracellular polymeric substance that allow them to move without flagella. This mysterious motility of gliding bacteria has been very attractive to many researchers in recent years and have been studied theoretically/experimentally and mathematically. In the current analysis, a mathematical fluid model (FENE-P) is used to explicate the motility of gliding bacteria on slippery, soft and rigid surfaces. For the mathematical description of the governing equations Cartesian coordinates are used. By utilizing the dimensionless variables, long wavelength and small Reynolds number approximation, the modeled partial differential equation are reduced into forth-order differential equation. The resultant highly non-linear ODEs for the large values of emerging parameters are numerically solved by Newton-Raphson technique. The study revel that the emerging parameters have major effects on gliding speed of the cell, flow rate of the slime and power consumed by the cell. The salient physical application of governing parameters is graphically underlined for soft and rigid surfaces. The outcomes are elaborated in detail further, it is renowned that the current analysis has many biomechanical applications such as it is relevant to marine anti-bacteria fouling and biofuel cell technologies.
Biliary granulomatous peritoneal reaction as consequence of cholecystectomy: a case report and a revision of the literature.
Authors: Tarantino Giuseppe , Menghini Denise , Argenziano Maria Eva , Palmieri Miriam , Mandolesi Alessandra , Bona Enrico Dalla , Benedetti Antonio , Guerrieri Mario , Danieli Maria Giovanna 
Published: July 2022

Abstract
Introduction: Bile or gallstone spillage during laparoscopic cholecystectomy occurs in 13 to 40% of cases of surgical dissection and extraction of very inflamed gallbladder with friable or gangrenous walls. Case presentation: We present a case of a patient who developed this rare complication after a difficult cholecystectomy for acute-on-chronic cholecystitis. Our patient, after about 2 years from the surgery, in the follow-up imaging studies, showed multiple nodules disseminated in the peritoneal cavity suggestive for malignancy both on abdomen computer tomography scan and on positron emission tomography. Thus, laparoscopic nodulectomy, lastly allowed histologic diagnosis of biliary peritoneal granulomatous reaction. Even if benign assessment of nodules’ nature, these lesions showed a progressive trend in increasing over the time in number and dimensions. We performed PubMed research of all cases reported in literature, to examine the cases features and to compare our findings with other clinical experiences reported by eleven international canters. Many patients were completely asymptomatic; as an occasional finding mimicking peritoneal seeding, further assessment to define the benign nature of these nodules were performed, so they underwent surgical treatment.In conclusion, development of multiple abdominal nodules resulting from a foreign-body granulomatous reaction to bile/gallstones is a quite rare event after laparoscopic cholecystectomy, but we believe it should be seriously considered in patients undergone complicated surgical procedures on biliary tracts.
Robot-Assisted Radical Prostatectomy: Accessory Pudendal Arteries Preservation and Effects on Sexual Functions
Authors: Arikan Yusuf , Seker Kamil Gokhan , Yenice Mustafa Gurkan , Kargi Taner , Tugcu Volkan 
Published: July 2022

Abstract
Background: Aim of this study was to show the importance of accessory pudendal arteries (APAs) on erectile function in patients who underwent robot-assisted radical prostatectomy (RALP).Methods: We retrospectively reviewed data of 988 RALP procedures performed in our institution between 2010 and 2018. 55 patients who were APA (+) and 76 patients who were APA (-) and underwent RALP procedures were included in the study. Demographic characteristics, preoperative clinical information, peroperative data and pathologic data were collected. IIEF-5 scores preoperatively and postoperative 3rd, 6th, 12th and 18th months, registered.Results: The mean age, in the study group was 61 ± 6.2 yeas. Mean BMI was 27.2 ± 1.8 kg/m2. The mean surgical duration was 161.9±24.7 minutes and the mean blood loss was 134.4±95.9 ml. Surgical time (170 min vs 150 min) and per-op blood loss (120 mL vs 100 mL) were significantly higher in the APA (+) group compared with APA (-) group (p < 0.05). There was no significant (p>0.05) difference in the preop IIEF-5 scores in APA (-) and APA (+) groups but IIEF-5 scores in postop 3rd, 6th, 12th and 18th months were significantly higher (p<0.05) in the APA(+) group compared to APA(-) group. No significant decrease was detected in IIEF-5 scorse in the postop follow-ups in either group (p<0.05).Conclusions: In this study, we showed that APA presence is an important factor in the preservation of sexual function and if APAs are detected, preservation of this arterial structure should be among the steps of RALP.
Alcohol-induced C/EBP β-driven KIAA1429 decreases oxidative stress and promotes pancreatic cancer growth and metastasis via the m6A/YTHDF2/SLC43A2 pathway
Authors: Wang Gang , Gao Lei , Lv Gaoyuan , Liu Ziying , Tang Desheng , Yan Changsheng , Ma Jiamin , Cheng Long , Li Le , Sun Bei , Tang Qiushi 
Published: July 2022

Abstract
N6-methyladenosine (m6A) is implicated in tumorigenesis. To data, the role of KIAA1429, an RNA methyltransferase in pancreatic cancer (PC) has not been clearly defined. The present study demonstrated that KIAA1429 was upregulated in PC. Overexpression of KIAA1429 accelerated PC proliferation and metastasis, whereas knockdown of KIAA1429 had an opposite effect. Mechanistically, KIAA1429 promoted the degradation of SLC43A2 mRNA via an m6A-YTHDF2 mechanism, and downregulation of SLC43A2 reduced phenylalanine absorption and oxidative stress, thus enhancing the progression of PC. In addition, alcohol induced the expression of C/EBP β, which bound to the promoter of KIAA1429 and boosted its transcription. The findings of the present study revealed a potential link between alcohol consumption, m6A and phenylalanine absorption in PC progression, providing a novel means to combat this disease.
Nanobodies Targeting ABCC3 for Immunotargeted Applications in Glioblastoma
Authors: Ruiz-López Eduardo , Jovčevska Ivana , González-Gómez Ruth , Tejero Héctor , Al-Shahrour Fátima , Muyldermans Serge , Schuhmacher Alberto J. 
Published: July 2022

Abstract
The cancer “omics” reveal many clinically relevant alterations that are transforming the molecular characterization of glioblastomas. However, many of these findings are not yet translated into clinical practice due, in part, to the lack of non-invasive biomarkers and the limitations imposed by the blood-brain barrier. Nanobodies, camelid single-domain antibody fragments, emerge as a promising tool for immunotargeted applications for diagnosing and treating glioblastomas. Performing agnostic bioinformatic analysis from glioblastoma patient datasets, we identified ATP Binding Cassette subfamily C member 3 (ABCC3) as a suitable target for immunotargeted applications. The expression of ABCC3 is associated with poor survival and impaired response to temozolomide. Importantly, high expression of ABCC3 is restricted to glioblastoma, with negligible levels in healthy brain tissue, and further correlates with tumor grade and stemness markers. We identified three immunogenic epitopes of ABCC3 which were used to isolate nanobodies from a glioblastoma-specific phage-display nanobody library. Two nanobodies targeting ABCC3 (NbA42 and NbA213) were further characterized and demonstrated in vivo selective recognition of ABCC3 in glioblastoma xenograft models upon systemic administration. We designate NbA42 and NbA213 as new candidates to implement immunotargeted applications guiding a more personalized and precise diagnosis, monitoring, and treatment of glioblastoma patients.
Magnetic Seed versus skin tattoo localization of non-palpable breast lesions: a single institution cohort study
Authors: D'Angelo Anna , Scardina Lorenzo , Palma Simone , Cicero Stefano Lo , Maresca Alessandro , Biondi Ersilia , Franco Antonio , Terribile Daniela , Franceschini Gianluca , Belli Paolo , Manfredi Riccardo 
Published: July 2022

Abstract
Background: The increasing number of diagnosis of non-palpable breast cancers has led to a need of constant improvement of imaging techniques preoperative localization. The current scenario counts different techniques, including: wire localization, radio-guided occult localization (ROLL), non-radioactive radar localization and skin tattoo. The choice of which one to use depends on surgeon’s and radiologist’s different skills. The introduction of magnetic seed localization technique facilitates the theater scheduling in the absence of same day radiology presence. Objective: The objective of this restrospective study was to investigated the accuracy and feasibility of Magseed compared to skin tattoo in the preoperative localization of impalpable breast lesions in terms of accuracy of placement, re-excision and positive margin rates and breast/surgical specimen volume ratio.Methods: From November 2020 to November 2021 we retrospectively analysed 77 patients. Results: 37 magnetic seeds were placed in 36 patients (48.6%) and 40 skin tattoos were performed in the remained cases (51.4%). With both methods, 100% of the index lesions were completely removed and found in the surgical specimen. The re-excision rate reported was 0% for both groups. Magseed was used with greater frequency in patients with small lesions (p=0.017) and medium breasts (B cup 62.2%). A significant difference was also observed in the breast parenchyma removed between Magseed group and skin tattoo (p=0.003), especially in case of small lesions. Conclusions: Magseed placement is a save, nonradioactive localization technique, that improves scheduling efficiency, recommended in case of impalpable, smaller lesions and medium-large breasts.
Building communities of practice through case-based e-learning to prevent and manage TB among people living with HIV–India
Authors: Agarwal Reshu , Agarwal Upasna , Das Chinmoyee , Allam Ramesh Reddy , Pant Rashmi , Ho Christine , Kumar B Ravi , Dabla Vandana , Moonan Patrick K , Nyendak Melissa , Anand Sunil , Puri Anoop Kumar , Mattoo Sanjay Kumar , Sachdeva Kuldeep Singh , Yeldandi Vijay V , Sarin Rohit 
Published: July 2022

Abstract
Background: Addressing TB among people living with HIV (PLHIV) is a key priority for the Government of India (GoI). In 2016, GoI implemented single-window services to prevent and manage TB in PLHIV. To strengthen HIV-TB service delivery, case-based e-learning was introduced to health care providers at ART centres (ARTc). Methods: We implemented a hub and spoke model to deliver biweekly, virtual, case-based e-learning at select ARTc (n=115), from four states of India-–Delhi, Uttar Pradesh, Andhra Pradesh and Tamil Nadu. We evaluated feasibility and acceptability of case-based e-learning and its impact on professional satisfaction, self-efficacy, knowledge retention using baseline and completion surveys, session feedback, pre-and post-session assessments. We reviewed routine programmatic data and patient outcomes to assess practices among participating ARTc. Results: Between May 2018–September 2020, 59 sessions were conducted with mean participation of 55 spokes and 152 participants. For 95% and 88% of sessions≥80% of respondents agreed that topics were clear and relevant to practice, and duration of session was appropriate, respectively. Session participants significantly improved in perceived knowledge, skills and competencies (+8.6%;p=0.025), and technical knowledge (+18.3%;p=0.04) from baseline. Participating ARTc increased TB screening (+4.2%,p<0.0001)), TB diagnosis(+2.7%,p<0.0001), ART initiation(+4.3%,p<0.0001) and TB preventive treatment completion (+5.2%,p<0.0001).Conclusion: Case-based e-learning is an acceptable and effective modus of capacity building and developing communities of practice to strengthen integrated care. E-learning could address demand for accessible and sustainable continuing professional education to manage complex diseases, particularly co-morbidities and thereby enhance health equity.
Experimental investigation and theoretical prediction of forming limit diagram of DP600 steel sheets
Authors: Zheng Qiuli , Yan Jiaming , Li Jieqing , Xu Xiaodong , Liu Haoyang , An Xiujuan 
Published: July 2022

Abstract
Dual phase steels are the ideal substitutes for conventional steels to reduce the weight of vehicles and decrease fuel consumption, and their mechanical properties have attracted much attention. Therefore, this work established strain-based forming limit diagrams (FLDs) for DP600 steel sheets by means of experimental investigation and theoretical prediction. To obtain the analytical limit strains in the biaxial and uniaxial tensile case, the Swift’s diffuse instability model and Hill’s localized instability model were adopted, respectively. The results showed that compared with the theoretical forming limit curve (FLC) predicted by Keeler equation, the theoretical FLCs predicted by the Hill'79 yield criterion or the Logan-Hosford yield criterion were more suitable for predicting the forming limit of DP600 steel sheets. The experimental results showed that the limit major strain of DP600 material is 41% under uniaxial tensile strain path, 43% under biaxial tensile strain path and 18% under plane strain path. Solutions from the analytical methods were compared with experimental FLD established based on combining uniaxial tensile tests and hydraulic bulging tests, only with an error of 3%, proving the rationality and accuracy of the theoretical prediction.
Device Association and Trajectory Planning for UAV-Assisted MEC in IoT: A Matching Theory Based Approach
Authors: Zhang Xinjun , Zhang Guopeng , Wang Kezhi , Yang Kun 
Published: July 2022

Abstract
Unmanned aircraft vehicle (UAV) -assisted mobile edge computing (MEC) is an effective way to alleviate the lack of energy and computing power of the Internet of Things (IoT) devices in remote areas. This paper considers the competition among multiple aerial service providers (ASPs) to provide UAV-assisted MEC services to multiple ground network operators (GNOs). We first quantify the conflicting interests of the ASPs and GNOs by different profit functions. Then, the system-wide UAV scheduling and resource allocation is formulated as a multi-objective optimization problem, where an ASP aims to reap the most profits from providing MEC services to the GNOs, while a GNO aims to seek the service of a certain ASP to meet its performance requirements. This problem is a mixed-integer nonlinear programming (MINLP), and we propose a matching theory based algorithm to solve it. We first investigate the UAV trajectory planning and resource allocation between a single UAV and a single service area, and solve it using the Lagrange relaxation and successive convex optimization (SCA) methods. According to the obtained results, the GNOs and ASPs are associated in the framework of the matching theory, which results in a weak Pareto optimality. Simulation results show that the proposed matching theory based algorithms achieve the considerable performance.
The Impacts of a Middle-School Art-based Program on Academic Achievements, Creativity, and Creative Behaviors
Authors: Egana-delSol Pablo 
Published: July 2022

Abstract
This article conducts an impact evaluation of an art-based program, implemented in public schools, on academic achievements, creativity, and socioemotional skills and behaviors. The main contribution with respect to previous literature is a quasi-experimental design that makes the causal link between these aspects more plausible. Four main findings are derived from the empirical investigation. First, participation in at least two semester-length workshops is a necessary condition to observe significant impacts. Second, participation has a significant impact on academic achievements. Grades increased by 0.61 standard deviations (sd) for language, by 0.36 sd for math, and by 0.33 sd for art. Overall GPA increased by 0.55 sd. The art-based program also increased participant willingness to consider postsecondary education. Third, the impact of the art-based program on various innovative graphical psychometric measures of creativity was positive and significant. Fourth, related to creative behaviors, the art-based program had a positive impact on certain cultural activities, such as time spent watching films at home and creating cultural goods (e.g., handicrafts, poetry, music).
Recurrent Respiratory Papillomatosis (RRP) – Meta-analyses on the use of the HPV vaccine as adjuvant therapy.
Authors: Goon Peter , Sauzet Odile , Schuermann Matthias , Oppel Felix , Shao SenYao , Scholtz Lars-Uwe , Sudhoff Holger , Goerner Martin 
Published: July 2022

Abstract
Objectives and importance:Recurrent Respiratory Papillomatosis(RRP) is a rare disease with severe morbidity. Treatment is surgical. Prevailing viewpoint is that prophylactic HPV vaccines do not have therapeutic benefit due to their modus operandi. Studies on HPV vaccination alongside surgery were meta-analysed to test effect on burden of disease.MethodsDatabases accessed Nov & Dec 2021[PubMed, Cochrane, Embase & Web of Science]. Main outcome measured: Mean paired differences in the number of surgeries or recurrences per month. Analyses: Random effect maximal likelihood estimation model using the Stata module Mataan(StataCorp. 2019. Stata Statistical Software: Release 16. College Station, TX:StataCorp LLC.)Resultsn=38 patients, suitable for syntheses with one previous meta-analyses(4 published, 2 unpublished studies)n=63, total of n=101 patients. Overall mean reduction of ≥8 recurrences compared to similar pre-vaccination period (95% CI [3.84, 10.98]) over 5 years. ConclusionsMeta-analyses favours HPV vaccine as adjunct therapy alongside surgery Trial registration: PROSPERO (awaiting number)
pH-responsive Cellulose Nanomaterial Films Containing Anthocyanins for Intelligent and Active Food Packaging Applications
Authors: Shayan Mohammad , Gwon Jaegyoung , Koo Meen S , Lee Danbee , Adhikari Achyut , Wu Qinglin 
Published: July 2022

Abstract
A combination of cellulose nanocrystals (CNCs) and nano-fibrillated cellulose (NFC) was used as a sustainable substrate to immobilize anthocyanins in red cabbage extract (RCE) and prepare a pH-sensitive packaging film. The incorporation of RCE in the CNC/NFC suspension changed the morphology and increased the steady-state viscosity and storage modulus of the suspension. Three rheological models (i.e., Power-law, Herschel-Bulkley, and Nasiri-Ashrafizadeh) fitted the relationship between shear stress and shear rate for each suspension. The incorporation of RCE to the CNC/NFC suspension altered the physical, optical, and mechanical properties of the films and acted as a free radical scavenger. The incorporation of 50 wt.% RCE in the CNC/NFC film enhanced its elongation at break by around 855%. With the enhanced film flexibility, its tensile strength, however, declined. The developed indicator film contained 30 wt.% RCE demonstrated an optimum physical, mechanical, and optical properties with the lowest response time to alkaline pH, which has a great potential as a pH-sensitive film for use in the seafood packaging industry.
A Lymph Node Targeted Adjuvant and Engineered Subunit Vaccine Promotes Potent Immunity to Epstein-Barr Virus in HLA-expressing Mice
Authors: Dasari Vijayendra , McNeil Lisa , Beckett Kirrilee , Solomon Matthew , Ambalathingal George , Steinbuck Martin , Jakubowski Aniela , Seenappa Lochana , Palmer Erica , Zhang Jeff , Haqq Chris , DeMuth Peter , Khanna Rajiv 
Published: July 2022

Abstract
Recent emergence of a causal like between Epstein-Barr virus (EBV) and multiple sclerosis has generated considerable interest in the development of an effective vaccine against EBV. Here we describe a novel vaccine formulation based on a lymph node targeting Amphiphile (AMP) vaccine adjuvant, AMP-CpG, admixed with EBV gp350 glycoprotein and a novel EBV-polyepitope protein (EBVpoly) that includes 20 CD8+ T-cell epitopes from EBV latent and lytic antigens. Potent gp350-specific IgG responses were induced in mice with titers > 100,000 in AMP-CpG vaccinated mice. Immunization including AMP-CpG also induced high frequencies of polyfunctional gp350-specific CD4+ T-cells and EBVpoly-specific CD8+ T-cells that were 2-fold greater than soluble CpG and were maintained for > 7 months post immunization. This combination of broad humoral and cellular immunity against multiple viral determinants is likely to provide better protection against primary infection and control of latently infected B cells leading to protection against the development of EBV-associated diseases. Teaser: A lymph node targeted AMP-CpG subunit EBV vaccine induces potent and durable immunity in HLA expressing mice.
Robinson annulation methodsynthesis of (3-Benzoyl-4-hydroxy-4,6-diphenyl- 2-styryl-cyclohexyl)-phenyl-methanone:Antioxidant and Antibacterial studies
Authors: Suriyakala Tevaraj , Senthilkumar Velmurugan , Mohanraj Arumugam , Ravindran Gurusamy 
Published: July 2022

Abstract
The Robinson annulation represents a tandem process including the Michael addition and intramolecular Aldol condensation, affording (3-Benzoyl-4-hydroxy-4,6-diphenyl-2-styryl-cyclohexyl)-phenyl-methanone skeleton with symmetrical 1,5-Diketones and 1,5-Diphenyl-penta-2,4-dien-1-one being substrates.The reaction proceeds in NaOEt as a catalyst, with no by-product formation, and involves simple operation requiring, no column chromatography. Thus, this protocol fulfils all of the criteria that define green chemistry. All the new compounds have been characterized by 1HNMR and 13CNMR spectral analysis. The synthesised compounds were tested to antioxidant and antibacterialproperties.