bluuebunny/crossref_metadata_2025_split huggingface dataset:
Difficulties in retrieving specific details of autobiographical memories and imagining positive future events in individuals with acute but not remitted anorexia nervosa
Authors: Keeler Johanna Louise , Peters-Gill Georgia , Treasure Janet , Himmerich Hubertus , Tchanturia Kate , Cardi Valentina 
Published: November 2022

Abstract
Introduction
The factors that contribute to the maintenance of anorexia nervosa (AN) are not fully understood, although it is generally accepted that depression is a core feature and contributes to poor prognosis. Individuals with depression tend to have difficulties in producing specific details of autobiographical memories and future episodes. Our aim was to investigate autobiographical memory and episodic future thinking (EFT) in individuals with AN (n = 46), people recovered from AN (recAN; n = 40), and non-affected controls (n = 35).

Method
Using a remotely administered computerised version of the autobiographical memory test and episodic future thinking task, we measured six aspects of memory retrieval and EFT generation: specificity, detailedness, difficulty in remembering/imagining, positivity, vividness and realism. Memory and EFT cue valence was manipulated; cues were either positive, neutral, or disorder-related/negative. As the production of EFTs is theoretically linked to the ability to retrieve autobiographical memories, the relationship between autobiographical memory specificity and EFT specificity was explored. To investigate whether autobiographical memory and EFT performance were independent of performance on other forms of cognition, working memory, verbal fluency and cognitive flexibility were measured.

Results
People with AN had difficulties retrieving specific details of autobiographical memories and rated autobiographical memories as less positive overall, and less vivid when primed by positive cues. People with a lifetime diagnosis (currently ill or recovered) reported greater difficulty in retrieving memories. The AN group generated less positive EFTs, particularly to positive and neutral cues. Comorbid depressive symptoms had some contribution to the observed findings. Lastly, in all groups autobiographical memory specificity predicted EFT specificity.

Discussion
Problems with retrieving specific details of autobiographical memories and simulating positive EFTs may be a state feature of AN. Treatments targeted at alleviating depressive symptoms, as well those targeted towards facilitating memory retrieval or reconsolidation, and the construction of positive EFTs, may contribute to hope for recovery and strengthen the sense of self beyond the disorder.
Evaluation of the thermal performance of traditional courtyard houses in a warm humid climate: Colima, Mexico
Authors: Toris-Guitron M. Gabriela , Esparza-López Carlos J. , Luna-León Aníbal , Pozo Carlos Escobar-del 
Published: November 2022

Abstract
With the recent need to decrease energy use and promote indoor thermal comfort in overheating conditions, attention has been drawn to the passive cooling function of courtyards. This paper aims to determine the effect of proportions and orientations of courtyards on the indoor thermal performance of traditional houses in a warm, humid region so that this could guide further improvement and reinterpretation of this building type. The results of this parametric study were obtained through computer simulations of different cases with the aim to determine the influence of orientation, courtyard size and proportions on the indoor thermal energy balance and thermal comfort of a traditional building in a warm-humid region. Rather than promote passive cooling in the building, the findings suggest that the courtyard greatly increases solar heat gain, raising the temperature during the day. Higher solar heat gains and ventilation rates were observed in the courtyard cases with greater width and length. Nevertheless, this does not cause important differences in the average operative temperature of the entire building between the cases. As for orientation, lower heat gains were obtained in courtyards with the long axis-oriented east to west. Regardless of the cases, the study finally emphasizes the importance of the inhabitants controlling the opening of windows in the enclosed rooms since this could decrease the temperature by 1.1 °C from night to the early morning (23.00 hrs to 11.00hrs) and thus influence its thermal comfort. Conversely, opening the windows outside that time-lapse could cause an increase in temperature and more hours above the upper comfort limit.
How can artificial intelligence optimize value-based contracting?
Authors: Poveda Jose Luis , Bretón-Romero Rosa , Del Rio-Bermudez Carlos , Taberna Miren , Medrano Ignacio H. 
Published: November 2022

AbstractEfforts in the pharmaceutical market have been aimed at ensuring that the benefits obtained from the introduction of new therapies justify the associated costs. In recent years, drug payment models in healthcare have undergone a dramatic shift from focusing on volume (i.e., size of the target clinical population) to focusing on value (i.e., drug performance in real-world settings). In this context, value-based contracts (VBCs) were designed to align the payment of a drug to its clinical performance outside clinical trials by evaluating the effectiveness using real-word evidence (RWE). Despite their widespread implementation, different factors jeopardize the application of VBCs to most marketed drugs in a near future, including the need for easily measurable and relevant outcomes associated with clinical improvements, and access to a large patient population to assess said outcomes. Here, we argue that the extraction and analysis of massive amounts of RWE captured in patients’ electronic health records (EHRs) will circumvent these issues and optimize negotiations in VBCs. Particularly, the use of Natural Language Processing (NLP) has proven successful in the analysis of structured and unstructured clinical information in EHRs in multicenter research studies. Thus, the application of NLP to analyze patient-centered information in EHRs in the context of innovative contracting can be utterly beneficial as it enables the real-time evaluation of treatment response and financial impact in real-world settings.
Morphological and morphometric studies on the axial skeleton of the sitatunga (Tragelaphus spekii gratus)
Authors: Onwuama Kenechukwu Tobechukwu , Ibe Chikera Samuel , Jaji Alhaji Zubair , Salami Suleiman Olawoye , Kigir Esther Solomon 
Published: November 2022

Abstract
Background
Anatomical features of the skeleton of wild animals contribute largely to their adaptation. A dearth of information on the skeletal anatomy of the sitatunga (Tragelaphus spekii gratus) necessitated this study. Two adult sitatunga carcasses weighing 54 kg and 57 kg were obtained after post-mortem examination. Bone preparation was achieved through cold water maceration protocol.

Result
The tympanic bulla was elongated and massive, resulting in the rudimentary appearance of the styloid and muscular processes of the temporal bone. The lacrimal bone had a somewhat triangular presentation with the lacrimal foramen on the caudal border of the facial surface while its dorsal border formed the lateral margin of the frontal sinus. There was no observable lacrimal fossa on this facial surface of the lacrimal bone. The facial tubercle was absent. The vertebral column formula was C7 T13 L6 S4 C10-14, and the atlas dorsal median tubercle was smooth, devoid of ridges. The spinous process of the axis extended the entire arch length to hang little above the odontoid process. The thoracic spinous processes were oriented dorso-caudally from T1 to T11; spinous process of T12 was vertical, while that of T13 was oriented dorso-cranially. The length of the transverse process of L1 and L6 were the same, and smaller than the length of those of L2-L5. There was incomplete fusion of sacral spinous processes. Three dorsal and ventral sacral foramina were identified laterally on each side of the vertebrae. The ribs were 26 in number (13 pairs). The sternum was comprised of 5 sternabrae separated by intersternal cartilage. The average number of bones of the axial skeleton was 75. Morphometric in formation included the length of skull, mandible and ribs; body length of vertebrae and spinous process length and height of the vertebrae.

Conclusion
This study recorded anatomical features and biometric information on axial skeletal bones of the Sitatunga (Tragelaphus spekii gratus) thereby providing baseline data for future biomedical, archaeological and comparative skeletal anatomical studies.
Surgical management of bony orbit tumors
Authors: El-Sawy Medhat M. , Moawad Ahmed M. 
Published: November 2022

Abstract
Background
A variety of primary tumors affect the bony orbit. They include, sphenoid ridge meningioma, fibrous dysplasia, ossifying fibroma, osteoma and aneurismal bone cyst. Controversies in the treatment strategies still exist. This study is retrospective study that included 20 patients operated upon in the last three years—at neurosurgery department in Minia University Hospital—with tumors related to the bony orbit. We studied the data, to see what was done, what should have been done. CT and MRI were used for all patients preoperatively and for postoperative follow-up.

Results
Fourteen patients had sphenoid ridge meningiomas, two patients had osteomas, two patients had fibrous dysplasia, one had ossifying fibromas and one aneurysmal bone cyst. Proptosis improved in all cases. But one patient had deterioration of vision. There were no postoperative cases of enophthalmos or pulsating exophthalmos.

Conclusions
Early surgical intervention is mandatory before the tumor becomes less amenable. Both CT and MRI should be done preoperatively. Opening the bony superior orbital fissure is a mandatory step in all cases, whereas the optic canal should be drilled out open only if the optic nerve is compromised within the canal. Thorough knowledge of the skull base operative techniques is a must.
Evaluation of brain structure abnormalities in children with autism spectrum disorder (ASD) using structural magnetic resonance imaging
Authors: Khadem-Reza Zahra Khandan , Zare Hoda 
Published: November 2022

AbstractBackgroundAutism spectrum disorder (ASD) is a group of developmental disorders of the nervous system. Since the core cause of many of the symptoms of autism spectrum disorder is due to changes in the structure of the brain, the importance of examining the structural abnormalities of the brain in these disorder becomes apparent. The aim of this study is evaluation of brain structure abnormalities in children with autism spectrum disorder (ASD) using structural magnetic resonance imaging (sMRI). sMRI images of 26 autistic and 26 Healthy control subjects in the range of 5–10 years are selected from the ABIDE database. For a better assessment of structural abnormalities, the surface and volume features are extracted together from this images. Then, the extracted features from both groups were compared with the samplettest and the features with significant differences between the two groups were identified.ResultsThe results of volume-based features indicate an increase in total brain volume and white matter and a change in white and gray matter volume in brain regions of Hammers atlas in the autism group. In addition, the results of surface-based features indicate an increase in mean and standard deviation of cerebral cortex thickness and changes in cerebral cortex thickness, sulcus depth, surface complexity and gyrification index in the brain regions of the Desikan–Killany cortical atlas.ConclusionsIdentifying structurally abnormal areas of the brain and examining their relationship to the clinical features of Autism Spectrum Disorder can pave the way for the correct and early detection of this disorder using structural magnetic resonance imaging. It is also possible to design treatment for autistic people based on the abnormal areas of the brain, and to see the effectiveness of the treatment using imaging.
Horizontal transfer of antibiotic resistance genes into microflora and blood cells in rats fed on GM-diet
Authors: Oraby Hanaa Abdel-Sadek , Aboul-Maaty Nadia Aboul-Ftooh , Al-Sharawi Hayam Ahmad , Osman Noha Mohamed 
Published: November 2022

Abstract
Background
With regard to the extensive production of genetically modified organisms, scientists focused on the safety of antibiotic resistance marker (ARM) genes present in GM-crops produced for the consumption of human or animal. We investigated the possible transfer of these genes to the microflora present in the gastrointestinal tract and blood cells of two groups of Male Wistar Albino rats fed on a transgenic diet containing the ARM genes nptII and aadA for 90 days. The conventional PCR was employed to screen for the presence of nptII and aadA genes in the experimental diets, and animals’ samples.

Results
The occurrence of DNA transfer of nptII and aadA genes from GM-diet to blood and bacterial cells has been unambiguously demonstrated. Results were further confirmed by sequencing and blast analysis, indicating that both transferred segments shared significant alignment with number of Binary and Cloning Vectors with variable similarities. The frequency of transfer of DNA segments from the GM-diet into blood DNA was unexpectedly higher than its transfer to bacterial DNA which may be attributed to a number of factors.

Conclusions
Our results unambiguously demonstrated the occurrence of DNA transfer of ARM genes (nptII and aadA) from GM plant diet to blood cells and enteric microflora in rats. Results may draw attentions to the importance of exploring the possible effects of transfer of ARM genes horizontally from GM products to consumers and to extend our attentions to the importance of a better understanding of the factors influencing HGT in the intestine of the GM-food consumers.
Enteroendocrine peptides, growth, and the microbiome during the porcine weaning transition
Authors: Ramsay T. G. , Arfken A. M. , Summers K. L. 
Published: November 2022

Abstract
Background
Growth rate in pigs can be affected by numerous factors that also affect feeding behavior and the microbiome. Recent studies report some communication between the microbiome and the enteroendocrine system. The present study examined if changes in the piglet microbiome between birth and during the weaning transition can be correlated either positively or negatively with growth rate and plasma concentrations of enteroendocrine peptides.

Results
During the post-weaning transition, a 49% reduction in average daily gain was observed at day 24 (P < 0.05) relative to day 21. Pigs recovered by day 28 with body weight and average daily gain increases of 17% and 175%, respectively relative to day 24 and the highest rate of gain was measured at day 35 (462 g/day). The time interval between day 21–24 had the highest number of correlations (n = 25) between the relative abundance differences in taxa over time and corresponding percent weight gain. Amplicon sequence variants with the greatest correlation with percent weight gain between day 21–24 belonged to families Prevotellaceae NK3B31 (ρ = 0.65, P < 0.001), Veillonellaceae (ρ = 0.63, P < 0.001) and Rikenellaceae RC9 (ρ = 0.62, P < 0.001). Seven taxa were positively correlated with percent weight gain between day 24–28. Eight taxa were positively correlated with percent weight gain between day 28–35, of which four were Clostridia. Only Lactobacillus reuteri was positively correlated across both day 24–28 and day 28–35 analyses. Insulin-like growth factor 1 (IGF-1; R2 = 0.61, P < 0.001), glucose-dependent insulinotropic polypeptide (GIP; R2 = 0.20, P < 0.001), glucagon-like peptide 1 (GLP-1; R2 = 0.51, P < 0.001), and glucagon-like peptide 2 (GLP-2; R2 = 0.21, P < 0.001) were significantly associated with the piglet fecal community NMDS, while serotonin showed no significant association (R2 = 0.03, P = 0.15). Higher concentrations of GLP-1 and GLP-2 characterized day 1 fecal communities, while GIP levels had the strongest relationship primarily with samples ordinated with the day 21 cluster.

Conclusions
Demonstration of an association of certain taxa with individual gut peptides at specific ages suggests the potential for the microbiome to elicit changes in the gut enteroendocrine system during early postnatal development in the pig.
Insight into the mechanism of fracture properties modulated by microstructure in the myofibrillar protein and polysaccharide gel systems
Authors: Luo Cheng , Zhang Tao , Jiang Xiping , Chen Yinji , Zhou Guanghong , Zhuang Xinbo 
Published: November 2022

AbstractThe objective of this study was to investigate the mechanism of fracture properties modulated by microstructure in the myofibrillar protein (MP) and polysaccharides gel systems. Compare to the modified starch, the dietary fiber significantly improved the fracture stress and reduced the fracture strain at same concentration. The treatment with 2% dietary fiber had the highest value of fracture stress and the lowest value of fracture strain, which were 259 g and 1.12 respectively. From the skeleton structure, the Raman spectroscopy result showed that dietary fiber addition significantly reduced the intensity at 2945 cm−1, which suggested that the aggregation of hydrophobic groups was improved. The SEM showed that the treatment with 2% dietary fiber had the highest fractal dimension value of 1.7772 and the lowest lacunary value of 0.258. From the filling structure, the paraffin section showed that the polysaccharides were just simply trapped in MP gel networks and formed numerous large volumes and no-elastic of cavities. The principal component analysis suggested that the compactness of three-dimensional gel networks determined fracture stress of composite gel. The no- no-elastic of cavities formed by modified starch and dietary fiber resulted in the reduction of fracture strain. These results would promote the development of innovative nutritional meat product formulation with satisfied textural property.
Graphical Abstract
Acute poisoning of copper sulfate: a case report and review literature
Authors: Hajimohammadi Samaneh , Gharibi Somayeh , Pourbarkhordar Vahid , Mousavi Seyed Reza , Salmani Izadi Hanieh 
Published: November 2022

AbstractBackgroundCopper sulfate is a bright blue crystal used primarily for agricultural purposes, as a pesticide, disinfectant, feed, and soil additive. Acute volunteer poisoning of copper sulfate is not common in the world and in Iran.Case presentationWe reported the case of a 15-year-old girl who presented to the emergency department after ingestion of an unknown amount of copper sulfate following a struggle at school. She had become acquainted with the toxic compound through school textbooks. On admission to the hospital, she had abdominal pain and a sore throat with a normal serum copper level. The patient stated that she had three episodes of bluish vomiting. She underwent symptomatic treatment and was monitored for 3 days. The outcome was favorable, and she had no signs and symptoms of organ failure.ConclusionsAs a result, copper sulfate poisoning depending on the consumed dose can be mild or very severe with a high mortality rate. The authors discuss the various pathogenesis and treatments of this rare poisoning by reviewing the available literature.
An unusual magnetic phenomenon in Mg doping [(CH3)2NH2] CoxMg1−x[HCOO]3 frameworks
Authors: Fan Zhenjun , Liu Rongzhao , Wang Qingying , Wu Xiangyu , Mi Zhenyu , Liu Guangyao , Song Xiaohui 
Published: November 2022

Abstract
In this study, Mg doping metal-organic frameworks (MOFs) [(CH3)2NH2] Co1−x
Mg
x
[HCOO]3 single crystals were synthesized by solvothermal method with normal ratios x = 0, 0.1, 0.2, 0.3, 0.4, 0.6. Powder X-ray diffraction (XRD), Scanning Electron Microscopy (SEM) and Energy Dispersive X-Ray Spectroscopy (EDX) results showed that Mg ion is uniformly doped into Co-based MOFs crystal. With the increase of diamagnetic magnesium ions doping, the antiferromagnetic phase transition temperature of Co-based MOFs for pure Co-MOF decreased from 15 K to 7.5 K for x = 0.4. Abnormal larger magnetic hysteresis was obtained for Mg doping crystals with a large coercive field 3100 Oe (x = 0.1), 3700 Oe (x = 0.2), 2900 Oe (x = 0.3) compared with 600 Oe coercive field for pure Co-MOFs (x = 0). At the same time, step-like behavior was first observed on Mg2+ doping sample with x = 0.1–0.3. This unusual magnetic phenomenon is well interpreted based on the coexistence of long-range canted antiferromagnetic order and isolated single-ion quantum magnets. The diamagnetic magnesium ions doping decreases the strong exchange coupling between neighboring Co ions and step-like behavior stemmed from the quantum tunneling of isolated Co ions.
Preoperative Identification of Patient-Dependent Blood Pressure Targets Associated With Low Risk of Intraoperative Hypotension During Noncardiac Surgery
Authors: Schnetz Michael P. , Danks David J. , Mahajan Aman 
Published: November 2022

BACKGROUND:
Intraoperative hypotension (IOH) is strongly linked to organ system injuries and postoperative death. Blood pressure itself is a powerful predictor of IOH; however, it is unclear which pressures carry the lowest risk and may be leveraged to prevent subsequent hypotension. Our objective was to develop a model that predicts, before surgery and according to a patient’s unique characteristics, which intraoperative mean arterial pressures (MAPs) between 65 and 100 mm Hg have a low risk of IOH, defined as an MAP <65 mm Hg, and may serve as testable hemodynamic targets to prevent IOH.

METHODS:
Adult, noncardiac surgeries under general anesthesia at 2 tertiary care hospitals of the University of Pittsburgh Medical Center were divided into training and validation cohorts, then assigned into smaller subgroups according to preoperative risk factors. Primary outcome was hypotension risk, defined for each intraoperative MAP value from 65 to 100 mm Hg as the proportion of a value’s total measurements followed by at least 1 MAP <65 mm Hg within 5 or 10 minutes, and calculated for all values in each subgroup. Five models depicting MAP-associated IOH risk were compared according to best fit across subgroups with proportions whose confidence interval was <0.05. For the best fitting model, (1) performance was validated, (2) low-risk MAP targets were identified according to applied benchmarks, and (3) preoperative risk factors were evaluated as predictors of model parameters.

RESULTS:
A total of 166,091 surgeries were included, with 121,032 and 45,059 surgeries containing 5.4 million and 1.9 million MAP measurements included in the training and validation sets, respectively. Thirty-six subgroups with at least 21 eligible proportions (confidence interval <0.05) were identified, representing 92% and 94% of available MAP measurements, respectively. The exponential with theta constant model demonstrated the best fit (weighted sum of squared error 0.0005), and the mean squared error of hypotension risk per MAP did not exceed 0.01% in validation testing. MAP targets ranged between 69 and 90 mm Hg depending on the subgroup and benchmark used. Increased age, higher American Society of Anesthesiologists physical status, and female sexindependently predicted (P < .05) hypotension risk curves with less rapid decay and higher plateaus.

CONCLUSIONS:
We demonstrate that IOH risk specific to a given MAP is patient-dependent, but predictable before surgery. Our model can identify intraoperative MAP targets before surgery predicted to reduce a patient’s exposure to IOH, potentially allowing clinicians to develop more personalized approaches for managing hemodynamics.