bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasmall Superparamagnetic Iron Oxide Nanoparticles Synthesized by
Micellar Approach as a Potential Dual-Mode T1-T2 Contrast Agent
Authors: Varanda Laudemir C. , Beck Watson , Lopes Simone J.S. , Moraes Daniel A. , Santos Natalia M. , S. D. Lino Maria Eduarda 
Published: May 2022

Purpose:
A micellar approach is used to synthesize Ultrasmall Superparamagnetic Iron Oxide Nanoparticles (USPIONs) with an average diameter of 3.4±0.5 nm, suitable for dual-mode T1-T2 contrast agents.

Methods:
Micelles with 3.8 nm, measured by dynamic light scattering, were obtained by self-organizing the surfactant iron(III) dodecyl sulfate (IDS) in 1-octanol. IDS was prepared by replac-ing Na+ cation in sodium dodecyl sulfate molecule, and its critical micelle concentration (CMC) was measured by electrical conductivity. The USPIONs were synthesized in a biphasic system: IDS in octanol (55% above the CMC) and water containing NaBH4.

Results:
A yellow precipitate is immediately formed at the water/alcohol interface, rapidly changes to a black one, and transfers to the aqueous phase. The magnetite phase was confirmed by X-ray diffraction and Mössbauer spectroscopy. The magnetic behavior shows a major paramagnetic char-acter with a weak ferromagnetic component at 5 K, the latter attributed to the interparticle couplings below its blocking temperature (TB = 35 K). The particles were coated with carboxymethyl dextran, showing an isoelectric point of 2.7 with electrokinetic potential around -30 mV in the physiological pH range. Magnetic relaxation measurements showed relaxivity values r1 = 0.17 mM-1 s-1 and r2 = 1.73 mM-1 s-1 (r2/r1 = 10) in a 3T field. These values infer that the ultrasmall size affects the interac-tions with the protons of the nearby water molecules. The r2 value decreases because the core mag-netization decreases with size; r1 intensifies due to the high surface.

Conclusion:
The results show a system with high colloidal stability, non-cytotoxic, and potential application as T1-T2 dual-mode contrast agents.
Design of a Remote Coaching Program to Bridge the Gap From Hospital Discharge to Cardiac Rehabilitation: Intervention Mapping Study
Authors: Keessen Paul , van Duijvenbode Ingrid CD , Latour Corine HM , Kraaijenhagen Roderik A , Janssen Veronica R , Jørstad Harald T , Scholte op Reimer Wilma JM , Visser Bart 
Published: May 2022

Background
Remote coaching might be suited for providing information and support to patients with coronary artery disease (CAD) in the vulnerable phase between hospital discharge and the start of cardiac rehabilitation (CR).

Objective
The goal of the research was to explore and summarize information and support needs of patients with CAD and develop an early remote coaching program providing tailored information and support.

Methods
We used the intervention mapping approach to develop a remote coaching program. Three steps were completed in this study: (1) identification of information and support needs in patients with CAD, using an exploratory literature study and semistructured interviews, (2) definition of program objectives, and (3) selection of theory-based methods and practical intervention strategies.

Results
Our exploratory literature study (n=38) and semistructured interviews (n=17) identified that after hospital discharge, patients with CAD report a need for tailored information and support about CAD itself and the specific treatment procedures, medication and side effects, physical activity, and psychological distress. Based on the preceding steps, we defined the following program objectives: (1) patients gain knowledge on how CAD and revascularization affect their bodies and health, (2) patients gain knowledge about medication and side effects and adhere to their treatment plan, (3) patients know which daily physical activities they can and can’t do safely after hospital discharge and are physically active, and (4) patients know the psychosocial consequences of CAD and know how to discriminate between harmful and harmless body signals. Based on the preceding steps, a remote coaching program was developed with the theory of health behavior change as a theoretical framework with behavioral counseling and video modeling as practical strategies for the program.

Conclusions
This study shows that after (acute) cardiac hospitalization, patients are in need of information and support about CAD and revascularization, medication and side effects, physical activity, and psychological distress. In this study, we present the design of an early remote coaching program based on the needs of patients with CAD. The development of this program constitutes a step in the process of bridging the gap from hospital discharge to start of CR.
Virtual Reality Intervention for Managing Apathy in People With Cognitive Impairment: Systematic Review
Authors: Ho Ka Ying , Cheung Po Mang , Cheng Tap Wing , Suen Wing Yin , Ho Hiu Ying , Cheung Daphne Sze Ki 
Published: May 2022

Background
Apathy is common in people with cognitive impairment. It leads to different consequences, such as more severe cognitive deficits, rapid functional decline, and decreased quality of life. Virtual reality (VR) interventions are increasingly being used to manage apathy in individuals with cognitive impairment. However, reports of VR interventions are scattered across studies, which has hindered the development and use of the interventions.

Objective
This study aimed to systematically review existing evidence on the use of VR interventions for managing apathy in people with cognitive impairment with regard to the effectiveness, contents, and implementation of the interventions.

Methods
The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed. The PubMed, Embase, CINAHL, and PsycINFO databases were systematically searched for experimental studies published up to March 13, 2022, that reported the effects of VR interventions on apathy in older adults with cognitive impairment. Hand searching and citation chasing were conducted. The results of the included studies were synthesized by using a narrative synthesis. Their quality was appraised by using the Effective Public Health Practice Project quality assessment tool. However, because the VR interventions varied in duration, content, and implementation across studies, a meta-analysis was not conducted.

Results
A total of 22 studies were identified from the databases, of which 6 (27%) met the inclusion criteria. Of these 6 studies, 2 (33%) were randomized controlled trials, 1 (17%) was a controlled clinical trial, and 3 (50%) were quasi-experimental studies. Individual studies showed significant improvement in apathy and yielded within-group medium to large effect sizes. The level of immersion ranged from low to high. Minor adverse effects were reported. The VR content mostly included natural scenes, followed by city views and game-based activities. A background soundtrack was often used with natural scenes. Most (5/6, 83%) of the studies were conducted in a residential care setting and were implemented by health care professionals or researchers. Safety precautions were taken in most (5/6, 83%) of the studies.

Conclusions
Although preliminary evidence shows that VR interventions may be effective and feasible for alleviating apathy in people with cognitive impairment, the methodological limitations in the included studies make it difficult to reach a firm conclusion on these points. The implementation of the interventions was highlighted and discussed. More rigorous studies are encouraged.

Trial Registration
PROSPERO International Prospective Register of Systematic Reviews CRD42021268289; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021268289
Imam Ali Ibn Musa al-Ridha (A. S.)-The Exquisite Sun of Bani Hashim
Authors: Dr. Syeda Farhat Fatima  
Published: May 2022

Ali Ibn Musa al-Rida was the eighth great grandson of Fatima Zehra (daughter of Prophet Mohammad, peace be upon him) and Ali Ibn Abi Talib and he is also the eighth Imam of Shiite believers. He was an embodiment of etiquette, manners and charity and he imparted to us the qualities of a believer. His teachings were ‘How a man should strive to be a believer of Allah (S.w.t)?’He highlighted in his preaching’s the ways to seek the pleasure of Allah (s.w.t) was through piousness, tolerance and persistence in our righteous deeds. He also emphasized us that for a believer to control his/her nafs (psyche)is prominent among his actions. Because of Imam Ali Ridha’s (a. s.) high moral traits and pleasing personality, he (a. s.) was considered the exquisite sun of Bibi Fatima Zehra and the Bani Hashim clan. This paper aims to show that Imam Ali Ibn Musa al-Ridha’s reward from Allah (s.w.t) is complete peace of mind as he stuck to his spiritual values being away from his homeland
Clinicopathologic findings and urolith composition for green iguanas (Iguana iguana) with urolithiasis: 21 cases and 132 stones (1996–2020)
Authors: Cerreta Anthony J. , Keller Krista A. , Gardhouse Sara M. , Lulich Jody P. , Guzman David Sanchez-Migallon 
Published: May 2022

Abstract

OBJECTIVE
To document the clinical signs, diagnosis, and treatment of urolithiasis in green iguanas (Iguana iguana) and to report on the composition of uroliths from green iguanas submitted to the Minnesota Urolith Center for analysis.

ANIMALS
21 green iguanas with urolithiasis.

PROCEDURES
Medical record databases of multiple veterinary teaching hospitals were searched from 1996 through 2020. Emails were sent to all facilities that submitted a urolith from a green iguana to the Minnesota Urolith Center from 1996 through 2020. Signalment; presenting complaint; physical examination findings; hematologic, biochemical, and diagnostic imaging findings; treatment; necropsy results; and survival times were described for each patient.

RESULTS
Iguanas most commonly presented with nonspecific clinical signs, but 9 of the 21 iguanas had clinical signs associated with the urogenital tract. Twelve iguanas had a palpable mass in the caudal coelom. All uroliths were visible on radiographs. Surgery was performed on 15 iguanas; 3 died secondary to intra- or postoperative complications. Iguanas that underwent surgery had a median survival time of 39 months. Necropsy was performed on 5 iguanas, and urolithiasis contributed to the decision to euthanize or was the cause of death for 4. Uroliths from 132 iguanas were analyzed, and all were composed of 100% uric acid salts.

CLINICAL RELEVANCE
Green iguanas with urolithiasis may not have clinical signs or physical examination findings associated with the urinary system, and hematologic and biochemical abnormalities are nonspecific. Green iguanas should be routinely examined for uroliths, and surgical treatment should be pursued.
Development of the Smart T-Shirt for Monitoring Thermal Status of Athletes
Authors: Stojanović Sandra , Geršak Jelka , Uran Suzana 
Published: May 2022

Abstract
Athletes are often subjected to a great physical strain during training and competition. Sport activities performed in hot and humid conditions may result in different heat illnesses with mild or fatal consequences. Against this background it is important to know the thermal state of athletes during physical activity.
This article presents the development of a smart T-shirt for monitoring the thermal status of an athlete. The smart T-shirt was created by embedding an electronic system with temperature and humidity sensors that allows the measurement of temperature and the relative humidity of the microclimate. A smart T-shirt is comfortable, and integrated sensors and electronics do not affect wearing comfort. A good concurrence between the temperature and humidity results from using the smart T-shirt, and thus the medical device was achieved. Data obtained can be of great importance to the sports staff who will be able to monitor the athletes' thermal state during matches and competitions.
No escape from COVID-19 consequences: cross-sectoral evaluation of impact on unemployment in Slovakia
Authors: Svabova Lucia , Tesarova Eva Nahalkova , Strakova Lenka , Durica Marek 
Published: May 2022

Abstract
The coronavirus disease 2019 (COVID-19) pandemic, which hit the world in 2020 and is still persisting, has significantly impacted many areas of people's lives. The shutdown anti-pandemic measures implemented by the governments also caused the development of unemployment worldwide. In Slovakia, the restrictions or even complete closure of the operation and activities of the companies caused rising unemployment in some sectors, while in some sectors, the impact was not so substantial. Therefore, the main aim of this study was to analyse and quantify the impact of COVID-19 pandemic on unemployment in various sectors of economic activities in Slovakia. For impact evaluation, a counterfactual approach was used, with analysis of time series development and statistically created counterfactual situation. The analysis was based on real data about the unemployment situation in Slovakia in the period January 2013–April 2021. The results of the study showed that the most affected sectors according to the NACE classification were F – construction, I – accommodation and food service activities and R – arts, entertainment and recreation, showing an increase in unemployment of 89%, 88%, and 65%, respectively. The analysis in this study showed that the impact of a pandemic should be quantified among the sectors, as there are large differences in unemployment caused by the pandemic. From these findings, it is necessary to deduce the different intensities and amount of state aid to companies or employees in these sectors. The results of the study should help to target the policy interventions better to mitigate the impact of the pandemic.
RAF-1 Mutation Associated with a Risk for Ventricular Arrhythmias in a Child with Noonan Syndrome and Cardiovascular Pathology
Authors: Făgărășan Amalia , Al Hussein Hamida , Ghiragosian Rusu Simina Elena 
Published: May 2022

Abstract

Introduction
Noonan syndrome (NS) is a dominant autosomal disease, caused by mutations in genes involved in cell differentiation, growth and senescence, one of them being RAF1 mutation. Congenital heart disease may influence the prognosis of the disease.

Case presentation
We report a case of an 18 month-old female patient who presented to our institute at the age of 2 months when she was diagnosed with obstructive hypertrophic cardiomyopathy, pulmonary infundibular and pulmonary valve stenosis, a small atrial septal defect and extrasystolic arrhythmia. She was born from healthy parents, a non-consanguineous marriage. Due to suggestive phenotype for NS molecular genetic testing for RASopathies was performed in a center abroad, establishing the presence of RAF-1 mutation. Following rapid progression of cardiac abnormalities, the surgical correction was performed at 14 months of age. In the early postoperative period, the patient developed episodes of sustained ventricular tachycardia with hemodynamic instability, for which associated treatment was instituted with successful conversion to sinus rhythm. At 3-month follow-up, the patient was hemodynamically stable in sinus rhythm.

Conclusions
The presented case report certifies the importance of recognizing the genetic mutation in patients with NS, which allows predicting the severity of cardiac abnormalities and therefore establishing a proper therapeutic management of these patients.
Renal Manifestations and their Association with Mortality and Length of Stay in COVID-19 Patients at a Safety-net Hospital
Authors: Gomez-Paz Sandra , Lam Eric , Gonzalez-Mosquera Luis , Cardenas-Maldonado Diana , Fogel Joshua , Gabrielle Kagan Ellen , Rubinstein Sofia 
Published: May 2022

Abstract

Background
Renal involvement in COVID-19 leads to severe disease and higher mortality. We study renal parameters in COVID-19 patients and their association with mortality and length of stay in hospital.

Methods
A retrospective study (n=340) of confirmed COVID-19 patients with renal involvement determined by the presence of acute kidney injury. Multivariate analyses of logistic regression for mortality and linear regression for length of stay (LOS) adjusted for relevant demographic, comorbidity, disease severity, and treatment covariates.

Results
Mortality was 54.4% and mean LOS was 12.9 days. For mortality, creatinine peak (OR:35.27, 95% CI:2.81, 442.06, p<0.01) and persistent renal involvement at discharge (OR:4.47, 95% CI:1.99,10.06, p<0.001) were each significantly associated with increased odds for mortality. Increased blood urea nitrogen peak (OR:0.98, 95%CI:0.97,0.996, p<0.05) was significantly associated with decreased odds for mortality. For LOS, increased blood urea nitrogen peak (B:0.001, SE:<0.001, p<0.01), renal replacement therapy (B:0.19, SE:0.06, p<0.01), and increased days to acute kidney injury (B:0.19, SE:0.05, p<0.001) were each significantly associated with increased length of stay.

Conclusion
Our study emphasizes the importance in identifying renal involvement parameters in COVID-19 patients. These parameters are associated with LOS and mortality, and may assist clinicians to prognosticate COVID-19 patients with renal involvement.
Dystopian Futures: Ugandan Science Fiction and Post-Apocalypse Contagions
Authors: Nabutanyi Edgar Fred 
Published: May 2022

Uganda, like most countries on the African continent, has in the recent past grappled with existential pandemics such as AIDS, Marburg disease, cholera, Ebola, and currently the Covid-19 pandemic. All the above-mentioned disease outbreaks have often unleashed unimaginable suffering on Uganda’s population. This is perhaps why Ugandan scholars and public intellectuals—especially its writers such as Mary Karooro Okurut, Moses Isegawa, Jennifer Nansubuga Makumbi, and Austin Ejeit—have used fiction to offer insights into the various contours of these contagions. For example, in their interrogation of one of the worst pandemics to hit the Ugandan society—AIDS—a host of writers have centred a cautionary tale motif and verisimilitude to show how behavioural change can effectively combat disease outbreaks. This article builds on this substantial Ugandan archive of plague writing by focusing on one genre of Ugandan writing—science fiction—that has not received much critical attention for its exploration of pandemics. I explore how Dilman Dila’s “A Leafy Man,” “Where Rivers Go to Die” and “The Taking of Oleng” use science fiction tropes to proffer insights in contemporary Ugandan plagues. I argue that Dila uses science fiction to effectively delineate the causes of, how to cope with and the myths that circulate about these catastrophic occurrences in the Ugandan public sphere. Opsomming Soos die meeste lande op die Afrika-vasteland het Uganda onlangs met eksistensiële pandemies soos vigs, Marburg, cholera en ebola geworstel, benewens die huidige Covid-19-pandemie. Al die bogenoemde siekte-uitbrekings het dikwels ondenkbare lyding vir Uganda se bevolking meegebring. Dalk is dit die rede waarom Ugandese vakkundiges en openbare intellektuele—veral skrywers soos Mary Karooro Okurut, Moses Isegawa, Jennifer Nansubuga Makumbi, en Austin Ejeit—fiksie gebruik het om insig in die verskillende kontoere van hierdie besmettings te bied. Byvoorbeeld, in hul ondersoeke oor een van die ergste pandemies wat die Ugandese samelewing getref het, naamlik vigs, het vele skrywers ’n waarskuwende verhaalmotief en skynwaarheid die middelpunt gemaak om te wys hoe gedragsverandering die uitbreking van siektes doeltreffend kan bekamp. Hierdie artikel bou voort op dié omvattende Ugandese argief van skryfwerk oor siektes, deur te fokus op een genre van Ugandese skryfwerk—wetenskapsfiksie—wat nie veel kritiese aandag gekry het vir die bestudering van pandemies nie. Ek ondersoek hoe Dilman Dila se “A Leafy Man,” “Where Rivers Go to Die” en “The Taking of Oleng” wetenskapsfiksie-stylfigure gebruik om insig oor hedendaagse Ugandese plae te bied. Ek voer aan dat Dila wetenskapsfiksie gebruik om ’n doeltreffende beeld te skep van die oorsake van hierdie katastrofiese verskynsels wat in die Ugandese openbare sfeer sirkuleer, hoe om dit te hanteer en die mites daaromtrent.
Single Centre Experience: Bening and Malign Hematological Patients with COVID-19
Authors: TIĞLIOĞLU Pınar , ALBAYRAK Murat , AFACAN ÖZTÜRK Hacer Berna , TIĞLIOĞLU Mesut , SAĞLAM Buğra , REİS ARAS Merih , YILMAZ Fatma , MARAL Senem , MALKAN Ümit Yavuz 
Published: May 2022

Introduction
Coronavirus disease 2019 (COVID-19) were declared as pandemic by World Health Organization. With this study, we aimed to define our patients who were followed up with malign or benign hematological diagnoses and diagnosed with COVID-19; determine the distribution of this infection in patient groups and contribute to the literature by creating descriptive statistics with its clinical and demographic features.
Patients and methods:
It is planned to retrospectively examine patients with a history of COVID-19 who were followed up in Hematology Department of Dışkapı Yıldırım Beyazıt Training and Research Hospital with benign and malignant diagnoses.
Results:
88 patients who had COVID-19 infection while being followed in our clinic due to hematological diseases were included in the study. 77 patients had been followed by hematologic malignancies and 11 patients had been followed by benign hematological disease.In the group with malignancy, COVID was found most frequently in patients diagnosed with Philadelphia chromosome negative myeloproliferative neoplasms (22%), nonhodgkin lymphoma (19%) and multiple myeloma (16%). ITP (64%) was the most common disease in patients with benign hematological disorder who had COVID history. 52 (67%) of the malignant cases and 8 (73%) of the bening cases were found to be followed up with the disease in remission.
The all patient's most common symptoms at COVID-19 diagnosis were fever (77%), cough (70%) and weakness (65%). 45% of the patients were isolated at home, 48% were required hospitalization. 49% of patients had mild; 27% had moderate and 24% had severe COVID-19 infection. Almost all of the patients in the moderate and severe disease group were followed up in patients diagnosed with malignant hematological disease. 16 (18%) patients received mechanical ventilation and 16 (18%) patients was transferred intensive care unit. All of the patients who were intubated and needed intensive care were diagnosed with malignant hematological disease. 17 patients died due to COVID-19 infection. The mortality rate was 22% in patients with diagnosis of malignant hematological diseases, and 19% when all patients (malignant and bening) were included.
Conclusion:
In conclusion, the COVID-19 pandemic is a problem all over the world. Determining the course of the disease in certain diagnostic groups is important in the management of both the main disease and the COVID-19 infection. Therefore, the contribution of such recording studies to the literature is important and valuable.