bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bayesian evidence-driven diagnosis of instrumental systematics for sky-averaged 21-cm cosmology experiments
Authors: Scheutwinkel K. H. , de Lera Acedo E. , Handley W. 
Published: October 2022

AbstractWe demonstrate the effectiveness of a Bayesian evidence -based analysis for diagnosing and disentangling the sky-averaged 21-cm signal from instrumental systematic effects. As a case study, we consider a simulated REACH pipeline with an injected systematic. We demonstrate that very poor performance or erroneous signal recovery is achieved if the systematic remains unmodelled. These effects include sky-averaged 21-cm posterior estimates resembling a very deep or wide signal. However, when including parameterised models of the systematic, the signal recovery is dramatically improved in performance. Most importantly, a Bayesian evidence-based model comparison is capable of determining whether or not such a systematic model is needed as the true underlying generative model of an experimental dataset is in principle unknown. We, therefore, advocate a pipeline capable of testing a variety of potential systematic errors with the Bayesian evidence acting as the mechanism for detecting their presence.
The use of evacuation modelling techniques in the design of very large transport aircraft and blended wing body aircraft
Authors: Galea E. R. , Blake S. J. , Gwynne S. , Lawrence P. J. 
Published: October 2022

AbstractVery Large Transport Aircraft (VLTA) pose considerable challenges to designers, operators and certification authorities. Questions concerning seating arrangement, nature and design of recreational space, the number, design and location of internal staircases, the number of cabin crew required and the nature of the cabin crew emergency procedures are just some of the issues that need to be addressed. Other more radical concepts such as blended wing body (BWB) design, involving one or two decks with possibly four or more aisles offer even greater challenges. Can the largest exits currently available cope with passenger flow arising from four or five aisles? Do we need to consider new concepts in exit design? Should the main aisles be made wider to accommodate more passengers? In this paper we demonstrate how computer based evacuation models can be used to investigate these issues through examination of staircase evacuation procedures for VLTA and aisle/exit configuration for BWB cabin layouts.
Aircraft airworthiness certification standards for civil UAVs
Authors: Haddon D. R. , Whittaker C. J. 
Published: October 2022

AbstractThe CAA has recognised the need to develop civil standards for unmanned aerial vehicles (UAVs). Accordingly the CAA Directorate of Airspace Policy has published the document ‘CAP 722 –Unmanned Air Vehicle Operation in UK Airspace – Guidance’, (which can be accessed via the CAA website — http://www.caa.co.uk/docs/33/CAP722.pdf). The document itemises the top-level military and civil regulations which impact upon the operation of UAVs in the UK. One of the items listed within the document is ‘Civil Certification’ of UAVs. This particular aspect is the responsibility of the Design and Production Standards Division, (D&PSD), of the CAA Safety Regulation Group. The purpose of this paper is to present and explain the current position of D&PSD regarding the appropriate design standards to be applied for the civil certification of the airworthiness of UAVs.This paper presents the CAA position that UAVs should be granted permission to fly by qualifying for certificates of airworthiness, by demonstration of compliance with defined airworthiness standards comparable to, and derived from, those applied to manned aircraft. The paper also presents a method for determining, to a first approximation, the level of airworthiness standards which should be applied to any particular design of UAV by reference to the existing codes of airworthiness requirements for manned aircraft.
Heat transfer and flow behind a step in high enthalpy superorbital flow
Authors: Hayne M. J. , Mee D. J. , Morgan R. G. , Gai S. L. , Mclntyre T. J. 
Published: October 2022

AbstractHeat transfer levels have been investigated behind a rearward-facing step in a superorbital expansion tube. The heat transfer was measured along a flat plate and behind 2 and 3mm steps with the same length to step height ratio. Results were obtained with air as the test gas at speeds of 6·76kms-1and 9·60kms-1corresponding to stagnation enthalpies of 26MJ/kg and 48MJ/kg respectively. A laminar boundary layer was established on the flat plate and measured heat transfer levels were consistent with classical empirical correlations. In the case of flow behind a step, the measurements showed a gradual rise in heat transfer from the rear of the step to a plateau several step heights downstream for both flow conditions. Reattachment distance was estimated to be approximately 1·6 step heights downstream of the 2mm step at the low enthalpy condition through the use of flow visualisation.
Saltwater Intrusion‐Induced Flow Reversal in the Changjiang Estuary
Authors: Ge Jianzhong , Lu Jiayu , Zhang Jingsi , Chen Changsheng , Liu Anqi , Ding Pingxing 
Published: October 2022

AbstractSaltwater intrusion is a common feature in the Changjiang Estuary affected by river discharges and tidal flows. It leads to a two‐layer flow structure during the flood‐to‐ebb tidal transient period: the seaward tidal flow in the upper water column and onshore intruded salt flow in the lower column, even though the lower column water usually experiences an ebb flow eventually. Our recent measurements with a tripod deployed in a tidal channel of the North Branch in the East China Sea challenged this feature. We detected that the two‐layer flow structure disappeared in the ebb tide period during the neap cycle due to intense saltwater intrusion. A constant onshore flood‐like flow predominated the entire water column. The physical mechanism for the flow reversal was examined using the Finite Volume Community Ocean Model (FVCOM). The FVCOM was robust to capture the observed flow reversal in the tidal channel during the neap tidal cycle. The momentum balance analysis results suggest that the flow reversal occurred when the saltwater intrusion‐induced onshore baroclinic pressure gradient force and baroclinic tidal rectification overwhelmed the seaward barotropic pressure gradient force. A parameter‐driven criterion was derived theoretically to determine the potential occurrence of a stable ebb flow reversal in the tidal channel.
Metamorphism and Deformation on Subduction Interfaces: 1. Physical Framework
Authors: England Philip C. , Smye Andrew J. 
Published: October 2022

AbstractA thermal and mechanical framework is presented for analysis of pressure‐temperature (P‐T) data and structural observations from high‐pressure‐low‐temperature (HPLT) terrains. P‐T data from 281 HPLT rocks exhibit two regimes separated at a pressure of ∼1.5 GPa, which corresponds to the modal maximum depth of thrust faulting in subduction zones. At pressures ≲1.5 GPa, interpreted as recording conditions on the plate interface, temperatures increase at about 350°C/GPa and are consistent with conditions calculated for shear stresses of ∼30–100 MPa on the interface. Such shear stresses are high enough to carry several kilometers' thickness of sediment at least to the base of the plate interface. Burial of material on plate interfaces occurs predominantly during large‐to‐great earthquakes; the exhumation phase involves contrasts in ascent rates of adjacent units, because of their differing buoyancies and strengths. In consequence, juxtaposition of unrelated rock types is expected to be ubiquitous, during both descent and ascent. The scarcity of temperatures higher than ∼650°C at pressures ≳1.5 GPa may reflect loss of material from the wedge‐slab interface by buoyant ascent. Exhumation of rocks in the subduction interface requires substantial reduction in shear stress, most plausibly by (near‐)cessation of subduction. During prograde metamorphism temperatures increase smoothly with depth in the plate interface, with almost isothermal compression in the wedge‐slab interface. Following cessation of subduction, rocks rising along the wedge‐slab interface are likely to heat slightly during decompression. Within the plate interface, temperatures drop following the cessation of shear heating, and rocks follow counter‐clockwise hairpin PT paths.
Ionospheric Plasma Depletions at Mars Observed by the MAVEN Spacecraft
Authors: Basuvaraj Praveen , Němec František , Němeček Zdeněk , Šafránková Jana 
Published: October 2022

AbstractThe Martian ionosphere, modulated by the solar wind from the topside and remnant crustal magnetic fields close to the surface, possesses unique structures different from Earth and Venus. Integrated observations by the plasma and magnetic field instruments onboard the Mars Atmosphere and Volatile Evolution spacecraft show evidence of ionospheric plasma depletions, independent of seasonal variations at Mars. During such depletions, the density of all ionospheric ion species is reduced by more than an order of magnitude, and, at the same time, the electron temperature increases abruptly. An automated algorithm for the identification of such plasma depletions is developed. Altogether, as many as 1,125 events are identified in 8,618 orbits available from October 2014 to May 2021. A statistical investigation of these events reveals that they are more prominent on the nightside, where they seem to occur primarily in the southern hemisphere, possibly in regions with strong crustal magnetic fields. While the dayside events occur mainly at altitudes above about 250 km, nightside event altitudes are typically lower. Considering the relation between spacecraft velocity and observed event duration, we suggest that the depletions are bubble‐like structures, more elongated horizontally than vertically. A possible mechanism of their formation is discussed.
Increased suicide risk among younger women in winter during full moon in northern Europe. An artifact or a novel finding?
Authors: Plöderl Martin , Westerlund Joakim , Hökby Sebastian , Hadlaczky Gergö , Hengartner Michael Pascal 
Published: October 2022

AbstractAvailable evidence suggests that there is no effect of moon phases on suicidal behavior. However, a Finnish study recently reported elevated suicide rates during full-moon, but only among premenopausal women and only in winter. This could not be replicated in an Austrian study and stirred a discussion about whether the Finnish finding was false-positive or if there are unaccounted moderator variables differing between Finland and Austria. The goal of the present study was to provide another replication with data from Sweden, which is geographically more comparable to Finland than Austria. We also investigated the discussed moderator variables latitude and nightly artificial brightness. There were 48,537 suicides available for analysis. The fraction of suicides during the full-moon quarter in winter did not differ significantly from the expected 25% among premenopausal women (23.3%) and in the full sample (24.7%). The incidence risk ratios for full moon quarter in Poisson regression models were 0.96 (95% CI: 0.90–1.02) for premenopausal women and 1.01 (95% CI: 0.99–1.04) for the full sample. According to Bayes-factor analysis, the evidence supports the null-hypothesis (no association) over the alternative hypothesis (some association). We found similar results when we split the data by latitude and artificial nightly brightness, respectively. In line with the Austrian study, there was no increase of suicides in Sweden among premenopausal women in winter during full-moon. The results from the Finnish study are likely false positive, perhaps resulting from problematic but common research and publication practices, which we discuss.
Inefficient white matter activity in Schizophrenia evoked during intra and inter-hemispheric communication
Authors: Zovetti Niccolò , Bellani Marcella , Chowdury Asadur , Alessandrini Franco , Zoccatelli Giada , Perlini Cinzia , Ricciardi Giuseppe K. , Marzi Carlo A. , Diwadkar Vaibhav A. , Brambilla Paolo 
Published: October 2022

AbstractIntensive cognitive tasks induce inefficient regional and network responses in schizophrenia (SCZ). fMRI-based studies have naturally focused on gray matter, but appropriately titrated visuo-motor integration tasks reliably activate inter- and intra-hemispheric white matter pathways. Such tasks can assess network inefficiency without demanding intensive cognitive effort. Here, we provide the first application of this framework to the study of white matter functional responses in SCZ. Event-related fMRI data were acquired from 28 patients (nine females, mean age 43.3, ±11.7) and 28 age- and gender-comparable controls (nine females, mean age 42.1 ± 10.1), using the Poffenberger paradigm, a rapid visual detection task used to induce intra- (ipsi-lateral visual and motor cortex) or inter-hemispheric (contra-lateral visual and motor cortex) transfer. fMRI data were pre- and post-processed to reliably isolate activations in white matter, using probabilistic tractography-based white matter tracts. For intra- and inter-hemispheric transfer conditions, SCZ evinced hyper-activations in longitudinal and transverse white matter tracts, with hyper-activation in sub-regions of the corpus callosum primarily observed during inter-hemispheric transfer. Evidence for the functional inefficiency of white matter was observed in conjunction with small (~50 ms) but significant increases in response times. Functional inefficiencies in SCZ are (1) observable in white matter, with the degree of inefficiency contextually related to task-conditions, and (2) are evoked by simple detection tasks without intense cognitive processing. These cumulative results while expanding our understanding of this dys-connection syndrome, also extend the search of biomarkers beyond the traditional realm of fMRI studies of gray matter.
Neural substrates of reward anticipation and outcome in schizophrenia: a meta-analysis of fMRI findings in the monetary incentive delay task
Authors: Zeng Jianguang , Yan Jiangnan , Cao Hengyi , Su Yueyue , Song Yuan , Luo Ya , Yang Xun 
Published: October 2022

AbstractDysfunction of the mesocorticolimbic dopaminergic reward system is a core feature of schizophrenia (SZ), yet its precise contributions to different stages of reward processing and their relevance to disease symptomology are not fully understood. We performed a coordinate-based meta-analysis, using the monetary incentive delay task, to identify which brain regions are implicated in different reward phases in functional magnetic resonance imaging in SZ. A total of 17 studies (368 SZ and 428 controls) were included in the reward anticipation, and 10 studies (229 SZ and 281 controls) were included in the reward outcome. Our meta-analysis revealed that during anticipation, patients showed hypoactivation in the striatum, anterior cingulate cortex, median cingulate cortex (MCC), amygdala, precentral gyrus, and superior temporal gyrus compared with controls. Striatum hypoactivation was negatively associated with negative symptoms and positively associated with the proportion of second-generation antipsychotic users (percentage of SGA users). During outcome, patients displayed hyperactivation in the striatum, insula, amygdala, hippocampus, parahippocampal gyrus, cerebellum, postcentral gyrus, and MCC, and hypoactivation in the dorsolateral prefrontal cortex (DLPFC) and medial prefrontal cortex (mPFC). Hypoactivity of mPFC during outcome was negatively associated with positive symptoms. Moderator analysis showed that the percentage of SGA users was a significant moderator of the association between symptom severity and brain activity in both the anticipation and outcome stages. Our findings identified the neural substrates for different reward phases in SZ and may help explain the neuropathological mechanisms underlying reward processing deficits in the disorder.
Contrasting life-history responses to climate variability in eastern and western North Pacific sardine populations
Authors: Sakamoto Tatsuya , Takahashi Motomitsu , Chung Ming-Tsung , Rykaczewski Ryan R. , Komatsu Kosei , Shirai Kotaro , Ishimura Toyoho , Higuchi Tomihiko 
Published: October 2022

AbstractMassive populations of sardines inhabit both the western and eastern boundaries of the world’s subtropical ocean basins, supporting both commercial fisheries and populations of marine predators. Sardine populations in western and eastern boundary current systems have responded oppositely to decadal scale anomalies in ocean temperature, but the mechanism for differing variability has remained unclear. Here, based on otolith microstructure and high-resolution stable isotope analyses, we show that habitat temperature, early life growth rates, energy expenditure, metabolically optimal temperature, and, most importantly, the relationship between growth rate and temperature are remarkably different between the two subpopulations in the western and eastern North Pacific. Varying metabolic responses to environmental changes partly explain the contrasting growth responses. Consistent differences in the life-history traits are observed between subpopulations in the western and eastern boundary current systems around South Africa. These growth and survival characteristics can facilitate the contrasting responses of sardine populations to climate change.
Cascade cyclization of alkene-tethered acylsilanes and allylic sulfones enabled by unproductive energy transfer photocatalysis
Authors: Zhang Yunxiao , Zhang Yizhi , Ye Chen , Qi Xiaotian , Wu Li-Zhu , Shen Xiao 
Published: October 2022

AbstractDeveloping photo-induced cascade cyclization of alkene-tethered acylsilanes is challenging, because acylsilanes are unstable under light irradiation. Herein, we report that the energy transfer from excited acylsilanes to a photocatalyst that possesses lower triplet energy can inhibit the undesired decomposition of acylsilanes. With neutral Eosin Y as the photocatalyst, an efficient synthesis of cyclopentanol derivatives is achieved with alkene-tethered acylsilanes and allylic sulfones. The reaction shows broad substrate scope and the synthetic potential of this transformation is highlighted by the construction of cyclopentanol derivatives which contain fused-ring or bridged-ring.
Ex vivo engineered human plasma cells exhibit robust protein secretion and long-term engraftment in vivo
Authors: Cheng Rene Yu-Hong , Hung King L. , Zhang Tingting , Stoffers Claire M. , Ott Andee R. , Suchland Emmaline R. , Camp Nathan D. , Khan Iram F. , Singh Swati , Yang Ying-Jen , Rawlings David J. , James Richard G. 
Published: October 2022

AbstractDue to their unique longevity and capacity to secrete high levels of protein, plasma B cells have the potential to be used as a cell therapy for protein replacement. Here, we show that ex vivo engineered human plasma cells exhibit single-cell RNA profiles, scanning electron micrograph ultrastructural features, and in vivo homing capacity of long-lived plasma cells. After transferring human plasma cells to immunodeficient mice in the presence of the human cytokines BAFF and IL-6, we observe increases in retention of plasma cells in the bone marrow, with engraftment exceeding a year. The most profound in vivo effects of human IL-6 are observed within 20 days of transfer and could be explained by decreased apoptosis in newly differentiated plasma cells. Collectively, these results show that ex vivo engineered and differentiated human plasma cells have the potential for long-lived in vivo protein secretion, which can be modeled in small animals.
ATF4-dependent fructolysis fuels growth of glioblastoma multiforme
Authors: Chen Chao , Zhang Zhenxing , Liu Caiyun , Wang Bin , Liu Ping , Fang Shu , Yang Fan , You Yongping , Li Xinjian 
Published: October 2022

AbstractExcessive consumption of fructose in the Western diet contributes to cancer development. However, it is still unclear how cancer cells coordinate glucose and fructose metabolism during tumor malignant progression. We demonstrate here that glioblastoma multiforme (GBM) cells switch their energy supply from glycolysis to fructolysis in response to glucose deprivation. Mechanistically, glucose deprivation induces expression of two essential fructolytic proteins GLUT5 and ALDOB through selectively activating translation of activating transcription factor 4 (ATF4). Functionally, genetic or pharmacological disruption of ATF4-dependent fructolysis significantly inhibits growth and colony formation of GBM cells in vitro and GBM growth in vivo. In addition, ATF4, GLUT5, and ALDOB levels positively correlate with each other in GBM specimens and are poor prognostic indicators in GBM patients. This work highlights ATF4-dependent fructolysis as a metabolic feature and a potential therapeutic target for GBM.
HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia
Authors: Dong Qianze , Xiu Yan , Wang Yang , Hodgson Christina , Borcherding Nick , Jordan Craig , Buchanan Jane , Taylor Eric , Wagner Brett , Leidinger Mariah , Holman Carol , Thiele Dennis J. , O’Brien Sean , Xue Hai-hui , Zhao Jinming , Li Qingchang , Meyerson Howard , Boyce Brendan F. , Zhao Chen 
Published: October 2022

AbstractAcute myeloid leukemia (AML) is maintained by self-renewing leukemic stem cells (LSCs). A fundamental problem in treating AML is that conventional therapy fails to eliminate LSCs, which can reinitiate leukemia. Heat shock transcription factor 1 (HSF1), a central regulator of the stress response, has emerged as an important target in cancer therapy. Using genetic Hsf1 deletion and a direct HSF1 small molecule inhibitor, we show that HSF1 is specifically required for the maintenance of AML, while sparing steady-state and stressed hematopoiesis. Mechanistically, deletion of Hsf1 dysregulates multifaceted genes involved in LSC stemness and suppresses mitochondrial oxidative phosphorylation through downregulation of succinate dehydrogenase C (SDHC), a direct HSF1 target. Forced expression of SDHC largely restores the Hsf1 ablation-induced AML developmental defect. Importantly, the growth and engraftment of human AML cells are suppressed by HSF1 inhibition. Our data provide a rationale for developing efficacious small molecules to specifically target HSF1 in AML.
Spatial snapshots of amyloid precursor protein intramembrane processing via early endosome proteomics
Authors: Park Hankum , Hundley Frances V. , Yu Qing , Overmyer Katherine A. , Brademan Dain R. , Serrano Lia , Paulo Joao A. , Paoli Julia C. , Swarup Sharan , Coon Joshua J. , Gygi Steven P. , Wade Harper J. 
Published: October 2022

AbstractDegradation and recycling of plasma membrane proteins occurs via the endolysosomal system, wherein endosomes bud into the cytosol from the plasma membrane and subsequently mature into degradative lysosomal compartments. While methods have been developed for rapid selective capture of lysosomes (Lyso-IP), analogous methods for isolation of early endosome intermediates are lacking. Here, we develop an approach for rapid isolation of early/sorting endosomes through affinity capture of the early endosome-associated protein EEA1 (Endo-IP) and provide proteomic and lipidomic snapshots of EEA1-positive endosomes in action. We identify recycling, regulatory and membrane fusion complexes, as well as candidate cargo, providing a proteomic landscape of early/sorting endosomes. To demonstrate the utility of the method, we combined Endo- and Lyso-IP with multiplexed targeted proteomics to provide a spatial digital snapshot of amyloid precursor protein (APP) processing by β and γ-Secretases, which produce amyloidogenic Aβ species, and quantify small molecule modulation of Secretase action on endosomes. We anticipate that the Endo-IP approach will facilitate systematic interrogation of processes that are coordinated on EEA1-positive endosomes.