bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacokinetics and tissue distribution of five bioactive components in the Corydalis yanhusuo total alkaloids transdermal patch following Shenque acupoint application in rats assessed by ultra‐performance liquid chromatography–tandem mass spectrometry
Authors: Wang Huinan , Wang Zhicheng , Jiang Mingrui , Yue Zhuzhu , Zhang Jingqiu , Chen Mengyu , Wang Menglin , Wei Xiaotong , Shi Shuanghui , Wang Yingzi 
Published: September 2022

AbstractThe purpose of this study was to evaluate the pharmacokinetics and tissue distribution of the Corydalis yanhusuo total alkaloids transdermal patch (CTTP) following Shenque acupoint application in rats. The concentrations of corydaline, tetrahydropalmatine, tetrahydrocolumbamine, protopine, and dehydrocorydaline in rat plasma and various tissues were simultaneously detected by ultra‐performance liquid chromatography–tandem mass spectrometry after Shenque acupoint administration of CTTP. Plasma, heart, liver, spleen, lung, and kidney tissue samples were collected at specific times and separated by gradient elution on an ACQUITY UPLC HSS T3 column (1.8 μm, 100 mm × 2.1 mm) with a mobile phase of 0.01% formic acid aqueous solution and acetonitrile–0.01% formic acid. The methodological results showed that the selectivity, linear range, accuracy, precision, stability, matrix effect, and extraction recovery of the established method met the requirements of biological sample analysis. The results indicated that CTTP following Shenque acupoint administration rapidly delivered adequate drug into rat blood and maintained an effective plasma level for a significantly longer time than non‐acupoint administration. Furthermore, CTTP effectively reached the liver through Shenque acupoint administration and showed tissue selectivity. The data obtained could provide a prospect for the treatment of chronic pain with CTTP following Shenque acupoint application.
Overall metabolic network analysis of urine in hyperlipidemic rats treated with Bidens bipinnata L.
Authors: Li Shu‐Jiao , Wang Yu‐Qing , Zhuang Guo , Jiang Xu , Shui Dong , Wang Xiao‐Yu 
Published: September 2022

AbstractHyperlipidemia has been highlighted as one of the most prominent and global chronic conditions nowadays. Bidens bipinnata L. (BBL), a folk medicine in contemporary China, has efficacy in the treatment of hyperlipidemia (HLP) in China. Although some physiological and pathological function parameters of hyperlipidemia have been investigated, little information about the changes in small metabolites in biofluids has been reported. In the present study, global metabolic profiling with high‐performance liquid chromatography–linear ion trap/Orbitrap high‐resolution mass spectrometry (HPLC–LTQ/Orbitrap MS) combined with a pattern recognition method was performed to discover the underlying lipid‐regulating mechanisms of BBL on hyperlipidemic rats induced by high‐fat diet (HFD). The total of four metabolites, up‐ or down‐regulated (p < 0.05 or 0.01), were identified and contributed to the progression of hyperlipidemia. These promising identified biomarkers underpin the metabolic pathway, including glyoxylate and dicarboxylate metabolism, the TCA cycle, sphingolipid metabolism and purine metabolism. They are disturbed in hyperlipidemic rats, and are identified using pathway analysis with MetPA. The altered metabolite indices could be regulated closer to normal levels after BBL intervention. The results demonstrated that urinary metabolomics is a powerful tool in the clinical diagnosis and treatment of hyperlipidemia to provide information on changes in metabolite pathways.
Influencing factors of stroke occurrence and recurrence in hypertensive patients: A prospective follow‐up studies
Authors: Jin Yuelong , Jiang Minmin , Pan Na , Chen Yan , Chang Weiwei , Zhu Lijun , Fang Zhengmei , Fei Shizao , Zhou Zixuan , Zhou Siyun , He Lianping , Yao Yingshui 
Published: September 2022

AbstractObjectiveTo understand the related risk factors of occurrence and recurrence of hypertension and provide scientific basis for relevant departments to better guide prevention and control work.MethodsFrom September 2017 to September 2018, a prospective follow‐up study was performed on patients with hypertension who visited the Second People's Hospital of Wuhu City, Anhui Province. Multivariate Cox regression was used to analyze influencing factors of stroke occurrence and recurrence in follow‐up of hypertensive patients.ResultsA total of 769 hypertensive patients were enrolled in this study. The average age of hypertensive patients was 65.66 ± 11.70 years old and the BMI index was 24.99 ± 4.17. In this study, 769 patients with hypertension were followed up for 1 year, and the incidence of stroke was 14.69%. This study found that higher levels of blood glucose (RR = 2.027, 95% CI: 1.195–3.438), HCY (RR = 5.928,95% CI: 1.438–24.440), aggravated extent of carotid artery stenosis (RR = 2.620, 95% CI: 1.532–4.481), and drinking (RR = 3.867, 95% CI: 2.038–7.339) were risk factors, and maintaining exercise (RR = 0.325, 95% CI: 0.117–0.907) was a protective factor for stroke occurrence; however, aggravated extent of carotid artery stenosis (RR = 3.158, 95% CI: 1.797–5.550) and smoking (RR = 2.271, 95% CI: 1.142–4.517) were risk factors for stroke recurrence for hypertensive patients.ConclusionsFor people with high blood pressure, it is necessary to exercise properly, control body weight, avoid obesity, quit smoking, reduce alcohol consumption, and reasonably control blood pressure, blood sugar, and blood lipid.
Comparative Study of Nano‐liposome and Nano‐niosome for Delivery ofAchillea MillefoliumEssential Oils: Development, Optimization, Characterization and Their Cytotoxicity Effects on Cancer Cell Lines and Antibacterial Activity
Authors: Emtiazi Hamideh , Salari Sharif Ali , Hemati Mahdie , Fatemeh Haghiralsadat Bibi , Pardakhti Abbas 
Published: September 2022

AbstractNanoencapsulation of essential oils (EOs) in drug delivery systems leads to their capability of improving their solubility, stability, and bioavailability of them. The aim of this study was preparation, optimization, and characterization of nano‐liposomes/nano‐niosomes containingAchillea millefoliumessential oils (A. millefoliumEOs) and comparison of their properties. In the experimental study, characteristics of nanoparticles including size, zeta potential, Fourier Transform Infrared Spectroscopy (FTIR), % encapsulation efficiency (EE%) and the release amount of essential oils from nano‐liposome or niosome were assessed using different techniques. Then to determine cell viability at different concentrations, the MTT assay was used. Also, the dilution method was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of antimicrobial agents. The optimized formulations provided potential advantages, including an appropriate nano‐size scale, and a negative charge, and also showed a continuous drug release behavior, which successfully encapsulated essential oil with high entrapment efficiency. In terms of size and release amount, nano‐niosome had superiority to nano‐liposome with smaller size and also slower release but nano‐liposome could encapsulate essential oils in a higher percentage compared to nano‐niosome. Also, there was a significant difference between the toxicity of encapsulated EOs and free EOs in terms of viability (P<0.05). In addition, the antimicrobial effect of liposomal and niosomal EO was greater than free EO. In conclusion, the designed nano‐based systems were determined as promising lipid‐based nano‐carriers for essential oil delivery that proffered a novel, high potential therapy for breast cancer and favorable antimicrobial effects.
Metformin encapsulated gold nanoparticles (MTF‐GNPs): A promising antiglycation agent
Authors: Alenazi Fahaad , Saleem Mohd , Khaja Azharuddin Sajid Syed , Zafar Mubashir , Alharbi Mohammed Salem , Hagbani Turki Al , Ashraf Jalaluddin Mohammad , Qamar Mohammad , Rafi Zeeshan , Ahmad Saheem 
Published: September 2022

AbstractThe generation of advanced glycation end products (AGEs) through nonenzymatic protein glycation contributes to the pathogenesis of long‐lived diabetic problems. Metformin (MTF) is the very first drug having antihyperglycemic effects on type II diabetes mellitus which also possess interaction with dicarbonyl compounds and blocks the formation of AGEs. In the current study, MTF is bioconjugated with glycation‐derived synthesized gold nanoparticles (GNPs) of significant size. Additionally, using various biophysical and biochemical approaches, we investigated the antiglycating capacity MTF‐GNPs in contrast to MTF against d‐ribose‐derived glycation of bovine serum albumin. Our key findings via utilizing various assays demonstrated that MTF‐GNPs were able to inhibit AGEs development by reducing hyperchromicity, early glycation products, carbonyl content, hydxoxymethylfurfural content, production of fluorescent AGEs, normalizing the loss of secondary structure (i.e., α‐helix and β‐sheets) of proteins, elevating the levels of free lysine and free arginine more efficiently compared to pure MTF. Based on these results, we concluded that MTF‐GNPs possess a considerable antiglycation property and may be developed as an outstanding anti‐AGEs treatment drug. Further in vivo and clinical research are necessary to determine the therapeutic effects of MTF‐GNPs against AGE‐related and metabolic disorders.
Benign or premalignant? Idiopathic granulomatous mastitis later diagnosed as ductal carcinoma breast cancer: Case report and review of literature
Authors: Zangouri Vahid , Niazkar Hamid Reza , Nasrollahi Hamid , Homapour Farhad , Ranjbar Aliyeh , Seyyedi Mahdiyeh Sadat 
Published: September 2022

AbstractIdiopathic granulomatous mastitis (IGM) is a rare benign infectious disease of the breast, commonly presenting with a unilateral breast mass. Since GM's clinical presentation and imaging can be very similar to breast cancer, diagnosing GM can be challenging. So far, various reports have demonstrated the probable correlation and co‐occurrence of granulomatous mastitis and breast cancer. This report presents a 38‐year‐old female with invasive ductal carcinoma, previously diagnosed as IGM.
Eumycotic mycetoma involving the right foot: A new Tunisian case
Authors: Ben Tekaya Aicha , Yosra Gzam , Saidane Olfa , Rouached Leila , Bouden Salma , Tekaya Raoudha , Mahmoud Ines , Abdelmoula Leila 
Published: September 2022

AbstractA Tunisian patient with painless swelling and discharging sinuses of the right foot was diagnosed with Eumycetoma after 1 year of evolution. Mycetoma is a neglected disease relatively rare in our country. An early and accurate diagnosis, based on histopathological and microbiological examinations, limits functional and esthetical damage.
Fatal invasive gastric mucormycosis: Two case reports
Authors: Khsiba Amal , Moalla Manel , Nechi Salwa , Bani Amina , Elloumi Aicha , Jemal Sana , Azouz Mohamed Moussaddek , Medhioub Mouna , Hamzaoui Lamine 
Published: September 2022

AbstractMucormycosis is a fungal infection affecting most commonly immunocompromised patients. Hereby, we report two cases: the first one is about a 61‐year‐old female with diabetes who presented with vomiting. The upper gastrointestinal endoscopy showed a budding grayish process which corresponded to an invasive mucormycosis in histology. As laboratory tests showed renal dysfunction, conventional amphotericin B was started at low doses since liposomal form was unavailable in Tunisia. Evolution was marked by a worsening of renal function leading to drug therapy withdrawal. Total gastrectomy was delayed because of a pulmonary embolism and was practiced 2 months later. The patient passed away 10 days after surgery. The second patient was a 59‐year‐old man who presented with vomiting and fast worsening of general state. At admission, he had a septic shock. Explorations revealed an invasive gastric mucormycosis. He died few days after admission. Thus, prompt diagnosis of mucormycosis and rapid initiation of treatment based on amphotericin B and surgical debridement is necessary to improve prognosis.
Untersuchung des Prozesses zum Unterwasserkleben von Halterungssystemen
Authors: Fröck Linda , Glück Nikolai , Flügge Wilko 
Published: September 2022

AbstractBetrieb und Wartung von Wasserbauwerken und ‐fahrzeugen erfordern häufig die nachträgliche Montage von Ausrüstungsgegenständen, wie Sensoren, Sonarsender oder Korrosionsschutzequipment unter Wasser. Durch Schweißen und oder mechanisches Fügen entstehen metallurgische/mechanische Kerben, weshalb im abgeschlossenen IGF‐Projekt „Unterwasserkleben“ ein geklebtes Haltersystem grundlegend entwickelt wurde. Ziel des Vorhabens „Unterwasserklebprozess“ ist die Untersuchung des Einflusses der Prozessparameter des mehrstufigen Injektionsprozesses (Medien, Zeiten, Drücke, etc.) auf die Verbindungsgüte und die Entwicklung eines entsprechenden teilautomatisierten Werkzeugs für den Einsatz durch Taucher oder ferngesteuerte Systeme.Investigation of the process of underwater bonding of holder systems. Operation and maintenance of waterway structures and vehicles often requires the subsequent installation of equipment such as sensors, sonar transmitters or corrosion protection equipment under water. Welding and or mechanical joining creates metallurgical/mechanical notches, which is why a glued holder system was fundamentally developed in the completed IGF project “Underwater Bonding”. The intent of the project “Underwater Bonding Process” is to investigate the influence of the process parameters of the multi‐stage injection process (media, times, pressures, etc.) on the bonding quality and the development of a corresponding semi‐automated tool for use by divers or remote operated vehicles.
Efficient Copper‐Catalyzed Highly Stereoselective Synthesis of Unprotected C‐Acyl Manno‐, Rhamno‐ and Lyxopyranosides
Authors: Boehlich Gordon Jacob , Sterzel Hannes , Rehbein Julia , Schützenmeister Nina 
Published: September 2022

AbstractDue to their high stability towards enzymatic hydrolysis C‐acyl glycosidic compounds are useful synthetic intermediates for potential candidates in drug discovery. Syntheses for C‐acyl mannosides have remained scarce and usually employ donors obtained from lengthy syntheses. Furthermore, syntheses of unprotected C‐acyl mannosides have not been reported so far, due to the incapability of the C‐acyl mannoside motif with deprotection conditions for protective groups commonly used in carbohydrate chemistry. Herein, we report an efficient and highly α‐selective four‐step one‐pot method for the synthesis of C‐acyl α‐d‐manno‐, l‐rhamno‐ and d‐lyxopyranosides from easily accessible persilylated monosaccharides and dithianes requiring only trace amounts of a copper source as catalyst and explain the crucial role of the catalyst by mechanistic studies. Furthermore, the C‐acyl α‐glycosides were easily isomerized to give rapid access to their β‐anomers.
A structured reflection for improving third party interventions and mediation practice: Reconsidering debrief
Authors: Peleg‐Baker Tzofnat , Lang Michael 
Published: September 2022

AbstractWe make a case for structured reflective practice for improving third‐party interventions and mediation decision‐making and outcomes. We propose that a lack of awareness of the automatic, intuitive nature of judgments that dominate the fast‐paced and uncertain mediation circumstances risk a proper treatment of implicit social‐psychological matters driving conflict and suitably addressing substantive issues. Implicit matters include parties' feelings about themselves and relational and process‐related issues. The quality of intuitive unconscious decisions could improve by conscious structured reflective practice. This reflection presents a learning opportunity to gain an awareness of unconscious judgments and advance a beneficial interplay between conscious and unconscious processing. To support the significance of conscious, reflective practice for improving automated decisions in third‐party interventions and mediation, we present the context of mediation and findings on cognitive processing, intuitive decision‐making, expertise, and reflective practice. Empirical findings in negotiation, management, and medicine confirm the effectiveness of structured reflective practice. A research‐based, four‐dimensional Structured Reflective Instrument (SRI) developed by Tzofnat Peleg‐Baker is offered. It was designed to systematically help mediators improve judgments, particularly the response to implicit mediation goals and outcomes. We provide an example of one dimension of the SRI in the Appendix.
Urinary excretion patterns and potential risks of beta‐blocker ophthalmic drops in sports
Authors: Lin Yi‐An , Chiang Wei‐Yu , Chang William Chih‐Wei , Kuo Ming‐Tse , Chen Alexander , Hsu Mei‐Chich 
Published: September 2022

AbstractBeta‐blockers have been prohibited by the World Anti‐Doping Agency (WADA) in certain sports, but insufficient research data make it difficult to distinguish between therapeutic uses or misuses. This study aimed at investigating the urinary excretion pattern following beta‐blocker ophthalmic drops and the potential risk of constituting an adverse analytical finding (AAF) in sports. Prescribed timolol and carteolol ophthalmic drops were used in healthy participants and glaucoma patients. The urine samples were then collected to investigate the urinary excretion pattern following acute and chronic administration of the above beta‐blocker ophthalmic drops. The liquid chromatograph‐tandem mass spectrometry method was applied for measuring urinary beta‐blockers. Our results demonstrated that the levels of both urinary timolol and carteolol exceeded the minimum reporting levels (MRL) following acute and chronic administration. The highest levels of urinary timolol and carteolol observed in the present study were 255.7 and 923.8 ng/ml, respectively. Regarding the acute administration of timolol ophthalmic drop, 26.19 (11/42) of urine samples were detected with timolol higher than the MRL in timed and random sampling. In contrast, the acute administration of carteolol ophthalmic drops made the carteolol levels higher than the MRL among most urine samples. On the other hand, 36.36% (4/11) of urine samples were detected with beta‐blockers higher than the MRL during the chronic administration of timolol and carteolol ophthalmic drops. In the context of receiving ophthalmic beta‐blocker medications, the present study has highlighted the potential risk of constituting an AAF in specific sports and suggests strengthening athletes' awareness of therapeutic use exemptions.
Association of immune cell subsets with incident heart failure in two population‐based cohorts
Authors: Sinha Arjun , Sitlani Colleen M. , Doyle Margaret F. , Fohner Alison E. , Buzkova Petra , Floyd James S. , Huber Sally A. , Olson Nels C. , Njoroge Joyce N. , Kizer Jorge R. , Delaney Joseph A. , Shah Sanjiv S. , Tracy Russell P. , Psaty Bruce , Feinstein Matthew 
Published: September 2022

AbstractAimsCirculating inflammatory markers are associated with incident heart failure (HF), but prospective data on associations of immune cell subsets with incident HF are lacking. We determined the associations of immune cell subsets with incident HF as well as HF subtypes [with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF)].Methods and resultsPeripheral blood immune cell subsets were measured in adults from the Multi‐Ethnic Study of Atherosclerosis (MESA) and Cardiovascular Health Study (CHS). Cox proportional hazard models adjusted for demographics, HF risk factors, and cytomegalovirus serostatus were used to evaluate the association of the immune cell subsets with incident HF. The average age of the MESA cohort at the time of immune cell measurements was 63.0 ± 10.4 years with 51% women, and in the CHS cohort, it was 79.6 ± 4.4 years with 62% women. In the meta‐analysis of CHS and MESA, a higher proportion of CD4+ T helper (Th) 1 cells (per one standard deviation) was associated with a lower risk of incident HF [hazard ratio (HR) 0.91, (95% CI 0.83–0.99), P = 0.03]. Specifically, higher proportion of CD4+ Th1 cells was significantly associated with a lower risk of HFrEF [HR 0.73, (95% CI 0.62–0.85), <0.001] after correction for multiple testing. No association was observed with HFpEF. No other cell subsets were associated with incident HF.ConclusionsWe observed that higher proportions of CD4+ Th1 cells were associated with a lower risk of incident HFrEF in two distinct population‐based cohorts, with similar effect sizes in both cohorts demonstrating replicability. Although unexpected, the consistency of this finding across cohorts merits further investigation.
A prospective study on myocardial injury after BNT162b2 mRNA COVID‐19 fourth dose vaccination in healthy persons
Authors: Levi Nir , Moravsky Gil , Weitsman Tatyana , Amsalem Itshak , Bar‐Sheshet Itach Sarit , Algur Nurit , Lapidus Ira , Mitz Ofir , Glikson Michael , Wiener‐Well Yonit , Hasin Tal 
Published: September 2022

AimsTo prospectively evaluate the incidence of myocardial injury after the administration of the fourth dose BNT162b2 mRNA vaccine (Pfizer‐BioNTech) against COVID‐19.Methods and resultsHealth care workers who received the BNT162b2 vaccine during the fourth dose campaign had blood samples collected for high‐sensitivity cardiac troponin (hs‐cTn) during vaccine administration and 2–4 days afterward. Vaccine‐related myocardial injury was defined as hs‐cTn elevation above the 99th percentile upper reference limit and >50% increase from baseline measurement. Participants with evidence of myocardial injury underwent assessment for possible myocarditis. Of 324 participants, 192 (59.2%) were female and the mean age was 51.8 ± 15.0 years. Twenty‐one (6.5%) participants had prior COVID‐19 infection, the mean number of prior vaccine doses was 2.9 ± 0.4, and the median time from the last dose was 147 (142–157) days. Reported vaccine‐related adverse reactions included local pain at injection site in 57 (17.59%), fatigue in 39 (12.04%), myalgia in 32 (9.88%), sore throat in 21 (6.48%), headache in 18 (5.5%), fever ≥38°C in 16 (4.94%), chest pain in 12 (3.7%), palpitations in 7 (2.16%), and shortness of breath in one (0.3%) participant. Vaccine‐related myocardial injury was demonstrated in two (0.62%) participants, one had mild symptoms and one was asymptomatic; both had a normal electrocardiogram and echocardiography.ConclusionIn a prospective investigation, an increase in serum troponin levels was documented among 0.62% of healthy health care workers receiving the fourth dose BNT162b2 vaccine. The two cases had mild or no symptoms and no clinical sequela.Clinical Trial Registration:
ClinicalTrials.gov Identifier: NCT05308680.