bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term results in three‐dimensional, complex bone augmentation procedures with customized titanium meshes
Authors: Hartmann Amely , Hildebrandt Helmut , Younan Zina , Al‐Nawas Bilal , Kämmerer Peer W. 
Published: September 2022

AbstractObjectivesComplex, three‐dimensional bony defects still represent challenging situations in routine implant dentistry. The aim of this study was to evaluate implant survival in customized bone regeneration using a patient‐specific titanium mesh.Material and MethodsPatients (n = 21, implants 36) who had obtained an augmentation procedure with patient‐specific titanium mesh were examined after 5.7 ± 0.38 years. Survival rate, clinical parameters for periimplantitis (Bleeding on Probing [BOP] and suppuration), and radiographic examination were evaluated. Peri‐implant marginal bone loss (MBL) was calculated by using an image assessment program. Additionally, the influence of various factors on treatment outcomes such as periodontitis, smoking, professional maintenance, or diabetes was assessed as well as the impact on quality of life applying the Oral Health Impact Profile (OHIP).ResultsThe implant survival rate was 97%, with one implant loss in the lower jaw. At the end of the observation period, MBL showed mesial 0.13 ± 1.84 mm and distal −0.13 ± 1.73 mm. The lower jaw showed significant more MBL mesial compared with the upper jaw (p = .034, cluster‐adjusted). Periodontitis was significantly associated with MBL mesial and distal (p < .05). Positive BOP (four implants) was significantly associated with MBL mesial (p = .0031) and distal (p = .0018). MBL was significantly associated with suppuration mesial (p < .0001) and distal (p < .0001).ConclusionsCBR® results in high implant survival rate and stabilized augmented marginal bone after follow‐up of minimum 5 years. Periodontitis seems to play the mayor role for long‐term stability indicated by BOP and suppuration.
Optimizing habitat connectivity among macaque populations in modern Japan
Authors: Enari Hiroto , Seino Hironori , Uno Takeharu , Morimitsu Yoshiki , Takiguchi Masaaki , Suzuki Katsuya , Tsuji Yamato , Yamabata Naoto , Kiyono Mieko , Akaza Hisaaki , Izumiyama Shigeyuki , Oi Toru , Ebihara Hiroshi , Miki Kiyomasa , Kuramoto Musashi , Enari Haruka S. 
Published: September 2022

AbstractNationwide depopulation in modern Japan has led to contrasting changes over the last half‐century: shrinking human communities and recovering populations of Japanese macaques (Macaca fuscata). These changes have triggered macaque damage to public livelihoods, often resulting in decision‐making directed toward strictly regulating macaque populations. To optimize conservation interventions required today, we aimed to identify macaque habitats with conservation priorities to enhance population connectivity. To quantify the current population connectivity, we conducted a least‐cost path analysis by assigning an inverse of habitat suitability as resistance. For this, we collected geo‐information on home ranges of 2288 troops, accounting for >70% of the total number of troops in Japan. Moreover, we composed a minimum spanning tree using least‐cost paths to provide optimal population connectivity. Consequently, the modeled resistance showed that, although human‐induced barriers (i.e., flat areas where people frequently reside) and geographical barriers (i.e., alpine regions >1500 m above sea level) had the highest dispersal cost, macaques presented a high plasticity in the occupation of different forest types. The minimum spanning tree, composed of 77 modeled corridors, detected the vulnerability of population connectivity in western Japan and assigned conservation priorities to these isolated populations to preserve the stepping‐stone paths of macaque movement.
Putting out the welcome mat—A qualitative exploration of service delivery processes and procedures as barriers to treatment‐seeking for people who use alcohol and other drugs
Authors: Francia Leanne , Lam Tina , Berg Amelia , Morgan Kirsty , Savic Michael , Lubman Dan I. , Nielsen Suzanne 
Published: September 2022

AbstractIntroductionThere are a range of models and structures that determine features of alcohol and other drug treatment. Despite some structures being long‐established, less is known about how specific aspects of service delivery impact treatment‐seeking for people who use alcohol and other drugs. This Australian qualitative study explored both people with lived experience of problematic alcohol and other drug use, and health care staff's experiences of service delivery.MethodsThirty‐nine semi‐structured interviews with people with lived experience and staff from either alcohol and other drug specialist, or broader health‐care services, explored experiences of service delivery processes and procedures. Transcripts were thematically analysed and guided by a broad interest in barriers to treatment‐seeking.ResultsWithin alcohol and other drug specialist services (i) time spent on wait lists; and (ii) poor implementation of assessment processes were identified barriers to treatment‐seeking and engagement. Within broader health‐care services (i) organisational expectations around behaviour and engagement; (ii) alcohol and other drugs viewed as separate to service role; and (iii) limited opportunities to informally engage were identified barriers to treatment‐seeking.Discussion and ConclusionsResults suggest opportunities to engage and undertake needs‐based care planning are yet to be fully realised, particularly at the intake and assessment stages of alcohol and other drug service delivery; with frequent reassessment resulting in people repeatedly recounting traumatic experiences, often to different people, only to be placed back on wait lists with no support. Within broader health‐care services aspects of service delivery may perpetuate stigma that places such people outside the purview of health care.
Plasminogen activating inhibitor‐1 promotes angiogenesis in cutaneous angiosarcomas
Authors: Ohuchi Kentaro , Amagai Ryo , Ikawa Tetsuya , Muto Yusuke , Roh Yuna , Endo Junko , Maekawa Takeo , Kambayashi Yumi , Asano Yoshihide , Fujimura Taku 
Published: September 2022

AbstractPlasminogen activating inhibitor‐1 (PAI‐1) is associated with poor clinical outcomes, and elevated levels of PAI‐1 in both tissue and serum are correlated with poor response to therapy in various cancers, including skin cancer. Cutaneous angiosarcoma (CAS) is a vascular tumor histologically characterized by detachment of endothelial cell‐derived tumor cells. Since CAS expresses multiple angiogenic growth factors and has increased expressions of angiogenic receptor tyrosine kinase transcripts including VEGFR1/2/3, angiogenesis‐promoting factors are potential drug targets in CAS. In this study, the expression of PAI‐1 was examined in 31 cases of CAS, and the immunomodulatory effects of PAI‐1 on a human CAS cell line, ISO‐HAS‐B, were evaluated. We found that, of the angiogenesis‐promoting factors, PAI‐1 was expressed in almost all cases of CAS, and PAI‐1 increased the mRNA expressions of IL‐23p19, VEGF‐C, CXCL5 and CCL20 on ISO‐HAS‐B. Moreover, PAI‐1 stimulated ISO‐HAS‐B culture supernatant promoted favourable tube networks, suggesting that these tumor‐derived factors promote the pro‐angiogenic effect on tumor development. In addition, IL‐23p19 was expressed in 61.3% of cases, whereas VEGF‐C was expressed in 41% of cases. The results of the present study suggest that PAI‐1 promotes angiogenesis that results in tumor progression in CAS.
Job offers recommender system based on virtual organizations
Authors: González‐Briones Alfonso , Chamoso Pablo , Pavón Juan , De La Prieta Fernando , Corchado Juan M. 
Published: September 2022

AbstractHuman interaction has changed considerably with the emergence of the Internet. Today, a large percentage of daily communication takes place on instant messaging applications and social networks. In fact, there has been a considerable increase in the use of social networks because new social networks are being created for specific purposes, such as the search for employment or tourism. When the amount of content on a social network is large, it is necessary to help users find content of their interest. In this regard, artificial intelligence techniques can greatly facilitate the task of searching for relevant content. This paper presents a recommender system for a business and employment oriented social network, on which users are recommended job offers and other user profiles to follow. The presented system is based on virtual organizations of agents, and uses artificial neural networks to determine whether job offers and users should be recommended or not. The system has been evaluated on a real social network; its recommendations regarding job offers and user profiles have had a high acceptance rate.
Biodiversity patterns diverge along geographic temperature gradients
Authors: Loewen Charlie J. G. , Jackson Donald A. , Gilbert Benjamin 
Published: September 2022

AbstractModels applying space‐for‐time substitution, including those projecting ecological responses to climate change, generally assume an elevational and latitudinal equivalence that is rarely tested. However, a mismatch may lead to different capacities for providing climatic refuge to dispersing species. We compiled community data on zooplankton, ectothermic animals that form the consumer basis of most aquatic food webs, from over 1200 mountain lakes and ponds across western North America to assess biodiversity along geographic temperature gradients spanning nearly 3750 m elevation and 30° latitude. Species richness, phylogenetic relationships, and functional diversity all showed contrasting responses across gradients, with richness metrics plateauing at low elevations but exhibiting intermediate latitudinal maxima. The nonmonotonic/hump‐shaped diversity trends with latitude emerged from geographic interactions, including weaker latitudinal relationships at higher elevations (i.e. in alpine lakes) linked to different underlying drivers. Here, divergent patterns of phylogenetic and functional trait dispersion indicate shifting roles of environmental filters and limiting similarity in the assembly of communities with increasing elevation and latitude. We further tested whether gradients showed common responses to warmer temperatures and found that mean annual (but not seasonal) temperatures predicted elevational richness patterns but failed to capture consistent trends with latitude, meaning that predictions of how climate change will influence diversity also differ between gradients. Contrasting responses to elevation‐ and latitude‐driven warming suggest different limits on climatic refugia and likely greater barriers to northward range expansion.
Advancing disaster geographies: From marginalisation to inclusion of gender and sexual minorities
Authors: Haworth Billy Tusker , McKinnon Scott , Eriksen Christine 
Published: September 2022

AbstractDespite growing awareness and research into experiences of gender and sexual minorities – also known as lesbian, gay, bisexual, trans, queer, intersex, asexual and other identities (LGBTQIA+) – their needs and capacities are often overlooked in crisis response and disaster risk reduction. LGBTQIA+ peoples' vulnerability is shaped by social marginalisation, discrimination, and stigma, and exacerbated by dominant value systems and Western heteronormative framings of disaster experiences. We present a review of scholarship into gender and sexual minorities and disasters. We summarise extant knowledge and identify areas for growth in the field of disaster geographies. We argue that progress requires increased conceptual and methodological focus on diversity and the intersectional factors that exacerbate marginality, more inclusive knowledge production pathways focussed on risk reduction, and establishing methods for LGBTQIA+ people to be involved in research about them. More critical and inclusive research will not only aid progress in disaster geographies; it will also provide vital evidence with which to lobby policymakers and disaster management to pay closer attention to diversity and inclusion. By moving beyond normativity, cisgender‐heterosexual assumptions, and homogenising identity labels, we can begin to address social, cultural, and political factors that determine spatial inequalities, marginalisation, and disaster vulnerability for gender and sexual minorities.
Association of pharmacotherapy with the second hip fracture incidence in women: A retrospective analysis of the National Database of Health Insurance Claims and Specific Health Checkups of Japan
Authors: Nakatoh Shinichi , Fujimori Kenji , Ishii Shigeyuki , Tamaki Junko , Okimoto Nobukazu , Ogawa Sumito , Iki Masayuki 
Published: September 2022

AimSecond hip fractures worsen the quality of life and are associated with increased mortality. We clarified the association between the pharmacotherapy and second hip fracture prevention.MethodsThe relationship between the incidence of second hip fracture and the presence, type and medication possession ratio (MPR) of pharmacotherapy was investigated using medical insurance data from the National Database of Health Insurance Claims and Specific Health Checkups of Japan during April 2012 to March 2019.ResultsData of 776 040 female patients were analyzed. The 2‐year rate of second hip fractures was 3.31% (n = 25 684). Bisphosphonates (n = 148 138, 19.1%) were the most commonly used medications after primary hip fracture. Patients receiving selective estrogen receptor modulators (SERMs) had the lowest age, followed by those receiving bisphosphonates, denosumab and parathyroid hormone (PTH). The second hip fracture crude incidence was lowest in patients administered SERMs (n = 859, 2.44%), followed by those administered bisphosphonates (n = 4451, 3.00%), denosumab (n = 484, 3.19%), no medication (n = 19 017, 3.39%) and PTH (n = 873, 5.35%); however, the age‐adjusted incidence was the lowest in patients administered denosumab (2.22%), followed by those administered bisphosphonates (2.35%), SERMs (2.39%), no medications (3.39%) and PTH (3.67%). The MPR was highest in patients administered denosumab (60.0%). Among patients without a second hip fracture, the rate of patients with MPR ≥80% was highest among those administered SERMs (40.8%), followed by those administered bisphosphonates (38.0%), denosumab (35.4%) and PTH (12.2%).ConclusionDifferences in patient background characteristics and the rate of patients with MPR ≥80% might underlie the observed differences in the crude incidence of second hip fracture among the medication groups. Geriatr Gerontol Int 2022; 22: 930–937.
The law and politics of transnational rights protection: Trusteeship, effectiveness, de‐delegation
Authors: Stone Sweet Alec , Sandholtz Wayne 
Published: September 2022

AbstractInternational trustee courts embody a specific form of delegation, in which state principals confer on such courts the authority to interpret and apply treaties agreed by the states in order to realize specific values and interests. Human rights courts help states resolve commitment and enforcement problems that are inherent in human rights treaties. This study seeks to answer the question, what happens when states parties seek to reduce or eliminate the authority of a human rights court? To answer these questions, the article assesses six human rights treaty regimes: the Council of Europe; the Organization of American States; the African Union; the Economic Community of West African States; the East African Community; and the Southern African Development Community. The article identifies four types of de‐delegation possible with respect to international human rights courts and assesses the extent to which states have sought to de‐delegate from them. With one exception (the SADC Tribunal), the regimes examined here have so far successfully withstood the challenge of de‐delegation.
Defective structure of doped carbons obtained from preceramic polymers through Cl2‐ and NH3‐assisted thermolysis
Authors: Pérez Berta , Rubio Fausto , Rubio Juan , Tamayo Aitana 
Published: September 2022

AbstractThe processing parameters such as the heat treatment temperature, type of preceramic precursor, and post‐synthesis treatments are key factors for the development the different microstructures in polymer‐derived ceramics. Moreover, doping with different heteroatoms has increased the ability of the polymer‐derived ceramics to produce tunable nanostructures with a controlled pore size and distributions. A preceramic precursor containing P has been prepared from a commercial polysiloxane polymer and a phosphate alkoxide. It has been subjected to thermal treatments in N2, NH3, and Cl2 atmospheres in different order sequences to create differentiated microstructures either in the ceramic matrix and the carbon phase. The structural, textural, and spectroscopic characterization revealed that the P atoms play a key role in the evolution of the microstructure during the thermal treatments. If the chlorination is carried out before the treatment in NH3, a silicophosphate matrix is formed and prevents from nitrogen incorporation into the free carbon phase. On contrary, if the NH3 treatment is carried out before the chlorination, the carbon phase is predominantly modified by the incorporation of P atoms within the free carbon network.
Combined atrial fibrillation ablation and balloon mitral commissurotomy in patients with rheumatic mitral stenosis
Authors: Díez‐Delhoyo Felipe , Sánchez De La Nava Ana María , Sanz‐Ruiz Ricardo , Ávila Pablo , González‐Torrecilla Esteban , Delgado‐Montero Antonia , López Jairo , Bermejo Javier , Arenal Ángel , Atienza Felipe , Fernández‐Avilés Francisco 
Published: September 2022

AbstractIntroductionAblation of atrial fibrillation (AF) is usually not considered in patients with rheumatic mitral stenosis (RMS). We analyzed the results of a combined procedure of AF ablation and percutaneous balloon mitral commissurotomy (PBMC).MethodsWe prospectively included 22 patients with severe RMS to undergo a combined PBMC + AF ablation procedure. Noninvasive mapping of the atria was also performed. A historical sample of propensity‐scored matched patients who underwent PBMC alone was used as controls. The primary endpoint was freedom from AF/AT at 1‐year. Multivariate analysis evaluated sinus rhythm (SR) predictors.ResultsSuccessful pulmonary vein isolation and electrocardiographic imaging‐based drivers ablation was performed in 20 patients following PBMC. At 1‐year, 75% of the patients in the combined group were in SR compared to 40% in the propensity‐score matched group (p = 0.004). The composite of AF recurrence, need for mitral surgery and all‐cause mortality was also more frequent in the control group (65% vs. 30%; p = 0.005). Catheter ablation (odds ratio [OR] 1.58; 95% confidence interval [CI] [1.17–17.37]; p = 0.04) and AF type (OR 1.46; 95% CI [1.05–82.64]; p < 0.001) were the only independent predictors of SR at 1‐year. Noninvasive mapping in the combined group showed that the number of simultaneous rotors (OR 2.10; 95% CI [1.41–10.2]; p = 0.04) was the only independent predictor of AF.ConclusionA combined procedure of AF ablation and PBMC significantly increased the proportion of patients in sinus rhythm at 1‐year. Noninvasive mapping may help to improve AF characterization and guide personalized AF treatment.
The effects of systemic immunomodulatory treatments on COVID‐19 outcomes in patients with atopic dermatitis: Results from the global SECURE‐AD registry
Authors: Musters Annelie H. , Broderick Conor , Prieto‐Merino David , Chiricozzi Andrea , Damiani Giovanni , Peris Ketty , Dhar Sandipan , De Abhishek , Freeman Esther , Arents Bernd W. M. , Burton Tim , Bosma Angela Leigh‐Ann L. , Chi Ching‐Chi , Fletcher Godfrey , Drucker Aaron M. , Kabashima Kenji , de Monchy Emilie F. , Panda Maitreyee , Wall Dmitri Robert , Vestergaard Christian , Mahé Emmanuel , Bonzano Laura , Kattach Leila , Napolitano Maddalena , Ordoñez‐Rubiano María Fernanda , Haufe Eva , Patruno Cataldo , Irvine Alan D. , Spuls Phyllis I. , Flohr Carsten 
Published: September 2022

AbstractBackgroundLimited data are available on the effects of systemic immunomodulatory treatments on COVID‐19 outcomes in patients with atopic dermatitis (AD).ObjectiveTo investigate COVID‐19 outcomes in patients with AD treated with or without systemic immunomodulatory treatments, using a global registry platform.MethodsClinicians were encouraged to report cases of COVID‐19 in their patients with AD in the Surveillance Epidemiology of Coronavirus Under Research Exclusion for Atopic Dermatitis (SECURE‐AD) registry. Data entered from 1 April 2020 to 31 October 2021 were analysed using multivariable logistic regression. The primary outcome was hospitalization from COVID‐19, according to AD treatment groups.Results442 AD patients (mean age 35.9 years, 51.8% male) from 27 countries with strongly suspected or confirmed COVID‐19 were included in analyses. 428 (96.8%) patients were treated with a single systemic therapy (n = 297 [67.2%]) or topical therapy only (n = 131 [29.6%]). Most patients treated with systemic therapies received dupilumab (n = 216). Fourteen patients (3.2%) received a combination of systemic therapies. Twenty‐six patients (5.9%) were hospitalized. No deaths were reported. Patients treated with topical treatments had significantly higher odds of hospitalization, compared with those treated with dupilumab monotherapy (odds ratio (OR) 4.65 [95%CI 1.71–14.78]), including after adjustment for confounding variables (adjusted OR (aOR) 4.99 [95%CI 1.4–20.84]). Combination systemic therapy which did not include systemic corticosteroids was associated with increased odds of hospitalization, compared with single agent non‐steroidal immunosuppressive systemic treatment (OR 8.09 [95%CI 0.4–59.96], aOR 37.57 [95%CI 1.05–871.11]). Hospitalization was most likely in patients treated with combination systemic therapy which included systemic corticosteroids (OR 40.43 [95%CI 8.16–207.49], aOR 45.75 [95%CI 4.54–616.22]).ConclusionsOverall, the risk of COVID‐19 complications appears low in patients with AD, even when treated with systemic immunomodulatory agents. Dupilumab monotherapy was associated with lower hospitalization than other therapies. Combination systemic treatment, particularly combinations including systemic corticosteroids, was associated with the highest risk of severe COVID‐19.
Effect of surface prereacted glass ionomer nanofillers on fluoride release, flexural strength, and surface characteristics of polymethylmethacrylate resin
Authors: Jitaluk Poomchai , Ratanakupt Kwanchanok , Kiatsirirote Kritirat 
Published: September 2022

AbstractObjectiveDentures should have proper fluoride release and physical properties. We evaluated how surface prereacted glass ionomer (S‐PRG) nanofillers influenced fluoride release, flexural strength, and surface characteristics of polymethylmethacrylate (PMMA) resin.Materials and MethodsPMMA resin disc (n = 14) and rectangular (n = 5) specimens containing 0, 20 wt% microparticles, and 20 wt% nanoparticles of S‐PRG were prepared. Six‐disc specimens were examined for surface roughness; eight‐disc specimens were immersed in 5 ml of deionized water for 24 h before analyzing the fluoride levels on days 1–3, 12, and 15. They were recharged with 1000 ppm fluoride solution for 24 h and stored in deionized water for five cycles. Fluoride release was examined. The flexural strength of the rectangular specimens was determined using a three‐point bending test. Data were analyzed by two‐way repeated‐measures ANOVA.ResultsS‐PRG nanofiller had the highest fluoride exchange rate and did not significantly change the surface roughness compared with the microparticle and control groups; however, the nanofillers agglomerated and reduced the flexural strength to below 65 MPa.ConclusionsIncorporating 20 wt% nanofillers into resin enhanced the fluoride exchange property greater than microfillers at the same content, but diminished the mechanical properties of the resin.Clinical SignificanceIncorporating 20 wt% S‐PRG nanofillers in resin denture base can improve the fluoride releasing property without affecting the surface roughness.