bluuebunny/crossref_metadata_2025_split huggingface dataset:
Membrane‐type 1 matrix metalloproteinase as predictor of survival and candidate therapeutic target in Ewing sarcoma
Authors: Brookes Marcus J. , Roundhill Elizabeth A. , Jeys Lee , Parry Michael , Burchill Susan A. , Rankin Kenneth S. 
Published: September 2022

AbstractBackgroundEwing sarcoma (ES) is the second most common primary bone malignancy, with an urgent need for new treatments. ES is associated with high rates of progression and relapse, driven by drug‐resistant cells capable of migration, self‐renewal and single‐cell tumorigenesis, termed cancer stem‐like cells (CSCs). Membrane‐type 1 matrix metalloproteinase (MT1‐MMP) is a membrane‐bound proteolytic enzyme, which, via direct and indirect mechanisms, digests four of the main types of collagen. This can be hijacked in malignancy for invasion and metastasis, with high expression predicting decreased survival in multiple cancers. In this study, we have examined the hypothesis that MT1‐MMP is expressed by ES cells and explored the relationship between expression and outcomes.ProcedureMT1‐MMP expression in ES established cell lines, primary patient‐derived cultures and daughter ES‐CSCs was characterised by RNA sequencing, Western blotting, immunocytochemistry and flow cytometry. Immunohistochemistry was used to detect MT1‐MMP in tumour biopsies, and the relationship between expression, event‐free and overall survival examined.ResultsMT1‐MMP was detected at both RNA and protein levels in five of six established cell lines, all primary cultures (n = 25) and all daughter ES‐CSCs (n = 7). Immunohistochemistry of treatment‐naïve biopsy tissue demonstrated that high MT1‐MMP expression predicted decreased event‐free and overall survival (p = .017 and .036, respectively; n = 47); this was not significant in multivariate analysis.ConclusionsMT1‐MMP is expressed by ES cells, including ES‐CSCs, making it a candidate therapeutic target. The level of MT1‐MMP expression at diagnosis may be considered as a prognostic biomarker if validated by retrospective analysis of a larger cohort of clinical trial samples.
Recent progress of elastomer–silica nanocomposites toward green tires: simulation and experiment
Authors: Li Xiu , Liu Jun , Zheng Zi‐Jian 
Published: September 2022

AbstractThe concern regarding increasing oil consumption that originates from the high rolling resistance of automobiles has led to the development of green tires. The key enabling technique for preparing green tires involves the utilization of elastomer–silica nanocomposites. Elastomer–silica nanocomposites usually show low rolling resistance because of the intrinsic lubrication characteristics of siloxane and the excellent elastomer‐modified silica interfacial interaction, making them ideal raw materials for a green tire. It is supposed that the comprehensive properties of rolling resistance can be further improved via continually optimizing the microstructures of elastomer–silica nanocomposites. Regulating silica dispersion, understanding the interface between elastomer and silica and building the quantitative correlation between the microstructure and the static/dynamic macro‐mechanical properties are crucial in designing high‐performance elastomer–silica nanocomposites. This review aims to summarize the recent progress of elastomer–silica nanocomposites from the point of view of silica dispersion, the elastomer–silica interface and the microstructure–mechanical connection, combining simulation and actual experimental findings. A short conclusion and an outlook on the current limitations and possible future research directions for constructing high‐performance elastomer–silica nanocomposites for low‐energy green tires are also presented. © 2022 Society of Industrial Chemistry.
Investigation of structural and optical properties of ternary polyaniline–polypyrrole–nickel oxide (PANI‐PPy‐NiO) nanocomposite for optoelectronic devices
Authors: Elumalai Priyanka , Charles Julie 
Published: September 2022

AbstractA new ternary nanocomposite comprising nickel oxide (NiO) embedded into a binary polymeric network of polyaniline (PANI) and polypyrrole (PPy), i.e. PANI‐PPy‐NiO, is synthesized using an in situ chemical oxidative method. The infrared spectrum of PANI‐PPy‐NiO exhibits most of the characteristic peaks of unary nanoparticles with slight shift in the frequencies. The shift is due to the synergistic interaction of binary PANI‐PPy with the inorganic NiO nanoparticles. X‐ray diffraction pattern reveals the semicrystalline structure of the PANI‐PPy‐NiO nanocomposite with an average crystallite size of 22 nm. From Williamson–Hall plot, the micro‐strain value of as‐prepared PANI‐PPy‐NiO is found to be −0.16727. Surface morphology of PANI‐PPy‐NiO shows fine grains of NiO‐encapsulated PANI‐PPy that tend to coalesce and form an agglomeration assembly. The elements detected from energy‐dispersive X‐ray analysis indicate the purity of synthesis of the ternary material. Further, the optical constants obtained from UV–visible spectra (absorption coefficient, extinction coefficient, refractive index, optical conductivity and real and imaginary dielectric constants) are found to be higher for PANI‐PPy‐NiO than for the unary PANI, PPy and NiO nanoparticles. Tauc plot and Urbach energy studies indicate the low bandgap energy of PANI‐PPy‐NiO (2.67 eV) compared to unary nanoparticles. Further, the emission intensity peak (492 nm) observed in the photoluminescence spectrum of PANI‐PPy‐NiO corresponds to the blue region of the visible spectrum. Thus, the optical studies clearly indicate the high suitability of the synthesized PANI‐PPy‐NiO in visible‐light‐based device applications. © 2022 Society of Industrial Chemistry.
Recent advances in demystifying O‐glycosylation in health and disease
Authors: Li Jiajia , Guo Bo , Zhang Wenqi , Yue Shuang , Huang Shan , Gao Song , Ma Junfeng , Cipollo John F. , Yang Shuang 
Published: September 2022

AbstractO‐Glycosylation is one of the most common protein post‐translational modifications (PTM) and plays an essential role in the pathophysiology of diseases. However, the complexity of O‐glycosylation and the lack of specific enzymes for the processing of O‐glycans and their O‐glycopeptides make O‐glycosylation analysis challenging. Recently, research on O‐glycosylation has received attention owing to technological innovation and emerging O‐glycoproteases. Several serine/threonine endoproteases have been found to specifically cleave O‐glycosylated serine or threonine, allowing for the systematic analysis of O‐glycoproteins. In this review, we first assessed the field of protein O‐glycosylation over the past decade and used bibliometric analysis to identify keywords and emerging trends. We then summarized recent advances in O‐glycosylation, covering several aspects: O‐glycan release, site‐specific elucidation of intact O‐glycopeptides, identification of O‐glycosites, characterization of different O‐glycoproteases, mass spectrometry (MS) fragmentation methods for site‐specific O‐glycosylation assignment, and O‐glycosylation data analysis. Finally, the role of O‐glycosylation in health and disease was discussed.
Governing social eating (chibo) influencers: Policies, approach and politics of influencer governance in China
Authors: Xu Jian , Qu Lina , Zhang Ge 
Published: September 2022

AbstractUsing the governance of social eating (chibo) influencers as a case study, this article demonstrates the policies, practices, discourses, and politics of China's state‐centric model of influencer governance. We argue that influencers in China are in a relatively precarious position due to various regulations and restrictions imposed upon them by the state, platforms, and industry associations. They are frequently targeted in China's internet governance campaigns “for a more sanitary internet” and coerced to participate in social governance “for the creation of a better socialist society.” They are therefore vulnerable within China's state‐controlled digital economy, caught between risks and opportunities this governance affords. Their position in this governance regime has consequently enabled their creativity, flexibility, and resilience to “play on the edge” of recurring platform crackdowns and capricious government policies to survive in the ever‐changing influencer industry. The coevolution of regulatory policies and focuses, and the shifting performativity of influencers, also makes China's influencer culture fast evolving and the governance itself more complex than elsewhere.
Effects of continuous aerobic training associated with resistance training on maximal and submaximal exercise tolerance, fatigue, and quality of life of patients post‐COVID‐19
Authors: Araújo Bruna T. S. , Barros Ana Eugênia V. R. , Nunes Daiara T. X. , Remígio de Aguiar Maria Inês , Mastroianni Viviane W. , de Souza Juliana A. F. , Fernades Juliana , Campos Shirley Lima , Brandão Daniella Cunha , Dornelas de Andrade Armele 
Published: September 2022

AbstractBackground and PurposeDyspnea, fatigue, and reduced exercise tolerance are common in post‐COVID‐19 patients. In these patients, rehabilitation can improve functional capacity, reduce deconditioning after a prolonged stay in the intensive care unit, and facilitate the return to work. Thus, the present study verified the effects of cardiopulmonary rehabilitation consisting of continuous aerobic and resistance training of moderate‐intensity on pulmonary function, respiratory muscle strength, maximum and submaximal tolerance to exercise, fatigue, and quality of life in post‐COVID‐19 patients.MethodsQuasi‐experimental study with a protocol of 12 sessions of an outpatient intervention. Adults over 18 years of age (N = 26) with a diagnosis of COVID‐19 and hospital discharge at least 15 days before the first evaluation were included. Participants performed moderate‐intensity continuous aerobic and resistance training twice a week. Maximal and submaximal exercise tolerance, lung function, respiratory muscle strength, fatigue and quality of life were evaluated before and after the intervention protocol.ResultsCardiopulmonary rehabilitation improved maximal exercise tolerance, with 18.62% increase in peak oxygen consumption (VO2peak) and 29.05% in time to reach VO2peak. VE/VCO2slope reduced 5.21% after intervention. We also observed increased submaximal exercise tolerance (increase of 70.57 m in the 6‐min walk test, p = 0.001), improved quality of life, and reduced perceived fatigue after intervention.DiscussionPatients recovered from COVID‐19 can develop persistent dysfunctions in almost all organ systems and present different signs and symptoms. The complexity and variability of the damage caused by this disease can make it difficult to target rehabilitation programs, making it necessary to establish specific protocols. In this work, cardiopulmonary rehabilitation improved lung function, respiratory muscle strength, maximal and submaximal exercise tolerance, fatigue and quality of life. Continuous aerobic and resistance training of moderate intensity proved to be effective in the recovery of post‐COVID‐19 patients.
Cyclic cystine knot and its strong implication on the structure and dynamics of cyclotides
Authors: Venkatesan Jayapriya , Roy Durba 
Published: September 2022

AbstractThe archetypal Viola odorata cyclotide cycloviolacin‐O1 and its seven analogs, created by partial or total reduction of the three native S–S linkages belonging to the “cyclic cystine knot” (CCK) motif are studied for their structural and dynamical diversities using molecular dynamics simulations. The results indicate interesting interplay between the constraints imposed by the S–S bonds on the dynamical modes and the corresponding structure of the model peptide. Principal component analysis brings out the variation in the extent of dynamical freedom along the peptide backbone for each model. The motions are characterized by low amplitude diffusive modes in the peptides retaining most of the native S–S linkages in contrast to the large amplitude discrete jumps where at least two or all of the three S–S linkages are reduced. Simulation results further indicate that the disulfide bond between Cys1–18 is formed at a much faster pace compared with its two other peers Cys5–20 and Cys10–25 as found in the native peptide. This gives insight as to why the S–S linkages appear in the native peptide in a particular combination. Model therapeutics and drug delivery engines can potentially utilize this information to customize the engineered S–S bonds and gauge its impact on the dynamic flexibility of a model macrocyclic peptide.
Volatile‐mediated tritrophic defense and priming in neighboring maize against Ostrinia furnacalis and Mythimna separata
Authors: Foba Caroline Ngichop , Shi Jin‐Hua , An Qing‐Qing , Liu Le , Hu Xin‐Jun , Hegab Mahmoud Ali Morse Soliman , Liu Hao , Zhao Pei‐Min , Wang Man‐Qun 
Published: September 2022

AbstractBackgroundPlants respond to attackers by triggering phytohormones signaling associated metabolites, including herbivore‐induced plant volatiles (HIPVs). HIPVs can indirectly act against herbivory by recruitment of natural enemies and priming of neighboring plants. Ostrinia furnacalis and Mythimna separata are important insect herbivores of maize plants that have a devastating influence on yield. However, little is known about how maize temporally reconfigures its defense systems against these herbivores and variation of neighboring plant resistance.ResultsThis study investigated the effects of HIPVs on the behavior of the dominant predatory beetle Harmonia axyridis and priming in neighboring maize defense against O. furnacalis and M. separata over time. The results showed that maize damaged by either O. furnacalis or M. separata enhanced the release of volatiles including terpenes, aldehydes, alkanes and an ester, which elicited an increased attractive response to H. axyridis after 3 and 12 h, respectively. O. furnacalis damage resulted in accumulations of leaf jasmonic acid (JA) and salicylic acid in maize after 6 and 3 h, respectively, while M. separata damage only raised the JA level after 3 h. Furthermore, HIPVs were able to prime neighboring plants through the accumulation of JA after 24 h. Both larvae showed a significant decrease in weight accumulation after 48 h of feeding on the third leaves of the primed plant.ConclusionTaken together, the findings provide a dynamic overview of how attacked maize reconfigures its volatiles and phytohormones to defend against herbivores, as well as priming of neighboring plants against oncoming attacks. © 2022 Society of Chemical Industry.
Robust monitoring of multivariate processes with short‐ranged serial data correlation
Authors: Xie Xiulin , Qiu Peihua 
Published: September 2022

AbstractControl charts are commonly used in practice for detecting distributional shifts of sequential processes. Traditional statistical process control (SPC) charts are based on the assumptions that process observations are independent and identically distributed and follow a parametric distribution when the process is in‐control (IC). In practice, these assumptions are rarely valid, and it has been well demonstrated that these traditional control charts are unreliable to use when their model assumptions are invalid. To overcome this limitation, nonparametric SPC has become an active research area, and some nonparametric control charts have been developed. But, most existing nonparametric control charts are based on data ordering and/or data categorization of the original process observations, which would result in information loss in the observed data and consequently reduce the effectiveness of the related control charts. In this paper, we suggest a new multivariate online monitoring scheme, in which process observations are first sequentially decorrelated, the decorrelated data of each quality variable are then transformed using their estimated IC distribution so that the IC distribution of the transformed data would be roughly N(0, 1), and finally the conventional multivariate exponentially weighted moving average (MEWMA) chart is applied to the transformed data of all quality variables for online process monitoring. This chart is self‐starting in the sense that estimates of all related IC quantities are updated recursively over time. It can well accommodate stationary short‐range serial data correlation, and its design is relatively simple since its control limit can be determined in advance by a Monte Carlo simulation. Because information loss due to data ordering and/or data categorization is avoided in this approach, numerical studies show that it is reliable to use and effective for process monitoring in various cases considered.
Do changes in the business environment and sustainable development really matter for enhancing enterprise development?
Authors: Brychko Maryna , Bilan Yuriy , Lyeonov Serhiy , Streimikiene Dalia 
Published: September 2022

AbstractThe accomplishment of sustainable development goals has become a global initiative to encourage renewable energy, reduce wasteful energy consumption and increase investment in energy efficiency projects. The number of publications devoted to sustainable development, environmental protection and green investments is growing exponentially. Firstly, this study is committed to provide a comprehensive overview of research literature on enterprise development in decades‐long, focusing on the sustainable development and business environment field. Secondly, it seeks to elaborate the most comprehensive structural model examining the multilateral and facilitative role of internal and external business environment changes in the relationship between sustainable development and enterprise development. A bibliometric analysis via VOSviewer was applied to detect and visualize the research trends and display the research status of enterprise development under the changes in the business environment and sustainable development. A confirmatory factor analysis and structural equation modeling were performed to develop, implement and verify a conceptual structural model examining the multilateral and facilitative role of internal and external business environment changes in the relationship between sustainable development and enterprise development. Mapping bibliographic data based on co‐citation, co‐occurrence, bibliographic coupling, and network and content analysis showed that generally, researchers had made significant efforts to investigate different links that arise between enterprises development, sustainable development, and business environment separately in different combinations. Structural equation modeling showed that the argument that sustainable development directly causes enterprise development is disputable since sustainable development focuses on changes in the internal and external business environment that eventually influence enterprise development, which in turn leads to a further new shift in the external environment.
Method for Detecting Sources Cited with Browsing to Prevent Reference Omissions
Authors: Ishizawa Chikako , Makabe Hiroyuki , Ito Yudai , Kageyama Yoichi 
Published: September 2022

AbstractThis study demonstrates the gaze position on a PC monitor while typing with and without browsing any sources. Six subjects (touch‐typing and non‐touch‐typing) entered text with and without browsing a web page, and we analyzed the percentage of gaze on each window of the software running on the monitor. The proposed method comprises three steps: detecting the entry operation of a word processor or text editor, determining the browsing in inactive windows, and outputting the referenced source title. Experiments show that the proposed method can accurately determine whether any source is browsed during the entry operation. © 2022 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
An integrative cellular metabolomic study reveals downregulated tricarboxylic acid cycle and potential biomarkers induced by tetrabromobisphenol A in human lung A549 cells
Authors: He Hailang , Pan Tingyu , Shi Xiaojian , Yang Shuang , Jasbi Paniz , Jin Yan , Cui Julia Yue , Gu Haiwei 
Published: September 2022

AbstractTetrabromobisphenol A (TBBPA) is extensively utilized as a brominated flame retardant in numerous chemical products. As an environmental contaminant, the potential human toxicity of TBBPA has been attracting increasing attention. Nonetheless, the exact underlying mechanisms of toxicological effects caused by TBBPA remain uncertain. In this study, we investigated the potential mechanisms of TBBPA toxicity in vitro in the A549 cell line, one of the widely used type II pulmonary epithelial cell models in toxicology research. Cell viability was determined after treatment with varying concentrations of TBBPA. Liquid chromatography–mass spectrometry (LC–MS) metabolomics and metabolic flux approaches were utilized to evaluate metabolite and tricarboxylic acid (TCA) cycle oxidative flux changes. Our findings demonstrated that TBBPA significantly reduced the viability of cells and attenuated mitochondrial respiration in A549 cells. Additionally, LC–MS data showed significant reductions in TCA cycle metabolites including citrate, malate, fumarate, and alpha‐ketoglutarate in 50 μM TBBPA‐treated A549 cells. Metabolic flux analysis indicated reduced oxidative capacity in mitochondrial metabolism following TBBPA exposure. Moreover, diverse metabolic pathways, particularly alanine, aspartate, and glutamate metabolism and the TCA cycle, were found to be dysregulated. In total, 12 metabolites were significantly changed (p < .05) in response to 50 μM TBBPA exposure. Our results provide potential biomarkers of TBBPA toxicity in A549 cells and help elucidate the molecular mechanisms of pulmonary toxicity induced by TBBPA exposure.
Instability of the electroweak vacuum in Starobinsky inflation
Authors: Li Qiang , Moroi Takeo , Nakayama Kazunori , Yin Wen 
Published: September 2022

Abstract
We study the stability of the electroweak vacuum during and after the Starobinky inflation, assuming the existence of the non-minimal Higgs coupling to the Ricci scalar. In the Starobinsky inflation, there exists R2 term (with R being the Ricci scalar), which modifies the evolution equation of the Higgs field. We consider the case that the non-minimal coupling is sizable so that the quantum fluctuation of the Higgs field is suppressed and that the Higgs amplitude is settled near the origin during the inflation. In such a case, the Higgs amplitude may be amplified in the preheating epoch after inflation because of the parametric resonance due to the non-minimal coupling. We perform a detailed analysis of the evolution of the Higgs field in the preheating epoch by a numerical lattice simulation and derive an upper bound on the non-minimal coupling constant ξ in order to realize the electroweak vacuum in the present universe. We find that the upper bound on ξ in the Starobinsky inflation model is more stringent than that in conventional inflation models without the R2 term.
Solutions to nonlocal evolution equations governed by non-autonomous forms and demicontinuous nonlinearities
Authors: Colao Vittorio , Muglia Luigi 
Published: September 2022

AbstractWe deal with the existence of solutions having $$L^2$$

L
2

-regularity for a class of non-autonomous evolution equations. Associated with the equation, a general non-local condition is studied. The technique we used combines a finite dimensional reduction together with the Leray–Schauder continuation principle. This approach permits to consider a wide class of nonlinear terms by allowing demicontinuity assumptions on the nonlinearity.