bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aetiology and Potential Animal Exposure in Central Nervous System Infections in Vietnam
Authors: Brindle Hannah E. , Nadjm Behzad , Choisy Marc , Christley Rob , Griffiths Michael , Baker Stephen , Bryant Juliet E. , Campbell James I. , Nguyen Van Vinh Chau , Nguyen Thi Ngoc Diep , Vu Ty Thi Hang , Nguyen Van Hung , Hoang Bao Long , Le Xuan Luat , Pham Ha My , Ta Thi Dieu Ngan , Ho Dang Trung Nghia , Tran Thua Nguyen , Nguyen Thi Han Ny , Tran My Phuc , Pham Thi Hong Phuong , Le Van Tan , Nguyen Dac Thuan , Hau Thi Thu Trang , Nguyen Ngoc Vinh , Wertheim Heiman F. L. , Thwaites Guy E. , van Doorn H. Rogier ,   the VIZIONS Consortium
Published: October 2022

AbstractAn estimated 73% of emerging infections are zoonotic in origin, with animal contact and encroachment on their habitats increasing the risk of spill-over events. In Vietnam, close exposure to a wide range of animals and animal products can lead to acquisition of zoonotic pathogens, a number of which cause central nervous system (CNS) infections. However, studies show the aetiology of CNS infections remains unknown in around half of cases. We used samples and data from hospitalised patients with CNS infections, enrolled into the Vietnam Initiative on Zoonotic Infections multicentre study, to determine the association between aetiology and animal contact including those in whom the cause was unknown. Among 933 patients, a pathogen or an antibody response to it was identified in 291 (31.2%, 95% CI 28.3–34.3%). The most common pathogens were Streptococcus suis (n = 91 (9.8%, 8.0–11.9%)) and Japanese encephalitis virus (JEV) (n = 72 (7.7%, 6.1–9.7%)). Commonly reported animal contact included keeping, raising or handling (n = 364 (39.0%, 35.9–42.2%)) and handling, cooking or consuming raw meat, blood or viscera in the 2 weeks prior to symptom onset (n = 371 (39.8%, 36.6–43.0%)), with the latter most commonly from pigs (n = 343 (36.9%, 33.8–40.1%). There was no association between an unknown aetiology and exposure to animals in a multivariate logistic regression. Further testing for unknown or undetected pathogens may increase diagnostic yield, however, given the high proportion of zoonotic pathogens and the presence of risk factors, increasing public awareness about zoonoses and preventive measures can be considered.
One-Pot Transformation of Citronellal to Menthol Over H-Beta Zeolite Supported Ni Catalyst: Effect of Catalyst Support Acidity and Ni Loading
Authors: Taghavi Somayeh , Mäki-Arvela Päivi , Vajglová Zuzana , Peurla Markus , Angervo Ilari , Eränen Kari , Ghedini Elena , Menegazzo Federica , Zendehdel Mojgan , Signoretto Michela , Murzin Dmitry Yu. 
Published: October 2022

AbstractCitronellal was converted to menthol in a one-pot approach using H-Beta zeolite-based Ni catalyst in a batch reactor at 80 °C, under 20 bar of total pressure. The effects of H-Beta acidity (H-Beta-25 with the molar ratio SiO2/Al2O3 = 25 and H-Beta-300 with SiO2/Al2O3 = 300) and Ni loading (5, 10 and 15 wt %) on the catalytic performance were investigated. Ni was impregnated on H-Beta support using the evaporation-impregnation method. The physico-chemical properties of the catalysts were characterized by XRD, SEM, TEM, ICP-OES, N2 physisorption, TPR, and pyridine adsorption–desorption FTIR techniques. Activity and selectivity of catalysts were strongly affected by the Brønsted and Lewis acid sites concentration and strength, Ni loading, its particle size and dispersion. A synergetic effect of appropriate acidity and suitable Ni loading in 15 wt.% Ni/H-Beta-25 catalyst led to the best performance giving 36% yield of menthols and 77% stereoselectivity to ( ±)-menthol isomer at 93% citronellal conversion. Moreover, the catalyst was successfully regenerated and reused giving similar activity, selectivity and stereoselectivity to the desired ( ±)-menthol isomer as the fresh one.
Graphical Abstract
Independent Supported Housing Versus Institutionalised Residential Rehabilitation for Individuals with Severe Mental Illness: A Survey of Attitudes and Working Conditions Among Mental Healthcare Professionals
Authors: Adamus Christine , Alpiger Jovin , Jäger Matthias , Richter Dirk , Mötteli Sonja 
Published: October 2022

AbstractDespite widespread support for Independent Supported Housing (ISH) interventions, psychiatric housing rehabilitation still commonly takes place in residential care facilities (RCFs). This study compares preferences, attitudes and working conditions of mental healthcare professionals (MHCPs) in ISH and RCFs using an online survey. The survey included setting preferences, stress and strain at work, recovery attitudes, stigmatisation, and factors experienced as particularly important or obstructive in housing rehabilitation. Data were analysed using quantitative and qualitative approaches. Of the 112 participating MHCPs, 37% worked in ISH and 63% in RCFs. Professionals’ education, work-related demands and influence at work were higher in ISH, stigmatising attitudes were higher in RCFs. MHCPs in both settings endorsed ISH. The support process was seen as particularly important whereas stigmatisation, regulatory and political requirements were seen as obstructive for successful housing rehabilitation. Results indicate that social inclusion of individuals with severe mental illness is seldom feasible without professional support.
Use of orange peel extract as an inhibitor of stainless steel corrosion during acid washing in a multistage flash desalination plant
Authors: Barghout Nehal A. , El Nemr Ahmed , Abd-El-Nabey B. A. , Fetouh H. A. , Ragab Safaa , Eddy Nnabuk Okon 
Published: October 2022

AbstractEnvironmentally friendly and cost-effective inhibitors based on orange peel extract (OPE) have been developed for potential applications in ejector tubes of a multistage desalination plant during the acid cleaning process. After conducting tests under both static and hydrodynamic circumstances, it was determined that the inhibitor formulation was effective against corrosion of stainless steel (SS) in 1 M HCl solution at 30 °C under the conditions tested. Electrochemical methods were used along with electron microscopy to collect information on the corrosion inhibition efficiency of the extract. Experiments were conducted for 1, 2, 3, 4, 6, 12, and 24 h, and the performance of OPE was compared to that of a commercial acid corrosion inhibitor to determine which performed better. The results revealed that OPE demonstrated outstanding corrosion inhibition performance compared to the commercial acid corrosion inhibitor. With remarkable inhibition efficacy for up to 24 h under both static and dynamic settings, 0.4% of OPE displayed typical mixed-type corrosion inhibitor behavior in the tested environment. All of the procedures that were used produced results that were in good agreement. Due to the synergistic action between the two compounds, the corrosion inhibition of OPE on SS was improved in 1 M HCl in the presence of iodide ions. In the absence of KI, OPE was found to inhibit SS corrosion at a concentration-dependent rate, with the concentration of OPE being the most significant factor. A study of the adsorption of OPE onto a SS surface revealed that the Langmuir adsorption isotherm controls the process. Based on the quantity of free energy of adsorption observed, it was determined that there is physical contact between the OPE and the surface of SS in this experiment. It was possible to identify the most effective phytochemicals for corrosion inhibition based on the findings of quantum chemical calculations, which were subsequently evaluated in the laboratory.
Graphical abstract
Higher Sensory Sensitivity is Linked to Greater Expansion Amongst Functional Connectivity Gradients
Authors: del Río Magdalena , Racey Chris , Ren Zhiting , Qiu Jiang , Wang Hao-Ting , Ward Jamie 
Published: October 2022

AbstractInsofar as the autistic-like phenotype presents in the general population, it consists of partially dissociable traits, such as social and sensory issues. Here, we investigate individual differences in cortical organisation related to autistic-like traits. Connectome gradient decomposition based on resting state fMRI data reliably reveals a principal gradient spanning from unimodal to transmodal regions, reflecting the transition from perception to abstract cognition. In our non-clinical sample, this gradient's expansion, indicating less integration between visual and default mode networks, correlates with subjective sensory sensitivity (measured using the Glasgow Sensory Questionnaire, GSQ), but not other autistic-like traits (measured using the Autism Spectrum Quotient, AQ). This novel brain-based correlate of the GSQ demonstrates sensory issues can be disentangled from the wider autistic-like phenotype.
Resonance ionization of zirconium
Authors: Trappitsch R. , Shulaker D. Z. , Ong W.-J. , Savina M. R. , Isselhardt B. H. 
Published: October 2022

AbstractMeasuring the isotopic composition of trace Zr in presolar stardust grains allows us to study the environment of slow neutron-capture nucleosynthesis in asymptotic giant branch stars. Here, we present a newly characterized Zr resonance ionization scheme that can be saturated with state-of-the-art titanium-sapphire lasers and yields a useful yield of (5.4 ± 0.4)%. Resonance ionization is achieved in two steps: after first being excited with a photon at 319.215 nm, neutral Zr atoms are then ionized with a photon at 388.988 nm, where both wavelengths are reported as in vacuum.
The Swedish version of the Anterior Cruciate Ligament Quality Of Life measure (ACL-QOL): translation and measurement properties
Authors: Filbay Stephanie R. , Grevnerts Hanna Tigerstrand , Sonesson Sofi , Hedevik Henrik , Kvist Joanna 
Published: October 2022

AbstractPurposeTo translate the ACL-QOL from English to Swedish and evaluate measurement properties for use after surgical and non-surgical management of anterior cruciate ligament (ACL) injury.MethodsThe ACL-QOL was translated from English to Swedish and data were pooled from 13 cohorts to enable a comprehensive evaluation of measurement properties in line with COSMIN guidelines. We evaluated internal consistency, test–re-test reliability, measurement error, structural validity [confirmatory factor analysis (CFA)], construct validity and responsiveness (hypothesis testing), and floor/ceiling effects. Results were stratified by time since injury (≤ 1.5 years; 2–10 years, 15–25 years; > 30 years) and ACL management strategy [surgical (n = 1163), non-surgical (n = 570)].ResultsThe Swedish ACL-QOL had sufficient internal consistency (total and domain scores) for use in surgically managed (Cronbach’s alpha ≥ 0.744) and non-surgically managed (≥ 0.770) ACL-injured individuals at all time-points. Test–re-test reliability was sufficient [intraclass correlation coefficients: all domains > 0.80, total score 0.93 (95% CI 0.86–0.96)]. The standard error of measurement was 5.6 for the total score and ranged from 7.0 to 10.3 for each domain. CFA indicated sufficient SRMR values when using the total score or five domains; however, CFI and RMSEA values did not meet cut-offs for good model fit. Hypothesis testing indicated sufficient construct validity and responsiveness. Floor effects were negligible and ceiling effects were negligible or minor.ConclusionThe Swedish version of the ACL-QOL has sufficient internal consistency, test–re-test reliability, construct validity and responsiveness, for use in people with ACL injury managed with or without ACL surgery. Model fit could be improved and investigation into the source of misfit is warranted.
The Reflected Face as a Mask of the Self: An Appraisal of the Psychological and Neuroscientific Research About Self-face Recognition
Authors: Volpara Gabriele , Nani Andrea , Cauda Franco 
Published: October 2022

AbstractThis study reviews research about the recognition of one’s own face and discusses scientific techniques (especially the instrument of the mirror) to investigate differences in brain activation when looking at familiar faces compared to unfamiliar ones. Our analysis highlights how people do not possess a perception of their own face that corresponds precisely to reality, and how the awareness of one’s face can also be modulated by means of the enfacement illusion. This illusion allows one to maintain a sense of self at the expense of a precise discrimination of self-face. The internal dynamics of different brain processes, associated with the construction of bodily identity and the sense of self and capable of integrating signals from different sensory channels, particularly visual and tactile, create a mirror-mask effect. According to this effect, the self-face reflected by a mirror becomes a mask for the self, which has the features of the subject’s face, but nonetheless does not correspond perfectly to its characteristics. This poses interesting questions about the nature and construction of one’s self, as self-face reflections allow the mind to mediate between analogue and virtual reality, between past and future events, between memories and plans of action and, most importantly, between beliefs about our identities.
The Multiple Dimensions of Embeddedness of Small Multinational Enterprises
Authors: Vanninen Heini , McNaughton Rod B. , Kuivalainen Olli 
Published: October 2022

AbstractThis research investigates how small multinational enterprises (small MNEs) internationalize by opening branch offices or subsidiaries in foreign markets, managing their multiple embeddedness in their host and home locations, and their subsidiaries’ dual embeddedness in external environments and within their organizations. We study four small multinational enterprises, two each from the small open economies of New Zealand and Finland, and we use literature from entrepreneurship and international business to derive a model of these multiple dimensions of embeddedness. The cases illustrate how firms can become more (or less) embedded in their locations through their physical presence, operations, key employees, and local hires while achieving internal organizational embeddedness through their corporate structure and social and technological bridging. Our research gives insight into how small MNEs may overcome their liabilities of smallness, foreignness, and outsidership by drawing on resources from home and host locations and sharing this throughout the organization.
Mindfulness-Based Strategies for Improving Sleep in People with Psychiatric Disorders
Authors: Peters Allie L. , Saunders William J. , Jackson Melinda L. 
Published: October 2022

Abstract

Purpose of the Review

To review the recent literature on mindfulness-based strategies for improving self-report and objective measures of sleep, in individuals with psychiatric disorders.

Recent Findings

Currently, research provides some support for the use of mindfulness-based interventions to improve sleep amongst individuals with psychiatric comorbidities. The strongest evidence was for the use of standardized programs, particularly for improving sleep in anxiety and depressive disorders. There is a paucity of well-controlled studies using validated subjective or objective measures of sleep. As these interventions were not specifically designed to target sleep, observed improvements may be an indirect consequence of reduced psychiatric symptoms.

Summary

There is insufficient research into the application of mindfulness-based strategies to improve sleep or treat sleep disorders in people with psychiatric disorders. Well-controlled studies using standardized, mindfulness-based interventions developed to target sleep, such as mindfulness-based therapy for insomnia, may optimize the potential benefits of mindfulness for sleep in psychiatric populations.
Quality of data sets that feed AI and big data applications for law enforcement
Authors: Kusak Martyna 
Published: October 2022

AbstractIn the era of big data and artificial intelligence (AI), where aggregated data is used to learn about patterns and for decision-making, quality of input data seems to be of paramount importance. Poor data quality may lead not only to wrong outcomes, which will simply render the application useless, but more importantly to fundamental rights breaches and undermined trust in the public authorities using such applications. In law enforcement as in other sectors the question of how to ensure that data used for the development of big data and AI applications meet quality standards remains. This paper provides an overview of this topic, reporting selected issues stemming from big data, nonpersonal data and regulatory contexts. It concludes that the topic is still underexplored and sets areas for further research.
The Oncogenesis of Glial Cells in Diffuse Gliomas and Clinical Opportunities
Authors: Zhuang Qiyuan , Yang Hui , Mao Ying 
Published: October 2022

AbstractGlioma is the most common and lethal intrinsic primary tumor of the brain. Its controversial origins may contribute to its heterogeneity, creating challenges and difficulties in the development of therapies. Among the components constituting tumors, glioma stem cells are highly plastic subpopulations that are thought to be the site of tumor initiation. Neural stem cells/progenitor cells and oligodendrocyte progenitor cells are possible lineage groups populating the bulk of the tumor, in which gene mutations related to cell-cycle or metabolic enzymes dramatically affect this transformation. Novel approaches have revealed the tumor-promoting properties of distinct tumor cell states, glial, neural, and immune cell populations in the tumor microenvironment. Communication between tumor cells and other normal cells manipulate tumor progression and influence sensitivity to therapy. Here, we discuss the heterogeneity and relevant functions of tumor cell state, microglia, monocyte-derived macrophages, and neurons in glioma, highlighting their bilateral effects on tumors. Finally, we describe potential therapeutic approaches and targets beyond standard treatments.
A Novel de novo KIF1A Mutation in a Patient with Ataxia, Intellectual Disability and Mild Foot Deformity
Authors: Hama Yuka , Date Hidetoshi , Fujimoto Akiko , Matsui Ayano , Ishiura Hiroyuki , Mitsui Jun , Yamamoto Toshiyuki , Tsuji Shoji , Mizusawa Hidehiro , Takahashi Yuji 
Published: October 2022

AbstractEarly-onset ataxias are often difficult to diagnose due to the genetic and phenotypic heterogeneity of patients. Whole exome sequencing (WES) is a powerful method for determining causative mutations of early-onset ataxias. We report a case in which a novel de novo KIF1A mutation was identified in a patient with ataxia, intellectual disability and mild foot deformity.A patient presented with sporadic forms of ataxia with mild foot deformity, intellectual disability, peripheral neuropathy, pyramidal signs, and orthostatic hypotension. WES was used to identify a novel de novo mutation in KIF1A, a known causative gene of neurodegeneration and spasticity with or without cerebellar atrophy or cortical visual impairment syndrome (NESCAVS).We report a novel phenotype of NESCAVS that is associated with a novel de novo missense mutation in KIF1A, which provides valuable information for the diagnosis of NESCAVS even in the era of WES. Early rehabilitation of patients with NESCAVS may prevent symptom worsening and improve the disease course.
Combination bromo- and extraterminal domain and poly (ADP-ribose) polymerase inhibition synergistically enhances DNA damage and inhibits neuroblastoma tumorigenesis
Authors: Jacobson Jillian C. , Qiao Jingbo , Clark Rachael A. , Chung Dai H. 
Published: October 2022

Abstract
Purpose
JQ1 is a bromo- and extraterminal (BET) domain inhibitor that downregulates MYC expression and impairs the DNA damage response. Poly (ADP-ribose) polymerase (PARP) inhibitors prevent DNA damage sensing and repair. We hypothesized that JQ1 would promote a DNA repair-deficient phenotype that sensitizes neuroblastoma cells to PARP inhibition.

Methods
Four human neuroblastoma cell lines were examined: two MYCN-amplified (BE(2)-C and IMR-32), and two non-MYCN-amplified (SK-N-SH and SH-SY5Y). Cells were treated with JQ1 (BET inhibitor), Olaparib (PARP inhibitor), or in combination to assess for therapeutic synergy of JQ1 and Olaparib. Treated cells were harvested and analyzed. Quantitative assessment of combination treatment synergy was performed using the median effect principle of Chou and Talalay.

Results
Combination treatment with Olaparib decreased the IC50 of JQ1 by 19.9-fold, 2.0-fold, 12.1-fold, and 2.0-fold in the BE(2)-C, IMR-32, SK-N-SH, and SH-SY5Y cell lines, respectively. In the MYCN-amplified cell lines, BE(2)-C and IMR-32, combination treatment decreased gene expression of MYCN relative to single-drug treatment alone or control. Combination treatment decreased protein expression of DNA repair proteins Ku80 and RAD51, led to accumulation of DNA damage marker phospho-histone H2A.X, and increased caspase activity. In the non-MYCN-amplified cell lines, SK-N-SH and SH-SY5Y, combination treatment induced G0/G1 cell cycle arrest.

Conclusions
Combination BET and PARP inhibition synergistically inhibited neuroblastoma tumorigenesis in vitro. In MYCN-amplified neuroblastoma cells, this effect may be induced by downregulation of MYCN transcription, defects in DNA repair, accumulation of DNA damage, and apoptosis. In non-MYCN-amplified cell lines, combination treatment induced cell cycle arrest.
A gender approach to time and food security: a case study of Egypt
Authors: ElKhorazaty Noha E. , Zaky Hassan H. M. 
Published: October 2022

AbstractWomen’s subsistence contribution to household food security is undeniable. However, due to the dominance of capital bias in most labour economies, rural women in particular lack agency to improve capacity and access to resources and opportunities, and they need to be more productive. This knowledge gap is the subject of many studies on sustainable agricultural development and gender equity. Although the consensus necessitates policy interventions targeting the gender gap in agriculture resources, not enough research has been dedicated to quantifying the importance of women subsistence agricultural labour within the Egyptian national context. This article seeks to statistically analyse women’s role in subsistence agriculture, estimated by a national time-use survey conducted in 2018 in Egypt. The goal is to highlight their capacity to contribute to food and nutrition security and quantify the real impact of rural women’s subsistence agriculture labour on rural household food security versus that of rural men. This will contribute to the debate that investigating rural women in agriculture promotes rural community sustainability and highlights their capacity for agricultural production.