bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ektacytometric elongation Index (EI) of erythrocytes, validation of a prognostic, rheological biomarker for patients with sickle cell disease
Authors: Franck Paul , Buijs Petra , Meenhuis Annemarie , Dane Martijn , Postma Cobie , Spaans Anja , Gijsbertha Niegel , Kuypers Frans A. , Hudig Cisca , Kerkhoffs Jean Louis 
Published: January 2022

AbstractObjectivesValidation of the measurement of erythrocyte deformability as a useful prognostic, rheological biomarker for patients with sickle cell disease (SCD).MethodsThe degree of reduced deformability was based on the value of the maximum elongation index (EImax) of the deformability curve of an osmotic gradient ektacytometer. The performance of this technique was analytically and clinically validated by analysing 200 normal subjects and 100 patients with well‐documented thalassemia's and Hb variants in relation to their clinical condition.ResultsIn this study, we show that EImax is a reproducible parameter with a small inter‐individual coefficient of (Biological) variation (CV)=1.6% and a small intra‐individual CV=3.5%. We demonstrate that loss of deformability correlates with the clinical condition and the various mutations underlying sickle cell disease and thalassemia. For SCD patients, a strongly reduced EImax with a cut‐off =0.360 is a signal for future vaso‐occlusive (VOC) events requiring hospitalisation with a specificity=85%, sensitivity=80%, PPV=81% and NPV=84% based on a ROC curve (AUC=0.89).ConclusionThis study validated the clinical utility of EImax as a prognostic marker for future clinical problems in individual high‐risk SCD patients. In addition, EImax may help to achieve an adequate personal transfusion policy for an optimal blood flow in anaemic patients with SCD.
Djaara cultural authority drives inclusion of their knowledge and culture in a Joint Management Plan for parks
Authors: Carter Rodney , Atkinson Graham , Burchill Marlene , Phillips Rebecca , Humann Doug , Mahoney Jan , Miles Trevor , Braid Michele , Buissereth Rachel , Cowell Stuart , Hill Rosemary , Huggins Barbara , Jackson Steve , Raisbeck‐Brown Nat , Talbot Leah , Wong Nathan 
Published: January 2022

SummarySix parks in central Victoria were handed back to ownership of Dja Dja Wurrung People (Djaara) as part of the Recognition and Settlement Agreement 2013 with the State of Victoria. Dhelkunya Dja Land Management Board (DDLMB) developed a Joint Management Plan (JMP) for these parks, which was approved under Victorian legislation and launched in October 2018. Here, we show how and why Djaara used their cultural authority to ensure their knowledge, and culture was incorporated into the JMP. Djaara’s cultural authority produced significant innovations. First, the unique Free, Prior and Informed Consent (FPIC) processes implemented by the Dja Dja Wurrung Clans Aboriginal Corporation (DDWCAC) for the DDLMB ensured that shared governance and decision‐making underpinned joint management. Second, the participatory Healthy Country Planning approach enabled greater equity, including a unique 3‐day ‘Map‐a‐Thon’ that integrated cultural and natural spatial data. Third, the challenge of achieving power‐shifting from the government to the Djaara was addressed through a relationship‐based approach, supported by systematic, evidence‐based planning. The DDLMB and DDWCAC ensured development of the final JMP was innovative, equitable, culturally appropriate and culturally informed. Future processes would be improved by legislative change to mandate FPIC, with substantially greater resources to support the FPIC processes, and the inclusion of a ‘planning to plan’ stage to allow all participants to gain the capacities needed. Supporting the cultural authority of Traditional Owners provides a new direction that has much to offer planning for other joint‐managed parks in Victoria and elsewhere.
Influence of oceanographic conditions on the body shape variability of Scomber japonicus larvae from the western coast of the Baja California Peninsula
Authors: Anaya‐Godínez Eduardo , Silva‐Segundo Claudia A. , Landaeta Mauricio F. , Funes‐Rodríguez René , Trujillo‐Millán Oscar , Blanco‐Jarvio Anidia , Galván‐Tirado Carolina , Valenzuela‐Quiñonez Fausto , Marín‐Enríquez Emigdio 
Published: January 2022

AbstractPacific chub mackerel (Scomber japonicus) is a relevant fishery resource shared among three countries in the northeastern Pacific. The spatiotemporal distribution of larvae has been related to the convergence of oceanographic mesoscale structures, which can generate considerable variability in the morphology of fish larvae. The main goal of this work was to describe the shape changes of larval S. japonicus and their relationship with oceanographic variability, through geometric morphometric analysis to assess the seasonal variability of 10 homologous landmarks distributed on the pre‐anal section of 331 larvae from off the western coast of the Baja California Peninsula (WCBCP), Mexico (2006–2008). The results showed two principal morphotypes in Pacific chub mackerel larvae: The first morphotype had a more hydrodynamic body (longer and shallower head), influenced by increased sea surface flow and colder sea surface temperatures mainly during spring, and the second morphotype had robust larvae (shorter and deeper head) under slower current flow and warmer sea surface temperatures during winter and summer. We concluded that changes in larval body shape are influenced mainly by sea surface flow and sea temperatures, probably associated with the ability to reach higher swimming speeds during feeding success.
An improved representation of the relationship between photosynthesis and stomatal conductance leads to more stable estimation of conductance parameters and improves the goodness‐of‐fit across diverse data sets
Authors: Lamour Julien , Davidson Kenneth J. , Ely Kim S. , Le Moguédec Gilles , Leakey Andrew D. B. , Li Qianyu , Serbin Shawn P. , Rogers Alistair 
Published: January 2022

AbstractStomata play a central role in surface–atmosphere exchange by controlling the flux of water and CO2 between the leaf and the atmosphere. Representation of stomatal conductance (gsw) is therefore an essential component of models that seek to simulate water and CO2 exchange in plants and ecosystems. For given environmental conditions at the leaf surface (CO2 concentration and vapor pressure deficit or relative humidity), models typically assume a linear relationship between gsw and photosynthetic CO2 assimilation (A). However, measurement of leaf‐level gsw response curves to changes in A are rare, particularly in the tropics, resulting in only limited data to evaluate this key assumption. Here, we measured the response of gsw and A to irradiance in six tropical species at different leaf phenological stages. We showed that the relationship between gsw and A was not linear, challenging the key assumption upon which optimality theory is based—that the marginal cost of water gain is constant. Our data showed that increasing A resulted in a small increase in gsw at low irradiance, but a much larger increase at high irradiance. We reformulated the popular Unified Stomatal Optimization (USO) model to account for this phenomenon and to enable consistent estimation of the key conductance parameters g0 and g1. Our modification of the USO model improved the goodness‐of‐fit and reduced bias, enabling robust estimation of conductance parameters at any irradiance. In addition, our modification revealed previously undetectable relationships between the stomatal slope parameter g1 and other leaf traits. We also observed nonlinear behavior between A and gsw in independent data sets that included data collected from attached and detached leaves, and from plants grown at elevated CO2 concentration. We propose that this empirical modification of the USO model can improve the measurement of gsw parameters and the estimation of plant and ecosystem‐scale water and CO2 fluxes.
The ratio of serum des‐gamma‐carboxy prothrombin to tumor volume as a new biomarker for early recurrence of resected hepatocellular carcinoma
Authors: Shimagaki Tomonari , Yoshizumi Tomoharu , Itoh Shinji , Iseda Norifumi , Tomiyama Takahiro , Morinaga Akinari , Wang Huanlin , Kurihara Takeshi , Nagao Yoshihiro , Toshima Takeo , Harada Noboru , Kinjo Nao , Maeda Takashi , Mori Masaki 
Published: January 2022

AbstractBackgroundEarly recurrence (ER) of hepatocellular carcinoma (HCC) (within 1 year after resection) is known to be a poor prognostic factor. The aim was to identify the risk factors associated with ER after HCC resection.MethodsData were analyzed retrospectively from patients who underwent primary resection for HCC from two hospitals. For cross‐validation, HCC resection cases were divided into the training and testing cohort. The clinicopathological factors between the ER and non‐ER groups and factors for predicting ER and prognosis after HCC resection were compared.ResultsOut of 173 patients in the training dataset, 33 patients had ER and the ER group showed larger tumor size, more intrahepatic metastasis (IM), and a higher ratio of serum des‐gamma‐carboxy prothrombin (DCP) to tumor volume (TV) (DCP/TV) than the non‐ER group. Out of 203 patients in the testing dataset, 30 patients had ER and the ER group demonstrated larger tumor size, more IM, and higher serum alpha‐fetoprotein, AFP/TV, DCP/TV, AFP/tumor maximum diameter (TMD), and DCP/TMD than the non‐ER group. The patients were divided into high and low DCP/TV groups and high serum DCP/TV was associated with unfavorable overall survival in the training and testing dataset. Multivariate analysis confirmed that high serum DCP/TV and IM were independently associated with ER.ConclusionPreoperative high serum DCP/TV may be useful for stratifying patients at risk of early HCC recurrence after curative resection.
Epidemiology of dermatologic disease in Palau: a cross‐sectional study in the national public and community health service
Authors: Lee Wan‐Ting J. , Lee Chien‐Chang , Wu Chung‐Kuan , Lin Ching‐Hwa , Lo Te‐Yu , Huang Chieh‐Chen , Kahler Sam L. , Thong Haw‐Yueh 
Published: January 2022

AbstractBackgroundDermatologic disease is a neglected public health challenge that disproportionately affects resource‐poor settings. Globally, dermatologic disease contributes the fourth highest burden of nonfatal disability with the most acute impact in the Oceanic region, including the Republic of Palau. Efforts to address the dermatologic health inequality are hindered without the necessary epidemiologic evidence to guide health policy in the resource‐poor setting of Palau.MethodsWe conducted a 4‐year cross‐sectional study of all Dermatology Service patients in the Belau National Hospital and outreach community health centers from 2015 to 2018. No other specialized dermatology service was available. Skin disease was classified by both diagnosis and Global Burden of Disease criteria and analyzed by age, gender, region, and surrounding Oceanic nations.ResultsThe study enrolled 494 patients comprising 179 males and 315 females between 2015 and 2018. The most prevalent diseases were eczema (48.8%), superficial fungal infection (24.5%), and pruritus (22.7%). The neglected tropical disease of scabies was detected in four patients. Males were significantly more likely to present with cellulitis, keratinocyte carcinoma, stasis dermatitis, wounds, marine‐related dermatitis, viral skin disease, tinea faciei, verruca, and xerosis and females with melasma and hyperpigmentation.ConclusionThis study presents the first primary epidemiologic data describing the prevalence of dermatologic disease in the Palauan adult population. The significant burden of disease in Palau compared with other Oceanic nations validates ongoing dermatology services and informs public health implications for resource allocation and disease management to achieve health equality in the resource‐poor nation.
How effective are integration policy reforms? The case of asylum‐related migrants
Authors: Pecoraro Marco , Manatschal Anita , Green Eva G. T. , Wanner Philippe 
Published: January 2022

AbstractThe marked increase of asylum seekers arriving in Western Europe after 2014 has renewed debates on policy measures that countries should put into place to support their integration. Although implemented by many countries in recent years, research has neglected the effect of integration policy reform packages combining economic and social policy measures on asylum‐related immigrants’ adjustment processes. Exploiting a comprehensive integration policy reform in Switzerland, using survey data from the Health Monitoring of the Swiss Migrant Population, and registering data on the whole asylum‐related population, our difference‐in‐differences analyses reveal that provisionally admitted individuals benefiting from the reform have higher employment probability, increased income levels, better language skills, and feel less lonely or without a homeland relative to comparable asylum seekers who did not benefit from the reform. Robustness checks assessing common pre‐reform trends support our findings, which highlight the importance of evaluating entire reform packages when assessing integration policies’ effectiveness.
Experiences of oncology nurses regarding self‐compassion and compassionate care: A qualitative study
Authors: Serçe Yüksel Özgü , Partlak Günüşen Neslihan , Çelik Ince Sevecen , Zeybekçi Solmaz 
Published: January 2022

AbstractAimThe aim of this study was to explore the experiences of oncology nurses about self‐compassion and compassionate care.BackgroundThe concept of self‐care is emphasized in detail in the literature, and not much is known about the concept of self‐compassion among nurses. Beyond the definitions of self‐compassion and compassion in the literature, there is a need to explore and express the meaning of self‐compassion and compassion in the context of oncology nursing.MethodsThis is a descriptive qualitative study. Semistructured interviews were conducted with 19 oncology nurses working in the oncology service of a university hospital. Interviews were analyzed using thematic analysis through an inductive approach. Consolidated criteria for reporting qualitative studies (COREQ) were used to ensure the comprehensive reporting of this qualitative study protocol.ResultsTwo themes emerged: (1) compassion through the eyes of oncology nurses and barriers to compassionate care fall under the theme of wounded healers, and (2) self‐compassion through the eyes of oncology nurses, barriers to self‐compassion, and self‐care as a dimension of self‐compassion fall under the theme of caring for our suffering: self‐compassion.ConclusionsAlthough nurses think that self‐compassion is important, they do not show self‐compassion. There are personal and organizational barriers to compassionate care and self‐compassion for oncology nurses.Implications for nursing policyThese findings show that oncology nurses need personal and organizational resources for their self‐compassion. The existence of programs to develop self‐compassion can offset the effects of being in a caregiving position. Oncology nurses must request these services from organization, managers and even policymakers. The existence of policies that also consider the mental health of nurses can pave the way for compassionate care.
‘It Is You in My Picture!’ A Holistic Approach toSix‐Year‐OldChildren’s Art Experiences
Authors: Granö Päivi , Turunen Serja 
Published: January 2022

AbstractThe case study is a part of the research and art‐based developmental project Rinnalla (Side by Side) – Mentors of Arts‐ and Narrative‐based Approaches as a Support for Social‐Emotional Learning and Growth in Early Childhood Education, where arts and narrative‐based methods were used to support children’s social‐emotional growth in early childhood education. This research focuses on six‐year‐old children’s experiences of a fairy tale and music based on H.C. Andersen’sThe Ugly Duckling. The research questions are: (1) How do children express the emotions they experience while listening to a fairy tale and music? (2) How do the children express and build their peer relationships through communication while drawing? The intervention was implemented in a preschool group of 15 children. The data included around 120 minutes of recorded video and 30 drawings. The holistic and context‐sensitive interpretation method of visual analysis was used to analyse the data. The interpretation demonstrated the importance of peer relationships and offered insight into the context significance. By drawing together and telling small stories in a shared time and place, the children negotiated their roles within the small group. They strengthened friendships and built peer relations. The drawing situation probably exposed pre‐existing tensions between the children, and the children showed interest, support, care, and willingness to welcome others. The music and fairy tale experiences allowed children to process emotions and share their current daily lives.
Influence of age on stem cells depends on the sex of the bone marrow donor
Authors: Selle Michael , Koch Johanna Dorothea , Ongsiek Alina , Ulbrich Linnea , Ye Weikang , Jiang Zhida , Krettek Christian , Neunaber Claudia , Noack Sandra 
Published: January 2022

AbstractAgeing is often accompanied by an increase in bone marrow fat together with reduced bone volume and diseases of the bone such as osteoporosis. As mesenchymal stem cells (MSCs) are capable of forming bone, cartilage and fat tissue, studying these cells is of great importance to understand the underlying mechanisms behind age‐related bone diseases. However, inter‐donor variation has been found when handling MSCs. Therefore, the aim of this study was to investigate the effects of donor age and sex by comparing in vitro characteristics of human bone marrow‐derived MSCs (hBMSCs) from a large donor cohort (n = 175). For this, hBMSCs were analysed for CFU‐F capacity, proliferation, differentiation capacity and surface antigen expression under standardized culture conditions. The results demonstrated a significantly reduced CFU‐F number for hBMSCs of female compared to male donors. Furthermore, there was a significant decrease in the proliferation rate, adipogenic differentiation potential and cell surface expression of SSEA‐4, CD146 and CD274 of hBMSCs with an increase in donor age. Interestingly, all these findings were exclusive to hBMSCs from female donors. Further research should focus on postmenopausal‐related effects on hBMSCs, as the results imply a functional loss and immunophenotypic change of hBMSCs particularly in aged women.
Outcome measures and methods of assessment of soft tissue augmentation interventions in the context of dental implant therapy: A systematic review of clinical studies published in the last 10 years
Authors: Avila‐Ortiz Gustavo , Couso‐Queiruga Emilio , Pirc Miha , Chambrone Leandro , Thoma Daniel S. 
Published: January 2022

AbstractAimTo identify and report outcome measures and methods of assessment on soft tissue augmentation interventions in the context of dental implant therapy reported in clinical studies published in the last 10 years.Materials and MethodsThe protocol of this Preferred Reporting Items of Systematic Reviews and Meta‐Analyses (PRISMA) 2020‐compliant systematic review was registered in PROSPERO (CRD42021252214). A literature search was conducted to identify articles that met the pre‐established eligibility criteria. Data of interest, with an emphasis on outcome measures, were extracted. For each outcome, specific methods and timing of assessment were described in detail. Following a critical qualitative analysis of the data, outcome measures were categorized. Primary outcomes were identified, and the frequency of reporting in the selected articles was calculated. Additionally, risk‐of‐bias assessments were performed for individual articles and primary outcomes.ResultsNinety‐two articles, of which 39 reported randomized controlled trials (RCTs), 20 non‐RCTs, and 33 case series studies, were selected. Outcome measures were categorized into either investigator‐evaluated outcome measures (i.e., clinical, digital imaging, aesthetic, histological, biomarker, and safety) or patient‐reported outcome measures (PROMs). Clinical outcomes were the most frequently reported type of outcome. Considering all categories, the most frequently reported primary outcomes were facial mucosa thickness assessed with clinical methods (22.83%), facial keratinized mucosa width assessed with clinical methods (19.57%), facial mucosal margin position/recession assessed with clinical methods (18.48%), facial mucosa thickness assessed with digital imaging methods (11.96%), facial soft tissue volume assessed with digital imaging methods (9.78%), and supracrestal tissue height assessed with clinical methods (9.78%). No distinguishable patterns of association between specific types or quality (level of bias) of clinical studies and the choice of primary outcomes were observed.ConclusionsClinical research on peri‐implant soft tissue augmentation has progressively increased in the last 10 years. Although clinical outcome measures were the most frequently reported outcomes in the selected literature, trends in the field are indicative of a shift from traditional clinical assessment methods to the use of digital technologies. PROMs were generally under‐reported but should be considered an integral methodological component in future clinical studies.
Cosmetic dermatology training perspectives during residency: A survey‐based report from Jordan
Authors: Seetan Khaled , Jarrar Bashar , Aldebie Asem , Omari Rami , Eldos Batool , Alsharei Adel 
Published: January 2022

AbstractBackgroundThere has been an evident increase in the number of cosmetic dermatologic procedures performed by dermatologists. Those procedures vary from a simple office‐based one to more complex procedures requiring general anesthesia. Therefore, it is essential to assess the adequacy of cosmetic dermatology training among dermatology residents to meet patients’ expectations.AimWe sought to assess dermatology residents’ educational exposure to cosmetic dermatology and identify the practices and educational gaps of esthetic dermatology residency programs in Jordan.MethodsAn online cross‐sectional study targeted almost all dermatology residents in Jordan from April to June 2021. Forty‐two dermatology residents completed an English online questionnaire that involved sociodemographic data, the resident's educational exposure to cosmetic dermatology, and the resident's opinion regarding the training programs.ResultsOut of the 42 participants, 16 (38.1%) were males, and 26 (61.9%) were females. More than half (54.8%) of the participants reported that cosmetic procedures were done in the department they are attending. The majority (64.3%) did not attend cosmetic training or procedures. The majority strongly agree that hands‐on training is the most beneficial way of cosmetic residency training (88.1%). More than 85% believe that cosmetic dermatology training should be practical and that final‐year residents should perform cosmetic procedures independently. Only 2.4% and 4.8% of the residents were very satisfied or satisfied, respectively, with the current level of cosmetic procedural training.ConclusionThe dermatology residents in Jordan are dissatisfied regarding the current level of cosmetic procedural training. Therefore, infrastructure must be improved; educational training quality must be improved by providing theoretical and practical education in clinics.