bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges to the Europeanisation of work-care policies in the Western Balkans
Authors: Dobrotić Ivana 
Published: August 2022

AbstractThis article explores work-care policy development in Western Balkans, focusing on a critical assessment of the potential of the European Union’s policy framework to (re)shape the policies adopted in Western Balkans and boost gender equality in employment and care. Two policy measures at the centre of the European agenda are in focus: parenting leaves and early childhood education and care. The EU’s employment-oriented policy framework has met underdeveloped childcare services network and mother-centred and stratifying leave policies in Western Balkans, providing ample space for improvements regarding gender imbalance in care and employment. While the EU policy framework may provide an important push factor towards introducing gender-equalising policies in Western Balkans, it can also bring minimum adjustments. The EU’s ambiguous work-care policy framework, weak legitimacy of gender equality agenda and weak fiscal capacities in Western Balkans, and uncertainties about EU membership prospects may hamper progress towards more inclusive and gender-equal work-care policies.
The impact of increasing the availability of lower energy foods for home delivery and socio-economic position: a randomised control trial examining effects on meal energy intake and later energy intake
Authors: Langfield Tess , Jones Andrew , Robinson Eric 
Published: August 2022

AbstractIncreasing the availability of lower energy food options is a promising public health approach. However, it is unclear the extent to which availability interventions may result in consumers later ‘compensating’ for reductions in energy intake caused by selecting lower energy food options and to what extent these effects may differ based on socio-economic position (SEP). Our objective was to examine the impact of increasing availability of lower energy meal options on immediate meal energy intake and subsequent energy intake in participants of higher v. lower SEP. In a within-subjects design, seventy-seven UK adults ordered meals from a supermarket ready meal menu with standard (30 %) and increased (70 %) availability of lower energy options. The meals were delivered to be consumed at home, with meal intake measured using the Digital Photography of Foods Method. Post-meal compensation was measured using food diaries to determine self-reported energy intake after the meal and the next day. Participants consumed significantly less energy (196 kcal (820 kJ), 95 % CI 138, 252) from the menu with increased availability of lower energy options v. the standard availability menu (P < 0·001). There was no statistically significant evidence that this reduction in energy intake was substantially compensated for (33 % compensated, P = 0·57). The effects of increasing availability of lower energy food items were similar in participants from lower and higher SEP. Increasing the availability of lower energy food options is likely to be an effective and equitable approach to reducing energy intake which may contribute to improving diet and population health.
Effect of combining organic manure and inorganic fertilisers on maize–bush bean intercropping
Authors: Ndengu Gift , Mponela Powell , Chataika Barthlomew , Desta Lulseged Tamene , Chirwa Rowland , Sileshi Gudeta G. 
Published: August 2022

SummaryIn sub-Saharan Africa (SSA), farmers intercrop common beans with maize but apply inorganic or organic fertilisers targeting only maize. Effects of this practice on bush bean yield have not been fully evaluated with respect to input use and compatibility when intercropped with maize. An on-farm trial managed by smallholder community members was conducted to assess the influence of various soil fertility management options and cropping systems on the yield of two bush bean genotypes (SER45 and SER83) in two agro-ecological zones of Malawi. The farmer-managed trials were laid out in split-plot design, with the bean genotypes as main plots and a combination of the soil fertility management options (i.e., no input, manure, fertiliser and fertiliser + manure) and cropping systems (i.e., sole crop and intercrop) as subplots. The trials were affected by terminal drought and dry spells, but results show that manure and fertiliser application enhanced the resilience of the drought-tolerant bean genotypes. The genotype SER45 was responsive to manure application in the sole crop, giving a 44.4% yield increase over no-manure application. In sole cropping with fertiliser plus manure, bean yields improved by 40.1% for SER45 and 78.3% for SER83 relative to the no-input control. Although sole cropping had higher bean yields, the treatment with manure and fertiliser had a higher land equivalence ratio for intercrop of 1.54 for SER45 and 1.32 for SER83 over sole cropping. These results show that, under smallholder farmer management, the climate adaptability of bush bean genotypes could be enhanced by the combined application of organic and inorganic fertilisers in maize–bean intercrop. The combined application also enhances whole-farm productivity of the common maize–bean intercrop practice than monocrop, hence is of benefit to most low-input smallholder farmers of SSA.
Geochronology and oxygen fugacity of the pelitic granulite from the Diwani hills, NE Gujarat (NW India)
Authors: Kumar Manish , Prakash D. , Singh C. K. , Yadav M. K. , Tewari S. , Singh Pradip K. , Mahanta B. 
Published: August 2022

AbstractThe Diwani hills are located SE of Balaram–Abu Road in the Banaskantha district of north Gujarat. The crystalline rocks of the Diwani hill area are a diverse assemblage of Precambrian metamorphic and igneous rocks. These rocks are petrologically more complex and date back to the Aravallis or earlier. The mineralogical assemblages such as grt–sp–opx–qz of these rocks indicate their origin in anhydrous or dry conditions, implying metamorphism under pyroxene granulite facies. These granulitic rocks were subjected to Delhi orogenic deformation and were later intruded by the Erinpura granite. Textural and microstructural relationships, mineral chemistry, P–T–X pseudosection modelling and the oxidation state of pelitic granulites from the Diwani hill area of north Gujarat are all part of the current approach. The winTWQ program and pseudosection modelling in the NCKFMASHTO model system utilizing Perple_X software were used to restrict the P–T evolution of these pelitic granulites. The unification of these estimates shows that the pelitic granulites reached their pressure and temperature maxima at 8.6 kbar and 770 °C, respectively. The oxygen fugacity (log fO2) versus temperature computations at 6.2 kbar revealed log fO2–T values of −13.0 and 765 °C, respectively. The electron microprobe dating of monazite grains separated from the granulites of the Diwani hills yields ages ranging from 769 Ma to 855 Ma. The electron microprobe dating presented here from the Diwani hills provides evidence for a Neoproterozoic (Tonian) metamorphic event in the Aravalli–Delhi Mobile Belt.
The Politics of the Social Biographical Approach to Working-Class Leaders
Authors: Nolan Melanie 
Published: August 2022

AbstractIn this paper, I consider John French's biography,Lula and His Politics of Cunning: From Metalworker to President of Brazil(2020). French discusses his methodology, which he characterizes as “a social biographical approach”. I argue that this methodology is already in historians’ toolkit. Historians writing biography seem to start with first premises rather than building on what went before. I thus contextualize the methodology, situating French's biography of Lula within more general shifts in approaches to biography.
Civilian moral injury: associations with trauma type and high-frequency heart rate variability in two trauma-exposed community-based samples
Authors: Lathan Emma C. , Powers Abigail , Kottakis Anna , Guelfo Alfonsina , Siegle Greg J. , Turner Jessica A. , Turner Matthew D. , Yakkanti Vijwala , Jain Jahnvi , Mekawi Yara , Teer Andrew P. , Currier Joseph M. , Fani Negar 
Published: August 2022

AbstractBackgroundMoral injury exposure (MIE) and distress (MID) may indirectly affect the relationship between trauma exposure and alterations in autonomic regulation [assessed via high-frequency heart rate variability (hfHRV)] in civilians, but this has not been tested in prior research. We conducted two exploratory studies to examine trauma types' associations with MIE and MID among civilian medical patients (Study 1) and explore how these facets may indirectly affect the relationship between trauma type and hfHRV among civilians seeking mental health services (Study 2).MethodsParticipants recruited from a public hospital and/or community advertisements (Study 1, n = 72, 87.5% Black, 83.3% women; Study 2, n = 46, 71.7% Black, 97.8% women) completed measures assessing trauma type, MIE, and MID. In Study 1, trauma types that emerged as significant correlates of MIE and MID were entered into separate linear regression analyses. Trauma types identified were included as predictors in indirect effects models with MIE or MID as the mediator and resting hfHRV (assayed via electrocardiography) as the outcome.ResultsChildhood sexual abuse emerged as the only significant predictor of MIE, b = 0.38, p < 0.001; childhood sexual abuse, b = 0.26, p < 0.05, and adulthood sexual assault, b = 0.23, p < 0.05 were significant predictors of MID. Participants with greater MIE and MID demonstrated lower hfHRV. Adulthood sexual assault showed an indirect effect on hfHRV through MID, B = −0.10, s.e. = 0.06, 95%CI (−0.232 to −0.005).ConclusionsMoral injury was uniquely associated with sexual violence and lower hfHRV in civilians. Data highlight moral injury as a pathway through which autonomic dysregulation may emerge and its salience for trauma treatment selection.
A multi-criteria decision analysis on the value of nintedanib for interstitial lung diseases
Authors: Zozaya Néboa , Arrizubieta Basterrechea Maria Iciar , Bollo Elena , Castellví Iván , Espín Jaime , Ortego Norberto , Poveda-Andrés José Luis , Rodríguez Portal José Antonio , Rivero Agustín , Marcos-Rodríguez José Antonio , Verde Luis 
Published: August 2022

Abstract

Objectives
Our aim was to assess the value of nintedanib for non-idiopathic progressive fibrosing interstitial lung disease (non-IPF PF-ILD) and systemic sclerosis-associated ILD (SSc-ILD) in the Spanish context, using a multi-criteria decision analysis (MCDA).

Methods
Following an adaptation of the Evidence and Value: Impact on DEcision Making (EVIDEM) MCDA methodology, the estimated value of nintedanib was obtained by means of an additive linear model that combined individual weights (100-points distribution) of criteria with the individual scoring of nintedanib in each criterion for every indication, assigned by a multidisciplinary committee of twelve clinicians, patients, pharmacists, and decision-makers. To assess the reproducibility, an alternative weighting method was applied, as well as a re-test of weights and scores at a different moment of time.

Results
The experts committee recognized nintedanib as an intervention with a positive value contribution in comparison to placebo for the treatment of non-IPF PF-ILD (0.50 ± 0.16, on a scale from −1 to 1) and SSc-ILD (0.40 ± 0.12), diseases which were considered as very severe and with high unmet needs. The drug was perceived as a treatment that provides an added therapeutic benefit for patients (0.06–0.07), given its proven clinical efficacy (0.05–0.06), slight improvements in patient-reported outcomes (0.01–0.02), and similar safety profile than placebo (−0.04–0.00), which will likely be positioned as a recommended therapy in the next clinical practice guidelines updates.

Conclusions
Under this increasingly used methodology, nintedanib has shown to provide a positive value estimate for non-IPF PF-ILD and SSc-ILD when compared to placebo in Spain.
International order and racial capitalism: The standardization of ‘free labour’ exploitation in international law
Authors: Hammoudi Ali 
Published: August 2022

AbstractThe ‘question of labour’ and its exploitation in the Third World has not been given ample consideration by contemporary international legal scholars in their historical examinations of the making of the international order. This article revisits the history of the interwar institutions of the League of Nations, particularly the International Labour Organization (ILO), to argue that international law reformulated imperialism through its re-articulation of labour relations, beginning with its quest to suppress slavery and ultimately regulate forced labour in Africa. International institutions contributed to the valorization of ‘free wage labour’ in Africa and the Third World through its international ‘native labour’ policies, the development of international labour standards, and especially the passing of the 1930 Forced Labour Convention. The article argues that international institutions safeguarded the processes of capitalist racial/colonial accumulation and labour exploitation by ideologically dis-embedding the violence of slavery and forced labour from ‘free wage labour’, veiling the structural unity and totality of the international legal order with racial capitalism. Drawing on the ‘Black radical/internationalist tradition’, I propose an expansive critique of the international order as a form of ‘enslavement’ to the structures of capitalism, so as to adequately expose international law’s structural embeddedness with labour exploitation, white supremacy, and racial capitalism.
Tricuspid valve repair with papillary muscle approximation for congenital tricuspid valve regurgitation due to tricuspid valve dysplasia
Authors: Maeda Toshi , Ikeda Tadashi , Yoshizawa Kosuke 
Published: August 2022

AbstractWe experienced a case of a 1-year-old female with congenital tricuspid valve regurgitation caused by tricuspid valve dysplasia. The anterior and septal leaflets were particularly dysplastic, and leaflet tethering was observed. The anterior papillary muscle was approximated to the interventricular septum, and a commissural edge-to-edge suture was inserted on the anteroseptal commissure. Tricuspid valve regurgitation improved to be trivial after surgery and has not worsened 1 year later. Papillary muscle approximation could be one of the feasible reparative techniques for congenital tricuspid valve regurgitation.
From unified phrase representation to bilingual phrase alignment in an unsupervised manner
Authors: Liu Jingshu , Morin Emmanuel , Peña Saldarriaga Sebastian , Lark Joseph 
Published: August 2022

AbstractSignificant advances have been achieved in bilingual word-level alignment, yet the challenge remains for phrase-level alignment. Moreover, the need for parallel data is a critical drawback for the alignment task. This work proposes a system that alleviates these two problems: a unified phrase representation model using cross-lingual word embeddings as input and an unsupervised training algorithm inspired by recent works on neural machine translation. The system consists of a sequence-to-sequence architecture where a short sequence encoder constructs cross-lingual representations of phrases of any length, then an LSTM network decodes them w.r.t their contexts. After training with comparable corpora and existing key phrase extraction, our encoder provides cross-lingual phrase representations that can be compared without further transformation. Experiments on five data sets show that our method obtains state-of-the-art results on the bilingual phrase alignment task and improves the results of different length phrase alignment by a mean of 8.8 points in MAP.
Financial shocks and the relative dynamics of tangible and intangible investment: Evidence from the euro area
Authors: Gareis Johannes , Mayer Eric 
Published: August 2022

AbstractWe develop an extended real business cycle model with financially constrained firms and non-pledgeable intangible capital. Based on a model-consistent series for firms’ borrowing conditions, we find, within a structural vector autoregression framework, that, in response to an adverse financial shock, tangible investment falls more than intangible investment. This positive co-movement between tangible and intangible investment as well as the relative resilience of intangible investment pose a challenge for the theoretical model. We show that investment-specific adjustment costs help in reconciling the model with the observed empirical evidence. The estimation of the theoretical model using a Bayesian limited information approach yields support for the presence of much larger adjustment costs for intangible investment than for tangible investment.
Inhibition of the m6A reader IGF2BP2 as a strategy against T-cell acute lymphoblastic leukemia
Authors: Feng Panpan , Chen Dawei , Wang Xia , Li Yanxia , Li Zhenyu , Li Boya , Zhang Yupeng , Li Wei , Zhang Jingru , Ye Jingjing , Zhao Baobing , Li Jingxin , Ji Chunyan 
Published: August 2022

AbstractT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignant leukemia with extremely limited treatment for relapsed patients. N6‐methyladenosine (m6A) reader insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) participates in the initiation and growth of cancers by communicating with various targets. Here, we found IGF2BP2 was highly expressed in T-ALL. Gain and loss of IGF2BP2 demonstrated IGF2BP2 was essential for T-ALL cell proliferation in vitro and loss of IGF2BP2 prolonged animal survival in a human T-ALL xenograft model. Mechanistically, IGF2BP2 directly bound to T-ALL oncogene NOTCH1 via an m6A dependent manner. Furthermore, we identified a small-molecule IGF2BP2 inhibitor JX5 and treatment of T-ALL with JX5 showed similar functions as knockdown of IGF2BP2. These findings not only shed light on the role of IGF2BP2 in T-ALL, but also provide an alternative γ‑Secretase inhibitors (GSI) therapy to treat T-ALL.
High-resolution structural variant profiling of myelodysplastic syndromes by optical genome mapping uncovers cryptic aberrations of prognostic and therapeutic significance
Authors: Yang Hui , Garcia-Manero Guillermo , Sasaki Koji , Montalban-Bravo Guillermo , Tang Zhenya , Wei Yue , Kadia Tapan , Chien Kelly , Rush Diana , Nguyen Ha , Kalia Awdesh , Nimmakayalu Manjunath , Bueso-Ramos Carlos , Kantarjian Hagop , Medeiros L. Jeffrey , Luthra Rajyalakshmi , Kanagal-Shamanna Rashmi 
Published: August 2022

AbstractChromosome banding analysis (CBA) remains the standard-of-care for structural variant (SV) assessment in MDS. Optical genome mapping (OGM) is a novel, non-sequencing-based technique for high-resolution genome-wide SV profiling (SVP). We explored the clinical value of SVP by OGM in 101 consecutive, newly diagnosed MDS patients from a single-center, who underwent standard-of-care cytogenetic and targeted NGS studies. OGM detected 383 clinically significant, recurrent and novel SVs. Of these, 224 (51%) SVs, seen across 34% of patients, were cryptic by CBA (included rearrangements involving MECOM, NUP98::PRRX2, KMT2A partial tandem duplications among others). SVP decreased the proportion of normal karyotype by 16%, identified complex genomes (17%), chromothripsis (6%) and generated informative results in both patients with insufficient metaphases. Precise gene/exon-level mapping allowed assessment of clinically relevant biomarkers (TP53 allele status, KMT2A-PTD) without additional testing. SV data was complementary to NGS. When applied in retrospect, OGM results changed the comprehensive cytogenetic scoring system (CCSS) and R-IPSS risk-groups in 21% and 17% patients respectively with an improved prediction of prognosis. By multivariate analysis, CCSS by OGM only (not CBA), TP53 mutation and BM blasts independently predicted survival. This is the first and largest study reporting the value of combined SVP and NGS for MDS prognostication.
Bound vortex light in an emulated topological defect in photonic lattices
Authors: Sheng Chong , Wang Yao , Chang Yijun , Wang Huiming , Lu Yongheng , Yang Yingyue , Zhu Shining , Jin Xianmin , Liu Hui 
Published: August 2022

AbstractTopology have prevailed in a variety of branches of physics. And topological defects in cosmology are speculated akin to dislocation or disclination in solids or liquid crystals. With the development of classical and quantum simulation, such speculative topological defects are well-emulated in a variety of condensed matter systems. Especially, the underlying theoretical foundations can be extensively applied to realize novel optical applications. Here, with the aid of transformation optics, we experimentally demonstrated bound vortex light on optical chips by simulating gauge fields of topological linear defects in cosmology through position-dependent coupling coefficients in a deformed photonic graphene. Furthermore, these types of photonic lattices inspired by topological linear defects can simultaneously generate and transport optical vortices, and even can control the orbital angular momentum of photons on integrated optical chips.
Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells
Authors: You Linhao , Yu Pan-Pan , Dong Tianyu , Guo Wenhuan , Chang Shiyang , Zheng Bingjie , Ci Yunzhe , Wang Fudi , Yu Peng , Gao Guofen , Chang Yan-Zhong 
Published: August 2022

AbstractBrain iron dysregulation associated with aging is closely related to motor and cognitive impairments in neurodegenerative diseases. The regulation of iron traffic at the blood-brain barrier (BBB) is crucial to maintain brain iron homeostasis. However, the specific mechanism has not been clarified in detail. Using various conditional gene knockout and overexpression mice, as well as cell co-culture of astrocyte and bEND.3 in the transwell, we found that astrocyte hepcidin knockdown increased the expression of ferroportin 1 (FPN1) of brain microvascular endothelial cells (BMVECs), and that it also induced brain iron overload and cognitive decline in mice. Moreover, BMVECs FPN1 knockout decreased iron contents in the cortex and hippocampus. Furthermore, hepcidin regulates the level of FPN1 of BMVECs with conditional gene overexpression in vivo and in vitro. Our results revealed that astrocytes responded to the intracellular high iron level and increased the secretion of hepcidin, which in turn diminished iron uptake at BBB from circulation through directly regulating FPN1 of BMVECs. Our results demonstrate that FPN1 of BMVECs is a gateway for iron transport into the brain from circulation, and the controller of this gateway is hepcidin secreted by astrocyte at its endfeet through physical contact with BMVECs. This regulation is indeed the major checkpoint for iron transport from the blood circulation to the brain. This study delineates the pathway and regulation of iron entry into the brain, providing potential therapeutic targets for iron dysregulation-related neurological diseases.