bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cluster Randomised Trials - Ivermectin Repurposing for Covid-19 Treatment of Outpatients with Mild Disease in Primary Health Care Centers
Authors: Chahla Rossana Elena , Ruiz Luis Medina , Mena Teresa , Brepe Yolanda , Terranova Paola , Ortega Eugenia Silvana , Barrenechea Guillermo Gabriel , Goroso Daniel Gustavo , de Bruno María de los Ángeles Peral 
Published: March 2022

Abstract
Background: The emergence of COVID-19 requires alternative treatments. This study aims to evaluate the therapeutic intervention with ivermectin in outpatients with COVID-19 mild disease, to increase discharge and prevent the progression to moderate or severe disease. Methods: Randomized Trial in an overall ratio 1:1, n = 254. The subjects were divided into experimental (EG: n = 110) and control groups placebo (CG: n = 144). The EG received ivermectin orally 0.6 mg/kg weight in two doses. All participants were by physical examination COVID-19 diagnosed with negative RT-PCR at the beginning and the end of protocol. Differences between the variables were determined using the Chi-square test (p<0.05). The contagion risk (Odds Ratio) was calculated using software STATA. Results: Both groups were similar in age, sex, and comorbidities. A significant reduction in the percentage of participants with symptoms (PPS) was observed in the EG and CG when the clinical evaluation of symptoms was performed from 5th to 9th (p= 0·0005). When the clinical evaluation was performed from 10th to 14th day there was no significant difference. A higher proportion of outpatient discharge was observed in EG (98·2%) vs. CG (86·1%) (p-Value = 0·0007). EG showed 8 times more chance of receiving discharge than CG (OR 8·71, 95% CI: 1·99 -38·12, p = 0·004). The treatment effect with ivermectin to obtain discharge from outpatient care was analyzed by the logistic regression. Then, the chance to obtain outpatient discharge was independent of variables sex, age, and comorbidities. Conclusion: Treatment with ivermectin in outpatients care with mild disease of COVID-19 managed to slightly reduce PPS. The treatment with ivermectin could significantly prevent the evolution to serious stages since the EG did not present any patient with referral to critical hospitalization. Retrospective Clinical Registration: ClinicalTrial.gov Identifier NCT04784481; Trial registrationdate: 03-05-2021. Last updated: 04-26-2021.
An Interpretive Descriptive Approach to Understanding Osteoporosis Management from the Perspective of People with Osteoporosis
Authors: Ziebart Christina , MacDermid Joy , Furtado Rochelle , Szekeres Mike , Suh Nina , Khan Aliya 
Published: March 2022

Abstract
Background: Adherence to both non-pharmacological and pharmacological fracture prevention interventions is often low in people with osteoporosis. Understanding how patients acquire information about osteoporosis management is important for understanding both the initial decision-making and ongoing adherence. This study explored the narrative of people living with osteoporosis and their personal experience getting information about their osteoporosis management. Methods: An interpretive descriptive method was used for this qualitative study. In-depth interviews were conducted with 13 Canadian participants (age range 51-90) who knew that they had osteoporosis or osteopenia. Participants were asked to participate in one-on-one interviews to address the type of health professionals providing osteoporosis management advice focusing specifically on advice received about exercise, nutrition, and falls prevention. Interviews were transcribed verbatim and coded sentence-by-sentence. Results: People with osteoporosis rely on physicians for advice related to pharmacological treatment needs, and other health professionals for non-pharmacological needs such as exercise advice, nutrition advice, and falls prevention advice. People value non-professionals, such as family members and close friends, who may or may not have osteoporosis, to discuss or corroborate health professional advice, or to validate their belief system. Conclusion: Training patients to more effectively engage in conversations with their healthcare providers may be a strategy to improve the quality of communication and its translation into adherence to best practices in managing osteoporosis.
Different Angular Kyphosis Locations Have Different Relative Positions of Aorta to Spine in Patients with Pott's Deformity
Authors: Jiang Heng , Liao Taotao , Lu Zhengyu , Wang Ce , Gao Rui , Ma Jun , Zhou Xuhui , Zhao Jianquan 
Published: March 2022

Abstract
Background. The position of the aorta relative to the spine in kyphosis secondary to ankylosing spondylitis is little understood. The purpose of this study was to investigate the anatomic relationship between the aorta and the spine in patients with Pott's deformity and to compare it with the normal people.Methods. Seventy-six patients with Pott's deformity (Group TB) and seventy-two age- and sex-matched patients with a normal spine (group NC) were enrolled in this study. The relative position of aorta to the spine was evaluated from T4 to L4 on the computed tomographic angiography scans for controls and at the apex level for TB patient, and was classified into 4 kinds of degrees. Results. The left pedicle-aorta angle in group TB was significantly larger than that in group NC at the T6-L3 levels. Group TB exhibited significantly smaller left pedicle-aorta distance, pedicular line-aorta distance and vertebra/rib-aorta distance than those in group NC at the T5-T10 levels, but bigger at the L1-3 levels. Patients with grade 3 and 4 aorta had more segments involved compared with those with grade 1 aorta. Patients with grade 2, 3, and 4 aorta showed larger kyphotic angles than those with grade 1.Conclusions. Patients whose morbid segments involved only thoracic vertebrae presented with an “Ω” shaped aorta in sagittal plane, and 4 different kinds of degrees of aorta relative to the vertebra/rib in axial plane. Patients whose morbid segments covered lumbar vertebrae presented with an “M” shaped aorta in sagittal plane, and the aorta shifted further from apex vertebra but was located in close proximity to the vertebral body at levels above and below the osteotomy levels in axial plane.
Hospice Care Providers’ Knowledge, Attitudes And Practices In China: A Cross-Sectional Study
Authors: Shu Zhiqun , Jing Limei 
Published: March 2022

Abstract
Background: In recently years, China has been growing awareness about the hospice service movement although hospice care was Initially introduced 30 years ago. Hospice care providers’ knowledge, attitudes, self-efficiency, and practices status in China should be investigated. This study aims to survey the general actuality of hospice care providers’ knowledge, attitudes, and practices of hospice care (KAPHC) in five cities in China, and explore relevant influencing factors.Method: Relying on our KAPHC scale, we randomly surveyed 3647 valid health care providers in five sampled cities of China in 2019, which respectively represent the north, northeast, east, central, and southwest area. In each city, 14 institutions were selected and 50 health providers were surveyed in each institution. Increment of voluntary participation was accepted. The scaling outcomes were compared among each sampled city-groups with Chi-square test or ANOVA. Multiple correspondence analyses were also performed for further results.Results: Of all, 41.46% providers had real experience in providing hospice care, and 58.68% confirmed willingness of providing. The overall knowledge correct rate was 57.13%. The average scores of threats, benefits, barriers, subjective norms, confidence, and self-report behaviour items were 15.40, 41.56, 16.75, 15.65, 41.56, and 38.61. Providers from eastern China, willing to provide hospice care, or experienced death witness in providing hospice care, proved better score in knowledge, threats, benefits, barriers, subjective norms, confidence, and self-report behaviour (P<0.05).Conclusions: The investigation reflected urgent need for systematic training of professional knowledge and skills on hospice care for health care providers. Governments’ attention and policy measures are crucial as most Chinese hospice care providers practiced as “organization actors”. More attention was need on balanced development of different areas.
Naringenin protects hepato-renal tissues against antituberculosis drugs induced toxic manifestations by modulating IL-6, IGF-1, CYP2E1, biochemical and ultra-structural integrity
Authors: Sahu Nisha , Rakshit Samrat , Nirala Satendra Kumar , Bhadauria Monika 
Published: March 2022

Abstract
The antituberculosis drugs (ATDs), isoniazid, rifampicin, pyrazinamide and ethambutol prompt extreme hepatic and renal damage during treatment of tuberculosis. The present study aimed to investigate protective potential of naringenin against ATDs induced hepato-renal injury. Rats were administered with ATDs orally for 8 weeks (3 days/week) followed by naringenin at three different doses (10, 20 and 40 mg/kg) conjointly for 8 weeks (3 days/week alternately to ATDs administration) and silymarin (50 mg/kg) as positive control. Exposure to ATDs caused significant increase in IL-6, triglycerides, cholesterol, bilirubin whereas depletion in IGF-1, albumin and glucose in serum. Endogenous antioxidants GR, GPx and G-6-PDH were diminished in liver and kidney tissues with parallel increase in triglycerides, cholesterol, microsomal LPO and aniline hydroxylase (CYP2E1 enzyme). Ultra-structural observations of liver and kidney showed marked deviation in plasma membranes of various cellular and sub-cellular organelles after 8 weeks of exposure to ATDs. Conjoint treatment of naringenin counteracted ATDs induced toxic manifestations by regulating IL-6, IGF-1, CYP2E1, biochemical and ultra-structural integrity in a dose dependent manner. Naringenin has excellent potential to protect ATDs induced hepato-renal injury by altering oxidative stress, modulation of antioxidant enzymes, serum cytokines and ultra-structural changes.
Analysis of the most effective cluster strategies implemented in circumpolar regions
Authors: Хаценко Е.С. 
Published: March 2022

Представленная статья посвящена анализу функционирования и развития региональных отраслевых арктических кластеров, их влиянию на пространственное развитие Арктической зоны, осуществлен анализ направлений реализации региональной кластерной стратегии развития субъектов, осуществлена оценка кластерного потенциала отраслей экономики субъектов Арктической зоны.
The presented article is devoted to the analysis of the functioning and development of regional sectoral Arctic clusters, their impact on the spatial development of the Arctic zone, the analysis of the directions of implementation of the regional cluster strategy for the development of the subjects, the assessment of the cluster potential of the economic sectors of the subjects of the Arctic zone.
Primary accounting documents as a basis for ensuring the economic security of small and medium-sized businesses
Authors: Банк С.В. , Вакуленко В.Ф. 
Published: March 2022

Обеспечение экономической безопасности - первостепенное условие постоянства и результативности деятельности компании. В современной реальности, когда процветает недобросовестная конкуренция, популяризирована коррупция, распространен уход деятельности в сектор теневой экономики, важность обеспечения экономической безопасности на должном уровне возрастает. Способы, определенные законодателем, давая возможность целесообразно управлять компанией, в свою очередь, представляют собой угрозу для экономической безопасности. Компания самостоятельно принимает решение о применении элементов бухгалтерского учета, о том, что включает в себя учетная политика, что обуславливают процедуры внутреннего контроля.
Ensuring economic security is the primary condition for the consistency and effectiveness of the company's activities. In modern reality, when unfair competition is flourishing, corruption is popularized, activities are widespread in the shadow economy, the importance of ensuring economic security at the proper level increases. The ways defined by the legislator, making it possible to expediently manage the company, in turn, pose a threat to economic security. The company independently decides on the application of accounting elements, on what the accounting policy includes, and what determines the internal control procedures.
On the question of the logical organization of the methodology of statistics
Authors: Минашкин В.Г. , Коротков А.В. 
Published: March 2022

Статья содержит развитие модели логической организации методологии статистики в части актуализации представления о структуре методологии в виде совокупности разделов и их наполнения конкретными инструментами. В учебной литературе по статистике содержится богатый и взаимодополняющий материал, всесторонне раскрывающий категорию методологии статистики, который позволяет, во-первых, обобщить известные результаты и, во-вторых, развить представление о содержании и структуре методологии статистики с тем, чтобы данная тема приобрела более завершенный вид.
The article contains the development of the model of the logical organization of the methodology of statistics in terms of updating the concept of the structure of the methodology in the form of a set of sections and their filling with specific tools. The educational literature on statistics contains rich and complementary material that comprehensively reveals the category of statistical methodology, which allows, firstly, to generalize the known results and, secondly, to develop an understanding of the content and structure of statistical methodology so that this topic becomes more complete. view.
Financial analysis in the system of tax control
Authors: Банк С.В. 
Published: March 2022

Финансовый анализ как компонент целесообразного налогового контроля - это исследование единства налогов и сборов, которые уплачивает субъект предпринимательства в различные временные периоды, оценка налогового положения, дающее возможность минимизировать размер платежей. С методической точки зрения такой анализ проводится как комплексная оценка, которая объединяет определение аналитических задач, установление налоговой нагрузки, исследование соответствующих платежей, отбор путей оптимизации налогов и определение результативности от них. Расчетные данные с использование способов прогнозирования выступают одним из значимых оценочных компонентов в области исследование степени налоговых платежей, потенциальных финансовых последствий. Кроме того, все большую актуальность обретает использование информационно-компьютерного обеспечения при отборе оптимальных аналитических решений.
Financial analysis as a component of expedient tax control is a study of the unity of taxes and fees that a business entity pays in different time periods, an assessment of the tax situation, which makes it possible to minimize the amount of payments. From a methodological point of view, such an analysis is carried out as a comprehensive assessment that combines the definition of analytical tasks, the establishment of the tax burden, the study of relevant payments, the selection of ways to optimize taxes and determine the effectiveness of them. Estimated data using forecasting methods are one of the most significant evaluative components in the study of the degree of tax payments, potential financial consequences. In addition, the use of information and computer support in the selection of optimal analytical solutions is becoming increasingly important.
Analysis of prospects for the development of regional banks
Authors: Волкова Е.К. 
Published: March 2022

В статье анализируются аспекты, влияющие на деятельность региональных банков (на примере российской банковской системы). Актуальность темы исследования обусловлена наличием проблемы сохранения конкурентоспособности региональных банков на фоне повышения уровня концентрации банковского сектора, усиления роли крупных банков в глобальной финансовой экономике и влияния выраженных тенденций масштабной цифровизации банковского сектора. Целью исследования является обоснование направлений и перспектив развития региональных банков.
The article analyzes the aspects affecting the activities of regional banks (using the example of the Russian banking system). The relevance of the research topic is due to the presence of the problem of maintaining the competitiveness of regional banks against the background of an increase in the concentration of the banking sector, the strengthening of the role of large banks in the global financial economy and the influence of pronounced trends in large-scale digitalization of the banking sector. The purpose of the study is to substantiate the directions and prospects for the development of regional banks.
The Importance of Fincult: How to handle money during the SOVID-19 pandemic properly?
Authors: Савинова Е.А. , Мельникова В.Г. 
Published: March 2022

В данной статье рассмотрено значение и определены основные задачи и способы привлечения интереса молодого поколения к вопросам бережного, разумного потребления, финансовой грамотности, особо подчеркивается актуальность повышения среди обучающихся уровня финансовой культуры во времена пандемии новой коронавирусной инфекции СОVID-19. В рамках работы проведен анализ текущего уровня финансовой грамотности населения, выявлены проблемы управления личными финансами в контексте пандемии и кризиса, сформированы основные рекомендации в области финансового просвещения.
This article examines the importance and identifies the main tasks and ways to attract the interest of the younger generation to the issues of careful, reasonable consumption, financial literacy, emphasizes the relevance of raising the level of financial culture among students during the pandemic of the coronavirus COVID-19. As part of the work, an analysis of the financial literacy of the population to date was carried out, the problems of managing private financial assets in the current conditions of a pandemic and crisis were identified, and the main recommendations in the field of financial education were formed.
Features of investing in ESG instruments, Russian and foreign experience
Authors: Стрельников Е.В. 
Published: March 2022

В статье проанализирован мировой опыт к ESG-инвестированию, а также представлена характеристика подходов разных стран к финансовой политике в отношении развития и расширения рынка зеленых инвестиций. В рамках постановки цели и задач исследования определено рассмотрение возможностей развития рынка зеленых финансов в России на основе анализа европейского подхода и выявления конкретно российских особенностей экологического инвестирования. В особенности рассмотрен подход к зеленому инвестированию на региональном уровне. Результаты исследования могут быть использованы Банком России в качестве практически реализуемой меры по расширению российского рынка зеленых облигаций в рамках финансирования региональных проектов.
The article analyzes the world experience in ESG investment, and also presents a description of the approaches of different countries to financial policy in relation to the development and expansion of the green investment market. Within the framework of setting the goals and objectives of the study, it is determined to consider the possibilities of developing the green finance market in Russia based on the analysis of the European approach and the identification of specifically Russian features of environmental investment. In particular, the approach to green investment at the regional level is considered. The results of the study can be used by the Bank of Russia as a practically feasible measure to expand the Russian green bond market as part of financing regional projects.
The eaeu railway transport: current status and development prospects
Authors: Игнатова О.В. , Алексахина В.Г. 
Published: March 2022

В статье рассматриваются аспекты функционирования железнодорожных систем стран ЕАЭС, анализируются причины сокращения грузооборота. Авторы рассматривают текущее состояние железнодорожного транспорта каждой из стран-участниц, выявляют сильные и слабые стороны отрасли, оценивают возможность взаимной интеграции и увеличения привлекательности магистральных путей сообщения.
The article deals with aspects of the functioning of the railway networks of the EAEU countries. It analyzes the reasons for the reduction in freight turnover. The authors consider the current state of railway transport in each of the participating countries; they identify the strengths and weaknesses of the industry, assess the possibility of mutual integration and increasing the attractiveness of main lines of communication.
The development of the regional economy of Russia in the context of a global pandemic
Authors: Веселовский М.Я. , Вершинин А.А. 
Published: March 2022

В статье рассмотрены современные проблемы экономики, с которыми сталкиваются регионы. Изучены статистические данные по регионам, а также обсуждены данные по государственному долгу в разрезе регионов в условиях пандемии. Авторами проанализированы размеры финансовой помощи со стороны федеральной власти. Сделаны выводы по современному состоянию региональной экономики России и сформулированы предложения для решения существующих проблем.
The article deals with the current economic problems faced by the regions. The statistical data on the regions were studied, as well as the data on the public debt in the context of the regions in the context of the pandemic were discussed. The authors analyzed the amount of financial assistance from the federal government. Conclusions are made on the current state of the regional economy in Russia and proposals for solving existing problems are formulated.
Response to the Covid-19 Pandemic and prospects for restoring of the FX markets in the Eurasian Economic Union
Authors: Мишина В.Ю. , Хомякова Л.И. 
Published: March 2022

Негативное влияние пандемии Covid-19 проявилось во всех сферах экономической жизни, включая валютные рынки стран ЕАЭС. Вместе с тем, проведенный авторами статьи анализ показал готовность валютных рынков к постепенному восстановлению, что стало результатом денежно-кредитной и валютной политики стран ЕАЭС и принятых ими мер по противодействию экономическим последствиям пандемии. Значимым фактором в развитии позитивных тенденций сыграли интеграционные процессы на финансовых рынках стран ЕАЭС, в том числе Интегрированный валютный рынок ЕАЭС. В числе дискуссионных остаются вопросы дальнейшего стимулирования операций в национальных валютах.
The negative impact of the Covid-19 pandemic has manifested itself in all spheres of economic life, including the foreign exchange markets of the EAEU countries. At the same time, the analysis carried out by the authors of the article showed the readiness of the foreign exchange markets for a gradual recovery, which was the result of the monetary policy of the EAEU countries and the measures they took to counter the consequences of the pandemic. The EAEU Integrated Currency Market played a significant factor in the development of positive trends. In addition, the relatively low volatility of national currencies against the Russian ruble contributed to the development of transactions in these currencies. Among the controversial issues are the issues of further stimulation of operations in national currencies.