bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prognostic significance of the Rajan's heart failure risk score for mid-range ejection fraction in patients hospitalized for heart failure
Authors: Yıldız Pınar Özmen 
Published: January 2025

Abstract

INTRODUCTION:
Heart failure with mid-range ejection fraction (HFmrEF) represents a distinct clinical entity with unique prognostic challenges, lacking widely adopted risk scoring tools for predicting mortality and rehospitalization. This study investigates the utility of Rajan's heart failure (R-HF) risk score as a simple and effective stratification tool in this patient population.
MATERIAL AND METHODS
In this retrospective cohort study, 175 HFmrEF patients were stratified by R-HF risk score into four groups: high risk, moderate risk, low risk, and minimal risk. The Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) risk score was calculated for comparison. Receiver operating characteristic (ROC) curve and logistic regression analyses assessed the scores' predictive performance for a composite endpoint of HF-related rehospitalization and all-cause mortality.
RESULTS
The R-HF risk score showed an area under the ROC curve (AUC) of 0.822, suggesting strong predictive accuracy (p < 0.001). An optimal cut-off value of 10.30 achieved a sensitivity of 83.1% and a specificity of 75.0% for predicting HF-related rehospitalization and all-cause mortality. In comparison, the MAGGIC score yielded a lower AUC of 0.633 (p = 0.004).
CONCLUSIONS
The R-HF risk score effectively stratifies HFmrEF patients by risk, outperforming the frequently used MAGGIC score in this study's context. Its simplicity and prognostic reliability make it a valuable tool for managing HFmrEF patients, particularly in reducing HF-related rehospitalization and all-cause mortality (Table 4, Fig. 1, Ref. 18).
Renal Artery Involvement as a Reliable Indicator of Severe Branch Vessel Involvement and Malperfusion in Type A Aortic Dissection
Authors: Huang Ling-chen , Gan Li-xi , Zhang Si-yu , Shao Ze-hua , Sun Yang-xue , Gu Yuan-rui , Qian Xiang-yang , Sun Xiao-gang , Yu Cun-tao , Liu Hong , Guo Hongwei 
Published: January 2025

Abstract

Background: Reliable indicators to assess the severity and extent of type A aortic dissection (TAAD) remain lacking. This study aimed to evaluate the role of renal artery involvement in this context.
Methods: From January 2020 to June 2022, a total of 471 patients with TAAD who underwent open surgical repair were retrospectively analyzed. Based on computed tomography angiography, patients were categorized into two groups: those with renal involvement (RAI, n=289) and those without (non-RAI, n=182). To further validate the results, propensity score matching (PSM) was performed to minimize bias. A multivariate ordered logistic regression model was used to evaluate the association between renal involvement and the number of end-organ malperfusion. The incidence of dialysis dependence was calculated using the Kaplan-Meier method. Cox regression models were utilized to determine factors of overall and mid-term mortality.
Results: The RAI group exhibited more extensive aortic branch involvement (all P<0.05) and required more concomitant branch procedures, with a higher incidence of end-organ malperfusion (P=0.006), as well as increased serious adverse events (P=0.009), which remain consistent after PSM matching. The multivariate ordered logistic regression model indicated that renal involvement was associated with malperfusion [Odds ratio=2.00, 95% confidence interval (CI):1.25-3.27]. Multivariable Cox regression analysis identified renal involvement as an independent risk factor for overall mortality [hazard ratio (HR)=3.48, 95%CI:1.15-10.47, P=0.027] and mid-term mortality (HR=3.42, 95%CI:1.14-10.31, P=0.029). Kaplan-Meier analysis revealed no significant difference in dialysis dependence.
Conclusions: Renal artery involvement signifies more severe aortic branch compromise and malperfusion, and worse prognosis.
Bibliometric Analysis of Breast Cancer Research in Egypt: Trends, Collaborations, and Impact
Authors: Osman Ismail Ragab 
Published: January 2025

Abstract

This paper presents a comprehensive bibliometric analysis of breast cancer research in Egypt, utilizing data from Web of Science (WoS) retrieved on January 1, 2024. Analyzing 2,232 articles published between 1980 and 2023, the study reveals a notable surge in research output and impact in recent years, with 37,927 citations accrued, indicating distinct periods of scholarly influence. Authorship patterns highlight a strong inclination toward collaboration, with multi-authored papers dominating at 90.2%. Leading Egyptian authors such as Rakha, EA, Toss, MS, and El-Shinawi, M, demonstrate significant contributions to the field. Analysis of the co-authorship network uncovers 14 distinct research clusters, reflecting collaborative endeavors within the Egyptian academic community. Notable institutions like Cairo University, Ain Shams University, and Cairo University National Cancer Institute (CUNCI) emerge as pivotal players in driving breast cancer research within the country. Regionally and internationally, collaborations extend to countries such as Saudi Arabia, the United States, and England. Egyptian breast cancer research is disseminated across 759 journals, with preferences for outlets like the "Egyptian Journal of Radiology and Nuclear Medicine" and "Breast Cancer Research and Treatment." The top 10 most cited papers showcase impactful research endeavors across diverse thematic areas. Co-occurrence analyses of authors' keywords provide insights into prevalent themes, including apoptosis, triple-negative breast cancer (TNBC), anticancer therapies, metastasis, and biomarkers. Overall, this bibliometric analysis offers valuable insights for future research directions and healthcare strategies in Egypt's breast cancer landscape.
Factors influencing Frailty in elderly AIDS hospitalized patients in a hospital in south-west China: a cross-sectional study
Authors: Wan Bin , Wu Chuntao , Chen Xueyu , Feng Shiping , Xiao Xuejue , Liu Chunmei , Lyn Chunrong , Zhao Xia 
Published: January 2025

Abstract

Frailty is the main factor leading to functional decline and death in the elderly, and increases the adverse clinical outcomes of elderly AIDS patients. Early identification of reversible frailty factors in elderly AIDS patients and active intervention can delay the frailty and disability of elderly AIDS patients. This study investigated the status and influencing factors of frailty in 219 elderly AIDS hospitalized patients, of whom 161 (73.52%) developed frailty. The results of univariate analysis showed that nutritional status, cognitive status, anxiety, and depression were all related to frailty in elderly AIDS patients, and the differences were statistically significant (P < 0.05). Binary Logistic regression analysis showed that elderly AIDS patients with malnutrition (OR = 0.172, 95%CI: 0.054–0.550, P = 0.003) and moderate anxiety (OR = 6.540, 95%CI: 1.776–24.079, P = 0.005) were more likely to develop frailty. The survey results show that the prevalence of frailty is high among elderly AIDS hospitalized patients in China. We should pay attention to the current situation of frailty among AIDS hospitalized patients and take effective intervention measures as early as possible to delay the occurrence of frailty.
Transmission pathways of Campylobacter jejuni between humans and livestock in rural Ethiopia are highly complex and interdependent
Authors: Singh Nitya , Thystrup Cecilie A.N. , Hassen Bahar Mummed , Bhandari Menuka , Rajashekara Gireesh , Hald Tine M. , Manary Mark J. , McKune Sarah L. , Hassen Jemal Yusuf , Smith Helen L. , Marshall Jonathan C. , French Nigel P. , Havelaar Arie H. 
Published: January 2025

Abstract

Background
Campylobacter jejuni and C. coli are the most common causes of bacterial enteritis worldwide whereas symptomatic and asymptomatic infections are associated with stunting in children in low- and middle-income countries. Little is known about their sources and transmission pathways in low- and middle-income countries, and particularly for infants and young children. We assessed the genomic diversity of C. jejuni in Eastern Ethiopia to determine the attribution of infections in infants under 1 year of age to livestock (chickens, cattle, goats and sheep) and other humans (siblings, mothers).
Results
Among 287 C. jejuni isolates, 48 seven-gene sequence types (STs), including 11 previously unreported STs were identified. Within an ST, the core genome STs of multiple isolates differed in fewer than five alleles. Many of these isolates do not belong to the most common STs reported in high-resource settings, and of the six most common global STs, only ST50 was found in our study area. Isolates from the same infant sample were closely related, while those from consecutive infant samples often displayed different STs, suggesting rapid clearance and new infection. Four different attribution models using different genomic profiling methods, assumptions and estimation methods predicted that chickens are the primary reservoir for infant infections. Infections from chickens are transmitted with or without other humans (mothers, siblings) as intermediate sources Model predictions differed in terms of the relative importance of cattle vs. small ruminants as additional sources.
Conclusions
The transmission pathways of C. jejuni in our study area are highly complex and interdependent. While chickens are the most important reservoir of C. jejuni, ruminant reservoirs also contribute to the infections. The currently nonculturable species Candidatus C. infans is also highly prevalent in infants and is likely anthroponotic. Efforts to reduce the colonization of infants with Campylobacter and ultimately stunting in low-resource settings are best aimed at protecting proximate sources such as caretakers’ hands, food and indoor soil through tight integration of the currently siloed domains of nutrition, food safety and water, sanitation and hygiene.
ABU Easy Go! Development and Optimization of a Machine Learning-Powered Chatbot for FAQ Assistance at Ahmadu Bello University, Zaria.
Authors: SULAIMAN Mansur Adisa 
Published: January 2025

Abstract

The advent of artificial intelligence (AI) and machine learning (ML) has significantly transformed how organizations interact with their stakeholders, with chatbots emerging as pivotal tools for enhancing user engagement and streamlining communication processes. This research introduces ABU Easy-Go!, a machine learning-powered chatbot developed to manage frequently asked questions (FAQs) at Ahmadu Bello University (ABU), Zaria, Nigeria. The chatbot leverages natural language processing (NLP) to provide instant, accurate responses to a broad spectrum of queries related to admission procedures, course registrations, campus facilities, and event schedules. The research outlines the design, implementation, and optimization of the chatbot, detailing the use of machine learning models, recurrent neural networks (RNNs) and transformer-based architectures BERT, to understand and generate responses in natural language. The technological framework incorporates Dialogflow platform and custom solution using TensorFlow and PyTorch to ensure a robust and scalable system. Integration with the Pantheon CMS and Tawk.to chat services was achieved to facilitate seamless user interaction. Testing and evaluation revealed high performance, with the chatbot achieving a training accuracy of 98% and a testing accuracy of 93%, reflecting strong effectiveness in handling queries. Post-optimization metrics demonstrated further improvements, with test accuracy increasing to 95%. This research demonstrates the potential of AI-powered chatbots in enhancing administrative efficiency in higher education institutions and provides insights into future directions for advancing chatbot capabilities through reinforcement learning and multimodal integration.
NEUROLOGIC MANIFESTATIONS ASSOCIATED WITH COVID-19 IN PEDIATRIC PATIENTS AT DR. KARIADI HOSPITAL SEMARANG
Authors: Sareharto Tun Paksi , Dania Emeralda Firdausy  , Santoso Jaeri  , Alifiani Hikmah Putranti  
Published: January 2025

Background: Coronavirus Disease-19 (COVID-19), a severe acute respiratory syndrome, stems from a novel coronavirus known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The common symptoms and signs of COVID-19 are fever, cough, diarrhea, and myalgia as well as neurological manifestations. Neurological manifestations of COVID-19 in adult patients have been well recognized, unfortunately, there is limited evidence of neurological manifestations of COVID-19 in children, especially in Indonesia, so herewith we describe neurological manifestations in children, to contribute to the knowledge in the fields of pediatric health and neurology, particularly their correlation with COVID-19.
Objective: To determine the neurological manifestations in children with COVID-19.
Method: An observational analytic study among 124 pediatric patients with COVID-19 at Dr. Kariadi Hospital Semarang. Demographic and clinical data were obtained from medical records. To determine risk factors for the occurrence of neurological manifestation, the chi-square test, Fisher exact test, and Mann-Whitney U-test were performed.
Results: Out of 124 subjects, 49 (39.5%) developed neurological manifestations, including headache (10%), seizure (23%), weakness (5%), dizziness (0.8%), vision impairment (0.8%), ataxia (0.8%), coma (11.3%), paresthesia (0.8%), acute encephalopathy (3.2%), sympathetic storming (0.8%), and others (9.7%). Diagnosis of Multisystem Inflammatory Syndrome in Children (MIS-C) was found in 10 (8.1%) patients, in addition, there was a significant association between the diagnosis of MIS-C, comorbid conditions, and outcomes among patients and neurological manifestations.
Conclusion: The most common neurological manifestation experienced by pediatric patients with COVID-19 in this study was seizures. Patients with MIS-C and pre-existing conditions are at higher risk of experiencing neurological manifestations. Children with neurological manifestations more frequently presented with worse outcomes.
FUNGSI GANDA AGROFORESTRI KOPI: KONSERVASI CADANGAN KARBON DAN KEANEKARAGAMAN VEGETASI
Authors: Sari Rika Ratna , Ishaq Rizki Maulana , Purnamasari Eka , Saputra Danny Dwi 
Published: January 2025

Coffee agroforestry systems have great potential in optimizing the dual function of carbon and biodiversity conservation, especially in areas with high land use pressure. However, although coffee agroforestry has been widely practiced in Indonesia, the specific relationship pattern between carbon stocks and vegetation biodiversity is still not well understood. This study aimed to evaluate (1) the role of coffee agroforestry in maintaining vegetation diversity and carbon sequestration compared to disturbed forests (HT) and (2) the relationship between carbon stocks and biodiversity at various plant growth stages. Three land use systems were selected such as HT and complex (AFM) and simple (AFS) coffee-based agroforestry systems. The number of trees, species richness (R), Shannon-wiener index (H’), species evenness (E), and carbon stocks were measured in 12 plots (100 m x 20 m) for each vegetation growth stages (seedlings, saplings, poles, and trees). The results showed that the H index in coffee agroforestry was generally low to moderate (0.57-2.05), with the highest diversity in the tree category. The diversity level of AFM could mimic HT. In terms of carbon stock, HT had the highest stock (82±19 Mg ha-1), while total carbon stock showed a positive relationship with H index in all vegetation stages (R2=0,13-0,57). In contrast, the relationship between soil carbon stock and H index tended to be weak (R2=0,10). This study emphasizes the importance of maintaining total carbon stock through diverse vegetation in agroforestri systems to support climate change mitigation and biodiversity conservation.
KOMPOSISI NUKLEOTIDA GEN MITOKONDRIA D-LOOP IKAN GLODOK (Periophthalmus argentilineatus Valenciennes, 1837) DARI PANTAI BAROS BANTUL, D.I. YOGYAKARTA
Authors: Arisuryanti Tuty 
Published: January 2025

Indonesia merupakan negara yang memiliki luas wilayah perairan lebih luas daripada wilayah daratannya. Oleh karena itu, keragaman organisme yang mendiami perairan Indonesia sangat beranekaragam. Mangrove merupakan salah satu ekosistem perairan yang ada di Indonesia. Salah satu jenis ikan yang dapat dijumpai pada ekosistem mangrove adalah ikan glodok spesies Periophthalmus argentilineatus. Salah satu hutan mangrove yang menjadi habitat P. argentilineatus adalah Hutan Mangrove di Pantai Baros, Bantul, Daerah Istimewa Yogyakarta. Ekosistem mangrove dipengaruhi oleh pasang surut air laut, sehingga ikan glodok memiliki adaptasi unik yakni bernapas dengan insang saat air pasang dan bernapas dengan kulit tubuh dan lapisan lendir di mulut dan kerongkongannya saat air surut atau kering serta menyimpan air di rongga insangnya. Namun, penelitian mengenai komposisi nukleotida sekuen gen D-loop mitokondria masih sangat terbatas. Padahal penelitian karakterisasi genetik ikan glodok penting dilakukan untuk memperoleh informasi data yang dapat digunakan dalam upaya konservasi. Oleh karena itu, penelitian ini bertujuan untuk mengetahui komposisi nukleotida sekuen gen mitokondria D-loop ikan glodok spesies P. argentilineatus yang disampling dari Pantai Baros, Bantul, Daerah Istimewa, Yogyakarta. Ekstrasi DNA dilakukan pada ketujuh sampel ikan glodok, diikuti dengan amplifikasi DNA menggunakan primer universal L15995 dan H16498 yang menargetkan gen D-loop mitokondria. Hasil penelitian menunjukkan adanya variasi komposisi nukleotida T, A, C, dan G dari ketujuh sampel ikan glodok yang diteliti. Rata-rata komposis nukleotida T, A, C, dan G berturut-turut adalah 25,77%, 27,35%, 21,46%, dan 25,42 dengan rata-rata komposisi nukleotida A+T yaitu 47,2% sedangkan G+C yaitu 52,77%
Legal Protection of Brands on Regional Food Products for the Bernung Community in Lampung Province
Authors: Famulia Ledy , Sari Ratna Kumala , Dakum Dakum , Rusjana Muhammad 
Published: January 2025

Bernung is one of the villages in Gedong Tataan District, Pesawaran Regency, Lampung Province. The majority of the people of Bernung Village are entrepreneurs in the culinary sector, especially culinary delights made from bananas and cassava. Bananas and cassava are basic ingredients that are also commonly grown by the Bernung Community. Local village officials have conducted a lot of training for the Bernung Village Community in order to improve the quality of the culinary products produced. Apart from improving product quality, what is also no less important is increasing public awareness regarding the protection of intellectual property rights from the efforts they undertake to protect people's intellectual property rights. The method used is to provide legal education regarding the importance of legal protection regarding intellectual property rights to the people of Bernung Village, Pesawaran Regency, Lampung. This legal counseling was carried out by the Community Service Team from the Faculty of Law, Sang Bumi Ruwa Jurai University. The impact of this legal education can be felt directly by the Bernung Village Community, and several others have even implemented it directly by registering their trademarks with the Directorate General of Intellectual Property, Ministry of Law and Human Rights.

Abstrak
Perlindungan Hukum Merk terhadap Produk Makanan Khas Daerah bagi Masyarakat Bernung di Lampung. Bernung merupakan salah satu desa yang berada di Kecamatan Gedong Tataan, Kabupaten Pesawaran, Provinsi Lampung. Masyarakat Desa Bernung mayoritas menjadi pelaku usaha pada bidang kuliner, terutama kuliner berbahan dasar pisang dan singkong. Pisang dan singkong merupakan bahan dasar yang juga umum ditanam oleh Masyarakat Bernung. Aparat desa setempat telah banyak melakukan pelatihan-pelatihan kepada Masyarakat Desa Bernung dalam rangka meningkatkan kualitas produk kuliner yang dihasilkan. Selain meningkatkan kualitas produk, yang juga tidak kalah penting adalah meningkatkan kesadaran bagi masyarakat mengenai perlindungan hak kekayaan intelektual dari usaha yang mereka lakukan dalam rangka melindungi hak kekayaan intelektual masyarakat. Metode yang digunakan adalah dengan melakukan penyuluhan hukum mengenai pentingnya perlindungan hukum tentang hak kekayaan intelektual kepada Masyarakat Desa Bernung, Kabupaten Pesawaran, Lampung. Penyuluhan hukum ini dilakukan oleh Tim Pengabdian dari Fakultas Hukum Universitas Sang Bumi Ruwa Jurai. Dampak dari adanya penyuluhan hukum ini dapat langsung dirasakan oleh Masyarakat Desa Bernung, bahkan beberapa lainnya juga langsung mengimplementasikannya dengan mendaftarkan merk dagang mereka ke Direktorat Jenderal Kekayaan Intelektual Kementrian Hukum dan HAM.
Defending Democracy Through Democracy Defenders Accelerator Bootcamp in Estonia
Authors: Al-Fatih Sholahuddin , Hirmo Meelika 
Published: January 2025

Democracy is becoming mainstream in modern countries. Even though many people choose it, implementing democracy does not always run smoothly. Some countries show inappropriate democratic practices. Through this international community service, the service tries to share stories with the world about the practice of democracy in Indonesia, especially for the younger generation. This community service agenda will occur in Estonia from March 27 to April 5, 2023. The service method is a mixed model, with socialization sessions, discussions, and class material. It is hoped that the results of this service will provide benefits to democracy activists throughout the world. Maintaining democracy requires methods and strategies, such as strengthening godship values ​​in legal products, both at the central and regional levels, accommodating developing values ​​and culture in society as living law, and protecting oneself from values ​​not by the identity of the nation and state.

Abstrak
Membela Demokrasi Melalui Pelatihan Akselerator Pembela Demokrasi di Estonia
Demokrasi menjadi arus utama bagi negara-negara modern. Meskipun banyak dipilih, implementasi demokrasi tidak selamanya berjalan lancar. Beberapa negara, menunjukkan praktik demokrasi yang tidak semestinya. Melalui pengabdian kepada masyarakat bertaraf Internasional ini, pengabdi mencoba berbagi cerita kepada dunia, praktik demokrasi di Indonesia, khususnya bagi generasi muda. Agenda pengabdian kepada masyarakat ini berlangsung di Estonia, pada tanggal 27 Maret hingga 5 April 2023. Metode pengabdian yang digunakan adalah model campuran, dimana ada sesi sosialisasi, diskusi juga materi di kelas. Hasil dari pengabdian ini diharapkan dapat memberikan manfaat bagi pegiat demokrasi di seluruh dunia, bahwa untuk mempertahankan demokrasi dibutuhkan cara dan strategi, seperti: memperkuat nilai-nilai ketuhanan dalam produk hukum, baik di tingkat pusat maupun daerah, mengakomodasi nilai-nilai dan budaya yang berkembang di tengah masyarakat sebagai living law dan memproteksi diri dari nilai yang tidak sesuai dengan jati diri bangsa dan negara.