bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of tamsulosin hydrochloride with terazosin combination therapy for chronic prostatitis Type-III b
Authors: Duan Bin , Wang Xinxi 
Published: January 2022

Objectives: To study the therapeutic effects of combined tamsulosin hydrochloride and terazosin treatment for patients with chronic prostatitis Type-III b.
Methods: This study involved 180 patients with chronic prostatitis Type-III b treated between January 2018 and December 2020 conducted at Nanhua Hospital Affiliated to Nanhua University. Patients were randomly divided into two equal groups: one receiving oral terazosin hydrochloride tablets only (control group), and one orally receiving both tamsulosin hydrochloride sustained-release tablets and terazosin hydrochloride tablets (observation group). Outcome measurements included symptom scoring, inflammatory cytokine levels, as well as white blood cell and lecithin body counts in the prostatic fluid.
Results: After 30 days of treatment, the observation group showed greater treatment effectiveness (86.67% vs. 73.33%, P<0.05). QLS, USS, PS, and NIH-CPSI symptom scores were lower in the observation group than the control group (P<0.05). No differences in adverse event distribution and incidence were noted. EPS IL-2 increased more in the observation group, while PGE-2, MIP-1α, and MIP-2 decreased more in the observation group. WBC levels decreased more in the observation group, while lecithin body levels increased more in the observation group.
Conclusion: The combination of tamsulosin hydrochloride and terazosin for the treatment of patients with chronic prostatitis Type-III b has a significant effect. This approach reduced patient symptoms, lowered inflammatory biomarkers, and generally improved quality of life. This approach appears to have clinical value worthy of future investigation.
doi: https://doi.org/10.12669/pjms.38.3.4931
How to cite this:Duan B, Wang X. The effectiveness of tamsulosin hydrochloride with terazosin combination therapy for chronic prostatitis Type-III b. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.4931
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Multidisciplinary cooperative first aid model for the treatment of patients with pelvic and multiple fractures
Authors: Han Yun , Peng Ganggang , Liu Lijun , Xie Xiaohua 
Published: January 2022

Objectives: To retrospectively evaluate a multidisciplinary cooperative first aid model for the treatment of patients with pelvic and multiple fractures in the emergency department.
Methods: The records of patients with pelvic fractures complicated with multiple fractures treated in our hospital from February 2020 to April 2021 were selected, of which 34 patients received conventional trauma first aid mode (control group) and 34 patients received multidisciplinary joint first aid mode (study group). We compared pelvic function (Majeed functional score) and fracture reduction outcomes, as well as serum inflammatory factor levels and complication rates after treatment between the two groups.
Results: The Majeed score in the study group (90.15 ± 6.83) was higher than that in the control group (75. 47 ± 5.35), and the differences were statistically significant (P<0.05). The value for combined excellent and good rates of fracture reduction in the study group (85.29%, 29/34) was significantly higher than that in the control group (58.82%, 20/34), and the difference was statistically significant(P<0.05). We found similar levels of TNF-a and IL-6 between the two groups at admission (P>0.05); however, the serum levels of TNF-a and IL-6 in the study group were lower than those in the control group on the fifth day after admission, and the difference was statistically significant (P<0.05 or P<0.01). The incidence of complications in the study group (17.64%, 6/34) was significantly lower than that in the control group (61.76%, 21/34), the difference was statistically significant (P<0.05).
Conclusion: The multidisciplinary cooperative first aid model for the treatment of patients with pelvic and multiple fractures can effectively shorten the treatment time, increase the excellent functional rehabilitation rate, inhibit the release of inflammatory factors, and reduce the incidence of complications (such as infections), when compared to the conventional trauma emergency system.
doi: https://doi.org/10.12669/pjms.38.3.5014
How to cite this:Han Y, Peng G, Liu L, Xie X. Multidisciplinary cooperative first aid model for the treatment of patients with pelvic and multiple fractures. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.5014
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Triglyceride to High-Density Lipoprotein Ratio can predict coronary artery calcification
Authors: Wang Beilei , Hua Jinsheng , Ma Likun 
Published: January 2022

Objectives: We assessed the TG/HDL-C ratio as a predictor for the presence of coronary artery calcifications (CACs).
Methods: We collected demographic characteristics (age and gender), physical examination (height, weight, BMI, SBP, DBP), comorbidities, medication use, and laboratory variables Triglyceride to High-Density Lipoprotein (TG, HDL-C, TG/HDL-C, UA, TBG, 25-OH-VitD3); and we used coronary angiography to determine the presence of CACs. We performed univariate and multivariate analyses to evaluate the correlation between the TG/HDL-C ratio and CACs and established a predictive model.
Results: CAC was present in 121 patients (25.80%). The levels of TG and TG/HDL-C ratio in the CAC group were higher than those in the non-CAC group, while the level of HDL-C in the CAC group was lower than that in the non-CAC group. The univariate analysis showed that the TG/HDL-C ratio was associated with CAC (OR, 0.021; 95% CI, 0.008 to 0.052; P<0.001), and the multivariate analysis indicated that the ratio was an independent risk factor for CAC (OR, 4.088; 95% CI, 2.787-5.996; P<0.001). Using the ratio to establish a prediction model, the area under the ROC curve was 0.814 (95% CI, 0.775-0.853; P<0.001), suggesting that the TG/HDL-C ratio has a high diagnostic efficiency. The diagnostic threshold was 1.037, and the corresponding sensitivity and specificity were 89.3% and 60.5%, respectively.
Conclusion: The Triglyceride to High-Density Lipoprotein TG/HDL-C ratio is an independent risk factor for CAC with good diagnostic efficacy.
Abbreviations: TG: Triglycerides, HDL-C: High-Density Lipoprotein, CAC: Coronary Artery Calcifications, BMI: Body Mass Index, SBP: Systolic Blood Pressure, DBP: Diastolic Blood Pressure, UA: Uric Acid, FBG: Fasting Blood Glucose, 25-OH-VitD3: 25-Hydroxyvitamin D3, ACEI: Angiotensin-Converting Enzyme Inhibitors, ARB: Angiotensin Receptor Blockers, CCB: Calcium Channel Blockers, ARNI: Angiotensin Receptor-Neprilysin Inhibitor, CAG: Coronary Angiography, AUCROC: Area Under the Receiver Operating Curve.
doi: https://doi.org/10.12669/pjms.38.3.5290
How to cite this:Wang B, Hua J, Ma L. Triglyceride to High-Density Lipoprotein Ratio can predict coronary artery calcification. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.5290
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Correlation between α-SMA and ß-catenin levels in bronchoalveolar lavage fluid and severity of pneumonia
Authors: Li Xiaoying , Jiang Zinan 
Published: January 2022

Objectives: To assess the association of bronchoalveolar lavage fluid (BALF) α-SMA and ß-catenin levels and the severity of pneumonia.
Methods: The records of patients with severe pneumonia treated in our hospital from June 2019 to June 2020 were selected. The clinical outcome was observed within 10 days. For the purpose of analysis, patients were divided into two groups according to the outcome, 47 cases in the improvement group and 39 cases in the deterioration group. The intubation time, mechanical ventilation time and APACHE II score 10 days after admission were compared between the two groups; We assessed pulmonary infections using the clinical pulmonary infection score(CPIS). The levels of α-SMA and ß-catenin in bronchoalveolar lavage fluid at different time points were compared and analyzed, to analyze the association between the levels and the CPIS.
Results: The APACHE II score in the improvement group were lower than those in the deterioration group (P<0.05). The expressions of α-SMA and ß-catenin in the BALF of patients in the improvement group were significantly lower than those of patients in the deterioration group on day 1, 3, and 7 (P<0.05); and the expressions of α-SMA and ß-catenin in the BALF of patients in the improvement group decreased with time, while those of patients in the deterioration group increased gradually with time(P<0.05). The expressions of α-SMA and ß-catenin in patients with CPIS>6 was significantly higher than those in patients with CPI≤6(P<0.05). Pearson correlation analysis showed that the levels of α-SMA and ß-catenin in BALF were positively correlated with the CPIS.
Conclusion: The levels of α-SMA and ß-catenin in BALF are closely associated with the clinical condition of patients with severe pneumonia; the levels are positively associated with the severity of the disease and they increase with symptomatic worsening.
doi: https://doi.org/10.12669/pjms.38.3.5329
How to cite this:Li X, Jiang Z. Correlation between α-SMA and ß-catenin levels in bronchoalveolar lavage fluid and severity of pneumonia. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.5329
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A retrospective analysis of emergency hysterectomy intervention strategy in obstetrics
Authors: Fang Zhuanji , Zhang Huale , Zheng Shuisen , Weng Lingling , Yan Jianying 
Published: January 2022

Objectives: To investigate the indications of obstetric emergency hysterectomy and analyze the clinical effects of subtotal hysterectomy and total hysterectomy.
Methods: We included 247 hospitalized women who had undergone abdominal hysterectomy due to obstetric reasons in Fujian Province Maternity and Child Health Hospital (a provincial class-A hospital) and Ningde People’s Hospital (a primary Class-B hospital) between January 2002 and December 2018. We identified surgical indications and clinical characteristics of the patients. Furthermore, the patients from Fujian Provincial Maternity and Child Health Hospital were subdivided into subtotal hysterectomy group and total hysterectomy group to examine general operation conditions, and postoperative complications.
Results: The main surgical indications for emergency obstetric hysterectomy in Fujian Maternity and Child Health Hospital were placental implantation (49.6%) and uterine weakness (31.9%), while uterine weakness (37.5%) was the most important indication in Ningde People’s Hospital. No differences were found in operation time, hospitalization time, intraoperative blood loss, postpartum blood loss, and intraoperative fresh frozen plasma transfusion between the subtotal hysterectomy group and the total hysterectomy group. Postoperative test parameters, including postoperative prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), hemoglobin (HGB), and hematocrit (HCT), were not significantly different between the two groups. No significant difference was noted in postoperative vesicoureteral injury, pelvic hematoma, infection, and disseminated intravascular coagulation (DIC) incidence, but renal failure incidence was different (P=0.040).
Conclusion: The treatment effect of subtotal hysterectomies for the cases without placenta accreta and placenta previa was similar in the two hospitals. There is no statistically significant difference in therapeutic effect between total hysterectomy and subtotal hysterectomy.
doi: https://doi.org/10.12669/pjms.38.3.5335
How to cite this:Fang Z, Zhang H, Zheng S, Weng L, Yan J. A retrospective analysis of emergency hysterectomy intervention strategy in obstetrics. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.5335
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Efficacy and safety of fenfluramine in the treatment of Dravet syndrome - literature review
Authors: Stefaniak Martyna , Pietrzak Zofia , Dzikowski Piotr , Nowicka Emilia , Obel Michał , Piecewicz-Szczęsna Halina 
Published: January 2022

Dravet Syndrome is a severe, drug-resistant, and rare epileptiform disorder that is typically presented in the first year of life in an otherwise healthy child. It is characterized by prolonged seizures that are often resistant to current anti-epileptic drug regimens, which made them poorly controlled, and almost 50% of patients experience at least four tonic-clonic seizures per month. There are three new medicines: stiripentol, cannabidiol, and fenfluramine, with documented efficacy and safety as adjunctive therapies in pharmacoresistant Dravet syndrome treatment.
This study aimed to assess the efficacy and safety of fenfluramine in the treatment of Dravet syndrome. Our study material consisted of publications, which were found in PubMed, Google Scholar, and Embase databases. In order to find the proper publications, the search has been conducted with the use of a combination of keywords like: “fenfluramine”, “Dravet syndrome”, “epilepsy treatment”, “Dravet syndrome pediatric patients”. The first step was to find proper publications from the last 10 years. The second step was to carry out an overview of the found publications.
Results of mentioned studies proved that in Dravet syndrome, fenfluramine provided a significantly greater reduction in convulsive seizure frequency compared with placebo. No patient developed valvular heart disease or pulmonary arterial hypertension, the side effects that occurred during its use were mild and the drug was generally well-tolerated. The bioequivalence and tolerability of single oral doses of fenfluramine hydrochloride oral solution in the fed and fasted states support drug administration without regard to meals. Fenfluramine may represent a new important treatment option for Dravet syndrome.
Solar-Powered Electrocoagulation System for Tofu Wastewater Treatment and its Characteristic
Authors: Muryanto Muryanto , Sari Ajeng Arum , Pertiwi Sunu , Prasetyo Danar Aji , Sudarno Sudarno 
Published: January 2022

This study aims to investigate the ability of solar-powered electrocoagulation for tofu wastewater, especially for reducing COD and TSS. This feasibility was compared with conventional electrocoagulation using electricity from the state electricity company. The study was conducted on a laboratory scale using a batch reactor electrocoagulation and aluminium electrode. The types of electrolytes used are sodium chloride and potassium chloride. The contact time is 0, 2, 4, 6, and 8 hours. The results showed that removal of COD and TSS in tofu wastewater increases with a longer electrolysis time. During two hours of electrolysis time, the removal of COD and TSS were 25 and 53.85%, respectively. This process yielded the highest COD and TSS removal of 75 and 76.9%, respectively, at 6 hours. Pseudo-second order kinetics about COD removal, both in conventional and solar panel systems, is concluded. By adding NaCl electrolytes, the conductivity of wastewater was increased, and then the removal of COD and TSS was also increased. At the end of the electrolysis time (5 hours), the pH of wastewater was neutral. The results of sludge characterization using FTIR showed the presence of hydroxyl groups, amide compound, and aromatic compound. The process of using solar panels gives results slightly different from conventional electricity, but has advantages in terms of lower operating costs and environmental friendly.
Ricci almost solitons with associated projective vector field
Authors: Sharma Ramesh , Deshmukh Sharief 
Published: January 2022

Abstract
A Ricci almost soliton whose associated vector field is projective is shown to have vanishing Cotton tensor, divergence-free Bach tensor and Ricci tensor as conformal Killing. For the compact case, a sharp inequality is obtained in terms of scalar curvature.We show that every complete gradient Ricci soliton is isometric to the Riemannian product of a Euclidean space and an Einstein space. A complete K-contact Ricci almost soliton whose associated vector field is projective is compact Einstein and Sasakian.
Bifurcation analysis for a modified quasilinear equation with negative exponent
Authors: Chen Siyu , Santos Carlos Alberto , Yang Minbo , Zhou Jiazheng 
Published: January 2022

AbstractIn this paper, we consider the following modified quasilinear problem:−Δu−κuΔu2=λa(x)u−α+b(x)uβinΩ,u>0inΩ,u=0on∂Ω,$$\begin{array}{} \left\{\begin{array}{c}\, -{\it\Delta} u-\kappa u{\it\Delta} u^2 = \lambda a(x)u^{-\alpha}+b(x)u^\beta \, \, in\, {\it\Omega}, \\\!\! u \gt 0 \, \, in\, {\it\Omega}, \, \, \, \, \, \, \, u = 0 \, \, on \, \partial{\it\Omega} , \\ \end{array}\right. \end{array} $$whereΩ⊂ ℝNis a smooth bounded domain,N≥ 3,a,bare two bounded continuous functions,α> 0, 1 <β≤ 22*− 1 andλ> 0 is a bifurcation parameter. We use the framework of analytic bifurcation theory to obtain an analytic global unbounded path of solutions to the problem. Moreover, we get the direction of solution curve at the asmptotic point.
Absolute Stability of Neutral Systems with Lurie Type Nonlinearity
Authors: Diblík Josef , Khusainov Denys Ya , Shatyrko Andriy , Baštinec Jaromír , Svoboda Zdeněk 
Published: January 2022

AbstractThe paper studies absolute stability of neutral differential nonlinear systemsx˙(t)=Axt+Bxt−τ+Dx˙t−τ+bf(σ(t)),σ(t)=cTx(t),t⩾0$$ \begin{align}\dot x(t)=Ax\left ( t \right )+Bx\left ( {t-\tau} \right ) +D\dot x\left ( {t-\tau} \right ) +bf({\sigma (t)}),\,\, \sigma (t)=c^Tx(t), \,\, t\geqslant 0 \end{align} $$wherexis an unknown vector,A,BandDare constant matrices,bandcare column constant vectors, 𝜏 > 0 is a constant delay andfis a Lurie-type nonlinear function satisfying Lipschitz condition. Absolute stability is analyzed by a general Lyapunov-Krasovskii functional with the results compared with those previously known.
A revised model for the effect of nanoparticle mass flux on the thermal instability of a nanofluid layer
Authors: Alharbi Ozwah S. , Abdullah Abdullah A. 
Published: January 2022

Abstract
A revised model of the nanoparticle mass flux is introduced and used to study the thermal instability of the Rayleigh-Benard problem for a horizontal layer of nanofluid heated from below. The motion of nanoparticles is characterized by the effects of thermophoresis and Brownian diffusion. The nanofluid layer is confined between two rigid boundaries. Both boundaries are assumed to be impenetrable to nanoparticles with their distribution being determined from a conservation condition. The material properties of the nanofluid are allowed to depend on the local volume fraction of nanoparticles and are modelled by non-constant constitutive expressions developed by Kanafer and Vafai based on experimental data. The results show that the profile of the nanoparticle volume fraction is of exponential type in the steady-state solution. The resulting equations of the problem constitute an eigenvalue problem which is solved using the Chebyshev tau method. The critical values of the thermal Rayleigh number are calculated for several values of the parameters of the problem. Moreover, the critical eigenvalues obtained were real-valued, which indicates that the mode of instability is via a stationary mode.
Solution growth of chalcopyrite Cu(In1−x
Ga
x
)Se2 single crystals for high open-circuit voltage photovoltaic device
Authors: Nagaoka Akira , Shigeeda Yusuke , Nishioka Kensuke , Masuda Taizo , Yoshino Kenji 
Published: January 2022

Abstract
I–III–VI2 Chalcopyrite Cu(In1−x
Ga
x
)Se2 (CIGS) has attracted attention as absorbing layer in photovoltaic (PV) device. In this study, we investigated the fundamental properties of CIGS single crystals, and fabricated single crystal-based PV device. CIGS single crystals without secondary phase were successfully grown by In-solvent traveling heater method (THM). The conversion of conduction type from n- to p-type can be observed above 0.3 of Ga ratio x because of high acceptor defect concentration. PV device based on high-quality CIGS bulk single crystal demonstrates high open-circuit voltage of 0.765 V with the efficiency of 12.6%.
Stress concentration effect on deflection and stress fields of a master leaf spring through domain decomposition and geometry updation technique
Authors: Ghuku Sushanta , Saha Kashi Nath 
Published: January 2022

Abstract
Theoretical and experimental large deflection and stress analysis of a master leaf spring considering stress concentration effect of clamping is reported. The non-uniformly curved master leaf spring under three point bending subjected to moving boundaries is modeled. Geometrically nonlinear strain-displacement relations, as necessary for the theoretical analysis, are derived through visualization of physics behind the large deformation problem. An embedded curvilinear coordinate system is considered, to study the combined effects of non-uniform curvature, bending, stretching and shear deformation including cross-sectional warping. Governing equation of the non-uniformly curved beam system is derived in variational form using energy method, based on linear material constitutive relations and the derived nonlinear kinematic relations. An iterative solution scheme through successive geometry updation is developed and executed in MATLAB® software to solve the governing equation involving strong geometric nonlinearity together with complicating moving boundary effect. Experimental deflection profiles under static loading are obtained through manual image processing technique using AutoCAD® software. Whereas, strain measurements are performed using strain gauges with data acquisition system (HBM-MX840B). Comparison between the theoretical and experimental results lead towards observation on stress concentration effect due to presence of geometric discontinuity in form of a small hole in the physical system. A modified formulation is proposed using domain decomposition method incorporating effect of geometric discontinuity through an equivalent curved beam geometry of variable cross-section. The modified theoretical model is validated successfully with the experimental results, and observations on stress characteristics and effect of hole diameter to beam width ratio are made.