bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtual Infrastructure based Routing Algorithm for IoT enabled Wireless Sensor Networks with Mobile Gateway
Authors: Jang Bahadur Dilip Kumar , Lakshmanan L. 
Published: September 2022

The IoT technology is seeking the attention of industry and researcher day by day due to its large number of applications and is off monitoring and controlling the object from the remote location. The very basic and important element of IoT is wireless sensor network where sensor nodes are attached with the object and generates the sensory data related to the object an actuator can provide the movement to the object. To make it a success reliable and efficient communication model is the main requirement. To fulfil the objective related to IoT application success in this paper a communication protocol called virtual infrastructure based routing algorithm is proposed. In this proposal a virtual cross region structure is formed in the central of the sensor network, which is called meeting region. In this meeting region the sensor nodes send their generated data and the gateway node receives those data. The problem of energy hole, the mobile gateway node is considered in this proposal. The proposed algorithm is implemented using the standard wireless sensor network simulator tool and compared the performance of the proposed algorithm with the existing algorithm based on some standard performance metrics. The simulation outcome exhibits that the proposed algorithm outperformed the existing algorithms in different performance metrics.
World seismicity maps compiled from ESSA, Coast and Geodetic Survey, epicenter data, 1961-1967
Authors: Barazangi Muawia , Dorman James 
Published: September 2022

Abstract
Seismicity Maps are published from the preliminary determinations of hypocenters of the USCGS, Environmental Science Services Administration, Department of Commerce. The seismicity covers the interval January 1, 1961 through December 31, 1967. Two large plates accompany the paper. Plate 1 contains a plot of all epicenters; Plate 2 shows a plot of all events deeper than 100 km.
Some improvements for existing simple Approximations of the Normal Distribution Function
Authors: Hanandeh Ahmad , Eidous Omar M. 
Published: September 2022

Due to the widespread applicability and use of the normal distribution, a need has arisen to approximate its cumulative distribution function (cdf). In this article, five new simple approximations to the standard normal cdf are developed. In order to assess the accuracy of the proposed approximations, both maximum absolute error and mean absolute error were used. The maximum absolute errors of the proposed approximations lie between 0.00095 and 0.00946, which is highly accurate if compared to the existing simple approximations and quite sufficient for many real-life applications. Even though simple approximations may not as accurate as complicated ones, they are, though, fairly good when judged vis-a-vis their simplicity.
Prevalence and Associated Risk Factors of Intestinal Parasitic Infections among Patients Visiting a Referral Hospital in Tehran Province, Iran
Authors: Zarei Ahmad , Mohebali Mehdi , Agholi Mahmoud , Jonaidi Jafari Nematollah , Mohammadzadeh Tahereh 
Published: September 2022

Background: Intestinal parasitic infections (IPIs) are still considered a public health problem of mankind, particularly in immunocompromised patients. We aimed to determine the prevalence of IPIs with an emphasis on immunocompromised patients in a referral hospital in Tehran Province, Iran.
Methods: In this cross-sectional study, 442 fecal specimens were collected randomly from patients, referred to Baqiyatallah Hospital in Tehran Province, Iran from May to September 2020. The collected specimens were examined using wet-mount, trichrome and modified Ziehl-Neelsen staining, formalin-ether concentration, and agar plate culture.
Results: The prevalence of IPIs was found 17.0% (95% CI: 13.6-20.8%). The prevalence of protozoan parasites (16.3%; 95% CI: 13.0-20.1%) was significantly higher than helminthic parasites (0.7%; 95% CI: 0.1-2.0%). Blastocystis spp., Giardia lamblia, and Entamoeba coli were the most common intestinal protozoan with a prevalence of 12.2%, 1.6%, and 1.4%, respectively. E. histolytica/E. dispar/E. moshkovskii, Iodamoeba bütschlii, Cryptosporidium spp., Chilomastix mesnili as protozoan species and Hymenolepis nana, Dicrocoelium dendriticum, and Ascaris lumbricoides as helminthic species were the other detected parasites. Multiple logistic regression revealed a significant association of IPIs infections with stool consistency and the status of immune system.
Conclusion: The prevalence of IPIs among the patients who are immunocompromised was significantly higher than immunocompetent patients (P< 0.05). Periodic stool examinations for screening of IPIs should be included as a part of routine medical check-up in these patients.
A Schistosoma Colitis Case Misdiagnosed as Ulcerative Colitis in a Non-Endemic Area: A Case Report
Authors: Ak Çağatay , Sayar Suleyman , Kılıç Ebru Tarıkçı 
Published: September 2022

The differential diagnosis of bloody diarrhea is necessary to specify etiology and plan treatment. Misdiagnosis can lead to catastrophic results with the treatments to be given. In this case report, we present a case of schistosomal colitis mimicking ulcerative colitis in a 26-year-old Guinean male patient diagnosed in 2021.
Reconstruction of Triangular Fibrocartilage Complex Avulsions (Palmar 1C) with Associated Lunotriquetral and Dorsal Capsule Injury
Authors: Lenartowicz Karina A. , Miller Andrew J. , Mauermann Michelle L. , Shin Alexander Y. , Bishop Allen T. 
Published: September 2022

Case:
A 34-year-old farmer and railroad worker injured his left wrist when working at a railroad. The resulting dorsal-ulnar wrist blow caused disabling pain. Splits and 2 subsequent surgeries failed, including an arthroscopic triangular fibrocartilage complex (TFCC) debridement and thermal ablation. Subsequently, magnetic resonance imaging documented a rare Palmer type 1C distal TFCC avulsion. Function was restored and return to farming permitted by reconstruction of the ulnotriquetral (UT) ligament using an extensor carpi ulnaris (ECU) slip.

Conclusion:
Chronic Palmer type 1C TFCC injuries can be successfully treated with ECU reconstruction of the UT ligament.
Simultaneous Glomus Tumors of the Third and Fourth Toes
Authors: Kimura Tadashi , Kubota Makoto , Hattori Hidekazu , Saito Mitsuru 
Published: September 2022

Case:
A glomus tumor of the toes is rare, and as far as we know, there has been no report of simultaneous occurrence in 2 toes. A 45-year-old woman presented with forefoot pain. Based on imaging findings, glomus tumors of the third and fourth toes were suspected. Tumor resection was performed, and pathological examination confirmed the diagnosis of glomus tumors.

Conclusion:
In this case, it was difficult to recognize the tumors because they occurred simultaneously in 2 toes. Even for sites where a glomus tumor is rare, it is important to understand the characteristic symptoms through a detailed interview and examination.
Distal Adductor Magnus Avulsion Fracture Treated with Excision After Failure of Nonoperative Management
Authors: Batley Morgan G. , Ashe Katherine , Senese Matthew T. , Grady Matthew F. , Williams Brendan A. 
Published: September 2022

Case:
In this case report, we discuss a skeletally immature gymnast who presented with an isolated distal femoral adductor tubercle avulsion fracture that went on to develop a painful nonunion. After the failure of extensive nonoperative intervention, she had resolution of her symptoms with bony excision and soft-tissue repair.

Conclusion:
It is important for clinicians to be aware of this atypical injury pattern and that surgical intervention may be necessary because conservative treatment may not always resolve symptoms.
Lateral Interbody Fusion for Hyperlordosis and Negative Sagittal Vertical Axis Because of Accordion Phenomenon
Authors: Shima Koichiro , Sono Takashi , Murata Sohei , Takemoto Mitsuru , Takatsuka Kazutaka 
Published: September 2022

Case:
The accordion phenomenon is defined as the difference in the disc space observed on x-ray or computed tomography images taken in both standing and supine positions, which results in a discrepancy of local spinal alignment. Oblique lateral interbody fusion (OLIF) is a less invasive method of potentially correcting both coronal and sagittal spinal alignment. We present the case of a 66-year-old woman with rheumatoid arthritis treated with OLIF for degenerative disc disease presenting with hyperlordosis and negative sagittal vertical axis (SVA) because of the accordion phenomenon.

Conclusion:
OLIF for severe degenerative disc disease presenting with hyperlordosis and negative SVA because of the accordion phenomenon may be effective.
All-Internal Limb Lengthening with Simultaneous Corrective Osteotomy After Internal Hemipelvectomy
Authors: Femino Joseph D. , Nelson Scott C. , Agulnik Mark , Zuckerman Lee M. 
Published: September 2022

Case:
A 27-year-old woman with a Grade II chondrosarcoma in the right acetabulum underwent a Type II internal hemipelvectomy with an ischiofemoral fusion. She developed a 7.0-cm functional limb-length discrepancy with adduction of the hip at rest. Four years after surgery, she underwent a corrective osteotomy and limb lengthening with a magnetic lengthening nail. Eleven years after tumor resection and a successful pregnancy, she had symmetric leg lengths and ambulated without an assistive device.

Conclusions:
A magnetic lengthening nail is a viable option for correcting limb-length discrepancies after hemipelvectomy. If necessary, a simultaneous corrective proximal femoral osteotomy can be performed.
Lipoma Arborescens of the Upper Extremity With Anatomic Variation of the Palmaris Longus
Authors: Kostas-Agnantis Ioannis , Gkiatas Ioannis , Korompilia Maria , Kosmas Dimitrios , Motsis Efstathios , Pakos Emilios , Korompilias Anastasios 
Published: September 2022

Case:
We present a case of a patient who suffered from wrist swelling and had symptoms of carpal tunnel syndrome. The patient underwent ultrasound and magnetic resonance imaging, in which signs of joint effusion and a fatty synovial lesion were presented. The treatment included open excision of the tumor. In addition, the palmaris longus muscle had an anatomic variation with proximal and distal tendon portions. The histopathological examination disclosed lipoma arborescens of the synovial membranes of the joints.

Conclusion:
The recognition of this entity and its characteristics are important not only for correct diagnosis but also for the appropriate treatment.
Verification of Stress Transformation in Anisotropic Material Additively Manufactured by Fused Deposition Modeling (FDM)
Authors: Sehhat M. Hossein , Mahdianikhotbesara Ali , Yadegari Farzad 
Published: September 2022

Abstract
The widespread use of Additive Manufacturing (AM) has been extensively progressed in the past decade due to the convenience provided by AM in rapid and reliable part production. Fused Deposition Modeling (FDM) has witnessed even faster growth of application as its equipment is environmentally-friendly and easily adaptable. This increased use of FDM to manufacture prototypes and finished parts is accompanied by concerns that 3D printed parts do not perform the same as relatively homogeneous parts produced by molding or machining. As the interface between two faces of bonded material may be modeled by stress elements, in theory by modeling 3D printed layers subjected to tension at varying angles as transformed stress elements, the stress required to break the layer bonds can be determined. To evaluate such a relationship, in this study, the stresses calculated from stress transformation were compared with the behavior of 3D printed specimens subjected to tensile loads. The maximum principal stress was found to be constant relative to the layer angle, regardless of whether the specimen experienced failure at the layer interface or within the layer material, although the specimens with layers 75° relative to the load were notable exceptions to this finding. This failure at much lower stresses for the samples used in the 75° tests may be attributed to a possible environmental factor, such as temperature or humidity change, degrading the samples’ structural integrity.
Ethiopian Sheep Breeds’ Wool Fiber Yield and Moisture Regain Determination and Characterization
Authors: Liyew Erkihun Zelalem , Adamu Biruk Fentahun 
Published: September 2022

Abstract
Ethiopia has indigenous breeds of sheep such as Washera, Menz, Farta and Tikur. Small scale enterprises are using the wool fibers from these breeds to produce local products such as rugs, socks, sweaters, quilts, mattresses. This study investigates four Ethiopian sheep breeds wool fiber yield and moisture regain properties. 400 total sheep, 50 males and 50 female sheep were included in the study. The results revealed that the average wool fiber yield according to IWTO CWC standard of male sheep for Washera, Menz, Farta and Tikur were 89.29%, 88.29%, 73.33%, 81.74% and for female sheep were 88.75%, 81.91%, 73.23%, 80.80% respectively. The selected Ethiopian wool fiber yield showed higher as compared to some countries sheep breeds. The study also revealed that the raw wool fiber moisture regains values for male sheep of Washera, Menz, Farta and Tikur were 10.67%, 16.91%, 11.11%, 10.71% and for female sheep were 11.92% 15.91%, 11.83%, 9.22% respectively. This shows that the Ethiopian wool fiber having good fiber yield and moisture regain can be used as a source of manufacturing different wool products.
Transport Equipment Network Analysis: The Value-Added Contribution
Authors: GARCÍA LUIS GERARDO HERNÁNDEZ 
Published: September 2022

Abstract

Emerging in the 21st century, Network Science provides practical measures to interpret a system's interactions between the components and their links. Literature has focused on countries' interconnections on the final goods, but its application on the value-added from a network perspective in trade is still imitated. This paper applies network science properties and a multi-regional input-output analysis by using the UNCTAD-Eora Global Value Chain Database on the Transport Equipment value added on 2017 to unwrap the specific structural characteristics of the industry. Results show that the industry is highly centralized. The center of the network is dominated by developed countries, mainly from Europe, the United States, and Japan. Emerging countries such as China, Mexico, Thailand, and Poland also have an important position. In addition, the structure reveals two sub-hubs located in East Europe and North America. By extending to community detection, the network consists of three different communities led by Germany, the United States, and the United Kingdom, associated with more significant value-added flows. The study concludes that flows are not always consistent with the economy's geographical location as usually final goods analysis suggests, and highlight the need to continue using the complex network to reveal the world trade structure.
JEL Classification C38 C45 F1 F14
Menstrual blood derived endometrial stem cells alleviate neuroinflammation by modulating microglia polarization in cells and rats Parkinson’s disease models
Authors: Li Han , Wei Jinghui , Zhang Zhigang , Li Junyao , Ma Yaokai , Zhang Ping , Lin Juntang 
Published: September 2022

Abstract
Background: The hyperactivation of microglia is closely related to the development of Parkinson's disease (PD). Because of the extensive sources, non-invasive and periodical collection method, human menstrual blood-derived endometrium stem cells (MenSCs) have been explored as a promising tool for treatment of PD. This study aimed to investigate if MenSCs could inhibit neuroinflammation in PD rats by regulating M1/M2 polarization and to excavate the underlying mechanisms.
Methods: MenSCs was co-cultured with 6-OHDA-exposed microglia cell lines. Then the morphology of microglia cells and the level of inflammatory factors were assessed by immunofluorescence and qRT-PCR. After MenSCs was transplanted into the brain of PD rats, animal motor function, the expression of tyrosine hydroxylase (TH), and the level of inflammatory factors in the cerebrospinal fluid (CSF) and serum were detected to evaluate the therapeutic potential of MenSCs. Meanwhile, the expression of M1/M2 phenotype related genes was detected by qRTPCR. One protein array kit containing 1000 kinds of factors was used to detect the protein components in the conditioned medium of MenSCs. Finally, bioinformatic analysis was performed to analyze the function of factors secreted by MenSCs and the signal pathways involved in.
Results: MenSCs could suppress 6-OHDA-induced microglia cell activation and significantly decrease inflammation in vitro. After transplantation into the brain of PD rats, MenSCs improved animal motor function, which was indicated by the increased movement distance, ambulatory episodes, exercise time on the rotarod, and less contralateral rotation. Additionally, MenSCs reduced the loss of dopaminergic neurons and down-regulated the level of pro-inflammatory factors in the CSF and serum. Moreover, MenSCs significantly down-regulated the expression of M1 microglia markers and meanwhile up-regulated the expression of M2 microglia markers. 176 biological processes including inflammatory response, negative regulation of apoptotic process, and microglial cell activation were enriched by GO-BP analysis. 58 signal pathways including PI3K/Akt and MAPK were enriched by KEGG analysis. Conclusions: In conclusion, our results provide preliminary evidence for the anti-inflammation capacity of MenSCs by regulating microglia polarization. We firstly demonstrated the biological process of factors secreted by MenSCs and the signal pathways involved in using protein array and bioinformatic analysis.
Cation Grease/Brake Rotation in Anionic Pillar[5]arenes and Its Application for Fluorescence Switch
Authors: Zheng Hao , Fu Lulu , Wang Ranran , Jiao Jianmin , Song Yingying , Shi Conghao , Chen Yuan , Jiang Juli , Lin Chen , Ma Jing , Wang Leyong 
Published: September 2022

Abstract
The manual manipulation of motions in molecule level has always been a hot topic in the field of chemistry. Molecular rotors have wide applications in building nanomachines and functional materials, due to their controllable rotations. Hence, it is urgent to develop novel rotor systems with controllable fashions. Differential kinetic traits of planar chirality transformation in sodium carboxylate pillar[5]arene (WP5-Na) and ammonium carboxylate pillar[5]arene (WP5-NH4) were observed serendipitously, which inspired us to construct a promising rotary platform in anionic pillar[5]arenes (WP5) skeletons. Herein, we demonstrate for the first time the nonnegligible effect of counter cations on rotational barriers of hydroquinone rings in WP5, which further exhibit its utilities in establishing a novel and tunable rotor system. Finally, cation grease/brake rotations of WP5 and their applications in fluorescence switch and anti-counterfeiting ink were explored. This study should find potential applications in many aspects, including sensing, molecular devices and stimulus-responsive materials.
A phase Ib trial evaluating the safety, efficacy, and immunologic effects of pembrolizumab plus paclitaxel or flat-dose capecitabine in 1st/2nd line metastatic triple-negative breast cancer
Authors: Page David , Pucilowska Joanna , Chun Brie , Kim Isaac , Sanchez Katherine , Moxon Nicole , Mellinger Staci , Wu Yaping , Koguchi Yoshinobu , Conrad Valerie , Redmond William , Sun Zhaoyu , Martel Maritza , Campbell Mary , Conlin Alison , Acheson Anupama , Basho Reva , McAndrew Philomena , El-Masry Mary , Park Dorothy , Bennetts Laura , Seitz Robert , Nielsen Tyler , McGregor Kimberly , Rajamanickam Venkatesh , Bernard Brady , Urba Walter , McArthur Heather 
Published: September 2022

Abstract
Background

Chemoimmunotherapy with anti-programmed cell death 1/ligand 1 and cytotoxic chemotherapy is a promising therapeutic modality for women with triple-negative breast cancer, but questions remain regarding optimal chemotherapy backbone and biomarkers for patient selection.

Methods

We report final outcomes from a phase Ib trial evaluating pembrolizumab (200mg IV every 3 weeks) with either weekly paclitaxel (80mg/m2 weekly) or flat-dose capecitabine (2000mg orally twice daily for 7 days of every 14-day cycle) in the 1st /2nd line setting. The primary endpoint was safety (receipt of 2 cycles without grade III/IV toxicities requiring discontinuation or ≥ 21-day delays). The secondary endpoint was efficacy (week 12 objective response rate). Exploratory aims were to characterize immunologic effects of treatment over time, and to evaluate novel biomarkers.

Results

Both regimens met the pre-specified safety endpoint (paclitaxel: 87%; capecitabine: 100%). Objective response rate was 29% for pembrolizumab/paclitaxel and 43% for pembrolizumab/capecitabine. Partial responses were observed in two subjects with chemo-refractory metaplastic carcinoma (both in capecitabine arm). Both regimens were associated with significant peripheral leukocyte contraction over time. Response was associated with clinical PD-L1 score, non-receipt of prior chemotherapy, and the H&E stromal tumor infiltrating lymphocyte score, but also by a novel 27 gene IO score and spatial biomarkers (lymphocyte spatial skewness).

Conclusions

Pembrolizumab with paclitaxel or capecitabine is safe and clinically active. Both regimens were lymphodepleting, highlighting the competing immunostimulatory versus lymphotoxic effects of cytotoxic chemotherapy. Further exploration of the IO score and spatial TIL biomarkers is warranted.
Trial registration: NCT02734290
Scalable integration of hybrid high-κ dielectric materials on two-dimensional semiconductors with a van der Waals interface
Authors: Xu Yongshan , Liu Teng , Liu Kailang , Zhao Yinghe , Li Penghui , Liu Lei , Nie Anmin , Liu Lixin , Yu Jun , Feng Xin , Zhuge Fuwei , Li Huiqiao , Wang Xinran , Zhai Tianyou 
Published: September 2022

Abstract
Silicon semiconductor technology is approaching its downscaling limit in state-of-the-art electronics. Atomically thin two-dimensional (2D) semiconductors allow exceptional gate electrostatics in field-effect transistors (FETs), thus holding potential as the candidate channel materials beyond silicon. However, it remains challenging to integrate ultrathin and uniform high-κ dielectrics on 2D materials to fabricate FETs with large gate capacitances, though this is highly required to reduce the device operating voltage toward the energy-efficient electronics. Here we report a versatile two-step approach to integrating high-quality dielectric film with sub-1-nm equivalent oxide thickness (EOT) on 2D materials. Inorganic molecular crystal Sb2O3 is homogeneously deposited on 2D materials as a van der Waals buffer layer, which forms a high-quality oxide-to-semiconductor interface and offers a highly hydrophilic surface, enabling the integration of diverse high-κ dielectrics via atomic layer deposition. Using such an approach, we can fabricate monolayer molybdenum disulfide-based FETs with the ever-reported thinnest EOT (0.67 nm). The transistors exhibit an on/off ratio of over 106 using an ultralow operating voltage of 0.4 V, i.e., an unprecedentedly high gating efficiency not matched by any previous FETs. Our results may pave the way for the applications of 2D materials in the future low-power ultra-scaling electronic devices.