bluuebunny/crossref_metadata_2025_split huggingface dataset:
The positive and negative impacts of the COVID-19 pandemic on the European Council on Chiropractic Education accredited programs: A mixed methods audit and thematic analysis
Authors: Yelverton Christopher , Peterson Cynthia K. , Humphreys B. Kim , Vall Kenneth 
Published: September 2022

ABSTRACT

Objective
The objectives of this study were to: (1) determine the impact of COVID-19 on the operations within the 9 sections of the European Council on Chiropractic Education (ECCE) ‘Standards'; (2) identify specific rapid changes to the programs; and (3) identify positive changes that will continue post-pandemic.

Methods
This was a mixed methods audit and thematic analysis of data from interviews conducted via a cloud-based video conferencing tool with program leaders of the ECCE accredited institutions. A validated questionnaire designed around ECCE's “Standards” was used, consisting of 3 sections: (1) Severity of the COVID-19 impact on each ECCE Standard section; (2) Description of program changes made for each section; (3) Identification of positive changes continuing post-pandemic. Descriptive statistics were calculated for Part 1 and compared for significant differences via the Kruskal-Wallis test. Verbal responses to Parts 2 and 3 were evaluated independently by 3 researchers using a modified “thematic analysis” approach. Final thematic categories and themes were agreed upon by the researchers.

Results
There was a 100% response rate. Outpatient teaching clinics were most severely affected, followed by teaching chiropractic technique courses. Curricular structure and duration and program management were least affected (p =.033). Four thematic categories were identified: Extreme Stress, Courses Most Severely Affected, Integrity of Examinations and Assessments, and Positive Changes That Will Continue.

Conclusion
Final-year students were most negatively impacted due to restricted opportunities in outpatient clinics. Integrity of examinations was also a problem. Positive, innovative teaching materials and methods were quickly developed and should continue.
Study of Genetic Variability, Character Association and Path Analysis in Greengram [Vigna radiata (L.) Wilczek]
Authors: Reddy Punyaswi , Lal Gaibriyal M. , Lavanya G. R. , Reddy Indla Rama Prudhvi 
Published: September 2022

A set of 21 of greengram were evaluated for studying of “Study of Genetic Variability, Character Association and Path Analysis in Greengram [Vigna radiata (L.)Wilczek]”. The experiment was conducted in a Randomized Block Design with three replications during the kharif season, 2021 in the crop research farm of Department of Genetics and Plant Breeding, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj. For all 13 characters, the analysis of variance revealed a significant difference between genotypes. A favourable and very significant link between seed yield per plant and Days to maturity and Harvest Index was found in the current study using both phenotypic and genotypic correlation coefficients. Maximum positive direct effects was depicted by Harvest Index (%), Number of seeds per pod and Plant height (cm) at both phenotypic and genotypic levels. Path analysis further revealed that direct effect of Harvest Index (%), No. of seeds per pod and Plant Height (cm) was of high magnitude. The significant indirect effect through these features also contributed to the high positive relationship of other characters with grain yield per plant (g). This suggested that the above three traits' direct and indirect effects accounted for the majority of the seed yield. As a result, these genotypes may be encouraged for cultivation as well as in next breeding programmes to create better cultivars for sustainable agricultural production.
Foreign Bodies of Airway: Our Experience at a Tertiary Care Center in Gujarat
Authors: Shah Ishita , Bhatt Chandni , Modi Niral 
Published: September 2022

Background: Foreign bodies of airway are a common cause of mortality in pediatric age group. The management of these requires multi-departmental approach. In our study we share our experience of foreign body management over a period of 3 years at a tertiary care center in Gujarat.
Aims: To study incidence, age and gender distribution of foreign bodies in airway; To establish the methods for managing foreign bodies of airway, to study the complications of foreign bodies.
Methods and Management: A prospective study was performed in the department of Otorhinolaryngology in GG. Hospital, Jamnagar, from the year 2018 to 2021. Data was collected for patients with foreign body aspiration.
Results: The most common age group being between 1-2 years of age (48.27%). The mean age in our study was 25.6 months. There was a slight male predilection of 51.72% (n=30), and 48.27% (n= 28) being females. Choking and paroxysmal coughing were the most common symptoms, seen in 68.96% and 77.58% of the patients respectively. Right main bronchus was more commonly affected, 51.72% cases. Peanuts were the most commonly encountered foreign bodies, 58.62%. Laryngeal spasm was the commonest intra operative complication. Post operatively pneumonia was the commonest complication, treated with antibiotics and steroids.
Conclusion: Foreign bodies in the airway are associated with a significantly higher morbidity and mortality. The difficulty in removal of the foreign bodies depends on their location and type, the instruments and the anesthesia available. It continues to pose a challenge even for experienced endoscopists, however, a pre-operative CT scan is extremely helpful.
Influence of Smoking on Disease Activity and Quality of Life in Patients With Rheumatoid Arthritis: Results From a Swedish Case–Control Study With Longitudinal Follow‐Up
Authors: Alfredsson Lars , Klareskog Lars , Hedström Anna Karin 
Published: September 2022

ObjectiveInconclusive findings have been reported regarding the influence of smoking on disease outcomes in established rheumatoid arthritis (RA). This study was undertaken to investigate the influence of smoking habits on disease activity and health‐related quality of life (HRQoL) in RA patients.MethodsPatients with newly diagnosed RA (n = 1,531) from the population‐based case–control Epidemiological Investigation of Rheumatoid Arthritis study were followed up for up to 3 years after recruitment. Using logistic regression models, the risks of unfavorable outcomes in patients with different smoking habits were compared using self‐reported swollen and tender joint counts, the Short Form 36 health survey, the Health Assessment Questionnaire, and the Hospital Anxiety and Depression Scale by calculating odds ratios with 95% confidence intervals.ResultsAt 1‐year and 3‐year follow‐up, current smokers reported higher disease activity and lower HRQoL life compared to non‐smokers, regarding both physical and mental aspects. Patients who stopped smoking within 1‐year post‐baseline had less disease activity measured as swollen joint counts at 1‐year follow‐up compared to those who continued smoking. Patients who stopped smoking after the 1‐year follow‐up had higher disease activity and lower HRQoL at baseline than smokers who did not quit, and late smoking cessation was not associated with more favorable outcomes compared to continued smoking.ConclusionCurrent smoking is associated with increased disease activity and lower HRQoL among RA patients. Smoking cessation within the first year after baseline appears to have a favorable effect on disease activity.
The Synergy of Tensile Strain and Ligand Effect in PtBi Nanorings for Boosting Electrocatalytic Alcohol Oxidation
Authors: Han Sumei , Ma Yuan , Yun Qinbai , Wang An‐Liang , Zhu Qisi , Zhang Hao , He Caihong , Xia Jing , Meng Xiangmin , Gao Lei , Cao Wenbin , Lu Qipeng 
Published: September 2022

AbstractAs the best electrocatalysts for alcohol oxidation reactions in direct alcohol fuel cells (DAFCs), Pt‐based nanomaterials still face the challenges of low utilization efficiency of Pt atoms and poor reaction kinetics. To address these issues, a self‐etching strategy is developed to prepare PtBi nanorings (NRs) with abundant low‐coordinated atoms and inhomogeneous tensile strain (≈4%). The obtained PtBi NRs exhibit superior activity toward methanol oxidation reaction (MOR) and ethanol oxidation reaction (EOR) in alkaline media. Particularly, the mass activities of PtBi NRs for MOR and EOR are 9.4 and 8.5 times higher than those of commercial Pt/C, respectively, which are among the best in the reported Pt‐based catalysts. The highly open structure of PtBi NRs is believed to provide plentiful catalytic active sites and increase the utilization of Pt atoms. Theoretical calculations show that the two important factors, i.e., adsorption energy with the key reaction intermediates and the energy barrier for the potential‐determining step, are significantly optimized owing to the synergy of tensile strain and the ligand effect in PtBi NRs. This study offers a promising strategy for the rational design and preparation of highly efficient catalysts for DAFCs.
Hydrogen‐Bond Reinforced Superstructural Manganese Oxide As the Cathode for Ultra‐Stable Aqueous Zinc Ion Batteries
Authors: Li Jianwei , Luo Ningjing , Kang Liqun , Zhao Fangjia , Jiao Yiding , Macdonald Thomas J. , Wang Min , Parkin Ivan P. , Shearing Paul R. , Brett Dan J.L. , Chai Guoliang , He Guanjie 
Published: September 2022

AbstractLayered manganese oxides adopting pre‐accommodated cations have drawn tremendous interest for the application as cathodes in aqueous zinc‐ion batteries (AZIBs) owing to their open 2D channels for fast ion‐diffusion and mild phase transition upon topochemical (de)intercalation processes. However, it is inevitable to see these “pillar” cations leaching from the hosts owing to the loose interaction with negatively charged Helmholtz planes within the hosts and shearing/bulking effects in 2D structures upon guest species (de)intercalation, which implies a limited modulation to prevent them from rapid performance decay. Herein, a new class of layered manganese oxides, Mg0.9Mn3O7·2.7H2O, is proposed for the first time, aims to achieve a robust cathode for high‐performance AZIBs. The cathode can deliver a high capacity of 312 mAh g−1 at 0.2 A g−1 and exceptional cycling stability with 92% capacity retention after 5 000 cycles at 5 A g−1. The comprehensive characterizations elucidate its peculiar motif of pined Mg‐□Mn‐Mg dumbbell configuration along with interstratified hydrogen bond responsible for less Mn migration/dissolution and quasi‐zero‐strain characters. The revealed new structure‐function insights can open up an avenue toward the rational design of superstructural cathodes for reversible AZIBs.
Impact of edaphoclimatic conditions and crop season on olive oil's fatty acids
Authors: Lechhab Touria , Lechhab Wafae , Trovato Emanuela , Salmoun Farida , Mondello Luigi , Cacciola Francesco 
Published: September 2022

AbstractThe olive tree (Olea europaea L.) fruit oil attracts widespread interest because of its high content of monounsaturated fatty acids. However, a neglected area in the field is the edaphoclimatic factors impact, which is poorly understood. Bearing this in mind, the purpose of this investigation was to evaluate the impact of the edaphoclimatic conditions on the fatty acids’ composition. Therefore, we have investigated the fatty acids methyl ester (FAME) profile in 38 monovarietal Moroccan ‘Picholine Marocaine’ extra‐virgin olive oils (EVOOs) from two successive crop years (2018–2019 and 2019–2020). Significant differences were detected in olive oils from distinct geographical origins with about 10 and 4% of the difference in oleic and palmitic acid amounts in both seasons; however, linoleic acid showed 5 and 8% in 2018–2019 and 2019–2020 oils, respectively. Furthermore, regions of high altitude and low temperature resulted in olive oils rich in oleic acid and monounsaturated fatty acids (MUFAs). This study also revealed the negative impact of rainfall, sand percentage, and nitrogen on saturated fatty acids (SFAs) and of pH and conductivity on the major MUFAs.
Aharonov–Bohm‐Like Flux Effects on the Landauer Conductance in Graphene Wormholes
Authors: Huamaní Jonathan Acuña , Vicente Andrés G. Jirón , Obispo Angel E. , Montero Raul Carita , Castro Luis B. 
Published: September 2022

AbstractIn this work, the graphene wormhole in two cases, i) free case and ii) in the presence of an Aharonov–Bohm (AB)‐like magnetic field are studied. To achieve the objective, the massless Dirac equation is solved in the background of a catenoid metric. As this system does not support exact solutions due to the considered background, the scattering‐state solutions are obtained by means of the Born approximation. In both cases, the Landauer formalism is used to obtain approximate expressions for the conductance. For the free case, a minimum conductance, which is independent of system parameters is found. For the case with an AB‐like magnetic field, the results show that the conductance can be modulated by means of the parameter related to magnetic flux. In addition, a special case where a null magnetic flux generates an oscillatory conductance is analyzed.
On the influence of the amorphous phase on the stability of crystals in poly(cis‐1,4‐isoprene) networks
Authors: Segiet Dominik , Weckes Sebastian , Austermuehl Juergen , Tiller Joerg C. , Katzenberg Frank 
Published: September 2022

AbstractCrosslinked natural rubber and synthetic rubber samples are additivated with up to 9 wt% stearic acid (StA) to better understand the influence of StA on the melting temperature Tm of strain‐induced crystallized poly(cis‐1,4‐isoprene) crystals. To this end, lamellae thicknesses are determined from wide‐angle x‐ray patterns and used to calculate the crystal size dependent melting temperature Tm,calc. Comparing the measured Tm with Tm,calc reveals that Tm deviates downward from Tm,calc and converges Tm,calc with increasing StA concentration until it is identical to Tm,calc, in case of room temperature strain‐induced crystallization. In case of strain‐induced crystallization at 80°C, it was found that Tm is identical with Tm,calc without added StA and deviates upward from Tm,calc with increasing amount of added StA. We suggest that this is due to internal stress onto the polymer crystals exerted by highly strained macromolecules in the surrounding amorphous phase. Whether this stress has a stabilizing or destabilizing effect on the crystals is assumed to depend on its intensity and direction, which can be efficiently altered by the amount and the location of StA crystals in the amorphous phase.
The relationship between formative assessment and reading achievement: A multilevel analysis of students in 19 countries/regions
Authors: Yan Zi , Chiu Ming Ming 
Published: September 2022

AbstractDespite the general consensus on the positive impact of formative assessment on student learning, researchers have not shown the underlying mechanisms between specific formative assessment strategies and academic performance on an international sample. This study examines the link between student and teacher reports of teachers’ formative assessment strategies (i.e. clarifying goals and monitoring progress, providing feedback, and instructional adjustments) and students’ reading achievement, based on data from 151,969 fifteen‐year‐olds in 5,225 schools in 19 countries/regions in PISA 2018 via multilevel analysis of plausible values. The results show that clarifying goals and monitoring progress, and instruction adjustments are positively linked to reading achievement, but providing feedback alone has no significant impact. These findings highlight the complexity of formative assessment as a multifaceted concept and the different impacts of formative assessment strategies on student learning. Implications for researchers and practitioners are discussed.
Synthesis and Characterization of Copper‐Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activities
Authors: Koca‐Caliskan Ufuk , Donmez Ceylan , Eruygur Nuraniye , Ayaz Fatma , Altinkaynak Cevahir , Ozdemir Nalan 
Published: September 2022

AbstractIn this study, organic‐inorganic hybrid nanoflowers were synthesized using methanolic extracts of the medicinal plants Ajuga chamaepitys subsp. chia var. chia, Achillea wilhelmsii, Bongardia chrysogonum, Malva sylvestris, Phlomis grandiflora var. grandiflora, Verbascum sp. together with copper ions (Cu2+). The synthesized plant extract based‐inorganic hybrid nanoflowers (PE‐ihNFs) of A. chamaepitys subsp. chia var. chia (Ac‐ihNFs), A. wilhelmsii (Aw‐ihNfs), B. chrysogonum (Bc‐ihNFs), M. sylvestris (Ms‐ihNFs) P. grandiflora var. grandiflora (Pg‐ihNFs), and Verbascum sp. (Vs‐ihNFs) were characterized by Scanning Electron Microscopy (SEM), Energy‐Dispersive X‐ray (EDX), Fourier transform infrared spectrometry (FTIR), and X‐Ray Diffraction (XRD). Also, several enzymes were selected to evaluate the enzyme inhibition activities of the synthesized PE‐ihNFs. For the first‐time, enzymes, tyrosinase, α‐amylase and α‐glucosidase, acetyl and butyryl cholinesterase inhibition activities of the PE‐ihNFs with comparison to their plain plant extracts were evaluated in vitro. Results show that the among all the analyzed PE‐ihNFs, demonstrated better α‐glucosidase & α‐amylase enzyme inhibition activity compared to the plain extracts. These initial studies are promising for the synthesis of these hybrid nanoflowers containing medicinal plant extracts, which might have commercial applications in the pharmaceutical and dermo‐cosmetics industries.
Diagnosis and treatment of flurbiprofen‐induced Stevens–Johnson syndrome: A rare case report
Authors: Khan Asad Ali , Rashid Farhana , Khan Farhat Ullah , Tahmina Tahmina , Amin Said , Anand Ayush 
Published: September 2022

AbstractOur case highlights the occurrence of severe cutaneous adverse reactions with flurbiprofen use and alerts physicians to its odds with safer drugs.
COVID‐19 co‐infection in a patient with brucellosis
Authors: Shabani Shiva , Ghadimi Saleh 
Published: September 2022

AbstractAn 89‐year‐old male case was hospitalized in the COVID‐19 department. His CT scan showed nodular opacities, also a variable low P O2, elevated transaminases, and a high D‐dimer concentration. The patient diagnosed with active brucellosis. Finally, he treated by combination of doxycycline and rifampicin in addition to anti‐COVID‐19 treatment.
Complete response to intravesical gemcitabine in non‐muscle invasive bladder cancer patient after BCG failure: A case report and literature review
Authors: Nahhat Fouad , Doyya Modar , Ksiri Hazem 
Published: September 2022

AbstractBladder cancer treatment remains a challenge to every oncologist. We report the case of a 57‐year‐old man with BCG‐refractory bladder cancer who had a complete response to intravesical gemcitabine to highlight the role of gemcitabine as a bladder sparing treatment in BCG‐failure patients.
In‐depth proteomic analysis reveals unique subtype‐specific signatures in human small‐cell lung cancer
Authors: Szeitz Beáta , Megyesfalvi Zsolt , Woldmar Nicole , Valkó Zsuzsanna , Schwendenwein Anna , Bárány Nándor , Paku Sándor , László Viktória , Kiss Helga , Bugyik Edina , Lang Christian , Szász Attila Marcell , Pizzatti Luciana , Bogos Krisztina , Hoda Mir Alireza , Hoetzenecker Konrad , Marko‐Varga György , Horvatovich Peter , Döme Balázs , Schelch Karin , Rezeli Melinda 
Published: September 2022

AbstractBackgroundSmall‐cell lung cancer (SCLC) molecular subtypes have been primarily characterized based on the expression pattern of the following key transcription regulators: ASCL1 (SCLC‐A), NEUROD1 (SCLC‐N), POU2F3 (SCLC‐P) and YAP1 (SCLC‐Y). Here, we investigated the proteomic landscape of these molecular subsets with the aim to identify novel subtype‐specific proteins of diagnostic and therapeutic relevance.MethodsPellets and cell media of 26 human SCLC cell lines were subjected to label‐free shotgun proteomics for large‐scale protein identification and quantitation, followed by in‐depth bioinformatic analyses. Proteomic data were correlated with the cell lines’ phenotypic characteristics and with public transcriptomic data of SCLC cell lines and tissues.ResultsOur quantitative proteomic data highlighted that four molecular subtypes are clearly distinguishable at the protein level. The cell lines exhibited diverse neuroendocrine and epithelial–mesenchymal characteristics that varied by subtype. A total of 367 proteins were identified in the cell pellet and 34 in the culture media that showed significant up‐ or downregulation in one subtype, including known druggable proteins and potential blood‐based markers. Pathway enrichment analysis and parallel investigation of transcriptomics from SCLC cell lines outlined unique signatures for each subtype, such as upregulated oxidative phosphorylation in SCLC‐A, DNA replication in SCLC‐N, neurotrophin signalling in SCLC‐P and epithelial–mesenchymal transition in SCLC‐Y. Importantly, we identified the YAP1‐driven subtype as the most distinct SCLC subgroup. Using sparse partial least squares discriminant analysis, we identified proteins that clearly distinguish four SCLC subtypes based on their expression pattern, including potential diagnostic markers for SCLC‐Y (e.g. GPX8, PKD2 and UFO).ConclusionsWe report for the first time, the protein expression differences among SCLC subtypes. By shedding light on potential subtype‐specific therapeutic vulnerabilities and diagnostic biomarkers, our results may contribute to a better understanding of SCLC biology and the development of novel therapies.
Pleural metastasis from parotid secretory carcinoma: First report of morphology on effusion cytology, and role of pan‐TRK immunohistochemistry
Authors: Mahendru Ria , Kakkar Aanchal , Cipriani Nicole Anne , Sarma Chetna , Ghosh Vivek , Kaur Kavneet , Gupta Subhash , Mohan Anant 
Published: September 2022

AbstractDistant metastasis from salivary gland secretory carcinoma (SC) is rare, with lung and pleura being the most frequent site. While cytological features of SC on fine needle aspirates are well documented, its morphology in serous effusions has not been described. We describe the cytomorphological features on effusion cytology of two patients with ETV6::NTRK3 fusion‐positive SC, who subsequently developed pleural metastases. Cytospin preparations of pleural fluid showed tightly cohesive, irregularly shaped and ball‐like clusters of large tumor cells with scant to abundant uni‐ and multi‐vacuolated cytoplasm. Nuclei were eccentrically placed, round to oval, vesicular, with finely granular chromatin, irregular nuclear membranes and conspicuous to prominent nucleoli. With these features, the tumors resembled an adenocarcinoma, indistinguishable from a lung primary. Cell blocks from both cases showed tumor fragments, some of which had the hollow appearance of transversely sectioned cell spheres as seen in lung and breast adenocarcinomas. Immunohistochemistry on cell blocks revealed nuclear pan‐TRK positivity in both cases. Case 1 also showed focal mammaglobin staining, and TTF1 negativity. Pleural metastases from SC may mimic other adenocarcinomas. As targeted therapy, that is, selective TRK inhibitors are available for treatment of metastatic disease, NTRK3 fusion status is not only diagnostic, but also required to plan treatment. Pan‐TRK immunohistochemistry serves as a viable cost‐effective, easy to apply surrogate marker for NTRK3 fusion, particularly in diagnostic laboratories lacking easy access to molecular testing on cytological material.