bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic inflammatory bowel diseases and sexuality: Inevitable disorders?
Authors: Charfi N. , Guermazi A. , Guermazi F. , Omri S. , Smaoui N. , Feki R. , Thabet J. Ben , Zouari L. , Bouali M. Maalej , Tahri N. , Boudabous M. , Maalej M. 
Published: February 2022

IntroductionImproving the quality of sexual life of patients has become a major therapeutic objective in the management of Chronic Inflammatory Bowel Diseases (CIBD).ObjectivesTo assess the prevalence of sexual dysfunction (SD) in patients with CIBD in remission and compare it to healthy controls (HC), and to determine the associated factorsMethodsThis was a cross-sectional study, conducted over 8 months, involving 36 patients with CIBD, who attended the gastroenterology outpatient of Hedi Chaker University Hospital in Sfax (Tunisia). They were compared to 36 HC. Sexual function was assessed with the “Female sexual Function Index” and the “International Index of Erectile Function”.ResultsIn the sample of CIBD, the prevalence of SD was 65.4% in women and 50% in men. Compared to controls, patients with male gender had significantly more impaired erection and orgasm (p=0.005; p=0.002 respectively), and those with female gender had significantly more impaired sexual arousal and desire (p=0.003; p=0.028 respectively). In the sample of patients, having a poor marital harmony and a fewer sexual attraction towards partner were correlated with decreased desire (p=0.017) in men and with sexual arousal (p=0.024) and decreased desire (p=0.048) in women. The number of relapses negatively affects erection (p=0.038) and orgasm (p=0.048). Depression correlated with a decreased orgasm (p=0.001) and desire (p=0.048) in men, and with a decreased sexual arousal (p=0.006) in women.ConclusionsSD is common in CIBD, hence the need for a multidisciplinary approach to allow improvement of the quality of life of these patients, and of their partners.
Antidepressants effect on sexual dysfunction in men with PTSD
Authors: Maalej R. , Hamdi G. , Felfel D. , Ammar H. Ben , Kissi Y. El , Maamri A. , Zalila H. 
Published: February 2022

IntroductionVarious therapeutic approaches for post-traumatic stress disorder have been the subject of numerous studies. Antidepressants are sometimes used in PTSD. They improve the symptoms of PTSD. But their effect is not clear on the sexual dysfunctions that accompany this disorder.ObjectivesThe aim of this study is to display the effect of antidepressants on sexual dysfunctions in men with PTSD.MethodsA total of 30 male patients with PTSD were included in this study. The International Erectile Function Index (IIEF15) was used to assess sexual dysfunction in participants before treatment and two months after starting antidepressant treatment.ResultsHalf of the patients (50%) used sertraline, 23% paroxetine, 20% fluoxetine and 7% escitalopram.The mean IIEF-15 score was 51.16 ± 6.82 in patients with PTSD before initiation of treatment. The average scores of the areas of sexuality studied by this scale were 3.93 ± 0.52 for sexual desire; 18.80 ± 5.68 for erectile function; 8.93 ± 8.97 for orgasmic function; 5.13 ± 1.10 for satisfaction with intercourse and 4.13 ± 1.16 for overall satisfaction. After 2 months of use of the antidepressant treatment, there was a statistically significant improvement in sexual functions: significant increase in the total score of the IIEF15 (p <0.001), and in the mean scores of the areas of sexuality.ConclusionsAntidepressant treatment could, by improving post-traumatic symptoms, improve sexual dysfunction.
Sleep quality, sensory processing abilities and work performance for adults with attention deficit hyperactive disorder
Authors: Grinblat N. , Rosenblum S. 
Published: February 2022

IntroductionPoor sleep quality has been reported among adults with attention-deficit hyperactive disorder (ADHD) and has been associated with reduced sensory-processing abilities and low work performance. However, the relationships among sleep quality, sensory processing and the insufficient work performance of adults with ADHD is still unclear.ObjectivesFollowing the World Health Organization’s international classification of functioning, disability and health concepts, this study compares sleep quality and sensory processing (body functions) and work performance (participation) of adults with ADHD to those of controls, and examines the relationships among those components in adults with ADHD.MethodsParticipants were 69 adults with ADHD and 52 age- and gender-matched controls. All completed a sociodemographic questionnaire, the Mini Sleep Questionnaire, the Adult/Adolescent Sensory Profile and the Occupational Questionnaire.ResultsCompared to controls, the adults with ADHD showed significantly poorer body functions (sleep quality and sensory processing patterns) and lower work performance. Significant correlations were found between sleep quality and sensory-processing abilities and between sleep quality and work performance among adults with ADHD. Regression analysis revealed that for adults with ADHD, sleep quality accounted for 22.0%, and sensory sensitivity accounted for 10.9%, of the variance of their work performance.ConclusionsSleep quality, together with sensory processing patterns, has a significant influence on work performance of adults with ADHD. Because work is a vital occupation for adults, these body functions need to be considered in clinical settings, and further research on this topic is required for better understanding of the phenomena.KeywordADHD add Sleep quality add work performance add sensory processing
Sleep and personality in college students: A preliminary study
Authors: Amaral A.P. , Fernandes C. , Pocinho M. 
Published: February 2022

IntroductionSleep represents an important process in the stable behavioural and emotional functioning of the individual and is an important health indicator. Personality is related with academic and occupational achievement, quality of interpersonal relationships, but also with sleep. Concerning personality, individuals with lower emotional stability have greater sensitivity to stress and maladaptive sleep-related behaviour.ObjectivesThe main goal of this study is to analyze the relation between sleep quality and personality in college students.MethodsThis study employed a correlational design. A sample of 220 Portuguese students (84.9% females), with mean age of 19.5 years (sd=3.4), from different health courses, filled in the Pittsburgh Sleep Quality Questionnaire and HEXACO-60, during a single individual session. A descriptive statistical analysis, a Pearson correlation analyses and the t Student test, for independent samples, were performed.ResultsThe results showed a predominance of poor sleep quality among students (96.3%). The more prevalent HEXACO dimensions are: Conscientiousness (X=32.6; sd=4.2) and Emotionality (X=31.2; sd=5.2). When exploring personality differences between sleep groups (GSG=Good Sleep Group; PSG=Poor Sleep Group) a significant difference was found in mean scores of the dimension Emotionality. It was observed that the PSG revealed higher levels of Emotionality than the GSG (PSG=31.5; sd=5.1; PSG=26.3; sd=4.0; p<.05).ConclusionsCollege students self-report a poor sleep and the prevalent personality dimensions are Conscientiousness and Emotionality. Students with higher levels of Emotionality (fearfulness, anxiety, dependence and sentimentality) presented a poor sleep. To conclude, mediation studies are needed in order to better understanding the link between personality and sleep.
Chronic upregulation of circadian clock protein per1 among OSA patients
Authors: Gabryelska A. , Sochal M. , Bialasiewicz P. 
Published: February 2022

IntroductionPER1 is a repressor protein involved in regulating circadian rhythm. While obstructive sleep apnea (OSA) is characterized by recurred pauses in breathing caused by the collapse of the upper airways it might be associated with disruption of the circadian clock.ObjectivesThe study aimed to assess PER1 protein in OSA patients and evaluate its association with PSG parameters.MethodsThe study included 40 individuals, who underwent diagnostic polysomnography (PSG) examination. Based apnea-hypopnea index (AHI) patients were divided into groups: control (AHI<5; n=10) and OSA (AHI5; n=30). All participants had their peripheral blood collected in the evening (9:00-10:00 pm) before and in the morning (6:00-7:00 am) after the PSG. PER1 protein concertation measurements were performed using ELISA. Funding: National Science Centre, Poland-2018/31/N/NZ5/03931.ResultsThe control and OSA group were match in sex and age, while differed regarding BMI (p=0.039), desaturation index (p<0.001) and AHI (p<0.001). PER1 protein level was elevated in OSA group compared to control both in the evening (322.384.1vs.208.460.1pg/ml;p<0.001) and morning (314.891.9vs.228.157.3pg/ml;p=0.002). No difference was observed between evening and morning PER1 level (p=0.946). Morning PER1 correlated with AHI (r=0.400; p=0.011), desaturation index (r=0.391;p=0.013), age (r=-0.312;p=0.049) and BMI (r=0.383;p=0.015). In a multiple linear regression model (R2=0.268;p=0.003) morning PER1 protein level was influenced by age (p=0.006) and AHI (p=0.025), while BMI and desaturation index were not significant.ConclusionsOSA patients might suffer from circadian clock disruption, which is mainly associated with the severity of the disorder and age. Further studies are needed as this dysregulation can result in metabolic and mood disorders often observed in this group of patients.
Parental postpartum affective disorders as a risk factor for infant bedtime resistance
Authors: Ragni B. , De Stasio S. , Capitello T. Grimaldi , Giampaolo R. , Gentile S. 
Published: February 2022

IntroductionInfant intrinsic factors, parental mental health, and parenting functioning could influence infant sleep development (Camerota et al., 2019). The current study was designed to advance understanding of parental mental health in influencing bedtime resistance in infants aging 8-12 months.ObjectivesThe main aim of the present study was to examine the role of parental postpartum affective disorders, infants’ temperament and paternal involvement at bedtime in predicting infants’ bedtime resistance (e.g. fussing, crying or protesting).Methods60 Italian families of infants (34 boys and 26 girls) aging from 8 to 12months (M =10.73, SD = 2.54) participated in this study. Parents completed Brief Infant Sleep Questionnaire (Sadeh et al., 2009), Perinatal Assessment of Paternal and Maternal Affectivity (Baldoni et al., 2018), QUIT for infants’ temperament (Axia, 2002) and an ad-hoc questionnaire for fathers’ involvement. Two multiple linear regressions (MR), one for fathers and one for mothers, and relative weight analyses (RWA) were conducted.ResultsInfants’ involvement in constant bedtime routines (reported by fathers: β = −.35, p < .05; mothers: β = −.31, p < .05) and paternal involvement at bedtime (fathers: β = −.45, p < .01; mothers: β = −.27, p < .05) represented protective factors for infants’ bedtime difficulties. Paternal affective disorders, accounted for 17.2% of the explained variance for mothers’ and 12.5% for fathers’ reports of infant bedtime difficulties, more than did maternal postpartum affective disorders.ConclusionsFindings support that parental mental health can interfere with infants’ bedtime resistance.
Is ADHD a sleep disorder? can adhd improve by treating the comorbid sleep disorder(S)? a research update
Authors: Kooij J.J.S. 
Published: February 2022

IntroductionResearch has shown that ADHD and sleep disorders are intimately intertwined in the majority of patients in both childhood and adulthood. Circadian rhythm sleep disturbances, esp. the delayed sleep phase syndrome, as well as several other sleep disorders, such as Insomnia, Restless Legs, Periodic Limb Movement Disorder and Sleep apnea are associated with ADHD. With a prevalence rate of 80% of sleep disorders in adults with ADHD, the question not only is what is chicken and egg, but even if both conditions share a joint pathophysiology.ObjectivesTo investigate the consequences of this comorbid sleep disorders on severity of ADHD, mood and health, as well as to find evidence on improvement of ADHD by treatment of the sleep disorder(s).MethodsRecent research will be evaluated to formulate answers to these questions.ResultsSleep loss resulting from sleep disorders increases ADHD severity due to more impairment of cognition and memory as well as mood instability. Sleep loss in the longer term also leads to obesity, with negative consequences for health in general. First studies showing a decrease of ADHD symptoms by treatment of sleep disorders will be discussed.ConclusionsADHD and sleep disorders come together in the majority of patients and need both assessment and treatment. Treatment of ADHD by improving sleep, is an intriguing research question with potential new treatment options.
Elderly: Coping with sleep disorders
Authors: Silva D. , Martins R. , Polido F. , Cruz M.D.C. 
Published: February 2022

IntroductionSleep problems are a common presenting symptom of elderly patients to Primary care physicians and Psychiatrists. Almost half of seniors over age 65 who live at home are dissatisfied with their sleep, and nearly two-thirds of those residing in nursing home facilities suffer from sleep disorders. Chronic and pervasive sleep complaints and disturbances are frequently associated with excessive daytime sleepiness and may result in impaired cognition, diminished intellect, poor memory, confusion, and psychomotor retardation.ObjectivesThe aim of this article is to sumarize and explore the facts envolving sleep disorders, discusses approaches to treatment and highlights new research in the area of geriatric sleep disorders.MethodsAn online bibliographic search was carried out on PubMed and Medline using the keywords “Elderly”, “sleep” and “Psychiatry”.ResultsManagement of sleep disorders is complicated by the risk of side effects of pharmacologic treatment approaches, and thus nonpharmacologic strategies are preferred when possible. Additionally, many of the pharmacologic strategies used in treating younger adults have not been studied adequately in the geriatric population, and more specifically in patients with underlying cognitive disorders, making treatment choices difficult.ConclusionsThis review has provided insights into the biopsychosocial impact of sleep disorders in the elderly, as this group pose unique challenges for diagnosis and treatment. Sleep changes in the elderly may have a far broader impact on geriatric health than originally thought, with implications for AD and delirium, and further research is needed in these areas as well.
Sleep problems in opioid dependent patients maintained on buprenorphine
Authors: Tripathi R. , Rao R. , Dhawan A. , Jain R. 
Published: February 2022

IntroductionOpioid dependent individuals frequently complain of sleep problems in withdrawal and during abstinence.ObjectivesThe objectives were to assess the subjective sleep parameters among buprenorphine-maintained opioid-dependent patients and to correlate it with socio-demographics, concomitant drug use and treatment related variablesMethodsUsing a cross-sectional study design, 106 hundred six opioid-dependent patients maintained on buprenorphine for at least six months and on same dose in past month were interviewed. Sleep was assessed by Pittsburgh sleep quality index (PSQI) and Epworth sleepiness scale. Association between subjective sleep parameters, socio-demographics, concomitant drug use and treatment related variables was also studied.ResultsAll participants were males. Their mean age was 41.1 years (SD:14.3). The mean duration of illicit opioid use was 10 years (IQR: 5,22). About 63.2% (n=67) had PSQI scores more than 5 denoting sleep problem. The scores obtained in Epworth Sleeping Scale were in normal range. Mean subjective total sleep time of the sample was 403.5 (SD 94.8) minutes and median sleep latency was 35 (IQR 18.8, 62.5) minutes. Subjective total sleep time was significantly higher in participants who had use tobacco in the past three months (p value=0.03) and who were in moderate ASSIST risk category (p value=0.04). Subjective sleep latency was significantly higher (p value=0.04) in participants who had used opioids in last three months. It was observed that age was a significant predictor of subjective total sleep time and OST compliance was a significant predictor of sleep latency.ConclusionsA sizeable proportion of opioid dependent patients on buprenorphine have sleep problems
A mixed-methods analysis of patient safety incidents involving opioid substitution treatment with methadone or buprenorphine in community-based care in England and Wales
Authors: Gibson R. , Macleod N. , Donaldson L. , Williams H. , Sheikh A. , Carson-Stevens A. 
Published: February 2022

IntroductionThere is a paucity of knowledge and understanding of medical error in opioid substitution treatment programmes.ObjectivesTo characterise patient safety incidents involving opioid-substitution treatment with methadone or buprenorphine in community-based care to identify the sources and nature of harm, describe and interpret themes and use this qualitative analysis to identify priorities to focus future improvement work.MethodsWe undertook a mixed-methods study examining incidents involving opioid substitution treatment with methadone or buprenorphine in community-based care submitted between 2005 and 2015 from the National Reporting and Learning System, a repository of incident reports from England and Wales. We analysed each report using four frameworks to identify incident type, contributory factors, incident outcome and severity of harm. Analysis involved detailed data coding and iterative generation of data summaries using descriptive statistical and thematic analysis.Results2,284 reports were identified. We found that most risks of harm came from failure in one of four processes of care delivery: prescribing opiate-substitution (n=151); supervised dispensing errors (n=248); non-supervised dispensing errors (n=318); and monitoring and communication activities (n=1544). Most incidents resulting in harm involved supervised or non-supervised dispensing (n=91/127, 72%). Staff- (e.g. mistakes, not following protocols) and organisation-related (e.g. poor working conditions or poor continuity of care between services) contributory factors were present for over half of incidents.ConclusionsWe have identified four processes of care delivery and associated contributory factors, which represent potential target areas for healthcare systems worldwide to develop interventions to improve the safe delivery of opioid substitution treatment.
Assessing altered executive functioning in substance use disorder: Evidence from a novel neurocognitive screening battery
Authors: Balconi M. , Losasso D. , Balena A. , Crivelli D. 
Published: February 2022

IntroductionRecently, clinical models based on neuroscientific evidence have highlighted the detrimental role of executive functions impairments in negatively contributing to the functional decline of patients with Substance Use Disorder (SUD). Yet, despite these potential implications, the screening tools that are typically used to assess such impairments are not specific for patients presenting addiction and are not able to properly sketch their dysfunctional executive control profile.ObjectivesThis study aimed at testing the clinical potential of a novel screening battery for neurocognitive disorders in addiction.MethodsThe screening battery was tested on 151 patients with SUD and 55 control subjects. The battery consisted of five neuropsychological tests tapping on verbal and working memory, focused attention, and cognitive flexibility and two computerized neurocognitive tasks (Stroop and Go/No-go tasks adapted for the evaluation of interference inhibition, executive control, and attention bias towards drugs of abuse).ResultsStatistical analyzes showed worse cognitive performance in patients with SUD compared to controls, both at neuropsychological tests of cognitive flexibility, focused attention and verbal memory and at neurocognitive tasks, suggesting the presence of deficit of regulatory mechanisms involved in inhibition and orientation of attention/cognitive resources. These results were also confirmed by second-level analyses where the role of age and education as potential moderators was checked, suggesting the robustness of the tested measures.ConclusionsThe results further stress the link between specific executive impairments and SUD and suggest the potential of the battery as a quick yet valid neurocognitive screening tool.
Ethnic differences in the prevalence of online behaviors in adolescents in the southern regions of siberia
Authors: Semenova N. , L L. Evert , Kostyuchenko Y. , Tereshchenko S. 
Published: February 2022

IntroductionAn urgent problem all over the world is the growing number of adolescents with maladaptive (Internet addicted) Internet use.ObjectivesTo study the prevalence of various types of online behavior in adolescents in the southern regions of Siberia (Caucasians and Mongoloids).Methods4351 adolescents aged 12-18 in the city of Krasnoyarsk and the city of Abakan (Republic of Khakassia) were surveyed. Ethnicity is determined by the nationality of the mother. Online behavior was studied using the Chen Internet Addiction Scale (CIAS): adaptive internet use (API) – 27-42 points, non-adaptive (NPI) – 43-64 points and pathological (PPI) ≥ 65 points. The indicators were compared in 2 groups: Caucasians and Mongoloids. The program “Statistica 12” was used, the percentage of the share, the significance of the differences (p) and the values of the Pearson χ2 test were indicated.ResultsCaucasians by their mothers accounted for 3663 (84.2%) and the share of Mongoloids reached 688 (15.8%). AIP was recorded in 44.0% of Caucasians and 7.9% of Mongoloids (p <0.0001; χ2 = 1474.99), NPI was recorded in 34.7% of Caucasians and 6.2% of Mongoloids (p <0.0001; χ2 = 1084.65), PPI was found in 5.5% of Caucasians and 1.7% of Mongoloids (p <0.0001; χ2 = 90.49).ConclusionsEthnic features of the prevalence of online behavior in adolescents in the southern regions of Siberia include a higher frequency of NPI and PPI in Caucasians compared to Mongoloids. The reported study was funded by RFBR according to the research project № 18-29-22032\18.Conflict of interestThe reported study was funded by RFBR according to the research project № 18-29-22032\18.