bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health care transition planning: A potpourri of perspectives from nurses
Authors: Betz Cecily L. , Mannino Jennifer E. , Disabato Jennifer A. , Marner Victoria 
Published: April 2022

PurposeNurses have important roles as members of the healthcare transition (HCT) planning interdisciplinary team. Nursing's scope of practice and framework of care brings a distinctive and complementary approach to this expanding field in pediatric care. It is therefore relevant to better understand the extent to which pediatric nurses are involved with the provision of HCT services and model development.Design and MethodsThis was a qualitative analysis of a national survey of pediatric nurses. A thematic iterative process was used to code data. Three coders separately analyzed responses and then met to compare and discuss until a final list of codes was achieved. The codes were further analyzed until themes and subthemes emerged. Throughout the process, disagreements were discussed and resolved until consensus was achieved.ResultsA sample of 1814 pediatric nurses and nurse practitioners from two US professional organizations participated in this national survey to gather data on their involvement in HCT planning. This survey contained 17 items, one of which was an open‐ended question stating: Is there anything else you would like to share about your role with the population of transitioning youth and young adults with chronic illness and/or disability? The analysis of responses provided by 154 nurses is presented. Initial coding resulted in 11 categories of data. Four major themes, including four subthemes, emerged from the analysis of responses: Support for the need for transition (subtheme: Nursing involvement); Guidance needed for professional practice (subtheme: Types of guidelines and training); Lack of service linkages to adult providers; and Difficulty letting go (two subthemes: Pediatric providers; Parents).Practice ImplicationsThese findings indicated strong support for the need of HCT services and the importance of nursing involvement. However, challenges to HCT implementation were identified that include systemic, psychosocial, and educational barriers. As this field of practice and research continues to grow, it is important that pediatric nurses recognize the opportunities to have a clinical voice to develop nurse‐led HCT services and programs.
Sounds and associated morphology of Hypostomus species from South‐East Brazil
Authors: Raick X. , Koussa A. , Zawadzki C. H. , Kurchevski G. , Godinho A. L. , Parmentier É. 
Published: April 2022

AbstractHypostomus is the most diverse genus within Loricariidae. These catfish species exhibit a very conservative morphology with relatively few external characteristics that differ between different species. In consequence, there is a challenge to understand the distinction of species of this genus. This study aims to describe the sounds produced by ten species of Hypostomus from Araguari River and Paraopeba River (Minas Gerais, Brazil), to examine whether acoustic features could be used to distinguish between the species, and to understand the corresponding sound production mechanisms. The fish were recorded making sounds by holding them in hand underwater, in a glass tank on the river shore next to where they had been caught. All ten species produced sounds, and no effect of body size on acoustic features was observed. Furthermore, the species could not be distinguished using acoustic features. Likewise, all the studied species exhibited similar bony ridges on the dorsal processes of the pectoral spine. Since the sounds produced by the fish do not seem to exhibit interspecific specificity, they do not appear to have a role in behaviours requiring conspecific recognition, such as reproduction. Sound production may have an alarm, distress, or acoustic aposematism function warning predators of the presence of pectoral spines, which have an anti‐predatory function in this clade.
Unpacking value destruction at the intersection between public and private value
Authors: Cui Tie , Osborne Stephen P. 
Published: April 2022

AbstractPublic services do not always create value. Rather, when poorly organized and/or delivered, they can destroy value and make service users' lives worse. However, such “value destruction” is presently weakly conceptualized in public management theory. Consequently, this paper is devoted to the empirical examination of value destruction and hence its conceptualization. At the heart of the paper, we recognize the multiplicity of public value and private value objectives in complex public service environments and the dyadic tension between these two value constellations. Drawing upon qualitative data derived from public carbon reduction projects, we establish a conceptual framework. This framework accounts both for the types of value destruction and for the tension between public and private value. Subsequently, the framework disentangles the value destruction concept into four categories: value ignorance, value disproportion, value backlash, and value exploitation. Finally, the implications of this new conceptual framework for public management theory and practice are explored.
Longitudinal asthma exacerbation phenotypes in the Korean childhood asthma study cohort
Authors: Park Ji Soo , Suh Dong In , Song Dae Jin , Baek Hey‐Sung , Shin Meeyong , Yoo Young , Kwon Ji‐Won , Jang Gwang Cheon , Yang Hyeon‐Jong , Lee Eun , Kim Hwan Soo , Seo Ju‐Hee , Woo Sung‐Il , Kim Hyung Young , Shin Youn Ho , Lee Ju Suk , Yoon Jisun , Jung Sungsu , Han Minkyu , Eom Eunjin , Yu Jinho , Kim Woo Kyung , Lim Dae Hyun , Kim Jin Tack 
Published: April 2022

AbstractBackgroundAsthma exacerbation (AE) leads to social and economic costs and long‐term adverse outcomes. We aimed to predict exacerbation‐prone asthma (EPA) in children.MethodsThe Korean childhood Asthma Study (KAS) is a prospective nationwide pediatric asthma cohort of children aged 5–15 years followed every 6 months. Patients with AE during the 6 months prior to all three visits, with AE prior to one or two visits, and without AE prior to any visit were defined as having EPA, exacerbation‐intermittent asthma (EIA), and exacerbation‐resistant asthma (ERA), respectively. Risk factors and prediction models of EPA were explored.ResultsOf the 497 patients who completed three visits, 42%, 18%, and 15% had exacerbations prior to visits 1, 2, and 3 and 5%, 47%, and 48% had EPA, EIA, and ERA, respectively. Univariate and multivariable logistic regression revealed forced expiratory volume in 1 s (FEV1) z‐score, forced vital capacity (FVC) z‐score, white blood cell (WBC) count, and asthma control test (ACT) score as relevant EPA risk factors. The EPA prediction model comprised FVC z‐score, WBC count, ACT score, sex, and parental education level (area under the receiver operating characteristic curve [AUROC] 0.841 [95% confidence interval (CI): 0.728–0.954]).ConclusionWith appropriate management, AE decreases over time, but persistent AEs may occur. Apart from asthma control level, baseline lung function and WBC count predicted EPA.
Initial attendance and retention in adult healthcare as criteria for transition success among organ transplant recipients
Authors: Rea Kelly E. , Cushman Grace K. , Quast Lauren F. , George Roshan P. , Basu Arpita , Ford Ryan , Book Wendy , Blount Ronald L. 
Published: April 2022

AbstractBackgroundAdolescent and young adult (AYA) solid organ transplant recipients experience worsening medical outcomes during transition to adult healthcare. Current understanding and definitions of transition success emphasize first initiation of appointment attendance in adult healthcare; however, declines in attendance over time after transfer remain possible, particularly as AYAs are further removed from their pediatric provider and assume greater independence in their care.MethodsThe current study assessed health‐care utilization, medical outcomes, and transition success among 49 AYA heart, kidney, or liver recipients recently transferred to adult healthcare. Differences in outcomes were examined along two transition success criteria: (1) initial engagement in adult healthcare within 6 or 12 months of last pediatric appointment and (2) retention in adult healthcare over 3 years following last pediatric appointment. Growth curve modeling examined change in attendance over time.ResultsSuccessful retention in adult healthcare was significantly related to more improved clinical outcomes, including decreased number and duration of hospitalizations and greater medication adherence, as compared to initial engagement. Significant declines in appointment attendance over 3 years were noted, and individual differences in declines were not accounted for by age at transfer or time since transplant.ConclusionsFindings underscore support for AYAs after transfer, as significant declines in attendance were noted after initiating adult care. Clinical care teams should examine transition success longitudinally to address changes in health‐care utilization and medical outcomes. Attention to interventions and administrative support aimed at maintaining or increasing attendance and identifying risk factors and intervention for unsuccessful transition is warranted.
“What matters to you?”: The relevance of patient priorities in dialysis care for assessment and clinical practice
Authors: Tommel Judith , Evers Andrea W. M. , van Hamersvelt Henk W. , Jordens Rien , van Dijk Sandra , Hilbrands Luuk B. , Hermans Marc M. H. , Hollander Daan A. M. J. , van de Kerkhof Jos J. , ten Dam Marc A. G. J. , van Middendorp Henriët 
Published: April 2022

AbstractBackgroundDialysis patients are confronted with numerous, complex problems, which make it difficult to identify individual patient's most prominent problems. The objectives of this study were to (1) identify dialysis patients' most prominent problems from a patient perspective and (2) to calculate disease‐specific norms for questionnaires measuring these problems.MethodsOne hundred seventy‐five patients treated with hemodialysis or peritoneal dialysis completed a priority list on several domains of functioning (e.g., physical health, mental health, social functioning, and daily activities) and a set of matching questionnaires assessing patient functioning on these domains. Patient priorities were assessed by calculating the importance ranking of each domain on the priority list. Subsequently, disease‐specific norm scores were calculated for all questionnaires, both for the overall sample and stratified by patient characteristics.ResultsFatigue was listed as patients' most prominent problem. Priorities differed between male and female patients, younger and older patients, and home and center dialysis patients, which was also reflected in their scores on the corresponding domains of functioning. Therefore, next to general norm scores, we calculated corrections to the general norms to take account of patient characteristics (i.e., sex, age, and dialysis type).ConclusionsResults highlight the importance of having attention for the specific priorities and needs of each individual patient. Adequate disease‐specific, norm‐based assessment is not only necessary for diagnostic procedures but is an essential element of patient‐centered care: It will help to better understand and respect individual patient needs and tailor treatment accordingly.
Expectation of irrelevant novel stimuli has no consistent effect on recognition memory
Authors: Reichardt Richárd , Simor Péter , Polner Bertalan 
Published: April 2022

Novelty is defined as the part of an experience that is not yet represented by memory systems. Novelty has been claimed to exert various memory‐enhancing effects. A pioneering study by Wittmann et al. (2007) has shown that memory formation may even benefit from the expectation of novelty. We aimed to replicate this assumed memory effect in four behavioral studies. However, our results do not support the idea that anticipated novel stimuli are more memorable than unexpected novelty. In our experiments, we systematically manipulated the novelty predicting cues to ensure that the expectations were correctly formed by the participants, however, the results showed that there was no memory enhancement for expected novel pictures in any of the examined indices, thus we could not replicate the main behavioral finding of Wittmann et al. (2007). These results call into question the original effect, and we argue that this fits more into current thinking on memory formation and brain function in general. Our results are more consistent with the view that unexpected stimuli are more likely to be retained by memory systems. Predictive coding theory suggests that unexpected stimuli are prioritized by the nervous system and this may also benefit memory processes. Novel stimuli may be unexpected and thus recognized better in some experimental setups, yet novelty and unexpectedness do not always coincide. We hope that our work can bring more consistency in the literature on novelty, as educational methods in general could also benefit from this clarification.
Understanding how child temperament, negative parenting, and dyadic parent–child behavioral variability interact to influence externalizing problems
Authors: Brown Kayla M. , Pérez‐Edgar Koraly , Lunkenheimer Erika 
Published: April 2022

AbstractTo better understand the development of externalizing behavior, the current study examines how multiple levels of influence (child temperament, negative parenting, and dyadic interactions) work together to increase externalizing behaviors over time. Negative parenting (NP) and observed dynamic dyadic behavioral variability (DBV) in parent–child interactions (e.g., in discipline and compliance) are characteristic of coercive family processes. The present study first examined latent profiles of temperament in 3‐year‐olds (N = 150). Four temperament profiles emerged: high reactive, exuberant, low reactive, and inhibited. Temperament profiles were then examined as moderators of the effects of the age of three NP and DBV on child externalizing problems at the age of four. Exuberant temperament exacerbated the association between higher levels of NP and DBV and higher levels of child externalizing. Additionally, temperament moderated the combined effects of NP and DBV such that at low and mean levels of NP, children with exuberant temperaments who experienced higher DBV had higher externalizing behaviors, whereas at higher levels of NP, the influence of DBV was no longer significant. Results suggest pathways by which children's experiences of NP and DBV with parents contribute to their greater externalizing problems over time, in the context of the child's unique temperament profile.
Transfer of carbon incubation parameters to model the SOC and SON dynamics of a field trial with energy crops applying digestates as organic fertilizers
Authors: Gasser S. Anton A. , Nielsen Kerstin , Franko Uwe 
Published: April 2022

AbstractThe fertilization with organic amendments and digestates from biogas plants is increasingly used to increase carbon stock and to improve the soil quality, but little is still known about their long‐term effects. A common method to analyse organic amendments and their mineralization is incubation experiments, where amendments get incubated with soil while CO2 release is measured over time. In a previous study, carbon models have been applied to model the carbon dynamics of incubation experiments. The derived parameters describing the carbon turnover of the CCB model (CANDY Carbon Balance) are used to simulate the SOC and SON dynamics of a long‐term field trial. The trial was conducted in Berge (Germany) where organic amendments like slurry, farmyard manure or digestates were systematically applied. To grant a higher model flexibility, the amounts of crop residues were calculated for roots and stubble separately. Furthermore, the mineralization dynamics of roots and stubble are considered by the model parameters for each crop. The model performance is compared when using the dry matter and carbon content received from the field trial and the incubation experiments, to evaluate the transferability. The results show that the incubation parameters are transferable to the field site, with rRMSE < 10% for the modelled SOC and rRMSE between 10% and 15% for the SON dynamics. This approach can help to analyse long‐term effects of unexplored and unusual organic fertilizers under field conditions, whereat the model is used to upscale the C dynamics from incubation experiments, considering environmental conditions.
Detection of human herpesvirus 6 DNA and chromosomal integration after allogeneic hematopoietic stem cell transplantation: A retrospective single center analysis
Authors: Berneking Laura , Both Anna , Langebrake Claudia , Aepfelbacher Martin , Lütgehetmann Marc , Kröger Nicolaus , Christopeit Maximilian 
Published: April 2022

AbstractIntroductionHuman herpesvirus 6 (HHV‐6) can reactivate after allogeneic hematopoietic stem cell transplantation (allo‐HSCT) and may be associated with significant morbidity and mortality.MethodsThe epidemiology of HHV‐6 infections and their impact on outcome after allo‐HSCT were retrospectively analyzed in 689 adult allo‐HSCT recipients (January 2015–December 2018). Chromosomal integration of HHV‐6 (ciHHV‐6) in the donor was retrospectively investigated to critically evaluate antiviral treatment strategies.ResultsHHV‐6 DNA in any specimen was found in 89 patients. HHV‐6 infections (encephalitis (one), gastroenteritis (44), dermatitis (two), hepatitis (one), or pneumonitis (five)) were diagnosed in 53/689 patients (7.7%). Elevated levels of HHV‐6 DNA were found in 38 patients (5.5%). ciHHV‐6, analyzed in patients with HHV‐6 viral loads ≥104 copies/ml, was identified in four patients (10/38 patients; 10.5%). Two of those displayed copy numbers of HHV‐6 ranging from ≥2 × 105 to 2.5 × 106 copies/ml (HHV‐6A). Here, ciHHV‐6 was integrated into donor and not into the patients’ cells. In this series of allo‐HSCT recipients, 10.5% of patients with blood viral loads of HHV‐6 showed ciHHV‐6.ConclusionScreening of the donor for ciHHV‐6 before initiation of antiviral therapy is recommended.
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Sustainable Principles Implemented in Architecture and Interior Design through Eco Pieces of Furniture and Lighting
Authors: Munteanu Angela 
Published: April 2022

Objective: The research presents the efficiency of the studied topic, the theoretical and practical polices applied in ecological architecture and design, the importance and priorities of a healthy interior environment. The main statement that motivated this qualitative study is to explain clear principles of recycling and reuse through sustainability, supported by the high school curriculum.Methodology: The study focuses on developing awareness of critical thinking in society and academia, for recycling and reuse, - a process that leads to reducing environmental pollution, and waste emissions for the future of our descendants. The paper follows two directions for analysis. First of all, the ecology principles implemented by EU and fully supported by the Republic of Moldova through recent state directives and polices toward the sustainability. Secondly, the inclusion in the high school curriculum the projects concentraded on sustainability. Some examples of functional furniture, lighting and interior design pieces elaborated by students-architects and designers, promoting the possibility of recycling and reuse the waste materials, were presented.Findings: The analysis of the situation and the sustainable approach revealed three major postulates: First of all, the awareness of the attitude towards the environment and critical thinking of sustainability for future generationsб plausible messages both for the Moldovan society and for the academic environment. Finally, the implementation of critical awareness towards recycling and reuse of waste materials in the curriculum strategies for architects and interior designers led to development of future specialists in the field such as of sustainable products design.
Time‐limited alterations in cortical activity of a knock‐in mouse model of KCNQ2‐related developmental and epileptic encephalopathy
Authors: Biba‐Maazou Najoua , Becq Hélène , Pallesi‐Pocachard Emilie , Sarno Stefania , Granjeaud Samuel , Montheil Aurélie , Kurz Marie , Villard Laurent , Milh Mathieu , Santini Pierre‐Pascal Lenck , Aniksztejn Laurent 
Published: April 2022

AbstractDe novo missense variants in the KCNQ2 gene encoding the Kv7.2 subunit of voltage‐gated potassium Kv7/M channels are the main cause of developmental and epileptic encephalopathy with neonatal onset. Although seizures usually resolve during development, cognitive/motor deficits persist. To gain a better understanding of the cellular mechanisms underlying network dysfunction and their progression over time, we investigated in vivo, using local field potential recordings of freely moving animals, and ex vivo in layers II/III and V of motor cortical slices, using patch‐clamp recordings, the electrophysiological properties of pyramidal cells from a heterozygous knock‐in mouse model carrying the Kv7.2 p.T274M pathogenic variant during neonatal, postweaning and juvenile developmental stages. We found that knock‐in mice displayed spontaneous seizures preferentially at postweaning rather than at juvenile stages. At the cellular level, the variant led to a reduction in M ​​current density/conductance and to neuronal hyperexcitability. These alterations were observed during the neonatal period in pyramidal cells of layers II/III and during the postweaning stage in pyramidal cells of layer V. Moreover, there was an increase in the frequency of spontaneous network‐driven events mediated by GABA receptors, suggesting that the excitability of interneurons was also increased. However, all these alterations were no longer observed in layers II/III and V of juvenile mice. Thus, our data indicate that the action of the variant is regulated developmentally. This raises the possibility that the age‐related seizure remission observed in KCNQ2‐related developmental and epileptic encephalopathy patients results from a time‐limited alteration of Kv7 channel activity and neuronal excitability.Key points
The electrophysiological impact of the pathogenic c.821C>T mutation of the KCNQ2 gene (p.T274M variant in Kv7.2 subunit) related to developmental and epileptic encephalopathy has been analysed both in vivo and ex vivo in layers II/III and V of motor cortical slices from a knock‐in mouse model during development at neonatal, postweaning and juvenile stages.
M current density and conductance are decreased and the excitability of layer II/III pyramidal cells is increased in slices from neonatal and postweaning knock‐in mice but not from juvenile knock‐in mice.
M current and excitability of layer V pyramidal cells are impacted in knock‐in mice only at the postweaning stage.
Spontaneous GABAergic network‐driven events can be recorded until the postweaning stage, and their frequency is increased in layers II/III of the knock‐in mice.
Knock‐in mice display spontaneous seizures preferentially at postweaning rather than at juvenile stages.