bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visiting migrants: An introduction
Authors: Miah Md Farid , King Russell , Lulle Aija 
Published: December 2022

AbstractThis paper offers an overview of the origins and dynamics of the concept of migrant visits and introduces the key contributions of the special issue. We highlight the significance of visits that criss‐cross many forms of migration and centre on these visits’ bilateral and multilateral nature. Furthermore, we emphasize emotional, sensory and bodily implications, which almost always shape encounters between migrants and others in such visits. The papers of this special issue contribute to a broad interdisciplinary agenda highlighting familial ties, networks and transnational spaces at the core of migration and mobility scholarship. Together, we offer new perspectives on the multidirectionality of visits and the role of relationships which drive, connect and diversify forms of migration and are facilitated by broader developments in technology, tourism and diasporic practices.
Efficacy of minocycline hydrochloride aspiration sclerotherapy with additional monoethanolamine oleate aspiration sclerotherapy for symptomatic hepatic cysts
Authors: Kimura Yoshihide , Fujiwara Kei , Matsuura Kentaro , Suzuki Takanori , Senoo Kyouji , Tsuchida Kenji , Mori Yoshinori , Hirano Atsuyuki , Nomura Satoshi , Kitagawa Mika , Tomita Yusaku , Kanaiwa Hiroki , Imazu Mitsuki , Nagura Yoshihito , Nojiri Shunsuke , Kataoka Hiromi 
Published: December 2022

AbstractAimMinocycline hydrochloride (MINO) aspiration sclerotherapy (AS) has been widely used for treating hepatic cysts (HC). However, cyst recurrence remains problematic. Information on monoethanolamine oleate (EO) AS, another effective HC treatment, is currently limited. We investigated the efficacy of EO on ineffective MINO treatments, and the relationship between MINO AS and cyst fluid pH.MethodsA total of 22 cases with symptomatic HC underwent AS with 500 mg of MINO from January 2016 to June 2021. Cyst fluid pH was measured before and after MINO injection. Cyst volume ratio (CVR, %) after 2 weeks was calculated as follows:cyst volume 2 weeks after MINO injection / pre‐treatment cyst volume × 100. Treatment was completed if CVR after 2 weeks was ≤35% (MINO‐group). For patients with CVR >35%, 2 g of EO was added (MINO/EO‐group). Cyst volume ratio was measured every 12 months thereafter.ResultsThere were no recurrence symptoms in any of the patients during follow‐up. Of the 22 cases, 21 had CVR ≤20% after 12 months. The MINO/EO‐group (n = 8) tended to have smaller CVRs after 12 months than the MINO‐group (n = 14). Cyst volume ratio after 2 weeks was correlated to pH change (p = 0.012) and was larger in patients whose pH decreased by <1.5 (p = 0.015). All adverse events were mild, including in elderly patients.ConclusionAdding EO is an effective and safe treatment for symptomatic HC when MINO AS alone is insufficient. Patients with pH decreases of <1.5 should be considered for additional EO treatment.
Issue framing within the climate debate: An analysis of US environmental policy outcomes
Authors: Badruzzaman Aeshna , Kushi Sidita , Marion Summer 
Published: December 2022

AbstractThis paper argues different policy issue framings of climate change—ranging from security to energy, economics, humanitarian response, and health frames—play critical roles in altering policy outcomes. Specifically, we focus on the several windows of opportunity that altered the pathway of the US climate change debates from 1985 to 2017. Progressing from the underpinnings of issue framing literature and public policy discourse, we conduct content analysis of news articles, academic papers, policy documents and other archival evidence, to show why and when environmental framings shift, and to what effect. Our innovative models provide generalization of these trends and their implications for environmental agenda setting, complemented by a qualitative section that contextualizes impact as well as the feedback mechanisms of issue framing on environmental politics in the United States. The findings highlight the need for future case study analysis to trace the causal mechanisms between climate change framings and US policy outcomes.
Serum estradiol to testosterone ratio as a novel predictor of severe preeclampsia in the first trimester
Authors: Shen Yongmei , Cao Jiasong , Yao Liying , Li Shanshan , Zhao Xiaomin , Li Wen , Wei Zhuo , Zhang Lei , Wang Jianxi , Chang Ying 
Published: December 2022

AbstractPreeclampsia (PE) is the most common medical complication during pregnancy and the second leading cause of maternal death worldwide. However, a better predictive model of PE remains to be explored. A total of 15 severe preeclampsia (sPE) and 75 healthy control patients were included in this study. Patient data was obtained from September 2019 to September 2021. Nuchal translucency (NT) and crown‐rump length (CRL) of the fetus were acquired by ultrasound. Maternal blood samples were collected at 11+0 to 13+6 weeks of gestation. Chemiluminescent immunoassays were used to detect serum testosterone (T) and estradiol (E2) levels. Time‐resolved fluorescence analysis was used to examine the levels of serum pregnancy‐associated plasma protein A (PAPPA) and β‐human chorionic gonadotrophin (β‐HCG) protein. The sPE group exhibited increased T levels, and decreased E2 levels and E2/T ratios from 11 to 14 weeks of gestation, compared with the control group. E2 and the E2/T ratio showed positive linear correlation with CRL in pregnant women. Body‐mass‐index (BMI), T, and E2 were determined to be the main factors that affected the occurrence of sPE at the 12‐week gestation period time point. The receiver operating characteristic (ROC) curve revealed that the AUC of the E2/T ratio was .717. The imbalanced T and E2 levels in the patients had a specific intrinsic relevance with sPE, which suggests them as novel predictors of the sPE.
Circulating selenoprotein P levels predict glucose‐lowering and insulinotropic effects of metformin, but not alogliptin: A post‐hoc analysis
Authors: Takeshita Yumie , Tanaka Takeo , Takayama Hiroaki , Kita Yuki , Goto Hisanori , Nakano Yujiro , Saito Yoshiro , Takamura Toshinari 
Published: December 2022

AbstractAims/IntroductionSelenoprotein P (SeP; encoded by SEPP1 in humans) is a hepatokine that causes impaired insulin secretion and insulin resistance. Metformin downregulates SELENOP promoter activity through an adenosine monophosphate‐activated kinase–forkhead box protein O3a pathway in hepatocytes. This study aimed to test our hypothesis that circulating SeP levels are associated with the glucose‐lowering effect of metformin in humans.Materials and MethodsA total of 84 participants with poorly controlled type 2 diabetes were randomly assigned to receive metformin (1,000 mg, twice daily) or a dipeptidyl peptidase‐4 inhibitor, alogliptin (25 mg, once daily) for 12 weeks. We tested metformin and alogliptin on SeP levels and factors associated therewith as a post‐hoc analysis.ResultsBoth metformin and aloglipitin did not change the SeP levels. Although metformin significantly increased the insulin secretory index secretory units of islets in transplantation only in participants with higher baseline SeP (>3.87), both agents similarly reduced fasting plasma glucose and glycated hemoglobin. SeP levels at baseline were correlated negatively with changes in SeP (r = −0.484, P = 0.004) and fasting plasma glucose (r = −0.433, P = 0.011), and positively with changes in C‐peptide immunoreactivity (r = 0.420, P = 0.017) and secretory units of islets in transplantation (r = 0.388, P = 0.028) in the metformin, but not alogliptin, group.ConclusionsHigher baseline levels of SeP significantly predicted metformin‐mediated, but not alogliptin‐mediated, glucose‐lowering and insulinotropic effects. Serum SeP levels might be a novel biomarker for predicting the outcomes of metformin therapy, which might be helpful in tailoring diabetes medication.
Health insurance coverage during the COVID‐19 pandemic: The role of Medicaid expansion
Authors: Mandal Bidisha , Porto Nilton , Kiss D. Elizabeth , Cho Soo Hyun , Head Lorna Saboe‐Wounded 
Published: December 2022

AbstractUsing data from the US Census Bureau's Household Pulse Survey, we analyzed the likelihood of loss of health insurance and enrollment into new health coverage during the early months of the COVID‐19 pandemic. Loss of employment was associated with a significant increase in the likelihood of loss of health insurance and, specifically, an increase in the likelihood of employer‐sponsored health insurance. However, individuals in Medicaid expansion states experienced a lower likelihood of loss of health insurance compared with individuals in nonexpansion states. At the same time, there was a statistically significant increase in Medicaid enrollment in expansion states, by 3.2 percentage points. Reemployment or acquiring employment was associated with a gain in health insurance coverage. During an economic downturn, eligibility, and coverage gaps leave many without affordable coverage options, and the pandemic will likely bring renewed attention to gaps in Medicaid coverage in nonexpansion states.
A brief assessment of eye blink drowsiness immediately prior to or following driving detects drowsiness related driving impairment
Authors: Cori Jennifer M. , Wilkinson Vanessa E. , Soleimanloo Shamsi Shekari , Westlake Justine , Stevens Bronwyn , Rajaratnam Shantha M. W. , Howard Mark E. 
Published: December 2022

SummaryDrowsy driving is a major cause of fatal and serious injury motor vehicle accidents. The inability objectively to assess drowsiness has hindered the assessment of fitness to drive and the development of drowsy driving regulations. This study evaluated whether spontaneous eye blink parameters measured briefly pre‐ and post‐drive could be used to detect drowsy driving impairment. Twelve healthy participants (6 female) drove an instrumented vehicle for 2 h on a closed‐loop track during a rested (8–10 h awake) and an extended wake condition (32–34 h awake). Pre‐ and post‐drive, the participants completed a 5 min eye blink task, a psychomotor vigilance task (PVT), and the Karolinska sleepiness scale (KSS). Whole drive impairment was defined as >3.5 lane departures per hour. Severe end of drive impairment was defined as ≥2 lane departures in the last 15 min. The pre‐drive % of time with eyes closed best predicted the whole drive impairment (area under the curve [AUC] 0.87). KSS had similar prediction ability (AUC 0.85), while PVT reaction time (AUC 0.72) was less accurate. The composite eye blink parameter, the Johns drowsiness scale was the best retrospective detector of severe end of drive impairment (AUC 0.99). The PVT reaction time (AUC 0.92) and the KSS (AUC 0.93) were less accurate. Eye blink parameters detected drowsy driving impairment with an accuracy that was similar to, or marginally better than, PVT and KSS. As eye blink measures are simple to measure, are objective and have high accuracy, they present an ideal option for the assessment of fitness for duty and roadside drowsiness.
Silent HDV epidemics culminates in high levels of liver cirrhosis in endemic region despite 20 years of HBV vaccination
Authors: Isaeva Olga V. , Kyuregyan Karen K. , Karlsen Anastasia A. , Kuzmin Oleg V. , Potemkin Ilya A. , Kichatova Vera S. , Asadi Mobarkhan Fedor A. , Mullin Eugeniy V. , Kozhanova Tatyana V. , Manuylov Victor A. , Pochtovyy Andrey A. , Gushchin Vladimir A. , Saryglar Anna A. , Ilchenko Lyudmila Yu. , Mikhailov Mikhail I. 
Published: December 2022

AbstractThe hepatitis delta virus (HDV) is believed to be a vanishing infection in countries with successful hepatitis B virus (HBV) vaccination programs. We assessed the current status of HDV infection in Tuva, a region of the Russia that has been highly endemic for HBV. The proportion of HDV‐infected patients among HBsAg‐positive patients in the regional registry in 2020 was 32.7% (786/2401). An analysis of the medical records of 514 HDV patients demonstrated that 37.5% (193/514) had liver cirrhosis at the first doctor's visit, and 7.4% of patients lived in families where another family member had HDV. All HDV patients were infected with genotype HDV‐1, 94.5% had HBV genotype D, and 5.5% had genotype A. A serosurvey conducted among 1170 healthy volunteers showed that the average detection rate of HBsAg with anti‐HDV was 1.0% (95% CI: 0.57–1.81%). No anti‐HDV positive samples were detected in participants aged under 30 years. The HBsAg/anti‐HDV positivity rate peaked at 7.4% in patients aged 50–59 years, which was significantly higher than in a similar age cohort surveyed in 2008 (1.6%, p < .0001). A Bayesian analysis showed that HDV circulation in Tuva resulted from two waves of introduction, the first in the 1810s (95% HPD: 1741–1834) from Central Asia, and the second in the 1960s (95% HPD: 1953–1979) from Russia. HBV has a much longer history of circulation in Tuva with the MRCA for the predominant genotype HBV‐D dated to 972 (95% HPD: 535–1253) for subtype D1, 1274 (95% HPD: 936–1384) for D2, and 1173 (95% HPD: 1005–1618) for D3. A SkyGrid reconstruction of population dynamics showed an increase in the intensity of HDV spread in recent decades. This situation shows the need for HDV screening and prevention measures among people living with HBV.
Differences in medication adherence by sex and organ type among adolescent and young adult solid organ transplant recipients
Authors: Vaisbourd Yulia , Dahhou Mourad , Zhang Xun , Sapir‐Pichhadze Ruth , Cardinal Heloise , Johnston Olwyn , Blydt‐Hansen Tom D. , Tibbles Lee Anne , Hamiwka Lorraine , Urschel Simon , Birk Patricia , Bissonnette Janice , Matsuda‐Abedini Mina , BScPhm Jennifer Harrison , Schiff Jeffrey , Phan Veronique , De Geest Sabina , Allen Upton , Avitzur Yaron , Mital Seema , Foster Bethany J. 
Published: December 2022

AbstractBackgroundIdentification of differences in medication adherence by sex or organ type may help in planning interventions to optimize outcomes. We compared immunosuppressive medication adherence between males and females, and between kidney, liver and heart transplant recipients.MethodsThis multicenter study of prevalent kidney, liver and heart transplant recipients 14–25 years assessed adherence 3 times (0, 3, 6 months post‐enrollment) with the BAASIS self‐report tool. At each visit, participants were classified as adherent if they missed no doses in the prior 4 weeks and non‐adherent otherwise. Adherence was also assessed using the coefficient of variation (CV) of tacrolimus trough levels; CV < 30% was classified as adherent. We used multivariable mixed effects logistic regression models adjusted for potential confounders to compare adherence by sex and by organ.ResultsAcross all visits, males (n = 150, median age 20.4 years, IQR 17.2–23.3) had lower odds of self‐reported adherence than females (n = 120, median age 19.8 years, IQR 17.1–22.7) (OR 0.41, 95% CI 0.21–0.80) but higher odds of adherence by tacrolimus CV (OR 2.50, 95% CI 1.30–4.82). No significant differences in adherence (by self‐report or tacrolimus CV) were noted between the 184 kidney, 58 liver, and 28 heart recipients.ConclusionFemales show better self‐reported adherence than males but greater variability in tacrolimus levels. Social desirability bias, more common in females than males, may contribute to better self‐reported adherence among females. Higher tacrolimus variability among females may reflect biologic differences in tacrolimus metabolism between males and females rather than sex differences in adherence. There were no significant differences in adherence by organ type.
Factors affecting time to treatment initiation after diagnosis for multidrug‐resistant/rifampicin‐resistant tuberculosis patients: A mixed‐methods study in Jakarta, Indonesia
Authors: Silitonga Permata , Jiang Weixi , Wyatt Sage , Burhan Erlina , Kes Esty Febriani M. , Long Qian 
Published: December 2022

AbstractObjectiveTo investigate the time to treatment initiation (TTI) for multidrug‐resistant/rifampicin‐resistant tuberculosis (MDR/RR‐TB) patients after diagnosis in Indonesia and biological, psychological and social factors associated with the time interval.MethodsThis study was conducted in Persahabatan Hospital, Jakarta using a mixed‐methods approach. Registry data and medical records of MDR/RR‐TB patients were collected and matched (hospital dataset), and linked with psychosocial assessment results (linked dataset). Descriptive analysis was conducted to understand patient characteristics and the distribution of TTI after RR‐TB diagnosis by GeneXpert. Generalised linear regression was used to analyse factors associated with delay duration, and logistic regression to explore factors associated with the delay longer than the median duration for both datasets (basic vs. extended model). In‐depth interviews were conducted with patients and healthcare workers to understand the procedure of treatment initiation and how different factors led to delay.ResultsThe hospital dataset included 275 patient‐matched cases, and 188 were further linked with psychosocial assessment results. The median time interval was 24 days [interquartile range (IQR) 23.5] and 26 days (IQR 21.25), respectively. Regression analysis showed that in the extended model, comorbidities (exp [coefficient]= 1.93), unemployment (exp [coefficient] = 1.80) and poor knowledge of MDR/RR‐TB (exp (coefficient) = 1.67) seemed to have the strongest effects on prolonging the time interval (p < 0.05). Unsuccessful TB treatment history was the only factor that significantly increased the risk of delay longer than the median duration (p < 0.05) in the basic model, while none of the factors were significant in the extended model. The qualitative study identified provider‐side factors (centralised service provision and insufficient human resources) and patient‐side factors (physical weakness, psychological stress and financial concern) associated with treatment delay.ConclusionMDR/RR‐TB patients in Persahabatan Hospital, Jakarta, Indonesia waited around 25 days for treatment initiation after RR‐TB diagnosis. Health system solutions are needed to address challenges facing both MDR/RR‐TB patients and healthcare providers to reduce delay in treatment initiation.
Platelet function of whole blood after short‐term cold storage: A prospective in vitro observational study
Authors: Kusudo Eriko , Murata Yutaka , Matsumoto Tsuguhiro , Kawamoto Shuji , Egi Moritoki 
Published: December 2022

AbstractBackgroundThere is no standardized storage temperature of whole blood for acute normovolemic hemodilution (ANH).Study Design and MethodsWe conducted a prospective observational study to examine the difference in platelet function between short‐term whole blood storage at 4 and 22°C. Venous blood (40 ml) was collected from seven healthy subjects who gave prior written consent. The samples were divided into three groups: before storage (group Pre), cold (4°C) storage (group C), and room temperature (22°C) storage (group R). Groups C and R were tested after 6 h of blood storage. Platelet aggregability, platelet factor 4 (PF4), β‐thromboglobulin (β‐TG), P‐selectin expression, pH, PO2, PCO2, glucose, lactate, blood count, and thromboelastography (TEG) parameters were measured. The percentage change in each parameter in groups C and R was calculated using the value in group Pre as a reference. These data were then compared between groups C and R using a Wilcoxon matched pairs test. p < 0.05 was considered to be statistically significant.ResultsCompared with group R, group C showed significantly higher platelet aggregability with adenosine diphosphate (ADP) 2, 4, and 6 μM (all p = 0.016) and collagen 1 μg/ml (p = 0.047) stimulation, and significantly lower PF4 and β‐TG elevation (both p = 0.031), glucose consumption (p = 0.031), and lactate production (p = 0.016). The ADP channel in TEG showed a significant increase in platelet aggregation rate in group C compared to group R.DiscussionCold storage of whole blood in ANH may provide improved storage conditions for platelets and contribute to improved hemostasis compared to room temperature storage.
Microwave Ablation Trocar Operated at Dual Tine Dual-Frequency: A Numerical Analysis
Authors: Satish Vellavalapalli , Repaka Ramjee 
Published: December 2022

AbstractMicrowave ablation (MWA) is a minimally invasive thermal ablation technique that has the advantages of obtaining high intratumoral temperatures, less treatment time, and large ablation region as compared to other thermal ablation techniques. The ablation region obtained during MWA procedure mainly depends on the design and type of the trocar being used. The trocar plays an essential role in the MWA system by governing the energy distribution during tissue ablation. In this study, a novel MWA trocar design has been considered to achieve concentrated ablation region along the tumor’s spatial distribution. A dual tine trocar with each tine supplied with energy at different frequencies (2.45 GHz and 6 GHz) has been considered for tumor ablation. Commercially available Finite Element based software has been used (comsol-multiphysics) to analyze the extent of ablation zone. Coupled bioheat and electromagnetic physics interfaces have been utilized. Results showed that the proposed trocar with tines operating at 6 GHz on both the tines leads to a large ablation region (3 cm in diameter) with spherical in shape. Irregularly shaped ablation region can also be achieved by this trocar with tines operating at different frequencies. The minimum time required for complete tumor ablation by the trocar operated at 6 GHz is 4 min, followed by 6 min for the trocar operated at 2.45 GHz. The proposed trocar can become a part of a better treatment planning system based on tumor shape, nearby blood vessel presence, and the trocar's precise insertion.
Transient Thermomechanical Stress Analysis of Hot Surface Ignition Device Using Sequentially Coupled Computational Fluid Dynamics–Finite Element Analysis Approach
Authors: Kang Sang-Guk , Ryu Je Ir , Motily Austen H. , Numkiatsakul Prapassorn , Lee Tonghun , Kriven Waltraud M. , Kim Kenneth S. , Kweon Chol-Bum M. 
Published: December 2022

Abstract
Energy addition using a hot surface ignition device is required for reliable ignition of aircraft compression ignition engines running on fuel variations and at altitude conditions. Thus, durability of the hot surface ignition device is crucial for application in these engines. Thermomechanical stress is one of the key parameters that determine durability, which requires an accurate prediction of the transient temperature field based on well-defined boundary conditions representing the dynamic and complex fluid flow inside engines. To meet this requirement, the present study focuses on transient thermomechanical stress analysis using a sequentially coupled computational fluid dynamics (CFD)–finite element analysis (FEA) approach to understand transient thermomechanical responses of the hot surface ignition device. A three-dimensional transient reacting flow simulation was conducted first using converge software, the results of which were exported to map thermal and pressure boundary conditions onto a structural finite element mesh. Transient thermomechanical stress analysis was performed sequentially using abaqus software utilizing the mapped boundary conditions. The results such as transient temperature history, resultant thermomechanical stress, displacement, potential failure modes, etc., were critically reviewed, which can provide helpful information for further design improvement.