bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promoting Cardiac Repair through Simple Engineering of Nanoparticles with Exclusive Targeting Capability toward Myocardial Reperfusion Injury by Thermal Resistant Microfluidic Platform
Authors: Liu Zehua , Lian Wenhua , Long Qiang , Cheng Ruoyu , Torrieri Giulia , Zhang Baoding , Koivuniemi Artturi , Mahmoudzadeh Mohammad , Bunker Alex , Gao Han , He Hongbin , Chen Yun , Hirvonen Jouni , Zhou Rongbin , Zhao Qiang , Ye Xiaofeng , Deng Xianming , Santos Hélder A. 
Published: June 2022

AbstractNanoparticle (NP)‐based intravenous administration represents the most convenient cardiac targeting delivery routine, yet, there are still therapeutic issues due to the lack of targeting efficiency and specificity. Active targeting methods using functionalization of ligands onto the NPs’ surface may be limited by trivial modification procedures and reduced targeting yield in vivo. Here, a microfluidics assisted single step, green synthesis method is introduced for producing targeting ligands free heart homing NPs in a tailored manner. The generated β‐glucan‐based NPs exhibit precise and efficient targeting capability toward Dectin‐1+ monocytes/macrophages, which are confirmed as main pathogenesis mediators for cardiac ischemic/reperfusion (I/R) injury, with a sequentially enhanced cardiac NP accumulation, and this targeting strategy is exclusively suitable for cardiac I/R but not for other cardiovascular diseases, as confirmed both in murine and human model. Comparing to FDA‐approved nano‐micelles formulation, β‐glucan NPs loaded with NACHT, LRR, and PYD domains‐containing protein 3 (NLRP3) inflammasome inhibitor (CY‐09) exhibit better efficiency in ameliorating myocardial injury and heart failure induced by surgically induced I/R. These findings indicate a simple production of targeting‐ligand free NPs, and demonstrate their potential therapeutic applications for preclinical I/R‐induced cardiac injury amelioration.
Instantaneous High‐Resolution Visual Imaging of Latent Fingerprints in Water Using Color‐Tunable AIE Pincer Complexes
Authors: Duan Lixin , Zheng Qingshu , Tu Tao 
Published: June 2022

AbstractInstant visualization of latent fingerprints is developed by using a series of water‐soluble terpyridine zinc complexes as aggregation‐induced emission probes in pure water, under UV light or ambient sunlight. By simply soaking, or spraying with an aqueous solution of the probe, bright yellow fluorescence images with high contrast and resolution are readily developed on various surfaces including tinfoil, glass, paper, steel, leather, and ceramic tile. Remarkably, latent fingerprints can be visualized within seconds including details of whorl and sweat pores. The color of emission can be tuned from blue to orange by modifying the pincer ligands, allowing direct imaging under sunlight. These inexpensive, water‐resistant, and color‐tunable probes provide a practical approach for latent fingerprints recording and analysis, security protection, as well as criminal investigation in different scenarios.
Noncovalent Polymerization‐Activated Ultrastrong Near‐Infrared Room‐Temperature Phosphorescence Energy Transfer Assembly in Aqueous Solution
Authors: Dai Xian‐Yin , Huo Man , Dong Xiaoyun , Hu Yu‐Yang , Liu Yu 
Published: June 2022

AbstractNoncovalent macrocycle‐confined supramolecular purely organic room‐temperature phosphorescence (RTP) is a current research hotspot. Herein, a high‐efficiency noncovalent polymerization‐activated near‐infrared (NIR)‐emissive RTP‐harvesting system in aqueous solution based on the stepwise confinement of cucurbit[7]uril (CB[7]) and β‐cyclodextrin‐grafted hyaluronic acid (HACD), is reported. Compared with the dodecyl‐chain‐bridged 6‐bromoisoquinoline derivative (G), the dumbbell‐shaped assembly G⊂CB[7] presents an appeared complexation‐induced RTP signal at 540 nm via the first confinement of CB[7]. Subsequently, benefitting from the stepwise confinement encapsulation of the β‐cyclodextrin cavity, the subsequent noncovalent polymerization of the binary G⊂CB[7] assembly enabled by HACD can contribute to the further‐enhanced RTP emission intensity approximately eight times in addition to an increased lifetime from 59.0 µs to 0.581 ms. Moreover, upon doping a small amount of two types of organic dyes, Nile blue or tetrakis(4‐sulfophenyl)porphyrin as an acceptor into the supramolecular confinement assembly G⊂CB[7] @ HACD, efficient RTP energy transfer occurs accompanied by a long‐lived NIR‐emitting performance (680 and 710 nm) with a high donor/acceptor ratio. Intriguingly, the prepared RTP‐harvesting system is successfully applied for targeted NIR imaging of living tumor cells by utilizing the targeting ability of hyaluronic acid, which provides a new strategy to create advanced water‐soluble NIR phosphorescent materials.
Enhancement of Near‐Infrared Phosphor Luminescence Properties via Construction of Stable and Compact Energy Transfer Paths
Authors: Wei Guohui , Wang Zhijun , Li Rui , Wang Ye , Li Jiehong , Shi Yawei , He Shaoxuan , Yang Yuanbo , Yang Zhiping , Li Panlai 
Published: June 2022

AbstractThe rapid development of near‐infrared (NIR) spectroscopy urgently requires the exploration of NIR‐emitting phosphors with excellent luminescence properties. Herein, GaTaO4:Cr3+,Yb3+ NIR phosphor with excellent luminescence properties is reported, which exhibits ultra‐broadband NIR emission with a full width at half maximum of 300 nm, good thermal stability of 90%@423 K, and most remarkably, high internal quantum efficiency of 95.5% and external quantum efficiency of 44.79%. Such outstanding luminescence properties mainly give the credit to the unique sandwiched structure of GaTaO4:Cr3+,Yb3+, in which layers of Yb3+ ions (activator) are sandwiched between layers of Cr3+ ions (sensitizer), and hence many stable and compact Cr–Yb pairs are formed, so that the energy can be rapidly transferred from Cr3+ to Yb3+, effectively activating the characteristic f–f transition of Yb3+ that is very stable and almost independent of the temperature, and at the same time, the non‐radiative transition of Cr3+ ions can be suppressed to a certain degree. The NIR phosphor‐converted light‐emitting diodes (pc‐LEDs) are fabricated by combining GaTaO4:Cr3+,Yb3+ with blue LED chips, and the application potential is fully demonstrated by non‐destructive food detection, night vision, and vein display. The results provide novel prospects for the design of NIR‐emitting materials with desirable luminescent properties.
Machine Learning Modeling for Accelerated Battery Materials Design in the Small Data Regime
Authors: Sendek Austin D. , Ransom Brandi , Cubuk Ekin D. , Pellouchoud Lenson A. , Nanda Jagjit , Reed Evan J. 
Published: June 2022

AbstractMachine learning (ML)‐based approaches to battery design are relatively new but demonstrate significant promise for accelerating the timeline for new materials discovery, process optimization, and cell lifetime prediction. Battery modeling represents an interesting and unconventional application area for ML, as datasets are often small but some degree of physical understanding of the underlying processes may exist. This review article provides discussion and analysis of several important and increasingly common questions: how ML‐based battery modeling works, how much data are required, how to judge model performance, and recommendations for building models in the small data regime. This article begins with an introduction to ML in general, highlighting several important concepts for small data applications. Previous ionic conductivity modeling efforts are discussed in depth as a case study to illustrate these modeling concepts. Finally, an overview of modeling efforts in major areas of battery design is provided and several areas for promising future efforts are identified, within the context of typical small data constraints.
Powering the World with Solar Fuels from Photoelectrochemical CO2 Reduction: Basic Principles and Recent Advances
Authors: Li Deng , Yang Kaixin , Lian Juhong , Yan Junqing , Liu Shengzhong (Frank) 
Published: June 2022

AbstractCarbon neutrality has become an urgent mission for the future of mankind. Powering the world with renewable energy from solar CO2 reduction represents a promising way to accomplish this target. Photoelectrochemical (PEC) CO2 reduction, integrating the merits of photocatalysis and electrocatalysis, offers an intriguing and effective approach to realizing solar fuel production and CO2 mitigation in one shot. To stimulate research efforts in PEC CO2 reduction, a comprehensive review of recent advances in this field is presented, with a special emphasis on the general design motives for the assembly of highly efficient PEC cells. First, basic principles and evaluating parameters of PEC CO2 reduction cells are introduced. Then, recent innovative PEC cells with highly active photocathodes for CO2 reduction to different target chemicals are highlighted and the material designing principles are discussed. In addition, the representative self‐biased PEC CO2 reduction cells including the tandem and artificial‐leaf configurations are also addressed. Finally, this review is concluded with remarks on the present achievements in PEC CO2 reduction to different chemicals, pointing out some effective strategies to promote the efficiencies for solar fuel production. A vision of the challenges and opportunities for how to forward PEC CO2 reduction research is further provided.
Systematic study on fabrication of hollow poly(vinyl cinnamate) particles by particulate interfacial photocrosslinking
Authors: Kitayama Yukiya , Harada Atsushi 
Published: June 2022

AbstractHollow polymer particles are widely used in various industries as coatings and thermal insulation materials. The encapsulation capabilities of various functional molecules and/or nanomaterials also provide access to applications such as drug delivery, heat storage, and catalysis, as well as self‐healing materials. In this study, we successfully fabricated hollow polymer particles from poly(vinyl cinnamate) (PVC) particles using LED light (λ = 265 nm) through interfacial photocrosslinking. Furthermore, we systematically studied the effect of various parameters (solid contents of parent particles, photoirradiation time, photoirradiation power, and polymer chain length) on the polymer shell thickness of the hollow PVC particles fabricated by interfacial photocrosslinking. These findings are expected to further promote the use of hollow polymer particles in pharmaceutical and material applications.
Traumatic brain injury and post‐traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers
Authors: Weiner Michael W. , Harvey Danielle , Landau Susan M , Veitch Dallas P. , Neylan Thomas C. , Grafman Jordan H. , Aisen Paul S. , Petersen Ronald C. , Jack Jr Clifford R. , Tosun Duygu , Shaw Leslie M. , Trojanowski John Q. , Saykin Andrew J. , Hayes Jacqueline , De Carli Charles ,   for the Alzheimer's Disease Neuroimaging Initiative and the Department of Defense Alzheimer's Disease Neuroimaging Initiative
Published: June 2022

AbstractIntroductionEpidemiological studies report an association between traumatic brain injury (TBI) and post‐traumatic stress disorder (PTSD) and clinically diagnosed Alzheimer's disease (AD). We examined the association between TBI/PTSD and biomarker‐defined AD.MethodsWe identified 289 non‐demented veterans with TBI and/or PTSD and controls who underwent clinical evaluation, cerebrospinal fluid (CSF) collection, magnetic resonance imaging (MRI), amyloid beta (Aβ) and tau positron emission tomography, and apolipoprotein E testing. Participants were followed for up to 5.2 years.ResultsExposure groups (TBI, PTSD, and TBI + PTSD) had higher prevalence of mild cognitive impairment (MCI: P < .0001) and worse Mini‐Mental State Examination scores (PTSD: P = .008; TBI & PTSD: P = .009) than controls. There were no significant differences in other cognitive scores, MRI volumes, Aβ or tau accumulation, or in most longitudinal measures.DiscussionTBI and/or PTSD were not associated with elevated AD biomarkers. The poorer cognitive status of exposed veterans may be due to other comorbid pathologies.
In Situ Real‐Time Nanoscale Resolution of Structural Evolution and Dynamics of Fluorescent Self‐Assemblies by Super‐Resolution Imaging
Authors: Qiao Qinglong , Liu Wenjuan , Zhang Yinchan , Chen Jie , Wang Guangying , Tao Yi , Miao Lu , Jiang Wenchao , An Kai , Xu Zhaochao 
Published: June 2022

AbstractThe visualization of self‐assembled structure and dynamics at the molecular level has become a powerful method to understand structure–function relationships of self‐assembly. Herein, we in situ real‐time imaged the dynamic process of benzyl‐naphthalimide dyes at the nanoscale and inspected their internal structure with minimum 2.8 nm localization accuracy through single‐molecule localization microscopy (SMLM) imaging. We monitored the growth process of three different assemblies in situ, which possessed highly heterogeneous dynamics with different shapes and growth rates. Furthermore, diverse growth rates were also found at different sites in the same assembly. These results highlight the application of super‐resolution microscopy techniques for real‐time visualization of internal assembled structure and dynamics in situ.
Efficient Synthesis of C3‐Alkylated and Alkenylated Indoles via Manganese‐Catalyzed Dehydrogenation
Authors: Zhao Mingqin , Li Xinyan , Zhang Xiaoyu , Shao Zhihui 
Published: June 2022

AbstractThe catalytic dehydrogenation of alcohols is essential for the sustainable production of valuable products. This provides a new strategy for green organic synthesis in chemical industries. Herein, we describe a manganese‐based catalytic system that enables the efficient synthesis of C3‐alkylated indoles from benzyl alcohols and indoles via the borrowing hydrogen process. Furthermore, dehydrogenative coupling of 2‐arylethanols and indoles yields C3‐alkenylated indoles. Meanwhile, reacting 2‐aminophenethanol instead of indoles can also obtain the corresponding indole products with high selectivity under the same conditions.
Synthesis of homogeneous and bright deep blue CsPbBr3 perovskite nanoplatelets with solidified surface for optoelectronic material
Authors: Kim Taeyun , Suh Yo‐Han , Kim Kangyong , Kim Hyeonjung , Park Jongnam 
Published: June 2022

AbstractHalide perovskite nanocrystals have easily tunable emissions throughout the visible spectrum, making them an extremely promising material for light‐emitting applications. Whereas high quantum yield and long‐term colloidal stability have already been achieved for nanocrystals emitting in the red and green spectral range, the blue region currently lags behind with low quantum yields and insufficient colloidal stability. In this study, we present a facile synthetic and postsynthetic approach for obtaining two‐dimensional CsPbBr3 nanoplatelets (NPLs) with homogeneous‐thickness control of their solidified surface, resulting in sharp photoluminescence and electroluminescence peaks with a deep‐blue emission at 465‐nm wavelength owing to quantum confinement. The subsequent addition of a solidifying ligand solution seals the surface defects likely stemming from vacancies within a subensemble of weakly emissive NPLs. The overall photoluminescence quantum yield of the blue‐emissive colloidal dispersions is consequently enhanced by 65% ± 2%.
Kartogenin (KGN)/synthetic melanin nanoparticles (SMNP) loaded theranostic hydrogel scaffold system for multiparametric magnetic resonance imaging guided cartilage regeneration
Authors: Chen Chuyao , Huang Shaoshan , Chen Zelong , Liu Qin , Cai Yu , Mei Yingjie , Xu Yikai , Guo Rui , Yan Chenggong 
Published: June 2022

AbstractCartilage regeneration after injury is still a great challenge in clinics, which suffers from its avascularity and poor proliferative ability. Herein we designed a novel biocompatible cellulose nanocrystal/GelMA (gelatin‐methacrylate anhydride)/HAMA (hyaluronic acid‐methacrylate anhydride)‐blended hydrogel scaffold system, loaded with synthetic melanin nanoparticles (SMNP) and a bioactive drug kartogenin (KGN) for theranostic purpose. We found that the SMNP‐KGN/Gel showed favorable mechanical property, thermal stability, and distinct magnetic resonance imaging (MRI) contrast enhancement. Meanwhile, the sustained release of KGN could recruit bone‐derived mesenchymal stem cells to proliferate and differentiate into chondrocytes, which promoted cartilage regeneration in vitro and in vivo. The hydrogel degradation and cartilage restoration were simultaneously monitored by multiparametric MRI for 12 weeks, and further confirmed by histological analysis. Together, these results validated the multifunctional hydrogel as a promising tissue engineering platform for noninvasive imaging‐guided precision therapy in cartilage regenerative medicine.
Direct administration of mesenchymal stem cell‐derived mitochondria improves cardiac function after infarction via ameliorating endothelial senescence
Authors: Liang Xiaoting , Zhang Yuelin , Lin Fang , Li Mimi , Li Xin , Chen Yu , Liu Jing , Meng Qingshu , Ma Xiaoxue , Wang Enhao , Wei Lu , He Zhiying , Fan Huimin , Zhou Xiaohui , Ding Yue , Liu Zhongmin 
Published: June 2022

AbstractMitochondrial dysfunction is considered to be a key contributor to the development of heart failure. Replacing injured mitochondria with healthy mitochondria to restore mitochondrial bioenergy in myocardium holds great promise for cardioprotection after infarction. This study aimed to investigate whether direct transplantation of exogenous mitochondria derived from mesenchymal stem cells (MSC‐mt) is beneficial and superior in protecting cardiac function in a mouse model of myocardial infarction (MI) compared to mitochondria derived from skin fibroblast (FB‐mt) and to explore the underlying mechanisms from their effects on the endothelial cells. The isolated MSC‐mt presented intact mitochondrial morphology and activity, as determined by electron microscopy, JC‐1 mitochondrial membrane potential assay, and seahorse assay. Direct injection of MSC‐mt into the peri‐infarct region in a mouse MI model enhanced blood vessel density, inhibited cardiac remodeling and apoptosis, thus improving heart function compared with FB‐mt group. The injected MSC‐mt can be tracked in the endothelial cells. In vitro, the fluorescence signal of MSC‐mt can be detected in human umbilical vein endothelial cells (HUVECs) by confocal microscopy and flow cytometry after coculture. Compared to FB‐mt, MSC‐mt more effectively protected the HUVECs from oxidative stress‐induced apoptosis and reduced mitochondrial production of reactive oxygen species. MSC‐mt presented superior capacity in inducing tube formation, enhancing SCF secretion, ATP content and cell proliferation in HUVECs compared to FB‐mt. Mechanistically, MSC‐mt administration alleviated oxidative stress‐induced endothelial senescence via activation of ERK pathway. These findings suggest that using MSCs as sources of mitochondria is feasible and that proangiogenesis could be the mechanism by which MSC‐mt transplantation attenuates MI. MSC‐mt transplantation might serve as a new therapeutic strategy for treating MI.
Cold air plasma improving rheumatoid arthritis via mitochondrial apoptosis pathway
Authors: Ding Chengbiao , Ni Leying , Liu Qi , Zhou Chenxu , Wang Guomin , Chu Paul K. , Wu Zhengwei 
Published: June 2022

AbstractRheumatoid arthritis (RA) has plagued physicians and patients for years due to the lack of targeted treatment. In this study, inspired by the commonality between rheumatoid arthritis fibroblast‐like synoviocytes (RA‐FLS) and cancer cells, the therapeutic effects of cold air plasma (CAP) on RA are studied systematically and thoroughly. In/ex vivo results show that CAP with the proper dosage significantly relieves symptoms including synovial hyperplasia, inflammatory infiltration, and angiogenesis and eliminates the root cause by triggering the self‐antioxidant capability of the surrounding tissue. The mechanism on the molecular and cellular level is also revealed that the spontaneous reactive oxygen species (ROS) cascade induces the mitochondrial apoptosis pathway on RA‐FLS. This study reveals a new strategy for targeted treatment of RA and the mechanistic study provides the theoretical foundation for future development of plasma medicine.
The impact of temozolomide and lonafarnib on the stemness marker expression of glioblastoma cells in multicellular spheroids
Authors: Nakod Pinaki S. , Kondapaneni Raghu Vamsi , Edney Brandon , Kim Yonghyun , Rao Shreyas S. 
Published: June 2022

AbstractGlioblastoma multiforme (GBM) is a highly malignant brain tumor with a poor prognosis. The GBM microenvironment is highly heterogeneous and is composed of many cell types including astrocytes and endothelial cells (ECs) along with tumor cells, which are responsible for heightened resistance to standard chemotherapeutic drugs such as Temozolomide (TMZ). Here, we investigated how drug treatments impact stemness marker expression of GBM cells in multicellular tumor spheroid (MCTS) models. Co‐ and tri‐culture MCTS constructed using U87‐MG GBM cells, astrocytes, and/or ECs were cultured for 7 days. At Day 7, 5 μM lonafarnib (LNF), 100 μM TMZ, or combination of 5 μM LNF + 100 μM TMZ was added and the MCTS were cultured for an additional 48 h. We assessed the spheroid sizes and expression of stemness markers‐ NESTIN, SOX2, CD133, NANOG, and OCT4‐ through qRT‐PCR and immunostaining. Following 48 h treatment with LNF, TMZ or their combination (LNF + TMZ), the spheroid sizes decreased compared to the untreated control. We also observed that the expression of most of the stemness markers significantly increased in the LNF + TMZ treated condition as compared to the untreated condition. These results indicate that drug treatment can influence the stemness marker expression of GBM cells in MCTS models and these aspects must be considered while evaluating therapies. In future, by incorporating other relevant cell types, we can further our understanding of their crosstalk, eventually leading to the development of new therapeutic strategies.