bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influenza vaccination features revealed by a single‐cell transcriptome atlas
Authors: Wang Yi , Wang Xiaoxia , Jia Xinbei , Li Jieqiong , Fu Jin , Huang Xiaolan , Cui Xiaodai , Wang Bike , Luo Wenkai , Lin Chengcong , Li Zhenjun , Luu Laurence Don Wai , Li Shijun , Zhu Xiong , Tai Jun 
Published: September 2022

AbstractEmerging and re‐emerging viruses like influenza virus pose a continuous global public health threat. Vaccines are one of the most effective public health strategies for controlling infectious diseases. However, little is known about the immunological features of vaccination at the single‐cell resolution, including for influenza vaccination. Here, we report the single‐cell transcriptome atlas of longitudinally collected peripheral blood mononuclear cells (PBMCs) in individuals immunized with an inactivated influenza vaccine. Overall, vaccination with the influenza vaccine only had a small impact on the composition of peripheral immune cells, but elicited global transcriptional changes in multiple immune cell subsets. In plasma and B cell subsets, transcriptomic changes, which were mostly involved in antibody production as well as B cell activation and differentiation, were observed after influenza vaccinations. In influenza‐vaccinated individuals, we found a reduction in multiple biological processes (e.g., interferon response, inflammatory response, HLA‐I/II molecules, cellular apoptosis, migration, and cytotoxicity, etc.,) 7 days postvaccination in multiple immune cell subsets. However, 14 days postvaccination, these levels returned to similar levels observed in prevaccination samples. Additionally, we did not observe significant upregulation of pro‐inflammatory response genes and key thrombosis‐related genes in influenza‐vaccinated individuals. Taken together, we report a cell atlas of the peripheral immune response to influenza vaccination and provide a resource for understanding the immunological response mechanisms of influenza vaccination.
Trabecular bone microcrack accumulation in patients treated with bisphosphonates for durations up to 16 years
Authors: Pienkowski David , Wood Constance L. , Malluche Hartmut H. 
Published: September 2022

AbstractThis study quantified the length, number, and density of microcracks in bone from patients treated with bisphosphonates as a function of duration. Anterior iliac crest bone samples from 51 osteoporotic Caucasian females continuously treated with oral bisphosphonates for 1–16 years were obtained by bone biopsy. Samples were histologically processed and analyzed for bone area, microcrack number, and microcrack length. The analyses used statistical modeling and considered patient age, bone mineral density, bone volume/total volume, trabecular thickness, and bone turnover as potential covariates. Microcrack density (number of microcracks/total examined bone area) was linearly related (p = 0.018) to bisphosphonate treatment duration. None of the analyzed covariates contributed significantly to the observed relationship between microcrack density and bisphosphonate treatment duration. Observed increases in microcrack density with increasing bisphosphonate treatment duration is important because increasing levels of microcracks may not only affect bone remodeling but also reduce elastic modulus and are suspected to adversely affect other mechanical properties that may influence fracture risk. The present findings add to our prior results showing changes in bone material properties and modulus with bisphosphonate treatment duration and thereby provide a more comprehensive assessment of the relationship between bisphosphonate treatment duration and bone quality. Statement of Clinical Significance: The present findings provide information guiding clinical use of oral bisphosphonates for post‐menopausal osteoporosis therapy.
How do food authenticity and sensory appeal influence tourist experience? The moderating role of food involvement
Authors: Li Fangxuan (Sam) , Su Qianqian , Ma Jianan 
Published: September 2022

AbstractFood authenticity and sensory appeal are becoming increasingly important research topics in food tourism research. The purpose of this study is to explain how and why food authenticity and sensory appeal contribute to tourists' behavioral intention through affective responses based on stimuli–organism–response (S–O–R) model. This study reports the findings based on a total of 416 questionnaires. The results indicate that memory and destination attachment mediate the relationship between food authenticity and behavioral intention, sensory appeal and behavioral intention. Furthermore, food involvement is identified as a moderator between stimulus factors and affective responses. Implications and suggestions for future research are also discussed.
Land degradation resistance potential of a dry, semiarid region in relation to soil organic carbon stocks, carbon management index, and soil aggregate stability
Authors: Ameer Imran , Kubar Kashif Ali , Ali Qurban , Ali Shahmir , Khan Tamoor , Shahzad Khurram , Riaz Muhammad , Shah Zia‐ul‐hassan , Rajpar Inayatullah , Ahmed Muneer , Talpur Khalid Hussain 
Published: September 2022

AbstractDry stable aggregates, soil organic carbon (SOC) stocks, and aggregate‐associated carbon are measured as vital factors for preserving soil quality. Different land use systems strongly impacts the services of the ecosystem to influence soil degradation and loss of carbon. Little is known about the dry aggregates stability and SOC stocks in the dry, semiarid region of Balochistan, Pakistan or how these resist land degradation. This study aimed to assess the impact of several land‐use systems on SOC stocks, the distribution of soil aggregates, and the carbon management index. The treatments consisted of five land‐use systems, namely, grassland, cropland, fallow land, forests, and vegetation, typically prevail in the region. Three layers of soil were used to sample it (0–15, 15–30, and 30–45 cm) and sieved into five aggregate classes (>8, 8–5, 5–2, 2–0.25, and <0.25 mm). The grasslands had significant higher SOC concentrations (12.83 g kg−1), SOC stocks (19.44 mg ha−1), liability index (0.89 g kg−1), nonlabile C (9.56 g kg−1), labile C (0.35 g kg−1), carbon management index (204.6), and easily oxidizable carbon (3.27 g kg−1), when compared with fallow land. Moreover, grassland and forestland soils contained larger macroaggregates (>0.25 mm), although the fallow land‐use system had a higher degree of micro aggregates (<0.25 mm). We found strong relationship of soil SOC with SOC concentration of soil aggregates and other labile fractions of carbon. Therefore, grassland and forestland promotes the aggregate‐associated SOC and carbon management index by enhancing the soil aggregation and is therefore a possible managing option to develop the SOC sequestration potential of eroded dry soils.
4D Biofabrication of Mechanically Stable Tubular Constructs Using Shape Morphing Porous Bilayers for Vascularization Application
Authors: Trujillo‐Miranda Mairon , Apsite Indra , Agudo Jose A. Rodríguez , Constante Gissela , Ionov Leonid 
Published: September 2022

AbstractThis study reports the fabrication of highly porous electrospun self‐folding bilayers, which fold into tubular structures with excellent mechanical stability, allowing them to be easily manipulated and handled. Two kinds of bilayers based on biocompatible and biodegradable soft (PCL, polycaprolactone) and hard (PHB, poly‐hydroxybutyrate) thermoplastic polymers have been fabricated and compared. Multi‐scroll structures with tunable diameter are obtained after the shape transformation of the bilayer in aqueous media, where PCL‐based bilayer rolled longitudinally and PHB‐based one rolled transversely with respect to the fiber direction. A combination of higher elastic modulus and transverse orientation of fibers with respect to rolling direction allowed precise temporal control of shape transformation of PHB‐bilayer – stress produced by swollen methacrylated hyaluronic acid (HA‐MA) do not relax with time and folding is not affected by the fact that bilayer is fixed in unfolded state in cell culture medium for more than 1 h. This property of PHB‐bilayer allowed cell culturing without a negative effect on its shape transformation ability. Moreover, PHB‐based tubular structure demonstrated superior mechanical stability compared to PCL‐based ones and do not collapse during manipulations that happened to PCL‐based one. Additionally, PHB/HA‐MA bilayers showed superior biocompatibility, degradability, and long‐term stability compared to PCL/HA‐MA.
Channel coordination in a closed‐loop supply chain with fairness concerns under further extended producer responsibility
Authors: Ma Yan , Cheng Susu 
Published: September 2022

AbstractThis paper proposes a further extended producer responsibility system to study the operations of the supply chain with fairness concerns. By comparing four scenarios regarding whether channel members concern fairness, we obtain the following results: the coordinated development can be accomplished for channel members when the dominant producer makes pricing decisions with more consideration for the profit of follower; both the producer and the retailer can adjust the degree of demand information disclosure in some ways to obtain more profits; the further extended producer responsibility system (FEPR) system can serve as an effective low‐carbon development measure that leads to higher emission reduction and end‐products recovery.
Financial and environmental efficiency of CDM projects: Analysis and classification for investment decisions
Authors: Pacagnella Júnior Antônio Carlos , da Silva Henrique Luiz , Bortoletto Wagner Wilson , de Arruda Ignacio Paulo Sergio 
Published: September 2022

AbstractThe main purpose of this paper is to analyze the efficiency of Clean Development Mechanism (CDM) projects implemented worldwide and understand their main characteristics, seeking to support investment decisions and expand the scientific understanding of the financial and environmental impact of these projects. To achieve this goal, a sample of 2352 CDM projects was selected from a United Nations Framework Convention on Climate Change (UNFCCC) database and analyzed first with a two‐stage data envelopment analysis (DEA) model that allowed the evaluation of the financial return and environmental efficiency of these projects. DEA results provide an efficiency ranking that was then analyzed with a classification tree (CHAID algorithm), revealing some main characteristics of the projects with higher efficiencies, like their sizes, locations, and type of CDM. CDMs are projects that demand a significant quantity of resources and effort to produce the expected outcomes, so it is crucial for public managers and investors to know the project profiles that generate the best financial and environmental results. In this sense, this study presents a completely original methodology for this kind of analysis and reveals important insights for these agents and researchers in this field.
Accountability, Test Prep Incentives, and the Design of Math and English Exams
Authors: Riehl Evan , Welch Meredith 
Published: September 2022

AbstractWe examine how incentives for test prep varied between math and English language arts (ELA) on U.S. state accountability exams. We collected data on exam structure for grade 3 to 8 tests in six states that are the setting for most U.S. research in literatures where accountability matters. We show that math exams typically measured ability more precisely for students on the margin of achieving proficiency. This gave educators an incentive to spend more time preparing students for math tests than for ELA tests, consistent with the common finding of larger math effects in the literature.
Imaging of pediatric thyroid tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper
Authors: Squires Judy H. , Martinez‐Rios Claudia , Davis James C. , Dietz Kelly R. , Epelman Monica S. , Lai Hollie A. , Lim‐Dunham Jennifer E. , McDaniel Janice D. , Mhlanga Joyce C. , Pandit‐Taskar Neeta , Parisi Marguerite T. , Trout Andrew T. , Weidman Elizabeth K. , Alazraki Adina L. 
Published: September 2022

AbstractPediatric thyroid cancer is rare in children; however, incidence is increasing. Papillary thyroid cancer and follicular thyroid cancer are the most common subtypes, comprising about 90% and 10% of cases, respectively. This paper provides consensus imaging recommendations for evaluation of pediatric patients with thyroid cancer at diagnosis and during follow‐up.
3Dprinting of a compositeiPP/quill of chicken feathers functionalized with pimelic acid
Authors: Patiño‐Almanza Rodrigo , Flores‐Hernandez Cynthia G. , Rivera‐Armenta José Luis , Strachota Adam , Almendarez‐Camarillo Armando 
Published: September 2022

AbstractIn this work, the thermomechanical properties of an isotactic polypropylene (iPP)/quill composite were evaluated. This reinforcement was added at 0.5, 1.0 and 5.0 wt% in the iPP matrix. The reinforcement was previously subjected to alkaline treatment with NaOH (QT) and chemical functionalization with pimelic acid (PA) to produce an effective β‐crystal nucleating agent. This functionalization was characterized by Fourier transform infrared spectroscopy (FTIR), showing the presence of a new band at 1571 cm−1associated with the carboxylate group of pimelic acid, indicating a bond between PA and the quill surface. The internal geometry of the specimens obtained by 3D printing were studied by scanning electron spectroscopy (SEM). The effectiveness of the modified reinforcement as a promoter of the β‐crystalline phase was evaluated by differential scanning calorimetry (DSC) and wide angle X‐ray scattering (WAXD) under non‐isothermal crystallization conditions due to the 3D printing process. The composite that showed a higher index was 1.0% with a value of 64% by DSC and 65% by WAXD. Furthermore, the thermomechanical properties were characterized by dynamic mechanical analysis (DMA) where, for the 0.5% and 1.0% composites, the storage modulus (E') was higher compared to neat iPP. However, for the 5.0% composite theE' values were lower.
Crystallization property, mechanical performance and enzymatic degradation behavior of PBS copolyesters modified by 2‐methyl‐1,3‐propanediol
Authors: Jiang Sen , Wang Liyan , Zheng Rongrong , Chong Yunsheng , Chen Yanming 
Published: September 2022

AbstractThe poly(butylene succinate) (PBS) copolyesters modified by 2‐methyl‐1,3‐propanediol (MPO), that is poly(butylene succinate‐co‐methyl propylene succinate) (PBMS), were synthesized by direct esterification‐melt polycondensation method. 1H NMR showed the PBMS molecules contain two repeating structural units, the butylene succinate (BS) and the 2‐methyl‐1,3‐propylene succinate (MS). The crystalline properties of PBMS were characterized by DSC, POM, and XRD. The results showed the relative crystallinity of PBMS decreases from 45.12% to 38.2%, the size of spherulites also decreases, and the crystallization ability becomes weaker compared with PBS. The water contact angle test proved the surface hydrophilicity of PBMS is improved. The impact strength of PBMS increases from 3.9 to 24.6 kJ/m2, and its elongation at break increases from 10.5% to 71.2%, and the transition from brittle fracture to ductile fracture is achieved. The study of enzymatic degradation found that the enzymatic degradation rate of PBMS copolyesters increases significantly with the increase of MPO content. Within 25 days of degradation, the weight loss rate of PBS after degradation is 38.18%, while that of PBMS reaches 100%. Finally, it was also observed the enzymatic degradation of PBS and PBMS starts from the amorphous region and abides by the regular pattern from the periphery to the middle and from the surface to the interior.
Performance evaluation of thermally aged ATH and BN co‐doped silicone rubber nano‐micro composites for power cable applications
Authors: Vangapandu Dhanunjaya Naidu , Paul Moutusi , Mishra Palash , Sarathi Ramanujam , Kornhuber Stefan , Thapliyal Shivraman 
Published: September 2022

AbstractPower cables are intended to operate at high temperatures over a long period which may change the performance of silicone rubber insulation used in high voltage cable accessories. Therefore, in the current study, to enhance the properties of silicone rubber, alumina try‐hydrate (ATH) and boron nitride (BN) micro and nanoparticles were added to the silicone rubber matrix. The synthesized undoped silicone rubber, silicone rubber with 40 wt% micro ATH, 7 wt% nano BN, and 10 wt% micro ATH + 5 wt% nano BN composites were thermally aged for 600 h at 180ºC. The composite properties were analyzed through electrical, thermal, and physicochemical techniques. To assess the electrical characteristics, water droplet‐initiated corona discharge studies as per IEC 60112 were conducted and leakage current, corona inception voltage, and erosion resistance were evaluated. A deep learning technique also was employed for the prediction of erosion resistance of the samples. Further, to examine the surface texture and chemical changes on the surface of the material, 3‐D microscopy and Fourier transform infrared spectroscopy (FTIR) was adopted. Finally, thermal distribution analysis was performed for all the composites by infrared thermography. The results demonstrated the suitability of nano‐micro co‐doped composites over nanocomposites and micro composites for power cable applications.
Ostrinia furnacalisPBP2 solution NMR structure: Insight into ligand binding and release mechanisms
Authors: Dahal Salik R. , Lewellen Jacob L. , Ayyappan Shine , Chaudhary Bharat P. , Nukala Viswanath , Mohanty Smita 
Published: September 2022

AbstractOstrinia furnacalis is an invasive lepidopteran agricultural pest that relies on olfaction for mating and reproduction. Male moths have an extremely sensitive olfactory system that can detect the sex pheromones emitted by females over a great distance. Pheromone‐binding proteins present in the male moth antenna play a key role in the pheromone uptake, transport, and release at the dendritic membrane of the olfactory neuron. Here, we report the first high‐resolution NMR structure of a pheromone‐binding protein from an Ostrinia species at pH 6.5. The core of the Ostrinia furnacalis PBP2 (OfurPBP2) consists of six helices, α1a (2–14), α1b (16–22), α2 (27–37), α3 (46–60), α4 (70–80), α5 (84–100), and α6 (107–124) surrounding a large hydrophobic pocket. The structure is stabilized by three disulfide bridges, 19–54, 50–108, and 97–117. In contrast to the unstructured C‐terminus of other lepidopteran PBPs, the C‐terminus of OfurPBP2 folds into an α‐helix (α7) at pH 6.5. The protein has nanomolar affinity towards both pheromone isomers. Molecular docking of both pheromones, E‐12 and Z‐12‐tetradecenyl acetate, to OfurPBP2 revealed that the residues Met5, Lys6, Met8, Thr9, Phe12, Phe36, Trp37, Phe76, Ser115, Phe118, Lys119, Ile122, His123, and Ala128 interact with both isomers, while Thr9 formed a hydrogen bond with the acetate head group. NMR structure and thermal unfolding studies with CD suggest that ligand release at pH 4.5 is likely due to the partial unfolding of the protein.
A further note on the exponentially weighted moving average control charts for monitoring gradual shifts in a process mean
Authors: Maghsoodloo Saeed , Silva Daniel F. 
Published: September 2022

AbstractThis article provides a historical discussion of exponentially weighted moving average (EWMA) control charts and makes minor modifications. Because the charting statistics are correlated, both the autocovariance and autocorrelations functions are derived; it is determined that the steady‐state autocorrelation also diminishes geometrically. Assuming normality of individual observations, two successive EWMA statistics have the bivariate normal distribution with an autocorrelation of lag 1. We then used the bivariate normal density to approximate the type II error probability, thereby obtaining the first‐order conditional average run length.
A simple approximate solution for the H3+ ion
Authors: Pérez Paz Alejandro 
Published: September 2022

AbstractHere I derive analytical expressions for the total energy of the cation in its equilateral and linear geometries. The theoretical model consists of a simple variational trial wavefunction made of the sum of three 1S Gaussian functions, each centered on each nucleus. Detailed derivations are presented and the advantages and limitations of this simple model are discussed. The correctness of the results was verified independently via Monte Carlo integration. This simple model correctly predicts and rationalizes the preference of for the equilateral geometry rather than the linear configuration. Despite its simplicity, the calculated HH bond length (R = 0.9088 Å) and breathing vibrational frequency (ν1 = 3276.59 cm−1) for equilateral ion are in good agreement with high‐level ab initio methods and the experiment, respectively.
Gelatinization and Retrogradation Properties of Wheat Starch with Added Konjac Glucomannan or Artemisia sphaerocephala Krasch. Gum
Authors: Zou Yong , Zhang Shuai , Chen Yuanyuan , Zeng Yunjun , Zhong Geng , Zhao Yi 
Published: September 2022

AbstractThis work evaluates the effect of the various proportions of konjac glucomannan (KGM) and Artemisia sphaerocephala Krasch. Gum (ASKG) on the gelatinization structure, and retrogradation characteristics of wheat starch (WS). The Rapid Viscosity Analyzer (RVA), iodine colorimetric reaction, Scanning Electron Microscope (SEM), Fourier transform infrared (FTIR) spectroscopy, X‐ray diffraction analysis (XRD), and dynamic time sweep measurements, among other instruments are used to evaluate the structural properties, gelatinization, and retrogradation characteristics of WS, KGM/WS mixture, and ASKG/WS mixture. The addition of KGM/ASKG to WS improves the peak viscosity, final viscosity, breakdown value, setback value, swelling power, G′ and G″ values, and tan δ. Meanwhile, the amount of amylose leached, retrogradation enthalpy, and relative crystallinity reduced, and the gel structure appears to become more consistent and stable, with an increase in the number of inter‐ and intramolecular hydrogen bonds. These findings show that the presence of an interaction between KGM/ASKG and WS, boosted gel intensity and textural qualities while suppressing short and long‐term WS retrogradation.
Using computational essays to foster disciplinary epistemic agency in undergraduate science
Authors: Odden Tor Ole B. , Silvia Devin W. , Malthe‐Sørenssen Anders 
Published: September 2022

AbstractThis article reports on a study investigating how computational essays can be used to help students in higher education STEM take up disciplinary epistemic agency—cognitive control and responsibility over one's own learning within the scientific disciplines. Computational essays are a genre of scientific writing that combine live, executable computer code with narrative text to present a computational model or analysis. The study took place across two contrasting university contexts: an interdisciplinary data science and modeling course at a large research university in the Midwestern United States, and a third‐semester physics course at a large research university in Scandinavia. Over the course of a semester, computational essays were simultaneously and independently used in both courses, and comparable datasets of student artifacts and retrospective interviews were collected from both student populations. These data were analyzed using a framework that operationalized the construct of disciplinary epistemic agency across the dimensions of programming, inquiry, data analysis and modeling, and communication. Based on this analysis, we argue that computational essays can be a useful tool for fostering disciplinary epistemic agency within higher education science due to their combination of adaptability and disciplinary authenticity. However, we also argue that educational contexts, scaffolding, expectations, and student backgrounds can constrain and influence the ways in which students choose to take up epistemic agency.