bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and Safety of Ibrutinib for Chronic Lymphocytic Leukemia in Routine Clinical Practice: 3-Year Follow-up of the Belgian Ibrutinib Real-World Data (BiRD) Study
Authors: Janssens Ann , Berneman Zwi N. , Offner Fritz , Snauwaert Sylvia , Mineur Philippe , Vanstraelen Gaetan , Meers Stef , Spoormans Isabelle , Bron Dominique , Vande Broek Isabelle , Van Bogaert Charlotte , De Beleyr Birgit , Smet Ann , Nielsen Lasse , Wapenaar Robert , André Marc 
Published: October 2022

AbstractThe multicenter observational BiRD study investigated the real-world effectiveness and safety of ibrutinib in patients with chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL) and Waldenström’s macroglobulinemia (WM) in Belgium. This interim analysis reports results for patients with CLL, with a median follow-up of 34 months. Overall, patients had predominantly relapsed/refractory disease (73%) and were elderly (median age 72 years) with high-risk features such as del17p and/or TP53 mutations (59%). Patients were included either prospectively or retrospectively, and the total patient population effectiveness results were adjusted with left truncation. In the effectiveness population (N = 221: prospective, n = 71; retrospective, n = 150), the overall response rate was 90.0%. Median progression-free survival was 38.3 months (prospective, not estimable; retrospective, 51.5 months) and median overall survival was not yet estimable in the total, prospective and retrospective groups. Treatment-emergent adverse events (TEAEs) for the prospective and retrospective groups are reported separately. Any-grade TEAEs of interest in the prospective/retrospective groups included infections (67.1%/60.1%), diarrhea (20.5%/10.5%), hypertension (16.4%/9.8%) and atrial fibrillation (12.3%/7.2%). Major bleeding was reported in 5.5%/3.3% of prospective/retrospective patients, with little difference observed between those receiving versus not receiving antithrombotic treatment. Discontinuations due to toxicity were reported in 10.5% of patients. Results from this interim analysis show treatment with ibrutinib to be effective and tolerable, with no new safety signals observed. Future analyses will report on longer-term follow-up.
Equilibrium states for non-transitive random open and closed dynamical systems
Authors: ATNIP JASON , FROYLAND GARY , GONZÁLEZ-TOKMAN CECILIA , VAIENTI SANDRO 
Published: October 2022

AbstractWe prove a random Ruelle–Perron–Frobenius theorem and the existence of relative equilibrium states for a class of random open and closed interval maps, without imposing transitivity requirements, such as mixing and covering conditions, which are prevalent in the literature. This theorem provides the existence and uniqueness of random conformal and invariant measures with exponential decay of correlations, and allows us to expand the class of examples of (random) dynamical systems amenable to multiplicative ergodic theory and the thermodynamic formalism. Applications include open and closed non-transitive random maps, and a connection between Lyapunov exponents and escape rates through random holes. We are also able to treat random intermittent maps with geometric potentials.
Gender, Power, and Female Revolutionaries
Authors: Snyder Emily C. 
Published: October 2022

This essay reviews the following works:Women and the Cuban Insurrection: How Gender Shaped Castro’s Victory. By Lorraine Bayard de Volo. New York: Cambridge University Press, 2018. Pp. xi + 304. $25.99 paperback. ISBN: 9781316630846.Buenas al pleito: Mujeres en la rebelión de Sandino. By Alejandro Bendaña. Managua: Anamá Ediciones, 2019. Pp. 302. $25.00 paperback. ISBN: 9789992475652.Beatriz Allende: A Revolutionary Life in Cold War Latin America. By Tanya Harmer. Chapel Hill: University of North Carolina Press, 2020. Pp. x + 384. $34.95 hardcover. ISBN: 9781469654294.Laboring for the State: Women, Family, and Work in Revolutionary Cuba, 1959–1971. By Rachel Hynson. New York: Cambridge University Press, 2020. Pp. xvii + 332. $34.95 hardcover. ISBN: 9781107188679.Students of Revolution: Youth, Protest, and Coalition Building in Somoza-Era Nicaragua. By Claudia Rueda. Austin: University of Texas Press, 2019. Pp. xii + 304. $45.00 hardcover. ISBN: 9781477319307.Sandinistas: A Moral History. By Robert J. Sierakowski. Notre Dame, IN: University of Notre Dame Press, 2019. Pp. 356. $35.00 hardcover. ISBN: 9780268106898.Celia Sánchez Manduley: The Life and Legacy of a Cuban Revolutionary. By Tiffany A. Sippial. Chapel Hill: University of North Carolina Press, 2020. Pp. xxi + 288. $29.95 paperback. ISBN: 9781469654607.Revolution and Reaction: The Diffusion of Authoritarianism in Latin America. By Kurt Weyland. Cambridge: Cambridge University Press, 2019. Pp. x + 310. $34.99 paperback. ISBN: 9781108728836.
New characterisations of bicentric quadrilaterals
Authors: Josefsson Martin 
Published: October 2022

A bicentric quadrilateral is a convex quadrilateral that can have both an incircle (it is tangential) and a circumcircle (it is cyclic), see Figure 1. We know of only a dozen characterisations of bicentric quadrilaterals published before. In all of them the starting point is either a tangential or a cyclic quadrilateral, which then must satisfy some condition in order also to be of the other type. Before we proceed to prove seven new such necessary and sufficient conditions for bicentric quadrilaterals, we review one characterisation and one property of tangential quadrilaterals that we will apply later.
Toward a classification of the supercharacter theories of Cp × Cp
Authors: Burkett Shawn T. , Lewis Mark L. 
Published: October 2022

AbstractIn this paper, we study the supercharacter theories of elementary abelian $p$-groups of order $p^{2}$. We show that the supercharacter theories that arise from the direct product construction and the $\ast$-product construction can be obtained from automorphisms. We also prove that any supercharacter theory of an elementary abelian $p$-group of order $p^{2}$ that has a non-identity superclass of size $1$ or a non-principal linear supercharacter must come from either a $\ast$-product or a direct product. Although we are unable to prove results for general primes, we do compute all of the supercharacter theories when $p = 2,\, 3,\, 5$, and based on these computations along with particular computations for larger primes, we make several conjectures for a general prime $p$.
Canto Porque es Necesario Cantar: The New Song Movement in Chile, 1973–1983
Authors: Morris Nancy 
Published: October 2022

“Para el camino” Canto a la angustia y a las alegrias. Canto porque es necesario can tar para ir dejando una huella en los dias, para ir diciendo cosas prohibidas.“For the Road” I sing of anguish and joy. I sing because it's necessary to sing to leave my mark on time, to say forbidden things.Latin American New Song is distinct from the usual stereotypes of Latin American popular music. Songs such as “Para el camino” do not fit into the common categories of salsa, ballads, Spanish-language versions of U.S. hit songs or popularized traditional styles such as the ranchera and cumbia. Although New Song is not as well known as the more typical styles, its greater social significance has achieved an impact in Latin America far beyond the musical realm.
Restoring the orangutan in a Whole- or Half-Earth context
Authors: Meijaard Erik , Sheil Douglas , Sherman Julie , Chua Liana , Ni'matullah Safwanah , Wilson Kerrie , Ancrenaz Marc , Liswanto Darmawan , Wich Serge A. , Goossens Benoit , Kühl Hjalmar S. , Voigt Maria , Rayadin Yaya , Kurniawan Yuyun , Trianto Agus , Priatna Dolly , Banes Graham L. , Massingham Emily , Payne John , Marshall Andrew J. 
Published: October 2022

AbstractVarious global-scale proposals exist to reduce the loss of biological diversity. These include the Half-Earth and Whole-Earth visions that respectively seek to set aside half the planet for wildlife conservation or to diversify conservation practices fundamentally and change the economic systems that determine environmental harm. Here we assess these visions in the specific context of Bornean orangutansPongo pygmaeusand their conservation. Using an expert-led process we explored three scenarios over a 10-year time frame: continuation of Current Conditions, a Half-Earth approach and a Whole-Earth approach. In addition, we examined a 100-year population recovery scenario assuming 0% offtake of Bornean orangutans. Current Conditions were predicted to result in a population c. 73% of its current size by 2032. Half-Earth was judged comparatively easy to achieve and predicted to result in an orangutan population of c. 87% of its current size by 2032. Whole-Earth was anticipated to lead to greater forest loss and ape killing, resulting in a prediction of c. 44% of the current orangutan population for 2032. Finally, under the recovery scenario, populations could be c. 148% of their current size by 2122. Although we acknowledge uncertainties in all of these predictions, we conclude that the Half-Earth and Whole-Earth visions operate along different timelines, with the implementation of Whole-Earth requiring too much time to benefit orangutans. None of the theorized proposals provided a complete solution, so drawing elements from each will be required. We provide recommendations for equitable outcomes.
Disjunctures in practice: ethnographic observations of orthopaedic ward practices in the care of older adults with hip fracture and presumed cognitive impairment
Authors: Cross Jane L. , Backhouse Tamara , Hammond Simon P. , Penhale Bridget , Scheibl Fiona , Lambert Nigel , Varley Anna , Fox Chris , Poland Fiona M. 
Published: October 2022

AbstractOrganisational priorities for health care focus on efficiency as the health and care needs of populations increase. But evidence suggests that excessive planning can be counterproductive, leading to resistance from staff and patients, particularly those living with cognitive impairment. The current paper adds to this debate reporting an Institutional Ethnography of staff delivering care for older patients with cognitive impairment on acute orthopaedic wards in three National Health Service hospitals in the United Kingdom. A key problematic identified in this study is the point of disjuncture seen between the actualities of staff experience and intentions of protocols and policies. We identified three forms of disjuncture typified as: ‘disruptions’, where sequenced care was interrupted by patient events; ‘discontinuities’, where divisions in professional culture, space or time interrupted sequenced tasks; and ‘dispersions’, where displaced objects or people interrupted sequenced care flow. Arguably disruption is an integral characteristic of care work; it follows that to enable staff to flourish, organisations need to confer staff the autonomy to address systemic disruptions rather than attempt to eradicate them. Ultimately, organisational representations of ‘good practice’ as readily joined up, impose a care standard ‘stereotype’ that obscures rather than clarifies the interactional problems encountered by staff.
The combinator M and the Mockingbird lattice
Authors: Giraudo Samuele 
Published: October 2022

AbstractWe study combinatorial and order theoretic structures arising from the fragment of combinatory logic spanned by the basic combinator
${{\mathbf{M}}}$
. This basic combinator, named as the Mockingbird by Smullyan, is defined by the rewrite rule
${{\mathbf{M}}} \mathsf{x}_1 \to \mathsf{x}_1 \mathsf{x}_1$
. We prove that the reflexive and transitive closure of this rewrite relation is a partial order on terms on
${{\mathbf{M}}}$
and that all connected components of its rewrite graph are Hasse diagram of lattices. This last result is based on the introduction of new lattices on duplicative forests, which are sorts of treelike structures. These lattices are not graded, not self-dual, and not semi-distributive. We present some enumerative properties of these lattices like the enumeration of their elements, of the edges of their Hasse diagrams, and of their intervals. These results are derived from formal power series on terms and on duplicative forests endowed with particular operations.
MRI evaluation of right heart functions in children with mild cystic fibrosis
Authors: Temur Hafize Otcu , Alkan Alpay , Yozgat Can Yilmaz , Cakir Erkan , Yazan Hakan , Yabul Fatma Celik , Cesme Dilek Hacer , Yozgat Yilmaz 
Published: October 2022

AbstractBackground:This study aimed to assess the ventricular anatomy, function of the right ventricle, and the haemodynamic findings of pulmonary artery in children with cystic fibrosis using cardiac MRI.Patients:This prospective study consisted of 32 children with mild cystic fibrosis and 30 age-matched healthy control participants.Methods:Cardiac MRI was used to assess right ventricular volumes, anatomy, and function and to assessment of haemodynamic findings of pulmonary artery in the control and study groups. Haemodynamic findings of pulmonary arteries were determined using pulmonary arteries peak velocity (cm/s), and pulmonary arteries time-to-peak velocity (ms) and pulmonary artery systolic pressure. All data of children with mild cystic fibrosis were compared with those of 30 age-matched healthy control group participants.Results:Our patients and their age-matched controls were aged from 6 to 17 years and from 7 to 15 years, respectively. We found that ejection fraction (%), cardiac output (L/ml), cardiac output (L/ml/m2), and systolic volume (ml/m2) were significantly lower in children with cystic fibrosis (p < 0.01). Right ventricular anterior wall thickness (mm) was significantly higher in children with cystic fibrosis (p = 0.01). No significant difference was observed between the haemodynamic parameters of pulmonary artery in the patient group.Conclusion:In our study, cardiac MRI was used to investigate whether the right ventricle was affected functionally and anatomically in children with mild cystic fibrosis. We detected a significant decrease in right ventricular systolic functions and notable alterations in the right ventricular geometry of children with mild cystic fibrosis. These alterations usually manifest themselves as hypertrophy of the right ventricle. Our study’s results demonstrate no relationship between the development of pulmonary hypertension in mild cystic fibrosis children.
RapidPlan models for prostate radiotherapy treatment planning with 10-MV photon beams
Authors: Pupillo Francesco , Piliero Maria Antonietta , Casiraghi Margherita , Bellesi Luca , Presilla Stefano 
Published: October 2022

Abstract

Introduction:
The RapidPlan is a radiotherapy planning tool that uses a dataset of approved plans to predict the dose distribution and automatically generates the dose–volume constraints for optimisation of the new plan. This study compares three strategies of model building for the treatment of prostate cancer with the 10-MV photon beam.

Methods:
Three models for prostate treatment were compared: Model 6X, Model10X and Model6Xrefined. Model6X is already used in our department and was trained on treatment plans based on the 6-MV photon beam. Model10X was trained on treatment plans based on the 10-MV photon beam and manually optimised by an experienced medical physicist. Finally, Model6Xrefined was trained on plans automatically created by the Model6X, but using the 10-MV photon beam. The three models were used to generate 25 new plans with the 10-MV photon beam.

Results:
Model10X generated plans with 2 Gy lower mean dose to bladder-PTV and rectum-PTV volumes and 8% lower V15Gy at bladder and rectum volumes, although the number of monitor units increased by 170 on average.

Conclusions:
The model trained on manually optimised plans generated plans with higher normal tissue sparing. However, model building is a time-consuming process, so a cost–benefit balance should be performed.
THE LOGIC OF HYPERLOGIC. PART B: EXTENSIONS AND RESTRICTIONS
Authors: KOCUREK ALEXANDER W. 
Published: October 2022

AbstractThis is the second part of a two-part series on the logic of hyperlogic, a formal system for regimenting metalogical claims in the object language (even within embedded environments). Part A provided a minimal logic for hyperlogic that is sound and complete over the class of all models. In this part, we extend these completeness results to stronger logics that are sound and complete over restricted classes of models. We also investigate the logic of hyperlogic when the language is enriched with hyperintensional operators such as counterfactual conditionals and belief operators.
Design of multi-band and high radiation intensity piezoelectric antenna based on external circuit
Authors: Zhang Yong , Yan Zhongming , Dong Biao , Wang Yu , Zhou Hongcheng 
Published: October 2022

AbstractThis paper presents a novel method to improve the working bandwidth and radiation intensity of piezoelectric antenna by using external circuit. This method makes the piezoelectric antenna combined with roles of high radiation intensity and multiple resonant frequencies without changing the structural size of the piezoelectric antenna. The experimental results show that, compared with the original piezoelectric antenna, the tuning range of the resonant frequency of the piezoelectric antenna caused by the series capacitance and inductance is +13.6 and −24%, respectively. The series inductance will produce new resonance frequency, which provides a new method for the multi-band operation of the piezoelectric antenna. The LLC (series and parallel circuit) composite circuit can increase the number of resonant frequencies of the piezoelectric antenna from 1 to 3, and the S11 at the resonant frequencies are all lower than −10 dB, and the radiated magnetic field of the piezoelectric antenna is increased by 42.3% at least. This method makes the piezoelectric antenna have the dual functions of high radiation intensity and multi-band, which has great significance for broadening the application field of piezoelectric antenna.
Inhibition of Mps1 kinase enhances taxanes efficacy in castration resistant prostate cancer
Authors: Sarwar Sadia , Morozov Viacheslav M. , Purayil Hamsa , Daaka Yehia , Ishov Alexander M. 
Published: October 2022

AbstractAndrogen ablation therapy is the standard of care for newly diagnosed prostate cancer (PC) patients. PC that relapsed after hormonal therapy, referred to as castration-resistant PC (CRPC), often presents with metastasis (mCRPC) and is the major cause of disease lethality. The few available therapies for mCRPC include the Taxanes Docetaxel (DTX) and Cabazitaxel (CBZ). Alas, clinical success of Taxanes in mCRPC is limited by high intrinsic and acquired resistance. Therefore, it remains essential to develop rationally designed treatments for managing therapy-resistant mCRPC disease. The major effect of Taxanes on microtubule hyper-polymerization is a prolonged mitotic block due to activation of the Spindle Assembly Checkpoint (SAC). Taxane-sensitive cells eventually inactivate SAC and exit mitosis by mitotic catastrophe, resulting in genome instability and blockade of proliferation. Resistant cells remain in mitotic block, and, upon drug decay, resume mitosis and proliferation, underlying one resistance mechanism. In our study we explored the possibility of forced mitotic exit to elevate Taxane efficacy. Inactivation of the SAC component, mitotic checkpoint kinase Mps1/TTK with a small molecule inhibitor (Msp1i), potentiated efficacy of Taxanes treatment in both 2D cell culture and 3D prostasphere settings. Mechanistically, Mps1 inhibition forced mitotic catastrophe in cells blocked in mitosis by Taxanes. Androgen receptor (AR), the main driver of PC, is often mutated or truncated in mCRPC. Remarkably, Mps1i significantly potentiated CBZ cytotoxicity regardless of AR status, in both AR-WT and in AR-truncated CRPC cells. Overall, our data demonstrate that forced mitotic exit by Mps1 inhibition potentiates Taxanes efficacy. Given that several Mps1i’s are currently in different stages of clinical trials, our results point to Mps1 as a new therapeutic target to potentiate efficacy of Taxanes in mCRPC patients.
Manganese-driven CoQ deficiency
Authors: Diessl Jutta , Berndtsson Jens , Broeskamp Filomena , Habernig Lukas , Kohler Verena , Vazquez-Calvo Carmela , Nandy Arpita , Peselj Carlotta , Drobysheva Sofia , Pelosi Ludovic , Vögtle F.-Nora , Pierrel Fabien , Ott Martin , Büttner Sabrina 
Published: October 2022

AbstractOverexposure to manganese disrupts cellular energy metabolism across species, but the molecular mechanism underlying manganese toxicity remains enigmatic. Here, we report that excess cellular manganese selectively disrupts coenzyme Q (CoQ) biosynthesis, resulting in failure of mitochondrial bioenergetics. While respiratory chain complexes remain intact, the lack of CoQ as lipophilic electron carrier precludes oxidative phosphorylation and leads to premature cell and organismal death. At a molecular level, manganese overload causes mismetallation and proteolytic degradation of Coq7, a diiron hydroxylase that catalyzes the penultimate step in CoQ biosynthesis. Coq7 overexpression or supplementation with a CoQ headgroup analog that bypasses Coq7 function fully corrects electron transport, thus restoring respiration and viability. We uncover a unique sensitivity of a diiron enzyme to mismetallation and define the molecular mechanism for manganese-induced bioenergetic failure that is conserved across species.
Spatially structured eco-evolutionary dynamics in a host-pathogen interaction render isolated populations vulnerable to disease
Authors: Höckerstedt Layla , Numminen Elina , Ashby Ben , Boots Mike , Norberg Anna , Laine Anna-Liisa 
Published: October 2022

AbstractWhile the negative effects that pathogens have on their hosts are well-documented in humans and agricultural systems, direct evidence of pathogen-driven impacts in wild host populations is scarce and mixed. Here, to determine how the strength of pathogen-imposed selection depends on spatial structure, we analyze growth rates across approximately 4000 host populations of a perennial plant through time coupled with data on pathogen presence-absence. We find that infection decreases growth more in the isolated than well-connected host populations. Our inoculation study reveals isolated populations to be highly susceptible to disease while connected host populations support the highest levels of resistance diversity, regardless of their disease history. A spatial eco-evolutionary model predicts that non-linearity in the costs to resistance may be critical in determining this pattern. Overall, evolutionary feedbacks define the ecological impacts of disease in spatially structured systems with host gene flow being more important than disease history in determining the outcome.