bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROFIL PENGELOLAAN EMERGENCY TROLLEY DI INSTALASI GAWAT DARURAT (IGD) RUMAH SAKIT UMUM DAERAH Dr.M.YUNUS BENGKULU
Authors: Sihotang Febrianti 
Published: June 2022

Emergency trolley is a trolley that contains equipment and medicines for emergencies, where there is a sudden and unexpected deterioration in the clinical condition of the patient which can immediately cause death or cause long-term health so that immediate intervention or resuscitation is needed. Good management of emergency trolley can improve the quality of health services in the environment of Dr. M.Yunus Bengkulu Hospital, especially emergency services. The research has been conducted on the management of emergency trolley in the Emergency Room of Dr. M.Yunus Bengkulu Hospital. Emergency trolley at Dr. M.Yunus Bengkulu Hospital guides and applies emergency trolley management standards according to procedures so that the quantity and quality of storage and completeness are maintained. The purpose of this research is to determine the readiness and availability of emergency trolley management standards, especially in the Emergency Room Installation Dr. M.Yunus Bengkulu Hospital. This research is descriptive in nature with a qualitative approach, primary data collection through direct observation, comprising of observing human resources, facilities and infrastructure as well as the process of managing an emergency trolley at RSUD Dr. M.Yunus Bengkulu Hospital. Secondary data collection is conducted through tracing guidelines or procedures for managing emergency trolley used, as well as documents related to management of emergency trolley at RSUD Dr. M.Yunus Bengkulu Hospital. The results of the study are compiled and presented in the form of a checklist table of observations and in the form of a narrative about human resources, facilities and infrastructure as well as the process of managing an emergency trolley at Dr. M.Yunus Bengkulu Hospital.
Synthesis and Biological Activity Evaluation of 2-Cyanopyrrole Derivatives as Potential Tyrosinase Inhibitors
Authors: Hu Ya-Guang , Gao Zhu-Peng , Zheng Ying-Ying , Hu Chun-Mei , Lin Jing , Wu Xiao-Zheng , Zhang Xin , Zhou Yong-Sheng , Xiong Zhuang , Zhu Dao-Yong 
Published: June 2022

In order to find potential inhibitors of tyrosinase, two series of pyrrole derivatives A (1–17) and B (1–8) were synthesized and screened for their inhibitory activities on tyrosinase. Most of the 2-cyanopyrrole derivatives exhibited effective inhibitory activities. In particular, A12 exhibited the strongest inhibitory activities, with the IC50 values of 0.97 μM, which is ∼30 times stronger than the reference inhibitor kojic acid (IC50: 28.72 μM). The inhibitory mechanism analysis results revealed that A12 was a reversible and mixed-type inhibitor. Molecular docking experiments clarified the interaction between A12 with tyrosinase. Furthermore, A12 (100 μM) presented effective inhibitory effect on tyrosinase in B16 melanoma cells with inhibition of 33.48%, which was equivalent to that of Kojic acid (39.81%). Accordingly, compound A12 may serve as the lead structure for the further design of potent tyrosinase inhibitors. Molecular docking studies confirmed the interaction between the compound and tyrosinase.
Comprehensive Proteomics Profiling Identifies Patients With Late Gadolinium Enhancement on Cardiac Magnetic Resonance Imaging in the Hypertrophic Cardiomyopathy Population
Authors: Lander Bradley S. , Zhao Yanling , Hasegawa Kohei , Maurer Mathew S. , Tower-Rader Albree , Fifer Michael A. , Reilly Muredach P. , Shimada Yuichi J. 
Published: June 2022

IntroductionIn hypertrophic cardiomyopathy (HCM), late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) represents myocardial fibrosis and is associated with sudden cardiac death. However, CMR requires particular expertise and is expensive and time-consuming. Therefore, it is important to specify patients with a high pre-test probability of having LGE as the utility of CMR is higher in such cases. The objective was to determine whether plasma proteomics profiling can distinguish patients with and without LGE on CMR in the HCM population.Materials and MethodsWe performed a multicenter case-control (LGE vs. no LGE) study of 147 patients with HCM. We performed plasma proteomics profiling of 4,979 proteins. Using the 17 most discriminant proteins, we performed logistic regression analysis with elastic net regularization to develop a discrimination model with data from one institution (the training set; n = 111) and tested the discriminative ability in independent samples from the other institution (the test set; n = 36). We calculated the area under the receiver-operating-characteristic curve (AUC), sensitivity, and specificity.ResultsOverall, 82 of the 147 patients (56%) had LGE on CMR. The AUC of the 17-protein model was 0.83 (95% confidence interval [CI], 0.75–0.90) in the training set and 0.71 in the independent test set for validation (95% CI, 0.54–0.88). The sensitivity of the training model was 0.72 (95% CI, 0.61–0.83) and the specificity was 0.78 (95% CI, 0.66–0.90). The sensitivity was 0.71 (95% CI, 0.49–0.92) and the specificity was 0.74 (95% CI, 0.54–0.93) in the test set. Based on the discrimination model derived from the training set, patients in the test set who had high probability of having LGE had a significantly higher odds of having LGE compared to those who had low probability (odds ratio 29.6; 95% CI, 1.6–948.5; p = 0.03).ConclusionsIn this multi-center case-control study of patients with HCM, comprehensive proteomics profiling of 4,979 proteins demonstrated a high discriminative ability to distinguish patients with and without LGE. By identifying patients with a high pretest probability of having LGE, the present study serves as the first step to establishing a panel of circulating protein biomarkers to better inform clinical decisions regarding CMR utilization.
Colchicine for the Treatment of Cardiac Injury in Hospitalized Patients With Coronavirus Disease-19
Authors: Rabbani Amir , Rafique Asim , Wang Xiaoyan , Campbell Danielle , Wang Daniel , Brownell Nicholas , Capdevilla Kenia , Garabedian Victoria , Chaparro Sandra , Herrera Raul , Parikh Rushi V. , Ardehali Reza 
Published: June 2022

IntroductionThe impact of colchicine on hospitalized patients with Coronavirus disease-19 (COVID-19) related cardiac injury is unknown.Materials and MethodsIn this multicenter randomized controlled open-label clinical trial, we randomized hospitalized adult patients with documented COVID-19 and evidence of cardiac injury in a 1:1 ratio to either colchicine 0.6 mg po twice daily for 30 days plus standard of care or standard of care alone. Cardiac injury was defined as elevated cardiac biomarkers, new arrhythmia, new/worsened left ventricular dysfunction, or new pericardial effusion. The primary endpoint was the composite of all-cause mortality, need for mechanical ventilation, or need for mechanical circulatory support (MCS) at 90 days. Key secondary endpoints included the individual components of the primary endpoint and change in and at least 2-grade reduction in the World Health Organization (WHO) Ordinal Scale at 30 days. The trial is registered with clinicaltrials.gov (NCT04355143).ResultsWe enrolled 93 patients, 48 patients in the colchicine arm and 45 in the control arm. There was no significant difference in the primary outcome between the colchicine and control arms (19 vs. 15%, p = 0.78), nor in the individual components of all-cause mortality (17 vs. 15%, p = 1.0) and need for mechanical ventilation (8 vs. 5%, p = 0.68); no patients in either group required MCS. The change in (−1.8 ± 2.4 vs. −1.2 ± 2.0, p = 0.12) and at least 2-grade reduction (75 vs. 75%, p = 1.0) in the WHO ordinal scale was also similar between groups.ConclusionPatients hospitalized with COVID-19 and evidence of cardiac injury did not benefit from colchicine therapy.
Significance and Determinants of Plasma Apelin in Patients With Obstructive Hypertrophic Cardiomyopathy
Authors: Yang Chengzhi , Zhang Changlin , Jia Ruofei , Qiao Shubin , Yuan Jiansong , Jin Zening 
Published: June 2022

BackgroundRecent studies suggest apelin has multiple protective effects in some cardiovascular diseases. However, there are few data concerning apelin levels in patients with obstructive hypertrophic cardiomyopathy (OHCM) or the relationship between apelin levels and severity of OHCM.MethodsWe studied 88 patients with OHCM and 32 control subjects with matched age and sex distribution. Complete medical history was collected and related examinations were performed. Cardiac magnetic resonance (CMR) and echocardiography were employed to characterize cardiac morphology and function. Plasma apelin was measured by enzyme-linked immunosorbent assay (ELISA).ResultsPlasma apelin levels were significantly lower in patients with OHCM than those in control subjects (96.6 ± 34.3 vs. 169.4 ± 62.5 μg/L, p &lt; 0.001). When patients with OHCM were divided into two groups according to the mean value of plasma apelin, patients with lower apelin levels (plasma apelin ≤ 96.6 μg/L) had greater septal wall thickness (SWT; 25.6 ± 5.5 vs. 23.2 ± 4.3 mm, p = 0.035) and less right ventricular end-diastolic diameter (RVEDD; 20.4 ± 3.3 vs. 23.0 ± 3.6 mm, p = 0.001). Consistently, plasma apelin levels were inversely correlated with SWT (r = −0.334, p = 0.002) and positively correlated with RVEDD (r = 0.368, p &lt; 0.001). Besides, plasma apelin levels were inversely correlated with Ln (NT-proBNP) (r = −0.307, p = 0.008) and positively correlated with body mass index (BMI; r = 0.287, p = 0.008). On multivariate analysis, the SWT was independently associated with decreasing plasma apelin, while the RVEDD was independently associated with increasing plasma apelin.ConclusionPlasma apelin levels are reduced in patients with OHCM. The apelin levels are inversely related to SWT and positively related to RVEDD.
Renin-Angiotensin-System Inhibitors Are Associated With Lower In-hospital Mortality in COVID-19 Patients Aged 80 and Older
Authors: Spannella Francesco , Giulietti Federico , Di Pentima Chiara , Allevi Massimiliano , Bordoni Valentina , Filipponi Andrea , Falzetti Sara , Garbuglia Caterina , Scorcella Samuele , Giordano Piero , Sarzani Riccardo 
Published: June 2022

BackgroundOlder adults are at higher risk of morbidity and mortality for coronavirus disease 2019 (COVID-19). Renin-angiotensin-system inhibitors (RASi) were found to have a neutral or protective effect against mortality in COVID-19 adult patients.AimsWe investigated whether this association was confirmed also in COVID-19 older patients.MethodsThis is a prospective observational study on 337 hospitalized older adults (aged 80 years and older). We classified the study population according to usage of RASi before and during hospitalization. A propensity score analysis was also performed to confirm the findings.ResultsThe mean age was 87.4 ± 6.1 years. Patients taking RASi at home were 147 (43.6%). During hospitalization, 38 patients (11.3% of the entire study population) discontinued RASi, while 57 patients (16.9% of the entire study population) started RASi. In-hospital mortality was 43.9%. Patients taking RASi during hospitalization (patients who maintained their home RASi therapy + patients who started RASi during hospitalization) had a significantly lower in-hospital mortality than untreated patients [HR 0.48 (95% CI: 0.34–0.67)], even after adjustment for required respiratory support, functional status, albumin, inflammation, and cardiac biomarkers. The analysis of the groups derived from the “propensity score matching” (58 patients in each group) confirmed these results [HR 0.46 (95% CI: 0.23–0.91)].DiscussionDespite the high risk of death in older COVID-19 patients, RASi therapy during hospitalization was associated with a clinically relevant lower in-hospital mortality, likely due to the benefit of RAS modulation on the cardiopulmonary system during the acute phase of the disease.ConclusionOur findings confirm the protective role of RASi even in COVID-19 patients aged 80 years and older.
Alterations of Cardiac Protein Kinases in Cyclic Nucleotide-Dependent Signaling Pathways in Human Ischemic Heart Failure
Authors: Wang Chunguang , Taskinen Juuso H. , Segersvärd Heli , Immonen Katariina , Kosonen Riikka , Tolva Johanna M. , Mäyränpää Mikko I. , Kovanen Petri T. , Olkkonen Vesa M. , Sinisalo Juha , Laine Mika , Tikkanen Ilkka , Lakkisto Päivi 
Published: June 2022

ObjectivesImpaired protein kinase signaling is a hallmark of ischemic heart disease (IHD). Inadequate understanding of the pathological mechanisms limits the development of therapeutic approaches. We aimed to identify the key cardiac kinases and signaling pathways in patients with IHD with an effort to discover potential therapeutic strategies.MethodsCardiac kinase activity in IHD left ventricle (LV) and the related signaling pathways were investigated by kinomics, transcriptomics, proteomics, and integrated multi-omics approach.ResultsProtein kinase A (PKA) and protein kinase G (PKG) ranked on top in the activity shift among the cardiac kinases. In the IHD LVs, PKA activity decreased markedly compared with that of controls (62% reduction, p = 0.0034), whereas PKG activity remained stable, although the amount of PKG protein increased remarkably (65%, p = 0.003). mRNA levels of adenylate cyclases (ADCY 1, 3, 5, 9) and cAMP-hydrolysing phosphodiesterases (PDE4A, PDE4D) decreased significantly, although no statistically significant alterations were observed in that of PKGs (PRKG1 and PRKG2) and guanylate cyclases (GUCYs). The gene expression of natriuretic peptide CNP decreased remarkably, whereas those of BNP, ANP, and neprilysin increased significantly in the IHD LVs. Proteomics analysis revealed a significant reduction in protein levels of “Energy metabolism” and “Muscle contraction” in the patients. Multi-omics integration highlighted intracellular signaling by second messengers as the top enriched Reactome pathway.ConclusionThe deficiency in cAMP/PKA signaling pathway is strongly implicated in the pathogenesis of IHD. Natriuretic peptide CNP could be a potential therapeutic target for the modulation of cGMP/PKG signaling.
Development and Testing of an Interpretational Bias Measure of Dental Anxiety
Authors: Heaton Lisa J. , Leroux Brian G. , Ramsay Douglas S. 
Published: June 2022

ObjectivesWe hypothesized that individuals with dental care-related anxiety and fear would interpret ambiguous dental situations more negatively than non-anxious individuals. The objectives of these studies were to develop and test a Measure of Dental Anxiety Interpretational Bias (MoDAIB).MethodsIn the development phase, participants completing an online survey provided qualitative and quantitative assessments of dental scenarios that could be interpreted in either positive or negative ways. Scenarios producing the greatest difference in visual analog (VAS) scores between individuals with high vs. low dental anxiety as measured by the Modified Dental Anxiety Scale (MDAS) were included in the MoDAIB. In the testing phase, participants completed an online survey including the newly developed MoDAIB and dental anxiety measures.ResultsIn the development phase, participants (N = 355; 65.6% female) high in dental anxiety (MDAS ≥ 19) gave significantly higher (i.e., more negative) VAS scores to all the dental scenarios than did those low in dental anxiety (p's &lt; 0.05). In the testing phase, the MoDAIB was significantly and positively correlated with the MDAS (r = 0.68, p &lt; 0.001), meaning that those who were high in dental anxiety selected negative interpretations of ambiguous dental scenarios significantly more often than did individuals low in dental anxiety (p's &lt; 0.05). The MoDAIB showed good content validity and test-retest reliability.ConclusionsIndividuals high in dental anxiety interpret ambiguous dental situations more negatively than do less anxious individuals. Understanding individuals' interpretational styles may help dental providers avoid miscommunications. Interventions that train dentally anxious patients to consider more positive interpretations may reduce dental anxiety and should be investigated.
Genetic Mechanism of Geothermal Anomaly in the Gaoyang Uplift of the Jizhong Depression
Authors: Miao Qingzhuang , Wang Guiling , Qi Shihua , Xing Linxiao , Xin Hailiang , Zhou Xiaoni 
Published: June 2022

The Gaoyang uplift is rich in geothermal resources, but there are few studies on the regional geothermal genetic mechanism. A large number of geothermal wells fail in position calculation because of a shortage of basis. By using the methods of P-wave velocity structure imaging and magnetotelluric sounding, it draws the following conclusions: 1) The crustal thickness in the Gaoyang uplift area is relatively thin, about 32 km; 2) The cutting depth of the Gaoyang East fault exceeds 28 km and has reached the bottom of the lower crust. It is a large tensile fault that provides a channel for mantle heat flow into the shallow crust; 3) The Gaoyang uplift and its surrounding depressions form a concave-convex base fluctuation mode, which is conducive to the accumulation of heat flow to the uplift; 4) The deep carbonate thermal reservoir in the Gaoyang uplift is overlaid with Cenozoic sand and mudstone strata, with a thickness of more than 3000 m and low thermal conductivity, which is conducive to the preservation of thermal storage heat. Therefore, the shortening of the heat conduction path caused by regional crustal thinning, convective heat conduction of large faults, concave-convex structure, and thick Cenozoic caprock are the reasons why the heat reservoir temperature in the Gaoyang uplift is higher than that around, which provides a theoretical basis for geothermal development and utilization.
Experimental Research and Instrument Design of Seepage Measurement in Rock and Soil Based on Heat Transfer
Authors: Wu Xiushan , Cui Jiamin , Tong Renyuan , Li Qing 
Published: June 2022

Seepage in the underground rock and soil is one of the main causes of geological disasters. Precursor information for geological disasters is provided by accurately measuring the seepage flow in rock and soil, so as to provide disaster warnings in time. This article analyzes the principle of seepage measurement in rock and soil based on heat transfer, deduces the relationship between the flow rate and temperature of the fluid with a seepage sensor, designs and manufactures an entire seepage measurement sensor, and designs a seepage measurement circuit. Finally, a set of portable geotechnical seepage measuring instruments is designed. An experimental platform is designed to realize seepage flow and temperature change experiments with the seepage sensor, it is proved that the sensor can effectively measure the seepage flow for different experimental samples, the measurement range is 0.06–0.160 ml/s. Based on the measured characteristic temperature of the seepage sensor, the calculated seepage flow is obtained, the relative error between the calculated value and the measured value is within 3%.
Sodium Glucose Cotransporter-2 Inhibitor Protects Against Diabetic Neuropathy and Nephropathy in Modestly Controlled Type 2 Diabetes: Follow-Up Study
Authors: Ishibashi Fukashi , Kosaka Aiko , Tavakoli Mitra 
Published: June 2022

AimsThis three-year follow-up study aimed to elucidate whether sodium-glucose cotransporter-2 inhibitors (SGLT2is) have any protection against diabetic neuropathy and nephropathy in patients with type 2 diabetes via reducing variability in glycemia and extraglycemic factors or their averages.MethodsTwo type 2 diabetic cohorts of 40 and 73 patients treated with or without SGLT2i along with 60 control subjects were recruited. Two diabetic cohorts matched for HbA1c levels and oral hypoglycemic agents other than SGLT2is underwent glycemic control with or without SGLT2is more than two years. The urinary albumin to creatinine ratio (ACR), estimated glomerular filtration rate (eGFR) every 3 months and neuropathy outcome measures and mean Z-score of 8 neurophysiological tests were determined at the baseline and endpoint. Glycemic variability, evaluated by the coefficient of variation of monthly measured HbA1c levels and casual postprandial plasma glucose (CPPG), and coefficient of variation and average of extraglycemic parameters in diabetic cohorts were determined.ResultsThe glycemic variability and variability of some extraglycemic factors in SGLT2i cohort were smaller than those in non-SGLT2i cohort. However, only smaller coefficient of variation of HbA1c improved some neuropathy outcome measures, and ameliorated eGFR decline. SGLT2i improved the Z-score of neurophysiological tests. The optimized changes in the blood pressure, HDL-cholesterol and uric acid by SGLT2i led to neurological and renal protection. SGLT2i decreased the prevalence of nephropathy significantly and the prevalence of neuropathy insignificantly.ConclusionOver 3 years period, SGLT2i significantly improved some neuropathy outcome measures, mean Z-score of 8 neurophysiological tests, and attenuated nephropathy in modestly controlled type 2 diabetes by reducing glycemic variability and mean nonglycemic factors of diabetic microvascular complication.
Analysis of Transient Characteristics of Submersible Tubular Pump During Runaway Transition
Authors: Sun Zhuangzhuang , Yu Jie , Tang Fangping , Ge Hengjun , Yuan Haixia 
Published: June 2022

In order to study the transient characteristics of the submersible tubular pump in the process of power failure, the 6DOF model was used to carry out three unsteady numerical values for the whole flow channel of the pump. The results show that the calculation results of the 6DOF model based on the fourth-order multi-point Adams–Moulton formula are in better agreement with the experimental results than the first-order format to predict the impeller motion. When the unit is powered off, the speed and flow of the pump device decrease rapidly with time. At the maximum head 3.41 m, when the unit enters the runaway condition, the speed is about −1.88 times the initial speed and the flow rate is about −1.98 times the initial flow. The axial force and radial force of the impeller increase alternately, and compared with the normal operating condition, the radial force is significantly increased. In the process of the pump device changing from forward flow to reverse flow, the internal flow state of the pump device is relatively chaotic, and there are a large number of vortices in the flow channel, which is easy to cause structural vibration. Before reaching the runaway state, a large number of vortices also appear inside the impeller and guide vane, causing flow blockage, especially when the flow rate is zero. At the same time, the reverse flow impact causes the local pressure on the blade surface to increase, which threatens the stability of the blade structure. The pressure at the impeller inlet, impeller outlet, and guide vane outlet monitoring points is the largest near zero flow, and the smallest during runaway. The main frequency of the pressure pulsation in the pump device is the blade pass frequency (fBRF) and its harmonics (2fBRF, 3fBRF, 5fBRF, etc.), and the pressure pulsation intensity increases with the increase of the impeller speed. The results of this study provide a theoretical reference for the operation of the submersible tubular pump to ensure the safety and stability of the pumping station.