bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell‐Specific Actions of the Prostaglandin E‐Prostanoid Receptor 4 Attenuating Hypertension: A Dominant Role for Kidney Epithelial Cells Compared With Macrophages
Authors: Yang Ting , Song Chengcheng , Ralph Donna L. , Andrews Portia , Sparks Matthew A. , Koller Beverly H. , McDonough Alicia A. , Coffman Thomas M. 
Published: September 2022

Background
A beneficial role for prostanoids in hypertension is suggested by clinical studies showing nonsteroidal anti‐inflammatory drugs, which block the production of all prostanoids, cause sodium retention and exacerbate hypertension. Among prostanoids, prostaglandin E2 and its E‐prostanoid receptor 4 receptor (EP4R) have been implicated in blood pressure control. Our previous study found that conditional deletion of EP4R from all tissues in adult mice exacerbates angiotensin II‐dependent hypertension, suggesting a powerful effect of EP4R to resist blood pressure elevation. We also found that elimination of EP4R from vascular smooth muscle cells did not affect the severity of hypertension, suggesting nonvascular targets of prostaglandin E mediate this antihypertensive effect.

Methods and Results

Here we generated mice with cell‐specific deletion of EP4R from macrophage‐specific EP4 receptor knockouts or kidney epithelial cells (KEKO) to assess the contributions of EP4R in these cells to hypertension pathogenesis. Macrophage‐specific EP4 receptor knockouts showed similar blood pressure responses to alterations in dietary sodium or chronic angiotensin II infusion as Controls. By contrast, angiotensin II‐dependent hypertension was significantly augmented in KEKOs (mean arterial pressure: 146±3 mm Hg) compared with Controls (137±4 mm Hg;
P
=0.02), which was accompanied by impaired natriuresis in KEKOs. Because EP4R expression in the kidney is enriched in the collecting duct, we compared responses to amiloride in angiotensin II‐infused KEKOs and Controls. Blockade of the epithelial sodium channel with amiloride caused exaggerated natriuresis in KEKOs compared with Controls (0.21±0.01 versus 0.15±0.02 mmol/24 hour per 20 g;
P
=0.015).

Conclusions
Our data suggest EP4R in kidney epithelia attenuates hypertension. This antihypertension effect of EP4R may be mediated by reducing the activity of the epithelial sodium channel, thereby promoting natriuresis.
Explaining the Neuroevolution of Fighting Creatures Through Virtual fMRI
Authors: Godin-Dubois Kevin , Cussat-Blanc Sylvain , Duthen Yves 
Published: September 2022

Abstract
While interest in artificial neural networks (ANNs) has been renewed by the ubiquitous use of deep learning to solve high-dimensional problems, we are still far from general artificial intelligence. In this article, we address the problem of emergent cognitive capabilities and, more crucially, of their detection, by relying on co-evolving creatures with mutable morphology and neural structure. The former is implemented via both static and mobile structures whose shapes are controlled by cubic splines. The latter uses ESHyperNEAT to discover not only appropriate combinations of connections and weights but also to extrapolate hidden neuron distribution. The creatures integrate low-level perceptions (touch/pain proprioceptors, retina-based vision, frequency-based hearing) to inform their actions. By discovering a functional mapping between individual neurons and specific stimuli, we extract a high-level module-based abstraction of a creature’s brain. This drastically simplifies the discovery of relationships between naturally occurring events and their neural implementation. Applying this methodology to creatures resulting from solitary and tag-team co-evolution showed remarkable dynamics such as range-finding and structured communication. Such discovery was made possible by the abstraction provided by the modular ANN which allowed groups of neurons to be viewed as functionally enclosed entities.
A transformer model for learning spatiotemporal contextual representation in fMRI data
Authors: Asadi Nima , Olson Ingrid R. , Obradovic Zoran 
Published: September 2022

Abstract
Representation learning is a core component in data-driven modeling of various complex phenomena. Learning a contextually informative representation can especially benefit the analysis of fMRI data because of the complexities and dynamic dependencies present in such datasets. In this work, we propose a framework based on transformer models to learn an embedding of the fMRI data by taking the spatiotemporal contextual information in the data into account. This approach takes the multivariate BOLD time series of the regions of the brain as well as their functional connectivity network simultaneously as the input to create a set of meaningful features that can in turn be used in various downstream tasks such as classification, feature extraction, and statistical analysis. The proposed spatiotemporal framework uses the attention mechanism as well as the graph convolution neural network to jointly inject the contextual information regarding the dynamics in time series data and their connectivity into the representation. We demonstrate the benefits of this framework by applying it to two resting-state fMRI datasets, and provide further discussion on various aspects and advantages of it over a number of other commonly adopted architectures.
Responses of infective juveniles of the soybean cyst nematode (Heterodera glycines) and the root-knot nematodes (Meloidogyne hapla, M. incognita) to amino acids
Authors: Jiang Ye , Huang Minghui , Li Chunjie , Hua Cui , Qin Ruifeng , Chang Doudou , Jiang Dan , Zhao Lei , Wang Xuan , Yu Jinyao , Wang Congli 
Published: September 2022

Summary
Plant-parasitic nematode infective juveniles (J2) use phytochemical signals released into the rhizosphere to locate host roots. Amino acids are the second most abundant metabolites of root exudates, but it is unknown if they are associated with J2 chemotaxis. In this study, J2 chemotaxis and mortality of the soybean cyst nematode (Heterodera glycines) and root-knot nematodes (Meloidogyne incognita and M. hapla) were examined in response to 15 amino acids and the corresponding pH values for tested amino acid solutions were measured. Responses varied by amino acid and among the species. Significant attraction, determined by J2 count within amino acid solution dispensers after 24 h exposure, occurred with 19 out of 45 J2-amino acid combinations. Heterodera glycines, M. hapla and M. incognita were attracted to nine, three and seven amino acids, respectively. Strongest attractions were to acidic polar amino acids aspartate and glutamate (H. glycines, M. hapla) and basic polar arginine (M. hapla), as previously reported, acid and basic pH attracting nematodes, thereby indicating that pH might be one of the attraction factors for these amino acids. All three nematodes exhibited clustering behaviours, such as halo or balling formations, just outside amino acid solution dispensers, with H. glycines, M. hapla and M. incognita responding to four, 12 and two amino acids, respectively. Six of 15 amino acid solutions, representing a range of pH values, caused increased mortality. Certain aspartate and glutamate affected both H. glycines and M. hapla; arginine, aspartate, cysteine, lysine, methionine affected M. incognita; and cysteine caused complete mortality in M. hapla. All the results suggest that amino acids affect nematode attraction and mortality.
Predation drives convergent evolution of the thick and baggy cuticle in nematodes
Authors: Ichiishi Kanata , Ekino Taisuke , Kanzaki Natsumi , Shinya Ryoji 
Published: September 2022

Summary
The nematode cuticle is an important structure that provides protection from abiotic environmental stresses and natural enemies. The cuticle ultrastructure of a Myolaimus species (culture code NKZ384) isolated from Kyoto, Japan, was examined in relation to its avoidance of predation by an aphelenchoidid predator, Seinura caverna. The survivability of Myolaimus sp. co-cultured with the predator was examined and compared with those of four Poikilolaimus spp. previously reported by the present authors. Myolaimus and two of the four Poikilolaimus spp. share a ‘baggy’ cuticle and resisted predation effectively. However, the ultrastructure differed between these two genera: i.e., the cuticle of Myolaimus sp. is seven-zoned, while that of P. regenfussi and P. oxycercus is five-zoned. In addition, Myolaimus sp. does not possess the characteristic osmophilic zone reported in Poikilolaimus spp. Therefore, although the ultrastructure differs, the thick and baggy cuticle found in these two phylogenetically distant genera exhibits functional convergence to resist predation.
Saying ‘I Do’ to Feminism
Authors: Trudeau Elizabeth , Jorgensen Abigail 
Published: September 2022

Abstract
Do Christian women who identify as feminist act differently than those who do not? Scholars have pointed out that religious women may exhibit beliefs about gender equality, whether or not they identify as feminists. But do women who choose to identify explicitly as feminists differ in their behavior from women who do not? We answer this question by analyzing 307 qualitative survey responses from Christian women in the U.S. about an important point in their lives, when gender and religious identities become particularly salient and fraught: weddings. We found that explicit feminists thought and acted differently compared to “implicit” and “non” feminists. Further, Protestant and Catholic feminists used different strategies to intersect their feminist and religious identities. We conclude that the decision to identify explicitly as a feminist or not does not just represent a semantic difference between Christian women but a real difference in both beliefs and actions.
Changes in ENSO Characteristics in Model Simulations with Considerably Altered Background Climate States
Authors: Siuts Thea , Bayr Tobias , Lübbecke Joke F. 
Published: September 2022

Abstract
Changes in the background climate are known to affect El Niño–Southern Oscillation (ENSO) by altering feedbacks that control ENSO’s characteristics. Here, the sensitivity of ENSO variability to the background climate is investigated by utilizing two Community Earth System Model, version 1 (CESM1), simulations in which the solar constant is altered by ±25 W m−2. The resulting stable warm and cold climate mean state simulations differ in terms of ENSO amplitude, frequency, diversity, asymmetry, and seasonality. In the warm run, ENSO reveals a larger amplitude and occurs at higher frequencies relative to the cold and control runs as well as observations. The warm run also features more eastern Pacific El Niños, an increased asymmetry, and a stronger seasonal phase locking. These changes are linked to changes in the mean state via the amplifying and damping feedbacks. In the warm run, a shallower mean thermocline results in a stronger subsurface–surface coupling, whereas the cold run reveals reduced ENSO variability due to a reduced Bjerknes feedback in accordance with a deeper mean thermocline and enhanced surface wind stress. A strong zonal advective and upwelling feedback further contribute to the large ENSO amplitude in the run with a warmer mean state. In the cold run, ENSO events are partly forced by anomalous shortwave radiation. However, in light of the large temperature contrast between the simulations of up to 6 K in the tropical Pacific, the relatively small changes in ENSO variability highlight the robustness of ENSO dynamics under vastly different climate mean states.
Role of a Pacific Easterly Wave in the Genesis of Hagupit (2008)
Authors: Zhao Chen , Li Tim , Bi Mingyu 
Published: September 2022

Abstract
The Advanced version of the Weather Research and Forecasting (WRF-ARW) Model is used to investigate the influence of an easterly wave (EW) on the genesis of Typhoon Hagupit (2008) in the western North Pacific. Observational analysis indicates that the precursor disturbance of Typhoon Hagupit (2008) is an easterly wave (EW) in the western North Pacific, which can be detected at least 7 days prior to the typhoon genesis. In the control experiment, the genesis of the typhoon is well captured. A sensitivity experiment is conducted by filtering out the synoptic-scale (3–8-day) signals associated with the EW. The absence of the EW eliminates the typhoon genesis. Two mechanisms are proposed regarding the effect of the EW on the genesis of Hagupit. First, the background cyclonic vorticity of the EW could induce the small-scale cyclonic vorticities to merge and develop into a system-scale vortex. Second, the EW provides a favorable environment in situ for the rapid development of the typhoon disturbance through a positive moisture–convection feedback.
Short-Term Visibility Prediction Using Tree-Based Machine Learning Algorithms and Numerical Weather Prediction Data
Authors: Kim Bu-Yo , Belorid Miloslav , Cha Joo Wan 
Published: September 2022

Abstract
Accurate visibility prediction is imperative in the interests of human and environmental health. However, the existing numerical models for visibility prediction are characterized by low prediction accuracy and high computational cost. Thus, in this study, we predicted visibility using tree-based machine learning algorithms and numerical weather prediction data determined by the local data assimilation and prediction system (LDAPS) of the Korea Meteorological Administration. We then evaluated the accuracy of visibility prediction for Seoul, South Korea, through a comparative analysis using observed visibility from the automated synoptic observing system. The visibility predicted by machine learning algorithm was compared with the visibility predicted by LDAPS. The LDAPS data employed to construct the visibility prediction model were divided into learning, validation, and test sets. The optimal machine learning algorithm for visibility prediction was determined using the learning and validation sets. In this study, the extreme gradient boosting (XGB) algorithm showed the highest accuracy for visibility prediction. Comparative results using the test sets revealed lower prediction error and higher correlation coefficient for visibility predicted by the XGB algorithm (bias: −0.62 km, MAE: 2.04 km, RMSE: 2.94 km, and R: 0.88) than for that predicted by LDAPS (bias: −0.32 km, MAE: 4.66 km, RMSE: 6.48 km, and R: 0.40). Moreover, the mean equitable threat score (ETS) also indicated higher prediction accuracy for visibility predicted by the XGB algorithm (ETS: 0.5–0.6 for visibility ranges) than for that predicted by LDAPS (ETS: 0.1–0.2).
Increase in Rate of Hospitalizations for Pediatric Intentional Acetaminophen Ingestion at a Single Center During the COVID-19 Pandemic
Authors: Moss Rachel E. , Hertzberg Emily H. , Person Hannibal , Stoffels Guillaume , Zackai Sheemon , Bucuvalas John , Gillen Jennifer K. 
Published: September 2022

Objectives: Social disruption due to COVID-19 has detrimentally affected American adolescents’ emotional well-being. Within our system, pediatric acetaminophen ingestions increased in 2020, compared with previous years. We sought to evaluate the rate of hospitalizations for acetaminophen self-harm ingestions and self-harm of adolescents during the COVID-19 pandemic. Study Design: We identified patients (aged 0-23) from billing data with diagnosis of acetaminophen ingestion with self-harm intent (ICD-10 code T391X2A), from a multicenter urban, quaternary health care system. We performed retrospective chart review from 2016 to 2020 and performed statistics using a generalized estimating equation (GEE) logistic regression model. Results: From 2016 to 2020, there were 25 790 discharges of adolescents with 65 acetaminophen self-harm ingestion and 148 self-harm discharges. Of the 65 acetaminophen patients, 75% identified as female and 54% identified as non-white; 71% with Medicaid insurance. The proportion of acetaminophen ingestion and self-harm admissions increased from 0.13% in 2016 to 0.46% by 2020 and 0.42% in 2016 to 0.73% by 2020, respectively. The odds of acetaminophen ingestion admission increased by 28% each additional year (odds ratio = 1.28; 95% confidence interval: 1.08, 1.53; P = .006). There was not enough evidence to conclude that the log-odds of a self-harm ingestion were linearly related to time ( P = .06). Conclusions: Acetaminophen ingestion for self-harm has significantly increased, while overall self-harm has increased to a lesser, nonsignificant degree. Primarily females of color and those with Medicaid insurance are affected. It is important to note this growing, disturbing trend, and to continue to screen for depression in our adolescent community and ensure access to mental health resources.
Professionalising the police pragmatically
Authors: McCanney John , Taylor Julie C , Morris Karen 
Published: September 2022

The College of Policing has stated its intention to have policing recognised as a profession. In pursuit of this ambition, they have created a Code of Ethics and introduced a graduate entry requirement for new recruits. These changes reflect common features of established professions such as medicine and the law. Another common feature of established professions is an established body of knowledge that informs professional practice. The College has developed a Crime Reduction Toolkit as the genesis of a knowledge base for policing. The evidence presented on the toolkit is generally based on random control trials and their systematic review. While this is accords with the evidence-based approach supported by the College and others it has been criticised as being too quantitative. Some commentators have argued that it overlooks the qualitative approaches such as ethnography which have been the traditional research approach to the study of policing and ignores the voice of practitioners. It is generally accepted that to date research has had little impact on policing practice. This article argues for the adoption of a pragmatic philosophical framework for the development and application of a professional knowledge-based for policing. Pragmatic philosophy would facilitate the incorporation of both qualitative and quantitative research into the creation of a knowledgebase. Furthermore, pragmatism is an action-oriented philosophy that accords with the College of Policing’s ‘what works’ agenda, and would not only accommodate practitioner research but provides a structure for changes to current practices that are needed if the police are to become a profession
The mechanism of radiotherapy for lung adenocarcinoma in promoting protein SIRT6-mediated deacetylation of RBBP8 to enhance the sensitivity of targeted therapy
Authors: Wang Jiying , Sheng Zhaoying , Dong Zhiyi , Wu Qiongya , Cai Yong 
Published: September 2022

Background Lung cancer has the fastest increase in morbidity and mortality, and is one of the most threatening malignant tumors to human health and life. Both radiotherapy and targeted therapy are typical treatments after lung cancer surgery. Radiotherapy is a means of locally killing cancer lesions, and it plays an important role in the entire management of lung cancer. Gefitinib is one of the most commonly used targeted therapy drugs in the treatment of lung cancer. The purpose of this project is to explore the mechanism by which deacetylation of RBBP8 mediated by radiotherapy-promoting protein SIRT6 in lung adenocarcinoma enhances the sensitivity of targeted therapy. Methods In both the cell experiments and the animal experiments, the samples were divided into five groups: Model group, RT group, CT group, RT+CT group, and RT+CT+inhibitor group. The CCK8 method was used to detect the viability of each group of cells. The flow cytometry experiment was used to analyze the apoptotic characteristics of each group of cells. The scratch test was used to detect the migration ability of each group of cells. Transwell invasion test was used to determine the invasion ability of each group of cells. The lung tumor tissues of each group of mice were collected to analyze the tumor size, volume, and metastasis characteristics. The TUNEL experiment was used to detect the apoptosis characteristics of the cells in the lung cancer tissues of each group mice. Immunohistochemistry experiments were used to analyze the distribution and relative expression characteristics of protein SIRT6 in mouse lung cancer tissues. The colorimetric experiments were used to detect the activity of Caspase 3 and Caspase 8 in each group. Western blot method was used to detect the expression of SIRT6, RBBP8, and MYC in each group. Results In each experiment, the results of the experiment have mutually proven consistency, and there is no contradiction. In addition to the Model group, the other 4 groups used different treatment methods. The better the curative effect, the lower the cell viability of cancer cells and the higher the apoptotic ratio. This is reflected in the CCK8 test, flow cytometry analysis, cell scratch test, Transwell cell migration test, and TUNEL detection. At the same time, colorimetric detection and Western blot analysis also analyzed the levels of SIRT6, RBBP8 and other cancer-related proteins in each group at the molecular level, implying the importance of SIRT6 protein in the treatment process. Conclusion Our project has proved that radiotherapy can promote the protein SIRT6 to deacetylate RBBP8 proteins, and ultimately enhance targeted therapy drug sensitivity.
Productive and Unproductive Sectors’ Interactions in Brazil: A Miyazawa Analysis
Authors: Morrone Henrique , Marquetti Adalmir Antonio , Miebach Alessandro Donadio 
Published: September 2022

This article employs Miyazawa’s method to investigate the interaction between productive and unproductive sectors during the 2002–2014 period in Brazil. The results showed a growing dependence of productive on unproductive sectors together with a rise in the unproductive share in the economy, particularly after 2008. Our ﬁndings stressed the relationship between the rising importance of unproductive industries and lower total output growth, as emphasized by the classical-Marxian literature. JEL Classification: B51, C67, P16
Offsetting Game—Framing Environmental Issues in the Design of a Serious Game
Authors: Nygren Nina V. , Kankainen Ville , Brunet Lucas 
Published: September 2022

Background Biodiversity crisis requires researchers to reflect on tools and strategies to engage with different stakeholders. We propose that serious games can be designed to introduce stakeholders to a novel environmental policy tool and to communicate research on environmental issues. Our case is biodiversity offsetting (BDO), a novel policy tool aiming to reconcile nature conservation with other land uses. As any media, games offer certain framings of the issues they communicate about—some aspects are made more salient than others. However, frame analysis has not been widely used to analyze the design choices or the messages communicated by games. We analyze how these framings are designed into a game communicating about environmental issues. Aim To intervene in the emerging public discussion on BDO in Finland, we designed a land use board game and during the design process, played it with public and private stakeholders who would soon encounter and implement biodiversity offsetting policies in Finland. The aim of this article is to describe how our framings of BDO affected the design process and how those framings interacted with the design decisions we made. With our analysis, we want to contribute to the understanding of how framings and design choices interact in game design and how paying attention to framings is especially important for the design of SGs. Method We analyze how our framings of biodiversity offsetting and our design choices interact in game design. Our understanding of biodiversity offsetting guided our game design, but the design choices also contribute to the framing of the issue itself. Results Game design choices strongly frame the topic of the game and thus influence the function of a serious game. Thus, the framings of the topic should be considered carefully during the game design process, especially in the context of serious games.