bluuebunny/crossref_metadata_2025_split huggingface dataset:
A trading strategy with dual-beta estimates
Authors: Chong James 
Published: February 2022

PurposeThe purpose of this paper is to adopt a trading strategy using upside and downside beta estimates.Design/methodology/approachWith daily data from April 30, 1997 to April 30, 2021, the author utilizes the dual-beta model when estimating upside and downside betas, in constructing and rebalancing a portfolio from a buy list of Dow Jones Industrial Average component stocks. Benchmarks include the S&P 500 Total Return index, Invesco S&P 500 Low Volatility ETF (SPLV) and iShares MSCI USA Min Vol Factor ETF (USMV). The dual-beta portfolio performance is assessed by economic cycles and by the Fama-French five-factor model.FindingsThe dual-beta portfolio outperforms the benchmarks for the whole period under study as well as the majority of sub-periods. It is the only strategy with a statistically positive and economically significant risk-adjusted return.Originality/valueThe author offers a simple stock trading strategy for generating wealth.
The effect of annual reports tone complexity on firms' dividend policy: evidence from the United States
Authors: Satt Harit , Iatridis George 
Published: February 2022

PurposeThis paper investigates the impact of annual reports complexity (associated with tone complexity) on dividend policy and value of dividend policy.Design/methodology/approachThis paper uses the variable complexity provided by the textual analytics software (Diction 7.0) as the proxy for annual reports' tone complexity. The data covered non-financial American firms from years 2011–2019. The pooled ordinary least squares (OLS) regression and the instrumental variable regression are used to test the study’s arguments.FindingsThe findings suggest that the signaling theory of dividends holds in the United States. Firms with more complex annual reports tend to distribute more dividends, mainly in environment of high information. When information asymmetry is high, managers would use dividends as a tool to mitigate information asymmetry. Furthermore, the findings suggest that dividend policy has a stronger impact on firm value, especially when the tones of annual reports are highly complex. These findings support the previous results, namely, that managers would opt for dividend policy as a signaling tool for its positive impact on firm value. The results are robust to potential endogeneity issues and alternative proxies for both dividend policy and information asymmetry.Practical implicationsThe results demonstrate that the dividends' signaling theory holds in the United States, where the findings cannot be generalized to all markets; However, the findings of this research can be of use to potential and current investors, users of annual reports and decision makers as well.Originality/valueThe paper highlights the effect of the tone complexity of annual reports (using 10K text analytics) on the value of dividend policy and dividend policy itself in a developed economy. Understanding this relation will enable stakeholders to forecast future dividends, choose more appropriate valuation methods and hence restore investors' faith.
Tech adoption enables productivity – but it’s more than just an IT issue
Authors: Eichler Felix 
Published: February 2022

Purpose
This paper aims to explore the issue of digital adoption within a business and its impact on employees and to argue that digital adoption is as much a challenge for Human Resources (HR) as it is for Information Technology (IT).

Design/methodology/approach
This paper is based on Felix Eichler’s experience as the co-founder and CTO of Userlane, a business that has helped hundreds of organisations accelerate their digital transformation efforts by improving software adoption amongst employees.

Findings
Technology adoption in a business is as much an HR issue as it is an IT one. This is because is many cases, use of technology is closely linked to productivity and overall employee satisfaction. Businesses can overcome slow adoption by implementing an embedded, inclusive and practical approach to software training.

Originality/value
This paper sheds light on the often overlooked issue of digital adoption and supports the emerging viewpoint that HR teams need to be more actively involved in supporting technology transformation within a business.
Wsp system oppositely modulates antibacterial activity and biofilm formation via FleQ‐FleN complex in Pseudomonas putida
Authors: Nie Hailing , Xiao Yujie , Song Miaomiao , Wu Nianqi , Peng Qi , Duan Wei , Chen Wenli , Huang Qiaoyun 
Published: February 2022

SummaryType VI secretion systems (T6SS) are specific antibacterial weapons employed by diverse bacteria to protect themselves from competitors. Pseudomonas putida KT2440 possesses a functional T6SS (K1‐T6SS) and exhibits antibacterial activity towards a broad range of bacteria. Here we found that the Wsp signal transduction system regulated K1‐T6SS expression via synthesizing the second messenger cyclic di‐GMP (c‐di‐GMP), thus mediating antibacterial activity in P. putida. High‐level c‐di‐GMP produced by Wsp system repressed the transcription of K1‐T6SS genes in structural operon and vgrG1 operon. Transcriptional regulator FleQ and ATPase FleN functioned as repressors in the Wsp system‐modulated K1‐T6SS transcription. However, FleQ and FleN functioned as activators in biofilm formation, and Wsp system promoted biofilm formation largely in a FleQ/FleN‐dependent manner. Furthermore, FleQ‐FleN complex bound directly to the promoter of K1‐T6SS structural operon in vitro, and c‐di‐GMP promoted the binding. Besides, P. putida biofilm cells showed higher c‐di‐GMP levels and lower antibacterial activity than planktonic cells. Overall, our findings reveal a mechanism by which Wsp system oppositely modulates antibacterial activity and biofilm formation via FleQ‐FleN, and demonstrate the relationship between plankton/biofilm lifestyles and antibacterial activity in P. putida.
Methods used for extraction of plant volatiles have potential to preserve truffle aroma: A review
Authors: Phong Win Nee , Gibberd Mark R. , Payne Alan D. , Dykes Gary A. , Coorey Ranil 
Published: February 2022

AbstractTruffles are considered one of the world's most highly prized foods mainly due to their desirable organoleptic properties and rarity. However, truffles are seasonal (harvested mostly in winter from June to August in the Southern Hemisphere and from December to February in the Northern Hemisphere) and extremely perishable. Truffles deteriorate rapidly showing undesirable changes within 10 days from harvest in aroma and visual appearance after harvest. The very short postharvest shelf life (about 7–10 days) limits the potential for export and domestic consumption all year round. Several preservation methods have been studied to prolong their shelf life without the loss of aroma. However, all traditional preservation techniques have their own shortcomings and remain challenging. The extraction of natural truffle aroma volatiles for food applications could be a potential alternative to replace the existing synthetic flavoring used for processed truffle products. Four commonly used extraction methods for recovering volatile compounds from plants, namely, supercritical carbon dioxide extraction, Soxhlet extraction, distillation, and cold pressing, are critically analyzed. Up to date, existing research about the extraction of aroma volatiles from truffles is limited in the literature but based on the volatility of the key truffle volatile compounds, supercritical carbon dioxide extraction may offer the best possibility so that a natural truffle‐based product that can be used in food applications throughout the year can be made available.
Should open repair be the choice in ruptured abdominal aortic aneurysm instead of endovascular aortic repair—Experience in a tertiary referral vascular centre
Authors: Lee Kin‐yan , Li Charis Cho‐ying , Cheng Mina 
Published: February 2022

AbstractAimRuptured abdominal aortic aneurysm (RAAA) is one of the most difficult surgical emergencies with poor outcomes. Aortic occlusion balloon (AOB) can reduce intraoperative mortality and a protocol was made to ensure smooth logistics, which we regard as Protocol II. We herein review the clinical outcomes between endovascular aortic repair (EVAR) and open repair of RAAA.Patients and MethodsWe conducted a retrospective cohort study of 113 patients with RAAA in 10 years. We measured the primary outcome between two cohorts, EVAR and open repair. Furthermore, we looked into the mortality based on subgroup analysis according to treatment modality and the Queen Elizabeth Hospital physiological classification.ResultsThe overall mortality in Protocol II was significantly lower than that in Protocol I. In the open repair group, the 30‐day mortality was lower in Protocol II, especially in Classes IIb, IIC and III. Protocol II also demonstrated better perioperative outcomes. There was lower 30‐day mortality in EVAR than that in open repair in Protocol I but there was no difference between open repair and EVAR in Protocol II.ConclusionProtocol‐driven management with AOB involving a multidisciplinary team approach can improve survival and perioperative outcomes in RAAA. In those cases with unfavourable anatomy, open repair should be performed. For those class IIA RAAAs, the method of repair should depend on the anatomy, and whether to use AOB should be an individualised decision. In cases of class IIB RAAAs, routine use of AOB can improve survival. For classes IIC and III, we would offer open repair with mandatory use of AOB employing a damage control approach.
Sisters of the Earth: The Landscapes, Radical Identities and Performances of Female Reformers in 1819
Authors: Kitchener Caitlin 
Published: February 2022

AbstractFemale reformers were radical activists during 1819. They attempted to forge a ‘feminine’ radicalism through connecting their politics to their domesticity and families. They organised meetings, processed to mass platform protests, crafted liberty caps and wrote letters. Commentators and observers satirised and insulted their efforts through print and press, producing a reading which considered the women to be unfeminine. This conflict between insiders and outsiders creates a ‘female masculinity’ and fragmented identities. Using an historical archaeology framework, this paper analyses the contested identities female reformers performed within radical landscapes and spaces.
Profils d’un lectorat: Enquête sur les signatures d’énigmes du Mercure de France (1724‐1778)
Authors: Léchot Timothée 
Published: February 2022

AbstractLittle is known about the distribution of ancien régime French periodicals and there are few sources on readers’ geographical origins and social positions. Most studies rely on subscriber lists, but subscription is not the only possible mode of acquisition. With a periodical such as Mercure de France (1724‐1778), however, another approach can be used to determine the identity of the public: much of the editorial content is provided by the readers. This article investigates the authors of the enigmas in verse published every month that together constitute a homogeneous corpus of texts. A new reader figure emerges next to the subscriber: that of the reader‐contributor who supplies the periodical with poems. With a more diversified social profile than the subscriber, this reader is often a provincial man who performs a judicial, administrative, ecclesiastical, or military function, and sometimes a woman, a student, a merchant, an artist, or even a prisoner.1
Fishing for DNA? Designing baits for population genetics in target enrichment experiments: Guidelines, considerations and the new tool supeRbaits
Authors: Jiménez‐Mena Belén , Flávio Hugo , Henriques Romina , Manuzzi Alice , Ramos Miguel , Meldrup Dorte , Edson Janette , Pálsson Snæbjörn , Ásta Ólafsdóttir Guðbjörg , Ovenden Jennifer R. , Nielsen Einar Eg 
Published: February 2022

AbstractTargeted sequencing is an increasingly popular next‐generation sequencing (NGS) approach for studying populations that involves focusing sequencing efforts on specific parts of the genome of a species of interest. Methodologies and tools for designing targeted baits are scarce but in high demand. Here, we present specific guidelines and considerations for designing capture sequencing experiments for population genetics for both neutral genomic regions and regions subject to selection. We describe the bait design process for three diverse fish species: Atlantic salmon, Atlantic cod and tiger shark, which was carried out in our research group, and provide an evaluation of the performance of our approach across both historical and modern samples. The workflow used for designing these three bait sets has been implemented in the R‐package supeRbaits, which encompasses our considerations and guidelines for bait design for the benefit of researchers and practitioners. The supeRbaits R‐package is user‐friendly and versatile. It is written in C++ and implemented in R. supeRbaits and its manual are available from Github: https://github.com/BelenJM/supeRbaits
Upregulation of ADAMDEC1 correlates with tumor progression and predicts poor prognosis in non‐small cell lung cancer (NSCLC) via the PI3K/AKT pathway
Authors: Zhu Weiliang , Shi Lin , Gong Yuxin , Zhuo Lin , Wang Siyun , Chen Shaobing , Zhang Bei , Ke Bin 
Published: February 2022

AbstractBackgroundADAM‐like decysin‐1 (ADAMDEC1) has been reported to play an important role in the pathogenesis of multiple diseases, including cancers. However, its biological role in non‐small cell lung cancer (NSCLC) remains largely unknown. Here, we aimed to investigate the biological functions and potential mechanism of ADAMDEC1 in NSCLC.MethodsWe verified ADAMDEC1 as a DEG by a comprehensive strategy of TCGA and GEO datasets miming and computational biology. Relative levels of ADAMDEC1 in NSCLC tissues and the adjacent peritumoral tissues were identified by qRT‐PCR, WB and IHC staining. The biological function of ADAMDEC1 was determined by CCK8, EdU, colony formation assay, apoptosis, wound healing migration and transwell invasion assays. Then, an in vivo tumor formation assay was conducted to explore the effects of ADAMDEC1 on tumor growth.ResultsThe mRNA and protein expression levels of ADAMDEC1 were upregulated in NSCLC tissues and cell lines. ADAMDEC1 expression was associated with clinicopathological characteristics and overall survival of patients with NSCLC. Knockdown of ADAMDEC1 could decrease proliferation and colony forming ability of NSCLC cells, and promoted cell apoptosis, whereas ADAMDEC11 overexpression has opposite effects in NSCLC cells both in vivo and in vitro. Furthermore, we identified ADAMDEC1 accelerates NSCLC progression via activation of the PI3K/ AKT pathway.ConclusionWe verified that ADAMDEC1 promotes the progression of NSCLC via the PI3K/AKT pathway. These findings showed the potential of ADAMDEC1 to be used for therapeutic approaches in NSCLC.
Something fishy in seafood trade? The relation between tariff and non‐tariff barriers
Authors: Baylis Kathy , Nogueira Lia , Fan Linlin , Pace Kathryn 
Published: February 2022

AbstractAs importing countries honor trade agreements to lower tariff rates, traditional tariff barriers may be replaced with non‐tariff barriers. Previous literature has found that the implementation of food safety standards, specifically the use of import notifications and rejections, has acted as a significant barrier to trade in both the EU and the US. This article estimates the relation between a change in tariff rates and the use of non‐tariff barriers, measured by a count of EU seafood import notifications. We find that when trade agreements generate a decrease in tariffs, we observe an increase in the number of import notifications, holding trade volume constant. This effect is strongest for those products that are rejected at the border for less threatening health reasons. Although we see clear evidence that non‐tariff barriers are responding to health risks, they also appear to be correlated with demand for protection.
Microsurgical anastomosis using anterior versus posterior tibial artery in lower limb free tissue transfer
Authors: Theile Harrison , Wiper Jonathan , Noblet Timothy , Watson Luke , Wagels Michael 
Published: February 2022

AbstractBackgroundSoft tissue lower limb reconstruction often requires free tissue transfer. We investigated whether the target vessels used for micro‐vascular anastomosis in the lower limb influences microsurgical outcomes.MethodsData from Plastic Surgery Departments of a major tertiary hospital in the United Kingdom (Leeds General Infirmary, LGI) and Australia (Princess Alexandra Hospital, PAH) were retrospectively analysed. Patients who underwent lower limb free flap reconstruction using the posterior (PTA) or anterior tibial artery (ATA) were included. Patient demographics, free flap and microvascular anastomosis details were analysed. Primary outcome was flap failure. Secondary outcome was return to theatre.ResultsTwo hundred and thirty‐four free flaps were included (PAH 115; LGI 119). 60% were muscle flaps. Eighty‐one percent of patients were male, with trauma the cause in 82%. PTA was used for microsurgical anastomosis in 70% of cases. Venae comitantes were preferred (96%) for venous anastomosis. PTA group showed a higher proportion of patients with trauma as the mechanism of injury. ATA group was more likely to have an end‐to‐end arterial anastomosis configuration. Total flap loss was 3.8%. There was no clinically significant difference in flap failure or return to theatre using ATA versus PTA.ConclusionsIncidence of lower limb free flap failure is low (<5%) and not influenced by use of ATA versus PTA for microsurgical anastomosis. The choice of target vessels for microsurgical reconstruction of the lower limb should be predicated upon factors other than aversion to one or another vessel. If all other microsurgical considerations are equal, the surgeon can exercise personal preference.
Optimizing transfusion therapy for survivors of Haemoglobin Bart's hydrops fetalis syndrome: Defining the targets for haemoglobin‐H fraction and “functional” haemoglobin level
Authors: Amid Ali , Barrowman Nick , Odame Isaac , Kirby‐Allen Melanie 
Published: February 2022

SummaryOwing to the unique pathophysiology of anaemia in haemoglobin Bart's hydrops fetalis (HBHF), a transfusion strategy based on beta‐thalassemia guidelines is suboptimal for chronically transfused HBHF patients. A more aggressive transfusion aimed at reducing the proportion of non‐functional HbH and improving the “functional” haemoglobin (f‐Hb) can lead to reduced haemolysis and improved tissue oxygenation. However, the optimal transfusion targets for these parameters are not yet defined. In this retrospective, longitudinal study on four chronically transfused patients with HBHF, we used receiver operating characteristic curves to find a pre‐transfusion f‐Hb of 106 g/l and a HbH of 16.1% to be the optimal thresholds to achieve a normal soluble transferrin receptor and lactate dehydrogenase, respectively.
Adults with immune thrombocytopenia who switched to avatrombopag following prior treatment with eltrombopag or romiplostim: A multicentre US study
Authors: Al‐Samkari Hanny , Jiang Debbie , Gernsheimer Terry , Liebman Howard , Lee Susie , Wojdyla Matthew , Vredenburg Michael , Cuker Adam 
Published: February 2022

SummaryPatients with immune thrombocytopenia (ITP) may respond to one thrombopoietin receptor agonist (TPO‐RA) but not another. Limited data are available describing outcomes in patients who switched from romiplostim or eltrombopag to avatrombopag, a newer oral TPO‐RA. We performed a retrospective observational study of adults with ITP who switched from eltrombopag or romiplostim to avatrombopag at four US tertiary ITP referral centres. Forty‐four patients were included, with a mean ITP duration of 8.3 years and a median (range) of four prior ITP treatments. On avatrombopag, 41/44 patients (93%) achieved a platelet response (≥50 × 109/l) and 38/44 patients (86%) achieved a complete response (≥100 × 109/l). In all patients, the median platelet count on eltrombopag or romiplostim was 45 × 109/l vs 114 × 109/l on avatrombopag (p < 0.0001); in patients switched for ineffectiveness of romiplostim/eltrombopag, it was 28 × 109/l on romiplostim/eltrombopag vs 88 × 109/l on avatrombopag (p = 0.025). Fifty‐seven percent of patients receiving concomitant ITP medications before switching discontinued them after switching, including 63% of patients receiving chronic corticosteroids. In a heavily pretreated chronic ITP population, avatrombopag was effective following therapy with romiplostim or eltrombopag, with high response rates even in patients with inadequate response to a prior TPO‐RA.
Authority, conformity and obedience: Applying Friedrich’s theory of authority to the classics
Authors: Spillane Robert , Joullié Jean‐Etienne 
Published: February 2022

AbstractIn the conformity and obedience studies of Asch and Milgram, legitimate authority is defined as a form of power to which subjects submit irrationally. This view assumes a causative process which the subjects’ behaviour is said to manifest. Furthermore, this view assumes that there is illegitimate (or malevolent) authority. Carl J. Friedrich's theory of authority as reasoned elaboration offers an alternative perspective, which reveals conceptual differences between authority and such related constructs as power and legitimacy. When these concepts are properly distinguished, a re‐interpretation of the classical studies of conformity and obedience is called forth. Such an exercise produces insights into some of the discipline's most controversial, if not disturbing, results. Specifically, it leads to an understanding of laboratory conformity and obedience in rational terms.
DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting PERP expression
Authors: Shan Bao‐Qian , Wang Xiao‐Min , Zheng Li , Han Yao , Gao Jie , Lv Meng‐Dan , Zhang Yi , Liu Yi‐Xuan , Zhang Han , Chen Hao‐Sa , Ao Lei , Zhang Yin‐Li , Lu Xiang , Wu Zhong‐Jie , Xu Ying , Che Xuan , Heger Michal , Cheng Shu‐Qun , Pan Wei‐Wei , Zhang Xin 
Published: February 2022

AbstractEvolutionarily conserved DDB1‐and CUL4‐associated factor 13 (DCAF13) is a recently discovered substrate receptor for the cullin RING‐finger ubiquitin ligase 4 (CRL4) E3 ubiquitin ligase that regulates cell cycle progression. DCAF13 is overexpressed in many cancers, although its role in breast cancer is currently elusive. In this study we demonstrate that DCAF13 is overexpressed in human breast cancer and that its overexpression closely correlates with poor prognosis, suggesting that DCAF13 may serve as a diagnostic marker and therapeutic target. We knocked down DCAF13 in breast cancer cell lines using CRISPR/Cas9 and found that DCAF13 deletion markedly reduced breast cancer cell proliferation, clone formation, and migration both in vitro and in vivo. In addition, DCAF13 deletion promoted breast cancer cell apoptosis and senescence, and induced cell cycle arrest in the G1/S phase. Genome‐wide RNAseq analysis and western blotting revealed that loss of DCAF13 resulted in both mRNA and protein accumulation of p53 apoptosis effector related to PMP22 (PERP). Knockdown of PERP partially reversed the hampered cell proliferation induced by DCAF13 knockdown. Co‐immunoprecipitation assays revealed that DCAF13 and DNA damage‐binding protein 1 (DDB1) directly interact with PERP. Overexpression of DDB1 significantly increased PERP polyubiquitination, suggesting that CRL4DCAF13 E3 ligase targets PERP for ubiquitination and proteasomal degradation. In conclusion, DCAF13 and the downstream effector PERP occupy key roles in breast cancer proliferation and potentially serve as prognostics and therapeutic targets.