bluuebunny/crossref_metadata_2025_split huggingface dataset:
Derivative-free trust region optimization for robust well control under geological uncertainty
Authors: Silva Thiago L. , Bellout Mathias C. , Giuliani Caio , Camponogara Eduardo , Pavlov Alexey 
Published: February 2022

AbstractA Derivative-Free Trust-Region (DFTR) algorithm is proposed to solve the robust well control optimization problem under geological uncertainty. Derivative-Free (DF) methods are often a practical alternative when gradients are not available or are unreliable due to cost function discontinuities, e.g., caused by enforcement of simulation-based constraints. However, the effectiveness of DF methods for solving realistic cases is heavily dependent on an efficient sampling strategy since cost function calculations often involve time-consuming reservoir simulations. The DFTR algorithm samples the cost function space around an incumbent solution and builds a quadratic polynomial model, valid within a bounded region (the trust-region). A minimization of the quadratic model guides the method in its search for descent. Because of the curvature information provided by the model-based routine, the trust-region approach is able to conduct a more efficient search compared to other sampling methods, e.g., direct-search approaches. DFTR is implemented within FieldOpt, an open-source framework for field development optimization, and is tested in the Olympus benchmark against two other types of methods commonly applied to production optimization: a direct-search (Asynchronous Parallel Pattern Search) and a population-based (Particle Swarm Optimization). Current results show that DFTR has improved performance compared to the model-free approaches. In particular, the method presented improved convergence, being capable to reach solutions with higher NPV requiring comparatively fewer iterations. This feature can be particularly attractive for practitioners who seek ways to improve production strategies while using an ensemble of full-fledged models, where good convergence properties are even more relevant.
Risk management in green building: a review of the current state of research and future directions
Authors: Nguyen Hung Duy , Macchion Laura 
Published: February 2022

AbstractThere has been considerable interest in investigating risk factors in Green Building (GB) projects, with increasing debates in recent years. This study aims to investigate tendencies and identify gaps in the GB risk literature, which can define future research guidelines, with an extensive analysis of the latest contributions. A systematic literature review was conducted by analyzing 64 relevant studies from 2006 to 2020. The results revealed that the GB risk topic is somewhat nascent but growing and almost limited to several countries, including Singapore, the USA, Australia, and China. Notably, this research discovered and classified the main themes of GB risk studies: (1) identify risk factors in implementing GB projects, (2) create risk assessment models for GB projects, (3) study according to specific types of GB risks, and (4) investigate risks in green retrofit projects. Also, a comprehensive list of GB risk factors was provided that could be a helpful reference for industry practitioners and future researchers. Furthermore, this research identified gaps in the current literature, such as inconsistency in identifying GB risk factors, lack of investigation of the relationship between GB risks and project outcomes, and lack of exploring in cross-country or developing countries. Finally, this research suggested future research directions to enrich the literature. Thus, this study contributes a valuable platform for both practitioners and researchers to comprehend the development of the GB risk literature.
Social Participation of German Students with and without a Migration Background
Authors: Hamel Niklas , Schwab Susanne , Wahl Sebastian 
Published: February 2022

AbstractSocial participation is an important factor for students’ socio-emotional/academic development. The literature on the topic discusses four domains in this regard: friendships, interactions, social acceptance, and self-perception of social inclusion. It shows that marginalized groups (e.g., students with behavioral problems/learning deficiencies/physical disabilities) are experience difficulties in those domains. Little, however, is known about the effect of a migration background (one of the most commonly marginalized groups) in this context. Therefore, self-ratings and peer ratings of 818 fourth graders (148 with a migration background, defined by their first learned language not being German) were assessed. The results of the ANOVA indicate that students with a migration background show a decreased level of friendships, interactions, and social acceptance. Gender effects on self-perceived social inclusion were also found. This suggests that social participation is a rather complex concept, which is also impaired for marginalized groups due to social factors like a migration background.
Effectiveness of preoxygenation by conventional face mask versus non-invasive ventilation in morbidly obese patients: measurable by the oxygen-reserve index?
Authors: Bathe Janina , Malik Sadia , Pinnschmidt Hans O. , Zitzmann Amelie , Behem Christoph R. , Trepte Constantin C. , Reuter Daniel A. 
Published: February 2022

AbstractPreoxygenation is a crucial manoeuvre for patients’ safety, particularly for morbidly obese patients due to their reduced pulmonary reserve and increased risk for difficult airway situations. The oxygen reserve index (ORI™) was recently introduced as a new parameter of multiple wavelength pulse oximetry and has been advocated to allow assessment of hyperoxia [quantified by the resulting arterial oxygen partial pressure (PaO2)]. This study investigates if ORI can be used to evaluate the impact of two different preoxygenation manoeuvres on the grade of hyperoxia. Two preoxygenation manoeuvres were sequentially evaluated in 41 morbidly obese patients: First, breathing 100% oxygen for 5 min via standard face mask. Second, after achieving a second baseline, 5 min of non-invasive ventilation (NIV) with 100% oxygen. The effect of preoxygenation on ORI compared to PaO2 was evaluated and whether differences in the two preoxygenation manoeuvres can be monitored by ORI. Overall correlation of PaO2 and ORI was significant (Spearman-Rho coefficient of correlation 0.818, p < 0.001). However, ORI could not differentiate between the two preoxygenation manoeuvres although the PaO2 values for NIV preoxygenation were significantly higher compared to standard preoxygenation (median 505 mmHg (M1) vs. 550 mmHg (M3); p < 0.0001). In contrast, ORI values did not differ significantly (median 0.39 (M1) vs. 0.38 (M3); p = 0.758). Absolute values of ORI cannot be used to assess effectiveness of a preoxygenation procedure in bariatric patients, mainly because its range of discrimination is considerably lower than the high ranges of PaO2 attained by adequate preoxygenation. Trial registration German Clinical Trials Register: DRKS00025023 (retrospectively registered on April 16th, 2021).
Integrated multiple analytes and semi-mechanistic population pharmacokinetic model of tusamitamab ravtansine, a DM4 anti-CEACAM5 antibody-drug conjugate
Authors: Pouzin Clemence , Gibiansky Leonid , Fagniez Nathalie , Chadjaa Mustapha , Tod Michel , Nguyen Laurent 
Published: February 2022

AbstractTusamitamab ravtansine (SAR408701) is an antibody-drug conjugate (ADC), combining a humanized monoclonal antibody (IgG1) targeting carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) and a potent cytotoxic maytansinoid derivative, DM4, inhibiting microtubule assembly. SAR408701 is currently in clinical development for the treatment of advanced solid tumors expressing CEACAM5. It is administered intravenously as a conjugated antibody with an average Drug Antibody Ratio (DAR) of 3.8. During SAR408701 clinical development, four entities were measured in plasma: conjugated antibody (SAR408701), naked antibody (NAB), DM4 and its methylated metabolite (MeDM4), both being active. Average DAR and proportions of individual DAR species were also assessed in a subset of patients. An integrated and semi-mechanistic population pharmacokinetic model describing the time-course of all entities in plasma and DAR measurements has been developed. All DAR moieties were assumed to share the same drug disposition parameters, excepted for clearance which differed for DAR0 (i.e. NAB entity). The conversion of higher DAR to lower DAR resulted in a DAR-dependent ADC deconjugation and was represented as an irreversible first-order process. Each conjugated antibody was assumed to contribute to DM4 formation. All data were fitted simultaneously and the model developed was successful in describing the pharmacokinetic profile of each entity. Such a structural model could be translated to other ADCs and gives insight of mechanistic processes governing ADC disposition. This framework will further be expanded to evaluate covariates impact on SAR408701 pharmacokinetics and its derivatives, and thus can help identifying sources of pharmacokinetic variability and potential efficacy and safety pharmacokinetic drivers.
A mixed-integer programming approach for solving university course timetabling problems
Authors: Rappos Efstratios , Thiémard Eric , Robert Stephan , Hêche Jean-François 
Published: February 2022

AbstractThis article presents a mixed-integer programming model for solving the university timetabling problem which considers the allocation of students to classes and the assignment of rooms and time periods to each class. The model was developed as part of our participation in the International Timetabling Competition 2019 and produced a ranking of second place at the competition. Modeling a timetabling problem as a mixed-integer program is not new. Our contribution rests on a number of innovative features adapted to this problem which allow for a reduction in the number of variables and constraints of the mixed-integer program to manageable levels achieving a reasonable computational performance. The proposed algorithm consists of a first-stage method to obtain an initial feasible solution and a second-stage local search procedure to iteratively improve the solution value, both of which involve the optimization of mixed-integer programming problems.
Characterization of the wave phenomenon of flash-induced chlorophyll fluorescence in Chlamydomonas reinhardtii
Authors: Patil Priyanka Pradeep , Mohammad Aslam Sabit , Vass Imre , Szabó Milán 
Published: February 2022

AbstractFlash-induced chlorophyll fluorescence relaxation is a powerful tool to monitor the reoxidation reactions of the reduced primary quinone acceptor, QA− by QB and the plastoquinone (PQ) pool, as well as the charge recombination reactions between the donor and acceptor side components of Photosystem II (PSII). Under certain conditions, when the PQ pool is highly reduced (e.g. in microaerobic conditions), a wave phenomenon appears in the fluorescence relaxation kinetics, which reflects the transient reoxidation and re-reduction of QA− by various electron transfer processes, which in cyanobacteria is mediated by NAD(P)H dehydrogenase (NDH-1). The wave phenomenon was also observed and assigned to the operation of type 2 NAD(P)H dehydrogenase (NDH-2) in the green alga Chlamydomonas reinhardtii under hydrogen-producing conditions, which required a long incubation of algae under sulphur deprivation (Krishna et al. J Exp Bot 70 (21):6321–6336, 2019). However, the conditions that induce the wave remained largely uncharacterized so far in microalgae. In this work, we investigated the wave phenomenon in Chlamydomonas reinhardtii under conditions that lead to a decrease of PSII activity by applying hydroxylamine treatment, which impacts the donor side of PSII in combination with a strongly reducing environment of the PQ pool (microaerobic conditions). A similar wave phenomenon could be induced by photoinhibitory conditions (illumination with strong light in the presence of the protein synthesis inhibitor lincomycin). These results indicate that the fluorescence wave phenomenon is activated in green algae when the PSII activity decreases relative to Photosystem I (PS I) activity and the PQ pool is strongly reduced. Therefore, the fluorescence wave could be used as a sensitive indicator of altered intersystem electron transfer processes, e.g. under stress conditions.
Combination of a Serious Game Application and Direct Contact with Mental Health Patients
Authors: Cangas Adolfo J. , Sánchez-Lozano Irene , Aguilar-Parra José M. , Trigueros Ruben 
Published: February 2022

AbstractCurrently, one of the difficulties associated with patient recovery from severe mental disorders is stigma. Some authors have even identified its effects as a “second illness.” In order to combat these difficulties, various stigma awareness programs have been launched. Furthermore, in recent years, new technologies have also been incorporated, such as in the cases of serious games (educational video games) designed for this purpose. The present study examines the combined effect of a serious game called Stigma-Stop with a stigma awareness program based on direct contact between students and mental health patients. A total of 313 students participated in the study. The individuals were divided into two experimental groups (one which utilized Stigma-Stop and another which did not) and a control group. The results demonstrated that the two interventions were effective in reducing stigma, but the group which featured the serious game obtained a greater improvement on the fear factor. The discussion section addresses the relevance of these results.
Wie verändert sich die Unterrichts- und Schulqualität, die Leistung und die Schülerzusammensetzung nach der Schulinspektionsdiagnose „erheblicher Entwicklungsbedarf“?
Authors: Wenger Marina , Gärtner Holger , Brunner Martin 
Published: February 2022

ZusammenfassungDie Schulinspektion evaluiert Schulen mit dem Ziel der Qualitätssicherung von Unterrichts- und Schulqualität. Dies gilt insbesondere für Schulen, an denen „erheblicher Entwicklungsbedarf“ festgestellt wurde. Diese Schulen bekommen zusätzliche Unterstützung, erfahren aber auch zusätzlichen Druck durch diese Einordnung. Die weitere Entwicklung dieser Schulen ist bisher kaum erforscht. Diese Studie untersucht mit Daten der Schulinspektion, der amtlichen Statistik und Leistungsdaten von 333 Berliner Grundschulen Veränderungen in Indikatoren der Unterrichts- und Schulqualität, der Schulleistung, und der Zusammensetzung der Schülerschaft (SES und Anteil mit nicht-deutscher Herkunftssprache) nach der Diagnose „erheblicher Entwicklungsbedarf“. Die empirischen Analysen zeigten, dass sich bei diesen Schulen die Unterrichts- und Schulqualität nur geringfügig veränderte, sich der Leistungsabstand zu allen anderen Grundschulen nicht statistisch signifikant verringerte, und sich die Zusammensetzung der Schülerschaft hinsichtlich des sozioökonomischen Status (SES) nicht veränderte. Jedoch erhöhte sich der Anteil von Kindern mit nicht-deutscher Herkunftssprache statistisch signifikant.
Computational Techniques Based on Artificial Intelligence for Extracting Optimal Parameters of PEMFCs: Survey and Insights
Authors: Ashraf Hossam , Abdellatif Sameh O. , Elkholy Mahmoud M. , El‑Fergany Attia A. 
Published: February 2022

AbstractFor the sake of precise simulation, and proper controlling of the performance of the proton exchange membrane fuel cells (PEMFCs) generating systems, robust and neat mathematical modelling is crucially needed. Principally, the robustness and precision of modelling strategy depend on the accurate identification of PEMFC’s uncertain parameters. Hence, in the last decade, with the noteworthy computational development, plenty of meta-heuristic algorithms (MHAs) are applied to tackle such problem, which have attained very positive results. Thus, this review paper aims at announcing novel inclusive survey of the most up-to-date MHAs that are utilized for PEMFCs stack’s parameter identifications. More specifically, these MHAs are categorized into swarm-based, nature-based, physics-based and evolutionary-based. In which, more than 350 articles are allocated to attain the same goal and among them only 167 papers are addressed in this effort. Definitely, 15 swarm-based, 7 nature-based, 6 physics-based, 2 evolutionary-based and 4 others-based approaches are touched with comprehensive illustrations. Wherein, an overall summary is undertaken to methodically guide the reader to comprehend the main features of these algorithms. Therefore, the reader can systematically utilize these techniques to investigate PEMFCs’ parameter estimation. In addition, various categories of PEMFC’s models, several assessment criteria and many PEMFC commercial types are also thoroughly covered. In addition to that, 27 models are gathered and summarized in an attractive manner. Eventually, some insights and suggestions are presented in the conclusion for future research and for further room of improvements and investigations.
University Teachers During the First Lockdown Due to SARS-CoV-2 in Italy: Stress, Issues and Perceptions of Misconduct
Authors: Parlangeli Oronzo , Palmitesta Paola , Bracci Margherita , Marchigiani Enrica , Di Pomponio Ileana , Guidi Stefano 
Published: February 2022

AbstractWith the spread of the pandemic and the introduction of measures aimed at its containment, it is necessary to understand in specific national contexts how home quarantine has affected the psychophysical well-being of academics, and their ability to maintain integrity. To this end we constructed an online questionnaire to investigate the levels of stress, well-being, and work-life balance in relationship with living and working conditions. Moreover, the questionnaire was designed to obtain information about the perceived occurrence, increase or decrease of misconduct in research (e.g., research misconduct by colleagues) and professional relationships (e.g., misbehaviors between colleagues, from students and toward students). The questionnaire was administered online by contacting faculty at three universities in Tuscany, Italy, asking them to relate their experience during the first lockdown (March–May 2020). Faculty members were invited to complete the questionnaire by their institutional e-mail account. The final sample consisted of 581 respondents. The results showed that inadequacies of the equipment, and particularly poor internet connection, were significantly correlated with main issues reported, such as relationships with students and research activities. Female teachers primarily suffered from stressful conditions, lacked well-being, and experienced work-life imbalance. Stress levels were related to perceptions of the frequency of misconduct and of an increase in their frequency during the period of home quarantine. Female professors, when compared to their male counterparts, perceived misconduct from students as increased and more frequent in the period of quarantine. Results point to a gender issue that is likely to arise from conditions of domestic activities imbalance and that increases stress and misconduct perception.
Nomenclatural reappraisal of the Macroptilium gracile (Leguminosae) species complex
Authors: Berlingeri Chiara , Crespo Manuel B. , Calles Teodardo 
Published: February 2022

SummaryThe controversy regarding the status of the Macroptilium gracile species complex has been elucidated by the authors of this paper; nevertheless, some nomenclatural issues regarding the naming of the newly established variety have been found. In the present contribution, we discuss some nomenclatural aspects concerning the valid publication of the name Macroptilium gracile var. subcoriaceum (Benth.) Berlingeri, M.B.Crespo & Calles. After considering different nomenclatural evidence, the latter varietal name is to be considered superfluous and therefore, we establish a new combination (i.e., Macroptilium gracile var. longepedunculatum).
Phyllidiidae (Nudibranchia, Heterobranchia, Gastropoda): an integrative taxonomic approach including chemical analyses
Authors: Papu Adelfia , Bogdanov Alexander , Bara Robert , Kehraus Stefan , König Gabriele M. , Yonow Nathalie , Wägele Heike 
Published: February 2022

AbstractMembers of the widely distributed and common nudibranch family Phyllidiidae are often easily spotted in the marine environment because of their conspicuous colours and obvious presence on the reef. They are interesting with regard to their defensive chemical compounds that may lead to new drug discoveries. Despite their abundance, the family is also well known for its taxonomic problems and the difficulties in species identification due to very similarly coloured species and lack of morphological characters. In this study, phyllidiid species were analysed using an integrative approach. Molecular analysis of the mitochondrial genes 16S and CO1 was utilised, running phylogenetic analyses, species delimitation tests, and haplotype network analyses. Additionally, for the first time, external morphological characters were analysed, museum material was re-analysed, and chemical profiles were applied for characterising species. The analyses are based on sequences of 598 specimens collected in Indonesia by the team, with the addition of published sequences available on GenBank. This study comprises 11 species ofPhyllidia, seven species ofPhyllidiopsis, and at least 14 species ofPhyllidiella.Moreover, 11 species belonging to these three genera are probably new to science,Phyllidiopsis pipekiis synonymised withP. krempfi, andPhyllidiella albonigrais resurrected. Some of the external colouration previously used for species identification is shown to not be valid, but alternative characters are provided for most species. Chemical analyses led to species characterisation in a few examples, indicating that these species use particular sponge species as food; however, many species show a broad array of compounds and are therefore characterised more by their composition or profile than by distinct or unique compounds.
Von christlichem Antijudaismus im modernen Antisemitismus
Authors: Töllner Axel 
Published: February 2022

ZusammenfassungJudenfeindschaft wird heute häufig mit dem Begriff Antisemitismus gleichgesetzt. Dies gilt sowohl im allgemeinen Sprachgebrauch als auch in wissenschaftlichen Diskursen. Daneben gibt es jedoch Stimmen, die für eine begriffliche Differenzierung plädieren, weil Ziele und Erscheinungsformen der Judenfeindschaft zu unterschiedlich seien, als dass sie unter einem einzigen Oberbegriff subsummiert werden könnten. Zugleich lässt sich beobachten, dass eine begriffliche Unterscheidung zwischen älterem (religiösem) Antijudaismus und modernem (säkularem) Antisemitismus mitunter auch apologetische Ziele verfolgt.Der Artikel geht der Frage nach, ob und inwieweit ältere Antijudaismen bis heute relevant sind. Dabei soll anhand ausgewählter Beispiele gezeigt werden, dass sich die Entwicklungen und Transformationen von einer älteren, religiösen (meist christlichen) Judenfeindlichkeit zu einem modernen, säkularen Judenhass nicht in einem linearen Prozess vollzogen haben. Während sich bereits in christlich-spätantiken Texten säkulare antijüdische Stereotype finden, wirken auch in gegenwärtigen, scheinbar säkularen Kontexten christlich geprägte antijüdische Feindbilder und Denkmuster nach. Der Blick auf die Quellen soll verdeutlichen, dass Judenfeindschaft in der Regel ein komplexes System aus Feindbildern und Vorstellungen unterschiedlicher – religiöser und nichtreligiöser – Herkunft ist. Insofern versteht sich der Artikel auch als Plädoyer dafür, traditionellen, christlich geprägten und tradierten antijüdischen Stereotypen mehr Aufmerksamkeit zu widmen.