bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and Safety of Niraparib as Neoadjuvant Therapy in Advanced Ovarian Cancer With Homologous Recombination Deficiency (NANT): Study Protocol for a Prospective, Multicenter, Exploratory, Phase 2, Single-Arm Study
Authors: Zhou Dongchen , Liu Jiahao , Liu Ronghua , Li Huayi , Huang Yi , Ma Ding , Hong Li , Gao Qinglei 
Published: March 2022

BackgroundOvarian cancer (OC) is a heterogeneous gynecological malignancy with a poor prognosis as the majority of patients are diagnosed at an advanced stage. Neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) is recommended for patients who cannot achieve optimal cytoreduction or cannot endure primary debulking surgery (PDS). As there is an increased risk of chemoresistance for platinum-based NACT, it is important to investigate an alternative option. A Poly (ADP-ribose) polymerase inhibitor (PARPi), niraparib, has shown high anti-tumor activity, especially in homologous recombination deficiency (HRD) positive patients with OC. Thus, niraparib as a neoadjuvant treatment agent may help improve surgery accessibility and create survival benefits.MethodsThis multicenter, prospective, single-arm, open-label, phase II study plans to recruit 53 patients (aged 18-75 years) with newly diagnosed HRD positive, unresectable (Fagotti score ≥ 8 or upper abdominal computed tomography [CT] score ≥ 3) International Federation of Gynecology and Obstetrics (FIGO) stage III-IV OC. The HRD status was detected by next-generation sequencing and HRD positive patients will be counseled for study participation. Enrolled patients will receive niraparib capsules QD (200mg or 300mg per day) for two cycles (4 weeks/cycle). After neoadjuvant niraparib treatment, patients exhibiting complete response (CR), partial response (PR), or stable disease (SD) will undergo tumor reduction surgery and subsequent standard carboplatin/paclitaxel-based chemotherapy. The primary objectives include the objective response rate (ORR) and R0 resection rate. The rate of treatment interruption/termination and progression-free survival (PFS) will be secondary objectives. The study uses Simon’s optimal two-stage design (24 and 21 patients for the first and second stage respectively). The data manager will record all adverse events (AEs).DiscussionThis is the first prospective study to evaluate the effectiveness and safety of niraparib in neoadjuvant treatment for advanced OC. The result of this study will provide a solid base for further expanding the clinical applications of the PAPRi and exploring more therapeutic possibilities for patients with HRD positive advanced OC. Clinical Trial Registration: https://clinicaltrials.gov/, identifier NCT04507841.
The Emerging Role of MR Urography in Imaging Megaureters in Children
Authors: Świȩtoń Dominik , Grzywińska Małgorzata , Czarniak Piotr , Gołȩbiewski Andrzej , Durawa Agata , Teodorczyk Jacek , Kaszubowski Mariusz , Piskunowicz Maciej 
Published: March 2022

IntroductionMegaureter, described as ureter dilatation more than 7 mm in diameter, commonly associated with other anomalies, is still a diagnostic and therapeutic challenge. Magnetic resonance urography (MRU) appears as a promising method in urinary tract imaging, providing both anatomical and functional information. There are several postprocessing tools to assess renal function (including differential renal function) and severity of ureteral obstruction based on MRU. Still, the place of this method in the diagnostic algorithm of ureteropelvicalyceal dilatation with megaureter remains underestimated. Analysis of imaging findings in a group of children diagnosed with megaureter was done.Material and MethodsA retrospective analysis of magnetic resonance urography (MRU) was performed in 142 consecutive patients examined from January 2013 to September 2019. Twenty-five patients meeting the criteria of megaureter (dilatation more than 7 mm) in MRU were included in the further analysis. The MRU, ultrasound (US), and scintigraphy results were compared and analyzed together and compared with clinical data.ResultsThe sensitivity and specificity of US was comparable to the MRU in the assessment of upper urinary tract morphology (p &gt; 0.05). In five out of 25 children, megaureter was found in each kidney; in a single case, both poles of a duplex kidney were affected. In the diagnosis of ureter ectopia, the MRU was superior to the US for which sensitivity did not exceed 16%. The US showed limited value in the diagnostics of segmental ureter dysplasia as a cause of primary megaureter when compared with MRU. Four cases were visualized in MRU studies, whereas the US examination was negative (all confirmed during surgery). There was a moderate correlation between relative renal function between fMRU and scintigraphy (t = 0.721, p = 0.477) and in the severity of obstruction assessment between both methods (r = 0.441, p &lt; 0.05). However, in 10 kidneys with megaureter, the results in scintigraphy were inconclusive due to the signal from the megaureter imposing on the renal field.ConclusionsMRU seems to be a preferred method in the diagnostic algorithm for megaureter, providing both anatomical and functional information. MRU is superior to US and scintigraphy in diagnosing urinary tract anomalies with megaureter.
Acceptance Factors for In-Hospital Pharmacist Interventions in Daily Practice: A Retrospective Study
Authors: Durand Amaury , Gillibert André , Membre Sophie , Mondet Lisa , Lenglet Aurélie , Mary Aurélien 
Published: March 2022

Introduction: Performing pharmacist interventions (PIs) during the medication review helps to improve the quality of care. The acceptance by the physician of these PIs is a good indicator of the quality of this clinical pharmacy activity. The objective of this study was to determine, in the Amiens-Picardie teaching hospital (France), factors of acceptance in a variable environment of activity (central pharmacy, in the care units, computer assisted).Methods: All PIs transcribed by pharmacists on the Act-IP© site between November 2018 and April 2019 were analyzed using a complementary search in patient records. The environment, type, and clinical impact on patient health of each PI was collected. Linear mixed-effects models with a random pharmacist intercept were used to investigate the relationship between PI modalities and their chance of being accepted.Results: A total of 3,100 PIs were traced, of which 2,930 had been followed over time. Of these, 2,930 PIs, 1,504 (51.3%) were performed by a postgraduate pharmacist and 1,426 (48.7%) by a pharmacy resident, 1,623 (55.4%) were performed by verbal exchange, 455 (15.5%) by telephone, 846 (28.9%) by computer software, and 6 (0.2%) by paper. The clinical impact on patient health was major for 976 PIs (33.3%) and vital for 26 PIs (0.9%). According to the Anatomical Therapeutic Chemical Classification (ATC), they were mainly related to anti-infectives (30.3%), the nervous system (18.7%), and blood and blood-forming organs (17.3%). In total, 2,415 PIs (82.4%) were accepted. According to the multivariate model, a PI was more often accepted when it was transmitted orally rather than by software (+27.7%, 95% CI: +23.2 to +32.1%) and when it was transmitted to a medical resident rather than a postgraduate physician (+4.4%, 95% CI: 1.2–7.6%). In these cases, there was a major rather than a moderate clinical impact on patient health (+4.3%, 95% CI: +1.1–+7.6%).Conclusion: This study highlights the importance of the quality of the exchange with the prescriber and the prioritization of high-risk interventions as key points of medication review to improve rate of pharmacist interventions accepted by physician.
Shexiang Tongxin Dropping Pills Promote Macrophage Polarization-Induced Angiogenesis Against Coronary Microvascular Dysfunction via PI3K/Akt/mTORC1 Pathway
Authors: Lu Xiangyu , Yao Junkai , Li Changxiang , Cui Lingwen , Liu Yizhou , Liu Xiangning , Wang Gang , Dong Jianteng , Deng Qiong , Hu Yueyao , Guo Dongqing , Wang Wei , Li Chun 
Published: March 2022

Background: Accumulating evidence suggests that coronary microvascular dysfunction (CMD) is one of the important causes of coronary artery diseases. Angiogenesis can effectively improve CMD by increasing blood supply capacity, recovering cardiac function and poor hemodynamics. Clinical studies have approved Shexiang Tongxin dropping pill (STDP), which has exerted remarkable roles on ameliorating CMD, but the effects and mechanisms of STDPs on angiogenesis have not been clarified.Purpose: The purpose of this study was to elucidate the effects and potential mechanisms of STDPs on macrophage polarization-induced angiogenesis against CMD.Methods: Echocardiography, optical microangiography (OMAG), and histological examination were applied to evaluate cardioprotection and proangiogenic effects of STDPs on left anterior descending (LAD) ligation-induced CMD rats. In vitro, oxygen–glucose deprivation–reperfusion (OGD/R)-induced HUVEC model and LPS-stimulated bone marrow-derived macrophage (BMDM) model were established to observe the effects of STDPs on angiogenesis and M2 macrophage polarization.Results: STDPs improved cardiac function, increased microvascular density, and the number of M2 macrophages in the heart of CMD rats. In vitro, STDPs accelerated the proliferation, migration, and tube formation in OGD/R-induced HUVECs similar to the effects of VEGF-A. Furthermore, in LPS-stimulated BMDMs model, STDPs modulated M2 macrophage polarization and increased VEGF-A release via the PI3K/AKT/mTORC1 pathway.Conclusion: STDPs promoted macrophage polarization-induced angiogenesis against CMD via the PI3K/Akt/mTORC1 pathway. Our results demonstrated that the phenotype transformation of macrophages and stimulating the secretion of VEGF-A may be applied as novel cardioprotective targets for the treatment of CMD.
Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway
Authors: Bai Yang , Chen Jiaqi , Hu Weijian , Wang Lei , Wu Yulian , Yu Shi’an 
Published: March 2022

Background: Silibinin is widely utilized drug in various cancer treatments, though its application in cholangiocarcinoma has not yet been explored. For the first time, we evaluated the anticancer potential and underlying molecular mechanism of silibinin in treatment of cholangiocarcinoma treatment.Methods: HuCCT-1 and CCLP-1 cells were chosen to be an in vitro study model and were exposed to various concentrations of silibinin for indicated times. Cell viability was evaluated by the cell counting kit-8 (CCK-8) assay and half maximal inhibitory (IC50) concentrations were calculated. Cell proliferation capacity was determined through the use of colony formation and 5-Ethynyl-2′- deoxyuridine (EdU) assays. Cell apoptosis and cycle arrest were assessed by Live/Dead staining assay and flow cytometry (FCM). The protein levels of extracellular regulated protein kinases (ERK)/mitochondrial apoptotic pathway were evaluated through western blotting (WB). Mitochondrial membrane potential changes were determined via 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide (JC-1). A cholangiocarcinoma cell line xenograft model was used to assess the anti-tumor activity of silibinin in vivo.Results: Inhibition of the ERK protein by silibinin led to a significant decrease in mitochondrial membrane potential, which, in turn, caused Cytochrome C to be released from the mitochondria. The activation of downstream apoptotic pathways led to apoptosis of cholangiocarcinoma cells. In general, silibinin inhibited the growth of cholangiocarcinoma cell line xenograft tumors.Conclusions: Silibinin is able to inhibit cholangiocarcinoma through the ERK/mitochondrial apoptotic pathway, which makes silibinin a potential anti-tumor drug candidate for cholangiocarcinoma treatment.
Decreased Transition Rate From Situational Insomnia to Chronic Insomnia by One-Week Internet Cognitive Behavioral Treatments for Insomnia During the COVID-19 Pandemic
Authors: Feng Fei , Zhang Chenxi , Liang Hanwen , Xu Guojian , Luo Xian , Liu Shuai , Xu Yan , Yang Lulu , Zhang Li , Lin Lianhong , Zhang Bin 
Published: March 2022

PurposeThe purpose of the study was to determine the long-term effects of one-week self-guided internet cognitive behavioral treatments for insomnia (CBTI) on situational insomnia during the COVID-19 pandemic.Patients and MethodsThe participants with situational insomnia (n = 194) were recruited from March 2020 to April 2020 in Guangzhou, China. The insomnia severity index (ISI), pre-sleep arousal scale (PSAS), and hospital anxiety and depression scale (HADS) were evaluated at baseline and a one-week internet CBTI program was delivered to all individuals. The participants were divided into the complete treatment group (the participants completed all seven modules of the CBTI course, n = 75), and the incomplete treatment group (the participants completed 0–6 modules of the CBTI course, n = 119). A total of 135 participants completed the post-intervention assessments. At 3 months follow-up, a total of 117 participants (complete treatment group: n = 51; incomplete treatment group: n = 66) completed the assessments of the ISI, PSAS and HADS. The transition rate from situational insomnia to chronic insomnia (duration of insomnia ≥ 3 months and ISI ≥ 8) was calculated in the two groups. Linear mixed effect model was used to investigate the effect of group (between the two groups), time (baseline vs. follow-up), and interaction (group x time) on various questionnaire score.ResultsThe transition rate from situational insomnia to chronic insomnia was significantly lower in the complete treatment group compared to the incomplete treatment group (27.5%, 14/51 vs. 48.5%, 32/66, p = 0.023). There were significant differences in group effect (p = 0.032), time effect (p = 0.000) and group × time effect (p = 0.048) between the two groups in the ISI total score. The ISI total scores decreased in both groups during follow-up compared to their baseline values, with a greater magnitude of decrease in the complete treatment group. There were no significant group x time effects between the two groups in the PSAS-total score, PSAS-somatic, PSAS-cognitive score, HADS total score, HADS anxiety score or HADS depression score.ConclusionOur results suggested that one-week self-guided internet CBTI prevented the development of chronic insomnia from situational insomnia during the COVID-19 pandemic.
Natterin-Induced Neutrophilia Is Dependent on cGAS/STING Activation via Type I IFN Signaling Pathway
Authors: Lima Carla , Andrade-Barros Aline Ingrid , Bernardo Jefferson Thiago Gonçalves , Balogh Eniko , Quesniaux Valerie F. , Ryffel Bernhard , Lopes-Ferreira Monica 
Published: March 2022

Natterin is a potent pro-inflammatory fish molecule, inducing local and systemic IL-1β/IL-1R1-dependent neutrophilia mediated by non-canonical NLRP6 and NLRC4 inflammasome activation in mice, independent of NLRP3. In this work, we investigated whether Natterin activates mitochondrial damage, resulting in self-DNA leaks into the cytosol, and whether the DNA sensor cGAS and STING pathway participate in triggering the innate immune response. Employing a peritonitis mouse model, we found that the deficiency of the tlr2/tlr4, myd88 and trif results in decreased neutrophil influx to peritoneal cavities of mice, indicative that in addition to MyD88, TRIF contributes to neutrophilia triggered by TLR4 engagement by Natterin. Next, we demonstrated that gpcr91 deficiency in mice abolished the neutrophil recruitment after Natterin injection, but mice pre-treated with 2-deoxy-d-glucose that blocks glycolysis presented similar infiltration than WT Natterin-injected mice. In addition, we observed that, compared with the WT Natterin-injected mice, DPI and cyclosporin A treated mice had a lower number of neutrophils in the peritoneal exudate. The levels of dsDNA in the supernatant of the peritoneal exudate and processed IL-33 in the supernatant of the peritoneal exudate or cytoplasmic supernatant of the peritoneal cell lysate of WT Natterin-injected mice were several folds higher than those of the control mice. The recruitment of neutrophils to peritoneal cavity 2 h post-Natterin injection was intensely impaired in ifnar KO mice and partially in il-28r KO mice, but not in ifnγr KO mice. Finally, using cgas KO, sting KO, or irf3 KO mice we found that recruitment of neutrophils to peritoneal cavities was virtually abolished in response to Natterin. These findings reveal cytosolic DNA sensors as critical regulators for Natterin-induced neutrophilia.
Polyunsaturated Fatty Acids and Development of Children
Authors: Колупаева Е.А. 
Published: March 2022

В современной педиатрии большое внимание уделяется роли нутриентов, оказывающих влияние на развитие ребенка. Среди пищевых веществ особое место принадлежит длинноцепочечным полиненасыщенным жирным кислотам (ДЦПНЖК). Адекватное и сбалансированное поступление длинноцепочечных полиненасыщенных жирных кислот семейства ω-3 (ω-3 ДЦПНЖК) важно на протяжении всей жизни. Они играют одну из ключевых ролей в организме человека, напрямую влияя на состояние здоровья: регулируют липидный обмен, оказывают положительное влияние на развитие нервной системы в целом и когнитивные функции в частности, становление иммунитета и обладают противовоспалительной активностью. Приведены результаты современных экспериментальных и клинических исследований, анализ физиологических эффектов на молекулярном уровне и биологическая роль ДЦПНЖК. Необходимость адекватного употребления ω-3 ДЦПНЖК в раннем дошкольном периоде и в начальной школе подтверждается многочисленными результатами клинических исследований.
In modern pediatrics, much attention is paid to the role of nutrients that affect the development of the child. Among food substances, a special place belongs to long-chain polyunsaturated fatty acids (LCPUFA). Adequate and balanced intake of long-chain polyunsaturated fatty acids of the ω-3 family (ω-3 LCPUFA) is important throughout life. They play one of the key roles in the human body, directly affecting the state of health: they regulate lipid metabolism, have a positive effect on the development of the nervous system as a whole and cognitive functions in particular, the formation of immunity, and have anti-inflammatory activity. The results of modern experimental and clinical studies, the analysis of physiological effects at the molecular level and the biological role of LCPUFA are presented. The need for adequate use of ω-3 LCPUFA in the early preschool period and in elementary school is confirmed by numerous results of clinical studies.
Post-partum Mothers’ Knowledge Related to Vitamin A Consumption in Tanjung Uncang Health Center Batam City in 2021
Authors: Yunita Prasida , Silvia Mona  
Published: March 2022

This study aims to determine the relationship between knowledge of postpartum mothers and the behavior of consuming vitamin A capsules in the working area of Tanjung Uncang Public Health Center, Batam city in 2021. This study used a cross sectional design. The research was conducted in September 2021 in the working area of the Tanjung Uncang Health Center UPT, Batam city. The sampling technique used is simple random sampling technique. Research respondents consisted of 85 mothers in the postpartum period. Most of the respondents have less knowledge (50.6%). Meanwhile, the behavior of consuming vitamin A during the puerperium was considered good (52.9%). Based on chi-square analysis, p value = 0.015 (p <0.05), so it can be concluded that there is a relationship between knowledge of postpartum mothers and behavior of consuming vitamin A capsules. In conclusion, most of the mothers during the postpartum period have less knowledge and consumption behavior. vitamin A during the good puerperium. There is a relationship between knowledge and behavior in consuming vitamin A capsules during the puerperium.
Report on Three Stellar Occultations by the Excited Kuiper Belt Object 2002 MS4.
Authors: Zemouri Rami , Ceravolo Peter , Kavelaars JJ , Bridges Terry 
Published: March 2022

Abstract
We report on three stellar occultation events by the Kuiper Belt object 2002 MS4, observed using a 300 mm telescope on Anarchist Mountain, BC, Canada. Using the three events we have determined chord diameters of (810 ± 70) km, (630 ± 140) km, and (780 ± 70) km. All of these diameters are consistent with those reported from previous occultation events. Based on these data we estimate that 2002 MS4 is at least 810 ± 70 km in diameter These events also provide high-precision sky positions for 2002 MS4 at the exact time of the occultation, which can be used to refine the orbital ephemeris of this target, improving predictions of future events. All data and processing outputs described in this Research Note can be retrieved from: 10.11570/22.0001
A Parameterized Model for Differential Galaxy Counts at Any Wavelength
Authors: Wilson Tom J. 
Published: March 2022

Abstract
Certain astronomy problems, such as the probabilistic cross-matching algorithms of Wilson & Naylor, require descriptions of galaxy counts as a function of brightness in many different filter sets, for which we often lack dedicated observations. With this motivation in mind, I present a simple model for calculating differential galaxy counts for an arbitrary bandpass or wavelength. The model uses a double Schechter function to describe the number density of galaxies as a function of absolute magnitude, including redshift-driven galaxy evolution, for both “blue” and “red” galaxy types. Collating previously derived values for the parameterization of the evolving Schechter function—

M

0

*

,

ϕ

0

*

, P, Q, and α—I fit the dependencies of these parameters as a function of wavelength, allowing for the tabulation of differential galaxy counts in a new filter for which observations are unavailable. Finally, I briefly compare the model with some differential galaxy counts obtained from the literature.
Musculoskeletal Disorders in Nurses in Hospitals
Authors: Stanchev Verislav , Vangelova Katya 
Published: March 2022

Background Healthcare is a sector with a high risk of musculoskeletal disorders. The work of nurses in a hospital is associated with stress, prolonged work, uncomfortable working postures, bending and twisting of the body and etc.
Aim: To identify the risk factors for the frequency and localization of musculoskeletal complaints and diagnosed diseases of the musculoskeletal system in nurses in hospitals.
Methods: The study is cross-sectional and comprised 1412 nurses female nurses from 19 hospitals in Sofia having an average age of 50.3±9.9 years. An ergonomic analysis of workplaces in hospitals was made. A survey was conducted in relation to the workplace, the workload, the working posture and movements; Standardized Nordic questionnaires for the analysis of musculoskeletal symptoms were used, BMI. Information on musculoskeletal diseases diagnosed by a doctor was collected with Work ability index (WAI). The statistical analyses were made using SPSS.
Results: The frequency of musculoskeletal complaints is high, complaints in the lower back being in the lead with 74.2%, followed by the back, neck and shoulders. A musculoskeletal disorder, diagnosed by a doctor, occurs in 35.6% of the individuals. Widespread is the prolonged work in a standing position, awkward working postures, bending, twisting and stretching. The data from the regression analysis show that the work with bending, twisting and stretching, prolonged work in a standing position and BMI are predictors of musculoskeletal complaints.
Conclusion: The results indicate lack of good workplace organisation and equipment. The activity involves prolonged work in a standing position, awkward working postures and work with bending and twisting of the body. High is the incidence of musculoskeletal disorders and the undergone treatment related to them.
Key words: musculoskeletal disorders, workplace, working postures, nurses, hospitals.