bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual dimorphic response to rituximab treatment: A longitudinal observational study in a large cohort of patients with primary membranous nephropathy and persistent nephrotic syndrome
Authors: Perna Annalisa , Ruggiero Barbara , Podestà Manuel Alfredo , Perico Luca , Orisio Silvia , Debiec Hanna , Remuzzi Giuseppe , Ruggenenti Piero 
Published: September 2022

Rituximab is one of the first-line therapies for patients with membranous nephropathy (MN) at high risk of progression towards kidney failure. We investigated whether the response to Rituximab was affected by sex and anti-PLA2R antibody levels in 204 consecutive patients (148 males and 56 females) with biopsy-proven MN who were referred to the Nephrology Unit of the Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII from March 2001 to October 2016 and managed conservatively for at least 6 months. The primary outcome was a combined endpoint of complete (proteinuria &lt;0.3 g/24 h) or partial (proteinuria &lt;3.0 g/24 h and &gt;50% reduction vs. baseline) remission. Patients gave written informed consent to Rituximab treatment. The study was internally funded. No pharmaceutical company was involved. Anti-PLA2R antibodies were detectable in 125 patients (61.3%). At multivariable analyses, female gender (p = 0.0198) and lower serum creatinine levels (p = 0.0108) emerged as independent predictors of better outcome (p = 0.0198). The predictive value of proteinuria (p = 0.054) and anti-PLA2R titer (p = 0.0766) was borderline significant. Over a median (IQR) of 24.8 (12.0–36.0) months, 40 females (71.4%) progressed to the combined endpoint compared with 73 males (49.3%). Anti-PLA2R titers at baseline [127.6 (35.7-310.8) vs. 110.1 (39.9–226.7) RU/ml] and after Rituximab treatment were similar between the sexes. However, the event rate was significantly higher in females than in males [HR (95%): 2.12 (1.44–3.12), p = 0.0001]. Forty-five of the 62 patients (72.3%) with anti-PLA2R titer below the median progressed to the combined endpoint versus 35 of the 63 (55.6%) with higher titer [HR (95%): 1.97 (1.26–3.07), p &lt; 0.0029]. The highest probability of progressing to the combined endpoint was observed in females with anti-PLA2R antibody titer below the median (86.7%), followed by females with anti-PLA2R antibody titer above the median (83.3%), males with titer below the median (68.1%), and males with titer above the median (44.4%). This trend was statistically significant (p = 0.0023). Similar findings were observed for complete remission (proteinuria &lt;0.3 g/24 h) and after analysis adjustments for baseline serum creatinine. Thus, despite similar immunological features, females were more resilient to renal injury following Rituximab therapy. These findings will hopefully open new avenues to identify the molecular pathways underlying sex-related nephroprotective effects.
RETRACTED: The COVID-19 fear, anxiety, and resilience among emergency nurses
Authors: Karimi Khordeh Negar , Dehvan Fazel , Dalvand Sahar , Repišti Selman , Ghanei Gheshlagh Reza 
Published: September 2022

BackgroundBesides physical complications, COVID-19 is associated with psychological issues such as fear and anxiety. High resilience in nurses enables them to adopt positive coping mechanisms and successfully operate in the stressful environment of COVID-19 wards. The present study aimed to evaluate the correlation between COVID-19 fear and anxiety with resilience in the emergency nurses of the hospital affiliated with Kurdistan University of Medical Sciences (west of Iran) in 2021.Materials and methodsThis cross-sectional study was conducted on 295 emergency nurses of selected hospitals in Kurdistan province, Iran, in 2021. Data were collected using a demographic questionnaire, Fear of COVID-19 Scale (FCV-19S), Corona Disease Anxiety Scale (CDAS), and Connor-Davidson Resilience Scale (CD-RISC). Data analysis was performed in R software version 3.6.3.ResultsThe mean scores of resilience, COVID-19 fear, and COVID-19 anxiety were 55.07 ± 19.82 (ranging from 0 to 100), 20 ± 7.37 (ranging from 7 to 35) and 36.48 ± 13.21 (ranging from 18 to 54) respectively. There was a negative and significant correlation between resilience with COVID-19 fear (r = −0.449, p = 0.001), COVID-19 anxiety (r = 0.458, p = 0.001). A significant correlation was observed between COVID-19 fear and anxiety, which indicated that if the other demographic variables remained unchanged, a one-unit increase in COVID-19 fear and anxiety decreased the mean resilience score by −0.66 (P = 0.008) and −0.34 (P = 0.015), respectively.ConclusionCOVID-19 fear and anxiety were significantly correlated. Therefore, providing training courses for promoting resilience could reduce the fear and anxiety of nurses during the COVID-19 pandemic.
Diet-related knowledge, attitudes, and behaviors among young and middle-aged individuals with high-normal blood pressure: A cross-sectional study in China
Authors: Mu Tingyu , Xu Rixiang , Zhu Qianyin , Chen Lingshan , Dong Die , Xu Jiayi , Shen Cuizhen 
Published: September 2022

BackgroundDietary modifications play an important role in the prevention and management of high-normal blood pressure (BP). The aim of this study was to investigate diet-related knowledge, attitudes, and behaviors, and the socio-demographic determinants of these, among young and middle-aged Chinese individuals with high-normal BP.MethodsData from the 2015 China Health and Nutrition Survey (CHNS) were analyzed in this study. A total of 1,756 subjects with high-normal BP were included. A chi-square test and binary logistic regression analysis were conducted to identify the risk factors toward diet-related knowledge, attitudes, and behaviors.ResultsA total of 37.4% of the participants knew about the Chinese Food Pagoda (CFP) or the Dietary Guidelines for Chinese Residents (DGCR). Overall, 39.8% of the subjects were classified as having adequate diet-related knowledge literacy, 27.8% reported positive diet-related attitudes to healthy eating, and 35.3% reportedly looked for nutrition knowledge. Of note, 72.4% and 80.1% of the participants reported liking to eat fruits and vegetables, respectively. Individuals with a middle school education [odds ratio (OR) = 1.784, 95% CI = 1.236–2.576], high school/vocational education (OR = 1.944, 95% CI = 1.305–2.896), and college degree or above (OR = 2.089, 95% CI = 1.341–3.322), who were living in a rural area (OR = 1.311, 95% CI = 1.048–1.639), proactively looking for nutrition knowledge (OR = 1.529, 95% CI = 1.227–1.906), and reported liking to eat vegetables (OR = 1.939, 95% CI = 1.409–2.688), were more likely to have sufficient dietary knowledge literacy. Managers (OR = 1.655, 95% CI = 1.039–2.635) were more likely to have positive dietary attitudes. Female gender (OR = 1.396, 95% CI = 1.089–1.790), high school/vocational school education (OR = 2.071, 95% CI = 1.269–3.379), college degree and above (OR = 2.207, 95% CI = 1.262–3.862), knowledge about the CFP or DGCR (OR = 8.138, 95% CI = 6.326–10.468), and sufficient dietary knowledge literacy (OR = 1.338, 95% CI = 1.050–1.705) were associated with an increased likelihood of looking for nutrition knowledge.ConclusionIndividuals with high-normal BP, predominantly males, living in rural area, with lower education, farmers, workers, service workers, and workers in the non-government employment unit may have poor diet-related knowledge, attitudes, and behaviors.
Better safe than sorry: Evaluating the implementation process of a home-visitation intervention aimed at preventing unintentional childhood injuries in the hospital setting
Authors: Shalev Ligat , Rudolf Mary C. J. , Spitzer Sivan 
Published: September 2022

BackgroundChild home injuries prevention interventions have rarely been implemented in hospitals. The SHABI program (“Keeping our Children Safe”; in Hebrew: “SHomrim Al BetIchut Yeladenu”) recruits at-risk families arriving with child injury to the Emergency Department. Medical/nursing students conduct two home visits four months apart, providing safety equipment and guidance. One hundred thirty-five families had a first visit and 98 completed the second. Fifty percentage of families were ultra-Orthodox Jews, 11% Arab, and 28% had ≥3 preschool children. We investigated SHABI's implementation using the Consolidated Framework for Implementation Research (CFIR).MethodsBetween May 2018 and March 2021 SHABI was implemented in the Emergency Department of a hospital in Israel's northern periphery, an area with high child injury rates. The Implementation process was examined through Emergency Department medical records and tracking registries, hospital management, nurses', and home visitors' meetings notes (n = 9), and a research diary. Hospital's inner setting and SHABI's characteristics were evaluated through interviews with hospital management, nurses, and home visitors 8 months after baseline (n = 18). Home visitors' characteristics were evaluated through interviews, post-visit questionnaire on challenges encountered (n = 233), families' perceptions of SHABI and home visitors' skills through telephone interviews (n = 212); and home visitors awareness of dangers at home (n = 8) baseline and 8 months later. Qualitative data were analyzed through explanatory content analysis according to CFIR constructs. Quantitative data were analyzed using X2 and Wilcoxon test for dependent subgroups.ResultsDespite alignment between SHABI and the hospital's mission, structural hospital-community disconnect prevented implementation as planned, requiring adaptation and collaboration with the medical school to overcome this barrier. Recruitment was included in the initial patient triage process but was only partially successful. Medical/nursing students were recruited as home visitors, and following training proved competent. Children were a distraction during the visits, but home visitors developed strategies to overcome this.ConclusionsInjury prevention programs in hospitals have significant benefits. Identifying implementation barriers and facilitators allowed implementers to make adaptations and cope with the innovative implementation setting. Models of cooperation between hospital, community and other clinical settings should be further examined.
An internet based virtual reality intervention for preventing posttraumatic stress disorder
Authors: Freedman Sara A. , Dayan Ehud , Eitan Renana 
Published: September 2022

Introduction: Research examining the prevention of Posttraumatic Stress Disorder (PTSD) has shown that selective treatments to those with high symptom levels, using trauma focused CBT are relatively successful in reducing symptoms and preventing chronic PTSD. However, uptake of these early treatments is often low. This study aimed to provide an internet based Virtual Reality treatment to overcome some of these barriers to early treatment.Method: The study received IRB approval from Hadassah Hospital (HMO 0056-013); its ClinicalTrials.gov identifier is NCT01760213. Recent survivors of motor vehicle accidents (N = 1,500) were assessed by telephone and online questionnaires. Patients meeting study criteria were randomly assigned to a Virtual Reality internet-based trauma-focused cognitive behavioral therapy (CBT) or waitlist control.Results: the majority of subjects recruited did not meet study criteria or were unwilling to participate. 14 subjects were randomly assigned to treatment or waitlist control. Results indicate that both groups show a decline in PTSD symptoms at follow up, with no significant differences between groups.Discussion: prevention of PTSD is a challenging goal, and internet-based interventions may play a role in this. The current study was not able to recruit sufficient participants to draw conclusions regarding the efficacy of the treatment. Proving services via the internet may not reduce barriers to care in this population.Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/NCT01760213?term=Freedman&amp;cond=PTSD&amp;cntry=IL&amp;draw=2&amp;rank=2, identifier NCT01760213.
Case report: Primary pleural squamous cell carcinoma in a 68-year-old male
Authors: Zhong Chuan , Zhou Haining , Rami-Porta Ramón , Zhao Yunfei 
Published: September 2022

IntroductionPrimary pleural squamous cell carcinoma (PPSCC) is a sporadic disease that is rarely reported in the literature. Due to its low incidence, the pathogenesis of PPSCC is unknown.Case summaryWe report a case of a 68-year-old male with PPSCC and sizable pulmonary bullae. Two months after complete resection of both lesions, a total dose of 50 Gy radiotherapy was administered over the operative field. After more than a year of follow-up, the patient is in steady condition without any sign of recurrence.ConclusionSince PPSCC is rarely reported, our case proposed that complete surgical resection combined with radiotherapy may be a promising therapeutic approach.
Administración y "fenómeno de mercado": choque de convivencia en la economía territorial
Authors: Popov Rinad A , Prokhorova Victoria V , Zakharova Elena N , Ordynskaya Marina E , Gabidullina Chulpan F 
Published: September 2022

Achievement of an effective balance between government regulation of business and free competition is the goal of any progressive economy, and attention to this issue is completely justified. This study aims to analyze the concept of administration and "market phenomenon: the collision of coexistence in territorial economy. To do so, the systemic, institutional, reproductive approaches are utilized. Based on the results, the need for a constructive solution to this problem leads to a logical conclusion about the need to create an administrative and economic system to regulate social practice of a new type, based on the principles of maximizing freedom of expression and economic initiative within the boundaries of social expediency. This regulatory system presupposes the presence of continuous monitoring of reproduction processes, the timely identification of constraints on the implementation of the economic strategy and an urgent corrective administrative and economic impact on these elements. The solution to this problem seems possible through the multi-level implementation of BIM technologies in economic administration within the Russian territorial and economic practice, built on the principles of network modeling of the reproduction process.
Advances in contemporary means to assess exchange-traded financial assets
Authors: Koren Andrey V , Danilovskikh Tatiana E 
Published: September 2022

Evaluation of exchange-traded financial assets fair is regarded as an essential duty in contemporary economics. Nonetheless, the significance of approaches for assessment and anticipation of potential costs is perpetually altering. This article offers a comparative examination of technical and fundamental analysis techniques, revealing their benefits and drawbacks. That features of Fundamental analysis (FA) as income, profit, profitability and the debt burden level are deemed in depth, the extent of their impact on the securities’ price is investigated. Following the study, conclusions are made regarding the progressively narrow utilization of technical examination throughout short-term and investments issue solution. An anticipation is for a more fall of FA significance as the primary technique of evaluation. To acquire those conclusions, the study utilized statistical data reveal the characteristics of exchange-traded assets while organizations got into IPOs. The information acquired demonstrate a vivid relation between the innovation element of businesses, market share and the costs. Meanwhile, the organization profit has eventually deceased to be the primary features of the business over the course of its evaluation. Plus, they investigated the relation between the fairness of exchange-traded asset assessments and quantitative easing (QE) schemes.
APEX: Characterizing Attack Behaviors from Network Anomalies
Authors: Kalupahana Liyanage Kushan Sudheera , Tian Zixu , Divakaran Dinil Mon , Chan Mun Choon , Gurusamy Mohan 
Published: September 2022

<p> Networks regularly face various threats and attacks that manifest in their communication traffic. Recent works proposed unsupervised approaches, e.g., using a variational autoencoder, that are not only effective in detecting anomalies in network traffic, but also practical as they do not require ground truth or labeled data. However, the problem of characterizing anomalies into different attack behaviors is still less explored; in this work, we study this specific problem. We develop APEX, a framework that employs data mining approaches in a semi-supervised way to extract the attack patterns from anomalous traffic and links them to specific attack types. APEX comprises two levels of mining: the first level extracts patterns in anomalous network flows, and the second level characterizes behaviors in the extracted patterns into different attack classes. We carry out extensive experiments on real network traces obtained from the MAWI traffic archive. The evaluations demonstrate that APEX is effective in extracting distinguishable behaviors of network attacks from anomalous traffic, and provide useful insights to security analysts investigating the anomalies. </p>
A Unified Theory of Radiations (Fields)
Authors: Geyi Wen 
Published: September 2022

<p> A unified theory of fields (UTF) or radiations is explored in this article. The UTF unveils that an arbitrary static field (either scalar or vectorial, called an ontological field) in an inertial system (static system) will merge as two vector fields in an inertial system moving relative to the static system, which satisfy Maxwell-like equations. Therefore, the Maxwell equations are not only valid for describing the EM fields but also for any physical fields for which an ontological field exists. The UTF is based on the theory of special relativity and the Helmholtz theorem. In order to find how the vector field changes in different inertial systems, one only needs to examine how the curl and divergence of the vector field transform. As applications, the Maxwell equations for EM field and the Maxwell-like equations for the gravitational field are derived from the UTF, and the latter are also derived from the Einstein field equations in the theory of general relativity. Some universal laws of nature are shown to be derivable from the UTF. </p>
Implementasi Diplomasi Lingkungan Indonesia Dalam Penanggulangan Kebakaran Hutan Kabupaten Kepulauan Meranti, Riau
Authors: Robertua Verdinand 
Published: September 2022

Di Indonesia, kebakaran hutan dan lahan telah mengakibatkan perubahan pada lingkungan yang berpengaruh pada kerusakan alam dan resiko bagi kehidupan manusia, seperti kerusakan ekosistem, emisi karbon, masalah kesehatan, sosial dan kerugian ekonomi. Kondisi dapat memicu perubahan iklim yang sangat drastis. Melihat kondisi geografis, Indonesia adalah salah satu negara yang rentan akan perubahan iklim. Komitmen pemerintah Indonesia di dunia internasional menjadi suatu hal yang harus dikaji lebih dalam mengingat hal ini menjadi bagian dari kepentingan nasional Indonesia. Diplomasi lingkungan Indonesia menjadi dipertanyakan efektivitasnya melihat implementasi perjanjian Paris dan Tujuan Pembangunan Berkelanjutan (TPB) di Indonesia. Peran pemerintah kabupaten dan kota menjadi sentral dalam implementasi Perjanjian Paris dan TPB dan perlu diteliti lebih dalam. Berdasarkan hasil wawancara dengan narasumber kunci, masih banyaknya retorika dan realita yang terjadi dari tingkatan instansi yang sifatnya top-down. Masih banyaknya ketidaksinambungan kebijakan dari pemerintah pusat ke pemerintah daerah yang mengakibatkan restorasi dan penanggulangan kebakaran gambut tidak berkelanjutan. Dengan menggunakan tipologi fragmentasi Biermann, peneliti mengidentifikasi fragmentasi kerjasama yang belum mampu menghadapi ancaman perubahan iklim. Pemerintah kabupaten Kepulauan Meranti tidak dilibatkan secara optimal dalam perencanaan tata ruang dan tata lahan serta prioritas lokal. Bukan hanya itu dengan tipologi Ibon juga peneliti melihat peranan tingkatan pemerintah dengan permasalahan Meranti ini. Berbekal hasil wawancara tersebut, penelitian ini merekomendasikan agar Pemerintah Indonesia secara serius mengejar fragmentasi sinergi dengan melibatkan pemerintah kabupaten dan kota dalam implementasi Perjanjian Paris dan TPB.
Exploring Perceptions of Higher Education Internationalization: An Academic Expatriates' Perspective
Authors: Alpenidze Onise , Fenech Roberta , Baguant Priya 
Published: September 2022

The current research explores the perceptions of academic expatriates in the UAE on higher education internationalization. A qualitative approach was applied to this study as it was believed to generate a comprehensive, actual, and thorough understanding of participants' insights on the topic. Thirty academic expatriates were selected to create focus groups to discuss the research question. Focus groups were held semi-structured, allowing researchers and participants to encourage exhaustive discussions on pre-defined questions and beyond. As a result of thematic analysis, seven main themes and 29 related codes were identified. The consistency of coding was calculated using intra-class correlation to achieve the trustworthiness of the findings. Further analysis and discussion allowed researchers to explore the topic in-depth. The research has reflected on the perceived readiness of academic staff in the internationalization of higher education. Individual, institutional, and global factors are among the main variables that affect shaping faculty perceptions on internationalization and their willingness to participate in the process. The main findings of this study are that awareness of internationalization leads to faculty acceptance and engagement, as well as perceptions of challenges related to internationalization. Perceived readiness is also influenced by potential individual opportunities that may result from internationalization.

Received: 11 June 2022 / Accepted: 19 August 2022 / Published: 2 September 2022
Influence of Legal Traditions and Legal Culture on the Institution of Marriage Contracts and the Possibility of its Improvement: The Experience of Kazakhstan
Authors: Zhunussova Togzhan Bakhtybaevna 
Published: September 2022

Since the Republic of Kazakhstan gained independence, it developed market relations and established private property as the leading type of ownership. Such fundamental changes required corresponding changes in the system of law, including family law. However, such reforms often depend on the mindset, legal culture, and legal traditions that have developed in society. In Kazakhstan, the practice of concluding marriage contracts (which govern property relations between spouses) has not developed or been seriously limited. Thus, this sphere needs to be considered for further improvement. The study aims at determining the social and legal factors affecting the regulation of marital relations through the conclusion of marriage contracts in Kazakhstan. Based on an expert survey, the authors of the article have revealed both positive and negative aspects of concluding a marriage contract and considered the main reasons for a small number of such contracts concluded between citizens of Kazakhstan. There a marriage contract is a special extrajudicial way of settling property relations between spouses that may arise in the future, a means of protecting their property rights and exercising property obligations. However, this method of regulation and protection is resorted to families with a high-income level and great life experience and often in special life situations.

Received: 6 June 2022 / Accepted: 15 August 2022 / Published: 2 September 2022