bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dry reforming of methane over Ni/ZrO2 and NiCu/ZrO2 thin layer nanocatalysts in a microchannel reactor: The effect of coating time
Authors: Kazemi Pouya , Moradi Gholamreza 
Published: September 2022

AbstractIn this study, the performance of thin film Ni/ZrO2 and NiCu/ZrO2 catalysts in a microchannel reactor in the dry methane reforming reaction (DRM) is investigated. Thin film nanocatalysts are prepared by the physical vapor deposition (PVD) method. GIXRD, FESEM‐Cross, FESEM‐Surface, and EDX analyzes are used to evaluate the properties of thin film nanostructures. The results show that in addition to the addition of copper as a promoter, a change in the coating time causes a change in the formation of the thin layer and the growth mechanism of the layers. Reactor tests are evaluated at temperatures ranging from 700°C to 800°C, at P = 1 atm, with a CH4:CO2 ratio of 1. Results of this study are compared with two other studies in fixed bed reactors that show the microchannel reactor has better performance. The presence of copper on Ni/ZrO2 could have significant effects on the stability of hydrogen production and the reduction of carbon deposition. Thin film Ni/ZrO2 catalyst with 2 min coating time and NiCu/ZrO2 catalyst with NiCu weight ratio of 4: 1 with 1 min coating time at 800°C show the best performance in terms of hydrogen production and H2/CO ratio (1.43 for a sample of Ni/ZrO2 and 1.68 for a sample of NiCu/ZrO2).
Experimental studies of solar still with tar‐coated blue metal stones: Energy and exergy study
Authors: Arani Rajendra Prasad , Vaithilingam Sivakumar , Selvaraj Kalaivani , Afzal Asif 
Published: September 2022

AbstractIn the present manuscript, performance studies of Solar Still (SS) were studied for the climatic conditions of Erode, India. Three different experiments were conducted: Conventional SS (CSS), CSS incorporated with blue metal stones, and CSS incorporated with tar‐coated blue metal stones. Furthermore, the energy and exergy efficiency of the CSS is evaluated. The daily‐distilled yield by incorporating the tar‐coated blue metal stones in CSS is 3.21 Kg and blue metal stones in CSS is 2.89 Kg with augmentation of 34.4% and 27%, respectively than the CSS. The distilled water production during daytime (8 a.m.–6 p.m.) from the CSS, CSS incorporated with blue metal stones, and CSS incorporated with tar‐coated blue metal stones is 2.02, 2.59, and 2.83 kg, respectively. Similarly distilled water production during nighttime (7 p.m. to 11 p.m.) is 0.08, 0.29, and 0.39 kg, respectively. The distilled water production during daytime and nighttime from the CSS incorporated with tar‐coated blue metal stones and CSS incorporated with blue metal stones are 28.3%, 22%, 78.6%, and 71.7% higher than the day‐time and night‐time yield from the CSS. Also, the energy and exergy efficiency of the CSS incorporated with tar‐coated blue metal stones and CSS incorporated with blue metal stones is 21.6% and 1.63%, and 20% and 1.4%, respectively.
The long‐term surgical outcomes of low‐grade epilepsy‐associated neuroepithelial tumors
Authors: Xie Ming‐Guo , Wang Xiong‐Fei , Qiao Jiao , Zhou Jian , Guan Yu‐Guang , Liu Chang‐Qing , Zhao Meng , Li Tian‐Fu , Luan Guo‐Ming 
Published: September 2022

AbstractObjectiveThis study aimed to evaluate the surgical outcomes and relevant prognostic factors in patients with low‐grade epilepsy‐associated neuroepithelial tumors (LEAT) and, especially, to develop a scoring system to predict postoperative seizure outcomes.MethodsThe clinical data of patients who underwent epilepsy surgery for LEAT were retrospectively studied. The surgical outcomes of seizure and neurological statuses in patients were evaluated using Engel classification and modified Rankin Scale (mRS) scoring, respectively. A scoring system of seizure outcomes was constructed based on the weight of the β‐coefficient estimate of each predictor in the final multivariate predicting model of seizure outcomes.ResultsOf the 287 patients (106 female) enrolled, the median age was 19 years at surgery and 10 years at seizure onset, with a median duration of epilepsy of 60 months. Among 258 patients who were followed up for at least 12 months, 215 (83.3%) patients had a favorable seizure outcome (Engel class I) after surgery, and 43 (16.7%) patients had an unfavorable seizure outcome; longer duration of epilepsy, discordant magnetoencephalography (MEG) findings, and acute postoperative seizures were significantly included in the scoring system to predict unfavorable seizure outcomes, and in the scoring system, accumulated scoring of 0–19 scores was recorded, which were finally grouped into three risk levels: low risk (risk < 30%), medium risk (30% ≤ risk < 70%), and high risk (risk ≥ 70%). In addition, favorable neurological outcomes (mRS score 0–1) were recorded in 187 (72.5%) patients, while unfavorable neurological outcomes were recorded in 71 (27.5%) patients, which were significantly related to poor seizure control, older age at surgery, and longer duration of epilepsy and hospitalization time.SignificanceThe long‐term surgical outcomes of LEAT after surgery were satisfactory. A scoring system for predicting unfavorable seizure outcomes with different risk levels was developed, which could partly guide clinical treatments of LEAT.
Effectiveness of perampanel as the only add‐on: Retrospective, multicenter, observational real‐life study on epilepsy patients
Authors: Gasparini Sara , Ferlazzo Edoardo , Neri Sabrina , Cianci Vittoria , Iudice Alfonso , Bisulli Francesca , Bonanni Paolo , Caggia Emanuele , D'Aniello Alfredo , Di Bonaventura Carlo , DiFrancesco Jacopo C. , Domina Elisabetta , Dono Fedele , Gambardella Antonio , Marini Carla , Marrelli Alfonso , Matricardi Sara , Morano Alessandra , Paladin Francesco , Renna Rosaria , Striano Pasquale , Pascarella Angelo , Ascoli Michele , Aguglia Umberto ,   PEROC Study Group
Published: September 2022

AbstractObjectivePerampanel (PER) is indicated as adjunctive antiseizure medication (ASM) in adolescents and adults with epilepsy. Data from clinical trials show good efficacy and tolerability, while limited information is available on the routine clinical use of PER, especially when used as only add‐on treatment.MethodsWe performed an observational, retrospective, multicenter study on people with focal or generalized epilepsy aged >12 years, consecutively recruited from 52 Italian epilepsy centers. All patients received PER as the only add‐on treatment to a background ASM according to standard clinical practice. Retention rate, seizure frequency, and adverse events were recorded at 3, 6, and 12 months after PER introduction. Subanalyses by early or late use of PER and by concomitant ASM were also conducted.ResultsFive hundred and three patients were included (age 36.5 ± 19.9 years). Eighty‐one percent had focal epilepsy. Overall, the retention rate was very high in the whole group (89% at 12 months) according with efficacy measures. No major differences were observed in the subanalyses, although patients who used PER as early add‐on, as compared with late add‐on, more often reached early seizure freedom at 3‐month follow‐up (66% vs 53%, P = .05). Treatment‐emergent adverse events occurred in 25%, far less commonly than in PER randomized trials.SignificanceThis study confirms the good efficacy and safety of PER for focal or generalized epilepsy in real‐life conditions. We provide robust data about its effectiveness as only add‐on treatment even in patients with a long‐standing history of epilepsy and previously treated with many ASMs.
Effect of boundary condition on the cyclic response of I‐shaped steel columns: Two‐story subassemblage versus isolated column tests
Authors: Chou Chung‐Che , Lai Yun‐Chuan , Xiong Hou‐Chun , Lin Te‐Hung , Uang Chia‐Ming , Mosqueda Gilberto , Ozkula Gulen , El‐Tawil Sherif , McCormick Jason P. 
Published: September 2022

AbstractRecent studies on isolated steel columns under combined axial load and cyclic lateral drift showed that the column response is affected by the boundary condition. To consider more realistic boundary conditions of first‐story columns in a frame, two‐and‐a‐half story beam‐column subassemblages were tested to investigate their behavior under reversed cyclic loading. The subassemblages, composed of a steel column with steel beams at two floor levels, used highly ductile I‐shaped sections with web slenderness of either 37 or 49. Two isolated fixed‐fixed columns were tested to facilitate a direct comparison with the subassemblage testing. An axial compression force corresponding to 20% of the yield force was applied. Test results showed that the realistic boundary condition at the top end of the first‐story column significantly alters the column plastic hinging, moment distribution, and out‐of‐plane deformation reported previously based on isolated column testing. Plastic hinging of the adjoining beams caused the inflection point of the first‐story column to move upward initially, then moved downward when plastic hinging developed at the column base. Out‐of‐plane deformation observed from isolated columns did not occur in the subassemblage column because hinging did not occur at the top end. Plastic components of the backbone curves for both the subassemblage column and isolated column were very similar; the former delivered a larger story drift angle rotation due to a larger yield rotation, dependent on the elastic lateral stiffness of the column. A closed‐form solution that calculates this stiffness for any boundary condition was developed and verified from test results.
Optimization of the numerical treatment of the Darcy–Forchheimer flow of Ree–Eyring fluid with chemical reaction by using artificial neural networks
Authors: Shafiq Anum , Çolak Andaç Batur , Sindhu Tabassum Naz 
Published: September 2022

AbstractIn this study, Darcy Forchheimer flow paradigm, which is a useful paradigm in fields such as petroleum engineering where high flow velocity effects are common, has been analyzed with artificial intelligence approach. In this context, first of all, Darcy–Forchheimer flow of Ree–Eyring fluid along a permeable stretching surface with convective boundary conditions has been examined and heat and mass transfer mechanisms have been investigated by including the effect of chemical process, heat generation/absorption, and activation energy. Cattaneo–Christov heat flux model has been used to analyze heat transfer properties. Within the scope of optimizing Darcy–Forchheimer flow of Ree–Eyring fluid; three different artificial neural network models have been developed to predict Nusselt number, Sherwood number, and skin friction coefficient values. The developed artificial neural network model has been able to predict Nusselt number, Sherwood number, and skin friction coefficient values with high accuracy. The findings obtained as a result of the study showed that artificial neural networks are an ideal tool that can be used to model Darcy–Forchheimer Ree–Eyring fluid flow towards a permeable stretch layer with activation energy and a convective boundary condition.
Metastatic sporadic paraganglioma with EWSR1::CREM gene fusion: A unique molecular profile that expands the phenotypic diversity of the molecular landscape of the EWSR1::CREM gene fusion positive tumors
Authors: Javaid Sehrish , Patton Ashley , Tinoco Gabriel , Oghumu Steve , Iwenofu Obiajulu Hans 
Published: September 2022

AbstractChromosomal translocations with gene fusions are uniquely rare events in paraganglioma, mostly involving UBTF::MAML3 gene fusion. Precedent literature suggests that tumors involving MAML3 gene fusion correlate with poor clinical outcomes. Herein, we report a case of metastatic sporadic paraganglioma harboring EWSR1::CREM gene fusion in a 36‐year‐old male, that has not been previously described. The patient presented with large paraspinal mass that was resected the same year. Tumor recurred 3‐years later and on further work‐up, patient was found to have metastases involving both lungs. Histopathologic evaluation of the original primary tumor showed tightly packed irregular nests and cords of cells containing palely eosinophilic cytoplasm. Features considered atypical included: areas of solid growth pattern, coagulative tumor necrosis, focal cellular atypia and angiolymphatic invasion were also identified. By immunohistochemistry, the tumor cells were positive for synaptophysin and chromogranin and negative for keratin. The S100 stain highlights the sustentacular cells and the Ki‐67 proliferation index of 15%. The recurrence specimen was similar but showed increased cellularity, atypia, necrosis, and proliferative activity (Ki‐67 proliferation index of 35%). CT guided biopsy of the right lung lesion was consistent with metastasis. Next generation sequencing identified EWSR1::CREM fusion. The breakpoints were found in chromosome 22: 29683123 for EWSR1 exon 7 (NM_005243.3) and at chromosome 10:35495823 for CREM exon 6 (NM_001267562.1). Fluorescence in situ hybridization for EWSR1 gene rearrangement was positive. In summary, we report a case of metastatic paraganglioma with EWSR1::CREM gene fusion, not previously described in this entity, and expands on the phenotypic diversity within the genetic landscape of EWSR1::CREM gene fusion positive tumors.
Preclinical feasibility of robot‐assisted sentinel lymph node biopsy using multi‐modality magnetic and fluorescence guidance in the head and neck
Authors: Krishnan Giri , Cousins Aidan , Pham Nguyen , Milanova Valentina , Nelson Melanie , Krishnan Shridhar , van den Berg Nynke S. , Shetty Anil , Rosenthal Eben L. , Wormald Peter‐John , Thierry Benjamin , Foreman Andrew , Krishnan Suren 
Published: September 2022

AbstractBackgroundSentinel lymph node biopsy (SLNB) is a staging procedure dependent on accurate mapping of draining lymphatics via tracers. Robot‐assisted SLNB enables access to multiple neck levels with a single incision and intraoperative fluorescence guidance to the SLN.MethodsLymphatic mapping in swine was done using a magnetic tracer and fluorescent dye, injected into the tongue. MRI preoperatively mapped lymphatic spread of the magnetic tracer. Dissection was performed using a da Vinci Xi robot guided by fluorescence‐imaging of the dye.ResultsRobot‐assisted SLNB was successfully performed in all animals (n = 5). A novel MRI protocol differentiated SLNs (n = 6) from lower echelon nodes (n = 11) based on flow progression. Fluorescence imaging provided valuable intraoperative guidance and correlated with magnetic‐positive nodes.ConclusionsThis study demonstrates preclinical feasibility of a robot‐assisted approach to SLNB using magnetic and fluorescent tracers in the head and neck, enabling both preoperative mapping and intraoperative guidance.
Epidemiology and treatment outcomes of cutaneous squamous cell carcinoma extending to the temporal bone
Authors: Schachtel Michael J. C. , Gandhi Mitesh , Bowman James J. , Porceddu Sandro V. , Panizza Benedict J. 
Published: September 2022

AbstractBackgroundAccurate epidemiological and outcomes data regarding cutaneous squamous cell carcinoma (cSCC) extending to the temporal bone is lacking.MethodsRetrospective analysis of 167 Australian patients with primary and peri‐temporal bone cSCC.ResultscSCC extending from secondary subsites (93.4%) was 14 times more frequent than primary temporal bone SCC (6.6%). For patients who underwent curative surgery ± post‐operative radiotherapy (n = 146, 87.4%), 5‐year disease‐free survival, locoregional recurrence‐free survival, disease‐specific survival, and overall survival was 53.0%, 59.4%, 67.9%, and 44.7%, respectively. External ear and pre‐auricular tumors, salvage surgery, tumor size (≥40 mm medial‐lateral), nodal disease, and involved margins were negative predictors of survival in multivariable analysis.ConclusionIn regions of high sun exposure, cSCCs extending to the temporal bone are more common than primary cancers. Outcomes are improved with clear margins, justifying the need for radical resection. Further research regarding pre‐auricular cancers is required given poorer associated survival outcomes.
Emerging role of oncogenic long noncoding RNA as cancer biomarkers
Authors: Aprile Marianna , Costa Valerio , Cimmino Amelia , Calin George Adrian 
Published: September 2022

AbstractThe view of long noncoding RNAs as nonfunctional “garbage” has been definitely outdated by the large body of evidence indicating this class of ncRNAs as “golden junk”, especially in precision oncology. Indeed, in light of their oncogenic role and the higher expression in multiple cancer types compared with paired adjacent tissues, the clinical interest for lncRNAs as diagnostic and/or prognostic biomarkers has been rapidly increasing. The emergence of large‐scale sequencing technologies, their subsequent diffusion even in small research and clinical centers, the technological advances for the detection of low‐copy lncRNAs in body fluids, coupled to the huge reduction of operating costs, have nowadays made possible to rapidly and comprehensively profile them in multiple tumors and large cohorts. In this review, we first summarize some relevant data about the oncogenic role of well‐studied lncRNAs having a clinical relevance. Then, we focus on the description of their potential use as diagnostic/prognostic biomarkers, including an updated overview about licensed patents or clinical trials on lncRNAs in oncology.
Approach to urethral obstruction in cats. Part 1: presentation and stabilisation
Authors: Breheny Craig , Blacklock Kelly Bowlt , Gunn‐Moore Danièlle 
Published: September 2022

Background:Urethral obstruction is one of the most commonly encountered emergencies in feline medicine, with a wide range of clinical signs, from dysuria to peri‐arrest. Such patients are some of the most challenging cases in feline medicine with several factors to consider; however, they can be equally rewarding.Aim of the article:This is the first article in a three‐part series. The aim of this article is to summarise a stepwise approach from presentation through to diagnosis of urethral obstruction. The second article will focus on urethral catheterisation, and immediate postcatheterisation management, while the third will focus on home management to prevent recurrent obstruction, and on addressing underlying feline idiopathic cystitis.
Thyroid Dysfunction in Non‐Small Cell Lung Cancer With Immune Checkpoint Inhibitors: A Meta‐Analysis
Authors: Lin Lanlan , Yang Fan , Lin Guofu , Chen Xiangqi 
Published: September 2022

AbstractImmune
checkpoint inhibitors (ICIs) have been established as the cornerstone for advanced non‐small cell lung cancer, while thyroid adverse events (AEs) associated with ICIs have not been systematically documented. Therefore, we performed a meta‐analysis to evaluate the effect of ICI applications on the thyroid of patients with non‐small cell lung cancer. We performed a systematic search of PubMed, the Cochrane Library, Web of Science, and Embase for eligible randomized controlled trials up to December 2021. Clinical trials reporting thyroid AEs including hypothyroidism, hyperthyroidism, and thyroiditis were enrolled. The I2 statistic was also calculated to quantify the heterogeneity. Data were evaluated as risk ratio (RR) and corresponding 95%CIs. A total of 10 randomized clinical trials involving 6154 patients were included in this meta‐analysis. ICI application was found to have a statistically significant higher risk of all grade hypothyroidism (RR, 7.03; P < 0.0001), hyperthyroidism (RR, 4.88; P < 0.0001), and thyroiditis (RR, 6.58; P = 0.0014) compared with the chemotherapy group. Moreover, we demonstrated that second‐line therapy significantly increased the risk of all‐grade hypothyroidism (RR, 7.03 [95%CI, 4.69–10.55]) and hyperthyroidism (RR, 4.88 [95%CI, 3.11–7.65]). Our meta‐analysis manifested that regimens with ICIs may significantly increase all grades of hypothyroidism, hyperthyroidism, and thyroiditis. ICIs may induce the occurrence and exacerbation of endocrine AEs compared with chemotherapy.
Formation of anti‐Bredt‐type azabicyclo[4.2.0]octene frameworks through photochemical intramolecular [2+2] cycloaddition between indole and a distal double bond of allene
Authors: Arai Noriyoshi 
Published: September 2022

AbstractIrradiation of 1‐(penta‐3,4‐dienoyl)indole derivatives in the presence of an aromatic ketone by a high‐pressure mercury lamp through Pyrex glass gave two types of cyclized products stereoselectively in high combined yields. The major product was a tetracyclic indoline derivative containing anti‐Bredt‐type azabicyclo[4.2.0]octene moiety produced via photo [2+2] cycloaddition between indole and a distal double bond of allene, accompanied by a small amount of proximal [2+2] adduct. Among a range of aromatic ketones screened, 3′,4′‐methylenedioxyacetophenone was found to sensitize the substrate most effectively.
Investigation of Ultrasound Parameters for the Differential Diagnosis of Malignant and Benign Peripheral Nerve Sheath Tumors
Authors: Jin Zhenzhen , Zhao Kaiping , Guo Wen , Wang Dandan , Deng Yukun , Chen Tao 
Published: September 2022

ObjectivesThe objectives were to identify the key features of malignant and benign peripheral nerve sheath tumors (PNSTs) and determine a strategy for differentiating them using sonography.MethodsForty‐six malignant peripheral nerve sheath tumors (MPNSTs) and 83 benign peripheral nerve sheath tumors (BPNSTs) confirmed by pathology from April 2010 to July 2021 were included. The general data and grayscale and color Doppler ultrasonic manifestations were compared between the two groups. We used single factor, multifactor, and area under the receiver operating characteristic (ROC) curve analyses to extract significant malignant risk factors and then established a scoring system with these factors.ResultsThe significant variables identified in univariate analysis (P < .05) were maximum diameter, location, shape, boundary, encapsulation, echogenicity, texture pattern, calcification, entering or exiting nerve, and vascularity. Shape, boundary and vascularity were significant risk factors, and a scoring system was established. The area under the ROC curve (0.925) confirmed the usefulness of the scoring system for differentiating MPNSTs and BPNSTs.ConclusionsUltrasonography is an effective method for differentiating MPNSTs from BPNSTs.
Climate, habitat interactions, and mule deer resource selection on winter landscapes
Authors: Anton Colby B. , DeCesare Nicholas J. , Peterson Collin , Hayes Teagan A. , Bishop Chad J. 
Published: September 2022

AbstractMule deer (Odocoileus hemionus) are a valued game species across their range in North America. At higher latitudes mule deer inhabit the Northern Forests ecoregion, where the winter season poses challenging conditions. We studied resource selection during winter by mule deer in northwest Montana, USA, focused on the effects of snow and canopy cover on deer behavior. Specifically, we assessed the effects of land cover type, terrain characteristics, snow accumulation, percent canopy cover, solar radiation, and forage biomass on resource selection by 126 mule deer captured during 2017–2019 in 3 partially migratory subpopulations. We collected pellet samples and conducted diet analyses to assess forage species by individual and study area. Deer displayed a shift from nitrogen‐rich forbs and shrubs in summer to nutrient‐poor evergreens like conifers in winter. Deer avoided areas with deeper snow and sought more closed canopy forests for their snow‐intercept advantages. Weather and vegetative variation among and within study areas resulted in disparities in selection for attributes such as land cover. Similarly, mule deer diets varied spatiotemporally as a function of snow, with some deer favoring coniferous species in deep snow, whereas others less constrained by snow had more diverse diets with more shrub species. Additional analyses revealed annual individual survival correlated with changes in snow depth, suggesting fitness consequences as snow accumulated. These differences suggest locally adapted behaviors as mule deer reflect energetic constraints of winter landscapes.