bluuebunny/crossref_metadata_2025_split huggingface dataset:
β-Hydroxylation of α-amino-β-hydroxylbutanoyl-glycyluridine catalyzed by a nonheme hydroxylase ensures the maturation of caprazamycin
Authors: Zadeh Saeid Malek , Chen Mei-Hua , Wang Zhe-Chong , Astani Elahe K. , Lo I-Wen , Lin Kuan-Hung , Hsu Ning-Shian , Adhikari Kamal , Lyu Syue-Yi , Tsai Hsin-Ying , Terasawa Yuma , Yabe Miyuki , Yamamoto Kazuki , Ichikawa Satoshi , Li Tsung-Lin 
Published: July 2022

AbstractCaprazamycin is a nucleoside antibiotic that inhibits phospho-N-acetylmuramyl-pentapeptide translocase (MraY). The biosynthesis of nucleoside antibiotics has been studied but is still far from completion. The present study characterized enzymes Cpz10, Cpz15, Cpz27, Mur17, Mur23 out of caprazamycin/muraymycin biosynthetic gene cluster, particularly the nonheme αKG-dependent enzyme Cpz10. Cpz15 is a β-hydroxylase converting uridine mono-phosphate to uridine 5′ aldehyde, then incorporating with threonine by Mur17 (Cpz14) to form 5′-C-glycyluridine. Cpz10 hydroxylates synthetic 11 to 12 in vitro. Major product 13 derived from mutant Δcpz10 is phosphorylated by Cpz27. β-Hydroxylation of 11 by Cpz10 permits the maturation of caprazamycin, but decarboxylation of 11 by Mur23 oriented to muraymycin formation. Cpz10 recruits two iron atoms to activate dioxygen with regio-/stereo-specificity and commit electron/charge transfer, respectively. The chemo-physical interrogations should greatly advance our understanding of caprazamycin biosynthesis, which is conducive to pathway/protein engineering for developing more effective nucleoside antibiotics.
Dual-modality fibre optic probe for simultaneous ablation and ultrasound imaging
Authors: Zhang Shaoyan , Zhang Edward Z. , Beard Paul C. , Desjardins Adrien E. , Colchester Richard J. 
Published: July 2022

AbstractAll-optical ultrasound (OpUS) is an emerging high resolution imaging paradigm utilising optical fibres. This allows both therapeutic and imaging modalities to be integrated into devices with dimensions small enough for minimally invasive surgical applications. Here we report a dual-modality fibre optic probe that synchronously performs laser ablation and real-time all-optical ultrasound imaging for ablation monitoring. The device comprises three optical fibres: one each for transmission and reception of ultrasound, and one for the delivery of laser light for ablation. The total device diameter is < 1 mm. Ablation monitoring was carried out on porcine liver and heart tissue ex vivo with ablation depth tracked using all-optical M-mode ultrasound imaging and lesion boundary identification using a segmentation algorithm. Ablation depths up to 2.1 mm were visualised with a good correspondence between the ultrasound depth measurements and visual inspection of the lesions using stereomicroscopy. This work demonstrates the potential for OpUS probes to guide minimally invasive ablation procedures in real time.
“Electromagnetic barrier” assisted dynamic spectrum access in satellite internet communication confrontation
Authors: Yan Peijie , Chu Feihuang , Jia Luliang , Qi Nan 
Published: July 2022

AbstractIn this paper, the dynamic spectrum access is investigated in satellite internet. Firstly, to describe the confrontation characteristics of the electromagnetic environment, two opposing teams denoted as the blue team (BT) and red team (RT), are designed. In addition, an “electromagnetic barrier” jamming strategy is proposed to achieve the effect of promoting approach defence with the attack. Precisely, the “electromagnetic barrier” can significantly weaken the communication ability of enemies (i.e. RT) while protecting the (i.e. BT) communication quality. Secondly, internal interference, external interference and malicious jamming of BT and RT are considered, and expected weighted aggregate interference and jamming (EWAIJ) are introduced to integrate these interference. Moreover, minimising interference is taken as the optimisation goal. Thirdly, Game theory is introduced to describe the combinatorial optimisation problem. The process of each team finding the optimal spectrum access strategy is proved to be an exact potential energy game. These two sub‐games together constitute the Stackelberg game framework. Finally, a distributed hierarchical confrontation channel selection algorithm (DHCCSA) is proposed to find the Stackelberg equilibrium solution. The simulation results show that the proposed algorithm can converge to a better effect compared with other algorithms. In addition, with the assistance of the “electromagnetic barrier,” BT is more robust than RT in terms of convergence rate, total utility, and total network throughput.
Coordination optimisation of energy and manufacturing flow for industry integrated energy system
Authors: Liu Kun , Gao Feng 
Published: July 2022

AbstractWith the breaking down of information barriers between energy flow with manufacturing flow, the coordination between them is an effective way to relieve the dual pressure from energy and environment industrial integrated energy system. The authors develop a scenario‐based coordination model for energy flow and manufacturing flow to make full use of the flexibilities of energy supply and production process to reduce energy cost. To capture the flexibility in the energy flow, the authors enhance an electricity‐steam‐product gas–gas storage coupling energy flow model considering multi‐uncertainties. The authors also develop a batch process model to formulate the flexibility in the production process. Based on the batch energy consumption constraints, the energy flow model and the batch process model are integrated as a coordination model. To ensure the feasibility of hard budget constraints under all possible random realisations, we add all‐scenario‐feasibility robust constraints which are infinite‐dimensional constraints into the model. To solve the model, a vertex scenario set based on the characteristics of convex optimisation is constructed to equivalently convert infinite‐dimensional constraints to finite‐dimensional constraints. In this way, the coordination model is transformed to a mixed integer linear programming and can be solved using CPLEX. Finally, numerical test based on a real iron and steel plant is analysed. The results show that coordination between energy with manufacturing flow is effective to reduce the energy cost and carbon emission. Compare with only optimising energy flow, the coordination model can reduce total cost about 221.6 thousand RMB and 304.44t coal every day.
Modelling multiple quantiles together with the mean based on SA‐ConvLSTM for taxi pick‐up prediction
Authors: Chen Qixiang , Lv Bin , Hao Binbin , Luo Weizhuang , Lang Binke , Li Xu 
Published: July 2022

AbstractA more complete taxi pick‐ups prediction going beyond the conditional expectation would be more beneficial to allocate taxis effectively. Prior works have predicted the conditional expectation of taxi demand and improved the prediction accuracy. But the ability to convey calibrated uncertainty estimates in prediction was less studied. Here, a multi‐output multi‐quantile deep neural network architecture is presented for predicting the mean and the multiple quantiles simultaneously, which jointly models multiple quantiles together with the conditional expectation based on self‐attention ConvLSTM. Using the NYC taxi dataset, we have analyzed the performance of the developed architecture. For the mean prediction, the proposed method has an error of 8.584 in terms of RMSE criteria and Linear QR, Mcdropout‐Gal, ConvLSTM and SA‐ConvLSTM methods, which have error values of 8.800, 8.671, 8.599, and 8.597, respectively. According to the MAE criterion, this method has a value of 5.934. The other methods have obtained values of 6.614, 5.990, 5.986, and 5.959, respectively. For multiple quantiles prediction, the proposed method produces narrower intervals while obtaining the target coverage percentage. Overall, the proposed model not only outperforms the other models, but also provides a rich description about the predictive density.
Joint optimization combining the capacity of subway on‐board energy storage device and timetable
Authors: Wang Xiaowen , Sun Pengfei , Wang Qingyuan , Ding Juxia , Feng Xiaoyun 
Published: July 2022

AbstractOn‐board energy storage devices (OESD) and energy‐efficient train timetabling (EETT) are considered two effective ways to improve the usage rate of regenerative braking energy (RBE) of subway trains. EETT is less costly but has lower ceilings, whereas OESD, although expensive, maximizes the reuse of RBE. To make the RBE usage rate of the train group reach the required target, a typical problem is how to use the OESD with the minimum capacity to reduce the cost. With this consideration, this paper proposes an optimization method that combines EETT and OESD. In this method, the joint optimization of timetable and OESD capacity allocation in case OESDs of different capacities can be carried between trains is considered to further improve the optimization. A non‐linear programming model is built to minimize the total OESD capacity of the train group under the constraint of reaching target RBE usage. An efficient heuristic algorithm is designed to simultaneously obtain the optimal timetable and the matching capacity allocation scheme of OESDs. Finally, some simulation cases based on real‐line data are designed to verify the effectiveness of the method.
The Tarantula Massive Binary Monitoring
Authors: Shenar T. , Sana H. , Mahy L. , Maíz Apellániz J. , Crowther Paul A. , Gromadzki M. , Herrero A. , Langer N. , Marchant P. , Schneider F. R. N. , Sen K. , Soszyński I. , Toonen S. 
Published: July 2022

Context. Massive binaries hosting a black hole (OB+BH) represent a critical phase in the production of BH mergers in the context of binary evolution. In spite of this, such systems have so far largely avoided detection. Single-lined spectroscopic (SB1) O-type binaries are ideal objects to search for elusive BH companions. Moreover, SB1 binaries hosting two main sequence stars probe a regime of more extreme mass ratios and longer periods compared to double-lined binaries (SB2), and they are thus valuable for establishing the natal mass ratio distribution of massive stars.
Aims. We characterise the hidden companions in 51 SB1 O-type and evolved B-type binaries identified in the Large Magellanic Cloud (LMC) in the framework of the VLT-FLAMES Tarantula Survey (VFTS) and its follow-up, the Tarantula Massive Binary Monitoring (TMBM). The binaries cover periods between a few days to years (0 < log P < 3 [d]). Our goals are to hunt for BHs and sample the low-mass end of the mass-ratio distribution.
Methods. To uncover the hidden companions, we implemented the shift-and-add grid disentangling algorithm using 32 epochs of spectroscopy acquired in the framework of TMBM with the FLAMES spectrograph, allowing us to detect companions contributing as little as ≈1–2% to the visual flux. We further analysed OGLE photometric data for the presence of eclipses or ellipsoidal variations.
Results. Out of the 51 SB1 systems, 43 (84%) are found to have non-degenerate stellar companions, of which 28 are confident detections and 15 are less certain (SB1: or SB2:). Of these 43 targets, one is found to be a triple (VFTS 64), and two are found to be quadruples (VFTS 120, 702). Our sample includes a total of eight eclipsing binaries. The remaining eight targets (16%) retain an SB1 classification. We modelled the mass-ratio distribution as f (q) ∝ qκ, and derived k through a Bayesian approach. We used massratio constraints from previously known SB2 binaries, newly uncovered SB2 binaries, and SB1 binaries, while accounting for binary detection bias. We found k = 0.2 ± 0.2 for the entire sample and κ = −0.2 ± 0.2 when excluding binaries with periods shorter than 10 d. In contrast, k = 1.2 ± 0.5 was retrieved for tight binaries (P < 10 d), and it is proposed here to be a consequence of binary interactions. Aside from the unambiguous O+BH binary VFTS 243, which was analysed in detail in a separate paper, we identified two additional OB+BH candidates: VFTS 514 and 779.
Conclusions. Our study firmly establishes a virtually flat natal mass-ratio distribution (κ = 0) for O-type stars at LMC metallicity, covering the entire mass-ratio range (0.05 < q < 1) and periods in the range 0 < log P < 3 [d]. The nature of the OB+BH candidates should be verified through future monitoring, but the frequency of OB+BH candidates is generally in line with recent predictions at LMC metallicity.
Infestation of chigger mites on Chinese mole shrew,Anourosorex squamipes, in Southwest China and ecological analysis
Authors: Li Bei , Guo Xian-Guo , Zhao Cheng-Fu , Zhang Zhi-Wei , Fan Rong , Peng Pei-Ying , Song Wen-Yu , Ren Tian-Guang , Zhang Lei , Qian Ti-Jun 
Published: July 2022

The Chinese mole shrew,Anourosorex squamipesMilne-Edwards, 1872, is a common species of insectivorous mammal in Southwest China. Based on field investigations between 2001 and 2019, the present study reports the infestation of chiggers (larvae of chigger mites) on the shrew in Southwest China and certain ecology parameters for the first time. A total of 3169 chiggers were collected from 1694A. squamipesand they were identified into 72 species and 10 genera in the family Trombiculidae. The overall infestation prevalence (Pm), mean abundance (MA) and mean intensity (MI) ofA. squamipeswith chiggers reached 11.1%, 1.87 and 16.86, respectively. The species diversity, species composition and infestation of chiggers onA. squamipesfluctuated in different environments (latitudes, altitudes, habitats and landscapes) and on different sexes and ages of the shrew hosts with high heterogeneity and low species similarity. In the established linear regression equation (M* = 0.173 + 1.054 M) for dominant miteLeptotrombidium densipunctatum, both theαandβvalues (α = 0.173,β = 1.054) exceeded the boundary values (F = 4.67,p < 0.05), and therefore the spatial distribution pattern of this mite was determined as an aggregated distribution among different individuals of shrew hosts. The species abundance distribution of the chigger community onA. squamipesconformed to the lognormal distribution, and its curve showed a gradually descending tendency from the rare mite species to the dominant mite species. The curve tendency of species-sample relationship implies that more species of chiggers would be found if the host samples infinitely keep increasing.
Versorgung kritisch kranker Patienten in der zentralen Notaufnahme
Authors: Michael Mark , Kumle Bernhard , Kümpers Philipp , Bernhard Michael 
Published: July 2022

AbstractResuscitation room management of non-traumatic critically ill patients in the emergency department comprises approximately 1.5% of all emergency department visits. Critically ill patients
are usually brought to the hospital by emergency medical services, where they are first examined, given initial treatment, stabilized and then transported for further in-hospital treatment.
Resuscitation room management plays a key role at the interface of the out-of-hospital and in-hospital treatment chains. While the structured care of traumatological patients has been
established at a very high level for decades, the care of non-traumatic critically ill patients within the framework of resuscitation room care has only come into focus in recent years and
is only now being implemented in some places with professional concepts. Emergency departments at all levels of care are equipped to provide structured care for non-traumatologic shock room
patients. To professionalize non-traumatic resuscitation room management, the creation of uniform standards from alerting criteria, to equipment and staffing, as well as the establishment of
a uniform resuscitation room management algorithm is required. The (PRE_E-)AUD2IT-algorithm provides a structure for the non-traumatic care of critically ill patients in the
resuscitation room and includes preparation, resource retrieval, handover, initial care, diagnostics, differential diagnoses and the interpretation of examination findings. This overview
focuses on the management of critically ill non-traumatic patients in respect to the resuscitation room care concept.
Steigerung der Therapietreue durch niederschwellige Kontakte
Authors: Lang Michael , Cepek Lukas , Rau Daniela , Denkinger Nadine , Behrens Katja , Kornhuber Anselm 
Published: July 2022

ZUSAMMENFASSUNGBesonders bei Menschen mit chronischen Erkrankungen, z. B. Multiple Sklerose (MS), stellt die Einhaltung der verordneten Therapie über einen langen Zeitraum eine große Herausforderung dar. Teils alarmierend niedrige Adhärenzraten und ein dadurch geringerer Therapienutzen sind die Folge. Neben einem verbesserten Nebenwirkungsmanagement haben sich Vertrauen in die Therapie und wahrgenommenes Engagement des Arztes als modifizierbare positive Einflussgrößen auf die Adhärenz herausgestellt. Die nötige umfassende Betreuung der Patienten über Jahre hinweg kann dabei nicht allein durch den Arzt bewältigt werden, sondern bedarf idealerweise der Unterstützung durch Patientenprogramme und speziell ausgebildeter MS-Schwestern (Nurses), die dem Patienten eine unkomplizierte Kontaktaufnahme zur Besprechung von Sorgen oder Fragen unabhängig von Arztterminen ermöglicht. Diese niederschwelligen Kontakte konnten als signifikanter Faktor identifiziert werden, der über die Therapietreue entscheiden kann. Zusätzlich haben in den letzten Jahren digitale Anwendungen wie Apps bei langen und unvorhersehbaren Krankheitsverläufen wie bei der MS an Bedeutung gewonnen und können ohne Belastung des ärztlichen Zeitbudgets als smarte Therapiebegleiter fungieren.
Linkage of Young Mania Rating Scale to Clinical Global Impression
Scale to Enhance Utility in Clinical Practice and Research
Trials
Authors: Samara Myrto T. , Levine Stephen Z. , Leucht Stefan 
Published: July 2022

Abstract
Introduction The Young Mania Rating Scale (YMRS) is the gold standard to
assess manic symptoms of bipolar disorder, yet the clinical meaning of scores is
unknown. To clinically understand and interpret YMRS scores, we examined
linkages between the total and change scores of YMRS with the Clinical Global
Impression (CGI) ratings.
Methods Individual participant data (N=2,988) from eight
randomized, double-blind, placebo-controlled trials were included. Data were
collected at baseline and subsequent visits. Spearman’s correlation
coefficients ρ were computed, and equipercentile linking was
implemented.
Results A YMRS score of 6 points corresponded approximately to
‘borderline mentally ill,’ 12 points to ‘mildly
ill,’ 20 points to ‘moderately ill,’ 30 points to
‘markedly ill,’ 40 points to ‘severely ill,’ and
52 points to ‘among the most extremely ill’ patients on the
CGI-S. A reduction of CGI-S by one point as well as ‘minimally
improved’ on the CGI-I corresponded approximately to an absolute
decrease of 4 to 8 YMRS points or a 21% to 29% reduction of YMRS
baseline score whereas a reduction of CGI-S by two points and ‘much
improved’ on the CGI-I corresponded to an absolute decrease of 10 to 15
points or a 42% to 53% reduction of YMRS baseline score.
Discussion The current study findings offer clinicians meaningful cutoff
values to interpret YMRS scores. Moreover, these values contribute to the
definition of treatment targets, response, remission, and entry criteria in
mania trials.
Epileptischer Anfall bei älteren Patienten
Authors: Heckelmann Jan , Weber Yvonne 
Published: July 2022

ZUSAMMENFASSUNGDie Inzidenz vorübergehender Bewusstseinsverluste steigt mit zunehmendem Alter an, dies gilt jedoch sowohl für Anfälle epileptischer Genese als auch für Bewusstseinsverluste nicht epileptischer Natur, insbesondere aus kardialer oder zerebrovaskulärer Ursache. Zur sicheren Differenzierung ist daher primär eine umfassende Anamnese sowohl der Semiologie des Ereignisses als auch möglicher Auslösefaktoren zu erheben und, je nach Ergebnis, eine gezielte apparative Diagnostik durchzuführen. Bei Diagnose einer Epilepsie muss im Rahmen der Therapie beachtet werden, dass im Alter aufgrund einer veränderten Pharmakodynamik und vielfacher Wechselwirkungen, eine medikamentöse Therapie oftmals durch nicht akzeptable unerwünschte Arzneimittelwirkungen erschwert wird. Weitere Therapiemöglichkeiten sind auch im höheren Lebensalter zu erwägen, wie die verschiedenen Möglichkeiten der Epilepsiechirurgie.
Verruca Vulgaris Treated with Constitutional Homoeopathic Remedy—Case Report
Authors: Bhandary Apeksha 
Published: July 2022

Abstract
Background Verruca vulgaris popularly known as common warts is non-cancerous skin growth, caused by the human papilloma virus. Homoeopathic treatment of warts is largely through constitutional medicine. Although verruca vulgaris is not a life-threatening disease, it does take a toll on one's confidence. Some variants do cause pain apart from visibly affecting mental health if not treated properly; patients with weakened immune systems can have major problems with warts. This is a case of 20-year-old female who had multiple lesions of painful verruca vulgaris treated with homoeopathic constitutional remedy Natrum muriaticum (Nat-m).
Methods At a Homoeopathy Institute in Mangalore, India, a 20-year-old female student with verruca vulgaris was treated solely with homoeopathic constitutional remedy. During follow-up visits, outcome was assessed as to whether the documented changes were likely to be associated with homoeopathic intervention; an assessment using the modiﬁed Naranjo criteria was performed.
Result Over an observation period of 5 months, a beneﬁcial result from Nat-m was noted for verruca vulgaris.
Conclusion In cases like verruca vulgaris, considering its inevitability of recurrence with conventional therapy, a therapeutic approach that integrates the totality of symptoms and complaints of a patient might be of value.
Rare Association of Tuberous sclerosis with Acute Lymphoblastic Leukemia: Case Report with Review of Literature
Authors: Sampagar Abhilasha , Chakrala Rajkumar , Kamate Mahesh 
Published: July 2022

AbstractAcute lymphoblastic leukemia (ALL) is the most common leukemia in children in which 85% of all cases are of B-cell ALL and approximately 15% cases are of T-cell ALL (T-ALL). Recent revolution in next-generation sequencing has uncovered many novel somatic mutations and rearrangements in ALL cells, which have prognostic and therapeutic implications, and it has also led to recognition of germline variants in the same genes with somatic mutations commonly associated with ALL. Apart from increasing the risk of developing ALL, germline variants may influence diagnostic testing, genetic counseling, and response to antileukemic treatment. This emphasizes importance of identification of new germline variants, or association of inherited syndromes with ALL or other malignancies. Down's syndrome, Shwachman's syndrome, Fanconi anemia, Bloom's syndrome, neurofibromatosis, and ataxia telangiectasia are well-recognized conditions associated with ALL. In this communication, we report a rare association of T-ALL with tuberous sclerosis (TS). This is the first reported case, showing association of T cell leukemia and TS with confirmatory genetic work-up.