bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple Stress Creep Recovery Test to Differentiate Polymer Modified Bitumen at High Temperature
Authors: Porot Laurent , Zhu Jiqing , Wang Di , Cannone Falchetto Augusto 
Published: November 2022

Abstract
The constant demand for high-performing and more reliable roads has led to an increasing use of complex bituminous binders such as polymer-modified bituminous binders, which has become a widespread practice for asphalt pavement. As a result, specification and testing have evolved to better distinguish between quality materials. In recent years, more focus has been devoted to better evaluating the rutting resistance of bituminous binders. The multiple stress creep recovery (MSCR) test has gained popularity over the last decade, especially for polymer-modified binders, bringing more advantages in discriminating amongst quality binders such as polymer-modified bitumen. Within the International Union of Laboratories and Experts in Construction Materials, Systems and Structures technical committee 272, Phase and Interphase of Behavior of Innovative bituminous Materials, and its TG1 task group, several binders were thoroughly evaluated, including two non-modified and two polymer-modified bituminous binders, under various testing conditions to address the high-temperature behavior. Five laboratories performed MSCR on short-term aged binders after performing the rolling thin film oven test, in the same temperature conditions for all binders. Despite the limited data set, the variability between laboratories was reasonable. The MSCR results were compared with softening point temperature, high-temperature performance grade criteria, |G*| / sinδ, and equi-modulus temperature. MSCR was able to distinguish between complex binders better as compared with conventional parameters. It generates multiple useful parameters, amongst which percent recovery and non-recoverable creep compliance are the most relevant. This paper presents the analysis of MSCR results and comparison with other test methods.
Interpretation of Site-Specific Reliability Index for Piles Using Multiple Bidirectional Tests
Authors: Wu Xing Zheng , Chen Yu , Fang Ke Zhao 
Published: November 2022

Abstract
The Osterberg cell test is an effective tool to evaluate the bearing behavior for piled foundations. Because of the significant intrinsic variabilities in material properties of piles, soil-pile intermediate, and soils, the responses of multiple piles under loading are uncertain. These uncertainties should be considered to evaluate the bearing characteristics of piles, in this work, a methodology for estimating the geometric reliability index of piles using the Osterberg cell testing is proposed. A dataset of load−displacement curves including 26 Osterberg cell-tested drilled shafts at the Los Angeles Memorial Coliseum site is used to illustrate the proposed method. Regression analyses with a two-parametric power law curve-fitting model are firstly used to construct the best-fit model for each load-displacement curve along an upward or downward direction individually. As a result, the regression parameters for this site are combined into a random vector. Statistical analyses are then performed on these regression variables, and the bivariate normal and non-normal models are developed. These bivariate models are used to predict the reliability index of these drilled shafts via the geometric reliability method. Such an interpretation of reliability index by analyzing the scatter in load test data can be helpful to design on pile foundations.
Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis
Authors: Kwon Hyuk‐Kwon , Yu Kristin E , Cahill Sean V , Alder Kareme D , Dussik Christopher M , Kim Sang‐Hun , Sharma Lokesh , Back Jungho , Oh Irvin , Lee Francis Y 
Published: November 2022

AbstractIntracellular infiltration of bacteria into host cells complicates medical and surgical treatment of bacterial joint infections. Unlike soft tissue infections, septic arthritis and infection‐associated inflammation destroy cartilage that does not regenerate once damaged. Herein, we show that glycolytic pathways are shared by methicillin‐resistant Staphylococcus aureus (MRSA) proliferation and host inflammatory machinery in septic arthritis. MRSA readily penetrates host cells and induces proinflammatory cascades that persist after conventional antibiotic treatment. The glycolysis‐targeting drug dimethyl fumarate (DMF) showed both bacteriostatic and anti‐inflammatory effects by hindering the proliferation of intracellular MRSA and dampening excessive intraarticular inflammation. Combinatorial treatment with DMF and vancomycin further reduced the proliferation and re‐emergence of intracellular MRSA. Combinatorial adjuvant administration of DMF with antibiotics alleviated clinical symptoms of septic arthritis by suppressing bacterial burden and curbing inflammation to protect cartilage and bone. Our results provide mechanistic insight into the regulation of glycolysis in the context of infection and host inflammation toward development of a novel therapeutic paradigm to ameliorate joint bioburden and destruction in septic arthritis.
Trends in Prevalence of Bacterial Infections in Febrile Infants During the COVID-19 Pandemic
Authors: Aronson Paul L. , Kerns Ellen , Jennings Brittany , Magee Sloane , Wang Marie E. , McDaniel Corrie E. ,   AAP REVISE II QI COLLABORATIVE
Published: November 2022

OBJECTIVES
Our objective was to describe the prevalence of urinary tract infection (UTI) and invasive bacterial infection (IBI) in febrile infants during the coronavirus disease 2019 pandemic.

METHODS
We conducted a multicenter cross-sectional study that included 97 hospitals in the United States and Canada. We included full-term, well-appearing infants 8 to 60 days old with a temperature of ≥38°C and an emergency department visit or hospitalization at a participating site between November 1, 2020 and March 31, 2022. We used logistic regression to determine trends in the odds of an infant having UTI and IBI by study month and to determine the association of COVID-19 prevalence with the odds of an infant having UTI and IBI.

RESULTS
We included 9112 infants; 603 (6.6%) had UTI, 163 (1.8%) had bacteremia without meningitis, and 43 (0.5%) had bacterial meningitis. UTI prevalence decreased from 11.2% in November 2020 to 3.0% in January 2022. IBI prevalence was highest in February 2021 (6.1%) and decreased to 0.4% in January 2022. There was a significant downward monthly trend for odds of UTI (odds ratio [OR] 0.93; 95% confidence interval [CI]: 0.91–0.94) and IBI (OR 0.90; 95% CI: 0.87–0.93). For every 5% increase in COVID-19 prevalence in the month of presentation, the odds of an infant having UTI (OR 0.97; 95% CI: 0.96–0.98) or bacteremia without meningitis decreased (OR 0.94; 95% CI: 0.88–0.99).

CONCLUSIONS
The prevalence of UTI and IBI in eligible febrile infants decreased to previously published, prepandemic levels by early 2022. Higher monthly COVID-19 prevalence was associated with lower odds of UTI and bacteremia.
Analysing adjustment factors for using lanes at traffic-light-controlled intersections in Bogotá, Colombia
Authors: Peña Lindarte Ricardo José 
Published: November 2022

This article was focused on analysing the lane use adjustment factor (fLU) forming one of the eleven adjustment factors proposed in the current calculation methodology contained in the 2000 version of the Transportation Research Boards (TRB) Highway Capacity Manual (HCM) for analysing traffic-light-controlled intersection capacity in terms of saturation intensity. A methodology was established when analysing the fLU factor that considered operational conditions regarding traffic-light-controlled intersections in Bogota. Road traffic flows were analysed, including characterising road traffic based on statistical sampling, field data collection and analysis. The project proposed equations allowing reference values to be gathered for determining adjustment factors regarding lane use on roads in Bogota in relation to existing access typologies and road traffic volume for analysing traffic-light-controlled intersections. For example, in the specific case of roads having direct double-lane access (2CCD), the basic equation was determined to be y=-3,03E-08X2+3,44E-05X+0,888988, having a 1.0 coefficient of correlation. The dependent variable y referred to the fLU factor and the independent variable X was the volume of road traffic in mixed vehicles/hour. This equation was considered to be statistically relevant. A comparative analysis of the lane use adjustment factors estimated in the project is also presented and compared to the values recommended by the US Highway Capacity Manual. The projects conclusions and recommendations were thus sustained, validating the recommended factors summarised by the HCM and recommending that the results obtained from the project should be used in traffic-light-controlled design and planning projects.
Treating leachate by Fenton oxidation
Authors: Méndez Novelo Roger Iván , García Reyes Refugio Bernardo , Castillo Borges Elba René , Sauri Riancho María Rosa 
Published: November 2022

Leachates are formed from liquids, mainly rainwater, percolating through solid wastes during stabilisation. Their composition is variable and highly toxic; leachate treatment is therefore a complex task. Leachates represent a high risk to health due to the Yucatan Peninsulas highly permeable soil. The results are presented from applying the Fenton process to treating leachate from the sanitary Merida landfill, Yucatan, Mexico. The Fenton process consists of treating the contaminant load with an H2O2 and FeSO4 combination in acidic conditions. Optimal reaction time, pH value, Fenton reagent dose, post treatment coagulation - flocculation doses and increased biodegradability index were all determined. Optimal oxidation conditions and doses were 20 minute contact time, 4 pH, 600 mg/L H2O2 concentration and 1,000 mg/L Fe2+. Average organic matter removal rate, measured as CODS and TOC, were 78% and 87% respectively. The biodegradability index increased from 0.07 to 0.11 during the Fenton process and up to 0.13 when the Fenton process was followed by coagulation-flocculation.
Comparative performance and emission tests of a heavy duty off-highway diesel engine working in two different conditions: route test and bench test
Authors: Mantilla González Juan Miguel , Roncancio G. Jorge A. , Acevedo G Helmer R. 
Published: November 2022

Several tests were carried out on a 1,640 kW (2,200 hp) diesel engine operating in two different sets of conditions: a bench test and route test (when the engine was located on a mining truck). The engine was mounted on a dynamometer for the first set of conditions. The parameters measured were break torque, cylinder and air inlet temperatures, exhaust gas temperature and both fuel consumption and airflow. Gas emissions were also recorded. The engine operated during the first phase of the study according to a test protocol allowing real work conditions to be simulated during a typical cycle present on the operation route. Afterwards, the mining truck was instrumented for the second set of working conditions and the corresponding monitoring work was done while the truck was working on the route assigned by the trucks operator. A comparative analysis was then made of the results obtained in the two sets of working conditions. This analysis led to observing that the results obtained in the two tests had a very similar pattern and thus led to validating the results obtained in the bench test.
The consequences of heavy-tailed service time distribution on a basic queuing model and its performance indicators
Authors: Rangel Martínez Lina M. , Alvarado Valencia Jorge A. 
Published: November 2022

Recent research showing theoretical generative models for heavy-tailed service time queues and its empirical validation implies the need for a better knowledge of the key performance indicators' behaviour under such assumption. The behaviour of the average length of the queue (Lp) and the average waiting-time (Wp)were analysed through simulation, varying system capacity, average service utilisation factor (r) and the number of servers in the systems as parameters. Comparisons were also made with service times based on Poisson processes. The results showed more sensitive variations Lq and Wq heavy-tailed service times than for Poisson-based service times. Systems having a capacity of over 1,000 entities might be considered as being systems having infinity capacity and the number of servers has a greater importance in heavy-tailed ruled processes than in Poisson processes. There was a lack adequacy Lq and Wq as key performance indicators for heavy-tailed service times, leading to unexpected and unstable results.
Thermistor formation using BaTiO3 powders synthesised by the Pechini method
Authors: Fernández Perdomo Claudia P. , Rodríguez Páez Jorge E. 
Published: November 2022

Barium titanate (BaTiO3) is a compound of interest in the field of electroceramics which is widely used in the manufacture of capacitors, piezoelectric transducers and resistive devices having a positive temperature coefficient (PTCR) and in manufacturing pyroelectric and optoelectronic devices. Most of these devices are obtained by consolidating high purity, suitable sized particle ceramic powders; structured synthesis methods are required to ensure such requirements. BaTiO3 powders were synthesised by a polymeric precursor method (Pechini) in this work. Very pure, small particle sized, raw material was obtained. These powders were characterised using thermogravimetric and differential thermal analysis (TGDT), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). The results indicated that samples treated at 650°C presented cubic BaTiO3 as unique crystalline phase. If a sample were treated at 1,100°C, the tetragonal phase having a c/a < 1.007 relationship was the main crystalline phase. Samples treated at 1,100°C showed ferroelectric-paraelectric transition at T ≈ 123°C. BaTiO3 tetragonal ceramic powders were uniaxially pressed and then synthesised at 1,200°C for 2 hours. These samples were electrically characterised. These samples' curves of electrical resistance versus temperature (R-T) showed their PTCR thermistor behaviour. Current-voltage (IV) variation was also measured at different temperatures.
Two-dimensional wood drying stress simulation using control-volume mixed finite element methods (CVFEM)
Authors: Salinas Carlos , Chavez Cristian , Gatica Yerko , Ananias Rubén 
Published: November 2022

The work was aimed at simulating two-dimensional wood drying stress using the control-volume finite element method (CVFEM). Stress/strain was modeled by moisture content gradients regarding shrinkage and mechanical sorption in a cross-section of wood. CVFEM was implemented with triangular finite elements and lineal interpolation of the independent variable which were programmed in Fortran 90 language. The model was validated by contrasting results with similar ones available in the specialised literature. The present model's results came from isothermal (20ºC) drying of quaking aspen (Populus tremuloides): two-dimensional distribution of stress/strain and water content, 40, 80, 130, 190 and 260 hour drying time and evolution of normal stress ( -2,5<σxx<1,2, MPa), from the interior to the exterior of wood.
Electrodermal activity - a review
Authors: Moncada María Elena , De la Cruz Jorge 
Published: November 2022

The electricity in living tissue was widely studied around the 19th century. Such study was suspended for many years but has then been started again during recent decades. New research into bioelectricity is creating alternatives in the health field; one of them is an electrodermal response associated with the wound healing, cell stimulation and psychopathology diagnostic. This article presents some of the first responses and models concerning electrodermal activity. Theoretical, clinical and review papers were studied and classified to show the amplitude and variety of bioelectrical responses. Electrodermal activity is only one of many applications having an abundant amount of evidence regarding diagnosis and treatment starting from bioelectrical signals. Electrical tissue response requires more experimental, theoretical and clinical research in many fields involving an organism' s behaviour to ascertain, propose and create new treatment alternatives for different pathologies.
Factores asociados a la mortalidad en pacientes con COVID-19 admitidos en una Unidad de Cuidados Intensivos de Medellín, Colombia. Marzo-diciembre 2020
Authors: Ramírez-Vélez Andrés , Yepes-Gómez David , Pérez-Muñoz Marcela , Zuluaga-García Juan Pablo , Zambrano-Rico Sara , Moreno-Bedoya Sara , Barrios-Arroyave Freddy Andrés 
Published: November 2022

Introducción. La COVID-19 se manifiesta en el 80% casos de forma leve, sin embargo, en 5% progresa a enfermedad severa con necesidad de manejo en unidad de cuidados intensivos (UCI).
Objetivo. Identificar los factores demográficos, clínicos y de tratamiento asociados a la mortalidad en pacientes con COVID-19 atendidos en la UCI de un hospital de cuarto nivel de atención de Medellín, Colombia.
Materiales y métodos. Estudio de cohorte retrospectivo. Se analizaron las historias clínicas de 182 pacientes admitidos en UCI por COVID-19 entre marzo y diciembre de 2020. Se realizaron análisis bivariados (pruebas de chi-cuadrado, exacta de Fisher, t de Student no pareada o U de Mann-Whitney) para evaluar la asociación entre, por un lado, características demográficas, presencia de enfermedades coexistentes, resultados de laboratorios, intervenciones terapéuticas, requerimiento de soporte ventilatorio y hemodinámico, y, por otro, mortalidad. Además, se realizó un análisis multivariado en el que se construyeron regresiones logísticas binarias simples y múltiples, calculando RR crudos y ajustados. Se consideró un nivel de significancia de p<0.05.
Resultados. La mortalidad fue de 47.80%. En el análisis multivariado, los siguientes factores se comportaron como factores protectores: edad <60 años (RRa: 0.154, IC95%:0.059-0.401; p=0.000), uso de vasopresores (RRa 0.082, IC95%:0.021–0.319; p<0.001) y uso de terapia de remplazo renal (RRa: 0.205, IC95%:0.059–0.716; p=0.013). La no realización de traqueostomía se asoció como factor de riesgo (RRa: 14.959, IC95%:4.865-45.998; p<0.001). El conteo más bajo de plaquetas registrado durante la estancia en UCI tuvo un efecto neutro pero fue una variable cuantitativa significativamente asociada (RRa: 0.999, IC95%:0.990-0.999; p=0.003).
Conclusiones. En el presente estudio, tener menos de 60 años, el uso de vasopresores y de terapia de remplazo renal se comportaron como factores protectores, mientras que la no realización de traqueostomía se comportó como factor de riesgo para mortalidad. Además, el conteo más bajo de plaquetas registrado durante la estancia en UCI fue una variable cuantitativa significativamente asociada.
Functional wafer cream fortified with carob molasses pulp flour
Authors: Özdemir Y. , Öncel B. , İlhan S. 
Published: November 2022

AbstractWafer cream is an important product used in many foods, especially confectionery products, and consumed with delight. Therefore, nutritional enrichment of this product is of great importance. In this study, a new functional product was developed by adding carob molasses pulp (CMP) flour obtained from carob fruit, which has unique nutritional and bioactive properties, to wafer cream, increasing its nutritional value and antioxidant activity. When 15% CMP flour was added to the wafer cream formulation, there was an increase of approximately 58.43 and 78.77%, respectively, in total polyphenol and antioxidant levels compared to the control group (without CMP flour). In addition, since the product developed is in cocoa colour, consumer preference has increased. It has been determined that phytochemical and nutritive components of the wafer cream increased as a result of the use of carob flour.
Hyporesponse to statin therapy among patients with acute coronary syndrome: prevalence, impact on the development of heart failure in a short-term follow-up
Authors: Druk I. V. , Korennova O. Yu. , Yukhina Yu. E. , Savchenko M. V. , Maciyauskas N. A. , Shukil L. V. 
Published: November 2022

Aim. To study the prevalence of hyporesponse to statin therapy and its impact on the development of heart failure (HF) among patients after acute coronary syndrome (ACS) in a short-term follow-up.Material and methods. This retrospective analysis of outpatient medical records of 400 patients observed at the Omsk Clinical Cardiology Dispensary after ACS was carried out. Optimal medication therapy was prescribed as part of the preferential provision of medicines under the 1H Program, including high-dose atorvastatin therapy (80 mg/day). Low-density lipoprotein cholesterol (LDL-C) was assessed at baseline and 1 and 12 months after therapy. Hyporesponse to statins was defined as the percentage reduction in LDL-C 14; left atrial volume index >34 ml/m2) function.Results. There were 107 patients with hyporesponse (26,8%). Depending on the initial response to therapy, patients were divided into two groups: group 1 (hyporesponse, n=107), group 2 (more pronounced response, n=293). After 1 month, patients in the hyporesponse group had a higher level of LDL-C — 2,4 [2,2; 2,9] mmol/l (Me [25; 75%]) vs 2,0 [1,7; 2,5] mmol/l (p>0,05) in the second group. There was no difference in the prevalence of hospitalizations for recurrent ACS in the compared groups, as well as in the prevalence of new HF cases between groups.Conclusion. The prevalence of hyporesponse to statin therapy was 26,8%, which required correction of lipid-lowering therapy in order to prevent recurrent cardiovascular events. Given the pleiotropic effects of statins that can participate in HF pathogenesis, as well as the inconsistency of current research results, further prospective long-term studies are required.
Role of humoral markers in the pathogenesis of heart failure with preserved ejection fraction in patients with non-obstructive coronary artery disease
Authors: Grakova E. V. , Kop’eva K. V. , Gusakova A. M. , Smorgon A. V. , Maltseva A. N. , Mochula A. V. , Zavadovsky K. V. 
Published: November 2022

Aim. To study the role of molecular biomarkers potentially influencing the formation and progression of heart failure (HF) with preserved ejection fraction (HFpEF) in non-obstructive coronary artery disease (CAD).Material and methods. We examined 48 patients with newly diagnosed HFpEF against the background of non-obstructive CAD. Group 1 (n=31) included patients with class I-II HF and group 2 (n=17) included patients with class III HF; the control group consisted of patients without heart failure (n=17). The content of NT-proBNP and sST2, diastolic dysfunction and coronary flow reserve parameters were assessed.Results. The content of NT-proBNP in patients of group 1 was 45% higher than in group 2 (p<0,001). The mean levels of sST2 did not exceed the reference values and significantly exceeded the control group (p<0,001). Coronary flow reserve (CFR) decreased (p<0,001) depending on the severity of HF. Negative associations of sST2 levels with LVEF, septal e’ and CFR were revealed, as well as NT-proBNP with CFR.Conclusion. HFpEF in non-obstructive CAD is triggered due to progressive impairment of endothelial function, which affects the decrease in coronary and myocardial flow reserves, diastolic function, hyperproduction of humoral factors that initiate perivascular fibrosis and apoptosis of cardiomyocytes.