bluuebunny/crossref_metadata_2025_split huggingface dataset:
White-matter abnormalities in presymptomaticGRNandC9orf72mutation carriers
Authors: Lee Hyunwoo , Mackenzie Ian R A , Beg Mirza Faisal , Popuri Karteek , Rademakers Rosa , Wittenberg Dana , Hsiung Ging-Yuek Robin 
Published: December 2022

AbstractA large proportion of familial frontotemporal dementia is caused by TAR DNA-binding protein 43 (transactive response DNA-binding protein 43 kDa) proteinopathies. Accordingly, carriers of autosomal dominant mutations in the genes associated with TAR DNA-binding protein 43 aggregation, such as Chromosome 9 open reading frame 72 (C9orf72) or progranulin (GRN), are at risk of later developing frontotemporal dementia. Brain imaging abnormalities that develop before dementia onset in mutation carriers may serve as proxies for the presymptomatic stages of familial frontotemporal dementia due to a genetic cause. Our study objective was to investigate brain MRI-based white-matter changes in predementia participants carrying mutations in C9orf72 or GRN genes. We analysed mutation carriers and their family member controls (noncarriers) from the University of British Columbia familial frontotemporal dementia study. First, a total of 42 participants (8 GRN carriers; 11 C9orf72 carriers; 23 noncarriers) had longitudinal T1-weighted MRI over ∼2 years. White-matter signal hypointensities were segmented and volumes were calculated for each participant. General linear models were applied to compare the baseline burden and the annualized rate of accumulation of signal abnormalities among mutation carriers and noncarriers. Second, a total of 60 participants (9 GRN carriers; 17 C9orf72 carriers; 34 noncarriers) had cross-sectional diffusion tensor MRI available. For each participant, we calculated the average fractional anisotropy and mean, radial and axial diffusivity parameter values within the normal-appearing white-matter tissues. General linear models were applied to compare whether mutation carriers and noncarriers had different trends in diffusion tensor imaging parameter values as they neared the expected age of onset. Baseline volumes of white-matter signal abnormalities were not significantly different among mutation carriers and noncarriers. Longitudinally, GRN carriers had significantly higher annualized rates of accumulation (estimated mean: 15.87%/year) compared with C9orf72 carriers (3.69%/year) or noncarriers (2.64%/year). A significant relationship between diffusion tensor imaging parameter values and increasing expected age of onset was found in the periventricular normal-appearing white-matter region. Specifically, GRN carriers had a tendency of a faster increase of mean and radial diffusivity values and C9orf72 carriers had a tendency of a faster decline of fractional anisotropy values as they reached closer to the expected age of dementia onset. These findings suggest that white-matter changes may represent early markers of familial frontotemporal dementia due to genetic causes. However, GRN and C9orf72 mutation carriers may have different mechanisms leading to tissue abnormalities.
Mixed logit models and network formation
Authors: Gupta Harsh , Porter Mason A 
Published: December 2022

AbstractThe study of network formation is pervasive in economics, sociology, and many other fields. In this article, we model network formation as a ‘choice’ that is made by nodes of a network to connect to other nodes. We study these ‘choices’ using discrete-choice models, in which agents choose between two or more discrete alternatives. We employ the ‘repeated-choice’ (RC) model to study network formation. We argue that the RC model overcomes important limitations of the multinomial logit (MNL) model, which gives one framework for studying network formation, and that it is well-suited to study network formation. We also illustrate how to use the RC model to accurately study network formation using both synthetic and real-world networks. Using edge-independent synthetic networks, we also compare the performance of the MNL model and the RC model. We find that the RC model estimates the data-generation process of our synthetic networks more accurately than the MNL model. Using a patent citation network, which forms sequentially, we present a case study of a qualitatively interesting scenario—the fact that new patents are more likely to cite older, more cited, and similar patents—for which employing the RC model yields interesting insights.
Effectiveness and Safety of Tofacitinib in the Management of Ulcerative Colitis: A Brazilian Observational Multicentric Study
Authors: Perin Ramir Luan , Magro Daniela Oliveira , Andrade Adriana Ribas , Argollo Marjorie , Carvalho Nayara Salgado , Damião Adérson Omar Moura Cintra , Dotti Adriana Zanoni , Ferreira Sandro da Costa , Flores Cristina , Ludvig Juliano Coelho , Nones Rodrigo Bremer , Queiroz Natalia Sousa Freitas , Parra Rogério Serafim , Steinwurz Flavio , Teixeira Fabio Vieira , Kotze Paulo Gustavo 
Published: December 2022

Abstract

Background
Ulcerative colitis (UC) is a chronic inflammatory bowel disease which affects the colorectal mucosa with a relapsing–remitting pattern. The therapeutic options currently available for the medical management of UC include many options. Tofacitinib is an oral small molecule, Janus kinase (JAK) inhibitor, more selective for JAK1 and JAK3, which reduces the inflammatory process involved in the pathogenesis of UC.

Methods
Retrospective observational multicentric study of patients with UC who used tofacitinib in any phase of their treatment. Clinical remission and response (according to Mayo score), mucosal healing, primary and secondary loss of response, discontinuation of the drug with possible causes, and the need for dose optimization or switching to biologicals, need for surgery and adverse events were evaluated.

Results
From a total of 56 included patients, clinical remission was observed in 43.6% at week 12, 54.5% at week 26, 57.9% at week 52, and 40% at the last follow-up visit. Clinical response was observed in 71.4%, 81.8%, 89.5%, and 61.8% at the same time periods, respectively. Mucosal healing rates were 50% and 17.8% needed colectomy.

Conclusions
Tofacitinib was effective in induction and maintenance of clinical response and remission rates, compatible to other international real-word studies and meta-analyses.
Magnetic sphincter augmentation and high-resolution manometry: impact of biomechanical properties on esophageal motility and clinical significance for selection and outcomes
Authors: Eriksson Sven E , Jobe Blair A , Ayazi Shahin 
Published: December 2022

Summary
Magnetic sphincter augmentation (MSA)was introduced as an alternative to laparoscopic Nissen fundoplication (LNF). This reproducible, outpatient procedure addresses the etiology of gastroesophageal reflux disease by implanting a ring of magnetic beads across the esophagogastric junction (EGJ). MSA is designed to resist effacement of the lower esophageal sphincter (LES) and, similar to LNF, results in restoration of anti-reflux barrier competency by increasing overall length, intraabdominal length and resting pressure of the sphincter. However, the novel use of magnets to augment the physiology of the LES poses unique challenges to the physiology of the EGJ and esophagus. These impacts are best revealed through manometry. The degree of restrictive forces at the EGJ, as measured by intrabolus pressure and integrated relaxation pressure, is higher after MSA compared with LNF. In addition, contrary to the LNF, which retains neurohormonal relaxation capability during deglutition, the magnetic forces remain constant until forcibly opened. Therefore, the burden of overcoming EJG resistance is placed solely on the esophageal body contractile force, as measured by distal contractile integral and distal esophageal amplitude. The main utility of preoperative manometry is in determining whether a patient’s esophagus has sufficient contractility or peristaltic reserve to adapt to the challenge of an MSA. Manometric thresholds predictive of MSA outcomes deviate from those used to define named Chicago Classification motility disorders. Therefore, individual preoperative manometric characteristics should be analyzed to aid in risk stratification and patient selection prior to MSA.
Redo aortic arch replacement through a second transcostal approach for closure of type 1A endoleak after endovascular treatment of type B aortic dissection in Marfan syndrome
Authors: Meinert Étienne Fasolt Richard Corvin , Arif Rawa , Karck Matthias 
Published: December 2022

Abstract
A 41-year-old woman with Marfan syndrome suffering from chronic expanding type A dissection of the distal aortic arch and pectus excavatum underwent aortic arch replacement through a left parasternal approach. We demonstrate that this approach is also feasible in complex redo surgery on the aortic arch in selected patients.
Getting ahead of the game: in-hospital initiation of HFrEF therapies
Authors: Biegus Jan , Moayedi Yasbanoo , Saldarriaga Clara , Ponikowski Piotr 
Published: December 2022

Abstract
Hospitalizations for heart failure (HF) have become a global problem worldwide. Each episode of HF decompensation may lead to deleterious short- and long- term consequences, but on the other hand is an unique opportunity to adjust the heart failure pharmacotherapy. Thus, in-hospital and an early post-discharge period comprise an optimal timing for initiation and optimization of the comprehensive management of HF. This timeframe affords clinicians an opportunity to up titrate and adjust guideline-directed medical therapies (GDMT) to potentially mitigate poor outcomes associated post-discharge and longer-term. This review will cover this timely concept, present the data of utilization of GDMT in HF populations, discuss recent evidence for in-hospital initiation and up-titration of GDMT with a need for post-discharge follow-up and implementation this into clinical practice in patients with heart failure and reduced ejection fraction.
Stand Inventories as an Early Detection System for Forest Health Threats
Authors: Klockow Paul A , Edgar Christopher B , Windmuller-Campione Marcella A , Baker Fred A 
Published: December 2022

Abstract
Pest-specific inventories require substantial resources and are often infeasible, creating a need for alternative means of early pest detection. We examined the potential for stand inventories to detect forest health threats by using a unique dataset of mapped eastern spruce dwarf mistletoe (Arceuthobium pusillum Peck.) infestations in black spruce (Picea mariana Mill. B.S.P) stands of northern Minnesota, USA. We simulated stand inventories across a range of sampling intensities; that is, current standard (S) methods in Minnesota, adding one plot (S + 1), doubling the intensity (2S), and halving the intensity (S/2), using fixed-radius plots and transect buffers for detection. We categorized stands into low, moderate, and high infestation severity. We simulated detection at multiple viewing distances along S inventory transects in low severity infestation stands. Detection probability increased as sampling intensity increased. Plot-based detection averaged &gt; 50% for moderate and high severity infestations except S/2 in moderate severity infestations. Notably, transect-based detection averaged ≥ 85% at viewing distances of 25 to 100 m. Results suggest stand inventories could provide opportunities to detect forest health threats with unique signatures when transect observations are included. Thus, forest health specialists may consider including pest-specific training for foresters in current inventory methods, requiring modest investment of time and effort.
Quantitative Assessment of Climate Change Impacts on Forest Ecosystems
Authors: Liu Dan , Yan Hao , Yu Cheng Long , Yin Shi Ping , Wang Cheng Wei , Gong Li Juan 
Published: December 2022

AbstractCharacterizing and predicting the response of terrestrial ecosystems to global change is part of the fundamental challenges of contemporary ecology and ecological conservation. The assessment of climate change impact on forest ecosystems has rarely used a multi-index fusion method for quantitative evaluation. We used forest distribution, net primary productivity, and vegetation coverage to establish an assessment model of the impact of climate change on forest ecosystems. We analyzed the change characteristics of these indicators in the Heilongjiang Province of China. Our results indicate the following: (1) from 2001 to 2019, the forest area in Heilongjiang Province ranged from 234,000 to 246,000 km2. The forest net primary productivity (NPP) ranged from 4.40 to 5.55 MgC·ha-1·yr-1, and the vegetation coverage ranged from 42.42% to 67.64%. The forest NPP and the vegetation coverage showed a significant upward trend. (2) The values of forest ecological roles were significantly positively correlated with the climatic potential. (3) The contribution rate of climate change to forest ecosystem change was negatively correlated with forest coverage, which varied from 4.79% to 18.07% in different regions (cities) of the province.Study Implications: Assessing the influence of climate on forest ecosystems comprehensively and accurately before the government prepares ecological measures is necessary. However, the responses of vegetation coverage and net primary productivity to climate change may not be consistent, so climate studies that consider forest ecosystem change trends by a single indicator may have confounding results. We established a model for evaluating the impact of climate change on forest ecosystems to solve this problem. This knowledge may provide a reference for the response, adaptation, and vulnerability assessment of forest ecosystems to climate change.
Chromosome-scale genome assembly of Eustoma grandiflorum, the first complete genome sequence in the genus Eustoma
Authors: Shirasawa Kenta , Arimoto Ryohei , Hirakawa Hideki , Ishimori Motoyuki , Ghelfi Andrea , Miyasaka Masami , Endo Makoto , Kawabata Saneyuki , Isobe Sachiko N 
Published: December 2022

Abstract
Eustoma grandiflorum (Raf.) Shinn. is an annual herbaceous plant native to the southern United States, Mexico, and the Greater Antilles. It has a large flower with a variety of colors and is an important flower crop. In this study, we established a chromosome-scale de novo assembly of E. grandiflorum genome sequences by integrating four genomic and genetic approaches: (1) Pacific Biosciences (PacBio) Sequel deep sequencing, (2) error correction of the assembly by Illumina short reads, (3) scaffolding by chromatin conformation capture sequencing (Hi-C), and (4) genetic linkage maps derived from an F2 mapping population. Thirty-six pseudomolecules and 64 unplaced scaffolds were created, with a total length of 1,324.8 Mb. A total of 36,619 genes were predicted on the genome as high-confidence genes. A comparison of genome structure between E. grandiflorum and C. canephora or O. pumila suggested whole-genome duplication after the divergence between the families Gentianaceae and Rubiaceae. Phylogenetic analysis with single-copy genes suggested that the divergence time between Gentianaceae and Rubiaceae was 74.94 MYA. Genetic diversity analysis was performed for nine commercial E. grandiflorum varieties bred in Japan, from which 254,205 variants were identified. This first report on the construction of a reference genome sequence in the genus Eustoma is expected to contribute to genetic and genomic studies in this genus and in the family Gentianaceae.
Knowledge, attitude and practice of community pharmacists towards household pharmaceutical waste disposal
Authors: Low Bee Yean , Ting Kang Nee , Lee Mei Kee 
Published: December 2022

AbstractObjectiveTo assess the knowledge, attitude and practice of community pharmacists (CP) towards household pharmaceutical waste disposal.MethodsAll pharmacists attending the Malaysian Community Pharmacy Guild event held in-person were invited to self-administer a web-based survey.Key findingsThe response rate was 61% (168/276). Overall, community pharmacists have mixed knowledge (mean ± SD: 5.89 ± 1.38) and positive attitude (mean ± SD: 9.58 ± 0.81) towards household pharmaceutical waste disposal. However, few community pharmacists (18/168, 10.7%) have promotional materials encouraging safe medication disposal in their pharmacies.ConclusionsCommunity pharmacists do not proactively promote safe household pharmaceutical waste disposal to mitigate pharmaceutical pollutants entering the environment although they have satisfactory knowledge and attitude.
Repurposing crizotinib to target RIPK1-dependent cell death
Authors: Yu Yajie , Li Min , Fu Shufang , He Xiaoyan , Hu Xinqian , Zhu Guofeng , Wang Jia , You Xiaoling , Mou Yan , Ye Zhi , Wei Jun , Zha Yunhong 
Published: December 2022

Abstract
Receptor-interacting protein kinase 1 (RIPK1) has emerged as a key regulator of cell death and inflammation, which are implicated in the pathogenesis of many inflammatory and degenerative diseases. RIPK1 is therefore a putative therapeutic target in many of these diseases. However, no pharmacological inhibitor of RIPK1-mediated cell death is currently in clinical use. Recognizing that a repurposed drug has an expedited clinical development pipeline, here we performed a high-throughput drug screen of Food and Drug Administration (FDA)-approved compounds and identified a novel use for crizotinib as an inhibitor of RIPK1-dependent cell death. Furthermore, crizotinib rescued TNF-α-induced death in mice with systemic inflammatory response syndrome. RIPK1 kinase activity was directly inhibited by crizotinib. These findings identify a new use for an established compound and are expected to accelerate drug development for RIPK1-spectrum disorders.
Standard Venipuncture vs a Capillary Blood Collection Device for the Prospective Determination of Abnormal Liver Chemistry
Authors: Wickremsinhe Enaksha , Fantana Antoniu , Berthier Erwin , Quist Brook A , Lopez de Castilla Diego , Fix Charles , Chan Kahlil , Shi Jing , Walker Michael G , Kherani Jennifer F , Knoderer Holly , Regev Arie , Harding James J 
Published: December 2022

Abstract

Background
Abnormal liver function is a common manifestation of human disease and may also occur in approved and investigational medications as drug-induced liver injury (DILI). Capillary blood collection devices may allow for more frequent and convenient measurement outside of the clinic. Validation of such approaches is lacking.

Methods
This prospective, biospecimens collection study evaluated the Tasso+ in patients with abnormal liver tests (NCT05259618). The primary objective was to define the concordance of alanine aminotransferase (ALT) obtained via Tasso+ compared to standard venipuncture. Secondary objectives included measurement of 14 other analytes and patient surveys. At the time of venipuncture, 2 Tasso+ samples were collected: one was centrifuged and shipped, and the other was refrigerated and shipped as whole blood.

Results
Thirty-six patients with elevated ALT values were enrolled. In total, 100 venipuncture, 50 Tasso+ centrifuged, and 48 Tasso+ whole blood samples were obtained. Tasso+ centrifuged samples demonstrated concordance correlation coefficients (CCC) of &gt;0.99 for ALT, alkaline phosphatase (ALP), aspartate aminotransferase (AST), and total bilirubin and CCC &gt;0.95 for albumin, chloride, enzymatic creatinine, serum glucose, magnesium, and phosphorus. Tasso+ whole blood showed CCC of &gt;0.99 for AST, bilirubin total, and enzymatic creatinine and CCC &gt;0.95 for ALT, ALP, albumin, magnesium, and phosphorus. Hemolysis was comparable across the 3 sample types, but its impact was reflected in the Tasso+ potassium data. Patient feedback indicated a very favorable patient experience.

Conclusions
The capillary blood collection device, Tasso+, showed substantial to almost perfect concordance to standard venipuncture for measurement of abnormal liver function. Studies are ongoing to validate longitudinal sampling outside of the clinic.
Clinicaltrials.gov Registration Number: NCT05259618
A control technique for hybrid floating offshore wind turbines using oscillating water columns for generated power fluctuation reduction
Authors: Aboutalebi Payam , M’zoughi Fares , Garrido Izaskun , Garrido Aitor J 
Published: December 2022

Abstract
The inherent oscillating dynamics of floating offshore wind turbines (FOWTs) might result in undesirable oscillatory behavior in both the system states and the generated power outputs, leading to unwanted effects on critical, extreme, and fatigue loads, and finally to a premature failure of the facility. Therefore, this kind of system should be capable of lessening such undesired effects. In this article, four oscillating water columns (OWC) have been installed within a FOWT barge-type platform. A novel switching control technique has been developed in order to reduce oscillations of the system created by both wind and wave, as well as the fluctuations in the generated power, by adequately regulating the airflow control valves. While the impact of the coupled wind-wave loads has been considered, a set of representative case studies have been taken into account for a range of regular waves and wind speeds. The study relies on the use of response amplitude operators (RAO) that have been pre-processed and evaluated in order to apply the switching control technique. In this sense, the starting time of the switching for below-rated, rated, and above-rated wind speeds have been calculated using the platform’s corresponding pitch RAO. Additionally, the blades’ pitch and generator torque have also been regulated by means of a constant torque variable speed controller to capture maximum energy for below-rated wind speed conditions and to match the rated generator power for rated and above-rated wind speed conditions, respectively. In order to peruse the feasibility and performance of the proposed strategy, a comparison has been carried out between the uncontrolled traditional barge-type platform and the controlled OWCs-based barge FOWT. The results demonstrate that the proposed control approach can effectively and successfully decrease both the oscillations in the system’s modes and the fluctuations in the generated power.
The Upscaling Effect: How the Decision Context Influences Tradeoffs between Desirability and Feasibility
Authors: Evangelidis Ioannis , Levav Jonathan , Simonson Itamar 
Published: December 2022

Abstract
Purchase decisions typically involve tradeoffs between attributes associated with desirability (e.g., quality) and feasibility (e.g., price). In this article, we examine how the decision context impacts consumers’ preference between a high-desirability (HD) option and a high-feasibility (HF) alternative. Nineteen studies demonstrate a novel context effect, the “upscaling effect,” whereby introducing a symmetrically dominated decoy option to a set (i.e., an option that is inferior compared to all alternatives in the set) leads to an increase in the choice share of the HD option. To account for the upscaling effect, we advance a two-stage model of consumer decision-making for decisions that involve tradeoffs between desirability and feasibility. According to our model, when the decision context provides a reason for choosing either option, such as when a decoy option is added to the set, consumers prioritize reasons that support choice of HD options over HF alternatives. Our model can explain the upscaling effect, as well as other findings reported in the literature, such as asymmetric attraction effects (Heath and Chatterjee 1995) and asymmetric sales promotion effects (Blattberg and Wisniewski 1989). Furthermore, the upscaling effect holds important managerial implications because it provides an effective way to increase sales of high-end products.