bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renin: Measurements, Correlates, and Associations With Long-Term Adverse Kidney Outcomes
Authors: Blum Matthew F , Chen Jingsha , Surapaneni Aditya , Turner Stephen T , Ballantyne Christie M , Welling Paul A , Köttgen Anna , Coresh Josef , Crews Deidra C , Grams Morgan E 
Published: October 2022

Abstract

Background
The association of renin with adverse kidney outcomes is largely unknown, and renin measurement strategies vary. We aimed to measure the clinical correlates of different renin measurements and the association between renin and incident chronic kidney disease (CKD), end-stage kidney disease (ESKD), and mortality.

Methods
We performed a prospective cohort analysis of 9,420 participants in the Atherosclerosis Risk in Communities study followed from 1996 to 1998 through 2019. We estimated longitudinal associations of renin measured using SomaScan modified nucleotide aptamer assay with incident CKD, ESKD, and death using Cox proportional hazards models. Using samples from a subsequent study visit, we compared SomaScan renin with plasma renin activity (PRA) and renin level from Olink, and estimated associations with covariates using univariate and multivariable regression.

Results
Higher SomaScan renin levels were associated with a higher risk of incident CKD (hazard ratio per two-fold higher [HR], 1.14; 95% confidence interval [CI], 1.09 to 1.20), ESKD (HR, 1.20; 95% CI, 1.03 to 1.41), and mortality (HR, 1.08; 95% CI, 1.04 to 1.13) in analyses adjusted for demographic, clinical, and socioeconomic covariates. SomaScan renin was moderately correlated with PRA (r = 0.61) and highly correlated with Olink renin (r = 0.94). SomaScan renin and PRA had similar clinical correlates except for divergent associations with age and beta-blocker use, both of which correlated positively with SomaScan renin but negatively with PRA.

Conclusions
SomaScan aptamer-based renin level was associated with a higher risk of CKD, ESKD, and mortality. It was moderately correlated with PRA, sharing generally similar clinical covariate associations.
Second-hand Smoke Exposure Among Home Care Workers (HCWs) in Scotland
Authors: Dobson Ruaraidh , O’Donnell Rachel , McGibbon Mary , Semple Sean 
Published: October 2022

Abstract

Objectives
Second-hand tobacco smoke (SHS) is a serious cause of ill-health, and concern around SHS exposure at work has driven legislation in public places. In Scotland, most workers are now protected from SHS at work. However, home care workers (HCWs) may still be exposed, as they enter private homes where smoking is unregulated. In this study, we aimed to understand the extent, duration and intensity of that exposure among HCWs in Lanarkshire, Scotland.

Methods
We surveyed HCWs in four organisations involved in providing care at home: a public healthcare agency (NHS Lanarkshire), two local government entities and a private healthcare company. We also conducted personal exposure monitoring (PEM) of exposure to airborne nicotine and SHS-related fine particulate matter (PM2.5) with 32 HCWs.

Results
The vast majority of HCWs surveyed reported being exposed to SHS at work (395/537, 74%), and 50% of those who reported exposure in the home indicated daily exposure. We conducted PEM over 82 home visits, with 21% (17) demonstrating PM2.5 concentrations in excess of the WHO’s 2010 air quality guideline limit for 24 h exposure. Duration of exposure to SHS tended to be short and as a result all nicotine samples were below the limit of quantification.

Conclusions
Most HCWs are exposed to minimal levels of SHS at work. However, a minority may be exposed to concentrations which affect health. Policies to mitigate this exposure should be considered, such as the use of respiratory protective equipment, improved ventilation during visits, and interventions to reduce smoking in homes.
Party crashers: issues in identifying parties and others bound by arbitration agreements
Authors: Allison Simon , Dharmananda Kanaga 
Published: October 2022

Abstract
The determination of the law governing arbitration agreements has been the subject of recent close attention. The relationship of third parties to arbitration agreements is sensitive to an increasingly unwieldly array of factors, including the subject matter of a dispute, the nature of the purported basis for the transfer of an arbitration agreement, and the wording of the original instrument containing the arbitration clause. A rising question is whether third parties are to be considered parties or non-parties otherwise bound by arbitration agreements. In addition, there is an issue of timing: when are the arbitration agreements or relevant awards to be impugned, and does the third-party issue pertain to the validity or just the scope of an arbitration agreement. This article seeks to address these issues.
Predicting the structure of unexplored novel fentanyl analogues by deep learning model
Authors: Zhang Yuan , Jiang Qiaoyan , Li Ling , Li Zutan , Xu Zhihui , Chen Yuanyuan , Sun Yang , Liu Cheng , Mao Zhengsheng , Chen Feng , Li Hualan , Cao Yue , Pian Cong 
Published: October 2022

Abstract
Fentanyl and its analogues are psychoactive substances and the concern of fentanyl abuse has been existed in decades. Because the structure of fentanyl is easy to be modified, criminals may synthesize new fentanyl analogues to avoid supervision. The drug supervision is based on the structure matching to the database and too few kinds of fentanyl analogues are included in the database, so it is necessary to find out more potential fentanyl analogues and expand the sample space of fentanyl analogues. In this study, we introduced two deep generative models (SeqGAN and MolGPT) to generate potential fentanyl analogues, and a total of 11 041 valid molecules were obtained. The results showed that not only can we generate molecules with similar property distribution of original data, but the generated molecules also contain potential fentanyl analogues that are not pretty similar to any of original data. Ten molecules based on the rules of fentanyl analogues were selected for NMR, MS and IR validation. The results indicated that these molecules are all unreported fentanyl analogues. Furthermore, this study is the first to apply the deep learning to the generation of fentanyl analogues, greatly expands the exploring space of fentanyl analogues and provides help for the supervision of fentanyl.
statgenMPP: an R package implementing an IBD-based mixed model approach for QTL mapping in a wide range of multi-parent populations
Authors: Li Wenhao , Boer Martin P , van Rossum Bart-Jan , Zheng Chaozhi , Joosen Ronny V L , van Eeuwijk Fred A 
Published: October 2022

AbstractMotivationMulti-parent populations (MPPs) are popular for QTL mapping because they combine wide genetic diversity in parents with easy control of population structure, but a limited number of software tools for QTL mapping are specifically developed for general MPP designs.ResultsWe developed an R package called statgenMPP, adopting a unified identity-by-descent (IBD)-based mixed model approach for QTL analysis in MPPs. The package offers easy-to-use functionalities of IBD calculations, mixed model solutions and visualizations for QTL mapping in a wide range of MPP designs, including diallele, nested-association mapping populations, multi-parent advanced genetic inter-cross populations and other complicated MPPs with known crossing schemes.Availability and implementationThe R package statgenMPP is open-source and freely available on CRAN at https://CRAN.R-project.org/package=statgenMPPSupplementary informationSupplementary data are available at Bioinformatics online.
Rapid transcriptomic and physiological changes in the freshwater pennate diatomMayamaea pseudoterrestrisin response to copper exposure
Authors: Suzuki Shigekatsu , Ota Shuhei , Yamagishi Takahiro , Tuji Akihiro , Yamaguchi Haruyo , Kawachi Masanobu 
Published: October 2022

AbstractDiatoms function as major primary producers, accumulating large amounts of biomass in most aquatic environments. Given their rapid responses to changes in environmental conditions, diatoms are used for the biological monitoring of water quality and for performing ecotoxicological tests in aquatic ecosystems. However, the molecular basis for their toxicity to chemical compounds remains largely unknown. Here, we sequenced the genome of a freshwater diatom, Mayamaea pseudoterrestris NIES-4280, which has been proposed as an alternative strain of Navicula pelliculosa UTEX 664 for performing the Organisation for Economic Co-operation and Development ecotoxicological test. This study shows that M. pseudoterrestris has a small genome and carries the lowest number of genes among freshwater diatoms. The gene content of M. pseudoterrestris is similar to that of the model marine diatom, Phaeodactylum tricornutum. Genes related to cell motility, polysaccharide metabolism, oxidative stress alleviation, intracellular calcium signalling, and reactive compound detoxification showed rapid changes in their expression patterns in response to copper exposure. Active gliding motility was observed in response to copper addition, and copper exposure decreased intracellular calcium concentration. These findings enhance our understanding of the environmental adaptation of diatoms, and elucidate the molecular basis of toxicity of chemical compounds in algae.
Comparison of treatment outcomes between endoscopic submucosal dissection with the needle-type knife and insulated-tip knife for superficial esophageal neoplasms
Authors: Esaki Mitsuru , Yoshida Masao , Takizawa Kohei , Notsu Akifumi , Nonaka Satoru , Shichijo Satoki , Suzuki Sho , Sato Chiko , Komori Hiroyuki , Minagawa Takeyoshi , Oda Ichiro , Uedo Noriya , Hirasawa Kingo , Matsumoto Kenshi , Sumiyoshi Tetsuya , Abe Seiichiro , Gotoda Takuji , Ono Hiroyuki 
Published: October 2022

SummaryOur study aimed to compare the treatment outcomes between endoscopic submucosal dissection (ESD) with an insulated-tip knife (ESD-IT) and a needle-type knife (ESD-N) for large superficial esophageal neoplasms, as no study of this kind has been previously reported. We used the dataset of a multicenter, randomized controlled trial that compared conventional ESD (C-ESD) and traction-assisted ESD (TA-ESD) for superficial esophageal neoplasms. We compared the procedural outcomes between ESD-IT and ESD-N in a post hoc analysis and conducted sub-analyses based on traction assistance and electrical knife type. We included 223 (EST-IT, n = 169; ESD-N, n = 54) patients with no significant differences in baseline characteristics. The operator handover rate due to ESD difficulties was significantly higher in ESD-N (ESD-IT = 0.6% vs. ESD-N = 13.0%, P = 0.001), while the injection volume was significantly higher in ESD-IT than in ESD-N (40.0 vs. 20.5 mL, P &lt; 0.001). Other outcomes were comparable between both groups (procedural time: 51.0 vs. 49.5 minute, P = 0.89; complete resection: 90.5% vs. 90.7%, P &gt; 0.99; and complication rate: 1.8% vs. 3.7%, P = 0.60 for ESD-IT and ESD-N, respectively). In the sub-analyses, the handover rate was significantly lower with TA-ESD than with C-ESD for ESD-N (3.2% vs. 26.1%, P = 0.034), and a significantly smaller injection volume was used in TA-ESD than in C-ESD for ESD-IT (31.5 vs. 47.0 mL, P &lt; 0.01). ESD with either endoscopic device achieved favorable treatment outcomes with low complication rates. The handover rate in ESD-N and the injection volume in ESD-IT improved with the traction method.
COVID-19 in a patient implanted with a total artificial heart: a case report
Authors: Lutun Juliette , Fauvel Charles , Gay Arnaud , Bauer Fabrice 
Published: October 2022

Abstract

Background
The coronavirus disease 2019 (COVID-19) was first identified in December 2019 and is currently still a public health issue affecting millions of people worldwide. Heart failure patients are known to be at higher risk of morbidity and mortality in this case. Yet, few data exist concerning COVID-19 among patients with a left ventricular assistance device, and even less among those with a total artificial heart (TAH).

Case summary
A 27-year-old man with Marfan syndrome underwent prophylactic ascending aorta replacement. Shortly after surgery completion, he developed refractory cardiogenic shock with biventricular dysfunction leading to veno-arterial extracorporeal membrane oxygenation (VA-ECMO) implantation. In the context of no appropriate eligible donor during the following 10 days while waiting on the heart transplantation list, the patient was scheduled for a TAH as a bridge to transplantation. Meanwhile, he developed an acute respiratory distress syndrome secondary to SARS-CoV-2. The patient was successfully treated with corticosteroids, prone positioning and mechanical ventilation, and heart transplantation occurred 5 weeks after COVID-19 onset.

Discussion
Here, we report the first case of a patient presenting with COVID-19 infection following TAH implantation in a bridge to transplantation. We highlight that (i) cardiogenic shock patients simultaneously infected by COVID-19 should be treated instantly with all-time available technology to ensure best outcomes, including TAH and prone positioning, (ii) heart transplantation safety 5 weeks after COVID-19 onset.
Regional implementation of atrial fibrillation screening: benefits and pitfalls
Authors: Theunissen Luc J H J , Abdalrahim Reyan B E M , Dekker Lukas R C , Thijssen Eric J M , de Jong Sylvie F A M S , Polak Peter E , van de Voort Pepijn H , Smits Geert , Scheele Karin , Lucas Annelies , van Veghel Dennis P A , Cremers Henricus-Paul , van de Pol Jeroen A A , Kemps Hareld M C 
Published: October 2022

AbstractAimsDespite general awareness that screening for atrial fibrillation (AF) could reduce health hazards, large-scale implementation is lagging behind technological developments. As the successful implementation of a screening programme remains challenging, this study aims to identify facilitating and inhibiting factors from healthcare providers’ perspectives.Methods and resultsA mixed-methods approach was used to gather data among practice nurses in primary care in the southern region of the Netherlands to evaluate the implementation of an ongoing single-lead electrocardiogram (ECG)-based AF screening programme. Potential facilitating and inhibiting factors were evaluated using online questionnaires (N = 74/75%) and 14 (of 24) semi-structured in-depth interviews (58.3%). All analyses were performed using SPSS 26.0. In total, 16 682 screenings were performed on an eligible population of 64 000, and 100 new AF cases were detected. Facilitating factors included ‘receiving clear instructions’ (mean ± SD; 4.12 ± 1.05), ‘easy use of the ECG-based device’ (4.58 ± 0.68), and ‘patient satisfaction’ (4.22 ± 0.65). Inhibiting factors were ‘time availability’ (3.20 ± 1.10), ‘insufficient feedback to the practice nurse’ (2.15 ± 0.89), ‘absence of coordination’ (54%), and the ‘lack of fitting policy’ (32%).ConclusionLarge-scale regional implementation of an AF screening programme in primary care resulted in a low participation of all eligible patients. Based on the perceived barriers by healthcare providers, future AF screening programmes should create preconditions to fit the intervention into daily routines, appointing an overall project lead and a General Practitioner (GP) as a coordinator within every GP practice.
Depressive symptoms, cognitive impairment, and all-cause mortality among REGARDS participants with heart failure
Authors: Khodneva Yulia , Ringel Joanna Bryan , Rajan Mangala , Goyal Parag , Jackson Elizabeth A , Sterling Madeline R , Cherrington Andrea , Oparil Suzanne , Durant Raegan , Safford Monika M , Levitan Emily B 
Published: October 2022

Abstract

Aims
To ascertain whether depressive symptoms and cognitive impairment (CI) are associated with mortality among patients with heart failure (HF), adjusting for sociodemographic, comorbidities, and biomarkers.

Methods and results
We utilized Medicare-linked data from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study, a biracial prospective ongoing cohort of 30 239 US community-dwelling adults, recruited in 2003–07. HF diagnosis was ascertained in claims analysis. Depressive symptoms were defined as a score ≥4 on the four-item Center for Epidemiological Studies-Depression scale. Cognitive impairment was defined as a score of ≤4 on the six-item screener that assessed three-item recall and orientation to year, month, and day of the week. Sequentially adjusted Cox proportional hazard models were used to estimate the risk of death. We analyzed 1059 REGARDS participants (mean age 73, 48%—African American) with HF; of those 146 (14%) reported depressive symptoms, 136 (13%) had CI and 31 (3%) had both. Over the median follow-up of 6.8 years (interquartile range, 3.4–10.3), 785 (74%) died. In the socio-demographics-adjusted model, CI was significantly associated with increased mortality, hazard ratio 1.24 (95% confidence interval 1.01–1.52), compared with persons with neither depressive symptoms nor CI, but this association was attenuated after further adjustment. Neither depressive symptoms alone nor their comorbidity with CI was associated with mortality. Risk factors of all-cause mortality included: low income, comorbidities, smoking, physical inactivity, and severity of HF.

Conclusion
Depressive symptoms, CI, or their comorbidity was not associated with mortality in HF in this study. Treatment of HF in elderly needs to be tailored to cognitive status and includes focus on medical comorbidities.
Will wonders never cease? The viola bastarda at the Ferrarese court
Authors: Morton Joëlle 
Published: October 2022

Abstract
Music for the viola bastarda was composed over a period of approximately one hundred years, from the mid 16th to mid 17th century. Initially arising in Italy, it was later transferred to regions north of the Alps in German and Polish regions and across the English Channel. There is interesting variety to the music, with details that prove challenging to modern players and that do not easily align with the previously accepted definition. A particularly large and influential group of composers, performers and patrons coalesced in the second half of the 16th century, centred on the Este court in the Duchy of Ferrara. In exclusive and elite settings, it was sometimes women of high rank who performed this virtuosic music that was composed specially for them, in some cases using particularly large instruments. The nature of this repertory conveyed a true sense of maraviglia and was considered extremely ‘affective’.
eHealth technology use and eHealth literacy after percutaneous coronary intervention
Authors: Ramstad K J , Brørs G , Pettersen T R , Deaton C , Palm P , Rotevatn S , Wentzel-Larsen T , Norekvål T M 
Published: October 2022

Abstract

Aims
Electronic health (eHealth) sources have great potential to improve patients’ access to health information for self-management of secondary prevention after percutaneous coronary intervention (PCI). It remains unclear, however, whether patients are health-related digitally active and whether they have sufficient eHealth literacy. This study aimed to determine the extent to which patients after PCI are health-related digitally active at baseline, 2 and 6 months after PCI, and to determine the association between patients’ eHealth literacy and their health-related digital activity.

Methods and results
This multicentre cohort study included patients at three large referral PCI centres in Norway (n = 1970). Data were collected from medical records, national registries, and patients’ self-reports. The eHealth Literacy Scale (eHEALS) assessed patients’ eHealth literacy. At baseline, 67% had used the internet to find health information. The mean eHEALS score was 25.71 (standard deviation 6.22), illustrating a lower level of eHealth literacy. There were substantial associations between eHealth literacy and use of the internet to find health information [coefficient 10.90, 95% confidence interval (CI) 8.05–14.57]. At the 2-month follow-up, there were substantial associations between baseline eHealth literacy and use of the internet to find information about health, prevention, illness, or treatment [odds ratio (OR) 1.19, 95% CI 1.14–1.24] and use of health applications (OR 1.15, 95% CI 1.08–1.22).

Conclusion
This study provides evidence that patients’ level of eHealth literacy after PCI is associated to how patients use, and can make use of, eHealth technology for health information.

Registration
ClinicalTrials.gov (NCT03810612).
Job Characteristics Associated With Intent to Quit Among Nursing Home Employees and Managers
Authors: Kennedy Katherine A , Mohr David C 
Published: October 2022

Abstract

Background and Objectives
High turnover and recruitment challenges of nursing home employees and managers are an ongoing concern. This study’s objective was to examine intent to quit among all staff and assess the roles of job characteristics and job satisfaction. Employees and managers within one nursing home chain working in direct patient care or nursing were compared.

Research Design and Methods
Data came from the Work, Family, Health Network 18-month follow-up survey in 2012 (total = 1,000, managers = 101, employees = 899). A cumulative logit model controlling for demographics was estimated for intent to quit. Herzberg’s Two-Factor Theory of Work Motivation guided the study.

Results
Employees scored significantly lower on family-supportive supervisor behaviors (FSSBs), schedule control, and decision authority than managers. Employees and managers did not differ on job satisfaction, intent to quit, or job demands. Satisfied workers had an 83% decrease in the odds of reporting an intent to quit compared to workers who were neutral or disagreed (odds ratio [OR] = 0.17, p &lt; .0001). Decision authority (OR = 3.49) and schedule control (OR = 5.18) were independently related to greater odds of reporting an intent to quit. In contrast, FSSBs (OR = 0.69), safety compliance (OR = 0.71), and the combination of high decision authority with high schedule control (OR = 0.72) were related to lower odds of reporting an intent to quit.

Discussion and Implications
Among nursing home staff, lower intent to quit may be achieved through improving job satisfaction, the quality of supervision, safety culture, and job enrichment through more schedule control and decision-making power.