bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Ixekizumab in Chinese Patients With Moderate-to-Severe Plaque Psoriasis: 60-Week Results From a Phase 3 Study
Authors: Li Xia , Zheng Jie , Pan Wei-Li , Zheng Min , Lu Yan , Li Fu-Qiu , Ding Yang-Feng , Zhang Jian-Zhong , Li Hong-Ying , Rui Wen-Long 
Published: June 2022

Objective:
Ixekizumab is a high-affinity monoclonal antibody that selectively targets interleukin-17A and is approved for treating moderate-to-severe psoriasis. This phase 3, multicenter, randomized, double-blind, placebo-controlled trial (NCT03364309; registered December 6, 2017) evaluated the safety and efficacy of ixekizumab in Chinese patients with moderate-to-severe psoriasis.

Methods:
438 patients were randomized 2:2:1 to 80 mg ixekizumab every 2 weeks (IXE Q2W, n = 176), 80 mg ixekizumab every 4 weeks (IXE Q4W, n = 174), or placebo (n = 88). Efficacy was assessed by evaluating the static Physician’s Global Assessment score of 0 or 1 (sPGA [0,1]) and Psoriasis Area and Severity Index (PASI) 75/90/100 responses, and nonresponder imputation was used for handling missing data. The safety profile was evaluated by assessing treatment emergent adverse events (AEs) and serious AEs.

Results:
At week 12, the sPGA (0,1) response rates were 3.4%, 79.9%, and 86.4% in the placebo, IXE Q4W, and IXE Q2W groups, respectively. The PASI 75/90/100 response rates were 8.0%/2.3%/0.0%, 87.4%/75.9%/29.3%, and 93.8%/82.4%/33.0% in the placebo, IXE Q4W, and IXE Q2W groups, respectively. Ixekizumab led to rapid PASI 50 responses, as early as week 1, whereas PASI 75 and sPGA (0,1) responses were observed from week 2. sPGA (0,1) and sPGA (0) responses were maintained through week 60 in a higher proportion of patients receiving IXE Q4W vs. placebo. The safety profile was consistent with previous studies of ixekizumab in psoriasis.

Conclusion:
Ixekizumab showed a rapid onset of action and high efficacy that was maintained through 60 weeks and was well tolerated with no unexpected AEs, in Chinese patients with moderate-to-severe plaque psoriasis.
Description of nurse practitioner functioning as most responsible provider in an intravenous therapy clinic
Authors: Klemmer Daris , Shand Wesley , Zibell Cheryl 
Published: June 2022

ABSTRACT

Background:
IV antibiotic patients at the Strathcona Community Hospital were previously seen through the Strathcona emergency department (ED). This led to decreased patient satisfaction and increased wait times for these patients.

Purpose:
The purpose of this study was to describe a nurse practitioner (NP) functioning as the most responsible provider (MRP) in an intravenous therapy (IVT) clinic and to describe the benefits and services the clinic provides within a suburban community hospital setting.

Methods:
Data were collected over a 5-year period from August 2015 to March 2019. Indicators included staff satisfaction, timely change in treatment modality, adherence to antimicrobial stewardship principles, appropriate triaging of IV iron referrals, and continuity of care.

Results:
Results included patients being seen in the IVT clinic rather than reassessment in the ED, which were 23,573; and patient length of stay, with average length of stay being 4.8–4.9 days for skin and soft tissue infections. Patient survey conducted in 2015 showed an 89% satisfaction rate.

Conclusions:
Nurse practitioners functioning as MRP in an IVT clinic improve patient access to services, satisfaction, and provide appropriate medical care.

Implications
The success of this clinical model provides evidence to support an increased presence of NPs as MRPs. A better understanding of the financial breakdown of these clinics may provide additional insight into the full benefit of NP-led clinics on our health care system as a whole.
Lipocalin-2: a novel link between the injured kidney and the bone
Authors: Courbon Guillaume , David Valentin 
Published: June 2022

Purpose of review
Fibroblast growth factor 23 (FGF23) excess is associated with left ventricular hypertrophy (LVH) and early mortality in patients with chronic kidney disease (CKD) and in animal models. Elevated Lipocalin-2 (LCN2), produced by the injured kidneys, contributes to CKD progression and might aggravate cardiovascular outcomes. The current review aims to highlight the role of LCN2 in CKD, particularly its interactions with FGF23.

Recent findings
Inflammation, disordered iron homeostasis and altered metabolic activity are common complications of CKD, and are associated with elevated levels of kidney-produced LCN2 and bone-secreted FGF23. A recent study shows that elevated LCN2 increases FGF23 production, and contributes to cardiac injury in patients and animals with CKD, whereas LCN2 reduction in mice with CKD reduces FGF23, improves cardiovascular outcomes and prolongs lifespan.

Summary
In this manuscript, we discuss the potential pathophysiological functions of LCN2 as a major kidney–bone crosstalk molecule, linking the progressive decline in kidney function to excessive bone FGF23 production. We also review associations of LCN2 with kidney, cardiovascular and bone and mineral alterations. We conclude that the presented data support the design of novel therapeutic approaches to improve outcomes in CKD.
Higher Parenteral Electrolyte Intakes in Preterm Infants During First Week of Life: Effects on Electrolyte Imbalances
Authors: Späth Cornelia , Sjöström Elisabeth Stoltz , Domellöf Magnus 
Published: June 2022

Objectives:
This study aimed to investigate the effects of a higher intake of electrolytes from parenteral nutrition (PN) on plasma electrolyte concentrations in very low birth weight (VLBW, <1500 g) infants.

Methods:
This was a single-center cohort study including all VLBW infants born before (n = 81) and after (n = 53) the implementation of a concentrated PN regimen. Daily nutritional intakes and plasma concentrations of sodium, chloride, potassium, phosphate, and calcium were collected from clinical charts.

Results:
During the first postnatal week, electrolyte intakes were higher in infants who received concentrated PN compared with infants who received original PN. Infants who received concentrated PN had a lower incidence of hypokalemia (<3.5 mmol/L; 30% vs 76%, P < 0.001) and severe hypophosphatemia (<1.0 mmol/L; 2.2% vs 17%, P = 0.02). While the relatively high prevalence of severe hypophosphatemia in infants who received original PN can be explained by a phosphorus intake below the recommendation, the potassium intake during the first 3 postnatal days (mean ± SD: 0.7 ± 0.2 mmol/kg/d) was within the recommendation. The prevalence of early hypernatremia was not affected by the different sodium intake in the 2 groups.

Conclusions:
In VLBW infants, a sodium-containing PN solution (about 2.7 mmol/100 mL) does not cause hypernatremia during the first days of life. Furthermore, providing at least 1 mmol potassium/kg/d during the first 3 postnatal days might be necessary to prevent early hypokalemia.
Pediatric ED Utilization in a Destination City
Authors: Rose Holly S. , Wolf Bethany J. , Pruitt Christopher M. , Kane Ian D. 
Published: June 2022

Objectives
Seasonal variation in emergency department (ED) visits has been shown for a variety of pediatric conditions, but previous studies have not considered how geographic location may also influence when and why these patients present to the ED. Our study examined the demographic and clinical characteristics as well as the seasonal variation among 3 patient populations (locals, in-state nonlocals, and out-of-state visitors) presenting to our pediatric ED (PED), which is located in a coastal, destination city.

Methods
This was a retrospective chart review of PED visits from June 2014 to June 2019 at the Medical University of South Carolina Children's Hospital, a tertiary care facility located in Charleston, SC. Pediatric ED encounters were divided into 3 groups, depending on the patient's home address: local patients residing in the 3 surrounding metro counties, in-state but nonlocal patients, and out-of-state patients. Demographic and clinical information was abstracted for each visit and compared among the 3 patient groups. Seasonal variation among PED visits was determined by recording the week of the year during which each visit occurred.

Results
Local patients accounted for more than 90% of PED visits with increases in visits from October to April. In-state nonlocal patients presented at consistent rates throughout the year, whereas out-of-state ED utilization peaked significantly during the summer months, Spring Break, Thanksgiving, and Christmas. Our local patient population was majority African American; our in-state nonlocal patients roughly matched our state's racial demographics, and our out-of-state population was predominantly White. Compared with in-state nonlocal patients, our local patients were more likely to present with an infection-related complaint and be diagnosed with lower-acuity conditions such as viral infection, otitis media, upper respiratory infection, cough, fever, and gastroenteritis. In-state nonlocal patients had the highest average triage acuity, more frequently had laboratory tests and imaging ordered, and were more than 4.5 times as likely to be admitted to the hospital compared with our local patients. In-state nonlocal patients were also more likely to present with a psychiatric chief complaint compared with our local patients. Out-of-state patients had a similar overall acuity to local patients but were more likely to have imaging ordered and be diagnosed with injuries such as fractures.

Conclusion
At our institution, local patients, in-state nonlocal patients, and out-of-state patients exhibited 3 distinct patterns of PED utilization. Knowledge of these trends can be used to optimize resource allocation and follow-up planning, particularly for our out-of-state patient population.
Examination of SARS-CoV-2 serological test results from multiple commercial and laboratory platforms with an in-house serum panel
Authors: Lester Sandra N. , Stumpf Megan , Freeman Brandi D. , Mills Lisa , Schiffer Jarad , Semenova Vera , Jia Tao , Desai Rita , Browning Peter , Alston Bailey , Ategbole Muyiwa , Bolcen Shanna , Chen Alexander , David Ebenezer , Manitis Panagiotis , Tatum Heather , Qin Yunlong , Zellner Briana , Drobeniuc Jan , Tejada-Strop Alexandra , Chatterjee Payel , Shrivastava-Ranjan Punya , Jenks M. Harley , McMullan Laura K. , Flint Mike , Spiropoulou Christina F. , Niemeyer Glenn P. , Werner Bonnie J. , Bean Christopher J. , Johnson Jeffrey A. , Hoffmaster Alex R. , Satheshkumar Panayampalli S. , Schuh Amy J. , Owen S. Michele , Thornburg Natalie J. 
Published: June 2022

Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) is a novel human coronavirus that was identified in 2019. SARS-CoV-2 infection results in an acute, severe respiratory disease called coronavirus disease 2019 (COVID-19). The emergence and rapid spread of SARS-CoV-2 has led to a global public health crisis, which continues to affect populations across the globe. Real time reverse transcription polymerase chain reaction (RT-PCR) is the reference standard test for COVID-19 diagnosis. Serological tests are valuable tools for serosurveillance programs and establishing correlates of protection from disease. This study evaluated the performance of one in-house enzyme linked immunosorbent assay (ELISA) utilizing the pre-fusion stabilized ectodomain of SARS-CoV-2 spike (S), two commercially available chemiluminescence assays Ortho VITROS Immunodiagnostic Products Anti-SARS-CoV-2 Total Reagent Pack and Abbott SARS-CoV-2 IgG assay and one commercially available Surrogate Virus Neutralization Test (sVNT), GenScript USA Inc., cPass SARS-CoV-2 Neutralization Antibody Detection Kit for the detection of SARS-CoV-2 specific antibodies. Using a panel of RT-PCR confirmed COVID-19 patients’ sera and a negative control group as a reference standard, all three immunoassays demonstrated high comparable positivity rates and low discordant rates. All three immunoassays were highly sensitive with estimated sensitivities ranging from 95.4%-96.6%. ROC curve analysis indicated that all three immunoassays had high diagnostic accuracies with area under the curve (AUC) values ranging from 0.9698-0.9807. High positive correlation was demonstrated among the conventional microneutralization test (MNT) titers and the sVNT inhibition percent values. Our study indicates that independent evaluations are necessary to optimize the overall utility and the interpretation of the results of serological tests. Overall, we demonstrate that all serological tests evaluated in this study are suitable for the detection of SARS-CoV-2 antibodies.
Polyalanine disease mutations impair UBA6-dependent ubiquitination
Authors: Amer-Sarsour Fatima , Falik Daniel , Berdichevsky Yevgeny , Kordonsky Alina , Prag Gali , Vatine Gad D , Ashkenazi Avraham 
Published: June 2022

AbstractExpansion mutations in polyalanine stretches are now associated with a growing number of human diseases with common genotypes and similar phenotypes 1–6. These similarities prompted us to query the normal function of physiological polyalanine stretches, and investigate whether a common molecular mechanism is involved in these diseases. Here, we show that UBA6, an E1 ubiquitin-activating enzyme 7, 8, recognizes a polyalanine stretch within its cognate E2 ubiquitin-conjugating enzyme, USE1. Aberrations in this polyalanine stretch reduced ubiquitin transfer to USE1 and downstream target, the E3 ubiquitin ligase, E6AP. Intriguingly, we identified competition for the UBA6-USE1 interaction by various proteins with polyalanine expansion mutations in the disease state. In mouse primary neurons, the deleterious interactions of expanded polyalanine proteins with UBA6, alter the levels and ubiquitination-dependent degradation of E6AP, which in turn affected the levels of the synaptic protein, Arc. These effects could be observed in induced pluripotent stem cell-derived autonomic neurons from patients with polyalanine expansion mutations. Our results suggest a shared mechanism for such mutations, which may contribute to the congenital malformations seen in polyalanine diseases.
Two major epidemics of highly pathogenic avian influenza virus H5N8 and H5N1 in domestic poultry in France, 2020-2022
Authors: Lambert Sébastien , Durand Benoit , Andraud Mathieu , Delacourt Roxane , Scoizec Axelle , Bouquin Sophie Le , Rautureau Séverine , Bauzile Billy , Guinat Claire , Fourtune Lisa , Guérin Jean-Luc , Paul Mathilde C. , Vergne Timothée 
Published: June 2022

SummaryThe spread of highly pathogenic avian influenza (HPAI) viruses worldwide has serious consequences for animal health and a major economic impact on the poultry production sector. Since 2014, Europe has been severely hit by several HPAI epidemics, with France being the most affected country. Most recently, France was again affected by two devastating highly pathogenic avian influenza epidemics in 2020-21 and 2021-22. We conducted a descriptive analysis of the 2020-21 and 2021-22 epidemics, in a first step towards identifying the poultry sector’s remaining vulnerabilities regarding HPAI viruses in France. We examined the spatio-temporal distribution of outbreaks that occurred in France in 2020-21 and 2021-22, and we assessed the outbreaks’ spatial distribution in relation to two High-Risk Zones recently incorporated into French legislation to strengthen HPAI prevention and control. There were 468 reported outbreaks during the 2020-21 epidemic, and 1,223 outbreaks during the 2021-22 epidemic. In both epidemics, most outbreaks (80.6% and 74.0%) were located into the two High-Risk Zones. The southwestern High-Risk Zone was affected in both epidemics, while the western High-Risk Zone was affected for the first time in 2021-22, explaining the extremely high number of outbreaks reported. We showed that the spatial distribution model used to create the two High-Risk Zones was able to predict the location of outbreaks for the 2020-21 and 2021-22 epidemics. These zones were characterized by high poultry farm densities; future efforts should therefore focus on reducing the density of susceptible poultry in highly dense areas.
Corrosion behavior of Al/TiO2/Y2O3hybrid nanocomposites manufactured using the vacuum-assisted stir casting route
Authors: Singh Mandeep , Bhandari Deepak , Goyal Khushdeep 
Published: June 2022

PurposeThis study aims to examine the corrosion and flexural behaviour of advanced hybrid aluminium matrix nanocomposites (HAMNCs) made with a vacuum-assisted stir die casting (two-layer feeding) and reinforced with titanium oxide (TiO2) and yttrium oxide (Y2O3) nanoparticles. The previous researchers have shown that TiO2and Y2O3nanoparticles make aluminium composites much more resistant to corrosion and wear.Design/methodology/approachSalt spray corrosion tests were done on the samples over time as well as the pre-and post-corrosion morphology of the test samples was also investigated. The density, porosity and energy dispersive X-ray of the fabricated samples were observed.FindingsIt was observed that a lower corrosion rate of 0.127 mils/year and 0.573 mils/year was seen in the Al/5 Wt.%TiO2/5 Wt.%Y2O3(HAMNC1) and Al/7.5 Wt.%TiO2/2.5 Wt.%Y2O3(HAMNC3), respectively. It was evident from the results that the pores and densities of the samples varied with the filler concentrations and matrix filler wettability. HAMNC1 has the lowest values of density and porosity at 2.568 g/cm3and 9.91%, respectively. At the same time, a significant improvement in the flexural strength of 72 N/mm2was also seen in the HAMNC1 configuration.Practical implicationsThe proposed hybrid samples are well suited for aerospace and automobile structural components such as brake drums, discs, engine cylinders and fins.Originality/valueThe mixed influence evaluation of TiO2and Y2O3nanoparticles with pure Al on composite samples has not been studied. This research aims to examine the combined influence of nanoparticles on the corrosion aspects of two-step feeding vacuum stir casted products, as well as their morphology.
Organic food and Instagram health and wellbeing influencers: an emerging country's perspective with gender as a moderator
Authors: Chetioui Youssef , Butt Irfan , Fathani Anass , Lebdaoui Hind 
Published: June 2022

PurposeInstagram health and wellbeing influencers (HWIs) have been increasingly considered as important sources of information and advice for their followers. This study aims to investigate the key antecedents of followers' attitude towards HWIs as well as their influence on their followers' intent to purchase organic products. The moderating effect of gender is also taken into account.Design/methodology/approachBased on data collected from 251 Instagram HWIs followers, the authors empirically tested the conceptual model using structural equation modeling.FindingsFirst, the authors demonstrate that attitude towards HWIs positively impacts followers' attitude towards the promoted brands as well as their intention to purchase organic food brands. Second, followers' attitude towards HWIs is mainly influenced by perceived congruence, influencer credibility, and physical attractiveness. Finally, gender acts as a moderator, e.g. attitude towards HWIs is more likely to be influenced by perceived congruence and physical attractiveness among female followers.Practical implicationsThe findings allow organic brands' managers to understand the key antecedents of followers' attitudes toward HWIs, and therefore, better select talented influencers who are able to create purchase intentions among both existing and potential customers.Originality/valueThis original research bridges a gap pertaining to the potential use of HWIs to shape consumer intention to purchase organic products. To the authors' knowledge, this study is the first of its kind to investigate the impact of attitudes toward influencers on both brand attitude and purchase intention in the organic food industry.
Founder domination, industry environment, and family firms' earnings management
Authors: Zhong Xi , Ren Liuyang , Wu XiaoJie 
Published: June 2022

PurposeBased on socioemotional wealth theory, the authors explore the impact of founder domination (with the founder as the chairman or CEO) on the earnings management activities of family firms and examine the moderating effect of the industry environment on the above relationship.Design/methodology/approachBased on the multivariate regression model, the authors test the theoretical view on the empirical data of Chinese family-owned listed companies.FindingsThe authors propose and find that under founder domination, family firms are unlikely to engage in earnings management activities. Furthermore, the authors find that industry growth enhances the above relationship, while industry competition weakens it.Originality/valueFirst, by clarifying the importance and heterogeneous impacts of the founder serving as chairman or CEO on China's family firms' earnings management, this research contributes to a fuller understanding of the impact of founder domination on the business activities of firms, especially family firms. Second, the authors contribute to the literature that examines the antecedents of earnings management, particularly in family firms. Third, the authors contribute to the study of the boundary conditions of the “founder domination-firms’ business activities” framework.
Impact of supervisory delegation on employee voice behavior: role of felt obligation for constructive change and voice climate
Authors: Rubbab Um-e , Naqvi Sayyed Muhammad Mehdi Raza , Irshad Muhammad , Zakariya Ramsha 
Published: June 2022

Purpose
The research linking organizational change-oriented activities with employee voice behavior is still in its initial stages. This study aims to contribute to this line of research by proposing felt obligation for constructive change, an underlying mechanism through which supervisory delegation enhances teachers’ voice behavior.

Design/methodology/approach
This study tested the interactive effect of felt obligation for constructive change and voice climate on teachers’ voice behavior. The proposed model is supported by proactive motivation theory which states that environmental factors lead to motivational states which further result in employee proactive behaviors. In this study, 415 teachers with their 74 supervisors (head of departments) from educational institutes completed the surveys. Structural equation modeling was used to find the results.

Findings
The results supported the mediation and moderation hypotheses, which proved that felt obligation for constructive change mediates the relationship between supervisory delegation and teachers’ voice behavior, and voice climate moderates the relationship between felt obligation for constructive change and teacher voice behavior.

Practical implications
This paper will provide an insight to the practitioners about the role of supervisory delegation for engagement in employee voice. This paper will also help managers understand that the workplace effectiveness can be enhanced by creating opportunities for employees to voice their concern.

Originality/value
This study recommends that head of departments at the workplace should cultivate an environment that is conducive for their faculty for engaging in voice behavior for improved functioning of educational institutes. Findings provide an insightful approach on organizational strategies in the form of supervisory delegation to trigger voice behavior among employees to meet the uncertainty of the ever-changing business environment.