bluuebunny/crossref_metadata_2025_split huggingface dataset:
Respiratory chain complex I is related to oxidative phosphorylation in gastric cancer stem cells
Authors: Peng Chunwei , Kang Weibiao , Li Yunsong 
Published: April 2022

Background: Cancer stem cells (CSCs) are the main cause of resistance to anti-cancer drug therapy and distant metastasis of tumors, including gastric cancer. The metabolism of CSCs is an important factor in the maintenance of its stemness. This study is intended to explore the role of oxidative phosphorylation in gastric CSCs.
Methods: EpCAM+CD44+ gastric CSCs were sorted from the SGC-7901 cell line. The oxidative phosphorylation and glycolysis were determined by Seahorse experiment, and the oxygen consumption of cells was determined by Clark’s oxygen electrodes. Gene expression and protein levels of mitochondrial proteins belonging to five respiratory chain complexes were checked. Phenformin and siRNA-NDUFB8 were used to inhibit respiratory chain complex I to explore the biological effect of enhanced oxidation phosphorylation in gastric CSCs. Cell migration capacity, proliferation ability, and vascular endothelial growth factor (VEGF) levels were also evaluated.
Results: Compared with control cells, the oxidation phosphorylation in mitochondria increased in EpCAM+CD44+ gastric CSCs, although the respiration level remained the same, and no significant changes were observed in glycolysis. Moreover, mRNA and protein expression levels of NDUFB8 in complex I were significantly increased. However, oxidative phosphorylation decreased in EpCAM+CD44+ cells after the treatment of phenformin and siRNA-NDUFB8 compared to the untreated cells. siRNA for NDFUB8 and phenformin inhibition also decreased the ability of cell migration, cell proliferation, as well as the VEGF secretion of gastric CSCs.
Conclusion: These results suggest that the increased oxidative phosphorylation was related to respiratory chain complex I and NDUFB8 in gastric CSCs.
HIPERSENSIBILIDADE AO NÍQUEL E O APARELHO ORTODÔNTICO: ASPECTOS BIOLÓGICOS E CLÍNICOS
Authors: De Azevedo Monarko Nunes , Vêncio Eneida Franco , Lenza Marcos Augusto 
Published: April 2022

O níquel é um elemento responsável por até 17% dos casos de hipersensibilidade em pacientes sob tratamento ortodôntico. Apesar de ser uma preocupação recorrente, não há um consenso sobre a influência das taxas de níquel, liberadas dos aparelhos ao longo do tratamento ortodôntico, e da resposta imune inflamatória capazes de causar reações alérgicas ao paciente. O objetivo do presente estudo é apresentar uma revisão da literatura sobre os aspectos biológicos e clínicos envolvidos nas reações de hipersensibilidade ao níquel durante o tratamento ortodôntico. A coleta de dados ocorreu por meio de busca bibliográfica, nas seguintes bases de dados: Pubmed, Periódicos Capes, BVS e SciELO, utilizando os descritores “Ortodontia corretiva”, “Hipersensibilidade tardia”, e “Níquel”. Foram selecionados 128 trabalhos publicados entre 1929 a 2019. Considerando que a utilização de dispositivos metálicos é muito frequente dentro da Ortodontia, os autores abordam quais são as implicações do uso de aparelhos com níquel na prática clínica do ortodontista. Em seguida, apresentam um dos principais problemas causados pelo íon níquel: a hipersensibilidade. Por fim, são discutidos os aspectos epidemiológicos e fatores de risco da doença, como ela se desenvolve, como se manifesta, através dos sinais e sintomas, nos indivíduos alérgicos e como é realizado o diagnóstico e o melhor tratamento para as reações. Os resultados do presente estudo podem ajudar a desenvolver estratégias eficientes e seguras para a prevenção e o tratamento dessa condição, além de contribuir para uma conduta adequada durante a terapia ortodôntica dos indivíduos.
EDUCATION DINIYAH POLICY IN THE SCOPE OF AL-BAROKAH ISLAMIC BOARDING SCHOOL DURING THE COVID-19 PANDEMIC
Authors: Arifin Muhammad Bustanul , Firmansyah Firmansyah , Sahrandi Akhmad 
Published: April 2022

Abstract
Diniyah education in Islamic boarding schools is a program that must be undercontrolled and further improved both in quality and quantity, in order to improve the students attention in studying for their future. To accomplish that goal, we need supporting factors such as diniyah, Al-quran readings, bandongan, sorogan and the role of ustadz as mentors as guides and role models for students. The purpose of this research is to increase the investment of the excellent children, have good character and morality, broad -minded by bringing Islamic values, salaf as exemplified by previous scholars.
This research uses qualitative methods based on real theories. it uses observation techniques to observe the surrounding conditions, especially within the scope of the Islamic boarding school. The expected results of this study are: 1) existing policies in madrasah diniyah are run properly to accommodate children who in the future continue the relay of the struggle of the previous leader, who have good morality, noble character, based on the values of Islamic teachings. Policies in the diniyah may be different from before because this country is still struggling from the covid virus which has not ended until to day.
Signatures of a Surviving Helium-star Companion in Type Ia Supernovae and Constraints on the Progenitor Companion of SN 2011fe
Authors: Liu Zheng-Wei , Röpke Friedrich K. , Zeng Yaotian 
Published: April 2022

Abstract
Single-degenerate (SD) binary systems composed of a white dwarf and a nondegenerate helium (He)-star companion have been proposed as the potential progenitors of Type Ia supernovae (SNe Ia). The He-star companions are expected to survive the SN Ia explosion in this SD progenitor model. In the present work, we map the surviving He-star companion models computed from our previous three-dimensional hydrodynamical simulations of ejecta–companion interaction into the one-dimensional stellar evolution code Modules for Experiments in Stellar Astrophysics to follow their long-term evolution to make predictions of their post-impact observational properties, which can be helpful in searches for such surviving He-star companions in future observations. By comparing with the very-late-epoch light curve of the best observed SN Ia, SN 2011fe, we find that our surviving He-star companions become significantly more luminous than SN 2011fe about 1000 days after maximum light. This suggests that an He star is very unlikely to be a companion to the progenitor of SN 2011fe.
Photometric Analysis of the OGLE Heartbeat Stars
Authors: Wrona Marcin , Kołaczek-Szymański Piotr A. , Ratajczak Milena , Kozłowski Szymon 
Published: April 2022

Abstract
We present an analysis of 991 heartbeat stars (HBSs) from the OGLE Collection of Variable Stars. The sample consists of 512 objects located toward the Galactic bulge, 439 in the Large Magellanic Cloud, and 40 in the Small Magellanic Cloud. We model the I-band OGLE light curves using an analytical model of flux variations reflecting tidal deformations between stars. We present distributions of the model parameters that include the eccentricity, orbital inclination, and argument of the periastron but also the period–amplitude diagrams. On the Hertzsprung–Russell diagram, our HBS sample forms two separate groups of different evolutionary status. The first group, including about 90 systems with short orbital periods (P ≲ 50 days), consists of an early-type primary star lying on (or close to) the main sequence. The second group, including about 900 systems with long orbital periods (P ≳ 100 days), contains a red giant (RG). The position of the RG HBSs on the period–luminosity diagram strongly indicates their binary nature. They appear to be a natural extension of confirmed binary systems that include the OGLE ellipsoidal and long secondary period variables. We also present a time-series analysis leading to detection of tidally excited oscillations (TEOs). We identify such pulsations in about 5% of stars in the sample with a total of 78 different modes. This first relatively large homogeneous sample of TEOs allowed us to construct a diagram revealing the correlation between the TEO’s orbital harmonic number and the eccentricity of the host binary system.
Testing the Alfvén-wave Model of the Solar Wind with Interplanetary Scintillation
Authors: Shoda Munehito , Iwai Kazumasa , Shiota Daikou 
Published: April 2022

Abstract
Understanding the mechanism(s) of solar wind acceleration is important in astrophysics and geophysics. A promising model of solar wind acceleration is known as the wave/turbulence-driven (WTD) model, in which Alfvén waves feed energy to the solar wind. In this study, we tested the WTD model with global measurements of wind speed from interplanetary scintillation (IPS) observations. For Carrington rotations in minimal and maximal activity phases, we selected field lines calculated by the potential-field source-surface method in high and midlatitudes and compared the simulated and observed wind velocities. The simulation was performed in a self-consistent manner by solving the magnetohydrodynamic equations from the photosphere to the solar wind. In high-latitude regions, the simulated solar wind velocity agrees better with the IPS observation than with the classical Wang–Sheeley empirical estimation, both in maximal and minimal activity phases. In midlatitude regions, the agreement worsens, possibly because of the inaccuracy of the WTD model and/or the magnetic-field extrapolation. Our results indicate that the high-latitude solar wind is likely to be driven by waves and turbulence and that the physics-based prediction of the solar wind velocity is highly feasible with an improved magnetic-field extrapolation.
Winter Weakening of Titan's Stratospheric Polar Vortices
Authors: Shultis J. , Waugh D. W. , Toigo A. D. , Newman C. E. , Teanby N. A. , Sharkey J. 
Published: April 2022

Abstract
Polar vortices are a prominent feature in Titan's stratosphere. The Cassini mission has provided a detailed view of the breakdown of the northern polar vortex and formation of the southern vortex, but the mission did not observe the full annual cycle of the evolution of the vortices. Here we use a TitanWRF general circulation model simulation of an entire Titan year to examine the full annual cycle of the polar vortices. The simulation reveals a winter weakening of the vortices, with a clear minimum in polar potential vorticity and midlatitude zonal winds between winter solstice and spring equinox. The simulation also produces the observed postfall equinox cooling followed by rapid warming in the upper stratosphere. This warming is due to strong descent and adiabatic heating, which also leads to the formation of an annular potential vorticity structure. The seasonal evolution of the polar vortices is very similar in the two hemispheres, with only small quantitative differences that are much smaller than the seasonal variations, which can be related to Titan's orbital eccentricity. This suggests that any differences between observations of the northern hemisphere vortex in late northern winter and the southern hemisphere vortex in early winter are likely due to the different observation times with respect to solstice, rather than fundamental differences in the polar vortices.
L’évolution démographique récente de la France
Authors: Breton Didier , Belliot Nicolas , Barbieri Magali , d’Albis Hippolyte , Mazuy Magali 
Published: April 2022

Le 1 er janvier 2021, la France comptait 67,4 millions d’habitants soit 120 000 de plus qu’au 1 er janvier 2020. Contrairement à de nombreux pays européens, la population de la France n’a pas diminué, mais marque un très fort ralentissement, du fait principalement de la crise sanitaire engendrée par la pandémie de Covid qui a eu des effets sur toutes les composantes démographiques. Les données provisoires indiquent en 2020 une diminution du nombre de titres de séjours d’au moins un an délivrés à des personnes des pays tiers (– 10 000), notamment ceux en provenance de pays d’Afrique et ceux pour cause « familiale » et « humanitaire ». Le nombre de naissances a également fortement baissé, particulièrement 9 mois après le confinement. Cette baisse s’explique par une diminution de nombre de conceptions et non une augmentation des interruptions volontaires de grossesses qui sont en recul, notamment les mois suivant le premier confinement. Mais les deux phénomènes les plus fortement affectés sont, d’une part, les mariages rendus impossibles du fait des règles sanitaires (– 70 000) et, comme on pouvait s’y attendre, la mortalité avec une diminution de l’espérance de vie de 0,56 an pour les hommes et 0,45 an pour les femmes, soit un retour au niveau de mortalité observé 6 ans auparavant.
Distinct Cellular Immune Responses to SARS-CoV-2 in Pregnant Women
Authors: Gomez-Lopez Nardhy , Romero Roberto , Tao Li , Gershater Meyer , Leng Yaozhu , Zou Chengrui , Farias-Jofre Marcelo , Galaz Jose , Miller Derek , Tarca Adi L , Arenas-Hernandez Marcia , Bhatti Gaurav , Garcia-Flores Valeria , Liu Zhenjie , Para Robert , Kanninen Tomi , Hadaya Ola , Paredes Carmen , Xu Yi 
Published: April 2022

Abstract
Pregnant women are at increased risk of adverse outcomes, including preeclampsia and preterm birth, that may result from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Pregnancy imprints specific maternal immune responses that can modulate host susceptibility to microbial infection; therefore, recent studies have focused on the humoral response against SARS-CoV-2 in pregnant women. However, the pregnancy-specific cellular immune responses triggered by SARS-CoV-2 infection are poorly understood. In this study, we undertook an extensive in vitro investigation to determine the cellular immune responses to SARS-CoV-2 particles and proteins/peptides in pregnant women. First, we show that SARS-CoV-2 particles do not alter the pregnancy-specific oxidative burst of neutrophils and monocytes. Yet, SARS-CoV-2 particles/proteins shift monocyte activation from the classical to intermediate states in pregnant, but not in nonpregnant, women. Furthermore, SARS-CoV-2 proteins, but not particles or peptide pools, mildly enhance T cell activation during pregnancy. As expected, B cell phenotypes are heavily modulated by SARS-CoV-2 particles in all women; yet, pregnancy itself further modified such responses in these adaptive immune cells. Lastly, we report that pregnancy itself governs cytokine responses in the maternal circulation, of which IFN-β and IL-8 were diminished upon SARS-CoV-2 challenge. Collectively, these findings highlight the differential in vitro responses to SARS-CoV-2 in pregnant and nonpregnant women and shed light on the immune mechanisms implicated in coronavirus disease 2019 during pregnancy.
Interaction of Cry1 Gene Polymorphisms and Dominant Food Patterns on Obesity
Authors: Tangestani Hadith , Emamat Hadi , Yekaninejad Mir Saeed , Alipour Mohsen , Keshavarz Seyed Ali , Mirzaei Khadijeh 
Published: April 2022

Background:
Evidence suggests that there is some relationship between circadian clock gene variants and obesity. However, there are few examinations supporting this observation in human subjects. This study was aimed to investigate the interaction between Cry1 circadian gene polymorphism and major dietary patterns on obesity measurements.

Methods:
Healthy overweight and obese women aged 18–53 years old were recruited from health centers in Tehran, Iran by a multistage cluster random sampling method (n = 377). Major dietary patterns were elicited after assessing the intake of 16 food groups using a valid and reliable 147-item food frequency questionnaire (FFQ). Anthropometric measurements were performed for each and every participant. Body composition was analyzed using bioelectrical impedance analysis (BIA). Socio-demographic and physical activity data were also collected by a validated Farsi demographic questionnaire and the international physical activity questionnaire (IPAQ). The Cry1 rs2287161 polymorphism were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Generalized linear models were used for interaction analysis.

Results:
Two major dietary patterns, including healthy and unhealthy dietary pattern (HDP and UDP, respectively) were determined using factor analysis. Our study showed a significant higher weight (P = 0.003), body mass index (BMI) (P = 0.042), hip circumference (P = 0.052), and body fat mass (P = 0.028) in carriers of C allele compared with G allele. Moreover, a significant gene-diet interaction was observed between being a carrier of C allele and BMI (P = 0.099 for CC genotype; P = 0.1 for CG genotype) and fat mass (P = 0.1 for CG genotype).

Conclusions:
The current study suggests a significant interaction of Cry1 rs2287161 gene polymorphisms in people following a healthy dietary pattern on BMI and fat mass among carriers of C allele compared to carriers of G allele.
Use of Complementary and Alternative Medicine Among Patients on Long Term Treatment in a Tertiary Health Institution in Jos Nigeria
Authors: Afolaranmi Tolulope O. , Hassan Zuwaira I. , Uwadiae Esosa J. , Nwokolo Uchechukwu E. , Nwaemelu Ijeoma B. , Ugwu Kainechukwu G. , Ugwu Obinna J. , Bello Kayode K. , Ofakunrin Akinyemi O. 
Published: April 2022

Background:
The use of Complementary and Alternative Medicine (CAM) is on the increase globally and found to be more pronounced among those with chronic illnesses even in the face of insufficient scientific evidence to support its efficacy. Hence, this study was conducted to assess the level of use of CAM and its predictors among patients on long term care in tertiary health institution.

Methods:
This was a cross-sectional study conducted among 176 patients accessing treatment for chronic medical conditions in Jos University Teaching Hospital using quantitative method of data collection. Epi Info statistical software version 7 was used for data analysis and a value of P < 0.05 was considered statistically significant.

Results:
The median age of respondents was 50 (IQR 30–84) years with 83 (47.2%) being 51 years and above. Utilization of CAM was reported among 72 (40.9%) with herbal preparation ranking highest among 56 (77.8%) the respondents. Absence of side effects (AOR = 2.23; 95% CI = 1.6918–3.2135) and consistency with culture (AOR = 4.46; 95% CI = 1.4695–6.1851) were identified predictors of CAM use.

Conclusions:
This study has demonstrated a relatively high level of CAM use with perceived absence of side effects, peer influence, and consistency with culture predicting its use.
Pretravelling Health-Seeking Behavior, Knowledge of Vaccines, and Attitudes Toward Travel Health among Malaysian Travelers
Authors: B. Sidek Ahmad Zulkhairul Naim , Zarkasi Khairul Anwar , Ramli Nur Zuliani , Che Jamaludin Farrah Ilyani , Che Hasan Muhammad Kamil 
Published: April 2022

Background:
Travelers are at higher risk of developing health-related problems, especially travel-related diseases, and this remains a major public health burden.

Aims:
To assess pretravel health behavior-seeking factors, knowledge of vaccine, and travel health attitudes. A cross-sectional design among Malaysian travelers.

Methods:
An online survey was conducted from December 2017 till March 2018 among 226 participants. Demographic data, pretraveling health behaviors, knowledge of vaccine-preventable diseases, and travel health were asked. Independent t-test and ANOVA were performed using SPSS version 20.

Results:
Among travelers, 51.3% and 63.7% used health-related information on their destination before departure and collected information on possible travel hazards at their destination. Participant age (P = 0.02), monthly income (P = 0.01), predeparture health information (P = 0.03), information on possible hazards (P = 0.04), and travel health advice from medical professionals (P = 0.03) have been reported as a major predictor of knowledge of vaccine-preventable disease. Travelers’ gender (P = 0.01), household income (P = 0.01), and travel health advice from professionals (P = 0.002) were significantly associated with travel health attitude.

Conclusions:
Sociodemographic and pretravel health-seeking behavior influence knowledge of vaccine-preventable disease and attitudes towards travel health which requires a public health need for community outreach programs targeting this group.
Effectiveness of Topical 0.5% Ivermectin Shampoo in the Treatment of Pediculosis Capitis among School-going Female Children
Authors: Karthikeyan Kaliaperumal , Aishwarya Manju , Elayaperumal Suguna 
Published: April 2022

Background:
Pediculosis is a common ectoparasitic infestation in children. There are different treatment modalities that have been used in the treatment of pediculosis capitis from time immemorial, each with their own shortcomings. Increasing emergence of resistance to permethrin has led to the lookout for newer alternatives.

Aims and Objectives:
The role of topical ivermectin in the management of pediculosis in people with culturally different hair grooming practices is analyzed in this study.

Materials and Methods:
This observational open-label clinical study was conducted in September–November 2019 in the schools that were under the rural health center at South India among school-going female children aged between 13 and 16 years of age and diagnosed with pediculosis.

Results:
This study demonstrated that a single application of ivermectin shampoo was able to kill head lice in 86.2% of the participants. In participants with persistent infection (13.8%), a repeat application killed the entire louse and 100% efficacy was demonstrated. Topical ivermectin is devoid of systemic side effects of oral ivermectin. Topical ivermectin has found to be more effective than contemporary recommended agents such as malathion and permethrin.
Targeted Nutritional Supplementation for Telogen Effluvium
Authors: Arias Eva Maria , Floriach Nuria , Moreno-Arias Gerardo , Camps Alejandro , Arias Salvador , Trüeb Ralph Michel 
Published: April 2022

Background:
The condition of the hair is closely related to the nutritional state. Normal supply, uptake, and transport of nutrients are of fundamental importance in tissues with a high biosynthetic activity such as the hair follicle.

Objective:
The objective of the study was to evaluate the efficacy of a nutritional-based induction and maintenance treatment for telogen effluvium formulated with a combination of hydrolyzed collagen, amino acids, vitamins, and minerals.

Patients and Methods:
The clinical studies were conducted with each nutritional treatment individually, and both in sequential combination. Anagen/telogen ratio, hair density, and tolerability of treatment were assessed at baseline, 4 weeks of induction therapy, and another 12 weeks of maintenance treatment. Trichogram results showed a significant improvement of the anagen/telogen ratio between baseline and final visit at 16 weeks, with an increase of hair in anagen and a reduction of hair in telogen. Furthermore, a significant increase was observed in hair density. The effect size of the combination treatment was higher than that of each of the two products used separately as monotherapy.

Conclusions:
The study results provide a proof of concept for targeted nutritional supplementation for the treatment of telogen effluvium, with a special emphasis on the role of collagen, besides specific amino acids, vitamins, and minerals.
Statistical corner
Authors: Pyysalo Mikko 
Published: April 2022

Introduction:
R is a programming language that can be used to efficiently solve statistical problems.

Objectives:
To demonstrate the method of building functions using R in statistical analysis and storing it for future use.

Materials and Methods:
A real world example of comparison of statistical values in aneurysm research with respect to its locations has been used to demonstrate how one might build a function using R.

Results:
Accurate results could be obtained and the function can be stored for later use.

Conclusions:
As the statistical tools required in research are recurrent, building functions in R and storing them for future use is highly recommended.