bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiographic Controls and Wildfire Effects on Aquatic Biogeochemistry in Tundra of the Yukon‐Kuskokwim Delta, Alaska
Authors: Zolkos Scott , MacDonald Erin , Hung Jacqueline K. Y. , Schade John D. , Ludwig Sarah , Mann Paul J. , Treharne Rachael , Natali Susan 
Published: July 2022

AbstractNorthern high‐latitude deltas are hotspots of biogeochemical processing, terrestrial‐aquatic connectivity, and, in Alaska's Yukon‐Kuskokwim Delta (YKD), tundra wildfire. Yet, wildfire effects on aquatic biogeochemistry remain understudied in northern delta regions, thus limiting a more comprehensive understanding of high latitude biogeochemical cycles. In this study, we assess wildfire impacts on summertime aquatic biogeochemistry in YKD tundra using a multi‐year (2015–2019) data set of water chemistry measurements (n = 406) from five aquatic environments: peat plateau ponds, fen ponds, fen channels, lakes, and streams. We aimed to (a) characterize variation in hydrochemistry among aquatic environments; (b) determine wildfire effects on hydrochemistry; and (c) assess post‐fire multi‐year patterns in hydrochemistry in lakes (lower terrestrial‐freshwater connectivity) and fen ponds (higher connectivity). Variation in hydrochemistry among environments was more strongly associated with watershed characteristics (e.g., terrestrial‐aquatic connectivity) than wildfire. However, certain hydrochemical constituents showed consistent wildfire effects. Decreases in dissolved organic carbon (DOC) and CO2, and increases in pH, specific conductance, NH4+, and NO3− indicate that, by combusting soil organic matter, wildfire reduces organics available for hydrologic transport and microbial respiration, and mobilizes nitrogen into freshwaters. Multi‐year post‐fire variation in specific conductance, DOC, and CO2 in lakes and fen ponds suggest that watershed characteristics underlie ecosystem response and recovery to wildfire in the YKD. Together, these results indicate that increasing tundra wildfire occurrence at northern high latitudes could drive multi‐year shifts toward stronger aquatic inorganic nutrient cycling, and that variation in terrain characteristics is likely to underlie wildfire effects on aquatic ecosystems across broader scales.
Observation of polarity-switchable photoconductivity in III-nitride/MoSx core-shell nanowires
Authors: Wang Danhao , Wu Wentiao , Fang Shi , Kang Yang , Wang Xiaoning , Hu Wei , Yu Huabin , Zhang Haochen , Liu Xin , Luo Yuanmin , He Jr-Hau , Fu Lan , Long Shibing , Liu Sheng , Sun Haiding 
Published: July 2022

AbstractIII–V semiconductor nanowires are indispensable building blocks for nanoscale electronic and optoelectronic devices. However, solely relying on their intrinsic physical and material properties sometimes limits device functionalities to meet the increasing demands in versatile and complex electronic world. By leveraging the distinctive nature of the one-dimensional geometry and large surface-to-volume ratio of the nanowires, new properties can be attained through monolithic integration of conventional nanowires with other easy-synthesized functional materials. Herein, we combine high-crystal-quality III-nitride nanowires with amorphous molybdenum sulfides (a-MoSx) to construct III-nitride/a-MoSx core-shell nanostructures. Upon light illumination, such nanostructures exhibit striking spectrally distinctive photodetection characteristic in photoelectrochemical environment, demonstrating a negative photoresponsivity of −100.42 mA W−1 under 254 nm illumination, and a positive photoresponsivity of 29.5 mA W−1 under 365 nm illumination. Density functional theory calculations reveal that the successful surface modification of the nanowires via a-MoSx decoration accelerates the reaction process at the electrolyte/nanowire interface, leading to the generation of opposite photocurrent signals under different photon illumination. Most importantly, such polarity-switchable photoconductivity can be further tuned for multiple wavelength bands photodetection by simply adjusting the surrounding environment and/or tailoring the nanowire composition, showing great promise to build light-wavelength controllable sensing devices in the future.
Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineages
Authors: Xia Shuai , Wang Lijue , Zhu Yun , Lu Lu , Jiang Shibo 
Published: July 2022

AbstractRecently, a large number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continuously emerged and posed a major threat to global public health. Among them, particularly, Omicron variant (B.1.1.529), first identified in November 2021, carried numerous mutations in its spike protein (S), and then quickly spread around the world. Currently, Omicron variant has expanded into more than one hundred sublineages, such as BA.1, BA.2, BA.2.12.1, BA.4 and BA.5, which have already become the globally dominant variants. Different from other variants of concern (VOCs) of SARS-CoV-2, the Omicron variant and its sublineages exhibit increased transmissibility and immune escape from neutralizing antibodies generated through previous infection or vaccination, and have caused numerous re-infections and breakthrough infections. In this prospective, we have focused on the origin, virological features, immune evasion and intervention of Omicron sublineages, which will benefit the development of next-generation vaccines and therapeutics, including pan-sarbecovirus and universal anti-CoV therapeutics, to combat currently circulating and future emerging Omicron sublineages as well as other SARS-CoV-2 variants.
Long non-coding RNA DLEU1 promotes malignancy of breast cancer by acting as an indispensable coactivator for HIF-1α-induced transcription of CKAP2
Authors: Ma He Nan , Chen Hai Jun , Liu Ji Quan , Li Wen Tao 
Published: July 2022

AbstractEarlier studies have suggested deleted in lymphocytic leukemia 1 (DLEU1), a long non-coding RNA, is a prognostic biomarker for breast cancer. Here we explored the malignant behaviors and underlying mechanisms regulated by DLEU1 in breast cancer. We demonstrated that up-regulation of DLEU1 was detected in breast cancer tissues and cells, particularly in tumors of higher malignancy. DLEU1 knockdown inhibited the growth and the motility of breast cancer cells. Mechanistically, DLEU1 interacted with HIF-1α to collectively activate the transcription of CKAP2. By activating ERK and STAT3 signaling, CKAP2 essentially mediated the pro-tumor activities of DLEU1. In vivo, depletion of DLEU1 inhibited xenograft growth and metastasis of breast cancer cells. Therefore, DLEU1, by acting as a coactivator for HIF-1α, up-regulates CKAP2 expression and promotes malignancy of breast cancer. Targeting DLEU1, HIF-1α, or CKAP2 may thus benefit breast cancer treatment.
Drought-Induced Civil Conflict Among the Ancient Maya
Authors: Kennett Douglas J. , Masson Marilyn , Lope Carlos Peraza , Serafin Stanley , George Richard J. , Spencer Tom C. , Hoggarth Julie A. , Culleton Brendan J. , Harper Thomas K. , Prufer Keith M. , Milbrath Susan , Russell Bradley W. , González Eunice Uc , McCool Weston C. , Aquino Valorie V. , Paris Elizabeth H. , Curtis Jason H. , Marwan Norbert , Zhang Mingua , Asmerom Yemane , Polyak Victor J. , Carolin Stacy A. , James Daniel H. , Mason Andrew J. , Henderson Gideon M. , Brenner Mark , Baldini James U. L. , Breitenbach Sebastian F. M. , Hodell David A. 
Published: July 2022

AbstractThe influence of climate change on civil conflict and societal instability in the premodern world is a subject of much debate, in part because of the limited temporal or disciplinary scope of case studies. We present a transdisciplinary case study that combines archeological, historical, and paleoclimate datasets to explore the dynamic, shifting relationships among climate change, civil conflict, and political collapse at Mayapan, the largest Postclassic Maya capital of the Yucatán Peninsula in the thirteenth and fourteenth centuries CE. Multiple data sources indicate that civil conflict increased significantly and generalized linear modeling correlates strife in the city with drought conditions between 1400 and 1450 cal. CE. We argue that prolonged drought escalated rival factional tensions, but subsequent adaptations reveal regional-scale resiliency, ensuring that Maya political and economic structures endured until European contact in the early sixteenth century CE.
Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome
Authors: Fathi Anahita , Dahlke Christine , Krähling Verena , Kupke Alexandra , Okba Nisreen M. A. , Raadsen Matthijs P. , Heidepriem Jasmin , Müller Marcel A. , Paris Grigori , Lassen Susan , Klüver Michael , Volz Asisa , Koch Till , Ly My L. , Friedrich Monika , Fux Robert , Tscherne Alina , Kalodimou Georgia , Schmiedel Stefan , Corman Victor M. , Hesterkamp Thomas , Drosten Christian , Loeffler Felix F. , Haagmans Bart L. , Sutter Gerd , Becker Stephan , Addo Marylyn M. 
Published: July 2022

AbstractVaccine development is essential for pandemic preparedness. We previously conducted a Phase 1 clinical trial of the vector vaccine candidate MVA-MERS-S against the Middle East respiratory syndrome coronavirus (MERS-CoV), expressing its full spike glycoprotein (MERS-CoV-S), as a homologous two-dose regimen (Days 0 and 28). Here, we evaluate the safety (primary objective) and immunogenicity (secondary and exploratory objectives: magnitude and characterization of vaccine-induced humoral responses) of a third vaccination with MVA-MERS-S in a subgroup of trial participants one year after primary immunization. MVA-MERS-S booster vaccination is safe and well-tolerated. Both binding and neutralizing anti-MERS-CoV antibody titers increase substantially in all participants and exceed maximum titers observed after primary immunization more than 10-fold. We identify four immunogenic IgG epitopes, located in the receptor-binding domain (RBD, n = 1) and the S2 subunit (n = 3) of MERS-CoV-S. The level of baseline anti-human coronavirus antibody titers does not impact the generation of anti-MERS-CoV antibody responses. Our data support the rationale of a booster vaccination with MVA-MERS-S and encourage further investigation in larger trials. Trial registration: Clinicaltrials.gov NCT03615911.
Microporous polymer adsorptive membranes with high processing capacity for molecular separation
Authors: Wang Zhenggong , Luo Xiaofan , Song Zejun , Lu Kuan , Zhu Shouwen , Yang Yanshao , Zhang Yatao , Fang Wangxi , Jin Jian 
Published: July 2022

AbstractTrade-off between permeability and nanometer-level selectivity is an inherent shortcoming of membrane-based separation of molecules, while most highly porous materials with high adsorption capacity lack solution processability and stability for achieving adsorption-based molecule separation. We hereby report a hydrophilic amidoxime modified polymer of intrinsic microporosity (AOPIM-1) as a membrane adsorption material to selectively adsorb and separate small organic molecules from water with ultrahigh processing capacity. The membrane adsorption capacity for Rhodamine B reaches 26.114 g m−2, 10–1000 times higher than previously reported adsorptive membranes. Meanwhile, the membrane achieves >99.9% removal of various nano-sized organic molecules with water flux 2 orders of magnitude higher than typical pressure-driven membranes of similar rejections. This work confirms the feasibility of microporous polymers for membrane adsorption with high capacity, and provides the possibility of adsorptive membranes for molecular separation.
α-Synuclein fibril-specific nanobody reduces prion-like α-synuclein spreading in mice
Authors: Butler Yemima R. , Liu Yuqing , Kumbhar Ramhari , Zhao Peiran , Gadhave Kundlik , Wang Ning , Li Yanmei , Mao Xiaobo , Wang Wenjing 
Published: July 2022

AbstractPathogenic α-synuclein (α-syn) is a prion-like protein that drives the pathogenesis of Lewy Body Dementia (LBD) and Parkinson’s Disease (PD). To target pathogenic α-syn preformed fibrils (PFF), here we designed extracellular disulfide bond-free synthetic nanobody libraries in yeast. Following selection, we identified a nanobody, PFFNB2, that can specifically recognize α-syn PFF over α-syn monomers. PFFNB2 cannot inhibit the aggregation of α-syn monomer, but can significantly dissociate α-syn fibrils. Furthermore, adeno-associated virus (AAV)-encoding EGFP fused to PFFNB2 (AAV-EGFP-PFFNB2) can inhibit PFF-induced α-syn serine 129 phosphorylation (pS129) in mouse primary cortical neurons, and prevent α-syn pathology spreading to the cortex in the transgenic mice expressing human wild type (WT) α-syn by intrastriatal-PFF injection. The pS129 immunoreactivity is negatively correlated with the expression of AAV-EGFP-PFFNB2. In conclusion, PFFNB2 holds a promise for mechanistic exploration and therapeutic development in α-syn-related pathogenesis.
Multiple valence bands convergence and strong phonon scattering lead to high thermoelectric performance in p-type PbSe
Authors: Zhu Yingcai , Wang Dongyang , Hong Tao , Hu Lei , Ina Toshiaki , Zhan Shaoping , Qin Bingchao , Shi Haonan , Su Lizhong , Gao Xiang , Zhao Li-Dong 
Published: July 2022

AbstractThermoelectric generators enable the conversion of waste heat to electricity, which is an effective way to alleviate the global energy crisis. However, the inefficiency of thermoelectric materials is the main obstacle for realizing their widespread applications and thus developing materials with high thermoelectric performance is urgent. Here we show that multiple valence bands and strong phonon scattering can be realized simultaneously in p-type PbSe through the incorporation of AgInSe2. The multiple valleys enable large weighted mobility, indicating enhanced electrical properties. Abundant nano-scale precipitates and dislocations result in strong phonon scattering and thus ultralow lattice thermal conductivity. Consequently, we achieve an exceptional ZT of ~ 1.9 at 873 K in p-type PbSe. This work demonstrates that a combination of band manipulation and microstructure engineering can be realized by tuning the composition, which is expected to be a general strategy for improving the thermoelectric performance in bulk materials.
Coastal ecological impacts from pumice rafts
Authors: Ohno Yoshikazu , Iguchi Akira , Ijima Mariko , Yasumoto Ko , Suzuki Atsushi 
Published: July 2022

AbstractAn explosive volcanic eruption occurred in the Ogasawara Islands on 13–15 August 2021, bringing unprecedented amounts of floating pumice to the coast of Okinawa Island in the Ryukyu Archipelago, 1300 km west of the volcano, approximately 2 months later. The coast of Okinawa Island, especially along the northern part, is home to many typical subtropical seascapes, including coral reefs and mangrove forests, so the possible impact of the large amount of pumice is attracting attention. Here, we report early evidence of ecosystem changes as a result of large-scale pumice stranding on coastal beaches, in estuaries and mangrove forests and passage across fringing coral reefs. Massive pumice drifts are major obstacles to fishing activities and ship traffic, but short and long-term changes in coastal ecosystems can also occur. The phenomena observed on Okinawa Island can be a preview of coastal impacts for the Kyushu, Shikoku, Honshu Islands, where pumice has subsequently washed ashore.
Effects of intermittent hypoxia with thrombin in an in vitro model of human brain endothelial cells and their impact on PAR-1/PAR-3 cleavage
Authors: Zolotoff Cindy , Puech Clémentine , Roche Frédéric , Perek Nathalie 
Published: July 2022

AbstractPatients with obstructive sleep apnea/hypopnea (OSA) are at high risk of cerebrovascular diseases leading to cognitive impairment. The oxidative stress generated by intermittent hypoxia (IH) could lead to an increase in blood–brain barrier (BBB) permeability, an essential interface for the protection of the brain. Moreover, in patients with OSA, blood coagulation could be increased leading to cardiovascular complications. Thrombin is a factor found increased in these populations that exerts various cellular effects through activation of protease activated receptors (PARs). Thus, we have evaluated in an in vitro BBB model the association of IH with thrombin at two concentrations. We measured the apparent BBB permeability, expression of tight junctions, ROS production, HIF-1α expression, and cleavage of PAR-1/PAR-3. Pre-treatment with dabigatran was performed. IH and higher thrombin concentrations altered BBB permeability: high levels of HIF-1α expression, ROS and PAR-1 activation compared to PAR-3 in such conditions. Conversely, lower concentration of thrombin associated with IH appear to have a protective effect on BBB with a significant cleavage of PAR-3. Dabigatran reversed the deleterious effect of thrombin at high concentrations but also suppressed the beneficial effect of low dose thrombin. Therefore, thrombin and PARs represent novel attractive targets to prevent BBB opening in OSA.
Borate-guided ribose phosphorylation for prebiotic nucleotide synthesis
Authors: Hirakawa Yuta , Kakegawa Takeshi , Furukawa Yoshihiro 
Published: July 2022

AbstractPolymers of ribonucleotides (RNAs) are considered to store genetic information and promote biocatalytic reactions for the proto life on chemical evolution. Abiotic synthesis of ribonucleotide was successful in past experiments; nucleoside synthesis occurred first, followed by phosphorylation. These abiotic syntheses are far from biotic reactions and have difficulties as a prebiotic reaction in reacting chemicals in a specific order and purifying intermediates from other molecules in multi-steps of reactions. Another reaction, ribose phosphorylation followed by nucleobase synthesis or nucleobase addition, is close to the biotic reactions of nucleotide synthesis. However, the synthesis of ribose 5′-phosphate under prebiotically plausible conditions remains unclear. Here, we report a high-yield regioselective one-pot synthesis of ribose 5′-phosphate from an aqueous solution containing ribose, phosphate, urea, and borate by simple thermal evaporation. Of note, phosphorylation of ribose before the nucleoside formation differs from the traditional prebiotic nucleotide syntheses and is also consistent with biological nucleotide synthesis. Phosphorylation occurred to the greatest extent in ribose compared to other aldopentoses, only in the presence of borate. Borate is known to improve the stability of ribose preferentially. Geological evidence suggests the presence of borate-rich settings on the early Earth. Therefore, borate-rich evaporitic environments could have facilitated preferential synthesis of ribonucleotide coupled with enhanced stability of ribose on the early Earth.
Depolarization imaging for fast and non-invasive monitoring of cervical microstructure remodeling in vivo during pregnancy
Authors: Rehbinder Jean , Vizet Jérémy , Park Junha , Ossikovski Razvigor , Vanel Jean-Charles , Nazac André , Pierangelo Angelo 
Published: July 2022

AbstractThe cervix plays a crucial role in conception, maintenance of pregnancy, and childbirth. The mechanical properties of a pregnant woman's cervix change dramatically during gestation due to a remodeling of its microstructure, necessary for delivery. However, external factors can accelerate this process and lead to prematurity, the primary cause of perinatal mortality worldwide, due to the inefficiency of existing diagnostic methods. This study shows that polarized light is a powerful tool to probe the cervical microstructure during pregnancy. A wide-field multispectral polarimetric imaging system was fabricated to explore in vivo the cervix of full-term pregnant women. The polarimetric properties of the cervix change significantly with pregnancy progression. In particular, a set of several depolarization parameters (intrinsic and extrinsic) showed a strong linear correlation with gestational age in the red part of the visible spectral range. This trend can be attributed, among other things, to a decrease in collagen density and an increase in hydration of cervical connective tissue. Wide field depolarization imaging is a very promising tool for rapid and non-invasive analysis of cervical tissue in vivo to monitor the steady progression of pregnancy, providing the practitioner with useful information to improve the detection of preterm birth.
Zoledronate combined metal-organic frameworks for bone-targeting and drugs deliveries
Authors: Pan Yixiao , Wang Jiahao , Jiang Zichao , Guo Qi , Zhang Zhen , Li Jingyi , Hu Yihe , Wang Long 
Published: July 2022

AbstractMedicine treatments for bone-related diseases such as osteoporosis, bone metastasis, osteomyelitis, and osteolysis are often limited by insufficient drug concentration at the lesion sites owing to the low perfusion of bone tissue. A carrier that can deliver multiple bone destruction site-targeting drugs is required to address this limitation. Here, we reported a novel bone-targeting nano-drug delivery platform formed by the integration of zoledronate (ZOL) and zeolitic imidazolate framework-8 (ZIF-8) nanoparticles. The ZOL mixed zeolitic imidazolate framework (ZZF) nanoparticles were synthesized in water at room temperature (25 °C), where many biomacromolecules could maintain their activity. This allowed the ZZF nanoparticles to adapt the encapsulation ability and pH response release property from ZIF-8 and the excellent bone targeting performance of ZOL simultaneously. Considering the ease of preparation and biomacromolecule-friendly drug delivery of this nano platform, it may be useful in treating bone-related diseases.
Bio-inspired contour extraction via EM-driven deformable and rotatable directivity-probing mask
Authors: Wang Jung-Hua , Huang Ren-Jie , Wang Ting-Yuan 
Published: July 2022

AbstractThis paper presents a novel bio-inspired edge-oriented approach to perceptual contour extraction. Our method does not rely on segmentation and can unsupervised learn to identify edge points that are readily grouped, without invoking any connecting mechanism, into object boundaries as perceived by human. This goal is achieved by using a dynamic mask to statistically assess the inter-edge relations and probe the principal direction that acts as an edge-grouping cue. The novelty of this work is that the mask, centered at a target pixel and driven by EM algorithm, can iteratively deform and rotate until it covers pixels that best fit the Bayesian likelihood of the binary class w.r.t a target pixel. By creating an effect of enlarging receptive field, contiguous edges of the same object can be identified while suppressing noise and textures, the resulting contour is in good agreement with gestalt laws of continuity, similarity and proximity. All theoretical derivations and parameters updates are conducted under the framework of EM-based Bayesian inference. Issues of stability and parameter uncertainty are addressed. Both qualitative and quantitative comparison with existing approaches proves the superiority of the proposed method in terms of tracking curved contours, noises/texture resilience, and detection of low-contrast contours.
Automatic parameter selection for electron ptychography via Bayesian optimization
Authors: Cao Michael C. , Chen Zhen , Jiang Yi , Han Yimo 
Published: July 2022

AbstractElectron ptychography provides new opportunities to resolve atomic structures with deep sub-angstrom spatial resolution and to study electron-beam sensitive materials with high dose efficiency. In practice, obtaining accurate ptychography images requires simultaneously optimizing multiple parameters that are often selected based on trial-and-error, resulting in low-throughput experiments and preventing wider adoption. Here, we develop an automatic parameter selection framework to circumvent this problem using Bayesian optimization with Gaussian processes. With minimal prior knowledge, the workflow efficiently produces ptychographic reconstructions that are superior to those processed by experienced experts. The method also facilitates better experimental designs by exploring optimized experimental parameters from simulated data.