bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraoperative High Fraction of Inspiratory Oxygen is Independently Associated with Worse Outcome After Living‐Donor Liver Transplantation: A Retrospective Study
Authors: Miyachi Yosuke , Kaido Toshimi , Hirata Masaaki , Sharshar Mohamed , Macshut Mahmoud , Yao Siyuan , Kamo Naoko , Kai Shinichi , Yagi Shintaro , Uemoto Shinji 
Published: April 2022

AbstractBackgroundIschemia and reperfusion injury is an important factor that determines graft function after liver transplantation, and oxygen plays a crucial role in this process. However, the relationship between the intraoperative high fraction of inspiratory oxygen (FiO2) and living‐donor‐liver‐transplantation (LDLT) outcome remains unclear.Patients and MethodsA total of 199 primary adult‐to‐adult LDLT cases in Kyoto University Hospital between January 2010 and December 2017 were enrolled in this study. The intraoperative FiO2 was averaged using the total amount of intraoperative oxygen and air and defined as the calculated FiO2 (cFiO2). The cutoff value of cFiO2 was set at 0.5.ResultsBetween the cFiO2 <0.5 (n = 156) and ≥0.5 group (n = 43), preoperative recipients’ background, donor factors, and intraoperative parameters were almost comparable. Postoperatively, the cFiO2 ≥0.5 group showed a higher early allograft dysfunction (EAD) rate (P = 0.049) and worse overall graft survival (P = 0.036) than the cFiO2 <0.5 group. Although the cFiO2 ≥0.5 was not an independent risk factor for EAD in multivariable analysis (OR 2.038, 95%CI 0.992–4.186, P = 0.053), it was an independent risk factor for overall graft survival after LDLT (HR 1.897, 95%CI 1.007–3.432, P = 0.048).ConclusionThe results of this study suggest that intraoperative high FiO2 may be associated with worse graft survival after LDLT. Avoiding higher intraoperative FiO2 may be beneficial for LDLT recipients.
Neurophysiological and behavioural correlates of ocrelizumab therapy on manual dexterity in patients with primary progressive multiple sclerosis
Authors: Dubbioso Raffaele , Bove Marco , Boccia Daniele , D’Ambrosio Vincenzo , Nolano Maria , Manganelli Fiore , Iodice Rosa 
Published: April 2022

Abstract
Background
Hand dexterity impairment is a key feature of disability in people with primary progressive multiple sclerosis (PPMS). So far, ocrelizumab, a recombinant humanized monoclonal antibody that selectively depletes CD20-expressing B cells, is the only therapy approved for PPMS and recent analysis reported its ability to reduce the risk of upper limb disability progression. However, the neural mechanisms underlying hand impairment in PPMS and the brain networks behind the effect of ocrelizumab on manual dexterity are not fully understood.

Objective
Main aims of our study were: (i) to investigate neurophysiological and behavioural correlates of hand function impairment in subjects with PPMS, and (ii) to use neurophysiologic and behavioural measures to track the effects of ocrelizumab therapy on manual dexterity.

Methods
Seventeen PPMS patients and 17 healthy-controls underwent routine neurophysiological protocols assessing the integrity of cortico-spinal and somatosensory pathways and advanced transcranial magnetic stimulation (TMS) protocols evaluating inhibitory (short and long interval intracortical inhibition, short-latency afferent inhibition) and facilitatory (motor thresholds, intracortical facilitation, short-interval intracortical facilitation) circuits in the primary motor cortex. All subjects also underwent behavioural analysis of hand dexterity by means of nine-hole peg test and finger movement analysis, and hand strength with handgrip and three-point pinch test. Neurophysiological and clinical assessments of hand functionality were also performed after 1 year of ocrelizumab therapy.

Results
At baseline PPMS patients displayed a significant impairment of hand dexterity and strength compared to healthy controls (all p < 0.03). Neurophysiological study disclosed prolonged latencies of standard somatosensory and motor evoked potentials (all p < 0.025) and an overall reduction of intracortical excitability at TMS protocols, involving both excitatory and inhibitory circuits. Importantly, hand dexterity impairment, indexed by delayed 9HPT, correlated with TMS protocols investigating cortical sensorimotor integration (short-latency afferent inhibition, SAI), p = 0.009. Both parameters, 9HPT (p = 0.01) and SAI (p = 0.01), displayed a significant improvement after 1 year of therapy with ocrelizumab.

Conclusion
Intracortical sensorimotor networks are involved in hand dexterity dysfunction of PPMS. Ocrelizumab therapy displays a beneficial effect on hand dexterity impairment most likely through intracortical networks implicated in fast sensorimotor integration.
Symptoms associated with a COVID-19 infection among a non-hospitalized cohort in Vienna
Authors: Munsch Nicolas , Gruarin Stefanie , Nateqi Jama , Lutz Thomas , Binder Michael , Aberle Judith H. , Martin Alistair , Knapp Bernhard 
Published: April 2022

SummaryBackgroundMost clinical studies report the symptoms experienced by those infected with coronavirus disease 2019 (COVID-19) via patients already hospitalized. Here we analyzed the symptoms experienced outside of a hospital setting.MethodsThe Vienna Social Fund (FSW; Vienna, Austria), the Public Health Services of the City of Vienna (MA15) and the private company Symptoma collaborated to implement Vienna’s official online COVID-19 symptom checker. Users answered 12 yes/no questions about symptoms to assess their risk for COVID-19. They could also specify their age and sex, and whether they had contact with someone who tested positive for COVID-19. Depending on the assessed risk of COVID-19 positivity, a SARS-CoV‑2 nucleic acid amplification test (NAAT) was performed. In this publication, we analyzed which factors (symptoms, sex or age) are associated with COVID-19 positivity. We also trained a classifier to correctly predict COVID-19 positivity from the collected data.ResultsBetween 2 November 2020 and 18 November 2021, 9133 people experiencing COVID-19-like symptoms were assessed as high risk by the chatbot and were subsequently tested by a NAAT. Symptoms significantly associated with a positive COVID-19 test were malaise, fatigue, headache, cough, fever, dysgeusia and hyposmia. Our classifier could successfully predict COVID-19 positivity with an area under the curve (AUC) of 0.74.ConclusionThis study provides reliable COVID-19 symptom statistics based on the general population verified by NAATs.
Body mass index at diagnosis of a childhood brain tumor; a reflection of hypothalamic-pituitary dysfunction or lifestyle?
Authors: van Roessel I. M. A. A. , van Schaik J. , Meeteren A. Y. N. Schouten-van , Boot A. M. , der Grinten H. L. Claahsen-van , Clement S. C. , van Iersel L. , Han K. S. , van Trotsenburg A. S. P. , Vandertop W. P. , Kremer L. C. M. , van Santen H. M. 
Published: April 2022

Abstract
Purpose
Childhood brain tumor survivors (CBTS) are at risk of becoming overweight, which has been shown to be associated with hypothalamic-pituitary (HP) dysfunction during follow-up. Body mass index (BMI) at diagnosis is related to BMI at follow-up. It is uncertain, however, whether aberrant BMI at brain tumor diagnosis reflects early hypothalamic dysfunction or rather reflects genetic and sociodemographic characteristics. We aimed to examine whether BMI at childhood brain tumor diagnosis is associated with HP dysfunction at diagnosis or its development during follow-up.

Methods
The association of BMI at diagnosis of a childhood brain tumor to HP dysfunction at diagnosis or during follow-up was examined in a Dutch cohort of 685 CBTS, excluding children with craniopharyngioma or a pituitary tumor. Individual patient data were retrospectively extracted from patient charts.

Results
Of 685 CTBS, 4.7% were underweight, 14.2% were overweight, and 3.8% were obese at diagnosis. Being overweight or obese at diagnosis was not associated with anterior pituitary deficiency or diabetes insipidus at diagnosis or during follow-up. In children with suprasellar tumors, being obese at diagnosis was associated with central precocious puberty.

Conclusion
Overweight or obesity at diagnosis of a childhood brain tumor seems not to be associated with pituitary deficiencies. These results suggest that genetics and lifestyle may be more important etiologic factors for higher BMI at diagnosis in these children than hypothalamic dysfunction. To improve the long-term outcome of CBTS with regards to overweight and obesity, more attention should be given to lifestyle already at the time of brain tumor treatment.
Effectiveness of adding alarms to flash glucose monitoring in adults with type 1 diabetes under routine care
Authors: Boscari Federico , Ferretto Sara , Cavallin Francesco , Fadini Gian Paolo , Avogaro Angelo , Bruttomesso Daniela 
Published: April 2022

Abstract
Aim
Whether glucose sensor alarms improve metabolic control and are accepted by individuals with diabetes is unclear. Here, we investigated whether switching from a standard flash glucose monitoring system (FGM1) to a system equipped with hypo- and hyperglycemia alarms (FGM2) improves glycemic control and psychological outcomes in adults with type 1 diabetes (T1D).

Methods
Subjects with T1D and > 4% of time in hypoglycemia or > 40% of time in hyperglycemia were studied while wearing FGM1 (4 weeks) and after switching to FGM2 for 8 weeks. The primary endpoint was the change in time in range (TIR 70–180 mg/dl [3.9–10.0 mmol/L]) after 4 weeks of FGM2 use. Time below range (TBR), time above range (TAR), mean glucose, coefficient of variation (CV), sensor scans, treatment satisfaction, and hypoglycemia fear were secondary outcomes.

Results
We included 38 subjects aged 33.7 ± 12.6 year. During 4 weeks of FGM2 use, TIR increased from 52.8 to 57.0% (p = 0.001), TBR decreased from 6.2 to 3.4% (p < 0.0001) as did time < 54 mg/dl (from 1.4 to 0.3%, p < 0.0001) and CV (from 39.6% to 36.1%, p < 0.0001). These changes were confirmed after 8 weeks of FGM2 use. Treatment satisfaction improved and fear of hypoglycemia decreased.
Subjects who had > 4% of time in hypoglycemia at baseline showed the greatest improvements in glucose control and treatment satisfaction.

Conclusion
Switching from FGM1 to FGM2 improved TIR and treatment satisfaction and reduced fear of hypoglycemia. Participants who benefited most from switching from FGM1 to FGM2 were those prone to hypoglycemia.
Insomnia evaluation and treatment during peripartum: a joint position paper from the European Insomnia Network task force “Sleep and Women,” the Italian Marcè Society and international experts task force for perinatal mental health
Authors: Palagini Laura , Bramante Alessandra , Baglioni Chiara , Tang Nicole , Grassi Luigi , Altena Ellemarije , Johann Anna F. , Geoffroy Pierre Alexis , Biggio Giovanni , Mencacci Claudio , Sharma Verinder , Riemann Dieter 
Published: April 2022

AbstractInsomnia symptoms are frequent during peripartum and are considered risk factors for peripartum psychopathology. Assessing and treating insomnia and related conditions of sleep loss during peripartum should be a priority in the clinical practice. The aim of this paper was to conduct a systematic review on insomnia evaluation and treatment during peripartum which may be useful for clinicians. The literature review was carried out between January 2000 and May 2021 on the evaluation and treatment of insomnia during the peripartum period. The PubMed, PsycINFO, and Embase electronic databases were searched for literature published according to the PRISMA guidance with several combinations of search terms “insomnia” and “perinatal period” or “pregnancy” or “post partum” or “lactation” or “breastfeeding” and “evaluation” and “treatment.” Based on this search, 136 articles about insomnia evaluation and 335 articles on insomnia treatment were found and we conducted at the end a narrative review. According to the inclusion/exclusion criteria, 41 articles were selected for the evaluation part and 22 on the treatment part, including the most recent meta-analyses and systematic reviews. Evaluation of insomnia during peripartum, as for insomnia patients, may be conducted at least throughout a clinical interview, but specific rating scales are available and may be useful for assessment. Cognitive behavioral therapy for insomnia (CBT-I), as for insomnia patients, should be the preferred treatment choice during peripartum, and it may be useful to also improve mood, anxiety symptoms, and fatigue. Pharmacological treatment may be considered when women who present with severe forms of insomnia symptoms do not respond to nonpharmacologic therapy.
An approach for performance requirements verification and test environments generation
Authors: Abdeen Waleed , Chen Xingru , Unterkalmsteiner Michael 
Published: April 2022

AbstractModel-based testing (MBT) is a method that supports the design and execution of test cases by models that specify the intended behaviors of a system under test. While systematic literature reviews on MBT in general exist, the state of the art on modeling and testing performance requirements has seen much less attention. Therefore, we conducted a systematic mapping study on model-based performance testing. Then, we studied natural language software requirements specifications in order to understand which and how performance requirements are typically specified. Since none of the identified MBT techniques supported a major benefit of modeling, namely identifying faults in requirements specifications, we developed the Performance Requirements verificatiOn and Test EnvironmentS generaTion approach (PRO-TEST). Finally, we evaluated PRO-TEST on 149 requirements specifications. We found and analyzed 57 primary studies from the systematic mapping study and extracted 50 performance requirements models. However, those models don’t achieve the goals of MBT, which are validating requirements, ensuring their testability, and generating the minimum required test cases. We analyzed 77 Software Requirements Specification (SRS) documents, extracted 149 performance requirements from those SRS, and illustrate that with PRO-TEST we can model performance requirements, find issues in those requirements and detect missing ones. We detected three not-quantifiable requirements, 43 not-quantified requirements, and 180 underspecified parameters in the 149 modeled performance requirements. Furthermore, we generated 96 test environments from those models. By modeling performance requirements with PRO-TEST, we can identify issues in the requirements related to their ambiguity, measurability, and completeness. Additionally, it allows to generate parameters for test environments.
Locomotion and flow speed preferences in natural habitats by large water striders, Ptilomera tigrina, with micro-morphological adaptations for rowing
Authors: Kim Woojoo , Pham Thai Hong , Nguyen Phuong Dung , Tran Anh Duc , Ha Jungmoon , Jablonski Piotr G. , Lee Sang-im 
Published: April 2022

AbstractWater strider (Gerridae) morphology and behavior have become the focus of interdisciplinary research in biological diversification and bio-inspired technology. However, the diversity of behaviors and morphology of the large-sized Gerridae have not been intensely studied. Here, we provide locomotory behaviors and legs’ micro-morphology of the large South-East Asian water strider,Ptilomera tigrina. Using high-speed videography and experiments in natural habitats, as well as scanning electron microscopy of midlegs, we have determined that (1)P. tigrinaindividuals prefer relatively high flow speeds of 0.15–0.30 m/s, compared to other water striders previously studied, and they are also observed in very high flow speeds of up to 0.6 m/s; (2) they avoid stagnant water, but when on still and very slow flowing water they perform constant back-and-forth rowing using their midlegs; (3) their antipredatory reaction involves repetitive and very fast “protean” movements propelled by the midlegs; (4) their midleg tarsi and tibiae are equipped with brushes of ribbon-like hairs, which are used as paddles for rowing. As the locomotory behaviors and flow-speed preferences byP. tigrinarequire constant use of midlegs for rowing, the presence of special paddle structures on midlegs illustrates a hypothetical adaptive match between midlegs’ locomotory function and their micro-morphology.
Determination of oxygen relaxivity in oxygen nanobubbles at 3 and 7 Tesla
Authors: Bluemke Emma , Young Liam A. J. , Owen Joshua , Smart Sean , Kinchesh Paul , Bulte Daniel P. , Stride Eleanor 
Published: April 2022

Abstract
Objective
Oxygen-loaded nanobubbles have shown potential for reducing tumour hypoxia and improving treatment outcomes, however, it remains difficult to noninvasively measure the changes in partial pressure of oxygen (PO2) in vivo. The linear relationship between PO2 and longitudinal relaxation rate (R1) has been used to noninvasively infer PO2 in vitreous and cerebrospinal fluid, and therefore, this experiment aimed to investigate whether R1 is a suitable measurement to study oxygen delivery from such oxygen carriers.

Methods
T1 mapping was used to measure R1 in phantoms containing nanobubbles with varied PO2 to measure the relaxivity of oxygen (r1Ox) in the phantoms at 7 and 3 T. These measurements were used to estimate the limit of detection (LOD) in two experimental settings: preclinical 7 T and clinical 3 T MRI.

Results
The r1Ox in the nanobubble solution was 0.00057 and 0.000235 s−1/mmHg, corresponding to a LOD of 111 and 103 mmHg with 95% confidence at 7 and 3 T, respectively.

Conclusion
This suggests that T1 mapping could provide a noninvasive method of measuring a > 100 mmHg oxygen delivery from therapeutic nanobubbles.
The Protective Performance of Modern Motorcycle Helmets Under Oblique Impacts
Authors: Yu Xiancheng , Logan Ingrid , de Pedro Sarasola Itziar , Dasaratha Atulit , Ghajari Mazdak 
Published: April 2022

AbstractMotorcyclists are at high risk of head injuries, including skull fractures, focal brain injuries, intracranial bleeding and diffuse brain injuries. New helmet technologies have been developed to mitigate head injuries in motorcycle collisions, but there is limited information on their performance under commonly occurring oblique impacts. We used an oblique impact method to assess the performance of seven modern motorcycle helmets at five impact locations. Four helmets were fitted with rotational management technologies: a low friction layer (MIPS), three-layer liner system (Flex) and dampers-connected liner system (ODS). Helmets were dropped onto a 45° anvil at 8 m/s at five locations. We determined peak translational and rotational accelerations (PTA and PRA), peak rotational velocity (PRV) and brain injury criteria (BrIC). In addition, we used a human head finite element model to predict strain distribution across the brain and in corpus callosum and sulci. We found that the impact location affected the injury metrics and brain strain, but this effect was not consistent. The rear impact produced lowest PTAs but highest PRAs. This impact produced highest strain in corpus callosum. The front impact produced the highest PRV and BrIC. The side impact produced the lowest PRV, BrIC and strain across the brain, sulci and corpus callosum. Among helmet technologies, MIPS reduced all injury metrics and brain strain compared with conventional helmets. Flex however was effective in reducing PRA only and ODS was not effective in reducing any injury metrics in comparison with conventional helmets. This study shows the importance of using different impact locations and injury metrics when assessing head protection effects of helmets. It also provides new data on the performance of modern motorcycle helmets. These results can help with improving helmet design and standard and rating test methods.
“Engaging the Enemy”: Orangutan (Pongo pygmaeus morio) Conservation in Human Modified Environments in the Kinabatangan floodplain of Sabah, Malaysian Borneo
Authors: Oram Felicity , Kapar Mohamed Daisah , Saharon Abdul Rajak , Elahan Hamisah , Segaran Pravind , Poloi Shernytta , Saidal Haslan , Abulani Ahbam , Lackman Isabelle , Ancrenaz Marc 
Published: April 2022

Abstract

Throughout the equatorial tropics, forest conversion to agriculture often fragments crucial primate habitat. In 30 years, 80% of the alluvial lowland forests along the Kinabatangan River in Sabah, Malaysian Borneo, have been supplanted by oil palm (Elaeis guineensis) plantations. Today, only about 20% of the former orangutan (Pongo pygmaeus morio) population remains in the region. Because most of the land is now under the tenure of agribusiness companies, we used a pragmatic approach of mixed biosocial methods and citizen science engagement of oil palm growers (N = 6) as active conservation partners to study orangutan use of the privately administered landscape between protected forest fragments. We found that 22 of 25 remanent forest patches (0.5 to 242 hectares) surveyed within plantations contained food or shelter resources useful for orangutans. Of these, 20 are in regular transitory use by wider-ranging adult male orangutans, and in 9 patches, females are resident and raising offspring isolated within oil palm plantations. These findings indicate that orangutans retain a measure of normal metapopulation dynamics necessary for viability at the landscape level despite drastic habitat modification. We found that barriers to in situ conservation in these agroforest matrices were due to the following misconceptions across sectors: 1) Good farming practices require exclusion of wildlife; 2) Orangutans seen in plantations must be “rescued” by people; and 3) Translocation is an appropriate conservation strategy, and nondetrimental to orangutans. Our exploratory study exemplifies the value of biosocial methods and collaboration with industrial-scale farmers to support primate resilience in forests fragmented by agriculture.
The Clinical Frailty Scale as useful tool in patients with brain metastases
Authors: Kerschbaumer Johannes , Krigers Aleksandrs , Demetz Matthias , Pinggera Daniel , Klingenschmid Julia , Pichler Nadine , Thomé Claudius , Freyschlag Christian F. 
Published: April 2022

Abstract
Purpose
The Clinical Frailty Scale (CFS) evaluates patients’ level of frailty on a scale from 1 to 9 and is commonly used in geriatric medicine, intensive care and orthopedics. The aim of our study was to reveal whether the CFS allows a reliable prediction of overall survival (OS) in patients after surgical treatment of brain metastases (BM) compared to the Karnofsky Performance Score (KPS).

Methods
Patients operated for BM were included. CFS and KPS were retrospectively assessed pre- and postoperatively and at follow-up 3–6 months after resection.

Results
205 patients with a follow-up of 22.8 months (95% CI 18.4–27.1) were evaluated. CFS showed a median of 3 (“managing well”; IqR 2–4) at all 3 assessment-points. Median KPS was 80 preoperatively (IqR 80–90) and 90 postoperatively (IqR 80–100) as well as at follow-up after 3–6 months. CFS correlated with KPS both preoperatively (r = − 0.92; p < 0.001), postoperatively (r = − 0.85; p < 0.001) and at follow-up (r = − 0.93; p < 0.001).
The CFS predicted the expected reduction of OS more reliably than the KPS at all 3 assessments. A one-point increase (worsening) of the preoperative CFS translated into a 30% additional hazard to decease (HR 1.30, 95% CI 1.15–1.46; p < 0.001). A one-point increase in postoperative and at follow-up CFS represents a 39% (HR 1.39, 95% CI 1.25–1.54; p < 0.001) and of 42% risk (HR 1.42, 95% CI 1.27–1.59; p < 0.001).

Conclusion
The CFS is a feasible, simple and reliable scoring system in patients undergoing resection of brain metastasis. The CFS 3–6 months after surgery specifies the expected OS more accurately than the KPS.