bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemberdayaan Masyarakat Pada Akses Sanitasi Berkelanjutan
Authors: Mas’adah Najah Alvi 
Published: October 2022

Abstract

This study aims to describe community empowerment for access to sustainable sanitation, a case study in Doudo Village, Panceng District, Gresik Regency, East Java. The method used in this research is descriptive qualitative research method. The selection of informants was done by purposive sampling. Data obtained through interviews, observation and documentation. The data analysis technique used qualitative analysis. The results of the research on the implementation of empowerment were carried out in three stages, namely: (a) the awareness stage by conducting socialization to the community which was considered optimal supported by high community participation to participate in the socialization, (b) the capacity stage involving program participants into activities including training activities, pre-construction activities, and health counseling activities that are considered good are supported by the delivery of detailed and clear material, and (c) the empowerment stage with the ability of program participants to help Doudo Village realize sanitation goals.

Keywords: community empowerment, sustainable sanitation.

Abstrak

Penelitian ini bertujuan mendiskripsikan pemberdayaan masyarakat untuk akses sanitasi berkelanjutan studi kasus di Desa Doudo, Kecamatan Panceng, Kabupaten Gresik, Jawa Timur. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif deskriptif. Pemilihan informan dilakukan dengan purposive sampling. Data didapatkan melalui wawancara, observasi dan dokumentasi. Teknik analisis data menggunakan analisis kualitatif. Hasil penelitian pelaksanaanpemberdayaan dilakukan melalui tiga tahap yaitu: (a) tahap penyadaran dengan melakukan sosialisasi kepada masyarakat yang dinilai optimal didukung dengan partisipasi masyarakat yang tinggi untuk mengikuti sosialisasi, (b) tahap pengkapasitasan melibatkan peserta program kedalam kegiatan meliputi kegiatan pelatihan, kegiatan pra konstruksi, dan kegiatan penyuluhan kesehatan yang dinilai baik didukung dengan penyampaian materi secara rinci dan jelas, dan (c) tahap pendayaan dengan adanya kemampuan peserta program membantu Desa Doudo mewujudkan tujuan sanitasi.

Kata kunci: pemberdayaan masyarakat, sanitasi berkelanjutan.
Dimorfismo sexual del agujero magno en tomografías de una población peruana
Authors: Victoria Parra Diana J , Súarez Ponce Daniel Guillermo , Velezmoro Montes Ymelda Wendy , Vigo Garcia Carlos 
Published: October 2022

Introducción: La base del cráneo es una estructura compacta, muy resistente a los daños físicos, la robustez del hueso occipital y la posición anatómica protegida del agujero magno bajo una profundidad de tejido blando pueden hacerlo menos vulnerable a la fragmentación y a los efectos de los procesos tafonómicos en comparación con otras estructuras óseas, lo que permite utilizarlo para estimar el dimorfismo sexual. Objetivo: Establecer la relación entre el dimorfismo sexual y la morfometría del agujero magno en tomografías de pacientes mayores o iguales a los 18 años que asistieron a consultorios privados en Lima metropolitana, durante los años 2015 al 2020. Materiales y métodos: El estudio se desarrolló con 239 tomografías (88 masculinos y 151 femeninos). Se realizaron mediciones del agujero magno de los diámetros anteroposterior máximo (DAPM), transversal máximo (DTM) y el área se estableció mediante la fórmula de Teixeira. Resultados: El DAPM presentó una media en el sexo masculino de 37,182+ 2,4012 mm y en el femenino de 34,795+ 2,1086 mm, mientras que para el DTM se estableció una media en el sexo masculino de 32,517+ 2,3463 mm y para el femenino de 30,514+ 2,2084 mm, en el área según Teixeira (A TEIXEIRA) en el sexo masculino se observó una media de 957,21390 +115,162403mm2 y en el femenino de 840,11055 + 93,775088mm2. Se establece una relación estadística (p<0.05) entre los parámetros DAPM, DTM, A TEIXEIRA entre ambos sexos. Conclusión: Existe relación entre el dimorfismo sexual y la morfometría del agujero magno, con una predicción 71.96 %.
Análisis de máxima tensión compresiva en incisivos centrales superiores rehabilitados con postes de fibra de vidrio y tres tipos de coronas. Un estudio con método de elementos finitos.
Authors: Chávez Vela Mayra J. , López Flores Ana I. 
Published: October 2022

Objetivo: Evaluar la máxima tensión compresiva en incisivos centrales superiores restaurados con postes de fibra de vidrio y tres tipos de coronas por método de elementos finitos MEF. Materiales y métodos: El estudio fue un ensayo de laboratorio virtual y descriptivo. Se confeccionaron 3 modelos virtuales mediante el programa SolidWorks 2017, a partir de incisivos centrales superiores rehabilitados con postes de fibra de vidrio y corona metal-cerámica, corona de disilicato de litio monolítica y corona de zirconio-cerámica; luego, estos fueron sometidos a una carga oclusal oblicua de 150 N con una angulación de 45°, distribuida hacia la cara palatina. El análisis de las tensiones se realizó mediante la comparación de las tensiones máximas, mínimas y equivalentes de Von Mises. Resultados: La máxima tensión compresiva se encontró a nivel cervical en la zona vestibular de cada una de las coronas, siendo el diseño 3 (corona de zirconio-cerámica) el que presentó mayor tensión compresiva, con 73,89 MPa, seguido por el diseño 2 (corona de disilicato de litio), con 63,42 MPa, y el diseño 1 (corona metal-cerámica), con 48,4 MPa. Conclusión: La corona zirconio-cerámica distribuye mejor la tensión a lo largo del diente, ya que, por su rigidez, absorbe las tensiones que se concentran especialmente en cervical, lo que podría indicar que es la opción más apropiada para rehabilitar dientes tratados endodónticamente.
A Hybrid SEIHCRDV-UKF Model for COVID-19 Prediction. Application on real-time data
Authors: Papageorgiou Vasileios E. , Tsaklidis George 
Published: October 2022

Abstract
The prevalence of COVID-19 has been the most serious health challenge of the 21th century to date, concerning national health systems on a daily basis, since December 2019 when it appeared in Wuhan City. Prediction of pandemic spread plays an important role in effectively reducing this highly contagious disease. Nevertheless, most of the proposed mathematical methodologies, which aim to describe the dynamics of the pandemic, rely on deterministic models that are not able to reflect the true nature of the spread of COVID. In this paper, we propose a SEIHCRDV model – an extension of the classic SIR compartmental model – which also takes into consideration the populations of exposed, hospitalized, admitted in intensive care units (ICU), deceased and vaccinated cases, in combination with an unscented Kalman filter (UKF), providing a dynamic estimation of the time dependent parameters of the system. Apparently, this new consideration could be useful for examining also other pandemics. We examine the reliability of our model over a long period of 265 days, where we observe two major waves of infection, starting in January 2021 which signified the start of vaccinations in Europe, providing quite encouraging predictive performance. Finally, special emphasis is given to proving the non-negativity of SEIHCRDV model, to achieve a representative basic reproductive number R0 and to investigating the existence and stability of disease equilibriums in accordance with the formula produced to estimate R0.
Clinical Factors Associated with Maternal Death in Pregnant Women Infected by COVID-19 in Indonesia: A Multicenter Prospective Study
Authors: Akbar Muhammad Ilham Aldika , Irwinda Rima , Dewantiningrum Julian , Bernolian Nuswil , Sitepu Makmur , Chalid Maisuri Tadjuddin , Noryanto Mukhamad , Yeni Cut Meurah , Wantania John , Budayasa Anak Agung Gede Raka , Aziz Muhammad Alamsyah 
Published: October 2022

AbstractPurpose: The aim of this study is to evaluate the clinical risk factors associated with maternal death in pregnant women infected by COVID-19. Material and methods: This is a multicenter prospective study in Indonesia, included all pregnant women with confirmed COVID-19. Participants was divided into two groups based on the final outcomes: maternal death group and survived group. The main outcomes evaluated were: maternal background, clinical risk factors, comorbidities, clinical characteristics, and laboratory results. Results: There were 89 participants in the maternal death group and 1673 in survived group. The maternal death group have an older maternal ages (32 vs 31 years old,p=0.03) and earlier gestational ages during admission (33 vs 37 weeks,p=0.000). The maternal death group have a significantly higher rate of cardiac disease (6.5% vs 1.2%, p=0.004), acute kidney injury (5.2% vs 0.3%, p=0.000), coinfections (29.9% vs 10.8%, p=0.000), and anemia (14.3% vs 6.7%,p=0.012). The maternal death group have a higher level of maternal blood leukocyte (13970 vs 10345), netrofil 75.7 vs 70), ALT (47 vs 23), AST (26 vs 19), CRP (37.4 vs 0.7), and procalcitonin (0.27 vs 0.06) (p<0.05). The risk factors that independently related to maternal death are fever (Exp(B): 12.847, 95% CI: 5.638-29.277;p=0.000), pneumonia from chest x-ray (Exp(B): 2.524, 95% CI: 1.163-5.479;p=0.019), and ICU admission (Exp(B): 49.430, 95% CI: 21.024-116.215;p=0.000).Conclussion: Our research indicates that the presence of fever, pneumonia, and ICU hospitalization are independently associated with maternal mortality in COVID-19-infected pregnant women.
Optimization of Centrifugal Compressor Splitter Blades Design Based on Regression Kriging Algorithm
Authors: Wang Zhongyi , Wang Ruihao , Wang Yanhua , Wang Meng , Li Zheng 
Published: October 2022

Abstract
Centrifugal compressors are widely used in ships, automobiles, aerospace and other fields. At present, the centrifugal compressor is usually designed with splitter blades to achieve a high pressure ratio and avoid airflow blockage at the leading edge throat of the main blade. This paper offers a multivariable optimization method for splitter blades design of centrifugal compressor. The length and circumferential position of the splitter blades are coupled to optimize the isentropic efficiency by using the Latin hypercube sampling, Regression Kriging algorithm and genetic algorithm. After optimization, the results show that the length of the splitter blades is shorter and its position is inclined to the pressure surface of the main blades. The maximum isentropic efficiency increased by 0.62%, the flow rate of the impeller surge point increased by 1.78%, and the flow rate of the plug point increased by 1.74%. After optimization, the low-speed zone of the flow field in the impeller decreases and the internal passages become more smooth. Besides, the degree of airflow obstruction is reduced, and the overall efficiency of the impeller is improved. The multivariable optimization method which is based on the Regression Kriging algorithm has certain universality and can provide important reference for the splitter blades design of centrifugal compressors and other turbomachinery.
RBCK1 regulates the progression of ER-positive breast cancer through the HIF1α signaling
Authors: Niu Zhiguo , Fan Jianing , Chen Fengzhe , Yang Huijie , Li Xin , Zhuang Ting , Guo Chunlei , Cao Qi , Zhu Jian , Wang Hui , Huang Qingsong 
Published: October 2022

Abstract
Breast cancer is the most malignant malignancy in women on a global scale. It can generally be divided into four main categories, of which estrogen receptor ER-positive breast cancer accounts for most breast cancer cases. RBCK1 protein is an E3 ubiquitin ligase containing the UBL, NZF, and RBR domains. It is well known to exhibit abnormal expression in breast tumors, making it a valuable diagnostic marker and drug target. Additionally, studies have confirmed that in breast cancer, about 25 to 40% of tumors appear as visible hypoxic regions, while in hypoxia, tumor cells can activate the hypoxia-inducing factor HIF-1 pathway and widely activate the expression of downstream genes. Previous studies have confirmed that HIF-1α is highly important in tumor recurrence and metastasis. This research aims to identify RBCK1 as an important regulator of HIF1α signaling pathway. Targeted therapy with RBCK1 could be a promising treatment strategy for ER-positive breast cancer.
Change Detection in a Rural Landscape: A case study of processes and main driving factors along with its response to thermal environment in Farim, Iran
Authors: Estalkhsari Bonin Mahdavi , Mohammad Pir , Razavi Niloofar 
Published: October 2022

Abstract
This study aims to investigate the alteration of land use land cover (LULC) change and its response to change in land surface temperature (LST) and heat island phenomena of a rural district of Farim in the north of Iran from 1990 to 2020 using multi-date Landsat data. The LULC result suggests that most land cover type changes are dedicated to bare land with a 24.83 km2 gain (+80.87%). The result demonstrates that the main changing factors of the bare land are population/precipitation and temperature/population. Additionally, the effect of LULC change on seasonal LST and urban heat island (UHI) is also analyzed in this study. The result witnessed a significant rise of LST in both the summer and winter seasons of about 12.87 °C and 14.2 °C, respectively. The urban thermal field variance index (UTFVI) shows the strongest zone in the central area and no UTFVI zone in the surrounding region.
Unsupervised Restoration of a Complex Learned Behavior After Large-Scale Neuronal Perturbation
Authors: Lois Carlos , Wang Bo , Torok Zsofia , duffy alison , bell david , wongso shelyn , velho tarciso , Fairhall Adrienne 
Published: October 2022

Abstract

Reliable execution of behaviors requires that brain circuits correct for variations in neuronal dynamics. Genetic perturbation of the majority of excitatory neurons in a brain region involved in song production in adult songbirds with stereotypical songs triggered severe degradation of their songs. The song fully recovered within two weeks, and substantial improvement occurred even when animals were prevented from singing during the recovery period, indicating that offline mechanisms enable recovery in an unsupervised manner. Song restoration was accompanied by increased excitatory synaptic inputs to unmanipulated neurons in the same region. A model inspired by the behavioral and electrophysiological findings suggests that a combination of unsupervised single-cell and population-level homeostatic plasticity rules can support the observed functional restoration after large-scale disruption of networks implementing sequential dynamics. In the model the sequence is restored through a parallel homeostatic process, rather than regrown serially, and predicts that sequences should recover in a saltatory fashion. Correspondingly, we observed such recovery in the songs of manipulated animals, with syllables that rapidly alternate between abnormal and normal durations from rendition to rendition until eventually they permanently settled into their original length. These observations indicate the existence of cellular and systems-level restorative mechanisms that ensure behavioral resilience.
Optimization of the Culture of Chlorella Sorokiniana PA.91 by RSM: Effect of temperature, light intensity, and MgAC-NPs
Authors: Bisheh masoumeh panbehkar , Amini-rad hasan 
Published: October 2022

Abstract
The condition of the cultivation of newly isolated strains, Chlorella Sorokiniana PA.91, was optimized for the first time for magnesium Amino clay nanoparticles (MgAC-NPs) at various temperatures and light intensities in the culture medium of municipal wastewater (MWW) by Central Composite Design in the Response Surface Methodology (RSM-CCD). This study studied MgAC-NPs synthesized with their characteristics FE-SEM, EDX, XRD, and FT-IR. The synthesized MgAC-NPs were naturally stable, cubic-shaped, within the size range of 30–60 nm. The optimization results show that at culture conditions of 20°C, 37 µmol m− 2s− 1 and 0.05 g L− 1 microalga MgAC-NPs have the best growth productivity and biomass performance. Maximum dry biomass weight (55.41%), specific growth rate (30.26%), chlorophyll (81.26%), and carotenoids (35.71%) were achieved under the optimized condition. Experimental results displayed that C. S PA.91 has a high capacity for lipid extraction (1.36 g L− 1) and significant lipid efficiency (45.1%). Also, in 0.2 g L− 1 of the MgAC- NPs, COD removal efficiency (91.1%) from C.S PA.91 -MgAC-NPs showed. These results showed the potential of C.S PA.91 -MgAC-NPs for nutrient removal in wastewater treatment plants and their quality as sources of biodiesel.
Ionized carbon tracing the assembly of interstellar clouds
Authors: Schneider Nicola , Bonne Lars , Bontemps Sylvain , Kabanovic Slawa , Simon Robert , Ossenkopf-Okada Volker , Buchbender Christof , Stutzki Jürgen , Mertens Marc , Ricken Oliver , Csengeri Timea , Tielens Alexander 
Published: October 2022

Abstract
Molecular hydrogen clouds are a key component of the interstellar medium because they are the birthplaces for stars.
However, the details of how molecular clouds assemble and interact are still largely unknown. Thanks to new observations of the 158 micron line of ionized carbon [CII] in the Cygnus region within the FEEDBACK program on SOFIA, we present for the first time compelling evidence that [CII] unveils dynamic interactions between cloud ensembles. This process is neither a head-on collision of fully molecular clouds nor a gentle merging of only atomic clouds. Moreover, we demonstrate that the dense molecular clouds associated with the DR21 and W75N star-forming regions and a cloud at higher velocity are embedded in atomic gas and all components interact over a large range of velocities (~20 km/s). The atomic gas has a density of ~100 cm-3 and a
temperature of ~100 K. We promote that this type of interaction, solely traced in [CII], is the most common process of molecular cloud formation and anticipate further detections of this phenomenon in other regions.
Trametinib activates endogenous neurogenesis and recovers neuropathology in a model of Alzheimer’s disease
Authors: Yoon Ki-Jun , Kim Mi-Yeon , Kim Mi Jeong , Lee Changyeob , Kim Hyoung Tae , Seo Jinsoo , Han Sungho 
Published: October 2022

Abstract
Enhancing adult neurogenesis in the brain has been suggested as a potential therapeutic for AD. We developed a screening platform ATRIVIEW® for molecules activating neuronal differentiation of adult mouse NSCs. Among FDA-approved drugs, the most potent hit was SNR1611 (trametinib), a selective MEK1/2 inhibitor. We found that trametinib increases the level of P15INK4b and Neurog2, suggesting a mechanism for how MEK1/2 inhibition induces neuronal differentiation. Oral administration of trametinib increased adult neurogenesis in the dentate gyrus and subventricular zone of the AD model mouse 5XFAD. Surprisingly, we also found that trametinib enhanced adult neurogenesis in the brain cortex. Consequently, trametinib rescued AD pathologies such as neuronal loss or cognitive impairment of 5XFAD mice. Finally, trametinib induced neurogenic differentiation of NSCs derived from AD patient iPSCs, which suggests its potential therapeutic application. Altogether, we suggest that restoration of endogenous adult neurogenesis by trametinib may be a promising therapeutic approach to AD.
The Influence of Shielding Gases on Keyhole-Induced Porosity and Nitrogen Absorption in SS 304 Stainless Steel Fiber Laser Welds
Authors: Hafez Khalid Mohamed 
Published: October 2022

Abstract
As regards porosity formation and gas content, choosing the appropriate shielding gas for laser welding is essential for achieving high-quality joints. Keyhole-induced porosity formation tendency and, nitrogen content in fiber laser SS 304 stainless steel welds were investigated based on shielding gas nitrogen contents in fiber laser welding. Beads-on-plate autogenous welds were made at 5 kW continuous wave (CW) fiber laser in N2 and Ar mixtures. Optical metallography, Micro-focused X-ray, X­ray radiography, and High-speed images of the molten pool were used to investigate the porosity formation. In addition, a gas analyzer was used to study the weld metal nitrogen content. The results show that nitrogen has a significant impact on the reduction of porosity in the melting zone, increases the dissolved nitrogen in the solidified weld metal, while almost no significant effect on the keyhole mode.
Extracellular Matrix Viscoelasticity Drives Liver Cancer Progression in Pre-Cirrhotic NASH
Authors: Török Natalie , Fan Weiguo , Adebowale Kolade , Li Yuan , Rabbi Md Foysal , Vancza Lorand , Chen Dongning , Kunimoto Koshi , Mozes Gergely , Li Yisi , Tao Junyan , Monga Satdarshan , Charville Gregory , Wells Rebecca , Dhanasekaran Renu , Kim Taeyoon , Chaudhuri Ovijit 
Published: October 2022

Abstract
Type 2 diabetes mellitus (T2DM) is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development, and increased stiffness is known to promote HCC progression in cirrhotic conditions. T2DM is characterized by an accumulation of advanced glycation end products (AGEs) in the ECM; however, how this affects HCC in non-cirrhotic conditions is unclear. Here, we find that in patients and animal models AGEs promote changes in collagen architecture and enhance ECM viscoelasticity, with greater viscous dissipation and faster stress relaxation, but not changes in stiffness. High AGEs and viscoelasticity combined with oncogenic β-catenin signaling promote HCC induction, while inhibiting AGEs production, reconstituting the clearance receptor AGER1, or breaking AGE-mediated collagen crosslinks reduce viscoelasticity and HCC growth. Matrix analysis and computational modeling demonstrate that lower interconnectivity of AGEs-bundled collagen matrix, marked by shorter fiber length and greater heterogeneity, enhances viscoelasticity. Mechanistically, animal studies and 3D cell cultures show that enhanced viscoelasticity promotes HCC cell proliferation and invasion through integrin β1–Tensin 1–YAP mechanotransduction pathway. These results reveal for the first time that AGEs-mediated structural changes enhance ECM viscoelasticity, and that viscoelasticity can drive cancer progression in vivo, independent of stiffness.
The role of surgery in relieving calcified shunt site related pain in patients with functioning VP shunt
Authors: Baig Rehman Ali , Davis James , Rodrigues Desiderio , Lo William , Kaliaperumal Chandrasekaran , Gallo Pasquale 
Published: October 2022

Abstract
Purpose

Shunt calcification is a known late sequela of ventriculoperitoneal (VP) shunt insertion and is associated with shunt malfunction. However, in some patients, while shunt functionality is preserved despite calcification of the catheters, they experience nociceptive symptoms. In this paper, the authors present their surgical experience in managing patients with a functional VP shunt and experiencing pain secondary to shunt calcification.

Methods

We analysed outcomes of patients presenting with pain at the level of a calcified shunt who underwent surgical untethering of the calcified catheter from the soft tissues. This procedure was commenced by the senior author in 2015. Patients were collected prospectively from the databases of two institutions. Evidence of shunt calcification was confirmed on neuroimaging.

Results

Seven patients, two male and five female were included. The mean age at untethering was 13.5 years. The mean time interval between primary shunt surgery and symptoms onset was twelve years (range 6–16 years). The commonest site of tethering was the neck (50%) followed by abdomen and chest (both 25%). Six patients underwent untethering of the catheter from soft tissues. One patient had removal of a redundant segment of calcified shunt left in situ during a previous revision. All patients experienced pain relief following shunt untethering.

Conclusion

Untethering of calcified VP shunt catheters from soft tissue can be considered an effective treatment of shunt site pain and offered to patients presenting with a functional VP shunt.