bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mycoplasma hominis and Ureaplasma urealyticum infections after knee arthroplasty: A case report
Authors: Luo Jingjing , Wu Xinan , Gang Xue , Zhang Nana , Wang Feifei , Rong Chengting 
Published: November 2022

Rationale:
Artificial joint infection caused by Mycoplasma hominis and Ureaplasma urealyticum is rare and has not been reported.

Patients concerns:
A 59-year-old man underwent left total knee arthroplasty for 1 year of pain in the left knee joint. The indwelling urinary catheter was removed after 48 hour of the surgery. On day 8 after the surgery, the patient had fever, increased skin temperature, swelling and redness around the surgical site, and floating patella test (+). According to experience, Vancomycin, Ciprofloxacin and Linezolid were administrated. Evident decrease in C-reactive protein was observed after Linezolid administration, while there was no significant improvement in clinical symptoms. Microbiome sequencing was performed, resulting in diagnosis of positive M hominis and U urealyticum. The patient was then treated with Doxycycline in the following 3 months. During the 11-month outpatient follow-up, there was no evidence of recurrence of infection.

Diagnosis:
Microbiome sequencing was performed, resulting in diagnosis of positive M hominis and Ureaplasma urealyticum.

Interventions:
The patient recovered following with Doxycycline in the following 3 months.

Outcomes:
During the 11-month outpatient follow-up, there was no evidence of recurrence of infection.

Lessons:

M hominis and U urealyticum are common pathogens of the urinary system infections but they are rare in osteoarticular infections. In cases of fever, swelling and heat pain around the surgical site, joint fluid, negative blood culture and being irresponsive to anti-bacterial agents against the cell wall, special bacteria-related infection should be highly suspected.
Paxlovid administration in elderly patient with COVID-19 caused by Omicron BA.2.0: A case report
Authors: Zhang Liulu , Zhang Shasha , Han Jing , Yi Yile , Zhou Hourong , Li Jianquan 
Published: November 2022

Rationale:
Paxlovid has shown the potential decreasing the hospitalization rate of mild or moderate coronavirus disease 2019 (COVID-19) and death in few of clinical trials, and is expected to the most promising medicine targeting Severe Acute Respiratory Syndrome Coronavirus 2 (SRAS-COV-2). However, there are no enough evidences to show it effectiveness for all patients with SARS-COV-2, especially among elderly patients and newest Omicron variant.

Patient concerns and diagnosis:
A 79 year’s old female patient was admitted to hospital because of the moderate COVID-19 caused by the Omicron variant BA2.0. He presented the initial syndromes including Xerostomia, cough and fever. Chest computed tomography (CT) scanning at admission showed the exudation lesions on lung. The laboratory examination revealed that there are increased C-reactive protein (CRP), Ferritin and erythrocytesedimentationrate (ESR) and decreased white blood cells.

Interventions:
The oral Paxlovid (Nirmatrelvir/Ritonavir) was administrated on second day after admission.

Outcomes:
The syndromes of Xerostomia, cough and fever was improved on third day after use of Paxlovid. The levels of CRP, ESR and counts of white blood cells returned the normal after three days of admission. The chest CT scanned on the third and sixth day after Paxlovid used showed the absorption of lesions. The examination of SARS-COVS viral nucleic acid turned negative at fifth day of admission.

Lessons:
As a result, we would consider that Paxlovid is a suitable oral drug for elderly patients with SARS-COV2 even Omicron variant, it’s benefit to improve patient’s symptom and signs and can prevents COVID-19 with the high-risk factors from severe disease, although it didn’t shorten the time for viral nucleic acid to turn negative.
Carotid arterial blowout after organ preserving chemoradiation therapy in hypopharyngeal cancer
Authors: Padua Paula Francezca , Fang Hsuan-Yeh , Young Chi-Kuan , Yeh Chih-Hua , Lin Chia-Chen , Liao Chun-Ta , Chang Tung-Chieh Joseph , Tsao Chung-Kan , Huang Shiang-Fu 
Published: November 2022

Laryngeal preserving concurrent chemoradiation has been advocated for hypopharyngeal cancers. The use of radiotherapy (RT) in the larynx could lead to increased rates of radionecrosis. In this study, we investigated a rare but disastrous complication, carotid blow-out syndrome (CBS), related with the persistent radionecrosis.
Retrospective cohort study.
This retrospective study enrolled hypopharyngeal cancer patients with biopsy-proven pharyngeal and laryngeal chondronecrosis (PLCRN), which was rated by the Chandler Grading System. From 2002 to 2018, a total of 346 hypopharygeal cancer patients received upfront radiation therapy, 13 PLCRN patients were identified in a rate of 3.8%. All PLRN patients received RT with a mean radiation dose of 70.81 ± 0.85 Gy. All patients had Chandler Grade IV at the time of presentation, which was a mean of 15.08 months (range: 5‐109 months) from the time of cancer diagnosis to PLCRN diagnosis. In 5 of the 13 PLCRN patients developed CBS. Three of the CBS originated from superior thyroid artery, one from lingual artery and one from the carotid artery. Three (60%) of the 5 CBS patients expired due to loss of airway and hemodynamic instability. Two (40%) were rescued by emergent airway secure and emergent angiographic embolization.
Persistent PLCRN could lead to disastrous vascular complications. CBSs were demonstrated to be more frequently originated from the branches of carotid artery rather than carotid artery per se. Clinical alert with early airway protection could strive for time to do interventions and prevent mortalities.
A fertility-sparing surgery in lymphoepithelioma-like carcinomas of the uterine cervix: A case report
Authors: Kim So Hee , Yoon Hyung Joon , Lee Nam Kyung , Choi Kyung Un , Kim Ki Hyung , Suh Dong Soo 
Published: November 2022

Introduction:
A poorly differentiated lymphoepithelioma-like carcinoma (LELC) of the cervix is an extremely rare presentation. We herein present an unusual case of LELC of the cervix, which was treated with radical trachelectomy for fertility preservation.

Patient concerns:
A 28-year-old female patient presented with a 1-month-history of post-coital vaginal bleeding, and a 2 cm tumor was found on gynecological sonography and magnetic resonance imaging.

Diagnosis:
The final pathological examination established a conclusive diagnosis of LELC of the cervix. After surgery, the patient was finally diagnosed as The International Federation of Gynecology and Obstetrics (FIGO) stage IB1 with no vaginal wall or parametrium infiltration.

Interventions:
Subsequently, a surgery was scheduled, and intraoperatively, we performed resection twice because of a frozen biopsy result that was resection margin-positive initially. As a result, further resection was performed, which was a 5mm thickness for each. Cisplatin adjuvant chemotherapy was administered 3 weeks after the operation to prevent recurrence.

Outcomes:
The patient has been followed for 1 year postoperatively, with an adjuvant treatment, with no evidence of tumor recurrence or metastasis.

Conclusion:
Based on this case, we highly recommend that operators should consider a deeper resection margin range than that visible on magnetic resonance imaging. More attention is needed to better understand the treatment method for LELC of the cervix. We also plan to closely monitor the patient’s prognosis and fertility, and to conduct additional studies.
How to choose the surgical side when cerebral blood flow and cerebrovascular response are contradictory in bilateral moyamoya disease?: A case report
Authors: Luo Mingrui , Yu Jin , Xin Can , Wan Lei , Zhang Jianjian 
Published: November 2022

Introduction:
Moyamoya disease (MMD) is a rare cerebrovascular disease characterized by progressive occlusion of the internal carotid artery and the secondary formation of collateral vessels. Bypass surgery is an effective treatment for MMD. Comprehensive evaluation of cerebral blood flow (CBF) and cerebrovascular response (CVR) is the common hemodynamic indication to surgery, the changes of which are usually identical.

The patient’s main concerns and important examinations:
We reported a rare case of MMD in a 34-year-old pregnant woman with transient ischemic attacks (TIAs) for 1 month, manifesting as frequent weakness in right limbs for several minutes without obvious cause. The diagnostic digital subtraction angiography (DSA) examination revealed Suzuki Grade I in left side and Grade IV in right side under modified Suzuki scoring. No-hyperventilation test single-photon emission computed tomography (no-HVT SPECT) showed more decreased CBF in the right side of the brain, but HVT SPECT demonstrated a more impaired CVR on the left side. Comprehensively, which side should be operated on is confusing when the changes of CVR and CBF are inconsistent.

The main diagnosis, therapeutics interventions, and outcomes:
The patient was diagnosed with bilateral MMD and underwent combined bypass surgery on the left side of the brain. The symptoms of admission were completely relieved after surgery and there were no further cerebrovascular events during the follow-up period of 4 months.

Conclusion:
CVR is a primary surgical indication of MMD, especially when the impairment of CVR and CBF are not consistent in the ipsilateral hemisphere. Meanwhile, HVT is the vital vasoactive challenges test for measuring CVR in MMD.
Identification of a rare missense mutation in GJB1 and prenatal diagnosis in a Chinese family with CMT: A case report
Authors: Huang Xinyi , Wu Xiaoli , Wu Bei , Mou Jing , Ma Xingwei 
Published: November 2022

Rationale:
Charcot-Marie-Tooth disease (CMT) is a highly heterogeneous genetic disorder. To date, more than 90 genes have been implicated in the pathogenesis of CMT. Here, we report the identification of a rare causative mutation in a Chinese family with CMT and a pregnant patient underwent prenatal diagnosis.

Patient concerns:
A 33-year-old woman with 21 + 6 weeks of pregnancy presented with progressive weakness of distal extremities after 23 years of age. A total of 8 individuals in 4 generations of her family had similar muscle weakness. On proband whole-exome sequencing (WES), a rare c.121G > A variant in the GJB1 gene was identified.

Diagnosis:
Based on the clinical and genetic findings, this patient was finally diagnosed with CMT.

Interventions:
The prenatal diagnosis was performed on the proband fetus.

Outcomes:
The fetus did not carry this rare variant, and the pregnancy continued.

Lessons:
Our findings provide the first clinical evidence for the causative role of GJB1 c.121G > A variant in CMT. WES is a valuable method for diagnosing patients with CMT.
Adenoid cystic carcinoma of the Bartholin’s gland is easily misdiagnosed: A case report and literature review
Authors: Wang Wenhui , Chen Hao , Guo Hualei , Chen Lei , Zhu Miaoping , Zhu Yingjia 
Published: November 2022

Rationale:
Adenoid cystic carcinoma (ACC) often occurs in the major and minor salivary glands and other sites containing secretory glands, while ACC of the Bartholin’s gland (BG-ACC) in the vulva is rare and easily misdiagnosed.

Patient concerns:
A 58-year-old female was referred to our hospital for further valuation of a mass occurring on the left side of her vulva. In the other hospital, the beginning of the period, local ultrasound showed a vulva mass, which was suspected to be a Bartholin’s gland cyst. Mixed neoplasms were considered in some biopsies. When transferred to our hospital, virtuous tumors were considered by ultrasound and magnetic resonance imaging. Pathology initially considered benign hyperplastic active tumor or borderline tumor.

Diagnoses:
Histological, immunochemical, and molecular tests confirmed a diagnosis of BG-ACC, negative surgical margin, without lymphatic metastasis.

Interventions:
Extended excision of the mass at left labia majora plus left inguinal lymph node dissection was performed.

Outcomes:
The patient received surgery therapy, no recurrence was observed during a 18-month follow-up period.

Lessons:
Due to its lack of specific characteristics in clinical, ultrasound and imaging, it is easy to be misdiagnosed, Due to its rarity and nonspecific clinical, radiologic and ultrasonographic manifestations, BG-ACC can be easily misdiagnosed. And its pathomorphological features overlap with other benign and malignant tumors occurring at vulva, BG-ACC can be easily misdiagnosed, and diagnosis by puncture biopsy is extremely difficult. Use of paraffin sections to identify tumor growth characteristics, combined with immunohistochemical findings, is the key to the diagnosis of ACC. In rare sites, MYB gene split are helpful in making a definite diagnosis.
Pseudo-malignant paranasal invasive aspergillosis showing bone destruction and FDG uptake on PET/CT: A case report
Authors: Tsuda Takeshi , Takeda Kazuya , Fujii Soichiro , Hayama Masaki , Inohara Hidenori 
Published: November 2022

Rationale:
Aspergillosis is a rare disease that often occurs in patients with diabetes mellitus or compromised hosts. This study describes a 60-years-old woman with unusual pseudo-malignant paranasal invasive aspergillosis with 18F-fluorodeoxyglucose (18F-FDG) uptake treated by endoscopic sinus surgery. To the best of our knowledge, there are few reported cases of paranasal fungal infection with 18F-FDG uptake.

Patients concerns:
A 60-years-old woman was presented with headache and nasal obstruction.

Diagnoses:
Computed tomography (CT) showed a shadow with bone destruction in the sinus cavity and accumulation of 18F-FDG uptake. The patient was diagnosed with a malignant tumor or pseudo-malignant paranasal invasive aspergillosis.

Interventions:
The patient underwent endoscopic sinus surgery; no neoplastic lesions were detected in the areas with CT shadows. All the observed fungal mass reservoirs were removed.

Outcomes:
The patient remained hospitalized for 1 week after the surgery with no significant postoperative abnormalities. There was no recurrence of the disease for 6 months, and the patient’s symptoms resolved, indicating a good course of follow-up.

Lessons:
Invasive aspergillosis should be considered a differential disease when positron emission tomography (PET)/CT scans show FDG uptake, CT shows bone destruction, and T2-weighted MRI scans show a low signal.
Comparison of the C-MAC D-blade video laryngoscope and the McCoy laryngoscope for double-lumen endotracheal tube intubation: A prospective randomized controlled study
Authors: Kim Kyung Mi , Seo Kwon Hui , Kim You Jung , John Hyunji , Moon Hyun Soo , Kim Namhyun , Yeon Nayoung 
Published: November 2022

Background:
Inserting a double-lumen endotracheal tube (DLT) poses more challenge than inserting a single-lumen tube. The C-MAC D-blade videolaryngoscope is a useful alternative to the direct laryngoscope. However, no study has compared its performance with that of the McCoy laryngoscope, which has a hyperangulated blade tip similar to that of the C-MAC D-blade. We aimed to compare the performance of the C-MAC D-blade videolaryngoscope with that of the McCoy laryngoscope in DLT intubation.

Methods:
In this prospective randomized controlled study, 90 patients requiring DLT intubation were randomly allocated to either the C-MAC D-blade videolaryngoscope group (group C, n = 47) or McCoy laryngoscope group (group M, n = 43). During intubation, the percentage of glottic opening, modified Cormack–Lehane grade, time taken for intubation, malposition of the bronchial lumen, and hemodynamic parameters were recorded. After intubation, we assessed the intubation difficulty scale score and, a postoperative sore throat in the recovery room.

Results:
The time taken for intubation was 35.85 ± 10.77 seconds and 33.18 ± 11.97 seconds in groups C and M, respectively (P = .269). The modified Cormack–Lehane grade was significantly lower in group C than in group M (P = .000). Percentage of glottic opening was significantly higher in group C (79.36 ± 13.42%) than in group M (53.49 ± 29.83%) (P = .000). The intubation difficulty scale score was significantly lower in group C than in group M (P = .030). There were no significant differences between the 2 groups in terms of malposition status, hemodynamic parameters, or visual analog scale score for a postoperative sore throat.

Conclusion:
Although the time taken for intubation was comparable between the 2 intubation devices, the C-MAC D-blade videolaryngoscope facilitated glottis visualization and reduced the intubation difficulty scale better than the McCoy laryngoscope in patients undergoing DLT intubation.
Long-term sequelae of COVID-19 (myalgic encephalomyelitis): An international cross-sectional study
Authors: Shaheen Nour , Shaheen Ahmed 
Published: November 2022

Background:
As a result of prolonged effects on multiple organs, recovery from COVID-19 caused by SARS-CoV-2 cannot be verified. This study seeks to understand chronic and acute long-term symptoms of COVID-19 lasting from a few weeks after diagnosis. The study also aims to gain insight into prevalence of chronic fatigue syndrome/myalgic encephalomyelitis, a potentially comorbid condition for several months after the infection, in addition to taking a broad perspective on rare symptoms that may have developed during or after the infection.

Study design:
Cross-sectional questionnaire\descriptive study.

Methods:
The questionnaire was developed to assess the long-term effects of the global pandemic of COVID-19 using DePaul Symptom Questionnaire-2. The DePaul Symptom Questionnaire, Patient Health Questionnaire, and other symptoms that have been introduced by literature review.

Discussion:
A large cohort of people from all over the world will be examined to understand the differential effects of people who have experienced COVID-19, as well as the potential occurrence of ME. In total, 20,000 COVID patients are expected to be included in the study by Sep 1, 2022. Patients who have experienced COVID-19 will be asked about their persistent symptoms from 1 week up to more than 6 months after catching or recovery from the infection.
Acupuncture-related techniques for prevention of type 2 diabetes mellitus in people with pre-diabetes: Protocol for a systematic review and meta-analysis
Authors: Guo Haoze , Wu Xingquan , Lei Siyuan , Wang Ying , Sun Weichen , Yang Qingwei , Song Bailin 
Published: November 2022

Background:
In modern society, the incidence of diabetes is increasing year by year. Most individuals pass through a phase of prediabetes before developing full blown diabetes. Acupuncture-related has been widely used in the treatment of diabetes, but there is no systematic review of acupuncture-related on the control of blood glucose in prediabetes. Therefore, this study aims to conduct a meta-analysis of the clinical efficacy of acupuncutre-related therapy in preventing the development of diabetes in patients with prediabetes.

Methods:
We will search Web of Science, The Cochrane Library, PubMed, Embase, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Wan-Fang Database, Chinese Scientific Journal Database (VIP Database) from their respective inception dates to September 1, 2022 to identify potentially eligible studies. We will use the Review Manager 5.4 software provided by the Cochrane Collaborative Network for statistical analysis. We then assessed the quality and risk of the included studies and observed the outcome measures.

Results:
This meta-analysis further elucidates the protective effects of acupuncture-related techniques on patients with prediabetes.

Conclusion:
The purpose of this meta-analysis was to investigate the effect of acupuncture- related techniques on blood glucose in patients with prediabetes, and to provide more methods for clinical prevention of conversion from prediabetes to diabetes.
Proteomes of Extracellular Vesicles From Pancreatic Cancer Cells and Cancer-Associated Fibroblasts
Authors: Pan Sharon , Lai Lisa A. , Simeone Diane M. , Dawson David W. , Yan Yuanqing , Crnogorac-Jurcevic Tatjana , Chen Ru , Brentnall Teresa A. 
Published: November 2022

Objectives
Extracellular vesicles (EVs) are lipid bound vesicles secreted by cells into the extracellular environment. Studies have implicated EVs in cell proliferation, epithelial-mesenchymal transition, metastasis, angiogenesis, and mediating the interaction of tumor cells and microenvironment. A systematic characterization of EVs from pancreatic cancer cells and cancer-associated fibroblasts (CAFs) would be valuable for studying the roles of EV proteins in pancreatic tumorigenesis.

Methods
Proteomic and functional analyses were applied to characterize the proteomes of EVs released from 5 pancreatic cancer lines, 2 CAF cell lines, and a normal pancreatic epithelial cell line (HPDE).

Results
More than 1400 nonredundant proteins were identified in each EV derived from the cell lines. The majority of the proteins identified in the EVs from the cancer cells, CAFs, and HPDE were detected in all 3 groups, highly enriched in the biological processes of vesicle-mediated transport and exocytosis. Protein networks relevant to pancreatic tumorigenesis, including epithelial-mesenchymal transition, complement, and coagulation components, were significantly enriched in the EVs from cancer cells or CAFs.

Conclusions
These findings support the roles of EVs as a potential mediator in transmitting epithelial-mesenchymal transition signals and complement response in the tumor microenvironment and possibly contributing to coagulation defects related to cancer development.
A relationship between Emotional intelligence and perceived parenting styles among undergraduate in Delhi University, India
Authors: Mishra Dipti , Singh Ranjana 
Published: November 2022

AbstractIntroductionEmotional Intelligence makes a major contribution and important factor in mental health. Parenting plays a pivotal role in training emotional intelligence because parents are responsible for the overall development of child. Not many studies have been done to find the association between emotional intelligence and parenting style. The objective of the study was to find the level of emotional intelligence in college students and if there is an association with perceived parenting style whether gender was as an effect modifier on the relationship between emotional intelligence and parenting style among young adults.MethodsThe study was conducted as a cross sectional study among college students in the age group of 18 to 24years. The study revealed that majority of the participants reported their parents parenting style as authoritative, followed by authoritarian.ResultThe proportion of authoritative father was 36% and authoritative mother was 37%. In this study the parenting style of mother was authoritative for both genders. The study results showed maternal authoritarian style (OR=0.3; 95%CI: 0.1, 0.5) and permissive style (OR=0.2; 95% CI: 0.2, 1.2) was negatively associated with high emotional quotient when compared to authoritative parenting style. Gender was an effect modifier in relationship between emotional intelligence and parenting style of father.ConclusionEmotional intelligence can be learned and modified and parents play a crucial rule in emotional development of child. They should acknowledge the developmental needs of child, listens to them, give them freedom and independence and also hold them accountable for their mistakes and behavior.