bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: An Evaluation of Optimal Friction Stir Welding Factors (FSWF) For Yellow Brass 405-20
Authors: Raza Syed Farhan , Khan Sarmad Ali , Habib Muhammad Salman , Ahmed Naveed , Ishfaq Kashif , Mehdi Ahmed 
Published: January 2022

Abstract

Friction stir welding (FSW) is a green, environmentally amicable, and solid-state joining technology. FSW can successfully weld a wide range of materials (similar/dissimilar parent materials) including aluminum, copper, steel, different alloys from these materials, plastics, composites. FSW of brass has already been accomplished by fewer researchers. In this research, yellow brass 405-20 is, therefore, welded with FSW that was never welded before. In this study, tool material utilized was M2 HSS that was also novel. Effect of two friction stir weld factors (FSWF), rotational speed (RS) and traverse speed (TS), was found on three output parameters i.e., weld temperature, weld strength and weld hardness. Weld temperature developed, was found to be 63.72% of melting point of base metal. A significant improvement in friction stir weld strength (FSWS) was also measured that was found to be 106.37% of the base brass strength. Finally, weld hardness was measured which was found to be 87.80% of original brass hardness. Based on main effects, optimal FSW factors were found to be 1450 rpm and 60 mm/min resulting interestingly in optimal temperature, optimal weld strength, and optimal hardness. Rotational speed (RS) was found to be significant to affect the weld temperature only at the friction stir weld zone (FSWZ) with the highest percent contribution (PCR) of 65.69%. However, PCR of transverse speed was found to be maximum for affecting weld strength as compared to its PCR towards both weld temperature and weld hardness. Current study was also deepened by microscopic investigation.
Comparative Analysis Over Tribology Characterization of TiAlN and TiAlSiN PVD Coating On Plasma Nitride Alloy 20
Authors: Sriniva R. Ganapathy , Palani S , Rajaravi C , Karthik S 
Published: January 2022

Abstract
The nickel-iron-chromium (alloy 20) is enriching by hybrid surface treatment through plasma nitride (PN) and physical vapor deposition (PVD) process. The plasma nitriding process takes 12 hours at 500°C. Potentiodynamic testing is used to characterize the corrosion performance of the treated material, followed by morphological analysis of the exposed surface; XRD, EDX, SEM, hardness, and tensile testing are used to investigate appropriate coating properties. Plasma nitride and hybrid PVD nickel-iron-chromium alloys exhibit perlite (γ + α ’) phases and martensite (γ + α) phases, respectively. The martensite microstructure ensures superior tensile strength and hardness. The pin-on-disc tribometer test proposes to analyze friction and hard-faced behavior in the dry sliding position. The inclusion of Si improves the adherent oxide film, resulting in a low wear rate in TiAlSiN alloy 20. Due to the presence of the passive film, TiAlSiN alloy 20 exposes the most passive region to attain better corrosion resistance.
Rapid Detection of Circulating Tumour DNA using Allele Specific Mini-Loop Mediated Isothermal Amplification
Authors: Allsopp Rebecca , Alexandrou Georgios , Toumazou Christofer , Ali Simak , Coombes Charles , Kalofonou Melpomeni , Shaw Jacqui 
Published: January 2022

Abstract
Isothermal amplification is an emerging approach for non-invasive, rapid and cost-effective real-time monitoring of cancer specific mutations through circulating tumour DNA (ctDNA). This study demonstrates a compact allele specific (AS) loop mediated isothermal amplification (LAMP) strategy, termed ‘AS-Mini-LAMP’, modelled using wild type (WT) and mutation specific reactions targeting the estrogen receptor ESR1 c.1138G>C (p.E380Q) missense mutation. Allele selectivity, encoded at the 5’-end of the forward and backward inner primers (FIP and BIP) promotes enhanced selectivity upon self-hybridisation, loop formation and self-primed exponential amplification. Inclusion of unmodified self-stabilising (USS) primers aimed to reduce the likelihood of non-specific allele amplification through competitive inhibition and to enhance reaction velocity through an assisted strand displacement ‘swarm’ priming effect. The two assays were optimised using short synthetic WT and E380Q mutant DNA templates, and subsequently validated to a limit of detection of 500 mutant copies in under 25 minutes in ddPCR-confirmed positive (20.7% variant allele frequency) and negative patient plasma cfDNA samples. These results demonstrate the ability of AS-Mini-LAMP to achieve sensitive and selective amplification of actionable mutations present within plasma ctDNA.
Investigation of the Relationship between MBP Gene Polymorphisms and Delayed Encephalopathy after Acute Carbon Monoxide Poisoning
Authors: Zhang Fan , Zeng Jiao , Zhang Xiaoli , Gu Jiapeng , Han Yongkai , Zhang Ping , Li Wenqiang , Gu Renjun 
Published: January 2022

Abstract
Background Increasing evidence reveals that delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) results from the combined effects of environmental and genetic factors. The main pathological feature of DEACMP was generalized demyelination of cerebral white matter. Myelin basic protein (MBP) levels in cerebrospinal fluid (CSF) and serum samples from DEACMP patients were elevated.Objectives This study investigated the association of MBP single nucleotide polymorphisms(SNPs) (rs470555, rs470724, rs4890785, rs595997, rs76452994, and rs921336) with DEACMP. Methods We genotyped 416 DEACMP patients and 785 age, educational level, and sex-matched ACMP patients for rs470555, rs470724, rs4890785, rs595997, rs76452994, and rs921336 SNPs using the Agena MassArray. Results There were no significant differences in the allele frequency distribution, four genetic models, and genotype distributions between the DEACMP and ACMP groups for rs470555, rs470724, rs4890785, and rs595997. However, significant differences were observed for rs76452994 and rs921336.Conclusions This study revealed that the MBP polymorphisms, rs470555, rs470724, rs4890785, and rs595997, were not associated with DEACMP. Based on the codominant, dominant, and overdominant genetic inheritability patterns, the MBP rs76452994 and rs921366 polymorphisms were associated with DEACMP. Furthermore, the G allele of rs76452994 and T allele of rs921336 could lead to higher DEACMP risk.
Identification of a Pyroptosis-Related lncRNA Risk Model for Predicting Prognosis and Immune Response in Colon Adenocarcinoma
Authors: Tan Yuying , Lu Liqing , Liang Xujun , Chen Yongheng 
Published: January 2022

Abstract
Background: Colon adenocarcinoma (COAD) is one of the most common malignant tumors and diagnosed at an advanced stage with poor prognosis in the world. Pyroptosis is involved in the initiation and progression of tumors. This research focused on constructing a pyroptosis-related ceRNA network to generate a reliable risk model for risk prediction and immune infiltration analysis of COAD.Methods: Transcriptome data, miRNA-sequencing data and clinical information were downloaded from the TCGA database. Firstly, differentially expressed mRNAs (DEmRNAs), miRNAs (DEmiRNAs), and lncRNAs (DElncRNAs) were identified to construct a pyroptosis-related ceRNA network. Secondly, a pyroptosis-related lncRNA risk model was developed applying univariate Cox regression analysis and least absolute shrinkage and selection operator method (LASSO) regression analysis. The Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses were utilized to functionally annotate RNAs contained in the ceRNA network. In addition, Kaplan-Meier analysis, receiver operating characteristic (ROC) curves, univariate and multivariate Cox regression, and nomogram were applied to validate this risk model. Finally, the relationship of this risk model with immune cells and immune checkpoint blockade (ICB) related genes were analyzed.Results: Totally 5373 DEmRNAs, 1159 DElncRNAs and 355 DEmiRNAs were identified. A pyroptosis-related ceRNA regulatory network containing 132 lncRNAs, 7miRNAs and 5 mRNAs was constructed and a ceRNA-based pyroptosis-related risk model including 11 lncRNAs was built. Tumor tissues were classified into high- and low- risk groups according to the median risk score. Kaplan-Meier analysis showed that the high-risk group had a shorter survival time; ROC analysis, independent prognostic analysis and nomogram further indicated the risk model was a significant independent prognostic factor which had excellent ability to predict patients’ risk. Moreover, immune infiltration analysis indicated that the risk model was related to immune infiltration cells (i.e., B cells naïve, T cells follicular helper, Macrophages M1, etc.) and ICB-related genes (i.e., PD-1, CTLA4, HAVCR2, etc).Conclusions: This pyroptosis-related lncRNA risk model possessed good prognostic value and the ability to predict the outcome of ICB immunotherapy in COAD.
Reactions to problems in marriage
Authors: İNANÇ Betul BATTALOĞLU 
Published: January 2022

Abstract
Purpose: Violence within the family is a common problem that can be seen in almost most socio-economic groups, societies, all ages and all educational levels. This study was planned to investigate the behavior and attitudes and marital satisfaction levels of the spouses in the family life process.Methods: All citizens 18 years and older that are living in households in the Republic of Turkey have been included. Considering the existing population records, a stratified two-stage systematic cluster sampling method was applied. . Comparisons by the sex, educational level, and marital status satisfied were performed with the use of chi-square and multivariate regression analysis, correlation analysis. A p-value <0.05 was considered to be statistically significant.Result: Violent behaviors such as doing harm, breaking and hitting things were more intense in men. Aply physical violence was more common among males. Only maintaining silence, getting angry or sulking was statistically significant in women (p <0.000). Yelling, scolding, humiliating, separating the bedroom and decreasing spending money was statistically significant in males (p <0.000).Conclusion: All concepts related to marriage should be well defined because spouse satisfaction and conflicts can have different meanings. It suggests that raising awareness about domestic violence against women, knowing solution methods, informing about their rights and increasing social support may be beneficial in solving the problem.
Computer-aided Efficient Design and Performance Optimization of Cutting Head for Roadheader
Authors: Jin Xin , Zhao Guochao , Zhao Lijuan , Lin Guocong 
Published: January 2022

Abstract
The cutting head is the core working mechanism of the roadheader for coal-rock materials cutting. The efficient and high performance design of cutting head is the key to improve the road head digging and mining technology. In this paper, based on cutting head design theory and virtual prototype technology, we propose a computer-aided structure design and performance optimization method for cutting head. We compile the calculation code and realize the reading and storing of relevant data through Excel. In particular, to obtain more realistic cutting performance data of the cutting head, we construct a coupling model of cutting head cutting rock wall based on virtual prototype technology, and then establish a database matching structural parameters, working parameters, coal-rock properties and cutting performance through extensive simulations. Based on the method, we complete the design of EBZ220 roadheader cutting head. We show that our method can realize the fast and efficient design of cutting head, and the designed cutting head has good working performance.
Novel Multifunctional NIR-II Aggregation-Induced Emission Nanoparticles Assisted Intraoperative Identification and Elimination of Residual Tumor
Authors: Qu Qiaojun , Zhang Zeyu , Guo Xiaoyong , Yang Junying , Cao Caiguang , Li Changjian , Xu Pengfei , Hu Zhenhua , Tian Jie 
Published: January 2022

Abstract
Incomplete tumor resection is the direct cause of the tumor recurrence and metastasis after surgery. Intraoperative accurate detection and elimination of microscopic residual cancer improve surgery outcomes. In this study, a powerful D1-π-A-D2-R type phototheranostic based on aggregation-induced emission (AIE)-active the second near-infrared window (NIR-II) fluorophore is designed and constructed. The prepared theranostic agent, A1 nanoparticles (NPs), simultaneously shows high absolute quantum yield (1.23%), excellent photothermal conversion efficiency (55.3%), high molar absorption coefficient and moderate singlet oxygen generation performance. In vivo experiments indicate that NIR-II fluorescence imaging of A1 NPs precisely detect microscopic residual tumor (2 mm in diameter) in the tumor bed and metastatic lymph nodes. More notably, a novel integrated strategy that achieves complete tumor eradication (no local recurrence and metastasis after surgery) is proposed. In summary, A1 NPs possess superior imaging and treatment performance, and can detect and eliminate residual tumor lesions intraoperatively. This work provides a promising technique for future clinical applications achieving improved surgical outcomes.
Guideline Adherence and Implementation of Tumor Board Therapy Recommendations for Patients With Gastrointestinal Cancer
Authors: Krause Alina , Stocker Gertraud , Gockel Ines , Seehofer Daniel , Hoffmann Albrecht , Bläker Hendrik , Dennecke Timm , Kluge Regine , Lordick Florian , Knoedler Maren 
Published: January 2022

Abstract
Purpose: Although participation in multidisciplinary tumor boards (MTBs) is an obligatory quality criterion for certification, there is scarce evidence, whether MTB recommendations are consistent with consensus guidelines and whether they are followed in clinical practice. Reasons of guideline and tumor board deviations are poorly understood so far. Methods: MTBs recommendations from the weekly MTB for gastrointestinal cancers at the University Cancer Center Leipzig/Germany (UCCL) in 2020 were analyzed for their adherence to therapy recommendations as stated in National German guidelines and implementation within an observation period of 3 months. To assess adherence, an objective classification system was developed assigning a degree of guideline and tumor board adherence to each MTB case. For cases with deviations, underlying causes and influencing factors were investigated and categorized. Results: 76% of MTBs were fully adherent to guidelines, with 16% showing deviations, mainly due to study inclusions and patient comorbidities. Guideline adherence in 8% of case discussions could not be determined, especially because there was no underlying guideline recommendation for the specific topic. Full implementation of the MTBs treatment recommendation occurred in 64% of all cases, while 21% showed deviations with primarily reasons of comorbidities and differing patient wishes. Significantly lower guideline and tumor board adherences were demonstrated in patients with reduced performance status (ECOG-PS ≥ 2) and for palliative intended therapy (p=.002/.007). Conclusion: The assessment of guideline deviations and adherence to MTB decisions by a systematic and objective quality assessment tool could become a meaningful quality criterion for cancer centers in Germany.
Detection Of Surface Defects And Subsurface Defects Of Polished Optics With Multisensor Image Fusion
Authors: Sun Huanyu , Wang Shiling , Hu Xiaobo , Liu Hongjie , Zhou Xiaoyan , Huang Jin , Cheng Xinglei , Sun Feng , Liu Yubo , Liu Dong 
Published: January 2022

Abstract
Surface defects (SDs) and subsurface defects (SSDs) are the key factors decreasing the laser damage threshold of optics. Due to the spatially stacked structure, accurately detecting and distinguishing them has become a major challenge. Herein a detection method for SDs and SSDs with multisensor image fusion is proposed. The optics is illuminated by a laser under dark field condition, and the defects are excited to generate scattering and fluorescence lights, which are received by two image sensors in a wide-field microscope. With the modified algorithms of image registration and feature-level fusion, different types of defects are identified and extracted from the scattering and fluorescence images. Experiments show that two imaging modes can be realized simultaneously by multisensor image fusion, and HF etching verifies that SDs and SSDs of polished optics can be accurately distinguished. This method provides a more targeted reference for the evaluation and control of the defects of optics, and exhibits potential in the application of material surface research.
A New Approach to Mixed/Boundary Friction Prediction Using the Logistics Curve
Authors: Taylor Robert Ian , Sherrington Ian 
Published: January 2022

Abstract
There is a strong focus on improving the energy efficiency of machines. Over the last 20-30 years, one way to improve energy efficiency has been to reduce lubricant viscosity. This also has the effect of leading to thinner oil films between the machine’s moving surfaces and is likely to lead to increased mixed/boundary friction. Accurately predicting friction in the mixed/boundary friction regime is therefore becoming of great importance. The work reported here suggests that commonly used asperity friction models significantly underestimate friction in the mixed/boundary friction, and a new model, based on a logistic curve fit, gives a better estimate of mixed/boundary friction, provides good agreement with experimental friction data (from Mini Traction Machine experiments), and is much more straightforward for engineers and tribologists to apply for the estimation of mixed/boundary friction losses.
Auxora Vs. Placebo for the Treatment of Patients with Severe COVID-19 Pneumonia: A Randomized Clinical Trial
Authors: Bruen Charles , Al-Saadi Mukhtar , Michelson Edward , Tanios Maged , Mendoza-Ayala Raul , Miller Joseph , Zhang Jeffrey , Stauderman Kenneth , Hebbar Sudarshan , Hou Peter 
Published: January 2022

Abstract
Background: Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia. Methods: CARDEA was a phase 2, randomized, double-blind, placebo-controlled trial evaluating the addition of Auxora, a CRAC channel inhibitor, to corticosteroids and standard of care in adults with severe COVID-19 pneumonia. The primary endpoint was time to recovery through Day 60, with secondary endpoints of all-cause mortality at Day 60 and Day 30. Due to declining rates of COVID-19 hospitalizations and encroachment of prohibited medications as standard of care, the trial was stopped early. Results: The pre-specified efficacy set consisted of the 261 patients with a baseline imputed PaO2/FiO2 £200 with 130 and 131 in the Auxora and placebo groups, respectively. Time to recovery was 7 vs. 10 days (P=0.0979) for patients who received Auxora vs. placebo, respectively. The all-cause mortality rate at Day 60 was 13.8% with Auxora vs. 20.6% with placebo (P=0.1449); Day 30 all-cause mortality was 7.7% and 17.6%, respectively (P=0.0165). Similar trends were noted in patients on high flow nasal cannula at baseline or those with a baseline imputed PaO2/FiO2 ≤100. Serious adverse events occurred less frequently in patients treated with Auxora vs. placebo. Conclusions: Auxora was safe and well tolerated with strong signals in both time to recovery and all-cause mortality through Day 60 in patients with severe COVID-19 pneumonia. Further studies of Auxora in combination with corticosteroids and other immunomodulatory agents are warranted.Trial registration: NCT04345614
SARS-CoV-2 Omicron Outbreak in a Dormitory in Saint-Petersburg, Russia
Authors: Bazykin Georgii A. , Danilenko Daria M. , Komissarov Andrey B. , Yolshin Nikita , Shneider Olga V. , Nabieva Elena , Klink Galya V. , Shvyrev Nikita , Konovalova Nadezhda , Zheltukhina Alyona , Fadeev Artem , Komissarova Kseniya , Ksenafontov Andrey , Musaeva Tamila , Eder Veronica , Shchur Vladimir , Lioznov Dmitry 
Published: January 2022

Abstract
The B.1.1.529 Omicron variant of SARS-CoV-2 is rapidly spreading, displacing the globally prevalent Delta variant. Before December 16, 2021, community transmission had already been observed in tens of countries globally. However, in Russia, all reported cases had been sporadic and associated with travel. Here, we report an Omicron outbreak at a students’ dormitory in Saint Petersburg, Russia. Out of the 462 sampled residents of the dormitory, 206 (44.6%) tested PCR positive, and 159 (77.1%) of these infections carried the S:ins214EPE insertion, indicating that they were of the Omicron strain. 104 (65%) of Omicron-positive patients have been vaccinated and/or reported previous covid-19. Whole genome sequencing confirmed that the outbreak is caused by the Omicron variant. Phylogenetic analysis showed that the outbreak has a single origin, and belongs to the S:346K sublineage of Omicron which may be characterized by an increased rate of spread, compared to other Omicron sublineages. The rapid spread of Omicron in a population with preexisting immunity to previous variants underlines its propensity for immune evasion.
Simulating Regional Cassava Yield Gap in Nigeria
Authors: Srivast Amit Kumar , Gaiser Thomas , Akinwumiju Akinola Shola , Zeng Wenzhi , Ceglar Andrej , Ezui Kodjovi Senam , Ewert Frank , Adelodun Adedeji , Adebayo Abass , Sobamowo Jumoke , Singh Manmeet , Rahimi Jaber 
Published: January 2022

Abstract
Cassava production is essential for food security in Sub-Saharan Africa and serves as a major calorie- intake source in Nigeria. Here we use a crop model, LINTUL5, embedded into a modeling framework SIMPLACE to estimate potential cassava yield gaps (Yg) in 30 states of Nigeria. Our study of climate parameter influence on the variability of current and potential yields and Yg shows that cumulative radiation and precipitation were the most significant factors associated with cassava yield variability (p = 0.01). The cumulative Yg mean was estimated as 18202 kg∙ha-1, with a maximum of 31207 kg ha-1 in Kano state. Across the states, nutrient limitation accounts for 55.3% of the total cassava yield gap, while the remaining 44.7% is attributed to water limitation. The highest untapped water-limited yields were estimated in States, such as Bauchi, Gombe, and Sokoto, characterized by the short rainy season. Conclusively, the current cassava yield levels can be increased by a factor of five through soil fertility enhancement and with irrigation, particularly in semi-arid regions.