bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diet quality as assessed by Healthy Eating Index-2015 among Hungarian Roma living in settlements of Northeast Hungary
Authors: Bárdos Helga , Llanaj Erand , Vincze Ferenc , Diószegi Judit , Pikó Péter , Kósa Zsigmond , Sándor János , Ádány Róza 
Published: November 2022

AbstractInequalities in diet quality are increasingly reported, but such studies among Roma are scarce and challenging. Here we attempt to examine diet quality and adherence to food based dietary guidelines among Hungarian Roma (HR) ethnic minority living in segregated settlements while comparing a sample of Hungarian adults from the general population (HG). Data were obtained from a complex comparative health survey conducted in Northeast Hungary in 2018, including sociodemographic and physical examination data. Dietary data were collected using two non-consecutive 24-h dietary recalls. We assessed diet quality based on using a 13-component Healthy Eating Index-2015 (HEI-2015, range 0–100). Differences in median intakes of food and nutrients and HEI-2015 scores were evaluated by Mann–Whitney test or Kruskal–Wallis test. Quantile regression was used to adjust HEI-2015 scores for socioeconomic factors including age, sex, educational status, and perceived financial status. This analysis included 393 and 415 subjects, aged between 18 to 70 years, of HR and HG populations, respectively. Results showed overall low median HEI-2015 scores for both HR and HG, with significantly lower total score among HR participants (41.6, interquartile range (IQR): 39.5–42.8) compared to HG (47.2, IQR: 45.7–51.1). Scores for individual components, such as intake of fruits, greens and beans, whole grains, seafood, and plant proteins were particularly suboptimal among both groups, but significantly lower among the HR population. Scores for refined grains, sodium, saturated fats and added sugar reflected high intakes of these components but did not differ between study groups. Our findings revealed an unfavorable diet quality among the HR compared to HG and a potentially increased risk for diet-related NCDs. Future health intervention programs are warranted to address dietary disparities of segregated minorities in Hungary while considering ethnic and cultural differences.
Effect of playing position and microcycle days on the acceleration speed profile of elite football players
Authors: Alonso-Callejo Antonio , García-Unanue Jorge , Perez-Guerra Andrés , Gomez David , Sánchez-Sánchez Javier , Gallardo Leonor , Oliva-Lozano Jose María , Felipe Jose Luis 
Published: November 2022

AbstractThe aim of this study was to analyse the differences in the A–S profile of elite football players induced by playing position and the microcycle day. Players belonged to a second division club in the Spanish La Liga competition. They were classified into five playing positions: central defenders (CD), full backs (FB), midfielders (MF), wide midfielders (WMF) and forwards (FW). Microcycle days were categorised according to the days until matchday (MD, MD-1, MD-2, MD-3, MD-4 and MD-5). Data was collected along six microcycles, including one match per microcycle. The variables analysed were: maximal theoretical acceleration (A0), maximal theoretical speed (S0), maximal acceleration (ACCmax), maximal speed (Smax) and A–S slope (ASslope). Significant differences were found within positions and microcycle day for all variables (p < 0.05). Match day (MD) showed greater values than the training sessions in A0, ACCmax and Smax (p < 0.05). The highest values for variables associated with acceleration capabilities were found in CD on MD, whereas speed variables were higher in WMF. MD-2 showed the lowest values in all variables except for ASslope. Maximal acceleration and sprint abilities are therefore affected by playing position. Wide positions showed the highest speed capacity, and CD presented a likely acceleration profile. Higher values for all variables concerning the microcycle day, were achieved on MD, and were not reproduced during training with the consequent injury risk and performance decrease it takes.
Intraprocedural endothelial cell seeding of arterial stents via biotin/avidin targeting mitigates in-stent restenosis
Authors: Alferiev Ivan S. , Hooshdaran Bahman , Pressly Benjamin B. , Zoltick Philip W. , Stachelek Stanley J. , Chorny Michael , Levy Robert J. , Fishbein Ilia 
Published: November 2022

AbstractImpaired endothelialization of endovascular stents has been established as a major cause of in-stent restenosis and late stent thrombosis. Attempts to enhance endothelialization of inner stent surfaces by pre-seeding the stents with endothelial cells in vitro prior to implantation are compromised by cell destruction during high-pressure stent deployment. Herein, we report on the novel stent endothelialization strategy of post-deployment seeding of biotin-modified endothelial cells to avidin-functionalized stents. Acquisition of an avidin monolayer on the stent surface was achieved by consecutive treatments of bare metal stents (BMS) with polyallylamine bisphosphonate, an amine-reactive biotinylation reagent and avidin. Biotin-modified endothelial cells retain growth characteristics of normal endothelium and can express reporter transgenes. Under physiological shear conditions, a 50-fold higher number of recirculating biotinylated cells attached to the avidin-modified metal surfaces compared to bare metal counterparts. Delivery of biotinylated endothelial cells to the carotid arterial segment containing the implanted avidin-modified stent in rats results in immediate cell binding to the stent struts and is associated with a 30% reduction of in-stent restenosis in comparison with BMS.
Au L-shell x-ray emission induced by 154.3–423.9 MeV/u C6+ ions
Authors: Zhou Xianming , Wei Jing , Cheng Rui , Zhang Yanning , Chen Yanhong , Liang Changhui , Zhang Xiaoan , Zhao Yongtao 
Published: November 2022

AbstractThe L-shell x-ray emissions of gold are investigated for the bombardment of high energy C6+ ions in the high energy region of 154.3–423.9 MeV/u. Due to the multiple ionization of outer-shell electrons at the movement of L x-ray emission, the blue shift of the experimental x-ray energy and an enhancement of the relative intensity ratios of Lι, Lβ–Lα x rays are observed. Using the improved thin target formula and considering the effect of multiple ionization on atomic parameters, the L-subshell x-ray production cross sections are extracted from the counts and compared with the theoretical estimations of BEA, PWBA and ECPSSR. It is found that the relative corrections of ECPSSR on PWBA can be ignored in the present experimental energy region. The calculations of PWBA and ECPSSR are almost identical and both are larger than the experimental results. The BEA is in better agreement with the experiment as a whole.
The antimicrobial, antibiofilm, and wound healing properties of ethyl acetate crude extract of an endophytic fungus Paecilomyces sp. (AUMC 15510) in earthworm model
Authors: Salem Shimaa H. , El-Maraghy Saad S. , Abdel-Mallek Ahmed Y. , Abdel-Rahman Mohamed A. A. , Hassanein Emad H. M. , Al-Bedak Osama A. , El-Aziz Fatma El-Zahraa A. Abd 
Published: November 2022

AbstractThe endophytic fungus Paecilomyces sp. (AUMC 15510) was isolated from healthy stem samples of the Egyptian medicinal plant Cornulaca monacantha. We used GC–MS and HPLC analysis to identify the bioactive constituents of ethyl acetate crude extract of Paecilomyces sp. (PsEAE). Six human microbial pathogens have been selected to evaluate the antimicrobial activity of PsEAE. Our data showed that the extract has significant antimicrobial activity against all tested pathogens. However, the best inhibitory effect was observed against Bacillus subtilis ATCC 6633 and Pseudomonas aeruginosa ATCC 90274 with a minimum inhibitory concentration (MIC) of 3.9 μg/ml and minimum bactericidal concentration (MBC) of 15.6 μg/ml, for both pathogens. Also, PsEAE exerts a significant inhibition on the biofilm formation of the previously mentioned pathogenic strains. In addition, we evaluated the wound healing efficiency of PsEAE on earthworms (Lumbricus castaneus) as a feasible and plausible model that mimics human skin. Interestingly, PsEAE exhibited a promising wound healing activity and enhanced wound closure. In conclusion, Paecilomyces sp. (AUMC 15510) could be a sustainable source of antimicrobial agents and a potential therapeutic target for wound management.
Image local structure information learning for fine-grained visual classification
Authors: Lu Jin , Zhang Weichuan , Zhao Yali , Sun Changming 
Published: November 2022

AbstractLearning discriminative visual patterns from image local salient regions is widely used for fine-grained visual classification (FGVC) tasks such as plant or animal species classification. A large number of complex networks have been designed for learning discriminative feature representations. In this paper, we propose a novel local structure information (LSI) learning method for FGVC. Firstly, we indicate that the existing FGVC methods have not properly considered how to extract LSI from an input image for FGVC. Then an LSI extraction technique is introduced which has the ability to properly depict the properties of different local structure features in images. Secondly, a novel LSI learning module is proposed to be added into a given backbone network for enhancing the ability of the network to find salient regions. Thirdly, extensive experiments show that our proposed method achieves better performance on six image datasets. Particularly, the proposed method performs far better on datasets with a limited number of images.
Phenol- and resorcinol-appended metallocorroles and their derivatization with fluorous tags
Authors: Alemayehu Abraham B. , Ghosh Abhik 
Published: November 2022

AbstractBoron tribromide-mediated demethylation of rhenium-oxo and gold meso-tris(4-methoxyphenyl)corrole and meso-tris(3,5-dimethoxyphenylcorrole), M[TpOMePC] and M[T(3,5-OMe)PC] (M = ReO, Au), have yielded the corresponding phenol- and resorcinol-appended metallocorroles, M[TpOHPC] and M[T(3,5-OH)PC], in good yields. The latter compounds proved insoluble in dichloromethane and chloroform but soluble in THF. The M[T(3,5-OH)PC] derivatives also proved moderately soluble in 0.05 M aqueous KOH. Unlike oxidation-prone aminophenyl-substituted corroles, the phenol- and resorcinol-appended metallocorroles could be readily handled in air without special precautions. The phenolic metallocorroles could be readily alkylated with 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl iodide (“FtI”) to afford the fluorous-tagged metallocorroles M[TpOFtPC] and M[T(3,5-OFt)PC] in > 90% yields. The simplicity of the synthetic protocols promise a wide range of phenolic and fluorous-tagged porphyrin analogues with potential applications to diverse fields such as sensors, catalysis, and photodynamic therapy, among others.
Predicting health crises from early warning signs in patient medical records
Authors: Gumustop Selin , Gallo-Bernal Sebastian , McPeake Fionnuala , Briggs Daniel , Gee Michael S. , Pianykh Oleg S. 
Published: November 2022

AbstractThe COVID-19 global pandemic has caused unprecedented worldwide changes in healthcare delivery. While containment and mitigation approaches have been intensified, the progressive increase in the number of cases has overwhelmed health systems globally, highlighting the need for anticipation and prediction to be the basis of an efficient response system. This study demonstrates the role of population health metrics as early warning signs of future health crises. We retrospectively collected data from the emergency department of a large academic hospital in the northeastern United States from 01/01/2019 to 08/07/2021. A total of 377,694 patient records and 303 features were included for analysis. Departing from a multivariate artificial intelligence (AI) model initially developed to predict the risk of high-flow oxygen therapy or mechanical ventilation requirement during the COVID-19 pandemic, a total of 19 original variables and eight engineered features showing to be most predictive of the outcome were selected for further analysis. The temporal trends of the selected variables before and during the pandemic were characterized to determine their potential roles as early warning signs of future health crises. Temporal analysis of the individual variables included in the high-flow oxygen model showed that at a population level, the respiratory rate, temperature, low oxygen saturation, number of diagnoses during the first encounter, heart rate, BMI, age, sex, and neutrophil percentage demonstrated observable and traceable changes eight weeks before the first COVID-19 public health emergency declaration. Additionally, the engineered rule-based features built from the original variables also exhibited a pre-pandemic surge that preceded the first pandemic wave in spring 2020. Our findings suggest that the changes in routine population health metrics may serve as early warnings of future crises. This justifies the development of patient health surveillance systems, that can continuously monitor population health features, and alarm of new approaching public health crises before they become devastating.
Effect of light at different wavelengths on polyol synthesis of silver nanocubes
Authors: Gheitaran Rasoul , Afkhami Abbas , Madrakian Tayyebeh 
Published: November 2022

AbstractDespite the presence of light-sensitive species in the polyol synthesis of silver nanocubes, the influence of light on it has yet to be investigated. Herein, we demonstrated that light radiation, by generating plasmon-based hot electrons and subsequently increasing the reduction rate of Ag+ in the system, in addition to enhancing the growth rate of nanocubes, causes twinned seeds, which these seeds are then converted into nanorods and right bipyramids. With shorter, higher energy wavelengths, Ag+ reduction progresses more quickly, resulting in structures with more twin planes. The overlap of the excitation wavelength and the band gap of Ag2S clusters formed in the early stages of synthesis accelerates the rate of reaction at low-energy excitation. According to our findings, the surfactant polyvinylpyrrolidone acts as a photochemical relay to drive the growth of silver nanoparticles. Overall, this work emphasizes the impact of excitation light on polyol synthesis as a technique for generating Ag nanocubes of various sizes.
Single-cell transcriptomics reveals cellular heterogeneity and molecular stratification of cervical cancer
Authors: Li Chunbo , Wu Hao , Guo Luopei , Liu Danyang , Yang Shimin , Li Shengli , Hua Keqin 
Published: November 2022

AbstractCervical cancer (CC) is the most common gynecological malignancy, whose cellular heterogeneity has not been fully understood. Here, we performed single-cell RNA sequencing (scRNA-seq) to survey the transcriptomes of 57,669 cells derived from three CC tumors with paired normal adjacent non-tumor (NAT) samples. Single-cell transcriptomics analysis revealed extensive heterogeneity in malignant cells of human CCs, wherein epithelial subpopulation exhibited different genomic and transcriptomic signatures. We also identified cancer-associated fibroblasts (CAFs) that may promote tumor progression of CC, and further distinguished inflammatory CAF (iCAF) and myofibroblastic CAF (myCAF). CD8+ T cell diversity revealed both proliferative (MKI67+) and non-cycling exhausted (PDCD1+) subpopulations at the end of the trajectory path. We used the epithelial signature genes derived from scRNA-seq to deconvolute bulk RNA-seq data of CC, identifying four different CC subtypes, namely hypoxia (S-H subtype), proliferation (S-P subtype), differentiation (S-D subtype), and immunoactive (S-I subtype) subtype. The S-H subtype showed the worst prognosis, while CC patients of the S-I subtype had the longest overall survival time. Our results lay the foundation for precision prognostic and therapeutic stratification of CC.
Prostaglandin E2 receptor Ptger4b regulates female-specific peptidergic neurons and female sexual receptivity in medaka
Authors: Fleming Thomas , Kikuchi Yukiko , Nakajo Mikoto , Tachizawa Masaya , Inazumi Tomoaki , Tsuchiya Soken , Sugimoto Yukihiko , Saito Daisuke , Suyama Mikita , Ohkawa Yasuyuki , Baba Takashi , Morohashi Ken-ichirou , Okubo Kataaki 
Published: November 2022

AbstractIn vertebrates, female receptivity to male courtship is highly dependent on ovarian secretion of estrogens and prostaglandins. We recently identified female-specific neurons in the medaka (Oryzias latipes) preoptic area that express Npba, a neuropeptide mediating female sexual receptivity, in response to ovarian estrogens. Here we show by transcriptomic analysis that these neurons express a multitude of neuropeptides, in addition to Npba, in an ovarian-dependent manner, and we thus termed them female-specific, sex steroid-responsive peptidergic (FeSP) neurons. Our results further revealed that FeSP neurons express a prostaglandin E2 receptor gene, ptger4b, in an ovarian estrogen-dependent manner. Behavioral and physiological examination of ptger4b-deficient female medaka found that they exhibit increased sexual receptivity while retaining normal ovarian function and that their FeSP neurons have reduced firing activity and impaired neuropeptide release. Collectively, this work provides evidence that prostaglandin E2/Ptger4b signaling mediates the estrogenic regulation of FeSP neuron activity and female sexual receptivity.
Elastic orbital angular momentum transfer from an elastic pipe to a fluid
Authors: Chaplain Gregory James , De Ponti Jacopo Maria , Starkey Timothy Andrew 
Published: November 2022

AbstractResearch into the orbital angular momentum carried by helical wave-fronts has been dominated by the fields of electromagnetism and acoustics, owing to its practical utility in sensing, communication, and tweezing. Despite the huge research effort across the wave community, only recently has elastic orbital angular momentum been theoretically shown to exhibit similar properties. Here we experimentally observe the transfer of elastic orbital angular momentum from a hollow elastic pipe to a fluid in which the pipe is partially submerged, in an elastic analogue of Durnin’s slit-ring experiment for optical beams. This transfer is achieved by coupling the dilatational component of guided flexural waves in the pipe with the pressure field in the fluid; the circumferential distribution of the normal stress in the pipe acts as a continuous phased pressure source in the fluid resulting in the generation of Bessel-like acoustic beams. This demonstration has implications for future research into a new regime of orbital angular momentum for elastic waves, as well providing an alternative method to excite acoustic beams that carry orbital angular momentum that could create a paradigm shift for acoustic tweezing.
Spatially consistent microbial biomass and future cellular carbon release from melting Northern Hemisphere glacier surfaces
Authors: Stevens Ian T. , Irvine-Fynn Tristram D. L. , Edwards Arwyn , Mitchell Andrew C. , Cook Joseph M. , Porter Philip R. , Holt Tom O. , Huss Matthias , Fettweis Xavier , Moorman Brian J. , Sattler Birgit , Hodson Andy J. 
Published: November 2022

AbstractMelting glacier ice surfaces host active microbial communities that enhance glacial melt, contribute to biogeochemical cycling, and nourish downstream ecosystems; but these communities remain poorly characterised. Over the coming decades, the forecast ‘peak melt’ of Earth’s glaciers necessitates an improvement in understanding the state and fate of supraglacial ecosystems to better predict the effects of climate change upon glacial surfaces and catchment biogeochemistry. Here we show a regionally consistent mean microbial abundance of 104 cells mL−1 in surface meltwaters from eight glaciers across Europe and North America, and two sites in western Greenland. Microbial abundance is correlated with suspended sediment concentration, but not with ice surface hydraulic properties. We forecast that release of these microbes from surfaces under a medium carbon emission scenario (RCP 4.5) will deliver 2.9 × 1022 cells yr−1, equivalent to 0.65 million tonnes yr−1 of cellular carbon, to downstream ecosystems over the next ~80 years.
The Effect of a Climate Event on Voice-Related Processes in Seniors
Authors: Smith Bonnie E. , Bahr Ruth Huntley 
Published: November 2022

Purpose:
This project considered the relationship of harmful algal blooms, specifically red tide, to patient reports of respiratory diseases, use of respiratory medications, reflux symptoms, excessive coughing/throat clearing, water consumption, voice handicap scores, clinician judgments of voice quality, and voice therapy outcomes in senior voice patients in coastal Southwest Florida.

Method:
A retrospective chart review of 131 seniors receiving voice therapy during 2013–2019 was conducted. Patients formed two groups—those evaluated during periods of high versus low red tide. Patient reports, clinician ratings, and therapy outcomes were analyzed with nonparametric statistics to determine differences between patient groups.

Results:
No relationship was found between the presence of high red tide and reports of airway disorders, use of airway medications, coughing/throat clearing, Reflux Symptom Index scores, or voice therapy success. A significant relationship was found between high red tide months and ratings of voice severity and Voice Handicap Index scores.

Conclusions:
Harmful algal blooms may have negatively impacted the voices of seniors in this study, as shown by higher clinician voice severity ratings and higher patient perceptions of voice handicap during periods of high red tide. While voice success was still achieved by many of these seniors, speech-language pathologists should be aware of environmental issues and their possible negative impacts on voice.
Incorporating Flexible Endoscopic Evaluation of Swallowing Rating Scales Into Clinical Practice
Authors: Starmer Heather M. 
Published: November 2022

Purpose:
Flexible endoscopic evaluation of swallowing (FEES) is an important diagnostic tool used in the management of patients with dysphagia. In order to optimize the standardization, reliability, and validity of ratings, it is suggested that formal rating scales be integrated into clinical practice and documentation. In this clinical focus article, we will review extant rating scales for FEES exams and discuss strategies to integrate them into clinical practice.

Conclusions:
Rating scales for FEES take into consideration parameters of safety, efficiency, and overall swallowing impairment. Integrating such measures into clinical documentation helps to increase the standardization and comparability of clinical documentation.
Zonotope and Gaussian Kalman filters based state estimation algorithm for linear system with dual noise term
Authors: Zhan Yacong , Wang Ziyun , Wang Yan , Park Ju H. , Ji Zhicheng 
Published: November 2022

AbstractTo solve the problem of state estimation for systems with dual noise terms, a zonotope and Gaussian Kalman filters based state estimation algorithm is proposed. A state estimator is designed to obtain the estimation interval of the true state in the presence of both stochastic and unknown but bounded (UBB) uncertainties. A novel coefficient that weighs the relative influence of stochastic and UBB uncertainties is introduced, and the optimal weight solution is introduced by minimizing the polyhedron space and mean square error. Finally, two simulation examples are presented to demonstrate the accuracy and effectiveness of the proposed algorithm.