bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-Channel Local Binary Pattern Guided Convolutional Neural Network for Breast Cancer Classification
Authors: Mewada Hiren , Al-Asad Jawad F. , Patel Amit , Chaudhari Jitendra , Mahant Keyur , Vala Alpesh 
Published: January 2022

Background:
The advancement in convolutional neural network (CNN) has reduced the burden of experts using the computer-aided diagnosis of human breast cancer. However, most CNN networks use spatial features only. The inherent texture structure present in histopathological images plays an important role in distinguishing malignant tissues. This paper proposes an alternate CNN network that integrates Local Binary Pattern (LBP) based texture information with CNN features.

Methods:
The study propagates that LBP provides the most robust rotation, and translation-invariant features in comparison with other texture feature extractors. Therefore, a formulation of LBP in context of convolution operation is presented and used in the proposed CNN network. A non-trainable fixed set binary convolutional filters representing LBP features are combined with trainable convolution filters to approximate the response of the convolution layer. A CNN architecture guided by LBP features is used to classify the histopathological images.

Result:
The network is trained using BreKHis datasets. The use of a fixed set of LBP filters reduces the burden of CNN by minimizing training parameters by a factor of 9. This makes it suitable for the environment with fewer resources. The proposed network obtained 96.46% of maximum accuracy with 98.51% AUC and 97% F1-score.

Conclusion:
LBP based texture information plays a vital role in cancer image classification. A multi-channel LBP futures fusion is used in the CNN network. The experiment results propagate that the new structure of LBP-guided CNN requires fewer training parameters preserving the capability of the CNN network’s classification accuracy.
Analysis of Discrete Wavelet Transforms Variants for the Fusion of CT and MRI Images
Authors: Jain Nishant , Yadav Arvind , Kumar Sariya Yogesh , Balodi Arun 
Published: January 2022

Background:
Medical image fusion methods are applied to a wide assortment of medical fields, for example, computer-assisted diagnosis, telemedicine, radiation treatment, preoperative planning, and so forth. Computed Tomography (CT) is utilized to scan the bone structure, while Magnetic Resonance Imaging (MRI) is utilized to examine the soft tissues of the cerebrum. The fusion of the images obtained from the two modalities helps radiologists diagnose the abnormalities in the brain and localize the position of the abnormality concerning the bone.

Methods:
Multimodal medical image fusion procedure contributes to the decrease of information vulnerability and improves the clinical diagnosis exactness. The motive is to protect salient features from multiple source images to produce an upgraded fused image. The CT-MRI image fusion study made it conceivable to analyze the two modalities straightforwardly.
Several states of the art techniques are available for the fusion of CT & MRI images. The discrete wavelet transform (DWT) is one of the widely used transformation techniques for the fusion of images. However, the efficacy of utilization of the variants of wavelet filters for the decomposition of the images, which may improve the image fusion quality, has not been studied in detail. Therefore the objective of this study is to assess the utility of wavelet families for the fusion of CT and MRI images. In this paper investigation on the efficacy of 8 wavelet families (120 family members) on the visual quality of the fused CT & MRI image has been performed. Further, to strengthen the quality of the fused image, two quantitative performance evaluation parameters, namely classical and gradient information, have been calculated.

Results:
Experimental results demonstrate that amongst the 120 wavelet family members (8 wavelet families), db1, rbio1.1, and Haar wavelets have outperformed other wavelet family members in both qualitative and quantitative analysis.

Conclusion:
Quantitative and qualitative analysis shows that the fused image may help radiologists diagnose the abnormalities in the brain and localize the position of the abnormality concerning the bone more easily. For further improvement in the fused results, methods based on deep learning may be tested in the future.
Plant Growth-promoting and Bio-control Activity of Micrococcus luteus Strain AKAD 3-5 Isolated from the Soybean (Glycine max (L.) Merr.) Rhizosphere
Authors: Dubey Anamika , Kumar Ashwani , Khan Mohammed Latif , Payasi Devendra Kumar 
Published: January 2022

Background:
Applications of bioinoculants for improving crop productivity may be an eco-friendly alternative to chemical fertilizers. Rhizosphere or soil-inhabiting beneficial microbes can enhance plant growth and productivity through direct and indirect mechanisms, i.e., phosphate solubilization, nutrient acquisition, phytohormone production, etc.

Objective:
This study is based on the hypothesis that diseases resistant plants can act as a source of potential microbes that can have good plant growth-promoting traits and bio-control potential.

Methods:
In this study, we have isolated the rhizobacterial strains (AKAD 2-1, AKAD 2-10, AKAD 3-5, AKAD 3-9) from the rhizosphere of a disease-resistant variety of soybean (JS-20-34) (Glycine max (L.) Merr.). These bacterial strains were further screened for various plant growth-promoting traits (phosphate solubilization, indole acetic acid (IAA), ammonia, biofilm, HCN, Exopolysaccharide (EPS), and enzyme production activity (catalase, cellulase, and chitinase)).

Results:
Among four, only bacterial strain AKAD 3-5 has shown plant-growth-promoting and biocontrol (98%) activity against Fusarium oxysporum. Morphological, biochemical, and molecular characterization (16S rRNA) revealed that this rhizobacterial isolate AKAD 3-5 closely resembles Micrococcus luteus (Gene bank accession: MH304279).

Conclusion:
Here, we conclude that this strain can be utilized to promote soybean growth under varied soil stress conditions.
A Review on the Use of Nanomaterials in Agriculture: Benefits and
Associated Health Risks
Authors: Dubey Kashyap Kumar , Kumar Punit , Malik Sujata 
Published: January 2022

Background:
The present world population is about 7.9 billion and it is increasing
continuously. Thus, there is an urgent requirement to enhance the agricultural output
sustainably. Agricultural approaches such as the use of advanced agriculture methods, high
productivity varieties, and enhanced application of fertilizers and pesticides have significantly
increased food grain production but in an unsustainable way. Chemical-based conventional
fertilizers and pesticides have been found associated with environmental pollution and other
unwanted effects on the ecosystem, soil quality, soil microflora, etc. Nanomaterials may be
used to replace conventional fertilizers and pesticides in agriculture.

Objective:
The aim of this review is to provide information about the harmful effects of
chemical fertilizers and pesticides, and the use of nanomaterials in agriculture. Including this,
the health risks of nanomaterials are discussed.

Method:
This review article includes a survey of literature from different online sources (for
example, Web of Science, PubMed, and Google Scholar, etc.).

Results:
The improvement in agricultural output using chemical fertilizers and pesticides is
considered unsustainable as it is increasing the cost of production, affecting the soil quality,
disturbing nutrient availability in crops, and causing environmental pollution. Nanotechnology is
a potent innovative practice and nanomaterials may be used in agriculture as nanofertilizers,
nanopesticides, and nanosensors. Although these approaches have the potential to enhance
agricultural productivity in a sustainable way, nanomaterials are also assumed to exhibit potential
health risks to humans. Reports have indicated that nanomaterials have been found associated
with many systematic diseases such as cardiovascular diseases, neurotoxicity, and toxicity to the
reproductive system, etc.

Conclution:
It is well accepted that chemical fertilizers and pesticides in agriculture cause
environmental toxicity and affect ecosystem activity. Nanomaterials have the potential to
enhance agricultural output, but these are also associated with health risks. Thus, detailed
scientific studies must be conducted about the potential health risk of nanomaterials before
their commercial applications in agriculture.
Pharmacological and Nutritional Benefits of Flaxseed’s (Linum usitatissimum
Linn.) Biocomponents
Authors: Tarique Mohammad , Badruddeen  , Parveen Shahla , Ahsan Farogh , Khan Mohammad Irfan , Akhtar Juber , Khalid Mohammad , Gazanfer  , Muztaba Mohammad 
Published: January 2022

Abstract:
Linum usitatissimum (Linn.), Commonly known as flaxseed or flaxseed, belongs to the family Linaceae. Flaxseed is a crop of blue flowers that produce small, flat seeds of golden yellow to reddish-brown color. It is a native of the Mediterranean and West Asia. Due to its health benefits associated with the high content of linolenic acid (ALA), flaxseed has played a major role in diet and research. The ALA is an essential omega-3-fatty acid, and also due to its presence a major lignan, i.e. secoisolaricyrcinol diglucoside (SDG). There is also a wide range of uses of flaxseed oil in skin health, anticoagulants, anticancer, ulcer treatment, muscle growth, and weight loss. The nutritional composition of flaxseed is about 30% carbohydrate, 18% protein, and 39% fat. Flaxseed contains most carbohydrates in the form of fiber and contains more than 45% omega-3 fatty acids. It also contains dietary fibers, proteins and polyunsaturated fatty acids. All the ingredients possess different health benefits. Although plant resources are the key ingredient in drug discovery, the popularity of flaxseed always fascinate scientists, the number of articles giving information about the chemical components of flaxseed and its potential clinical use is very little. This review provides a systematic summary of the research completed over the past decade and provides an up-to-date summary of the various bioactive and outlines the relationship between the nutritional and pharmacological use of chemical ingredients and its flaxseed.
Antibiotics with Antiviral and Anti-Inflammatory Potential Against
Covid-19: A Review
Authors: Rahimi Hamid-Reza , Abadi Banafshe , Ilaghi Mehran , Shahsavani Yasamin , Faramarzpour Mahsa , Oghazian Mohammad Bagher 
Published: January 2022

Abstract:
In Covid-19 cases, elderly patients in long-term care facilities, children younger than
five years with moderate symptoms, and patients admitted to ICU or with comorbidities are at a
high risk of coinfection, as suggested by the evidence. Thus, in these patients, antibiotic therapy
based on empirical evidence is necessary. Finding appropriate antimicrobial agents, especially with
antiviral and anti-inflammatory properties, is a promising approach to target the virus and its complications,
hyper-inflammation, and microorganisms resulting in co-infection. Moreover, indiscriminate
use of antibiotics can be accompanied by Clostridioides difficile colitis, the emergence of resistant
microorganisms, and adverse drug reactions, particularly kidney damage and QT prolongation.
Therefore, rational administration of efficient antibiotics is an important issue. The main objective
of the present review is to provide a summary of antibiotics with possible antiviral activity
against SARS-CoV-2 and anti-immunomodulatory effects to guide scientists for further research.
Besides, the findings can help health professionals in the rational prescription of antibiotics in
Covid-19 patients with a high risk of co-infection.
Diet Supplementation with Madagascar Cockroach Flour (Gromphadorhina portentosa) Improved Malnourished Mice Metabolism and Ameliorated Liver Inflammatory Markers
Authors: Oliveira Janaína Ribeiro , Cota Junio , Carvalho Bruna Mara , de Oliveira Costa Theles , da Costa Diego Vicente , Santos Sérgio Henrique Sousa 
Published: January 2022

Background:
Malnutrition and accessible high-quality protein food sources are two of the world’s alimentary challenges. Edible insects are nowadays recognized as a possible functional food solution with lower environmental impacts and beneficial health effects. Objective: In this context, the aim of the present study is to evaluate Madagascar cockroach (Gromphadorhina portentosa) flour supplementation effects on a malnourished mice model, considering its effects on metabolism, adiposity, and inflammatory liver profiles.

Method:
Male Swiss mice are divided into five groups and fed with experimental diets for eight weeks, including a standard diet (ST) ad libitum, AIN93 ad libitum (AIN), insect flour-enriched AIN93 (AIN+IM), AIN-40% feed restriction (AIN-FR), and insect flour-enriched AIN-40% of feed restriction (AIN-FR+IM). The metabolic profiles, adipose tissue, biochemical parameters, and liver IL-6 and IL-10 expression are evaluated.

Results:
The main findings show a body weight and metabolism improvement followed by an increased recovery of the adipocyte area in the AIN-FR+IM group when compared to the AIN-FR malnourished group. Reduced hepatic IL-6 and increased IL-10 expression are also detected in the AIN-FR+IM group.

Conclusion:
The results show that insect flour supplementation enhances both body weight and adiposity gain/recovery. The results also show hepatic improvement of inflammatory markers.
Online Support and Intervention for Child Anxiety (OSI): Development and Usability Testing
Authors: Hill Claire , Reardon Tessa , Taylor Lucy , Creswell Cathy 
Published: January 2022

Background
Internet-based treatments for child anxiety may help to increase access to evidence-based therapies; however, user engagement, uptake, and adherence within routine clinical practice remain as challenges. Involving the intended end users in the development process through user-centered design and usability testing is crucial for maximizing user engagement and adoption of internet-based treatments, but so far this has been lacking for internet-based treatments for child anxiety.

Objective
The aim of this study is to develop an internet-based treatment for child anxiety through a process of user-centered design (phase 1) and usability testing (phase 2), based on an existing evidence-based, face-to-face, therapist-supported, parent-led cognitive behavioral therapy intervention. It is intended that the internet-based version of this treatment would consist of a parent website, case management system for clinicians, and mobile game app for children.

Methods
Parents, children, and clinicians who were familiar with the face-to-face version of the treatment were recruited from 2 National Health Service clinics. In phase 1, participants participated in 3 workshops to gain feedback on the overall concept, explore their wants and needs for the websites and game, generate ideas on how the treatment may look, and gain feedback on initial mock-ups of the websites and game. In phase 2, participants attended 3 individual usability testing sessions where they were presented with working prototypes of the website or game and asked to perform a series of tasks on the website (parents and clinicians) or play the game (children). The frequency and details on usability errors were recorded. Participants were asked for their feedback on the website and game using a standardized usability questionnaire and semistructured interviews. The websites and game were iterated after each round of usability testing in response to this feedback.

Results
In phase 1, participants approved the general concept and rated the initial mock-ups of the website and game positively. In phase 2, working prototypes were rated positively and usability errors declined across the iterations and were mainly cosmetic or minor issues relating to esthetic preference, with few issues regarding ability to navigate the website or technical issues affecting functionality. Feedback from the semistructured interviews further supported the positive response of participants to the website and game, and helped identify areas for improvement during the iteration process. The final iteration of the website and game are presented.

Conclusions
Taking an iterative approach to development through user-centered design and usability testing has resulted in an internet-based treatment for child anxiety (Online Support and Intervention for child anxiety) that appears to meet the needs and expectations of the intended users (parents, children, and clinicians) and is easy and enjoyable to use.
Las olas feministas, ¿una metáfora innecesaria?
Authors: Chaparro Amneris 
Published: January 2022

En este artículo ofrezco una exploración sobre la conformación de la metáfora de las olas feministas entendida como desplazamiento epistemológico. Después de un breve recuento histórico, doy cuenta de que, si bien la metáfora resulta útil paravisibilizar y sistematizar la lucha de las mujeres, un acercamiento más profundo da cuenta de sus limitaciones, omisiones y sesgos, así como de la falta de acuerdo sobre su temporalidad. Pese a lo anterior, sugiero que la metáfora es un recursoepistemológico valioso para pensar no sólo el pasado sino también el presente y el futuro de los feminismos.
Reducing visual analog scale (VAS) in circumcision patient by the additional of topical anesthesia agent in local anesthesia procedures
Authors: M. Fadel Dikaprio  , Romdhoni Muhammad Fadhol , Riyanto Refni Riyanto , Susiyadi  
Published: January 2022

Circumcision could be painful before, during, and after the surgery. The local anesthesia is often used in medical practice in order to reduce pain during circumcision. Topical anesthesia works by eliminating pain sensation after direct application on skin. This study aimed to investigate the effect of additional of topical anesthesia agent for circumcision on the visual analog scale (VAS). It was a cross sectional study using the data of medical records from a Circumcision Clinic (Rumah Sunatan) in Purwokerto, Central Java conducted from July 2019 to March 2020. As a result, there were 127 subjects (70.6%) belong to Mild Category VAS, while 26 subjects (14.4%) got Moderate, and 27 subjects (15.0%) fall under Severe Category. The application of topical anesthesia for circumcision could reduce the VAS value by 70.6 %.
Antimicrobial activity of Pycnarrhena cauliflora (Miers.) Diels. methanol extract
Authors: Eti Nurwening Sholikhah  , Maulina Diah  , Mustofa  , Masriani  , Susi Iravati  , Samekto Wibowo  
Published: January 2022

Pycnarrhena cauliflora (Miers.) Diels., local name sengkubak, is one of indigenous plants from West Kalimantan that has been used as natural flavor. Pycnorrhena cauliflora is one of species of Menispermaceae family which is rich in bisbenzylisoquinoline alkaloids. This alkaloids are known to have various biological activities including antiprotozoal, antiplasmodial, antifungal and antibacterial activities. This study aimed to investigate antimicrobial activity of the P. cauliflora (Miers.) Diels. methanolic extracts against gram-positive and gram-negative bacteria. The methanolic extract of P. cauliflora (Miers.) Diels., root, leaf and stem were prepared by maceration. The disk-diffusion method was then used to determine the antimicrobial activity of the extracts against Streptococcus pyogenes, S. mutants, Staphylococcus aureus, S. epidermidis, Salmonella typhi, Shigella flexneri, Pseudomonas aeruginosa and Escherichia coli after 18-24 h incubation at 37 oC. Amoxicillin was used as positive control for gram-positive bacteria and ciprofloxacin was used as gram-negative bacteria. The inhibition zones were then measured in mm. Analysis were conducted in duplicates. The results showed in general the methanolic extracts of P. cauliflora (Miers.) Diels. root (inhibition zone diameter= 10-23 mm) were more active than that leaf (0-15 mm) and stem (0-17 mm) extracts against gram-positive bacteria. The zone inhibition diameter of amoxicillin as positive control was 8-42 mm. In addition, the methanolic extracts of P. cauliflora (Miers.) Diels. root (12-17 mm) were also more active than that leaf (0-12 mm) and stem (0-12 mm) extracts against gram-negative bacteria. The zone inhibition diameter of ciprofloxacin as positive control was 33-36 mm. In conclusion, the methanolic extract of P. caulifloria (Miers.) Diels. root is the most extract active against both gram-positive and gram-negative bacteria. Further study will be focused to isolate active compounds in the methanolic extract of the root.
Remineralizer and controlled-release fertilizer increase Mimosa scabrella Benth. seedlings growth
Authors: Alexandre Alexandre Dal Forno Mastella , Mônica Moreno Gabira  , Letícia Siqueira Walter  , Rodrigo Condé Alves  , Chaiane Rodrigues Scheider  , Karen Koch Fernandes de Souza  , Dagma Kratz  , Alessandro Camargo Ângelo  
Published: January 2022

Contextualization: M. scabrella is a native tree species of the Brazilian Mixed Ombrophilous Forest, with a high ecological importance and economic potential.
Knowledge gap: There is a lack of information about the use of resources that favour the seedlings production of this species.
Purpose: This study aimed to determine the most appropriate doses of controlled-release fertilizer (CRF) combined with the addition of remineralizer for production of M. scabrella seedlings.
Methodology: Seedlings were produced using four doses of CRF (0, 4, 8, and 12 kg m-3) and four doses of remineralizer (0 %, 10 %, 20 %, and 30 %), in a 4 x 4 factorial scheme. At 180 days of seedling production, growth in height and stem diameter, shoot (SDB), root (RDB) and total biomass (TDB), and Dickson quality index (DQI) were evaluated.
Results and conclusions: The use of remineralizer provided an increase in density and water retention capacity of substrates, as well as a reduction of macroporosity and total porosity. Combined with doses of 4 and 8 kg m-3, CRF contributed to the increase of biomass and DQI. The addition of 10 % remineralizer, associated with 4.0 kg m-3 CRF, provides adequate growth to produce M. scabrella seedlings. Above this percentage of remineralizer and CRF dose, species growth rate is reduced.