bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strengths and challenges of the artificial intelligence in the assessment of dense breasts
Authors: Mansour Sahar , Soliman Somia , Kansakar Abisha , Marey Ahmed , Hunold Christiane , Hanafy Mennatallah Mohamed 
Published: July 2022

Objectives:
High breast density is a risk factor for breast cancer and overlapping of glandular tissue can mask lesions thus lowering mammographic sensitivity. Also, dense breasts are more vulnerable to increase recall rate and false-positive results. New generations of artificial intelligence (AI) have been introduced to the realm of mammography. We aimed to assess the strengths and challenges of adopting artificial intelligence in reading mammograms of dense breasts.

Methods:
This study included 6600 mammograms of dense patterns “c” and “d” and presented 4061 breast abnormalities. All the patients were subjected to full-field digital mammography, breast ultrasound, and their mammographic images were scanned by AI software (Lunit INSIGHT MMG).

Results:
Diagnostic indices of the sono-mammography: a sensitivity of 98.71%, a specificity of 88.04%, a positive-predictive value of 80.16%, a negative-predictive value of 99.29%, and a diagnostic accuracy of 91.5%. AI-aided mammograms presented sensitivity of 88.29%, a specificity of 96.34%, a positive-predictive value of 92.2%, a negative-predictive value of 94.4%, and a diagnostic accuracy of 94.5% in its ability to read dense mammograms

Conclusion:
Dense breasts scanned with AI showed a notable reduction of mammographic misdiagnosis. Knowledge of such software challenges would enhance its application as a decision support tool to mammography in the diagnosis of cancer.

Advances in knowledge:
Dense breast is challenging for radiologists and renders low sensitivity mammogram. Mammogram scanned by AI could be used to overcome such limitation, enhance the discrimination between benign and malignant breast abnormalities and the early detection of breast cancer.
A cross-sectional analysis in order to validate the translation of FSFI-6 to Bahasa Indonesia
Authors: Sesari Saras Serani , Elvira Sylvia Detri , Priyatini Tyas , Rahardjo Harrina Erlianti 
Published: July 2022

Background: Numerous tools have been developed to assess female sexual dysfunction. Several of them have also conducted validity tests. Female Sexual Function Index (FSFI) is one of these surveys that has been effectively translated into several different languages. The previous study on the translation and validation of the FSFI-6 questionnaire into Bahasa Indonesia used the original form (FSFI-19), which had many questions. Thus, this study was done to validate and translate a condensed version of the original questionnaire to make it more practicable for individuals to complete in a clinical context. Methods: FSFI-6 was translated into Bahasa Indonesia. Then the data were collected via questionnaires by 72 women in Rumah Sakit Cipto Mangunkusumo (RSCM or Mangunkusumo National Central General Hospital) during the data collection period (January 2018 until April 2018). The data obtained were processed for validity and reliability using the SPSS software program 20. The tests conducted on the data included a normality test, a validity test, descriptive analysis, and reliability testing. The r-value and the value of Cronbach’s Alpha were the parameters used to determine the validity and reliability of the questionnaire. Results: The r-value on each question in the translated FSFI-6 questionnaire was greater than 0.3, while the value of Cronbach's Alpha of the questionnaire FSFI-6 was greater than 0.6, equal to 0.831. Conclusions: The FSFI-6 questionnaire short version that has been translated into Bahasa Indonesia is valid and reliable.
A biopsychosocial approach to death, dying, and bereavement: a course on end-of-life education for medical students
Authors: Kripalani Simran , Joy Sandra , Raizada Shivani , Cerceo Elizabeth 
Published: July 2022

Background: Despite the inevitable nature of death and dying, the conversations surrounding this subject are still uncomfortable for many physicians and medical students. Methods: A six-week humanities-based course, “A Biopsychosocial Approach to Death, Dying, & Bereavement,” at Cooper Medical School of Rowan University, United States, which covers definitions of death and dying, the process of dying, ethical dilemmas, and new concepts of the grieving process. Through development of a curriculum using various academic and medical literature and resources, we sought to bring attention to the necessity of having a medical education curriculum on death and dying to prepare medical students for the difficult conversations and patient experiences that lie ahead of them. Qualitative data in the form of surveys and reflection papers submitted by students and quantitative data (Likert scores on course satisfaction) were collected and analyzed both pre- and post-course. Results: 90.7% (49/54) of the respondents answered that they agree or strongly agree with the statement that this selective course was useful in the student’s medical education experience. The top three qualitative themes brought up the most in reflection papers (n=50) were: the utility and instruction of the course (23 times), the importance of hospice and palliative care (23 times), and respecting patient autonomy (16 times). Conclusions: Medical students are often not prepared to cope with the realities of patient loss and of caring for the patient and their families throughout the dying process. We created this course to familiarize medical students with an aspect of the medical experience that is frequently neglected in traditional medical curricula. We learned that integrating such a course can help educate medical students facilitate important conversations, teach them to act with kindness and dignity in a physician-patient setting, and enhance their personal understanding of death and dying.
Recycling of platinum group metals from energy storage devices: a techno-economical business plan analysis
Authors: Spathariotis Stylianos , Sakkas Konstantinos Miltiadis , Polyzou Ekaterini , Yakoumis Iakovos 
Published: July 2022

Background: Energy storage devices utilise platinum group metals (PGMs) for their operation and exhibit an increasing adoption rate as green energy production means. Europe consumes the largest amount of PGMs worldwide (ca. 20% of the global demand), with the EU demand reaching ~71.5 t Pd, 78.7 t Pt in 2019; ~90% and 54% respectively for the production of (electro)catalysts. PGMs prices are on the rise, while these materials exhibit a risk of supply as their production in the EU is insignificant; South Africa and Russia produce approximately 84% of the global supply. Methods: PGMs recycling and reutilisation from End-of-Life products to new ones, can drastically facilitate the reduction of the supply/demand gap. Innovation business planning is needed to commercialise the recovered PGMs, which includes marketing and financial elements utilised from an innovation perspective. Results: SWOT (Strengths-Weaknesses-Opportunities-Threats) analysis is formed alongside a Business Model Canvas to define the Business Model and commercial added value. Conclusion: The Financial Plan illustrates that a PGMs recycling facility can be profitable upon the generated market volume and assists in determining the financial sustainability by calculating the Net Present Value (NPV), Initial Rate of Return (IRR) and the break-even point for an investment made.
bsnsing: A Decision Tree Induction Method Based on Recursive Optimal Boolean Rule Composition
Authors: Liu Yanchao 
Published: July 2022

This paper proposes a new mixed-integer programming (MIP) formulation to optimize split rule selection in the decision tree induction process and develops an efficient search algorithm that is able to solve practical instances of the MIP model faster than commercial solvers. The formulation is novel for it directly maximizes the Gini reduction, an effective split selection criterion that has never been modeled in a mathematical program for its nonconvexity. The proposed approach differs from other optimal classification tree models in that it does not attempt to optimize the whole tree; therefore, the flexibility of the recursive partitioning scheme is retained, and the optimization model is more amenable. The approach is implemented in an open-source R package named bsnsing. Benchmarking experiments on 75 open data sets suggest that bsnsing trees are the most capable of discriminating new cases compared with trees trained by other decision tree codes including the rpart, C50, party, and tree packages in R. Compared with other optimal decision tree packages, including DL8.5, OSDT, GOSDT, and indirectly more, bsnsing stands out in its training speed, ease of use, and broader applicability without losing in prediction accuracy. History: Accepted by RamRamesh, Area Editor for Data Science & Machine Learning. Funding: This work was supported by the National Science Foundation Division of Civil, MechanicalandManufacturing Innovation [Grant 1944068]. Supplemental Material: Data are available at https://doi.org/10.1287/ijoc.2022.1225 .
Dengue, Zika, and Chikungunya viral circulation and hospitalization rates in Brazil from 2014 to 2019: An ecological study
Authors: Pescarini Julia M. , Rodrigues Moreno , Paixão Enny S. , Cardim Luciana , Brito Carlos A. A. de , Costa Maria da Conceição N. , Santos Andreia C. , Smeeth Liam , Teixeira Maria da Glória , Souza André P. F. de , Barreto Mauricio L. , Brickley Elizabeth B. 
Published: July 2022

Background
In addition to their direct pathogenic effects, arthropod-borne (arboviruses) have been hypothesized to indirectly contribute to hospitalizations and death through decompensation of pre-existing comorbidities. Using nationwide data routinely collected from 1 January 2014 to 31 December 2019 in Brazil, we investigated whether local increases in arbovirus notifications were associated with excess hospitalization.

Methods
We estimated the relative risks for the association between municipality- and state-level increases in arboviral case notifications and age-standardized hospitalization rates (i.e., classified as direct or indirect based on ICD-10 codes) using Bayesian multilevel models with random effects accounting for temporal and geographic correlations. For municipality-level analyses, we excluded municipalities with <200 notifications of a given arbovirus and further adjusted the models for the local Gini Index, Human Development Index, and Family Healthcare Strategy (Estratégia de Saúde da Família) coverage. Models for dengue, Zika, and chikungunya were performed separately.

Results
From 2014 to 2019, Brazil registered 7,566,330 confirmed dengue cases, 159,029 confirmed ZIKV cases, and 433,887 confirmed CHIKV cases. Dengue notifications have an endemic and seasonal pattern, with cases present in 5334 of the 5570 (95.8%) Brazilian municipalities and most (69.5%) registered between February and May. Chikungunya notifications followed a similar seasonal pattern to DENV but with a smaller incidence and were restricted to 4390 (78.8%) municipalities. ZIKV was only notified in 2581 (46.3%) municipalities. Increases in dengue and chikungunya notifications were associated with small increases in age-standardized arbovirus-related hospitalizations, but no consistent association was found with all-cause or other specific indirect causes of hospitalization. Zika was associated to increases in hospitalizations by neurological diseases.

Conclusions
Although we found no clear association between increased incidence of the three arboviruses and excess risks of all-cause or indirect hospitalizations at the municipality- and state-levels, follow-up investigations at the individual-level are warranted to define any potential role of acute arbovirus infection in exacerbating risks of hospitalization from underlying conditions.
Presence of antiphospholipid antibodies is associated with increased implantation failure following in vitro fertilization technique and embryo transfer: A systematic review and meta-analysis
Authors: Papadimitriou Eirini , Boutzios Georgios , Mathioudakis Alexander G. , Vlahos Nikos F. , Vlachoyiannopoulos Panayiotis , Mastorakos George 
Published: July 2022

Purpose
A systematic review and meta-analysis was conducted comparing the presence of anti-phospholipid (anti-PL) antibodies between women of reproductive age, without diagnosis of antiphospholipid syndrome, who experienced at least two implantation failures following in vitro fertilization and embryo transfer (IVF-ET), and either women who had a successful implantation after IVF-ET or women with at least one successful spontaneous pregnancy or unselected healthy fertile women with no history of IVF-ET.

Methods
Systematic search of the literature and meta-analysis of the relevant studies studying presence of antiphospholipid antibodies in women experiencing at least two implantation failures in IVF-ET as compared to either women who had a successful implantation after IVF-ET or/and women with at least one successful spontaneous pregnancy or unselected healthy fertile women with no history of IVF-ET. Six hundred ninety-four published reports were retrieved; 17 of them fulfilled the inclusion criteria set.

Results
Presence of either any type of anti-phospholipid or anticardiolipin antibodies or lupus-anticoagulant in women experiencing at least two implantation failures in IVF-ET was associated with increased implantation failure compared to women who had a successful implantation after IVF-ET (relative risk, RR: 3.06, 5.06 and 5.81, respectively). Presence of either anticardiolipin or lupus-anticoagulant or anti-beta2 glycoprotein-I or anti-phosphatidylserine antibodies in women experiencing at least two implantation failures in IVF-EΤ was associated with increased implantation failure compared to unselected healthy fertile women with no history of IVF-ET (RR:13.92, 6.37, 15.04 and 164.58, respectively).

Conclusion
The prevalence of antiphospholipid antibodies, particularly that of anti-beta2 glycoprotein-I and anti-phosphatidylserine antibodies, in women experiencing at least two implantation failures in IVF-ET without diagnosis of antiphospholipid syndrome is significantly greater than either in women who had a successful implantation after IVF-ET or women with at least one successful spontaneous pregnancy or unselected healthy fertile women with no history of IVF-ET.

Trial registration number
PROSPERO ID: CRD42018081458
Incidence and predictors of death from COVID-19 among patients admitted to treatment center of Wollega University Referral Hospital, Western Ethiopia: A retrospective cohort study
Authors: Tolossa Tadesse , Wakuma Bizuneh , Ayala Diriba , Seyoum Dejene , Fetensa Getahun , Getahun Ayantu , Mulisa Diriba , Atomssa Emiru Merdassa , Tsegaye Reta , Shibiru Tesfaye , Turi Ebisa , Bayisa Lami , Fekadu Ginenus , Bekele Balay , Feyisa Ilili 
Published: July 2022

Introduction
Currently, COVID-19 contributes to mortality and morbidity in developed as well as in developing countries since December 2019. However, there is scarcity of evidence regarding the incidence and predictors of death among patients admitted with COVID-19 in developing country including Ethiopia, where the numbers of deaths are under-reported. Hence, this study aimed to assess the incidence and predictors of death among patients admitted with COVID-19 in Wollega University Referral Hospital (WURH), western Ethiopia.

Methods
An institution based retrospective cohort study design was conducted among 318 patients admitted with COVID-19 in WURH treatment center. Patients who were tested positive for COVID-19 by using rRT-PCR test and admitted with the diagnosis of severe COVID-19 cases from September 30, 2020 to June 10, 2021 were a source population. Epidata version 3.2 was used for data entry, and STATA version 14 for analysis. A Cox proportional hazard regression analysis was used to determine factors associated with mortality from COVID-19. Multivariable Cox regression model with 95% CI and Adjusted Hazard Ratio (AHR) was used to identify a significant predictor of mortality from COVID-19 at p-value < 0.05.

Results
A total of 318 patients were included in final analysis with mean age of 44 (SD±16.7) years and about two third (67.9%) were males. More than half (55.7%) of patients had no comorbidity on admission. The majority, 259 (81.45%) of patients recovered from COVID-19 and 267 (84%) of patients were censored at the end of follow up. The incidence rate of mortality was 14.1 per/1000 (95%CI: 10.7, 18.5) person days observation. Age ≥ 59 years (AHR: 5.76, 95%CI: 2.58, 12.84), low oxygen saturation (AHR: 2.34, 95% CI: (2.34, 4.17), and delayed presentation (AHR: 5.60, 95%CI: 2.97, 10.56) were independent predictors of mortality among COVID-19 patients.

Conclusion
The mortality rate of COVID-19 pandemic was high in the study area, and most of death was happened during the first 10 days. Being old age, low oxygen saturation and delayed presentation were factors which predict mortality due to COVID-19. Hence, strengthening the health care delivery system to satisfy the need of the patients should get due attention to reduce the incidence of mortality from COVID-19 cases.
Disease progression role as well as the diagnostic and prognostic value of microRNA-21 in patients with cervical cancer: A systematic review and meta-analysis
Authors: Gebrie Alemu 
Published: July 2022

IntroductionCervical cancer is the fourth commonest and the fourth leading cause of cancer death in females globally. The upregulated expression of microRNA-21 in cervical cancer has been investigated in numerous studies, yet given the inconsistency on some of the findings, a systematic review and meta-analysis is needed. Therefore, the aim of this systematic review and meta-analysis is to investigate the role in disease progression as well as the diagnostic and prognostic value of microRNA-21 in patients with cervical cancer.MethodsLiterature search was carried out through visiting several electronic databases including PubMed/MEDLINE/ PubMed Central, Web of Science, Embase, WorldCat, DOAJ, ScienceDirect, and Google Scholar. After extraction, data analysis was carried out using Rev-Man 5.3, STATA 15.0 and Meta-disk 1.4. I2 and meta-bias statistics assessed heterogeneity and publication bias of the included studies, respectively. The area under summary receiver operating characteristic curve and other diagnostic indexes were used to estimate diagnostic accuracy.ResultA total of 53 studies were included for this systematic review and meta-analysis. This study summarized that microRNA-21 targets the expression of numerous genes that regulate their subsequent downstream signaling pathways which promote cervical carcinogenesis. The targets addressed in this study included TNF-α, CCL20, PTEN RasA1, TIMP3, PDCD-4, TPM-1, FASL, BTG-2, GAS-5, and VHL. In addition, the meta-analysis of reports from 6 eligible studies has demonstrated that the overall area under the curve (AUC) of summary receiver operating characteristic (SROC) of microRNA-21 as a diagnostic accuracy index for cervical cancer was 0.80 (95% CI: 0.75, 0.86). In addition, evidence from studies revealed that upregulated microRNA-21 led to worsening progression and poor prognosis in cervical cancer patients.ConclusionmicroRNA-21 is an oncogenic microRNA molecule playing a key role in the development and progression of cervical malignancy. It has good diagnostic accuracy in the diagnosis of cervical cancer. In addition, the upregulation of microRNA-21 could predict a worse outcome in terms of prognosis in cervical cancer patients.
Primary stability of multi-hole cups compared to plate osteosynthesis in osteoporotic anterior column and posterior hemi-transverse acetabular fractures—A biomechanical comparison
Authors: Höch Andreas , Reise Rebekka , Pieroh Philipp , Heyde Christoph-Eckhard , Fakler Johannes Karl Maria , Schleifenbaum Stefan 
Published: July 2022

Introduction
Acetabular fractures pose high demands on the surgeon and in the case of osteosynthetic treatment, anatomical reconstruction has the highest priority to achieve a good outcome. However, especially in older patients with poor bone quality, even anatomical reconstruction is no guarantee for a good clinical outcome and may nevertheless end in early osteoarthritis. Primary arthroplasty therefore has an increasing importance in the treatment of these patients. The aim of this study was to biomechanically compare fracture gap displacement and failure load as an assessment measure of the primary stability of conventional plate osteosynthesis with the treatment using a sole multi-hole cup for acetabular fractures.

Methods
Six hemi-pelvises each with anterior column and posterior hemi-transverse (ACPHT) fracture were treated with either plate osteosynthesis or a multi-hole cup. The tests were carried out in a standardised test set-up with cyclic loading in various stages between 150 N and 2500 N. The fracture gap displacement was recorded with optical 3D measuring and the failure load was determined after the cyclic measurement.

Results
With increasing force, the fracture gap displacement increased in both procedures. In each group there was one treatment which failed at the cyclic loading test and a bone fragment was broken out. The primary stability in arthroplasty was comparable to that of the standard osteosynthesis.

Conclusions
The results found seem promising that the primary arthroplasty with a sole multi-hole cup and corresponding screw fixation achieves an initial stability comparable to osteosynthesis for typical ACPHT fractures. However, further clinical studies are needed to prove that the cups heal solidly into the bone.
Go south! – The establishment of Hungarian–Ethiopian diplomatic relations in 1959-1960
Authors: Marsai Viktor 
Published: July 2022

Abstract
In the mid-1950s, the Hungarian Ministry of Foreign Affairs made an effort to break free of the isolation brought about by the military defeat and communist takeover after WWII. One of the main priorities of Hungarian foreign policy was the developing world, including Africa. Although the revolution and subsequent reprisals of 1956 temporarily halted the opening up, at the end of the decade Hungary launched a new diplomatic offensive. Ethiopia, which symbolized African independence and power, was among the main targets. In spite of the setbacks and challenges, and thanks to the determination of Hungarian diplomats, Hungarian-Ethiopian relations were normalized in 1959–60. This paper examines this process by analyzing documents from the Hungarian National Archive and explains why establishing diplomatic connections proved valuable to both parties.
On a more accurate half-discrete Hilbert-type inequality involving hyperbolic functions
Authors: You Minghui , Sun Xia , Fan Xiansheng 
Published: July 2022

Abstract
In this work, by the introduction of a new kernel function composed of exponent functions with several parameters, and using the method of weight coefficient, Hermite-Hadamard’s inequality, and some other techniques of real analysis, a more accurate half-discrete Hilbert-type inequality including both the homogeneous and non-homogeneous cases is established. Furthermore, by introducing the Bernoulli number and the rational fraction expansion of tangent function, some special and interesting Hilbert-type inequalities and their equivalent hardy-type inequalities are presented at the end of the paper.