bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boric acid thermal etching graphite felt as a high-performance electrode for iron-chromium redox flow battery
Authors: Li Zhen , Guo Lili , Chen Na , Su Yang , Wang Xiaomin 
Published: January 2022

Abstract
Iron-chromium redox flow battery (ICRFB) is a secondary battery capable of deep charge and discharge. It is a novel electrochemistric equipment for energy storage. ICRFB has around wide concern as it possesses advanced characteristics such as high energy, long cycle life, and environmental friendly. Graphite felt is a common electrode material for ICRFB because of its high temperature resistance, corrosion resistance, infinite specific surface area, and admirable electroconductibility. However, poor hydrophilicity and electrochemical activity lead to the graphite felt to be modified to be better applied in ICRFB. To improve the electrochemical activity of graphite felt, the PAN-based graphite felt was activated by boric acid thermal etching, and tested with SEM analysis, electrochemical analysis, and charge-discharge test. The results showed that the electrochemical activity and reversibility of boric acid thermal etching graphite felt impregnated with 25% boric acid solution were significantly improved after thermal treatment at 500 °C for 5 h. The Energy Efficiency of boric acid thermal etching graphite felt impregnated with 25% boric acid solution in ICRFB could reach more than 85%, which was about 9.5% higher than that of ICRFB with untreated graphite felt (1#) as electrode.
Muscle thickness assessment of the forearm via ultrasonography: is experience level important?
Authors: Wong Vickie , Song Jun Seob , Abe Takashi , Spitz Robert W , Yamada Yujiro , Bell Zachary W , Kataoka Ryo , Kang Minsoo , Loenneke Jeremy P 
Published: January 2022

Abstract
It is suggested that experience is needed in order to capture valid estimates of muscle size with ultrasound. However, it is unknown whether there is a large degree of skill needed to analyze the images once they are captured. Objective. To determine if less experienced raters could accurately analyze ultrasound images of the forearm by comparing their estimates with those of a very experienced ultrasonographer (criterion). Approach. 50 muscle thickness images were captured by one experienced ultrasonographer (also Rater 1). Those images were saved and were then measured by four raters with different levels of experience. The rater who captured the images was very experienced (criterion), the second rater was also experienced and provided 5 minutes of instruction for Rater 3 (minimal experience) and Rater 4 (no experience). Test-retest reliability was also determined for Rater 3 and 4. Main Results. The average muscle thickness value for the criterion was 3.73 cm. The constant error for Rater 2, 3, and 4 was −0.003 (0.02) cm (p = 0.362), −0.07 (0.04) cm (p < 0.001), and 0.02 (0.09) cm (p = 0.132), respectively. The SD for Rater 4 was greater, resulting in wider limits of agreement compared to Rater 2 and 3. Absolute error was 0.01 cm for Rater 2, whilst it was 0.07 cm and 0.03 cm for the two inexperienced raters (Rater 3 and 4). The error for Rater 3 was systematic and post-hoc assessment found that this rater was using a different border than the other three raters (but consistent across time). For the test-retest reliability, the minimal difference for Rater 3 was 0.08 cm (relative minimal difference of 2%) and 0.17 cm (relative minimal difference of 4%) for Rater 4. Significance. Less experienced raters were able to accurately and reliably analyze already captured muscle thickness images of the forearm with low absolute errors.
Emerging Mosquito Resistance to Piperonyl Butoxide-Synergized Pyrethroid Insecticide and Its Mechanism
Authors: Zhou Guofa , Li Yiji , Jeang Brook , Wang Xiaoming , Cummings Robert F , Zhong Daibin , Yan Guiyun 
Published: January 2022

AbstractPiperonyl butoxide (PBO)-synergized pyrethroid products are widely available for the control of pyrethroid-resistant mosquitoes. To date, no study has examined mosquito resistance after pre-exposure to PBO and subsequent enzymatic activity when exposed to PBO-synergized insecticides. We used Culex quinquefasciatus Say (Diptera: Culicidae), an important vector of arboviruses and lymphatic filariasis, as a model to examine the insecticide resistance mechanisms of mosquitoes to PBO-synergized pyrethroid using modified World Health Organization tube bioassays and biochemical analysis of metabolic enzyme expressions pre- and post-PBO exposure. Mosquito eggs and larvae were collected from three cities in Orange County in July 2020 and reared in insectary, and F0 adults were used in this study. A JHB susceptible strain was used as a control. Mosquito mortalities and metabolic enzyme expressions were examined in mosquitoes with/without pre-exposure to different PBO concentrations and exposure durations. Except for malathion, wild strain Cx quinquefasciatus mosquitoes were resistant to all insecticides tested, including PBO-synergized pyrethroids (mortality range 3.7 ± 4.7% to 66.7 ± 7.7%). Wild strain mosquitoes had elevated levels of carboxylesterase (COE, 3.8-fold) and monooxygenase (P450, 2.1-fold) but not glutathione S-transferase (GST) compared to susceptible mosquitoes. When wild strain mosquitoes were pre-exposed to 4% PBO, the 50% lethal concentration of deltamethrin was reduced from 0.22% to 0.10%, compared to 0.02% for a susceptible strain. The knockdown resistance gene mutation (L1014F) rate was 62% in wild strain mosquitoes. PBO pre-exposure suppressed P450 enzyme expression levels by 25~34% and GST by 11%, but had no impact on COE enzyme expression. Even with an optimal PBO concentration (7%) and exposure duration (3h), wild strain mosquitoes had significantly higher P450 enzyme expression levels after PBO exposure compared to the susceptible laboratory strain. These results further demonstrate other studies that PBO alone may not be enough to control highly pyrethroid-resistant mosquitoes due to multiple resistance mechanisms. Mosquito resistance to PBO-synergized insecticide should be closely monitored through a routine resistance management program for effective control of mosquitoes and the pathogens they transmit.
Wound Closure with Transcutaneous Absorbable Polyglactin Sutures after Hidradenitis Suppurativa Excision
Authors: Drogt Carolyn , Hanwright Philip , Ha Michael , Ngaage Ledibabari M. , Lin Mary , Ge Shealinna , Wu Yinglun , Silverman Ronald P. , Rasko Yvonne M. 
Published: January 2022

ABSTRACT

OBJECTIVE
Wide surgical excision is the standard treatment for severe hidradenitis suppurativa (HS). Because of the nature of HS, these wounds are often nonsterile, located in moist intertriginous regions, and closed under tension, increasing the risk for surgical site complications. Although uncommon, absorbable sutures may confer benefits over nonabsorbable material for skin closure. Accordingly, the authors evaluated the use of absorbable, braided, transcutaneous polyglactin sutures after wide surgical excision of HS.

METHODS
The authors performed a retrospective chart review for all consecutive patients who underwent wide surgical excision of HS at a tertiary university hospital between January 2009 and March 2020.

RESULTS
Sixty consecutive patients with 174 operative sites were included in the study. The surgical site complication rate was 17.8%. Postoperative complications included wound dehiscence (n = 18), surgical site infection (n = 2), and scar contracture (n = 1). Sutures were removed from 12 (6.9%) operative sites. Factors influencing complications were Hurley grade and area of excision. Complications did not differ significantly among disease locations (P = .6417).

CONCLUSIONS
The results support the growing evidence that absorbable sutures are an appropriate option after wide surgical excision of HS.
Melanoma with genetic alterations beyond the BRAF V600 mutation: management and new insights
Authors: Awada Gil , Neyns Bart 
Published: January 2022

Purpose of review
Molecular-targeted therapy with BRAF-/MEK-inhibitors has shown impressive activity in patients with advanced BRAF

V600
mutant melanoma. In this review, we aim to summarize recent data and possible future therapeutic strategies involving small-molecule molecular-targeted therapies for advanced BRAF

V600
wild-type melanoma.

Recent findings
In patients with NRAS

Q61
mutant melanoma, downstream MEK-inhibition has shown some albeit low activity. MEK-inhibitors combined with novel RAF dimer inhibitors, such as belvarafenib, or with CDK4/6-inhibitors have promising activity in NRAS mutant melanoma in early-phase trials. In patients with non-V600 BRAF mutant melanoma, MEK-inhibition with or without BRAF-inhibition appears to be effective, although large-scale prospective trials are lacking. As non-V600 BRAF mutants signal as dimers, novel RAF dimer inhibitors are also under investigation in this setting. MEK-inhibition is under investigation in NF1 mutant melanoma. Finally, in patients with BRAF/NRAS/NF1 wild-type melanoma, imatinib or nilotinib can be effective in cKIT mutant melanoma. Despite preclinical data suggesting synergistic activity, the combination of the MEK-inhibitor cobimetinib with the immune checkpoint inhibitor atezolizumab was not superior to the immune checkpoint inhibitor pembrolizumab.

Summary
As of today, no molecular-targeted therapies have shown to improve survival in patients with advanced BRAF

V600
wild-type melanoma. Combinatorial strategies, involving MEK-inhibitors, RAF dimer inhibitors and CDK4/6-inhibitors, are currently under investigation and have promising activity in advanced BRAF

V600
wild-type melanoma.
ACUTE RETINAL PIGMENT EPITHELIITIS: ASSOCIATION WITH ACUTE COXSACKIE A VIRUS INFECTION
Authors: Colucciello Michael 
Published: January 2022

Purpose:
The purpose of this study was to describe the occurrence of acute retinal pigment epitheliitis in association with serologic evidence of acute Coxsackie A virus infection.

Methods:
This study is a case report.

Results:
A 37-year-old man noted an acute onset of paracentral scotomas in his right eye correlating with stippled retinal pigment epithelial pigment alterations with whitish halos surrounding the fovea. Spectral domain optical coherence tomography revealed scattered distinct retinal pigment epithelial elevations in the paracentral macular region arranged in an annular fashion, with associated alterations in the interdigitation and ellipsoid zone layers anterior to the retinal pigment epithelial, characteristic of acute retinal pigment E. Suspicion of acute Coxsackie A virus in the patient because of the presence of simultaneous viral exanthematous illness in the patient's 1-year-old son prompted serologic testing for Coxsackie virus. Titers showed strongly positive IgM (“early”) antibody for several Coxsackievirus A serotypes, including A16 (most commonly associated with hand-foot-mouth disease). Spontaneous regression of the anatomical and clinical findings occurred over the next month, with complete resolution noted 16 months later.

Conclusion:
This is the first documented case of acute retinal pigment epitheliitis associated with evidence of acute Coxsackie A virus infection. Corroboration with serology in future cases would add to evidence that acute retinal pigment epitheliitis is part of the apparently expanding spectrum of recognized “Coxsackie retinopathies.”
SPONTANEOUS CLOSURE OF MYOPIC MACULAR HOLE TWICE WITHOUT POSTERIOR VITREOUS DETACHMENT
Authors: Chen Fang-Ting 
Published: January 2022

Purpose:
To present a case of a myopic macular hole that spontaneously closed twice in the presence of a broadly adherent posterior hyaloid membrane.

Methods:
Case report.

Results:
A 49-year-old man with high myopia and pseudophakia had a full-thickness macular hole in the left eye. The hole spontaneously closed in all retinal layers before the elective surgery, but the macular hole recurred one month later. The hole started sealing again spontaneously after one month, leaving a defect in the outer retinal layers. Four months later, the outer layer defect sealed and a lamellar macular hole developed. Throughout the course, the posterior hyaloid membrane remained parallel to the macular surface. The macular morphology and the patient's vision remained stationary at the 2-year follow-up.

Conclusion:
This case demonstrated that myopic macular holes can form and seal repeatedly with a broadly adherent posterior hyaloid membrane. Although bridging phenomenon was the common sign indicating the initiation of the two hole closures, different patterns of tissue regeneration ensued.
Efficacy and Safety of High‐dose Cholecalciferol in Patients With Inflammatory Bowel Disease Receiving Infliximab
Authors: Gordon Rebecca J. , Wells Reeder , Johansen Camille , Liu Shanshan , Dahlberg Suzanne E. , Snapper Scott B. , Rufo Paul A. 
Published: January 2022

ABSTRACTObjective:Vitamin D deficiency is prevalent in patients with inflammatory bowel disease (IBD). The goal of this study was to assess the efficacy and safety of high‐dose, interval cholecalciferol administration in patients with IBD receiving infliximab.Methods:This prospective, longitudinal, open‐label study enrolled pediatric and young adult patients with IBD and vitamin D deficiency. Subjects received 50,000 IU every 4 to 5 weeks (n = 11) or 100,000 IU every 6 to 8 weeks (n = 32) of oral cholecalciferol for 1 year. Dosing was directly observed and administered in conjunction with infliximab infusions. The primary endpoint was vitamin D sufficiency, defined as a 25‐hydroxy‐vitamin D (25‐OHD) level ≥30 ng/mL.Results:Forty‐three participants constituted the primary analysis population. 25‐OHD levels reached steady‐state after the third dose, and mean increases in 25‐OHD levels were 8 vs. 4.5 ng/mL in the 100,000 IU vs. 50,000 IU treatment groups, respectively. Only 43.8% of patients receiving 100,000 IU and 18.2% of patients receiving 50,000 IU achieved sufficiency. There was no difference in the 25‐OHD level responsiveness in patients with Crohn disease versus those with ulcerative colitis (P = 0.72). There was no correlation between 25‐OHD levels and clinical disease activity in patients with Crohn disease (P = 0.85) or ulcerative colitis (P = 0.24).Conclusions:Supplementation with cholecalciferol was well‐tolerated and direct observation is a promising paradigm for ensuring compliance with therapy. Patients with IBD, however, appear to require high doses of cholecalciferol, with less than half of patients (37% overall) achieving vitamin D sufficiency. Additional studies are necessary to determine the optimal treatment regimens.
Does IT matter for work meaningfulness?: Exploring the mediating role of job crafting
Authors: Xu Mengxi , Wang Wei , Ou Carol Xiaojuan , Song Baoxiang 
Published: January 2022

PurposeThis study aims to investigate how technology characteristics facilitate employees' work meaningfulness through job crafting.Design/methodology/approachThis study applies the survey method and collects data from 357 Chinese participants with the experience of using information technology (IT) at work.FindingsTechnology characteristics (i.e. technology reconfigurability and technology customization) enable employees to craft their jobs, contributing to work meaningfulness.Research limitations/implicationsIt remains to be seen whether the findings can be generalized to other cultural contexts. This study justifies the positive effects of IT but does not take into consideration the IT factors that might thwart job crafting.Practical implicationsIT is not merely a work tool. It is a contextual component strongly conducive to cultivating work meaningfulness. However, IT itself cannot directly lead to work meaningfulness. Instead, its contribution to job crafting matters.Originality/valueThe literature on the downstream impact of IT has yet to consider the value of IT for job crafting and work meaningfulness. This study verifies that job crafting is the linking mechanism between IT and work meaningfulness.
Idea paper: Monitoring and databasing nonnative species to manage establishment debt in aquatic ecosystems
Authors: Saito Takumi 
Published: January 2022

AbstractIn the era of globalization, biological invasions are one of the most serious social issues. Thus, managing its impact is an urgent task. It is essential to control nonnative species before they become established. However, it is insufficient to address establishment debt, which occurs when a nonnative species has been introduced into an area but has not yet been established in the wild. In particular, unintentionally introduced or contaminated organisms of the aquatic ornamental pet trade are referred to as “hitchhikers” and have not received much attention in the context of establishment debt. To understand the nature of establishment debt, including that of aquatic hitchhikers, I propose the monitoring of nonnative species inhabiting artificial isolated waters, such as indoor aquariums, and the construction of a database using environmental DNA metabarcoding. This idea would be an effective nonregulatory management approach when implemented broadly, at the country level. Furthermore, implementation of this strategy in combination with border biosecurity and field monitoring may promote accurate prioritization, rapid species identification, and effective invasion pathway assessment.
Hot air‐assisted radio frequency drying of apricots: Mathematical modeling study for process design
Authors: Topcam Huseyin , Gogus Fahrettin , Ozbek Hatice Neval , Elik Aysel , Yanik Derya Kocak , Dalgic Ali Coskun , Erdogdu Ferruh 
Published: January 2022

AbstractConventional hot air and solar energy processes have been used for apricot. These processes had adverse effects on the quality due to the longer process times, and this indicates the need for an innovative approach. Radio frequency (RF) processing has innovation potential for drying with its volumetric heating feature, but an optimal process should be designed for process efficiency in industrial‐scale applications. Therefore, the objective of this study was to confirm the RF process for industrial‐scale apricot drying. For this purpose, a mathematical model was developed to predict temperature and moisture content change of apricots during drying, and experimental validation study was carried out. For the RF drying process, pre‐dried apricots (0.58–0.75 kg water/kg dry matter, db) by solar energy were used. The purpose was to start the RF process at a suitable moisture content level as this process was not feasible to apply directly due to the high initial moisture content of apricots (up to 4 kg water/kg dry matter, db). RF drying experiments were carried out in a 10 kW hot air‐assisted (50–60°C) staggered through electrode system. Optimum electrode gap was 81 mm with 2500 V potential of the charged electrode. Final moisture content of the dried apricots was 0.25–0.33 kg water/kg dry matter (db). Following the model validation for temperature and moisture content change, industrial‐scale apricot drying scenarios were demonstrated to confirm the RF process for feasibility and process design.Practical ApplicationA comprehensive mathematical model was developed for radio frequency (RF) drying of apricots. This model was experimentally validated with respect to the temperature and moisture content change. Various process design studies were carried out for an industrial‐scale apricot drying process to confirm the process feasibility. With this background, the results of this study can be directly used in an industrial drying for an optimal process design and energy efficiency.
Social trust, corporate governance, and stock price crash risk: Evidence from China
Authors: Su Kun , Song Victor 
Published: January 2022

AbstractWe empirically examine the relationship between social trust and stock price crash risk using data for Chinese listed companies from 2003 to 2016. Social trust reduces concealing of bad news by managers, thereby lowering stock price crash risk. We also explore the interaction between social trust and other corporate governance mechanisms, including incentive and monitoring mechanisms, and its effect on stock price crash risk. We find that the effect of social trust is more pronounced in firms with little managerial shareholding and a small proportion of independent directors, indicating that social trust strengthens corporate governance when other internal mechanisms are weak.
Assessing donor‐recipient size metrics for heart transplant outcomes: UNOS database analysis
Authors: Bauer Tyler M. , Weber Matthew P. , O'Malley Thomas J. , Moncure Henry , Pirlamarla Preethi R. , Shah Mahek K. , Alvarez Rene J. , Morris Rohinton J. , Entwistle John W. , Massey Howard Todd , Tchantchaleishvili Vakhtang 
Published: January 2022

AbstractStudyThere is no widely accepted donor to recipient size‐match metric to predict outcomes in cardiac transplant. The predictive ability of size‐match metrics has not been studied when recipients are stratified by heart failure etiology. We sought to assess the performance of commonly used size metrics to predict survival after heart transplant, accounting for restrictive versus non‐restrictive pathology.MethodsThe UNOS registry was queried from 2000 to 2017 for all primary isolated heart transplants. Donor‐recipient ratios were calculated for commonly used size metrics and their association with survival was assessed using continuous, nonlinear analysis.Results29 817 patients were identified. Height (P < .001), predicted heart mass (PHM) (P = .003), ideal body weight (IBW) (P < .001) and body mass index (BMI) (P = .003) ratios were significantly associated with survival, while weight and body surface area (BSA) ratios were not. When stratified, only BMI ratio retained significance for both restrictive (P = .051) and non‐restrictive (P = .003) subsets. Recipients with restrictive etiology had increased risk of mortality with both a lower and higher BMI ratio.ConclusionsWhile many metrics show association with survival in the non‐restrictive subset, BMI is the only metric that retains significance in the restrictive subset. Recipients with restrictive and non‐restrictive etiologies of heart failure tolerate size mismatch differently.
Peppermint oil effects on the gut microbiome in children with functional abdominal pain
Authors: Thapa Santosh , Luna Ruth Ann , Chumpitazi Bruno P. , Oezguen Numan , Abdel‐Rahman Susan M. , Garg Uttam , Musaad Salma , Versalovic James , Kearns Gregory L. , Shulman Robert J. 
Published: January 2022

AbstractPeppermint oil (PMO) is effective in the treatment of functional abdominal pain disorders, but its mechanism of action is unclear. Evidence suggests PMO has microbicidal activity. We investigated the effect of three different doses of PMO on gut microbiome composition. Thirty children (7–12 years of age) with functional abdominal pain provided a baseline stool sample prior to randomization to 180, 360, or 540 mg of enteric coated PMO (10 participants per dose). They took their respective dose of PMO (180 mg once, 180 mg twice, or 180 mg thrice daily) for 1 week, after which the stool collection was repeated. Baseline and post‐PMO stools were analyzed for microbiome composition. There was no difference in alpha diversity of the gut microbiome between the baseline and post‐PMO treatment. Principal coordinate analysis revealed no significant difference in overall bacterial composition between baseline and post‐PMO samples, as well as between the PMO dose groups. However, the very low abundant Collinsella genus and three operational taxonomic units (one belonging to Collinsella) were significantly different in samples before and after PMO treatment. The Firmicutes/Bacteroidetes ratio was lower in children who received 540 mg of PMO compared to the 180 mg and 360 mg dose groups (p = 0.04). Network analysis revealed separation between pre‐ and post‐PMO fecal samples with the genus Collinsella driving the post‐PMO clusters. PMO administration appeared to impact only low abundance bacteria. The 540 mg PMO dose differentially impacted the Firmicutes/Bacteroidetes ratio. A higher dose and/or longer duration of treatment might yield different results.