bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between Patient-reported Orofacial-dental Pain Severity and Tele-triage Decisions During COVID-19 Pandemic - Does the Severity of Pain Drive Tele-triage Decisions?
Authors: Ali Shaymaa , Ansari Walid El 
Published: February 2022

Abstract
BACKGROUND: Globally, withCOVID-19 pandemic, elective dental services were stopped, and only urgent/ emergency conditions were managed face-to-face after tele-triage(TT). However, no previous researchexploredwhetherthe severity of orofacial/ dental pain (OFDP)drivesthe TT decisions.The current report undertook this task.METHODS: This retrospective cross-sectional reportanalyzed the pain severity (PS) reported byhotline callers during the first COVID-19 lockdownand its association with patient's age,sex, history of chronic illness,and dental discipline required. PS was also compared across triage categories, associated dental history and tentative tele-diagnosis. PS was measured using self-reported numerical rating scale (NRS-11).Binomial logistic regression assessed the associationbetweenthe PS (exposure) and likelihoodof being referred for face to face management, controlling for age, sex, history of chronic illness, and dental discipline needed. ANOVA compared pain severity (PS) across dental history and tentative diagnosis.RESULTS:PS was significantly associated with TT decisions (p<0.05). An increase in pain score by 1 unit was associated with 1.4 times increased odds of face-face referral. Pediatric/ adolescent patients (9-18 years) were 2.1 times more likely, and those with chronic illness were 2.12 times more likelyto be referred for face-to-facemanagement.Among the dental specialties, surgical and orthodontic specialties were each associated with increased odds of referral (1.9 and 7.016 respectively) compared to restorative specialties.The highest PS was highest for the emergency triage category (8.00 ± 2.83, P< 0.0001),adults (6.29 ± 2.1819, P< 0.0001),and the tentative tele-diagnosis of cellulitis (7.75 ± 2.872, P< 0.0001).CONCLUSIONS: TT decisions were significantly influenced by severity of patient-reported OFDP, adjusting for a range of variables. However, acute dental conditions were not referred when they were judged to be manageable remotely; and conversely, less acute dental conditions were given the attention they required and referred when they hadpotential life threating or quality of life implications. Consideringsuch tele-approach after the pandemic has subsided might be safe and useful in a range of scenarios and healthcare facilities.
New Approach Based on Fuzzy Hypergraphs in Granular Computing (An Application to the Urban Vulnerability Assessment)
Authors: Baghini Abdolreza Zarandi , Babaei Hojjat , Mirhosseini Ramin Tabatabaei 
Published: February 2022

Abstract
Classifying objects based on the simultaneous impact of various parameters has always been challenging due to heterogeneity, impact conflict, and sometimes parameter uncertainty. The purpose of this study is to provide a method for classifying such data. In the proposed method, fuzzy hypergraphs were used to define the granular structures in order to apply the simultaneous effect of heterogeneous and weighted parameters in the classification. This method has been implemented and validated on Fisher intuitive research in relation to the classification of iris flowers. Evaluation and comparison of the proposed method with Fisher’s experimental and results showed higher efficiency and accuracy in flower classification. The proposed method has been used to assess the seismic risk of 50,000 buildings based on 10 heterogeneous parameters. Seismic risk classification showed that more than 88% of buildings were classified, and 12% of buildings that could not be classified due to excessive scatter of parameter values were classified using a very small confidence radius. The results indicate the ability of the proposed method to classify objects with the least similarity and number of effective parameters in classification.
Release Strategies of Telenomus Podisi for Control of Euschistus Heros: A Computational Modeling Approach
Authors: Weber Igor Daniel , Garcia Adriano Gomes , Bueno Adeney de Freitas , Freitas Regiane Cristina de Oliveira , Godoy Wesley Augusto Conde 
Published: February 2022

Abstract
The egg-parasitoid wasp Telenomus podisi has received attention as a biological-control agent for one of the most important soybean pests in Brazil, the stink bug Euschistus heros. As yet, no studies have conclusively established strategies for the release of T. podisi. We developed a computational model employing cellular automata to investigate release strategies for T. podisi in soybean crops, in order to optimize the use of these wasps in managing E. heros. A computational model was developed, using cellular automata in the C programming language and assuming a two-dimensional grid of cells corresponding to a soybean field. The biological dynamics of E. heros and T. podisi were programmed. The following parameters for release strategy were investigated: release mode, number of releases, number of parasitoids per hectare per release, and spacing between release points or strips. The sensitivities of the release and movement parameters were analyzed. The release strategies capable of maintaining an E. heros population below the Economic Threshold level involved releasing a total of at least 15,000 female parasitoids per hectare, in three or four releases of 5,000 or more. A 25-m spacing between release points or strips was indicated. The theoretical results produced by the computational model are expected to guide future field studies to improve T. podisi release plans for managing E. heros in soybeans.
Identifying potential regulators of JAGGED1 expression in portal mesenchymal cells.
Authors: Nishino Teppei , Yoshihara Masaharu , Nakayama Takahiro , Tsuchiya Takaho , Tahara Saeko , Ozaki Haruka , Takahashi Satoru 
Published: February 2022

Abstract
Objective: Portal mesenchymal cells induces the epithelial differentiation of the bile ducts in the developing liver via one of the Delta-Notch signaling components, JAGGED1. Although this differential induction is crucial for normal liver physiology as its genetic disorder (Alagille syndrome) causes jaundice, the molecular mechanism behind JAGGED1 expression remain unknown. Here, we searched for upstream regulatory transcription factors of JAGGED1 using an integrated bioinformatics method.Results: According to DoRothEA database, which integrated multiple lines of evidence on the relation between transcription factors and its downstream target genes, three transcription factors were predicted to be upstream of JAGGED1: SLUG, SOX2 and EGR1. Among these, SLUG and EGR1 were enriched in ACTA2 expressing portal mesenchymal cells in the previously reported two human fetal liver single cell RNA-seq data. JAGGED1 expressing portal mesenchymal cells tended to express of SLUG rather than EGR1, supporting that SLUG induced JAGGED1 expression. Together with the higher confidentiality of SLUG (DoRothEA level A) over EGR1 (DoRothEA level D), we concluded that SLUG was one of the most important candidate transcription factors upstream of JAGGED1. These results would add mechanistic insights into developmental biology on how portal mesenchymal cells supports biliary development in the liver.
Theoretical study on the reactions of C2H5 with CnH2n+1OH (n = 1 - 4): Predicted rate constants and branching ratios
Authors: Nguyen Trong-Nghia , Tuan Vu Anh , Bac Phung Thi Viet , Anh Le Phuoc , Nguyen Hue Minh Thi 
Published: February 2022

Abstract
The mechanisms of the reactions of C2H5 with CnH2n+1OH (n = 1-4) have been investigated by CCSD(T)//B3LYP/6-311++G(3df,2p) for n = 1 - 3 and CCSD(T)//B3LYP/6-311+G(d,p) for n = 4. Our chemical quantum results show that the C2H5 + CH3OH reaction can take place via H-abstraction or substitution channels. The former is the major channel with barrier energies of 13.0 and 14.4 kcal/mol while the latter has to pass over much higher barriers of 42.2 – 52.3 kcal/mol. Similarly, the C2H5 + CnH2n+1OH (n = 2 - 4) reactions can mainly occur via H-abstraction channels with barrier energies of 10.4 - 16.4 kcal/mol. The b-H abstraction channel has the lowest barrier energy (11.7 kcal/mol) for t-C4H9OH while o/a-H abstraction channels have the lowest barrier energies (10.4 - 13.0 kcal/mol) for the others. The rate constants and product branching ratios for individual channels as well as total rate constants have been calculated for the temperature range 300-2500 K by TST theory with Eckart tunneling corrections. The optimized geometries of the related species and predicted heats of reactions agree well with available data.
The Driving Effect Of Technological Innovation On Green Development: Dynamic Efficiency Spatial Variation
Authors: Cheng Manli , Wen Zongguo , Yang Shanlin 
Published: February 2022

Abstract
High-tech industry has become an important position for international competition due to its strong technological innovation capabilities. Green development of the manufacturing industry is an important measure to respond to the profound changes in the global manufacturing industry, and technological innovation is the core force to drive the green development of the manufacturing industry. However, DEA model usually employed to measure the efficiencies of the innovation and green development, the internal transmission mechanism has not been thoroughly explored. In order to open the black box, this paper utilize the high-tech industry data to measure the efficiency of technological innovation process by using network Slack Based Measure (NSBM), Global Malmquist Luenberger index model (GML) is employed to evaluate and decompose the green development efficiency of high-tech industry, and the influencing mechanism between the efficiency of technological innovation and the efficiency of green development is explored by the spatial Dubin model. The results indicate that green transformation of the manufacturing industry has an obvious spatial linkage effect. In addition, technological innovation efficiency is conducive to the green development efficiency, while economic transformation efficiency and urbanization are not conducive to the green development efficiency.
Introduction and Propagation Properties of Circular Lorentz-Bessel-Gaussian Beams
Authors: Ebrahim Ahmed Abdulrab Ali , Yahya Nabil A.A. , Swillam Mohamed , Belafhal Abdelmajid 
Published: February 2022

Abstract
In this paper, circular Lorentz–Bessel–Gaussian beams (CLBGBs) are introduced as a novel member of the Lorentz-Gaussian beams family. The analytical expression of the propagation of these beams passing through a paraxial optical ABCD system is derived. The generalized Huygens-Fresnel diffraction integral of the form Collins’s formula and the expansion of the Lorentz distribution in terms of the complete orthonormal basis set of the Hermite-Gauss modes are used. The influences of the beam-order and Bessel part β, Gaussian and Lorentzian waists, and propagation distance z on the propagation of CLBGBs are investigated. Some numerical simulation results are done. The beams family in this work may be useful to the practical applications in free-space optical communications because they have vortex properties with their being experimentally realizable.
Anesthesia Aspects of Multivisceral Transplantation: A Case Series Study
Authors: Khalili Fatemeh 
Published: February 2022

Abstract
Background
Multi-visceral transplantation (MVTx) usually refers to the transplantation of more than three intra-abdominal organs. A successful MVT procedure requires strong multidisciplinary teamwork of transplant surgeons, anesthesiologists, and intensivists.
Case presentation:
We present 5 cases of MVT with a history of short bowel syndrome admitted to the Abu-Ali Sina Hospital, Shiraz, Iran between May 2019 and January 2020 and describe anesthetic considerations in MVT. Subjects were identified (4F/1M) with a mean age of 43 years old (range 35–51). The most frequent criterion was Portal vein thrombosis followed by bowel gangrene and short bowel syndrome. The mean ±SD duration of the operation was 360±60 min. The approximate bleeding volume was 2600 ±1474 cc and the 4±1 bag packed red blood cells were transfused.
Conclusion
Careful preoperative planning, vigilant intraoperative anesthetic management, and prevention of postoperative infection are imperative to reach the best outcomes.
Prediction of the diagnostic and prognostic values of homeobox family in lung cancer using bioinformatics
Authors: HU TINGTING , Gao PanJun , Jiang Min , Li Zheng , Xu Dan , Jing Jing , WANG JING 
Published: February 2022

Abstract
Background: Lung cancer is a frequently diagnosed malignancy and accounts for the main reason of cancer-related deaths worldwide due to the less of reliable diagnostic markers and the potent therapeutic targets. Therefore, exploration of the molecular mechanisms underlying the occurrence and development via systems biology approaches provides a promising option. Here, we aimed to reveal genes which could be used as the diagnostic and prognostic markers in lung cancer, aiming to find new efficient target for treatment using bioinformatics method. Results: We adopted a series of bioinformatics methods to identify genes which are implicated in the progression of lung cancer. From the raw RNA microarray data obtained from the database of UCSC-Xena, we identified that a total of 241 differently expressed genes (DEGs), including 8 HOX (homeobox) genes in all types of lung cancer tissues (Stage I-IV) as compared to the normal lung tissues. The gene ontology (GO) analysis showed that the 241 DEGs were mainly enriched in xenobiotic glucuronidation, regionalization, GABA receptor complex, and extracellular ligand-gated ion channel activity. Gene expression profiling interactive analysis (GEPIA) demonstrated that the expression levels of HOXA11, HOXA13, HOXB9, HOXB13, HOXC11, HOXC13, HOXD11 and HOXD13 were all obviously higher in lung adenocarcinoma and squamous cell lung carcinoma tissues than in normal lung tissues. Kaplan-Meier survival analysis and operating characteristic analyses (ROC) suggested that the high expression of HOXA11/A13/B9/B13/C11/C13/D11/D13 all predicted poor prognosis of lung cancer and had high specificity and sensitivity in distinguishing lung cancer patients from healthy individuals. Conclusion: This study using bioinformatics methods identified that 8 genes (HOXA11/A13/B9/B13/C11/C13/D11/D13) of HOX family might play an important role in lung cancer progression with high value in the diagnosis and prognostic prediction in lung cancer. However, their role in lung cancer progression still need to be verified using the fundamental experiments.
Prenatal Exposure to Diethylhexyl Phthalate Impairs the Recovery of Spatial Memory Post-traumatic Brain Injury in a Sex-specific Manner
Authors: Sun Min Kyoung , Kaimal Amrita , Latchoumane Charles-Francois V , Forghani Rameen , Lenear Christopher E , Holmes Phillip V , Mohankumar Sheba M.J , Karumbaiah Lohitash 
Published: February 2022

Abstract
Background
Diethyl hexyl phthalate (DEHP) is a chemical plasticizer that causes significant neurological impairments after prenatal exposure. The impact of these exposures on cognitive recovery after severe traumatic brain injury (sTBI) has never been studied. We hypothesized that prenatal exposure to DEHP will impair cognitive recovery after a sTBI in a sex-specific manner.
Methods
To test this hypothesis, six-month-old male and female offspring that were prenatally exposed to DEHP were subjected to controlled cortical impact injuries, and their spatial memory was tested weekly using a Morris Water Maze (MWM) test for 4 weeks post-sTBI.
Results
We observed that DEHP-exposed male rats demonstrated significantly impaired spatial memory up to four weeks post-sTBI when compared to controls. In contrast, DEHP-exposed female rats showed no detectable impairment in spatial memory recovery compared to injured controls. These observations were accompanied by marked increases in neurotransmitter levels in the cortex and dopamine levels in the hippocampus of female, but not in male rats. No significant differences in lesion area and number of hippocampal neurons were observed in both sexes.
Conclusion
These results suggest that prenatal exposure to DEHP may have long lasting effects in the brain that could lead to impaired recovery specifically in male subjects following post-sTBI.
Autoimmune Lymphoproliferative Syndrome (Alps) Disease and Alps Phenotype: Are They Two Distinct Entities?
Authors: Palmisani Elena , Miano Maurizio , Grossi Alice , Lanciotti Marina , Lupia Michela , Terranova Paola , Ceccherini Isabella , Montanari Eugenia , Calvillo Michaela , Pierri Filomena , Micalizzi Concetta , Maggiore Rosario , Guardo Daniela , Zanardi Sabrina , Facchini Elena , Maggio Angela , Mastrodicasa Elena , Corti Paola , Russo Giovanna , Pillon Marta , Farruggia Piero , Cesaro Simone , Barone Angelica , Tosetti Francesca , Ramenghi Ugo , Crescenzio Nicoletta , Bleesing Jack , Dufour Carlo , Fioredda Francesca 
Published: February 2022

Abstract
Introduction
Autoimmune Lymphoprolypherative Syndrome (ALPS) is an inherited disorder of lymphocyte homeostasis classically due to mutation of FAS, FASL, and CASP10 genes (ALPSFAS/CASP10). In spite of recent progress, about one third of ALPS patients does not carry classical mutations and still remains gene orphan (ALPS-U, undetermined genetic defects).
Objective
The aims of the present study were to compare the clinical and immunological features of ALPSFAS/CASP10 vs those of ALPS-U affected subjects and to deepen the genetic characteristics of this latter group.
Methods
Demographical, anamnestic, biochemical data were retrieved from medical record of 42 ALPS subjects. An enlarged panel of genes (Next Generation Sequencing) was applied to the ALPS-U group.
Results
ALPS-U subjects showed a more complex phenotype if compared to ALPSFAS/CASP10 group, characterized by multi-organ involvement (p=0.001) and positivity of autoimmune markers (p= 0.02). Multilineage cytopenia was present in both groups without differences with the exception of lymphocytopenia and autoimmune neutropenia that were more frequent in ALPS-U than in ALPS-FAS/CASP10 group (p=0.01 and p=0.04). First and second line treatments were able to control the symptoms in 100% of the ALPSFAS/CASP10 patients, while 63% of ALPS-U needed more than two lines of treatment and remission in some cases was obtained only after target therapy. In the ALPS-U group, we found in 14/28 (50%) patients 19 variants; of these 4/19 (21%) were known as pathogenic, 8/19 (42%) as likely pathogenic. A characteristic flow cytometry panel including CD3CD4-CD8-+TCRαβ+, CD3+CD25+/CD3HLADR+, TCR αβ + B220+ and CD19+CD27+ identified the ALPS FAS/CASP10 group.
Trans-abdominal and Trans-gastric percutaneous drainage of peripancreatic infected collections: a retrospective analysis.
Authors: Rey Carlos , Conde Danny , Girón Felipe , Ayala Daniela , Gonzalez Juliana , Quintero Marco 
Published: February 2022

Abstract
PurposeAcute pancreatitis is one of the most common gastrointestinal diseases. Approximately 20% of the patients develop peripancreatic collections. Step-up management it’s now the best approach with less rate of morbidity and mortality compared with open or minimally invasive surgery. Percutaneous management could reach a success rate between 50-76%. Our study shows the outcomes of trans-gastric versus transabdominal percutaneous drainage in cases of peripancreatic collections. MethodsA retrospective review of a prospectively collected database was conducted. All the patients older than 18 years old that underwent percutaneous drainage between January 2010 – December 2021 were included. Analysis and description of outcomes such as mortality, complications, and avoidance of surgical procedures was performed.Results18 patients underwent percutaneous drainage. 66.67% of patients were male. Mean age was 52.55 ± 22.06 years. Mean weight was 74.43 ± 15.25 kg. Mean size of peripancreatic collections 118.4 ± 49.12mm. Wall-off necrosis was present in 33.33%. Trans-gastric approach was performed in 50% of the cases, the rest was trans-abdominal. No mortality was evidenced after 30 days of follow up. After trans-gastric percutaneous drainage, all patients avoided surgical open or laparoscopic procedureConclusionStandardized step-up approach shows increased rates of success in percutaneous drainage of peripancreatic collections. Based on our results, in the absence of interventionist endoscopy, percutaneous drainage (trans gastric or trans-abdominal) it’s a feasible and secure procedure. Further studies are needed.
Transcriptomic analysis of differential gene expression in staphylococcus aureus-induced pneumonia in pediatrics based on microarray analysis
Authors: Ehigie Adeola Folashade , Ojeniyi Fiyinfoluwa Demilade , Aborisade Adetayo , Agboola James Busayo , Ehigie Leonard 
Published: February 2022

Abstract
Staphylococcus aureus is a leading cause of about 80% of infections in humans and up to 60–70% of hospital-acquired infections. Pneumonia is the broad term for a range of disorders that result in infection of the lung parenchyma and are caused by a number of organisms. It is a common disease that affects people from all walks of life. Identification of an etiologic agent for pneumonia is critical in order to provide appropriate therapy and maintain epidemiological records. Study on the transcriptional profiling of patients infected with S. aureus is a pivot to the analysis of differentially expressed gene in the blood of patients infected with S. aureus. This study performed the analysis of gene expression dataset GSE30119 available on the Gene expression Omnibus (GEO) which is based on the hypothesis tested that patient clinical heterogeneity will be reflected in transcriptional profile heterogeneity. The study comprised 143 pediatric patients, with 44 healthy individuals, 81 pneumonia-free, and 18 pneumonia infection patients. We discovered a total of 54 genes related to S. aureus infection and 612 genes associated with Pneumonia. According to Gene Ontology (GO) functional and pathway enrichment studies, the S. aureus infection associated genes are predominantly engaged in the innate immune response, calcium-mediated signaling, Neutrophil extracellular trap formation, Formation of Fibrin Clot (Clotting Cascade). Whereas the genes associated with Pneumonia are enriched in adaptive immune response, inflammatory, Interferon alpha/beta signaling, TCR signaling, Gα(i) signalling events. This study shows differentially expressed genes and their biological activities in relation to S. aureus infection and Pneumonia, and it may provide more light on the underlying molecular mechanisms and possibly important gene signatures in Pneumonia development.