bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estudo da frequência e da caracterização das infecções por Klebsiella pneumoniae carbapenemase em um hospital dos Campos Gerais
Authors: Dudkiewicz Fábio Marcelo , Bail Larissa , Ito Carmen Antônia Sanches , Gaspar Maria Dagmar da Rocha , Castro João Pedro Wardani de , Montes Elisangela Gueiber 
Published: December 2022

Objetivo: Determinar o perfil e a prevalência das infecções relacionadas a Klebsiella pneumoniae carbapenemase na assistência à saúde. Metodologia: Este foi um estudo transversal descritivo retrospectivo (Yin, 2015) e analisou o perfil dessas infecções em um único hospital público entre 2019 e 2021, por meio da coleta de dados com o Núcleo de Controle de Infecção Hospitalar e em prontuários eletrônicos. Os dados coletados incluíram informações demográficas, clínicas e laboratoriais relacionados a infecção. Resultados: Foram analisados 59 pacientes com infecção associada a KPC (8,3%, 65/780), sendo a Klebsiella pneumoniae a espécie mais isolada (93,4%, 57/61). O maior número de infecções foi encontrado na unidade de terapia intensiva (76,7%, 46/60), a maioria relacionado a pneumonia associada a ventilação (29,2%, 19/65), a presença de 3 comorbidades ou mais (55,9%, 33/59) e assistidos com pelo menos um dispositivo invasivo (78%, 46/59). Antibioticoterapia prévia foi encontrada em 96,7% (58/60) e, após a cultura, 31,7% recebeu amicacina e polimixina B. Desses pacientes, 66,1% (39/59) evoluíram a óbito e 33,9% (20/59) receberam alta hospitalar. Conclusão: os resultados estão em concordância com a literatura atual, destacando a importância das medidas preventivas à disseminação de agentes multirresistentes e o impacto da pandemia do COVID-19 no aumento das IRAS por bactérias Gram-negativas.
Miomodulação como tratamento na correção do sorriso gengival: uma alternativa viável?
Authors: Souza Hígor Cruz de , Mota Larissa Vaz Pereira , Coelho Patrícia Maria 
Published: December 2022

Introdução: A busca por um sorriso estético faz com que mais pessoas procurem os consultórios odontológicos, já que a odontologia possui diversos mecanismos para proporcionar um sorriso harmônico para o paciente. Uma das possibilidades terapêuticas para correção do sorriso gengival se dá por meio do uso de ácido hialurônico (miomodulação), técnica com resultados satisfatórios para o paciente e menos invasiva, quando se compara com outras modalidades de tratamento. Objetivo: Relatar um caso clínico, de sorriso gengival, em que a opção de tratamento foi a miomodulação. Relato de caso: Paciente do sexo feminino apresentou como queixa principal a exposição gengival do sorriso. Foi realizada avaliação, por meio de exame clínico e fotográfico, e escolhido o músculo levantador do lábio superior da asa do nariz como alvo para controlar sua atividade e restringir o movimento muscular. Será realizada a aplicação de 0,4ml de ácido hialurônico em cada lado e o devido acompanhamento do caso clínico. Conclusão: A realização de um diagnóstico criterioso é de extrema importância para avaliar a causa primária do sorriso gengival, para que assim, seja promovido ao paciente o melhor plano de tratamento possível.
Amamentação e doação de leite nos bancos de leite humano brasileiros: Uma revisão da literatura
Authors: Anjos Sarah Peres Amorim , Luiz Ana Cecília Gomes Rosa , Silva Victória Franco , Pereira Vinicius Santana 
Published: December 2022

O objetivo desse artigo é desenhar um panorama geral da doação de leite e da amamentação no contexto dos Bancos de Leite Humano brasileiros. Isso foi feito a partir da seleção e revisão das principais referências bibliográficas acerca desse tema. Os artigos foram pesquisados nas bases de dados SciELO, LILACS, Google Acadêmico e PubMed. Após a leitura e análise dos artigos foram selecionados 13 artigos que se enquadram no escopo de análise desse artigo. Na discussão foram elencadas as principais variáveis que impactam na doação de leite e na amamentação, sejam elas positivas ou negativas. Dentre essas, pode-se citar: esclarecimento da nutriz feito por profissionais de saúde, grau de escolaridade da nutriz e nível socioeconômico da nutriz. Conclui-se que a falta de recurso humano e de capacitação dos profissionais que atuam nos bancos de leite representa grande entrave para a captação de nutrizes e para a expansão do programa de doação de leite como um todo, visto que ainda hoje, há pouco esclarecimento sobre o processo de amamentação e ainda mais sobre o processo de doação de leite, o que diminui o poder de atuação da rede de bancos de leite brasileira.
Exodontia preventiva de terceiros molares: uma revisão integrativa
Authors: Oliveira Neto José Lopes de , Afonso Áquila de Oliveira , Araújo Felipe Rafael da Cunha , Cintra Thamires do Prado , Carneiro Grace Kelly Martins , Lima Mabel Martins , Carvalho Caio Muniz , Braga Marcos Dyllan de Souza , Sena César Vinícius Gato , Silva Evanio da 
Published: December 2022

Os terceiros molares exibem a maior variabilidade no tempo de desenvolvimento, coroa e morfologia radicular e posição. São os últimos dentes a irromper na cavidade oral e complementam a função dos segundos molares. A erupção ou impactação desses dentes é uma consideração importante no planejamento do tratamento e na manutenção da dentição a longo prazo e, portanto, de particular interesse para o ortodontista e o dentista. Dessa forma, o objetivo da presente revisão de literatura é descrever as indicações para a remoção profilática de terceiros molares, discorrendo sobre as principais vantagens e desvantagens, bem como as possíveis complicações relacionadas ao procedimento cirúrgico. Para a construção deste trabalho foi feito um levantamento bibliográfico nas bases de dados SciVerse Scopus, Scientific Eletronic Library Online (Scielo), U.S. National Library of Medicine (PUBMED) e ScienceDirect, utilizando o gerenciador de referências Mendeley. Existem indicações claras para a remoção de terceiros molares associados à patologia. No entanto, terceiros molares impactados irrompidos assintomáticos devem ser deixados sozinhos e monitorados regularmente. Os terceiros molares parcialmente ou totalmente irrompidos assintomáticos também devem ser monitorados periodicamente. Quando os terceiros molares parciais ou totalmente erupcionados assintomáticos exibem patologia periodontal, como bolsas ≥ 4 mm, sangramento à sondagem ou perda de inserção, uma abordagem conservadora envolvendo a manutenção periodontal é recomendada. O clínico também está justificado em decidir extrair o(s) terceiro(s) molar(es) se a higiene oral for média e a progressão da doença for provável.
Bibliometric analysis of the inflammation in diabetic cardiomyopathy
Authors: Zhu Ning , Huang Bingwu , Zhu Liuyan 
Published: December 2022

BackgroundMaladaptive inflammation is implicated in the development of diabetic cardiomyopathy (DCM). This study aimed to visually analyze the global scientific output over the past two decades regarding research on inflammation associated with DCM.MethodsAll relevant articles and reviews were retrieved in the Web of Science (WOS) Core Collection (limited to SCIE) using “inflammation” and “diabetic cardiomyopathy” as search terms. Articles and reviews published from 1 January 2001 to 28 February 2021 were collected. Visualization analysis and statistical analysis were conducted by Microsoft 365 Excel and VOSviewer 1.6.18.ResultsA total of 578 documents were finally selected for further analysis. The publications regarding inflammation and DCM increased gradually over approximately 20 years. The most prolific country was China, with 296 documents and the most citations (9,366). The most influential author groups were Lu Cai and Yihui Tan who were from the United States. The bibliometric analysis of co-occurrence keywords showed that inflammation in DCM is composed of numerous molecules (NF-κB, NLRP3 inflammasome, Nrf-2, TNF-α, protein kinase C, PPARα, TLR4, p38 mitogen-activated protein kinase, TGF-β, Sirt1, and AKT), a variety of cardiac cell types (stem cell, fibroblast, and cardiomyocyte), physiological processes (apoptosis, oxidative stress, autophagy, endoplasmic reticulum stress, hypertrophy, mitochondrion dysfunction, and proliferation), and drugs (sulforaphane, metformin, empagliflozin, and rosuvastatin).ConclusionOur bibliometric analysis presents the characteristics and trends of inflammation in DCM and shows that research on inflammation in DCM will continue to be a hotspot.
Contactless multiscale measurement of cardiac motion using biomedical radar sensor
Authors: Qiao Jia-hao , Qi Fu-gui , Liang Fu-lai , Ma Jin , Lv Hao , Yu Xiao , Xue Hui-jun , An Qiang , Yan Ke-ding , Shi Ding , Qiao Yong-hui , Wang Jian-qi , Zhang Yang 
Published: December 2022

IntroductionA contactless multiscale cardiac motion measurement method is proposed using impulse radio ultra-wideband (IR-UWB) radar at a center frequency of 7.29 GHz.MotivationElectrocardiograph (ECG), heart sound, and ultrasound are traditional state-of-the-art heartbeat signal measurement methods. These methods suffer from defects in contact and the existence of a blind information segment during the cardiogram measurement.MethodsExperiments and analyses were conducted using coarse-to-fine scale. Anteroposterior and along-the-arc measurements were taken from five healthy male subjects (aged 25–43) when lying down or prone. In every measurement, 10 seconds of breath-holding data were recorded with a radar 55 cm away from the body surface, while the ECG was monitored simultaneously as a reference.ResultsCardiac motion detection from the front was superior to that from the back in amplitude. In terms of radar detection angles, the best cardiac motion information was observed at a detection angle of 120°. Finally, in terms of cardiac motion cycles, all the ECG information, as well as short segments of cardiac motion details named blind ECGs segments, were detected.SignificanceA contactless and multiscale cardiac motion detection method is proposed with no blind detection of segments during the entire cardiac cycle. This paves the way for a potentially significant method of fast and accurate cardiac disease assessment and diagnosis that exhibits promising application prospects in contactless online cardiac monitoring and in-home healthcare.
The effect of metformin usage on survival outcomes for hepatocellular carcinoma patients with type 2 diabetes mellitus after curative therapy
Authors: Yuan Bo , Ma Jichun , Wang Jing , Hao Jinyong 
Published: December 2022

ObjectiveMetformin has attracted more attention from researchers for its newly discovered antitumor effects. A meta-analysis was performed to reveal the efficacy of metformin on overall survival (OS) and recurrence-free survival (RFS) for HCC patients with type 2 diabetes mellitus (T2DM) after curative treatment.MethodsDatabases including PubMed, the Cochrane Library, Web of Science, CNKI, Wangfang, and Weipu Database up until 31 May 2022 were searched for relevant studies. STATA 13.0 was used to perform the meta-analysis.ResultsA total of six studies involving 5,936 patients were included in our study. The results from the current study revealed that metformin usage can significantly prolong the 3-year [odds ratio (OR) = 1.50, 95% confidence interval (CI): 1.22–1.83, p = 0.000] and 5-year (OR = 1.88, 95% CI: 1.47–2.41, p = 0.000) OS and decrease the 1-year (OR = 1.31, 95% CI: 1.08–1.59, p = 0.007), 3-year (OR = 1.88, 95% CI: 1.48–2.37, p = 0.000), and 5-year (OR = 1.83, 95% CI: 1.40–2.40, p = 0.000) recurrence rates.ConclusionMetformin treatment significantly prolongs the OS and decreases the recurrence rate for HCC patients with T2DM after curative HCC therapy.
Evaluation value of subjective visual quality examination on surgical indications of the early cataracts based on objective scatter index values
Authors: Li Yuzhi , Jin Ling , Wu Mingfeng , Huang YuKan 
Published: December 2022

AimTo evaluate the subjective visual functions of early cataracts patients and assess their surgical indications.MethodsEyes were separated into a control group (Group A without cataract) and two early cataracts groups (Group B with 2.0 ≤ OSI &lt; 3.0 and Group C with 3.0 ≤ OSI &lt; 4.0). The objective scatter index (OSI), modulation transfer function cut-off frequency (MTF cut-off), and Strehl ratio (SR) values were applied to measure objective visual functions. The contrast sensitivity (CS) and scores of the questionnaires (QOL and VF-14) characterized subjective visual functions. Above visual functions were compared among three groups. Postoperative visual functions in Group B and C were analyzed to assess the outcome of surgery.ResultsNinety two subjects (126 eyes) were included in the study. All objective visual function in Group B were significantly better than Group C (all P &lt; 0.01), but worse than Group A (all P &lt; 0.01). Except for 1.5 c/d CS, subjective visual function in Group A were significantly better than Group B and C (all P &lt; 0.05), but there was no significant differences between Group B and C. As for eyes that underwent surgery in Group B and C, all visual functions significantly improved after surgery (P &lt; 0.05), except for 1.5 c/d CS in Group C. There were no significant differences among the three groups after surgery.ConclusionThe subjective visual function can be impaired in early cataracts patients with OSI &lt; 3.0, whose objective visual functions were statistically better than patients with OSI ≥ 3.0. These patients can benefit equally from surgery as patients with OSI ≥ 3.0. Subjective visual functions can be used as surgical indications for these patients.
The potential diagnostic accuracy of urine formaldehyde levels in Alzheimer’s disease: A systematic review and meta-analysis
Authors: Chen Fan , Wang Na , Tian Xinyan , Qin Yan , Su Juan , He Rongqiao , He Xiaping 
Published: December 2022

BackgroundFormaldehyde (FA), a toxic aldehyde, has been shown to be associated with a variety of cognitive disorders, including Alzheimer’s disease (AD). There is increasing evidence that FA levels are significantly increased in AD patients and may be involved in the pathological process of AD. The aim of this study was to assess the potential diagnostic value of urine FA levels in AD using meta-analysis techniques.MethodsOriginal reports of morning urine FA levels in AD patients and healthy controls (HCs) were included in the meta-analysis. Standardized mean differences (SMD) were calculated using a random-effects model, heterogeneity was explored using methodological, age, sex difference and sensitivity analyses, and receiver operating characteristic (ROC) curves were constructed to assess the diagnostic value of urine FA levels in AD.ResultsA total of 12 studies were included, and the urine FA levels of 874 AD patients and 577 HCs were reviewed. Compared with those in HCs, the FA levels were significantly increased in AD patients. The heterogeneity of the results did not affect their robustness, and results of the area under the curve (AUC) suggested that urine FA levels had good potential diagnostic value.ConclusionUrine FA levels are involved in AD disease progression and are likely to be useful as a potential biomarker for clinical auxiliary diagnosis. However, further studies are needed to validate the results of this study.
The 3D characteristics of nystagmus in posterior semicircular canal benign paroxysmal positional vertigo
Authors: Liu Yao , Zhang Xueqing , Deng Qiaomei , Liu Qiang , Wen Chao , Wang Wei , Chen Taisheng 
Published: December 2022

ObjectiveThe aim of this study was to observe the 3-dimensional (3D; horizontal, vertical, and torsional) characteristics of nystagmus in patients with posterior semicircular canal canalithiasis (PSC-can)–related benign paroxysmal positional vertigo (BPPV) and investigate its correlation with Ewald’s.MethodsIn all, 84 patients with PSC-can were enrolled. The latency, duration, direction, and slow-phase velocity induced by the Dix-Hallpike test in the head-hanging and sitting positions were recorded using 3D video nystagmography (3D-VNG). The characteristics of the horizontal, vertical, and torsional components of nystagmus were quantitatively analyzed.Results3D-VNG showed that the fast phase of the vertical components and torsional components of left and right ear PSC-can as induced by the head-hanging position of the Dix-Hallpike test were upward, clockwise and counterclockwise, and horizontal components were mainly contralateral. The median slow-phase velocity of each of the three components for consecutive 5 s was 26.3°/s (12.3–45.8), 25.0°/s (15.7–38.9), and 9.2°/s (4.9–13.7). When patients were returned to the sitting position, the fast phase of the vertical and torsional components of nystagmus was reversed. Only 54 patients had horizontal components of nystagmus, and 32 of them remained in the same direction. The median slow-phase velocity of the three components for consecutive 5 s was 9.4°/s (6.0–11.7), 6.8°/s (4.5–11.8), and 4.9°/s (2.8–8.0). The ratios of the slow-phase velocity of the horizontal, vertical, and torsional components of the head-hanging position to the sitting position were close to 1.85 (1.0–6.6), 3.7 (1.9–6.6), and 5.1 (2.6–11.3). The ratios of the slow-phase velocity of the vertical to horizontal component, the torsional to horizontal component, and the vertical to torsional component of the head-hanging position were close to 3.3 (1.7–7.6), 3.9 (1.8–7.6), and 1.0 (0.5–1.8). The ratios of the slow-phase velocity of the vertical to horizontal component, the torsional to horizontal component, and the vertical to torsional component of the sitting position were close to 2.1 (1.1–6.8), 1.5 (1.0–3.8), and 1.2 (0.8–2.8).ConclusionThere were three components of nystagmus induced by the Dix-Hallpike test in patients with PSC-can. The vertical component was the strongest and the horizontal component was the weakest. The 3D characteristics of nystagmus were consistent with those of physiological nystagmus associated with the same PSC with a single-factor stimulus, in accordance with Ewald’s law.
Patient perceptions of virtual reality for pain relief in labor: A qualitative study
Authors: Wong Melissa S. , Gregory Kimberly D. , Spiegel Brennan M. R. , Khalil Carine 
Published: December 2022

IntroductionLabor represents the most common reason for hospitalization, and most patients will use some form of pain management during their labor. While some studies have suggested that virtual reality (VR) may be an effective option for managing pain, more study is necessary to understand the patient experience of VR. The aim of this study is to characterize the effect of VR on patient perceptions of coping in labor and their descriptions of the VR experience.MethodologyA nested prospective, descriptive study within a randomized controlled trial of VR in laboring patients. We included nulliparous, term patients, having contractions at least every 5 min, a pain score on the Wong-Baker pain scale of 4–7, and who had been randomized to receive the 30 min virtual reality intervention in the trial. Subjects completed a childbirth self-efficacy inventory prior to the intervention. After the intervention, they completed a modified childbirth self-efficacy inventory related to VR and underwent a structured interview. Self-efficacy scores were compared using t-tests and qualitative, thematic analysis was performed using Dedoose.ResultsTwenty-one subjects received the VR intervention. Twenty subjects completed the post-intervention survey and structured interview; one declined due to discomfort. Subjects noted a significant increase in perceived degree to which VR could improve their self-efficacy in managing pain during labor. Thematic analysis revealed that subjects described the VR experience as allowing them to connect with their breathing, feeling more relaxed, and being distracted from pain. In total, 70% believed VR reduced their pain, 60% felt it reduced their anxiety, and 100% would recommend VR availability for laboring patients.ConclusionVR can improve patient self-efficacy for managing pain in labor. Future studies should focus on the content of the visualizations, optimized user experience and design, and effectiveness with ongoing exposure to VR content in labor.
Low-frequency ultrasound irradiation increases paclitaxel-induced sarcoma cells apoptosis and facilitates the transmembrane delivery of drugs
Authors: Yang Tana , Zhang Yixuan , Wang Tan , Li Mo , Zhang Ying , Zhao Dan , Xu Libin , Wang Xiaobing 
Published: December 2022

Sarcoma is a malignant tumor derived from interstitial tissues and requires comprehensive treatment including chemotherapy. Paclitaxel (PTX) is an active agent against sarcoma, but its effect is not sufficiently acceptable and needs to be improved. Low-frequency ultrasound (LFU) has been documented to improve the efficacy of drugs by inducing reversible changes in membrane permeability; however, the effects of the combined use of LFU and PTX for sarcoma tumors remain unclear and warrant further investigation. We investigated the effects of 30 kHz LFU treatment combined with PTX on sarcoma cells A-204 and HT-1080 by analyzing in vitro apoptosis and cell growth inhibition rates, and determined their antitumor effects by examining tumor weights with or without LFU in the S180 sarcoma xenograft model. Drug concentrations in the subcutaneous tumors were measured using high performance liquid chromatography (HPLC). LFU combined with PTX significantly induced cell apoptosis, and blocked the cell cycle of sarcoma cells in G2/M phase, and furthermore, inhibited the activation of JAK2/STAT3 signaling pathway. Meanwhile, LFU combined with PTX inhibited the expression of PD-L1 in vitro, suggesting the potential of enhanced antitumor immunity by this treatment. LFU combined with PTX significantly inhibited the growth of S180 tumors transplanted subcutaneously in Institute of Cancer Research (ICR) mice, and its enhanced effect may be associated with increased local concentrations of PTX in tumor tissues in vivo, with no significant adverse subsequences on body weight observed. We conclude that the combination of LFU and PTX has synergistic antitumor effects and is a candidate for subcutaneous treatment of sarcoma by further increasing the intracellular concentration of PTX.