bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved early-warning estimates of luminosity distance and orbital inclination of compact binary mergers using higher modes of gravitational radiation
Authors: Singh Mukesh Kumar , Divyajyoti  , Kapadia Shasvath J , Shaikh Md Arif , Ajith Parameswaran 
Published: March 2022

ABSTRACTThe pre-merger (early-warning) gravitational-wave (GW) detection and localization of a compact binary merger would enable astronomers to capture potential electromagnetic (EM) emissions around the time of the merger, thus shedding light on the complex physics of the merger. While early detection and sky localization are of primary importance to the multimessenger follow-up, improved estimates of luminosity distance and orbital inclination could also provide insights on the observability of EM emission. In this work, we demonstrate that the inclusion of higher modes of gravitational radiation, which vibrate at higher multiples of the orbital frequency than the dominant mode, would significantly improve the early-warning estimates of the luminosity distance and orbital inclination of asymmetric compact binaries, in particular, neutron-star black hole mergers. This will help astronomers to better determine their follow-up strategy of such systems. Focusing on future observing runs of the ground-based GW detectors, we show that for neutron-star black hole binaries that are potentially EM-bright, the inclusion of higher modes improves the luminosity distance estimates by a factor of ∼1 − 1.5 (1.1 − 2) [1.1 − 5] for the O5 (Voyager) [3G] observing scenario, 45 (45) [300] s before the merger. There are significant improvements in orbital inclination estimates as well. We also investigate these improvements with varying sky-location and polarization angle. Combining the luminosity distance uncertainties with localization skyarea estimates, we find that the number of galaxies within localization volume is reduced by a factor of ∼1 − 2.5 (1.2 − 4) [1.2 − 10] with the inclusion of higher modes in O5 (Voyager) [3G].
Probing the shot behaviour in Cygnus X-1 using simultaneous AstroSat-NICER observation
Authors: Bhargava Yash , Hazra Nandini , Rao A R , Misra Ranjeev , Bhattacharya Dipankar , Roy Jayashree , Alam Md Shah 
Published: March 2022

ABSTRACT
We analyse the aperiodic flaring features, also known as shots, observed in Cyg X-1 in the 0.1–80 keV energy band using a 6.39 ks simultaneous observation with AstroSat and Neutron star Interior Composition ExploreR (NICER). We detect 49 simultaneous shots in the soft and hard X-ray bands with NICER and AstroSat-LAXPC, respectively. We observe the shot profile for the first time in soft X-rays (0.1–3 keV), which shows a spectral peak at ∼2 keV. Using time-averaged spectroscopy, we measured the truncation of the inner accretion disc at 6.7 ± 0.2 gravitational radii. The shot-phase-resolved spectroscopy allowed us to identify the origin of some of the brightest aperiodic peaks in the soft X-rays. We find that the accretion rate is consistent with a constant during the shots while the inner edge of the accretion disc moves inwards/outwards as these shots rise/decay. We discuss the possible mechanisms causing the swing in the inner radius.
Inhibition of the NLRP3 inflammasome by progesterone is attenuated by abnormal autophagy induction in endometriotic cyst stromal cells: implications for endometriosis
Authors: Choi JongYeob , Jo MinWha , Lee EunYoung , Kim Sung Eun , Lee Dong-Yun , Choi DooSeok 
Published: March 2022

Abstract
The NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome is a cytosolic multi-protein complex that induces inflammation and is known to be regulated negatively by autophagy. Previous studies reported an abnormal induction of autophagy linked to progesterone resistance in human endometriotic cells. Therefore, an aberrant autophagy induction response to progesterone might contribute to the altered inflammatory response observed in endometriotic tissues. To evaluate this hypothesis, we elucidate whether regulation of the NLRP3 inflammasome by ovarian steroids is mediated by autophagy in human endometrial stromal cells (normal endometrial stromal cells (NESCs)) from patients with uterine leiomyoma (presumed normal) and whether abnormal autophagy induction in endometriotic cyst stromal cells (ECSCs) affects NLRP3 inflammasome-induced interleukin-1β (IL-1β) production. Our results show that estrogen enhanced NLRP3 inflammasome activation in NESCs, resulting in increased IL-1β production. Progesterone decreased NLRP3 inflammasome activity with an increase in autophagy induction in estrogen-treated NESCs. Inhibition of NLRP3 inflammasome activity by progesterone was blocked by autophagy inhibition. However, progesterone failed to change NLRP3 inflammasome activity and autophagy induction in estrogen-treated ECSCs. In contrast, dienogest, a specific progesterone receptor agonist, reduced NLRP3 inflammasome-mediated IL-1β production through autophagy induction in ECSCs. Furthermore, autophagy induction was decreased and NLRP3 inflammasome activity was increased in endometriotic tissues, which was reversed by preoperative administration of dienogest. In conclusion, our results suggest that progesterone inhibits NLRP3 inflammasome activation through autophagy in endometrial stromal cells. However, this inhibitory effect is attenuated in endometriotic stromal cells due to an aberrant autophagic response to progesterone, which could lead to an altered inflammatory response in endometriosis.
Music Therapy Program Development for Pediatric Patients in a Medical Facility Awaiting Behavioral/Mental Health Placement
Authors: McWaters Sarah , Gettis Margaret , Bourne Joan 
Published: March 2022

Abstract
There is a growing need for support and treatment of individuals experiencing a mental health crisis, especially among the pediatric population. Pediatric patients in need of psychiatric stabilization have little access to supportive services during interim hospitalizations prior to psychiatric admission. The purpose of the evidence-based practice project was to assess if music therapy was an effective intervention to support pediatric behavioral/mental health (BMH) patients awaiting medical stabilization and psychiatric placement. Music therapy services were offered, consisting of interventions to promote positive coping and normalization and to decrease anxiety and behavioral outbursts in pediatric BMH patients. Pre- and post-behavioral states and characteristics of engagement demonstrated a beneficial change after the music therapy session(s) as evidenced by 88.5% of recorded patients reaching a positive behavioral state and 86.9% demonstrating a higher level of engagement. Music therapy was an effective intervention to support pediatric BMH patients awaiting medical stabilization and placement. The availability of music therapy services for BMH patients can produce positive effects for patients, families, and medical staff.
Aligning the Central Brain Tumor Registry of the United States (CBTRUS) histology groupings with current definitions
Authors: Waite Kristin A , Cioffi Gino , Kruchko Carol , Patil Nirav , Brat Daniel J , Bruner Janet M , McLendon Roger E , Tihan Tarik , Ostrom Quinn T , Barnholtz-Sloan Jill S 
Published: March 2022

Abstract

Background
The Central Brain Tumor Registry of the United States (CBTRUS) uses a histology grouping model based on the World Health Organization (WHO) classifications to group records for clinically relevant statistical reporting. Newly identified genetic markers more accurately stratify patients than histology alone and were incorporated into the 2016 update to the WHO Classification.

Methods
CBTRUS and consulting neuropathologists reviewed and aligned histology groupings with the 2016 WHO update. “Obsolete” (terms not currently in use) histology nomenclature along with their International Classification of Disease, Oncology 3rd edition (ICD-O-3) codes were identified, some histologies were reclassified to 2016 WHO, and new codes found in 2016 WHO were incorporated. An evaluation of the frequency of histology codes affected in the realignment process, and incidence and survival pre- and post-realignment was conducted.

Results
After review, 67 codes were noted as obsolete, 51 codes were reclassified, and 12 new codes were incorporated. Histology groups most affected were mesenchymal tumors and neuronal/mixed neuronal-glial tumors. Reorganization resulted in 2588 (0.65%) cases with grouping reassignment or reporting change, indicating that the 2016 WHO Classification revision has impacted the collection and reporting of primary brain and other CNS tumors.

Conclusion
This work demonstrates the need to be responsive to changes in classification and coding in order to ensure the most up-to-date and accurate statistics for brain and CNS tumors. This will require collaboration from all stakeholders within the brain tumor community, so to have the ability to reconcile clinical practices and surveillance requirements.
Kimyrsa, An Oritavancin-Containing Product: Clinical Study and Review of Properties
Authors: Hoover Randall K , Krsak Martin , Molina Kyle C , Shah Kairav , Redell Mark 
Published: March 2022

Abstract

Background
There is a need for improved antibiotic formulations for the treatment of acute bacterial skin and soft structure infection (ABSSSI), especially with the rise of antimicrobial resistance among Gram-positive bacteria. A new formulation of oritavancin was developed to reduce intravenous infusion volume (from 1000 mL to 250 mL), shorten infusion time (from 3 hours to 1 hour), and provide pharmacies with flexibility in oritavancin preparation (from 5% dextrose in sterile water to either normal saline or 5% dextrose in sterile water) compared with the current formulation.

Methods
A total of 102 adult patients with a diagnosis of ABSSSI suspected or confirmed to be caused by a Gram-positive pathogen were randomized 1:1 to receive either the new formulation of oritavancin or the current formulation. After a single 1200-mg intravenous infusion of oritavancin, the relative area-under-the-curve exposure of the new formulation and current formulation groups were compared. Safety and tolerability of the new formulation were assessed for treatment-emergent adverse events, serious adverse events, and changes to laboratory parameters.

Results
The area under the curve for 0 hour to 72 hours postdose was very similar in the new formulation group compared with the current formulation group. No differences in treatment-emergent adverse events were observed between the current and new formulation groups, and all treatment-emergent adverse events were consistent with the known safety profile of the current formulation.

Conclusions
The new formulation of oritavancin with reduced volume and duration of intravenous infusion demonstrates a safety profile and pharmacokinetics similar to that of the original formulation.
Economic Burden of Fungal Diseases in the United States
Authors: Benedict Kaitlin , Whitham Hilary K , Jackson Brendan R 
Published: March 2022

Abstract
We conservatively estimated the US economic burden of fungal diseases as $11.5 billion in 2019: direct medical costs ($7.5 billion), productivity loss due to absenteeism ($870 million), and premature deaths ($3.2 billion). An alternative “value of statistical life” approach yielded &gt;$48 billion. These are likely underestimates given underdiagnosis and underreporting.
Ibrutinib for Hospitalized Adults With Severe Coronavirus Disease 2019 Infection: Results of the Randomized, Double-Blind, Placebo-Controlled iNSPIRE Study
Authors: Coutre Steven E , Barnett Christopher , Osiyemi Olayemi , Hoda Daanish , Ramgopal Moti , Fort Alexander C , Qaqish Roula , Hu Yiran , Ninomoto Joi , Alami Negar N , Styles Lori , Treon Steven P 
Published: March 2022

Abstract

Background
Few therapies are approved for hospitalized patients with severe coronavirus disease 2019 (COVID-19). Ibrutinib, a once-daily Bruton tyrosine kinase inhibitor, may mitigate COVID-19–induced lung damage by reducing inflammatory cytokines. The multicenter, randomized, double-blind phase 2 iNSPIRE study evaluated ibrutinib for prevention of respiratory failure in hospitalized patients with severe COVID-19.

Methods
Adult patients with severe COVID-19 requiring hospitalization and supplemental oxygen but without respiratory failure were randomized 1:1 (stratified by remdesivir prescription) to ibrutinib 420 mg or placebo once daily for up to 28 days plus standard of care (SOC), including remdesivir and/or dexamethasone.

Results
Forty-six patients were randomized to ibrutinib plus SOC (n = 22) or placebo plus SOC (n = 24). The primary endpoint (proportion of patients alive and without respiratory failure through day 28) was not met, with no statistically significant difference adjusting for remdesivir prescription (86% with ibrutinib plus SOC vs 79% with placebo plus SOC; adjusted difference, 5.8% [80% confidence interval, –9.2% to 20.4%]; P = .599). Secondary endpoints also showed no statistically significant improvement with ibrutinib plus SOC. Median treatment duration was 14 days for ibrutinib and placebo. Adverse events were similar with ibrutinib plus SOC vs placebo plus SOC (overall: 55% vs 50%; serious: 18% vs 13%) and were consistent with the known safety profile of ibrutinib.

Conclusions
Addition of ibrutinib to SOC did not improve the proportion of patients alive and without respiratory failure through day 28 in hospitalized patients with severe COVID-19. Ibrutinib had a manageable safety profile, with similar safety to placebo.

Clinical Trials Registration
NCT04375397.
Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas
Authors: Kennedy Joshua L , Forrest J Craig , Young Sean G , Amick Benjamin , Williams Mark , James Laura , Snowden Jessica , Cardenas Victor M , Boothe Danielle , Kirkpatrick Catherine , Modi Zeel , Caid Katherine , Owens Shana , Kouassi Marianne , Mann Ryan , Putt Claire , Irish-Clardy Katherine , Macechko Michael , Brimberry Ronald K , Nembhard Wendy N , McElfish Pearl A , Du Ruofei , Jin Jing , Zohoori Namvar , Kothari Atul , Hagrass Hoda , Olgaard Ericka , Boehme Karl W 
Published: March 2022

Abstract

Background
The aim of this study was to estimate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rates in the small rural state of Arkansas, using SARS-CoV-2 antibody prevalence as an indicator of infection.

Methods
We collected residual serum samples from adult outpatients seen at hospitals or clinics in Arkansas for non–coronavirus disease 2019 (COVID-19)–related reasons. A total of 5804 samples were identified over 3 time periods: 15 August–5 September 2020 (time period 1), 12 September–24 October 2020 (time period 2), and 7 November–19 December 2020 (time period 3).

Results
The age-, sex-, race-, and ethnicity-standardized SARS-CoV-2 seroprevalence during each period, from 2.6% in time period 1 to 4.1% in time period 2 and 7.4% in time period 3. No statistically significant difference in seroprevalence was found based on age, sex, or residence (urban vs rural). However, we found higher seroprevalence rates in each time period for Hispanics (17.6%, 20.6%, and 23.4%, respectively) and non-Hispanic Blacks (4.8%, 5.4%, and 8.9%, respectively) relative to non-Hispanic Whites (1.1%, 2.6%, and 5.5%, respectively).

Conclusions
Our data imply that the number of Arkansas residents infected with SARS-CoV-2 rose steadily from 2.6% in August to 7.4% in December 2020. There was no statistical difference in seroprevalence between rural and urban locales. Hispanics and Blacks had higher rates of SARS-CoV-2 antibodies than Whites, indicating that SARS-CoV-2 spread disproportionately in racial and ethnic minorities during the first year of the COVID-19 pandemic.
Liquid Biopsy at Home: Delivering Precision Medicine for Patients with Cancer During the COVID-19 Pandemic
Authors: Napolitano Stefania , Caputo Vincenza , Ventriglia Anna , Martini Giulia , Della Corte Carminia Maria , De Falco Vincenzo , Ferretti Stefano , Martinelli Erika , Morgillo Floriana , Ciardiello Davide , De Vita Ferdinando , Orditura Michele , Fasano Morena , Ciardiello Fortunato , Troiani Teresa 
Published: March 2022

Abstract
CoronaVirus disease-2019 has changed the delivery of health care worldwide and the pandemic has challenged oncologists to reorganize cancer care. Recently, progress has been made in the field of precision medicine to provide to patients with cancer the best therapeutic choice for their individual needs. In this context, the Foundation Medicine (FMI)-Liquid@Home project has emerged as a key weapon to deal with the new pandemic situation. FoundationOne Liquid Assay (F1L) is a next-generation sequences-based liquid biopsy service, able to detect 324 molecular alterations and genomic signatures, from May 2020 available at patients’ home (FMI-Liquid@Home). We analyzed time and costs saving for patients with cancer, their caregivers and National Healthcare System (NHS) with FMI-Liquid@Home versus F1L performed at our Department. Different variables have been evaluated. Between May 2020 and August 2021, 218 FMI-Liquid@Home were performed for patients with cancer in Italy. Among these, our Department performed 153 FMI-Liquid@Home with the success rate of 98% (vs. 95% for F1L in the hospital). Time saving for patients and their caregivers was 494.86 and 427.36 hours, respectively, and costs saving was 13 548.70€. Moreover, for working people these savings were 1084.71 hours and 31 239.65€, respectively. In addition, the total gain for the hospital was 163.5 hours and 6785€, whereas for NHS was 1084.71 hours and 51 573.60€, respectively. FMI-Liquid@Home service appears to be useful and convenient allowing time and costs saving for patients, caregivers, and NHS. Born during the COVID-19 pandemic, it could be integrated in oncological daily routine in the future. Therefore, additional studies are needed to better understand the overall gain and how to integrate this service in different countries.
Energy quality and energy grade: concepts, applications and prospects
Authors: Chen Ruihua , Xu Weicong , Deng Shuai , Zhao Li , Zhao Ruikai , Yin Wei , Jiao Ligang , Liu Zhengang 
Published: March 2022

Abstract
A more comprehensive view on the energy properties could contribute to the deepening of thermodynamic theories and efficient utilization of energy, which has both theoretical and practical significance. As derivative concepts of exergy, energy quality and energy grade, which characterize the quality of energy, have been fully applied in the field of engineering thermophysics during the past four decades. However, their concepts and calculations have not been fully clarified, and summaries of related applications are very rare in the literature. This has led to a considerable degree of ambiguity and confusion in the utilization of these concepts, which is not conducive to the application and promotion of the concepts, and would also hinder the process of the cognition for energy properties. Based on literature research, this paper explains the history of the energy quality and energy grade concepts and expands the calculations and related benchmark issues (environmental reference states) in detail. Moreover, in order to better understand the functions of energy quality and energy grade, analysis methods derived from the concepts and their applications are reviewed. Through summarizing existing research, future research needs on energy quality and energy grade is elaborated. This paper will help to clarify the physical meanings and calculations of energy quality and energy grade, as well as contribute to in-depth thinking on the energy quality and energy grade and other potential energy properties.
Extracellular ATP plays an important role in systemic wound response activation
Authors: Myers Ronald J , Fichman Yosef , Stacey Gary , Mittler Ron 
Published: March 2022

AbstractMechanical wounding occurs in plants during biotic or abiotic stresses and is associated with the activation of long-distance signaling pathways that trigger wound responses in systemic tissues. Among the different systemic signals activated by wounding are electric signals, calcium, hydraulic, and reactive oxygen species (ROS) waves. The release of glutamate (Glu) from cells at the wounded tissues was recently proposed to trigger systemic signal transduction pathways via GLU-LIKE RECEPTORs (GLRs). However, the role of another important compound released from cells during wounding (extracellular ATP [eATP]) in triggering systemic responses is not clear. Here, we show in Arabidopsis (Arabidopsis thaliana) that wounding results in the accumulation of nanomolar levels of eATP and that these levels are sufficient to trigger the systemic ROS wave. We further show that the triggering of the ROS wave by eATP during wounding requires the PURINORECEPTOR 2 KINASE (P2K) receptor. Application of eATP to unwounded leaves triggered the ROS wave, and the activation of the ROS wave by wounding or eATP application was suppressed in mutants deficient in P2Ks (e.g. p2k1-3, p2k2, and p2k1-3p2k2). In addition, expression of systemic wound response (SWR) transcripts was suppressed in mutants deficient in P2Ks during wounding. Interestingly, the effect of Glu and eATP application on ROS wave activation was not additive, suggesting that these two compounds function in the same pathway to trigger the ROS wave. Our findings reveal that in addition to sensing Glu via GLRs, eATP sensed by P2Ks plays a key role in the triggering of SWRs in plants.
Deep-seated psychological histories of COVID-19 vaccine hesitance and resistance
Authors: Moffitt Terrie E , Caspi Avshalom , Ambler Antony , Bourassa Kyle , Harrington HonaLee , Hogan Sean , Houts Renate , Ramrakha Sandhya , Wood Stacy L , Poulton Richie 
Published: March 2022

AbstractTo design effective provaccination messaging, it is important to know “where people are coming from”—the personal experiences and long-standing values, motives, lifestyles, preferences, emotional tendencies, and information-processing capacities of people who end up resistant or hesitant toward vaccination. We used prospective data from a 5-decade cohort study, spanning childhood to midlife, to construct comprehensive early-life psychological histories of groups who differed in their vaccine intentions in months just before COVID vaccines became available in their country. Vaccine-resistant and vaccine-hesitant participants had histories of adverse childhood experiences that foster mistrust, longstanding mental-health problems that foster misinterpretation of messaging, and early-emerging personality traits including tendencies toward extreme negative emotions, shutting down mentally under stress, nonconformism, and fatalism about health. Many vaccine-resistant and -hesitant participants had cognitive difficulties in comprehending health information. Findings held after control for socioeconomic origins. Vaccine intentions are not short-term isolated misunderstandings. They are part of a person's style of interpreting information and making decisions that is laid down before secondary school age. Findings suggest ways to tailor vaccine messaging for hesitant and resistant groups. To prepare for future pandemics, education about viruses and vaccines before or during secondary schooling could reduce citizens’ level of uncertainty during a pandemic, and provide people with pre-existing knowledge frameworks that prevent extreme emotional distress reactions and enhance receptivity to health messages. Enhanced medical technology and economic resilience are important for pandemic preparedness, but a prepared public who understands the need to mask, social distance, and vaccinate will also be important.