bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myelodysplastic Syndrome/Acute Myeloid Leukemia Following the Use of Poly-ADP Ribose Polymerase (PARP) Inhibitors: A Real-World Analysis of Postmarketing Surveillance Data
Authors: Zhao Quanfeng , Ma Pan , Fu Peishu , Wang Jiayu , Wang Kejing , Chen Lin , Yang Yang 
Published: June 2022

Background and purpose: poly-ADP ribose polymerase (PARP) inhibitors show impressive efficacy in a range of tumors. However, concerns about rare and fatal adverse events, including myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML) have arisen. The aim of this study was to excavate and evaluate the risk of PARP inhibitors causing MDS and AML based on real-world data from two international pharmacovigilance databases.Methods: We analyzed adverse event (AE) reports of four PARP inhibitors (olaparib, niraparib, rucaparib and talazoparib) associated with MDS and AML from the United States Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) and EudraVigilance (EV) databases between 1 October 2014, and 30 September 2021, including demographic characteristics, fatality and times to onset. Three different data mining algorithms were used to detect the signals of PARP inhibitors associated with MDS and AML.Results: In total, 16,710 and 11,937 PARP inhibitor AE reports were found in the FAERS and EV databases, of which 332 and 349 were associated with MDS and AML, respectively. The median latencies of MDS and AML associated with PARP inhibitors were 211 [interquartile range (IQR) 93.5–491.25] days and 355 (IQR 72.00–483.50) days, respectively. The average fatality rates of MDS and AML caused by the four PARP inhibitors were 39.23 and 45.39%, respectively, in the FAERS database, while those in the EV database were 32.32 and 34.94%, respectively. Based on the criteria used for the three algorithms, a significant disproportionate association was found between PARP inhibitors as a drug class and MDS/AML. Notably, the risk of MDS was much higher than that of AML. Olaparib appeared to have a stronger association with MDS and AML than did other PARP inhibitors.Conclusion: In the real world, PARP inhibitors increase the risk of MDS and AML, which can result in high mortality and tend to occur during long-term use. Our findings provide objective evidence for the postmarketing safety of PARP inhibitors.
The Relationship Between Postgraduates’ Emotional Intelligence and Well-Being: The Chain Mediating Effect of Social Support and Psychological Resilience
Authors: Shuo Zhang , Xuyang Deng , Xin Zhao , Xuebin Cai , Jie Hou 
Published: June 2022

BackgroundPostgraduates usually face more life challenges than undergraduate students, including social, emotional and financial issues, and the prevalence of mental health problems in postgraduates is higher than undergraduates. Therefore, the attention on postgraduates’ mental health status is needed.ObjectivesThe current study explored the relationship between postgraduates’ emotional intelligence and well-being by investigating the mediating effects of social support and psychological resilience and the relationship between them through the construction of a chain mediation model.Method1,228 postgraduates completed the Emotional Intelligence Scale, the Social Support Rate Scale, the Psychological Resilience Scale, and the Subject Well-being Scale.ResultsThere is a chain effect between postgraduates’ social support and psychological resilience mediated by their emotional intelligence and well-being, with a total effect value of 0.049.ConclusionEmotional intelligence has a predictive effect on postgraduates’ well-being. The mechanism of this effect includes the indirect effects of social support and psychological resilience. Study results revealed the relationship mechanism between emotional intelligence and postgraduates’ well-being, and provide reference for explorations of how to development postgraduates’ emotional intelligence and further improving their abilities to strengthen their emotional resilience.
Educational Gradients Behind Medical Adverse Event Deaths in the US—A Time Series Analysis of Nationwide Mortality Data 2010–2019
Authors: Oura Petteri 
Published: June 2022

BackgroundDeaths due to medical care appear common. Individuals with low socioeconomic position seem to be at a higher risk for sustaining a medical adverse event and premature death. This time series analysis aimed to assess educational gradients behind adverse event deaths in the US over the period 2010–2019.MethodsPublicly available mortality and census data were retrieved from official sources. The data included age, sex, educational attainment, and underlying cause of death. Adverse event deaths were identified by ICD-10 codes Y40—Y84 and Y88. Four education categories were created in accordance with the International Standard Classification of Education 2011 coding scheme [No high school or General Educational Development (GED); High school or GED; Some college; Bachelor's degeree or higher]. To capture also highly educated individuals, the analysis was delimited to ≥30-year-olds. Age-adjusted mortality rates (AMRs) were compared between education categories by means of mortality plots and linear mixed models.ResultsA total of 25,897,334 certified deaths occurred among ≥30-year-olds during the study period. The underlying cause of death was an adverse event in a rarity of cases (0.12%, n = 31,997). Individuals with Bachelor's degeree or higher had the lowest adverse event AMRs (6.1–12.4 per million per year), followed by the Some college category (9.6–18.6), the High school or GED category (17.1–35.4), and finally the No high school or GED category (20.0–36.0). AMRs showed a gradual increase as education level decreased (p ≤ 0.001 against those with Bachelor's degeree or higher). Moreover, the temporal increase in adverse event AMRs was more pronounced among individuals with low than high education; the contrasts between categories were greatest toward the end of the study period.ConclusionThe findings of this study suggest that the widening socioeconomic gradients in mortality extend also to fatal adverse events. Future studies should aim to analyze whether access to care, severity of the condition at presentation, quality of care, and social determinants of health may drive the gradients.
Starting Time of Presbyopic Eyeglasses Wear and Lifestyle
Authors: Ayaki Masahiko , Negishi Kazuno , Kawashima Motoko , Tsubota Kazuo 
Published: June 2022

PurposePresbyopia is a serious burden in the aged population, however, the factors affecting its progression have not been fully determined. The aim of this study was to explore the association between the time of starting to wear presbyopic eyeglasses and lifestyle, in participants aged from 40 to 59 years.MethodsWe selected the sample to be representative of sex and age for the age group 40 to 59 years. Participants completed a web-based survey on presbyopia-related questions, symptomatic dry eye, sleep habits, Pittsburgh Sleep Quality Index, subjective happiness scale (SHS), and other lifestyle-related questions including marital status, income, screen time, sun exposure, family history of myopia, and the frequency of regular visits to medical services.ResultsWe found 529 participants (26.5%) used near correction, with a mean age for first near correction of 47.8±4.8 years. An earlier commencement of near correction correlated with hyperopia (P = 0.013), late wake-up time (P = 0.010), a poor subjective sleep quality score (P = 0.019), and a low annual income score (P = 0.025), after adjusting for age and sex. Stratification by income demonstrated the low-income group exhibited more dry eye, later wake-up time, longer sleep latency, longer sleep duration, worse sleep efficacy, lower SHS score, and a higher prevalence of living alone compared with the high-income group. The usage of corrective devices did not differ between the two groups.ConclusionsThe current study suggests a healthy sleep habit may delay the need for near correction, in addition to myopia. Shift work and circadian rhythm disruption might exacerbate presbyopia progression.
The State of Public Health Education and Science During and After the Fall of the Soviet Union: Achievements, Remaining Challenges, and Future Priorities
Authors: Gotsadze George , Mirzikashvili Nino , Kekelidze Dali , Kalandarishvili Sopio , Kalandadze Iagor , Abiatari Ivane , Zoidze Akaki 
Published: June 2022

ObjectivesIn the post–COVID-19 world, when the adequacy of public health workforce education is being critically re-evaluated, this study undertakes a historical analysis of how the educational and scientific field of public health developed during and after the fall of the Soviet Union in 1991. The study intends to historically contextualize public health education and science development in former Soviet Republics. It attempts to document achievements after gaining independence and identify remaining challenges that need to be addressed for advancing public health science and education in Former Soviet Union countries to better prepare them for future pandemics and address current health challenges of the nations.MethodsThe study used a mixed-methods review approach combining both a literature review, information collection from the school's websites, and secondary analysis of the quantitative data available about scientific outputs—peer-reviewed articles.ResultsDuring communist rule and after the fall of the Soviet Union, the main historical events seem to have shaped the public health field of former Soviet countries, which also determined its eventual evolution. The international efforts post-1991 were instrumental in shifting medically oriented conceptualization of public health toward Western approaches, albeit with variable progress. Also, while scientific output has been growing from 1996 to 2019, sub-regional differences remain prominent.ConclusionThe region seems to have matured enough that it might be time to start and facilitate regional cooperation of public health schools to advance the field of public health and research. Regional and country variabilities feature prominently in the volume and quality of scientific output and call for the immediate attention of national governments and international partners.
Burden and Predictors of Malnutrition Among Indian Adolescents (10–19 Years): Insights From Comprehensive National Nutrition Survey Data
Authors: Pandurangi Raghavendra , Mummadi Mahesh Kumar , Challa Sairam , Reddy N. Samarasimha , Kaliaperumal Venkatesh , Khadar Babu Chinta , Telikicherla Usha Rani , Pullakandham Raghu , Geddam J. J. Babu , Hemalatha Rajkumar 
Published: June 2022

Introduction:Malnutrition among adolescents is a persistent problem with a profound impact on different dimensions of health. The objective of this analysis is to assess the burden of malnutrition (Stunting, Thinness, Overweight, and Obesity) and their associated socio-demographic factors among Indian adolescents (10–19 years) from the Comprehensive National Nutritional Survey (CNNS 2016-18) data.MethodsWe used Individual-level data of 35,831 adolescents from the CNNS conducted in 2016–18 for this analysis. CNNS collected data on the nutritional status of adolescents along with socio-demographic variables from all states of India. Burden of stunting (Height for age Z score, HAZ &lt; −2 SD), thinness (BMI for age Z score, BAZ &lt; −2 SD), overweight (BAZ &gt; 1 SD) and obesity (BAZ &gt; 2 SD) were estimated for the entire country and individual states. A multivariable logistic regression analysis was used to assess the socio-demographic factors associated with stunting, thinness, and overweight.ResultsCNNS collected data from 35,831 adolescents, of which 31,941 with BAZ scores, and 32,045 with HAZ scores were included in the final analysis. The burden of stunting and thinness among Indian adolescents was 27.4% (95% CI 26.4, 28.4%) and 24.4% (23.5, 25.4%), respectively. The burden of overweight and obesity was 4.8% (4.5, 5.1%) and 1.1% (0.9, 1.3%), respectively. Adolescents in the age group of 15–19 years (AOR 1.23, 95% CI 1.11, 1.36) compared to 10–14 years, females (AOR 1.20; 1.08, 1.33) compared to males, were at increased odds of getting stunted. Adolescents from lowest wealth index families (AOR 1.66; 1.33, 2.07) were at increased odds of thinness compared to peers of higher wealth index families. Adolescents of 10–14 years (AOR 1.26, 95% CI 1.06, 1.49) compared to 15–19 years, urban residents (AOR 1.43, 95% CI 1.19, 1.71) compared to rural residents, were at increased odds of overweight.ConclusionIndian adolescents face the double burden of malnutrition that is undernutrition (stunting and thinness) alongside overnutrition (overweight and obesity) that are linked with socio-demographic factors. The National Nutritional Programs (POSHAN Abhiyan) should prioritize high-risk groups specifically older age group (15–19 years), females, and low wealth Index quintile families identified in this analysis.
The Role of Dihydroresveratrol in Enhancing the Synergistic Effect of
Ligilactobacillus salivarius
Li01 and Resveratrol in Ameliorating Colitis in Mice
Authors: Fei Yiqiu , Zhang Shuobo , Han Shengyi , Qiu Bo , Lu Yanmeng , Huang Weixing , Li Fang , Chen Deying , Berglund Björn , Xiao Hang , Li Lanjuan , Yao Mingfei 
Published: June 2022

Currently approved therapeutical strategies for inflammatory bowel diseases (IBD) suffer from variable efficacy and association with risk of serious side effects. Therefore, efforts have been made in searching for alternative therapeutics strategies utilizing gut microbiota manipulation. In this study, we show that the probiotic strain
Ligilactobacillus salivarius
Li01 (Li01) and the phytochemical prebiotic resveratrol (RSV) have synergistic effect in ameliorating colitis in mice. Oral coadministration of Li01 (10
9
CFU/d) and RSV (1.5 g/kg/d) promoted restoration of various inflammatory injuries and gut microbiota composition, exhibiting a favorable anti-inflammatory effect in DSS-induced colitis mice. The combination treatment was associated with reductions in the levels of proinflammatory cytokines IL-1
β
and IL-6 and increases in the levels of the anti-inflammatory cytokine IL-17A in mouse serum. Moreover, the combination treatment was found to alter the composition and metabolism of the gut microbiota, especially influencing the production of short chain fatty acids and anti-inflammatory related molecules. The mechanism underlying the improved anti-inflammatory effect from the RSV and Li01 combination treatment was found to be associated with the environmental sensor mammalian aryl hydrocarbon receptor (AHR) and tryptophan metabolism pathway. Administration of RSV in combination with Li01 in different mouse model led to enhanced conversion of RSV into metabolites, including dihydroresveratrol (DHR), resveratrol-sulfate, and resveratrol-glucuronide. DHR was found to be the dominant metabolite of RSV in conventional and colitis mice. An increased DHR/RSV ratio was confirmed to activate AHR and contribute to an enhanced anti-inflammatory effect. DHR is considered as a potential AHR ligand. The DHR/RSV ratio also affected the serotonin pathway by controlling the expression of Tph1, SERT, and 5-HT
7
R leading to amelioration of colitis in mice. Our data suggest that treatment with a combination of Li01 and RSV has potential as a therapeutic strategy for IBD; further investigation of this combination in clinical settings is warranted.
Implementasi MAC Address Register Untuk Mengatasi Pengguna Anonim Dalam Jaringan
Authors: Pramudya Pahala Bima , D Djuniadi 
Published: June 2022

Keamanan adalah faktor penting di era digital saat ini. Privasi data dan kelancaran beraktivitas merupakan hal yang sangat membutuhkan keamanan. Penerapan sistem keamanan dalam suatu jaringa merupakan fokus utama seorang developer jaringan dan administrator jaringan. Keamanan jaringan terdapat berbagai macam metode dengan fungsi yang berbeda-beda untuk mengatasi bermacam ancaman. Salah satu keamanan jaringan yang paling dasar adalah berupa hak akses. Penerapan MAC Adress Register sebagai keamanan dasar yang dapat mencegah Pengguna Anonim mengakses sistem jaringan. Langkah dasar yang digunakan berupa memanajemen akses untuk masuk ke dalam jaringan dengan identifikasi data user. MAC Address merupakan identitas device yang unik. Tujuan dari studi ini untuk melakukan simulasi keamanan jaringan menggunakan Cisco Packet Tracer dengan metode MAC Address Register. Hasil yang didapatkan dari simulasi adalah sistem yang mampu mencegah Pengguna Anonim untuk mengakses jaringan, dan mengizinkan pengguna dengan MAC Address registered untuk mengakses jaringan.
HUBUNGAN ANTARA REGULASI DIRI DAN RESILIENSI DALAM MENGERJAKAN SKRIPSI PADA MAHASISWA PROGRAM STUDI PENDIDIKAN AGAMA ISLAM DI INSTITUT AGAMA ISLAM IBRAHIMY BANYUWANGI
Authors: Fathoni Moh. Hadi , Alwi Muhib 
Published: June 2022

Penelitian ini bertujuan untuk memahami tingkat regulasi diri mahasiswa, tingkat resiliensi mahasiswa dan untuk memahami hubungan antara regulasi diri dn resiliensi mahasiswa yang sedang mengerjakan skripsi di IAII Banyuwangi.
Fokus masalah pada skripsi ini adalah: 1) Bagaimana tingkat regulasi diri mahasiswa yang sedang mengerjakan skripsi di IAII Banyuwangi? 2) Bagaimana tingkat resiliensi mahasiswa yang sedang mengerjakan skripsi di IAII Banyuwangi? 3) Adakah hubungan antara regulasi diri dengan resiliensi terhadap mahasiswa yang sedang mengerjakan skripsi di IAII Banyuwangi
Tujuan dari skripsi ini adalah: 1) untuk memahami tingkat regulasi diri mahasiswa yng sedang mengerjakan skripsi di IAII Banyuwangi. 2) untuk memahami tingkat resiliensi mahasiswa yang sedang mengerjakan skripsi di IAII Banyuwangi. 3) Mengidentifikasikan hubungan regulasi diri dengan resiliensi terhadap mahasiswa yang sedang mengerjakan skripsi di IAII Banyuwangi.
Untuk mengidentifikasi permasalahan tersebut, Jenis penelitian yang digunakan dalam skripsi ini menggunakan metode penelitian kuantitatif, dengan jumlah populasi mahasiswa IAII Banyuwangi sebanyak 136 orang dan sampel yng digunakan sebanyak 25% yakni 36 orang. Data dalam penelitian ini diperoleh dengan menggunakan skala regulasi diri dan resiliensi.
Penelitian ini memperoleh kesimpulan. 1) Tingkat Regulasi Diri pada mahasiswa fakultas Tarbiyah IAI Ibrahimy genteng banyuwangi berada pada kategori kuat dengan persentase mencapai 91,7%. 2) Tingkat Resiliensi pada mahasiswa yang sedang mengerjakan skripsi pada mahasiswa fakultas Tarbiyah IAI Ibrahimy genteng banyuwangi berada pada kategori sangat lemah dengan persentase mencapai 74,6%. 3) Terdapat hubungan yang positif antara regulasi diri dengan resiliensi. Semakin tinggi regulasi diri yang dimiliki seorang mahasiswa maka semakin tinggi tingkat resiliensi, sebaliknya semakin rendah regulasi diri mahasiswa maka semakin rendah pula tingkat resiliensi.
Study of transient characteristics of BAW filters under high power levels
Authors: Fan Yang , Ge Wang 
Published: June 2022

Abstract
The improvement of power capacity would benefit greatly from the analysis of transient characteristics of bulk acoustic wave (BAW) devices. For this purpose, a measurement system was established, which could capture the temperatures and the insertion loss (IL) of the BAW devices simultaneously. Based on the obtained testing data of four different commercial BAW filters, we clarified the time dependence of device temperature and IL. The results showed that the BAW filters would exhibit higher power capacity with higher threshold frequency and a lower slope of the characteristic curves. This prompts us to propose an evaluation method for BAW filters under high power levels, which could improve the efficiency of device selection and performance prediction.
Effectiveness of instructional program on parents' knowledge toward dietary patterns for children with picky eating behavior at Al-Zahra Teaching Hospital in Al-Najaf Al-Ashraf City
Authors: Shaker Wameedh , AL-Mosawi Khatam M. 
Published: June 2022

Abstract
Objective: Assess parents' knowledge up on dietary patterns for children with picky eating behavior before providing instructional program. Methodology: To achieve the aims of this study, this quasi-experimental design was conducted on children suffering from picky eating behavior assigned to study and control groups is used to study the effectiveness of instructional program on parents' knowledge toward dietary patterns for children with picky eating behavior at Al-Zahra Teaching Hospital. Questionnaires were developed to determine the effectiveness of the instructional program on parents' knowledge toward dietary patterns for children with picky eating behavior. The final instruments consisted of (4) parts First: concept of picky eating behavior in children (Includes four questions) Second: causes of picky behavior and dangerous factors (Includes eight questions) Third: symptoms of picky behavior (includes six questions) Fourth: importance of a child's picky eating behavior diet (consists of seven questions) Fifth: ways to deal with the child picky eating behavior in food (contains seven questions) Sixth: therapeutic and guiding measures for picky eating children (has thirteen questions). Result: there is a non-significant difference in the study sample knowledge according to their residency, gender, child's age/years, and child's order in the family. Conclusion: Parents in the study group who received the dietary instructional program different views and experiences on overall behaviors and attitudes about mealtime and daily food, demonstrating that the dietary instruction had a positive impact on child behavior. Recommendation: Develop techniques to influence children's eating and general lifestyle habits while taking into consideration the environment and their family.