bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rectal Administration of Celecoxib Liquid Suppositories with Enhanced
Bioavailability and Safety in Rats
Authors: Xie Shijing , Jiao Yan , Baseer Abdul , Ud-din Fakhar 
Published: May 2022

Background:
Celecoxib is generally used for the treatment of rheumatoid arthritis, however
its poor bioavailability and cytotoxicity in pure form have reduced its therapeutic efficacy. This study
aims to develop celecoxib liquid suppositories with improved bioavailability and reduced toxicity.

Methods:
The celecoxib liquid suppositories were prepared by thoroughly mixing celecoxib, poloxamer
188 and poloxamer 407, and tween-20, respectively used as drug, polymers and surfactant, in triple
distilled water using cold technique. The developed liquid suppositories were characterized in terms of
their gelation temperature, gelation time, and gel strength. Moreover, the muco-adhesive force was
determined for the suppositories. The release behavior of the liquid suppositories was investigated in
distilled water and compared with drug suspension. Furthermore, pharmacokinetics and morphological
studies were carried out in rats after rectal administration of the celecoxib liquid suppository compared
with drug suspension.

Results:
Poloxamer 188 and Tween-20 concentrations have significantly reduced the gelation temperature
and time; however, the gel strength and bio-adhesive force were significantly enhanced. The concentration
of celecoxib has no significant effect on the properties of liquid suppositories. A significantly
enhanced and potentially sustained drug release was observed from the celecoxib liquid suppositories as
compared with the drug suspension. The optimized formulation was easy to administer rectally because
it quickly forms gel upon insertion into the body due to a suitable gelation temperature of about
31.7 °C. After rectal administration in rats, the celecoxib liquid suppository gave a significantly increased
pharmacokinetic profile including enhanced plasma concentration and 9.7 fold improved area
under the curve (AUC) compared to the drug suspension. Additionally, the morphology study exhibited
no toxicity to the rectal tissue, no signs of irritation, or injury after the application of suppository. However,
severe rectal tissue toxicity and irritation was observed in the suspension treated rectum.

Conclusions:
It can be concluded that the liquid suppository system may significantly enhance the solubilization
and bio-availability of sparingly water-soluble drugs as evident in the case of celecoxib with
no toxicity at the site of application.
Angiotensin-Converting Enzyme Inhibition Properties and Antioxidant
Effects of Plants and their Bioactive Compounds as Cardioprotective
Agent
Authors: Qidwai Tabish , Prasad Sonal 
Published: May 2022

Background:
The prevalence of cardiovascular diseases is being increased; researchers are
trying to explore effective preventive and treatment options. Antioxidant effects and AngiotensinConverting
Enzyme (ACE) inhibitors demonstrated cardioprotective effects. Many herbs and plants have shown antiinflammatory, antioxidant, free radical scavenging, and ACE inhibition properties in preventing and treating cardiac-related disorders. Therefore, the exploration of bioactive compounds such as polyphenols,
flavonoids, quercetin, kaempferol, isoflavones, and catechin needs to be explored as potential ACE inhibitors and antioxidants in preventing and treating cardiac-related diseases

Objective:
The present study is designed to investigate the cardio-protective potential of important bioactive compounds from plants and herbs.

Methods:
Articles were collected from electronic databases, such as PubMed, Google Scholar, Web of
Science, and Science Direct, using the keywords antioxidant, anti-inflammatory, ACE inhibition and antihypertensive properties of plants and herbs. In vitro and in vivo studies on animal models have been included in the current study. Articles published in languages other than the English language were excluded, and finally, 100 manuscripts were included in this study.

Results:
Plants and herbs chosen for this study with abundant natural bioactive compounds have demonstrated ACE inhibition, antioxidant, anti-inflammatory, and anti-hypertensive properties and can be an
effective cardioprotective. Hence, it could pave the way for the development of new therapeutics that
could be beneficial in treating cardiovascular diseases

Conclusion:
The current review focuses on herbs and plants possessing ACE inhibition, antioxidant, antioxidative, anti-inflammatory, hyperaccumulating and anti-hypertensive properties with their ability to
prevent the breakdown of ACE I enzyme into ACE enzyme II, acting as ACE inhibitors and showing its
strong potential as a cardioprotective agent. Also, it could support the development of new therapeutic
agents to address cardiovascular problems.
Treatment with Cannabidiol Results in an Antioxidant and Cardioprotective
Effect in Several Pathophysiologies
Authors: do Vale Gabriel T. , Oliveira Natasha M.C. , Machado Dayane A. , da Silva Thauann L. 
Published: May 2022

Abstract:
Cannabis sativa has chemically active compounds called cannabinoids, where Δ9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) are the main ones responsible for the various pharmacological effects. The endocannabinoid system is an endogenous system considered a unique and widespread homeostatic physiological regulator. It is made up of type 1 (CB1) and type 2 (CB2) cannabinoid receptors. CBD, in turn, has low affinity for CB1 and CB2 receptors, and regulates the effects arising from THC as a CB1 partial agonist, which are tachycardia, anxiety and sedation. It also acts as a CB2 inverse agonist, resulting in anti-inflammatory effects. Furthermore, its anticonvulsant, neuroprotective, antipsychotic, antiemetic, anxiolytic, anticancer and antioxidant effects seem to be linked to other discovered receptors such as GRP55, 5TH1a, TRPV I, TRPV II and the regulation of the intracellular concentration of Ca2+. Regarding oxidative stress, O2- can act as an oxidizing agent, being reduced to hydrogen peroxide (H2O2), or as a reducing agent, donating its extra electron to NO to form peroxynitrite (ONOO-). The ONOO- formed is capable of oxidizing proteins, lipids, and nucleic acids, causing several cell damages. In this sense, CBD can prevent cardiac oxidative damage in many conditions, such as hypertension, diabetes, or even through the cardiotoxic effects induced by chemotherapy, which makes it a potential target for future clinical use to minimize the deleterious effects of many pathophysiologies.
Preparation of Bismuth Tungstate/Preoxidized Acrylonitrile/Acrylic Acid
Copolymer Composite Nanofiber Membrane and Its Photocatalytic
Properties
Authors: Fang Yinchun , Liu Xinhua , Li Hongzhang , Liu Yanchun 
Published: May 2022

Background:
In this paper, a novel bismuth tungstate/preoxidized acrylonitrile/acrylic acid
(AN/AA) copolymer composite nanofiber membrane was prepared, which was used as the visible light
catalyst.

Methods:
AN/AA copolymer was synthesized, which was electrospun with bismuth nitrate and sodium
tungstate to prepare the composite nanofiber. Then the composite nanofiber was preoxidized to prepare
the bismuth tungstate/preoxidized AN/AA composite nanofiber membrane containing adsorption moiety
and photocatalytic active moiety.

Results:
The photocatalytic activity of bismuth tungstate/preoxidized AN/AA composite nanofiber
membrane with different preoxidized temperature, heating rate, and holding time by catalytic degradation
of methylene blue was investigated. The optimal preoxidized conditions were as follows: the preoxidized
temperature was heated to 200 °C with the heating rate of 1°C/min and the holding time at
this temperature was 12 h. The chemical structure and morphology of the composite nanofiber membrane
were characterized by FTIR, XRD, and SEM.

Conclusions:
The bismuth tungstate/preoxidized AN/AA composite nanofiber membrane obtained good
photocatalytic properties and reusability under visible light. The degradation rate of methylene blue by
this visible light catalyst could reach 90.24% for 4.5 h, and the degradation rate remained 81.53% for
4.5 h after 5 reuses.
Deep Image Segmentation Using a Morphological Edge Operator
Authors: Zhang Mei , Xu Bin , Wen Jinghua 
Published: May 2022

Background:
Segmentation of deep images is a difficult, persistent problem in the
computer vision field. This paper aimed to address the defects of traditional segmentation
methods with deep images, presenting a deep image segmentation algorithm based on a
morphological edge operator.

Methods:
Deep image edge features were first extracted using three traditional edge operators;
the edge and tip type jump edges were then extracted via a morphological edge operator, which
was used to make the boundary connection; finally, to obtain more accurate segmentation results,
skeletonizing was used to refine the image.

Results:
Compared with traditional segmentation algorithms, the improved algorithm obtained
smooth and continuous boundaries, protected edge information from blurring, and was slightly
more efficient. When Mickey Mouse depth images were used as experimental subjects, the
computational time was reduced by 12.62 seconds; when rabbit depth images were used,
computational time was reduced by 17.53 seconds.

Conclusion:
Morphological edge operator algorithm proposed in this paper is much more
effective than traditional edge detection operators algorithms for deep image segmentation; it can
clearly divide Mickey Mouse's ears, eyes, pupils, nose, and mouth.
Correlaciones y análisis de sendero entre características del fruto y la semilla de Benincasa hispida [(Thunb.) Cogn.]
Authors: Espitia Camacho Miguel M. , Araméndiz Tatis Hermes , Cardona Ayala Carlos E. 
Published: May 2022

Las correlaciones y el análisis de sendero son estrategias importantes para mejorar la selección de características agronómicas de interés comercial en diversos cultivos. El objetivo de este trabajo fue estimar las correlaciones entre 14 características biométricas del fruto y la semilla, y el análisis de sendero para el peso del fruto en B. hispida. Se evaluaron 10 familias de hermanos medios, en un diseño completamente aleatorizado con cinco repeticiones. El peso del fruto mostró correlaciones fenotípicas significativas directas con grosor de la pulpa, largo del fruto, ancho del fruto, número de semillas, cavidad semilla y peso de semillas, cuyos coeficientes oscilaron entre 0,64* y 0,91**, respectivamente. El largo de semilla presentó asociación directa significativa con volumen de una semilla y el peso de una semilla, con registros de 0,66* y 0,83**, respectivamente. El ancho de semilla y el volumen de una semilla acusaron correlación de 0,88**, mientras que la densidad de una semilla presentó correlación inversa significativa con el ancho de semilla y el volumen de una semilla, con registros de -0,73* y -0,89**. Los efectos indirectos explicaron principalmente la correlación significativa del peso del fruto con las variables ancho del fruto, cavidad semilla, peso de semillas y número de semillas. El largo del fruto presentó los mayores efectos directos e indirectos sobre el peso del fruto. El peso del fruto y largo del fruto, pueden ser usados en la selección de B. hispida para la obtención de genotipos con mayor peso y número de semillas por fruto.
Understanding Whole-Person Health and Resilience During the COVID-19 Pandemic and Beyond: A Cross-sectional and Descriptive Correlation Study
Authors: Rajamani Sripriya , Austin Robin , Geiger-Simpson Elena , Jantraporn Ratchada , Park Suhyun , Monsen Karen A 
Published: May 2022

Background
The COVID-19 pandemic has prompted an interest in whole-person health and emotional well-being. Informatics solutions through user-friendly tools such as mobile health apps offer immense value. Prior research developed a consumer-facing app MyStrengths + MyHealth using Simplified Omaha System Terms (SOST) to assess whole-person health. The MyStrengths + MyHealth app assesses strengths, challenges, and needs (SCN) for 42 concepts across four domains (My Living, My Mind and Networks, My Body, My Self-care; eg, Income, Emotions, Pain, and Nutrition, respectively). Given that emotional well-being was a predominant concern during the COVID-19 pandemic, we sought to understand whole-person health for participants with/without Emotions challenges.

Objective
This study aims to use visualization techniques and data from attendees at a Midwest state fair to examine SCN overall and by groups with/without Emotions challenges, and to explore the resilience of participants.

Methods
This cross-sectional and descriptive correlational study surveyed adult attendees at a 2021 Midwest state fair. Data were visualized using Excel and analyzed using descriptive and inferential statistics using SPSS.

Results
The study participants (N=182) were primarily female (n=123, 67.6%), aged ≥45 years (n=112, 61.5%), White (n=154, 84.6%), and non-Hispanic (n=177, 97.3%). Compared to those without Emotions challenges, those with Emotions challenges were aged 18-44 (P<.001) years, more often female (P=.02), and not married (P=.01). Overall, participants had more strengths (mean 28.6, SD 10.5) than challenges (mean 12, SD 7.5) and needs (mean 4.2, SD 7.5). The most frequent needs were in Emotions, Nutrition, Income, Sleeping, and Exercising. Compared to those without Emotions challenges, those with Emotions challenges had fewer strengths (P<.001), more challenges (P<.001), and more needs (P<.001), along with fewer strengths for Emotions (P<.001) and for the cluster of health-related behaviors domain concepts, Sleeping (P=.002), Nutrition (P<.001), and Exercising (P<.001). Resilience was operationalized as correlations among strengths for SOST concepts and visualized for participants with/without an Emotions challenge. Those without Emotions challenges had more positive strengths correlations across multiple concepts/domains.

Conclusions
This survey study explored a large community-generated data set to understand whole-person health and showed between-group differences in SCN and resilience for participants with/without Emotions challenges. It contributes to the literature regarding an app-aided and data-driven approach to whole-person health and resilience. This research demonstrates the power of health informatics and provides researchers with a data-driven methodology for additional studies to build evidence on whole-person health and resilience.
Demographic evaluation of Post-Concussion Syndrome in referrals to Bandar Abbas Forensic Medical Center, South of Iran from March 2020 to August 2021
Authors: Mohammadi Saeed , Mirhadi Seyed Javad , Javadi Vasigh Hosein , Asadi Khatere , Memarian Azadeh , Nikkhah Farahnaz 
Published: May 2022

Objectives: The aim of the present study is the demographicassessment of PCS in referrals to forensic medical centersin Bandar Abbas.
Methods: This cross-sectional and descriptive study was performed on 72 patients with mild brain trauma who were referred to Bandar Abbas forensic medical center. PCS was confirmed according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. Information on age, sex, mechanism of trauma, the time interval between the first visit to the forensic medical center, level of consciousness, number of hospitals stays days, number of days in ICU, and symptoms at initial referral were recorded in the designed form.
Results: The mean age of patients was 30.81 Â± 13.39 years. There was a significant difference in sex and mechanisms of trauma (P < 0.001). The average time interval of the first referral to forensic medical center was 9.44 Â± 18.37 days.87.5% were hospitalized and only 9.7% were hospitalized at ICU. The consciousness level of all patients was in the range of 12 to 15 (mild range).Among symptoms, headache (87.5%) and dizziness (81.9%) were the most significant prevalent symptoms. 70.8% of patients had no symptoms one month after the accident but 12.5% still had symptoms and only 9.7% still had symptoms of concussion after3 months.
Conclusion: According to the results, PCS mostly happened in the male gender and the main mechanism of trauma was an accident. Headache and dizziness were the main symptoms. Only a small percentage of patients have symptoms after one month and three months, post-injury.
Safety and efficacy of COVID-19 Vaccines in special populations
Authors: Alattas Sana , Ibrahim Ibrahim M , Ali Ahmed S. , Barakat Jehan M , A Shaker Assmaa , Momen Tasneem N , S. Mohamed Abir , Alfadil Abdalbabgi , Alharbi Amani E 
Published: May 2022

Coronavirus disease 2019 (COVID-19), is a pandemic that resulted in extreme human and economic losses. A higher incidence of morbidity and mortality to COVID-19 was demonstrated in a special population. Factors that impact the disease severity include old age, obesity, pregnancy, diabetes mellitus, cancer, and immunosuppressive drugs. Fortunately, several COVID-19 vaccines were developed such as Pfizer-BioNTech, Moderna, Oxford-AstraZeneca, and Johnson & Johnson among others. These vaccines have shown good efficacy and safety profiles in the general population, but serious rare adverse effects were reported related to specific vaccines. Several studies are undergoing to test the efficacy in special populations. Reduced efficacy or delayed immunological response to COVID-19 vaccines were suggested for patients with autoimmune disorders or organ transplant patients, especially those receiving certain medications such as rituximab. There is a concern about organ rejection in organ transplant patients. Despite these facts, there is an agreement among health care providers to consider prioritization of the above-mentioned groups for receiving vaccinations with the same precautions followed for the general population. It is recommended to ongoing studies determine the efficacy and safety of COVID-19 vaccines in patients with comorbidities based on clinical data.
The Beginnings of a Theology of Luke—Acts: Divine Activity and Human Response
Authors: Jipp Joshua W. 
Published: May 2022

ABSTRACT
Whereas NT theology has been the subject of a large amount of sophisticated analysis, the lack of methodological reflection regarding what it means to speak of the theology of a distinct NT text is surprising, especially given that the task is foundational, one would suppose, for the larger project. One should begin, then, by asking the methodological question: what does it mean to speak of a theology of a distinct NT text? Related, what is theology, and how does it, or how should it, determine the task of writing a theology of Luke–Acts? What sets apart a theology of Luke–Acts from, say, a literary analysis, a motif-oriented study, or a historiographical examination? And what is the relationship between theology and genre, in this instance, theology and narrative? My basic claim is that a "theology of Luke–Acts" should render the kerygmatic intention of Luke in such a way so as to explicate the epistemological, existential, and theological claims that Luke's narrative makes on the reader. The subject of Luke–Acts is the living God as revealed in Jesus Christ and, as Acts would have us affirm, within his church. Therefore, to speak of a theology of Luke–Acts presumes that God's presence is truly experienced within the lives of his people through these writings. A theology of a NT composition, then, should include both rigorous historical and literary attention to the text as well as attention to the way the biblical text elicits human faith, knowledge of God, and humanity's relation to God.
"Nothing beyond What Is Written"? 1 Corinthians and the Hermeneutics of Early Christian "Theologia"
Authors: Starling David I. 
Published: May 2022

ABSTRACT
A recent flurry of discussion among evangelical theologians and interpreters of Scripture has explored the question of whether, and in what manner, we ought to go "beyond the Bible" in doing systematic theology. In this article, I examine several of Paul's forays into the conversations that would have counted as theologia in the Greco-Roman world of early Christianity, with the aim of shedding some Pauline light on the question of how we might make a faithful movement from Scripture to theology.
What Do I Fear When I Fear My God? A Theological Reexamination of a Biblical Theme
Authors: Fout Jason A. 
Published: May 2022

ABSTRACTS
Many commonly misunderstand "the fear of God" as a biblical trope. Systematic and constructive theologians have often left it unexamined; biblical theologians have explicated it from one of three perspectives: either as a response to "the Holy" (drawing on Rudolf Otto), as a human emotional reaction to God, or as human obedience to God. This essay argues against the first two options and for the third as the best understanding of the scriptural term and does so on the basis of theological exploration of the Torah and the Gospel of Matthew. The account concludes that fear of God is a human disposition encouraged, learned, and grown within the covenant people of God. Fear of God might be summarized therefore as an appropriate relational disposition toward God, involving obedience to God above all others; furthermore, this obedience to God implies being just and loving toward others. Fear of God does not paralyze or overwhelm the human creature but is the basis for proper human acting and thinking. This disposition of fearing God leads to human flourishing, but sees this human flourishing as genuine only when understood against the greater horizon of meaning that is God and God's kingdom. Thus fear of God, far from being the hiatus of human agency, is the form of sociality given by God for humanity.
Bible and Church, Bultmann and Augustine: A Response to David Congdon
Authors: Moberly R. W. L. 
Published: May 2022

ABSTRACTS
I respond here to Congdon's 2014 response to my 2012 essay on Bultmann and Augustine. I argue that although Congdon offers a useful account of Bultmann's theology and ecclesiology on its own terms, he does not sufficiently relate this to the question of the relationship between biblical interpretation, ecclesiology, and the social nature of knowledge, which I find to be well articulated by Augustine. I critique Bultmann's application of justification by faith alone to epistemology, which seems to underlie his reticence about the possible epistemological significance of ecclesiology. And I suggest that Bultmann's program for theological interpretation, although it has enduring depth and challenge, is nonetheless significantly limited as a resource for contemporary theological interpretation.
Prophetic Representations of the Divine Presence: The Theological Interpretation of the Elijah-Elisha Cycles
Authors: Lunn Nicholas P. 
Published: May 2022

ABSTRACTS
The narratives concerning Elijah and Elisha contain a number of unique elements, the most evident of which is the miracles they performed, without parallel among the other prophets. This article focuses on a further uniqueness hitherto undetected in scholarly research. Many of the episodes involving Elijah and Elisha include language relating either to the Hebrew sanctuaries, namely, the tabernacle and temple, or to theophanies. These two are conceptually associated in that both serve as representations of the divine presence. Allusions to the ritual and furniture of the sanctuary, as well as theophanic elements centering on the prophets, are taken as deliberate literary devices intended to communicate a message to the people of Israel. The latter part of this article discusses the theological import of this message, primarily within its immediate historical context, but also within the larger canonical framework.