bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-Silico Designing of a Multi-Epitope Vaccine against SARS-CoV2 and
Studying the Interaction of the Vaccine with Alpha, Beta, Delta and Omicron
Variants of Concern
Authors: Paul Santanu , Pal Aranya , Pyne Nibedita 
Published: September 2022

Background:
The sudden appearance of the SARS-CoV2 virus has almost changed the future
of vaccine development. There have been many different approaches to vaccination; among them,
computational vaccinology in the form of multi-epitope vaccines with excellent immunological properties
and minimal contamination or other adverse reactions has emerged as a promising strategy with
a lot of room for further study in this area.

Objective:
Designing a multi-epitope vaccine from the spike protein of SARS-CoV2 based on immunoinformatics
and in-silico techniques. Evaluating the binding affinity of the constructed vaccine
against the major variants of concern (alpha, beta, delta, and omicron) using docking studies.

Method:
The potential antigenic, immunogenic, and non-allergic T-cell epitopes were thoroughly explored
using IEDB, NetCTL1.2, and NetMHCII pan 3.2 servers. The best suitable linker was identified
using the ExPASy Protparam tool and VERIFY 3D. The 3D model of the vaccine was developed
by RaptorX and the model was validated using ERRAT, Z-score, and Ramachandran Plot. Docking
studies of the vaccine with TLR-2, 3, 4, and 7 and alpha, beta, delta, and omicron variants were performed
using HADDOCK 2.4.

Results:
The vaccine construct showed good antigenic and immunogenic scores and was non-allergic
as well. The model was capable of binding to all four selected Toll-like receptors. Docking scores with
variants were also promising.

Conclusion:
All the variants showed good binding ability with the vaccine construct. Interaction with
the alpha variant was found to be the most intense, followed by delta, beta, and omicron.
Mature Teratoma Revisited: A Rare Isolated Intrapulmonary Presentation:
Case Report
Authors: Ehab Ahmed , Shalabi Ahmad , Nawgiri Avinash , Reissfelder Florian , Graeter Thomas 
Published: September 2022

Background:
Intrathoracic teratoma is a form of germ cell tumors and is mostly found in the anterior mediastinum. Isolated intrapulmonary teratoma (IPT) is by far a rarity. The clinical presentation is often non-specific and radiological images – in most of the cases- is not sufficient to establish a final diagnosis.
Surgical resection is the gold standard curative treatment after proper preoperative assessment.

Case presentation:
In this case report, we describe a case of an IPT in a 33 year old female patient, who presented with hemoptysis, and was successfully treated with right upper lobe resection. The diagnosis was histologically proven as a mature IPT.

Conclusion:
IPT is extremely rare. Surgical resection is the gold standard method for both diagnostic and curative purposes. Strict preoperative assessment should be performed to exclude other cases of lung masses.
Design of Wireless Motion Sensor Nodes based on the Kalman Filter
Algorithm
Authors: Zhang Yuye 
Published: September 2022

Background:
In recent years, wireless sensor network technology has been the center
of attention in the international community. It has been a key element in e-health to monitor bodies.
This technology enables new applications in different domains, including medical, physical
training, etc.

Method:
Some sensors in WSN (Wireless Sensor Nodes) capture physiological data such as
temperature, heartbeat and moving distance. The ECG signal is obtained by an analog front-end
chip ADS1292 and processed by an adaptive Kalman filter algorithm. The sensor LMT70 is used
to gather the body temperature; the acceleration sensor MPU6050 is used to detect, capture, recognize
and identify other body gestures and motions data and the STM32F103C8 microprocessor
is used as the kernel control module. WSN sensor nodes provide wireless monitoring due to transceiver
module NRF24L01for anybody, anywhere and anytime.

Result:
Each measurement result can meet physiological index demands.

Conclusion:
The system can be used to avoid sports accidents and injuries and to plan for future
training and realized in LAB conveniently owing to the high cost-performance ratio.
Possibility of Liver Cancer Treatment By Nanoformulation of Phenolic
Phytochemicals
Authors: Patra Prasun , Banik Debayan 
Published: September 2022

Abstract:
Cancer is a group of disease where the body cells continuously grow without proper cell division thereby causing tumours and leading to metastasis. Among many types of cancer, liver cancer remains a common and leading cause of human death. Plants have always been a great source of medicine and pharmacotherapy. Phytochemicals are plant-produced metabolites and phe-nolic phytochemicals are a subclass of it. Phenolic phytochemicals like curcumin, gallic acid and EGCG are secondary plant metabolites. They have been found to be effective and can improve the cell signalling pathways that govern cancer cell proliferations, inflammations, nearby invasions, and apoptosis. These phenolic phytochemicals greatly induce cell apoptosis and inhibit cancer cell growth. In this review article, we discuss how to improve the mentioned phytochemical's potency against hepatocellular carcinoma (HCC). One of the best approaches to improve the efficacy of these natural phytochemicals is to prepare nano formulations of these phytochemicals. Nano formu-lations impressively increase bioavailability, stability, absorption in the body and increased effi-ciency of these phytochemicals. The diverse character of many nanoparticles (NP) discussed in this article enables these systems to exhibit strong anticancer activity, emphasising combined therapy's benefits and necessity to combat cancer. In addition, nano formulations of these phenolic phyto-chemicals remarkably show a high apoptosis rate against HepG2 cells (HCC).
Preventing and Protecting Against Internet Research Fraud in Anonymous Web-Based Research: Protocol for the Development and Implementation of an Anonymous Web-Based Data Integrity Plan
Authors: Hohn Kris L , Braswell April A , DeVita James M 
Published: September 2022

Background
Data integrity is a priority in any internet research study; it should be maintained to protect the safety and privacy of human participants and to maintain the validity and reliability of research findings. However, one noteworthy risk of web-based research is fraudulent respondent activity. When investigators must utilize anonymous web-based recruitment techniques to reach hidden and expanded populations, steps should be taken to safeguard the integrity of data collected.

Objective
The purpose of this paper is to present a novel protocol in the form of an anonymous web-based research data integrity plan (DIP) protocol that outlines steps for securing data integrity while conducting anonymous web-based data collection.

Methods
In this paper, we discuss a protocol regarding the development and implementation of a specific DIP in response to fraudulent activity in an original large-scale mixed methods study launched in April 2021. Four primary steps, each with a set of affiliated procedures, are presented: (1) defining the risks, (2) planning research protocols, (3) securing data collection and recruitment, and (4) determining enrollment.

Results
Following the relaunch of a large-scale original study and implementation of the DIP protocol, preliminary analyses demonstrated no fraudulent activity. A pre-post analysis is underway to evaluate the effectiveness of the DIP strategies from February 2022 through May 2023.

Conclusions
Implementing the DIP protocol could save valuable research time, provides a process to examine data critically, and enables the contribution of rigorous findings to various health fields.

International Registered Report Identifier (IRRID)
DERR1-10.2196/38550
Study on Socio-Economic of Peatland Community in Tanjung Jabung Timur Regency, Jambi
Authors: Surati Surati 
Published: September 2022

This research aimed to analyze the socio economic and its dynamics of the community in Sidomukti Village, Dendang District, and Pandan Sejahtera Village, Geragai District, Tanjung Jabung Timur Regency, Jambi Province. Respondents were selected purposively based on their farming practices on deep peatlands. Thematic and descriptive analyses were used in this research. The results showed that the majority of the communities of the two villages was Javanese who came to the villages through transmigration programs in the 1980s. Their had insufficient knowledge about peatland utilization because they used to manage mineral soil in their place of origins. Their main jobs were farmers, planters, and laborers with oil palm and areca nut as the main commodities. The average income in Pandan Sejahtera Village was IDR3,832,800/month, greater than in Sidomukti Village which was IDR3,661,850/month. Farmers tended to plant commodities that were currently favored in the market instead of their suitablility with the biophysical conditions of peatlands. Guidance is needed to improve farmers’ knowledge of land management and species selection that have high economic values and market captures as well as are suitable for biophysical properties of deep peatlands and agroforestry techniques.
Kandungan Senyawa Fungsional Daun Tanaman Gaharu (Aquilaria malaccensis) Berdasarkan Posisi Daun pada Cabang
Authors: Santoso Budi , Ginting Berta Sri Kristina , Widowati Tri Wardani , Pangawikan Aldila Din 
Published: September 2022

Penelitian ini bertujuan untuk menganalisa beberapa senyawa metabolit sekunder yang bersifat antikosidan dalam daun tanaman gaharu berdasarkan posisi daun pada cabang. Rancangan percobaan yang digunakan adalah rancangan acak kelompok non faktorial. Perlakuan penelitian terdiri atas tiga faktor, yaitu (A1) daun muda (posisi daun 1-4 helai dari pucuk), (A2) daun sedang (posisi daun 5-8 helai dari pucuk), dan (A3) daun tua (posisi daun 9-12 helai dari pucuk). Hasil penelitian menunjukkan bahwa posisi daun pada cabang tanaman gaharu berpengaruh nyata terhadap jumlah senyawa metabolit sekunder yang dihasilkan. Daun tanaman gaharu mengandung senyawa metabolit sekunder yaitu alkaloid 1,65-4,2%, saponin 2,47-4,00%, tanin 0,69-2,70%, total fenol 29,70-54,68 mg/L, dan total klorofil 9,21-20,03 mg/L. Tannin dan total fenol merupakan senyawa fungsional dalam daun gaharu bersifat antioksidan. Sifat antioksidan daun ini termasuk kategori kuat dengan nilai IC50 sebesar 49,30-68,30 mg/L dimana daun muda lebih tinggi sifat antioksidannya dibanding daun tua.
Global Value Chain Analysis on PT Batik Keris Surakarta
Authors: Suhita Anisa Risanti , Ferdian Ahya Al Putra  , Gregorius Bunga Nanda Jiwa  
Published: September 2022

Batik is an Indonesian cultural heritage that has been recognized by The United Nations Educational, Scientific and Cultural Organization (UNESCO). In addition to cultural heritage, many Indonesian people live through Batik crafts. Batik Keris is one of the Lead Firms in the Batik industries in Surakarta, even in Indonesia, where it plays an important role in the Batik industry and also in preserving Batik itself. This study examines the global value chain of PT. Batik Keris and their role as Lead Firm in the Batik industry and their relationship with the Surakarta City Government program. This study uses a qualitative descriptive method by applying the Global Value Chain Concept introduced by Gerry Gereffi (2016). Meanwhile, the data was obtained through interviews with related sources and literature studies. The results show that Batik Keris has implemented an upgrade strategy ranging from design, use of technology, to carry out various activities such as fashion shows and Batik Carnival.
Keywords: Batik Industry, Batik Keris, Global Value Chain, Local Economic Development
Karakteristik Sifat Manusia dalam Tafsir Fi Zilal Al-Qur’an
Authors: Jamil Shabrun , Yahya Agusni 
Published: September 2022

As a creature chosen to be the leader of the earth, Allah created humans with the highest perfection. But on the other hand, humans have bad traits such as complaining, impatient and miserly. This paper aims to explain the despicable traits that exist in humans according to the interpretation of Sayyid Qutub, so that Islam can stay away from these traits. An important finding in this study is that according to Sayyid Quṭub, the nature of complaining must be possessed by humans, both happy and difficult. However, this trait will be lost if humans can fulfill the conditions mentioned in the Qur'an, namely always in prayer, paying zakat, justifying the last day, guarding his privates, fulfilling promises and trusts, giving true testimony, and always keeping the prayer. Sayyid Quṭub's interpretation was influenced by the social and political life of his time, namely when the Egyptian people and their government were ignorant of Islamic values, damaged faith and morals, violence was everywhere, the government was unjust to society, adultery was rampant, and even the ulama were considered as parasites to do something that is considered good for him. Sebagai makhluk yang dipilih untuk menjadi pemimpin di bumi, Allah menciptakan manusia dengan kesempurnaan tertinggi. Akan tetapi di sisi lain, manusia memiliki sifat yang jelek seperti berkeluh kesah, tidak sabar dan kikir. Tulisn ini bertujuan menjelaskan sifat-sfat tercela yang ada pada manusia menurut penafsiran Sayyid Qutub, sehingga Islam dapat menjauh dari sifat-sifat tersebut. Temuan penting dalam kajian ini bahwa menurut Sayyid Quṭub, sifat keluh kesah pasti dimiliki oleh manusia baik senang maupun susah. Namun, sifat tersebut akan hilang jika manusia dapat memenuhi syarat-syarat yang disebutkan dalam Al-Qur’an, yaitu senantiasa dalam salatnya, membayar zakat, membenarkan hari akhir, menjaga kemaluannya, menunaikan janji dan amanah, memberikan kesaksian yang benar, dan selalu menjaga salatnya. Penafsiran Sayyid Quṭub dipengaruhi oleh kehidupan sosial dan politik pada masanya, yaitu pada saat rakyat Mesir dan pemerintahannya abai terhadap nilai-nilai Islam, rusaknya akidah dan moral, kekerasan dimana-mana, pemerintah berlaku zalim terhadap masyarakat, perzinaan merajalela, bahkan ulama dianggap sebagai benalu untuk melakukan sesuatu hal yang dianggap baik baginya
Kematian dalam Al-Qur’an
Authors: Ajirni Ajirni , Bakar Syukran Abu 
Published: September 2022

All the people who live in this world will surely end in death, no one is able to become an eternal human being on this earth, but the reality is that many people think that death is a terrible thing, so that when a person is experiencing pain, not a few people try their best and cost so that the pain suffered quickly healed and to avoid death. Through the verses of death, God also warns the people on this earth that only we will return and that no creature will be immortal, for eternity belongs only to Him. This research is based on library Research. The main reference source of the study is the Mushaf al-Quran al-Karim which deals with the issue of death, and other references such as the interpretation of Mawḍū'i. From the results of this study, the author found a difference in the meaning of each lafaz that shows the meaning of death in the Qur'an even though it is actually meant by the meaning of death is one that is the loss of spirit from the body. In interpreting death in the context of the Qur'an the scholars of classical and contemporary interpretations do not disagree about life it happened twice and the death occurred twice. Semua makluk yang hidup di dunia ini pasti akan berakhir dengan kematian, tidak ada seorangpun yang mampu menjadi manusia yang abadi di muka bumi ini, namun realitasnya banyak orang-orang yang menganggap bahwa kematian merupakan suatu hal yang mengerikan, sehingga ketika seseorang sedang mengalami sakit, tak sedikit orang berusaha sekuat tenaga dan biaya agar sakit yang dideritanya lekas sembuh dan agar terhindar dari kematian. Melalui ayat-ayat tentang kematian, Allah juga memberikan peringatan bagi manusia yang ada di muka bumi ini, bahwa hanya kepada-Nyalah kita akan kembali dan tidak ada satu makhlukpun akan abadi, karena keabadian hanyalah milik-Nya. Penelitian ini berbasis penelitian kepustakaan (Library Research). Sumber rujukan utama penelitian ini adalah Mushaf al-Quran al-Karim yang membicarakan masalah kematian, dan rujukan lainnya seperti tafsir Mawḍū’i. Dari hasil penelitian ini penulis menemukan perbedaan makna dari setiap lafaz yang menunjukkan makna mati dalam al-Quran walaupun sebenarnya yang dimaksud dari makna mati itu satu yaitu hilangnya ruh dari jasad. Dalam memaknai kematian dalam konteks al-Quran para ulama tafsir klasik dan kontemporer tidak saling berbeda pendapat mengenai kehidupan itu terjadi dua kali dan kematian itu terjadi dua kali
Hijab dalam Kewarisan Islam Berdasarkan Hadis
Authors: Djuned Muslim , Nur Ikhsan 
Published: September 2022

Textually, Islamic inheritance law is the most detailed law mentioned in the Qur'an, but in the settlement of the distribution of inheritance, it often requires re-ijtihad by the scholars. One of the important things in inheritance issues is the hijab issue, which is a barrier for heirs to get inheritance rights due to priority elements or other reasons. Based on the problems above, it is necessary to study in depth about the hijab issue, especially related to the hadith arguments used by scholars as the basis for ijtihad in the hijab issue. This research includes a literature review, while the way it works uses the thematic-correlative method, namely by setting the theme to be discussed and explained based on the theme. The main data used are maqbul hadiths about the hijab of heirs' rights contained in the al-sittah pole. The traditions will be analyzed chronologically based on the thematic-correlative method. The results of the study show that there are several types of hijab in Islamic inheritance that must be applied to prevent disputes between fellow heirs. According to the hadith of the Prophet Muhammad, hijab is a system that reduces or aborts all shares of the inheritance of certain heirs because there are other heirs who are more prioritized or influenced by a forbidden nature attached to the heirs so as to prevent them from obtaining the inheritance. Secara tekstual hukum kewarisan Islam termasuk hukum yang paling rinci disebutkan Alquran, namun dalam penyelesaian pembagian harta warisan sering membutuhkan ijtihad ulang para ulama. Salah satu hal yang penting dalam persolan warisan adalah persoalan hijab, yaitu penghalang bagi ahli waris untuk mendapatkan hak warisan karena unsur prioritas atau alasan lainnya. Berdasarkan permasalahan di atas, maka perlu dikaji secara mendalam tentang persoalan hijab, terutama terkait dengan dalil-dalil hadis yang digunakan para ulama sebagai dasar ijtihad dalam persoalan hijab. Penelitian ini termasuk kajian kepustakaan, sedangkan cara kerjanya menggunakan metode tematis-korelatif, yaitu dengan menetapkan tema yang akan dibahas dan dijelaskan berdasarkan tema. Data utama yang digunakan adalah hadis-hadis maqbul tentang hijab hak ahli waris yang terdapat dalam kutub al-sittah. Hadis-hadis akan dianalisis secara kronologi berdasarkan metode tematis-korelatif. Hasil penelitian menunjukkan terdapat beberapa macam hijab dalam ilmu kewarisan Islam yang harus diterapkan untuk mencegah terjadinya sengketa antara sesama ahli waris. Menurut hadis Rasulullah saw, hijab merupakan suatu sistem yang mengurangi atau menggugurkan seluruh saham harta warisan ahli waris tertentu karena terdapat ahli waris lain yang lebih prioritas atau dipengaruhi suatu sifat terlarang yang melekat pada ahli waris sehingga mencegahnya untuk memperoleh harta warisan.
Lafaz Ru’ya dan Hulm dalam Al-Qur’an
Authors: Nafisah Raudhatun , Aiman Ummul 
Published: September 2022

The problem of dreams in Islam has a very special position. This is because dreams are one of the ways that Allah chose to convey revelation to His prophets through the dreams of the prophets. There are two kinds of dreams that humans often experience, namely good dreams (ru'ya) which is believed to be the bearer of good news and bad dreams (ḥulm) known as bearers of bad news. The author will examine in detail the interpretation of the words ru'ya and ulm in the Qur'an and the context of ru'ya and ulm in the Qur'an. In this study, the author uses library research, namely by collecting data and reviewing library materials. In addition, the author also uses the mauḍu'i method. As a result, the writer finds that the position between the two words above, namely ru'ya and ulm, has its own differences. The difference can be seen in terms of the usefulness of lafaẓ ru'ya which is used to express good and true dreams that come from God, while ulm is often used to convey nightmares or dreams that come from the devil. From the results of this study, it can be concluded that in the Qur'an the word that means dream is nature, while the word ulm is defined as the age of puberty. Permasalahan mimpi dalam Islam mempunyai kedudukan yang sangat istimewa. Hal ini disebabkan mimpi merupakan salah satu jalan yang Allah pilih untuk menyampaikan wahyu kepada nabi-Nya melalui mimpi para nabi. Mimpi yang sering dialami manusia ada dua macam, yaitu mimpi baik (ru’ya) yang dipercaya sebagai pembawa berita baik dan mimpi buruk (ḥulm) dikenal dengan pembawa kabar buruk. Penulis akan mengkaji secara rinci mengenai penafsiran kata ru’ya dan ḥulm di dalam al-Qur’an serta konteks ru’ya dan ḥulm dalam al-Qur’an. Dalam penelitian ini, penulis menggunakan penelitian library research, yakni dengan mengumpulkan data dan menelaah bahan-bahan kepustakaan. Selain itu penulis juga menggunakan metode mauḍu’i. Hasilnya penulis dapatkan bahwa kedudukan antara kedua lafaẓ di atas yaitu ru’ya dan ḥulm memiliki perbedaan tersendiri. Perbedaan itu terlihat dari segi kegunaan lafaẓ ru’ya yang digunakan dalam menyatakan mimpi baik dan benar yang berasal dari Allah, sedangkan ḥulm sering digunakan dalam menyampaikan mimpi buruk atau mimpi yang berasal dari setan. Dari hasil penelitian tersebut dapat disimpulkan bahwasanya dalam al-Qur’an kata yang bermakna mimpi yaitu aḥlam, sedangkan kata ḥulm diartikan sebagai usia baligh.