bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Coronavirus Disease 2019 Hospitalization After Sotrovimab in Patients With Hematologic Malignancy During the BA.1 Omicron Surge
Authors: Yan Judy , Steiger Samantha N , Kodama Rich , Fender Jerome , Tan Carrie , Laracy Justin , Cohen Nina , McMillen Tracy , Jani Krupa , Robilotti Elizabeth V , Babady N Esther , Seo Susan K , Kamboj Mini 
Published: November 2022

Abstract

Background
Sotrovimab is an anti-spike neutralization monoclonal antibody developed to reduce the risk of coronavirus disease 2019 (COVID-19) progression and advancement to hospitalization in high-risk patients. Currently, there is limited research describing the association of sotrovimab treatment in patients with hematologic malignancy and the predictive factors of hospitalization.

Methods
We performed an observational study of 156 consecutive cancer patients who received sotrovimab at Memorial Sloan Kettering Cancer Center in New York City during the BA.1 Omicron surge. We evaluated the demographic, clinical, and laboratory characteristics of the patients who had subsequent COVID-19–related hospitalization(s) compared to those who did not.

Results
Among the 156 study patients, 17 (11%) were hospitalized, of whom 4 were readmitted for COVID-19–related complications; 3 deaths were attributed to COVID-19. Results from multivariable logistic regression show that significant factors associated with hospitalization include patients on anti-CD20 therapy (adjusted odds ratio [aOR], 5.59 [95% confidence interval {CI}, 1.73–18.12]; P = .004) and with relapse/refractory disease (aOR, 5.69 [95% CI, 1.69–19.16]; P = .005). Additionally, whole genome sequencing of severe acute respiratory syndrome coronavirus 2 detected high occurrences of mutations in the spike gene associated with treatment-related resistance longitudinal samples from 11 patients treated with sotrovimab.

Conclusions
While sotrovimab is effective at reducing COVID-19 hospitalization and disease severity in patients with hematologic malignancy when administered early, patients who received anti-CD20 antibodies showed substantial morbidity. Due to the high potential for resistance mutation to sotrovimab and increased morbidity in patients on anti-CD20 therapy, combination treatment should be explored to determine whether it provides added benefits compared to monotherapy.
Physiological and Environmental Influences on Wingbeat Frequency of Oriental Armyworm,Mythimna separata(Lepidoptera: Noctuidae)
Authors: Xu Rui-Bin , Ge Shi-Shuai , Yu Wen-Hua , Li Xiao-Kang , Wu Kong-Ming 
Published: November 2022

AbstractThe oriental armyworm, Mythimna separata (Walker, 1865) (Lepidoptera: Noctuidae), is a serious global migratory insect pest of grain crops. Although its migratory biology has been studied for a long history, the factors affecting wingbeat frequency (WBF), which is closely related to the flight activity of the insect, remain unclear. In this study, the WBFs of both cultured and migrating moths were tested under different conditions in the laboratory using a stroboscope. The results indicated that age and mating status significantly influenced WBF. One day old adults had the lowest WBF, and unmated females had a significantly higher WBF than that of mated females. In general, the WBF of males was significantly higher than that of female individuals. The WBF decreased gradually with increasing environmental humidity, and WBF had a significant negative binomial regression relationship with temperature change. The WBF of moths that fed on hydromel was much higher than those of the controls that fed on water or without diet. However, wind speed and air pressure had no significant effects on the moth WBF in the test environments. These findings provide a deeper understanding of factors that affect flight ability in M. separata, which will be helpful for developing a regional migratory monitoring and warning system of the pest, such as identifying target insect species based on the WBF from radar observation.
Combined effects of exploitation and environmental change on life history: a comparative analysis on Atlantic herring
Authors: Beaudry-Sylvestre Manuelle , Benoît Hugues P , Hutchings Jeffrey A 
Published: November 2022

Abstract
The consequences of fisheries-induced evolution on stock productivity and yield depend, to a large extent, on the general prospects for growth and survival. Here, we compare the selection pressures imposed by two distinct patterns of exploitation—principally targeting spawning or non-spawning aggregations—on age at maturity among 15 Canadian stocks of Atlantic herring (Clupea harengus) that have exhibited a consistent pattern of length-at-age responses to common large-scale environmental drivers since the 1960s. In accordance with expectations for maturity-dependent harvesting, the establishment of a spawner-targeted fishery in the southern Gulf of St. Lawrence coincided with a shift towards delayed maturity in both resident stocks, whereas stocks elsewhere subject to fisheries that also exploited juveniles more commonly exhibited trends towards earlier maturity. Despite these differences, we find that environmentally driven changes in length at maturation, combined with total mortality, may overwhelmingly determine lifetime reproductive success and possibly fitness. By linking phenotypic changes experienced in the juvenile period to simple correlates of egg production in mature age classes, our study highlights the importance of managing fisheries in the context of ubiquitous but contrasting environmental constraints on life histories.
Amenability of Monomial Algebras, Minimal Subshifts, and Free Subalgebras
Authors: Bell Jason P , Greenfeld Be’eri 
Published: November 2022

Abstract
We give a combinatorial characterization of amenability of monomial algebras and prove the existence of monomial Følner sequences, answering a question due to Ceccherini–Silberstein and Samet–Vaillant. We then use our characterization to prove that over projectively simple monomial algebras, every module is exhaustively amenable; we conclude that convolution algebras of minimal subshifts admit the same property. We deduce that any minimal subshift of positive entropy gives rise to a graded algebra, which does not satisfy an extension of Vershik’s conjecture on amenable groups, proposed by Bartholdi. Finally, we show that non-amenable monomial algebras must contain noncommutative free subalgebras. Examples are given to emphasize the sharpness and necessity of the assumptions in our results.
Evaluation of supplemental fat sources and pre-farrow essential fatty acid intake on lactating sow performance and essential fatty acid composition of colostrum, milk, and adipose tissue
Authors: Holen Julia P , Woodworth Jason C , Tokach Mike D , Goodband Robert D , DeRouchey Joel M , Gebhardt Jordan T 
Published: November 2022

Abstract
A total of 91 sows (Line 241, DNA Genetics) were used to evaluate the effects of supplemental fat sources and essential fatty acid intake on sow farrowing performance, litter growth performance, and essential fatty acid composition of colostrum, milk, and adipose tissue. At approximatelyday 107 of gestation, sows were blocked by body weight and parity, then allotted to 1 of 5 experimental treatments as part of a 2 × 2 + 1 factorial arrangement. Experimental diets were corn-soybean meal-based with a control diet that contained no added fat or diets with 3% added fat as either beef tallow or soybean oil, with consumption of the added fat diets starting on day 107 or 112 of gestation and fed until weaning. Thus, sows were provided low essential fatty acids (EFA; as linoleic and α-linolenic acid) without supplemental fat or with beef tallow or high EFA with soybean oil. Sows were provided approximately 2.8 kg/d of their assigned lactation diet pre-farrow and then provided ad libitum access after parturition. Sows consuming diets with beef tallow had greater lactation ADFI (fat source, P = 0.030), but lower daily linoleic acid (LA) and α-linolenic acid (ALA) intake than sows that consumed diets with soybean oil (fat source, P &lt; 0.001). Supplemental fat sources providing either low or high EFA did not influence litter growth performance (fat source, P &gt; 0.05). Sows fed diets with beef tallow did not influence the LA composition of colostrum; however, lactation diets with high EFA provided by soybean oil on day 107 of gestation increased colostrum LA concentration compared to providing diets on day 112 of gestation (fat source × time, P = 0.084; time, P &lt; 0.001). Additionally, regardless of pre-farrow timing, ALA concentration of colostrum increased when sows consumed diets with soybean oil compared to beef tallow (fat source, P &lt; 0.001). Both LA and ALA concentrations of milk at weaning were greater for sows that consumed diets with soybean oil compared to beef tallow (fat source, P &lt; 0.001). Furthermore, concentrations of LA and ALA within adipose tissue were greater at weaning when sows consumed diets with high EFA compared to low EFA (fat source, P &lt; 0.05). These responses suggest that providing dietary fat sources with high concentrations of EFA can increase backfat, colostrum, and milk LA and ALA. However, in this experiment, changes in colostrum and milk composition did not influence litter growth performance.
Extinction and survival of raninoid crabs (Decapoda: Brachyura: Raninoida) from the Early Cretaceous to the present
Authors: Hartzell Samantha M , Schweitzer Carrie E , Feldmann Rodney M 
Published: November 2022

AbstractFaunal turnover is a pattern of diversification and extinction in taxa throughout the geologic record. Patterns of repeated faunal turnovers are referred to as faunal progression, demonstrated by Decapoda in clawed lobsters and podotrematous and heterotrematous crabs. The transition between podotrematous and heterotrematous crabs is the most recent. Among these, section Raninoida Ahyong, Lai, Sharkey, Colgan & Ng, 2007, commonly called “frog crabs,” constitutes a major monophyletic group with podotrematous body forms, and the focus of our study. Declines in raninoidan diversity were aligned with mass extinction events and major climate shifts, especially cooling. Likewise, diversification within Raninoida occurred in warm, greenhouse climates. Thus, a major factor in patterns of faunal turnover in Decapoda is shown to be environmental conditions. Raninoidan families exhibiting adaptations facilitating back-burrowing preferentially survived the end-Cretaceous mass extinction event, whereas raninoidans lacking such adaptions did not go completely extinct at the end-Cretaceous but failed to recover diversity. Given the diversification of heterotrematous crabs into a wide variety of ecological niches throughout the Cenozoic, competition may be a secondary, but still crucial, factor in this faunal turnover.
The impact of habitat loss on molecular signatures of coevolution between an iconic butterfly (Alcon blue) and its host plant (Marsh gentian)
Authors: Warson Jonas , Baguette Michel , Stevens Virginie M , Honnay Olivier , De Kort Hanne 
Published: November 2022

AbstractHabitat loss is threatening natural communities worldwide. Small and isolated populations suffer from inbreeding and genetic drift, which jeopardize their long-term survival and adaptive capacities. However, the consequences of habitat loss for reciprocal coevolutionary interactions remain poorly studied. In this study, we investigated the effects of decreasing habitat patch size and connectivity associated with habitat loss on molecular signatures of coevolution in the Alcon blue butterfly (Phengaris alcon) and its most limited host, the marsh gentian (Gentiana pneumonanthe). Because reciprocal coevolution is characterized by negative frequency-dependent selection as a particular type of balancing selection, we investigated how signatures of balancing selection vary along a gradient of patch size and connectivity, using single nucleotide polymorphisms (SNPs). We found that signatures of coevolution were unaffected by patch characteristics in the host plants. On the other hand, more pronounced signatures of coevolution were observed in both spatially isolated and in large Alcon populations, together with pronounced spatial variation in SNPs that are putatively involved in coevolution. These findings suggest that habitat loss can facilitate coevolution in large butterfly populations through limiting swamping of locally beneficial alleles by maladaptive ones. We also found that allelic richness (Ar) of the coevolutionary SNPs is decoupled from neutral Ar in the butterfly, indicating that habitat loss has different effects on coevolutionary as compared with neutral processes. We conclude that this specialized coevolutionary system requires particular conservation interventions aiming at generating a spatial mosaic of both connected and of isolated habitat to maintain coevolutionary dynamics.
Successful treatment of a patient with Takayasu’s arteritis complicated with Crohn’s disease with ustekinumab: A case report
Authors: Suga Takeshi , Hidaka Yukiko , Hori Maisa , Yamasaki Hiroshi , Wakasugi Daisuke , Yamasaki Satoshi , Yamaguchi Rin , Ida Hiroaki , Nakashima Munetoshi 
Published: November 2022

ABSTRACT
A 17-year-old woman was referred to our department with fever, general malaise, and weight loss. She was diagnosed with Takayasu arteritis (TAK) and Crohn’s disease (CD) following positron emission tomography-computed tomography (PET-CT) and colonoscopy, respectively. Serological human leukocyte antigen (HLA) typing revealed HLA-B52 positivity. Initial treatment with prednisolone (PSL) (0.5 mg/kg) was insufficient; therefore, ustekinumab and 5-aminosalicylic acid were added. This treatment achieved PSL-free remission for both diseases, as confirmed by PET-CT and colonoscopy. Although treatment guidelines for TAK and CD have been previously established, treatment of patients with TAK with coexisting CD is controversial. Our case suggests that ustekinumab has the ability to achieve TAK remission in addition to its therapeutic effect on CD.
NPASS database update 2023: quantitative natural product activity and species source database for biomedical research
Authors: Zhao Hui , Yang Yuan , Wang Shuaiqi , Yang Xue , Zhou Kaicheng , Xu Caili , Zhang Xuyao , Fan Jiajun , Hou Dongyue , Li Xingxiu , Lin Hanbo , Tan Ying , Wang Shanshan , Chu Xin-Yi , Zhuoma Dongzhi , Zhang Fengying , Ju Dianwen , Zeng Xian , Chen Yu Zong 
Published: November 2022

AbstractQuantitative activity and species source data of natural products (NPs) are important for drug discovery, medicinal plant research, and microbial investigations. Activity values of NPs against specific targets are useful for discovering targeted therapeutic agents and investigating the mechanism of medicinal plants. Composition/concentration values of NPs in individual species facilitate the assessments and investigations of the therapeutic quality of herbs and phenotypes of microbes. Here, we describe an update of the NPASS natural product activity and species source database previously featured in NAR. This update includes: (i) new data of ∼95 000 records of the composition/concentration values of ∼1 490 NPs/NP clusters in ∼390 species, (ii) extended data of activity values of ∼43 200 NPs against ∼7 700 targets (∼40% and ∼32% increase, respectively), (iii) extended data of ∼31 600 species sources of ∼94 400 NPs (∼26% and ∼32% increase, respectively), (iv) new species types of ∼440 co-cultured microbes and ∼420 engineered microbes, (v) new data of ∼66 600 NPs without experimental activity values but with estimated activity profiles from the established chemical similarity tool Chemical Checker, (vi) new data of the computed drug-likeness properties and the absorption, distribution, metabolism, excretion and toxicity (ADMET) properties for all NPs. NPASS update version is freely accessible at http://bidd.group/NPASS.
Gene co-expression analyses of health(span) across multiple species
Authors: Möller Steffen , Saul Nadine , Projahn Elias , Barrantes Israel , Gézsi András , Walter Michael , Antal Péter , Fuellen Georg 
Published: November 2022

AbstractHealth(span)-related gene clusters/modules were recently identified based on knowledge about the cross-species genetic basis of health, to interpret transcriptomic datasets describing health-related interventions. However, the cross-species comparison of health-related observations reveals a lot of heterogeneity, not least due to widely varying health(span) definitions and study designs, posing a challenge for the exploration of conserved healthspan modules and, specifically, their transfer across species. To improve the identification and exploration of conserved/transferable healthspan modules, here we apply an established workflow based on gene co-expression network analyses employing GEO/ArrayExpress data for human and animal models, and perform a comprehensive meta-study of the resulting modules related to health(span), yielding a small set of literature backed health(span) candidate genes. For each experiment, WGCNA (weighted gene correlation network analysis) was used to infer modules of genes which correlate in their expression with a ‘health phenotype score’ and to determine the most-connected (hub) genes (and their interactions) for each such module. After mapping these hub genes to their human orthologs, 12 health(span) genes were identified in at least two species (ACTN3, ANK1, MRPL18, MYL1, PAXIP1, PPP1CA, SCN3B, SDCBP, SKIV2L, TUBG1, TYROBP, WIPF1), for which enrichment analysis by g:profiler found an association with actin filament-based movement and associated organelles, as well as muscular structures. We conclude that a meta-study of hub genes from co-expression network analyses for the complex phenotype health(span), across multiple species, can yield molecular-mechanistic insights and can direct experimentalists to further investigate the contribution of individual genes and their interactions to health(span).
Caveats of Using Bacterial Type Three Secretion Assays for Validating Fungal Avirulence Effectors in Wheat
Authors: Jensen Cassandra , Korolev Andrey , Corredor-Moreno Pilar , Minter Francesca , Dodds Peter N. , Saunders Diane G. O. 
Published: November 2022

Functional characterization of effector proteins of fungal obligate biotrophic pathogens, especially confirmation of avirulence (Avr) properties, has been notoriously difficult, due to the experimental intractability of many of these organisms. Previous studies in wheat have shown promising data suggesting the type III secretion system (T3SS) of bacteria may be a suitable surrogate for delivery and detection of Avr properties of fungal effectors. However, these delivery systems were tested in the absence of confirmed Avr effectors. Here, we tested two previously described T3SS-mediated delivery systems for their suitability when delivering two confirmed Avr effectors from two fungal pathogens of wheat, Puccinia graminis f. sp. tritici and Magnaporthe oryzae pathotype tritici. We showed that both effectors (AvrSr50 and AvrRmg8) were unable to elicit a hypersensitive response on wheat seedlings with the corresponding resistance gene when expressed by the Pseudomonas fluorescens “Effector to Host Analyser” (EtHAn) system. Furthermore, we found the utility of Burkholderia glumae for screening Avr phenotypes is severely limited, as the wild-type strain elicits nonhost cell death in multiple wheat accessions. These results provide valuable insight into the suitability of these systems for screening fungal effectors for Avr properties that may help guide further development of surrogate bacterial delivery systems in wheat. [Formula: see text] Copyright © 2022 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Public health services and intersectional stigma: a social sciences perspective with implications for HIV service design and delivery
Authors: Tan Rayner Kay Jin , Tang Weiming , Tucker Joseph D. 
Published: November 2022

Purpose of reviewUnderstanding stigma is important for improving HIV care services and gaps in HIV service delivery have been attributed to stigma. This review article synthesizes recent evidence on stigma and its implications for HIV service design and delivery. Given the intersectional nature of stigma, we will focus on HIV stigma as well as related forms of stigma based on one's race, sexual identity, gender identity and other identities.Recent findingsStigma remains a barrier to achieving equity in HIV services. Individualistic measures of stigma remain influential and are associated with barriers to accessing HIV health services. Recent work also highlights stigma measured at a structural level and its impact on HIV services contexts. Individuals situated at intersections of marginalized identities continue to face greatest injustices, and although intersectional approaches have been adapted to design services at a micro level, few focus on structural change. Recent evidence for mitigating stigma indicates some success for psychosocial interventions that target internalized stigma. Furthermore, community-led approaches show promise in addressing stigma that manifests in HIV health services settings.SummaryInterventions that address individual-level stigma and structural stigma are needed. Theoretical and applied antistigma research is needed to make HIV services more equitable.
Survey of Well-Being of Young Children (SWYC): Preliminary Norms for Screening for Developmental Delay in Brazilian Children Younger than 65 Months
Authors: Guimarães Marina Aguiar Pires , Magalhães Lívia de Castro , Moreira Rafaela Silva , Bessa Francilena Ribeiro , Alves Claudia Regina Lindgren 
Published: November 2022

ABSTRACT:

Objective:
The objective of this study was to investigate the reliability and validity of the Developmental Milestones Questionnaire of the Survey of Wellbeing of Young Children Brazilian version (DM-SWYC-BR) and establish the preliminary norms to identify suspected developmental delay in Brazilian children up to 65 months.

Methods:
A psychometric study was conducted on 1535 children from 3 Brazilian regions. The caregivers answered the Brazilian Portuguese cross-culturally adapted version of the DM-SWYC. We calculated the internal consistency and performed an exploratory factor analysis (EFA). The clinical threshold for the suspected developmental delay was set at 85% from the DM-SWYC-BR mean score for each age. The prevalence of suspected delay was calculated using current preliminary cutoffs and original norms.

Results:
EFA confirmed the unidimensionality of the DM-SWYC-BR items (average variance extracted = 0.78). Cronbach's alpha was 0.97. At most ages, the difference between the cutoff points in the Brazilian and North American samples was lower than or equal to 2 points, except at 18, 23, 29, 44, 45, 46, and from 54 to 58 months. There was a marked divergence in the prevalence of suspected developmental delay by age ranges using the Brazilian or North American cutoff points. However, the general mean prevalence was quite similar (27.5% vs. 28.2%, respectively).

Conclusions:
We established the cutoff points to interpret the DM-SWYC-BR results when screening for developmental delays in Brazilian children. The satisfactory psychometric properties support its use for screening developmental delays in the public health system. Reliable assessment tools are critical to promoting child development effectively, ensuring timely intervention.