bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of chronic graft-versus-host disease on quality of life and cognitive function of long-term transplant survivors after allogeneic hematopoietic stem cell transplantation with total body irradiation
Authors: Gruber Isabella , Koelbl Oliver , Herr Wolfgang , Holler Ernst , Edinger Matthias , Wolff Daniel 
Published: November 2022

Abstract
Background
Total body irradiation (TBI)-based-conditioning before allogeneic hematopoietic stem cell transplantation (allo-HSCT) is standard of care in patients with acute myeloid leukemia (AML) but can cause long-term morbidity. Data on the impact of chronic Graft-versus-host disease (cGvHD) on cognitive function (CF) and quality of life (QoL) of long-term transplant survivors are sparse.

Methods
We analyzed patient-reported outcomes focusing on progression-free AML patients and 1st allo-HSCT applying a standardized TBI-technique with an average dose rate of 4 cGy/min to the total body and lung shielding in case of doses > 8 Gy. Instruments included the Functional Assessment of Cancer Therapy-Bone marrow transplant (FACT-BMT, version 4), the FACT-Cognition Function (FACT-Cog, version 3) and the Patient Health Questionaire-4 (PHQ-4). We put focus on the impact of cGvHD and compared the results to normative data derived from the general population.

Results
Out of 41 eligible patients contacted, 32 (78.0%) patients with a medium follow-up of 154 months (Interquartile range 113, 191 months) participated in the study. Eleven patients (34.4%) had active cGvHD, 11 (34.4%) resolved cGvHD and 10 (31.3%) never had cGvHD. Patients with active cGvHD had poorer FACT-BMT, FACT-Cog and higher PHQ-4 scores compared to patients with resolved cGvHD or who never had cGvHD. Outcomes were similar in patients with resolved cGvHD and those who never had cGvHD. Patients with active cGvHD had similar FACT-Cog, but lower FACT-BMT in comparison to normative data. However, the overall patient sample had similar FACT-BMT and FACT-Cog in comparison to normative data.

Conclusion
Our data indicate that CF of long-term survivors upon TBI-based allo-HSCT is not impaired, even in the presence of active cGvHD. However, active cGvHD has a negative impact on QoL.
Trial registration The local Ethics Board of the University of Regensburg approved this study (Number 20-1810_1-101).
Small extracellular vesicles derived from Nrf2-overexpressing human amniotic mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting NLRP3
Authors: Xu Lijuan , Zhu Yunlou , Li Congye , Wang Qixing , Ma Lijie , Wang Junjie , Zhang Shouqin 
Published: November 2022

Abstract
Background
Acute lung injury (ALI) is a major cause of respiratory failure in critically ill patients that results in significant morbidity and mortality. Recent studies indicate that cell-based therapies may be beneficial in the treatment of ALI. We recently demonstrated that Nrf2-overexpressing human amniotic mesenchymal stem cells (hAMSCs) reduce lung injury, fibrosis and inflammation in lipopolysaccharide (LPS)-challenged mice. Here we tested whether small extracellular vesicles (sEVs) derived from Nrf2-overexpressing hAMSCs (Nrf2-sEVs) could protect against ALI. sEVs were isolated from hAMSCs that overexpressed (Nrf2-sEVs) or silenced (siNrf2-sEVs) Nrf2. We examined the effects of sEVs treatment on lung inflammation in a mouse model of ALI, where LPS was administered intratracheally to mice, and lung tissues and bronchoalveolar lavage fluid (BALF) were analyzed 24 h later.

Methods
Histological analysis, immunofluorescence microscopy, western blotting, RT-PCR and ELISA were used to measure the inflammatory response in the lungs and BALF.

Results
We found that sEVs from hAMSCs are protective in ALI and that Nrf2 overexpression promotes protection against lung disease. Nrf2-sEVs significantly reduced lung injury in LPS-challenged mice, which was associated with decreased apoptosis, reduced infiltration of neutrophils and macrophages, and inhibition of pro-inflammatory cytokine expression. We further show that Nrf2-sEVs act by inhibiting the activation of the NLRP3 inflammasome and promoting the polarization of M2 macrophages.

Conclusion
Our data show that overexpression of Nrf2 protects against LPS-induced lung injury, and indicate that a novel therapeutic strategy using Nrf2-sEVs may be beneficial against ALI.
Long-term Treatment With Metyrapone in a Man With Ectopic Cushing Syndrome
Authors: Wong Tin Wai 
Published: November 2022

Abstract
This is a unique case of ectopic adrenocorticotropic hormone (ACTH)-secreting mediastinal neuroendocrine tumor, presumably thymic in origin, with suspected lung metastasis in a 61-year-old man who was successfully managed with long-term metyrapone alone. He presented with severe hypokalemia and hypertension, complicated with psychosis and vertebral collapse. He survived through a complicated course of pulseless ventricular tachycardia arrest and a severe Cushing storm due to drug nonadherence. For 3 years since diagnosis, he remained stable on metyrapone, and was able to achieve biochemical eucortisolism, with normalization of ACTH and cortisol levels. In addition, his tumor was reduced in size and the suspicious lung metastasis regressed.
Alström Syndrome: A Rare Cause of Severe Insulin Resistance
Authors: Radi Suhaib , Binmahfooz Saleh , Nawar Samah , Malaikah Hebah 
Published: November 2022

Abstract
Diabetes mellitus is one of the most common diseases worldwide and is a major cause of morbidity and mortality. Type 2 diabetes, with its hallmark being insulin resistance, constitutes the majority of cases. Although usually related to modifiable risk factors, insulin resistance can have genetic causes. Here, we present one of the rare causes of insulin resistance. A 21-year-old man, who was deaf and blind, presented with a 3-week history of polyuria and polydipsia. He was found to have significant hyperglycemia, managed initially with insulin infusion, then he was transitioned to subcutaneous injections. Because he required high doses of insulin and had acanthosis nigricans, insulin resistance was suspected. Putting together his insulin resistance and chronic history of syndromic features, Alström syndrome was considered. Genetic testing revealed a mutation in the ALMS1 gene. The patient was then started on insulin sensitizers with a tapering of insulin with good response. Insulin resistance should be suspected if the insulin requirement is high and if acanthosis nigricans is present. Alström syndrome is a rare causes of insulin resistance. Affected individuals will usually have insulin-resistant diabetes by a young age and associated blindness and deafness. Insulin sensitizers are an important part of the treatment.
Improvement in Serum Magnesium Levels With Sodium-Glucose Cotransporter 2 Inhibitors
Authors: Saha Arunava , Omer Abdulkadir , Trivedi Nitin 
Published: November 2022

Abstract
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are associated with a modest but significant increase in serum magnesium levels. This report describes improvement in serum magnesium and associated symptoms after initiating SGLT2i therapy in a patient with refractory hypomagnesemia. A 58-year-old woman presented with persistent hypomagnesemia refractory to oral magnesium supplements. She had history of type 2 diabetes mellitus, hypothyroidism, fibromyalgia, and degenerative disk disease. The cause of hypomagnesemia was attributed to excessive renal losses. Laboratory investigations revealed serum magnesium of 1.2 mg/dL with fractional excretion of magnesium of 8.9%. She was started on empagliflozin 10 mg daily. Within 4 weeks of therapy, her serum magnesium level corrected with symptomatic improvement, which was sustained a few weeks later. Subsequently, her oral magnesium supplements dose was reduced. SGLT2i has been shown to improve magnesium levels in patients with urinary magnesium wasting. Several mechanisms have been postulated, but the exact physiology remains unknown. SGLT2i have been efficacious for glycemic control, renal protection, decreasing the risk of atherosclerotic cardiovascular disease events, and cardiac mortality in patients with diabetes. In addition, renal and cardiac benefits are also demonstrated in patients without diabetes. This observation demonstrates that SGLT2i can improve the management of patients with otherwise intractable hypomagnesemia.
Cruel Husbandry
Authors: Shetty Sandhya 
Published: November 2022

Abstract
Long read in relation to public health and gender/sexual mores, Katherine Mayo's Mother India (1927) has rarely been viewed from an animal studies perspective. This article proposes that the animal, tethered to the woman question and to the figure of the Muslim, is integral to the book's imperialist apologetics. Investigations of physical cruelty to women and to animals build Mayo's case against Hindu nationalists' bid for self-rule. Highlighting cruelty alongside the question of dietary choice, Mayo interrogates the self-representation of the Hindu vegetarian as nonviolent, rewriting him instead as rapacious carnivore in every sense but the literal. Mobilized in different contexts and modes, the abused animal becomes part of Mayo's arsenal of shaming rhetoric, as does the figure of the “internationalist” Muslim who is imagined as bulwark against the Hindu vegetarian and as dysgenic threat and “world-menace.” Mother India's political-theological engagement with “the Muslim” as the iconoclastic meat eater pits him against the unfit, diabetic Hindu in a fantasy of carnivory and carnage that enacts a wished-for solution to the problem of defending empire.
Other than Human
Authors: Judge Rajbir Singh , Roy Parama 
Published: November 2022

AbstractThis special section, “Other Than Human: Rethinking Colonial and Postcolonial South Asia,” speaks to the ways in which the other than human puts pressure on our sense of the secular contours of imperial rule and the postcolonial condition. Shifting from simply undoing the distinction between human and the other than human, each contributor grapples with how the other than human refuses to provide any easy to grasp object or politics, especially once its secularity is not taken as given. The authors establish the epistemological possibilities and challenges that inhere in probing the secular limits of our received understanding of the other than human—a received understanding that typically undergirds the work even of those whose scholarly archive encompasses the nonsecular. Such an expansive, nonsecular sense of the other than human is a slippery one that is incommensurable rather than compatible with protocols of legibility and recognition, as well as the calculations these involve.
Transformaciones en el framing y la producción periodística de los noticieros televisivos peruanos durante la COVID-19
Authors: Karbaum padilla Gerardo 
Published: November 2022

Apenas apareció la covid-19 la producción de información mediática se vio afectada por las restricciones de distanciamiento social y por los mismos peligros sanitarios que afrontaban los periodistas para cumplir su labor. Esta investigación tiene como objetivo conocer las transformaciones que se aplicaron en la producción de los noticieros televisivos en el Perú, uno de los países más golpeados por la pandemia a escala mundial. Para desarrollarla se aplicó la metodología cualitativa mediante entrevistas semiestructuradas a periodistas que ejercieron labores durante este periodo, y se obtuvieron resultados que revelan la aplicación de diversos dispositivos y procesos inhabituales o no televisivos. Esto fue transversal a las tres etapas de la producción audiovisual, que son la preproducción, la cobertura y la posproducción, situación que nunca antes se había aplicado con tanta intensidad y permanencia. Todo lo anterior permite establecer como conclusión que la producción de noticieros tuvo que recurrir a la hibridación de tecnologías y procedimientos para continuar ejecutando su labor en un contexto inesperado y complicado.
py-irt: A Scalable Item Response Theory Library for Python
Authors: Lalor John Patrick , Rodriguez Pedro 
Published: November 2022

py-irt is a Python library for fitting Bayesian item response theory (IRT) models. At present, there is no Python package for fitting large-scale IRT models. py-irt estimates latent traits of subjects and items, making it appropriate for use in IRT tasks as well as in ideal point models. py-irt is built on top of the Pyro and PyTorch frameworks and uses GPU-accelerated training to scale to large data sets. It is the first Python package for large-scale IRT model fitting. py-irt is easy to use for practitioners and also allows for researchers to build and fit custom IRT models. py-irt is available as open-source software and can be installed from GitHub or the Python Package Index. History: Accepted by Ted Ralphs, Area Editor for software tools. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplementary Information [ https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.1250 ] or is available from the IJOC GitHub software repository ( https://github.com/INFORMSJoC ) at [ http://dx.doi.org/10.5281/zenodo.6818509 ].
Ambiguity Aversion and Beating Benchmarks: Does it Create a Pattern?
Authors: Kolasinski Adam , Li Xu , Soliman Mark , Xin Qian 
Published: November 2022

The prior literature on analyst forecasts has focused almost exclusively on firms that just meet or beat the mean or median consensus analyst forecast, without much regard to alternative benchmarks within the forecast distribution. Anecdotal evidence suggests that there is institutional significance to the lowest (minimum) and highest (maximum) analyst earnings forecast. We rigorously explore whether these two new benchmarks actually have incremental significance and, if so, whether there are differences in how managers and investors perceive the importance of these three benchmarks (i.e., minimum, mean, and maximum). Consistent with the theory of investor ambiguity aversion, which predicts an asymmetric market response to good and bad news, our results support the notion that of the three benchmarks we explore, firms act most aggressively to exceed the minimum forecast, followed by the mean, and then finally the maximum. This order is consistently supported by the following evidence: the existence of higher incentives to beat the benchmark; the likelihood of earnings management to beat the benchmark; accrual reversal after firms just barely achieve each benchmark; accrual mispricing around each benchmark; and, finally, a faster incorporation into the stock price of the bad news that a firm misses the minimum than of the good news that a firm meets or beats the maximum. These findings fill a void in academic research on these two new benchmarks and offer a consistent explanation as to why the popular press and managers frequently highlight and discuss beating these benchmarks as a separate and notable achievement. This paper was accepted by Brian Bushee, accounting. Funding: Q. Xin gratefully acknowledges the financial support from the “Shenzhen Peacock Plan” start-up research [Grant GA11409004] and the Shenzhen Key Research Base of Humanities and Social Sciences [Grant KP191001]. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2022.4609 .
Nonasymptotic Convergence Rates for the Plug-in Estimation of Risk Measures
Authors: Bartl Daniel , Tangpi Ludovic 
Published: November 2022

Let ρ be a general law-invariant convex risk measure, for instance, the average value at risk, and let X be a financial loss, that is, a real random variable. In practice, either the true distribution μ of X is unknown, or the numerical computation of [Formula: see text] is not possible. In both cases, either relying on historical data or using a Monte Carlo approach, one can resort to an independent and identically distributed sample of μ to approximate [Formula: see text] by the finite sample estimator [Formula: see text] (μNdenotes the empirical measure of μ). In this article, we investigate convergence rates of [Formula: see text] to [Formula: see text]. We provide nonasymptotic convergence rates for both the deviation probability and the expectation of the estimation error. The sharpness of these convergence rates is analyzed. Our framework further allows for hedging, and the convergence rates we obtain depend on neither the dimension of the underlying assets nor the number of options available for trading.Funding: Daniel Bartl is grateful for financial support through the Vienna Science and Technology Fund [Grant MA16-021] and the Austrian Science Fund [Grants ESP-31 and P34743]. Ludovic Tangpi is supported by the National Science Foundation [Grant DMS-2005832] and CAREER award [Grant DMS-2143861].
Investigation of Thermal Effects on Nailed Connection of Mass Ply Panels
Authors: Ho Tu X. , Laughery Detlef C. , Sinha Arijit 
Published: November 2022

Abstract
Mass ply panels (MPP), a relatively new mass timber product, has been utilized in several construction projects as diaphragm and wall panels. Connection for MPP is a crucial structural component that requires a better understanding. This article presents an experimental investigation into elevated temperature exposure–driven property degradation of MPP nailed connections, which is important for both the design of new structures in terms of fire resistance and the rehabilitation of structures partially damaged by fire. One control group and 32 exposure groups, which were combinations of eight elevated temperatures and four exposure durations, were investigated. The failure modes and yield strength of the nailed connection were analyzed as a function of elevated temperature and exposure time and compared with the prediction from the National Design Specification and existing literature. The results show a decrease of up to 45 percent in initial stiffness and ultimate load; meanwhile, there was no statistical evidence for the change in yield load in the majority of testing groups. Two analytical models, namely, multilinear regression and first-order kinetics model, were proposed to model the degradation of initial stiffness and ultimate strength. The kinetics model provided a better prediction and suggested that the initial stiffness and ultimate strength of the nail connection degraded over time at rates depending on the exposure temperature.
Polarization beam splitter based on the asymmetric directional coupler of lithium niobate film
Authors: Wang Fang , Liu Hua , Ma Tao , Ma Shoudao , Liu Yufang 
Published: November 2022

A polarization beam splitter (PBS) based on a lithium niobate film
asymmetric directional coupler is proposed. The PBS is located on a
lithium niobate platform on an insulator consisting of a silicon
nitride–lithium niobate waveguide (SLW) and a lithium niobate
waveguide (LNW). By rationally designing the SLW and LNW sizes, TE
polarization satisfies the phase matching condition and TM
polarization phase mismatch. The numerical simulation results show
that the extinction ratio (ER) and insertion loss (IL) of PBS for TE
mode are 30.57 and 0.66 dB, respectively, and the ER and IL of
PBS for TM mode are 28.15 and 0.11 dB, respectively, at an
operating wavelength of 1.55 µm.
Gut microbiome alterations in preclinical Alzheimer’s disease
Authors: Jung Joon Hyung , Kim Gihyeon , Byun Min Soo , Lee Jun Ho , Yi Dahyun , Park Hansoo , Lee Dong Young ,   for the KBASE Research Group
Published: November 2022

Background
Although some human studies have reported gut microbiome changes in individuals with Alzheimer’s disease (AD) dementia or mild cognitive impairment (MCI), gut microbiome alterations in preclinical AD, i.e., cerebral amyloidosis without cognitive impairment, is largely unknown.

Objective
We aimed to identify gut microbial alterations associated with preclinical AD by comparing cognitively normal (CN) older adults with cerebral Aβ deposition (Aβ+ CN) and those without cerebral Aβ deposition (Aβ− CN).

Methods
Seventy-eight CN older participants (18 Aβ+ CN and 60 Aβ− CN) were included, and all participants underwent clinical assessment and Pittsburg compound B–positron emission tomography. The V3–V4 region of the 16S rRNA gene of genomic DNA extracted from feces was amplified and sequenced to establish the microbial community.

Results
Generalized linear model analysis revealed that the genera Megamonas (B = 3.399, q<0.001), Serratia (B = 3.044, q = 0.005), Leptotrichia (B = 5.862, q = 0.024) and Clostridium (family Clostridiaceae) (B = 0.788, q = 0.034) were more abundant in the Aβ+ CN group than the Aβ− CN group. In contrast, genera CF231 (B = −3.237, q< 0.001), Victivallis (B = −3.447, q = 0.004) Enterococcus (B = −2.044, q = 0.042), Mitsuokella (B = −2.119, q = 0.042) and Clostridium (family Erysipelotrichaceae) (B = −2.222, q = 0.043) were decreased in Aβ+ CN compared to Aβ− CN. Notably, the classification model including the differently abundant genera could effectively distinguish Aβ+ CN from Aβ− CN (AUC = 0.823).

Conclusion
Our findings suggest that specific alterations of gut bacterial taxa are related to preclinical AD, which means these changes may precede cognitive decline. Therefore, examining changes in the microbiome may be helpful in preclinical AD screening.
El Teje: Primer Periódico Travesti Latinoamericano, o de cómo resignificar cuerpos que hablen y militen
Authors: Méndez Mariela 
Published: November 2022

Resumen
Este ensayo toma como foco de análisis las representaciones textuales del travestismo en diálogo con la regularización y reglamentación de los actos travestis desde el Estado, a partir de una examinación exhaustiva de El Teje: Primer Periódico Travesti Latinoamericano, el cual surge en Buenos Aires, Argentina, en el 2007. Como revela su directora Marlene Wayar en el segundo editorial del número inaugural: “Cada vez que leemos un diario o una revista, para poder identificarnos tenemos que imaginarnos en otros cuerpos y en otras formas de sentir y de pensar”. Este ensayo se ocupará de mirar de cerca los cuerpos expuestos en El Teje, como contradiscurso que resiste esos cuerpos “otros” de los que se queja Wayar. El uso de la palabra “contradiscurso” es aquí intencional; el teje se construye también a partir de un intento, como sugiere el primer editorial, de “dar voz a través de la palabra materializada y con cierta sistematización al silencio social histórico del que somos víctimas las travestis y transexuales”. ¿En qué consiste entonces esta nueva “palabra materializada” y cómo se relaciona al cuerpo? ¿Cómo se configura la imagen travestida de El Teje? ¿Rompe el silencio? y, lo que importa aún más, ¿Cómo engarza esta imagen corporizada y materializada, esta revista de dimensiones inusuales y colores chillones, imposible de ignorar, con los discursos oficiales sobre la comunidad LGBTTIQ que circulan en la capital argentina cuando se inicia el nuevo milenio?
Memory Mambode Achy Obejas: Un pasoadelantemás allá del guión
Authors: Aguiló-Mora Francisca 
Published: November 2022

ResumenEste ensayo analiza cómo Memory Mambo (1996), la novela debut de Achy Obejas, desarticula conceptualizaciones binarias alrededor de la noción de indentidades con guión (v.g. cubana-americana). Esta desarticulación se lleva a cabo en un plano lingüístico por un lado, y a nivel temático estructural por el otro. Al mismo tiempo, la titular importancia del mambo, como género musical y como metáfora cultural, tiene el efecto de movilizar las memorias narradas, dejando espacio para concordancias y disonancias que sobrepasan los bordes de las dos culturas (la cubana en el exilio y la estadounidense) que informan y atraviesan la novela. Además, el presente artículo explora cómo el imaginario narrativo de Obejas propone nueves formas de ser y estar para las nuevas generaciones diaspóricas de Estados Unidos.