bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implications of elevation-dependent warming to water resources over the Chinese Qilian Mountains
Authors: Zhao Peng , He Zhibin , Du Jun 
Published: December 2022

AbstractWarming in mountainous regions has experienced obvious elevation dependence (the warming rate of air temperature is amplified with elevation), which accelerates the melting of ice and snow, affecting glacier size and mass, and water resources in mountainous regions. Here, we used ERA5-Land monthly averaged datasets from 1979 to 2019 to analyze the elevation-dependent warming (EDW) variability, driving factor, and its implications to water resources in the Qilian Mountains (QLM). Results showed that: (1) Annual mean temperature shows a significant increasing trend in the QLM from 1979 to 2019 (0.31 °C/10a; p &lt; 0.01), and the warming rate of annual mean temperature increased with elevation in the QLM in general. For seasonal scales, the most obvious EDW was found in summer. In the past 41 years, snow cover and snow depth showed a slight decreasing trend. There was a significant negative correlation between temperature and snow cover, which can explain that enhanced regional warming has caused decreases in snow cover and snow depth, largely controlling the pattern of EDW on the QLM. EDW has significant implications for water resources over QLM, especially above 5,000 m. Our study can provide a reference in understanding the importance of EDW to water resources in mountainous areas.
Wastewater monitoring of COVID-19: a perspective from Scotland
Authors: Fang Zhou , Roberts Adrian M. I. , Mayer Claus-Dieter , Frantsuzova Anastasia , Potts Jackie M. , Cameron Graeme J. , Singleton Peter T. R. , Currie Iona 
Published: December 2022

Abstract
Scotland introduced wastewater monitoring for COVID-19 early in the pandemic. From May 2020, samples have been taken and analysed using quantitative polymerase chain reaction (qPCR). The programme was expanded to over 100 sites accounting for around 80% of the population. Data are presented publicly via a dashboard and regular reports are produced for both the public and health professionals. Wastewater-based epidemiology (WBE) offers opportunities and challenges. It offers an objective means of measuring COVID-19 prevalence and can be more practical or timely than other methods of mass testing. However, it also has substantial variability impacted by multiple environmental factors. Methods for data collection and analysis have developed significantly through the pandemic, reflecting the evolving situation and policy direction. We discuss the Scottish experience of wastewater monitoring for COVID-19, with a focus on the analysis of data. This includes our approach to flow normalisation, our experience of variability in measurements and anomalous values, and the visualisation and presentation of data to stakeholders. Summarising the Scottish methodology as of March 2022, we also discuss how wastewater data were used for informing policy and public health actions. We draw lessons from our experience and consider future directions for WBE in Scotland.
Effects of Exercise on Circulating Muscle-related Cytokines in Adults with
Type 2 Diabetes and/or Obesity
Authors: Hamasaki Hidetaka 
Published: December 2022

Background:
Skeletal muscle is an endocrine organ that plays an important role in metabolic
health by secreting a variety of myokines. Recent studies have shown that exercise significantly
decreases interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in patients with type 2
diabetes (T2D). This paper explores the effect of chronic exercise on myokines in patients with
T2D and/or obesity.

Methods:
The author searched for relevant English-language articles in PubMed. A total of 14 randomized
controlled studies were found to be eligible for this short review.

Results:
It has been observed that chronic exercise does not change brain-derived neurotrophic factor
(BDNF), irisin, and secreted protein acidic and rich in cysteine levels, whereas it decreases
TNF-α levels in patients with T2D. Combined aerobic exercise (AE) and resistance training (RT)
or sprint interval training increase insulin-like growth factor 1 (IGF-1) levels and decrease IL-6 and
IL-15 levels in patients with T2D. Combined AE and RT may also increase IL-15 levels in obese
individuals. In addition, RT alone may increase BDNF, IGF-1, and IL-7 levels in overweight individuals.
However, AE alone does not change circulating myokine levels in patients with T2D,
while it may increase myonectin levels in obese individuals.

Conclusion:
This short review demonstrated that exercise appears to have favorable effects on
some myokines in patients with T2D and/or obesity. However, it remains inconclusive due to the
heterogeneity in subject characteristics and exercise modalities.
ROCK (RhoA/Rho Kinase) Activation in Atrial Fibrillation: Molecular
Pathways and Clinical Implications
Authors: Proietti Riccardo , Giordani Andrea S. , Lorenzo Calò A. 
Published: December 2022

Abstracts:
Among the complex mechanisms of AF pathogenesis, intracellular calcium overload and
oxidative stress play a major role, both triggered by inflammatory processes. The additional basic
event taking place in AF is atrial fibrotic remodeling, again triggered by oxidative stress, which is
determined by connexins rearrangement and differentiation of fibroblasts into active collagensecreting
myofibroblasts. RhoA/ROCK system is the final pathway of a wide spectrum of molecular
effectors such as Angiotensin II, platelet-derived growth factor, connective tissue growth factor
and transforming growth factor β, that overall determine calcium dysregulation and pro-fibrotic
remodeling. Both in experimental and clinical studies, RhoA/ROCK activation has been linked to
superoxide ion production, fibrotic remodeling and connexins rearrangement, with important consequences
for AF pathogenesis. ROCK pathway inhibition may therefore be a therapeutic or preventive
target for special AF subgroups of patients.
Validation of an Interoperability Framework for Linking mHealth Apps to Electronic Record Systems in Botswana: Expert Survey Study
Authors: Ndlovu Kagiso , Mars Maurice , Scott Richard E 
Published: December 2022

Background
Electronic record (eRecord) systems and mobile health (mHealth) apps have documented potential to improve health service delivery, resulting in increased global uptake. However, their interoperability remains a global challenge hindering diagnosis, monitoring of health conditions, and data access irrespective of geographic location. Given the widespread use of mobile devices by patients and health care providers, linking mHealth apps and eRecord systems could result in a comprehensive and seamless data exchange within a health care community. The Botswana National eHealth Strategy recognizes interoperability as an issue and mHealth as a potential solution for some health care needs but is silent on how to make mHealth apps interoperable with existing eRecord systems. A literature review and analysis of existing mHealth interoperability frameworks found none suitable for Botswana. As such, it was critical to conceptualize, design, and develop an mHealth-eRecord Interoperability Framework (mHeRIF) to enhance the interoperability pillar of the Botswana National eHealth Strategy and leverage the full benefits of linking mHealth apps with other health information systems.

Objective
This study aimed to validate the developed mHeRIF and determine whether it requires further refinement before consideration towards enhancing the National eHealth Strategy.

Methods
Published framework validation approaches guided the development of a survey administered to 12 purposively selected local and international eHealth experts. In total, 25% (3/12) of the experts were drawn from Botswana, 25% (3/12) were drawn from low- and middle-income countries in sub-Saharan Africa, 25% (3/12) were drawn from low- and middle-income countries outside Africa, and 25% (3/12) were drawn from high-income countries. Quantitative responses were collated in a Microsoft Excel (Microsoft Corp) spreadsheet for descriptive analysis, and the NVivo software (version 11; QSR International) was used to aid the thematic analysis of the qualitative open-ended questions.

Results
The analysis of responses showed overall support for the content and format of the proposed mHeRIF. However, some experts’ suggestions led to 4 modest revisions of the mHeRIF.

Conclusions
Overall, the experts’ reviews showed that the mHeRIF could contribute to the National eHealth Strategy by guiding the linking of mHealth apps to existing eRecord systems in Botswana. Similarly, the experts validated an architectural model derived from the mHeRIF in support of the first mobile telemedicine initiative considered for national rollout in Botswana. The mHeRIF helps identify key components to consider before and after linking mHealth apps to eRecord systems and is being considered for use as the foundation of such interoperability in Botswana.
Village Fund and its Impact on Poverty Alleviation in Kulon Progo Regency
Authors: Oktavia Rina , Wihastuti Latri 
Published: December 2022

One of the objectives of the Village Fund is to alleviate poverty. Kulon Progo Regency is one of the regencies in at the provincial level and even national level. This study aims to 1) analyze the impact of the allocation of the village fund on village poverty in Kulon Progo Regency; 2) the strategic map of Village Fund management in Kulon Progo Regency; and 3) the Village Fund management with respect to poverty alleviation programs in Kulon Progo Regency. This study used several research methods to including the between the means, and descriptive quantitative and qualitative analysis. Results of the difference between the means test showed a significant difference in the poverty level in Kulon Progo Regency in the aftermath of the implementation of the Village Fund policy. Meanwhile, descriptive quantitative analysis results showed that 85 - 95 percent of Village Fund allocation for 2015-2017 period was on development programs, while qualitative analysis results identified differences in the management of Village Funds in Demangrejo and Kalirejo Villages. The difference in the management of the Village Fund in Kalirejo and Demangrejo Villages lay in the enthusiasm and contribution of the village community toward Village Fund management activities.
Performance Allowance, Motivation, Employees’ Work Achievement And Organizational Performance Among Goverment Employees
Authors: Mudhofar Muhammad 
Published: December 2022

This research analyzed the relationships among performance allowance, employee motivation, work achievement and organizational performance in the Ministry of Religion's Office Lumajang City. This research used a quantitative research design based on. Structural Equation Modeling (SEM) model. Research results showed insignificant direct between performance allowance and motivation, employees’ work achievement, and organizational performance. Work achievement has a direct and strongest significant influence on performance improvement in public organizations. Nonetheless, the influence of work achievement on organizational performance is mediated by a number of supporting factors, including performance allowance and motivation.
Circulating Metabolites Associated with Albuminuria in a Hispanic/Latino Population
Authors: Reynolds Kaylia M. , Lin Bridget M. , Armstrong Nicole D. , Ottosson Filip , Zhang Ying , Williams Ashley S. , Yu Bing , Boerwinkle Eric , Thygarajan Bharat , Daviglus Martha L. , Muoio Deborah , Qi Qibin , Kaplan Robert , Melander Olle , Lash James P. , Cai Jianwen , Irvin Marguerite R. , Newgard Christopher B. , Sofer Tamar , Franceschini Nora 
Published: December 2022

Background
Albuminuria is associated with metabolic abnormalities, but these relationships are not well understood. We studied the association of metabolites with albuminuria in Hispanic/Latino people, a population with high risk for metabolic disease.

Methods
We used data from 3736 participants from the Hispanic Community Health Study/Study of Latinos, of which 16% had diabetes and 9% had an increased urine albumin-to-creatinine ratio (UACR). Metabolites were quantified in fasting serum through nontargeted mass spectrometry (MS) analysis using ultra-performance liquid chromatography-MS/MS. Spot UACR was inverse normally transformed and tested for the association with each metabolite or combined, correlated metabolites, in covariate-adjusted models that accounted for the study design. In total, 132 metabolites were available for replication in the Hypertension Genetic Epidemiology Network study (n=300), and 29 metabolites were available for replication in the Malmö Offspring Study (n=999).

Results
Among 640 named metabolites, we identified 148 metabolites significantly associated with UACR, including 18 novel associations that replicated in independent samples. These metabolites showed enrichment for D-glutamine and D-glutamate metabolism and arginine biosynthesis, pathways previously reported for diabetes and insulin resistance. In correlated metabolite analyses, we identified two modules significantly associated with UACR, including a module composed of lipid metabolites related to the biosynthesis of unsaturated fatty acids and alpha linolenic acid and linoleic acid metabolism.

Conclusions
Our study identified associations of albuminuria with metabolites involved in glucose dysregulation, and essential fatty acids and precursors of arachidonic acid in Hispanic/Latino population.

Podcast
This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/CJASN/2023_02_08_CJN09070822.mp3
Gaya Kepemimpinan General Manager dalam Meningkatkan Kualitas Makanan Karyawan dengan Tetap Mempertahankan Standard Food and Beverage Cost
Authors: Arnawa I Putu , Sudarsana Ketut , Rahayu  , Amanda Anastasia , Saputra I Gede Yoga Dana 
Published: December 2022

Salah satu indikator tercapainya pemenuhan hak-hak karyawan yang baik adalah dengan diperhatikannya kualitas makanan dan minuman yang disajikan oleh pihak manajemen. Penelitian ini bertujuan untuk menganalisis dan mengidentifikasi pengaruh gaya kepemimpinan mana yang paling baik diterapkan oleh seorang General Manager dalam meningkatkan kualitas makanan karyawan (employee meal) sesuai dengan Standard Food and Beverage Cost yang berlaku. Metode penelitian ini adalah kuantitatif dengan cara mengumpulkan berbagai referensi yang ditemukan dari hotel X, buku, jurnal daring, dan internet mengenai data yang dibutuhkan, kemudian dipaparkan dalam bentuk teks secara deskriptif serta ditampilkan dalam tabel. Data dikumpulkan menjadi satu kesatuan, kemudian dianalisis dan diklasifikasi dalam rangka mencari pertimbangan. Proses analisis data dilakukan secara terperinci dengan melibatkan identifikasi data. Hasil dari penelitian ini menemukan bahwasanya persentase manajemen hotel dalam memberikan makanan yang berkualitas, baik itu sehat dan bergizi bagi karyawannya masih tergolong rendah. Adapun gaya kepemimpinan yang paling baik untuk mengatasi masalah tersebut ialah gaya kepemimpinan demokratis, dimana seorang General Manager harus mau dan mampu untuk mempertimbangkan segala macam masukan dari bawahannya dalam rangka evaluasi dan perkembangan bersama. Sekaligus, dengan adanya gaya kepemimpinan ini diharapkan General Manager sebagai pimpinan puncak dapatmemberikan solusi terbaik dengan menyesuaikan dan merencanakan budget atau anggaran operasional hotel yang sesuai, akan tetapi dengan tanpa mengurangi perhatian terhadap kesejahteraan karyawannya terutama dalam segi pemenuhan makanan dan minuman karyawan yang berkualitas.
Penataan Peraturan Daerah dengan Metode Omnibus Law: Urgensi dan Mekanisme
Authors: Helmi Helmi 
Published: December 2022

The arrangement of regional regulations in Indonesia has now become an urgent due the fact that those regulations are problematic with regards to their quantity and content. As an effort of encouraging such arrangement, this article proposes the use of omnibus law in making the regulations. Theoretically, the omnibus law is a method or technique of making regulations from which a regulation is formed in order to amend, repeal, or enact many regulations simultiniously. Such the method is worth considerations to be used in the arrangement of regulations as a way out of so many regulations, some of which are problematic in their substances. As long as the regional regulations are concerned, this method is also necessary as a response to the Job Creation Law which has already been established under the method of Omnibus Law. It is an evidence that the Job Creation Law and its implementing regulations require synchronization and harmonization in level of local regulations. The mechanism can be implemented in such a way through inventory and analysis of several regional regulations with similar content, after which they are formed and compiled into one regional regulation. Regional regulations whose contents have been merged shall be declared revoked and invalid in order to be functional in use rather than just amending or revoking some articles and inserting the new ones as in the Job Creation Law.
Abstrak
Penataan peraturan daerah menjadi perlu dilakukan seiring semakin terungkapnya berbagai permasalahan regulasi di daerah, baik berkenaan dengan jumlah maupun materi muatan. Dalam upaya mendorong penataan regulasi di daerah, artikel ini mengusulkan penggunaan metode omnibus law dalam pembentukan perda melalui bahasan urgensi dan mekanisme penggunaan omnibus law dalam pembentukan perda. Omnibus law sendiri adalah metode atau teknik dalam pembentukan peraturan perundang-undangan dengan cara membentuk satu peraturan untuk mengubah, mencabut, atau mengesahkan beberapa peraturan sekaligus. Metode ini layak dipertimbangkan untuk digunakan dalam penataan perda guna mengatasi jumlah perda yang banyak dan sebagian di antaranya bermasalah secara substansi. Dalam level perda, metode ini juga urgen dalam rangka merespons Undang-Undang Cipta Kerja yang telah terlebih dahulu dibentuk dengan metode omnibus law, mengingat Undang-Undang ini beserta peraturan pelaksanaannya membutuhkan pembenahan pada perda agar sinkron dan harmonis. Mekanisme yang dapat ditempuh adalah inventarisasi dan analisis beberapa perda yang materi muatannya sejenis atau serumpun untuk kemudian dibentuk dan dihimpun dalam satu perda. Berbagai perda yang materi muatannya telah digabung harus dinyatakan dicabut dan tidak berlaku lagi, agar memudahkan penggunaannya dibandingkan sekadar melakukan perubahan atau mencabut beberapa pasal dan menyisipkan beberapa pasal baru seperti dilakukan pada Undang-Undang Cipta Kerja.
Implementasi Demokrasi Lingkungan Hidup sebagai Upaya Mengurangi Timbulan Sampah Plastik di Lautan Indonesia
Authors: Hermawan Sapto , Budyatmodjo Winarno 
Published: December 2022

As a contributor to marine pollution, the existence of marine plastic litter can potentially disrupt sustainable marine ecosystems in the long term. This article intends to offer the implementation of environmental democracy ideas to relieve marine plastic itter. Environmental democracy is a system of government with the highest sovereignty on the people and places human interests side by side and in harmony with environmental (sustainability) interests. Environmental democracy’s idea as an effort to reduce marine plastic litter in Indonesia can be implemented through, i.e. providing reliable, up-to-date, and accessible information about marine plastic litter; providing active public participation in policies or regulations formulation; the availability of access to justice; and strengthening society’s rights to reduce marine plastic litter. These four components, even though they are read as procedural, are essential in reducing marine plastic litter because the elements of environmental democracy have not been entirely appropriately implemented at the practical level.
Abstrak
Sebagai salah satu kontributor pencemaran lingkungan laut, keberadaan sampah plastik dalam jangka panjang berpotensi mengganggu ekosistem laut secara berkelanjutan. Dalam upaya mengurangi timbulan sampah plastik di lautan Indonesia, artikel ini mendorong diadaptasi dan diimplementasikannya demokrasi lingkungan hidup. Demokrasi lingkungan hidup sendiri merupakan suatu sistem pemerintahan dengan kedaulatan (sovereignty) tertinggi pada rakyat dan menempatkan kepentingan manusia bersanding dan selaras dengan kepentingan (kelestarian dan keberlanjutan) lingkungan hidup. Dalam upaya mengurangi timbulan sampah plastik di lautan Indonesia, implementasi DLH dapat dilaksanakan dengan menempuh empat komponen, yaitu penyediaan akses atas informasi tentang sampah plastik lautan yang akurat, mutakhir, dan mudah diakses; penyediaan ruang partisipasi publik secara aktif dalam perumusan kebijakan/regulasi dalam rangka mengurangi timbulan sampah plastik di lautan; tersedianya akses pada keadilan (access to justice); dan penguatan hak-hak masyarakat dalam rangka mengurangi timbulan sampah plastik di lautan. Keempat komponen ini, sekalipun terbaca sebagai prosedural, penting dalam upaya pengurangan sampah plastik di lautan, disebabkan pada tataran empiris elemen-elemen demokrasi lingkungan hidup tersebut belum sepenuhnya terimplementasi dengan baik.
Prinsip Kehadiran Terdakwa pada Persidangan Pidana Elektronik di Masa Pandemi Covid-19: Perbandingan Indonesia dan Belanda
Authors: Ligasetiawan Edwin , Nelson Febby Mutiara 
Published: December 2022

The COVID-19 pandemic has caused changes to the criminal justice system in many countries in the world, one of which is the trial methods using electronic devices such as videoconferencing. This change has an impact on the fulfillment of the defendant’s right of presence before the court as regulated in the Indonesia Criminal Procedure Code. The presence of the defendant is one of the basic rights in a trial, which also ensures the implementation of a fair trial because it is related to the evidentiary process. In this article, the principle of the defendant’s presence in electronic criminal trials is discussed by comparing Indonesian and Dutch laws. This study demonstrates that electronic criminal trials in Indonesia are only regulated in a Supreme Court Regulation and they are in conflict with the Indonesia Criminal Procedure Code; whereas in the Netherlands, despite its regulation in the Dutch Criminal Procedure Code, the use of videoconferencing is considered a violation of the provisions of the European Convention on Human Rights. This article argues that an electronic criminal trial requires the defendant’s agreement or provision that guarantees the rights of the defendant, because this trial overrides the defendant’s right of presence before the court.
Abstrak
Pandemi covid-19 turut memengaruhi perubahan sistem peradilan pidana pada berbagai negara di dunia, salah satunya adalah metode persidangan bersaranakan alat elektronik seperti videoconference. Perubahan ini berdampak pada hak terdakwa untuk hadir di muka pengadilan, yang di Indonesia diatur dalam KUHAP. Kehadiran terdakwa ini merupakan salah satu hak dasar terdakwa dalam suatu persidangan, yang turut menjamin pelaksanaan peradilan yang adil (fair trial) karena berkaitan dengan proses pembuktian. Dalam artikel ini prinsip kehadiran terdakwa dalam persidangan pidana elektronik dibahas melalui perbandingan hukum Indonesia dan Belanda. Hasil kajian menunjukkan, sidang pidana elektronik di Indonesia hanya diatur dalam Peraturan Mahkamah Agung dan ini berbenturan dengan KUHAP; sedangkan di Belanda, sekalipun telah dituangkan dalam KUHAP, penggunaan videoconference dianggap melanggar ketentuan European Convention on Human Rights. Artikel ini berpendapat, persidangan pidana secara elektronik memerlukan persetujuan terdakwa atau ketentuan yang menjamin seluruh hak-hak terdakwa dapat dipenuhi, sebab persidangan demikian itu mengenyampingkan hak terdakwa untuk hadir di muka sidang.