bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of a modified technique of laparoscopic radical hysterectomy for cervical cancer
Authors: Yang Ni , Fan Xiang , Wang Li , Zhu Pengfeng , Xu Peizhen 
Published: September 2022

AbstractAimObjective to investigate the feasibility, safety, and short‐term efficacy of laparoscopic radical hysterectomy without uterine lifter combined with self‐locking nylon band.MethodsThe clinical data of 152 patients who underwent a laparoscopic radical hysterectomy in the Department of gynecology and oncology of Changzhou maternal and child health hospital from January 2017 to June 2020 were analyzed retrospectively, including 97 patients who used uterine lifter (traditional laparoscopic radical hysterectomy) and 55 patients who underwent operation without uterine lifter but combining with self‐locking nylon band (modified laparoscopic radical hysterectomy). The differences in operation time, intraoperative blood loss, the width of excised parauterine tissue, the length of the excised vaginal wall, postoperative pathology and short‐term prognosis between the two groups were compared and analyzed.ResultsThere were no significant differences between the two groups in operation time, intraoperative blood loss, the width of parauterine tissue, and the length of the vaginal wall (p > 0.05). There were no significant differences in the number of lymph nodes, pelvic lymph node metastasis rate and depth of cervical interstitial infiltration between the two groups (p > 0.05), the infiltration rate of lymphatic vascular space in the traditional group was higher than that in the improved group (p < 0.05).ConclusionIt is feasible and safe for laparoscopic radical hysterectomy without uterine lifter combining with a self‐locking nylon band to seal the vaginal wall. The uterine lifter may lead to lymphatic vascular space infiltration of tumor cells.
Therapeutic effects of silodosin and urapidil on underactive bladder associated with diabetic cystopathy
Authors: Yonekubo‐Awaka Saori , Tezuka Motohiro , Tatemichi Satoshi , Takeda Hiroo 
Published: September 2022

AbstractObjectivesPharmacological treatment options for underactive bladder (UAB) syndrome are limited. Urapidil is the only alpha1‐adrenoceptor (AR) antagonist that can be used for urinary disorders in women in some countries. However, no studies have directly verified the effects of alpha1‐AR antagonists on the female urethra and UAB‐like dysfunctions. We investigated the effects of silodosin (alpha1A‐AR antagonist) and urapidil (nonselective alpha1‐AR antagonist) on the voiding function in female rats with diabetes mellitus (DM).MethodsChanges in intraurethral pressure (IUP) induced by midodrine (alpha1‐AR agonist) and mean blood pressure (MBP) were continuously measured in normal female rats to verify the pharmacological profiles of the drugs. To establish a DM model, rats were administered streptozotocin (STZ; 50 mg/kg, intravenous). Eight weeks after STZ administration, drugs were subcutaneously delivered through an osmotic pump. Four weeks after drug administration, emptied bladder blood flow (BBF), intravesical pressure, and the micturition volume were measured.ResultsBoth silodosin and urapidil inhibited the midodrine‐induced increase in IUP and decreased MBP in a dose‐dependent manner. Silodosin had a more substantial effect on the lower urinary tract than on MBP. Twelve weeks after STZ administration, DM rats exhibited UAB‐like dysfunction (increased bladder capacity/bladder weight and residual volume and decreased bladder voided efficiency) and decreased BBF. Both drug treatments controlled this dysfunction.ConclusionsAlpha1‐AR antagonists induced dose‐dependent urethral relaxation in female rats. These drugs ameliorated UAB‐like dysfunction in STZ‐induced DM rats. In addition, alpha1A‐AR antagonists such as silodosin, which have limited effects on blood pressure, appear to be useful for treating UAB.
Notes on the accumulation and utilization of capital: Some theoretical issues
Authors: Nikiforos Michalis 
Published: September 2022

AbstractThis paper discusses some issues related to the triangle between capital accumulation, distribution, and capacity utilization. First, it explains why utilization is a crucial variable for the various theories of growth and distribution, and, more precisely, with regards to their ability to combine an autonomous role for demand (along Keynesian lines) and an institutionally determined distribution (along classical lines). Second, it responds to some recent criticism by Girardi and Pariboni (2019) and I explain that their interpretation of the model in Nikiforos (2013) is misguided, and that the results of the model can be extended to the case of a monopolist. Third, it provides some concrete examples on why demand is a determinant for the long‐run rate of utilization of capital. Finally, it argues that when it comes to the normal rate of utilization it is the expected growth rate of demand that matters, and not the level of demand. This insight provides a more straightforward way to link the adjustment at the micro and the macro level.
Roles and interactions of the specialized initiation factors EIF4E2, EIF4E5, and EIF4E6 in Trypanosoma brucei: EIF4E2 maintains the abundances of S‐phase mRNAs
Authors: Falk Franziska , Melo Palhares Rafael , Waithaka Albina , Clayton Christine 
Published: September 2022

AbstractTrypanosoma brucei has six versions of the cap‐binding translation initiation factor EIF4E. We investigated the functions of EIF4E2, EIF4E3, EIF4E5, and EIF4E6 in bloodstream forms. We confirmed the protein associations previously found in procyclic forms and detected specific copurification of some RNA‐binding proteins. Bloodstream forms lacking EIF4E5 grew normally and differentiated to replication‐incompetent procyclic forms. Depletion of EIF4E6 inhibited bloodstream‐form trypanosome growth and translation. EIF4E2 copurified only the putative RNA‐binding protein SLBP2. Bloodstream forms lacking EIF4E2 multiplied slowly, had a low maximal cell density, and expressed the stumpy‐form marker PAD1 but showed no evidence for enhanced stumpy‐form signaling. EIF4E2 knock‐out cells differentiated readily to replication‐competent procyclic forms. EIF4E2 was strongly associated with a subset of mRNAs that are maximally abundant in the S‐phase, and these all had decreased abundances in EIF4E2 knock‐out cells. Three EIF4E2 target mRNAs are also bound and stabilized by the Pumilio domain protein PUF9. Yeast 2‐hybrid results suggested that PUF9 interacts directly with SLBP2, but PUF9 was not detected in EIF4E2 pull‐downs. We speculate that the EIF4E2‐SLBP2 complex might interact with its target mRNAs, perhaps via PUF9, only early during G1/S, stabilizing the mRNAs in preparation for translation later in S‐phase or in early G2.
Oral surgery waiting lists at an Australian university dental school
Authors: Arora Sitanshu , Ngu Anthony C. S. , Reher Peter 
Published: September 2022

AbstractObjectiveThe aim of this study was to investigate the waiting times experienced by patients referred to an Australian University oral surgery clinic over a 2‐year period.Materials and methodA single‐centre retrospective study was conducted to determine the waiting times for oral surgery services at the Griffith University postgraduate clinic. The first 233 patients were selected out of a total of 587 randomised patients and data collected regarding referral sources, procedures undertaken and the number of days from referral to consultation, then to treatment collected from the clinic's management software.ResultsOf the 233 referrals, 121 were female (52%) and 112 male (48%). Many patients were between 20 and 29 years representing approximately 40% (n = 93) of the sample. Analyses of referred patients showed that a significant number of public (i.e. non‐private‐paying) patients (73%, n = 170) were treated in the study period. Most patients waited only 1–2 weeks to be seen for a consultation from date of referral and treatment from date of consultation. Nearly half (49.7%, n = 116) were treated within 2 months of being referred. Once the patient was referred, the overall mean waiting time was 44 days from referral to treatment. Treatment comprised of either procedures undertaken under local anaesthesia (LA) (76.7%, n = 179) or consultations only with patients either declining treatment, deemed not in need of surgical intervention, or referred for more advanced management such as the need for general anaesthesia (23.3%, n = 54). Surgical removal of third molars (36.1%, n = 84) was the most common reason for referral.ConclusionA variety of minor oral surgery procedures can be provided under local anaesthesia with acceptable accessibility and shorter public oral surgery waiting lists.
Knee Reconstruction Using3D‐PrintedPorous Tantalum Augment in the Treatment of Charcot Joint
Authors: Hua Long , Lei Pengfei , Hu Yihe 
Published: September 2022

BackgroundCharcot joint disease is a rare neurogenic lesion of the joint characterized by progressive joint destruction with dislocation or subluxation. However, whether a joint replacement should be performed for severe joint damage is controversial.Case presentationThis paper reports a case of severe Charcot joint disease with a large bone defect that was treated with arthroplasty assisted by a customized 3D‐printed porous tantalum. The patient was admitted to the hospital with a 9‐year history of bilateral knee pain that had aggravated in the past 2 months. Radiography showed osteogeny and sclerosis in both knees, free bone fragments, heterotopic ossification, new bone, and osteophyte formation, irregular margins, apparent narrowing of joint space, and severe joint damage (Anderson Orthopedic Research Institute classification type III). Based on the present illness, history, imaging, and laboratory examination, Charcot joint disease was confirmed. Conservative treatment has been reported in the literature. There are limited reports on the surgical treatment of severe Charcot joint disease. We followed up with the patient for a year after the operation, and the imaging and clinical evaluation results were good. Postoperative X‐ray examinations showed good alignment of force lines, good joint space, and no evidence of loosening. The patient was mobile and did not need crutches.ConclusionsThrough accurate surgical evaluation and preparation of 3D‐printed porous tantalum implants, severe AORI classification type III Charcot joint disease can effectively restore the range of motion of the knee joint, the lower limb alignment, and finally achieve good functional results of walking without crutches.
Trans‐right atrial access to the left ventricle for catheter ablation of ventricular tachycardia in patients with mechanical aortic and mitral valves
Authors: Gökdeniz Teyyar , Karavelioglu Yusuf , Akgün Taylan , Çelik Muhammet Cihat 
Published: September 2022

AbstractThe presence of mechanical heart valves in both aortic and mitral positions is a significant limitation for traditional left ventricular (LV) access, including retrograde transaortic and/or antegrade interatrial transseptal routes. We present a case of successful catheter ablation for ventricular tachycardia via a traditional transfemoral venous approach, which involves direct puncture of the inferior and medial aspect of the right atrium adjacent to the posteroseptal process of LV (PSPLV). Percutaneous trans‐right atrial access to the left ventricle appears to be a safe and feasible method for catheter ablation of ventricular tachycardia in patients with mechanical aortic and mitral valves.
Diagnostic progression to schizophrenia: A nationwide cohort study of 11 170 adolescents and young adults with autism spectrum disorder
Authors: Hsu Tien‐Wei , Chu Che‐Sheng , Tsai Shih‐Jen , Hsu Ju‐Wei , Huang Kai‐Lin , Cheng Chih‐Ming , Su Tung‐Ping , Chen Tzeng‐Ji , Bai Ya‐Mei , Liang Chih‐Sung , Chen Mu‐Hong 
Published: September 2022

AimsPrevious studies have suggested an increased risk of developing schizophrenia later in life in children with autism spectrum disorder (ASD). This study aims to investigate the diagnosis stability and the potential predictors for progression to schizophrenia in ASD.MethodsWe recruited 11 170 adolescents (10–19 years) and young adults (20–29 years) with ASD between 2001 and 2010. They were followed up to the end of 2011 to identify newly diagnosed schizophrenia. The Kaplan–Meier method and Cox regression with age as a time scale were employed to estimate incidence rates and the significance of candidate predictors.ResultsThe progression rate from ASD to schizophrenia was 10.26% for 10 years of follow‐up. Among 860 progressors, 580 (67.44%) occurred within the first 3 years after a diagnosis of ASD. The identified predictors were age (reported as hazard ratio with 95% confidence interval: 1.13; 1.11–1.15), depressive disorder (1.36; 1.09–1.69), alcohol use disorder (3.05; 2.14–4.35), substance use disorder (1.91; 1.18–3.09), cluster A personality disorder (2.95; 1.79–4.84), cluster B personality disorder (1.86; 1.05–3.28), and a family history of schizophrenia (2.12; 1.65–2.74).ConclusionMore than two‐thirds of the progressors developed schizophrenia within the first 3 years. Demographic characteristics, physical and psychiatric comorbidities, and psychiatric family history were significant predictors of progression.
Internet searching on the head louse in the UK since the COVID‐19 pandemic
Authors: Walker Mark David , Sulyok Mihály 
Published: September 2022

AbstractBackgroundWide‐ranging restrictions on social and educational activities were imposed in 2020 in response to the COVID‐19 pandemic. These likely influenced the population dynamics of the head louse. Close physical contact between human hosts is required for transmission of this ectoparasite.MethodPre‐ and post‐pandemic internet interest in the head louse in the UK was compared using Google Trends data from March 2017 to March 2022 and modeling using the Meta Prophet package. The influence of school holidays and school attendance was also investigated.ResultsThere was a sharp decline in internet searching of the term “head louse” from March 2020 onwards coinciding with COVID‐19 restrictions, and a large difference between pre‐ and post‐pandemic search volumes. No influence of school holidays or attendance on internet searching on the head louse was found.ConclusionThe results suggest pandemic restrictions have had a large effect on head louse incidence.
Understanding How a New Hachimoji Nucleobase Alters Photodynamics of Genetic Building Blocks†
Authors: de Vries Mattanjah S. 
Published: September 2022

AbstractThis article is a highlight of the paper by Krul et al. in this issue of Photochemistry and Photobiology. It describes the excited state dynamics of 5‐aza‐7‐deazaguanine (5N7CG), which has recently been proposed as an alternative nucleobase. Upon UV absorption to the lowest energy 1ππ* state, 5N7CG returns to the electronic ground state an order of magnitude more slowly than guanine with a corresponding greater fluorescence quantum yield. These findings are significant because they suggest that 5N7CG is less UV photostable than its canonical nucleobase equivalent, which would have been a selective disadvantage in prebiotic conditions.
Comprehensive prediction of plant cytoplasmic and apoplastic effectors underlying Erwinia psidii pathogenicity
Authors: Alves Francisco Henrique Nunes da Silva , Pereira Isadora Cristófoli , dos Santos Samuel Alves , Monteiro Ana Leticia Rocha , Vidigal Pedro Marcus Pereira , Alfenas Acelino Couto , Badel Jorge Luis 
Published: September 2022

AbstractErwinia psidii (Eps) is the causal agent of emerging diseases of eucalypt and guava; however, the mechanisms underlying its pathogenicity are not fully understood. Here, we predicted factors involved in the ability of Eps to cause disease on its host plants. For that, the genomes of four Eps strains exhibiting different virulence on eucalypt were sequenced, and hrp/hrc genes coding for the type III secretion system (T3SS), effectors injected into the plant cell cytoplasm through the T3SS (T3SEs) and their plant subcellular localizations, as well as proteins deployed to the host apoplast, were predicted. It was found that Eps possesses a complete hrp/hrc gene cluster based on comparison with Erwinia amylovora. A total of 18 T3SEs were predicted, 11 of which were shared among all strains, none were exclusive to any strain and seven were absent in at least one strain. No sequence variation among strains was found for five T3SE candidates whereas extensive variation was found for six, suggesting the latter may be determinants of virulence differences. The T3SE candidates are predicted to target the plant cell nucleus, cytoplasm, mitochondrion, chloroplast and peroxisome. The predicted apoplastic effector repertoire common to all four strains was over‐represented in proteins of unknown functions or predicted to possess enzymatic activities, among which the most abundant were oxidoreductases and peptidases. Proteins with lytic transglycosylase activity were predicted in strain‐specific apoplastic effector repertoires. These results provide an important framework for future research aimed at uncovering the factors underlying Eps pathogenicity.
Understanding policy influence in hybrid regimes: Insights from a qualitative study of policy advice in Ukraine and Moldova
Authors: Marchevska Denitsa , Steen Trui 
Published: September 2022

AbstractThe growing complexity of policy challenges has necessitated the reconsideration of the classic state‐centered deliberative models and their replacement with more inclusive concepts like that of the policy advisory system. Still, although the asymmetrical power distribution across different advisors has been recognized, the question of why some actors are able to exercise greater influence than others has received relatively little systematic attention. This paper addresses this question while focusing its attention on Ukraine and Moldova in a departure from the literature's empirical preoccupation with Western liberal democracies. Through a qualitative analysis of 45 semi‐structured interviews, the paper empirically tests the theoretical conceptualization, which explains policy influence as a result of the interaction of content, context, demand and supply factors. The findings illustrate the usefulness of the framework as a theoretical tool beyond Western democratic systems. However, they also indicate the need for conceptual refinements accounting for the significant role played by internationalization, personalization, informality, politicization and political polarization in advisory dynamics in hybrid regimes like those in Ukraine and Moldova in order for advisory scholarship to overcome its Western bias.
Contract as a Transfer of Ownership and Public Justification: Two Models
Authors: Zanitelli Leandro Martins 
Published: September 2022

AbstractThis article deals with Peter Benson’s claim that, unlike rival approaches such as promissory morality and the economic analysis of law, the theory of contract as transfer of ownership offers a public basis of justification for the coercive practice of contracts. The article points out that this claim can be understood in two ways, each corresponding to a model of public justification, namely, the avoidance model and the hermeneutic model. My ambition is to show that the avoidance model is beset by certain difficulties not encountered by the hermeneutic model, suggesting that the hermeneutic model is a more promising interpretation of the idea of public justification as applied to contracts.
W. E. B. Du Bois and the EVOLUTION OF ‘RACE’
Authors: Shaw Stephanie J. 
Published: September 2022

AbstractThis essay situates the major works of W.E.B. Du Bois and some of his minor work between the 1880s and 1940 in the historical context of black people's writing about race since the eighteenth century. In offering examples of the evolution of black thinking and writing on this topic, it views Du Bois's work in the context of Moral and Ethical Philosophy (rather than the more obvious History, Sociology, and Political Economics) in order to reveal his efforts as a disruption, deliberately designed to shift the discussions of race and race relations from defense to offense, which he did most explicitly and profoundly in Dusk of Dawn (1940) but had been doing much more subtly throughout his scholarly career.
Injury characteristics and circumstances of firearm trauma: Assessing suicide survivors and decedents
Authors: Karnick Aleksandr T. , Bond Allison E. , Kaufman Elinore J. , Anestis Michael D. , Capron Daniel W. 
Published: September 2022

AbstractIntroductionDespite representing fewer than 5% of suicide attempts, firearms account for over half of deaths. Yet there is little clinical information regarding firearm attempts, particularly survivors. We assessed clinical factors differentiating firearm suicide survivors from decedents, firearm attempters from other methods, and firearm attempters from similarly injured trauma patients.MethodsWe used clinical data from the National Trauma Data Bank (2017) to assess firearm suicide attempts using cross‐sectional and case–control designs. We used logistic and multinomial regression to compare groups and assess firearm type and discharge destination.ResultsOlder age, being uninsured, and injury location were associated with increased mortality among firearm attempters. Older age, White race, male sex, and being uninsured were associated with firearm attempts. Major psychiatric disorders were associated with firearm attempts and using a rifle or shotgun. Major psychiatric disorders, female sex, and smoking were associated with psychiatric discharge. Black and other race were associated with law enforcement discharge, and Black race was associated with lower odds of psychiatric discharge. Uninsured patients had lower odds of discharge to long‐term care, psychiatric, or rehabilitation facilities.ConclusionsThis study identifies factors associated with firearm suicide and includes indicators of disparities in health services for patients at high risk of suicide death.