bluuebunny/crossref_metadata_2025_split huggingface dataset:
Certain aspects of radiomics and radiogenomics in glioblastoma: what the images hide?
Authors: Maslov N. E. , Trufanov G. E. , Efimtsev A. Yu. 
Published: July 2022

Radiogenomics is a novel and promising field connecting a variety of imaging possibilities with various genomic events. Advances in genomics provided by the Cancer Genome Atlas and Human Genome projects made it possible to integrate this information with imaging phenotypes of malignant brain tumors for a more detailed understanding of their biology. Radiomics, in turn, lies at the intersection of radiology, computer science and mathematical statistics. Unlike radiogenomics, it does not focus on the specific relationship between the radiophenotype and tumor genotype, but rather identifies the analysis methodology. With its help, quantitative features are extracted from medical images, establishing patient’s genotype-phenotype correlation. This contributes to the risk stratification and patient management. The article discusses some topical aspects of radiomics and radiogenomics of glioblastomas and their application in neurooncology.Previously, several groups of researchers showed the relationship between visualization features of glioblastomas and the prognosis of the course of the disease.One of the modern problems of radiomics is the search for imaging features that can serve as key prognostic markers for risk stratification of patients with glioblastomas using machine learning tools.Thus, the prospects for the development of radiomics and radiogenomics methods include predicting patient survival, differential diagnosis of glioblastomas, determining the degree of malignancy, identifying mutations and amplifications, detecting tumor progression, pseudoprogression, etc.
MODELAMIENTO DE UN SISTEMA FOTOVOLTAICO CONECTADO A LA RED CONSIDERANDO LA VARIACIÓN DE IRRADIANCIA SOLAR EN HOMER PRO
Authors: Figueroa Guerra Danner Anderson , Culqui Tipan Javier Fernando , Núñez Verdezoto Marlon Daniel , Cruz Panchi Omar Danilo 
Published: July 2022

En la presente investigación surgió la necesidad de utilizar herramientas didácticas que permitieran conocer la mejor optimización de un sistema fotovoltaico para el abastecimiento de las cargas de una bananera. En correspondencia a lo anterior, este estudio presenta un modelo y simulación de un sistema conectado a la red, considerando la variación de la irradiancia solar. En primera instancia, se utilizó el instrumento piranómetro en la zona a estudiar. Luego se consideró las cargas de la bananera, para luego hacer uso de la herramienta HOMER Pro para hallar la mejor viabilidad del sistema fotovoltaico con sus algoritmos de optimización. Para su validación se utilizó otros algoritmos de modelos matemáticos realizados en Matlab/Simulink, estableciendo la potencia del sistema, el costo nivelado de energía ($/kWh), como también el voltaje (V), corriente (A) y potencia (W) tanto del panel solar como la energía que sale a la carga, además, se determinó el punto de máxima transferencia de potencia (MPPT) del sistema. Por último, se evaluó el payback del modelamiento para conocer el tiempo de retorno de la inversión del sistema.
Specific activity and features of vertical migration of strontium-90 in the peat bog of the Murmansk region
Authors: Lukoshkova A. , Yakovlev E. , Orlov A. 
Published: July 2022

The peatlands of the Arctic territories are repositories of radioactive contaminations. The physicochemical properties, specific activity and features of vertical migration of 90Sr in the peat profile of the Murmansk region have been studied. A correlation matrix was compiled according to the studied indicators. The factor that determines the localization of 90Sr in peat has been established. The sources of isotope for the region were determined.
The reaction of the peat medium is acidic (4.2 ≤ pHwater ≤ 4.9; 3.6 ≤ pHsalt ≤ 4.1). The ash content of peat is medium and high (5.2 % ≤ Ash ≤ 28 %). The share of organic matter in the peat profile is more than 70 %. The upper part of the profile is saline (soluble salts>0.3%). The share of carbonates in the peat profile is insignificant (0.42–0.83 %).
90Sr activity (0.55–7.7 Bq/kg) was recorded in each peat sample. The activity of the technogenic radionuclide is below the established permissible norm and within the range typical for all Russian soils. The 90Sr isotope is localized in the upper layers of the profile and at a depth of more than 16 cm. The localization of 90Sr in peat layers is due to the content of water-soluble salts (r = 0.85). The main sources of the isotope for the Murmansk region are past global fallout from nuclear tests, the Chernobyl accident and current local fallout from nuclear fuel facilities.
Government Policy Analysis to Develop the Krian-Manyar-Gresik Toll in order to Reduce Traffic Jam using A Dynamic System Approach
Authors: Sukma Dwi , Nugraha Isna , Rahmawati Nur , Syamsiah Yuliatin Ali , Alfani Ahmad Mujaddid 
Published: July 2022

Infrastructure development in an area, including the construction of toll roads, is aimed at developing a region and increasing the economy of the region. The construction of the toll road which is connected from Krian-Manyar-Gresik is carried out to facilitate traffic connecting the two cities. Traffic jams often occur at the link between the two cities. Congestion that occurs is usually caused by an increase in the volume of vehicles. Therefore, the construction of a toll road connecting the two cities is the best alternative. This research aimed to know government policies effectiveness in the construction of this toll road. The method used in this research is to use a dynamic system approach. From the results of the traffic simulation model design, it is found that the construction of toll roads is considered very influential and can be a way out of congestion problems. This is due to a decrease in the degree of saturation of congestion and although there is an increase from year to year, it is only slightly and not too significant. So the researchers suggest to continue the planned toll road construction project.
Efficient Water Softening in Heavy Oil Steamflood Operations
Authors: Prakash Prakhar , Concienne Reid , Demayo Trevor , Towne Kirsten 
Published: July 2022

Summary
Pigging of once through steam generators (OTSGs) has indicated various types of scales, the most predominant of these being silicates of hardness causing ions. It was noted that scaling propensity can potentially go up with higher steam quality (SQ) as the reject stream gets concentrated with ions. However, models suggested that there are benefits of higher SQ in enhancing fuel savings (8%) and electricity savings (2%) when SQ was increased by 20%. The challenges of higher SQ were noted in terms of increased scaling tendency and therefore the need for improved softening. In Field D, the service cycle, the backwash cycle, and the brining cycle were optimized leading to a gain in throughput and reduction in salt consumption. Service cycle improvement gained 30 to 130% in throughput between two regenerations, backwash cycle improvement by fluidizing the bed to nearly 35% helped gain 10% in throughput, and reduction of brining cycle from 75 to 48 minutes helped reduce salt consumption by 56% without impacting the throughput. In Field B, a 6-month pilot revealed that shallow shell resins where ion exchange is more efficient due to inert core (better intraparticle diffusion control) can enhance the throughput by 30 to 80% and simultaneously reduce the number of regenerations by 15 to 30%. Resin fouling is still a major challenge to contend with as oil can foul the resin and throughput can decline by 0.5 to 3 folds. In a plant operation, where there are multiple softener and brine vessels, there is a need to optimize them as a system. Reliability, availability, and maintainability (RAM) models are used in Field C to (a) address equipment configuration optimization with impact on capital capacity expansion project scope, (b) understand how net soft water delivery capacity was affected by increases in inlet hardness, and (c) assess through a comparison scenario if the large cost of addressing the valve issue in an upstream nutshell filter was worth the lost production opportunity related to unplanned downtime.
A Blockchain-assisted Lightweight Anonymous Authentication Scheme for Medical Services in Internet of Medical Things
Authors: Wu Shu , Zhang Aiqing , Chen Jindou , Peng Guangyu , Gao Ya 
Published: July 2022

Abstract
Internet of Medical Things (IoMT) enable physicians to provide precise care over the Internet for registered patients anywhere, bringing convenience to people’s everyday life. Considering the importance of patient’s privacy in IoMT, data security between patients and medical servers should be protected. Therefore, the authentication of identity and the agreement of a shared secret key are particularly important. In this work, we propose a lightweight anonymous authentication scheme between patients and medical servers in IoMT. We combine blockchain technology with biometric technology in order to form a shared session secret key. It can protect the privacy of patients through mutual authentication between patients and servers. Afterwards, the formal analysis of BAN logic shows that our scheme is secure. Non-formal analysis shows that our scheme achieves designed security objectives. Finally, we implement the cryptography primitives to verify our scheme. Comprehensive comparative experiments show that our proposed scheme achieves a better performance in both computation and communication efficiency.
Optimal Performance Evaluation of Localization of Sensor Nodes in Wireless Sensor Networks
Authors: Gupta Akanksha , Singh Umang 
Published: July 2022

Abstract
Wireless Sensor Networks are a collection of numerous nodes which contain tiny devices having low power and work with minimal cost. In such a network, the functioning of these nodes plays a very important role to sense data and also forward the sensed data to the target observer. For segregation of nodes in effective locations, there is a need to localize these nodes by combining location information with the sensed data for tracking and monitoring of malicious nodes, goods tracking etc. The approaches towards localization may be classified as range-free or rangebased, both having their own pros and cons. This paper presents a discussion on different localization approaches, followed by simulation results of localization using lognormal shadowing model for distance estimation and trilateration for location computation. The results depict the individual impacts of node density and area of sensed region on the localization error. The approach used is cost effective, since it uses loss in received power for distance computation and hence there is no cost overhead for additional hardware.
TTC22 promotes m6A-mediated WTAP expression and colon cancer metastasis in an RPL4 binding-dependent pattern
Authors: Deng Dajun , You Abin , Tian Wei , Yuan Hongfan , Gu Liankun , Zhou Jing 
Published: July 2022

Abstract
WTAP, an essential component of the RNA N-6-methyladenosine (m6A) modification complex, guides METLL3-METLL14 heteroduplexes to target RNAs in the nuclear speckles of mammalian cells. Here, we show that TTC22 is widely coexpressed with WTAP and FTO in many human tissues by mining Genotype-Tissue Expression (GTEx) datasets. Our results indicate that the direct interaction of TTC22 with 60S ribosomal protein L4 (RPL4) promotes the binding of WTAP mRNA to RPL4, enhances the stability and translation efficiency of WTAP mRNA, and consequently increases the level of WTAP protein. Also, WTAP mRNA itself is an m6A target and YTHDF1 is characterized as an essential m6A binding protein in WTAP mRNA. TTC22 triggers a positive feedback loop between WTAP expression and WTAP mRNA m6A modification, leading to an increased m6A level in total RNA. The knockdown of RPL4, WTAP, or YTHDF1 expression diminishes the TTC22-induced increase in the m6A level of total RNA. Thus, TTC22 caused dramatic expression changes in genes related to metabolic pathways, ribosomal biogenesis, the RNA spliceosome, and microorganism infections. Importantly, TTC22 upregulates the expression of SNAI1 by increasing m6A level and thus promotes lung metastases of colon cancer cells in mice. In conclusion, our study showed that TTC22 upregulates WTAP and SNAI1 expression, which contributes to TTC22-induced colon cancer metastasis.
If postoperative radiotherapy seemed to have survival benefit in rectal cancer with pT1-3N1M0 of patients undergoing primary surgery in the TME era
Authors: Chen Jinhu , Ye Qing , Huang Feng 
Published: July 2022

Abstract
Purpose At present, for some patients with stage III rectal cancer without neoadjuvant therapy before operation, NCCN guidelines still recommend routine postoperative adjuvant radiotherapy and chemotherapy. This study aimed to evaluate the value of postoperative radiotherapy in patients with low-risk disease (pT1-3N1M0) who did not receive preoperative neoadjuvant therapy in the TME era.Methods Patients with pT1-3N1M0 rectal cancer, who undergone radical surgery for initial treatment and adjuvant chemotherapy , were recruited retrospectively from the SEER database(2004‐2016) . A propensity score model was utilized to balance baseline covariates. Results Of the 2012 included patients, 1384 patients received adjuvant chemo-radiotherapy (radio group) and the remaining 718 patients did not, only for chemotherapy alone (no-radio group). There was no significant difference in cancer-specific survival between patients who received adjuvant radiotherapy or not (Log Rank test X ²= 2.372, P=0.124) in the overall sample. In the propensity score-matched cohort, adjuvant radiotherapy also did not improve cancer-specific survival. The subgroup analysis showed that the number of positive lymph nodes equal to 3 and the tumor size larger than 50mm subgroup combined with postoperative adjuvant chemotherapy could improve tumor specific survival rate, while other cases could not benefit from postoperative radiotherapy.Conclusion For all pT1-3N1M0 patients, who without neoadjuvant therapy before operation, radiotherapy in addition to postoperative adjuvant chemotherapy does not significantly improve survival. The number of nodes positive as 3 and tumor size > 50mm may be the screening indicators for postoperative adjuvant radiotherapy.
The effects of genistein supplemented before or after irradiation on DNA injury in human lymphocytes in vitro
Authors: Dobrzyńska Małgorzata M. , Gajowik Aneta 
Published: July 2022

Abstract
Purpose. The study aimed at the investigation if application of genistein (GEN) at different time prior or past irradiation may avert or reduce the induced by irradiation injury of DNA in human lymphocytes. Materials and Methods. The isolated lymphocytes were exposed to X-irradiation (0.5; 1 Gy). GEN (1 µM/ml; 10 µM/ml) was appended to attempts at various times prior or past irradiation (1 h prior, immediately prior, immediately past, 1 h past). We joined each X-rays dose with each GEN dose. After 1h of incubation DNA damages were examined using Comet assay. Results. Combination of 1 µM/ml of GEN given 1 h before irradiation with low or high dose markedly decreased induced by irradiation DNA injury. Higher dose of GEN applied immediately before or after irradiation markedly extended the frequency of DNA injury generated by irradiation. The result of application 1 µM/ml GEN 1 h after irradiation was not significantly different compared to control. The effect of 1 Gy + 10 µM/ml GEN was not significantly lower compared to each agent alone.Conclusions. Only a very low concentration of GEN was applied before irradiation, it may be considered as a potential radiomitigator/radioprotector. High doses of GEN work as a radiosentitizer and may potent the effects of radiotherapy.
The Spectrum of Imaging Manifestations of Gorham–Stout Disease
Authors: Lee Yuna , Lee Seunghyun , Hur Saebeom , Jeong Yun Soo , Suh Dong In , Moon Jangsup , Kim Man Jin , Choi Young Hun , Cheon Jung-Eun 
Published: July 2022

Abstract
Background
To describe the radiological features of Gorham–Stout disease (GSD) as evaluated using plain radiography and dynamic contrast-enhanced magnetic resonance lymphangiography (DCMRL) imaging techniques.
Methods
Clinical and conventional imaging data were retrospectively reviewed for 15 patients with GSD between January 2001 and December 2020. After December 2018, DCMRL examinations were performed for lymphatic vessel evaluation in patients with GSD and reviewed in four patients.
Results
The median age at diagnosis was 9 years (range: 2 months–53 years). The clinical manifestations were dyspnea in seven patients (46.7%), sepsis in 12 (80.0%), orthopedic problems in seven (46.7%), and bloody chylothorax in seven (46.7%). The common sites of osseous involvement were the spine (73.3%) and pelvic bone (60.0%). Among the non-osseous involvements, peri-osseous infiltrative soft-tissue abnormalities adjacent to the area of bone involvement were the most common (86.7%), followed by splenic cysts (26.7%) and interstitial thickening (26.7%). DCMRL demonstrated weak central conducting lymphatic flow in two patients with abnormal giant tortuous thoracic ducts and no flow in one patient. All patients who underwent DCMRL in this study presented with altered anatomical lymphatics and functional flow with collateralization.
Conclusion
DCMRL imaging and plain radiography are very useful for determining the extent of GSD and are essential for diagnosis. DCMRL is an essential imaging tool for the visualization of abnormal lymphatics in patients with GSD, which helps in further treatment. Therefore, in patients with GSD, it is necessary to obtain not only plain radiographs but also MR and DCMRL images.
Terahertz Wave Excitation by Nonlinear Coupling of Intense Laser Field with Magnetized Plasma
Authors: Hassan Munther B. , Abd-Ali Ibtisam Jaafer , Mahdi Wissam H. , Alkhayatt Adel H.Omran 
Published: July 2022

Abstract
In this article, the plasma wave density is playing vast role firstly to generate a coherent THz wave then enhancing its stability and increasing its intensity. Due to the relativistic increase of electron mass, the relativistic self-focusing of a right circular polarized laser beam (RCP) inside magnetized plasma will occur which leads to raising the laser power to enough limits for exciting the terahertz wave. By fulfilling the energy-momentum conservation conditions, a terahertz wave frequency at the difference between the laser pump wave frequency and plasma wave frequency is obtained. More stabilization and higher power (reaching tens of gigawatts) of terahertz field amplitude have been observed whenever the plasma frequency is increased. Better results are recorded at high THz frequency (5 THz) compared with low THz frequency (0.5 THz).
Digital Learning Designs in Occupational Therapy Education: A Scoping Review
Authors: Hwang Na-Kyoung , Shim Sun-Hwa , Cheon Hye-Won 
Published: July 2022

Abstract
Background: Digital learning is a rapidly advancing method for teaching and learning in professional health education. Although various digital learning designs have been tried in OT education, studies on digital learning designs are still limited. Methods: We conducted a scoping study to aims to identify the digital learning designs used in occupational therapy (OT) education and review the effectiveness, learner perceptions, clinical skills integrated, and technology-based learning strategies used to facilitate learning. Four databases were searched using subheadings and terms relating to digital learning, occupational therapy and education. The included studies were mapped according to the types of digital learning design, subject, key clinical skills, and outcomes. Results: Twenty-two studies were included in this review, most of which were qualitative, observational, or mixed studies of the two designs. The digital learning designs identified in OT education were flipped, blended, hybrid, and distance learning, including e-learning and massive open online courses (MOOC). Among the components of clinical skills, clinical reasoning and procedural knowledge were the most integrated into digital learning, and covered various OT subjects. Digital learning designs were reported to be equivalent to or more effective than the traditional face-to-face (F2F) class in learning outcomes of knowledge and skill acquisition, enhancing learning participation, reflection, and collaboration between learners. Various technologies have been used to promote synchronous or asynchronous active learning, providing learning strategies such as thinking, reflection, discussion, peer learning-group activity, and gamifying online learning. Conclusions: In OT digital learning, appropriate learning subjects, the arrangement of clinical skill components that can be well integrated into digital learning, and the selection of appropriate technologies for effective learning are important. The results should be confirmed within an experimental study design.
Enhancing the water cycle restoration of LID practices considering climate change: A case study on permeable pavement planning by an iterative MCDM model
Authors: Chae Seung Taek , Chung Eun Sung , Jiang Jiping 
Published: July 2022

Abstract
Low-impact development (LID) measures have been popularly installed in many developed countries for urban runoff control and treatment. However, precipitation and temperature changes driven by climate change lead to water cycle deterioration, especially in urban watersheds. It is important to optimize LID implementations aimed at rehabilitating the water cycle in urban watersheds for climate change adaptation. To enhance the water cycle restoration of LID practices according to climate change, an iterative multi-criteria decision making (MCDM) approach is proposed to allocate permeable pavement areas while considering newly released climate change scenarios. Daily precipitation, maximum temperature, and minimum temperature were considered for the future climate environment estimated using 15 coupled model intercomparison project (CMIP) 6 general circulation models (GCMs) according to two scenarios for shared socioeconomic pathways (SSPs). The hydrological impact on the permeable pavement application was simulated using the Storm Water Management Model (SWMM). The priority of each microlevel unit for permeable pavement was robustly determined using combined MCDM methods. According to the derived priorities, every unit area of permeable pavement was iteratively allocated until it converged to the initially planned total permeable pavement area. The results of this study confirmed that different climate predictions for each GCM can affect the priority results. Furthermore, it was confirmed that the iterative process used in this study improved the water cycle restoration more efficiently than when allocating at once according to priority. The results of this study can help determine the robust LID capacity for each sub-watershed under limited resources.