bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative assessment of radiotherapy-induced myocardial damage using MRI: A systematic review
Authors: Omidi Alireza , Weiss Elisabeth , Trankle Cory R. , Rosu-Bubulac Mihaela , Wilson John S. 
Published: September 2022

Abstract
Purpose: To determine the role of magnetic resonance imaging (MRI)-based metrics to quantify myocardial toxicity following radiotherapy (RT) in human subjects through review of current literature.
Methods: 21 MRI studies published between 2011-2022 were identified from available databases. Patients received chest irradiation with/without other treatments for various malignancies including breast, lung, esophageal cancer, Hodgkin’s, and non-Hodgkin’s lymphoma. In 11 longitudinal studies, the sample size, mean heart dose, and follow-up times ranged from 10-81 patients, 2.0-13.9 Gy, and 0-24 months after RT (in addition to a pre-RT assessment), respectively. In 10 cross-sectional studies, the sample size, mean heart dose, and follow-up times ranged from 5-80 patients, 2.1-22.9 Gy, and 2-24 years from RT completion, respectively. Global metrics of left ventricle ejection fraction (LVEF) and mass/dimensions of cardiac chambers were recorded, along with global/regional values of T1/T2 signal, extracellular volume (ECV), late gadolinium enhancement (LGE), and circumferential/radial/longitudinal strain.
Results: LVEF tended to decline at >20 years follow-up and in patients treated with older RT techniques. Changes in global strain were observed after shorter follow-up (13±2 months) for concurrent chemoradiotherapy. In concurrent treatments with longer follow-up (8.3 years), increases in left ventricle (LV) mass index were correlated with LV mean dose. In pediatric patients, increases in LV diastolic volume were correlated with heart/LV dose at 2 years post-RT.
Regional changes were observed earlier post-RT. Dose-dependent responses were reported for several parameters, including: increased T1 signal in high-dose regions, a 0.136% increase of ECV per Gy, progressive increase of LGE with increasing dose at regions receiving >30 Gy, and correlation between increases in LV scarring volume and LV mean/V10/V25 Gy dose.
Conclusion: Global metrics only detected changes over longer follow-up, in older RT techniques, in concurrent treatments, and in pediatric patients. In contrast, regional measurements detected myocardial damage at shorter follow-up and in RT treatments without concurrent treatment and had greater potential for dose-dependent response. The early detection of regional changes suggests the importance of regional quantification of RT-induced myocardial toxicity at early stages, before damage becomes irreversible. Further works with homogeneous cohorts are required to examine this matter.
Outer nuclear layer recovery as a predictor of visual prognosis in type 1 choroidal neovascularization of neovascular age-related macular degeneration
Authors: Lee Seungheon , Kim Kyung Tae , Kim Dong Yoon , Chae Ju Byung , Seo Eoi Jong 
Published: September 2022

Abstract
To investigate the changes in outer nuclear layer (ONL) thickness during anti-vascular endothelial growth factor (VEGF) treatment in type 1 choroidal neovascularization (CNV) and its impact on vision. Type 1 CNV eyes (n = 94) were retrospectively compared to normal control eyes (n = 35). Along with best-corrected visual acuity (BCVA), the location of CNV, foveal ONL thickness, and subretinal fluid height were measured using optical coherence tomography (OCT) and analyzed. Visual outcome and OCT biomarkers were compared. As a result, the CNV group had thinner foveal ONL and worse BCVA compared to the control group. ONL thickness recovered partially along with visual improvement following 3 monthly initial loading doses of aflibercept injections, and it correlated with the final BCVA during the 1-year follow-up. Eyes achieved foveal ONL recovery over + 10 µm had lower subfoveal CNV (45.5%) and showed better visual outcomes than eyes with stationary ONL or suboptimal ONL recovery (76.0%, p = 0.012). In conclusion, type 1 CNV eyes that recovered foveal ONL thickness at initial loading of anti-VEGF demonstrated good final visual outcome during the 1-year follow-up. Monitoring the foveal ONL thickness during early anti-VEGF treatment can give information about the visual outcomes in type 1 CNV.
Corrosivity relationship for management of buried pipelines: A case study of Rivers state, Nigeria
Authors: Amadi Azubuike , Ajienka Joseph , Akaranta Onyewuchi , Elijah Kehinde , Okafor Paul , Oluigbo Chiedozie 
Published: September 2022

Abstract
Control and management of corrosion have always been the concern of oil and gas asset management teams due to the challenging outcomes of failed facilities in service due to corrosion. Corrosion has an impact on human safety, environmental safety, and productivity; thus, it is important to know how corrosive an environment is in order to make the best investment decisions for facilities that are prone to corrosion. There are various ways of identifying environmental corrosivity, but there is no distinct map or relation with combined soil pH and resistivity impact unique to an environment that suggests the corrosion severity of such an environment, which could be due to the complexities of variables involved in defining the extent of corrosivity. This research aims to create a corrosion map using the MATLAB computing environment for Rivers State, a mega oil-producing state in the Niger Delta, based on soil resistivity and pH across different parts of the state with ongoing oil and gas activities for the purpose of a quick look decision-making guide. To determine corrosivity, such a map should only need to identify the soil resistivity and pH of a certain site. The pilot test conducted using 40-point soil pH and resistivity data suggested that it is feasible to develop a unique corrosivity map for a region since the result showed an R-square value of 70.03%. However, possible constraints of the mapping process were discussed, as well as suggestions for a wider survey and improvement.
Physicochemical and microbiological characteristics of Ras El-Ain basin, Tyr, Lebanon
Authors: Khatib Milad , Daoud Mohamad , Arairo Wahib , Saba Marianne , Mortada Hussein 
Published: September 2022

Abstract
Lebanon's natural water resources are facing serious problems related to quality and quantity. One of these issues is its deteriorating properties that is related to unregulated resource planning and rising demand. Water resources are used in many different applications such as residential, industrial, and irrigation. However, due to the over-exploitation, random use of surface water resources such as rivers, lakes, natural ponds the country is facing pressure related to the water demand and accessibility. This study focused on the Ras El-Ain area located in the South of Lebanon.. The Lebanese state dedicated it, along with other reservoirs, to supply potable water for Tyr and the surrounding villages. Today, these basins' water quality has deteriorated significantly because of unrestricted liquid and soil waste dumping. As a result, contaminants developed in these ponds. Aside from laboratory testing for water quality, contamination can be seen through direct observations, odors, watercolor, and patterns. The purpose of this study was to assess the level of pollution in the Ras El-Ain reservoirsThese natural pond have been progressively subjected to a variety of quality degradation characteristics. This includes the basic physiochemical characterization. As a result, the physicochemical and microbiological water characteristics of five selected samples from each pond were tested. These tests were performed following the European Standard Methods and World Health Organization guidelines (WHO). The effect of pollutant disposal in the Ras El-Ain was studied using multivariate approaches. The obtained results were then used to evaluate the extent of pollution in the several ponds.
Ecological network analysis of the carbon metabolism system in mountainous cities based on land-carbon nexus: A case study in the main urban area of Chongqing, China
Authors: Xiang Shujiang , Wang Ying , Deng Hua , Yang Chunmei , Wang Zifang , Gao Ming 
Published: September 2022

Abstract
Land use/cover change (LUCC) under rapid urbanization has led to a sharp increase in urban carbon emissions, an imbalance in carbon budgets, and climate warming. Therefore, the development of urban carbon metabolism research has become key to mitigating global warming and achieving China’s “Dual Carbon” targets. Taking the main urban area of Chongqing, a typical mountainous city in China, as an example, this study accounted for the carbon release and carbon absorption in the main urban area of Chongqing, constructed an urban carbon flow model based on the land-carbon nexus, and finally evaluated the urban carbon metabolic system from 2000 to 2020 by using the ecological network analysis method. The results show that: 1) During the study period, the carbon release of the main urban area of Chongqing was 31.43 times, 31.53 times, 49.43 times, 51.99 times, and 51.58 times that of the carbon absorption in 2000, 2005, 2010, 2015, and 2020, respectively. The main urban area of Chongqing is dominated by a “carbon source” effect, and the carbon budget imbalance has increased. 2) The net carbon flow in the main urban area of Chongqing has been negative in the past 20 years, showing a fluctuating downward trend. The negative carbon flow mainly comes from the conversion of cultivated land to construction land, and the positive carbon flow mainly comes from the conversion of construction land to cultivated land and woodland. 3) From the flow analysis, it can be seen that the H-index of the main urban area of Chongqing was 0.287, 0.189, 0.094, and 0.330, in respective chronologically ordered 5-year intervals, during the 20-year study period, showing a “V-shaped” change trend. From the perspective of structure analysis, it is clear that the carbon flow contribution level of each component is ranked as follows: cultivated land ＞construction land ＞ woodland ＞ water ＞ grassland ＞unused land. The utility analysis shows that the K-index of the main urban area of Chongqing was1.40, 0.80, 0.57, and 1.40, in respective 5-year intervals, during the study period, showing a “U-shaped” change trend. From the function relationship analysis, it can be seen that the ecological relationship of carbon metabolism in the main urban area of Chongqing is dominated by exploitation and control relationships, which mainly exist in the ecological relationship between construction land and cultivated land, and the spatial distribution is concentrated in the central and western areas of the main urban area of Chongqing. Our research results can provide a reference for Chongqing’s green and low-carbon sustainable development as a means toward the realization of the “Dual Carbon” targets, and provide a reference for other similar mountainous cities in western China.
Acute disseminated encephalomyelitis following inactivated COVID-19 vaccine: A case report
Authors: Sazgarnejad Saharnaz , Haghdoost Bahar , Molaei Mohammad Mahdi , Kordipour Vida , Amirifard Hamed 
Published: September 2022

Abstract
Background
Neurological involvement including CNS demyelination syndromes following SARS-CoV-2 infection have been reported as extra-pulmonary involvement in patients with COVID-19. Besides, immune-mediated central nervous system involvement is a rare phenomenon that is considered to be one of the most important and serious complications of vaccines as well. While regarding the recent pandemic and worldwide use of the COVID-19 vaccines investigating serious life-threatening side effects is worth considering.
Case presentation:
This article reported a young male Iranian patient without any past medical history and neurological problems who presented acute disorientation due to acute central nervous system demyelination approximately one month after receiving the first dosage of Sinopharm BIBP COVID-19 vaccine. Based on extended clinical investigations the patient had undergone the treatment with the highly probable diagnosis of acute disseminated encephalomyelitis syndrome.
Conclusion
In this article clinical presentation, diagnosis, and treatment of the patient with the diagnosis of ADEM following COVID-19 vaccine administration have been discussed. It seems for timely diagnosis and access to a safer state in our global immunization, reporting and evaluating the diagnosis approach and challenges in treatment and patient recovery regarding rare and adverse effects is worth considering.
Is there a Subnational Resource Curse? Evidence from Households in the Niger Delta Region of Nigeria
Authors: Animashaun Jubril , Emediegwu Lotanna 
Published: September 2022

Abstract
The local effect of extractive industries on households’ living standards is viewed in this study as a signal of non-homothetic preferences for education. Hydrocarbonbased industries are intensive in capital and high-skilled labor; our theory predicts that further development could increase investment in education due to local employment opportunities. However, investment in education can generate surplus skilled labor. Under imperfect markets, these constitute dynamic social costs with weak backward integration and ambiguous implications on welfare. Using annual household data from the Niger Delta between 2010 to 2016, we employ a geographic difference-in-difference estimation that exploits spatial and temporal variation in oil production and locations. We find that costs of living are higher by proximity to oil fields but find that the mechanism is via non-homothetic preferences for education. We find inconclusive evidence on other welfare indicators; limited employment opportunities in non-oil sectors may explain the weak backward linkages and potential positive spillovers. JEL Codes: O13, O18, Q32, J24, I2, R20
Profifitability of Ichimoku-based trading rule in Vietnam stock market in the context of the COVID-19 outbreak
Authors: Che-Ngoc Ha , Do-Thi Nga , Nguyen-Trang Thao 
Published: September 2022

Abstract
Ichimoku Kinkohyo or Ichimoku Cloud Chart is one of the most popular technical indicators used by traders all over the world. However, its profitability is heavily influenced by the market environment, to which it is applied. Furthermore, the COVID-19 outbreak may have an impact on the market environment as well as the performance of all technical indicators. This study is the first to look into the profitability of Ichimoku-based trading rules in the Vietnamese stock market in the context of the COVID-19 outbreak. More particularly, the COVID-19 outbreak has a positive influence on the performance of this strategy when considering the entire market as well as a variety of industries including real estate industry, food and beverage industry, resource industry, and automotive and electronic components industry. Compared to the pre-pandemic period, the return on investment obtained per each transaction using the Ichimoku-based strategy increased by roughly 8-9% in the pandemic period. Compared to the Buy-and-hold method, the Ichimoku-based strategy could slightly increase Accumulated return while posing a lower risk. The findings indicate that the Ichimoku-based strategy is applicable to the Vietnam stock market, regardless of the adverse effects of the pandemic on the industries.
Accuracy and clinical application of transcutaneous carbon dioxide monitoring in patients with sepsis
Authors: 林 婉 , 刘 勤富 , 杨 晓军 
Published: September 2022

Abstract
BACKGROUND: Repeated procurement of a blood gas specimen in patients with sepsis is likely to increase the risk of infection and iatrogenic anemia. Non-invasive transcutaneous carbon dioxide pressure (PtcCO2) as a surrogate of invasive arterial carbon dioxide pressure (PaCO2)，which is increasingly suggested for its accuracy and sustainability in recent years. The objective of this study was to explore the accuracy and clinical application of PtcCO2 in patients with sepsis.
METHODS: After approval of the local ethics committee PtcCO2 and PaCO2 were determined in n = 65 ICU patients with sepsis and n = 32 ICU non-sepsis patients. Bland–Altman method was used for statistical analysis, p＜0.05 was considered statistically significant.
RESULTS: Statistical analysis revealed good correlation between PtcCO2 and PaCO2 in septic patients (r=0.591, P<0.0001) as well as in non-sepsis patients (r=0.642, P<0.0001). Bland–Altman analysis revealed a bias and precision of 3.4±8.7 mmHg for the septic patients and 2.2 ± 5.7 mmHg for the non-sepsis patients, both of them indicated good accuracy. During the first 6 hours of standardized treatment in septic shock patients, lactate clearance was linearly correlated with PtcCO2 difference (r=0.479, P=0.005<0.05), suggesting that early changes in PtcCO2 levels may be associated with tissue perfusion.
CONCLUSIONS: PtcCO2 was a good alternative to PaCO2 in septic patients, and early changes in PtcCO2 may indicate changes in lactate clearance.
A novel nanocomposite based zeolite for efficient remediation of Cd- contaminated industrial wastewater
Authors: Elkhatib Elsayed A. , Moharem Mohamed L. , Saad Ahmed F. , Abdelhamed Safa 
Published: September 2022

Abstract

The nanostructured water treatment residuals (nWTR) were obtained through ball milling of bulk water treatment residuals (WTR) and then coated with zeolite (Ze). The prepared nanocomposite (Ze-nWTR) was characterized before and after Cd adsorption using SEM-EDX, XRD and FTIR analyses. Cadmium adsorption study was conducted in batch system at various conditions of solution pH, coexist competing ions, sorbent dose, temperature and contact time. Langmuir and power function models well fitted to Cd adsorption equilibrium and kinetic data respectively. The maximum adsorption capacity (qmax) value of the nanocomposite (147.9 mgg-1) was 3 and 5.9 times higher than those of nWTR and Zeolite sorbents, respectively. Increasing temperature from 287K to 307K caused increasing in qmax value from 147.9 mgg-1 to 270 mgg-1. The pH of point of zero charge (pHzpc) for nanocomposite was 7.2. Thermodynamic Parameters of Cd adsorption by nanocomposite were calculated at different initial Cd concentration and pH values. The high value range of ΔH° (123292 − 18600 J mol− 1) for Cd adsorption on nanocomposite reflects different forces governing the adsorption reaction. Furthermore, FTIR, XRD, and EDX analysis confirmed that combination reactions (nonspecific/specific interaction) are responsible for Cd adsorption on the nanocomposite. The reusability study revealed that (Ze-nWTR) nanocomposite could be reused effectively for up to 6 consecutive cycles. The results from this study confirmed the nanocomposite excellent removal ability (98%) of Cd from industrial wastewater.
Risk prediction of gestational diabetes mellitus in women with polycystic ovary syndrome based on a nomogram model
Authors: Ouyang Peilin , Duan Siqi , You Yiping , Jia Xiaozhou , Yang Liqin 
Published: September 2022

Abstract
Women with polycystic ovary syndrome are prone to develop gestational diabetes mellitus, a disease which may have significant impact on the postpartum health of both mother and infant. We performed a retrospective cohort study to develop and test a model that could predict gestational diabetes mellitus in the first trimester in women with polycystic ovary syndrome. Our study included 434 pregnant women who were referred to the obstetrics department between December 2017 and March 2020 with a diagnosis of polycystic ovary syndrome. Of these women, 104 were diagnosed with gestational diabetes mellitus in the second trimester. Univariate analysis revealed that in the first trimester, Hemoglobin A1c (HbA1C), age, total cholesterol(TC), low-density lipoprotein cholesterol (LDL-C), SBP (systolic blood pressure), family history, body mass index (BMI), and testosterone were predictive factors of gestational diabetes mellitus (P < 0.05). Logistic regression revealed that TC, age, HbA1C, BMI and family history were independent risk factors for gestational diabetes mellitus. The area under the ROC curve of the gestational diabetes mellitus risk prediction model was 0.937 in this retrospective analysis, demonstrating a great discriminatory ability. The sensitivity and specificity of the prediction model were 0.833 and 0.923, respectively. The Hosmer–Lemeshow test also showed that the model was well calibrated.
Atomic-scale interlayer friction of gibbsite is lower than brucite due to interactions of hydroxyls
Authors: Okuda Hanaya , Kawai Kenji , Sakuma Hiroshi 
Published: September 2022

AbstractTo investigate the role of atomic-scale structure on the frictional properties of gibbsite, a dioctahedral-type aluminum hydroxide, we calculated the atomic-scale interlayer shear properties using the first-principles method based on density functional theory. We found that the presence of vacant sites within the octahedral sheet of gibbsite enables hydroxyls to move to more stable positions and reduce the repulsive force, leading to a lower atomic-scale shear stress of gibbsite compared with brucite, a trioctahedral-type magnesium hydroxide. We also estimated the macroscopic single-crystal friction coefficient of gibbsite with the assumption that only the atomic-scale interlayer friction controls macroscopic friction. The estimated single-crystal friction coefficient for gibbsite is 0.36(6), which is clearly lower than the experimentally obtained friction coefficient of the powdered gouge of gibbsite (0.74). This difference between the interlayer friction coefficient and gouge friction coefficient suggests the presence of additional mechanisms that affect the frictional strength, such as microstructures within a fault gouge.
Michael Acceptors as a Tool for Anticancer Drug Design
Authors: Ahn Byung-Zun , Sok Dai-Eun 
Published: September 2022

Abstract:
Interaction of antitumor drugs with cellular targets involves various types of chemical binding, of which covalent binding is one of important strategies in designing effective anticancer molecules. The anticancer compounds employing covalent binding, structurally diverse, belong to many chemical classes, including quinones, mustards, nitrosourea, alkylsulfonate, pyrrolo[l,4]benzodiazepines, and others. Most of these compounds contain, or acquire by cellular metabolism, electrophilic centers, and some are Michael acceptors in a broader sense.
Recent evidences suggest that antineoplastic alkylating compounds bind directly to various cellular nucleophiles, thus lacking in a selectivity. Meanwhile, Michael acceptors can be structurally modified, so that they can react selectively with target nucleophiles or they can be converted into a selective Michael acceptors during metabolism. Moreover, we often meet these Michael acceptors in biochemical process of cellular respiration or in metabolisms of some drugs or xenobiotics.
A group of representative natural cytotoxic compounds containing Michael acceptor are naphthoquinones such as menadione and shikonin analogues, cytotoxic quassinoids, sesquiterpenoid benzoquinones, and others. Mitomycin, meanwhile, is transformed by reductive activation into a conjugated dienone as a Michael acceptor.
In this review, chemistry, cytotoxicity and antitumor action of anticancer agents containing Michael acceptors will be discussed in the respect of structure-activity relationship. More in-depth review will be given of the naphthazarin analogues. Also, cytotoxic terpenes such as ar-turmerone analogues, quassinoids, and others will be reviewed.