bluuebunny/crossref_metadata_2025_split huggingface dataset:
The frontal and sagittal patterns of neuromuscular spine deformities depending on the nosological profile
Authors: - Egor Filatov , Sergeenko Olga , - Dmitry Savin , Ochirova Polina , Ryabykh Sergey 
Published: March 2022

Abstract
Study Design: A prospective single-center study. Level of Evidence IVPurpose: To reveal frontal and sagittal patterns of spinal deformity depends on neuromuscular nosology for surgery and outcomes planning.Methods: The evaluation criteria were: age, gender of patients, volume of blood loss, duration of hospital stay, measurement of the deformity curve, thoracic kyphosis and lumbar lordosis (Cobb angle), pelvic obliquity relative to the horizontal line, the percentage of the curve correction. The Cobb angle was measured preoperatively, prior to discharge from the hospital (up to 21 postoperative days) and one year after surgery.Results: The cohort of 71 patients with spinal deformities due to neuromuscular diseases included four groups: muscular dystrophy (MD), spinal muscular atrophy (SMA), Duchenne muscular dystrophy (DMD) and cerebral palsy (CP). The most characteristic deformity in the frontal plane was C-shaped thoracolumbar scoliosis with the pelvis rotation, rotation of the vertebrae increased according to the magnitude of scoliosis. Lumbar hyperlordosis were common for CP patients, whereas decreased thoracic kyphosis or even thoracic lordosis occurs more frequently in DMD patients. Moderate scoliosis correction was noted in all groups. There was no significant improvement in functional status according to FIM.Conclusion: The findings showed that rigid hyperlordosis the key problem of spinal deformities in neuromuscular patients. Scoliosis and pelvic obliquity can be well corrected in NMS by pedicle screw construction with standard maneuvers and pelvic screw fixation.
Choice of health providers and health seeking behavior among forest goer population in Myanmar: Findings from a cross-sectional household survey
Authors: Khaing Myat Noe Thiri , Zin Su Su , Thein Si Thu , Director Kemi Tesfazghi , Thet May Me 
Published: March 2022

Abstract
BackgroundIn Myanmar, malaria still poses a significant burden for vulnerable populations particularly forest goers even though impressive progress has been made over the past decade. Limited evidence existed related to forest goers’ health seeking behavior and factors that drive decision making for providers’ choice to support national malaria programs towards elimination. In response to that, this research is conducted to identify who they prefer and what are the factors associated with providers’ choice in malaria febrile illness and Rapid Diagnostic Testing (RDT).MethodsA cross-sectional study applying quantitative household survey was completed with 479 forest goer households in 20 malaria endemic townships across Myanmar. The study collected household data together with the types of providers that they consulted for recent and previous febrile episodes. To identify the factors associated with providers’ choices, univariate and multivariate multinomial logistic regressions were done using Stata version 14.1. Statistical significance was set as p= 0.05.ResultsA total of 307 individuals experienced fever within one month and 72.3% sought a care from providers. And a total of 509 forest goers reported that they had a previous febrile episodes and 62.6% received care from a provider. Furthermore, 56.2% said that they had RDT testing during these previous febrile illnesses. They consulted public facilities and public health staff, private facilities, private and semi-private providers, community health volunteers or workers in their residing village and those located outside their village but majority prefer those within their village. On multivariate analyses, second richest quintile (Public, RRR=12.9) (semi-private, RRR=17.9), (outside, RRR=8.4) and, access to 4 and above nearby providers (Public, RRR=30.3) (semi-private, RRR=1.5) (outside, RRR=0.5) were found to be significantly associated with provider choice for recent fever episode. Similar findings were also found for previous febrile illness and RDT testing among forest goers. ConclusionThe study highlighted that in forest goer households, they preferred nearby providers and the decision to choose providers seemed to be influenced by their access to number of nearby providers and socio-economic status when they sought care from a provider regardless of fever occurrence location. It is important that the national programs consider involving these nearby providers in elimination efforts.
Utilization of Long – Acting Contraceptive Methods and Associated Factor among Female Health Care Providers in South Wollo Zone Hospitals, North East, Ethiopia. A cross sectional multicenter study
Authors: Yimer Aragaw Hamza , Walelign Fasil , Damtie Yitayish , Seid Ahmed Muhye , Seid Mehdi Shumiye 
Published: March 2022

Abstract
Background: - Long-acting contraception method utilization was found low (22.7%) among female health care providers. However, as far as my literature search no study was done on long-acting contraception methods utilization among female health providers in the study area. These studies failed to include important variable like socio demography and individual factor which might affect the use of long-acting contraceptive methods female health providers and limited studies in Ethiopia. Objective: - To assessing utilization of long -acting contraceptive methods and associated factors among health care providers in south wollo zone public hospitals, Amhara region, Ethiopia 2021.Methods: -An Institutional-based cross- sectional was conducted among 354 female health care workers in south wollo zone hospitals, from March to April 22, 2021. The participants were selected using Systematic random sampling technique. Data were collected by using self-administered questionnaire. The data were entered Epi-data version 4.1 and export to SPSS versions 25 for analysis. Bivariable and multivariable logistic regression analysis were performed. The Adjusted odd Ratio (AOR) along with a 95% confidence interval (CI) was estimated to measure the association and level of significance was declared at a P- value of less than 0.05.Result: -The current utilization of long-acting contraceptive methods among female health care providers was found to be 33.6% [95%, CI 29-39)], discuss with partner [AOR= 2.277,95% CI, (1.026-5.055)], method shift/switched [AOR=4.302,95% CI, (2.285-8.102)], knowledge of respondent [AOR= 1.887,95% CI, (1.020-3.491)], ever birth [AOR=15.670,95% CI, (5.065-48.49)] were significant factors towards the utilization of long-acting contraceptive methods.Conclusion and recommendation: -The current utilization of long-acting contraceptive methods was found low. Discus with partner, methods shift/switching, ever birth and knowledge of respondents were identified as significant factor. Therefore, encouraging partner discussion targeted Information Education Communication Intervention should be intensified to improve long-acting contraceptive methods utilization.
MWCNT/CuO/Fe3O4/Polyaniline Nanocomposites with Remarkable Microwave Attenuation and Broad Frequency Band by Tuned Composition
Authors: Afzali Saeedeh-Sadat , Hekmatara Seyedeh Hoda , Seyed-Yazdi Jamileh 
Published: March 2022

Abstract
Novel quaternary MWCNT/CuO/Fe3O4/PANI nanocomposites were synthesized with three different weight ratios of CuO/Fe3O4/PANI to MWCNT (1:3), (1:4), and (1:5), in a way, all its components were synthesized separately and then combined with certain weight ratios. TEM image of CuO/Fe3O4/PANI proved that most of the nanoparticles were in a form of CuO/Fe3O4 hybrids with narrow size distribution which were uniformly dispersed in a polymer background. TEM and SEM of MWCNT/CuO/Fe3O4/PANI nanocomposite indicated that MWCNT was covered with a uniform thickness of CuO/Fe3O4/PANI. All three samples of nanocomposites exhibited excellent microwave attenuation performance via both aspects of reflection loss and absorption bandwidth. Minimum reflection losses were 45.7, 58.7 and 85.4, 87.4 dB for MWCNT/CuO/Fe3O4/PANI nanocomposites (1:3), (1:4) and (1:5), respectively. Absorption bandwidths (RL ≤ -10 dB) were 6, 7.6 and 6 GHz, for MWCNT/CuO/Fe3O4/PANI nanocomposites (1:3), (1:4) and (1:5), respectively.
Primary melanoma of the bladder: case report and review of the literature
Authors: Dai Jindong , He Ben , Liu Zhi-Hong , Shen Peng-Fei , Shi Ming 
Published: March 2022

Abstract
Background: Primary melanoma of the urinary bladder is extremely rare and has been sporadically reported in case reports. Its incidence, diagnosis, treatment, and outcomes are still unclear. Case presentation: We report a case of 67 years-old female patient who presented with hematuria and was diagnosed with primary melanoma of the urinary bladder by transurethral resection of bladder tumor. Fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) revealed no lymph node nor distant metastasis. After multidisciplinary discussion, the patient received laparoscopic radical resection of bladder tumor. There was no tumor recurrence or distant metastasis after 10 months of follow-up. Conclusion: Primary melanoma of the urinary bladder is easily confused with urothelium carcinoma in morphology. The immunohistochemical is crucial in diagnosis. Because of lack of in-depth understanding of primary melanoma of bladder, "Gold standard" treatment has not been set. We would like to provide some rare information about primary melanoma of the urinary bladder and discuss the best strategy for the treatment of rare disease.
DNA barcodes revealed population dependent cryptic diversity and various sympatry of Korean leptonetid spider (Araneae: Leptonetidae)
Authors: Oh Jong-Hwa , Kim Sora , Lee Seunghwan 
Published: March 2022

Abstract
Leptonetidae are tiny and rarely encountered spiders, mainly inhabiting moist environments such as caves, leaf litter, and rock piles. Because they are microhabitat specialists, most species are known to have short range endemism, rarely occurring in sympatry. Due to their small size, relatively simple features of habitus and structure of reproductive organs made it challenging on sufficient identification. Not only leptonetids, but also identification in other spiders having sexual dimorphism, polymorphism, and lack of diagnosable keys in juvenile made it even more time consuming. To overcome these obstacles, DNA barcoding has been used as an effective tool for species identification. Herein, we conducted a test of DNA barcoding with Korean Leptonetidae based on 422 specimens representing 76 morphospecies. A threshold of 4.2% genetic divergence was estimated to differentiate the morphological species efficiently. The species assignments tested by five species delimitation methods (ABGD, ASAP, GMYC, PTP, and bPTP) were consistent with morphological identifications for 49 species (64.5%), indicating many cases of cryptic diversity. Further, sympatry in leptonetids was revealed to be common in South Korea, especially in epigean species. Our results showed sympatries no matter within family, congeners, and interclade potentially occurring throughout the entire region of the Korea.
Progressive right ventricular dysfunction and exercise impairment in patients with heart failure and diabetes mellitus: insights from the T.O.S.CA. Registry
Authors: Salzano Andrea , D’Assante Roberta , Iacoviello Massimo , Triggiani Vincenzo , Rengo Giuseppe , Cacciatore Francesco , Maiello Ciro , Limongelli Giuseppe , Masarone Daniele , Sciacqua Angela , Filardi Pasquale Perrone , Mancini Antonio , Volterrani Maurizio , Vriz Olga , Castello Roberto , Passantino Andrea , Campo Michela , Modesti Pietro A , De Giorgi Alfredo , Arcopinto Michele , Gargiulo Paola , Perticone Maria , Colao Annamaria , Milano Salvatore , Garavaglia Agnese , Napoli Raffaele , Suzuki Toru , Bossone Eduardo , Marra Alberto M , Cittadini Antonio 
Published: March 2022

Abstract
Background
Findings from the T.O.S.CA. Registry recently reported that patients with concomitant chronic heart failure (CHF) and impairment of insulin axis (either insulin resistance- IR or diabetes mellitus- T2D) display increased morbidity and mortality. However, little information is available on the relative impact of IR and T2D on cardiac structure and function, cardiopulmonary performance, and their longitudinal changes in CHF.
Methods
Patients enrolled in the T.O.S.CA. Registry performed echocardiography and cardiopulmonary exercise test at baseline and at a patient-average follow-up of 36 months. Patients were divided into three groups based on the degree of insulin impairment: euglycemic without IR (EU), euglycemic with IR (IR), and T2D.
Results
Compared with EU and IR, T2D was associated with increased filling pressures ( E/e’ ratio : 15.9 ± 8.9, 12.0 ± 6.5, and 14.5 ± 8.1 respectively, p < 0.01) and worse right ventricular(RV)-arterial uncoupling (RVAUC) (TAPSE/PASP ratio 0.52 ± 0.2, 0.6 ± 0.3, and 0.6 ± 0.3 in T2D, EU and IR, respectively, p < 0.05). Likewise, impairment in peak oxygen consumption (peak VO2) in TD2 vs EU and IR patients was recorded (respectively, 15.8 ± 3.8 mL/Kg/min, 18.4 ± 4.3 mL/Kg/min and 16.5 ± 4.3 mL/Kg/min, p < 0.003). Longitudinal data demonstrated higher deterioration of RVAUC, RV dimension, and peak VO2 in the T2D group (+ 13% increase in RV dimension, -21% decline in TAPSE/PAPS ratio and − 20% decrease in peak VO2).
Conclusion
The higher risk of death and CV hospitalizations exhibited by HF-T2D patients in the T.O.S.CA. Registry is associated with progressive RV ventricular dysfunction and exercise impairment when compared to euglycemic CHF patients, supporting the pivotal importance of hyperglycaemia and right chambers in HF prognosis.
Trial registration
ClinicalTrials.gov identifier: NCT023358017
A Perfect Model Study on the Reliability of the Added Small-Scale Information in Regional Climate Change Projections
Authors: Lenderink Geert , de Vries Hylke , Meijgaard Erik van , Wiel Karin van der , Selten Frank 
Published: March 2022

Abstract
The issue of the added value (AV) of high resolution regional climate models is complex and still strongly debated. Here, we approach AV in a perfect model framework within a 16-member single model initial condition large ensemble with the regional climate model RACMO2 embedded in the global climate model EC-Earth2.3. In addition, we also used an ensemble produced by a pseudo global warming (PGW) approach. Results for winter temperature and precipitation are investigated from two different perspectives: i) a signal-to-noise perspective analysing the systematic response to changing emission forcings versus internal variability, and ii) a prediction perspective aimed at predicting a 30-year future climate state. Systematic changes in winter temperature and precipitation contain fine-scale response patterns, but in particular for precipitation these patterns are small compared to internal variability and single members of the ensemble therefore only provide limited information on these systematic patterns. However, they can be estimated more reliably from PGW members because of the stronger constraints on internal variability. From the prediction perspective, we analysed AV of fine-scale information by comparing three set of prediction pairs. This analysis shows that there is added value in the fine-scale information for temperature, yet for precipitation adding fine-scale changes generally deteriorates the predictions. Using only the large-scale change (without fine scales) from a single ensemble member as a delta change on top of the present-day climate state, already provides a robust estimate of the future climate state and therefore can be used as a simple benchmark to measure added value.
Apportionment of Average Annual Flood Loss between Homeowner and Insurer
Authors: Rahim Md Adilur , Friedland Carol , Mostafiz Rubayet Bin , Rohli Robert , Bushra Nazla 
Published: March 2022

Abstract
Accurate economic loss assessment for natural hazards is vital for planning, mitigation, and actuarial purposes. The widespread and costly nature of flood, with the economically disadvantaged disproportionately victimized, makes flood loss assessment particularly important. A shortcoming in existing flood loss models is absence of partitioning the building economic value of average annual loss (AAL) into that borne by the homeowner and by flood insurance. This research models the flood AAL incurred by the homeowner vs. by the insurer, focusing on the National Flood Insurance Program in the U.S., using Monte Carlo simulation at the individual homeowner scale. A hypothetical case study reveals that a $1500 or $3000 deductible is associated with a homeowner portion of 13 or 24 percent of the AAL, respectively, with homeowner proportion relatively insensitive to the combinations of coverage, AAL, and increase in first-floor height evaluated. In general, results inform the proactive decision-making process that allows homeowners to self-assess their degree of preparation and vulnerability to the devastating economic impacts of flood. By upscaling the results to the community level, results also assist planners and leaders in understanding the degree of community-level flood vulnerability and resilience, thereby affording possibilities for improved preparation.
Preclinical effects of melatonin on the development of Ehrlich's tumor: a biochemical, cognitive, and molecular approach
Authors: Lopes Ivan Pereira , Bagatela Bianca Souza , Lopes Andrey Pereira , Silveira Elaine Ferreira , Petri Giuliana , Santos José Francisco Ramos , Perez Matheus Moreira , Veiga Glaucia Luciano , Alves Beatriz , Perazzo Fabio Ferreira , Feder David , Fonseca Fernando Luiz Affonso 
Published: March 2022

Abstract
It has already been shown that the melatonin is an antitumoral molecule that affects malignant cells via some mechanisms. The benefits played by this hormone on cancer apparently is due to its antioxidant effects. This study aimed to evaluate the preclinical effects of melatonin on the Ehrlich ascites tumor. Twenty Balb/ c male mice with Ehrlich tumor were treated with different melatonin doses. Their inflammatory and oxidative stress were accessed by gene expression. Hepatotoxicity and hematological parameters were also evaluated through biochemical analyzes. Animal welfare was analyzed weekly from the categories guided by the NC3Rs. All groups treated with melatonin showed decreased SOD expression compared to the control; TNF-α expression, however, was higher in M-3 group. In the hepatic and hematological analyzes, the use of melatonin did not present significant changes in its results, that is, no hepatotoxicity could be identified. Melatonin played an important role in maintaining the parameters evaluated when referring to the well-being of the treated groups when compared to the control group. In the cognitive evaluation, the group that was treated with melatonin at the dosage of 3mg, presented better performance when compared to the others.
Pseudolaric acid B induces apoptosis in MG-63 human osteosarcoma cells through Bcl-2 degradation and caspase-dependent pathway
Authors: Zhu Jin 
Published: March 2022

Abstract
Pseudolaric acid B (PAB) is the primary bioactive compound isolated from traditional Chinese herb Tu-Jin-Pi, and exerts anti-tumor effects in various types of human cancer cells. However, so far, there has been no any study concerning the effect of PAB on human osteosarcoma (OS) cells. In the present study, we for the first time reported the anti-tumor effects of PAB on MG-63 OS cells. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay and clone formation assay showed that PAB significantly inhibited MG-63 cell proliferation in a dose- and time-dependent manner. The typical morphology changes and results of Annexin V-FITC/PI staining indicated that PAB induced apoptosis occurred in MG-63 cells. Furthermore, we also proved that PAB had the ability to suppress the migration and invasion of MG-63 cells. The western blotting data suggested that PAB induced apoptosis may be attributable to the increased Bax and Bcl-2 degradation through caspase-3 dependent singaling pathways. In conclusion, these findings revealed that PAB possessed significant antitumor effects on MG-63 cells and might serve as a novel therapeutic agent for the treatment of human OS.
Evolutionary Analysis of the Steroidogenic Acute Regulatory Protein-Related Lipid Transfer Domain and Its Response to Salt Stress In Vitis Vinifera
Authors: Lu Shixiong , He Honghong , Gou Huiming , Zhou Qi , Cao Xuejing , Wang Ping , Liang Guoping , Ma Zonghuan , Chen Baihong , Mao Juan 
Published: March 2022

Abstract
This study aimed to enhance the understanding of the steroidogenic acute regulatory protein-related lipid transfer (START) domain in Vitis vinifera. A total of 23 members of the VvSTARD gene family were found, which could be divided into five groups. The analyses of the gene codon preference, selective pressure, and tandem replication events of the VvSTARD, AtSTARD, and OsSTARD genomes indicated that tandem replication events occured in grapes, Arabidopsis, and rice genomes. Eight lipid transporter proteins were found in the tertiary structure of the STARD gene family in grapes. The analysis of the expression profiles of the three species microarrays showed that the expression sites of the STARD gene and the response to abiotic stress in the same subgroup had similar characteristics. In addition, quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze the expression of the STARD gene family in grape leaves in response to different hormones and abiotic stresses, and the obtained results were the same as those predicted by the cis-elements and the expression profiles. Furthermore, 35S:STARD5:EGFP was successfully constructed to verify the subcellular prediction results, and the results showed that STARD5 was located in the nucleus. Through the identification of salt tolerance of transgenic tomato, STARD5 was found to regulate the salt stress of plants. Collectively, these data indicated that the VvSTARD gene family plays an important role in response to salt stress.