bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiographic Cutoff Values for Predicting Lateral Bony Impingement in Progressive Collapsing Foot Deformity
Authors: Kim Jaeyoung , Rajan Lavan , Fuller Robert , Sofka Carolyn , Cororaton Agnes , Demetracopoulos Constantine , Ellis Scott , Deland Jonathan 
Published: June 2022

Background: Lateral bony impingement is a major cause of lateral foot pain in progressive collapsing foot deformity (PCFD). Weightbearing computed tomography (WBCT) provides better sensitivity than standard radiographs for detecting impingement. However, many orthopaedic centers have not yet acquired WBCT imaging. This study aimed to (1) investigate the correlation of common radiographic parameters measured on standard weightbearing radiographs with talocalcaneal and calcaneofibular distance assessed with WBCT and (2) establish radiographic cutoff values to detect bony impingement as identified on WBCT. Methods: Ninety-one patients treated for PCFD with standard preoperative radiographs and WBCT were identified. Patients with asymmetric ankle arthritis (talar tilt >2 degrees) were excluded. The talocalcaneal distance at the sinus tarsi and calcaneofibular distance were measured in multiplanar reconstructed WBCT images. Impingement was defined as direct abutment between bones. The relationships between WBCT measurements and 4 common parameters (talonavicular coverage angle [TNC], talo–first metatarsal angle, calcaneal pitch, and hindfoot moment arm [HMA]) in standard radiographs were assessed with Pearson correlations. Receiver operating characteristic curve analysis evaluated the ability of radiographic cutoffs to detect sinus tarsi or calcaneofibular bony impingement, and the area under curve (AUC), sensitivity, specificity, negative and positive predictive value (PPV) were calculated. Results: Talocalcaneal distance narrowing at the sinus tarsi strongly correlated with TNC ( r = 0.64, P < .001), and the calcaneofibular distance narrowing correlated with the HMA moderately yet best among the parameters ( r = 0.55, P < .001). TNC (AUC = 0.837, 95% CI 0.745-0.906) and HMA (AUC=0.959, 95% CI 0.895-0.989) provided the best predictive ability for sinus tarsi and calcaneofibular bony impingement, respectively. A TNC threshold of 41.2 degrees had a 100% PPV for predicting sinus tarsi impingement, whereas an HMA threshold of 38.1 mm had a 100% PPV for calcaneofibular impingement. Conclusion: This study provides evidence that TNC and HMA measurements made on standing radiographs could be used to indicate potential lateral bony impingement in PCFD. Narrowing of talocalcaneal distance best correlated with abduction deformity of the foot, and the narrowing of calcaneofibular distance was best correlated with valgus hindfoot deformity. Level of Evidence: Level III, case control study.
Perspectives toward biosimilars among oncologists: A Malaysian survey
Authors: Chong Soon Cien , Rajah Retha , Chow Poh Lee , Tan Hsio Ching , Chong Chin Man , Khor Kar Yee , Lee Wan Ping , Tan Wan Ying 
Published: June 2022

Introduction Biosimilars confer significant cost-saving advantages and expand patients’ access to biologic therapies in cancer care. In line with the increasing availability of antineoplastic biosimilars, it is pertinent to understand the oncologists’ view on the adoption of biosimilars in their clinical practice. The study aimed to assess (i) the prevalence of biosimilar use, (ii) perception towards biosimilars, (iii) factors influencing the use of biosimilars and (iv) knowledge about biosimilars among Malaysian oncologists. Methods A cross-sectional survey was conducted among clinical oncologists and medical oncologists in Malaysia between January 2020 and February 2021 using a structured 31-item questionnaire. Results Among the 121 oncologists registered in the country, 36 responded (response rate  =  30%). A total of 64% of the respondents prescribed biosimilars either often or always. Most oncologists (72%) agreed or strongly agreed that switching will not have a significant effect on the treatment benefit, with lower percentages saying that they agreed or strongly agreed that it will not lead to the emergence of additional adverse effects (56%) or harmful immunogenicity (64%). Patients’ preferences (40%) and the non-availability of biosimilars in hospitals (34%) are the major barriers cited to the prescribing of biosimilars. Cost differences and robust pharmacovigilance activities are the two most important factors that would influence the prescribing of biosimilars. The mean score of knowledge in biosimilar among respondents was 3.81 (± 0.86) out of a maximum possible score of 6. Conclusions The identified gap in prescribing and the use of biosimilars among Malaysian oncologists warrant educational intervention and robust pharmacovigilance activities to facilitate the prescribing of biosimilars and ultimately increase the accessibility to biologics in cancer treatment.
Paraphilic Interests Versus Behaviors: Factors that Distinguish Individuals Who Act on Paraphilic Interests From Individuals Who Refrain
Authors: Molen Lauryn Vander , Ronis Scott T. , Benoit Aryn A. 
Published: June 2022

Little is known about distinct factors linked with acting on paraphilic interests or refraining from engaging in paraphilic behaviors. Participants from Canada and the United States ( N = 744), aged 19–42 years ( M = 29.2; SD = 3.18), were recruited through Amazon’s Mechanical Turk. Participants completed questionnaires about their paraphilic interests and behaviors, as well as potential key factors linked to behavioral engagement (i.e., perceptions of consent, sexual excitation/inhibition, impulsivity, moral disengagement, empathy). Results indicated that higher moral disengagement and impulsivity, lower sexual control (i.e., high sexual excitation, low sexual inhibition), and maladaptive understandings of consent were best able to differentiate individuals who reported highly stigmatized (e.g., hebephilia, pedophilia, coprophilia) or Bondage and Dicipline, Dominance and Submission, Sadism and Masochism(BDSM)/Fetish paraphilic interests and engagement in the paraphilic behaviours associated with these interests relative to individuals who did not report such paraphilic interests or behaviors. Moreover, higher moral disengagement, impulsivity, and maladaptive perceptions of consent were best able to differentiate non-consensual paraphilic interests and behaviours (e.g., voyeurism, exhibitionism) compared to individuals who did not report these paraphilic interests or behaviours. These results provide future directions for the exploration of mechanisms that may contribute to engagement in paraphilic behaviors and may be targets for intervention aimed at preventing engagement in potentially harmful paraphilias.
Subtenon triamcinolone injection to treat serous choroidal detachment after glaucoma surgery: A case series
Authors: Nilforushan Naveed , Abolfathzadeh Navid , Najafzadeh Farhad , Samimifar Deniz 
Published: June 2022

Purpose To report the effect of subtenon triamcinolone acetonide (TA) injection in the treatment of serous choroidal detachment (SCD) after glaucoma surgery. Methods In this prospective case series, patients with persistent, non-resolving, or progressive SCD after glaucoma surgery were enrolled. For those with non-resolving or progressive SCD despite of using systemic corticosteroids, topical atropine and topical steroids, one milliliter of TA (40mg/mL) was injected inferotemporally into the posterior subtenon space. Results Sixteen consecutive patients with a mean ± SD age of 70.12 ± 11.12 years were included in this study. After injection of subtenon TA, SCD was completely resolved after 1 to 4 weeks, with deepening of the anterior chamber in all cases. All cases were followed for at least 6 months after the injection with no signs of recurrence. Conclusion Subtenon injection of TA is a safe and effective modality of treatment for resolving a persistent or progressive SCD after glaucoma surgeries.
Occupational Injuries and Associated Factors Among Municipal Solid Waste Collectors in Harar Town, Eastern Ethiopia: A Cross Sectional Study
Authors: Temesgen Liku Muche , Mengistu Dechasa Adare , Mulat Salie , Mulatu Gutema , Tolera Sina Temesgen , Berhanu Ashenafi , Baraki Negga , Gobena Tesfaye 
Published: June 2022

Background: Municipal solid waste collection is one of the most dangerous jobs in the world since it exposes the workers involved to occupational hazards and predisposes them to certain occupation-related morbidities. Occupational injuries among municipal solid waste collectors have not been adequately addressed or reported in developing countries, including Ethiopia. Therefore, this study aimed to determine the prevalence of occupational injuries and associated factors among municipal solid waste collectors in Harar Town, Ethiopia. Methods: A cross-sectional study was conducted in Harar town, Eastern Ethiopia from May 25, 2021 to June 25, 2021. Three hundred eighty-nine (389) municipal solid waste collectors were selected using a simple random sampling method. A self-administered structured questionnaire and an observational checklist were used to collect the data. The collected data was analyzed using SPSS version 20. Bivariate and multivariable logistic regression were used to determine the association between independent variables and the outcome variable. A P-value of <.05 was considered as a cut-off point for statistical significance. Results: The current study found that about 60.4% of municipal solid waste collectors were exposed to occupational injuries. Furthermore, the study found a statistically significant association between the prevalence of occupational injuries and having a primary education [AOR = 0.10, 95% CI (0.03-0.38)], a secondary education [AOR = 0.04, 95% CI (0.03-0.45)], work experience [AOR = 5.975, (95% CI (2.01-17.75)], the use of personal protective equipment [AOR = 0.09, (95% CI: 0.02-0.46)], and training [AOR = 0.10, 95% CI (0.03-0.30)]. Conclusions: The current study found that more than three-fifth of municipal solid waste collectors were exposed to occupational injury. Furthermore, the current study found that there was an statistical relationship between the prevalence of occupational injuries and having a primary education, a secondary education, work experience, the use of personal protective equipment, and training. Before and after hiring solid waste collectors, employers should provide personal protective equipment and tailored training on safety measures.
Effectiveness of Baduanjin Exercise on Quality of Life and Psychological Health in Postoperative Patients With Breast Cancer: A Systematic Review and Meta-analysis
Authors: Ye Xin-Xin , Ren Zi-Yang , Vafaei Somayeh , Zhang Jun-Meng , Song Yuan , Wang Yang-Xin , Song Pei-Ge 
Published: June 2022

Background: Baduanjin exercise is a traditional Chinese Qigong exercise. This study aimed to investigate the effects of Baduanjin exercise on the quality of life and psychological status of postoperative patients with breast cancer. Methods: A systematic review and meta-analysis were conducted. Eight databases were searched from inception to December 15, 2021, restricting the language to English and Chinese. RevMan5.3 software was employed for data analysis. This study was registered in PROSPERO, number CRD 42020222132. Results: A total of 7 randomized controlled trials (RCTs) with 450 postoperative breast cancer patients with or without Baduanjin exercise were collected. Compared with the group without Baduanjin, those who practiced Baduanjin showed significant improvement in quality of life (WMD = 5.70, 95% CI 3.11-8.29, P < .0001). Subgroup analysis showed significant improvement in physical (WMD = 1.83, 95% CI 1.13-2.53, P < .00001) and functional well-being (WMD = 1.58, 95% CI 0.77-2.39, P = .0001), which were measured by the functional assessment of cancer therapy-breast (FACT-B). Subgroup analysis also showed that role-physical (WMD = 11.49, 95% CI 8.86-14.13, P < .00001) and vitality (WMD = 8.58, 95% CI 5.60-11.56, P < .00001) were significantly increased, as measured by a 36-item Short Form survey (SF-36). In terms of psychological health, Baduanjin exercise reduced patients’ anxiety (WMD = −8.02, 95% CI −9.27 to −6.78, P < .00001) and depression (WMD = −4.45, 95% CI −5.62 to −3.28, P < .00001). Conclusions: Baduanjin is an effective exercise, which can significantly improve the quality of life and psychological health of breast cancer patients after operation.
US Black cisgender women and pre-exposure prophylaxis for human immunodeficiency virus prevention: A scoping review
Authors: Conley Cherie , Johnson Ragan , Bond Keosha , Brem Sullivan , Salas Jasmine , Randolph Schenita 
Published: June 2022

Background: Black cisgender women in the United States experience a disproportionate burden of human immunodeficiency virus acquisition. Pre-exposure prophylaxis is an effective oral daily medication that reduces the risk of human immunodeficiency virus through sex by 99% when taken as prescribed. However, less than 2% of eligible Black cisgender women take pre-exposure prophylaxis. The purpose of this scoping review was to describe the types of research studies done in this area, gaps in knowledge, and potential areas of research needed to increase pre-exposure prophylaxis use among Black cisgender women in the United States. Methods: We conducted our search in MEDLINE (PubMed), Embase (Elsevier), CINAHL (EBSCOhost), PsycINFO (EBSCOhost), and Scopus (Elsevier) using a combination of keywords and database-specific subject headings for the following concepts: pre-exposure prophylaxis, African American/Black or minority, and women. We used the Joanna Briggs Institute’s Reviewers’ Manual process for Scoping Reviews and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews to ensure comprehensive and standardized reporting of each part of the review. Results: Fifty-nine studies were included in the final review. Results of the study were classified according to the three phases of the Human Immunodeficiency Virus Prevention Cascade—demand side, supply side, and adherence and retention. The majority of studies ( n = 24, 41%) were cross-sectional quantitative surveys and 43 (34%) focused on the demand-side phase of the Human Immunodeficiency Virus Prevention Cascade. Fifty-eight percent of studies either assessed women’s pre-exposure prophylaxis knowledge, attitudes, and intentions to use, or assessed perceived barriers and facilitators. Seven studies (12%) tested pre-exposure prophylaxis uptake and adherence among Black cisgender women. Conclusion: This review found multiple missed opportunities to increase women’s demand for pre-exposure prophylaxis and health care provider screening and referral for pre-exposure prophylaxis. Additional studies are needed to effectively assess pre-exposure prophylaxis uptake and adherence among Black cisgender women.
Real-world evidence to assess the effectiveness of platelet-rich plasma in the treatment of knee degenerative pathology: a prospective observational study
Authors: Sánchez Mikel , Jorquera Cristina , de Dicastillo Leonor López , Fiz Nicolás , Knörr Jorge , Beitia Maider , Aizpurua Beatriz , Azofra Juan , Delgado Diego 
Published: June 2022

Objective: The present work aims to analyse the effectiveness of platelet-rich plasma (PRP) in degenerative knee pathology based on real-world data and to evaluate possible factors influencing the response to treatment. Methods: In total, 531 cases were analysed collecting data on gender, age, body mass index, pathology location, severity, number of cycles and route of administration. Clinical outcome was evaluated at 6 and 15 months after treatment, using the Knee injury and Osteoarthritis Outcome Score (KOOS) and obtaining percentages of Minimal Clinically Important Improvement (MCII). Blood and PRP samples were randomly tested as a quality control measure to ensure the correct properties. Comparative statistical tests and multivariate regression were performed for the analysis of the variables. Results: The PRP applied had a platelet concentration factor of 1.67, with no leukocytes or erythrocytes. The percentage of patients with MCII at 6 and 15 months after PRP application was 59.32% and 70.62%, respectively. Patients with MCII were younger ( p = 0.0246) and with lower body mass index ( p = 0.0450). The treatment had a better response in mild/moderate cases than in severe cases ( p = 0.0002). Intraosseous PRP application in severe cases improved the effect of intraarticular PRP ( p = 0.0358). The application of a second cycle of PRP only improved the response in patients without MCII at 6 months ( p = 0.0029), especially in mild/moderate cases ( p = 0.0357). Conclusion: The applications of PRP in degenerative knee pathologies is an effective treatment, but this effectiveness nonetheless depends on several variables. Real-world data can complement that from clinical trials to provide valuable information.
Impact of Productive Activities on Forest Cover Change in the Calakmul Biosphere Reserve Region: Evidence and Research Gaps
Authors: Špirić Jovanka , Vallejo Mariana , Ramírez M. Isabel 
Published: June 2022

Background and Research Aims Human activities seeking to satisfy various needs have resulted in deforestation and other forest cover change processes. The Natural Protected Areas are among the most efficient instruments to contain forest loss. The compensation from conservation is not sufficient to compete with land uses with higher economic rent, such as timber extraction and food production. This study summarizes the evidence and identifies research gaps on forest processes caused by productive activities in Mexico’s Calakmul Biosphere Reserve. Methods We systematically reviewed the scientific literature investigating forest processes caused by the productive activities in the Calakmul, including the transition zone. We calculated the frequencies of codes on forest processes and productive activities in the entire sample (53), evaluated each code’s significance in the qualitative synthesis and interpretation, and summarized the measurements of forest processes considering only the primary studies (46). Results Deforestation was the most commonly investigated process. Traditional agriculture initially caused deforestation, while livestock and conventional agriculture became more dominant recently with the agricultural intensification policies. Few articles investigated forest degradation experiencing a steady increase from fallow shortening and selective logging. Also, few studies identified forest recovery resulting from long fallows and core zone delimitation. No publications evaluated the forest cover impact of sustainable initiatives. Conclusion The tendency to quantify deforestation on a regional scale masks presence of other forest processes. The rural development programs in Calakmul did not include the environmental perspective, while participation in sustainable initiatives was low. The understanding of productive activities at the local level will allow differentiation of the long-term from temporary forest dynamic. Implications for Conservation To assure resilient and inclusive growth in Calakmul, the reduced-impact logging, sustainable agricultural intensification, improved fallows, and beekeeping should be supported with monetary resources that cover the transaction costs of unsustainable livestock breeding and industrial agriculture.
The Management and Outcome of Stroke Patients Admitted on Weekdays Compared to Weekends at the King Abdulaziz Medical City, Riyadh, Saudi Arabia
Authors: Khatri Ismail A. , Alhamdan Wejdan A. , Alsahli Afnan A. , Alshahwan Sarah I. , Almutairi Ghada M. , Alnamee Sadeem K. , Alsowailmi Ghada A. , Alotaibi Amal O. , Omair Aamir 
Published: June 2022

Background and Purpose Stroke is an unexpected medical emergency that can result in significant disability. The weekend effect suggests that individuals with acute medical problems are not treated the same way on weekends as they are on weekdays. There is no previous published study about weekend effect on stroke patients from Saudi Arabia. Methods This was an IRB approved, retrospective, cohort study. All stroke patients admitted between January 2017 and December 2018 were included. Ten standards of care were chosen to assess compliance with standardized care. Seven measures were chosen for acute management of stroke. Results A total of 731 patients were included, 68.5% were males; 493 (67%) were admitted during weekdays and 238 (33%) on weekends. There was no difference for age ( P = .32), gender ( P = .32), nationality ( P = .62), stroke subtype ( P = .27) and stroke severity ( P = .69) on weekday or weekend admission. In two-third patients, more than 70% of stroke orders were utilized, with no difference in thrombolysis rate ( P = .81). There was no difference in recurrent stroke ( P = .86), mortality or discharge disposition ( P = .34) between the patients. The patients admitted during weekdays had less complications (38 vs 46%; P = .04). Conclusions There was no difference in the quality of care provided to stroke patients admitted during weekdays or weekends. There was no difference in the use of acute intervention on weekends and weekdays. Patients had similar outcomes and discharge disposition whether admitted on weekdays or weekends, except that those admitted on weekends had a significantly greater overall number of complications.
Endovascular treatment of patients with acute ischemic stroke and tandem occlusion due to internal carotid artery dissection: A multicenter experience
Authors: Da Ros Valerio , Pusceddu Federica , Lattanzi Simona , Scaggiante Jacopo , Sallustio Fabrizio , Marrama Federico , Bandettini di Poggio Monica , Toscano Gianpaolo , Di Giuliano Francesca , Rolla-Bigliani Claudia , Ruggiero Maria , Haznedari Niccolo , Sgreccia Alessandro , Sanfilippo Giuseppina , Finocchi Cinzia , Diomedi Marina , Tomasi Santino O , Palmisciano Paolo , Umana Giuseppe E , Strigari Lidia , Griessenauer Christoph J , Pitocchi Francesca , Garaci Francesco , Floris Roberto 
Published: June 2022

Background The optimal management of patients with acute ischemic stroke (AIS) due to tandem occlusion (TO) and underlying carotid dissection (CD) remains unclear. Objective We present our multicenter-experience of endovascular treatment (EVT) approach used and outcomes for AIS patients with CD-related TO (CD-TO). Methods Consecutive AIS patients underwent EVT for CD-TO at five Italian Neuro-interventional Tertiary Stroke Centers were retrospectively identified. TO from atherosclerosis and other causes of, were excluded from the final analysis. Primary outcome was successful (mTICI 2b-3) and complete reperfusion (mTICI 3); secondary outcome was patients’ 3-months functional independence (mRS≤2). Results Among 214 AIS patients with TO, 45 presented CD-TO. Median age was 54 years (range 29–86), 82.2% were male. Age <65 years ( p < 0.0001), lower baseline NIHSS score ( p = 0.0002), and complete circle of Willis ( p = 0.0422) were associated with mRS ≤ 2 at the multivariate analysis. Comparisons between antegrade and retrograde approaches resulted in differences for baseline NIHSS scores ( p = 0.001) and number of EVT attempts per-procedure ( p = 0.001). No differences in terms of recanalization rates were observed between antegrade and retrograde EVT approaches ( p = 0.811) but higher rates of mTICI3 revascularization was observed with the retrograde compared to the antegrade approach (78.6% vs 73.3%), anyway not statistically significant. CD management technique (angioplasty vs aspiration vs emergent stenting) did not correlate with 3-months mRS≤2. Conclusion AIS patients with CD-TO were mostly treated with the retrograde approach with lower number of attempts per-procedure but it offered similar recanalization rates compared with the antegrade approach. Emergent carotid artery stenting (CAS) proved to be safe for CD management but it does not influence 3-months patients’ clinical outcomes.