bluuebunny/crossref_metadata_2025_split huggingface dataset:
Características fisicoquímicas y sensoriales de leches saborizadas elaboradas con leche caprina y bovina
Authors: Barquero-Saldarriaga Luis Miguel , Chacón-Villalobos Alejandro 
Published: January 2022

Introducción. La leche de cabra es un producto de alto valor nutracéutico y alimenticio, en torno al cual no hay una cultura de consumo establecida en varios países, por lo que su empleo en el desarrollo de nuevos productos es prometedor. Objetivo. Definir el efecto de diferentes proporciones de leche caprina y bovina sobre las propiedades fisicoquímicas y sensoriales de leches saborizadas. Materiales y métodos. En el Centro Nacional de Ciencia y Tecnología de Alimentos de la Universidad de Costa Rica, durante el 2021, se formularon leches saborizadas de tres sabores diferentes con cinco niveles de inclusión de leche caprina y bovina (0 %, 25 %, 50 %, 75 %, 100 %). Sobre estas se evaluaron el pH, acidez total, color instrumental (parámetros L*, b* y a*) y viscosidad, así como el agrado general, por medio de un panel con 110 jueces. Resultados. Al aumentar la proporción de leche caprina se registró en muchos de los casos, una disminución de pH y un aumento en la acidez en todas las muestras, así como un aumento en la viscosidad de las leches chocolatadas. El color en cada formulación no mostró diferencias en los parámetros a* y b* y L*, al variar las proporciones de leches. El análisis sensorial generó tres conglomerados de panelistas (15,5 %, 48,1 % y 36,4 %). Conclusión. La leche saborizada de fresa con una relación de leche bovina/leche caprina al 50 %, fue la que presentó la mejor combinación de parámetros fisicoquímicos y sensoriales.
Implementation of different separation techniques for resolving ternary mixture of Paracetamol, Pseudoephedrine Hydrochloride and Chlorpheniramine maleate with further quantification
Authors: Farid Joliana F. , Mostafa Nadia M. , Essam Hebatallah M. , Fayez Yasmin M. 
Published: January 2022

Abstract
Due to the wide applicability of separation techniques that rely on the property of differential migration in pharmaceutical formulations analysis, different analytical strategies have been proposed to resolve mixtures of multi-components pharmaceuticals. Three separation methods were developed and validated for the simultaneous determination of Paracetamol (PAR), Pseudoephedrine HCl (PSE) and Chlorpheniramine maleate (CHP). The first method is a thin-layer chromatographic (TLC) separation, followed by densitometric measurement. The separation was carried out on aluminium sheet of silica gel 60 F254 using ethanol:chloroform:ammonia (1:7:0.4, by volume) as the mobile phase. Determination of PAR, PSE and CHP was successfully applied over the concentration ranges of 3–25 µg/band, 0.5–10 µg/band and 0.1–6 µg/band, respectively. The second method is HPLC separation that was achieved on C18 column using the mobile phase acetonitrile:phosphate buffer pH 5 (10:90, v/v) at a flow rate 1 mL min−1. PAR, PSE and CHP were determined by HPLC in concentration ranges of 5–400 μg mL−1, 2–40 μg mL−1 and 0.5–16 μg mL−1, respectively. The third method is a capillary electrophoresis (CE) separation. The electrophoretic separation was achieved using 20 mM phosphate buffer (pH 6.5) at 20 kV. The linearity was reached over concentration ranges of 30–250 μg mL−1, 5–50 μg mL−1 and 0.8–20 μg mL−1 for PAR, PSE and CHP, respectively. The developed methods were validated with respect to linearity, precision, accuracy and system suitability. The proposed methods were successfully applied for bulk powder and dosage form analysis with RSD of precision <2%. Moreover, statistical comparison with the official methods confirms the methods' validity.
Quality risk assessment and DoE – Practiced validated stability-indicating chromatographic method for quantification of Rivaroxaban in bulk and tablet dosage form
Authors: Palandurkar Kamlesh , Bhandre Richie , Boddu Sai H. S. , Harde Minal , Lakade Sameer , Kandekar Ujjwala , Waghmare Prashant 
Published: January 2022

AbstractA systematic DoE and Analytical Quality by Design (AQbD) approach was utilized for the development and validation of a novel stability indicating high-performance thin–layer chromatographic (HPTLC) method for Rivaroxaban (RBN) estimation in bulk and marketed formulation. A D-optimal design was used to screen the effect of solvents, volume of solvents, time from spotting to development and time for development to scanning. ANOVA results and Pareto chart revealed that toluene, methanol, water and saturation time had an impact on retention time. The critical method and material attributes were further screened by Box-Behnken design (BBD) to achieve optimal chromatographic condition. A stress degradation study was carried out and structure of major alkaline degradant was elaborated. According to the design space, a control strategy was used with toluene: methanol: water (6:2:2) and the saturation time was 15 min. A retention factor (RF) of 0.59 ± 0.05 was achieved for RBN using chromatographic plate precoated with silica gel at detection wavelength 282 nm with optimized conditions. The linear calibration curve was achieved in the concentration range of 200–1,200 ng/band with r2 > 0.998 suggesting good coordination between analyte concentration and peak areas. The quadratic model was demonstrated as the best fit model and no interaction was noted between CMAs. The optimized HPTLC method was validated critically as stated in International Conference on Harmonization (ICH) Q2 (R1) guideline and implemented successfully for stress degradation study of RBN. The developed HPTLC method obtained through AQbD application was potentially able to resolve all degradants of RBN achieved through forced degradation study. The obtained results demonstrate that a scientific AQbD approach implementation in HPTLC method development and stress degradation study drastically minimizes the number of trials in experiments, ultimately time and cost of analysis could be minimized.
Day‐ahead forecasting of losses in the distribution network
Authors: Dalal Nisha , Mølnå Martin , Herrem Mette , Røen Magne , Gundersen Odd Erik 
Published: January 2022

AbstractUtility companies in the Nordics have to nominate how much electricity is expected to be lost in their power grid the next day. We present a commercially deployed machine learning system that automates this day‐ahead nomination of the expected grid loss. It meets several practical constraints and issues related to, among other things, delayed, missing and incorrect data and a small data set. The system incorporates a total of 24 different models that performs forecasts for three sub‐grids. Each day one model is selected for making the hourly day‐ahead forecasts for each sub‐grid. The deployed system reduced the mean average percentage error (MAPE) with 40% from 12.17 to 7.26 per hour from mid‐July to mid‐October, 2019. It is robust, flexible and reduces manual work. Recently, the system was deployed to forecast and nominate grid losses for two new grids belonging to a new customer. As the presented system is modular and adaptive, the integration was quick and needed minimal work. We have shared the grid loss data‐set on Kaggle.
Considerations on creating conversational agents for multiple environments and users
Authors: Cebrián Javier , Martínez Ramón , Rodríguez Natalia , D'Haro Luis Fernando 
Published: January 2022

AbstractAdvances in artificial intelligence algorithms and expansion of straightforward cloud‐based platforms have enabled the adoption of conversational assistants by both, medium and large companies, to facilitate interaction between clients and employees. The interactions are possible through the use of ubiquitous devices (e.g., Amazon Echo, Apple HomePod, Google Nest), virtual assistants (e.g., Apple Siri, Google Assistant, Samsung Bixby, or Microsoft Cortana), chat windows on the corporate website, or social network applications (e.g. Facebook Messenger, Telegram, Slack, WeChat).Creating a useful, personalized conversational agent that is also robust and popular is nonetheless challenging work. It requires picking the right algorithm, framework, and/or communication channel, but perhaps more importantly, consideration of the specific task, user needs, environment, available training data, budget, and a thoughtful design.In this paper, we will consider the elements necessary to create a conversational agent for different types of users, environments, and tasks. The elements will account for the limited amount of data available for specific tasks within a company and for non‐English languages. We are confident that we can provide a useful resource for the new practitioner developing an agent. We can point out novice problems/traps to avoid, create consciousness that the development of the technology is achievable despite comprehensive and significant challenges, and raise awareness about different ethical issues that may be associated with this technology. We have compiled our experience with deploying conversational systems for daily use in multicultural, multilingual, and intergenerational settings. Additionally, we will give insight on how to scale the proposed solutions.
Hematologic Involvement as a Predictor of Mortality in COVID-19 Patients in a Safety Net Hospital
Authors: Gonzalez-Mosquera Luis F. , Gomez-Paz Sandra , Lam Eric , Cardenas-Maldonado Diana , Fogel Joshua , Adi Vishnu , Rubinstein Sofia 
Published: January 2022

Introduction. COVID-19 affects the hematologic system. We evaluate the impact of hematologic involvement of different blood cell line parameters of white blood cells including absolute neutrophil count (ANC), hemoglobin, and platelets in COVID-19 patients and their association with hospital mortality and length of stay (LOS).
Methods. This is a retrospective study of 475 patients with confirmed positive COVID-19 infection and hematologic abnormalities in the metropolitan New York City area.
Results. Increased (ANC) (OR:1.20; 95% CI:1.02-1.42, p<0.05) increased days to hematologic involvement (OR:4.44, 95% CI:1.42-13.90; p<0.05), and persistence of hematologic involvement at discharge (OR:2.87, 95% CI:1.20, 6.90, p<0.05) were associated with higher mortality. Higher hemoglobin at admission (OR:0.77, 95% CI:0.60-0.98, p<0.001) and platelets peak (OR:0.995, 95% CI 95%:0.992-0.997, p<0.001) were associated with decreased mortality. Patients with higher white blood cell peak (B=0.46, SE=0.07, p<0.001) and higher hemoglobin at admission (B=0.05, SE=0.01, p<0.001) were associated with higher LOS. Those with higher hemoglobin nadir (B=-0.06, SE=0.01, p<0.001), higher platelets nadir (B=-0.001, SE=<0.001, p<0.001), and hematologic involvement at discharge/death (B=-0.06, SE=0.03, p<0.05) were associated with lower LOS.
Conclusions. These findings can be used by clinicians to better risk-stratify patients with hematologic involvement in COVID-19 and tailor therapies to potentially improve patient outcomes.
Mental Health and Access to Medical Care in Patients with Chronic Cardiovascular Conditions: An Analysis of the Behavior Risk Factor Surveillance System
Authors: Kherallah Riyad , Al Rifai Mahmoud , Liu Jing , Kianoush Sina , Misra Arunima , Virani Salim 
Published: January 2022

Introduction. Poor mental health is associated with worse outcomes for chronic diseases. It is unclear whether mental illness predisposes to difficulties with healthcare access.
Methods. Using a combined dataset of the 2016-2019 behavioral risk factor surveillance system, we included individuals who reported a chronic cardiovascular condition. Weighted multivariable logistic regression analyses were used to explore the association between domains of mental health and measures of healthcare access including delaying medical care, > 1 year since last routine checkup, lack of a primary care physician (PCP), and cost-related medication nonadherence (CRMNA).
Results. Among 1,747, 397 participants, 27% had a chronic cardiovascular condition, 12% had clinical depression, and 12% had poor mental health. Those with poor mental health (OR 3.20 [3.08 – 3.33]) and clinical depression (OR 2.43 [2.35 – 2.52]) were more likely to report delays in medical care. Those with greater stress frequency (OR 8.47 [6.84 -10.49] stressed all of the time), lower levels of emotional support received (OR 3.07 [2.21 – 4.26] rarely get needed emotional support), and greater life dissatisfaction (6.66 [4.14 – 10.70] very dissatisfied) reported greater delays in medical care.
Conclusions. Individuals with poor mental health have greater difficulty accessing medical care independent of socioeconomic variables.
МОЛОДЕЖНЫЕ ОБЩЕСТВЕННЫЕ ОБЪЕДИНЕНИЯ В РЕАЛИЗАЦИИ ГОСУДАРСТВЕННОЙ НАЦИОНАЛЬНОЙ ПОЛИТИКИ НА ЮГЕ РОССИИ: СУБЪЕКТНОСТЬ И СОЦИАЛЬНАЯ ЭФФЕКТИВНОСТЬ
Authors: Бедрик Андрей Владимирович , Зайцева Анастасия Андреевна , Панфилова Юлия Сергеевна , Щукина Елена Львовна 
Published: January 2022

Аннотация. Цель исследования — оценить социальную эффективность деятельности молодежных общественных объединений, занимающихся реализацией приоритетных направлений государственной национальной политики и степень их субъектности. Для достижения поставленной цели был использован метод глубинных интервью с субъектами реализации национальной политики (20 информантов) и лидерами молодежных общественных объединений (30 информантов) в Крыму, Краснодарском крае и Ростовской области.
Методологическая база исследования включает рассмотрение социальной эффективности деятельности молодежных общественных объединений с точки зрения структурно-функционального подхода, с позиции социального конструктивизма, а понимание социальной субъектности — в контексте теории Вал. А. Лукова.
Результаты исследования. Говоря о социальной эффективности деятельности молодежных общественных объединений, участвующих в реализации государственной национальной политики, необходимо разделить это понятие на широкий и узкий смысл. В широком смысле деятельность этих объединений эффективной назвать можно не всегда, в первую очередь потому, что в нее вовлечен достаточно узкий сегмент молодежи. Если же говорить о работе с целевыми выборками аудитории, то здесь их деятельность эффективна: они выступают регуляторами отношений между молодежью диаспор, популяризируют культуру этносов среди студентов, выступают агентами социальной адаптации молодых мигрантов, работают как медиаторы и каналы социальной мобильности. Что касается субъектности этих объединений, то сегодня она находится на достаточно высоком уровне: инициация их создания идет «снизу», они имеют развитую сеть партнерских отношений, инициируют инновационные социальные проекты. При этом оценки перспектив развития субъектности данных объединений среди экспертов разнятся: часть видит в них большой потенциал, часть отмечает препятствия в развитии субъектности, связанные с наличием у них большого спектра проблем.
Перспективы исследования: разработка комплекса рекомендаций для повышения эффективности деятельности молодежных общественных объединений в сфере реализации приоритетных направлений государственной национальной политики.
СОЦИАЛЬНАЯ СПРАВЕДЛИВОСТЬ В КОЛЛЕКТИВНЫХ ПРЕДСТАВЛЕНИЯХ ЭТНИЧЕСКИХ ГРУПП КРАСНОДАРСКОГО КРАЯ
Authors: Войтенко Валерия Петровна , Пантелеев Вадим Геннадьевич 
Published: January 2022

Аннотация. Целью исследования является выявление коллективных представлений этнических групп, проживающих в Краснодарском крае, о социальной справедливости.
Методологическую базу исследования представляет определение респондентом предпочитаемого им основания социальной справедливости посредством оценки суждений, характеризующих эти основания, способом выбора парной альтернативы (согласен / не согласен). В статье использовались такие научные методы, как каузальный анализ, сравнительный анализ, анализ статистики эмпирического социологического исследования.
Результаты исследования. В результате анализа и сопоставления эмпирических данных была выявлена специфика представлений о социальной справедливости этносов, проживающих на территории Краснодарского края — армян, русских, турок-месхетинцев, шапсугов. Главными основаниями социальной справедливости у армян оказались законность, помощь нуждающимся «всем миром», равные условия развития каждого, вознаграждение по заслугам. У русских такими основаниями оказались законность, равные условия развития каждого, вознаграждение по заслугам, помощь нуждающимся «всем миром». У турок-месхетинцев — равные условия развития каждого, помощь нуждающимся «всем миром», законность, отсутствие разделения на богатых и бедных. У шапсугов — равные условия развития каждого, помощь нуждающимся «всем миром», законность, вознаграждение по заслугам. Выявлены отличия представлений социальной справедливости по линии урбанизированности и религиозной принадлежности этносов.
Перспективы исследования заключаются в дальнейшем углублении изучения того, какие представления о социальной справедливости присущи тем или иным этническим группам. Результаты исследования могут быть использованы в разработке национальной политики по отношению к конкретным этническим группам.
ИНОСТРАННЫЕ СТУДЕНТЫ И ПРИНИМАЮЩЕЕ СООБЩЕСТВО ВУЗА: ОСОБЕННОСТИ ВОСПРИЯТИЯ И ПРАКТИКИ ВЗАИМОДЕЙСТВИЯ
Authors: Карташевич Екатерина Владимировна , Чикарова Галина Игоревна , Гаврилов Павел Сергеевич 
Published: January 2022

Аннотация. Цель статьи: выявить характер взаимоотношений между иностранными студентами — образовательными (учебными) мигрантами и представителями принимающего сообщества вуза, в котором они проходят обучение.
Эмпирическая база включает в себя результаты прикладного социологического исследования, проведенного коллективом Южно-Российского филиала ФНИСЦ РАН в 2021 году методом анкетного опроса иностранных студентов вузов Юга России.
Результаты. Несмотря на то, что для иностранных студентов, обучающихся в вузах ЮФО, характерно позитивное отношение к представителям принимающего сообщества на уровне социально-психологических установок, сформированных еще до прибытия в страну обучения и сохраняющихся в процессе обучения и непосредственного пребывания в новом для себя обществе, и сложившиеся эффективные практики взаимодействия учебных мигрантов с представителями принимающего сообщества посредством расширения внеучебной деятельности вузов, все же учебные мигранты ЮФО, ставшие участниками проводимого исследования, демонстрируют преобладание в поведении стратегии ограничения взаимодействий с принимающим сообществом, что может быть барьером на пути реализации миграционной политики РФ.
Перспективы исследования. Предложенное исследование подчеркивает необходимость рассмотрения образовательных (учебных) мигрантов как самостоятельной социальной группы в контексте изучения таких социальных процессов, как адаптация и интеграция мигрантов.
Effect of pregravid preparation of HIV-infected couples on perinatal outcomes
Authors: Ovchinnikova A. O. , Mikhalchenko S. V. , Kaganova M. A. , Chernova O. E. 
Published: January 2022

Objective. To assess the levels of viral load, immune status as well as labor outcome depending on the absence or presence of pregravid preparation with the partner and without the latter.
Materials and methods. This cohort study included 90 women of reproductive age with stages 3 and 4A HIV infection. To compare the groups, Kruskal Wallis, Mann Whitney tests and correlation analysis were applied.
Results. The pregravid preparation of HIV-infected women without a partner was detected to three-fold decrease a viral load in the I trimester of pregnancy (p = 0.001), two-fold in the II trimester (p = 0.02) and three-fold in the III trimester (p = 0.002); with a partner a two-fold decrease in the I trimester (p = 0.0018). The pregravid preparation of HIV-infected women reduces the probability of giving birth to a child with low body mass (p = 0.023); with a partner it decreases the risk for the preterm labor (p = 0.02).
Conclusions. Thus, the presence of pregravid preparation in HIV-infected women, with a partner as well, decreases the probability of giving birth to a child with low body mass and preterm labor.
NIOM Analysis of Earthquake Observation Records in a Rockfill Dam
Authors: Mogi Hidenori , Kawakami Hideji 
Published: January 2022

ABSTRACTWe applied the normalized input–output minimization method (a method developed for the analysis of propagation times in vertical array records) to long-term earthquake observation records from Aratozawa Dam (in Kurihara, Miyagi prefecture, Japan), spanning the period from July 1992 to December 2019 to determine the propagation velocity of seismic waves in the embankment, and investigated changes in soil properties. As a result, we showed that (1) the velocities of S and P waves in the upper section were 449 and 993 m/s, respectively, prior to the strong earthquake motions derived from earthquake records from January 1997 through October 2001, whereas 608 and 1538, respectively, in the lower section, (2) in the Iwate–Miyagi Nairiku earthquake, the S-wave velocity in the upper section decreased to 158 m/s in the principal shock, and (3) in subsequent minor earthquakes the propagation velocity increased more or less in proportion with the logarithm of the number of elapsed days, requiring three years or longer to return to the initial value, (4) although similar changes were observed in the Great East Japan earthquake of 2011, the reduction in propagation velocity that remained after the principal shock was smaller than in the case of the Iwate–Miyagi Nairiku earthquake, and it was judged that there were no large effects on the dam body such as those that occurred in the Iwate–Miyagi Nairiku earthquake, and furthermore (5) in the principal shock of the Iwate–Miyagi Nairiku earthquake, the shear modulus in the upper part of the dam body decreased from 400 to 50 MPa (with a maximum shear strain of 10−3), resulting in more pronounced changes than in the lower section, whereas the damping ratio increased by at least 10% in the lower section during the principal shock of the Iwate–Miyagi Nairiku earthquake, resulting in much greater changes than in the upper section.
Seismic Source Processes of 25 Earthquakes (Mw&gt;5) in the Gulf of California
Authors: Huesca-Pérez Eduardo , Gutierrez-Reyes Edahí , Quintanar Luis 
Published: January 2022

ABSTRACT
The Gulf of California (GoC) is a complex tectonic boundary that has been instrumented in the past several decades to record broadband seismograms. This volume of data has allowed us to study several source parameters systematically. Before, only a few source parameters of earthquakes greater than magnitude five had been studied in the GoC area. We re-examined the focal mechanisms of several earthquakes in the southern GoC that occurred over the last 20 yr using local–regional distance broadband seismograms. These focal mechanisms were then used as input data to retrieve the time–space history of the rupture for each earthquake. This work contributes to the study of 25 rupture-process models computed with the method proposed by Yagi et al. (1999). To investigate more about the nature of the seismicity in the GoC, we also calculated the non-double-couple component of moment tensors for 45 earthquakes. Previous studies (e.g., Ortega et al., 2013, 2016) have shown that non-double-couple components from moment tensors in this region are associated with complex faulting, suggesting that oblique faults or several parallel faults are interacting simultaneously. Our results show that, at least for moderate earthquakes (5 &lt; M &lt; 6), rupture processes in the GoC show a complex interaction between fault systems. It is revealed on the important contribution of non-double-couple component obtained in the full moment tensor analysis.