bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding Social Exclusion of the Low-caste Muslims in Kashmir
Authors: Shah Hafsa Sayeed 
Published: February 2022

This paper attempts to establish the prevalence of the caste system among Muslims in Kashmir. This has been achieved by pointing to aspects like endogamy, ghettoization as well as hereditary passing of ‘menial’ jobs among the ‘low caste’ groups. Further, these findings have been substantiated by the fieldwork done over three months. The essential premise borrowed here to understand caste in Kashmir is that of social exclusion, which the low-caste groups face. Social exclusion, in the context of this study, can be understood as a process that places certain caste groups in a disadvantaged position. This especially stems from being kept out of the larger social networks, in addition to not being able to access employment and education. It is also rooted in the overlapping layers of socio-cultural and economic deprivation. Poverty, in terms of material depravity, is starkly reinforced by such a socio-cultural identity of being a low-caste person employed in a ‘menial’ job. The objective of this paper, as such, is to theorize social exclusion faced by low-caste groups in Kashmir through a capability framework. This paper also investigates the importance of relational deprivation which leads to the capability failure and hence poverty, as well as the dynamics of caste-class interaction in the similar framework of social exclusion.
Comparative investigation of the influence of stone-dust particles and bagasse fiber on the mechanical and physical properties of reinforced recycled high-density polyethylene bio-composites
Authors: Oladele Isiaka Oluwole , Aliu Simbiat Olawunmi , Taiwo Anuoluwapo Samuel , Agbeboh Newton Itua 
Published: February 2022

One of the main purposes of this research is to control environmental pollution and mitigate the impact of ignorantly discarded waste plastics in the environment through recycling of such plastics and using them to develop innovative composite materials. The present work investigates the influence of stone-dust particles and bagasse fiber on the mechanical and physical properties of reinforced recycled high-density polyethylene bio-composites. The bagasse fiber was first treated with 0.5 m NaOH solution at a temperature of 50°C for 2 h in order to improve the surface morphology and also modified the mechanical properties of the fiber. Likewise, the stone-dust particles were analyzed by using a standard sieve shaker to obtain particle sizes of 75 μm. Both reinforcements were used for composite development through the compression molding technique and the samples were subjected to mechanical and physical properties tests in accordance with standards. Analysis of the results revealed that flexural, hardness, wear, and hydrophobicity of the developed bio-composites were improved by stone-dust particles. The flexural strength at peak and modulus were enhanced by 88% and 92%, respectively. Also, it was discovered that, tensile, impact and thermal conductivity properties of the bio-composites were improved by bagasse fiber. The ultimate tensile strength and Young’s modulus were enhanced by 43% and 34%, respectively. Hence, the blend of these by-products showed that they are potential bio-materials for the development of bio-composites.
Clinical Evaluation of the Hip With Focus on Assessment of Hip Instability
Authors: Turner Elizabeth H. G. , Watchmaker Lauren E. , Spiker Andrea M. 
Published: February 2022

Background: Hip instability is a challenging clinical diagnosis, which often overlaps with the presentation of hip impingement and/or hip dysplasia. Many factors contribute to hip instability, including acetabular undercoverage, femoroacetabular-impingement-induced instability, and soft tissue laxity. It can cause significant pain and disability, either as a primary pathology or as a complication of surgery and if untreated can ultimately lead to early osteoarthritis. Indications: Hip dysplasia is often diagnosed with an anterior-posterior pelvic radiograph. The literature has supported a normal lateral center edge angle (LCEA) as ≥25°, borderline dysplasia an LCEA of 18° to 25°, and an LCEA <18° as true dysplasia, though some authors will diagnose borderline dysplasia as an LCEA of 20° to 25° and true dysplasia as an LCEA <20°. In addition, there are many radiographic measurements that have been described to aid in the diagnosis of hip instability beyond LCEA, including the acetabular inclination (or Tönnis angle), the femoro-epiphyseal acetabular roof (FEAR) index, and the cliff sign. Technique Description: Hip instability can be present even in the absence of radiographic findings, and many with insufficient coverage of the femoral head do not meet the radiographic definition of dysplasia. For this reason, it is important to have an understanding of the clinical assessment that may aid in the diagnosis of hip instability. Here, we present our preferred technique for clinical examination of the hip, focusing on the assessment of hip instability. Results: While no one maneuver is sufficient to diagnose hip instability, incorporation of multiple examinations in conjunction with radiographs can help to properly diagnose the presence of hip instability. Discussion/Conclusion: Hip instability is a challenging clinical diagnosis, and many examination maneuvers have been described to assess for hip instability. In this technical note, we describe our preferred technique for clinical examination of the hip, focusing on the assessment of hip instability.
Analysis of racial and ethnic disparities in multiple myeloma US FDA drug approval trials
Authors: Kanapuru Bindu , Fernandes Laura L. , Fashoyin-Aje Lola A. , Baines Andrea C. , Bhatnagar Vishal , Ershler Rachel , Gwise Thomas , Kluetz Paul , Pazdur Richard , Pulte Elizabeth , Shen Yuan-Li , Gormley Nicole 
Published: February 2022

Abstract
African Americans (AAs) have a higher incidence of multiple myeloma (MM) than White patients. Mortality is also higher in AAs compared with White patients. AAs more commonly have immunoglobulin H translocations t(11;14) and t(14;16) compared with White patients. We sought to characterize the demographic representation in MM clinical trials and evaluate outcomes based on race and ethnicity. We conducted a pooled analysis of all trials submitted to the US Food and Drug Administration (FDA) to support approval of a MM therapeutic between 2006 and 2019. Demographic characteristics were analyzed descriptively. An age-adjusted stratified Cox regression model was used to evaluate the relationship between time-to-event outcomes and race and ethnicity. Nineteen global trials comprising 10 157 patients were pooled. White, Asian, and Black patients comprised 84%, 7%, and 4% of the dataset, respectively; Hispanic patients comprised 4%. The age-adjusted overall survival hazard ratio (HR) for Black compared with White patients was 0.89 (95% confidence interval [CI], 0.75-1.05). The age-adjusted HR for US Black vs US White patients was 0.82 (95% CI, 0.66-1.02). For rest-of-world (RoW) Black vs RoW White patients, the HR was 1.31 (95% CI, 0.97-1.77). Black and Hispanic patients were underrepresented in the trials supporting FDA approval of MM drugs. Black patients were primarily enrolled in the United States. Outcomes in US patients were more favorable compared with those in patients in the RoW. Given the higher incidence of MM in AAs and the different disease characteristics, efforts should be made to improve representation of AAs in MM clinical trials.
Assessing cough symptom severity in refractory or unexplained chronic cough: findings from patient focus groups and an international expert panel
Authors: Kum Elena , Guyatt Gordon H. , Munoz Caroline , Beaudin Suzanne , Li Shelly-Anne , Abdulqawi Rayid , Badri Huda , Boulet Louis-Philippe , Chen Ruchong , Dicpinigaitis Peter , Dupont Lieven , Field Stephen K. , French Cynthia L. , Gibson Peter G. , Irwin Richard S. , Marsden Paul , McGarvey Lorcan , Smith Jaclyn A. , Song Woo-Jung , O'Byrne Paul M. , Satia Imran 
Published: February 2022

BackgroundCough symptom severity represents an important subjective end-point to assess the impact of therapies for patients with refractory or unexplained chronic cough (RCC/UCC). As existing instruments assessing the severity of cough are neither widely available nor tested for measurement properties, we aim to develop a new patient-reported outcome measure addressing cough severity.ObjectiveThe aim of this study was to establish items and domains that would inform development of a new cough severity instrument.MethodsThree focus groups involving 16 adult patients with RCC/UCC provided data that we analysed using directed content analysis. Discussions led to consensus among an international panel of 15 experts on candidate items and domains to assess cough severity.ResultsThe patient focus group provided 48 unique items arranged under broad domains of urge-to-cough sensations and cough symptom. Feedback from expert panel members confirmed the appropriateness of items and domains, and provided an additional subdomain related to cough triggers. The final conceptual framework comprised 51 items in the following domains: urge-to-cough sensations (subdomains: frequency and intensity) and cough symptom (subdomains: triggers, control, frequency, fit/bout duration, intensity, quality and associated features/sequelae).ConclusionsConsensus findings from patients and international experts established domains of urge-to-cough and cough symptom with associated subdomains and relevant items. The results support item generation and content validity for a novel patient-reported outcome measure for use in health research and clinical practice.
Spatio-temporal variation of bacterioplankton community structure in the Pearl River: impacts of artificial fishery habitat and physicochemical factors
Authors: Bi Sheng , Lai Han , Guo Dingli , Liu Xuange , Wang Gongpei , Chen Xiaoli , Liu Shuang , Yi Huadong , Su Yuqin , Li Guifeng 
Published: February 2022

Abstract
Background
Artificial fishery habitat has been widely used in fishery resource protection and water habitat restoration. Although the bacterioplankton plays an important ecological role in fisheries ecosystems, the effect of artificial fishery habitat on bacterioplankton is not clear. In this study, high-throughput sequencing based on the 16S rRNA gene was carried out to study the characteristics of bacterioplankton community structure in artificial fishery habitat and to determine the principal environmental factors that shaped the composition, structure and function of bacterioplankton communities in an unfed aquaculture system.

Results
The results indicated that the most dominant phyla were Proteobacteria (Alphaproteobacteria and Gammaproteobacteria), Actinobacteria, Cyanobacteria, and Bacteroidetes, which accounted for 28.61%, 28.37%, 19.79%, and 10.25% of the total abundance, respectively. The factors that cause the differences in bacterioplankton community were mainly manifested in three aspects, including the diversity of the community, the role of artificial fishery habitat, and the change of environmental factors. The alpha diversity analysis showed that the diversity and richness index of the bacterioplankton communities were the highest in summer, which indicated that the seasonal variation characteristics had a great influence on it. The CCA analysis identified that the dissolved oxygen, temperature, and ammonium salt were the dominant environmental factors in an unfed aquaculture system. The LEfSe analysis founded 37 indicator species in artificial structure areas (AS group), only 9 kinds existing in the control areas of the open-water group (CW group). Meanwhile, the KEGG function prediction analysis showed that the genes which were related to metabolism in group AS were significantly enhanced.

Conclusions
This study can provide reference value for the effect of artificial habitat on bacterioplankton community and provide fundamental information for the follow-up study of ecological benefits of artificial fishery habitat. It may be contributed to apply artificial fishery habitat in more rivers.
Yoghurt consumption is associated with changes in the composition of the human gut microbiome and metabolome
Authors: Le Roy Caroline Ivanne , Kurilshikov Alexander , Leeming Emily R. , Visconti Alessia , Bowyer Ruth C. E. , Menni Cristina , Falchi Mario , Koutnikova Hana , Veiga Patrick , Zhernakova Alexandra , Derrien Muriel , Spector Tim D. 
Published: February 2022

Abstract
Background
Yoghurt contains live bacteria that could contribute via modulation of the gut microbiota to its reported beneficial effects such as reduced body weight gain and lower incidence of type 2 diabetes. To date, the association between yoghurt consumption and the composition of the gut microbiota is underexplored. Here we used clinical variables, metabolomics, 16S rRNA and shotgun metagenomic sequencing data collected on over 1000 predominantly female UK twins to define the link between the gut microbiota and yoghurt-associated health benefits.

Results
According to food frequency questionnaires (FFQ), 73% of subjects consumed yoghurt. Consumers presented a healthier diet pattern (healthy eating index: beta = 2.17 ± 0.34; P = 2.72x10−10) and improved metabolic health characterised by reduced visceral fat (beta = −28.18 ± 11.71 g; P = 0.01). According to 16S rRNA gene analyses and whole shotgun metagenomic sequencing approach consistent taxonomic variations were observed with yoghurt consumption. More specifically, we identified higher abundance of species used as yoghurt starters Streptococcus thermophilus (beta = 0.41 ± 0.051; P = 6.14x10−12) and sometimes added Bifidobacterium animalis subsp. lactis (beta = 0.30 ± 0.052; P = 1.49x10−8) in the gut of yoghurt consumers. Replication in 1103 volunteers from the LifeLines-DEEP cohort confirmed the increase of S. thermophilus among yoghurt consumers. Using food records collected the day prior to faecal sampling we showed than an increase in these two yoghurt bacteria could be transient. Metabolomics analysis revealed that B. animalis subsp. lactis was associated with 13 faecal metabolites including a 3-hydroxyoctanoic acid, known to be involved in the regulation of gut inflammation.

Conclusions
Yoghurt consumption is associated with reduced visceral fat mass and changes in gut microbiome including transient increase of yoghurt-contained species (i.e. S. thermophilus and B. lactis).
Development and multi-center clinical trials of an up-converting phosphor technology-based point-of-care (UPT-POCT) assay for rapid COVID-19 diagnosis and prediction of protective effects
Authors: Zhang Pingping , Li Baisheng , Wang Yao , Min Wei , Wang Xiaohui , Zhou Yugui , Li Zhencui , Zhao Yong , Zhang Huan , Jiang Min , Zheng Huanying , Yang Chao , Zhang Wei , Zuo Le , Gao Qi , Yang Zhengrong , Li Yanzhao , Feng Tiejian , Lin Changqing , Hu Qinghua , Song Tie , Yang Ruifu 
Published: February 2022

Abstract
Background
Quantitative point-of-care testing assay for detecting antibodies is critical to COVID-19 control. In this study, we established an up-conversion phosphor technology-based point-of-care testing (UPT-POCT), a lateral flow assay, for rapid COVID-19 diagnosis, as well as prediction of seral neutralizing antibody (NAb) activity and protective effects.

Methods
UPT-POCT was developed targeting total antibodies against the receptor-binding domain (RBD) of SARS-CoV-2 spike protein. Using ELISA as a contrast method, we evaluated the quantitation accuracy with NAb and serum samples. Cutoff for serum samples was determined through 70 healthy and 140 COVID-19 patients. We evaluated the cross-reactions with antibodies against other viruses. Then, we performed multi-center clinical trials of UPT-POCT, including 782 patients with 387 clinically confirmed COVID-19 cases. Furthermore, RBD-specific antibody levels were detected using UPT-POCT and microneutralization assay for samples from both patients and vaccinees. Specifically, the antibodies of recovered patients with recurrent positive (RP) reverse transcriptase-polymerase chain reaction test results were discussed.

Results
The ratios of signal intensities between the test and control bands on the lateral flow strip, namely, T/C ratios, was defined as the results of UPT-POCT. T/C ratios had excellent correlations with concentrations of NAb, as well as OD values of ELISA for serum samples. The sensitivity and specificity of UPT-POCT were 89.15% and 99.75% for 782 cases in seven hospitals in China, respectively. We evaluated RBD-specific antibodies for 528 seral samples from 213 recovered and 99 RP COVID-19 patients, along with 35 seral samples from inactivated SARS-CoV-2 vaccinees, and we discovered that the total RBD-specific antibody level indicated by T/C ratios of UPT-POCT was significantly related to the NAb titers in both COVID-19 patients (r = 0.9404, n = 527; ρ = 0.6836, n = 528) and the vaccinees (r = 0.9063, ρ = 0.7642, n = 35), and it was highly relevant to the protection rate against RP (r = 0.9886, n = 312).

Conclusion
This study reveals that the UPT-POCT for quantitative detection of total RBD-specific antibody could be employed as a surrogate method for rapid COVID-19 diagnosis and prediction of protective effects.
“One-step” approach versus “Step-up” approach minimally invasive treatment for infected pancreatic necrosis: a study protocol for a single-center, prospective, randomized controlled trial
Authors: Zheng Zhi , Lu Jiongdi , Cao Feng , Ding Yixuan , Guo Yulin , Mei Wentong , Qu Yuanxu , Liu Shuang , Sun Haichen , Cui Yeqing , Li Ang , Li Fei 
Published: February 2022

Abstract
Background
Currently, the minimally invasive “Step-up” surgical strategy is still the main treatment for infected pancreatic necrosis (IPN). However, indiscriminate implementation of the “Step-up” strategy can lead to increased numbers of operations and prolonged hospital stay. The “Step-up” approach is not appropriate for some patients due to unavailabilty of a safe puncture path. Therefore, we developed the “One-step” surgical approach to treat IPN, which is safety. However, there is still a lack of comparison of the short and long-term efficacy between the “One-step” and “Step-up” approach. Consequently, we are conducting this clinical trial to provide a reference for IPN treatment.

Methods
This is an ongoing, single-center, randomized controlled trial of patients with IPN. The total sample size required for the trial (May 2021–December 2023) is approximately 128 patients. Patients will be randomly assigned to either an experimental group (One-step) or a control group (Step-up) at a ratio of 1:1 using the block randomization method. We used the case report forms and electronic data capture systems to obtain demographic information, preoperative laboratory examination, auxiliary examination results, surgery data, postoperative recovery outcomes, and follow-up outcomes. The patients will be followed up for 2 years after surgery. The primary endpoint is a composite endpoint, consisting of mortality and severe complications. The secondary endpoints include the incidence of organ dysfunction, the number of surgical procedures, mortality (the incidence of death in hospital and deaths within 30 days of discharge), hospital stay, intensive care unit stay, hospitalization costs, perioperative inflammatory marker changes, and short-and long-term complications.

Discussion
Compared with the “Step-up,” the “One-step” minimally invasive surgery can significantly reduce the number of operations, reduce the length of hospital stay and hospitalization costs without increasing the incidence of composite endpoint events, and has better short- and long-term efficacy and safety. Additionally, there was no statistically significant difference in perioperative complications and mortality between “Step-up” and “One-step”. This study will assist with the formulation of an effective and scientific “One-step” minimally invasive treatment strategy for IPN, and an understanding of this technique will facilitate clinical decision-making for IPN.
Trial Registration ChiCTR2100044348. Trial status: Ongoing.
An ultra-rare case of immunoskeletal dysplasia with neurodevelopmental abnormalities in an Indian patient with homozygous c.953C > T variant in EXTL3 gene: a case report
Authors: Bajaj Shruti , Satoskar Purnima , Nair Aadhira , Sheth Frenny , Sheth Jayesh , Sheth Harsh 
Published: February 2022

AbstractBackgroundImmunoskeletal dysplasia with neurodevelopmental abnormalities (ISDNA) is an ultra-rare genetic condition that belongs to the group of spondyloepimetaphyseal dysplasias. It is caused due to presence of biallelic variants in theEXTL3gene. The encoded exostosin like glycosyltransferase 3 (EXTL3) protein plays a key role in heparan sulfate synthesis. The skeletal and nervous systems are prominently affected in ISDNA with variability in immunological manifestations. Here, we report the 15thcase of ISDNA (third patient of an Indian ancestry) in the world, along with a review of literature.Case presentationA 15-month-old female child with clinical indications of global developmental delay, short stature, coarse facial features, and hypotonia was referred to our clinic. Spondyloepimetaphyseal dysplasias associated with extra-skeletal manifestations was suspected based on clinic-radiological correlation. Whole exome sequencing analysis revealed the presence of a homozygous known pathogenic variant c.953C > T (p. Pro318Leu) in exon 3 of theEXTL3gene, thereby confirming diagnosis of ISDNA.ConclusionWe present an ultra-rare case of ISDNA- third patient of Indian ancestry and only the 15threported case in the literature. On review of all cases in the literature, we find that the affected individuals show abnormalities primarily in three systems namely- skeletal, nervous and immune system. Notably, patients harbouring the same variant inEXTL3gene show phenotypic variability especially with respect to presence or absence of immunological manifestations, suggesting a role of unknown modifiers. Hence, it is currently not possible to correlate the variant position in theEXTL3gene with disease severity.
Who gets vaccinated in a measles-rubella campaign in Nepal?: results from a post-campaign coverage survey
Authors: Danovaro-Holliday M. Carolina , Rhoda Dale A. , Lacoul Mona , Prier Mary L. , Gautam Jhalak Sharma , Pokhrel Tara Nath , Dixit Sameer Mani , Rajbhandari Rajesh Man , Bose Anindya Sekhar 
Published: February 2022

Abstract
Background
Following the 2015 earthquake, a measles-rubella (MR) supplementary immunization activity (SIA), in four phases, was implemented in Nepal in 2015–2016. A post-campaign coverage survey (PCCS) was then conducted in 2017 to assess SIA performance and explore factors that were associated with vaccine uptake.

Methods
A household survey using stratified multi-stage probability sampling was conducted to assess coverage for a MR dose in the 2015–2016 SIA in Nepal. Logistic regression was then used to identify factors related to vaccine uptake.

Results
Eleven thousand two hundred fifty-three households, with 4870 eligible children provided information on vaccination during the 2015–2016 MR SIA. Overall coverage of measles-rubella vaccine was 84.7% (95% CI: 82.0–87.0), but varied between 77.5% (95% CI: 72.0, 82.2) in phase-3, of 21 districts vaccinated in Feb-Mar 2016, to 97.7% (CI: 95.4, 98.9) in phase-4, of the last seven mountainous districts vaccinated in Mar-Apr 2016. Coverage in rural areas was higher at 85.6% (CI: 81.9, 88.8) than in urban areas at 79.0% (CI: 75.5, 82.1). Of the 4223 children whose caregivers knew about the SIA, 96.5% received the MR dose and of the 647 children whose caregivers had not heard about the campaign, only 1.8% received the MR dose.

Conclusions
The coverage in the 2015–2016 MR SIA in Nepal varied by geographical region with rural areas achieving higher coverage than urban areas. The single most important predictor of vaccination was the caregiver being informed in advance about the vaccination campaign. Enhanced efforts on social mobilization for vaccination have been used in Nepal since this survey, notably for the most recent 2020 MR campaign.