bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabesity phenotype and the risks of cardiovascular disease and subclinical atherosclerosis: A prospective cohort study
Authors: Kong Lijie , Qi Yan , Ye Chaojie , Wang Yiying , Zhao Zhiyun , Li Mian , Wang Shuangyuan , Lin Hong , Xu Yu , Xu Min , Lu Jieli , Chen Yuhong , Wang Weiqing , Ning Guang , Bi Yufang , Wang Tiange 
Published: July 2022

AbstractObjectiveThe aim of this study was to investigate the associations of diabesity with incident cardiovascular disease (CVD) and subclinical atherosclerosis.MethodsThe prospective cohort study included 8,006 participants without baseline CVD. Diabesity was categorized as (i) normal glucose tolerance (NGT) with nonobesity; (ii) NGT with obesity; (iii) prediabetes with nonobesity; (iv) prediabetes with obesity; (v) diabetes with nonobesity; and (vi) diabetes with obesity. The hazard ratios (HRs) for incident CVD and odds ratios (ORs) for subclinical atherosclerosis associated with diabesity categories were examined.ResultsCompared with the category of NGT with nonobesity, the categories of NGT with obesity (HR 1.68; 95% CI: 1.10–2.57), diabetes with nonobesity (HR 1.42; 95% CI: 1.08–1.88), and diabetes with obesity (HR 1.78; 95% CI: 1.24–2.55) were associated with higher risks of CVD. Prediabetes with or without obesity conferred no excess risk for CVD but higher risks for subclinical atherosclerosis. The diabetes with obesity category was associated with the highest risk for elevated pulse pressure (OR 3.07; 95% CI: 2.06–4.58) and albuminuria (OR 3.39; 95% CI: 2.31–4.99), and diabetes with or without obesity showed comparable ORs for elevated brachial–ankle pulse wave velocity.ConclusionsThe association patterns between diabesity and CVD risks support the value of diabesity as a prevention target for CVD.
Inflammatory markers in pregnant women with periodontal diseases—Systematic review and network meta‐analysis
Authors: Kania Michal , Malinowski Krzysztof Piotr , Słowik Joanna , Władysiuk Magdalena , Szopa Magdalena 
Published: July 2022

AbstractPeriodontal diseases (PD) have been associated with adverse pregnancy outcomes. Several studies reported on cytokines concentrations and oxidative stress in periodontal patients during pregnancy. We aimed at reviewing systemic inflammatory markers concentrations and oxidative stress status in the serum of pregnant women with periodontal diseases (PD) and gestational diabetes mellitus (GDM). In this systematic review and network meta‐analysis, 5595 studies were screened. In the non‐GDM arm of 48 reviewed articles, 11 were included: six for CRP, two for TNF‐alpha, and three for total antioxidant capacity (TAOC). CRP and TNF‐alpha were higher in PD groups in comparison with healthy periodontum group; however, the differences were not statistically significant, whereas TAOC was lower in PD group. In the GDM arm of eight articles, two were included: one for CRP and one for adiponectin and leptin, which was insufficient for further analysis. The evidence for differences in the concentrations of inflammatory markers in pregnant women with PD and with healthy periodontum is limited, mainly due to confounding factors such as varying PD diagnostic criteria and methodology of assessing cytokine levels. However, these results may suggest a particular trend toward an attenuated inflammatory response in pregnant periodontal patients. There still exists a paucity of data on the subject.
The active form of Helicobacter pylori vacuolating cytotoxin induces decay‐accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa
Authors: Kaneko Kazuyo , Zaitoun Abed M , Letley Darren P , Rhead Joanne L , Torres Javier , Spendlove Ian , Atherton John C , Robinson Karen 
Published: July 2022

AbstractHigh‐level expression of decay‐accelerating factor, CD55, has previously been found in human gastric cancer (GC) and intestinal metaplasia (IM) tissues. Therapeutic effects of CD55 inhibition in cancer have been reported. However, the role of Helicobacter pylori infection and virulence factors in the induction of CD55 and its association with histological changes of the human gastric mucosa remain incompletely understood. We hypothesised that CD55 would be increased during infection with more virulent strains of H. pylori, and with more marked gastric mucosal pathology. RT‐qPCR and immunohistochemical analyses of gastric biopsy samples from 42 H. pylori‐infected and 42 uninfected patients revealed that CD55 mRNA and protein were significantly higher in the gastric antrum of H. pylori‐infected patients, and this was associated with the presence of IM, but not atrophy, or inflammation. Increased gastric CD55 and IM were both linked with colonisation by vacA i1‐type strains independently of cagA status, and in vitro studies using isogenic mutants of vacA confirmed the ability of VacA to induce CD55 and sCD55 in gastric epithelial cell lines. siRNA experiments to investigate the function of H. pylori‐induced CD55 showed that CD55 knockdown in gastric epithelial cells partially reduced IL‐8 secretion in response to H. pylori, but this was not due to modulation of bacterial adhesion or cytotoxicity. Finally, plasma samples taken from the same patients were analysed for the soluble form of CD55 (sCD55) by ELISA. sCD55 levels were not influenced by IM and did not correlate with gastric CD55 mRNA levels. These results suggest a new link between active vacA i1‐type H. pylori, IM, and CD55, and identify CD55 as a molecule of potential interest in the management of IM as well as GC treatment. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Sexual health and intimacy after cancer treatment in women of color: A systematic review
Authors: Arthur Elizabeth K. , Bissram Jennifer , Rechenberg Kaitlyn , Wills Annie , Campanelli Katie , Menon Usha , Nolan Timiya S. 
Published: July 2022

AbstractObjectiveCancer diagnosis and treatment can significantly affect women's sexual health and intimacy, leading to diminished quality of life in survivorship. The perspectives and experiences of women of color (WOC) with cancer are critical to inform comprehensive, inclusive sexual wellbeing care in survivorship. The purpose of this systematic review is to summarize contemporary literature describing sexual wellbeing experiences of WOC treated for cancer.MethodsA comprehensive search of CINAHL, PubMed, Embase and PsycInfo and Scopus identified studies that addressed sex and intimacy of U.S. WOC treated for cancer published in the last 15 years. The authors identified emergent themes from the literature through thematic content analysis.ResultsEighteen studies (10 qualitative, 8 quantitative) met the inclusion criteria, all with breast or gynecologic cancer samples. Studies include African American (13), Asian American (3), and Latina (10) women, as well as Non‐Hispanic Whites and ‘other’ race/ethnicity women. Overarching themes identified were: 1) impacts of treatment on sexual health and body image, 2) process of accepting and overcoming, 3) value of an engaged and supportive partner, and 4) current clinical practice and barriers to sexual health care.ConclusionsWOC experience changes in sex and intimacy after cancer treatment, and experiences of sexual function, sexual communication, and sexual healthcare are often shaped by sociocultural experiences. An understanding of WOC's sexual health and intimacy after cancer treatment can inform inclusive, culturally responsive sexual health interventions.
Population pharmacokinetic analysis of etrolizumab in patients with moderately‐to‐severely active ulcerative colitis
Authors: Moein Anita , Lu Tong , Jönsson Siv , Ribbing Jakob , Kassir Nastya , Zhang Wenhui , Sperinde Gizette , Zhang Rong , Tang Meina , Oh Young S. , Bruno Rene , Zhu Rui 
Published: July 2022

AbstractEtrolizumab is an IgG1‐humanized monoclonal antibody that specifically targets the β7 subunit of α4β7 and α4Eβ7 integrins, and it has been evaluated for the treatment of moderately‐to‐severely active ulcerative colitis (UC). Population pharmacokinetic (PK) analysis was performed to characterize etrolizumab PK properties in patients with moderately‐to‐severely active UC and evaluate covariate impacts on exposure. The population PK model was developed based on etrolizumab serum concentrations from patients with moderately‐to‐severely active UC enrolled in six studies (one phase I, one phase II, and four phase III) and validated using another phase III clinical trial. Stepwise covariate modeling was used to evaluate the impact of 23 prespecified covariates. Etrolizumab PK was best described by a two‐compartment model with first‐order absorption, with clearance decreasing over time. Population typical values were 0.260 L/day for clearance (CL) during the first dosing internal, 2.61 L for central volume, 71.2% for bioavailability, and 0.193/day for absorption rate. CL reduced over the study duration, the typical maximum reduction was 26% with an onset half‐life of 4.8 weeks. Consequently, the predicted mean terminal half‐life was shorter after a single dose (13.0 days) compared to that at steady‐state (17.1 days). Baseline body weight and albumin were the most impactful covariates for etrolizumab exposure. Final population PK model well characterized the PK properties of etrolizumab in patients with moderately‐to‐severely active UC and identified influential covariate effects.
Sustainable development, disclosure to stakeholders and the Sustainable Development Goals: Evidence from Brazilian banks' non‐financial reports
Authors: Chagas Ederson Jorge Melo das , Albuquerque José de Lima , Maia Filho Luiz Flávio Arreguy , Ceolin Alessandra Carla 
Published: July 2022

AbstractThe UN Sustainable Development Goals (SDGs) are ambitious global targets proposed by 2030 Agenda. The private sector should contribute to these goals, and the non‐financial disclosure reports is the primary means to inform stakeholders about the impacts of corporate activities on the environment and society, as well as their contributions to sustainable development. Therefore, measuring the quality of these reports is an essential task in order to propose improvements and identify the level of transparency. This article analyses 11 non‐financial reports of the largest banks operating in Brazil, using a methodological approach divided into two stages: the sustainability disclosure matrix and the measurement system. The first stage is based on the analysis of the material topics provided for in the reports under the Global Reporting Initiative standard and their relationship with the SDGs. The second stage quantitatively measures the different degrees of quality of the information disclosed for each disclosure topic, generating the disclosure quality performance indicator. This indicator allows indicating how pro sustainability a corporation is. The work contributes by proposing a quality classification of the non‐financial report, besides revealing the direct relationship existing between the number of material topics reported and the quality indicator. The main result of the empirical analysis is that Brazilian banks' reports are of low quality. Some practical implications: it was found that the more information disclosed, the better the quality of reporting; and the use of integrated reporting as a tool for disclosure of non‐financial results is suggested.
Toward an Embedded, Integrated, and Collaborative Approach to SDG Localization in African Cities
Authors: Croese Sylvia 
Published: July 2022

AbstractThe African continent represents the key hub in the global transition to a predominantly urban world. Hence, the fate of African cities—and the global South more generally—will have major implications for the extent to which the world will be able to achieve globally agreed development goals, such as the Sustainable Development Goals (SDGs). Questions about what makes for effective take-up of the SDGs lie at the heart of this book’s aim and contribution. A key term in this regard is that of “localization.” This chapter makes a case for an approach to SDG localization that is embedded in the continent’s diverse local contexts. As an introduction to the book, this chapter departs from integrated perspectives and collaborative methodologies and outlines the ways in which the book’s chapters illustrate the need for advancing such an approach in African cities.
Holographic duals of M5-branes on an irregularly punctured sphere
Authors: Couzens Christopher , Kim Hyojoong , Kim Nakwoo , Lee Yein 
Published: July 2022

Abstract
We provide explicit holographic duals of M5-branes wrapped on a sphere with one irregular puncture and one regular puncture of arbitrary type. The solutions generalise the solutions corresponding to M5-branes wrapped on a disc recently constructed by Bah-Bonetti-Minasian-Nardoni by allowing for a general choice of regular puncture. We show that the central charges, flavour central charges and conformal dimensions of BPS operators match with a class of Argyres-Douglas theory.
Nonlocality of quantum matter corrections and cosmological constant running
Authors: Gorbar E. V. , Shapiro Ilya L. 
Published: July 2022

Abstract
Semiclassical loop corrections to the gravitational action include various terms with zero, two, and four derivatives of the metric as well as nonlocal form factors for these terms. Contributions to some of these terms could be confused with others on a specific metric background or for a particular gauge fixing. We present a critical analysis of the recent works where the tensor structure and the number of derivatives in the action of gravity were not properly taken into account. Taking these relevant aspects into account, we show that although some contributions owing to the quantum fluctuations of massive or massless scalar as well as fermion and vector fields may be attributed to the “running” of the cosmological constant, in reality they correspond to the fourth derivative terms of the action.
Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice
Authors: Bertin Eléonore , Martinez Audrey , Fayoux Anne , Carvalho Kevin , Carracedo Sara , Fernagut Pierre-Olivier , Koch-Nolte Friedrich , Blum David , Bertrand Sandrine S. , Boué-Grabot Eric 
Published: July 2022

AbstractAmyotrophic lateral sclerosis (ALS) is a fatal motoneuron (MN) disease characterized by protein misfolding and aggregation leading to cellular degeneration. So far neither biomarker, nor effective treatment has been found. ATP signaling and P2X4 receptors (P2X4) are upregulated in various neurodegenerative diseases. Here we show that several ALS-related misfolded proteins including mutants of SOD1 or TDP-43 lead to a significant increase in surface P2X4 receptor density and function in vitro. In addition, we demonstrate in the spinal the cord of SOD1-G93A (SOD1) mice that misfolded SOD1-G93A proteins directly interact with endocytic adaptor protein-2 (AP2); thus, acting as negative competitors for the interaction between AP2 and P2X4, impairing constitutive P2X4 endocytosis. The higher P2X4 surface density was particularly observed in peripheral macrophages of SOD1 mice before the onset and during the progression of ALS symptoms positioning P2X4 as a potential early biomarker for ALS. P2X4 expression was also upregulated in spinal microglia of SOD1 mice during ALS and affect microglial inflammatory responses. Importantly, we report using double transgenic SOD1 mice expressing internalization-defective P2X4mCherryIN knock-in gene or invalidated for the P2X4 gene that P2X4 is instrumental for motor symptoms, ALS progression and survival. This study highlights the role of P2X4 in the pathophysiology of ALS and thus its potential for the development of biomarkers and treatments. We also decipher the molecular mechanism by which misfolded proteins related to ALS impact P2X4 trafficking at early pathological stage in cells expressing-P2X4.
Periodic homogenization in the context of structured deformations
Authors: Amar Micol , Matias José , Morandotti Marco , Zappale Elvira 
Published: July 2022

AbstractAn energy for first-order structured deformations in the context of periodic homogenization is obtained. This energy, defined in principle by relaxation of an initial energy of integral-type featuring contributions of bulk and interfacial terms, is proved to possess an integral representation in terms of relaxed bulk and interfacial energy densities. These energy densities, in turn, are obtained via asymptotic cell formulae defined by suitably averaging, over larger and larger cubes, the bulk and surface contributions of the initial energy. The integral representation theorem, the main result of this paper, is obtained by mixing blow-up techniques, typical in the context of structured deformations, with the averaging process underlying the theory of homogenization.
Akzeptanz und Stand der Digitalisierung in Klinik und Praxis
Authors: Borkowetz Angelika , Leitsmann Marianne , Baunacke Martin , Borgmann Hendrik , Boehm Katharina , Groeben Christer , Roigas Jan , Schneider Andreas W. , Speck Thomas , Schroeder-Printzen Immo , Zillich Susanne , Volkmer Björn , Witzsch Ulrich , Huber Johannes ,   Arbeitskreis Versorgungsforschung, Qualität und Ökonomie der Deutschen Gesellschaft für Urologie e. V.,   Arbeitskreis Informationstechnologie und Dokumentation der Deutschen Gesellschaft für Urologie e. V.
Published: July 2022

Zusammenfassung
Hintergrund
Die Digitalisierung der Patientendokumentation und die Einführung der elektronischen Patientenakte (ePA) stellen den klinischen Alltag vor große Herausforderungen.

Fragestellung
Wir untersuchten die Akzeptanz und den Stand der Digitalisierung von Patientendaten sowie die Einführung der ePA bei den deutschen Urologen.

Material und Methoden
Nach einem iterativen Entwicklungsprozess erhielten wir einen Fragebogen mit 30 Items, welcher über den Forschungsnewsletter der Deutschen Gesellschaft für Urologie e. V. versendet wurde.

Ergebnisse
Insgesamt beantworteten 80 Urologen den Fragebogen (Rücklaufquote 2 %). Digitale Plattformen wie Urotube oder Researchgate wurden von 63 % der Teilnehmer verwendet. Die komplette Einführung der digitalen Patientendokumentation erfolgte bei 72 % der ambulant Tätigen und bei 54 % der in der Klinik Tätigen (p = 0,042). 76 % der Befragten sahen den Digitalisierungsprozess als sinnvoll an. 34 % äußerten teilweise oder starke Bedenken bzgl. einer kompletten Digitalisierung der Patientendokumentation. Nur 14 % der Teilnehmer haben eine Videosprechstunde angeboten. Als Vorteile für die ePA wurden u. a. die bessere Vernetzung des Gesundheitswesens (73 %), die Verbesserung der Diagnose, der Indikations- (41 %) und der Behandlungsqualität (48 %) sowie die Vermeidung von Fehlmedikation (70 %) gesehen.

Schlussfolgerung
Die deutschen Urologen stehen der Digitalisierung der Patientendokumentation und der ePA insgesamt offen gegenüber. Insbesondere jüngere Urologen nutzen digitale Medien. Die Vorteile der Digitalisierung sind insbesondere eine Verbesserung der Behandlungsabläufe. Für eine reibungslose Einführung sind eine bereichsübergreifende Etablierung und ggf. eine Anpassung der Behandlungsprozesse notwendig.
Bourgeois contact structures: Tightness, fillability and applications
Authors: Bowden Jonathan , Gironella Fabio , Moreno Agustin 
Published: July 2022

AbstractGiven a contact structure on a manifold V together with a supporting open book decomposition, Bourgeois gave an explicit construction of a contact structure on $$V \times {\mathbb {T}}^2$$

V
×

T

2

. We prove that all such structures are universally tight in dimension 5, independent of whether the original contact manifold is itself tight or overtwisted. In arbitrary dimensions, we provide obstructions to the existence of strong symplectic fillings of Bourgeois manifolds. This gives a broad class of new examples of weakly but not strongly fillable contact 5-manifolds, as well as the first examples of weakly but not strongly fillable contact structures in all odd dimensions. These obstructions are particular instances of more general obstructions for $${\mathbb {S}}^1$$

S

1

-invariant contact manifolds. We also obtain a classification result in arbitrary dimensions, namely that the unit cotangent bundle of the n-torus has a unique symplectically aspherical strong filling up to diffeomorphism.
Clavicular hook plate for acute high-grade acromioclavicular dislocation involving Rockwood type V: clinical and radiological outcomes and complications evaluation
Authors: Liu Guoming , Hu Yanling , Ye Fagang , Huang Fuguo , Yu Tengbo 
Published: July 2022

Abstract
Background
The surgical treatment of high-grade acromioclavicular joint dislocation remains a matter of debate. Clavicular hook plate internal fixation was widely used in the treatment of acromioclavicular dislocation because of its easy-to-master surgical technique. This study aimed to evaluate outcomes using hook plate fixation for acromioclavicular dislocation.

Methods
A consecutive series of 57 patients with acute acromioclavicular joint dislocation involving Rockwood type V were treated between November 2013 and September 2019 using hook plate fixation. The functional outcomes (using the visual analogue score, Constant-Murley score, and University of California Los Angeles score), the quality of surgical reduction (using the coracoclavicular distance), and post-operative complications were assessed with about 46 months of follow-up.

Results
The mean Constant-Murley score increased from 72.6 before surgery to 87.6 at final follow-up. The mean University of California Los Angeles score was 14.1 pre-operatively and 31.6 at final follow-up. Meanwhile, the visual analogue scores were significantly reduced from 3.4 pre-operatively to 1.3 post-operatively. The coracoclavicular distance decreased from 19.4 mm pre-operatively to 10.9 mm at the last follow-up. Post-operative functional and radiological outcomes were significantly improved compared with pre-operative outcomes (P < 0.01). The overall excellent and good result was 35.1% (20/57) and 54.1% (31/57), respectively. At follow-up, the overall complication rate was 15.8% (9/57) including subacromial impingement (three patients), acromial osteolysis (three patients), reduction loss (one patient), acromioclavicular joint osteoarthritis (one patient), and calcification (one patient).

Conclusion
Hook plate fixation was a viable treatment approach, and achieved good clinical outcomes in the treatment of acute acromioclavicular dislocation involving V. But some complications of hook plate fixation should not be ignored.
Lessons from the COVID-19 pandemic: remote coaching in bariatric surgery
Authors: Musella Mario , Martines Gennaro , Berardi Giovanna , Picciariello Arcangelo , Trigiante Giuseppe , Vitiello Antonio 
Published: July 2022

Abstract
Background
The development of fast internet connection has stimulated different types of video-assisted teaching programs. However, a remote mentoring with the proctor not on site has never been reported in bariatric surgery. We described our experiences with remote telementoring for laparoscopic sleeve gastrectomy.

Methods
A qualified general surgeon at the beginning of his bariatric practice performed a series of 8 laparoscopic sleeve gastrectomies (LSG) while tutored by an experienced bariatric surgeon connected from a different city through a specific videoconferencing platform. Data on demographics at baseline, operative time, hospital stay, intraoperative early, and late complications were collected.

Results
Mean age and BMI of patients were 36.9 ± 9.6 years old and 41.8 ± 1.7 kg/m2. All procedures were carried out without conversion to open or complications. Mean operative time was 112.4 ± 21.9 min while the hospital stay was 3.5 ± 0.5 days. Operative time significantly decreased after the fourth operation.

Conclusions
Remote coaching appears to be possible and safe for LSG.