bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and microstructures of the GFRP waste powder/GGBS-based geopolymer paste and concrete
Authors: Zheng Chuji , Wang Jun , Liu Hengjuan , GangaRao Hota , Liang Ruifeng 
Published: March 2022

Abstract
A novel method is developed for reusing the waste glass fiber-reinforced polymer (GFRP) powder as a precursor in geopolymer production. Several activation parameters that affect the workability and strength gain of GFRP powder-based geopolymers are investigated. The results of an experimental study reveal that the early strength of GFRP powder-based geopolymer pastes develops slowly at ambient temperature. The highest compressive strength of GFRP powder-based geopolymer pastes is 7.13 MPa at an age of 28 days. The ratio of compressive strength to flexural strength of GFRP powder-based-geopolymers is lower than that of fly ash and ground granulated blast furnace slag (GGBS)-based geopolymers, indicating that the incorporation of GFRP powder can improve the geopolymer brittleness. GGBS is incorporated into geopolymer blends to accelerate the early activity of GFRP powder. The binary geopolymer pastes exhibit shorter setting times and higher mechanical strength values than those of single GFRP powder geopolymer pastes. The GGBS geopolymer concrete mixture with 30 wt% GFRP powder displayed the highest compressive strength and flexural strength values and was less brittle. The developed binary GFRP powder/GGBS-based geopolymers reduce the disadvantages of single GFRP powder or GGBS geopolymers, and thus, offer high potential as a building construction material.
A new acylated flavone glycoside, in vitro antioxidant and antimicrobial activities from Saudi Diospyros mespiliformis Hochst. ex A. DC (Ebenaceae) leaves
Authors: Hawas Usama W. , El-Ansari Mohamed A. , El-Hagrassi Ali M. 
Published: March 2022

Abstract
Phytochemical investigation of Diospyros mespiliformis leaves resulted in the isolation of new acylated flavone isoscutellarein 7-O-(4′′′-O-acetyl)-β-allopyranosyl(1′′′ → 2′′)-β-glucopyranoside (1), along with eight known flavonoid metabolites, luteolin 3′,4′,6,8-tetramethyl ether (2), luteolin 4′-O-β-neohesperidoside (3), luteolin 7-O-β-glucoside (4), luteolin (5), quercetin (6), quercetin 3-O-β-glucoside (7), quercetin 3-O-α-rhamnoside (8), and rutin (9). Their structures were identified by analysis of spectroscopic (UV, NMR, and MS) data, as well as by acid hydrolysis for the isolated glycosides. The antioxidant activity of D. mespiliformis metabolites was determined by the DPPH radical-scavenging assay. The new acylated flavone (1) and flavonol O-rhamnoside (8) displayed the highest antioxidant activities with IC50 values 15.46 and 12.32 μg/mL, respectively, with respect to the antioxidant ascorbic acid (IC50 value 10.62 μg/mL). In addition, the isolated flavonoids were evaluated against four human pathogenic bacteria where the methylated flavone (2) exhibited potent activity against Escherichia coli with inhibition zone 34 mm, and mild activity of flavonol O-rhamnoside (8) against Staphylococcus aureus with MIC value 9.77 μg/mL. According to the MBC/MIC ratio, the antibacterial activity of the isolated flavonoids was considered flavonoid 2 is bactericidal nature against S. aureus, and flavonoids 3 and 4 are bactericidal against E. coli.
Ready, communicators: Communications and public relations in the Metaverse
Authors: Chen Rita 
Published: March 2022

With the emergence of the COVID-19 pandemic and the resurgence of the Black Lives Matter movement, Canadians are consuming more media than ever. While this development has allowed us to become more informed about the important issues surrounding us, it does mean we need to give critical thought to how we are perusing different media forms and content. This editorial shares three methods that communicators can consider employing to help avoid unconscious bias when consuming media. The editorial also introduces the five articles being featured in this issue, before closing with acknowledgement and thanks to all the people who made this publication possible.
Keywords: media, unconscious bias, strategy, communication tactics
A Brief Review on the Effects of the Squat Exercise on Lower-Limb Muscle Hypertrophy
Authors: Ribeiro Alex S. , Santos Erick D. , Nunes João Pedro , Nascimento Matheus A. , Graça Ágatha , Bezerra Ewertton S. , Mayhew Jerry L. 
Published: March 2022

ABSTRACT
The squat is one of the most widely used exercises in resistance training programs. The aim of this narrative review was to analyze the effect of the squat on lower-limb muscle hypertrophy. Briefly, the available literature indicates that the squat is an effective exercise for inducing hypertrophy of the quadriceps, mainly the vastii, but also the rectus femoris, although to a reduced magnitude. Multiple lines of evidence suggest little to no hamstring hypertrophy from the back squat. Although the gluteus maximus clearly participates mechanically in the back squat, few longitudinal studies exist on the topic. The limited evidence available on this topic suggests deeper squats may be more hypertrophic for the gluteus maximus, and that, squat depth beyond 90° of knee flexion may not provide further hypertrophy of the knee extensors. Despite the popularity of the many squat variations, there are still controversies surrounding their hypertrophic potential for lower-limb musculature. Further studies are needed to investigate the hypertrophic effects of different squat variations, as well as differences in hypertrophy because of squat depth, stance, barbell position, and different squat apparatuses/machines.
Dogmatika, Filsafat Hukum Islam dan Hak Asasi Manusia: Sketsa Agenda Rekonstrran dan Penafsiran Hukum Islam
Authors: Muslimin JM 
Published: March 2022

In its formative years, Islamic law develops gradually. Along its development as a concept of reasoning as well as judging, Islamic law is a result of mixed and blended elements: a transcendental and local elements are formulated to be a coherent reference of logics. The article proposes the continuation of the blended tradition. The basic assumption is as long as sharia is able to maintain its adaptability to the newest cultural innovation and create ‘creative dialectics’ as it is shown in its glorious history of human civilization, it will survive as a moral guidelines and legal frame of thought. The article tries further to offer a model of such a creativity, especially with regard to the concept of human rights.
Conflicto sociopolítico, minería, impacto ambiental, comunidades
Authors: Monsalve Friedman Luz Marina 
Published: March 2022

Algunas de las causas del conflicto sociopolítico en Colombia se asocian a las condiciones de desplazamiento forzado y muertes violentas por la presencia de proyectos mineros, hay impactos ambientales en los ecosistemas, cambios en la dinámica territorial y las comunidades quedan afectadas por los efectos del conflicto.
Los diferentes grupos armados se disputan el territorio para poder negociar un pago por permitir la operación del proyecto, esta situación es reconocida en distintas zonas del país con presencia minera, es una condición con la que conviven las comunidades en zonas mineras, las muertes por líderes ambientales se incluyen en estos conflictos y se relacionan a la defensa de los bienes comunes donde los líderes terminan por ser víctimas del conflicto minero ambiental.
Fossil Fuel Fiction and the Geologies of Race
Authors: Tanaka Shouhei 
Published: March 2022

AbstractThis essay argues for an energy literary criticism that centers the problem of the energy epoch as the problem of the color line. It does so by reading a set of novels—Helena María Viramontes'sUnder the Feet of Jesus(1995) and Colson Whitehead'sZone One(2011) andThe Underground Railroad(2016)—as fossil fuel fictions that illuminate the conjuncture of energy and racial capitalism. These works unearth the racialized world making of extractive energy regimes by articulating energy's social production of race across the colonial histories and geographies of the Anthropocene. The entanglement of racialized bodies and hydrocarbon matter across biological, historical, and geological time scales in these novels formalizes what Kathryn Yusoff calls the “geologies of race.” Excavating the racial infrastructures scaffolding the Anthropocene's power grids, Viramontes's and Whitehead's georacial imaginations envision decolonial and abolitionist energy futures for Brown and Black lives.
Waiting for Godotand the Racial Theater of the Absurd
Authors: Vogel Shane 
Published: March 2022

AbstractThis essay argues that the 1957 Black-cast revival of Samuel Beckett'sWaiting for Godotstages an Africana absurd sensibility that precedes and supersedes European philosophies of absurdism. While the Continental absurd developed as a repudiation of Western reason and aspired to a universalizing assessment of the human condition, the Africana absurd is situated in the historical formation of racial slavery and colonialism. More specifically, the Africana absurd is a response to the formal meaninglessness and incoherencies of Western racial logic. Locating it within the existential and historical situation of Black theater in the Jim Crow era and attending to theatrical elements such as casting, stage props, and choreography, this essay shows how the production recasts Beckett's absurdism, metatheatricality, and antihumanism to present, rather than represent, the felt absurdity of racial modernity.
Similarities and Differences of International Practices and Procedures for the Regulation for Active Substance Master Files/Drug Master Files of Human Use: Moving Toward Regulatory Convergence
Authors: Matsuhama Maki , Takishita Tomoko , Kuribayashi Ryosuke , Takagi Kazunori , Wakao Rika , Mikami Kenichi 
Published: March 2022

Purpose. A gap analysis survey of international practices for Active Substance Master Files (ASMFs)/Drug Master Files (DMFs) of human use was conducted as a project of the ASMF/DMF working group of the International Generic Drug Regulators Pilot (IGDRP) to identify similarities and differences among ASMF/DMF procedures of 10 IGDRP members and 2 observers. Methods. We conducted a questionnaire survey and compared the following aspects: overall ASMF/DMF procedures, submission requirements for ASMFs/DMFs, assessment processes for ASMFs/DMFs, the technical requirements for active pharmaceutical ingredients (APIs), generation of assessment reports for ASMFs/DMFs, procedures for changing ASMF/DMF details, and Good Manufacturing Practice (GMP) inspection/certification of API manufacturers. Twelve organizations participated in this project: the Brazilian Health Surveillance Agency (Anvisa), the European Union (EU), Health Canada (HC), the Singapore Health Sciences Authority (HSA), the South African Medicines Control Council (MCC), the South Korean Ministry of Food and Drug Safety (MFDS), the Japanese Pharmaceuticals and Medical Devices Agency (PMDA), the Swiss Agency for Therapeutic Products (Swissmedic), the Taiwan Food and Drug Administration (TFDA), the Australian Therapeutic Goods Administration (TGA), the European Directorate for the Quality of Medicines & HealthCare (EDQM) (Observer) and the Prequalification Team (PQT) of the World Health Organization (WHO), which includes the PQT–Medicines (Observer). Results. Although there were many similarities among the participating agencies surveyed, there were also differences that should be discussed such as assessment processes of ASMFs/DMFs and Technical requirements for APIs. Conclusions. These differences revealed by this survey will be key considerations in order to facilitate the filing of ASMFs/DMFs globally and to establish a framework for sharing and utilizing information related to ASMFs/DMFs among IGDRP members in the future. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
PENGARUH MOTIVASI MENGHINDARI RIBA DAN PENGETAHUAN PRODUK KOPERASI SYARIAH TERHADAP KEPUTUSAN MENJADI NASABAH DI KOPERASI SIMPAN PINJAM PEMBIAYAAN SYARIAH (KSPPS) NUR HAYYU AMBARA NTB
Authors: Utomo Danang Prio , Jailani Huzain , Cahyati Regita Ayu 
Published: March 2022

This study aims to analyze partially and simultaneously the effect of the motivation to avoid usury and knowledge of sharia cooperative products on the decision to become a customer in the Sharia Savings and Loans Payment Cooperative Nur Hayyu Ambara NTB. This study uses quantitative methods. The sampling technique is Non Probability Sampling with Incidental Sampling sampling technique. The number of respondents in this study were 60 respondents. Data collection using a questionnaire and then processed using SPSS 16. Data analysis techniques using validity test, reliability test, classical assumption test, multiple linear regression test, partial test (t test), simultaneous test (f test), and coefficient of determination test (R2). The results of this study indicate that partially the motivation to avoid usury has no significant effect on the decision to become a customer of the Sharia Savings and Loans Payment Cooperative Nur Hayyu Ambara, The results of the coefficient of determination (R2) show that the influence of motivation to avoid usury and product knowledge on the decision to become a customer of the Sharia Savings and Loans Payment Cooperative Nur Hayyu Ambara NTB is 31.1% while the remaining 69.9% is influenced by factors outside the model
A PANEL DATA ANALYSIS OF FACTORS PUSHING GDP OF MALAYSIA: A RESEARCH ON SELECTED ECONOMIC INDICATORS
Authors: Chopra Monika 
Published: March 2022

Introduction: From time immemorial, the policy emphasis has always been on Gross Domestic Product (GDP) since it is the measure of wellbeing. Every country's budget is intended to move the economy in the right direction by promoting economic development.
Objective: The study is performed to analyse the long-term impact of select economic indicators from available literature review on economic growth of Malaysia.
Methodology: For meeting the research objective a panel data is famed through data collection from official website of world bank. After collecting data of selected indicators, research tools namely- mean, standard deviation, ANOVA and regression are applied.
Value: The study will lead to an understanding of which important element affects GDP and allows the policymakers to focus their attention on factors relevant to the goal of raising GDP.
THE RISK FACTORS OF HYPERTENSION IN INDONESIA (DATA STUDY OF INDONESIAN FAMILY LIFE SURVEY 5)
Authors: Khasanah Dewi Nur 
Published: March 2022

ABSTRACTBackground: Hypertension is a worrying disease, as it often does not cause symptoms. According to WHO, this disease affects 22% of the world's population, while hypertension has affected 25% of the population in Southeast Asia. In Indonesia, the prevalence of hypertensive disease increases from year to year. The suspected risk factors for hypertension are gender, age, genetics, smoking obesity, physical activity, and stress. Purpose: analyze factors that affect the prevalence of hypertension in Indonesia based on Indonesian Family Life Survey (IFLS) 5 data. Method: this study uses secondary data from Indonesia Family Life Survey (IFLS) 5 with a type of analytical observational research with cross sectional design. There were 4790 respondents who sampled research from 34,239 population. The analysis used is bivariate and multivariate. Results: bivariate analysis using chi-square test obtained factors related to hypertension incidence is gender (p=0,000), age (p=0.000), employment status (p=0.003), physical activity (p=0.011); and obesity (p=0.000). While through the test of logistic regression factors that affect hypertension is gender (p=0,000), age(p=0.000), physical activity(p=0.015), and obesity(p=0.000). Conclusion: factors that affect the incidence of hypertension are gender, age, physical activity, and obesity. ABSTRAK Latar Belakang: Hipertensi merupakan penyakit yang menghawatirkan, karena penyakit ini sering tidak menimbulkan gejala. Menurut WHO penyakit ini menyerang 22% penduduk di seluruh dunia, sedangkan penyakit hipertensi telah menyerang 25% penduduk wilayah Asia Tenggara. Di Indonesia, prevalensi penyakit hipertensi meningkat dari tahun ke tahun. Adapun yang diduga menjadi faktor risiko hipertensi yaitu jenis kelamin, umur, genetik, obesitas merokok, aktifitas fisik, dan stress. Tujuan: menganalisis faktor yang mempengaruhi kejadian hipertensi di Indonesia berdasarkan data Indonesian Family Life Survey (IFLS) 5. Metode: penelitian ini menggunakan data sekunder dari Indonesia Family Life Survey (IFLS) 5 dengan jenis penelitian observasional analitik dengan desain cross sectional. Terdapat 4790 responden yang menjadi sampel penelitian dari 34.239 populasi. Analisis yang digunakan adalah bivariat dan multivariat. Hasil: analisis bivariat yang menggunakan uji chi-square didapatkan faktor yang berhubungan dengan kejadian hipertensi adalah jenis kelamin (p=0,000); umur (p=0,000); status pekerjaan (p=0,003); aktifitas fisik (p=0,011); dan obesitas (p=0,000). Sedangkan melalui uji regresi logistik faktor yang berpengaruh terhadap hipertensi adalah jenis kelamin (p=0,000), umur (p=0,000), aktifitas fisik (p=0,015), dan obesitas(p=0,000). Kesimpulan: faktor yang berpengaruh terhadap kejadian hipertensi adalah jenis kelamin, umur, aktifitas fisik, dan obesitas.
Relationship between the transcriptional activity of СT-genes and survival in colorectal cancer patients
Authors: Kutilin D. S. , Kit O. I. 
Published: March 2022

Introduction. High incidence and mortality rates of colorectal cancer indicate an urgent need for the use of new highly specific diagnostic and prognostic molecular markers. In this aspect, cancer testis antigens (CTA s) are of particular interest.The aim of the study was to analyze the relationship between the transcriptional activity of CTA s and survival in colorectal cancer patients with metastases (T1–4N1–2M1–2) and without metastases (T1–3N0M0).Results. The relative expression of 16 genetic loci (MAGE-A1, MAGE-A2, MAGE-A3, MAGE-A4, MAGE-B1, MAGE-B2, GAGE-1, GAGE-3, GAGE-4, MAGE-C1, BAGE, XAGE3, NYESO1, SSX2, SCP1 and PRAME1) was determined by real-time PC R. In colorectal cancer patients having no metastases, the expression of SSX2 and PRAME1 genes was significantly higher and the expression of BAGE was significantly lower in colon tumor tissue than in normal tissue (p<0.05). In colorectal cancer patient with metastases, the expression of GAGE1, SCP1 and PRAME1 genes was significantly higher and the expression of MAGEA2, MAGEB1, MAGEB2, GAGE4 and NY-ESO1 genes was significantly lower in colon tumor tissue than in normal tissue (p<0.05). The expression of the GAGE1, BAGE, SSX2, MAGEA2, SCP1 and MAGEB1 genes was found to have a significant impact on the overall survival and the development of distant metastasis (p<0.05).Conclusion. The data obtained are the basis for the formation of a panel of effective immunotherapeutic targets and prognostic markers for colorectal cancer patients with and without metastases.
Mutational profile of KRAS-positive colorectal cancer
Authors: Telysheva E. N. , Shaikhaev E. G. , Snigireva G. P. 
Published: March 2022

Aim: to study the features of the molecular genetic profile of KRAS-positive colorectal cancer (CRC).Material and Methods. The study included 42 patients diagnosed with colorectal cancer. The KRAS gene mutation was detected in tumor tissue of these patients by real-time PC R. Using the next generation sequencing technology (NGS ) on the Illumina platform, the genes involved in the molecular pathogenesis of colorectal cancer, namely KRAS, BRAF, NRAS, APC, TP53, SMAD2, SMAD4, FBXW7, PIK3CA, CTNNB1, TCF7L2, MLH1, MSH2, MSH3, MSH6, ATM, TGF-BR2, AKT1, CDC27, CASP8, MAP2K4, DCC, DMD, MAP7, ERBB2, P3H3, MIER3, CADM1, FLT4, PTPN12, PIK3R1, and EP300 were analyzed. Sample preparation of libraries from isolated DNA was carried out using commercial kits GeneRead DNAS eq Targeted Panel v2 Human Colorectal Cancer (Qiagen, USA ); NEBNext Ultra DNA library Prep kit for Illumina and NEBNext Multiplex Oligos for Illumina (New England BioLabs).Results. In 36 patients with KRAS-positive tumors, changes were observed in 13 genes involved in the molecular pathogenesis of colorectal cancer. A total of 82 somatic variants were identified. Moreover, 9 patients additionally had one mutation each, 17 patients had 2 mutations each, 7 patients had 3 mutations each, and 3 patients had 4 mutations each. Combination of three mutations in key genes involved in the pathogenesis of colorectal cancer (KRAS, APC и TP53) was detected in 15 (36 %) patients. Combination of two mutations in the KRAS and APC genes was detected in 10 (23.8 %) patients, and in the KRAS and TP53 genes – in 8 (19.1 %) patients. The largest number of somatic mutations was found in the APC (59.5 %) and TP53 (54.7 %) genes. It was hown that a combination of three mutations in key genes was the most unfavorable prognosis factor and indicated a higher aggressiveness of the tumor process.Conclusion. The information obtained using the NGS method on the mutational status of a KRAS -positive tumor in patients with colorectal cancer allows for personalized treatment as well as predicting the outcome.
Wprowadzenie zastępczych (substytutów) rodziców chrzestnych przez Konferencję Episkopatu Polski a możliwe sytuacje analogiczne poza przypadkami przysposobienia
Authors: Trojanowski Bartosz 
Published: March 2022

W wielu przypadkach praktyki duszpasterskiej pojawiają się sytuacje, w których rodzice chrzestni nie mogą, nie chcą pełnić swojego zadania lub nie zostali wyznaczeni przez rodziców lub prawnych opiekunów. W konsekwencji tego dziecko, a nawet dorosły w najbliższym czasie od chrztu nie może otrzymać „pomocy duchowej”, którą powinien być rodzic chrzestny wobec swojego chrześniaka.
W przypadku zadania chrzestnego można mówić o pewnego rodzaju analogii do urzędu kościelnego, a w konsekwencji można również stwierdzić istnienie „wakatu” zadania chrzestnego w przypadkach, kiedy nie ma nikogo, kto byłby powołany do udzielenia tej „duchowej pomocy” rodzicom lub prawnym opiekunom.
W rezultacie można mówić o pewnego rodzaju luce prawnej, ponieważ prawo powszechne nie podaje wprost rozwiązania tej kwestii prawnej. Pośrednio jednak można upatrywać rozwiązanie takiej sytuacji w możliwości wyznaczenia świadka bierzmowania, który nie jest chrzestnym. Jednakże to rozwiązanie, zawarte w prawie powszechnym, jest możliwe jedynie w momencie przystępowania do sakramentu bierzmowania. Dlatego można mówić dalej o luce prawnej, ponieważ są inne przypadki, w których ustanowienie zastępczej „pomocy duchowej” świadczonej przez tych, którzy pełnią zadanie rodziców chrzestnych, jest jak najbardziej wskazane. Dlatego w rozwiązaniu tej kwestii należy przywołać prawo partykularne obowiązujące w Polsce, które stosuje się w przypadkach przysposobienia