bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracing southern Gondwanan sedimentary paths: A case study of northern Namibian late Palaeozoic sedimentary rocks
Authors: Zieger Johannes , Hofmann Mandy , Gärtner Andreas , Gerdes Axel , Marko Linda , Linnemann Ulf 
Published: January 2022

AbstractThe northern Namibian Karoo‐aged successions are part of a Gondwana‐wide sedimentary system emerging at the Carboniferous–Permian boundary and existing for more than 50 Ma. The Karoo Supergroup sedimentary successions are of importance in understanding the evolution of the Karoo rift system. This study presents new whole‐rock geochemical data combined with detrital zircon morphology as well as U−Pb ages and Lu−Hf composition of late Palaeozoic siliciclastic rocks of the Namibian Huab Basin and Kunene area (south‐west Africa). Inferred by youngest detrital zircon U−Pb ages the Verbrande Berg Formation (lower Ecca Group) yields a Sakmarian to Asselian maximum depositional age, whereas the overlying Tsarabis Formation yields an Artinskian maximum depositional age. These ages coincide with the end of the Dwyka ice age and an overall warming and a contemporaneous evolution of the Karoo I rift system across southern Gondwana. The zircon age distribution of the investigated samples yields clusters ranging between ca 500 to 650 Ma (Cambrian–late Neoproterozoic), ca 950 to 1200 Ma (early Neoproterozoic–Mesoproterozoic) and ca 1800 to 1900 Ma (Palaeoproterozoic). Their rounded shapes characterize the zircon grains of the Kunene area and the lower Huab Basin section, whereas upper Huab Basin strata yield mostly unrounded grains. The rounded nature of zircon grains with a diverse U−Pb age spectrum putatively points towards sediment homogenization and multiple recycling stages during the deposition of the sediments and large catchment areas of the depositing rivers. As suggested by zircon grains with a low roundness value and a single Palaeoproterozoic age cluster, the upper Huab Basin successions were probably deposited under drier climatic conditions, small catchment areas and limited sedimentary homogenization. Therefore, the southern Gondwana sedimentary transport and homogenization system may change over time and is dependent on the climate prevailing during deposition. This study shows that the laws of detrital zircon are very complex and are yet to be explored.
Utilization of multi‐scale geomorphometric algorithms and third‐order morphometric variables for soil thickness modeling
Authors: Khanifar Javad , Khademalrasoul Ataallah 
Published: January 2022

AbstractThe significance of multi‐scale geomorphometric algorithms and third‐order morphometric variables was studied in soil thickness modeling. In this research, the algorithms of Evans–Young, Shary, Zevenbergen–Thorne, and Florinsky were employed to calculate morphometric variables on different neighborhood scales. The results demonstrate that the polynomial model and neighborhood scale can have a remarkable effect on morphometric variables. Based on correlation analysis, we observed that on a given neighborhood scale, not every polynomial model might be appropriate for modeling soil thickness. A geomorphometric algorithm that provides a modest smoothing rate of morphometric variables can be ideal for soil–landscape modeling. The results revealed that , a third‐order morphometric variable, was the most relevant predictor of soil thickness. The third‐order morphometric variables have the potential to be considered for soil–landscape modeling. Multivariate adaptive regression splines provided a model (R2 = 0.71, RMSE = 0.28 m) for predicting soil thickness based on local morphometric variables that were calculated using two types of polynomial models. Based on the findings of this study, it is recommended that several polynomial models and neighborhood sizes be employed when performing soil–landscape analysis. Consideration of multi‐scale geomorphometric analysis can increase the performance of digital soil modeling.
Re‐irradiation of canine non‐lymphomatous nasal tumours using stereotactic radiation therapy (10 Gy x 3) for both courses: Assessment of outcome and toxicity in 11 dogs
Authors: Gieger Tracy L. , Haney Siobhan M. , Nolan Michael W. 
Published: January 2022

AbstractNo uniformly beneficial treatments exist for dogs with non‐lymphomatous nasal tumours (NLNT) that relapse after radiotherapy (RT). Reirradiation may prolong survival and improve quality of life. In this retrospective study, we describe outcomes for 11 dogs that had CT‐confirmed locoregional progression of NLNT after an initial course of stereotactic RT (SRT#1; 10 Gy × 3) and were then re‐treated with the same type of protocol (SRT#2, also 10 Gy × 3). The median time between SRT #1 and SRT #2 was 243 days (95% CI: 78–385 days). Ten dogs (91%) had a clinical benefit after SRT#1; five dogs (45%) had clinical benefit after SRT#2. Adverse events after SRT#2 included nasocutaneous or oronasal fistula formation (N = 3 at 180, 270, and 468 days), seizures (N = 2 at 78 and 330 days), bacterial or fungal rhinitis (N = 2 at 240 and 385 days), and facial swelling (N = 1 at 90 days). All 11 dogs have died, due to disease progression, presumed radiotoxicity, or declining quality of life; in most cases, it was difficult to discern between these conditions. The median overall survival time (OST) from SRT#1 was 745 days (95% CI: 360–1132). The median overall survival time (OST) from SRT #2 was 448 days (95% CI: 112–626). For these dogs, survival was prolonged, but adverse events after SRT#2 were common (8/11; 73%). Therefore, before consenting to re‐irradiation with this protocol, pet owners should be counselled about survivorship challenges, including risk for severe toxicities, and persistence of clinical signs.
Evaluating the efficacy of telephone‐based outreach in addressing hypertension control among black men with severe hypertension: An observational study
Authors: Raman Rohith Sai , Biola Holly , Bakovic Melanie , Hayes Tiffany , Whitney Colette , Bulgin Dominique , Kang Yunah , Eck Cameron , Gilchrist L’Tanya , Caesar Awanya , Chaplin Joan , Granger Bradi 
Published: January 2022

AbstractBackgroundThe high prevalence of uncontrolled hypertension (systolic blood pressure [SBP] ≥140 mmHg or diastolic blood pressure [DBP] ≥90 mmHg) in Black patients represents a significant racial health disparity in the United States.AimsThis study evaluated the efficacy of a telephone‐based strategy for inviting high‐risk patients with severe hypertension to weekly self‐management education classes. Further, the study assessed how the outreach intervention correlated with relevant quality improvement outcomes, including improved blood pressure and primary care follow‐up among our clinic population of Black men with severe hypertension.MethodsA cohort of 265 Black men aged ≥18 years with SBP ≥160 mmHg or DBP ≥100 mmHg at the most recent clinic visit were identified using Epic reports formatted for Federal Uniformed Data Set annual reporting. Telephone outreach was used to invite the cohort to attend weekly in‐person classes facilitated by various healthcare professionals. Logistic regression was performed to determine the associations between being reached by phone with (1) class attendance and (2) follow‐up appointment attendance.ResultsMost of the Black men were single (57.4%, n = 152), 49.1% had history of alcohol or substance use (n = 130), and 35.8% (n = 95) was uninsured. The average age was 55.6 years (SD = 11.6). After controlling for sociodemographic factors, being reached by phone was significantly associated with an increased likelihood of patient attendance at follow‐up appointments (OR = 1.91, p = .038) but not with class attendance (OR = 2.45, p = .155). Patients who attended a follow‐up appointment experienced significant reductions in both SBP and DBP at 9 months.Linking evidence to actionTelephone outreach was labor‐intensive but effective in keeping under‐resourced patient populations engaged in primary care. Future work should aim to develop more efficient strategies for engaging high‐risk patients in self‐monitoring education to manage hypertension.
Shrinkable Self-Similar Structure Design
Authors: Yamamoto Yohei , Mitani Jun 
Published: January 2022

Abstract
Origami techniques, as folding and unfolding, can be utilized in shrinkable structures. Especially when the crease pattern is rigid foldable, it can be treated as a mechanical linkage of rigid panels connected by hinges. Since rigid foldable crease patterns have the strong geometrical constraint of the facets not being able to stretch or bend, it is difficult to design new crease patterns, and variations of existing patterns are limited. However, it is known that there are cases where crease patterns can be made rigid foldable by adding some slits. This paper proposes a mechanical linkage that folds into a similar flat shape by adding slits. A method is presented of generating rigid foldable crease patterns in arbitrary polygons that fold smaller, and it is confirmed that structures that have a mechanism for shrinking can be generated from these crease patterns using rigid thick panels and hinges.
A Portable Six-Wheeled Mobile Robot With Reconfigurable Body and Self-Adaptable Obstacle-Climbing Mechanisms
Authors: Song Zhen , Luo Zirong , Wei Guowu , Shang Jianzhong 
Published: January 2022

Abstract
Mobile robots can replace rescuers in rescue and detection missions in complex and unstructured environments and draw the interest of many researchers. This paper presents a novel six-wheeled mobile robot with a reconfigurable body and self-adaptable obstacle-climbing mechanisms, which can reconfigure itself to three locomotion states to realize the advantages of terrain adaptability, obstacle-crossing ability, and portability. Design criteria and mechanical design of the proposed mobile robot are first presented, based on which the geometry of the robot is modeled and the geometric constraint, static conditions, and motion stability condition for obstacle crossing of the robot are derived and formulated. Numerical simulations are then conducted to verify the geometric passing capability, static passing capability, and motion stability and to find feasible structure parameters of the robot in obstacle crossing. Further, a physical prototype of the proposed mobile robot is developed and integrated with mechatronic systems and remote control. Using the prototype, field experiments are carried out to verify the feasibility of the proposed design and theoretical derivations. The results show that the proposed mobile robot satisfies all the criteria set and is feasible for applications in disastrous rescuing scenarios.
Numerical Simulations of a Freely Falling Rigid Sphere in Bounded and Unbounded Water Domains
Authors: Pandey Deepak K. , Lim Hee-Chang 
Published: January 2022

Abstract
Numerical studies were conducted on the hydrodynamics of a freely falling rigid sphere in bounded and unbounded water domains to investigate the drag coefficient, normalized velocity, pressure coefficient, and skin friction coefficient as a function of dimensionless time. The bounded domain was simulated by bringing the cylindrical water container’s wall closer to the impacting rigid sphere and linking it to the blockage ratio (BR), defined as the ratio of the projection area of a freely falling sphere to that of the cross-sectional area of the cylindrical water container. Six cases of bounded domains (BR = 1%, 25%, 45%, 55%, 65%, and 75%) were studied. However, the unbounded domain was considered with a BR of 0.01%. In addition, the k–ω shear stress transport (SST) turbulence model was used, and the computed results of the bounded domain were compared with those of other studies on unbounded domains. In the case of the bounded domain, which has a higher value of BR, a substantial reduction in normalized velocity and an increase in the drag coefficient were found. Moreover, the bounded domain yielded a significant increase in the pressure coefficient when the sphere was half-submerged; however, an insignificant effect was found on the skin friction coefficient. In the case of the unbounded domain, a significant reduction in the normalized velocity occurred with a decrease in the Reynold number (Re), whereas the drag coefficient increases with a decrease in Reynolds number.
Aging: A Theory Based on Free Radical and Radiation Chemistry
Authors: Harman Denham 
Published: January 2022

This 1956 paper describes a theory about mechanisms of aging that is based on free radical chemistry: "Aging and the degenerative diseases associated with it are attributed basically to the deleterious side attacks of free radicals on cell constituents and on the connective tissues. The free radicals probably arise largely through reactions involving molecular oxygen catalyzed in the cell by oxidative enzymes and in the connective tissues by traces of metals such as iron, cobalt, and manganese."
Copyright (c) The Gerontological Society of America. Reproduced by permission of the publisher.

Denham Harman, Aging: A Theory Based on Free Radical and Radiation Chemistry.
J. Gerontol.
11
, 298-300 (1956).
Structural disconnectome analysis of acute freezing of gait due to parietal stroke: implications for FOG pathogenesis
Authors: Ferreira Axel , Coelho Paulo Simões , Alves Pedro Nascimento , Carvalho Vanessa 
Published: January 2022

Acute onset isolated freezing of gait (FOG) is a rare and defying diagnosis. Its pathophysiology is not yet totally understood and several brain regions seem to be involved. Postlesional FOG can help to shed light on the networks involved.We report a case of an 80-year-old woman who presented to the emergency department with acute onset impairment of gait. Her medical history was unremarkable. On neurological examination she was presented with difficulties in gait initiation, turning and progressing through narrow spaces. Her remaining neurological examination was unremarkable. Brain CT showed a subacute cortico-subcortical right parieto-occipital infarction. Acute isolated FOG due to parieto-occipital stroke was diagnosed. A structural disconnectome analysis showed that the lesion disrupted structural connections with the ipsilateral ventral striatum. This case highlights that acute onset FOG might be a consequence of a parietal cortical lesion.
HIV testing behaviour and associated factors in men who have sex with men by level of urbanisation: a cross-sectional study in the Netherlands
Authors: Leenen Jeanine , Wijers Juliën N A P , Den Daas Chantal , de Wit John , Hoebe Christian J P A , Dukers-Muijrers Nicole H T M 
Published: January 2022

ObjectivesRegular HIV testing in men who have sex with men (MSM) enables timely entry into care and reduces the likelihood of HIV transmission. We aimed to assess HIV-testing behaviour and associated factors in MSM by urbanisation of place of residence.DesignData were derived from online survey (‘Men & Sexuality’) in the Netherlands, which was mainly advertised on social media (Facebook and Instagram), dating websites, apps for MSM (Grindr and PlanetRomeo) and gay media.Primary and secondary outcome measuresHIV testing was defined as recent (<1 year), not recent (≥1 year) or never. Using multinominal regression analyses, factors associated with not recent testing and never testing, compared with recent testing, were assessed among MSM living in highly (>2500 residences/km2) or non-highly (≤2500 residences/km2) urbanised areas.ParticipantsThe study sample included 3815 MSM, currently living in the Netherlands. The mean age was 36 years (SD 14.7), and 67.6% were highly educated.ResultsIn highly urbanised areas, 11.8% was never and 19.8% was not recently HIV-tested. In non-highly urbanised areas, this was 25.2% and 19.6%. Among MSM living in highly urbanised areas, independently associated with never and not recent testing were younger age, self-identification as bisexual, fewer sex partners, never notified of HIV and no recent condomless anal intercourse. Among MSM living in non-highly urbanised areas, lower perceived HIV severity, higher perceived HIV risk and a lower proportion gay friends were associated with never and not recent testing. Among never tested MSM, those in non-highly urbanised areas preferred self-sampling/self-testing over facility-based testing; those in highly urbanised areas preferred testing at healthcare facilities.ConclusionsThe proportion of never tested MSM was high (25%) in non-highly urbanised areas in the Netherlands. MSM living in non-highly urbanised areas may possibly be reached with targeted approaches to increase HIV testing uptake such as self-testing/self-sampling strategies.
Immediate acupuncture with GB34 for biliary colic: protocol for a randomised controlled neuroimaging trial
Authors: Sun Ning , He Dong-Mei , Ye Xiangyin , Bin Lei , Zhou Yuanfang , Deng Xiaodong , Qu Yuzhu , Li Zhengjie , Cheng Shirui , Shao Shuai , Zhao Feng-Juan , Zhang Tie-Huan , Cai Jing , Sun Ruirui , Liang Fan-rong 
Published: January 2022

IntroductionAs the main manifestation of gallstone disease, biliary colic (BC) is an episodic attack that brings patients severe pain in the right upper abdominal quadrant. Although acupuncture has been documented with significance to lead to pain relief, the immediate analgesia of acupuncture for BC still needs to be verified, and the underlying mechanism has yet to be covered. Therefore, this trial aims first to verify the immediate pain-alleviation characteristic of acupuncture for BC, then to explore its influence on the peripheral sensitised acupoint and central brain activity.Methods and analysisThis is a randomised controlled, paralleled clinical trial, with patients and outcome assessors blinded. Seventy-two patients with gallbladder stone disease presenting with BC will be randomised into a verum acupuncture group and the sham acupuncture group. Both groups will receive one session of immediate acupuncture treatment. Improvements in patients’ BC will be evaluated by the Numeric Rating Scale, and the pain threshold of acupoints will also be detected before and after treatment. During treatment, brain neural activity will be monitored with functional near-infrared spectroscopy (fNIRS), and the needle sensation will be rated. Clinical and fNIRS data will be analysed, respectively, to validate the acupuncture effect, and correlation analysis will be conducted to investigate the relationship between pain relief and peripheral–cerebral functional changes.Ethics and disseminationThis trial has been approved by the institutional review boards and ethics committees of the First Teaching Hospital of Chengdu University of Traditional Chinese Medicine, with the ethical approval identifier 2019 KL-029, and the institutional review boards and ethics committees of the First People’s Hospital of Longquanyi District, with the ethical approval identifier AF-KY-2020071. The results of this trial will be disseminated through peer-reviewed publications and conference abstracts or posters.Trial registration numberCTR2000034432.
Effects of diet on obesity-related anthropometric characteristics in adults: a protocol for an umbrella review of meta-analyses of randomised controlled trials
Authors: Fu Shunlian , Zhou Qian , Yuan Lijun , Li Zinan , Chen Qiu 
Published: January 2022

IntroductionThere have been many meta-analyses of randomised controlled trials on the influence of different diets on obesity-related anthropometric characteristics in adults. However, whether diet interventions can effectively decrease obesity-related anthropometric characteristics remains unclear. The objective of this study is to summarise and synthesise the evidence on the effects of diet on obesity-related anthropometric characteristics in adults by an umbrella review of meta-analyses of randomised controlled trials.Methods and analysisWe will first retrieve English articles only published before 15 December 2021 by searching PubMed, Embase and Web of Science. Only articles that are meta-analyses of randomised controlled trials will be included. Three researchers will independently screen the titles and abstracts of retrieved articles and check the data extracted from each eligible meta-analysis. In each meta-analysis, we will consider calculating the effect size of the mean difference of the effect of each diet on obesity-related anthropometric characteristics in adults using a random-effect model or a fixed-effect model according to heterogeneity. Study heterogeneity (Cochrane’s Q and I2 statistics) and small-study effects (Egger’s test or Begg’s test) will be considered. Evidence of each effect size will be graded according to the NutriGrade scoring system. We will use AMSTAR-2 (A Measurement Tool to Assess Systematic Reviews V.2) to assess the methodological quality of each meta-analysis.Ethics and disseminationThis umbrella review will provide information on the effects of different diets on obesity-related anthropometric characteristics in adults. Ethical approval is not necessary for this study. We will publish the completed umbrella review and related data online.PROSPERO registration numberCRD42021232826.
Healthcare resource utilisation for chronic kidney disease and other major non-communicable chronic diseases in China: a cross-sectional study
Authors: Yang Chao , Long Jianyan , Shi Ying , Zhou Zhiye , Wang Jinwei , Zhao Ming-Hui , Wang Haibo , Zhang Luxia , Coresh Josef 
Published: January 2022

ObjectiveTo evaluate the healthcare resource utilisation for chronic kidney disease (CKD) and other major non-communicable chronic diseases (NCDs) in China.DesignA cross-sectional study.SettingA national inpatient database of tertiary hospitals in China.ParticipantsThe study included a total of 19.5 million hospitalisations of adult patients from July 2013 to June 2014. Information on CKD and other major NCDs, including coronary heart disease (CHD), stroke, hypertension, diabetes, chronic obstructive pulmonary disease (COPD) and cancer, was extracted from the unified discharge summary form.Outcome measuresCost, length of hospital stay and in-hospital mortality.ResultsThe percentages of hospitalisations with CKD, CHD, stroke, hypertension, diabetes, COPD and cancer were 4.5%, 9.2%, 8.2%, 18.8%, 7.9%, 2.3% and 19.4%, respectively. For each major NCD, the presence of CKD was independently associated with longer hospital stay, with increased percentages ranging from 7.69% (95% CI 7.11% to 8.28%) for stroke to 21.60% (95% CI 21.09% to 22.10%) for CHD. Hospital mortality for other NCDs was also higher in the presence of CKD, with fully adjusted relative risk ranging from 1.91 (95% CI 1.82 to 1.99) for stroke to 2.65 (95% CI 2.55 to 2.75) for cancer. Compared with other NCDs, CKD was associated with the longest hospital stay (22.1% increase) and resulted in the second highest in-hospital mortality, only lower than that of cancer (relative risk, 2.23 vs 2.87, respectively).ConclusionsThe presence of diagnosed CKD alongside each major NCD was associated with an additional burden on the healthcare system. Healthcare resource utilisation and prognosis of CKD were comparable with those of other major NCDs, which highlights the importance of CKD as a major public health burden.