bluuebunny/crossref_metadata_2025_split huggingface dataset:
First report of the alien ambrosia beetle Cnestus mutilatus and further finding of Anisandrus maiche in the European part of the EPPO region (Coleoptera: Curculionidae: Scolytinae: Xyleborini)
Authors: Colombari Fernanda , Martinez‐Sañudo Isabel , Battisti Andrea 
Published: April 2022

AbstractBased on specimens collected in traps in North‐Eastern Italy, Cnestus mutilatus (Blandford, 1894), an ambrosia beetle native to Asia, is reported for the first time in Italy and in the European part of the EPPO region. A second species, Anisandrus maiche Kurentsov, 1941, is recorded for the first time in Italy and the third time in the European part of the EPPO region 14 and 12 years after the first detection in Ukraine and in European Russia, respectively. Both species are EU quarantine pests associated with the pathway of plants for planting and with wood material. Furthermore, they are polyphagous, able to reproduce on several genera of deciduous plants typical of temperate regions, and able to attack small diameter material and to colonize stressed and/or weakened plants. Surveillance based on traps and rearing from symptomatic material may help to assess the size and distribution of the beetle populations, the spread capability and to identify the most susceptible hosts.
EBPSO: Enhanced binary particle swarm optimization for cardiac disease classification with feature selection
Authors: Wadhawan Savita , Maini Raman 
Published: April 2022

AbstractCardiac disease is one of the leading causes of death worldwide, and its early detection and diagnosis can considerably increase the lifespan of patients. An automated expert system for early and accurate diagnosis that offsets human error can be designed using machine intelligence and appropriate pre‐processing of data to ensure accuracy. To that end, enhanced binary particle swarm optimization (EBPSO) has been investigated in this paper to enable the definitive classification of cardiac disease with the aid of feature selection. The primary objective of this study is to improve the accuracy of the classification and the convergence speed while employing a lesser number of features. In order to achieve this, a new adaptive inertia weight was introduced to balance the exploitation and exploration capability of binary particle swarm optimization (BPSO). In addition, a novel idea called ‘neighbourhood best’ is introduced in the velocity update equation to improve the convergence speed. The proposed EBPSO approach was tested over well‐known datasets of heart disease, that is, the Cleveland dataset, Hungarian dataset, Switzerland dataset, and Long‐Beach‐Va datasets. For classification purposes, two well‐known classifiers, k‐nearest neighbour, and support vector machine were used with the EBPSO. Furthermore, the performance of EBPSO was compared with the traditional BPSO, as well as with BPSO with proposed inertia weight (Wa‐BPSO) and other PSO variants. It has been observed that the proposed approach EBPSO with KNN shows remarkable efficiency in terms of average classification accuracy and convergence rate. The average classification accuracy for Cleveland dataset is 92.814%, for the Hungarian dataset is 91.97%, for the Switzerland dataset is 91.626% with EBPSO+KNN and for the Long‐Beach‐Va dataset is 85.253% with EBPSO + SVM. Additionally, the performance of Wa‐BPSO was compared with other commonly used inertia weights. The results of this study demonstrated that the proposed approach produces better results in terms of both the accuracy of classification as well as the convergence rate with a reduced feature set.
Telmisartan: An angiotensin receptor blocker regulates osteoclastogenesis via inhibition of the ERK triggering in osteoporotic male rats
Authors: Mahmoud Mohamed Aziz , Safar Marwa M. , Agha Azza M. , Khattab Mahmoud M. , Saleh Dalia O. 
Published: April 2022

AbstractGreat attention was recently given to the importance of RAS in controlling inflammatory bone diseases, following the discovery of its local existence in skeletal tissues. Local RAS was found to be expressed on osteoblastic and osteoclastic cells and to exert its action via angiotensin II (AngII) receptors, including angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptors. Telmisartan (TLM), an AT1R blocker (ARBs), was investigated in the present study for its therapeutic effect on bone health in osteoporotic rats. d‐Galactose, a reducing sugar at a dose of 200 mg/kg/day/i.p., was used to induce osteoporosis in male rats. TLM, at a dose of 5 mg/kg/day, was orally introduced in the osteoporotic rats for four consecutive weeks. Tibia and femur bone densitometry was estimated, bone formation and bone resorption biomarkers serum levels were measured, mineral content in blood was also valued, and finally the extracellular regulated kinase (ERK) expression in bone was determined. TLM considerably improved the deleterious effect of d‐galactose on bone mineral density. It blunted serum bone‐specific alkaline phosphatase and osteocalcin while elevating serum osteoprotegrin (OPG). On the other hand, TLM turned off the pronounced elevation in serum receptor activator of nuclear factor‐κβ ligand (RANKL), tartrate‐resistant acid phosphatase, and cathepsin K. Furthermore, it significantly hindered the bone expression of ERK which hampered osteoclastogenesis. AT1R inhibition abolished the rise in serum calcium and phosphorus and normalized serum superoxide dismutase and catalase. These TLM protective effects in d‐galactose‐treated rats were confirmed by the histopathological examination. The results all together denote the potential therapeutic value of ARBs therapy in osteoporosis.
Unified creep constraint parameter solutions for surface cracks in plates under tensile and bending loads
Authors: Wang Kai , Wang Guozhen , Tu Shantung , Xuan Fuzhen 
Published: April 2022

AbstractIn order to accurately assess creep crack initiation (CCI) and growth (CCG) life for elevated temperature cracked structures, both out‐of‐plane and in‐plane constraints need to be considered, and the unified creep constraint parameter solutions should be investigated. In this work, the new unified creep constraint parameter Ac values for plate structures with various surface crack sizes subjected to tensile and bending loads have been investigated and obtained using three‐dimensional (3D) finite element (FE) analysis. The effects of material creep properties, crack sizes, loading modes, and plate thickness on the parameter Ac have also been analyzed. The estimation equation of Ac for materials with different creep exponent n has been fitted. The parameter Ac solutions can be used in CCI and CCG life evaluation of the C*‐Ac two‐parameter approach for cracked plates subjected to tensile and bending loads.
Implications of ΔK‐Rratio in vacuum
Authors: Vasudevan Asuri K. , Kujawski Daniel 
Published: April 2022

AbstractIn this article we discuss the high vacuum implications on the role of positive load ratios (R = Pmin/Pmax) on the threshold ΔKthand fatigue crack growth (FCG) behavior in commercial alloys. It is experimentally observed that the ΔKthis independent ofRin vacuum. Also, for a given applied ΔK, FCG rate is weakly dependent ofRover the entire range of crack growth rates for several alloys. In addition, limited data on both short and long crack FCG in vacuum results fall within the same experimental scatter suggesting that a typical small crack FCG effect observed in lab air was insignificant or diminished in vacuum. A marginalR‐ratio effects on ΔKthin vacuum are seen for materials with different microstructures, yield strengths, elastic modulus, work hardening properties, and slip modes. The provided analysis and examples seem to imply that FCG in vacuum be primarily dependent on applied ΔK that comes from mechanical driving force. Possible mechanistic explanations are given.
Micro‐CT assessment of gap‐containing areas along the gutta‐percha‐sealer interface in oval‐shaped canals
Authors: De‐Deus Gustavo , Santos Gustavo O. , Monteiro Iara Zamboni , Cavalcante Daniele M. , Simões‐Carvalho Marco , Belladonna Felipe G. , Silva Emmanuel J. N. L. , Souza Erick M. , Licha Raphael , Zogheib Carla , Versiani Marco A. 
Published: April 2022

AbstractAimTo assess the interfacial adaptation (gap‐containing areas) of two root canal sealers (EndoSequence BC Sealer and AH Plus) to a conventional gutta‐percha (GP) cone (GP‐sealer interface) in oval‐shaped canals filled using the single cone technique.MethodologySixteen teeth with oval‐shaped canals were selected, scanned in a micro‐computed tomographic device, and pair‐matched according to the volume, aspect ratio and configuration of root canals. Root canals were then sequentially prepared with WaveOne Gold Primary and Large instruments, followed by filling with WaveOne Large GP points associated with either the premixed calcium‐silicate EndoSequence BC Sealer or the epoxy resin‐based AH Plus sealer (n = 8 per group) using the single cone technique. After 7 days stored in phosphate‐buffered saline solution at 37°C, the specimens were rescanned and the reconstructed images segmented in order to differentiate the filling materials (sealer and GP cone) to the dentine. A total of 453 cross‐sectional slices were assessed and categorized according to the presence or absence of gaps at the GP‐sealer interface. Mann–Whitney U‐test verified the differences between groups and were considered significant at alpha = 5%.ResultsGaps were non‐homogenously distributed in two‐dimensional axial cross‐section images and none of the specimens showed completely gap‐free areas along the entire GP‐sealer interface. Root canals filled with EndoSequence BC Sealer and AH Plus displayed 171 (37.75%) and 136 (30.02%) slices with gaps in the GP‐sealer interface and these frequencies were statistically significant (p = .000).ConclusionsAlthough none of the specimens had a gap‐free area along the entire GP‐sealer interface, oval canals filled with AH Plus showed less gaps than the ones filled with EndoSequence BC Sealer.
Prognostic impact of insulin‐like growth factor‐I and its binding proteins, insulin‐like growth factor‐I binding protein‐2 and ‐3, on adverse histopathological features and survival outcomes after radical cystectomy
Authors: Sari Motlagh Reza , Schuettfort Victor M , Mori Keiichiro , Katayama Satoshi , Rajwa Pawel , Aydh Abdulmajeed , Grossmann Nico C , Laukhtina Ekaterina , Pradere Benjamin , Mostafai Hadi , Quhal Fahad , Abufaraj Mohammad , Lee Richard , Karakiewicz Pierre I , Lotan Yair , Comprate Eva , Moschini Marco , Gontero Paolo , Shariat Shahrokh F 
Published: April 2022

ObjectivesInsulin‐like growth factor‐I and its binding proteins are involved in cancer development, progression, and metastasis. In urothelial carcinoma, the impact of this pathway is still poorly investigated. The present large cohort study aimed to evaluate the association of preoperative circulating levels of insulin‐like growth factor‐I, insulin‐like growth factor‐I binding protein‐2 and ‐3 on outcomes after radical cystectomy.MethodsA retrospective cohort study of the plasma specimens from 1036 consecutive urothelial carcinoma patients who were treated with radical cystectomy. The primary and secondary outcomes were adverse histopathological features and survival outcomes. Binominal logistic regression and multivariable Cox regression analyses were performed to assess the association of plasma levels of insulin‐like growth factor‐I, insulin‐like growth factor‐I binding protein‐2 and ‐3 with outcomes.ResultsOn multivariable analysis adjusting for the effects of preoperative variables, lower insulin‐like growth factor‐I binding protein‐2 levels were associated with an increased risk of lymph node metastasis and (any non‐organ confined disease) any non‐organ confined disease. Insulin‐like growth factor‐I binding protein‐3 levels were also inversely independently associated with lymph node metastasis. Receiver operating characteristic curve analysis showed that the addition of insulin‐like growth factor‐I binding proteins biomarkers to a reference model significantly improved the discriminating ability for the prediction of lymph node metastasis (+10.0%, P < 0.001). On multivariable Cox regression models, lower levels of both insulin‐like growth factor‐I binding protein‐2 and ‐3 plasma levels were associated with recurrence‐free survival, cancer‐specific survival, and overall survival. insulin‐like growth factor‐I binding protein‐2 and ‐3 levels and improved the discrimination of a standard reference model for the prediction of recurrence‐free survival, cancer‐specific survival, and overall survival (+4.9%, 4.9%, 2.3%, respectively).ConclusionsPreoperative insulin‐like growth factor‐I binding protein‐2 and ‐3 are significantly associated with features of biologically and clinically aggressive urothelial carcinoma. These biomarkers improved prognostic urothelial carcinoma models.
Developmental regulator RamRsl controls both morphological development and lincomycin biosynthesis in Streptomyces lincolnensis
Authors: Wang Ruida , Cao Yuan , Kong Fanjing , Hou Bingbing , Zhao Jiaqi , Kang Yajing , Ye Jiang , Wu Haizhen , Zhang Huizhan 
Published: April 2022

Abstract

Aims
Assessing the role of ramRsl, a gene absent in a lincomycin over-producing strain, in the regulation of morphological development and lincomycin biosynthesis in Streptomyces lincolnensis.

Methods and Results
The gene ramRsl was deleted from the wild-type strain NRRL 2936 and the ΔramR mutant strain was characterized by a slower growth rate and a delayed morphological differentiation compared to the original strain NRRL 2936. Furthermore, the ΔramR produced 2.6-fold more lincomycin than the original strain, and consistently the level of expression of all lincomycin cluster located genes was enhanced at 48 and 96 h in the ΔramR. Complementation of ΔramR with an intact copy of ramRsl restored all wild-type features, whereas the over-expression of ramRsl led to a reduction of 33% of the lincomycin yield. Furthermore, the level of expression of glnR, bldA and SLCG_2919, three of known lincomycin biosynthesis regulators, was lower in the ΔramR than in the original strain at the early stage of fermentation and we demonstrated, using electrophoretic mobility shift assay and XylE reporter assay, that glnR is a novel direct target of RamR.

Conclusions
Altogether, these results indicated that, beyond promoting the morphological development, RamR regulates negatively lincomycin biosynthesis and positively the expression of the nitrogen regulator GlnR.

Significance and Impact of the Study
We demonstrated that RamR plays a negative role in the regulation of lincomycin biosynthesis in S. lincolnensis. Interestingly, the deletion of this gene in other antibiotic-producing Streptomyces strains might also increase their antibiotic-producing abilities.
Information accuracy and collusion
Authors: Colombo Stefano , Pignataro Aldo 
Published: April 2022

AbstractIn this study, we investigate firms' ability to collude when price discrimination based on the inherited market is possible, but the information accuracy about the inherited market is imperfect. We show that the level of information accuracy affects collusion sustainability nonmonotonically, according to the starting level of information and the consumers' reservation price. Moreover, we show that banning price discrimination might increase the sustainability of tacit collusion.
An analysis of the degree of circularity of the wood products industry in Europe
Authors: Diaz‐Balteiro Luis , Romero Carlos , García de Jalón Silvestre 
Published: April 2022

AbstractBy developing products derived from materials included in what is nowadays called bioeconomy, the wood products industry is today receiving considerable attention for its potential to provide more environment‐friendly materials. At the same time, this and other industries are transforming to obtain more circular production systems. This study aims to analyze circularity in this type of industry at a European Union level, by establishing a ranking of countries based on their performance in an aggregate circularity index. This task has been set up by taking an initial joint set of indicators for all countries and covering a time horizon of up to 19 years. After proceeding to normalize those indicators and applying an analysis of correlation, a biannual ranking (from 2008 to 2018) was made, using for this purpose a multicriteria decision‐making model that includes three different types of solutions. Next, a statistical model that helped to explain the rankings previously obtained was proposed, in which a set of 15 explanatory variables were defined. The results showed that Sweden, and to a lesser extent Portugal, are the countries presenting a more circular wood products industry, whereas the Benelux countries give the worst result. Moreover, the statistical models showed that the variables related to trade had a negative relationship with circularity, but some of them exerted a strong effect, such as the ratio “production/exports.” Global competitiveness also tended to diminish wood circularity. Other variables, like those related to research and development, had a strong effect positively linked to circularity.
Effects of arginine glutamate (RE:pair) on wound healing and skin elasticity improvement after CO2 laser irradiation
Authors: Kwon Koo Chul , Won Jong Gu , Seo Ji Hyun , Kwon Oh Sun , Kim Eun Hye , Kim Mi‐Sun , Park Sang‐Wook 
Published: April 2022

AbstractBackgroundGlutamic acid is known to be effective for keratinocyte proliferation, but its dermatological application is limited due to its poor solubility in water and various solvents.AimHere, the efficacy of the arginine glutamate ion pair (named as RE:pair) for recovering damaged skin and improving skin elasticity was investigated through the analysis of keratinocyte proliferation and collagen synthesis.MethodsFollowing the structural analysis of RE:pair using spectroscopic methods, a scratch assay, and Pro‐Collagen I ELISA, skin tissue changes in wound‐induced artificial skin, changes in wound area after laser wound induction, and the sensory evaluation of skin improvement were investigated.ResultsAs a result of scratch assay, wound recovery of 94.55% ± 9.57% was confirmed at 10 ppm RE:pair treatment. When evaluation of expression efficacy of procollagen type I, it was found that the expression rate was increased by 32.47% ± 5.62% compared with the control group. Further, the upregulation of the proliferation marker Ki‐67 and filaggrin expression in the damage‐induced artificial skin was verified. Clinically, the improvement was subjectively verified in terms of the reduction of the wound area, the restoration of the barrier, the improvement of skin elasticity, and through the sensory experience of skin improvement.ConclusionRE:pair shows a greater therapeutic effect than the individual effects of its constituent amino acids and those of the simple mixtures of these compounds. RE:pair exerts its therapeutic action by promoting the proliferation of keratinocytes and enhancing collagen synthesis in fibroblasts. Accordingly, it can be used throughout the cosmetic industry as an effective amino acid wound healing and skin elasticity improving material.
Adapting parent‐focused interventions for diverse caregivers of children with intellectual and developmental disabilities: Lessons learned during global crises
Authors: Vanegas Sandra B. , Dueñas Ana D. , Kunze Megan , Xu Yue 
Published: April 2022

AbstractParent‐focused interventions have been designed to provide training and support to caregivers who are essential in achieving positive outcomes for children with intellectual and developmental disabilities (IDD). In 2020, significant crises, including the COVID‐19 pandemic and continued racial tensions, profoundly impacted the livelihood of children with IDD and their families. Many ongoing efforts to address disparities among this population were halted temporarily and required further adaptations. Researchers adapted interventions and support to address the disparities impacting children with IDD and their families with limited guidance. We provide a descriptive case analysis of four parent‐focused interventions that responded to the global crises to continue serving children with IDD and their families. The four distinct programs were based on applied behavior analysis and naturalistic, developmental‐behavioral paradigms that were culturally adapted for families of young children with IDD from diverse cultural and socioeconomic backgrounds. We present the qualitative reports on the challenges and benefits that arose with adapting the four parent‐focused interventions for telehealth implementation. We focused specifically on adaptations made in recruitment and retention, instrumentation and measurement, research staff training, and intervention delivery. We synthesize our experience with challenges and solutions in adapting parent‐focused interventions for racially/ethnically and socioeconomically diverse children with IDD and their families. We conclude with recommendations for researchers and practitioners on methods for adapting parent‐focused interventions to address the significant health disparities that impact racially, ethnically, and socioeconomically diverse children with IDD and their families.
Identification of canine osteoarthritis using an owner‐reported questionnaire and treatment monitoring using functional mobility tests
Authors: Wright A. , Amodie D. M. , Cernicchiaro N. , Lascelles B. D. X. , Pavlock A. M. , Roberts C. , Bartram D. J. 
Published: April 2022

ObjectivesTo investigate the diagnostic value of an owner‐completed canine osteoarthritis screening checklist to help identify previously undiagnosed osteoarthritis cases, and assess their response to carprofen treatment by monitoring pain and functional mobility.Materials and MethodsDogs (n=500) whose owners reported ≥1 positive response to the osteoarthritis checklist were examined to identify dogs with previously undiagnosed osteoarthritis. Eligible dogs (n=133) were evaluated for pain and video mobility analysis by Helsinki Chronic Pain Index and visual analogue scale scores, respectively, following carprofen treatment, administered for 30 days (n=95) or up to 120 days (n=38). Dogs were filmed at clinics performing activities (walking, jogging, sitting/lying, walking up and down stairs), and scored at days 0, 30 and 120 using visual analogue scale by an independent blinded expert.ResultsA diagnosis of osteoarthritis was confirmed by a veterinarian in 38% (188 of 500) of dogs. Balance of sensitivity and specificity across the original group of nine screening questions was optimised to approximately 88 and 71%, respectively, after elimination of three questions. Pain measured by Helsinki Chronic Pain Index and functional mobility improved over time in response to treatment with carprofen. Mean ability scores for activities significantly improved between days 0 and 30 for walking, jogging, sitting/lying and walking down stairs, and days 0 and 120 for sitting/lying and walking up stairs.Clinical SignificanceMore osteoarthritis cases were identified in study dogs than previous prevalence estimates, indicating the screening checklist's potential to help identify for further evaluation cases that could otherwise remain undiagnosed. Improvements in function were demonstrated after carprofen treatment.