bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perilla frutescens L. alleviates trimethylamine N‐oxide–induced apoptosis in the renal tubule by regulating ASK1‐JNK phosphorylation
Authors: Yong Chen , Huang Guoshun , Ge Hongwei , Zhu Yiye , Yang Yang , Yu Yongfei , Tian Fang , Gao Kun , Zhou Enchao 
Published: November 2022

AbstractTrimethylamine N‐oxide (TMAO) is associated with overall mortality in patients with chronic kidney disease (CKD). Previous findings suggest that P. frutescens (L.) can alleviate renal injury, but its effects and mechanisms underlying alleviation of TMAO‐induced kidney damage remain unclear. In this study, a TMAO injury model, in vivo and in vitro, was established to clarify the effects and mechanisms of P. frutescens in alleviating TMAO‐induced kidney injury. The results show that TMAO (60 mM/L) can induce the activation of apoptosis signal‐regulating kinase 1 (ASK1)‐c‐Jun N‐terminal kinase (JNK), thus aggravating downstream cell apoptosis in vitro. The study also found that P. frutescens aqueous extract (PFAE) (5 mg/mL) can inhibit TMAO‐induced apoptosis by downregulating ASK1‐JNK phosphorylation. In the in vivo experiments, it was demonstrated that TMAO can increase the levels of blood urea nitrogen and cystatin C, aggravating renal tubular epithelial apoptosis. The results also show that PFAE can reduce TMAO‐induced renal damage by inhibiting ASK1‐JNK phosphorylation in vivo. Our findings confirmed that P. frutescens can alleviate TMAO‐induced renal tubule apoptosis by regulating ASK1‐JNK phosphorylation, indicating that P. frutescens may be an effective treatment for alleviating TMAO damage in CKD.
Safety assessment and adverse drug reaction reporting of tea tree oil (Melaleuca aetheroleum)
Authors: Bekhof Anne‐Sophie M. W. , van Hunsel Florence P. A. M. , van de Koppel Sonja , Woerdenbag Herman J. 
Published: November 2022

AbstractTea tree (Melaleuca alternifolia) essential oil is widely used as an antiseptic. It mainly consists of monoterpenes with terpinen‐4‐ol as the major constituent. The aim of this study was to review literature on safety data about tea tree oil and to assess its safety by investigating 159 cases of adverse reactions possibly caused by the oil, reported to the World Health Organization (WHO) from December 1987 until September 2021. To extract these data, VigiBase, the WHO global database of individual case safety reports maintained by the Uppsala Monitoring Centre (UMC), was used. All cases were categorized and analysed and 16 serious cases further assessed. It was concluded that tea tree oil should never be administered orally, as it can lead to central nervous system depression and pneumonitis. Applied topically, skin disorders may occur, especially when the oil had been exposed to light or air. This yields monoterpene oxidation products, being potent skin irritants. Tea tree oil stored under appropriate conditions and not exceeding the expiration date should be considered safe to use by non‐vulnerable people for non‐serious inflammatory skin conditions, although the occurrence of adverse reactions such as contact allergies is difficult to predict.
Bifurcation based quadratic feedback control for Moore‐Greitzer model with surge and multiple stall modes
Authors: Su Ning , Wang Yong 
Published: November 2022

AbstractWe consider the ‐mode truncation of the Moore‐Greitzer partial differential equation model for axial compressors with bleed valve as actuator. It is well known that all the rotating stall modes are linearly unstabilizable past the peak of the compressor characteristic. By using the center manifold and normal form reduction, we obtain a model describing the nonlinear interactions of rotating stall and surge modes when the compressor operates in a neighborhood of the peak pressure rise. The normal form is a special class of the the famous Lotka–Volterra system. Typically, there are equilibria as the throttle coefficient varies. We analyze the stability of these equilibria for the normal form, and interpret their relevance to the robustness of the nominal equilibrium near the peak pressure rise. We also derive the necessary and sufficient conditions for stabilizing the peak of the characteristic using a quadratic feedback control law.
Event‐triggered H∞ control for switched interval type‐2 fuzzy systems under denial‐of‐service
Authors: Qu Hanqing , Zhao Jun 
Published: November 2022

AbstractThis article focuses on the control problem for event‐triggered switched interval type‐2 (IT2) fuzzy systems under denial‐of‐service (DoS) attacks. For a switched IT2 fuzzy system subject to DoS attacks, we introduce an acknowledgment (ACK) mechanism to detect DoS attacks. With the help of the ACK detection scheme, we take the initiative to zero the input signal being attacked. In this way, when the system is being attacked, we need not consider issues of controller premise variables not being updated and the controller mode unmatched with the plant mode. Then, an event‐triggering scheme resilient to DoS is presented to reduce the bandwidth pressure of the network. Moreover, we design a sampled‐based switching law to not only achieve the stability of switched systems but also exclude the Zeno behavior of switchings. Sufficient conditions are proposed to guarantee the stability with the performance of switched IT2 fuzzy systems under DoS. Finally, we give two examples to testify the effectiveness of our results.
PPy and CQDs‐doped novel CuO nanocomposites for enhanced antibacterial activity against drug‐resistant bacteria.**
Authors: Zhang Mengmeng , Han Sha , Niu Xiaohui , Li Hongxia , Zhang Deyi , Fan Haiyan , Liu Xiaoyu , Wang Kunjie 
Published: November 2022

AbstractWith the development of modern medicine, the use of antibiotics is more and more extensive, drug‐resistant bacteria appear, the antibacterial effect of traditional antibiotics becomes weak, and new drugs are urgently needed to solve the problem of bacterial resistance. In this paper, carbon quantum dots (CQDs) were synthesized by hydrothermal method, polypyrrole (PPy) was synthesized by chemical polymerization, and PPy/CuO/CQD ternary composite was formed by composite with copper oxide. FT‐IR and XPS were used to characterize and analyze the chemical composition of PPy/CuO/CQDs. XRD results confirmed the purity of CuO, and SEM and TEM images showed that the addition of CQDs made CuO nanorods distributed evenly on PPy nanosheets. In vitro antibacterial experiments showed that PPy/CuO/CQDs nanocomposites had high antibacterial performance against Escherichia coli, Staphylococcus aureus, and methicillin‐resistant Staphylococcus aureus. When the concentration of PPy/CuO/CQDs nanocomposites was 0.5 mg/mL, the growth inhibition of the three kinds of bacteria could reach 99.99 %, and the antibacterial effect was realized by the synergistic effect of the three components. It provides a good idea for the development of antibacterial drugs in medicine. In addition, in vitro cell proliferation experiments showed that PPy/CuO/CQDs complex had an anti‐tumor effect on HepG2 cells.
Intramembrane Nanoaggregates of Antimicrobial Peptides Play a Vital Role in Bacterial Killing
Authors: Liao Mingrui , Gong Haoning , Quan Xuebo , Wang Ziwei , Hu Xuzhi , Chen Zheng , Li Zongyi , Liu Huayang , Zhang Lin , McBain Andrew J. , Waigh Thomas A. , Zhou Jian , Lu Jian Ren 
Published: November 2022

AbstractRecent developments in antimicrobial peptides (AMPs) have focused on the rational design of short sequences with less than 20 amino acids due to their relatively low synthesis costs and ease of correlation of the structure‐function relationship. However, gaps remain in the understanding of how short cationic AMPs interact with the bacterial outer and inner membranes to affect their antimicrobial efficacy and dynamic killing. The membrane‐lytic actions of two designed AMPs, G(IIKK)3I‐NH2 (G3) and G(IIKK)4I‐NH2 (G4), and previously‐studied controls GLLDLLKLLLKAAG‐NH2 (LDKA, biomimetic) and GIGAVLKVLTTGLPALISWIKRKR‐NH2 (Melittin, natural) are examined. The mechanistic processes of membrane damage and the disruption strength of the four AMPs are characterized by molecular dynamics simulations and experimental measurements including neutron reflection and scattering. The results from the combined studies are characterized with distinctly different intramembrane nanoaggregates formed upon AMP‐specific binding, reflecting clear influences of AMP sequence, charge and the chemistry of the inner and outer membranes. G3 and G4 display different nanoaggregation with the outer and inner membranes, and the smaller sizes and further extent of insertion of the intramembrane nanoaggregates into bacterial membranes correlate well with their greater antimicrobial efficacy and faster dynamic killing. This work demonstrates the crucial roles of intramembrane nanoaggregates in optimizing antimicrobial efficacy and dynamic killing.
Electronic Structure Modulation Induced by Cobalt‐doping and Lattice‐Contracting on Armor‐Like Ruthenium Oxide Drives pH‐Universal Oxygen Evolution
Authors: Gong Rui , Liu Bowen , Wang Xiaolei , Du Shichao , Xie Ying , Jia Wanqi , Bian Xinxin , Chen Zhimin , Ren Zhiyu 
Published: November 2022

AbstractExquisite design of RuO2‐based catalysts to simultaneously improve activity and stability under harsh conditions and reduce the Ru dosage is crucial for advancing energy conversion involving oxygen evolution reaction (OER). Herein, a distinctive cobalt‐doped RuOx framework is constructed on Co3O4 nanocones (Co3O4@CoRuOx) as a promising strategy to realize above urgent desires. Extensive experimental characterization and theoretical analysis demonstrate that cobalt doped in RuOx lattice brings the oxygen vacancies and lattice contraction, which jointly redistribute the electron configuration of RuOx. The optimized d‐band center balances the adsorption energies of oxygenated intermediates, lowing the thermodynamical barrier of the rate‐determining step; and meanwhile, the over‐oxidation and dissolution of Ru species are restrained because of the p‐band down‐shifting of the lattice oxygen. Co3O4@CoRuOx with 3.7 wt.% Ru delivers the extremely low OER overpotentials at 10 mA cm−2 in alkaline (167 mV), neutral (229 mV), and acidic electrolytes (161 mV), and super operating stability over dozens of hours. The unprecedented activity ranks first in all pH‐universal OER catalysts reported so far. These findings provide a route to produce robust low‐loading Ru catalysts and an engineering approach for regulating the central active metal through synergy of co‐existing defects to improve the catalytic performance and stability.
Advances in Spin Catalysts for Oxygen Evolution and Reduction Reactions
Authors: Bai Haoyun , Feng Jinxian , Liu Di , Zhou Pengfei , Wu Rucheng , Kwok Chi Tat , Ip Weng Fai , Feng Wenlin , Sui Xulei , Liu Hongchao , Pan Hui 
Published: November 2022

AbstractSearching for high effective catalysts has been an endless effort to improve the efficiency of green energy harvesting and degradation of pollutants. In the past decades, tremendous strategies are explored to achieve high effective catalysts, and various theoretical understandings are proposed for the improved activity. As the catalytic reaction occurs at the surface or edge, the unsaturated ions may lead to the fluctuation of spin. Meanwhile, transition metals in catalysts have diverse spin states and may yield the spin effects. Therefore, the role of spin or magnetic moment should be carefully examined. In this review, the recent development of spin catalysts is discussed to give an insightful view on the origins for the improved catalytic activity. First, a brief introduction on the applications and advances in spin‐related catalytic phenomena, is given, and then the fundamental principles of spin catalysts and magnetic fields‐radical reactions are introduced in the second part. The spin‐related catalytic performance reported in oxygen evolution/reduction reaction (OER/ORR) is systematically discussed in the third part, and general rules are summarized accordingly. Finally, the challenges and perspectives are given. This review may provide an insightful understanding of the microscopic mechanisms of catalytic phenomena and guide the design of spin‐related catalysts.
Evolution of bridge construction by nonmetallic technologies
Authors: Kasuga Akio 
Published: November 2022

AbstractConcrete engineers and researchers have been developed durable reinforced concrete technologies for long time. However, we have not reached the goal which gives us a perfect technology against deterioration of reinforced concrete. Basically, concrete itself is high durable material. And we recognize this fact when we see Roman concrete structures are still working now. The technologies described in this article are the challenge to derive the solutions against deterioration of reinforced concrete. This research and development have been taking for about 30 years. Then a non‐metallic highway bridge was built in 2020 with the key technologies of aramid fiber tendons, fiber‐reinforced concrete, and butterfly web.
Adsorption of Safranin dye, an emerging contaminant from wastewater by modified bamboo (Bambusa Tulda): Characterization and column model analysis
Authors: Laskar Nirban , Kumar Upendra 
Published: November 2022

AbstractA fixed‐bed column study was studied to assess the performance of sodium bicarbonate modified Bambusa Tulda to remove Safranin from wastewater. Fourier Transform Infrared Spectroscopy analysis shows the existence of carboxyl as well as hydroxyl bonding and grouping. Scanning Electron Microscope analysis shows the enhanced structure of Bambusa Tulda before and after chemical modification, and Energy dispersive X‐ray analysis shows the existence of Na, O after chemical modification with sodium bicarbonate. The maximum removal was found at higher bed depth and low flow rate. The breakthrough analysis time and exhaust time increase with an increase in bed height. At 5 ml/min flow rate, with initial concentration of 50 mg/L and bed height of 15 cm of adsorbent, shows best removal rate of safranin dye in column analysis. The Bed Depth Service Time (BDST) model and Thomas model analysis remained similar with experiment results, which indicates that they are suitable for the design of column study. It is being concluded that sodium bicarbonate modified Bambusa Tulda is an effective, low cost and readily available adsorbent for the adsorption of Safranin from wastewater.
Three point bending and tensile properties of bio‐additive polydopamine‐coated 3D printing‐based distal ulna small locking bone plates: Future need of orthopedic implants
Authors: Sharma Shrutika , Mudgal Deepa , Gupta Vishal 
Published: November 2022

AbstractPolylactic acid (PLA)‐based implants fabricated by 3D Printing process are biocompatible, porous in nature and light in weight. These biomimetic implants can be used as an alternative to metallic implants. However, such PLA‐based implants lack mechanical strength, limiting their application in biomedical field. In the present study, direct immersion coating technique has been used for application of polydopamine coating followed by studying the effect of input process parameters such as infill density, immersion time, speed of incubator shaker and concentration of coating solution using response surface methodology (RSM)‐based approach. Analysis of variance (ANOVA) has been applied for prediction of statistical models with respect to ultimate tensile and flexural strengths. The effect of individual process parameters has been discussed using main effect plots and the interactions occurring between significant parameters has been discussed using response surface and contour plots. From the findings, it was evident that infill density was highly significant parameter followed by immersion time, speed of incubator shaker and concentration of coating solution. Also, the mechanical properties improved with increase in infill density and immersion time. However, they initially increased and then decreased with increase in speed of incubator shaker and concentration of coating solution.
Bibliometric Analysis of Existing Knowledge on Digital Transformation in Higher Education
Authors: Cruz-Cárdenas Jorge , Ramos-Galarza Carlos , Guadalupe-Lanas Jorge , Palacio-Fierro Andrés , Galarraga-Carvajal Mercedes 
Published: November 2022

AbstractHigher Education Institutions (HEIs) have been feeling great pressure to advance in digital transformation. This pressure has been intensified with the outbreak of the COVID-19 pandemic at the end of 2019. Because the digital transformation of HEIs has been attracting a growing number of publications, the present study sought to carry out a bibliometric analysis of such titles. For this purpose, 643 relevant documents were identified from the Scopus database in January 2022. The descriptive results show an accelerated growth of the relevant literature, with conference papers being the main form of publication, followed by articles, conference reviews, and book chapters. The areas with which the majority of documents were associated were computer science, followed by social science, engineering, and business and management. An analysis of the co-occurrence of terms based on the titles and abstracts enabled the identification of three thematic areas of interest: 1) digital transformation in teaching, particularly under the pressure exerted by COVID-19; 2) environmental influences on the digital transformation of HEIs; and 3) enabling technologies for digital transformation. A longitudinal analysis also based on titles and abstracts allows us to see how the primary focus shifted from the economic issue (in 2019) to the COVID issue (in 2021). This study concludes by discussing the theoretical and practical implications of the findings, demonstrating as a particularly interesting area for future research the study of the digital transformation of HEIs in a future post-COVID scenario.
New human ATM variants are able to regain ATM functions in ataxia telangiectasia disease
Authors: Ricci Anastasia , Biancucci Federica , Morganti Gianluca , Magnani Mauro , Menotta Michele 
Published: November 2022

AbstractAtaxia telangiectasia is a rare neurodegenerative disease caused by biallelic mutations in the ataxia telangiectasia mutated gene. No cure is currently available for these patients but positive effects on neurologic features in AT patients have been achieved by dexamethasone administration through autologous erythrocytes (EryDex) in phase II and phase III clinical trials, leading us to explore the molecular mechanisms behind the drug action. During these investigations, new ATM variants, which originated from alternative splicing of ATM messenger, were discovered, and detected in vivo in the blood of AT patients treated with EryDex. Some of the new ATM variants, alongside an in silico designed one, were characterized and examined in AT fibroblast cell lines. ATM variants were capable of rescuing ATM activity in AT cells, particularly in the nuclear role of DNA DSBs recognition and repair, and in the cytoplasmic role of modulating autophagy, antioxidant capacity and mitochondria functionality, all of the features that are compromised in AT but essential for neuron survival. These outcomes are triggered by the kinase and further functional domains of the tested ATM variants, that are useful for restoring cellular functionality. The in silico designed ATM variant eliciting most of the functionality recover may be exploited in gene therapy or gene delivery for the treatment of AT patients.
Are hypopressive and other exercise programs effective for the treatment of pelvic organ prolapse?
Authors: Bø Kari , Anglès-Acedo Sònia , Batra Achla , Brækken Ingeborg H. , Chan Yi Ling , Jorge Cristine Homsi , Kruger Jennifer , Yadav Manisha , Dumoulin Chantale 
Published: November 2022

Abstract
Introduction and hypothesis
Pelvic floor muscle training (PFMT) is effective for the treatment of pelvic organ prolapse (POP), but other exercise programs have also been promoted and used. The aim of this review was to evaluate the effect of hypopressive and other exercise programs besides PFMT for POP.

Methods
A literature search was conducted on Ovid Medline, EMBASE, CINAHL, Cochrane, PEDro, and Scopus databases from January 1996 to 30 December 2021. Only randomized controlled trials (RCTs) were included. The keywords were combinations of “pelvic organ prolapse” or “urogenital prolapse,” and “exercise therapy,” “hypopressive exercise,” “Kegel,” “pelvic floor muscle training,” “pelvic floor muscle exercises,” “Pilates,” “treatment,” “yoga,” “Tai Chi.” Methodological quality was assessed using the PEDro rating scale (0–10).

Results
Seven RCTs containing hypopressive exercise, yoga or breathing and hip muscle exercises in an inverted position were retrieved and analyzed. PEDro score ranged from 4 to 7. There was no additional effect of adding hypopressive exercise to PFMT, and PFMT was more effective than hypopressive exercise alone. The studies that included the term “yoga” included regular PFMT and thus can be classified as PFMT. Hip exercises in an inverted position added to PFMT vs PFMT alone showed better improvement in some secondary outcomes but not in the primary outcome, POP stage.

Conclusions
There are few RCTs assessing the effects of other exercise programs besides PFMT in the treatment of POP. To date, there is no evidence that other exercise programs are more effective than PFMT for POP.
Energy Correlations of Non-Integrable Ising Models: The Scaling Limit in the Cylinder
Authors: Antinucci Giovanni , Giuliani Alessandro , Greenblatt Rafael L. 
Published: November 2022

AbstractWe consider a class of non-integrable 2D Ising models whose Hamiltonian, in addition to the standard nearest neighbor couplings, includes additional weak multi-spin interactions which are even under spin flip. We study the model in cylindrical domains of arbitrary aspect ratio and compute the multipoint energy correlations at the critical temperature via a multiscale expansion, uniformly convergent in the domain size and in the lattice spacing. We prove that, in the scaling limit, the multipoint energy correlations converge to the same limiting correlations as those of the nearest neighbor Ising model in a finite cylinder with renormalized horizontal and vertical couplings, up to an overall multiplicative constant independent of the shape of the domain. The proof is based on a representation of the generating function of correlations in terms of a non-Gaussian Grassmann integral, and a constructive Renormalization Group (RG) analysis thereof. A key technical novelty compared with previous works is a systematic analysis of the effect of the boundary corrections to the RG flow, in particular a proof that the scaling dimension of boundary operators is better by one dimension than their bulk counterparts. In addition, a cancellation mechanism based on an approximate image rule for the fermionic Green’s function is of crucial importance for controlling the flow of the (superficially) marginal boundary terms under RG iterations.