bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicophotobiological Characterization of Photoaggravated Atopic Dermatitis
Authors: Rutter Kirsty J. , Farrar Mark D. , Marjanovic Elizabeth J. , Rhodes Lesley E. 
Published: July 2022

ImportancePhotoaggravated atopic dermatitis (PAD) is estimated to affect 1.4% to 16% of patients with AD but remains poorly characterized with limited published data.ObjectiveTo provide detailed clinical and photobiological characterization of PAD.Design, Setting, and ParticipantsThis case series study used cross-sectional data collected from 120 consecutive patients diagnosed with PAD from January 2015 to October 2019 at a tertiary center referral unit for photobiology.Main Outcomes and MeasuresRoutinely collected standardized clinical and photobiological data were analyzed using descriptive statistics, and regression analysis explored associations between demographic and clinical data.ResultsOf 869 patients who underwent photoinvestigation, 120 (14%) were diagnosed with PAD (69 female [58%]; median age, 45 [IQR, 31-61] years; range, 5-83 years; skin phototypes [SPTs] I-VI). Of these patients, 104 (87%) were adults. All patients had a history of AD, and most (62 of 104 [60%]) presented with sunlight-provoked or photodistributed eczema; median age at photosensitivity onset was 37 years (range, 1-72 years). Past-year Dermatology Life Quality Index score was greater than 10 for 80 of 103 adults (78%), and 82 of 119 (69%) had vitamin D (25-hydroxyvitamin D) level insufficiency or deficiency (&lt;20 ng/mL; to convert ng/mL to nmol/L, multiply by 2.496). Broadband UV radiation provocation test results were positive for 112 patients (93%). In 28 patients (23%) with abnormal monochromator phototest findings, sensitivity occurred to UV-A, UV-B, and/or visible light, and UV-A of 350 ± 10 nm was the most prevalent wavelength. Photopatch test reactions were positive for 18 patients (15%). Patients with SPTs V to VI (31 [26%]) vs SPTs I to IV (89 [74%]) were younger at photosensitivity onset (median age, 24 years [IQR, 15-37 years] vs 40 years [IQR, 25-55 years]; P = .003), were more likely to be female (23 [74%] vs 46 [52%]; P = .03), and had a lower vitamin D status and a higher frequency of abnormal monochromator phototest findings.Conclusions and RelevanceIn this case series study, PAD affected patients with different ages and SPTs and was associated with substantially impaired quality of life. The findings suggest that confirming PAD through phototesting may provide better personalized care for patients through identification of provoking wavelengths, relevant photocontact allergies, and appropriate photoprotection advice.
All‐Inorganic Perovskite Single‐Crystal Photoelectric Anisotropy
Authors: Dong Shunhong , Hu Zhi‐Yi , Wei Ping , Han Jingru , Wang Zhao , Liu Jing , Su Bao‐Lian , Zhao Dongyuan , Liu Yong 
Published: July 2022

AbstractEngineering surface structure can precisely and effectively tune the optoelectronic properties of halide perovskites, but are incredibly challenging. Herein, the design and fabrication of uniform all‐inorganic CsPbBr3 cubic/tetrahedral single‐crystals are reported with precise control of the (100) and (111) surface anisotropy, respectively. By combining with theoretical calculations, it is demonstrated that the preferred (100) surface engineering of the CsPbBr3 single‐crystals enables a lowest surface bandgap energy (2.33 eV) and high‐rate carrier mobility up to 241 μm2 V‐1 s‐1, inherently boosting their light‐harvesting and carrier‐transport capability. Meanwhile, the polar (111) surface induces ≈0.16 eV upward surface‐band bending and ultrahigh surface defect density of 1.49 × 1015 cm‐3, which is beneficial for enhancing surface‐defects‐catalyzed reactions. The work highlights the anisotropic surface engineering for boosting perovskite optoelectronic devices and beyond.
A Low‐Surface‐Tension Strategy to Construct Ultrathin Reduced Graphene Oxide as Lithiophilic Matrix for Lithium Metal Anode
Authors: Zhang Ying , Sun Jing , Liu Wen , Niu Zanyao , Yan Yang , Qiao Lizhen , Wu Na 
Published: July 2022

AbstractLithium metal is regarded as “holy grail” in the secondary rechargeable batteries. However, irregular Li deposition and dead lithium during the plating/striping process lead to serious safety issues and rapid capacity decay. The low conductivity of matrix and inhomogeneous ion transfer result in the growth of lithium dendrite and thus the low coulombic efficiency. Here, the authors propose to solve this issue by constructing highly conductive matrix with regulated charge transfer. A low surface tension (LST) strategy is adopted to construct ultrathin reduced graphene oxide (UrGO) to storage Li. The ultrathin and loose structure promise UrGO with high conductivity and the uniformly distributed residue oxygen‐containing groups helps to induce the uniform deposition of lithium due to the improved affinity to Li. The obtained UrGO with high conductivity shows a low lithium nucleation overpotential. The UrGO@Li electrode reveals an outstanding electrochemical stability with a high coulombic efficiency of 98.5% for over 300 cycles. The good performances of full cell also indicate the successful design of the UrGO matrix and the LST strategy provides a new vision for designing highly conductive graphene‐based porous materials.
Bandgap Engineering of Cesium Lead Halide Perovskite CsPbBr3 through Cu Doping
Authors: Wu Qiaoqian , Li Jinping , Xue Shaoming , Zhao Yiting , Liu Fangchao , Huo Qiuhong , Mi Jun , Guan ChengBo , Cong Wei‐Yan , Lu Ying‐Bo , Ren Junfeng 
Published: July 2022

AbstractCu‐doped CsPbBr3 with strong blue emissions is a potentially ideal material for high‐quality light‐emitting diode (LED) devices. This study thoroughly analyzes the influence of a Cu dopant on CsPbBr3 materials through a series of theoretical investigations. Two artificial CsPbBr3 supercells are constructed, and their electronic properties are analyzed. Additionally, the antibonding nature of the conduction band minimum (CBM) and valance band maximum (VBM) of CsPbBr3 is elucidated. The results indicate that a Cu dopant can only alter the local lattice around it, not the entire lattice. Moreover, the CBM and VBM deformation potentials of CsPbBr3 behave differently. Therefore, the energetic shift of VBM is more sensitive to the shrinkage of lattice due to the smaller energy difference between the constituent orbitals, leading to a bandgap reduction with the lattice contraction. This study reveals that the two critical reasons for the increase of bandgap are the contribution of Cu‐3d orbitals to the VBM and the localized lattice distortion caused by Cu impurity. Therefore, this work clarifies how Cu impurities improve the blue light emitting performance of CsPbBr3 systems.
NFAT1 Orchestrates Spinal Microglial Transcription and Promotes Microglial Proliferation via c‐MYC Contributing to Nerve Injury‐Induced Neuropathic Pain
Authors: Jiang Bao‐Chun , Ding Ting‐Yu , Guo Chang‐Yun , Bai Xue‐Hui , Cao De‐Li , Wu Xiao‐Bo , Sha Wei‐Lin , Jiang Ming , Wu Long‐Jun , Gao Yong‐Jing 
Published: July 2022

AbstractPeripheral nerve injury‐induced spinal microglial proliferation plays a pivotal role in neuropathic pain. So far, key intracellular druggable molecules involved in this process are not identified. The nuclear factor of activated T‐cells (NFAT1) is a master regulator of immune cell proliferation. Whether and how NFAT1 modulates spinal microglial proliferation during neuropathic pain remain unknown. Here it is reported that NFAT1 is persistently upregulated in microglia after spinal nerve ligation (SNL), which is regulated by TET2‐mediated DNA demethylation. Global or microglia‐specific deletion of Nfat1 attenuates SNL‐induced pain and decreases excitatory synaptic transmission of lamina II neurons. Furthermore, deletion of Nfat1 decreases microglial proliferation and the expression of multiple microglia‐related genes, such as cytokines, transmembrane signaling receptors, and transcription factors. Particularly, SNL increases the binding of NFAT1 with the promoter of Itgam, Tnf, Il‐1b, and c‐Myc in the spinal cord. Microglia‐specific overexpression of c‐MYC induces pain hypersensitivity and microglial proliferation. Finally, inhibiting NFAT1 and c‐MYC by intrathecal injection of inhibitor or siRNA alleviates SNL‐induced neuropathic pain. Collectively, NFAT1 is a hub transcription factor that regulates microglial proliferation via c‐MYC and guides the expression of the activated microglia genome. Thus, NFAT1 may be an effective target for treating neuropathic pain.
Wireless Multiferroic Memristor with Coupled Giant Impedance and Artificial Synapse Application
Authors: Wang Yao , Xiao Rui , Xiao Ning , Wang Zhongfeng , Chen Lei , Wen Yumei , Li Ping 
Published: July 2022

AbstractInternet of things (IoT) becomes part of everyday life across the globe, whose nodes are able to sense, store, and transmit information wirelessly. However, the IoT nodes based on von Neumann architectures realize the memory, computing and communication functions with physical separated devices, which result in severe power consumption and computation latency. In this study, a wireless multiferroic memristor consisting of Metglas/Pb(Zr0.3Ti0.7)O3‐1 mol% Mn/Metglas laminate is proposed, which integrates the storage, processing, and wireless communication of information in a single device at the first time. First, a power efficient impedance modulation mechanism is explored for the multiferroic memristor, which couples electric field modulated giant magnetoimpedance (GMI) of magnetostrictive Metglas with varied impedance of ferroelectric Pb(Zr0.3Ti0.7)O3‐1 mol% Mn due to the gradual polarization switching. Meanwhile a pair of multiferroic memristors are used to transmit and receive stored information wirelessly, which facilitate the application of memristor in the IoT. Furthermore, the experimental study demonstrates that the memristor can mimic the synaptic plasticity, such as long‐term potentiation, depression, and spiking‐timing‐dependent plasticity, and it also reveals the capability of pattern learning with a memristor network. This work paves a way toward the IoT nodes integrating both brain inspired computing and wireless communication functions.
Polymer/dye blends: Preparation and optical performance: A short review
Authors: Plouzeau Maud , Piogé Sandie , Peilleron Frédéric , Fontaine Laurent , Pascual Sagrario 
Published: July 2022

AbstractThis review focuses on the optimization of the optical performance of polymer/dye blends in which dyes are physically dispersed in polymer matrices. The optimization of the optical performance of polymer/dye blends is discussed in terms of: (i) the preparation procedure of polymer/dye blends (melt processing is considered particularly effective for producing polymer/dye blends with optimal dye distribution); (ii) mechanical and thermal solicitations after polymer/dye blend preparation; (iii) the polymer matrix, whose affinity for the dye and crystallinity affects the optical performance the polymer/dye blend; and (iv) the dye, whose chemical structure and concentration are significant determinants of the optical properties of polymer/dye blends.
A quality improvement apprenticeship: Gross anatomy in the time of Covid‐19
Authors: Hatcher April R. , Pearson A. Scott , Platt Kristen M. 
Published: July 2022

AbstractThe study of anatomy is a team‐driven field in which anatomy instruction occurs in small groups in the laboratory with one faculty member guiding students through each anatomical region. One laboratory experience may include several small group instructors in one simultaneous learning session. In comparison, the education of future gross anatomists often happens in an apprenticeship model, where the optimal learning outcomes are met through training with an experienced mentor. It was the vision of the authors to further their education through initiating an inter‐institutional exchange to apprentice with innovative mentors in order to bring new ideas back to their own gross anatomy courses. The Southeastern Conference, a consortium of the Universities in the Southern region of the United States often associated with intercollegiate sports, has a host of academic initiatives in addition to the athletic emphasis. The Southeastern Conference Faculty Travel Program is one mechanism by which the organization promotes scholarly excellence. In this case, the Faculty Travel Program provided a way for authors from the University of Kentucky to visit a nearby institution, Vanderbilt University, and learn from like‐minded anatomy educators, with the goal of incorporating changes in their courses geared toward quality improvement. After this implementation, positive themes emerged in the student feedback on course evaluations. However, the collaboration was interrupted by the onset of the Covid‐19 pandemic. This article examines the strengths of interinstitutional apprenticeship and the benefits of such practices in a time of accelerated change in anatomical instruction.
Toward carbon‐neutral ethylene production: assessment of the application potential of bio‐ethylene production pathways in China
Authors: Li Haoran , Zhang Shuyuan , Zhou Jian , Wang Zhiyin , Zhao Xuebing , Qiu Tong 
Published: July 2022

AbstractThe production of bio‐ethylene is a promising way to replace fossil‐based ethylene production, reducing greenhouse gas emissions and working towards China's carbon neutrality goals. This study elaborates on five bio‐ethylene technological pathways: first‐ and second‐generation bioethanol dehydration, direct and indirect thermochemical synthesis, and methanol‐to‐olefins (MTO). It retrieves information about them from commercial patents and the scientific literature, and comprehensively assesses their potential for application in large‐scale ethylene production in China. The techno‐economic feasibility of these five technological pathways is discussed in terms of feedstock availability, investment level, technological development level, and political issues such as the carbon neutrality goal to which China's government is committed. Overall, two pathways (indirect thermochemical synthesis and MTO) exhibited competitive minimum ethylene selling prices at 5243 yuan/t (822 USD t–1) and 6767 yuan/t (1061 USD t–1), respectively, of which both are lower than the average ethylene market price of 7000 yuan/t (1098 USD t–1). In comparison with the conventional fossil‐derived ethylene, bio‐ethylene could decrease carbon emission by 3.2%–15.1% under a scenario of 20% bio‐ethylene substitution in 2019, showing promising potential for decarbonizing the ethylene industry and contributing to the achievement of China's carbon neutrality goals. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.
Synthesis and effects of co‐dopants (La3+, Sm3+, Mn2+, Nd3+, V5+, Y3+) on photoluminescence of SrAl2O4:Dy3+ phosphor
Authors: Karacaoglu Erkul 
Published: July 2022

AbstractIn this research, the co‐dopant effects on photoluminescence (PL) properties of SrAl2O4:Dy3+ phosphors were studied. The phosphor powders were prepared with solid state reaction, which is the method that is frequently preferred in SrAl2O4 phosphors and efficient results are obtained in terms of PL properties. X‐ray diffraction (XRD) patterns of all co‐doped samples were fitted with pdf card#01‐034‐0379. Fourier‐transform infrared (FTIR) analysis supports the phase evolution determined in the XRD results. PL examinations started with the SrAl2O4 that was synthesized with the addition of boron, and then continued with the doped/and co‐doped samples. Except for the Sm3+ co‐doped phosphor, PL data of characteristic Dy3+ transitions were obtained for other lanthanide and metal ion co‐dopants. The strongest PL intensity was demonstrated in the SrAl2O4:Dy3+,V5+. SrAl2O4:Dy3+,Sm3+ phosphor shows both the Dy3+ and Sm3+ ions transition related peaks appeared in the same spectrum. In the continuation of the studies, SrAl2O4:Dy3+,Sm3+ and SrAl2O4:Dy3+,V5+ powders were immersed in water for 2 h. Regardless of the presence of Dy3+ luminescent centers and other co‐dopants, broadband and intense blue emission peak at 445 nm was recorded which is directly related to newly formed phases by the decomposition of SrAl2O4.
Synthesis and study on aggregation behaviours in liquid phase of three prepared cyanine dyes
Authors: Xu Mengcui , Li Xipeng , Zeng Qin , Zhang Tao 
Published: July 2022

AbstractHere we investigate the aggregation behaviours of three prepared dyes in the liquid phase to pick out one possessing J‐aggregation characteristic that is of significant interest for organic materials used in multiple bio‐applications. The self‐assembly of dyes usually leads to various forms of aggregates, for example, H‐aggregates or J‐aggregates and it is easy to distinguish bathochromic J‐aggregation from hypsochromic H‐aggregation using UV/vis light spectroscopy. Enlightened by the cyanine dyes that have shown a great tendency to self‐associate, we designed and synthesized three cyanine dyes: Cy7‐Ph, DCy7‐Ph, and SN‐Cy7‐Ph, followed by the study of the influence of multiple factors on their aggregation behaviours, including solvent polarity, ionic strength, and temperature. Finally, we found that of the three molecules only SN‐Cy7‐Ph could self‐assemble into J‐aggregates conveniently and stably in the aqueous phase under normal conditions.
Aristolactam I inhibits cell migration and invasion through regulation of Twist1 in MDA‐MB‐231 breast cancer cells
Authors: Lee Sewoong , Lee Junho , Cho Sayeon 
Published: July 2022

AbstractTriple‐negative breast cancer (TNBC) is one of the most difficult cancer types to treat. Because three key receptors are absent in these cancer cells, the cells bypass the human immune system and chemotherapy does not work well. Aristolactam I (AL‐I) is a natural compound in the plant genus Aristolochia. Previous studies have shown that aristolactam variants exhibit an inhibitory effect on several bioactive cancer developments. However, the regulatory mechanism and biological activity of AL‐I in TNBC cell lines have not been identified. In this study, AL‐I affected an increase in E‐cadherin expression in MDA‐MB‐231 cancer cells. AL‐I increased E‐cadherin mRNA expression by down‐regulating Twist1 protein expression. The novel anticancer effect of AL‐I was confirmed to be inhibition of the development of breast cancer cells through reduced cell mobility.
Three‐dimensional morphological revealing of human placental villi with common obstetric complications via optical coherence tomography
Authors: Ni Guangming , Zhong Junming , Gao Xuemei , Wu Renxiong , Wang Wenjing , Wang Xiaoshan , Xie Yao , Liu Yong , Mei Jie 
Published: July 2022

AbstractPlacental villi play a vital role in human fetal development, acting as the bridge of material exchange between the maternal and fetal. The abnormal morphology of placental villi is closely related to placental circulation disorder and pregnancy complications. Revealing placental villi three‐dimensional (3D) morphology of common obstetric complications and healthy pregnancies provides a new perspective for studying the role of the placenta and its villi in the development of pregnancy diseases. In this study, we established a noninvasive, high‐resolution 3D imaging platform via optical coherence tomography to reveal placental villi 3D morphological information of diseased and normal placentae. For the first time, 3D morphologies of placental villous tree structures in common obstetric complications were quantitatively revealed and corresponding 3D information could visualize the morphological characteristics of the placental villous tree from a more intuitive perspective, providing helpful information to the study of fetal development, feto‐maternal material exchange, and gestational complications treatment.
Identification of PIK3CG as a hub in septic myocardial injury using network pharmacology and weighted gene co‐expression network analysis
Authors: Liu Qiong , Dong Yushu , Escames Germaine , Wu Xue , Ren Jun , Yang Wenwen , Zhang Shaofei , Zhu Yanli , Tian Ye , Acuña‐Castroviejo Darío , Yang Yang 
Published: July 2022

AbstractSepsis causes multiple organ injuries, among which the heart is one most severely damaged organ. Melatonin (MEL) alleviates septic myocardial injury, although a systematic and comprehensive approach is still lacking to understand the precise protective machinery of MEL. This study aimed to examine the underlying mechanisms of MEL on improvement of septic myocardial injury at a systematic level. This study integrated three analytic modalities including database investigations, RNA‐seq analysis, and weighted gene co‐expression network analysis (WCGNA), in order to acquire a set of genes associated with the pathogenesis of sepsis. The Drugbank database was employed to predict genes that may serve as pharmacological targets for MEL‐elicited benefits, if any. A pharmacological protein–protein interaction network was subsequently constructed, and 66 hub genes were captured which were enriched in a variety of immune response pathways. Notably, PIK3CG, one of the hub genes, displayed high topological characteristic values, strongly suggesting its promise as a novel target for MEL‐evoked treatment of septic myocardial injury. Importantly, molecular docking simulation experiments as well as in vitro and in vivo studies supported an essential role for PIK3CG in MEL‐elicited effect on septic myocardial injury. This study systematically clarified the mechanisms of MEL intervention in septic myocardial injury involved multiple targets and multiple pathways. Moreover, PIK3CG‐governed signaling cascade plays an important role in the etiology of sepsis and septic myocardial injury. Findings from our study provide valuable information on novel intervention targets for the management of septic myocardial injury. More importantly, this study has indicated the utility of combining a series of techniques for disease target discovery and exploration of possible drug targets, which should shed some light on elucidation of experimental and clinical drug action mechanisms systematically.