bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of the Covid-19 pandemic on medication reconciliation in frail elderly people at hospital discharge.Professional perception
Authors: ROJAS-OCAÑA MARIA JESÚS , ARAUJO-HERNANDEZ MIRIAM , GARCÍA-NAVARRO SONIA , BAZ-MONTERO SERVANDO MANUEL , MACIAS-COLORADO MARIA EULALIA , GARCIA-NAVARRO ESPERANZA BEGOÑA 
Published: March 2022

Abstract
Background The current demographic panorama in Spain corresponds to an aging population; this situation is characterized by the need to care for an elderly population, which generates polymedicated and pluripathological individuals. Polymedication is a criterion of frailty in the elderly and a risk factor for mortality and morbidity due to the increased risk of drug interactions and medication errors. A high percentage of medication errors occur at hospital admission or discharge, i.e. in the transition of patients between different levels of care. A key element to prevent or avoid these errors would be treatment reconciliation, something that should be coordinated between different areas of action and with a multidisciplinary approach.There are numerous studies that measure reconciliation at hospital discharge, at admission and even the methodology of reconciliation, but we have not found many studies that measure reconciliation in the context of the pandemic from the point of view of health professionals, their perception, difficulties and strategies carried out, which is essential to begin to glimpse solutionsMethods Qualitative study based on 21 in-depth interviews and two discussion groups, between Jan-uary and April 2021 (13 nurses, 8 doctors, in rural and urban areas). The discourse was ana-lyzed according to the Taylor-Bodgan model and processed using Atlas.ti softwareResults The areas altered by the health crisis were access to patients, their reconciliation of medication, and changes in the care modality: greater use of telephone communication, changes in work organization, time dedicated to patient care and family work.Difficulties encountered during Covid-19: change in medication format, specific characteristics of the patient and their pathologies, and difficulties arising from communication with the patient and their family.The strategies applied: the collaboration of home assistants and caregivers, emphasis on patient-health professional communication and the use of Information and Communication Technologies (ICT).Conclusion The discharge has been interrupted by the health crisis caused by Covid-19, in the traditional access of patients and by the remote care modalities generated by telemedicine
Bladder cancer in patients with HIV infection: a retrospective study of 14 cases
Authors: Yu Zhang , Wenrui Xue , Xuyu Li , Xudong Wang , Pengfei Yuan , Qingjun Liu , Zhixing Han , Haijian Zhang , Shiqi Ji 
Published: March 2022

Abstract
Purpose: This study was intended to determine whether differences existed between bladder cancers in HIV-infected patients compared to those in the general population. Patients and methods: In this study, 14 patients with HIV infection were found also to have bladder cancer, treated in Beijing Ditan Hospital and Beijing You 'an Hospital from 2013 to 2021. The retrospective study parameters analyzed included HIV infection route, regular treatment, viral load and number of CD4+T lymphocytes prior to surgery, and preoperative laboratory examination. Details specific to bladder cancer included pathological stage and grade, treatment, recurrence at 3 months and longer-term follow-up. Results: The study comprised 13 males (93%) and 1 female (7%), with a median age of 50.5 years, of whom only 9 patients received regular antiretroviral therapy after HIV infection. The median value of CD4+T lymphocytes detected before surgery was 368 cells/μL (range: 147cells/μL-759cells /μL). Other preoperative laboratory results were as follows (median counts): WBC, 6.165×109 /L; erythrocytes, 4.16×1012 /L; hemoglobin, 214.5 g/L; platelets, 143×109 /L; creatinine, 70.85μmol/L; and serum albumin, 41.5 g/L. All patients were treated surgically, 11 of whom had non-muscle invading bladder cancer that underwent localized tumor resection (plus epirubicin bladder infusion) , and the remaining 3 patients had tumor invasion of the muscle that required radical resection (plus postoperative chemotherapy). The cancers were all urothelial, 5 high-grade and 9 low-grade histologically. At three months postoperatively, 3 cases had recurred and were re-excised, 7 had no evidence of recurrence, and 4 had not undergone reevaluation. On subsequent longer-term follow-up (median, 40 months), 2 patients had died[1] of unrelated causes, 10 were alive[2] including 1 with liver metastasis, and 2 were lost to follow-up.Conclusions: The clinical characteristics of HIV-positive patients with bladder cancer were similar to those of the general population with the exception of a significant earlier onset of disease. The type and stages of the bladder cancer, treatment, and outcomes of these patients were also similar to the general population. However, the cause of earlier onset of bladder cancer in HIV positive patients remains to be further elucidated.
Increased parenchymal free water may be decreased by revascularization surgery in patients with moyamoya disease
Authors: Hara Shoko , Hori Masaaki , Kamagata Koji , Andica Christina , Inaji Motoki , Tanaka Yoji , Aoki Shigeki , Nariai Tadashi , Maehara Taketoshi 
Published: March 2022

Abstract

Moyamoya disease (MMD) is a cerebrovascular disease causing steno-occlusive changes in the arteries of the circle of Willis and hemodynamic impairment. A previous study reported that parenchymal extracellular free water may be increased and neurites may be decreased in this disease population. The aim of this study was to investigate the postoperative changes in parenchymal free water and neurites and their relationship with cognitive improvement. Multishell diffusion magnetic resonance imaging was performed in 15 hemispheres of 13 adult patients with MMD (11 female, average age: 37.9 years) who had undergone revascularization surgery and 13 normal controls. Parameter maps of free water and free-water eliminated neurites were created, and regional parameter values were compared among controls, patients before the surgery and patients after the surgery. Compared with normal controls, most regions in the hemispheres of the patients showed a significant increase in free water before surgery (P≤.007) and a significant decrease in free water after surgery (P≤.001). The change in the dispersion of the white matter significantly correlated with cognitive improvement (r=-0.75). In patients with MMD, increased parenchymal free water may be decreased after surgery, and the neurite parameter may be related to cognitive improvement.
A 12-year retrospective single-center comparison of pneumonia- and non-pneumonia-related Acinetobacter baumannii complex bacteremia
Authors: Xu Jun , Xu Yulu , Zheng Xia 
Published: March 2022

Abstract
Background
Acinetobacter baumannii complex (ABC) is a group of increasingly prevalent opportunistic pathogens that cause a variety of life-threatening nosocomial infections, especially in the intensive care unit (ICU). It is unclear whether ABC bacteremia differs with infection site. This study assessed the differences between pneumonia- and non-pneumonia-related ABC bacteremia and possible independent risk factors for 30-day mortality.
Methods
The clinical data of 188 patients diagnosed with ABC bacteremia in our 29-bed ICU between January 2009 and December 2020 were collected. Of these, 44 cases (23.4%) were defined as pneumonia-related ABC bacteremia and 144 (76.6%) as non-pneumonia-related ABC bacteremia.
Results
Significant changes in the incidence of ABC bacteremia and antibiotic resistance were observed over the 12-year study, with an overall 30-day mortality rate of 61.7%. Compared with non-pneumonia-related ABC bacteremia, pneumonia-related ABC bacteremia was associated with a higher rate of hypertension, less prior tigecycline use, more carbapenem-resistant (CR) strains, and had a higher 30-day mortality rate. Univariate analysis showed that hematological malignancy, previous corticosteroid use, prior exposure to quinolone and anti-fungal agents, CR strains, monomicrobial bacteremia, respiratory tract bacteremia origin, lower albumin and higher lactate levels at the time of bacteremia, immunosuppression, septic shock, and severity of illness based on the Pitt bacteremia score, Acute Physiology and Chronic Health Evaluation II (APACHE II), and Sequential Organ Failure Assessment (SOFA) scores at the time of bacteremia were associated with poor outcomes. In multivariate analysis, immunosuppression, and higher APACHE II and SOFA scores, were risk factors for 30-day mortality. Moreover, the risk of death was 1.919 times higher in the pneumonia-related group.
Conclusions
Our study described the clinical characteristics and independent predictors of 30-day mortality in patients with pneumonia- and non-pneumonia-related ABC bacteremia. Although pneumonia-related ABC bacteremia had worse outcomes, it was not an independent risk factor for death statistically. Detection of immune status and maintenance of organ function may be effective therapeutic strategies to improve patient outcomes.
A Rapid Near-Infrared Fluorescent Probe Based on Isophorone and its Application in B16 Cell Imaging
Authors: Wang Yan-Ya , Yu Xue-Shuang , Li Xin-Jie , Liu Hong-Bo , Zhu Xi , Wang Ya-Wen , Peng Yu 
Published: March 2022

Abstract
A novel near-infrared fluorescent probe SWJT-5 based on dicyanoisophorone was synthesized. It achieved the rapid (within 40 s) and discriminative detection of Cys over Hcy and GSH with a large Stokes shift (205 nm). It showed high selectivity and sensitivity for Cys, and had an obvious enhancement of fluorescence emission. The detection limit was 0.43 μМ. This probe also had low background interference and little damage to biological samples. Therefore, SWJT-5 had been applied to bioimaging in living cells successfully.
Omicron and future public health emergencies: Sustainability and insights into support programs for healthcare providers
Authors: Dhuper Misha , Ruttan Lesley , MacGillvray Lindsey , McKay Martha , DClinPsy Adrienne Li , Stewart Donna , Abbey Susan , Berkhout Suze , Sheehan Kathleen , Schulz-Quach Christian 
Published: March 2022

Abstract
Background: The mental health of healthcare workers (HCWs) has been at the forefront throughout the COVID-19 pandemic. While workplace-based support programs have been developed in hospitals globally, few systematically collected data. While critical to their success, information on these programs and the experience of mental healthcare providers (MHP) who support colleagues is limited. The objective of this study was to explore the experiences of MHP caring for HCW colleagues within a novel workplace-based mental health support program during the COVID-19 pandemic, to provide insights on facilitators, areas for improvement and barriers to program sustainability. Methods: This qualitative study used semi-structured interviews conducted by videoconference between September 2020 to October 2021. UHN CARES (University Health Network Coping and Resilience for Employees and Staff) Program was developed during the first wave of the COVID-19 pandemic in March 2020. It supports over 21,000 staff members within the UHN, Canada’s largest academic health research institution, in Toronto, Canada. Purposive sampling was used to select 10 of the 22 MHP in the UHN CARES Program. Using a critical realism framework, key components required to sustain a successful workplace-based mental health support program for HCWs and balance the needs of MHP were determined. Results: Six psychiatrists and four psychologists with varying roles at UHN participated in 17 interviews, with repeat interviews exploring changes over time within the pandemic and program. Components which facilitated the success of the program included flexibility in scheduling, confidential health record storage, comprehensive administrative support, availability of resources and adaptive quality improvement approach. Recommendations for improvement included opportunities for peer supervision, triaging of cases, and managing HCW expectations. MHP found caring for HCWs to be meaningful and they utilized existing clinical skills during sessions. Challenges included working in a virtual setting, navigating boundaries when caring for colleagues, and managing the range of service users and their needs.Conclusions: These findings suggest how support programs can be structured for HCWs, how to provide support, and how to sustain this support, allowing health systems to balance the needs of HCWs and MHPs in preparation for future public health emergencies.
Towards More Personalized Digital Health Interventions: A Clustering Method of Action and Coping Plans to Promote Physical Activity
Authors: Schroé Helene , Carlier Stéphanie , Dyck Delfien Van , De Backere Femke , Crombez Geert 
Published: March 2022

Abstract
BackgroundDespite effectiveness of action and coping planning in digital health interventions to promote physical activity (PA), attrition rates remain high. Indeed, support to make plans is often abstract and similar for each individual. Nevertheless, people are different, and context varies. Tailored support at the content level, involving suggestions of specific plans that are personalized to the individual, is needed. The aim of this study was to investigate whether user information relates toward specific action and coping plans using a clustering method. In doing so, we demonstrate how knowledge can be acquired in order to develop a knowledge-base, which might provide personalized suggestions in a later phase.MethodsTo establish proof-of-concept for this approach, data of 59 healthy adults, including 222 action plans and 204 coping plans, were used and were collected as part of the digital health intervention MyPlan 2.0 to promote PA. As a first step, clusters of action plans, clusters of coping plans and clusters of combinations of action plans and barriers of coping plans were identified using hierarchical clustering. As a second step, relations with user information (i.e. gender, motivational stage, …) were examined using anova’s and chi2–tests.ResultsFirst, three clusters of action plans, eight clusters of coping plans and eight clusters of the combination of action and coping plans were identified. Second, relating these clusters to user information was possible for action plans: 1) Users with a higher BMI related more to outdoor leisure activities (F = 13.40,P < .001), 2) Women, users that didn’t perform PA regularly yet, or users with a job related more to household activities (X2 = 16.92,P < .001;X2 = 20.34,P < .001;X2 = 10.79,P = .004; respectively), 3) younger users related more to active transport and different sports activities (F = 14.40,P < .001). However, relating clusters to user information proved difficult for the coping plans and combination of action and coping plans.ConclusionsThe approach used in this study might be a feasible approach to acquire knowledge for a knowledge-base, however more data (i.e. contextual and dynamic user information) from possible end users should be acquired in future research. This might result in a first type of context-aware personalized suggestions on the content level.Trial registrationThe digital health intervention MyPlan 2.0 was preregistered as a clinical trial (ID:NCT03274271). Release date: 6-September-2017.
The Eruption in Fagradalsfjall (2021, Iceland): How The Operational Monitoring and The Volcanic Hazard Assessment Contributed to Its Safe Access
Authors: Barsotti Sara , Parks Michelle Maree , Pfeffer Melissa Anne , Óladóttir Bergrún Arna , Barnie Talfan , Titos Manuel Marcelino , Jónsdóttir Kristín , Pedersen Gro BM , Hjartardóttir Ásta Rut , Stefansdóttir Gerður , Johannsson Thorsteinn , Arason Þórður , Gudmundsson Magnús Tumi , Oddsson Björn , Þrastarson Ragnar H , Ófeigsson Benedikt Gunnar , Vogfjörd Kristín , Geirsson Halldór , Hjörvar Tryggvi , von Löwis Sibylle , Pedersen Guðrun Nina , Sigurðsson Eysteinn Már 
Published: March 2022

Abstract
After more than a year of unrest, a small effusive eruption commenced in Fagradalsfjall on 19 March 2021. The eruption lasted six months with multiple fissure openings characterizing the first six weeks. During the eruption lava and low-level gases propagated over the complex terrain: a hyaloclastite massif with mountain peaks up to about 350 m asl with valleys in the between. It is uninhabited, but easily accessible at about 30 km distance from the Reykjavík capital area. While the eruption was on-going, more than 356,000 accesses were counted. Monitoring the onset, the eruption in real-time, forecasting the transport of gas and emplacements of lava flows, and assessing the hazards were instrumental in maintaining safe access to the area. In addition to data accessibility and interpretation, managing this volcanic crisis was possible thanks to a strong collaboration between the scientific institutions and civil protection agencies. The eruption presented an opportunity to tune, test and validate a variety of numerical models for hazard assessment as well as to refine and improve the delivery of information to the public, community members and decision makers. The monitoring team worked long hours during both the pre- and syn-eruptive phases for a safe access to the eruption site and to provide a regular flow of information. This paper reviews the eruption and its associated hazards. It also provides an overview of the monitoring setup, the adopted numerical tools and communication materials made available for informing the general public of possible eruption scenarios and exclusion zones.
Genetic Heterogeneity between some recently detected strains of Chicken Anemia Viruses in commercial young chick’s flocks.
Authors: Elsamadony Hanaa A. , Mekky Hoda M. , Fedawy Hanaa. S. , Sedeek Dalia M. , Saad Aalaa 
Published: March 2022

Abstract
Chicken anemia virus (CAV) is a serious viral infection that causes considerable impairment of immunity and severe anemia in chickens all over the world. In young chicks, significant illness and mortality are observed (2–3 weeks). The vertical route of transmission enhances the chance of infection and virus persistence among diseased flocks. This research aimed to confirm the existence of CAV in young chicks (at the age of 1–7 days) in Egypt during 2021, genetic divergence between the spreading viruses and vaccinal strains in order to improve virus control. DNA was isolated from samples that were collected, used in a targeting VP2 gene by PCR, and then characterized VP2 on a molecular level in the detected viruses. Five CAV were detected, sequenced, and submitted to Genebank under accession no MZ574095, MZ574096, MZ476999, MZ477000, MZ477001. The strains were classified into genogroups I, II, and IIIb, and one detected strain was congregated with the vaccinal strain 26P4 and Nobilis P4. Also, the VP2 protein of the five CAV isolates and Egyptian CAV showed a high Conservation score. In silico analysis of the secondary structures of VP2 proteins of Cux-1 (reference strain) and the five strains showed that the a-helix and ß-strand architectures were quite comparable in number and position. As well as, VP2 of the five CAV isolates showed the absence of an insertion or a deletion in comparison to Cux-1 in the sequenced part.
Early detection of ICU-acquired weakness in septic shock patients ventilated longer than 72 hours
Authors: Attwell Caroline , Sauterel Laurent , Jöhr Jane , Piquilloud Lise , Kuntzer Thierry , Diserens Karin 
Published: March 2022

Abstract
Purpose: ICU acquired weakness, comprising Critical Illness Polyneuropathy (CIP) and Myopathy (CIM) is associated with immobilization and prolonged mechanical ventilation. This study aims to assess feasibility of early detection of CIP and CIM by peroneal nerve test (PENT) and sensory sural nerve action potential (SNAP) screening in patients with septic shock invasively ventilated for more than 72 hours and to investigate risk factors associated with CIP and CIM. Methods: We performed repetitive PENT screening from 72 hours after intubation until detecting a pathological response. We tested SNAPs in pathological PENT to differentiate CIP from CIM. Muscle strength examination was performed in awake patients and time from intubation to first in-bed and out-of-bed mobilization were recorded.Results: Eighteen patients were screened with PENT and 88.9% had abnormal responses. Mean time between intubation and first screening was 94.38 (+ 22.41) hours. Seven patients (38.9%) had CIP, 2 (11.1%) had CIM, 1 (5.6%) had CIP and CIM, 6 (33.3%) had a pathological response at PENT associated with ICU acquired weakness but no SNAP could be performed to differentiate between CIP and CIM and 2 patients had (11.1%) had no peripheral deficit. In the patients where it could be performed, muscle strength testing concorded with electrophysiological findings. Twelve patients (66.7%) had out-of-bed mobilization 10.8 (+ 7.4) days after admission. Conclusion: CIP and CIM are frequent in septic patients and can be detected before becoming symptomatic with simple bedside tools. Early detection of CIP and CIM opens new possibilities for timely management of CIP and CIM through preventive measures such as passive and active mobilization.
Astrocytic HDAC7 Activates IKK/NF-κB Signaling to Regulate Neuroinflammation and Anxiety-like Disorders
Authors: Ye Jinwang , Zhong Suyue , Deng Yunsong , Yao Xuanbao , Liu Qiong , Wang Jian-Zhi , Xiao Shifeng 
Published: March 2022

Abstract
Class IIa histone deacetylase s (HDAC) have been shown to drive innate immune cell-mediated inflammation in the peripheral system, but their roles in cerebral inflammatory responses remain largely unknown. Here, we elucidate that HDAC7 is selectively elevated in lipopolysaccharide (LPS)-challenged astrocytes both in vivo and in vitro. We identify that HDAC7 binds to the inhibitory kappa B kinase (IKK) to promote IKKα and IKKβ deacetylation and subsequent activation, leading to the activation of nuclear factor κB (NF-κB). Astrocyte-specific overexpression of HDAC7 results in NF-κB activation, pro-inflammatory gene upregulation and anxiety-like behaviors in mice, while downregulating HDAC7 reserves LPS-induced NF-κB activation and inflammatory responses. Furthermore, pharmacological inhibition of HDAC7 by a class IIa HDAC inhibitor attenuates LPS-induced NF-κB activation, neuroinflammation and anxiety-like disorders both in vivo and in vitro. Together, our data reveal a novel mechanism of HDAC7 in astroglial inflammation and suggest that targeting HDAC7 could be a potential therapeutic strategy for the treatment of anxiety and other neuroinflammation-related diseases.