bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan pes planus dan keseimbangan statis pada anak sekolah dasar
Authors: Yasmasitha Zharah , Sidarta Nuryani 
Published: January 2022

LATAR BELAKANGKeseimbangan merupakan kemampuan tubuh untuk mempertahankan pusat massa tubuh terhadap axis tubuh untuk melawan gravitasi bumi yang dipengaruhi oleh proses sensorik atau sistem saraf, motorik atau muskuloskeletal. Salah satu faktor yang dapat menyebabkan gangguan keseimbangan pada anak yaitu, gangguan muskuloskeletal berupa kelainan bentuk telapak kaki. Hasil penelitian yang sudah ada masih menunjukkan kontroversi sehubungan dengan hal tersebut. Penelitian ini dibuat untuk melihat lebih lanjut hubungan pes planus (kaki datar) dengan keseimbangan statis terutama pada anak sekolah dasar.
METODEPenelitian menggunakan metode studi observasional dengan desain cross-sectional yang mengikutsertakan 145 siswa-siswa SD X di Tangerang dan SD Y di Batam. Data dikumpulkan dengan cara wawancara menggunakan kuesioner. Keseimbangan statis diukur dengan metode Standing Stork Test, sedangkan diagnosa pes planus didapatkan dengan metode Wet Foot Print untuk mendapatkan batas lengkung arkus longitudinal medial kaki. Analisis data dilakukan dengan uji Chi-square dengan tingkat kemaknaan yang digunakan 0.05.
HASILDari 145 responden, didapatkan 18 anak (12.4%) memiliki keseimbangan statis yang buruk dan 42 anak (29%) didiagnosa dengan pes planus. Terdapat 18 anak dengan keseimbangan statis yang buruk dengan 16 (88.9%) diantaranya memiliki pes planus. Hasil analisis bivariat menunjukkan terdapat hubungan yang signifikan antara keseimbangan statis dengan pes planus pada anak sekolah dasar (p=0.000).
KESIMPULANTerdapat hubungan signifikan antara pes planus dan keseimbangan statis.
Hubungan antara beban kerja, besaran upah, dan stres kerja pada karyawan PT. HBSP
Authors: Sarifa Sarifa , Wartono Magdalena 
Published: January 2022

LATAR BELAKANG
Perkembangan dunia bisnis yang dinamis tentu berpengaruh terhadap tuntutan produktivitas kerja karyawan. Dalam menjalankan tugas mereka tidak jarang para karyawan mengalami stres kerja yang bisa diakibatkan oleh berbagai faktor antara lain beban kerja dan besaran upah kerja. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara beban kerja, besaran upah dengan stres kerja pada karyawan PT. HBSP.

METODE
Studi cross-sectional pada 95 karyawan PT. HBSP. Data sosiodemografi, lama kerja dan besaran upah dikumpulkan dengan kuesioner. Kategori beban kerja didapatkan dengan menghitung rumus persentase beban kardiovaskuler dan penilaian stres dengan mengunakan survei Health and Safety Executive (HSE). Data yang sudah dikumpulkan selanjutnya dilakukan analisis melalui program SPSS(Statistical Package for the Social Sciences).

HASIL
Responden paling banyak yang berusia 26-45 tahun (62,1%) dan didominasi oleh laki-laki (74,7%). Responden yang telah bekerja <5 tahun adalah 55,8% dan yang sudah menikah sebanyak 69,5%. Sebanyak 78,9% responden tidak menerima besaran upah yang sesuai dengan Upah Minimum Kota. Dalam hal beban kerja, sebanyak 49 responden termasuk kategori diperlukan perbaikan. Mayoritas responden mengalami stres sedang (72,6%).
Tidak terdapat hubungan bermakna antara beban kerja dan kejadian stres kerja (p=0,758),dan terdapat hubungan yang bermakna antara upah terhadap stres kerja pada pekerja PT. HBSP Karawang (p=0,000).
KESIMPULAN
Penelitian ini menunjukkan tidak ada hubungan yang bermakna antara beban kerja dengan kejadian stres kerja tetapi terdapat hubungan yang bermakna antara upah dengan stres kerja pada karyawan PT. HBSP Karawang.
Kekambuhan asma pada perempuan dan berbagai faktor yang memengaruhinya
Authors: Litanto Andriani , Kartini Kartini 
Published: January 2022

Asma merupakan gangguan yang terjadi pada saluran nafas akibat reaksi inflamasi kronik yang menyebabkan peningkatan respon jalan napas dengan gejala mengi, sesak nafas dan dada terasa berat disertai batuk. Gejala asma biasanya terjadi malam hari atau menjelang pagi. Bila asma tidak terkontrol dapat menyebabkan kematian. Sesungguhnya asma tidak dapat sembuh sempurna hanya dapat menghilangkan gejalanya. Setelah pubertas, asma menjadi lebih umum terjadi bahkan dapat semakin parah pada seorang perempuan, dan paling tinggi terjadi pada perempuan dengan menarche dini atau dengan kehamilan multiple. Hal ini menunjukan adanya peran hormon seks dalam patogenesis asma. Namun, pengaruh hormon seks pada patofisiologi asma masih membingungkan dan sulit dibedakan dari usia, obesitas, atopi, maupun paparan lingkungan terkait gender lainnya. Mekanisme yang mendasari perbedaan gender dalam prevalensi asma masih diselidiki tetapi sebagian besar merujuk pada perbedaan hormon dan perbedaan dalam kapasitas paru-paru. Terdapat bukti kuat yang mendukung efek gender pada kejadian dan tingkat keparahan asma. Banyak studi epidemiologis menunjukkan bahwa perempuan berisiko lebih tinggi terkena asma awitan dewasa dan juga menderita penyakit yang lebih parah daripada pria. Perbedaan gender ini tampaknya merupakan produk dari perbedaan biologis dan perbedaan sosiokultural serta lingkungan. Perbedaan biologis terkait jenis kelamin termasuk faktor genetik, dan paru.

METODE
Penelusuran kepustakaan dilakukan melalui Google Scholar dan basis data PubMed dengan kata kunci asma, faktor risiko asma, perempuan, hormon seks, jenis kelamin. Kepustakaan diambil dari jurnal yang membahas kekambuhan asma pada perempuan dan faktor yang memengaruhinya.

KESIMPULAN
Studi epidemiologis menunjukkan bahwa perempuan berisiko lebih tinggi terkena asma awitan dewasa dan juga menderita penyakit yang lebih parah daripada pria. Perbedaan gender ini tampaknya merupakan produk dari perbedaan biologis dan perbedaan sosiokultural serta lingkungan. Perbedaan biologis terkait jenis kelamin termasuk faktor genetik, dan paru.
SUDEP in adults and children
Authors: Cherian Ajith , K P Divya 
Published: January 2022

Sudden unexpected death in epilepsy (SUDEP) represents an important cause of death in patients with epilepsy and it exceeds the expected rate of sudden death in the general population by nearly 24 times. We searched the electronic databases (Cochrane, EMBASE, Scopus, Medline, Pubmed) for studies related to etiology and risk stratification of SUDEP including data on Takotsubo cardiomyopathy (TKC) following seizures resulting in death or near death.: SUDEP is more common among males in the fourth decade of life. Risk for SUDEP is increased by early onset of seizures, low IQ, generalised tonic clonic seizures, nocturnal seizures and seizure frequency. Nonadherance to antiepileptic medications, absence of therapeutic drug level monitoring, presence of neuropathological lesions on imaging and certain subgroups like Dravet syndrome increase its risk. The risk for premature death in patients undergoing temporal lobe resection for drug resistant epilepsy decreased over time but remained above the standard population. Prolonged postictal electroencephalographic suppression was a risk factor for SUDEP in patients with generalised seizures which may indicate a cerebral electrical shutdown. Documented ictal/postictal hypoventilation, laryngeal spasm and cardiac rhythm abnormalities prior to SUDEP may suggest central apnea, neurogenic pulmonary edema, cardiac arrhythmia, or a combination of the above as a cause. Seizure triggered TKC does not seem to play a major role in the pathogenesis of SUDEP.
Guillain barre syndrome and its association with covid-19 infection – A clinical case series
Authors: Karri Madhavi , Jacob Deepak , Ramasamy Balakrishnan , Perumal Santhosh 
Published: January 2022

A novel coronavirus (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARs-CoV-2). This pandemic has been globally alarming in the current period. Several neurological manifestations are reported occurring with the infection. Guillain barre syndrome (GBS) or acute onset inflammatory polyradiculoneuropathy has been among the frequent manifestations observed among them. To know the pattern and outcome of GBS in COVID-19 affected individuals. We have taken six individuals admitted with flaccid quadriparesis in the last two months. All were affected recently by COVID 19 infection, which RT PCR of the nasopharyngeal swab confirmed. The study participants have undergone nerve conduction studies and have been diagnosed with Guillain Barre syndrome using Brighton criteria. We did cerebrospinal fluid (CSF) analysis after admission. We initiated all patients on Intravenous immunoglobulin according to body weight (2g/kg divided over five days). We used the Barthel index score to assess the outcome of the individuals. We observed a mean duration of 18.25 days between the COVID-19 infection and the onset of symptoms. Apart from motor quadriparesis and sensory symptoms being in common, we also noticed cranial nerves and autonomic involvement. We made the diagnosis using the nerve conduction studies and Brighton criteria. After initiating intravenous immunoglobulin, all patients had a good outcome, and quality of life was better after two months of follow up. Guillain Barre syndrome is one of the neurological manifestations of COVID-19 and has a dramatic response with intravenous immunoglobulin and better outcome with treatment.
Phytochemical evaluation and investigation of anti-Fungal activity of turnip top extracts
Authors: Sangray Aarti , Singh Ajeet Pal , Singh Amar Pal 
Published: January 2022

To evaluate the activity of Ethanolic and Aqueous extracts of leaves of against three fungal strains i.e. MTCC3814, and Candida tropicalis MTCC9038 in-vitro.Phytochemical analysis of belonging to family brassicacaea was examined using Ethanolic and Aqueous extracts. Ethanolic and Aqueous extracts of leaves of were investigated individually for antifungal activity by Agar well diffusion method. Both the extracts were tested against selected fungal strains i.e. and to find the inhibitory activities of fungal growth at the dose level of 50 and 100 μg/ml.The phytochemical analysis of ethanolic and aqueous extracts confirmed the presence of phenolic compounds, glycosides, tannins, carbohydrates, proteins, amino acids, tannins, reducing suger, non-reducing suger and inorganic compounds such as calcium, magnesium, iron, carbonate & sulphates. Ethanolic extract of showed considerably high antifungal activities against selected microorganisms than aqueous extract.Although the active components were not isolated but antifungal active plant principles such as flavonoids, glycosides and tannins were observed in the extract. Ethanolic extract of possess effective antifungal properties for selected fungal strains i.e.
Validated high performance thin layer chromatographic analysis of leaves and flower extracts of
Authors: Chakraborty Anup K , Tripathi Harshita , Karole Sarita , Loksh Kavita R 
Published: January 2022

is a significant therapeutic plant has a place with family apocynaceae contains in excess of 70 distinct sorts of chemotherapeutic agents and alkaloids which help in treating different illnesses. For the most part, it is known as Vincarosea, Ammocallisrosea and Lochnerarosea. There are numerous or more than 400 alkaloids present in plant, which are used as flavor, agrochemicals, pharmaceuticals, fragrance, ingredients, food addictives, and pesticides. To develop a validated high performance thin layer chromatographic method for the analysis of leaves and flower extracts of Sample solutions were applied onto the plates with automatic TLC sampler Linomat V (Camag, Muttenz, Switzerland) and were controlled by WinCATS software. Plates were developed in 10 x 10cm twin trough glass chamber (Camag, Muttenz, Switzerland). A CAMAG TLC scanner was used for scanning the TLC plates. Pre-coated silica gel aluminium plates 60F254. For vincristine, simultaneous estimation of vincristine was performed by HPTLC on a silica gel plate using toluene-methanol-diethylamine (8.75: 0.75: 0.5, v/v/v) as the mobile phase. The method was validated as per the ICH guidelines. The Rf value was found to be 0.76 for flower and 0.80 for leaves at 250 nm which shows the presence of vincristin in . In this research paper, a validated HPTLC Method has been developed for the analysis of leaves and flower extracts
Reconstruction of Ipsilateral Femoral and Tibial Bone Defect by 3D Printed Porous Scaffold Without Bone Graft
Authors: Hou Guojin , Liu Bingchuan , Tian Yun , Liu Zhongjun , Zhou Fang 
Published: January 2022

Case:
This study reported the case of a 42-year-old woman with traumatic ipsilateral critical bone defect of right femur and tibia after a motor accident. Three-dimensional (3D) printed porous titanium scaffolds were innovatively used to reconstruct this challenging situation. The initial stability was safe enough for early exercise and partial weight bearing. The 26-month follow-up showed osseous integration of the prosthesis-bone interface with short-term satisfactory clinical result.

Conclusion:
The custom-designed 3D-printed porous scaffold has the potential to become an effective option for reconstructing the segmental irregular-shaped bone defect.
Bilateral Unstable Severe Valgus Slipped Capital Femoral Epiphysis
Authors: Venkatadass K. , Durga Prasad V. , Jain Deepak , Rajasekaran S. 
Published: January 2022

Case:
Bilateral valgus slipped capital femoral epiphysis (SCFE) is a rare condition with few cases reported in the literature. However, there are no reports of bilateral unstable valgus SCFE. We report a unique case of bilateral acute-on-chronic unstable valgus SCFE with severe coxa valga in a 9-year-old girl. She was treated with bilateral capital realignment procedure along with subtrochanteric osteotomy and had a good clinical outcome.

Conclusion:
We hitherto report a rare case of bilateral unstable valgus SCFE which was successfully managed. This report also highlights the importance of the need for additional osteotomies to address the deformity.
A Novel Insertional Achilles Tendon Rupture Repair After Heel Spur Debridement
Authors: Casciato Dominick , Mendicino Robert , Steginsky Brian 
Published: January 2022

Case:
We report a case of a 46-year-old woman who suffered an insertional Achilles tendon rupture secondary to a fall after undergoing retrocalcaneal and Achilles tendon debridements with flexor tendon transfer. Examination revealed posterior ankle pain with insertional Achilles tendon retraction. Treatment options included continued immobilization vs. surgical repair. She underwent Achilles tendon tenodesis to the calcaneus using a combined gastrocsoleus recession and Krackow suture technique.

Conclusion:
At the 1-year follow-up, examination revealed pain-free return to normal function. In the presence of a ruptured Achilles tendon with retraction, this repair provided sufficient lengthening and fixation of the Achilles tendon complex.
Neuroevolutionary reinforcing learning of neural networks
Authors: Bury Y. A. , Samal D. I. 
Published: January 2022

The article presents the results of combining 4 different types of neural network learning: evolutionary, reinforcing, deep and extrapolating. The last two are used as the primary method for reducing the dimension of the input signal of the system and simplifying the process of its training in terms of computational complexity.In the presented work, the neural network structure of the control device of the modeled system is formed in the course of the evolutionary process, taking into account the currently known structural and developmental features of self-learning systems that take place in living nature. This method of constructing it makes it possible to bypass the specific limitations of models created on the basis of recombination of already known topologies of neural networks.
Label-free Quantitative Proteomics Combined With Transcriptomics Revealed the Importance of Cardiac Development in Producing the High Metabolic Capacity of Yellowfin Tuna (Thunnus Albacares)
Authors: Yan Lulu , Guo Jieyun , Zhao Chao , Liu Yong , Wang Pengfei , Fan Sigang , Qiu Lihua , Chen Zuozhi 
Published: January 2022

Abstract
Tuna are commercially important fish throughout the world, and they are renowned for their endothermy, which allows them to maintain elevated temperatures in the oxidative locomotor muscles, viscera, brain, and eyes while occupying cold, productive, high-latitude waters. The endothermic mechanism is supported by a high heart rate and cardiac output, but the genes and proteins that participate in this cardiac function are poorly known. In this study, we combined label-free quantitative proteomics and transcriptomics to investigate the changes in the heart of yellowfin tuna (Thunnus albacares) before and after they developed endothermy. We identified 515,428 transcripts and 3355 protein groups in the hearts of two development stages of yellowfin tuna. Twenty-eight differentially expressed proteins were correlated with differentially expressed genes. The proteins that accelerate energy production were more highly expressed in the hearts of the large yellowfin tuna compared with the small specimens. Moreover, the proteins in the Z-disk, which protect against mechanical damage, were only detected in the hearts of large fish. These results indicate that as yellowfin tuna grow, the heart develops a self-protection strategy to cope with high metabolic rates and high mechanical forces. The differentially expressed proteins related to cardiac function, which are closely associated with striated muscle differentiation, glycosylation, and cardiac myocytes motility, were highly expressed in the larger (endothermic) tuna than that in the smaller (poikilothermic) tuna. Therefore, we suggest that the heart function of yellowfin tuna changes and improves during the transition from poikilothermic tuna (small size, 126 mm < fork length (FL) < 152 mm, 30 g < body weight < 46 g) to endothermic tuna (large size, 207 mm < FL < 235 mm, 170 g < body weight < 200 g). This is the first report of how gene and protein expression levels explain the strong heart function of yellowfin tuna.
A China Healthcare Security Diagnosis Related Groups Script Development Based On R Language
Authors: Zhu Junmin , Fan Yunhai , He Quanhui , Peng Wanglin 
Published: January 2022

Abstract
Background: To develop a set of R scripts that could efficiently and accurately identify the home page information of medical records and perform China Healthcare Security Diagnosis Related Groups (CHS-DRG) simulating grouping.Methods: Based on the CHS-DRG grouping rules, we abstracted the DRG grouping process into a standard algorithm and compiled the R script Z-DRG. The DRG simulating groupings by Z-DRG were compared with the DRG results from the regional CHS-DRG integrated service platform to evaluate the accuracy.Results: The Z-DRG includes one function module (zdrgfun. Rc), one operation module (zdrgpro. R) and one database form (zdrgcodes.RData). The function module set 7 algorithm steps and 8 custom functions. The functions were set for multiple diagnoses, multiple operations, joint diagnosis and operation. Only (17.85±0.11) milliseconds were taken for CHS-DRG simulating grouping of one case. Compared with the regional CHS-DRG results, the accuracy rate was 99.10%. The difference in the number of other diagnoses is the main reason that affected the accuracy.Conclusions: Z-DRG is easy to operate. The CHS-DRG simulating groupings were efficient and accurate. The simulation results could be effectively applied for medical institutions to carry out CHS-DRG grouping prediction and improve the implementation effect of CHS-DRG payment work.
Development of Ternary Concrete Utilizing Agricultural Waste Material
Authors: Kumari Sunita , Singhal Dhirendra , Walia Rinku , Rathee Ajay 
Published: January 2022

Abstract
The present project proposes to utilize rice husk and maize cob husk ash in the cement to mitigate the adverse impact of cement on environment and to enhance the disposal of waste in a sustainable manner. Ternary concrete / MR concrete was prepared by using rise husk and maize cob ash with cement. For the present project, five concrete mixes MR-0 (Control mix), MR-1 (Rice husk ash 10% and MR-2.5%), MR-2 (Rice husk ash 10% and MR-5%), MR-3 (Rice husk ash 10% and MR-2.5%), MR-4 (Rice husk ash 10% and MR-2.5%) were prepared. M35 concrete mix was designed as per IS 10262:2009 for low slump values 0-25mm. The purpose is to find the optimum replacement level of cement in M35 grade ternary concrete for I – Shaped paver blocks.In order to study the effects of these additions, micro-structural and structural properties test of concretes have been conducted. The crystalline properties of control mix and modified concrete are analyzed by Fourier Transform Infrared Spectroscope (FTIR), Scanning Electron Microscopy (SEM), and X-Ray Diffraction (XRD). The results indicated that 10% Rice husk ash and 5% maize cob ash replaced with cement produce a desirable quality of ternary concrete mix having good compressive strength. The results of SEM analysis indicated that the morphology of both concrete were different, showing porous structure at 7 days age and become unsymmetrical with the addition of ashes. After 28 day age, the control mix contained more quantity of ettringite and became denser than ternary concrete. XRD analysis revealed the presence of portlandite in large quantity in controlled mix concrete while MR concrete had the partially hydrated particle of alite.
Glycemic Variability Is Associated With All-Cause Mortality In COVID-19 Patients With ARDSFindings From The COVAS Cohort
Authors: Hartmann Bojan , Verket Marlo , Balfanz Paul , Hartmann Niels-Ulrik , Jacobsen Malte , Brandts Julia , Dreher Michael , Kossack Nils , Häckl Dennis , Marx Nikolaus , Müller-Wieland Dirk 
Published: January 2022

Abstract
There is high mortality among intensive care unit (ICU) patients with acute respiratory distress syndrome (ARDS) caused by coronavirus disease 19 (COVID-19). Important factors for COVID-19 mortality are diabetes status and elevated fasting plasma glucose (FPG). However, the effect of glycemic variability on survival has not been explored in patients with COVID-19 and ARDS. This single-centre cohort-study compared several metrics of daily glycemic variability (DGV) for goodness-of-fit in patients requiring mechanical ventilation due to COVID-19 ARDS in the ICU at University Hospital Aachen, Germany. 106 patients had moderate to severe ARDS (P/F ratio median [IQR]: 112 [87-148] mmHg). Continuous HRs showed a proportional increase in mortality risk with DGV. Multivariable unadjusted and adjusted Cox-models showed a statistically significant difference in mortality for DGV (HR: 1.02, (P)<0.001, LR(P)<0.001; HR: 1.016, (P)=0.001, LR(P)<0.001, respectively). Kaplan-Meier estimators yielded a shorter median survival (25 vs. 87 days) and higher likelihood of death (75% vs. 31%) in patients with DGV ≥ 25.5mg/dl (P<0.0001). High glycemic variability during ICU admission is associated with significant increase in all-cause mortality for patients admitted with COVID-19 ARDS to the ICU. This effect persisted even after adjustment for clinically predetermined confounders, including diabetes, procalcitonin and FPG levels at baseline.