bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of reported food allergies in Brazilian preschoolers living in a small Brazilian city
Authors: da S. Correia José A. , Antunes Adriana Azoubel , Taborda-Barata Luiz , Boechat José Laerte , Sarinho Emanuel Sávio Cavalcanti 
Published: August 2022

Abstract
Introduction
Although the prevalence of allergic diseases, including food allergies, has increased over recent decades, relevant information on this topic is still lacking, particularly in younger children living in small cities.

Objective
To investigate the prevalence of reported food allergies in preschoolers in Limoeiro/Pernambuco, Brazil.

Methods
This was a cross-sectional study with preschoolers. Parents/guardians of all preschoolers enrolled at municipal schools between March and June 2019 (total of 619) were invited to complete a screening questionnaire (total of 619). Another 151 questionnaires were applied on the streets of the town. For positive responses, a second, more detailed and validated questionnaire was completed.

Results
A total of 412 questionnaires were returned, of which, 47 presented a positive response to food allergies and only 29 (7.04%) identified a particular food. The most frequently reported food items were shrimp, mollusks, pork, fruit and milk. Of the 29 who identified foods, 22 responded to the detailed questionnaire, resulting in only 4 (0.97%) positive responses. Of these, two were later discarded through clinical examinations and an open oral provocation test, resulting in a final prevalence of 0.48% of confirmed food allergies.

Conclusion
The prevalence of reported food allergies was lower than that described in previous studies. The most commonly mentioned foods were shrimp, mollusks and pork, with more reports of multiple food allergies, even in children who had never been previously exposed to these possible allergens, which highlights the relevance of perception in reported food allergy studies.
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment
Authors: Zhao Xinyuan , Sun Wenjuan , Guo Bing , Cui Li 
Published: August 2022

AbstractBackgroundPeriodontal ligament stem cells (PDLSCs) are the ideal seed cells for periodontal tissue regeneration. It is well established that persistent inflammation significantly impairs the osteogenic differentiation capability of PDLSCs. Therefore, maintaining PDLSC osteogenic potential under the inflammatory microenvironment is important for treating bone loss in periodontitis. The aim of our study was to explore the potential role of circular RNA BIRC6 (circBIRC6) in regulating osteogenic differentiation of PDLSCs in the inflammatory conditions.MethodsAlkaline phosphatase staining, Alizarin Red staining, quantitative real-time polymerase chain reaction, western blotting and immunofluorescence staining were used to evaluated the effects of circBIRC6 on the osteogenic differentiation of PDLSCs. RNA pull-down and luciferase assays were performed to explore the interaction between circBIRC6 and miR-543. Then, the downstream signaling pathway affected by circBIRC6/miR-543 axis was further investigated.ResultsThe expression level of circBIRC6 was higher in PDLSCs exposed to inflammatory stimulus and in periodontitis tissues compared to the respective controls. Downregulation of circBIRC6 enhanced the osteogenic potential of PDLSCs under the inflammatory conditions, and upregulation of circBIRC6 led to opposite findings. Mechanistically, we found that circBIRC6 modulated PDLSC osteogenic differentiation through sponging miR-543. More importantly, we have demonstrated that circBIRC6/miR-543 axis regulated the mineralization capacity of PDLSCs via PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.ConclusionsIn summary, the expression of miR-543 is significantly increased following circBIRC6 downregulation, leading to inhibition of PTEN and subsequently activation of PI3K/AKT/mTOR signaling pathway. Therefore, targeting circBIRC6 might represent a potential therapeutic strategy for improving bone loss in periodontitis.
Chemical named entity recognition in the texts of scientific publications using the naïve Bayes classifier approach
Authors: Tarasova O. A. , Rudik A. V. , Biziukova N. Yu. , Filimonov D. A. , Poroikov V. V. 
Published: August 2022

Abstract
Motivation
Application of chemical named entity recognition (CNER) algorithms allows retrieval of information from texts about chemical compound identifiers and creates associations with physical–chemical properties and biological activities. Scientific texts represent low-formalized sources of information. Most methods aimed at CNER are based on machine learning approaches, including conditional random fields and deep neural networks. In general, most machine learning approaches require either vector or sparse word representation of texts. Chemical named entities (CNEs) constitute only a small fraction of the whole text, and the datasets used for training are highly imbalanced.

Methods and results
We propose a new method for extracting CNEs from texts based on the naïve Bayes classifier combined with specially developed filters. In contrast to the earlier developed CNER methods, our approach uses the representation of the data as a set of fragments of text (FoTs) with the subsequent preparati`on of a set of multi-n-grams (sequences from one to n symbols) for each FoT. Our approach may provide the recognition of novel CNEs. For CHEMDNER corpus, the values of the sensitivity (recall) was 0.95, precision was 0.74, specificity was 0.88, and balanced accuracy was 0.92 based on five-fold cross validation. We applied the developed algorithm to the extracted CNEs of potential Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) inhibitors. A set of CNEs corresponding to the chemical substances evaluated in the biochemical assays used for the discovery of Mpro inhibitors was retrieved. Manual analysis of the appropriate texts showed that CNEs of potential SARS-CoV-2 Mpro inhibitors were successfully identified by our method.

Conclusion
The obtained results show that the proposed method can be used for filtering out words that are not related to CNEs; therefore, it can be successfully applied to the extraction of CNEs for the purposes of cheminformatics and medicinal chemistry.
Interprofessional collaboration and patient-reported outcomes in inpatient care: a systematic review
Authors: Kaiser Laura , Conrad Susann , Neugebauer Edmund A. M. , Pietsch Barbara , Pieper Dawid 
Published: August 2022

Abstract
Background
Interprofessional collaboration (IPC) is seen as the “gold standard” of comprehensive care, but credible evidence concerning the effects on patient-reported outcomes (PRO) is lacking. The aim of this systematic review is to study the effect of IPC on PRO in inpatient care.

Methods
We systematically searched six electronic databases (PubMed, Web of Science/Social Science Citation Index, CENTRAL (Cochrane Library), Current Contents (LIVIVO), CINAHL, and Embase) for studies published between 1997 and 2021. Additional studies were identified through citation tracking, manually searching the Internet and Google Scholar, and consultation of experts. Risk of bias (RoB) was assessed using the RoB 2 tool for randomized controlled trials (RCTs) and ROBINS-I for non-randomized studies (NRS). The included controlled before-and-after study (CBA) was assessed using both the ROBINS-I and the Effective Practice and Organization of Care (EPOC) quality criteria. Results were synthesized through narrative description, grouping, and thematic analysis of extracted data.

Results
The search yielded 10,213 records, from which 22 studies (16 RCTs, five NRS, and one CBA) fulfilled the inclusion criteria. In all but five studies, RoB was assessed as being high (RoB 2) resp. critical or serious (ROBINS-I). Within these 22 studies, nine inductively derived outcomes were assessed: (i) quality of life, (ii) coping, (iii) functional ability and health status, (iv) psychiatric morbidity, (v) pain, (vi) managing one’s own health care, (vii) treatment success, (viii) satisfaction, and (ix) therapeutic relationship. While some studies do not report effect estimates, and some of the reported effects appear to be imprecisely estimated, the overall results indicate that IPC may affect PRO positively across all outcomes.

Conclusions
Due to high clinical heterogeneity and high RoB, the question whether IPC affects PRO cannot be answered conclusively. Methodically rigorous studies are needed in order to answer the question of effectiveness of IPC.

Systematic review registration
PROSPERO CRD42017073900
Error-constant estimation under the maximum norm for linear Lagrange interpolation
Authors: Galindo Shirley Mae , Ike Koichiro , Liu Xuefeng 
Published: August 2022

AbstractFor the linear Lagrange interpolation over a triangular domain, we propose an efficient algorithm to rigorously evaluate the interpolation error constant under the maximum norm by using the finite-element method (FEM). In solving the optimization problem corresponding to the interpolation error constant, the maximum norm in the constraint condition is the most difficult part to process. To handle this difficulty, a novel method is proposed by combining the orthogonality of the space decomposition using the Fujino–Morley FEM space and the convex-hull property of the Bernstein representation of functions in the FEM space. Numerical results for the lower and upper bounds of the interpolation error constant for triangles of various types are presented to verify the efficiency of the proposed method.
Design of Intrusion Detection System based on Cyborg intelligence for security of Cloud Network Traffic of Smart Cities
Authors: Onyema Edeh Michael , Dalal Surjeet , Romero Carlos Andrés Tavera , Seth Bijeta , Young Praise , Wajid Mohd Anas 
Published: August 2022

AbstractThe Internet of things (IoT) is an important technology that is highly beneficial in establishing smart items, connections and cities. However, there are worries regarding security and privacy vulnerabilities in IoT in which some emerge from numerous sources, including cyberattacks, unsecured networks, data, connections or communication. This paper provides an ensemble intrusion strategy based on Cyborg Intelligence (machine learning and biological intelligence) framework to boost security of IoT enabled networks utilized for network traffic of smart cities. To do this, multiple algorithms such Random Forest, Bayesian network (BN), C5.0, CART and Artificial Neural Network were investigated to determine their usefulness in identifying threats and attacks-botnets in IoT networks based on cyborg intelligence using the KDDcup99 dataset. The results reveal that the AdaBoost ensemble learning based on Cyborg Intelligence Intrusion Detection framework facilitates dissimilar network characteristics with the capacity to swiftly identify different botnet assaults efficiently. The suggested framework has obtained good accuracy, detection rate and a decreased false positive rate in comparison to other standard methodologies. The conclusion of this study would be a valuable complement to the efforts toward protecting IoT-powered networks and the accomplishment of safer smart cities.
Production of cellulosic ethanol and value-added products from corn fiber
Authors: Guo Yingjie , Liu Guodong , Ning Yanchun , Li Xuezhi , Hu Shiyang , Zhao Jian , Qu Yinbo 
Published: August 2022

AbstractCorn fiber, a by-product from the corn processing industry, mainly composed of residual starch, cellulose, and hemicelluloses, is a promising raw material for producing cellulosic ethanol and value-added products due to its abundant reserves and low costs of collection and transportation. Now, several technologies for the production of cellulosic ethanol from corn fiber have been reported, such as the D3MAX process, Cellerate™ process, etc., and part of the technologies have also been used in industrial production in the United States. The ethanol yields range from 64 to 91% of the theoretical maximum, depending on different production processes. Because of the multicomponent of corn fiber and the complex structures highly substituted by a variety of side chains in hemicelluloses of corn fiber, however, there are many challenges in cellulosic ethanol production from corn fiber, such as the low conversion of hemicelluloses to fermentable sugars in enzymatic hydrolysis, high production of inhibitors during pretreatment, etc. Some technologies, including an effective pretreatment process for minimizing inhibitors production and maximizing fermentable sugars recovery, production of enzyme preparations with suitable protein compositions, and the engineering of microorganisms capable of fermenting hexose and pentose in hydrolysates and inhibitors tolerance, etc., need to be further developed. The process integration of cellulosic ethanol and value-added products also needs to be developed to improve the economic benefits of the whole process. This review summarizes the status and progresses of cellulosic ethanol production and potential value-added products from corn fiber and presents some challenges in this field at present.
Successful annuloplasty using the cone-beam computed tomography-assisted radiofrequency thermocoagulation system in a patient with severe vertebral deformity: a case report
Authors: Hagihara Shintaro , Nakagawa Masayuki , Matsubara Kana , Godai Kohei , Kamijima Kenya , Abe Yoichiro 
Published: August 2022

Abstract
Background
Complex anatomical features are challenging for minimally invasive intradiscal therapy owing to insufficient visualization for accurate needle advancement. We report the case of a patient with dysraphic vertebral pathologies who presented with L5/S1 degeneration and was successfully treated with annuloplasty using the cone-beam computed tomography (CBCT)-assisted radiofrequency thermocoagulation system.

Case presentation
A 34-year-old woman presented with a lower back and left radicular pain of L5/S1 discogenic origin, accompanied by spina bifida occulta and lumbosacral transitional vertebra. Radiofrequency annuloplasty was performed to preserve disc height and spinal stability, with real-time CBCT guidance for the congenital and degenerative conditions. The procedure relieved her left lower-extremity pain and magnetic resonance imaging revealed that the L5/S1 disc bulging decreased while the disc height was preserved.

Conclusion
Optimal accessibility of radiofrequency thermocoagulation and effective needle guidance using CBCT significantly improve the success rate of annuloplasty at the L5/S1 degenerative disc with severe vertebral deformity.
Barriers to breastfeeding are shaped by sociocultural context: an exploratory qualitative study in Bangladesh
Authors: Uddin Md. Fakhar , Jabeen Ishrat , Islam Mohammad Ashraful , Rahman Mahfuzur , Chisti Mohammod Jobayer , Ahmed Tahmeed , Sarma Haribondhu 
Published: August 2022

AbstractBackgroundBreastfeeding practice is still not optimum in Bangladesh. Understanding barriers to breastfeeding is needed to prevent harmful practices. This study aimed to understand barriers to breastfeeding among infants and young children in Bangladesh.MethodsThis qualitative study was conducted in five rural sub-districts and one urban slum in Bangladesh. We conceptualized that barriers to breastfeeding can be broadly grouped into individual, society, and system level barriers. We conducted in-depth interviews with 33 breastfeeding mothers and 13 grandmothers of breastfed children (totaln = 46 interviews). We observed 23 of these infants and young children being breastfed. These data were supplemented by 3 focus group discussions held with the children’s fathers. We managed the data using Atlas.ti software and analyzed the data thematically using an inductive approach.ResultsImportant individual-level barriers perceived to influence breastfeeding included misconceptions about the adverse effects of breastfeeding on maternal health, nutrition and physical appearance, and lack of awareness of the value of breastfeeding among family members. Perceived society-level barriers included sociocultural norms, beliefs, and practices such as mother obliged to give more attention on household chores than breastfeeding to become a good housewife and feeding formula milk perceived as a symbol of parents’ financial solvency in the society. System-level barriers included attractive advertisements of breastmilk substitutes, and inadequate facilities and support processes in mothers’ work environments.ConclusionA range of barriers at individual, society and system level have important implications for infant and young children’s breastfeeding practices in Bangladesh. Development of interventions that address the range of barriers that many mothers face is essential to support breastfeeding practices. Potential interventions include strengthening information-giving during interaction between mothers and health workers on breastfeeding techniques, and engaging fathers and other “significant others” in counseling on breastfeeding.
Molecular epidemiology of camel contagious ecthyma in Arero district, Ethiopia
Authors: Diba Bareda , Gelalcha Benti Deresa , Ayele Birhanu , Adane Bedane , Plummer Paul J. 
Published: August 2022

Abstract
Background
While dromedary camels (Camelus dromedarius) were traditionally believed to be resistant to most livestock diseases, research has demonstrated that they are susceptible to a large number of infectious agents. Based on the clinical appearance of typical lesions, camel contagious ecthyma, caused by a Parapoxvirus, is thought to be one of the most common viral diseases of dromedary camels in Ethiopia.

Methods
A cross-sectional study was conducted from November 2013 to April 2014 in Arero district of Borana Zone, Oromia Regional State of Ethiopia to investigate the epidemiological aspect of camel contagious ecthyma and molecularly identify the causative agent. A polymerase chain reaction based on B2L gene-specific primers of Parapoxvirus was used for confirmatory diagnosis of the disease from camels showing suspected clinical signs of Parapoxvirus infection.

Results
The majority (87%) of camel owners reported the occurrence of camel contagious ecthyma outbreaks in their herds in the past year (a year preceding the start of the study). The overall morbidity and mortality rates attributed to camel contagious ecthyma were 20% (95% CI 11–36%) and 6.3% (95% CI 5.2–7.6%), respectively. Camel calves had higher odds of becoming affected by the disease than adults [OR = 3.44 (95% CI 2.29–4.09)] and the difference was statistically significant. The disease has a marked seasonality with most of the cases occurring during the rainy season. Acacia trees significantly contribute to virus dissemination by damaging the lips of browsing camels. Confirmatory diagnosis of the suspected cases using conventional polymerase chain reaction generated the expected amplification product of 1200 bp for one of the samples.

Conclusions
This study confirms the presence and importance of camel contagious ecthyma in Ethiopia and establishes the basis for further research.
Misuse of analysis of variance in African biomedical journals: a call for more vigilance
Authors: Abubakar Bilyaminu , Uthman Yaaqub Abiodun , Jatau Abubakar Ibrahim , Danbatta Abubakar , Nuhu Hafsat Nasidi , Mustapha Mohammed 
Published: August 2022

Abstract
Background
Misuse of analysis of variance alongside other statistical methods has been an important topic of discussion in many scientific gatherings. Although misuse of analysis of variance is of global concern, its prevalence in African-based biomedical journals has raised concerns among colleagues.

Methods
We sampled the current issues/last published issues of all African biomedical journals aggregated in an African journal aggregator. We scanned through all the journals’ sample articles in the journal aggregator and retrieved articles that either applied analysis of variance or were supposed to use the test.

Results
Our results show that 126 articles of the total 1789 sampled articles employed analysis of variance test for analysis. Of these, 99 (78.6%) articles used the analysis of variance test correctly, while 27 (21.4%) misused the test. Not stating the type of analysis of variance test employed for analysis was the most prevalent misuse of analysis of variance test.

Conclusions
In overall, the study demonstrated that misuse of analysis of variance test is prevalent in African biomedical journals. Therefore, all stakeholders (medical schools, reviewers, journal editors) need to do more to nip it in the bud.
Intestine and spleen microbiota composition in healthy and diseased tilapia
Authors: Ofek Tamir , Lalzar Maya , Izhaki Ido , Halpern Malka 
Published: August 2022

AbstractSymbiotic bacteria within the gut microbiome of various organisms, including fish, provide the host with several functions that improve the immune system. Although the spleen plays an important role in the modulation of immune responses, the role of spleen microbiota in shaping the immune system is unclear. Our study aimed at understanding the relationship between fish health and microbiota composition in the intestine and spleen. Our model organism was the hybrid tilapia (Oreochromis aureus × Oreochromis niloticus). We sampled intestine and spleen from healthy and diseased adult tilapia and determined their microbiota composition by sequencing the 16S rRNA gene. Significant differences were found between the intestine and the spleen microbiota composition of healthy compared to diseased fish as well as between intestines and spleens of fish with the same health condition. The microbiota diversity of healthy fish compared to diseased fish was significantly different as well. In the intestine of healthy fish,Cetobacteriumwas the most abundant genus whileMycoplasmawas the most abundant genus in the spleen.Vibriowas the most abundant genus in the intestine and spleen of diseased fish. Moreover, it seems that there is a co-infection interaction betweenVibrioandAeromonas, which was reflected in the spleen of diseased fish. WhileVibrio, AeromonasandStreptococcuswere the probable pathogens in the diseased fish, the role ofMycoplasmaas a pathogen of cultured hybrid tilapia remains uncertain. We conclude that the intestine and spleen microbiota composition is strongly related to the health condition of the fish.
Co-overexpression of self-renewal markers SALL4 and HIWI is correlated with depth of tumor invasion and metastasis in colorectal cancer
Authors: Forghanifard Mohammad Mahdi , Salehi Somayeh 
Published: August 2022

Abstract
Background
SALL4 and HIWI are involved in the maintenance of self-renewal capacity of stem cells. Several scrutinizes have demonstrated that SALL4 and HIWI play a key role in cancer development. However, the correlation between these genes regarding different clinicopathological features of patients with colorectal cancer (CRC) is still unclear.

Methods
The expression of SALL4 and HIWI in different clinicopathological features of 46 CRC patients was analyzed using relative comparative real-time PCR.

Results
mRNA expression levels of SALL4 and HIWI genes were significantly correlated with each other in CRC (P = 0.013, Pearson correlation = 0.364). HIWI expression was notably increased in tumors with overexpression of SALL4 in comparison with other samples. This correlation was significant in non-metastatic CRCs compared to the metastatic tumors and in invaded tumors to the serosa (T3/T4) in comparison with non-invaded tumors (T1/T2).

Conclusions
Based on the significant association of SALL4 and HIWI in different indices of CRC poor prognosis, it may be concluded that simultaneous expression of these genes is notably contributed to the growth and development of the disease, and therefore, their co-overexpression may be considered for prognosis of aggressive CRCs.