bluuebunny/crossref_metadata_2025_split huggingface dataset:
Milk yield and composition in dairy goats fed extruded flaxseed or a high-palmitic acid fat supplement
Authors: Lévesque Janie , Dion Stéphanie , Rico Daniel E. , Brassard Marie-Ève , Gervais Rachel , Chouinard P. Yvan 
Published: December 2022

AbstractWe compared the potential of dietary lipid supplements of different fatty acid compositions to affect milk performance when early lactation dairy goats were fed a high-concentrate diet. Thirty Alpine goats at 23 ± 5 d in milk were allocated to 1 of 10 blocks according to parity and milk fat concentration. Within each block, goats were randomly assigned to receive, during a period of 41 d, either CONT) a basal diet with a forage to concentrate ratio of 45:55, used as control, or PALM) the basal diet + 2% of a palmitic acid-enriched fat supplement, or FLAX) the basal diet + 7% of extruded flaxseed. Body weight, dry matter intake and milk yield were not different between treatments. As compared with CONT, goats fed PALM and FLAX had a greater milk fat concentration. Moreover, milk fat yield was numerically (but non-significantly) greater with PALM than with CONT. Milk fat from goats receiving PALM had a greater concentration of 16:0 as compared with CONT and FLAX, whereas a greater concentration of cis-9, cis-12, cis-15 18:3 was observed when goats were fed FLAX as compared with CONT and PALM. Under the conditions of the current experiment, dietary fat supplementation had only minor impacts on the yield of major milk constituents, with the exception of a modest increase in fat yield when goats were fed PALM. The impact of a greater concentration of 16:0 in milk fat of goats receiving this feed ingredient on the nutritive value of dairy products remains to be determined.
On the nature of morphological alternations in Archaic Chinese and their relevance to morphosyntax
Authors: Jacques Guillaume 
Published: December 2022

AbstractWhile sound glosses from the Six Dynasties and early Tang provide direct evidence for morphological alternations in Archaic Chinese, studies on the syntax of this language generally disregard these data. This neglect is due in part to perceived unreliability of these sound glosses. In this paper, I first argue that the arguments against their reliability do not stand scrutiny, and that they are not a simple philological curiosity, but have the potential to enrich studies on Archaic Chinese syntax, and plead for more collaboration between syntacticians and historical phonologists.
Is the assumption of waning of treatment effect applied consistently across NICE technology appraisals? A case-study focusing on disease-modifying therapies for treatment of multiple sclerosis
Authors: Armoiry Xavier , Wang-Steverding Xia , Connock Martin , Grove Amy , Clarke Aileen , Arun Tarunya , Counsell Carl , Auguste Peter 
Published: December 2022

Abstract

Objectives
Whether the effects of therapies may wane over time is a matter of debate, especially when considering their long-term cost-effectiveness. Here, we examined how the assumption of the waning of treatment effect was applied across the National Institute for Health and Care Excellence (NICE) appraisals for disease-modifying therapies (DMTs) used in multiple sclerosis.

Methods
We undertook a document analysis following a search of the NICE website. The inclusion criteria of the study were as follows: all publicly available documents related to completed appraisals for DMTs (period: January 2000 to July 2021). The exclusion criteria of the study were as follows: all documents that did not meet the inclusion criteria, especially pertaining to drugs used in other disease areas. We extracted information about the waning of treatment effect assumption as considered by companies, assessment groups, and appraisal committees, and we analyzed trends over time.

Results
We reviewed fifteen appraisals that reported guidance on sixteen DMTs. Irrespective of the drugs’ mechanism of action or their pharmaceutical nature, there was substantial variation in the modalities when the assumption of waning was implemented. We noted the recent preference to use all-cause discontinuation as a proxy. This heterogeneity did not appear to affect acceptance of the DMTs (all but one were recommended for use across the National Health System (NHS)).

Conclusions
Modeling the long-term effect of therapies is challenging, especially given the limited follow-up duration of related trials. This generates recurrent debates on the presence of waning of treatment efficacy and heterogeneity across appraisals. More refined recommendations obtained by consensus among stakeholders could help to achieve greater consistency in decision making.
Incorporating environmental and sustainability considerations into health technology assessment and clinical and public health guidelines: a scoping review
Authors: Pinho-Gomes Ana-Catarina , Yoo Seo-Hyun , Allen Alexander , Maiden Hannah , Shah Koonal , Toolan Michael 
Published: December 2022

AbstractHealthcare systems account for a substantial proportion of global carbon emissions and contribute to wider environmental degradation. This scoping review aimed to summarize the evidence currently available on incorporation of environmental and sustainability considerations into health technology assessments (HTAs) and guidelines to support the National In stitute for Health and Care Excellence and analogous bodies in other jurisdictions developing theirown methods and processes. Overall, 7,653 articles were identified, of which 24 were included in this review and split into three key areas – HTA (10 studies), healthcare guidelines (4 studies), and food and dietary guidelines (10 studies). Methodological reviews discussed the pros and cons of different approaches to integrate environmental considerations into HTAs, including adjustments to conventional cost-utility analysis (CUA), cost–benefit analysis, and multicriteria decision analysis. The case studies illustrated the challenges of putting this into practice, such as lack of disaggregated data to evaluate the impact of single technologies and difficulty in conducting thorough life cycle assessments that consider the full environmental effects. Evidence was scant on the incorporation of environmental impacts in clinical practice and public health guidelines. Food and dietary guidelines used adapted CUA based on life cycle assessments, simulation modeling, and qualitative judgments made by expert panels. There is uncertainty on how HTA and guideline committees will handle trade-offs between health and environment, especially when balancing environmental harms that fall largely on society with health benefits for individuals. Further research is warranted to enable integration of environmental considerations into HTA and clinical and public health guidelines.
Sign advantage: Both children and adults’ spatial expressions in sign are more informative than those in speech and gestures combined
Authors: KARADÖLLER Dilay Z. , SÜMER Beyza , ÜNAL Ercenur , ÖZYÜREK Aslı 
Published: December 2022

AbstractExpressing Left-Right relations is challenging for speaking-children. Yet, this challenge was absent for signing-children, possibly due to iconicity in the visual-spatial modality of expression. We investigate whether there is also a modality advantage when speaking-children’s co-speech gestures are considered. Eight-year-old child and adult hearing monolingual Turkish speakers and deaf signers of Turkish-Sign-Language described pictures of objects in various spatial relations. Descriptions were coded for informativeness in speech, sign, and speech-gesture combinations for encoding Left-Right relations. The use of co-speech gestures increased the informativeness of speakers’ spatial expressions compared to speech-only. This pattern was more prominent for children than adults. However, signing-adults and children were more informative than child and adult speakers even when co-speech gestures were considered. Thus, both speaking- and signing-children benefit from iconic expressions in visual modality. Finally, in each modality, children were less informative than adults, pointing to the challenge of this spatial domain in development.
Concurrent validity and reliability of at-home teleneuropsychological evaluations among people with and without HIV
Authors: Kohli Maulika , Fisher Arin , Sun-Suslow Ni , Heaton Anne , Dawson Matthew S. , Marquie Jennifer , Franklin Donald R. , Marquine Maria , Iudicello Jennifer E. , Heaton Robert K. , Moore David J. 
Published: December 2022

AbstractObjective:To determine the reliability of teleneuropsychological (TNP) compared to in-person assessments (IPA) in people with HIV (PWH) and without HIV (HIV−).Methods:Participants included 80 PWH (Mage = 58.7, SDage = 11.0) and 23 HIV− (Mage = 61.9, SDage = 16.7). Participants completed two comprehensive neuropsychological IPA before one TNP during the COVID-19 pandemic (March–December 2020). The neuropsychological tests included: Hopkins Verbal Learning Test-Revised (HVLT-R Total and Delayed Recall), Controlled Oral Word Association Test (COWAT; FAS-English or PMR-Spanish), Animal Fluency, Action (Verb) Fluency, Wechsler Adult Intelligence Scale 3rd Edition (WAIS-III) Symbol Search and Letter Number Sequencing, Stroop Color and Word Test, Paced Auditory Serial Addition Test (Channel 1), and Boston Naming Test. Total raw scores and sub-scores were used in analyses. In the total sample and by HIV status, test-retest reliability and performance-level differences were evaluated between the two consecutive IPA (i.e., IPA1 and IPA2), and mean in-person scores (IPA-M), and TNP.Results:There were statistically significant test-retest correlations between IPA1 and IPA2 (r or ρ = .603–.883, ps < .001), and between IPA-M and TNP (r or ρ = .622–.958, ps < .001). In the total sample, significantly lower test-retest scores were found between IPA-M and TNP on the COWAT (PMR), Stroop Color and Word Test, WAIS-III Letter Number Sequencing, and HVLT-R Total Recall (ps < .05). Results were similar in PWH only.Conclusions:This study demonstrates reliability of TNP in PWH and HIV−. TNP assessments are a promising way to improve access to traditional neuropsychological services and maintain ongoing clinical research studies during the COVID-19 pandemic.
The Italian consensus conference on psychological therapies for anxiety and depressive disorders: findings and recommendations
Authors: Barbato Angelo , Bottesi Gioia , Biondi Massimo , Corbo Mariangela , de Girolamo Giovanni , Favaretto Gerardo , Garattini Silvio , Migone Paolo , Moderato Paolo , Monzani Emiliano , Veltro Franco , Sanavio Ezio 
Published: December 2022

Abstract
A Consensus Conference of clinicians, researchers, public health specialists and users was convened in Italy to review efficacy, effectiveness, treatment appropriateness and access to care for anxiety and depression, and to consider the role of psychological therapies. Expert opinion was sought concerning identification of people requiring psychological therapies according to levels of symptom severity matched to corresponding levels of treatment intensity, suitability of psychological therapies for subclinical anxiety or depression, definition of a minimum level of information on evidence-based psychotherapies to be provided by university medical and psychology courses, initiatives to raise awareness among potential users and decision makers on the role and effectiveness of psychological therapies in healthcare. The expert jury concluded that a number of psychological therapy models endorsed by most authoritative guidelines are supported by research showing their effectiveness at least equal to the drugs used in common mental disorders (CMDs). Such therapies are under-represented in the Italian public health system, leading many people to resort to the private sector, resulting in unacceptable wealth discrimination. The difficulty of accessing psychological treatments often entails the use of drug therapies in cases where they are not indicated. Starting from these assumptions, the experts recommended the promotion of better and timely recognition of anxiety and depressive disorders and their classification in terms of symptom intensity and functional impairment, differentiating subthreshold mood swings from clinical forms, to foster outcome studies of psychotherapies in CMDs in Italy, to introduce a stepped care model structured according to levels of intensity of treatment, based on wellbeing support strategies in nonmedical contexts for subthreshold situations, self-help, support and psychoeducation as frontline interventions in mild clinical forms, evidence-based psychotherapies in moderate and severe forms, with the option of combining psychological treatment and appropriate drug therapy in the most severe cases.
Preclinical and clinical evidence on the approach-avoidance conflict evaluation as an integrative tool for psychopathology
Authors: Rusconi F. , Rossetti M. G. , Forastieri C. , Tritto V. , Bellani M. , Battaglioli E. 
Published: December 2022

Abstract
The approach-avoidance conflict (AAC), i.e. the competing tendencies to undertake goal-directed actions or to withdraw from everyday life challenges, stands at the basis of humans' existence defining behavioural and personality domains. Gray's Reinforcement Sensitivity Theory posits that a stable bias toward approach or avoidance represents a psychopathological trait associated with excessive sensitivity to reward or punishment. Optogenetic studies in rodents and imaging studies in humans associated with cross-species AAC paradigms granted new emphasis to the hippocampus as a hub of behavioural inhibition. For instance, recent functional neuroimaging studies show that functional brain activity in the human hippocampus correlates with threat perception and seems to underlie passive avoidance. Therefore, our commentary aims to (i) discuss the inhibitory role of the hippocampus in approach-related behaviours and (ii) promote the integration of functional neuroimaging with cross-species AAC paradigms as a means of diagnostic, therapeutic, follow up and prognosis refinement in psychiatric populations.
Global Gridded Ionospheric Electron Density Derivation During 2006–2016 by Assimilating COSMIC TEC and Its Validation
Authors: He Jianhui , Yue Xinan , Astafyeva Elvira , Le Huijun , Ren Zhipeng , Pedatella Nicholas M. , Ding Feng , Wei Yong 
Published: December 2022

AbstractThe long‐term accurate specification of the Earth's ionospheric states is crucial to scientific research and applications in the space weather community. In the current work, a global monthly mean three‐dimensional (3‐D) ionospheric electron density product has been obtained during one solar cycle from 2006 to 2016. Specifically, an accurate 3‐D product is reconstructed monthly by assimilating the Constellation Observing System for Meteorology, Ionosphere and Climate slant total electron content (TEC) into an empirical background model via the Kalman filter data assimilation algorithm. The outputs of the results have spatial resolutions of 2° in latitude, 5° in longitude, and 20 km in height, and temporal resolution of 1 hr in universal time. The accuracy and reliability of the results are systematically validated by the critical frequency at the F2 layer from global ionosonde stations, the in situ electron density from the CHAllenging Minisatellite Payload Planar Langmuir Probe, the TEC from the Massachusetts Institute of Technology, and Gravity Recovery and Climate Experiment. We found that the products agree well with the independent observations. Some well‐known ionospheric climatological patterns, including the solar and seasonal variation, annual asymmetry, the Weddell Sea Anomaly, and the longitudinal wave structure, can be well illustrated. The advantages of the products are its 3‐D and gridded electron density and continuous one solar cycle time series (2006–2016). It is useful to study the spatial‐temporal variations in ionospheric states from seasons to decades, which can also be used as the background parameters for atmospheric and ionospheric‐related scientific research and applications.
Equatorial Pacific pCO2 Interannual Variability in CMIP6 Models
Authors: Wong Suki C. K. , McKinley Galen A. , Seager Richard 
Published: December 2022

AbstractThe El Niño‐Southern Oscillation (ENSO) in the equatorial Pacific is the dominant mode of global air‐sea carbon dioxide (CO2) flux interannual variability (IAV). Air‐sea CO2 fluxes are driven by the difference between atmospheric and surface ocean pCO2, with variability of the latter driving flux variability. Previous studies found that models in Coupled Model Intercomparison Project Phase 5 (CMIP5) failed to reproduce the observed ENSO‐related pattern of CO2 fluxes and had weak pCO2 IAV, which were explained by both weak upwelling IAV and weak mean vertical dissolved inorganic carbon (DIC) gradients. We assess whether the latest generation of CMIP6 models can reproduce equatorial Pacific pCO2 IAV by validating models against observations‐based data products. We decompose pCO2 IAV into thermally and non‐thermally driven anomalies to examine the balance between these competing anomalies, which explain the total pCO2 IAV. The majority of CMIP6 models underestimate pCO2 IAV, while they overestimate sea surface temperature IAV. Insufficient compensation of non‐thermal pCO2 to thermal pCO2 IAV in models results in weak total pCO2 IAV. We compare the relative strengths of the vertical transport of temperature and DIC and evaluate their contributions to thermal and non‐thermal pCO2 anomalies. Model‐to‐observations‐based product comparisons reveal that modeled mean vertical DIC gradients are biased weak relative to their mean vertical temperature gradients, but upwelling acting on these gradients is insufficient to explain the relative magnitudes of thermal and non‐thermal pCO2 anomalies.
Targeting PEA3 transcription factors to mitigate small cell lung cancer progression
Authors: Shia David W. , Choi WooSuk , Vijayaraj Preethi , Vuong Valarie , Sandlin Jenna M. , Lu Michelle M. , Aziz Adam , Marin Caliope , Aros Cody J. , Sen Chandani , Durra Abdo , Lund Andrew J. , Purkayastha Arunima , Rickabaugh Tammy M. , Graeber Thomas G. , Gomperts Brigitte N. 
Published: December 2022

AbstractSmall cell lung cancer (SCLC) remains a lethal disease with a dismal overall survival rate of 6% despite promising responses to upfront combination chemotherapy. The key drivers of such rapid mortality include early metastatic dissemination in the natural course of the disease and the near guaranteed emergence of chemoresistant disease. Here, we found that we could model the regression and relapse seen in clinical SCLC in vitro. We utilized time-course resolved RNA-sequencing to globally profile transcriptome changes as SCLC cells responded to a combination of cisplatin and etoposide—the standard-of-care in SCLC. Comparisons across time points demonstrated a distinct transient transcriptional state resembling embryonic diapause. Differential gene expression analysis revealed that expression of the PEA3 transcription factors ETV4 and ETV5 were transiently upregulated in the surviving fraction of cells which we determined to be necessary for efficient clonogenic expansion following chemotherapy. The FGFR-PEA3 signaling axis guided the identification of a pan-FGFR inhibitor demonstrating in vitro and in vivo efficacy in delaying progression following combination chemotherapy, observed inhibition of phosphorylation of the FGFR adaptor FRS2 and corresponding downstream MAPK and PI3K-Akt signaling pathways. Taken together, these data nominate PEA3 transcription factors as key mediators of relapse progression in SCLC and identify a clinically actionable small molecule candidate for delaying relapse of SCLC.
Striatal connectopic maps link to functional domains across psychiatric disorders
Authors: Mulders Peter C. R. , van Eijndhoven Philip F. P. , van Oort Jasper , Oldehinkel Marianne , Duyser Fleur A. , Kist Josina D. , Collard Rose M. , Vrijsen Janna N. , Haak Koen V. , Beckmann Christian F. , Tendolkar Indira , Marquand Andre F. 
Published: December 2022

AbstractTransdiagnostic approaches to psychiatry have significant potential in overcoming the limitations of conventional diagnostic paradigms. However, while frameworks such as the Research Domain Criteria have garnered significant enthusiasm among researchers and clinicians from a theoretical angle, examples of how such an approach might translate in practice to understand the biological mechanisms underlying complex patterns of behaviors in realistic and heterogeneous populations have been sparse. In a richly phenotyped clinical sample (n = 186) specifically designed to capture the complex nature of heterogeneity and comorbidity within- and between stress- and neurodevelopmental disorders, we use exploratory factor analysis on a wide range of clinical questionnaires to identify four stable functional domains that transcend diagnosis and relate to negative valence, cognition, social functioning and inhibition/arousal before replicating them in an independent dataset (n = 188). We then use connectopic mapping to map inter-individual variation in fine-grained topographical organization of functional connectivity in the striatum—a central hub in motor, cognitive, affective and reward-related brain circuits—and use multivariate machine learning (canonical correlation analysis) to show that these individualized topographic representations predict transdiagnostic functional domains out of sample (r = 0.20, p = 0.026). We propose that investigating psychiatric symptoms across disorders is a promising path to linking them to underlying biology, and can help bridge the gap between neuroscience and clinical psychiatry.
Consensus opinion from an international group of experts on measurable residual disease in hairy cell leukemia
Authors: Ravandi Farhad , Kreitman Robert J. , Tiacci Enrico , Andritsos Leslie , Banerji Versha , Barrientos Jacqueline C. , Bhat Seema A. , Blachly James S. , Broccoli Alessandro , Call Timothy , Chihara Dai , Dearden Claire , Demeter Judit , Dietrich Sasha , Else Monica , Epperla Narendranath , Falini Brunangelo , Forconi Francesco , Gladstone Douglas E. , Gozzetti Alessandro , Iyengar Sunil , Johnston James B. , Jorgensen Jeffrey , Juliusson Gunnar , Lauria Francesco , Lozanski Gerard , Parikh Sameer A. , Park Jae H. , Polliack Aaron , Quest Graeme , Robak Tadeusz , Rogers Kerry A. , Saven Alan , Seymour John F. , Tadmor Tamar , Tallman Martin S. , Tam Constantine S. , Thompson Philip A. , Troussard Xavier , Zent Clive S. , Zenz Thorsten , Zinzani Pier Luigi , Wörmann Bernhard , Rai Kanti , Grever Michael 
Published: December 2022

AbstractA significant body of literature has been generated related to the detection of measurable residual disease (MRD) at the time of achieving complete remission (CR) in patients with hairy cell leukemia (HCL). However, due to the indolent nature of the disease as well as reports suggesting long-term survival in patients treated with a single course of a nucleoside analog albeit without evidence of cure, the merits of detection of MRD and attempts to eradicate it have been debated. Studies utilizing novel strategies in the relapse setting have demonstrated the utility of achieving CR with undetectable MRD (uMRD) in prolonging the duration of remission. Several assays including immunohistochemical analysis of bone marrow specimens, multi-parameter flow cytometry and molecular assays to detect the mutant BRAF V600E gene or the consensus primer for the immunoglobulin heavy chain gene (IGH) rearrangement have been utilized with few comparative studies. Here we provide a consensus report on the available data, the potential merits of MRD assessment in the front-line and relapse settings and recommendations on future role of MRD assessment in HCL.