bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clustering students’ writing behaviors using keystroke logging: a learning analytic approach in EFL writing
Authors: Talebinamvar Mobina , Zarrabi Forooq 
Published: February 2022

AbstractFeedback is an essential component of learning environments. However, providing feedback in populated classes can be challenging for teachers. On the one hand, it is unlikely that a single kind of feedback works for all students considering the heterogeneous nature of their needs. On the other hand, delivering personalized feedback is infeasible and time-consuming. Available automated feedback systems have helped solve the problem to some extent. However, they can provide personalized feedback only after a draft is submitted. To help struggling students during the writing process, we can use machine learning to cluster students who benefit the same from feedback using keystroke logs. We can apply the results in automated feedback systems that provide process feedback. In this study, we aim to find homogeneous student profiles based on their writing process indicators. We use fourteen process indicators to find clusters in the data set. We used these measures in a four-stage analysis, including (a) data preprocessing, (b) dimensionality reduction, (c) clustering, and (d) the analysis of the writing quality. Clustering techniques identified five different profiles: Strategic planners, Rapid writers, Emerging planners, Average writers, and Low-performing writers. We further validated the emerged profiles by comparing them concerning students' writing quality. The present work broadens our knowledge of how students interact with writing tasks and addresses how variations in writing behaviors lead to qualitatively different products. We discuss the theoretical underpinnings and potentials of finding profiles of students during writing in higher education.
A strategic reset: micro-credentials for higher education leaders
Authors: McGreal Rory , Olcott Don 
Published: February 2022

AbstractThis article provides university leaders an introduction to the emerging micro-credentials field, including a snapshot of the global landscape. Despite the accelerated interest in micro-credentials, this article also raises a fundamental strategic question for leaders at the outset: Are micro-credentials right for our university? Part I discusses the basic elements of mcro-credentials, definitions, types of micro-credentials, and affordances and barriers and various providers of micro-credentials. Part II presents a snapshot of what is happening on the global playing field and the challenges inherent in trying to standardise micro-credentials globally. The final section of the article provides some general observations by the authors, lessons from practice, and brief example of how institutions may implement a strategic reset using micro-credentials. The authors close by emphasising micro-credentials are not a panacea for resolving institutional challenges and they are unlikely to become a major revenue enhancement. They may provide strategic value in their integration with other major institutional initiatives.
Enhanced-view totally extraperitoneal repair in a patient with incisional hernia after robot-assisted laparoscopic radical prostatectomy: a case report
Authors: Honma Shusaku , Tanino Keisuke , Kumode Takashi , Mizuno Ryosuke , Matsui Yugo , Yao Siyuan , Murakami Teppei , Kan Takatsugu , Nakajima Sanae , Harada Takehisa 
Published: February 2022

Abstract
Background
Although laparoscopic incisional hernia repair, especially laparoscopic intraperitoneal onlay mesh, is a widely used technique, it can cause serious complications, including mesh erosion, adhesive bowel obstruction, and chronic pain. The enhanced-view totally extraperitoneal (eTEP) technique has been reported to prevent such complications by placing the mesh in the retrorectus space. Here, we report the case of a patient with post-robot-assisted laparoscopic radical prostatectomy (RARP) incisional hernia repaired using the eTEP technique.

Case presentation
A 67-year-old man, who underwent RARP for prostate cancer 4 years ago developed an incisional hernia. Abdominal computed tomography showed the presence of an epigastric incisional hernia measuring 4 cm long and 3.7 cm wide. We performed an eTEP repair. We closed the hernia defect using a 0 barbed suture and placed a self-gripping mesh measuring 20 cm long and 15 cm wide in the developed retrorectus space with no fixation. There were no postoperative complications, and the patient was discharged on postoperative day 2.

Conclusions
eTEP repair is considered an extremely effective surgical treatment option for incisional hernias because of its few resulting postoperative mesh-and-tacker-related complications.
Rare monomorphic epithelial intestinal T-cell lymphoma of the stomach with a giant gastric perforation rescued by liver-covering sutures followed by a total gastrectomy and lateral hepatectomy: a case report
Authors: Muramoto Keiji , Kaida Sachiko , Miyake Toru , Nishimura Rie , Kito Katsuyuki , Shiohara Masanori , Kushima Ryoji , Shimizu Tomoharu , Tani Masaji 
Published: February 2022

Abstract
Background
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), a type of peripheral T-cell lymphoma, rarely involves the stomach as the primary organ. Advanced MEITL, for which there is currently no established treatment, causes gastrointestinal perforations and is characterized by a poor response to chemotherapy.

Case presentation
A 69-year-old man had undergone chemotherapy for MEITL of the whole stomach. He subsequently developed acute abdominal pain, and computed tomography revealed a giant perforation in the anterior gastric wall adjacent to the lateral segment of the liver. The perforation was rescued through closure with liver-covering sutures. Thereafter, a total gastrectomy and a left hepatectomy were performed and he recovered enough to tolerate oral intake. However, despite ongoing chemotherapy, the patient died 83 days after the gastric perforation (10 months after being diagnosed with the lymphoma) owing to rapid progression of the MEITL.

Conclusion
In the rare case of a giant gastric perforation after chemotherapy for gastric MEITL, rescue is possible through liver-covering sutures followed by a total gastrectomy and lateral hepatectomy.
Joint association of meal frequency and diet quality with metabolic syndrome in Iranian adults
Authors: Azizi Neda , Shab-Bidar Sakineh , Bazshahi Elham , Lesani Azadeh , Javanbakht Mohammad Hassan , Djafarian Kurosh 
Published: February 2022

AbstractBackgroundMetabolic syndrome (MetS) is a common complication that has been shown in various studies to be related to the frequency and timing of eating. We aimed to evaluate the relationship between meal timing and frequency with diet quality and prevalence of MetS.Study designCross-sectional.MethodsWe analyzed data from 850 adults (20 to 59 years) and divided the participants into different categories in terms of frequency of eating occasions (EO) (5 ≥ , 6–7 and 7 <), meal (2 ≥ and 3) and snack (2 ≥ , 3 and 4 ≤) in a day. Daily food consumption was assessed using the structured three 24-h recalls. The quality of diet we calculated using the food quality score (FQS). Metabolic syndrome was defined based on the guidelines of the national cholesterol education program adult treatment panel III (ATP III). The covariates-adjusted relationships between exposures and outcomes were investigated using a logistic regression test and two-way ANOVA.ResultsThe overall prevalence of MetS in participants was 34.2%. The average FQS was 28.0. Increased frequency of EOs and snacks was related to the higher prevalence of MetS ((OR, 1.72; 95% CI, 1.24, 2.37;P < 0.01) and (OR, 1.34; 95% CI, 1.07, 1.68; P, 0.01), respectively). The adjusted mean of FQS was not significantly different between the EO as well as meals and snack categories. The joint association of EO frequency and snack frequency with diet quality showed a higher chance of having MetS ( (OR, 2.36; 95% CI, 1.19, 4.66; P, 0.01 and (OR, 1.68; 95% CI, 1.06, 2.68; P,0.02), respectively). Also, we observed a higher mean of high density level cholesterol in people with the highest FQS and lowest EO frequency (P,0.02).ConclusionOur findings suggest that the EO and snack frequency may be associated with the higher chance of MetS. We also found when the frequency of EO increases, the beneficial associations of the diet quality were overshadowed. To confirm our findings, well designed randomised clinical trials are needed.
Identification of a chromatin regulator signature and potential candidate drugs for bladder cancer
Authors: Zhu Ke , Liu Xiaoqiang , Deng Wen , Wang Gongxian , Fu Bin 
Published: February 2022

Abstract
Background
Bladder cancer (BLCA) is a malignant tumor with a dismay outcome. Increasing evidence has confirmed that chromatin regulators (CRs) are involved in cancer progression. Therefore, we aimed to explore the function and prognostic value of CRs in BLCA patients.

Methods
Chromatin regulators (CRs) were acquired from the previous top research. The mRNA expression and clinical information were downloaded from TCGA and GEO datasets. Cox regression analysis and least absolute shrinkage and selection operator (LASSO) regression analysis were performed to select the prognostic gene and construct the risk model for predicting outcome in BLCA. The Kaplan-Meier analysis was used to assess the prognosis between high- and low-risk groups. We also investigated the drug sensitivity difference between high- and low-risk groups. CMAP dataset was performed to screen the small molecule drugs for treatment.

Results
We successfully constructed and validated an 11 CRs-based model for predicting the prognosis of patients with BLCA. Moreover, we also found 11 CRs-based model was an independent prognostic factor. Functional analysis suggested that CRs were mainly enriched in cancer-related signaling pathways. The CR-based model was also correlated with immune cells infiltration and immune checkpoint. Patients in the high-risk group were more sensitive to several drugs, such as mitomycin C, gemcitabine, cisplatin. Eight small molecule drugs could be beneficial to treatment for BLCA patients.

Conclusion:
In conclusion, our study provided novel insights into the function of CRs in BLCA. We identified a reliable prognostic biomarker for the survival of patients with BLCA.
Forensic evaluation of pedestrian injuries by FORTIS system and its significance for technical analysis of traffic accidents performed using simulation programs
Authors: Morochovič Radoslav , Mandelík Ján , Vémola Aleš , Obrátilová Alena 
Published: February 2022

Abstract
Background
Currently, simulation programs are used for a technical analysis of accidents including pedestrians as they provide a great amount of data on the physical parameters of the pedestrian’s body movement and its contacts with the vehicle or the road. In order to be able to make use of the presented options, it is necessary to obtain additional information about detected injuries from forensic doctors in a way utilizable for technical experts.

Methods
This study includes the results of 250 traffic accidents and approximately 200 real accidents, as well as 255 simulations. The evaluations were based on the investigation of circumstances, accompanying documentation, autopsy findings, photo documentation, and the results of additional expert examinations. We further proceeded in line with the complete autopsy findings in accordance with the requirements of the international classification of diseases.

Results
Previous practice has shown that the modified forensic system FORTIS, due to its capability to parametrize through localization using the PC Fortis © program, is an important tool to supplement verbal descriptions and localizations of injuries that have been used so far.

Conclusions
The FORTIS system is a usable and universal means of supplementing verbal medical descriptions for the needs of traffic accident analysts with a scoring system of a high informative value. This, in combination with a video simulation of contacts with a pedestrian’s body during a collision and with values of physical parameters from simulation programs, makes it possible to significantly increase the value of evidence for the needs of the police and courts.
Proptosis secondary to a solitary plasmacytoma of the sphenoid bone: a case report on a rare skull base tumour
Authors: Seetahal-Maraj Panduranga , Knight Patrick , Ramnarine Narindra 
Published: February 2022

AbstractBackgroundPlasmacytomas of the skull base are not commonly encountered in clinical practice, with few reported cases in the literature. They form part of the spectrum of plasma cell neoplasms and are classified as a solitary bone plasmacytoma if arising from the sphenoid bone. Its radiographic appearance can lead to misdiagnosis as one of the tumours that are more frequently seen in the skull base, especially meningiomas. Due to the risk of evolution into multiple myeloma, accurate diagnosis is essential.Case presentationA 56-year-old male presented to the emergency department with rapid proptosis and worsening vision in his right eye for one week’s duration. Imaging studies revealed an extra-axial right sphenoid bone tumour with invasion into the temporalis muscle and orbit, leading to significant proptosis. Tumour debulking was done, but there was no improvement in vision postoperatively. Final histology was consistent with a plasmacytoma. The patient was referred to the oncologist for radiation therapy, but subsequently developed further lesions consistent with multiple myeloma.ConclusionsPlasmacytomas need to be considered in the differential diagnosis of skull base tumours. Due to their excellent response to radiation, these patients should have early oncology intervention to prevent irreversible neurological deficits.
320 cardiac MDCT angiography in preoperative assessment of TOF and its variants: Does it worth it?
Authors: Elreweny Eman Abdel Sadek Taha , Dawoud Mohammed Mahmoud , Mahmoud Alaa Basiouni Said , Amin Mohamed A. , Zaitoun Hossam Mohammed Abdel Hafiz 
Published: February 2022

Abstract
Background
Tetralogy of Fallot is the most common cyanotic congenital heart disease encountering a large spectrum of anatomical presentations with differing surgical approaches, and long-term outcomes ranging from ventricular septal defect with limited aortic overriding and mild pulmonary obstruction to a critical form of VSD and pulmonary atresia. TOF variants include PA/VSD, TOF/CAVC, TOF/DORV and TOF with absent pulmonary valve. Also, it may be accompanied with many associated intracardiac and extracardiac anomalies that may be of value when imaging and planning the surgical procedure.

Results
Our study included 22 cases of classic TOF, 18 with PA/VSD (12 were of type A, 5 were of type B and 1 was of type C), 3 with TOF/CAVC and 7 TOF/DORV. Sub-valvular RVOTO was detected in 94% of patients. A statistically significant difference was depicted between Echocardiography and MDCT in detecting supravalvular RVOTO, however no statistically significant difference was found in sub-valvular and valvular RVOTO detection. MDCT could efficiently characterize pulmonary arterial tree with statistically significant difference between both Echocardiography and MDCT in assessment of main, right and left pulmonary arteries with P value = 0.036,0.014 and 0.023 respectively. With calculation of Mc-Goon ratio in all patients, it was favorable (> 1.2) in 33 patients (66%). MDCT entailed 19 patients with PDA versus 15 depicted by Echocardiography and 25 MAPCAs per 11patients compared 8 MAPCAs per 7 patients detected by Echocardiography. Right sided aortic arch was found in 10 patients and 24 patients showed abnormal branching pattern. Coronary artery abnormalities were identified in eight patients. MDCT showed 100% sensitivity and 100% specificity in depicting aortic, coronary and other associated extracardiac vascular anomalies.

Conclusion
MDCT offers comprehensive anatomical assessment of TOF, and its variants providing superiority over echocardiography and comparable results to cardiac catherization with 100% sensitivity and specificity in evaluation of associated extracardiac vascular anomalies as well as pulmonary arteries characterization. It is worth using MDCT routinely in combination with echocardiography for the preoperative assessment of TOF and its variants representing a less invasive option than conventional catherization with lower radiation exposure.
Resting state fMRI brain mapping in pediatric supratentorial brain tumors
Authors: Anwar Ahmed , Radwan Ahmed , Zaky Iman , El Ayadi Moatasem , Youssef Ayda 
Published: February 2022

Abstract
Background
Functional mapping of eloquent brain areas is crucial for preoperative planning in patients with brain tumors. Resting state functional MRI (rs-fMRI) allows the localization of functional brain areas without the need for task performance, making it well-suited for the pediatric population. In this study the independent component analysis (ICA) rs-fMRI functional mapping results are reported in a group of 22 pediatric patients with supratentorial brain tumors. Additionally, the functional connectivity (FC) maps of the sensori-motor network (SMN) obtained using ICA and seed-based analysis (SBA) are compared.

Results
Different resting state networks (RSNs) were extracted using ICA with varying levels of sensitivity, notably, the SMN was identified in 100% of patients, followed by the Default mode network (DMN) (91%) and Language networks (80%). Additionally, FC maps of the SMN extracted by SBA were more extensive (mean volume = 25,288.36 mm3, standard deviation = 13,364.36 mm3) than those found on ICA (mean volume = 13,403.27 mm3, standard deviation = 9755.661 mm3). This was confirmed by statistical analysis using a Wilcoxon signed rank t test at p < 0.01.

Conclusions
Results clearly demonstrate the successful applicability of rs-fMRI for localizing different functional brain networks in the preoperative assessment of brain areas, and thus represent a further step in the integration of computational radiology research in a clinical setting.
Image encryption using spatial nonlinear optics
Authors: Hou Junfeng , Situ Guohai 
Published: February 2022

AbstractOptical technologies have been widely used in information security owing to its parallel and high-speed processing capability. However, the most critical problem with current optical encryption techniques is that the cyphertext is linearly related with the plaintext, leading to the possibility that one can crack the system by solving a set of linear equations with only two cyphertext from the same encryption machine. Many efforts have been taken in the last decade to resolve the linearity issue, but none of these offers a true nonlinear solution. Inspired by the recent advance in spatial nonlinear optics, here we demonstrate a true nonlinear optical encryption technique. We show that, owing to the self-phase modulation effect of the photorefractive crystal, the proposed nonlinear optical image encryption technique is robust against the known plaintext attack based on phase retrieval. This opens up a new avenue for optical encryption in the spatial nonlinear domain.
Effects of the WRITE Symptoms Interventions on Symptoms and Quality of Life Among Patients With Recurrent Ovarian Cancers: An NRG Oncology/GOG Study (GOG-0259)
Authors: Donovan Heidi S. , Sereika Susan M. , Wenzel Lari B. , Edwards Robert P. , Knapp Judith E. , Hughes Susan H. , Roberge Mary C. , Thomas Teresa H. , Klein Sara Jo , Spring Michael B. , Nolte Susan , Landrum Lisa M. , Casey A. Catherine , Mutch David G. , DeBernardo Robert L. , Muller Carolyn Y. , Sullivan Stephanie A. , Ward Sandra E. 
Published: February 2022

PURPOSE GOG-259 was a 3-arm randomized controlled trial of two web-based symptom management interventions for patients with recurrent ovarian cancer. Primary aims were to compare the efficacy of the nurse-guided (Nurse-WRITE) and self-directed (SD-WRITE) interventions to Enhanced Usual Care (EUC) in improving symptoms (burden and controllability) and quality of life (QOL). METHODS Patients with recurrent or persistent ovarian, fallopian, or primary peritoneal cancer with 3+ symptoms were eligible for the study. Participants completed baseline (BL) surveys (symptom burden and controllability and QOL) before random assignment. WRITE interventions lasted 8 weeks to develop symptom management plans for three target symptoms. All women received EUC: monthly online symptom assessment with provider reports; online resources; and every 2-week e-mails. Outcomes were evaluated at 8 and 12 weeks after BL. Repeated-measures modeling with linear contrasts evaluated group by time effects on symptom burden, controllability, and QOL, controlling for key covariates. RESULTS Participants (N = 497) reported mean age of 59.3 ± 9.2 years. At BL, 84% were receiving chemotherapy and reported a mean of 14.2 ± 4.9 concurrent symptoms, most commonly fatigue, constipation, and peripheral neuropathy. Symptom burden and QOL improved significantly over time ( P < .001) for all three groups. A group by time interaction ( P < .001) for symptom controllability was noted whereby both WRITE intervention groups had similar improvements from BL to 8 and 12 weeks, whereas EUC did not improve over time. CONCLUSION Both WRITE Intervention groups showed significantly greater improvements in symptom controllability from BL to 8 and BL to 12 weeks compared with EUC. There were no significant differences between Nurse-WRITE and SD-WRITE. SD-WRITE has potential as a scalable intervention for a future implementation study.
Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions
Authors: Kolli Aditya R. , Semren Tanja Zivkovic , Bovard David , Majeed Shoaib , van der Toorn Marco , Scheuner Sophie , Guy Philippe A. , Kuczaj Arkadiusz , Mazurov Anatoly , Frentzel Stefan , Calvino-Martin Florian , Ivanov Nikolai V. , O’Mullane John , Peitsch Manuel C. , Hoeng Julia 
Published: February 2022

AbstractIn vitro screening for pharmacological activity of existing drugs showed chloroquine and hydroxychloroquine to be effective against severe acute respiratory syndrome coronavirus 2. Oral administration of these compounds to obtain desired pulmonary exposures resulted in dose-limiting systemic toxicity in humans. However, pulmonary drug delivery enables direct and rapid administration to obtain higher local tissue concentrations in target tissue. In this work, inhalable formulations for thermal aerosolization of chloroquine and hydroxychloroquine were developed, and their physicochemical properties were characterized. Thermal aerosolization of 40 mg/mL chloroquine and 100 mg/mL hydroxychloroquine formulations delivered respirable aerosol particle sizes with 0.15 and 0.33 mg per 55 mL puff, respectively. In vitro toxicity was evaluated by exposing primary human bronchial epithelial cells to aerosol generated from Vitrocell. An in vitro exposure to 7.24 μg of chloroquine or 7.99 μg hydroxychloroquine showed no significant changes in cilia beating, transepithelial electrical resistance, and cell viability. The pharmacokinetics of inhaled aerosols was predicted by developing a physiologically based pharmacokinetic model that included a detailed species-specific respiratory tract physiology and lysosomal trapping. Based on the model predictions, inhaling emitted doses comprising 1.5 mg of chloroquine or 3.3 mg hydroxychloroquine three times a day may yield therapeutically effective concentrations in the lung. Inhalation of higher doses further increased effective concentrations in the lung while maintaining lower systemic concentrations. Given the theoretically favorable risk/benefit ratio, the clinical significance for pulmonary delivery of aerosolized chloroquine and hydroxychloroquine to treat COVID-19 needs to be established in rigorous safety and efficacy studies.