bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organisational and individual readiness for change to respectful maternity care practice and associated factors in Ibadan, Nigeria: a cross-sectional survey
Authors: Esan Oluwaseun Taiwo , Maswime Salome , Blaauw Duane 
Published: November 2022

ObjectivesThis study assessed health providers’ organisational and individual readiness for change to respectful maternity care (RMC) practice and their associated factors in Ibadan Metropolis, Nigeria.DesignA cross-sectional survey using standardised structured instruments adapted from the literature.SettingNine public health facilities in Ibadan Metropolis, Nigeria, 1 December 2019–31 May 2020.Participants212 health providers selected via a two-stage cluster sampling.OutcomesOrganisational readiness for change to RMC (ORCRMC) and individual readiness for change to RMC (IRCRMC) scales had a maximum score of 5. Multiple linear regression was used to identify factors influencing IRCRMCand ORCRMC.We evaluated previously identified predictors of readiness for change (change valence, informational assessments on resource adequacy, core self-evaluation and job satisfaction) and proposed others (workplace characteristics, awareness of mistreatment during childbirth, perceptions of women’s rights and resource availability to implement RMC). Data were adjusted for clustering and analysed using Stata V.15.ResultsThe providers’ mean age was 44.0±9.9 years with 15.4±9.9 years of work experience. They scored high on awareness of women’s mistreatment (3.9±0.5) and women’s perceived rights during childbirth (3.9±0.5). They had high ORCRMC(4.1±0.9) and IRCRMC(4.2±0.6), both weakly but positively correlated (r=0.407, 95% CI: 0.288 to 0.514, p<0.001). Providers also had high change valence (4.5±0.8) but lower perceptions of resource availability (2.7±0.7) and adequacy for implementation (3.3±0.7). Higher provider change valence and informational assessments were associated with significantly increased IRCRMC(β=0.40, 95% CI: 0.11 to 0.70, p=0.015 and β=0.07, 95% CI: 0.01 to 0.13, p=0.032, respectively), and also with significantly increased ORCRMC(β=0.47, 95% CI: 0.21 to 0.74, p=0.004 and β=0.43, 95% CI: 0.22 to 0.63, p=0.002, respectively). Longer years of work experience (β=0.08, 95% CI: 0.01 to 0.2, p=0.024), providers’ monthly income (β=0.08, 95% CI: 0.02 to 0.15, p=0.021) and the health facility of practice were associated with significantly increased ORCRMC.ConclusionThe health providers studied valued a change to RMC and believed that both they and their facilities were ready for the change to RMC practice.
Serial high-sensitivity cardiac troponin testing for the diagnosis of myocardial infarction: a scoping review
Authors: Ohtake Hirotaka , Terasawa Teruhiko , Zhelev Zhivko , Iwata Mitsunaga , Rogers Morwenna , Peters Jaime L , Hyde Chris 
Published: November 2022

ObjectivesWe aimed to assess the diversity and practices of existing studies on several assays and algorithms for serial measurements of high-sensitivity cardiac troponin (hs-cTn) for risk stratification and the diagnosis of myocardial infarction (MI) and 30-day outcomes in patients suspected of having non-ST-segment elevation MI (NSTEMI).MethodsWe searched multiple databases including MEDLINE, EMBASE, Science Citation Index, the Cochrane Database of Systematic Reviews and the CENTRAL databases for studies published between January 2006 and November 2021. Studies that assessed the diagnostic accuracy of serial hs-cTn testing in patients suspected of having NSTEMI in the emergency department (ED) were eligible. Data were analysed using the scoping review method.ResultsWe included 86 publications, mainly from research centres in Europe, North America and Australasia. Two hs-cTn assays, manufactured by Abbott (43/86) and Roche (53/86), dominated the evaluations. The studies most commonly measured the concentrations of hs-cTn at two time points, at presentation and a few hours thereafter, to assess the two-strata or three-strata algorithm for diagnosing or ruling out MI. Although data from 83 studies (97%) were prospectively collected, 0%–90% of the eligible patients were excluded from the analysis due to missing blood samples or the lack of a final diagnosis in 53 studies (62%) that reported relevant data. Only 19 studies (22%) reported on head-to-head comparisons of alternative assays.ConclusionEvidence on the accuracy of serial hs-cTn testing was largely derived from selected research institutions and relied on two specific assays. The proportions of the eligible patients excluded from the study raise concerns about directly applying the study findings to clinical practice in frontline EDs.PROSPERO registration numberCRD42018106379.
Utilisation of cervical cancer screening and factors associated with screening utilisation among women aged 30–49 years in Mertule Mariam Town, East Gojjam Zone, Ethiopia, in 2021: a cross-sectional survey
Authors: Tesfaw Kinfemichael , Kindie Walelign , Mulatu Kebadnew , Bogale Eyob Ketema 
Published: November 2022

ObjectiveTo assess the practice of cervical cancer screening and its associated factors among women aged 30–49 years.DesignCommunity-based cross-sectional survey.SettingMertule Mariam Town, Northwest Ethiopia, 1 May–20 June 2021.ParticipantsWomen aged 30–49 years who were living in the study area were eligible for inclusion. A systematic random sampling technique was used to select study participants. A total of 488 respondents participated in the study. Data were collected by using interviewer-administered structured questionnaires. Data were entered into EpiData V.3.1 and then exported to SPSS V.25 for analysis. Bivariable and multivariable logistic regression analyses were done.Outcome measuresPrevalence of cervical cancer screening and factors associated with screening utilisation.ResultsThe prevalence of cervical cancer screening was found to be 14.1%. Age (≤16 years) at first sexual intercourse (adjusted OR 14.89, 95% CI 6.21 to 35.74), history of sexually transmitted disease (11.65, 4.56 to 29.78), having multiple sexual partners (11.65, 4.56 to 29.78), having good knowledge about cervical cancer screening (4.72, 2.33 to 9.56) and having a family history of cervical cancer (4.72, 2.33 to 9.56) were statistically significantly associated factors for utilisation of cervical cancer screening.ConclusionUtilisation of cervical cancer screening was low in Northwest Ethiopia. Educational status, age at first sexual intercourse, history of multiple sexual partners, sexually transmitted disease, family history of cervical cancer and knowledge about cervical cancer screening were significant factors for utilisation of cervical cancer screening.
Scrutinizing the 95–100 GeV di-tau excess in the top associated process
Authors: Iguro Syuhei , Kitahara Teppei , Omura Yuji 
Published: November 2022

AbstractRecently, the CMS collaboration has reported a di-tau excess with a local significance of 2.6–3.1$$\sigma $$
σ
where the invariant mass is $$m_{\tau \tau } =95$$

m

τ
τ

=
95

–100 GeV. This excess can be interpreted as a light scalar boson that couples to the third generation fermions, particularly top and $$\tau $$
τ
. Based on the simplest model that can account for the CMS di-tau excess, we evaluate experimental sensitivities to the additional light resonance, using the results reported by the ATLAS collaboration. We see that a search for the top-quark associated production of the SM Higgs boson that decays into $$\tau {\bar{\tau }}$$

τ

τ

¯

sets a strong model-independent limit. We also find that the CP-even scalar interpretation of the light resonance is excluded by the ATLAS results, while the CP-odd interpretation is not.
Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
Authors: Patterson Jesse C. , Varkaris Andreas , Croucher Peter J.P. , Ridinger Maya , Dalrymple Susan , Nouri Mannan , Xie Fang , Varmeh Shohreh , Jonas Oliver , Whitman Matthew A. , Chen Sen , Rashed Saleh , Makusha Lovemore , Luo Jun , Isaacs John T. , Erlander Mark G. , Einstein David J. , Balk Steven P. , Yaffe Michael B. 
Published: November 2022

Abstract

Abiraterone is a standard treatment for metastatic castrate-resistant prostate cancer (mCRPC) that slows disease progression by abrogating androgen synthesis and antagonizing the androgen receptor (AR). Here we report that inhibitors of the mitotic regulator polo-like kinase-1 (Plk1), including the clinically active third-generation Plk1 inhibitor onvansertib, synergizes with abiraterone in vitro and in vivo to kill a subset of cancer cells from a wide variety of tumor types in an androgen-independent manner. Gene-expression analysis identified an AR-independent synergy-specific gene set signature upregulated upon abiraterone treatment that is dominated by pathways related to mitosis and the mitotic spindle. Abiraterone treatment alone caused defects in mitotic spindle orientation, failure of complete chromosome condensation, and improper cell division independently of its effects on AR signaling. These effects, although mild following abiraterone monotherapy, resulted in profound sensitization to the antimitotic effects of Plk1 inhibition, leading to spindle assembly checkpoint-dependent mitotic cancer cell death and entosis. In a murine patient-derived xenograft model of abiraterone-resistant metastatic castration-resistant prostate cancer (mCRPC), combined onvansertib and abiraterone resulted in enhanced mitotic arrest and dramatic inhibition of tumor cell growth compared with either agent alone. Overall, this work establishes a mechanistic basis for the phase II clinical trial (NCT03414034) testing combined onvansertib and abiraterone in mCRPC patients and indicates this combination may have broad utility for cancer treatment.

Significance:
Abiraterone treatment induces mitotic defects that sensitize cancer cells to Plk1 inhibition, revealing an AR-independent mechanism for this synergistic combination that is applicable to a variety of cancer types.
Alterations to Sphingomyelin Metabolism Affect Hemostasis and Thrombosis
Authors: Wang Jue , Keshava Shiva , Das Kaushik , Kolesnick Richard , Jiang Xian-Cheng , Pendurthi Usha R. , Rao L. Vijaya Mohan 
Published: November 2022

Background:
Our recent studies suggest that sphingomyelin levels in the plasma membrane influence TF (tissue factor) procoagulant activity. The current study was performed to investigate how alterations to sphingomyelin metabolic pathway would affect TF procoagulant activity and thereby affect hemostatic and thrombotic processes.

Methods:
Macrophages and endothelial cells were transfected with specific siRNAs or infected with adenoviral vectors to alter sphingomyelin levels in the membrane. TF activity was measured in factor X activation assay. Saphenous vein incision–induced bleeding and the inferior vena cava ligation–induced flow restriction mouse models were used to evaluate hemostasis and thrombosis, respectively.

Results:

Overexpression of SMS (sphingomyelin synthase) 1 or SMS2 in human monocyte-derived macrophages suppresses ATP-stimulated TF procoagulant activity, whereas silencing SMS1 or SMS2 increases the basal cell surface TF activity to the same level as of ATP-decrypted TF activity. Consistent with the concept that sphingomyelin metabolism influences TF procoagulant activity, silencing of acid sphingomyelinase or neutral sphingomyelinase 2 or 3 attenuates ATP-induced enhanced TF procoagulant activity in macrophages and endothelial cells. Niemann-Pick disease fibroblasts with a higher concentration of sphingomyelin exhibited lower TF activity compared with wild-type fibroblasts. In vivo studies revealed that LPS+ATP-induced TF activity and thrombin generation were attenuated in ASMase
−
/−
mice, while their levels were increased in SMS2
−/−
mice. Further studies revealed that acid sphingomyelinase deficiency leads to impaired hemostasis, whereas SMS2 deficiency increases thrombotic risk.

Conclusions:
Overall, our data indicate that alterations in sphingomyelin metabolism would influence TF procoagulant activity and affect hemostatic and thrombotic processes.
Disguised Disciplinary Sanctions and Public Service in Jordanian and French Law
Authors: A’amar Omar Mahmoud , Alhendi Noor Issa 
Published: November 2022

Abstract
Disguised disciplinary sanctions are methods used by public administrators or decision-makers to punish a public servant despite the latter not having violated regulations or laws. Instead, such punishment is motivated by personal resentments. The administration may impose arbitrary decisions on their employees while claiming that said decisions serve the public interest, hiding their true intentions. This study employs a descriptive-analytical method to shed light on the position of the Jordanian and French administrative judicial authorities on disguised disciplinary sanctions. The study considers and compares the relevant laws and jurisprudence of judicial authorities in Jordan and France; it further determines the role of these authorities in revealing disguised sanctions absent a specified list of disciplinary violations in the Civil Service Regulations in both jurisdictions.
A Temporal Gauge Quality Control Algorithm as a Method for Identifying Potential Instrumentation Malfunctions
Authors: Martinaitis Steven M. , Lincoln Scott , Schlotzhauer David , Cocks Stephen B. , Zhang Jian 
Published: November 2022

Abstract
There are multiple reasons as to why a precipitation gauge would report erroneous observations. Systematic errors relating to the measuring apparatus or resulting from observational limitations due to environmental factors (e.g., wind-induced undercatch or wetting losses) can be quantified and potentially corrected within a gauge dataset. Other challenges can arise from instrumentation malfunctions, such as clogging, poor siting, and software issues. Instrumentation malfunctions are challenging to quantify as most gauge quality control (QC) schemes focus on the current observation and not on whether the gauge has an inherent issue that would likely require maintenance of the gauge. This study focuses on the development of a temporal QC scheme to identify the likelihood of an instrumentation malfunction through the examination of hourly gauge observations and associated QC designations. The analyzed gauge performance resulted in a temporal QC classification using one of three categories: GOOD, SUSP, and BAD. The temporal QC scheme also accounts for and provides an additional designation when a significant percentage of gauge observations and associated hourly QC were influenced by meteorological factors (e.g., the inability to properly measure winter precipitation). Findings showed a consistent percentage of gauges that were classified as BAD through the running 7-day (2.9%) and 30-day (4.4%) analyses. Verification of select gauges demonstrated how the temporal QC algorithm captured different forms of instrumental-based systematic errors that influenced gauge observations. Results from this study can benefit the identification of degraded performance at gauge sites prior to scheduled routine maintenance.

Significance Statement
This study proposes a scheme that quality controls rain gauges based on its performance over a running history of hourly observational data and quality control flags to identify gauges that likely have an instrumentation malfunction. Findings from this study show the potential of identifying gauges that are impacted by issues such as clogging, software errors, and poor gauge siting. This study also highlights the challenges of distinguishing between erroneous gauge observations based on an instrumentation malfunction versus erroneous observations that were the result of an environmental factor that influence the gauge observation or its quality control classification, such as winter precipitation or virga.
Automatic detection of the mental foramen for estimating mandibular cortical width in dental panoramic radiographs: the seventh survey of the Tromsø Study (Tromsø7) in 2015–2016
Authors: Edvardsen Isak Paasche , Teterina Anna , Johansen Thomas , Myhre Jonas Nordhaug , Godtliebsen Fred , Bolstad Napat Limchaichana 
Published: November 2022

Objective To apply deep learning to a data set of dental panoramic radiographs to detect the mental foramen for automatic assessment of the mandibular cortical width. Methods Data from the seventh survey of the Tromsø Study (Tromsø7) were used. The data set contained 5197 randomly chosen dental panoramic radiographs. Four pretrained object detectors were tested. We randomly chose 80% of the data for training and 20% for testing. Models were trained using GeForce RTX 2080 Ti with 11 GB GPU memory (NVIDIA Corporation, Santa Clara, CA, USA). Python programming language version 3.7 was used for analysis. Results The EfficientDet-D0 model showed the highest average precision of 0.30. When the threshold to regard a prediction as correct (intersection over union) was set to 0.5, the average precision was 0.79. The RetinaNet model achieved the lowest average precision of 0.23, and the precision was 0.64 when the intersection over union was set to 0.5. The procedure to estimate mandibular cortical width showed acceptable results. Of 100 random images, the algorithm produced an output 93 times, 20 of which were not visually satisfactory. Conclusions EfficientDet-D0 effectively detected the mental foramen. Methods for estimating bone quality are important in radiology and require further development.
Natural History of Degenerative Hip Abductor Tendon Lesions
Authors: Schenk Pascal , Dimitriou Dimitris , Rahm Stefan , Zimmermann Stefan M. , Finsterwald Michael , Higashigaito Kai , Sutter Reto , Zingg Patrick O. 
Published: November 2022

Background: The best treatment of degenerative hip abductor tendon lesions remains largely unknown, as the natural course of the disease has not yet been reported. The aim of the present study was to investigate the natural history of symptomatic degenerative hip abductor lesions. Hypothesis: Nonoperatively treated hip abductor lesions progress over time, resulting in refractory hip pain and low functional outcomes. Study Design: Case series (prognosis); Level of evidence, 4. Methods: Consecutive patients with greater trochanteric pain syndrome and degenerative changes on magnetic resonance imaging (MRI) of the symptomatic hip were included. Bilateral hip MRI scans and a clinical examination were performed at a minimum follow-up of 36 months to study the type and location of hip abductor lesion. Progression of a lesion was defined as a more severe lesion as compared with the initial MRI results or if the lesion extended to another, initially not involved, trochanteric facet. The muscle’s fatty infiltration (FI) was also described. Results: From 106 patients identified, 58 patients (64 hips) aged 66 ± 14 years (mean ± SD) agreed to return to the clinic for follow-up MRI and met the inclusion criteria. At a mean 71-month follow-up, an overall 34% (22/64) of lesions had progressed over time: from trochanteric bursitis to tendinopathy (9/64, 14%) or partial tear (5/64, 8%), from tendinopathy to partial tear (4/64, 6%), from a partial to complete tear (3/64, 4.5%), and with 1 complete tear (1/64, 1.5%) extending to another trochanteric facet. Interestingly, 90% of partial tears remained stable or transformed into a scar. Although patients with a progressive lesion experienced more trochanteric pain (visual analog scale, 4.6 vs 2.8; P = .001), the functional outcomes were comparable with patients with a stable lesion. The majority of hips with a partial tear (64%) demonstrated a progression of gluteus minimus FI from a median grade of 1 to 2, whereas only 1 hip (3%) progressed from grade 2 to 3. Only 3 hips (9%) with a partial tear had a progression of gluteus medius FI, which did not differ significantly from the contralateral unaffected side. Conclusion: Nonoperative treatment might be a valid long-term option for degenerative hip abductor lesions, especially for partial tears, which demonstrated a low risk of clinically relevant progression or muscle FI and similar clinical outcomes to those reported in the literature for operatively treated hip abductor tendon lesions.
Preoperative Risk Factors for Subsequent Ipsilateral ACL Revision Surgery After an ACL Restoration Procedure
Authors: Sanborn Ryan M. , Badger Gary J. , Fleming Braden C. , Kiapour Ata M. ,   The BEAR Trial Team, Fadale Paul D. , Hulstyn Michael J. , Owens Brett D. , Proffen Benedikt , Sant Nicholas , Portilla Gabriela , Freiberger Christina , Henderson Rachael , Barnett Samuel , Costa Meggin , Chrostek Cynthia , Ecklund Kirsten , Micheli Lyle J. , Murray Martha M. , Yen Yi-Meng , Kramer Dennis E. 
Published: November 2022

Background: Anterior cruciate ligament (ACL) revision surgery is challenging for both patients and surgeons. Understanding the risk factors for failure after bridge-enhanced ACL restoration (BEAR) may help with patient selection for ACL restoration versus ACL reconstruction. Purpose: To identify the preoperative risk factors for ACL revision surgery within the first 2 years after BEAR. Study Design: Case-control study; Level of evidence, 3. Methods: Data from the prospective BEAR I, II, and III trials were used to determine the preoperative risk factors for ACL revision surgery. All patients with a complete ACL tear (aged 13-47 years, depending on the trial), who met all other inclusion/exclusion criteria and underwent a primary BEAR procedure within 30 to 50 days from the injury (dependent on the trial), were included. Demographic data (age, sex, body mass index), baseline patient-reported outcomes (International Knee Documentation Committee [IKDC] subjective score, Marx activity score), preoperative imaging results (ACL stump length, notch size, tibial slope), and intraoperative findings (knee hyperextension, meniscal status) were evaluated to determine their contribution to the risk of ipsilateral ACL revision surgery. Results: A total of 123 patients, with a median age of 17.6 years (interquartile range, 16-23 years), including 67 (54%) female patients, met study criteria. Overall, 18 (15%) patients required ACL revision surgery in the first 2 years after the BEAR procedure. On bivariate analyses, younger age ( P = .011), having a contact injury at the time of the initial tear ( P = .048), and increased medial tibial slope (MTS; P = .029) were associated with a higher risk of ipsilateral revision surgery. Multivariable logistic regression analyses identified 2 independent predictors of revision: patient age and MTS. The odds of ipsilateral revision surgery were decreased by 32% for each 1-year increase in age (odds ratio, 0.684 [95% CI, 0.517-0.905]; P = .008) and increased by 28% for each 1° increase in MTS (odds ratio, 1.280 [95% CI, 1.024-1.601]; P = .030). Sex, baseline IKDC or Marx score, knee hyperextension, and meniscal status were not significant predictors of revision. Conclusion: Younger age and higher MTS were predictors of ipsilateral ACL revision surgery after the BEAR procedure. Younger patients with higher tibial slopes should be aware of the increased risk for revision surgery when deciding to undergo ACL restoration.