bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factores condicionantes de la transferencia de la formación permanente del profesorado no universitario.
Authors: Pamies Berenguer Marcial , Gomariz Vicente María Ángeles , Cascales Martínez Antonia 
Published: February 2022

Teachers' professional development plans constitute the main mechanism of action to improve the services offered by educational organizations and the performance of the functions of teachers. The study of the transfer of learning developed in permanent training activities to the job constitutes a problem of great interest as it is a necessary element to be able to analyze the performance of training activities. This research explores the factorial structure that determines the transfer of permanent training for non-university teachers, analyzes the analogies and differences with other models and proposes a measurement instrument adapted to non-university teaching. The methodology used follows a non-experimental, quantitative design based on a cross-sectional survey-type design. The sample is made up of 4,769 non-university teachers from the Region of Murcia, obtained through a non-probabilistic convenience sampling. The analysis followed a quantitative-correlational approach using statistical factor analysis techniques and the study of internal consistency. The research has made it possible to propose a factorial model and a measurement instrument, validated in content and construct, for transfer factors in non-university education.
Los planes de desarrollo profesional de los docentes constituyen el mecanismo principal de actuación para la mejora de los servicios ofrecidos por las organizaciones educativas y del desempeño de las funciones del profesorado. El estudio de la transferencia de los aprendizajes desarrollados en las actividades de formación permanente al puesto de trabajo configura un problema de gran interés al tratarse de un elemento necesario para poder analizar del rendimiento de las actividades formativas. La presente investigación explora la estructura factorial condicionante de la transferencia de la formación permanente del profesorado no universitario, analiza las analogías y deferencias con otros modelos y propone un instrumento de medición adaptado a la enseñanza no universitaria. La metodología utilizada obedece a un diseño no experimental de tipo cuantitativo basado en un diseño transversal tipo encuesta. La muestra está formada por 4769 docentes no universitarios de la Región de Murcia, obtenidos mediante un muestreo no probabilístico por conveniencia. El análisis siguió un enfoque cuantitativo-correlacional empleando técnicas estadísticas de análisis factorial y el estudio de la consistencia interna. La investigación ha permitido proponer un modelo factorial y un instrumento de medida, validado en contenido y constructo para los factores de transferencia en la enseñanza no universitaria.
Análisis de la producción científica en el uso de la realidad virtual en la educación a partir de la estructura conceptual, social e intelectual.
Authors: Lorenzo Lledó Gonzalo 
Published: February 2022

In recent years, the use of technology in education has led to an increase in scientific production. Among the various technologies, virtual reality is acquiring greater use in educational classrooms. However, there is still no global picture of how its use is evolving within education. As a consequence, the objective is to analyze the evolution in the use of virtual reality in education by scientific mapping from the study of the conceptual, social and intellectual structure of the field of knowledge. The sample is composed of 1163 documents obtained from the Web of Science during the period 1996-2019. The results show that there are two lines of research: one of them technology and Education while the other is Medicine and Education. While the most important collaborative networks are formed by the most productive authors. Finally, the papers by Merchantz et al., (2014) and Nicholson et al., (2006) are reference elements for VR work in education.
En los últimos años el uso de la tecnología en la educación ha dado lugar a un aumento de la producción científica. Entre las diversas tecnologías, la realidad virtual esta adquiriendo un mayor uso en las aulas educativas. Sin embargo, aún no existe una imagen global de cómo está evolucionando su uso dentro de la educación. Como consecuencia, el objetivo es analizar la evolución en el uso de la realidad virtual en la educación mediante mapeado científico a partir del estudio de la estructura conceptual, social e intelectual del campo de conocimiento. La muestra está compuesta de 1163 documentos obtenidos de la Web of Science durante el periodo 1996-2019. Los resultados muestran que existen dos líneas de investigación: una de ellas tecnología y Educación mientras que la otra es Medicina y Educación. Mientras que las redes de colaboración más importantes la forman los autores más productivos. Finalmente, los documentos de Merchantz et al., (2014) y Nicholson et al., (2006) son elementos de referencia para el trabajo de la RV en educación.
Análisis de los efectos de un proyecto innovador de co-docencia en la universidad
Authors: Pla-Campas Gil , Simó-Gil Núria , Arumí-Prat Joan 
Published: February 2022

A study of a didactic innovation project in higher education based on the team-building co-teaching model is presented. The project involves the integration of two subjects with two teachers, different objectives, training loads and even different types ofclassrooms. The purpose of this research is to show the effects of the application of this unconventional teaching model in the academic experience of students and teachers. Through a qualitative approach and by means as of questionnaires, discussion groups and in-depth interviews; the research studies the effects of teaching experience in three major categories of analysis: the logistics of the program, student learning and the role of teachers. The results show different magnitude of the effects for eachdimension of analysis and, in addition, results also show different perceptions for each dimension of analysis in accordance with each agents’ perspective. As a conclusion, the work concludes the three most significant effects for starting and maintainingco-teaching projects in higher education.
Con la voluntad de mejorar la enseñanza en la universidad se presenta el estudio de un proyecto de innovación didáctica en la educación superior que se corresponde con el modelo de codocencia de creación de equipo. El proyecto implica la integración de dos asignaturas con profesores, objetivos, cargas formativas e incluso tipos de aulas diferentes. El trabajo pretende mostrarlos los efectos de la aplicación de un modelo de docencia no convencional en la experiencia académica del alumnado y del profesorado. Mediante un enfoque cualitativo y a través de cuestionarios, grupos de debate y entrevistas en profundidad se analizan los efectos de la codocencia en tres categorías de análisis distintas: la logística del programa, el aprendizaje del alumnado y el rol del profesorado. Los resultados indican que los efectos son de magnitud diferente en cada dimensión de análisis y, además, que los efectos en estas dimensiones se perciben de manera distinta según los agentes. A modo de conclusiones, el trabajo concluye los tres efectos más significativos para iniciar y mantener proyectos de codocencia en educación superior.
In vitro Measurement of Anticoagulant Effect of Acacia Nilotica Aqueous Extract on Normal Human Plasma
Authors: Naser Saeed Shaima , Elhadi Elsadig Ahmed , A. M. Hamid Tarig 
Published: February 2022

Aims: To determine the anticoagulant effect of Acacia Nilotica aqueous extract on normal human plasma.
Study Design: This is an experimental study.
Place and Duration of the Study: Department of Haematology, Faculty of Medical Laboratory sciences, Alzaiem Alazhari, Khartoum – Sudan, during the period from July – August 2021.
Methodology: A total of 20 human blood samples were collected for this study from apparently healthy subjects following ethical considerations. Samples were collected in tri-sodium citrate and platelets poor plasma (PPP) were immediately prepared by centrifugation. Aqueous solution of Acacia nilotica was prepared with distilled water (D.W), three concentrations of the solution (50%, 75% and 100%) were prepared. Prothrombin Time (PT) and Activated partial thromboplastin time (APTT) were tested by manual method before and after adding different concentrations of Acacia Nilotica solution. Statistical tests were performed by using SPSS version 16.
Results: The results of study showed that Acacia Nilotica significantly prolonged the PT and APTT results of human plasma (P values for 50%, 75% and 100% solutions were 0.000, 0.000 and 0.000 while for APTT 0.036, 0.000 and 0.000 for PT respectively). Also the study showed no significant correlation between control and A. nilotica concentrations among coagulation profile, except a significant positive correlation between control and 75% Acacia nilotica on APPT.
Conclusion: Acacia Nilotica solutions had anticoagulant effect in human plasma, and could be nominated as a potential preventive agent for thromboembolic diseases.
The critical function of metabolic reprogramming in cancer metastasis
Authors: Xie Sun‐Zhe , Pan Jun‐Jie , Xu Jian‐Feng , Zhu Wen‐wei , Qin Lun‐Xiu 
Published: February 2022

AbstractCancer metastasis is the leading cause of cancer‐related death. It is a complex, inefficient, and multistep process related to poor prognosis and high mortality of patients. Increasing evidence has shown that metabolic programming is a recognized hallmarker of cancer, plays a critical role in cancer metastasis. Metabolism alterations of glucose, lipid, and amino acid provide cancer cells with energy and substances for biosynthesis, maintain biofunctions and significantly affect proliferation, invasion, and metastasis of cancer cells. Tumor microenvironment (TME) is a complex system formed by varieties of cellular and noncellular elements. Nontumor cells in TME also undergo metabolic reprogramming or respond to metabolites to promote migration and invasion of cancer cells. A comprehensive understanding of the regulatory mechanism in metastasis from the metabolic reprogramming aspect is required to develop new therapeutic strategies combatting cancer metastasis. This review illustrates the metabolic reprogramming and interaction of cancer cells and nontumor cells in the TME, and the development of treatment strategies targeting metabolism alterations.
Increased risk of cancer in dogs and humans: A consequence of recent extension of lifespan beyond evolutionarily determined limitations?
Authors: Sarver Aaron L. , Makielski Kelly M. , DePauw Taylor A. , Schulte Ashley J. , Modiano Jaime F. 
Published: February 2022

AbstractCancer is among the most common causes of death for dogs (and cats) and humans in the developed world, even though it is uncommon in wildlife and other domestic animals. We provide a rationale for this observation based on recent advances in our understanding of the evolutionary basis of cancer. Over the course of evolutionary time, species have acquired and fine‐tuned adaptive cancer‐protective mechanisms that are intrinsically related to their energy demands, reproductive strategies, and expected lifespan. These cancer‐protective mechanisms are general across species and/or specific to each species and their niche, and they do not seem to be limited in diversity. The evolutionarily acquired cancer‐free longevity that defines a species’ life history can explain why the relative cancer risk, rate, and incidence are largely similar across most species in the animal kingdom despite differences in body size and life expectancy. The molecular, cellular, and metabolic events that promote malignant transformation and cancerous growth can overcome these adaptive, species‐specific protective mechanisms in a small proportion of individuals, while independently, some individuals in the population might achieve exceptional longevity. In dogs and humans, recent dramatic alterations in healthcare and social structures have allowed increasing numbers of individuals in both species to far exceed their species‐adapted longevities (by two to four times) without allowing the time necessary for compensatory natural selection. In other words, the cancer‐protective mechanisms that restrain risk at comparable levels to other species for their adapted lifespan are incapable of providing cancer protection over this recent, drastic, and widespread increase in longevity.
Contact Separation Triboelectric Nanogenerator Based Neural Interfacing for Effective Sciatic Nerve Restoration
Authors: Zhou Mi , Huang Mingkun , Zhong Hao , Xing Cong , An Yang , Zhu Rusen , Jia Zeyu , Qu Haodong , Zhu Shibo , Liu Song , Wang Liyue , Ma Hongpeng , Qu Zhigang , Ning Guangzhi , Feng Shiqing 
Published: February 2022

AbstractPeripheral nerve injuries represent one of the most common causes of permanent disabilities. Therapeutic electrical stimulation has been widely used in neural regeneration for decades. Combined with the implantation of a nerve cuff, several outcomes have proven effectiveness and feasibility in neuroprosthetic applications. However, the current electrical stimulation strategy fails to complete nerve repair. There is a lack of research on long‐term implantable nanogenerators in the neurostimulation scenario. Especially considering many disease models, those devices may not reach the in vitro simulative working setting. Thus, an implanted sciatic nerve stimulation system that spontaneously generates biphasic electric pulses in response to rats’ movement is developed. The electric signals generated by this device could stimulate injured sciatic nerve by cuff electrode. This work introduces an implantable self‐regulated neural electrical stimulation system generated by a contact separation triboelectric nanogenerator with a nerve cuff electrode and compares it with chronic therapeutic electrical stimulation for sciatic nerve restoration effect. Neural function restoration is observed in gait and histological analysis. Moreover, the upregulation of growth associated protein 43 can be a protentional target. This could have potential clinical application in facilitating closed‐loop energy harvesting for long‐term electrical stimulation.
Full‐Dimensional Grain Boundary Stress Release for Flexible Perovskite Indoor Photovoltaics
Authors: Chen Chun‐Hao , Su Zhen‐Huang , Lou Yan‐Hui , Yu Yan‐Jun , Wang Kai‐Li , Liu Gen‐Lin , Shi Yi‐Ran , Chen Jing , Cao Jun‐Jie , Zhang Liang , Gao Xing‐Yu , Wang Zhao‐Kui 
Published: February 2022

AbstractPerovskite photovoltaics are strong potential candidates to drive low‐power off‐grid electronics for indoor applications. Compared with rigid devices, flexible perovskite devices can provide a more suitable surface for indoor small electronic devices, enabling them have a broader indoor application prospect. However, the mechanical stability of flexible perovskite photovoltaics is an urgent issue solved. Herein, a kind of 3D crosslinking agent named borax is selected to carry out grain boundary penetration treatment on perovskite film to realize full‐dimensional stress release. This strategy improves the mechanical and phase stabilities of perovskite films subjected to external forces or large temperature changes. The fabricated perovskite photovoltaics deliver a champion power conversion efficiency (PCE) of 21.63% under AM 1.5G illumination, which is the highest one to date. The merit of low trap states under weak light makes the devices present a superior indoor PCE of 31.85% under 1062 lux (LED, 2956 K), which is currently the best flexible perovskite indoor photovoltaic device. This work provides a full‐dimensional grain boundary stress release strategy for highly stable flexible perovskite indoor photovoltaics.
Prospects of Metal‐Free Perovskites for Piezoelectric Applications
Authors: Wu Han‐Song , Murti Bayu Tri , Singh Jitendra , Yang Po‐Kang , Tsai Meng‐Lin 
Published: February 2022

AbstractMetal‐halide perovskites have emerged as versatile materials for various electronic and optoelectronic devices such as diodes, solar cells, photodetectors, and sensors due to their interesting properties of high absorption coefficient in the visible regime, tunable bandgap, and high power conversion efficiency. Recently, metal‐free organic perovskites have also emerged as a particular class of perovskites materials for piezoelectric applications. This broadens the chemical variety of perovskite structures with good mechanical adaptability, light‐weight, and low‐cost processability. Despite these achievements, the fundamental understanding of the underlying phenomenon of piezoelectricity in metal‐free perovskites is still lacking. Therefore, this perspective emphasizes the overview of piezoelectric properties of metal‐halide, metal‐free perovskites, and their recent progress which may encourage material designs to enhance their applicability towards practical applications. Finally, challenges and outlooks of piezoelectric metal‐free perovskites are highlighted for their future developments.
Manipulating molecular aggregation and crystalline behavior of A‐DA'D‐A type acceptors by side chain engineering in organic solar cells
Authors: Liu Wei , Zhang Rui , Wei Qingya , Zhu Can , Yuan Jun , Gao Feng , Zou Yingping 
Published: February 2022

AbstractAlkyl chains engineering plays an important role in photovoltaic materials for organic solar cells. Herein, three A‐DA'D‐A (acceptor–donor–acceptor'–donor–acceptor) type acceptors named Y6, Y6‐C4, and Y6‐C5 with different branching position on the pyrrole motif are discussed and the relationship between molecular aggregation, crystalline, and device performance are systematically investigated. The distance between the branching position and the main backbone affects their optical absorption and energy levels. Y6‐C4 and Y6‐C5 with the branching position at the fourth and fifth carbon of the alkyl chain show blue‐shifted absorption and increased electrochemical bandgaps, compared with Y6 with the branching position at the second carbon of the alkyl side chain. In addition, this distance influences the molecular aggregation and crystalline behavior of the donor/acceptor blends. Compared with Y6‐C4, Y6‐C5 possesses a stronger crystalline and aggregate ability in the blends with a lower non‐radiative energy loss, which results in a higher open circuit voltage (Voc) of 0.88 V. Finally, Y6‐C5‐based binary device achieved a high power conversion efficiency up to 16.73% with afill factor (FF) of 0.78. These results demonstrate that the side chain engineering is an effective strategy for tuning the molecular aggregation and crystalline to improve photovoltaic performance of the A‐DA'D‐A type acceptors.
The role of hydrogen‐bond in solubilizing drugs by ionic liquids: A molecular dynamics and density functional theory study
Authors: Huang Yiping , Ouyang Defang , Ji Yuanhui 
Published: February 2022

AbstractThe solvation mechanisms of aspirin and etomidate in four combinations of [Emim]+ and [BuGun]+ paired with [OAc]− and [NTf2]− were systematically studied by molecular dynamics simulations and DFT calculations. It was shown that the favorable solvation of aspirin and etomidate correlated well with hydrogen‐bond (H‐bond) basicity of anions and the H‐bond acidity of cations, respectively. Wherein, the H‐bond between aspirin and [OAc]− anion with high H‐bond basicity possessed covalent feature, so ILs containing [OAc]− anion has the best effective in solubilizing aspirin. However, H‐bond interactions between etomidate and cations exhibited an electrostatic dominant, and moderate cation–anion interaction could weaken it. Accordingly, for etomidate, the best ILs solvent comprised a weakly interacting anion and a cation with strong H‐bond acidity, that is, [BuGun][NTf2]. This solvation difference was because aspirin with carboxyl group displayed strongly H‐bond donating characteristic, whereas etomidate with no active hydrogen protons mainly formed H‐bond with cations. Additionally, we found that π–π stacking interactions were of secondary importance for the solubilization of etomidate, but little for aspirin. These simulations will be helpful for experimental design new ILs to solubilize some drugs with aspirin‐like or etomidate‐like structures.
Paternal uniparental disomy of chromosome 2 resulting in a concurrent presentation of Crigler–Najjar syndrome type I and long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency
Authors: Knapp Anna , Jagła Mateusz , Madetko‐Talowska Anna , Szewczyk Katarzyna , Książek Teofila , Końska Katarzyna , Kwinta Przemko 
Published: February 2022

AbstractThis is the first report of the concurrent development of long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency (LCHADD) and Crigler–Najjar syndrome type 1 (CNs1) inherited via uniparental disomy of chromosome 2, which are both autosomal recessive pathologies. Through an expanded newborn metabolic panel, a male infant was identified as having an acylcarnitine pattern typical for LCHADD, later confirmed to be caused by a well‐characterized pathogenic variant in the HADHA gene located at 2p23. Prolonged non‐hematologic jaundice requiring repetitive phototherapy prompted further genetic analysis, leading to the identification of another genetic abnormality consistent with CNs1, which was caused by a novel pathogenic variant in the UGT1A1 gene located at 2q37. The two identified point mutations in chromosome 2 were homozygous and present on separate arms, which indicated potential uniparental disomy. Microarray analysis of the genetic material from the patient and his parents confirmed paternal isodisomy of chromosome 2. Further studies are needed to identify other possible pathogenic variants located on the same defective chromosome, evaluate the combined effect of the two metabolic abnormalities, and plan the best possible treatment and care.
Cooperative Gold/Zinc‐Catalyzed Cascade Approach to Tryptophan Derivatives from N‐arylhydroxylamines and Alkynes
Authors: Wang Min , Liu Xiao , Wang Liying , Lu Haifeng , Gao Hongyin 
Published: February 2022

AbstractA cooperative gold/zinc catalyzed strategy for the synthesis of tryptophan derivatives from easily prepared N‐arylhydroxylamines and chiral amino acid tethered alkynes with high efficiency has been developed. The structurally diverse tryptophan derivatives including pharmaceutical relevant molecules can be readily prepared by this method. This tandem transformation starts from acyclic simple materials rather than the existing methods by modifying indole skeletons.
Large Terahertz Phase Shift Induced by Photothermal Effect of Gold Nanoparticles Incorporated with Toluene
Authors: Li Yuanpeng , Zhang Dainan , Liao Yulong , Zhong Zhiyong , Wen Tianlong 
Published: February 2022

AbstractPhase and amplitude modulation of propagating terahertz (THz) waves in free space is essential for many rapidly developing THz technologies. Herein, an all‐optical, high‐performance, and ultra‐broadband THz phase shifter is demonstrated. Tunable phase shift is achieved by the photothermal effect of plasmonic gold nanoparticles in toluene, which can induce variations in the THz refractive index of toluene as the temperature increases. A phase shift of 270° at 1 THz can be achieved under a laser irradiation of 2.5 W (3.9 W cm−2) on the mixture solution. Constructive and destructive interference of THz waves can be achieved by tuning the relative phase of two split THz waves, which can be controlled by the power of the irradiation laser. This is the first broadband THz phase modulator in free space driven by optical stimuli, and it provides a new solution for tuning the phase shift of THz waves.