bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct modelling from GPS data reveals daily-activity-dependency of effective reproduction number in COVID-19 pandemic
Authors: Ozaki Jun’ichi , Shida Yohei , Takayasu Hideki , Takayasu Misako 
Published: October 2022

AbstractDuring the COVID-19 pandemic, governments faced difficulties in implementing mobility restriction measures, as no clear quantitative relationship between human mobility and infection spread in large cities is known. We developed a model that enables quantitative estimations of the infection risk for individual places and activities by using smartphone GPS data for the Tokyo metropolitan area. The effective reproduction number is directly calculated from the number of infectious social contacts defined by the square of the population density at each location. The difference in the infection rate of daily activities is considered, where the ‘stay-out’ activity, staying at someplace neither home nor workplace, is more than 28 times larger than other activities. Also, the contribution to the infection strongly depends on location. We imply that the effective reproduction number is sufficiently suppressed if the highest-risk locations or activities are restricted. We also discuss the effects of the Delta variant and vaccination.
Induction of distinct plant cell death programs by secreted proteins from the wheat pathogen Zymoseptoria tritici
Authors: Welch Thomas , Bayon Carlos , Rudd Jason J. , Kanyuka Kostya , Kettles Graeme J. 
Published: October 2022

AbstractCell death processes in eukaryotes shape normal development and responses to the environment. For plant–microbe interactions, initiation of host cell death plays an important role in determining disease outcomes. Cell death pathways are frequently initiated following detection of pathogen-derived molecules which can lead to resistance or susceptibility to disease depending on pathogen lifestyle. We previously identified several small secreted proteins (SSPs) from the wheat-infecting fungus Zymoseptoria tritici that induce rapid cell death in Nicotiana benthamiana following Agrobacterium-mediated delivery and expression (agroinfiltration). Here we investigated whether the execution of host cells was mechanistically similar in response to different Z. tritici SSPs. Using RNA sequencing, we found that transient expression of four Z. tritici SSPs led to massive transcriptional reprogramming within 48 h of agroinfiltration. We observed that distinct host gene expression profiles were induced dependent on whether cell death occurs in a cell surface immune receptor-dependent or -independent manner. These gene expression profiles involved differential transcriptional networks mediated by WRKY, NAC and MYB transcription factors. In addition, differential expression of genes belonging to different classes of receptor-like proteins and receptor-like kinases was observed. These data suggest that different Z. tritici SSPs trigger differential transcriptional reprogramming in plant cells.
Cognitive penetrability of scene representations based on horizontal image disparities
Authors: Chen Yulan D. , Kaestner Milena , Norcia Anthony M. 
Published: October 2022

AbstractThe structure of natural scenes is signaled by many visual cues. Principal amongst them are the binocular disparities created by the laterally separated viewpoints of the two eyes. Disparity cues are believed to be processed hierarchically, first in terms of local measurements of absolute disparity and second in terms of more global measurements of relative disparity that allow extraction of the depth structure of a scene. Psychophysical and oculomotor studies have suggested that relative disparities are particularly relevant to perception, whilst absolute disparities are not. Here, we compare neural responses to stimuli that isolate the absolute disparity cue with stimuli that contain additional relative disparity cues, using the high temporal resolution of EEG to determine the temporal order of absolute and relative disparity processing. By varying the observers’ task, we assess the extent to which each cue is cognitively penetrable. We find that absolute disparity is extracted before relative disparity, and that task effects arise only at or after the extraction of relative disparity. Our results indicate a hierarchy of disparity processing stages leading to the formation of a proto-object representation upon which higher cognitive processes can act.
Top-down modulation impairs priming susceptibility in complex decision-making with social implications
Authors: Bernal Franco Agustín , Salgueiro Tomás Alves , Brzostowski Axel , Zapata Emilio Recart , Carames Ayelén , Pérez Juan Manuel , Furman Damián , Graziano Martín , Larrosa Pablo Nicolás Fernández 
Published: October 2022

AbstractCould social context variables prime complex decisions? Could top-down processes impair this priming susceptibility? Complex decisions have been mainly studied from economic and moral perspectives, and Dual Process Theories provide evidence of how these processes could be affected. To address these issues from a political perspective, online experiments were conducted. Participants (n = 252) were asked to choose a face from 4 options, each associated with different frequencies (repetition priming) or with phrases with different emotional valence (emotional priming), for an unspecified task (UST group) or an important task (IMT group). The most repeated face was chosen most in the UST group, and was associated with lower response times. Positive faces were equally chosen by both groups. To compare results in a more ecological situation, a social study was conducted during the 2019 Argentine Presidential Election, including online surveys (n = 3673) and analysis of news media mentioning candidates. The familiarity and trust to each candidate explained the voting-probability for most of them, as well as correlated with their frequency of mentions in the news, their positive associations, and election results. Our results suggest complex decision-making is susceptible to priming, depending on top-down modulation.
Profile of Tabriz Older People Health Survey (TOPS-2019): a representative community-based cross-sectional study
Authors: Araj-Khodaei Mostafa , Sanaie Sarvin , Nejadghaderi Seyed Aria , Sullman Mark J. M. , Samei-Sis Sirous , Taheri-Targhi Somaiyeh , Yousefi Zahra , Matlabi Hossein , Safiri Saeid , Azizi-Zeinalhajlou Akbar 
Published: October 2022

AbstractPopulation aging and its consequences are a substantial global concern. The growth in the number of older people is one of the most important factors increasing the burden of non-communicable diseases (NCDs) on society. The Tabriz Older People Health Survey aimed to understand the socio-demographics, health-related behaviors, and health profile of older adults. This cross-sectional study was conducted on a representative sample of 1362 community-dwelling older adults in Tabriz, the most populated city in northwest Iran. The study used probability proportionate to size sampling and the data collection was undertaken in each participants’ place of residence from July 2019 to January 2020. Trained interviewers administered the questionnaire, which measured each participant’s socio-demographics, health-related behaviors, and health profile. The sample of 1362 participants consisted of 56.4% women and 54.4% were young older people (60–69 years old). Almost half of the sample were completely illiterate. There was no daily walking in 13.3% of the sample, with women reporting a more sedentary lifestyle than men. Almost 10% of the participants (n = 135, 9.9%) were current smokers, which was higher among men (20.9% vs. 1.5%) and women made up over 88% of those living alone. In terms of sleep quality score (men: 4.63 ± 2.70, women: 5.97 ± 2.93), anxiety (men: 5.79 ± 4.70, women: 7.59 ± 5.51), depression (men: 9.54 ± 3.20, women: 10.63 ± 3.09), and social support (men: 23.65 ± 4.50, women: 22.69 ± 4.77), men were significantly better than women. There were also significant sex differences between women and men in the prevalence of diabetes (31.6% vs. 19.5%) and hypertension (86.5% vs. 73.4%). Furthermore, overall hypertension was the most common underlying disease (81.0%). Older women were significantly worse off than older men, in terms of social and disability-related, as well as having a higher burden from several NCDs. The results of this study might help regional health policymakers to identify targets for improving the health status among community-housed geriatrics.
A study of safety acceptance and behavioral interventions for autonomous driving technologies
Authors: Deng Mingyang , Guo Yingshi 
Published: October 2022

AbstractExplaining the phenomenon of declining acceptance of automated driving technology (ADT) and predicting trends in acceptance has become an important area of research. To explore the reasons for the decline in acceptance of automated vehicles and how to improve user acceptance, we studied mechanisms of the influence process from the relationship between safety riskiness of ADT and user acceptance, and examined the mediating and moderating effects of the proposed intervention behaviors on the influence relationship between these two. First, an improved acceptance model incorporating safety risk factors was developed. Subsequently, the psychological change process of user acceptance was analyzed based on people’s response to accident information. Ultimately, the results show that safety cognition risk regarding ADT has a significant negative impact on user acceptance. Next, the mediating model where user experience was introduced as a moderating variable was designed. From the test results of this model, it is found that the proposed behavioral intervention strategy is effective in attenuating the degree of impact of the safety riskiness of ADT on acceptance. The risk-based acceptance explanation model and intervention method designed in this study provide a scientific basis and practical approach to develop the market for automated vehicles.
The synergy of β amyloid 1-42 and oxidative stress in the development of Alzheimer’s disease-like neurodegeneration of hippocampal cells
Authors: Karapetyan Gohar , Fereshetyan Katarine , Harutyunyan Hayk , Yenkoyan Konstantin 
Published: October 2022

AbstractAlzheimer’s disease (AD) is a type of dementia that affects memory, thinking and behavior. Symptoms eventually become severe enough to interfere with daily tasks. Understanding the etiology and pathogenesis of AD is necessary for the development of strategies for AD prevention and/or treatment, and modeling of this pathology is an important step in achieving this goal. β-amyloid peptide (Aβ) injection is a widely used approach for modeling AD. Nevertheless, it has been reported that the model constructed by injection of Aβ in combination with a prooxidant cocktail (ferrous sulfate, Aβ, and buthionine sulfoximine (BSO) (FAB)) best reflects the natural development of this disease. The relationship between oxidative stress and Aβ deposition and their respective roles in Aβ-induced pathology in different animal models of AD have been thoroughly investigated. In the current paper, we compared the effects of Aβ 1-42 alone with that of Aβ-associated oxidative stress induced by the FAB cocktail on the neurodegeneration of hippocampal cells in vitro. We constructed a FAB-induced AD model using rat primary hippocampal cells and analyzed the contribution of each compound. The study mainly focused on the prooxidant aspects of AD pathogenesis. Moreover, cellular bioenergetics was assessed and routine metabolic tests were performed to determine the usefulness of this model. The data clearly show that aggregated Aβ1-42 alone is significantly less toxic to hippocampal cells. Aggregated Aβ damages neurons, and glial cells proliferate to remove Aβ from the hippocampus. External prooxidant agents (Fe2+) or inhibition of internal antioxidant defense by BSO has more toxic effects on hippocampal cells than aggregated Aβ alone. Moreover, hippocampal cells fight against Aβ-induced damage more effectively than against oxidative damage. However, the combination of Aβ with external oxidative damage and inhibition of internal antioxidant defense is even more toxic, impairs cellular defense systems, and may mimic the late phase of AD-associated cell damage. Our findings strongly indicate a critical role for the combination of Aβ and oxidative stress in the development of neurodegeneration in vitro.
Prevalence of prediabetes, diabetes, diabetes awareness, treatment, and its socioeconomic inequality in west of Iran
Authors: Moradpour Farhad , Rezaei Satar , Piroozi Bakhtiar , Moradi Ghobad , Moradi Yousef , Piri Negar , Shokri Azad 
Published: October 2022

AbstractWe aim to estimate the prevalence of prediabetes, and diabetes mellitus (DM). We estimated awareness, treatment, plasma glucose control, and associated factors in diabetes, as well as, socioeconomic-related inequality in the prevalence of diabetes and prediabetes. Data for adults aged 35–70 years were obtained from the baseline phase of the Dehgolan prospective cohort study (DehPCS). Diabetes status was determined as fasting plasma glucose (FPG) of ≥ 126 mg/dl and/or taking glucose lowering medication confirmed by a medical practitioner. Prediabetes was considered as 100 ≤ FPG ≤ 125 mg/dl. The relative concentration index (RCI) was used to exhibit socioeconomic inequality in the prevalence of prediabetes and DM. Prevalence of prediabetes and DM, diabetes awareness and treatment, and glycemic control of DM 18.22%, 10.00%, 78.50%, 68.91% and, 28.50%, respectively. Increasing age (p < 0.001), Increasing body mass index (BMI) (p < 0.05), ex-smoker (p < 0.01), family history of diabetes (FHD) (p < 0.001), and comorbidity (p < 0.001) were independent risk factors for DM. Age group of 46–60 (p < 0.05), ex-smoker (p < 0.05), FHD (p < 0.05) were increased chance of awareness. Current smokers (p < 0.05), and higher education increase the chance of glycemic control in DM. Both DM (RCI =  − 0.234) and prediabetes (RCI =  − 0.122) were concentrated significantly among less-educated participants. DM was concentrated significantly among poor (RCI =  − 0.094) people. A significant proportion of DM awareness and treatment can be due to the integration of diabetes into the primary health care system. The high prevalence of prediabetes and diabetes, which is affected by socioeconomic inequality and combined with low levels of glycemic control may place a greater burden on the health system. Therefore, awareness, receiving treatment, and glycemic control in people with diabetes, and the socioeconomic status of people have become increasingly important in the near future.
The role of incoming flow on crystallization of undercooled liquids with a two-phase layer
Authors: Alexandrov Dmitri V. , Toropova Liubov V. 
Published: October 2022

AbstractMotivated by important applications of crystallization phenomena, we consider a directional solidification process for a binary melt with a two-phase (mushy) layer in the presence of weak melt flow. We consider the steady-state solidification scenario, so that the two-phase layer filled with solid and liquid material keeps its thickness. In addition, we consider that the melt flows onto the two-phase layer slowly in the opposite direction to directional crystallization and solidifies there. A complete analytical solution to non-linear two-phase layer equations is constructed in a parametric form, where the solid phase fraction represents a decision variable. The temperature and solute concentration distributions, mushy layer permeability and average interdendritic spacing as well as solidification velocity and mushy layer thickness are analytically determined. We show that incoming melt flow plays a decisive role on mushy layer parameters and internal structures. The solid phase fraction within the two-phase layer and its thickness essentially grow while the mushy layer permeability and average interdendritic spacing decrease with increasing intensity of incoming melt flow.
Attentional modulation of interhemispheric (a)symmetry in children with developmental language disorder
Authors: Hernández Doris , Kärkkäinen Salme , Tulonen Terhi , Helenius Päivi , Salmelin Riitta , Parviainen Tiina 
Published: October 2022

AbstractThe nature of auditory processing problems in children with developmental language disorder (DLD) is still poorly understood. Much research has been devoted to determining the extent to which DLD is associated with general auditory versus language-specific dysfunction. However, less emphasis has been given to the role of different task conditions in these dysfunctions. We explored whether children with DLD demonstrate atypical interhemispheric asymmetry during the auditory processing of speech and non-speech sounds and whether this interhemispheric balance is modulated by attention. Magnetoencephalography was used to record auditory evoked fields in 18 children (9 to 10 years old), 9 with DLD and 9 with language typical development, during active or passive listening to speech and non-speech sounds. A linear mixed model analysis revealed a bilateral effect of attention in both groups. Participants with DLD demonstrated atypical interhemispheric asymmetry, specifically in the later (185–600 ms) time window but only during the passive listening condition. During the active task, the DLD group did not differ from the typically developed children in terms of hemispheric balance of activation. Our results support the idea of an altered interhemispheric balance in passive auditory response properties in DLD. We further suggest that an active task condition, or top–down attention, can help to regain leftward lateralization, particularly in a later stage of activation. Our study highlights the highly dynamic and interhemispheric nature of auditory processing, which may contribute to the variability in reports of auditory language processing deficits in DLD.
High gain/bandwidth off-chip antenna loaded with metamaterial unit-cell impedance matching circuit for sub-terahertz near-field electronic systems
Authors: Alibakhshikenari Mohammad , Virdee Bal S. , Mariyanayagam Dion , Vadalà Valeria , Naser-Moghadasi Mohammad , See Chan H. , Dayoub Iyad , Aïssa Sonia , Livreri Patrizia , Burokur Shah Nawaz , Pietrenko-Dabrowska Anna , Falcone Francisco , Koziel Slawomir , Limiti Ernesto 
Published: October 2022

AbstractAn innovative off-chip antenna (OCA) is presented that exhibits high gain and efficiency performance at the terahertz (THz) band and has a wide operational bandwidth. The proposed OCA is implemented on stacked silicon layers and consists of an open circuit meandering line. It is shown that by loading the antenna with an array of subwavelength circular dielectric slots and terminating it with a metamaterial unit cell, its impedance bandwidth is enhanced by a factor of two and its gain on average by about 4 dB. Unlike conventional antennas, where the energy is dissipated in a resistive load, the technique proposed here significantly reduces losses. The antenna is excited from underneath the antenna by coupling RF energy from an open-circuited feedline through a slot in the ground-plane of the middle substrate layer. The feedline is shielded with another substrate layer which has a ground-plane on its opposite surface to mitigate the influence of the structure on which the antenna is mounted. The antenna has the dimensions 12.3 × 4.5 × 0.905 mm3and operates across the 0.137–0.158 THz band corresponding to a fractional bandwidth of 14.23%. Over this frequency range the average measured gain and efficiency are 8.6 dBi and 77%, respectively. These characteristics makes the proposed antenna suitable for integration in sub-terahertz near-field electronic systems such as radio frequency identification (RFID) devices with high spatial resolution.
Physiologic and molecular responses of indica–japonica subspecies tetraploid rice seed germination to ion beams
Authors: Huang Yaqin , Li Jinzhe , Huang Qunce 
Published: October 2022

AbstractIonizing radiation can not only reduce the yield of rice but also cause rice toxicity, and consumption of this kind of rice threatens human health. Moreover, the production and application of freon has further caused a hole in the earth’s ozone layer, increasing the amount of ionizing radiation from the sun affecting rice. To select and breed new radiation-resistant rice varieties, dry seeds of theindica–japonicasubspecies of tetraploid rice subjected to different doses of ionizing radiation were investigated for their responses during germination. The results showed that the relative water absorption, seed vigour and GA3content sharply decreased in response to three different doses of ionizing radiation, and the regulation of the expression of genes related to α-amylase synthesis and gibberellin metabolism was disrupted. Moreover, the degree of inhibition increased with increasing dose. Notably, under 3.0 × 1017ions/cm2radiation, an upregulation ofOsGA3ox2expression resulted in a sharp increase in GA3content in theindica–japonicatetraploid rice, and upregulated expression ofOsAmy3AandOsAmy3Dresulted in sharp increase in α-amylase activity, water absorption, and sucrose and fructose contents, which resulted in the seed vigour being greater than that of its parents. The results indicate that additional research on the physiological and molecular features ofindica–japonicatetraploid rice seed germination in response to ionizing radiation is needed.
The potential key genes and pathways associated with Wilms tumor in quest of proper candidates for diagnostic and therapeutic purposes
Authors: Bitaraf Masoud , Mahmanzar Mohammadamin , Zafari Narges , Mohammadpour Hadiseh , Vasei Mohammad , Moradi Matin Leyla , Kajbafzadeh Abdol-Mohammad , Majidi Zolbin Masoumeh 
Published: October 2022

AbstractTo designate the probable most important differentially expressed genes and genetic pathways in Wilms tumor and assess their expression and diagnostic potential by RT-PCR and statistical analysis. Systematic review of the literature and various bioinformatics analysis was carried out to gather and narrow down data. The expression of end-resulting genes was compared in Wilms tumor and normal tissue samples using RT-PCR. Statistical tests reported the diagnostic accuracy of genes and their correlation with clinicopathological features. Four genes including CDH1, NCAM1, EGF, and IGF2 were designated. The panel combining them has 100% sensitivity and specificity in differentiating tumors from normal tissue. Eight pathways, most involved in cell–cell and cell-basal matrix junction interactions, were found to be associated with disease pathogenesis. The suggested genes should undergo further evaluation to be validated as diagnostic biomarkers. Further research on the eight proposed pathways is recommended.
Modeling electronic health record data using an end-to-end knowledge-graph-informed topic model
Authors: Zou Yuesong , Pesaranghader Ahmad , Song Ziyang , Verma Aman , Buckeridge David L. , Li Yue 
Published: October 2022

AbstractThe rapid growth of electronic health record (EHR) datasets opens up promising opportunities to understand human diseases in a systematic way. However, effective extraction of clinical knowledge from EHR data has been hindered by the sparse and noisy information. We present Graph ATtention-Embedded Topic Model (GAT-ETM), an end-to-end taxonomy-knowledge-graph-based multimodal embedded topic model. GAT-ETM distills latent disease topics from EHR data by learning the embedding from a constructed medical knowledge graph. We applied GAT-ETM to a large-scale EHR dataset consisting of over 1 million patients. We evaluated its performance based on topic quality, drug imputation, and disease diagnosis prediction. GAT-ETM demonstrated superior performance over the alternative methods on all tasks. Moreover, GAT-ETM learned clinically meaningful graph-informed embedding of the EHR codes and discovered interpretable and accurate patient representations for patient stratification and drug recommendations. GAT-ETM code is available at https://github.com/li-lab-mcgill/GAT-ETM.