bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of physical exercise and body weight on disease-specific outcomes of people with rheumatic and musculoskeletal diseases (RMDs): systematic reviews and meta-analyses informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs
Authors: Gwinnutt James M , Wieczorek Maud , Cavalli Giulio , Balanescu Andra , Bischoff-Ferrari Heike A , Boonen Annelies , de Souza Savia , de Thurah Annette , Dorner Thomas E , Moe Rikke Helene , Putrik Polina , Rodríguez-Carrio Javier , Silva-Fernández Lucía , Stamm Tanja , Walker-Bone Karen , Welling Joep , Zlatković-Švenda Mirjana I , Guillemin Francis , Verstappen Suzanne M M 
Published: March 2022

BackgroundA European League Against Rheumatism (EULAR) taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). This paper reviews the literature on the effects of physical exercise and body weight on disease-specific outcomes of people with RMDs.MethodsThree systematic reviews were conducted to summarise evidence related to exercise and weight in seven RMDs: osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, axial spondyloarthritis (axSpA), psoriatic arthritis, systemic sclerosis and gout. Systematic reviews and original studies were included if they assessed exercise or weight in one of the above RMDs, and reported results regarding disease-specific outcomes (eg, pain, function, joint damage). Systematic reviews were only included if published between 2013–2018. Search strategies were implemented in the Medline, Embase, Cochrane Library of systematic reviews and CENTRAL databases.Results236 articles on exercise and 181 articles on weight were included. Exercise interventions resulted in improvements in outcomes such as pain and function across all the RMDs, although the size of the effect varied by RMD and intervention. Disease activity was not influenced by exercise, other than in axSpA. Increased body weight was associated with worse outcomes for the majority of RMDs and outcomes assessed. In general, study quality was moderate for the literature on exercise and body weight in RMDs, although there was large heterogeneity between studies.ConclusionThe current literature supports recommending exercise and the maintenance of a healthy body weight for people with RMDs.
An investigation of bat mortality in British Columbia, Canada
Authors: Beattie Imara , Schofer Delaney , McGregor Glenna , Lee Michael J. , Lee Lisa K.F. , Himsworth Chelsea G. , Byers Kaylee A. 
Published: March 2022

Identifying causes of wildlife mortality can yield an understanding of the factors that impact wildlife health. This is particularly significant for species that are facing population declines because this information can inform conservation and management practices. We evaluated causes of mortality for bats in British Columbia, Canada, submitted to the provincial veterinary laboratory between 2015 and 2020, and assessed whether cause of death varied by species and (or) was associated with bat characteristics (e.g., sex and body condition). Of the 275 bats included in this study, the most frequent cause of death was cat depredation (24%), followed by blunt force trauma (23%). Bats that died by cat depredation tended to be in good body condition compared with those that died from other causes, and male bats were more likely to die from blunt force trauma compared with females. Emaciation was also an important cause of mortality (21%) and 8% of bats died due to rabies, with the greatest rabies prevalence in big brown bats ( Eptesicus fuscus (Palisot de Beauvois, 1796)). Our results demonstrate the potential burden of cat depredation on healthy bats and highlight the need for strategies to decrease cat depredation to support healthy bat populations.
Hide and seek with the third family hypercharge model’s $$Z^\prime $$ at the large hadron collider
Authors: Allanach B. C. , Banks Hannah 
Published: March 2022

AbstractThe Third Family Hypercharge Model predicts a $$Z^\prime $$

Z
′

gauge boson with flavour dependent couplings which has been used to explain anomalies in meson decay processes which involve the $$b\rightarrow s\mu ^+\mu ^-$$

b
→
s

μ
+

μ
-

transition. The model predicts that a TeV-scale $$Z^\prime $$

Z
′

should decay to particle-antiparticle pairs of muons, taus, top quarks and bottom quarks with appreciable branching ratios. We reinterpret various ATLAS and CMS search limits for $$Z^\prime $$

Z
′

production followed by such decays at the LHC over a parameter space of the model that results from a successful combined fit to the $$b\rightarrow s l^+ l^-$$

b
→
s

l
+

l
-

data and precision electroweak observables. Current exclusions in parameter space and expected sensitivities of the various different channels in the high-luminosity run are compared. We find that the high-luminosity run of the LHC will significantly increase the sensitivity to the model beyond the existing empirical limits, which we find to be surprisingly weak.
Mining Order-preserving Submatrices under Data Uncertainty: A Possible-world Approach and Efficient Approximation Methods
Authors: Cheng Ji , Yan Da , Qu Wenwen , Hao Xiaotian , Long Cheng , Ng Wilfred , Wang Xiaoling 
Published: March 2022

Given a data matrix\( D \), a submatrix\( S \)of\( D \)is an order-preserving submatrix (OPSM) if there is a permutation of the columns of\( S \), under which the entry values of each row in\( S \)are strictly increasing. OPSM mining is widely used in real-life applications such as identifying coexpressed genes and finding customers with similar preference. However, noise is ubiquitous in real data matrices due to variable experimental conditions and measurement errors, which makes conventional OPSM mining algorithms inapplicable. No previous work on OPSM has ever considered uncertain value intervals using the well-established possible world semantics.We establish two different definitions of significant OPSMs based on thepossible world semantics: (1) expected support-based and (2) probabilistic frequentness-based. An optimized dynamic programming approach is proposed to compute the probability that a row supports a particular column permutation, with a closed-form formula derived to efficiently handle the special case of uniform value distribution and an accurate cubic spline approximation approach that works well with any uncertain value distributions. To efficiently check the probabilistic frequentness, several effective pruning rules are designed to efficiently prune insignificant OPSMs; two approximation techniques based on the Poisson and Gaussian distributions, respectively, are proposed for further speedup. These techniques are integrated into our two OPSM mining algorithms, based on prefix-projection and Apriori, respectively. We further parallelize our prefix-projection-based mining algorithm using PrefixFPM, a recently proposed framework for parallel frequent pattern mining, and we achieve a good speedup with the number of CPU cores. Extensive experiments on real microarray data demonstrate that the OPSMs found by our algorithms have a much higher quality than those found by existing approaches.
Role of Qualitative and Quantitative Indocyanine Green Angiography to Assess Mastectomy Skin Flaps Perfusion in Nipple/Skin-Sparing and Skin-Reducing Mastectomies with Implant-Based Breast Reconstruction
Authors: Mastronardi Manuela , Fracon Stefano , Scomersi Serena , Fezzi Margherita , Bortul Marina 
Published: March 2022

Background and Objectives. Mastectomy skin flaps (MSF) necrosis is one of the most relevant complications following mastectomies with immediate breast reconstruction. The study evaluates a possible correlation between MSF qualitative and quantitative perfusion grade, using ICG angiography, and skin necrosis. Methods. Consecutive women scheduled for nipple/skin-sparing/skin-reducing mastectomy between May 2020 and April 2021 were prospectively enrolled. Patients were divided into Group 1 in the absence of superficial and full-thickness necrosis (SN; FTN) and Group 2 in the presence of both. T1 (time between ICG injection and the initial perfusion of the least perfused MSF area), ICG-Q1, and ICG-Q% (absolute and relative perfusion values of the least vascularized area) were collected. Results. 38 breasts were considered. FTN was reported in 4 breasts (10.5%) and SN in 3 (7.9%). The two groups statistically differ in T1 (Group2 > Group1) and ICG-Q% (Group1 > Group2) (

p

< 0.05). T1 could statistically predict ICG-Q1 and ICG-Q%. Both quantitative values have a sensitivity of 57% and a NPV of 89%; ICG-Q% shows higher specificity (81% vs 77%) and PPV (40% vs 36%). Conclusions. Quantitative ICG angiography may additionally reduce MSF necrosis. Moreover, longer T1 may indicate possible postoperative necrosis. Considering these factors, intraoperative changes of reconstructive strategy could be adopted to reduce reconstructive failure.
Antimicrobial Resistance Profile and Associated Factors of Group B Streptococci Colonization among Pregnant Women Attending Antenatal Clinics in Jigjiga, Southeast Ethiopia
Authors: Tesfaye Addisu , Melese Addisu , Derbie Awoke 
Published: March 2022

Background. Streptococcus agalactiae (group B Streptococcus, GBS) is one of the causes of maternal and neonatal morbidity and mortality in many parts of the world. It is associated with severe maternal and neonatal outcomes. The colonization rate, associated factors, and antimicrobial sensitivity (AST) profile of GBS among pregnant women in Eastern Ethiopia is less studied. Methods. A cross-sectional study was conducted from

1

st

March to

30

th

May, 2021 in Jigjiga. A total of 182 pregnant women with a gestational period of ≥36 weeks were included. A structured questionnaire was used to collect data on the participants’ demographic and clinical history. Vaginal-rectal samples were collected by brushing the lower vagina and rectum with a sterile cotton swab for bacteriological culture. An antimicrobial sensitivity test (AST) was performed using the Kary-Bauer disk diffusion method. Data were entered and analyzed using SPSS version 25. The logistic regression model was used to find out factors associated with GBS colonization. Results. GBS colonization among pregnant women attending antenatal care was at 15.9% (29/182). The AST result showed that the majority of the isolates were sensitive to vancomycin (96.6%), chloramphenicol (96.6%), ampicillin (93.1%) azithromycin (89.7%), and penicillin (86.2%). In contrast, the isolates were found to be resistant to ceftriaxone, erythromycin, ciprofloxacin, clindamycin, and tetracycline at 17.2%, 20.7%, 27.6%, 27.6%, and 34.5%, respectively. Multidrug resistance (MDR) was noted in 4 isolates (13.79%). GBS colonization was significantly associated a with history of preterm labor (<37 weeks of gestation) (AOR = 3.87, 95% CI = 1.36–10.9) and a history of prolonged ruptured membrane (>18 hr.) (AOR = 3.44, 95% CI = 1.34–8.83). Conclusions. The colonization rate of GBS was considerably high among pregnant women attending antenatal care in the present study area. The observed antimicrobial resistance for the common drugs and the reported MDR level calls for routine screening of pregnant women for GBS and actions to minimize antimicrobial resistance (AMR) should be strengthened.
Computation by Convective Logic Gates and Thermal Communication
Authors: Bartlett Stuart , Gao Andrew K. , Yung Yuk L. 
Published: March 2022

AbstractWe demonstrate a novel computational architecture based on fluid convection logic gates and heat flux-mediated information flows. Our previous work demonstrated that Boolean logic operations can be performed by thermally driven convection flows. In this work, we use numerical simulations to demonstrate a different , but universal Boolean logic operation (NOR), performed by simpler convective gates. The gates in the present work do not rely on obstacle flows or periodic boundary conditions, a significant improvement in terms of experimental realizability. Conductive heat transfer links can be used to connect the convective gates, and we demonstrate this with the example of binary half addition. These simulated circuits could be constructed in an experimental setting with modern, 2-dimensional fluidics equipment, such as a thin layer of fluid between acrylic plates. The presented approach thus introduces a new realm of unconventional, thermal fluid-based computation.
Mesoscale Eddy Kinetic Energy Budgets and Transfers between Vertical Modes in the Agulhas Current
Authors: Tedesco P. , Gula J. , Penven P. , Ménesguen C. 
Published: March 2022

Abstract
Western boundary currents are hotspots of mesoscale variability and eddy–topography interactions, which channel energy toward smaller scales and eventually down to dissipation. Here, we assess the main mesoscale eddies energy sinks in the Agulhas Current region from a regional numerical simulation. We derive an eddy kinetic energy (
) budget in the framework of the vertical modes. It accounts for energy transfers between energy reservoirs and vertical modes, including transfers channeled by topography. The variability is dominated by mesoscale eddies (barotropic and first baroclinic modes) in the path of intense mean currents. Eddy–topography interactions result in a major mesoscale eddy energy sink, along three different energy routes, with comparable importance: transfers toward bottom-intensified time-mean currents, generation of higher baroclinic modes, and bottom friction. The generation of higher baroclinic modes takes different forms in the Northern Agulhas Current, where it corresponds to nonlinear transfers to smaller vertical eddies on the slope, and in the Southern Agulhas Current, where it is dominated by a (linear) generation of internal gravity waves over topography. Away from the shelf, mesoscale eddies gain energy by an inverse vertical turbulent cascade. However, the Agulhas Current region remains a net source of mesoscale eddy energy due to the strong generation of eddies, modulated by the topography, especially in the Southern Agulhas Current. It shows that the local generation of mesoscale eddies dominates the net
budget, contrary to the paradigm of mesoscale eddies decay upon western boundaries.
On the ROC Area of Ensemble Forecasts for Rare Events
Authors: Ben Bouallègue Zied , Richardson David S. 
Published: March 2022

Abstract
The relative operating characteristic (ROC) curve is a popular diagnostic tool in forecast verification, with the area under the ROC curve (AUC) used as a verification metric measuring the discrimination ability of a forecast. Along with calibration, discrimination is deemed as a fundamental probabilistic forecast attribute. In particular, in ensemble forecast verification, AUC provides a basis for the comparison of potential predictive skill of competing forecasts. While this approach is straightforward when dealing with forecasts of common events (e.g., probability of precipitation), the AUC interpretation can turn out to be oversimplistic or misleading when focusing on rare events (e.g., precipitation exceeding some warning criterion). How should we interpret AUC of ensemble forecasts when focusing on rare events? How can changes in the way probability forecasts are derived from the ensemble forecast affect AUC results? How can we detect a genuine improvement in terms of predictive skill? Based on verification experiments, a critical eye is cast on the AUC interpretation to answer these questions. As well as the traditional trapezoidal approximation and the well-known binormal fitting model, we discuss a new approach that embraces the concept of imprecise probabilities and relies on the subdivision of the lowest ensemble probability category.
Unhelmeted Injured Cyclists in a Canadian Emergency Department: Cycling Behavior and Attitudes Towards Helmet Use
Authors: Varriano Brenda , Porplycia Danielle , Friedman Steven Marc 
Published: March 2022

Introduction We seek to characterize unhelmeted injured cyclists presenting to the emergency department: demographics, cycling behavior, and attitudes towards cycling safety and helmet use. Methods This was a prospective case series in a downtown teaching hospital. Injured cyclists presenting to the emergency department were recruited for a standardized survey if not wearing a helmet at time of injury and over age 18. Exclusion criteria included inability to consent (language barrier, cognitive impairment) or admission to hospital. Results We surveyed 72 UICs (unhelmeted injured cyclists) with mean age of 34.3 years (range 18–68, median 30, IQR 15.8 years). Most UICs cycled daily or most days per week in non-winter months (88.9%, n = 64). Most regarded cycling in Toronto as somewhat dangerous (44.4%, n = 32) or very dangerous (5.9%, n = 4). Almost all (98.6%, n = 71) had planned to cycle when departing home that day. UICs reported rarely (11.1%, n = 8) or never (65.3%, n = 47) wearing a helmet. Reported factors discouraging helmet use included inconvenience (31.9%, n = 23) and lack of ownership (33.3%, n = 24), but few characterized helmets as unnecessary (11.1%, n = 7) or ineffective (1.4%, n = 1). Conclusions Unhelmeted injured cyclists were frequent commuter cyclists who generally do not regard cycling as safe yet choose not to wear helmets for reasons largely related to convenience and comfort. Initiatives to increase helmet use should address these perceived barriers, and further explore cyclist perception regarding risk of injury and death.
Ethnic differences in success at application for consultant posts among United Kingdom physicians from 2011 to 2019: a retrospective cross-sectional observational study
Authors: Harvey PR , Phillips C , Newbery N , Nagamoottoo D , Woolf K , Trudgill NJ 
Published: March 2022

Summary Objectives To identify associations between success following application for consultant physician posts and demographic factors. Design Logistic regression analysis of nationwide survey data. Setting United Kingdom (UK) physicians with a recent certificate of completion of training (CCT). Participants All UK trainee physicians who received a CCT between 2010 and 2019 were surveyed. Respondents were excluded if they had not applied for a consultant post or if application data were incomplete. Main outcome measures The primary outcome measure was success over the entire consultant application process, i.e. shortlisted and offered the post following the first application. Secondary outcomes were: shortlisted following first application and offered a consultant post at first interview. Results From 7037 CCT holders surveyed, 50.7% responded. While 1198 (59.7%) respondents were white, 760 (37.9%) were from minority ethnic groups and 50 (3.5%) were of unknown ethnicity. Primary medical qualification (PMQ) country was the UK in 75.3% (n = 1512). On multivariable logistic regression analysis the independent negative associations with success were: minority ethnicity (odds ratio [OR] 0.55, 95% confidence interval [CI] 0.43–0.71); p < 0.001) vs. white; PMQ from Europe (OR 0.47, 95% CI 0.28–0.79; p = 0.004) or Asia (OR 0.68, 95% CI 0.49–0.96; p = 0.027) vs. UK PMQ; year of CCT 2012 (OR 0.40, 95% CI 0.24–0.68; p = 0.001), 2013 (OR 0.39, 95% CI 0.23–0.65; p < 0.001), and 2014 (OR 0.26, 95% CI 0.15–0.43; p < 0.001) vs. 2019. Specialties associated with lower success rates included Cardiology, Endocrinology, Genitourinary medicine, Palliative care, Renal and Respiratory, compared to Acute medicine. Conclusions Minority ethnic group candidates for consultant physician posts had lower success rates compared to white candidates after correction for important variables including specialty, time from and country of PMQ. This finding requires further evaluation to identify the causes for this variation.
A case of bisphosphonate-related osteonecrosis of the maxilla with orbital cellulitis
Authors: Tajima Shori , Matsuno Hideo , Matsumoto Fumihiko , Ikeda Katsuhisa 
Published: March 2022

Bisphosphonates are used for the treatment of bone metastases of cancer and prevention of osteoporosis. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) has unclear mechanisms, but its elucidation, prevention, and treatment are essential to improve patient outcomes. An 88-year-old woman who was taking oral bisphosphonates for 4 years presented with a 5-day history of gradual orbital pain. Computed tomography (CT) revealed bilateral maxillary sinusitis and bony destruction at the base of the right maxillary sinus and inferior orbital wall. We diagnosed her with bisphosphonate-related osteonecrosis of the maxilla. In addition to intravenous antibiotic treatment, an endoscopic sinus surgery was performed. The patient’s postoperative course was uneventful. To the best of our knowledge, this is the first case report of BRONJ with orbital cellulitis. This condition should be considered among patients taking bisphosphonates, who manifest with symptoms of orbital cellulitis and bone destruction on imaging.
Risk factors for hemolysis with centrifugal pumps in pediatric extracorporeal membrane oxygenation: Is pump replacement an answer?
Authors: Chu Jian H , Sarathy Srivats , Ramesh Sonali , Rudolph Kristina , Raghavan Madhavan L , Badheka Aditya 
Published: March 2022

Introduction Hemolysis during pediatric extracorporeal membrane oxygenation (ECMO) is associated with increased risk for renal failure and mortality. Objectives We aim to describe risk factors for hemolysis in pediatric ECMO supported by centrifugal pumps. Methods We conducted an analysis of retrospective data collected at an academic children’s hospital from January 2017 to December 2019. Measurements and results Plasma-free hemoglobin (PFH) levels were measured daily, and hemolysis was defined as PFH>50 mg/dL. Of 46 ECMO runs over 528 ECMO days, hemolysis occurred in 23 (58%) patients over a total of 40 (8%) ECMO days. In multivariable logistic regression models, VA-ECMO (aOR=4.69, 95% CI: 1.01–21.83) and higher hemoglobin (aOR = 1.38, 95% CI: 1.06–1.81) were independently associated with hemolysis. There were also non-significant trends toward increased risk for hemolysis with higher rotational pump speed (aOR=2.39, 95% CI: 0.75–7.65), higher packed red blood cell transfusions (aOR=1.15, 95% CI: 0.99–1.34), and higher cryoprecipitate transfusions (aOR=2.01, 95% CI: 0.83–4.86). Isolated pump exchanges that were performed in 12 patients with hemolysis led to significant decreases in PFH levels within 24 h (89 vs 11 mg/dL, p<0.01). Conclusions Hemolysis is common in pediatric ECMO using centrifugal pumps. Avoidance of high pump speeds and conservative administration of blood products may help to mitigate the risk for hemolysis. Furthermore, pump exchange may be an effective first-line treatment for hemolysis.