bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telemedicine dan Telenursing untuk Manajemen Pasien Rawat Jalan Selama Pandemi COVID-19: A Literatur Review
Authors: Retnaningsih Dwi , Suara Eviwindha 
Published: August 2022

Background: The coronavirus disease-19 (COVID-19) outbreak is a public health emergency of international concern. Telemedicine and telenursing are effective options to combat the COVID-19 outbreak by minimizing contact between patients and reducing staff exposure. This literature review aims to identify the role of telemedicine and telenursing services in preventing, diagnosing, treating, and controlling disease during the COVID-19 outbreak.
Methods: This article is a literature review. The data search was carried out by conducting a comprehensive literature review based on major international and national databases (Pubmed, google scholar). The data search was carried out by reviewing journals from 2012 to 2021. The literature review reviewed by researchers did not focus on randomized controlled trials (RCTs) and controlled studies only, but all research related to the covid 19 pandemic and telemedicine and telenursing.
Results: 11 studies met inclusion from 66 search results. Telemedicine and telenursing are certainly appropriate in minimizing the risk of transmitting COVID-19. This solution has the potential to prevent all forms of direct physical contact, provide continuous care to the community, and ultimately reduce morbidity and mortality in the COVID-19 outbreak.
Conclusion: The use of telemeicine and telenursing improves the provision of health services. Therefore, telemedicine and telenursing must become important tools in care services while keeping patients and health care providers safe during the COVID-19 outbreak.
Identifikasi Faktor Kejadian Penyakit Jantung Koroner Terhadap Wanita Usia ≤ 50 Tahun di RSU Haji Surabaya
Authors: Sumara Retno , Ari Nugroho , Indarti Indarti 
Published: August 2022

Coronary Heart Disease (CHD) has become the main cause of death in the world and in Indonesia. Many people have heart attacks without any symptoms. Men have a higher risk of developing coronary heart disease sooner than women. Women have a risk of coronary heart disease during menopause. Typical symptoms felt by patients with coronary heart disease are chest pain that radiates to the back, arms, neck.
This study aims to identify the risk factors for coronary heart disease in women aged 50 years at RSU Haji Surabaya. The design of descriptive analysis was carried out on all patients with CHD as many as 30 patients with Consecutive Sampling with medical record data instruments (history of hypertension, obesity, cholesterol, smoking and diabetes mellitus). The results showed that CHD in women 50 years was dominantly caused by a history of hypertension 63%, history of high cholesterol and obesity 56.7%, history of DM 43.3%, family history 10%, history of smoking 6.7%. One of the main factors causing CHD is hypertension. Increased pressure of blood vessels against arterial walls can result in endothelial damage that triggers atherosclerosis.
Hubungan Sikap Dan Durasi Kerja Dengan Keluhan Muskuloskeletal Pada Karyawan Kantor Di Rumah Sakit Prima Medika Bali
Authors: Wahyudi Antonius Tri , Pramita Indah , Daryono Daryono 
Published: August 2022

Karyawan kantor di RS Prima Medika melakukan aktivitas pekerjaan dengan sikap kerja duduk statis. Sikap ini dipertahankan selama bekerja kurang lebih dari 4 jam sampai dengan 8 jam lebih. Sikap kerja duduk dalam waktu yang lama dengan leher dan punggung tidak dalam posisi ergonomis mengakibatkan pemendekan pada otot-otot skeletal, hal ini dikarenakan terjadinya reaksi ketegangan atau kontraksi dalam jangka waktu yang panjang sehingga apabila terjadi secaara terus menerus dapat menyebabkan keluhan pada otot-otot yang mendapat beban. Metode penelitian ini adalah metode Cross Sectional dengan menggunakan responden sebanyak 27 orang karyawan kantor RS Prima Medika yang didapat berdasarkan kriteria penelitian. Alat ukur pada penelitian ini adalah Rapid Entire Body Assessment untuk mengukur sikap kerja dan lembar kuesioner Nordic Body Map untuk mengukur keluhan muskuloskeletal dari responden. Hasil pengukuran selanjutnya dilakukan uji hipotesis dengan menggunakan Spearman’s Rho Test. Hasil Spearman’s Rho Test menunjukkan nilai signifikasi 0,990 dan nilai korelasi 0,003 antara sikap kerja dengan keluhan muskuloskeletal dan nilai korelasi 0,068 dan nilai signifikasi 0,737 antara durasi kerja dengan keluhan muskuloskeletal. Hasil ini menunjukkan bahwa korelasi sikap kerja dan durasi kerja dengan keluhan muskuloskeletal memiliki hubungan searah yang sangat lemah dan tidak signifikan
Comparative Screening of Hybrids and Synthetic Maize (Zea mays L.) Cultivars for Drought-Sensitive and Drought-Tolerant Under Different Irrigation Regimes
Authors: Shah Muhammad Nadeem , Hussain Shabir , Ali Hakoomat , Khan Mehrab , Bukhari Anum , Ali Shahkar , Naveed Muhammad , Sohail Muhammad 
Published: August 2022

Water scarcity is the most serious issue in crop production around the globe. Because of less water availability, various breeding and agronomic management techniques are being used to cope with this issue. For this purpose, a pot experiment was performed to screen hybrids and synthetic maize cultivars for drought-tolerance under various irrigation regimes at green-house of Agronomic Research Farm, Bahauddin Zakariya University, Multan, Pakistan during 2017. Experimental treatments comprise five maize hybrids viz. H1=DK-6317, H2=DK-6724, H3=P-1543, H4=P-1429, and H5= P-1574 and three locally synthetic maize cultivars viz. S1= Neelum, S2= Pak- Afghoi, and S3= Sadaf and three irrigation regimes viz. Control (CK) =80%WHC (water holding capacity), low drought (LD) =60% WHC and severe drought (SD) =40% WHC. It was resulted that irrigation regimes significantly affect growth and plant water relation. Results regarding maize hybrids growth showed that maximum plant height (5.20, 46.8 and 38.77 cm), number of leaves (6.41, 6.19, and 5.65), leaf area per plant (415.5, 361.5 and 305.8 cm2), dry weight of shoot per plant (6.09, 5.09 and 4.39 g) and dry weight of root per plant (0.85, 0.82 and 0.78 g) was obtained from DK-6724 under CK, LD and SD, respectively. While the minimum plant height (45.23, 36.47 and 28.87 cm), number of leaves (5.38, 5.05 and 4.79), leaf area per plant (11.87, 10.99 and 10.01 cm2), dry weight of shoot per plant (5.71, 4.75 and 4.02 g) and dry weight of root per plant (0.66, 0.63 and 0.61 g) was measured in P-1429 under CK, LD and SD, respectively. Likewise, in synthetic cultivars, Neelum performed well followed by Pak-Afghoi and Sadaf in all irrigation regimes. Results regarding plant water relation revealed that DK-6724 and Neelum maintained their osmotic potential and are considered as drought-tolerant. While P-1429 and Sadaf could not maintain their osmotic potential and were considered as drought-sensitive under normal and drought stress.
Long-term outcome of microwave ablation for benign thyroid nodules: Over 48-month follow-up study
Authors: Du Jia-Rui , Li Wen-Hui , Quan Cheng-Hai , Wang Hui , Teng Deng-Ke 
Published: August 2022

ObjectivesThe short-term effects of microwave ablation (MWA) for the treatment of benign thyroid nodules (BTNs) were satisfactory in previous studies. However, as a slowly progressing disease, the long-term efficacy of MWA for BTNs at present is not clear. Our study aim was to assess the long-term results of MWA for BTNs after a 48-month follow-up.MethodsFrom June 2015 to September 2017, 148 patients had 148 BTNs. All patients were from the China-Japan Union Hospital of Jilin University. Careful ultrasound examinations were performed 1 day, 1 month, 3 months, 6 months, 12 months, and every 6 months after MWA. The volume, volume reduction rate (VRR), recurrence rate of the ablated area and thyroid function were recorded.ResultsThe mean volumes of the 148 nodules were 15.6 ± 9.4 cm3 (range: 1.3-48.9 cm3) and 0.6 ± 0.6 cm3 (range: 0-3.5 cm3) before and 48 months after MWA, respectively, with a nodule VRR of 96.9 ± 2.5% (range: 90.4-100%). Two patients (1.35%) had recurrence after MWA. Compared with thyroid function before MWA, no significant variation was observed after MWA. Five patients experienced complications (3.38%): two patients (1.35%) had bleeding, two patients (1.35%) had ear pain and toothache during MWA, and one patient (0.68%) had hoarseness after MWA. No cases of oesophageal injury, tracheal injury, infection, skin burns, etc., were reported during or after MWA.ConclusionsBased on a long-term follow-up, MWA is an effective method for treating BTNs and is expected to be a potential first-line treatment.
Herpesvirus entry mediator on T cells as a protective factor for myasthenia gravis: A Mendelian randomization study
Authors: Zhong Huahua , Jiao Kexin , Huan Xiao , Zhao Rui , Su Manqiqige , Goh Li-Ying , Zheng Xueying , Zhou Zhirui , Luo Sushan , Zhao Chongbo 
Published: August 2022

Background and objectivesMyasthenia gravis (MG) is a T cell-driven, autoantibody-mediated disorder affecting transmission in neuromuscular junctions. The associations between the peripheral T cells and MG have been extensively studied. However, they are mainly of observational nature, thus limiting our understanding of the effect of inflammatory biomarkers on MG risk. With large data sets now available, we used Mendelian randomization (MR) analysis to investigate whether the biomarkers on T cells are causally associated with MG and further validate the relationships.MethodsWe performed a two-sample MR analysis using genetic data from one genome-wide association study (GWAS) for 210 extensive T-cell traits in 3,757 general population individuals and the largest GWAS for MG currently available (1,873 patients versus 36,370 age/gender-matched controls) from US and Italy. Then the biomarkers of interest were validated separately in two GWASs for MG in FIN biobank (232 patients versus 217,056 controls) and UK biobank (152 patients versus 386,631 controls).ResultsIn the first analysis, three T-cell traits were identified to be causally protective for MG risk: 1) CD8 on terminally differentiated CD8+ T cells (OR [95% CI] = 0.71 [0.59, 0.86], P = 5.62e-04, adjusted P =2.81e-02); 2) CD4+ regulatory T proportion in T cells (OR [95% CI] = 0.44 [0.26, 0.72], P = 1.30e-03, adjusted P =2.81e-02); 3) HVEM expression on total T cells (OR [95% CI] = 0.67 [0.52, 0.86], P = 1.61e-03, adjusted P =2.81e-02) and other eight T-cell subtypes (e.g., naïve CD4+ T cells). In particular, HVEM is a novel immune checkpoint on T cells that has never been linked to MG before. The SNPs on the TNFRSF14 per se further support a more direct link between the HVEM and MG. The validation analysis replicated these results in both FIN and UK biobanks. Both datasets showed a concordant protective trend supporting the findings, albeit not significant.ConclusionThis study highlighted the role of HVEM on T cells as a novel molecular-modified factor for MG risk and validated the causality between T cells and MG. These findings may advance our understanding of MG’s immunopathology and facilitate the future development of predictive disease-relevant biomarkers.
Lycopene-rich diets modulate HDL functionality and associated inflammatory markers without affecting lipoprotein size and distribution in moderately overweight, disease-free, middle-aged adults: A randomized controlled trial
Authors: McEneny Jane , Henry Sarah-Louise , Woodside Jayne , Moir Susan , Rudd Amelia , Vaughan Nick , Thies Frank 
Published: August 2022

BackgroundThe consumption of lycopene-rich foods may lower cardiovascular disease (CVD) risk. Lycopene circulates in the blood bound to lipoproteins, including high-density lipoproteins (HDLs). Preliminary data from our group showed that increased consumption of tomato-based food or lycopene supplement in middle-aged subjects led to functional changes to HDL's sub-fractions, HDL2 and HDL3. These changes were also associated with a decrease in serum amyloid A (SAA), potentially enhancing their anti-atherogenic properties.ObjectiveWe carried out a comprehensive randomized controlled intervention trial with healthy middle-aged volunteers to assess whether the consumption of tomato-based foods or lycopene supplements affects HDL functionality and associated inflammatory markers, and lipoprotein subfractions size and distribution.DesignVolunteers (225, aged 40–65 years) were randomly assigned to one of three dietary intervention groups and asked to consume a control diet (low in tomato-based foods, &lt;10 mg lycopene/week), a lycopene-rich diet (224–350 mg lycopene/week), or the control diet with a lycopene supplement (70 mg lycopene/week). HDL2 and HDL3 were isolated by ultracentrifugation. Compliance was monitored by assessing lycopene concentration in serum. Systemic and HDL-associated inflammation was assessed by measuring SAA concentrations. HDL functionality was determined by monitoring paraoxonase-1 (PON-1), cholesteryl ester transfer protein (CETP), and lecithin cholesterol acyltransferase (LCAT) activities. The lipoprotein subfractions profile was assessed by NMR.ResultsLycopene in serum and HDL significantly increased following consumption of both the high tomato diet and lycopene supplement (p ≤ 0.001 for both). Lycopene, either as a tomato-rich food or a supplement, enhanced both serum- and HDL3-PON-1 activities (p ≤ 0.001 and p = 0.036, respectively), while significantly reducing HDL3-SAA-related inflammation (p = 0.001). Lycopene supplement also significantly increased HDL3-LCAT activity (p = 0.05), and reduced the activity of both HDL2- and HDL3-CETP (p = 0.005 and p = 0.002, respectively). These changes were not associated with changes in the subclasses distribution for all lipoprotein fractions or the size of lipoprotein subclasses.ConclusionOur results showed that dietary lycopene can significantly enhance HDL functionality, without associated changes in particle size and distribution, by modulating the activity of HDL-associated enzymes. Concomitantly, dietary lycopene significantly decreased serum- and HDL3-associated SAA, confirming that SAA may represent a sensitive inflammatory biomarker to dietary change.Clinical Trial Register(https://www.isrctn.com), ISRCTN34203810.
Efficacy of transarterial chemoembolization monotherapy or combination conversion therapy in unresectable hepatocellular carcinoma: A systematic review and meta-analysis
Authors: Li Weiwei , Pei Yinxuan , Wang Zixiang , Liu Jinlong 
Published: August 2022

BackgroundHepatocellular carcinoma (HCC) is a highly malignant disease with poor prognosis, and most cases were already considered unresectable at the time of presentation. Conversion therapy, as an emerging treatment, is designed to provide patients with initially unresectable hepatocellular carcinoma (uHCC) the opportunity to undergo radical resection. At present, conversion therapy for patients with uHCC remains controversial. Transarterial chemoembolization (TACE) is currently the most widely selected treatment for uHCC, but its efficacy as a conversion therapy remains controversial.MethodsWe compared and evaluated the conversion rate for and tumor response to TACE monotherapy or combination therapy. Meanwhile, postoperative complications and overall survival (OS) in uHCC patients who underwent conversion therapy were also analyzed.ResultsA total of 18 studies were included in this meta-analysis. The conversion rate for triple therapy [TACE in combination with tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs)] was 42% [95% confidence interval (CI), 0.29–0.56], higher than any other group [TACE monotherapy: 10% (95% CI, 0.08–0.12), bigeminy therapy: 19% (95% CI, 0.06–0.36)]. Meanwhile, triple therapy yielded a better tumor response than TACE monotherapy or bigeminy therapy. Among the patients with successful surgical resection after conversion therapy, the pooled postoperative OS rates at 1, 2, and 5 years were 90% (95% CI, 0.81–0.97), 58% (95% CI, 0.42–0.73), and 42% (95% CI, 0.26–0.60), respectively, and the major postoperative complications were biliary leakage (7%; 95% CI, 0.03–0.12) and liver failure (3%; 95% CI, 0.00–0.07).ConclusionTACE conversion therapies showed good conversion rates, especially the triple therapy of TACE in combination with TKIs and ICIs. Surgical resection after successful conversion therapy could maximize the outcome of patients with uHCC.
Efficacy and safety of apatinib monotherapy for patients with advanced breast cancer: a systematic review and meta-analysis
Authors: Huang Xuchen , Hu Xuhua , Yi Tongbo 
Published: August 2022

BackgroundPatients with advanced breast cancer usually have poor prognosis. Apatinib is a small-molecule tyrosine kinase inhibitor, and the reports regarding the efficacy and safety of apatinib monotherapy for advanced breast cancer in the current literature are controversial. Therefore, we performed a systematic review and meta-analysis to collect and pool efficacy and safety data of apatinib monotherapy for advanced breast cancer with the aim of providing up-to-date evidence to aid clinical practice.MethodsThis study was registered at PROSPERO (CRD42020190049). Three literature databases, including PubMed, EMBASE, and Cochrane Library, were searched. For evaluating efficacy, the objective response rate and disease control rate were extracted or calculated. Safety was evaluated in terms of the proportions of patients with grade 3 or 4 treatment-related adverse events. The pooled proportions of the outcomes and their 95% confidence interval were shown. The Kaplan–Meier curves of overall survival and progression-free survival were pooled from the extracted data of the included studies. Furthermore, pooled medians for overall survival and progression-free survival were calculated. Ap-value of &lt; 0.05 was considered statistically significant.ResultsSix studies were included and deemed eligible for further quality evaluation and analysis. The pooled objective response rate and disease control rate were 20.4% and 71.6%, respectively. The pooled proportions of four hematologic adverse events ranged from 2.6% to 6.9%. The pooled proportions of hypertension, hand-foot syndrome, transaminase increased, and proteinuria ranged from 4.1% to 24.3%, and other non-hematologic adverse events were &lt;1%. The pooled median progression-free survival and overall survival were 4.00 and 10.43 months, respectively, in cases of advanced breast cancer treated with apatinib.ConclusionsThis study confirms the reliable efficacy of apatinib monotherapy for advanced breast cancer. However, non-hematologic grade 3–4 adverse events, especially hypertension, are more frequently observed during apatinib treatment than during treatment with other tyrosine kinase inhibitors, such as sunitinib or sorafenib.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42020190049.
What Plasma Can Tell Us When Tissue Cannot: A Case Report of Genomic Testing in mCRPC and Clinical Response to Treatment With the PARP Inhibitor Rucaparib
Authors: Petrylak Daniel P. , Watkins Simon P. , Loehr Andrea 
Published: August 2022

BackgroundThe poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib was approved in the United States based on the phase 2 TRITON2 study of patients with BRCA1 or BRCA2 (BRCA)–mutated metastatic castration-resistant prostate cancer (mCRPC). Although genomic screening is recommended as part of a comprehensive assessment of prostate cancer prognosis and treatment options, the best way to select patients with mCRPC for treatment with a PARP inhibitor depends on individual clinical circumstances. For example, assessment of tumor tissue may not always be feasible. Genomic testing of DNA from plasma has become more readily available, providing a minimally invasive option to evaluate DNA from primary and metastatic lesions simultaneously.Case PresentationA patient from TRITON2 with BRCA-mutated mCRPC had a response to the PARP inhibitor rucaparib and remained on treatment for 32 weeks, which was &gt;2 times longer than the duration of each of his prior therapies (bicalutamide, docetaxel, abiraterone). The patient enrolled in TRITON2 based on results of local genomic testing of an archival biopsy that indicated the presence of a BRCA1 T1399I (allelic fraction, 19%) mutation. Local testing also identified an ATM G1663C mutation, a TP53 P191del mutation, and a BRAF K601E mutation. Analysis of a plasma sample obtained before the patient started rucaparib detected the same alterations as those in the archival biopsy, but it also revealed the presence of a BRCA2 homozygous loss (whole gene, 26 of 26 exons) and several other alterations of unknown functional impact. We hypothesize the response of the patient’s tumor to rucaparib was likely driven by DNA damage repair deficiency caused by homozygous loss of all BRCA2 exons. Following discontinuation from rucaparib due to clinical disease progression, the patient received carboplatin and cabazitaxel for ≈3 weeks. The patient died due to progression of his disease.ConclusionsA notable aspect of this case is the differences in alterations detected in the archival tumor sample and a more recent plasma sample. This highlights the advantages of plasma testing compared with tissue testing when selecting targeted therapies for treatment of mCRPC; however, physicians must determine which tool presents the best solution for each individual case.
Identification for heavy metals exposure on osteoarthritis among aging people and Machine learning for prediction: A study based on NHANES 2011-2020
Authors: Xia Fang , Li Qingwen , Luo Xin , Wu Jinyi 
Published: August 2022

ObjectiveHeavy metals are present in many environmental pollutants, and have cumulative effects on the human body through water or food, which can lead to several diseases, including osteoarthritis (OA). In this research, we aimed to explore the association between heavy metals and OA.MethodsWe extracted 18 variables including age, gender, race, education level, marital status, smoking status, body mass index (BMI), physical activity, diabetes mellitus, hypertension, poverty level index (PLI), Lead (Pb), cadmium (Cd), mercury (Hg), selenium (Se), manganese (Mn), and OA status from National Health and Nutrition Examination Survey (NHANES) 2011-2020 datasets.ResultsIn the baseline data, the t test and Chi-square test were conducted. For heavy metals, quartile description and limit of detection (LOD) were adopted. To analyze the association between heavy metals and OA among elderly subjects, multivariable logistic regression was conducted and subgroup logistic by gender was also carried out. Furthermore, to make predictions based on heavy metals for OA, we compared eight machine learning algorithms, and XGBoost (AUC of 0.8, accuracy value of 0.773, and kappa value of 0.358) was the best machine learning model for prediction. For interactive use, a shiny application was made (https://alanwu.shinyapps.io/NHANES-OA/).ConclusionThe overall and gender subgroup logistic regressions all showed that Pb and Cd promoted the prevalence of OA while Mn could be a protective factor of OA prevalence among the elderly population of the United States. Furthermore, XGBoost model was trained for OA prediction.