bluuebunny/crossref_metadata_2025_split huggingface dataset:
DISCRIMINATION OF OLDER PEOPLE: MANIFESTATIONS AND COUNTERMEASURES
Authors: Koliada Nataliya , Kochubey Tetiana , Baldyniuk Olena , Batsman Olga 
Published: November 2022

The aging of the population creates problems in the relationship between representatives of different age categories, on the one hand, and on the other, it forces a critical look at the formed stereotypical ideas about old age and attitudes towards the elderly.The article analyzes the understanding of age discrimination (ageism) and age stereotypes, as well as approaches to overcoming these phenomena in modern societies.It was found out that ageism is based on the concept of norm and deviation, expectations of behavior that seems to correspond to a certain age. Various negative stereotypes in relation to the elderly are considered. Connections between stereotypes and the social position of the elderly have been established. The economic, axiological and media reasons for the formation of discriminatory attitudes towards the elderly are analyzed. In Ukraine, the following phenomena are observed: low level of social and economic activity due to insufficient educational and professional mobility of the workforce, insufficient development of institutions and traditions of self-education and continuous education throughout life in combination with a conservative employment structure and inflexibility of the labor market; the existence in the public opinion of ideas about the aging of the population as an exclusively negative process that must be fought, as well as stereotypes about senior citizens, which form a negative attitude towards them and are the basis for their discrimination in various spheres of life.Finding from the survey conducted in Poltava demonstrayed that among specialists, the smallest social distance with the elderly is observed in the family and household domains, and the largest in the professional activities.
It was determined that combating ageism and stereotypes about the оlder people can include measures at the macro level (society level), at the level of certain communities and organizations, as well as individual work with people. Ways to counteract ageism and develop the philosophy of active aging are proposed, in particular, through educational programmes and local initiatives at the community level, introduction of the intergenerational programmes and age-friendly communities.
Long-term follow-up of an overexposure radiation incident in a cohort treated with linear accelerator–based stereotactic radiosurgery for intracranial arteriovenous malformations
Authors: Borius Pierre-Yves , Januel Anne Christine , Plas Jean Yves , Duthil Pierre , Lotterie Jean Albert , Latorzeff Igor , Sabatier Jean 
Published: November 2022

OBJECTIVE
Dosimetric radiosurgery incidents are rare and probably insufficiently reported in scientific publications. After a long follow-up (FU), the authors studied the outcomes of patients treated with overexposure radiation for arteriovenous malformation (AVM) administered via stereotactic radiosurgery (SRS) at their department.

METHODS
Between May 2006 and June 2007, 22 patients were treated for AVM with SRS. The mean (range) patient age was 43.5 (11.8–78) years. Previous treatments were embolization (n = 10), SRS (1), and surgery (1). The average (range) volume was 2.1 (0.2–6.4) cm3. The median prescribed minimal dose was 18.0 Gy. An initial error in the estimation of scatter factors led to overexposure to radiation. Due to this incident, the median delivered minimum dose was 25.0 Gy. All patients were prospectively followed with clinical examination and imaging.

RESULTS
The mean (range) clinical FU was 14.5 (12.0–15.2) years. AVM obliteration after SRS was completed in 90.9% of patients at a mean (range) of 39.4 (24.4–70.4) months. No patient had post-SRS AVM bleeding. Three patients (13.6%) had new permanent deficits due to radiation-induced changes (RICs). Obliteration without new deficits was achieved in 18 patients (81.8%). Two patients had new epilepsy that was probably due to RIC but well controlled. The median (range) MRI FU was 13.8 (2.5–14.9) years. During MRI FU, two RIC periods were observed: one classic period during the first 3 years showed T1-weighted annular irregular enhancement (13%), and the other period between 5 and 15 years after SRS showed the occurrence of cystic and hemorrhagic lesions (22.7%). There were no cases of radiation-induced tumor.

CONCLUSIONS
The present long-term report showed that this overexposure incident probably increased the AVM obliteration rate. This overexposure seems to have induced RIC and in particular a higher rate of cystic and hemorrhagic late lesions with nevertheless moderate clinical consequences. Long-term FU for AVM is mandatory due to the risk of late RIC.
Stereotactic radiosurgery and local control of brain metastases from triple-negative breast cancer
Authors: Kowalchuk Roman O. , Niranjan Ajay , Hess Judith , Antonios Joseph P. , Zhang Michael Y. , Braunstein Steve , Ross Richard B. , Pikis Stylianos , Deibert Christopher P. , Lee Cheng-chia , Yang Huai-che , Langlois Anne-Marie , Mathieu David , Peker Selcuk , Samanci Yavuz , Rusthoven Chad G. , Chiang Veronica , Wei Zhishuo , Lunsford L. Dade , Trifiletti Daniel M. , Sheehan Jason P. 
Published: November 2022

OBJECTIVE
Stereotactic radiosurgery (SRS) is an effective treatment for intracranial metastatic disease, but its role in triple-negative breast cancer requires further study. Herein, the authors report overall survival (OS) and local tumor control in a multiinstitutional cohort with triple-negative breast cancer metastases treated with SRS.

METHODS
Patients treated from 2010 to 2019 at 9 institutions were included in this retrospective study if they had biopsy-proven triple-negative breast cancer with intracranial metastatic lesions treated with SRS. Patients were excluded if they had undergone prior SRS, whole-brain radiation therapy, or resection of the metastatic lesions. A retrospective chart review was conducted to determine OS, local control, and treatment efficacy.

RESULTS
Sixty-eight patients with 315 treated lesions were assessed. Patients had a median Karnofsky Performance Status of 80 (IQR 70–90) and age of 57 years (IQR 48–67 years). Most treated patients had 5 or fewer intracranial lesions, with 34% of patients having a single lesion. Treated lesions were small, having a median volume owf 0.11 cm3 (IQR 0.03–0.60 cm3). Patients were treated with a median margin dose of 18 Gy (IQR 18–20 Gy) to the median 71% isodose line (IQR 50%–84%). Overall, patients had a 1-year OS of 43% and 2-year OS of 20%. Most patients (88%) were followed until death, by which time local tumor progression had occurred in only 7% of cases. Furthermore, 76% of the lesions demonstrated regression. Tumor volume was correlated with local tumor progression (p = 0.012). SRS was very well tolerated, and only 3 patients (5%) developed symptomatic radiation necrosis.

CONCLUSIONS
SRS is a safe and efficacious treatment for well-selected patients with triple-negative breast cancer, especially for those with a favorable performance status and small- to moderate-volume metastatic lesions.
Interhospital transfer of pediatric patients with malignant brain tumor not associated with increased mortality, but safe routine discharge
Authors: Rangwala Shivani D. , Han Jane S. , Ding Li , Mack William J. , Krieger Mark D. , Attenello Frank J. 
Published: November 2022

OBJECTIVE
Interhospital transfer (IHT) to obtain a higher level of care for pediatric patients requiring neurosurgical interventions is common. Pediatric patients with malignant brain tumors often require subspecialty care commonly provided at specialized centers. The authors aimed to assess the impact of IHT in pediatric neurosurgical patients with malignant brain tumors to identify areas of improvement in treatment of this patient population.

METHODS
Pediatric patients (age < 19 years) with malignant primary brain tumors undergoing craniotomy for resection between 2010 and 2018 were retrospectively identified in the Nationwide Readmissions Database. Patient and hospital data for each index admission provided by the Nationwide Readmissions Database was analyzed by univariate and multivariate analyses. Further analysis evaluated association of IHT on specific patient- or hospital-related characteristics.

RESULTS
In a total of 2279 nonelective admissions for malignant brain tumors in pediatric patients, the authors found only 132 patients (5.8%) who underwent IHT for a higher level of care. There is an increased likelihood of transfer when a patient is younger (< 7 years old, p = 0.006) or the disease process is more severe, as characterized by higher pediatric complex chronic conditions (p = 0.0004) and increased all patient refined diagnosis-related group mortality index (p = 0.02). Patients who are transferred (OR 1.87, 95% CI 1.04–3.35; p = 0.04) and patients who are treated at pediatric centers (OR 6.89, 95% CI 4.23–11.22; p < 0.0001) are more likely to have a routine discharge home. On multivariate analysis, transfer status was not associated with a longer length of stay (incident rate ratio 1.04, 95% CI 0.94–1.16; p = 0.5) or greater overall costs per patient ($20,947.58, 95% CI −$35,078.80 to $76,974.00; p = 0.50). Additionally, IHT is not associated with increased likelihood of death or major complication.

CONCLUSIONS
IHT has a significant role in the outcome of pediatric patients with malignant brain tumors. Transfer of this patient population to hospitals providing subspecialized care results in a higher level of care without a significant burden on overall costs, risks, or mortality.
Intrauterine closure of myelomeningocele defects with primary linear repair versus bipedicle fasciocutaneous flaps: a post-MOMS cohort study with long-term follow-up
Authors: Pontell Matthew E. , Yengo-Kahn Aaron M. , Taylor Emily , Kane Morgan , Newton J Michael , Bennett Kelly A. , Wellons John C. , Braun Stephane A. 
Published: November 2022

OBJECTIVE
The objective of this study was to determine the effects of in utero bipedicle flaps on maternal-fetal morbidity/mortality, the need for CSF diversion, and long-term functional outcomes.

METHODS
Eighty-six patients who underwent fetal myelomeningocele repair from 2011 to 2021 at a single institution were reviewed. Primary outcomes included intrauterine fetal demise, postnatal death, postnatal myelomeningocele repair dehiscence, and CSF diversion by final follow-up.

RESULTS
The cohorts were no different with regard to race, ethnicity, maternal age at fetal surgery, body mass index, gravidity, parity, gestational age at fetal surgery, estimated fetal weight at fetal surgery, or fetal lesion level. Of the 86 patients, 64 underwent primary linear repair and 22 underwent bipedicle flap repair. There were no significant differences in rates of intrauterine fetal demise, postnatal mortality, midline repair site dehiscence, or the need for CSF diversion by final follow-up. Operative times were longer (32.5 vs 18.7 minutes, p < 0.001) and gestational age at delivery was lower (232 vs 241 days, p = 0.01) in the bipedicle flap cohort, but long-term functional outcomes were not different.

CONCLUSIONS
Analysis of the total cohort affirms the long-term benefits of fetal myelomeningocele repair. In utero bipedicle flaps are safe and can be used for high-tension lesions without increasing perioperative risks to the mother or fetus. In utero flaps preserve the long-term benefits seen with primary linear repair and may expand inclusion criteria for fetal repair, providing life-changing care for more patients.
Pengenalan dan Praktik Saham Berbasis Syariah Sebagai Pilihan Investasi Di Tengah Pandemi Kepada Guru-guru MTs N 4 Karawang
Authors: Diana Nana , Kristamtomo Putra Raden Aditya , Ridha Azhari 
Published: November 2022

Data lima tahun terakhir (2015-2019), jumlah saham syariah terus mengalami peningkatan dari tahun ke tahun. Jumlah saham syariah pada tahun 2015 sebanyak 331 saham. Data per periode 1 tahun 2020 jumlah saham syariah mencapai 470 saham. Pelatihan dan praktik ini dilakukan secara daring kepada guru-guru MTs N 4 Karawang. Dilakukan survei melalui googleform setelah kegiatan berlangsung. Sebelum adanya webinar praktik saham syariah statistik pengetahuan peserta adalah 34% dari peserta menyatakan berada di rentang 1. 24% peserta menyatakan berada di rentang 2. 19% peserta menyatakan berada di rentang 3. 7% peserta menyatakan berada di rentang 4. Serta 16% peserta menyatakan berada di rentang 5. Sedangkan setelah adanya webinar praktik saham syariah menghasilkan hasil perbedaan yang cukup signifikan yaitu 3% dari peserta menyatakan berada di rentang 1 dan juga rentang 2. 24% peserta menyatakan berada di rentang 3. 44% peserta menyatakan berada di rentang 4. Serta 26% peserta menyatakan berada di rentang 5. Hasil dari kusioner survei peserta rangkaian webinar saham syariah tersebut menjelaskan bahwa adanya dampak yang cukup signifikan untuk pengedukasian kepada Guru MTs 4 Negeri Karawang, mahasiswa, dan masyarakat umum sebagai peserta dari rangkaian webinar mengenai pengenalan dasar teori dan implementasi transaksi saham syariah.
Pemanfaatan E-Commerce dan Sistem Informasi Akuntansi Pada Usaha UMKM Pasca Pandemi Covid 19 Di Desa Dukuh Dempok, Kec. Wuluhan, Jember
Authors: Suharsono Riyanto Setiawan , Azhad Naely , Santoso Budi 
Published: November 2022

The development of science and technology through the use of E-Commerce and Accounting Information Systems in the business world, especially in Micro, Small and Medium Enterprises (MSMEs) has increased in recent years. E-Commerce which is a buying and selling activity through electronic media allows it to be carried out by business actors and the public even though they have limited capital. The financing network, business network as well as MSME business competition which are quite extensive and growing also require adequate Accounting Information System facilities to collect transaction data, make decisions and supervise the organization. The ability to absorb labor from MSMEs is also quite large. This makes MSMEs have an important role in the economy of a region. The emergence of the Covid-19 Pandemic in early 2020, whose impact is still being felt in 2021, has raised various problems due to reduced income for most people in general. All MSME sectors are affected by the Covid-19 Pandemic. For this reason, innovations are needed in increasing people's income through the use of E-Commerce and Accounting Information Systems to increase the business potential of MSMEs.
This Service Program seeks to provide answers and solutions to problems faced by some small communities and MSME business actors who are affected by the Covid-19 Pandemic and are not familiar with technological developments. Based on the problems faced by the community, the service that will be carried out is to provide training and education to the community and MSME actors in Dukuh Dempok Village, Kec. Wuluhan, Jember. This community service method uses seminars/workshops, practices and discussions with MSME actors in Dukuh Dempok Village, Kec. Wuluhan, Jember
Teknologi SMAW Untuk Kebutuhan Proses Fabrikasi Produk Bidang Pengelasan Pada Masyarakat Pedesaan di Sektor Pertanian
Authors: Noorsakti Wahyudi  , Alfi Tranggono Agus Salim  , Yosi Afandi  , Imam Mudofir  , Wida Yuliar Rezika  , Nurudin  , Tania Setya Ningsih  , Rafael Slamet Firdaus  , Mega Rahayu Nur Kusuma Wardhani  
Published: November 2022

Abstrak

Pertanian adalah sektor utama di Desa Bader, Dusun Kayang Makmur, Kabupaten Dolopo, khususnya pada RT 16, RW 06. Alat bantu pertanian mayoritas berbahan logam yang dapat aus, korosi, dan patah. Kerusakan/patah pada alat pertanian berbahan logam, seperti cangkul, bajak, dan sabit lebih efektif dilakukan perbaikan dengan pengelasan SMAW Aplikatif. Kerusakan alat pertanian umumnya bisa diposisikan secara horizontal karena bisa dilepas dari komponen lainnya, sehingga posisi pengelasan yang mudah dan sesuai adalah 1F dan 2F. Penerapan teknologi bidang pengelasan dilakukan secara teori dan praktek dalam kegiatan Program Kemitraan Masyarakat (PKM). Metode pelatihan mengadopsi dari IPTEK yang diterapkan pada perkuliahan di Politeknik Negeri Madiun. Pengabdian untuk menghasilkan luaran peserta yang mampu memperbaiki alat pertanian berbahan logam, dan membuat produk berbahan dasar logam dengan proses pengelasan SMAW.

Kata kunci— Dusun Kayang Makmur, Pertanian, Pengelasan Aplikatif, SMAW, Program Kemitraan Masyarakat
Terapan Metode Pengelasan Dasar GMAW Gasless untuk Peningkatan Keterampilan Masyarakat Dusun Kayang Makmur, Desa Bader, Kabupaten Madiun
Authors: Alfi Tranggono Agus Salim  , Achmad Aminudin  , Nanang Romandoni  , Muhamad Fajar Subkhan  , Fachrudin Muhamad Rizki Fachrudin , Radiffa Aditama  , Mochamad Reza Arimurti  , Elza Febri Yusdetira  
Published: November 2022

Abstrak
Masyarakat Dusun Kayang Makmur sebagian besar telah menggunakan peralatan pertanian yang terbuat dari baja. Alat pertanian tersebut dibutuhkan perawatan dan perbaikan dengan menggunakan teknik pengelasan. Dalam melakukan pengelasan tersebut harus dilakukan sesuai dengan prosedur pengelasan yang benar, instalasi alat yang tepat, dan pemahaman yang baik mengenai Keselamatan dan Kesehatan Kerja (K3) sehingga efektivitas dari pengelasan dapat dicapai dengan maksimal. Oleh karena itu, diadakan pelatihan pengelasan dasar GMAW Gasless guna meningkatkan keterampilan Masyarakat Dusun Kayang Makmur. Penyelenggaraan program kemitraan masyarakat ini dilaksanakan dengan beberapa parameter dengan luaran dari kegiatan ini berupa kemampuan teknik pengelasan dasar GMAW Gasless metode 1F dan 2F. Tahapan pelaksanaan terdiri dari teori pengelasan, K3, serta praktek dan pendampingan pengelasan dasar yang menghasilkan produk berupa kursi. Hasil dari pengabdian pengelasan ini adalah peningkatan pengetahuan dan kemampuan peserta hal pengelasan dasar GMAW Gasless, serta dapat menerapkan proses pengelasan dengan mengutamakan K3.

Kata Kunci- Program Kemitraan Masyarakat, Dusun Kayang Makmur, Pengelasan, GMAW Gasless.
The Perception and Resilience of Bagang Community on Climate Change in Marine Protected Area, Pitas, Sabah, Malaysia
Authors: FOO JURRY 
Published: November 2022

Climate change had caused occurrence of more frequent big El Nino and La Nino phenomenon that led to drought and flood disasters onto coastal communities and affecting their quality of life. This study aims to ascertain the perceptions of the coastal community of Kampung Mempakad Laut, Pitas, Sabah, Malaysia which is in the boundary of Tun Mustapha Park on climate change. Data is collected through in-depth interviews with the Bagang community and the data was analysed by descriptive methods. The Bagang community members have knowledge and is aware of the changes in the climate conditions through the happenings of extreme event orchestrated by mother nature that relates to the change in climate phenomena despite not knowing or not familiar with the well-used terms ‘climate change’. Examples of those extreme events are major floods, changes in dry and wet seasons, as well as long unpredictable dry season. They perceive those events as pressure that ultimately threatens their safety and affects Bagang activities. However, they have come up with their own strategies in adapting to the phenomena including precautionary and preparatory measures for enduring natural disasters, modifications of dwelling houses, attempts to increase understanding and cognisance of the changes in environmental surroundings enabling them to come up with better predictions. The experience and resilience of Bagang community that had endured extreme events related to climate change had provided further insights in understanding human’s adaptations to climate change and could become useful guidelines to other coastline communities at large.
Tamoxifen resistance-related ceRNA network for breast cancer
Authors: Qiao Zipeng , Xing Yu , Zhang Qingquan , Tang Yongjun , Feng Ruifa , Pang Weiyi 
Published: November 2022

Background: Tamoxifen (TMX) is one of the most widely used drugs to treat breast cancer (BC). However, acquired drug resistance is still a major obstacle to its application, rendering it crucial to explore the mechanisms of TMX resistance in BC. This aims of this study were to identify the mechanisms of TMX resistance and construct ceRNA regulatory networks in breast cancer.Methods: GEO2R was used to screen for differentially expressed mRNAs (DEmRNAs) leading to drug resistance in BC cells. MiRTarbase and miRNet were used to predict miRNAs and lncRNAs upstream, and the competing endogenous RNA (ceRNA) regulatory network of BC cell resistance was constructed by starBase. We used the Kaplan–Meier plotter and Gene Expression Profiling Interactive Analysis (GEPIA) to analyze the expression and prognostic differences of genes in the ceRNA network with core axis, and qRT-PCR was used to further verify the above conclusions.Results: We found that 21 DEmRNAs were upregulated and 43 DEmRNA downregulated in drug-resistant BC cells. DEmRNAs were noticeably enriched in pathways relevant to cancer. We then constructed a protein-protein interaction (PPI) network based on the STRING database and defined 10 top-ranked hub genes among the upregulated and downregulated DEmRNAs. The 20 DEmRNAs were predicted to obtain 113 upstream miRNAs and 501 lncRNAs. Among them, 7 mRNAs, 22 lncRNAs, and 11 miRNAs were used to structure the ceRNA regulatory network of drug resistance in BC cells. 4 mRNAs, 4 lncRNAs, and 3 miRNAs were detected by GEPIA and the Kaplan–Meier plotter to be significantly associated with BC expression and prognosis. The differential expression of the genes in BC cells was confirmed by qRT-PCR.Conclusion: The ceRNA regulatory network of TMX-resistant BC was successfully constructed and confirmed. This will provide an important resource for finding therapeutic targets for TMX resistance, where the discovery of candidate conventional mechanisms can aid clinical decision-making. In addition, this resource will help discover the mechanisms behind this type of resistance.
Biochemical and in silico inhibition of bovine and human carbonic anhydrase-II by 1H-1,2,3-triazole analogs
Authors: Khan Majid , Avula Satya Kumar , Halim Sobia Ahsan , Waqas Muhammad , Asmari Mufarreh , Khan Ajmal , Al-Harrasi Ahmed 
Published: November 2022

A series of 1H-1,2,3-triazole analogs (7a–7d and 9a–9s) were synthesized via “click” chemistry and evaluated for in vitro carbonic anhydrase-II (bovine and human) inhibitory activity. The synthesis of intermediates, 7a and 7c, was achieved by using (S)-(-)ethyl lactate as a starting material. These compounds (7a and 7c) underwent Suzuki–Miyaura cross-coupling reaction with different arylboronic acids in 1,4-dioxane, reflux at 90–120°C for 8 h using Pd(PPh3)4 as a catalyst (5 mol%), and K2CO3 (3.0 equiv)/K2PO4 (3.0 equiv) as a base to produce target 1H-1,2,3-triazole molecules (9a–9s) for a good yield of 67–86%. All the synthesized compounds were characterized through NMR spectroscopic techniques. Furthermore, all those compounds have shown significant inhibitory potential for both sources of carbonic anhydrase-II (CA-II). In the case of bCA-II, compounds 9i, 7d, 9h, 9o, 9g, and 9e showed potent activity with IC50 values in the range of 11.1–17.8 µM. Whereas for hCA-II, compounds 9i, 9c, 9o, and 9j showed great potential with IC50 values in the range of 10.9–18.5 µM. The preliminary structure–activity relationship indicates that the presence of the 1H-1,2,3-triazole moiety in those synthesized 1H-1,2,3-triazole analogs (7a–7d and 9a–9s) significantly contributes to the overall activity. However, several substitutions on this scaffold affect the activity to several folds. The selectivity index showed that compounds 9c, 9k, and 9p are selective inhibitors of hCA-II. Kinetics studies showed that these compounds inhibited both enzymes (bCA-II and hCA-II) in a competitive manner. Molecular docking indicates that all the active compounds fit well in the active site of CA-II. This study has explored the role of 1H-1,2,3-triazole-containing compounds in the inhibition of CA-II to combat CA-II-related disorders.