bluuebunny/crossref_metadata_2025_split huggingface dataset:
Realita Gamifikasi Pada Perusahaan
Authors: Benita Nathania Agatha 
Published: February 2022

Beberapa organisasi memiliki budaya, tujuan atau visi dan gaya manajemen yang berbeda, demikian juga dengan perusahaan. Untuk membentuk budaya mereka atau mencapai tujuan mereka, manajemen membuat beberapa aturan untuk internal dan eksternal perusahaan. Mereka berharap orang-orang akan mematuhi aturan itu, dan menjadi kebiasaan mereka. Beberapa perusahaan membuat beberapa aturan menjadi gaya permainan. Terkadang untuk membuat beberapa aturan berhasil diterapkan, manajer memberikan hukuman kepada yang melanggar aturan itu, dan beberapa manajer memberikan penghargaan kepada yang menerapkan aturan dengan baik. Penggunaan reward dan punishment sebagai bagian dari gamification. Tujuan dari penelitian ini adalah untuk menilai faktor keberhasilan dan kegagalan implementasi gamifikasi. Untuk menilai mereka, penulis mewawancarai karyawan dari PT.A, PT.B, PT.C dan PT.D yang telah bekerja lebih dari 2 tahun. PT. A dan PT.B adalah perusahaan jasa, PT.C dan PT.D adalah perusahaan manufaktur. Hasil penelitian ini menunjukkan adanya perbedaan pengelolaan gamifikasi pada objek penelitian, dan terdapat perbedaan hasil pelaksanaan gamifikasi karena beberapa faktor yang berbeda.
Effect of Endogenous and Exogenous Butyric Acid on Butanol Production From CO by Enriched Clostridia
Authors: He Yaxue , Lens Piet N. L. , Veiga María C. , Kennes Christian 
Published: February 2022

Butanol is a potential renewable fuel. To increase the selectivity for butanol during CO fermentation, exogenous acetic acid and ethanol, exogenous butyric acid or endogenous butyric acid from glucose fermentation have been investigated using CO as reducing power, with a highly enriched Clostridium sludge. Addition of 3.2 g/L exogenous butyric acid led to the highest 1.9 g/L butanol concentration with a conversion efficiency of 67%. With exogenous acetate and ethanol supply, the butanol concentration reached 1.6 g/L at the end of the incubation. However, the presence of acetic acid and ethanol favoured butanol production to 2.6 g/L from exogenous butyric acid by the enriched sludge. Finally, exogenous 14 g/L butyric acid yielded the highest butanol production of 3.4 g/L, which was also among the highest butanol concentration from CO/syngas fermentation reported so far. CO addition triggered butanol production from endogenous butyric acid (produced from glucose, Glucose + N2) with as high as 58.6% conversion efficiency and 62.1% butanol yield. However, no efficient butanol production was found from glucose and CO co-fermentation (Glucose + CO), although a similar amount of endogenous butyric acid was produced compared to Glucose + N2. The Clostridium genus occupied a relative abundance as high as 82% from the initial inoculum, while the Clostridia and Bacilli classes were both enriched and dominated in Glucose + N2 and Glucose + CO incubations. This study shows that the supply of butyric acid is a possible strategy for enhancing butanol production by CO fed anaerobic sludge, either via exogenous butyric acid, or via endogenous production by sugar fermentation.
The Compression Behavior of Undisturbed and Compacted Loess Under the Controlling of Total Suction and Injected Solutions
Authors: Zhang Tongwei , Hu Zhengjin , Lan Hengxing , Deng Yongfeng , Zhang Huyuan 
Published: February 2022

Thousands of square kilometers of habitable land have been created on the Loess Plateau in China. In arid and semi-arid area of Northwest China, the mechanical behavior of structural loess is sensitive to water intrusion and human engineering activities. Meanwhile, the higher water salinity in loess and seasonal variation of ambient humidity are common in this area. Due to different physical and mechanical properties of natural and compacted loess, the impacts of ambient humidity and saline water migration on their deformation are still unclear. This paper developed an oedometer test to investigate the compression behavior of natural and compacted loess under environmental humidity (represented by total suction Ψ) and injection water salinity (represented by osmotic suction Ψπ) changing. The results showed that the void ratio variation Δe of compacted loess (the dry density is 1.8 g/m3) under the impact of total suctions (from 14.01 to 146.23 MPa) and salinities of injected solution (0.17 mol/L NaCl, 0.29 mol/L Na2SO4 and distilled water) were under 0.01. The variation of void ratio for undisturbed loess increased about 8 times with 10 times decreasing of total suction, which was corresponding to the increase of relative humidity (RH). In the stage of solution injection, the deformation of undisturbed loess increased with the Ψ-Ψπ increasing, and the differences between different samples reached to nearly 20 times. The mechanism was that the salt inside undisturbed loess would deliquescence when the RH was higher than DRH (Deliquescence Relative Humidity), and the natural structure collapsed. The compression index Cc of samples generally decreased with Ψ-Ψπ, and the compressibility of undisturbed loess was higher. The swelling indices Cs of samples slightly decreased with Ψ-Ψπ, but the variation was not significant. The strain-stress relationships of loess can be well described by Duncan-Chang constitutive model. Interestingly, the difference of initial deformation modulus ΔEs of two loesses, which represented the structural compression under the coupling of total suction and osmotic suction, linearly related to the Ψ-Ψπ. The Δεmax between the structural loess and compacted loess exponential increased with Ψ-Ψπ. In the engineering practice, the humidity and saline water intrusion should be considered in the long-term behavior of loess in shallow layer.
Tropical South American Rainfall Response to Dansgaard-Oeschger Stadials of Marine Isotope Stage 5
Authors: Venancio Igor M. , Nascimento Rodrigo A. , Santos Thiago P. , Belem Andre L. , Lessa Douglas O. , Tiedemann Ralf , Chiessi Cristiano M. , Mulitza Stefan , Albuquerque Ana Luiza S. 
Published: February 2022

Tropical precipitation patterns will most likely be altered by future climate change, with major socioeconomic consequences for human populations that are highly reliant on water availability for subsistence like populations in northeastern (NE) Brazil. Socioeconomic consequences may be particularly disruptive in the occurrence of abrupt climate change. Understanding the response of tropical precipitation to abrupt climate change is a crucial task for improving future projections and devising adaptation policies. Past abrupt climate change events such as the Dansgaard-Oeschger (DO) cycles may provide relevant insights regarding the dynamics of the climate system under this type of climate change. Here we present a paleoceanographic reconstruction off NE Brazil based on geochemical analyses (stable oxygen isotopes, Mg/Ca and Ba/Ca) performed in planktonic foraminifera, that focus on DO stadials of Marine Isotope Stage 5 (MIS5, 130–71 ka). Our new Ba/Ca record shows increases in fluvial discharge linked to enhanced continental precipitation over NE Brazil during DO stadials of MIS5. Tropical precipitation patterns were altered with enhanced rainfall in NE Brazil during DO stadials as a consequence of a southward displacement of the Intertropical Convergence Zone, which, in turn, was likely a response to changes in ocean heat transport and sea ice cover, as highlighted by recent climate model simulations. The results presented here provide useful information on how abrupt climate change can impact tropical rainfall, which is crucial for tropical societies in order to delineate strategies to cope with future climate change.
The Structure and Elasticity of CaO3 Under High Pressure by First-Principles Simulation
Authors: Wang Hanyu , Liu Lei , Yang Longxing , Sun Fengxia , Yi Li , Liu Hong 
Published: February 2022

The structure, electrical properties, elasticity, and anisotropy of the newly discovered mantle mineral, CaO3, are obtained under 10–50 GPa by first-principles simulation to understand their relations with the composition and structure of the mantle transition zone. Crystal structure and phonon frequencies under 0–50 GPa indicate that CaO3 can exist stably under 10–50 GPa. Here, the band gap of CaO3 is 2.32–2.77 under the explored pressure and indicates its semiconductor property. The Mulliken population analysis shows that the Ca–O bond is an ionic bond, and O–O bond is a covalent bond, and the strength of the O–O bond is higher than that of the Ca–O bond. The density, bulk modulus, and shear modulus of CaO3 increase with increasing pressure. The compressional wave velocity (Vp) and shear wave velocity (Vs) of CaO3 increase with increasing pressure. The seismic wave velocity of CaO3 is smaller than that of the Preliminary Reference Earth Model (PREM) and common mantle transition zone minerals, and it is a very exceptional low seismic wave velocity phase. The anisotropies of Vs are 36.47, 26.41, 23.79, and 18.96%, and the anisotropies of Vp are 18.37, 13.91, 12.75, and 10.64% under 15, 25, 35, and 50 GPa, respectively. Those seismic velocity anisotropies are larger than those of the mantle transition zone’s main component, so CaO3 may be an important source of seismic wave velocity anisotropy in the mantle transition zone. Our results provide new evidence for understanding the material composition and the source of anisotropy in the mantle transition zone.
Predicting Sugar Balance as the Impact of Land-Use/Land-Cover Change Dynamics in a Sugarcane Producing Regency in East Java, Indonesia
Authors: Artikanur Salis Deris , Widiatmaka Widiatmaka , Setiawan Yudi , Marimin Marimin 
Published: February 2022

Lamongan Regency is one of Indonesia’s regencies in Indonesia that contribute to the country’s sugarcane and sugar production. Land-use/land-cover changes (LULC) have happened in various areas, including Lamongan Regency in East Java, Indonesia. This study aimed to analyze the impact of land-use/land-cover change (LULCC) in 2007–2031 on the sugar balance in the Lamongan Regency in 2031. The LULC forecast in 2031 was made using R studio using the CLUE-s function in the LULCC package. Following that, the sugar requirements and sugar balance in Lamongan Regency in 2031 were forecasts. The kappa accuracy of the LULC model tested in 2019 was 0.81 when using the CLUE-s model in R studio’s LULCC package. The findings of the LULC prediction in Lamongan Regency for 2031 indicated that there could be significant changes in LULC, resulting in an estimated reduction in 1,687.5 ha sugarcane, influenced by LULC competition for built-up areas. The Built-up areas in Lamongan Regency have exploded in size as a result of population. An increase in built-up areas and a reduction in sugarcane plantations as a result of LULCC are expected to diminish the sugar balance in Lamongan Regency by 10,470.76 tons in 2031 when compared to 2019. The results of this study can be utilized to prevent uncontrolled LULCC in the future to meet sugar needs in Lamongan Regency and at the national level.
Neuromuscular Electrical Stimulation in Patients With Severe COVID-19 Associated With Sepsis and Septic Shock
Authors: Righetti Renato Fraga , Grams Samantha Torres , Costa Wesla Neves da Silva , Saraiva Leandro Teixeira , Salles Isabel Chateaubriand Diniz de , Yamaguti Wellington Pereira 
Published: February 2022

BackgroundNeuromuscular electrical stimulation (NMES) can be applied to critically ill patients. However, its results on muscle strength and functionality in patients with COVID-19 are unknown.ObjectiveEvaluate the effects of intervention with NMES on muscle mass and functionality of patients with severe COVID-19 associated with sepsis and septic shock.MethodsSeven patients with COVID-19 associated with sepsis or septic shock were selected, but only 5 patients completed all days of the intervention with NMES. The intervention was performed by a single physiotherapist on 7 consecutive days in a daily session of 40 min. The outcome measures were the femoris cross-sectional area; thickness of the anterior compartment of the quadriceps muscle; rectus femoris echogenicity; International Classification of Functioning, Disability, and Health (ICF)-muscle strength; PFIT-s, DEMMI, and the SOMS; feasibility, and safety. The patients were evaluated on days 1, 5, and 8.ResultsThe rectus femoris cross-sectional area decreased significantly from days 1 to 8, but showed maintenance of the thickness of the anterior compartment of the quadriceps muscle from days 1 to 8. The MRC score increased significantly from days 1 to 5 and kept this improvement until day 8. All patients showed an increase in the MRC score and reduction of the ICF-muscle strength, meaning improved muscle strength from days 1 to 8. The PFIT-s increased significantly from days 1 to 5 and improved until day 8 compared to day 5. DEMMI and SOMS score increased significantly on day 8 compared to days 1 and 5.ConclusionRehabilitation with NMES showed improvement in muscle strength and functionality of patients in this study with a potential protective effect on muscle mass loss in patients with critical COVID-19 associated with sepsis and septic shock. This study is the first report of the potential effects of neuromuscular electrical stimulation in patients with severe COVID-19 associated with sepsis and septic shock.
Efficacy of Intravitreal Injection of Filtered Modified Low-Dose Triamcinolone Acetonide and Ranibizumab on Pseudophakic Cystoid Macular Edema
Authors: Tariq Farheen , Wang Yanfen , Ma Bo , He Yidan , Zhang Shu , Bai Ling 
Published: February 2022

PurposeTo compare the visual and morphological effects between intravitreal injection of filtered modified 2 mg triamcinolone acetonide (TA) and 0. 5 mg ranibizumab in patients with pseudophakic cystoid macular edema (PCME).MethodsA retrospective, interventional study was conducted from January 2015 to February 2020 involving patients with PCME after uneventful cataract surgery. A total of 25 patients (25 eyes) with PCME received an intravitreal injection of 0.22 μm filtered modified 2 mg TA, while 15 patients (15 eyes) received 0.5 mg ranibizumab injection. Central macular thickness (CMT), best-corrected visual acuity (BCVA), intraocular pressure (IOP), times of repeated injections, and other side effects were observed at 2 weeks, 1 month, 3 months, and 6 months after injection; then, the data were compared with preinjection information in each group and between the two groups.ResultsBoth the TA and ranibizumab intravitreal injection can achieve improved BCVA and reduced CMT in patients with PCME (P &lt; 0.05), with a trend toward greater improvement in the TA group, but the difference was only significant at 3 months (P &lt; 0.05). IOP was in the normal range without any significant difference (P &gt; 0.05). Thirty-three percent of patients in the ranibizumab group required repeated intravitreal injection compared to 4% in the TA group. Further stratified analysis showed that the better therapeutic effect of the TA group at 3 months after injection only existed in patients with diabetes mellitus (DM), while not in patients without DM. There was no repeat injection in the TA group and 12.5% in the ranibizumab group for patients without DM, while 16.7% in the TA group and 57.1% in the ranibizumab group required repeated injection for patients with DM, which had a significant difference (P &lt; 0.05).ConclusionIntravitreal injection of filtered modified 2 mg TA is safe, effective, and an inexpensive alternative to antivascular endothelial growth factor (anti-VEGF) agents for patients with PCME, especially for patients concurrently with DM. A large number of clinical randomized controlled studies along with long-term follow-up observations are needed.
High Frequency of Post-Transfusion Microchimerism Among Multi-Transfused Beta-Thalassemic Patients
Authors: Matsagos Spyridon , Verigou Evgenia , Kourakli Alexandra , Alexis Spyridon , Vrakas Spyridon , Argyropoulou Constantina , Lazaris Vasileios , Spyropoulou Panagiota , Labropoulou Vasiliki , Georgara Nicoletta , Lykouresi Maria , Karakantza Marina , Alepi Chrysoula , Symeonidis Argiris 
Published: February 2022

BackgroundTransfusion-associated microchimerism implies the presence of allogeneic hematopoietic cells in an individual, following the transfusion of a blood product. It is a transfusion-related adverse effect/long-term consequence, which has not been well-investigated among regularly transfused patients with thalassemia.Patients and MethodsWe investigated 64 regularly transfused, homozygous β-thalassemic patients and 21 never-transfused healthy volunteer blood donors (controls) for the presence of microchimerism in their sera, using real-time PCR targeting circulating allogeneic, both, Human Leukocyte Antigen-DR isotype (HLA-DR) and non-HLA alleles. The investigation was longitudinally repeated in patient subsets for more than 2 years. Results were correlated with clinical and laboratory parameters, peripheral blood lymphocyte immunophenotype, blood storage time, and donor's gender to identify potential contributing factors for microchimerism generation.ResultsOverall, microchimerism was detected in 52 of the 64 patients (81.2%) and in 6 of the 21 controls (28.5%, p = 0.0001). Forty-four patients (68.7%) exhibited long-term microchimerism (persisted for more than 6 months), confirmed at all time-points investigated. Microchimerism was more frequent among elderly, women, splenectomized and more heavily transfused patients, and among those who exhibit higher serum ferritin levels. In these patients, a distinct descending pattern of CD16dim+CD56dim+ natural killer (NK)-cells (p &lt; 0.001) and an ascending pattern of CD4+CD25brightCD127– regulatory T-cells (p = 0.022) for increasing allelic burden were noticed, suggesting the establishment of recipient immune tolerance against the donor-derived chimeric alleles. Both splenectomized and non-splenectomized thalassemic patients exhibited the same trend. The storage time of transfused blood products and donor/gender mismatch had no impact on the development of microchimerism.Discussion-Conclusive RemarksTransfusion-associated microchimerism appears to be a very common complication among multi-transfused thalassemic patients. The potential clinical consequences of this phenomenon remain as yet unclear. Immune tolerance attributed to disease itself and to repeated transfusions might at least in part explain its appearance.
Decreased Netrin-1 in Mild Cognitive Impairment and Alzheimer’s Disease Patients
Authors: Ju Ting , Sun Lina , Fan Yuwei , Wang Tianhang , Liu Yanchen , Liu Dan , Liu Tianyi , Zhao Chang , Wang Wenxin , Chi Lijun 
Published: February 2022

Background and ObjectiveInflammatory mediators are closely associated with the pathogenesis of Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Netrin-1 is an axon guidance protein and despite its capacity to function as a neuroimmune guidance signal, its role in AD or MCI is poorly understood. In addition, the association among netrin-1, cognitive impairment and serum inflammatory cytokines such as interleukin-17 (IL-17) and tumor necrosis (TNF-α) remains unclear. The aim of this study was to determine serum levels of IL-17, TNF-α and netrin-1in a cohort of AD and MCI patients, and to study the relationship between these cytokines and cognitive status, as well as to assess the possible relationships between netrin-1 levels and inflammatory molecules.MethodsSerum concentrations of netrin-1, TNF-α and IL-17 were determined in 20 AD patients, 22 MCI patients and 22 healthy controls using an enzyme-linked immunosorbent assay (ELISA). In addition, neuropsychological evaluations and psychometric assessments were performed in all subjects.ResultsSerum netrin-1 levels were decreased in AD and MCI patients and were positively correlated with Mini Mental State Examination (MMSE) scores. In contrast, serum TNF-α and IL-17 levels were elevated in AD and MCI cohorts and negatively correlated with MMSE scores. Serum netrin-1 levels were inversely related with TNF-α and IL-17 levels in AD, but not MCI, patients.ConclusionBased on the findings reported here, netrin-1 may serve as a marker for the early recognition of dementia and predict cognitive impairment.
Association of Ischemic Core Imaging Biomarkers With Post-Thrombectomy Clinical Outcomes in the MR CLEAN Registry
Authors: Koopman Miou S. , Hoving Jan W. , Kappelhof Manon , Berkhemer Olvert A. , Beenen Ludo F. M. , van Zwam Wim H. , de Jong Hugo W. A. M. , Dankbaar Jan Willem , Dippel Diederik W. J. , Coutinho Jonathan M. , Marquering Henk A. , Emmer Bart J. , Majoie Charles B. L. M. ,   for the MR CLEAN Registry Investigators
Published: February 2022

Background: A considerable proportion of acute ischemic stroke patients treated with endovascular thrombectomy (EVT) are dead or severely disabled at 3 months despite successful reperfusion. Ischemic core imaging biomarkers may help to identify patients who are more likely to have a poor outcome after endovascular thrombectomy (EVT) despite successful reperfusion. We studied the association of CT perfusion-(CTP), CT angiography-(CTA), and non-contrast CT-(NCCT) based imaging markers with poor outcome in patients who underwent EVT in daily clinical practice.Methods: We included EVT-treated patients (July 2016–November 2017) with an anterior circulation occlusion from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN) Registry with available baseline CTP, CTA, and NCCT. We used multivariable binary and ordinal logistic regression to analyze the association of CTP ischemic core volume, CTA-Collateral Score (CTA-CS), and Alberta Stroke Program Early CT Score (ASPECTS) with poor outcome (modified Rankin Scale score (mRS) 5-6) and likelihood of having a lower score on the mRS at 90 days.Results: In 201 patients, median core volume was 13 (IQR 5-41) mL. Median ASPECTS was 9 (IQR 8-10). Most patients had grade 2 (83/201; 42%) or grade 3 (28/201; 14%) collaterals. CTP ischemic core volume was associated with poor outcome [aOR per 10 mL 1.02 (95%CI 1.01–1.04)] and lower likelihood of having a lower score on the mRS at 90 days [aOR per 10 mL 0.85 (95% CI 0.78–0.93)]. In multivariable analysis, neither CTA-CS nor ASPECTS were significantly associated with poor outcome or the likelihood of having a lower mRS.Conclusion: In our population of patients treated with EVT in daily clinical practice, CTP ischemic core volume is associated with poor outcome and lower likelihood of shift toward better outcome in contrast to either CTA-CS or ASPECTS.