bluuebunny/crossref_metadata_2025_split huggingface dataset:
PSYCHOLOGICAL STATUS AND QUALITY OF LIFE OF PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE AND METABOLIC SYNDROME
Authors: Успенский Юрий Павлович , Гулунов Заурбек Хазбиевич 
Published: November 2022

В статье обсуждаются тревожно -депрессивные расстройства и качество жизни пациентов с гастроэзофагеальной рефлюксной болезнью на фоне метаболического синдрома. Рассмотрено также влияние модификации образа жизни и пищевых предпочтений на психологический статус и качество жизни у пациентов с гастроэзофагеальной рефлюксной болезнью и метаболическим синдромом в течение периода наблюдения (12 месяцев). Для реализации исследования выполнены общеклиническое, лабораторное и инструментальное обследования. Проводилось также анкетирование опросником для оценки качества жизни SF-36 и госпитальной шкалой тревоги и депрессии HADS. В результате проведенного исследования выяснилось, что у пациентов с гастроэзофагеальной рефлюксной болезнью при наличии метаболического синдрома преобладают тревога и депрессия по сравнению с пациентами с изолированным течением гастроэзофагеальной рефлюксной болезнью. При проведении проспективного наблюдения за пациентами отмечалось статистически значимое снижение тревожных и депрессивных состояний у пациентов с приверженностью к немедикаментозным мероприятиям по снижению массы тела и изменению характера питания.
The article discusses anxiety and depressive disorders and the quality of life of patients with gastroesophageal reflux disease, depending on the presence of metabolic syndrome. The influence of lifestyle modification and food preferences on the psychological status and quality of life in patients with gastroesophageal reflux disease and metabolic syndrome after a 12-month follow -up period was also considered. To implement the study, a general clinical, laboratory and instrumental examination was performed. Questionnaires were also conducted with the SF-36 quality of life questionnaire and the Hospital Anxiety and Depression Scale. As a result of the study, it turned out that in patients with gastroesophageal reflux disease in the presence of metabolic syndrome, a psychological examination revealed a predominance of anxiety and depression compared to patients with an isolated course of gastroesophageal reflux disease. When conducting prospective follow -up of patients, there was a statistically significant decrease in anxiety and depressive states in patients with adherence to non -drug measures to reduce body weight and change the nature of nutrition.
Hematological manifestations in celiac disease
Authors: Богданов Александр Николаевич , Волошин Сергей Владимирович , Кулибаба Татьяна Германовна 
Published: November 2022

Целиакия во многих случаях характеризуется внекишечными проявлениями, из которых наиболее часто встречаются гематологические манифестации. В обзоре представлен анализ литературы о частоте и диагностике у больных целиакией анемий вследствие дефицита железа, витамина В12 и фолиевой кислоты, тромботических и геморрагических осложнений, дефицита иммуноглобулина А, лимфом и другой гематологической патологии.
Celiac disease in many cases characterized as extraintestinal manifestations, of which most often hematological manifestation occur. The review presents an analysis of literature about frequency and diagnosis in celiac patient’s anemias due to iron deficiency, vitamin B12 and folate deficiency, thrombotic and hemorrhagic complications, immunoglobulin A deficiency, lymphomas and other hematological pathology.
ORAL MESALAZINE DRUGS FOR ULCERATIVE COLITIS: CURRENT CLINICAL PRACTICE
Authors: Успенский Юрий Павлович , Иванов Сергей Витальевич , Фоминых Юлия Александровна , Сарана Андрей Михайлович , Древаль Руслан Орестович 
Published: November 2022

В статье описана роль пероральных препаратов 5-аминосалициловой кислоты (5-АСК) в структуре базисной терапии язвенного колита согласно действующим клиническим рекомендациям. Показаны результаты актуальных эпидемиологических исследований, отражающих особенности применения пероральных препаратов 5-АСК в клинической практике в разрезе протяженности поражения толстой кишки, отмечена высокая частота использования монотерапии пероральными препаратами 5-АСК. Представлен спектр применяемых в настоящее время пероральных препаратов 5-АСК и их особенности, определяющие поступление действующего вещества в слизистую оболочку пораженных участков толстой кишки.
The article represents the role of oral 5-aminosalicylic acid(5-ASA) drugs in the structure of the basic therapy of ulcerative colitis according to current clinical guidelines. The results of current epidemiological studies reflecting the features of the use of oral preparations 5-ASA in clinical practice in the context of the length of colon lesions are presented, a high frequency of use of monotherapy with oral 5-ASA preparations were noted. The spectrum of currently used oral preparations 5-ASA and their features that determine the flow of the active substance into the mucous membrane of the affected areas of the colon are presented.
Analisis Kelayakan Battery 110 VDC Dalam Mengsuplai Pembebanan ( Studi Kasus Gardu Induk Perawang 150 kV )
Authors: Nurhadi Irvan 
Published: November 2022

Rectifier berfungsi sebagai penstransformasi dari tegangan AC ke tegangan DC. Permasalahan umumnya terletak di tegangan AC saat masuk ke recifier yaitu terjadinya gangguan trip di sisi trafo pemakaian sendiri (PS) pada gardu induk yang biasanya disebabkan karena terjadinya gangguan pada saluran transmisi ataupun gangguan pada transformator daya.Tujuan dilakukannya penelitian ini adalah guna mengetahui kondisi dan kelayakan baterai yang ada pada gardu induk perawang. Dari pengukuran tiap sel pada baterai 110 Vdc unit 1 bulan februari terlihat saat keadaan charge tegangan rata - ratanya senilai 1,40V, ketika keadaan discharge tegangan rata - ratanya senilai 1.29 V. lalu baterai unit 2 dalam keadaan charge tegangan rata -ratanya senilai 1,41 V sementara saat keadaan discharge tegangan rata - ratanya senilai 1,29 V. Dengan demikian menurut standar pengukuran PLN baterai yang baik dan layak memiliki tegangan 1,30 V hingga 1,450 V ketika charge sementara keadaan discharge baterai yang layak memiliki tegangan 1,10 V hingga 1,25 V. maka dinyatakan keadaan baterai 110 Vdc Gardu Induk Perawang unit 1 dan unit 2 berada dalam kondisi layak. Berdasarkan hasil perhitungan dapat diketahui bahwa beban unit 1 pada baterai 110 Vdc gardu induk sebesar 770 watt, dan beban unit 2 sebesar 1540 watt.
Defining and testing a wildlife intervention framework for exotic disease control
Authors: Smith Graham C. , Brough Tanis , Podgórski Tomasz , Ježek Milos , Šatrán Petr , Vaclavek Petr , Delahay Richard 
Published: November 2022

Abstract
Outbreaks of disease at the wildlife–livestock interface may require management interventions. Where they involve exotic/non‐endemic pathogens in wildlife, then such plans may need to be rapidly conceived and implemented to prevent further disease spread. However, detailed information on the distribution of infection is likely to be absent, whilst limited resources and tools, and ethical considerations impose constraints on what is possible and proportionate.

We describe four considerations to inform decision‐making on whether to intervene. With reference to two recent examples (bovine tuberculosis in badgers in an otherwise disease‐free area, and African swine fever in wild boar in central Europe), we outline six steps to guide implementation.

In both examples, a Disease Control Area was defined by determining a minimum infected area (MIA) and a buffer zone based on wildlife ecology and the potential for unrecorded spread of infection. The total area was the subject of management intervention, with the level of infection used to inform adaptive management.

The MIA is defined as the minimum area that could contain all infected wildlife, given our current level of information, with a surrounding buffer zone to account for the possibility of further onward spread. In our examples, the zones were defined using a combination of field data and existing knowledge of host spatial organization and movement.

The MIA (plus buffer zone) approach provides a framework for optimizing the targeting of resources in a proportionate response to a disease outbreak. Where infected animals occur outside the MIA, our examples show how wildlife management has been adapted. In principle, this approach is suitable for the delivery of disease outbreak control in wildlife, whether through culling, vaccination or other forms of control.
A KCNC1‐related neurological disorder due to gain of Kv3.1 function
Authors: Clatot Jerome , Ginn Natalie , Costain Gregory , Goldberg Ethan M. 
Published: November 2022

AbstractObjectiveTo further clarify genotype:phenotype correlations associated with variants in KCNC1 encoding the voltage‐gated potassium (K+) channel subunit Kv3.1 and which are an emerging cause of a spectrum of neurological disease including intellectual disability, isolated myoclonus, progressive myoclonus epilepsy, and developmental and epileptic encephalopathy.MethodsWe describe the clinical and genetic characteristics of a series of three patients with de novo heterozygous missense variants in KCNC1 associated with nonspecific developmental delay/intellectual disability and central hypotonia without epilepsy or ataxia. All three variants lead to amino acids alterations with mild predicted differences in physicochemical properties yet are localized to the S6 pore region of the Kv3.1 protein between the selectivity filter and PXP motif important for K+ channel gating. We performed whole‐cell voltage clamp electrophysiological recording of wild‐type versus variants in a heterologous mammalian expression system.ResultsWe demonstrate a prominent leftward (hyperpolarized) shift in the voltage dependence of activation and slowed deactivation of all variants in the clinically defined series.InterpretationElectrophysiological recordings are consistent with a gain of K+ channel function that is predicted to exert a loss of function on the excitability of Kv3‐expressing high frequency‐ firing neurons based on the unique electrophysiological properties of Kv3 channels. These results define a clinical‐genetic syndrome within the spectrum of KCNC1‐related neurological disorders.
1T’ RexMo1−xS2–2H MoS2 Lateral Heterojunction for Enhanced Hydrogen Evolution Reaction Performance
Authors: Nguyen Huong Thi Thanh , Adofo Laud Anim , Yang Sang‐Hyeok , Kim Hyung‐Jin , Choi Soo Ho , Kirubasankar Balakrishnan , Cho Byeong Wook , Ben‐Smith Andrew , Kang Joohoon , Kim Young‐Min , Kim Soo Min , Han Young‐Kyu , Kim Ki Kang 
Published: November 2022

AbstractThe imperfect interfaces between 2D transition metal dichalcogenides (TMDs) are suitable for boosting the hydrogen evolution reaction (HER) during water electrolysis. Here, the improved catalytic activity at the spatial heterojunction between 1T’ RexMo1−xS2 and 2H MoS2 is reported. Atomic‐scale electron microscopy confirms that the heterojunction is constructed by an in‐situ two‐step growth process through chemical vapor deposition. Electrochemical microcell measurements demonstrate that the 1T’ RexMo1−xS2–2H MoS2 lateral heterojunction exhibits the best HER catalytic performance among all TMD catalysts with an overpotential of ≈84 mV at 10 mA cm−2 current density and 58 mV dec−1 Tafel slope. Kelvin probe force microscopy shows ≈40 meV as the work function difference between 2H MoS2 and 1T’ RexMo1−xS2, facilitating the electron transfer from 2H MoS2 to 1T’ RexMo1−xS2 at the heterojunction. First‐principles calculations reveal that Mo‐rich heterojunctions with high structural stability are formed, and the HER performance is improved with the combination of increased density of states near the Fermi level and optimal ΔGH* as low as 0.07 eV. Those synergetic effects with many electrons and active sites with optimal ΔGH* improve HER performance at the heterojunction. These results provide new insights into understanding the role of the heterojunction for HER.
2D Molybdenum Compounds for Electrocatalytic Energy Conversion
Authors: Chen Jianmei , Lin Yanping , Wang Hao , Li Jianmin , Liu Shujuan , Lee Jong‐Min , Zhao Qiang 
Published: November 2022

AbstractThe development of advanced nanomaterials is urgent for electrocatalytic energy conversion applications. Recently, 2D nanomaterial‐derived heterogeneous electrocatalysts have shown great promise for both fundamental research and practical applications owing to their extremely high surface‐to‐volume ratio and tunable geometric and electronic properties. Because of their unique electronic structure and physicochemical properties, molybdenum (Mo)‐based 2D nanomaterials are emerging as one of the most attractive candidates among the nonprecious materials for electrocatalysts. This review provides a comprehensive overview of the recent advances in the synthesis and modulation of 2D Mo compounds for applications in electrocatalytic energy conversion. The categories based on different compositions and corresponding synthetic approaches of 2D Mo compounds are first introduced. Subsequently, various atomic/plane/synergistic engineering strategies, along with catalytic optimization in the electrochemical process that involves the cycles of water, carbon, and nitrogen, are discussed in detail. Finally, the current challenges and future opportunities for the development of 2D Mo‐based electrocatalysts are proposed with the goal of shedding light on these promising 2D nanomaterials for electrocatalytic energy conversion.
High‐Performance Solution‐Processed 2D P‐Type WSe2 Transistors and Circuits through Molecular Doping
Authors: Zou Taoyu , Kim Hyun‐Jun , Kim Soonhyo , Liu Ao , Choi Min‐Yeong , Jung Haksoon , Zhu Huihui , You Insang , Reo Youjin , Lee Woo‐Ju , Kim Yong‐Sung , Kim Cheol‐Joo , Noh Yong‐Young 
Published: November 2022

AbstractSemiconducting ink based on 2D single‐crystal flakes with dangling‐bond‐free surfaces enables the implementation of high‐performance devices on form‐free substrates by cost‐effective and scalable printing processes. However, the lack of solution‐processed p‐type 2D semiconducting inks with high mobility is an obstacle to the development of complementary integrated circuits. Here, a versatile strategy of doping with Br2 is reported to enhance the hole mobility by orders of magnitude for p‐type transistors with 2D layered materials. Br2‐doped WSe2 transistors show a field‐effect hole mobility of more than 27 cm2 V−1 s−1, and a high on/off current ratio of ≈107, and exhibits excellent operational stability during the on‐off switching, cycling, and bias stressing testing. Moreover, complementary inverters composed of patterned p‐type WSe2 and n‐type MoS2 layered films are demonstrated with an ultra‐high gain of 1280 under a driving voltage (VDD) of 7 V. This work unveils the high potential of solution‐processed 2D semiconductors with low‐temperature processability for flexible devices and monolithic circuitry.
Coupling Low‐Tortuosity Carbon Matrix with Single‐Atom Chemistry Enables Dendrite‐Free Potassium‐Metal Anode
Authors: Zhang Dianwei , Ma Xuemei , Wu Lichen , Wen Jie , Li Fuxiang , Zhou Jiang , Rao Apparao M. , Lu Bingan 
Published: November 2022

AbstractPotassium metal is an ideal anode for potassium‐metal batteries due to its low electrode potential and high theoretical capacity. Nevertheless, infinite volume change, uncontrollable K dendrite growth, and unstable solid‐electrolyte interfaces severely restrain its practical viability. Inspired by the vertical channels in natural wood, a spatial control strategy is proposed to address the above challenges using a low‐tortuosity carbon matrix decorated with single‐atom Co catalysts that act as K hosts (denoted as SA‐Co@HC). The homogenously supported Co atoms on the nitrogen‐doped carbon matrix reduce the nucleation energy barrier and promote the deposition kinetics of K. Furthermore, the conductive low‐tortuosity matrix can alter the electric field and allow fast K‐ion transport in the vertical direction. More importantly, the SA‐Co@HC host provides sufficient channel spaces to withstand the tremendous electrode volume change upon cycling. Benefitting from the synergetic effects of the SA‐Co@HC host, the symmetric cell using a SA‐Co@HC/K composite electrode demonstrates a dendrite‐free potassium plating/striping behavior, as well as achieving superb cycling stability of more than 2500 h at 0.5 mA cm−2 in a carbonate‐based electrolyte. The full cell coupled with potassium‐free organic cathodes, the SA‐Co@HC/K composite anode helps deliver excellent cycle and rate performances compared to the bare K anode.
Relationship between rice grain protein content and key phenotypes in rice
Authors: Shi Shijie , Zhao Dan , Xing Junyang , Pan Keqiang , Ma Junjie , Wang Xiaodong , Liu Juan , Cao Cougui , Jiang Yang 
Published: November 2022

AbstractIn our previous study, it was found that protein content was one of the most important factors affecting rice‐eating quality. Because rice cultivars have different phenotypes, they may also have different protein concentrations and eating quality. Based on published phenotypic and measured protein content of 706 rice (Oryza sativa L.) cultivars [453 tropical indica, (O. sativa indica) 61 tropical japonica (O. sativa japonica), 22 temperate indica, and 169 temperate japonica], we studied the potential relationship between grain protein content and the rice phenotype (culm length, panicle length, thousand grain weight, and grain length) through cluster analysis and canonical correlation analysis. The results demonstrated significant differences between japonica and indica rice, as well as between landrace rice and modern rice varieties. The protein content of japonica (average = 8.76%) was higher than that of indica (average = 8.11%). The protein content of all japonica was negatively correlated with culm length (p = 0.007) and panicle length (p = 0.006). The protein content of all indica was positively correlated with grain length (p = 0.0005) and grain length/width ratio (p = 0.043). Canonical correlation analysis showed that panicle length and grain width had the highest canonical loadings and canonical cross‐loadings on the external phenotype and grain characteristics in rice with different protein contents. Panicle length and grain width could better reflect rice phenotype traits under the identical grain protein content type.
Topdress strategies and remote sensing for nitrogen management in processing carrots
Authors: Metiva Michael , Bunting Erin L. , Steinke Kurt , Hayden Zachary D. 
Published: November 2022

AbstractImproved nitrogen (N) fertilizer management strategies are required to optimize yield and quality in processing carrots (Daucus carota L.) while minimizing risks of N loss. A 2‐year field study was conducted in commercial carrot fields near Hesperia and Pentwater, MI, USA, to investigate the effects of N fertilizer rate (29, 67, 135, and 202 kg ha−1 N), topdress N frequency (single vs. three split applications), and timing of split N applications on carrot production and N utilization. In addition, the potential for remote sensing‐based vegetation indices (VIs) to guide in‐season N topdress decisions was evaluated relative to conventional methods including petiole sap nitrate testing. Both carrot root yield and shoot biomass increased with greater N rates but did not plateau. Split‐applied topdress N and timing of topdress applications did not affect yield. However, greater N rates, single front‐loaded applications, and both earlier and later than typical topdress timings exhibited potential to increase N loss depending on the year. While VIs explained at most 66% and 29% of the variation in yield in 2019 and 2020, respectively, the indices consistently explained greater variation compared to petiole sap nitrate (6%), shoot N concentration (8%), and carrot root (10%) and shoot (14%) weights. Hypothetical N topdress decisions made using VI‐based sufficiency indices recommended N 26% less often than petiole sap nitrate, but more research is needed to evaluate reference and threshold selections. Despite labor and technological tradeoffs, remote sensing may increase accuracy, resolution, and scalability of N decision support in processing carrot production.
Behavioral and physiological response to inequity in bonobos (Pan paniscus)
Authors: Verspeek Jonas , Stevens Jeroen M. G. 
Published: November 2022

AbstractInequity aversion (IA), the affective, cognitive, and behavioral response to inequitable outcomes, allows individuals to avoid exploitation and therefore stabilizes cooperation. The presence of IA varies across animal species, which has stimulated research to investigate factors that might explain this variation, and to investigate underlying affective responses. Among great apes, IA is most often studied in chimpanzees. Here, we investigate IA in bonobos, a reputedly tolerant and cooperative species for which few IA studies are available. We describe how bonobos respond to receiving less preferred rewards than a partner in a token exchange task. We show that bonobos respond to receiving less preferred rewards by refusing tokens and rewards, and by leaving the experimental area. Bonobos never refused a trial when receiving preferred rewards, and thus showed no advantageous IA. We also investigate the variability in the disadvantageous IA response on a dyadic level, because the level of IA is expected to vary, depending on characteristics of the dyad. Like in humans and chimpanzees, we show that the tolerance towards inequity was higher in bonobo dyads with more valuable relationships. To study the affective component of IA, we included behavioral and physiological measures of arousal: a displacement behavior (rough self‐scratching) and changes in salivary cortisol levels. Both measures of arousal showed large variability, and while analyses on rough self‐scratching showed no significant effects, salivary cortisol levels seemed to be lower in subjects that received less than their partner, but higher in subjects that received more than their partner, albeit that both were not significantly different from the equity condition. This suggests that although overcompensated bonobos showed no behavioral response, they might be more aroused. Our data support the cooperation hypothesis on an interspecific and intraspecific level. They show inequity aversion in bonobos, a reputedly cooperative species, and suggest that the variability in IA in bonobos can be explained by their socioecology. Most successful cooperative interactions happen between mothers and their sons and among closely bonded females. The limited need to monitor the partners' investment within these dyads can result in a higher tolerance towards inequity. We therefore suggest future studies to consider relevant socioecological characteristics of the species when designing and analyzing IA studies.
Pd0‐Catalyzed Asymmetric Carbonitratation Reaction Featuring an H‐Bonding‐Driven Alkyl−PdII−ONO2 Reductive Elimination
Authors: Qi Linjun , Dong Ming , Qian Jinlong , Yu Shuling , Tong Xiaofeng 
Published: November 2022

AbstractReductive elimination of alkyl−PdII−O is a synthetically useful yet underdeveloped elementary reaction. Here we report that the combination of an H‐bonding donor [PyH][BF4] and AgNO3 additive under toluene/H2O biphasic system can enable such elementary step to form alkyl nitrate. This results in the Pd0‐catalyzed asymmetric carbonitratations of (Z)‐1‐iodo‐1,6‐dienes with (R)‐BINAP as the chiral ligand, affording alkyl nitrates up to 96 % ee. Mechanistic studies disclose that the reaction consists of oxidative addition of Pd0 catalyst to vinyl iodide, anion ligand exchange between I− and NO3−, alkene insertion and SN2‐type alkyl−PdII−ONO2 reductive elimination. Evidences suggest that H‐bonding interaction of PyH⋅⋅⋅ONO2 can facilitate dissociation of O2NO− ligand from the alkyl−PdII−ONO2 species, thus enabling the challenging alkyl−PdII−ONO2 reductive elimination to be feasible.