bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with short and long sleep duration in older adults: Analysis of a national survey in Japan
Authors: Midorikawa Haruhiko , Tachikawa Hirokazu , Aiba Miyuki , Watanabe Taeko , Tamiya Nanako , Arai Tetsuaki 
Published: July 2022

AimThis study aimed to clarify the association between sleep duration and various physical and psychosocial factors among older Japanese adults.MethodsData from 295 367 households were obtained from the 2013 Comprehensive Survey of Living Conditions in Japan, a self‐administered questionnaire survey. We restricted our analyses to 115 205 participants who responded to all the items required for this study. Multinomial logistic regression models examined the association between sleep duration and various factors.ResultsOverall, 26.0% of the participants slept for <6 h, 56.0% slept for 6–8 h, and 18.0% slept for ≥8 h. Poor subjective health and mental health increased the risk of both short (poor subjective health: odds ratio [OR] 1.22, 95% confidence interval [CI] 1.17–1.27; severe mental distress: OR 2.21, 95% CI 2.04–2.40) and long (poor subjective health: OR 1.19, 95% CI 1.13–1.24; severe mental distress: OR 1.25, 95% CI 1.13–1.38) sleep duration. Many subjective symptoms, including chest, respiratory, musculoskeletal and urogenital symptoms, were associated with short sleep duration. However, only memory loss was associated with long sleep duration (OR 1.23, 95% CI 1.16–1.31).ConclusionsWe need to be aware that older people with short sleep duration may have various physical symptoms. Moreover, as physical and mental problems, cognitive decline and unhealthy lifestyles are associated with long sleep duration, we also need to pay attention to the living conditions of those who complain of long sleep duration. The limitations of this study were that the variables were self‐reported and sleep duration was not evaluated objectively. Geriatr Gerontol Int 2022; 22: 660–666.
Pain coping behaviour strategies in people with haemophilia: A systematic literature review
Authors: Foubert Anthe , Roussel Nathalie , Chantrain Valérie‐Anne , Hermans Cédric , Lambert Catherine , Lobet Sébastien , Meeus Mira 
Published: July 2022

AbstractIntroductionDespite the fact that joint bleeds (haemarthrosis) frequently occur in people with haemophilia (PwH) with invalidating arthropathies as result, the clinical pain experience has received only limited attention. A sudden increase in pain intensity can be linked to a bleed, but in most cases, no acute bleed is confirmed. Nevertheless, a patient's perception of an acute bleed as cause of the pain might impact the patients’ behaviour in response to pain. It is therefore essential to gain more insight into pain coping strategies seen in PwH.AimThis systematic review aims to identify the range of pain coping behaviour strategies used among PwH and the factors associated with pain coping behaviour.MethodsThis review was reported according to the Preferred Reporting Items for Systematic reviews and Meta‐analyses guidelines (PRISMA). PubMed and Web of Science were systematically screened for relevant literature using keyword combinations related to adult PwH, pain and pain coping behaviour strategies. Risk of bias was assessed with the modified Newcastle‐Ottowa Scale.ResultsEleven full text articles (nine cross‐sectional and two comparative studies) consisting of 1832 PwH met the inclusion criteria. Due to the heterogeneity of the study samples, quality of evaluation instruments and varying risk of bias, it was difficult to draw conclusions regarding the used pain coping behaviour strategies and associated factors.ConclusionLiterature on pain coping behaviour strategies and associated factors in PwH is still scarce and describes heterogenous results. Validated haemophilia‐specific instruments are warranted to inventory pain coping behaviour in a standardized way.
Declining trends of prevalence ofHelicobacter pyloriinfection and incidence of gastric cancer in Taiwan: An updated cross‐sectional survey and meta‐analysis
Authors: Chen Mei‐Jyh , Bair Ming‐Jong , Chen Po‐Yueh , Lee Ji‐Yuh , Yang Tsung‐Hua , Fang Yu‐Jen , Chen Chieh‐Chang , Chang An‐Ti , Hsiao Wang‐De , Yu Jian‐Jyun , Kuo Chia‐Chi , Chiu Min‐Chin , Lin Kun‐Pei , Tsai Min‐Horn , Hsu Yao‐Chun , Chou Chu‐Kuang , Chen Chi‐Yi , Lin Jaw‐Town , Lee Yi‐Chia , Wu Ming‐Shiang , Liou Jyh‐Ming ,   for the Taiwan Gastrointestinal Disease and Helicobacter Consortium
Published: July 2022

AbstractBackgroundWe aimed to assess the latest prevalence and secular trend ofHelicobacter pyloriinfection and its association with the incidence and mortality of gastric cancer in Taiwan.Materials and MethodsAdults naive toH. pylorieradication received13C‐urea breath test (13C‐UBT),H. pyloristool antigen test, and serology test during 2019–2020 in this prospective screening program. Children and adolescent aged between 7 and 19 years received13C‐UBT forH. pyloriscreening. We also conducted a systematic review and meta‐analysis to assess the secular trend of prevalence ofH. pylorifrom 1990 to 2020 in Taiwan. The secular trends of age‐standardized incidence and mortality of gastric cancer were obtained from the Taiwan Cancer Registry.ResultsA total of 1494 participants were enrolled, including 294 children or adolescents and 1200 adults. The overall prevalence of activeH. pyloriinfection by13C‐UBT was 26.6% (397/1494), which was 30.8% in adults and 9.5% in adolescents/children. The age‐standardized prevalence of activeH. pyloriinfection was 32.3% in adults after adjustment of the population structure in Taiwan. Of the 29 studies including 38,597 subjects eligible for the meta‐analysis, the pooled prevalence ofH. pyloriinfection decreased from 63.8% (95% CI: 55.9%–71%) in 1990–2000 to 28.2% (95% CI:21.8%–35.6%) in 2016–2020. The age‐standardized incidence and mortality of gastric cancer have also declined from 15.2 to 10.75 per 100,000, respectively, in 1999 to 9.29 and 5.4 per 100,000, respectively, in 2019.ConclusionsThe prevalence ofH. pyloriinfection has declined in Taiwan, which correlates with the declining trends of age‐standardized incidence and mortality of gastric cancer in Taiwan.
Geometric compromise programming: application in portfolio selection
Authors: Salas‐Molina Francisco , Pla‐Santamaria David , Vercher‐Ferrandiz Maria Luisa , Garcia‐Bernabeu Ana 
Published: July 2022

AbstractCompromise programming (CP) aims to find solutions by minimising distances to an ideal point with maximum achievement which is usually infeasible. A common assumption in CP is that it is highly unlikely that the optimum decision will lie out of the bounds of the compromise set given by metrics and of the Minkowski distance function. This assumption excludes the use of multiplicative functions as a measure of achievement. We propose geometric CP (GCP) to provide alternative solutions based on multiplicative functions to overcome this limitation. This methodology is an extension of CP that allows to incorporate the principle of limited compensability. An additional interesting feature of GCP is that, under reasonable assumptions, characterises extreme seekers' behaviour with non‐concave utility functions (expressing no preference for any of the extremes). We discuss the practical implications of our approach and present three numerical illustrations in the context portfolio selection.
Ontogenetic changes in the tooth morphology of bull sharks (Carcharhinus leucas)
Authors: Goodman Kyle , Niella Yuri , Bliss‐Henaghan Taylor , Harcourt Robert , Smoothey Amy F. , Peddemors Victor M. 
Published: July 2022

AbstractTeeth are an integral component of feeding ecology, with a clear link between tooth morphology and diet, as without suitable dentition prey cannot be captured nor broken down for consumption. Bull sharks, Carcharhinus leucas, undergo an ontogenetic niche shift from freshwater to marine habitats, which raises the question: does tooth morphology change with ontogeny? Tooth shape, surface area and thickness were measured using both morphometrics and elliptic Fourier analysis to determine if morphology varied with position in the jaw and if there was an ontogenetic change concordant with this niche shift. Significant ontogenetic differences in tooth morphology as a function of position in the jaw and shark total length were found, with upper and lower jaws of bull sharks presenting two different tooth morphologies. Tooth shape and thickness fell into two groupings, anterior and posterior, in both the upper and lower jaws. Tooth surface area, however, indicated three groupings, mesial, intermediate and distal, in both the upper and lower jaws. While tooth morphology changed significantly with size, showing an inflection at sharks of 135 cm total length, each morphological aspect retained the same tooth groupings throughout. These ontogenetic differences in tooth morphologies reflect tooth strength, prey handling and heterodonty.
SICKLE represses photomorphogenic development of Arabidopsis seedlings via HY5‐ and PIF4‐mediated signaling
Authors: Li Tao , Li Haojie , Lian Hongmei , Song Pengyu , Wang Yulong , Duan Jie , Song Zhaoqing , Cao Yan , Xu Dongqing , Li Jigang , Zhang Huiyong 
Published: July 2022

AbstractArabidopsis CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) and PHYTOCHROME INTERACTING FACTORs (PIFs) are negative regulators, and ELONGATED HYPOCOTYL5 (HY5) is a positive regulator of seedling photomorphogenic development. Here, we report that SICKLE (SIC), a proline rich protein, acts as a novel negative regulator of photomorphogenesis. HY5 directly binds the SIC promoter and activates SIC expression in response to light. In turn, SIC physically interacts with HY5 and interferes with its transcriptional regulation of downstream target genes. Moreover, SIC interacts with PIF4 and promotes PIF4‐activated transcription of itself. Interestingly, SIC is targeted by COP1 for 26S proteasome‐mediated degradation in the dark. Collectively, our data demonstrate that light‐induced SIC functions as a brake to prevent exaggerated light response via mediating HY5 and PIF4 signaling, and its degradation by COP1 in the dark avoid too strong inhibition on photomorphogenesis at the beginning of light exposure.
When law and data collide: the methodological challenge of conducting mixed methods research in law
Authors: BLACKHAM ALYSIA 
Published: July 2022

AbstractA mixed methods research methodology – one that integrates both qualitative and quantitative research methods – theoretically offers substantial advantages for empirical legal scholarship. I argue that mixed methods represent both a challenge to socio‐legal scholarship and an invitation to re‐evaluate our approach to socio‐legal research; indeed, mixed methods are well aligned with the inclusive and eclectic nature of the field. At present, though, these opportunities appear underutilized. This article considers how socio‐legal scholarship might advance mixed methods methodology through a renewed focus on qualitative methods, improved dialogue between methods, and an emphasis on the practical ‘messiness’ of quantitative data. Drawing on an empirical mixed methods study of the enforcement of age discrimination law, I illustrate how legal data pose their own challenges to the methodologies of quantitatively‐oriented mixed methods researchers.
Correlated evolution of craniodental morphology and feeding ecology in carnivorans: a comparative analysis of jaw lever arms at tooth positions
Authors: Harano T. , Asahara M. 
Published: July 2022

AbstractSpecies in the mammalian order Carnivora have extremely diverse diets. The association between diet and craniodental morphology in carnivorans has been the subject of a number of studies. The distance from the jaw joint to the tooth positions may contribute to the ability to acquire and process food because it corresponds to the outlever arm when the jaw functions as a lever to generate a bite force. A shorter outlever arm relative to the inlever arm of the masticatory muscle generates a higher bite force. This study measured the distances from the jaw joint to different points of the teeth as the outlever lengths in the crania of terrestrial Carnivora species to show that outlever lengths corrected for phylogeny and a measure of the inlever length differ according to dietary habits among carnivorans. The distance from the jaw joint to the last molar was shortest in folivores, followed by aquatic prey specialists, suggesting that consumption of tough plant materials and, to some extent, aquatic prey with hard exoskeletons has favoured the evolution of a shorter outlever to allow stronger bites with enlarged molars. In contrast, among Canidae species, a shorter outlever to canines was associated with feeding on large prey, but this association was not found across carnivorans, suggesting that the correlated evolution of a shorter outlever at the canines and specialization for feeding on large prey depends on foraging and hunting behaviours. Combined, these findings provide some evidence that distances from the jaw joint to different points of the teeth are adapted to different feeding ecologies in carnivorans.
DNA methylation differences during development distinguish sympatric morphs of Arctic charr (Salvelinus alpinus)
Authors: Matlosz Sébastien , Sigurgeirsson Benjamín , Franzdóttir Sigrídur Rut , Pálsson Arnar , Jónsson Zophonías O. 
Published: July 2022

AbstractChanges in DNA methylation in specific coding or non‐coding regions can influence development and potentially divergence in traits within species and groups. While the impact of epigenetic variation on developmental pathways associated with evolutionary divergence is the focus of intense investigation, few studies have looked at recently diverged systems. Phenotypic diversity between closely related populations of Arctic charr (Salvelinus alpinus), which diverged within the last 10,000 years, offers an interesting ecological model to address such effects. Using bisulphite sequencing, we studied general DNA methylation patterns during development in the four sympatric morphs of Arctic charr from Lake Thingvallavatn. The data revealed strong differences between developmental timepoints and between morphs (mainly along the benthic–limnetic axis), both at single CpG sites and in 1000 bp‐regions. Genes located close to differentially methylated CpG sites were involved in nucleosome assembly, regulation of osteoclast differentiation, and cell‐matrix adhesion. Differentially methylated regions were enriched in tRNA and rRNA sequences, and half of them were located close to transcription start sites. The expression of 14 genes showing methylation differences over time or between morphs was further investigated by qPCR and nine of these were found to be differentially expressed between morphs. Four genes (ARHGEF37‐like, H3‐like, MPP3 and MEGF9) showed a correlation between methylation and expression. Lastly, histone gene clusters displayed interesting methylation differences between timepoints and morphs, as well as intragenic methylation variation. The results presented here provide a motivation for further studies on the contribution of epigenetic traits, such as DNA methylation, to phenotypic diversity and developmental mechanisms.
Barley guanine nucleotide exchange factor HvGEF14 is an activator of the susceptibility factor HvRACB and supports host cell entry by Blumeria graminis f. sp. hordei
Authors: Trutzenberg Adriana , Engelhardt Stefan , Weiß Lukas , Hückelhoven Ralph 
Published: July 2022

AbstractIn barley (Hordeum vulgare), signalling rat sarcoma homolog (RHO) of plants guanosine triphosphate hydrolases (ROP GTPases) support the penetration success of Blumeria graminis f. sp. hordei but little is known about ROP activation. Guanine nucleotide exchange factors (GEFs) facilitate the exchange of ROP‐bound GDP for GTP and thereby turn ROPs into a signalling‐activated ROP‐GTP state. Plants possess a unique class of GEFs harbouring a plant‐specific ROP nucleotide exchanger domain (PRONE). Here, we performed phylogenetic analyses and annotated barley PRONE‐GEFs. The leaf epidermal‐expressed PRONE‐GEF HvGEF14 undergoes a transcriptional down‐regulation on inoculation with B. graminis f. sp. hordei and directly interacts with the ROP GTPase and susceptibility factor HvRACB in yeast and in planta. Overexpression of activated HvRACB or of HvGEF14 led to the recruitment of ROP downstream interactor HvRIC171 to the cell periphery. HvGEF14 further supported direct interaction of HvRACB with a HvRACB‐GTP‐binding CRIB (Cdc42/Rac Interactive Binding motif) domain‐containing HvRIC171 truncation. Finally, the overexpression of HvGEF14 caused enhanced susceptibility to fungal entry, while HvGEF14 RNAi provoked a trend to more penetration resistance. HvGEF14 might therefore play a role in the activation of HvRACB in barley epidermal cells during fungal penetration.
Lemierre's syndrome from odontogenic infection causing thrombophlebitis within the external and internal jugular veins—A case report
Authors: Winterburn Julia , Cottam Samantha 
Published: July 2022

AbstractLemierre's syndrome is a rare but potentially life‐threatening condition primarily caused by anaerobic bacteria within in the oropharyngeal region. It largely affects otherwise healthy individuals, following an oropharyngeal infection, leading to sepsis and thrombophlebitis of the internal jugular vein. Management can involve a prolonged course of antibiotics, exclusion of the source of infection, surgical drainage and anticoagulant therapy. This case report describes a rare presentation of this condition causing thrombosis within the external jugular vein and significant sepsis in an otherwise healthy 41‐year‐old male. He presented with severe neck pain and trismus, and the source of the infection was deemed to be an infected mandibular molar. The patient has undergone a full recovery following intravenous antibiotics, anticoagulation and later extraction of the offending tooth. Our aim is to educate clinicians on the importance of this uncommon but clinically significant condition, that is increasing in prevalence and can lead to significant morbidity.
Surgical management of peri‐implantitis: A narrative review
Authors: Thomas Jack , Claydon Nicholas 
Published: July 2022

AbstractBackground and aimPeri‐implantitis is a biological complication characterised by inflammation and progressive bone loss around a dental implant. The definitions of peri‐implantitis show inconsistency, making diagnosis and treatment regimen incomparable. The 2017 World Workshop on the Classification of Periodontal and Peri‐implant diseases rationalised the definition of peri‐implantitis. This narrative review aims to provide an overview of the surgical management of peri‐implantitis and critically evaluate current evidence published after the 2017 World Workshop.MethodAn electronic literature search of MEDLINE, EMBASE and The Cochrane Library was performed, limited to prospective cohort studies and randomised controlled trials. Outcome measures were: bleeding on probing, suppuration on probing, pocket probing depth and radiographic marginal bone level.ResultsNine randomised controlled trials met the inclusion criteria. None of the studies used the 2017 World Workshop definition for peri‐implantitis. Seven studies were regenerative in nature (four xenografts, two alloplasts and one enamel matrix derivative). Two studies were non‐regenerative. Aggregation of outcome data was not possible due to significant heterogeneities for treatment protocols and volunteer inclusion criteria. All interventions led to a reduction in bleeding on probing and pocket probing depths. Gain in radiographic bone height was greater for regenerative studies.ConclusionSurgical interventions for peri‐implantitis appear effective at reducing clinical signs of inflammation in the short term. There is no reliable evidence to determine which methods are most effective. Universal adoption of the 2017 World Workshop definition of peri‐implantitis by future studies is a prerequisite for the development of standardised evidence‐based protocols for the treatment of peri‐implantitis.
Should we stay aware of monkeypox maxillofacial lesions?
Authors: Ribeiro Bruna Campos , Costa Samuel Macedo 
Published: July 2022

AbstractMonkeypox is an endemic infectious disease commonly observed only in Central Africa; however in the last month, WHO considered it an international outbreak, with several cases described in a short span. Oral surgeons are exposed to patients at risk for monkeypox and some of the most prevalent lesions could be observed first in the maxillofacial region. The knowledge of the common signs and symptoms of the monkeypox and associated diseases is fundamental to the report and referral to infectious diseases centers for definitive treatment and public health control. This letter to the editor summarizes the associated diseases and common maxillofacial lesions observed in monkeypox infection.
Comparison of two point‐of‐care measurements of hemoglobin against standard laboratory values during pediatric liver transplantation: A retrospective review
Authors: Morris Bethany L. , Hajduk John , Cheon Eric C. , Ballard Heather A. , Burjek Nicholas E. 
Published: July 2022

AbstractBackgroundPoint‐of‐care hemoglobin testing devices play an important role in intraoperative anesthetic management where significant hemorrhage is anticipated; however, the reliability of these devices has not been examined in the context of pediatric liver transplantation. In this retrospective observational study, we aimed to determine whether 95% of results from two point‐of‐care hemoglobinometers, the HemoCue and iSTAT, would fall within a difference of ±1 g/dl, our a priori‐defined clinically acceptable level of agreement, of the hemoglobin measures on a core laboratory complete blood count.MethodsWe retrospectively collected data from 70 patients presenting for a liver transplant at a single center, tertiary care pediatric hospital over a 3.5‐year period. We analyzed 92 contemporaneous pairs of hemoglobin values from the HemoCue and complete blood count, and 252 pairs of hemoglobin values from the iSTAT and complete blood count. Agreement between the point‐of‐care devices and complete blood count was assessed using Bland–Altman analysis, which was the primary outcome. Secondary analyses included an error grid analysis and Cohen's kappa statistic.ResultsBoth point‐of‐care devices underestimated complete blood count hemoglobin values and neither device satisfied our a priori‐defined clinically acceptable level of agreement that 95% of values would fall within ±1 g/dl of the complete blood count measurement. The mean difference [limits of agreement] of the HemoCue was 0.4 g/dl (p < .001) [−0.9 to 1.6 g/dl] and of the iSTAT was 0.6 g/dl (p < .001) [−1.4 to 2.6 g/dl]. Secondary error grid analysis revealed that neither device performed well enough to replace a complete blood count at critical thresholds of hemoglobin values.ConclusionsWhile the HemoCue and iSTAT contribute information in a timely manner during dynamic intraoperative situations, there is significant imprecision compared to the gold standard complete blood count. If clinical stability allows, the results of these point‐of‐care hemoglobinometers should be confirmed with a complete blood count, rather than being used as the sole factor in determining transfusion needs during pediatric liver transplantation.