bluuebunny/crossref_metadata_2025_split huggingface dataset:
A moment in time: multidisciplinary evidence of an isolated Neanderthal occupation in Abric del Pastor (Alcoi, Iberian peninsula)
Authors: Sossa-Ríos Santiago , Mayor Alejandro , Hernández Cristo M. , Bencomo Mariel , Pérez Leopoldo , Galván Bertila , Mallol Carolina , Vaquero Manuel 
Published: July 2022

Abstract
Testing Neanderthal behavioural hypotheses requires a spatial-temporal resolution to the level of a single human occupation episode. Yet, most of the behavioural data on Neanderthals has been obtained from coarsely dated, time-averaged contexts affected by the archaeological palimpsest effect and a diversity of postdepositional processes. This implies that time-resolved Neanderthal behaviour remains largely unknown. In this study, we performed archaeostratigraphic analysis on stratigraphic units ive, ivf, ivg, va, vb and vc from Abric del Pastor (Alcoi, Iberian peninsula). Further, we isolated the archaeological remains associated with the resulting archaeostratigraphic unit and applied raw material, technological, use-wear, archaeozoological and spatial analyses. Our results show a low-density accumulation of remains from flintknapping, flint tool-use and animal processing around a hearth. These data provide a time-resolved human dimension to previous high-resolution environmental and pyrotechnological data on the same hearth, representing the first comprehensive characterisation of a single Neanderthal occupation episode. Our integrated, multidisciplinary method also contributes to advance our understanding of archaeological record formation processes.
CBR and Durability Characteristics of Cementitious High- Plasticity Graded Gravel Soils by Curing Methods
Authors:   1. Chandra Sekar Ganja,   2. Prof.Veera Venkata Satyanarayana Pasalapudi
Published: July 2022

Abstract
The suitability of cement-treated high plasticity graded gravel soils for road base and sub-base layers is discussed in this paper. Selected high plasticity gravel soils are classified into several levels based on their size, i.e., G50-50& G50-50*, G35-65& G35-65*, G25-75& G25-75*, respectively, to explore the effect of gradation on their strength and durability. The CBR test determines the improved CBR percentage for each gradation when the cement admixture is increased using the partial curing method (3 days wet gunny bags and 4 days water curing). To measure the durability of the mixture, wet and dry tests were performed on all high plasticity cementitious graded gravel mixtures. According to the test results, the gravel level, plasticity, and curing process directly affect the mixture's strength and durability. According to the test results, high plasticity soils, gradations G50-50& G50-50*, have CBR percent values of 112 to 128& 102 to 116, respectively, with 7-8 percent cement addition by partial curing method, which is more than enough for the base and sub-base layers of road construction as per MoRTH specifications. Scanning electronic microscope (SEM) and Energy Dispersive X-ray Spectroscopy (EDS) analysis yielded a large amount of ettringite and a higher Si / Ca ratio for high plasticity graded gravel mixes than the cement-treated high plasticity graded gravel mixes.
Bos Taurus (A-2) Urine Assisted Bioactive Cobalt Oxide Anchored ZnO: A Novel Nanoscale approach
Authors: Karvekar Omkar S. , Vadanagekar Apurva S. , Sarvalkar Prashant , Jadhav Sarita , Singhan Richa , Suryawanshi Suresh , Jadhav Jyoti , Sharma Kiran Kumar , Prasad Neeraj 
Published: July 2022

Abstract
Biomimetic nanotechnology is a fast-growing technology with far-reaching implications in a variety of therapeutic applications. The goal of this research is to develop green, environmentally friendly, and cost-effective strategies for producing cobalt oxide (Co3O4) nanoparticles from Bos Taurus Indicus (A-2) urine and zinc oxide nanorods from the hydrothermal process. A solid-state reaction process is used to make nanocomposite materials. The synthesized nanomaterials and composites were characterized using advanced characterization techniques such as XRD, FE-SEM with EDS, DLS, Zeta potential, FT-IR, Raman spectroscopic analysis, and TGA with DSC analysis. The anti-bacterial, Anti-oxidant and anti-inflammatory effects of the synthesized nanomaterials and composites were investigated. This implies that they might be beneficial in medicine and drug administration.
Efficacy and safety linear ablation for persistent atrial fibrillation: PVI plus linear ablation of mitral isthmus and posterior box isolation
Authors: li xi , Liu Tao , Cui Bo , Zhang Jinlin , Chen Yanhong , Wu Gang 
Published: July 2022

Abstract
For patients with persistent atrial fibrillation(PAF), whether linear ablation should be performed remains controversial, and the efficacy and safety for ablation index༈AI༉guided high energy linear ablation of mitral isthmus (MI) and left atrial (LA) posterior wall is still unclear. The aims of the this study were to assess the feasibility and clinical success rate of pulmonary veins isolation (PVI) combined with AI-guided high‐power linear ablation of LA roof and posterior inferior༈LA posterior wall isolation༉and MI for PAF patients. 200 consecutive PAF patients were enrolled. PVI combined with linear ablation of left atrial posterior wall isolation༈LAPWI༉ and MI were performed in all patients using AI-guided high-power pattern (ablation power was set to 45 W, targeting AI 400–500). The confirmation of the MI linear conduction block and LAPWI were performed after ablation. The procedure-related complication rate was 2.0%. During an average follow-up period of 24 months, freedom from atrial fibrillation or atrial tachycardia was achieved in 87.5% of the patients. Our ablation strategy of linear ablation was feasible and safe for PAF patients.
Host Species and Habitat Shape Fish- associated Bacterial Communities: Phylosymbiosis between Fish and their Microbiome
Authors: Sadeghi Javad , Chaganti Subba Rao , Johnson Timothy B. , Heath Daniel D. 
Published: July 2022

Abstract
BackgroundWhile many studies have reported that the structure of the gut and skin microbiome is driven by both species-specific and habitat-specific factors, the relative importance of host-specific versus environmental factors in wild vertebrates remains poorly understood. The aim of this study was to determine the diversity and composition of fish skin, gut, and surrounding water bacterial communities (BCs) and assess the extent to which host habitat and phylogeny predict BC similarity. Skin swabs and gut samples from 334 fish belonging to 17 species were sampled in three Laurentian Great Lakes (LGLs) habitats (Detroit River, Lake Erie, Lake Ontario). We also collected and filtered water samples at the time of fish collection. We analyzed BC composition using 16S metabarcoding and tested for community variation. ResultsWe found that the water BC was distinct from the fish microbiome BCs, although the skin BC more closely resembled the water BC. We also found that environmental (sample location), habitat, fish diet and host species factors shape and promote divergence or convergence of the fish BCs. Since host species significantly affected both gut and skin BC (separately from host species effects), we tested for phylosymbiosis using pairwise host species phylogenetic distance versus BC dissimilarity. We found significant phylogenetic effects on BC dissimilarity, consistent with phylosymbiosis for both the fish skin and gut BCs, perhaps reflecting the longstanding co-evolutionary relationship between the host species and their microbiomes. ConclusionsAnalyzing the gut content and skin mucus BCs across diverse fish species in complex natural ecosystems such as the LGLs provides insights into the potential for habitat and species-specific effects on the microbiome, and ultimately the health, of the host.
Multi-state Data Storage in a Two-dimensional Stripy Antiferromagnet Implemented by Magnetoelectric Effect
Authors: Gu Pingfan , Wang Cong , Su Dan , Dong Zehao , Wang Qiuyuan , Han Zheng , Watanabe Kenji , Taniguchi Takashi , Ji Wei , Sun Young , Ye Yu 
Published: July 2022

Abstract
A promising approach to the next generation of low-power, functional, and energy-efficient electronics relies on novel materials with coupled magnetic and electric degrees of freedom. In particular, stripy antiferromagnets often exhibit broken crystal and magnetic symmetries, which may bring about the magnetoelectric (ME) effect and enable the manipulation of intriguing properties and functionalities by electrical means. The demand for expanding the boundaries of data storage and processing technologies has led to the development of spintronics toward two-dimensional (2D) platforms. This work reports the ME effect in the 2D stripy antiferromagnetic insulator CrOCl down to a single layer. By measuring the tunneling resistance of CrOCl on the parameter space of temperature, magnetic field, and applied voltage, we verified the ME coupling down to the 2D limit and unraveled its mechanism. Utilizing the multi-stable states and ME coupling at magnetic phase transitions, we realize multi-state data storage in the tunneling devices. Our work not only advances the fundamental understanding of spin-charge coupling, but also demonstrates the great potential of 2D antiferromagnetic materials to deliver devices and circuits beyond the traditional binary operations.
The Effects of HCL Concentration and Ultrasound- Assisted on the Fabrication of Cellulose Nanocrystal Derived from Sugarcane Bagasse
Authors: Fathana Haya , Rahmi Rahmi , Lubis Surya , Adlim Muhammad , Muktaridha Omar , Iqhramullah Muhammad 
Published: July 2022

Abstract
The fabrication of Cellulose nanocrystals (CNCs) from sugarcane baggasse (SCB) using acid hydrolysis at various concentrations (5, 10, 20, 25, and 30%) and ultrasound-assisted is presented in this paper. The fabricated CNCs were also thoroughly analyzed using Fourier Transform Infrared Spectroscopy (FTIR) to investigate surface functional groups and X-ray diffraction (XRD) to investigate structural properties. The particle size distribution following the ultrasonication procedure was also measured using a particle size analyzer (PSA) in this investigation. The content of hemicellulose and lignin will decrease as the concentration of HCl in the hydrolysis process increase. On the other hand, the α-cellulose content was increasing. The best concentration of HCl is 20%. FTIR data shows that a sharper increase in intensity can be seen in the HCl 10% and HCl 20% samples. XRD data revealed that the crystal size was 2.732 nm and the index crystallinity of CNCs was 63,57%, while PSA analysis revealed that the average particle size was 125.1 nm.
ADAMTS5 modulates breast cancer development as a diagnostic biomarker and potential tumor suppressor, regulating by BAIAP2-AS1, VTI1B, CRNDE, and hsa-miR-135b-3p: integrated systems biology and experimental approach
Authors: Tavousi Najmeh , Taqizadeh Qazal , Nasiriyan Elnaz , Tabaeian Parastoo , Rezaei Mohammad , Azadeh Mansoureh 
Published: July 2022

Abstract
Background: A disintegrin and metalloproteinases (ADAMs) are a novel gene family of proteins that share the metalloproteinase domain with matrix metalloproteinases and have sequence similarities to the reprolysin family of snake venomases (MMPs). They are divided into two classes based on their structural similarities: membrane-anchored ADAM and ADAM with thrombospondin motifs (ADAMTS). These molecules have a role in a number of biological processes, including membrane protein shedding, proteolysis, cell adhesion, cell fusion, and cell migration. Method: In this study, the RNA interaction analysis (miRWalk, lncRRisearch, ENCORI, and lncBase3) and protein interaction analysis (STRING) was performed. Survival, expression, and correlation analyses was performed by ENCORI and GEPIA2. Expression analysis also performed by microarray analysis. GSEA analysis was performed to find top up and down-regulated genes and relevant signaling pathway. Gene ontology analysis was performed by g: Profiler and clusterprofiler. Pathway enrichment was performed by GSEA analysis.ResultsADAMTS5 has a significant low-expression, based on ENCORI (Fold Change: 0.12, FDR < 0.0001), microarray analysis (logFC: -3.791881, adj. P. Val < 0.0001), and qRT-PCR experiment (logFC: -1.975, FC: 0.025, p. value < 0.0001, patients under 40). ADAMTS5 is a potential diagnostic biomarker of BC, based on ROC curve (AUC: 0.75, p. value: 0.0007). mRNA VTI1B, lncRNAs CRNDE and BAIAP2-AS1, and hsa-miR-135a-3b have interaction with ADAMTS5. VTI1B has a significant low-expression (FC: 0.65, FDR: 0.0001). BAIAP2-AS1 is significantly up-regulated (FC: 1.37, FDR: 0.0001). CRNDE is significantly up-regulated (FC: 1.30, FDR: 0.0001). BAIAP2 (log-Rank p: 0.0017, Hazard Ratio: 0.59) and CRNDE (log-Rank p: 0.34, Hazard Ratio: 1.17) are the two potential BC survival predictor.ConclusionIn this study, we performed a differential expression analysis on the expression level of ADAMTS5, VTI1B, and BAIAP2-AS1 in the BC patients for the first time. ADAMTS5 and its correlated oncogene and tumor suppressor RNAs and proteins are the hub therapeutic target of BC. DEGs of the GSE42568 dataset are involve in PPAR and cell cycle checkpoint signaling pathways and during the regulation of mentioned pathway, regulate the BC development. Targeting the expression and interaction of mentioned RNAs can be helpful for the diagnosis, prognosis, and treatment of BC.
Relationship between perfusion index and central temperature before and after induction of anesthesia in laparoscopic gastrointestinal surgery: a prospective cohort study
Authors: Hara Kentaro , Kaneko Shohei , Ishioka Taichi , Tobinaga Shohei , Urabe Shigehiko , Nakao Akiha , Hamada Kozue , Nagaoka Kyoko , Taniguchi Miwa , Yamaguchi Michiko , Takeshita Hiroaki , Tanaka Junichi , Kuroda Hiromi , Matsuura Emi , Ishimatsu Yuji , Honda Sumihisa , Sawai Terumitsu 
Published: July 2022

Abstract
Background
The cut-off value of perfusion index (PI) before the induction of anesthesia and the ratio of PI variation after the induction of anesthesia, which is effective in preventing redistribution hypothermia, have not been clarified to date. This study aimed to clarify the relationship between PI and central temperature during the induction of anesthesia and PI potential for individualized and effective control of redistribution hypothermia.
Methods
This prospective observational single-center study analyzed 100 cases of general anesthesia gastrointestinal surgery in the operating room from August 2021 to February 2022. PI was measured as peripheral perfusion, and the relationship between central and peripheral temperature values was investigated. Receiver operating characteristic curve analysis was performed to identify the baseline PI before anesthesia that predicts the decrease in central temperature 30 min after anesthesia induction and the rate of change in PI that predicts the decrease in central temperature 60 min after anesthesia induction.
Results
PI had a significant association with peripheral (p < 0.01) and central temperatures (p < 0.01). In cases where the central temperature decreased by ≥ 0.6℃ after 30 min, the area under the curve (AUC) was 0.744, Youden’s index was 0.456, and cut-off value of baseline PI was 2.30. In cases in which the central temperature decreased by ≥ 0.6℃ after 60 min, the AUC was 0.857, Youden’s index was 0.693, and cut-off value of the ratio of variation in PI after 30 min of anesthesia induction was 1.58.
Conclusions
Our results indicate that if baseline PI is 2.30 or lower and the PI 30 min after induction of anesthesia is at least 1.58 times the PI ratio of variation, there is a high probability of the central temperature decreasing by at least 0.6℃ within 30 min after each timepoint.
Clinical and quality of life outcomes following reduction mammoplasty for symptomatic macromastia among Sri Lankan women: a prospective cohort study
Authors: Wijesinghe Kanchana , Jayarajah Umesh , Mallawaarachchi Malllawaarchchige Gayan Ranjan , De Silva Sumali Hirunika , De Silva Thathya Thamarasie Wardana , Krishnamoorthy Ananthmoorthy , Rubeka Dissanayaka Mudiyanselage Shihanie , De Silva Ajith 
Published: July 2022

Abstract
Background
The impact of macromastia is unfortunately underestimated among the developing South Asian countries. The resulting distress can make it challenging for patients to be physically active and affect their quality of life (QoL). Reduction mammoplasty is a standard treatment option for people suffering from symptomatic macromastia. Therefore we aimed to evaluate the efficacy of reduction mammoplasty in alleviating symptoms of macromastia and its impact on quality of life among Sri Lanka females.
Methods
A prospective study was conducted among 48 patients who underwent reduction mammoplasty in a surgical unit at National Hospital of Sri Lanka from 2016 January to 2021 January. SF-36 questionnaire which is validated in Sri Lanka was used to assess the quality of life. To assess pain related to macromastia, a visual analogue scale was used from 0 to 10 according to the level of intensity. The outcomes were assessed one week prior to surgery and at 2 weeks and 6 months after surgery.
Results
Median age was 43 years and median BMI was 26.8 kg/m2. The commonest presentation was breast and musculoskeletal pain (100%), shoulder grooving (81.3%) and sub-mammary intertrigo (37.5%). The average duration of symptoms was 2 years. All patients initially being reluctant to seek medical advice. Only 10.4 % of patients were aware of availability of treatment. Wise pattern reduction mammoplasty was performed in 79.2%. The commonest complications were wound dehiscence (4/48) followed by surgical site infection (2/48) and nipple necrosis (1/48). There was a significant improvement in satisfaction with breast aesthetics and reduction in pain following surgery. There was also an improvement in all 8 domains of the quality of life following surgery in comparison to the pre-operative scores especially in general health, pain and physical functions.
Conclusion
Our study clearly demonstrated that reduction mammoplasty caused a significant improvement in the overall quality of life and psychological wellbeing with significant reduction in pain for patients suffering from macromastia. Creating more awareness among the public to encourage women to openly discuss about breast related symptoms and to overcome socio cultural taboos and barriers is a timely necessity.
An Assessment of the performance of the National Health Research System in Mauritius to accelerate progress towards Universal Health Coverage
Authors: Musango Laurent , Nundoochan Ajoy , Kirigia Joses Muthuri , Ramful Yogendranath 
Published: July 2022

Abstract
Background: The goal of universal health coverage (UHC) is that every individual has access to quality health services without running the consequences of financial hardship. The World health report 2013 "Research for universal health coverage" states a performant National Health Research Systems (NHRS) can contribute by providing solutions to challenges encountered in advancing towards UHC by 2030. The WHO Regional Committee for Africa adopted a resolution in 2015 urging member states to strengthen their NHRS to facilitate production and utilization of evidence in policy development, planning, product development, innovation, and decision-making. This study aimed to calculate NHRS barometer score for Mauritius in 2020, identify the gaps in NHRS performance, and recommend interventions for boosting the Mauritius NHRS in the pursuit of UHC.Methods: The study used a cross-sectional survey design. A semi-structured NHRS questionnaire was administered and complemented with a review of documents archived in pertinent Mauritius Government Ministries, universities, research-oriented departments and non-governmental organizations websites. The African NHRS barometer developed in 2016 for countries to monitor the RC resolution implementation was applied. The barometer consists of four NHRS functions (leadership and governance, developing and sustaining resources, producing and utilizing research, financing research for health [R4H]), and 17 sub-functions.Results: In 2020, Mauritius had an overall average NHRS barometer score of 60.84%, a 38.27% improvement compared to a score of 44.0% in 2018. The four NHRS functions average indices were 50.0% for leadership and governance, 77.0% for developing and sustaining resources, 52.0% for producing and utilizing R4H, and 58.2% for financing R4H. The overall NHRS barometer score improvements are attributed to the underlying performance growth of 50.0% in leadership and governance, 29.0% in developing and sustaining resources, and 16.4% in financing R4H. Conclusion: The performance of NHRS could be improved further through the development of a national R4H policy, strategic plan, prioritized agenda, and national multi-stakeholder health research management forum. Furthermore, increased funding for the NHRS may nurture the human resources for health research capacities, hence the number of pertinent publications and health innovations.
A case of idiopathic unilateral calcification of the optic nerve, chiasm and optic tract.
Authors: Piashko Yauhen A. , Zhurauliou Vladimir , Kramarenko Aleksandra N. , Bayramova Ayya 
Published: July 2022

Abstract
Purpose
We present a rare case of unilateral calcification of the optic nerve, half of the chiasm, and optic tract.
Methods
Observational case report.
Results
The patient has no traumatic history or metabolic disorders which we can associate with this disease. Complete blindness of the left eye noted from the age of 3. We detected nerve calcification at 36 after removing the tuberculum sellae meningioma.
Conclusion
Our clinical case isn’t a consequence of a meningioma since blindness developed. At this age, the appearance of meningiomas is extremely unlikely, which is confirmed by absence of sings of a tumor on neuroimaging from 2014.
Full Surface Defect Detection of Spherical Fruit Based on Hyperspectral Online Sorting Technology
Authors: SHANG Mengmeng , XUE Long , ZHANG Yifan , LIU Muhua , LI Jing 
Published: July 2022

Abstract
The whole surface hyperspectral image acquisition of spherical fruit is particularly important for the detection and quality classification of fruit surface defects. Because the light intensity at the edge of the spherical fruit is lower than that in the middle, the defects on the surface of the fruit cannot be effectively identified. In this paper, a hyperspectral online sorting device for the whole surface of spherical fruits is proposed. The correction of light intensity of spherical fruits is realized by using spectral characteristic peaks and the Non-uniformity Correction based on Quadratic Curve Fitting (QCF). First of all, the image data of navel orange was collected by online detection sorting equipment and the spectral image of the characteristic wave peak of 1655.72 nm was extracted. Then, the light intensity at the edge of the spherical fruit is enhanced by Non-uniformity Correction. Finally, the corrected image is segmented by the threshold to obtain surface defects. Ultimately, the online sorting test is carried out, and the detection accuracy is 100%. For defective navel oranges, the number of defect pixels after light intensity enhancement is effectively improved compared with that before light intensity enhancement. This indicates that this method not only overcomes the defect of the uneven light intensity distribution of spherical fruit surface images, but also effectively improves the sensitivity of defect detection. At the same time, the dimensionality reduction of hyperspectral data is also carried out, which is conducive to improving the efficiency of online detection.