bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pyrazole as an anti-inflammatory scaffold
Authors: Kaur Parminder , Arora Vimal , Kharb Rajeev 
Published: May 2022

Inflammation is a common component behind pathophysiology of many chronic diseases like cardiovascular, arthritis, bowel disorders, cancer, chronic wounds, and lesions which are the most significant cause of death in the world, according to the World Health Organization. Chronic inflammation associated diseases are expected to increase persistently by the next 30 years as 3 of 5 people die daily due to chronic inflammatory diseases. So, the prerequisite of novel anti-inflammatory agents has been noteworthy increased than ever. Heterocyclic compounds are being developed at the large pace over the most recent couple of decades due to their intriguing pharmacological activities. The most remarkable and well-known heterocyclic nucleus is pyrazole which has pulled the consideration of numerous specialists to explore its wide potential. Pyrazole derivatives are considered as valuable class of compounds owing to their extremely noticeable anti-inflammatory activity. This review delivers a vast summary of pyrazole derivatives developed last decade for their action against inflammation along with docking studies with a hope that it will be useful for medicinal chemists working in anti-inflammatory drug development.
Sex determination by using mesiodistal dimensions of anterior teeth in Punjab population
Authors: Jatana Indrani , Arora Bhavana , Goyal Deepak , Grewal Tejbir Singh , Dugal Sukhman 
Published: May 2022

Aim: Sex determination by Using Mesiodistal Dimensions of Anterior Teethin Punjab population. Methods: This study had a total of 60 study individuals who were chosen at random. The patients ranged in age from 18 to 30 years old, with no history or clinical signs of crown repair, orthodontic therapy, or trauma. They had a full set of erupting teeth. The teeth were noncarious, nonattrited, intact, and peridontally healthy. All of the maxillary teeth were properly positioned. Following informed permission, the mesiodistal dimensions of maxillary front teeth were measured between anatomic contact sites using a vernier calliper held parallel to the occlusal plane. Results: The study's findings revealed that teeth 13 and 23 had sexual dimorphism, but teeth 11, 12, 21, and 22 had no statistically significant sexual dimorphism. The precision with which gender may be determined using 13. It was discovered that 13 (43.33 percent) females and 15 (50 percent) males were accurately categorised. When the degree of accuracy for sex determination was examined using 23 unique males and females, it was discovered that 63.33 percent of females and 63.33 percent of males were accurately categorised.
Evaluation of the relationship with quality and disability adjusted life years, pertaining to road traffic injuries and maxillofacial trauma associated with risky driving behavior among adult population in trichy district
Authors: Prashanthy M. R. , Dhamodhar Dinesh , Prabu D. , Rajmohan M. , Bharathwaj V. V. , Sindhu R. , Suganya P. 
Published: May 2022

To determine the influence of risky driving behaviour on road traffic injuries and maxillofacial injuries. In addition, to assess the quality-adjusted life years (QALY) among the adult population. A hospital-based cross-sectional study was conducted among 504 patients using a multiphase random sampling technique to determine road traffic accident cases among the adult population across different government hospitals in Trichy. The Manchester driving behaviour questionnaire were used to collect the data for risky driving behaviour. The quality-adjusted life years was evaluated with 15D questionnaire. Based on the formula for calculating the QALY, it is obtained from the scores. Principal component analysis was used for the reduction factor for the questionnaire, and it was reduced to a 15-D questionnaire. Chisquare test and Pearson correlation test were used to found out the statistical analysis between the variables. The correlation between quality-adjusted life-years questionnaire among the two and four-wheeler riders. P-value was found to be statistically significant for maximum variables recorded in the study, which includes hearing (0.025), breathing (0.015), sleeping (0.035), discomfort and symptoms (0.023), distress (0.012), depression (0.034), vitality (0.031). The present study concluded that subjects with maxillofacial injuries and other bodily injuries were affected the patient’s quality of life.
study of left ventricular diastolic dysfunction as an early predictor of cardiovascular disease in patients with type 2 diabetes mellitus
Authors: Chidananda V. , Pramod K. , Reddy Chikkanarasa , Madappa Divyaprakash , Sreeranga P. C. 
Published: May 2022

Diabetes Mellitus (DM) is a disease with multi-system complications. Left ventricular diastolic dysfunction (LVDD) is an early stage of diabetic cardiomyopathy that can develop to heart failure. It has no clinical symptoms and can be easily diagnosed with echocardiography. The study aims to evaluate the LVDD in Type-2 DM with no symptoms of cardiovascular disease and its association with glycaemic control (HbA1c), DM duration, and microangiopathy. The cross-sectional hospital-based study included 100 asymptomatic patients with type 2 DM without evidence of cardiovascular involvement were studied. LVDD was evaluated by doppler echocardiography, which included E/A ratio, assessed in relation with age, sex, duration of diabetes and HbA1c level. LVDD was present in 57 % of the type 2 DM patients with males accounting for the majority of cases (63.2%). Diastolic dysfunction was more common in patients on oral hypoglycaemic agents (78%), insulin (2%) and/or both (19%). There was a linear progression of diastolic dysfunction with the increase age group (P = 0.001). LVDD was significantly associated with uncontrolled diabetes as measured by HbA1c levels with higher number patients among HbA1c >8.5 (71.9%; P = 0.001) and a longer duration of DM with highest among 6 -10 years (38.6%; P = 0.001).
PORTRAYAL OF GISELLE’S CHARACTER IN “ENCHANTED” MOVIE: A GENDER STEREOTYPE STUDY
Authors: Dewi Rizqia Lutfi Kurnia , Muhid Ahmad , Kurniadi Didit 
Published: May 2022

Enchanted (2007) is a musical romantic comedy movie produced by Walt Disney Pictures that combine animated and live action scenes. The movie has interesting characters and plot to analyze. This study examines Giselle’s character in Disney’s Enchanted movie, the connection with gender-role stereotypes, and the moral values from the story. Data were collected by using library research method and analyzed through structural approach and coded content analysis approach based on coding characteristics. Results showed that Giselle has more feminine than masculine characteristics that confirm the female gender-role stereotype. However, a twist at the climax of the story displaying her acquired masculine traits indicates the rise of modern female-gendered representation from Disney. Further studies are needed to investigate the development of the dynamic character related to Disney’s gender-role message and the influences to today society life.
Análise da Meta-Análise C19
Authors: Padrão Eduardo , Marchini Julio Flávio Meirelles , Bittencourt Marcio Sommer 
Published: May 2022

Atualmente existem diversos estudos com conhecimentos científicos gerados diariamente. Devido a isso, é natural que haja materiais com qualidades diversas. Torna-se então, indubitável a necessidade da interpretação crítica de artigos científicos, sendo que esta habilidade deve ser aprimorada na residência médica – incluindo a de medicina de emergência. Com o cenário da pandemia de COVID-19, surgem então novos materiais na tentativa de elucidar diversos fatores envolvendo, por exemplo, profilaxia e tratamento, fatos que devem ser analisados de forma coerente, para evitar falhas nesses aspectos de avaliação e interpretação. O presente trabalho visa realizar análises detalhadas, divididas em duas partes, acerca dos resultados publicados no site C19legacy.com, relacionados à meta-análise sobre os possíveis efeitos da Ivermectina na COVID-19. A primeira parte envolve uma análise imparcial seguindo a declaração PRISMA, publicada em 2009, como documento guia para melhor qualidade de revisões sistemáticas e meta-análises. A segunda parte envolve uma análise crítica da meta-análise em questão.
Pheno-thermal response of exotic high density apple varieties under temperate conditions of Kashmir
Authors: QAYOOM SAMEERA , MUSHTAQ NIGHAT , ROHITASHW KUMAR  , AHMAD LATIEF , LONE B.A. , SINGH PURSHOTAM , PANDIT ASHAQ , YOUSUF WAJAHAT , BHAT KHALID 
Published: May 2022

The present study evaluated the effect of mean temperature and rainfall on phenology attainment of twenty cultivars of apple grown temperate region of Kashmir, India during 2018 and 2019. The results showed that increase in accumulated heat units decreased the time for attainment of phenological stages. The minimum requirement of heat units were recorded in Elstar (17 day 0C), Jona gold (18 day 0C) and Red braeburn (18 day 0C) for attainment of silver tip stage while as dormancy break was recorded earliest in cv. Red braeburrn and Red velox. The attainment of pink bud stage was recorded earliest in Red delicious followed by Elrosa and Gala redlum. However, fruit setting was found earlier in cv. Jona gold (50.1 day 0C) and late in Gala redlum and Gala mast. Highest heliothermal units were found in cv. Gala Mast (478 day 0C h) and Braeburn (461 day 0C h) and lowest in Jona gold (336 day 0C h) while as maximum hydrothermal units were found in Gala red (484 day 0C h) and Gala mast (471 day 0C h). Yield and yield associated traits were also found significantly influenced by accumulated heat units with maximum yield recorded in cv. Golden clone B (90.54 t ha-1) followed by Gala redlum (75.93 t/ha) and Red chief (71.13 t ha-1) with maximum heliothermal use efficiency (0.22), heat use efficiency (1.46) and hydrothermal use efficiency (0.22), respectively.
BANKING PROJECT FINANCING OF PUBLIC-PRIVATE PARTNERSHIP AND ITS ROLE IN ENSURING PUBLIC WELFARE
Authors: Shuliuk Bohdana , Horyn Volodymyr 
Published: May 2022

The article reveals the peculiarities of the use of bank project financing in the field of PPP. It is substantiated that the peculiarity of the application of PPP project financing is the creation of a special project company, which is responsible for mobilizing financial resources for project implementation; the presence of a hierarchy of investment; more objective assessment of the borrower's solvency and reliability and evaluation of the project itself in terms of its efficiency, security and risk; significant transaction costs to settle the interests of all members of the partnership.
It is proved that in modern conditions the role of project bank lending in the sources of project financing is growing rapidly, and the role of banks in this process is much wider than in traditional forms of lending. They not only provide financial support for the project, but also become direct participants in the implementation of the PPP project, performing management, settlement, consulting, guarantee and other functions. Given the specifics of PPP projects (large scale, long implementation time, cost), the participation of commercial banks in their financing is complicated. International development banks and international financial institutions play a leading role in the formation of project financing in the field of PPP, and the syndicated lending mechanism is also used in foreign practice. However, in Ukraine, bank project financing is practically underdeveloped, which is due to its institutional and legal irregularities. The use of syndicated lending mechanisms in Ukraine is unique, as well as the financing of PPP projects through credit and export agencies. PPP project financing with the support of international financial institutions, in particular the EBRD, has been the most developed, concentrating in such areas as infrastructure development, energy reform, and construction. In this regard, the problems of economic, legal and managerial nature, which hinder the development of bank project financing in the field of PPP in Ukraine in modern conditions, are outlined.
Regional Wealth with Biodiversity and Socioeconomic Marginality
Authors: Vázquez-Elorza Ariel 
Published: May 2022

Purpose. Mexico is a country with a richness in biodiversity and a high level of Natural Capital throughout the territory; however, the highest concentration is distributed in regions where a population with high levels of marginalization and socioeconomic poverty lives.
Methodhology. The characteristics of genetic resources and their sustainable use in conservation require the establishment of cross-cutting strategies in the design and implementation of comprehensive public policies focused on society and the diversity of territories and social needs.
Findings and originality. This reality highlights the relevance of identifying the main elements that characterize the Natural Capital in the environments, mainly in the South Pacific region due to its social and cultural importance. The originality of this document is the analysis of the socioeconomic and marginalization conditions of the population with the most incredible wealth in biodiversity and establish strategies that facilitate the conservation of genetic resources in tune with sustainable social and economic growth in the medium and long term.
O papel da cultura organizacional e a nova configuração do trabalho - home office na Amazônia Paraense
Authors: Nunes Caroline Melo , Carvalho Josue de Lima , Ferreira Luciana Rodrigues , Brasileiro Tânia Suely Azevedo , Teixeira Regina Cleide Figueiredo da Silva 
Published: May 2022

O objetivo do artigo é analisar como a cultura organizacional influencia para mitigar o impacto da flexibilização das condições de trabalho de professores de instituições de ensino superior no período da pandemia da covid 19. A questão da pesquisa busca responder: qual o papel da cultura organizacional na implantação do modelo de trabalho home-office de aulas na modalidade Ensino Remoto Emergencial (ERE)? Como categorias de análise teórica, adotou-se abordar a cultura organizacional e a modalidade de teletrabalho em home-office. Como estratégia de pesquisa foi utilizado o método “survey” para analisar como a cultura organizacional no contexto de crise sanitária minimiza os impactos da implantação do home-office em aulas ministradas remotamente por professores de IES públicas e privadas. O instrumento de pesquisa survey foi um questionário com perguntas de escala fechada do tipo Likert, com amostra não probabilística, totalizando 180 respondentes. Constatou-se a formação de dois fatores, Fator 1 "Home-Office" – aspectos que contribuíram para implementação desta modalidade de teletrabalho nas IES’s investigadas e Fator 2 “Cultura Organizacional” – as principais características dos componentes internos da cultura das IES’s da região metropolitana de Belém, na Amazônia paraense, que favoreceram esse processo de implementação do ERE.
Perspectiva de género y condiciones de aprendizajes virtuales en pandemia
Authors: Posso Yépez Miguel , León Ron Verónica , Narváez Olmedo Gabriela , Posso Astudillo Mikaela 
Published: May 2022

The adaptations that higher education had to incorporate as a result of the COVID-19 pandemic revealed several weaknesses, shortcomings, and vulnerabilities present in the teaching-learning process; likewise, the student's difficulties in successfully carrying out their professional training were made evident. Much research, even before this public health emergency, has shown gaps in education in regard to gender, with women often facing the greatest impediments regarding access and opportunities. Therefore, the objective of this research is to determine the level of association between gender and the five variables that make up the conditions of virtual learning in times of pandemic at the Universidad Técnica del Norte (Ecuador). It is a quantitative, cross-sectional, descriptive and correlational study; the universe is 11374; the probabilistic sample is 2,895 students; the instrument used showed a reliability level of 0.8 (Cronbach's Alpha). A statistically significant association (p<.05) was found between the gender of the UTN students and the five variables of learning conditions. It was observed that female students regularly face less favorable study conditions than their male peers.
Las adaptaciones que tuvo que incorporar la educación superior a raíz de la pandemia del COVID-19 revelaron varias debilidades, falencias y vulnerabilidades presentes en el proceso de enseñanza-aprendizaje; asimismo, se evidenciaron las dificultades del estudiante para llevar a cabo con éxito su formación profesional. Muchas investigaciones, incluso antes de esta emergencia sanitaria, han mostrado brechas en la educación con respecto al género, siendo las mujeres quienes enfrentan los mayores impedimentos en cuanto al acceso y las oportunidades. Por ello, el objetivo de esta investigación es determinar el nivel de asociación entre el género y las cinco variables que conforman las condiciones del aprendizaje virtual en tiempos de pandemia en la Universidad Técnica del Norte (Ecuador). Es un estudio cuantitativo, transversal, descriptivo y correlacional; el universo es 11374; la muestra probabilística es de 2895 estudiantes; el instrumento utilizado presentó un nivel de confiabilidad de 0,8 (Alfa de Cronbach). Se encontró una asociación estadísticamente significativa (p<.05) entre el género de los estudiantes de la UTN y las cinco variables de condiciones de aprendizaje. Se observó que las alumnas se enfrentan regularmente a condiciones de estudio menos favorables que sus compañeros varones.
Mejora de los programas de formación inicial docente a partir de la trayectoria personal, académica y profesional del alumnado
Authors: Rodrigo Moriche Mª Pilar , Vasco González Margarita , Gil Pareja David , Pericacho Gómez Javier 
Published: May 2022

To improve initial teacher training programs and favora positive encounter between students and those who design and implement them, it is necessary to have up-to-date information on entry profiles. This article describes the students according to their life experiences, previous knowledge, professional development and learning goals to know opportunities, needs and improvement trends. From a qualitative orientation, 62 initial evaluation tasks were selected for first-year students of the General Didactics subject of the Master's degree in Primary Education at Universidad XXX from the 2014-15 to 2019-20 academic year. The documentary analysis was supported by the computer software Atlas ti 9 from which emerged, through the articulation of the grounded theory, a set of categories whose relationships and interpretations, results were obtained that evidenced, among others: high teaching vocation and ideas preconceived in training and professional interests oriented to educational change. As main conclusions, it is proposed to connect with training and professionalexperiences related to the educational field as precursory teaching elements; promote innovative, participatory and teamwork methodologies; and guide the theory to educational practice and teaching organization.
Para mejorar los programas de formación inicial docente y favorecer un encuentro positivo entre el alumnado y quienes los diseñan e implementan, es necesario disponer de información actualizada sobre los perfiles de entrada. Este artículo describe al alumnado según sus experiencias de vida, conocimientos previos, desarrollo profesional y metas de aprendizaje para conocer oportunidades, necesidades y tendencias de mejora. Desde una orientación cualitativa se seleccionaron 62 tareas de evaluación inicial del estudiantado de primer curso de la asignatura Didáctica General del grado de Maestro/a en Educación Primaria de la Universidad XXX desde el curso 2014-15 hasta 2019-20. El análisis documental fue apoyado por el software informático Atlas ti 9 del que emergieron, por medio de la articulación de la teoría fundamentada, un conjunto de categorías de cuyas relaciones e interpretaciones, se obtuvieron resultados que evidenciaban, entre otros: alta vocación docente e ideas preconcebidas en la formación e intereses profesionales orientados al cambio educativo. Como principales conclusiones se plantea conectar con la formación y experiencias profesionales afines al ámbito educativo como elementos precursores docentes; potenciar metodologías innovadoras, participativas y de trabajo en equipo; y orientar la teoría a la práctica educativa y a la organización docente.
Diseño y validación de un instrumento para la evaluación competencial en el marco del desarrollo profesional docente
Authors: Lluch Molins Laia , Cano Garcia Elena 
Published: May 2022

This paper presents the process of creating an instrument for assessing teaching competences applicable throughout various professional life cycles. After designing and validating a global theoretical framework of the teachers’ key competences, the steps followed for the construction of the rubrics associated with the various competence levels are detailed, as well as the competence perception questionnaires linked to each of the grades of the scale established by the rubric. A pilot application is carried out in order to validate the tools created, in addition to obtaining a first preview of the results of a teacher training program in China. The results, collected in terms of perception of the improvement in competence development, allow us to suggest achievements in the improvement of competence linked to community action, initially low, and in assessment competence. Regarding validation, the data collected, in the absence of further analysis, allow us to see that these are valid rubrics and questionnaires to self-assess the level of competence development and proceed, within the framework of professional development processes, to their continuous improvement.
En este artículo se presenta el proceso de creación de un instrumento de evaluación de las competencias docentes aplicable a lo largo de diversos ciclos de vida profesional. Tras diseñar y validar un marco teórico global de las competencias clave del profesorado, se explican los pasos seguidos para la construcción de las rúbricas asociadas a los diversos niveles competenciales, así como los cuestionarios de percepción competencial vinculados a cada uno de los grados de la escala establecida por la rúbrica. Se procede a una aplicación piloto con el fin de validar las herramientas creadas, además de obtener un primer avance de los resultados de un programa formativo de profesorado de China. Los resultados, recogidos en términos de percepción de la mejora en el desarrollo competencial, permiten insinuar logros en la mejora de la competencia vinculada a la acción comunitaria, inicialmente baja y en la competencia de evaluación. Respecto a la validación, los datos recogidos, a falta de ulteriores análisis, permiten atisbar que se trata de rúbricas y cuestionarios válidos para autoevaluar el nivel de desarrollo competencial y proceder, en el marco de los procesos de desarrollo profesional, a su mejora continuada.