bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking Mechanistic Effects of Pharmaceuticals and Personal Care Products to Ecologically Relevant Outcomes: A Decade of Progress
Authors: Ankley Gerald T. , Berninger Jason P. , Maloney Erin M. , Olker Jennifer H. , Schaupp Christopher M. , Villeneuve Daniel L. , LaLone Carlie A. 
Published: June 2022

Abstract
There are insufficient toxicity data to assess the ecological risks of many pharmaceuticals and personal care products (PPCPs). While data limitations are not uncommon for contaminants of environmental concern, PPCPs are somewhat unique in that an a priori understanding of their biological activities in conjunction with measurements of molecular, biochemical, or histological responses could provide a foundation for understanding mode(s) of action and predicting potential adverse apical effects. Over the past decade significant progress has been made in the development of new approach methodologies (NAMs) to efficiently quantify these types of endpoints using computational models and pathway-based in vitro and in vivo assays. The availability of open-access knowledgebases to curate biological response (including NAM) data and sophisticated bioinformatics tools to help interpret the information also has significantly increased. Finally, advances in the development and implementation of the adverse outcome pathway framework provide the critical conceptual underpinnings needed to translate NAM data into predictions of the ecologically relevant outcomes required by risk assessors and managers. The evolution and convergence of these various data streams, tools, and concepts provides the basis for a fundamental change in how ecological risks of PPCPs can be pragmatically assessed. Environ Toxicol Chem 2024;43:537–548. © 2022 SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Regional and age‐related diversity of human mature oligodendrocytes
Authors: Yaqubi Moein , Luo Julia Xiao Xuan , Baig Salma , Cui Qiao‐Ling , Petrecca Kevin , Desu Haritha , Larochelle Catherine , Afanasiev Elia , Hall Jeffery A. , Dudley Roy , Srour Myriam , Haglund Lisbet , Ouellet Jean , Georgiopoulos Miltiadis , Santaguida Carlo , Sonnen Joshua A. , Healy Luke M. , Stratton Jo Anne , Kennedy Timothy E. , Antel Jack P. 
Published: June 2022

AbstractMorphological and emerging molecular studies have provided evidence for heterogeneity within the oligodendrocyte population. To address the regional and age‐related heterogeneity of human mature oligodendrocytes (MOLs) we applied single‐cell RNA sequencing to cells isolated from cortical/subcortical, subventricular zone brain tissue samples, and thoracolumbar spinal cord samples. Unsupervised clustering of cells identified transcriptionally distinct MOL subpopulations across regions. Spinal cord MOLs, but not microglia, exhibited cell‐type‐specific upregulation of immune‐related markers compared to the other adult regions. SVZ MOLs showed an upregulation of select number of development‐linked transcription factors compared to other regions; however, pseudotime trajectory analyses did not identify a global developmental difference. Age‐related analysis of cortical/subcortical samples indicated that pediatric MOLs, especially from under age 5, retain higher expression of genes linked to development and to immune activity with pseudotime analysis favoring a distinct developmental stage. Our regional and age‐related studies indicate heterogeneity of MOL populations in the human CNS that may reflect developmental and environmental influences.
Relationship between handgrip strength, depression and cognitive functioning among older adults: Evidence from longitudinal ageing study in India
Authors: Muhammad T. , Maurya Priya 
Published: June 2022

AbstractBackgroundHandgrip strength (HGS) is a frequent and general indicator of muscle strength and it may affect several aspects of mental health among older people. This study explored the association of HGS with depression and cognitive impairment among community‐dwelling older adults in resource‐constrained setting of India.MethodData were drawn from the Longitudinal Ageing Study in India (LASI), and the analysis was conducted on 27,707 older adults aged 60 years and above. Outcome measures included depression (assessed by the Short Form Composite International Diagnostic Interview (CIDI‐SF) and the Center for Epidemiological Studies‐Depression (CES‐D) scales) and cognitive impairment. Descriptive statistics and mean scores of HGS were reported and multivariable linear regression analyses were conducted to test the research hypotheses of the study.ResultsMean score of HGS was 24.33 (SD: 7.22) for males and 15.94 (SD: 5.14) for females. Mean age was 68.86 (SD: 7.19) and 68.40 (SD: 7.31) years among males and females respectively. Older participants who had weak HGS were significantly more likely to be depressed in CIDI‐SF scale (B: 0.06, CI: 0.01–0.13) and CES‐D scale (B: 0.02, CI: 0.01–0.03) in comparison to those who had strong HGS after adjusting for a large number of confounders. Older participants who had weak HGS were significantly more likely (B: 0.92, CI: 0.76–1.07) to have cognitive impairment compared to those who had strong HGS.ConclusionThe findings highlight the independent association of HGS with major depression, depressive symptoms and cognitive impairment that have implications on promoting resistance‐training programs among aged population.
Cognitive outcomes are differentially associated with depression severity trajectories during psychotherapy treatment for late life major depressive disorder
Authors: Kassel Michelle T. , Rhodes Emma , Insel Philip S. , Woodworth Kai , Garrison‐Diehn Christina , Satre Derek D. , Nelson J. Craig , Tosun Duygu , Mackin R. Scott 
Published: June 2022

AbstractObjectivesLate Life Depression (LLD) is associated with persistent cognitive dysfunction even after depression symptoms improve. The present study was designed to examine cognitive outcomes associated with the pattern of depression severity change during psychotherapy intervention for LLD.Methods96 community‐dwelling adults ages 65–91 with major depressive disorder completed 12 sessions of Problem‐Solving Therapy at the University of California, San Francisco. Nonlinear trajectories of depression severity ratings using the Hamilton Depression Rating Scale were computed from multiple time points collected throughout the weekly psychotherapy intervention. Performance on measures of cognition (information processing speed, executive functioning, verbal learning, memory) was assessed at baseline and post‐treatment. Linear mixed‐effects models examined associations between nonlinear depression severity trajectories and post‐treatment change in cognitive performance.ResultsBroadly, different patterns of depression change during treatment were associated with improved cognition post‐treatment. Greater and more consistent interval improvements in depression ratings were differentially associated with improvements in aspects of verbal learning, memory, and executive function post‐treatment, while no associations were found with information processing speed.ConclusionsThe heterogeneity of depression trajectories associated with improved cognitive outcomes suggests that the temporal pattern of depression response may impact specific cognitive processes distinctly. Results suggest that use of nonlinear depression severity trajectories may help to elucidate complex associations between the time course of depression response and cognitive outcomes of psychotherapy in LLD. These findings have important implications for identifying treatment targets to enhance clinical and cognitive outcomes of psychotherapy in LLD.
Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis
Authors: Vijayakumar Archana , Okesli‐Armlovich Ayse , Wang Ting , Olson Isabel , Seung Minji , Kusam Saritha , Hollenback David , Mahadevan Sangeetha , Marchand Bruno , Toteva Maria , Breckenridge David G. , Trevaskis James L. , Bates Jamie 
Published: June 2022

Abstract
Dysregulated hepatocyte lipid metabolism is a hallmark of hepatic lipotoxicity and contributes to the pathogenesis of nonalcoholic steatohepatitis (NASH). Acetyl CoA carboxylase (ACC) inhibitors decrease hepatocyte lipotoxicity by inhibiting de novo lipogenesis and concomitantly increasing fatty acid oxidation (FAO), and firsocostat, a liver‐targeted inhibitor of ACC1/2, is under evaluation clinically in patients with NASH. ACC inhibition is associated with improvements in indices of NASH and reduced liver triglyceride (TG) content, but also increased circulating TG in subjects with NASH and preclinical rodent models. Here we evaluated whether enhancing hepatocyte FAO by combining ACC inhibitors with peroxisomal proliferator‐activated receptor (PPAR) or thyroid hormone receptor beta (THRβ) agonists could drive greater liver TG reduction and NASH/antifibrotic efficacy, while ameliorating ACC inhibitor–induced hypertriglyceridemia. In high‐fat diet–fed dyslipidemic rats, the addition of PPAR agonists fenofibrate (Feno), elafibranor (Ela), lanifibranor (Lani), seladelpar (Sela) or saroglitazar (Saro), or the THRb agonist resmetirom (Res), to an analogue of firsocostat (ACCi) prevented ACCi‐induced hypertriglyceridemia. However, only PPARα agonists (Feno and Ela) and Res provided additional liver TG reduction. In the choline‐deficient high‐fat diet rat model of advanced liver fibrosis, neither PPARα (Feno) nor THRβ (Res) agonism augmented the antifibrotic efficacy of ACCi. Conclusion: These data suggest that combination therapies targeting hepatocyte lipid metabolism may have beneficial effects on liver TG reduction; however, they may not be sufficient to drive fibrosis regression.
Unsteady MHD free convective flow past a moving vertical plate in a porous medium with radiation and chemical reaction including arbitrary thermal and solutal ramped condition
Authors: Ahmed Nazibuddin , Saikia Dibya Jyoti 
Published: June 2022

AbstractThe motive behind this investigation is to examine the unsteady magnetohydrodynamics free convective fluid flow with heat and mass transfer of a viscous, incompressible flow past a moving upright plate in a porous medium with radiation, chemical reaction, arbitrary thermal, and solutal ramped condition. An analytical solution for momentum, energy, and concentration equations is accomplished by implementing the Laplace transformation technique. The influence of different nondimensional parameters on fluid velocity, temperature, and concentration along with skin friction and rate of heat transfer as well as mass transfer at the plate are exhibited graphically. It can be spotted that both the concentration and temperature field decrease for rising values of the ramped parameter, radiation parameter, chemical reaction parameter, and Schmidt number. Moreover, it is detected that the fluid velocity drops in the case of the isothermal plate, and velocity upsurges for the ramped plate temperature. Investigation simulates that the rate of heat transfer, as well as rate of mass transfer, is escalated on hiking radiation parameter.
Uncertainties and green bond markets: Evidence from tail dependence
Authors: Lin Boqiang , Su Tong 
Published: June 2022

AbstractMotivated by a lack of studies related to macro risk‐driven green bond markets, this paper detects the tail dependence of the USA and China green bond markets on three uncertainty indicators. We applied a novel cross‐quantilogram method to address this issue and utilised the quantile causality test for robustness, as well as to capture predictive causalities. The results show that three selected uncertainty indicators are important drivers for the returns and volatilities of green bond markets. However, all three indicators play different roles in the two nations. The most influential determinant of US green bonds is financial uncertainty, whereas in China, it is economic policy uncertainty. Additionally, the impact on green bond returns varies in different market states, and green bond volatilities may respond abnormally to extreme increasing changes in these uncertainties. These findings imply the unique financial characteristics of two green bond markets and heterogeneities between different countries. The corresponding investment implications and policy significance are discussed in detail in the concluding section.
Biochar stimulates tomato roots to recruit a bacterial assemblage contributing to disease resistance against Fusarium wilt
Authors: Jin Xue , Bai Yang , Khashi u Rahman Muhammad , Kang Xiaojun , Pan Kai , Wu Fengzhi , Pommier Thomas , Zhou Xingang , Wei Zhong 
Published: June 2022

AbstractBiochar amendment is acknowledged to favor plant resistance against soil‐borne diseases. Although plant‐beneficial bacteria enrichment in the rhizosphere is often proposed to be associated with this protection, the mechanism behind this stimulating effect remains unelucidated. Here, we tested whether biochar promotes plants to recruit beneficial bacteria to the rhizosphere, and thus develop a disease‐suppressive rhizosphere microbiome. In a pot experiment, biochar amendment decreased tomato Fusarium wilt disease severity. Using a transplanting rhizosphere microbiome experiment, we showed that biochar enhanced the suppressiveness of tomato rhizosphere microbiome against Fusarium wilt disease. High‐throughput sequencing of 16S ribosomal RNA gene and in vitro cultures further indicated that the recruited suppressive rhizosphere microbiome was associated with the increase of plant‐beneficial bacteria, such as Pseudomonas sp. This amendment also enhanced the in vitro chemoattraction and biofilm promotion activity of tomato root exudates. Collectively, our results demonstrate that biochar amendment induces tomato seedlings to efficiently recruit a disease‐suppressive rhizosphere microbiome against Fusarium wilt.
Implementing genomics in the neonatal period: An assessment of parental decision making and anxiety
Authors: Wainstein Tasha , Campbell Teresa , Stojkova Biljana J. , Lavoie Pascal M. , Elliott Alison M. 
Published: June 2022

AbstractAs uptake of rapid genome sequencing (GS) in the neonatal period steadily increases, a clinical genetics service that is optimized to the needs of parents becomes increasingly important. We aimed to investigate factors that influence decision making about rapid GS by parents of infants admitted to neonatal intensive care units (NICU) and explore their experiences of decisional conflict and anxiety during this time. Parents of neonates suspected of having a genetic disorder and offered rapid GS in the NICU completed a questionnaire measuring experience with GS counseling, decisional conflict, and anxiety level. Our results demonstrate that despite a largely positive GS experience (70%; 21/30) among the survey respondents, 50.0% (14/28) experienced moderate to severe anxiety measured using the GAD‐7 scale, and 34.6% (9/26) experienced decisional conflict measured using the SURE scale. We also showed that prematurity may be a modifier of anxiety in this group of parents and although not statistically significant, distance lived away from the hospital site could have practical significance. Open‐ended responses to survey questions highlighted that feeling overwhelmed, the types of engagements parents had with healthcare providers, and the timing of information provision also influenced parental decision making in this setting. We suggest that the GAD‐7 scale for generalized anxiety and SURE scale for decisional conflict could be incorporated by genetic counselors into routine care of parents of neonates who have been offered rapid GS to identify those who may need additional support (resources, information, or psychological). These tools may inform ways that communication between patients and providers can be improved and enhanced and clinical genetics services in the NICU can be optimized. We suggest that integrating genetic counselors into the NICU care team could increase access for this population and ensure delivery of optimized patient education and counseling.
Irreducible nonmetrizable path systems in graphs
Authors: Cizma Daniel , Linial Nati 
Published: June 2022

AbstractA path system in a graph is a collection of paths with a unique path for every two vertices . We say that is consistent if for any path , every subpath of is also in . It is metrizable if there exists a positive weight function such that is comprised of ‐shortest paths. We call irreducible if there does not exist a partition such that restricts to a path system on both and . In this paper, we construct an infinite family of nonmetrizable irreducible consistent path systems on certain Paley graphs.
Amide Proton Transfer‐Weighted Imaging Combined With Intravoxel Incoherent Motion for Evaluating Microsatellite Instability in Endometrial Cancer
Authors: Ma Changjun , Tian Shifeng , Song Qingling , Chen Lihua , Meng Xing , Wang Nan , Lin Liangjie , Wang Jiazheng , Liu Ailian , Song Qingwei 
Published: June 2022

BackgroundMicrosatellite instability (MSI), caused by mismatch repair (MMR) protein defects that lead to uncorrectable mismatch bases, results in the accumulation of gene mutations and ultimately to tumors. Preoperative prediction of MSI can provide a basis for personalized and precise treatment of endometrial cancer (EC) patients.PurposeTo investigate amide proton transfer weighting (APTw) imaging combined with intravoxel incoherent motion (IVIM) in the assessment of MSI in EC.Study TypeRetrospective.PopulationA total of 71 patients with EC (12 classified as the MSI group and 22 as the microsatellite stabilization [MSS] group after entering and leaving the group standard).Field Strength/SequenceA 3.0 T/IVIM, diffusion‐weighted imaging (DWI) and APTw.AssessmentAmide proton transfer (APT) value, apparent diffusion coefficient (ADC), pure diffusion coefficient (D), pseudo diffusion coefficient (D*), and perfusion fraction (f) were calculated and compared between MSI and MSS groups.Statistical TestsThe Kendall's W test; Mann–Whitney U‐test; Chi‐square test or Fisher's exact test; logistic regression analysis; Area under the receiver operating characteristic (ROC) curve (AUC); The Delong test; Pearson or Spearman correlation coefficients. The significance threshold was set at P < 0.05.ResultsAPT and D* values of the MSI group were significantly higher than those of the MSS group. While ADC, D, and f values in the MSI group were significantly lower than those in the MSS group. The multivariate analysis revealed that only APT and D* values were independent predictors to evaluate the MSI status. And the ROC curves indicated that the combination of APT and D* values could distinguish the MSI status of EC with the highest diagnostic efficacy (AUC = 0.973), even without significant difference to those by APT (AUC = 0.894) or D* (AUC = 0.920) value separately (P = 0.149 and 0.078, respectively).ConclusionCombination of APTw and IVIM imaging may serve as an effective noninvasive method for clinical assessment of MSI in EC.Evidence Level3Technical EfficacyStage 2
Does a stick work? A meta‐analytic examination of curvilinear relationships between job insecurity and employee workplace behaviors
Authors: Jiang Lixin , Lawrence Amy , Xu Xiaohong (Violet) 
Published: June 2022

SummaryThe job insecurity literature has been limited by the dominant linear view on the effects of job insecurity and the misconception that the conceptualizations and operationalizations of job insecurity across studies are homogenous. To challenge these two assumptions, we contrast the integrated perspective based on social exchange theory and job preservation motivation with activation theory and propose competing hypotheses for the curvilinear relationships between job insecurity and employee behavioral outcomes, including task performance, organizational citizenship behavior (OCB), creative performance, safety behavior, and counterproductive work behavior (CWB). We also examine the moderating roles of different conceptualizations of job insecurity (i.e., cognitive vs. affective job insecurity; quantitative vs. qualitative job insecurity) in the proposed curvilinear relationships. Our meta‐analysis demonstrates that the negative relationships of job insecurity with task performance and OCB‐organization turn positive after inflection points, supporting the integrated perspective of social exchange theory and job preservation motivation but not activation theory. Moreover, the negative relationships of job insecurity with OCB‐individual and creative performance turn nonsignificant as job insecurity further increases. Finally, job insecurity has a linear, negative relationship with safety behavior, but a linear, positive relationship with CWB‐organization. Interestingly, affective job insecurity has lower inflection points than cognitive job insecurity, and qualitative job insecurity has lower inflection points than quantitative job insecurity. This study provides a deep and fine‐grained understanding of the curvilinear relationships between job insecurity and workplace behaviors and pushes the literature forward by focusing on the nuanced differences among various types of job insecurity.
Microimage coupled Raman optical probes for benthic solid target detection
Authors: Liu Qingsheng , Guo Jinjia , Lu Yuan , Liu Shuang , Nie Mingzhao , Wei Zihao , Ye Wangquan , Zheng Ronger 
Published: June 2022

AbstractOver the past decades, Raman spectroscopy has been proven to be a powerful tool for in situ detection in the deep sea. However, two important issues are usually presented for solid detection of Raman in the sea: (a) The implementation of accurate laser focusing using the manipulator of remotely operated vehicles is difficult; (b) it is challenging to recognise minerals by Raman only. In this study, a novel approach was presented to address these difficulties by introducing microimage into underwater Raman system to aid laser focusing and spectra analysis. The further evaluation results showed that, using 5× objective lens, the joint system could obtain the focused laser spot size of 290 μm on the focal plane for Raman detection and the spatial resolution of 2.2 μm for the microimaging. With the aid of microimaging, the Raman probe was successfully applied to the China Yellow Sea (36.129°N, 120.215°E) for in situ detection on the seafloor. Microimaging is a practical method of promoting the detection ability of underwater Raman spectroscopy, and biological applications would be another perspective in the future.