bluuebunny/crossref_metadata_2025_split huggingface dataset:
The senolytic ABT-263 improves cognitive functions in middle-aged male, but not female, atherosclerotic LDLr−/−;hApoB100+/+ mice
Authors: Lambert Mélanie , Miquel Géraldine , Villeneuve Louis , Thorin-Trescases Nathalie , Thorin Eric 
Published: February 2025

Abstract
Accumulation of cerebral senescent cells may compromise the continuum between vascular and neuronal function, leading to damage and cognitive decline. Elimination of senescent cells might therefore preserve vascular and neuronal functions. To test this hypothesis, we used male and female atherosclerotic LDLr−/−;hApoB100
+/+ mice (ATX-mice), a model of vascular cognitive impairment (VCI), treated with the senolytic ABT-263 for 3 months (3- to 6-month or 9- to 12-month old). In young male ATX mice, prevention with ABT-263 improved spatial retention memory, in association with a higher endothelial sensitivity to shear stress and a higher hippocampal CD31+ endothelial cell density, lower activation of both astrocytes and glial cells. In young females, ABT-263 tended to improve delayed memory; however, atherosclerotic plaque was magnified by ABT-263, endothelial function was unaffected, hippocampal astrocyte activation increased and expression of CD31+ cells decreased. Hence, unlike in males, ABT-263 appears deleterious in young ATX females. In middle-aged males, the curative treatment improved the learning process and memory. Although no change in endothelial function was observed, the benefits of ABT-263 were associated with a decreased expression of several inflammaging markers, a higher density of CD31+ cells and a lower activation of glial cells. In middle-aged females, ABT-263 induced a surge of inflammaging markers, associated with a slower learning process. Altogether, our data demonstrate that ABT-263 differentially affects VCI, improving cognition in male while being deleterious in female ATX mice. More studies are needed to understand the mechanisms at the basis of the sexual dimorphic effects of the senolytic ABT-263.
Demenzsensible Kunstvermittlung in Museen – Konzeption und Evaluation einer Schulung im Projekt Erinnerungs_reich
Authors: Rettich Annika , Bothur Martina , Petermann Jenny , Schall Arthur , Wächter Michael , Voigt Karen 
Published: February 2025

Zusammenfassung

Hintergrund
Neben primär demenzspezifischen Symptomen sind viele Menschen mit Demenz zusätzlich durch soziale Isolation belastet. Um die soziale und kulturelle Teilhabe dieser vulnerablen Bevölkerungsgruppe im Museumssetting zu steigern, hat das Projekt Erinnerungs_reich – Museen als Medizin für Menschen mit Demenz Multiplikatorenschulungen mit Train-the-Trainer-Ansatz entwickelt, durchgeführt und evaluiert, um die teilnehmenden Kunstvermittler:innen zur Durchführung demenzsensibler Museumsangebote zu befähigen. Wie zufrieden waren die Kunstvermittler:innen mit den Schulungen und welche Änderungen wurden vorgenommen, um die Schulungen passfähiger zu gestalten?

Methode
Die vier Schulungen fanden im Frühjahr/Sommer 2023 in Dresden, Görlitz, Freiberg und Leipzig statt. Abschließend konnten die Schulungsteilnehmenden im Rahmen einer begleitenden formativen Evaluation verschiedene Schulungsaspekte auf einer sechsstufigen Likert-Skala von sehr zufrieden bis sehr unzufrieden sowie im Freitextformat bewerten.

Ergebnisse
Insgesamt nahmen 51 Kunstvermittler:innen aus 33 Museen an den Schulungen teil (75 % weiblich, M = 41,1 Jahre). Die Bewertungen zeigten mehrheitlich einen starken Zuspruch: 74 % der Evaluationsteilnehmenden waren mit den Schulungen insgesamt sehr zufrieden. Durch die Evaluation nach der ersten der vier Schulungen ließen sich die Möglichkeit zum kollegialen Austausch und der Praxisanteil als vergleichsweise verbesserungswürdig identifizieren. Durch gezielte Anpassungen für die darauf folgenden Schulungen konnte eine verbesserte Bewertung dieser Aspekte erreicht werden.

Diskussion
Die Multiplikatorenschulungen bieten durch das Train-the-Trainer-Prinzip und die praxisnahe, zielgruppenangepasste Gestaltung einen Ansatz, um Kunstvermittler:innen nachhaltig für die besonderen Bedürfnisse von Demenzbetroffenen zu sensibilisieren und zur Durchführung demenzsensibler Museumsangebote zu befähigen. Die hohe Nachfrage und die positiven Bewertungen verdeutlichen das Interesse und den Bedarf an demenzsensiblen Schulungsangeboten – in kulturellen Bereichen und darüber hinaus.
Analysis of the t′ + c Phase Content from ZrO2-16 Mol.% Y2O3-16 Mol.% Ta2O5 Mechanoactivated Powder Mixtures in Coatings Deposited by Suspension Plasma Spraying
Authors: Galeano-Camacho Catalina , Bedoya-Trujillo Iván , Pérez Sebastián , Ageorges Hélène , Muñoz-Saldaña Juan 
Published: February 2025

Abstract
Gas turbines or power generation engines used in transportation, defense, and energy sectors use thermal barrier coatings (TBCs) to protect metallic components exposed to high-temperature conditions. This work focuses on the in situ synthesis during coating deposition by suspension plasma spraying (SPS) from powders mechanoactivated by high-energy ball milling of ZrO2-16 mol.% YO1.5-16 mol.% TaO2.5 (16YTZ) for applications in TBCs. This composition is expected to present a non-transformable tetragonal phase (t′ phase), suitable to overcome the thermodynamic limits of the mostly used conventional 6-8 wt.% yttria stabilized zirconia (YSZ). The 16YTZ powder mixtures were mechanoactivated by either planetary ball milling (240 RPM) and high-energy ball milling (1700 RPM). These mechanoactivated powders were used to obtain densified samples through sintering at 1500 °C for 2 and 20 h, as well as to deposit coatings by SPS at a stand-off distance between 60 and 80 mm using Ar/He as the plasma forming gas. The ceramics and coatings were characterized by XRD, SEM, and Raman spectroscopy. The densified ceramics showed a high t′ phase content, i.e., > 98% of the 16YTZ system, with an average tetragonality of 1.0267. Coatings deposited at a stand-off distance of 60 mm, and a deposition rate of 33 µm/min, present a porosity of less than 5%, and a tetragonality of 1.0187, which is higher than that of standard YSZ coatings. Phase quantification by Rietveld refinement revealed a multiphase condition as result of the heat transfer in the plasma plume leading to in situ synthesis of the ZrO2 base solid solutions, formed by 89.2 wt.% of t′ + c phases (48.4 and 40.8 wt.% of t′ and c-ZrO2, respectively) 8.1% monoclinic ZrO2, 2.4% cubic Y2O3 and 0.4% orthorhombic Ta2O5 on average. Achieving a high percentage of t' + c phases in the coating with a porosity of less than 5% is a significant accomplishment. This success is closely linked to the fact that tetragonality exceeds that of YSZ. These results provide a solid foundation for future experimental designs aimed at optimizing spray parameters.
Effectiveness of Adjuvant Semaglutide Following Bariatric Metabolic Surgery
Authors: Ferguson Jorgen , Fisher Oliver , Talbot Michael , Rigas Georgia 
Published: February 2025

Abstract

Background
Obesity is a relapsing condition and response to anti-obesity therapies appears to be normally distributed. Therefore, some patients undergoing metabolic bariatric surgery (MBS) will demonstrate a partial response to therapy. When prescribing therapies to patients living with obesity (PwO) the median total weight loss (TWL) gives a good indication of the likely utility of prescription for that individual. GLP-1 agonists (GLP1a) offer patients a reasonable prospect of clinically significant weight loss even if they have been previously treated with MBS.

Methods
A retrospective review of prospectively collected data in a single bariatric clinic was performed. Patients with insufficient weight loss at any time point were offered semaglutide therapy with doses titrated depending on response to treatment, tolerability, availability and affordability. Duration of therapy, highest dose tolerated, anthropometric measures and reported side effects were recorded. Reasons for discontinuation were noted where possible; however, discontinuation due to medication unavailability was not reliably captured in the dataset.

Results
The median dose tolerated was 1 mg s/c per week, and 78% tolerated ≤ 1 mg as the maximum achieved dose. The median TWL was 7.5% and side effects were uncommon. Most patients took therapy for > 6 months, but continued therapy > 1 year was uncommon.

Conclusion
Overall ‘real-world’ utility of semaglutide after MBS may potentially be hampered by supply and cost issues more than issues associated with effectiveness or side effect profile.
God’s Kenotic Love-Power – a Defense of Relational Theology and the Vulnerability in Love
Authors: Langby Lina 
Published: February 2025

Abstract
This article presupposes that God should, first and foremost, be understood as essentially loving. From this, this article constructively proposes divine power as kenotic love-power for the Other and shows how this is coherent with different forms of theism. Such love-power always promotes the well-being of the Self-Other in a mutually loving relationship without connotations of self-negation or self-humiliation often associated with kenosis. If love is primary, theists should seek relational theology where God and creation relate to each other and affect each other. Panentheism is one example of relational theology, and so is open theism. Pantheism, on the other hand, is incoherent with the suggested notion of relational kenotic love-power. Several theologians argue that God necessarily loves the world and that God’s love is kenotic. However, kenosis is connected to ideas of self-negation and emptying of the self. From a feminist perspective, this is problematic. This article constructively puts forward an understanding of kenotic love-power that takes this feminist critique seriously and suggests that divine loving power should be understood not as self-limitation or self-abnegation but as self-realization through love and acceptance of that which is Other. It suggests a necessary Self-Other relationship because, without the Self, the Other cannot be. If that were so, there could not be a relationship at all. This model suits panentheists, process-panentheists, and open theists but not pantheists.
Particulate Organic Carbon Scarcity Exacerbates Vulnerability of the Sacramento-San Joaquin Delta Ecosystem
Authors: Mathers Madison A. , Bergamaschi Brian A. , Hernes Peter J. 
Published: February 2025

Abstract
Anthropogenic climate change on local to global scales has transformed the cycling of particulate organic carbon (POC) in river deltas. Understanding the biogeochemical processing of POC across deltas is key to developing a predictive framework for disruptions in carbon cycling within vulnerable ecosystems. This study examined the spatial and temporal variations in POC, particulate nitrogen (PN), and total suspended sediments (TSS) concentrations across the Sacramento-San Joaquin Delta (Delta) over three water years (2021–2023), covering drought-like conditions observed in spring, summer, and fall. Comprehensive Delta-wide surveys were conducted, employing a mass balance model to estimate total POC flux and constrain POC influx/efflux. Limited seasonal variability in POC and PN concentrations reflected a constrained particle supply under hydrologic conditions increasingly representative of the Delta’s future. Results revealed an 81% decrease in annual total suspended sediment concentration inputs to the Sacramento River from the 1957 water year compared to the average of 2021–2022, with levels during the study period much lower than previous decades. POC influx ranged from 39 to 79% of total efflux during spring to fall of low water years, with 8 to 37% of daily POC flux diverted to southern water pumping stations, limiting opportunities for particle deposition and internal production within the Delta. This was reflected in average Delta POC concentrations: 0.77 mg/L (2021), 0.54 mg/L (2022), and 0.42 mg/L (2023). The sustained reduction in sediment and POC levels in the Delta, driven by human activities, hinders wetland accretion, carbon sequestration, and overall ecosystem stability.
How do genome abnormalities impact mitochondrial homeostasis?
Authors: Kurpa Olha , Amponsah Prince Saforo 
Published: February 2025

Abstract
The genome of eukaryotes encodes thousands of proteins needed to ensure cell health. Hence, an imbalance in the genome has profound consequences for protein homeostasis (proteostasis). The genome and proteome are interlocked in a mutual relationship, which impacts the functions of cellular organelles like mitochondria. However, the underlying mechanisms remain an enigma. Here, we highlight this relationship and outline some open questions to be addressed.
Towards a Data-Driven Organisation: Making Data a Strategic Knowledge Asset in SMEs
Authors: Kling Nico , Haugk Sebastian , Gebauer Heiko 
Published: February 2025

Abstract
Demographic shifts in organisations create an urgent knowledge management challenge: as experienced employees retire, their specialised knowledge must transfer to younger workers. This transition drives small- and medium-sized enterprises (SME) to move from intuitive to data-driven decision-making. We examine how SMEs can leverage data as a strategic knowledge asset during this transformation. Drawing from knowledge-based theory and analysing insights from 200 companies, we develop a practical framework for SMEs’ data-driven evolution. Our research identifies three critical transformation phases: recognising data’s value, building data capabilities, and integrating data into knowledge management. We derive six actionable principles that help SMEs balance structure with adaptability: (1) identifying data’s strategic potential, (2) managing data as a core resource, (3) developing specialised talent, (4) creating efficient coordination mechanisms, (5) nurturing emergent strategies, and (6) implementing flexible data strategies. These principles offer SME managers practical guidance while contributing to academic understanding of data-driven organisations. Our framework particularly helps resource-constrained SMEs navigate their data transformation journey efficiently. Future research should validate these principles quantitatively across different knowledge-intensive sectors.
Endometrial factors and pregnancy loss frequency in recurrent pregnancy loss patients: comparing RT-PCR microbiology, microbial cultures, and immunohistochemistry of endometrium biopsy
Authors: Klimaszyk K. , Wirstlein P. , Bednarek-Rajewska K. , Jankowski M. , Svarre Nielsen H. , Wender Ożegowska E. , Kędzia M. 
Published: February 2025

Abstract
The objective of this study is to investigate the presence of bacteria in endometrial samples from patients with recurrent pregnancy loss (RPL) and explore potential correlations between bacterial presence, chronic endometritis, and previous pregnancy loss history. Endometrial samples from 90 RPL patients were analysed using RT-PCR to detect 10 specific bacterial species. A subgroup of 65 patients underwent additional microbial culture and immunohistochemistry for plasma cell identification. Correlations between bacterial presence, chronic endometritis, and the number of previous pregnancy losses were evaluated. We detected at least one out of 10 chosen bacteria DNA by RT-PCR in 24.4% (22/90) of endometrial samples. Patients with PCR-identified bacteria had a significantly higher number of previous pregnancy losses (median 3 vs 2, p = 0.01). No correlation was observed between bacterial presence and chronic endometritis diagnosis. A significant correlation was found between bacterial detection by PCR and microbial culture (p = 0.03), though culture methods detected fewer positive cases. In RPL patients, detecting DNA from at least one of 10 selected bacterial species by RT-PCR correlates with a higher number of previous pregnancy losses. However, this bacterial presence does not correlate with chronic endometritis diagnosis based on the CD138 immunohistochemistry-identified plasma cell count. These findings suggest a potential role of endometrial bacteria in RPL that may be independent of the classical inflammatory response associated with chronic endometritis.
Anesthetic Considerations for Orthopedic Amputation Surgery
Authors: Howard Abigail , Kolodzie Kerstin 
Published: February 2025

Abstract

Purpose of Review
This review summarizes the anesthetic considerations for amputation for orthopedic indications including trauma, malignancy, infection, or congenital anomalies. Much of the literature has previously focused on amputation for vascular disease.

Recent Findings
Neuraxial anesthesia and peripheral nerve blocks are the most promising modalities to decrease perioperative pain, though it is unclear if they prevent long-term phantom limb pain (PLP). Treatments for PLP aim to disrupt the abnormal signaling along the peripheral and central pathways, including through medications, peripheral nerve stimulators, and surgical therapies.

Summary
Perioperative management of orthopedic amputation patients should involve a multidisciplinary team that focuses on improved pain management, early rehabilitation, and improved patient satisfaction. Additional research is needed to determine the optimal regional anesthesia technique and evaluate its effect on perioperative outcomes.
Theories of institutional change and marine privatisation
Authors: Schlüter Achim , van Assche Kristof , Fall Sidy , Senghor Khadidiatou , Banikoi Hudu , Kane Elimane 
Published: February 2025

Abstract
Privatisation, as a process that assigns more individual property rights, implies in most cases institutional change. Privatisation might occur on the level of society, when formal laws, but often also informal rules are changing, or it might take place on an organisational level when an asset under an open access regime, a cooperative, or a state-owned company is converted into a privately managed entity. From this perspective, it seems obvious that theories of institutional change provide a certain understanding of privatisation processes in the marine realm. Processes of marine privatisation are very heterogeneous in their characteristics: some processes are informal, some take part in the business world, others in the political realm, some are to a certain degree planned, others are emerging and have more evolutionary characteristics, some are characterised by huge power asymmetries others take place under more equal footing. Therefore, this paper interrogates a broad range of theories of institutional change. Our perspective does not proclaim or investigate superiority of one theory above the other, but rather inquires about fit. After elaborating on the theories, clarifying their focus, core concepts and assumptions, the paper illustrates the explanatory powers of the theories by looking at the case of privatisation of space in Saint Louis, Senegal. Due to strong restrictions for Senegalese fishers to fish in Mauritanian waters, the establishment of a marine protected area, and more recently the establishment of a gas field on the doorstep, fishers are confronted with an enclosure of their commons.
Discussion: Utilizing Waste‑Shredded Rubber Pieces for Improved Foundation Stability [Transp. Infrastruct. Geotech. 11(6), 3941–3968]
Authors: Soltani Amin , O’Kelly Brendan C. 
Published: February 2025

Abstract
This communication article presents a discussion of various identified shortcomings in the original research paper by Thapa et al. (the Authors) that was recently published in Transp. Infrastruct. Geotech. 11(6), 3941–3968, 2024. The Authors investigated the application of waste shredded rubber pieces (SRPs) for improving the performance of shallow foundations bearing on a problematic collapsible soil obtained from the Western Uttar Pradesh region of India. They performed laboratory experiments, including Atterberg (consistency) limits, compaction, unconfined compressive strength and undrained direct-shear tests, on the unamended soil (i.e., 0% SRP content) and five soil–SRP blends prepared with gravimetric SRP contents ranging from 1% to 5%. Moreover, the Authors employed finite-element method (FEM) modeling to assess the effects of SRP content on the ultimate bearing capacity (B) and settlement (S) response of an infinite strip footing bearing on the investigated compacted soil–SRP blends. Using the results obtained from the six FEM simulations, the Authors then produced multiple linear regression (MLR) models for predicting the FEM-generated B and S values of the compacted soil amended with 0–5% SRP additive. In this communication article, the Discussers raise several shortcomings of the Authors’ research, including (i) the presented Atterberg limits results are fundamentally compromised by the inclusion of the coarse SRP additive in the test material, and (ii) the validity and applicability of their proposed MLR models for predicting the B and S responses of shallow footings bearing on the SRP-amended soil.
Quantitative Steinitz theorem: a spherical version
Authors: Ivanov Grigory , Naszódi Márton 
Published: February 2025

Abstract
Steinitz’s theorem states that if the origin belongs to the interior of the convex hull of a set

$$Q \subset {\mathbb {R}}^d,$$

Q
⊂

R

d

,

then there are at most 2d points

$$Q^\prime $$

Q
′

of Q whose convex hull contains the origin in the interior. Bárány, Katchalski and Pach gave a quantitative version, whereby the radius of the ball contained in the convex hull of

$$Q^\prime $$

Q
′

is bounded from below. In the present note, we show that a Euclidean result of this kind implies a corresponding spherical version.
Earth recharge model with crossover behaviors: application of piecewise differentiation
Authors: Tloliso Nape , Atangana Abdon 
Published: February 2025

Abstract
The estimation of groundwater recharge is usually done with direct or indirect measurement techniques that are site-specific and derived primarily from flux measurements that due to the flexibility and uncertainty associated with heterogeneous systems has a high margin of error. Fractional derivatives, which are used to reflect the geological heterogeneity and fluid viscoelasticity, may be introduced to solve this challenge. Here, we develop sensitivity analyses to model groundwater recharge in a two-layer (homogeneous upper and highly heterogeneous lower) shallow unconfined aquifer system. The bottom of the model showed a non-Darcian fracture and matrix flow, and associated flow deviation, while the top of the model represented a uniform high-permeability and high-porosity layer, typical for calcite-rich areas. The EARTH model is the governing equation of the system, analytically solved through the use of Laplace and inverse Laplace transforms. A new multi-layer aquifer model for the spatial-parameter, temporal-parameter groundwater flow model established in Earthlab. The model features later flow, gradual layer transitions and appropritate boundary conditions. It also considers evapotranspiration and seasonal recharge, providing a better model for groundwater behavior in heterogeneous aquifer systems. A fractional-order differential equation is proposed to describe recharge dynamics for the homogeneous upper layer and a classical integer-order differential equation for the heterogeneous lower layer with non-Darcy flow. This work applies Caputo and Atangana-Baleanu fractional derivatives to investigate crossover behaviors in the system. The results show unique long-tail exponential growth structures in the homogeneous layer and crossover behaviors at early times that depend on the operator. In contrast, despite the scale invariance property of the Caputo derivative, the Atangana-Baleanu derivative detects alpha-to-alpha crossovers, stressing its ability to reproduce early-time behavior. This study presents a powerful solution for describing groundwater recharge in dual-layered aquifer systems by coupling a fractional differentiation model with the extended Mittag–Leffler law, providing a new insight into understanding heterogeneous and homogeneous formations. This approach may be cross-validated with field data and will provide more evidence for capillary-dominated flow, using fractional derivatives to model subsurface flow.