bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robotic-assisted spine surgery allows for increased pedicle screw sizes while still improving safety as indicated by elevated triggered electromyographic thresholds
Authors: Kanaly Charles W. , Backes Danielle M. , Toossi Nader , Bucklen Brandon 
Published: November 2022

AbstractThe present study used triggered electromyographic (EMG) testing as a tool to determine the safety of pedicle screw placement. In this Institutional Review Board exempt review, data from 151 consecutive patients (100 robotic; 51 non-robotic) who had undergone instrumented spinal fusion surgery of the thoracic, lumbar, or sacral regions were analyzed. The sizes of implanted pedicle screws and EMG threshold data were compared between screws that were placed immediately before and after adoption of the robotic technique. The robotic group had significantly larger screws inserted that were wider (7 ± 0.7 vs 6.5 ± 0.3 mm; p < 0.001) and longer (47.8 ± 6.4 vs 45.7 ± 4.3 mm; p < 0.001). The robotic group also had significantly higher stimulation thresholds (34.0 ± 11.9 vs 30.2 ± 9.8 mA; p = 0.002) of the inserted screws. The robotic group stayed in the hospital postoperatively for fewer days (2.3 ± 1.2 vs 2.9 ± 2 days; p = 0.04), but had longer surgery times (174 ± 37.8 vs 146 ± 41.5 min; p < 0.001). This study demonstrated that the use of navigated, robot-assisted surgery allowed for placement of larger pedicle screws without compromising safety, as determined by pedicle screw stimulation thresholds. Future studies should investigate whether these effects become even stronger in a later cohort after surgeons have more experience with the robotic technique. It should also be evaluated whether the larger screw sizes allowed by the robotic technology actually translate into improved long-term clinical outcomes.
A Case of Multicystic Biliary Hamartoma with a Marked Peribiliary Gland Component Successfully Treated by Purely Laparoscopic Anatomical Liver Resection
Authors: Kai Keita , Ide Takao , Tanaka Tomokazu , Yukimoto Kumpei , Irie Hiroyuki , Noshiro Hirokazu , Aishima Shinichi 
Published: November 2022

Abstract
Background
Multicystic biliary hamartoma (MCBH) is an extremely rare benign liver lesion characterized by a gross well-circumscribed multicystic honeycomb appearance. This report presents a MCBH case with a marked peribiliary gland component which showed unusual histology.

Case Presentation
A 63-year-old Japanese male was admitted to our hospital for a detailed examination of a hepatic cystic lesion, which was originally detected 14 years ago and had slowly enlarged. A preoperative imaging study revealed a well-demarcated multicystic lesion without communication to the biliary tracts. The possible clinical diagnoses were mucinous cystic neoplasm (MCN) or MCBH. The lesion was successfully resected by purely laparoscopic right anterior sectionectomy. The cut surfaces of resected specimens grossly exhibited a well-circumscribed multicystic lesion with a thick septum. Histologically, the cyst wall was covered by cuboidal epithelial cells resembling epithelium of the bile duct while abundant small ducts, which morphologically resembled peribiliary glands, were observed among the fibrous stroma of the thick septum. Although possible pathological diagnosis varied, including intrahepatic cholangiocarcinoma, intraductal papillary neoplasm of the bile duct, biliary adenofibroma, MCN and MCBH, the lesion was finally diagnosed as MCBH with a marked peribiliary gland component.

Conclusions
MCBH can contain abundant peribiliary glands in the fibrous stroma. A pathologist should be careful not to diagnose such peribiliary glands in MCBH as neoplastic glands.
Unequally and Non-linearly Weighted Averaging Operators as a General Homogenization Approach for Phase Field Modeling of Phase Transforming Materials
Authors: von Oertzen V. , Kiefer B. 
Published: November 2022

AbstractThe phase field method has been shown to have tremendous potential to serve as a continuum modeling approach of microstructural evolution mechanisms in many contexts, such as alloy solidification, fracture, and chemo-mechanics. By replacing sharp interfaces between phases with a diffuse representation, additional degrees of freedom, namely order parameters, enter the continuum model, in order to describe the current phase state at each material point. Single-phase properties thus need to be interpolated carefully within diffuse interface regions by applying mixture rules subject to specific, microscopic constraints in an underlying homogenization framework. However, there exists a variety of well-established nonlinear interpolation schemes—especially incorporating symmetric or hyperspherical order parameters—for which it turns out that they cannot consistently be described within conventional homogenization theories. To overcome this problem, an extension toward unequally, non-linearly weighted averaging operators is presented, in which conventional, unweighted homogenization represents a special case. The embedding of Reuss–Sachs, Taylor–Voigt, and rank-one convexification models—extended by nonlinear interpolation—within the proposed framework is demonstrated by identifying necessary constraints on corresponding weighting functions. Since this concept establishes a generalization of conventional homogenization, the following question arises: Could any effective property interpolation within the diffuse interface fit into the proposed framework by choosing appropriate weighting functions, and if so, under which microscopic constraints? To this end, the concepts of macroscopic links and domain relations are introduced and applied for conventional homogenization schemes in phase field modeling. Important, yet often subtle, implications of such theoretical considerations on the prediction of microstructure formation and evolution by means of phase field modeling are the focus of discussion in this contribution.
Carbon capture and storage (CCS): development path based on carbon neutrality and economic policy
Authors: Shen Minghai , Kong Fulin , Tong Lige , Luo Yang , Yin Shaowu , Liu Chuanping , Zhang Peikun , Wang Li , Chu Paul K. , Ding Yulong 
Published: November 2022

AbstractIn order to limit global warming to 2 °C, countries have adopted carbon capture and storage (CCS) technologies to reduce greenhouse gas emission. However, it is currently facing challenges such as controversial investment costs, unclear policies, and reduction of new energy power generation costs. In particular, some CCS projects are at a standstill. To promote the development of CCS projects in different countries, this paper reviews and compares energy conservation and emission reduction policies and different national goals. From a policy perspective, CCS-driven policies are analyzed. Based on this, corresponding policy recommendations are put forward, in order to promote the healthy development of global CCS technology and deal with climate issues more effectively. With less than 10 years away from the short-term goal, promoting the development and application of CCS projects requires scientific research from universities, enterprises and governments in order to attain zero or negative CO2 emission. On the basis of focusing on the development of CCS technology, according to the actual situation of each country, the appropriate application of CCS engineering should focus on the development of science and technology, rather than a unified requirement around the world.
COVID-19 Outbreak Related to PM10, PM2.5, Air Temperature and Relative Humidity in Ahvaz, Iran
Authors: Khaniabadi Yusef Omidi , Sicard Pierre , Dehghan Bahram , Mousavi Hassan , Saeidimehr Saeid , Farsani Mohammad Heidari , Monfared Sadegh Moghimi , Maleki Heydar , Moghadam Hojat , Birgani Pouran Moulaei 
Published: November 2022

AbstractIn this study, we assessed several points related to the incidence of COVID-19 between March 2020 and March 2021 in the Petroleum Hospital of Ahvaz (Iran) by analyzing COVID-19 data from patients referred to the hospital. We found that 57.5% of infected referrals were male, 61.7% of deaths by COVID-19 occurred in subjects over 65 years of age, and only 2.4% of deaths occurred in younger subjects (< 30 years old). Analysis showed that mean PM10 and PM2.5 concentrations were correlated to the incidence of COVID-19 (r = 0.547, P < 0.05, and r = 0.609, P < 0.05, respectively) and positive chest CT scans (r = 0.597, P < 0.05, and r = 0.541, P < 0.05 respectively). We observed that a high daily air temperature (30–51 °C) and a high relative humidity (60–97%) led to a significant reduction in the daily incidence of COVID-19. The highest number of positive chest CT scans were obtained in June 2020 and March 2021 for daily air temperature ranging from 38 °C and 49 °C and 11 °C and 15 °C, respectively. A negative correlation was detected between COVID-19 cases and air temperature (r =  − 0.320, P < 0.05) and relative humidity (r =  − 0.384, P < 0.05). In Ahvaz, a daily air temperature of 10–28 °C and relative humidity of 19–40% are suitable for the spread of coronavirus. The highest correlation with the number of COVID-19 cases was found at lag3 (r = 0.42) and at lag0 with a positive chest CT scan (r = 0.56). For air temperature and relative humidity, the highest correlations were found at day 0 (lag0). During lockdown (22 March to 21 April 2020), a reduction was observed for PM10 (29.6%), PM2.5 (36.9%) and the Air Quality Index (33.3%) when compared to the previous month. During the pandemic period (2020–2021), the annual mean concentrations of PM10 (27.3%) and PM2.5 (17.8%) were reduced compared to the 2015–2019 period.
The particularities of a ballet collection: the Nélida Piñon Collection at Instituto Cervantes Rio de Janeiro
Authors: Paschoa Carlos Alberto Della , Melo Elisete de Sousa 
Published: November 2022

The authors discuss a bibliographical collection focused on ballet, the personal library of the Brazilian writer and academic of Galician descent Nélida Piñon. The academic donated her private library to Instituto Cervantes Rio de Janeiro in 2022.This article is based on a paper presented at 'Challenges of art librarianship: 2020 and beyond'.1
Outflows and disks in post-RGB objects — products of common envelope ejection?
Authors: Sarkar Geetanjali , Sahai Raghvendra 
Published: November 2022

AbstractInteracting binaries within a common envelope, wherein the primary is a red giant are believed to result in a recently identified evolutionary class – the dusty post-RGB stars. Our SED modeling of eight post-RGBs in the LMC indicates the presence of geometrically thick disks with substantial opening angle in addition to the outer shells. We estimated the total dust mass (and gas mass assuming gas-to-dust ratio) in the disks and shells and set constraints on the dust grain compositions and sizes. The only known Galactic object of this class is the Boomerang nebula. Additionally, we present a DUSTY model of the Boomerang that can serve as a template for 2D modeling of the object using RADMC-3D. 2D modeling is essential to dissect the morphology of the spatially-unresolved post-RGBs in the LMC. These models may then be tested with future HST and ALMA imaging, together with JWST spectroscopy of these objects.
The interplay between mass-loss and binarity
Authors: Sana Hugues 
Published: November 2022

AbstractMost stars with birth masses larger than that of our Sun belong to binary or higher order multiple systems. Similarly, most stars have stellar winds. Radiation pressure and multiplicity create outflows of material that remove mass from the primary star and inject it into the interstellar medium or transfer it to a companion. Both have strong impact on the subsequent evolution of the stars, yet they are often studied separately. In this short review, I will sketch part of the landscape of the interplay between stellar winds and binarity. I will present several examples where binarity shapes the stellar outflows, providing new opportunities to understand and measure mass loss properties. Stellar winds spectral signatures often help clearly identifying key stages of stellar evolution. The multiplicity properties of these stages then shed a new light onto evolutionary connections between the different categories of evolved stars.
Latent growth analysis of children’s height growth trajectories
Authors: Wake Senahara Korsa , Zewotir Temesgen , Muluneh Essey Kebede 
Published: November 2022

AbstractCharacterizing and quantifying the trajectories of variables of interest through time in their field of study is of interest to a range of disciplines. The aim of this study was to investigate the growth speed in height of children and its determinants. A total of 3401 males and 3200 females from four low- and middle-income countries with measured height on five occasions from 2002 to 2016 were included in the study. Data were analyzed using a latent growth model. The results of the study reported that children in four low- and middle-income countries exhibited substantial growth inequalities. There was a significant gender difference in change of growth with males had a higher baseline, rate of change, and acceleration in height growth than females. Comparing the component of slopes across countries, the growth change inequalities were observed among children. These inequalities were statistically significant, with the highest rate of change observed in Peru and Vietnam.
Craton Destruction Induced by Drastic Drops in Lithospheric Mantle Viscosity
Authors: Wang Lu , Liu Jia , Xu Qi‐Hu , Xia Qun‐Ke 
Published: November 2022

AbstractThe disruption of the mantle roots of cratons is common after cratonization. Craton destruction, which is characterized by severe lithospheric thinning, extensive thrust and extensional deformation, basin filling, and intense thermal activities, is relatively rare and is generally attributed to intensely reduced viscosity contrasts between the lithospheric mantle root and the underlying asthenosphere. However, the extent of the required viscosity contrast remains unclear. The North China craton (NCC) is a typical example of a partially destroyed craton, with its eastern part experiencing destruction in the Early Cretaceous. In this study, we measured the water content of clinopyroxene phenocrysts in Middle Jurassic lithospheric mantle‐derived, weakly alkaline volcanic rocks from the Shanhaiguan area. Our data and those of previous studies show that the lithospheric mantle in the eastern NCC contained substantial amounts of water (650–2,900 ppm) before craton destruction. In addition, the continuous supply of water by the subducted Paleo‐Pacific slab resulted in a more hydrous lithospheric mantle (up to ca. 9,000 ppm) during the craton destruction. The viscosity contrasts between the lithospheric mantle root and the asthenosphere (with an average viscosity of 3.7 × 1018 Pa s) were 2–8 and 0.3–2 before and during the craton destruction, respectively. Our study indicates that a drastic drop in the lithospheric mantle viscosity, which is controlled by the synergic effects of a high water content and elevated temperature, is required to induce craton destruction.
Global Recharge Data Set Indicates Strengthened Groundwater Connection to Surface Fluxes
Authors: Berghuijs Wouter R. , Luijendijk Elco , Moeck Christian , van der Velde Ype , Allen Scott T. 
Published: November 2022

AbstractGroundwater is an invaluable global resource, but its long‐term viability as a resource for consumption, agriculture, and ecosystems depends on precipitation recharging aquifers. How much precipitation recharges groundwaters varies enormously across Earth's surface, yet recharge rates often remain uncertain. Here we use a global synthesis of field‐estimated recharge across six continents to show that globally recharge first‐order follows a simple function of climatic aridity. We use this relationship to estimate long‐term recharge in energy‐limited systems outside of permafrost regions. Our aridity‐based recharge estimates are consistent with the global field data but, on average, double previous estimates of global models. Our higher recharge estimates are likely caused by preferential groundwater recharge and discharge occurring at grid scales finer than global models. The higher recharge estimates suggest that more groundwater contributes to evapotranspiration and streamflow than previously represented by global hydrological models and global water cycle diagrams.
Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans
Authors: Hassani Nia Fatemeh , Woike Daniel , Bento Isabel , Niebling Stephan , Tibbe Debora , Schulz Kristina , Hirnet Daniela , Skiba Matilda , Hönck Hans-Hinrich , Veith Katharina , Günther Christian , Scholz Tasja , Bierhals Tatjana , Driemeyer Joenna , Bend Renee , Failla Antonio Virgilio , Lohr Christian , Alai Maria Garcia , Kreienkamp Hans-Jürgen 
Published: November 2022

AbstractPostsynaptic scaffold proteins such as Shank, PSD-95, Homer and SAPAP/GKAP family members establish the postsynaptic density of glutamatergic synapses through a dense network of molecular interactions. Mutations in SHANK genes are associated with neurodevelopmental disorders including autism and intellectual disability. However, no SHANK missense mutations have been described which interfere with the key functions of Shank proteins believed to be central for synapse formation, such as GKAP binding via the PDZ domain, or Zn2+-dependent multimerization of the SAM domain. We identify two individuals with a neurodevelopmental disorder carrying de novo missense mutations in SHANK2. The p.G643R variant distorts the binding pocket for GKAP in the Shank2 PDZ domain and prevents interaction with Thr(−2) in the canonical PDZ ligand motif of GKAP. The p.L1800W variant severely delays the kinetics of Zn2+-dependent polymerization of the Shank2-SAM domain. Structural analysis shows that Trp1800 dislodges one histidine crucial for Zn2+ binding. The resulting conformational changes block the stacking of helical polymers of SAM domains into sheets through side-by-side contacts, which is a hallmark of Shank proteins, thereby disrupting the highly cooperative assembly process induced by Zn2+. Both variants reduce the postsynaptic targeting of Shank2 in primary cultured neurons and alter glutamatergic synaptic transmission. Super-resolution microscopy shows that both mutants interfere with the formation of postsynaptic nanoclusters. Our data indicate that both the PDZ- and the SAM-mediated interactions of Shank2 contribute to the compaction of postsynaptic protein complexes into nanoclusters, and that deficiencies in this process interfere with normal brain development in humans.
Analysis of m6A modulator-mediated methylation modification patterns and the tumor microenvironment in lung adenocarcinoma
Authors: Zeng Qing-Cui , Sun Qin , Su Wen-Jie , Li Jia-Cen , Liu Yi-Sha , Zhang Kun , Yang Li-Qing 
Published: November 2022

AbstractLung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer. In the development and progression of LUAD, epigenetic aberration plays a crucial role. However, the function of RNA N6-methyladenosine (m6A) modifications in the LUAD progression is unknown. The m6A regulator modification patterns in 955 LUAD samples were analyzed comprehensively. Patterns were systematically correlated with the tumor microenvironment (TME) cell-infiltration characteristics. Using principal component analysis algorithms, the m6Ascore was generated to quantify m6A modification patterns in individual tumors. Then, their values for predicting prognoses and therapeutic response in LUAD patients were assessed. Three distinct m6A modification patterns in LUAD were identified. Among them, the prognosis of m6Acluster C was the best, while the prognosis of m6Acluster A was the worst. Interestingly, the characterization of TME cell infiltration and biological behavior differed among the three patterns. To evaluate m6A modification patterns within individual tumors, an m6Ascore signature was constructed. The results showed that the high m6Ascore group was associated with a better prognosis; tumor somatic mutations and tumor microenvironment differed significantly between the high- and low- m6Ascore groups. Furthermore, in the cohort with anti-CTLA-4 treatment alone, patients with a high m6Ascore had higher ICI scores, which indicated significant therapeutic advantage and clinical benefits.
Antibacterial efficacy of silver nanoparticles (AgNPs) against metallo-β-lactamase and extended spectrum β-lactamase producing clinically procured isolates of Pseudomonas aeruginosa
Authors: Muddassir Maria , Raza Almas , Munir Sadaf , Basirat Ahmad , Ahmed Muddassir , Butt Mazia Shahid , Dar Omair Arshad , Ahmed Syed Shoaib , Shamim Saba , Naqvi Syed Zeeshan Haider 
Published: November 2022

AbstractResistance to carbapenems is a global threat, especially in developing countries with limited health resources. Prevalence, antibiogram, PCR detection of antibiotic resistance genes, and potency of Silver Nanoparticles (AgNPs) against multidrug-resistant (MDR) Pseudomonas aeruginosa were studied. Kirby-Bauer disc method and PCR were used to study antibiogram and drug resistance genes respectively in 255 isolates of Pseudomonas aeruginosa obtained from a tertiary care hospital. Silver nitrate (AgNO3) precursor salts were reacted with Aspergillus flavus culture filtrate to trigger the extracellular mycosynthesis of AgNPs. Mycosynthesis was first monitored regularly by visible ultraviolet spectroscopy that recorded AgNP peaks of approximately 400–470 nm. Confirmation by Transmission electron micrographs provided confirmation of AgNPs formed within a range of 5–30 nm. Individual and combined antibacterial activity of ten antibiotics and AgNPs was analyzed. Pearson correlation coefficients (r) were calculated for phenotypic and genotypic multidrug resistance. Data were evaluated using SPSS version 20. p-value < 0.05 was considered statistically significant. 61.5% were carbapenemase producers (p < 0.01). The recorded frequency of blaIMP-1, blaSHV, blaVIM, blaOXA, and blaTEM were 13%, 32%, 15%, 21%, and 43%, respectively. The reducing order of antimicrobial activity of antibiotics and AgNPs was piperacillin/tazobactam + AgNPs (31 mm), cefoxitin + AgNPs (30 mm) > amikacin + AgNPs (25 mm) > aztreonam + AgNPs (23 mm) > meropenem + AgNPs (22 mm) > imipenem + AgNPs (20 mm) > gentamycin + AgNPs (17 mm) > ciprofloxacin + AgNPs (16 mm) > cefoperazone/sulbactam + AgNPs (14 mm) ≥ ceftazidime + AgNPs (14 mm). The conjugated effect of AgNPs plus antibiotics showed a 0.15–3.51 (average of 2.09) fold-area augmentation of antimicrobial activity. AgNPs conjugated with antibiotics effectively inhibited MDR Pseudomonas aeruginosa. To the best of our understanding, this is an inaugural report from Punjab Pakistan enlisting co-expression of Metallo-β-lactamases, extended-spectrum β-lactamases, and AmpC-β-lactamase plus activity of antibiotic-AgNPs.