bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of ABCG1 knockout on proteomic composition of HDL in mice on a chow diet and a high‐fat diet
Authors: Wu Yanxiang , Chen Lianfeng , Xie Ziyan , Wang Chenyu , Zhang Jiahao , Yan Xiaowei 
Published: March 2022

AbstractATP‐binding cassette transporter G1 (ABCG1) is a cellular transmembrane protein that transports oxysterol efflux from cells to high‐density lipoprotein (HDL) particles in the plasma. Previous studies have demonstrated that an ABCG1 deficiency exerts an antiatherosclerotic function through the effects of oxysterol accumulation in cells to enhance apoptosis and regulate inflammatory processes. However, whether the deficiency of ABCG1 and the corresponding changes in the efflux of oxysterols could take a series of impacts on the proteomic composition of HDL remains unclear. Here, plasma HDL of ABCG1(−/−) mice and their wild‐type controls on a normal chow diet (NCD) or a high‐fat diet (HFD) were isolated by ultracentrifugation. The proportion of 7‐ketocholesterol and the proteomic composition of samples were comparatively analyzed by LC‐MS/MS. In NCD‐fed mice, lipid metabolism‐related protein (arachidonate 12‐lipoxygenase) and antioxidative protein (pantetheinase) exhibited increased accumulation, and inflammatory response protein (alpha‐1‐antitrypsin) was decreased in accumulation in ABCG1(−/−) mice HDL. In HFD‐fed mice, fewer proteins were detected than that of NCD‐fed mice. The ABCG1(−/−) mice HDL exhibited increased accumulation of lipid metabolism‐related proteins (e.g., carboxylesterase 1C, apolipoprotein (apo)C‐4) and decreased accumulation of alpha‐1‐antitrypsin, as well as significantly reduced proportion of 7‐ketocholesterol. Additionally, positive correlations were found between 7‐ketocholesterol and some essential proteins on HDL, such as alpha‐1‐antitrypsin, apoA‐4, apoB‐100, and serum amyloid A (SAA). These results suggest a detrimental impact of oxysterols on HDL composition, which might affect the antiatherosclerotic properties of HDL.
Predictors of cognitive gains during inpatient rehabilitation for older adults with traumatic brain injury
Authors: Byom Lindsey , Zhao Amy T. , Yang Qing , Oyesanya Tolu , Harris Gabrielle , Cary Michael P. , Bettger Janet Prvu 
Published: March 2022

AbstractIntroductionTraumatic brain injury (TBI) among older adults is increasing and can affect cognition. To effectively meet the rehabilitation needs of older adults, a clearer picture is needed of patient‐, clinical‐, and facility‐level characteristics that affect cognitive recovery during inpatient rehabilitation facility (IRF) stays.ObjectiveTo identify patient, clinical, and facility factors associated with cognitive recovery among older adults with TBI who received IRF care.DesignSecondary data analysis.SettingUniform Data System for Medical Rehabilitation‐participating IRFs in the United States.PatientsPatients were 65 to 99 years of age at IRF admission for TBI. Participants received IRF care between 2002 and 2018 (N = 137,583); 56.3% were male; 84.2% were white; mean age was 78.7 years.Main Outcome MeasureChange in Functional Independence Measure Cognitive Score (FIM‐Cognitive) from IRF admission to discharge, categorized as favorable (FIM‐cognitive score gains ≥3 points) or poor (FIM‐cognitive score gains <3 points) cognitive outcomes.InterventionsNot applicable.ResultsPatients had greater odds of favorable cognitive recovery if they were female (adjusted odds ratio [aOR] 1.05, 95% confidence interval [CI] 1.05–1.08), had higher motor functioning at IRF admission (aOR 1.03, 95% CI 1.03–1.04), longer length of stay (aOR 1.07, 95% CI 1.06–1.07), or received care at a freestanding IRF (vs. hospital rehab unit) (aOR 1.57, 95% CI 1.52–1.61). Patients who were older (aOR 0.99, 95% CI 0.98–0.99), Black (aOR 0.79, 95% CI 0.75–0.83), Hispanic or Latino (aOR 0.97, 95% CI 0.91–1.02), or were part of another racial or ethnic group (aOR 0.85, 95% CI 0.81–0.90) (vs. White), had high‐cost comorbid conditions (aOR 0.71, 95% CI 0.65–0.76), or who had higher cognitive functioning at IRF admission (aOR 0.90, 95% CI 0.90–0.91) had lower odds of favorable cognitive recovery.ConclusionsPatient (age, sex, race, ethnicity), clinical (level of functioning at IRF admission, length of stay) and facility (e.g., freestanding IRF) factors contributed to the cognitive recoveries of older adults during IRF stays.
Optimal input filtering for networked iterative learning control systems with packet dropouts and channel noises in both sides
Authors: Huang Lixun , Sun Lijun , Wang Tao , Zhang Qiuwen , Li Jianyong , Zhang Zhe , Liu Weihua 
Published: March 2022

AbstractThis article is concerned with the convergence performance of wireless networked iterative learning control (ILC) systems with data dropouts and channel noises in both sensor‐to‐controller and controller‐to‐actuator channels. In order to improve the convergence performance of such ILC systems, an optimal input filter is developed at the actuator side to estimate controller updated input with the effect of these network uncertainties. Specifically, a filtering model is constructed only by using the learning process of P‐type controllers and the transmission process of both measured output data and updated input data. On the basis of this model and the orthogonality principle, the filter in the sense of linear minimum variance is designed at the actuator side so that the controller updated input could be estimated in iteration domain. The convergence performance of filtering error covariance matrix is analyzed theoretically. Moreover, because the filter design does not employ plant information, the tracking performance of any plant with P‐type learning controllers can be improved by driving with the filtered input. Simulation results show that the proposed filtering method is effective.
TetraFLEX: Design and kinematic analysis of a novel self‐aligning family of 3T1R parallel manipulators
Authors: Simas Henrique , Di Gregorio Raffaele , Simoni Roberto 
Published: March 2022

AbstractA new family of 3T1R parallel manipulators (PMs) with self‐aligning property, named TetraFLEX, is presented. 3T1R manipulators have many applications in different fields. Moreover, self‐aligning property refers to the presence of passive joints in the PM limbs that are conceived to compensate for possible misalignments between the sliding directions of the actuated prismatic(P)‐pairs. This property allows the fixation of the limbs in different frame geometries. Thus, this advantage broadens the PM applications to field robotics in several scenarios. Here, the position and singularity analyses of the new family of self‐aligning PMs is addressed with a unified approach. The results are that both the direct and the inverse position analyses have simple closed‐form solutions and that wide free‐from‐singularity regions of TetraFLEX PMs' workspace exist. The effectiveness of the technical proposal is also illustrated by discussing their design criteria and kinetostatics performances in a case study.
Selective Hydrogenation of Furfural: Pure Silica Supported Metal Catalysts
Authors: Zhang Min , Yang Jing‐He 
Published: March 2022

AbstractFurfural is a raw material for the preparation of furan derivatives with active chemical properties. Due to its ability to prepare various high value‐added chemicals through oxidation, condensation, hydrogenation, and other reactions, furfural has received extensive attention. The activity of catalyst depends largely on the solvent effect, reaction temperature, metal‐support interaction, metal nanoparticle size, and also depends on the synthesis method of catalyst. In this review, mono‐metal (Cu, Co, Ni, Fe, Zn, Zr, Au, Pt, Pd, etc.) and bimetallic (Cu−, Ni−, Pt− and Pd−, etc.) catalysts supported on mesoporous silica materials for the hydrogenation of furfural to various high value‐added chemicals in gas or liquid phase are highlighted. At the same time, some feasible suggestions are put forward. Mono‐metal catalysts are prone to deactivation (due to carbon deposition and metal sintering), and the addition of a second metal or solvent modification can be used to improve catalyst activity, furfural conversion, and product selectivity.
Silver Nanocatalyst Based Clock Reaction for Multi‐mode Detection of Tetracycline Antibiotics
Authors: Guo Yue , He Haibo , Peng Ruifeng , Guan Mengting , Yan Xiaoxia , Si Xiaojing , Gu Mingzhi , Lei Yunyi , Luo Liqiang 
Published: March 2022

AbstractA silver nanoparticles (AgNPs) catalyzed clock reaction of 4‐nitrophenol (4‐NP) and NaBH4 was fabricated for multi‐mode detection of tetracyclines (TCs). The yellow 4‐NP was reduced to the colorless 4‐aminophenol (4‐AP) using AgNPs as the nanocatalysts, however, it took relatively longer time in the presence of TCs because the AgNPs’ catalytic surface was capped by TCs. The catalytic activity of AgNPs with different concentrations of TCs could be reflected by the visual color and the reaction time of the 4‐NP‐NaBH4 system, which was quantatively measured through chronometric and colorimetric responses. Under the optimal conditions, the detection limits of four TCs were 6.7 to 14.3 nM with the chronometric assay and 28.5 to 42.3 nM with colorimetric assay, respectively. The proposed methods were sensitive to monitor multiple TCs in an economical way, which was successfully applied for detecting of TCs in various environmental water samples.
Performance Analysis of a CompactThree‐Degree‐of‐FreedomOscillatory Actuator for Haptic Device
Authors: Nakamura Ryosuke , Heya Akira , Hirata Katsuhiro 
Published: March 2022

AbstractAsymmetric vibration‐based haptic devices are being developed to apply to various applications such as navigation systems. A mobile‐type three‐dimensional haptic device requires a compact structure. Then, we focused on a three‐degree‐of‐freedom oscillatory actuator (3‐DOFOA). However, conventional 3‐DOFOAs are large in size and weight because they need a large and complicated support mechanism on the outside of the magnetic circuit. Furthermore, they do not satisfy both the requirement of similar force characteristics in each axis and no interference. To address these issues, we propose a novel 3‐DOFOA integrated with a support mechanism that has equal static characteristics in each axis without interference. The proposed structure and operating principle are described in detail in this paper, as well as the force, frequency characteristics, and acceleration responses. As these results, it can be concluded that the proposed actuator is suitable for use as a haptic device. © 2022 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
A Not-For-Profit Economy for a Regenerative Sustainable World
Authors: Hinton Jennifer B. 
Published: March 2022

AbstractThis chapter offers an overview and explanation of how society’s relationship-to-profit plays a significant role in determining social and ecological outcomes. The way in which societies relate to profit plays out in terms of both formal and informal institutions. One formal institution that is key for sustainability is relationship-to-profit, the legal difference between for-profitand not-for-profit forms of business. This chapter explains how relationship-to-profit, as a basic building block of the entire economy, plays a critical role in determining whether the economy drives sustainability crises or allows for meeting everyone’s needs within the ecological limits of the planet. This analysis reveals that the social and ecological crises of the twenty-first century have the same driver: the pursuit and accumulation of private wealth inherent in the for-profit economy. Yet, existent not-for-profit types of business offer a viable way out of this conundrum. In a market composed of not-for-profit businesses, all economic activity and profit would be oriented toward social benefit, keeping financial and material resources circulating to where they are most needed. The financial surplus of business activity would not accumulate in the hands of a few owners, as it does in the for-profit economy.
Effects of ketamine optical isomers, psilocybin, psilocin and norpsilocin on time estimation and cognition in rats
Authors: Popik Piotr , Hogendorf Adam , Bugno Ryszard , Khoo Shaun Yon-Seng , Zajdel Pawel , Malikowska-Racia Natalia , Nikiforuk Agnieszka , Golebiowska Joanna 
Published: March 2022

Abstract
Rationale
Ketamine and psilocybin belong to the rapid-acting antidepressants but they also produce psychotomimetic effects including timing distortion. It is currently debatable whether these are essential for their therapeutic actions. As depressed patients report that the “time is dragging,” we hypothesized that ketamine and psilocybin-like compounds may produce an opposite effect, i.e., time underestimation, purportedly contributing to their therapeutic properties.

Objectives
Timing was tested following administration of (R)- and (S)-ketamine, and psilocybin, psilocin, and norpsilocin in the discrete-trial temporal discrimination task (TDT) in male rats. Timing related to premature responses, and cognitive and unspecific effects of compounds were tested in the 5-choice serial reaction time task (5-CSRTT) in the standard 1-s, and “easier” 2-s stimulus duration conditions, as well as in the vITI variant promoting impulsive responses.

Results
(S)-ketamine (15 but not 3.75 or 7.5 mg/kg) shifted psychometric curve to the right in TDT and reduced premature responses in 5-CSRTT, suggesting expected time underestimation, but it also decreased the accuracy of temporal discrimination and increased response and reward latencies, decreased correct responses, and increased incorrect responses. While (R)-ketamine did not affect timing and produced no unspecific actions, it reduced incorrect responses in TDT and increased accuracy in 5-CSRTT, suggesting pro-cognitive effects. Psilocin and psilocybin produced mainly unspecific effects in both tasks, while norpsilocin showed no effects.

Conclusions
Time underestimation produced by (S)-ketamine could be associated with its antidepressant effects; however, it was accompanied with severe behavioral disruption. We also hypothesize that behavioral disruption produced by psychedelics objectively reflects their psychotomimetic-like actions.
Hydrocarbon-degrading bacteria in Colombia: systematic review
Authors: Rache-Arce Diana Carolina , Machacado-Salas Maryuris , Rosero-García Doris 
Published: March 2022

AbstractPetroleum industry activities worldwide have caused pollution and resulted in environmental degradation. Microorganisms with the potential to reduce pollutant levels by degradation processes have been reported, and bacteria are among such organisms. The first study on bacterial degradation in Colombia was published in 1996. The study isolated bacteria belonging to thePseudomonasgenus from hydrocarbon-polluted sediments. Since then, different reports on degrading bacteria have been published. The objective of this systematic review is to identify and analyze all the studies on hydrocarbon-degrading bacteria performed in Colombia. To accomplish this goal, a literature search was conducted. Inclusion and exclusion criteria were applied, and 37 relevant articles were obtained. We found that 2018 was the year with the largest number of publications in Colombia, and most frequently identified bacterial genera werePseudomonasandBacillus. Some studies showed that the degradation of hydrocarbons is more efficient when bacterial consortia are used rather than pure cultures. This study provides information about bacteria with the potential to degrade hydrocarbons in Colombia, which in turn will be a source of information for future studies in this field.
Explaining multiple patches of aquatic vegetation through linear stability analysis
Authors: Carbonari Costanza , Calvani Giulio , Solari Luca 
Published: March 2022

AbstractAquatic vegetation is ubiquitous in lowland rivers, and it is typically present in the shape of spatial self-organized patches of biomass. In this work, we mathematically define the threshold conditions for the incipient formation of self-organized vegetated patterns in the shape of central or multiple row patches. The analysis is carried out through a linear stability analysis whereby the 2D eco-hydrodynamic model is linearized and the growth rate of small-scale perturbations is evaluated considering a basic state represented by an initially uniformly vegetated and straight channel having a certain aspect ratio and Froude number. Results illustrate that, for given vegetation properties, instability arises when both the Froude number and the aspect ratio are higher than a given threshold; in this case, self-organization occurs, and spatial patterns of patches will develop according to the wavelength associated to the maximum growth rate. Moreover, instability and self-organization take place when the undisturbed vegetation density is lower than upper bound; this suggests that densely vegetated channels, as in the case of rivers populated by invasive species, will not experience the formation of any spatial patterns.
Providing quality of service in omni-path networks
Authors: Cano-Cano Javier , Andújar Francisco J. , Alfaro-Cortés Francisco J. , Sánchez José L. , Mora Gaspar 
Published: March 2022

AbstractNew hierarchical crossbar switch architectures, such as Omni-Path (OPA) and Cray X2, have appeared to improve packet latency, reduce overall cost and increase fault tolerance of the high-performance interconnection networks in supercomputing and data center systems. These and other interconnect technologies (Infiniband or 40/100 Gigabit Ethernet) include support to provide quality of service (QoS) to the applications. In this paper, we show how this QoS support can be enabled to achieve bandwidth and/or latency differentiation in Omni-Path interconnection networks, as a representative case of hierarchical switches. To do that, three different table-based schedulers are used. We include the description of these schedulers and a comparative study by using the results obtained when we evaluate them with Hiperion, a simulation tool that implements an OPA model.
Creep Behavior and Phase Equilibria in Model Precipitate Strengthened Alumina-Forming Austenitic Alloys
Authors: Yamamoto Yukinori , Brady Michael P. , Ren Qing-Qiang , Poplawsky Jonathan D. , Hoelzer David T. , Lance Michael J. 
Published: March 2022

AbstractCreep-rupture behavior and microstructural response in alumina-forming austenitic (AFA) alloys with two different precipitation strengthening mechanisms, “Laves-phase + M23C6 carbide” and “coherent L12 γ′-Ni3(Al,Ti),” were explored as “model” cases of multi-phase, multi-scale heat-resistant AFA alloys for 650–750°C use. These alloys will be used to guide and verify computational alloy design and life-prediction modeling under an on-going eXtremeMAT project through the Office of Fossil Energy and Carbon Management, US Department of Energy. Computational thermodynamics were used to design and predict the amounts of strengthening and deteriorating secondary phases at 750°C. Creep-rupture lives of the alloys tested at 750°C and 100 MPa were in a range of 4000–9000 h, and the microstructure at the gage/grip after creep-rupture testing was compared with isothermally aged alloys for 1500 h, as well as the calculated phases. Detailed microstructure characterization includes phase identification, volume fraction measurement, and compositional analysis, which were correlated with the creep-rupture properties. High-temperature oxidation resistance was also screened and compared with commercial, chromia-forming heat-resistant steels. These model alloys also provide the basis for further design and optimization of next generation AFA alloys with improved creep resistance.
COVID-Krise und Kinderrechte
Authors: Klundt Michael 
Published: March 2022

ZusammenfassungCOVID-19 und die Maßnahmen dagegen stellen auch die Soziale Arbeit besonders in punkto Kinderrechte vor neue und alte Herausforderungen. Massive Verletzungen der UN-Kinderrechtskonvention und ein Anstieg von Armut in kindlichen und jugendlichen Lebenslagen sind zu verzeichnen. Die Art und Weise der Pandemiebekämpfung war und ist nicht alternativlos (gewesen). Der Beitrag hebt hervor, dass die Kinderpolitik der Regierung über weite Strecken von Instrumentalisierung und Kapital-Konformismus, statt von Kinder-Gerechtigkeit gekennzeichnet war und ist. Das muss sich völkerrechts- und grundgesetzgemäß dringend ändern, indem der Kindeswohlvorrang sowie die Kinderrechte auf Schutz, Förderung und Beteiligung (endlich wieder) umgesetzt werden.
Tensions and coalitions: A new trade agreement affects the policy space for nutrition in Vietnam
Authors: Harris Jody , Hrynick Tabitha , Thien Mai Thi My , Huynh Tuyen , Huynh Phuong , Nguyen Phuong , Thow Anne-Marie 
Published: March 2022

AbstractGlobal trade has shaped food systems over centuries, but modern trade agreements are hastening these changes and making them more complex, with implications for public health and nutrition transition. This study aimed to understand the impact of the 2018 Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CPTPP) on the policy space for public health nutrition in Vietnam. We conducted comparative document review and key informant interviews, and our analysis drew on a framework of policy space and the theory of advocacy coalitions. We identified 10 CPTPP sections with potential public health nutrition implications; and 50 Vietnamese policies relevant to nutrition having one or more tensions with one or more CPTPP sections. A majority of policy tensions were in sections of the CPTPP relating to technical barriers to trade and government procurement; most tensions related to protecting policy-making from vested interests. Different groups of policy actors hold different beliefs and interests on these issues, and therefore promote different framings and policy approaches. We identified two advocacy coalitions working very separately on issues affecting nutrition policy space: a trade coalition holding the policy position that free trade improves nutrition by default; and a nutrition coalition holding the policy position that nutrition should be explicitly considered in trade policy. The policy space for nutrition in Vietnam has important potential constraints through written policy, and the trade and nutrition coalitions will need to interact more regularly and constructively in order to foresee where these tensions will arise in practice, and create plans for their mitigation. This study adds to global evidence of free trade agreement impacts on nutrition policy space, and we extend previous work by explaining these actor groupings in the policy space through the theory of advocacy coalitions.
Evaluation of Industry 4.0 Applications in Production
Authors: Joppen Robert , Kühn Arno , Förster Magdalena , Dumitrescu Roman 
Published: March 2022

AbstractIndustry 4.0 promises many potentials in production. Examples are a data-driven optimization of production processes of individual machines, driverless transport systems, and assistance systems. Nevertheless, companies are still hesitant to invest in Industry 4.0 applications. Studies show that one of the main reasons for that is the unclear economic benefit. In this work, we present a systematic approach for the evaluation of Industry 4.0 applications in production. The main goal of the systematic is to create transparency over the evaluation process of an investment in an Industry 4.0 application in production. The evaluation of a concrete technical solution in an existing production system is supported. As a theoretical foundation, a characterization of investments in Industry 4.0 applications is given. From that, a procedure model is derived. It puts the activities to be carried out, the tools to be used and results in a temporal context. The application of the systematic is shown on the basis of an application example.