bluuebunny/crossref_metadata_2025_split huggingface dataset:
Idarubicin‐Loaded DEB‐TACE plus Lenvatinib versus Lenvatinib for patients with advanced hepatocellular carcinoma: A propensity score‐matching analysis
Authors: Fan Wenzhe , Zhu Bowen , Yue Shufan , Zheng Xinlin , Zou Xinhua , Li Fuliang , Qiao Liangliang , Wu Yanqin , Xue Miao , Wang Hongyu , Tang Yiyang , Li Jiaping 
Published: June 2022

AbstractAimsTo investigate the efficacy and safety of lenvatinib and idarubicin‐loaded drug‐eluting beads transarterial chemoembolization (IDADEB‐TACE) in primary advanced hepatocellular carcinoma (HCC).MethodsThis retrospective study included patients with primary advanced HCC who received either lenvatinib monotherapy or lenvatinib plus IDADEB‐TACE as first‐line treatment from September 2019 to September 2020 at three institutes. Overall survival (OS), time to progression (TTP), objective response rate (ORR), and adverse events were compared. Propensity score‐matching was used to reduce the influence of confounding factors on the outcomes.ResultsThe study reviewed 118 patients who received lenvatinib plus IDADEB‐TACE (LIDA group) and 182 who received lenvatinib alone (LEN group). After propensity score‐matching, 78 pairs of patients remained. Compared to patients in the LEN group, those in the LIDA group had better post‐treatment ORR (57.7% vs. 25.6%, p < 0.001, respectively), median OS and TTP (15.7 vs. 11.3 months, hazard ratio [HR] = 0.50, p < 0.001; 8.0 vs. 5.0 months, HR = 0.60, p = 0.003, respectively), 6‐ and 12‐month OS rates (88.5% vs. 71.4%; 67.6% vs. 43.4%, respectively), and progression‐free rates at 6 and 12 months (60.3% vs. 42.3%; 21.1% vs. 10.3%, respectively). Vascular invasion, α‐fetoprotein level, and treatment type were independent OS predictors, and vascular invasion and treatment type were independent TTP predictors. Incidences of nausea/vomiting, fever, abdominal pain, and increased ALT/AST were higher in the LIDA group than in the LEN group.ConclusionsLenvatinib plus IDADEB‐TACE is well‐tolerated and more effective than lenvatinib monotherapy in patients with advanced HCC.
Acute post‐infection cerebellar ataxia following SARS‐CoV‐2 infection: A case report
Authors: Salari Mehri , Hojjati Pour Fatemeh , Zaker Harofteh Bahareh , Etemadifar Masoud 
Published: June 2022

AbstractAPCA is characterized as a sudden loss of coordination of muscle movements due to an infection and is the most frequent form of acute cerebellar ataxia (ACA), a common neurological disease in children. We attempt to underline that acute post‐infectious cerebellar ataxia (APCA) can be a post‐COVID complication in children.
Molecular modifications, biological activities, and applications of chitosan and derivatives: A recent update
Authors: Lima Rita , Fernandes Carla , Pinto Madalena M. M. 
Published: June 2022

AbstractPolysaccharides arouse great interest due to their structure and unique properties, such as biocompatibility, biodegradability, and absence of toxicity. Polysaccharides from marine sources are particularly useful due to the wide variety of applications and biological activities. Chitosan, a deacetylated derivative of chitin, is an example of an interesting bioactive marine‐derived polysaccharide. Moreover, a wide variety of chemical modifications and conjugation of chitosan with other bioactive molecules are responsible for improvements in physicochemical properties and biological activities, expanding the range of applications. An overview of the synthetic approaches for preparing chitosan, chitosan derivatives, and conjugates is described and discussed. A recent update of the biological activities and applications in different research fields, mainly focused on the last 5 years, is presented, highlighting current trends.
Markovnikov‐Selective Hydroboration of Aryl Alkenes Enabled by a Simple Nickel Salt
Authors: Liu Tianfen , Li Chuhan , Bai Jiahui , Zhang Panke , Guo Yinlong , Wang Xiaoming 
Published: June 2022

Comprehensive SummaryThe sustainable development of synthetic reactions catalyzed by earth‐abundant metals is one of the principal goals in homogeneous catalysis. However, so far most of the protocols are still plagued by sophisticated ligands, hazardous activators, high catalyst loading (1—10 mol%) and/or multistep synthesis of the metal complexes in the process development. Consequently, the development of earth‐abundant metal catalysts with high activity from commercially available metal salts is highly desirable for practical utilization of base metal catalyzed synthetic methodology. Herein, we report the catalyst generated in situ from a mixture of catalytic amounts of Ni(acac)2 (as low as 0.005 mol%) and CsF, which is found highly active for Markovnikov‐selective hydroboration of vinylarenes, including 1,1‐disubstituted vinylarenes and internal olefins, affording a wide range of secondary and tertiary alkyl boronates in excellent yields. Mechanistic experiments indicate that the key to the success of this catalysis is the use of CsF, which in combination with pinacolborane acts as an effective activator for Ni(acac)2, probably generating metastable Ni nanoparticles in situ that demonstrate high activity in the catalytic hydroboration (TON up to 18800).
Comparing clinical and nonclinical cancer patient navigators: A national study in the United States
Authors: Wells Kristen J. , Wightman Patrick , Cobian Aguilar Rosa , Dwyer Andrea J. , Garcia‐Alcaraz Cristian , Saavedra Ferrer Elba L. , Mohan Prashanthinie , Fleisher Linda , Franklin Elizabeth F. , Valverde Patricia A. , Calhoun Elizabeth ,   the National Navigation Roundtable Evidence‐Based Task Group
Published: June 2022

BACKGROUNDA nationwide survey was conducted to examine differences between clinical and nonclinical oncology navigators in their service provision, engagement in the cancer care continuum, personal characteristics, and program characteristics.METHODSUsing convenience sampling, 527 oncology navigators participated and completed an online survey. Descriptive statistics, χ2 statistics, and t tests were used to compare nonclinical (eg, community health worker) and clinical (eg, nurse navigators) navigators on the provision of various navigation services, personal characteristics, engagement in the cancer care continuum, and program characteristics.RESULTSMost participants were clinical navigators (76.1%). Compared to nonclinical navigators, clinical navigators were more likely to have a bachelor's degree or higher (88.6% vs 69.6%, P < .001), be funded by operational budgets (84.4% vs 35.7%, P < .001), and less likely to work at a community‐based organization or nonprofit (2.0% vs 36.5%, P < .001). Clinical navigators were more likely to perform basic navigation (P < .001), care coordination (P < .001), treatment support (P < .001), and clinical trial/peer support (P = .005). Clinical navigators were more likely to engage in treatment (P < .001), end‐of‐life (P < .001), and palliative care (P = .001) navigation.CONCLUSIONSThere is growing indication that clinical and nonclinical oncology navigators perform different functions and work in different settings. Nonclinical navigators may be more likely to face job insecurity because they work in nonprofit organizations and are primarily funded by grants.
Solidifying roles, responsibilities, and the process of navigation across the continuum of cancer care: The Professional Oncology Navigation Task Force
Authors: Franklin Elizabeth F. , Dean Monica S. , Johnston Danelle M. , Nevidjon Brenda M. , Burke Susie L. , Simms Booth Lisa M. 
Published: June 2022

Since its founding in 1990, the profession of oncology navigation has grown and evolved. Although core concepts serve as a unifying thread throughout the profession, there has not been formal agreement on standardization of definitions, scopes, and roles for the various types of navigators. This has created challenges for sustainability, including reimbursement for navigation services. Emerging from the Biden Cancer Initiative's patient navigation working group, the Professional Oncology Navigation Task Force was created to serve as the voice of professional oncology organizations with an ultimate goal of solidifying definitions, scopes, and roles of navigators across the care continuum. Task group members are committed to cross‐disciplinary partnership (including nursing, social work, and nonclinically licensed navigation). As the Task Force worked to define, refine, and disseminate professional standards (with input from the navigation community), the work done by the National Navigation Roundtable was vital to our evolving understanding of the profession. This article outlines the importance of that partnership and highlights the relevant findings of each article in this supplement of Cancer to the standardization work.LAY SUMMARY

Within the profession of oncology navigation, definitions, scopes, and roles of navigators have not been solidified.
Standardization of the profession is critical to allow for continued growth and evolution as well as policy direction.
This article introduces the work of the Professional Oncology Navigation Task Force, which created the Oncology Navigation Standards of Professional Practice with input from professional leaders and community stakeholders.
The article also links the work of the National Navigation Roundtable and the critical need to coordinate and amplify efforts across groups.
Reciprocal and Non‐reciprocal Chiroptical Features in Thin Films of Organic Dyes
Authors: Albano Gianluigi , Pescitelli Gennaro , Di Bari Lorenzo 
Published: June 2022

AbstractThe study of chiroptical properties in thin films of chiral organic π‐conjugated dyes is more complex than isotropic solutions, due to the interference of macroscopic anisotropies often present in the solid state. The experimental circularly polarized (CP) absorption (electronic circular dichroism, ECD) and CP emission (circularly polarized luminescence, CPL) of a thin film can be expressed as the sum of several terms, some of which are non‐reciprocal upon film flipping. In this review, we shall discuss the fundamental theoretical concepts about reciprocal and non‐reciprocal chiroptical features in thin films of organic dyes, describing their correlation with the solid‐state structural organization and suggesting a practical toolbox to quantify their relative weight on an experimental ECD or CPL spectrum. Moreover, we shall also take into account the literature on thin films of organic π‐conjugated dyes showing strong non‐reciprocal CP absorption and/or CP emission, due to their potential high interest in the flourishing field of chiral photonics and electronics.
VCSNet: V‐fused color saliency net
Authors: Xu Binjing , Wu Qiong , Qin Hong , Liu Zhiyuan , Shi Lin , Li Shuang 
Published: June 2022

SummaryImage salient region detection methods, which can detect and extract interesting regions in pictures, have been a hot research direction in recent years. Most of current salient region detection algorithms and corresponding training datasets originated from general visual attention processes and primarily reflected attention to object shape in pictures. While color vision provided more useful information in vision systems, the color effect of visual attention should be and must be considered. First, we collected cue data of painting pictures from several observers using eye‐track recording technology when observers were asked to pay attention to color information of various paintings. Second, we constructed a color attention dataset, color saliency dataset (CSD), from the cue data and pictures. Thirdly, we designed a V‐fused color saliency net (VCSNet) model which included three modules: a color information fusion module, a prediction module, and an optimization module and trained the model using the CSD. Finally, we compared our method with previous algorithms on the CSD, and results showed that our method outperformed the previous algorithms in color saliency detection with MAE of 0.057 and Fmax of 0.265. We open source part of the self‐created dataset:https://github.com/InfiniteEM/ColorSaliencyDataSet.
Combining xenia, male sterility, and synchronous pollination to improve maize grain yield and market value
Authors: Westgate Mark , Halbach Rachel , Lauer Mike , VanDeWoestyne Bradley 
Published: June 2022

AbstractXenia (pollination of florets with genetically unrelated pollen), male sterility (removal of fertile pollen), and synchronous pollination (application of pollen when all silks are present) are well‐documented processes that influence kernel formation and development in maize. There also have been numerous reports in which xenia and male sterility were combined in an attempt to increase kernel number, kernel weight, and/or grain yield. We present an analysis of published literature exploring impacts of xenia resulting from cross‐pollination, male sterility, and synchronous pollination applied individually or in combination. Although synchronous pollination has had the most consistent and positive impact on seed formation, to our knowledge there are no reports combining all three effectors together. Recently developed technology to collect, preserve, and apply large volumes of maize pollen has provided the opportunity to evaluate the cumulative and potentially synergistic effects of synchronous pollination, xenia, and male sterility applied together on maize hybrids. We present the results of a field trial combining all three effectors in maize; this approach increased kernels per ear, kernel oil concentration, and grain yield per hectare. The results suggest synchronous pollination is essential to enable the greatest number of kernels to develop successfully. Male sterility supports kernel formation by providing greater assimilate supply per kernel, and xenia increases sink strength to attract the additional assimilates. The positive response and economic return when these effectors are applied in combination provides a novel opportunity for grain producers to manage kernel formation and composition proactively using pollen to deliver the trait of choice.
A compressible image encryption method based on nondegenerate hyperchaotic system and its implementation on ZYNQ
Authors: Yu Wenxin , Zhou Zuanbo 
Published: June 2022

AbstractDigital image plays an important role of information carrier with the rapid development of information technology. In this paper, a compressible image encryption method based on nondegenerate hyperchaos is proposed. Firstly, a nondegenerate hyperchaotic system based on the nonlinear feedback controller is designed, and its dynamic characteristic is analyzed. The image information is compressed by integer discrete cosine transform (DCT). Then the image encryption algorithm is proposed by using the pseudo‐random sequence generated by hyperchaotic system. Finally, the proposed scheme is realized by using ZYNQ development platform. The security of proposed scheme is enhanced by the nondegenerate hyperchaotic system, and the data volume for encryption algorithm is reduced by DCT preprocessing without affecting the image visual quality. The hardware implementation based on ZYNQ platform shows the feasibility of the proposed scheme. Through the security analysis of the experimental results, it is verified that the image can be well encrypted by the proposed method with great performance.
Response of riparian vegetation to short‐ and long‐term hydrologic variation
Authors: Friedman Jonathan M. , Eurich Abigail M. , Auble Gregor T. , Scott Michael L. , Shafroth Patrick B. , Gibson Polly P. 
Published: June 2022

AbstractIncreasing demand for river water now conflicts with an increasing desire to maintain riparian ecosystems. Efficiently managing river flows for riparian vegetation requires an understanding of the time scale of flow effects, but this information is limited by the absence of long‐term studies of vegetation change in response to flow variation. To investigate the influence of short‐ and long‐term flow variability and dam operation on riparian vegetation, we determined the occurrence of 107 plant species in 133 permanent plots of known inundating discharge along the Gunnison River in Colorado on five different occasions between 1990 and 2013. Individual species moved up and down the gradient of inundating discharge coincident with increases and decreases in mean annual flow, and the correlations between flow and species occurrence were strongest when flows were weighted by time before vegetation sampling with a median half‐life of 1.5 years. Some tall, rhizomatous, perennial species, however, responded to flows on a longer time scale. Logistic regression of species occurrence showed a significant relation with inundation duration for 70 out of 107 species. Plot species richness and total vegetative cover decreased in association with desiccation at low inundation durations and with fluvial disturbance at high inundation durations. Within‐plot similarity in species occurrence between years decreased strongly with increasing inundation duration. Moderate inundation durations were dominated by tall, rhizomatous, perennial herbs, including invasivePhalaris arundinacea(reed canary grass). Over the 23‐year study period, species richness declined, and the proportion of rhizomatous perennials increased, consistent with the hypothesis that decreases in flow peaks and increases in low flows caused by flow regulation have decreased establishment opportunities for disturbance‐dependent species. In summary, annual‐scale changes in vegetation were strongly influenced by flow variation, and decadal‐scale changes were influenced by decreases in fluvial disturbance from upstream flow regulation beginning decades prior to the onset of this study.
On the link between tree size and ecosystem carbon sequestration capacity across continental forests
Authors: Zhao Meifang , Sun Mengde , Xiong Tao , Tian Shihong , Liu Shuguang 
Published: June 2022

AbstractThe asymptotic height (Hmax) and the size‐scaling exponent (β), proxies of tree size and important forest architectural parameters of the relationships between height and tree diameter of forests, play important roles in the carbon (C) stocks and fluxes of forest ecosystems. However, the patterns and drivers of these values in continental China are not well known. Based on a national forest database of China, we explored the geographic patterns and ecological drivers of Hmax and β and their dynamic relationships with the C sequestration capabilities of the studied ecosystems, including the C stock and allocation, net ecosystem productivity (NEP), and mean ecosystem C turnover time. At the ecosystem scale, the Hmax values ranged from 10.37 to 37.07 m, with a mean value of 25.41 m, showing a decreasing trend with increasing latitude. However, β ranged from 0.598 to 0.73, with a mean value of 0.66, showing an increasing trend with latitude. The spatial patterns of the forest Hmax and β at the national scale were largely controlled by the mean annual temperature, mean annual precipitation, and forest age. These patterns were verified using biomass and forest C sequestration data, showing that the total vegetation C stock as a whole, in aboveground or belowground components, was significantly and positively correlated with Hmax (p < 0.05), revealing apparent “faster first, slower later” increasing trends with Hmax (R2 = 0.759, 0.821, and 0.527, respectively). In addition, for forest >20 m, NEP showed a significant strong negative correlation with Hmax (by −0.967% per 1 m of Hmax, R2 = 0.504, p < 0.05), and a 10‐m increase in Hmax resulted in a decrease in mean ecosystem C turnover time by 16.9% (7.43 years). Taller forests might indeed be expected to have higher autotrophic respiration consumption rates but lower mean ecosystem C turnover time and NEP values than shorter forests. The discovery that community‐level asymptotic height could be used as a comparative predictor of ecosystem C sequestration capacity and its difference among forest biomes underpins the fundamentals of ecological theories and modeling, which has important implications for forest restoration, policy, and management.
Silence: A predicament for feminist anthropology and social innovation
Authors: Aithamon Marielle 
Published: June 2022

AbstractThis article aims to describe how contemporary societies dominated by racial capitalism and heteropatriarchy view and treat silence as an emptiness to be avoided. Without denying the importance of breaking from the silence of oppression, I argue that the dialectic between norms and silences is at the foundation of sociocultural life. Moreover, silence in feminist theory can be understood as a form of décrochage (lit. “unhooking”) from hegemonic norms, thus opening spaces of doubt and questioning (or spaces of vraisemblance). Dwelling in these spaces, which I believe is the predicament of feminist anthropology, allows us to craft the sociocultural, artistic, and theoretical tools to engage in a state of becoming and emancipation.
Patients' knowledge and concerns about using the implantable cardioverter defibrillator for the primary prevention of sudden cardiac death and its correlates: A cross‐sectional study
Authors: Zakeri Mohammad A. , Sedri Nadia , Bazmandegan Golamreza , Zakeri Maryam , Safariyan Mohammad , Dehghan Mahlagha 
Published: June 2022

AbstractBackground and AimsSudden cardiac death (SCD) is one of the most common causes of mortality in heart failure (HF) patients with reduced ejection fraction. Patients have concerns about the disease and use the implantable cardioverter defibrillator (ICD) to reduce the effects of HF disease. The current study aims to evaluate the barriers and factors affecting the implantation of the ICD for primary prevention.MethodsOne hundred‐forty‐seven patients with HF were studied in public hospitals in southern Iran by using a cross‐sectional design from April 2018 to June 2019. Demographic, researcher‐made questionnaire, World Health Organization Quality of life‐BREF (WHOQOL‐BREF), general self‐efficacy questionnaires, and Multidimensional Scale of Perceived Social Support (MSPSS) were measured for investigating the barriers and impact factors in patent HF.ResultsMost participants were male (56.5%), married (88.4%), illiterate (54.1%), and unemployed (72.6%). 62.6% (n = 92) of the participants did not know about HF and ICD. The total score of patients' concerns about using ICD was 47.11 ± 11.26, which showed a moderate level. The scores of knowledge about HF and ICD had a significant positive poor correlation with self‐efficacy, perceived social support and QoL. Also, the score of concerns about the ICD had a significant negative poor correlation with perceived social support.ConclusionUnderstanding HF patients' issues and obstacles can help us prevent sudden death. Doctors' advice has a significant impact on patients' acceptance. Poor knowledge is the most important reason for nonparticipation. Intervention is necessary to inform patients to understand the advantages and disadvantages.
Maternal depressive symptoms and early childhood temperament before and during the COVID‐19 pandemic in the United Kingdom
Authors: Fiske Abigail , Scerif Gaia , Holmboe Karla 
Published: June 2022

AbstractThe COVID‐19 pandemic is an unexpected and major global event, with the potential to have many and varied impacts on child development. However, the implications of the pandemic for maternal depressive symptoms, early childhood temperament dimensions, and their associations, remain largely unknown. To investigate this, questionnaires were completed by mothers (N = 175) before and during the pandemic when their child was 10‐ and 16‐months old (Study 1), and by an extended group of mothers with young children (6–48 months; 66 additional mothers) during the first and second national lockdowns in the United Kingdom in 2020 (Study 2). Results indicated that while maternal pandemic‐related stress decreased over the first 6 months of the pandemic, there was an increase in mothers who reported feeling some level of pandemic‐specific depression. Despite this, we did not observe an increase in the severity of global maternal depressive symptoms, or any negative impact of the pandemic on the development of temperament in infancy and early childhood.