bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a calculator to predict the pathological nature of colorectal tumors
Authors: Wang yadan , Huang Boyang , Wu Jing , Guo Chunmei , wang canghai , su hui , liu hong , Wang Miaomiao , wang jing , Li Li , Ding pengpeng , Meng Mingming 
Published: August 2022

Abstract
Background and Aims
: No single endoscopic feature can reliably predict the pathological nature of colorectal tumors (CRTs). We aimed to establish and validate a simple online calculator to predict the pathological nature of CRTs based on white-light endoscopy.
Methods
This is a single-center study. During identification stage, 530 consecutive patients with CRTs were enrolled from January 2015 to December 2021 as the derivation group. Logistic regression analysis was performed. A novel online calculator to predict the pathological nature of CRTs based on white-light image was established and verified internally. During validation stage, two series of 110 images obtained using white-light endoscopy were distributed to 10 endoscopists (five highly-experienced endoscopists (HEEs) and five less-experienced endoscopists (LEEs) for external validation, before and after systematic training.
Results
A total of 750 patients were included, with an average age of 63.6 ± 10.4 year-old. Early colorectal cancer (ECRC) was detected in 351 (46.8%) patients. Tumor size, left semicolon, rectum, acanthosis, depression and an uneven surface were independent risk factors for ECRC. The C-index of ECRC calculator prediction model was 0.906 (p = 0.225, Hosmer–Lemeshow test). For the LEEs, significant improvement was made in the sensitivity, specificity and accuracy (57.6% versus 75.5%; 72.3% versus 82.4%; 64.2% versus 80.2%; p < 0.05), respectively, after the training with ECRC online calculator prediction model.
Conclusion
A novel online calculator including tumor size, location, acanthosis, depression, and uneven surface can accurately predict the pathological nature of ECRC.
Northern Hemisphere ice sheet expansion intensified Asian aridification and the winter monsoon across the mid-Pleistocene transition
Authors: Ao Hong , Rohling Eelco J , Li Xinzhou , Song Yougui , Roberts Andrew , Han Yongming , Poulsen Christopher , Jonell Tara , Liebrand Diederik , Sun Qiang , Li Xinxia , Qiang Xiaoke , Zhang Peng , Dekkers Mark 
Published: August 2022

Abstract
The mid-Pleistocene transition (MPT) from ~ 1.25 to ~ 0.6 million years ago (Ma) marked a major shift in periodicity of Earth’s climate variability from dominantly ~ 40- to ~ 100-thousand years (kyr) without a concomitant shift in orbital forcing. Here we advance understanding of Asian climate dynamics associated with two glacial extreme loess coarsening events that are recorded across the Chinese Loess Plateau (CLP) at the onset and middle of the MPT. This is based on a combination of new and existing millennial-resolution grain size and magnetic susceptibility records for the last 1.6 million years from the CLP and general circulation model simulations, viewed within a global palaeoclimatological context. We find that the two extreme glacial events reflect exceptionally enhanced Asian aridification and winter monsoon activity. They occurred at times of notable Northern Hemisphere glacial ice sheet expansion, when the ~ 100-kyr glacial cyclicity initiated and intensified at marine isotope stages 38 and 22 (~ 1.25 and ~ 0.9 Ma), respectively. Our integration of palaeoclimate data and climate model simulations indicates that these anomalously cold, dry, and windy Asian glacials were driven by amplified, non-linear regional threshold responses to phases of Northern Hemisphere ice sheet expansion.
Genetic changes in F1 hybrids of the genetically divergent Solanum L., Solanum melongena L. and Solanum aethiopicum L.
Authors: Yu Ning , Gan Guiyun , Li Dandan , Li Weiliu , Jiang Yaqin , Yang Qihong , Wang Peng , Li Wenjia , Wang Yikui 
Published: August 2022

Abstract
Distant hybridization constitutes an important process in plant evolution. Outbreeding of Solanum plants can produce hybrid progeny with heterobeltiosis in terms of growth, development, and resistance. In this study, the genomic characteristics and genetic variation of reciprocal cross F1 hybrids of strains 177 (Solanum melongena L.) and Y11 (Solanum aethiopicum L.) were quantified to analyze the relationship between heterosis and genomic characteristics. While no significant phenotypic differences existed between the F1 hybrids, their phenotypes were closer to those of the Y11 parent. Using whole-genome resequencing, large numbers of single-nucleotide polymorphisms, insertion or deletions, structural variations, and copy number variation (CNV) were found. The variation rate of the Y11 parent was the highest, while those of the F1 hybrids were similar to each other but closer to Y11. These results reflect the fact that the genome of the heterozygous progenies was stable at the chromosome level; nevertheless, a lot of variation sites were produced, which may underlie the increased phenotypic diversities compared to that found in the cultivated parent plants. Mining and functional annotation of variant genes with different variant types revealed that the highest number of variant genes were caused by CNVs. Moreover, the variant genes were significantly enriched in pathways associated with glucose metabolism, protein synthesis, and phytohormone signaling, indicating that CNVs may be responsible for the heterosis observed in the progeny of outbred crosses. These data can provide a reference for future heterosis research, molecular marker development, genetic engineering, high-density linkage map construction, and genome-wide association analysis.
Relationship between the expression levels of CD4+T cells, IL-6, IL-8 and IL-33 in liver of biliary atresia and postoperative cholangitis, operative age and jaundice clearance
Authors: Zhang Kaizhi , Cheng Yutong , Zheng Zebing , Tang Chengyan , Zhu Daiwei , Xia Xingrong , Huang Lu , Du Qing , Liu Yuanmei , Jin Zhu 
Published: August 2022

Abstract
Objective: To investigate the expression levels of CD4+T cells, IL-6, IL-8,and IL-33 in liver tissue of BA, and the relationship with postoperative cholangitis, operative age and early jaundice clearance.Methods: 45 cases of jaundice treated in hospital from June 2018 to May 2020 were analyzed retrospectively. The expression and distribution of these factors were detected by HE staining and immunohistochemistry, the total bilirubin level and the incidence of cholangitis were recorded, and the relationship between liver inflammation level and the postoperative incidence of cholangitis, age of operation and early jaundice clearance were compared.Results: Immunohistochemistry showed that the expression of CD4+T cells, IL-6, IL-8 and IL-33 in BA group were higher than those in CBD group. ROC curve analysis showed the AUC of CD4+T cells, IL-6 and IL-8 were 0.869, 0.886 and 0.838, respectively. The expression level of CD4+T cells was negatively correlated with the decline rate of TBIL 3 months postoperatively, and the expressions of IL-8 and IL-33 were negatively correlated with the decline rate of TBIL 1 week postoperatively. Conclusion: The high expression of CD4+T cells, IL-6, IL-8 and IL-33 in the BA liver tissue may lead to cholangitis and can be used as a predictor of early jaundice clearance. The degree of liver inflammation infiltration had nothing to do with the age of operation and is not a risk factor for postoperative cholangitis.
Immune-modulating Effects of Mycobacteria
Authors: Gavin Igor , Rosli Filbert , Gillis Bruce S. 
Published: August 2022

Abstract
Background:Several species of Mycobacterium have been identified as having the ability to modulate immune responses, even as heat-killed preparations. Our goal was to identify mycobacteria that could potentially act in a safe and non-toxic immune-modulating effect by promoting the production of specific chemokine and cytokine responses with a potential application for impacting the microbiome. We relied on the following Mycobacterium strains: M. smegmatis, M. agri, M. phlei, M. tokaiense, M. brumae, M. aurum, and M. obuense. Results:M. smegmatis and M. agri were the most effective in inducing immune responses in cultured peripheral blood mononuclear cells (PBMC) manifested by extracellular productions of the cytokine IL-6, as well as the chemokines IL-8, MIP-1α and MIP-1β. Correlation analyses and immune challenges to the bacterial mixtures showed that while cytokine and chemokine responses to M. smegmatis and M. agri were similar, they were different from responses to either B. subtilis or phytohemagglutinin (PHA) resulting in distinct patterns of extracellular cytokine and chemokine productions. Our results suggest that Mycobacterium strains and B. subtilis activated distinct immune response pathways and have different effects on the immune system.Conclusions:We identified several Mycobacterium species as well as B. subtilis as the most efficient immune-modulating agents. Distinct immunomodulatory properties of multiple species may have potential implications for immunotherapy of cancer as well as treatments of various immune-deficiency disorders. Our methodology for comparing immune responses of bacterial preparations may provide a useful tool for studying immune effects of pathogenic and non-pathogenic bacteria.
Microstructure characteristics of saturated remolded cohesive soil during consolidation: an experimental study
Authors: Zheng Juan , Yang Zhen , Gao Huabin , Lai Xiuying , Wu Xiao , Huang Yaolong 
Published: August 2022

Abstract
In this paper, drained consolidation tests of saturated remolded cohesive soil were carried out at different loading rates, and the samples at different loading stages were measured by nuclear magnetic resonance (NMR) testing. Through qualitative analysis of the relationship between the transverse relaxation time T2, peak area, and porosity, the deformation micro-response of the saturated remolded cohesive soil was studied. The results showed that the transverse relaxation time T2 of the saturated remolded cohesive soil samples during the initial stage consisted of two spectral peaks, representing pores with large and small pore diameters, respectively. As loading progressed, the pore diameters in each sample group gradually shifted to smaller sizes, and the final form of the T2 spectrum was unimodal, in which the pores became denser and more uniform. In the initial stage of loading, the T2 spectrum of the soil sample with faster loading showed no obvious change trend due to the influence of drainage lag. After a sufficiently long dead load time, the final shape of the T2 spectrum was very similar regardless of loading rate, indicating that the loading rate only affected the intermediate state of the soil sample, and the final state was determined by the initial state of the sample. At the same time, after a certain dead load time, the changes in pore diameter were no longer obvious, indicating that the flowing fluid in the pore was drained, and drainage consolidation was complete. According to the positive correlation between the loading rate and maximum pore pressure, a boundary rate was obtained. We could reasonably infer that if the controlled loading rate was less than this value, drainage consolidation was complete in the main consolidation stage.
A Study on Disability Glare Vision in Young Adult Subjects
Authors: Casado Pilar , Ávila Francisco J. , Collados Mª Victoria , Ares Jorge 
Published: August 2022

Abstract
The complete assessment of the visual system must include evaluation of the optical quality of the eye and neural visual functions. The objective evaluation of the retinal image quality is often carried-out by computing the point spread function (PSF) of the eye. The central part of the PSF is associated to optical aberrations and the peripheral areas to scattering contributions. In that sense, visual acuity and contrast sensitivity function tests can be considered the perceptual neural response to those contributions characterizing the eye´s PSF. However, in natural viewing conditions visual acuity tests may provide good vision while contrast sensitivity tests can reveal visual impairment in glare vision conditions, such as exposure to bright light sources or night driving conditions. Here we present an optical instrument for the study of disability glare vision under Maxwellian illumination to assess the contrast sensitivity function under glare conditions. The limit of the total disability glare threshold, tolerance and glare adaptation will be investigated as a function of the glare angle and the contrast sensitivity function in young adult subjects.
The double-edged sword of Twitter during crisis situations. A value-sensitive design approach to decreasing the impact of online misinformation
Authors: Engelen Yves van , Marin Lavinia 
Published: August 2022

Abstract
Social media platforms like Twitter are extensively used during crises which seems to be a double-edged sword. On one hand, these platforms have an invaluable potential to become a reliable source of information and communication-tool for those involved in crisis situations. On the other hand, it is already known that current social media platforms allow misinformation to spread quickly - a fact that, in crisis situations, could widely jeopardize public safety. The reasons why misinformation spreads so quickly on Twitter in crisis situations can be traced back to several factors such as the platform’s design choices, as well as the user's lack of critical engagement with the information, but, as we argue in this article, also because of an inherent value hierarchy embedded in the design of the user interface. In this paper, we aim to first clarify what can be done effectively by Twitter to mitigate the spread of misinformation in crisis situations. By using a Value Sensitive Design framework, we argue that the current Twitter design promotes a multiplicity of values that are implemented in the user-interface design in ways that lead to conflicting effects on misinformation. We thus argue that a design intervention needs to change both the current value hierarchy and the design implementations of the values at stake. Our paper concludes with several design recommendations for elevating the user's critical engagement as well as a discussion about the moral implications of trying to streamline Twitter’s user interface design towards favouring truth-telling in situations of crisis.
Mobile Integrated Access and Backhaul Node Backhual Link Failure Recovery with CHO
Authors: Huang Zhihan , Xu Xiaodong , Li Haojin , Wang Shuo , Sun Chen 
Published: August 2022

Abstract
Mobile integrated access and backhaul (IAB) has become an important topic and potential technology to discuss in beyond fifth generation(B5G) because the mobility of IAB nodes seriously affects the performance of networks and results in frequent backhaul radio link failure(BH RLF). In this paper, to recover from backhaul failures, we consider methods using the advanced preparation of alternative backhaul links and routes, such as conditional handover (CHO), to recover from backhaul failures. We propose two solutions to this issue, including cell selection based on parameter prediction and pre-configured priority and a force trigger CHO event in different scenarios. When RLF occurs in the mobile IAB nodes own BH link, the priority of the CHO candidate cell should be increased, effectively improving the selection probability of CHO candidate cells. When RLF occurs in the mobile IAB nodes parent BH link, we propose a new CHO trigger event to ensure that when its own link is intact, CHO will be triggered. Through theoretical analysis, we show that our solutions effectively reduce backhaul link failure.
A Pilot Study of Ion Current Estimation by Artificial Neural Network from Action Potential Waveforms
Authors: AYAN Sevgi ŞENGÜL , Süleymanoğlu Selim , Özdoğan Hasan 
Published: August 2022

Abstract
Experiments using conventional experimental approaches to capture the dynamics of ion channels are not always feasible, and even when possible and feasible, some can be time-consuming. In this work, the ionic current-time dynamics during cardiac action potentials (APs) are predicted from a single AP waveform by means of artificial neural networks (ANNs). The data collection is accomplished by the use of a single-cell model to run electrophysiological simulations in order to identify ionic currents based on fluctuations in ion channel conductance. The relevant ionic currents, as well as the corresponding cardiac AP, are then calculated and fed into the ANN algorithm, which predicts the desired currents solely based on the AP curve. The validity of the proposed methodology for the Bayesian approach is demonstrated by the R (validation) scores obtained from training data, test data, and the entire data set. The Bayesian regularization's (BR) strength and dependability are further supported by error values and the regression presentations, all of which are positive indicators. As a result of the high convergence between the simulated currents and the currents generated by including the efficacy of a developed Bayesian solver, it is possible to generate behavior of ionic currents during time for the desired AP waveform for any electrical excitable cell.
A general tensor prediction framework based on graph neural networks
Authors: Xiang Hongjun , Zhong Yang , Yu Hongyu , Gong Xinggao 
Published: August 2022

Abstract
Graph neural networks (GNNs) have shown extremely high flexibility and accuracy in predicting the physical properties of molecules and crystals. However, traditional invariant GNNs are not compatible with directional properties, which currently limits their application only to the prediction of invariant scalar properties. To address this issue, here we propose a general framework, i.e., an edge-based tensor prediction graph neural network (ETGNN), where a tensor is expressed as the linear combination of the local spatial components projected on the edge directions of multiple-sized clusters. This tensor decomposition is rotationally equivariant and exactly satisfies the symmetry of the local structures, while the coefficients before each local spatial component are rotationally invariant scalars which can be easily predicted by traditional invariant GNNs. The accuracy and universality of our new framework are demonstrated by the successful prediction of various tensor properties from first-order to third-order. The framework proposed in this work will enable GNNs to step into the broad field of the prediction of directional properties.
Germ-cell specific eIF4E1B regulates maternal RNA translation
to ensure zygotic genome activation
Authors: Yang Guanghui , Xin Qiliang , Feng Iris , Dean Jurrien 
Published: August 2022

Abstract
Translation of maternal mRNAs is detected before transcription of zygotic genes and is essential for mammalian embryo development. How certain maternal mRNAs are selected for translation instead of degradation and how this burst of translation affects zygotic genome activation remains unknown. Using gene-edited mice, we document that the eukaryotic translation initiation factor 4E family member 1B (eIF4E1B) is the regulator of maternal mRNA translation that ensures subsequent reprogramming of the zygotic genome. In oocytes, the germ-cell specific eIF4E1B binds to mRNAs encoding chromatin remodeling complexes as well as reprogramming factors to protect them from degradation and promote their translation in zygotes. These protein products establish an open chromatin landscape in one-cell zygotes and enable transcription. Our results define a program for rapid resetting of the zygotic epigenome that is regulated by maternal mRNA translation and provides new insight into the mammalian maternal-to-zygotic transition.
Reduced Anti-Müllerian Hormone Levels in Males with Inherited Bone Marrow Failure Syndromes
Authors: Stratton Pamela , Giri Neelam , Sklavos Martha M , Alter Blanche P , Savage Sharon A , Pinto Ligia A 
Published: August 2022

Abstract

Purpose
Fanconi Anemia (FA), dyskeratosis congenita/telomere biology disorders (DC/TBD), and Diamond-Blackfan anemia (DBA) are inherited bone marrow failure syndromes (IBMFS) with high risks of bone marrow failure, leukemia, and solid tumors. Anti-Müllerian hormone (AMH), a circulating marker of ovarian reserve in females, may be a direct marker of Sertoli cell function and an indirect marker of spermatogenesis in males. Previously, reduced levels of AMH were found in females with these syndromes.
Methods
We assessed serum AMH levels in pubertal and post-pubertal males with FA, DC/TBD or DBA compared with their unaffected male relatives and unrelated healthy male volunteers participating in an observational study of the National Cancer Institute’s IBMFS cohort at the National Institutes of Health Clinical Center.
Results
Males with FA had significantly lower levels of AMH (median 5 ng/mL) compared with unaffected male relatives (median 7.31 ng/mL, P = 0.03) or healthy male volunteers (median 7.66 ng/mL, P = 0.008). Males with DC/TBD had lower levels of AMH (median 3.76 ng/mL) compared with unaffected relatives (median 5.31 ng/mL, P = 0.01) or healthy volunteers (median 5.995 ng/mL, P < 0.001). Males with DBA had similar levels of AMH (median 3.46 ng/mL) as unaffected relatives (median 4.66 ng/mL, P = 0.56), and healthy volunteers (median 5.81 ng/mL, P = 0.10).
Conclusion
Our findings suggest a defect in the production of AMH in post-pubertal males with FA and DC/TBD, similar to that observed in females.
Emotion Recognition and the Screening Instrument for Borderline Personality Disorder (SI-Bord): outcomes and community-based validation
Authors: Godfrey Emmet , Kelly-Grealy Molly , O’Sullivan Erin Whyte , Sullivan Sarah , Brady Finn , Carroll Grace A. , Burke Tom 
Published: August 2022

Abstract
Background
Borderline Personality Disorder (BPD) is a psychiatric condition characterized by impulsivity, affect instability, dysregulation, low self-image, and interpersonal difficulties. There are many instruments to measure traits of BPD, however few can be administered quickly. The SI-Bord is an instrument offering a brief administration time with comparable psychometric properties to more comprehensive measures. The present study aimed to evaluate the psychometric properties of the SI-Bord in a healthy community-based sample and its relatedness to measures of social cognition.
Methods
A community-based sample of participants completed an online survey consisting of measures of BPD traits and social cognition consisting of the Screening Instrument for Borderline Personality Disorder (SI-Bord), the Personality Assessment Inventory (PAI), the Florida Affect Battery (FAB), the Interpersonal Reactivity Index (IRI), and the Narcissistic Personality Inventory (NPI). Reliability was assessed using Cronbach’s alpha and inter-item correlations. Validity was assessed using factor analysis, examining associations with other measures of BPD traits, and examining associations with measures not measuring BPD traits.
Results
151 participants were included in the study. Participants’ age ranged from 20–76 (mean age of 38.79 ± 12.37) and comprised 76 females (50.33%) and 75 males (49.67%). Good internal consistency was found with a Cronbach’s alpha of .71. Good inter-item reliability was found with a mean inter-item cross correlation of .25, with each item of the SI-Bord showing an inter-item correlation coefficient of > .5. Factor analysis identified good construct validity with a strong singular dimension explaining a large proportion of variance. The SI-Bord showed good concurrent validity with significantly positive correlations with the subscales of the PAI borderline scale measuring affect instability (r = .60; p < .001), identity problems (r = .67; p < .001), negative relationships (r = .61; p < .001), self-harm (r = .39; p < .001), and total score (r = .76; p < .001). The SI-Bord was not correlated with the NPI-16 (r = .131; p = .11), showing good divergent validity.
Conclusions
These findings support the efficacy of the SI-Bord as a quick and useful screening tool in the diagnostic process of BPD.