bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breastfeeding at 6 months of age had a positive impact on overweight and obesity in Japanese adolescents at 15 years of age
Authors: Kadowaki Tomoka , Matsumoto Naomi , Suzuki Etsuji , Mitsuhashi Toshiharu , Takao Soshi , Yorifuji Takashi 
Published: September 2022

AbstractAimA number of studies have indicated the potential benefits that breastfeeding has on reducing childhood obesity, but few studies have evaluated the effect on adolescent obesity. We examined the association between breastfeeding and overweight or obesity at 15 years of age using data from a large nationwide longitudinal study launched by the Japanese Government in 2001.MethodsWe analysed data for 26 164 participants with known infant feeding practices at 6 months of age, namely the duration of breastfeeding or formula feeding. Overweight or obesity at 15 years of age were calculated based on the subject's self‐reported height and weight. Multinomial logistic regression analysis adjusted the data for child factors, namely sex, siblings, birth weight and physical activity clubs and the maternal factors of age, educational attainment and smoking status.ResultsFormula feeding was associated with an increased risk of overweight or obesity at 15 years of age. The adjusted odds ratios (95% confidence intervals) were 0.99 (0.89–1.09) for partial breastfeeding and 1.23 (1.02–1.48) for formula feeding, when exclusive breastfeeding was the reference category.ConclusionBreastfeeding during infancy had potential benefits for overweight or obesity among 15‐year‐old adolescents. Our results provide further evidence of the importance of breastfeeding.
Infliximab as a second‐line therapy for children with refractory Kawasaki disease: A systematic review and meta‐analysis of randomized controlled trials
Authors: Kabbaha Suad , Milano Alyssa , Aldeyab Mamoon A. , Thorlund Kristian 
Published: September 2022

AimsInfliximab is a tumour necrosis factor‐alpha inhibitor that is used to treat children with refractory Kawasaki disease (KD). Our purpose was to evaluate the safety and impact of infliximab versus intravenous immunoglobulins on the incidence of coronary artery aneurysms (CAAs) and treatment resistance in children with refractory KD.MethodsThe Medline/PubMed, Embase, CINAHL, Cochrane Central Register of Controlled Trials and clinical trials registries were searched to December 2021. Randomized controlled trials (RCTs) comparing infliximab as second‐line therapy to a second dose of intravenous immunoglobulin (IVIG) in children with refractory KD, reported in abstract or full text, were included. Studies were selected and assessed for risk of bias by two reviewers. Data were extracted and pooled using conventional random‐effects meta‐analysis. The certainty of evidence was assessed using the GRADE system.ResultsA total of 199 participants from four RCTs were included. The pooled risk ratio (RR) for the incidence of treatment resistance in patients treated with infliximab was 0.40 (95% confidence interval [CI] 0.25‐0.64). For incidence of CAAs RR was 1.20 (95% CI 0.54‐2.63), the incidence of adverse effect “infusion reactions” RR was 0.48, (95% CI 0.12‐1.92) and for “infections” RR was 0.55 (95% CI 0.27‐1.12). Overall, the GRADE strength of evidence for the primary outcomes was low. Evidence on the duration of fever and inflammatory biomarkers was sparse, heterogeneous and inconclusive.ConclusionModerate‐certainty evidence indicates that infliximab may reduce the incidence of treatment resistance in children with refractory KD. However, the limited strength of evidence warrants further research.
TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β‐catenin signalling
Authors: Pagano Ester , Romano Barbara , Cicia Donatella , Iannotti Fabio A. , Venneri Tommaso , Lucariello Giuseppe , Nanì Maria Francesca , Cattaneo Fabio , De Cicco Paola , D'Armiento Maria , De Luca Marcello , Lionetti Ruggiero , Lama Stefania , Stiuso Paola , Zoppoli Pietro , Falco Geppino , Marchianò Silvia , Fiorucci Stefano , Capasso Raffaele , Di Marzo Vincenzo , Borrelli Francesca , Izzo Angelo A. 
Published: September 2022

AbstractBackground and PurposeTransient receptor potential melastatin type‐8 (TRPM8) is a cold‐sensitive cation channel protein belonging to the TRP superfamily of ion channels. Here, we reveal the molecular mechanism of TRPM8 and its clinical relevance in colorectal cancer (CRC).Experimental ApproachTRPM8 expression and its correlation with the survival rate of CRC patients was analysed. To identify the key pathways and genes related to TRPM8 high expression, Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were conducted in CRC patients. TRPM8 functional role was assessed by using Trpm8−/− mice in models of sporadic and colitis‐associated colon cancer. TRPM8 pharmacological targeting by WS12 was evaluated in murine models of CRC.Key ResultsTRPM8 is overexpressed in colon primary tumours and in CD326+ tumour cell fraction. TRPM8 high expression was related to lower survival rate of CRC patients, Wnt–Frizzled signalling hyperactivation and adenomatous polyposis coli down‐regulation. In sporadic and colitis‐associated models of colon cancer, either absence or pharmacological desensitization of TRPM8 reduced tumour development via inhibition of the oncogenic Wnt/β‐catenin signalling. TRPM8 pharmacological blockade reduced tumour growth in CRC xenograft mice by reducing the transcription of Wnt signalling regulators and the activation of β‐catenin and its target oncogenes such as C‐Myc and Cyclin D1.Conclusion and ImplicationsHuman data provide valuable insights to propose TRPM8 as a prognostic marker with a negative predictive value for CRC patient survival. Animal experiments demonstrate TRPM8 involvement in colon cancer pathophysiology and its potential as a drug target for CRC.
Joint inversion of temperature, vitrinite reflectance and fission tracks in apatite with examples from the eastern North Sea area
Authors: Nielsen Søren B. , Balling Niels 
Published: September 2022

AbstractAs sediment accumulation indicates basin subsidence, erosion often is understood as tectonic uplift, but the amplitude and timing may be difficult to determine because the sedimentary record is missing. Quantification of erosion therefore requires indirect evidence, for example thermal indicators such as temperature, vitrinite reflectance and fission tracks in apatite. However, as always, the types and quality of data and the choice of models are important to the results. For example, considering only the thermal evolution of the sedimentary section discards the thermal time constant of the lithosphere and essentially ignores the temporal continuity of the thermal structure. Furthermore, the types and density of thermal indicators determine the solution space of deposition and erosion, the quantification of which calls for the use of inverse methods, which can only be successful when all models are mutually consistent. Here, we use integrated basin modelling and Markov Chain Monte Carlo inversion of four deep boreholes to show that the erosional pattern along the Sorgenfrei–Tornquist Zone (STZ) in the eastern North Sea is consistent with a tectonic model of tectonic inversion based on compression and relaxation of an elastic plate. Three wells in close proximity SW of the STZ have different data and exhibit characteristic differences in erosion estimates but are consistent with the formation of a thick chalk sequence, followed by minor Cenozoic erosion during relaxation inversion. The well on the inversion ridge requires ca. 1.7 km Jurassic‐Early Cretaceous sedimentation followed by Late Cretaceous–Palaeocene erosion during inversion. No well demands thick Cenozoic sedimentation followed by equivalent significant Neogene exhumation. When data are of high quality and models are consistent, the thermal indicator method yields significant results with important tectonic and geodynamic implications.
Lacosamide decreases neonatal seizures without increasing apoptosis
Authors: Langton Rachel L. , Sharma Shaunik , Tiarks Grant C. , Bassuk Alexander G. , Glykys Joseph 
Published: September 2022

AbstractObjectiveMany seizing neonates fail to respond to first‐line anticonvulsant medications. Phenobarbital, an allosteric modulator of γ‐aminobutyric acid type A (GABAA) receptors, has low efficacy in treating neonatal seizures and causes neuronal apoptosis. Nonetheless, it is one of the most used anticonvulsants in this age group. In neonatal mice, phenobarbital's poor effectiveness is due in part to high intraneuronal chloride concentration, which causes GABA to exert depolarizing actions. Therefore, another approach to treat neonatal seizures could be to use anticonvulsants that do not rely on GABAergic modulation. We evaluated whether lacosamide decreases seizures in neonatal mice and whether it increases apoptosis in vitro and in vivo.MethodsIn vitro, we measured the effect of different lacosamide concentrations on seizure‐like activity induced by the pro‐convulsant drug 4‐aminopyridine in neocortical brain slices (layer IV/V) from neonatal (postnatal day 8–11) and adult (1–1.6 months old) C57BL/6J mice. In vivo, we recorded the effect of different lacosamide concentrations on neonatal behavioral seizures induced by kainic acid. We studied neocortical apoptosis in vitro and in vivo, measuring terminal deoxynucleotidyl transferase (TdT) dUTP nick‐end labeling signal and cleaved‐caspase 3.ResultsLacosamide reduced epileptiform activity in neocortical brain slices of neonates and adults in a concentration‐dependent manner. In vivo, lacosamide reduced the duration and number of behavioral seizures. Lacosamide did not increase total or neuronal apoptosis in the neocortex in vitro or in vivo.SignificanceLacosamide reduces neocortical seizure‐like activity in neonatal mice in vitro and in vivo without an acute increase in apoptosis. Our results support the use of lacosamide to treat neonatal seizures, with the advantage of not increasing apoptosis acutely.
Long‐term series variation in fishery biology of Dosidicus gigas off Peru: Response to climate variability from 2008 to 2020
Authors: Dan Ya Ting , Liu Bi Lin , Chen Xin Jun , Qian Wei Guo 
Published: September 2022

AbstractAs a cephalopod with a short life cycle, the Dosidicus gigas (jumbo flying squid) is extremely sensitive to climate variability and marine environment changes in terms of individual growth and resource changes. Based on 7514 D. gigas samples collected off Peru from 2008 to 2020, the fishery biological characteristics such as size, sexual maturity, and size‐at‐maturity were analyzed to explore the impacts of climate variability on individual growth. The results showed that there were significant differences in the relationship between mantle length and body weight and in the composition of sexual maturity between male and female individuals in different years (P < .05). La Niña events were conducive to the individual growth of D. gigas and slowed down their sexual maturity, producing D. gigas groups in medium and large sizes; El Niño events inhibited the individual growth of D. gigas and accelerated their sexual maturity, producing D. gigas groups in a smaller size. From 2008 to 2020, the mantle length of the small‐size group decreased by 46 mm, while that of the medium‐size group increased by 28 mm. Size‐at‐maturity of female D. gigas decreased by 201.2 mm and that of male D. gigas decreased by 143 mm. The study concluded that the changes in the marine environment caused by climate variability from 2008 to 2020 have had a significant impact on the population structure, growth, and development of the D. gigas off Peru.
Translating and applying a simulation model to enhance understanding of grassland management
Authors: Giannitsopoulos Michail L. , Burgess Paul J. , Bell Matthew J. , Richter Goetz M. , Topp Cairistiona F. E. , Ingram Julie , Takahashi Taro 
Published: September 2022

AbstractEach new generation of grassland managers could benefit from an improved understanding of how modification of nitrogen application and harvest dates in response to different weather and soil conditions will affect grass yields and quality. The purpose of this study was to develop a freely available grass yield simulation model, validated for England and Wales, and to examine its strengths and weaknesses as a teaching tool for improving grass management. The model, called LINGRA‐N‐Plus, was implemented in a Microsoft Excel spreadsheet and iteratively evaluated by students and practitioners (farmers, consultants, and researchers) in a series of workshops across the UK over 2 years. The iterative feedback led to the addition of new algorithms, an improved user interface, and the development of a teaching guide. The students and practitioners identified the ease of use and the capacity to understand, visualize and evaluate how decisions, such as variation of cutting intervals, affect grass yields as strengths of the model. We propose that an effective teaching tool must achieve an appropriate balance between being sufficiently detailed to demonstrate the major relationships (e.g., the effect of nitrogen on grass yields) whilst not becoming so complex that the relationships become incomprehensible. We observed that improving the user‐interface allowed us to extend the scope of the model without reducing the level of comprehension. The students appeared to be interested in the explanatory nature of the model whilst the practitioners were more interested in the application of a validated model to enhance their decision making.
Efficacy and feasibility of cryoballoon ablation for atrial fibrillation in patients with heart failure: A large‐scale multicenter study
Authors: Yanagisawa Satoshi , Suzuki Hirohiko , Kanzaki Yasunori , Ishikawa Shinji , Kamikubo Yosuke , Okumura Satoshi , Kato Hiroyuki , Mizutani Yoshiaki , Murase Yosuke , Nakasuka Kosuke , Warita Shunichiro , Sekimoto Satoru , Takemoto Yoshio , Takasugi Nobuhiro , Ohguchi Shiou , Senga Michiharu , Yokoi Kenichiro , Shibata Rei , Inden Yasuya , Murohara Toyoaki 
Published: September 2022

AbstractIntroductionData are limited regarding outcomes of cryoballoon ablation for atrial fibrillation (AF) in patients with heart failure (HF). This large‐scale multicenter study aimed to evaluate the prognosis of patients with HF after cryoballoon ablation for AF.MethodsAmong 3655 patients undergoing cryoballoon ablation at 17 institutions, 549 patients (15%) (391 with paroxysmal AF and 158 with persistent AF) diagnosed with HF preoperatively were analyzed. Clinical endpoints were recurrence, mortality, and HF hospitalization after ablation.ResultsMost patients had a preserved left ventricular ejection fraction (LVEF) ≥ 50%. During a mean follow‐up period of 25.7 months, recurrence, all‐cause death, and HF hospitalization occurred in 29%, 4.0%, and 4.8%, respectively. Cardiac function on echocardiography and B‐type natriuretic peptide (BNP) levels significantly improved postoperatively, and the effect was more pronounced in the nonrecurrence group. Major complications occurred in 33 patients (6.0%), but most complications were phrenic nerve palsy (3.6%). Although death and HF hospitalization occurred more frequently in patients with LVEF ≤ 40% (n = 73) and New York Heart Association (NYHA) class III–IV (n = 19) than other subgroups, the BNP levels, and LVEF significantly improved after ablation in all LVEF and NYHA class subgroups. High BNP levels, NHYA class, CHADS2 score, and structural heart disease, but not postablation recurrence, independently predicted death, and HF hospitalization on multivariate analysis. The patients with tachycardia‐induced cardiomyopathy had better recovery of BNP levels and LVEF after ablation than those with structural heart disease.ConclusionsCryoballoon ablation for AF in HF patients is feasible and leads to significantly improved cardiac function.
Effects of nonthermal dielectric barrier discharge plasma against Listeria monocytogenes and quality of smoked salmon fillets
Authors: Roy Pantu Kumar , Jeon Eun Bi , Park Shin Young 
Published: September 2022

AbstractThe objective was to explore the effects of dielectric barrier discharge (DBD) plasma on bacterial reduction, physiological characteristics (pH and moisture), and sensorial quality against Listeria monocytogenes on the surface of smoked salmon. Reductions were treated with 5, 10, 20, 30, 40, 50, and 60 min with DBD plasma varied from 0.17, 0.25, 0.32, 0.70, 0.81, 1.05, and 1.25 log10 CFU/g, respectively. The R2 and D‐value of L. monocytogenes was .98 and 49.01 min, respectively. However, moisture levels were significantly different after 30 and 60 min of treatment compared with the control but pH and the sensory qualities were not. This study found that treated with 60 min DBD plasma reduced L. monocytogenes by more than 90% without negatively affecting the smoked salmon. Based on these results, antibacterial treatment for smoked salmon, and this strategy could be explored in the seafood industry to increase food safety.
Older adults' perspectives on primary care telemedicine during the COVID‐19 pandemic
Authors: Bhatia Roma , Gilliam Elizabeth , Aliberti Gianna , Pinheiro Adlin , Karamourtopoulos Maria , Davis Roger B. , DesRochers Laura , Schonberg Mara A. 
Published: September 2022

AbstractBackgroundPrior to the COVID‐19 pandemic there were many barriers to telemedicine primary care for adults ≥65 years including insurance coverage restrictions and having lower digital access and literacy. With the pandemic, insurance coverage broadened and many older adults utilized telemedicine creating an opportunity to learn from their experiences to inform future policy.MethodsBetween April 2020 and June 2021, we conducted a cross‐sectional multimethod study of English‐speaking, cognitively‐intact, adults ≥65, who had a phone‐only and/or video telemedicine visit with their primary care physician within one large Massachusetts health system (10 different practices) since March 2020. The study questionnaire asked participants their overall satisfaction with telemedicine (7‐point scale) and to compare telemedicine with in‐person care. We used linear regression to examine the association between participants' demographics, Charlson comorbidity score, and survey completion date with their satisfaction score. The questionnaire also included open‐ended questions on perceptions of telemedicine; which were analyzed using qualitative methods.ResultsOf 278 eligible patients reached, 208 completed the questionnaire; mean age was 74.4 years (±4.4), 61.5% were female, 91.4% were non‐Hispanic White, 64.4% had ≥1 comorbidity, and 47.2% had a phone‐only visit. Regardless of their age, participants reported being satisfied with telemedicine; median score was 6.0 on the 7‐point scale (25th percentile = 5.0 and 75th percentile = 7.0). Non‐Whites satisfaction scores were on average 1 point lower than those of non‐Hispanic Whites (p = 0.02). Those with comorbidity reported scores that on average were 0.5 points lower than those without comorbidity (p = 0.07). Overall, 39.5% felt their telemedicine visit was worse than in‐person care; 4.9% thought it was better. Participants appreciated telemedicine's convenience but described frustrating technical challenges. While participants preferred in‐person care, most wanted telemedicine to remain available.ConclusionsAdults ≥65 reported being satisfied with primary care telemedicine during the pandemic's first 14 months and wanted telemedicine to remain available.
Anxiety and depression in small fiber neuropathy
Authors: Damci Aysun , Schruers Koen R. J. , Leue Carsten , Faber Catharina G. , Hoeijmakers Janneke G. J. 
Published: September 2022

AbstractPsychiatric comorbidity is common in patients with chronic pain. In peripheral neuropathic pain, particularly anxiety and mood disorders are frequently present and associated with a high level of catastrophizing. Small fiber neuropathy (SFN) is a peripheral neuropathy dominated by pain. This study aimed to investigate the prevalence of and factors associated with anxiety and depressive symptoms in SFN. All consecutive patients diagnosed with SFN at Maastricht University Medical Center+, between September 2016 and October 2021, were included (n = 1310). Data on demographics, medical history, diagnostic tests, and questionnaires about pain, SFN‐specific symptoms, and mental health were collected once. The Hospital Anxiety and Depression Scale (HADS) was used to measure anxiety and depression and the Pain Catastrophizing Scale (PCS) to measure the degree of catastrophizing. One‐third of the patients had an abnormal HADS score (≥11) on the subscales anxiety and/or depression (26.5% anxiety and 23.0% depression) indicating clinical relevance. Regression analysis showed that higher pain intensity, catastrophizing, and more SFN‐related complaints were significantly associated with an abnormal HADS‐score. In conclusion, the prevalence of reported anxiety or depressive symptoms in SFN is 36.3%. A multidisciplinary approach, not only focusing on pain relief, is therefore essential for the treatment of SFN.
Stigma as Moral Insurance: How Stigma Buffers Firms from the Market Consequences of Greenwashing
Authors: Kassinis George I. , Kay Adam A. , Papagiannakis Giorgos , Vlachos Pavlos A. 
Published: September 2022

AbstractOrganizational stigma is widely assumed to be a serious liability. However, a small body of research has begun to show that stigma can also lead to positive outcomes. A core assumption of this budding literature is that realizing a benefit from stigma requires firms to take active and strategic measures to turn stigma to their advantage. Shedding new light on this assumption, in the present research we show that stigma has a built‐in insurance‐like quality that buffers firms from the market consequences of their misconduct. Specifically, we demonstrate that when firms are caught greenwashing, organizational stigma protects them from consumer backlash, with no effort required on their part to realize this benefit. Across a longitudinal panel data study tracking 7365 firms in 47 countries over a 15‐year period, plus an experiment, we show that stigmatized firms are subjected to less market discipline for greenwashing. We further demonstrate that the mechanism driving this phenomenon is a certain ‘boys will be boys’ expectation by consumers that stigmatized firms lack integrity and, by consequence, are given greater leeway to greenwash. In so doing, we move beyond prior research focusing on the strategies firms can deploy to leverage stigma to their advantage, highlighting instead the psychological mechanisms that make organizational stigma more than a liability to be overcome in the marketplace, but also an asset.