bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of hydroxypropyl methylcellulose with corn silk polysaccharides to enhance packaging performance and stability of low moisture mozzarella cheese
Authors: Abdin Mohamed , Ali Mostafa , Elmahdy Ahmed , Naeem Mohamed Ahmed 
Published: October 2022

Abstract
A novel film composed from hydroxypropyl methylcellulose (HPM) and corn silk polysaccharides (CSP) was prepared (HPM-CS). The effects of substituting different percentages from HPM with CSP on HPM-CS characteristics were investigated. The substituting of HPM by 37.5% of CSP enhanced mechanical properties 58.71% for tensile strength (TS) and 54.29% for elongation at break (EB), opacity, antioxidant activities, smooth and continuous surface without any grooves and biodegradability of produced films. However, the presence of CSP inside HPM-CS films reduced thermal stability and disturbed the crystallinity shapes at high concentrations. The best HPM concentration (1g/100mL) sample with optimum CSP concentration of (0.6g/ 100) mL was used as food wrapping material for low-moisture mozzarella cheese. The packaging material kept the stability of total microbial count in hygienic scale up to 40 days of cold storage, moisture loss and pH values up to 30 days. Additionally, the results of hedonic sensory evaluation were satisfied compared with fresh cheese until 30 days of storage.
Diminished LAG3+ B cells correlate with exacerbated rheumatoid arthritis
Authors: Hu Suiyuan , Tao Yuting , Hu Fanlei , Liu Xu 
Published: October 2022

Abstract
Background
Regulatory B (Breg) cells negatively regulate immunity, and the impairment of Breg cells participates in the pathogenesis of rheumatoid arthritis (RA). Lymphocyte activation gene-3 (LAG3) is an inhibitory receptor involved in maintaining immune tolerance. LAG3+ B cells have been identified as a novel regulatory B cell subset. Nevertheless, its role in RA remains elusive.
Methods
Peripheral blood mononuclear cells (PBMCs) from RA, osteoarthritis (OA) patients and healthy volunteers were collected for flow cytometry staining of LAG3+ cells in different B cell subsets. Their frequencies with the clinical features and immunological characteristics of the RA patients were then analyzed. Moreover, collagen-induced arthritis (CIA) mouse models were also established for the detection of LAG3 + B cells and their potential involvement in the disease.
Results
A significant downregulation of LAG3+ B cells was observed in RA lymphocytes as well as B cell subsets as compared with healthy individuals and OA patients. Notably, the frequencies of LAG3+ B cells were negatively correlated with tender joint count (r = -0.4301, p = 0.0157) and DAS28-ESR (r = -0.4018, p = 0.025) in RA patients. In CIA mouse models, LAG3+ B cell frequencies in LAG3+ CD86+ B cells, LAG3+ CD80+ B cells, LAG3+ CD69+ B cells and LAG3+ plasma B cells were also decreased, negatively correlating with the CIA arthritis score.
Conclusions
Impairment of LAG3+ B cells potentially contribute to the initiation and development of RA. Reconstituting LAG3+ B cells might provide novel therapeutic strategies for the persistent disease.
Maternal and Neonatal Outcomes following COVID-19 Vaccination in Pregnancy
Authors: Ali Hosseini Nasab , Shahrzad Sanjari , Reza Mohammidi Soleimani Mohammad , Mohammadreza Kashani , Katayoun Alidousti 
Published: October 2022

Abstract
Background
The physiological and anatomical changes that occur during pregnancy make the mother vulnerable to severe infections and reduce the mother's tolerance to hypoxia. Vaccination is a fundamental strategy to prevent diseases.The present study was done with the aim of investigating maternal and neonatal outcomes following COVID-19 vaccination in Pregnancy.
Methods
This cross-sectional study was carried out on 1645 pregnant women (685 COVID-19 vaccinated during pregnancy and 960 non- vaccinated). The study was conducted in the public hospitals of Kerman, located in southeastern of Iran, from January to March ,2022. Maternal and neonatal outcomes were measured by interview and observation during labor, delivery and postpartum.
Results
All vaccinated women had received the Sinopharm vaccine The mean birth weight of the neonates was 2778.9 ± 877.9 grams in the vaccinated and 2827 ± 843.6 grams in the non-vaccinated group. The first minute Apgar score was 8.05 ± 1.89 in the vaccinated and 8.15 ± 2.05 in the non-vaccinated group. The risk of maternal morbidities was not significantly different in two groups (p > 0.001). Only the risk of NICU admission was higher in vaccinated women than in non-vaccinated women (OR = 3.39, P < 0.001).
Conclusions
Since serious complications associated with receiving COVID-19 vaccines during pregnancy were not observed in the present study, and COVID-19 can have serious and fatal effects during pregnancy, it seems reasonable to recommend vaccination during pregnancy to prevent the potential risk posed by COVID-19.
Clinical and Genetic Spectrums of Pediatric Cardiomyopathies: Experience from a Tertiary Pediatric Cardiology Centre in Hong Kong
Authors: Shi Zhuo Julia , Chau Fong Ting Jeffrey , Kwok Sit Yee , Yeung Kit San , Fung Lee Fong Jasmine , Kwong Ka Yee Anna , Yung Tak Cheung , Chung Hon Yin Brian , Lun Kin Shing 
Published: October 2022

Abstract
Background
Pediatric cardiomyopathies are rare conditions associated with substantial morbidity and mortality. This study aims at reporting the clinical and genetic spectrums of pediatric cardiomyopathy in the single tertiary centre in the Hong Kong.
Study Design
: All primary cardiomyopathy patients who were ≤ 18 years old and followed up in our pediatric cardiology clinic were analyzed. Whole exome sequencing was offered to patients who did not have molecular diagnosis identified with prior single gene or panel testing.
Results
45 unrelated patients were identified, including 19 (42.2%) with hypertrophic cardiomyopathy, 20 (44.4%) with dilated cardiomyopathy, three (6.7%) with restrictive cardiomyopathy, and three (6.7%) with left ventricular non-compaction. Pathogenic and likely pathogenic variants were identified in 19 of 41 patients, resulted in an overall diagnostic yield of 46.3%. Among these patients, nine (47.4%) patients had an inherited disorder of the RAS/MASPK signal transduction pathway (BRAF, LZTR1, PTPN11 and RAF1), six (31.6%) harbored mutations in gene associated with primary cardiomyopathy (BAG3, MYBPC3, MYH7, MYL2, RBM20 and TNNT2), and four (21.1%) were diagnosed with syndromic or systemic conditions other than RASopathy (LAMP2, NONO and TAZ). In addition, eight patients carried a variant of uncertain significance (VUS). The presence of syndromic features or extracardiac manifestations was associated with a positive genotype.
Conclusions
The overall diagnostic yield of genetic evaluation was 46%. The study reinforced the utility of genetic assessment in phenotypically confirmed pediatric cardiomyopathy patients, especially for those with syndromic features. Novel mutation of our cohort was reported and described.
A prospective evaluation of high- and low-power holmium laser settings for transurethral lithotripsy in the management of adults with urethral stone
Authors: Wang Yuhuan , Wang Jun , Sun Xiaoping 
Published: October 2022

Abstract
Backgrounds
To compare the effectiveness and safety of high-power (100 W) vs. low-power (20 W) laser settings for transurethral laser lithotripsy in the treatment of urethral stones.
Methods
The trial was open to all patients scheduled for transurethral holmium laser lithotripsy who had urethral stones with the maximal diameter. Either the low-power laser setting or the high-power laser setting was applied to every substitute patient. Using IBM SPSS Statistics 24, we compared the treatment groups' operational times, intraoperative/postoperative problems (up to 1 year), and stone-free rates. Welch tests were used to compare continuous data across treatment groups, whereas Fisher's exact or Chi-square tests were used to evaluate categorical variables. Statistical significance was defined as a p value 0.05.
Results
Two hundred seven people were hired as a result. Both groups' preoperative data and mean bladder stone sizes were similar. When compared to the low-power cohort, the procedure took much less time—42.6111.74 min as opposed to 78.5625.91 min (p = 0.025)—and the ablation rate was significantly higher in the high-power cohort. In neither group were there any substantial intraoperative issues. High power group considerably outperformed low power group in terms of OABSS score and IPSS. According to results of uni- and multivariate logistic regression, the position of the ureteral stone significantly affects how well the therapy works.
Conclusion
When treating urethral stones, a high-power laser setting of up to 100 W significantly reduces the length of the procedure without increasing the risk of complications.
Prenatal prediction of the postnatal biventricular physiology of fetuses with borderline left ventricle
Authors: Kawasaki Yuki , Murakami Yosuke , Ehara Eiji , Fujino Mitsuhiro , Sasaki Takeshi , Nakamura Kae , Suzuki Tsugutoshi , Yoshida Yoko , Hamazaki Takashi 
Published: October 2022

Abstract
Background
Predicting the postnatal biventricular physiology of fetuses with borderline left ventricle remains challenging. This study clarified fetal echocardiographic predictors of successful postnatal biventricular physiology establishment.
Methods
Forty-nine fetuses with a left ventricular (LV) width (LVw) z-score <-2.0, LV length z-score <-2.0, or LVw/right ventricular width (RVw) ratio < 0.8 were retrospectively analyzed. Patients were divided into group B (successful postnatal biventricular physiology; n = 45) and group F (Fontan palliation for LV hypoplasia; n = 4). The z-scores of fetal cardiac structures, left and right cardiac structure ratios, LV diameter (LVd) changes, and flow directions at the foramen ovale (FO) were compared.
Results
The median gestational ages at fetal echocardiography and at birth were 31 weeks and 38 weeks, respectively. The prenatal LVw/RVw ratio, aortic valve (AoV)/pulmonary artery valve (PAV) ratio, AoV z-score, and change in the LVd were significantly higher and the RVw z-score was significantly lower in group B. Of the 42 patients whose blood flow direction was recorded at the FO, right-to-left shunts were identified in 29 (64%) in group B and in 0 in group F. The LVw/RVw ratio, AoV/PAV ratio, and AoV z-score significantly predicted postnatal biventricular physiology. For patients with bidirectional or left-to-right blood flow, the best predictor was the LVw/RVw ratio (cutoff value, 0.571; sensitivity, 100%; specificity, 100%; area under the curve, 1.0).
Conclusions
For patients with borderline left ventricle and heterogeneous cardiac defects, the blood flow direction at the FO and LVw/RVw ratio during the third trimester are good predictors of postnatal biventricular physiology outcomes.
Interaction effect of emotion and social influence on consumers’ purchase intentions of single-use plastic products
Authors: Sun Ying , He Haonan 
Published: October 2022

Abstract
Human health and marine life are facing the hazards and threats of plastic waste. This focus on plastic waste has led the Chinese to pay more attention to the threats and challenges of single-use plastics products. This study aims to explore the interaction between subjective norms and positive anticipated emotions to explain the intention to purchase single-use plastic products based on the theory of planned behavior. Data collection using self-reported questionnaires and analyzed using Amos 22.0 software. Through the questionnaire survey, 402 valid questionnaires were obtained. Results indicate that attitude, perceived behavioral control, normative social influence, informational social influence and positive anticipated emotion positively affects intention to purchase single-use plastic products. Meanwhile, positive anticipated emotion positively moderates the relationship between normative social influence and intention to purchase single-use plastic products, but negatively moderates the relationship between informational social influence and intention to purchase single-use plastic products. The conclusion has a more specific guiding role for decision-makers, manufacturers, and consumers.
Lower gut dysbiosis and mortality in acute critical illness: a systematic review and meta-analysis
Authors: Evans Tess , Ali Umar , Anderton Ryan , Raby Edward , Manning Laurens , Litton Edward 
Published: October 2022

Abstract
Background The human gastrointestinal tract harbours a complex multi-kingdom community known as the microb\iome. Dysbiosis refers to its disruption and is reportedly extreme in acute critical illness, yet its clinical implications are unresolved. The review systematically evaluates the relationship between gut dysbiosis and clinical outcomes of patients early in critical illness.
Methods Following PRISMA guidelines, a prospectively registered search was undertaken of MEDLINE and Cochrane databases for observational studies undertaking metagenomic sequencing of the lower gastrointestinal tract of critically ill adults and children within 72hours of admission. Eligible studies reported an alpha diversity metric and one or more of the primary outcome, all cause mortality, or secondary clinical outcomes. After aggregate data was requested, meta-analysis was performed for 4 studies with mortality stratified to high or low Shannon index.
Results The search identified 26 studies for systematic review and 4 had suitable data for meta-analysis. No effect of alpha diversity was seen on mortality after binary transformation of Shannon index (odds ratio 0.52, CI 0.12–4.98, I2 = 0.64) however certainty of evidence is low. Pathogen dominance and commensal depletion were each more frequently associated with mortality, adverse clinical and ecological sequalae, particularly overabundance of Enterococcus.
Conclusions There is a paucity of large, rigorous observational studies in this population. Globally, alpha diversity was dynamically reduced in early ICU admission and was not associated with in-hospital mortality. The abundance of taxa such as Enterococcus spp. appear to offer greater predictive capacity for important clinical and ecological outcomes.
The effects of heterogeneous environmental regulation on the effectiveness of corporate green investment in China
Authors: Li Mengna 
Published: October 2022

AbstractThe issue of effectiveness is concerning when the entereprise comes to making green investment decisions facing environmental regulations. Existing literature ignores the research on the impact mechanism of different environmental regulations on the effectiveness of corporate green investment (ECGI). Based on the data of listed companies in China's heavily polluting industries from 2017 to 2021, this paper used the data envelopment analysis (DEA) model to measure the ECGI. Then, the influence mechanism of two types of environmental regulation on the ECGI was analyzed. The results show that the ECGI for listed companies in heavily polluting industries is generally low, and the gap between companies is large. Different types of environmental regulations exert heterogeneous effects on the ECGI. Environmental taxes and environmental subsidies have an inverted U-shaped and negative impact on the ECGI respectively, and this impact is particularly significant in non-state-owned enterprises and small-scale enterprises. The mechanism test shows that the environmental tax has a “forcing” effect on the ECGI, which is manifested in the fact that enterprises improve the ECGI through source governance. Environmental subsidies have a “crowding out” effect on the ECGI, which is manifested in the fact that enterprises inhibit the ECGI by increasing the redundancy of green investment.
Performance Models of Data Parallel DAG Workflows for Large Scale Data Analytics
Authors: Shi Juwei , Lu Jiaheng 
Published: October 2022

Abstract
Directed Acyclic Graph (DAG) workflows are widely used for large-scale data analytics in cluster-based distributed computing systems. The performance model for a DAG on data-parallel frameworks (e.g., MapReduce) is a research challenge because the allocation of preemptable system resources among parallel jobs may dynamically vary during execution. This resource allocation variation during execution makes it difficult to accurately estimate the execution time. In this paper, we tackle this challenge by proposing a new cost model, called Bottleneck Oriented Estimation (BOE), to estimate the allocation of preemptable resources by identifying the bottleneck to accurately predict task execution time. For a DAG workflow, we propose a state-based approach to iteratively use the resource allocation property among stages to estimate the overall execution plan. Furthermore, to handle the skewness of various jobs, we refine the model with the order statistics theory to improve estimation accuracy. Extensive experiments were performed to validate these cost models with HiBench and TPC-H workloads. The BOE model outperforms the state-of-the-art models by a factor of five for task execution time estimation. For the refined skew-aware model, the average prediction error is under 3% when estimating the execution time of 51 hybrid analytics (HiBench) and query (TPC-H) DAG workflows.
A modified iterative Method for Solving Split variational Inclusion Problems and Fixed Point Problems for Nonexpansive Semigroup
Authors: Nwawuru Francis 
Published: October 2022

Abstract
In this paper, we introduce and study a modified iterative method for approximating a common solution of split variational inclusion problems and fixed point problems for nonexpansive semigroup in real Hilbert spaces. We prove that the proposed method converges strongly to the solution of the mentioned problem under some mild assuptions. A new inertial extrapolation is introduced which is known to speed up the rate of covergence of iterative algorithms. Our method uses self-adaptive stepsize that is generated at each iteration. It does not depend on the operator norm which is difficult in practice. We give numerical illustrations of the proposed scheme in comparison with others in the literature to further justify the applicability and efficiency of our proposed algorithm.
AMS Subject Classification: 47H09, 47J25.
“Canine First Technique”, An Innovative Approach in Maxillary Impacted Canines: A Case Report
Authors: Bocchino Tecla , Perrotta Stefania , Martina Stefano , D’Antò Vincenzo , Valletta Rosa 
Published: October 2022

Background:
Maxillary canine impaction is one of the most challenging issues in orthodontics. The best treatment protocol in these cases is still debated. The purpose of this study is to describe the management of maxillary canine impaction in an adult female patient with the “Canine First Technique”.

Case Report:
A 21-years-old female attended our dental unit seeking orthodontic treatment. Clinical examination revealed a class II relationship, the persistence of both upper deciduous canines. The panoramic X-ray and Cone Beam Computed Tomography showed bilateral palatal permanent canine displacements and close proximity between crowns of impacted canines and roots of lateral incisors. The canines were disimpacted by means of two cantilevers inserted directly in two Temporary Anchorage Devices placed palatally and when canines were near the crest, the fixed orthodontic treatment was started.

Results:
At the end of the treatment, canine Class I relationships with torque correction of canines, normal overjet and overbite, and good alignment of dental arches were achieved. The radiographic evaluation showed ideal root parallelism and preserved periodontal health in the canine region.

Conclusion:
The Canine First Technique could provide some advantages compared to conventional approaches in terms of biomechanics, esthetics, oral hygiene, and risk reduction of root resorption of upper lateral incisors.
Improving and developing sustainable methods for plant protein processing
Authors:   US Dept. of Agriculture, Liu Keshun 
Published: October 2022

Sustainability is the balance among environment, equity, and economy. We practice it to support ecological, human, and economic health and vitality, and to meet our own needs without compromising the ability of future generations to meet their own needs. With growing world population, widening gap between developed and developing economies, depleting natural resources, and devastating climate change, there is an urgent need for individuals, corporations, and governmental bodies to do more on sustainability. As oil chemists, we can all play important roles by choosing, selecting, and/or developing sustainable methods to process plant proteins into food or feed. Once these methods are adopted or used by others, a ripple effect is created, where an individual effort is transformed into the effort of a large community or even at an industrial level. Although there are many innovative ways to achieve sustainability when oil chemists are at work, reducing uses of chemicals and natural resources (water, energy, etc.) and cost, and generating less or no wastes are the key strategies. In this presentation, I discuss three processing methods I improved, contributed, or developed during last two decades, to illustrate how an individual chemist can contribute to sustainability. The methods to be discussed include a method for making plant-based meat analogs which has been commercialized, a method for producing soft and water-stable aquafeed, which serves as a promising strategy to mitigate water pollution associated with aquaculture, and a low-resource method for making soy protein concentrate, which is being evaluated at Soybean Innovation Lab for fighting malnutrition in Sub-Saharan Africa. Hopefully, we all can make efforts to provide sufficient proteins to all people regardless of their social and economic levels, while maintaining sustainability for benefiting current and future generations.
Conventional and novel technologies for extraction of protein and their impact on structure and functionality as ingredient
Authors:   Iowa State University (ISU), Lamsal Buddhi , Rahman Md Mahfuzur ,   Kraft Heinz Food Company
Published: October 2022

Proteins possess their techno-functionalities by virtues of their state of being, i.e., their molecular makeup and structure, which in turn, is affected by the technologies employed to extract them from the matrices they belong to. This is true for both plant proteins and cell-based proteins. While pH-modulated solubility based aqueous extraction, followed by isolation, is the overwhelming method for plant protein preparations, other technologies, for example dry fractionation (separation based on density, air drag or electrostatic charges), enzyme-, microwave-, ultrasound-, pulsed electric energy- and high pressure-assisted extraction, subcritical water, reverse micelles extraction, and aqueous two-phase systems extraction have been researched for better yields and functionality. Physical separation or dry fractionation preserves the molecular structure and protein possesses better techno-functional and sensory properties than conventional alkaline and acid-based methods. However, dry fractionation can produce only protein concentrate, not isolate. Although alkaline and acid-based methods can prepare to isolate efficiently, subsequent acid precipitation and drying methods form insoluble aggregates and enhance oxidation, which in turn, affect solubility and related functional properties as well as contribute to off-flavor. This presentation will summarize such technologies for extraction, potential for sustainability and their impact on protein's structure and techno-functionalities such as solubility, foaming/emulsion, gelation etc. It will also present authors' recent research on ultrasound-assisted extraction of soy protein and changes in major isolate structure/ function.