bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Wulanmoren Accretionary Complex Unravels Early Devonian to Late Triassic Multiple‐Arc Amalgamation in the Tianshan Orogen (NW China)
Authors: Zhao Tongyang , Xiao Wenjiao , Mao Qigui , Yang He , Abuduxun Nijiati , Li Ping 
Published: December 2022

AbstractReconstructing the tectonic architecture of the southern Altaids is of great importance to piece together the continental growth history of the Central Asian continent. In this paper, we address the subduction‐accretion process of the Paleo‐Tianshan Ocean, one branch of the South Tianshan Ocean, in the southern Altaids, through a detailed geological and geochemical investigation of the Wulanmoren Accretionary Complex (WAC). The WAC is composed of ophiolitic mélanges, ocean plate stratigraphy mélanges, and turbiditic coherent units. In this study, we present key geological, petrological, and geochemical evidence indicating back‐arc and ocean island affinity of the igneous rocks of the WAC. Zircon U‐Pb dates of these rocks ages range between 380.2 ± 1.3 and 302.0 ± 5.3 Ma. The sedimentary matrix units of the mélanges were deposited in the Early Devonian (∼405 Ma) to the Late Triassic (∼222 Ma), rather than Silurian strata as previously thought. However, the ages of some detrital zircons in the sedimentary matrix are Precambrian, pointing to a complex evolution involving multiple ocean island terrains and island arcs of different ages that accreted from the mid‐Paleozoic to the Early Mesozoic.
The Spatial Extent of Magnetopause Magnetic Reconnection From In Situ THEMIS Measurements
Authors: Atz Emil A. , Walsh Brian M. , Broll Jef M. , Zou Ying 
Published: December 2022

AbstractMagnetic reconnection at the magnetopause has long been studied with multi‐spacecraft observations. In this work, data from the five satellite THEMIS mission during the years of 2008–2010 are used to generate statistics regarding the spatial extent of magnetopause reconnection. The presence of a reconnecting magnetopause is determined with the Walén relation as two satellites cross the magnetopause simultaneously. In some cases both satellites measure reconnection whereas in others one satellite measures reconnection and the other does not. This study finds that two spacecraft are more likely to observe a contiguous reconnection region the closer they are spatially, and that reconnection is not always extended around the entire magnetopause. Plasma β gradient drifts are investigated as a cause of local reconnection suppression. Spacecraft position along the magnetopause flanks is also investigated as a possible spatial limitation to reconnection due to changes in shear flow or boundary thickness.
The Time Scale of Shallow Convective Self‐Aggregation in Large‐Eddy Simulations Is Sensitive to Numerics
Authors: Janssens Martin , Vilà‐Guerau de Arellano Jordi , van Heerwaarden Chiel C. , van Stratum Bart J. H. , de Roode Stephan R. , Siebesma A. Pier , Glassmeier Franziska 
Published: December 2022

AbstractNumerical simulations of the tropical mesoscales often exhibit a self‐reinforcing feedback between cumulus convection and shallow circulations, which leads to the self‐aggregation of clouds into large clusters. We investigate whether this basic feedback can be adequately captured by large‐eddy simulations (LESs). To do so, we simulate the non‐precipitating, cumulus‐topped boundary layer of the canonical “BOMEX” case over a range of numerical settings in two models. Since the energetic convective scales underpinning the self‐aggregation are only slightly larger than typical LES grid spacings, aggregation timescales do not converge even at rather high resolutions (<100 m). Therefore, high resolutions or improved sub‐filter scale models may be required to faithfully represent certain forms of trade‐wind mesoscale cloud patterns and self‐aggregating deep convection in large‐eddy and cloud‐resolving models, and to understand their significance relative to other processes that organize the tropical mesoscales.
The Montello Thrust and the Active Mountain Front of the Eastern Southern Alps (Northeast Italy)
Authors: Picotti Vincenzo , Romano Maria Adelaide , Ponza Alessio , Guido Francesco Luigi , Peruzza Laura 
Published: December 2022

AbstractNew field and subsurface data are combined to define the geometry and evolution of the mountain front of the eastern Southern Alps. The Montello thrust (MT), the southernmost frontal structure, is reconstructed by recently published well‐located microseismicity and is connected at depth with the larger Bassano‐Valdobbiadene (BV) thrust. The latter started at 10–9 Ma, whereas the MT evolved at 8–6 Ma, as documented by growing unconformities in the foreland deposits and the nature of the natural gas in the anticline culmination. The latter, named Montello anticline, is growing from the upper Miocene to the Quaternary, as shown by surfaces of abrasion and deposition, including the Biadene windgap. The folded bottom of the windgap is a fan unit recently dated to the MIS 3. The MT is presently creeping and its deformation rates are much lower than previous estimates. Most of the late Miocene to Pleistocene deformation at the front of the eastern Southern Alps is accounted for the BV thrust. The reconstructed average shortening rates are in agreement with the geodetic velocity field from literature. The BV and MT are a unique active thrust system with variable slipping and locked patches, whose interactions should be further studied.
ΔNp63 maintains the fidelity of the myoepithelial cell lineage and directs cell differentiation programs in the murine salivary gland
Authors: Song Eun-Ah Christine , Che Monika , Osinski Jason , Smalley Kirsten , Horeth Erich , Sinha Satrajit , Romano Rose-Anne 
Published: December 2022

AbstractSalivary glands consist of several epithelial cell types of distinct lineages and functional characteristics that are established by directed differentiation programs of resident stem and progenitor cells. We have shown that ΔNp63, a crucial transcriptional regulator of stem/progenitor cells, is enriched in both the basal and myoepithelial cell (MEC) populations and that ΔNp63 positive cells maintain all the descendent epithelial cell lineages of the adult mouse salivary glands (mSGs). Although this pivotal role of ΔNp63 in driving the broader epithelial cell fate and identity in the mSG has been demonstrated, how ΔNp63 functions specifically in the commitment and differentiation of the MEC population is less understood. Using multiple genetic mouse models that allow for cell tracing, we show that ΔNp63 is critical in maintaining and renewing MECs, in part through the transcriptional regulation of Acta2 gene expression, a defining marker of this cell population. We demonstrate that during adult mSG homeostasis, ΔNp63 enriched MECs function as bipotent progenitor cells that maintain not only the MEC population, but also the distinctly different ductal cell lineages. The fidelity of this process is dependent on ΔNp63 expression, since MEC-specific ablation of ΔNp63 results in altered MEC differentiation and affects cellular plasticity resulting in aberrant differentiation of the intercalated ducts and acinar cells. In contrast, we find that the contribution of MECs to ductal and acinar cell regeneration following severe injury is independent of ΔNp63. Our observations offer new insights into cellular mechanisms driving MEC fate choices and differentiation programs in the context of salivary gland homeostasis and in response to injury and regeneration. Long term, these findings have implications for better treatment of salivary gland dysfunction through stem cell-based approaches.
One-pot synthesis of stable antioxidant metal-ornamented polyphenol supramolecular assemblies for material engineering
Authors: Dai Qiong , Shu Tong , Yang Huayan , Su Lei , Li Xiaopeng , Zhang Xueji 
Published: December 2022

AbstractNatural polyphenols (NPPs) are of widespread interest in material engineering; however, only a small fraction of NPPs have been utilized in biomedical applications because of their poor solubility and instability in aqueous conditions. Herein, we report a family of metal-ornamented polyphenol supramolecular (MOPS) assemblies that are highly stable in aqueous solutions for over 6 months. In this one-pot, green synthesis method, metal ions are reduced in water by NPPs to form NPP-capped metal nanoclusters, which then assemble with more NPP molecules to form stable hydrophilic MOPS assemblies. This strategy is generally applicable to a range of NPPs (25 polyphenols tested) regardless of their original water solubility. The resulting stable MOPS assemblies, integrating attributes of both NPPs and metal nanoclusters, possess much stronger antioxidant capabilities than the NPPs, notably a multiplied capacity in superoxide-free radical scavenging capacity. MOPS assemblies can be further engineered, based on polyphenol chemistry, into various functional materials with potential for a wide range of antioxidant applications.
Approaching rehabilitation in patients with advanced glaucoma
Authors: Deemer Ashley D. , Goldstein Judith E. , Ramulu Pradeep Y. 
Published: December 2022

AbstractVision loss from advanced glaucoma is currently irreversible and impairs functional visual ability to effectively perform everyday tasks in a number of distinct functional domains. Vision rehabilitation strategies have been demonstrated to be effective in low vision populations and should be utilized in persons with advanced glaucoma to reduce disability and improve quality of life. Initial challenges to rehabilitation include an incomplete understanding of vision rehabilitation by the physician and patient, motivation to integrate rehabilitation into the plan of care, and availability of suitable providers to deliver this care. Physicians, working with well-trained vision rehabilitation providers can maximize function in important visual domains customized to the patient based on their needs, specific complaints, severity/pattern of visual damage, and comorbidities. Potential rehabilitative strategies to be considered for reading impairment include spectacle correction, visual assistive equipment, and sensory substitution, while potential strategies to facilitate driving in those deemed safe to do so include refractive correction, lens design, building confidence, restriction of driving to safer conditions, and avoiding situations where cognitive load is high. Mobility is frequently disrupted in advanced glaucoma, and can be addressed through careful distance refraction, behavior modification, home modification, mobility aids, walking assistance (i.e., sighted guide techniques), and smartphone/wearable technologies. Visual motor complaints are best addressed through optimization of lighting/contrast, sensory substitution, IADL training, and education. Special rehabilitative concerns may arise in children, where plans must be coordinated with schools, and working adults, where patients should be aware of their rights to accommodations to facilitate specific job tasks.
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma
Authors: Taylor Chelsea A. , Watson Robert A. , Tong Orion , Ye Weiyu , Nassiri Isar , Gilchrist James J. , de los Aires Alba Verge , Sharma Piyush Kumar , Koturan Surya , Cooper Rosalin A. , Woodcock Victoria K. , Jungkurth Elsita , Shine Brian , Coupe Nicholas , Payne Miranda J. , Church David N. , Naranbhai Vivek , Groha Stefan , Emery Paul , Mankia Kulveer , Freedman Matthew L. , Choueiri Toni K. , Middleton Mark R. , Gusev Alexander , Fairfax Benjamin P. 
Published: December 2022

AbstractTreatment with immune checkpoint blockade (ICB) frequently triggers immune-related adverse events (irAEs), causing considerable morbidity. In 214 patients receiving ICB for melanoma, we observed increased severe irAE risk in minor allele carriers of rs16906115, intronic to IL7. We found that rs16906115 forms a B cell-specific expression quantitative trait locus (eQTL) to IL7 in patients. Patients carrying the risk allele demonstrate increased pre-treatment B cell IL7 expression, which independently associates with irAE risk, divergent immunoglobulin expression and more B cell receptor mutations. Consistent with the role of IL-7 in T cell development, risk allele carriers have distinct ICB-induced CD8+ T cell subset responses, skewing of T cell clonality and greater proportional repertoire occupancy by large clones. Finally, analysis of TCGA data suggests that risk allele carriers independently have improved melanoma survival. These observations highlight key roles for B cells and IL-7 in both ICB response and toxicity and clinical outcomes in melanoma.
Thermal physiology integrated species distribution model predicts profound habitat fragmentation for estuarine fish with ocean warming
Authors: Harishchandra Akila , Xue Huijie , Salinas Santiago , Jayasundara Nishad 
Published: December 2022

AbstractSpecies distribution models predict a poleward migration for marine ectotherms with ocean warming. However, a key limitation in current species distribution models (SDM) is that they do not account for population-specific heterogeneity in physiological responses to temperature change resulting from local adaptations and acclimatization. To address this gap, we developed a novel, Physiology Integrated BioClimate Model (PIBCM) that combines habitat-specific metabolic thermal physiological tolerance of a species into a bioclimate envelope model. Using a downscaling approach, we also established a fine-resolution coastal sea-surface temperature data set for 2050–2080, that showed a high degree of location-specific variability in future thermal regimes. Combining predicted temperature data with the PIBCM model, we estimated habitat distribution for a highly eurythermal intertidal minnow, the Atlantic killifish (Fundulus heteroclitus), a species that likely presents a best-case-scenario for coastal vertebrates. We show that the killifish northern boundary shifts southwards, while distinct habitat fragmentation occurs in the southern sub-population (due to migration of adjacent fish populations to the nearest metabolically optimal thermal habitat). When compared to current SDMs (e.g., AquaMaps), our results emphasize the need for thermal physiology integrated range shift models and indicate that habitat fragmentation for coastal fishes may reshape nursery habitats for many commercially and ecologically important species.
Feature fusion based VGGFusionNet model to detect COVID-19 patients utilizing computed tomography scan images
Authors: Uddin Khandaker Mohammad Mohi , Dey Samrat Kumar , Babu Hafiz Md. Hasan , Mostafiz Rafid , Uddin Shahadat , Shoombuatong Watshara , Moni Mohammad Ali 
Published: December 2022

AbstractCOVID-19 is one of the most life-threatening and dangerous diseases caused by the novel Coronavirus, which has already afflicted a larger human community worldwide. This pandemic disease recovery is possible if detected in the early stage. We proposed an automated deep learning approach from Computed Tomography (CT) scan images to detect COVID-19 positive patients by following a four-phase paradigm for COVID-19 detection: preprocess the CT scan images; remove noise from test image by using anisotropic diffusion techniques; make a different segment for the preprocessed images; and train and test COVID-19 detection using Convolutional Neural Network (CNN) models. This study employed well-known pre-trained models, including AlexNet, ResNet50, VGG16 and VGG19 to evaluate experiments. 80% of images are used to train the network in the detection process, while the remaining 20% are used to test it. The result of the experiment evaluation confirmed that the VGG19 pre-trained CNN model achieved better accuracy (98.06%). We used 4861 real-life COVID-19 CT images for experiment purposes, including 3068 positive and 1793 negative images. These images were acquired from a hospital in Sao Paulo, Brazil and two other different data sources. Our proposed method revealed very high accuracy and, therefore, can be used as an assistant to help professionals detect COVID-19 patients accurately.
A novel optimization algorithm for enabling dynamically collimated proton arc therapy
Authors: Smith Blake R. , Flynn Ryan T. , Hyer Daniel E. 
Published: December 2022

AbstractThe advent of energy-specific collimation in pencil beam scanning (PBS) proton therapy has led to an improved lateral dose conformity for a variety of treatment sites, resulting in better healthy tissue sparing. Arc PBS delivery has also been proposed to enhance high-dose conformity about the intended target, reduce skin toxicity, and improve plan robustness. The goal of this work was to determine if the combination of proton arc and energy-specific collimation can generate better dose distributions as a logical next step to maximize the dosimetric advantages of proton therapy. Plans were optimized using a novel DyNamically collimated proton Arc (DNA) genetic optimization algorithm that was designed specifically for the application of proton arc therapy. A treatment planning comparison study was performed by generating an uncollimated two-field intensity modulated proton therapy and partial arc treatments and then replanning these treatments using energy-specific collimation as delivered by a dynamic collimation system, which is a novel collimation technology for PBS. As such, we refer to this novel treatment paradigm as Dynamically Collimated Proton Arc Therapy (DC-PAT). Arc deliveries achieved a superior target conformity and improved organ at risk (OAR) sparing relative to their two-field counterparts at the cost of an increase to the low-dose, high-volume region of the healthy brain. The incorporation of DC-PAT using the DNA optimizer was shown to further improve the tumor dose conformity. When compared to the uncollimated proton arc treatments, the mean dose to the 10mm of surrounding healthy tissue was reduced by 11.4% with the addition of collimation without meaningfully affecting the maximum skin dose (less than 1% change) relative to a multi-field treatment. In this case study, DC-PAT could better spare specific OARs while maintaining better target coverage compared to uncollimated proton arc treatments. While this work presents a proof-of-concept integration of two emerging technologies, the results are promising and suggest that the addition of these two techniques can lead to superior treatment plans warranting further development.
Risk factors for the development of idiopathic macular hole: a nationwide population-based cohort study
Authors: Hwang Sungsoon , Kang Se Woong , Kim Sang Jin , Choi Jaehwan , Son Ki Young , Lim Dong Hui , Shin Dong Wook , Choi DooSeok , Chang Yoosoo , Ryu Seungho , Cho Juhee 
Published: December 2022

AbstractThis nationwide population-based cohort study searched for demographic, comorbid, behavioral, and reproductive risk factors for idiopathic macular hole (MH) development using data provided by the Korean National Health Insurance Service. A total of 4,496,867 individuals aged 50–79 years who participated in the Korean National Health Screening Program in 2013 or 2014 were included. Participants were followed up until December 2018, and incident cases of idiopathic MH were identified. Prospective associations between incident idiopathic MH and various covariates were investigated using multivariable-adjusted Cox proportional hazard models. During an average follow-up period of 4.91 years, 3054 patients were newly diagnosed with idiopathic MHs. Women showed greater risk (hazard ratio of 1.71) and earlier presentation of idiopathic MH than men. Compared to the normal body mass index group, the obese group (≥ 25 kg/m2) showed a significantly lower risk of idiopathic MH. Among postmenopausal women, those with two or more children showed a greater risk of idiopathic MH than those who had not been pregnant, with a hazard ratio of 1.80. In conclusion, idiopathic MH occurred earlier and greater in women. Childbirth were associated with an increased risk of MH development, and obesity was associated with a lower risk of MH.
Reclassification of eight Akkermansia muciniphila strains and description of Akkermansia massiliensis sp. nov. and Candidatus Akkermansia timonensis, isolated from human feces
Authors: Ndongo Sokhna , Armstrong Nicholas , Raoult Didier , Fournier Pierre-Edouard 
Published: December 2022

AbstractAkkermansiamuciniphila is a human intestinal tract bacterium that plays an important role in the mucus layer renewal. Several studies have demonstrated that it is a modulator for gut homeostasis and a probiotic for human health. The Akkermansia genus contains two species with standing in nomenclature but their genomic diversity remains unclear. In this study, eight new Akkermansia sp. strains were isolated from the human gut. Using the digital DNA-DNA hybridization (dDDH), average nucleotide identity (ANI) and core genome-based phylogenetic analysis applied to 104 A.muciniphila whole genomes sequences, strains were reclassified into three clusters. Cluster I groups A.muciniphila strains (including strain ATCC BAA-835T as type strain), whereas clusters II and III represent two new species. A member of cluster II, strain Marseille-P6666 differed from A.muciniphila strain ATCC BAA-835T and from A.glycaniphila strain PytT in its ability to grow in microaerophilic atmosphere up to 42 °C, to assimilate various carbon sources and to produce acids from a several compounds. The major fatty acids of strain Marseille-P6666 were 12-methyl-tetradecanoic and pentadecanoic acids. The DNA G + C content of strain Marseille-P6666 was 57.8%. On the basis of these properties, we propose the name A.massiliensis sp. nov. for members of cluster II, with strain Marseille-P6666T (= CSUR P6666 = CECT 30548) as type strain. We also propose the name “Candidatus Akkermansia timonensis” sp. nov. for the members of cluster III, which contains only uncultivated strains, strain Akk0196 being the type strain.
Exploiting Sentinel-2 dataset to assess flow intermittency in non-perennial rivers
Authors: Cavallo Carmela , Papa Maria Nicolina , Negro Giovanni , Gargiulo Massimiliano , Ruello Giuseppe , Vezza Paolo 
Published: December 2022

AbstractKnowledge about the frequency and duration of each flowing status of non-perennial rivers is severely limited by the small number of streamflow gauges and reliable prediction of surface water presence by hydrological models. In this study, multispectral Sentinel-2 images were used to detect and monitor changes in water surface presence along three non-perennial Mediterranean rivers located in southern Italy. Examining the reflectance values of water, sediment and vegetation covers, the bands in which these classes are most differentiated were identified. It emerged that the false-color composition of the Sentinel-2 bands SWIR, NIR and RED allows water surfaces to be clearly distinguished from the other components of the river corridor. From the false-color composite images, it was possible to identify the three distinct flowing status of non-perennial rivers: “flowing” (F), “ponding” (P) and “dry” (D). The results were compared with field data and very high-resolution images. The flowing status was identified for all archive images not affected by cloud cover. The obtained dataset allowed to train Random Forest (RF) models able to fill temporal gaps between satellite images, and predict the occurrence of one of the three flowing status (F/P/D) on a daily scale. The most important predictors of the RF models were the cumulative rainfall and air temperature data before the date of satellite image acquisition. The performances of RF models were very high, with total accuracy of 0.82–0.97 and true skill statistic of 0.64–0.95. The annual non-flowing period (phases P and D) of the monitored rivers was assessed in range 5 to 192 days depending on the river reach. Due to the easy-to-use algorithm and the global, freely available satellite imagery, this innovative technique has large application potential to describe flowing status of non-perennial rivers and estimate frequency and duration of surface water presence.