bluuebunny/crossref_metadata_2025_split huggingface dataset:
Midline Mandibulotomy Approach for Oral Cavity and Oropharynx Tumors: Long-Term Experience in a Single Institution
Authors: López-Arcas José M , Vadillo Juan Manuel , Castillo José L Del , Lara Patricia A , Cebrián José L. , Ruiz-Sánchez Beatriz , Aragoneses Juan M. 
Published: January 2022

Abstract
Purpose: To describe our clinical experience with the use of the midline mandibulotomy approach for oral cavity and oropharynx tumors.Methods: Charts were reviewed retrospectively for 67 consecutive patients who underwent mandibulotomies over a 15-year period (2002-2017) as part of their treatment for oral and oropharyngeal malignancies, with an average follow-up of 57.7 months.Results: Sixty-seven patients underwent a mandibulotomy. There were 59 males (88%) with a mean age of 56.9 years and eight females (12%) with a mean age 56.5 years. The approach was a midline mandibulotomy in 50 patients (74.6%), a paramedian mandibulotomy in 10 patients (14.9%), and a posterior mandibulotomy in seven (10.44%: angle 1 (1.5%), body 5 (7.5%), and ramus 1 (1.5%).In the group of patients undergoing median or paramedian mandibulotomies, adequate exposure of the lesion was achieved in all cases with a significant lower rate of complications (13,4%) (p<0.005) compared to the posterior mandibulotomy group (37,5%) .Conclusions: The results of the study confirm that the anterior mandibulotomy approach provides excellent exposure for oral and oropharyngeal tumors, with a significant lower complication rate compared to the posterior mandibulotomy approach.Until minimally invasive Robotic technology is not widespread, conventional techniques such as midline mandibulotomy approaches, with “modern-times” refinements still have their place in head and neck oncology surgery
Discussing Anthropogenic Global Warming from an Econometric Perspective: A Change in Forecasting Based on the ARIMA Paleoclimate Time Series Model
Authors: Santos Gilmar Veriato Fluzer , Cordeiro Lucas Gamalel , Rojo Claudio Antonio , Leismann Edison Luiz 
Published: January 2022

Abstract
Global warming has divided the scientific community worldwide with predominance for anthropogenic alarmism. This article aims to project a climate change scenario using a stochastic model of paleotemperature time series and compare it with the dominant thesis. The ARIMA model – an integrated autoregressive process of moving averages, known as Box-Jenkins - was used for this purpose. The results showed that the estimates of the model parameters were below 1°C for a scenario of 100 years which suggests a period of temperature reduction and a probable cooling, contrary to the prediction of the IPCC and the anthropogenic current of an increase in 1.50° C to 2.0° C by the end of this century. Thus, we hope with this study to contribute to the discussion by adding a statistical element of paleoclimate in counterpoint to the current consensus and to placing the debate in a long-term historical dimension, in line with other research present in climate sciences and statistics.
Neonatal Outcomes In Women With Preterm Premature Rupture of Membranes At Periviable Gestational Age
Authors: Herzlich Jacky , Mangel Laurence , Halperin Ariel , Lubin Daniel , Marom Ronella 
Published: January 2022

Abstract
Purpose: To examine the outcomes of preterm infants born to women with preterm premature rupture of membranes at periviable gestational age.Methods: This is a retrospective study analyzing data on singleton deliveries complicated by prolonged premature rupture of membranes occurring before 24 weeks of gestation. Neonatal outcomes including birth weight, Apgar score, retinopathy of prematurity, intraventricular hemorrhage, bronchopulmonary dysplasia, necrotizing enterocolitis, hearing impairment and mortality were evaluated.Results: Ninety four preterm infants who were born after a prolonged premature rupture of membranes of at least 7 days were included in the study.Median gestational week at onset of membrane rupture was 27.1 ± 4.2 weeks (range 17 - 33) and median latency period in days was 16 ± 21.8 (range 7 - 105). We found that the survival rate to discharge within neonates born after prolonged rupture of membrane at gestational week less than 24 weeks is 79.2%. These neonates did not show an increased rate of major morbidities compared to neonates born following membrane rupture at gestational week 24 to 27. Conclusion: We described a high survival rate without major morbidities following prolonged preterm membrane rupture before viability.
Ferroptosis-Related Long Non-coding RNA Predicts Prognosis Model of Hepatocellular Carcinoma
Authors: Zhang Congyue , Zhang Chaoqun , Zhou Huifang , Hu Zhankai , Sun Dianxing 
Published: January 2022

Abstract
Background: Hepatocellular carcinoma (HCC) is the most common malignancy globally, and ferroptosis is an iron-dependent cell death process. Furthermore, aberrant expression of long non-coding RNAs (lncRNAs) driving HCC development and progression has increased attention. Materials and Methods: We collected lncRNA expression profiles associated with ferroptosis from The Cancer Genome Atlas (TCGA) and FerrDb databases and clinicopathological and overall survival (OS) information to determine the association between ferroptosis-related lncRNAs(FRlncRNAs) and survival of HCC patients by co-expression analysis. A prognostic lncRNA model of 22 differentially expressed lncRNAs was constructed using Cox regression analysis and the LASSO algorithm. Kaplan-Meier analysis revealed that a high-risk lncRNAs profile was associated with poor prognosis in HCC. Our risk assessment model outperformed conventional clinical data in predicting the prognosis of HCC. Result: GSEA revealed immune and tumor-related pathways in individuals in the high- and low-risk groups. In addition, TCGA showed that T cell functions, including B cells, Cytolytic, macrophages, MHC-class-I, mast cells, neutrophils, NK cells, helper T cells, Type-I-IFN, and Type-II-IFN, were significantly different between high and low-risk groups. Immune checkpoints such as TNFSF18, IDO2, CD276, NRP1, and TNFSF4 were also differentially expressed between the two risk groups. Conclusions: Our findings provide a robust prognostic and immune response prediction model for HCC patients based on lncRNAs associated with ferroptosis.
Individualized Folic Acid Supplementation based on Polymorphisms of Methylenetetrahydrofolate Reductase (MTHFR) and Methionine Synthase Reductase (MTRR), Compared with Traditional Folic Acid Supplementation, Reduces Gestational Diabetes Mellitus
Authors: Yu Xiaoying , Diao Le , Du Baoying , Wang Ying , Xv Xiaoqin , Yu Anqi , Zhao Jiangman 
Published: January 2022

Abstract
Backgroud: Folic Acid (FA) may contribute to the development of gestational diabetes mellitus (GDM), but existing studies are inconsistent. We examined the genotype distributions and allele frequencies of methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase reductase (MTRR) A66G polymorphisms of pregnant women in China, and compared the effects of individualized folate supplementation and traditional FA supplementation on GDM.Methods: The genotype distributions and allele frequencies of MTHFR C677T, A1298C and MTRR A66G polymorphisms in 968 pregnant women (case group) were tested. FA metabolism was ranked at four levels, and then pregnant women of different levels are supplemented with different doses of FA at different periods. The case group was followed up for pregnancy complications and compared with 1,940 pregnant women traditionally supplemented with FA in the same hospital (control group).Results: The allele frequencies of MTHFR C677T were 63.3% (C) and 36.7% (T), those of MTHFR A1298C were 79.3% (A) and 20.7% (C), and those of MTRR A66G were 75.0% (A) and 25.0% (G). Compared with control group, the incidence of GDM in the case group were significantly lower, especially in high-risk pregnant women after FA supplementation.Conclusion: Traditional FA supplementation based on personal habits is controversial, but the use of polymorphisms of genes to clarify the FA metabolism of pregnant women, appropriate, timely and accurate supplementation of FA can effectively reduce gestational diabetes, especially for high-risk pregnant women.
Predictors of Nursing Home Admission in the Older Population in Belgium
Authors: Berete Finaba , Demarest Stefaan , Charafeddine Rana , Ridder Karin , Vanoverloop Johan , Oyen Herman , Bruyère Olivier , Heyden Johan 
Published: January 2022

Abstract
BackgroundThis study examines the risk factors associated with nursing home admission (NHA) in Belgium to contribute to a better planning of the future demand for nursing home (NH) services and health care resources.MethodsIndividual level linkage of the 2013 Belgian health interview survey data and health insurance data (2012 to 2018) was done. Only non-institutionalized participants, aged ≥65 years at the time of the survey were included in this study (n=1930). Participants were followed until NHA, death or end of study period, i.e., December 31, 2018. The risk of NHA was calculated using a competing risk analysis.ResultsOver the follow-up period (median 5.29 years), 226 individuals were admitted to a NH and 268 died without admission to a NH. The overall cumulative risk of NHA was 1.4%, 5.7% and 13.1% at, respectively 1 year, 3 years and the end of follow-up. After multivariable adjustment, higher age, low educational attainment, belonging to low income household, living alone, use of home care services and a number of need factor (e.g., history of falls, suffering from urinary incontinence, depression or Alzheimer disease, etc.) were significantly associated with a higher risk of NHA, while female, individuals with multimorbidity and increased contacts with health care providers were significantly associated with a decreased risk of NHA. Subjective health and limitations are both significant determinants of NHA, but subjective health is an effect modifier on the effect of limitations and vice versa.ConclusionsOur findings pinpoint important predictors of NHA in older adults, and offer possibilities of prevention to avoid or delay NHA for this population. The strong impact of need factors on the risk of NHA may indicate equitable access to NHA (i.e., those in need for support have access to NH). Practical implications include prevention of falls and appropriate and timely management of physical chronic conditions and neurodegenerative disorders. Focus should also be on people living alone to provide the appropriate social support and/or home care services. Further investigation of predictors of NHA should include contextual factors such as the availability of nursing-home beds, hospital beds, physicians and waiting lists for NHA.
Comparison of MR Perfusion and FDG-PET Brain Studies in Patients With Alzheimer’s Disease and Amnestic Mild Cognitive Impairment
Authors: Wabik Aleksandra , Trypka Elżbieta , Bladowska Joanna , Statkiewicz Mikołaj , Sąsiadek Marek , Zimny Anna 
Published: January 2022

Abstract
Background: The aim of this study was to compare Dynamic Susceptibility Contrast Enhanced MRI (DSC-MRI) and PET with flurodeoxyglucose (FDG-PET) in the diagnosis of Alzheimer’s Disease (AD) and amnestic Mild Cognitive Impairment (aMCI).Methods: Age and sex matched 27 patients with AD, 39 with aMCI and 16 controls underwent brain DSC-MRI followed by FDG-PET. Values of relative Cerebral Blood Volume (rCBV) and rCBV z-scores from frontal, temporal, parietal and PCG cortices were correlated with the rate of glucose metabolism from PET. Sensitivity, specificity and accuracy of DSC-MRI and FDG-PET in the diagnosis of AD and aMCI were assessed and compared.Results: In AD hypoperfusion was found within all examined locations, while in aMCI in both parietal and temporal cortices and left PCG. FDG-PET showed the greatest hypometabolism in parietal, temporal and left PCG regions in both AD and aMCI. FDG-PET was more accurate in distinguishing aMCI from controls than DSC-MRI. In AD and combined group (AD + aMCI ) there were numerous correlations between DSC-MRI and FDG-PET results. Conclusions: In AD the patterns of hypoperfusion and glucose hypometabolism are similar thus DSC-MRI may be a competitive method to FDG-PET. FDG-PET is a more accurate method in the diagnosis of aMCI.
Enhancing Intelligent Anemia Detection via Unifying Global and Local Views of Conjunctiva Image with Two-Branch Neural Networks
Authors: Zheng Lijuan , Liu Shaopeng , Tian Senping , Guo Jianhua , Wang Xinpeng , Liao Xiuxiu , Hong Jiaming 
Published: January 2022

Abstract
Anemia is one of the most widespread clinical symptoms all over the world, which could bring adverse effects on people's daily life and work. Considering the universality of anemia detection and the inconvenience of traditional blood testing methods, many deep learning detection methods based on image recognition have been developed in recent years, including the methods of anemia detection with individuals’ images of conjunctiva. However, existing methods using one single conjunctiva image could not reach comparable accuracy in anemia detection in many real-world application scenarios. To enhance intelligent anemia detection using conjunctiva images, we proposed a new algorithmic framework which could make full use of the data information contained in the image. To be concrete, we proposed to fully explore the global and local information in the image, and adopted a two-branch neural network architecture to unify the information of these two aspects. Compared with the existing methods, our method can fully explore the information contained in a single conjunctiva image and achieve more reliable anemia detection effect. Compared with other existing methods, the experimental results verified the effectiveness of the new algorithm.
Effects of Lockdowns And Its Impacts On Age-Specific Transmission Dynamics of SARS-Cov-2 In Georgia, USA
Authors: Lau Max SY , Liu Carol , Siegler Aaron , Sullivan Patrick , Waller Lance A. , Shioda Kayoko , Lopman Benjamin 
Published: January 2022

Abstract
Social distancing measures are effective in reducing overall community transmission but much remains unknown about how they have impacted finer-scale dynamics. In particular, much is unknown about how changes of contact patterns and other behaviors including adherence to social distancing, induced by these measures, may have impacted finer-scale transmission dynamics among different age groups. In this paper, we build a stochastic age-specific transmission model to systematically characterize the degree and variation of age-specific transmission dynamics, before and after lifting the lockdown in Georgia, USA. We perform Bayesian (missing-) data-augmentation model inference, leveraging reported age-specific case, seroprevalence and mortality data. We estimate that community-level transmissibility was reduced to 41.2% with 95% CI [39%, 43.8%] of the pre-lockdown level in about a week of the announcement of the shelter-in-place order. Although it subsequently increased after the lockdown was lifted, it only bounced back to 62% [58%, 67.2%] of the pre-lockdown level after about a month. We also find that during the lockdown susceptibility to infection increases with age. Specifically, relative to the oldest age group (>65+), susceptibility for the youngest age group (0-17 years) is 0.13 [0.09, 0.18], and it increases to 0.53 [0.49, 0.59] for 18-44 and 0.75 [0.68, 0.82] for 45- 64. More importantly, our results reveal clear changes of age-specific susceptibility (defined as average risk of getting infected during an infectious contact incorporating age-dependent behavioral factors) after the lockdown was lifted, with a trend largely consistent with reported age-specific adherence levels to social distancing and preventive measures. Specifically, the older groups (>45) (with the highest levels of adherence) appear to have the most significant reductions of susceptibility (e.g., post-lockdown susceptibility reduced to 31.6% [29.3%, 34%] of the estimate before lifting the lockdown for the 65+ group). Finally, we find heterogeneity in case reporting rates among different age groups, with the lowest rate occurring among the 0-18 group (9.7% [6.4%, 19%]). Our results provide a more fundamental understanding of the impacts of stringent lockdown measures, and finer evidence that other social distancing and preventive measures may be effective in reducing SARS-CoV-2 transmission. These results may be exploited to guide more effective implementations of these measures in many current settings (with low vaccination rate globally and emerging variants) and in future potential outbreaks of novel pathogens.
Pain Characteristics Among Individuals with Duchenne Muscular Dystrophy According to Their Clinical Stage
Authors: Kim Aram , Park Mina , Shin Hyung-Ik 
Published: January 2022

Abstract
Background: Assessment of pain is not routine, standardized, or well-understood in individuals with Duchenne muscular dystrophy (DMD), even though pain is a common problem reported by more than half of DMD patients. Previous studies in this area included multiple neuromuscular diseases with highly variable phenotypes. Therefore, our aim was to focus on DMD specifically and evaluate comprehensive pain characteristics according to the disease stages, from ambulatory to late non-ambulatory. Methods: This was a cross-sectional study conducted in an out-patient pediatric rehabilitation clinic. Participants were 148 males with confirmed DMD, 14.5±5.3 years of age. Face-to-face interviews were conducted using a structured questionnaire regarding pain frequency, duration, intensity, location, aggravating/relieving factors, pain interference (Brief Pain Inventory), pain quality (PainDETECT Questionnaire), and functional ability (DMD Functional Ability Self-Assessment Tool). Pain characteristics were analyzed according to the clinical stage: ambulatory (Amb), early non-ambulatory (ENA), and late non-ambulatory (LNA).Results: Of the 148 participants who completed the assessment, 66 (44.6%) reported pain during the previous 4 weeks. There were no differences in the pain duration or intensity among the three groups. Pain location (Amb: calf, ENA: knee, LNA: lumbosacral region), aggravating factor (Amb: ambulation, ENA: transfer, LNA: sitting), and relieving factor (Amb: rest and massage, ENA and LNA: positional change) differed according to the clinical stage. Individuals in the LNA stage reported an increase in the frequency of pain and number of pain sites. The effect of pain on mood was also found to be greater in the LNA group than in the other clinical stages. Conclusion: Pain characteristics including location, aggravating/relieving factors, pain frequency, and pain interference change as the disease progresses in patients with DMD. Clinicians could more efficiently and critically assess and manage the patients’ pain aspect, based on these findings.
Mathematical Analysis of Supply Chain Optimization focusing on Artificial Neural Network: A case study in Apparel Manufacturing Organization
Authors: Ahmad Shibbir , Kamruzzaman Mohammad 
Published: January 2022

Abstract
In this study, implemented artificial nueral network (Ann) in apparel manufacturing organizations to optimize the supply chain converging on right supplier selection by analyzing their performance criteria.Moreover, data collected from three diffrents factory to analyze the efficiney and profit -loss status of that units. Furthermore, analyze the supplier selection criteria of three suppliers in order to select the right supplier at the real time in apparel manufacturing industry . This study shows that it can be saved 20 % of the total cost.
PPAR-γ Promotes the Polarization of Rat Retinal Microglia To M2 Phenotype By Regulating the Expression of CD200-CD200R1 Under Hypoxia
Authors: Hong Yiyi , Jiang Li , Huang Wei , Deng Wen , Tang Fen , Shen Chaolan , Lan Qianqian , Huang Hui , Zhong Haibin , Lv Jian , Zeng Siming , Peng Biyan , Ouyang Yiqiang , Liang Jinning , Mo Zhongxiang , Chen Qi , Cui Ling , Zhang Mingyuan , Zhou Zhou , Chen Changzheng , Li Min , Xu Fan 
Published: January 2022

Abstract
Objective
Based on recent reports, peroxisome proliferator-activated receptor-γ (PPAR-γ) could promote microglial M2 polarization to inhibit inflammation. However, the specific molecular mechanisms instigate the anti-inflammatory ability of PPAR-γ in microglia have not been expounded. In the present study, we explored the molecular mechanisms of the anti-inflammatory effects of PPAR-γ in hypoxia-stimulated rat microglial cells.
Methods
shRNA expressing lentivirus was used to knock down PPAR-γ and CD200 genes. The hypoxia-induced polarization markers release (M1: iNOS, IL-1β, IL-6 and TNF-α; M2: Arg-1, YM1, IL-4 and IL-10) was assessed by RT-PCR, while PPAR-γ-related signals (PPAR-γ, PPAR-γ in cytoplasm or nucleus, CD200 and CD200Rs) were monitored by western blot and RT-PCR.
Results
Hypoxia enhanced PPAR-γ and CD200 expressions in microglial cells. In addition, PPAR-γ agonist 15d-PGJ2 elevated CD200 and CD200R1 expressions, while sh-PPAR-γ (PPAR-γ knock-down) had just the opposite effect. Following hypoxia, expressions of M1 markers increased significantly, while those of M2 markers decreased, and the above effects were attenuated by 15d-PGJ2. Conversely, knocking down PPAR-γ or CD200 inhibited the polarization of microglial cells to M2 phenotype.
Conclusion
Results demonstrated that PPAR-γ performed an anti-inflammatory function in hypoxia-stimulated microglial cells by promoting their polarization to M2 phenotype via CD200-CD200R1 pathway.
Manual Compression Versus MANTA Device for Access Management After Impella Removal on the ICU
Authors: Cuculi Florim , Burkart Philipp , Cioffi Giacomo , Moccetti Federico , Madanchi Mehdi , Seiler Thomas , Hess Stefanie , Wolfrum Mathias , Jeyarasa Magiliny , Meier Sonja , Kuzmiakova Silvia , Hakimi Maani , Seelos Robert , Kobza Richard , Toggweiler Stefan , Attinger Adrian , Bossard Matthias 
Published: January 2022

Abstract
Objective: To compare the safety and efficacy of manual compression versus use of the MANTA® closure device for access management after Impella® removal on the intensive care unit (ICU).Background: The number of patients treated with percutaneous left ventricular assist devices (pLVAD), namely Impella® and ECMO, for complex cardiac procedures or shock, is growing. However, removal of pLVAD and large bore arteriotomy closure among such patients on the ICU remains challenging, since it is associated with a high risk for bleeding and vascular complications. Methods: Patients included in a prospective registry between 2017 and 2020 were analyzed. Bleeding and vascular access site complications were assessed and adjudicated according to VARC-2 criteria. Results: We analyzed a cohort of 87 consecutive patients, who underwent access closure after Impella® removal on ICU by using either the MANTA® device or manual compression. The cohort´s mean age was 66.1±10.7 years and 76 patients (87%) were recovering from CS. Mean support time was 40 hours (Interquartile range 24–69 hours). MANTA® was used in 31 patients (35.6%) and manual compression was applied in 56 patients (64.4%). Overall access related bleedings were significantly lower in the MANTA® group (6.5% versus 39.3%(odds ratio (OR) 0.10, 95% CI 0.01–0.50; p=0.001), and there was no significant difference in vascular complications between the two groups(p=0.55).Conclusions: Our data suggests that the application of the MANTA® device directly on the ICU is safe. In addition, it seems to reduce access related bleeding without increasing the risk of vascular complications.