bluuebunny/crossref_metadata_2025_split huggingface dataset:
ГОТОВНІСТЬ МАЙБУТНІХ ВИХОВАТЕЛІВ ДО ФОРМУВАННЯ ЕКОЛОГІЧНО ДОЦІЛЬНОЇ ПОВЕДІНКИ У ДІТЕЙ ДОШКІЛЬНОГО ВІКУ ЯК РЕЗУЛЬТАТ ФАХОВОЇ ПІДГОТОВКИ
Authors: Іванчук С. А. 
Published: January 2022

Параметри результативності (ефективності) професійної підготовки майбутніх вихователів закладів дошкільної освіти презентовано у різних вимірах. У статті означено феноменологію еколого-професійної та еколого-педагогічної компетентності. Проаналізовано екологічну домінанту у професійній підготовці майбутніх вихователів закладів дошкільної освіти.
Визначено новий підхід до підготовки фахівців дошкільної освіти – лідерської діяльності педагога в екологічній освіті дошкільників, яка представляє цілісну модель, що включає мотиваційно-ціннісну, емоційно-вольову, змістову та діяльнісну підструктури та критерії до них.
Окреслені ключові атрибути та екологічні домінанти у професійній підготовки майбутнього фахівця дошкільної освіти до здійснення еколого-педагогічної діяльності.
Акцентовано увагу на таких поняттях, як екологічна культура, соціально-екологічна компетентність, еколого-педагогічна компетентність майбутніх вихователів, еколого-педагогічна готовність, професіоналізм вихователів дошкільних закладів у формуванні екологічно доцільної поведінки дошкільників, готовності майбутніх вихователів до формування в старших дошкільників навичок, орієнтованих на сталий розвиток.
Подано власне ставлення до розуміння «готовність до формування екологічно доцільної поведінки дітей дошкільного віку» – професійно-особистісне цілісне інтегративне новоутворення, яке характеризується наявністю сформованих (привласнених) мотиваційно-ціннісних диспозицій, когнітивно-інтелектуальних характеристик, поведінкових патернів і рефлексивно-оцінних дій, що розкриваються у здатності суб’єкта професійної діяльності до ефективного формування означеного сегменту життєдіяльності дошкільників.
Evaluation of the ethanolic extract of Myconia albicas (Old Cinnamon) in the alternative model of anxiety in zebrafish
Authors: Castro Fernanda Mota de , Alexandre Aimê Veras , Batista Francisco Lucas Alves , Santos Sacha Aubrey Alves Rodrigues , Mendes Francisco Rogênio da Silva , Monteiro Moreira Ana Cristina de Oliveira , Magalhães Francisco Ernani Alves , Honório Júnior José Eduardo Ribeiro , Camposa Adriana Rolim 
Published: January 2022

Myconia albicans is the most abundant genus of the melastomaceous botanical family. In Brazil, it is known as "Canela de Velho", and is used mainly in inflammatory processes. Due to the scarcity of scientific works that report its pharmacological effect, the objective of this study was to perform its chemical characterization, toxicity, and the possible effect on the nervous system, using the experimental model Zebrafish (Dario regio). The organic extract of ethyl acetate (EtOAc) was elaborated through the dry leaves of the cinnamon tree of old. The EtOAc sample was submitted to preliminary phytochemical screening and showed the presence of phenols, flavanoids of the flavones type, flavonols and xanthones, triterpenoids, and alkaloids. Then, flavonoid compounds (369.58±0.074mgEQ/g) and total phenols (81.48±0.005mgEAG/g) were determined. EtOAc was evaluated for its toxicity, with Artemia salina, which showed low toxicity in all the studied doses. In the pharmacological action tests, the doses of 3, 10, or 30 mg/mL were used; 20 µL; oral (v.o.) or intraperitoneal (i.p.). The locomotor activity was evaluated in the open field test, which showed a decrease in the fish. And the anxiolytic activity, in the light & dark preference test, showed that EtOAc at 30 mg/mL, when administered intraperitoneally (IP), has an anxiolytic effect similar to Diazepam IP control. Thus the EtOAC of M. albicans showed the presence of total phenols and several flavonoids, with low toxicity, in which the highest dose presented anxiolytic effect in Zebrafish.
Análise da qualidade físico-química do leite crú entregue a uma cooperativa beneficiadora do município de Juína-MT
Authors: Silvestrin Patricia Dalmás , Sodré Lainy Waleska de Brito , Oliveira Aline Pedrosa de 
Published: January 2022

A qualidade do leite crú para a indústria processadora está diretamente ligada às características do seu produto final. Assim, o leite cru como matéria-prima tanto para o processamento de leite fluido quanto para a produção de derivados deve apresentar-se com boas características físico-químicas, microbiológicas e sensoriais, por esta razão é indispensável que as indústrias realizem avaliações para o controle da qualidade e averiguação de fraudes. Este trabalho objetivou avaliar por meio de análises físico-químicas e de presença de fraudes, a qualidade do leite cru entregue a uma cooperativa beneficiadora no município de Juína-MT, a fim de verificar a conformidade com os parâmetros determinados pela legislação vigente. Os resultados indicaram que os teores médios de proteínas, lactose, sólidos totais, sólidos não gordurosos, densidade e acidez titulável encontraram-se dentro dos valores estabelecidos pelo preconizado pela IN 62 do MAPA para leite. Porém, os teores de gordura e crioscopia variaram, sendo apresentadas em sua maioria médias abaixo do valor mínimo estabelecido. Na determinação da temperatura, todas as médias estavam fora do padrão estabelecido, isso ocorreu pelo fato de que os produtores entregavam o leite em latões, sem nenhum tipo de refrigeração. O teste do alizarol se apresentou positivo em nove amostras e a pesquisa de fralde também foi positiva para adição de peróxido de hidrogênio em duas amostras e nenhuma amostra se apresentou positiva para adição de amido, resultados pouco expressivos em relação à 188 amostras analisadas. De modo geral, conclui-se que o leite cru recebido pela cooperativa localizada no município de Juína-MT apresentou boa qualidade físico-química.
Abordagem geral frente ao processo de transexualização: uma revisão narrativa da literatura
Authors: Araújo Ana Paula Ferreira , Costa Aline Paiva , Figueiredo Bárbara Queiroz de , Rosa Francisca Rafaela Pereira de Anorin Castro , Gonçalves Isadora de Olivera , Alves Júlia de Oliveira , Gomes Maria Jacilene de Araújo , Silva Murilo Henrique da 
Published: January 2022

Introdução: O processo de transexualização é definido como: transformar-se para ser aceita/o socialmente e evitar o sofrimento gerado por um corpo que não se habita. De acordo com o filósofo alemão Hans Jonas, a vida é uma unidade formada por corpo e alma, permitindo a liberdade de escolha. Com isso, não há como promover o conceito de saúde sem um pleno estado de bem-estar físico, mental e social. Objetivo: analisar o processo de transexualização envolvendo os aspectos biopsicossociais. Metodologia: Trata-se de uma revisão narrativa da literatura, com artigos selecionados nas bases de dados: National Library of Medicine (PubMed MEDLINE), EbscoHost, Google Scholar, Scientific Eletronic Library Online (SCIELO) e Biblioteca Virtual de Saúde (BVS) Resultados: De acordo com a revisão realizada, constatou-se que os aspectos mais relevantes para a discussão do processo de transexualização são as práticas cirúrgicas de redesignação sexual, além das alterações corporais advindas através da hormonioterapia e importância de entender o indivíduo em seu aspecto biopsicossocial, verificando as dificuldades enfrentadas durante esse período transicional. Ademais, é importante salientar que a hormonioterapia pode acarretar alguns riscos, sendo o mais prevalente o aumento dos índices de tromboembolismo venoso. Conclusão: De acordo com a revisão realizada, o processo de transexualização é algo que deve ser desmitificado pela sociedade hodierna, com isso, intervenções são necessárias para que exista vivência plena do processo transexualizador. Além disso, é de suma importância medidas socioeducativas que tratem a sexualidade das pessoas trans, auxiliando na prevenção das IST’s.
Transcatheter Mitral Valve-in-Valve Implantation With a New Transcatheter Heart Valve for Bioprosthetic Degeneration
Authors: Lu Yuntao , Yang Ye , Wang Wenshuo , Chen Jinmiao , Yin Minyan , Huang Liqi , Dong Lili , Wang Chunsheng , Wei Lai 
Published: January 2022

BackgroundTranscatheter mitral valve-in-valve (TMVIV) procedure with aortic transcatheter heart valves has recently become a less invasive alternative for patients with mitral bioprosthetic dysfunction. This study reports the initial experience of TMVIV implantation using the J-Valve System (JieCheng Medical Technology Corporation Ltd., Suzhou, China).MethodsA retrospective observational multicenter study was conducted to evaluate the short-term outcomes of TMVIV. In total, 26 consecutive patients with symptomatic bioprosthetic failure at eight hospitals underwent TMVIV using the J-Valve System between May 2019 and June 2021. Procedural results and clinical outcomes were analyzed using the Mitral Valve Academic Research Consortium criteria.ResultsThe mean age was 75.3 ± 7.1 years and 69.2% of patients were female. The mean Society of Thoracic Surgeons Predicted Risk of Mortality score was 12.3 ± 8.3%. The technical success rate was 96.2%. Nine of the 26 patients (34.6%) were implanted with a J-Valve of a size equal to the internal diameters of the deteriorated prostheses. At the 30-day and 1-year follow-ups, all-cause mortality was 3.8 and 16.0% and the stroke rates were 0 and 12.0%, respectively. Device-related mortality was 0% and the mean mitral valve gradient was 6.4 ± 2.7 mm Hg. No patient experienced device embolization, left ventricular outflow tract obstruction, or mitral valve reintervention. Postprocedural mitral regurgitation was none or trace in all the patients. All the patients were in the New York Heart Association (NYHA) class ≤ II at the last follow-up.Conclusion:Transcatheter implantation of the J-Valve System in high-risk patients with mitral bioprosthetic dysfunction was found to be a reasonable alternative and associated with good short-term outcomes.
ALKBH5 Regulates SPHK1-Dependent Endothelial Cell Angiogenesis Following Ischemic Stress
Authors: Kumari Rajesh , Dutta Roshan , Ranjan Prabhat , Suleiman Zainab Gbongbo , Goswami Sumanta Kumar , Li Jing , Pal Harish Chandra , Verma Suresh Kumar 
Published: January 2022

BackgroundEndothelial cells dysfunction has been reported in many heart diseases including acute myocardial infarction, and atherosclerosis. The molecular mechanism for endothelial dysfunction in the heart is still not clearly understood. We aimed to study the role of m6A RNA demethylase alkB homolog 5 (ALKBH5) in ECs angiogenesis during ischemic injury.Methods and ResultsECs were treated with ischemic insults (lipopolysaccharide and 1% hypoxia) to determine the role of ALKBH5 in ECs angiogenesis. siRNA mediated ALKBH5 gene silencing was used for examining the loss of function. In this study, we report that ALKBH5 levels are upregulated following ischemia and are associated with maintaining ischemia-induced ECs angiogenesis. To decipher the mechanism of action, we found that ALKBH5 is required to maintain eNOS phosphorylation and SPHK1 protein levels. ALKBH5 silencing alone or with ischemic stress significantly increased SPHK1 m6A mRNA methylation. In contrast, METTL3 (RNA methyltransferase) overexpression resulted in the reduced expression of SPHK1.ConclusionWe reported that ALKBH5 helps in the maintenance of angiogenesis in endothelial cells following acute ischemic stress via reduced SPHK1 m6A methylation and downstream eNOS-AKT signaling.
Effects of Split Application of Urea on Greenhouse Gas and Ammonia Emissions From a Rainfed Maize Field in Northeast China
Authors: Dong Dan , Yang Weichao , Sun Hao , Kong Shuang , Xu Hui 
Published: January 2022

Split application of nitrogen (N) fertilizers during different crop growth stages to fulfill the crop N requirements reduces soil mineral N concentrations and improves the efficiency of crop N fertilizer use, and can decrease nitrous oxide (N2O) emission from the soil. However, inconsistent results regarding N2O emissions have been reported in rainfed areas. Furthermore, few long-term studies have explained the effects of split N application on soil methane (CH4) flux, thus limiting complete assessment of the effects of split N application on total greenhouse gas (GHG) emissions. Therefore, long-term monitoring is urgently required to understand the impacts of split N application on GHG emissions in rainfed areas. In this study, a 6-year field experiment was conducted in a rainfed maize (Zea mays L.) field in Northeast China. The experiment included three treatments: no N application representing control (CK), single application at the sowing stage of maize (SU), and split N at the sowing and jointing stages at a ratio of 1: 2 (SF). Between the sowing and jointing stages, N2O emissions were significantly higher in SU than in SF. However, high N2O emissions were observed in SF for 1 month after N application at the jointing stage possibly because the time of N application coincided with optimum precipitation and soil temperature conditions, which stimulated N2O emissions. Overall, the total N2O emissions showed no significant difference between SU and SF. During the study period, split application of N fertilizer did not significantly affect the cumulative CH4 flux. Compared to CK, the yield-scaled GWP in SF treatment increased by 18.7% (p &lt; 0.05). Ammonia (NH3) volatilization in SF was 272% higher than that in SU. The findings indicated that split N application exhibited an environmental risk by increasing the yield-scaled GWP and NH3 emissions in the field. Thus, this study suggested that single N application applied in the sowing stage should be employed in rainfed fields to mitigate the yield-scaled GWP and NH3 emissions, and maintain efficient maize yields.
Expression Signature of the AT-Rich Interactive Domain Gene Family Identified in Digestive Cancer
Authors: Lu Yongqu , Liu Zhenzhen , Wang Wendong , Chen Xin , Zhou Xin , Fu Wei 
Published: January 2022

BackgroundThe AT-rich interactive domain (ARID) gene family of 15 proteins has an important role in development and proliferation. Gene expression alterations of the ARID family are correlated with the pathogenesis of digestive cancer, but systematic research has not been conducted.MethodsWe obtained transcriptome sequencing data, clinical characteristics and stemness indices of the seven main types of digestive cancer (cholangiocarcinoma, colon adenocarcinoma, oesophageal carcinoma, liver hepatocellular carcinoma, pancreatic adenocarcinoma, rectum adenocarcinoma and stomach adenocarcinoma) from public pan-cancer data to combine the analysis of the expression and prognostic signature of the ARID gene family. The stromal and immune scores for each sample were calculated to explore the correlations between the ARID gene family members and the tumour microenvironment.ResultsAfter screening, 1,920 digestive cancer samples were included in our study. ARID3C was expressed at low levels throughout the digestive cancer samples. The expression levels of ARID1A and JARID1C were relatively high, but there was striking heterogeneity across the different cancer types for specific family members. The survival analysis indicated that many genes were significantly related to the prognosis of patients with liver hepatocellular carcinoma. The stemness indices, stromal score, and immune score analysis showed that the expression of a single ARID gene had characteristic consistency in each tumour, but the levels among the different genes still varied.ConclusionOur systematic study of the ARID gene family and its association with the immune infiltrate, tumour microenvironment and outcomes of digestive cancer patients focus on the complex relations and indicate the need to study each ARID member as an individual in a specific cancer type.
Effect of the Early Administration of Selective Serotonin Reuptake Inhibitors on the Time Course of Poststroke Fatigue: A 2-Year Longitudinal Study
Authors: Wang Jinjing , Wang Fang , Gu Mengmeng , Xiao Lulu , Xu Pengfei , Guo Jianglong , Jiang Shiyi , Liu Yujing , Liu Yuanlu , Sun Wen , Liu Xinfeng 
Published: January 2022

BackgroundPoststroke fatigue (PSF) is a dynamic process over time. Current evidence for interventions for PSF is limited. Our study investigated the effects of selective serotonin reuptake inhibitors (SSRIs) on the time course of PSF.MethodsThe patients with acute ischaemic stroke were enrolled in this study. All patients were scored with the Fatigue Severity Scale (FSS) at baseline and 6, 12, and 24 months after the index stroke. The time course of PSF was classified as non-PSF, incident PSF, recovered PSF and persistent PSF according to the PSF status at baseline and the 24-month follow-up. Multivariate logistic regression analysis and generalized mixed model were applied to explore the relationships between SSRIs and the time course of PSF.ResultsEight hundred forty-seven patients were analyzed in this study. No significant association between SSRIs and the time course of PSF was observed in all patients (p = 0.076). The subgroup analyses indicated that SSRI antidepressants reduced the risk of incident PSF [Odds Ratio (OR) 0.23; 95% confidence interval (CI) 0.05–0.96, p = 0.044] and persistent PSF (OR 0.28; 95% CI 0.09–0.90, p = 0.033) in the PSD subgroup, but not in the non-PSD group. In the longitudinal analysis, generalized logistical mixed-effect models indicated that early administration of SSRIs reduced the risk (OR 0.955; 95% CI 0.928–0.984, p = 0.002) and severity (β = −0.018, p = 0.041) of PSF in the PSD subgroup.ConclusionNo relationship was identified between the use of SSRIs and the time course of PSF in all patients. However, these drugs might be effective in PSF patients with depression.
Prevalence, Incidence, and External Causes of Traumatic Spinal Cord Injury in China: A Nationally Representative Cross-Sectional Survey
Authors: Jiang Bin , Sun Dongling , Sun Haixin , Ru Xiaojuan , Liu Hongmei , Ge Siqi , Fu Jie , Wang Wenzhi 
Published: January 2022

Background and PurposeThe epidemiological characteristics of traumatic spinal cord injury (TSCI) in China are unclear. Thus, we aimed to study prevalence, incidence, and external causes of TSCI in China nationwide.MethodsIn 2013, we conducted a nationally representative, door-to-door epidemiological survey on TSCI in China using a complex, multistage, probability sampling design.ResultsIn China, the point prevalence of TSCI standardized to the China census population 2010 was 569.7 (95% CI: 514.2–630.4) per 1,000,000 in the population, 753.6 (95% CI: 663.3–854.3) per 1,000,000 among men, and 387.7 (95% CI: 324.8–461.1) per 1,000,000 among women. The incidence of TSCI standardized to the China census population 2010 was 49.8 (95% CI: 34.4–70.7) per 1,000,000 per year in the population, 63.2 (95% CI: 38.9–98.5) per 1,000,000 among men, and 36.9 (95% CI: 19.5–65.9) per 1,000,000 among women. Among the 415 TSCI events in 394 prevalent cases, the top three injury causes were falls (55.2%), motor vehicle collisions (MVCs) (26.5%), and strike injuries (10.1%), while other injury causes including gunshot and explosion accounted for 8.2%. Among the 394 prevalent cases, the mean age of patients at the time of injury was 43.7 ± 17.1 years; the male-to-female ratio was 1.86:1.ConclusionIt is estimated that there are 759,302 prevalent patients with TSCI in total and 66,374 new TSCI cases annually in China. Falls and MVCs are still 2 major external causes for TSCI in China.
Evaluation of Lung Tumor Target Volume in a Large Sample: Target and Clinical Factors Influencing the Volume Derived From Four-Dimensional CT and Cone Beam CT
Authors: Li Fengxiang , Zhang Tingting , Sun Xin , Qu Yanlin , Cui Zhen , Zhang Tao , Li Jianbin 
Published: January 2022

Background and PurposeThis study aimed to systematically evaluate the influence of target-related and clinical factors on volume differences and the similarity of targets derived from four-dimensional computed tomography (4DCT) and cone beam computed tomography (CBCT) images in lung stereotactic body radiation therapy (SBRT).Materials and Methods4DCT and CBCT image data of 210 tumors from 195 patients were analyzed. The internal gross target volume (IGTV) derived from the maximum intensity projection (MIP) of 4DCT (IGTV-MIP) and the IGTV from CBCT (IGTV-CBCT) were compared with the reference IGTV from 10 phases of 4DCT (IGTV-10). The target size, tumor motion, and the similarity between IGTVs were measured. The influence of target-related and clinical factors on the adequacy of IGTVs derived from 4DCT MIP and CBCT images was evaluated.ResultsThe mean tumor motion amplitude in the 3D direction was 6.5 ± 5 mm. The mean size ratio of IGTV-CBCT and IGTV-MIP compared to IGTV-10 in all patients was 0.71 ± 0.21 and 0.8 ± 0.14, respectively. Female sex, greater BSA, and larger target size were protective factors, while the Karnofsky Performance Status, body mass index, and motion were risk factors for the similarity between IGTV-MIP and IGTV-10. Older age and larger target size were protective factors, while adhesion to the heart, coexistence with cardiopathy, and tumor motion were risk factors for the similarity between IGTV-CBCT and IGTV-10.ConclusionClinical factors should be considered when using MIP images for defining ITV, and when using CBCT images for verifying treatment targets.
MRI Based Radiomics Compared With the PI-RADS V2.1 in the Prediction of Clinically Significant Prostate Cancer: Biparametric vs Multiparametric MRI
Authors: Chen Tong , Zhang Zhiyuan , Tan Shuangxiu , Zhang Yueyue , Wei Chaogang , Wang Shan , Zhao Wenlu , Qian Xusheng , Zhou Zhiyong , Shen Junkang , Dai Yakang , Hu Jisu 
Published: January 2022

PurposeTo compare the performance of radiomics to that of the Prostate Imaging Reporting and Data System (PI-RADS) v2.1 scoring system in the detection of clinically significant prostate cancer (csPCa) based on biparametric magnetic resonance imaging (bpMRI) vs. multiparametric MRI (mpMRI).MethodsA total of 204 patients with pathological results were enrolled between January 2018 and December 2019, with 142 patients in the training cohort and 62 patients in the testing cohort. The radiomics model was compared with the PI-RADS v2.1 for the diagnosis of csPCa based on bpMRI and mpMRI by using receiver operating characteristic (ROC) curve analysis.ResultsThe radiomics model based on bpMRI and mpMRI signatures showed high predictive efficiency but with no significant differences (AUC = 0.975 vs 0.981, p=0.687 in the training cohort, and 0.953 vs 0.968, p=0.287 in the testing cohort, respectively). In addition, the radiomics model outperformed the PI-RADS v2.1 in the diagnosis of csPCa regardless of whether bpMRI (AUC = 0.975 vs. 0.871, p= 0.030 for the training cohort and AUC = 0.953 vs. 0.853, P = 0.024 for the testing cohort) or mpMRI (AUC = 0.981 vs. 0.880, p= 0.030 for the training cohort and AUC = 0.968 vs. 0.863, P = 0.016 for the testing cohort) was incorporated.ConclusionsOur study suggests the performance of bpMRI- and mpMRI-based radiomics models show no significant difference, which indicates that omitting DCE imaging in radiomics can simplify the process of analysis. Adding radiomics to PI-RADS v2.1 may improve the performance to predict csPCa.