bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcatheter valve repair of tricuspid regurgitation with the PASCAL system: TriCLASP study 30‐day results
Authors: Baldus Stephan , Schofer Niklas , Hausleiter Jörg , Friedrichs Kai , Lurz P. , Luedike Philipp , Frerker Christian , Nickenig G. , Lubos Edith , Pfister Roman , Körber M. I. , Kalbacher Daniel , Näbauer Michael , Besler C. , Mahabadi Amir Abbas , Weber Marcel , Zdanyte M. , Ren C. B. , Geisler Tobias 
Published: November 2022

AbstractBackgroundSevere tricuspid regurgitation (TR) is independently associated with increased morbidity and mortality. Percutaneous transcatheter approaches may offer an alternative for patients not amenable to surgery.MethodsTriCLASP is a prospective, single‐arm, multicenter European post‐market clinical follow‐up study (NCT04614402) to evaluate the safety and performance of the PASCAL system (Edwards Lifesciences) in patients with severe or greater TR. At 30 days, a composite of major adverse events (MAEs) adjudicated by a clinical events committee, echocardiographic parameters adjudicated by core laboratory, and clinical, functional, and quality‐of‐life measures were evaluated.ResultsMean age of the 74 enrolled patients was 80.3 years, with 58.1% female, 90.5% systemic hypertension, and 77.0% in New York Heart Association (NYHA) class III/IV. Mean Society for Thoracic Surgeons score (MV repair) was 9.0%. TR severity was significantly reduced at discharge (p < 0.001) and sustained at 30 days (p < 0.001), and 90.0% of patients achieved ≤moderate TR. The composite MAE rate at 30 days was 3.0%, including 4 events in 2 patients: cardiovascular mortality 1.5%, stroke 1.5%, renal complications requiring unplanned dialysis or renal replacement therapy 1.5%, and severe bleeding 1.5%. There were no nonelective tricuspid valve reinterventions, major access site and vascular complications, major cardiac structural complications, or device embolizations. NYHA class I/II was achieved in 55.8%, 6‐minute walk distance improved by 38.2 m (p < 0.001), and Kansas City cardiomyopathy questionnaire scores improved by 13.4 points (p < 0.001).ConclusionExperience with the PASCAL transcatheter valve repair system in a European post‐market setting confirms favorable safety and effectiveness at 30 days. TR significantly reduced, and clinical, functional, and quality‐of‐life outcomes significantly improved. This study is ongoing. Clinical Trial Registration: The study is ongoing and registered on ClinicalTrials.gov as NCT04614402. The current analysis is an interim report.
Trans‐caval aspiration artherectomy/thrombectomy of large mobile plaques and thrombi in aortic arch and descending aorta
Authors: Chiang Michael , Villablanca Pedro A. , O'Neill William W. , Frisoli Tiberio 
Published: November 2022

AbstractAspiration thrombectomy with the AngioVac is approved for percutaneous removal of thrombus in the venous system. While not approved for aspiration of thrombus or other mass in the left heart or arterial system, it has been used in that setting. Patients with left heart or arterial mass are often deemed unfavorable for surgery and treated conservatively. This may not be the best option for all patients, as some may have lesions that represent a short‐term increased risk of complications, for which intervention and aspiration could be considered reasonable. Unfortunately, femoral arteries sizes often cannot accommodate the Angiovac current aspiration cannula dimensions. Here, we demonstrated trans‐caval approach for aspiration thrombectomy of extensive aortic mobile plaque and thrombus.
Rare case of intracerebral hemorrhage in anaphylactic shock following administration of intramuscular adrenaline: A case report
Authors: Yamamoto Shunki , Hongo Takashi , Tamura Tomokazu , Yumoto Tetsuya , Naito Hiromichi , Nakao Atsunori 
Published: November 2022

AbstractIntracerebral hemorrhage should be considered as a possible adverse event in patients with anaphylactic shock who are treated with adrenaline administration, especially in those at high risk of serious bleeding events.
A complex case of necrobiotic xanthogranuloma with IgG‐kappa paraproteinemia: Disease regression achieved with melphalan and prednisone combination therapy
Authors: Malherbe Jacques A. J. , Cooney Julian 
Published: November 2022

AbstractNecrobiotic xanthogranuloma (NXG) is a rare dermatosis that is often associated with monoclonal paraproteinemia and hematological malignancies. We report the rare case of an 84‐year‐old gentleman with extensive truncal NXG and IgG‐kappa paraproteinemia who achieved significant disease regression following six cycles of combination melphalan/prednisone therapy.
CMR detects extensive intracavitary thrombi as solitary clinical presentation of Antiphospholipid Syndrome: A case report
Authors: Reiter Theresa , Demirbas Senem , Schmalzing Marc , Voelker Wolfram , Bauer Wolfgang R. , Güder Gülmisal 
Published: November 2022

AbstractIntracavitary thrombi are an important differential diagnosis of cardiac masses. Cardiac magnetic resonance imaging (CMR) allows their non‐invasive characterization. This case highlights extensive cardiac thrombi detected by CMR as solitary presentation of antiphospholipid syndrome.
Metal‐Organic Frameworks for Catalytic Construction of C−B Bond and Related Reactions
Authors: Prakash Aishwarya , Saini Suresh , Basappa Suma , Gupta Dharmendra Kumar , Mao Lujia , Bose Shubhankar Kumar 
Published: November 2022

AbstractOrganoboranes are important reagents in modern synthetic organic chemistry. The C−B bonds presented in these derivatives are transformable into a C−X (X=C, N, O, and halogen) bonds stereoretentively to provide valuable complex molecules employed in medicinal chemistry, agrochemicals, natural products, and materials science. The homogeneous transition‐metal‐catalyzed borylation reaction is one of the most effective methodologies to synthesize organoboranes. However, these catalytic systems suffer from the inability to recover the catalysts and metal contamination into products, which limits their application towards chemical and pharmaceutical processes. Recently, the metal‐organic frameworks (MOFs)‐based heterogeneous catalytic systems have gained prominence to overcome these limitations. This review article surveys the employment of MOFs‐based catalysts in the borylation reactions, and the related mechanisms are also discussed.
Conformationally Restricted β‐Sheet Breaker Peptides Incorporating Cyclic α‐Methylisoserine Sulfamidates
Authors: Mazo Nuria , Navo Claudio D. , Peccati Francesca , Andreo Jacopo , Airoldi Cristina , Goldsztejn Gildas , Çarçabal Pierre , Usabiaga Imanol , Sodupe Mariona , Wuttke Stefan , Busto Jesús H. , Peregrina Jesús M. , Cocinero Emilio J. , Jiménez‐Osés Gonzalo 
Published: November 2022

AbstractPeptides containing variations of the β‐amyloid hydrophobic core and five‐membered sulfamidates derived from β‐amino acid α‐methylisoserine have been synthesized and fully characterized in the gas phase, solid state and in aqueous solution by a combination of experimental and computational techniques. The cyclic sulfamidate group effectively locks the secondary structure at the N‐terminus of such hybrid peptides imposing a conformational restriction and stabilizing non‐extended structures. This conformational bias, which is maintained in the gas phase, solid state and aqueous solution, is shown to be resistant to structure templating through assays of in vitro β‐amyloid aggregation, acting as β‐sheet breaker peptides with moderate activity.
An updated review on systemic and targeted therapies for vitiligo
Authors: Maghfour Jalal , Hamzavi Iltefat H. , Mohammad Tasneem F. 
Published: November 2022

AbstractBackgroundVitiligo is a multifactorial disease characterized by depigmented macules and patches and is associated with a substantial disease burden. Systemic treatment of vitiligo is utilized for unstable or widespread disease.Materials and MethodsIn this review, we will examine the evidence regarding the systemic agents that are currently used in the management of vitiligo, discuss emerging targeted therapies, and evaluate potential future treatment perspectives.ResultsAlthough an array of systemic agents have been shown to halt disease progression in patients with vitiligo, their use is limited due to concerns regarding side effects and unclear efficacy. Targeted therapies such as topical ruxolitinib, a janus kinase inhibitor, has become the first and only FDA approved agent for repigmentation in patients with vitiligo.DiscussionIn recent years, significant progress has been made in understanding the molecular and genetic factors influencing disease pathogenesis, enabling the development of targeted therapies, such as janus kinase inhibitors. Additional ongoing clinical trials are likely to improve the disease outcomes and quality of life of patients with vitiligo.
Effects of empagliflozin on erythropoiesis in heart failure: data from the Empire HF trial
Authors: Fuchs Andersen Camilla , Omar Massar , Glenthøj Andreas , El Fassi Daniel , Møller Holger J. , Lindholm Kurtzhals Jørgen A. , Styrishave Bjarne , Kistorp Caroline , Tuxen Christian , Poulsen Mikael K. , Faber Jens , Køber Lars , Gustafsson Finn , Møller Jacob E. , Schou Morten , Jensen Jesper 
Published: November 2022

AimsIt remains unknown whether the consistently observed increase in haematocrit with sodium–glucose cotransporter 2 inhibitors is caused by diuresis‐associated haemoconcentration or increased erythropoiesis. We aimed to investigate the early effect of empagliflozin on erythropoiesis and iron metabolism in patients with heart failure with reduced ejection fraction (HFrEF).Methods and resultsThe Empire HF was a double‐blind, randomized, placebo‐controlled trial. Patients with a left ventricular ejection fraction (LVEF) ≤40%, New York Heart Association (NYHA) class I–III symptoms, and on stable guideline‐directed HFrEF therapy were randomly assigned (1:1) to empagliflozin or matching placebo once daily for 12 weeks. Exploratory outcomes reflecting changes in erythropoiesis and iron metabolism were analysed. In total, 190 patients were randomized. Baseline characteristics were well‐balanced between the groups (age: mean 64 [± 11] years; male: 85%; LVEF: mean 29 [± 8)%; NYHA class II: 78%; type 2 diabetes: 13%; anaemia: 28%; chronic kidney disease: 13%). In this post hoc analysis, erythropoietin was increased with empagliflozin compared to placebo from baseline to 12 weeks (adjusted mean difference 2.6 IU/L, 95% confidence interval [CI] 0.8–4.4; p = 0.0046). Moreover, hepcidin was reduced (adjusted ratio of change 0.76, 95% CI 0.59–0.97; p = 0.031), with no change observed for erythroferrone (adjusted ratio of change 1.17, 95% CI 0.86–1.60; p = 0.31) compared to placebo. No significant treatment‐by‐subgroup interactions were observed regarding baseline type 2 diabetes, anaemia, or chronic kidney disease (pinteraction >0.05).ConclusionThese findings suggest that empagliflozin increases erythropoiesis and augments early iron utilization in patients with HFrEF. These mechanisms may contribute to the cardioprotective properties of empagliflozin.
Bifuntional Materials Containing Preyssler‐type Polyoxometalates and Iron Phenanthroline Stabilized with Poly (Allylamine Hydrochloride) for Electrochromic Energy Storage Devices
Authors: Liu Shuping , Zhang Jie , Song Yingying , Feng Suyang , Yang Yanyan , Qu Xiaoshu 
Published: November 2022

AbstractElectrochromic supercapacitors have received extensive attention owing to their ability to combine electrochromism and energy storage properties. In this paper, a bifunctional electrode material based on Preyssler‐type tungstophosphate (P5W30), polyelectrolyte poly(allylamine hydrochloride) chain (PAH) modified by the iron complex (Fe(phen)3) was synthesized by Layer‐by‐Layer method (LbL). Compared with the film without PAH, the composite film displays large optical contrast (35.17 %), fast response time (2.49/0.90 s for coloring/bleaching), great coloration efficiency (94.73 cm2 ⋅ C−1) and high specific capacitance (10.45 mF cm−2). Moreover, the good cycling stability (83.66 % retention of the original optical modulation after 1500 cycles, capacity retention rate is 91.46 % after 500 cycles) is achieved. In addition, the composite film is also able to visually detect the energy storage level through reversible and rapid color changes, and further use it to assemble device. This work provides an promising candidate for electrochromic and energy storage devices.
Topological controls on catchment‐scale sediment dynamics
Authors: Walley Yasmin , Henshaw Alexander J. 
Published: November 2022

AbstractThe episodic transfer of sediment from source to sink is a fundamental process in fluvial systems that influences river morphology, aquatic and riparian ecosystems, and risk from a variety of associated natural hazards. The hierarchical structure of river networks has been identified as a key control on spatiotemporal patterns of sediment routing at the catchment scale, but very few studies have systematically explored this relationship. In this paper, we investigate the role that drainage network topology plays in modulating sediment flux and morphodynamic activity. We simulate the geomorphological responses of four topologically distinct catchments from New Zealand's South Island to sequences of flood events using a landscape evolution model. Spatiotemporal variation in different types of geomorphological activity is assessed via a link‐based framework, and potential interrelationships between within‐network changes and discharge and sediment yield at the catchment outlets are explored to provide insights into relative levels of network connectivity. We also investigate the occurrence of geomorphic ‘hotspots’ in relation to network topology, and their impact on the downstream transfer of sediment in different network ‘types’. Dissected networks were found to exhibit much greater spatiotemporal variability in geomorphological activity compared to narrow, elongated networks where change was concentrated in mainstem reaches. The frequency and significance of geomorphological hotspots are shown to vary between network types, with strong contrasts evident between dissected networks with steep topography and elongated networks with more gentle gradients. Dissected networks exhibited mostly non‐linear relationships between within‐network geomorphological activity and outlet discharge and sediment yield. However, moderate to strong linear relationships between these variables were observed in mainstem‐dominated networks, indicating much greater levels of connectivity across a range of flow conditions. We discuss the implications of these findings on the transformation of environmental signals through fluvial systems with different topological structures, and the differential responses of catchments to disturbance events.
Optimization of parallel implementation ofUNRESpackage for coarse‐grained simulations to treat large proteins
Authors: Sieradzan Adam K. , Sans‐Duñó Jordi , Lubecka Emilia A. , Czaplewski Cezary , Lipska Agnieszka G. , Leszczyński Henryk , Ocetkiewicz Krzysztof M. , Proficz Jerzy , Czarnul Paweł , Krawczyk Henryk , Liwo Adam 
Published: November 2022

AbstractWe report major algorithmic improvements of the UNRES package for physics‐based coarse‐grained simulations of proteins. These include (i) introduction of interaction lists to optimize computations, (ii) transforming the inertia matrix to a pentadiagonal form to reduce computing and memory requirements, (iii) removing explicit angles and dihedral angles from energy expressions and recoding the most time‐consuming energy/force terms to minimize the number of operations and to improve numerical stability, (iv) using OpenMP to parallelize those sections of the code for which distributed‐memory parallelization involves unfavorable computing/communication time ratio, and (v) careful memory management to minimize simultaneous access of distant memory sections. The new code enables us to run molecular dynamics simulations of protein systems with size exceeding 100,000 amino‐acid residues, reaching over 1 ns/day (1 μs/day in all‐atom timescale) with 24 cores for proteins of this size. Parallel performance of the code and comparison of its performance with that of AMBER, GROMACS and MARTINI 3 is presented.
Computationally rational design of metal‐involving halogen bonds with π‐covalency: Structures and bonding analysis
Authors: Zhang Congcong , Bai Han , Hu Junyuan , Guo Kai , Zhao Lili 
Published: November 2022

AbstractTraditional π‐covalent interactions have been proved in the non‐metal halogen bond adducts formed by chloride and halogenated triphenylamine‐based radical cations. In this study, we have rationally designed two metal‐involving halogen bond adducts with π‐covalency property, such as [L1‐Pd···I‐PTZ]+(i.e., 1) and [L2‐Pd···I‐PTZ]+(i.e., 2), in which the square‐planar palladium complexes serve as halogen bond acceptor and 3,7‐diiodo‐10H‐phenothiazine radical cation (i.e., [I‐PTZ]•+) acts as halogen bond donor. Noncovalent interaction analysis and quantum theory of atoms in molecules analysis revealed that there are notable halogen bond interactions along the Pd···I direction without genuine chemical bond formed in both designed adducts. Energy decomposition analysis together with natural orbital for chemical valence calculations were performed to gain insight into their bonding nature, which demonstrated the presence of remarkable π‐covalent interactions and σ‐covalent interactions in both 1 and 2. We therefore proposed a new strategy for building the metal‐involving halogen bonds with π‐covalency property, which will help the further development of new types of halogen bonds.
Understanding undersociality: Intentions, impressions, and interactions
Authors: Kumar Amit , Epley Nicholas 
Published: November 2022

AbstractRatner et al. (2023) and Silver and Small (2023) raise deeply interesting questions about the broad consequences of increasing sociality, about people's ability to anticipate the outcomes of sociality, and about broader issues people may be considering when thinking of connecting with another person. We focus this response on the potential role of intentions and anticipated impressions in affecting undersociality, as well as the possibility of interactions that could moderate the gap between people's expectations of social engagement and their actual experiences. Many unanswered and important questions remain in need of critical empirical attention. We encourage future research that provides a better understanding of undersociality by focusing on intentions, impressions, and interactions.
Undersociality is unwise
Authors: Kumar Amit , Epley Nicholas 
Published: November 2022

AbstractWise decisions are often guided by an accurate understanding of the expected values of different possible choices. In social contexts, wisdom comes from understanding how others are likely to respond to one's actions, enabling people to make choices that maximize both their own and others' outcomes. Our research suggests that miscalibrated social cognition may create a systematic barrier to wiser decisions in social life. From expressing appreciation to offering support to performing acts of kindness, this program of research indicates that decisions to engage with others are driven by how people expect a recipient to respond, but that people consistently underestimate how positively others will respond to their other‐oriented actions. Because connecting with others consistently increases people's own wellbeing, miscalibrated social cognition may lead toundersociality: being overly reluctant to reach out and connect with others. Miscalibrated expectations about social engagement can create markets for products that help people overcome these barriers in order to consume their time, money, and effort more wisely.
Histomorphological, immunohistochemical, and ultrastructural study on ontogeny of ileocaecal lymphoglandular complexes in prenatal and postnatal Indian buffalo: An innate mucosal immune barrier
Authors: Kapoor Kritima , Singh Opinder 
Published: November 2022

AbstractThe present study was conducted on prenatal and postnatal development of lymphoglandular complexes (LGCs) in ileocaecal region of buffalo fetuses (n = 15) ranging from 11.5 cm curved crown rump length (CVRL) (80 days) to 100 cm CVRL (299 days) and neonatal buffalo calves (n = 10). The fetuses were categorized into three groups based on their CVRL. LGC formation was not evident in ileocaecal junction up to 32 cm CVRL (145 days). At 35 cm CVRL (152 days), diffuse lymphocytes were scattered around the base of glands that encircled them. At 54 cm CVRL (195 days), lymphoid aggregates were present in submucosa around deep submucosal glands and formed primordia of LGCs in ileocaeccal orifice region. At 100 cm CVRL (299 days), these complexes were completely visible grossly. The distinguished lymphoid nodules in submucosa were invaded by submucosal extensions of overlying mucosal glands to form a large clear complex of glands and lymphoid nodules called as “Lymphoglandular complex” at this stage. It is the first report of prenatal development of LGCs in large intestine of buffaloes. Abundant CD3+ T cells were observed towards periphery of LGC. In neonates, these complexes were uniform, few with demarcation into dark and light zones that is, germinal center formation. Lymphocytes interspersed in lamina propria were mainly CD3+ T lymphocytes. In conclusion, the development of LGCs in ileocaecal region started prenatally in terms of all its cellular components into completely developed and immunocompetent to generate mucosal immunity.
Chemical exchange in the vine shoots–wine system when used as an innovative enological procedure
Authors: Cebrián‐Tarancón Cristina , Fernández‐Roldán Francisco , Sánchez‐Gómez Rosario , Alonso Gonzalo Luis , Salinas María Rosario 
Published: November 2022

AbstractBACKGROUNDPruned vine shoots prepared as toasted fragments (SEGs) have recently been proposed as enological additives capable of producing differentiated quality wines. In this work, the composition of phenolic and volatile compounds of SEGs, before and after contact with wines, has been studied.RESULTSSEGs from Tempranillo and Cabernet Sauvignon were used, which were kept in contact for 30 days with red wines made with the same varieties. Phenolic compounds were the ones with the highest sorption in SEGs, but a variety‐dependent behavior was observed in anthocyanins and flavonols, with an increase in some malvidin derivatives only in Tempranillo wine and an increase in (−)‐epicatechin in SEGs and Cabernet Sauvignon wine. trans‐Resveratrol was transferred from SEGs to wine but also increased in SEGs regardless of the variety used. The volatile compounds that were most retained in SEGs were phenylethyl alcohol and ethyl lactate, but in lower proportions than the phenolic compounds and without important changes in wines.CONCLUSIONThe high content of phenolic compounds in SEGs after their use as enological additives suggests that they could be considered as a source of anthocyanins and as raw materials for phenolic compounds with recognized antioxidant properties. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.