bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treating ‘osteoporosis’: a near miss in an unusual case of FGF-23-mediated hypophosphataemic osteomalacia
Authors: Lin Mike , Ganda Kirtan 
Published: December 2022

Summary
We present the case of a 60-year-old female who developed repeated atraumatic stress fractures. She was initially diagnosed with osteoporosis based on her dual-energy X-ray absorptiometry (DXA) scan bone mineral density (BMD) T-scores and started on denosumab therapy. Secondary osteoporosis screen revealed abnormal myeloma screen and low serum phosphate levels. It was thought that the patient had multiple myeloma with associated Fanconi-related tubular dysfunction. However, fibroblast growth factor-23 (FGF-23) levels were grossly elevated, making Fanconi syndrome unlikely. The patient was subsequently diagnosed with two separate conditions, namely cardiac amyloid light-chain (AL) amyloidosis and FGF-23-related hypophosphataemia, likely due to tumour-induced osteomalacia. This case highlights the importance of excluding osteomalacia as a cause of low BMD and checking FGF-23 levels in the workup for hypophosphataemia.

Learning Points

Tumour-induced osteomalacia is a difficult diagnosis as the tumour is often small and slow growing. Imaging may fail to identify a tumour, and treatment therefore consists of calcitriol and phosphate replacement.

Tumour-induced osteomalacia should be suspected in the adult presenting with new-onset hypophosphataemia, elevated FGF-23 levels and isolated renal phosphate wasting.

Serum phosphate is not part of the routine chemistry panels. Routinely checking phosphate levels prior to initiating antiresorptive therapy is warranted.

DXA cannot distinguish low bone mineral density due to osteoporosis from osteomalacia. Antiresorptive therapy should be avoided in osteomalacia due to the risk of clinical and radiographic deterioration.
Thermodynamic properties of melts of Cu—Yb and Cu—In—Yb systems
Authors:   I. M. Frantsevich Institute for Problems of Materials Science of NAS of Ukraine, Romanova L.O. , Kudin V. G. ,   Taras Shevchenko National University of Kyiv, Dudnik A. S. ,   I. M. Frantsevich Institute for Problems of Materials Science of NAS of Ukraine, Ivanov M. I. ,   I. M. Frantsevich Institute for Problems of Materials Science of NAS of Ukraine, Sudavtsova V. S. ,   I. M. Frantsevich Institute for Problems of Materials Science of NAS of Ukraine
Published: December 2022

The partial and integral enthalpies of mixing of the melts the Cu-Yb system in the composition range 0 < xCu <0,7 and for 5 sections of Cu – In – Yb system with a constant ratio of the other two components (xCu/xIn=0,36/0,64; xCu/xIn= 0,62/0,38; xIn/xYb= 0,62/0,38; xCu/xYb =0,64/0,36; xCu/xYb =0,21/0,79) to x3 = 0.3 by method isoperibolical calorimetry in the temperature range 1453-1473K first were determined. Using the model of ideal associated solutions (IAR), all the thermodynamic properties (Gibbs energies of mixing melts, enthalpy and entropy of formation of intermetallic compounds and associates) of the Cu–Yb system were calculated. It turned out that the activity of the components in the melts of this system exhibit small negative deviations from ideal solutions. Calculations using the IAR model also made it possible to establish that with increasing temperature it increases slightly, but more significantly. Also were obtained the coordinates of the liquidus curve of the diagram state of the studied system.	The principal contribution to the enthalpies of mixing in the liquid alloysof the Cu–In–Yb system gives the border subsystem In–Yb. Because the minimum of the mixing enthalpies in the ternary sysytem Cu–In–Yb shifts towards the equiatomic alloy concentration of subsystem In–Yb (-36,5±1,0) at Т= 1453 К. Using the experimental partial and integral enthalpies of mixing, the activities of the components in the melts of binary limiteyted system of melts of the Cu–In–Yb ternary system, calculated according to «geometric» and the Redlich-Kister-Mujian models in a wide range of concentrations. It is established that the experimental ∆H, and calculated analogical datas according to the Redlich-Kister-Mujianu model agree between. It is shown that the activities of the components in the melts of this system, calculated according to the Redlich-Kister model, show small negative deviations from ideal solutions at 1453 K. From these of data calculated G, S. It was found that Gmin = –19 kJ/mol, Smin = –15 J/mol*K for the alloy In0,5Yb0,5. This correlates with the determined thermochemical properties of the melts Cu –In– Yb system. Keywords: calorimetry, the melts, intermetallic, thermodynamic properties, Cu, Yb, In, the model of ideal associated solutions, the Redlich—Kister—Mujianu model, phase equilibria.
Kilise Hukukunda Kadınların Manastır Hayatını Düzenleyen Son Papalık Genelgesi ‘Vultum Dei Quarere’ ile Gelen Yenilikler
Authors: KARATOSUN Musa Osman 
Published: December 2022

Öz:	Bu çalışmanın amacı münzevi yaşamı seçen kadınların manastır hayatına dair kaide ve kuralları birçok açıdan yeniden düzenlemek için Papa Francis tarafından 29 Haziran 2016 tarihinde yayınlanan Vultum Dei Quarere (Vechullah’ı Aramak) isimli bir belge ile gelen yeni düzenlemeleri incelemektir. Bu belgeyle birlikte kadınların manastır hayatını düzenleyen eski genelgelerin hükmü kaldırılmış, bazı yasalar güncellenmiş, yeni yasalar tesis edilmiş ve modern problemlere çözümler getirilmiştir. Bu belgede manastır hayatı ile ilgili hususlar on iki açıdan ele alınarak yeni reformların zemini oluşturulmuştur. Bunlar; eğitim, ibadet, Tanrı’nın sözleri, Evharistiya ve Günah çıkarma, cemaatle birlikte kardeşçe yaşam, özerklik, federasyonlar, kapalı mekân türleri, çalışma, sessizlik, iletişim kanalları ve asketik yaşam başlıkları altında genel hatları belirtilmiş ve ileri yıllarda çıkartılacak bir yönetmelik ile detaylı yasaların geleceği ilan edilmiştir. İki yıl sonra 1 Nisan 2018 tarihinde Cor Orans (Dua Eden Bir Kalp) isimli bir yönetmelik hazırlanmıştır. Bu yönetmelik genel hükümler ve çerçeve yasalar içermesinin yanı sıra özel kanunlarla manastır hayatının birçok alanını düzenleyen oldukça geniş kapsamlı bir belgedir.. Araştırmamızda manastır hayatına intizam getiren diğer papalık dokümanları da mukayeseli bir biçimde incelenmiş ve rahibelerin manastır hayatıyla ilgili Kilise Hukukunun nihai hükümleri önemli başlıklar altında analiz edilmiştir.
A Literature Review of the Factors Affecting the Compliance Costs of Environmental Regulation and Companies’ Productivity
Authors: Lah Lenart Milan , Kotnik Žiga 
Published: December 2022

Purpose: The aim of the paper is to identify potential factors that influence the relative size of environmental compliance costs through a literature review and propose a conceptual holistic model of the indirect impact of these factors on companies’ productivity levels. In the literature, the connection between costs associated with environmental regulation and companies’ productivity has been thoroughly tested within what is known as the Porter hypothesis, or simply PH.Design/methodology/approach: The paper applies the methods of integrative review of scientific literature and qualitative research with a document study.Findings: The results point to several key findings. First, the identified potential factors can be divided into two main categories, namely internal factors (size, sector, age, environmental awareness, etc.) and external factors (relevance of environmental regulation for businesses, environmental stimulus measures, quality of institutions, etc.). Second, the wide use of compliance costs within the indicators of stringency of environmental regulation suggests that the relative size of environmental compliance costs is likely to affect companies’ productivity.Practical Implications: The identification of factors affecting the size of compliance costs provides valuable insights to policy makers for the implementation of environmental regulation and making it more effective while not being discriminatory in terms of presenting an excessive burden to certain types of companies.Originality/significance: There has been a gap in the literature on environmental regulation compliance costs, as so far no study has comprehensively addressed all the potential factors influencing the relative size of environmental compliance costs for companies.
TFCGAN: Nonstationary Ground-Motion Simulation in the Time–Frequency Domain Using Conditional Generative Adversarial Network (CGAN) and Phase Retrieval Methods
Authors: Esfahani Reza D. D. , Cotton Fabrice , Ohrnberger Matthias , Scherbaum Frank 
Published: December 2022

ABSTRACTDespite the exponential growth of the amount of ground-motion data, ground-motion records are not always available for all distances, magnitudes, and site conditions cases. Given the importance of using time histories for earthquake engineering (e.g., nonlinear dynamic analysis), simulations of time histories are therefore required. In this study, we present a model for simulating nonstationary ground-motion recordings, which combines a conditional generative adversarial network to predict the amplitude part of the time–frequency representation (TFR) of ground-motion recordings and a phase retrieval method. This model simulates the amplitude and frequency contents of ground-motion data in the TFR as a function of earthquake moment magnitude, source to site distance, site average shear-wave velocity, and a random vector called a latent space. After generating the phaseless amplitude of the TFR, the phase of the TFR is estimated by minimizing all differences between the observed and reconstructed spectrograms. The simulated accelerograms produced by the proposed method show similar characteristics to conventional ground-motion models in terms of their mean values and standard deviations for peak ground accelerations and Fourier amplitude spectral values.
CONCEPT OF JUDICIAL REFORM IN RUSSIA AND SPECIAL ASPECTS OF CRIMINAL PROCEDURE POLICY OF THE STATE
Authors: Kirillova N. P. 
Published: December 2022

The article concerns with the analysis of the results of realization
of the Concept of judicial reform and particularities of the state
criminal procedure policy relating to the implementation of the
criminal procedure policy regarding the preliminary investigation
policy and the courts activity. The author assesses the status of
criminal procedural law governing the preliminary investigation
and prosecutors supervision, considering the value and results of
implementation of judicial control at the stage of preliminary
investigation, its positive and negative sides. In the article the
shortcomings of procedural regulation of simplified procedural forms
are pointed out and ways of improving legislation are suggested.
Growth and Productivity of Chickpea (Cicer arietinum L.) Varieties as Influenced by Seed Rate and Nipping in the Irrigated Arid Western Plain Zone
Authors: Choudhary Ashok , Shekhawat P.S. , Godara A.S. , Singh S.P. , Kumar Sheilendra 
Published: December 2022

Background: Chickpea plays a greater role in national food and nutritional security and sustaining the economy of the farming community in a variety of ways. As a result of stagnated production and continuous increasing in population, the per capita availability of pulses has decreased considerably. Since very little scope exists for horizontal expansion of area, the alternative seems to be by adopting innovative agronomic practices like nipping, selection of proper seed rate and variety for a set of agro-climatic conditions to overcome from decreasing production potential. In view of above consideration, the present investigation entitled “Response of seed rate and nipping on different chickpea (Cicer arietinum L.) varieties in arid irrigated western plain zone” was carried out. Methods: The field experiment was conducted at SKRAU, Bikaner during two consecutive Rabi seasons of 2016-17 and 2017-18. The experiment was laid out in split-plot design with three replications, assigning 36 treatments consisting of three varieties (GNG-1581, GNG-1958 and GNG-2171) and three seed rates (48, 64 and 80 kg/ha) as main plot treatments and four levels of nipping practice (control, nipping at 30, 45 and 60 DAS) as subplot treatments. Result: Variety GNG-1581 had significantly shorter plant stature with higher number of branches/plant (13.94), pods/plant (40.14), seeds/pod (1.78), seed yield (2142 kg/ha), whereas, variety GNG-1958 showed significantly higher plant height (52.53 cm) and straw yield (3720 kg/ha). Number of branches per plant, number of pods per plant and seed index were found significantly higher in the seed rate of 48 kg/ ha. Maximum plant population, plant height, seed yield (2111 kg/ha.), straw yield (3657 kg/ha) were recorded with the seed rate of 80 kg/ ha but on par with the seed rate of 64 kg/ha. Nipping had a significant effect on growth, yield attributes and yield of chickpea. The highest number of branches/plant (13.32), pods/plant (39.61), seed/pod (1.78), seed index (19.16 g), seed yield (2121 kg/ha) and straw yield (3695 kg/ha) were obtained when nipping was practiced at 45 DAS.
A content analysis of master and doctorate thesis in the area of gamification
Authors: Uzunboylu Huseyin , Kocakoyun Senay 
Published: December 2022

Abstract
This study is a content analysis of thesis related with gamification area in Higher Education Council (YOK) Thesis Center database. It was figured out that the first thesis related with gamification concept was published in 2014 in YOK Thesis Center and a total number of 9 thesis were obtained by the end of 2015. It was revealed that 8 of these theses are master thesis and 1 of them is doctorate thesis. It was also figured out that thesis are mostly studied in Institute of Social Sciences. â€œEducation and Instructionâ€, â€œscience and technologyâ€, â€œcomputer and controlâ€ and â€œadvertising/communication sciencesâ€ are frequently studied in the area of gamification as research subjects. When thesis is examined, it was determined that studies in the area of gamification are yet at the beginning of the road. Furthermore, it could be indicated that gamification will be an inseparable part of further research and application and usage area of gamification will be expanded in the future as well.
Keywords: gamification, research trends, content analysis
Simultaneous Displaced Anterior and Posterior Cruciate Ligament Avulsion Fractures After Fall From a Bicycle
Authors: Berrian Kaitlyn M. , Lee Patrick , Issack Paul S. 
Published: December 2022

Case:
We present the case of a 31-year-old man who sustained simultaneous displaced anterior and posterior cruciate ligament (PCL) tibial avulsion fractures after falling from a bicycle.

Conclusion:
Combined avulsion fractures of the anterior and PCLs is an extremely unusual event and has rarely been reported. The displaced fragments pulled proximally by their respective cruciate ligaments required open reduction and internal fixation to prevent impingement and instability. The patient had excellent clinical and radiographic results after open reduction internal fixation of both fractures.
Barform deposits of the Carolyn Shoemaker formation, Gale crater, Mars
Authors: Cardenas Benjamin T. , Grotzinger John P. , Lamb Michael P. , Lewis Kevin W. , Fedo Christopher M. , Bryk Alexander B. , Dietrich William E. , Stein Nathan , Turner Madison , Caravaca Gwénaël 
Published: December 2022

ABSTRACT
The early environmental history of Mars is encoded in the planet's record of sedimentary rocks. Since 2012, the Curiosity rover has been ascending Mount Sharp, Gale crater's central mound, making detailed observations of sedimentary strata exposed there. The primary depositional setting represented by the rocks examined thus far has been a perennial lake, represented by the mudstones and sandstone lenses of the Murray formation. Here, we report on the sedimentology of outcrops examined in the Carolyn Shoemaker formation, which sits stratigraphically above the Murray formation. We interpret strata exposed in the Glasgow and Mercou members of the Carolyn Shoemaker formation to represent river bars in ancient alluvial and shoreline settings based on sedimentary structures, stratal geometries measured from photogrammetric data, and erosional morphology. The transition from a lacustrine to a fluvial depositional setting records the aggradation and progradation of coastal rivers into what was previously the extent of the Gale lake system. This may have occurred due to the shrinking of the lake over time due to climate-driven changes in the basin water balance, or local three-dimensionality in shoreline evolution, such as the formation of a new sedimentary lobe following a channel switch.
Prognostic evaluation based on dual time 18F-FDG PET/CT radiomics features in patients with locally advanced pancreatic cancer treated by Stereotactic Body Radiation Therapy
Authors: Wang Fei , Cheng Chao , Wu Zhongyi , Wang Tao , Zuo Changjing , Yan Zhuangzhi , Liu Zhaobang 
Published: December 2022

Abstract
Background: 18F-FDG PET/CT is widely used in the prognosis evaluation of tumor patients. The radiomics features can provide additional information for clinical prognostic assessment.
Purpose: To explore the prognostic value of radiomics features from dual time 18F-FDG PET/CT images for locally advanced pancreatic cancer (LAPC) patients treated with stereotactic body radiation therapy (SBRT).
Materials and Methods: This retrospective study included 70 LAPC patients who received early and delayed 18F-FDG PET/CT scans before SBRT treatment. A total of 1188 quantitative imaging features were extracted from dual time PET/CT images. To avoid over-fitting, the univariate analysis and elastic net were used to obtain a sparse set of image features, that were applied to develop a radiomics score (Rad-score). Then the Harrell consistency index (C-index) was used to evaluate the prognosis model.
Results: The Rad-score from dual time images contains six features, including intensity histogram, morphological, and texture features. In the validation cohort, the univariate analysis showed that the Rad-score was the independent prognostic factor (p<0.001, hazard ratio [HR]: 3.2). And in the multivariate analysis, the Rad-score was the only prognostic factor (p < 0.01, HR: 4.1) that was significantly associated with the OS of patients. In addition, according to cross-validation, the C-index of the prognosis model based on the Rad-score from dual-time images is better than the early and delay images (0.720 vs 0.683 vs 0.583).
Conclusion: The Rad-score based on dual-time 18F-FDG PET/CT images is a promising non-invasive method with better prognostic value.
Imperialist Competitive Algorithm for Subcontractor Selection in Multiple Project Environments
Authors: Afshar Mohammad Reza 
Published: December 2022

Abstract
In the current study, Imperialist Competitive Algorithm (ICA) is presented to solve subcontractor selection problem (SSP) in multiple project environments with minimization of general contractor's cost as the objective subject to resource and precedence constraints under two different circumstances. In the first circumstance, the project deadline can be postponed by paying a penalty. While, in the second one, the deadline cannot be postponed. The Random Key (RK) and the subcontractor list representation schemes are employed as encoding procedures and the serial schedule generation scheme (SSGS) is utilized as decoding scheme. Comparing the results of the presented ICA with an exact method and also a Genetic algorithm (GA) utilizing a real case study validates the effectiveness of the proposed algorithm to solve SSP in multiple project environments. The outcomes demonstrate that the proposed ICA is more efficient in the presence of a strict deadline.
Uncertainty on Estimated Magnitudes: A New Approach based on a Point Poisson Process of Dimension 2
Authors: DUTFOY Anne 
Published: December 2022

Abstract
The magnitudes recorded in seismic catalogues are subject to uncertainties that can have a significant impact when estimating the parameters of seismic recurrence models. In this paper, we propose an innovative approach based on a Poisson point process of dimension 2 that models both the magnitude hazard and the associated uncertainty. We define estimators of the parameters of the Gutenberg Richter (a, b) model that maximize the likelihood of the data with respect to the model. We apply the approach to the Alps region in France and compares it to other approaches proposed in the literature.
Transboundary cooperation in infrastructure operation generates economic and environmental co-benefits to the Lancang-Mekong River Basin
Authors: Yu Yang , Bo Yan , Castelletti Andrea , Dumas Patrice , Gao Jinyu , Cai Ximing , Liu Junguo , Kahil Taher , Wada Yoshihide , Liu Bo , Zhou Feng , Zhao Jianshi 
Published: December 2022

Abstract

The Lancang-Mekong River basin (LMRB) is facing blooming water resources infrastructure development, long-term transboundary conflicts and trade-offs between economic goals and ecosystem services provision. Yet, most studies optimizing the pathway towards sustainable infrastructure operation have lacked multi-sectoral and cross-country perspectives. Here, we quantify how and to what extent transboundary cooperation generate economic and environmental co-benefits by jointly using a coupled simulation-optimization approach and cooperative game theoretical analysis. We find that full cooperation outweighs non- or partial cooperation modes to promote economic benefits by 5 to 27%, and to minimize the losses in fishery and sediment transport from 14% and 33% to 8% and 10%, respectively. Full cooperation becomes more beneficial and stable alongside infrastructure expansion, climate change, and the degree of satisfying hydrological needs for river ecosystems. These findings underscore the importance of full cooperation for sustaining socio-environmental systems and highlight the needs of benefit reallocation mechanism and designed flow management for stabilizing basin-level full cooperation in the LMRB.
Grow Newtonian rigid inertia into parameter repetitiveness memory equivalent bio-inertia over the “super-simultaneousness” of quantum mechanics for growth turnover selection inheritance
Authors: Lai Yi Yu 
Published: December 2022

Abstract
Inversion energy is defined as parameter-against-gravity-internal-fluctuation, the non-simultaneousness in correlated internal fluctuations is quantizing time. Modified Newtonian Three Laws are, first: \(\frac{d}{dx}\)cosx =\(-sinx,\) \(\frac{d}{dx}\)sinx =\(cosx\); second: \(\overrightarrow{F}=m\bullet \overrightarrow{a}\) + \(\left|m\overrightarrow{g}\int tg\theta \cdot d\theta ⟩\right.\upharpoonleft \downharpoonright\); third: Wavelength = \(\frac{2}{n}\)L, frequency = n\({f}_{0}\). Bio-systems are topological spaces that can process input objects into inversion energy for entropy-control by repetitiveness memory, the capability of equivalent procured inversion energy with memorized trigonometric repetitiveness by quantizing time is bio-inertia. Evolution grows the trigonometric folding equivalent capacity of a topological space. Schrödinger equation has only quantized energy but hasn’t quantized time thus inducing quantum collapse. We then define in vivo conditions to grow over the “super-simultaneousness” of conventional quantum to reverse collapse for lifespan. Originating from bio quantum scale differences between Planck regions and surface tension regions, bio quantum duality grows in vivo cross folded-surface tension region flow. Life relies on trigonometric negentropy procured from elastic entropy generation ground states and physically inherit by bio quantum growth turnover selection.