bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecological and human health risk assessment of heavy metal in sediment and demersal marine fish in Gulf of Guinea western offshore Nigeria
Authors: Sule Abiodun Yusuf , Yakub Ademola Semiu , Agwu Ogochukwu Angela , Bassey Bassey Okon , Igbo Juliet Kelechi , Bello Beatrice Omolola , Abiodun Olushola Ayoola , Olapoju Oluwabukunola Ayokunmi , Nosazeogie Esther Osayevbovban , Izge Musa Abdullahi , Haruna Adedamola Faidat 
Published: June 2022

Abstract
This study was focused to assess contamination status of heavy metals in sediments, and human health risk associated with fish consumption from western Nigerian offshore in the Gulf of Guinea. Fish stock assessments were carried out across five fishing grounds. Triplicate samples of demersal marine fish species and sediments were collected and analysed for heavy metals (mercury- Hg, cadmium- Cd, lead- Pb and Arsenic- As) by ICP-OES (inductively coupled plasma optical emission spectrometry) using US EPA 200.7 standard method. The geospatial variation of As and Hg revealed that the concentrations were relatively highest at station 1, while Cd and lead Pb concentrations were highest at station 3. Levels of heavy metal in sediment fell below sediment quality guidelines (SQG). While, metal concentrations (As, Cd, Hg and Pb) in demersal marine fish also fell within the permissible levels of FAO/WHO. The ecological indices [Probable contamination index (PCI), mean effect level quotients, newly modified hazard quotient and Hazard quotient (HQ)] indicated low contamination level of heavy metals in sediment. Hazard index (HI) of metals in fish species associated with human health were within recommended threshold of 1 and thus revealed that there would be no significant health risk to the consumers. Percentage of total variance for PC1 is 52.26% whereas PC2 is 27.56% showed weak loading of metals. The study established scientific basis for assessment of metal contamination and risk management of food safety within the western Nigerian offshore waters.
Circular RNA-Encoded MET Variant Is a Targetable Factor in Glioblastoma
Authors: Zhong Jian , Wu Xujia , Chen Junju , Gao Yixin , Zhang Maolei , Zhou Huangkai , Yang Jia , Xiao Feizhe , Yang Xuesong , Huang Nunu , Wang Xiuxing , zhang Nu 
Published: June 2022

Abstract
Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase MET is pivotal in promoting glioblastoma stem cell (GSC) self-renewal, invasiveness and tumorigenicity. Nevertheless, HGF/MET-targeted therapy has shown limited clinical benefits in glioblastoma patients, suggesting hidden mechanisms of MET signalling in glioblastoma. Here, we show that circular MET RNA (circMET) encodes a 404 amino acid novel MET variant (MET404) facilitated by the N6-methyladenosine (m6A) reader YTHDF2. Genetic ablation of circMET inhibited MET404 expression in mice and attenuated MET signalling. Conversely, MET404 knock-in plus P53 knock-out in mouse astrocytes initiated glioblastoma tumorigenesis and shortened overall survival. MET404 directly interacts with the MET β subunit and forms a constitutively activated MET receptor whose activity does not require HGF stimulation. High MET404 expression predicts poor prognosis in glioblastoma patients, indicating its clinical relevance. Targeting MET404 through a neutralizing antibody or genetic ablation reduced glioblastoma tumorigenicity in vitro and in vivo, with combinatorial benefits when a traditional MET inhibitor was added. Overall, we identified a novel MET variant that promotes glioblastoma tumorigenicity, offering a potential new therapeutic strategy for glioblastoma.
The therapeutic antischizophrenic activity of prodigiosin and selenium co-supplementation against amphetamine hydrochloride-induced behavioural changes, oxidative, inflammatory, and apoptotic challenges in rats
Authors: Alsharif Khalaf F , Albrakati Ashraf , omairi Naif E. Al , Almalki Abdulraheem S. , Alsanie Walaa , Elmageed Zakaria Y. Abd , Habotta Ola A. , Lokman Maha S. , Althagafi Hussam A. , Alghamdi Abdullah A. A. , Moneim Ahmed E. Abdel , Alyami Hussain , Belal Saied K. , Alnefaie Ghaliah , Alamri Abdulhakeem S. , Albezrah Nisreen Khalid Aref , Kassab Rami B. , Albarakati Alaa Jameel A. , Hassan Khalid Ebraheem , Agil Ahmad 
Published: June 2022

Abstract
Schizophrenia (SCZ), a multifactorial neuropsychiatric disorder, is treated with inefficient antipsychotics and linked to poor treatment outcomes. This study, therefore, investigated the combined administration of prodigiosin (PDG) and selenium (Na2SeO3) against SCZ induced by amphetamine (AMPH) in rats. Animals were allocated into four groups corresponding to their respective seven-day treatments: control, AMPH (2 mg/kg), PDG (300 mg/kg) + Na2SeO3 (2 mg/kg), and AMPH + PDG + Na2SeO3. The model group exhibited biochemical, molecular, and histopathological changes similar to those of the SCZ group. Contrastingly, co-administration of PDG and Na2SeO3 significantly increased the time for social interaction and decreased AChE and dopamine. It also downregulated the gene expression of NMDAR1 and restored neurotrophin (BDNF and NGF) levels. Further, PDG combined with Na2SeO3 improved the antioxidant defence of the hippocampus by boosting the activities of SOD, CAT, GPx, and GR. These findings were accompanied by an increased GSH, alongside decreased MDA and NO levels. Furthermore, schizophrenic rats having received PDG and Na2SeO3 displayed markedly lower IL-1b and TNF-α levels compared to the model group. Interestingly, remarkable declines in the Bax (pro-apoptotic) and increases in Bcl-2 (anti-apoptotic) levels were observed in the SCZ group that received PDG and Na2SeO3. The hippocampal histological examination confirmed these changes. Collectively, these findings show that the co-administration of PDG and Na2SeO3 may have a promising therapeutic effect for SCZ. This is mediated by mechanisms related to the modulation of cholinergic, dopaminergic, and glutaric neurotransmission and neurotrophic factors, alongside the suppression of oxidative damage, neuroinflammation, and apoptosis machineries.
Reasons of women who undergone repeat induced abortion; in Wolaita Sodo town, Southern Ethiopia, 2021: A phenomenological qualitative study
Authors: Bantero Kibrework Bezabih , Deressa Jembere Tesfaye , Tilahun Sosina Workineh , Kitawu Leul Deribe 
Published: June 2022

Abstract
Background
Repeat induced abortion refers to a condition in which a woman has at least one previous history of induced pregnancy termination. It bound in a vicious cycle with repeat unintended or unplanned pregnancy and remains rising concern, particularly for developing countries.
Objectives
This study was aimed to explore reasons and lived experiences of women, who undergone repeat induced abortion; in Wolaita Sodo town, Southern Ethiopia.
Methods and Materials:
A phenomenological qualitative study approach was conducted from February 15-March 22, 2021 among women in Wolaita Sodo town. Twelve women between 17 and 35 years old, who had at least one previous abortion were selected using purposive sampling. In-depth interview using semi-structured interview guide was conducted. Data were audio recorded, transcribed verbatim and translated in to English and imported to ATLAS.ti8 software for coding. Code book development, peer debriefing, multiple coders and audit trials applied to maintain rigor of the data and analysis was done deductively.
Result
The study found reasons of repeat induced abortion among women at maternal, partner and family, healthcare and educational institution, community and policy level. It also looked into the effects of induced abortion from the standpoint of women. Economic issues, fears about contraceptive side effects, and a desire to limit the number of children were stated as reasons.
Conclusion
Study revealed multiple reasons for repeat induced abortion in holistic manner; and presented key emotional and physical effects of abortion and unintended pregnancy. Based on the findings, multiple interventions at individual, community and organizational levels; and strong law enforcement on criminals of rape are needed in order to avoid or minimize the reasons and negative consequences of repeat induced abortion.
Parent and Adolescent Intuitive Eating Behavior: Associations with Weight Change During Family-Based Treatment for Anorexia Nervosa
Authors: Nelson Jillian D. , Trojanowski Paige J. , Peterson Claire M. , Fischer Sarah , Matthews Abigail 
Published: June 2022

Abstract
Purpose
Intuitive eating (IE) is an adaptive eating construct for which little research exists in eating disorder (ED) samples. IE is negatively correlated with disordered eating behaviors in healthy adolescents and adults, and similar associations have been found in adults with EDs. This study aims to examine IE in a treatment seeking sample of adolescents and their parents to understand its role in weight gain during FBT.
Methods
Descriptive statistics and bivariate correlations were calculated in a sample of 47 pairs of adolescent patients and their parents who initiated outpatient FBT at a large academic medical center. Analyses examined parent and adolescent IE, weight gain at session 4 and end of treatment (EOT), clinical impairment, and eating disorder pathology.
Results
Significant correlations were found between aspects of adolescent IE, ED symptoms, and clinical impairment. Aspects of parent IE were negatively related to their child’s weight and shape concerns, and Global EDE-Q score at baseline. Parent IE (Eating for Physical rather than Emotional Reasons) was positively associated with adolescent weight gain at session 4 and EOT.
Conclusion
Study results were consistent with past research indicating adolescent IE is negatively associated with ED behaviors, cognitions, and impairment. This study is the first to provide evidence that parent IE is positively associated with adolescent weight gain in FBT, and is the first to provide evidence that parent IE is negatively related to adolescent ED symptoms. Future research should examine adolescent and parent IE throughout FBT to understand its role in treatment response.
The Color of Water: Racial Differences in Exposure to Flood Risk across the U.S.
Authors: Galster George C. , Galster Joshua C , Vachuska Karl 
Published: June 2022

Abstract
Previous studies on distributive environmental justice issues related to flooding exposure have been limited in spatial scale, afflicted by measurement shortcomings, and inconsistent in findings. We provide the first U.S. national and state-by-state descriptive portrait of annual average exposure to floods across all Census-defined racial/ethnic groups. Specifically, we investigate whether there are statistically significant interracial differences in average annual probabilities of experiencing a flood in the U.S. and how these differences vary across states and coastal vs. inland areas. We use predictions from the recent First Street Foundation flooding exposure model and demographic data from the US Census Bureau American Community Survey in our analysis. We observe no states in which non-Hispanic Blacks have a (statistically) significantly higher average exposure to floods than non-Hispanic Whites, but 21 states where the reverse is true. Hispanics have a significantly higher average exposure in three states, and a significantly lower average exposure in 18 states, compared to Whites. Notably, however, the aggregate Hispanic population of the three states where Hispanics face greater flood exposure (Illinois, Massachusetts, and Texas) exceeds the aggregate Hispanic population of the 18 where their average exposures are lower than Whites’. There are eight states in which Native Americans have significantly higher exposure, and none where have lower exposure than Whites’, implying that additional research and appropriate, community-informed policy responses should focus on this group. Further studies are also needed at smaller spatial scales to identify communities of color facing disproportionate flood exposures.
Circulating Tumor Cells Correlates with Adverse Outcomes for Non-metastatic Colorectal Cancer Patients Both Before and After Surgery
Authors: Lin Chun-Chi , Yang Chih-Yung , Hung Tzu-Chao , Wang Chun-Hung , Wei Sheng-Wen , Schiro Perry G. , Tseng Ju-Yu , Lin Chi-Hung , Jiang Jeng-Kai 
Published: June 2022

Abstract
Circulating tumor cells (CTCs) in blood have been accepted as a prognostic marker in patients with metastatic colorectal cancer (CRC). However, there is limited reported data on the use of CTCs as a prognostic marker for non-metastatic patients. In the current study, we used a rare cell automated analysis platform, the MiSelect R System, to enumerate CTCs from blood in non-metastatic CRC patients, and corelated the number of CTCs with the clinical staging and survival. The presence of CTCs in mesenteric vein blood (MVB) samples from 101 CRC patients was significantly associated with T stage. Patients with 1 or more CTCs per 8 mL of MVB exhibited significantly worse disease-free survival (DFS) and cancer-specific survival (CSS) compared to patient without CTCs. The presence of CTC before surgery is an independent marker for both DFS and CSS. CTC presence after surgical resection is also a prognostic marker. CTCs are a potentially useful prognostic and predictive biomarker in non-metastatic CRC patients that may help to further stratify patient’s risk status within different stages of disease.
County-level ammonia emissions monitored worldwide
Authors: Dammers Enrico , Shephard Mark , Griffin Debora , Chow Evan , White Evan , Hickman Jonathan , Tokaya Janot , Lutsch Erik , Kharol Shailesh , Graaf Shelley van der , Cady-Pereira Karen , Bittman Shabtai , McLinden Chris , Erisman Jan Willem , Schaap Martijn 
Published: June 2022

Abstract
Ammonia is a form of reactive nitrogen whose emissions are primarily from livestock excreta and crop fertilisation. Atmospheric ammonia is a major source of anthropogenic aerosols, and can negatively impact both human and ecosystem health. Despite its importance, rates of ammonia emission remain highly uncertain at all spatial scales, local to global. Here we use satellite ammonia observations to produce the first global observation-based, county-level annual rates of ammonia emissions. We find that previously reported ammonia emissions tend to be under-estimated over large parts of the globe. Global satellite-based emission totals are 1.8 times greater than in previously reported anthropogenic locations, and 4 times greater when newly detected anthropogenic and natural sources are included. Countries with ammonia regulations in place (e.g. European Union) tend to show a much better comparison to reported emissions. In addition to quantifying ammonia emissions and their spatial distribution, our satellite-based methodology provides a globally consistent emissions database that is not subject to offsets and gaps across geopolitical borders. With ammonia emissions expected to rise in the future due to increasing demands to feed the growing world population, there is a growing need for timely monitoring of ammonia emissions at a county-level worldwide to support mitigation policies.
Investigation of the Relationship Between Early Maladaptive Schemas, Temperament and Eating Attitude in Adults
Authors: Güler Kahraman , Özgörüş Zeynep 
Published: June 2022

Abstract
Background: This study aimed to examine the relationship between early maladaptive schemas, temperament, eating attitude and the effect of gender variable on these concepts in adults. Methods: The sample group consists of a total of 308 participants, 206 (66.9%) women and 102 (33.1%) men, living in Bursa and participating in the research voluntarily. In the study, Sociodemographic Data Form was used to obtain personal information of the participants, Young Schema Questionnaire - Short Form 3 (YSQ-SF3) was used to evaluate early maladaptive schemas, Temperament Evaluation of Memphis, Pisa, Paris and San-Diego Autoquestionnaire (TEMPS-A) was used to evaluate temperament characteristics and Eating Attitude Test was used to evaluate eating attitudes. Results: As a result of the study, a moderate and positive relationship was found between the Defectiveness, Emotional Inhibition, Enmeshment/ Dependence, Failure, Abandonment, Vulnerability to Harm or Illness, Negativity/ Pessimism schemas and eating attitude. Among these schemas, Defectiveness was found to be the best predictor of deterioration in eating attitude. A weak and positive relationship was found between the scores obtained from the Eating Attitude Test and Cyclothymic and Irritable temperaments, and a moderate positive relationship with Anxious temperament. Among these temperaments, Anxious temperament was found to be the best predictor of deterioration in eating attitude.Conclusions: When the results were examined, a relationship was observed between early maladaptive schemas and temperament types, and this relationship was examined in detail. The results obtained at the end of the study were discussed and suggestions were made for future studies.
The vaginal and uterine blood flow changes during the ovsynch program and its impact on the pregnancy rates in Holstein dairy cows
Authors: Sharawy Heba , Hegab AbdelRaouf , Risha Engy , Adl Mohamed El , Soliman Walid , Gohar Mohamed , Fahmy Reham , Farag Virginia , Imakawa Kazuhiko , Bazer Fuller , James Daniela , Zaghloul Adel , Abdalla Abdelnasser , Rabie Mariam , Elmetwally Mohammed 
Published: June 2022

Abstract
Aim
OvSynch is a hormonal protocol for synchronization of estrus and use of artificial insemination (AI) at an optimal time without adverse effects on the ovaries or uterus. This study investigated the use of noninvasive color Doppler ultrasound to assess changes in uterine and vaginal blood flow during the Ovsynch program for synchronization of estrus and its relation to the pregnancy rates in Holstein cows.
Materials and methods
The experimental cows received an intramuscular dose of 10 µg of a GnRH analogue (G1), followed 7 days later with an intramuscular injection of synthetic prostaglandin F2α (P: PGF2α) analogue (500 µg cloprostenol sodium), and given a 10 µg, injection of the GnRH analogue (G2) i.m. (2.5ml/animal) 48 h after the PGF2a treatment, and the cows were bred 14–16 h after. Uterine and vaginal perfusion were investigated by performing transrectal Doppler ultrasonography of both the middle uterine and vaginal arteries in Holstein cows at different time points during the Ovsynch program to determine: peak systolic velocity (PSV), time-averaged maximum velocity (TAMV), the volume of blood flow (BFV), pulsatility index (PI), resistance index (RI), resistance impedance (S/D) and diameters of uterine (UA) and vaginal (VA) arteries. Steroid hormones were also considered. Transrectal ultrasonography (TUS) was performed at 32 and 60 days to confirm the pregnancy per artificial insemination (P/AI).
Results
The uterine PSV, TAMV, and PV were greater at the time of the cloprostenol sodium and second GnRH injections (p < 0.05) than at the time of the first GnRH injection. The vaginal PSV, PV were greater at the time of the cloprostenol sodium than at the time of the first and second GnRH injections (p < 0.05). The receiver operating characteristic curve (ROC curve) indicated a higher correlation between the uterine and vaginal blood flow and the rate of the pregnancy (p < 0.05). The ROC curve for the vaginal artery was 0.920 and that for uterine blood flow was 0.870 (p < 0.05) at the G2 (p < 0.05). The serum levels of progesterone, estrogen and cortisol were correlated with the P/AI (p < 0.05). The P/AI significantly decreased from 43.9% at 32 d to 35.37% at 60 d.
Conclusion
These results indicate that noninvasive Doppler ultrasonography is a valid method to evaluate changes in the characteristics of uterine and vaginal blood flow in cows during the Ovsynch protocol. Furthermore, vaginal and uterine blood flow are two determinant factors for the higher conception rates in Holstein dairy cows.
Barriers and facilitators to training delivery and subsequent implementation of a localised child and adolescent mental health initiative: A qualitative content analysis
Authors: Banwell Emily , Qualter Pamela , Humphrey Neil 
Published: June 2022

Abstract
Background:Ensuring that children and young people (CYP) can obtain mental health support from a broad variety of sources is of upmost importance. This is especially true given the increasing prevalence of mental health difficulties in this population, and the associated challenges with receiving support from specialised healthcare services. Equipping professionals, from a wide range of sectors, with the skills needed to provide this support is a vital starting point. This study explored the experiences of professionals who had participated in CYP mental health training modules relating to a socially funded initiative in Greater Manchester, UK, to establish the barriers and facilitators behind its implementation.Methods:Directed qualitative content analysis of semi-structured interview data from nine CYP-facing professionals was conducted. Both interview schedule and initial deductive coding strategy were devised using the findings of a relevant systematic literature review by the authors. This methodology was used with the aim of establishing the presence of these findings within the localised intervention, before generating tailored recommendations for their training programme.Results:When the interview data were coded and analysed, a strong level of thematic similarity with the authors’ review was found. However, we deduced that the emergence of additional inductive themes might reflect the contextual uniqueness of the intervention, in addition to that of the COVID-19 pandemic. Six recommendations were made for further improvement of CYP mental health training, including the facilitation of unstructured peer interaction during training, and ensuring that jargon and key words are fully clarified. Conclusions:Methodological limitations, guidance for usage, and potential applications of the study’s findings are explored. Whilst largely, the findings were akin to those of the review, subtle yet important differences were found. These are likely to reflect the nuances of the training programme discussed, but despite this, we tentatively suggest that our findings are transferable to similar training interventions. This study provides a valuable example of how qualitative evidence syntheses can be used to aid study design and analysis: an underused approach.
Design and Analysis of a Novel MEMS Touch Mode Convex Capacitive Pressure Sensor for Altimeter Applications
Authors: K SREEKANTH P , JINDAL SUMIT KUMAR 
Published: June 2022

Abstract
The wide applications of Touch Mode Capacitive Pressure Sensors (TMCPS) have led the researchers working
more on its performances. TMCPS have more acceptance due to its linearity, sensitivity, and ability to withstand more pressure which make them suitable for harsh environments. This study proposes a novel convex shape substrate to further improve the response of the TMCPS. This work provides a detailed mathematical and analytical modelling which upholds the proposed design. The analysis is compared with the simulation results from the software MATLAB. The simulated results has been compared with those reported in the existing literature. The linear operation
range of the sensor is stretched more on the lower side (88 KPa– 2 MPa) and the sensitivity is improved 2.85 times in touch mode, which completely fits in for the altimeter applications. Sensor system characteristics such as non-linearity, hysteresis, temperature dependence etc is also calculated in this work. The presented theory and simulation analysis fully supports the superior performance of the novel convex substrate square diaphragm TMCPS.