bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Magnetic Resonance Imaging Outcomes After Microfracture Treatment With and Without Augmentation for Focal Chondral Lesions in the Knee: A Systematic Review and Meta-analysis
Authors: Fortier Luc M. , Knapik Derrick M. , Dasari Suhas P. , Polce Evan M. , Familiari Filippo , Gursoy Safa , Chahla Jorge 
Published: June 2022

Background: Focal cartilage lesions represent a common source of knee pain and disability, with the potential for the development and progression of osteoarthritis. Currently, microfracture (MFx) represents the most utilized first–line surgical treatment for small, focal chondral lesions. Recent investigations have examined methods of overcoming the limitations of MFx utilizing various augmentation techniques. Purpose: To perform a systematic review and meta–analysis evaluating clinical and radiographic outcomes in patients undergoing isolated MFx versus MFx augmented with orthobiologics or scaffolds for focal chondral defects of the knee. Study Design: Systematic review and meta-analysis; Level of evidence, 4. Methods: A systematic review was performed to identify studies evaluating outcomes and adverse events in patients undergoing isolated MFx versus augmented MFx for focal chondral defects in the knee from 1945 to June 1, 2021. Data were extracted from each article that met the inclusion/exclusion criteria. Meta-analyses were performed for all outcomes reported in a minimum of 3 studies. Results: A total of 14 studies were identified, utilizing 7 different types of injectable augmentation regimens and 5 different scaffolding regimens. Across the 14 studies, a total of 744 patients were included. The mean patient age was 46.8 years (range, 34-58 years), and 58.3% (n = 434/744) of patients were women. The mean final follow–up time was 26.7 months (range, 12-60 months). The mean chondral defect size ranged from 1.3 to 4.8 cm2. A post hoc analysis comparing mean improvement in postoperative outcomes scores compared with preoperative values found no significant differences in the improvement in the visual analog scale (VAS), International Knee Documentation Committee (IKDC), or Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores between patients undergoing isolated MFx and those undergoing MFx + augmentation. Patients undergoing MFx + augmentation reported significantly greater improvements in the Lysholm score and postoperative MOCART (magnetic resonance observation of cartilage repair tissue) scores compared with the isolated MFx group. Conclusion: Patients undergoing combined MFx + augmentation reported significant improvements in mean Lysholm and MOCART scores, without significant improvements in VAS, IKDC, or WOMAC scores when compared with patients undergoing isolated MFx.
Tissue engineering application combining epoxidized natural rubber blend and mesenchymal stem cells in in vivo response
Authors: Henckes Nicole Andréa Corbellini , Chuang Laura , Bosak Isadora , Carazzai Rafael , Garcez Tuane , Kuhl Cristiana Palma , de Oliveira Fernanda dos Santos , Loureiro dos Santos Luis Alberto , Visioli Fernanda , Cirne-Lima Elizabeth Obino 
Published: June 2022

This study aimed to investigate biocompatibility, integration, and tissue host response of the Poly (Lactic-co-Glycolic acid) (PLGA)/Poly (isoprene) (PI) epoxidized (PLGA/PIepox) innovative scaffold combined with adipose derived mesenchymal stem cells (ADSC). We implanted the scaffold subcutaneously on the back of 18 female rats and monitored them for up to 14 days. When compared to controls, PLGA/PIepox + ADSC demonstrated an earlier vascularization, a tendency of inflammation reduction, an adequate tissue integration, higher cell proliferation, and a tendency of expression of collagen decreasing. However, 14 days post-implantation we found similar levels of CD31, Ki67 and AE1/AE3 in PLGA/PIepox when compared to control groups. The interesting results, lead us to the assumption that PLGA/PIepox is able to provide an effective delivery system for ADSC on tissue host. This animal study assesses PLGA/PIepox + ADSC in in vivo tissue functionality and validation of use, serving as a proof of concept for future clinical translation as it presents an innovative and promising tissue engineering opportunity for the use in tissue reconstruction.
Altered functional brain states predict cognitive decline 5 years after a clinically isolated syndrome
Authors: Koubiyr Ismail , Broeders Tommy AA , Deloire Mathilde , Brochet Bruno , Tourdias Thomas , Geurts Jeroen JG , Schoonheim Menno Michiel , Ruet Aurélie 
Published: June 2022

Background: Cognitive impairment occurs in the earliest stages of multiple sclerosis (MS) together with altered functional connectivity (FC). Objective: The aim of this study was to investigate the evolution of dynamic FC states in early MS and their role in shaping cognitive decline. Methods: Overall, 32 patients were enrolled after their first neurological episode suggestive of MS and underwent cognitive evaluation and resting-state functional MRI (fMRI) over 5 years. In addition, 28 healthy controls were included at baseline. Results: Cognitive performance was stable during the first year and declined after 5 years. At baseline, the number of transitions between states was lower in MS compared to controls ( p = 0.01). Over time, frequency of high FC states decreased in patients ( p = 0.047) and increased in state with low FC ( p = 0.035). Cognitive performance at Year 5 was best predicted by the mean connectivity of high FC state at Year 1. Conclusion: Patients with early MS showed reduced functional network dynamics at baseline. Longitudinal changes showed longer time spent in a state of low FC but less time spent and more connectivity disturbance in more integrative states with high within- and between-network FC. Disturbed FC within this more integrative state was predictive of future cognitive decline.
Sound generated by axisymmetric non-plane entropy waves passing through flow contractions
Authors: Yang Dong , Guzmán-Iñigo Juan , Morgans Aimee S. 
Published: June 2022

For a single-component perfect gas, entropy perturbations are associated with the difference between the overall density fluctuation and that coming from the acoustic perturbation. Entropy perturbations can generate sound when accelerated/decelerated by a non-uniform flow and this is highly relevant to thermoacoustic instabilities for gas turbines and rocket engines, and to noise emission for aero-engines. Widely used theories to model this entropy-generated sound rely on quasi-1D assumptions for which questions of validity were raised recently from both numerical and experimental studies. In the present work, we build upon an acoustic analogy theory for this problem. This theory was initiated by Morfey (J. Sound Vib. 1973) and Ffowcs Williams and Howe (J. Fluid Mech. 1975) about 50 years ago and extended recently by Yang, Guzmán-Iñigo and Morgans (J. Fluid Mech. 2020) to study the effect of non-plane entropy waves at the inlet of a flow contraction on its sound generation. Comparisons against both numerical simulations and previous theory are performed to validate the results.
Fusion Imaging Guidance Does Not Affect Radiation Exposure During Endovascular Procedures for Lower Extremity Arterial Disease: A Randomized Controlled Trial
Authors: Postaire Boris , Nasr Bahaa , le Corvec Tom , Brisard Laurent , Chaillou Philippe , Guyomarch Béatrice , Fellah Imen , Goueffic Yann , Maurel Blandine 
Published: June 2022

Purpose: Radiation exposure for vascular interventionalists is still a concern. The aim of this study was to assess the value of advanced imaging guidance on radiation exposure and iodinated contrast volume during endovascular treatment of lower extremity arterial disease (LEAD). Materials and Methods: It was a prospective, randomized, monocentric, pilot, single-operator study, conducted from June 2018 to October 2019. Consecutive patients requiring a preoperative computed tomography angiography (CTA) for a symptomatic LEAD and scheduled for an iliac and/or femoropopliteal endovascular repair in a hybrid room were included. Patients were randomly assigned to the use of fusion imaging guidance (Vessel Navigator®, Philips) or not. The primary endpoint was the dose area product (DAP, Gy.cm²). Secondary endpoints were DAP for fluoroscopy, DAP for fluorography, Air Kerma, fluoroscopy time, volume of contrast, and number of digital subtraction angiography (DSA). Data were expressed in median [Q1-Q3]. Results: In all, 64 of the 77 patients enrolled (34 in fusion group, 30 in control group, 82% men, 65.8 years [61–71]) were included. Groups were similar in terms of comorbidities, BMI (26 kg/cm2 [24–28]), but lesion location were not equally distributed (p=0.004). There was no significant difference between the groups regarding DAP (31.6 Gy.cm2 [23.4; 46.9] for fusion group vs 25.6[16.9; 34.0] Gy.cm2; p=0.07), Air Kerma (160 mGy [96;3365] vs 115 mGy [76;201]; p=0.12, fluoroscopy time (560 seconds [326;960] vs 454 seconds [228;1022]; p=0.44), contrast volume (60 ml [42;80] vs 50 ml [40;66]; p=0.10), or operative time (68 minutes [55;90] vs 46 minutes [30;80]; p=0.06). The median number of DSA was 14 [10–18] in the fusion group versus 11 [6–18]; p=0.049. Conclusion: Fusion imaging guidance does not affect radiation exposure and contrast volume during endovascular revascularisation of iliac and femoropopliteal occlusive disease in a hybrid room environment.
A modified method of elastase-induced saccular aneurysm creation in rabbits: Schematic representation of the method
Authors: Won Dong-Sung , Kim Mi Hyeon , Lee Ki Baek , Yoon Jong Tae , Park Yubeen , Lee Deok Hee 
Published: June 2022

Background The purpose of our study was to investigate the safety and effectiveness of a modified technique using a short guiding catheter for instillation of elastase in comparison with the previously described method of creating elastase-induced aneurysm in rabbits. Methods Following right common carotid artery (RCCA) access using an arterial sheath and inflating the Fogarty balloon in the subclavian artery, a short guiding catheter was used for the instillation of the elastase in the experimental group (n = 5) while it was performed with a microcatheter in the control group (n = 5). The procedure duration was recorded from the RCCA puncture to the sheath removal. The histological changes were characterized using H&E and Masson's trichrome (MT) staining. Results The procedure time was 23 ± 2 min in the experimental group and 29 ± 2 min in the control group. All the rabbits (100%) in the experimental group survived without neurologic deficits, but two rabbits (40%) survived in the control group. All aneurysms were created in the saccular shape (100%) with a neck size of 2.3 ± 0.29 mm, a width of 2.75 ± 0.36 mm, and height of 6.37 ± 0.46 mm, and a dome to neck ratio of 1.21 ± 0.23. The aneurysm walls were partly thickened due to the degradation of the media tunica and adventitia proliferation with loss of the internal elastic lamina. Conclusion By using a short guiding catheter, we could instill the elastase in a more effective and safe manner in the creation of the elastase-induced aneurysm model in rabbits.
Association of Early and Late Hospital Readmissions with a Novel Housing-Based Socioeconomic Measure
Authors: Zurek Kaitlyn I. , Boswell Christopher L. , E. Miller Nathanial , L. Pecina Jennifer , D. Decker Matthew , I. Wi Chung , Garrison Gregory M. 
Published: June 2022

Background While socioeconomic status has been linked to hospital readmissions for several conditions, reliable measures of individual socioeconomic status are often not available. HOUSES, a new measure of individual socioeconomic status based upon objective public data about one's housing unit, is inversely associated with overall hospitalization rate but it has not been studied with respect to readmissions. Purpose To determine if patients in the lowest HOUSES quartile are more likely to be readmitted within 30 days (short-term) and 180 days (long-term). Methods A retrospective cohort study of 11 993 patients having 21 633 admissions was conducted using generalized linear mixed-effects models. Results HOUSES quartile did not show any significant association with early readmission. However, when compared to the lowest HOUSES quartile, the second quartile (OR = 0.90, 95%CI 0.83-0.98) and the third quartile (OR = 0.91, 95%CI 0.83-0.99) were associated with lower odds of late readmission while the highest quartile (OR = 0.91, 95%CI 0.82-1.01) was not statistically different. Conclusion HOUSES was associated with late readmission, but not early readmission. This may be because early readmissions are influenced by medical conditions and hospital care while late readmissions are influenced by ambulatory care and home-based factors. Since HOUSES relies on public county assessor data, it is generally available and may be used to focus interventions on those at highest risk for late readmission.
Anchoring IgG-degrading enzymes to the surface of platelets selectively neutralizes antiplatelet antibodies
Authors: Lynch Donald R. , Stringham Emily N. , Zhang Boya , Balbin-Cuesta Ginette , Curtis Brian R. , Palumbo Joseph S. , Greineder Colin F. , Tourdot Benjamin E. 
Published: June 2022

AbstractImmune thrombocytopenia (ITP) is an acquired bleeding disorder characterized by immunoglobulin G (IgG)–mediated platelet destruction. Current therapies primarily focus on reducing antiplatelet antibodies using immunosuppression or increasing platelet production with thrombopoietin mimetics. However, there are no universally safe and effective treatments for patients presenting with severe life-threatening bleeding. The IgG-degrading enzyme of Streptococcus pyogenes (IdeS), a protease with strict specificity for IgG, prevents IgG-driven immune disorders in murine models, including ITP. In clinical trials, IdeS prevented IgG-mediated kidney transplant rejection; however, the concentration of IdeS used to remove pathogenic antibodies causes profound hypogammaglobulinemia, and IdeS is immunogenic, which limits its use. Therefore, this study sought to determine whether targeting IdeS to FcγRIIA, a low-affinity IgG receptor on the surface of platelets, neutrophils, and monocytes, would be a viable strategy to decrease the pathogenesis of antiplatelet IgG and reduce treatment-related complications of nontargeted IdeS. We generated a recombinant protein conjugate by site-specifically linking the C-terminus of a single-chain variable fragment from an FcγRIIA antibody, clone IV.3, to the N-terminus of IdeS (scIV.3-IdeS). Platelets treated with scIV.3-IdeS had reduced binding of antiplatelet IgG from patients with ITP and decreased platelet phagocytosis in vitro, with no decrease in normal IgG. Treatment of mice expressing human FcγRIIA with scIV.3-IdeS reduced thrombocytopenia in a model of ITP and significantly improved the half-life of transfused platelets expressing human FcγRIIA. Together, these data suggest that scIV.3-IdeS can selectively remove pathogenic antiplatelet IgG and may be a potential treatment for patients with ITP and severe bleeding.
Improvements in allogeneic hematopoietic cell transplantation outcomes for adults with ALL over the past 3 decades
Authors: Nishiwaki Satoshi , Akahoshi Yu , Morita-Fujita Mari , Shimizu Hiroaki , Uchida Naoyuki , Ozawa Yukiyasu , Fukuda Takahiro , Tanaka Masatsugu , Ikegame Kazuhiro , Ota Shuichi , Katayama Yuta , Takahashi Satoshi , Kawakita Toshiro , Ara Takahide , Onizuka Makoto , Kimura Takafumi , Tanaka Junji , Atsuta Yoshiko , Arai Yasuyuki 
Published: June 2022

AbstractAllogeneic hematopoietic cell transplantation (allo-HCT) is a promising treatment for adult acute lymphoblastic leukemia (ALL), an intractable hematological malignancy. The trends in allo-HCT outcomes over the past 30 years were examined to verify the efficacy of evolving treatment methods and to identify further challenges. We analyzed data from a registry database that included 8467 adult ALL patients who underwent their first allo-HCT between 1990 and 2019. The period was divided into three 10-year intervals for analysis. Five-year overall survival improved from 48.2% to 70.2% in the first complete remission (CR1), from 25.6% to 44.1% in subsequent CR, and from 10.0% to 22.7% in non-CR. Nonrelapse mortality improved over the 3 decades in each disease stage. However, the relapse rate only improved in CR1 every decade (26.3% to 15.9% in CR1, 33.4% to 32.8% in subsequent CR, and 53.6% to 54.8% in non-CR). Although there were continual improvements in adjusted survival for Philadelphia chromosome (Ph)-positive patients, the improvement was inadequate for Ph− patients with t(4;11), t(8;14), t(14;18), or hypodiploidy. Allo-HCT outcomes for adults with ALL have improved over the past 30 years. Improved outcomes in the future will require more effective prevention of relapse in patients with ALL not in CR1 and in those with high-risk chromosomal abnormalities.
Demographic and clinical characteristics of patients with α1-antitrypsin deficiency genotypes PI*ZZ and PI*SZ in the Spanish registry of EARCO
Authors: Torres-Durán María , López-Campos José Luis , Rodríguez-Hermosa Juan Luis , Esquinas Cristina , Martínez-González Cristina , Hernández-Pérez José María , Rodríguez Carlota , Bustamante Ana , Casas-Maldonado Francisco , Barrecheguren Miriam , González Cruz , Miravitlles Marc 
Published: June 2022

BackgroundThe Spanish registry of α1-antitrypsin deficiency (AATD) integrated in the European Alpha-1 Research Collaboration (EARCO) provides information about the characteristics of patients, in particular those with the PI*SZ genotype, which is frequent in Spain.MethodIndividuals with severe AATD defined as proteinase inhibitor (PI) genotypes PI*ZZ, PI*SZ and other rare deficient variants were included from February 1, 2020, to February 1, 2022. The analysis focused on a comparison of the characteristics of PI*ZZ and PI*SZ patients.Results409 patients were included (53.8% men) with a mean±sdage of 53.5±15.9 years. Genotypes were PI*ZZ in 181 (44.7%), PI*SZ in 163 (40.2%), PI*SS in 29 (7.2%) and other in 32 (7.9%). 271 (67.4%) had lung disease: 175 chronic obstructive pulmonary disease (43.5%), 163 emphysema (40.5%) and 83 bronchiectasis (20.6%). Patients with the PI*SZ genotype were younger, more frequently non-index cases and had a lower frequency of respiratory diseases except asthma compared with PI*ZZ patients. Among patients with respiratory diseases, PI*SZ individuals were significantly older both at onset of symptoms and at diagnosis; only asthma was more frequent in PI*SZ than in PI*ZZ individuals. Twelve PI*SZ patients (15.4%) received augmentation therapy compared with 94 PI*ZZ patients (66.2%; p<0.001).ConclusionsThere is a high prevalence of PI*SZ in Spain. Patients with the PI*SZ genotype were older at symptom onset and diagnosis and had less severe lung disease compared with PI*ZZ patients. The prevalence of asthma was higher in PI*SZ, and up to 15% of PI*SZ patients received augmentation therapy.
Control of Magnetic Particle Size in Ferrofluid and Its Effect on Rheological Properties
Authors: Chen Siyu , Li Decai 
Published: June 2022

AbstractRheological properties are the theoretical basis and the key to common problems in ferrofluid applications, therefore they are expected to be adjustable to satisfy different technical requirements through altering the microstructure of ferrofluid during the process of preparation. In this paper, Four ferrofluid samples with different magnetic particle size were prepared by controlling the concentration of precursor solution during co-precipitation process and the rheological properties of these samples were investigated. These samples exhibited field-controlled rheological properties. Eternal magnetic field would enhance the formation of microstructures, resulting in an increase of viscosity. While with the increase of shear rate, microstructures tended to be destroyed, causing viscosity to decrease. There were two opposing mechanisms of the influence of precursor solution concentration. On one hand, the reduction of the precursor solution concentration would produce primary magnetic particles of smaller size. But on the other hand, the surfactant became insufficient to completely coat the magnetic particles because of an increased specific surface area, causing the magnetic particles to aggregate and form secondary clustering structures which strongly enhanced the magnetoviscous effect and weakened the viscoelastic effect.
A Shakedown Strength Based Parametric Optimization Technique and Its Application on an Airtight Module
Authors: Huang Songhua , Xu Yugong , Zhang Lele , Chen Geng , Liu Feng 
Published: June 2022

AbstractIn aerospace engineering, design and optimization of mechanical structures are usually performed with respect to elastic limit. Besides causing insufficient use of the material, such design concept fails to meet the ever growing needs of the light weight design. To remedy this problem, in the present study, a shakedown theory based numerical approach for performing parametric optimization is presented. Within this approach, strength of the structure is measured by its shakedown limit calculated from the direct method. The numerical method developed for the structural optimization consists of nested loops: the inner loop adopts the interior point method to solve shakedown problems pertained to fixed design parameters, while the outer loop employs the genetic algorithm to find optimal design parameters leading to the greatest shakedown limit. The method established is first verified by the classic plate-with-a-circular-hole example, and after that it is applied to an airtight module for determining few key design parameters. By carefully analyzing results generated during the optimization process, it is convinced that the approach can become a viable means for designing similar aerospace structures.
Ophthalmic manifestation after SARS-CoV-2 vaccination: a case series
Authors: Murgova Snezhana , Balchev Georgi 
Published: June 2022

Abstract
Background
The aim of this report is to describe ocular side effects in patients who received one of the two COVID-19 vaccines – Astra Zeneca or Pfizer-Biontech and to contribute to the common understanding of the COVID-19 vaccination process.

Results
Three patients reactivated underlying herpetic disease and developed uveitis and keratitis. Two of them were vaccinated with Pfizer and one was with Astra Zeneca. Two patients were vaccinated with Pfizer-Biontech and had thrombosis on the 8th and 10th days following the day of vaccination. The man has diagnosed with nonarteritic anterior ischemic optic neuropathy and the woman had a subarachnoid haemorrhage, ptosis of upper eyelid and deviated eyeball.

Conclusion
There is a causal relationship between vaccines and the underlying disease. For more details, further large studies are necessary.