bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Neurobiological Markers in Phenotype-stratified Rats
Modeling High or Low Vulnerability to Compulsive Behavior: A Narrative
Review
Authors: Martín-González Elena , Olmedo-Córdoba Manuela , Flores Pilar , Moreno-Montoya Margarita 
Published: November 2022

Abstracts:
Compulsivity is a key manifestation of inhibitory control deficit and a cardinal symptom in
different neuropsychopathological disorders such as obsessive-compulsive disorder, schizophrenia,
addiction, and attention-deficit hyperactivity disorder. Schedule-induced polydipsia (SIP), is an animal
model to study compulsivity. In this procedure, rodents develop excessive and persistent drinking behavior
under different food-reinforcement schedules, that are not related to homeostatic or regulatory
requirements. However, there are important individual differences that support the role of high-drinker
HD rats as a compulsive phenotype, characterized in different paradigms by inhibitory response deficit,
cognitive inflexibility, and resistant to extinction behavior; with significant differences in response
to pharmacological challenges, and relevant neurobiological alterations in comparison with the control
group, the non-compulsive low drinker LD group on SIP. The purpose of this review is to collate and
update the main findings on the neurobiological bases of compulsivity using the SIP model. Specifically,
we reviewed preclinical studies on SIP, that have assessed the effects of serotonergic, dopaminergic,
and glutamatergic drugs; leading to the description of the neurobiological markers, such as the
key role of the serotonin 5-HT2A receptor and glutamatergic signaling in a phenotype vulnerable to
compulsivity as high drinker HD rats selected by SIP. The review of the main findings of HD rats on
SIP helps in the characterization of the preclinical compulsive phenotype, disentangles the underlying
neurobiological, and points toward genetic hallmarks concerning the vulnerability to compulsivity.
Non-alcoholic Fatty Liver Disease in Children
Authors: Muzurović Emir , Polyzos Stergios A. , Mikhailidis Dimitri P. , Borozan Sanja , Novosel Dušanka , Cmiljanić Oleg , Kadić Nataša , Mantzoros Christos S. 
Published: November 2022

Abstract:
Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease in the
paediatric age. The growing prevalence of NAFLD and its advanced phenotype, non-alcoholic steatohepatitis
(NASH), in children and adolescents parallels similar trends in obesity and type 2 diabetes
mellitus. This trend may have serious long-term implications, including hepatic and extra-hepatic morbidity
and mortality, the latter being related mostly due to cardiovascular disease and malignancies. This
narrative review, which included 236 articles, summarizes current evidence on paediatric NAFLD, including
pathophysiology, risk factors, complications, prevention and treatment (existing and emerging).
Early recognition of NAFLD followed by timely and adequate management seems to be important on an
individual basis. A global “call to action” regarding paediatric NAFLD seems appropriate to mitigate
the burden of this disease.
Imidazole and Derivatives Drugs Synthesis: A Review
Authors: Rani Nidhi , Singh Randhir , Kumar Praveen 
Published: November 2022

Abstract:
Imidazoles have long held a special place in heterocyclic chemistry, and their derivatives
have piqued interest in recent years due to their diverse chemistry and pharmacology features.
Imidazole is a biologically and pharmaceutically important nitrogen-containing heterocyclic
ring. As a result, researchers have been interested in imidazole molecules. For a century and
a half, purine, histamine, and other natural compounds all contained the imidazole ring. A number
of imidazole drugs have been prepared and marketed for the treatment of various diseases. In
view of this, we herein report a detailed account of synthetic procedures for various imidazole
drugs.
DHOSGR: lncRNA-disease Association Prediction Based on Decay
High-order Similarity and Graph-regularized Matrix Completion
Authors: Lin Zhiyi , Xie Guobo , Jiang Zelin , Gu Guosheng , Sun Yuping , Su Qing , Cui Ji , Zhang Huizhe 
Published: November 2022

Background:
It has been shown in numerous recent studies that long non-coding RNAs (lncRNAs) play a vital role in the regulation of various biological processes, as well as serve as a basis for understanding the causes of human illnesses. Thus, many researchers have developed matrix completion approaches to infer lncRNA–disease connections and enhance prediction performance by using similarity information.

Objective:
Most matrix completion approaches are solely based on the first-order or second-order similarity between nodes, and higher-order similarity is rarely considered. In view of this, we developed a computational method to incorporate higher-order similarity information into the similarity network with different weights using a decay function designed by a random walk with restart (DHOSGR).

Methods:
First, considering that the information will decay as the distance increases during network propagation, we defined a novel decay high-order similarity by combining the similarity matrix and its high-order similarity information through a decay function to construct a similarity network. Then, we applied the similarity network to the objective function as a graph regularization term. Finally, a proximal splitting algorithm was used to perform matrix completion to infer relationships between diseases and lncRNAs.

Results:
In the experiment, DHOSGR achieves a superior performance in leave-one-out cross validation (LOOCV) and 100 times 5-fold cross validation (5-fold-CV), with AUC values of 0.9459 and 0.9334±0.0016, respectively, which are better than other five previous models. Moreover, case studies of three diseases (leukemia, lymphoma, and squamous cell carcinoma) demonstrated that DHOSGR can reliably predict associated lncRNAs.

Conclusion:
DHOSGR can serve as a high efficiency calculation model for predicting lncRNA-disease associations.
Biotechnological Approaches to Increase the Bacterial and Fungal Disease Resistance in Potato
Authors: Kvasko Olena , Kolomiiets Yuliia , Buziashvili Anastasiia , Yemets Alla 
Published: November 2022

Potato (Solanum tuberosum) is a valuable cultivated vegetable with high nutritional qualities containing a variety of essential ingredients such as starch, vitamins and essential minerals. However cultivating potatoes is significantly complicated by diseases caused by a number of phytopathogens of both bacterial and fungal nature. Phytophthora infestans, Alternaria sp., Phoma exigua, Rhizoctonia solani, Fusarium sp., Verticillium sp., Clavibacter michiganensis subsp. sepedonicus, Pectobacterium sp., Dickeya sp. are considered amongst the most dangerous phytopathogens.
This paper reviews the latest biotechnological approaches to the creation of potato plants resistant to a wide range of pathogens. In particular, the possibilities of applying genetic engineering methods to obtain potato plants resistant to pathogens, such as Solanum venture, S. mochiquence, S. demissum, S. bulbocastanum; avirulence genes; genes of antimicrobial peptides of plant, bacterial and animal origin by transferring the genes of resistance (R-genes) isolated from systematically related species into their genome. The review states that marker-assisted selection is suitable for obtaining varieties of S. tuberosum resistant to bacterial and fungal phytopathogens, where the R-genes or QTL regions can act as markers. Prospects for the use of genome editing technology using CRISPR/Cas9 or TALEN systems as one of the newest approaches to creating phytopathogen-resistant S. tuberosum plants have been considered. Achievements and successes in this way using these methods are analyzed in a detailed way in this review.
The Relationship between Social Support and Hopelessness among Iranian Students during Coronavirus disease 2019 (COVID-19) Pandemic
Authors: Hajinasab Negar , Amiri Mehrnegar , Sharifi Mahnaz , Sanati Tayebe , Dolatabadi Zari , Amiri-Farahani Leila 
Published: November 2022

Background:
The coronavirus disease 2019 (COVID-19) pandemic has major consequences for public health worldwide, especially for mental health. Hope is a dynamic motivational system that empowers one to achieve goals. Social support similarly increases the feeling of well-being to cope with hopelessness. The present study was conducted to determine the relationship between social support and hopelessness in students studying at the Iran University of Medical Sciences during the COVID-19 pandemic considering the importance of performance in medical sciences students.

Methods:
This cross-sectional study was performed continuously for five months, from January to May 2021, at the Iran University of Medical Sciences, Tehran, Iran, where the Persian language is predominantly spoken. Participants were included if they could consent to participate in the study and internet access and membership in social networks. Those who did not fully engage with our data collection tools were excluded. A demographic information form, the Beck Hopelessness Scale (BHS), and the Multidimensional Scale of Perceived Social Support (MPSS) were provided to students via social networks. After students (n=300) completed the questionnaires, data were analyzed through SPSS software version 21.

Results:
The mean age of participants was 23.46 (18-51) years. The mean score of hopelessness among the participants was 6.2. The majority of students (35%) had mild hopelessness, 34.7% had a minimum level of hopelessness, 26.7% had a moderate level of hopelessness, and 11% had a high level of hopelessness. The mean social support score was 59.49, with 52.3% of students having a high level of social support. The correlation coefficient between social support and hopelessness was - 0.401 (p < 0.001). Field of study, degree level, marital status and lifestyle were significantly correlated with hopelessness. Also, only marital status had a significant relationship with social support among students. The results of multiple linear regression analysis showed that out of the variables included in the model, only the variable of social support had a significant effect on the hopelessness score, so this variable predicted 18% of the hopelessness score.

Conclusion:

Given the inverse relationship between social support and hopelessness, it is suggested to increase the level of social support for students to improve their sense of hopelessness.
Agro-waste Mediated Biosynthesis of Zinc Oxide Nanoparticles and their
Antibacterial Properties: Waste to Treat
Authors: Singh Darshan , Singh Laxman , Rawat Deepti , Kumar Amar , Rawat Preeti , Singhal Rahul 
Published: November 2022

Background:
Biogenic fabrication of metal oxide nanoparticles has been gaining interest
over conventional methods. Biological methods make use of plant materials and microbial agents as
reducing as well as capping agents. The present work reports the biosynthesis of ZnO NPs from agricultural
wastes produced in every household.

Objective:
A significant portion of municipal solid organic waste (MSOW) consists of agricultural
waste. Utilization of this agricultural waste towards cleaning water of pathogens through the synthesis
of nanoparticles has far-reaching implications, such as curbing soil pollution and water pollution.

Method:
Preliminary confirmation was done by the visual formation of a pale yellow/dirty white precipitate
of ZnO NPs. These were further characterized by different spectroscopic techniques, such as
FT-IR, SEM, EDAX, and HRTEM.

Results:
The HRTEM study revealed that NPs obtained had sizes between 30-52 nm. Fabricated ZnO
NPs were analyzed for their antibacterial activity by disk diffusion method, and they exhibited striking
antibacterial activity against E. coli and bacillus subtilis.

Conclusion:
Exploring the potential of waste and its conversion into a value-added product is a novel
step. ZnO nanoparticles were successfully synthesized from agricultural wastes through an environmentally
friendly synthetic route, and the synthesized ZnO NPs were found to be potent in inhibiting
the growth of bacteria.
Enrollment and Completion Characteristics for Novel Remote Delivery Modes of the Self-management Programs During the COVID-19 Pandemic: Exploratory Analysis
Authors: Pullyblank Kristin , Atav Serdar 
Published: November 2022

Background
In-person, evidence-based, peer-facilitated chronic disease self-management programs have been shown to be effective for individuals from a variety of backgrounds, including rural and minority populations and those with lower socioeconomic status. Based in social learning theory, these programs use group processes to help participants better manage their chronic disease symptoms and improve their quality of life. During the pandemic, these in-person programs were forced to rapidly transition to remote delivery platforms, and it was unclear whether doing so increased disparities within our rural population.

Objective
The objectives of this analysis were to ascertain self-management program enrollment and completion characteristics between 2 remote delivery platforms, as well as determine the individual level characteristics that drove enrollment and completion across delivery modes.

Methods
We analyzed enrollment and completion characteristics of 183 individuals who either enrolled in a self-management workshop delivered through a web-based videoconference (VC) system or through a traditional, audio-only conference call (CC) offered by our health care network between April and December 2020. Chi-square tests of association were used to describe the characteristics of and differences between groups. Logistic regression analysis was used to determine significant predictors of enrollment and completion.

Results
Those who enrolled in the VC platform were significantly likelier to be younger and college educated than those who enrolled in the CC platform. Those who completed a program, regardless of delivery mode, were likelier to be older and college educated than those who did not complete a program. Multivariate analyses indicated that of those enrolled in the CC platform, completers were likelier to not be enrolled in Medicaid. Among those enrolled in the VC platform, completers were older, college graduates, female, and likelier to have reported poorer health than those who did not complete the program.

Conclusions
The transition of self-management programs to remote delivery modes, particularly to those that rely on VC platforms, revealed that certain demographic groups may no longer be able or willing to access the service. Efforts need to be made to increase engagement in remote self-management workshops. In addition, equivalent quality services that do not rely on a digital platform must continue to be offered in order to promote health equity.
Edukasi Hukum tentang Legalitas Vaksinasi Virus Covid–19 bagi Masyarakat Desa Bungin Tinggi-Sumatera Selatan
Authors: Muhammad Syahri Ramadhan Syahri , Warsito Happy , Nugraha Adrian , Arifin M Zainul 
Published: November 2022

Masyarakat masih bersepsi bahwa vaksinasi virus covid – 19 mempunyai efek negative bagi kesehatan penggunanya. Masyarakat awam dapat menumbuhkan rasa kepercayaan terhadap program vaksin tersebut dengan melihat landasan yuridis dengan adanya vaksin tersebut. Legalitas atas program vaksin ini sudah cukup memberikan keyakinan terhadap masyarakat mengenai keamanan hingga khasiat dari penggunaan vaksin covid–19 tersebut. Metode pelaksanaan yang digunakan ialah metode ceramah disertai sesi tanya jawab dan kuisioner. Tanggapan masyarakat desa bungin tinggi sekaligus peserta dalam penyuluhan sangat baik. Masyarakat mengetahui dasar hukum yang mengatur produk vaksin virus covid–19, secara tidak langsung menjelaskan bahwa vaksin tersebut higienis dan aman untuk digunakan masyarakat. Hal ini dikarenakan proses pembentukan regulasi terkait keberadaan vaksin virus covid–19, tidak hanya melalui prosedur tata rancangan pembentukan peratudan perundang–undangan saja, tetapi juga melalui uji klinis atas produk vaksin yang diatur tersebut. Melalui pengabdian ini, diketahui terjadi peningkatan pemahaman mengenai asas legalitas dan hubungannya dengan penetapan berbagai produk jenis vaksin serta upaya Perlindungan hukum bagi masyarakat terkait dengan proses vaksinasi covid – 19 yang dicanangkan pemerintah.

Legal Education on the Legality of Covid-19 Virus Vaccination for the Village Community of Bungin Tinggi-South Sumatra
People still perceive that the COVID-19 virus vaccination harms the health of its users. The general public can develop a sense of trust in the vaccine program by looking at the juridical basis of the vaccine. The legality of this vaccine program is enough to give confidence to the public regarding the safety and efficacy of using the COVID-19 vaccine. The implementation method used is the lecture method accompanied by a question-and-answer session and a questionnaire. The response from the Bungin village community as well as participants in the counseling was very good. The public knows the legal basis that regulates the covid-19 virus vaccine product, indirectly explaining that the vaccine is hygienic and safe for public use. This is due to the process of establishing regulations regarding the presence of a covid-19 virus vaccine, not only through the procedure for the design of the formation of laws and regulations but also through clinical trials of the regulated vaccine products. Through this service, it is known that there is an increase in understanding of the principle of legality and its relationship with the determination of various types of vaccine products as well as legal protection efforts for the community related to the COVID-19 vaccination process launched by the government.
Timeline tool for analyzing the relationship between students-teachers-artifacts interactions and meaning-making
Authors: Bagossi Sara , Swidan Osama , Arzarello Ferdinando 
Published: November 2022

Meaning-making in teaching-learning mathematical processes is a relevant issue analysed through different philosophical and educational frames. In particular, the use of digital tools in mathematics education affects the meaning-making processes. This paper discusses meaning-making from a

phenomenological standpoint, in which interpretative activities are relevant. This approach requires a careful analysis of the semiotic resources’ evolution, including those related to the used digital tools. The paper aims to introduce an analytical tool, the Timeline. This tool is an elaboration on previous analysis tools, like the interaction flowchart and the semiotic bundle. Such a tool allows the analysis of relationship among interactions, semiotic resources, and meaning-making. In this paper, the Timeline is used to analyze two episodes from two different learning experiments where GeoGebra and augmented reality are used. High school students from Italy and Israel participated in this study. Video recording has been used to document the entire learning experiments. The analysis provides evidence that the Timeline enables investigating the relationship between students-teacher-artifacts interactions and meaning-making. Moreover, results may give teachers ideas for using digital tools to foster students’ meaning-making.
Perceived Obstacles to Conducting and Publishing Practice-Relevant Academic Accounting Research
Authors: Daugherty Brian E. , Dickins Denise , Pitman Marshall K. , Tervo Wayne A. 
Published: November 2022

ABSTRACT
If academic accounting research is not of interest to practicing accountants and regulators, public interest wanes, the academy becomes an echo chamber of its own ideas, and researchers risk relevancy and financial support. To provide insight about the obstacles perceived to reduce the likelihood that accounting academics will publish practice-relevant research in academic journals, we sent a survey to more than 5,600 U.S. accounting faculty members. Based on 567 survey responses, we identify eight obstacles that the survey respondents believe reduce the likelihood that they will publish practice-relevant research. The most frequently reported obstacle is that academic journal editors are not interested in publishing practice-related research (77 percent of survey respondents). We also provide evidence that the more academics interact with practitioners, the more likely they are to conduct and publish practice-relevant academic research. Recommendations and observations are included to help address the identified obstacles.
Internal Auditors’ Perceptions of Information Technology-Related Risks: A Comparison Between General Auditors and Information Technology Auditors
Authors: Nuijten Arno L. P. , Keil Mark , Zwiers Bert 
Published: November 2022

ABSTRACT
With the growing role of information technology (IT), many organizations have incorporated IT governance practices that include keeping executives apprised of IT risks. To perform this function, organizations rely upon their internal audit staff to obtain an independent evaluation of IT risks. Although both general and IT auditors are involved in assessing IT risks, they may not be equally adept at identifying such risks. We draw on the expert versus nonexpert perspective to understand how general and IT auditors perceive IT risks differently. Through a quasi experiment with 70 internal auditors of a financial institution, we found that general auditors perceived IT risks to be lower than their IT audit colleagues. We also found that personal IT risk preferences influenced the level of IT risks that general auditors perceived. Personal IT risk preferences did not affect the risk perceptions of IT auditors. Implications for both research and practice are discussed.
Understanding the Ecosystem of Enterprise Risk Governance
Authors: Beasley Mark S. , Branson Bruce C. , Braumann Evelyn C. , Pagach Donald P. 
Published: November 2022

ABSTRACTApproaches to risk governance are not homogeneous across organizations. Some organizations invest heavily in building formal and strategically focused enterprise-wide risk governance processes whereas others exhibit reduced formality and focus, allowing risk governance to be less structured. We argue that risk governance may best be described as a service dependent upon a network (or ecosystem) of participants who include users of risk information and providers who design and implement risk governance processes. Using a survey sample of 2,380 observations from 2011 to 2016, we find that external calls for enhanced risk governance are positively associated with risk governance processes having greater formality and strategic focus. We find this relationship is partially mediated by internal demands for enhanced risk governance. Further, we find that the positive association between internal demands and enhanced risk governance is reduced by resource constraints and that a risk-seeking attitude is negatively associated with enhanced risk governance.Data Availability: Contact the authors.JEL Classifications: G30; M10; M14; M40.