bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment of Patient-derived Xenografts of Retinoblastoma &amp; Choroidal Melanoma on the Avian Chorioallantoic Membrane
Authors: Kant Nimita , Jayaraj Perumal , Sen Seema , Rupani Harshita , Kumar Pranavi , Dahiya Shefali , Chugh Palak , Gupta Muskaan , Sengar Manisha 
Published: June 2022

Abstract
Background: To develop a viable in vivo chorioallantoic membrane (CAM) model to study the growth and invasion of patient-derived Retinoblastoma (RB) and Choroidal Melanoma (CM) xenografts (PDXs). The study utilizes primary tumor samples instead of cancer cell lines which provides a more authentic representation of tumors due to conserved morphology and heterogeneity. Methods: Fertilized chicken eggs were procured, windowed, and their CAM layers were dropped. On embryonic development day (EDD) 10, freshly cut patient-derived CM and RB tumors were implanted on the CAM layer and the set-up was incubated for 7 days. The tumor-embedded CAM layer was harvested on EDD-17 and the extracted tumor samples were subjected to Hematoxylin and Eosin staining and Immunohistochemical analysis to evaluate the extent of tumor invasion. Results: Significant changes in the vascularity around the RB and CM PDXs were observed indicating an angiogenic environment. The cross-sectional histological view of the tumor implant site revealed the invasion of both the tumor types into CAM. Invasion of CM to CAM mesoderm was visualized in the form of pigmented nodules and of RB was indicated by synaptophysin and Ki-67 positivity in IHC.Conclusion: The CAM xenograft model was successfully able to support the growth of CM and RB PDXs and their invasion in CAM, thus presenting as a feasible alternative to mammalian models for studying tumorigenicity and invasiveness of ocular tumors. Moreover, this model can further be utilized to develop personalized medicine by inoculating patient-specific tumors for pre-clinical drug screening.
Strength enhancement of LiZnVO 4 nanoparticles incorporated with PVDF nanocomposites for high-performance lithium-ion battery application
Authors: Elashmawi I. S. , Ismail A. M. , Abdelghany A. M. , Yassin A. Y. 
Published: June 2022

Abstract
This work aims to prepare LiZnVO4 nanoparticles and incorporate them into PVDF as a host polymeric material using the casting method for rechargeable Li-battery applications. The effect of LiZnVO4 on the structural and optical properties of the samples was studied using XRD, FT-IR, and UV-is techniques. Moreover, the electrical conductivity of the prepared films was studied. The XRD spectra show semicrystalline structure of PVDF and the rhombohedral structure of LiZnVO4. Scherer's equation was used to determine the crystallite size of LiZnVO4 which is nearly 83 nm. The interaction between PVDF and LiZnVO4 was approved by shifting some FT-IR bands. The band gap energies were decreased by increasing LiZnVO4 due to the density in the localized states in the mobility band gap in PVDF. The AC parameters as a function of frequency and temperature were investigated in detail. Both ε' and ε" had their maximum values at low frequencies and decreased as the frequency and temperature increased. The dielectric properties and tan δ were improved, particularly 5 wt% of LiZnVO4, which confirms the XRD and FT-IR results indicating their suitability as a suitable base material for designing and developing promising energy storage devices and lithium batteries.
Multiphysics analysis for fluid-structure interaction of flexible baffle inside wavy cavity with slipping wall
Authors: Al-Jibory Mohammed Wahhab , Rahman Mokdad Hayawi 
Published: June 2022

Abstract
The development of methods for making fluids in a state of turbulence to obtain better heat transfer and its strong effect on the elastic wall. One of the ways that we can obtain the turbulent state of the fluid is to make one of the surfaces of the solid slide at a certain speed. This slip leads to the surface tension in a state of turbulence, and this rotates the fluid flow in a way large and in order to obtain better turbulence, it is used to make the surfaces surrounding the fluid in a directional way to help rotate the fluid. The results proved the effectiveness of this stereotype, as the force of the effect of the fluid velocity on the elastic wall was in the case of the thickness of 0.5 mm and the sliding velocity of 0.9 m/s, where the deformation was 5.6 mm, which is the best strike condition was deduced either at 2 mm thickness and 0.1 m/s sliding velocity where the deformation was 0.272 mm which is the least deformation reached by the wall.
Google Cloud Platform (GCP) ecosystem for life- saving mission for millions on Covid-19 vaccination
Authors: Valavandan Ramamurthy , Reddy Kumaraswamy , Parayatham Prasanth , Sherif Ubaiyadulla , Kohli Pallav , Sharma Vikram , S Pragathi , R Vijay , Mukherjee Surasa , Ambekar Nitin , Sai Dinesh , Baran Santosh , Singh Vijender , Uniyal Saurabh , B Praveen , Ahmed Musheer 
Published: June 2022

Abstract
Google Cloud Platform (GCP) ecosystem helps in the vaccination drive for World Health Organization (WHO) for stakeholders. The Covid-19 vaccination dataset is available in the WHO portal and refreshed every day. In this paper, the pain area of collecting the source of data and the region or location of the data collection is addressed. A python program is developed to connect to the WHO portal with the help of GCP Scheduler, and process comma-separated variable (CSV) data on daily basis. The parameter of the location of data ingestion is parsed by GCP Big Query by the data analytics and Log Analytics for capturing the location of the data ingestion. An ecosystem developed in GCP Big Query for data analytics and Google Data Studio for data visualization is key for decision-makers of vaccination drive. In the process of access to the WHO dataset available in the WHO, the portal helps the researchers and stakeholders and vision the data visualization in the design and development. Also helps the researchers to give insight into the vaccination data and add value to the beneficiary.
Fatherhood and High-Risk Pregnancy: A Scoping Review
Authors: Jackson Kyle , Erasmus Erika , Mabanga Ntobizodwa 
Published: June 2022

Abstract
Background
The experience of expectant parenthood is commensurate of relative angst and nervousness albeit one of overall excitement and joy. However, when the pregnancy is regarded as high-risk, this experience changes dramatically for both parents. While literature on high-risk pregnancies is gaining traction, the focus is predominantly on the mother’s experiences and therefore, a paucity exists in exploring the father’s experiences of a high-risk pregnancy. This study aimed to determine the current extent of literature focusing on father’s experiences of a high-risk pregnancy using a scoping review methodology.
Method
Nine databases were reviewed using the EBSCOHost metadatabase: Academic Search Complete; APA PsychArticles; CINAHL Plus with full-text; Health Source: Nursing/Academic Edition; MasterFILE Premier; MasterFILE Reference eBook Collection; MEDLINE; SocINDEX with full-text; and eBook Collection. Data was extracted according to the following headings: Authors (including the year of publication); aim of the study; research context; research design; sample characteristics; and key findings.
Results
15 studies were included in this review. A narrative synthesis was applied within which 4 key themes emerged from the data: (1) The father versus the healthcare professional and the hospital environment; (2) The impact of high-risk pregnancies on fathers; (3) Redefining the role of ‘father’ after experiencing high-risk pregnancy and (4) Focus on fathers: Recommendations for support during high-risk pregnancies.
Conclusion
The findings of this study highlights the importance of the inclusion of men and fathers in supporting both his partner and (un)born child. The findings further illustrated the long-lasting impact of trauma felt by men which constrained his ability to support his family. A family-centred approach is needed to further support the family and the impact of a high-risk pregnancy on all members within the family unit.
Association Between Perceived Social Support, Illness Perception, Life Orientation, Life Satisfaction, and Quality of Life Within a Sample of Cancer Patients
Authors: Faraci Palmira , Bottaro Rossella 
Published: June 2022

Introduction: The impact of cancer represents a severe crisis for both patients and relatives. The implications of social support on well-being were well studied but several classifications have been proposed. Objective: The present cross-sectional study was aimed at examining the association between perceived social support (PSS) from family, friends, and significant other and psychological well-being (illness perception, life orientation, life satisfaction, and quality of life). Method: Participants were 138 cancer patients recruited during waiting time for medical treatment or examination, mostly diagnosed for more than six months. The Multidimensional Scale of Perceived Social Support, the Illness Perception Questionnaire, the Life Orientation Test-Revised, the Satisfaction with Life Scale, and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire were administered. Multiple regression analyses were performed. Results: Patients reported fatigue and loss of energy, and environmental pollution and change or bad luck as probable illness causes. Associations between (i) PSS from family and optimism, (ii) PSS from friends and personal control, coherence of disease, optimism, and physical functioning, (iii) PSS from significant other and life satisfaction were found. Conclusions: Our results revealed a specific role for each different PSS source.
Basic Leucine Zipper Protein Nuclear Factor Erythroid 2–related Factor 2
as a Potential Therapeutic Target in Brain Related Disorders
Authors: Goyal Ahsas , Gopika S. , Agrawal Neetu 
Published: June 2022

Abstract:
Nuclear factor erythroid-2-related factor 2 (Nrf2), an inducible transcription factor in
phase II metabolic reactions, as well as xenobiotic response pathway, is referred to as ‘master
regulator’ in anti-oxidant, anti-inflammatory, and xenobiotic detoxification processes. The activity
of Nrf2 is tightly regulated by KEAP1, which promotes ubiquitination, followed by degradation
under homeostatic conditions and also allows Nrf2 to escape ubiquitination, accumulate within the
cell, and translocate in the nucleus upon exposure to the stresses. The Nrf2 pathway has shown an
intrinsic mechanism of defense against oxidative stress (OS). It emerged as a promising therapeutic
target as both inducers and as there is an increasing number of evidence for the protective role of the
Nrf2-ARE pathway towards exacerbations of ROS generation as well as OS, mitochondrial
dysfunction as well as prolonged neuroinflammation is a prevalent pathophysiological process
rooted in brain-related disorders. Elevated concentrations of ROS generation and OS have been
linked to the pathophysiology of a diverse array of brain related disorders, including Alzheimer’s
disease, Parkinson’s disease, Huntington’s disease, Friedrich’s ataxia, multiple sclerosis, and
epilepsy. Further, it not only modulates the articulation of anti-oxidant genes but has often been
associated with implicating anti-inflammatory consequences as well as regulating mitochondrial
functionalities and biogenesis. Therefore, Nrf2 can be considered a potential therapeutic target for
the regimen of various brain-related disorders.
Microwave Induced Green Synthesis: Sustainable Technology for
Efficient Development of Bioactive Pyrimidine Scaffolds
Authors: Sahoo Biswa Mohan , Banik Bimal Krishna , Kumar Bera Venkata Varaha Ravi , Panda Krishna Chandra , Tiwari Abhishek , Tiwari Varsha , Singh Sunil , Kumar Manish 
Published: June 2022

Abstract:
Microwave radiation is used as a heating source during the synthesis of heterocyclic
compounds. The heating mechanisms involved in microwave-induced synthesis include
dipolar polarization and ionic conduction. This heating technology follows the green
protocol as it involves the use of recyclable organic solvents during synthesis. The microwave
heating approach offers a faster rate of reaction, easier work-up procedure, and
higher product yield with purity and also reduces environmental pollution. So, microwave
heating is applied as a sustainable technology for the efficient production of pyrimidine
compounds as one of the heterocyclic moieties. Pyrimidine is a six-membered nitrogenous
heterocyclic compound that plays a significant role due to several therapeutic applications.
This moiety acts as an essential building block for generating drug candidates with diverse
biological activities, including anti-cancer (capecitabine), anti-thyroid (propylthiouracil),
antihistaminic (pemirolast), antimalarial (pyrimethamine), antidiabetic (alloxan), antihypertensive
(minoxidil), anti-inflammatory (octotiamine), antifungal (cyprodinil), antibacterial
(sulfamethazine), etc. This review is focused on the synthesis of pyrimidine analogs
under microwave irradiation technique and the study of their therapeutic potentials.
Nutraceuticals, a Bridge Between Past and Future: Focus on Mushrooms
Biological Activities and Myco-Chemistry
Authors: Patra Jayanta Kumar , Micucci Matteo , Das Gitishree , Budriesi Roberta , Shin Han-Seung , Urso Francesco , Bose Sankhadip , Banerjee Sabyasachi , del Pilar Rodriguez-Torres Maria , Mattioli Laura Beatrice 
Published: June 2022

Background:
Mushrooms are consumed worldwide due to their high nutritional and
nutraceutical values. In addition to the presence of various vitamins, low-fat, and proteins, they are
also an important source of trace elements, dietary fibers, and bioactive compounds. Their potential
therapeutic properties are due to their multiple biological effects, such as antimicrobial, antiviral, antioxidant,
anticancer, immune-modulating, cardioprotective, and antidiabetic properties. The global
market of mushroom farming is anticipated to witness remarkable progress for its potential application
in health products, profitable production and a rising demand for the healthy foods across the globe.
The Asia Pacific marketplace seems to represent the major market of mushrooms, due to the higher
per capita consumption of culinary and medical purposes.

Objective:
Mushrooms have generally low calories, low levels of cholesterol, fats, gluten and sodium.
Several biological effects of mushroom are due to the presence of phenolic components, polysaccharides,
terpenoids, terphenyl-related compounds, and many other lower molecular weight molecules.
This review aims at describing the chemical characterization of several mushrooms species and their
biological effects.

Conclusion:
The current review describes different secondary metabolites found in several mushrooms
and mushrooms extracts, and the molecular mechanisms underlying the biological activities.
Also the antimicrobial activities of mushrooms, mushrooms extracts and isolated compounds from
mushrooms were described.
The description of these activities, related to the presence of specific classes of secondary metabolites
and isolated compounds, may lead to the identification of mycomplexes and mushrooms compounds
that may be further studied for their potential application in nutraceutical products.
LFU-Net: A Lightweight U-Net with Full Skip Connections for Medical
Image Segmentation
Authors: Deng Yunjiao , Wang Hui , Hou Yulei , Liang Shunpan , Zeng Daxing 
Published: June 2022

Background:
In the series of improved versions of U-Net, while the segmentation accuracy continues to improve, the number of parameters does not change, which makes the hardware required for training expensive, thus affecting the speed of training convergence.

Objective:
The objective of this study is to propose a lightweight U-Net to balance the relationship between the parameters and the segmentation accuracy.

Methods:
A lightweight U-Net with full skip connections and deep supervision (LFU-Net) was proposed. The full skip connections include skip connections from shallow encoders, deep decoders, and sub-networks, while the deep supervision learns hierarchical representations from full-resolution feature representations in outputs of sub-networks. The key lightweight design is that the number of output channels is based on 8 rather than 64 or 32. Its pruning scheme was designed to further reduce parameters. The code is available at: https://github.com/dengdy22/U-Nets.

Results:
For the ISBI LiTS 2017 Challenge validation dataset, the LFU-Net with no pruning received a Dice value of 0.9699, which achieved equal or better performance with a mere about 1% of the parameters of existing networks. For the BraTS 2018 validation dataset, its Dice values were 0.8726, 0.9363, 0.8699 and 0.8116 on average, WT, TC and ET, respectively, and its Hausdorff95 distances values were 3.9514, 4.3960, 3.0607 and 4.3975, respectively, which was not inferior to the existing networks and showed that it can achieve balanced recognition of each region.

Conclusion:
LFU-Net can be used as a lightweight and effective method in the segmentation tasks of two and multiple classification medical imaging datasets.
A Review of the Construction of the Nanomaterial & Nanocomposite
Based Biosensor for Different Applications
Authors: Munshe Fahad , Khan Md. Arifur Rahman 
Published: June 2022

Abstract:
The heightened attention to food and health safety has prompted researchers to conduct extensive research on biosensors that quickly detect foodborne microbial toxins and pathogens. Biosensors are
a blessing due to their simple, cost-effective technique, but there are still some drawbacks with detection
time, detection limit, and resilience. Incorporating functionalized nanomaterials into developing biosensors as catalytic tools, immobilization platforms, or optical or electroactive labels has added a new dimension to addressing these challenges. This review paper aims to discuss the construction of different types
of nanomaterial-based biosensors in food safety, exosome detection and finally, cancer detection, as well
as highlights the advantages of these biosensors over traditional techniques. In addition, a comparative
study between the nanomaterial-based biosensors taking into account the linear range and limits of detectionin these mentioned applications was also conducted. Hence, this paper provides key insights into designing and fabricating biosensors utilizing nanomaterials and opens new avenues in disease and food
safety research.
Convalescent Plasma the Experience and Journey from Blockbuster
to Incognito: A Single Centre Experience
Authors: Negi Gita , Kaur Daljit , Jain Ashish , Mohan Yatendra Kumar , Meinia Sushant Kumar , Kaur Pandeep , Panda Prasan Kumar , Kalita Deepjyoti , Ravikant  
Published: June 2022

Background:
Convalescent plasma has been used to provide passive immunotherapy
to patients with COVID-19 with a high level of safety. Very few efficacy studies
were available, and due to COVID being a relatively new disease, its exact therapeutic
role was unclear. This observational study on the impact of COVID convalescent plasma
(CCP) on clinical outcomes attempts to evaluate the effectiveness of convalescent
COVID-19 plasma therapy in the treatment of COVID-19 patients at the tertiary care
center in the Uttarakhand state of India.

Methods:
CCP was collected by plasmapheresis/whole blood from willing COVIDrecovered
donors who underwent pre-donation testing including ABO and RhD grouping,
mandatory blood screening tests for HIV, HBV, HCV, syphilis and Malaria, Haemoglobin
estimation and COVID IgG assay. Hospitalized patients with severe COVID-19 pneumonia
who received these CCP units were followed up and the outcome (Recovery/death) was
observed.

Results:
A total of 63 patients who received CCP were included in the study. Out of the
total, 13 (20.7%) were females and 50 (79.3%) were males and their ages ranged from 24
to 80 years with a median age of 53 years. The period between the start of symptoms and
hospitalization ranged from 1 to 14 days with an average duration of 4.7 days. Symptoms
on presentation included Fever 53/63 (84.1%), Tachypnoea 60/63 (95.2%) and Cough
42/63 (66.7%). Among these patients, 22/63 (34.9%) were on non-invasive ventilation
(NIV), 6/63 (9.5%) on non-rebreather mask (NRBM) and 32/63 (50.8%) were on Ventilator
support. The infused convalescent plasma had a Mean IgG value of 57.3 AU with a
range of (10-142 AU). A total of 37 (58.7%) patients were lost to COVID-19 infection
and 26 (41.3%) were discharged from the hospital in a healthy state.

Conclusion:
The use of convalescent plasma in addition to standard treatment in our
study on patients with severe pneumonia due to COVID-19 did not demonstrate reduced
mortality of COVID-19 patients amidst numerous variables. The results showed that the
use of convalescent plasma as a treatment option in the present conditions needs a serious
re-evaluation. Studies on a strictly defined recipient group and transfusion of CCP
units, with adequate antibody titer and/or neutralization activity, must be analyzed for
future works.
GREEN BUSINESS PERFORMANCE BASED CSR (Evidences from Large Scale Enterprises in Indonesia)
Authors: yoestini yoestini , Batu Kardison Lumban , Kusumawardani Amie , Andriyansah Andriyansah 
Published: June 2022

The role of CSR is world-wide recognized could enhance business performance and became a key strategy to achieve and maintain sustainable competitive advantage. Current research investigates empirically the impact of Top Management Support Advantages (TMSA), Price Advantages (PA), Product Development Advantages (PDA), Distribution Advantages (DA) and Marketing Communication Advantages (MCA) on Green Business Performance (GBP) mediated by Green Corporate Image Based Social Corporate Advantages. Deploying Structural Equation Modelling with AMOS software, Non-stratified random sampling with purposive sampling was employed for data collecting. A survey was conducted in Indonesia and Large Scale Enterprises as the object and Marketing and Operational managers as the unit analysis. The findings demonstrate/suggest that CSR strengthen the relationship among the factor drivers on GBP. CSR is considered a strategy to link with improved marketing performance. this research believes with CSR with megimplementasikan green image strategy of companies care for the environment is increasing, obviously this is also a business strategy that is widely used by companies in various parts of the world.