bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of human disturbance on flight response and habitat use of red deer
Authors: Meisingset Erling L. , Gusevik Joar , Skjørestad Atle , Brekkum Øystein , Mysterud Atle , Rosell Frank 
Published: November 2022

AbstractMany wild animals perceive humans as predators, and human disturbance, especially in the form of hunting, triggers antipredatory behavior among prey. Yet, knowledge of how game species react to different types of human disturbance and adapt to repeated disturbances is limited. We investigated how disturbance in the form of a solitary human approacher (stalker) impacted behavior (flight response and short‐term habitat use) of 28 GPS‐collared red deer (Cervus elaphus) in two populations with contrasting population densities in Norway. We studied how the behavioral response differed: (1) with season (pre‐hunting vs. hunting); (2) by consecutive approaches within a day; (3) among replicated experiments within the same season; and (4) between two regions with contrasting densities of red deer. The average flight initiation distance (FID) increased by 15% during the hunting season, and consecutive approaches within the same day caused the red deer to move 49% longer distances. Flight initiation distance was longer in the high‐density population, while escape distance was longer in the low‐density population. Red deer moved out of their weekly home range after 52% approaches, and after the onset of hunting season, time spent outside the home range increased by 89%. Red deer preferred denser resting sites after the disturbance and animal sites had shorter sighting distance and higher canopy cover than control plots. Tree density and canopy cover at animal sites increased at the onset of hunting season, from first to second approach within day, and after replicated experiments within season. Our results suggest that red deer preferred dense resting sites, especially in the hunting season. However, these animal sites had the same amount of the favorable forage plant bilberry (Vaccinium myrtillus), indicating no clear food–cover trade‐off in selection of habitat. Our study showed that onset of hunting initiates stronger fear responses in red deer, which may in turn affect red deer distribution and harvesting efficiency.
A Logic Fluorescent Chemosensor Based on Eu3+ Functionalized Cd‐MOFs for Sensing Fe3+ and Cu2+ Synchronously
Authors: Li Pengcheng , Chen Xiaohuan , Guo Cui , Zou Huijing , Chen Ziyi , Liu Bingjie , Liang Wenjie , Cai Jianfeng , Xu Hai 
Published: November 2022

AbstractOne of the most critical and yet unsolved issues is the effective monitoring of multiple heavy metal ions in complex systems through their specific function in fluorescence detection. In this work, luminescence‐active cadmium base metal‐organic frameworks (Cd‐MOFs) based on the planar and rigid π‐conjugated structure ligand benzo‐(1,2;3,4;5,6)‐tris (thiophene‐2’‐carboxylic acid) (H3BTTC) was chosen. A series of sensing experiments demonstrated that the Cd‐MOFs exhibits selective and sensitive response for Fe3+ and Eu3+ through fluorescence “turn off” and “antenna effect” respectively. In addition, the encapsulation of Eu3+ inside the Cd‐MOFs (Eu3+@Cd‐MOFs) led to an excellent probe with dual emission. To this end, a programmable fluorescence platform was developed to detect Fe3+ and Cu2+, in which the emission peaks of both the ligand and Eu3+ are completely quenched by Fe3+. The ratiometric detection of Cu2+ leads to a decrease in Eu3+ emission, while the ligand emission remains stable. To demonstrate the strategy, the fluorescence (Output) of Cd‐MOFs, Eu3+@Cd‐MOFs, and the analytes (Eu3+, Fe3+, and Cu2+, input) achieved elementary Boolean logic operations (OR, NOR, AND) and they constitute a logic fluorescent chemosensor to analyze Fe3+ and Cu2+ synchronously.
There are higher levels of conspiracy beliefs in more corrupt countries
Authors: Alper Sinan 
Published: November 2022

AbstractIn four studies, I found evidence that people living in countries with higher levels of corruption have a greater tendency for conspiracy ideation. In Study 1 (21 countries, N = 20,207), participants living in more corrupt countries reported having higher COVID‐19 and generic conspiracy beliefs. Study 2 (25 countries, N = 4935), Study 3 (25 countries, N = 24,424), and Study 4 (24 countries, N = 5973) replicated the same finding. Internal meta‐analysis suggested that this association remained significant after adjusting for other relevant cross‐country differences. Studies 1 and 2, but not 3 and 4, also showed that corruption moderated the association between individuals’ gullibility (i.e., lack of education) and their conspiracy beliefs, and this association was significant only in low‐corruption countries. The findings suggest that country‐level corruption breeds conspiracy beliefs and moderates the effect of individuals’ gullibility on conspiracy beliefs.
Interpersonal attribution bias and social evaluation in adolescent eating disorders
Authors: Harper Jessica A. , Palka Jayme M. , McAdams Carrie J. 
Published: November 2022

AbstractObjectiveImproved understanding of adolescent eating disorders (EDs), including identification and refinement of treatment and recovery targets, may help improve clinical outcomes. Interpersonal function is a proposed risk and maintenance factor that may be particularly relevant given the significance of adolescence for both psychosocial development and ED onset. This study examined self‐referential thinking in adolescents with EDs compared to healthy adolescents.MethodTwenty‐nine adolescents with EDs and 31 healthy controls completed a self‐report measure of interpersonal attributions as well as a verbal appraisal task that required conducting direct and indirect evaluations about oneself and direct evaluations about others.ResultsThe ED group had a more negative self‐attribution bias than the control group (p = 0.006) even when controlling for depression severity. Additionally, the ED group exhibited less positive direct self (p < 0.001), direct social (p = 0.015), and social reflected self‐appraisals (p = 0.011) than the healthy cohort. After including depression as a covariate in the verbal appraisal model, the model was no longer significant, suggesting group differences related to social appraisals may be mediated by depression.ConclusionsAdolescents with EDs have more negative interpersonal beliefs than comparison adolescents. Future studies are needed to determine how the constructs identified here relate to clinical course.
Ecological Risk Analysis for Benzalkonium Chloride, Benzethonium Chloride, and Chloroxylenol in US Disinfecting and Sanitizing Products
Authors: Fuchsman Phyllis , Fetters Kyle , O'Connor Alison , Bock Michael , Henning Miranda , Brown Lauren , Mrdjen Igor , Stanton Kathleen 
Published: November 2022

Abstract
Use of three topical antiseptic compounds—benzalkonium chloride (BAC), benzethonium chloride (BZT), and chloroxylenol (PCMX)—has recently increased because of the phaseout of other antimicrobial ingredients (such as triclosan) in soaps and other disinfecting and sanitizing products. Further, use of sanitizing products in general increased during the coronavirus (COVID-19) pandemic. We assessed the environmental safety of BAC, BZT, and PCMX based on best available environmental fate and effects data from the scientific literature and privately held sources. The ecological exposure assessment focused on aquatic systems receiving effluent from wastewater-treatment plants (WWTPs) and terrestrial systems receiving land-applied WWTP biosolids. Recent exposure levels were characterized based on environmental monitoring data supplemented by modeling, while future exposures were modeled based on a hypothetical triclosan replacement scenario. Hazard profiles were developed based on acute and chronic studies examining toxicity to aquatic life (fish, invertebrates, algae, vascular plants) and terrestrial endpoints (plants, soil invertebrates, and microbial functions related to soil fertility). Risks to higher trophic levels were not assessed because these compounds are not appreciably bioaccumulative. The risk analysis indicated that neither BZT nor PCMX in any exposure media is likely to cause adverse ecological effects under the exposure scenarios assessed in the present study. Under these scenarios, total BAC exposures are at least three times less than estimated effect thresholds, while margins of safety for freely dissolved BAC are estimated to be greater than an order of magnitude. Because the modeling did not specifically account for COVID-19 pandemic–related usage, further environmental monitoring is anticipated to understand potential changes in environmental exposures as a result of increased antiseptic use. The analysis presented provides a framework to interpret future antiseptic monitoring results, including monitoring parameters and modeling approaches to address bioavailability of the chemicals of interest. Environ Toxicol Chem 2022;41:3095–3115. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Abstract
Conceptual model of ecological exposures for down-the-drain usage of topical antiseptic compounds.
Strategies to increase connectivity and performance of VANETs: Analysis of route lifetime and routing protocol proposal
Authors: de Assis Danilo Renato , Alves Junior Joilson , Wille Emilio Carlos Gomes 
Published: November 2022

AbstractVehicular ad hoc networks aim to provide communication among vehicles, providing safety and entertainment to passengers. The performance of these networks is entirely dependent on the existence of routes and the time they remain established (the route lifetime). Several factors can influence route lifetime and network connectivity, for instance: speed, density, direction of movement, and radio transmission range. The investigation of route lifetime and what are the critical physical factors, can assist in building more appropriate protocols and applications, developing efficient mobile communication infrastructures. Therefore, this article proposes strategies to increase the performance of V2V vehicular networks, through the analysis of which factors most influence performance and the development of a new routing protocol, which based on these factors, is able to select the best routes. The simulations prove that the route lifetime increases in denser networks and when vehicle movement occurs in the same direction. Meanwhile, the route lifetime does not undergo significant changes depending on the speed of vehicles. Based on these results, the Improved Connectivity Ad Hoc On‐Demand Multipath Distance Vector (IC_AOMDV) protocol was developed which, without the use of any fixed infrastructure (eg, GPS), surpassed the classic AOMDV and AODV protocols in all metrics tested.
Dysregulation of global circular RNA abundance regulated by spliceosomes predicts prognosis in hepatocellular carcinoma
Authors: He Lei , Qiu Liman , Chen Feng , Chen Tingting , Peng Fang , Li Zhenli , Dong Xiuqing , Cai Zhixiong , Fang Yuanchang , Chen Hengkai , Chen Geng , Liu Xiaolong 
Published: November 2022

Abstract
CircRNAs have been reported to play crucial roles in tumor progression and recurrence, showing potential as biomarkers in cancer. However, the global abundance of circRNA and their involvement in hepatocellular carcinoma (HCC) development have not been fully explored. Whole transcriptome sequencing was performed on tumor and peritumor from 60 patients with HCC to quantify the expression of circRNAs, and the global circRNA abundance was calculated by circRNA index (CRI). Gene‐set enrichment analysis and weighted gene co‐expression network analysis were used to reveal the biological signaling pathways associated with the global circRNA abundance. The correlation between the global circRNA abundance and the infiltration level of CD8+ T cells was explored by immunohistochemical assays. Small interfering RNA was used to knock down the pre–messenger RNA spliceosome in HCC cell lines to verify the regulation of spliceosome in global circRNA abundance. We found that dysregulation of global circRNA abundance in both tumor and peritumor could lead to worse prognosis. The immunohistochemical assay further revealed that the dysregulation of global circRNA abundance in both tumor and peritumor would obstruct the CD8+ T cells from invading into the tumor, which might explain its correlation with HCC prognosis. We also demonstrated that the spliceosome genes were the main factors to regulate the global circRNA abundance in HCC, and these results were also confirmed by knockdown experiments. Conclusion: This study revealed the association between the global circRNA abundance and patients' prognosis and its underlying mechanism.
Volatility spillovers during normal and high volatility states and their driving factors: A cross‐country and cross‐asset analysis
Authors: Iqbal Najaf , Bouri Elie , Liu Guangrui , Kumar Ashish 
Published: November 2022

AbstractUnderstanding the transmission of volatility across markets is essential for managing risk and financial stability, especially under crisis periods during which an extreme event occurring in one market is easily transmitted to another market. To gain such an understanding and enrich the related literature, we examine in this article the system of volatility spillovers across various equity markets and asset classes using a quantile‐based approach, allowing us to capture spillovers under normal and high volatility states. The sample period is 16 March 2011–10 November 2020 and the employed dataset comprises 12 implied volatility indices representing a forward‐looking measure of uncertainty of global equities, strategic commodities and the US Treasury bond market. The results show that the identity of transmitters and receivers of volatility shocks differ between normal and high volatility states. The US stock market is at the centre of volatility spillovers in the normal volatility state. European and Chinese stock markets and strategic commodities (e.g. crude oil and gold) become major volatility transmitters in the high volatility state, after acting as volatility receivers during normal periods. Furthermore, we study the drivers of implied volatility spillovers using regression models and find that US Default spread contributes to the total volatility spillover index in both volatility states, whereas TED spread plays a significant role in the normal volatility state. As for the role of short rate and risk aversion, it is significant in the high volatility state. These findings matter to the decision‐making process of risk managers and policymakers.
HU308 Mitigates Osteoarthritis by Stimulating Sox9-Related Networks of Carbohydrate Metabolism
Authors: Carmon Idan , Zecharyahu Lital , Elayyan Jinan. , Meka Sai R. K. , Reich Eli , Kandel Leonid , Bilkei-Gorzo Andras , Zimmer Andreas , Mechoulam Raphael , Kravchenko-Balasha Nataly , Dvir-Ginzberg Mona 
Published: November 2022

ABSTRACT
Osteoarthritis (OA) is characterized by progressive, irreversible erosion of articular cartilage accompanied by severe pain and immobility. This study aimed to assess the effect and mechanism of action of HU308, a selective cannabinoid receptor type 2 (CB2) agonist, in preventing OA-related joint damage. To test the assumption that HU308 could prevent OA-related joint damage, Cnr2 null mice and wild type (WT) mice were aged to reach 20 months and analyzed for joint structural features. OA was induced in WT mice via a post-traumatic procedure or aging, followed by HU308 local (intra-articular) or systemic (intraperitoneal) administration, respectively. Additional analyses of time and dose courses for HU308 were carried out in human primary chondrocytes, analyzed by RNA sequencing, RT-PCR, chromatin immunoprecipitation, and immunoblotting. Our results showed that Cnr2 null mice exhibited enhanced age-related OA severity and synovitis compared to age-matched WT mice. Systemic administration of HU308 to 16-month-old mice improved pain sensitivity and maintained joint integrity, which was consistent with the intra-articular administration of HU308 in post-traumatic OA mice. When assessing human chondrocytes treated with HU308, we uncovered a dose- and time-related increase in ACAN and COL2A1 expression, which was preceded by increased SOX9 expression due to pCREB transcriptional activity. Finally, transcriptomic analysis of patient-derived human chondrocytes identified patient subpopulations exhibiting HU308-responsive trends as judged by enhanced SOX9 expression, accompanied by enriched gene networks related to carbohydrate metabolism. Collectively, the results showed that HU308 reduced trauma and age-induced OA via CB2-pCREB dependent activation of SOX9, contributing to augmented gene networks related to carbohydrate metabolism. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Silencing of lncRNA MIR31HG promotes nasopharyngeal carcinoma cell proliferation and inhibits apoptosis through suppressing the PI3K/AKT signaling pathway
Authors: Feng Bo , Chen Ke , Zhang Weiwei , Zheng Qi , He Yong 
Published: November 2022

AbstractBackgroundMIR31HG has been affirmed to regulate the tumorigenesis of head–neck squamous cell carcinoma (HNSC). This study aims to reveal the function of MIR31HG in nasopharyngeal carcinoma (NPC), which falls into the category of HNSC.MethodsMIR31HG expression pattern in HNSC tissues was predicted by starBase. FISH and qRT‐PCR were employed to detect MIR31HG expression in NPC tissues and to analyze the association between MIR31HG and clinicopathological features. NPC cell viability, colony formation, and apoptosis were measured by MTT assay, colony formation assay, and flow cytometry. The expressions of protein kinase B (AKT), phosphorylated (p)‐AKT, phosphoinositide 3‐kinases (PI3K) and p‐PI3K in NPC cells were analyzed by Western blot. The correlation between MIR31HG expression and AKT1 mRNA expression was analyzed by The Cancer Genome Atlas and starBase.ResultsMIR31HG was highly expressed in HNSC tissues and NPC tissues. Meanwhile, the association between high MIR31HG expression and aggressive clinicopathological traits was significant in NPC patients at tumor stage III‐IV (T3‐T4) and in those with lymph node metastasis 1–2 (N1‐N2). Silencing of MIR31HG suppressed NPC cell viability and colony formation, promoted apoptosis, and decreased the expressions of p‐PI3K, and p‐AKT. 740Y‐P reversed the above effects of si‐MIR31HG on NPC cells. Besides, MIR31HG expression was positively correlated with AKT1 mRNA expression in HNSC patients.ConclusionMIR31HG silencing promotes NPC cell proliferation and inhibits apoptosis through suppressing the PI3K/AKT signaling pathway.
Non‐genetic biomarkers for ankylosing spondylitis: An umbrella review
Authors: Lv Changming , Ye Ding , Zhu Yi , Meng Shuyang , Liu Bin , Sun Xiaohui , Wen Chengping , Mao Yingying 
Published: November 2022

AbstractObjectiveThe objective of the study was to provide an overview of the existing evidence on non‐genetic biomarkers for ankylosing spondylitis (AS).MethodsIn this umbrella review, we searched PubMed and Web of Science from database inception to October 31, 2020. Systematic reviews and meta‐analyses of observational studies investigating the associations between any non‐genetic biomarkers and AS were included. We estimated summary standardized mean difference (SMD) along with 95% confidence interval (CI), I2 statistic, 95% prediction interval (PI), and assessed small‐study effects and excess significance bias. The study was registered in PROSPERO with registration number of CRD42020218240.ResultsA total of 1276 publications were identified, of which 21 articles covering 43 non‐genetic biomarkers were eligible for inclusion. Evidence of 22 (51%) non‐genetic biomarkers exhibited a nominally significant effect (p < 0.05) on AS, and 7 associations (14%) showed small‐study effects. The associations of platelet count (SMD: 0.53, 95% CI: 0.36 to 0.71) and serum interleukin (IL)‐23 levels (SMD = 2.03, 95% CI: 1.27 to 2.79) with AS presented highly suggestive evidence, while circulating IL‐17 levels (SMD = 2.36, 95% CI: 1.71, 3.01) and Treg/PBMC ratio (SMD = −0.75, 95% CI: −1.06 to −0.44) presented suggestive evidence. However, these associations showed large or very large between‐study heterogeneity, suggesting an indefinite direction for the effect when 95% PIs were considered.ConclusionNo convincing evidence supported the existence of a non‐genetic biomarker for AS. Some highly suggestive associations might be affected by bias, therefore, promising non‐genetic biomarkers for AS remain limited at least based on the current evidence from observational studies.
Formative research to develop an app to prevent dating and sexual violence and alcohol use among high school youth
Authors: Edwards Katie M. , Dalla Rochelle L. , Mauer Victoria A. , Roselius Kaitlin , Camp Emily E. , Marshall Jania , Ybarra Michele 
Published: November 2022

AbstractThe purpose of this study was to conduct formative research to inform the development of an app, that would simultaneously engage youth and adults, to prevent dating and sexual violence (DSV) and alcohol use (AU). Participants (N = 56) were high school students, parents/guardians, and professionals (e.g., school personnel) from across the United States who participated in online focus groups. Overall, participants had positive perceptions of the utility, helpfulness, and effectiveness of an app to prevent DSV and AU among high school students. Participants provided in depth information about both the content (e.g., local rates of DSV and AU) and features (e.g., skills‐based, inclusion of incentives, help button) that the app should include. These preliminary data suggest that future research to develop and pilot an app for both youth and adults to prevent DSV and AU among high school students is warranted.
So far but yet so near: Examining the buffering effect of perceived social support on the psychological impact of Spanish lockdown
Authors: Dopico‐Casal Carlos , Montes Carlos , Fraga Isabel , Vieitez Lucía , Padrón Isabel , Romero Estrella 
Published: November 2022

AbstractThe main objective of this study was to examine the moderating or buffering effect of social support (SS) perceived by university students on the psychological impact of lockdown on mental health. Specifically, a total of 826 participants (622 women) completed an online survey that included standardized measures of anxiety (Generalised Anxiety Disorder‐7), depression (Patient Health Questionnaire‐9), and irritability (Brief Irritability Test), as well as measures of stressors, perceived SS, and self‐perceived change in mental health. The results of hierarchical regression analyses suggest that SS contributes toward attenuating the negative impact of academic stressors, general overload, and interpersonal conflict on the indicators of psychological well‐being; however, moderation analysis only confirms the buffering effect for symptoms of anxiety. In conclusion, it is suggested that SS networks need to be strengthened as a basic means of protecting health and well‐being during unexpected disasters.