bluuebunny/crossref_metadata_2025_split huggingface dataset:
Side-of-Implantation Effect on Functional Asymmetry in the Auditory Cortex of Single-Sided Deaf Cochlear-Implant Users
Authors: Weglage Anna , Müller Verena , Layer Natalie , Abdel-Latif Khaled H. A. , Lang-Roth Ruth , Walger Martin , Sandmann Pascale 
Published: June 2022

AbstractCochlear implants (CIs) allow to restore the hearing function in profoundly deaf individuals. Due to the degradation of the stimulus by CI signal processing, implanted individuals with single-sided deafness (SSD) have the specific challenge that the input highly differs between their ears. The present study compared normal-hearing (NH) listeners (N = 10) and left- and right-ear implanted SSD CI users (N = 10 left, N = 9 right), to evaluate cortical speech processing between CI- and NH-ears and to explore for side-of-implantation effects. The participants performed a two-deviant oddball task, separately with the left and the right ear. Auditory event-related potentials (ERPs) in response to syllables were compared between proficient and non-proficient CI users, as well as between CI and NH ears. The effect of the side of implantation was analysed on the sensor and the source level. CI proficiency could be distinguished based on the ERP amplitudes of the N1 and the P3b. Moreover, syllable processing via the CI ear, when compared to the NH ear, resulted in attenuated and delayed ERPs. In addition, the left-ear implanted SSD CI users revealed an enhanced functional asymmetry in the auditory cortex than right-ear implanted SSD CI users, regardless of whether the syllables were perceived via the CI or the NH ear. Our findings reveal that speech-discrimination proficiency in SSD CI users can be assessed by N1 and P3b ERPs. The results contribute to a better understanding of the rehabilitation success in SSD CI users by showing that cortical speech processing in SSD CI users is affected by CI-related stimulus degradation and experience-related functional changes in the auditory cortex.
Relational Quantum Mechanics is About Facts, Not States: A Reply to Pienaar and Brukner
Authors: Di Biagio Andrea , Rovelli Carlo 
Published: June 2022

AbstractIn recent works, Časlav Brukner and Jacques Pienaar have raised interesting objections to the relational interpretation of quantum mechanics. We answer these objections in detail and show that, far from questioning the viability of the interpretation, they sharpen and clarify it.
Estradiol to progesterone ratio is not a predictor of oocyte maturity at time of ovulation trigger
Authors: Berger Marisa , Patel Hency , Buyalos Richard , Hubert Gary , Wang Chumin , Shamonki Mousa , Quinn Molly 
Published: June 2022

Abstract
Purpose
To evaluate the relationship between progesterone and oocyte maturity rate via estradiol to progesterone ratio (E/P) at the time of ovulatory trigger.

Methods
This is a retrospective cohort study of first autologous IVF cycles from January to December 2018 from a private practice fertility center. Serum estradiol and progesterone levels were measured on the day of ovulatory trigger. E/P was calculated to control for degree of response. Embryos were cultured to the blastocyst stage for trophectoderm biopsy. Preimplantation genetic testing for aneuploidy (PGT-A) was performed using next-generation sequencing (NGS). Oocyte retrieval rate (oocytes retrieved/follicles ≥ 13 mm), maturity rate (MII/oocytes retrieved), and euploid rate (euploid/total biopsied embryos) were calculated. Clinical pregnancy, ongoing pregnancy (> 10 weeks), and live births following frozen embryo transfer (FET) were examined in relation to E/P. Regression analyses were performed to analyze E/P as a categorical value (defined by quartile) on oocyte maturity.

Results
Two hundred eleven women underwent controlled ovarian hyperstimulation and had steroid levels at trigger available. Mean E at trigger was 3449 ± 2040 pg/mL while mean P was 1.13 ± 0.58 ng/mL, with mean E/P of 3.36 + 2.04. There were no differences between quartiles of E/P with respect to retrieval, maturity rate, or euploid rate. Two hundred eleven IVF cycles resulted in 138 euploid frozen embryo transfers. There were no differences between quartiles of E/P with respect to clinical pregnancy, ongoing pregnancy, or live birth rate.

Conclusion
E/P ratio at the time of trigger does not impact oocyte retrieval rate, maturity rate, or euploid rate. Pregnancy and live birth outcomes were also not impacted.
A Comprehensive Framework for Saturation Theorem Proving
Authors: Waldmann Uwe , Tourret Sophie , Robillard Simon , Blanchette Jasmin 
Published: June 2022

AbstractA crucial operation of saturation theorem provers is deletion of subsumed formulas. Designers of proof calculi, however, usually discuss this only informally, and the rare formal expositions tend to be clumsy. This is because the equivalence of dynamic and static refutational completeness holds only for derivations where all deleted formulas are redundant, but the standard notion of redundancy is too weak: A clause C does not make an instance $$C\sigma $$

C
σ

redundant. We present a framework for formal refutational completeness proofs of abstract provers that implement saturation calculi, such as ordered resolution and superposition. The framework modularly extends redundancy criteria derived via a familiar ground-to-nonground lifting. It allows us to extend redundancy criteria so that they cover subsumption, and also to model entire prover architectures so that the static refutational completeness of a calculus immediately implies the dynamic refutational completeness of a prover implementing the calculus within, for instance, an Otter or DISCOUNT loop. Our framework is mechanized in Isabelle/HOL.
Time interval between the diagnosis of breast cancer and brain metastases impacts prognosis after metastasis surgery
Authors: Michel Anna , Dinger Thiemo Florin , Santos Alejandro N. , Pierscianek Daniela , Darkwah Oppong Marvin , Ahmadipour Yahya , Dammann Philipp , Wrede Karsten H. , Hense Jörg , Pöttgen Christoph , Iannaccone Antonella , Kimmig Rainer , Sure Ulrich , Jabbarli Ramazan 
Published: June 2022

Abstract
Purpose
Breast cancer (BC) is the most frequently diagnosed tumor entity in women. Occurring at different time intervals (TI) after BC diagnosis, brain metastases (BM) are associated with poor prognosis. We aimed to identify the risk factors related to and the clinical impact of timing on overall survival (OS) after BM surgery.

Methods
We included 93 female patients who underwent BC BM surgery in our institution (2008–2019). Various clinical, radiographic, and histopathologic markers were analyzed with respect to TI and OS.

Results
The median TI was 45.0 months (range: 9–334.0 months). Fifteen individuals (16.1%) showed late occurrence of BM (TI ≥ 10 years), which was independently related to invasive lobular BC [adjusted odds ratio (aOR) 9.49, 95% confidence interval (CI) 1.47–61.39, p = 0.018] and adjuvant breast radiation (aOR 0.12, 95% CI 0.02–0.67, p = 0.016). Shorter TI (< 5 years, aOR 4.28, 95% CI 1.46–12.53, p = 0.008) was independently associated with postoperative survival and independently associated with the Union for International Cancer Control stage (UICC) III–IV of BC (aOR 4.82, 95% CI 1.10–21.17, p = 0.037), midline brain shift in preoperative imaging (aOR10.35, 95% CI 1.09–98.33, p = 0.042) and identic estrogen receptor status in BM (aOR 4.56, 95% CI 1.35–15.40, p = 0.015).

Conclusions
Several factors seem to influence the period between BC and BM. Occurrence of BM within five years is independently associated with poorer prognosis after BM surgery. Patients with invasive lobular BC and without adjuvant breast radiation are more likely to develop BM after a long progression-free survival necessitating more prolonged cancer aftercare of these individuals.
Between panic and motivation: did the first wave of COVID-19 affect scientific publishing in Mediterranean countries?
Authors: Ali Mona Farouk 
Published: June 2022

AbstractDue to the ongoing COVID-19 pandemic that began in the winter of 2020, all communities and activities globally have been positively or negatively affected. This scientometric study raises an interesting question concerning whether the volume and characteristics of scientific publishing in all disciplines in 23 Mediterranean countries have been impacted by the pandemic and whether variations in the cumulative totals of COVID-19 cases have resulted in significant changes in this context. The Scopus database and SciVal tool supplied the necessary data for the years targeted for comparison (2019 and 2020), and the annual growth rates and differences were computed. The study used the Mann–Whitney test to examine the significance of the differences between the two years and the Spearman and Kendall correlation tests to evaluate the effect of the number of infections on these differences for all aspects of scientific performance. The findings demonstrated that the COVID-19 pandemic served as a powerful incentive, and the Mediterranean region experienced considerable differences in the volume and features of publications during this crisis. The most substantial implications were the significant growth from 3.1 to 9.4% in productivity and the increases in the annual growth rates of international collaboration, by 12% for the collaboration among Mediterranean countries and 10% for collaboration with the top ten epidemic countries. It was also proven that some characteristics of the publications were positively correlated with the total number of infections. This investigation can help university leaders and decision-makers in higher education and research institutions in these countries make decisions and implement measures to bridge the gaps and motivate researchers in all fields to conduct more research during this ongoing pandemic.
Well-being in Thailand: A Culturally Driven Grounded Inquiry Exploration of a Complex Construct
Authors: Suavansri Panita , Pichayayothin Nipat , Espinosa Patricia Rodriguez , Areekit Poonsub , Nilchantuk Chureerat , Jones Torin S. , French Joanna J. , Mam Emily , Moore Jessie B. , Heaney Catherine A. 
Published: June 2022

AbstractBackgroundWell-being has long been recognized as a key construct in human history. Quantitative studies have been limited in their ability to uncover contextual and cultural nuances that can be leveraged to inform the promotion of well-being. The present study employed a qualitative approach informed by narrative inquiry to understand how individuals in a rapidly developing Asian country experience what it means to be well and what contributes to or detracts from their well-being.MethodsA purposeful sample of 50 Thai adults living in Bangkok shared their personal stories of times when they experienced high and low levels of well-being. Data were inductively coded and analysed to identify key domains of participants’ well-being and their inter-connections.ResultsThe results reflect three layers of well-being. Social relationships (i.e., family, friends and acquaintances, and relationships at work or education) are at the center of well-being in Thailand, connecting and supporting a second layer of eight constituent domains of well-being (experience of emotions, sense of self, finances, self-care, demands and responsibilities, thoughts and feelings about the future, personal health, spirituality). The third layer is composed of the societal and physical contexts that are formative for well-being.ConclusionsOur findings suggest both universal and culturally unique components of well-being among Thai adults. Implications for the promotion of well-being in Thailand are discussed.
Real-time denoising of ultrasound images based on deep learning
Authors: Cammarasana Simone , Nicolardi Paolo , Patanè Giuseppe 
Published: June 2022

AbstractUltrasound images are widespread in medical diagnosis for muscle-skeletal, cardiac, and obstetrical diseases, due to the efficiency and non-invasiveness of the acquisition methodology. However, ultrasound acquisition introduces noise in the signal, which corrupts the resulting image and affects further processing steps, e.g. segmentation and quantitative analysis. We define a novel deep learning framework for the real-time denoising of ultrasound images. Firstly, we compare state-of-the-art methods for denoising (e.g. spectral, low-rank methods) and select WNNM (Weighted Nuclear Norm Minimisation) as the best denoising in terms of accuracy, preservation of anatomical features, and edge enhancement. Then, we propose a tuned version of WNNM (tuned-WNNM) that improves the quality of the denoised images and extends its applicability to ultrasound images. Through a deep learning framework, the tuned-WNNM qualitatively and quantitatively replicates WNNM results in real-time. Finally, our approach is general in terms of its building blocks and parameters of the deep learning and high-performance computing framework; in fact, we can select different denoising algorithms and deep learning architectures.
Resilience of Neural Electronics to High Magnetic Fields
Authors: Graham-Harper-Cater Jonathan , Nogaret Alain , Blakes Hugh , Metcalfe Ben , Taylor John 
Published: June 2022

AbstractWith the advent of neuronal oscillators in bioelectronic medicine, it has become increasingly important to understand the effect of magnetic fields on the biological rhythms they produce. In particular, cardiac pacemakers must be resilient to the magnetic fields applied during magnetic resonance imaging, but it is not known whether the nonlinearity of the neuron response would amplify some the known effects of magnetic fields in semiconductor devices. Here, we have performed a series of experiments probing the oscillations of a silicon neuron in a static magnetic field of 3T applied in the plane of the substrate and perpendicular to it. The neuron was fabricated from complementary metal-oxide-semiconductor integrated circuits, which integrated currents in the nA range to compute the output of the Hodgkin-Huxley model. The experiment reveals a small magnetic field-induced dephasing of neuron oscillations which is slightly larger when the magnetic field is in the plane rather than perpendicular to the plane. This is interpreted in terms of the differences in diffusion coefficients of cyclotron and magnetoelectric skipping orbits at room temperature.
Quantum cohomology as a deformation of symplectic cohomology
Authors: Borman Matthew Strom , Sheridan Nick , Varolgunes Umut 
Published: June 2022

AbstractWe prove that under certain conditions, the quantum cohomology of a positively monotone compact symplectic manifold is a deformation of the symplectic cohomology of the complement of a simple crossings symplectic divisor. We also prove rigidity results for the skeleton of the divisor complement.
An avenue to miscarriage: a case report
Authors: Grey S. , Lartey J. , Millington J. , Vardon R. , Crane J. , Preuß-Wössner J. , Buschmann C. 
Published: June 2022

AbstractTwo men were wrongfully convicted of murder in 2017 and sentenced to life imprisonment. After a physical altercation inside a flat, the victim (A) was found dead approximately 60 m away outside a residential address. He had sustained a number of injuries including a stab wound to the left side of his neck which was found to have divided the right carotid artery. The location where A was found was not regarded as a crime scene and not subjected to a specialist forensic examination by scientists as it was assumed that the fatal injury was sustained in the flat. The pathologist, who subsequently carried out the autopsy on A, was not asked to attend the scene. A review of the blood distribution at the scene in conjunction with the pathology findings indicated however that the fatal neck wound had been inflicted outside the flat, near to where the victim was found. An appeal against the convictions for murder was upheld in 2021 and a re-trial ordered. Following this second trial, both accused were acquitted of murder and released from custody. The new pathology and blood pattern evidence introduced at the second trial was a major part of the defense strategy which led to the acquittal of the accused. The case illustrates that a more inclusive and detailed crime scene strategy had been undertaken, including an assessment of the bloodstains present, in conjunction with discussion with the pathologist, then the likelihood is that the two men subsequently charged with murder would have been eliminated as suspects and a miscarriage of justice would have been avoided.
Trivializable and Quaternionic Subriemannian Structures on $${\mathbb {S}}^7$$ and Subelliptic Heat Kernel
Authors: Bauer Wolfram , Laaroussi Abdellah 
Published: June 2022

AbstractOn the seven dimensional Euclidean sphere$${\mathbb {S}}^7$$S7we compare two subriemannian structures with regards to various geometric and analytical properties. The first structure is called trivializable and the underlying distribution$${\mathcal {H}}_T$$HTis induced by a Clifford module structure of$${\mathbb {R}}^8$$R8. More precisely,$${\mathcal {H}}_T$$HTis rank 4, bracket generating of step two and generated by globally defined vector fields. The distribution$${\mathcal {H}}_{Q}$$HQof the second structure is of rank 4 and step two as well and obtained as the horizontal distribution in the quaternionic Hopf fibration$${\mathbb {S}}^3\hookrightarrow {\mathbb {S}}^7\rightarrow {\mathbb {S}}^4$$S3↪S7→S4. Answering a question in: Markina and Godoy Molina (Rev Mat Iberoam 27(3), 997–1022, 2011) we first show that$${\mathcal {H}}_{Q}$$HQdoes not admit a global nowhere vanishing smooth section. In both cases we determine the Popp measures [20], the intrinsic sublaplacians$$\Delta _{\text {sub}}^T$$ΔsubTand$$\Delta _{\text {sub}}^{Q}$$ΔsubQand the nilpotent approximations. We conclude that both subriemannian structures are not locally isometric and we discuss properties of the isometry group. By determining the first heat invariant of the sublaplacians it is shown that both structures are also not isospectral in the subriemannian sense.
Neumann Eigenvalues of the Biharmonic Operator on Domains: Geometric Bounds and Related Results
Authors: Colbois Bruno , Provenzano Luigi 
Published: June 2022

AbstractWe study an eigenvalue problem for the biharmonic operator with Neumann boundary conditions on domains of Riemannian manifolds. We discuss the weak formulation and the classical boundary conditions, and we describe a few properties of the eigenvalues. Moreover, we establish upper bounds compatible with the Weyl’s law under a given lower bound on the Ricci curvature.
Major adverse cardiovascular events in older emergency department patients presenting with non-cardiac medical complaints
Authors: Zelis N. , Roumans-van Oijen A. M. M. , Buijs J. , van Kraaij D. J. W. , van Kuijk S. M. J. , de Leeuw P. W. , Stassen P. M. 
Published: June 2022

Abstract
Objective
The risk of major adverse cardiovascular events (MACE) for older emergency department (ED) patients presenting with non-cardiac medical complaints is unknown. To apply preventive measures timely, early identification of high-risk patients is incredibly important. We aimed at investigating the incidence of MACE within one year after their ED visit and the predictive value of high-sensitivity cardiac troponin T (hs-cTnT) and N‑terminal pro-B-type natriuretic peptide (NT-proBNP) for subsequent MACE.

Methods
This is a substudy of a Dutch prospective cohort study (RISE UP study) in older (≥ 65 years) medical ED patients who presented with non-cardiac complaints. Biomarkers were measured upon ED arrival. Cox-regression analysis was used to determine the predictive value of the biomarkers, when corrected for other possible predictors of MACE, and area under the curves (AUCs) were calculated.

Results
Of 431 patients with a median age of 79 years, 86 (20.0%) developed MACE within 1 year. Both hs-cTnT and NT-proBNP were predictive of MACE with an AUC of 0.74 (95% CI 0.68–0.80) for both, and a hazard ratio (HR) of 2.00 (95% CI 1.68–2.39) and 1.82 (95% CI 1.57–2.11) respectively. Multivariate analysis correcting for other possible predictors of MACE revealed NT-proBNP as an independent predictor of MACE.

Conclusion
Older medical ED patients are at high risk of subsequent MACE within 1 year after their ED visit. While both hs-cTnT and NT-proBNP are predictive, only NT-proBNP is an independent predictor of MACE. It is likely that early identification of those at risk offers a window of opportunity for prevention.
Binnensporten tijdens de COVID-19-pandemie: analyse met behulp van data uit de COVID RADAR app
Authors: van Dijk Willian J. , Saadah Nicholas H. , Numans Mattijs E. , Kiefte-de Jong Jessica C. 
Published: June 2022

SamenvattingBinnensportaccommodaties werden langer gesloten gehouden dan buitensportaccommodaties gedurende de lockdowns tijdens de COVID-19-pandemie. Dit onderzoek beantwoordt de vraag of binnen sporten het risico op besmetting met SARS-CoV‑2 vergroot. Hiervoor werden gegevens gebruikt van de COVID RADAR-app. Er werd gecorrigeerd voor leeftijd, vaccinatiestatus, geslacht, ander risicogedrag, prevalentie van SARS-CoV‑2 en kwaliteit van de leefomgeving. Uit analyses van 1.353 gebruikers, van wie 13,0% een positieve testuitslag rapporteerde, blijkt dat binnensporters significant vaker een positieve test hadden (oddsratio 1,8; 95%-betrouwbaarheidsinterval 1,2–2,6; p = 0,003) ten opzichte van gebruikers die buiten sporten. Dit bevestigt de rationale achter het eerdere beleid ten aanzien van het langer gesloten houden van binnensportaccommodaties om het aantal besmettingen te reduceren.
Multi-criteria material selection for casing pipe in shale gas wells application
Authors: Mohammed Auwalu I. , Bartlett Mark , Oyeneyin Babs , Kayvantash Kambiz , Njuguna James 
Published: June 2022

AbstractThe conventional method of casing selection is based on availability and/or order placement to manufacturers based on certain design specifications to meet the anticipated downhole conditions. This traditional approach is very much dependent on experience as well as constructing oil and gas wells at minimum budget. However, this material selection approach is very limited in meeting the requirement of shale gas wells. This study utilises the material performance indices and ANSYS Granta database to examine three different casing pipe buckling scenarios including the buckling with corrosion potentials and buckling with impact and long-term service temperature conditions. Consequently, numerical evaluations of the response of the selected casing materials established the stress, deformations, and safety factor for the first scenario (shale gas well with buckling tendencies). The significance of this new method is added advantage in terms of integrating materials’ physicochemical, thermal and mechanical properties and the casing functional performance to establish ideal selection within the design space or requirements. Results obtained in this study show that there are optional materials that outperform the most common casing grades (P110 and Q125) utilised in shale gas development in terms of both safety and cost. This study established a procedure for evaluating optimum performance between cost, safety, performance indices and materials’ physical and mechanical properties for a typical well design scenario. This procedure will assist the design engineer to justify the selection of a particular material(s) safely and technically for a given shale well casing application in future. In all the 10 materials investigated, even though the P110 (API casing grade) meets the buckling design scenario and widely used in shale gas well development, there are many alternative viable material candidate options that outperform P110 Grade with the best material candidate studied in this work being BS 145.