bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model Investigasi Berbantuan Geogebra pada Geometri Bidang
Authors: Maulidiya Della , Susanta Agus , Irsal Nur Aliyyah 
Published: January 2022

Tujuan penelitian yang diulas dalam artikel ini yaitu mendeskripsikan hasil identifikasi aktivitas-aktivitas investigasi berbantuan Geogebra yang dilakukan mahasiswa S1 Pendidikan Matematika Universitas Bengkulu untuk memecahkan masalah-masalah geometri bidang. Permasalahan yang diberikan pada mahasiswa meliputi konstruksi garis tinggi segitiga, konstruksi berbagai jenis segiempat, dan konstruksi segitiga dengan keliling terkecil dimana segitiga itu dibentuk dari titik-titik pada masing-masing sisi sebuah segitiga. Hasil penelitian menunjukkan mahasiswa melakukan investigasi berbantuan Geogebra dengan tahapan sebagai berikut: membaca berulang kali permasalahan untuk mengidentifikasi informasi yang dibutuhkan dan permasalahan yang harus diselesaikan, menuliskan kembali permasalahan dengan bahasa sendiri sehingga dapat menuliskan secara sistematis langkah-langkah investigasi, membandingkan proses konstruksi manual dan berbantuan Geogebra yang pernah dilakukan untuk menyelesaikan permasalahan baru, mengidentifikasi sifat dan prinsip obyek geometri yang sesuai dengan permasalahan konstruksi, dan melakukan strategi coba-coba (trial and error) untuk menyelesaikan permasalahan.
Peningkatan Kemampuan Pemahaman Konsep Matematis melalui Model Kooperatif Tipe Scramble dengan Pendekatan Kontekstual Pada Materi Segiempat dan Segitiga di Kelas VII
Authors: Chairunnisa Inayatusufi  , Hakim Lukman El , Sari Puspita 
Published: January 2022

Tujuan penelitian ini untuk mengetahui penerapan pembelajaran kooperatif tipe scramble dengan pendekatan kontekstual dalam meningkatkan kemampuan pemahaman konsep matematis siswa pada segiempat dan segitiga kelas VII. Penelitian PTK ini dilaksanakan dalam tiga siklus yang terdiri dari perencanaan, pelaksanaan, observasi, analisis dan refleksi. Subjek penelitian (SP) sebanyak 6 siswa kelas VII MTsN 16 Jakarta. Penelitian ini menerapkan tahapan model kooperatif scramble dan tujuh komponen kontekstual. Setiap pertemuan siswa diberikan LKS sebagai perangkat pembelajaran yang berisi pertanyaan pemandu sebagai wujud kegiatan inkuri, sehingga siswa dapat menemukan konsep yang sedang dipelajari yang disesuaikan dengan indikator kemampuan pemahaman konsep. Hasil penelitian menyatakan bahwa kemampuan pemahaman konsep matematis siswa mengalami peningkatan. Hal tersebut dilihat dari proses siswa dalam mengikuti kegiatan pembelajaran dan juga peningkatan nilai rata-rata tes siklus SP. Hasil siklus I sebesar 78,56, siklus II 88,68 dan siklus III sebesar 93,44. Sehingga dapat disimpulkan bahwa model pembelajaran kooperatif tipe scramble dengan pendekatan kontekstual dapat meningkatkan kemampuan pemahaman konsep matematis pada segiempat dan segitiga.
High Tibial Osteotomies for the Treatment of Osteoarthritis of the Knee
Authors: Kanakamedala Ajay C. , Hurley Eoghan T. , Manjunath Amit K. , Jazrawi Laith M. , Alaia Michael J. , Strauss Eric J. 
Published: January 2022

» A high tibial osteotomy (HTO) is a joint-preserving procedure that can be used to treat symptomatic unicompartmental cartilage disorders in the presence of limb malalignment.» Appropriate patient selection and careful preoperative planning are vital for optimizing outcomes.» Based on past literature, correction of varus malalignment to 3° to 8° of valgus appears to lead to favorable results. Recently, there has been growing awareness that it is important to consider soft-tissue laxity during preoperative planning.» Although there has been a recent trend toward performing opening-wedge rather than closing-wedge or dome HTOs for unicompartmental osteoarthritis, current data suggest that all 3 are acceptable techniques with varying complication profiles.» Based on current evidence, an HTO provides pain relief, functional improvement, and a high rate of return to sport, with reported survivorship ranging from 74.7% to 97.6% and 66.0% to 90.4% at 10 and 15 years, respectively.
Traducción automática y posedición en el aula de doblaje: resultados de una experiencia docente
Authors: Mejías-Climent Laura , De los Reyes Lozano Julio 
Published: January 2022

El interés por la traducción automática (TA) y la posedición (PE) avanza a pasos agigantados y cada vez son más las especialidades de traducción que tratan de incorporarlas a su entorno profesional, sobre todo en la rama de la traducción técnica y en algunos géneros jurídicos. La TA comienza poco a poco a intersectar también con la traducción audiovisual (TAV), una disciplina de la que tradicionalmente ha permanecido alejada, debido a la dificultad para procesar plenamente la información del texto audiovisual. A pesar de tratarse de proyectos aún incipientes y principalmente en la modalidad de subtitulación, se espera que en un futuro no muy lejano se avance en los procesos tecnológicos y se profundice en el necesario etiquetado y preparación del texto de partida para su traducción mediante TA atendiendo a las particularidades de otras modalidades de TAV, como el doblaje o las voces superpuestas.
En este artículo se presentan los resultados de una experiencia docente en el aula de doblaje que buscaba explorar las posibilidades de aplicación de varias herramientas de TA de libre acceso a la traducción para doblaje. Para ello, 40 estudiantes de último curso realizaron dos tareas de traducción, una humana y otra mediante TA y PE, en las que se evaluó el tiempo empleado y los errores generados por la TA. Los resultados apuntan hacia una considerable dificultad de aplicación de la TA en la modalidad de doblaje que, no obstante, cabría seguir explorando mediante la incorporación de la PE en la fase de ajuste del guion de doblaje.
Study on the Evolution Law of Shale Hydraulic Fracture Interacting with Bedding Layer under Pulsation Loading
Authors: Suo Yu , Zhang Jiu , Feng Fuping , Ji Jinzhong , Ye Qinyou , Yang Lianhang 
Published: January 2022

Abstract
The bedding layers in shale reservoirs are highly developed with numerous bedding joints. In the hydraulic fracturing process, the propagation of hydraulic fractures during shale formation significantly affects the efficient development of reservoirs. In this study, we employed the pulsating cyclic loading technique to develop a model of the interaction between shale hydraulic fractures and bedding layer; in addition, we used a numerical model optimization method for the zero-thickness cohesive element to compare the hydraulic fracture and bedding layer propagation behavior under static and pulsating loading. We studied the propagation behavior of pulsating fracturing bedding layers at different frequencies, amplitudes, and bedding angles. The results revealed that static load fracturing is more conducive to the propagation of primary fracture under the same conditions, and that pulsation fracturing is better for the propagation of bedding layer. The higher frequency and amplitude of the seismic source in the pulsation fracturing process are more favorable to crossing the bedding layers. When the bedding angle is approximately 10°, turning the main fracture along the bedding direction is challenging. The hydraulic fracture along bedding layer propagation was achieved when the bedding angle was approximately 30° and 45°. When the bedding angle was approximately 60° or more, the fracture extended only along one side of the bedding layer. The study results provide guidance for the formation of fracture networks in the field of fracturing construction of shale reservoirs, thus improving the production of shale reservoirs.
Production Splitting Method for Commingled Production Reservoir Based on Automatic History Matching of Single Well
Authors: Sui Yingfei , Cui Chuanzhi , Wang Zhen , Yang Yong , Jia Peifeng 
Published: January 2022

Abstract
The interlayer interference is very serious in the process of water flooding development, especially when the reservoir adopts commingling production. The implementation of various interlayer interference mitigation measures requires that the production performance parameters and remaining oil distribution of each layer of the reservoir should be clearly defined, and the accurate production splitting of oil wells is the key. In this paper, the five-spot pattern is simplified to a single well production model of commingled production centered on oil well. The accurate production splitting results are obtained through automatic history matching of single well production performance. The comparison between the calculation results of this method and that of reservoir numerical simulation shows that the method is simple, accurate, and practical. In the field application, for the multilayer commingled production reservoir without accurate numerical simulation, this method can quickly and accurately realize the production splitting of the reservoir according to the development performance data.
Estimation of the Squirt-Flow Length Based on Crack Properties in Tight Sandstones
Authors: Wu Chunfang , Ba Jing , Zhang Lin , Carcione José M. 
Published: January 2022

Abstract
Tight sandstones have low porosity and permeability and strong heterogeneities with microcracks, resulting in small wave impedance contrasts with the surrounding rock and weak fluid-induced seismic effects, which make the seismic characterization for fluid detection and identification difficult. For this purpose, we propose a reformulated modified frame squirt-flow (MFS) model to describe wave attenuation and velocity dispersion. The squirt-flow length (R) is an important parameter of the model, and, at present, no direct method has been reported to determine it. We obtain the crack properties and R based on the DZ (David-Zimmerman) model and MFS model, and how these properties affect the wave propagation, considering ultrasonic experimental data of the Sichuan Basin. The new model can be useful in practical applications related to exploration areas.
Drivers of East Asian millennial-scale climate over the past 400,000 years
Authors: Kubota Yoshimi , Clemens Steven , Lee Kyung Eun , Holbourn Ann , Wakisaka Etsuko , Horikawa Keiji , Tada Ryuji , Kimoto Katsunori 
Published: January 2022

Abstract
The history of abrupt climate change in East Asia is often discussed from hydroclimate proxies that record the isotopic composition of rainfall. However, the underlying mechanisms remain obscure because water-isotope proxies respond to a wide variety of environmental variables. Here, we investigated millennial-scale climate variability in East Asia over the past 400,000 years using paired foraminiferal oxygen isotope and Mg/Ca records from the East Asian continental margin, thereby resolving variance into temperature and rainfall components. We found that the temperature and rainfall variabilities are largely asynchronous, with times when the global climate shifts from interglacial to glacial periods being the notable exception. These findings highlight the importance of both mean global state and magnitude of North Atlantic variability in determining the East Asian climate. Without a strong North Atlantic forcing, the regional feedback system might generate asynchronous temperature and rainfall variations, which is the background climate feature in East Asia.
Application of NLO and Antibacterial Activity of Tricine Doped Potassium Metal Ion Crystal
Authors: P Lalitha , S Arumugam , A Sinthiya , V Sugumari 
Published: January 2022

Abstract
We have successfully produced Tricine Potassium Nitrate (TPN) single crystal synthesis using the solution growth method in this study. The powder X-ray diffraction (PXRD) technique was used to identify the phases of TPN crystals. Fourier transform infrared (FT-IR) analysis was performed to examine the functional groups contained in the produced crystals. To measure optical transparency, a UV-VIS-NIR investigation was conducted between 200 and 800nm. TPN crystal's photoluminescence (PL) spectrum was recorded. Vickers' hardness tester was used to investigate the mechanical characteristics of the formed crystal.Thermal gravimetric/differential thermal analysis was used to investigate the thermal behaviors of the produced crystals. The surface morphology of the formed crystal was determined using a field emission scanning electron microscope. Wet etching experiments were used to investigate the TPN crystal's growth feature. The shock damage threshold technique was used to determine the shock strength at which the crystal poses a risk. The Kurtz-Perry technique was used to investigate the effectiveness of the developed crystals' second harmonic generation (SHG). The antibacterial activity of TPN grown crystal against various standard bacterial strains.
Design, Synthesis, Biological Evaluation and Molecular Docking Studies of 5-fluorouracil-dithiocarbamate Conjugates
Authors: Zhan Yifeng , Wang Youyun , Wang Puzhao , Zhu Hongda , Guo Huiling , Sun Hongmei , Liu Mingxing 
Published: January 2022

Abstract

In this paper, a series of novel 5-fluorouracil-dithiocarbamate conjugates were designed, synthesized and evaluated in vitro . The results of cytotoxicity assays illuminated that these conjugates had anti-tumor activity against B16, Hela and U87MG, and compound P3 exhibited excellent growth inhibition against U87MG cells. Interestingly, the cytotoxicity of these conjugates was significantly increased when combined with copper ions. Meanwhile, colony-formation assays, transwell migration assays, cell apoptosis assays and cell cycle distribution assays were performed to explore the anti-tumor mechanism of conjugates. Compound P3 and P4 exhibited good biological activity in above four experiments when combined with copper ions. Especially, P3 displayed better bioactivity compared to the other three compounds. These results indicated that conjugates might be metabolized in the cells to produce dithiocarbamates, then metabolites formed complexes with copper ions, generating anti-tumor effects. Furthermore, conjugates and their metabolized dithiocarbamate derivatives were investigated by molecular docking, the results exhibited that P3 had the strongest interaction with the proteins 6CCY and 5T92, which was consistent with the obtained results of cell experiments. Compound P3 might be a potential lead-compound for the treatment of breast cancer and glioma. Further research in vivo about these compounds would be performed in our following work.
E-waste Management In Indian Microscale Informal Sectors – An Environmental Perspective Towards Policy Regulation
Authors: Dasgupta Dipsikha , Majumder Santanu , Adhikari Jishnu , Ghosh Pinaki , Purchase Diane , Garelick Hemda , Debsarkar Anupam , Chatterjee Debashis 
Published: January 2022

Abstract
Inappropriate e-waste processing in the informal sector is a serious issue in developing countries. Field investigations in microscale informal recycling sites have been performed to study the impact of hazardous metal(loid)s (released from e-waste dismantling) on the environment (water and soil). Eight hazardous metal(loid)s (Pb, Cd, Cu, Zn, As, Hg, Ni and Cr) were found at elevated levels in the monitored water and soil samples (Sangrampur, West Bengal) as a consequence of widespread informal e-waste handling and primitive processing. Pd, Cu and As were found in high concentrations in water samples (1.62, 1.40, 0.03 mgL-1 respectively). Significant levels of Cu, Pd and Cd were detected in collected soil samples, both topsoil (Cu up to 2328.60 ± 217.60, Pb up to 342.90 ± 32.36 and Cd 18.34 ± 3.81 mgkg-1) and subsurface soil (2491.40 ± 276.20, 1853.33 ± 144.79, 25.90 ± 9.53 mgkg-1), compared to the levels of Zn, As, Hg, Ni and Cr. The results of seasonal variation indicated that higher levels of these hazardous meta(loids) were detected in the pre-monsoon (Nov – May) season than the rest of the year, as open dumping/burning of e-waste were practiced commonly and frequently in the monitored sites. The results highlighted that the composition and the handling of e-waste were important factors affecting the metal(loid) concentrations. E-waste policy and legislation have great influence on the handling and disposal procedures. A novel improved e-waste management practice has been proposed to encourage eco-friendly and safe e-waste disposal. It is recommended that regulatory agencies and manufacturers should create a road map to convince the informal sector to develop a systematic approach towards a more standardized formal e-waste management practices at the microscale field level.
Utilization of Frequency Ratio Method for the Development of Landslide Susceptibility Maps: Karaburun Peninsula Case, Turkey
Authors: Karaman Muhittin Ozan , ÇABUK Saye Nihan , PEKKAN Emrah 
Published: January 2022

Abstract
Geographical information systems (GIS) facilitates both current landslide mapping processes and prediction of potential landslides that may be experienced in the future. Within the scope of the study, landslide susceptibility maps were developed in order to reduce the damages of possible landslides in Karaburun Peninsula of İzmir province. To fulfil this aim, landslide inventory map was produced from related databases in the first place followed by the development of parameter (elevation, aspect, slope, curvature, land use, vegetation cover, lithology, distance to roads, distance to rivers and distance to fault lines) maps. Frequency ratio method was utilized for developing the landslide susceptibility maps and Reciever Receiver Operating Characteristic (ROC) analysis was performed for accuracy testing. The resulting landslide susceptibility map revealed that 36% and 52% of the study area had high and medium risk categories, respectively. 10% of the region has low landslide risk. These results provide important inputs to guide sustainable strategic and physical planning processes in the region, which has been formerly declared as a special protection area, and is a popular destination for both tourism activities and energy facilities.
WITHDRAWN: Effectiveness of a Cognitive-behavioral Group Therapy for Complicated Grief in Family Members of Patients With Cancer
Authors: Lacasta-Reverte Maria Antonia , Cruzado Juan Antonio 
Published: January 2022

Abstract
Introduction: complicated grief can affect a large number of individuals who have lost a relative due to cancer. Objective: to assess the efficacy of a cognitive-behavioral group therapy (CBGT) for complicated grief in those who have lost a relative due to cancer in comparison with a psychoducational and emotional expression intervention (PSDEEI).Method: 249 relatives of deceased cancer patients with complicated grief were randomly assigned to treatment with CBGT or PSDEEI. Complicated Grief (ICG), depression (BDI-II), hopelessness (BHS), anxiety (BAI) symptoms and general health (GHQ28) were assessed at pre-treatment, post-treatment, and follow-up at 6 and 12 months. Results: the CBGT group improved significantly (p<0.001), with the scores in ICG, BDI-II, BAI, BSH, and GHQ28 (p<0.001) being higher than those for the PSDEEI group in each of the assessed moments, with high effect sizes: ICG (η2=0.16), BDI (η2=0.10), BAI (η2=0.06), BSH (η2=0.21) and GHQ28 (η2=0.21). At the 12-month follow-up, the number of cases of complicated grief decreased by 81.1% for the CBGT group vs. 31.7% in the PSDEEI group. Conclusions: The CBGT treatment is effective for complicated grief, for depression, anxiety, and hopelessness symptoms and for mental health, and is superior to PSDEEI treatment.
Clinacanthus Nutans Induces Antiproliferative and Apoptosis in Human Breast Cancer Cells Through Targeted Apoptosis Pathway
Authors: Arsad Hasni , Ismail Noor Zafirah , S Salwani Md , Adebayo Ismail Abiola , T Zaleha Md , Abas Rafedah , Zain Nur Nadhirah Mohamad 
Published: January 2022

Abstract
Clinacanthus nutans dichloromethane fraction (CN-Dcm) extract has previously been proven to suppress breast cancer (MCF7) cell proliferation. Despite this, the molecular mechanisms involved in C. nutans extract-treated MCF7 cells are unknown. Hence, the molecular mechanism of apoptosis in treated MCF7 was investigated in this current study. This study was intended to subfractionate CN-Dcm extract using column chromatography and analysed the treated MCF7 cells using the CellTiter 96® AQueous One Solution Cell Proliferation (MTS) assay, Annexin V/propidium iodide (PI) assay, western blot and reverse transcription-qualitative polymerase chain reaction (RT-qPCR). Out of nine subfraction extracts (SF1 to SF9), SF2 extract strongly inhibited MCF7 cells with the lowest IC50 value (23.51 ± 0.99 µg/mL) and substantially induced apoptosis in the MCF7 cells. SF2 extract significantly downregulated BCL-2 expression and upregulated P53, BAX, BID, BCL-2, caspase-8, caspase-9 and caspase-3 expressions in treated MCF7 cells. Therefore, SF2 extract was analysed using liquid chromatography coupled to quadrupole time–of–flight mass spectrometry (LC-QTOF-MS), which confirmed the presence of bioactive chemical compounds. Thus, it can be concluded that the compounds found in SF2 extract may potentially cause apoptosis in MCF7 cells through intrinsic and extrinsic pathways.
Molecular Docking Studies of Natural Immunomodulators Indicate Their Interactions With CD40 and CSF1 of Microglia
Authors: Maurya Shashank Kumar , Mishra Rajnikant 
Published: January 2022

Abstract
Natural products have proved beneficial in reducing neuroinflammation in neurological diseases. Their impacts have also been associated with the activities of microglia, responsible for brain-specific immunity. Recent studies have shown involvement of the number of microglia-specific proteins in the regulation of brain-specific immunity. However, molecular targets of natural products and their mechanisms of interactions with microglia-specific proteins are elusive. Since the genetic signature of microglia offers many potential targets for drug discovery, molecular docking followed by Molecular Dynamics (MD) simulations of Cluster of Differentiation 40 (CD40) and Colony-stimulating factor 1 receptor (CSF1R) proteins with some known neuro-immunomodulators (Curcumin, Cannabidiol, Ginsenosides, Resveratrol, and Sulforaphane) has been evaluated. Curcumin and Cannabidiol were observed likely to modulate CD40L and expression of cytokines and entry of inflammatory cells. Resveratrol and Cannabidiol may affect CSF1R and activation of microglia. Our finding suggests that Curcumin, Cannabidiol, and Resveratrol may serve specific drug ligands in regulating microglia-mediated brain immunity.
Estimation of Holocene bedload sedimentation rate in a paleo-drowned river-valley (Middle Harbour, Sydney estuary, Australia)
Authors: Lound Stephen P , Birch Gavin F , Dragovich Deirdre 
Published: January 2022

Abstract
Middle Harbour is a drowned-river valley located adjacent to the larger Sydney estuary, Australia. Extensive, high-resolution seismic data were correlated with borehole, land use, topographical, and geological data to calculate the mass of genetically different sediment deposits in Middle Harbour. The Harbour follows a well-defined drowned river-valley structure featuring small fluvial bedload delta deposits in the upper reaches of the embayments, a deep, central extensive mud basin overlying transgressive basal accumulations and a large flood-tide delta at the entrance. Deposits of an estimated 5,094 t of bedload, 21,143 t of suspended sediment and 5,947 t of transgressive basal material located in the estuary provided sedimentation rates of 0.68 t y-1, 1.29 t y-1, and 2.86 t y -1 respectively. These rates, determined from measured accumulations, were surprisingly low and substantially smaller than modelled rates. However, low sedimentation rates for suspended material may be due to fine sediment escaping over the top of the marine tidal delta, which effectively traps all bedload material from exiting the Harbour. Results of this study indicate that Holocene bedload sedimentation in Middle Harbour was slow and regular until a rapid increase after urbanisation commenced in the catchment. Most pre-Holocene material was eroded from Middle Harbour during the Last Glacial period with sediment currently present in the estuary having been deposited since sea-level recovery.