bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective interventions for the screening, brief intervention, referral and treatment of harmful alcohol use: an umbrella review protocol
Authors: Botwright Siobhan , Sutawong Jiratorn , Anothaisintawee Thunyarat , Kingkaew Pritaporn , Teerawattananon Yot , Khampang Roongnapa , Dabak Saudamini Vishwanath , Isaranuwatchai Wanrudee 
Published: June 2022

Abstract
Background Alcohol use is one of the leading risk factors for premature death and disability. Screening, brief interventions and referral to treatment, as well as evidence-based psychosocial and pharmacological interventions, are important in reducing the burden of harmful alcohol use. While many reviews summarise evidence for specific interventions or populations, there has yet to be a comprehensive comparison of interventions. As such, this umbrella review aims to identify effective interventions for the prevention and treatment of harmful alcohol use, with consideration of applicability to low- and middle-income country contexts.Methods A comprehensive search of MEDLINE via PubMed, Embase, Cochrane Database of Systematic Reviews, PsycINFO and the International HTA Database will be conducted from inception to September 2021. Selected articles will be systematic reviews of randomised controlled trials of interventions for screening, brief intervention, referral to treatment, or treatment of harmful alcohol use. Title/abstract screening, full-text screening, data extraction, and methodological quality assessment will be conducted by reviewers working independently and in duplicate, with conflicts resolved by a third reviewer. Data extraction will be conducted using a modified version of the Joanna Briggs Institute form, incorporating elements of the Template for Intervention Description and Replication (TIDieR) checklist, and quality assessment will be conducted using A MeaSurement Tool to Assess systematic Reviews (AMSTAR) 2. Findings will be summarised qualitatively in text and tables, with a focus on summarising important considerations for policymakers and identifying gaps in the literature.Discussion Results from this study will be disseminated through publication in a peer-reviewed journal and through presentation to policymakers in Thailand.Systematic review registration This protocol is registered in PROSPERO, CRD42021275471.
Serum potassium trajectory during AKI and mortality risk
Authors: Chávez-Íñiguez Jonathan S. , Maggiani-Aguilera Pablo , de Quevedo Andrés Aranda-García , Granado Rolando Claure-Del , Vega-Vega Olynka , López-Giacoman Salvador R. , Chávez-Alonso Gael , Oliva-Martínez Ana E. , Díaz-Villavicencio Bladimir , Calderón-García Clementina E. , González-Barajas David , Arizaga-Nápoles Manuel , Vega-Méndez Frida M. De la , Navarro-Blackaller Guillermo , Medina-González Ramón , Ibarra-Hernández Margarita , García-García Guillermo 
Published: June 2022

Abstract
Background: Kidneys play a primary role in potassium homeostasis. The association between potassium (sK+) level and mortality or the need for kidney replacement therapy (KRT) during acute kidney injury (AKI) has not been adequately explored. Methods: In this prospective cohort study, AKI patients admitted to the Hospital Civil de Guadalajara were enrolled from August 2017 to June 2021 with AKI. We divided patients into 8 groups based on the serum potassium level trajectories up to ten days following hospitalization, (1) normokalemia (normoK), defined as sK+ values between 3.5 and 5.5 mEq/L; (2) corrected hyperkalemia (hyperK), sK+ > 5.5 mEq/L on hospital admission and decreased to normoK; (3) corrected hypokalemia (hypoK), sK+ < 3.5 mEq/L on hospital admission and increased to normoK; (4) fluctuating potassium, sK+ increased / decreased in and out of normoK parameters; (5) uncorrected hypoK, sK+ < 3.5 mEq/L; (6) normoK to hypoK, sK+ that were normal on hospital admission and decreased to hypoK and never went back to normal; (7) normoK to hyperK, sK+ that were normal on hospital admission and increased to hyperK and never went back to normal; (8) uncorrected hyperK, sK+ > 5.5 mEq/L. We assessed the association of serum potassium trajectories with mortality and the need for KRT (secondary objective). Results: A total of 311 AKI patients were included. The mean age was 52.6 years, and 182 (58.6%) were male. AKI stage 3 was present in 199 (63.9%). KRT started in 112 (36%) patients, and 66 (21.2%) died. After adjusting for confounders, 10-day hospital mortality was significantly higher in group 7 and 8 (OR, 1.37 and 1.63, p = <0.05, for both, respectevely), and KRT initiation was higher only in group 8 (OR 1.40, p = < 0.05) compared with group 1. Mortality in different subgroups of patients in group 8 did not change the primary results.Conclusion: In our prospective cohort, most patients with AKI had alterations in sK+. NormoK to hyperK and Uncorrected hyperK were associated with death, while only uncorrected hyperK was correlated with the need for KRT.
Stable isotope characteristics of precipitation in Malaysia: Establishment of local meteoric water line
Authors: Mostapa Roslanzairi , Samuding Kamarudin 
Published: June 2022

Abstract

This paper discussed the use of stable isotope compositions of precipitation (d2H and d18O) to understand its characteristics and the parameters controlling meteorological conditions in Malaysia. The meteoric water line for Malaysia, or MMWL established in this study are d2H= (7.43±0.05)d18O + (7.33±0.11) (n=595, r2=0.97) for individual values, and d2H= (7.07±0.20)d18O + (4.90±0.75) (n=51, r2=0.96) for annual precipitation weighted means. No major variations in local meteoric water lines established between the stations, except for one (i.e., Cameron Highlands), which was found to be significantly different due to its high deuterium excess, or d value, attributed to moisture recycling (re–evapotranspiration) from the surrounding dense rainforest area. The precipitation moisture came from the two monsoon systems; the Northeast monsoon (NEM) and Southwest monsoon (SWM). They differ only slightly in their isotope signatures, where the NEM (winter monsoon) is 0.38‰ more negative than the SWM (summer monsoon), and the rainfall amount and temperature have a relatively weak influence on the stable isotopes in precipitation. Rainfall d18O is poorly correlated with the monthly rainfall amount and temperature, with very low r2 values (–0.4‰/100mm; 0.09 and 0.7‰/°C; 0.06, respectively). The seasonal variability of isotopic compositions of precipitation in this region is controlled by the insubstantial but conspicuous inverse correlation amount effect. The seasonal patterns of d2H and d18O are evident, with higher values observed during the NEM and lower values observed during SWM. However, the temporal variations of rainfall d2H and d18O during NEM and SWM are almost indistinguishable due to local climatic conditions, prevailing atmospheric circulations, and sources of precipitation. The apparent sign of El Niño and La Niña events (2015 and 2017, respectively) of the El Niño–Southern Oscillation (ENSO) cycle were successfully identified from this study, indicated by the heavier d18O from the peaks in the annual precipitation amount versus d18O annual precipitation weighted mean plot, while La Niña corresponds to the lighter values of the rainfall isotopes.
Neurophysiological Examination in Patients With Suspected Polyneuropathy Associated With Sars-CoV-2 Infection
Authors: Moure Jorge de Francisco , Ramón Irene Torres , Rodríguez Berenice Abreu , Navarro Sonia Navarrete , Lafita Carmen Almárcegui 
Published: June 2022

Abstract
Introduction:Neurological symptoms are common in patients who have suffered a SARS-CoV-2 infection. Cases of Guillain-Barré syndrome as well as sensory symptoms have been published in the context of a long COVID-19 syndrome.Patients and methods:We present 23 patients studied in a Clinical Neurophysiology department. All of them underwent a study of motor and sensory nerve conduction and of the F wave. In those patients with suspected fine fiber pathology, a study of the sympathetic-cutaneous response (SSR) was also performed.Results:In 8 patients alterations were observed in the neurophysiological study (NPS): 2 patients had a delay in the minimum latency of the F wave, 3 patients a decrease in its persistence, 2 patients an absence of SSR and 1 patient a decrease in the amplitude of the sensory action potentials.Patients with alterations in the NPS had a delay between SARS-CoV-2 infection and the appearance of neurological symptoms (median 16 days). Four of them had a self-limiting course and three others developed a long COVID-19 syndrome.In patients with normal NPS, sensory symptoms began at the same time as COVID-19 symptoms. All of them developed a long COVID-19 syndrome.Conclusion:Among these patients we find two profiles: in those with a pathological NPS there is a time delay between SARS-CoV-2 infection and neurological symptoms, often developing self-limiting symptoms. On the other hand, patients with a normal NPS start the neurological symptoms at the same time as the respiratory infection and all of them develop a long COVID-19 syndrome.
Comparison of granisetron and palonosetron in triplet anti-emetic prophylaxis in non-small cell lung cancer patients receiving cisplatin-based highly emetogenic chemotherapy
Authors: Araz Murat , Beypinar Ismail , Inci Fatih , Koral Lokman , Kocak Mehmet Zahid , Korkmaz Mustafa , Demirkiran Aykut , Eryilmaz Melek Karakurt , Artac Mehmet 
Published: June 2022

Abstract
Purpose
We compared the efficacy of first-generation granisetron and second-generation palonosetron in triplet anti-emetic prophylaxis in patients with non-small cell lung cancer (NSLC) receiving cisplatin-based high emetogenic chemotherapy (HEC).
Methods
This prospective, multicenter, non-randomized, observational study was conducted between June 2018 and December 2021. Patients diagnosed with NSCLC who received triplet anti-emetic prophylactic treatment with aprepitant and dexamethasone plus granisetron or palonosetron before the first cycle of chemotherapy were included in the study. At the end of the first week after chemotherapy, the emesis scale was applied to the patients during the outpatient control. The primary endpoint was complete response (CR) and total control (TC).
Results
One hundred twenty-one patients were included in the study. Sixty-one patients were in the granisetron group and 60 patients were in the palonosetron group. CR was higher with granisetron in the acute phase (70.5% vs. 58.3%, p = 0.16; respectively) and higher with palonosetron in the delayed phase (61.7% vs. 55.7%, p = 0.5; respectively), although not statistically significant. The TC rates were also not significantly different between the groups (54.1% vs.57.6%, p = 0.69).
Conclusion
There was no significant difference between granisetron and palonosetron in both acute and delayed control of emesis in NSCLC patients receiving cisplatin-based HEC.
TEAD is required for DNA repair independent of its transcriptional function
Authors: Calses Philamer C. , Pham Victoria C. , Verschueren Erik , Bakker Sietske T. , Haley Benjamin , Liu Chad , Chang Matthew T. , Kljavin Noelyn , Hinkle Trent , Zou Jianing , Yan Cuicui , Song Xia , Lin Xiaoyan , Rowntree Rebecca , Ashworth Alan , Lill Jennie R. , Dey Anwesha 
Published: June 2022

Abstract
The TEA domain family members 1-4 (TEADs) are major transcription factors for YAP/TAZ transcription activators in the Hippo pathway, regulating many biological processes, including development, tissue homeostasis, and tumorigenesis through target genes. Their amplification/upregulation correlates with poor prognosis in cancer patients. Although the Hippo pathway continues to be elucidated, it is clear that TEAD largely exerts its actions via transcriptional regulation. Here, we uncover an unexpected role for TEADs in the DNA damage response. Using comparative mass spectrometry, we demonstrate that TEADs interact with several DNA repair proteins. We further show that TEADs form DNA damage-induced nuclear foci that co-localize with DNA damage markers, γH2AX, and RIF1. We also found that TEADs are required for resistance to DNA damage, maintaining genome stability, and resolution of double strand break repair that is independent from the Hippo pathway and its transcriptional role. Our results establish a new role for TEADs in DNA repair and therefore, highlight a critical consideration in therapeutically targeting the Hippo pathway.
Deciphering the Roles of CircRNAs on Hepatic Metastases in Early Tumor Stage Colorectal Cancer Patients
Authors: Huang Maosen , Cheng Linyao , Ru Haiming , Wei Chunyin , Mo Xianwei , Yan Linhai 
Published: June 2022

Abstract
Objective
Circular RNAs (circRNAs), a specific type of non-coding RNAs, could regulate tumorigenesis and metastasis of various cancers though acting as competing endogenous RNA (ceRNAs).
Methods
Performing next generation sequencing (NGS) and bioinformatics methods, the profiles and the intricate roles of circRNAs were clarified in early stage colorectal cancer patients with hepatic metastases.
Results
CircRNAs were predicted to be involved in CRC hepatic metastasis complex processes, such as p53 binding and ErbB excision repair. Intriguingly, we detected 19 significantly differentially expressed among CRC patients with or without hepatic metastases and found circFARSA was significantly upregulated. Besides, circFARSA was found to be potential ceRNAs and a triple regulatory network of circFARSA/hsa-miR-503-5p/CCND2 was set up, which describes the possible mechanisms of CRC hepatic metastasis.
Conclusions
Our findings demonstrated that circFARSA acts as a promising biomarker in metastatic colorectal cancer (mCRC). The study provided a new perspective for targeting circFARSA in mCRC therapeutic treatment.
Geostatistical analysis of the integration of spatial information on nitrate-N observations and surface land uses for identifying groundwater pollution zones
Authors: Jang Cheng-Shin , Chen Shih-Kai , Lee Yuan-Yu 
Published: June 2022

Abstract
Groundwater nitrate-N pollution mainly originates from surface agricultural activities. Integrating spatial information on nitrate-N observations and agricultural land-use data is crucial for identifying groundwater pollution zones. This study used regression kriging (RK) to determine groundwater pollution zones in the Choushui River alluvial fan in Taiwan according to nitrate-N observations and agricultural land uses. Areal ratios of agricultural land-use types within buffering zones were first characterized using geographical information systems. A multivariate linear regression (MLR) model was employed to explore the relationship between groundwater nitrate-N pollution and agricultural land-use types. Then, simple kriging (SK) was adopted to analyze residuals obtained from gaps between nitrate-N observations and MLR predictions; the SK estimates of the residuals with the addition of the MLR predictions served as the RK estimates for groundwater nitrate-N pollution. Finally, groundwater pollution zones were determined according to a specific anthropogenic nitrate-N pollution level. The study results revealed that the “orchard” land-use type positively contributed to groundwater nitrate-N in contract to the “livestock house” and “agricultural facility” land-use types, which were negatively related to groundwater nitrate-N. Moreover, the RK estimates had the ability to characterize the potential pollution source of the orchard land-use type and were suitable for identifying groundwater pollution zones. Therefore, the amount of fertilizer used in the orchards located in groundwater pollution zones must be reduced considerably.
Antimicrobial Evaluation of Sequentially extracted Leaf of Vernonia auriculifera Hiern (Rejicho)
Authors: Etiso Teshale , Suleman Sultan , Mohamed Tesfaye 
Published: June 2022

Abstract
Background: Though there are reports about V. auriculifera antimicrobial activity, there is not enough information about its activity on some of the bacterial and fungal species. Besides, there was no quantitative evaluation done for phytochemicals previously. Therefore, the main purpose of this research work is to evaluate the antimicrobial activity and quantitative evaluation of the phenol and flavonoid contents of V. auriculifera. Objectives: The objective of this study was to conduct the antimicrobial and quantitative evaluation of a sequentially extracted leaf of Vernonia auriculifera Hiern. Methods: The leaves of the plant were cleaned with tap water and air-dried. The grounded leaf product was subsequently extracted by hexane, chloroform, and methanol in maceration flasks. Then the total phenol and total flavonoid content in each extract were determined. Standard strains of bacterial and fungal species were used to assess the antibacterial, antifungal susceptibility test and to determine the minimum inhibitory concentration of crude extract. Result: Extraction yield for hexane, chloroform, and methanol was 0.6±0.05%, 1.7±0.02%, and 3.3±0.01% respectively. The total phenolic content of methanol extract was 72.998 ± 0.002 mg GAE /g. The total flavonoid content of hexane and chloroform extracts were 2.59 ± 0.004 mg QE/g and 9.6 ± 0.02 mg QE/g respectively. The antimicrobial activity test showed the chloroform extract was the most active against all test microorganisms. Conclusion: This study has shown the activity of V. auriculifera against selected microorganisms of study. The chloroform extract was the most active as compared to the hexane and methanol extracts.
Association of proton pump inhibitors with renal adverse events in non-small cell lung cancer patients treated with PD-1 Inhibitor (APPIANI Study): study protocol for a randomized, assessor- blinded, controlled clinical trial
Authors: Mu Xiaodie , Wu Aihua , Ling Peiyao , Zhou Hua , Yang Min 
Published: June 2022

Abstract
Introduction: PD-1 inhibitor, an immune checkpoint inhibitor (ICI), is currently the standard first-line treatment for advanced non-small cell lung cancer (NSCLC). Immune-related adverse effects (irAEs), on the other hand, limit their use. Acid-suppressive drugs (ASDs), including proton pump inhibitors (PPIs) and histamine 2 receptor antagonist (H2RA), are well known as common concomitant drugs in the treatment of cancer. When coupled with ICIs, however, PPIs may increase the incidence of renal adverse events (AEs). The objective of this paper is seeing how commonly individuals with NSCLC developed acute kidney disease and renal dysfunction (AKD) after receiving PD-1 inhibitors and PPIs combined. Methods: This study is a randomized, assessor- blinded, controlled clinical trial. Participants who are diagnosed with NSCLC, and taking PPIs or H2RA are randomly assigned to the intervention (using PPIs) and control (using H2RA) groups for 12 weeks in a ratio of 1: 1, and will be followed up for another 12 weeks after treatment. The primary outcome is to explore whether there is a difference in the occurrence of renal AEs between patients with NSCLC treated with PPIs and those without PPIs. Discussion: Our findings will have significant implications for AKD prevention and control in the PD-1 inhibitor-treated patients with NSCLC. In addition, it may be valuable to improve policy development and PPIs clinical practice guidelines across China. Trial registration: ClinicalTrials.gov ChiCTR2200057366. Registered on March 9, 2022
A promising animal model for Polycystic Ovary Syndrome: Borderline Hypertensive Rats
Authors: Zhang Ting , Xu Jinfeng , Maung Ei Ni Tar , Chen Le , Wang Li 
Published: June 2022

Abstract
Background: Borderline Hypertensive Rat (BHR) is the offspring of female spontaneously hypertensive rats (SHR) and male Wistar-Kyoto (WKY) rats, that were used in studies of hypertension and cardiovascular disease. We found that the fertility rate of BHR decreased and the pregnancy rate was 60% (15/25) when BHR was prepared as a pregnant animal model of preeclampsia. We found that there was no study on the reproductive system of female BHR. The purpose of this study was to explore the reproductive phenotype of female BHR. The vaginal smears were performed to detect and evaluate the phases of the estrous cycle. According to the estrous cycle, BHR were divided into two groups: normal group and polycystic ovary syndrome (PCOS) group. The HE staining was used to observed the morphology of ovary and uterus, and serum sex hormone concentrations were measured. Result: The results showed that there were 46 female BHR, 21 of them (45.7%) were found with PCOS. In PCOS group, the weight of ovary was increased, the estrous cycle was irregular, the cell layer of cystic follicles membrane was thickened, the endometrium was thickened, and the levels of serum testosterone, estrogen , luteinizing hormone (LH), LH / FSH (Follicle Stimulating Hormone) were increased. Polycystic ovaries were found in female BHR with PCOS. And the estrous cycle and sex hormone level of female BHR with PCOS were consistent with the characteristics of PCOS. Conclusions: PCOS occurred in some female BHR, the pathophysiological changes were including the estrous cycle, the morphology of ovary and uterus , and the sex hormone levels.
The Effects of Cognitive Training in the Long Term: a Systematic Review of the Literature
Authors: Druda Ylenia , Chattat Rabih , Chirico Ilaria , Casapulla Rita , Pappadà Alessandro , Esposti Valentina Degli , Ottoboni Giovanni 
Published: June 2022

Abstract
OBJECTIVE: In this literature review, long term cognitive training’s effect is assessed. The issue is investigated by also considering additional training sessions (also called booster sessions) and their impact on the retention of after-training benefits. The aim is achieved by analyzing four variables: involved population, training domains, effect transferability, and training duration.METHODS: In compliance with the PRISMA statement, a search was conducted in the following database: Scopus, PubMed, WoS, and CINAHL.RESULTS: Out of the 1063 articles we identified initially, 47 studies were eligible.The studies showed that training can maintain cognitive functioning in healthy people or people with MCI, especially for what concerns the six months after the intervention. In people with dementia, the results were controversial. Regarding the booster training sessions, when they were offered to either healthy people or people with MCI, they both maintained or increased training benefits. In contrast, people with dementia appeared to benefit from booster sessions in one study only. It also emerged that single and multi-domain training improved cognitive functioning in either healthy people or people with MCI. In contrast, only multi-domain training was effective in people with dementia. Cognitive training showed both direct and far transfer effects. CONCLUSIONS: Although cognitive training benefits appear to persist, especially when working with healthy people or people with MCI, future studies should focus more on the benefits carried by booster sessions. Moreover, once the analysis of these outcomes is cross-referenced with individual characteristics and preferences, it will specify the long-term benefits factors.