bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery of Quercetin and Its Analogs as Potent OXA-48 Beta-Lactamase Inhibitors
Authors: Zhang Yuejuan , Chen Cheng , Cheng Bin , Gao Lei , Qin Chuan , Zhang Lixia , Zhang Xu , Wang Jun , Wan Yi 
Published: June 2022

Carbapenem resistance in Enterobacteriaceae caused by OXA-48 β-lactamase is a growing global health threat and has rapidly spread in many regions of the world. Developing inhibitors is a promising way to overcome antibiotic resistance. However, there are few options for problematic OXA-48. Here we identified quercetin, fisetin, luteolin, 3′,4′,7-trihydroxyflavone, apigenin, kaempferol, and taxifolin as potent inhibitors of OXA-48 with IC50 values ranging from 0.47 to 4.54 μM. Notably, the structure-activity relationship revealed that the substitute hydroxyl groups in the A and B rings of quercetin and its structural analogs improved the inhibitory effect against OXA-48. Mechanism studies including enzymatic kinetic assay, isothermal titration calorimetry (ITC), and surface plasmon resonance (SPR) analysis demonstrated that quercetin reversibly inhibited OXA-48 through a noncompetitive mode. Molecular docking suggested that hydroxyl groups at the 3′, 4′ and 7 positions in flavonoids formed hydrogen-bonding interactions with the side chains of Thr209, Ala194, and Gln193 in OXA-48. Quercetin, fisetin, luteolin, and 3′,4′,7-trihydroxyflavone effectively restored the antibacterial efficacy of piperacillin or imipenem against E. coli producing OXA-48, resulting in 2–8-fold reduction in MIC. Moreover, quercetin combined with piperacillin showed antimicrobial efficacy in mice infection model. These studies provide potential lead compounds for the development of β-lactamase inhibitors and in combination with β-lactams to combat OXA-48 producing pathogen.
Measurement of Lexical Diversity in Children’s Spoken Language: Computational and Conceptual Considerations
Authors: Yang Ji Seung , Rosvold Carly , Bernstein Ratner Nan 
Published: June 2022

BackgroundType-Token Ratio (TTR), given its relatively simple hand computation, is one of the few LSA measures calculated by clinicians in everyday practice. However, it has significant well-documented shortcomings; these include instability as a function of sample size, and absence of clear developmental profiles over early childhood. A variety of alternative measures of lexical diversity have been proposed; some, such as Number of Different Words/100 (NDW) can also be computed by hand. However, others, such as Vocabulary Diversity (VocD) and the Moving Average Type Token Ratio (MATTR) rely on complex resampling algorithms that cannot be conducted by hand. To date, no large-scale study of all four measures has evaluated how well any capture typical developmental trends over early childhood, or whether any reliably distinguish typical from atypical profiles of expressive child language ability.Materials and MethodsWe conducted linear and non-linear regression analyses for TTR, NDW, VocD, and MATTR scores for samples taken from 946 corpora from typically developing preschool children (ages 2–6 years), engaged in adult-child toy play, from the Child Language Data Exchange System (CHILDES). These were contrasted with 504 samples from children known to have delayed expressive language skills (total n = 1,454 samples). We also conducted a separate sub-analysis which examined possible contextual effects of sampling environment on lexical diversity.ResultsOnly VocD showed significantly different mean scores between the typically -developing children and delayed developing children group. Using TTR would actually misdiagnose typical children and miss children with known language impairment. However, computation of VocD as a function of toy interactions was significant and emerges as a further caution in use of lexical diversity as a valid proxy index of children’s expressive vocabulary skill.DiscussionThis large scale statistical comparison of computer-implemented algorithms for expressive lexical profiles in young children with traditional, hand-calculated measures showed that only VocD met criteria for evidence-based use in LSA. However, VocD was impacted by sample elicitation context, suggesting that non-linguistic factors, such as engagement with elicitation props, contaminate estimates of spoken lexical skill in young children. Implications and suggested directions are discussed.
Development and Validation of a Language Screening for Implementation in Pre-School Settings
Authors: Holzinger Daniel , Weber Christoph , Diendorfer Bettina 
Published: June 2022

BackgroundTo prevent or mitigate long-lasting learning problems and emotional, behavioral, and social-adaption difficulties associated with language disorders, age-appropriate German language competence at school entry level is essential. Therefore, universal screening of children in their penultimate year of pre-school has been established in Upper Austria. So far, the screenings administered by speech and language pathologists to identify risk of language disorder (LD) were not based on standardized materials.ObjectiveTo develop a screening instrument to identify increased risk of LD and to evaluate its validity and feasibility within the constraints of regular universal pre-school language screening.DesignA two-component screening instrument including direct assessment of expressive and receptive grammar was used in a sample of 374 children with German as their dominant language attending a public pre-school in their penultimate year (age 4-5 ½ years) in the state of Upper Austria. Assessment by use of standardized German language tests including a variety of linguistic domains was considered reference standard for diagnosing LD. Feasibility was assessed by a self-developed questionnaire completed by the administrators of the screening.ResultsThe combination of the expressive and receptive grammar scales demonstrated excellent accuracy (area under the curve score 0.928). A cut-off of 18 resulted in a failing rate of 21.8% and showed good sensitivity (84.2%) and specificity (85.3%). Acceptance by children and testers, time-economy and sustainability of the screening were mostly rated as high.
Analisis Terhadap PenegakAnalisis Penegakan Hukum Pemilu Dalam Perspektif UU No 7 Tahun 2017
Authors: Octavia Vanessa vanessa 
Published: June 2022

Abstract
The title of this is article is "Analysis of Election Law Enforcement in the Perspective of Law No. 7 of 2017" The main problem we raised is how the KPU faces changes to Law No. 15 of 2011 concerning election administrators and Law Number 8 of 2012 concerning the election of DPR, DPD and DPRD Members into Law Number 7 of 2017 and what are the challenges faced by KPU in the Implementation of Laws Number 7 of 2017. In this paper the method we used is quantitative analysis that gives an overview of an object through certain analytical techniques. The ways that can be done by the KPU in dealing with changes to Law Number 15 Year 2011 concerning election administrators and Law Number 8 of 2012 concerning the election of DPR, DPD and DPRD Members become Law Number 7 Year 2017. Something that can be made are involving electoral institutions, which in this case is the Bawaslu (Election Supervisory Body) and its ranks. Therefore, Bawaslu must increase strict supervision in the administration of elections.
Keywords: how to deal with changing laws, challenges faced by the KPU, Law Number 7 of 2017
عروض مختصرة
Authors: الحوامدة إيصال صالح 
Published: June 2022

من النبي ﷺ إلى البخاري دراسة في حركة رواية الحديث ونقده في القرون الثلاثة الأولى، أحمد عبد الجبار صنوبر، عمّان: دار الفتح للدراسات والنشر، ط1، 2022م، 448 صفحة.
تحليل الخطاب القرآني- دراسة نقدية تطبيقية للمناهج الغربية المعاصرة، حمازة محمد الطاهر، إربد- الأردن: دار ركاز للنشر والتوزيع، ط1، 2021م، 615 صفحة.
الغزالي وفلسفته الكلامية، فرانك غريفل، ترجمة: مريم شحاتة، بيروت: دار الروافد الثقافية، ط1، 2021م، 640 صفحة.
النهضة في القرآن الكريم بناؤها ومقوماتها من خلال سورة الكهف، علي محمد أسمر، عمّان: جمعية المحافظة على القرآن الكريم، ط1، 2018م، 346 صفحة.
العمارة والسياسة والتاريخ - المدينة الإسلامية في مغرب العصر الوسيط، مصطفى عرباوي، إربد-الأردن: عالم الكتب الحديث، ط1، 2020م، 330 صفحة.
العمران فلسفة الحياة في الحضارة الإسلامية، خالد عزب، القاهرة: الدار المصرية اللبنانية، ط1، 2022م، 280 صفحة.
علاقة الفكر الإصلاحي بمقاصد العقيدة ومقاصد الشريعة: محمد الطاهر ابن عاشور أنموذجاً، عثمان كضوار، عمّان: دار ركاز للنشر والتوزيع، ط1، 2021م، 395 صفحة.
طرق معرفة مقاصد الشريعة وضوابط إعمالها في النظر الاجتهادي، محمد المنتار، بيروت: الرابطة المحمدية للعلماء، ط1، 2020م، 412 صفحة.
تعدد المرجعية في ضوء مقاصد الشريعة الإسلامية، نور الدين الخادمي، لندن: مؤسسة الفرقان للتراث الإسلامي، ط1، 2020م، 452 صفحة.
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مقاصد الشريعة من التدوين إلى التقعيد، أبو القاسم بن أحمد إبراهيم مسملي، الدمام: دار ابن الجوزي، ط1، 2022م، 440 صفحة.
الدليل النقلي في الفكر الكلامي، أحمد عبد الرحيم، الرياض: مركز تكوين للدراسات والأبحاث، 2019م، 504 صفحة.
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رؤية العالم حضور وممارسات في الفكر والعلم والتعليم، فتحي حسن ملكاوي، فرجينيا-واشنطن: المعهد العالمي للفكر الإسلامي، 2021م، 448 صفحة.
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Islamic Theology in the Turkish Republic (Edinburgh Studies on Modern Turkey) 1st Edition, by Philip Dorroll, Edinburgh: Edinburgh University Press, April 2021, 248
Shaping a Qur'anic Worldview: Scriptural Hermeneutics and the Rhetoric of Moral Reform in the Caliphate of al-Ma'un (Routledge Studies in the Qur'an), by Vanessa De Gifis, London: Routledge, December 2019, 142 pages
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Aplikasi Pupuk Organik Cair dari Limbah Organik Perkotaan pada Tanaman Bawang Merah (Allium Ascalonicum L.)
Authors: Haryanta Dwi , Sa’adah Tatuk Tojibatus , Thohiron Moch. , Indarwati Indarwati , Permatasari Dian Fitri 
Published: June 2022

Limbah organik perkotaan jumlahnya semakin meningkat dapat menganggu kesehatan dan menyebabkan pencemaran lingkungan. Pemrosesan limbah organik sebagai pupuk organik dapat menjadi salah satu solusi permasalahan limbah. Penelitian bertujuan memanfaatkan pupuk organik cair dari limbah organik perkotaan untuk budidaya tanaman bawang merah. Penelitian dilaksanakan di laboratorium dan kebun percobaan Fakultas Pertanian Universitas Wijaya Kusuma Surabaya mulai bulan April 2020 sampai Agustus 2021. Percobaan faktorial dengan perlakuan faktor 1 adalah bahan baku pembuatan Pupuk Organik Cair (POC) yang terdiri dari 7 level yaitu P1 = POC campuran 6 bahan jenis limbah, P2 = POC dari limbah sayuran, P3 = POC dari limbah buah, P4 = POC dari limbah kecambah, P5 = POC dari limbah makanan, P6 = POC dari limbah ikan lele, dan P7 = POC dari limbah darah sapi. Perlakuan faktor 2 adalah konsentrasi larutan POC yang terdiri K1 = 4%, K2 = 8%, dan K3 = 12%. Percobaan dilaksanakan dengan rancangan acak kelompok. Hasil penelitian menunjukkan bahwa jenis bahan baku dan konsentrasi pupuk organik cair tidak berpengaruh nyata terhadap variabel pertumbuhan (panjang tanaman dan jumlah daun) serta hasil tanaman bawang merah (berat panen dan berat konsumsi). Jenis bahan baku pupuk organik cair berpengaruh nyata terhadap rendemen (berat kering konsumsi dibanding berat panen), yaitu pupuk organik cair dari limbah ikan, darah sapi dan campuran 6 bahan menunjukkan rendemen yang lebih tinggi dibandingkan dengan bahan baku sayuran, buah, kecambah dan limbah makanan (catering).
AI in 6G: Energy-Efficient Distributed Machine Learning for Multilayer Heterogeneous Networks
Authors: Hossain Mohammad Arif 
Published: June 2022

<p> Adept network management is key for supporting extremely heterogeneous applications with stringent quality of service (QoS) requirements; this is more so when envisioning the complex and ultra-dense 6G mobile heterogeneous network (HetNet). From both the environmental and economical perspectives, non-homogeneous QoS demands obstruct the minimization of the energy footprints and operational costs of the envisioned robust networks. As such, network intelligentization is expected to play an essential role in the realization of such sophisticated aims. The fusion of artificial intelligence (AI) and mobile networks will allow for the dynamic and automatic configuration of network functionalities. Machine learning (ML), one of the backbones of AI, will be instrumental in forecasting changes in network loads and resource utilization, estimating channel conditions, optimizing network slicing, and enhancing security and encryption. However, it is well known that ML tasks themselves incur massive computational burdens and energy costs. To overcome such obstacles, we propose a novel layer-based HetNet architecture which optimally distributes tasks associated with different ML approaches across network layers and entities; such a HetNet boasts multiple access schemes as well as device-to-device (D2D) communications to enhance energy efficiency via collaborative learning and communications. </p>
On Asymptotic Convergence Rate of Evolutionary Algorithms
Authors: Tarłowski Dawid 
Published: June 2022

<p>This paper presents theoretical studies on Asymptotic Convergence Rate (ACR) for finite dimensional optimization. Given the problem function (fitness function), ACR measures how fast an iterative optimization method converges to the global solution as the number of iterations increases to infinity. If less than one, it determines fast exponential convergence mode ( known as linear convergence in various contexts). The presented theory extends the previous studies on Average Convergence Rate, a related convergence rate measure. The main focus is on the question how the change of problem function may influence the value of ACR and what is the relation between convergence rate in the objective space and in the search space. It is shown, in particular, that the ACR is the maximum of two components, one of which does not depend on the problem function. This provides the lower bound for convergence rate and implies that some algorithms cannot converge exponentially fast for any nontrivial continuous optimization problem. Furthermore, among other results, it is shown how the convergence rate in the search space is related to the convergence rate in the objective space if the problem function is dominated by some polynomial. We discuss various examples and numerical simulations with use of (1+1) self-adaptive evolution strategy and other algorithms.</p>
Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors in Oncology Clinical Trials: A review
Authors: Feustel Kavanya , Falchook Gerald S. 
Published: June 2022

ABSTRACT
Protein arginine methyltransferase 5 (PRMT5) inhibitors are a new class of antineoplastic agents showing promising preliminary clinical efficacy. Targeting an enzyme involved in a wide array of cellular and transcriptional pro-oncogenic processes, this class offers multifaceted tumor-suppressive effects. Partial response has been seen in adenoid cystic carcinoma from both GSK3326595 and JNJ-64619178, with four cases of stable disease seen with PRT543. Highly significant is a durable complete response in isocitrate dehydrogenase 1-mutated glioblastoma multiforme with PRT811. Both alone and in combination with existing chemotherapies and immunotherapies, this class shows promising preliminary data, particularly in cancers with splicing mutations and DNA damage repair deficiencies. Further studies are warranted, and there are clinical trials to come whose data will be telling of the efficacy of PRMT5 inhibitors in both hematologic and solid malignancies. The aim of this study is to compile available results of PRMT5 inhibitors in oncology clinical trials.
Protein Kasar dan Lemak Kasar Amofer Tongkol Jagung Menggunakan M21 Dekomposer dan Urea pada Level yang Berbeda
Authors: Prasetyo Agus , Fitria Restuti , Hindratiningrum Novita 
Published: June 2022

Pemanfaatan limbah hasil pertanian berupa janggel jagung dalam rangka mengatasi permasalahan ketersediaan pakan ternak ruminansia. Pemanfaatan janggel jagung sebagai pakan masih sangat minim dikarenakan kandungan protein, dan kecernaan yang rendah serta kandungan lignin yang tinggi sehingga perlu dilakukan pengolahan terlebih dahulu. Salah satu metode pengolahan janggel jagung adalah menggunakan metode amoniasi fermentasi (amofer).
Tujuan penelitian ini untuk mengevaluasi penggunaan M21 dekomposer dan urea terhadap kandungan protein dan lemak kasar amoniasi fermentasi janggel jagung. Penelitian ini dilaksanakan menggunkan metode eksperimental dengan Rancangan Acak Lengkap (RAL). Perlakuan dalam penelitian ini adalah penambahan M21 dekomposer dan urea (0 ; 0,04:3 ; 0,06:3 ; 0,04:5 ; 0,06:5 dari total larutan formula). Variabel yang diamati adalah protein dan lemak kasar
Hasil penelitian menunjukan bahwa perlakuan M21 dekomposer dan urea berpengaruh sangat nyata (P < 0,01) terhadap peningkatan Protein Kasar yaitu pada perlakuan R4 (janggel jagung diamofer dengan penambahan M21 dekomposer 0,06% dan urea 5%) yaitu sebesar 6.19 ± 0,07 %. Serta dalam uji Lemak Kasar diperoleh hasil berpengaruh nyata (P < 0,05), dengan Kadar Lemak Kasar tertinggi diperoleh pada perlakuan R2 (janggel jagung diamofer dengan penambahan M21 dekomposer 0,06% dan urea 3%) yaitu sebesar 6.11 ± 0.09 dan terendah pada perlakuan R4 (janggel jagung diamofer dengan penambahan M21 dekomposer 0,06% dan urea 5%) yaitu sebesar 3.26 ± 0.04.
Kata Kunci: Amofer, Janggel Jagung, M21 Dekomposer
Efek Lama Proses Amofer terhadap Protein Kasar dan Lignin Kulit Buah Kakao
Authors: Ardigurnita Firgian , Frasiska Nurul , Rahayu Novia 
Published: June 2022

Indonesia merupakan produsen dan eksportir kakao terbesar ketiga di dunia setelah Ghana dan Pantai Gading. Produksi kakao di Indonesia tahun 2020 sebesar 720.660 ton. Kulit buah kakao memiliki potensi kandungan nutrisi yang cukup baik untuk ternak ruminansia yang meliputi bahan kering 17,2%; bahan organik 81,2%; protein kasar 9,07%; neutral detergent fiber (NDF) 73,9%; acid detergent fiber (ADF) 58,98%;selulosa 38,65%; dan lignin 20,15% Tujuan dari penelitian ini adalah mengetahui berapa waktu yang optimal dalam pembuatan pakan dari kulit buah kakao dengan proses amoniasi dan fermentasi (amofer). Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 5 perlakuan lama proses amoniasi fermentasi (Amofer) dengan 5 kali ulangan. Perlakuan penelitian yaitu : P0 = kulit buah kakao tanpa urea dan tanpa Aspergillus Niger, P1 = kulit buah kakao + urea 6% + Aspergillus Niger 0,31% + Mineral mix 2% selama 7 hari, P2 = kulit buah kakao + urea 6% + Aspergillus Niger 0,31% + Mineral mix 2% selama 14 hari, P3 = kulit buah kakao + urea 6% + Aspergillus Niger 0,31% + Mineral mix 2% selama 21 hari P4 = kulit buah kakao + urea 6% + Aspergillus Niger 0,31% + Mineral mix 2% selama 28 hari. Hasil penelitian menunjukkan kadar air kulit buah kakao yang diamoniasi pada hari ke-0 berbeda nyata (P<0.05) dengan kadar air hari ke-7, ke-14, ke-21 dan ke-28. Peubah yang diukur yaitu kandungan nutrisinya yang meliputi kadar air, kadar abu, protein kasar (PK) dan lignin total. Data yang diperoleh dianalisis menggunakan analisis variansi dan dilanjutkan uji orthogonal polinomial. Kadar abu pada hari ke-14, ke-21 dan ke-28 pada pembuatan kulit buah kakao dengan metode amoniasi fermentasi (amofer) menggunakan urea dan Aspergillus Niger yaitu (P<0.05) berbeda nyata dengan kontrol. Hasil analisis protein kasar pada hari ke-7, ke-14, ke-21 dan ke-28 pada pembuatan kulit buah kakao dengan metode amoniasi fermentasi (amofer) menggunakan urea dan Aspergillus Niger yaitu (P<0.05) berbeda nyata dengan kontrol. Hasil analisis lignin total pada hari ke-7, ke-14, ke-21 dan ke-28 pada pembuatan kulit buah kakao dengan metode amoniasi fermentasi (amofer) menggunakan urea dan Aspergillus Niger yaitu (P<0.05) berbeda nyata dengan kontrol. Kesimpulan perlakuan kulit buah kakao dengan amofer yaitu pemberian tambahan urea 6% + Aspergillus Niger 0,31% + Mineral mix 2% dengan perbedaan lama waktu perlakuan hingga 28 hari dapat meningkatkan protein kasar dan kadar air serta menurunkan kadar abu dan lignin total.
Kata kunci: amofer, amoniasi, fermentasi, kulit buah kakao, pakan.
Türkiye’de Sosyal Alanda Yaşanan Kültürel Mücadelelerde Dindarlaşma, Deizm ve Ateizm Süreçleri
Authors: BAĞCI İkram 
Published: June 2022

Bu çalışmada, Türkiye’de Adalet ve Kalkınma Partisi’nin iktidar olduğu sürede dindarlaşma, deizm ve ateizm süreçlerine yönelik gerçekleşen gelişmeler, Bourdieu Sosyolojisi’nin temel kavramları çerçevesince ele alınmış ve bu süreçte Türkiye’nin dindarlaştığı veya deistleştiğine yönelik bazı değerlendirmelerin ve medyada çıkan haberlerin aslen sosyal ve siyasal alanda farklı grupların kültürel iktidarı kazanmaya yönelik mücadele stratejileri olduğu belirtilmiştir. Bu mücadelelerin sonunda ise muhafazakâr ve seküler grupların Türkiye’de hem siyasal hem de sosyal alanda tek taraflı kültürel bir zafer kazanabileceklerine dair ortaya koymuş oldukları kültürel politikaların Türkiye’nin iç siyasetinde kutuplaşmaya neden olduğu ve bir tarafın galip geleceği bir zaferin yaşanamayacağı gerçeği belirtilmek istenmiştir. Çalışmada Cumhuriyet’in kuruluşu sonrasında yaşanan kültürel mücadelelerle, Ak Parti iktidarı sonrasındaki yaşanan gelişmelerin yanında deizm, dindarlaşma ve ateizm ile ilgilibilimsel çalışmalar, medyadaki haberler ve araştırma şirketlerinin verileri, döküman analizi ile bir araya getirilmiş ve betimsel analiz tekniği ile de karşılaştırılarak sürece yönelik değerlendirilmelerde bulunulmuştur.
Correlation of Malignancy in the Hepato-Pancreato-Biliary System with Serum Bilirubin Levels in Extrahepatic Cholestasis Patients
Authors: Tansa Rizqy , M. Iqbal Rivai  , Avit Suchitra  
Published: June 2022

Background: The incidence of hepato-pancreato-biliary system cancer is increasing worldwide, which has been recognized as a disease that is difficult to diagnose early and has a poor prognosis. No research has yet been conducted in areas with limited resources and health facilities. There is an urgent need for diagnostic methods to recommend further diagnostic modalities in the selection of curative or palliative management.
Methods: Retrospective data from all cholestatic patients at Dr. M. Djamil General Hospital were collected during the period July 2020-May 2022. The data included demographic characteristics such as age, gender, preoperative, results of bilirubin fraction, and final diagnosis. Data analysis was done by bivariate and multivariate.
Results: A total of 132 patients were included in this study. 35.6% of them are HPB system malignancies, with Pancreatic Adenocarcinoma being the most common diagnosis (34.4%), more in males (51.06%), and in the age group, 50 years (61.71%) is the most. Only 52.27% of patients underwent preoperative radiological imaging. Bivariate analysis showed a significant relationship between HPB system malignancies with age >50 years (p=0.024) and all bilirubin fractions (p<0.001). Multivariate analysis showed that only the bilirubin fraction was significant for the diagnosis of malignant HPB (p<0.001).
Conclusion: The bilirubin fraction is a good initial indicator for predicting malignancy in the HPB system in order to increase the effectiveness of the diagnostic modality and reduce the referral duration.