bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organically Surface Engineered Mesoporous Silica Nanoparticles Control the Release of Quercetin by pH Stimuli
Authors: Saputra Ozi Adi , Lestari Windy Ayu , Kurniasyah Viardi , Lestari Witri Wahyu , Sugiura Takashi , Mukti Rino Rakhmata , Martien Ronny , Wibowo Fajar Rakhman 
Published: July 2022

Abstract
Controlling the premature release of hydrophobic drugs like quercetin over physiological conditions remains a challenge that motivates the development of smart and responsive drug carriers in recent years. This present work designed and engineered the surface of mesoporous silica nanoparticles (MSNs) by a functional compound having both amines (as a positively charged group) and carboxylic (negatively charged group), namely 4-((2-aminoethyl)amino)-4-oxobut-2-enoic acid (AmEA) prepared via simple mechanochemistry approach. The physical, textural, and morphological of MSN and MSN-AmEA were characterized by TGA, N2 adsorption-desorption, PSA-zeta, SEM, and TEM. The impact of surface modification toward textural and morphological features caused a significant decrease of BET surface area from 1038.53 m2 g− 1 (MSN) to 858.41 m2 g− 1 (MSN-AmEA). Nevertheless, the colloidal stability of MSN-AmEA is greatly improved showing by high zeta-potential especially at pH 4 compared to MSN. the effective loading capacity of MSN-AmEA was better than MSN, about 118% in comparison. Also, in contrast to MSN, MSN-AmEA prevent quercetin release at pH 7 while it is easier release at pH 4, thanks to the presence of the functional groups that has pose sensitive interaction hence it may fully control the quercetin release, as elaborated by the DFT study. Therefore, the controlled release of quercetin over MSN-AmEA verified its capability of acting as a smart drug delivery system.
Establishment of metastasis-related prognostic models for colon cancer and bioinformatics analysis of the benefits of aspirin chemoprophylaxis
Authors: Li Jing , Shen Cheng , Jiang Xiaohui , Cui Xiaopeng , Wu Zhijun , Liu Yushan , Yang Yanguang , Zhang Siming , Huang Tianyi , Shen Aiguo 
Published: July 2022

Abstract
Background: Invasion and metastasis are the main factors affecting the prognosis of patients with colorectal cancer. Therefore, it is urgent to explore the key metastasis genes and potential regulatory mechanisms that affect the prognosis of colorectal cancer, and provide new prognostic markers or therapeutic targets for colorectal cancer.Methods: Firstly, we obtained differentially expressed metastasis-related genes in cancer and normal tissues. By constructing WGCNA from differentially expressed genes, the modules most associated with colon cancer were identified. Univariate and lasso-cox regression analyses were used to identify key prognostic genes for the most relevant modules and to establish a risk score model. Nomogram model was constructed to predict OS of colon cancer patients by risk score. GO and KEGG enrichment analysis were performed to study the pathways and functions of these module genes. Iregulon plugin in cytoscape was used to explore the transcription factors of module genes. Finally, aspirin interacting genes were obtained through the Comparative Toxicology Genomics Database, and the clinical significance of aspirin regulation on these genes was clarified.Results: 2062 metastasis-related genes were involved in the construction of WGCNA, blue and yellow modules were significantly correlated with colon cancer. Analysis of GO and KEGG pathways of these two modules showed that the function of differential genes is closely related to many important processes in tumor genesis and metastasis. We used the blue module gene to build a risk score model that predicted overall survival (OS). In addition, nomogram combining risk score with age, stage, and M-stage were developed to better predict 1-, 3-, and 5-year survival. Transcription factor analysis showed that E2F family were the key regulator of blue module, while NFκB1 and STAT3 were the key transcription factors of yellow module. Finally, we identified that patients of colon cancer whose NOX4, CXCL8, CXCL5, GDF15, and MMP13 genes were continuously upregulated may not be suitable for aspirin chemoprophylaxis.Conclusions: We developed and validated a predictive model of metastasis genes. Patients with colon cancer whose NOX4, CXCL8, CXCL5, GDF15, and MMP13 genes are upregulated may not be ideal candidates for aspirin chemoprophylaxis.
Spectrum and frequency of food allergy in Kyiv`s adult citizens with allergic rhinitis: a cross-sectional study
Authors: Tsaryk Vladyslav , Neverovskyi Artem , Kurchenko Andrii 
Published: July 2022

Abstract
Background: Food allergy affects 1-3% of adults worldwide. More than 160 foods can cause allergic reactions. Food allergy may preceed and stimulate allergic rhinitis. Aim of the study was to assess the spectrum and frequency of sensitization to food allergens in patients with established allergic rhinitis from Kyiv, Ukraine.Methods. The investigation was conducted as a cross-sectional study. 175 Kyiv adult patients with allergic rhinitis were enrolled to the trial. Sensitization to allergens and their components was determined by skin prick tests and in vitro detection of allergen specific IgE by ELISA in serum of the blood – multicomponent Allergy Explorer2- ALEX2 test.Results. It was shown, that sensitization to following inhalant allergens was predominant: to timothy grass – in 50,3%, to ragweed - in 48,6%, to birch – in 44%, to wormwood – in 24%, to Alternaria alternatus mold – in 15,4% of patients. 131 (74,9%) participants have co-sensitization to at least one food allergen. Sensitization to following food allergens was predominant: to hazelnut – in 27,5%, to apple – in 26,3%, to peanut – in 21,7%, to celery – in 14,3%, to soy – in 13,1%, to fish carp – in 11,4%, to kiwi – in 9,1%, to crab – in 9,1%, to codfish – in 8,6%, to oyster – in 8,6%, to peach – in 8%, to lobster – in 8%, to carrot – in 7,4%, to anisakis – in 6,3%, to prawn – in 6,3%, to tiger prawn – in 5,7%, to beef – in 5,1%. It was found that the frequency of sensitization to cross-reactive proteins PR-10 was 20,5% (95% CI; 9,7%-33,9%) in patients with allergic rhinitis without food co-sensitization comparing to 51,1% (95% CI; 42,5%-59,7%) in participants with both allergic rhinitis and food co-sensitization, p<0,001; to nsLTP was 2,3% (95% CI; 0-8,9%) and 19,8% (95% CI; 13,4-27,2%), respectively, p=0,011.Conclussion. In Kyiv adult population with allergic rhinitis approximately three quarters of patients have food co-sensitization, that may be the reason of exacerbations of allergic rhinitis after consuming vegetables, fruits and nuts due to cross-reactivity with inhalant allergens, that should be considered when manage such patients.
Level of Satisfaction on Abortion Service and Associated Factors Among Client Who Received Service in Public Health Facility of Mojo Town, Ethiopia
Authors: Oda Tola , Sento Midekso , Negera Atoma 
Published: July 2022

Abstract
Introduction: patient satisfaction is an important and commonly used indicator for measuring the quality in health care as it affects clinical outcomes, patient retention, and medical malpractice claims. In Ethiopia problems related to abortion were neglected and access to quality abortion care was very limited. Similarly, information related to abortion care service particularly clients’ satisfaction is limited in the study area. The aim of this study was to determine level of satisfaction on abortion service and associated factors among clients who received the service at public health facility of Mojo town. Methods: facility based cross-sectional study design was employed on 255 women who come for abortion service in public health facilities of Mojo town. Data was coded and entered in to Epi info version 7 and exported to SPSS version 20 for analysis. Bivariate and multivariate logistic regression models were used to determine the associated factors. A p-value < 0.05 was considered statistically significant. Results: the study showed that 56.5% of the clients were satisfied with abortion care service. Educational level college and above (AOR: 0.27; 95% CI: (0.74, 0.95), employee occupation (AOR: 1.86; 95%CI: (1.41, 2.93), medical abortion as type of uterine evacuation (AOR: 3.93; 95% CI: (1.75, 8.83) and natural method of family planning users (AOR: 0.36; 95% CI: (0.08, 0.60) were factors associated with abortion care service. Conclusion: the overall satisfaction towards abortion care service was considerably lower. Healthcare provider and management should act on activities that increase client satisfaction.
Data Fault Detection Using Minimum Redundancy Maximum Relevance in Combination with Support Vector
Authors: priya indira , S Muthurajkumar , S Sheeba Daisy 
Published: July 2022

Abstract
Wireless Sensor Network (WSN) refers to a network of devices that can communicate the informa- tion gathered from a monitored field through wireless links. WSNs measures environmental conditions like temperature, sound, pollution levels, humidity, wind, etc. WSN’s data fault detection is a challenging problem due to presence of sensors in unpredictable areas. The data fault detection has to be precise and accurate, so that it can be used for weather prediction, disease prediction etc. In recent years, Machine Learning plays a vital role in accurate fault Detection. To make the detection process accurate it is mandatory to reduce the number of input features to the Support Vector Machine (SVM). Minimum Redundancy Maximum Relevance (MRMR) which is an efficient feature selection algorithm is proposed in this work. The feature set is used to train the Support Vector Machine (SVM) to detect data faults. The data fault detection accuracy is calculated which shows the accuracy of 92.9% for smaller test data and accuracy of 97.2% for larger test data.
Synthesis and structure characterization of N-[5-cyano-4-(morpholin-4-yl)-6-phenylpyrimidin-2-yl]benzenesulfonamide
Authors: Mohamed-Ezzat Reham A. , Azzam Rasha , Kariuki Benson. M. 
Published: July 2022

Abstract
Sulfonamides are a class of compounds with a wide range of biological activities. The synthesis of a novel sulfapyrimidine derivative is reported in this article. The approach to the synthesis of the compound is based on reacting N-(6-Chloro-5-cyano-4-p-tolylpyrimidin-2-yl) benzenesulfonamide and morpholine to afford N-[5-cyano-4-(morpholin-4-yl)-6-phenylpyrimidin-2-yl]benzenesulfonamide. The title compound incorporates three pharmacophores, namely the (i) pyrimidine, (ii) morpholine, and (iii) benzenesulfonamide moieties. Each of these groups possesses a characteristic set of chemical reactivity and biological activities. The newly synthesized compound is anticipated to possess significantly enhanced pharmacological features. The structure of the compound was confirmed by spectroscopic and single crystal x-ray diffraction techniques.
Virulence of Beauveria sp. and Metarhizium sp. fungi towards Fall armyworm (Spodoptera frugiperda)
Authors: Apirajkamol Nonthakorn (Beatrice) , Hogarty Timothy Michael , Mainali Bishwo , Taylor Phillip Warren , Walsh Thomas Kieran , Tay Wee Tek 
Published: July 2022

Abstract
Since 2016, the fall armyworm (Spodoptera frugiperda, J.E. Smith) has spread from the Americas to invade many regions of the world, including Australia in early 2020. The development of effective pest management strategies for S. frugiperda is a high priority for crop protection. In the invasive range, the degree to which endemic biological control agents can constrain S. frugiperda remains sparsely investigated. This study examines 11 isolates of fungi including six Beauveria isolates and five Metarhizium isolates from Oceania for their potential as S. frugiperda biocontrol. Two Beauveria isolates (B-0571, B-1311) exhibited high virulence toward S. frugiperda caterpillars and adults. The overall mortalities over seven days in 3rd and 6th instar caterpillars and moths (respectively) for B-0571 was 82.81±5.75, 61.46±6.83, and 93.75±3.61, and for B-1311 was 73.72±2.51, 71.88±5.41, and 97.92±2.08%. The majority of deaths in the caterpillars occurred within the first 24 hours (3rd instar control 0.74±0.33%, B-0571 73.96±7.85 and B-1311 62.08±3.67%; 6th instar control 0%, B-0571 66.67±11.02% and B-1311 62.5±9.55%). Infection from both isolates fully prevented reproduction in surviving S. frugiperda females. The two isolates, however, cause a significantly lower mortality in a native noctuidae species: Helicoverpa armigera (3rd instar B-0571 44.79±4.54% and B-1311 19.80±7.51%). The discovery of two fungal isolates with high virulence to S. frugiperda caterpillars and adults opens new avenues for the development of biological control tools for this invasive moth pest. Such tools may also provide additional options for control of native pest lepidoptera, and reduce selection pressure for resistance to Bt and synthetic insecticides.
Reduction of emotional eating with a mindfulness-based group training:
a randomized controlled experience-sampling study
Authors: Macht Michael 
Published: July 2022

Abstract
Purpose
Emotional eating, i.e., a habitual pattern to eat in order to cope with negative emotions, is associated with increased intake of sweet and fatty foods, overweight and binge eating. We investigated whether a mindfulness-based cognitive-behavioural group training can reduce this eating pattern in everyday life.
Methods
Female emotional eaters attended 7 weekly training sessions (intervention: n = 18) or received written information on healthy eating (control: n = 32). The characteristics of their eating behaviour and emotion regulation were obtained with standardized questionnaires and experience sampling in randomly selected situations of everyday life before and during training as well as 2 weeks and 3 months thereafter.
Results
The training reduced emotional and external eating, improved skills to regulate emotions and to enjoy food. The changes in emotional eating were demonstrated both by questionnaires and experience sampling in situations of everyday life. Three months after training, emotional and external eating were still reduced.
Conclusion
Results confirm previous evidence that mindfulness-based, cognitive-behavioural techniques can be an effective tool to reduce emotional eating in the sub-clinical population. Future studies may investigate the use of this training for prevention and treatment of eating disorders and obesity.
Level of evidence:
Level I, randomized controlled trial
Carbon stock of Agoro Agu Central Forest Reserve, in Lamwo District, Northern Uganda
Authors: Birungi Vicent , Workeneh-Dejene Sintayehu , Mbogga Michael S , Dumas-Johansen Marc 
Published: July 2022

Abstract

Uganda has since not undertaken carbon stock inventories for these conservation areas, especially with dry Afromontane forests like Agoro-agu central forest reserve (CFR). This study was carried out to estimate carbon stock of Agoro-agu CFR, for its potential in climate change mitigation. A stratified sampling design was used, where 65 sample plots were established. Nested, fixed area circular sample plots with sub-plots of varying radii for tree height, diameter measurements and soil sampling. The mean total carbon stock of Agoro-agu CFR was estimated at 606.7 mg ha-1, for which 409, 72, 124 and 0.24 mg ha-1 was stored as above ground carbon, below ground carbon, soil organic carbon and carbon in litter herbs and grass respectively. The study illustrates the carbon sequestration potential of the forest for any results-based payment projects for climate change mitigation, which calls for multi-stakeholders’ collaboration from direct resource users to national level to enhance forest conservation and reduce forest degradation.
A NLOS Identification Algorithm of UWB Signal via Temporal Convolutional Neural Network and Attention Mechanism
Authors: Wang Haowen , Tan Yifan , Li Peiqin 
Published: July 2022

Abstract
The accurate identification of Non-line of Sight (NLOS) propagation is an important premise to ensure the positioning accuracy in UWB indoor positioning system. In this paper, a network which takes the channel impulse response (CIR) as the input and combines the temporal convolutional network (TCN) and attention mechanism is proposed to identify the NLOS propagation. Based on the framework, particle swarm optimization (PSO) algorithm is used to select the key parameters of the network to achieve higher accuracy and faster process speed. Experiments on the open source dataset show that the identification accuracy of the network reaches 89.80%, which is better than the existing mainstream long short-term memory neural network. The proposed network is further improved by using six extra characteristics and its validation accuracy can reach 91.08% with a relatively high convergence rate. Also, the accuracy and computational amount of the network can be balanced by adjustment of CIR length according to the needs in practical application, indicating that the network has a good application prospect.
Curcumin reversed cigarette smoke extract-induced epithelial-to-mesenchymal transition of human bladder cancer cell UMUC3 through suppression of ERK1/2 pathway
Authors: Sun Xin , Zhang Tao , Tang Liang , Min Jie , Yu Dexin 
Published: July 2022

Abstract
Cigarette smoke (CS) is a main risk factor for bladder cancer (BC). The epithelial-to-mesenchymal transition (EMT), termed as an embryonic program, participates in the development process of CS-associated BC. Over the last decade, the effects and mechanisms of curcumin on CS-related BC have been extensively investigated. However, it's still elusive if MAPK pathways participate in curcumin-associated protective effect against CS-related promotive role in BC. In this study, our results showed that the exposure of BC cells UMUC3 to cigarette smoke extract (CSE) induced morphology variation, reinforced migratory and invasive abilities, decreased epithelium biomarker expression and increased mesenchyme biomarker expression. Meanwhile, CSE administration led to the stimulation of extracellular regulated protein kinases 1 and 2 (ERK1/2) and activator protein 1 (AP-1) proteins, without validly activating the Jun N-terminal kinase (JNK), p38 or ERK5 pathway. Moreover, CSE-elicited EMT and ERK1/2/AP-1 stimulation were completely diminished by U0126, a pharmacological inhibitor targeting ERK1/2. Furthermore, the co-treatment with low concentrations of curcumin significantly abolished CSE-elicited EMT in UMUC3 cells, and the ERK1/2/AP-1 pathway was implicated in the suppressive effect. In summary, these data indicated the modulatory effects of ERK1/2 on CSE-elicited urocystic EMT in vitro and the chemoprevention efficacy of curcumin.
Factors Influencing Homeowners' Decision to Purchase Flood Insurance in Flood-prone Areas of Imo State, Nigeria
Authors: Onyike Joachim Abiahu , Onuoha Iheanyi , Gerald-Ugwu Gladys 
Published: July 2022

Abstract
Severe floods have become an annual experience in Imo State inflicting losses of lives and property on the population. The most affected areas are Oguta, Ohaji/Egbema and Owerri. This situation notwithstanding, most homeowners in these areas have not taken advantage of flood insurance facility. This study attempts to identify the factors affecting homeowners' flood insurance purchase decisions in Oguta, Ohaji/Egbema and Owerri, and to apply discriminant analysis technique on those factors to determine whether or not there are significant differences in perception between those willing to purchase flood insurance and those not willing. The study equally seeks to determine the variables that best account for the differences in perception between the two groups. Tests using Wilks’ lambda, eigenvalues, canonical correlation, functions at group centroids, and classification accuracy were applied on identified sets of relevant determinants. The study found that those willing to purchase flood insurance were more concerned with the mitigation of flood catastrophe, apparently because they are worst hit by the floods, while those who were not willing were more indifferent as they appear to be less certain and aware of flood insurance. However, the variables with the most predictive power in accounting for the differences in perception and have the highest impact were found to be within the measures of behavioral, attitudinal and emotional determinants. The study therefore concludes that the likelihood of purchasing flood insurance in the study areas depends greatly on information availability, consumers’ insurance literacy and level of trust on the integrity of insurance companies.
Dormant senescence-prone cells (DSPC): a lifetime memory about systemic genotoxic stress
Authors: Leonova Katerina , Gitlin Ilya , Gleiberman Anatoli , Toshkov Ilia , Trageser Nicholas , Issaeva Natalia , Antoch Marina , Gudkov Andrei 
Published: July 2022

Abstract
Systemic genotoxic stress is expected to generate senescent cells and accelerate aging. Surprisingly, mice subjected to lethal dose of total body irradiation and rescued by bone marrow transplantation (TBIBMT) showed neither gain of aging-related frailty nor increase in senescence markers. Mesenchymal cells in various tissues of TBIBMT mice do not undergo senescence and stay dormant with unrepaired DNA breaks during the entire life of the animal and activate senescence program only after they are forced into cell divisions ex vivo or in vivo. Accumulation of such dormant senescence-prone cells (DSPC) has no physiological effects under normal life conditions but is associated with impaired wound healing, decelerated tumor growth due to inefficient scaring and stroma formation and rapid increase in frailty and death after placement on a high-fat diet suggesting the involvement of DSPC accumulation in obesity-induced health decline in cancer survivors following genotoxic treatments.
Mechanical properties, degree of sclerotisation and elemental composition of the gastric mill in the red swamp crayfish Procambarus clarkii (Decapoda, Crustacea)
Authors: Krings Wencke , Brütt Jan-Ole , Gorb Stanislav N. 
Published: July 2022

Abstract
The gastric mill of Decapoda is a unique feature consisting of interacting teeth, stabilizing ossicles, and particle sorting setae. As this organ is involved in the mechanical fragmentation of the food, it serves as interface between organism and environment. There is an ongoing debate to which extend structures are shaped due to phylogeny or to ecology. As material properties complement morphology and hold information about functionality and trophic preferences, we here aim at providing a basis for more intensely comparative research on material composition and properties of gastric mill components. Data on the micro-structure, documented via scanning electron microscopy (SEM), on the elemental composition, determined by energy-dispersive X-ray spectroscopy (EDX, EDS), on the heterogeneities in material properties, visualized by confocal laser scanning microscopy (CLSM), and on the mechanical properties hardness and elasticity (i.e., Young’s modulus), tested by nanoindentation technique, of gastric mill components from the red swamp crayfish Procambarus clarkia is here presented. The elemental composition of gastric mill components was studied previously in other taxa, but the mechanical properties were never tested before. As epicuticle and exocuticle could be analyzed individually, due to rather large thickness of the epicuticle, material property gradients, with values decreasing from the interacting surface towards interior, could be determined. Finally, we were able to relate the mechanical property data and the autofluorescence signals with the elemental composition and the degree of tanning.