bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIFAT KIMIA DAN ORGANOLEPTIK BAKSO DAGING KERBAU DENGAN PENAMBAHAN TEPUNG TALAS LOKAL PADA LEVEL BERBEDA
Authors: Anjalani Ria , Astuti Maria Haryulin , Pertiwi Febriana Dewi 
Published: February 2022

This study aimed to find out the effect of adding local taro flour at different levels on the chemical and organoleptik properties of buffalo meatballs. This study used a Completely Randomized Design with 5 treatments and 4 replications for each treatment i.e. P0 (100% tapioca flour), P1 (87,5% tapioca flour and 12,5% taro flour), P2 (75% tapioca flour and 25% taro flour), P3 (62,5% tapioca flour and 37,5% taro flour), and P4 (50% tapioca flour and 50% taro flour). Chemical properties of buffalo meatballs were analyzed with variance analysis and further results were evaluated by Tukey Test. Organoleptic properties of buffalo meatballs were analyzed non parametrically by Friedman Test. The difference percentage of taro flour showed a significant different on dry matter and protein content of buffalo meatballs (P<0.05). However, it showed a non significant difference on fat content of buffalo meatballs (P>0.05). The difference percentage of taro flour also showed a non significant difference on organoleptic properties of buffalo meatballs (P>0.05). The best of dry matter, protein, and fat content were obtained in P0 and P2 at 30.51%; 9.08%; and 1.13%, respectively. Color, taste, and flavor of meatballs were preferred by panelists in P0. Texture and elasticity of meatballs were preferred by panelists in P1.
Analisis Efektivitas Penggunaan Kartu Tani di Eks-Karesidenan Pati
Authors: Isabella Mesiastri Prisnia , Sunaryanto Lasmono Tri 
Published: February 2022

Tujuan penelitian ini adalah menganalisis efektivitas penggunaan Kartu Tani di Eks-Karesidenan Pati. Pemilihan lokasi menggunakan teknik multistage purposive sampling dan simple random sampling. Multistage purposive sampling untuk menentukan kabupaten dan simple random sampling untuk menentukan kecamatan dan desa. Penelitian ini menggunakan deskriptif kuantitatif. Variabel penelitian ini yaitu keberhasilan program (X1), keberhasilan sasaran (X2) dan kepuasan terhadap program (X3). Hasil penelitian ini, menunjukkan bahwa variabel keberhasilan program(X1), keberhasilan sasaran (X2), dan kepuasan terhadap program (X3) berpengaruh secara signifikan terhadap efektivitas penggunaan kartu tani. Kata kunci: Efektivitas, Kartu Tani, Keberhasilan Program, Keberhasilan Sasaran, Kepuasan Terhadap Program
KONTRIBUSI PRODUK SEKUNDER AMPAS TAHU PADA USAHA INDUSTRI RUMAH TANGGA UD. DUA PUTRI DI DESA GUNUNG ANTASARI KECAMATAN SIMPANG EMPAT KABUPATEN TANAH BUMBU PROVINSI KALIMANTAN SELATAN
Authors: Mahyudi Fitri , Husinsyah Husinsyah 
Published: February 2022

This Research aim to know technically about Seconder Product Contribution of Tofu Dregs UD Dua Putri Home Industries in Gunung Sari Village Simpang Empat Subdistrict Tanah Bumbu Regency City South Kalimantan Province. From result of knowable analysis that level of amount of acceptance from result of processing know Rp. 5.040.000/day and Rp. 151.200.000/month. Others at this tofu home industry there are addition of acceptance from tofu dregs know yield up with detail in 1 day yield 230 kg /day and 6.900 kg dregs each month. Price sell tofu dregs know per kg Rp.1.000,-, hence result of total acceptance from tofu dregs know equal to Rp. 230.000/day and Rp.6.900.000/month. Become total acceptance from effort UD. Two Putri tofu home industry equal to Rp.5.270.000,-/Hari and Rp. 158.100.000,-/month. From result analyse known benefit effort processing know equal to Rp. 61.508.652,79,/month.
MORFOGENESIS EKSPLAN TUNAS EUCALYPTUS PELLITA F. MUELL SECARA IN VITRO PADA MEDIA MURASHIGE AND SKOOG DENGAN ZAT PENGATUR TUMBUH BENZIL AMINO PURIN
Authors: Sulichantini Ellok Dwi , Eliyani Eliyani , Dewi Nazari Alvera Prihatini 
Published: February 2022

Eucalyptus pellita is fast growing species and have many advantages such as: pulp and paper industry raw material, building construction, charcoal, and medicine. The research was carried out to study plant morphogenesis from shoot explant of E. pellita F. Muell by in vitro technique. The experiment was conducted at Tissue Culture Laboratory, Agriculture Faculty of Mulawarman University from March until June, 2016.Single factor experiment was arranged in Completely Randomized Design with 10 replications. The factor was BAP concentrations (B) consisted of 1.00 mg BAP L-1 (b1); 2.00 mg BAP L-1 (b2); 3.00 mg BAP L-1 (b3); and 4,00 mg BAP L-1 (b4). The explants was innoculated on MS medium supplemented with BAP according to the treatments. Data analyzed by analysis of variance (anova) and continued by Least Significant Difference (LSD) test with level 5%. Results of the experiment showed that the BAP concentrations can promote shoot formation of E. pellita. Statistical analysis indicated that the effect of BAP concentrations significantly difference on number of shoots at 8 weeks after innoculation (WAI), shoot length, and number of leaves at 4; 6; and 8 WAI, however it’s no significantly difference on shoot formation time and number of shoots at 4 and 6 WAI. The highest number of shoots, shoot length, and number of leaves achieved by 4,00 mg BAP L-1.
STRATEGI MENINGKATKAN VOLUME PENJUALAN KRIPIK TEMPE DI MASA PANDEMI PADA HOME INDUSTRY SUMBER AGUNG, PETORAN, JEBRES, SURAKARTA
Authors: Desma Rahadhini Marjam , Lamidi Lamidi 
Published: February 2022

Kegiatan pengabdian kepada masyarakat ini, mengambil obyek home industry Sumber Agung di Petoran, Jebres, Surakarta. Tujuan dilakukan pengabdian untuk memberikan pelatihan dan penyuluhan kepada pengelola home industry Sumber Agung agar mampu beradaptasi terhadap perubahan tehnologi informasi, dalam upaya mengelola dan mengembangkan usahanya, serta membantu memberikan solusi untuk mengatasi permasalahan yang dihadapi, khususnya pada aspek pemasaran produk.Beberapa permasalahan yang dihadapi, antara lain: 1) pada masa pandemi covid 19 penjualan kripik tempe mengalami penurunan yang sangat signifikan, sekitar 50%. 2) proses pengirisan tempe hanya dilakukan secara manual, padahal dalam kondisi normal dapat menghabiskan bahan baku kedelai 70 kg/hari, akibatnya tidak efisien dalam produksi, 3) pemilik belum memahami makna pentingnya branding dan packing. Metode pelaksanaan pengabdian ini dengan melakukan pendampingan dalam bentuk pelatihan dan penyuluhan pada home industry Sumber Agung. Secara tehnis dengan mengadakan pelatihan penggunaan media sosial (whatsapp, facebook dan instagram) dan penyuluhan tentang pentingnya memahami branding dan packing. Hasil dari kegiatan pendampingan ini, facebook yang digunakan ”Kripik Sumber Agung” dan instagram yang digunakan “Sumberagungsolo”. Luaran dari kegiatan pengabdian ini, artikel pengabdian yang dimuat di Jurnal Pengabdian Terakreditasi Nasional.
Kata kunci: kripik tempe, pendampingan, sosial media
A Portable Molecularly Imprinted Sensor for On-Site and Wireless Environmental Bisphenol A Monitoring
Authors: Beduk Tutku , Gomes Matilde , De Oliveira Filho José Ilton , Shetty Saptami Suresh , Khushaim Walaa , Garcia-Ramirez Ricardo , Durmus Ceren , Ait Lahcen Abdellatif , Salama Khaled Nabil 
Published: February 2022

The detection of pollutant traces in the public and environmental waters is essential for safety of the population. Bisphenol A (BPA) is a toxic chemical widely used for the production of food storage containers by plastic industries to increase the storage ability. However, the insertion of BPA in water medium leads to serious health risks. Therefore, the development of low-cost, practical, sensitive, and selective devices to monitor BPA levels on-site in the environment is highly needed. Herein, for the first time, we present a homemade portable potentiostat device integrated to a laser-scribed graphene (LSG) sensor for BPA detection as a practical environmental pollutant monitoring tool. Recently, there has been an increasing need regarding the development of graphene-based electrochemical transducers (e.g., electrodes) to obtain efficient biosensing platforms. LSG platform is combined with molecularly imprinted polymer (MIP) matrix. LSG electrodes were modified with gold nanostructures and PEDOT polymer electrodeposition to create a specific MIP biomimetic receptor for ultrasensitive BPA detection. The sensing device has a Bluetooth connection, wirelessly connected to a smartphone providing high sensitivity and sensitivity (LOD: 3.97 nM in a linear range of .01–10 µM) toward BPA. Two commercial bottled water samples, tap water, commercial milk, and baby formula samples have been used to validate the reliability of the portable sensor device.
Dissecting the Polygenic Basis of Primary Hypertension: Identification of Key Pathway-Specific Components
Authors: Maj Carlo , Salvi Erika , Citterio Lorena , Borisov Oleg , Simonini Marco , Glorioso Valeria , Barlassina Cristina , Glorioso Nicola , Thijs Lutgarde , Kuznetsova Tatiana , Cappuccio Francesco P. , Zhang Zhen-Yu , Staessen Jan A. , Cusi Daniele , Lanzani Chiara , Manunta Paolo 
Published: February 2022

Introduction and ObjectivesGenome-wide association studies have identified a high number of genetic loci associated with hypertension suggesting the presence of an underlying polygenic architecture. In this study, we aimed to dissect the polygenic component of primary hypertension searching also for pathway-specific components.MethodsThe polygenic risk score (PRS) models, based on the UK biobank genetic signals for hypertension status, were obtained on a target Italian case/control cohort including 561 cases and 731 hyper-normal controls from HYPERGENES, and were then applied to an independent validation cohort composed by multi-countries European-based samples including 1,284 cases and 960 hyper-normal controls.ResultsThe resulting genome-wide PRS was capable of stratifying the individuals for hypertension risk by comparing between individuals in the last PRS decile and the median decile: we observed an odds ratio (OR) of 3.62, CI = [2.01, 6.32] (P = 9.01E-07) and 3.22, 95% CI = [2.06, 5.10] (P = 6.47E-08) in the target and validation cohorts, respectively. The relatively high case/control ORs across PRS quantiles corroborates the presence of strong polygenic components which could be driven by an enrichment of risk alleles within the cases but also by potential enrichment of protective alleles in the old normotensive controls. Moreover, novel pathway-specific PRS revealed an enrichment of the polygenic signal attributable to specific biological pathways. Among those the most significantly associated with hypertension status was the calcium signaling pathway together with other mainly related such as the phosphatidylinositol/inositol phosphate pathways.ConclusionsThe development of pathway-specific PRS could prioritize biological mechanisms, according to their contribution to the genetic susceptibility, whose regulations might be a potential pharmacological preventive target.
The Seismic Early Warning System of Mexico (SASMEX): A Retrospective View and Future Challenges
Authors: Suárez Gerardo 
Published: February 2022

The earthquake early warning system of Mexico, SASMEX, has 30 years of uninterrupted and successful operation. During this time, the system recorded ∼9,800 earthquakes and broadcast 111 alerts. Alerting was simplified recently, avoiding the emission of two types of alerts. Only earthquakes above a magnitude threshold, dependent on distance to the target city are alerted. SASMEX disseminates early warnings using dedicated receivers, public loudspeakers, multi-hazard radios, and participating TV and radio stations. It is estimated that ∼25 million people receive alert messages from SASMEX. Cell-broadcasting messaging, necessary for the timely delivery of alerts, is not implemented by the local cellular phone operators. The addition of cell phone communication would increase the number of users benefitting from the system. SASMEX does not publish ground motion predictions at the time of issuing the alert.Instead, it distributes a map of peak ground acceleration in Mexico City ∼1 minute after the arrival of strong motion, via electronic messaging. The accepted practice for the population in general is to evacuate at the sound of the alert. This is useful in schools and low-rise buildings, where people are generally drilled to evacuate rapidly. It is not effective in high-rise buildings and where large numbers of people concentrate. Finding protection and not trying to evacuate may be a better option, as it is recommended by other seismic early warning systems. The damaging 19 September 2017 earthquake underlined the difficulties of alerting earthquakes at close distances. Using a different sound of the alert or a countdown may be advisable, so people understand they have less time than normally assumed. There are few social studies on the use of the alert. It is suggested to conduct these studies to explore better ways to use and communicate the seismic alert, including automatic processes to shut down hazardous facilities.
A Bidirectional Relationship Between Hyperuricemia and Metabolic Dysfunction-Associated Fatty Liver Disease
Authors: Yang Chengzhang , He Qianjin , Chen Ze , Qin Juan-Juan , Lei Fang , Liu Ye-Mao , Liu Weifang , Chen Ming-Ming , Sun Tao , Zhu Qian , Wu Yonglin , Zhuo Ming , Cai Jingjing , Mao Weiming , Li Hongliang 
Published: February 2022

Background and aimsMetabolic dysfunction-associated fatty liver disease (MAFLD) is a newly emerged term that is suggested to better reflect the pathogenesis of nonalcoholic fatty liver disease (NAFLD); however, the association between hyperuricemia and MAFLD has not been explored in the Chinese population. Meantime, this study also examined the temporal relationship between the two entities in a longitudinal cohort.MethodsWe conducted a retrospective cross-sectional study including 1,587,962 individuals from 19 health check-up centers in China from 2009-2017 and a longitudinal study with 16,112 individuals. A logistic regression model was applied to determine the association between hyperuricemia and MAFLD in a cross-sectional study. The Cox regression model was used to explore the association between hyperuricemia at baseline and subsequent onset of MAFLD or the association between the presence of MAFLD at baseline and the subsequent incidence of hyperuricemia. The cross-lagged analysis was applied to exam the temporal relationship between hyperuricemia and MAFLD.ResultsIn the cross-sectional study, hyperuricemia showed a strong positive association with MAFLD after controlled potential confounders. In the longitudinal cohorts, hyperuricemia at baseline was associated with the new-onset of MAFLD, with a hazard ratio (HR) of 1.765 (95% CI: 1.512, 2.060). Interestingly, baseline MAFLD was also associated with the subsequent incidence of hyperuricemia, with an HR of 1.245 (95% CI: 1.106, 1.400). The cross-lagged path analysis revealed a bidirectional relationship between hyperuricemia and MAFLD.ConclusionsThe results suggested that hyperuricemia and MAFLD form a vicious cycle, resulting in more deterioration of metabolic status.
Molecular Characteristics, Oncogenic Roles, and Relevant Immune and Pharmacogenomic Features of EVA1B in Colorectal Cancer
Authors: Ma Bin , Wang Kangchun , Liang Yu , Meng Qingkai , Li Yongmin 
Published: February 2022

ObjectiveEVA1B, a protein coding gene, is a critical paralog of EVA1A gene. Herein, our study was conducted to investigate the role of EVA1B in colorectal cancer (CRC) progression and prognosis.MethodsPan-cancer analysis was conducted to analyze expression, genetic and epigenetic alterations, and immunological characteristics of EVA1B. Especially, immunological characteristics and mutational landscape were compared between high and low EVA1B expression groups in the combined TCGA-COAD and TCGA-READ datasets. Through random survival forest analysis, an EVA1B-derived genomic model was developed, and its prognostic value was verified in the external datasets (GSE14333, GSE39582, and GSE87211). Drug sensitivity was compared between high- and low-risk subpopulations. A nomogram was conducted through integrating independent factors.ResultsEVA1B expression presented a remarkable upregulation in most cancer types, especially CRC. EVA1B expression was significantly correlated to DNA methyltransferases, DNA mismatch repair genes, m6A regulators, TMB, and MSI across pan-cancer. High EVA1B expression indicated an undesirable CRC patients’ prognosis. Additionally, its upregulation was correlated to enhanced immune cell infiltration, increased stromal and immune activation, and elevated activities of cancer immunity cycle. Higher frequencies of amplification and deletion were investigated in high EVA1B expression subpopulation. Following verification, the EVA1B-derived genomic model reliably predicted patients’ prognosis and drug responses. The nomogram (age, stage, EVA1B-derived risk score) was conducted to quantify an individual’s survival probability. Furthermore, our experimental validation based on immunohistochemistry indicated that EVA1B overexpression is correlated with CRC tumorigenesis and poor outcomes in our CRC patients’ cohort.ConclusionCollectively, our findings provided valuable resource for guiding the mechanisms and therapeutic analysis of EVA1B in CRC.
Factors Associated With Undergraduate Nursing Students' Academic and Clinical Performance: A Mixed-Methods Study
Authors: Fooladi Ensieh , Karim Md Nazmul , Vance Sheila , Walker Lorraine , Zanjani Maya Ebrahimi , Ilic Dragan , Brand Gabrielle 
Published: February 2022

BackgroundThere is conflicting and limited information regarding factors that influence undergraduate nursing students' academic and clinical performance prior to entry to practice.ObjectiveTo identify factors influencing the academic and clinical performance of undergraduate nursing students throughout the course.DesignMixed methods study utilizing a retrospective cohort and a qualitative study.SettingMonash University, Melbourne, Australia.ParticipantsLongitudinal existing data of nursing undergraduate students who commenced in 2017 (n = 176) and 2018 (n = 76), and two focus groups with final year nursing students were analyzed.MethodsRetrospective students' records were used to determine the students' academic and clinical performance using the weighted average mark (WAM) of the theoretical and clinical components of the curriculum, separately. The WAM considered the year level of each unit and was scored out of 100. Multivariate linear regression was used to determine predictor factors of academic and clinical performance. Variables include entry cohort (with no previous nursing qualification vs. diploma of nursing), admission category (domestic vs. international), campus (metropolitan vs. outer metropolitan), and secondary school (year 12) results. Two focus group discussions were conducted and thematically analyzed.ResultsMore than two-thirds of the students were aged 18–20 years and mainly female. Almost 20% of the participants were international students. Students with higher secondary school (year 12) results and studying at the outer metropolitan campus achieved a higher academic performance while international students had significantly lower academic performance compared to domestic students. Students with a previous diploma of enrolled nursing and international students had lower clinical performance. Students identified that a comprehensive orientation, interactive curriculum, formal and informal support structure, and educator qualities influenced their academic and/or clinical performance.ConclusionsA supportive educational environment with an interactive curriculum may enhance students' academic and clinical performance and readiness for practice. Furthermore, targeted interventions for international students, those with lower secondary school (year 12) results, and those with a former diploma of nursing may be required to increase academic and clinical performance.
Forecasting Healthy Life Expectancy Among Chilean Community-Dwelling Older Adults With and Without Sarcopenia
Authors: Moreno Ximena , Lera Lydia , Márquez Carlos , Albala Cecilia 
Published: February 2022

BackgroundSarcopenia is an important risk factor for disability and dependency at old age. The prevalence of sarcopenia among the Chilean older population is high.ObjectiveTo estimate life expectancy, healthy life expectancy and unhealthy life expectancy among sarcopenic and non-sarcopenic older adults from Santiago, Chile.MethodsA sample of 1,897 community-dwelling older adults aged 60 years or more, living in Santiago, was observed between 5–15 years. Disability was defined as the unhealthy state, assessed through self-reported difficulties in activities of daily living. Sarcopenia was determined via HTSMayor software. Total and marginal life expectancies were estimated using the Interpolated Markov Chain method “IMaCh”.ResultsAt 60 years, estimated life expectancy for sarcopenic and non-sarcopenic older adults was similar (22.7 and 22.5 years, respectively). The proportion of years to be lived with disability was three times greater in sarcopenic adults, compared to non-sarcopenic people. This difference was observed up to 80 years. Non-sarcopenic women had a higher proportion of years to be lived with disabilities compared to non-sarcopenic men of the same age, but this proportion was higher among sarcopenic men, compared to sarcopenic women until 70 years of age.DiscussionPeople with sarcopenia expect to live a higher proportion of years with disabilities. Sarcopenic men until 70 years expected to live a higher proportion of years with disability, compared to sarcopenic women. Monitoring sarcopenia among older people may help to identify individuals with higher risk of disability onset. Future research should focus on disentangling the mechanisms explaining sex differences.