bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating miR-30b-5p is upregulated in Cavalier King Charles Spaniels affected by early myxomatous mitral valve disease
Authors: Bagardi Mara , Ghilardi Sara , Zamarian Valentina , Ceciliani Fabrizio , Brambilla Paola G. , Lecchi Cristina 
Published: March 2022

AbstractThere is a growing interest in developing new molecular markers of heart disease in young Cavalier King Charles Spaniels affected by myxomatous mitral valve disease. The aim of the study was to measure the abundance of 3 circulating microRNAs and their application as potential biomarkers in the plasma of Cavalier King Charles Spaniels with early asymptomatic myxomatous mitral valve disease. 33 dogs affected by the disease in American College of Veterinary Internal Medicine (ACVIM) stage B1 were divided in three groups (11 younger than 3 years, 11 older than 3 years and younger than 7 years, and 11 older than 7 years), and 11 healthy (ACVIM stage A) Cavalier King Charles Spaniels were included as the control group. This is a prospective cross-sectional study. The abundance of three circulating microRNAs (miR-1-3p, miR30b-5p, and miR-128-3p) was measured by quantitative real-time PCR using TaqMan® probes. Diagnostic performance was evaluated by calculating the area under the receiver operating curve (AUC). miR-30b-5p was significantly higher in ACVIM B1 dogs compared to ACVIM A subjects, and the area under the receiver operating curve was 0.79. According to the age of dogs, the abundance of miR-30b-5p was statistically significantly higher in group B1<3y (2.3 folds,P= 0.034), B1 3-7y (2.2 folds,P= 0.028), and B1>7y (2.7 folds,P= 0.018) than in group A. The area under the receiver operating curves were fair in discriminating between group B1<3y and group A (AUC 0.780), between B1 3-7y and A (AUC 0.78), and good in discriminating between group B1>7y and A (AUC 0.822). miR-30b-5p changed in the plasma of dogs at the asymptomatic stage of disease, particularly at a young age.
Fgf8 dosage regulates jaw shape and symmetry through pharyngeal-cardiac tissue relationships
Authors: Zbasnik Nathaniel , Dolan Katie , Buczkowski Stephanie A. , Green Rebecca , Hallgrimsson Benedikt , Marcucio Ralph S. , Moon Anne M. , Fish Jennifer L. 
Published: March 2022

ABSTRACTBackgroundAsymmetries in craniofacial anomalies are commonly observed. With respect to the facial skeleton, the left side is more commonly and/or severely affected than the right. Such asymmetries complicate treatment options. Mechanisms underlying variation in disease severity between individuals as well as within individuals (asymmetries) are still relatively unknown.ResultsDevelopmental reductions in Fibroblast growth factor 8 (Fgf8) have a dosage dependent effect on jaw size, shape, and symmetry. Further, Fgf8 mutants have directionally asymmetric jaws with the left side being more affected than the right. Defects in lower jaw development begin with an early disruption to Meckel’s cartilage, which is discontinuous and appears as two separate condensations in Fgf8 mutants. All skeletal elements associated with the proximal condensation are dysmorphic in the mutants, which is exemplified by a malformed and mis-oriented malleus. At later stages, Fgf8 mutants exhibit syngnathia, which falls into 2 broad categories: bony fusion of the maxillary and mandibular alveolar ridges and zygomatico-mandibular fusion. All of these morphological defects exhibit both inter- and intra-individual variation.ConclusionsWe hypothesize that these asymmetries are linked to asymmetries in heart development resulting in higher levels of Fgf8 on the right side of the face during development, which may buffer the right side to mild developmental perturbations. This mutant mouse is a good model for future investigations of mechanisms underlying human syngnathia and facial asymmetry.
Linking self-congruity, perceived quality and satisfaction to brand loyalty in a tourism destination: the moderating role of visit frequency
Authors: Tran Phuong Kim Thi , Nguyen Phong Dong , Le Angelina Hanh Nhat , Tran Vinh Trung 
Published: March 2022

PurposeThis study aims to examine the direct and indirect relationship between self-congruity and destination brand loyalty (DBL) based on the conceptual linkages of cognition, affect and conation. A multiple-step, multiple mediator model is investigated to explain the indirect effect of self-congruity on DBL through perceived destination quality (PDQ) and tourist satisfaction (TS). The moderating impact of visit frequency in these relationships is also proposed and empirically evaluated.Design/methodology/approachThe conceptual model and research hypotheses were assessed by applying covariance-based structural equation modeling (SEM), mediating and multi-group analysis. An online survey was used to collect data from 347 domestic tourists visiting a destination in Vietnam.FindingsThe results support the link from self-congruity to PDQ, TS and then to DBL. Visit frequency was found to moderate the links between the research concepts.Research limitations/implicationsFuture research would benefit from considering other self-congruity components (e.g. social self-congruity and ideal social self-congruity) and moderating variables (e.g. cultural distance). This would provide insights into the relationships between self-congruity and tourist behaviors and could be based on comparisons in different destinations to achieve more wide-ranging results.Originality/valueThe effect of self-congruity on DBL that evolves from linking self-congruity to PDQ and TS to increase DBL was examined within a tourism destination context. This study is valuable to destination managers as it provides suggestions to improve DBL.
Identifying hidden semantic structures in Instagram data: a topic modelling comparison
Authors: Egger Roman , Yu Joanne 
Published: March 2022

Purpose
Intrigued by the methodological challenges emerging from text complexity, the purpose of this study is to evaluate the effectiveness of different topic modelling algorithms based on Instagram textual data.

Design/methodology/approach
By taking Instagram posts captioned with #darktourism as the study context, this research applies latent Dirichlet allocation (LDA), correlation explanation (CorEx), and non-negative matrix factorisation (NMF) to uncover tourist experiences.

Findings
CorEx outperforms LDA and NMF by classifying emerging dark sites and activities into 17 distinct topics. The results of LDA appear homogeneous and overlapping, whereas the extracted topics of NMF are not specific enough to gain deep insights.

Originality/value
This study assesses different topic modelling algorithms for knowledge extraction in the highly heterogeneous tourism industry. The findings unfold the complexity of analysing short-text social media data and strengthen the use of CorEx in analysing Instagram content.
eWOM, destination preference and consumer involvement – a stimulus-organism-response (SOR) lens
Authors: Yadav Neha , Verma Sanjeev , Chikhalkar Rekha D. 
Published: March 2022

Purpose
This study aims to examine the moderated-mediation impact of consumer involvement and destination preference on travel intentions. Stimulus-Organism-Response (SOR) and elaboration likelihood model (ELM) guided the conceptual framework of this study.

Design/methodology/approach
Churchill’s (1979) guidelines instrumentalize the scientific development and validation of measurement scales for data collection. The authors used higher-order multivariate analyzes such as structural equation modeling (SEM) and the Hayes process model for evaluating the hypotheses. The study uses Bauer et al. (2006) method to assess the conditional indirect effects of Electronic word of mouth (eWOM) on travel intention through destination preference at varying levels of consumer involvement.

Findings
SOR and ELM model successfully explained the moderated-mediation effect of eWOM, consumer involvement and destination preference in influencing the travel intentions. Results broaden the applicability of SOR and ELM in tourism marketing. Results indicate that consumer involvement moderated the direct and indirect influence of eWOM on travel intention via destination preference, such that the eWOM influence in shaping travel intention is stronger for highly involved consumers.

Research limitations/implications
The present study broadens the applicability of integrated SOR and ELM models to explain the moderated-mediation network between eWOM and travel intentions. Study findings offer new avenues to tourism marketers for the magnified effect of eWOM for promoting tourism. Tourism marketers may use customer journeys to build destination preference through organic information exchange with prospective travelers. Future researchers and practitioners can build prescriptive and predictive models based on altered levels of consumer involvement.

Originality/value
Present study pioneers in examining the interactive effect of moderated mediation network of consumer involvement and destination preference in shaping the travel intention. Grounded in SOR and ELM model, the present study is a trailblazer to offer the integrated moderated-mediation model between eWOM, destination preference, consumer involvement and travel intention.
Health tourism: behavioural intention and protection motivation theory
Authors: Seow Ai Na , Choong Yuen Onn , Choong Chee Keong , Moorthy Krishna 
Published: March 2022

Purpose
Health tourism is recognised as a recent new pattern of taking a break while accessing health-care services overseas. Past studies have explored this research area, but few have focussed on the theoretical perspective. Applying an appropriate theoretical model to guide interventions in planning and programme development is crucial, particularly when the focus of the study is on the cognitive mediation processes of change in individual behaviour. This study aims to examine the effectiveness of the protection motivation theory with the influence of threat appraisal and coping appraisal. The purpose is to trigger the behavioural intention to engage in international health tourism.

Design/methodology/approach
A total of 299 international tourists participated in the survey. The partial least squares structural equation modelling technique was used to test the research framework. Both the measurement model and the structural model were assessed as adequate.

Findings
The empirical results demonstrate that tourists’ high risk perception must be complemented by coping ability to produce a motivational response. Further, the adaptive behaviours of international tourists are focussed more on perceived efficacy than on the perception of threats related to behavioural intentions towards health tourism.

Originality/value
The study presents an effective theoretical model intervention applicable to health tourism. Future studies should conduct a more comprehensive assessment to generate strong decision-making effectiveness from the theoretical model.
Who should provide expert opinion in emergency medicine‐related medical litigation?
Authors: Dalling Julie , Kelly Anne‐Maree , Madden Bill , Cockburn Tina 
Published: March 2022

AbstractExpert evidence plays a central role in establishing the relevant standard of care in medical litigation. In Australia, little is known about the expert witnesses who provide evidence about the standard of care provided in ED. A sample of recent published case law suggests that a proportion of expert evidence about breach of the standard of reasonable care in ED is provided by medical practitioners who are not emergency physicians and/or have no recent practice experience in an ED. This may potentially distort the identification of the relevant standard of care. In the United States, the American College of Emergency Physicians has attempted to address this issue by developing and promulgating expert witness guidelines. Is there a case for the Australasian College for Emergency Medicine to assume an advocacy role and/or develop standards in this area?
Sticky Space: Toxicity and Time in a New England City
Authors: Potts Rebecca Lea 
Published: March 2022

AbstractThis article theorises stickiness in the built environment by narrating the surfaces, histories, and religious temporalities of one clock factory turned strip club building in New Haven, Connecticut. The factory‐club building demonstrates the ways in which sticky relationality counters the smooth nostalgia demanded by heritage preservation and urban revitalisation efforts. From the radium that clung to the bones of the women who painted watches in the clock factory, to the stigma that clings to sex workers, and to the label of blight that clings to neighbourhoods, histories and values accumulate and structure our surroundings. How might sticky spaces gum up the progressive temporalities of capital accumulation? Utilising stickiness as texture and concept, this article is an enquiry into the ways that the built environment helps create, maintain, and contest the boundaries of stigma, toxicity, and time.
A thorough QTc study to evaluate the effects of oral rilzabrutinib administered alone and with ritonavir in healthy subjects
Authors: Ucpinar Sibel , Darpo Borje , Neale Ann , Nunn Philip , Shu Jin , Chu Katherine A. , Kavanagh Marianne , Xue Hongqi , Phiasivongsa Pasit , Thomas Dolca , Smith Patrick F. 
Published: March 2022

AbstractThis study aimed to define the clinically relevant supratherapeutic dose of rilzabrutinib, an oral Bruton tyrosine kinase (BTK) inhibitor, and evaluate potential effects of therapeutic and supratherapeutic exposures on cardiac repolarization in healthy subjects. This was a two‐part phase I study (anzctr.org.au ACTRN12618001036202). Part A was a randomized, open‐label, three‐period, single‐dose crossover study (n = 12) with rilzabrutinib 100 mg ± ritonavir 100 mg or rilzabrutinib 1200 mg. Part B was a randomized, double‐blind, placebo‐controlled, four‐way, single‐dose crossover study (n = 39) with matched placebo, rilzabrutinib 400 mg ± ritonavir 100 mg, or moxifloxacin (positive control). Primary objectives: part A – pharmacokinetics (PK) of rilzabrutinib ± ritonavir, safety, and optimal dose for Part B; Part B – effect of rilzabrutinib therapeutic and supratherapeutic concentration on electrocardiogram (ECG) parameters. ECGs and PK samples were serially recorded before and post‐dose. In part A, rilzabrutinib 100 mg + ritonavir led to 17‐fold area under the concentration–time curve (AUC0–∞) and 7‐fold maximum plasma concentration (Cmax) increases over rilzabrutinib alone. Rilzabrutinib 1200 mg was discontinued due to mild‐to‐moderate gastrointestinal intolerance. In Part B, rilzabrutinib 400 mg + ritonavir increased rilzabrutinib mean AUC0–∞ from 454 to 3800 ng h/mL and Cmax from 144 to 712 ng/mL. The concentration–QTc relationship was slightly negative, shallow (−0.01 ms/ng/mL [90% CI −0.016 to −0.001]), and an effect >10 ms on QTcF could be excluded within the observed range of plasma concentrations, up to 2500 ng/mL. Safety was similar to other studies of rilzabrutinib. In conclusion, rilzabrutinib, even at supratherapeutic doses, had no clinically relevant effects on ECG parameters, including the QTc interval.
Cutaneous atypical fibroxanthoma with osteoclast‐like giant cell: A rare phenomenon
Authors: Anderson Jarett D. , Alhatem Albert , Li Yang , Hurley M. Yadira 
Published: March 2022

AbstractAtypical fibroxanthoma (AFX) with osteoclast‐like giant cells is a rare entity. We present the case of an elderly woman who presented with a pink–purple dome‐shaped nodule with central hyperkeratotic crust. Biopsy revealed a cellular, dermal‐based tumor comprised of spindle, oval, and osteoclast‐like giant cells with pleomorphism. The immunohistochemistry profile supported a diagnosis of AFX with osteoclast‐like giant cells. We performed a literature review through PubMed and Google Scholar for AFX with osteoclast‐like giant cell formation and found 16 previously reported cases. We aim to provide a review and discuss features of these cases. We also discuss the pathogenesis of these osteoclast‐like cells as well as potential pitfalls in diagnosis.
Characteristics of fatal tapentadol‐related toxicity in Australia
Authors: Darke Shane , Duflou Johan , Peacock Amy , Farrell Michael , Lappin Julia 
Published: March 2022

AbstractIntroductionTapentadol is a centrally acting opioid analgesic prescribed for the treatment of moderate to severe pain. The study aimed to determine the characteristics of Australian toxicity deaths related to tapentadol.MethodsAll cases in which tapentadol use was coded contributory to death (n = 159) were retrieved from the National Coronial Information System (1 July 2000–31 December 2020).ResultsThe mean age was 48.5 (18–81) and 56% were female. Documented histories of problems with chronic pain (66%), mental health (60.4%), substance use (44%) and injecting drug use (23.3%) were common. The majority of deaths were deemed unintentional (76.1%) and in 18.9% pre‐existing disease was co‐contributory. The median peripheral blood tapentadol concentration was 1.00 mg L−1 (0.02–47.00), and the median aortic concentration was 2.05 mg L−1 (0.10–30.00). In all cases, psychoactive drugs other than tapentadol were also detected, most commonly antidepressants (72.3%), opioids (66.7%), hypnosedatives (64.2%) and gabapentinoids (43.4%). Of cases where autopsies were conducted, 27.7% were diagnosed with cardiomegaly and 18.5% with severe coronary artery stenosis. Pulmonary oedema (68.1%), aspiration of vomitus (39.5%) and acute pneumonia (26.9%) were common.Discussion and ConclusionsThe typical tapentadol‐related toxicity death involved unintentional death in the presence of multiple drugs, although a notable minority were intentional self‐harm. Multiple morbidities were common. The identification and characteristics of these cases indicate that the adverse event profile of tapentadol needs to be considered in the setting of polypharmacy.
Do large termite mounds effect woody plant phylogenetic diversity and endemism across African savannas?
Authors: Muvengwi Justice , Fritz Herve , Witkowski Ed 
Published: March 2022

AbstractAimDespite the importance of termite mounds in plant species’ taxonomic diversity, no study has quantified the effect of termite mounds on woody plant species’ phylogenetic diversity and phyloendemism. In order to understand how mounds influence phylogenetic diversity (PD), we had two objectives: (i) to determine the influence of termite mounds on PD and (ii) to determine how this varies with environmental and geographic factors.LocationAfrica.MethodWe performed a meta‐analysis on 21 studies that satisfied our selection criteria out of 369 that we initially identified. All these studies sampled woody plants that occurred on Macrotermes mounds and the surrounding savanna matrix.ResultsPart of our findings shows that termite mounds had higher PD compared with the surrounding savanna plots. We found that phyloendemism (PE) does not respond to the effects of Macrotermes mounds at small scales, that is between mounds and the savanna matrix. However, at continental scales, phyloendemism responded to environmental variables such as altitude, rainfall and temperature. Altitude and latitude acted negatively on both PD and phyloendemism, while temperature had a positive influence on both metrics.Main conclusionsWe provide the first quantification of the effect of termite mounds on woody plants’ PD in the savannas. Overall, termite mounds contribute, not only to taxonomic diversity in the savanna but also to PD of woody plants. Our analysis shows that termite mounds contribute strongly to overall savanna PD, hence the need to consider them in conservation planning.
Independent variation of avian sensitivity to climate change and trait‐based adaptive capacity along a tropical elevational gradient
Authors: Nowak Larissa , Schleuning Matthias , Bender Irene M. A. , Kissling W. Daniel , Fritz Susanne A. 
Published: March 2022

AbstractAimHow species respond to climate change is influenced by their sensitivity to climatic conditions (i.e. their climatic niche) and aspects of their adaptive capacity (e.g. their dispersal ability and ecological niche). To date, it is largely unknown whether and how species’ sensitivity to climate change and their adaptive capacity covary. However, understanding this relationship is important to predict the potential consequences of a changing climate for species assemblages. Here, we test how species’ sensitivity to climate change and trait‐based measures of their ecological adaptive capacity (i) vary along a broad elevational gradient and (ii) covary across a large number of bird species.LocationA Neotropical elevational gradient (300–3600 m.a.s.l.) in the Manú Biosphere Reserve, south‐east Peru.MethodsWe focus on 215 frugivorous bird species along a Neotropical elevational gradient. We approximate species’ sensitivity to climate change by their climatic niche breadth, based on species occurrences across South America and bioclimatic variables. In addition, we use a trait‐based approach to estimate the dispersal ability of species (approximated by their wing pointedness), their dietary niche breadth (approximated by bill width) and their habitat niche breadth (the number of used habitat classes).ResultsWe found that (i) species’ climatic niche breadth increased with elevation, while their trait‐based dispersal ability and dietary niche breadth decreased with elevation, and (ii) sensitivity to climate change and trait‐based adaptive capacity were not related across species.Main conclusionsThese results suggest different mechanisms of how species in lowland and highland assemblages might respond to climate change. The independent variation of species’ sensitivity to climate change and their trait‐based adaptive capacity suggests that accounting for both dimensions will improve assessments of species’ susceptibility to climate change and potential impacts of climate change on diverse species assemblages.
Property crime and private protection allocation within cities: Theory and evidence
Authors: Decreuse Bruno , Mongrain Steeve , van Ypersele Tanguy 
Published: March 2022

AbstractCanada exhibits no correlation between income and victimization, rich neighborhoods are less exposed to property crime, rich households are more victimized than their neighbors, and rich households and neighborhoods invest more in protection. We provide a theory consistent with these facts. Criminals within city choose a neighborhood and pay a search cost to compare potential victims, whereas households invest in self‐protection. As criminals' return to search increases with neighborhood income, households in rich neighborhoods are likelier to enter a race to greater protection driving criminals toward poorer areas. A calibration reproduces the Canadian victimization and protection pattern by household/neighborhood income.