bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triaxial tests on high ductile concrete under different environmental conditions
Authors: Li Lingling , Shi Junping , Yan Zijian , Kou Jialiang 
Published: September 2022

AbstractTriaxial compression tests were conducted on high ductile concrete (HDC) under three curing conditions to study its triaxial mechanical properties under different curing environments. The three different curing conditions are as follows: standard curing (temperature 20 ± 2°C, humidity ≥95%), water curing (temperature 15 ± 2°C, humidity ≥95%), and −20°C (−20 ± 2°C, humidity ≥85%). The variation laws of stress–strain response, peak stress, peak strain, and volume strain were analyzed for HDC under different environmental conditions. The mechanism of the effect of HDC mesostructure on strength under different curing conditions was revealed using ultrasonic and nuclear magnetic resonance detection technology. The relationship between HDC uniaxial compressive strength and ultrasonic speed was obtained by fitting the test data, and the relationship between the shear strength and temperature was provided. Results show that the peak stress of HDC under the same confining pressure increases with the rise in the curing temperature. The peak strain also decreases, and the HDC exhibits better ductility under −20°C curing. The peak stress and peak strain of HDC under the same curing conditions increase with the rise in confining pressure. HDC specimen fracture is in the composite failure mode of shear and splitting, and it cracks but does not disintegrate. The pore size is larger and the strength is lower when the pores are more harmful.
Steel fiber reinforced RC beams in pure torsion—Load‐bearing behavior and modified space truss model
Authors: Oettel Vincent 
Published: September 2022

AbstractInvestigations on steel fiber reinforced concrete (RC) beams in torsion show, that the steel fibers positively influence the torsional load‐bearing behavior. Since a systematic evaluation of the previously known test results and the derivation of a generally valid design model were lacking until recently, current codes such as Model Code 2010 do not contain any design models for the consideration of the steel fiber load‐bearing effect in the torsion design. Due to this, the existing torsion tests on steel fiber RC were summarized in a database. Furthermore, on the basis of the test results and observations, the space truss model developed by Rausch and later refined by Lampert and Thürlimann, among others, was further developed and supplemented by additional longitudinal and transverse steel fiber tension struts. This modified space truss model was validated with the database and shows good to very good predictions to the torsion test data.
Datafication, Teachers' Dispositions and English Language Teaching in Bangladesh: A Bourdieuian Analysis
Authors: Ali Md. Maksud 
Published: September 2022

AbstractThe use of (test) performance data for governing school and teachers' work, defined as datafication, has emerged as a global trend in education. However, how this trend plays out in relation to English language education in the local context, particularly in developing societies, has not received notable attention. Taking Bangladesh secondary education as a case, and drawing on Pierre Bourdieu's conceptual resources, this study highlights how datafication unfolds in schooling contexts and examines the “relations” between this trend and English language teachers' dispositions and pedagogical practices. The study employs a qualitative case study and draws on principal and teacher interviews, and classroom observation as data sources. Findings reveal that datafication has emerged as a practical logic of the schooling field, guiding schools and teachers' dispositions in specific ways, which contribute to reductive practices. Data also indicate teachers' capacity to mediate between competing logics and innovate practices, which are situated and “local.” Based on these findings, this article argues that understanding the interplay between the specific logics of schooling, language education policy and teachers' structuring dispositions is key not only to understanding the nature of pedagogical practices, but also to establishing meaningful “relations” between policy and schooling practices amid growing datafication.
The dual role of boron in vitro neurotoxication of glioblastoma cells via SEMA3F/NRP2 and ferroptosis signaling pathways
Authors: Kar Fatih , Hacioğlu Ceyhan , Kaçar Sedat 
Published: September 2022

AbstractGlioblastoma multiform (GBM) is a malignant tumor cancer that originates from the star‐shaped glial support tissues, namely astrocytes, and it is associated with a poor prognosis in the brain. The GBM has no cure, and chemotherapy, radiation therapy, and immunotherapy are all ineffective. A certain dose of Boric acid (BA) has many biochemical effects, conspicuously over antioxidant/oxidant rates. This article sought to investigate the modifies of various doses of BA on the glioblastoma concerning cytotoxicity, ferroptosis, apoptosis, and semaphorin–neuropilin signaling pathway. The Cytotoxic activity and cell viability of BA (0.39–25 mM) in C6 cells were tested at 24, 48, and 72 h using 3‐(4,5‐dimethylthiazol, 2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT). The IC50 concentration of BA at 1.56 mM was found and cell lysate used for biochemical analysis. Glutathione peroxidase 4 (GPx4) and ACLS4 levels of ferroptosis, levels of total antioxidant (TAS) and oxidant (TAS) parameters, malondialdehyde (MDA), apoptotic proteins as caspase 3 (CASP3) and caspase 7 (CASP7) were measured. The ferroptosis, semaphoring–neuropilin, apoptotic pathway markers and cell counts were analyzed with flow cytometry, Q‐PCR, Western and Elisa technique in the C6 cell lysate. BA triggered ferroptosis in the C6 cells dose‐dependently, affecting the semaphorin pathway, so reducing proliferation with apoptotic compared with untreated cell as control group (p < .05). This study revealed that BA, defined as trace element and natural compound, incubated ferroptosis, total oxidant molecules, and caspase protein in a dose‐dependently by disrupting SEMA3F in tumor cells.
Antibiogram and virulence profiling reveals multidrug resistantStaphylococcus aureusas the predominant aetiology of subclinical mastitis in riverine buffaloes
Authors: Hoque M. Nazmul , Talukder Anup Kumar , Saha Otun , Hasan Mehedi Mahmudul , Sultana Munawar , Rahman ANM Aminoor , Das Ziban Chandra 
Published: September 2022

AbstractBackgroundStaphylococcusspp. are the major causal agents of mastitis in dairy animals worldwide leading to profound economic losses and public health threats. Recently,Staphylococcus aureushas emerged as a multidrug resistant and zoonotic pathogen. This study aimed to characterizeS. aureusin subclinical mastitis (SCM) milk samples of riverine buffaloes in Bangladesh through antibiogram and virulence gene(s) profiling, and 16S rRNA gene sequencing.MethodWe characterizedS. aureusin SCM milk samples (N = 500) of riverine buffaloes through antibiogram and virulence gene(s) profiling, and 16S rRNA gene sequencing.ResultsOut of 500 milk samples tested, 188 (37.6%) were found positive for SCM. From 188 SCM samples, 291 isolates were obtained with a prevalence ofS. aureusin 37.4% (109/291) isolates. Phylogenetic analysis revealed the evolutionary divergence ofS. aureusisolates in bubaline SCM milk samples. The antibiogram profiling showed that about 96.0%S. aureusisolates were multidrug resistant (MDR). Notably, 29 and 16 isolates harboured methicillin‐resistant (mecA) and panton‐valentine leucocidin (pvl) genes, respectively, and 46 plasmid‐bearing isolates were MDR. NineStaphylococcalenterotoxins (SEs/SEls) includingsea(11.9%),sec(7.4%),sed(4.6%),seg(3.7%), andseh(3.7%) were detected with 72.48% toxinotypes comprising a single gene.ConclusionThis study therefore suggestsS. aureusas the single‐most aetiology (∼37.0%) of SCM in riverine buffaloes, and emergence of MDR, enterotoxin producing, and virulentS. aureusstrains could impose potential threats to animal welfare and public health.
The effects of age, sex, breed, diet, reproductive status and housing condition on the amounts of 25(OH) vitamin D in the serum of healthy dogs: Reference values
Authors: Alizadeh Kimia , Ahmadi Saba , Sarchahi Ali Asghar , Mohri Mehrdad 
Published: September 2022

AbstractBackgroundOptimal amount of vitamin D for the proper functioning of the immune system is different from the required vitamin D amount for bones to prevent rickets. However, reports on vitamin D reference values in dogs are minimal, and there is still not enough information regarding the relationship between vitamin D and various variables such as disease, age, breed, diet type, and so on, as well as its relationship with haematological and serum biochemical parameters.ObgectivesThe present study aimed to determine reference values of 25(OH) Vit D in dogs and its concentration in different groups, categorized based on age, sex, breed, housing conditions, and diet, as well as 25(OH) Vit D relationship with hematology and serum biochemistry parameters.MethodsIn this study, 90 healthy dogs were selected to determine the reference value of 25 (OH) Vit D of serum after evaluating of their haematological and biochemical parameters to assess their general health. Dogs were divided into different groups according to above‐mentioned variables. Serum 25 (OH) Vit D was subsequently measured by the ELISA method.ResultsThe median concentration of 25 (OH) Vit D was 52.50 ng/ml with minimum and maximum amounts of 14.00 and 155.57 ng/ml, respectively. No significant difference was observed between 25 (OH) Vit D levels in the studied dogs regarding their different age, sex, breed, diet, housing condition, and reproductive status. Serum 25 (OH) Vit D concentration is directly correlated with the number of band neutrophils (p < 0.05). We also witnessed indirect correlations between serum 25 (OH) Vit D levels and the number of blood eosinophils and serum glucose (p < 0.05).ConclusionIn the present study age, sex, breed, housing condition and age had no significant effects on the amounts of 25(OH) vitamin D. According to correlations of vitamin D with MCH, band and eosinophil numbers and glucose, vitamin D may have a role in erythropoiesis and leukocytes response and also in energy metabolism in dog.
Long duration anaesthesia in pigs with an infusion of alfaxalone and dexmedetomidine
Authors: Kat Irving , Ahern Benjamin J. , Dhanani Jayesh , Whitten Grant , Cowling Nicholas , Goodwin Wendy 
Published: September 2022

AbstractPigs are commonly maintained on total intravenous anaesthesia when used in comparative medical research to study controlled manual ventilation of the lung. In this case study, four pigs were anaesthetised with a total intravenous anaesthetic infusion of alfaxalone and dexmedetomidine for up to 24 h whilst being mechanically ventilated. Cardiovascular parameters, blood gas values and body temperature were minimally affected throughout the anaesthetic period. Additional analgesia is recommended when utilising this drug combination for procedures that involve noxious stimuli.
Insights into established and emerging roles of SR protein family in plants and animals
Authors: Kumar Kundan , Sinha Shubham Kumar , Maity Upasana , Kirti Pulugurtha Bharadwaja , Kumar Koppolu Raja Rajesh 
Published: September 2022

AbstractSplicing of pre‐mRNA is an essential part of eukaryotic gene expression. Serine‐/arginine‐rich (SR) proteins are highly conserved RNA‐binding proteins present in all metazoans and plants. SR proteins are involved in constitutive and alternative splicing, thereby regulating the transcriptome and proteome diversity in the organism. In addition to their role in splicing, SR proteins are also involved in mRNA export, nonsense‐mediated mRNA decay, mRNA stability, and translation. Due to their pivotal roles in mRNA metabolism, SR proteins play essential roles in normal growth and development. Hence, any misregulation of this set of proteins causes developmental defects in both plants and animals. SR proteins from the animal kingdom are extensively studied for their canonical and noncanonical functions. Compared with the animal kingdom, plant genomes harbor more SR protein‐encoding genes and greater diversity of SR proteins, which are probably evolved for plant‐specific functions. Evidence from both plants and animals confirms the essential role of SR proteins as regulators of gene expression influencing cellular processes, developmental stages, and disease conditions.This article is categorized under:
RNA Processing > Splicing Mechanisms
RNA Processing > Splicing Regulation/Alternative Splicing
In silico modeling for the hepatic circulation and transport: From the liver organ to lobules
Authors: Ho Harvey , Means Shawn , Safaei Soroush , Hunter Peter John 
Published: September 2022

AbstractThe function of the liver depends critically on its blood supply. Numerous in silico models have been developed to study various aspects of the hepatic circulation, including not only the macro‐hemodynamics at the organ level, but also the microcirculation at the lobular level. In addition, computational models of blood flow and bile flow have been used to study the transport, metabolism, and clearance of drugs in pharmacokinetic studies. These in silico models aim to provide insights into the liver organ function under both healthy and diseased states, and to assist quantitative analysis for surgical planning and postsurgery treatment. The purpose of this review is to provide an update on state‐of‐the‐art in silico models of the hepatic circulation and transport processes. We introduce the numerical methods and the physiological background of these models. We also discuss multiscale frameworks that have been proposed for the liver, and their linkage with the large context of systems biology, systems pharmacology, and the Physiome project.This article is categorized under:
Metabolic Diseases > Computational Models
Metabolic Diseases > Biomedical Engineering
Cardiovascular Diseases > Computational Models
Real-Time Visualization of Stream-Based Monitoring Data
Authors: Baumeister Jan , Finkbeiner Bernd , Gumhold Stefan , Schledjewski Malte 
Published: September 2022

AbstractStream-based runtime monitors are used in safety-critical applications such as Unmanned Aerial Systems (UAS) to compute comprehensive statistics and logical assessments of system health that provide the human operator with critical information in hand-over situations. In such applications, a visual display of the monitoring data can be much more helpful than the textual alerts provided by a more traditional user interface. This visualization requires extensive real-time data processing, which includes the synchronization of data from different streams, filtering and aggregation, and priorization and management of user attention. We present a visualization approach for theRTLolamonitoring framework. Our approach is based on the principle that the necessary data processing is the responsibility of the monitor itself, rather than the responsibility of some external visualization tool. We show how the various aspects of the data transformation can be described asRTLolastream equations and linked to the visualization component through a bidirectional synchronous interface. In our experience, this approach leads to highly informative visualizations as well as to understandable and easily maintainable monitoring code.
DRUCKVORLAGE: DAS INSTRUMENT IBUT-CMA IN (ANLEHNUNG AN) LEICHTER SPRACHE
Authors: Muth Lydia 
Published: September 2022

ZusammenfassungDas „IBUT-CMA in Anlehnung an leichte Sprache“ ist in Inhalt, Aufbau und Aussehen identisch mit dem originalen „IBUT-CMA“. Es ist, um Barrieren zu überwinden und die Mitwirkung der Klientel zu erhöhen, in größerer Schrift und in vereinfachter Sprache formuliert. Das Instrument ist im Querformat erstellt, sodass eine Seite des „IBUT-CMA in Anlehnung an leichte Sprache“ eine halbe Seite des originalen „IBUT-CMA“ darstellt. Daraus ergibt sich, dass zwei Bögen (quasi als DIN A3) übereinander gelegt stets den Bogen des originalen „IBUT-CMA“ (in DIN A4) abbilden. Somit können alle am Erfassungsprozess Beteiligten die für sie angenehmere Version des IBUT-CMA (Original oder in Anlehnung an leichte Sprache) gleichzeitig verwenden und stets nachvollziehen, an welcher Stelle sich das Gegenüber jeweils befindet. Dies ist wichtig, um der Klientel Vertrauen in den Prozess zu ermöglichen, damit sie selbstbestimmter an der Bedarfserfassung mitwirkt und mitwirken kann.
BASTELBOGEN: DAS TEILHABE-WINDRAD
Authors: Muth Lydia 
Published: September 2022

ZusammenfassungTeilhabe als Begriff wird in Kapitel 2.4.4 wie folgt definiert: Der Begriff der sozialen Teilhabe als Zielkonstrukt institutioneller Hilfen beschreibt das individuell optimale Verhältnis aus den, in höchstmöglichem Maß, anzustrebenden Faktoren ‚Selbstbestimmtheit‘, ‚Einbezogensein in die Lebenssituation‘, ‚Lebensqualität‘ und ‚Lebenszufriedenheit‘. In vielen Situationen ist eine Definition jedoch zu abstrakt um den Inhalt vollständig zu begreifen. Das Teilhabe-Windrad hilft in gebastelter Form die Komplexität des Teilhabe-Begriffes auch der Klientel selbst verständlich zu machen. Es zeigt, dass nur dann „Schwung“ in die Teilhabeförderung kommt, wenn alle vier Faktoren gleichermaßen Beachtung finden. Lässt man einen Aspekt weg (Flügel abschneiden) oder konzentriert sich nur auf einen oder zwei (vergrößern/ etwas ankleben), „läuft es einfach nicht mehr rund“. Eine Version in leichter Sprache ist beigefügt.
Methodisches Vorgehen
Authors: Muth Lydia 
Published: September 2022

ZusammenfassungKapitel sechs befasst sich mit dem methodischen Vorgehen der Arbeit. Hierzu werden zu Beginn die Datenschutzrichtlinien, welche für die Arbeit relevant sind, vorgestellt. Im Hauptteil dieses Kapitels wird eine schematische Übersicht gegeben, welche die durchgeführten Studien in Ziel und Umfang herausstellt. Anschließend werden die einzelnen methodischen Verfahren begründet, in ihrer Durchführung beschrieben sowie die gewonnen Daten dargestellt und interpretiert.
Ergebnisse
Authors: Muth Lydia 
Published: September 2022

ZusammenfassungDas siebente Kapitel fasst alle Ergebnisse der vorliegenden Arbeit einzeln zusammen. Neben der Beantwortung der Forschungsfragen werden hierbei vor allem folgende genannt und noch einmal kurz erörtert:

das IBUT-CMA als Bedarfserfassungsinstrument

Teilhabe – eine Begriffsdefinition als dynamisches Modell

Merkmale einer arbeitsähnlichen Tätigkeit

Kausalkette der Bedarfserfassung

Eruierung der Therapieverlaufskategorien und der Leistungsstufen für CMA

Modell der Beeinträchtigung und Förderung der Teilhabe für CMA (MBFT)

Im Anschluss wird der Einfluss der Erkenntnisse auf den Paradigmenwechsel kurz diskutiert.
DRUCKVORLAGE: DAS INSTRUMENT IBUT-CMA
Authors: Muth Lydia 
Published: September 2022

ZusammenfassungDas Instrument zur Bedarfserfassung und Teilhabesicherung für Chronisch Mehrfachgeschädigt/Mehrfachbeeinträchtigt Abhängigkeitskranke (IBUT-CMA) ist ein ganzheitliches Instrument zur personenzentrierten Bedarfserfassung auf Grundlage der ICF. Es ermöglicht die Ziele und Bedürfnisse der Klientel aktiv mit den CMA-Betroffenen in Leistungen der Eingliederungshilfe zur Förderung der Teilhabe zu überführen. Auch die Mitwirkungsmöglichkeit und Teilhabe der Klientel während des Bedarfserfassungsprozesses wird durch das IBUT-CMA verbessert. Das beiliegende Manual enthält Situationshilfen um dem Erfassenden Unterstützung und mehr Sicherheit zu geben. Des Weiteren fördert das IBUT-CMA eine klare Kommunikationsstruktur zwischen Kostenträger und Leistungserbringer. Es ermöglicht eine praxisnahe, transparente und leistungsgerechte direkte monetäre Abbildung der Hilfen als Fachleistungsstunden oder Gesamtfinanzierungsbedarf.
Shaping the Field of Open, Distance, and Digital Education
Authors: Zawacki-Richter Olaf , Jung Insung 
Published: September 2022

AbstractThis chapter provides a brief overview of the overall structure by the Chief Editors of the Handbook of Open, Distance, and Digital Education (ODDE) published in Springer’s Major Reference Series. The handbook is organized along the lines of the 3M-Framework covering all important issues related to ODDE at the macro- (ODDE systems, theories, and methods), meso- (ODDE educational management and institutions), and micro- (teaching and learning) levels. Each level is addressed in one volume with two sections. Informed by the historical roots of ODDE, the editors and authors of this handbook are shaping the field of ODDE scholarship, theory, and practice.
M5 branes on ℝ1,1×Taub-NUT
Authors: Gustavsson Andreas 
Published: September 2022

Abstract
We study M5 branes on ℝ1,1×Taub-NUT that we view as a singular fibration. Reducing the M5 branes along the fiber gives 5d SYM. Due to the singularity, this 5d theory has a gauge anomaly and it is not supersymmetric. To cure these problems we add a supersymmetric gauged chiral WZW theory on the 2d submanifold where the circle fiber vanishes. In addition we add a mass term for the five scalar fields located on this submanifold. With all this, we obtain a fully supersymmetric and gauge invariant theory.
Causality, unitarity and stability in quantum gravity: a non-perturbative perspective
Authors: Platania Alessia 
Published: September 2022

Abstract
Resumming quantum fluctuations at the level of the gravitational path integral is expected to result in non-local effective actions and thus in a non-trivial momentum dependence of the propagator. Which properties the (dressed) graviton propagator has to satisfy and whether they can all be met are key open questions. In this work we present criteria and conditions for the momentum dependence of a graviton propagator which is consistent with unitarity, causality, and stability in a non-perturbative setting. To this end, we revisit several aspects of these conditions, highlighting some caveats and subtleties that got lost in recent discussions, and spelling out others that to our best knowledge have not been studied in detail. We discuss the consequences of these concepts for the properties of the graviton propagator. Finally, we provide examples of propagators satisfying unitarity and causality, while avoiding tachyonic and vacuum instabilities, and allowing for an analytic Wick rotation.
Light-front approach to axial-vector quarkonium γ*γ* form factors
Authors: Babiarz Izabela , Pasechnik Roman , Schäfer Wolfgang , Szczurek Antoni 
Published: September 2022

Abstract
In this work, we perform a detailed study of transition form factors for axial- vector meson production via the two-photon fusion process γ*γ* → 1++, with space-like virtual photons in the initial state and a P-wave axial-vector quarkonium in the final state. In this analysis, we employ the formalism of light-front quarkonium wave functions obtained from a solution of the Schrödinger equation for a selection of interquark potentials for $$ Q\overline{Q} $$
Q

Q
¯

interaction. We found the helicity structure and covariant decomposition of the matrix elements that can be generically applied for any $$ q\overline{q} $$
q

q
¯

axial-vector meson γ*γ* → 1++ transition, while our numerical results are given for the phenomenologically relevant charmonium χc1 state. We present the helicity form factors as functions of both photon virtualities. We also obtain, that QFLT(Q2, 0)/FTT(Q2, 0) = const.