bluuebunny/crossref_metadata_2025_split huggingface dataset:
BDNF and its Role in the Alcohol Abuse Initiated During Early Adolescence: Evidence from Preclinical and Clinical Studies
Authors: Cutuli Debora , Sampedro-Piquero Piquero 
Published: June 2022

Abstract:Brain-derived neurotrophic factor (BDNF) is a crucial brain signaling protein that is integral to many signaling pathways. This neurotrophin has shown to be highly involved in brain plastic processes such as neurogenesis, synaptic plasticity, axonal growth, and neurotransmission, among others. In the first part of this review, we revise the role of BDNF in different neuroplastic processes within the central nervous system. On the other hand, its deficiency in key neural circuits is associated with the development of psychiatric disorders, including alcohol abuse disorder. Many people begin to drink alcohol during adolescence, and it seems that changes in BDNF are evident after the adolescent regularly consumes alcohol. Therefore, the second part of this manuscript addresses the involvement of BDNF during adolescent brain maturation and how this process can be negatively affected by alcohol abuse. Finally, we propose different BNDF enhancers, both behavioral and pharmacological, which should be considered in the treatment of problematic alcohol consumption initiated during the adolescence.
Comparing the Effects of a Herbal Drug based on Echium Amoenum With Fluvoxamine in the Treatment of Adolescents with Obsessive-compulsive Disorder
Authors: Abrishami Maryam Hosseini , Noras Mohamad Reza , Soltanifar Atefeh , Salari Roshanak , Jarahi Lida 
Published: June 2022

Background:Obsessive-compulsive disorder (OCD) is a severe and debilitating neuropsychiatric condition. Although selective serotonin reuptake inhibitors, tricyclic antidepressants, and cognitive- behavioral therapy are the first-line medication and treatment for OCD, an estimated 30% of patients are treatment-resistant, and complete functional recovery is rare. Natural products as adjuvant or alternative therapies should be examined to find safer and more effective ways to manage OCD.Objective:To investigate the potential benefits of a combined herbal drug based on Echium amoenum in treating OCD.Methods:Design and Setting: In the psychiatric clinics of Mashhad University of Medical Sciences, 40 patients who met the criteria for the obsessive-compulsive disorder based on DSM-5 were studied in a parallel, double-blind, randomized clinical trial.Intervention:Subjects were randomly assigned to receive Echium amoenum-Melissa officinalis syrup and fluvoxamine or placebo syrup and fluvoxamine for 8 weeks.Outcome Measures:The efficacy of treatment and recurrence of disease were surveyed and compared according to the Yale-Brown Obsessive Compulsive Scale at weeks 0, 4, and 8.Results:Evaluation at the 4th and 8th week showed no significant differences between the two groups (p-value = 0.11, p-value = 0.445, respectively). At the 8th week of treatment, patients in the intervention group showed a remarkable reduction in scores on the Yale-Brown Obsessive-Compulsive Scale questionnaire (p- value= 0.003), and patients in the control group didn’t ((p- value= 0.180). This study showed that the E.amoneum-M.officinalis syrup was not significantly more efficacious than the fluvoxamine tablet, but the intervention group showed a significant improving trend (p-value= 0.001).Conclusion:While monotherapy is usually the gold standard methodology, combination or augmentation therapy may also be of merit. Consequently, studies with larger sample sizes and the inclusion of para-clinical assessments such as serologic tests can further shed light on the mechanism of action of the E. amoneum- M. officinalis syrup and deepen our understanding of its effects.Clinical Trial Registration Number:We registered this trial in the Iranian Registry of Clinical Trials (registration ID: IRCT20191127045521N1).
Beta Thalassemia Carrier Rate: Problem Burden among High School Children
Authors: Sherief Laila M. , El-Shanshory Mohamed R. , Yahia Sohier , Ragab Seham M. , Mansour Ahmed K. , Hassab Hoda M. , Hesham Mervat A. , Ahmed Adel S. , Beshir Mohamed R. , El Fotoh Wafaa M. Abo , El Naby Sameh A. Abd , Alllah Ahmed M. Gad , Khalifa Naglaa A. , Soliman Mohamed A. , El-Dahtory Faeza , El-Farahaty Reham M. , Osman Engy , Elhabyan Abdelazeem , El-Lateef Amal E. Abd , Kamal Naglaa M. , Kabbash Ibrahim A. , Saied Shimaa M. , Eid Abdel-Rahman 
Published: June 2022

Background & Aim of the work:
β-Thalassemia (βT) is highly prevalent in some countries like Egypt. Accurate data about actual disease prevalence and heavily prevalent geographic locations are essential to help in early detection and in setting up effective preventive programs. We aim for screening of βT carriers among Egyptian high school students in the Delta region.

Subjects and Methods:
A cross-sectional multicenter study was carried on 4320 randomly selected students from four governorates of the Nile Delta region, Egypt. All patients were to be tested for their complete blood count. Those with microcytic hypochromic anemia not caused by iron deficiency were tested for βT carrier status using high-performance liquid chromatography.

Results:
The total prevalence of βT carrier rate was 6.13%. The highest prevalence was detected in Al-Sharkia Governorate, reaching 7.89%, followed by 6.90% in Al-Gharbia Governorate. Al-Dakahilia and Al-Menoufia showed lower rates of 4.86% and 3.73%, respectively.

Conclusions:
Despite the premarital national screening program for βT in Egypt, the carrier rate is still high. More effort should be done for the proper implementation of national prevention programs.
Human Umbilical Cord Mesenchymal Stem Cells' Cultivation and Treatment
of Liver Diseases
Authors: Zhu Zihe , Zhang Qianqian , Liu Lixin , Xu Jun 
Published: June 2022

Background:
Over the past few years, mesenchymal stem cells (MSCs) have been regarded as
effective for treating various diseases. Among the types of MSCs, human umbilical cord mesenchymal
stem cells (hUC-MSCs) have been widely studied because of their advantages in non-invasive damage to
donors and the wide range of sources.

Main body:
This article reviews three aspects of hUC-MSCs. Foremost are the latest advances in the
cultivation and preparation methods of hUC-MSCs. Furthermore, the treatments mechanism of hUCMSCs
in organ transplantation and liver diseases. Finally, a summary of their use in clinical trials in liver
diseases. The first part of this paper emphasizes the differences between the selection area and culture
factors, including the separation method, long-term culturing in vitro, medium composition, serum, and
three-dimensional (3D) skeleton system training, which could affect the characteristics of hUC-MSCs and
the treatment of diseases. The second section mainly stresses the mechanisms of hUC-MSCs in the treatment
of diseases, including immunoregulation and transdifferentiation into hepatocyte-like cells. Many
new technologies mark and track cells in vivo and their safety. Briefly mention its role in the treatment of
other diseases and vaccine preparation. In the third part, to accelerate the application of hUC-MSCs in the
treatment of clinical diseases, it is necessary to expand the sample size of clinical trials to ensure their
safety in the human body and determine the most effective infusion method and volume. Conclusion:
hUC-MSCs have a substantial potential to become a more effective treatment for liver diseases. Clinical
trials and mechanisms have laid the foundation for the normalization of clinical hUC-MSCs delivery.
Design, Synthesis and Biological Evaluation of Novel Quinoline Derivatives as Potential
Anti-Proliferative Agents Against PC-3 and KG-1 Cells
Authors: Zhang Wei , Ma Peizhi , Li Kun , Xu Yuanbo , Sun Jun 
Published: June 2022

Background:
Cancer is a major public health problem worldwide, and is the leading cause of death.
The discovery and development of cancer therapeutic drugs have become the most urgent measure, which significantly
benefited from the usage of small molecule compounds. The quinoline core possessed a vast number
of biological activities that were found to be imperative.

Objective:
The aim is to design, synthesize and perform the biological evaluation of novel quinoline derivatives
as potential anti-proliferative agents.

Methods:
Quinoline as a privileged scaffold was adopted to introduce diverse effective nitrogen heterocycles
through different linkers. The synthesized compounds were spectroscopically characterized and evaluated for
their anti-proliferative activity using the CCK8 assay. The mechanism of action was investigated by flow cytometry
and the inhibitory activity against Pim-1 kinase was measured by mobility shift assay. Molecular docking
analysis was performed to rationalize biochemical potency as well.

Results:
The majority of these quinolines displayed potent growth inhibitory effects, among which compounds
13e, 13f and 13h were the most effective ones, with GI50 values of 2.61/3.56, 4.73/4.88 and 4.68/2.98 μM, respectively.
Structure-activity relationships indicated that both appropriate heterocycles at the C4 position of pyridine
and suitable substituent at quinoline had a significant impact on improving activity. Compounds 13e and
24d exhibited moderate Pim-1 kinase inhibitory activity.

Conclusion:
In this study, three series of novel molecules bearing quinoline scaffold were designed, synthesized
and evaluated for their in-vitro anti-proliferative activity. The most promising candidate, 13e, caused cell cycle
arrest in a concentration-dependent manner and further induced apoptosis, which might represent a novel antiproliferative
agent working through Pim-1 kinase inhibition to a certain extent.
The Prevalence of Early Toxoplasmosis after Bone Marrow Transplantation
Using PCR: A Study in Iranian Patients
Authors: Abolghasemi Sara , Khederzadeh Sepideh , Salari Sina , Mardani Masoud , ArabMazar Zahra , Ettefaghi Mona , Kamrani Ramiz , Ghorbi Mahmoud Dehghani 
Published: June 2022

Background:
In immuno-compromised organ transplant recipients, toxoplasmosis can be
caused by either an infected graft or a latent infection, during which transformation from a chronic
state to an active infection (reactivation) is observed. PCR is an accurate and sensitive molecular
method widely used in medical sciences, especially in diagnostic procedures.

Objective:
The aim of this study was to determine the prevalence of early toxoplasmosis infection in
bone marrow transplant patients by PCR.

Methods:
The blood samples of 50 patients with hematological disorders who had received bone marrow
transplants were collected using a standard phlebotomy technique. To evaluate antitoxoplasma
antibodies, we utilized the enzyme-linked immunosorbent assay (ELISA) method using a specific
commercial kit (Akon) based on the manufacturer’s instructions. Genomic DNA extracted from toxoplasma
tachyzoite was used as the template for PCR.

Results:
22 (44%) patients were women, and 28 (56%) were men. There were no significant differences
in the distribution of genders and age groups in patients with various cancers. Antitoxoplasma
IgG was positive in 39 patients, while none of them were IgM positive.
According to PCR results, 5 patients were positive for toxoplasmosis. All of the PCR-positive cases (2
with AML, 2 with HL, and 1 with AA) had successful engraftment at 40 days post-transplantation.

Conclusion:
Because of the higher efficacy of PCR in the diagnosis of toxoplasmosis, using this method
along with other routine diagnostic modalities in this condition is recommended. PCR-based techniques
can also be utilized to periodically determine parasite load in blood after transplantation.
The Role of Soluble ACE2 as a Prognostic Marker in Severe COVID-19: A
Brief Meta-Analysis
Authors: Rahimzadeh Mahsa , Naderi Nadereh 
Published: June 2022

Background:
The recently emerged novel coronavirus, severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), has posed a serious threat to public health, and there is an
urgent need to establish tools that can aid the clinician in the evaluation and management of highrisk
patients. This meta-analysis aimed to investigate the potential of sACE2 (soluble angiotensinconverting
enzyme 2) as a prognostic biomarker in COVID-19.

Method:
A comprehensive search of PubMed/MEDLINE, Cochrane, and Google Scholar, was
performed until May 26, 2021. Data extraction and quality assessment of the study were independently
conducted by the authors. Finally, 6 studies were included in this meta-analysis.

Results:
ACE-2 serum or plasma levels were compared between COVID-19 patients and healthy
controls. ACE-2 level was not significantly different between severe COVID-19 patients and
healthy controls (SMD = 1.2; 95% CI: -1.3-1.5; P = 0.86), severe and non-severe COVID-19 patients
(SMD = 0.3; 95% CI: -0.06-0.7; P = 0.1), and severe COVID-19 patients and healthy controls
(SMD = 0.6; 95% CI: -1.1-2.3; P = 0.5).

Conclusions:
We cautiously propose that circulating levels of ACE2 cannot be used as a biomarker
to assess disease severity in COVID-19 patients.
FUNCTIONAL CAPACITY and quality of life IN CHILDREN AND ADOLESCENTS WITH SICkLE CELL ANEMIA
Authors: Silva Jonathan Luiz da , Soares Bruno Alvarenga , Silva Jaksoel , Blum Patrícia Belintani , Reimberg Mariana Mazzuca , Corso Simone Dal , Lanza Fernanda 
Published: June 2022

Objective: To evaluate the functional capacity, pulmonary
function and quality of life of children and adolescents with sickle
cell anemia (SCA) and to test the reproducibility of functional capacity
tests in this population. Method: Cross-sectional study with
volunteers with SCA genotype Hb-SS (SCAG), aged 6 to 18 years matched
in age and gender to the control group (CG). Spirometry, 5-repetition
sit-to-stand test (5STS-test), modified shuttle walk test (MSWT), and
Pediatric Quality of Life Questionnaire (PedsQL) were performed. The
reproducibility of 5STS-test and MSWT was evaluated: Results:
48 volunteers of SCAG and 48 of CG were evaluated. Pulmonary function of
SCAG (FVC: 92 ± 15% pred.; FEV 1 /FVC: 84 ± 8% pred.) was worse than
the CG (104 ± 15% pred.; FEV 1 /FVC: 90 ± 6% pred.) p <
0.05. SCAG had worse functional capacity registered by distance walked:
576m (515-672m) and 5STS-test: 8 seconds (7.4-8.9seconds) compared to
the CG who showed distance walked: 1010m (887- 1219m) and 5STS-test: 7
seconds (7.0-8.1seconds), p < 0.001. SCAG had worse quality
compared to CG, p < 0.05. The reproducibility was good of MSWT
(ICC 0.99 (0.98-0.99 IC-95%)) and 5STS-test (ICC 0.80 (0.69 – 0.88), p
< 0.001 . Conclusion: Children and adolescents with
sickle cell anemia showed worse capacity to walk or run, and to perform
sit-to-stand test. Additionally, they have poor quality of life when
compared with their control peers. The MSWT and 5STS-test showed
reproducible to be applied in pediatric individual with SCA.
PENANGGULANGAN ANARKISME SUPORTER MELALUI KEBIJAKAN HUKUM PIDANA (STUDI KASUS PERSIB BANDUNG DAN PERSIJA JAKARTA)
Authors: Astuti Laras , Purwanto Heri 
Published: June 2022

ABSTRAK
Anarkisme suporter sebagai salah satu permasalahan klasik dalam penyelenggaraan liga sepakbola di Indonesia akan terus terjadi di setiap tahunnya, apabila tidak ada pola penyelesaian yang baik. Terakhir, anarkisme tersebut menewaskan suporter Persija Jakarta (Haringga Sirila) dalam pertandingan antara Persija Jakarta dan Persib Bandung di Stadion Gelora Bandung Lautan Api. Penanggulangan anarkisme suporter perlu dilakukan dengan serius agar tidak ada lagi suporter yang menjadi korban. Salah satu upaya yang dapat dilakukan dengan menggunakan kebijakan hukum pidana dalam menanggulangi anarkisme supporter. Tulisan ini merupakan hasil penelitian normatif dengan didasarkan pada inventarisasi dan identifikasi data sekunder secara deskriptif kualitatif melalui pendekatan analisis kasus. Berdasarkan hasil penelitian, penanggulangan anarkisme suporter dapat dilihat dari dua pendekatan. Pertama, upaya penal mengedepankan penghukuman kepada terdakwa pengeroyokan Haringga Sirila, tiga belas orang divonis penjara sedangkan satu orang di vonis bebas. Kedua, upaya non penal mengedepankan proses pencegahan dengan mengidentifikasi faktor penyebab terjadinya anarkisme suporter yang dapat dilakukan dengan kebijakan penanaman nilai-nilai sportivitas dan fairplay serta pembinaan suporter.
Kata kunci: anarkisme; hukum pidana; kebijakan; suporter.

ABSTRACT
Anarchism of supporters as one of the classic problems in organizing the football league in Indonesia which always occurs every year if it is not resolved properly. Latest, anarchism caused the death of Persija Jakarta supporters (Haringga Sirila) in a match between Persija Jakarta and Persib Bandung at the Gelora Bandung Lautan Api Stadium. Resolving anarchism of supporters needs to be taken seriously, so that no more supporters become victims. Criminal law policy can be used as an alternative in resolving anarchism of supporters. This paper is the result of normative research based on an inventory and identification of secondary data in a descriptive qualitative manner through a case analysis approach. Based on the research results, the resolving anarchism of supporters can be seen from two approaches. First, the penal approaches made the conviction of the defendant beatings Haringga Sirila, thirteen people were sentenced to prison while one person was sentenced to be acquitted. Non-penal approaches to prioritize the prevention process by identifying the factors causing the occurrence anarchism of supporters which can be carried out with a policy of forming the values of sportsmanship, fair play, and as well as fostering supporters.
Keywords: anarchism; criminal law; policy; supporters.
PENGAKUAN PUTUSAN PENYEDIA LAYANAN PENYELESAIAN SENGKETA NAMA DOMAIN ASING
Authors: Hassanah Hetty , Wahyudi Wahyudi 
Published: June 2022

ABSTRAK
Pendaftaran dan putusan merupakan dasar hukum terbitnaya nama domain. Dalam Undang-Undang ITE hanya mengakui eksistensi Nama Domain (ND) hasil pendaftaran pada Registrar Asing (Ps. 24 ayat 3). Teknologi informasi membuka ruang baru yang dinamakan cyberspace. Nama domain termasuk dalam cyberspace yang kepentingannya melibatkan seluruh pengguna internet akan tetapi tidak semua negara mempunyai regulasi yang sesuai dengan perkembangan teori dunia maya. Metode yuridis normatif yang digunakan dalam penelitian ini dengan spesifikasi yang bersifat deskriptif analitis. Teori “Code” atau “Architecture” Lawrence Lessig dapat diterapkan terkait pengakuan dan pelaksanaan putusan penyedia layanan penyelesaian sengketa nama domain yang melibatkan pihak Warga Negara Indonesia. Konsep pengaturan hukum terkait pengakuan dan pelaksanaan putusan penyedia layanan penyelesaian sengketa nama domain asing di Indonesia, adalah yang mampu mengikuti perkembangan best practices pada masyarakat TIK terkait kepemilikan nama domain berikut sistem penyelesaian sengketa secara online yang diatur oleh ICANN dalam UDRP dan dalam Perjanjian Registri dan Perjanjian Registrar sesuai dengan teori “Code” atau “Architecture” dari Lawrence lessig.
Kata kunci: putusan arbitrase asing; nama domain; sengketa kepemilikan

ABSTRACT
Registration and sentence are the legal basis for issuing domain names. In the ITE Law, it only recognizes the existence of domain names as a result of registration at the Foreign Registrar (Art. 24 paragraph 3). Domain names are included in cyberspace whose interests involve all internet users but not all countries have regulations that are in accordance with the development of cyber theory. juridical normative used in this research with descriptive analytical specifications. Lawrence Lessig's "Code" or "Architecture" theory can be applied regarding the recognition and implementation of decisions of domain name dispute resolution service providers involving Indonesian citizens. The concept of legal arrangements related to recognition andimplementation of decisions of foreign domain name dispute resolution service providers in Indonesia, are those that are able to follow the development of best practices in the ICT community related to domain name ownership and the online dispute resolution system regulated by ICANN in the UDRP and in the Registry Agreement and Registrar Agreement in accordance with the theory of "Code Or “Architecture” by Lawrence lessig.
Keywords: foreign arbitration judgement; domain name; ownership disputes
KONSEP PENYELESAIAN PERSELISIHAN HUBUNGAN INDUSTRIAL ANTARA SERIKAT PEKERJA DENGAN PERUSAHAAN MELALUI COMBINED PROCESS (MED-ARBITRASE)
Authors: Mantili Rai 
Published: June 2022

ABSTRAK
Serikat pekerja memiliki peranan yang sangat penting bagi pekerja, pengusaha maupun serikat pekerja itu sendiri dalam proses penyelesaian perselisihan hubungan industrial. Proses penyelesaian perselisihan hubungan industrial berdasarkan Undang-Undang Nomor 2 Tahun 2004 tentang Penyelesaian Perselisihan Hubungan Industrial adalah melalui Bipartit, Tripatrit (mediasi hubungan industrial, konsiliasi hubungan industrial dan arbitrase hubungan industrial) kemudian ke Pengadilan Hubungan Industrial apabila upaya hukum non litigasi (kecuali arbitrase) tersebut tidak tercapai. Konsep combined process (med-arb) dianggap dapat memfasilitasi penyelesaian sengketa dalam perselisihan hubungan industrial karena konsep ini sudah dilakukan dalam sengketa bisnis dan dianggap lebih efektif. Penelitian ini memuat dua permasalahan yakni, mengenai konsep combined process (med-arb) yang diterapkan dalam penyelesaian perselisihan hubungan industrial antara serikat pekerja dan pengusaha dan konsep kepastian hukum penyelesaian perselisihan hubungan industrial antara serikat pekerja dan pengusaha melalui combined process (med-arb). Hasil penelitian menunjukkan bahwa konsep combined process (med-arb) dapat diterapkan dalam penyelesaian perselisihan hubungan industrial antara serikat pekerja dan pengusaha guna memberi efektifitas waktu dalam penyelesaian sengketa dan penerapan kepastian hukum.
Kata kunci: combined process (med-arb); penyelesaian sengketa; serikat pekerja.

ABSTRACT
The labor union holds important role for the employee, the company and for the labor union itself in relation with settlement of the industrial relation dispute. The processes of the industrial relation dispute settlement pursuant to Law No. 2 Year of 2004 re: Settlement of the Industrial Relation Dispute are through bipartite (bilateral), tripartite (mediation, conciliation, arbitration), and through the Industrial Relation Court if the settlement through the foregoing non-litigation process is not achieved. The concept of Combined Process (med-arb) is considered to facilitate the industrial dispute settlement due to the effective practises of such concept in business dispute.This research consist of two legal issues, namely, first, the concept of Combined Process (med-arb) which is applied in the industrial relation dispute settlement between the labor union and the company, second, the concept of certainty of law in industrial relation dispute settlement between the employee and the company through the Combined Process (med-arb). The result of this research is, the concept of Combined Process (med-arb) is applicable in the settlement of industrial relation dispute between the labor union and the company to provide the effectiveness of timeframe in the dispute settlement and the implementation of legal certainty.
Keywords: combined process; dispute settlement; labour union.