bluuebunny/crossref_metadata_2025_split huggingface dataset:
How employees resist ICT-induced organizational change? Insights from “Up in the Air”
Authors: Gūğerçin Utku 
Published: June 2022

PurposeThe purpose of this study is to explore how change recipients emotionally resist information and communication technology (ICT)-induced organizational change in practice stage-by-stage.Design/methodology/approachFollowing a qualitative case study methodology, this paper integrates Kübler-Ross grief model into a hypothetical change initiative in a critically acclaimed feature film, Up in the Air. The unit of analysis is the main character, Ryan Bingham. As a change recipient, Bingham's emotional reactions are analyzed stage-by-stage.FindingsThe study concludes that emotional resistance to ICT-induced organizational change progresses through the five stages in line with Kübler-Ross model. Even though the focus in Kübler-Ross model is on death and dying, the stages in the model are remarkably similar to the reactions of a change recipient. It is also found that the film is an appropriate instrument to demonstrate the complicated reality and intricate details of resistance, providing abundant content for the analysis of psychological components of resistance.Practical implicationsThe exploration of stages of emotional resistance may act as a guideline for leaders to follow throughout a change process. The study is expected to prepare the leaders for the reactions of change recipients so that they can deliver strong leadership throughout periods of change.Originality/valueThe originality of the study lies in the fact that it provides an opportunity to advance the understanding of the abstract concept of resistance, bridges the widely-discussed research-practice gap and analyze emotional resistance stage-by-stage by integrating Kübler-Ross model to a hypothetical change initiative.
Tech and the times: why technology is the double-edged sword that HR teams must navigate
Authors: Latus Jack 
Published: June 2022

Purpose
This study aims to explore how changing technology can be harnessed by HR teams to improve the efficiency of the workplace and elevate the employee experience. It analyses whether technology contributes to more issues than it solves, and whether HR teams should consider adopting measures grounded in technology.

Design/methodology/approach
This study stemmed from the recent publishing of the Chartered Institute of Personnel and Development employee well-being report and months of research into the key issues that HR teams face within the industry, offering a perspective on why they should consider technology as the solution to these.

Findings
By adapting HR strategy, technology can be used to better employee health and well-being, as well as business turnover. The future of HR doesn’t lie in rejecting these new systems and ways of working, but rather by accepting them and implementing the necessary boundaries to preserve and even improve employee health.

Originality/value
The value of this study is to provide HR teams with a comprehensive take on the role that technology currently plays, and will continue to play, as a solution to the issues that plague the industry.
Organic matter availability drives the spatial variation in the community composition and activity of Antarctic marine bacterioplankton
Authors: Piontek Judith , Meeske Christian , Hassenrück Christiane , Engel Anja , Jürgens Klaus 
Published: June 2022

SummaryCarbon cycling by Antarctic microbial plankton is poorly understood but it plays a major role in CO2 sequestration in the Southern Ocean. We investigated the summer bacterioplankton community in the largely understudied Weddell Sea, applying Illumina amplicon sequencing, measurements of bacterial production and chemical analyses of organic matter. The results revealed that the patchy distribution of productive coastal polynyas and less productive, mostly ice‐covered sites was the major driver of the spatial changes in the taxonomic composition and activity of bacterioplankton. Gradients in organic matter availability induced by phytoplankton blooms were reflected in the concentrations and composition of dissolved carbohydrates and proteins. Bacterial production at bloom stations was, on average, 2.7 times higher than at less productive sites. Abundant bloom‐responsive lineages were predominately affiliated with ubiquitous marine taxa, including Polaribacter, Yoonia‐Loktanella, Sulfitobacter, the SAR92 clade, and Ulvibacter, suggesting a widespread genetic potential for adaptation to sub‐zero seawater temperatures. A co‐occurrence network analysis showed that dominant taxa at stations with low phytoplankton productivity were highly connected, indicating beneficial interactions. Overall, our study demonstrates that heterotrophic bacterial communities along Weddell Sea ice shelves were primarily constrained by the availability of labile organic matter rather than low seawater temperature.
ShoTS Forecasting: Short Time Series Forecasting for Management Research
Authors: Thomakos Dimitrios , Wood Geoffrey , Ioakimidis Marilou , Papagiannakis Giorgos 
Published: June 2022

AbstractWe present a novel method for forecasting with limited information, that is for forecasting short time series. Our method is simple and intuitive; it relates to the most fundamental forecasting benchmark and is straightforward to implement. We present the technical details of the method and explain the nuances of how it works via two illustrative examples, with the use of employment‐related data. We find that our new method outperforms standard forecasting methods and thus offers considerable utility in applied management research. The implications of our findings suggest that forecasting short time series, of which one can find many examples in business and management, is viable and can be of considerable practical help for both research and practice – even when the information available to analysts and decision‐makers is limited.
The effect of packaging and storage time on quality of clustered fresh pistachio
Authors: Tajeddin Behjat , Shakerardekani Ahmad 
Published: June 2022

AbstractPistachio is one of the valuable, very nutritious, and high‐energy fruits that is mainly dried and used as a snack due to problems with storage. Therefore, to investigate on how to extend clustered fresh pistachios’ shelf‐life, the effects of various packaging and storage conditions on the pistachios are presented in this study. Thus, clustered in‐hull fresh pistachios were packaged in: (a) Polyethylene film, 45 µm in thickness; (b) polypropylene/polyethylene/polyamide/polyethylene/aluminum foil multilayer film, 90 µm in thickness; (c) both films with alcoholic paper; in air, and under two gas mixtures of 88%N2 + 10%CO2 + 2%O2 and 83%N2 + 15%CO2 + 2%O2. Samples were refrigerated at 5 ± 1°C for 3 months. Quality factors such as moisture content, weight loss, respiration rate, pH, texture, and appearance of the samples were monitored for fresh pistachio kernels and clustered pistachios. Data were analyzed in a completely randomized design using one‐way analysis of variance. The results showed that the shelf‐life of MAP samples drastically increased compared to the control (packages without gaseous and alcoholic paper). A comparison of means among the groups suggests that the multilayer bags of fresh clustered pistachios with a mixture of 83%N2 + 15%CO2 + 2%O2 for a 3‐month storage period is a particularly effective treatment.Practical ApplicationIt is the first time that fresh pistachio is packaged in clusters (bundle). It seems that the packaging of fresh pistachio clusters, in addition to the benefits mentioned in this paper has a psychological effect on the consumer in terms of the naturalness of this product and has added value due to being considered an organic, luxurious, and delicacy food product. Therefore, in this study, the active MAP method that includes the technique of injecting carbon dioxide, nitrogen, and oxygen into the packaging was used to investigate its effects on the properties and shelf‐life of raw clustered pistachios for fresh consumption.
Avoiding entry into intracellular protein degradation pathways by signal mutations increases protein secretion in Pichia pastoris
Authors: Ito Yoichiro , Ishigami Misa , Hashiba Noriko , Nakamura Yasuyuki , Terai Goro , Hasunuma Tomohisa , Ishii Jun , Kondo Akihiko 
Published: June 2022

SummaryIn our previous study, we serendipitously discovered that protein secretion in the methylotrophic yeast Pichia pastoris is enhanced by a mutation (V50A) in the mating factor alpha (MFα) prepro‐leader signal derived from Saccharomyces cerevisiae. In the present study, we investigated 20 single‐amino‐acid substitutions, including V50A, located within the MFα signal peptide, indicating that V50A and several single mutations alone provided significant increase in production of the secreted proteins. In addition to hydrophobicity index analysis, both an unfolded protein response (UPR) biosensor analysis and a microscopic observation showed a clear difference on the levels of UPR induction and mis‐sorting of secretory protein into vacuoles among the wild‐type and mutated MFα signal peptides. This work demonstrates the importance of avoiding entry of secretory proteins into the intracellular protein degradation pathways, an observation that is expected to contribute to the engineering of strains with increased production of recombinant secreted proteins.
Genetic sampling and an activity index indicate contrasting outcomes of lethal control for an invasive predator
Authors: Le Pla Mark N. , Birnbaum Emma K. , Rees Matthew W. , Hradsky Bronwyn A. , Weeks Andrew R. , Van Rooyen Anthony , Pascoe Jack H. 
Published: June 2022

ABSTRACTInvasive mammalian predators are implicated in the ongoing decline of a suite of fauna and continue to be a major cause of human–wildlife conflict globally. Lethal control of invasive predators is a common management strategy; however, the use of activity indices to measure management effectiveness is problematic. Non‐invasive genetic sampling may be a viable alternative approach to monitoring as individual animals can be identified, allowing for direct estimation of population density through newly developed spatially explicit capture–recapture techniques. Here we compare inferences derived from a basic activity index (number of scats per survey) and genetic sampling of scats within a before–after control–impact design to evaluate the effectiveness of a lethal control programme targeting red foxes (Vulpes vulpes) in south‐eastern Australia. The activity index was highly variable through time and suggested the baiting programme reduced fox activity on the treatment transect relative to changes on the non‐treatment transect. In contrast, genetic sampling and spatially explicit capture–recapture analysis suggested fox density varied little throughout the study, with any changes unable to be attributed to the baiting programme. Additionally, genetic sampling confirmed many individuals persisted through 7 months of baiting. These contrasting results may be partially explained by changes in scat detectability due to seasonal changes in behaviour and the disproportionate contribution of some individuals to scat counts. Our pre‐baiting density estimate of 0.28 foxes km2 (95% CI: 0.22–0.38) was lower than expected given the high productivity, abundant prey species and lack of larger predators in the study region. Our results highlight the need for cautious interpretation of activity indices and demonstrates the value of incorporating recent methodological and statistical advances when evaluating lethal control programmes.
SARS‐CoV‐2 transmission risk to healthcare workers performing tracheostomies: a systematic review
Authors: Subramaniam Ashwin , Lim Zheng Jie , Ponnapa Reddy Mallikarjuna , Mitchell Hayden , Shekar Kiran 
Published: June 2022

AbstractBackgroundTracheostomy is a commonly performed procedure in patients with coronavirus disease 2019 (COVID‐19) receiving mechanical ventilation (MV). This review aims to investigate the occurrence of SARS‐CoV‐2 transmission from patients to healthcare workers (HCWs) when tracheostomies are performed.MethodsThis systematic review used the preferred reporting items for systematic reviews and meta‐analysis framework. Studies reporting SARS‐CoV‐2 infection in HCWs involved in tracheostomy procedures were included.ResultsSixty‐nine studies (between 01/11/2019 and 16/01/2022) reporting 3117 tracheostomy events were included, 45.9% (1430/3117) were performed surgically. The mean time from MV initiation to tracheostomy was 16.7 ± 7.9 days. Location of tracheostomy, personal protective equipment used, and anaesthesia technique varied between studies. The mean procedure duration was 14.1 ± 7.5 minutes; was statistically longer for percutaneous tracheostomies compared with surgical tracheostomies (mean duration 17.5 ± 7.0 versus 15.5 ± 5.6 minutes, p = 0.02). Across 5 out of 69 studies that reported 311 tracheostomies, 34 HCWs tested positive for SARS‐CoV‐2 and 23/34 (67.6%) were associated with percutaneous tracheostomies.ConclusionsIn this systematic review we found that SARS‐CoV‐2 transmission to HCWs performing or assisting with a tracheostomy procedure appeared to be low, with all reported transmissions occurring in 2020, prior to vaccinations and more recent strains of SARS‐CoV‐2. Transmissions may be higher with percutaneous tracheostomies. However, an accurate estimation of infection risk was not possible in the absence of the actual number of HCWs exposed to the risk during the procedure and the inability to control for multiple confounders related to variable timing, technique, and infection control practices.
Prone ex vivo lung perfusion protects human lungs from reperfusion injury
Authors: Niikawa Hiromichi , Okamoto Toshihiro , Ayyat Kamal S. , Itoda Yoshifumi , Sakanoue Ichiro , Farver Carol F. , Yun James J. , McCurry Kenneth R. 
Published: June 2022

AbstractBackgroundWe previously reported beneficial effects of prone positioning during ex vivo lung perfusion (EVLP) using porcine lungs. In this study, we sought to determine if prone positioning during EVLP was beneficial in human donor lungs rejected for clinical use.MethodsHuman double lung blocs were randomized to prone EVLP (n = 5) or supine EVLP (n = 5). Following 16 h of cold storage at 4°C and 2 h of cellular EVLP in either the prone or supine position. Lung function, compliance, and weight were evaluated and transplant suitability determined after 2 h of EVLP.ResultsHuman lungs treated with prone EVLP had significantly higher partial pressure of oxygen/fraction of inspired oxygen (P/F) ratio [348 (291–402) vs. 199 (191–257) mm Hg, p = 0.022] and significantly lower lung weight [926(864–1078) vs. 1277(1029–1483) g, p = 0.037] after EVLP. 3/5 cases in the prone group were judged suitable for transplant after EVLP, while 0/5 cases in the supine group were suitable. When function of upper vs. lower lobes was evaluated, prone EVLP lungs showed similar P/F ratios and inflammatory cytokine levels in lower vs. upper lobes. In contrast, supine EVLP lungs showed significantly lower P/F ratios [68(59–150) vs. 467(407–515) mm Hg, p = 0.012] and higher tissue tumor necrosis factor alpha levels [100.5 (46.9–108.3) vs. 39.9 (17.0–61.0) ng/ml, p = 0.036] in lower vs. upper lobes.ConclusionsProne lung positioning during EVLP may optimize the outcome of EVLP in human donor lungs, possibly by improving lower lobe function.
Review article: diagnostic and therapeutic approach to persistent abdominal pain beyond irritable bowel syndrome
Authors: Coffin Benoit , Duboc Henri 
Published: June 2022

SummaryBackgroundPersistent abdominal pain (PAP) poses substantial challenges to patients, physicians and healthcare systems. The possible aetiologies of PAP vary widely across organ systems, which leads to extensive and repetitive diagnostic testing that often fails to provide satisfactory answers. As a result, widely recognised functional disorders of the gut–brain interaction, such as irritable bowel syndrome and functional dyspepsia, are often diagnosed in patients with PAP. However, there are a number of less well‐known differential diagnoses that deserve consideration.AimTo provide a comprehensive update on causes of PAP that are relatively rare in occurrence.MethodsA literature review on the diagnosis and management of some less well‐known causes of PAP.ResultsSpecific algorithms for the diagnostic work‐up of PAP do not exist. Instead, appropriate investigations tailored to patient medical history and physical examination findings should be made on a case‐by‐case basis. After a definitive diagnosis has been reached, some causes of PAP can be effectively treated using established approaches. Other causes are more complex and may benefit from a multidisciplinary approach involving gastroenterologists, pain specialists, psychologists and physiotherapists. This list is inclusive but not exhaustive of all the rare or less well‐known diseases potentially associated with PAP.ConclusionsPersistent abdominal pain (PAP) is a challenging condition to diagnose and treat. Many patients undergo repeated diagnostic testing and treatment, including surgery, without achieving symptom relief. Increasing physician awareness of the various causes of PAP, especially of rare diseases that are less well known, may improve patient outcomes.
Home‐based, tunnelled peritoneal drainage system as an alternative treatment option for patients with refractory ascites
Authors: Tergast Tammo L. , Griemsmann Marie , Stockhoff Lena , Heidrich Benjamin , Schirmer Hendrik , Lenzen Henrike , Wedemeyer Heiner , Cornberg Markus , Jaeckel Elmar , Maasoumy Benjamin 
Published: June 2022

SummaryBackgroundOnset of refractory ascites is the hallmark of end‐stage liver disease. If liver transplantation (LTx) is not available and contraindications for a transjugular portosystemic shunt (TIPS) are present, repeated paracentesis remains the standard of care (SOC). Home‐based, tunnelled peritoneal catheters (PeCa) have been suggested as an alternative treatment option. However, data on patients with cirrhosis are scarce.AimTo evaluate the safety of PeCa in these patients compared to SOC.MethodsOverall, 223 patients with cirrhosis, a contraindication for TIPS and refractory ascites were included in this retrospective study. PeCa implant was performed in 152 patients, whereas 71 were treated with SOC. Analysed end points included device explant‐free survival, mortality, acute kidney injury (AKI) and hyponatraemia. In the second approach, propensity score matching (PPSM) was performed to adjust for confounding factors.ResultsIn patients with PeCa, median device explant‐free survival was 74 days and 52 explants were recorded within the first 90 days. Within 90 days, patients with PeCa had lower mortality than SOC (p = 0.11), and spontaneous bacterial peritonitis (SBP) incidence did not differ (p = 0.82). Regarding AKI and hyponatraemia, there was a trend towards a higher incidence in the PeCa group (p = 0.13 and p = 0.08), and the risk for rehospitalisation was higher in those with a PeCa (HR: 2.11, p = 0.04). After PPSM, mortality was lower in the PeCa group (HR:0.40; p = 0.03), whereas the incidence of SBP and hyponatraemia was comparable (p = 0.80 and p = 0.28) and AKI was more frequent in those with a PeCa (p = 0.08).ConclusionThe implant of PeCa allows home‐based therapy of patients with cirrhosis and refractory ascites and a contraindication for TIPS. However, the risk for complications has to be considered and prospective studies are needed.
Phase 1 and preclinical profiling of ESM‐HDAC391, a myeloid‐targeted histone deacetylase inhibitor, shows enhanced pharmacology and monocytopaenia
Authors: Furze Rebecca C. , Molnar Judit , Parr Nigel J. , Ahmad Faiz , Henry Yvette , Howe David , Singh Rajendra , Toal Martin , Bassil Anna K. , Bernard Sharon G. , Davis Robert P. , Gibson Adele , Maller N. Claire , Sharp Catriona , Tough David F. , Prinjha Rab K. , Lewis Huw D. 
Published: June 2022

AimsTo improve the tolerability and therapeutic application of histone deacetylase inhibitors (HDACi), by application of an esterase‐sensitive motif (ESM), to target pharmacological activity directly to mononuclear myeloid cells expressing the processing enzyme carboxylesterase‐1 (CES1).MethodsThis first‐in‐human study comprised single and multiple ascending dose cohorts to determine safety and tolerability. Pharmacodynamic parameters included acetylation, cytokine inhibition and intracellular concentrations of processed acid metabolite in isolated monocytes. Mechanistic work was conducted in vitro and in a CES1/Es1elo mouse strain.ResultsESM‐HDAC391 showed transient systemic exposure (plasma half‐life of 21–30 min) but selective retention of processed acid for at least 12 hours, resulting in robust targeted mechanistic engagement (increased acetylation in monocytes plus inhibition of ex vivo stimulated cytokine production). ESM‐HDAC391 was well tolerated and clinical toxicities common to non‐targeted HDACi were not observed. ESM‐HDAC391 treatment was accompanied by the novel finding of a dose‐dependent monocyte depletion that was transient and reversible and which plateaued at 0.06 × 109 monocytes/L after repeat dosing with 20 or 40 mg. Characterisation of monocyte depletion in transgenic mice (CES1/Es1elo) suggested that colony stimulating factor 1 receptor loss on circulating cells contributed to ESM‐HDAC‐mediated depletion. Further mechanistic investigations using human monocytes in vitro demonstrated HDACi‐mediated change in myeloid fate through modulation of colony stimulating factor 1 receptor and downstream effects on cell differentiation.ConclusionThese findings demonstrate selective targeting of monocytes in humans using the ESM approach and identify monocytopaenia as a novel outcome of ESM‐HDACi treatment, with implications for potential benefit of these molecules in myeloid‐driven diseases.
T‐helper cell regulation of CD45 phosphatase activity by galectin‐1 and CD43 governs chronic lymphocytic leukaemia proliferation
Authors: Imbery John F. , Heinzelbecker Julia , Jebsen Jenny K. , McGowan Marc , Myklebust Camilla , Bottini Nunzio , Stanford Stephanie M. , Skånland Sigrid S. , Tveita Anders , Tjønnfjord Geir E. , Munthe Ludvig A. , Szodoray Peter , Nakken Britt 
Published: June 2022

SummaryChronic lymphocytic leukaemia (CLL) is characterised by malignant mature‐like B cells. Supportive to CLL cell survival is chronic B‐cell receptor (BCR) signalling; however, emerging evidence demonstrates CLL cells proliferate in response to T‐helper (Th) cells in a CD40L‐dependent manner. We showed provision of Th stimulation via CD40L upregulated CD45 phosphatase activity and BCR signalling in non‐malignant B cells. Consequently, we hypothesised Th cell upregulation of CLL cell CD45 activity may be an important regulator of CLL BCR signalling and proliferation. Using patient‐derived CLL cells in a culture system with activated autologous Th cells, results revealed increases in both Th and CLL cell CD45 activity, which correlated with enhanced downstream antigen receptor signalling and proliferation. Concomitantly increased was the surface expression of Galectin‐1, a CD45 ligand, and CD43, a CLL immunophenotypic marker. Galectin‐1/CD43 double expression defined a proliferative CLL cell population with enhanced CD45 activity. Targeting either Galectin‐1 or CD43 using silencing, pharmacology, or monoclonal antibody strategies dampened CD45 activity and CLL cell proliferation. These results highlight a mechanism where activated Th cells drive CLL cell BCR signalling and proliferation via Galectin‐1 and CD43‐mediated regulation of CD45 activity, identifying modulation of CD45 phosphatase activity as a potential therapeutic target in CLL.