bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID–19後に成人多系統炎症性症候群および特徴的な眼症状を呈した1例(A case of multisystem inflammatory syndrome in adults and characteristic ocular symptoms after COVID–19)
Authors: (Yusuke Shibata) 柴田 裕介 , (Takeru Maruyama) 丸山 尊 , (Momoko Iwamoto) 岩本 桃子 , (Hirotoshi Ide) 井出 博敏 , (Masashi Ooe) 大江 将史 , (Atsushi Shima) 島 惇 , (Takeshi Ueda) 上田 剛士 
Published: May 2022

要旨　成人多系統炎症性症候群（multisystem inflammatory syndrome in adult: MIS–A）は，COVID–19罹患後に発症する稀な症候群であるが，日本人のMIS–A症例はほとんど報告されていない。ここではCOVID–19から回復した3週間後に，多臓器不全（心血管や消化器）と顕著な炎症マーカーの上昇を呈した54歳日本人女性のMIS–A症例を報告する。経過中にぶどう膜炎を示唆する羞明，流涙を認めたことが特徴的であった。免疫グロブリン静注投与とステロイド投与により症状は改善した。入院19日目には退院し，その後再発はなかった。COVID–19罹患後の多臓器不全や眼症状を呈した患者を治療する際に，この症候群を認識することは重要である。
Quantitative assessment of viral load in the blood and urine of patients with congenital cytomegalovirus infection using droplet digital PCR
Authors: Yamaguchi Makoto , Kawada Jun‐ichi , Torii Yuka , Haruta Kazunori , Suzuki Takako , Horiba Kazuhiro , Takahashi Yoshiyuki , Ito Yoshinori 
Published: May 2022

AbstractCongenital cytomegalovirus infection (cCMV) is a common cause of congenital infections, leading to neurodevelopmental sequelae. Real‐time quantitative polymerase chain reaction (qPCR) has been widely used for the diagnosis and assessment of cCMV; however, the correlation between CMV DNA load and the severity of cCMV symptoms has been inconclusive. Droplet digital PCR (ddPCR) offers an improvement over the current qPCR methods through the absolute quantification of viral loads. We compared ddPCR and qPCR results for the quantification of CMV DNA in blood and urine specimens from 39 neonates with cCMV (21 symptomatic and 18 asymptomatic). There was no significant difference in blood CMV DNA loads measured by ddPCR and qPCR, with or without any clinical findings. However, developmental delays at 36 months were significantly more frequently observed in patients with high CMV DNA loads (≥2950 copies/ml), as measured by ddPCR at diagnosis, than in those with lower CMV DNA loads. The association of urine CMV DNA load with symptoms and developmental delay was not observed. CMV DNA loads in the blood might be used as a predictor of developmental outcomes in cCMV patients, and absolute quantitation of viral loads by ddPCR assay could contribute to the standardization of CMV load measurement.
Relationship between the subgingival microbiome and menopausal hormone therapy use: The Buffalo OsteoPerio study
Authors: Soliman Ahmed I. , LaMonte Michael J. , Hovey Kathleen M. , McSkimming Daniel I. , Andrews Chris A. , Diaz Patricia I. , Buck Michael J. , Sun Yijun , Millen Amy E. , Wactawski‐Wende Jean 
Published: May 2022

AbstractBackgroundThis study investigated the association between menopausal hormone therapy (HT) use and the subgingival microbiome, for which published information is limited.MethodsThis cross‐sectional study included 1270 postmenopausal women, aged 53–81 years, who completed clinical examinations. Detailed information on HT use (type, delivery mode, duration) was obtained from questionnaires. HT use was categorized into three groups (never, former, current). 16S rRNA sequencing was performed on subgingival plaque samples obtained during dental examinations. Operational taxonomic units were centered log2‐ratio (CLR) transformed to account for the compositional data structure. Analysis of variance was used to compare mean microbial relative abundances across HT categories with Benjamini‐Hochberg correction.ResultsSignificantly higher alpha diversity (Shannon Index) and beta diversity (Aitchison distance) was observed in never compared with current HT users (p < 0.05, each). Of the total 245 microbial taxa identified, 18 taxa differed significantly among the three HT groups, 11 of which were higher in current users and seven of which were lower in current users as compared with never users (p < 0.05, each). Differences in relative abundance between never and current HT users were materially unchanged after adjustment for age, body mass index, and oral hygiene.ConclusionsRelative abundance of several subgingival bacteria differed significantly between never and current HT users in a cohort of postmenopausal women. Additional studies are needed to determine the extent that these relationships might account for the previously reported inverse association between HT use and periodontal disease in older women.
Impact of COVID‐19 pandemic on pharmacist‐led allergy assessments and penicillin skin testing
Authors: Spivey Justin , Deri Connor R. , Wrenn Rebekah H. , Turner Nicholas A. 
Published: May 2022

AbstractAllergy assessments and penicillin skin testing are associated with reductions in high‐Clostridioides difficile infection (CDI)‐risk antibiotic use and lower hospital‐acquired CDI rates; however, these activities require substantial personnel and resource allocation. Recently, many antimicrobial stewardship programs’ (ASPs) focus shifted towards supporting the COVID‐19 pandemic response. We evaluated the impact of the COVID‐19 pandemic on a pharmacist‐led allergy assessment and penicillin skin testing program. Patients undergoing allergy assessment and/or penicillin skin testing (PST) from 1 January 2017 through 30 April 2021 were included for review. Monthly PST and allergy assessment rates were calculated and defined as the number of PSTs or allergy assessments per 1000 unique patient encounters for each month, respectively. The study used interrupted time series regression to assess potential level and slope changes in allergy assessments and PSTs during the pandemic. 200 058 total inpatient encounters by 188 867 unique patients occurred during the study period. ASP performed 918 allergy assessments and 204 PSTs. The local onset of the SARS‐CoV‐2 pandemic during March 2020 was associated with significant level reductions in allergy assessments and PSTs. Additional responsibilities added to the ASP team during the COVID‐19 pandemic limited the ability to perform core antimicrobial stewardship activities with proven patient care benefits.
Effects of high‐hydrostatic pressure and high‐pressure homogenization on the biological activity of cabbage dietary fiber
Authors: Chen Yu‐Rou , Wu Sz‐Jie 
Published: May 2022

AbstractBACKGROUNDCabbage is one of the most economical cooked vegetables in terms of its relatively low price and high nutritional value. It is rich in dietary fiber, multivitamins, and a variety of anti‐oxidants. In this study, we compared the effects of high‐hydrostatic pressure (HHP) and high‐pressure homogenization (HPH) treatments on changes in composition and physiological functions of cabbage dietary fiber.RESULTSThe total dietary fiber content (36.06 ± 1.65%) and nitrite ion adsorption capacity (2.37 ± 0.01 μmol·g−1) of HHP‐treated cabbage powder were higher than those of untreated cabbage powder. The soluble dietary fiber content (36.18 ± 0.89%) and the emulsifying activity (36.18 ± 0.89%) and emulsifying stability (47.88 ± 4.35%) of HPH‐treated cabbage powder were higher than those of untreated cabbage powders. The significant reduction in particle size induced by the high‐pressure treatments caused differences in the properties of the treated and untreated cabbage powder samples. Scanning electronic microscopy analysis revealed that the microstructure of the HPH‐treated cabbage powder changed from patches to fine granules with concave‐convex markings on the surface, and that the surface area was significantly higher than that of the untreated cabbage powder. The high‐pressure‐treated cabbage powder has good homogeneity sensory properties after rehydration. Moreover, the changes in the properties of cabbage powder induced by the high‐pressure treatments caused the cholesterol adsorption capacity and glucose dialysis retardation index of the treated cabbage powders to be higher than those of the untreated cabbage powder.CONCLUSIONIn summary, high‐pressure processing and micronization of cabbage can render it a multifunctional source of dietary fiber. We believe that this study provides a new method for processing and using leftover vegetables. © 2022 Society of Chemical Industry.
Construction of in vitro fermentation model using gut microbiota relating to glucose and lipid metabolism: a supplementary method for initial screening of polysaccharides with hypoglycemic potentials
Authors: Fan Jiaqi , Lin Lianzhu , Zhao Mouming 
Published: May 2022

AbstractBACKGROUNDBesides in vitro fecal fermentation model, a few supplementary methods have been constructed for high‐throughput screening of polysaccharides with hypoglycemic potentials. The purpose of this study was to establish a co‐culture fermentation model constructed by gut microbiota relating to glucose and lipid metabolism as a supplementary method for comparatively evaluating the proliferative effects and hypoglycemic potentials of typical plant polysaccharides, e.g. konjac glucomannan, Lycium barbarum L. polysaccharide, oat glucan and alga‐derived fucoidan.RESULTSThe results showed that the mixing culture medium of butyrate‐producing bacteria, Bacteroides, Bifidobacterium and Lactobacillus at a ratio of 50:40:9:1 was optimal. This testing model in line with quantitative polymerase chain reaction (qPCR) and metabolite analysis multi‐dimensionally differentiated four polysaccharides possessing different behaviors on proliferation of total bacteria and specific genus or strain and accumulation of short chain fatty acids.CONCLUSIONOur study provided crucial data for establishing an initial screening method for proliferative effect/specific structure‐oriented extraction of polysaccharide with hypoglycemic potential. © 2022 Society of Chemical Industry.
Personalization in personalized marketing: Trends and ways forward
Authors: Chandra Shobhana , Verma Sanjeev , Lim Weng Marc , Kumar Satish , Donthu Naveen 
Published: May 2022

AbstractIn marketing, personalization is the action of designing and producing in ways that resonate with customer preferences. Content and products that are personalized according to customer preferences can reduce customer fatigue and time in making choices, thereby decreasing their cognitive load. Despite its importance, the literature on personalized marketing remains fragmented due to the absence of a comprehensive review that consolidates the intellectual structure of the field. This study bridges this knowledge gap through a bibliometric review using performance analysis and science mapping. Through a comprehensive review of 383 publications, this study reveals the publication and citation trends, the most prolific authors, journals, and publications, and six major themes (i.e., personalized recommendation, personalized relationship, personalization–privacy paradox, personalized advertising, personalization concept and discourse in marketing, and customer insights in personalized marketing) that characterize the body of knowledge of personalized marketing. The study concludes with future research directions as ways forward for personalized marketing, wherein a focus on new‐age technologies involving artificial intelligence, big data, blockchain, internet of things, and wearables is encouraged to explore new ways to curate personalized experiences across online and offline channels.
Mass spectrometry in food authentication and origin traceability
Authors: Dou Xinjing , Zhang Liangxiao , Yang Ruinan , Wang Xiao , Yu Li , Yue Xiaofeng , Ma Fei , Mao Jin , Wang Xiupin , Zhang Wen , Li Peiwu 
Published: May 2022

AbstractFood authentication and origin traceability are popular research topics, especially as concerns about food quality continue to increase. Mass spectrometry (MS) plays an indispensable role in food authentication and origin traceability. In this review, the applications of MS in food authentication and origin traceability by analyzing the main components and chemical fingerprints or profiles are summarized. In addition, the characteristic markers for food authentication are also reviewed, and the advantages and disadvantages of MS‐based techniques for food authentication, as well as the current trends and challenges, are discussed. The fingerprinting and profiling methods, in combination with multivariate statistical analysis, are more suitable for the authentication of high‐value foods, while characteristic marker‐based methods are more suitable for adulteration detection. Several new techniques have been introduced to the field, such as proton transfer reaction mass spectrometry, ambient ionization mass spectrometry (AIMS), and ion mobility mass spectrometry, for the determination of food adulteration due to their fast and convenient analysis. As an important trend, the miniaturization of MS offers advantages, such as small and portable instrumentation and fast and nondestructive analysis. Moreover, many applications in food authentication are using AIMS, which can help food authentication in food inspection/field analysis. This review provides a reference and guide for food authentication and traceability based on MS.
Wide transmission band rasorber of center‐connected pattern with multi‐resonators
Authors: Lu Zeguo , Wei Jianfeng , Ye Hang , Zhang Hao , Dai Wentao , Bie Shaowei , Jiang Jianjun 
Published: May 2022

AbstractA wide‐transmission band rasorber is proposed in this letter. The structure consists of an lossy layer and a lossless layer. Since we find that the center‐connected pattern can achieve a wider bandwidth than the loop pattern, the lossy layer abandons the traditional loop pattern but uses a center‐connected pattern to cascade multiple resonators. In addition, we proposed a new co‐use resonator to further broaden the bandwidth. The simulated results show that the proposed rasorber has a transmission band (S21 〉 −1 dB) from 6.3 to 8.57 GHz, and the absorption band (S11 〈 −10 dB) is from 1.9 to 5 GHz. A prototype was fabricated and measured to validate our design. The simulated and measured results show good agreement, which prove the effectiveness of our design method. Compared with the previous FSRs, the proposed FSR yields a wider relative bandwidth with fewer resonators and can be fabricated more easily.
A review of planting principles to identify the right place for the right tree for ‘net zero plus’ woodlands: Applying a place‐based natural capital framework for sustainable, efficient and equitable (SEE) decisions
Authors: Bateman Ian J. , Anderson Karen , Argles Arthur , Belcher Claire , Betts Richard A. , Binner Amy , Brazier Richard E. , Cho Frankie H. T. , Collins Rebecca M. , Day Brett H. , Duran‐Rojas Carolina , Eisenbarth Sabrina , Gannon Kate , Gatis Naomi , Groom Ben , Hails Rosie , Harper Anna B. , Harwood Amii , Hastings Astley , Heard Matthew S. , Hill Timothy C. , Inman Alex , Lee Christopher F. , Luscombe David J. , MacKenzie Angus R. , Mancini Mattia C. , Morison James I. L. , Morris Aaron , Quine Chris P. , Snowdon Pat , Tyler Charles R. , Vanguelova Elena I. , Wilkinson Matthew , Williamson Daniel , Xenakis Georgios 
Published: May 2022

AbstractWe outline the principles of the natural capital approach to decision making and apply these to the contemporary challenge of very significantly expanding woodlands as contribution to attaining net zero emissions of greenhouse gases.Drawing on the case of the UK, we argue that a single focus upon carbon storage alone is likely to overlook the other ‘net zero plus’ benefits which woodlands can deliver.A review of the literature considers the wide variety of potential benefits which woodlands can provide, together with costs such as foregone alternative land uses.We argue that decision making must consider all of these potential benefits and costs for the right locations to be planted with the right trees.The paper closes by reviewing the decision support systems necessary to incorporate this information into policy and decision making.Read the freePlain Language Summaryfor this article on the Journal blog.
In situ photo‐crosslinked hydrogels prepared from acrylated 4‐arm‐poly(ethylene glycol)‐poly(ε‐caprolactone) block copolymers for local cancer therapy
Authors: Wang Yuandou , Wang Shuxin , Hu Wenju , Su Feng , Liu Fusheng , Li Suming 
Published: May 2022

AbstractAmphiphilic block copolymers were synthesized by ring‐opening polymerization of ε‐caprolactone (ε‐CL) using 4‐arm poly(ethylene glycol) (4aPEG) as macroinitiator. 4aPEG and 4aPEG‐PCL copolymers were end functionalized by introducing acrylic groups, and characterized using NMR, GPC, FT‐IR and DSC analyses. Photo‐crosslinked hydrogels were prepared by irradiation of acrylated polymer solutions under visible light (405 nm), using lithium phenyl‐2,4,6‐trimethylbenzoy‐lphosphinate (LAP) as a photoinitiator. In situ gelation was achieved by subcutaneous injection of LAP containing copolymer solution into the abdomen of mice, followed by exposure to visible light. The hydrogels exhibit highly porous structure, high swelling up to 3300%, and excellent biocompatibility. The swelling ratio decreases with increase of poly(ɛ‐caprolactone) (PCL) block length and polymer concentration of hydrogels. Doxorubicin hydrochloride (DOX·HCl) was loaded in hydrogels by soaking dried gel in a DOX solution. The drug loading efficiency is dependent on the swelling performance, reaching a maximum of 94.3%. In vitro drug release studies showed a burst release for the first 6 h, followed by a slower release up to 82% at 28 days. The release rate decreased with increase of hydrophobic block length or polymer concentration of hydrogels. Higher anti‐cancer activity on A549 lung cancer cells was obtained for hydrogels with higher drug concentration, and shorter PCL block length. Therefore, 4aPEG‐PCL hydrogels with outstanding biocompatibility, in situ gelation and prolonged drug release could be very promising for long‐term local cancer therapy.
Australian teacher stress, well‐being, self‐efficacy, and safety during the COVID‐19 pandemic
Authors: Billett Paulina , Turner Kristina , Li Xia 
Published: May 2022

AbstractThe 2020 COVID pandemic radically altered the way in which individuals live and work. For teachers, this entailed a shift in their teaching practice, with large numbers of schools around Australia and the world closing for prolonged periods of time and moving to an “online” format. This required teachers to quickly adapt their teaching practices adding further stress to an already stressful environment. In this article, we examine the relationships between teachers' stress, teachers' self‐efficacy, and teachers' well‐being during the COVID pandemic. The study presents the results from a quantitative survey undertaken in June and July 2020 with 534 teachers around Australia. While the study found that, overall, most teachers (77.29%) reported that they were not feeling anxious in their teaching role, teachers' responses indicated that they were experiencing high levels of stress and low levels of positive feelings such as joy, positivity, and contentment in their work during the COVID‐19 pandemic negatively impacting their well‐being and self‐efficacy.
Collaborative approaches to autism spectrum disorder assessment
Authors: Dale Brittany A. , Bray Melissa A. 
Published: May 2022

AbstractWith the rising prevalence rates of autism spectrum disorder (ASD), school and clinical psychologists must be abreast of the current research on assessment to determine diagnosis or educational eligibility. This is the first of a double special issue focusing on assessment of individuals with ASD. Within the school setting, collaboration is at the core of special education eligibility assessment. This introduction highlights the role of collaboration in the assessment process. Collaborative approaches help school psychologists determine the best assessment plan, understand the diversity, equity, and inclusive needs of children with ASD, and can assist in determining if alternative methods (i.e., telehealth) are appropriate.
Force sense deficits in chronic ankle instability: A systematic review and meta‐analysis
Authors: Xue Xiao'ao , Chen Ziyi , Xuan Wenkai , Tao Weichu , Jin Zhengbiao , Hua Yinghui 
Published: May 2022

AbstractObjectivePatients with chronic ankle instability (CAI) may experience ankle force sense deficits due to mechanoreceptor injury and proprioceptive deafferentation in the affected ankles. This study aimed to systematically review the literature and investigate (1) whether patients with CAI have impaired force sense when compared with uninjured contralateral sides or healthy controls, and (2) which characteristics of CAI (e.g., any measurement of CAI symptoms, clinical questionnaires, or functional tests on the injured ankles) are correlated with force sense deficits.TypeSystematic review and meta‐analysis.Literature SurveyPubMed, Embase, Web of Science, Cochrane Library, Scopus, CINAHL, and SPORTDiscus were searched for ankle‐related, injury‐related, and force sense‐related terms from inception to February 2, 2022.MethodologyThe following information was extracted from included articles: demographic data, sample size, selection criteria, methodology, force reproduction test outcomes, and correlations between force sense and other characteristics of CAI. Meta‐analyses were conducted for the force sense outcomes, and a narrative review was undertaken for the correlation between force sense deficits and other characteristics of CAI.SynthesisEight studies were included. The meta‐analyses revealed eversion force sense deficits of the injured ankles in absolute error (magnitude of force reproduction error) at 20% maximal voluntary isometric contractions (MVIC) (standardized mean difference [SMD] = 0.67, 95% confidence interval [CI] 0.23–1.11) and variable error (consistency of force reproduction) at 30% MVIC (SMD = 0.46, 95% CI 0.07–0.85), as compared with healthy controls. None of the included studies reported a significant correlation between these two deficits and other characteristics of CAI.ConclusionsPatients with CAI have eversion force sense deficits in the magnitude of force reproduction error at 20% MVIC and the consistency of force reproduction at 30% MVIC.
A Review of the Synthesis, Properties, and Applications of 2D Materials
Authors: Shanmugam Vigneshwaran , Mensah Rhoda Afriyie , Babu Karthik , Gawusu Sidique , Chanda Avishek , Tu Yongming , Neisiany Rasoul Esmaeely , Försth Michael , Sas Gabriel , Das Oisik 
Published: May 2022

AbstractIn the modern age of nanotechnology, the discovery of graphene has opened up the way to study and develop of several novel 2D materials. The unique physical and chemical properties of 2D materials have enhanced their research, making them superior to the commercial bulk materials used in various applications. Efforts have been made in the current study to present an overview of the intrinsic properties of these materials. Furthermore, synthesis and applications are also reviewed and discussed. Finally, the future outlook of 2D materials is discussed to enhance the research and performance of these materials, which can result in broader applications benefitting the electrical and electronics industries and society. Intensive research into 2D materials is expected to lead to the discovery of new materials with enhanced properties that will benefit the industry and society at large.
Protein folding and unfolding: proline cis‐trans isomerization at the c subunits of F1FO‐ATPase might open a high conductance ion channel
Authors: Nesci Salvatore 
Published: May 2022

AbstractThe c subunits, which constitute the c‐ring apparatus of the F1FO‐ATPase, could be the main components of the mitochondrial permeability transition pore (mPTP). The well‐known modulator of the mPTP formation and opening is the cyclophilin D (CyPD), a peptidyl‐prolyl cis‐trans isomerase. On the loop, which connects the two hairpin α‐helix of c subunit, is present the unique proline residue (Pro40) that could be a biological target of CyPD. Indeed, the proline cis‐trans isomerization might provide the switch that interconverts the open/closed states of the pore by pulling out the c‐ring lipid plug.