bluuebunny/crossref_metadata_2025_split huggingface dataset:
The management of tubo-ovarian abscess - A retrospective analysis of a centre offering outpatient intravenous antibiotic therapy
Authors: Teh Jhia Jiat , Wali Sarah , Mollier Josephine , Gilchrist Mark , Miskry Tariq 
Published: April 2022

Background Tubo-ovarian abscess (TOA) carries long-term sequale in women of reproductive age. Consensus of the optimal treatment of tubo-ovarian abscess remains lacking. The aims of this study are to identify risk factors predicting the need for early drainage and compare clinical outcomes of current management practices of TOA. Methods From 2015 to 2019, a retrospective cohort study of 92 women admitted to a tertiary centre for gynaecological surgery was performed. Patients with diagnosed TOA were classified into two groups: treatment with antibiotics only, and those receiving additional drainage. Primary outcomes included length of hospital stay (LoS), length of antibiotic treatment (LoA) and need for re-intervention. Results In this study, 52 women (56.5%) were successfully treated with first line intravenous antibiotics; 40 (43.5%) received surgical drainage. Significant predictors for successful medical treatment only include age < 35 (OR: 0.89, 95% CI: 0.82-0.97) and abscess size < 6cm (OR: 0.17, 95% CI: 0.04-0.64), using multivariate analysis. Pyrexia ≥ 38°C predicted a need for drainage (OR: 3.82, 95% CI: 1.01-8.12). Patients who received additional drainage had significantly longer LoA, LoS and higher rates of re-intervention. Within this group, drainage within 72 hours of admission resulted in a trend towards shorter LoA and LoS than drainage after 72 hours, albeit not statistically significant. Conclusions Parameters include age > 35 years, pyrexia ≥ 38°C and a TOA size > 6cm may independently predict the need for drainage of TOA. Early identification of these patients is imperative for timely surgical intervention to avoid prolonged hospitalisation, antibiotic usage, and patient morbidity. More work is required to identify whether early drainage may reduce length of hospital stay and antibiotic treatment, including identifying certain patient groups who most likely to benefit from outpatient antibiotic intravenous therapy.
An evaluation of the psychometric properties of the Fear of COVID-19 Scale in a sample of help-seeking men
Authors: Rice Simon , Trail Katherine , Walton Courtney , Kealy David , Seidler Zac , Wilson Michael , Oliffe John , Ogrodniczuk John 
Published: April 2022

Aim of the studyThe Fear of COVID-19 Scale is a widely used measurement tool for related anxieties, however previous studies validating the scale report varying fit indices, often below accepted cut-off points. This suggests re-specification of the scale may be required. The present study aimed to examine the psychometric properties of the English-version of the Fear of COVID-19 Scale in a population of help-seeking males using exploratory (EFA) and confirmatory factor analysis (CFA).Subject or material and methodsData from 621 males aged 18-80 years (mean=38.23, SD=13.59) was collected via a cross-sectional open online survey. Along with the 7-item Fear of COVID-19 Scale, the PHQ-4 and PROMIS Anger Short Form were used to measure probable anxiety, depression and anger. Data were randomly partitioned into two subsamples and separate factor analyses were conducted with robust CFA corrections applied for non-normality.ResultsA 4-item single-factor version of the scale was identified reporting excellent model fit (R-RMSEA=.033, R-CFI=.998, R-TFI=.997, SRMR=.012) and good internal consistency (α=.86). Age and probable anxiety effects were observed.DiscussionRelative to existing validation studies of the Fear of COVID-19 Scale, the present study provides improved psychometrics of the 4-item version of the scale, while scale means observed were comparable to other studies.ConclusionsThis study validates a 4-item version of the Fear of COVID-19 Scale to assess related anxieties in a help seeking male population. Future research should seek to validate the 4-item version in other subpopulations.
The preliminary efficacy and clinical applicability of Brainspotting among Filipino women with severe posttraumatic stress disorder
Authors: PALSIMON JR. TEOFILO 
Published: April 2022

Aim of the studyThis paper aims to examine the efficacy of Brainspotting in ameliorating PTSD symptoms among female residential patients across three-time points.Subject or material and methodsThis study employed a one-group pretest-posttest with delayed posttest quasi-experimental design to establish and determine causal change among different conditions. Different versions of gold-standard measures were administered to individuals with trauma exposure; the Clinician-Administered PTSD Scale 5 (CAPS-5) and the Posttraumatic Stress Disorder Checklist 5 (PCL-5). The sample comprised 13 participants at the Marillac Hills Alabang who incurred severe interpersonal trauma and suffered markedly elevated PTSD symptoms for at least two years. They received three sessions of BSP guided by a therapist's manual and were assessed at three-time points – pretreatment, posttreatment, and two weeks after the treatment completion. Primary data include self-report posttraumatic stress symptoms, which were analyzed using repeated-measures ANOVA with a Greenhouse-Geisser correction and post-hoc test with a Bonferroni correction.ResultsResults showed significant improvements in both measures with large effect sizes from 0.859 to 0.979.DiscussionSome of the few rigorous studies that have been conducted also demonstrated similar findings indicating discharge of trauma sequelae manifested by amelioration of intrusion, low level of subjective units of distress, and regulated sensorimotor reactionsConclusionsAt α0.01 (99%) confidence interval, the results suggest that BSP has significant efficacy in decreasing posttraumatic stress symptoms. After the three BSP sessions, all participants were assessed with absent to mild PTSD symptoms. The effects of the program persisted during the short-term follow-up evaluation.
A bank’s intellectual capital and its importance in building competitiveness on the example of Polish listed banks
Authors: Anielak-Sobczak Karolina 
Published: April 2022

Motivation: Contemporary banks operating in the knowledge-based economy are constantly looking for sources of improving their competitiveness and attractiveness compared to the banking sector. Therefore, the ability to flexibly respond to changes taking place in the market environment and use the resources and experience in a creative way becomes essential. Intellectual capital is a source of the bank’s intangible resources, such as knowledge, employee skills, service quality, social relations and image, and innovations. The present study focuses on the structure of intellectual capital, which has been long discussed for a long time and became a subject of numerous studies. The concept of division of the bank’s intellectual capital into three subsystems was herein presented: organizational capital (KORG), innovative capital (KINN) and institutional capital (KINS). These subsystems will be included in the creation of a synthetic measure defining the bank’s competitiveness.
Aim: The objective of this study is to present a method enabling the assessment of the competitiveness of listed banks in Poland with the use of multidimensional statistical methods, taking into account diagnostic variables that determine the economic and intellectual capital of banks, including its subsystems.
Results: The article systematizes the concept of the division of intellectual capital. Thanks to the aggregate measure of the bank’s competitiveness, the author presented a ranking of banks, indicating the leader among the 11 banks listed on the stock exchange in Poland in 2009–2019. The proposed multidimensional analysis of the bank considers its financial and intellectual resources, which means that stakeholders can evaluate the bank’s data and its long-term development strategies. The long-term leadership position may indicate the bank’s condition and its intensified activities in intellectual capital development, which may be important information for stakeholders.
The analysis of human capital in the context of local economic development
Authors: Knapińska Magdalena , Siński Wojciech 
Published: April 2022

Motivation: The study of local economies has become a significant part of the theoretical and practical approach to economic research. It is important to define variables used for modeling, so the aim of this paper is to identify human capital as the determinant of local economic development. While studies are often conducted on the basis of research material describing a given unit of territorial self-government, the methodology can be applied more broadly.
Aim: The aim of the paper is to define the key elements of human capital, which can be used for modeling economic development in the local context. Local development is influenced by a number of factors, such as physical capital, human capital and natural resources, but in this paper we focus both on the analysis of the variables describing human capital both at the moment of examination and of those which will affect its quality in the future.
Results: The research findings reveal that human capital in Ustka was subject to significant changes in the period under study and its quality is determined by the economic development of this commune. What is also important is the fact that the variables describing human capital indicate the improvement in the quality of this capital in this territorial unit. Further research into local development should thus take into consideration this significant aspect of economy.
The role of intangible resources in shaping the financial potential of high technology enterprises on the example of CD Projekt SA
Authors: Perło Dorota , Arszułowicz Norbert 
Published: April 2022

Motivation: As a result of economic changes over the last few decades, the structure of enterprise resources has changed significantly. Therefore, their development potential is concentrated on intangible resources. A reflection of these changes is the emergence of the Resource-Based View of the Firm (RBV) which has its roots in the works of scientists such as: J.A. Schumpeter, A. Marshall, or E.H. Chamberlin. The importance of the resource theory is mainly based on the technological potential, people’s knowledge or the improvement of management techniques.
Aim: The aim of the article is to propose a method for assessing the strength and direction of the impact of intangible resources on the financial potential of high-tech enterprises. In the article, as a case study, the impact of intangible resources on the financial potential of CD Projekt SA was presented. from the high-technology industry (Section C, subclass 26.20.) in 2011–2019. The choice of the company as the research object was primarily determined by the type of business activity, the high position of the enterprise among the fastest growing companies and a significant share of intangible resources.
Results: To achieve the aim of the article, the soft modeling method was used which allows to study the relationship between directly unobservable variables. In the constructed soft model, two unobservable (hidden) variables constituting the internal model were adopted: intangible resources (IR) and financial potential (FP). Hidden variables were defined based on the potential set of indicators (observable variables). Specification of the model of the soft impact of intangible resources on the financial result of high-tech enterprises based on the concept of the resource theory. Identification of the most important variables shaping the intangible resources of high technology enterprises, their impact on the financial potential of enterprises, together with the analysis of the dynamics of changes. Defining proposals for recommendations for high-tech companies based on the results of empirical research.
Acute lymphoblastic leukemia (ALL) with KMT2A gene rearrangement in infants - characteristic clinical picture based on a case report
Authors: Kowalczuk Maria , Lipińska Justyna , Lipiński Łukasz , Lejman Monika , Zawitkowska Joanna 
Published: April 2022

The most common malignancy affecting children is leukemia, which in infants refers to be diagnosed before 1 year of age and is relatively rare, but remains a problem for clinicians due to its aggressive clinical presentation, poor response to current treatments, and molecular biology. Infants with acute leukemia tend to present with aggressive features, including hyperleukocytosis, hepatosplenomegaly, central nervous system (CNS) involvement, and cutaneous infiltration. In infant leukemia, the KMT2A gene rearrangement at chromosome 11q23 is quite common. Infants diagnosed with acute leukemia harboring a 11q23 rearrangement have a particularly poor prognosis when compared to other children with acute leukemia.
A 10-month-old girl was admitted in December 2017 to the Department of Pediatric Hematology, Oncology and Transplantology in Lublin with the suspicion of leukemia. One week before hospitalization minor bruises began to appear on the skin, unrelated to an injury. The child was admitted to the hospital, and there a complete blood count showed anemia, hiperleukocytosis and thorombocytopenia. On the admission to the Clinic: the severe general condition of the patient, with features of cardiopulmonary insufficiency were confirmed. Due to the patient's age and the presence of the KMT2A/MLLT3-t(9;11) (p22;q23) gene rearrangement, the infant was stratified as a high-risk group (HRG) and chemotherapy was started in accordance with the therapeutic program.
Infant leukemia is one of the most difficult clinical situations encountered in pediatric oncology. Given the infant’s vulnerability and unique genetic rearrangements, there is a need to develop new protocols and therapies for infants.
Neuro-endocrine mechanism of specific balneoeffects of sulfate-chloride sodium-magnesium mineral waters
Authors: Hrytsak Myroslava , Popovych Dariya , Ruzhylo Sofiya , Zakalyak Nataliya , Zukow Walery 
Published: April 2022

Background. Earlier we showed that the newly created sulfate-chloride sodium-magnesium drinking mineral waters “Myroslava” (5 g/L) and “Khrystyna” (10 g/L) have favorable effects on neuroendocrine-immune complex and metabolism of patients with their violations. At the same time, the influence of both waters on one constellation of parameters is similar, despite the twofold difference in mineralization, while on the other constellation it is different. The aim of this study was to elucidate the neuroendocrine mechanism of specific effects. Materials and Methods. The object of clinical-physiological observation were 22 men aged 23-70 years, who underwent rehabilitation treatment of chronic pyelonephritis and cholecystitis in remission in the Truskavets’ spa. The examination was performed twice, before and after a 7-10-day course of balneotherapy. All patients received bioactive water Naftussya, however, 11 men additionally drank water "Khrystyna", and the other 11 men - water "Myroslava". The subject of the study were the parameters of the neuroendocrine-immune complex and metabolism. Results. The method of canonical analysis shows that the changes in neuroendocrine factors (LF and VLF bands HRV; beta- and delta-rhythm-generating nerve structures, cortisol and aldosterone determine changes in the parameters of immunity, microbiota, metabolism and cholekinetics by 99,5-98,6%. Conclusion. The primary effects of mineral waters are the modulation of the activity of the structures of the central and autonomic nervous and endocrine systems, which, in turn, have a regulatory modulating effect on the immune system, microbiota, metabolism, cholekinetics and blood pressure.
The associations of implant and patient factors with migration of the tibial component differ by sex
Authors: Laende Elise K. , Mills Flemming Joanna , Astephen Wilson Janie L. , Cantoni Eva , Dunbar Michael J. 
Published: April 2022

Aims Thresholds of acceptable early migration of the components in total knee arthroplasty (TKA) have traditionally ignored the effects of patient and implant factors that may influence migration. The aim of this study was to determine which of these factors are associated with overall longitudinal migration of well-fixed tibial components following TKA. Methods Radiostereometric analysis (RSA) data over a two-year period were available for 419 successful primary TKAs (267 cemented and 152 uncemented in 257 female and 162 male patients). Longitudinal analysis of data using marginal models was performed to examine the associations of patient factors (age, sex, BMI, smoking status) and implant factors (cemented or uncemented, the size of the implant) with maximum total point motion (MTPM) migration. Analyses were also performed on subgroups based on sex and fixation. Results In the overall group, only fixation was significantly associated with migration (p < 0.001). For uncemented tibial components in males, smoking was significantly associated with lower migration (p = 0.030) and BMI approached significance (p = 0.061). For females with uncemented components, smoking (p = 0.081) and age (p = 0.063) approached significance and were both associated with increased migration. The small number of self-reported smokers in this study warrants cautious interpretation and further investigation. For cemented components in females, larger sizes of tibial component were significantly associated with increased migration (p = 0.004). No factors were significant for cemented components in males. Conclusion The migration of uncemented tibial components was more sensitive to patient factors than cemented implants. These differences were not consistent by sex, suggesting that it may be of value to evaluate female and male patients separately following TKA. Cite this article: Bone Joint J 2022;104-B(4):444–451.
Non-invasive prenatal paternity testing by analysis of Y-chromosome mini-STR haplotype using next-generation sequencing
Authors: Song Wenqian , Xiao Nan , Zhou Shihang , Yu Weijian , Wang Ni , Shao Linnan , Duan Ying , Chen Mei , Pan Lingzi , Xia Yuexin , Zhang Li , Liu Ming 
Published: April 2022

Objectives
To assess the efficacy of Y-chromosome mini-STR-based next-generation sequencing (NGS) for non-invasive prenatal paternity testing (NIPPT).

Methods
DNA was extracted from the plasma of 24 pregnant women, and cell-free fetal DNA (cffDNA) haplotyping was performed at 12 Y-chromosome mini-STR loci using the Illumina NextSeq 500 system. The cffDNA haplotype was validated by the paternal haplotype. Subsequentlly, the paternity testing parameters were attributed to each case quantitatively.

Results
The biological relationship between the alleged fathers and infants in all 24 family cases were confirmed by capillary electrophoresis (CE). The Y-chromosome mini-STR haplotypes of all 14 male cffDNA were obtained by NGS without any missing loci. The alleles of cffDNA and paternal genomic DNA were matched in 13 cases, and a mismatched allele was detected at the DYS393 locus in one case and considered as mutation. No allele was detected in the 10 female cffDNA. The combined paternity index (CPI) and probability of paternity calculation was based on 6 loci Y-haplotype distributions of a local population. The probability of paternity was 98.2699–99.8828% for the cases without mutation, and 14.8719% for the case harboring mutation.

Conclusions
Our proof-of-concept study demonstrated that Y-chromosome mini-STR can be used for NGS-based NIPPT with high accuracy in real cases, and is a promising tool for familial searching, paternity exclusion and sex selection in forensic and medical applications.
“It’s hard to keep a distance when you’re with someone you really care about”—A qualitative study of adolescents’ pandemic-related health literacy and how Covid-19 affects their lives
Authors: Riiser Kirsti , Richardsen Kåre Rønn , Haraldstad Kristin , Helseth Sølvi , Torbjørnsen Astrid 
Published: April 2022

Purpose
The aim of this study was to explore how adolescents accessed, understood, appraised, and applied information on pandemic preventive measures, how their lives were impacted by long-lasting regulations and how they described their quality of life.

Methods
A qualitative design with focus group interviews was used to elaborate on the quantitative survey results obtained and analyzed in a previous survey study from the first phase of the Covid-19 pandemic. Five focus groups with seventeen adolescents were conducted digitally during the second pandemic phase in November and December 2020. The interview data were analyzed with directed content analysis.

Results
The adolescents reported using traditional media and official websites as sources for Covid-19 information. They engaged in preventive behavior, and washing hands and keeping a distance from strangers had become a habit. However, not being physically close to friends felt strange and unpleasant. The measure most frequently discussed was limiting social contact, which was a constant struggle. No one disputed the authorities’ guidelines and rules, but the social restrictions caused boredom and despair, particularly due to interrupted schooling and missed opportunities to engage in life events, and freely socialize with friends.

Conclusion
The adolescents gave an overall impression of being health literate, which corresponds well with the results from our previous survey study. Their descriptions of how they translated protective measures into their everyday lives demonstrate that they took responsibility and accepted personal costs for the collective good. However, life with social restrictions decreased their quality of life.
The association between provider characteristics and post-catheterization interventions
Authors: Powell Adam C. , Goldstein Jason P. , Long James W. , Simmons Jeffrey D. , DeFrance Anthony 
Published: April 2022

Objectives
To examine whether the demographics of providers’ prior year patient cohorts, providers’ historic degree of catheter-based fractional flow reserve (FFR) utilization, and other provider characteristics were associated with post-catheterization performance of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG).

Study design
A retrospective, observational analysis of outpatient claims data was performed.

Methods
All 2018 outpatient catheterization claims from a national organization offering commercial and Medicare Advantage health plans were examined. Claims were excluded if the patient had a prior catheterization in 2018, had any indications of CABG or valvular heart disease in the prior year of claims, or if the provider had ≤10 catheterization claims in 2017. Downstream PCI and CABG were determined by examining claims 0–30 days post-catheterization. Using multivariate mixed effects logistic regression with provider identity random effects, the association between post-catheterization procedures and provider characteristics was assessed, controlling for patient characteristics.

Results
The sample consisted of 31,920 catheterization claims pertaining to procedures performed by 964 providers. Among the catheterization claims, 8,554 (26.8%) were followed by PCI and 1,779 (5.6%) were followed by CABG. Catheterizations performed by providers with older prior year patient cohorts were associated with higher adjusted odds of PCI (1.78; CI: 1.26–2.53), even after controlling for patient age. Catheterizations performed by providers with greater historic use of FFR had significantly higher adjusted odds of being followed by PCI (1.73; CI: 1.26–2.37).

Conclusion
Provider characteristics may impact whether patients receive a procedure post-catheterization. Further research is needed to characterize this relationship.