bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distant Ocular Manifestations after New Coronavirus Infection
Authors: Plyaskina U. S. , Frolov M. A. , Frolov A. M. 
Published: April 2022

Purpose. Theoretically substantiate and practically identify ocular manifestations after the transferred SARS-CoV-2 virus.Patients and methods. For the study we were invited patients who had recovered from SARS-CoV-2 at the hospital of V.M. Buyanova, the age from 20 to 65 years old in period from 2020 to 2021. The total number of patients was 68 people. The patients had with them the results of PCR tests or ELISA tests, or an extract from the hospital confirmed COVID-19 case and also a clinical blood test and CT scan of the chest organs for the period of illness. Before the start of the study, the patients were asked to fill out a questionnaire “Questionnaire for patients who have had a new coronavirus infection” (Appendix 1). For a detailed study of this group of people, each underwent visometry, pneumotonometry, B-scan, a slit lamp study and also a slit lamp study with a 60D lens using 0.5 % Mydriacyl eye drops in the absence of contraindications and pupillography.Results. As a result of the work carried out, we concluded that the virus is capable of causing inflammation of the choroid of the eyeball, uveitis. Moreover, in our study, we identified patients with acquired intermittent divergent strabismus, anisocoria, ptosis, and accommodation disorder. And, in this regard, we came to the conclusion that the coronavirus belongs to the group of neurotropic, as it is able to affect the nervous tissue and cause the above clinical picture. In other words, the virus negatively affects the somatic and autonomic innervation of the oculomotor nerve. As a result of these lesions, we get the corresponding tetrad of symptoms: heterotropy, mydriasis, ptosis, accommodation paralysis.Conclusions. One of the extraordinary complications of coronavirus infection is damage effect to the fibers of the oculomotor nerve, the signs include: strabismus, mydriasis, ptosis and accommodation paralysis. Thus, this clinical picture is associated with the affinity of the virus to the nervous tissue. And as a result, this ability of the virus can probably infect various areas of the brain, which will lead to corresponding complications, not only from the oculomotor nerve, but also from other cranial nerves with the manifestation of the corresponding symptoms, which in theory can aggravate the patient’s condition , causing deep disturbances of motor and sensory innervation.
AMMI Analysis of Yield Performance in Foxtail Millet [Setaria italica (L.) P. Beauv.] Genotypes for Adaptation to Rainfed Conditions in Andhra Pradesh
Authors: Madhavilatha L. , Reddy C.V. Chandra Mohan , Priya M. Shanthi , Anuradha N. , Narasimhulu R. , Reni Y. Pushpa , Reddy C. Kiran Kumar , Kumar M. Hemanth 
Published: April 2022

Background: Foxtail millet is a short duration crop which is suitable for different cropping systems in rainfed farming. Improvement of yields is necessary to achieve profits in rainfed situation which is highly influenced by the high yielding varieties. Genotype by environment interaction (G×E) causes genotypes failure to keep high performance in all environments. Location specific climatic conditions also influence significantly genotype × environment (G×E) interaction, so with the result that identifying stable genotypes for rainfed situations is difficult. The study was conducted with a prime objective to identify stable high yielding foxtail millet genotypes for rainfed cultivation and to identify ideal mega-environments using additive main effects and multiplicative interaction stability model analysis. Methods: Four prerelease promising foxtail millet genotypes including three released popular check varieties were evaluated across six locations in Andhra Pradesh during Kharif, 2018 under rainfed situation. Result: The culture, SiA 3159 was found to be stable performer across the locations indicating that it is suitable for wide range of environments. In contrast the genotypes SiA 3085 and SiA 3156 showed narrow adaptation, specifically adapted to Anantapur (rainfed situation having scarce rainfall) and Vizianagaram (favorable environments with assured rainfall areas) respectively.
RESPECTFUL-BASED ASSESSMENT: SEBUAH MODEL ASESMEN BIMBINGAN DAN KONSELING BAGI KLIEN DALAM LINGKUP KOMUNITAS
Authors: Haryadi Rudi , Handayani Eka Sri , Ridhani Akhmad Rizkhi 
Published: April 2022

Penelitian ini bertujuan untuk mengembangkan model baru asesmen non-tes bimbingan dan konseling yang relevan dengan asumsi multikultural dan beorientasi keadilan sosial yang termanifestasi dalam kerangka RESPECTFUL bagi klien dalam lingkup komunitas (luar sekolah). Desain penelitian yang digunakan adalah model PPE Richey & Klein level 1. Model asesmen dirancang oleh peneliti berdasarkan hasil studi literatur. Kuesioner delphi kemudian dibagikan kepada 3 orang ahli dan 4 orang praktisi komunitas untuk menguji konten asesmen yang dikembangkan. Hasil validasi konten menunjukkan bahwa model yang dikembangkan sudah termasuk dalam kategori sangat baik dan dapat digunakan di lapangan dengan beberapa modifikasi, seperti perlu adanya: (1) spesifikasi komunitas target; (2) perbaikan redaksi kalimat; (3) perubahan nama; dan (4) penjelasan syarat-syarat responden. Walau demikian keefektifan penggunaannya di lapangan perlu dipastikan lebih lanjut melalui uji coba lapangan. Direkomendasikan kepada peneliti selanjutnya untuk melakukan uji lapangan model asesmen ini dengan target komunitas yang spesifik dan mengembangkan asesmen lebih luas agar dapat menjangkau komunitas klien yang khusus seperti difabel, anak-anak, dan orang tua.
KATA KUNCI: RESPECTFUL, Asesmen Non-Tes, Konseling Komunitas, Konseling di Luar Sekolah
A Pore-Geometry-Based Thermodynamic Model for the Nanoconfined Phase Behavior in Shale Condensate Reservoirs
Authors: Zhang Min , Liu Renjing , Hu Jinghong , Zhang Yuan 
Published: April 2022

Abstract
Shale condensate reservoirs, as one of the most important unconventional resources, have been attracting more and more attention recently. Researchers have developed several models for analyzing the phase behavior in nanopores. However, investigation of pore-geometry-based nanopore confinement is still lacking in the oil industry. Therefore, we develop a comprehensive thermodynamic model to satisfy this gas and simulate to the Eagle Ford shale condensate reservoirs. The model is first built with modification of the PR-EOS coupling the pore-geometry-based capillarity and adsorption. The Multicomponent Langmuir (ML) adsorption model is utilized. A good agreement is shown between this proposed model and the experimental data, which is associated with bulk fluid and confined fluid. After that, phase behavior of C1-C10 and C1-C4 mixtures is analyzed. Results indicate that capillarity and adsorption can result in noticeable deviation in the phase envelope. Additionally, pores with square and triangular cross-sections are analyzed, illustrating that pore geometries also have a significant influence on the phase behavior. Finally, a case study of the Eagle Ford shale condensate reservoir is performed. Phase behaviors in different pore geometries are analyzed by the ML adsorption model in detail, which will be more realistic than only circle pores. Moreover, we examine the physical properties of fluid in the Eagle Ford shale condensate reservoir. This work provides useful insights into the phase behavior of nanopores in shale formation, especially in the case of CO2-EOR in the shale condensate reservoirs.
Recurrence and Clustering of Large Earthquakes along the Northern Boundary of Ordos Block: Constraining Paleoearthquakes by an Improved Multiple Trench Constraining Method
Authors: Peng Hui , Zhang Dongli , Zheng Wenjun , Zhang Zhuqi , Bi Haiyun , Liang Shumin , Yang Jingjun 
Published: April 2022

AbstractTectonic belts along active tectonic block boundaries comprise one or more active faults; along which, large earthquakes recur. Therefore, it is important to establish the recurrence behavior of large earthquakes along such boundary zones for studying their characteristics and developments. Many paleoearthquake studies make it possible to investigate the recurrence behavior of large earthquakes along the northern boundary of the Ordos block (NBOB). Based on the previous studies, data from 52 trenches were collected to reconstruct prehistoric earthquakes using an improved multiple trench constraining method. This method is based on paleoearthquake indicators and trench location distribution to constrain the rupture time and length, thereby reducing the selection bias of fixed rupture length to construct additional rupture scenarios. The results suggest that the NBOB comprises four normal faults (from west to east): the Langshan Piedmont Fault (LPF), Sertengshan Piedmont Fault (SPF), Wulashan Piedmont Fault (WPF), and Daqingshan Piedmont Fault (DPF); along which, six, seven, eight, and six paleoearthquakes have occurred within approximately 15,000 yr, respectively. In addition, recurrence behaviors of the individual faults exhibit remarkable periodicity. The regional fault network along the NBOB reveals clustered characteristics with six clusters propagating either westward or eastward and a recurrence time of approximately 1,300 yr. Large earthquake events have occurred along the LPF, WPF, and DPF according to the most recent cluster; however, earthquakes were absent along the SPF, and no evidence of large earthquakes was observed along the NBOB after the 849 CE earthquake. Thus, we discuss the possibility of occurrence of large earthquakes along the SPF after the 849 CE earthquake based on earthquake recurrence and cluster migration behavior. Additional research is required to assess the potential risk of the occurrence of a large earthquake along the SPF in the future.
A Semianalytical Formulation for Estimating Induced Surface Subsidence of a Poroelastic Reservoir
Authors: Wang Shihao , Zhang Yanbin , Liu Zhe , Wen Xian-huan 
Published: April 2022

Summary
Monitoring and controlling surface subsidence are important to the safety of production operations as well as to the compliance of environmental regulations. Quantitively predicting surface subsidence caused by subsurface pressure change due to well production or injection would be very useful for operators. However, running a 3D geomechanics simulation for such a purpose is technically demanding and computationally expensive. Currently, a quick and easy alternative to get accurate results to fulfill such a task is lacking. In this work, we propose a semianalytical formulation to efficiently calculate the surface subsidence of a reservoir during the primary and enhanced recovery processes. Our method is based on the Green’s function solution of the Navier-Beltrami-Michell equation of poroelastic rocks. It takes the pressure field from a reservoir simulator or an analytical solution as the input and calculates the surface displacement along the vertical direction. We benchmarked the proposed formulation with numerical methods on a refined grid as well as with a semianalytical solution to ensure its accuracy. We applied the developed formulation to optimize the injection well position and vertical injection zone for pressure management. Compared to the previous analytical formulations that are based on the average pressure decline of the reservoir, our method explicitly considers the spatial distribution of the pressure field and is therefore more accurate. Compared with numerical methods, our method avoids the discretization of the caprock region and is thus faster by several orders of magnitude.
Wrist-ankle acupuncture for the treatment of acute orthopedic pain after surgery: a meta-analysis
Authors: Chen Mengli , Xu Yiyin , Fu Xiuzhen , Xie Jiewei , Cao Xuewei , Xu Yisheng 
Published: April 2022

Abstract
Background：Wrist-ankle acupuncture (WAA) have been reported in treatment of acute pain in orthopedic surgery, however, the effects of WAA on acute pain were controversial in the current studies. Therefore, the purpose of this meta-analysis was to critically evaluate the effect of WAA on acute pain in orthopedic surgery.Methods: Several digital databases were searched from the inception of databases to July 2021, including CNKI, VIP, Wanfang, CBM, Pubmed, Cochrane Central Register of Controlled Trials, Embase, Medline and Web of Science Core Collection. The risk of bias was evaluated using the cocharne collaboration criteria. The primary outcome indicators included pain score, the dosage of pain killer, analgesia satisfaction, and adverse reaction incidence. All analyses were performed with Review Manager 5.4.1.Result: A total 10 studies with 725 patients with orthopedic surgery (intervention group: 361, control group: 364) were included in this meta-analysis. The results demonstrated that the pain score of intervention group were lower than the control group, and the difference was statistically significant [MD= -0.29，95%CI(-0.37,-0.21),P<0.0001]. Compared with the control group, the patient in intervention group used smaller amounts of pain killer [MD= -0.16，95%CI(-0.30,-0.02),P=0.02]. the satisfaction of patients on pain relief was also higher in intervention group, and the difference was statistically [OR= 0.25，95%CI(0.15,0.41) , P<0.0001].Results: WAA has a certain effect on acute pain in orthopedic surgery, and the effect of WAA combined with other therapies is better than that not using WAA therapy.
Smart Optical Sensor for Near-infrared Fluorescence Imaging of Estrogen/Progesterone Receptor in Breast Cancer
Authors: Zhang Gong , Wang Zhe , Xia Yuke , Yu Han , Zhou Yu , zhang yunlei , Cui Yiyao 
Published: April 2022

Abstract
Background: Molecular-genetic imaging greatly advances clinical diagnosis and prognosis monitoring. However, specific visualization of cytoplasmic molecules remains an important but elusive goal. Estrogen receptor (ER) and progesterone receptor (PR) as the intracellular proteins and crucial markers of breast cancer determine the therapeutic regimes and prognosis of breast cancer patients. Methods: Here, we elegantly demonstrate that the ER/PR responsive elements can be genetically engineered to drive imaging reporters selectively and to enable the detection of ER/PR positive tumors using a far-red light photoactivatable near-infrared fluorescent protein. The specific molecular imaging probe were transfected into the cells and solid tumors using cationic polymers for lighting ER/PR breast cancers via a near-infrared fluorescence signal. Luciferase reporter system, ER/PR antagonist treatment, immunoblotting, and immunohistochemistry were performed to confirm the molecular mechanisms underlying the steroid receptor probe. Results: Notably, the double responsive elements of ER/PR exhibit the most response sensitivity to the steroid receptors in the breast cancers. By leveraging a cationic polymer vector, the construct consisting of optimal responsive elements and fluorescence protein can locally image the ER/PR positive breast cancers in murine models under a near-infrared laser, achieving non-invasive diagnosis of the steroid receptor positive cancers. No death or serious anaphylactic activity was observed in the animals during the study. Conclusion: As a result of its ER/PR specificity and potential for the clinical translation, the reporter system consisting of the steroid receptor response elements and near-infrared proteins might provide a novel practical system for identifying biomarkers, and advancing cancer diagnosis as well as therapy.
The Effects of Age, Physical Inactivity and Fatigue on Handgrip Strength Related Upper Extremity Functionality in Patients With Breast Cancer: a Mediation Analysis
Authors: Tuğral Alper , Bakar Yeşim , Akyol Murat 
Published: April 2022

Abstract
Purpose: This study was aimed to assess the effect of age, fatigue, self-reported function, and physical inactivity on handgrip strength related upper extremity function (HGSf) in breast cancer survivors (BCS). Secondarily, the potential mediator effects of fatigue and physical inactivity were also studied. This study was registered to Clinical Trials: NCT04245657.Methods: 111 female BCS (Mean age and BMI: 51.20±9.33 year and 27.86±3.70 kg/m2, respectively) were included in this study. Handgrip strength (HGS) was assessed with dynamometer while fatigue, self-reported upper extremity function and physical inactivity as sitting time were assessed with Fatigue Severity Scale (FSS), Disabilities of Arm, Shoulder and Hand Questionnaire (DASH), and 7th question of International Physical Activity Questionnaire Short Form, respectively. Results: HGS was found significantly higher on the right side compared to the left side (22.63±3.50 kgF vs 21.30±3.65 kgF, t=5.083, p<0.001). The mean sitting time, DASH and FSS were found 5.7 hours, 22.67 and 39.55, respectively. The multivariate linear regression analysis showed a total of 28% of the cumulative variance in HGSf is explained by age, DASH and sitting time variables (F (3,107) =12.057, p<0.001, R2=0.280). Fatigue was not found as a mediator in the hypothesized structural equation model while sitting time had a significant mediator effect between the age and HGSf (β=-0.004 (95% CI-0.075/-0.004), p=0.019)Conclusions: Increased physical inactivity and age play a major role in strength-related upper extremity function in BCS. Patient-specific physiotherapy programs should also consider this especially in older and physically BC patients in rehabilitation and long-term care.
Spatiotemporal Distribution Characteristics and Variations of Fog in Shandong Province, China from 2008-2019
Authors: Shu Weixi , Xiao Hui , Fu Danhong , Chang Bingsong , Feng Qiang , Shen Shujing , Yang Huiling 
Published: April 2022

Abstract
Fog has a significant effect on people's daily productivity and livelihood. The spatiotemporal distribution characteristics and variations of fog days and their impact factors in Shandong Province, China were explored by using diverse meteorological data. The results showed that the spatial distribution of fog days in Shandong province was consistent with the topographic characteristics. A few fog days region appeared a northeast-southwest trending zone in the central region, where was higher altitude topography, and more fog days on both sides can be found at lower altitude areas. Due to the effect of the topography, the water vapor transport and convergence played important roles in the spatial distribution of fog days. The annual number of fog days of different levels (light fog, dense fog, and extreme fog) in Shandong Province from 2008 to 2019 showed an increasing trend. The increase in water vapor, aggravation in air pollution, and decrease in wind speed had important effects on the increase of fog frequency. The fog frequencies in different months and seasons varied obviously, which related to the variations in LTS (lower-tropospheric stability) and wind speed in the lower layer. Fog occurred frequently within 00:00–08:00 during 2016–2019 in Shandong Province, and the diurnal variation in temperature was responsible for the diurnal variation in fog frequency. This research can serve as helpful references for the location and operation time of the work of artificial dissipating fog, and for traffic and airport safety management and control in Shandong Province.
Wool Wax, a Natural Product that Promote Olive growth by Auxin Production Enhancement
Authors: Aissani Nadhem , Ghidaoui Makrem 
Published: April 2022

Abstract
Effluents from textile industry using wool pose serious environmental nuisances that are mainly due to their pollutant load and the release of unpleasant odors. In order to minimize these hazards and to take advantage of these wastes for the sake of our environment, the present work consists on valuing wool wax from washing effluent on olive (Olea europea), one of the main agricultural products in Tunisia, germination and growth. The results showed that this waste is characterized by its richness in dry matter and total lipid content when we used water and hexan for washing with 60.7 and 95.6 % respectively. GCMS analysis of wax showed its richenes on fatty acids. Six saturated fatty acids ranking from 15 to 27 carbon atoms were characterized. Furthermore, diluted wax in water improves germination and growth of this plant. The best result was noted at 1.25 mg/g. GCMS analysis showed that slight enhancement in auxin production was noted in plants treated with 1.25 mg/g of wax with 0.9±0.1 ng/mg comparing to control (0.7± 0.2 ng/mg). This leads us to valuate wool wax as environmental frendly natural product in agricultural and fertigation practice.
Placental mesenchymal stem cells improve ovarian function in a rat model of premature ovarian insufficiency by inhibiting NLRP3 inflammasome activity
Authors: Ma Huiming , Hu Na , Xing Shasha , Liu Shudan , Guo Songlin , Zhang Feiyan , Ma Xiaona , Liang Xueyun , Chen Dongmei 
Published: April 2022

Abstract
Background
Premature ovarian insufficiency (POI) is a common clinical problem but there are currently no effective therapies. Pyroptosis induced by the NLRP3 inflammasome is considered a possible mechanism of POI. Placental mesenchymal stem cells (PMSCs) have excellent immunomodulatory potential and offer a promising method for treating POI.
Methods
Female Sprague–Dawley rats were randomly divided into four treatment groups: control (no POI), POI with no PMSCs, POI with PMSCs transplant, and POI with hormones (estrogen + progesterone) as positive control. POI was induced by exposure to 4-vinylcyclohexene diepoxide (VCD) for 15 days. After four weeks, all animals were euthanized and examined for pathology. Hormone levels were measured and ovarian function was evaluated in relation to the estrous cycle. Levels of NLRP3 inflammasome pathway proteins were determined by immunohistochemistry and western blot.
Results
VCD significantly damaged the rat follicles at different estrous stages. Injection of human PMSCs improved ovarian function and reproductive ability of POI rats compared to the sham and hormone groups. Our data also showed that PMSCs could remarkably suppress cell pyroptosis via downregulation of the NLRP3 inflammasome, caspase-1, IL-1β and IL-18 compared to the other two groups. The human PMSCs increased the expression of IL-4 and IL-10 and decreased pro-inflammatory factors.
Conclusions
Our findings revealed a novel mechanism of follicular dysfunction and ovarian fibrosis via activation of the NLRP3 inflammasome followed by secretion of pro-inflammatory factors. Transplantation of PMSCs into POI rats suppressed pro-inflammatory factor production, NLRP3 inflammasome formation and pyroptosis, and improved ovarian function.