bluuebunny/crossref_metadata_2025_split huggingface dataset:
A compass but not a road map: Diversity considerations with the AFCC Guidelines on Parenting Plan Evaluations
Authors: Harris‐Britt April 
Published: December 2022

AbstractThe 2022 Guidelines for Parenting Plan Evaluations in Family Law Cases were developed taking into account membership feedback which identified guidance around issues of Diversity Equity & Inclusion (DE&I) as a high priority. The current Guidelines have integrated issues of diversity in many areas of the document, by adding a section on guiding principles and values, expanding and clarifying evaluator education and training, and embedding cultural and diversity considerations in many sections of the document. The Guidelines do not provide more direct instruction or education on specific topics or aspects of culture and diversity.
Multi‐omics characterization of synthetic lethality‐related molecular features: implications for SL‐based therapeutic target screening
Authors: Weng Shenghui , Ruan Hang 
Published: December 2022

Synthetic lethality (SL) represents the co‐occurrence of two or more non‐lethal disordered genes that could lead to cell death. SL‐based anticancer therapeutics could specifically kill the cancer cells carrying the targeted mutated gene while leaving normal cells alive. Recent large‐scale computational and experimental screenings provide rich resources of SL information while lacking systematic research on molecular features of SL genes. Combined with comprehensive multi‐omics data analysis and experimental validation of one SL gene pair, Guo et al. portrayed a systematic layout of cancer‐specific SL interactions that could improve understanding of carcinogenesis and potentially assist the subsequent screening of anticancer therapeutic targets.
Revisiting attending to form during meaning comprehension in learning Spanish as an additional foreign language
Authors: Pan Junlan , Zhang Yuyang , Zhang Wen 
Published: December 2022

AbstractThe current replication study aims to examine the effects of learners' attention to lexical and grammatical forms on meaning comprehension while listening to a passage in Spanish. The registered protocol and materials in the aural mode from Morgan‐Short et al.'s (2018) multisite replication study were used, with first language (L1) Chinese–second language (L2) English participants (N = 122) learning Spanish as the third language (L3). The results partially reproduced the previous findings that there was no effect of attending to a lexical item (sol) on meaning comprehension. However, a small to medium effect was found on comprehension scores for simultaneously attending to a grammatical form (la). This finding reveals a site‐specific effect with learners from different L1 backgrounds, suggesting that learners' attending to a grammatical form absent in their L1 is detrimental to their meaning comprehension even if this form exists in their earlier learned L2.
Abundance trends for river macroinvertebrates vary across taxa, trophic group and river typology
Authors: Powell Kathryn E. , Oliver Tom H. , Johns Tim , González‐Suárez Manuela , England Judy , Roy David B. 
Published: December 2022

AbstractThere is mounting evidence that terrestrial arthropods are declining rapidly in many areas of the world. It is unclear whether freshwater invertebrates, which are key providers of ecosystem services, are also declining. We addressed this question by analysing a long‐term dataset of macroinvertebrate abundance collected from 2002 to 2019 across 5009 sampling sites in English rivers. Patterns varied markedly across taxonomic groups. Within trophic groups we detected increases in the abundance of carnivores by 19% and herbivores by 14.8%, while we estimated decomposers have declined by 21.7% in abundance since 2002. We also found heterogeneity in trends across rivers belonging to different typologies based on geological dominance and catchment altitude, with organic lowland rivers having generally higher rates of increase in abundance across taxa and trophic groups, with siliceous lowland rivers having the most declines. Our results reveal a complex picture of change in freshwater macroinvertebrate abundance between taxonomic groups, trophic levels and river typologies. Our analysis helps with identifying priority regions for action on potential environmental stressors where we discover macroinvertebrate abundance declines.
Soil phosphorus drawdown by perennial bioenergy cropping systems in the Midwestern US
Authors: Hussain Mir Zaman , Hamilton Stephen K. , Robertson G. Philip 
Published: December 2022

AbstractWithout fertilization, harvest of perennial bioenergy cropping systems diminishes soil nutrient stocks, yet the time course of nutrient drawdown has not often been investigated. We analyzed phosphorus (P) inputs (fertilization and atmospheric deposition) and outputs (harvest and leaching losses) over 7 years in three representative biomass crops—switchgrass (Panicum virgatum L.), miscanthus (Miscanthus × giganteus) and hybrid poplar trees (Populus nigra × P. maximowiczii)—as well as in no‐till corn (maize; Zea mays L.) for comparison, all planted on former cropland in SW Michigan, USA. Only corn received P fertilizer. Corn (grain and stover), switchgrass, and miscanthus were harvested annually, while poplar was harvested after 6 years. Soil test P (STP; Bray‐1 method) was measured in the upper 25 cm of soil annually. Harvest P removal was calculated from tissue P concentration and harvest yield (or annual woody biomass accrual in poplar). Leaching was estimated as total dissolved P concentration in soil solutions sampled beneath the rooting depth (1.25 m), combined with hydrological modeling. Fertilization and harvest were by far the dominant P budget terms for corn, and harvest P removal dominated the P budgets in switchgrass, miscanthus, and poplar, while atmospheric deposition and leaching losses were comparatively insignificant. Because of significant P removal by harvest, the P balances of switchgrass, miscanthus, and poplar were negative and corresponded with decreasing STP, whereas P fertilization compensated for the harvest P removal in corn, resulting in a positive P balance. Results indicate that perennial crop harvest without P fertilization removed legacy P from soils, and continued harvest will soon draw P down to limiting levels, even in soils once heavily P‐fertilized. Widespread cultivation of bioenergy crops may, therefore, alter P balances in agricultural landscapes, eventually requiring P fertilization, which could be supplied by P recovery from harvested biomass.
Dynein intermediate chains DYCI‐1 and WDR‐60 have specific functions in Caenorhabditis elegans
Authors: Higashida Maki , Niwa Shinsuke 
Published: December 2022

AbstractDynein is a microtubule‐dependent motor protein required for cell division, retrograde intracellular transport, and intraflagellar transport (IFT). Dynein 1 and dynein 2 serve as molecular motors in the cytoplasm and cilia, respectively. Each dynein consists of multiple subunits. Although the components of dynein 1 and dynein 2 are different and specific in most species, a previous study has suggested that dynein intermediate chain subunit DYCI‐1 is shared by both dynein 1 and 2 in Caenorhabditis elegans (C. elegans). Here, we show that C. elegans has two dynein intermediate chains—DYCI‐1 and WDR‐60—and their functions are different. Mutational analysis showed that dyci‐1 is essential for the retrograde axonal transport of synaptic vesicles. In the same mutant allele, IFT is not affected at all. Instead, wdr‐60 is essential for IFT. Thus, we suggest that dynein 1 and dynein 2 have specific intermediate chains in C. elegans as in other organisms.
Outcome of nucleos(t)ide analog cessation in patients with treatment for prevention of or against hepatitis B virus reactivation
Authors: Suzuki Takanori , Matsuura Kentaro , Urakabe Kenji , Okumura Fumihiro , Kawamura Hayato , Sobue Satoshi , Matoya Sho , Miyaki Tomokatsu , Kimura Yoshihide , Kato Daisuke , Kusakabe Atsunori , Tanaka Yoshito , Ozasa Atsushi , Nagura Yoshihito , Fujiwara Kei , Nojiri Shunsuke , Hagiwara Shinya , Kusumoto Shigeru , Inoue Takako , Tanaka Yasuhito , Kataoka Hiromi 
Published: December 2022

AbstractAimWe retrospectively investigated patients with administration of nucleos(t)ide analogs (NAs) for prevention of or against hepatitis B virus (HBV) reactivation, and their clinical outcomes after cessation of the NA.MethodsWe enrolled 180 patients who were positive for HBsAg when they started immunosuppressive therapy or chemotherapy and an NA was administered to prevent HBV reactivation (HBV carrier group), and 82 patients with resolved HBV infection who started administration of an NA after HBV reactivation (de novo HBV group). Cessation of the NA depended on each physician's judgment without definite criteria.ResultsA total of 27 patients in the HBV carrier group and 22 in the de novo HBV group stopped NA therapy. In the HBV carrier group, 16 patients experienced virological relapse, which was defined as HBV DNA levels ≥20 IU/ml, and one with hematological disease had an alanine aminotransferase flare after cessation of NA. Of the 16 patients, the NA was reintroduced in three, whereas, the remaining 13 had low levels of HBV DNA and no alanine aminotransferase flare. In the de novo HBV group, virological relapse occurred in six patients, and one with hematological disease had an alanine aminotransferase flare after cessation of the NA. The NA was reintroduced in four of the six patients.ConclusionsWe may be able to consider to cease NA therapy proactively in HBV carriers and resolved patients with non‐hematological disease, if their primary diseases are under remission after completion of immunosuppressive therapy or chemotherapy. However, careful follow up is necessary after stopping NA therapy.
Peripheral‐dominant liver fibrosis and tumor distribution in a mouse model of congestive hepatopathy
Authors: Kawai Hironari , Osawa Yosuke , Tsunoda Tomoyuki , Matsuda Michitaka , Okawara Miku , Sakamoto Yuzuru , Shimagaki Tomonari , Tsutsui Yuriko , Yoshida Yuichi , Yoshikawa Shiori , Doi Hiroyoshi , Mori Taizo , Yamazoe Taiji , Yoshio Sachiyo , Okamura Tadashi , Sugiyama Masaya , Okuzaki Daisuke , Komatsu Haruki , Inui Ayano , Yanaga Katsuhiko , Ikegami Toru , Kanto Tatsuya 
Published: December 2022

AbstractAimCongestive hepatopathy often leads to liver fibrosis and hepatocellular carcinoma. Imaging modalities provided clinical evidence that elevation of liver stiffness and tumor occurrence are mainly induced in the periphery of the liver in patients with congestive hepatopathy. However, clinical relevance of liver stiffness and liver fibrosis is unclear because liver congestion itself increases liver stiffness in congestive hepatopathy. It also unclear which factors configure such regional disparity of tumor development in patients with congestive hepatopathy. To answer these questions, we evaluated the macroscopic spatial distribution of liver fibrosis and tumors in the murine model of congestive hepatopathy.MethodsChronic liver congestion was induced by partial ligation of the suprahepatic inferior vena cava. Distribution of liver congestion, fibrosis, and tumors in partial ligation of the suprahepatic inferior vena cava mice were assessed by histological findings, laser microdissection (LMD)‐based qPCR and enhanced computed tomography. LMD‐based RNA‐sequencing was performed to identify causal factors that promote tumor development in congestive hepatopathy.ResultsLiver fibrosis was mainly induced in the periphery of the liver and co‐localized with distribution of liver congestion. Liver tumors were also induced in the periphery of the liver where liver congestion and fibrosis occurred. LMD‐based RNA‐sequencing revealed the upregulation of extracellular matrix/collagen fibril‐, wound healing‐, angiogenesis‐, morphogenesis‐, and cell motility‐related signaling pathways in periphery of liver compared with liver center.ConclusionsOur findings showed the experimental relevance of liver congestion, fibrosis, and tumor development in congestive hepatopathy, and may provide important locational information. Macroscopic regional disparity observed in this murine model should be considered to manage patients with congestive hepatopathy.
25‐Hydroxycholesterol induces odontoclastic differentiation through RANK–RANKL upregulation and NF‐κB activation in odontoblast‐like MDPC‐23 cells: An in vitro study
Authors: Lim HyangI , Oh Ji‐Su , Kang Kyeong‐Rok , Seo Jeong‐Yeon , Kim Do Kyung , Yu Sun‐Kyoung , Kim Heung‐Joong , Park Joo‐Cheol , Kim Jae‐Sung 
Published: December 2022

AbstractAimThe physiological effects and cellular mechanism of 25‐hydroxycholesterol (25‐HC), which is an oxysterol synthesized from cholesterol by cholesterol‐25‐hydroxylase (CH25H) expressed under inflammatory conditions, are still largely unknown during odontoclastogenesis. This study aimed to evaluate 25‐HC‐induced odontoclastogenesis and its cellular mechanisms in odontoblast‐like MDPC‐23 cells.MethodologyTo investigate 25‐HC‐induced odontoclastogenesis of MDPC‐23 cells and its cellular mechanism, haemotoxylin and eosin staining, tartrate‐resistant acid phosphatase (TRAP) staining, dentine resorption assay, zymography, reactive oxygen species (ROS) detection, immunocytochemistry, and nuclear translocation were performed. The experimental values are presented as mean ± standard deviation and were compared using analysis of variance, followed by post hoc multiple comparisons (Tukey's test) using SPSS software version 22 (IBM Corp.). A p‐value <.05 was considered statistically significant.ResultsLipopolysaccharide or receptor activator of nuclear factor‐κB ligand (RANKL) induced the synthesis of 25‐HC via the expression of CH25H in MDPC‐23 cells (p < .01). Multinucleated giant cells with morphological characteristics and TRAP activity of the odontoclast were increased by 25‐HC in MDPC‐23 cells (p < .01). Moreover, 25‐HC increased dentine resorption through the expression and activity of matrix metalloproteinases in MDPC‐23 cells. It not only increased the expression of odontoclastogenic biomarkers but also translocated cytosolic nuclear factor‐κB (NF‐κB) to the nucleus in MDPC‐23 cells. Additionally, 25‐HC not only increased the production of ROS (p < .01), expression of inflammatory mediators (p < .01), pro‐inflammatory cytokines, receptor activator of NF‐κB (RANK), and RANKL but also suppressed the expression of osteoprotegerin (OPG) in MDPC‐23 cells. In contrast, CDDO‐Me, a chemical NF‐κB inhibitor, decreased TRAP activity (p < .01) and downregulated the expression of the odontoclastogenic biomarkers, including RANK and RANKL, in MDPC‐23 cells.Conclusion25‐HC induced odontoclastogenesis by modulating the RANK–RANKL–OPG axis via NF‐κB activation in MDPC‐23 cells. Therefore, these findings provide that 25‐HC derived from cholesterol metabolism may be involved in the pathophysiological etiological factors of internal tooth resorption.
Prevalence of smoking among nurses and its association with blood pressure: A cross‐sectional study in 11 cities of China
Authors: Zhao Bin , Li Jing , Zhang Luqi , Liu Jie , Feng Di , Hao Xiaoran , Li Yun , Li Xian , Ding Junqin , Li Laiyou , Li Lanfeng , Yin Xiaohua , Cui Wei 
Published: December 2022

AbstractAimSmoking is harmful to human health. However, the relationship between smoking and blood pressure (BP) has not been consistent. This study aimed to analyse nurses' smoking behaviours and their relationship with BP.MethodsThis cross‐sectional study recruited 128 009 nurses in 11 cities in China. They were surveyed with questionnaires including BP measurements. The main contents of the questionnaire included smoking status and other factors that might be associated with hypertension. Multiple linear regression analyses and binary logistic regression analyses were used to analyse the data.ResultsThe results showed there was a significant difference in the smoking rate among nurses with different characteristics (P < 0.05). For both male and female nurses, smoking was associated with increased diastolic BP and mean arterial pressure, but only with increased systolic BP of male nurses. The prevalence of hypertension among male and female nurses was not related to smoking.ConclusionDespite a relatively low overall smoking rate, rates among some groups are high. Different cities, hospitals, and departments can combine local data and conditions to formulate targeted tobacco control measures to improve nurses' physical and mental health.
Factors influencing intrapartum health outcomes among Black birthing persons: A discursive paper
Authors: Gillette‐Pierce Kiersten TâLeigh , Richards‐McDonald Lynn , Arscott Joyell , Josiah Nia , Duroseau Brenice , Jacques Keilah , Wilson Patty R. , Baptiste Diana 
Published: December 2022

AbstractAimTo examine factors that influence intrapartum health outcomes among Black childbearing persons, including cisgender women, transmasculine and gender‐diverse birthing persons.BackgroundBlack childbearing persons are three to four times (243%) more likely to die while giving birth than any other racial/ethnic group. Black birthing persons are not just dying from complications but also from inequitable care from healthcare providers compared to their white counterparts.DesignDiscursive paper.MethodSearching national literature published between 2010 and 2021 in PubMed, CINAHL, Embase and SCOPUS, we explored factors associated with poor intrapartum health outcomes among Black childbearing persons.DiscussionSeveral studies have ruled out social determinants of health as sufficient causative factors for poor intrapartum health outcomes among Black birthing persons. Recent research has shown that discrimination by race heavily influences whether a birthing person dies while childbearing.ConclusionsThere is a historical context for obstetric medicine that includes harmful stereotypes, implicit bias and racism, all having a negative impact on intrapartum health outcomes. The existing health disparity among this population is endemic and requires close attention.Impact on Nursing PracticeNurses and other healthcare professionals must understand their role in establishing unbiased care that promotes respect for diversity, equity and inclusion.No Patient or Public ContributionThere was no patient or public involvement in the design or drafting of this discursive paper.
Energetic music is used for anger downregulation: A cross‐cultural differentiation of intensity from rhythmic arousal
Authors: Liew Kongmeng , Uchida Yukiko , Domae Hiina , Koh Alethea H. Q. 
Published: December 2022

AbstractMusic is often used to “soothe the soul,” and one important function of music listening has been emotion regulation. In comparing consumption trends across cultures, past research has shown that individuals in Western countries, with typically higher prevalence of high arousal negative emotions, tend to listen to similarly high arousal rhythmic (danceable) music to cathartically discharge those emotions. However, other studies have shown that Spotify's energy feature, a measure of the intensity‐based arousal of a song, indicates the opposite effect: Energy was higher in songs in East Asian top‐50 charts than in Western ones. Combining evidence from reanalyses of secondary data (Pilot Analyses 1 and 2), sentiment analyses of lyrics from the US and Singapore (Study 1; N = 87 songs), and an emotion induction experiment in Japan and the US (Study 2; N = 353 participants), we show that collectivistic, East Asian cultures generally prefer songs with higher energy levels, and energetic songs are robustly associated with anger downregulation, over sadness and anxiety downregulation. We speculate that energy, as an intensity‐based musical arousal feature, may represent internalizing (control) regulation that one uses to “drown out” anger, which would be more prevalent in East Asian cultures due to sociocultural norms of emotion (non)expression. Conversely, this would be different from the externalizing regulation associated with rhythm‐based musical arousal (i.e., danceability).
Estimating farmers' intention towards institutional credit adoption by using extended theory of planned behavior
Authors: Dey Shiladitya , Singh Piyush Kumar 
Published: December 2022

AbstractThe role of socio‐psychological factors on farmers' institutional credit adoption intention is rarely studied in the context of developing nations. This study estimates the direct and mediating association of various socio‐psychological factors with farmers' institutional credit adoption intention. An extended theory of planned behavior (TPB) was adopted and empirically tested using the cross‐sectional data from 384 farmers from West Bengal. The study used structural equation model for the mediation analysis. Results showed that primary TPB constructs like attitude, subjective norm, and perceived behavioral control were positively and significantly associated with the intention of institutional credit adoption. Besides direct effect, the primary TPB constructs mediated the relationship between institutional credit adoption intention and other explanatory constructs used in this study. Findings predicted a positive partial mediation between trusted information sources, formal education level, coping appraisal, risk perception, and farmers' formal credit borrowing intention. Risk perception displayed a direct and mediated, however, negative, association with farmers' institutional credit adoption intention. These findings provide a clear understanding of factors predicting farmers' intention to adopt institutional credit and comprehensive insight into establishing policies for effective institutional lending at the ground level. The study delivers a paramount scientific perspective to the policymaker of developing countries suffering from insufficient institutional credit penetration in the farming community to design practicable frameworks and incentivize policies to motivate farmers in institutional credit borrowing.