bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of sous vide cooking combined with ultrasound pretreatment on physicochemical properties and microbial communities of Russian sturgeon meat (Acipenser gueldenstaedti)
Authors: Yuan Yan‐wei , Cai Wen‐qiang , Wang Meng‐zhen , Liu Yu‐ting , Fu Jing‐jing , Chen Yue‐wen 
Published: December 2022

AbstractBACKGROUNDThe production of Russian sturgeon is expanding rapidly in China but it is necessary to adopt measures to extend the shelf life of sturgeon meat. Previous studies found that sous vide cooking (SVC) at 60 °C increased the protein and lipid oxidation. The addition of antioxidant substances reduced the acceptance of the product. The effect of combination SVC and ultrasound pretreatment was therefore investigated.RESULTSResults showed that SVC at 50 °C combined with ultrasound effectively restrained the growth of total viable counts (TVC) in samples. Meanwhile, the main dominant genera changed from Pseudomonas to Carnobacterium and the number of microbial species decreased. The odor profile of Russian sturgeon meat was more stable and the lipoxygenase (LOX) activity decreased more rapidly after treating with SVC and ultrasound. Importantly, more stable protein aggregates were formed in samples treated by SVC 50 °C together with ultrasound pretreatment, so the protein and lipid oxidation were slowed during storage. Higher springiness values were obtained and the color of sturgeon meat was lighter under these conditions.CONCLUSIONThe combination of SVC 50 °C and ultrasound pretreatment effectively inhibited the microbial growth of Russian sturgeon meat at lower oxidation levels. These findings theoretically support the preservation and development of sturgeon meat, and the application of SVC technology. © 2022 Society of Chemical Industry.
Imaging Cloaked Objects: Diffraction Tomography of Realistic Invisibility Devices
Authors: Díaz‐Fernández Francisco J. , Martí Javier , García‐Meca Carlos 
Published: December 2022

AbstractInvisibility cloaks have become one of the most outstanding developments among the wide range of applications in the field of metamaterials. So far, most efforts in invisibility science have been devoted to achieving practically realizable cloak designs and to improving the effectiveness of these devices in reducing their scattering cross‐section (SCS), a scalar quantity accounting for the total electromagnetic energy scattered by an object. However, little attention has been paid to the opposite side of the technology: the development of more efficient techniques for the detection of invisibility devices. For instance, the SCS ignores the phase change introduced by the cloak, as well as the angular dependence of the incident and scattered waves. Here, a different path is proposed, which takes advantage of the smarter way in which diffraction tomography processes all this overlooked information to improve the efficiency in unveiling the presence of invisibility devices. This approach not only results in a considerable sensitivity enhancement in the detection of different kinds of cloaks based on both scattering cancellation and transformation optics, but also enables us to obtain images depicting the approximate shape and size of the cloak. The proposed method can be extended to the detection of sound cloaks.
Exotic Photonic Spin Hall Effect from a Chiral Interface
Authors: Sheng Lijuan , Zhou Xinxing , Zhong Yuhan , Zhang Xinyan , Chen Yu , Zhang Zhiyou , Chen Hongsheng , Lin Xiao 
Published: December 2022

AbstractThe photonic spin Hall effect provides a quantitative way to characterize the spin–orbit interaction of light and enables many applications, such as the precise metrology, since this effect is featured with a spin‐dependent transverse shift of the light beam. This transverse shift is generally nonzero during the reflection/transmission process, and it is sensitive to the polarization and the incident angle of the light beam. By contrast, here it is revealed that for the transmitted light, the transverse shift can be always zero and polarization‐independent, irrespective of the incident angle. The underlying mechanism is that the conversion between the spin and orbit angular momenta of light is fully suppressed during the transmission process. Such an exotic photonic spin Hall effect occurs, if , , and , where t stands for the transmission coefficient and its first (second) superscript represents the polarization of the transmitted (incident) light, and () is the transmitted (incident) angle. These transmission conditions are achievable, e.g., by exploiting an interface only with a chiral surface conductivity. Similarly, a polarization‐independent photonic spin Hall effect is revealed for the reflected light.
Maximally Chiral Emission via Chiral Quasibound States in the Continuum
Authors: Lim Yeonsoo , Seo In Cheol , An Soo‐Chan , Kim Younggon , Park Chaejin , Woo Byung Hoon , Kim Seongheon , Park Hyeong‐Ryeol , Jun Young Chul 
Published: December 2022

AbstractAlthough numerous natural materials exhibit chiral optical phenomena, they are typically very weak. Chiral nanophotonic structures can significantly enhance the chiroptical responses and provide unprecedented design flexibility. However, achieving extreme chirality that approaches the ultimate theoretical limit remains challenging. Here, chiral quasibound states in the continuum are realized in the visible range, and maximally chiral emission from a perovskite metasurface is demonstrated. A perovskite film is spin‐coated on a patterned glass substrate. Grayscale lithography is employed to control the etching depths in the substrate and induce out‐of‐plane symmetry breaking. An extremely high level of chiral emission is experimentally achieved in the normal direction at room temperature. Chiral emission is maximally enhanced for one helicity via critical coupling, while strongly suppressed for the other helicity. The physical mechanism is explained using the reciprocity principle. Approaching the ultimate limit of chiral responses may lead to far‐reaching consequences in various important applications as well as fundamental studies.
Evaluation of Biocompatible Films Using Copolymers of N‐Vinylbenzamide with Cationic Moieties by Hydrolysis of N‐Vinylformamide
Authors: Kawatani Ryo , Hamawaki Taiga , Waku Tomonori , Tanaka Naoki , Ajiro Hiroharu 
Published: December 2022

AbstractBiocompatible materials using poly(N‐vinylamide) derivatives are developed via a recently designed synthetic route. N‐Vinylbenzamide (NVB) is synthesized as typical hydrophilic N‐vinylamide monomer, then copolymerized with N‐vinylformamide (NVF) by free radical polymerization, which can convert to cationic polyvinylamine unit by hydrolysis. Cell toxicity on the surface of copolymer films is investigated, revealing that poly(N‐vinylamide) derivatives show biocompatibility regardless of the cationic ratio.
Programmable Thermo‐Responsive Actuation of Hydrogels via Light‐Guided Surface Growth of Active Layers on Shape Memory Substrates
Authors: Fan Guang‐Lin , Wang Shu‐Wei , Zhang Ying‐Ying , Liu Zhao‐Tie , Liu Zhong‐Wen , Wang Lei , Jiang Jin‐Qiang , Li Guo 
Published: December 2022

AbstractHydrogel shape memory and actuating functionalities are heavily pursued and have found great potential in various application fields. However, their combination for more flexible and complicated morphing behaviors is still challenging. Herein, it is reported that by controlling the light‐initiated polymerization of active hydrogel layers on shape memory hydrogel substrates, advanced morphing behaviors based on programmable hydrogel shapes and actuating trajectories are realized. The formation and photo‐reduction‐induced dissociation of Fe3+‐carboxylate coordination endow the hydrogel substrates with the shape memory functionality. The photo‐reduced Fe2+ ions can diffuse from the substrates into the monomer solutions to initiate the polymerization of the thermally responsive active layers, whose actuating temperatures and amplitudes can be facially tuned by controlling their thicknesses and compositions. One potential application, a shape‐programmable 3D hook that can lift an object with a specific shape, is also unveiled. The demonstrated strategy is extendable to other hydrogel systems to realize more versatile and complicated actuating behaviors.
Further characterization of the 9q31 microdeletion phenotype; delineation of a common region of overlap containing ZNF462
Authors: Brady Lauren , Ballantyne Mark , Duck John , Fisker Thomas , Kleefman Ryan , Li Chumei , Nfonsam Landry , Schultz Lee‐Anne , Tarnopolsky Mark , McCready Elizabeth 
Published: December 2022

AbstractBackgroundLoss of function variants and whole gene deletions of ZNF462 has been associated with a novel phenotype of developmental delay/intellectual disability and distinctive facial features. Over two dozen cases have been reported to date and the condition is now known as Weiss‐Kruszka syndrome (OMIM# 618619). There are several older reports in the literature and DECIPER detailing individuals with interstitial deletions of 9q31 involving the ZNF462 gene. Many of the characteristic facial features described in these microdeletion cases are similar to those who have been diagnosed with Weiss‐Kruszka syndrome.MethodsWe describe three additional patients with overlapping 9q31 deletions and compare the phenotypes of the microdeletion cases reported in the literature to Weiss‐Kruszka syndrome.ResultsPhenotypic overlap was observed between patients with 9q31 deletions and Weiss‐Kruszka syndrome. Several additional features were noted in 9q31 deletion patients, including hearing loss, small head circumference, palate abnormalities and short stature.ConclusionsThe common region of overlap of microdeletion cases implicates ZNF462 as the main driver of the recognizable 9q31 microdeletion phenotype. The observation of additional features in patients with 9q31 microdeletions that are not reported in Weiss‐Kruszka syndrome further suggests that other genes from the 9q31 region likely act synergistically with ZNF462 to affect phenotypic expression.
Artificial neural network models driven novel virtual screening workflow for the identification and biological evaluation of BACE1 inhibitors
Authors: Kashyap Kushagra , Panigrahi Lalita , Ahmed Shakil , Siddiqi Mohammad Imran 
Published: December 2022

AbstractBeta‐site amyloid‐β precursor protein‐cleaving enzyme 1 (BACE1) is a transmembrane aspartic protease and has shown potential as a possible therapeutic target for Alzheimer's disease. This aggravating disease involves the aberrant production of β amyloid plaques by BACE1 which catalyzes the rate‐limiting step by cleaving the amyloid precursor protein (APP), generating the neurotoxic amyloid β protein that aggregates to form plaques leading to neurodegeneration. Therefore, it is indispensable to inhibit BACE1, thus modulating the APP processing. In this study, we present a workflow that utilizes a multi‐stage virtual screening protocol for identifying potential BACE1 inhibitors by employing multiple artificial neural network‐based models. Collectively, all the hyperparameter tuned models were assigned a task to virtually screen Maybridge library, thus yielding a consensus of 41 hits. The majority of these hits exhibited optimal pharmacokinetic properties confirmed by high central nervous system multiparameter optimization (CNS‐MPO) scores. Further shortlisting of 8 compounds by molecular docking into the active site of BACE1 and their subsequent in‐vitro evaluation identified 4 compounds as potent BACE1 inhibitors with IC50 values falling in the range 0.028–0.052 μM and can be further optimized with medicinal chemistry efforts to improve their activity.
A miniaturized ultra‐wideband filter with ultra‐wide stopband and high selectivity using a capacitive loading stub in a multimode structure
Authors: Liu Zhi‐Hao , Liu Bao‐Guang , Wang Yu‐Chen , Cheng Chong‐Hu 
Published: December 2022

AbstractIn this paper, a miniaturized ultra‐wideband filter with ultra‐wide stopband and high selectivity using a capacitive loading stub in a multimode structure is proposed. The second, third, and fourth harmonics of the proposed filter are all suppressed on account of using a capacitive loading stub, which makes it have the characteristic of an ultra‐wide stopband. In addition, there are two transmission zeros located at the upper stopband close to the passband, which improves the selectivity of the proposed filter. The proposed filter is fabricated and measured, and the result shows the filter with the center frequency f0 1.185 GHz has 151% 3‐dB fractional bandwidth. Its upper stopband is extended to 9.18 GHz (7.75 f0) and the 20‐dB roll off rate is 212.5 dB/GHz. What's more, the size of the proposed filter is 0.175 λg × 0.18 λg, where λg is the guided wavelength at the center frequency f0.
Design of planar wideband surface‐wave excited substrate integrated waveguide horn antenna loaded with metamaterials
Authors: Cai Yang , Han Wenting , Song Wenke , Li Sen , Cao Yufan 
Published: December 2022

AbstractIn this paper, a wideband planar substrate integrated waveguide (SIW) horn antenna based on surface wave excitation through loading metamaterials is designed. Strong coupling effect is realized between the employed bilayer metamaterial unit with the top layer as a π‐shaped‐slotted patch while the bottom layer as the complementary cross‐shaped‐slotted patch. The equivalent permittivity of the extended substrate in front of the planar horn aperture can be effectively reduced to unity and impedance mismatching for conventional planar SIW horn antenna can be reduced in a wide bandwidth. Results indicate that the working frequency of the antenna is 12.3–15.8 GHz with the relative impedance bandwidth of 24.6%.
Q‐factor enhanced resonator biosensor optimized by adaptive genetic algorithm for glucose detection
Authors: Xie Bingfang , Wang Cong , Meng Fanyi , Li Xiao , Wu Qun 
Published: December 2022

AbstractThis paper presents three devices of biosensors for glucose concentrations. A resonator based on the defected ground structure (DGS) was designed and the optimizations for the single square and both squares of the DGS via adaptive genetic algorithm were applied to enhance the performance of the sensors including the Q‐factor and the electric field distribution. The fabricated devices of the best optimized one exhibited an enhanced Q‐factor of 442 and a sensitivity of 142.2 MHz/mgml−1, which is more than 2.37 times than the basic structure.
Wideband filtering phase shifters using vertically installed planar structure
Authors: Dai Yong , Wang Da‐Yang , Jiang Song , Liu Lei 
Published: December 2022

AbstractIn this letter, A wideband filtering phase shifter is proposed based on vertically installed planar (VIP) circuit structures, where the VIP circuit is used to realize a tight coupling. The even‐odd mode analysis is adopted to analyze the whole structure. Then, a 45° filtering phase shifter is designed to verify the validity of the design methodology. The simulated and measured results demonstrate that the proposed phase shifter has low insertion losses (<0.5 dB) and excellent return losses (<−15 dB). The 3°‐phase shift bandwidth is more than 64.31%.
‘Optimal’ cutoff selection in studies of depression screening tool accuracy using the PHQ‐9, EPDS, or HADS‐D: A meta‐research study
Authors: Brehaut Eliana , Neupane Dipika , Levis Brooke , Wu Yin , Sun Ying , Ioannidis John P. A. , Markham Sarah , Cuijpers Pim , Patten Scott B. , Benedetti Andrea , Thombs Brett D. 
Published: December 2022

AbstractObjectivesOptimal cutoff thresholds are selected to separate ‘positive’ from ‘negative’ screening results. We evaluated how depression screening tool studies select optimal cutoffs.MethodsWe included studies from previously conducted meta‐analyses of Patient Health Questionnaire‐9, Edinburgh Postnatal Depression Scale, or Hospital Anxiety and Depression Scale—Depression accuracy. Outcomes included whether an optimal cutoff was selected, method used, recommendations made, and reporting guideline and protocol citation.ResultsOf 212 included studies, 172 (81%) attempted to identify an optimal cutoff, and 147 of these 172 (85%) reported one or more methods. Methods were heterogeneous with Youden's J (N = 35, 23%) most common. Only 23 of 147 (16%) studies described a rationale for their method. Rationales focused on balancing sensitivity and specificity without describing why desirable. 131 of 172 studies (76%) identified an optimal cutoff other than the standard; most did not make use recommendations (N = 56; 43%) or recommended using a non‐standard cutoff (N = 53; 40%). Only 4 studies cited a reporting guideline, and 4 described a protocol with optimal cutoff selection methods, but none used the protocol method in the published study.ConclusionsResearch is needed to guide how selection of cutoffs for depression screening tools can be standardized and reflect clinical considerations.
Targeting peptide‐mediated interactions in omics
Authors: Lin Jing , Wang Shaozhou , Wen Li , Ye Haiyang , Shang Shuyong , Li Juelin , Shu Jianping , Zhou Peng 
Published: December 2022

AbstractPeptide‐mediated interactions (PMIs) play a crucial role in cell signaling network, which are responsible for about half of cellular protein–protein associations in the human interactome and have recently been recognized as a new kind of promising druggable target for drug development and disease therapy. In this article, we give a systematic review regarding the proteome‐wide discovery of PMIs and targeting druggable PMIs (dPMIs) with chemical drugs, self‐inhibitory peptides (SIPs) and protein agents, particularly focusing on their implications and applications for therapeutic purpose in omics. We also introduce computational peptidology strategies used to model, analyze, and design PMI‐targeted molecular entities and further extend the concepts of protein context, direct/indirect readout, and enthalpy/entropy effect involved in PMIs. Current issues and future perspective on this topic are discussed. There is still a long way to go before establishment of efficient therapeutic strategies to target PMIs on the omics scale.
Extinction risk to the endemic trees of Papua New Guinea
Authors: Barstow Megan , Jimbo Tiberius , Davies Katharine 
Published: December 2022

Societal Impact StatementPapua New Guinea has a diverse tree flora. Now for the first time we know that 460 (36%) of its endemic tree species are threatened with extinction in the wild. These trees require immediate conservation action, through a variety of methods. Protection of trees is essential in Papua New Guinea as many people across the country rely on them for their livelihoods. Additionally, the extinction of these species would mean the loss of unique biodiversity. With the majority of forest cover still remaining in Papua New Guinea, it presents an almost unique opportunity to save tree diversity at a large scale and should therefore be at the forefront of the conservation agenda.Summary

Papua New Guinea is one of the world's most tree diverse countries, with over 1,200 endemic tree species. However, forests within the country face a range of threats but the impact of these threats on individual tree species has yet to be studied. Without identifying which species are threatened, where they are and their major threats it is not possible to effectively prioritise conservation actions for the trees of Papua New Guinea.
The Global Tree Assessment for Papua New Guinea produced International Union for Conservation of Nature (IUCN) Red List assessments for over 90% of tree species endemic to Papua New Guinea. The assessments compiled information on extinction risk, major threats, conservation and research needs for the country's tree flora.
Four hundred and sixty tree species are threatened with extinction, including 143 Critically Endangered species. This is 36% of the country's endemic tree flora. The majority of tree species are threatened by annual‐perennial non‐timber crop farming, logging and establishment of wood and pulp plantations. The change in land use instigated by these threats causes lowland tropical/sub‐tropical forest to be the most threatened habitat types for trees.
To protect Papua New Guinea's diverse tree flora, a range of conservation activities are required. Both in situ and ex situ conservation efforts, which are species specific, are needed and activities should be supported on a local, national and international level with continued and expanded collaboration between international NGOs and botanists and specialists working in Papua New Guinea.
Endothelial β‐arrestins regulate mechanotransduction by the type II bone morphogenetic protein receptor in primary cilia
Authors: Park Saejeong , Ma Zhiyuan , Zarkada Georgia , Papangeli Irinna , Paluri Sarin , Nazo Nour , Rivera‐Molina Felix , Toomre Derek , Rajagopal Sudarshan , Chun Hyung J. 
Published: December 2022

AbstractModulation of endothelial cell behavior and phenotype by hemodynamic forces involves many signaling components, including cell surface receptors, intracellular signaling intermediaries, transcription factors, and epigenetic elements. Many of the signaling mechanisms that underlie mechanotransduction by endothelial cells are inadequately defined. Here we sought to better understand how β‐arrestins, intracellular proteins that regulate agonist‐mediated desensitization and integration of signaling by transmembrane receptors, may be involved in the endothelial cell response to shear stress. We performed both in vitro studies with primary endothelial cells subjected to β‐arrestin knockdown, and in vivo studies using mice with endothelial specific deletion of β‐arrestin 1 and β‐arrestin 2. We found that β‐arrestins are localized to primary cilia in endothelial cells, which are present in subpopulations of endothelial cells in relatively low shear states. Recruitment of β‐arrestins to cilia involved its interaction with IFT81, a component of the flagellar transport protein complex in the cilia. β‐arrestin knockdown led to marked reduction in shear stress response, including induction of NOS3 expression. Within the cilia, β‐arrestins were found to associate with the type II bone morphogenetic protein receptor (BMPR‐II), whose disruption similarly led to an impaired endothelial shear response. β‐arrestins also regulated Smad transcription factor phosphorylation by BMPR‐II. Mice with endothelial specific deletion of β‐arrestin 1 and β‐arrestin 2 were found to have impaired retinal angiogenesis. In conclusion, we have identified a novel role for endothelial β‐arrestins as key transducers of ciliary mechanotransduction that play a central role in shear signaling by BMPR‐II and contribute to vascular development.