bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of adjunctive low-frequency repetitive transcranial magnetic stimulation therapy over the left dorsolateral prefrontal cortex in patients with obsessive-compulsive disorder refractory to medical treatment: a double-blind, randomized clinical trial
Authors: Jahanbakhsh Ghazal , Hajseyedjavadi Alireza , Majidi Mahnaz 
Published: February 2022

Abstract

Background: Obsessive-compulsive disorder (OCD) is a common mental illness. The Food and Drug Administration (FDA) approved repetitive transcranial magnetic stimulation (rMS) to treat OCD in 2018. So far, various approaches have been evaluated. We evaluated the effect of adjunctive low-frequency rMS over the left dorsolateral prefrontal cortex in patients with OCD refractory to treatment. Methods: The present clinical trial was done on 30 patients with OCD referring from the psychiatry clinic, 22 Bahman Hospital, Qazvin province, between 2018 and 2020 and patients were randomly divided into two groups. The intervention group received rTMS treatment at 1 Hz for 20 min (1200 pulses/day) over the left DLPFC area as adjunctive to the medical treatment three times a week and for five weeks, whereas those in the control group were subjected to only the sham condition plus their medical treatment. The Yale-Brown Obsessive-Compulsive Scale (y-BOC.S) was completed by patients before the study, following sessions 5 and 10 during the intervention, at the end of the intervention, and three to six months after the intervention under the direct supervision of a psychiatrist. SPSS software version 26 was used to compare the results between the two groups. Results: The intervention group showed significantly lower mean Y-BOCS scores after the intervention and at follow-up (P <0.05) and all patients of the intervention group showed significantly lower Y-BOCS scores than their own baseline scores (P <0.05). Also, using antipsychotic agents along with the serotonergic agents caused significantly lower scores in the intervention group at the end of the intervention (P <0.05). All the patients were found with higher follow-up scores than their scores at the end of the intervention; however, this difference was not significant (p>0.05). Conclusion: Adjunctive low-frequency (1 Hz) rTMS over the left DLPFC is able to effectively reduce Y-BOCS score in OCD patients refractory to treatment following 15 sessions, and the reduction was durable even after three to six months. Using antipsychotic agents as an adjuvant with serotonergic agents was identified as a possible predictor for response to adjunctive rTMS therapy.
Intraoperative Hemodialysis During Open-Heart Surgery in Patients With Severe Chronic Kidney Disease
Authors: Inoue Takahiro , Kuji Hiroshi , Nagaoka Kanako , Akanuma Takafumi , Fukuda Junko , Matsui Hiroki , Tanabe Hiroaki , Ohara Mamiko , Suzuki Tomo 
Published: February 2022

Abstract
Background:Acute kidney injury and chronic kidney disease (CKD) after cardiac surgery are associated with increased mortality and renal prognosis. We evaluated the utility of intraoperative hemodialysis (IHD) during open-heart surgery of patients with severe CKD.Methods:The present study was a single-center retrospective cohort study employing IHD for non-emergency open-heart surgery in patients with CKD G4 or G5. We compared the patients in IHD group with those in the non-IHD group retrospectively. Primary outcomes were 30-day mortality and initiation of renal replacement therapy (RRT) after surgery.Results:Twenty-eight patients were categorized into the IHD group and 33 into the non-IHD group. Comparing the IHD versus the non-IHD, men accounted for 60.7 vs. 50.3%, the age was mean 74.5 (SD 7.0) vs. 72.9 (SD 9.4) years (p=0.744), and the rate of CKD G4 patients was 67.9 % vs. 84.8 %. On the other hand, preoperative estimated glomerular filtration rate of the IHD is significantly lower than the non-IHD (19.1 ± 5.6 vs. 22.0 ± 5.2 ml/min/1.73 m2, p=0.039). For clinical outcomes, no significant differences were observed in 90-day mortality (7.1 vs. 3.0 %, p=0.482) and 30-day RRT rate (17.9 vs 30.3%, p=0.261). In the patients with CKD G4, the 30-day RRT rate was significantly lower in patients in the IHD than in those in the non-IHD (0 vs. 25.0%, p=0.037). Conclusions:IHD during open-heart surgery reduced the incidence of postoperative dialysis in patients with CKD G4 and may be useful for postoperative management.
Genome-wide identification of DNA polymorphism in salt-tolerant and sensitive rice genotypes using double digest RADseq
Authors: Tariq Rida , Arif Muhammad , Zhang Hong-Bin , ALI JAUHAR 
Published: February 2022

Abstract
Salt-tolerant rice varietal development is necessary and the best approach to enhance crop productivity in areas with high salinity. To identify the genetic variation in stress-related genes in salt-tolerant genotypes, we carried out genotyping by sequencing (GBS) of seven rice lines with contrasting responses to salinity stress, including FL478 as a tolerant variety and IR64 as a sensitive check. The GBS reduces genomic complexity and enables us to obtain many SNP markers in the genome. A total of 7,980,092 high-quality single-end reads of 94 bp each were generated, and approximately 83% of the reads mapped to the rice reference genome (Nipponbare). We identified a total of 80,159 SNPs and 6,403 InDels among the seven rice genotypes. Forty-two percent of these SNPs were identified from the genic regions, and further, 27% were observed in the coding areas out of these genic SNPs. We used bioinformatics analysis to identify functional SNPs in the genes that changed the functions of proteins. We found variations between tolerant and sensitive genotypes by comparing the identified SNPs in coding regions. We found that 566 of the SNPs identified in the coding regions were non-synonymous (nsSNPs), affecting proteins. We identified 116 abiotic stress-related genes that contained 138 nsSNPs (between FL478 and IR64) in coding regions, thus directly affecting the proteins. Analysis indicated that these genes might contribute to the salt stress phenotype in rice varieties and the identified nsSNP markers that were useful to distinguish tolerant and sensitive genotypes. Our results revealed that the identified SNPs could be used as an essential source of genomic variability for improving and developing saline tolerant genotypes.
Induction of Pyroptosis in Renal Tubular Epithelial Cells Using High Glucose
Authors: Yuan Fang , He Mingyue , Xiong Hao , Liu Yinghong 
Published: February 2022

Abstract
Background: The micro-inflammatory state is important for the occurrence of diabetic kidney disease (DKD). Here, we aimed to explore the expression of pyroptosis related indicators and ultrastructural characteristics in DKD ,to investigate pyroptosis in renal tubular epithelial cells induced by high glucose.Methods: Immunohistochemistry was used to detect expression of the inflammation-related protein NOD-like receptor protein 3 (NLRP3) and pyroptosis key protein gasmedermin D (GSDMD) in kidney tissues of DKD patients. HK-2 cells were cultured in vitro and stimulated with different concentrations of glucose .The changes in HK-2 cell ultrastructure were observed using electronmicroscopy, and western blotting was used to detect NLRP3, caspase-1 p20, GSDMD-N, interleukin (IL)-1β, and IL-18 expression. Results: NLRP3 and GSDMD expression in kidney tissues of DKD patients was higher than that in control subjects.Further, GSDMD expression was positively correlated with that of NLRP3 (r = 0.847, P = 0.02). After stimulating HK-2 cells for 24 h with different glucose concentrations, compared with the control group, the 15 mmol/L and 30 mmol/L glucose groups showed typical ultrastructural changes of pyroptosis. The protein expression of NLRP3, caspase-1 p20, GSDMD-N, IL-1β, and IL-18 expression in high glucose increased significantly compared with the control group, and was glucose-concentration-dependent. Conclusion: High glucose can activate inflammasome , cause inflammatory cytokines release, and induce pyroptosis in HK-2 cells . NLRP3-caspase-1 may be involved in GSDMD-mediated pyroptosis. This study shows a novel relationship between glucose concentration and pyroptosis, which can be studied further to design better therapies for patients with DKD.
Evaluation of Serum Biochemical Parameters and Metabolism in Smokers: A Case Control Study
Authors: Sezgin Yılmaz 
Published: February 2022

Abstract
Background

Smoking tobacco is a substantial risk factor for chronic obstructive pulmonary disease and cardiovascular diseases. For this reason, studies on smoking are mostly focused on the pulmonary and cardiovascular systems. Recently, an increase has been observed in the number of studies investigating the relationship between obesity and diabetes and smoking. We investigated the effects of smoking on other serum biochemical parameters and metabolism.
Methods

This is a case-control study. The case and control groups were formed by clinical randomization by using the data obtained from the hospital information system and patient records, including age, gender, height, and weight. Smokers were identified as the case group, while non-smokers were identified as the control group. In the comparisons of rates Chi-square tests were used and in the comparisons of averages, independent sample t and MANCOVA tests were used.
Results

When covariance factors such as age, gender, body mass index, and alcohol use were taken into consideration, It found that AST, ALT, and GGT were higher in smokers, whereas vitamin D, vitamin B12, and TSH were higher in non-smokers.
Conclusions

We found that smoking has a negative effect on liver and bile functions, and vitamin D values ​​are affected secondary to this negative effect.
THE EFFECT OF TAXPAYER INCOME, TAXATION SOCIALIZATION, TAXATION SANCTIONS AND AWARENESS OF TAXPAYER OBJECTIVES TO THE COMPLIANCE OF EARTH AND BUILDING TAXATION IN WONOREJO VILLAGE, PAGERWOJO DISTRICT
Authors: Kristanti Yuni 
Published: February 2022

This study aims to examine the effect of taxpayer income, tax socialization, tax sanctions and awareness of taxpayers on compliance of land and building taxpayers in Wonorejo Village Pagerwojo District Tulungagung Regency partially and simultaneously. This research approach use a quantitative with primary data and secondary data. Data qollection in this study using a questionnaire and documentation . Sampling using a purposive sampling technique with a total sample of 100 respondents. Measurement in this study uses a Likert scale. The data analysis method used is multiple linear regression analysis. The results showed that taxpayer income, tax dissemination and tax sanctions partially had a positive but not significant effect on taxpayer compliance, awareness of taxpayers partially had a significant positive effect on taxpayer compliance. Income taxpayers, taxation socialization, tax sanctions and awareness of taxpayers simultaneously have a significant positive effect on the compliance of land and building taxpayers in Wonorejo Village, Pagerwojo District, Tulungagung Regency.
Assessment of karst water quality and analysis of pollution sources with a projection pursuit algorithm in Jinan spring area, China
Authors: Yu Miao , Xing Xuerui , Xing Liting , Zhao Zhenhua , Li Changsuo 
Published: February 2022

Abstract
Karst water is one of the main drinking water sources in North China. The single factor method and projection pursuit algorithm (PPA) are employed to assess the karst water quality of the Baotu spring area in Jinan. The water quality distribution pattern, its causes, and the main groundwater pollution sources are analyzed. The water quality evaluation results of the PPA model are more reliable than those of the single factor method because the PPA model comprehensively considers the weight and correlation of various factors. The water quality of the study area is generally excellent, but the NO3− index content is high. In recent years, the water quality grades have been mainly class II ∼ class IV. The driving factors of water quality evolution are not only human activities, including artificial recharge, but also natural factors, such as carbonate mineral dissolution. These factors control both the distribution and evolution trend of water quality. Urban nonpoint sources have a significant impact on groundwater quality. Based on the current water quality situation, it is urgent to strengthen protection of the ecological environment in the southern recharge area of the spring region and the water quality control in the western region.
Pharmacological Approach to Atypical Odontalgia Patients: A Systematic Review of Case Reports
Authors: Siregar Yulfani Danisaprina , Putri Farah Asnely , Maulina Tantry 
Published: February 2022

Background:
Atypical odontalgia (AO) is a poorly understood condition of orofacial pain and is often misdiagnosed. The pharmacological approach varies from case to case. This may be due to the differences in etiology, clinical symptoms, as well as comorbidities in each patient.

Objective:
This systematic review aimed at identifying and comprehending the adequate pharmacological approaches in AO management.

Methods:
In this systematic review, case reports that used pharmacological approach(es) as part of the AO management in the last 10 years (2010 to 2020) were reviewed using the PRISMA analysis guidelines. Initial screening was performed using keywords and inclusion criteria in several databases. Subsequently, further screening was carried out by checking for any duplication, followed by an assessment of the title and abstract and the entire content of the case report. All three authors were independently involved in studies selection based on the inclusion criteria, data extraction, and bias assessment.

Results:
Five hundred and ninety-five articles were identified from the initial search. The final result consisted of eleven case reports reviewed in this study. The use of antidepressants in AO management was reported in eight cases, anticonvulsants in five cases, antipsychotic in two cases, opioid analgesics in two cases, and topical analgesics in two cases.

Conclusion:
Based on this systematic review, various pharmacological agents showed adequate results as AO management. Antidepressants seemed to be the most effective ones (PROSPERO registration ID: CRD42021245918).
Blood Pressure Monitoring as a Digital Health Tool for Improving Diabetes Clinical Outcomes: Retrospective Real-world Study
Authors: Fundoiano-Hershcovitz ‪Yifat , Bacher Dror , Ritholz Marilyn D , Horwitz David L , Manejwala Omar , Goldstein Pavel 
Published: February 2022

Background
Remote data capture for blood glucose (BG) or blood pressure (BP) monitoring and the use of a supportive digital app are becoming the model in diabetes and hypertension chronic care. One of the goals in chronic condition management is to increase awareness and generate behavioral change in order to improve outcomes in diabetes and related comorbidities, such as hypertension. In addition, there is a lack of understanding of the association between BG and BP levels when using digital health tools.

Objective
By applying a rigorous study framework to digital health data, this study investigated the relationship between BP monitoring and BG and BP levels, as well as a lagged association between BP and BG. We hypothesized that during the first 6 months of BP monitoring, BG and BP levels would decrease. Finally, we suggested a positive association between BP levels and the following month’s BG levels.

Methods
In this retrospective, real-world case-control study, we extracted the data of 269 people with type 2 diabetes (T2D) who tracked their BG levels using the Dario digital platform for a chronic condition. We analyzed the digital data of the users who, in addition to BG, monitored their BP using the same app (BP-monitoring [BPM] group, n=137) 6 months before and after starting their BP monitoring. Propensity score matching established a control group, no blood pressure monitoring (NBPM, n=132), matched on demographic and baseline clinical measures to the BPM group. A piecewise mixed model was used for analyzing the time trajectories of BG, BP, and their lagged association.

Results
Analysis revealed a significant difference in BG time trajectories associated with BP monitoring in BPM and NBPM groups (t=–2.12, P=.03). The BPM group demonstrated BG reduction improvement in the monthly average BG levels during the first 6 months (t=–3.57, P<.001), while BG did not change for the NBPM group (t=0.39, P=.70). Both groups showed similarly stable BG time trajectories (B=0.98, t=1.16, P=.25) before starting the use of the BP-monitoring system. In addition, the BPM group showed a significant reduction in systolic (t=–6.42, P<.001) and diastolic (t=–4.80, P<.001) BP during the first 6 months of BP monitoring. Finally, BG levels were positively associated with systolic (B=0.24, t=2.77, P=.001) and diastolic (B=0.30, t=2.41, P=.02) BP.

Conclusions
The results of this study shed light on the association between BG and BP levels and on the role of BP self-monitoring in diabetes management. Our findings also underscore the need and provide a basis for a comprehensive approach to understanding the mechanism of BP regulation associated with BG.
Eksistensi Tradisi Mertuq pada Masyarakat Sasak di Desa Wakan Kecamatan Jerowaru Kabupaten Lombok Timur
Authors: Azhari Sukron , Sukardiman  
Published: February 2022

This article examines the mertuq tradition among the Sasak people, who are faced with sophisticated modern medical tools in treating diseases. This study uses a quantitative descriptive model. Data were obtained from in-depth interviews with several key informants selected using purposive techniques. The research was conducted in Wakan Village, Jerowaru District, East Lombok Regency. This study indicates that the existence of the mertuq treatment of the Sasak community cannot be separated from the belief and trust in carrying it out. The people of Wakan Village still maintain mertuq as traditional medicine in overcoming disease even though medical treatment has been so rapid. The people of Wakan Village believe in the magic and efficacy of Mertuq's therapy because it is part of their ancestral heritage.
Abstrak
Artikel ini mengkaji tentang eksistensi tradisi mertuq di kalangan masyarakat sasak, yang berhadapan dengan canggihnya alat pengobatan modern dalam mengobati penyakit. Penelitian ini menggunakan metode kuantitatif model deskriptif. Data diperoleh dari wawancara mendalam kepada beberapa informan kunci yang dipilih menggunakan teknik purposive. Penelitian dilakukan di Desa Wakan, Kecamatan Jerowaru, Kabupaten Lombok Timur. Hasil penelitian ini menunjukkan bahwa eksistensi pengobatan mertuq masyarakat sasak tidak terlepas dari keyakinan dan kepercayaan dalam menjalankannya. Masyarakat Desa Wakan tetap mempertahankan mertuq sebagai pengobatan tradisional dalam mengatasi penyakit walaupun perkembangan pengobatan medis telah begitu pesat. Masyarakat Desa Wakan mempercayai akan kesaktian dan kemanjuran pengobatan mertuq karena bagian dari warisan nenek moyang mereka.
Saúde da mulher e o uso de plantas: um olhar para a saúde única
Authors: Jesus Fernanda , Costa Ana Paula , Marisco Gabriele 
Published: February 2022

O conceito de Saúde Única reconhece que a saúde dos seres humanos, animais e do meio ambiente estão conectadas e devem ser trabalhadas em conjunto. Assim, este trabalho identificou, por meio de um levantamento do conhecimento cultural, as plantas utilizadas para a saúde da mulher a fim de fomentar uma discussão sobre o uso das plantas sob um olhar sustentável e econômico, relacionado com saúde única. Foi aplicado um questionário destinado a mulheres, disponibilizado via mídias sociais. O questionário constituiu-se de 20 perguntas, seguindo os critérios do Comitê de Ética em Pesquisa. Participaram 59 mulheres que utilizam plantas para cólicas menstruais (83,05%, n=45), coceiras vaginais (62,71%, n=37) e/ou menopausa (15,25%, n=9). Para cólica menstrual, as plantas mais citadas foram a camomila, orégano e gengibre; para coceiras e/ou corrimento vaginais, destacaram-se a aroeira e a babosa e para sintomas da menopausa as mais citadas foram amora e a camomila. Portanto, o uso de plantas medicinais no tratamento de enfermidades que acometem a saúde da mulher pode ser uma alternativa terapêutica. Não deixando de ressaltar que as questões relacionadas ao meio ambiente e à saúde humana devem ser estudadas em conjunto, pois os impactos ao meio ambiente, afetam a saúde de todos.
Auditor Expertise in Mergers and Acquisitions
Authors: Gal-Or Ronen , Hoitash Rani , Hoitash Udi 
Published: February 2022

SUMMARY
We contribute to the literature on auditor's task-specific expertise by examining the role of auditor experience in mergers and acquisitions (M&A), a complicated and increasingly prevalent corporate event that can give rise to misreporting. We find that in industries with more complex accounting, clients of M&A expert auditors are less likely to experience M&A-related misstatements. In industries with less complex accounting, M&A experts pass audit fee savings to their clients during acquisition years. Additional analyses suggest that firms are more likely to switch to an M&A expert auditor during an acquisition year, but only in industries with complex accounting. Overall, our results suggest that firms with an acquisitive strategy that engage with M&A expert auditors experience improved M&A-related audit outcomes.
JEL Classifications: M41; M42.