bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yielding capacity and flour-milling properties of spring bread wheat varieties depending on growing environmental conditions
Authors: Vasylenko N. V. , Pravdziva I. V. 
Published: October 2022

Purpose. To determine the dependence of yield and flour-milling properties of new spring bread wheat varie­ties of Myronivka breeding on different growing season conditions.
Methods. During 2017–2019, twelve spring bread wheat varieties were studied in the conditions of the V. M. Remeslo Myronivka Institute of Wheat of NAAS. Grain and flour qua­lity indicators were determined according to conventional methods.
Results. It was found that weather conditions in 2019 were more favorable for realizing the yield potential of spring wheat varieties, but they had a nega­tive impact on quality indicators. By exceeding on 30–40% the standard ‘Elehiia myronivska’, the varieties – ‘Bozhena’ (4.23 t/ha), ‘Oksamyt myronivskyi’ (4.28 t/ha), ‘MIP Svitlana’ (4.31 t/ha), and ‘Dubravka’ (4.62 t/ha) were selected in terms of yield. The varieties ‘Simkoda myronivska’, ‘MIP Zlata’, ‘Bozhena’, ‘MIP Vizerunok’, and ‘MIP Oleksandra’ were singled out by the combination of high physical indicators of grain quality. The varieties ‘Simkoda myronivska’, ‘Oksamyt myronivskyi’, and ‘Panianka’ were distinguished by complex of the highest flour quality indicators. The varieties being the most stable in terms of individual characters were identified. These were ‘Simkoda myronivska’, ‘MIP Zlata’, ‘Bozhena’, ‘Oksamyt myronivskyi’, ‘MIP Svitlana’, and ‘MIP Oleksandra’ by yiel­ding capacity. According to quality indicators, in particular, by 1000 kernel weight, varieties ‘Simkoda myronivska’, ‘MIP Vizerunok’ were distinguished; high scores for grain vitreousness were in most varieties, except for ‘Elehiia myroniv­ska’, ‘Simkoda myronivska’, and ‘MIP Oleksandra’; according to test weight and flour yield, all varieties had high rates; according to the protein content, the variety ‘Oksamyt myronivskyi’ was distinguished; varieties ‘Dubravka’ and ‘MIP Oleksandra’ by wet gluten content. The ANOVA established that the most dependence on weather conditions was revealed for such parameters as 1000 kernel weight (part of influence 83.7%), protein content (76.7%), sedimentation value (66.7%), flour yield (52.6%), gluten deformation index (46.0%), and wet gluten content (42.6%); the most dependence on the interaction of factors year  variety was revealed for yielding capacity (52.3%), the grain vitreousness (50.5%), and the test weight (36.5%). A reliable effect of the factor variety on yield (34.9%) and all investigated quality indicators (5.1–35.1%) was revealed.
Conclusions. It is expedient to use the varieties listed above as sources of certain traits for the creation of new high-yielding and high-quality varieties for different areas of use.
A Rare Case of Enteric Fever with Multiple Splenic Abscesses: Case Report
Authors: Bose Vaishnavi , Thomas Ajith Cherian , Hussein Hazem Elsayed , Junaid Sana , Younas Nadeem Javed 
Published: October 2022

Background:
Enteric fever is a common infection found in many developing countries around the world, which often has life- threatening complications if not treated promptly. One of the rarest complications of enteric fever is splenic abscess.

Case presentation:
Our case is that of a 32-year-old male, admitted with febrile illness, diagnosed as typhoid fever (enteric fever) with rare complication- multiple splenic abscesses, after his travel to endemic area, which was effectively treated with antibiotics under inpatient setting.

Conclusion:
Early diagnosis with imaging modalities such as computed tomography can lead to better treatment approaches. Splenic abscesses are often treated with antibiotics or conservative treatment; however, non-responsive cases may require splenectomy.
Prediction Models based on miRNA-disease Relationship: Diagnostic
Relevance to Multiple Diseases Including COVID-19
Authors: Sharma Anil K. , Sharma Varruchi , Yadav Mukesh , Sehrawat Nirmala , Kumar Vikas , Kumar Sunil , Gupta Ajay , Sharma Pooja , Chakrabarti Sasanka 
Published: October 2022

Background:
Small, non-coding microRNAs, usually of 20-25 nucleotides, are known to
regulate the post-transcriptional gene expression, which has a significant role in human biological
processes, including immune-biogenesis, homeostasis and infection control as differential expression
of such miRNAs is responsible for fine-tuning the organismic development.

Methods:
A search of bibliographic databases was carried out with a focused question on microRNA-
Disease Prediction. A deductive qualitative content analysis approach was employed to
assess the research's overall outcomes, review articles on prediction tools in miRNA-Diseases, and
analyse the interventions.

Results:
Diagnosis and therapeutics of diseases and miRNA prediction methods hold importance in
identifying the regulatory mechanisms. Collections of efficient miRNA prediction methods to identify
miRNA-mRNA-disease regulatory relationships have been presented through this review, consolidating
the potential of miRNAs as a diagnostic and prognostic biomarker of multiple diseases,
including COVID-19.

Conclusions:
The role of miRNA in the aetiology and pathogenesis of wide-range of pathologies,
including viral, bacterial to chronic diseases such as cancer, is quite feasible through the modern
tools in bioinformatics which has been elaborated focusing upon miRNA-disease prediction methods
and their application potential establishing miRNAs as a robust and reliable biomarker in clinicomedical
studies.
Progress in Quantitative Methods for Azelnidipine and Chlorthalidone:
An Analytical Basis for a Recently Approved FDC
Authors: Kotadiya Rajendra , Raimalani Juhi 
Published: October 2022

Backgroound:
Products with multiple active substances mixed in a single dosage form are fixed-dose combinations. These are justified for a variety of reasons. These include a) increasing therapeutic efficacy, b) lowering adverse drug effects, c) pharmacokinetic advantages, d) lowering pill load, e) lowering individual drug doses, and f) lowering drug resistance development.

Objective:
A recently approved fixed dose combination of azelnidipine (8 mg) and chlorthalidone (6.25 or 12.5 mg) is indicated to treat hypertension. Individual quantification methods for azelnidipine and chlorthalidone are available, but no practical and acceptable analytical approach for their combination has been documented. As a result, the goal of this literature review was to gather information on the numerous analytical instrumental approaches utilized to quantify azelnidipine and chlorthalidone in diverse matrices individually. The scientific community could use this information to design a new analytical method for analysing the recently approved combination.

Methods:
Authors have explored various scientific databases to obtain information on analytical methods.

Results:
The methods listed for azelnidipine and chlorthalidone are spectroscopy, high-performance liquid chromatography, hyphenated techniques, high-performance thin-layer chromatography, thin-layer chromatography, and a few other approaches. For azelnidipine and chlorthalidone, there were 26 and 46 research papers reported, respectively.
A Bayesian Network Analysis of the Efficacy of Scaffolds and Stem Cells in
Spinal Cord Injury Treatment
Authors: Wang Yang , Yi Hanxiao 
Published: October 2022

Backgrond:
Novel scaffolds and stem cells are alternatives for the treatment of spinal cord
injury (SCI), which causes life-long disability. However, there is a lack of synthesized evidence comparing
different therapies.

Aim:
To examine the efficacy of various treatments in achieving locomotor recovery in SCI animals. The
PubMed, Scopus and Web of Science databases were searched from inception to 21st May 2021.

Methods:
The data were extracted by one investigator under the surveillance of a referee according to the
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement and
stored in Microsoft Excel. All data were analysed using Bayesian network analysis with a consistency
model. The selection was performed in strict accordance with the participant, intervention, comparison,
outcome and study (PICOS) principle, as specifically stated in the methods section.

Results:
A total of 387 eligible studies involving 11169 animals subjected to 5 different treatments were
evaluated. Compared to placebo or no treatment, scaffolds (mean difference (MD), 2.04; 95% credible
interval (CrI): 1.58 to 2.50), exosomes (MD, 3.46; 95% CrI: 3.07 to 3.86), stem cells (MD, 4.18; 95% CrI:
3.28 to 5.07), scaffolds in conjunction with stem cells (MD, 5.26; 95% CrI: 4.62 to 5.89), and scaffolds in
conjunction with non-cell agents (MD, 4.88; 95% CrI: 4.21 to 5.54) led to significant recovery of locomotor
function in SCI animals. No significant difference in the locomotor function score was observed between
animals treated with stem cells and those treated with exosomes (MD, 0.71; 95% CrI: -0.25 to
3.05), between animals treated with scaffolds in conjunction with stem cells and those treated with scaffolds
in conjunction with non-cell agents (MD, -0.38; 95% CrI: -1.24 to 0.49), or between animals treated
with scaffolds in conjunction with non-cell agents and those treated with stem cells (MD, 0.71; 95% CrI: -
0.38 to 1.80).

Conclusion:
Significant differences in the efficacy of various therapies in SCI animals were observed,
and transplantation of scaffolds in conjunction with non-cell agents, scaffolds in conjunction with stem
cells, and stem cells should be considered over transplantation of exosomes or scaffolds alone. Even
though transplantation of scaffolds alone promoted locomotor function recovery in SCI animals, its use
should be discouraged.
Research on MapReduce Heuristic Multi Table Join Algorithm Based on
Binary Optimization and Pancake Parallel Strategy
Authors: Jia Songhao , Yang Jizheng , Yang Cai , Zhang Haiyu 
Published: October 2022

Background:
With the development of technology, the data amount has increased significantly.
In data processing, the multi table query is the most frequent operation. Because the join
keys cannot correspond one by one, there will be much redundant data transmission, resulting in a
waste of network bandwidth.

Objective:
In order to solve the problems of network overhead and low efficiency, this paper proposes
a heuristic multi table join optimization method. By sharing information, the unconnected tuples
are eliminated so as to reduce the amount of data transmitting. This shortens response time and
improves execution performance.

Method:
Firstly, the join key information of one table is compressed by the algorithm to make the
filtered information for sharing. Then, the concurrent execution is controlled according to the pancake
parallel strategy. Finally, the selection strategy of multi table join order is proposed.

Results/Discussion:
The experiments show that the proposed algorithm can filter a large amount of
useless data and improve query efficiency. At the same time, the proposed algorithm reduces a lot of
network overhead, improves the algorithm performance, and better solves the problem of low efficiency
of multi table join.

Conclusion:
This paper introduces the heuristic strategy to optimize the algorithm, so that it can
perform the join tasks in parallel, which further improves the performance of multi table join. The
algorithm creatively combines heuristic data filtering, which greatly improves the quality of data
processing. The algorithm is worth popularizing and applying.
Developing an mHealth Intervention to Reduce COVID-19–Associated Psychological Distress Among Health Care Workers in Nigeria: Protocol for a Design and Feasibility Study
Authors: Akinsulore Adesanmi , Aloba Olutayo , Oginni Olakunle , Oloniniyi Ibidunni , Ibigbami Olanrewaju , Seun-Fadipe Champion Tobi , Opakunle Tolulope , Owojuyigbe Afolabi Muyiwa , Olibamoyo Olushola , Mapayi Boladale , Okorie Victor Ogbonnaya , Adewuya Abiodun Olugbenga 
Published: October 2022

Background
Globally, COVID-19–related psychological distress is seriously eroding health care workers’ mental health and well-being, especially in low-income countries like Nigeria. The use of mobile health (mHealth) interventions is now increasingly recognized as an innovative approach that may improve mental health and well-being. This project aims to develop an mHealth psychological intervention (mPsyI) to reduce COVID-19–related psychological distress among health care workers in Nigeria.

Objective
Our objective is to present a study protocol to determine the level of COVID-19–related psychological distress among health care workers in Nigeria; explore health care workers’ experience of COVID-19–related psychological distress; develop and pilot test mPsyI to reduce this distress; and assess the feasibility of this intervention (such as usability, engagement, and satisfaction).

Methods
A mixed (quantitative and qualitative) methods approach is used in which health care workers will be recruited from 2 tertiary health care facilities in southwest Nigeria. The study is divided into 4 phases based on the study objectives. Phase 1 involves a quantitative survey to assess the type and levels of psychosocial distress. Phase 2 collects qualitative data on psychosocial distress among health care workers. Phase 3 involves development of the mHealth-based psychological intervention, and phase 4 is a mixed methods study to assess the feasibility and acceptability of the intervention.

Results
This study was funded in November 2020 by the Global Effort on COVID-19 Health Research, and collection of preliminary baseline data started in July 2021.

Conclusions
This is the first study to report the development of an mHealth-based intervention to reduce COVID-19–related psychological distress among health care workers in Nigeria. Using a mixed methods design in this study can potentially facilitate the adaptation of an evidence-based treatment method that is culturally sensitive and cost-effective for the management of COVID-19–related psychological distress among health care workers in Nigeria.

International Registered Report Identifier (IRRID)
DERR1-10.2196/36174
Use of Telemedicine in Pediatric Services for 4 Representative Clinical Conditions: Scoping Review
Authors: Southgate Genevieve , Yassaee Arrash A , Harmer Matthew J , Livesey Helen , Pryde Kate , Roland Damian 
Published: October 2022

Background
Telemedicine is becoming routine in health care. Postpandemic, a universal return to face-to-face consultations may risk a loss of some of the advantages of telemedicine. However, rapid implementation and adoption without robust evaluation of usability, efficacy, and effectiveness could potentially lead to suboptimal health outcomes and downstream challenges to providers.

Objective
This review assesses telemedicine interventions against international guidance and sufficiency of evidence to support postpandemic utilization in pediatric settings.

Methods
This scoping review was performed following searches on PubMed, Embase, and CINAHL databases on April 15, 2021, and May 31, 2022, and examined studies focused on telemedicine, remote consultation, video call, or remote patient monitoring in children (0-18 years) receiving outpatient care for diabetes, asthma, epilepsy, or renal disease. Exclusion criteria included studies published before 2011 as the technologies used have likely been improved or replaced, studies in adult populations or where it was not possible to disaggregate data for participants younger than 18 years as the focus of the review was on pediatric care, and studies not published in English. Data were extracted by 4 authors, and the data were corroborated by a second reviewer. Studies were examined for feasibility and usability, clinical and process outcomes, and cost-effectiveness.

Results
Of the 3158 studies identified, 56 were suitable for final inclusion and analysis. Data on feasibility or usability of interventions (48 studies) were overwhelmingly positive in support of telemedicine interventions, with common themes including convenience, perceived cost savings, and ease of use. However, use in preference to usual care was rarely explored. Clinical and process outcome data (31 studies) were mostly positive. Across all studies, there was limited measurement of standardized clinical outcomes, although these were more commonly reported in asthma (peak flow) and diabetes (glycated hemoglobin [HbA1c]). Implementation science data generally supported cost-effectiveness of telemedicine with a reduction of health care costs.

Conclusions
There is promising evidence supporting telemedicine in pediatric settings. However, there is a lack of evaluation of telemedicine in comparison with usual outpatient care for noninferiority of clinical outcomes, and this review highlights the need for a more standardized approach to evaluation of digital interventions.
Developing and Integrating Asynchronous Web-Based Cases for Discussing and Learning Clinical Reasoning: Repeated Cross-sectional Study
Authors: Tat Sonny , Shaukat Haroon , Zaveri Pavan , Kou Maybelle , Jarvis Lenore 
Published: October 2022

Background
Trainees rely on clinical experience to learn clinical reasoning in pediatric emergency medicine (PEM). Outside of clinical experience, graduate medical education provides a handful of explicit activities focused on developing skills in clinical reasoning.

Objective
In this paper, we describe the development, use, and changing perceptions of a web-based asynchronous tool to facilitate clinical reasoning discussion for PEM providers.

Methods
We created a case-based web-based discussion tool for PEM clinicians and fellows to post and discuss cases. We examined website analytics for site use and collected user survey data over a 3-year period to assess the use and acceptability of the tool.

Results
The learning tool had more than 30,000 site visits and 172 case comments for the 55 published cases over 3 years. Self-reported engagement with the learning tool varied inversely with clinical experience in PEM. The tool was relevant to clinical practice and useful for learning PEM for most respondents. The most experienced clinicians were more likely than fellows to report posting commentary, although absolute rate of commentary was low.

Conclusions
An asynchronous method of case presentation and web-based commentary may present an acceptable way to supplement clinical experience and traditional education methods for sharing clinical reasoning.
Evaluating Health Care Provider Perspectives on the Use of Mobile Apps to Support Patients With Heart Failure Management: Qualitative Descriptive Study
Authors: Sivakumar Bridve , Lemonde Manon , Stein Matthew , Goldstein Sarah , Mak Susanna , Arcand JoAnne 
Published: October 2022

Background
Nonadherence to diet and medical therapies in heart failure (HF) contributes to poor HF outcomes. Mobile apps may be a promising way to improve adherence because they increase knowledge and behavior change via education and monitoring. Well-designed apps with input from health care providers (HCPs) can lead to successful adoption of such apps in practice. However, little is known about HCPs’ perspectives on the use of mobile apps to support HF management.

Objective
The aim of this study is to determine HCPs’ perspectives (needs, motivations, and challenges) on the use of mobile apps to support patients with HF management.

Methods
A qualitative descriptive study using one-on-one semistructured interviews, informed by the diffusion of innovation theory, was conducted among HF HCPs, including cardiologists, nurses, and nurse practitioners. Transcripts were independently coded by 2 researchers and analyzed using content analysis.

Results
The 21 HCPs (cardiologists: n=8, 38%; nurses: n=6, 29%; and nurse practitioners: n=7, 33%) identified challenges and opportunities for app adoption across 5 themes: participant-perceived factors that affect app adoption—these include patient age, technology savviness, technology access, and ease of use; improved delivery of care—apps can support remote care; collect, share, and assess health information; identify adverse events; prevent hospitalizations; and limit clinic visits; facilitating patient engagement in care—apps can provide feedback and reinforcement, facilitate connection and communication between patients and their HCPs, support monitoring, and track self-care; providing patient support through education—apps can provide HF-related information (ie, diet and medications); and participant views on app features for their patients—HCPs felt that useful apps would have reminders and alarms and participative elements (gamification, food scanner, and quizzes).

Conclusions
HCPs had positive views on the use of mobile apps to support patients with HF management. These findings can inform effective development and implementation strategies of HF management apps in clinical practice.
Tối ưu hóa quy trình ly trích cao chiết lá xạ đen (Celastrus hindsii) giàu polyphenol, flavonoid có hoạt tính kháng oxy hóa và kháng đái tháo đường in vitro
Authors: Đái Thị Xuân Trang , Nguyễn Thúy Tố Minh , Nguyễn Hoàng Duy , Trần Chí Linh , Phan Ngọc Thùy Ngân 
Published: October 2022

Khảo sát được bố trí theo phương pháp đáp ứng bề mặt dựa vào mô hình Box-Behnken trong phần mềm Design Expert 11.0 để tối ưu các điều kiện ly trích polyphenol và flavonoid trong lá xạ đen (LXĐ). Nghiên cứu đã ly trích được polyphenol (120,30±1,15 mg GAE/g cao chiết), flavonoid (302,39±1,78 mg QE/g cao chiết) tối ưu bằng phương pháp ngâm trong ethanol 69% (v/v) 6 giờ, tỷ lệ nguyên liệu/dung môi là 1/36 (w/v) và nhiệt độ ly trích 60°C. Cao tối ưu LXĐ giàu polyphenol và flavonoid đã được nghiên cứu hoạt động kháng oxy hóa và kháng đái tháo đường in vitro. Kết quả cho thấy, cao tối ưu LXĐ thể hiện các hoạt động trung hòa và khử hiệu quả các gốc tự do trong thử nghiệm DPPH (EC50=26,73±1,16 µg/mL), NO• (EC50=55,43±0,78 µg/mL), ABTS•+ (EC50=7,79±0,01 µg/mL), RP (EC50=9,03±0,12 µg/mL) và FRAP (EC50=9,20±0,30 µg/mL) và TAC (EC50=59,49±2,61 µg/mL). Cao tối ưu LXĐ cũng ức chế đáng kể hoạt động của enzyme α-amylase và α-glucosidase với các giá trị EC50 lần lượt là 156,03±0,43 μg/mL, 26,33±0,76 μg/mL. Nghiên cứu này cho thấy cao tối ưu LXĐ giàu polyphenol và flavonoid là một tác nhân kháng oxy hóa...