bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the incidence of complications and malignancies in the long-term management of benign biliary strictures with a percutaneous transhepatic drain
Authors: Yoshitomi Munehiro , Kawahara Ryuichi , Taniwaki Shinichi , Midorikawa Ryuta , Kojima Satoki , Muroya Daisuke , Arai Shoichiro , Shirahama Takahisa , Kanno Hiroki , Fukutomi Shogo , Goto Yuichi , Nomura Yoriko , Akashi Masanori , Sato Toshihiro , Sakai Hisamune , Hisaka Toru , Akagi Yoshito 
Published: April 2022

Abstract
Percutaneous drainage catheters (PDCs) are required for the management of benign biliary strictures refractory to first-line endoscopic treatment. While biliary patency after PDC placement exceeds 75%, long-term catheterization is occasionally necessary. In this article, we assess the outcomes of patients at our institution who required long-term PDC placement.
A single-institution retrospective analysis was performed on patients who required a PDC for 10 years or longer for the management of a benign biliary stricture. The primary outcome was uncomplicated drain management without infection or complication. Drain replacement was performed every 4 to 12 weeks as an outpatient procedure.
Nine patients (three males and six females; age range of 48–96 years) required a long-term PDC; eight patients required the long-term PDC for an anastomotic stricture and one for iatrogenic bile duct stenosis. A long-term PDC was required for residual stenosis or patient refusal. Drain placement ranged from 157 to 408 months. In seven patients, intrahepatic stones developed, while in one patient each, intrahepatic cholangiocarcinoma or hepatocellular carcinoma occurred.
Long-term PDC has a high rate of complications; therefore, to avoid the need for using long-term placement, careful observation or early surgical interventions are required.
The Detection Performance of 18F–Prostate-Specific Membrane Antigen-1007 PET/CT in Primary Prostate Cancer
Authors: Huang Ya-Ting , Tseng Neng-Chuan , Chen Yen-Kung , Huang Kuo-How , Lin Hsiu-Ying , Huang Ya-Yao , Hwang Thomas I. S. , Ou Yen-Chuan 
Published: April 2022

Background
Multiple tools are now available to determine the requirement for a biopsy to diagnose prostate cancer, and PET/CT with radiolabeled prostate-specific membrane antigen (PSMA)–targeting radiotracers has been recommended for detecting primary prostate cancer. Particularly, the radiotracer 18F-PSMA-1007 was found to be more favorable for primary tumors compared with other PSMA-targeting radiotracers because of its low clearance via the urinary tract and better image resolution. Thus, we performed a systematic review and meta-analysis to more accurately evaluate the detection performance of 18F-PSMA-1007 PET/CT in primary prostate cancer patients.

Methods
An update on the databases of PubMed/MEDLINE, EMBASE, and Cochrane Library for comprehensive literature search was performed on September 30, 2021. The pooling detection rate was calculated on a per-patient basis. The pooling median of the SUVmax was analyzed from the included studies. Furthermore, the positive predictive value of 18F-PSMA-1007 PET/CT with pathologic lesions was analyzed using the criterion standard.

Results
Twelve studies (540 patients total) were included in the meta-analysis. The overall pooling detection rate of 18F-PSMA-1007 per patient was 94%, and the pooling median of SUVmax located at the intraprostate tumor was 16 (range, 3.7–77.7). The positive predictive value of 18F-PSMA-1007 per lesion with histopathological validation was 0.90, detecting regional lymph node metastasis was 0.94, and detecting localized prostatic tumors was 0.84.

Conclusions
In the current meta-analysis, we revealed the excellent performance of 18F-PSMA-1007 to detect localized prostatic tumor lesions and regional lymph node metastasis. Moreover, the uptake of localized tumors in primary prostate cancer was nearly liver uptake and may be considered a suspicious malignancy if it was equal to or greater than the liver uptake.
Usefulness of 68Ga-Pentixafor PET/CT on Diagnosis and Management of Cushing Syndrome
Authors: Ding Jie , Tong Anli , Hacker Marcus , Feng Ming , Huo Li , Li Xiang 
Published: April 2022

PurposeThis pilot study investigated the performance of C-X-C motif chemokine receptor 4 (CXCR4) molecular imaging (68Ga-pentixafor PET/CT) in Cushing syndrome (CS) and the correlation between CXCR4 signaling interactions and glucose metabolism in adrenocorticotropin-cortisol pathway.MethodsWe retrospectively evaluated 31 patients (16 patients with CS and 15 patients with nonfunctioning pituitary or adrenal adenomas). All patients underwent68Ga-pentixafor PET/CT, and 11 with pituitary adenoma also underwent18F-FDG PET/CT. The diagnosis accuracy of68Ga-pentixafor PET/CT was calculated. The correlation between radiouptake along the pituitary-adrenal axis and hormone levels was calculated.ResultsPatients with Cushing disease characterized a focal uptake in adrenocorticotropic hormone–producing pituitary adenoma (ACTH-PA). In ACTH-independent CS, there was increased uptake of68Ga-pentixafor in adrenal lesions but not in the pituitary fossa. The nonfunctioning pituitary or adrenal adenomas showed negative68Ga-pentixafor signal. The one patient with metastatic ectopic ACTH syndrome had multiple68Ga-pentixafor–avid lesions. Using the threshold of SUVmax>8.5 in the adrenal lesions, the sensitivity and specificity of68Ga-pentixafor PET/CT to diagnose cortisol-producing adenoma were 100% and 84.9%. A cutoff SUVmaxvalue of 3.0 on68Ga-pentixafor PET/CT had 100% sensitivity and specificity for differentiating ACTH-PA. The corresponding hormone level was significantly correlated with uptake of68Ga-pentixafor in pituitary adenoma and adrenal tissue but not with glucose metabolism.ConclusionWe have characterized the performance of68Ga-pentixafor in different subtypes of CS.68Ga-pentixafor PET/CT is promising in the differential diagnosis of both ACTH-independent and ACTH-dependent CS. Activated CXCR4 molecular signaling along the pituitary-adrenal axis was found in patients with Cushing disease.
Clinical and haematological profile of dengue among adult patients at a tertiary care hospital in Pokhara
Authors: Dhungana Durga , Banstola Bidhya , Banjara Mahesh 
Published: April 2022

AbstractIntroductionDengue is an important infectious disease. This disease is prevalent in the terai belts of Nepal mainly. But in the last few years, the cases are in increasing trend in the hilly areas of Nepal also. Hence this study was done in an aim to study the clinical and haematological profile of the dengue cases.MethodsThis was a retrospective cross-sectional quantitative study done at a tertiary teaching hospital of Pokhara, Nepal after obtaining ethical approval from the institutional ethical committee. The data of serologically confirmed dengue cases, during the period of August 2019 to December 2019, of age above 15 years, were collected and analysed using SPSS 20. Descriptive analysis in terms of mean, median, percentage as well as t-test for nominal and chi-square tests were used to compare different parameters. P-value≤ 0.05 was considered statistically significant.ResultsOut of 922 patients, approximately one-half (50.5%) cases were seen during the month of September. Most (82.8%) were the inhabitants of Kaski district. Median age of presentation was 29 years with slightly more cases of males (52.4%). Three hundred and forty seven patients were admitted. Fever (96.5%) and headache (40.6%) were the most common symptoms on presentation of admitted cases. Leukopenia (55.3%) was more common than thrombocytopenia (47.6%) in the admitted cases. On comparison between admitted patients with warning signs and those without signs, no significant variation was seen in terms of age, total leukocyte count and total platelet count.ConclusionDengue is common in young population. Fever, headache and gastrointestinal symptoms are common among dengue patients. Leukopenia and thrombocytopenia are common laboratory features of dengue.
Polio Virotherapy of Malignant Glioma Engages the Tumor Myeloid Infiltrate and Induces Diffuse Microglia Activation
Authors: Yang Yuanfan , Brown Michael C. , Zhang Gao , Stevenson Kevin , Mohme Malte , Kornahrens Reb , Bigner Darell D. , Ashley David M. , López Giselle Y. , Gromeier Matthias 
Published: April 2022

AbstractMalignant gliomas commandeer an abundant inflammatory infiltrate with glioma-associated macrophages and microglia (GAMM) actively promoting tumor progression. Like all cells in the mononuclear phagocytic system, macrophages and microglia constitutively express the poliovirus receptor, CD155. Besides myeloid cells, CD155 is widely upregulated ectopically in the neoplastic compartment of malignant gliomas (and solid cancers in general). Intratumor treatment with the highly attenuated rhino:poliovirus chimera, PVSRIPO, yielded long-term survival with durable radiographic responses in patients with recurrent glioblastoma (Desjardins et al. New England Journal of Medicine, 2018). Here, we studied mechanisms of PVSRIPO immunotherapy in mouse brain tumor models to decipher contributions of myeloid vs. malignant cells to antitumor efficacy. PVSRIPO treatment caused intense engagement of the GAMM infiltrate associated with substantial, but transient tumor regression. This was accompanied by diffuse microglia activation and proliferation in the normal central nervous system (CNS) surrounding the tumor, extending to the ipsilateral and even the contralateral hemispheres. PVSRIPO-instigated microglia activation occurred against a backdrop of sustained innate antiviral inflammation, associated with induction of the PD-L1 immune checkpoint on GAMM. Combining PVSRIPO with PD1/PD-L1 blockade led to durable remissions. Our work implicates GAMM as active drivers of PVSRIPO-induced antitumor inflammation and reveals profound and widespread neuroinflammatory activation of the CNS-resident myeloid compartment by PVSRIPO.
The structure and evolutionary diversity of the fungal E3-binding protein
Authors: Forsberg Bjoern O. 
Published: April 2022

AbstractThe pyruvate dehydrogenase complex (PDC) is a central metabolic enzyme in all living cells composed majorly of E1, E2, and E3. Tight coupling of their reactions makes each component essential, so that loss impacts oxidative metabolism pathologically. E3 retention is mediated by the E3-binding protein (E3BP), which has not previously been clearly resolved within the PDC. Here, the structure of the fungal E3BP in complex with the PDC core from N.crassa is resolved to 3.2Å, showing its mode of binding. Fungal and mammalian E3BP are shown to be orthologs, arguing E3BP as a broadly eukaryotic gene. Fungal E3BP architectures predicted from sequence data and computational models further bridge the evolutionary distance between N. crassa and humans, and suggest discriminants for E3-specificity. This is confirmed by similarities in their respective E3-binding domains, where a novel interaction is also predicted that may affect the interaction of its lipoyl substrate with recruited E3.
The decline in agricultural share and agricultural industrialization—some stylized facts and theoretical explanations
Authors: Liu Shouying , Wang Baojin 
Published: April 2022

PurposeThe decline in the share of agriculture in both output and employment is a central feature of structural transformation. The authors present the distinct features between developed and developing countries in the process of agricultural share decline and dig into the real changes that occurred in the agricultural sector during the rapid decline in the agricultural share.Design/methodology/approachTaking the declining share of agriculture as a clue, the authors depict heterogeneous characteristics in the declining share of agriculture in developed and developing countries. Secondly, by criticizing the factor substitution hypothesis, the authors argue that the essence of agricultural transformation is the process of agricultural industrialization characterized by the combination, reconstruction, and continual changes of agricultural production factors. Finally, based on the theory of agricultural industrialization, this paper analyzes the combination of factors in different stages of declining agricultural share in typical economies.FindingsIn this paper, the authors find that the rapid decline in agricultural employment share is accompanied by an increase in the returns to agricultural production in developed economies. In contrast, the decline in agricultural employment share in developing economies lags, and agricultural production efficiency is way much poorer than that of developed economies. Taking the United States and Japan as examples, the authors find that the agricultural sector underwent agricultural industrialization, featured by reconstruction and upgrades of production factors combination.Originality/valueThe authors systematically reveal why huge changes occurred in the agricultural sector in developed economies during structural transformation, and also provide further thoughts and lessons for developing countries to accomplish agricultural modernization.
Rally-around-the-organizational-flag? Internal communication in a professional organization during the Covid-19 pandemic crisis
Authors: Falkheimer Jesper , Heide Mats , Simonsson Charlotte , Andersson Rickard 
Published: April 2022

PurposeThis study aims, first, to explore and analyze if and how organizational members’ professions or occupations influence perceptions of internal crisis communication. The second, related, aim is to discuss the role of internal communication in creating a strong organizational identity during a prolonged crisis such as the Covid-19 pandemic.Design/methodology/approachThis study is mainly conceptual but uses quantitative data from a survey conducted in a health-care organization in late 2020 to illustrate the theoretical reasoning.FindingsThe results show that the administrative groups perceive factors in the internal crisis communication more favorably than the professional groups. The study suggests that organizational members perceive internal crisis communication differently depending on which intra-organizational group they belong to. This further points to the absence of a “rally-around-the-flag” effect and highlights the importance of working proactively with professionals and in internal crisis communication.Originality/valueThis study highlights the role of professionals in crisis communication, which is an aspect that so far has been ignored. The internal professionalization processes and an intriguing power struggle between professions have obvious consequences for crisis communication. As shown in the overview of earlier research on internal communication, leadership and professional organizations, the prerequisites for creating an increased organizational unity among coworkers are challenging. The idea that a crisis may, as in certain political situations in society, create a “rally-around-the-flag” effect is still relevant, even if the case study is an example of how this did not happen.
Intellectual capital and the acquisition of human capital by technology-based new ventures
Authors: Zane Lee J. 
Published: April 2022

PurposeIntellectual Capital (IC) is essential to the success of new technology-based firms. A key component of IC is human capital. Human capital is shown to affect firm innovation, growth, and survival positively. This paper investigates the signaling effect of technology-based start-ups’ initial stock of IC on obtaining skilled human capital.Design/methodology/approachThe researcher employs signaling theory to analyze primary data concerning the firm’s initial stock of IC and subsequently hired human capital from founders of 236 technology-based new ventures in the USA Hypotheses are tested through a set of hierarchical linear regressions.FindingsThis study demonstrates that the firms’ IC, in the form of quantity of founders with doctorates and intellectual property, correlates with the quality (average education level) of subsequently hired technical and business human capital. In addition, the quantity of founders with doctorates is correlated with the quantity of subsequently hired technical human capital.Originality/valueThe paper collects retrospective data from founders of technology-based new ventures. While human capital is important for technology-based firms’ innovation and growth, little research has investigated potential connections between firms’ initial IC and subsequent hiring of top-level human capital. This paper investigates these connections explicitly.
Trait affectivity and applicant reactions: a multiwave field study
Authors: Harari Michael B. , Kraus Eyran , Boyi Victor , Viswesvaran Chockalingam , Haas Craig 
Published: April 2022

PurposeAlthough affective accounts of organizational justice theory have been offered, suggesting a role played by trait affectivity dimensions – trait positive affectivity (TPA) and trait negative affectivity (TNA) - in shaping applicant reactions to selection procedures, research in this area relies on cognitive information processing accounts of justice perceptions. Thus, the role played by TPA and TNA in shaping applicant reactions is an underexplored area. This study explicates and tests the role of TPA and TNA in shaping reactions.Design/methodology/approachThe authors carried out a three-wave field study of police job applicants, measuring TPA and TNA before testing and applicant justice perceptions and recommendation intentions pre-feedback and post-feedback.FindingsTPA, but not TNA, was positively associated with justice perceptions and recommendation intentions. Mediation analyses suggested that the TPA-recommendation intentions relationship was mediated through justice perceptions.Practical implicationsRecruiting high TPA applicants can benefit future applicant pools due to enhanced recommendation intentions. High TPA applicants react more favorably to positive features; thus, procedures should conform to procedural justice rules so that favorable aspects exist for high TPA applicants to respond favorably towards.Originality/valueThe authors’ work is the first to integrate affective accounts of the justice perception formation process into applicant reactions research. Their work supports a role served by affect in shaping applicant fairness perceptions and provides novel and important insights for both theory and practice.
Libraries and financial literacy
Authors: Kiszl Péter , Winkler Bea 
Published: April 2022

PurposeThe recent financial crises and the economic problems caused by the pandemic highlight the importance of financial literacy (FL). Libraries have an essential role in developing informational literacy and promoting access to information. In this study the authors seek to identify, based on the published literature, in which areas and in what roles libraries engage in the development of FL, and what options are available for those who intend to set out in this direction in the near future.Design/methodology/approachThe basis of the research is a review of the literature, as comprehensive as possible, achieved by keyword- and discipline-focused searches run in the Library, Information Science and Technology Abstracts (LISTA), the Web of Science (WoS) and the Scopus database. At the beginning of the study, the initial list of results had 765 publications, but this number decreased significantly after removing duplicates and sorting the results. Finally, 138 publications were included in the analysis.FindingsLibraries engage in the development of FL mostly through their collections, with recommendations, through education, by organizing programs and through information service. Most successful methods do not require any specialized FL knowledge from librarians. Necessary competences are more related to organizational skills, cooperation with partners and creativity.Research limitations/implicationsThe study is based on publications which include the term financial culture, any of its synonyms, or broader or more specific terms and which are related to libraries in the manner described in the search strategy. The international literature databases chosen for the searches limited the scope of the articles available for inclusion.Originality/valueThe study summarizes the results in libraries related to FL from the past 10 years. There has been no other similar summary published recently applicable in practice.
The Politics of Covid Vaccine Hesitancy and Opposition
Authors: Sorell Tom , Butler Jethro 
Published: April 2022

AbstractOpposition to vaccines is not a new phenomenon, but positions once associated with traditional religious or conservative stances have given way to some highly disparate views that transcend traditional left/right/religious divisions. This article reviews recent literature showing how social media has contributed to the spread of conspiracy theories around Covid‐19 and mass vaccination programmes. The narratives discussed are principally those of the right and the religious right.
Cross‐mapping medical records to NANDA‐I to identify nursing diagnoses in a vulnerable population
Authors: Fernández‐Gutiérrez Domingo Ángel , Brito‐Brito Pedro Ruymán , Darias‐Curvo Sara , Cabrera‐de‐León Antonio , Martínez‐Alberto Carlos Enrique , Aguirre‐Jaime Armando 
Published: April 2022

ABSTRACTPurposeTo assess the association between vulnerable populations and nursing care needs, using NANDA‐I diagnostics, in the population of the Canary Islands, Spain.MethodsNursing social epidemiology study. Cross Mapping of Medical Records to NANDA‐I to Identify Nursing Diagnoses in a Population usinga medical, epidemiological follow‐up study of a cohort of 7,190 people. The level of vulnerability of the participants was assigned, among those who were also assigned nursing diagnoses, using the “ICE index” to calculate the expected associations.FindingsThe most prevalent nursing diagnosis in our sample was Sedentary lifestyle (60.5%), followed by Ineffective health self‐management (33.8%) and Risk‐prone health behaviour (28.7%). Significant differences were found by sex, age group and social class, with the nursing diagnoses included in the study being more prevalent among the most socio‐economically disadvantaged social class.Conclusions: The cross‐mapping method is useful to generate diagnostic information in terms of care needs, using the NANDA‐I classification. The expected associations between high social vulnerability and care needs have been verified in a comprehensive and representative sample of the Canarian population (Spain).Implications for nursing practiceFrom an epidemiological perspective, identifying nursing diagnoses at the population level allows us to find the most prevalent needs in the different community groups and to focus appropriate nursing interventions for their implementation and impact assessment.