bluuebunny/crossref_metadata_2025_split huggingface dataset:
MORPHOLOGICAL AND FUNCTIONAL FEATURES OF OSTEOREGENERATION FOUR MONTHS AFTER IMPLANTATION OF "BAK-1000" IN COMBINATION WITH ANGIOSTIMULATED MSCs
Authors: Demyashkin Grigory , Ivanov Sergey , Orlov Andrey , Saburina Irina , Nuruev Gasi , Fidarov Aslanbek , Vadyukhin Matvey , Bondarenko Fedor 
Published: November 2022

Annotation
Approbation of osteoplastic materials with the study of the mechanisms and development of methods of osteoregeneration remains one of the topical areas of research in surgical and orthopedic dentistry, requiring an integrated approach at various levels of organization of living systems.
The aim of the study was to evaluate osteoregeneration in a model of bone diastasis using "BAK-1000" in combination with VEGF-stimulated MSCs.
Materials and methods. Male Sprague-Dawley rats (n = 45) were divided into two groups: I – control (n = 15) and experimental – II (n = 15) and III (n = 15). The creation of the osseointegration model included two surgical stages: at the first stage, MSCs were cultured; on the second stage, osteotomy was performed (groups I–III), the resulting defects were filled with implant material (groups II, III) in combination with autologous MSCs (only group III).
Results. On the 120th day after completion of the second stage of the operation in group II, a low intensity of angiogenesis and osteogenesis was observed with partial local destruction of the cellular canalicular matrix. Group III showed moderate osteoregeneration and intense angiogenesis. However, in both groups, the formation of yellow microcrystals caused the development of signs of necrobiosis.
Discussion. On the basis of the study, it was found that in groups II and III in the peri-implantation tissue, there was indeed a sharp hyperplasia of blood vessels, which was combined in time with the initial signs of osteogenesis. The identified negative changes in the peri-implant area were probably associated with the biological properties of the implanted material.
Conclusions. There were no signs of pronounced osteoregeneration, and the proposed method for eliminating a bone defect using BAK-1000 in combination with VEGF-stimulated MSCs can be considered ineffective.
CERAMIC IMPLANTS ARE THE FUTURE OF DENTAL IMPLANTOLOGY
Authors: Dovgerd Aleksandr , Sivolapov Konstantin 
Published: November 2022

The subject of the study is the main properties of ceramic dental implants.
Objectives. A systematic analysis of modern domestic and foreign literary sources to determine the main advantages of ceramic dental implants.
Methodology. The study was based on the search and study of original articles on the dental implantology in the databases: Russian State Library, eLibrary, PubMed, The Cochrane Library, Google Scholar. The main selection of materials was carried out by keywords.
Results. Currently, dental ceramic implants are attracting more and more attention from both dentists and patients. Every year, the clinical use of ceramic implants is becoming wider. Only in Europe every year there are 3 major congresses on ceramic implantology. In many countries, the number of associations dealing with this particular topic has increased, ceramic implants have unlimited potential for clinical use.
Numerous studies show that the clinical use of zirconium oxide implants is practically not accompanied by manifestations of peri-implantitis, and gum epithelial tissues are able to firmly and reliably attach to their surface. Zirconium forms a dense ZrO2 dioxide film on the surface with good protective properties. Zirconia is bioinert to other materials found in the oral cavity and is particularly suitable for patients who are allergic or intolerant to metals. The latest materials and techniques, which include zirconium dioxide, have important advantages, and its use as dental implants significantly increases the clinical effectiveness of treatment. Therefore, when planning dental implantation, preference should be given to zirconia implants, which will avoid the development of a negative effect of treatment on both organs and tissues of the oral cavity, and the body as a whole.
Conclusions. The review of literature sources on the effectiveness of ceramic dental implants showed evidence-based possibilities for the clinical use of this type of implants in modern dentistry.
METHODS OF DIAGNOSIS AND TREATMENT OF ORAL MUCOSAL LEUKOPLAKIA (LITERATURE REVIEW)
Authors: Lunitsyna Yuliya , Ziablitskaia Kseniia , Bondarenko Olga , Chudova Larisa , Shteinke Ella 
Published: November 2022

Subject. The high prevalence of oral mucosal leukoplakia, its often recurrent course and the possibility of malignancy makes the problem of finding effective methods of diagnosis and treatment of this pathology urgent. Many methods of acting lesions have been proposed, but individual studies cannot demonstrate evidence of the advantages of one treatment method over another.
Objectives. On the basis of modern literature to determine effective methods of diagnosis and treatment of various forms of leukoplakia.
Methodology. The information bases are analyzed: PubMed, Elibrary, GoogleScholar, Medline, Cyberleninka. Combinations of keywords were used for the search.
Results. 593 articles were found according to the declared keywords. The number of articles remaining after applying the exclusion criteria is 58, after analyzing the annotations for compliance with the content of the stated review topic – 24. Analyzing the literature sources, it was determined that the diagnosis of the disease is carried out using clinical and histological studies. Elimination of the lesion with a laser occurs with a minimum of side effects, unlike traditional surgical treatment; recurrence of the disease occurs regardless of the chosen treatment method and is associated with the area of the lesion, its location and the presence of bad habits in patients; the most effective methods are argonoplasmic coagulation, erbium laser radiation and diode laser, allowing to achieve complete epithelialization in 7 days; also worthy alternative methods of treatment of oral leukoplakia are cryosurgery and photodynamic therapy.
Conclusions. In order to diagnose of oral mucosal leukoplakia, a clinical study with histological verification of the diagnosis is used. Conservative methods of treatment of oral leukoplakia are not always effective, especially with erosive and verrucose forms. In such a situation, a dentist is forced to resort to surgical excision of foci to prevent further development of the disease and transformation into a malignant neoplasm. Traditional methods of surgical treatment are gradually being replaced by more modern effective methods that allow obtaining an aesthetic result with a favorable course of the postoperative period.
SPECIFIC CHARACTERISTICS OF DENTAL HEALTH AND PERIODONTAL CONDITIONS IN ELDERLY WOMEN WITH DIABETES MELLITUS AND OSTEOPOROSIS
Authors: Elovicova Tat'yana , Ssablina Svetlana , Griroriev Sergey , Mandra Yuliya , Vol'hina Valentina , Marenkova Marina , Koshchev Anatoly 
Published: November 2022

Subject. The subject of this research is the dental health status and related diabetes mellitus and osteoporosis.
Objective. The objective of this research is to determine specific characteristics of defeat teeth and periodontal tissues, as well the clinical course of periodontitis in elderly patients with diabetes mellitus and osteoporosis.
Methodology. In a clinical examination of elderly women (aged 55–65) with periodontal inflammation and during their follow-ups at the stage of supporting therapy, three groups were formed (each with 20 subjects). The first group consisted of patients with Type II diabetes mellitus and osteoporosis; the second group consisted of osteoporotic patients; the third (reference) group consisted of patients who were the same age and considered themselves practically healthy at case control studies with follow-ups and periodontal inflammation in remission.
Results and discussion. DMFT index was 19.6 ± 2.35 for the patients in the first group, 1.31 times lower for the patients in the second group and 1.38 times lower for the patients in the third group. Russel’s periodontal index was 3.5 ± 0.8 in the first group, 1.46 times lower in the second group and 1.84 lower in the third group.
Conclusion. The research found the direct correlation between defeat teeth and more aggressive periodontitis in the patients with Type II diabetes mellitus and osteoporosis. Specific characteristics of defeat teeth are determined by higher Green-Vermillion oral hygiene indices, higher caries intensity with specific prevalence of “D” in both DMFT and DMFS indices. Increasing saliva viscosity decreases patient adaptation and adversely impacts on the organs of the oral cavity in the group of women with Type II diabetes mellitus and osteoporosis.
In silico Test Proteolytic Potential of Papain and Zingibain Enzymes Against Protein Forming Congenital and Senilis Cataracts
Authors: Damai Gangsar Lintas , Cahyana Nugraha Wahyu , Aziz Ayu Munawaroh 
Published: November 2022

Abstract
Phacoemulsification is cataract therapy’s gold standard with lowest complication rate and best visual outcome. However, phacoemulsification is expensive and difficult to use widely. Pathogenesis of cataract related to Crystalline P23T γD protein in congenital cataracts and β-amyloid protein in senile cataract. Papain enzymes and zingibain enzymes are cataract’s alternatives therapy with proteolytic effects that potentially lyse these proteins. Proteolytic injection with 30-gauge needle results in small, safe incision. Papain enzyme from Carica Papaya plant and zingibain enzyme from Zingiber Officinale plant which grows plentifully in Indonesia that becomes cheap source of proteolytic. This study’s purpose is to compare probability of binding energy based on Binding Interaction Model (BIM) between papain and zingibain enzymes against Crystalline P23T γD protein and β-amyloid protein with molecular docking. This research uses https://cluspro.bu.edu./login.php. BIM with lowest binding energy has most stable bond. Docking results show interaction probability between papain enzyme and Crystalline P23T γD protein has lowest binding energy of -730.4 kJ/mol at BIM 1. Probability of interaction between papain enzyme and β-amyloid protein has lowest binding energy of -697.2 kJ/mol at BIM 1. Probability of interaction between the enzyme zingibain and the crystalline P23T protein γD has lowest binding energy of -890.5 kJ/mol at BIM 2. Probability of interaction between the enzyme zingibain and the β-amyloid protein has lowest binding energy of -873.5 kJ/mol at BIM 0. It was concluded that the zingibain enzyme has the most stable probability of forming a stable bond to Crystalline P23T γD protein and β-amyloid protein.
Keyword:In silico, papain, zingibain, cataract
Cardiology Services During The Second Year Of The Covid-19 Pandemic
Authors: Laksono Sidhi , Kusharsamita Hillary 
Published: November 2022

Cardiology services have been affected by the COVID-19 pandemic. The consequences of the disease on cardiology services have not been studied in Indonesia, especially in the second year of this pandemic, as the surge in infections is currently declining. It is necessary to quantify the impact of the COVID-19 pandemic on cardiology services to evaluate whether or not cardiac services have returned to normal during this second year of the pandemic. The basis of research used in this study is a survey using a Google Form application. The technique to determine the research subjects carried out in this study is non-random sampling with the Purposive Sampling technique.One hundred and fifty-seven subjects were included in this study, with the majority gender of men (61.1%) as a clinical cardiologist (50.3%). Data were collected from several provinces in Indonesia from Jakarta to West Nusa Tenggara, with National Cardiovascular Center Harapan Kita as a majority hospital (n=15, 9.55%). There were generally sustained reductions in all aspects of cardiology service. However, the number of outpatients who underwent cardiac device implantation procedures did not increase. Telemedicine has been applied to 52.9% in the hospital where the subject works, yet the proportion of patients receiving telemedicine are less than 25%. During the second year of the COVID-19 pandemic, cardiology services need to establish new strategies to aid people with cardiovascular disease. More research is also needed in order to improve the efficacy of telemedicine in the future.
Keywords: Hospital Cardiology Service, Telemedicine, COVID-19 Pandemic
Wound Healing Activity of Galam Flower (Melaleuca Cajuputi Subsp. Cumingiana (Turcz.) Barlow) Methanol Extract Wistar Rats
Authors: Putri Kartika Veranisa , Novitasari Ika , Wardatina Hilma , Tangkeallo Lilis , Ashari Muhammad Dawud , Isnaini Isnaini - 
Published: November 2022

Wound is an incontinence condition of skin or mucosal epithelial tissue due to physical or thermal damage. One of the plants that has the potential as a wound healer is gelam (Melaleuca sp). Gelam flower methanol extract has antibacterial activity with a minimum inhibitory level of 1.7 mg/mL. This study aimed to analyze the wound healing activity of gelam flower methanol extract (Melaleuca sp.) in Wistar strain rats that were initiated by the wound seen from the histology of the rat skin. This research uses posttest only method with control group design. Thirty male wistar rats were divided into five groups consisting of a positive control group, a negative control group, 1% gelam flower extract gel, 2% gelam flower extract gel, and 4% gelam flower extract gel. Based on histological data, the positive control treatment group and 4% gel treatment group gave the same results. Both indicate that the skin tissue has begun to connect. The conclusions the three gelam flower methanol extract gel formulas showed wound healing activity and the 4% gelam flower methanol extract gel (Melaleuca Sp.) gave the greatest wound healing activity.
Keyword: Melaleuca sp, antibacterial activity, wound initiated healing
EARLY EFFECTS OF THE LATE PALEOZOIC CLIMATE TRANSITION ON SOIL ECOSYSTEMS OF THE APPALACHIAN BASIN (CONEMAUGH, MONONGAHELA, AND DUNKARD GROUPS): EVIDENCE FROM ICHNOFOSSILS
Authors: HEMBREE DANIEL I. 
Published: November 2022

ABSTRACT
The late Paleozoic transition is well represented by the upper Pennsylvanian to lower Permian Conemaugh, Monongahela, and Dunkard groups of the western Appalachian Basin (U.S.A.). These units contain abundant paleosols possessing suites of ichnofossils that serve as indicators of soil moisture, soil organic content, water table level, precipitation, and landscape stability. Analysis of these units can, therefore, be used to refine the details of how late Paleozoic terrestrial landscapes changed through time. A study along a 50 km west-east and a 40 km north-south transect through southeast Ohio and southwest West Virginia resulted in the recognition of 24 pedotypes with distinct ichnofossil assemblages. Ichnofossils include rhizoliths, Planolites, Palaeophycus, Taenidium, Scoyenia, Macanopsis, Skolithos, Cylindricum, cf. Psilonichnus, Arenicolites, mottles, and coprolites produced by various plants, gastropods, and larval-to-adult soil arthropods. Soil-forming environments include palustrine, levee, proximal to distal floodplain, interfluve, backswamp, marsh, and fen settings. An up-section shift in pedotypes from Argillisols to Vertisols and Calcisols as well as an overall increase in the diversity of pedotypes recorded a change in soil-forming conditions, resulting in a diverse landscape that changed significantly as mean annual precipitation rose and fell. An up-section increase in ichnofossil diversity in the paleosols and changes in ichnocoenoses suggests an increased dependence on the soil as a refuge and as a food resource. Overall, growing instability of the climate during the Pennsylvanian–Permian transition led to a more heterogeneous landscape that helped to promote colonization of a more diverse assemblage of soil organisms.
View-aware attribute guided network for vehicle re-identification
Authors: Tumrani Saifullah , Ali Wazir , Kumar Rajesh , Khan Abdullah Aman , Dharejo Fayaz Ali 
Published: November 2022

Abstract
Vehicle re-identification is one of the essential applications for intelligent transportation systems and urban surveillance. However, enormous variation in inter-class and intra-class resemblance creates a challenge for methods to distinguish between the same vehicles with different views. Additionally, diversified illumination and complicated environments create significant hurdles for the existing methods. We present a multi-guided learning method in this paper that uses multi-attribute and view point information, while also enhancing the robustness of feature extraction. The multi-attribute sub-network learns discriminative features like, i.e. color and type of vehicle. Moreover, the view predic-tor network adds extra information to the feature embedding and To validate the effectiveness of our framework, experiments on two benchmark datasets VeRi-776 and VehicleID are conducted. Experimental results illustrate our framework achieved comparative performance. VAAG CAR A CAR B Fig. 1 The figure shows two separate cars from distinct views from VeRi-776. Car A on the top row illustrates several views from various angles. Car B in the lower row has a diversity of viewpoints as well. These cars have very similar appearances, and it’s difficult to tell them apart. Car A appears to be different than its other views and identical to Car B from various perspectives.
"I was just concerned about getting pregnancy”: Attitudes toward Pregnancy and Contraceptive Use Among Adolescent Girls in Thika, Kenya
Authors: Daniel Afkera Kesete , Casmir Edinah , Oluoch Lynda , Micheni Murugi , Kiptinness Catherine , Wald Anna , Mugo Nelly Rwamba , Roxby Alison C. , Ngure Kenneth 
Published: November 2022

Abstract
Background
Adolescent girls and young women (AGYW) have a high incidence of unplanned pregnancies especially in low resource settings. AGYW assess overlapping risks of pregnancy, contraception, and STIs as they navigate relationships. Few studies have examined how AGYW consider comparative risks of their decisions around sexual and reproductive health in this context and how risk perception influences contraceptive use.
Methods
The Girls Health Study (GHS) is a longitudinal cohort study in Thika, Kenya assessing HSV-2 incidence in a cohort of AGYW aged 16–20 with not more than one lifetime sexual partners. Twenty in-depth interviews (IDIs) and 5 focus group discussions (FGDs) were conducted with a purposively selected subset of sexually active AGYW enrolled in the parent cohort. IDI interview guide focused on perspectives and decision-making around sexual and reproductive health. IDIs were conducted in both English and Kiswahili, transcribed and coded using inductive and deductive approaches to identify emergent themes.
Results
Participants described unintended pregnancies as undesirable, and AGYW reported prioritizing contraceptive methods that were effective and reliable in pregnancy prevention, even if not effective in preventing STI/HIV infection. Misconceptions about long-acting reversible contraceptives (LARCs), injectables, and daily oral contraceptive pills strongly disincentivized their use, with many AGYW citing concerns about infertility and structural damage to reproductive organs as deterrents. Though unlikely to use daily or long-term contraceptive methods in anticipation of sexual activity, participants reported that AGYW relied heavily on emergency contraceptive (EC) pills to prevent pregnancy immediately after unprotected sex.
Conclusions
Our research demonstrated that desire to avoid pregnancy was common, yet on its own was not enough to motivate uptake of long-term contraceptives. However, AGYWs generally favored the use of EC pills to prevent unintended pregnancy due to the EC pill’s convenience, cost-effectiveness and lower perceived risk of side effects. Understanding reasons for AGYW’s acceptance of the EC pill can help future interventions better target communication and counseling about contraceptives to influence key drivers of AGYW behavior and decision-making around sexual and reproductive health.
A new dynamics analysis model for five-axis machining of curved surface based on dimension reduction and mapping
Authors: Guo Minglong , wei zhaocheng , Wang Minjie , Zhao Zhiwei , Liu Shengxian 
Published: November 2022

Abstract
The equipment used in various fields contain an increasing number of parts with curved surfaces of increasing size. Five-axis CNC (Computer Numerical Control) milling is the main parts machining method, while dynamics analysis has always been a research hotspot. The cutting conditions determined by the cutter axis, tool path, and workpiece geometry are complex and changeable, which has made dynamics research a major challenge. For this reason, this paper introduces the innovative idea of applying dimension reduction and mapping to the five-axis machining of curved surfaces, and proposes an efficient dynamics analysis model. To simplify the research object, the cutter position points along the tool path were discretized into inclined plane five-axis machining. The cutter dip angle and feed deflection angle were used to define the spatial position relationship in five-axis machining. These were then taken as the new base variables to construct an abstract two-dimensional space and establish the mapping relationship between the cutter position point and space point sets to further simplify the dimensions of the research object. Based on the in-cut cutting edge solved by the space limitation method, the dynamics of the inclined plane five-axis machining unit were studied, and the results were uniformly stored in the abstract space to produce a database. Finally, the prediction of the milling force and vibration state along the tool path became a data extraction process that significantly improved efficiency. Two experiments were also conducted which proved the accuracy and efficiency of the proposed dynamics analysis model. This study has great potential for the online synchronization of intelligent machining of large surfaces.
Temperature variations in the mesosphere and lower thermosphere during geomagnetic storms with disparate durations at high latitudes
Authors: Wei Guanchun , Lu Jianyong , Wang Wenbin , Tian Yufeng , Li Jingyuan , Xiong Shiping , Sun Meng , Shen Fuzhen , Li Zheng , Zhang Hua , Cui Jingqi , Yang Chaolei , Yao Jingrui , Jiang Shuwen , Zhu Zhixin , Wang Jingye 
Published: November 2022

Abstract
Using the temperature data observed from SABER (the Sounding of the Atmosphere using Broadband Emission Radiometry), we investigate the response of the mesosphere and lower thermosphere (MLT) to two medium geomagnetic storms with disparate durations, on 20 April 2018 and 10 April 2022. The high-latitude MLT temperature increases can reach 40 K during April 2018 geomagnetic storm with a longer duration (Kp greater than 4 for 15 hours), while the temperature variations are less than 10 K for the April 2022 storm (Kp greater than 4 for 6 hours). To investigate the different temperature responses to disparate geomagnetic storm durations and understand what physical process results in this difference, we simulated the two events using the Thermosphere Ionosphere Mesosphere Electrodynamics General Circulation Model (TIMEGCM). The simulations show that more particles and energy input in longer-duration geomagnetic storms produce larger ion drag force and pressure gradient force at ~130 km, and then the enhanced two forces cause faster horizontal wind leading to larger horizontal divergence. Subsequently, the stronger downward vertical wind is transported to the MLT region (below 110 km) and ultimately makes greater temperature increases through adiabatic heating/cooling and vertical advection. Therefore, for the medium storms, the effects of the storm’s duration on the MLT temperature are more important than the storm’s intensity.