bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin-6 Receptor Blockade can Increase the Risk of Nonalcoholic Fatty Liver Disease: Indications From Mendelian Randomization
Authors: Li Shuxuan , Chen Lanlan , Lv Guoyue 
Published: June 2022

Background: Interleukin-6 receptor (IL-6R) blockade has been approved for inflammation-associated diseases and whether it is effective in treating non-alcoholic fatty liver disease (NAFLD) is still unknown.Methods: A target-based Mendelian randomization was performed to appraise whether inhibiting the IL-6 signaling pathway via IL-6R blockade can reduce the risk of NAFLD. The previously established genetic proxy SNP rs2228145 was mainly used to appraise the therapeutic effects and the genetic-predicted circulating IL-6 level was treated as the exposure with ∼30,000 samples. The genetic association between SNP rs2228145 (A &gt; C) and NAFLD was obtained from non-FinnGen GWAS (1,483 cases and 17,781controls) and FinnGen GWAS (894 cases and 217,898 controls). The causal effects were estimated using a Wald ratio method and were combined using a fixed-effects meta-analysis. Furthermore, the SNP rs12048091 was employed as another proxy in the sensitivity analysis.Results: The positive control analysis suggested the SNP rs2228145 can mimic the effects of IL-6R blockade where inhibiting IL-6 signaling can reduce the risk of rheumatoid arthritis [OR = 0.68 (0.58, 0.80)] and coronary heart disease [OR = 0.75 (0.68, 0.84)]. This Mendelian randomization analysis suggested that IL-6R blockade can adversely increase the risk of NAFLD in the non-FinnGen GWAS [OR = 1.99 (1.27, 3.13)] while not significant in the FinnGen consortium. The fixed-effects meta-analysis indicated inhibiting the IL-6 signaling pathway can reduce the risk of NAFLD [OR = 1.80 (1.26, 2.57)]. When including SNP rs12048091 as the genetic instrument, the meta-analysis using two genetic variants also indicated a similar effect on NAFLD [OR = 1.83 (1.32, 2.53)]. There was no heterogeneity in the whole analysis.Conclusion: Our Mendelian randomization suggested inhibiting the IL-6 signaling pathway via IL-6R blockade might increase the risk of NAFLD, suggesting IL-6R should play a protective role in NAFLD.
Elevated Admission Cardiac Troponin I Predicts Adverse Outcomes of Acute Type B Aortic Dissection after Endovascular Treatment
Authors: Zhao Kaiwen , Zhu Hongqiao , Zhang Lei , Liu Junjun , Pei Yifei , Zhou Jian , Jing Zaiping 
Published: June 2022

BackgroundThere is a lack of evidence about the predictive role of serum cardiac troponin I (cTnI) on the long-term adverse outcomes of acute type B aortic dissection (aTBAD) patients after thoracic endovascular aortic repair (TEVAR). In this study, we identified whether cTnI was an independent risk factor of 5-year adverse outcomes for aTBAD patients after TEVAR.MethodsWe reviewed consecutive aTBAD patients without previous heart disease who were admitted for TEVAR. The total study population was divided into the cTnI(+) group (≥0.03 ng/mL) and the cTnI(−) group (&lt;0.03 ng/mL) according to the time-dependent receiver operating characteristic curve analysis. The differences in clinical characteristics, operative details and clinical outcomes were compared between the two groups.ResultsThere was no difference in age and male prevalence between the two groups. Compared with the cTnI(−) group, the incidence of chronic kidney disease was higher in patients with cTnI ≥0.03 ng/mL. In addition, the cTnI(+) group presented with more frequent premature beats and non-myocardial-infarction ST-T segment changes. In terms of laboratory examinations, white blood cell counts, neutrophil counts, serum D-dimer and serum fibrin degradation products showed an increase in the cTnI(+) group, while lymphocyte and platelet counts showed a decrease in these patients. Patients with elevated cTnI suffered from increased risks of 5-year aortic-related adverse events (hazard ratio, HR = 1.822, 95% confidence interval, CI: 1.094–3.035; p = 0.021) and all-cause mortality (HR = 4.009, 95% CI: 2.175–7.388; p &lt; 0.001).ConclusionAmong aTBAD patients without previous heart disease, preoperative elevated cTnI identified patients at an increased risk of long-term adverse outcomes after TEVAR.
Case Report: Bilateral Biportal Endoscopic Open-Door Laminoplasty With the Use of Suture Anchors: A Technical Report and Literature Review
Authors: Zhu Chengyue , Wang Jing , Cheng Wei , Wang Dong , Pan Hao , Zhang Wei 
Published: June 2022

BackgroundUnilateral biportal endoscopy (UBE) is a newly developed technique for spine surgery. Owing to the convenience of nerve decompression and compatibility with open surgical instruments under endoscopic guidance, this technique has seen widespread global use. In this study, we first used modified UBE with suture anchor fixation for cervical laminoplasty in a 65-year-old female patient with good clinical outcomes.MethodsWe used bilateral biportal endoscopy (BBE) for cervical laminoplasty with suture anchor fixation in a patient with cervical stenosis. Under endoscopic guidance, a bilateral approach was used to make the gutter and lift the lamina door. After the lamina doors were opened, sutures were tied tightly using facia cannula and knot pusher. After confirming the solidarity of the open-door status, the drainage tube was inserted and the incisions were closed. The patient’s pre- and postoperative radiological and clinical results were evaluated.ResultsPostoperative Japanese Orthopaedic Association (JOA) and Neck Disability Index (NDI) scores were improved clinically, and cervical canal was decompressed radiologically.ConclusionsBBE laminoplasty combined with suture anchor fixation showed a favorable clinical and radiological result and appears to be a safe and effective technique for cervical stenosis.
Le nom propre concept réfractaire à l'innovation lexicale
Authors: Polge Henri 
Published: June 2022

Les croisements phonétiques (homophonisations) n'engendrent que rarement des évictions lexicales. En revanche, les croisements sémantiques (synonymisations) en engendrent beaucoup. Il n'y a pourtant pas contradiction entre les deux phénomènes, mais identité foncière, la tendance générale étant à l'économie du vocabulaire chaque fois qu’un besoin en sens inverse ne se fait pas sentir impérativement.
L'absence de croisements sémantiques (état d'a-synonymie parfaite) est aussi importante à considérer que les croisements eux-mêmes. Elle rend compte, en référence à la notion de parallélisme diachronique (inverse de celle de croisement), de la stabilité d'un certain nombre de vocables, assujettis aux seuls effets de l'érosion phonétique. Elle n'en procède pas moins du principe général d’économie lexicale.
L'observation conjointe de ces phénomènes conduit à considérer le nom propre comme assimilable aux appellations afférentes à des concepts généralement rebelles à l'innovation lexicale.
A LITERATURA CLÁSSICA NA FORMAÇÃO DO LEITOR ADOLESCENTE NA ESCOLA
Authors: Lazo Lara Jatkoske 
Published: June 2022

ResumoObjetiva-se apresentar, pela pesquisa narrativa, aspectos do desenvolvimento do leitor/autor adolescente pela leitura coletiva de clássicos literários. Conclui-se que são potências formativas de construção coletiva e integralização de conhecimentos. Palavras-chave: palavra e discurso; metodologia; leitura, estética e educação. AbstractIt aims to present through narrative research aspects of the development of the adolescent reader/author, through the collective reading of literary classics. It is concluded that they are formative powers for the collective construction and integration of knowledge. Keywords: word y discourse; methodology; reading, aesthetics and education. ResumenEl objetivo es presentar, por investigación narrativa, los aspectos del desarrollo del lector / autor joven mediante la lectura colectiva de los clásicos literarios. Se concluye que son poderes formativos de la construcción colectiva e integración del conocimiento. Palabras clave:palabra y discurso; metodología; lectura, estética y educación.
A FORMAÇÃO CONTINUADA PARA A APRENDIZAGEM DA DOCÊNCIA: UM ATO RESPONSIVO
Authors: Radvanskei Sônia i De Fátima , Hagemeyer Regina Cely De Campos 
Published: June 2022

O objetivo deste artigo focaliza-se nas interlocuções entre a formação continuada de professores alfabetizadores, proporcionada por uma rede municipal brasileira de ensino, e as influências dessa formação na construção da docência desses profissionais. Propõe-se pela pesquisa qualitativa, a partir dos instrumentos metodológicos da entrevista semiestruturada, roda de conversa, observação participante e questionário semiestruturado, analisar de dados obtidos nos discursos responsivos das professoras alfabetizadoras. Para a fundamentação desta análise, foram utilizados os referenciais teóricos dos autores Bakhtin (2011), Kramer (2010), Maldonado (2002), Brotto (2006) e Mizukami (2013), Shulman (1986), entre outros. Percebeu-se nessas análises, que o professor constrói sua profissão e suas práticas de alfabetizadores, em suas relações sociais, em suas experiências cotidianas de alfabetizar, nas interlocuções e no diálogo com os processos da formação continuada da qual participa, durante suas trajetórias no âmbito escolar. Nessa relação, as demarcações entre a pessoa que constrói a profissão e função de alfabetizador/a e a formação inicial e continuada, se coadunam dialogicamente, criando um espaço de aprendizagem docente.
A LITERATURA COMO ELEMENTO DE FORMAÇÃO PARA EDUCAÇÃO ÉTNICO-RACIAL
Authors: Silva Rosangela Maria 
Published: June 2022

O presente artigo explicitará as principais considerações realizadas na dissertação de mestrado intitulada “Ressignificando o uso da literatura para educação étnico-racial” apresentada à Faculdade de Educação da Universidade de São Paulo sob orientação da professora doutora Dislane Zerbinatti Moraes. A pesquisa discutiu literatura e formação humana, considerando os aspectos que envolvem a obrigatoriedade dos estudos de cultura africana e afro-brasileira na escola, sob a perspectiva da Lei 10.639 de 2003, alterada pela Lei 11.645 de 2008. Os objetivos da pesquisa encontram-se relacionados ao contexto de realização da lei, suas condições de elaboração dentro da escola e retomada de seus sentidos de aplicabilidade. A pesquisa caracterizou-se por ser qualitativa com aspectos que a inserem dentre os estudos etnográficos e propôs um estudo de caso que envolveu os sujeitos de pesquisa, alunos do 7º ano do Ensino Fundamental de uma escola municipal da cidade de São Paulo. O referencial teórico foi constituído por autores que estudam e problematizam as questões étnicos-raciais relacionadas ao negro e discutem o uso da Literatura no desenvolvimento do processo de humanização do indivíduo. Dessa forma, pudemos explicitar em nossas considerações finais que ressignificar o uso da literatura na escola compreende direcioná-lo na condição de proporcionar conhecimento e transformação no indivíduo a partir de uma experiência significativa. Palavras-chave: Relações Étnicas; Literatura; Práticas escolares.
JOÃO E SEUS LAÇOS DE FAMÍLIA
Authors: Souza Dayana Coelho , Assolini Filomena Elaine Paiva 
Published: June 2022

Este artigo teve por objetivo analisar o discurso do adolescente João sobre família à luz da psicanálise e análise do discurso. Ele interpretou que família está associado às palavras unida e regras, seu discurso apresentou questões sobre uma maior permissividade e frouxidão nos laços.
DIÁLOGOS COM ESCRITORAS NEGRAS: POR UMA PLURALIDADE NA LEITURA
Authors: Souza Cunha Moreira Marisa De 
Published: June 2022

Este ensaio teórico pretende discutir um dos caminhos possíveis para a pluralidade leitora, pois concentra-se na contribuição do pensamento de escritoras negras. A problemática consiste em olhar para a leitura, no sentido de refletir sobre a in(visibilidade) de algumas mulheres que escrevem e contribuem tanto na área literária como na filosófica. A análise considera o contexto social brasileiro e suas contradições, principalmente no que se refere ao acesso aos bens culturais, considerando que as condições de desenvolvimento, inserção profissional e divulgação de trabalho não são igualitárias. Essa divisão econômica e, consequentemente de classes, reflete no mercado editorial, que reproduz as questões de gênero e raça presentes no cotidiano do país. Desse modo, o trabalho de caráter bibliográfico apresenta como considerações finais a potencialidade que as obras de escritoras negras possuem no sentido de contribuir para uma pluralidade de leitura, no processo social e na ampliação dos modos de ver e sentir a cultura afro-brasileira. Palavras-chave: leitura, pluralidade leitora, escritoras negras, processo social
Les collocations d’intensité Adj как N et Adj до N
Authors: Beliakov Vladimir 
Published: June 2022

Dans le présent article, nous examinons deux types d’associations collocatives d’intensité Adj как « comme » N et Adj до « jusqu’à » N appliquées aux adjectifs qualifiant l’aspect physique de l’être humain. L’objectif de notre étude est de mettre en évidence les facteurs d’attraction mutuelle des éléments des collocations, d’essayer de les expliquer et de les prédire afin d’éviter les traitements au cas par cas et de montrer ainsi que ces structures constituent des moules sémantiques particulièrement adaptés pour la création de collocations dans le discours. Plus précisément nous démontrons à travers la description des relations sémantiques entre les adjectifs et les noms quelques principes explicatifs de leur combinatoire.
Blockchain for the Cybersecurity of Smart City Applications
Authors: cheikhrouhou omar , Amdouni Ichrak , Mershad Khaleel , Ammi Meryem , Nguyen Tuan 
Published: June 2022

<p>Cybersecurity is an inherent characteristic that should be addressed before the large deployment of smart city applications. Recently, Blockchain appears as a promising technology to provide several cybersecurity aspects of smart city applications. This paper provides a comprehensive review of the existing blockchain-based solutions for the cybersecurity of the main smart city applications, namely smart healthcare, smart transportation, smart agriculture, supply chain management, smart grid, and smart homes. We describe the existing solutions and we discuss their merits and limits. Moreover, we define the security requirements of each smart city application and we give a mapping of the studied solutions to these defined requirements. Additionally, future directions are given. We believe that the present survey is a good starting point for every researcher in the fields of cybersecurity, blockchain, and smart cities.</p>
Cooperative Body Channel Communications for Energy Efficient Internet of Bodies
Authors: Alamoudi Abeer , Celik Abdulkadir , Eltawil Ahmed 
Published: June 2022

<p>The Internet of Bodies is a network formed by wearable, implantable, ingestible, and injectable smart devices to collect physiological, behavioral, and structural information from the human body. Thus, the IoB technology can revolutionize the quality of human life by using these context-rich data in myriad smart-health applications. Radio frequency (RF) transceivers have been typically preferred due to their availability and maturity. However, for most RF standards (e.g. Bluetooth Low Energy), the highly radiative omnidirectional RF propagation (even at the lowest settings) reaches tens of meters of coverage, thereby reducing energy efficiency, causing interference and co-existence issues, and raising privacy and security concerns. On the other hand, body channel communication (BCC) confines low-power and low-frequency (10 kHz-100 MHz) signals to the human body, leading to more secure and efficient communications. Since energy efficiency is one of the critical design parameters of IoB networks, this paper focuses on energy-efficient orthogonal body channel access (OBA) and non-orthogonal body channel access (NOBA) schemes with and without cooperation. To this aim, three main BCC topologies are presented; point-to-point channel, medium access channel, and broadcast channel. These topologies are then used as building blocks to create IoB networks relying on OBA and NOBA schemes for downlink (DL) and uplink (UL) traffic. For all schemes and traffic directions, optimal transmit power and phase time allocations are derived in closed-form, which is essential to reduce energy consumption by eliminating computational power. The closed-form expressions are further leveraged to obtain maximum network size as a function of data rate requirement, bandwidth, and hardware parameters. </p>
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Books of Ukraine in the mirror of the state bibliography
Authors: Ocheretiana Lydiіa 
Published: June 2022

The article examines the thematic distribution of publications in the database of the state bibliography "Chronicle of Books" for 2020, which contains 17 709 bibliographic records according to the classes of UDC.
A comparative analysis of the number of publications by sections of the UDC to determine the thematic focus of book publishing in Ukraine in 2020 in accordance with the branches of science. The analysis revealed that the largest number of records belongs to classes 0, 3, 6 and 8 — 13 949 titles, or 79% of the total number of publications in 2020. These are works of art and literature and books on education, law, economics, medicine, science. The remaining sections together account for less than half of all database records — 3760 records, or 21%.
Analisis Perlakuan Pajak Penghasilan Pasal 23 Atas Jasa untuk Menetapkan Fee Fintech Peer to Peer Lending PT Esta Kapital Fintek pada PT Esta Dana Ventura
Authors: Mulyani Sri , Efriadi Adi Rizfal 
Published: June 2022

The purpose of this study is to analiyze how to calculations determination of Fintech Peer to Peer Lending fees conducted by PT Esta Dana Ventura from coorporation with PT Esta Kapital Fintek as well as what treatment income tax article 23 on this fee is in accordance with the law applicable taxation. The research design used in this study is to use qualitative methode. Income tax treatment article 23 on Fintech Peer to Peer Lending services starting from recording and the deducation is in accordance with the applicable tax regulation, namly Law No. 36 of 2010. This can be seen from the amount of taxes which was deducated for the Peer to Peer Lending services of PT Esta Dana Ventura equal from the amount of tax withheld by the tax office. The size taxes that must be paid by PT Esta Dana Ventura in 2019 for Fintech services is Rp. 57.875.506.
Penerapan Model Bisnis pada Waskita Beton Precast Tbk
Authors: Wibowo Kuncoro , Pradopo Loeky Rono 
Published: June 2022

Proyek pembangunan di Indonesia sangat besar, hal ini terlihat dari banyaknya pekerjaan di Indonesia, diantaranya pembangunan jalan layang Jakarta Bekasi via Kali Malang, perpanjangan jalan tol di sekitar TB. Simatupang, pembangunan gedung di Kemayoran, serta beberapa tempat yang menggunakan beton pracetak. Banyak hal konkrit yang diperlukan untuk mendukung kegiatan tersebut. Menanggapi tantangan tersebut, PT, Waskita Beton Precast Tbk. dengan mengembangkan beberapa pabrik pembuatan Beton Pracetak di beberapa tempat di pulau Jawa. Dengan melihat beberapa pertimbangan tersebut dan kondisi ketidakpastian yang akan dihadapi mulai dari fluktuasi harga, tren permintaan dan faktor lain yang dapat mempengaruhi proses produksi serta potensi kerugian operasional pada proses produksi, penulis menggunakan metode analisis Business Model Kanvas untuk melihat bentuk dan model bisnis yang digunakan oleh Waskita Beton Precast Tbk. Model bisnis yang diterapkan apakah sudah mampu untuk membuat perusahaan dapat bertahan dalam jangka panjang dan menghadapi masalah di saat ini. Rancangan kanvas model bisnis yang dibuat dapat dipakai sebagai kontrol pengambilan keputusan serta kebijakan yang nantinya digunakan sebagai pedoman dalam aktifitas agar semua terlaksana dan terkontrol dengan baik serta dapat mengelola semua kekuatan kelemahan dengan tambahan analisis SWOT agar dapat meminimalisir potensi kerugian serta mengambil profitabilitas dari peluang bisnis yang ada. Hasil penelitian ini menunjukkan bahwa Model bisnis sangat diperlukan untuk membuat perusahaan dapat mencapai visi dan misi serta membuat perusahaan dapat bertahan untuk masa sekarang dan di masa depan.

Kata Kunci: Bisnis model kanvas analisis, SWOT analisis, Beton precast, Studi kasus.
Peranan Pemahaman E-Commerce dan Sistem Informasi Akuntansi Bagi Kewirausahaan
Authors: Lovita Erna , Susanty Febyana 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui pengaruh pemahaman E-Commerce dan pemahaman sistem informasi akuntansi (SIA) terhadap minat berwirausaha. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan asosiatif. Teknik pengumpulan sampel menggunakan metode purposive sampling yaitu mahasiswa jurusan Akuntansi tahun angkatan 2015-2016 yang telah mengikuti mata kuliah sistem informasi akuntansi. Jumlah sampel sebanyak 149 responden yang berasal dari 7 Perguruan Tinggi Swasta yang berada di Jakarta. Teknik pengumpulan data dengan cara menyebarkan kuesioner menggunakan google forms yang telah diuji validitas dan reliabilitasnya. Teknik analisis data yang digunakan adalah menggunakan hipotesis dan koefesien determinasi menggunakan program SPSS versi 25. Hasil penelitian ini membuktikan bahwa pemahaman E-Commerce dan pemahaman SIA berpengaruh positif terhadap minat berwirausaha. Bagi mahasiswa pemahaman E-Commerce dan pemahaman SIA akan mendorong peluang lebih besar untuk berhasil menjalankan wirausahanya.

Kata Kunci: E-Commerce, Sistem Informasi Akuntansi, minat berwirausaha
Penentuan Keputusan Mahasiswa untuk Menabung di Perbankan Syariah
Authors: Sunarsih Uun , Wijayantie Meitry Nurachma 
Published: June 2022

Mahasiswa menjadi salah satu sumber dana pihak ketiga bagi perbankan syariah. Penelitian ini bertujuan untuk mengetahui pengaruh disposable income, dan sharia compliance terhadap keputusan menabung di perbankan syariah dengan literasi keuangan syariah sebagai variabel moderasi. Jenis penelitian ini adalah deskriptif dengan pendekatan kuantitatif. Data diperoleh dengan menyebarkan kuisoner kepada mahasiswa di DKI Jakarta. Sampel dengan convenience sampling, dan diperoleh 350 responden. Hasil penelitian menunjukan bahwa disposable income dan sharia compliance berpengaruh terhadap keputusan menabung di perbankan syariah. Hal ini menunjukkan bahwa semakin tinggi disposable income mahasiswa dan semakin baik bank syariah mematuhi ketentuan syariah maka keputusan mahasiswa untuk menabung di perbankan syariah meningkat. Literasi keuangan syariah bukan merupakan variabel moderasi pengaruh disposable income terhadap keputusan menabung di perbankan syariah, tetapi merupakan variabel moderasi pengaruh sharia compliance terhadap keputusan menabung di perbankan syariah. Artinya Artinya meskipun tingkat literasi keuangan syariah baik namun jika disposable income yang dimiliki tidak mencukupi untuk menabung maka tidak akan mempengaruhi mahasiswa mengambil keputusan untuk menabung, tetapi dengan memiliki literasi keuangan syariah yang baik maka mahasiswa lebih memperhatikan penerapan sharia compliance di perbankan syariah dan ini akan mempengaruhi keputusan menabung di perbankan syariah.

Kata Kunci: Disposable Income, Sharia Compliance, Keputusan Menabung dan Literasi Keuangan Syariah