Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes by Sodium–Glucose Cotransporter 2 Inhibitor Treatment: The FIDELITY Analysis
Authors: Rossing Peter , Anker Stefan D. , Filippatos Gerasimos , Pitt Bertram , Ruilope Luis M. , Birkenfeld Andreas L. , McGill Janet B. , Rosas Sylvia E. , Joseph Amer , Gebel Martin , Roberts Luke , Scheerer Markus F. , Bakris George L. , Agarwal Rajiv ,   on behalf of the FIDELIO-DKD and FIGARO-DKD Investigators, Aizenberg Diego , Bartolacci Inés , Besada Diego , Bittar Julio , Chahin Mariano , Elbert Alicia , Gelersztein Elizabeth , Liberman Alberto , Maffei Laura , Pérez Manghi Federico , Sanabria Hugo , Vallejos Augusto , Viñes Gloria , Wassermann Alfredo , Abhayaratna Walter , Acharya Shamasunder , Ekinci Elif , Lee Darren , MacIsaac Richard , Mann Mah Peak , Nelson Craig , Packham David , Pape Alexia , Roger Simon , Stephenson Hugo , Suranyi Michael , Wittert Gary , Vale Elizabeth , Colman Peter , Colquhoun David , Ellis Chris , Joshua Kim , Pedagogos Eugenia , Regal Paul , Topliss Duncan , Vandeleur James , Verjans Johan , Wittert Gary , Wynne Katie-Jane , Clodi Martin , Ebenbichler Christoph , Fliesser-Görzer Evelyn , Hanusch Ursula , Krebs Michael , Lhotta Karl , Ludvik Bernhard , Mayer Gert , Neudorfer Peter , Paulweber Bernhard , Prager Rudolf , Preiß Wolfgang , Prischl Friedrich , Schernthaner Gerit-Holger , Sourij Harald , Wiesholzer Martin , Drexel Heinz , Oberbauer Rainer , Schönherr Hans-Robert , Doubel Peter , Engelen Wendy , Gillard Pieter , Hougardy Jean-Michel , Krzesinski Jean-Marie , Maes Bart , Speeckaert Marijn , Stas Koen , van Gaal Luc , Vanbelleghem Hilde , Duyck Francis , Scheen André , Antunes Daniela , Botelho Roberto , Brito Claudia , Canani Luis , Canziani Maria Eugenia , Cerqueira Maria , de Paula Rogerio , Eliaschewitz Freddy , Figueiredo Carlos Eduardo , Forti Adriana , Hissa Miguel , Leite Maurilo , Lima Emerson , Noronha Irene , Paolino Bruno , Paschoalin Nathalia , Paschoalin Raphael , Pecoits Filho Roberto , Pereira Marcio , Portes Evandro , Precoma Dalton , Rea Rosangela , Riella Miguel , Salles Joao Eduardo , Vasconcellos Eduardo , Vencio Sergio , Bacci Marcelo , Maia Lilia , Villacorta Aline , Apostolova Emiliya , Boshnyashka Radostina , Farah Ghassan , Georgiev Dimitar , Gushterova Valentina , Klyuchkova Neli , Lucheva Mariya , Manova Petya , Minkova Dotska , Nonchev Boyan , Pichmanova Mariyana , Prakova Zhulieta , Rangelov Rangel , Rashkov Rosen , Stanchev Pavel , Stoyanovska-Elencheva Bilyana , Tagarev Zhivko , Temelkova-Kurktschieva Theodora , Vasileva Svetla , Yoncheva-Mihaylova Mariana , Marinchev Angel , Miteva Mariya , Barre Paul , Carlson Brian , Conway James , Cournoyer Serge , Dumas Richard , Fikry Sameh , Goluch Richard , Hamet Pavel , Hart Randolph , Henein Sam , Liutkus Joanne , Madore Francois , Martinho Valdemar , Mazza Giuseppe , McFarlane Philip , O’Keefe Dennis , Peterson Sean , Schwartz Daniel , Shu Daniel , Steele Andrew , Tellier Guy , Tennankore Karthik , Tobe Sheldon , Tsoukas George , Tytus Richard , Vitou Louise , Walsh Michael , Weisnagel Stanley , Wilderman Igor , Yale Jean-Francois , El Boreky Fadia , Kelly Alan , Leiter Lawrence , Teitelbaum Ivor , Cobos Jorge , Godoy Juan , González Fernando , Lobos Sergio , Palma Juan Carlos , Prieto Dominguez Juan Carlos , Reyes Eliana , Romero Carmen , Saavedra Victor , Vega Mario , Medina Marcelo , Varleta Paola , Bu Ruifang , Cai Hanqing , Chen Nan , Chen Qinkai , Chen Dejun , Cheng Jinluo , Dong Youping , Dong Junwu , Guan Tianjun , Hao Chuanming , Huang Wen , Jiang Fangfang , Lei Minxiang , Li Ling , Li Zhonghe , Li Xuemei , Li Jingmei , Li Yan , Liang Xinling , Liang Bo , Liu Fang , Liu Yinghong , Liu Yuantao , Liu Zhihong , Long Gang , Lu Guoyuan , Lu Weiping , Lu Yibing , Luo Ping , Ma Jianhua , Mo Zhaohui , Niu Jianying , Peng Ai , Shen Jiansong , Shen Feixia , Shi Bingyin , Su Qing , Sun Zhuxing , Tang Shuifu , Tong Nanwei , Wang Hao , Wang Xinjun , Wang Guixia , Wang Jianqin , Wang Yangang , Wang Li , Wei Jiali , Wu Tianfeng , Wu Chaoqing , Xing Changying , Xiong Fei , Xu Xudong , Xu Ning , Yan Tiekun , Yang Jinkui , Yin Aiping , Zeng Longyi , Zhang Hao , Zhang Yanlin , Zhang Ying , Zhao Wenjing , Zhao Zhiquan , Zheng Hongguang , Zhong Ling , Zhu Dalong , Zhuang Yongze , Du Yuming , Fang Yi , Guo Weiying , Jiang Sheng , Kuang Jian , Li Dongmei , Li Hongmei , Li Yinan , Li Yuxiu , Liu Jian , Liu Yu , Miao Heng , Peng Wen , Wang Lihua , Xu Mingtong , Zhong Liyong , Zhu Jun , Arango Clara , Barrera Sandra , Beltrán López Nelly , Benitez Diego , Blanco Guillermo , Cadena Andrés , Coronel Julian , Cure Carlos , Durán Carlos , González Alexander , Guzmán Gustavo , Hernández Eric , Ibarra Jaime , Jaramillo Carlos , Jaramillo Nicolás , Kattah William , Molina Dora , Sánchez Gregorio , Terront Mónica , Trujillo Freddy , Urina Miguel , Vargas Ruben , Villegas Iván , Yupanqui Hernán , Arcos Edgar , Aroca Gustavo , Barreto Germán , Bermudez Andres , Botero Rodrigo , Cárdenas Tatiana , Figueroa Wilmer , Jaramillo Mónica , Liévano Manuel , López Mónica , Molina Dora , Rosero Ricardo , Trillos Pedro , Alferi Dino , Brada Michal , Brezina Jiri , Bucek Petr , Edelsberger Tomas , Gulakova Drahomira , Hasalova Zapletalova Jitka , Hola Olga , Hornova Lucie , Houdova Jana , Hrmova Helena , Karasek David , Kopecka Sarka , Kovar Richard , Krcova Eva , Kuchar Jiri , Kutejova Vlasta , Lubanda Hana , Matyasek Ivo , Mokrejsova Magdalena , Okenka Libor , Prazny Martin , Pumprla Jiri , Tomanek Pavel , Andersen Ulla , Andries Alin , Bech Jesper , Faber Jens , Gislason Gunnar , Hangaard Jørgen , Jaroslaw Pacyk Grzegorz , Juhl Claus , Krarup Thure , Lindhardt Morten , Madsbad Sten , Nielsen Joan , Pedersen-Bjergaard Ulrik , Poulsen Per , Rasmussen Ole , Rossing Peter , Schousboe Karoline , Gram Jeppe , Lauridsen Thomas , Pedersen Erling , Thorsteinsson Birger , Flöjt Päivi , Honkasalo Mikko , Honkasalo Mikko , Humaloja Kari , Kananen Kristiina , Kantola Ilkka , Koistinen Arvo , Korsoff Pirkko , Lahtela Jorma , Nieminen Sakari , Nieminen Tuomo , Sadeharju Karita , Strand Jorma , Sulosaari Sakari , Cariou Bertrand , Chantrel François , Clavel Sylvaine , Combe Christian , Fauvel Jean-Pierre , Gallouj Karim , Gouet Didier , Guerci Bruno , Guerrot Dominique , Hourmant Maryvonne , Klein Alexandre , Mariat Christophe , Marre Michel , Mesbah Rafik , Le Meur Yannick , Monier Arnaud , Moranne Olivier , Roussel Ronan , Serusclat Pierre , Vendrely Benoit , Verges Bruno , Zaoui Philippe , Axthelm Christoph , Bergmann Andreas , Birkenfeld Andreas L. , Braun Hermann , Busch Klaus , Contzen Christel , Degenhardt Stefan , Derwahl Karl , Giebel Thomas , Hagenow Andreas , Haller Hermann , Hasslacher Christoph , Horacek Thomas , Jungmair Wolfgang , Kloos Christof , Koch Thorsten , Krüger Thilo , Mühlfeld Anja , Müller Joachim , Pfützner Andreas , Pistrosch Frank , Rinke Andrea , Rose Ludger , Rump Lars , Schettler Volker , Schiefke Ingolf , Schlichthaar Heike , Schröppel Bernd , Schöll Norbert , Schubert Kristin , Schürholz Thomas , Sigal Helena , Stemler Lutz , Strack Georg , Täschner Heidrun , Toursarkissian Nicole , Tschöpe Diethelm , Ulmer Achim , van der Giet Markus , Wanner Christoph , Winkelmann Bernhard R. , Boletis Ioannis , Dimitriadis George , Hatziagelaki Erifili , Iatrou Christos , Ioannidis Ioannis , Kounadi Theodora , Makriniotou Ioanna , Papadopoulou Dorothea , Papagianni Aikaterini , Passadakis Ploumis , Piaditis George , Stefanidis Ioannis , Pang Ip Tai , Lee Paul , Luk On Yan Andrea , Ma Ronald , Chow Wing Sun , Wang Angela , Yeung Vincent , Bajcsi Dora , Danos Peter , Harcsa Eleonora , Kalina Akos , Kazup Szilvia , Keltai Katalin , Kirschner Robert , Kiss Julianna , Kovacs Laszlo , Lamboy Beata , Literati-Nagy Botond , Mileder Margit , Nagy Laszlo , Noori Ebrahim , Nyirati Gabor , Petro Gizella , Schneider Karoly , Simon Judit , Szocs Albert , Vasas Szilard , Wudi Krisztina , Zilahi Zsolt , Zsom Marianna , Eustace Joe , Holian John , Reddan Donal , O’Meara Yvonne , Abramof Ness Rosane , Adawi Faiad , Armaly Zaher , Atar Shaul , Bashkin Amir , Ben Chetrit Sydney , Berar Yanay Noa , Chernin Gil , Darawsha Mahmud , Efrati Shai , Elias Mazen , Farber Evgeny , Glandt Mariela , Grossman Ehud , Halabi Majdi , Harman-Boehm Ilana , Khazim Khaled , Liberty Idit , Minuchin Oscar , Mosenzon Ofri , Nakhoul Farid , Nimer Assy , Schwartz Doron , Wainstein Julio , Yagil Yoram , Zukermann Robert , Avogaro Angelo , Battaglia Giovanni Giorgio , Tiziano Bevilacqua Maurizio , Bonora Enzo , Bossi Carlo Antonio , Calabrò Paolo , Cavalot Franco Luigi , Cimino Roberto , Gennaro Cozzolino Mario , David Salvatore , Emdin Michele , Fiaccadori Enrico , Fiorina Paolo , Giorda Carlo Bruno , Gregorini Maria Cristina , La Manna Gaetano , Maggi Davide Carlo , Manti Roberta , Meregalli Giancarla , Pani Antonello , Parvanova Aneliy Ilieva , Perico Norberto , Piatti PierMarco , Pisani Antonio , Pontiroli Antonio Ettore , Ponzani Paola , Santorelli Gennaro , Santoro Domenico , Scanziani Renzo , Teatini Ugo , Tonolo Giancarlo , Trevisan Roberto , Veronelli Anna Maria , Viviani Giorgio Luciano , Araki Hideo , Bando Yukihiro , Ebisui Osamu , Fujita Naruhiro , Fukasawa Hirotaka , Furuya Ryuichi , Hamamoto Yoshiyuki , Hamasaki Akihiro , Hasegawa Kotaro , Hatazaki Masahiro , Hayashi Terumasa , Higashi Takayuki , Hirohata Yoshihide , Horinouchi Shuji , Hoshi Ayumu , Imoto Hirofumi , Inagaki Akemi , Inagaki Masayuki , Inaguma Daijo , Inoue Toshihiko , Ishii Masao , Ishiko Tamayo , Isono Motohide , Jinnouchi Hideaki , Kanai Hidetoshi , Kanda Daisuke , Kanehara Hideo , Kashima Masayuki , Kataoka Yuko , Katayama Shigehiro , Kato Kiyoe , Katsuki Takeshi , Kawamitsu Katsunori , Kawasaki Satsuki , Kikuchi Fumi , Kikuchi Hidetoshi , Kishimoto Rui , Kobayashi Kunihisa , Koide Junko , Komi Rieko , Kubota Miyuki , Kuriya Genpei , Kurose Takeshi , Kusano Yoshiro , Maeda Hajime , Matsubayashi Sunao , Matsumoto Kazunari , Matsumura Naoya , Matsuo Yasuto , Matsuoka Naoki , Miyaoka Hiroaki , Miyata Satoshi , Morita Takeshi , Murakami Isao , Murao Satoshi , Nakamura Udai , Nakayama Mikihiro , Nakazawa Jun , Nohara Sakae , Nomiyama Takashi , Noritake Masayuki , Oda Yoshiaki , Ogiwara Takayuki , Ohashi Hiroshi , Okamoto Hideki , Okino Shinichi , Osonoi Takeshi , Sasaki Nobuhiro , Sayo Yoshitaka , Sekigami Taiji , Shibasaki Taro , Shibata Hirotaka , Shimoyama Tatsushi , Shinoda Junji , Sobajima Hiroshi , Sugitatsu Kazuya , Sugiura Toshiyuki , Sugiyama Toru , Suzuki Daisuke , Suzuki Hiroyuki , Suzuki Masaaki , Takeda Asami , Tanaka Asami , Tanaka Seiichi , Tsunematsu Izumi , Ueda Yasuo , Uekihara Soichi , Ujihara Makoto , Yajima Ken , Yamada Daishiro , Yamada Masayo , Yamagata Kazuo , Yamakawa Ken , Yamakawa Fumiko , Yamasaki Yoshimitsu , Yambe Yuko , Yanagida Taihei , Yanai Hidekatsu , Yanase Toshihiko , Yasuda Tetsuyuki , Kriauciuniene Dovile , Lasiene Jurate , Navickas Antanas , Radzeviciene Lina , Urbanaviciene Egle , Urbonas Gediminas , Velaviciene Audrone , Abd Ghani Rohana , Azizah Aziz Nor , Lee Li Yuan , Loh Chek Loong , Mohd Ali Norhaliza , Mohd Noor Nurain , Nur Fatnoon Nik , Ahmad Nik , Ratnasingam Jeyakantha , Hasnul Wan , Bin Wan Hasan Halimi , Mohd Izani Wan , Mohamed Wan , Najme Khir Rizmy , Mohamad Masni , Tan Tong Boon Alexander , Avila Pardo Sandro , Bastidas Adrian Miriam , Wong Alfredo Chew , Escobedo de la Peña Jorge , Fanghänel Salmón Guillermo , González Gálvez Guillermo , Gutiérrez Ochoa Ramiro , Irizar Santana Saúl , Madero Rovalo Magdalena , Méndez Machado Gustavo , Nevarez Ruiz Luis , Ramos Ibarra Denisse , Ramos López Gabriel , Sauque Reyna Leobardo , Solache Ortiz Gustavo , Valdez Ortiz Rafael , Villagordoa Mesa Juan , Alpizar Salazar Melchor , García Hernández Pedro , González José , Lazcano Soto José , Saldaña Mendoza Arturo , Irizar Santana Sergio , González Vilchis Elvira , Bakker R.C. , Barendregt J.N.M. , Boonstra A.H. , Bos Willem , Brouwer C.B. , van Buren M. , Gansevoort Ron , Kooy Adriaan , Krekels Marielle , van Leendert Ruud J.M. , Lieverse Louis A.G. , Luik P.T. , Penne E. Lars , Smak Gregoor Peter , Vogt Liffert , van den Born Bert-Jan , Baker John , Crawford Veronica , Cutfield Rick , Dunn Peter , Krebs Jeremy , Nirmalaraj Kingsley , Scott Russell , Smuts Nine , Titchener Janet , Eriksen Erik , Finnes Trine , Høivik Hans , Karlsson Thomas , Munk Peter Scott , Radtke Maria , Risberg Knut , Rocke Jan , Solnør Leidulv , Stenehjem Aud-Eldrid , Tafjord Anne-Beathe , Asprusten Emil , Hagemeier Robert , Høye Kjetil , Selsås Hilde , Thorup Frode , Wium Cecilie , Pamugas Glenda , Panelo Araceli , Perez Ronald , Tanque Maribel , Tirador Louie , Villa Michael , Bautista Albert , Catindig Elizabeth , Manalo Carlo , Mirasol Roberto , Butrymowicz Patrycja , Ciechanowski Kazimierz , Cieslik Grazyna , Franek Edward , Gumprecht Janusz , Hoffmann Michal , Krzykowska Jolanta , Kurnatowska Ilona , Landa Katarzyna , Madrzejewski Adam , Madziarska Katarzyna , Mazur Stanislaw , Napora Piotr , Nowicki Michal , Ocicka-Kozakiewicz Anna , Rewerska Barbara , Rusicka Teresa , Ruxer Jan , Skokowska Ewa , Stankiewicz Andrzej , Stompor Tomasz , Tiuryn-Petrulewicz Agnieszka , Wasilewska Katarzyna , Wierusz-Wysocka Bogna , Wnetrzak-Michalska Renata , Jedynasty Krystyna , Sein Anand Izabela , Almeida Edgar , Ballesteros Rosa , Barreto Carlos , Beirao Idalina , Birne Rita , Esteves Cesar , Guia Jose , Heitor Susana , Marques Olinda , Melo Pedro , Nolasco Fernando , Pereira Amalia , Roque Cristina , Rosario Francisco , Silva Gil , Silva Ana , Teixeira e Costa Fernando , Vila Lobos Ana , Alves Ana Rita , Brandao Ilidio , Carvalho Rui , Coelho Joao , Lourenco Ana , Matos Pedro , Rosario Vanisa , Neves Joao Sergio , Cortes-Maisonet Gregorio , Roman-Miranda Amaury , Brito-Peguero Yudit , Colon-Vega Gildred , Albota Adrian , Bala Cornelia , Barbonta Hortensia , Caceaune Elena , Catrinoui Doina , Constantin Ciprian , Dumitrescu Adriana , Mindrescu Nicoleta , Mistode Cristina , Negrisanu Gabriela , Onaca Adriana , Paveliu Silvia , Pintilei Ella , Pop Lavinia , Popa Amorin , Popescu Alexandrina , Radulian Gabriela , Szilagyi Iosif , Turcu Liana , Vacaru Georgeta , Vlad Adrian , Filimon Adriana , Veresiu Ioan , Antsiferov Mikhail , Arkhipov Mikhail , Babkin Andrey , Barbarash Olga , Baranov Vitaliy , Chernyavskaya Elena , Demko Arkadiy , Dreval Alexander , Edin Anton , Ermakova Polina , Fadeev Valentin , Galyavich Albert , Gaysina Leyla , Gordeev Ivan , Ipatko Irina , Kalashnikova Marina , Khalimov Yuriy , Klimontov Vadim , Kobalava Zhanna , Kosmacheva Elena , Koziolova Natalya , Kvitkova Lyudmila , Levashov Sergey , Libis Roman , Marasaev Vyacheslav , Malykh Natalia , Martynenko Vladimir , Malyutina Sofya , Merai Imad , Mkrtumyan Ashot , Nechaeva Galina , Petunina Nina , Palyutin Shamil , Pimenov Leonid , Rechkova Elena , Rodionova Tatyana , Rymar Oksana , Sardinov Ruslan , Semenova Olga , Sherenkov Alexander , Solovev Oleg , Smolyarchuk Elena , Strongin Leonid , Ukhanova Olga , Verlan Nadezhda , Vorokhobina Natalya , Yakhontov Davyd , Yakushin Sergey , Zakharova Elena , Zalevskaya Alsu , Zanozina Olga , Zhdanova Elena , Zhukova Larisa , Zykova Tatyana , Argunova Yulia , Nikolaev Konstantin , Villevalde Svetlana , Sum Chee Fang , Suhail Sufi Muhummad , Tan Ru San , Vathsala Anantharaman , Wong Edmund , Bee Yong Mong , Babikova Jana , Buganova Ingrid , Dzupina Andrej , Ochodnicka Zuzana , Sosovec Dalibor , Spodniakova Denisa , Minarik Peter , Ahmed Fayzal , Amod Aslam , Bhana Sindeep , Distiller Larry , Jansen van Rensburg Dirkie , Joshi Mukesh , Joshi Shaifali , Lakha Deepak , Mitha Essack , Podgorski Gracjan , Ranjith Naresh , Rayner Brian , Rheeder Paul , Sarvan Mohamed , Seeber Mary , Siebert Heidi , Tayob Mohammed , Trokis Julien , Urbach Dorothea , van Zyl Louis , Jansen van Rensburg Dirkie , Choi Bum-Soon , Choi Moon Gi , Chung ChoonHee , Hwang YouCheol , Kim ChongHwa , Kim InJoo , Kim JaeHyeon , Kim SinGon , Kim SungGyun , Kim Tae Hee , Lee WooJe , Lee ByungWan , Lee Kang Wook , Oh Kook-Hwan , Oh Ji Eun , Oh Yun Kyu , Oh Dong-Jin , Park Junbeom , Shin Seok Joon , Sung Su-Ah , Yu Jae Myung , Chung HyeSoo , Huh Ji Hye , Kang JunGoo , Kim ChulSik , Kim HyeSoon , Kim NamHoon , Lim Soo , Cho Young Min , Young Park Cheol , Agraz Irene , Ampudia Francisco Javier , Bouarich Hanane , Calero Francesca , Castro Cristina , Cigarrán Guldris Secundino , Cruzado Garrit Josep , de Álvaro Fernando , Galcerán Josep , González Albarrán Olga , Hernández Jaras Julio , Ibernón Meritxell , Martínez Deben Francisco , Martínez Esteban Mª Dolores , Pascual Izuel José María , Martins Judith , Mediavilla Juan , Michán Alfredo , Santos Julio Pascual , Poch Esteban , Polaina Rusillo Manuel , Sánchez Juan Carlos , Santamaría Olmo Rafael , Segura de la Morena José Julián , Soto Alfonso , Troya Maribel , Cereto Castro Fernando , Gómez Fernández Pablo , Fuentes Sánchez Laura , González Moya Mercedes , Hernández Marrero Domingo , Piedrola Maroto Gonzalo , Redón Josep , Seron Daniel , Bruchfeld Annette , Curiac Dan , Eliasson Ken , Frank Malin , Guron Gregor , Hellberg Olof , Hellgren Margareta , Larnefeldt Hans , Lindholm Carl-Johan , Löndahl Magnus , Rein-Hedin Erik , Soveri Inga , Spaak Jonas , Tengmark Bengt-Olov , Lif-Tiberg Cornelia , Månflod Johan , Nguyen Han , Ackermann Daniel , Bilz Stefan , Burnier Michel , Forster Christian , Kalbermatter Stefan , Kistler Andreas , Pechère-Bertschi Antoinette , Schultes Bernd , Laimer Markus , Rudofsky Gottfried , Strey Christopher , Wuerzner Gregoire , Chang Chiz-Tzung , Hung Cheng-Chieh , Jiang Ju-Ying , Lee Chien-Te , Lin Shuei-Liong , Tarng Der-Cherng , Tu Shih-Te , Wu Mai-Szu , Wu Ming-Ju , Chuang Lee-Ming , Deerochanawong Chaicharn , Kitiyakara Chagriya , Ophascharoensuk Vuddhidej , Pongchaiyakul Chatlert , Satirapoj Bancha , Kosachunhanan Natapong , Sritara Piyamitr , Eren Necmi , Gul Ibrahim , Gulel Okan , Kocyigit Ismail , Kumbasar Abdulbaki , Sahin Idris , Sari Ramazan , Sayin Burak , Tavli Talat , Ustundag Sedat , Yenicerioglu Yavuz , Badak Ozer , Cayli Murat , Oguz Aytekin , Ozdogan Oner , Sari Ibrahim , Temizhan Ahmet , Tigen Mustafa , Turk Ugur , Yilmaz Huseyin , Yilmaz Mehmet , Bondarets Iryna , Botsyurko Volodymyr , Chernikova Viktoriia , Donets Oleksandra , Fushtey Ivan , Grachova Mariia , Isayeva Anna , Kogut Dmytro , Komisarenko Julia , Kravchun Nonna , Malyar Kateryna , Mankovsky Borys , Martynyuk Liliya , Maslyanko Vitaliy , Myshanych Halyna , Pererva Larysa , Pertseva Nataliia , Serhiyenko Oleksandr , Smirnov Ivan , Sokolova Liubov , Stryzhak Vasyl , Vlasenko Maryna , Isayeva Ganna , Larin Oleksandr , AbouSaleh Ahmad , Barratt Jonathan , Dang Cuong , Kahal Hassan , Kirk Adam , Kilvert Anne , Kon Sui Phi , McCafferty Kieran , Patel Dipesh , Rice Sam , Vijayaraman Arutchelvam , Wong Yuk-ki , Gibson Martin , Wahba Mona , Zaidi Reza , Bilous Rudy , Johnson Andrew , Kalathil Dhanya , Kilvert Anne , Kyriakidou Christina , Mathew Amit , Mukhtar Rasha , Munsoor Imrozia , Poterajlo Anton , Swift Pauline , Acosta Idalia , Adams Atoya , Adler Sharon , Ajani Dilawar , Ali Slamat , Alicic Radica , Al-Karadsheh Amer , Alla Sreedhara , Andrawis D. Allison Nabil , Arif Ahmed , Awad Ahmed , Azizad Masoud , Bahrami Michael , Bansal Shweta , Barag Steven , Barakzoy Ahmad , Barney Mark , Barzilay Joshua , Bashir Khalid , Bautista Jose , Beddhu Srinivasan , Belo Diogo , Benjamin Sabrina , Berenji Ramin , Bhargava Anuj , Birriel Jose , Brietzke Stephen , Brosius Frank , Brusco Osvaldo , Burgner Anna , Busch Robert , Canadas Rafael , Caramori Maria , Cardona Jose , Case Christopher , Cruz Humberto , Dandillaya Ramprasad , Dawoud Dalia , Din Zia , Dixon Bradley , Doshi Ankur , Drakakis James , El Shahawy Mahfouz , El-Meanawy Ashraf , El-Shahawy Mohammed , Evans John , Fadda George , Farooq Umar , Fernando Roland , Fink Raymond , First Brian , Fitz-Patrick David , Flack John , Fluck Patrick , Fogelfeld Leon , Fonseca Vivian , Frias Juan , Galphin Claude , Garcia-Mayol Luis , Goldstein Gary , Gonzalez Edgar , Gonzalez-Abreu Francisco , Gore Ashwini , Grant David , Habwe Violet , Hamilton Maxine , Hammoud Jamal , Handelsman Stuart , Hartman Israel , Heigerick Glenn , Henry Andrew , Hernandez German , Hernandez-Cassis Carlos , Herrera Carlos , Hertel Joachim , Huang Wenyu , Iglesias Rogelio , Iranmanesh Ali , Jackson Timothy , Jain Mahendra , Jamerson Kenneth , Johnson Karen , Judd Eric , Kaplan Joshua , Kayali Zeid , Khan Bobby , Khan Muhammad , Kharait Sourabh , Kirkman M. Sue , Kopyt Nelson , Kotzker Wayne , Kovesdy Csaba , Kreit Camil , Krishna Arvind , Kronfli Saeed , Lee Keung , LeJeune Derek , Lemus Brenda , Leon-Forero Carlos , Linfert Douglas , Lora Henry , Lurie Alexander , Maddukuri Geetha , Magno Alexander , Maletz Louis , Mandayam Sreedhar , Markell Mariana , Mayfield Ronald , Mbogua Caroline , McMullen Dierdre , Meisner Carl , Minton Stephen , Mocherla Bharat , Mohandas Rajesh , Montero Manuel , Moustafa Moustafa , Nadkarni Salil , Nakhle Samer , Navarro Jesus , Neyra Nilda , Nica Romanita , Nicol Philip , Norwood Paul , Numrungroad Visal , O’Donovan Richard , Odugbesan A. , Paoli-Bruno Jorge , Parikh Samir , Patel Rakesh , Peixoto Aldo , Pergola Pablo , Perlman Alan , Pettis Karlton , Pisoni Roberto , Ponduchi Mirela , Posada Jorge , Prabhakar Sharma , Radhakrishnan Jai , Rahman Mahboob , Raina Rupesh , Rastogi Anjay , Reisin Efrain , Rendell Marc , Robertson David , Rocco Michael , Romeu Hugo , Rosas Sylvia , Rosenfeld Jack , Ross Dennis , Rothman Jeffrey , Rudolph Lance , Ruhullah Yusuf , Ruoff Gary , Ryu Jeffrey , Sahani Mandeep , Sam Ramin , Samuels Garfield , Sanchez William , Santos Vladimir , Satko Scott , Saxena Sanjeev , Scott David , Seco Gilberto , Seek Melvin , Serota Harvey , Shafi Tariq , Shahid Nauman , Shanik Michael , Sharma Santosh , Sinha Arjun , Smelser James , Smith Mark , Soe Kyaw , Solomon Richard , Soroka Eugene , Soufer Joseph , Spinowitz Bruce , Spry Leslie , Suarez Rosa , Subramanian Bala , Szerlip Harold , Tamirisa Aparna , Thomson Stephen , Tran Tuan-Huy , Treger Richard , Trullenque Gretel , Turk Thomas , Umpierrez Guillermo , Urbach Daniel , Valdes Martin , Valika Shujauddin , Vega Damaris , Weissman Peter , Whaley-Connell Adam , Winston Jonathan , Wise Jonathan , Wynne Alan , Zeig Steven , Abdel-Rahman Emaad , Abreu Edel , Awad Alaa , Bahri Nader , Bertsch John , Bleich David , Bornfreund Jonathan , Brar Harjeet , Brian Susan , Brinson Cynthia , Bruschetta Humberto , Carpio Jose , Cohen Steven , Cosby John , Dhanireddy Soni , Diaz Jorge , Dunn Fredrick , Eppanapally Sabitha , Fayad Joseph , Goel Archana , Govindaraju Kanakadurga , Halpern Stephen , Jones Audrey , Kaye William , Knight Herbert , Koch Stanley , Kohli Nandini , Lastra Guido , Lerman Sam , Loredo Jorge , Lovre Dragana , Mandviwala Mustafa , Martin Earl , Meyer Jill , Murray John , Oliver David , Oparil Suzanne , Penabad Jesus , Pereira Isabel , Popeil Larry , Quesada Gonzalo , Ramanathan Kodangudi , Ramos-Gonez Luis , Rastegar Mandana , Rastogi Padmashri , Rondon Juan , Roy-Chaudhury Prabir , Smith David , Williamson Don , Womack Catherine , Yamout Hala , Yuryev Michael , Chu Phuong , Hoang Lam Van , Khanh Tran , Nga Nguyen Thi Phi , Son Pham Nguyen , Tran Lan Phuong , Le Thuy Khuong , Nguyen Boi Ngoc , Nguyen Thao , Nui Nguyen Minh , Nam Tran Quang , Tran Kim Chi 
Published: August 2022

OBJECTIVE
Finerenone reduced the risk of kidney and cardiovascular events in people with chronic kidney disease (CKD) and type 2 diabetes in the FIDELIO-DKD and FIGARO-DKD phase 3 studies. Effects of finerenone on outcomes in patients taking sodium–glucose cotransporter 2 inhibitors (SGLT2is) were evaluated in a prespecified pooled analysis of these studies.

RESEARCH DESIGN AND METHODS
Patients with type 2 diabetes and urine albumin-to-creatinine ratio (UACR) ≥30 to ≤5,000 mg/g and estimated glomerular filtration rate (eGFR) ≥25 mL/min/1.73 m2 were randomly assigned to finerenone or placebo; SGLT2is were permitted at any time. Outcomes included cardiovascular composite (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure) and kidney composite (kidney failure, sustained ≥57% eGFR decline, or renal death) end points, changes in UACR and eGFR, and safety outcomes.

RESULTS
Among 13,026 patients, 877 (6.7%) received an SGLT2i at baseline and 1,113 (8.5%) initiated one during the trial. For the cardiovascular composite, the hazard ratios (HRs) were 0.87 (95% CI 0.79–0.96) without SGLT2i and 0.67 (95% CI 0.42–1.07) with SGLT2i. For the kidney composite, the HRs were 0.80 (95% CI 0.69–0.92) without SGLT2i and 0.42 (95% CI 0.16–1.08) with SGLT2i. Baseline SGLT2i use did not affect risk reduction for the cardiovascular or kidney composites with finerenone (Pinteraction = 0.46 and 0.29, respectively); neither did SGLT2i use concomitant with study treatment.

CONCLUSIONS
Benefits of finerenone compared with placebo on cardiorenal outcomes in patients with CKD and type 2 diabetes were observed irrespective of SGLT2i use.