bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prognostic role of liver volumetry in Fontan patients
Authors: Najashi Khalid Al , Najashi Nejoud Al , Ahmed Taghreed , Abdelnaeem Rayan , Alolit Sultan , Zuaybir Amani Al , Atiyah Merna , Trout Andrew T. , Alsaied Tarek , Veldtman Gruschen R. 
Published: October 2022

AbstractBackground and hypotheses:High venous pressures and associated hepatic congestion are important drivers for Fontan-associated liver disease. The prognostic significance of hepatomegaly as a marker of congestion however is not well defined and is further explored in this research study.Methods:Fontan patients who have had liver ultrasound scans were identified from the Prince Sultan Cardiac Centre Fontan Database and had their anatomic, surgical, clinical histories abstracted from the electronic medical records following institutional ethics approval. Liver volumes were determined retrospectively from reviewing individual US images, and these, divided into tertiles, were analysed in the context of the predefined endpoints of (i) Primary – death or heart or liver transplantation, or (ii) Secondary – combined endpoint of death, transplantation, arrhythmia, or protein-losing enteropathy.Results:Mean indexed liver volumes for the entire cohort (n = 199) were 1065.1 ± 312.1 ml/m2, range 387 to 2071 ml/m2. Patients with the largest liver volumes (highest tertile) were less likely to have a functioning fenestration compared to those in the lowest tertile 44% versus 56% p = 0.016 and experienced the highest burden of mortality and heart or heart–liver transplantation, p = 0.016, and were more likely to reach the composite endpoint of death, protein-losing enteropathy, arrhythmia, or transplantation, p = 0.010. Liver volumes had an overall predictive accuracy for the combined outcome of 61% (CI 53%, 67%, p = 0.009).Conclusions:Liver volumetry may serve as a potentially important congestion biomarker for adverse outcomes after the Fontan operation.
Early outcomes of the treatment of aortic coarctation with BeGraft aortic stent in children and young adults
Authors: Kavurt Ahmet V. , Gürsu Hazım A. , Kaş Gökçe , Özdemiroğlu Nevin , Bağrul Denizhan , Gül Ayşe E. K. , Ece İbrahim , Çetin İbrahim İ 
Published: October 2022

AbstractWe report our experience and early outcomes of using the BeGraft aortic stent in children, adolescents, and young adults. BeGraft aortic stent (Bentley InnoMed, Hechingen, Germany) requires a smaller long sheath compared to other covered stents, and it has a low profile and adequate radial power. With these features, it can overcome some limitations in the treatment of coarctation, especially in children. This is a single centre retrospective analysis of 11 implanted BeGraft aortic stents in coarctation of the aorta between July 2020 and November 2021. The eleven stents were successfully implanted in 11 patients (10 males). The median age of the patients was 13.7 years (interquartile range 12–16 years), and the median weight was 43 kg (interquartile range 35–62 kg). In five patients, after the stents were opened completely by the first balloon, they were exchanged with a Z-MED II™ balloon, 1–3 mm larger in diameter, and the stents were redilated. The median catheter-derived systolic peak-to-peak pressure gradient was 23 mm Hg (interquartile range 16–37 mmHg) before the procedure and 3 mm Hg (interquartile range 1–5 mm Hg) after the procedure. Except for the partial femoral artery thrombosis in two patients, no other procedural complications were observed in our study. The median follow-up duration was 5 months (interquartile range 2–12 months). During follow-up, only one patient (9%) had stent narrowing that required dilation. Our initial results and short-term follow-up showed that the BeGraft aortic stent implantation and redilation can be performed effectively, safely, and successfully in the treatment of coarctation of the aorta.
Effect of eTansiyon smartphone application on hypertension control
Authors: Yilmaz Emre , Uzuner Arzu , Bajgora Mensur , Dogan Buket , Altikardes Zehra A. , Kavakli Geris Burçin , Akdeniz Esra 
Published: October 2022

Abstract

Aim:
To investigate the effectiveness of eTansiyon smartphone application in blood pressure control in patients with hypertension.

Background:
Global prevalence of hypertension and the burden of chronic illness care, especially in primary care, are increasing in world. We have developed eTansiyon to ensure the continuity of patient-physician relationship, so it may help to improve the lifestyle of patients with hypertension, increase their adherence to treatment and achieve the target blood pressure.

Methods:
This study was a non-randomized controlled study. The sample was selected by random sampling method among the patients registered in 6 Family Health Units (FHUs). Randomization was performed at the FHU level; the units were randomized to 4 control group (CG) and 2 intervention group (IG), so that randomization in this study was 2:1. Both groups were followed up for at least four months. In addition to CG, IG were provided to use eTansiyon. Obtained data were analysed to evaluate differences between groups at the beginning and end of the study, intra-group changes after follow-up and interaction between groups and follow-up period.

Findings:
The study was performed with 124 patients in CG and 61 patients in IG. At the end of the study, the average systolic blood pressure/diastolic blood pressure (SBP/DBP) of office and home was significantly lower in IG compared to CG (P < 0.001, MD 9.5 mmHg; P = 0.007, MD 3.8 mmHg; P < 0.001, MD 10.6 mmHg; P < 0.001, MD 4.8 mmHg, respectively), and it was found that the proportion of people with target blood pressure in IG was significantly higher than CG (P < 0.001, 49.2%(n = 30) and 22.6%(n = 28), respectively). Repeated measures ANOVA and generalized estimating equations results showed that follow-up period and interaction between groups were significant in terms of office and home SBP/DBP and target blood pressure level during follow-up period (P < 0.001, P < 0.001, P < 0.001, P < 0.001, P < 0.024, respectively).
Brief review about history of astrobiology
Authors: Nascimento-Dias Bruno Leonardo do , Martinez-Frias Jesús 
Published: October 2022

AbstractThe main idea of this work is to develop a chronological and descriptive historical review in a summarized form about content on astrobiology, which is a research area considered as an emerging science. This is exploratory research that was developed from document review from scientific articles and books, that related to the themes of astrobiology, exobiology and the search for life outside the Earth were used. Based on the research developed, it was possible to collect data related to the vision of other worlds beyond Earth from the ancient Greeks to the present day. Finally, it was possible to conclude that although astrobiology is a recent area of scientific research, the concept and search for life outside the Earth already existed long before the development of modern science.
Risk and uncertainty of plastic mulch adoption in raspberry production systems
Authors: Madrid B. , Goldberger J. R. , Miles C. A. , DeVetter L. W. 
Published: October 2022

AbstractAgriculture plays a central role in providing food security and essential goods globally. Producers must consider and manage risk to ensure that the production system and its associated individuals are capable of enduring unexpected and disruptive events. Analyzing the different types of risk and accompanying uncertainties that growers experience can be essential to better reflect and understand the realities of their circumstances, but these concepts are not always accounted for in the adoption process. Drawing on the importance of risk and uncertainty, this study aims to assess the different types of risk and uncertainties involved in the risk decision-making process of the processed raspberry industry, where plastic mulch is a new production technique. Semi-structured interviews were conducted with participants involved in the use, research, outreach, manufacturing, and distribution of plastic mulch, specifically polyethylene (PE) mulch and soil-biodegradable mulch (BDM). Findings indicate that risk can be present in various forms including production, price, and hidden risks, with production and price risks being the most significant to all participants. When accounting for overall risk, PE mulch was considered riskier to industry representatives but less risky to growers and most research and outreach specialists. BDM was considered risky due to the uncertainties about durability, degradability, and the unknown impacts on the environment if BDM fragments do not degrade readily. The application of PE mulch and/or BDM can be beneficial for the raspberry production systems but will require time for additional research and effort to disseminate information to a wider agricultural audience.
An Analysis of Magnetosphere‐Ionosphere Coupling That Is Independent of Inertial Reference Frame
Authors: Mannucci Anthony J. , McGranaghan Ryan , Meng Xing , Verkhoglyadova Olga P. 
Published: October 2022

AbstractThis paper analyses magnetosphere‐ionosphere (M‐I) coupling from a perspective that is independent of inertial reference frame, and delineates how physical theories of M‐I coupling are affected by the principle of relativity. For the first time in the context of M‐I coupling, we discuss the literature from the 1970s on how the low‐velocity limit of the theory of special relativity is applied to electrodynamics. In most M‐I coupling theories, a particular low‐velocity limit applies, known as the “magnetic limit.” Two important consequences of this literature are: (a) significant displacement currents in Maxwell's equations break the Galilean invariance of the equations and (b) magnetic fields are not generated by currents created by a net charge density in motion. We show how reference frame‐independent descriptions of M‐I coupling require that ion‐neutral relative velocities and ion‐neutral collisions are key drivers of the physics. Currents are independent of reference frame whereas electric fields depend on reference frame. Starting with the same momentum equations that are typically used to derive Ohm's law, it is possible to express the perpendicular ionospheric current as depending on collisions between ions and neutrals, and electrons and neutrals, without reference to electric fields. Ignoring the relative motion between ions and neutrals results in errors exceeding 100% for estimates of high latitude Joule heating during significant geomagnetic storms, when ion‐neutral velocity differences are largest near the initiation of large‐scale ion convection.
High‐Frequency Electrostatic Waves Modulated by Whistler Waves Behind Dipolarization Front
Authors: Chen Z. Z. , Yu J. , Wang J. , He Z. G. , Liu N. G. , Cui J. , Cao J. B. 
Published: October 2022

AbstractBoth the whistler waves and high‐frequency electrostatic waves (HFEWs), playing significant roles in energy conversion, have been widely studied behind dipolarization fronts (DFs). Nevertheless, interactions between them have been so far elusive. Utilizing high‐resolution MMS data, we present two cases that HFEWs were modulated by whistler waves behind a DF. The HFEWs with frequency at fce ∼ fpe, propagating along the ambient magnetic field, were detected near δE// minimum (maximum) of parallel‐propagating (antiparallel‐propagating) whistler waves. The amplitudes of the HFEWs are comparable to that of the whistler waves, while their energy densities are two orders of magnitude lower than that of the whistler waves. The analysis indicates that the whistler waves were locally excited by anisotropic electron distributions and the HFEWs were excited by electron beams produced by the whistler waves via Landau resonance. Our study advances the understanding of wave‐wave interactions and cross‐scale processes in space plasmas.
Imaging the Volcanic Structures Beneath Gran Canaria Island Using New Gravity Data
Authors: Montesinos F. G. , Arnoso J. , Gómez‐Ortiz D. , Benavent M. , Blanco‐Montenegro I. , Vélez E. , Martín‐Crespo T. , Gorbatikov A. V. , Stepanova M. Y. 
Published: October 2022

AbstractFrom a new gravity data set that covers homogeneously the whole surface of Gran Canaria (Canary Islands, Spain) and marine gravity data in the nearest offshore, we have obtained a Bouguer anomaly gravity map of the island which improves the previous ones. Using these gravity anomalies, we have applied a gravity inversion approach to investigate the structures beneath the surface of Gran Canaria Island and derive a 3D gravity sources model. The geometry of structures with anomalous density values is constrained up to a depth of approximately 20,000 m below the sea level. The interpretation of the density model identified structures related to the different volcanic stages of Gran Canaria. Several deep‐rooted high‐density structures represent the intrusive bodies emplaced in the early formation of Gran Canaria and the magma plumbing system of the Miocene volcanic edifices. A low‐density body in the center of the island may be associated with the syenitic core of the felsic central volcanic edifice (Tejeda Caldera). Shallow low‐density structures identified fractures which acted as feeder dikes of monogenetic volcanoes during the rejuvenated stage. Finally, the NW‐SE rift, which is the most important volcano‐tectonic structure of Gran Canaria, has a characteristic gravimetric signature and represents a long‐lived extensional fracture zone that has controlled the volcanic activity at least since the Miocene.
Nappe Imbrication Within the Phyllite‐Quartzite Unit of West Crete: Implications for Sustained High‐Pressure Metamorphism in the Hellenide Subduction Orogen, Greece
Authors: Ring Uwe , Fassoulas Charalampos , Uysal I. Tonguç , Bolhar Robert , Tong Kui , Todd Andrew 
Published: October 2022

AbstractWe report four K‐Ar fault‐gouge and eight U‐Pb calcite ages from the high‐pressure Phyllite‐Quartzite Unit (PQ) and the overlying, strongly thinned non‐high‐pressure Tripolitza and Pindos units of western Crete, Greece. We relate consistent 26–21 Ma fault‐gouge ages to a discrete top‐to‐the‐S, brittle‐ductile, contractional shear zone (Intra‐PQ Thrust) that formed during high‐pressure conditions within the Phyllite‐Quartzite Unit. The Intra‐PQ Thrust separates the Phyllite‐Quartzite Unit into an upper and a lower unit and is associated with gypsum deposits and high finite strain. Below the Intra‐PQ Thrust, U‐Pb calcite ages between about 16 and 13 Ma are also associated with top‐to‐the‐S kinematic indicators and, in part, developed during aragonite stability. The brittle‐ductile contact zone to the overlying Tripolitza and Pindos units yielded U‐Pb calcite ages of 13 to 12 Ma. Our data imply that the upper Phyllite‐Quartzite Unit underwent high‐pressure metamorphism at the commonly envisaged time of 24–21 Ma. However, the lower Phyllite‐Quartzite Unit started to be underthrust at 26–21 Ma and was high‐pressure metamorphosed at 16–13 Ma, as suggested by the U‐Pb calcite ages of aragonite‐bearing samples and published zircon fission track ages. We discuss a tectonic model of successive underthrusting, high‐pressure metamorphism and subsequent exhumation of both Phyllite‐Quartzite units in extrusion wedges until 12–11 Ma, after which Crete underwent crustal extension. Our work suggests that there might be more than one Cretan Detachment. It also has implications for sustained underthrusting and exhumation of continental crust in subduction zones.
Metabolic genes on conjugative plasmids are highly prevalent in Escherichia coli and can protect against antibiotic treatment
Authors: Palomino Alana , Gewurz Danya , DeVine Lela , Zajmi Ujana , Moralez Jenifer , Abu-Rumman Fatima , Smith Robert P , Lopatkin Allison J 
Published: October 2022

Abstract
Conjugative plasmids often encode antibiotic resistance genes that provide selective advantages to their bacterial hosts during antibiotic treatment. Previous studies have predominantly considered these established genes as the primary benefit of antibiotic-mediated plasmid dissemination. However, many genes involved in cellular metabolic processes may also protect against antibiotic treatment and provide selective advantages. Despite the diversity of such metabolic genes and their potential ecological impact, their plasmid-borne prevalence, co-occurrence with canonical antibiotic resistance genes, and phenotypic effects remain widely understudied. To address this gap, we focused on Escherichia coli, which can often act as a pathogen, and is known to spread antibiotic resistance genes via conjugation. We characterized the presence of metabolic genes on 1,775 transferrable plasmids and compared their distribution to that of known antibiotic resistance genes. We found high abundance of genes involved in cellular metabolism and stress response. Several of these genes demonstrated statistically significant associations or disassociations with known antibiotic resistance genes at the strain level, indicating that each gene type may impact the spread of the other across hosts. Indeed, in vitro characterization of 13 statistically relevant metabolic genes confirmed that their phenotypic impact on antibiotic susceptibility was largely consistent with in situ relationships. These results emphasize the ecological importance of metabolic genes on conjugal plasmids, and that selection dynamics of E. coli pathogens arises as a complex consequence of both canonical mechanisms and their interactions with metabolic pathways.
Insights into skeletal stem cells
Authors: Li Qiwen , Xu Ruoshi , Lei Kexin , Yuan Quan 
Published: October 2022

AbstractThe tissue-resident skeletal stem cells (SSCs), which are self-renewal and multipotent, continuously provide cells (including chondrocytes, bone cells, marrow adipocytes, and stromal cells) for the development and homeostasis of the skeletal system. In recent decade, utilizing fluorescence-activated cell sorting, lineage tracing, and single-cell sequencing, studies have identified various types of SSCs, plotted the lineage commitment trajectory, and partially revealed their properties under physiological and pathological conditions. In this review, we retrospect to SSCs identification and functional studies. We discuss the principles and approaches to identify bona fide SSCs, highlighting pioneering findings that plot the lineage atlas of SSCs. The roles of SSCs and progenitors in long bone, craniofacial tissues, and periosteum are systematically discussed. We further focus on disputes and challenges in SSC research.
The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans
Authors: Beaudoin-Chabot Caroline , Wang Lei , Celik Cenk , Abdul Khalid Aishah Tul-Firdaus , Thalappilly Subhash , Xu Shiyi , Koh Jhee Hong , Lim Venus Wen Xuan , Low Ann Don , Thibault Guillaume 
Published: October 2022

AbstractMetabolic diseases often share common traits, including accumulation of unfolded proteins in the endoplasmic reticulum (ER). Upon ER stress, the unfolded protein response (UPR) is activated to limit cellular damage which weakens with age. Here, we show that Caenorhabditis elegans fed a bacterial diet supplemented high glucose at day 5 of adulthood (HGD-5) extends their lifespan, whereas exposed at day 1 (HGD-1) experience shortened longevity. We observed a metabolic shift only in HGD-1, while glucose and infertility synergistically prolonged the lifespan of HGD-5, independently of DAF-16. Notably, we identified that UPR stress sensors ATF-6 and PEK-1 contributed to the longevity of HGD-5 worms, while ire-1 ablation drastically increased HGD-1 lifespan. Together, we postulate that HGD activates the otherwise quiescent UPR in aged worms to overcome ageing-related stress and restore ER homeostasis. In contrast, young animals subjected to HGD provokes unresolved ER stress, conversely leading to a detrimental stress response.
Immature olfactory sensory neurons provide behaviourally relevant sensory input to the olfactory bulb
Authors: Huang Jane S. , Kunkhyen Tenzin , Rangel Alexander N. , Brechbill Taryn R. , Gregory Jordan D. , Winson-Bushby Emily D. , Liu Beichen , Avon Jonathan T. , Muggleton Ryan J. , Cheetham Claire E. J. 
Published: October 2022

AbstractPostnatal neurogenesis provides an opportunity to understand how newborn neurons integrate into circuits to restore function. Newborn olfactory sensory neurons (OSNs) wire into highly organized olfactory bulb (OB) circuits throughout life, enabling lifelong plasticity and regeneration. Immature OSNs form functional synapses capable of evoking firing in OB projection neurons but what contribution, if any, they make to odor processing is unknown. Here, we show that immature OSNs provide odor input to the mouse OB, where they form monosynaptic connections with excitatory neurons. Importantly, immature OSNs respond as selectively to odorants as mature OSNs and exhibit graded responses across a wider range of odorant concentrations than mature OSNs, suggesting that immature and mature OSNs provide distinct odor input streams. Furthermore, mice can successfully perform odor detection and discrimination tasks using sensory input from immature OSNs alone. Together, our findings suggest that immature OSNs play a previously unappreciated role in olfactory-guided behavior.
Retrospective real-life study on preoperative imaging for minimally invasive parathyroidectomy in primary hyperparathyroidism
Authors: Bijnens Jacqueline , Van den Bruel Annick , Vander Poorten Vincent , Goethals Ingeborg , Van Schandevyl Steven , Dick Catherine , De Geeter Frank 
Published: October 2022

AbstractThe objective of this study was to retrospectively evaluate preoperative imaging modalities for localization of parathyroid adenomas with a view to enable minimally invasive parathyroidectomy and in particular, to consider the contribution of 18F-fluorocholine-PET/CT. 104 patients with primary hyperparathyroidism, who underwent parathyroid surgery in a single centre during a 6-year period were included. Of these, 103 underwent ultrasound, 97 99mTc-Pertechnetate/SestaMIBI-SPECT, 20 MRI and 30 18F-fluorocholine-PET/CT. Based on surgical findings, sensitivities and specificities for correct lateralisation in orthotopic locations were: for ultrasound 0.75 (0.65–0.83) and 0.89 (0.81–0.94), for 99mTc-MIBI-SPECT 0.57 (0.46–0.67) and 0.97 (0.91–0.99), for MRI 0.60 (0.36–0.81) and 0.83 (0.59–0.96) and for 18F-fluorocholine-PET/CT 0.90 (0.73–0.98) and 0.90 (0.73–0.98). Correctly lateralized adenomas were significantly larger than those not found with ultrasound (p = 0.03) and SPECT (p = 0.002). Pre-operative PTH-levels were higher in single adenomas detected by scintigraphy than in those not (p = 0.02). 64 patients could be treated with a minimally invasive procedure. Cure after parathyroidectomy was obtained in 94% of patients. 18F-Fluorocholine-PET/CT could be shown to be a highly accurate modality to localize parathyroid adenomas preoperatively, obviating the need for total exploration in the majority of patients in whom ultrasound and scintigraphic results are discordant or both negative.