bluuebunny/crossref_metadata_2025_split huggingface dataset:
The utility of near infrared autofluorescence imaging for detecting small bowel carcinoid tumors in comparison to DOTATATE PET: A pilot study
Authors: Berber Eren , Ergun Onuralp , Avci Seyma , Isiktas Gizem , Osman Mohammed , Mahajan Paresh 
Published: August 2022

AbstractBackgroundSmall bowel carcinoid (SBC) primary tumors can be multifocal in 40%–55% of patients and challenging to detect. Near infrared autofluorescence (NIRAF) is used for detection of parathyroid glands. It is unknown if this technology can be used to identify SBCs and how it would compare with current imaging modalities.MethodsThis was a prospective institutional review board‐approved pilot study of three patients undergoing resection of SBCs. NIRAF was used to image SBCs and mesenteric lymph nodes intraoperatively and at back table. Findings were compared with preoperative imaging, surgical exploration and pathology. Statistics were performed using Mann–Whitney U test.ResultsEleven SBCs and 12 mesenteric lymph nodes were analyzed. All SBCs had a brighter focal autofluorescence (AF) signal compared to background. Normalized pixel intensity of SBCs was 2.2 (0.7) and normal small bowel 1.4 (0.6) (p < 0.0001). NIRAF was less accurate in detecting occult lymph node metastasis, but was superior to DOTATATE PET for detecting SBCs in two of three patients.ConclusionsThis preliminary report suggests that SBCs exhibit distinctly bright AF signals on NIRAF to create a contrast distinction from normal small bowel. This technology may have a utility as an adjunctive tool for intraoperative detection of occult SBCs.
The impact of COVID‐19 on presentation and diagnosis of head and neck squamous cell carcinoma
Authors: Crossley Jason R. , Nelson Lacey L. , VanDolah Hunter , Davidson Bruce J. , Maxwell Jessica H. 
Published: August 2022

AbstractObjectiveTo analyze how the COVID‐19 pandemic has influenced trends in head and neck squamous cell carcinoma (HNSCC) presentation and diagnosis—including referral patterns, stage at presentation, and time to diagnosis—over a longitudinal time course.SettingMulticenter tertiary care academic institution.MethodsA retrospective review of patients with HNSCC presenting between January 1, 2019 and December 31, 2020 was performed. Patients were stratified into pre‐COVID and COVID cohorts based upon presentation date either before or after the COVID pandemic was declared a national emergency. Data was collected on demographics, referral site, symptoms, tumor characteristics, and time to diagnosis.ResultsOf 203 patients with HNSCC identified, 77.3% (157/203) were in the pre‐COVID cohort and 22.7% (46/203) were in the COVID cohort. Patients in the COVID cohort were more likely to present through inpatient or ER consultation (26% vs. 11%) than outpatient setting. There was a greater than 50% decrease in new tumor board case presentations per month in the COVID cohort (4.8) relative to the pre‐COVID (10.9) cohort. Cancer stage at presentation was similar between cohorts. Time from presentation to diagnosis was similar between the cohorts at approximately 30 days.ConclusionsThese results suggest that patients presenting during the COVID pandemic may have unique referral patterns. A significant decrease in tumor board presentations was noted, which may contribute to more delayed presentations that have yet to be observed. Further investigation with a larger sample size is warranted.Lay SummaryThe COVID‐19 pandemic may have changed where and how patients with head and neck cancer initially seek care. We found that patients with newly diagnosed head and neck cancer more often were initially seen in urgent settings than before the pandemic.Level of Evidence3
Polarized Photoluminescence Enhancement of Monolayer MoS2 Coupled with Plasmonic Salisbury‐Type Absorber
Authors: Li Wei , Xin Ming , Lan Wenze , Bai Qinghu , Du Shuo , Wang Gang , Liu Baoli , Gu Changzhi 
Published: August 2022

AbstractThe plasmon‐mediated manipulation of light–matter interaction in 2D atomically transition‐metal dichalcogenides (TMDs) critically depends on the design of plasmonic nanostructures to achieve the maximum optical field in TMDs. Here, a metal–isolator–metal Salisbury‐type perfect absorber is fabricated to serve as a generator of the localized surface plasmons. The significant photoluminescence (PL) enhancement up to 60‐fold is observed experimentally in the monolayer MoS2 on the top of this gold plasmonic hybrid nanostructures. Furthermore, the PL linear polarization can approach ≈60% around the peak of exciton emission and is independent on the polarization of the excitation laser. This Salisbury‐type plasmon–exciton hybrid system paves a new way to develop optoelectronic devices based on TMDs.
Metabolite Pattern Derived from Lactiplantibacillus plantarum—Fermented Rye Foods and In Vitro Gut Fermentation Synergistically Inhibits Bacterial Growth
Authors: Koistinen Ville M. , Hedberg Maria , Shi Lin , Johansson Anders , Savolainen Otto , Lehtonen Marko , Aura Anna‐Marja , Hanhineva Kati , Landberg Rikard 
Published: August 2022

ScopeFermentation improves many food characteristics using microbes, such as lactic acid bacteria (LAB). Recent studies suggest fermentation may also enhance the health properties, but mechanistic evidence is lacking. The study aims to identify a metabolite pattern reproducibly produced during sourdough and in vitro colonic fermentation of various whole‐grain rye products and how it affects the growth of bacterial species of potential importance to health and disease.Methods and resultsThe study uses Lactiplantibacillus plantarum DSMZ 13890 strain, previously shown to favor rye as its substrate. Using LC‐MS metabolomics, the study finds seven microbial metabolites commonly produced during the fermentations, including dihydroferulic acid, dihydrocaffeic acid, and five amino acid metabolites, and stronger inhibition is achieved when exposing the bacteria to a mixture of the metabolites in vitro compared to individual compound exposures.ConclusionThe study suggests that metabolites produced by LAB may synergistically modulate the local microbial ecology, such as in the gut. This could provide new hypotheses on how fermented foods influence human health via diet–microbiota interactions.
Moisture sensitive composite fiber based on agarose gel surface modification
Authors: Zhou Jun , Guo Jiachen , Chang Min , Chen Zhixin , Zhao Dong , Jia Bo 
Published: August 2022

AbstractA new moisture‐sensitive composite fiber has been reported. A 12‐μm‐diameter single‐mode tapered fiber is modified with a thickness of 10‐mm‐length agarose layer in the evanescent field of the tapered fiber. The application of agarose gel makes the composite fibers with lower temperature crosstalk. The average temperature crosstalk of the sensor is only 0.06 dB/%°C in the range of 40–70°C. Moreover, the thinner diameter of the composite fiber is designed to improve the time response, and the light intensity changes controlled in a smaller sensing area significantly increased the sensitivity of the sensor. The relative humidity (RH) sensitivity of the sensor is up to 0.78 dB/%RH in the sensing range. To the best of our knowledge, the performance of the fiber is effectively improved from the previous report. Due to the excellent indicators, the design of the proposed composite fiber makes it useful for highly sensitive RH sensing applications in a wide temperature environment.
Benchmarking community/primary care musculoskeletal services: A narrative review and recommendation
Authors: Burgess Roanna , Lewis Martyn , Hill Jonathan C. 
Published: August 2022

AbstractIntroductionHigh quality data on service performance is essential in healthcare to evidence efficacy, efficiency, and value. There remains a paucity of publicly reported data in community and primary care musculoskeletal (MSK) services. There is also a lack of guidance on which metrics MSK services should be collecting and reporting, and how this data could be used to directly improve patient outcomes, experiences, and value.MethodA narrative review of the evidence around benchmarking MSK services was undertaken with a focus on how to develop routine data collection within community/primary care settings, and how to develop benchmarking capabilities for the future, looking towards a national MSK audit. This evidence was triangulated with the findings from recent MSK data studies undertaken by the authors and emerging UK policy and guidance in this area.RecommendationsTo enable MSK benchmarking services need to collect consistent, standardised outcomes and, therefore, we have developed a recommendation on a minimum MSK ‘core outcome set’ of Patient Reported Outcome Measures (PROMs) and Patient Reported Experience Measures (PREMs) (PROMs: MSK‐HQ, NPRS, WPAI; PREMs: National MSK PREM). In addition, we make recommendations on the use of a standardised evidence‐based method for case‐mix adjustment and outlier identification (using the following baseline demographics and clinical factors; age, sex, ethnicity, pain site, comorbidities, duration of symptoms, previous surgery, previous pain episodes), alongside considerations on how this data should be integrated and reported within NHS systems.ConclusionsCapturing high quality MSK data in a standardised, consistent, and sustainable way is a significant challenge. Policy holders, commissioners, managers, and clinicians need to be realistic with expectations, and take time to explore barriers to implementation including, funding, digital infrastructure/intra‐operability, data sharing/governance, digital literacy, and local/national leadership. Next steps include developing a national MSK audit programme to provide a benchmarking model to support continuous improvements in care quality for patients living with MSK conditions.
A mixed element analysis of the Biot's model with Darcy–Forchheimer flow
Authors: Li Hongpeng , Rui Hongxing 
Published: August 2022

AbstractIn this article, we consider the three‐field Biot's consolidation model, in which the flow's velocity is described by Darcy–Forchheimer law. The model is nonlinear and the unknown variables are the displacement of the solid phase, fluid flux, and pore pressure. The linear finite element is proposed to approximate the solid displacement and the RT mixed finite element is proposed to approximate the fluid flux and pore pressure. The error estimates is given for semidiscrete scheme and fully discrete scheme. When analyzing the fully discrete scheme, no time step restriction is needed. Numerical tests for this method confirm the accuracy of the P1‐RT0‐P0 method when the constraint storage coefficient is positive and is null.
Ursolic acid incorporated nanofibers improves chondrogenic differentiation of mesenchymal stem cells
Authors: Gohari Zahra , Baghaei Ahmadali , Mahboudi Hossein , Hashemi Javad , Rahmati Mohammad , Islami Maryam , Mansouri Vahid 
Published: August 2022

AbstractCartilage injuries and osteoarthritis are among the most common problems of the elderly in the world, and common treatments are limited to relieving pain. Today, tissue‐engineering is one of the most important hopes of finding a cure to overcome these problems. Therefore, the present study aimed to examine the potential impact of Ursolic acid (UA) blended with electrospun nanofibrous scaffolds fabricated by polycaprolactone (PCL) and poly(L‐lactic acid) (PLLA) on the chondrogenesis capacity of the mesenchymal stem cells (MSCs). Characterization results of the scaffolds revealed that the hydrophilicity and biocompatibility of the PCL‐PLLA nanofibers increased significantly and therefore MSCs attachment and proliferation improved in comparison with empty nanofibers. In addition, differentiation evaluation was also indicated that the expression level of chondrogenic‐related genes was increased significantly in MSCs differentiated on the PCL‐PLLA‐UA nanofibers compared to the differentiated cells on the PCL‐PLLA nanofibers. Alcian blue staining was also revealed that glycosaminoglycans production was amplified significantly in the cells differentiated on the PCL‐PLLA‐UA nanofibers. Fibronectin protein expression that is an important pre‐cartilage condensation marker was also increased in MSCs differentiated on the UA containing scaffold. In summary, the results indicated a significant improvement in the chondrogenic differentiation potential of the MSCs when differentiated on the PCL‐PLLA‐UA nanofibers. It can be concluded that this cell‐scaffold combination can be suggested as potential candidate for cartilage tissue‐engineering applications.
What caregivers believe affected the quality of implementation of asthma‐related family management models (AFMM) during COVID‐19: A phenomenological qualitative study
Authors: Yi Mo , Bao Jingxian , Wang Jingjing , Zhang Zeyi , Jia Yuanmin , Zhao Baosheng , Fang Jinxia , Chen Ou 
Published: August 2022

AbstractPurposeThe recurrent COVID‐19 epidemic in China has disrupted many aspects of daily life for children with asthma and their caregivers, while negatively impacting their asthma family management models (AFMM). This phenomenological qualitative study identifies what affects the quality of implementation of AFMM in this population and outlines potential coping strategies for the caregivers.MethodsWe used purposive sampling to conduct semistructured interviews with primary caregivers of school‐age children with asthma from community healthcare centers (CHCs), which focused on understanding what factors influenced caregivers' implementation of AFMM during quarantine. The Colaizzi seven‐step method was used to independently code and categorize the transcript and to generate themes and identify associated key subthemes.ResultsTwenty‐four caregivers were interviewed, and they provided greater insight into barriers and motivators to implement AFMM. The three themes and nine relevant subthemes generated, (a) the “individual‐family” internal‐level factors: weak health literacy and beliefs, quietly changing family relationships, the dramatic increase in the care burden, gradual adjustment of negative psychology; (b) the “hospital‐community” external‐level factors: the endless power of peer support, strict community quarantine policy; and (c) the “health system‐public” social‐level factors: the enormous potential of internet‐based telemedicine, improved public awareness of prevention, government's prompt assistance.ConclusionsThis qualitative study reveals that the quality of AFMM implementation during pandemic is impacted by three different levels. Therefore, a targeted and comprehensive caring model that provides caregivers with the necessary coping strategies around these three levels is needed to achieve better asthma control outcomes.
Is the ‘student city’ lost? The rhythms of Lodz as a consumption‐oriented student city through the COVID‐19 pandemic lens
Authors: Zasina Jakub , Nowakowska Aleksandra 
Published: August 2022

AbstractThe COVID‐19 pandemic calls into question the hosting of students as an urban growth formula after the spread of online education. Therefore, we look at Lodz, Poland, to understand how student cities operate during the pandemic and gain insights into their futures. We unfold the prepandemic and intrapandemic rhythms of students' presence and activities in Lodz's time‐space and their attitudes toward the postpandemic future. We show that the pandemic spurred many students to escape from Lodz and changed the activities of those staying in the city by limiting their frequencies and locations. However, we expect students to repopulate Lodz, although its postpandemic existence might evolve through further rhythm changes. Moreover, it will depend not only on the students' demand for higher educationper se but also for collective consumption opportunities. Therefore, the pandemic itself does not seem to render the idea of a ‘student city’ obsolete in the long term.
Pre‐ and post‐yield bond, tension‐stiffening, and cracking in ultra‐high performance fiber reinforced concrete
Authors: Sturm Alexander B. , Visintin Phillip 
Published: August 2022

AbstractIn reinforced concrete elements, tension‐stiffening strongly influences deflections and crack‐widths at the serviceability limit, and plastic hinge rotation at the ultimate limit. Modeling has shown the impact of tension‐stiffening at the ultimate limit to be particularly important when ultimate failure is governed by reinforcement rupture, which has been is common in ultra‐high performance fiber reinforced concrete (UHPFRC) elements. It is further known that the magnitude of tension‐stiffening and crack opening is proportional to both the reinforcement ratio of the tension chord and the diameter of the reinforcing bar. Despite this understanding, very little testing has been undertaken to quantify the bond between larger diameter reinforcement and UHPFRC and also on the resulting impact to tension‐stiffening and concrete cracking. To address these issues, in this paper a series of bond and tension‐stiffening tests are undertaken on ultra‐high performance concretes both with and without steel fibers. The result of the experiments is used to develop a local bond stress slip relationship applicable to both pre‐ and post‐yield. When implemented in a partial‐interaction model, it is shown that the new bond model can be used to predict pre‐ and post‐yield tension‐stiffening and crack‐widths.
Zeolite Imidazolate Frameworks (ZIFs) Derived Nanomaterials and their Hybrids for Advanced Secondary Batteries and Electrocatalysis
Authors: Li Xiaotong , Liang Huajian , Liu Xinlong , Zhang Yufei , Liu Zili , Fan Haosen 
Published: August 2022

AbstractZeolite imidazolate frameworks (ZIFs), as a typical class of metal‐organic frameworks (MOFs), have attracted a great deal of attention in the field of energy storage and conversation due to their chemical structure stability, facile synthesis and environmental friendliness. Among of ZIFs family, the zinc‐based imidazolate framework (ZIF‐8) and cobalt‐based imidazolate framework (ZIF‐67) have considered as promising ZIFs materials, which attributed to their tunable porosity, stable structure, and desirable electrical conductivity. To date, various ZIF‐8 and ZIF67 derived materials, including carbon materials, metal oxides, sulfides, selenides, carbides and phosphides, have been successfully synthesized using ZIFs as templates and evaluated as promising electrode materials for secondary batteries and electrocatalysis. This review provides an effective guide for the comprehension of the performance optimization and application prospects of ZIFs derivatives, specifically focusing on the optimization of structure and their application in secondary batteries and electrocatalysis. In detail, we present recent advances in the improvement of electrochemical performance of ZIF‐8, ZIF‐67 and ZIF‐8@ZIF‐67 derived nanomaterials and their hybrids, including carbon materials, metal oxides, carbides, oxides, sulfides, selenides, and phosphides for high‐performance secondary batteries and electrocatalysis.
Recent Developments and Research Avenues for Polymers in Electric Vehicles
Authors: Gupta Prashant , Toksha Bhagwan , Patel Bhargav , Rushiya Yash , Das Paramita , Rahaman Mostafizur 
Published: August 2022

AbstractPlastics have been an indispensable material of choice in automobiles with wide range of applications such as interior, exterior, under the hood, and lighting/wiring applications. The prime motive of inclusion of these materials is increase in fuel efficiency and reduction in carbon footprint by replacing the energy intensive metallic counterparts. The current decade i. e., the 2020s has seen a recent surge in the sales of electronic vehicles. Although these numbers are promising, the growth in the rest of the parts of the world is not encouraging. It is primarily due to the skepticism involving battery life and efficiency, profitability, and environmental footprint when compared to conventional and hybrid vehicles. Also, a more concerted effort is needed in the lagging areas in order to install the required infrastructure. The emergence of plastics in the development and acceptance of e‐vehicles is going to be pivotal especially when the efficiency and profitability are considered as they give the required freedom to the engineers for the design and development of various parts and sizes by replacing the bulkier and more dense materials. Also, the research on bionanocomposites has received great interest from the research community due to their versatility in application along with their eco‐friendly nature throughout the lifecycle starting from feedstock up to end‐of‐life treatment. This review paper will be one of its kind to present a critical review of the recent developments of polymers suitable for use in e‐vehicles. Also, a comprehensive discussion comprising of newer research areas for polymers in their use for e‐vehicles will be presented.
Artemisia argyiextract amelioratesIL‐17A‐induced inflammatory response by regulation of NF‐κB and Nrf2 expression inHIG‐82 synoviocytes
Authors: Chen Jhong‐Kuei , Kuo Chia‐Hua , Kuo Wei‐Wen , Day Cecilia Hsuan , Wang Tso‐Fu , Ho Tsung‐Jung , Lin Pi‐Yu , Lin Shinn‐Zong , Shih Tzu‐Ching , Shih Cheng‐Yen , Huang Chih‐Yang , Lu Cheng‐You 
Published: August 2022

AbstractRheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease that results in joint destruction and disability in the adult population. RA is characterized by the accumulation and proliferation of fibroblast‐like synoviocytes. Many pro‐inflammatory mediators are associated with RA, such as interleukin (IL)‐1β, IL‐6, IL‐17, cyclooxygenase‐2 (COX‐2), and nuclear factor kappa B (NF‐κB). Furthermore, IL‐17 upregulates the production of other pro‐inflammatory mediators, including IL‐1β and IL‐6, and promotes the recruitment of neutrophils in RA.Artemisia argyi, a traditional Chinese herbal medicine, is used for the treatment of diseases associated with inflammation and microbial infections. In this study, synoviocytes (HIG‐82) were treated with varying doses ofA. argyiextract (AAE) following IL‐17A stimulation. Proliferation of the IL‐17A‐stimulated cells was increased compared to that of the non‐stimulated control cells. However, cell proliferation decreased significantly in a dose‐dependent manner following AAE treatment. Treatment of IL‐17A‐stimulated cells with AAE resulted in decreased levels of phosphorylated (p)‐NF‐κB, p‐IκB‐α, and COX‐2. Enzyme‐linked immunosorbent assay results showed that IL‐1β and IL‐6 levels were increased in the IL‐17A‐stimulated group but decreased in the AAE treatment group. Additionally, we found that AAE facilitated nuclear factor erythroid 2‐related factor 2 (Nrf2) expression and promoted its nuclear translocation, thereby inducing the expression of heme oxygenase‐1. Moreover, AAE did not attenuate IL‐17A‐induced inflammatory mediator production in the presence of ML385, an Nrf2‐specific inhibitor. These results suggest that the downregulation of expression of pro‐inflammatory cytokines and the transcription factor NF‐κB by AAE may be a potential therapeutic strategy for reducing inflammation associated with RA.