bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights into the synergistic effect between nickel and molybdenum for catalyzing urea electrooxidation
Authors: Wang Jiaqi , Mo Funian , Fei Jinbo , Ling Wei , Cui Mangwei , Lei Hao , Jiang Li , Huang Yan 
Published: September 2022

AbstractThe efficiency of many clean technologies, such as urea fuel cells, hydrogen production from urea‐containing water splitting, and sewage treatment, and so forth, is restricted due to the sluggish kinetics of the urea oxygen reaction (UOR). Mo‐doped Ni‐based catalysts are excellent for UOR because of the synergistic effect between Ni and Mo. However, such applications have indeed been hampered by a lack of mechanistic comprehension. Here, we fabricate Mo‐Ni(OH)2 nanosheets for efficient UOR electrocatalysis with activity at least twice higher than Ni(OH)2 nanosheets. Various in situ characterizations including Raman, differential electrochemical mass spectrometry and Fourier transform infrared spectroscopy reveals that the doping of Mo lowers the onset potential required for Ni2+/Ni3+ conversion and promotes the coupling of the N–N bond inside the molecule and the fracture of the double bond between C and O in the urea molecule. In addition, an entirely flexible direct urea fuel cell with the Mo‐Ni(OH)2 electrocatalyst delivers a maximum output power density of 0.78 mW cm−2 and complete flexibility for the first time. Our research significantly promotes the mechanistic understanding of UOR electrocatalysis and its applications.
Development of a risk model based on immune genes in patients with colon adenocarcinoma
Authors: Wei Laiming , Xu Jing , Hu Xueyou , Lyu Gang 
Published: September 2022

AbstractBackgroundThe rapidly increasing morbidity and the poor prognosis making the colon adenocarcinoma not only common but also highly malignant. On the other hand, immunotherapy emerges as a therapeutic modality of colon cancer recently. In this study, we developed a prognostic risk model that is based on immune genes, which could predict the overall survival (OS) of patients with colon adenocarcinoma.MethodsThe Cancer Genome Atlas (TCGA) database was used to download both transcriptomic and clinical data, and the ImmPort database was used to obtain immune genes. The least absolute shrinkage and selection operator (LASSO)‐Cox regression was adopted to further select the key genes with prognostic value. Then the key genes were inputted into stepwise regression to calculated each patient's immune‐related risk score (immune score). Survival, survminer packages and bilateral tests in R language were adopted to determine the optimal cut‐off value (cut‐off value) for the risk score. This threshold divides patients into immune‐score high‐risk and low‐risk groups. The differences in the levels of infiltrating immune cells and stromal cells in the high and low immune risk groups were then calculated and compared by the CIBERSORT algorithm.ResultsAccording to our results, a prognostic risk model was constructed based upon 26 immune‐related genes. High immune score was shown to be a poor prognostic factor for colon adenocarcinoma patients, such as overall survival, progress free survival for different therapies, and tumor stages. High immune score was also associated with the abundance of CD4+ T cells and CD8+ T cells. In addition, the high immune score group, the expression levels of LMTK3, LAG3 and PD‐L1 were higher than those in the low score group.ConclusionWe developed a 26‐immune gene model of colon adenocarcinoma to predict patient's survival. This model might be used in clinical practice as a prognostic instrument for patients diagnosed with colon adenocarcinoma.
Transdiagnostic symptom networks in relation to mental health service use in community youth
Authors: Imperiale Marina N. , Lieb Roselind , Calkins Monica E. , Meinlschmidt Gunther 
Published: September 2022

AbstractObjectiveThe objective of this study is to scrutinize whether psychopathology symptom networks differ between those with and without lifetime: treatment seeking, treatment and treatment of longer duration.MethodsWe created non‐exclusive groups of subjects with versus without lifetime treatment seeking, treatment and treatment of mid‐long‐term duration. We estimated Ising models and carried out network comparison tests (NCTs) to compare (a) overall connectivity and (b) network structure. Furthermore, we examined node strength. We used propensity score matching (PSM) to minimize potential confounding by indication for service use.ResultsBased on data from 9,172 participants, there were no statistically significant differences in overall connectivity and network structure in those with versus without lifetime: treatment seeking (p = .75 and p = .82, respectively), treatment (p = .63 and p = .49, respectively) and treatment of mid‐longterm duration (p = .15 and p = .62, respectively). Notably, comparing networks with versus without service use consistently revealed higher node strength in ‘obsessions’ and ‘aggression’ and lower node strength in ‘elevated mood’ in all networks with service use.ConclusionsFindings suggest that after adjusting for potential confounding by indication for service use, there was no indication of an association in overall connectivity or network structure for lifetime treatment seeking, treatment and treatment of longer duration. However, selected structurally important symptoms differed consistently in all three comparisons. Our findings highlight the potential of network analysis methods to examine treatment mechanisms and outcomes. Specifically, more granular network characteristics on the node level may complement and enrich traditional outcomes in clinical research.
Tal2 is required for generation of GABAergic neurons in the zebrafish midbrain
Authors: Wang Ruihong , Guo Shaojuan , Yang Lixin 
Published: September 2022

AbstractBackgroundIn the zebrafish midbrain, GABAergic neurons develop from precursors located in the nucleus of the medial longitudinal fasciculus (nMLF). However, the precise mechanisms that underline generation of the nMLF GABAergic neuron are poorly understood.ResultsGABAergic neurons in the nMLF co‐express transcription factors tal2, gata2a, gata3, and nkx1.2lb. The Nodal‐related gene and shh signaling are required for differentiation of nMLF GABAergic neuron precursors. Tal2 is important for nMLF GABAergic neurogenesis. Disruption of Tal2, embryos completely lack the GABA‐synthesizing enzyme glutamic acid decarboxylase 67 gene (gad67) expressing cells in the nMLF, and the whole nkx1.2lb expressing cells in the midbrain. Although almost all tal2‐expressing cells in the diencephalon and/or nMLF are gata2a‐ and gata3‐positive, simultaneous knockdown of gata2a and gata3 does not affect either tal2 or gad67 expression.ConclusionsIn the zebrafish midbrain, expression of tal2, gata2a, and/or gata3 is independent of each other. The function of gata2a and gata3 is dispensable for generation of GABAergic neuron in the nMLF. This suggests that the functional connections of the regulatory genes leading to generation of nMLF GABAergic neurons have diverged between mouse and zebrafish.
Orofacial pain and dysfunction in patients with Parkinson's disease: A scoping review
Authors: Verhoeff Merel C. , Koutris Michail , Tambach Sharine , Eikenboom Denise , de Vries Ralph , Berendse Henk W. , van Dijk Karin D. , Lobbezoo Frank 
Published: September 2022

AbstractBackgroundParkinson's disease (PD) is commonly known as a disorder that affects the smooth performance of body movements. In addition to the motor impairments, patients with PD often experience pain. Both motor impairments and pain can occur throughout the body, hence including the orofacial region. However, currently, there is a lack of knowledge on the orofacial manifestations. Since orofacial pain and dysfunction can, amongst others, reduce the quality of life of patients with PD, it is important to explore the prevalence of these symptoms in the PD population.ObjectiveTo provide a broad overview of the relevant literature on orofacial pain and dysfunction in patients with PD. Furthermore, we aim to generate hypotheses for future research on this topic.Databases and data treatmentA literature search (in PubMed, Embase.com, Web of Science [Core collection], and Cochrane Library) was performed on 20 January 2022, in collaboration with a medical librarian. In total, 7180 articles were found, of which 50 were finally included in this scoping review.ResultsIn the included studies, pain (e.g. orofacial pain (N = 2) and temporomandibular disorder pain (N = 2)), orofacial motor dysfunction (e.g. limited jaw movements (N = 10), reduced maximum muscle output (N = 3), chewing difficulties (N = 9), unspecified TMD (N = 3), sensory disturbances (N = 1)), and bruxism (N = 3) were observed more often in patients with PD than in healthy controls.ConclusionPatients with PD experience more pain in the orofacial area and more dysfunction of the masticatory system than their healthy peers.SignificanceThis scoping review can increase health care providers' awareness of the problems that can be encountered in the orofacial area of PD patients, especially pain syndromes also occur in the orofacial region and not only in the extremities. Besides, dysfunction of the orofacial area is elaborated in this scoping review, which helps to understand that this limits PD patients' quality of life. Further, the outcomes of this scoping review can assist in encouraging collaboration between medicine and dentistry. Finally, this scoping review suggests new research areas, based on the gaps identified in the current literature on this topic. Ultimately, this will improve individualized strategies for reducing orofacial pain and/or dysfunction in PD patients.
Performance evaluation of a compact designed electric power system composed of a two‐stroke gasoline engine, generator, and battery for high‐endurance unmanned aerial vehicles
Authors: Gang Byeong Gyu , Kim Keun‐Bae 
Published: September 2022

AbstractAn electric power system comprising a two‐stroke gasoline engine integrated with a generator and a battery is designed, and its performance is evaluated on the ground if it can provide constant 6 kW‐scale electric power for UAVs. The reciprocal engine is fabricated to have opposed pistons connected to the crankshaft, which can provide the house to hold the generator at its end, resulting in a compact design. This system integration allows the generated power to be readily manipulated by adjusting the engine rpm. In addition, the generator operates in two modes: a starter mode when starting an engine initially, and then a power unit mode after reaching 4500 engine rpm. In turn, a power supply and starter mode were combined in a single unit. The battery is adopted to momentarily cover insufficient power when a high load is inevitable, and its capacity is tested by applying an 11 kW electric load that the engine‐generator itself cannot cover. Thus, a hybrid electric power plant is formed by incorporating different power sources that can satisfy various load requests up to 11 kW, and it can extend flight endurance by alternating the main power between an engine generator and a battery.
Experimental and simulation study on the combustion fire spreading characteristics of aluminum composite panels with different thicknesses
Authors: Zhang Yipeng , Zhou Ru , Wu Tianran , Huang Chenxi , Chen Zhihao , Jiang Juncheng 
Published: September 2022

AbstractTo study the effect of thickness on the fire spreading characteristics of aluminum composite panels, a reduced‐scale test bench was built to simulate the development of an overflow fire in a high‐rise building. Analysis of the fire spreading characteristics was performed in terms of the flame shape, flame height, fire spread rate, and temperature change. Then, an Fire Dynamics Simulatior model was established to verify the accuracy of the experiment using numerical simulations. The results showed that the flame shape of the 3 and 4 mm aluminum composite panels was a triangular cone, while the flame shape of the 5 and 6 mm aluminum composite panels was approximately rectangular. By establishing the dimensionless flame height, the flame height increased with the panel thickness. The fire spread rate of the aluminum composite panels increased first and then decreased upon increasing the thickness, which was consistent with the simulation results. The temperature change curves all showed a rapid initial increase and then a stable temperature in the later period. The simulation results conformed well to the experimental results.
Numerical modeling of flow past a volumeless and thin rigid body using direct forcing immersed boundary method
Authors: Tewolde Desta Goytom , Wei Zi‐Hsuan , Chern Ming‐Jyh 
Published: September 2022

AbstractThe new capability has been added as the numerical method for modeling volumeless and thin rigid bodies to the direct forcing immersed boundary (DFIB) method. The DFIB approach is based on adding a virtual force to the Navier–Stokes equations of incompressible flow to account for the interaction between the fluid and structures. The volume of a solid function (VOS) identifies the stationary or moving solid structures in a given fluid domain. A new VOS‐based algorithm was developed to identify thin, rigid structure boundary points in fluid flow and ensure that the fluid cannot cross through the boundary of a thin rigid structure while moving or stationary. The DFIB method was first validated in a three‐dimensional (3D) turbulent flow over a circular cylinder. The large‐eddy simulation simulated the turbulent flow scales. The proposed algorithm was tested using a 3D turbulent flow past a stationary and rotating Savonius wind turbine that functions as a thin, rigid body. The validation results showed that the selected DFIB approach, combined with the novel algorithm, could simulate a thin, volumeless, rigid structure that is stationary and rotating in incompressible turbulent flows. The current method is also applicable for two‐way fluid‐structure interaction problems.
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis
Authors: Knorr Jana , Kaufmann Benedikt , Inzaugarat Maria Eugenia , Holtmann Theresa Maria , Geisler Lukas , Hundertmark Jana , Kohlhepp Marlene Sophia , Boosheri Laela M. , Chilin‐Fuentes Daisy R. , Birmingham Amanda , Fisch Kathleen M. , Schilling Joel D. , Loosen Sven H. , Trautwein Christian , Roderburg Christoph , Demir Münevver , Tacke Frank , Hoffman Hal M. , Feldstein Ariel E. , Wree Alexander 
Published: September 2022

Background and Aims:
Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis. Mechanisms and downstream signaling remain incompletely understood. Here, we studied the role of IL‐18 in hepatic stellate cells (HSCs), and its impact on liver fibrosis.

Approach and Results:
We observed significantly increased serum levels of IL‐18 (128.4 pg/ml vs. 74.9 pg/ml) and IL‐18 binding protein (BP; 46.50 ng/ml vs. 15.35 ng/ml) in patients with liver cirrhosis compared with healthy controls. Single cell RNA sequencing data showed that an immunoregulatory subset of murine HSCs highly expresses Il18 and Il18r1. Treatment of cultured primary murine HSC with recombinant mouse IL‐18 accelerated their transdifferentiation into myofibroblasts. In vivo, IL‐18 receptor‐deficient mice had reduced liver fibrosis in a model of fibrosis induced by HSC‐specific NLRP3 overactivation. Whole liver RNA sequencing analysis from a murine model of severe NASH‐induced fibrosis by feeding a choline‐deficient, L‐amino acid‐defined, high fat diet showed that genes related to IL‐18 and its downstream signaling were significantly upregulated, and Il18

−/−
mice receiving this diet for 10 weeks showed protection from fibrotic changes with decreased number of alpha smooth muscle actin‐positive cells and collagen deposition. HSC activation triggered by NLRP3 inflammasome activation was abrogated when IL‐18 signaling was blocked by its naturally occurring antagonist IL‐18BP. Accordingly, we observed that the severe inflammatory phenotype associated with myeloid cell‐specific NLRP3 gain‐of‐function was rescued by IL‐18BP.

Conclusions:
Our study highlights the role of IL‐18 in the development of liver fibrosis by its direct effect on HSC activation identifying IL‐18 as a target to treat liver fibrosis.
Experimental study of dynamic DC stray current corrosion of X70 steel
Authors: Qin Huimin , Zhang Tao , Du Yanxia , Zhang Lei , Zhang Yuxing , Liu Hui 
Published: September 2022

AbstractIn this paper, an experimental investigation on X70 steel was performed with respect to dynamic DC stray current interference in a soil‐simulated solution and in quartz sand. The results showed that the interference period had a huge impact on the corrosion rate. When the interference period was less than 100 s, corrosion rates in the two testing conditions were less than 12% of that induced by steady DC corrosion with an equivalent current. When the interference period was longer than 100 s, the corrosion rate in the soil‐simulated solution increased more significantly than that in quartz sand. Also, when the interference period was longer than 1 h, the corrosion rate in the soil‐simulated solution was approximately equal to the Faraday theory corrosion rate. However, the corrosion rate in quartz sand was still less than 81% of the Faraday theory corrosion rate, even though the interference period had been increased to 16 h. The difference of the corrosion rates in the two testing conditions was probably because of the different capacities of charge consumption by the capacitance effect of the electric double layer as well as the different charge consumption due to the extra reaction of species other than iron.
Connecting chemical exposome to human health using high‐resolution mass spectrometry‐based biomonitoring: Recent advances and future perspectives
Authors: Chen Yuan‐Chih , Hsu Jing‐Fang , Chang Chih‐Wei , Li Shih‐Wen , Yang Ya‐Chi , Chao Mu‐Rong , Chen Hauh‐Jyun C. , Liao Pao‐Chi 
Published: September 2022

AbstractCompared with the rapid advances in genomics leading to broad understanding of human disease, the linkage between chemical exposome and diseases is still under investigation. High‐resolution mass spectrometry (HRMS) is expected to accelerate the process via relatively accurate and precise biomonitoring of human exposome. This review covers recent advancements in biomonitoring of exposed environmental chemicals (chemical exposome) using HRMS described in the 124 articles that resulted from a systematic literature search on Medline and Web of Science databases. The analytical strategic aspects, including the selection of specimens, sample preparation, instrumentation, untargeted versus targeted analysis, and workflows for MS‐based biomonitoring to explore the environmental chemical space of human exposome, are deliberated. Applications of HRMS in human exposome investigation are presented by biomonitoring (1) exposed chemical compounds and their biotransformation products; (2) DNA/protein adducts; and (3) endogenous compound perturbations. Challenges and future perspectives are also discussed.
Biomaterials to promote vascularization in tissue engineering organs and ischemic fibrotic diseases
Authors: Zhao Wenyan , Zhu Junpeng , Hang Jiaxin , Zeng Wen 
Published: September 2022

AbstractThe formation of the complex and fully functional vascular networks in pivotal organs is a key challenge in tissue engineering research. Functional blood vessels not only maintain oxygen and nutrient delivery but also effectively get rid of waste. Recently, a deep understanding of the vascular tissue structure and tissue microenvironment helps to make several great progress in the construction of highly complex and biomimetic vascularized tissues and organs, using biomaterials such as hydrogels and biomaterial composites. In this review, we summarized the advantages and research progress of biomaterials used in constructing the vascularized tissue in tissue engineering regeneration, ischemic fibrosis, and so on. We also discussed the progression of vascularization in organs and organoids. First, we discuss the applications of biomaterial‐based vascularized tissue in bone, skin, and other tissue regeneration. Secondly, we discussed biomaterials and their components in promoting vascularization of ischemic fibrosis organs such as cerebral infarction, myocardial infarction, and renal fibrosis. In addition, we also introduced the strategies and applications that biomaterials function as a biomimetic extracellular matrix performed to construct vascularized tissues or organs in vitro. Finally, coming opportunities and challenges are also discussed and commented on.
Lactobacillus acidophilus KBL409 Reduces Kidney Fibrosis via Immune Modulatory Effects in Mice with Chronic Kidney Disease
Authors: Kim Hyoungnae , Nam Bo Young , Park Jimin , Song Seokcheon , Kim Woon‐Ki , Lee Kiuk , Nam Tae‐Wook , Park Jung Tak , Yoo Tae‐Hyun , Kang Shin‐Wook , Ko GwangPyo , Han Seung Hyeok 
Published: September 2022

ScopeIntestinal dysbiosis has been reported to play an important role in the pathogenesis of various diseases, including chronic kidney disease (CKD). Here, to evaluate whether probiotic supplements can have protective effects against kidney injury in an animal model of CKD is aimed.Methods and resultsAn animal model of CKD is established by feeding C57BL/6 mice a diet containing 0.2% adenine. These model mice are administered Lactobacillus acidophilus KBL409 daily for 4 weeks. Features of adenine‐induce CKD (Ade‐CKD) mice, such as prominent kidney fibrosis and higher levels of serum creatinine and albuminuria are improved by administration of KBL409. Ade‐CKD mice also exhibit a disrupted intestinal barrier and elevate levels of TNF‐α, IL‐6, and 8‐hydroxy‐2′‐deoxyguanosine. These changes are attenuated by KBL409. Administration of KBL409 significantly reduces macrophage infiltration and promotes a switch to the M2 macrophage phenotype and increasing regulatory T cells. Notably, the NLRP3 inflammasome pathway is activated in the kidneys of Ade‐CKD and decreases by KBL409. In primary kidney tubular epithelial cells treated with p‐cresyl sulfate, short‐chain fatty acids significantly increase M2 macrophage polarization factors and decrease profibrotic markers.ConclusionsThese results demonstrate that supplementation with the probiotic KBL409 has beneficial immunomodulating effects and protects against kidney injury.