bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal detection of chromosomal abnormalities and copy number variants in fetuses with congenital gastrointestinal obstruction
Authors: Meng Xinyue , Jiang Lili 
Published: January 2022

Abstract
Background
Congenital gastrointestinal obstruction (CGIO) mainly refers to the stenosis or atresia of any part from the esophagus to the anus and is one of the most common surgical causes in the neonatal period. The concept of genetic factors as an etiology of CGIO has been accepted, but investigations about CGIO have mainly focused on aneuploidy, and the focus has been on duodenal obstruction. The objective of this study was to evaluate the risk of chromosome aberrations (including numeric and structural aberrations) in different types of CGIO. A second objective was to assess the risk of abnormal CNVs detected by copy number variation sequencing (CNV-seq) in fetuses with different types of CGIO.

Methods
Data from pregnancies referred for invasive testing and CNV-seq due to sonographic diagnosis of fetal CGIO from 2015 to 2020 were obtained retrospectively from the computerized database. The rates of chromosome aberrations and abnormal CNV-seq findings for isolated CGIOs and complicated CGIOs and different types of CGIOs were calculated.

Results
Of the 240 fetuses with CGIO that underwent karyotyping, the detection rate of karyotype abnormalities in complicated CGIO was significantly higher than that of the isolated group (33.8% vs. 10.8%, p < 0.01). Ninety-three cases with normal karyotypes further underwent CNV-seq, and CNV-seq revealed an incremental diagnostic value of 9.7% over conventional karyotyping. In addition, the incremental diagnostic yield of CNV-seq analysis in complicated CGIOs (20%) was higher than that in isolated CGIOs (4.8%), and the highest prevalence of pathogenic CNVs/likely pathogenic CNVs was found in the duodenal stenosis/atresia group (17.5%), followed by the anorectal malformation group (15.4%). The 13q deletion, 10q26 deletion, 4q24 deletion, and 2p24 might be additional genetic etiologies of duodenal stenosis/atresia.

Conclusions
The risk of pathogenic chromosomal abnormalities and CNVs increased in the complicated CGIO group compared to that in the isolated CGIO group, especially when fetuses presented duodenal obstruction (DO) and anorectal malformation. CNV-seq was recommended to detect submicroscopic chromosomal aberrations for DO and anorectal malformation when the karyotype was normal. The relationship between genotypes and phenotypes needs to be explored in the future to facilitate prenatal diagnosis of fetal CGIO and yield new clues into their etiologies.
Modulation of chemoimmunotherapy efficacy in non-small cell lung cancer by sex and histology: a real-world, patient-level analysis
Authors: Tuminello Stephanie , Alpert Naomi , Veluswamy Rajwanth R. , Kumar Arvind , Gomez Jorge E. , Flores Raja , Taioli Emanuela 
Published: January 2022

Abstract
Background
It has been postulated that patient’s sex impacts response to immunotherapy. Sex modulation of immunotherapy benefit, however, has not yet been explored using patient-level data, where potential confounders, as well as histologic type, can be accounted for. Here we investigated the association between sex and chemoimmunotherapy efficacy for non-small cell lung cancer (NSCLC) using a large, nation-wide dataset.

Patients & methods
Stage IV NSCLC patients diagnosed in 2015 were identified in the National Cancer Database (NCDB). Patients were treated with either chemoimmunotherapy or chemotherapy alone. The efficacy of the addition of immunotherapy treatment by sex was investigated using both an adjusted Cox proportional hazards model and propensity-score matching, in both the overall cohort and stratified by histological subtype.

Results
2064 (16%) patients received chemoimmunotherapy and10,733 (84%) received chemotherapy alone. Adjusted survival analysis in the overall cohort showed that both males (hazards ratio (HR)adj: 0.80, 95% CI: 0.74–0.87) and females (HRadj: 0.83, 95% CI: 0.76–0.90) had better OS when treated with chemoimmunotherapy than chemotherapy alone, with no statistically significant interaction between sex and receipt of immunotherapy (p = 0.63). Propensity matching confirmed these results. However, for those with squamous cell histology, male patients derived more benefit from chemoimmunotherapy treatment than females (HRadj: 0.73, 95% CI: 0.58–0.91 vs HRadj: 1.03, 95% CI: 0.76–1.38; p for interaction = 0.07).

Conclusion
Male patients with squamous cell carcinoma may derive more benefit from chemoimmunotherapy treatment. Histology likely plays an important role in how sex modulates immunotherapy efficacy.
Vitamin D and the risk of latent tuberculosis infection: a systematic review and meta-analysis
Authors: Cao Yan , Wang Xinjing , Liu Ping , Su Yue , Yu Haotian , Du Jingli 
Published: January 2022

Abstract
Objective
Latent tuberculosis infection (LTBI) may be a risk of developing tuberculosis (TB) and thus a health hazard. The aim of this meta-analysis is to explore the association between vitamin D and LTBI.

Methods
Databases including PubMed, Embase, Scopus, and ProQuest were electronically searched to identify observational or interventional studies that reported the association between vitamin D and LTBI. The retrieval time is limited from inception to 30 September 2021. Two reviewers independently screened literature, extracted data, and assessed risk bias of included studies. Meta-analysis was performed by using STATA 12.0 software.

Results
A total of 5 studies involving 2 case–control studies and 3 cohort studies were included. The meta-analysis result showed that the risk of LTBI among individuals was not associated with high vitamin D level (OR 0.51, 95% CI 0.05–5.65, P = 0.58). The result from cohort studies also suggested that relatively high vitamin D level was not a protective factor for LTBI (RR = 0.56, 95%CI 0.19–1.67, P = 0.300).

Conclusions
Our meta-analysis suggested that serum vitamin D levels were not associated with incidence of LTBI, and relatively high serum vitamin D level was not a protective factor for LTBI. Further RCTs are needed to verify whether sufficient vitamin D levels and vitamin D supplementation reduces the risk of LTBI.
Finite element stress analysis of the bearing component and bone resected surfaces for total ankle replacement with different implant material combinations
Authors: Yu Jian , Zhao Dahang , Chen Wen-Ming , Chu Pengfei , Wang Shuo , Zhang Chao , Huang Jiazhang , Wang Xu , Ma Xin 
Published: January 2022

Abstract
Background
A proper combination of implant materials for Total Ankle Replacement (TAR) may reduce stress at the bearing component and the resected surfaces of the tibia and talus, thus avoiding implant failure of the bearing component or aseptic loosening at the bone-implant interface.

Methods
A comprehensive finite element foot model implanted with the INBONE II implant system was created and the loading at the second peak of ground reaction force was simulated. Twelve material combinations including four materials for tibial and talar components (Ceramic, CoCrMo, Ti6Al4V, CFR-PEEK) and three materials for bearing components (CFR-PEEK, PEEK, and UHMWPE) were analyzed. Von Mises stress at the top and articular surfaces of the bearing component and the resected surfaces of the tibia and talus were recorded.

Results
The stress at both the top and articular surfaces of the bearing component could be greatly reduced with more compliant bearing materials (44.76 to 72.77% difference of peak stress value), and to a lesser extent with more compliant materials for the tibial and talar components (0.94 to 28.09% difference of peak stress value). Peak stresses at both the tibial and talar bone-implant interface could be reduced more strongly by using tibial and talar component materials with smaller material stiffness (7.31 to 66.95% difference of peak stress value) compared with bearing materials with smaller material stiffness (1.11 to 24.77% difference of peak stress value).

Conclusions
Implant components with smaller material stiffness provided a stress reduction at the bearing component and resected surfaces of the tibia and talus. The selection of CFR-PEEK as the material of tibial and talar components and UHMWPE as the material of the bearing component seemed to be a promising material combination for TAR implants. Wear testing and long-term failure analysis of TAR implants with these materials should be included in future studies.
Open reduction and locked compression plate fixation, with or without allograft strut, for periprosthetic fractures in patients who had a well-fixed femoral stem: a retrospective study with an average 2-year follow-up
Authors: Lv Hui , Guo Xing , Wang Yuan Hui , Zhang Zhong Jie , Zou Long Fei , Xue Hao , Huang Deng Hua , Tan Mei Yun 
Published: January 2022

Abstract
Background
The use of cortical strut allograft has not been determined for Vancouver type B1 or C fracture. This study aimed to evaluate the short-term efficacy of locking compression plating with or without cortical strut allograft in managing these types of fractures.

Methods
We retrospectively assessed 32 patients (17 males, 15 females; 23–88 years, mean: 67.2 years) with Vancouver type B1 or C fractures. Seventeen patients (Group A; B1 fractures in 15 hips, C fractures in 2 hips) were treated with open reduction and internal fixation with locking compression plates (group A). The other 15 patients (Group B; B1 in 14 hips, C in 1 hip) were fixed by locking compression plating combined with cortical strut allografting (group B). The fracture healing rate, healing time, complications and function were compared between these two groups.

Results
The mean follow-up time was 32.4 months (12 to 66), and the overall fracture union rate of the 32 patients was 96.9%. Group B had a higher fracture union rate than Group A, but the difference was not statistically significant. Group A had one case of nonunion of type B1 fracture and one case of malunion; the mean time to fracture healing was 5.3 months (3 to 9). In group B, all patients reached bony union without malunion, with a mean time of fracture healing of 5.1 months (3 to 8).

Conclusion
Treatment of Vancouver type B1 or C fractures by locking compression plating, with or without cortical strut allografting, resulted in similar union rates in these patients. This suggest that, the use of cortical strut allografting should be decided cautiously.
High prevalence of acetabular rim osteophytes after hip arthroscopy for treatment of FAI
Authors: Gao Guanying , Liu Rongge , Dong Hanmei , Ao Yingfang , Wang Jianquan , Xu Yan 
Published: January 2022

AbstractBackgroundFew studies mentioned acetabular rim osteophytes (ARO) after arthroscopy for femoroacetabular impingement (FAI) in follow-up after primary hip arthroscopy. We found that many patients had postoperative ARO, which may lead to recurrent or secondary pincer-type deformity after primary hip arthroscopy for FAI and postoperative ARO sometimes even led to revision surgery. It is necessary to carry out related research on ARO.MethodsWe respectively evaluated consecutive cases who underwent hip arthroscopy in our hospital between January 2008 and January 2020. Radiographic examination was obtained for all patients preoperatively and postoperatively. Another CT scan was performed at least 6 months after surgery at final follow-up. Preoperative patient-reported outcomes (PROs) and PROs at final follow-up were obtained, including visual analog scale (VAS) for pain and modified Harris Hip Score (mHHS). The volume of ARO was calculated using mimics 21.0 software. According to the material of anchors and whether the anchors were used, patients were divided into absorbable group, non-absorbable group and no anchor group.ResultsA total of 71 patients were finally included in this study. Patients with postoperative ARO had higher VAS at final follow-up (P<0.05). Patients without postoperative ARO had higher mean mHHS at final follow-up (P = 0.08) and higher percentage of passing minimal clinical important difference. The percentage and volume of postoperative ARO was significantly higher in patients who underwent acetabuloplasty and labral repair (P<0.05). The percentage and volume of postoperative ARO in absorbable group were significantly higher than the other groups (P<0.05).ConclusionThere is a high percentage of ARO after hip arthroscopy for treatment of FAI and patients who have undergone labral repair and acetabuloplasty are more likely to have postoperative ARO. Using of absorbable anchors may increase the possibility and volume of postoperative ARO. Postoperative ARO may predict a worse clinical outcome.
Effect of type 2 diabetes on coronary artery ectasia: smaller lesion diameter and shorter lesion length but similar adverse cardiovascular events
Authors: Cai Zhongxing , Li Luqi , Wang Haoyu , Yuan Sheng , Yin Dong , Song Weihua , Dou Kefei 
Published: January 2022

Abstract
Background
Coronary artery ectasia (CAE) is a rare finding in coronary angiography and associated with poor clinical outcomes. Unlike atherosclerosis, diabetes mellitus (DM) is not commonly associated with CAE. This study aims to investigate the effect of type 2 diabetes mellitus (DM2) on coronary artery ectasia, especially the differences in angiographic characteristics and clinical outcomes.

Methods
Patients with angiographically confirmed CAE from 2009 to 2015 were included. Quantitative coronary angiography (QCA) was performed to measure the diameter and length of the dilated lesion. The primary endpoint was the maximum diameter and maximum length of the dilated lesion at baseline coronary angiography. The secondary endpoint was 5-year major adverse cardiovascular events (MACE), which was a component of cardiovascular death and nonfatal myocardial infarction (MI). Propensity score weighting (PSW) and propensity score matching (PSM) were used to balance covariates. Kaplan–Meier method and Cox regression were performed to assess the clinical outcomes.

Results
A total of 1128 patients were included and 258 were combined with DM2. In the DM2 group, the maximum diameter of dilated lesion was significantly lower (5.26 mm vs. 5.47 mm, P  = 0.004) and the maximum length of the dilated lesion was significantly shorter (25.20 mm vs. 31.34 mm, P  = 0.002). This reduction in dilated lesion diameter (5.26 mm vs. 5.41 mm, P  = 0.050 in PSW; 5.26 mm vs. 5.46 mm, P  = 0.007 in PSM, respectively) and length (25.17 mm vs. 30.17 mm, P  = 0.010 in PSW; 25.20 mm vs. 30.81 mm, P  = 0.012 in PSM, respectively) was consistently observed in the propensity score analysis. A total of 27 cardiovascular deaths and 41 myocardial infarctions occurred at 5-year follow-up. Compared with non-DM group, there were similar risks of MACE (6.02% vs. 6.27%; HR 0.96, 95% CI 0.54–1.71, P  = 0.894), cardiovascular death (2.05% vs. 2.61%; HR 0.78, 95% CI 0.29–2.05, P  = 0.605) and MI (4.07% vs. 3.72%; HR 1.11, 95% CI 0.54–2.26, P  = 0.782) in patients with DM2. Consistent result was observed in multivariable regression.

Conclusions
Compared to non-DM patients, patients with CAE and type 2 diabetes were associated with a smaller diameter and shorter length of dilated vessels, suggesting the important effect of DM2 on the pathophysiological process of CAE. Similar risks of MACE were found during 5-year follow up among diabetic and non-DM patients.
Malignancies in patients with cystic fibrosis: a case series
Authors: Appelt Dorothea , Fuchs Teresa , Steinkamp Gratiana , Ellemunter Helmut 
Published: January 2022

Abstract
Background
Previous reports have shown an increased number of colorectal cancers in patients with cystic fibrosis. We assessed the database of our cystic fibrosis center to identify patients with all kinds of cancer retrospectively. All patients visiting the Cystic Fibrosis Centre Innsbruck between 1995 and 2019 were included.

Case presentation
Among 229 patients with cystic fibrosis treated at the Cystic Fibrosis Centre in Innsbruck between 1995 and 2019, 11 subjects were diagnosed with a malignant disease. The median age at diagnosis was 25.2 years (mean 24.3 years). There were four gynecological malignancies (cervical intraepithelial neoplasia and cervical cancer), two hematological malignancies (acute lymphocytic leukemia), one gastrointestinal malignancy (peritoneal mesothelioma), and four malignancies from other origins (malignant melanoma, neuroblastoma, adrenocortical carcinoma, and thyroid cancer). One malignancy occurred after lung transplantation. There was a strong preponderance of females, with 10 of the 11 cases occurring in women. Six deaths were attributed to cancer.

Conclusions
Most diagnoses were made below 30 years of age, and half of the subjects died from the malignant disease. Awareness of a possible malignancy is needed in patients with atypical symptoms. Regular screenings for cancer should also be considered, not only for gastrointestinal tumors.
A subclass of meromorphic Janowski-type multivalent q-starlike functions involving a q-differential operator
Authors: Ahmad Bakhtiar , Mashwani Wali Khan , Araci Serkan , Mustafa Saima , Khan Muhammad Ghaffar , Khan Bilal 
Published: January 2022

AbstractKeeping in view the latest trends toward quantum calculus, due to its various applications in physics and applied mathematics, we introduce a new subclass of meromorphic multivalent functions in Janowski domain with the help of the q-differential operator. Furthermore, we investigate some useful geometric and algebraic properties of these functions. We discuss sufficiency criteria, distortion bounds, coefficient estimates, radius of starlikeness, radius of convexity, inclusion property, and convex combinations via some examples and, for some particular cases of the parameters defined, show the credibility of these results.
Couple’s Satisfaction among Lebanese adults: validation of the Toronto Alexithymia Scale and Couple Satisfaction Index-4 scales, association with attachment styles and mediating role of alexithymia
Authors: El Frenn Yara , Akel Marwan , Hallit Souheil , Obeid Sahar 
Published: January 2022

Abstract
Background
Lebanon is passing through an economic crisis leading to a decreased monthly income within a couple and more couple’s dissatisfaction. Furthermore, many studies postulate that the different types of attachment styles affect the romantic relationship experienced between adults. The main objectives of our study were to (1) validate the Toronto Alexithymia Scale (TAS) and Couple Satisfaction Index-4 (CSI-4) scales, and (2) assess the association between attachment styles and couple satisfaction and evaluate the mediating role of alexithymia in these associations.

Methods
This cross-sectional study involved 445 Lebanese participants (April–May 2021). A confirmatory factor analysis (CFA) was carried out using SPSS AMOS v.24 on the couple satisfaction index and Toronto alexithymia scales’ items. A linear regression was conducted, taking the couple satisfaction index as the dependent variable.

Results
The CFA results of the CSI-4 scale indicated an excellent fit (χ2/df = 3.845/2 = 1.92, TLI = 0.992, RMSEA = 0.046 [95% CI 0.001–0.115] (pclose = 0.436) and CFI = 0.998). The CFA of the TAS indicated a good/acceptable fit (χ2/df = 422.31/132 = 3.2, TLI = 0.89, RMSEA = 0.07 [95% CI 0.063–0.078] (pclose < 0.001) and CFI = 0.91) (items 4 and 8 were removed due to low factor loading (< 0.4)). Being married and higher secure attachment style were significantly associated with more couple satisfaction, whereas older age, higher household crowding index, more alexithymia and mode depression were significantly associated with less couple satisfaction. In addition, alexithymia mediated the association between secure attachment style and couple satisfaction, between preoccupied attachment style and couple satisfaction and between dismissing attachment style and couple satisfaction.

Conclusion
Couple’s satisfaction is positively associated with secure attachment style. In addition, alexithymia plays a mediating role between couple’s satisfaction and attachment styles. Upcoming studies should determine if other mental illnesses play a mediating role between attachment style and couple satisfaction.
Carbon nanotubes in the holding solution stimulate flower opening and prolong vase life in carnation
Authors: Ahmadi-Majd Masoumeh , Mousavi-Fard Sadegh , Rezaei Nejad Abdolhossein , Fanourakis Dimitrios 
Published: January 2022

Abstract
Background
Cut flower longevity is often limited by adverse water relations or oxidative stress. The potential of single- and multi-walled carbon nanotubes (SWCNTs and MWCNTs, respectively) on prolonging vase life was addressed. Dose–response curves were obtained by applying five concentrations (0–80 mg L−1) of SWCNTs or MWCNTs either once as a foliar spray or continuously in the holding solution of three carnation cultivars. Next, the optimal concentration of either SWCNTs or MWCNTs was employed to evaluate several parameters critical for vase life.

Results
Foliar spray application exerted minor effects on water relations, flower opening and keeping quality. By contrast, including CNTs in the holding solution sustained a positive water balance for a longer period, improved flower opening and prolonged vase life. These effects were similar between SWCNTs and MWCNTs, and were concentration-dependent. The optimal concentration for vase life was higher for MWCNTs as compared to SWCNTs, and for two cultivars as compared to the third one. At optimal concentration, SWCNTs or MWCNTs in the holding solution generally maintained turgidity, and alleviated chlorophyll degradation, electrolyte leakage and lipid peroxidation. These effects were related to increased activation of enzymatic (ascorbate peroxidase, catalase, peroxidase and superoxide dismutase) and non-enzymatic (carotenoids, polyphenols, and flavonoids) antioxidants.

Conclusion
CNTs in the holding solution were very effective in stimulating vase life through improved water relations and enhanced antioxidant machinery stimulation.

Graphical Abstract
Evidence-based uncertainty estimates for the International Geomagnetic Reference Field
Authors: Beggan Ciarán D. 
Published: January 2022

AbstractThe International Geomagnetic Reference Field (IGRF) is a multi-institute model of the Earth’s magnetic field, compactly described by sets of up to 195 spherical harmonic (Gauss) coefficients to degree and order 13, which allows the continuous evaluation of the field at any location and time on or above the surface. It is developed from satellite and ground-based magnetometer data and describes the large-scale variation of the magnetic field in space and time under quiet conditions. While much effort has been made on improving the forecast of the secular variation of the field over the 5-year intervals between release and renewal, less emphasis has been placed on understanding the spatial errors from a user point of view. In this study, we estimate the large-scale time-invariant spatial uncertainty of the IGRF based on the globally averaged misfit of the model to ground-based measurements at repeat stations and observatories between 1980 and 2021. As the ground measurements are reduced to quiet-time values, the external field is minimized for the purposes of this study. We find the 68.3% confidence interval is 87 nT in the North (X) component, 73 nT in the East (Y) component and 114 nT in vertical (Z) component. Due to the Laplacian distribution of the residuals, the standard deviations are larger at 144, 136 and 293 nT, respectively.
Graphical Abstract