bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-resolved velocity mapping at high magnetic fields: A preclinical comparison between stack‐of‐stars and cartesian 4D-Flow
Authors: Nahardani Ali , Krämer Martin , Ebrahimi Mahyasadat , Herrmann Karl-Heinz , Leistikow Simon , Linsen Lars , Moradi Sara , Reichenbach Jürgen R. , Hoerr Verena 
Published: September 2022

Purpose: Prospectively-gated Cartesian 4D-flow (referred to as Cartesian-4D-flow) imaging suffers from long TE and intensified flow-related intravoxel-dephasing especially in preclinical ultra-high field MRI. The ultra-short-echo (UTE) 4D-flow technique can resolve the signal loss in higher-order blood flows; however, the long scan time of the high resolution UTE-4D-flow is considered as a disadvantage for preclinical imaging. To compensate for prolonged acquisitions, an accelerated k0-navigated golden-angle center-out stack-of-stars 4D-flow sequence (referred to as SoS-4D-flow) was implemented at 9.4T and the results were compared to conventional Cartesian-4D-flow mapping in-vitro and in-vivo.Methods: The study was conducted in three steps (A) In-vitro evaluation in a static phantom: to quantify the background velocity bias. (B) In-vitro evaluation in a flowing water phantom: to investigate the effects of polar undersampling (US) on the measured velocities and to compare the spatial velocity profiles between both sequences. (C) In-vivo evaluations: 24 C57BL/6 mice were measured by SoS-4D-flow (n = 14) and Cartesian-4D-flow (n = 10). The peak systolic velocity in the ascending aorta and the background velocity in the anterior chest wall were analyzed for both techniques and were compared to each other.Results: According to the in-vitro analysis, the background velocity bias was significantly lower in SoS-4D-flow than in Cartesian-4D-flow (p &lt; 0.05). Polar US in SoS-4D-flow influenced neither the measured velocity values nor the spatial velocity profiles in comparison to Cartesian-4D-flow. The in-vivo analysis showed significantly higher diastolic velocities in Cartesian-4D-flow than in SoS-4D-flow (p &lt; 0.05). A systemic background bias was observed in the Cartesian velocity maps which influenced their streamline directions and magnitudes.Conclusion: The results of our study showed that at 9.4T SoS-4D-flow provided higher accuracy in slow flow imaging than Cartesian-4D-flow, while the same measurement time could be achieved.
Cardiac stroke volume in females and its correlation to blood volume and cardiac dimensions
Authors: Schierbauer Janis , Ficher Sandra , Zimmermann Paul , Wachsmuth Nadine B. , Schmidt Walter F. J. 
Published: September 2022

We aimed to continuously determine the stroke volume (SV) and blood volume (BV) during incremental exercise to evaluate the individual SV course and to correlate both variables across different exercise intensities. Twenty-six females with heterogeneous endurance capacities performed an incremental cycle ergometer test to continuously determine the oxygen uptake (V̇O2), cardiac output (Q̇) and changes in BV. Q̇ was determined by impedance cardiography and resting cardiac dimensions by 2D echocardiography. Hemoglobin mass and BV were determined using a carbon monoxide-rebreathing method. V̇O2max ranged from 32 to 62 mL·kg−1·min−1. Q̇max and SVmax ranged from 16.4 to 31.6 L·min−1 and 90–170 mL, respectively. The SV significantly increased from rest to 40% and from 40% to 80% V̇O2max. Changes in SV from rest to 40% V̇O2max were negatively (r = −0.40, p = 0.05), between 40% and 80% positively correlated with BV (r = 0.45, p &lt; 0.05). At each exercise intensity, the SV was significantly correlated with the BV and the cardiac dimensions, i.e., left ventricular muscle mass (LVMM) and end-diastolic diameter (LVEDD). The BV decreased by 280 ± 115 mL (5.7%, p = 0.001) until maximum exercise. We found no correlation between the changes in BV and the changes in SV between each exercise intensity. The hemoglobin concentration [Hb] increased by 0.8 ± 0.3 g·dL−1, the capillary oxygen saturation (ScO2) decreased by 4.0% (p &lt; 0.001). As a result, the calculated arterial oxygen content significantly increased (18.5 ± 1.0 vs. 18.9 ± 1.0 mL·dL−1, p = 0.001). A 1 L higher BV at V̇O2max was associated with a higher SVmax of 16.2 mL (r = 0.63, p &lt; 0.001) and Q̇max of 2.5 L·min−1 (r = 0.56, p &lt; 0.01). In conclusion, the SV strongly correlates with the cardiac dimensions, which might be the result of adaptations to an increased volume load. The positive effect of a high BV on SV is particularly noticeable at high and severe intensity exercise. The theoretically expected reduction in V̇O2max due to lower SV as a consequence of reduced BV is apparently compensated by the increased arterial oxygen content due to a higher [Hb].
A quantitative 3D intravital look at the juxtaglomerular renin-cell-niche reveals an individual intra/extraglomerular feedback system
Authors: Arndt Patrick , Sradnick Jan , Kroeger Hannah , Holtzhausen Stefan , Kessel Friederike , Gerlach Michael , Todorov Vladimir , Hugo Christian 
Published: September 2022

The juxtaglomerular niche occupied by renin cells (RCN) plays an important role in glomerular repair but the precise temporal and spatial interrelations remain unclear. This study proposes the hypothesis of a local intra-extraglomerular regenerative feedback system and establishes a new quantifiable system for RCN responses in individual glomeruli in vivo. A strictly intraglomerular two-photon laser-induced injury model was established. Labeled renin cells (RC) in transgenic renin reporter mice were fate-traced in healthy and injured glomeruli over several days by intravital microscopy and quantified via new three-dimensional image processing algorithms based on ray tracing. RC in healthy glomeruli demonstrated dynamic extraglomerular protrusions. Upon intraglomerular injury the corresponding RCN first increased in volume and then increased in area of dynamic migration up to threefold compared to their RCN. RC started migration reaching the site of injury within 3 hours and acquired a mesangial cell phenotype without losing physical RCN-contact. During intraglomerular repair only the corresponding RCN responded via stimulated neogenesis, a process of de novo differentiation of RC to replenish the RCN. Repeated continuous intravital microscopy provides a state-of-the-art tool to prove and further study the local intraglomerular RCN repair feedback system in individual glomeruli in vivo in a quantifiable manner.
Dance activity interventions targeting cognitive functioning in older adults with mild cognitive impairment: A meta-analysis
Authors: Yuan Yuxin , Li Xiaofen , Liu Wanxu 
Published: September 2022

ObjectivesTo comprehensively determine the effect of dance activities on the cognitive functions and its sub-domains of older adults with mild cognitive impairment (MCI).MethodsWe obtained data from PubMed, Web of Science, EBSCO, China national knowledge infrastructure, Wanfang data, and VIP databases from 2017/01/01 to 2022/03/01. We included trials of older adults with MCI that underwent dance activity intervention and fulfilled the inclusion criteria. Two researchers independently assessed the quality of the study using the Cochrane risk of the bias assessment tool. Meta-analysis was performed when data were available, with further subgroup analysis, using Review Manager 5.4, and sensitivity analysis was performed using Stata software 15.1.ResultsSearch terms yielded 183 articles, of which 12 fulfilled the inclusion criteria. This included 7 high-quality studies and 5 medium-quality studies. A total of 820 older adults were analyzed. Results showed that dance activity had beneficial effects for global cognition [SMDMMSE = 0.65, 95% CIMMSE (0.20, 1.09), pMMSE = 0.004; SMDMoCA = 0.87, 95% CIMoCA (0.44, 1.29), pMoCA &lt; 0.0001], memory [SMD = 0.61, 95% CI (0.35, 0.88), p &lt; 0.00001], visuospatial function [SMD = −0.39, 95% CI (−0.60, −0.19), p = 0.0002], cognitive flexibility [SMD = −0.31, 95% CI (−0.52, −0.11), p = 0.003], attention [SMD = 0.34, 95% CI (0.07, 0.61), p = 0.01], and balance [SMD = 1.25, 95% CI (0.06, 2.44), p = 0.04]. Further subgroup analysis showed that open-skill dance activity (OSDA) was more effective in promoting global cognition in older adults with MCI than closed-skill dance activity (CSDA) because of the different stimulation provided by the two types of dance activities in the brain regions of the older adults (p = 0.0002). It could be speculated that dance activity improved cognitive function mainly by affecting the microstructure and function of the cingulate tract, hippocampus, cardiovascular function, and other brain areas of older adults with MCI.ConclusionDance activities can significantly improve global cognition, memory, visuospatial function, cognitive flexibility, attention, and balance in older adults with MCI. However, more trials with rigorous study designs are necessary to provide more concrete evidence in the future.
Prevalence of prolonged grief disorder and its symptoms in Chinese parents who lost their only child: A systematic review and meta-analysis
Authors: Yuan Meng-Di , Wang Zong-Qin , Fei Lei , Zhong Bao-Liang 
Published: September 2022

BackgroundParents who lost their only child and cannot have a second child (“Shidu”) have been a large population in China. Prolonged grief disorder (PGD) in Shidu parents is of clinical and public health concern but the reported PGD prevalence varies widely. To facilitate the planning of grief counseling services, this meta-analysis estimated prevalence of PGD and its symptoms and identified subgroups at elevated risk for PGD.MethodsWe searched English and Chinese literature databases to identify cross-sectional surveys reporting prevalence of PGD or PGD symptoms in Chinese Shidu parents. The Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data (“JBI”) was used to assess risk of bias of included studies.ResultsSeven studies with a total of 2,794 Shidu parents were included and their JBI scores ranged from five to eight. The pooled prevalence of PGD and PGD symptoms was 20.9% and 75.0%, respectively. Greater risk of PGD was observed in mothers [vs. fathers, OR (odds ratio) = 1.89, P = 0.001] and in parents with religious beliefs (vs. without religious beliefs, OR = 1.65, P = 0.040). More severe PGD symptoms were presented in parents whose only child died from accidents [vs. illness, MD (mean difference) = 3.99, P &lt; 0.001]. Deceased children of PGD parents were older than those of non-PGD parents (MD = 1.64, P = 0.035) and PGD parents had a shorter duration since the loss than non-PGD parents (MD = −3.26, P = 0.013).ConclusionsPGD is prevalent among Shidu parents. Grief counseling services for Shidu parents would be more effective if they target those who are mothers and have religious beliefs and those whose children died from accidents, lost children are older, and loss occurs more recently.
Mental health impact of COVID-19 on Saudi families and children with special educational needs and disabilities in Saudi Arabia: A national perspective
Authors: Alenezi Shuliweeh , Temsah Mohamad-Hani , Alyahya Ahmed S. , Almadani Ahmad H. , Almarshedi Afnan , Algazlan Maha S. , Alnemary Faisal , Bashiri Fahad A. , Alkhawashki Samah Hazem , Altuwariqi Maram Hani , Alsedrani Rafif , Alkhiri Aqeel , Alarabi Mohammed 
Published: September 2022

IntroductionThe COVID-19 pandemic revealed a multidimensional impact on mental health due to health concerns, social distancing and lockdowns, job loss, and limits in institutional support. Accordingly, COVID-19 may disproportionally impact families with special educational needs and disabilities (SEND) due to the already high prevalence of mental health conditions in children with SEND and their parents. Hence, it is essential to determine the short-term impact of the pandemic on the mental health of families with SEND to identify their ongoing health, including psychological wellbeing and support needs. The current study examines the anxiety level and concerns of children with SEND and their parents living in Saudi Arabia.MethodologyA cross-sectional national study design was utilized as a part of an international consortium using an online Arabic survey. Data were collected from the Ministry of Human Resources and Social Development beneficiaries from May to July 2020. The sample consisted of 1,848 parents of children with SEND aged between 1 and 18 years (mean = 9.66; SD = 4.31). A descriptive and bivariant analysis is reported.ResultsParental worries on all those concerns when the pandemic started were significantly higher than before the pandemic, p &lt; 0.050. Parental-perceived general anxiety had risen significantly across time, p &lt; 0.001, and their perceived anxiety when the pandemic started exceeded their anxiety before the pandemic, p &lt; 0.001. The general anxiety of children with SEND had risen significantly across time (from before the pandemic to when it had started to during the pandemic), p &lt; 0.001. The children's general worries at the start of the pandemic had correlated significantly and positively with their anxiety, adaptive, maladaptive, and coping efficacies, and parental anxiety scores, p &lt; 0.010 each.ConclusionAnxiety levels were high in SEND and their caregivers before and during COVID-19. At the start of the pandemic, the anxiety, adaptive, maladaptive, coping efficacies, and parental anxiety scores of children with SEND were significantly and favorably correlated. These findings support the notion of SEND-specific anxiety and patterns of coping in SEND and their caregivers. The notion also attests to the institutional support required for this specifically vulnerable population during epidemics.
Physical activity before and during the COVID-19 pandemic in Vojvodina, Serbia
Authors: Obradović Jelena , Radulović Nikola , Cvijović Duško , Jurišić Mila Vukadinović 
Published: September 2022

BackgroundThe physical activity (PA) of the youth and adult population underwent changes during the last 2 years due to the coronavirus (COVID-19) pandemic, and all for the purpose of maintaining the health of the population. The purpose of this study was to estimate the levels of PA in the youth population and the adult population (young and old) during the COVID-19 pandemic in the territory of Vojvodina, Serbia, and to determine the differences between them, as well as to compare these results with the results before the pandemic.MethodsA total of 1,117 subjects (age 36.27 ± 15.08 years) from the territory of Vojvodina, Serbia, participated in the study. Subjects were recruited and assigned to one of the three groups according to their age: youth group (N = 395; age 18–24 years), young adults group (N = 347; from 25 to 44 years), and old adults group (N = 375; age 45–65 years). All participants in this study completed the International Physical Activity Questionnaire Short-Form between July and November 2021, during the fourth wave of the COVID-19 pandemic in Vojvodina, Serbia. The Kruskal–Wallis test and Dunn multiple comparison post-hoc method were used for statistical analyses.ResultsThe youth showed the highest result in total weekly energy expenditure (3,893.72 ± 2,010.01 MET-min/week) compared to young adults (2,528.20 ± 1,804.11 MET-min/week) and old adults (2,369.07 ± 2,084.95 MET-min/week) during the COVID-19 pandemic in Vojvodina, Serbia. In addition, adults (young and old) spent more time sitting than youth during the same period. Furthermore, the youth achieved greater results in levels of PA during the COVID-19 pandemic compared to the situation before the COVID-19 pandemic. However, adult populations achieved lower results during the COVID-19 pandemic than before the COVID-19 pandemic.ConclusionDuring the COVID-19 pandemic, the youth from Vojovida, Serbia, achieved greater results in PA levels than the adult populations. Based on that, we recommend that it is necessary to take steps toward increasing PA in the adult population, especially old adults.
Knowledge, Attitudes and Practice toward Antibiotic Use among Under and Post-Graduate Students at Yarmouk University in Jordan: A Descriptive Study
Authors: Matalqah Laila M. , Albals Dima , Radaideh Khaldoon M. , Al-Khateeb Hakam , Thabet Romany H. , Abu-Ismail Luai , Abunasser Mohammad 
Published: September 2022

Objective: Irrational and overzealous use of antibiotics in addition to multidrug resistance has increased at an alarming limits around the world. This study aimed to evaluate the knowledge and practices toward antibiotic use among students at Yarmouk University
Material and Method: A cross-sectional descriptive survey using a structured electronic version of valid questionnaire was distributed among participants. Google form was prepared based on available questionnaire in literature, revised by a group of academic pharmacist to validate the questionnaire. Test-retest was performed for a small group and cronbach alpha was calculated. The form was distributed randomly among under- and postgraduate students at Yarmouk University via their mails.
Results: A total of 1154 individuals who completed questionnaires were analyzed. The knowledge of antibiotic use and resistance was quite good; 72.7% reported correct responses with a mean score of 16 out of 22. High rates of antibiotic use were found with 92% of respondents used antibiotics in the past three months. Inappropriate practice toward antibiotic was common; 48% used it for incorrect indication (e.g., common cold, fever, and pain), 60% used for improper duration and 20% don’t take the correct doses.
Conclusions: Interventions on enhancing awareness and understanding of rational antimicrobial use are highly recommended by promoting expert-driven behavioural change, effective communication, education and training. Furthermore, law restriction on antibiotic dispensing should be introduced.
ANALYSIS OF MARKETING COMMUNICATION STRATEGY TO MAINTAIN THE CUSTOMER LOYALTY (Study case on Janji Jiwa Volume 667 Tomohon)
Authors: Lengkey Andre Bernhard Samuel 
Published: September 2022

The intention of this research is to analyse the marketing communication strategy that implemented by Janji Jiwa volume 667 in order to build and maintain the loyalty of the customers. This research is a qualitative research with descriptive characteristic. In this research the population is in form of social situation that consist of place, actors and activity that interacts in synergy. In this case the object is Janji jiwa volume 667 coffee shop. And the ample is in form of subject which are the people that are related with the marketing communication strategy of Janji Jiwa volume 667 owner, manager, and baristas until the customers. The data colection methid in this research are interview, observation and documentation, where the indicators of colected data are the marketing communication strategy that implemented by Janji Jiwa volume 667 which are Advertising, Sales promotion, Personal seling and word of mouth activity. And also the factors that supporting and the obstaclest in implementing marketing communication strategy. The result of this research indicate that the marketing communication strategy of Janji jiwa volume 667 is effective and accurate to attract target customer and succeed in maintaining the loyalty of the customers. The result is proven with the total amount of the customers that came to Janji jiwa volume 667 and bought the products that are provided and served in Janji Jiwa volume 667. Keywords : Marketing communication strategy, Customers Loyalty, promotion, Advertising, Sales promotion, Personal selling and word of mouth.
ANALISIS PERBANDINGAN KINERJA PEGAWAI ASN DAN THL PADA UPTD WILAYAH 1 DINAS PUPRD PROVINSI SULUT
Authors: Sagay Miguel Ignatius , Dotulong Lucky O.H , Lumintang Genita Gracia 
Published: September 2022

Abstrak: Kinerja merupakan salah satu faktor penentu keberhasilan organisasi dalam mencapai tujuannya. pegawai dengan karakteristik yang baik akan menjadikan pegawai tersebut lebih mudah dalam mengerjakan pekerjaannya sehingga kinerja yang dihasilkan menjadi optimal dan sangat baik pengaruhnya bagi organisasi. Tujuan penelitian ini adalah untuk mengetahui ada atau tidaknya perbedaan kinerja Kinerja Pegawai ASN dan THL Pada UPTD Wilayah 1 Dinas PUPRD Provinsi Sulut.. Populasi dalam penelitian ini adalah pegawai ASN dan THL pada UPTD wilayah 1 Dinas PUPRD Provinsi Sulut, yang berjumlah 44 orang, yaitu ASN 22 orang dan THL 22 orang. Jenis Penelitian ini menggunakan penelitian komparatif yang bertujuan untuk melihat perbedaan dari variabel yang akan diuji dengan menggunakan analisis uji beda (Independent Sample t-Test). Hasil penellitian menunjukkan bahwa tidak terdapat perbedaan kinerja pegawai ASN dan pegawai THL pada UPTD Wilayah 1 Dinas PUPRD Provinsi Sulawesi Utara. Kata Kunci: kinerja pegawai, ASN, THL
PENGARUH FASHION INVOLVEMENT, SALES PROMOTION DAN POSITIVE EMOTION TERHADAP IMPULSE BUYING PADA MATAHARI DEPARTEMENT STORE MEGAMALL MANADO
Authors: Sumampow Katoci Zella , Soepeno Djurwati , Raintung Michael Ch 
Published: September 2022

Dalam kegiatan belanja suatu produk, ada kebiasaan pembelian yang dilakukan konsumen yaitu pembelian yang tidak terencana atau impulse buying yang mendominasi perilaku pembelian di usaha ritel. Konsumen yang memiliki fashion involvement yang tinggi cenderung menganggap bahwa konsumsi akan fashion berhubungan erat dengan kepercayaan diri sehingga orang tersebut seringkali dimintai pendapat mengenai fashion dalam kelompoknya. Keinginan yang timbul dari benak konsumen akan suatu produk dan jasa terus berkembang dan upaya perusahaan memenangkan peluang tersebut adalah dengan mengefektifkan strategi pemasaran. Salah satu elemen komunikasi pemasaran yang banyak digunakan adalah promosi penjualan atau sales promotion. Emosi atau perasaan yang dialami seseorang dapat membawa dampak pada keinginan yang sangat besar untuk melakukan impulse buying. Tujuan penelitian ini adalah untuk mengetahui apakah fashion involvement, sales promotion, positive emotion berpengaruh positif secara parsial dan simultan terhadap Matahari Departement Store megamall Manado. Penelitian ini merupakan penelitian kuantitatif asosiatif dengan metode pengambilan sampel menggunakan purposive sampling. Hasil penelitian menunjukkan bahwa, secara parsial dan simultan fashion involvement, sales promotion, positive emotion berpengaruh secara positif terhadap Matahari Departement Store megamall Manado.