bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Hypoglycemia on Productivity Loss and Utility in Patients With Type 2 Diabetes Treated With Insulin in Real-world Canadian Practice: Protocol for a Prospective Study
Authors: Lambert-Obry Veronique , Lafrance Jean-Philippe , Savoie Michelle , Lachaine Jean 
Published: February 2022

Background
Type 2 diabetes mellitus (T2DM) imposes a substantial burden owing to its increasing prevalence and life-threatening complications. In patients who do not achieve glycemic targets with oral antidiabetic drugs, the initiation of insulin is recommended. However, a serious concern regarding insulin is drug-induced hypoglycemia. Hypoglycemia is known to affect quality of life and the use of health care resources. However, health economics and outcomes research (HEOR) data for economic modelling are limited, particularly regarding utility values and productivity losses.

Objective
This real-world prospective study aims to assess the impact of hypoglycemia on productivity and utility in insulin-treated adults with T2DM from Ontario and Quebec, Canada.

Methods
This noninterventional, multicenter, 3-month prospective study will recruit patients from 4 medical clinics and 2 endocrinology or diabetes clinics. Patients will be identified using appointment lists and enrolled through consecutive sampling during routinely scheduled consultations. To be eligible, patients must be aged ≥18 years, diagnosed with T2DM, and treated with insulin. Utility and productivity will be measured using the EQ-5D-5L questionnaire and Institute for Medical Technology Assessment Productivity Cost Questionnaire, respectively. Questionnaires will be completed 4, 8, and 12 weeks after recruitment. Generalized estimating equation models will be used to investigate productivity losses and utility decrements associated with incident hypoglycemic events while controlling for individual patient characteristics. A total of 500 patients will be enrolled to ensure the precision of HEOR estimates.

Results
This study is designed to fill a gap in the Canadian evidence on the impact of hypoglycemia on HEOR outcomes. More specifically, it will generate productivity and utility inputs for the economic modeling of T2DM.

Conclusions
Insulin therapy is expensive, and hypoglycemia is a significant component of economic evaluation. Robust HEOR data may help health technology assessment agencies in future reimbursement decision-making.

International Registered Report Identifier (IRRID)
PRR1-10.2196/35461
DIREITO ADMINISTRATIVO DISCIPLINAR EM TEMPOS DE INTERNET E REDES SOCIAIS
Authors: Schiavi Pablo 
Published: February 2022

O Direito Administrativo Disciplinar enfrenta enormes desafios nos tempos atuais. Por isso, nos referimos a um Direito Administrativo Disciplinar em tempos de Internet e redes sociais. O dever de reserva é talvez um dos deveres mais importantes dos funcionários públicos. Não há dúvidas sobre isso. E precisamente o dever de reserva adquire novas dimensões na medida em que a violação do mesmo é reforçada pelo impacto das novas tecnologias, da Internet e das redes sociais. O novo Estatuto da Função Pública no Uruguai impõe a avaliação de diferentes circunstâncias (o dever funcional violado, o grau em que foram violados os regulamentos aplicáveis, a gravidade dos danos causados e o descrédito da imagem pública da Administração). Para qualificar as faltas dos funcionários como leves, graves e gravíssimas, merecendo apenas a última, a sanção de demissão. O funcionário que torne público, divulgue ou dê conhecimento de documentos sigilosos a terceiros incorrerá em uma falta muito séria, sujeita a demissão. A permanente viralização de informações e conteúdos nas redes sociais impacta, sem dúvida, no momento da avaliação das referidas circunstâncias, na qualificação das faltas, na medida em que a cada dia é mais comum que uma violação obrigações funcionais venham a conhecimento público na Internet e nas diversas redes sociais. Essa situação não é expressamente contemplada em nossa lei positiva. O presente trabalho será dedicado a isso.
PLURALISMO JURÍDICO E CONTRA-HEGEMONIA DOS POVOS REMANESCENTES DE QUILOMBOS
Authors: Wolkmer Antonio Carlos , Lopes Júlio Cesar 
Published: February 2022

O presente texto tem como objeto apresentar uma breve discussão sobre alguns aspectos do Pluralismo Jurídico Insurgente envolvendo a contra-hegemonia dos povos remanescentes de quilombo. Assim, busca evidenciar dentre seus objetivos: (a) como se estabelece a normatividade insurgente, suas vertentes e seus caminhos; (b) demonstrar que desde a África até a atualidade o povo negro passa por constantes lutas contra um sistema de dominação. Nesse sentido, esta pesquisa busca responder ao seguinte questionamento sobre a possibilidade de compreender a pluralidade normativa insurgente como práxis constante e contra-hegemônica de cinco séculos dos povos negros. O método de abordagem utilizado foi o dedutivo e o de procedimento o monográfico, com a técnica de pesquisa bibliográfica, com ênfase a obras nacionais e estrangeiras. A discussão teórica e sua problematização compreenderá, estruturalmente, três momentos: o primeiro sobre o pluralismo jurídico de tipo insurgente, o segundo tratará da diáspora negra e o terceiro, é representada pela insurgência em contraposição aos colonizadores europeus desde a África. Os descendentes africanos experimentaram uma nova nomeação pelos colonizadores europeus intitulada negros. Referência a cor que trouxe separação e desnivelamento. A visão europeia que parte da perspectiva de sua história e cultura irradiou ao mundo a inferiorização e neutralização, cabendo a este povo desde a expansão colonizadora até o presente, resistir para resgatar e manter sua identidade, proteger suas comunidades e seus pares, em uma busca ininterrupta de emancipação.
STUDENTS’ PERCEPTION AND PREFERENCE TOWARDS OPEN AND DISTANCE LEARNING (ODL) DURING COVID-19 PANDEMIC: A CASE STUDY OF STUDIO-BASED LEARNING
Authors: Amir Atikah Fukaihah , Borhan Ruwaidah 
Published: February 2022

Open and Distance Learning (ODL) has been widely known to the academic institutions as one of the methods in teaching and learning since COVID-19 pandemic hit nationwide on December 2019. Since then, many educational institutions have started to consider conducting the classes through online platforms such as Google Meet, Cisco WebEx, Microsoft Teams and others. Design-based studio is one of the design stream classes, which practically uses studio classes physically to develop many creative design ideas, skills, innovation, solution, and is considered as the real value of design studio education. However, the studio classes were switched to online platform, and teaching and learning strategy needed to be modified to deal with this issue, dramatically. Thus, the aim of this study is to identify the most effective delivery method in teaching and learning for current best in educational practices. 14 sets of questions in Google Form questionnaire were distributed on week 14 to the students of Landscape Architecture. A total of 261 students responded out of 394 students enrolled in the Landscape Architecture Design studio. The students were in Semester 2, 4 and 6. The students were selected based on the large number of student’s enrollment. The results showed that the students enjoyed learning using Whatsapp, Google Meet and Google Classroom as a synergistic medium for critic sessions. The research suggests three stages of tutorial sessions to suit the needs of the student’s preference.
Communication architecture of power monitoring system based on incidence matrix model
Authors: Che Xiangbei , Li Man , Zhang Xu , Alassafi Madini O. , Zhang Hongbin 
Published: February 2022

Abstract
To ensure the stability of the communication architecture in the power monitoring system, we propose an intelligent grid cyber-physical communication architecture modelling method based on the correlation characteristic matrix model. The article connects the physical entity layer, the information physical coupling layer, and the information system layer through an incidence matrix to form a complete power information physical system unit model. Through this system, we call the link and each node on the call link as the monitoring object, collect the relevant index data, and establish the business alarm mapping model of the communication network failure. The experimental results verify the reliability of the system and algorithm.
Valuation of Rubber Waste and Dune Sand: mortar for construction and environmental protection
Authors: Aidoud Assia , Bencheick Messaouda , Boukour Salima 
Published: February 2022

Abstract
The main objective of this study is the recovery of dune sands and rubber waste (powders). The latter constitutes a potential source of several environmental and economic problems.
The objective of this present work is to examine the ability to use dune sand for the preparation of mortars with sufficient physico-mechanical properties to allow them to be used in various building construction applications. The formulation of the mixtures is based on replacing dune sand with powders, at different weight contents: 10 %, 20 %, and 30 %. The quantity of cement is set at 450 g. The results obtained show in the first place that the particle size of the mixture tends to be spread out with a remarkable increase in the fineness modulus, and in the second place the density of the mixture decreases by 6.5 % (for the apparent) and by 10 % (for the absolute), which means the calculation of loads for the resulting mortar must decrease. Porosity has decreased to 20 % and absorption has increased to 30%. The strengths have decreased over 40 % for compressive strength and over 30 % for tensile strength, with an improvement in the relationship between the two strengths.
Determinación de Salmonella spp. en expendios de quesillo y queso picado salado destinados para consumo humano en el Caquetá – Colombia
Authors: García Rincón Paola Andrea , Grajales-Zuleta Andrés A. , Rodríguez-Pérez Wilson , Ortega-Montealegre Madelyn D. , Guaracas-Gutiérrez Yesika A. 
Published: February 2022

El departamento del Caquetá cuenta con una producción lechera gracias al cruce de razas B. Taurus (Europea) con B. Indicus (Cebú); por tal motivo la producción y comercialización de queso y quesillo son la principal actividad agroindustrial, sin embargo, con muchas deficiencias en controles sanitarios. El objetivo de este estudio fue realizar un Diagnóstico higiénico sanitario de los expendios de queso en la ciudad de Florencia Caquetá, y determinar la prevalencia Salmonella spp en uno de los principales productos del departamento; el Quesillo y Queso Picado Salado, productos protegidos con denominación de origen otorgada por la Superintendencia de industria y comercio de Colombia. Para el desarrollo del estudio se visitaron todos los expendios de quesos de la ciudad, se aplicó el acta de inspección sanitaria para evaluar las condiciones de Buenas Prácticas de Manufactura (BPM) y se tomaron 28 muestras de los productos las cuales analizaron mediante el método horizontal ISO 6579:2002 para determinación de Salmonella spp. Se calculó el cumplimiento global de BPM de los expendios de queso de la ciudad con el 52% evidenciado en graves incumplimientos sanitarios relacionados a la inadecuada manipulación del alimento, equipos en mal estado y falencias en el almacenamiento como en la cadena de frío; con respecto a la Salmonella spp, 6 muestras resultaron con presencia del microorganismo en 5 establecimientos evaluados; el 20% de los expendios de queso cumplieron con los requisitos para un concepto sanitario favorable y el índice de prevalencia de la Salmonella spp fue del 33, 33%, lo cual podría afectar gravemente la salud de los consumidores de este producto y generar un problema de salud pública.
ЭКОНОМИЧЕСКАЯ ЭФФЕКТИВНОСТЬ РЕЖИМА ОРОШЕНИЯ И СРОКОВ ВНЕСЕНИЯ УДОБРЕНИЙ ХЛОПЧАТНИКА ПРИ УСОВЕРШЕНСТВОВАННОЙ ТЕХНОЛОГИИ ОБРАБОТКИ ПОЧВЫ
Authors: Абдурахмонов И.А. , Жанибеков Д.А. 
Published: February 2022

В итоге исследования определена что, в технологигии комбинационной не следует внесение в почву всей годовой нормы аммиака в борозды между грядками обрабатки почвы под хлопчатник а лучше внесения 50% в виде аммиака годовой нормы азота осенью.
As a result of the study, it was determined that, in combination technology, the introduction of the entire annual ammonia rate into the furrows between the beds in the soil tillage for cotton should not be introduced into the soil, and it is better to introduce 50% in the form of ammonia to the annual nitrogen rate in autumn.
ВЛИЯНИЕ СИДЕРАТОВ НА ЭЛЕМЕНТЫ ПЛОДОРОДИЯ ПОЧВЫ НА ПОСАДКАХ КАРТОФЕЛЯ
Authors: Остонакулов Т.Э. , Усмонов Н.Н. 
Published: February 2022

В условиях староорошаемых типичных сероземных почв Кашкадарьинской области были изучены агрофизические, водные свойства, пищевой режим почвы после сидератных культур. Выявленны лучшие сидераты оказывающие положительное влияние на плодородие почвы и посадках картофеля.
In the conditions of old-irrigated typical gray-earth soils of Kashkadarya region, the agrophysical, water properties, and nutrient regime of the soill after siderate crops were studied for the fi rst time. The best siderates have been identifi ed that have a positive effect on soil fertility and potato planting.
MAPPING OF GEOSYSTEM AND AGROLANDSCAPE RESEARCHES IN THE SOUTH OF CENTRAL SIBERIA
Authors: Лысанова Г.И. , Семенов Ю.М. , Сороковой А.А. , Балязин И.В. 
Published: February 2022

В статье рассмотрены результаты картографирования геосистем южных районов Средней Сибири в масштабе 1:1000000. Приведен фрагмент карты геосистем, описана ландшафтная структура территории. Выделено и охарактеризовано более 200 групп фаций, объединенных в 42 класса фаций, 13 групп геомов. На основе материалов ландшафтного картографирования, проведены агроландшафтные исследования. Применен ландшафтный подход в изучении агроприродного потенциала геосистем Минусинской котловины. Проанализирован и оценен агроприродный потенциал геосистем исследуемого региона.
The article discusses the results of mapping of geosystems in the southern regions of Central Siberia in the 1: 1000000 method. A fragment of the geosystem map is presented, and the landscape structure of the territory is described. More than 200 groups of facies united in 42 classes of facies and 13 groups of geomes were identifi ed and characterized. Based on the materials of landscape mapping, agrolandscape studies were carried out. A landscape approach has been applied in studying the agri-natural potential of the geosystems of the Minusinsk depression. The agri-natural potential of the geosystems of the studied region is analyzed and evaluated.
FUNDAMENTAL AND APPLIED ASPECTS OF USING SYSTEMS BIOLOGY
Authors: Чередниченко М.Ю. , Доброногова А.С. , Поливанова О.Б. , Хлебникова Д.А. , Сосина А.В. 
Published: February 2022

Рассмотрена концепция системной биологии, а также ее приложение в сфере фундаментальных исследований, медицины, фармацевтики, сельского хозяйства. Расширено понятие системной биологии за пределы омиксных технологий. Приведены примеры из зарубежной и отечественной практики, иллюстрирующие различные направления работы системных биологов.
The concept of systems biology, as well as its application in the fi eld of fundamental research, medicine, pharmaceuticals, agriculture, is considered. The concept of systems biology is expanded beyond the scope of omics. Examples from foreign and domestic practice illustrating various areas of work of system biologists are given.
ENVIRONMENTAL ASPECTS OF THE IMPLEMENTATION OF OIL PRODUCTION WASTES IN ORDER TO EXPAND THE RESOURCES OF OIL RAW MATERIALS
Authors: Елашева О.М. , Баландин Л.Н. , Трошина О.С. 
Published: February 2022

Исследование состава свойств асфальто-смолистых отложений АСПО различных месторождений России. Определено содержание АСПО и парафинов. Излечение и переработка АСПО расширяет ресурсы сырья и улучшает экологическую обстановку в нефтяных регионах.
A study of the composition of the properties of asphalt-resinous sediments of paraffi n deposits of various deposits in Russia. The content of paraffi n and paraffi n wax was determined. The treatment and processing of paraffi n deposits increases the resources of raw materials and improves the environmental situation in the oil regions.
INFLUENCE OF SOIL AND AIR MOISTURE ON THE DECORATIVE NATURE OF LAWN GRASS
Authors: Петрова Т.И. , Тазина С.В. , Тазин И.И. 
Published: February 2022

Данная статья посвящена влиянию почвенной и воздушной засухи на декоративность газонных трав. Литературные данные по засухоустойчивости газонных трав противоречивы. Это является важным особенно в условиях интенсивной газонной культуры, когда скашивания ниже 5 см, которые приводят к отмиранию побегов. При оценке газонов высшим критерием их устойчивости против любых неблагоприятных воздействий, в том числе и к засухе является декоративность. Декоративность газона является комплексным, обобщающим показателем, учитывающим множество факторов: интенсивности окраски и ширины листовой пластинки, густоты травостоя и его вариабельности по высоте и плотности. Сроки появления всходов и длительность вегетации также влияют на декоративность газона. При медленном появлении всходов и малом вегетационном периоде высеянного образца газон долгое время является недекоративным. Также декоративность образцов снижается в разной степени в зависимости от вида и сорта при поражениях ржавчиной, мучнистой росой, при вымерзании (полном или частичном). Поэтому определение в динамике в течение вегетационного периода, а также при скашивании газона за ряд лет испытаний позволяет достаточно точно установить уровень декоративности. По нашим данным, к одной группе по засухоустойчивости относятся: мятлик луговой, овсяницу красную, мятлик узколистный, сплюснутый, овсяницу луговую, овечью, разнолистную, райграс пастбищный, костёр безостый, житняк гребневидный, и некоторые формы полевицы тонкой.
This article is devoted to the infl uence of soil and air drought on the decorative lawn grass. The literature data on drought resistance of lawn grasses are contradictory. This is important especially in conditions of intense lawn culture, when mowing below 5 cm, which lead to the withering away of shoots. When assessing lawns the highest criterion of their resistance against any adverse effects, including drought is decorative. Decorative lawn is a complex, generalizing indicator that takes into account many factors: the intensity of the color and width of the leaf blade, the density of the grass stand and its variability in height and density. The timing of emergence and the duration of vegetation also affect the decorative lawn. With the slow emergence of seedlings and a small growing season of the sown sample, the lawn is non-decorative for a long time. Also decorative samples reduced to varying degrees depending on the type and variety in the lesions of rust, powdery mildew, freezing (full or partial). Therefore, the determination of the dynamics during the growing season, as well as mowing the lawn for a number of years of testing allows you to accurately determine the level of decorative. According to our data, one group for drought resistance are: Kentucky bluegrass, red fescue, PoA angustifolia, fl attened, meadow fescue, sheep’s, heterophyllous, perennial ryegrass, brome grass, Wheatgrass comb, and some form of bent grass fine.
ОЦЕНКА ЗАКРИТИЧЕСКОГО ПОВЕДЕНИЯ ПОВЕРХНОСТНОГО КРАЕВОГО РАССЛОЕНИЯ АНИЗОТРОПНОЙ СТРУКТУРЫ ПРИ СЖАТИИ КОМПОЗИТНОЙ ПАНЕЛИ С УЧЕТОМ НАЧАЛЬНОЙ ПОГИБИ
Authors: Митрофанов О.В. 
Published: February 2022

Получено аналитическое решение геометрически нелинейной задачи для прямоугольной панели анизотропной структуры с учетом начальной погиби при граничных условиях соответствующих жесткому опиранию по одной длинной стороне и свободному опиранию по длинной стороне. Предложена прикладная методика оценки закритического поведения поверхностного дефекта анизотропной структуры при сжатии.
An analytical solution of a geometrically nonlinear problem for a rectangular panel of an anisotropic structure is obtained, taking into account the initial loss under boundary conditions corresponding to a rigid support on one long side and a free support on the long side. An applied method for evaluating the post-buckling behavior of a surface defect of an anisotropic structure under compression is proposed
РЕЗУЛЬТАТЫ ФАЗОВОГО РАВНОВЕСИЯ СИСТЕМЫ Na2O(Na2CО3) – Na2CrO4
Authors: Байсангурова А.А. , Магомадова М.А. , Ильхаева З.С. 
Published: February 2022

Впервые методами термического анализа экспериментально изучены фазовые комплексы системы Na2O(Na2СО3) – Na2CrO4. Построены завершенные топологические модели их фазовых диаграмм, сочетание которых позволило объяснить особенности процессов фазообразования, характеризующихся как эвтектические и перитектические.
For the fi rst time, phase complexes of the Na2O(Na2СО3) – Na2CrO4 system were experimentally studied by thermal analysis methods. Completed topological models of their phase diagrams are constructed, the combination of which made it possible to explain the features of the phase formation processes, which are characterized as eutectic and peritectic.
ПРОТИВОРАКОВЫЕ, АНТИОКСИДАНТНЫЕ И АНТИДИАБЕТИЧЕСКИЕ СВОЙСТВА РАСТЕНИЙ РОДА ZINGIBER SP.
Authors: Иванова Л.А. , Чурмасова Л.А. , Фоменко И.А. , Фоменко В.В. , Кузьмичева Т.П. , Константинова Н.А. 
Published: February 2022

На основе изученной литературы были рассмотрены фармакологические свойства наиболее перспективных для дальнейшего изучения вторичных метаболитов растений рода Zingiber sp.: гингеролов и шагаолов, такие как противораковая, антиоксидантная и антидиабетическая активности. Описаны способы их выявления, а также их влияние на химико-биологические процессы различных организмов.
Based on the literature studied, the most important pharmacological properties of the most promising for further study of secondary metabolites of plants of the genus Zingiber sp.: gingerols and shogaols, such as anti-cancer, antioxidant and antidiabetic, were considered. Ways to identify them, as well as their effect on the chemical and biological processes of various organisms, have been described.
ВЛИЯНИЕ ИНВАЗИИ ОПИСТОРХОЗОМНА ИЗМЕНЕНИЕ РЕАКТИВНОСТИ СЕРДЕЧНО-СОСУДИСТОЙСИСТЕМЫ К НОРАДРЕНАЛИНУ И АЦЕТИЛХОЛИНУПРИ ХОЛОДОВОЙ АДАПТАЦИИ
Authors: Ананьев В.Н. , Прокопьев Н.Я. , Бычков В.Г , Ананьева О.В. , Гуртовой Е.С. , Ананьев Г.В. 
Published: February 2022

В работе проведен анализ адренореактивности и холинореактивности системного кровообращения кроликов на 30-й день холодовой адаптации по сравнению с кроликами с 90-суточным экспериментальным описторхозом. Из данных опытов мы можем сделать обоснованное заключение, что инвазия описторхозом способствует выживанию организма при воздействии холода.
In work the analysis adrenoreactance and cholinoreactance of system blood circulation of rabbits for 30th day cold adaptations in comparison with rabbits with 90-daily allowances experimental opisthorchiasis is carried out. We can make the proved conclusion Of the given experiences, that infection opisthorchiasis promotes an organism survival at cold infl uence.
ПРОЕКТИВНОЕ ПОКРЫТИЕ ИСКУССТВЕННЫХ РАСТИТЕЛЬНЫХ СООБЩЕСТВ С РАЗЛИЧНЫМ СОСТАВОМ В АГРОЭКОСИСТЕМАХ С РАЗВИТИЕМ ЛИНЕЙНОЙ ЭРОЗИИ
Authors: Ланин Д.О. , Маринич М.Н. , Виноходов А.С. , Коцарева Н.В. 
Published: February 2022

Разработаны и изучены травосмеси злаковых и бобовых трав для создания устойчивых искусственных растительных сообществ на водотоках в условиях интенсивного развития линейной эрозии почв в степной и лесостепной зонах Белгородской области. Во всех вариантах опыта проективное покрытие на залужаемых водотоках в степной зоне сохранялось в среднем на уровне 83,4%, в лесостепной зоне – 86,25%, что значительно снижало интенсивность поверхностного стока.
Grass mixtures of cereals and legumes have been developed and studied to create stable plant communities on water courses under conditions of intensive development of linear soil erosion in the steppe and forest-steppe zones of the Belgorod Region. In all variants of the experiment, for 3 years the projective cover on the tinned streams in the steppe zone remained on average at the level of 83.4%, in the forest-steppe zone – 86.25%, which signifi cantly reduced the intensity of surface runoff.