bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pan-cancer analysis of ARMCX genes identifies ARMCX1 as a novel suppressor gene for pancreatic carcinoma
Authors: Shen Bingbing , Xu Jian , Quan Gang , Wang Jianguo , Liu Yunxun , Jiang Jianxin 
Published: September 2022

Abstract
Background:
Pancreatic carcinoma (PAAD) is one of the malignant tumors with high lethality and low survival rate. Armadillo (ARMCX) family members play vital roles in tumorigenesis, but the tumorigenesis was not unclear. Our study aims to explore the novel biomarker of early diagnosis, treatment, and prognosis for PAAD.
Methods:
Firstly, UCSC Xena was used to download the data of pan-cancer. Then, we perform the pan-cancer analysis of ARMCX genes from expression, survival, immune subtype, tumor microenvironment, and stemness. Secondly, we focus on the roles of ARMCX genes in PAAD from the immune subtype, tumor microenvironment, and stemness. Lastly, we used GEIPA to select a key gene, and ARMCX1 was selected as our object. We analyzed the roles of ARMCX1 in PAAD from the differential expression, survival, independent prognosis, clinical features, mechanism, DNA methylation levels, immune cell infiltration, and immunoinhabitors.
Results:
Based on the pan-cancer analysis, we deem that the differential expression of ARMCX genes exists in multiple tumors, which is closely associated with OS of multiple tumor patients. Plus, we also found that the expression is negatively related to immune subtypes, estimate score, immune score, stromal score, and stemness score. Based on the PAAD analysis, we found that the expression of ARMCX1 and ARMCX4 was significantly different in the immune subtype and a significant difference exists in RNAss, DNAss, stromal score, immune score, and estimate score. Based on the study of ARMCX1 in PAAD, We deemed that ARMCX1 is a lower expression in PAAD than in normal pancreas tissue, and the low expression is closely associated with poor OS of PAAD patients. ARMCX1 is an independent prognosis factor for PAAD patients. In addition, the downregulation of ARMCX1 is also closely associated with hypermethylation of the ARMCX1 promoter. We also found that the expression of ARMCX1 is related to some immune cells and immunoinhibitors.
Conclusion:
Therefore, we concluded that hypermethylation of the ARMCX1 promoter leads to the downregulation of ARMCX1 expression and inhabits the PAAD progression through influencing the immune cell by some potential mechanism.
Investigation of Factors Affecting Motif-Based Short- and Long-Term Memory Behaviour in Biological Networks
Authors: TURAN AHMET , KAYIKÇIOĞLU Temel 
Published: September 2022

Abstract
Learning and memory formation in living organisms is an issue under investigation. How learning occurs is not fully understood. Nevertheless, learning and memory are evaluated to correlate with the connective structure between cells. Memory formed in the biological neural network structure is thought to be closely related to cell connections. Biological experiments have been determined connections called motifs, which usually comprise three or four cells and repeat within the network. The connection of these motifs varies as to the status of inter-cellular stimulus. The primary make-up of the biological memory is thought to correlate with such repeated cell connections. For this reason, studies investigate the memory behaviour of the motifs. In this study, some important factors affecting motif-based short- and long-term memory behaviour in biological networks were investigated. For that purpose, the effect of the connection patterns of the motifs on the short- and long-term memory structure was investigated for all three-cell motifs. We used the Hodgkin-Huxley neuron model for cells. Using graph theory, we created three-cell motifs. In the created motifs; The effects of intercellular connection patterns, the type of excitation of cells to each other, and the duration of chemical synaptic stimulation on short- and long-term memory were examined. Based on the data got from the models; We showed that the structure of the motif and the type of stimulus affect directly memory formation in all three-cell motifs. We also showed that the short-term memory duration (in the motif and stimulation conditions) changes with the change of the synaptic stimulation time constant, which models the duration of intercellular communication. At the end of this study, we classified all three-cell motifs for the states that present short- and long-term memory behaviour. We studied the biological events that occur during learning on the model and examined their effects on learning. Consequently, these studies have demonstrated learning about living organisms.
OMM: Online Mobile Mindfulness to Improve the Well-Being of Cancer Survivors
Authors: Orasud Ariel Siritorn , Bantum Erin , Uchiyama Mai 
Published: September 2022

Abstract
Purpose: Anxiety and cancer related neuropathy are two persistent effects related to treatment for cancer. Mindfulness meditation has been used with substantial impact as a non-pharmacologic intervention to mitigate side and late effects of treatment. Mobile apps are ubiquitous for most of the general population, yet have a particular relevance for cancer survivors, given that physical and geographic limitations can be present. The goal of the current manuscript is to describe an ongoing trial of the Mindfulness Coach mobile application (“app”) for cancer survivors.
Methods: In this randomized wait-list controlled trial, cancer survivors experiencing anxiety or cancer related neuropathy (200 in each arm) and who have finished primary treatment for cancer are invited to participate. Data are collected at three time points regardless of randomization condition: baseline, 8 weeks, and 16 weeks. Both face-to-face and online recruitment strategies have been employed. In addition to evaluating the impact of mobile mindfulness of anxiety or cancer related neuropathy, other pain, fatigue, trauma, sleep, and satisfaction with the Mindfulness Coach app will also be assessed.
Conclusion: Mindfulness meditation is becoming widely used by the general public, in addition to the use of mobile technology. Finding ways to deliver mindfulness meditation to people who have been treated for cancer allows for the intervention to be accessible to a larger breadth of survivors. The results of this intervention will have implications for further understanding the impact of mindfulness meditation on two persistent side and late effects of treatment of cancer— anxiety and cancer related neuropathy.
Primary ID: BANTUM-2017-1
Secondary ID: NCI-2019-08685
ClinicalTrials.gov ID: NCT03581357
Acceptable but further revision needed? The psychometric properties of the Positive Beliefs about Rumination Scale and the Negative Beliefs about Rumination Scale in relation to Chinese undergraduates
Authors: Zhou Honggui , Liu Hong , Ma Xiaohong , Deng Yunlong 
Published: September 2022

Abstract
Background
Rumination, a transdiagnostic factor in different psychopathological conditions, is believed to be activated and sustained by dysfunctional metacognition. The Positive Beliefs about Rumination Scale (PBRS) and the Negative Beliefs about Rumination Scale (NBRS) have been used to measure the metacognitive beliefs of rumination and have been investigated in many cultural contexts. However, it remains unclear whether these scales can work as well for the Chinese population. Therefore, this study aimed to explore the psychometric properties of the Chinese versions of these scales and to test the metacognitive model of rumination for students with different levels of depression.
Methods
The PBRS and NBRS were forward-backward translated into Mandarin. In total 1,025 college students were recruited to complete a battery of web-based questionnaires. Exploratory factor analysis, confirmatory factor analysis, and correlation analysis were used to test the structure, validity, and reliability of the two scales, as well as their item correlations with rumination.
Results
A new two-factor structure of the PBRS (rather than the original one-factor model) and a new three-factor structure of the NBRS (rather than the original two-factor model) were extracted. The goodness-of-fit indices of these two factor models showed they had a good to very good fit with the data. The internal consistency and construct validity of PBRS and NBRS were also affirmed.
Conclusion
The Chinese versions of the PBRS and the NBRS were generally shown to be reliable and valid, but their newly extracted structures fit the Chinese college students better than their original structures. These new models of PBRS and NBRS are of value to be further explored in Chinese population.
An extended Markov-switching model approach to modelling latent heterogeneity in departmentalized manpower systems
Authors: Ossai Everestus Okafor , Nduka Uchenna Chinedu , Madukaife Mbanefo Solomon , Udom Akaninyene Udo , Ugwu Samson Offorma 
Published: September 2022

Abstract
In recent works in manpower planning interest has been awakened in modelling manpower systems in departmentalized framework. This, as a form of disaggregation, may solve the problem of observable heterogeneity but not latent heterogeneity; it rather opens up other aspects of latent heterogeneity hitherto unaccounted for in classical (non-departmentalized) manpower models. In this paper a multinomial Markov-switching model is formulated for investigating latent heterogeneity in intra-departmental and interdepartmental transitions in departmentalized manpower systems. The model incorporates the mover-mediocre-stayer principle. The use of EM algorithm for estimation of the model parameters and a validity test for assessing the model performance in comparison to the classical Markov manpower model are presented.
Construction of the structural equation model of stigma, self-disclosure, social support, and quality of life of breast cancer patients after surgery——A multicenter study
Authors: Bu Liuxiu , Chen Xisui , Zheng Shaoyan , Fan Guanhua 
Published: September 2022

Abstract
Purpose: Stigma is common in patients with breast cancer after surgery, which has a negative impact on the quality of life(QOL). This study aimed to investigate the QOL of breast cancer patients after surgery and to analyze the multiple chains mediating effects of self-disclosure and social support between stigma and QOL.
Methods: A total 292 patients of breast cancer patients after operation were recruited in this study. A questionnaire survey was conducted using the general information questionnaire, the consumer experiences of stigma questionnaire (CESQ), the distress disclosure index(DDI), the perceived social support scale(PSSS), and the functional assessment of cancer therapy-breast(FACT-B). Path analysis was conducted to test the hypothesized serial multiple mediation model.
Results: The total scores of stigma, self-disclosure, social support and QOL were 15 (10 ~ 22), 39 (31 ~ 46), 58 (50 ~ 67) and 88 (74 ~ 104) respectively. QOL of breast cancer patients after the operation was negatively correlated with stigma (p < 0.01), and positively correlated with self-disclosure and social support (p < 0.01). Self-disclosure and social support played a complete mediating effect between stigma and QOL, and the total mediating effect value was 85. 87%.
Conclusions: Self-disclosure and social support play a complete intermediary role between stigma and QOL. In order to improve the quality of life of patients, medical staff should pay attention to the assessment of stigma, encourage patients to express their emotions, and encourage their families and friends to respond to their expression and needs of patients.
P4HA3 Promotes Clear Cell Renal Cell Carcinoma Progression via the PI3K/AKT/GSK3β Pathway
Authors: Zhang Zhechuan , Zhang Ronggui , Zhang Yuanfeng 
Published: September 2022

Abstract
Purpose
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma. P4HA3 is a key enzyme in collagen biosynthesis and has emerged as important molecules in regulation of proliferation, invasion, and metastasis in various tumor types. The role of P4HA3 in the development of ccRCC has remained to be elucidated.
Methods
Genes expression, prognostic, and enrichment analyses were carried out with bioinformatics analysis. The efficiency of P4HA3 knockdown was confirmed by real-time quantitative PCR and western blotting. The cellular functions were analyzed by CCK-8, EdU, wound healing, and transwell assays. The levels of related proteins expression were analyzed by western blotting.
Results
P4HA3 was highly expressed in ccRCC compared with normal tissue samples from the TCGA database. Kaplan-Meier curves results showed that the expression level of P4HA3 was significantly negatively correlated with overall survival of patients. P4HA3 expression knockdown inhibited the proliferation, migration, and invasion of ccRCC cells, as demonstrated by in vitro experiments. In addition, GSEA results revealed that P4HA3 may be related to EMT and involved in the PI3K-AKT-GSK3β pathway in ccRCC; this was tentatively confirmed through western blotting.
Conclusion
P4HA3 may induce ccRCC progression via the PI3K-AKT-GSK3β signaling pathway and could represent a potential therapeutic target.
Fuzzy-based variable impedance control of uncertain robot manipulator in flexible environment: A nonlinear force contact model-based approach
Authors: Guo Ying , Peng Jinzhu , Ding Shuai , Liang Jing , Wang Yaonan 
Published: September 2022

Abstract
In this paper, a variable impedance control method is proposed for uncertain robotic systems based on a nonlinear force contact-based flexible environmental model. First, a nonlinear force contact model between the rigid manipulator and flexible environment is established to approximate more realistic interaction responses and to avoid excessive overshoot of the force that usually exists in the traditional spring-damping environmental model. Then, according to the force contact-based environmental model, a fuzzy-based adaptive variable impedance controller is designed to achieve position and force tracking of the manipulator, where the impedance parameters are adjusted online through the force and position feedback of the robotic system, and the fuzzy logic system $(FLS)$ is used to compensate the uncertainties. The stability of adaptive variable impedance control is proved by Routh stability criterion and the boundness of all signals in the robotic system is proved by Lyapunov stability analysis. Finally, the effectiveness of the proposed method is verified by the simulation of a two-link manipulator.
A novel cysteine-based flame retardant for biomass poplar wood density board
Authors: Yan Dong , Chen Dong , Tan Jia , Yuan Liping , Huang Zizhi , Zou Dongfang , Peng Dongmei , Song Ling , Tao Qiang , Tan zhengde , Deng Jiyong , Hu Yunchu 
Published: September 2022

Abstract
A novel reactive flame retardant based on L-cysteines containing P, N and S flame retardant elements was synthesized and used to improve the flame resistance of a density board made of poplar wood. The outcomes demonstrated the excellent flame retardancy and catalytic carbon formation of the poplar density board treated with the flame retardant. The thermogravimetric infrared coupler (TG-FTIR) test and thermal cracking gas mass spectrometer (Py-GC-MS) test both revealed that the flame retardant modified the thermal decomposition pathway of the wood, forming many residues and producing only a small amount of combustible gas. The ultimate oxygen index (LOI) of poplar density board treated with 20% cysteine-based flame retardant was as high as 60.9%. Scanning electron microscopy (SEM) images revealed that the surface of the treated wood powder was rough and that the wood powder particles were interconnected by the flame retardant. This suggests that the flame-retardant molecules have a bridging effect on the inner structure of the density board. Moreover, the cone calorimetry (CONE) experiments showed that with the flame retardant treatment, there was significant reduction of total heat release (THR) and heat release rate (HRR) of the density board. These findings demonstrate the effectiveness of the cysteine-based flame retardant.
Cysteine-modified copper oxide nanoparticle doped in polysulfone ultrafiltration membrane for protein removal and treatment of poultry wastewater
Authors: Hasbullah Hasrinah , Sabri Nurul Shahira Mohd , Hamdan Jasmine , Lau WJ , Sadikin Aziatul Niza , Ibrahim Norazana , Rahman Sunarti Abd 
Published: September 2022

Abstract
Discharge of wastewater with high organic materials demands a significant development of polymeric ultrafiltration membrane for efficient treatment. Among the various nanomaterials used as additives in the polymeric membrane, copper oxide nanoparticles (CuO NPs) were particularly notable. The nanoparticles are available at an inexpensive cost, with vast surface area and ease of surface functionalization. However, the nanoparticle tends to agglomerate in the polymeric membrane due to the high surface activity of particles with smaller sizes. Surface modification of CuO NPs using amino acid L-cysteine as a stabilizer can overcome this problem. In this work, the surface modification process undergoes ultrasonication to create covalent anchoring at different ratios of L-cysteine to CuO NPs. Preparation of dope solution involves the addition of 18.0 wt.% polysulfone (PSf) and 5 wt.% polyvinylpyrrolidone (PVP). Then, the fabrication of the flat sheet membranes employs an immersion precipitation process. The TEM and FTIR analysis confirmed the presence of modified CuO NPs. Investigation using SEM, AFM, porosity, tensile strength, and zeta potential thoroughly characterized the membrane. Measurements of contact angle and water content uptake determined the membrane hydrophilicity. Evaluation of pure water flux (PWF), protein rejection, antifouling capability, and filtration performance of synthetic poultry wastewater propose the membrane separation performance. Data revealed that modified nanoparticles improved the ability of the membrane to resist fouling, and BSA rejection was above 95%. Accordingly, the PSf membrane with a 1:1 ratio of L-cysteine to CuO NPs showed the best UF performance.
Efficacy and Safety of Tuo-Min-Ding-Chuan Decoction on Mild Allergic Asthma: Study Protocol for a Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Single-Center Trial
Authors: Shao Dongmei , Lyu Mingsheng , Sun Pengcheng , Cui Hongsheng , Wang Ji , Wang Qi 
Published: September 2022

Abstract
Background: Allergic asthma (AA) is a common asthma phenotype. The variable and recurrent clinical symptoms cause a lot of pain to the patients, but there is no complete cure for the disease. It is worth noting that traditional Chinese medicine (TCM) has some advantages in the treatment of AA. Tuo-Min-Ding-Chuan Decoction (TMDCD) is an effective prescription from Professor Wang Qi, academician of the Chinese Academy of Engineering and master of Chinese medicine. Our previous studies with animal experiment have proved the efficacy of decoct TMDCD. Therefore, we designed a clinical trial to evaluate the safety and efficacy of TMDCD in the treatment of mild AA. Methods: This study is a single-center, randomized, double-blinded, placebo-controlled, parallel-group trial. 324 subjects will be recruited and randomized in a 1:1 ratio in the Intervention and control groups. The Intervention group and control group will be administered TMDCD granules and placebo granules, respectively. The primary outcome measures are the total dose of budesonide-formoterol and Total Asthma Symptom Score(TASS). The secondary outcome measures include times of AA exacerbation, Asthma Control Test(ACT), The fraction of exhaled nitric oxide (FeNO), total IgE and allergen specific IgE, lung function testing, Blood routine, Constitution in Chinese medicine questionnaire (CCMQ), Asthma Quality of Life Questionnaire(AQLQ) and the total dose of cetirizine hydrochloride. The study period will last for 60 weeks, including 12 weeks for treatment time and 48 weeks for follow-up period.
Discussion: We hypothesized that TMDCD might effectively relieve the symptoms of AA, reduce the number of relapses and the dosage of inhaled corticosteroids(ICS),and improve the quality of life of patients. Our hypothesis may be confirmed by the relevant data obtained in this study.
Trial registration: This trial has been registered with the Chinese Clinical Trial Registry. Trial registration number: ChiCTR2200056239. Registered 2 February 2022. http://www.chictr.org.cn.
Cold-atom sources for the Matter-wave laser Interferometric Gravitation Antenna (MIGA)
Authors: Beaufils Quentin , Sidorenkov Leonid A. , Lebegue Pierre , Venon Bertrand , Holleville David , Volodimer Laurent , Lours Michel , Junca Joseph , Zou Xinhao , Bertoldi Andrea , Prevedelli Marco , Sabulsky Dylan O. , Bouyer Philippe , Landragin Arnaud , Canuel Benjamin , Geiger Remi 
Published: September 2022

Abstract
The Matter-wave laser Interferometric Gravitation Antenna (MIGA) is an underground instrument using cold-atom interferometry to perform precision measurements of gravity gradients and strains. Following its installation at the low noise underground laboratory LSBB in the South-East of France, it will serve as a prototype for gravitational wave detectors with a horizontal baseline of 150 meters. Three spatially separated cold-atom interferometers will be driven by two common counter-propagating lasers to perform a measurement of the gravity gradient along this baseline. This article presents the cold-atom sources of MIGA, focusing on the design choices, the realization of the systems, the performances and the integration within the MIGA instrument.
Hemocompatibility and hemodynamic comparison of two centrifugal LVADs: HVAD and HeartMate3
Authors: Megías Antonio Gil , García Roberto Navarro , Igeño Pedro Quintero , Bou Andrea Mares 
Published: September 2022

Abstract
Mechanical Circulatory Support using Ventricular Assist Devices is a common technique for treating patients suffering from advanced heart failure. The latest generation of devices is characterized by centrifugal turbopumps which employ magnetic levitation bearings to ensure a gap clearance between moving and static parts. Despite the increasing use of these devices as a destination therapy, several long-term complications still exist regarding their hemocompatibility. The blood damage associated with different pump designs has been investigated profoundly in the literature, while the hemodynamic performance has been hardly considered. This work presents a novel comparison between the two main devices of the latest generation – HVAD and HM3 – from both perspectives, hemodynamic performance and blood damage. Computational Fluid Dynamics simulations are performed to model the considered LVADs, and computational results are compared to experimental measurements of pressure head to validate the model. Enhanced performance and hemocompatibility is detected for HM3 owing to its design incorporating more conventional blades and larger gap clearances.