bluuebunny/crossref_metadata_2025_split huggingface dataset:
KEBIJAKAN PERIZINAN INVESTASI MINUMAN KERAS DENGAN PENINGKATAN KRIMINALITAS
Authors: Khairiah Khairiah 
Published: March 2022

Abstrak: Kebijakan dalam bentuk perizinan investasi minuman keras telah memicu terjadinya peningkatan kekerasan dan kriminalitas di kalangan masyarakat. Penelitian ini bertujuan untuk mendeskripsikan tingkat kriminalitas yang disebabkan oleh kebijakan perizinan investasi minuman keras. Menggunakan metode kualitatif deskriptif. Hasil penelitian memperlihatkan; (1) Kebijakan perizinan investasi minuman keras beralkohol tidak ada manfaatnya, bahkan memiliki dampak negative di kalangan masyarakat; (2) Pengguna minuman keras beralkohol terjadi peningkatkan kriminalitas di kalangan masyarakat; (3) Kebijakan yang ada seyogyanya sebagai solusi dalam memberantas minuman keras beralkohol dan kriminalitas. Ini berbanding terbalik dengan peran fungsi kebijakan yaitu pengesahan perizinan investasi minuman keras. Sehingga tulisan ini dapat disimpulkan kebijakan perizinan investasi minuman keras memperlihatkan dampak negative dalam kehidupan masyarakat, dan pada akhirnya melalui berbagai pendapat para ahli dan organisasi masyarakat, maka Peraturan Presiden RI tersebut resmi dicabut. Sehingga tulisan ini menyarankan perlu dilakukan penelitian lanjutan dengan memperlihatkan aspek komparasi secara kewilayahan yang bersumber pada data yang lebih bervariasi. Dengan demikian kebijakan yang lebih akurat dapat dirumuskan dalam rangka meningkatkan investasi dan pendapatan Negara dengan tidak menimbulkan keresahan dan kriminalitas dalam masyarakat.Kata Kunci: Peningkatan Kriminalitas, Kebijakan, Investasi Minuman Keras Abstract: Policies in the form of licensing investment in liquor have triggered an increase in violence and crime in the community. This study aims to describe the crime rate caused by the liquor investment licensing policy. Using descriptive qualitative method. The research results show; (1) The investment licensing policy for alcoholic beverages has no benefits, and even has a negative impact on the community; (2) Users of alcoholic beverages have an increase in crime in the community; (3) The existing policy should be a solution in eradicating alcoholic beverages and crime. This is inversely proportional to the role of the policy function, namely the ratification of liquor investment licensing. So that this paper can conclude that the liquor investment licensing policy shows a negative impact on people's lives, and in the end through various opinions of experts and community organizations, the Presidential Regulation of the Republic of Indonesia is officially revoked. So this paper suggests that further research is needed by showing aspects of regional comparison that are sourced from more varied data. Thus, more accurate policies can be formulated in order to increase investment and state revenues without causing unrest and crime in society.Keywords: Increasing Crime, Policy, Investment in Liquor
Nonexercise Measurements as Predictors of Chronotropic Response to Exercise
Authors: Taylor J. David , Mathis Ruth Ann , Fletcher James P. , Walter Christopher S. , Meadors Olivia 
Published: March 2022

ABSTRACT

Background:
Chronotropic response to exercise is a clinically important health indicator. Direct assessment of chronotropic response to exercise is problematic in many clinical settings because of lack of access to required exercise equipment. Also, abnormal chronotropic response to exercise is often asymptomatic, which hinders the ability to identify individuals who require exercise-based chronotropic response evaluation. The purpose of this study was to investigate a set of nonexercise, contemporary assessments as predictors of chronotropic response to exercise.

Methods:
This prospective, cross-sectional study investigated nonexercise predictors of chronotropic response to exercise. Forty participants (19 women, 21 men; mean age = 34.3 years, SD = 14.5) performed a graded exercise work rate protocol while heart rate was continuously monitored. Chronotropic response to exercise was recorded as the heart rate-work rate slope. Data on a variety of nonexercise measures were also collected.

Results:
Multivariable regression analysis indicated that sex, self-reported physical activity, body mass index, waist circumference, and isometric grip strength were independent predictors of chronotropic response to exercise and, as a subset, resulted in the strongest prediction model (R = 0.80, R2 = 0.64, P &lt; 0.001).

Conclusion:
The results of this study suggest that a group of nonexercise measurements are predictive of chronotropic response to exercise. These findings provide a basis for future research to determine if these nonexercise predictors can be used to screen for chronotropic response to exercise abnormalities. Also, exercise interventions that target physical activity, body composition, and muscle strength may improve chronotropic response to exercise.
A Primer on Systematic Reviews and Meta-Analyses: Part II
Authors: Fisher Stuart , Pearson Melissa J. , Smart Neil A. 
Published: March 2022

ABSTRACT
In Part I of this primer (Volume 10, Issue 4) we reviewed the basic aspects of pooling data, generating forest plots, interpreting the data, and assessment of heterogeneity. In Part II we examine how to identify publication bias, conduct subanalyses and meta-regression, and introduce the advanced concept of individual patient data meta-analysis.
Antiplatelts Activity of Vitamin E in Relation to Dose and Duration of Therapy
Authors: O. Ibrahim Zaid , H. Ali Shatha 
Published: March 2022

Vitamin E, having the well known antioxidant activity through scavenging free radicals Ùˆ it occurs in several isomeric forms , these isomers have relatively different functions . One of these actions is related to its ability to inhibit platelets aggregation and hence thrombosis. The present study included a total number of apparently healthy 62 males . 11of them served as standard group , treated with 100 mg aspirin /day for more than one month . Another 31 subjects were randomly grouped into 5 groups that received different daily doses of Î± â€“ tocopherol : 400 IU , 800 IU and 1200 IU for 2-6 months.The remainder ( 20 ) subjects served as a control group ( received no therapy ) . Platelets function was assessed based on measuring bleeding time and Slide Platelets Aggregation Time ( SPAT ) Meanwhile , thiobarbituric acid reactive substances (TBARS) were measured as a marker for oxidative stress. The results showed that the commercially available vitamin E preparations (Î±- tocopherol ) could exert anti-coagulant effect ,such effect is more dependant on duration of therapy , rather than dose related action .In addition to itâ€™s antioxidant effect, which seems to be significantly correlated to itâ€™s antiplatelets effect ( r=0.994 ,p<0.05).Hence , long term administration of high doses of vitamin E could be effective in decreasing the incidence of thrombosis ,which in turn depends on platelets function. Such effect might not affect bleeding time obviously , but it could reduce chances for platelets recruitment , which might represent an additional advantageous action for vitamin E over other antioxidants.
Key Words : Vitamin E , Î± - Tocopherol , Antiplatelets
Therapeutic Effects of Melatonin in Lead-Induced Toxicity in Rats
Authors: G. Alabbassi Mustafa , A. Hussain Saad , H. Ali Shatha 
Published: March 2022

Exposure to lead results in significant accumulation in most of vital organs, and free radical damage has been proposed as a cause of lead-induced tissue damage, where oxidative stress is a likely molecular mechanism. This study was designed to evaluate therapeutic effects of melatonin in lead-induced organ toxicity in rats. The therapeutic effects of melatonin on lead induced toxicity in rats were evaluated using 36 rats, which were allocated into 3 groups and treated as follows: Group I, includes 12 rats injected subcutaneously with 0.2 ml physiological saline for 30 days, followed by treatment with a daily dose of 20mg/kg melatonin, administrated I.P for the successive 30 days; groups II and III, each includes 12 rats , injected with lead acetate 100 mg/kg/day s.c for 30 days, followed by treatment with intraperotoneal injection of physiological saline (0.2 ml) or melatonin 20mg/kg/day for the next 30 days. At the end of treatment period, the rats were sacrificed by an overdose (100mg/kg) of thiopental (twenty-four hour after the last injection). Craniotomy and laparotomy were performed to obtain the brains, livers and kidneys for the assessment of tissue damage. The changes in total body weight, weight of major organs (brain, liver and kidney), oxidative stress parameters, hemoglobin content, liver and renal functions, and histological appearance of the studied organs were evaluated and compared with that of negative and positive controls. Treatment with melatonin reverses the damage induced by lead in many organs and tissues through the reduction of MDA levels in RBCs, brain, liver and kidney; increases GSH levels in all studied organs; in addition to the improvement in the indices of the functions of the organs studied. These findings demonstrated that melatonin is capable of reversing damage of rat tissues caused by successive doses of lead acetate, and animals had restored their organ functions due to treatment with melatonin.
Key words: Melatonin, Lead poisoning, Oxidative stress
Rosiglitazone , Metformin or both for Treatment of Polycystic Ovary Syndrome
Authors: A.Taher Mohammed , R. Sulaiman Waleed , Y. Al-Khairi Hillal 
Published: March 2022

This study was designed to show the advantages of using the combination of metformin and rosiglitazone over using each drug alone in treatment of women with polycystic ovary syndrome (PCOS).Forty four women with PCOS were classified into 3 groups , group 1 received rosiglitazone (4mg/day) for 3 months , group Î™Î™ received metformin ( 1500 mg/day)for three months and groupÎ™Î™Î™ received the combination ( rosiglitazone 4mg/day + metformin 1500 mg/day) for the same period of treatment . The blood samples were drawn before treatment and after 3 months of treatment . The fasting serum glucose , insulin , progesterone , testosterone , leutinizing hormone were measured before and after treatment. The reduction of serum insulin , glucose ,homostasis model assessment of insuline resistance ( HOMA-IR) , LH and testosterone levels were greater in the group received the combination of rosiglitazone with metformin than that those taken each one alone. Testosterone levels decreased significantly (P<0.05) from baseline level 1Â±0.04ng/ml to 0.073Â±0.32ng/ml after treatment with combination.The rate of ovulation is 29.4%,36.4% , 62.5% in rosiglitazone , metformin and combination of both, respectively.The combination of rosiglitazone with metformin has more beneficial effect on ovulation rate.
Key words: polycystic ovary syndrome, rosiglitazone, metformin, ovulation rate .
Investigation of the effect of TNF-α on damage to retinal pigment epithelial cells in age-related macular degeneration
Authors: Malachkova N. V. , Mohammad Mashhour Mohammad Masa’deh 
Published: March 2022

Oxidative stress alters cellular homeostasis and elicits a cellular response that depends on the severity and type of damage: some cells activate defense mechanisms designed to ensure survival; the other, provided that the defense mechanisms are inhibited, triggers alternative signaling pathways that lead to apoptosis, necrosis, pyroptosis, autophagy, and so on. However, the exact cause of such damage and induction of oxidative stress, including the associated oxidative effects around pigment epithelial cells in the context of the onset and progression of age-related macular degeneration – one of the world’s most common eye diseases with blindness, remains unclear. Therefore, in the course of the study we turned to key biogenetic points of regulation of inflammation and apoptosis, in particular TNF. The aim of the work is to shed light on the role of TNF as a genetic determinant that can initiate and influence the course of age-related macular degeneration. For this purpose, the main pathognomonic markers of the morphological structure of the macula were determined in 291 persons with age-related macular degeneration and in 105 persons without ophthalmic pathology, using optical coherence tomography to confirm or exclude the diagnosis of the disease. To detect polymorphism of the TNF gene, we used the method of real-time PCR diagnostics on the BioRad CFX 96 amplifier using LiTech reagents. Statistical processing of the results was performed using Hardy-Weinberg equilibrium, Kruskal-Wallis method, logistic regression analysis and construction of the ROC curve to determine the AUC range and sensitivity and specificity values. The study revealed a significant difference in the distribution of mutant genotypes between patients with both forms of AMD and the control group. There was also a statistically significant effect of mutant allele A on the development of both "dry" (OR = 3.40; 95.0 %; CI = 1.90-6.07, p<0.001) and "wet" form of AMD (OR = 4.78; 95.0 % CI 2.65-8.64, p<0.001), and in the analysis of mutant genotypes it was found that the GA genotype increases the chances of "dry" and "wet" forms of the disease by 3.13 and 4.74 times, respectively, while AA – 5 times, regardless of the form of the disease. confirms the influence of TNF gene polymorphism on the occurrence and progression of age-related macular degeneration. In the analysis of ROC-curves and AUC regions, it was found that all mutant genotypes have a significant effect on the occurrence of age-related macular degeneration (p<0.05). However, the obtained values of sensitivity and specificity, especially in the AA genotype in both "dry" (17.9 % and 95.8 %, respectively) and "wet" (18.2 % and 95.8 %, respectively) forms of age-related macular degeneration indicate a low chance of error-free confirmation of the diagnosis. a disease that may be associated with multifactorial disease and requires further research.
The results of morphological studies in women of reproductive age with hyperproliferative diseases of the endometrium
Authors: Abdullaiev V. E. 
Published: March 2022

Hyperproliferative processes of the endometrium, remaining one of the most common gynecological pathologies, still have imperfections in the diagnostic stages, both invasive and non-invasive. There is still controversy about the need to differentiate between hyperplasia and endometrial polyps. And the improvement of the method of pathomorphological research and the invention of immunohistochemical markers for the endometrium, opened new opportunities for better diagnosis of hyperproliferative processes of the endometrium. Also, an important component of the diagnosis of endometrial pathology are invasive methods, namely hysteroscopy, which has eliminated most of the shortcomings associated with the classic scraping of the uterine cavity. The definition of markers of chronic endometritis has opened new questions about the origin of chronic inflammation in the uterine cavity, its course and the relationship with the biocenosis of the lower genital tract. The aim of this study was to determine the role of pathomorphological immunohistochemical cytological methods of examination and microscopy in patients of reproductive age with hyperproliferative processes of the endometrium. In order to achieve this goal, we analyzed 161 women, of whom 58 women had verified diagnoses of endometrial hyperproliferative processes, 71 women were morphologically verified diagnoses of hyperproliferative processes in combination with chronic endometritis. The control group consisted of 32 women without evidence of hyperproliferative processes of the endometrium and chronic endometritis. The age of women ranged from 18 to 53 years. Also, all women underwent cytological examination of the cervix and microscopy of vaginal swabs. According to the data obtained, the percentage ratio between the number of diagnosed endometrial polyps and endometrial hyperplasia was equal, with a slight advantage towards endometrial polyps. Other gynecological diseases such as uterine fibroids, external endometriosis and cervical polyps accounted for a total of 0.8 to 3.9 %. Cytological examination of the cervix indicated the predominance of type 2 cytology in the group of women with chronic endometritis. Analysis of microscopic data of vaginal secretions indicates an increased level of inflammation in the group of women with a combination of hyperplastic processes of the endometrium and chronic endometritis. In conclusion, it is possible to claim a slightly higher level of chronic endometritis in the group of women with endometrial polyps, compared with endometrial hyperplasia. There is also a clear link between the diagnosis of chronic endometritis and inflammatory changes in cytological examination of the cervix and microscopy of vaginal discharge. Comparison of the results of the above diagnostic methods can improve the diagnosis of hyperproliferative processes of the endometrium and chronic endometritis, with the further development of effective treatment methods.
Sistem Otomatisasi Pengisian Air Di Area Waterfill Berbasis Mikrokontroler
Authors: Putra Erlan Sukowati 
Published: March 2022

Dalam perkembangan teknologi yang begitu pesat, suatu sistem dan logika yang diimplementasikan pada mikrokontroler dapat menghasilkan otomatisasi pergerakan sehingga dapat membantu dalam bekerja maupun memecahkan suatu permasalahan yang timbul dalam suatu instansi maupun industri. Dalam hal ini penulis membuat “Sistem Otomatisasi Pengisian Air Di Area Waterfill Berbasis Mikrokontroler” dengan misi mengubah sistem pengisian yang berada di PT. Saptaindra Sejati Jobsite Boro yang awalnya masih berbasis manual menjadi otomatis, sehingga engine akan otomatis bekerja tanpa memerlukan operator. Dengan Arduino Nano sebagai pusat kendalinya, sensor E18-D80NK yang terpasang di tiga titik pada area waterfill yaitu 2 sensor di jalur antrian dan satu sensor di jalur pengisian yang berfungsi untuk mendeteksi ada tidaknya Unit WT (Water Truck) di area waterfill tersebut. Sensor hujan sebagai pendeteksi cuaca sekaligus memposisikan OFF pada engine waterfill pada saat hujan. Modul relay 2 chanel sebagai output action untuk memposisikan ON atau OFF pada engine waterfill, dan led sebagai indikatornya. Hasil analisa penelitian selama 4 hari, alat tersebut dapat mengontrol aktivitas engine waterfill dan juga mengefisiensi waktu running sebesar 8 jam dari 12.44 jam waktu normal saat engine waterfill masih menggunakan sistem manual, serta menghemat penggunaan fuel sebanyak 54.77 liter atau setara 64.31% dan hanya mengonsumsi fuel sekitar 35.69% dari konsumsi 85.16 liter pada sebelumnya yang masih menggunakan sistem manual. Kata Kunci: Arduino Nano, Sensor E18-D80NK, Sensor Hujan, Waterfill.
Sosialisasi Pelestarian Lingkungan Dan Kegunaan Pohon Enau (Arenga Pinnata) Sebagai Upaya Mewujudkan Ekowisata Desa Dayeuhkolot Kabupaten Subang Jawa Barat
Authors: Wachidah Lisnur , Yanti Teti Sofia , Krishnamurti Yani , Kurniati Eti , Kurniaty Nety , Firdaus Alfiari , Nugraha Andi Setia 
Published: March 2022

Tujuan kegiatan Pengabdian Kepada Masyarakat yang kami lakukan ialah untuk meningkatkan wawasan masyarakat Desa Dayeuhkolot kabupaten Subang Jawa Barat menjadi desa Ekowisata, sehingga ada peningkatan pendapatan daerah serta meningkatkan kesejahteraan masyarakat. Di desa Dayeuhkolot, musibah banjir dan tanah longsor adalah kejadian yang terjadi pada musim hujan. Untuk mengatasi masalah tersebut, maka langkah awal dari kegiatan pengabdian yang kami lakukan adalah melakukan kegiatan tentang pelestarian lingkungan dan kegunaan pohon Enau (Arenga Pinnata). Metode yang kami lakukan adalah dengan sosialisasi, penyuluhan/edukasi tentang lingkungan dan keguanaan dari pohon enau. Untuk mengetahui efektifitas peningkatan pengetahuan sosialisasi dan penyuluhan kami melakukan pretest dan postest, hasil dari pengujian dengan menggunakan statistik uji t dan taraf nyata (α) 5% dapat disimpulkan bahwa sosialisasi dan penyuluhan efektif meningkatkan pengetahuan masyarakat desa Dayeuhkolot.
Solubility Enhancement of Poorly Water Soluble Drug by Using β Cyclodextrin
Authors: S Sathvik , S Nagaraja T. , R Yogananda , Snehalatha  , N Chethan Patel D. 
Published: March 2022

Aceclofenac complex is prepared by kneading method of inclusion complexation. The aim of present work is to improve the solubility and dissolution properties of a poorly water soluble drug aceclofenac, by inclusion complexation technique. Two components namely β cyclodextrin and span 60 were used in this study, β CD is used as complexing agent and span 60 as surfactant which helps in increasing solubility and dissolution. The prepared Aceclofenac complex is evaluated in terms of compatibility, solubility, dissolution behavior with the help of FTIR, DSC, In vitro dissolution studies. The complexation parameter of β CD had an impact on the solubility of drug. The solubility of complexes was progressively improved when compared to pure Aceclofenac drug in water. The prepared Aceclofenac complexes were subjected to dissolution study. At the end of 60 min of dissolution study 22.32±0.42 of pure drug was dissolved. The prepared complexes showed 85.35±0.71 at 60 min. The percent of drug dissolved increased for the complexes prepared with high concentration of β CD. The study showed that complexing property of β CD and surfactant action of span 60 has its influence on both solubility and dissolution of the prepared inclusion complexes. MDT and % DE was evaluated for the all the prepared complexes. Aceclofenac complexes prepared with high concentration of β CD showed lower MDT and higher % DE compared to pure Aceclofenac. The pure and complexed Aceclofenac were characterized by DSC studies. DSC studies showed that there was no appreciable change in the melting endotherm of prepared complexes compared to that of pure drug. The drug release from the above follows Korsemeyer-Peppas model and release mechanism was Non- Fickinian.
Keywords: Aceclofenac, inclusion complex, kneading method, complexing agent, solubility, dissolution.
KUALITAS SISTEM INFORMASI UNTUK MENINGKATKAN EFEKTIVITAS LAYANAN PENGADUAN MASYARAKAT BERBASIS ONLINE DI DINAS KOMUNIKASI DAN INFORMATIKA KOTA BANDUNG PROVINSI JAWA BARAT
Authors: Nangameka Teresa Irmina 
Published: March 2022

This research focuses on describing and analyzing the effectiveness of the Online-Based Public Complaints Information System which been known LAPOR! from information system quality’s perspective in Bandung city. LAPOR! is a concrete step to integrate the management of public service complaints so that it requires all Ministries / Institutions and Local Governments to be involved in its management. The phenomenon of problems that occur in Bandung related to the application of LAPOR! are complaints channels of each agency that have not been integrated in LAPOR!, LAPOR!'s socialization which is still uneven, also there are reports of complaints that have not been resolved, and public perceptions about complaints online itself.
The researcher used the information systems theory of DeLone and McLean (2013). Combining a qualitative theory with a descriptive approach and also using interview, observations and documents about LAPOR! conducted by the Agency of Communication and Information of Bandung city, these are how the researcher works.
The results showed that the quality of information system of LAPOR! can increase the effectiveness of managing public service complaint. LAPOR! with its features and menu has been able to facilitate several community problems through the system. Some problems of information system that occur such as network, maintenance, and features availability, or technical errors still can be handled by internal experts in the agency. In terms of website interface of LAPOR!, the addition of graph report of complaint in website can improve its management.
Keywords: LAPOR!, effectiveness, information systems