bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumbling and subsequent aging improves tenderness of beef longissimus lumborum and semitendinosus steaks by disrupting myofibrillar structure and enhancing proteolysis
Authors: Tuell Jacob R , Nondorf Mariah J , Abdelhaseib Maha , Setyabrata Derico , Kim Yuan H Brad 
Published: March 2022

Abstract
Tenderness is an important sensory attribute to the overall eating experience of beef. Identifying novel methods to ensure consistent tenderness, especially in inherently tough cuts, is critical for the industry. This study investigated if tumbling without brine inclusion could be an effective method to improve the quality and palatability attributes of beef longissimus lumborum (LL) and semitendinosus (ST) steaks. Furthermore, interactions with postmortem aging were evaluated to determine how tumbling might affect protein degradation and muscle ultrastructure. At 5 d postmortem, pairs of LL and ST muscles from beef carcasses (n = 16) were bisected, vacuum packaged, and tumbled for 0, 40, 80, or 120 min. Sections were divided and subsequently aged an additional 0 or 10 d at 2 °C. Tumbling for any duration improved instrumental tenderness of LL (P &lt; 0.001) but not ST (P &gt; 0.05) steaks, regardless of aging time. Tumbling exacerbated moisture loss in both muscles shown by greater purge and cooking losses (P &lt; 0.05). Myofibrillar fragmentation was induced through tumbling in both muscles (P &lt; 0.001), which was supported by transmission electron microscopy images. Tumbling for 120 min followed by 10 d of aging resulted in less abundant intact troponin-T in both LL and ST (P &lt; 0.05), as well as less intact desmin in ST (P &lt; 0.05); however, calpain-1 autolysis was not affected by tumbling (P &gt; 0.05). No effects of tumbling, aging, nor the interaction were found for the content and solubility of collagen (P &gt; 0.05). Consumer panelists (n = 120/muscle) rated LL steaks tumbled for any duration higher for tenderness and overall liking compared to control steaks (P &lt; 0.05). For ST, significant interactions were found for consumer liking of tenderness and juiciness. In general, tumbling without subsequent aging resulted in poorer juiciness than non-tumbled (P &lt; 0.05), while at 10 d no differences in juiciness were found between treatments (P &gt; 0.05). For ST steaks that were aged 10 d, 120 min of tumbling resulted in greater tenderness liking than non–tumbled steaks (P &lt; 0.05). These results suggest that tumbling would result in myofibrillar fragmentation and may benefit the degradation of myofibrillar proteins; however, there would be negligible impacts on collagen. Accordingly, tumbling without brine inclusion alone may be sufficient to improve tenderness and overall liking of LL steaks, while combined tumbling with subsequent postmortem aging would be necessary to improve tenderness liking of ST.
Assessing Insecticide Susceptibility and Resistance Intensity of Anopheles gambiae s.l. Populations From Some Districts of Benin Republic, West Africa
Authors: Kpanou Casimir Dossou , Sagbohan Hermann W , Sovi Arthur , Osse Razaki , Padonou Gil G , Salako Albert , Tokponnon Filémon , Fassinou Arsène Jacques , Yovogan Boulais , Nwangwu Udoka C , Adoha Constantin J , Odjo Esdras Mahoutin , Ahogni Idelphonse , Sidick Aboubakar , Saïd Baba-Moussa Lamine , Akogbéto Martin 
Published: March 2022

Abstract
Pyrethroid resistance is widespread in sub-Saharan Africa. The objective of this study was to assess the insecticide resistance intensity in Anopheles gambiae s.l. (Diptera: Culicidae) in four districts of Benin in order to better understand how pyrethroid-only nets are likely to be effective. Thus, adult females of An. gambiae s.l., reared from field-collected larvae were used for assessing resistance intensity to permethrin and deltamethrin. They were tested at 1×, 5×, and 10× the diagnostic dose, using both WHO susceptibility tube testing and CDC bottle bioassays. Identification of molecular species, as well as of L1014F Kdr and Ace-1R mutations was performed using the PCR. The level of expression of biochemical enzymes was also evaluated. Overall, moderate to high resistance intensity to permethrin and deltamethrin was observed, irrespective of the testing method. While the L1014F Kdr frequency was high (&gt;75%), Ace-1R was low (≤6%) in An. gambiaes.s. and Anopheles coluzzii, the two predominant species [52% (95% CI: 44.8–59.1) and 45% (95% CI: 38.0–52.2), respectively]. Anopheles arabiensis was found at very low frequency (3%, 95%CI: 1.1–6.4). For Biochemical analyses, α and β-esterases were over-expressed in all four districts, while mixed-function oxidases (MFOs) were over-expressed in only one. Overall, the two testing methods led to comparable conclusions, though there were a few inconsistencies between them. The moderate-high resistance intensity observed in the study area suggests that dual active-ingredient (AI) long-lasting insecticidal nets (LLINs) may provide better control of insecticide-resistant mosquitoes.
Race, Specificity, and Statistics in Victorian Medicine
Authors: Seth Suman 
Published: March 2022

Abstract
This paper focuses on Edmund Parkes’ Manual of Practical Hygiene, Prepared Especially for Use in the Medical Service of the Army (1864), a text that would become the standard within British military medicine for decades to come. Within Parkes’ Manual, I argue, we can see the confluence of three streams of thinking – each beginning in the 1830s and 1840s – that led to a new orthodoxy on race-medicine in the Victorian period. The first flowed from an ‘avalanche of numbers’, to use Hacking’s phrase, concerning military medical statistics, a set of seemingly objective data that made race medically ‘real’ in a form that had not been evident before. The second was the solidification of fixist conceptions of race after the collapse of what George Stocking called the ‘Prichardian paradigm’ in British ethnology. The third involved what has become known, in the history of medicine, as the ‘doctrine of specific etiology’, the idea that the cause of certain diseases was the cause of each of those diseases alone. These three factors together led to a novel set of racial arguments, one that assumed the reality and permanence of race and that explained differences in susceptibility and immunity not, as was common earlier, in terms of climatic habituation, but rather in terms of the fixity and peculiarity of internal differences.
Pain catastrophizing
Authors: Thompson Osheeca J. , Powell-Roach Keesha , Taylor Janiece L. , Terry Ellen L. , Booker Staja Q. 
Published: March 2022

Abstract:
Pain is a subjective experience and its perception and expression vary widely. Pain catastrophizing, which refers to patients' thoughts or feelings about their pain, may impact their communication of pain and nurses' subsequent response. This article discusses how nurses can more readily recognize, assess, and manage pain catastrophizing.
Nurses' critical role in CPT code valuation
Authors: Volpert Elisabeth , Van Keuren Korinne , Trainum Brooke 
Published: March 2022

Abstract:
Relative value units (RVUs) are a measurement of practice efficiency and patient complexity. RVUs are reviewed by the Centers for Medicare and Medicaid Services through the Resource-Based Relative-Value Scale Update Committee, which determines recommendations regarding the Current Procedural Terminology code valuations for the Medicare Physician Fee Schedule. This article discusses the importance of nurses' participation in the accurate valuation of their work and in the process of developing and revising RVUs.
Abortion Safety and Use With Normally Prescribed Mifepristone in Canada
Authors: Schummers Laura , Darling Elizabeth K. , Dunn Sheila , McGrail Kimberlyn , Gayowsky Anastasia , Law Michael R. , Laba Tracey-Lea , Kaczorowski Janusz , Norman Wendy V. 
Published: March 2022

(Abstracted from N Engl J Med 2022;386:57–67)
A medical abortion regimen of mifepristone and misoprostol is safe. In the United States, mifepristone is approved for use only with onerous Risk Evaluation and Mitigation Strategy (REMS) restrictions, which include mandatory prescriber certification, observed dispensing of doses by the prescriber or medical facility (excluding pharmacies), and with submission of a prespecified patient consent form.
Screening for Autosomal Recessive and X-Linked Conditions During Pregnancy and Preconception: A Practice Resource of the American College of Medical Genetics and Genomics (ACMG)
Authors: Gregg Anthony R. , Aarabi Mahmoud , Klugman Susan , Leach Natalia T. , Bashford Michael T. , Goldwaser Tamar , Chen Emily , Sparks Teresa N. , Reddi Honey V. , Rajkovic Aleksandar , Dungan Jeffrey S. 
Published: March 2022

(Abstracted from Genet Med 2021;23:1793–1806)
Carrier screening can be used to determine if an individual or couple is at risk to have a child with an autosomal recessive or X-linked genetic disorder. The American College of Medical Genetics and Genomics (ACMG) last published documents specific to carrier screening in 2004 and 2008.
The Supreme Court, the Texas Abortion Law (SB8), and the Beginning of the End of Roe v Wade?
Authors: Cohen I. Glenn , Adashi Eli Y. , Gostin Lawrence O. 
Published: March 2022

(Abstracted from JAMA 2021;326:1473–1474)
A total of 13 states have enacted fetal heartbeat laws banning abortion once embryonic cardiac activity is detected. Despite enforcement of these laws being found unconstitutional by various courts, on September 1, 2021, the US Supreme Court allowed passage of a Texas fetal heartbeat law (SB8).
Use of a Smartphone App to Explore Potential Underuse of Prophylactic Aspirin for Preeclampsia
Authors: Krishnamurti Tamar , Davis Alexander L. , Rodriguez Samantha , Hayani Laila , Bernard Miriam , Simhan Hyagriv N. 
Published: March 2022

(Abstracted from JAMA Netw Open 2021;4:e2130804)
Preeclampsia is a leading factor associated with maternal and neonatal morbidity and mortality. Effective prophylaxis can be achieved with low-dose aspirin (LDASA) 75 to 150 mg daily during pregnancy if initiated early in moderate- to high-risk patients.
Description of Clinician-Diagnosed Regression at Time of Autism Spectrum Disorder Diagnosis in Toddlers
Authors: Zaro Christopher , Harris Holly , Sideridis Georgios , Barbaresi William , Harstad Elizabeth 
Published: March 2022

ABSTRACT:

Objective:
Previous studies have reported varying rates of regression in children with autism spectrum disorder (ASD). We sought to (1) determine the rate of clinician-diagnosed regression for young children with ASD and (2) compare developmental functioning and ASD symptoms of children with versus without regression.

Methods:
We conducted a retrospective chart review of toddlers (age 18–36 months) with Diagnostic and Statistical Manual-5 ASD. We abstracted cognitive, language, adaptive, and motor functioning standard scores and ASD core symptoms. Regression was defined as “clinician-diagnosed regression accompanied by recommendation for a medical workup.” We used propensity scores to match each participant with regression (n = 20) one-to-one with a participant without regression (n = 20). We compared the groups on developmental scores using independent sample t tests and on core ASD symptoms using Pearson's χ2 test.

Results:
Of the 500 children with ASD, n = 20 (4%) had regression (defined above). Children with regression had lower Bayley cognitive and language scores and lower Vineland adaptive scores compared with those without regression (cognitive: 78.0 vs 85.5, p < 0.05; language: 56.9 vs 68.2, p < 0.01; adaptive: 70.0 vs 80.3; p < 0.01). There was no difference in motor scores across groups. There were no significant differences in the frequency of exhibiting core ASD symptoms for those with versus without regression.

Conclusion:
In this clinical sample of children with ASD, regression was diagnosed in a small percentage (4%). Those with regression had lower cognitive, language, and adaptive skills compared with those without regression. Rates of clinician-diagnosed regression referred for medical workup are significantly lower than prior estimates based on parent report.
Postoperative anxiety and depression in surgical gastric cancer patients: their longitudinal change, risk factors, and correlation with survival
Authors: Liu Ping , Wang Zhe 
Published: March 2022

Abstract
Anxiety and depression are important concerns negatively affecting life quality and prognosis in cancer patients. Then, this prospective cohort study aimed to explore the longitudinal change and potential risk factors for postoperative anxiety and depression in surgical gastric cancer patients.
A total of 226 surgical gastric cancer patients were consecutively enrolled. The Hospital Anxiety and Depression Scale (HADS) was used to assess the anxiety and depression status at baseline (M0), 12th month (M12), 24th month (M24), and 36th month (M36) after hospital discharge, then the HADS for anxiety (HADS-A) score and HADS for depression (HADS-D) score were calculated. Diseasefree survival (DFS) and overall survival (OS) were evaluated.
HADS-A and HADS-D scores were gradually increased from M0 to M36, and their occurrences and grades were also worsened piece by piece. Additionally, older age, female, unemployed before surgery, single/divorced/widowed marry status, poor education duration, diabetes, hyperlipidemia, large tumor size, high TNM stage, and adjuvant chemotherapy were independent risk factors for postoperative anxiety or depression. Regarding survival, DFS and OS appeared to be shorter in anxiety patients compared to nonanxiety patients at M0 but showed no statistical significance. However, DFS and OS were worse in depression patients compared to non-depression patients at M0.
In conclusion, postoperative anxiety and depression are gradually worsened, relating to poor prognosis, and their main risk factors include female, single/divorced/widowed marry status, diabetes, hyperlipidemia, large tumor size, and high TNM stage in gastric cancer patients.
Oral pigmentation as an adverse effect of chloroquine and hydroxychloroquine use
Authors: Silva Pedro Urquiza Jayme , Oliveira Millena Barroso , Vieira Walbert , Cardoso Sérgio Vitorino , Blumenberg Cauane , Franco Ademir , Siqueira Walter Luiz , Paranhos Luiz Renato 
Published: March 2022

Abstract

Background
Chloroquine and hydroxychloroquine are 2 medications used to treat some systemic diseases.

Objective
The aim of this scoping review was to assess the occurrence of oral pigmentation induced by chloroquine or hydroxychloroquine and to understand the pathogenic mechanism behind this phenomenon.

Methods
The review was performed according to the list of PRISMA SrC recommendations and the JBI Manual for Evidence Synthesis for Scoping Reviews. MEDLINE (PubMed), Scopus, EMBASE, SciELO, Web of Science, Lilacs, and LIVIVO were primary sources, and “gray literature” was searched in OpenThesis and Open Access Thesis and Dissertations (OATD). Studies that screened the occurrence of oral pigmentation associated to the use of chloroquine or hydroxychloroquine were considered eligible. No restrictions of year and language of publication were applied. Study selection and data extraction were performed by 2 independent reviewers. The risk of bias was assessed through the JBI tool, depending on the design of the selected studies.

Results
The initial search resulted in 2238 studies, of which 19 were eligible. Sixteen studies were case reports, 2 had case-control design and 1 was cross-sectional. Throughout the studies, 44 cases of oral pigmentation were reported. The hard palate was the anatomic region most affected with pigmentation (66%). According to the case reports, most of the lesions (44%) were bluish-gray. The minimum time from the beginning of treatment (chloroquine or hydroxychloroquine) to the occurrence of pigmentation was 6 months. The mean treatment time with the medications was 4.9 years, and the mean drug dosage was 244 mg. Most of the studies (63.1%) had low risk of bias (high methodological quality).

Conclusions
The outcomes of this study suggest that hyperpigmentation depend on drug dosage and treatment length. Hyperpigmentation was detected after a long period of treatment with chloroquine or hydroxychloroquine.
Associations of walking and resistance training with chronic low back pain in older adults
Authors: Nah Sangun , Park Seong San , Choi Sungwoo , Jang Hae-Dong , Moon Ji Eun , Han Sangsoo 
Published: March 2022

Abstract
Physical activities, such as resistance training and walking, are known to be effective against chronic low back pain (CLBP). However, few studies have examined the associations of walking and resistance training with CLBP in the general older population. Therefore, this study analyzed these relationships in the older Korean population (aged ≥65 years), with the goal of determining which exercise is better for CLBP.
This cross-sectional study analyzed Korean National Health and Nutrition Examination Survey data for the period 2012 to 2015. The Korean National Health and Nutrition Examination Survey, which provides representative data for the Korean population, uses a clustered, multistage, random sampling method with stratification based on geographic area, age, and sex. Three multiple logistic regression models were generated in this study to determine the associations of walking and resistance training with CLBP.
A total of 5233 participants were enrolled, 3641 (69.6%) of whom were free from CLBP; the remaining 1592 (30.4%) had CLBP. 78.4% and 64.8% of the non-CLBP and CLBP group patients, respectively, walked at least once a week. Also, 23.5% and 11.6% of the participants in the non-CLBP and CLBP groups, respectively, engaged in resistance training at least once a week. In the multiple logistic regression analysis, which was adjusted for all potential confounders, walking was significantly associated with a lower risk of CLBP (1-2d/wk: odds ratio [OR] = 0.65, P = .002; 3-4d/wk: OR = 0.69, P = .004; ≥5 d/wk: OR = 0.57, P < .001). However, resistance training showed no association with the risk of CLBP.
In this cross-sectional study, walking was associated with a lower risk of CLBP. In particular, walking >5days per week had the maximum benefit in a lower risk of CLBP. Therefore, clinicians can consider recommending walking to patients with CLBP for optimal pain improvement.
Efficacy of Geumguesingi-hwan (jinkuishenqi-wan, kinkijinki-gan) in decreasing blood glucose levels in patients with uncomplicated type 2 diabetes
Authors: Choi Hyun-Jin , Baek Ji-Soo , Jeon Cheon-Hoo , Shin Seon-Mi , Cho Chung-Sik 
Published: March 2022

Abstract

Background:
The purpose of a systematic review and meta-analysis is to verify the clinical efficacy and safety of Geumguesingihwan for patients with uncomplicated type 2 diabetes.

Methods:
The systematic review and meta-analysis will be performed following the guidelines of the National Evidence-based Healthcare Collaborating Agency. We will conduct a systematic search of randomized controlled trials in 8 electronic databases until August 31, 2021.

Results:
This study will provide evidence regarding the clinical efficacy of Geumguesingi-hwan from the following 3 perspectives: improving blood glucose level, insulin resistance, and β-cell function. Additionally, we will examine the safety of Geumguesingi-hwan by evaluating the adverse effects.

Conclusions:
This study will verify the antidiabetic efficacy and safety of Geumguesingi-hwan in patients with uncomplicated type 2 diabetes.
Incidence and risk factors of preoperative isolated calf deep venous thrombosis following hip fractures
Authors: Zhao Weiguang , Zhao Jianlong , Liu Tiantian , Liu Zhenwu , Liu Li 
Published: March 2022

Abstract
There is still a lack of data on isolated calf deep vein thrombosis (ICDVT) following hip fractures surgery. The study aimed to determine the incidence of preoperative ICDVT and the associated risk factors in patients with hip fractures requiring surgery.
The 289 patients who required hip surgery were included, duplex ultrasonography was routinely used to make a definite diagnosis of preoperative ICDVT located in unilateral or bilateral calf. Data on demographics and laboratory-associated blood biomarkers results were included. Univariate analyses were used to analyse the data of demographics, comorbidities, personal history operation related indexes and laboratory biomarkers, then the multivariate logistic regression analysis was employed to identify the independent risk factors associated with ICDVT.
Sixty-eight (23.5%) patients were diagnosed with preoperative ICDVTs. The univariate analyses showed significant differences regarding ICDVT were age, current smoking, alcohol consumption, time from injury to operation, albumin, white blood cells, lymphocyte, red blood cells, hemoglobin, hematocrit, and activated partial thromboplastin time level among the 44 factors. The multivariable model confirmed 3 risk factors were significantly independent in association with preoperative ICDVTs, including current smoking, time delay from injury to operation and activated partial thromboplastin time ( < 28seconds).
The incidence of preoperative ICDVT in hip fracture was 23.5%, and patients with associated risk factors are prone to form ICDVTs, identification of these factors may help to reduce the incidence of ICDVT with hip fractures by taking early prevention measures.
The effectiveness and safety of Simiao Xiaobi decoction on rheumatoid arthritis
Authors: Chae Soo-Yeon , Woo Yeonju , Kim Joo-Hee , Kim Eun-Jung , Seo Byung-Kwan , Baek Yong-Hyeon , Park Seong-Sik , Sung Won-Suk 
Published: March 2022

Abstract

Background:
Rheumatoid arthritis (RA) is a common chronic autoimmune disease that contributes to progressive disability, systemic complications, higher mortality, and societal burden. Typical symptoms of RA include symmetrical pain and swelling in multiple joints, morning stiffness, and elevated levels of erythrocyte sedimentation rate, C-reactive protein, and rheumatoid factor. The representative treatment for RA is medication, including disease-modifying antirheumatic drugs, glucocorticoids, and nonsteroidal anti-inflammatory drugs. However, these medications are not yet curative nor preventative and are associated with several adverse effects, leading to their discontinuation. Recent articles reported that Simiao Xiaobi decoction (SXD) could relieve the symptoms of RA by clinical trial and experimental study, but an evidence-based review on the effectiveness and safety of SXD on RA has not yet been provided.

Methods:
Searching for randomized controlled trials on the use of SXD for RA will be performed by using multiple electronic databases, manual search, and contacting the authors by e-mail if needed. Studies will be selected according to the predefined criteria and the data collected on study participants, interventions, control groups, outcome measurements, their results, adverse events, and risk of bias will be summarized. The primary outcome will be the disease activity score (including effective rate, swollen joint count, tender joint count, and morning stiffness), and the secondary outcomes will be blood tests (including erythrocyte sedimentation rate, C-reactive protein, and rheumatoid factor) and adverse events. We will use Review Manager software to perform a meta-analysis, the Cochrane Collaboration “risk of bias” tool for assessing the risk of bias, and grades of recommendation, assessment, development and evaluation for the determination of the quality of evidence.

Trial registration number:

https://inplasy.com; INPLASY202230026.

Results:
We are going to investigate the effectiveness and safety of SXD for RA.

Conclusion:
This study will provide reliable evidence on whether SXD is effective on RA.