bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant peroxisome proteostasis—establishing, renovating, and dismantling the peroxisomal proteome
Authors: Muhammad DurreShahwar , Smith Kathryn A. , Bartel Bonnie 
Published: June 2022

Abstract
Plant peroxisomes host critical metabolic reactions and insulate the rest of the cell from reactive byproducts. The specialization of peroxisomal reactions is rooted in how the organelle modulates its proteome to be suitable for the tissue, environment, and developmental stage of the organism. The story of plant peroxisomal proteostasis begins with transcriptional regulation of peroxisomal protein genes and the synthesis, trafficking, import, and folding of peroxisomal proteins. The saga continues with assembly and disaggregation by chaperones and degradation via proteases or the proteasome. The story concludes with organelle recycling via autophagy. Some of these processes as well as the proteins that facilitate them are peroxisome-specific, while others are shared among organelles. Our understanding of translational regulation of plant peroxisomal protein transcripts and proteins necessary for pexophagy remain based in findings from other models. Recent strides to elucidate transcriptional control, membrane dynamics, protein trafficking, and conditions that induce peroxisome turnover have expanded our knowledge of plant peroxisomal proteostasis. Here we review our current understanding of the processes and proteins necessary for plant peroxisome proteostasis—the emergence, maintenance, and clearance of the peroxisomal proteome.
IoT based thermal aware routing protocols in wireless body area networks: Survey: IoT based thermal aware routing in WBAN
Authors: Jalili Marandi Shabnam , Golsorkhtabaramiri Mehdi , Hosseinzadeh Mehdi , Jafarali Jassbi Somayyeh 
Published: June 2022

AbstractThe growth of the world's population, especially that of the elderly, along with the outbreak of infectious diseases such as COVID‐19 have caused hospitals and healthcare centres to become full, and even economical treatments cost a lot. On that account, the conjunction of wireless body area networks (WBAN) and Internet of Things (IoT) for healthcare and medical diagnosis has become really important, and is accordingly one of the most popular and attractive areas of the Internet of Things (IoT). In such an IoT, a wireless body area network (WBAN) consists of a miniature sample of the Internet of Medical Things (IoMT) that can be either implanted in the human body or wearable. Nowadays, IoT has made healthcare evaluation possible. Instead of the patient being constantly hospitalized for treatment, the condition of the person is sent to the health centre by the IoMT over the Internet. IoT enables wireless communication between smart devices on one side and almost anything on the other. Since this network deals with medical and critical conditions, data must be sent to a physician or practitioner in the prescribed period; this indicates that routing is one of the most critical issues. Thus, routing is considered a very important challenge in WBANs. The present study describes thermal (temperature)‐aware routing protocols in WBANs. Routing protocols in WBANs are divided into thermal (temperature)‐aware, QoS‐aware, security‐aware, cluster‐based, cross‐layered, postured‐based, cost‐effect, link‐aware, and opportunistic ones. In a WBAN, temperature rise in implant nodes can damage body tissues, which is dangerous for the patient. Accordingly, here, those algorithms were considered which are presented in thermal (temperature)‐aware protocols. This paper first introduces IoT‐based WBANs, their routing mechanism and challenges, after which it provides a detailed description of thermal (temperature)‐aware algorithms. Finally, the advantages and disadvantages of these algorithms are presented.
Fast charging load guidance strategy based on adjustable charging service fee
Authors: Zhang Meixia , Zhang Qianqian , Yang Xiu , Sun Quanjie 
Published: June 2022

AbstractAiming at solving the problem of the deterioration of the voltage quality of the distribution network caused by the fast charging load of large‐scale electric vehicles, a fast charging load guidance strategy based on adjustable tiered charging service fees is proposed to guide users to adopt the charging location decision with the least comprehensive charging cost, and then balance the charging load distribution of each charging station to improve the voltage quality of the distribution network. Firstly, considering the constraints of the regional road network and distribution network, a fast charging load forecasting model based on the trip chain theory and Monte Carlo method is established; secondly, a regional tiered charging service fee adjustment model is constructed with the optimization goal of minimizing the absolute sum of node voltage deviations of distribution network; then, the user charging location weighted decision model with the least comprehensive cost of charging service fee, trip time and road power consumption is constructed. Finally, from the calculation, it can be seen that the adjustable tiered charging service fees can more effectively guide users to change the charging location, thus improving voltage quality and reducing pressure on grid capacity.
Comparison of Risk of Serious Cardiovascular Events after Hemorrhagic versus Ischemic Stroke: A Population-Based Study
Authors: Akyea Ralph K. , Georgiopoulos Georgios , Iyen Barbara , Kai Joe , Qureshi Nadeem , Ntaios George 
Published: June 2022

Abstract
Background Patients with ischemic stroke are considered a very high risk population for subsequent cardiovascular events and guidelines recommend intensive preventive strategies. However, there is no clear recommendation that patients with hemorrhagic stroke should also be regarded as a very high cardiovascular risk population.
Objective To compare the risk of subsequent cardiovascular morbidity/mortality between patients with incident hemorrhagic and ischemic stroke.
Methods Patients aged ≥18 years with incident hemorrhagic or ischemic stroke between 1998 and 2017 and no prior history of serious vascular event were identified from UK Clinical Practice Research Datalink (CPRD GOLD) linked to Hospital Episode Statistics data.
Results The cohort included 32,091 patients with an overall follow-up of 381,237 person-years (median: 11.8 years). After adjusting for potential confounders, patients with incident hemorrhagic stroke had no significantly different risk of subsequent cardiovascular morbidity compared with patients with incident ischemic stroke—coronary heart disease (CHD; hazard ratio [HR]: 0.86, 95% confidence interval [CI]: 0.56–1.32), recurrent stroke (HR: 0.92, 95% CI: 0.83–1.02), peripheral vascular disease (PVD; HR: 1.15, 95% CI:0.56–2.38), or heart failure (HR: 1.03, 95% CI: 0.61–1.74). Patients with incident hemorrhagic stroke had significantly higher risk of subsequent cardiovascular disease (CVD)-related mortality (HR: 2.35, 95% CI: 2.04–2.72) and all-cause mortality (HR: 2.16, 95% CI: 1.94–2.41). Propensity-score matched analysis of 1,039 patients with hemorrhagic stroke and 1,039 with ischemic stroke showed similar risk in subsequent cardiovascular morbidity—CHD (stratified HR [sHR]: 0.92, 95% CI: 0.55–1.54), recurrent stroke (sHR: 0.93, 95% CI: 0.82–1.02), PVD (sHR: 1.04 95% CI: 0.45–2.41), or heart failure (sHR: 0.71, 95% CI: 0.39–1.27).
Conclusion The risk of subsequent cardiovascular events is similar between patients with incident hemorrhagic and ischemic stroke. Patients with previous hemorrhagic stroke should be regarded as a population at very high risk for subsequent CVD.
Adverse Events and All-Cause Mortality in Danish Patients with Cerebral Venous Thrombosis: A Nationwide Cohort Study
Authors: Ording Anne Gulbech , Skjøth Flemming , Andersen Søren Due , Larsen Torben Bjerregaard 
Published: June 2022

AbstractBackground Cerebral venous thrombosis (CVT) is a rare manifestation of stroke and venous thromboembolism (VTE), compared with deep vein thrombosis (DVT) and pulmonary embolism (PE). We examined whether CVT was associated with adverse cardiovascular events.Methods A Danish cohort study with adult patients diagnosed with CVT (N = 1,015) between 1997 and 2017. We matched 10 patients with VTE (DVT and PE) to each patient with CVT for age, sex, and diagnosis year. We also matched 10 individuals from the general population to each patient with CVT. We computed cumulative incidence and estimated hazard ratios (HRs) with 95% confidence intervals (95% CIs) at 5 years for major bleeding, intracranial bleeding, ischemic stroke, and cardiovascular events. Death was examined separately.Results Major bleeding risks were 1.2% for CVT and 0.7% for VTE at 6 months; these risks increased to 2.7% and 2.6%, respectively, at 5 years. Although rare, intracranial bleeding risks were markedly higher for CVT (2.9%) than for VTE (0.4%) at 5 years (HR = 8.9, 95% CI: 5.3–15.1). Incidences of ischemic stroke were 5.9% for CVT and 0.3% for VTE, at 6 months; and 10.0% and 1.4%, respectively, at 5 years (HR = 9.5, 95% CI: 7.1–12.7). In contrast, incidence of cardiac events was lower for CVT that VTE (1.7% vs. 3.6% at 5 years). Mortality risk was higher after CVT compared with VTE, at 6 months (6.6% vs. 3.8%), but the risks differed little at 5 years (14.3% vs. 14.1%).Conclusion Intracranial bleeding, ischemic stroke, and mortality risks were higher for patients with CVT than matched patients with VTE and the general population, particularly within 6 months after diagnosis.
Flow Cytometric Expression of CD49d in Newly Diagnosed Chronic Lymphocytic Leukemia and Its Correlation with Established Prognostic Markers
Authors: Kunnumbrath Arathi , Singh Neha , Gupta Arvind Kumar , Chowdhury Nilotpal , Nath Uttam Kumar , Chandra Harish 
Published: June 2022

Abstract
Introduction Chronic lymphocytic leukemia (CLL) is the commonest hematological malignancy in the West but is relatively uncommon in India. The prognosis of CLL is determined by well-established prognostic markers. CD49d has been emerging as a promising prognostic marker in CLL. CD49d expression in CLL has been found to have an aggressive clinical course, shorter time to first treatment, and poorer prognosis. The aim of this study was to analyze the flow cytometric expression of CD49d in newly diagnosed CLL and to correlate its expression with clinico-hematological parameters.
Materials and Methods Twenty-five consecutive patients of CLL, diagnosed on flow cytometry, were included in the study. Patients on treatment or those with relapse were excluded. The panel for flow cytometry included the routine markers used for CLL diagnosis along with CD49d. The expression of CD49d was correlated with clinico-hematological parameters in all patients. “R” software was used for the statistical analysis. Fisher's exact test and Wilcox test were used to assess the correlation of CD49d to categorical and continuous data, respectively.
Results The mean age of the patients was 62.6 ± 12.5 years, and 80% were symptomatic at diagnosis. CD49d expression was found in 44% cases, with a higher proportion being male patients. CD49d and prolymphocyte percentage showed a statistically significant correlation (p = 0.0007). We found a statistically significant correlation between CD49d expression and lymphadenopathy and splenomegaly with p-values of 0.033 and 0.0472, respectively. CD49d positivity correlated significantly with a higher Rai stage (p = 0.0196) and intermediate and high-risk cases according to Binet staging (p = 0.033).
Conclusion CD49d expression in the present study correlated with a higher prolymphocyte percentage, lymphadenopathy, splenomegaly, and higher Rai and Binet stages. CD49d expression on flow cytometry was reproducible and easy to interpret.
Resistance of sugarcane varieties to smut (
Authors: Bhuiyan Shamsul A. , Stringer Joanne K. , Croft Barry J. , Olayemi Muyiwa E. 
Published: June 2022

Aims and methods An experiment was established in Australia in 2008 with 34 varieties of sugarcane, to determine disease development over the crop classes, and the relationship between resistance category and yield loss from sugarcane smut. Key results Yield loss was related to incidence and disease severity in different varieties. Susceptible varieties had > 40% smut infected plants in the plant crop whereas little smut infection was observed on intermediate and resistant varieties. Smut disease across all varieties increased from 5% incidence and 7% severity in the plant crop to 46% and 19% incidence and severity respectively in the first ratoon (first regrowth crop) and to 59% and 27% incidence and severity respectively in the second ratoon (second regrowth) crops. Strong negative correlations were observed for smut incidence (r = −0.57) and severity (r = −0.62) with cane yield in the second ratoon crop. For every percent of increase in smut incidence and severity, a loss of 574 kg and 756 kg of cane per hectare were estimated, respectively. Similarly, the losses of tonnes of sugar per hectare were estimated to 96 kg and 128 kg for each 1% increase in smut incidence and smut severity. Conclusion Regression analysis showed that yield loss can be reduced from > 40% for susceptible varieties to < 6% for resistant varieties. Implications A relationship of different resistance categories and yield loss due to sugarcane smut has been established to develop a guide for growers in selecting appropriate varieties for a particular agroclimatic zone.
Climate-aware decision-making: lessons for electric grid infrastructure planning and operations
Authors: Brockway Anna M , Wang Liyang , Dunn Laurel N , Callaway Duncan , Jones Andrew 
Published: June 2022

Abstract
Climate change poses significant risks to large-scale infrastructure systems and brings considerable uncertainties that challenge historical planning approaches. Here we focus on how climate awareness might be better incorporated into planning and decision-making in the electric power sector. To do so, we consider lessons from decision science literature where researchers have specifically focused on how to make better decisions under uncertainty. We perform a three-part review: of decision science literature on best practices for decision-making under uncertainty, of industry practice documents to understand how new uncertainties may affect the types of decisions electric utilities are making today, and of literature on electricity sector planning under climate change to assess how lessons from decision science might fit into sector-specific analyses. We discuss how characterizations of uncertainty from the decision science literature might guide approaches in the electricity sector to appropriately capture climate-related uncertainties. We also distill three key ideas from the decision science literature that can be incorporated into electricity sector planning to manage these new uncertainties: robustness, adaptive planning, and multi-stakeholder engagement. We offer example recommendations for how these key ideas might be incorporated into one essential type of planning activity, capacity expansion.
Psychological Stress Management and Stress Reduction Strategies for Stroke Survivors: A Scoping Review
Authors: Hinwood Madeleine , Ilicic Marina , Gyawali Prajwal , Coupland Kirsten , Kluge Murielle G , Smith Angela , Bowden Sue , Nilsson Michael , Walker Frederick Rohan 
Published: June 2022

Abstract

Background
Stroke can be a life-changing event, with survivors frequently experiencing some level of disability, reduced independence, and an abrupt lifestyle change. Not surprisingly, many stroke survivors report elevated levels of stress during the recovery process, which has been associated with worse outcomes.

Purpose
Given the multiple roles of stress in the etiology of stroke recovery outcomes, we aimed to scope the existing literature on stress management interventions that have been trialed in stroke survivors.

Methods
We performed a database search for intervention studies conducted in stroke survivors which reported the effects on stress, resilience, or coping outcome. Medline (OVID), Embase (OVID), CINAHL (EBSCO), Cochrane Library, and PsycInfo (OVID) were searched from database inception until March 11, 2019, and updated on September 1, 2020.

Results
Twenty-four studies met the inclusion criteria. There was significant variation in the range of trialed interventions, as well as the outcome measures used to assess stress. Overall, just over half (13/24) of the included studies reported a benefit in terms of stress reduction. Acceptability and feasibility were considered in 71% (17/24) and costs were considered in 17% (4/24) of studies. The management of stress was rarely linked to the prevention of symptoms of stress-related disorders. The overall evidence base of included studies is weak. However, an increase in the number of studies over time suggests a growing interest in this subject.

Conclusions
Further research is required to identify optimum stress management interventions in stroke survivors, including whether the management of stress can ameliorate the negative impacts of stress on health.
Discrimination, Mediating Psychosocial or Economic Factors, and Antihypertensive Treatment: A 4-Way Decomposition Analysis in the Health and Retirement Study
Authors: Sims Kendra D , Batty G David , Smit Ellen , Hystad Perry W , McGregor Jessina C , Odden Michelle C 
Published: June 2022

Abstract
Untested psychosocial or economic factors mediate associations between perceived discrimination and suboptimal antihypertensive therapy. This study included 2 waves of data from Health and Retirement Study participants with self-reported hypertension (n = 8,557, 75% non-Hispanic White, 15% non-Hispanic Black, and 10% Hispanic/Latino) over 4 years (baselines of 2008 and 2010, United States). Our primary exposures were frequency of experiencing discrimination, in everyday life or across 7 lifetime circumstances. Candidate mediators were self-reported depressive symptoms, subjective social standing, and household wealth. We evaluated with causal mediation methods the interactive and mediating associations between each discrimination measure and reported antihypertensive use at the subsequent wave. In unmediated analyses, everyday (odds ratio (OR) = 0.86, 95% confidence interval (CI): 0.78, 0.95) and lifetime (OR = 0.91, 95% CI: 0.85, 0.98) discrimination were associated with a lower likelihood of antihypertensive use. Discrimination was associated with lower wealth, greater depressive symptoms, and decreased subjective social standing. Estimates for associations due to neither interaction nor mediation resembled unmediated associations for most discrimination-mediator combinations. Lifetime discrimination was indirectly associated with reduced antihypertensive use via depressive symptomatology (OR = 0.99, 95% CI: 0.98, 1.00). In conclusion, the impact of lifetime discrimination on the underuse of antihypertensive therapy appears partially mediated by depressive symptoms.
Comparative Effectiveness of Direct-Acting Antivirals for Posttraumatic Stress Disorder in Veterans Affairs Patients With Hepatitis C Virus Infection
Authors: Shiner Brian , Huybrechts Krista , Gui Jiang , Rozema Luke , Forehand Jenna , Watts Bradley V , Jiang Tammy , Hoyt Jessica E , Esteves Jack , Schnurr Paula P , Ray Kristen , Gradus Jaimie L 
Published: June 2022

Abstract
We recently conducted an exploratory study that indicated that several direct-acting antivirals (DAAs), highly effective medications for hepatitis C virus (HCV) infection, were also associated with improvement in posttraumatic stress disorder (PTSD) among a national cohort of US Department of Veterans Affairs (VA) patients treated between October 1, 1999, and September 30, 2019. Limiting the same cohort to patients with PTSD and HCV, we compared the associations of individual DAAs with PTSD symptom improvement using propensity score weighting. After identifying patients who had available baseline and endpoint PTSD symptom data as measured with the PTSD Checklist (PCL), we compared changes over the 8–12 weeks of DAA treatment. The DAAs most prescribed in conjunction with PCL measurement were glecaprevir/pibrentasvir (GLE/PIB; n = 54), sofosbuvir/velpatasvir (SOF/VEL; n = 54), and ledipasvir/sofosbuvir (LDV/SOF; n = 145). GLE/PIB was superior to LDV/SOF, with a mean difference in improvement of 7.3 points on the PCL (95% confidence interval (CI): 1.1, 13.6). The mean differences in improvement on the PCL were smaller between GLE/PIB and SOF/VEL (3.0, 95% CI: −6.3, 12.2) and between SOF/VEL and LDV/SOF (4.4, 95% CI: −2.4, 11.2). While almost all patients were cured of HCV (92.5%) regardless of the agent received, PTSD outcomes were superior for those receiving GLE/PIB compared with those receiving LDV/SOF, indicating that GLE/PIB may merit further investigation as a potential PTSD treatment.
Seed macro- and micromorphology in Allium (Amaryllidaceae) and its phylogenetic significance
Authors: Yusupov Ziyoviddin , Ergashov Ibrokhimjon , Volis Sergei , Makhmudjanov Dilmurod , Dekhkonov Davron , Khassanov Furkat , Tojibaev Komiljon , Deng Tao , Sun Hang 
Published: June 2022

Abstract

Background and Aims
Macro- and micromorphology of seeds are diagnostic characteristics of importance in delimiting taxa in Allium (Amaryllidaceae). However, there is no consensus on the phylogenetic significance of testa cell characteristics and whether they reflect the different evolutionary levels recognized in Allium.

Methods
Seeds of 95 species (98 samples) representing 14 subgenera and 58 sections of Allium were examined using scanning electron microscopy (SEM) for such traits as periclinal wall surface area of ten testa cells, distance between testa cells (macromorphology), testa cell shapes, and arrangement and structure of anticlinal and periclinal walls (micromorphology). The data matrix was subjected to cladistic analysis. The produced phylogenetic tree was examined against the molecular tree obtained from publically available ITS sequences.

Key Results
The periclinal wall surface area of ten testa cells and the distance between them, examined for the first time, were found useful for delimitation of species in Allium. Based on seed macro- and micromorphology, we present a taxonomic key and a hypothetical reconstruction of the migration routes during the early stages of evolution of Allium.

Conclusions
The ancestors of Allium originated in an area bounded by the Caucasus, Central Asia and Iran. The seed testa morphology-based evolutionary state of a species is determined by two parameters: the shape of the periclinal walls and curvature of the anticlinal walls.