bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Deep Temporal Arteries: Anatomical Study with Application to Augmentations Procedures of the Temple
Authors: Bae Hyungkyu , Choi You‐Jin , Lee Kyu‐Lim , Gil Young‐Chun , Hu Kyung‐Seok , Kim Hee‐Jin 
Published: September 2022

AbstractThe aim of this study was to determine the anatomical features of the deep temporal arteries (DTAs) and thereby provide clinical information for the temple augmentation procedure. Forty‐two adult hemifaces from 15 Korean and 6 Thai cadavers (12 males, 9 females; mean age at death, 79.6 years) with no history of trauma or surgical procedure on the temple area were used for anatomical study. A detailed dissection was performed to identify the locations of the anterior and posterior deep temporal arteries (ADTA and PDTA) with reference to the vertical plane passing through the zygomatic tubercle. Fifty‐eight healthy Korean participants (31 males and 27 females; mean age, 24.7 years) were included in the ultrasonographic study. The distance from the bone to the DTAs was measured at the level of the zygomatic tubercle (HZt) and the eyebrow (HEb). The DTAs were not found within 7.2–12.6 mm posterior to the zygomatic tubercle; instead, the locations varied widely at the HEb. The distances between the bone and the ADTA were 1.7 ± 1.2 mm (mean ± SD) and 1.3 ± 0.8 mm, and those between the bone and the PDTA were 2.1 ± 1.2 mm and 2.0 ± 1.4 mm at HZtand HEb, respectively. Our findings indicate that at HZt, the area 1 cm posterior to the zygomatic tubercle may be a safe area for deep temple augmentation procedures. However, because the distribution patterns of the DTAs at HEband depth of the DTAs are variable, additional care is required to minimize the risks of the procedure.
Clinical applications of mucogingival therapies utilizing adjunctive autologous blood products
Authors: Geisinger Maria L. , Kaur Maninder , Abou Arraj Ramzi V. , Basma Hussein , Geurs Nicolaas C. 
Published: September 2022

AbstractBackgroundMucogingival deformities are prevalent oral conditions and can result in esthetic compromise, dentinal hypersensitivity, and an increase in radicular caries rates. Mucogingival treatments address thin periodontal phenotype and/or gingival recession defects. Although many of these grafting procedures are predictable in improving soft‐tissue quality and quantity around teeth and dental implants, patients often complain of discomfort at both the donor and recipient sites. Free gingival grafts and coronally advanced flaps alone or in combination with subepithelial connective tissue graft and/or acellular dermal matrix are among the most common surgical procedures employed to achieve root coverage and enhance periodontal phenotype. Autologous blood products (ABPs) contain platelets, growth factors, leukocytes, and stem cells that contribute to cell mitosis, collagen production, and angiogenesis, leading to the healing and regeneration of hard and soft tissue. Evaluation of the adjunctive role of ABPs in mucogingival surgery and their impacts on clinical and patient‐centered data is critical to achieve optimal patient‐reported outcome measures based upon the current scientific evidence.MethodsWe present exemplar cases in which adjunctive ABPs were utilized in mucogingival treatment to enhance treatment outcomes.ResultsNo adverse events were noted. Satisfactory treatment outcomes were achieved in patients with local and/or systemic compromise when mucogingival therapies were used in combination with ABPs.ConclusionsAdjunctive use of ABPs may enhance outcomes of mucogingival therapy. Utilization of adjunctive ABPs may be particularly advantageous in situations where the predictability of clinical and esthetic outcomes is limited due to anatomical and/or patient factors.
Identification of Dihydroorotate Dehydrogenase Inhibitors Using the Cell Painting Assay
Authors: Schölermann Beate , Bonowski Jana , Grigalunas Michael , Burhop Annina , Xie Yusheng , Hoock Joseph G. F. , Liu Jie , Dow Mark , Nelson Adam , Nowak Christine , Pahl Axel , Sievers Sonja , Ziegler Slava 
Published: September 2022

AbstractProfiling approaches have been increasingly employed for the characterization of disease‐relevant phenotypes or compound perturbation as they provide a broad, unbiased view on impaired cellular states. We report that morphological profiling using the cell painting assay (CPA) can detect modulators of de novo pyrimidine biosynthesis and of dihydroorotate dehydrogenase (DHODH) in particular. The CPA can differentiate between impairment of pyrimidine and folate metabolism, which both affect cellular nucleotide pools. The identified morphological signature is shared by inhibitors of DHODH and the functionally tightly coupled complex III of the mitochondrial respiratory chain as well as by UMP synthase, which is downstream of DHODH. The CPA appears to be particularly suited for the detection of DHODH inhibitors at the site of their action in cells. As DHODH is a validated therapeutic target, the CPA will enable unbiased identification of DHODH inhibitors and inhibitors of de novo pyrimidine biosynthesis for biological research and drug discovery.
Evidence for Multiple Binding Modes in the Initial Contact Between SARS‐CoV‐2 Spike S1 Protein and Cell Surface Glycans**
Authors: Parafioriti Michela , Ni Minghong , Petitou Maurice , Mycroft‐West Courtney J. , Rudd Timothy R. , Gandhi Neha S. , Ferro Vito , Turnbull Jeremy E. , Lima Marcelo A. , Skidmore Mark A. , Fernig David G. , Yates Edwin A. , Bisio Antonella , Guerrini Marco , Elli Stefano 
Published: September 2022

AbstractInfection of host cells by SARS‐CoV‐2 begins with recognition by the virus S (spike) protein of cell surface heparan sulfate (HS), tethering the virus to the extracellular matrix environment, and causing the subunit S1‐RBD to undergo a conformational change into the ‘open’ conformation. These two events promote the binding of S1‐RBD to the angiotensin converting enzyme 2 (ACE2) receptor, a preliminary step toward viral‐cell membrane fusion. Combining ligand‐based NMR spectroscopy with molecular dynamics, oligosaccharide analogues were used to explore the interactions between S1‐RBD of SARS CoV‐2 and HS, revealing several low‐specificity binding modes and previously unidentified potential sites for the binding of extended HS polysaccharide chains. The evidence for multiple binding modes also suggest that highly specific inhibitors will not be optimal against protein S but, rather, diverse HS‐based structures, characterized by high affinity and including multi‐valent compounds, may be required.
Light‐Responsive Oligothiophenes Incorporating Photochromic Torsional Switches
Authors: Jozeliūnaitė Augustina , Rahmanudin Aiman , Gražulis Saulius , Baudat Emilie , Sivula Kevin , Fazzi Daniele , Orentas Edvinas , Sforazzini Giuseppe 
Published: September 2022

AbstractWe present a quaterthiophene and sexithiophene that can reversibly change their effective π‐conjugation length through photoexcitation. The reported compounds make use of light‐responsive molecular actuators consisting of an azobenzene attached to a bithiophene unit by both direct and linker‐assisted bonding. Upon exposure to 350 nm light, the azobenzene undergoes trans‐to‐cis isomerization, thus mechanically inducing the oligothiophene to assume a planar conformation (extended π‐conjugation). Exposure to 254 nm wavelength promotes azobenzene cis‐to‐trans isomerization, forcing the thiophenic backbones to twist out of planarity (confined π‐conjugation). Twisted conformations are also reached by cis‐to‐trans thermal relaxation at a rate that increases proportionally with the conjugation length of the oligothiophene moiety. The molecular conformations of quaterthiophene and sexithiophene were characterized by using steady‐state UV‐vis spectroscopy, X‐ray crystallography and quantum‐chemical modeling. Finally, we tested the proposed light‐responsive oligothiophenes in field‐effect transistors to probe the photo‐induced tuning of their electronic properties.
Inhibitory Effect of DMSO on Halohydrin Dehalogenase: Experimental and Computational Insights into the Influence of an Organic Co‐solvent on the Structural and Catalytic Properties of a Biocatalyst
Authors: Milčić Nevena , Stepanić Višnja , Crnolatac Ivo , Findrik Blažević Zvjezdana , Brkljača Zlatko , Majerić Elenkov Maja 
Published: September 2022

AbstractInvited for the cover of this issue are Zlatko Brkljača, Maja Majerić Elenkov and co‐workers at the Ruđer Bošković Institute and University of Zagreb. The image depicts the enzyme halohydrin dehalogenase HheC, which is made up of four identical subunits, with marked catalytic residues and volumetric maps of water and DMSO in the active site. Read the full text of the article at 10.1002/chem.202201923.
Preparation of nano titanium dioxide coatings by anodic oxidation: beautifully colorful and functional
Authors: Lanfermann Philipp , Weidmann Christoph , Waitz Stefanie , Maaß Mona Christin , Waitz Thomas 
Published: September 2022

AbstractIm vorliegenden Beitrag wird eine für den Chemieunterricht geeignete elektrochemische Methode zur Herstellung von nano‐ und mikrometerdicken TiO2‐Schichten auf Titanblechen vorgestellt. Durch Variation der Synthesebedingungen lassen sich dabei gezielt verschieden farbig erscheinende kompakte sowie poröse Schichten herstellen. Letztere eignen sich als Photokatalysatoren sowie als Elektrodenmaterial für Natrium‐Ionen‐Akkus, wozu ebenfalls Experimente vorgestellt werden. Neben den Versuchen werden für den Chemieunterricht geeignete Modelle präsentiert, mit denen sich die Ursachen der Farbigkeit durch Interferenz an dünnen Schichten sowie das Wachstum farbiger und poröser TiO2‐Schichten durch Wanderung von Ionen im Festkörper verstehen lassen. Abschließend werden thematische Anknüpfungspunkte der Experimente für den Chemie‐ und für den fächerübergreifenden Unterricht diskutiert.
Data attribute oriented business process effective infrequency behavior mining method
Authors: Li Juan , Fang Xianwen , Guo Xin , Liu Yuzhou , Agordzo George K. 
Published: September 2022

SummaryThe current process mining method takes high‐frequency behavior as the mainstream behavior, and directly filters out the infrequent logs as noise to obtain a concise business process model. However, effective infrequency behaviors that are important to business processes are often data constrained. From a control flow perspective, it is difficult to accurately capture the effective infrequency behavior. A method for mining effective infrequent behaviors based on data attributes is proposed to solve the above problems. First, the important data attributes of target business processes are obtained by feature combination. Then, attribute assignment rules are set according to the needs of the business process to determine whether it has a beneficial impact on the business process. Lastly, it is suggested that a confidence interval be used instead of the traditional threshold to evaluate and mine effective low‐frequency behavior. The experiment results show that compared with other methods, it can significantly improve the fitness of the business process model and can more accurately mine effective infrequency behavior to optimize the business process model.
Use of 5,10‐Disubstituted Dibenzoazaborines and Dibenzophosphaborines as Cyclic Supports of Frustrated Lewis Pairs for the Capture of CO2
Authors: Ferrer Maxime , Alkorta Ibon , Elguero Jose , Oliva‐Enrich Josep M. 
Published: September 2022

AbstractThe front cover artwork is provided by Prof. Ibon Alkorta′s group at the Instituto de Química Médica (CSIC) and Instituto de Química‐Física Rocasolano (CSIC). The image shows the ability of the 5,10‐Disubstituted Dibenzophosphaborines to capture CO2. Depending on the substituents placed on the Lewis acid and base, the reaction profile of this cyclic Frustrated Lewis Pair changes. Read the full text of the Research Article at 10.1002/cphc.202200204.
Tuning the Carrier Transfer Behavior of Coaxial ZnO/ZnS/ZnIn2S4Nanorods with a Coherent Lattice Heterojunction Structure for Photoelectrochemical Water Oxidation
Authors: Peng Jing , Liu Guorui , Jiao Xianhui , Xia Hongqiang , Li Jing , Ma Qingxiang , Jin Jun , Li Feng 
Published: September 2022

AbstractSerious degradation and the short photogenerated carrier lifetime for the wide‐bandgap semiconductor ZnO have become prominent issues that negatively affect photoelectrochemical (PEC) water splitting. Herein, a novel electron transport pathway was constructed by simple but effective coaxial growth of ZnO/ZnS/ZnIn2S4heterostructure nanoarrays to increase the carrier separation efficiency. This new photoanode fulfilled the requirements of both favorable band alignment and stability, achieving a stable photocurrent density of 1.146 mA cm−2at 1.2 VRHE, which was approximately twice that of pristine ZnO. Detailed experimental studies revealed that the improved PEC activity was due to the lattice‐matching interface coherency that activated the carrier transport pathway, giving rise to an optimized interfacial electronic structure for promoted charge separation by the built‐in electric field and strengthened water oxidation activity. This design may provide a new approach to fabricating various efficient lattice‐matching coherent interface photoanodes for PEC water splitting.
Across the Board: Rui Cao on Electrocatalytic CO2 Reduction
Authors: Cao Rui 
Published: September 2022

AbstractIn this series of articles, the Board Members of ChemSusChem review recent research articles that they consider of exceptional quality and importance for sustainability. This entry features Prof. Rui Cao, who discusses how tuning the second‐sphere environments of Fe porphyrins can improve the activity and selectivity for CO2 reduction. Substituents with proton relay capability, hydrogen‐bonding, and electrostatic features have significant impact on the efficiency of Fe porphyrins for the electrocatalytic CO2 reduction reaction
Signal in the noise: Dimensions of predictability in the home auditory environment are associated with neurobehavioral measures of early infant sustained attention
Authors: Werchan Denise M. , Brandes‐Aitken Annie , Brito Natalie H. 
Published: September 2022

AbstractThe home auditory environment influences the development of early language abilities, and excessive noise exposure is increasingly linked with deficits in language and reading scores in children. However, fewer studies have considered the role of noise exposure in shaping the development of attentional processing in early infancy, a foundational neurocognitive skill relevant for learning. Here, we used passive at‐home auditory recording to investigate how multiple dimensions of infants’ home auditory environments, including both the quantity and the predictability of auditory input, impacts neural and behavioral measures of sustained attention in a sociodemographically diverse sample of 3‐month‐old infants (N = 98 infants, 62 males; age M = 3.48 months, SD = 0.39; 52% Hispanic/Latino). Results indicated that infants who were exposed to more predictable patterns of auditory input in the home demonstrated longer overall time in sustained attention during laboratory assessments. In addition, infants’ who experienced more predictable auditory input also demonstrated greater relative increases in electroencephalography frontal theta power during periods of sustained attention, a neural marker relevant to information processing and attentional control. These findings provide novel evidence into the importance of the predictability of early environmental inputs in shaping developing cortical circuitry and attentional systems from the first months of postnatal life.
The physiology of maternal sensitivity to distress: An exploratory study of mothers’ electrocortical and sympathetic nervous system reactivity
Authors: Frost Allison , Kuzava Sierra , Bernard Kristin 
Published: September 2022

AbstractMaternal sensitivity in response to infant distress is related to a number of physiological processes, including electrocortical activity and activation of the sympathetic nervous system. Several studies have examined these systems in isolation, but limited work to date has investigated how they may moderate one another in relation to maternal behavior. The current exploratory study aimed to investigate the interactive effect of the late positive potential (LPP) and skin conductance level (SCL) on observed maternal sensitivity to distress. Ninety‐five mothers of 6‐ to 12‐month‐old infants participated in two reactivity tasks measuring their LPP and SCL responses to child crying stimuli. Maternal sensitivity to distress was coded from video‐recorded mother–infant interactions. Results showed a significant interaction effect, such that LPP reactivity to infant crying was positively related to maternal sensitivity to distress among mothers with relatively low SCL reactivity. The findings highlight the importance of examining multiple systems when characterizing the physiological basis of maternal behavior.
The history of natural history and race: Decolonizing human dimensions of ecology
Authors: Miriti Maria N. , Rawson Ariel J. , Mansfield Becky 
Published: September 2022

AbstractNatural history, loosely defined as the observational study of organisms in the habitats where they occur, is recognized at the roots of ecology. Although the centrality of natural history in ecology has shifted over time, natural history is currently in resurgence: many again consider it to be the foundation of ecological and evolutionary inquiry and advocate the value of organism‐centered approaches to address contemporary ecological challenges. Educators identify natural history as the foundational entryway into the practice of ecology, for example in the Ecological Society of America's Four‐Dimensional Ecology Education (4DEE) framework. A strong natural history foundation can help generate testable hypotheses to refine mechanistic understanding of the drivers regulating species distributions and abundances and to inform restoration and conservation efforts. Given the resurgence of natural history as the foundation for ecological knowledge and practice, it is important to recognize that natural history has a long history of racism that has impacted ecological thought and priorities. This history shapes not only who conducts ecological science but also foundational ecological concepts. For example, natural history's emphasis on pristine nature untouched by humans disregards or appropriates stewardship and knowledge of most of the world's population. Because of the legacy of chattel slavery, this exclusion is particularly strong for people of African descent. This exclusion narrows ecological inquiry, limits the capacity to find solutions to ecological problems, and risks interventions that perpetuate the relation between eugenics, ecological knowledge, and natural systems. If ecology is to become an inclusive, responsive, and resilient discipline, this knowledge gap must be addressed. We here present the colonial and racist underpinnings of natural history and offer strategies to expand inclusion in the study of nature. Natural history was steeped in racism, providing a hierarchy of cultures and a taxonomy of races. Complementing growing interest in traditional and Indigenous ecological knowledge, we focus on Black ecological knowledge, for example in the study of “maroon ecologies.” Addressing the racist history of natural history is necessary for removing structural and racist barriers to diverse participation and expanding ecological knowledge bases in service of better and more just science.
Redefining American conservation for equitable and inclusive social‐environmental management
Authors: Morales Nia , Lee Jordan , Newberry Milton , Bailey Karen 
Published: September 2022

AbstractEfforts to recruit, retain, and include Blacks, Indigenous, and People of Color (BIPOC) in environmental fields often fall short, in part due to limited conceptualizations of conservation and environment. At the core of this is the North American Model for Wildlife Conservation, an important approach to conservation and wildlife management that has influenced conservation globally. This model, however, is based upon a specific subset of worldviews, driven by Western and Eurocentric constructions of wilderness and nature. This model creates a narrow view of human–environment relationships and erases cultures and communities that explicitly view themselves as part of nature. We review the seven tenets of the North American Model for Wildlife Conservation, highlighting their limitations and exclusion of other models of environmental and natural resource management and alternative relationships with nature. In order to support long‐term environmental engagement and culturally responsive research, 21st century environmental practitioners should shift our thinking around conservation to center counter narratives of BIPOC communities, scientists, and professionals as part of and meaningfully connected to nature. We argue that relying solely on the historically dominant language and ideologies at the core of the North American Model perpetuates disparities in environmental engagement and limits retention of BIPOC in environmental fields. We further highlight how shifts in understanding conservation and relationships to nature enables us to re‐frame our work to support equitable, inclusive, and just conservation science and practice.
Environmental DNA reveals anadromous river herring habitat use and recolonization after restoration of aquatic connectivity
Authors: Ogburn Matthew B. , Plough Louis V. , Bangley Charles W. , Fitzgerald Catherine L. , Hannam Michael P. , Lee Benjamin , Marafino Gabriella , Richie Kimberly D. , Williams Meghan R. , Weller Donald E. 
Published: September 2022

AbstractRestoring and sustaining anadromous fish populations is a grand challenge in the conservation of freshwater ecosystems. Alewife Alosa pseudoharengus and Blueback Herring Alosa aestivalis are two closely related anadromous fish for which responses to fish passage restoration are poorly known. We used a targeted environmental DNA method to sample 17 major tributaries of the Chesapeake Bay, USA, to determine the spatial extent of habitat use during the spawning season and the associations of habitat use with watershed characteristics. To help understand responses to restoration of fish passage, the study included portions of eight watersheds where dam removals, fish ladders, or dam failures provided access to habitats that were previously inaccessible to anadromous fish. Overall, 27.5% of samples showed positive detections for river herring, including at least one sample in 16 of 17 tributaries sampled. The presence of both species combined was negatively associated with elevation (relative influence [RI] = 29.8%) and positively associated with a watershed area (RI = 14.5%) and percent cropland (13.6%) of the watershed. In species‐specific analyses, both Alewife (RI = 24.8%) and Blueback Herring (26.2%) presence was negatively associated with elevation, Alewife were more common in watersheds with high percentages of cropland (RI = 19.1%), whereas Blueback Herring were more common in streams with large watersheds (23.2%). The use of formerly blocked spawning habitats was generally greater upstream of sites where dams were removed (2%–100% of habitat used) compared with sites where fish ladders were installed (0%–66.8% of habitat used). The broad‐scale sampling enabled by eDNA methods made it possible to identify habitat use patterns that can be applied to prioritize future restoration efforts and predict species‐specific responses.