bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene Therapy, A Potential Therapeutic Tool for Neurological and Neuropsychiatric Disorders: Applications, Challenges and Future Perspective
Authors: Mani Shalini , Jindal Divya , Singh Manisha 
Published: March 2022

Abstract:
Neurological and neuropsychiatric disorders are the main risks for the health care system,
exhibiting a huge socioeconomic load. The available range of pharmacotherapeutics mostly provides
palliative consequences and fails to treat such conditions. The molecular etiology of various neurological
and neuropsychiatric disorders is mostly associated with a change in genetic background, which
can be inherited/triggered by other environmental factors. To address such conditions, gene therapy is
considered a potential approach claiming a permanent cure of the disease primarily by deletion, silencing,
or edition of faulty genes and by insertion of healthier genes. In gene therapy, vectors (viral/nonvial)
play an important role in delivering the desired gene to a specific region of the brain. Targeted
gene therapy has unraveled opportunities for the treatment of many neurological and neuropsychiatric
disorders. For improved gene delivery, the current techniques mainly focus on designing a precise viral
vector, plasmid transfection, nanotechnology, microRNA, and in vivo clustered regulatory interspaced
short palindromic repeats (CRISPR)-based therapy. These latest techniques have great benefits
in treating predominant neurological and neurodevelopmental disorders, including Parkinson's disease,
Alzheimer's disease, and autism spectrum disorder, as well as rarer diseases. Nevertheless, all these
delivery methods have their limitations, including immunogenic reactions, off-target effects, and a deficiency
of effective biomarkers to appreciate the effectiveness of therapy. In this review, we present a
summary of the current methods in targeted gene delivery, followed by the limitations and future direction
of gene therapy for the cure of neurological and neuropsychiatric disorders.
Halal Food Analysis Using FTIR Spectroscopy Combined with
Chemometrics: A Review
Authors: Ahda Mustofa , Guntarti Any 
Published: March 2022

Abstract:
Halal is an important part that was clearly regulated by Holy Qur’an and Al-Hadith. This regulation is intended to safeguard our lives, especially for Muslims. The prohibited things can present various problems arise. However, Halal is a good choice for long-term life and safer for us. Therefore, this review explains the basis of the halal analysis and the use of FTIR as one of the analytical methods in halal foods. The basis of the halal analysis involves the specified non-halal contents, where they will encourage the developed analytical methods for halal authentications. Many analytical methods developed in halal analysis include gas chromatography (GC)/gas chromatography mass spectroscopy (GC-MS), high pressure liquid chromatography (HPLC), fourier transform infra red (FTIR), electronic nose (e-nose), real-time polymerase chain reaction (RT-PCR), etc. Based on this review, FTIR spectroscopy combined with chemometrics is a good method for halal food analysis because it provides an appropriate result and it is a simple method and a non destructive preparation.
Analysis of CNN and Feed-Forward ANN Model for the Evaluation of
ECG Signal
Authors: Mathur Prerak , Sharma, Tanu , Veer Karan 
Published: March 2022

Aims:
Heart disease is considered as one of the complex diseases that has affected a large number of people around world.

Background:
Therefore, it is important to detect and identify cardiac diseases at early stages

Objective:
A large number of methods are already present that detect various heart diseases, however, there are some limitations in these methods that degraded their overall performance.

Methods:
In this paper, an effective and efficient method based on convolutional neural network (CNN) and feed forward artificial neural network (FFANN) is proposed that can effectively detect cardiac diseases after analysing the Electrocardiogram (ECG) signals. In this ongoing study, the transformed signals are used to extract the information from the processed data. The extracted features are then passed to the proposed CNN-FFANN classifiers for training and testing purpose.

Results:
The performance of the proposed CNN-FFANN model is evaluated in the MATLAB software in terms of performance matrices.

Conclusion:
The simulated outcomes proved that the proposed CNN-FFANN model is more accurate and efficient in detecting heart diseases from ECG signals and can be adopted for future biomedical applications.
Exploring the Potential of IL-1β Inhibitor Diacerein and its Combination
with 5-aminosalicylic Acid for the Possible Ameliorating Effect in TNBSinduced
Experimental Colitis in Wistar Rats
Authors: Roy Supriya , Dhaneshwar Suneela , Mahmood Tarique 
Published: March 2022

Background:
Pro-inflammatory mediators such as tumor necrosis factor-alpha (TNF-α),
interleukin (IL), and oxidative stress are crucial players in the pathophysiology of inflammatory bowel
disease (IBD) that contribute to perpetuating intestinal inflammation. Targeting them presents a novel
approach to disease management. In the present study, the potential of an antiosteoarthritic ILinhibitor
drug, diacerein (DIA), was investigated in 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)- instigated
ulcerative colitis (UC) in Wistar rats. A comparative study was also undertaken to investigate
the potential of combination therapy of DIA with the standard drug 5-aminosalicylic acid (5-ASA)
versus monotherapy.

Methods:
Colitis was developed by single intra-colonic administration of TNBS (100mg/kg); whereas
drugs 5-ASA (25.5 mg/kg), DIA (100 mg/kg), and DIA+5-ASA (100 + 25.5 mg/kg) were administered
orally for five days post-induction to various groups of rats. Parameters like disease activity score, colon/
body weight ratio, colon length, diameter, and gut pH were assessed, and histopathological analysis
was carried out. Biochemical markers of colonic inflammation such as IL-1β, TNF-α, reduced glutathione
(GSH), and malondialdehyde (MDA) were also estimated.

Results:
Combination of DIA and 5-ASA demonstrated the most significant reduction of the colon to
body weight ratio and disease activity score. It prominently restored the colon length, diameter, and
gut pH to normal. It attenuated the biochemical alterations induced by TNBS, indicating a highly significant
defensive outcome against colonic inflammation. The histopathological report demonstrated
the renovating effect of the combination of disrupted colonic histology with minimally distressing liver,
stomach, or pancreas compared to individual drugs.

Conclusion:
The combination remarkably downregulated the level of inflammation by suppressing
both provocative cytokines and reactive oxygen species production. It can be evaluated further used in
a clinical setup as a novel and promising drug therapy for UC.
A Safe and Novel Outpatient Subcutaneous Vitamin B12 Desensitization
Protocol in A Patient with Crohn’s Disease and Vitamin B12 Allergy: A
Case Report
Authors: Fajt Merritt L. , Meerbeke Sara W. Van , Petrov Andrej A. , Barrie Arthur M. 
Published: March 2022

Introduction:
Although rare, some patients may have a vitamin B12 allergy. Crohn’s
disease commonly leads to significant vitamin B12 deficiency, especially in those patients that
have undergone ileal resection. In these difficult cases, vitamin B12 desensitization may be required.

Case Presentation:
Here, we report a successful case of a serial outpatient subcutaneous vitamin
B12 desensitization protocol in a 35-year-old female with a past medical history of Crohn’s disease
status post ileal resection, subsequent vitamin B12 deficiency, and allergy to subcutaneous vitamin
B12.

Conclusion:
This is the first subcutaneous vitamin B12 desensitization protocol reported to have
been safely performed in the outpatient setting.
A Personalized Ontology-Based Decision Support System for Complex Chronic Patients: Retrospective Observational Study
Authors: Román-Villarán Esther , Alvarez-Romero Celia , Martínez-García Alicia , Escobar-Rodríguez German Antonio , García-Lozano María José , Barón-Franco Bosco , Moreno-Gaviño Lourdes , Moreno-Conde Jesús , Rivas-González José Antonio , Parra-Calderón Carlos Luis 
Published: March 2022

Background
Due to an increase in life expectancy, the prevalence of chronic diseases is also on the rise. Clinical practice guidelines (CPGs) provide recommendations for suitable interventions regarding different chronic diseases, but a deficiency in the implementation of these CPGs has been identified. The PITeS-TiiSS (Telemedicine and eHealth Innovation Platform: Information Communications Technology for Research and Information Challenges in Health Services) tool, a personalized ontology-based clinical decision support system (CDSS), aims to reduce variability, prevent errors, and consider interactions between different CPG recommendations, among other benefits.

Objective
The aim of this study is to design, develop, and validate an ontology-based CDSS that provides personalized recommendations related to drug prescription. The target population is older adult patients with chronic diseases and polypharmacy, and the goal is to reduce complications related to these types of conditions while offering integrated care.

Methods
A study scenario about atrial fibrillation and treatment with anticoagulants was selected to validate the tool. After this, a series of knowledge sources were identified, including CPGs, PROFUND index, LESS/CHRON criteria, and STOPP/START criteria, to extract the information. Modeling was carried out using an ontology, and mapping was done with Health Level 7 Fast Healthcare Interoperability Resources (HL7 FHIR) and Systematized Nomenclature of Medicine Clinical Terms (SNOMED CT; International Health Terminology Standards Development Organisation). Once the CDSS was developed, validation was carried out by using a retrospective case study.

Results
This project was funded in January 2015 and approved by the Virgen del Rocio University Hospital ethics committee on November 24, 2015. Two different tasks were carried out to test the functioning of the tool. First, retrospective data from a real patient who met the inclusion criteria were used. Second, the analysis of an adoption model was performed through the study of the requirements and characteristics that a CDSS must meet in order to be well accepted and used by health professionals. The results are favorable and allow the proposed research to continue to the next phase.

Conclusions
An ontology-based CDSS was successfully designed, developed, and validated. However, in future work, validation in a real environment should be performed to ensure the tool is usable and reliable.
An Assessment of the Potential Benefits of Video Consultation in the Emergency Department: Mixed Methods Study
Authors: Turner Jane , Clarke Malcolm , George Grizelda , Jones Russell Wynn , Pullinger Rick , Kharbanda Rajesh , Kennedy James , Hands Linda 
Published: March 2022

Background
District general hospital emergency departments may refer patients to a tertiary center depending on the information available to a generalist clinician in discussion with a specialist team. If there is uncertainty, the lowest-risk strategy is often to transfer the patient. Video consultation allowing the specialist team to see and talk to the patient and local clinician while still in the emergency department could improve decision-making for patient transfer.

Objective
The aim of this study is to assess the potential benefit of real-time video consultation between remote specialists and emergency department patients and clinicians across all specialties.

Methods
Detailed patient data were collected prospectively for 6 months (between January 16, 2012, and July 15, 2012) on all patients presenting to a district general hospital emergency department who required input from a specialist team at the nearest tertiary care center. These patients were discussed retrospectively with the specialist teams to determine whether videoconferencing could have benefited their management. The logistics for the use of videoconferencing were explored.

Results
A total of 18,799 patients were seen in the emergency department during the study period. Among the 18,799 patients, 413 referrals (2.2%) were made to the tertiary center specialist teams. A review of the patients transferred indicated that 193 (46.7%) of the 413 patients who were referred might have benefited from video consultation (193/18,799, 1% of all patients). If the specialist team could be accessed via videoconferencing only while a senior member was available in the hospital (8:00 AM-10:00 PM), then a maximum of 5 patients per week across all specialties would use the equipment. If 24-hour specialist access was available, this would increase to 7 patients per week.

Conclusions
In regions where there is direct transportation of patients by ambulance to specialist centers and there is a regional picture archiving and communication system in place, video consultation between emergency department patients and specialists has limited potential to improve patient management.
The Incidence of Adult-Onset Type 1 Diabetes: A Systematic Review From 32 Countries and Regions
Authors: Harding Jessica L. , Wander Pandora L. , Zhang Xinge , Li Xia , Karuranga Suvi , Chen Hongzhi , Sun Hong , Xie Yuting , Oram Richard A. , Magliano Dianna J. , Zhou Zhiguang , Jenkins Alicia J. , Ma Ronald C.W. 
Published: March 2022

BACKGROUND
The epidemiology of adult-onset type 1 diabetes (T1D) incidence is not well-characterized due to the historic focus on T1D as a childhood-onset disease.

PURPOSE
We assess the incidence of adult-onset (≥20 years) T1D, by country, from available data.

DATA SOURCES
A systematic review of MEDLINE, Embase, and the gray literature, through 11 May 2021, was undertaken.

STUDY SELECTION
We included all population-based studies reporting on adult-onset T1D incidence and published from 1990 onward in English.

DATA EXTRACTION
With the search we identified 1,374 references of which 46 were included for data extraction. Estimates of annual T1D incidence were allocated into broad age categories (20–39, 40–59, ≥60, or ≥20 years) as appropriate.

DATA SYNTHESIS
Overall, we observed the following patterns: 1) there is a paucity of data, particularly in low- and middle-income countries; 2) the incidence of adult-onset T1D is lowest in Asian and highest in Nordic countries; 3) adult-onset T1D is higher in men versus women; 4) it is unclear whether adult-onset T1D incidence declines with increasing age; and 5) it is unclear whether incidence of adult-onset T1D has changed over time.

LIMITATIONS
Results are generalizable to high-income countries, and misclassification of diabetes type cannot be ruled out.

CONCLUSIONS
From available data, this systematic review suggests that the incidence of T1D in adulthood is substantial and highlights the pressing need to better distinguish T1D from T2D in adults so that we may better assess and respond to the true burden of T1D in adults.
Droner i sivilsamfunnet: Aktører, teknologi og etiske utfordringer
Authors: Gynnild Astrid 
Published: March 2022

Civil drones are about to become a billion industry in Norway, and they are often touted as Norway´s new oil. But what exactly do we mean by civil drones, and how can we best ensure that they are used responsibly in society? That is the main question to be discussed in this book. Drones in Civil Society elucidates the topic from many different perspectives. Who are the various actors involved, and how do they work together? What are the differences between civil and military uses of drones? How do we differentiate between the hobby pilot and the professional drone operator, and how can students be trained in responsible, experimental investigation of drone technology? And not least: What happens to the privacy protection of the individual citizen in the midst of all this? The escalating pace of development suggests that drones will soon be an integral part of our everyday lives. What are the implications of this new reality on transportation, business, nature, surveillance, privacy, crime, warfare, and communication?
Mortality due to COVID-19 and Risk Factors at Pachuca´s General Hospital in the State of Hidalgo, Mexico
Authors: Tenorio Pastrana Mario Alberto , Téllez Baca Luis Alberto , Soberanes Hernández Gloria del Pilar , Muñoz Juárez Sergio , Ríos Castañeda Maria Evodia , Mendoza Orta Erika , García Ríos José Daniel , Vázquez Josefina Reynoso , Hernández-Ceruelos Alejandra 
Published: March 2022

Aim: To estimate the risk of death secondary to COVID-19 infection and to identify the factors associated with these deaths at the Pachuca General Hospital, Hidalgo, Mexico.
Material and methods: The information was obtained from the daily report of patients whose were attended at Hospital Genera de Pachuca for respiratory disease compatible with COVID-19 from March 2020 to March 2021, the information obtained was captured electronically in a database by the epidemiology department of the institution. A cross-sectional design was used. Patients who died secondary to complications of respiratory disease were compared with survivors of the same disease. Pearson's Chi-square was used to estimate the differences between the deceased and the survivors. For the crude risk of dying from COVID-19, the odds ratio was used, and for the adjusted risk, non-conditional logistic regression was used, a trend analysis was performed, with the corresponding trend Chi-square test, all calculations were made with 95% confidence.
Results: The information of 4418 people with respiratory disease was analyzed. During the study period, 647 people died of COVID-19, corresponding to 14.64%. Of the population, 50.97% were men, their mortality was 18.92% and that of women was 10.22% (P <0.05). Variables associated with dying from complications from COVID-19 were found to be male (OR 2.05, 95% CI 1.71-2.45), being 40 years old or older (OR 9.62, 95% CI 7.30-12.86), having a positive RT-PCR result (OR 3.53 95% CI 2.83-4.43), and being a carrier of a Chronic Degenerative Disease (OR 4.79 95% CI 4.01-5.73).
Conclusions: The results indicate that the risk of dying from COVID-19 is related to male patients, at the older age of the patients, having a positive RT-PCR and suffering from at least one chronic degenerative disease.
Strămutarea şi desemnarea altei instanţe pentru judecarea cauzei în reglementarea procesual penală actualmente în vigoare
Authors: Volonciu Nicolae , Marin Cătălin 
Published: March 2022

În vederea desfăşurării în condiţii optime a procesului penal, este necesar să existe încredere cu privire la obiectivitatea şi imparţialitatea subiecţilor procesuali oficiali în activitatea de rezolvare a cauzei penale. În măsura în care se iveşte o suspiciune rezonabilă că imparţialitatea tuturor judecătorilor unei instanţe este afectată datorită împrejurărilor cauzei, calităţii părţilor ori atunci când există pericol de tulburare a ordinii publice, remediul procesual îl constituie instituţia strămutării.
Măsura strămutării presupune o derogare de la competenţa teritorială, determinând o deplasare de competenţă teritorială între instanţe de acelaşi grad şi de aceeaşi natură. Practic, instanţei competente teritorial prin raportare la regulile obişnuite i se substituie o instanţă delegată. În ceea ce priveşte obiectul acestui remediu procesual, considerăm că nu trebuie exclusă admisibilitatea unei cereri de strămutare a soluţionării unei cauze în cadrul unei proceduri judiciare, separate de judecarea fondului cauzei.
În anumite situaţii, temeiurile de natură a fundamenta strămutarea unei cauze penale pot fi cunoscute încă din cursul fazei prejurisdicţionale a urmăririi penale, ipoteză în care îşi poate găsi aplicabilitatea procedura desemnării altei instanţe pentru judecarea cauzei. Chiar dacă este prevăzută într-un text de lege distinct, aceasta nu reprezintă o nouă instituţie, ci se înfăţişează ca o modalitate specială de strămutare, care poate interveni anterior sesizării instanţei penale cu rechizitoriu.
PERANAN SEKTOR INDUSTRI TEKSTIL DAN PRODUK TEKSTIL (TPT)TERHADAP PEREKONOMIANINDONESIA: ANALISIS INPUT-OUTPUT
Authors: Fajri Taris , Triyowati Hermin 
Published: March 2022

This study aims to determine how well the number of direct and indirect linkages, index of power deployment and index of the degree of sensitivity as well as the multiplier output, income, and labor sectors of textiles and textile products within the scope of the Indonesian economy in 2005. To get the purpose of the study analysis, this research is done by analyzing the data on Indonesian Input-Output Table 175 sectors in 2005. Analyzed data from the Input-Output Table is a data transaction on the basis of domestic producer prices. These sectors are aggregated into 68 sectors. This is done to see the impact of deployment and linkage textiles and textile products to other sectors of the economy. In the analysis of data, fiber and yarn spinning industry has backward linkages value is smaller than the linkages in the future. Textile industry (fabric), the apparel industry (garment), and the other has a value of industrial textiles backward linkages greater than the relationship in the future. In the analysis of the spread of the power index, industrial fiber and yarn spinning, textile (cloth), industry apparel (garment), and the textile industry was able to increase the upstream sector growth or increase the output of other sectors that are used as inputs by industry sector itself because it has the power dispersion index value greater than one. Power dispersion index greater than one means that the sector is able to enhance the growth of the upstream sector. Analysis of the degree of sensitivity index, industrial textile (cloth), the apparel industry and textile industry can’t afford to encourage the production of the downstream sector which uses the input from the industrial sector as it has a degree of sensitivity index values ​​less than one. In the multiplier analysis, for the analysis of output multipliers, the apparel industry has the largest output multiplier of the other sub-sectors is equal to 2.4647. For household income multiplier, fiber and spinning sector has multiplier largest household income from other sub-sectors is equal to 0.1644. In the employment multiplier, fiber and spinning sector had the largest employment multiplier of other sub-sectors is equal to 0.0214. From the analysis of the data, it can be concluded that the textile and clothing sector is the sector that Indonesia was in a position downstream of where the sector is a sector that produces an output that is directly consumed by final consumers. If the Government can properly optimize the sector, then the sector of textiles and textile products may act as a puller outputs of upstream sectors