bluuebunny/crossref_metadata_2025_split huggingface dataset:
A detailed review and analysis of assembly line rebalancing problems
Authors: Çimen Tolga , Baykasoğlu Adil , Demirkol Akyol Sebnem 
Published: October 2022

Purpose
Various approaches and algorithms have been proposed since the 1950s to solve the assembly line (AL) balancing problem. These methods have established an AL configuration from the beginning. However, a prebalanced AL may have to be rebalanced in real life for many reasons, such as changes in the cycle time, production demand, product features or task operation times. This problem has increasingly attracted the interest of scientists in recent years. This study aims to offer a detailed review of the assembly line rebalancing problems (ALRBPs) to provide a better insight into the theoretical and practical applications of ALRBPs.

Design/methodology/approach
A structured database search was conducted, and 41 ALRBP papers published between 2005 and 2022 were classified based on the problem structure, objective functions, problem constraints, reasons for rebalancing, solution approaches and type of data used for solution evaluation. Finally, future research directions were identified and recommended.

Findings
Single model, straight lines with deterministic task times were the most studied type of the ALRBPs. Eighteen percent of the studies solved worker assignment problems together with ALRBP. Product demand and cycle time changes were the leading causes of the rebalancing need. Furthermore, seven future research opportunities were suggested.

Originality/value
Although there are many review studies on AL balancing problems, to the best of the authors’ knowledge, there have been no attempts to review the studies on ALRBPs.
The influence of supply chain immunity perceptions on COVID-19 vaccine willingness in supply chain professionals
Authors: Finkenstadt Daniel Joseph , Handfield Robert 
Published: October 2022

PurposeThis study examines the lack of confidence in the actions of the government and pharmaceutical companies during vaccine deployment. The authors introduce the concept of supply chain immunity. The authors test whether the perception of higher vaccine supply chain immunity leads to higher willingness to be vaccinated within the supply chain community.Design/methodology/approachThe authors utilize factor analysis and item response theory methods to develop a scale for measuring supply chain immunity. The original and psychometrically sound scale is tested via a structural equation model (SEM). Factor analysis and SEM use survey responses from two samples of 125 supply chain executives.FindingsSEM suggests that supply chain immunity perceptions are a strong predictor of overall supply chain confidence for COVID vaccines. Further, these perceptions, through supply chain confidence, indirectly impact individuals' self-reported willingness to personally accept a vaccine themselves.Originality/valueThis paper presents the concept of supply chain immunity perceptions that have not been used in the medical supply chain literature. This paper presents a first-of-a-kind scale for supply chain immunity perceptions utilizing nascent methods and demonstrates the constructs impact on vaccine program confidence and public willingness to participate.
Implementing business excellence models in Saudi nonprofit organizations and the impact of human resources availability
Authors: Salih Osama , Dolah Rozzeta 
Published: October 2022

PurposeThis study aims to help nonprofit organizations (NPOs) implement business excellence models (BEMs). The authors identify and rank critical success factors and barriers to implementing BEMs among NPOs in Saudi Arabia and investigate the impact of human resources availability on BEM implementation in these organizations.Design/methodology/approachBased on the review of relevant literature, the authors designed a questionnaire completed by 138 NPOs. Factor analysis was used to measure and rank the criticality of success factors and barriers to BEM implementation. A Kruskal–Wallis nonparametric test was conducted to compare answers across groups classified by the number of full-time employees in the organization.FindingsThe study identifies the five most critical success factors for implementing BEMs in Saudi NPOs: data analysis and reporting capabilities, effective organizational communication, implementation strategy and approach, use of benchmarking and adoption of a clear governance framework. The five most critical barriers to implementing BEMs are the lack of a culture of continuous improvement, organizational strategy, qualified employees, customer orientation and clear organizational roles and responsibilities. The number of full-time employees in Saudi NPOs does not significantly impact the success or failure of implementing BEMs.Originality/valueThis paper is a continuation of research that aims to increase BEM adoption among NPOs, including micro-NPOs, in Saudi Arabia and, by extension, other countries.
Evolution of predator–prey interactions during range expansion in an aquatic insect predator
Authors: Carbonell José A. , Wang Ying‐Jie , Sentis Arnaud , Stoks Robby 
Published: October 2022

Abstract

Many ectotherms are shifting their distributions polewards, which has been associated with the evolution of phenotypic traits and their thermal plasticity. Trophic interactions may determine the dynamics and ecological impact of range expansions. However, it is largely unknown how trait evolution in edge populations shapes trophic interactions.

We studied evolutionary changes in the short‐term (functional response) and long‐term predator–prey interactions between an aquatic insect predator (the damselfly Ischnura elegans) and its prey (the water flea Daphnia magna) during the predator's ongoing poleward range expansion in northern Europe.

Using a common‐garden warming experiment at 20 and 24°C we tested for differentiation between predator populations from edge and core regions in metabolic rate and functional response parameters, and used these empirical data to estimate the effects of range expansion on the short‐ and long‐term predator–prey interaction strengths.

Metabolic rates did not differ between populations from edge and core regions nor between rearing temperatures. Functional response parameters and their thermal plasticity showed signals of evolution during the range expansion. Attack rates did not differ between predators from edge and core regions, but only decreased under warming in predators from the edge region. Handling times decreased under warming in predators from the edge region but increased under warming in predators from the core region. While handling times were shorter in predators from the core region at 20°C, these did not differ between regions at 24°C. As a result, the short‐term interaction strength was higher for predators from the core region at 20°C, but not different between regions at 24°C. The predator–prey system from the edge region showed lower long‐term system stability at 20°C, but this region difference disappeared under warming because the edge region stability then increased.

Our results suggest that rapid evolution of functional response parameters during a predator's range expansion reduced the direct feeding impact on its prey and made the predator–prey system from the edge region more unstable, but not under warming. This provides rare evidence that functional responses can rapidly evolve during range expansions, potentially destabilizing food web dynamics.

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Estimates of nectar productivity through a simulation approach differ from the nectar produced in 24 h
Authors: Carisio Luca , Schurr Lucie , Masotti Véronique , Porporato Marco , Nève Gabriel , Affre Laurence , Gachet Sophie , Geslin Benoît 
Published: October 2022

Abstract

Nectar is a key resource for numerous insects. Despite its importance, nectar productivity has mainly been assessed using one sampling method, in which the volume of nectar produced by a flower is measured after 24 h of isolation from insects (‘measured 24 h volume’ hereafter). This method assumes that nectar removal by flower‐visiting insects does not affect nectar productivity. Hence, a linearity in the nectar production dynamic is assumed. The effect of nectar removal could lead to an actual volume of nectar produced per flower over 24 h being higher or lower than the measured 24 h volume. Whether the nectar productivity is influenced by insect activity still therefore needs to be assessed.

In a field experiment, we estimated the nectar production dynamics of lavender (Lavandula hybrida) and fennel (Foeniculum vulgare) flowers and tested whether they met the linearity assumption. Then, we developed a simulation model to identify how different scenarios of insect foraging activity: nectar removal rate (average and maximum), and flower‐selection strategies (random selection or rewarding flower selection) alter the estimated 24 h volume of nectar for both crops (‘estimated 24 h volume’ hereafter). Finally, we tested whether the estimated 24 h volume differed from the measured 24 h volume for both crops.

Lavender and fennel showed equal measured 24 h volume of nectar but the produced nectar volume over 6 h suggested that a flower of lavender was more productive than a flower of fennel. Both nectar production dynamics did not meet the assumption of linearity. The simulation models showed that the estimated 24 h volume increased with maximum nectar removal rate for lavender, and the opposite was found for fennel. Rewarding selection always increased the estimated 24 h volume for fennel while for lavender a positive effect was detected at average rate of nectar removal. We found that the estimated 24 h volume was always greater than the measured 24 h volume.

Our model demonstrated that the effect of insect foraging activity on flower's nectar productivity should be considered while estimating the resources produced by plants. As an alternative, measures of produced nectar volume in short time spans may be compared with the measured 24 h volume to check the reliability of this widespread method.

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Mapping critical mineral resources using airborne geophysics, 3D joint inversion and geology differentiation: A case study of a buried niobium deposit in the Elk Creek carbonatite, Nebraska, USA
Authors: Wei Xiaolong , Li Kenneth , Sun Jiajia 
Published: October 2022

ABSTRACTCritical minerals are an integral part of the energy transition because of their important and, sometimes irreplaceable, uses in solar panels, wind turbines, electrical vehicles, etc. Mapping critical mineral resources is, therefore, essential to achieving the net‐zero emission goal by 2050. We present a case study on using airborne geophysical data, borehole and physical property measurements to characterize the Elk Creek Carbonatite complex located in the southeast of Nebraska, USA. It hosts the largest known niobium deposit in the United States and contains a high level of rare earth element mineralization. Our goal is to develop a better understanding of the three‐dimensional structures and composition of the Elk Creek Carbonatite complex as well as its critical mineral resource potential. We performed three‐dimensional joint inversion of the airborne gravity gradiometry and magnetic data to produce structurally similar density and susceptibility models. We carried out geology differentiation, a process of classifying recovered physical property values into distinct units, and obtained a three‐dimensional quasi‐geology model for the Elk Creek Carbonatite complex. We identified 12 geologic units, each of which is characterized by a distinct range of physical property values. Our quasi‐geology model, especially Units 9 and 11, shows a remarkable consistency with the borehole assay measurements. Unit 9 is spatially coincident with the known niobium ore zone. Unit 11 represents a significant volume of highly dense and magnetic materials below the deepest boreholes. These materials are likely associated with unexplored niobium mineralization. Our study demonstrates the added value of three‐dimensional geophysical joint inversions and geology differentiation in the context of critical mineral exploration under a thick sedimentary overburden.
Do functional and phylogenetic nestedness follow the same mechanisms as taxonomic nestedness? Evidence from amphibians in the largest archipelago of China
Authors: Chen Chuanwu , Zhan Chengxiu , Wang Yanping 
Published: October 2022

Abstract

Nested subset pattern (nestedness) has been raised to explain the distribution of species on islands and habitat fragments for over 60 years. However, previous studies on nestedness focused on species richness and composition and overlooked the role of species traits and phylogeny in generating and explaining nestedness.

To address this gap, we sampled amphibians on 37 land‐bridge islands in the largest archipelago of China, the Zhoushan Archipelago, to explore nestedness as well as the underlying causal processes through three facets of diversity, that is, taxonomic, functional and phylogenetic diversity. The taxonomic nestedness was measured through organizing the species incidence matrix to achieve a maximum value, while the functional and phylogenetic nestedness were quantified by incorporating the similarity of species in terms of their ecological traits and phylogeny. We also obtained six island characteristics and seven species traits as predictors of nestedness.

Amphibian metacommunities were significantly nested in these three facets of diversity. When relating different predictors to nestedness, island area, habitat diversity and species traits were highly correlated with taxonomic nestedness. Moreover, island area and habitat diversity significantly influenced functional and phylogenetic nestedness. Therefore, the results support the selective extinction and habitat nestedness hypotheses.

Interestingly, although we did not observe significant influences of island isolation on taxonomic nestedness, functional and phylogenetic diversities were significantly higher than expected when matrices were ordered by increasing distance to mainland. The result suggests that there are more functionally and phylogenetically diverse species on less‐isolated islands, reflecting a selective colonization process overlooked by the traditional analysis of taxonomic nestedness.

Although the three facets of nestedness and underlying processes were largely congruent, we detected the distance‐related functional and phylogenetic nestedness for amphibian assemblages. Therefore, we highlight that a framework that simultaneously considers taxonomic, functional and phylogenetic nestedness can contribute to a complementary understanding of nestedness processes. In addition, it also improves our ability to conserve insular biodiversity from different perspectives.
Centralisation versus regionalisation: Designing the Sixth National Mental Health Plan
Authors: Rosenberg Sebastian , Lawson Kenny , Hickie Ian 
Published: October 2022

AbstractIn response to the recent Productivity Commission report into mental health, the previous Federal Government announced its intention to produce a new national agreement that lays the platform for Australia's sixth national mental health plan. It has been recommended mental health move to a more regional model of governance and planning, away from a centralised, top‐down approach, partly in response to broader reforms affecting health care, and partly in direct response to consistent inquiry evidence that the mental health system remains in crisis. The past 30 years of mental health planning have been centralised. Successive national plans set a broad framework, with real decisions about mental health funding and service allocation made in the health departments of our capital cities. Will the next plan sponsor or inhibit regionality in mental health planning? This paper assesses Australia's historical approach to health planning particularly as it affected mental health and the costs arising. In learning these lessons, we propose the necessary ingredients to facilitate a regional, innovative, and effective approach to decentralised planning, for better mental health outcomes. We cannot afford to replicate the failed planning approaches of the past.
A phase II, multicenter study of lazertinib as consolidation therapy in patients with locally advanced, unresectable, EGFR mutation‐positive non‐small cell lung cancer (stage III) who have not progressed following definitive, platinum‐based, chemoradiation therapy (PLATINUM trial)
Authors: Choi Juwhan , Lee Jeong Eun , Choi Chang‐Min , Oh In‐Jae , Lee Kye Young , Jang Tae Won , Lee Seung Hyeun , Kim Eun Young , Park Dong Won , Park Sun Hyo , Lee Sung Yong 
Published: October 2022

AbstractIntroductionThe PACIFIC study demonstrated that durvalumab consolidation therapy significantly improved progression‐free survival (PFS) and overall survival (OS) in patients with unresectable stage III non‐small cell lung cancer (NSCLC) after concurrent chemoradiotherapy (CCRT). However, there was no clinical benefit in both PFS and OS in epidermal growth factor receptor (EGFR) mutation‐positive patient groups in a post hoc exploratory analysis. Moreover, the clinical effects of immune checkpoint inhibitors (ICIs) in EGFR mutation‐positive stage IV NSCLC were demonstrated to be poor. Personalized treatment according to the mutation status is also required in stage III NSCLC. Lazertinib, a third‐generation EGFR tyrosine kinase inhibitor (TKI), is newly developed and approved for use in Korea.MethodsThis prospective, open, single‐arm, multicenter, phase II clinical trial aims to evaluate the efficacy and safety of lazertinib as a consolidative therapy after CCRT treatment in unresectable, EGFR mutation‐positive NSCLC stage III patients. The primary endpoint of this study is PFS, and the secondary endpoints are OS, objective response rate (ORR), duration of response (DoR), time to death or distant metastasis (TTDM), and safety profiles.DiscussionOur study may extend the indications for third‐generation EGFR‐TKIs to treat patients with stage III NSCLC. Moreover, using this drug to treat stage III NSCLC would emphasize the value of mutation analysis and personalized medicine.
Autophagy activation can partially rescue proteasome dysfunction‐mediated cardiac toxicity
Authors: Papanagnou Eleni‐Dimitra , Gumeni Sentiljana , Sklirou Aimilia D. , Rafeletou Alexandra , Terpos Evangelos , Keklikoglou Kleoniki , Kastritis Efstathios , Stamatelopoulos Kimon , Sykiotis Gerasimos P. , Dimopoulos Meletios A. , Trougakos Ioannis P. 
Published: October 2022

AbstractThe ubiquitin–proteasome pathway and its functional interplay with other proteostatic and/or mitostatic modules are crucial for cell viability, especially in post‐mitotic cells like cardiomyocytes, which are constantly exposed to proteotoxic, metabolic, and mechanical stress. Consistently, treatment of multiple myeloma patients with therapeutic proteasome inhibitors may induce cardiac failure; yet the effects promoted by heart‐targeted proteasome dysfunction are not completely understood. We report here that heart‐targeted proteasome knockdown in the fly experimental model results in increased proteome instability and defective mitostasis, leading to disrupted cardiac activity, systemic toxicity, and reduced longevity. These phenotypes were partially rescued by either heart targeted‐ or by dietary restriction‐mediated activation of autophagy. Supportively, activation of autophagy by Rapamycin or Metformin administration in flies treated with proteasome inhibitors reduced proteome instability, partially restored mitochondrial function, mitigated cardiotoxicity, and improved flies' longevity. These findings suggest that autophagic inducers represent a novel promising intervention against proteasome inhibitor‐induced cardiovascular complications.
Canine transmissible venereal tumor – From general to molecular characteristics: A review
Authors: Faro Thamirys A. S. , de Oliveira Edivaldo H. C. 
Published: October 2022

AbstractCancer is a group of complex diseases resulting from the accumulation of genetic and epigenetic changes affecting control and activity of several genes, especially those involved in cell differentiation and growth processes, leading to an abnormal proliferation. When the disease reaches an advanced stage, cancer can lead to metastasis in other organs. Interestingly, recent studies have shown that some types of cancer spread not only through the body, but also can be transmitted among individuals. Therefore, these cancers are known as transmissible tumors. Among the three types of transmissible tumors that occur in nature, the canine transmissible venereal tumor (CTVT) is known as the oldest cancer in the world, since it was originated from a single individual 11 000 years ago. The disease has a worldwide distribution, and its occurrence has been documented since 1810. The CTVT presents three types of cytomorphological classification: lymphocytoid type, mixed type, and plasmacytoid type, the latter being chemoresistant due to overexpression of theABCB1gene, and consequently increase of the P‐glycoprotein. More knowledge about the epidemiology and evolution of CTVT may help to elucidate the pathway and form of the global spread of the disease.
Students' performance in teaching neuroanatomy using traditional and technology‐based methods
Authors: Hadžiomerović Nedžad , Hadžiomerović Amina Isanović , Avdić Rizah , Muminović Adis , Tandir Faruk , Bejdić Pamela , Pandžić Adi 
Published: October 2022

AbstractThe use of digital teaching resources became widespread and very helpful during the COVID‐19 pandemic as an alternative to a traditional course with cadavers. Technologies such as augmented reality (AR), virtual reality (VR), 3D models, video lectures and other online resources enable three‐dimensional visualization of the anatomical structures and allow students to learn more interactively. The aim of this study was to compare students' performance in the traditional anatomical courses in teaching neuroanatomy and technology‐based learning methods such as video lectures, 3D models and 3D printed specimens. Four groups of first‐year students of Veterinary Faculty established for the practical classes during the academic year 2021/2022 took part in this research. The total number of students participating in this research was 72. Each group attended separately the theoretical lecture with a demonstration based on a different technique; the control group used formalized specimens, while the three experimental groups used video lectures, 3D models and 3D printed specimens, respectively. Subsequently, all groups completed the same questionnaire testing their short‐term memory of the neuroanatomical structures. After four weeks students were tested for their long‐term memory of the neuroanatomy lecture with the follow‐up test containing an identical list of questions. The test scores using video lectures and 3D printed models were significantly higher compared with the group that learned in the traditional way. This study suggests that alternative approaches such as technology‐based digital methods can facilitate memorization of anatomical terms and structures in a more interactive and sensory engaging way of learning.