bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Magnetically and Electrically Powered Hybrid Micromotor in Conductive Solutions: Synergistic Propulsion Effects and Label‐Free Cargo Transport and Sensing
Authors: Wu Yue , Yakov Sivan , Fu Afu , Yossifon Gilad 
Published: December 2022

AbstractElectrically powered micro‐ and nanomotors are promising tools for in vitro single‐cell analysis. In particular, single cells can be trapped, transported, and electroporated by a Janus particle (JP) using an externally applied electric field. However, while dielectrophoretic (DEP)‐based cargo manipulation can be achieved at high‐solution conductivity, electrical propulsion of these micromotors becomes ineffective at solution conductivities exceeding ≈0.3 mS cm−1. Here, JP cargo manipulation and transport capabilities to conductive near‐physiological (<6 mS cm−1) solutions are extended successfully by combining magnetic field‐based micromotor propulsion and navigation with DEP‐based manipulation of various synthetic and biological cargos. Combination of a rotating magnetic field and electric field results in enhanced micromotor mobility and steering control through tuning of the electric field frequency. In addition, the micromotor's ability of identifying apoptotic cell among viable and necrotic cells based on their dielectrophoretic difference is demonstrated, thus, enabling to analyze the apoptotic status in the single‐cell samples for drug discovery, cell therapeutics, and immunotherapy. The ability to trap and transport live cells towards regions containing doxorubicin‐loaded liposomes is also demonstrated. This hybrid micromotor approach for label‐free trapping, transporting, and sensing of selected cells within conductive solutions opens new opportunities in drug delivery and single‐cell analysis, where close‐to‐physiological media conditions are necessary.
Triple A‐Site Cation Mixing in 2D Perovskite‐Inspired Antimony Halide Absorbers for Efficient Indoor Photovoltaics
Authors: Lamminen Noora , Grandhi Gopal Krishnamurthy , Fasulo Francesca , Hiltunen Arto , Pasanen Hannu , Liu Maning , Al‐Anesi Basheer , Efimov Alexander , Ali‐Löytty Harri , Lahtonen Kimmo , Mäkinen Paavo , Matuhina Anastasia , Muñoz‐García Ana Belén , Pavone Michele , Vivo Paola 
Published: December 2022

AbstractAntimony‐based perovskite‐inspired materials (PIMs) are solution‐processable halide absorbers with interesting optoelectronic properties, low toxicity, and good intrinsic stability. Their bandgaps around 2 eV make them particularly suited for indoor photovoltaics (IPVs). Yet, so far only the fully inorganic Cs3Sb2ClxI9−x composition has been employed as a light‐harvesting layer in IPVs. Herein, the first triple‐cation Sb‐based PIM (CsMAFA‐Sb) in which the A‐site of the A3Sb2X9 structure consists of inorganic cesium alloyed with organic methylammonium (MA) and formamidinium (FA) cations is introduced. Simultaneously, the X‐site is tuned to guarantee a 2D structure while keeping the bandgap nearly unchanged. The presence of three A‐site cations is essential to reduce the trap‐assisted recombination pathways and achieve high performance in both outdoor and indoor photovoltaics. The external quantum efficiency peak of 77% and the indoor power conversion efficiency of 6.4% are the highest values ever reported for pnictohalide‐based photovoltaics. Upon doping of the P3HT hole‐transport layer with F4‐TCNQ, the power conversion efficiency of CsMAFA‐Sb devices is fully retained compared to the initial value after nearly 150 days of storage in dry air. This work provides an effective compositional strategy to inspire new perspectives in the PIM design for IPVs with competitive performance and air stability.
Overall Improvement in Dielectric, Water Resistance and Mechanical Properties of Polyimide Film via Synergy between GO and Sandwich‐type Porous Structure
Authors: Han Yuhang , Ma Yingyi , Zhang Junming , Yao Shun , Xu Kaizheng 
Published: December 2022

AbstractSimultaneous improvement in dielectric, water resistance and mechanical properties of polyimide (PI) films is critical for their practical use, but difficult to achieve. Herein, a sandwich‐type porous GO/PI film with excellent comprehensive properties was obtained through integrating a GO‐containing complex, fluorine‐containing porous structure and sandwich‐type distribution of porous structure by a simple, low‐cost and green breath figure method. With the addition of only a small amount of GO‐containing complex, a low dielectric constant of 2.21, water absorption of 0.51%, increment in dielectric constant after moisture treatment of 1.60% and high tensile strength of 113.1 MPa, tensile modulus of 1.70 GPa, with 35.39%, 79.42%, 81.81% of reduction and 17.22%, 21.43% of increase compared to PI film were shown, respectively. Moreover, these properties could be adjusted through regulating the component and porous structure by changing the parameters of breath figure method. These outstanding properties make the film a promising candidate for high‐performance low‐dielectric materials.
Statistical inference for a Wiener‐based degradation model with imperfect maintenance actions under different observation schemes
Authors: Leroy Margaux , Bérenguer Christophe , Doyen Laurent , Gaudoin Olivier 
Published: December 2022

AbstractThis paper studies the statistical inference in a degradation model with imperfect maintenance. Technological or industrial devices subject to degradation undergo maintenance actions that reduce their degradation level. The underlying degradation process is a Wiener process with drift. Maintenance effects are assumed to be imperfect, described by an Arithmetic Reduction of Degradation () model. The system is regularly inspected and the degradation levels are measured. Four different observation schemes are considered so that degradation levels can be observed between maintenance actions as well as just before or just after maintenance times. The paper studies the estimation of the model parameters under the four observation schemes. Maximum likelihood estimators are derived for each scheme. The quality of the estimations is assessed and the observation schemes are compared through an extensive simulation and performance study.
Advances in Selective Electrocatalytic Hydrogenation of Alkynes to Alkenes
Authors: Liu Zhenpeng , Zhang Lei , Ren Zhipeng , Zhang Jian 
Published: December 2022

AbstractSelective electrochemical hydrogenation of alkynes to alkenes under ambient conditions is a promising alternative to the traditional energy‐intensive and high‐cost thermocatalytic hydrogenation. However, the systematic summary on the electrocatalysts and electrolyzers remains lacked. Herein, we demonstrate a comprehensive review about recent achievements in the electrocatalysts including noble metal and non‐noble‐metal materials. Several effective strategies of catalyst design were developed to improve alkyne conversion, and alkene selectivity, for example, accelerating the formation of active hydrogen species, enhancing alkyne adsorption and suppressing the side reactions. Furthermore, the advantages and disadvantages of various electrolyzers are systematically discussed. Accordingly, major challenges and future trends in this field are proposed.
Brønsted Acid/Base Site Isolated in a Pentanuclear Scaffold
Authors: Tomoda Misa , Kondo Mio , Izu Hitoshi , Masaoka Shigeyuki 
Published: December 2022

AbstractThe concept of Brønsted‐Lowry acids and bases is long and widely recognized as the most reasonable theory to explain the behavior of H+ ions. Here, we report a Brønsted acid/base pair that does not follow this theory. Two heteronuclear metal complexes, in which Brønsted acid/base sites are sterically isolated, were synthesized and characterized. These sterically isolated sites exhibited anomalous behavior, wherein the H+ species encapsulated in the Brønsted acid site did not undergo a deprotonation reaction, and the corresponding protonation reaction at the Brønsted base site failed to proceed. As a result, two states that are in a relationship of a Brønsted acid/base pair stably exist over a wide pH range without any interconversion, generating a thermodynamically metastable state. Additionally, these two states exhibited distinct electron transfer abilities and reactivities. The system presented in this study is in sharp contrast with the traditional concept of Brønsted–Lowry acids and bases.
Femtosecond Spectroscopy and Quantum Chemistry of a Linearly Coordinated Copper(I) Carbene Complex
Authors: Nolden Oliver , Kremper Jennifer , Haselbach Wiebke , Morshedi Mahbobeh , Guhl Jasper , Schmeinck Philipp , Marian Christel M. , Ganter Christian , Gilch Peter 
Published: December 2022

AbstractLinearly coordinated copper(I) carbene complexes, such as [1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene]‐(2‐picoline)copper(I) tetrafluoroborate (1), exhibit promising photophysical properties with regard to organic light emitting diode (OLED) applications. Their emission characteristics strongly depend on the surrounding (crystal, matrix, and solution). Here, the behavior of 1 in solution is scrutinized by steady state as well as femtosecond spectroscopy. In coordinating solvents, like acetonitrile and alcohols, 1 is shown to bind solvent molecules as ligands. In non‐coordinating solvents, femtosecond UV/Vis absorption spectroscopy reveals a tri‐exponential decay with time constants of 0.3 ps, 900 ps, and 0.7 μs. The time constants are assigned with the aid of quantum chemistry. A more complex decay is observed in coordinating solvents.
Photoelectrochemical C−H Activation Through a Quinacridone Dye Enabling Proton‐Coupled Electron Transfer
Authors: Yang Yunshuo , Volpato Giulia Alice , Rossin Elena , Peruffo Nicola , Tumbarello Francesco , Nicoletti Catia , Bonetto Ruggero , Paoloni Lorenzo , Umari Paolo , Colusso Elena , Dell'Amico Luca , Berardi Serena , Collini Elisabetta , Caramori Stefano , Agnoli Stefano , Sartorel Andrea 
Published: December 2022

AbstractDye‐sensitized photoanodes for C−H activation in organic substrates are assembled by vacuum sublimation of a commercially available quinacridone (QNC) dye in the form of nanosized rods onto fluorine‐doped tin oxide (FTO), TiO2, and SnO2 slides. The photoanodes display extended absorption in the visible range (450–600 nm) and ultrafast photoinduced electron injection (<1 ps, as revealed by transient absorption spectroscopy) of the QNC dye into the semiconductor. The proton‐coupled electron‐transfer reactivity of QNC is exploited for generating a nitrogen‐based radical as its oxidized form, which is competent in C−H bond activation. The key reactivity parameter is the bond‐dissociation free energy (BDFE) associated with the N⋅/N−H couple in QNC of 80.5±2.3 kcal mol−1, which enables hydrogen atom abstraction from allylic or benzylic C−H moieties. A photoelectrochemical response is indeed observed for organic substrates characterized by C−H bonds with BDFE below the 80.5 kcal mol−1 threshold, such as γ‐terpinene, xanthene, or dihydroanthracene. This work provides a rational, mechanistically oriented route to the design of dye‐sensitized photoelectrodes for selective organic transformations.
Undernutrition and associated factors among lactating mothers in rural Yilmana Densa District, Northwest Ethiopia: A community‐based cross‐sectional study
Authors: Wubetie Biruk Yazie , Mekonen Tigist Kefale 
Published: December 2022

AbstractUndernutrition is continued to be significant public health problem worldwide. The extra calories and nutrients required to support breastfeeding make lactating mothers at higher risk of malnutrition than general population. Undernourished lactating mothers have also been found to influence both the quantity and quality of breast milk and then the nutritional and health status of their offspring. Different evidence showed that undernutrition among lactating mothers is a serious public health problem in Ethiopia in which one of every four lactate mothers are undernourished. Despite this fact, the prevalence of undernutrition among lactating women in Ethiopian was not well investigated and very limited number of studies are conducted. This study aims to assess the prevalence of undernutrition and associated factors among lactating mothers in rural Yilmana Densa District, Northwest Ethiopia. A community‐based cross‐sectional study was conducted among 428 lactating mothers. The data were collected by using interviewers administered structured questionnaire; and also, anthropometric measurements were taken from the study participants. Binary logistic regression model was undertaken to identify significantly associated factors with undernutrition. The prevalence of undernutrition among lactating mothers was 22.6%. Household income, food security status, dietary diversity score, number of meals, potable water source, and latrine facility were found to be significantly associated with undernourishment of lactating mothers. A significant proportion of lactating mothers in the district suffered from undernutrition and hence, to improve nutritional status of lactating mothers, strategies should focus on nutrition counseling, advancing diversified production and consumption, improvement of access to potable water and latrine, as well as effective household food security interventions.
Endometriosis, the Silent Disease: Molecular Targets, Active Principles, and Drug Delivery Systems
Authors: Teworte Sarah , Luciani Paola 
Published: December 2022

AbstractIn this perspective, we provide a broad overview of pathophysiological processes involved in endometriosis, including the role of inflammation, fibrosis, angiogenesis, hormonal regulation, and genetic factors. For each of the functional changes involved with the etiology of the disease, we showcase a selection of active principles in various stages of preclinical and clinical development. Finally, we highlight the role of drug delivery for endometriosis, particularly oral vs. vaginal administration. In doing so, we wish to draw the community's attention to this debilitating disease and highlight the need for interdisciplinary approaches to endometriosis treatment development.
Impact of the COVID‐19 pandemic on hospitalizations of children with neurologic impairment
Authors: Thomson Joanna , Richardson Troy , Auger Katherine A. , Brady Patrick W. , Hall Matt , Hartley David , Schondelmeyer Amanda C. , Shah Samir S. 
Published: December 2022

AbstractIntroductionChildren with neurologic impairment (NI) are frequently hospitalized for infectious and noninfectious illnesses. The early period of the COVID‐19 pandemic was associated with overall lower pediatric hospitalization rates, particularly for respiratory infections, but the effect on utilization for children with NI is unknown.MethodThis multicenter retrospective cohort study included hospitalizations of children 1–18 years of age with NI diagnosis codes from 49 children's hospitals. We calculated the percent change in the median weekly hospitalization volumes and the hospitalization resource intensity score (H‐RISK), comparing the early‐COVID era (March 15, 2020 to December 31, 2020) with the pre‐COVID era (same timeframe of 2017–2019). Percent change was calculated over the entire study period as well as within three seasonal time periods (spring, summer, and fall/winter). Differences between infectious and noninfectious admission diagnoses were also examined.ResultsCompared with the pre‐COVID era, there was a 14.4% decrease (interquartile range [IQR]: −33.8, −11.7) in the weekly median number of hospitalizations in the early‐COVID era; the weekly median H‐RISK score was 11.7% greater (IQR: 8.9, 14.9). Hospitalizations decreased for both noninfectious (−11.6%, IQR: −30.0, −8.0) and infectious (−35.5%, IQR: −51.1, −31.3) illnesses in the early‐COVID era. This decrease was the largest in spring 2020 and continued throughout 2020.ConclusionsFor children with NI, there was a substantial and significant decrease in hospitalizations for infectious and noninfectious diagnoses but an increase in illness severity during the early‐COVID era compared with the pre‐COVID era. Our data suggest a need to reconsider current thresholds for hospitalization and identify opportunities to support and guide families through certain illnesses without hospitalization.
Service delivery challenges in HIV care during the first year of the COVID‐19 pandemic: results from a site assessment survey across the global IeDEA consortium
Authors: Brazier Ellen , Ajeh Rogers , Maruri Fernanda , Musick Beverly , Freeman Aimee , Wester C. William , Lee Man‐Po , Shamu Tinei , Crabtree Ramírez Brenda , d'Almeida Marcelline , Wools‐Kaloustian Kara , Kumarasamy N. , Althoff Keri N. , Twizere Christella , Grinsztejn Beatriz , Tanser Frank , Messou Eugène , Byakwaga Helen , Duda Stephany N. , Nash Denis ,   the International epidemiology Databases to Evaluate AIDS
Published: December 2022

AbstractIntroductionInterruptions in treatment pose risks for people with HIV (PWH) and threaten progress in ending the HIV epidemic; however, the COVID‐19 pandemic's impact on HIV service delivery across diverse settings is not broadly documented.MethodsFrom September 2020 to March 2021, the International epidemiology Databases to Evaluate AIDS (IeDEA) research consortium surveyed 238 HIV care sites across seven geographic regions to document constraints in HIV service delivery during the first year of the pandemic and strategies for ensuring care continuity for PWH. Descriptive statistics were stratified by national HIV prevalence (<1%, 1–4.9% and ≥5%) and country income levels.ResultsQuestions about pandemic‐related consequences for HIV care were completed by 225 (95%) sites in 42 countries with low (n= 82), medium (n= 86) and high (n= 57) HIV prevalence, including low‐ (n= 57), lower‐middle (n= 79), upper‐middle (n= 39) and high‐ (n= 50) income countries. Most sites reported being subject to pandemic‐related restrictions on travel, service provision or other operations (75%), and experiencing negative impacts (76%) on clinic operations, including decreased hours/days, reduced provider availability, clinic reconfiguration for COVID‐19 services, record‐keeping interruptions and suspension of partner support. Almost all sites in low‐prevalence and high‐income countries reported increased use of telemedicine (85% and 100%, respectively), compared with less than half of sites in high‐prevalence and lower‐income settings. Few sites in high‐prevalence settings (2%) reported suspending antiretroviral therapy (ART) clinic services, and many reported adopting mitigation strategies to support adherence, including multi‐month dispensing of ART (95%) and designating community ART pick‐up points (44%). While few sites (5%) reported stockouts of first‐line ART regimens, 10–11% reported stockouts of second‐ and third‐line regimens, respectively, primarily in high‐prevalence and lower‐income settings. Interruptions in HIV viral load (VL) testing included suspension of testing (22%), longer turnaround times (41%) and supply/reagent stockouts (22%), but did not differ across settings.ConclusionsWhile many sites in high HIV prevalence settings and lower‐income countries reported introducing or expanding measures to support treatment adherence and continuity of care, the COVID‐19 pandemic resulted in disruptions to VL testing and ART supply chains that may negatively affect the quality of HIV care in these settings.
Cardiovascular risk factors among patients with acute unilateral inner ear hypofunction: A case–control study
Authors: Simões João Filipe Carvalho Pereira Mano , Vlaminck Stephan , Seiça Raquel , Acke Frederic , Miguéis António 
Published: December 2022

AbstractObjectivesTo assess the prevalence of cardiovascular risk factors (CVRFs) and their impact on acute unilateral inner ear hypofunction (AUIEH), including acute unilateral peripheral vestibulopathy (AUPVP), sudden sensorineural hearing loss (SSNHL) and acute unilateral audiovestibular hypofunction (AUAVH).MethodsOne hundred and twenty‐five patients consecutively diagnosed with AUPVP, SSNHL or AUAVH and 250 sex‐ and age‐matched controls were included. Cases presented a mean age of 58.6 ± 14.7 years and included 59 women and 66 men. The correlation between CVRFs (high blood pressure [HBP], diabetes mellitus [DM], dyslipidemia [DLP], cardiocerebrovascular disease [CCVD]) and AUIEH was assessed by multivariate conditional logistic regression analysis.ResultsA higher prevalence of CVRFs was identified in patients than in controls (30 individuals with DM, 53 with HBP, 45 with DLP and 14 with a previous history of CCVD, p < .05). A significantly elevated risk of AUIEH was found in patients with two or more CVRFs (adjusted odds ratio [OR] 5.11; 95% CI 2.23–11.70). Previous CCVD individually predicted AUIEH (OR 8.41; 95% CI 2.36–29.88). Subgroup analysis showed the same tendency for AUPVP and SSNHL.ConclusionAcute unilateral inner ear hypofunction patients presented significantly more CVRFs than controls, and the presence of two or more CVRFs was associated with AUIEH. Future studies evaluating vascular risk in AUIEH may include AUPVP and SSNHL patients from the same source population to better characterize risk profiles that can indicate a vascular origin.Level of Evidence3b
The Genetic Testing Experience of Individuals with Parkinson's Disease
Authors: Richards Sydney , Mu Weiyi , Nusbaum Rachel , Lincoln Katherine , Solimine Julie 
Published: December 2022

ABSTRACTBackgroundThe perspective and experiences of individuals with Parkinson's disease (PD) regarding genetic testing is limited.ObjectivesTo determine if anticipated benefits and negative consequences of genetic testing noted in prior studies have occurred in a surveyed group of patients with PD and to identify reasons why some individuals with PD have not had testing.MethodsIndividuals were surveyed from 22 support/advocacy groups throughout the US. Information about patient demographics and genetic testing were assessed, along with the consequences experienced after testing or anticipated by those who have not had testing. Descriptive statistics, Pearson correlation coefficient, ANOVA, and independent sample t‐test were utilized for data analysis.ResultsOf the genetic testing group (n = 78), most received testing through a research study (44.9%) or a Direct‐to‐Consumer company (46.2%). Most did not meet with a genetic counselor before (87.2%) or after testing (64.1%). Fewer positive and fewer negative consequences were reported after testing compared to the consequences anticipated by those who have not undergone testing (P < 0.001, all comparisons). Of the non‐genetic testing group (n = 166), 49.4% did not undergo testing because they were not aware it was available and 38.0% because their doctor did not offer it.ConclusionsFindings demonstrate the need for providers to have genetic testing discussions with PD patients, who may otherwise seek testing via Direct‐to‐Consumer companies or be unaware it is available. Collaborations with genetic counselors trained in providing anticipatory guidance may assist patients in forming more realistic expectations regarding the consequences experienced after genetic testing for PD.