bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non-coding RNA-EN_181 potentially contributes to the protective effects of N-acetylcysteine against non-alcoholic fatty liver disease in mice
Authors: Yang Wenwen , Guo Rui , Pi Aiwen , Ding Qinchao , Hao Liuyi , Song Qing , Chen Lin , Dou Xiaobing , Na Lixin , Li Songtao 
Published: June 2022

AbstractN-acetylcysteine (NAC) possesses a strong capability to ameliorate high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) in mice, but the underlying mechanism is still unknown. Our study aimed to clarify the involvement of long non-coding RNA (lncRNA) in the beneficial effects of NAC on HFD-induced NAFLD. C57BL/6J mice were fed a normal-fat diet (10 % fat), a HFD (45 % fat) or a HFD plus NAC (2 g/l). After 14-week of intervention, NAC rescued the deleterious alterations induced by HFD, including the changes in body and liver weights, hepatic TAG, plasma alanine aminotransferase, plasma aspartate transaminase and liver histomorphology (haematoxylin and eosin and Oil red O staining). Through whole-transcriptome sequencing, 52 167 (50 758 known and 1409 novel) hepatic lncRNA were detected. Our cross-comparison data revealed the expression of 175 lncRNA was changed by HFD but reversed by NAC. Five of those lncRNA, lncRNA-NONMMUT148902·1 (NO_902·1), lncRNA-XR_001781798·1 (XR_798·1), lncRNA-NONMMUT141720·1 (NO_720·1), lncRNA-XR_869907·1 (XR_907·1), and lncRNA-ENSMUST00000132181 (EN_181), were selected based on an absolute log2 fold change value of greater than 4, P-value < 0·01 and P-adjusted value < 0·01. Further qRT-PCR analysis showed the levels of lncRNA-NO_902·1, lncRNA-XR_798·1, and lncRNA-EN_181 were decreased by HFD but restored by NAC, consistent with the RNA sequencing. Finally, we constructed a ceRNA network containing lncRNA-EN_181, 3 miRNA, and 13 mRNA, which was associated with the NAC-ameliorated NAFLD. Overall, lncRNA-EN_181 might be a potential target in NAC-ameliorated NAFLD. This finding enhanced our understanding of the biological mechanisms underlying the beneficial role of NAC.
Reduced anhedonia following internet-based cognitive-behavioral therapy for depression is mediated by enhanced reward circuit activation
Authors: Hanuka Shir , Olson Elizabeth A. , Admon Roee , Webb Christian A. , Killgore William D. S. , Rauch Scott L. , Rosso Isabelle M. , Pizzagalli Diego A. 
Published: June 2022

AbstractBackgroundMajor depressive disorder (MDD) is a highly prevalent psychiatric condition, yet many patients do not receive adequate treatment. Novel and highly scalable interventions such as internet-based cognitive-behavioral-therapy (iCBT) may help to address this treatment gap. Anhedonia, a hallmark symptom of MDD that refers to diminished interest and ability to experience pleasure, has been associated with reduced reactivity in a neural reward circuit that includes medial prefrontal and striatal brain regions. Whether iCBT can reduce anhedonia severity in MDD patients, and whether these therapeutic effects are accompanied by enhanced reward circuit reactivity has yet to be examined.MethodsFifty-two MDD patients were randomly assigned to either 10-week iCBT (n = 26) or monitored attention control (MAC, n = 26) programs. All patients completed pre- and post-treatment assessments of anhedonia (Snaith–Hamilton Pleasure Scale; SHAPS) and reward circuit reactivity [monetary incentive delay (MID) task during functional magnetic resonance imaging (fMRI)]. Healthy control participants (n = 42) also underwent two fMRI scans while completing the MID task 10 weeks apart.ResultsBoth iCBT and MAC groups exhibited a reduction in anhedonia severity post-treatment. Nevertheless, only the iCBT group exhibited enhanced nucleus accumbens (Nacc) and subgenual anterior cingulate cortex (sgACC) activation and functional connectivity from pre- to post-treatment in response to reward feedback. Enhanced Nacc and sgACC activations were associated with reduced anhedonia severity following iCBT treatment, with enhanced Nacc activation also mediating the reduction in anhedonia severity post-treatment.ConclusionsThese findings suggest that increased reward circuit reactivity may contribute to a reduction in anhedonia severity following iCBT treatment for depression.
The production of space and the changing character of the recording studio
Authors: Goold Lachlan 
Published: June 2022

AbstractThe propagation of low-cost music production technologies changes the way recording artists experience the spatial environments and technology of the recording studio. Concomitantly dwindling recording budgets have led to large-format studio closures. Many artists are choosing do-it-yourself (DIY) recording practices with the help of a producer, or self-produced, in non-purpose-built and domestic environments. This research seeks to understand the differences in creative agency and recording experience for performers in various recording environments. I use a practice-led approach to record performers in DIY recording spaces, large-format recording studios and a hybrid combination of both environments. I then use a Lefebvrian theoretical lens to analyse participant interviews and field notes. This research suggests that artist attitudes towards the choice of recording space are variable, with each participant preferring a different aspect of large-format and domestic spaces depending on which facet of those spaces they are considering. Despite this, the participants seem to experience DIY recording as broadly positive for creativity but respond with views that emphasise freedom from time constraints, a reclamation of power, fewer economic burdens and freedom to experiment. The research indicates that the DIY studio is emerging as a new paradigm in the recording field and defines the current era of music-making.
The Nigerian “End SARS” counter protest and the monumental destruction of cultural heritage
Authors: Adewumi Afolasade A. , Akintayo John Oluwole A. 
Published: June 2022

AbstractThis research responds to the recent destruction of cultural heritage in Nigeria during the protest against police brutality meted out on the populace by a unit of the Nigerian police force known as the Special Anti-Robbery Squad. This article uncovers issues implicated in the destruction of the Iga Idunganran, a national monument. Through a survey questionnaire, the article determines the perceptions of people about African traditional religion and the knowledge of people about the value and significance of heritage loss occasioned by the recent destruction of the palace. Findings reveal that many Nigerians are unaware of the value and significance of the palace as heritage that is essential to societal development. Many Nigerians are suffering from an identity crisis because of colonization. The Nigerian government has not fulfilled its role in protecting cultural heritage. The Nigerian government needs to put structures in place to implement its commitment at the national level.
Comparison of early-stage stenosis and regurgitation results among patients who underwent aortic valve repair
Authors: Tan-Recep Berra Zumrut , Hatemi Ali Can , Yavuz Yasemin , Yildirim Ayse Inci , Ceyran Hakan 
Published: June 2022

AbstractIntroduction:This study aimed to analyse the results of paediatric aortic valve repairs in our institution.Method:The data of 57 patients under 18 years of age who underwent aortic valve repair between 2014 and 2019 were retrospectively analysed. Early postoperative reoperation and hospital mortality rates were evaluated based on the ages of the patients, their preoperative diagnoses, and the surgical techniques used. Survival curves for groups of patients were calculated by Kaplan–Meier analysis.Results:The rate of reoperation was 14% (n = 8), and there were no significant differences regarding valve pathologies and preoperative diagnoses (p > 0.05). Among the repair techniques, tricuspidisation was considered to be a risk factor for reoperation (p < 0.05). Augmentation, the material used (0.1 PTFE or pericardium), and the number of cusps were not found to have significant effects on reoperation or mortality. The mean follow-up period was 29.86 ± 21.30 months. The survival rates of the patients were 88%, 100%, and 88.2% for those with aortic stenosis, aortic insufficiency, and mixed disease, respectively, and no significant difference was found when these rates were evaluated with the log-rank test (p > 0.05). The mortality rate was 8.8% (n = 5), and undergoing surgery before the age of 1 year was found to be significant in terms of mortality (p = 0.032, p < 0.05). The bicuspid aortic valve group had the lowest mortality risk, while the Shone complex group had the highest.Conclusion:With its acceptable reoperation and mortality rates, aortic valve repair should be the first choice of treatment in the paediatric age group. Early results were satisfactory in all groups.
Quantifying the Risk to Health Care Workers of Cough as an Aerosol Generating Event in an Ambulance Setting: A Research Report
Authors: Gedge Dale A. , Chilcott Robert P. , Williams Julia 
Published: June 2022

AbstractIntroduction and Objective:United Kingdom Health Security Agency (UKHSA) guidance related to mask use for health care workers in a non-aerosol generating procedure (AGP) setting has remained as Level 2 water repellent paper mask (surgical mask) only. Energetic respiratory events, such as coughing, can generate vast numbers of droplets and aerosols. Coughing, considered to be a non-AGP event, frequently occurs in the relatively small, confined space of an ambulance (∼25 m3). The report seeks to explore whether existing research can provide an indication of the risk to ambulance staff, via aerosol transmission, of an acute respiratory infection (ARI) during a coughing event within the clinical setting of an ambulance.Methods:International bibliographic databases were searched (CINAHL Plus, SCOPUS, PubMed, and CENTRAL) using appropriate search strings and a combination of relevant medical subject headings with appropriate truncation. Methodological filters were not applied. Papers without an English language abstract were excluded from the review. Grey literature was sought by searching specialist databases OpenGrey and GreyNet, as well as key organizations’ websites. The initial search identified 2,405 articles. Following screening, along with forward and backward citation of key papers identified within the literature search, 36 papers were deemed eligible for the scoping review.Discussion:Attempts to replicate a clinical environment to investigate the risk of transmission of airborne viruses to health care workers during a coughing event provided evidence for the generation of respirable aerosol particles and thus potential transmission of pathogens. In cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), potential to infect versus true airborne transmission is a debate that continues, but there is general consensus that a large variation of cough characteristics and aerosol generation amongst individuals exists. Studies widely endorsed face masks as a source control device, but there were conflicting views about the impact of mask leakage.Conclusion:Further research is required to provide clarity of the risk to health care workers when caring for a coughing patient in the confined clinical ambulance setting and to provide an evidence base to assist in the determination of appropriate respiratory protective equipment (RPE).
Disproportionate Service: Considering the Impacts of George Floyd’s Death and the Coronavirus Pandemic for Women Academics and Faculty of Color
Authors: Simien Evelyn M. , Wallace Sophia Jordán 
Published: June 2022

ABSTRACTThis article focuses on disproportionate service burdens faced by women academics and faculty of color in higher education created by COVID-19 and the massive, multilocation street protests that followed George Floyd’s death. Our work aims to inform provosts, deans, directors, and other institutional actors in academia who recognize the need for documenting structural inequities and investing in high-impact, long-term solutions. Recommendations are offered to meet challenges, given the need to raise colleague awareness of disproportionate service burdens.
IAPT CBT treatment for PTSD following COVID-19-related intensive care admission – a case study
Authors: Skilbeck Lilian , Byrne Suzanne 
Published: June 2022

Abstract
The current case study was conducted as part of the National Health Services and Health Education England implemented IAPT top-up training in trauma-focused cognitive therapy for post-traumatic stress disorder (PTSD). There has been an increase in the number of clients presenting to IAPT with COVID-19 intensive care unit PTSD since the pandemic. However, there are no current unitary guidelines for psychological therapy for this population. Treatment of PTSD using individual trauma-focused cognitive therapy has been shown to be effective for ICU-PTSD. The National Institute for Health and Care Excellence treatment guidelines recommend adapting existing protocols. This study describes how these recommendations were used in the treatment of COVID-19 ICU-PTSD in a 46-year-old male. It illustrates the use of trauma-focused cognitive therapy for PTSD and how ICU trauma memories including hallucinations were conceptualised. It also illustrates how the challenges of co-morbid panic attacks, long COVID and remote working were managed. The client attended 16 individual, 60- to 90-minute video sessions of trauma-focused cognitive therapy, conducted weekly via Microsoft Teams over a period of five months. The treatment plan was conducted in collaboration with the client’s general practitioner, physiotherapists, cardiopulmonary specialists, and his family. Treatment included a timeline, written narrative and imaginal reliving. It also applied stimulus discrimination, behavioural experiments and site visit. At the end of treatment, the client no longer showed clinically important symptoms of PTSD as assessed on the PCL-5 and interview. This was sustained at 3-month follow-up.

Key learning aims.
It is hoped that the reader will increase their understanding of the following:

(1)
Delivery of trauma-focused cognitive therapy for ICU-PTSD.

(2)
Cognitive conceptualisation of the trauma memory including hallucinations.

(3)
Management of co-morbid symptoms.
Exhuming and Preserving Epizonal Orogenic Au‐Sb Deposits in Rapidly Uplifting Orogenic Settings
Authors: Yu Hao‐Cheng , Qiu Kun‐Feng , Deng Jun , Zhu Rui , Mathieu Lucie , Sai Sheng‐Xun , Sha Wu‐Jin 
Published: June 2022

AbstractEpizonal orogenic Au‐Sb deposits are generally Phanerozoic in age, possibly as a consequence of erosion that can entirely remove older mineral deposits in rapidly uplifting orogenic setting. Quantifying post‐mineralization thermotectonic processes is essential for documenting the exhumation and preservation of epizonal deposits, which in turn is critical for constraining regional deformation. This study focuses on the giant Zaozigou deposit, and documents cooling rates using amphibole and biotite Ar‐Ar, zircon U‐Th/He, and apatite fission track dating. Six cooling phases are identified, including Early to Middle Triassic very rapid cooling, Late Triassic rapid cooling, Early Jurassic slow cooling, Middle to Late Jurassic rapid cooling, Cretaceous to Oligocene slow cooling, and Miocene to present rapid cooling. Initial cooling corresponds to thermal exchange between magmatic rocks and wall rocks. Phases two through five are related to a sequence of post‐mineralization compressional, strike‐slip, compressional, and extensional events, pointing to multi‐phase tectonic evolution of the Qinling Orogen since the Late Triassic. Late exhumation is probably related to lateral growth of the Tibetan Plateau and/or to rapid erosion induced by intensification of the Asian monsoon. In total, ∼6.3 km of rock was removed post‐mineralization. We conclude that Cretaceous to Oligocene extension retarded the continuous erosion and thus played an important role in the preservation of Zaozigou. Combined with known orogenic processes, our results demonstrate that a long‐lived extension is a favorable tectonic environment for the preservation of epizonal orogenic Au‐Sb deposits in rapidly uplifting orogenic setting.
Projected Increases in Global Terrestrial Net Primary Productivity Loss Caused by Drought Under Climate Change
Authors: Cao Dan , Zhang Jiahua , Han Jiaqi , Zhang Tian , Yang Shanshan , Wang Jingwen , Prodhan Foyez Ahmed , Yao Fengmei 
Published: June 2022

AbstractUnderstanding present and future impacts of drought on the terrestrial carbon budget is of great significance to the evaluation of terrestrial ecosystem disturbance and terrestrial carbon sink. Here, we evaluate the effect of vegetation net primary productivity (NPP) associated with drought through the difference between the mean NPP in the drought and normal years during a specific time period (30 years). Then, the NPP effects in different vegetation types and climatic zones under baseline stage (1981–2010) and future climate scenarios (RCP2.6, RCP4.5, and RCP8.5) is assessed. The results indicate that the negative NPP extremes are captured in most regions, except for the high‐latitude in the Northern Hemisphere. The NPP loss caused by extreme droughts in 2071–2100 is largest under RCPs, followed by the effects of severe and moderate droughts. Regionally, central United States, southern Africa, central Asia, India, Amazon tropical rainforest, and Australia are projected to experience a significant increase in negative NPP extremes and most of these regions are in arid and semi‐arid and tropical rain forest areas. In contrast, tropical Asia suffers little drought effects. For different vegetation, Evergreen Broadleaf Forest, Closed Shrubland, Open Shrubland, Croplands, and Grassland are the most affected by drought. The largest NPP loss occurs in most part of regions under RCP4.5 scenario, not RCP8.5. Climate change is projected to play the largest role in aggravating the risk of drought‐induced NPP reduction. And meanwhile, the adverse effects of drought on vegetation may be resisted through rational fertilizer utilization and land management in future.
Global Driving of Auroral Precipitation: 1. Balance of Sources
Authors: Mukhopadhyay Agnit , Welling Daniel , Liemohn Michael , Ridley Aaron , Burleigh Meghan , Wu Chen , Zou Shasha , Connor Hyunju , Vandegriff Elizabeth , Dredger Pauline , Tóth Gabor 
Published: June 2022

AbstractThe accurate determination of auroral precipitation in global models has remained a daunting and rather inexplicable obstacle. Understanding the calculation and balance of multiple sources that constitute the aurora, and their eventual conversion into ionospheric electrical conductance, is critical for improved prediction of space weather events. In this study, we present a semi‐physical global modeling approach that characterizes contributions by four types of precipitation—monoenergetic, broadband, electron, and ion diffuse—to ionospheric electrodynamics. The model uses a combination of adiabatic kinetic theory and loss parameters derived from historical energy flux patterns to estimate auroral precipitation from magnetohydrodynamic (MHD) quantities. It then converts them into ionospheric conductance that is used to compute the ionospheric feedback to the magnetosphere. The model has been employed to simulate the 5–7 April 2010 Galaxy15 space weather event. Comparison of auroral fluxes show good agreement with observational data sets like NOAA‐DMSP and OVATION Prime. The study shows a dominant contribution by electron diffuse precipitation, accounting for ∼74% of the auroral energy flux. However, contributions by monoenergetic and broadband sources dominate during times of active upstream solar conditions, providing for up to 61% of the total hemispheric power. The study also finds a greater role played by broadband precipitation in ionospheric electrodynamics which accounts for ∼31% of the Pedersen conductance.
Gravity Waves in Titan's Atmosphere: A Comparison Between Linearized Wave Model Calculations and HASI Observations
Authors: Huang Jianping , Wu Zhaopeng , Cui Jun , Wan Xin , Zhong Jiahao , Hao Yongqiang 
Published: June 2022

AbstractThe Huygens Atmospheric Structure Instrument (HASI) detected wavelike temperature fluctuations from 500 to 1,000 km on Titan. However, these fluctuation structures have not been satisfactorily reproduced by any theoretical model to date. In this study, we construct a full‐wave model to simulate the observed gravity wave structure. The model includes dissipation processes due to molecular viscosity, which increases exponentially with altitude, and eddy viscosity, which dominates the lower atmosphere. Using our model, we reproduced the observed temperature perturbations with the superposition of two gravity wave modes, one with λz = 600 km and λx = 1,600 km while the other with λz = 140 km and λx = 8,000 km. We estimate the thermal effects introduced by gravity waves and find that gravity waves below 900 km may significantly modify temperature structure of the upper atmosphere by tens of Kelvins. The wave‐induced thermal effect is sensitive to the eddy viscosity, which controls the dissipation and thermal conductivity below 900 km. When the eddy viscosity is increased by a factor of five, the thermal effect of gravity waves changes from −89 K cooling to nearly zero. This heating mechanism may contribute to the large temperature variability of 60 K in Titan's upper atmosphere.
Studying the Changes in the Hydro‐Meteorological Components of Water Budget in Lake Urmia
Authors: Vaheddoost Babak , Fathian Farshad , Gul Enes , Safari Mir Jafar Sadegh 
Published: June 2022

AbstractAbrupt changes in the Lake Urmia water level have been addressed in many studies, and yet the link between the water level decline and hydro‐meteorological variables in the basin is a major topic for debate between researchers. In this study, a set of data‐driven techniques is used to investigate the components of the water budget in Lake Urmia. Then, the rate of monthly depth differences (DD), precipitation (P), evaporation (E), potential groundwater head (G), and streamflow (Q) time series between 1974 and 2014 are used in the analysis. Several scenarios and strategies are developed by considering the major changes in the year‐2000, which is believed to be the initiation of the hydrological encroachment in the basin. Simple water budget (WB), dynamic regression (DR), and symbolic regression (SR) techniques are used to simulate the DD with consideration to P, E, G, and Q. Alternatively, the effect of the year 1997 as the potential base‐line for the initiation of significant meteorological trends in the basin is investigated. Conducted analysis showed that the DR models of an autoregressive moving average together with multiple exogenous inputs provide an approximate R2: 0.7 as the best alternative among the selected models. It is shown that the Q and G depict abrupt changes compared to the P and E, while either the year 1997 (climate effect) or the year 2000 (encroachment effect) is considered as the baseline in the study.