bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation analysis of instantaneous impact on the radiant syngas cooler by rapping vibrators
Authors: Cui Hongfei , Yang Weijuan , Shao Lintao , Zhou Zhijun , Zhou Junhu 
Published: November 2022

AbstractSlag or ash removal from water wall tubes in a radiant syngas cooler (RSC) is a routine task in operation, which can effectively increase the overall thermal efficiency. Rapping ash removal is one of the valid methods for shedding off the ash deposits in the high‐pressure surroundings of the RSC. In this study, the model of a real RSC was established by a numerical simulation based on the finite element software ABAQUS, and modal analysis and instantaneous response analysis (IRA) were researched to reveal the natural vibration characteristics of the RSC and aid the design of rapping ash removal. On the basis of the results of natural vibration characteristics and a subsequent harmony response, 16 Hz was set as the impact frequency, balancing off the vibrator number and the water‐tube displacement effect. It was indicated that ash deposit in the area around 1/2 longitudinal position was easy to remove due to great response to rapping action. Moreover, rapping at ½ position generally obtained greater displacement response in the whole RSC. A rapping design was proposed with six vibrators at the ½ longitudinal position and 16 Hz frequency, and then two rapping intervals were investigated comparatively. The case with a half‐cycle interval had a slightly larger response than the one‐cycle case, with a larger displacement in more circumferential tubes as well as with a greater sound pressure response in the RSC.
PROTOCOL: Home‐based care for people with dementia: A systematic review
Authors: Li Yanfei , Li Xiuxia , Li Rui , Chen Nan , Yang Kehu 
Published: November 2022

AbstractThe abstract section should read: This is the protocol for a Campbell systematic review. The objectives are as follows: (1) Which formal HBC services for people with dementia have been tested in an RCT? (2) How effective are the different formal HBC services in improving the physical and mental health outcomes of people with dementia? (3) What is the cost and patient's health service usage of different formal HBC services?
ITULAZAX® versus Alutard SQ® in the treatment of allergic rhinitis induced by pollen from the birch homologous group: A cost‐minimization modeling analysis from the Danish societal perspective
Authors: Rønborg Steen M. , Grand Tobias Sydendal , Brandi Henrik , Pollock Richard F. 
Published: November 2022

AbstractBackground and aimsAllergic rhinitis (AR) is an inflammatory disorder triggered by an allergic immune response to inhaled allergens. Birch pollen is the major allergenic tree pollen in parts of Europe. ITULAZAX® is a sublingual immunotherapy tablet for the treatment of adults with moderate‐to‐severe AR and/or conjunctivitis induced by pollen from the birch homologous group. The aim was to compare the costs of treating AR with ITULAZAX® versus subcutaneous ALUTARD SQ® Betula verrucosa (ALUTARD SQ®) from a Danish societal perspective.MethodsA cost‐minimization model was developed to capture costs of allergy immunotherapy (AIT), interactions with healthcare professionals (HCPs) in three different care settings (general practice, allergy specialist, and hospital), and indirect costs arising from absenteeism and presenteeism. The cost‐minimization analysis was conducted over a 3‐year time horizon with costs reported in 2021 Danish Kroner (DKK) and Euros (EUR) based on the European Central Bank 365‐day average exchange rate. One‐way sensitivity analyses were performed.ResultsThe base case analysis showed that the total cost of treatment over 3 years was estimated to be DKK 49,117 (EUR 6598) per patient with ALUTARD SQ®, compared with DKK 30,996 (EUR 4164) with ITULAZAX®, reflecting a cost saving of DKK 18,121 (EUR 2434) per patient with ITULAZAX® over 3 years. Over the 3‐year time horizon, costs of AIT were predicted to increase by DKK 17,928 (EUR 2408) with ITULAZAX®, while costs of interactions with HCPs were predicted to decrease by DKK 22,528 (EUR 3027) versus ALUTARD SQ®, more than offsetting the increased cost of ITULAZAX®.ConclusionsGiven the equivalent effectiveness of the two AIT products, and the cost savings with ITULAZAX® versus ALUTARD SQ® from a Danish societal perspective, ITULAZAX® should be considered as a cost‐saving alternative to ALUTARD SQ® for the treatment of birch pollen‐induced moderate‐to‐severe AR in adults.
Immobilized Bacterial Cells on Electrospun Nanofibers for Crude Oil Spills Treatment and Bioremediation
Authors: Kegere James , Alblooshi Afra , Nguyen Ha L. , Alnaqbi Mohamed A. 
Published: November 2022

AbstractImmobilization of biological molecules and cells on nanofibers is widely used in many applications ranging from medical to environmental applications. Immobilization materials provide cells with protection and surface for adhesion which in turn increases their efficiency for a particular application and stability over a longer period. Bioremediation of oil spills has recently become popular since scientists have developed processes that rely on cost‐effectiveness and efficacy in crude oil treatments. For improved and sustainable performance of bioremediation, the system requires the development of cost‐effective carrier substrates which undergo slow biodegradability and present a limited negative impact on the environment. Immobilization of bacteria on electrospun polymeric fibers is a recent research development aided by advances in nanotechnology. This could revolutionize bioremediation, treating the problem of crude oil spill pollution. In this review, we discuss the use of electrospinning to manufacture nanofibers entrapping and encapsulating bacterial cells for effective crude oil spill bioremediation. We go further to explain the recent developments in nanofiber technology with special emphasis on the correlation between method of electrospinning and relevant morphology of the formed fibers.
A One‐step Fluorescence Sensor Based on Molybdenum Disulfide Nanosheets for the Detection of Potassium Ions
Authors: He Shiliang , Fan Taojian , Zhang Yingjie , Wei Chenxi , Chen Zhuolang , Shi Yao , Hu Junqing 
Published: November 2022

AbstractDetermination of potassium ion concentration in biological samples is of great significance due to its vital role in the maintenance of physiological activities. Single or few‐layered transition metal dichalcogenides (TMD, e. g., MoS2, WS2, TiS2) have recently found wide applications in optoelectronics and biomedical engineering. Herein, for the first time, MoS2 nanosheets were integrated with G‐quadraplex DNA secondary structures to construct a fluorescence sensor for detecting potassium ions. The biosensor showed merits such as ease of preparation, ease of use, low‐cost, broad linear working range, as well as sufficient sensitivity, specificity and practical applicability, demonstrating its promise as an effective potassium ion sensor for practical applications. To the best of our knowledge, this is the first report on the combination of TMD nanomaterials and DNA quadraplex for the development of nanodevices. The proposed TMD nanosheets‐G‐quadraplex sensing formulation could enable the devise of other nanomachines and nanosensors considering the versatility of TMD nanomaterials and G‐quadraplex‐containing aptamers.
Modifying quantitative sensory testing to investigate behavioral reactivity in a pediatric global developmental delay sample: Relation to peripheral innervation and chronic pain outcomes
Authors: Symons Frank J. , Burkitt Chantel C. , Wilcox George , McAdams Brian , Wendelschafer‐Crabb Gwen , Kennedy William R. 
Published: November 2022

AbstractEarly tactile and nociceptive (pain) mechanisms in children with global developmental delay at risk for intellectual and developmental disability are not well understood. Sixteen children with global developmental delay (mean age = 5.1 years, SD = 1.4; 50% male) completed a modified quantitative sensory testing (mQST) protocol, an epidermal (skin) punch biopsy procedure, and parent‐endorsed measures of pain. Children with reported chronic pain had significantly greater epidermal nerve fiber density (ENFd) compared to children without chronic pain. Based on the mQST trials, ENFd values were associated with increased vocal reactivity overall and specifically during the light touch and cool thermal stimulus trials. The findings support the feasibility of an integrative biobehavioral approach to test nociceptive and tactile peripheral innervation and behavioral reactivity during a standardized sensory test in a high‐risk sample for which there is often sensory dysfunction and adaptive behavior impairments.
A multifaceted field sampling approach for the management of extremely narrow endemic vascular plant species
Authors: Marcenò Corrado , Gristina Alessandro Silvestre , Pasta Salvatore , Garfì Giuseppe , Scuderi Leonardo , Fazan Laurence , Perraudin Viviane , Kozlowski Gregor , Laudicina Vito Armando , Venanzoni Roberto , Guarino Riccardo 
Published: November 2022

AbstractExtremely narrow endemic plant species (ENEs) are generally connected with microrefugia characterized by particular environmental conditions. In‐depth knowledge of the ecological requirements of ENEs is fundamental to plan appropriate conservation measures. Using cross‐cutting technology, this paper gives a multifaceted approach to collect on‐site data on the ecology of ENEs, defines the protocols for a correct sampling design and describes the type of equipment, the time and expenditure needed. Our sampling approach is based on two orthogonal transects, long enough to extrapolate the whole ecological gradient across the area of occupancy of the target species. Microclimatic data are recorded all along the transects through iButton technology, plus a weather station installed at the intersection of the transects. Microtopographic data are recorded with high‐resolution digital elevation model and sub‐metric GPS. Edaphic data are recorded along the transects through standard soil analyses and on‐site evaluation of the seasonal decomposition rate of organic matter. Additionally, vegetation sampling in 4 m2 plots and on‐site germination tests allow to collect data on auto‐ and synecological factors that regulate the life cycle of the target species. Our approach has proved to be cost‐effective and efficient in terms of time spent in the field against the data collected. The most demanding activities were the establishment of the transects and the vegetation sampling. The time spent downloading microclimatic data and testing seed germination was relatively short. Our sampling design allows: (i) to catch as much micro‐topographic variability as possible, both within and out of the tolerance range of the target species, (ii) to minimize the risk of recording identical micro‐topographic conditions compared with a random sampling scheme, and (iii) to ensure quick and relatively easy retrieval of the plots and the equipment both on a multi‐seasonal and multi‐annual basis.
First known observations of brooding, development, and hatching of fertilized eggs for the North Pacific bigeye octopus, Octopus californicus
Authors: Khen Adi , McCormick Lillian R. , Steinke Christine A. , Rouse Greg W. , Zerofski Phil J. 
Published: November 2022

AbstractThe North Pacific bigeye octopus, Octopus californicus (Berry, 1911) is a cold‐water, deep‐sea octopod. Little is known about their biology due to difficulty accessing their natural habitat and obtaining live specimens. Although they are a frequent bycatch product in commercial bottom trawl fisheries, individuals of this species have rarely been raised in captivity and their embryonic development has not yet been documented. Considering these limitations, we were fortunate to have witnessed this process leading to successful hatching in an aquarium setting. Here, we present a brief observational account of the first‐known record of brooding, development, and hatching of fertilized eggs for O. californicus. The incubation time was a maximum of 10 months at a temperature between 8–10°C and embryos hatched over a period of 2.5 months. While more detailed research is needed, this preliminary information contributes to our limited knowledge of this species and supports life history theories of prolonged embryonic development under colder temperatures.
Implications of worsening renal function before hospitalization for acute heart failure
Authors: Wettersten Nicholas , Duff Stephen , Horiuchi Yu , van Veldhuisen Dirk J. , Mueller Christian , Filippatos Gerasimos , Nowak Richard , Hogan Christopher , Kontos Michael C. , Cannon Chad M. , Müeller Gerhard A. , Birkhahn Robert , Taub Pam , Vilke Gary M. , McDonald Kenneth , Mahon Niall , Nuñez Julio , Briguori Carlo , Passino Claudio , Maisel Alan , Murray Patrick T. , Ix Joachim H. 
Published: November 2022

AbstractAimsKidney function changes dynamically during AHF treatment, but risk factors for and consequences of worsening renal function (WRF) at hospital admission are uncertain. We aimed to determine the significance of WRF at admission for acute heart failure (AHF).Methods and resultsWe evaluated a subgroup of 406 patients from The Acute Kidney Injury Neutrophil gelatinase–associated lipocalin Evaluation of Symptomatic heart failure Study (AKINESIS) who had serum creatinine measurements available within 3 months before and at the time of admission. Admission WRF was primarily defined as a 0.3 mg/dL or 50% creatinine increase from preadmission. Alternative definitions evaluated were a ≥0.5 mg/dL creatinine increase, ≥25% glomerular filtration rate decrease, and an overall change in creatinine. Predictors of admission WRF were evaluated. Outcomes evaluated were length of hospitalization, a composite of adverse in‐hospital events, and the composite of death or HF readmission at 30, 90, and 365 days. Biomarkers' prognostic ability for these outcomes were evaluated in patients with admission WRF. One‐hundred six patients (26%) had admission WRF. These patients had features of more severe AHF with lower blood pressure, higher BUN, and lower serum sodium concentrations at admission. Higher BNP (odds ratio [OR] per doubling 1.16–1.28, 95% confidence interval [CI] 1.00–1.55) and lower diastolic blood pressure (OR 0.97–0.98, 95% CI 0.96–0.99) were associated with a higher odds for the three definitions of admission WRF. The primary WRF definition was not associated with a longer hospitalization, but alternative WRF definitions were (1.3 to 1.6 days longer, 95% CI 1.0–2.2). WRF across definitions was not associated with a higher odds of adverse in‐hospital events or a higher risk of death or HF readmission. In the subset of patients with WRF, biomarkers were not prognostic for any outcome.ConclusionsAdmission WRF is common in AHF patients and is associated with an increased length of hospitalization, but not adverse in‐hospital events, death, or HF readmission. Among those with admission WRF, biomarkers did not risk stratify for adverse events.
An energy‐aware resource management method in cloud‐based Internet of Things using a multi‐objective algorithm and crowding distance
Authors: Xu Yanfei , Mohammed Adil Hussein 
Published: November 2022

AbstractInternet of Things (IoT) is predicted to permeate all areas of the physical world, particularly homes and urban settings, in the next years. Cloud‐based IoT is a network of things that can be managed and inspected to create various intelligent systems over the internet. The primary technological difficulty in service computing is swiftly integrating diverse services to serve cross‐organizational business activities. It is one of the famous NP‐hard problems; therefore, this study proposes a novel service composition technique termed multiobjective particle swarm optimization and crowding distance (MOPSO‐CD) approach to solve this problem. The main issue with the MOPSO method is that the search is conducted very quickly, resulting in an incorrect response. To address this issue, we integrate MOPSO with the CD approach to provide an efficient composition service in cloud‐based IoT. The proposed method is simulated using Matlab, and the performance is compared against the performance of three other multi‐objective algorithms. The findings revealed that the proposed method outperforms different algorithms regarding availability, reliability, response time, latency, and energy consumption.
Habituation, part II. Rethinking the habituation paradigm
Authors: Kucharský Šimon , Zaharieva Martina , Raijmakers Maartje , Visser Ingmar 
Published: November 2022

AbstractThe habituation paradigm has been applied to study the development of memory, perception, and other cognitive processes in preverbal infants, making it one of the most prominent experimental paradigms in infant research. However, there are many features of the process of habituation that remain elusive, which results in uncertainty about the best research practices. This article first discusses current practices in habituation research (e.g., the use of habituation criteria) in relation to modelling the process of habituation, revealing several issues that impede progress in the field. To overcome these challenges, we propose to move towards a modelling framework to study critical features of the habituation process. To facilitate this transition, alternative experimental designs are proposed. The article encourages clearer thinking about the process of habituation, such that the theory, design, and analysis are all in line with each other. The article concludes with concrete recommendations to improve current practices in infant habituation research.
Redox‐active ligands as a challenge for electronic structure methods
Authors: Rastetter Ursula , Jacobi von Wangelin Axel , Herrmann Carmen 
Published: November 2022

AbstractTo improve the catalytic activity of 3d transition metal catalysts, redox‐active ligands are a promising tool. These ligands influence the oxidation state of the metal center as well as the ground spin‐state and make the experimental determination of both properties challenging. Therefore, first‐principles calculations, in particular employing density functional theory with a proper choice of exchange‐correlation (xc) functional, are crucial. Common xc functionals were tested on a simple class of metal complexes: homoleptic, octahedral tris(diimine) iron(II) complexes. The spin‐state energy splittings for most of these complexes showed the expected linear dependence on the amount of exact exchange included in the xc functionals. Even though varying redox‐activity affects the electronic structure of the complexes considerably, the sensitivity of the spin‐state energetics to the exact exchange admixture is surprisingly small. For iron(II) complexes with highly redox‐active ligands and for a broad range of ligands in the reduced tris(diimine) iron(I) complexes, self‐consistent field convergence to local minima was observed, which differ from the global minimum in the redox state of the ligand. This may also result in convergence to a molecular structure that corresponds to an energetically higher‐lying local minimum. One criterion to detect such behavior is a change in the sign of the slope for the dependence of the spin‐state energy splittings on the amount of exact exchange. We discuss possible protocols for dealing with such artifacts in cases in which a large number of calculations makes checking by hand unfeasible.
Sustainable process development for the recovery of biobased levulinic acid through reactive extraction
Authors: Kumar Anuj , Shende Diwakar Z. , Wasewar Kailas L. 
Published: November 2022

AbstractBACKGROUNDLevulinic acid is one of the top ten bio‐derived platform chemicals essential for producing many products that are used daily. The recovery of biobased chemicals from industrial streams and fermentation broths is critical due to environmental issues. A few studies have used chemical solvents for the recovery of levulinic acid, but these solvents are toxic for microorganisms. Therefore, green and cheap solvents for the separation of levulinic acid are needed. This study used sunflower oil as a green solvent with trioctylamine and tri‐n‐butyl phosphate for the separation of levulinic acid. The experimental study was presented in the form of important parameters, viz., distribution constant, loading ratio, extraction equilibrium constant, diffusion coefficient, and extraction efficiency. Fourier transform infrared spectroscopy (FTIR) was employed to understand the acid and extractant interactions and 1:1 complex formation was confirmed in organic phase.RESULTSThe experimental results include the distribution coefficients (0.14–0.81 and 0.23–2.15), loading ratios (0.013–0.709 and 0.023–0.53), extraction efficiencies (12.43–44.68% and 19–68.30%), and extraction equilibrium constants (0.47–1.63) with trioctylamine and tri‐n‐butyl phosphate, respectively. Since a single‐stage does not provide sufficient extraction efficiency, multi‐stage extraction was performed. The multistage design shows that trioctylamine and tri‐n‐butyl phosphate must be used in three and five stages, respectively, to get 94.8% and 97% recovery of levulinic acid.CONCLUSIONThis study describes the recovery of levulinic acid from the aqueous phase using trioctylamine and tri‐n‐butyl phosphate with sunflower oil as a sustainable green solvent. The multistage design setup provided approximately 100% recovery of levulinic acid.
Extracellular vesicles derived from the choroid plexus trigger the differentiation of neural stem cells
Authors: Ditte Zuzana , Silbern Ivan , Ditte Peter , Urlaub Henning , Eichele Gregor 
Published: November 2022

AbstractThe choroid plexus secrets cerebrospinal fluid (CSF) composed of electrolytes, cytokines, growth factors, metabolites and extracellular vesicles (EVs) that flow through the interconnected brain ventricles. On their course, CSF components can act as signals that affect, for example, neural stem cells (NSCs) residing in niches of the ventricular wall. We studied EV‐born CSF signals in an in vitro culture system. We purified EVs from the secretome of a choroid plexus cell line (Z310 cells), and from primary choroid plexus cultures and co‐cultured those EVs with NSCs isolated from the niche of the lateral and the third ventricle. EVsZ310 and EVsCHP were purified by differential centrifugation. This yielded fractions of EVs of 50–150‐nm diameter that induced a complex multicellular network formation and NSC differentiation. Both types of EV converted the round NSCs to cells that extended long processes that contacted nearby, alike‐shaped cells. Mass spectrometry showed that the differentiation‐inducing EVZ310 were enriched for membrane and membrane‐associated proteins involved in cell differentiation, membrane trafficking, and membrane organization. We hypothesize that this type of EV Z310 cargo causes changes of stem cell morphology that leads to multicellular networks in the niches. This cell‐shape transition may represent an initial step in NSC differentiation.
Chinese and Indian economic relations and development assistance to Zimbabwe: Rationale, controversies and significance
Authors: Tinarwo Joseph , Babu Suresh Chandra 
Published: November 2022

AbstractRecent economic relations including foreign assistance scenario in Africa show expansion of China and India as emerging bilateral partners, competing with traditional countries in Europe and North America. The results of this paper found that the relationship of China and India with Zimbabwe has resulted in several challenges including increasing resource‐backed debt burden, exploitation of the natural resources, and flouting of constitutional, environmental, and labor provisions. The paper recommends that the Zimbabwean government must demand loans and investments that are contracted under clear terms and conditions, with parliamentary oversight and public scrutiny to avoid abuse by the elites.