bluuebunny/crossref_metadata_2025_split huggingface dataset:
Um retrato fotocartográfico do envelhecimento em Portugal
Authors: Morais Nobre Itamar , Azevêdo Souza Élmano Ricarte 
Published: May 2022

As mais diversas formas de evolução no âmbito da saúde têm trazido melhoriasna qualidade de vida de muitas pessoas ao redor do mundo. A expectativa devida subiu em vários países, segundo a Organização Mundial da Saúde – OMS.Portugal é o quarto país na União Europeia com a maior percentagem de pessoas com maios de 65 anos, isto é, são quase 20% da população. Se a percentagem de idosos é alta, essa parcela da população terá novasnecessidades. Este é o desafio das administrações públicas. Fazer com que as pessoas com uma idade avançada tenham condições de uma vida digna. Este ensaio fotográfico ajuda, a partir da Fotocartografia Sociocultural (Nobre, 2011) a fazer um mapa das condições de vida dos idosos em Portugal. Visitamos as cidades de Lisboa, Coimbra, Nazaré, Fátima, Braga e Porto nos meses de abril e setembro de 2014, entrevistamos os idosos e conhecemos suas perspectivas de vida, suas histórias. Estas cidades estão nas regiões Central e Norte de Portugal, nas quais há uma maior percentagem de pessoas com idade superior a 65 anos. Em uma forma experimental com o uso de telefones móveis (smartphones), foram feitas 30 fotografias, das quais 10 foram selecionadas. É importante dizer que a Fotocartografia Sociocultural é um método de investigação nas Ciências Sociais e que faz a união entre a fotografia e a cartografia, cujas bases são a entrevista em profundidade e a observação participante para construir um mapa visual simbólico dos aspectos socioculturais, neste caso, sobre os idosos. Ou seja, fazendo uma reflexão sobre seus modos de vida. Será que este retrato feito por nós tem um paralelo entre o que dizem os meios de comunicação sobre essa parte da população? Como eles têm vivido atualmente em Portugal? São perguntas que tentamos responder com este ensaio fotográfico.
Pensamento Pós-Colonial e a Problemática da Representação das Vozes Subalternas
Authors: Leite Maria Laís dos Santos 
Published: May 2022

"Pode o subalterno falar?" é considerado um texto relevante não apenas para os estudos pós-coloniais, mas ainda “para os estudos culturais e para a crítica feminista ao indagar as formas de repressão dos sujeitos subalternos, interrogando a própria cumplicidade dos intelectuais contemporâneos nesse processo.” (ALMEIDA, 2010, p. 19). A autora Gayatri Chakravorty Spivak é indiana e nasceu em 1942 em Calcutá, sendo considerada hoje uma das principais referências da epistemologia e das perspectivas feministas e dos estudos pós/decoloniais. A autora acadêmica e literária é uma crítica da interpretação histórica “falogocêntrica” - imperialista e marxista - para ela o feminismo ocidental “burguês” pode ser considerado cumplice do capitalismo internacional na opressão e exploração de mulheres do mundo em desenvolvimento. Para Spivak (2010), a tarefa do intelectual pós-colonial deve ser a de criar espaços por meio dos quais o sujeito subalterno possa falar para que, quando ele ou ela o faça, possa ser ouvido(a). Para ela, não se pode falar pelo subalterno, mas pode-se trabalhar contra a subalternidade, criando espaços no quais o subalterno possa se articular e, com consequência, possa também ser ouvido. Recomendamos a pequena e complexa obra para estudiosos das áreas de gênero e estudos pós/decoloniais de todas as áreas de atuação, especialmente das Ciências Sociais e Ciências Humanas, sejam graduados ou não, e também para não acadêmicos que tenham interesse pelos assuntos nele abordados.
PROJETO SONASTÉRIO
Authors: DINIZ JOAO 
Published: May 2022

Esse artigo apresenta o projeto ‘Sonastério’, estúdio de gravação musical situado na região metropolitana de Belo Horizonte, projetado pelo escritório Joao Diniz Arquitetura Ltda. A obra será descrita e analisada mediante o método ‘Sementes do Espaço: arquiteturas em Processo’ que é também o título da tese de doutoramento pela UFMG, Universidade Federal de Minas Gerais, que avalia essa e outras obras desse escritório de projetos. Esse método de análise foi criado, como um dos objetivos dessa tese, para explicar os procedimentos adotados pelo arquiteto, junto com seus colaboradores, em diversos de projetos, visando uma abordagem ao mesmo tempo teórica e pragmática das questões que promovem a realização de obras arquitetônicas. O método se desenvolve a partir do reconhecimento de seis etapas que ocorrem desde a fase anterior à concepção de determinada obra arquitetônica, até as lições deixadas em sua vivencia. Trata-se então de um método ‘hexa-temporal’ considerando e nomeando sucessivamente as etapas como: circunstância, gênese, desígnio, manufatura, vivência e legado. A aplicação dessas abordagens pode ocorrer em obras construídas respondendo a distintos programas de necessidades, e é possível reconhecer como funciona de forma distinta para cada projeto analisado. No caso do projeto ‘Sonastério’ o texto aborda as especificidades de um projeto que visa a uma adequada inserção na paisagem, buscando a criação de um recolhimento apropriado à criação artística; e, ao mesmo tempo, um exemplar desempenho acústico voltado para à execução e gravação musical, incluindo os espaços de apoio necessários.
TEXTO
Electrochemical Aptasensors for Parkinson’s Disease Biomarkers Detection
Authors: Mikuła Edyta , Katrlík Jaroslav , Rodrigues Ligia R. 
Published: May 2022

Background:
Biomarkers are characteristic molecules that can be measured as indicators of biological process status or condition, exhibiting special relevance in Parkinson’s Disease (PD). This disease is a chronic neurodegenerative disorder very difficult to study given the site of pathology and due to a clinical phenotype that fluctuates over time. Currently there is no definitive diagnostic test, thus clinicians hope that the detection of crucial biomarkers will help to the symptomatic and presymptomatic diagnostics and providing surrogate endpoints to demonstrate the clinical efficacy of new treatments.

Methods:
Electrochemical aptasensors are excellent analytical tools that are used in the detection of PD biomarkers, as they are portable, easy to use, and perform real-time analysis.

Results:
In this review, we discuss the most important clinical biomarkers for PD, highlighting their physiological role and function in the disease. Herein, we review for the first time innovative aptasensors for the detection of current potential PD biomarkers based on electrochemical techniques and discuss future alternatives, including ideal analytical platforms for point-of-care diagnostics.

Conclusion:
These new tools will be critical not only in the discovery of sensitive, specific, and reliable biomarkers of preclinical PD, but also in the development of tests that can assist in the early detection and differential diagnosis of parkinsonian disorders and in monitoring disease progression. Various methods for fixing aptamers onto the sensor surfaces, enabling quantitative and specific PD biomarker detection present in synthetic and clinical samples, will also be discussed.
The Role of microRNAs in Alcoholism: A Meta-analytic Review
Authors: Mohebbati Reza , Sadeghnia Hamid Reza 
Published: May 2022

Introduction:
A growing body of evidence indicates that repeated alcohol exposure or withdrawal
from alcohol can result in persistent molecular and cellular adaptations. One molecular adaptation that occurs is
the regulation of gene expression, which is believed to lead to functional alterations that characterize addiction.
MicroRNAs (miRs) have been recently identified as master regulators of gene expression through posttranscriptional
regulation. The aim of this meta-analytic review was to evaluate the regulatory forms of miRs
during alcoholism.

Methods:
We used several databases such as PubMed, Scopus, and Web of Science without limitations on publication
time. All studies were analyzed by Comprehensive Meta-Analysis software.

Results and Discussion:
Six clinical papers with 243 alcoholic patients and 162 controls were included. In this
study, 1680 articles were initially reviewed and eventually, six clinical studies were included in the metaanalysis.
The results of the meta-analysis showed that according to the random model, the difference between
the upregulation and downregulation of central addiction targets was statistically significant, indicating that
most dopamine- or gamma-aminobutyric acid receptor subunit (GABA)-related miRs are upregulated in alcoholics
(P: 0.00, CI: 0.149-0.439).

Conclusion:
This study strongly suggests that dopamine- or GABA-related miRs were mostly upregulated in
alcoholism. Our findings revealed that about 9% of miRs were downregulated in alcoholism, including miR-
567, miR-126, miR-1, miR-432, and miR-153. To identify other or specific miRs as potential biomarkers in
alcoholics, large-scale studies and more clinical work are required.
Discovery of Active Ingredients in Traditional Chinese Medicine Based on the Analysis
of Odor and Flavor of Compounds
Authors: Wang Dan , Lu Feng , Ai Li , Wu Chun-Jie , Liu Ziqi , Zhang Mengmeng , Zhong Ciping 
Published: May 2022

Background:
The odor and flavor produced by a complex mixture of chemical components with different amounts and thresholds, which is the unique property for food and Traditional Chinese Medicine (TCM). These compounds usually belong to mono- and sesquiterpenes, esters, lipids, and others.

Objective:
This review was aimed to demonstrate the extraction method and reliable technology for identifying the compounds responsible for their odor and flavor.

Method:
Summarize existing techniques for the analysis of taste and odor components and their characteristics, such as electronic nose (enose, EN) and electronic tongue (etongue, ET), which can separate the high-quality food from low quality, natural from artificial food in terms of unique odor and flavor.

Results:
Gas chromatography-olfactometry mass spectrometry (GC-O-MS), a technique coupled Gas chromatography mass spectrometry (GC-MS) with human sense by Olfactory Detector Ports, has been successfully applied for screening the odor-producing components with representative odor for the food or Chinese medicine.

Conclusion:
This current review provides some guidelines for quality evaluation of food or Chinese medicine.
Trabectedin in Cancers: Mechanisms and Clinical Applications
Authors: Wang Jiali , Wang Pengfei , Zeng Zheng , Lin Caiji , Lin Yiru , Cao Danli , Ma Wenqing , Xu Wenwen , Xiang Qian , Luo Lingjie , Wang Wenxue , Shi Yongwei , Gao Zixiang , Zhao Yufan , Liu Huidi , Liu Shu-Lin 
Published: May 2022

Abstract:Trabectedin, a tetrahydroisoquinoline alkaloid, is the first marine antineoplastic agent approved with special anticancer mechanisms involving DNA binding, DNA repair pathways, transcription regulation and regulation of the tumor microenvironment. It has favorable clinical applications, especially for the treatment of patients with advanced soft tissue sarcoma, who failed in anthracyclines and ifosfamide therapy or could not receive these agents. Currently, trabectedin monotherapy regimen and regimens of combined therapy with other agents are both widely used for the treatment of malignancies, including soft tissue sarcomas, ovarian cancer, breast cancer, and non-small-cell lung cancer. In this review, we have summarized the basic information and some updated knowledge on trabectedin, including its molecular structure, metabolism in various cancers, pharmaceutical mechanisms, clinical applications, drug combination, and adverse reactions, along with prospects of its possibly more optimal use in cancer treatment.
A Novel Glycolysis-Related Gene Signature Predicts Prognosis For Cutaneous
Melanoma
Authors: Zhu Lingjun , Zhang Lianghui , Chen Yi , Wang Yiwen , Kong Feifei 
Published: May 2022

Background:
There exists a lack of effective tools predicting prognosis for cutaneous melanoma patients. Glycolysis plays an essential role in the carcinogenesis process.

Objective:
: We intended to construct a new prognosis model for cutaneous melanoma.

Method:
Based on the data from TCGA database, we conducted univariate Cox regression analysis and identified prognostic glycolysis-related genes (GRGs). Meanwhile, GSE15605 dataset was used to identify differentially expressed genes (DEGs). The intersection of prognostic GRGs and DEGs was extracted for the subsequent multivariate Cox regression analysis.

Results:
A prognostic signature containing ten GRGs was built, and the TCGA cohort was classified into high and low risk subgroups based on risk score of each patient. K-M analysis manifested that the overall survival of high-risk group was statistically worse than that of low-risk group. Further study indicated that the risk-score could be used as an independent prognostic factor which effectively predicted the clinical prognosis in patients with different age, gender and stage. GO and KEGG enrichment analysis showed DEGs between high and low risk groups were enriched in immune-related functions and pathways. In addition, a significant difference existed between high and low risk groups in infiltration pattern of immune cell and expression levels of inhibitory immune checkpoint genes.

Conclusion:
A new glycolysis-related gene signature was established for identifying cutaneous melanoma patients with poor prognosis and formulating individualized treatment for them.
WITHDRAWN: Comprehensive Analysis of Cell Death Genes in Colon
Adenocarcinoma based on Multi-omics Data
Authors: Sun Mingjun , Sun Haiying 
Published: May 2022

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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Mitochondrial Targeting Peptide-based Nanodelivery for Cancer Treatment
Authors: Bossmann Stefan H. , Ehsan Sumia , Covarrubias-Zambrano Obdulia 
Published: May 2022

Abstract:
Mitochondria are important intracellular organelles because of their key roles in cellular metabolism,
proliferation, and programmed cell death. The differences in the structure and function of the
mitochondria of healthy and cancerous cells have made mitochondria an interesting target for drug delivery.
Mitochondrial targeting is an emerging field as the targeted delivery of cytotoxic payloads and
antioxidants to the mitochondrial DNA is capable of overcoming multidrug resistance. Mitochondrial
targeting is preferred over nuclear targeting because it can take advantage of the distorted metabolism
in cancer. The negative membrane potential of the inner and outer mitochondrial membranes, as well as
their lipophilicity, are known to be the features that drive the entry of compatible targeting moiety,
along with anticancer drug conjugates, towards mitochondria. The design of such drug nanocarrier conjugates
is challenging because they need not only to target the specific tumor/cancer site but have to
overcome multiple barriers as well, such as the cell membrane and mitochondrial membrane. This review
focuses on the use of peptide-based nanocarriers (organic nanostructures such as liposomes, inorganic,
carbon-based, and polymers) for mitochondrial targeting of the tumor/cancer. Both in
vitro and in vivo key results are reported.
Dexmedetomidine Attenuates Spinal Cord Ischemia-reperfusion
Injury in Rabbits by Decreasing Oxidation and Apoptosis
Authors: Liu Bingbing , Liang Yatong , Huang Weihua , Zhang Hui , Zhou Daiwei , Xiao Xiaoshan 
Published: May 2022

Background:
In brain ischemia, dexmedetomidine (DEX) prevents glutamate
and norepinephrine changes, increases nerve conduction, and prevents apoptosis, but
the mechanisms are poorly understood.

Objective:
This study aimed at examining the protective effect and function of DEX on
spinal cord ischemia-reperfusion injury (SCIRI) and whether the effect is mediated by
oxidative stress and apoptosis (with the involvement of Bcl-2, Bax, mitochondria, and
Caspase-3).

Methods:
Rabbits were randomly divided into the sham group, infusion/reperfusion (I/R)
group, and DEX+I/R group. SCIRI was induced by occluding the aorta just caudal to the
left renal artery for 40 min, followed by reperfusion. DEX was continuously administered
for 60 min before clamping. The animals were evaluated for neuronal functions. Spinal
cord tissues were examined for SOD activity and MDA content. Bcl-2, Bax, and
Caspase-3 expressions were detected by western blotting. TUNEL staining was used for
apoptosis.

Results:
With the extension of reperfusion time, the hind limbs’ neurological function in
the DEX+I/R group gradually improved, but it became worse in the I/R group (all P<0.05
vs. the other time points within the same groups). Compared with I/R, DEX decreased
MDA and increased SOD (P<0.01), upregulated Bcl-2 protein expression (P<0.05),
downregulated Bax expression (P<0.05), decreased caspase-3 expression (P<0.05),
prevented histological changes in neurons, and decreased the apoptotic index of the
TUNEL labeling (P<0.05).

Conclusion:
DEX could attenuate SCIRI in rabbits by improving the oxidative stress
status, regulating the expression of apoptosis-related proteins, and decreasing neuronal
apoptosis.
HERVs Role in the Pathogenesis, Diagnosis or Prognosis of Aging
Diseases: A Systematic Review
Authors: Prieto-Oliveira Paula 
Published: May 2022

Introduction:
HERVs are human endogenous retroviruses, which represent
about 8% of the human genome, and have various physiological functions, especially in
pregnancy, embryo development and placenta formation. However, their involvement in
diseases is not well defined. Some studies have observed changes in HERV expression
according to age.

Objective:
Therefore, the aim of this systematic review was to analyze their role in
pathogenesis and usage as diagnosis or prognosis biomarkers in aging disorders.

Methods:
In this study, a search on the Pubmed interface was performed for papers
published from January 1953 to June 1st, 2021.

Results:
45 articles have been included, which matched the eligibility criteria and
evaluated the following diseases: breast cancer, prostate cancer, amyotrophic lateral
sclerosis (ALS), osteoarthritis, Alzheimer's disease, immuno-senescence, cognitive
impairment, cataract, glaucoma and hypertension.

Conclusion:
In conclusion, the results suggested that HERVs play a role in the
pathogenesis and can be used as biomarkers for the diagnosis or prognosis of aging
disorders.
Prospective Medicines against the Widespread, Emergent, and Multidrugresistant
Opportunistic Fungal Pathogen Candida auris: A Breath of
Hope
Authors: Ramos Lívia de Souza , Silva Laura Nunes , de Mello Thaís Pereira , Frota Heloísa Freire , Branquinha Marta Helena , dos Santos André Luis Souza 
Published: May 2022

Abstract:
The emergence of the pathogen Candida auris is a real concern worldwide, especially
due to its multidrug resistance profile, besides the difficulties in establishing the correct identification
by conventional laboratory methods and its capacity of causing outbreaks in healthcare settings.
The limited arsenal of available antifungal drugs, coupled with the lack of momentum for the development
of new reagents, represent a challenge in the management of such a pathogen. In this
perspective, we have focused on discussing new, promising treatment options for C. auris infections.
These novel drugs include an antifungal agent already approved for medical use in the United
States of America, compounds that are already in clinical trials and those with potential for repurposing
use against this important fungal pathogen.
Noncoding RNA Databases
Authors: Allmer Jens 
Published: May 2022

Abstract:
Diseases such as cancer are often defined by dysregulation of gene expression. Noncoding
RNAs (ncRNA) such as microRNAs are involved in gene expression and cell-cell communication.
Many other ncRNAs exist, such as circular RNAs and small nucleolar RNAs. A wealth of
knowledge is available for many ncRNAs, but the information is federated in many databases. A
small number of highly complementary ncRNA databases are discussed in this work. Their relevance
for cancer research is highlighted, and some of the current problems and limitations are revealed.
A central or shared database enforcing community reporting and quality standards is needed
in the future.
• RNA-seq
• Noncoding RNAs
• Databases
• Data repositories
A Brief Review on Proved Approaches for the Formation of Oxygen Containing
Heterocyclic Compounds through a Tandem Prins Cyclization
Authors: Ranjitha Kapilavayi Venkata Basava , Reddy BogguJagan Mohan , Sree Gonamanda Satya , Rao Ganteda Rama , Jyothi Daruvuri Nirmala 
Published: May 2022

:
Prins reaction is a very useful and important reaction in the field of synthetic organic
chemistry. Prins cyclization is one of the greatest significant synthetic approaches in the total synthesis
of various natural compounds especially pyran and furan units. The addition of aldehydes to olefinic
compounds utilizing acid catalyst has become important for the industry.

:
Aldehydes and alkenes to give different products depending on the reaction conditions, yield an acidcatalyzed
reaction. Formation of Carbon-Carbon bonds is useful to produce 1,3-diol, 1,3-dioxane, β-
halohydrin and allylic alcohols and tetrahydropyrans by using this methodology. Now coming to the
point of tandem Prins cyclization, this method is very useful for the synthesis of fused compounds
and also for the construction of spirocyclic compounds such as tetrahydropyrans or furans. The present
brief review mainly deals with the development of the synthesis of oxygen-containing heterocyclic
compounds by using prins/tandem prins cyclization. This current review is focused mainly on
tandem prins cyclization’s reactions for the particular recent applications and what methods are used
for the construction of the oxygen contained heterocyclic compounds.
A Case Report of Non-puerperal Uterine Inversion
Authors: Arab Maliheh , Talayeh Maryam , Teymoordash Somayyeh Noei , Ghavami Behnaz , Mahmoodi Sheema 
Published: May 2022

Objective:
Non-puerperal uterine inversion is a rare occurrence. The common etiology for this condition is uterine sarcoma, endometrial carcinoma, and myoma.

Case report:
This case is a 44-year old woman with a protruding malodorous vaginal mass, abdominal pain, and urinary retention. Total hysterectomy with bilateral salpingectomy was performed.

Conclusion:
Diagnosis of uterine inversion might be difficult and requires a high index of suspicion.