bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Docking and Study of the Anti-inflammatory Effect of Triterpene
and Diarylheptanoid Isolated from Pellacalyx axillaris
Authors: Mousa Tariq Hussein , Abed Salam Ahmed , Alkhafaji Sura Latif 
Published: November 2022

Objective:
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of drugs widely
used around the world for their analgesic, antipyretic and anti-inflammatory effect, but still have many
limitations due to their side effects. So, these lead to the development of a new approach to search for a
new product from natural plants that have similar therapeutic effects without common side effects like
gastrointestinal ulcers.

Method:
The anti-inflammatory effect of β-amyrin palmitate (1) as triterpene and 1,7-bis (4-
hydroxyphenyl) hept-4-en-3-one (2) as diarylheptanoid, isolated from Pellacalyx axillaris was studied
by molecular docking to find the probability of binding position and binding strength of new compounds with particular Prostaglandin G/H synthase 2 (PDB ID: 1CX2). In vivo acute anti-inflammatory
activity of the isolated compounds (1 and 2) was evaluated in rats using the egg-white induced edema
model of inflammation in a dose correspondent to 3 mg/Kg of Diclofenac Sodium.

Result:
The tested isolated compounds showed a high activity to inhibit the swelling in paw edema
and their anti-inflammatory effect began shortly after the injection of the egg white and continued to
the end of the experiment in comparison to the reference and control.

Conclusion:
The isolated compounds show a long period of activity with a very potent effect, this may
be related to their suitable acidity and may have perfect hydrophilic –lipophilic balance. This is the
first study of anti-inflammatory effect using Paw edema model and molecular docking.
A Comparative Assessment of Regularized Regression Techniques for Modeling the Mechanical Properties of Rubberized Concrete
Authors: Yasin Bilal , Maraqa Faroq , Al-Sahawneh Eid , Al Adwan Jamal , Alzubi Yazan 
Published: November 2022

Background:
Over the last few decades, many researchers have investigated the properties and behavior of concrete mixtures incorporating rubber-based solid wastes as a partial substitution of natural aggregates. Within this context, they have conducted experimental studies and developed numerical models that simulate the nature of rubberized concrete. Some of these mathematical simulations were intended to provide a rapid mixture of proportioning approaches and property estimation methods. Currently, it is believed that regression analysis provides an effective tool to simply construct a mathematical expression that models a set of data. For that reason, multiple linear regression was extensively utilized in predicting rubberized concrete properties in the literature. However, the performances of regularized regression analysis approaches were not evaluated even though they provide better alternatives to traditional regression methods in terms of controlling the overfitting issue.

Objective:
This study aims to assess the performance of Ridge, Lasso, and elastic net regression models in estimating the compressive and tensile strengths, and modulus of elasticity of rubberized concrete. Additionally, it intends to benchmark their capabilities against the traditional multiple linear regression method.

Methods:
Multiple linear regression, Ridge regression, Lasso regression, ElasticNet regression, Bayesian ridge regression, Stochastic gradient descent, Huber regression, and Quantile regression methods were used in the study.

Result:
In general, the research findings illustrated the superior performance of regression assessment in modeling the mechanical properties of rubberized concrete.

Conclusion:
Indeed rubberized concrete mechanical properties can be better modeled using regularized regression techniques, such as ElasticNet-based SGD compared to traditional methods, such as MLR.
Low-dose empagliflozin as adjunct to hybrid closed-loop insulin therapy in sub-optimally controlled adults with type 1 diabetes: a randomized crossover controlled trial
Authors: Melissa-Rosina Pasqua, , Adnan Jafar, , Alessandra Kobayati, , A. Tsoukas, Michael , Ahmad Haidar, 
Published: November 2022

<p> </p>
<p><strong>Objective: </strong>To assess whether low doses of empagliflozin as adjunct to hybrid closed-loop therapy improve glycemia compared to placebo in adults with type 1 diabetes who are not able to achieve targets with the system alone. </p>
<p><strong>Research Design and Methods: </strong>A double-blind, crossover, randomized controlled trial was performed in sub-optimally controlled (HbA1c 7.0-10.5%) adults who were not able to achieve a target time-in-range (3.9-10.0 mmol/L) ≥ 70% after 14 days of hybrid closed-loop therapy. Three 14-day interventions were performed with placebo, empagliflozin 2.5 mg, or empagliflozin 5 mg, as adjunct to the McGill Artificial Pancreas. Participants were assigned in a 1:1:1:1:1:1 ratio with blocked randomization. The primary outcome was time-in-range (3.9-10.0 mmol/L). Analysis was by intention to treat and a p-value of less than 0.05 was regarded as significant. This trial is registered, NCT04450563.</p>
<p><strong>Results: </strong>24 participants completed the study (50% male, age 33 ± 14 yrs, HbA1c 8.1 ± 0.5%). The time-in-range was 59.0 ± 9.0% for placebo, 71.6 ± 9.7% for empagliflozin 2.5 mg, and 70.2 ± 8.0% for empagliflozin 5 mg (p <0.0001 between empagliflozin 2.5 mg and placebo, and empagliflozin 5 mg and placebo). Mean daily capillary ketone levels were not different between arms. There were no serious adverse events, diabetic ketoacidosis, or severe hypoglycemia in any intervention.</p>
<p><strong>Conclusions: </strong>Empagliflozin 2.5 mg and 5 mg increased time-in-range on hybrid closed-loop therapy by 11–13 percentage points compared to placebo, in those who otherwise were unable to attain glycemic targets. Future studies are required to assess long-term efficacy and safety.</p>
Pemberdayaan Masyarakat Melalui Budidaya Porang (Amorphophallus muelleri) di Desa Hanura Kabupaten Pesawaran Lampung
Authors: Winarno Gunardi Djoko , Effendi Irwan , Fathul Farida , Wibowo Lestari 
Published: November 2022

Pemberdayaan bagi masyarakat pedesaan sangat penting dilakukan untuk membangkitkan motivasi, meningkatkan ilmu pengetahuan, ketrampilan, membuka peluang kerja dan kesejahteraan. Salah satu kegiatannya melalui budidaya porang yang selama ini sedang dikembangkan di Desa Hanura, Propinsi Lampung. Metode yang digunakan dengan FGD dan penyebaran kuisioner. Responden sebanyak 15 orang yang merupakan kelompok tani Sistem Hutan Kerakyatan Lestari. Mereka pada umumnya telah mengenal tanaman porang tetepi tidak mengetahui manfaat porang. Semua responden termotivasi akan menanam porang karena yakin usaha tanaman ini menguntungkan. Kendala yang dihadapi berupa kurangnya permodalan dan pengetahuan budidaya yang masih sedikit sehingga perlu adanya kerjasama dengan pemerintah daerah, Bumdes, dan perguruan tinggi.
Effects of Micro-Credit Scheme on Rice Production among Smallholder Farmers in Kwali Area Council, Abuja
Authors: Obagbemi Sunday Dare , Bamidele Joseph , Bako Hauwa , Alabuja Funso O. , Ajayi Anuoluwapo H. , Sennuga Samson Olayemi 
Published: November 2022

This study examined the effects of microcredit schemes on rice production among smallholder farmers in Kwali area council Abuja, FCT. A survey research design was employed in the study. A total of 100 respondents were used in the study and they were sampled using a multi-stage sampling technique. Primary data was used for the study, and these were collected using well–structured questionnaires Regression analysis based on Cobb-Douglas model was conducted to check how micro-credit influences productivity. Based on the findings, it was discovered that 60% of the respondents were male, 52% were married with an average household size of 5 persons. Results further revealed that 70% of the respondents had 5-15 years of farming experience, and 45% of the respondents had secondary education. The main source of credit accessed by the smallholder farmers is the cooperative society. The study revealed as follows; educational level, household size, farming experience and access to credit were the significant variables that increased rice production among smallholder farmers. This study recommends that commercial banks should ensure that agricultural loan is giving priority, especially to smallholder farmers, as this will enhance the increase in quantity and quality of rice production.
THE MOTIVATION OF LEARNING IN STUDENTS
Authors:   AUREL VLAICU UNIVERSITY OF ARAD, ALINA FELICIA ROMAN 
Published: November 2022

The motivation for learning illustrates the determination each student has towards this important process. When the motivation starts from within each student, we say that it is an intrinsic motivation, and when it comes from the outside we will call it an extrinsic motivation.	The motivation for learning is the dynamic and directional energetic process of the entire learning process. Motivation is the key to our entire behavior, and therefore to our learning behaviour. It is also important to note that the motivation for learning is vital for the efficiency of learning.	In our research we aim to investigate some elements related to students` motivation for learning. The method of investigation of the problem of students` motivation in learning is the survey, conducted using the questionnaire as a tool. The sample of subjects consists of two hundred and twenty-two students from the “1 December 1918” University of Alba Iulia, year I, II and III, from different specializations. Among the indicators presented in the questionnaire we can include: aspects that lead to the increase of motivation for learning, which is the main reason for which they learn, how much time they spend daily on learning, whether they carry out a specific program when they learn; what solutions they resort to when they encounter a learning problem, etc. The conclusions are drawn up based on the statistical analysis and confirm the presence of original elements about the motivation of students’ learning.
KEPATUHAN WAJIB PAJAK: PENERAPAN PERATURAN PEMERINTAH NOMOR 23 TAHUN 2018 (STUDI PADA CV SPORT CENTRE)
Authors: Aminah Siti , Bulutoding Lince , Sari Nur Rahmah 
Published: November 2022

Abstrak, Tujuan dari penelitian ini adalah untuk menganalisis penerapan kebijakan pajak penghasilan final dengan tarif 0,5% melalui Penetapan Peraturan Pemerintah Nomor 23 Tahun 2018 bagi wajib pajak pelaku Usaha Mikro, Kecil dan Menengah (UMKM) dalam meningkatkan penerimaan pajak dari sektor UMKM. Peraturan Pemerintah Nomor 23 Tahun 2018 merupakan pengganti dari peraturan pemerintah nomor 46 tahun 2013 dengan tarif 1% turun menjadi 0,5%. Selain meringankan dengan tarif pajak rendah, peraturan tersebut juga memberi kemudahan perhitungan pajak bagi wajib pajak.Metode penelitian yang digunakan adalah metode penelitian kualitatif. lokasi penelitian di lakukan pada CV Sport Center. Penelitian ini menjadikan paradigma interpretif sebagai paradigma penelitian dengan fenomenologi sebagai pendekatan penelitian. Langkah-langkah dalam analisis data kualitatif melalui empat proses, yaitu pengumpulan data, menyortir data yang tidak diperlukan, menyajikan dan menganalisis data, dan menyimpulkan data. Hasil dari penelitian ini adalah semua responden memahami tentang penerapan peraturan pemerintah nomor 23 tahun 2018 serta patuh terhadap pembayaran pajaknya berdasarkan peraturan tersebut.
ONIOM2-DFT study of N2, O2 and NO interaction with Ce-MOR: Active sites and thermodynamics
Authors: Izquierdo Rodolfo , Pérez Ana , Cubillán Néstor 
Published: November 2022

A theoretical study was carried out for the adsorption of N2, O2, NO and NO+ with Cerium (Ce) modified mordenite (MOR). A two-layer ONIOM2 (two layer Integrated molecular Orbital + molecular Mechanics) methodology was employed, combining UFF (Universal Force Field) and DFT (Density Functional Theory) calculations for the low and high level, respectively. The formation of active Ce species based on the adsorption of CeO+ on the crystallographic positions T1, T2 and T4 in the H-MOR was studied. The geometrical, vibrational and thermodynamic results indicate that the Ce atom of CeO+ binds exothermically and spontaneously to two of the non-equivalent (Om) crystallographic oxygens of MOR (TnOm1Om2) according to: T1O1O4, T1O2O3, T2O4O7, T2O5O7 and T4O7O10 (T: Al or Si). The results of the interaction of N2, O2, NO and NO+ with Ce-MOR indicate that only exothermic and spontaneous adsorptions occur on the active sites located over the main channel of the 12-membered ring (12-MR) according to T1O1O4, T2O5O7 and T4O7O10. In general, the Ce-MOR system stabilizes electrophilic [CeO(NO+)] species, with possible activity deNOx reactions in the presence of nucleophilic reductants such as NH3; while for CeO(NO) species adsorbed on MOR a dynamic equilibrium between κ1NO, κ1ON, κ2NO adsorptions is reported which could be applicable for deNOx catalysis in the absence of reductants. On the basis of thermodynamic reaction functions, it is proposed that the most likely site for the location of active CeO+ is T2O5O7.
Analysis of antimicrobial resistance and genetic correlations of Escherichia coli in dairy cow mastitis
Authors: Li Ke , Hou Mingyuan , Zhang Lin , Tian Mengyue , Yang Ming , Jia Li , Liang Yanyan , Zou Dongmin , Liu Ruonan , Ma Yuzhong 
Published: November 2022

Abstract

Introduction

Escherichia coli is a widespread environmental pathogen frequently causing dairy cow mastitis. This bacterium is particularly capable of acquiring antimicrobial resistance, which can have severe impacts on animal food safety and human health. The objective of the study was to investigate antimicrobial resistance and genetic correlations of E. coli from dairy cow mastitis cases in northern China.

Material and Methods
Forty strains of E. coli from 196 mastitis milk samples were collected, susceptibility to 13 common antibiotics and the prevalence of resistance genes were tested in these strains, and the genetic characteristics were identified by multilocus sequence typing.

Results
The results showed that most isolates were multidrug resistant (MDR) (75%), and the resistance rates to cefazolin, trimethoprim-sulfamethoxazole and ampicillin were 77.5%, 55.0%, and 52.5%, respectively. The representative genes of the isolates were aadA (62.5%) and tet(B) (60.0%). Multilocus sequence typing showed 19 different sequence types (STs) and 5 clonal complexes (CCs) in the 40 isolates, mainly represented by ST10 and CC10. The strains of the same ST or CC showed a high level of genetic relatedness, but the characteristics of their antimicrobial resistance were markedly different.

Conclusion
Most E. coli isolates in the study were MDR strains. Some strains of the same ST or CC showed diverse resistance characteristics to common antimicrobials. Therefore, E. coli from dairy cow mastitis in northern China should be investigated to elucidate its antimicrobial resistance and genotypes.
PENGEMBANGAN INDUSTRI KERUPUK KAMANG “PITARUAH MANDEH” MELALUI PERBAIKAN KEMASAN
Authors: Ariyetti Ariyetti , Wijayanti Ruri , Anggia Malse , Arziyah Dewi , Yusmita Lisa , Mutiar Sri 
Published: November 2022

Usaha Kerupuk Kamang yang terletak di Tapi, Jorong Pakan Sinayan, Nagari Persiapan Kamang Tangah, Kecamatan Kamang Magek, Kabupaten Agam merupakan produsen kerupuk kamang. Permasalahan yang dihadapi mitra adalah keterbatasan dalam pengolahan dan packaging kemasan. Tujuan dari pengabdian masyarakat ini adalah memberikan pelatihan kepada mitra sehingga permasalahan yang dihadapi dapat teratasi. Pelatihan yang dilakukan meliputi pengolahan dan packaging. Dalam pelaksanaannya, metoda yang digunakan yaitu pelatihan dalam pengolahan yang baik dan bersih serta pelatihan dan bantuan alat packaging berupa sealler, kemasan dan label kemasan. Luaran dari kegiatan ini adalah mitra dapat menghasilkan produk yang konsisten setiap kali produksi dan packaging yang menarik sehingga menarik daya minat pembeli. Hal ini juga dapat meningkatkan kualitas produk dan juga meningkatkan pendapatan mitra.
Kata kunci : Pengolahan, pelatihan, packaging, kualitas, mitra
ABSTRACT
The business Kerupuk kamang located in Tapi, Jorong Pakan Sinayan, Nagari Persiapan Kamang Tangah, Kecamatan Kamang Magek, Kabupaten agam is a producer of Kerupuk Kamang. The problems faced by partners are limitations in processing and packaging.The purpose of this community service is to provide training to partners so that the problems they face can be resolved. The training carried out includes processing and packaging. In its implementation, the method used is training in good and clean processing as well as training and assistance in packaging tools in the form of sealers, packaging and packaging labels. The output of this activity is that partners can produce consistent products every time they are produced and attractive packaging that attracts buyers interest. It can also improve product quality and alsi increase partner income.
Keywords : Processing, training, packaging, quality, partner
KOMUNIKASI INFORMASI DAN EDUKASI SARAPAN SEHAT DALAM MENINGKATKAN PENGETAHUAN SISWA SEKOLAH DASAR
Authors: Fitriani Fitriani , Farisni Teungku Nih , Yarmaliza Yarmaliza , Reynaldi Fitrah , Zakiyuddin Zakiyuddin , Syahputri Veni Nella 
Published: November 2022

Sarapan pagi mampu memenuhi zat gizi anak sekolah 15-30 %, sehingga akan berpengaruh besar terhadap konsentrasi anak belajar. Berbagai penelitian menunjukkan kebiasaan sarapan anak sekolah di Indoensia tergolong buruk termasuk mutu dan nilai gizi masih di bawah Angka Kecukupan Gizi (AKG). Metode yang digunakan dalam pengabdian masyarakat ini dilakukan dengan tiga tahap,tahap pertama dengan melakukan pretest pada kelompok sasaran, tahap kedua dilanjutkan dengan memberikan Komunikasi Informasi Edukasi (KIE) pada anak-anak tentang pentingnya sarapan pagi dan jenis – jenis sarapan yang tepat sebelum kesekolah. Tahapan ketiga dilanjutkan posttest tentang sarapan pagi. Hasil penilaian dari kegiatan pengabdian menunjukkan tingkat peningkatan pengetahuan peserta meningkat sebesar 91,1, % atau 31 orang. Dapat disimpulkan bahwa setelah mendapatkan KIE adanya peningkatan pengetahuan siswa Sekolah Dasar tentang sarapan pagi.
Kata kunci : Komunikasi, informasi, edukasi, sarapan, sehat
ABSTRACT
Breakfast is able to meet the nutrients of school children 15-30%, so it will have a big effect on the concentration of children studying. Various studies have shown that the breakfast habits of school children in Indonesia are classified as poor, including the quality and nutritional value which is still below the Nutritional Adequacy Ratio (RDA). The method used in this community service is carried out in three stages, the first stage is by conducting a pretest on the target group, the second stage is continued by providing Educational Information Communication (KIE) to children about the importance of breakfast and the right types of breakfast before going to school. The third stage was followed by a posttest about breakfast. The results of the assessment of service activities showed the level of increase in the knowledge of participants increased by 91.1% or 31 people. It can be concluded that after getting KIE there is an increase in the knowledge of elementary school students about breakfast.
Keywords: Communication, information, education, breakfast, healthy
المساواة في الميراث بين الرؤية التفسيرية والنِّسوية الإسلاميّة التأويلية(دراسةٌ نقديةٌ)
Authors: SHAKIR KHAWLAH MAHDI , RAIHAN NOOR NAJEH 
Published: November 2022

نالت مسألة مساواة الرجل مع المرأة أهمية بالغة في الفكر النسوي الحداثي المعاصر، حيث تعتبر قضية المرأة المسلمة وحقوقها من أهم القضايا التي شهدت صراعاً فكرياً بين (الإسلام والغرب)، ولذلك عمدّت صاحبات القراءة الحداثية النِّسوية إلى تناول قضية المرأة تناولاً يستطعن من خلاله ايجاد توافق بين التشريعات الإسلاميّة وآليات التحديث الفكري الغربي، حيث قدمت النسويات لمعالجة هذه المسألة من خلال النصّ القرآني نفسه متجاوزات بذلك التفسير التقليدي (الذكوري)، معتقدات تمام الاعتقاد بأن الحالة المأساوية للمرأة المسلمة كانت بسبب تأويلات المفسرين (الخاطئة) للآيات القرآنية الخاصة بالمرأة، لذا رأت النسويات أنه لا بدّ من إعادة النظر في تفسير تلك الآيات وتجديد قراءاتها، قراءة تتسق مع التطور المادي، مبنية على سياقات منهجية تتخذ من مفهوم الجندر والمساواة الإنسانية أساساً عملياً، وقد حاولنا في هذا البحث تقديم أنموذج عن القراءات الحداثية النِّسوية للنص القرآني حول موضوع (إرث المرأة)، وتقديم رؤية تحليلية نقدية عن هذا الخطاب الحداثي المعاصر.
Quality of life, out-of-pocket expenditures, and indirect costs among patients with the central nervous system tumors in Thailand
Authors: Tunthanathip Thara , Sae-heng Sakchai , Oearsakul Thakul , Kaewborisutsakul Anukoon , Inkate Srirat , Madteng Suphavadee , Tanvejsilp Pimwara 
Published: November 2022

Objectives:
The aim of this study was to investigate out-of-pocket (OOP) expenditures, indirect costs, and health-related quality of life (HRQoL) associated with the central nervous system (CNS) tumors in Thailand.

Materials and Methods:
A prospective study of CNS tumor patients who underwent first tumor resection at a tertiary care institution in Thailand was conducted. Patients were interviewed during hospitalization for undergoing first surgery. Within 6 months, they were interviewed once more if the disease continued to progress. Costs collected from a patient perspective and converted to 2019 US dollars. For dealing with these skewed data, a generalized linear model was used to investigate the effects of disease severity (malignancy, progressive disease, Karnofsky performance status score, and histology) and other factors on costs (OOP, informal care, productivity loss, and total costs). P < 0.05 was considered statistical significant for all analysis.

Results:
Among a total of 123 intracranial CNS tumor patients, there were 83 and 40 patients classified into benign and malignant, respectively. In the first brain surgery, there was no statistical difference in HRQoL between patients with benign and malignant tumors (P = 0.072). However, patients with progressive disease had lower HRQoL mean scores at pre-operative and progressive disease periods were 0.711 (95% confidence interval [CI]: 0.662–0.760) and 0.261 (95% CI: 0.144–0.378), respectively. Indirect expenditures were the primary cost driver, accounting for 73.81% of annual total costs. The total annual costs accounted for 59.81% of the reported patient’s income in malignant tumor patients. The progressive disease was the only factor that was significantly increases in all sorts of costs, including the OOP (P = 0.001), the indirect costs (P = 0.013), and the total annual costs (P = 0.001).

Conclusion:
Although there was no statistical difference in HRQoL and costs between patients with benign and malignant tumor, the total costs accounted for more than half of the reported income in malignant tumor patients. The primary cause of significant increases in all costs categories was disease progression.