bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nano-formulations: Recent Trends for Ocular Bioavailability Enhancement
Authors: Chaudhary Roobal , Mishra Ravinesh 
Published: April 2022

Eye is a critical part of the body that is readily available and with damage having direct effects on the life of an individual. Delivery of ocular drugs always remain challenging for healthcare professionals and scientists all over the world due to the challenges that dynamic opthalamic environment provides. These challenges involves different barriers like corneal epithelium, corneal stroma, sclera and other bio-membranes (static barriers), choroidal or conjunctival blood flow, lymphatic clearance, tear turnover (dynamic barriers) and efflux pumps/enzymes(metabolic barriers).Ocular diseases include various diseases affecting different parts of the eye. The eye presents comprehensive perspectives and difficulties in the distribution of medicaments, primarily due to the exceptional ability inherent in this mechanism for drugs to enter the main circulatory system and also for eye barrier limitations. Even if conventional non-invasive and invasive treatments like eye drops, injectable preparations and implantable devices are available but these treatments either have bioavailability issues or serious adverse eye effects. Additionally, the new concept of nanoscience and nano-technology gives new a pathway for treating ocular disease. Different active molecules were engineered to communicate with nano-carriers to pass these eye barriers and interact closely with unique specific eye tissues. This study highlights the latest advances in nano-formulations for ophthalmic diagnosis and provides discussions in the mainstream of opthalamic diseases about the role of nano-formulations in nearby future.
Keywords: ocular diseases, nano-technology, static barrier, dynamic barrier, nano-carriers, bioavailability.
To King or Not to King: A Canonical-Historical Approach to Ruth
Authors: MOORE MICHAEL S. 
Published: April 2022

Abstract
Contemporary approaches to Ruth tend to focus on the book's internal structure and contents. Only rarely is sufficient attention given to the book's external context, particularly its canonical-historical context. In Judges 17–21 all of the major characters balk in the face of challenge. Priests, landowners, husbands, wives, and warriors all abandon their responsibilities. In Ruth, however, the main characters valiantly shoulder their responsibilities, however burdensome. In Judges, men treat women insensitively, shamefully, even violently. In Ruth, women are treated like partners on a common mission. Why? Having been led by the book of Judges (particularly the self-contained anthology incorporating chaps. 17–21) to wonder whether the one-and-only source of Israel's agony is kinglessness, Ruth is a canonical-historical surprise. Both Ruth 1–4 and Judges 17–21 come from the premonarchical period of the "judges," yet each offers a radically different response to this fluid situation. To read Ruth against its canonical-historical context not only reconnects us with some of the book's earliest interpreters, it also generates newer literary and sociological insights into the theological message of this beloved short story.
Structure and Interpretation in Hebrews 8:1–10:18: A Symphony in Three Movements
Authors: COCKERILL GARETH LEE 
Published: April 2022

Abstract
Most scholars agree that Heb 8:1–10:18 is the author's exposition of the effective sacrifice of the Son/high priest. There is, however, no consensus about how this section should be subdivided into smaller sections. In this study I argue that Heb 8:1–10:18 is best understood as a "symphony" in three movements (8:1–13; 9:1–22; 9:23–10:18) on the themes of "sanctuary" (8:1–2; 9:1–10; 9:23–24), "sacrifice" (8:3–6; 9:11–15; 9:25–10:14), and "covenant" (8:7–13; 9:16–22; 10:15–18). The themes of "sanctuary" and "covenant" support the central theme of "sacrifice." The first movement (8:1–13), by alluding to Ps 110:1 and citing Jer 31:31–34, establishes the bare fact that Christ's sacrifice must be different from human sacrifices because it pertains to the heavenly sanctuary and establishes the new covenant. The second movement (9:1–22) describes the sacrifices used in the Tabernacle ritual and in the establishing of the old covenant by allusion to the Pentateuch. The purpose of this description is to show that these sacrifices were inadequate but pointed toward the adequate self-sacrifice of Christ and the cleansing power of His blood. The third movement (9:23–10:18) focuses on the quality of Christ's sacrifice by expounding Ps 110:1; Ps 40:6–8; and Jer 31:31–34. The high point of this symphony is reached in Heb 10:5–10, the heart of this third movement. These verses affirm that Christ's effective sacrifice is the willing offering of himself unto death as an obedient human being.
Zmiany zawartości cukrów w bulwach ziemniaka pod wpływem herbicydu i biostymulatorów
Authors: Zarzecka Krystyna , Gugała Marek , Domański Łukasz 
Published: April 2022

Materiał badawczy stanowiły bulwy ziemniaka zebrane z trzyletniego doświadczenia polowego założonego w trzech powtórzeniach metodą split-plot. Pierwszy czynnik stanowiły dwie odmiany jadalne ‘Malaga’ i ‘Oberon’. Drugim czynnikiem było pięć sposobów aplikacji herbicydu i biostymulatorów: 1. obiekt kontrolny – bez herbicydu i biostymulatorów; 2. herbicyd Avatar 293 ZC; 3. herbicyd Avatar 293 ZC i biostymulator PlonoStart; 4. herbicyd Avatar 293 ZC i biostymulator Aminoplant; 5. herbicyd Avatar 293 ZC i biostymulator Agro-Sorb Folium. W świeżej masie bulw oznaczono zawartość cukrów ogółem, cukrów redukujących i sacharozy metodą Schoorla-Luffa. Odmiana ‘Oberon’ zawierała istotnie mniej cukrów ogółem, cukrów redukujących i sacharozy niż ‘Malaga’. Chemiczna regulacja zachwaszczenia nie miała wpływu na zawartość cukrów ogółem, miała tylko aplikacja wymienionych biopreparatów.
QHY-174M-GPS Camera as the Device for Photometry of Artificial Satellites
Authors: Kudak Viktor , Perig Vasyl 
Published: April 2022

Abstract
In this paper, we make an attempt to use the QHY174M-GPS camera for the photometry research of fast-rotating artificial objects including debris, satellites and rocket bodies. This device is useful for imaging occultations, eclipses, meteors, and so on due to a highly precise recording of the time (GPS-based) and location of the observation on every frame and fast readout of the CMOS detector. The precision of time registration by the QHY174M-GPS camera is at the level of microseconds. All light curves obtained by studied camera during observations of artificial satellites in this work were carried out at Derenivka Observatory of Uzhhorod National University, Ukraine. The created photometric system with QHY174M-GPS camera as the detector and reflector telescope with parameters D=120mm, F=114mm, FOV=2.82° × 1.76° was calibrated. For target observations, SharpCap software was used. For the purposes of photometry processing, ccd_phot software was developed using Python 3.8 programming language with astropy and photutils packages. Photometry observations of artificial satellites of the Earth and standard stars were carried out. Over 80 lightcurves of artificial satellites were obtained. Comparing synchronous observations from two sites, separated 15 km from each other, we can conclude that photometry on the QHY174M-GPS camera gave us the same shape of lightcurve and additional advantages, such as time of exposure or simplicity of usage.
Bayesian Inference for SIR Epidemic Model with dependent parameters
Authors: Qaffou Abdelaziz , Maroufy Hamid El , Zbair Mokhtar 
Published: April 2022

Abstract
This paper is concerned with the Bayesian inference for the dependent parameters of stochastic SIR epidemic model in a closed population. The estimation framework involves the introduction of m − 1 latent data between every pair of observations. Kibble’s bivariate gamma distribution is considered as a good candidate prior density of parameters, they give an appropriate frame to model the dependence between the parameters. A Markov chain Monte Carlo methods are then used to sample the posterior distribution of the model parameters. Simulated datasets are used to illustrate the proposed methodology.
Dynamic Motions of the Cabin Mounted on the Mono-Hull Planing Boat Using Suspension System in Waves
Authors: Bahrami Hassan , Ghassemi Hassan 
Published: April 2022

Abstract
The necessity for higher speed and appropriate seakeeping performance of boats has led to extensive research. Hence, this research mainly discusses the optimal behavior of the boat against motions. From an economic point of view, reducing motions of the boat minimizes the damage caused by shock and vibration to the boat and equipment. Other benefits include comfort and safety and, as a result, improved human operating ability. Suspension systems are rarely used as motion controller in a boat. In multi-hull boats, the hull is an inseparable part of the vessels, so the wave will affect crew and equipment. This paper proposes and evaluates a novel concept boat equipped with a suspended cabin. The hull and superstructure (cabin) are separated in this new form by a simple passive suspension system. This study used numerical analysis to examine the seakeeping performance of the planing boat Fridsma model equipped with a passive suspension system under regular wave conditions. The hydrodynamics of the planing hull were modeled using commercial software, STAR-CCM+. For simulation of the passive suspension system between boat and cabin, MATLAB software was used. Results showed that the motion of the cabin, which is where the crew and equipment are located, decreased in regular waves.
Automated Motion Heatmap Generation for Bridge Navigation Watch Monitoring System
Authors: Gokcek Veysel , Kocak Gazi , Genc Yakup 
Published: April 2022

AbstractMost ship collisions and grounding accidents are due to errors made by watchkeeping personnel (WP) on the bridge. International Maritime Organization (IMO) adopts the resolution on the Bridge Navigation Watch Alarm System (BNWAS) detecting operator disability to avert these accidents. The defined system in the resolution is very basic and vulnerable to abuse. There is a need for a more advanced system of monitoring the behaviour of WP to mitigate watchkeeping errors. In this research, a Bridge Navigation Watch Monitoring System (BNWMS) is suggested to achieve this task. Architecture is proposed to train a model for BNWMS. The literature reveals that vision-based sensors can produce relevant input data required for model training. 2D body poses belonging to the same person are estimated from multiple camera views by using a deep learning-based pose estimation algorithm. Estimated 2D poses are projected into 3D space with a maximum 8 mm error by utilising multiple view computer vision techniques. Finally, the obtained 3D poses are plotted on a bird’s-eye view bridge plan to calculate a heatmap of body motions capturing temporal, as well as spatial, information. The results show that motion heatmaps present significant information about the behaviour of WP within a defined time interval. This automated motion heatmap generation is a novel approach that provides input data for the suggested BNWMS.
On the Use of Selected 4th Generation Nuclear Reactors in Marine Power Plants
Authors: Drosińska-Komor Marta , Głuch Jerzy , Breńkacz Łukasz , Ziółkowski Paweł 
Published: April 2022

Abstract
This article provides a review of the possibility of using different types of reactors to power ships. The analyses were carried out for three different large vessels: a container ship, a liquid gas carrier and a bulk carrier. A novelty of this work is the analysis of the proposal to adapt marine power plants to ecological requirements in shipping by replacing the conventional propulsion system based on internal combustion engines with nuclear propulsion. The subjects of comparison are primarily the dimensions of the most important devices of the nuclear power plant and the preliminary fitness analysis. It was assumed for this purpose that the nuclear power plant fits in the engine room compartment and uses the space left after the removal of the combustion engines. At the same time, this propulsion provides at all times sufficient energy for port, technological and shipping operations at an economically justifiable speed. For deep-sea vessels, which are supposed to reach null emissions of CO, CO2, NOx, SOx and H2O, this is one of the most reasonable solutions. Finally the paper proves that all the above-mentioned marine functions could be effectively applied in power plants equipped with 4th generation nuclear reactors.
Replica-Exchange Enveloping Distribution Sampling: Calculation of Relative Free Energies in GROMOS
Authors: Rieder Salomé R. , Ries Benjamin , Champion Candide , Barros Emilia P. , Hünenberger Philippe H. , Riniker Sereina 
Published: April 2022

Molecular dynamics (MD) simulations have become an important tool to investigate biological systems. Free-energy calculations based on MD are playing an increasingly important role for computer-aided drug design and material discovery in recent years. Free-energy differences between pairs of end-states can be estimated using well-established methods such as thermodynamic integration (TI) or Bennett’s acceptance ratio (BAR). An attractive alternative is the recently developed replica-exchange enveloping distribution sampling (RE-EDS) method, which enables estimating relative free-energy differences between multiple molecules from a single simulation. Here, we provide an introduction to the principles underlying RE-EDS and give an overview of the RE-EDS pipeline. In addition, we provide a description of the two complementary tools RestraintMaker and amber2gromos. We briefly discuss the findings of three recent applications of RE-EDS to calculate relative binding or hydration free energies. In all three studies, good agreement was found between the results obtained using RE-EDS and experimental values as well as values obtained using other free-energy methods.
Influence of drying methods on the quality of grain fiber of alcohol production
Authors: Ovtov Vladimir Alexandrovich , Tsurenko Pavel Denisovich , Gorshkov Kirill Andreevich , Tretyakov Nikita Evgenievich 
Published: April 2022

The article provides a substantiation of the kinematic parameters of the drive of the shaft of the planting apparatus of the onion planter, which ensures the supply of onion with the bottom down at a speed range from 3.6 to 6.48 km / h, and also presents the design of a continuously variable gearbox and describes its work.
Influence of sowing time on the yield of spring wheat in Northern Kazakhstan
Authors: Tulayev Yuriy Valerievich , Somova Svetlana Vladimirovna , Abuova Altynay Burkhatovna , Tulkubayeva Saniya Abiltaevna 
Published: April 2022

The research was carried out in order to determine the most optimal terms of sowing spring wheat when cultivating on a stubble precursor in the conditions of southern chernozems of the Kostanay region. The terms of sowing of spring wheat of the «Omskaya 18» variety were studied: May 15 (control), May 18, May 22, May 25, May 27, May 30 and June 05 in the fields of the 4-field grain-steam (steam – wheat – wheat – wheat) crop rotation.Soil cultivation technology- No-till.Records and observations were carried out according to the standard generally accepted methodology. An agrochemical survey at the experimental site showed that before sowing, the soil supply with nitrate nitrogen was characterized as low, mobile phosphorus – average, and exchange potassium – very high. On average, for the 2018-2020 years of research, the reserves of productive moisture in the soil during the sowing of spring wheat were characterized as good. It was found that the low on average 1.47t/ha, yield of spring wheat at the early sowing date of May 15, 2020, was primarily due to the lack of productive precipitation and high temperatures, which fell on a critical phase of development for the crop, affecting the grain filling. For the period of 2018-2020 years yield apparently were increased. As a matter of fact results get up to +0,43 t/ha for per hectare from 25th may and get up to 1,90-1,99 tons for per hectare in average. It was revealed that the sowing dates are reflected on the quality. So, an early date decreases the full-scale grain weight, meanwhile sowing, from 22th May till the 5th June formed the grains of the second class.
Penerapan Malcolm Baldrige Terhadap Penanganan Covid-19 Puskesmas Kota Dumai Provinsi Riau
Authors: Dainingsih Eka Wahyu , Enimay Enimay , Hartono Budi 
Published: April 2022

Penanganan COVID-19 dipuskesmas termasuk pelayanan Kesehatan yang kepada public sehingga diperlukan pelayanan yang bermutu dari segala aspek. Penelitian ini bertujuan untuk menganalisis penanganan COVID-19 dan menentukan level puskesmas dengan motode Malcolm Baldrige di Puskemas Kota Dumai. Penelitian ini di lakukan pada bulan Agustus – Oktober 2021dengan menggunakan desain Cross Sectional. Populasi Penelitian ini adalah Tim COVID-19 di puskesmas. Jumlah sampel 129 dengan teknik Purposive Sampling. Penelitian ini menggunakan desain Kuantitatif analitik dimana di lakukan uji analisi univariat dan bivariat dengan nilai P = < 0,05. Variable independen adalah Kepemimpinan, Perencanaan Strategis, Fokus Pasien, Pengukuran, Analisis dan manajemen, Fokus pada tim, Fokus pada proses, dan Hasil Kinerja. Sedangkan Variabel dependent adalah pelaksanaan penanganan COVID-19 di Puskesmas. Pengumpulan data di lakukan melalui kuesioner yang dibagikan kepada responden. Mayoritas kategori kurang baik yaitu kepemimpinan 51,9%, perencanaan strategis 59,7%, fokus pada pasien 58,9%, pengukuran, analisis dan manajemen 70,9%, fokus pada tim 74,4%, fokus pada proses 75,2% dan hasil kinerja 51,9%. Observasi mayoritas penanganan Covid-19 kategori kurang baik 66,7%. Mayoritas terdapat hubungan antara Malcolm Baldrige dengan Penanganan COVID-19 (P = < 0,050). Hanya Fokus pada Proses yang tidak berhubungan (P = > 0,943) dengan penanganan COVID-19. Puskesmas kota Dumai perlu menganalisis Penanganan COVID-19 dengan motode Malcolm baldrige, sehingga puskesmas dapat memberikan pelayanan yang bermutu bagi publik.
Efektivitas Penggunaan Media Video Tutorial dalam Peningkatan Pengetahuan Mahasiswa pada Pembelajaran Praktikum Manajemen Rekam Medis
Authors: Sugiarto Puput , Suharyo Suharyo 
Published: April 2022

Pandemi Covid-19 mulai menjangkit masyarakat Indonesia sejak bulan Maret 2020 hingga kini. Selama masa pandemi Covid-19, diberlakukan pembatasan kegiatan sosial berskala besar untuk mencegah semakin bertambahnya penularan Covid-19. Salah satu yang terdampak adalah sektor pendidikan tinggi vokasional dimana pendidikan diselenggarakan dengan metode pembelajaran dalam jaringan. Diperlukan pengembangan dalam implementasi pembelajaran praktikum melalui inovasi media pembelajaran menggunakan video tutorial yang bertujuan agar kompetensi mahasiswa tetap tercapai. Tujuan penelitian ini adalah untuk mengetahui perbedaan pengetahuan mahasiswa tentang manajemen rekam medis sebelum dan sesudah diberikan media video tutorial. Desain penelitian yang digunakan adalah pra eksperimen dengan rancangan one group pretest-postest. Sampel yang diambil dalam penelitian ini sebanyak 97 mahasiswa melalui teknik total sampling. Hasil penelitian dianalisis menggunakan uji wilcoxon dan diperoleh hasil bahwa ada perbedaan signifikan terhadap pengetahuan mahasiswa tentang manajemen rekam medis sebelum dan sesudah diberikan media video tutorial dalam pembelajaran praktikum. Dengan diterapkannya video tutorial dalam pembelajaran praktikum ini, mampu mewujudkan pembelajaran praktikum yang efektif bagi mahasiswa.
PEMBERDAYAAN MASYARAKAT DI DESA BALOY KECAMATAN BLANG MANGAT DALAM APLIKASI PUPUK HAYATI UNTUK BUDIDAYA TANAMAN HORTIKULTURA
Authors: Nazimah Nazimah , Nilahayati Nilahayati , Safrizal Safrizal , Fachrurrazi Sayed 
Published: April 2022

Indonesia sebagai negara agraris masih mengandalkan sektor pertanian sebagai sektor yang berperan penting dalam menunjang perekonomian nasional. Dari sektor pertanian, sektor hortikultura merupakan komoditas yang sangat prospektif, dan kebutuhan pasar domestik akan hasil tanaman holtikultura sangat tinggi. Tanaman hortikultura memiliki nilai ekonomis yang tinggi maka banyak sekali orang yang berprofesi sebagai petani menanamnya, misalnya seperti sayuran dan buah-buahan. Jadi secara umum holtikultura adalah segala kegiatan bercocok tanam seperti sayur-sayuan, buah-buahan, ataupun tanaman hias dimana lahan (kebun atau pekarangan rumah) sebagai tempatnya. Pupuk hayati berperan dalam mempengaruhi ketersediaan unsur hara makro dan mikro, efisiensi hara, kinerja sistem enzim, meningkatkan metabolisme, pertumbuhan dan hasil tanaman.. Kegiatan ini dilakukan di desa baloy kecamatan blang mangat kota Lhokseumawe dengan metode observasi, penyuluhan, pendampingan dan demonstrasi pembuatan pupuk hayati. Upaya pemberdayaan masyarakat yang berbasis desa binaan dalam pemanfaatan lahan kosong menjadi lahan produktif dengan budidaya tanaman hortikultura khususnya tanaman sayur – sayuran melalui aplikasi pupuk hayati sangat efektif dilakukan karena dapat meningkatkan pengetahuan dan pemahaman masyarakat dalam pengelolaan lahan kosong, pemanfaatan kotoran hewan,teknik budidaya tanaman secara efektif terutama pada lahan perkaranagan sebagai upaya untuk meghasilkan sayuran organic yang berkualitas dan sehat sehingga manpu meningkatkan kesejahteraan masyarakat baik dari segi kesehatan, maupun dari sudut ekonomi. Kelebihan lain dari aplikasi pupuk hayati adalah dapat menghasilkan sayuran organik yang bebas dari bahan kimia sehingga tidak menimbulkan pencemaran lingkungan. Sayuran organik juga lebih aman dikonsumsi dan harga produksi dari pertanian organik lebih mahal dibanding dengan non organic.
Analisis Kesulitan Siswa dalam Pembelajaran Matematika Materi Teorema Pythagoras Ditinjau dari Minat Belajar Siswa di SMP Negeri 1 Rantau Utara
Authors: Ritonga Eka Dewi Sari , Hasibuan Lily Rohanita 
Published: April 2022

Penelitian ini bertujuan untuk mendeskripsikan kesulitan siswa dalam pembelajaran teorema phytagoras ditinjau dari minat belajar siswa. Jenis penelitian ini menggunakan deskriftip kualitatif dengan subjek penelitian adalah 3 orang siswa dari 34 siswa kelas VIII SMP Negeri 1 Rantau Utara setiap siswa mewakili dari masing-masing kategori minat belajar yakni rendah, sedang tinggi. Hasil penelitian adalah siswa dengan kategori minat belajar rendah mengalami kesulitan dalam memahami konsep, terlihat dalam jawaban siswa hanya menjumlahkan mengurangkan yang diketahui dalam soal nomor 1 dan 2 kategori minat rendah juga mengalami kesulitan melakukan operasi bilangan, menyelesaikan soal verbal, membedakan simbol. Siswa kategori sedang mengalami kesulitan dalam melakukan operasi bilangan di mana hasil akhir yang diberikan siswa tidak sesuai dengan informasi pada soal nomor 1, 2. Adapun siswa dengan minat belajar tinggi mengalami kesulitan memberikan simbol nama satuan pada saol nomor 1, 2.