bluuebunny/crossref_metadata_2025_split huggingface dataset:
OR2. A significant ten-year risk of fatal cardiovascular disease estimation to predict D-Dimer level in hospitalised COVID-19 patients
Authors: Cristo Yosua , Napitupulu Bertha G , Simanjuntak Mutiara 
Published: April 2022

Abstract

Aims
After the COVID-19 pandemic, the risk of thrombosis and bleeding has been an important issue. It is reported that higher D-dimer levels are associated with poor prognosis. Cardiovascular disease risk has also been reported to poor prognosis of COVID-19. Both cardiovascular disease risk and high D-dimer level can be a lethal combination leading to death in COVID-19 patients. We are aiming this research to analyse the capability ten-year risk of fatal cardiovascular disease obtained from SCORE-Risk chart to predict the D-dimer level in hospitalised COVID-19 patients.

Methods and Results
This is a cross-sectional study including 85 moderate-severe hospitalised COVID-19 patients without previous cardiovascular disease. We assessed the patient’s cardiovascular risk by using SCORE-Risk chart and separate samples into two D-dimer groups. Comparison between patient’s clinical variables and D-Dimer level is done by using Mann-Whitney analysis. Variables which show p value &lt;0.2 will then be analysed by Logistic Regression.
There are 27 patients (31.8%) with a high cardiovascular risk. Median D-dimer is 560 ng/mL. Mann-Whitney analysis comparing patient’s clinical variables with D-dimer shows CRP, blood glucose, lactic acid and SCORE-Risk chart give p-value with value &lt; 0.2. The logistic regression analysis shows that SCORE-Risk chart is the strongest predictor of higher D-dimer level with OR 5.647 (1.670-19.092; p value 0.005) with 88.2% specificity and 45.1% sensitivity.

Conclusions
Ten-year risk of fatal cardiovascular disease measured by SCORE-risk chart can be used as accurate predictor of higher D-dimer level on moderate-severe COVID-19 patients.
OR10. Association between heart functional capacity with depression severity on patient with coronary artery disease
Authors: Pintaningrum Y , Humaera N N , Rafiq A , Tanti A 
Published: April 2022

Abstract

Aims
Coronary artery disease has become the main factor of heart failure. Current research has shown association between heart failure with depression. However even before the heart failure, patient with coronary artery diseases may have depression. This study aims to investigate the correlation between heart functional capacity based on new york heart association scale with presence and severity of depression in patient with coronary artery disease.

Methods and Results
50 Patients diagnosed with coronary artery diseases who agree to participate completes patient health questionnaire-9. Patient’s coronary artery disease severity determined by patient functional heart based on capacity new york heart association. Chi square test used to find correlation.

Discussion
Based on chi-square methods (sig new york heart association: 0.014, patient health questionnaire: 0.021) p &lt; 0.05, there is a strong correlation between functional heart capacity based on new york heart association assessment with presence and severity of depression in patient with coronary artery diseases. It shows the correlation not only found in heart failure patient and the depression confirmed in coronary artery disease patients at Nusa Tenggara Province Hospital using patient health questionnaire-9.
OR13. Cardiac Arrythmias on COVID19 Patients: Characteristics, Correlated Risk Factors and Associated Outcomes
Authors: Najiyah H H , Prakoso P P , Wardhani D , Rahmawati M , Wibowo R H , Tiksnadi B B 
Published: April 2022

Abstract

Background
Arrythmias in COVID19 patients were often found. This study was aimed to investigate characteristic, risk factors, and outcome of arrhythmic COVID19 patients.

Methods
This was a single-centered study. All confirmed COVID19 patients admitted from May 2020 until March 2021 were included. Data were obtained from medical records. Patients with no ECG or incomplete medical record were excluded. Bivariate analysis through Chi Square was used to define association between arrhythmia risk factors, and outcomes.

Results
374 patients were included, ranged from 2 until 85 years old (mean 52.5 ± 15, median 54). Mostly were males (53.7%) with 10 days median hospice care. Fifty eight patients (15.50%) had arrhythmia, which were mainly sinus tachycardia, supraventricular tachycardia, ventricular extra systole (3.7% each) and atrial fibrillation (3.5%). Congestive heart failure (CHF) (31.9%) and hypertension (28.7%) were the main comorbid. Bivariate analysis was conducted. CHF increased risk of arrhythmia by two times (RR: 2.15, CI 95%: 1.21 – 3.83, p &lt; 0.008) and chloroquine use by 1.17 times (RR: 1.17, CI 95%: 1.05 – 1.11, p &lt; 0.04). Arrhythmia events increased mortality risk by 2.5 times (RR: 2.52, CI 95%: 1.41–4.48, p &lt; 0.001). Eighteen patients (31.03%) with arrhythmia died, especially those with atrial fibrillation (7 patients).

Conclusion
Sinus tachycardia, supraventricular tachycardia, ventricular extra systole, and atrial fibrillation were the most arrhythmia found. CHF and the use of chloroquine increased risk of arrhythmia. Arrythmia itself, especially atrial fibrillation, should be monitored as it increased mortality.
OR14. Cardiac Index by Right Heart Catheterization was an Independent Predictor of Mortality in Adult Pulmonary Arterial Hypertension-associated with Congenital Heart Disease with Shunt
Authors: Rochmat M B , Dinarti L K , Setianto B Y , Hartopo A B , Anggrahini D W , Satwiko M G 
Published: April 2022

Abstract

Background and Aims
Pulmonary arterial hypertension (PAH) is a common complication of congenital heart disease (CHD). There were several variables predictor of mortality in PAH-CHD from previous studies, but study predictor of mortality in PAH-CHD with shunts has never been done, especially in Indonesia. This study aims to identify independent predictors of mortality among adult PAH-CHD with shunt in Dr. Sardjito Hospital, Yogyakarta, Indonesia.

Method and Results
We conducted a retrospective cohort study that included adult PAH-CHD patients with shunts from COHARD-PH (The Congenital HeARt Disease in adult and Pulmonary Hypertension) registry who were recruited from July 2012 - October 2020. Twelve variables were selected as potential predictors of mortality. Predictor variables were obtained from clinical (WHO-functional class, SaO2, 6-min walking distance), laboratory (haemoglobin, NT-pro BNP), echocardiographic (pericardial effusion, defect size, TAPSE), and hemodynamic (RA pressure, cardiac index, SvO2, flow ratio) data at the time of diagnosis of PAH. Baseline characteristics showed significantly lower systolic blood pressure, higher incidence of Eisenmenger syndrome, higher NT-pro BNP, and lower cardiac output in subjects who died as compared to those survived. Multivariate analysis showed cardiac index as an independent predictor of mortality (OR 7.69; p = 0.011). Systolic blood pressure was a significant confounder of cardiac index in affecting mortality (OR 10.56; p = 0.001).

Conclusion
Cardiac index was an independent predictor of mortality of PAH-CHD with shunts. Systolic blood pressure was a significant confounder of cardiac index on mortality.
OR28. Diagnostic delay in Congenital Heart Disease Related Pulmonary Arterial Hypertension: Insights from the Single Tertiary Hospital Center of Patients With Pulmonary Hypertension Registry In East Java Indonesia
Authors: Fadlan Muhamad Rizki , Aziz Indra Jabar , Martini Heny 
Published: April 2022

Abstract

Aims
The aim of this study was to determine the time from the onset of symptoms to the diagnosis of PAH associated with CHD in Saiful Anwar general Hospital,Malang and to determine the factors with delayed definitive diagnosis.

Methods
The Registry enrolled 128 adult patients with CHD-PAH from January 2019 to December 2020. Patients were considered to have delayed disease recognition if . 2 years elapsed between symptom onset and the patient receiving a CHD-PAH diagnosis, starting on PAH-specific therapy, or receiving a diagnosis by right-sided heart catheterization.

Results
In 54.6% of patients, symptoms were experienced &gt; 2 years before CHD-PAH was recognized. The mean diagnostic interval from symptom onset to diagnostic RHC was 3.18 ± 1.75 years, while Overall, 9.3%, 25% and 65.7% of patients were diagnosed after &lt;1, 1–2 and &gt; 2 years, respectively). There was significant proportion of delayed diagnosed &gt; 2 years in Secundum ASD compare than ≤ 2 years (74.3% vs 51.7%. Respectively, ,p=0.014, OR 2.6 95%CI : 1.2-5.6). Patients who life in remote area (OR 1.82; 95%CI 1.48-2.26), and General practitioner as Physician consulted at symptom onset (OR 1.72;95%CI 1.64-2.46) were independent predictors of longer diagnostic interval. We found significant different level of MPAP and PVR in patients who was delayed time to diagnosed CHD related to PAH &gt; 2 years compare than ≤ 2 years (55.32±8.8 vs 42.4±10.2, 10.6±1.28 vs 4.2±1.42 respectively ,P=0.014, P = 0.012).

Conclusions
We show’s that ASD secundum as subtype of CHD, Patients who life in remote area, and General practitioner as Physician consulted at symptom onset were independent predictors of longer diagnostic interval.
OR37. Factors associated with in-hospital mortality in patients hospitalized with acute coronary syndrome
Authors: Ardining H , Niazta N A , Karimullah D H 
Published: April 2022

Abstract

Background and Aims
Acute coronary syndrome (ACS) remains a source of high mortality worldwide, therefore it is important to determine factors associated with worse outcomes to better develop strategies to reduce the burden of disease. This paper aims to describe the characteristics of patients admitted with ACS to Kediri General Hospital and factors associated with in-hospital mortality.

Methods and Result
In this study, 117 patients admitted with ACS to Kediri General Hospital between January and June 2020 were included. Data were collected retrospectively from medical records and analysed using SPSS software v25. The median age was 60 (36-93) years old, 64 (54,7%) were male. They were presented either with STE-ACS (41%) or NSTE-ACS (59%). During hospitalization, 18 (15,4%) died. The bivariate analysis showed the patients who died were predominantly female (22,6% vs 9,4%, p = 0.048); had higher prevalence of Killip IV (38,9%, p = 0,003); higher prevalence of clinical signs of heart failure (23,7% vs 6,9%, p = 0,012); lower admission systolic blood pressure (117 ± 26,0 vs 137 ± 37,0, p = 0,036); lower admission diastolic blood pressure (70,6 ± 20,6 vs 81,5 ± 20,5, p = 0,04); and higher heart rate (104 ± 24 vs 91 ± 22, p = 0,026). From multivariable analysis, variables significantly associated with in-hospital mortality were decreased consciousness (OR 11, 95% CI 1.327-92.4, p = 0.026) and Killip class IV (OR 9.558, 95% CI 2.016-45.317).

Conclusion
Decreased consciousness and Killip class IV were significant independent predictors of in-hospital mortality in ACS.
OR45. Improving the migratory function of endothelial progenitor cells under high glucose conditions via engineering with human umbilical cord blood mesenchymal stem cell-derived secretome
Authors: Susanti M , Oktaviono Y H , Lefi A 
Published: April 2022

Abstract

Aims
Human umbilical cord blood mesenchymal stem cells (hUCB-MSC) secreted a group of paracrine factors known as secretome. It has the ability to promote neovascularization and angiogenesis, and it is thought to be capable of modulating EPC function. The capability of hUCB-MSCs-derived secretome in enhancing EPC migration under high glucose condition, which is expected to mimic the metabolic disturbance that occurs in patients with type 2 diabetes mellitus, has been not yet established. This study aims to elucidate the effect of Human Umbilical Cord Blood Mesenchymal Stem Cell (hUCB-MSCs)-derived secretome on the EPCs migration under high glucose conditions.

Method and Results
EPCs were isolated from peripheral blood samples of chronic coronary syndrome patient and cultured for three days. Cultured EPCs were incubated with high glucose for five days and were treated with secretome at various concentration. The migration of EPCs was assessed using the Transwell migration assay. hUCB-MSC-derived secretome induced the migration capability of EPC with at least 20% concentration of secretome, this effect was more potent under high glucose conditions with the least concentration of secretome was 10% (p &lt; 0.001). The migratory function of EPCs was intact on short term exposure of high glucose.

Conclusion
Our finding suggest that hUCB-MSCs-derived secretome may enhance migratory function of EPCs under high glucose conditions. hUCB-MSCs-derived secretome may serve as a promising cell-free regenerative therapy.
OR50. The Prevalence of Cardiovascular Comorbidity in the Severe COVID-19 Patients and Its Correlation to Malignant Ventricular Arrhythmia, Neutrophile-Lymphocyte Ratio (NLR) and D-Dimer
Authors: Siagian A P B , Napitupulu B G 
Published: April 2022

Abstract

Aims
This study aims to describe the prevalence of cardiovascular comorbidities and its correlation to ventricular arrhythmia, NLR and D-Dimer levels in the severe COVID-19 patients.

Methods
This study was a retrospective analytical study. The data of severe COVID-19 patients from Murni Teguh and Susanna Wesley Hospital Medan from January to May 2021 were collected. Data of cardiovascular comorbidities, cause of death, NLR, and D-dimer levels were collected. The categorical data were analysed using Chi-Square, while the numerical data were analysed using an independent T-test or Mann-Whitney test.

Results
Ninety samples were collected. The causes of death were unshockable cardiac arrest (64.8%), ventricular arrythmia (12.2%), and septic shock (22.2%). There were 43 (47.3%) patients with cardiovascular comorbidites. Coronary arterial disease (27.5%) was the most prevalent. Any cardiovascular comorbidites (P = 0.016, OR = 5.956, CI = 1.208 – 29.370) and CAD (P = 0.044, OR = 3.789, CI = 1.309 – 13.823) were significantly related to ventricular arrythmia. The NLR-Ratio was higher in atrial fibrillation patients (42.21 ± 45.84, P = 0.031). The D-dimer level was higher in patients with any CV comorbidities (5488.47 ± 6252.22 ng/mL, P = 0.021), heart failure (5564.70 ± 9495.52 ng/mL, P = 0.033) and in hypertensive heart disease (5873.63 ± 8495.84 ng/mL, P = 0.01).

Conclusion
Cardiovascular comorbidities are common among severe COVID-19 patients and increase the risk of ventricular arrhythmia, NLR value in AF and D-dimer level in any CV comorbidities, HF, and HHD patients.
OR53. Relation between platelet distribution width level with left ventricle global longitudinal strain on acute myocard infarct patient
Authors: Mahmud S , Wasyanto T 
Published: April 2022

Abstract

Background and aims
In patients with acute myocardial infarction (AMI), global longitudinal strain (GLS) is a more sensitive marker than left ventricular ejection fraction (LVEF) in assessing left ventricular function, and the prognostic impact of marker of platelet distribution width (PDW) has also been reported in this setting. The aim of this study was to investigate the relationship between PDW and GLS in patients with AMI.

Methods and results
A total of 38 patients with AMI (31 males and 7 females), both with ST segment elevation (STEMI) and non ST segment elevation (NSTEMI) were included. Blood samples were drawn at presentation and echocardiography was performed within 24 hours of presentation. Median PDW levels was 16.0%, and median GLS was -9.9%. A positive correlation was found between PDW levels and GLS (r = 0.339, p = 0.037).

Conclusion
Among patients with AMI, elevated PDW levels were associated with poor left ventricular function. This finding suggests that determining PDW levels within 24 hours following AMI may have beneficial prognostic value in predicting left ventricular function.
OR58. Six-minute walk test as a predictor of 1 year clinical outcome in patient presenting with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention
Authors: Khairat M , Vallerian W , Hanika R , Hamdani R , Krevani K C 
Published: April 2022

Abstract

Aim
Impairment of exercise capacity has a poor prognostic impact in post-myocardial infarct patient. The 6-minute walk test (6MWT) is a safe and simple methode that is used in assessing exercise capacity. However, there is limited data on the impact of 6MWT result as a prognosis in clinical outcome patient with ST-elevation myocardial infarct (STEMI). The aim of this study is to determine correlation between 6MWT result with 1 year clinical outcome (hospital readmission and death) of STEMI patients underwent PPCI

Methods
We obtained relevant and clinical data from our hospital database of 169 patients diagnosed with STEMI underwent PPCI procedure and performed 6MWT before hospital discharged during 2019. Patients were divided into 3 groups according to the level of 6MWT result (Level I: &lt;300m; Level II: 300-450m; Level III: &gt;450m). 1 year clinical outcome was obtained from medical record and direct contact to the patients. Statistical analysis was performed using SPSS

Result
Of the 169 patients included in the study population, the mean age was 58.73±9.88 year old, 122 males. Majority of patients was in level II (n = 50.3%) followed by level I (n = 32.0%) and level III (n = 17.8%). The highest readmission was in level I (n = 16.0%, p = 0,000). The highest mortality rate occurred in group II (n = 1.8%, p = 0,572)

Conclusion
6MWT that is performed before hospital discharged in STEMI patient undergoing PPCI have a correlation with 1 year clinical outcome, and appears to be a predictor of hospital readmission within 1 year
OR71. The relationship between daily intake of folic acid, vitamin B6, and vitamin B12 and ankle brachial index peripheral artery disease patients in Mataram
Authors: Qurniadi M T , Indrayana Y , Irawati D 
Published: April 2022

Abstract

Aims
The aim of this study was to determine the relationship between intake levels of folic acid, vitamin B6, and vitamin B12 with the value of the Ankle Brachial Index (ABI) in patients with peripheral artery disease in Mataram City.

Methods and Results
This study is a cross sectional study conducted at Siti Hajar Islamic Hospital in Mataram. The sample was patients with peripheral artery disease with an ABI value less than 0.90. The number of research samples was 52 subjects. Data Folic acid, vitamin B6, and vitamin B12 daily intake were collected using the 24-hours food recall method. The sampling technique used consecutive sampling method. Data analysis used the Spearman correlation test. The average daily intake of folic acid, vitamin B6, and vitamin B12 in the study sample wass less than 50% of the recommended daily nutritional adequacy rate for Indonesians. The average ABI in the sample was 0.79. The results of the Spearman correlation test between ABI and folic acid intake showed p value = 0.020 and r = 0.322. The results of the Spearman correlation test between the ABI and vitamin B6 intake showed p value = 0.167. The results of the Spearman correlation test between ABI and vitamin B12 intake showed p value = 0.800.

Conclusion
There is a significant relationship between ABI and folic acid intake. There is an insignificant relationship between ABI and vitamin B6 and vitamin B12.
OR78. The utility of shock index, modified shock index and age shock index to predict in-hospital mortality and icu admission in patients hospitalized with acute coronary syndrome
Authors: Niazta N A , Ardining H , Karimullah D H 
Published: April 2022

Abstract

Aims
The shock index (SI), the modified shock index (MSI), and the age shock index (ASI) are simple scales which can be obtained bedside. These scales have been studied to predict outcomes in various diseases. We aimed to evaluate the use of SI, MSI and ASI in patients hospitalized with acute coronary syndrome (ACS).

Method and Result
In this cross-sectional study, 102 patients who were admitted with ACS to Kediri General Hospital between January and June 2020 were included. Patients who presented with shock were excluded. We calculated for each patient the admission SI (defined as heart rate/systolic blood pressure), MSI (heart rate/mean arterial pressure), and ASI (age × SI). The mean SI was 0.70 ± 0.20, MSI was 0.95 ± 0.23 and ASI was 42.33 ± 14.17. Receiver-operating characteristic (ROC) curve analysis was used to assess the ability of SI, MSI and ASI to predict in-hospital mortality and ICU admission. The observed AUC of SI was 0.706 (95% CI 0.572-0.840), MSI was 0.705 (95% CI 0.58-0.83), and ASI was 0.687 (95% CI 0.540-0.834) in predicting in-hospital mortality. The cut-off point for SI was 0.75 with sensitivity of 69.2% and specificity of 67.4% in predicting in-hospital mortality. MSI demonstrated better C-statistics (0.665, 95% CI = 0.565 - 0.765) in predicting ICU admission.

Conclusion
SI had the best predictive value for in-hospital mortality compared with MSI and ASI, while MSI could predict ICU admission in patients with ACS.
M6. Effectiveness of Telemedicine Interventional Management in Adult With Heart Failure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Widhiarta P R , Sanjiwani N P G R 
Published: April 2022

Abstract

Aims
There is growing evidence that Telemedicine Interventional Management (TIM) can be advantageous in societies with an increasing prevalence of Heart Failure (HF). The objective of this meta-analysis was to assess the effectiveness of telemedicine intervention for patients with HF compared with conventional healthcare.

Method and Result
We systematically searched PubMed, MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials for randomized controlled trials (RCT) from January 2010 to December 2020. The primary effectiveness outcome was all-cause mortality. Secondary outcomes were all-cause hospitalization, cardiovascular mortality, and heart failure hospitalization. We include data from 15 RCTs comprising data for 11,262 patients. Telemedicine resulted in statistically significant risk reduction of all-cause mortality (OR 0.81, 95% CI 0.72–0.91, p = 0.0004). Receiving Telemedicine interventions is likely to reduce the hospitalization for all causes (OR 0.90, 95% CI 0.83-0.98, p = 0.02, I2 = 84%) and the hospitalization due to HF (OR 0.88, 95% CI 0.72-0.99, p = 0.04, I2 = 61%), compared with interventions from conventional healthcare. OR of telemedicine cardiac mortality (OR 0.82, 95% CI 0.70-0.97, p = 0.02, I2 = 0%).

Conclusion
Compare with conventional healthcare, telemedicine intervention combines with medical support prove to be more effective for HF adult, particularly in reducing all-cause mortality, all-cause hospitalization, cardiovascular mortality, and heart failure hospitalization. While further research is required to confirm these findings and identify optimal telemedicine strategies and the duration of follow-up for which it confers benefits.