bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sportive activity reduces genomic damage
Authors: Nota Alessandro , Santovito Alfredo 
Published: December 2022

Abstract
Purpose - The influence of training on the levels of genomic damage are not univocal, and to date not completely understood. Indeed, studies in this area remain scant and do not draw definitive conclusions. Our aim was to evaluate the influence of training on the levels of DNA damage in young athletes. We also wanted to explore the possibility of genomic damage to be driven by single-gene polymorphisms on metabolic and DNA repair genes in our sample.
Method - We compared the levels of Micronuclei and other nuclear aberrations in buccal mucosa cells of a group of 35 healthy, young martial artists with the ones of a group of 35 healthy, young sedentary controls. We also genotyped all subjects for three metabolic and two DNA repair genes in order to investigate the influence of the related single-gene polymorphisms on the frequency of genomic damage.
Results - We observed a decrease in the levels of genomic damage in athletes relatively to sedentary controls; this decrease was significant in both Micronuclei ant Total Aberrations. Instead, single-gene polymorphisms did not alter significantly the levels of nuclear aberrations.
Conclusion - The decrease in genomic damage observed in athletes suggests a protective effect of training and corroborates the beneficial effects of sportive activity on human health. Moreover, even other factors, such as the nature of the sport and training length, could influence the results.
LPA_SN:Label propagation algorithm based on the seed node in complex networks
Authors: Zhou HongFang , Li SuLi 
Published: December 2022

Abstract

Community detection is an essential technique in complex networks. In this paper, we propose a community detection algorithm based on label propagation. Before the propagation procedure, convert the unweighted network to an attribute graph. In this algorithm, we put forward a new seed node selection strategy.In the experiments, we validate our proposed algorithm on both real and attribute datasets.The experimental results demonstrate that our algorithm is more adaptable to the attribute dataset and has a better modularity.
Profiles of Suicide Attempted in Children and Adolescents in Cauca, Colombia 2016-2019
Authors: Ortega-Narváez Alicia , Muñoz Diana , Guzmán Claudia Patricia , Cabra-Bautista Ginna 
Published: December 2022

Abstract
Objective: Suicide attempt (SA) is the main predictive variable for completed suicide. The department of Cauca in Colombia has an SA rate higher than the national average, but the factors are unknown. The objective was to identify the profiles of SA in children and adolescents of Cauca.
Methods: Cross-sectional study, which included all SA (Event-356) records from the SIVIGILA platform in children under 18 years of age between 2016-2019. We described the variables and multiple correspondence analyses (MCA) with the Burt method for 2017-2019, according with the completeness of the data to establish the possible SA profiles using STATA 15.1, and R. The Ethics Committee at Universidad del Cauca approved it.
Results: The study found 977 SA during this period, 72.4% female, 97.1% adolescent, 74.4% mestizo, 19.3% indigenous, 45.3% resided in municipalities exposed to the armed conflict, 32.3% expressed ideation and previous attempts, and 15.5% prior attempts. The MCA included 810 SA and identified three profiles: “Classic”, which had mestizo adolescents with a history of prior SA, mental illness or psychoactive substance use problems; “Related to the armed conflict”, which included female adolescents with a first SA and residents in municipalities exposed to the armed conflict; “Ethnic” represented by male indigenous, with housing in a rural area.
Conclusion: The SA profiles found in Cauca were “Classic”, “Related to the armed conflict”, and “Ethnic”; these can be taken into account to implement prevention strategies from a cross-cultural, mental health, and gender perspective, with the presence of the state in the territories.
Kitchen waste biochar reduces inorganic nourishments of maize (Zea mays L.)
Authors: Ahmod Md. Moudud , Rahman Md. Sazidur , Moonmoon Sharifunnessa , Hossain Md. Sazzad , Hasan Md. Kamrul , Rahman Md. Masudur 
Published: December 2022

Abstract
Preparation of biochar from kitchen waste could be a potential way of waste management. This research aimed to prepare biochar and compost from kitchen waste and test their effects on the yield and biomass production of maize. We separated kitchen waste from municipal waste to prepare biochar, compost and ComBio (co-composting with biochar). Four fertilizer combinations viz. T0 = Recommended doses of chemical fertilizer (RDF), T1= biochar (20 t ha-1) + RDF, T2= compost (15 t ha-1) + 75% RDF and T3= ComBio (15 t ha-1) + 50% RDF were used to grow maize. Maize biomass, and yield attributing characters and basic soil properties after harvesting maize were measured. Data explored that up to 50% reduction of chemical fertilizer has an insignificant effect on the growth and biomass accumulation of maize. Similarly, yield and yield contributing characteristics of maize such as cob length, cob diameter, the weight of 1000-grains and yield did not vary among the treatments. Further, soil pH, EC, TDS and SOM contents were higher in biochar treated soil compared to other treatments. The results indicate that the application of biochar has the potential to reduce the chemical fertilizer dose of maize by improving soil properties, a prerequisite issue of sustainable crop production.
Detection of blaNDM-1 and blaOXA-23-like genes in carbapenem resistant Acinetobacter calcoaceticus-baumanii complex isolated from inpatients of Kathmandu Model Hospital, Nepal
Authors: Gurung Anupama , Shrestha Basudha , Lekhak Binod 
Published: December 2022

Abstract
Background
Acinetobacter calcoaceticus-baumannii (ACB) complex is a major nosocomial pathogen that is frequently involved in outbreaks of infection, occurring mostly in intensive care units. They have capacity to acquire resistance to various classes of antibiotics including carbapenems and hence emerged as one of the most common nosocomial pathogens of the present time.
Methods
This study was conducted to detect blaNDM-1, blaOXA-23-like, and blaOXA-24-like genes from carbapenem resistant Acinetobacter calcoaceticus-baumanii (CR-ACB) complex. This study was crossectional hospital-based study carried out in Kathmandu Model Hospital in which total of 992 representative inpatient samples were taken for the study and genetic works were performed in Centre for Health and Disease studies.
Results
Out of 992 samples, 43(4.33%) isolates were found to be ACB complex out of which 35 (81.4%) isolates were found to be carbapenem resistant. All CR-ACB complex were found sensitive towards polymixin B and colistin but tigecycline was effective in only 54.28% isolates. Thirty-three (94.28%) isolates gave positive MHT. Among 35 isolates of CR-ACB complex, 29(82.86%) isolates were positive for blaOXA-23-like gene and 12 (34.28%) isolates were positive for blaNDM-1 gene. However, all isolates were negative for blaOXA-24-like gene. Eleven (31.4%) of the isolates contained both blaOXA-23-like and blaNDM-1 genes which showed co-existence. Total 30 (85.7%) isolates were found to have carbapenemase genes.
Conclusion
Thus, the study showed that significant association between carbapenem resistance and genetic presence of carbapenemase genes although there are others parameters that are also responsible for carbapenem resistance.
Voices of First-Line Workers: A Qualitative Study of the Barriers and Facilitators in Working with Youth with Disruptive Behaviour (YDB)
Authors: Matthews Evan , Azar Rima , Doucet Shelley 
Published: December 2022

Abstract

BACKGROUND: Youth who exhibit disruptive behaviour may have serious conditions, such as conduct disorder or oppositional defiant disorder, which are often comorbid with clinical depression and substance abuse. Thus, it may be challenging to professionally care for them and their families.
OBJECTIVE: This study investigated the barriers and facilitators to supporting youth with disruptive behaviour in an urban city in Eastern Canada from the perspective of first-line workers.
METHODS: In the context of this study, first-line workers included police officers and youth workers (e.g., social workers and independent living program coaches). We conducted qualitative, semi-structured interviews over the telephone with eight first-line workers. Data was analyzed using thematic analysis.
RESULTS: Five major themes emerged from the data reflecting barriers in the daily work of first-line workers: (1) counterproductive youth behaviours; (2) emotional nature of the job; (3) insufficient services for youth; (4) other individuals in the lives of youth; and (5) minimal barriers as perceived by police. The facilitators that emerged from the data were: (1) support for youth and (2) support for workers.
CONCLUSIONS: In sum, this study indicated that, despite creative local multi-modal initiatives, services for youth with disruptive behaviour disorders remain under-funded or insufficient, and at times still incohesive in their delivery.
Health impacts of urban solid waste management problems in Asella town, Arsi zone, Oromia regional state, southeast, Ethiopia.
Authors: amde  
Published: December 2022

AbstractSolid wastes are substances by the owner of those properties. The increasing quantity of solid waste makes its management complicated issues. The main objective was to determine health impacts of solid waste management problems. A cross-sectional study design was selected during the data collection process. The sampling technic was randomly and systematically selected houses with a sample size of 423. The data collection tools were checklists, open and closed-ended questionnaires. Collected data entered into EPI data 4.6 and transported to Minitab 20.3 software. Both the chi-square and ANOVA tests were selected for statistical analysis purposes. The response of health impact assessment questions were 207 (49.5%) respiratory diseases, 76 (18.2%) asthmatic (bronchitis) cases, 66 (15.8%) diarrheal diseases, 62 (14.8%) protozoan diseases, and 7 (1.7% ) develop cancer cases. The responses to the environmental pollution responses were 143 (34.2%) water pollution, 132 (31.6%) air pollution, 56 (13.4%) soil pollution, and 87 (20.8%) global environmental problems. ANOVA test obtained strong relations with age groups, education, costs, and health impacts. The Chi-square test found strong associations exist between gender and solid waste sorting process. Therefore, improper solid waste management systems were found in diarrhoeal and parasitic disease episodes during the study of health problems in Asella, Ethiopia.
Post-Graduate Students’ Perceptions of Quillbot Utilization in English Academic Writing Class
Authors: Kurniati Eka Yuni , Fithriani Rahmah 
Published: December 2022

<em>Academic writing is currently a worldwide concern. A plethora of studies on academic writing difficulties in higher education has been conducted. With the advancement of technology, the challenges of academic writing can be alleviated by using Quillbot, an artificial intelligence (AI)-powered digital tool. However, research on using Quillbot in post-graduate academic writing classrooms is still limited, and little is known about how students perceive it. This study investigates how post-graduate students view Quillbot as a digital tool for English academic writing. This study employed a qualitative case study design by involving 20 post-graduate students majoring in English education who were already familiar with Quillbot to participate. In investigating the participants' perspectives, a questionnaire and semi-structured interview were used as the instruments for data collection. The findings reveal that the post-graduate students in this study responded positively to using Quillbot to assist them in improving the quality of their writing. Furthermore, the use of Quillbot was found to have three benefits: enhancing students' positive attitudes toward writing, providing a variety of user-friendly writing features, and aiding students' language development. This study implies that AI-powered technology like Quillbot in writing, particularly in academic writing, has a significant role in creating high-quality writing for students.</em>
A new multi-objective evolutionary algorithm for the optimization of water distribution networks
Authors: Palod Nikita , Prasad Vishnu , Khare Ruchi 
Published: December 2022

Abstract
This work introduces a new bi-objective optimization model for the design of a water distribution network (WDN). Reliability and design cost are two contradicting objectives that are optimized. The evolutionary technique multi-objective (MO) Jaya, hereafter referred as MO-JAYANET, is developed for the optimal design of WDN. EPANET is used as a hydraulic network solver in this study. The concept of constraint violation, dominance, non-dominance and crowding distance is used to develop MO-JAYANET. As the Jaya algorithm is a parameter-less technique, and with the concept of constraint dominance involved in the MO model, the penalty parameter required to penalize the non-feasible solution is also dropped. This makes MO-JAYANET a completely parameter-less technique, requiring no tuning at all. MO-JAYANET is applied on two benchmark networks from the literature using three different reliability indices that are Resilience Index, Network Resilience Index, and Modified Resilience Index. MO-JAYANET is found to be very easy and efficient for WDN optimization. The present work obtains a smooth Pareto Front (PF) that overlaps the best-known PF. The maximum reliability diameters obtained by the MO-JAYANET for the three indices are also simulated for both hydraulic and mechanical failures under different scenarios to identify a better-performing index.
Mechanism and efficiency of photocatalytic triclosan degradation by TiO2/BiFeO3 nanomaterials
Authors: Liu Gen , Lin Yingzi , Li Siwen , Shi Chunyan , Zhang Daihua 
Published: December 2022

Abstract
Hierarchical porous TiO2 photocatalytic nanomaterials were fabricated by impregnation and calcination using a peanut shell biotemplate, and TiO2/BiFeO3 composite nanomaterials with different doping amounts were fabricated using hydrothermal synthesis. The micromorphology, structure, element composition and valence state of the photocatalyst were analyzed using a series of characterization methods, including X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), BET surface area (BET), X-ray photoelectron spectroscopy (XPS), UV-visible diffuse reflectance (UV-vis), fluorescence spectroscopy (PL) and other technological means. Finally, the degradation mechanism and efficiency of BiFeO3 composite photocatalyst on the target pollutant triclosan were analyzed using a xenon lamp to simulate sunlight. The results showed that TiO2/BiFeO3 catalyst fabricated using a peanut shell biotemplate has a specific surface area of 153.64 m2/g, a band gap of 1.92 eV, and forms heterostructures. The optimum doping amount of TiO2/BiFeO3 catalyst was 1 mol/mol, and the degradation rate was 81.2%. The main active substances degraded were ·O2−and ·OH. The degradation process measured is consistent with the pseudo-first-order kinetic model.
Pharmacokinetics and Tissue Distribution of Nasal Spray of a Novel Muscarinic
Receptor Blocker, 101BHG-D01, in Dogs and Rats
Authors: Wei Hao , Wu Lei , Jia Yongliang , Shen Jian , Li Yanyou , Sun Peng , Xie Qiangmin , Chen Xiaoping , Xie Yicheng , Wang Yingshuo , Zhao Ziming 
Published: December 2022

Background:
101BHG-D01 is a novel selective anti-muscarinic (M) 3 receptor-blocking drug. 101BHGD01
nasal spray is intended to be used to relieve sneezing and runny nose symptoms caused by allergic rhinitis.

Methods:
In this study, we examined the plasma pharmacokinetics, tissue distribution, and major excretion mode of
101BHG-D01 in Beagle dogs and rats following nasal spray and intranasal administration, respectively, using HPLCMS/
MS.

Results/Discussion:
We found that the pharmacokinetics of 101BHG-D01 was linear in dogs. 101BHG-D01 entered
the bloodstream rapidly following nasal spray. Its plasma half-life was approximately 6 h and resided at least 24 h in
the body. Moreover, 101BHG-D01 retained a significant amount in the nasal cavity. Finally, we found that 101BHGD01
was eliminated mainly in the form of stools in rats.

Conclusion:
In conclusion, we provided pertinent reference information regarding the design and optimization of
drug delivery regimens for clinical trials.
Thymosin β4 and Actin: Binding Modes, Biological Functions and Clinical
Applications
Authors: Gao Jianli , Ying Yuyuan , Lin Chen , Tao Nana , Hoffman Robert D. , Shi Dongling , Chen Zhijin 
Published: December 2022

Abstract:
Thymosin β4 (Tβ4) is the β-thymosin (Tβs) with the highest expression level in human
cells; it makes up roughly 70-80% of all Tβs in the human body. Combining the mechanism and activity
studies of Tβ4 in recent years, we provide an overview of the subtle molecular mechanism, pharmacological
action, and clinical applications of Tβ4. As a G-actin isolator, Tβ4 inhibits the polymerization
of G-actin by binding to the matching site of G-actin in a 1:1 ratio through conformational and
spatial effects. Tβ4 can control the threshold concentration of G-actin in the cytoplasm, influence the
balance of depolymerization and polymerization of F-actin (also called Tread Milling of F-actin), and
subsequently affect cell's various physiological activities, especially motility, development and differentiation.
Based on this, Tβ4 is known to have a wide range of effects, including regulation of inflammation
and tumor metastasis, promotion of angiogenesis, wound healing, regeneration of hair follicles,
promotion of the development of the nervous system, and improving bone formation and tooth growth.
Tβ4 therefore has extensive medicinal applications in many fields, and serves to preserve the kidney,
liver, heart, brain, intestine, and other organs, as well as hair loss, skin trauma, cornea repairing, and
other conditions. In this review, we focus on the mechanism of action and clinical application of Tβ4
for its main biological functions.
Effects of Metformin on Modulating the Expression of Brain-related Genes
of APP/PS1 Transgenic Mice based on Single Cell Sequencing
Authors: Qiu-Yue Xiao , Tian-Yuan Ye , Xiao-Long Wang , Dong-Mei Qi , Xiao-Rui Cheng 
Published: December 2022

Background:
Alzheimer's disease is the most common form of dementia, affecting millions
of people worldwide.

Methods:
Here, we analyzed the effects of metformin on APP/PS1 transgenic mice by behavioral test
and single-cell sequencing.

Results:
It showed that metformin can improve the spatial learning, memory function, and anxiety
mood of APP/PS1 transgenic mice. We identified transcriptionally distinct subpopulations of nine
major brain cell types. Metformin increased the differentiation of stem cells, decreased the proportion
of cells in the G2 phase, enhanced the generation of neural stem cells and oligodendrocyte progenitor
cells, and the tendency of neural stem cells to differentiate into astrocytes. Notably, 253 genes expressed
abnormally in APP/PS1 transgenic mice and were reversed by metformin. Ttr, Uba52, and
Rps21 are the top 3 genes in the cell-gene network with the highest node degree. Moreover, histochemistry
showed the expressions of RPS15, Uba52, and RPL23a were consistent with the data from
single-cell sequencing. Pathway and biological process enrichment analysis indicated metformin was
involved in nervous system development and negative regulation of the apoptotic process.

Conclusion:
Overall, metformin might play an important role in the differentiation and development
and apoptotic process of the central nervous system by regulating the expression of Ttr, Uba52,
Rps21, and other genes to improve cognition of APP/PS1 transgenic mice. These results provided a
clue for elaborating on the molecular and cellular basis of metformin on AD.
Stem Cell Therapy in Combination with Naturopathy: Current Progressive
Management of Diabetes and Associated Complications
Authors: Saha Aloke , Samadder Asmita , Nandi Sisir 
Published: December 2022

Background:
Diabetes is a chronic metabolic disorder having a global prevalence of nearly doubled over the last 30 years and has become one of the major health concerns worldwide. The number of adults with diabetes increased to 537 million in 2021.

Introduction:
The overarching goal of diabetic research and treatment has always been to restore insulin independence and an average blood glucose level. Chemotherapeutic antidiabetic agents can manage diabetes but often show toxicity and drug resistance. Natural phytomedicines may be useful along with stem cell therapy for diabetes management. Even if the whole pancreatic organ and islet transplantation, are becoming benchmark techniques for diabetes management and control, a con-siderable scarcity of eligible donors of pancreatic tissues and organs severely limits their use. Stem cell treatment provides a bunch of possibilities for treating people with diabetes.

Methods:
For this purpose, comprehensive article searching was conducted, with relevant material obtained using search engines such as Scopus, PubMed, MEDLINE, Google, and others, using ap-propriate keywords.

Results:
Stem cell therapies, including induced pluripotent stem cells and mesenchymal stem cells, are now becoming a popular area of investigation. Recent advancements in stem cell therapy might provide a feasible treatment option. Furthermore, in recent years, some novel bioactive compounds derived from plants have demonstrated antidiabetic action with higher potency than oral hypogly-caemic medications. Recent regenerative medicine and stem cell treatment advancements might subsequently provide a feasible diabetic management option. On the other hand, medicinal herbs have been considered a better choice for the extensive treatment of diabetes.

Conclusion:
If proper attention is not given to control diabetes by antidiabetic chemotherapeutic agents, natural phytomedicine, and sophisticated treatment like stem cell therapy, then the lifespan of patients will be decreased, and some associated secondary problems will also arise. So, the pre-sent review attempts to discuss naturopathy as an alternative resource in combination with stem cell therapy for the progressive management of diabetes and associated disorders.
Chemistry of Medicinally Important Dihydropyrimidinone-based Heterocycle
Scaffolds
Authors: Versha  , Rana Ravi Kumar , Bendi Anjaneyulu 
Published: December 2022

Abstract:
In medicinal chemistry, Dihydropyrimidinone-based heterocycle scaffolds have attained a
prominent place due to their enormous pharmacological and biological activities. The discovery and
development of innovative drugs to combat a wide range of diseases exemplify the utility of these
compounds. The present study summarizes the variety of methods available to synthesize various dihydropyrimidinone-
based heterocycle scaffolds and their beneficial medicinal properties with the
available literature until 2022.