bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular mechanisms and enhanced functions of Hibiscus sabdariffa L—nanoliposomes as an emerging therapeutic strategy in UV and galactosamine skin aging-induced model
Authors: Nassar Eptehal , Rady Mai , Handousa Heba 
Published: January 2025

Abstract
Background
Skin aging is a multifactorial disorder that occurs due to extrinsic and intrinsic factors, where a decrease in natural antioxidant defenses and an imbalance between molecular biomarkers occur. The current study aims to develop nanoliposomes for the dermal delivery of Hs and to investigate their effects on skin biomarkers and skin aging.

Methods
Chemical profiling performed via high-performance liquid chromatography (HPLC)/ESI‒PDA‒MS revealed enrichment in phenolic metabolite contents. Hs-nanolopeosomes were characterized for their mean size, encapsulation efficiency of Hs and ability to penetrate the skin via confocal microscopy. An aged rat model generated via UV and galactosamine injection was evaluated for reduced glutathione (GSH) and malondialdehyde (MDA) levels, in addition to the levels of collagenase and elastase enzymes in the different study groups, which included a healthy control group, an aged group, a prophylactic group, an aged group treated with Hs-nanoliposomes, and a green tea extract-treated group (positive control). Moreover, the Bcl-2/Bax proteins were determined via ELISA, and MMP-1, MMP-2, MMP-9, and TIMP-1 expression was determined via RT‒qPCR in the study groups.

Results
Hs-nanoliposomes (~ 400 nm) proved deep skin localization in confocal images. Compared with the aged group and the green tea extract-treated group, the Hs-liposome-treated group presented elevated reduced glutathione and decreased malondialdehyde levels and inhibited collagenase and elastase enzymes. This treatment also decreased the Bcl-2/Bax ratio and downregulated the expression of MMP-1, MMP-2, and MMP-9. However, upregulation of TIMP-1 expression was detected. The outcomes were confirmed by histopathological assays, which revealed reduced saging and collagen damage in the Hs-nanolipid-treated group.

Conclusion
The present study proposed a potential antiaging nanobased formulation that can deliver Hs extract deep in the dermis layer to prevent the oxidative stress that leads to aging.
Synopsis of colorectal cancer: prevalence, symptoms, screening, staging, risk factors, and treatment
Authors: Balata Gehan F. , Azzam Hany N. 
Published: January 2025

AbstractColorectal cancer (CRC) impacts the colon and rectum, ranking as the fourth deadliest cancer worldwide, accounting for 10% of cancer cases and 9.4% of cancer-related deaths. CRC is frequently without symptoms until it reaches its later stages. Screening programs, including colonoscopies and tests on stool samples, have enhanced the chances of survival for people younger than fifty. The TNM staging system, which evaluates tumor size, lymph node involvement, and metastasis, is commonly utilized. Factors that increase the risk of developing colorectal cancer include exposure to chemicals, chronic inflammatory bowel disease, obesity, smoking, family history, genetic mutations, and specific diets. Diets high in fat, consumption of too much iron, sugary beverages, and meals with high sugar content can elevate the risk of CRC, whereas incorporating whole grains, fiber, calcium, vitamin D, dairy products, vegetables, fruits, and green tea into your diet can lower the risk. Management differs depending on stage: stages 0 and I are treated with endoscopy and local excision, whereas stages II, III, and IV necessitate systemic treatments like immunotherapy, targeted therapy, and chemotherapy.
Simultaneous gastroepiploic artery to right coronary artery bypass and trans-catheter aortic valve implantation: case series
Authors: Honda Kentaro , Wada Teruaki , Kunimoto Hideki , Nishimura Yoshiharu 
Published: January 2025

AbstractPatients with coronary artery disease undergoing trans-catheter aortic valve implantation (TAVI) often receive TAVI alone. However, in cases of severe coronary lesions or anticipated difficulty in coronary access post-TAVI, percutaneous coronary intervention or coronary artery bypass grafting may be necessary. We performed simultaneous gastroepiploic artery to posterior descending artery bypass and TAVI in two patients with severe calcification of the right coronary artery ostium which is unsuitable for percutaneous intervention. The procedure was conducted through an upper median laparotomy, avoiding a full sternotomy. Patients were discharged on postoperative days 6 and 9, respectively. By combining minimally invasive techniques and avoiding median sternotomy, we achieved favorable outcomes without compromising the less invasive nature of TAVI. This approach demonstrates the potential for tailored, hybrid procedures in high-risk patients with concomitant aortic valve disease and complex coronary lesions.
Refining Stereotaxic Deep Brain Stimulation Surgery Procedures for Parkinson Disease in Pursuit of Zero Pneumocephalus: 2-Dimensional Operative Video
Authors: Wang Ran , Liu Kaiyu , Yu Feng , Guo Liemei , Ma Junfeng , Chai Yi , Zhang Xiaohua , Zhou Hongyu 
Published: January 2025

BACKGROUND AND OBJECTIVES:
Deep brain stimulation (DBS) is a well-established intervention for alleviating both motor and nonmotor symptoms of Parkinson disease. However, a common complication of stereotaxic DBS surgery is pneumocephalus, which can compromise electrode accuracy, complicate postoperative assessments, and negatively affect the long-term outcomes of DBS surgery. This report proposes a comprehensive and robust set of recommendations aimed at optimizing DBS surgical protocols to achieve zero pneumocephalus outcomes.

METHODS:
A retrospective analysis was undertaken on 138 patients with Parkinson disease who underwent simultaneous bilateral stereotaxic DBS targeting either the subthalamic nucleus or the globus pallidus internus at a single institution. The study compared the pneumocephalus volume and postsurgical electrode tip displacement between the original surgical technique and a refined procedure that incorporated modified supine position, dural puncture, and liquid sealing.

RESULTS:
With the implementation of the refined procedure, the volume of pneumocephalus significantly decreased from 14.40 ± 17.00 to 0.32 ± 1.02 mL, with 92.9% of patients showing no visible pneumocephalus or intracranial air less than 1 mL. In addition, the refined procedure was associated with less electrode tip displacement in the postoperative stage.

CONCLUSION:
The refined procedure effectively minimized the average pneumocephalus volume to approximately 0, and bilateral DBS electrodes exhibited enhanced stability during the postoperative stage.
A Comparison of Decompression Size and Craniectomy Speed of Reverse Question Mark Versus Retroauricular Incisions for Decompressive Hemicraniectomy: A Cadaver Study
Authors: McIntyre Matthew K. , Ross Miner , Godil Jamila , Gerges Christina , Yamamoto Erin A. , Siler Dominic , Orina Josiah , Wright James 
Published: January 2025

BACKGROUND AND OBJECTIVES:
Decompressive hemicraniectomy is a common emergent surgery for patients with stroke, hemorrhage, or trauma. The typical incision is a reverse question mark (RQM); however, a retroauricular (RA) incision has been proposed as an alternative. The widespread adoption ofthe RA incision has been slowed by lack of familiarity and concerns over decompression efficacy. Our goal is to compare the RA vs RQM incisions regarding decompression safety and to examine skill acquisition among resident neurosurgeons.

METHODS:
Six cadaveric heads were randomized to first receive either RQM or RA decompressive hemicraniectomy, which was followed by use of the other incision on the contralateral side. Primary endpoints were decompression circumference and time to bone flap removal. Resident neurosurgeon (postgraduate year 3 through 7) confidence and operative times were compared.

RESULTS:
All craniectomies yielded decompression diameters >13 cm (RQM: 13.5-15.5 cm; RA: 13.0-16.5 cm) and residual temporal bone heights <1.5 cm (RQM: 0.5-1.3 cm; RA: 0.5-1.5 cm). There were no differences between the RA and RQM groups in decompression circumference (P = .6605), residual temporal bone height (P = .7121), or time from incision until bone flap removal (P = .8452). There was a nonsignificant trend toward a shorter incision length with RA (RQM: 37.7 ± 0.7 cm vs RA: 35.1 ± 0.9; P = .0729). Regardless of which incision was performed first, operative time significantly improved from the first craniectomy to the second (−174.6 seconds, P = .0186). Surgeon confidence improved more with the RA incision, and there was a linear association with experience and time to bone flap removal in the RQM (P = .04) but not the RA (P = .95) groups.

CONCLUSION:
The RA incision may provide adequate operative exposure without significant changes in operative time. Cadaveric labs improve skill acquisition and should be considered during implementation of novel surgical approaches into practice.
Impact of Gonadotropin-releasing Hormone Analogue and Gender-affirming Hormone Therapy on Bone Mineral Density in Transgender Adolescents
Authors: Chuncia-Ileczko Marta , Czyż Witold , Kacperczyk Julia , Arczewski Filip , Dziedzic Karol , Kulbacka Julia , Wojszczyk Maciej , Zys Damian , Pasek Piotr , Ryniecka Julia 
Published: January 2025

Background: Sex hormones have a key impact on the development of the human body during puberty, including a significant influence on bone development - their shape, structure, length, and mineral density. Due to the growing number of transgender and gender diverse (TGD) adolescents and the increasing demand for gender-affirming hormone therapy (GAHT), there is rising curiosity about the impact of this therapy on the developing body of a young person.
Purpose: This review aims to summarize the latest scientific reports on the impact of gonadotropin-releasing hormone analogues (GnRHas) and GAHT on the bone mineral density (BMD) of transgender adolescents undergoing gender-changing therapies.
Findings: Low pretreatment BMD is more common among TGD adolescents than in the general population, and this is more prevalent in transgirls than in transboys. BMD Z-scores decline during treatment with GnRHas and respond differentially to GAHT. Regular follow-up and health advice are essential. Further long-term studies of the effects of these therapies on peak bone mass and future fracture risk are needed.
Deep Policy Iteration with Integer Programming for Inventory Management
Authors: Harsha Pavithra , Jagmohan Ashish , Kalagnanam Jayant , Quanz Brian , Singhvi Divya 
Published: January 2025

Problem definition: In this paper, we present a reinforcement learning (RL)-based framework for optimizing long-term discounted reward problems with large combinatorial action space and state dependent constraints. These characteristics are common to many operations management problems, for example, network inventory replenishment, where managers have to deal with uncertain demand, lost sales, and capacity constraints that results in more complex feasible action spaces. Our proposed programmable actor RL (PARL) uses a deep-policy iteration method that leverages neural networks to approximate the value function and combines it with mathematical programming and sample average approximation to solve the per-step-action optimally while accounting for combinatorial action spaces and state-dependent constraint sets. Methodology/results: We then show how the proposed methodology can be applied to complex inventory replenishment problems where analytical solutions are intractable. We also benchmark the proposed algorithm against state-of-the-art RL algorithms and commonly used replenishment heuristics and find that the proposed algorithm considerably outperforms existing methods by as much as 14.7% on average in various complex supply chain settings. Managerial implications: We find that this improvement in performance of PARL over benchmark algorithms can be directly attributed to better inventory cost management, especially in inventory constrained settings. Furthermore, in the simpler setting where optimal replenishment policy is tractable or known near optimal heuristics exist, we find that the RL-based policies can learn near optimal policies. Finally, to make RL algorithms more accessible for inventory management researchers, we also discuss the development of a modular Python library that can be used to test the performance of RL algorithms with various supply chain structures. This library can spur future research in developing practical and near-optimal algorithms for inventory management problems. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.0617 .
Protocolos de aconselhamento em aleitamento materno: revisão de escopo
Authors: Coimbra Joyce Silva , Resende Cynthya Viana de , Cavalcanti Michele Curcino , Rodrigues Elisa da Conceição , Wernet Monika , Ruiz Mariana Torreglosa 
Published: January 2025

Objetivo: mapear evidências disponíveis na literatura sobre protocolos utilizados no aconselhamento em aleitamento materno. Método: revisão de escopo com buscas realizadas em março de 2023, atualizadas em fevereiro de 2024, independentemente nas bases: PubMed/MEDLINE, LILACS, Scopus, Embase, Web of Science; CINAHL, Catálogo de Teses e Dissertações da CAPES e Cochrane Library, correlacionando os descritores Counseling, Breast Feeding, Education, Guideline e Protocol e sinônimos, sem delimitação de tempo e idioma. Resultados: a amostra final foi composta por 11 estudos, de 2003 a 2022, com predomínio do idioma inglês e do tipo ensaio clínico randomizado, aplicação mais frequente no puerpério e entre binômios com condições favoráveis ao aleitamento. Aplicados em sessões individuais ou grupais, com duração de 20-60 minutos e uso de material de apoio, sendo os enfermeiros, os profissionais mais citados. Conclusão: observou-se a escassez de pesquisas que detalham protocolos de aconselhamento em aleitamento materno, com predomínio da aplicação dos protocolos no puerpério.
FORMAÇÃO DE ENFERMEIROS NA ERA DIGITAL: transmídias, inclusão digital e extensão universitária
Authors: Furtado Rita de Cássia Serra , Ribeiro Nayure Lopes , Lacerda Rúbia Gabriela Ferreira , Moraes Elane Batista , Rodrigues Leovana dos Santos , Almeida Raíssa Moura de , Souza Jamily Silva , Castro Nádile Juliane Costa de 
Published: January 2025

Introdução: A saúde e educação de qualidade, a partir de ações inclusivas previstas nas metas dos globais, se integram na formação de enfermeiros, ancoradas nas Diretrizes Curriculares Nacionais de graduação em Enfermagem (DCENf) para o aperfeiçoamento de habilidades cognitivas complexas, como o pensamento crítico e a resolução de problemas. Nesse sentido, a integração dos recursos digitais3 na formação em enfermagem não apenas promove habilidades necessárias para navegar no futuro digital da saúde. Objetivo: Analisar processos transmidiáticos que tenham como princípio fomentar a inclusão digital entre estudantes de enfermagem. Método: Estudo descritivo, exploratório e documental. A fonte dos dados foram o relatório 2023 e as mídias sociais de um projeto de extensão universitário de um edital cujo objeto de ação é a inclusão digital. Resultados: Os conteúdos foram criados a partir de editores de imagens, compartilhados por diferentes mídias sociais e tiveram participação de dez estudantes do terceiro ao sétimo semestre, três mestrandos e quatro docentes facilitadores. Foram identificadas três tipologias em ordem sequencial para divulgação dos conteúdos: card, podcast e videográficos que dialogavam entre si sobre o mesmo tema para pautar o objeto de estudo de um artigo científico. Conclusões: A integração da transmídia e da inclusão digital na formação em enfermagem representa um paradigma emergente e fica evidente que as estratégias transmidiáticas não apenas enriquecem o processo de aprendizagem com experiências multimodais e interativas, mas também preparam os futuros profissionais de enfermagem para atuar em um cenário de saúde cada vez mais digitalizado e interconectado
Does HIV status affect attitudes on welfare deservingness? A survey experiment on welfare policy in the US
Authors: Witkowski Kaila , Neely Stephen R. 
Published: January 2025

Studies examining welfare recipients’ deservingness are becoming increasingly more important as the US continues to debate access to unemployment benefits and make access to Medicaid more conditional. While there has been extensive research on the deservingness of some groups of welfare recipients, the intersection of HIV-related stigma and welfare deservingness has not been heavily studied since the early 2000s, leaving gaps in our knowledge of the current perceptions of deservingness, especially in light of medical breakthroughs in HIV treatments. In this study, we use an experimental vignette to assess the impact of HIV-related stigma on the perception of an HIV patient’s deservingness when it comes to unemployment and Medicaid benefits in Florida (n = 600). While HIV status does not appear to be a disqualifying factor, respondents were less likely to support the allocation of welfare benefits when the vignette attributed HIV treatment as the reason for unemployment. The results of this study highlight the impact that medical stigma can have on the deservingness of welfare recipients. This research makes an important contribution to our understanding of deservingness and enhances insights into how medical conditions generally and HIV, specifically, shape attitudes.
Telehealth equity and access communication skills pilot simulation for practicing clinicians
Authors: Nash Christopher J. , Farrell Susan E. , Carreras Tartak Jossie A. , Wagner Alexei , Brandt Lea C. , Hayden Emily M. 
Published: January 2025

Objectives
This pilot study evaluated a telehealth training simulation program for practicing clinicians, specifically focused on addressing patient issues of equity and access to healthcare via improving telehealth communication.

Methods
Participants participated in a one-hour simulation experience with two cases. Performance was assessed pre- and post-intervention using a checklist measuring communication domains related to equity and access in telehealth. Participant satisfaction was secondarily measured via survey.

Results
Results showed measurable gains in clinicians’ abilities to effectively incorporate equity and access communication skills. Participants found the session useful and recommended the training experience.

Conclusions
The findings of this pilot study highlight the potential of simulation-based telehealth training for practicing clinicians, emphasizing clinicians’ attention to patients’ equitable access to healthcare. Future studies should aim to explore the durability of learning and investigate the generalizability of this training approach to other telehealth competencies and settings.
ETL: From the German Health Data Lab data formats to the OMOP Common Data Model
Authors: Finster Melissa , Moinat Maxim , Taghizadeh Elham 
Published: January 2025

Objective
The German Health Data Lab is going to provide access to German statutory health insurance claims data ranging from 2009 to the present for research purposes. Due to evolving data formats within the German Health Data Lab, there is a need to standardize this data into a Common Data Model to facilitate collaborative health research and minimize the need for researchers to adapt to multiple data formats. For this purpose we selected transforming the data to the Observational Medical Outcomes Partnership Common Data Model.

Methods
We developed an Extract, Transform, and Load (ETL) pipeline for two distinct German Health Data Lab data formats: Format 1 (2009-2016) and Format 3 (2019 onwards). Due to the identical format structure of Format 1 and Format 2 (2017 -2018), the ETL pipeline of Format 1 can be applied on Format 2 as well. Our ETL process, supported by Observational Health Data Sciences and Informatics tools, includes specification development, SQL skeleton creation, and concept mapping. We detail the process characteristics and present a quality assessment that includes field coverage and concept mapping accuracy using example data.

Results
For Format 1, we achieved a field coverage of 92.7%. The Data Quality Dashboard showed 100.0% conformance and 80.6% completeness, although plausibility checks were disabled. The mapping coverage for the Condition domain was low at 18.3% due to invalid codes and missing mappings in the provided example data. For Format 3, the field coverage was 86.2%, with Data Quality Dashboard reporting 99.3% conformance and 75.9% completeness. The Procedure domain had very low mapping coverage (2.2%) due to the use of mocked data and unmapped local concepts The Condition domain results with 99.8% of unique codes mapped. The absence of real data limits the comprehensive assessment of quality.

Conclusion
The ETL process effectively transforms the data with high field coverage and conformance. It simplifies data utilization for German Health Data Lab users and enhances the use of OHDSI analysis tools. This initiative represents a significant step towards facilitating cross-border research in Europe by providing publicly available, standardized ETL processes (https://github.com/FraunhoferMEVIS/ETLfromHDLtoOMOP) and evaluations of their performance.
Unveiling the efficacy of repetitive transcranial magnetic stimulation in Parkinson’s disease: A comprehensive review of systematic analyses
Authors: Zhang Lingwen , Jiang Yanhong , Fan Wenhui , Xue Hua 
Published: January 2025

Background
Many systematic reviews (SRs) have reported the repetitive transcranial magnetic stimulation (rTMS) for Parkinson’ s disease (PD), but the quality of the evidence is unclear. The aim of this study was to summarize the evidence provided by SRs on the effect of rTMS on PD.

Methods
A comprehensive search for SRs published from the establishment of the library to March 1, 2024, was conducted in PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, VIP and Wanfang databases. The A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR-2), the Risk of Bias for Systematic Reviews (ROBIS), and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool were used to evaluate the methodology quality, risk of bias and evidence quality of SRs, respectively.

Results
We identified 16 SRs. According to the results of the AMSTAR-2, 12.5% (2/16) of the SRs rated as high quality, 43.75% (7/16) rated as low quality, and 43.75% (7/16) rated as very low quality. Based on the ROBIS tool, 6 (37.5%) SRs had low risk of bias. The GRADE results suggested that 16.13% (10/62) of the evidence was of moderate quality, 33.87% (21/62) of the evidence was of low quality and 50% (31/62) of the evidence was of very low quality. Moderate-quality results show that rTMS can improve PD motor symptoms.

Conclusions
Here we show that rTMS can improve the motor symptoms of PD, but its effectiveness in treating non-motor symptoms of PD is inconsistent. Due to the methodological limitations and diversity in study designs, future studies should focus on addressing these issues by providing thorough methodological details, standardizing rTMS protocols, evaluating side effects, and comparing with other treatments.