bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radial and Axial Motion of the Initially Tensioned Orthotropic Arterial Wall in Arterial Pulse Wave Propagation
Authors: Smith Sara M. , Marin Justine , Adams Amari , West Keith , Hao Zhili 
Published: February 2022

AbstractWith the arterial wall modeled as an initially tensioned thin-walled orthotropic tube, this study aims to analyze radial and axial motion of the arterial wall and thereby reveal the role of axial motion and two initial tensions of the arterial wall in arterial pulse wave propagation. By incorporating related clinical findings into the pulse wave theory in the literature, a theoretical study is conducted on arterial pulse wave propagation with radial and axial wall motion. Since the Young wave is excited by pulsatile pressure and is examined in clinical studies, commonly measured pulsatile parameters in the Young wave are expressed in terms of pulsatile pressure and their values are calculated with the well-established values of circumferential elasticity (Eθ) and initial tension (Tθ0) and assumed values of axial elasticity (Ex) and initial tension (Tx0) at the ascending aorta and the carotid artery. The corresponding values with the exclusion of axial wall motion are also calculated. Comparison of the calculated results between inclusion and exclusion of axial wall motion indicates that (1) axial wall motion does not affect radial wall motion and other commonly measured pulsatile parameters, except wall shear stress; (2) axial wall motion is caused by wall shear stress and radial wall displacement gradient with a factor of (Tx0−Tθ0), and enables axial power transmission through the arterial wall; and (3) while radial wall motion reflects Eθ and Tθ0, axial wall motion reflects Ex and (Tx0−Tθ0).
Study of Residual Stress Evolution in SUS304/Q235 Bimetallic Clad Plate Butt-Welded Joints Considering Welding Sequence
Authors: Zhu Min , Zhang Yansong , Zheng Qiao , Wu Wei , Qian Weifang , Wang Baosen 
Published: February 2022

Abstract
Residual stress prediction and controlling is important for structural integrity assessment of weldments. In this work, finite element (FE) and experimental methods were integrated to study the influence of welding sequence on the SUS304/Q235 bimetallic clad plate (BCP) joints during multilayer and multipass welding. The results show that the peak residual stress values on flyer plate surface are weakly affected by welding sequences but the width of high surficial longitudinal stress area of joint with base layer welded first is bigger. Meanwhile, welding sequence has a great influence on the longitudinal residual stress evolution law inside joints. When base seam layer is welded first, the highest stress concentration appears in the transition layer. However, it would be transferred into the first base seam layer due to martensite phase transformation when flyer seam layer is welded first. Residual stress controlling in the BCP joint should attract more attention from researchers.
Comparison of the V&V10.1 and V&V20 Modeling Error Quantification Procedures for the V&V10.1 Example
Authors: Eça L. , Dowding K. , Moorcroft D. , Ghia U. 
Published: February 2022

Abstract
The determination of the transverse tip deflection of an elastic, hollow, tapered, cantilever, box beam under a uniform loading applied over half the length of the beam presented in the V&V10.1 standard is used to compare the application of the validation procedures presented in the V&V10.1 and V&V20 standards. Both procedures aim to estimate the modeling error of the mathematical/computational model used in the simulations taking into account the variability of the modulus of elasticity of the material used in the beam and the rotational flexibility at the clamped end of the beam. The paper discusses the four steps of the two error quantification procedures: (1) characterization of the problem including all the assumptions and approximations made to obtain the experimental and simulation data; (2) selection of the validation variable; (3) determination of the different quantities required by the validation metrics in the two error quantification procedures; (4) outcome of the two validation procedures and its discussion. The paper also discusses the inclusion of experimental, input, and numerical uncertainties (assumed or demonstrated to be negligible in V&V10.1) in the two validation approaches. This simple exercise shows that different choices are made in the two alternative approaches, which lead to different ways of characterizing the modeling error. The topics of accuracy requirements and validation comparisons (model acceptance/rejection) for engineering applications are not addressed in this paper.
Prognostic effect of body mass index in patients with advanced NSCLC treated with chemoimmunotherapy combinations
Authors: Cortellini Alessio , Ricciuti Biagio , Vaz Victor R , Soldato Davide , Alessi Joao V , Dall’Olio Filippo G , Banna Giuseppe L , Muthuramalingam Sethupathi , Chan Samuel , Majem Margarita , Piedra Aida , Lamberti Giuseppe , Andrini Elisa , Addeo Alfredo , Friedlaender Alex , Facchinetti Francesco , Gorría Teresa , Mezquita Laura , Hoton Delphine , Valerie Lacroix , Nana Frank Aboubakar , Artingstall James , Comins Charles , Di Maio Massimo , Caglio Andrea , Cave Judith , McKenzie Hayley , Newsom-Davis Thomas , Evans Joanne S , Tiseo Marcello , D'Alessio Antonio , Fulgenzi Claudia A M , Besse Benjamin , Awad Mark M , Pinato David J 
Published: February 2022

IntroductionIt has been recognized that increasing body mass index (BMI) is associated with improved outcome from immune checkpoint inhibitors (ICIs) in patients with various malignancies including non-small cell lung cancer (NSCLC). However, it is unclear whether baseline BMI may influence outcomes from first-line chemoimmunotherapy combinations.MethodsIn this international multicenter study, we evaluated the association between baseline BMI, progression-free survival (PFS) and overall survival (OS) in a cohort of patients with stage IV NSCLC consecutively treated with first-line chemoimmunotherapy combinations. BMI was categorized according to WHO criteria.ResultsAmong the 853 included patients, 5.3% were underweight; 46.4% were of normal weight; 33.8% were overweight; and 14.5% were obese. Overweight and obese patients were more likely aged ≥70 years (p=0.00085), never smokers (p<0.0001), with better baseline Eastern Cooperative Oncology Group—Performance Status (p=0.0127), and had lower prevalence of central nervous system (p=0.0002) and liver metastases (p=0.0395). Univariable analyses showed a significant difference in the median OS across underweight (15.5 months), normal weight (14.6 months), overweight (20.9 months), and obese (16.8 months) patients (log-rank: p=0.045, log rank test for trend: p=0.131), while no difference was found with respect to the median PFS (log-rank for trend: p=0.510). Neither OS nor PFS was significantly associated with baseline BMI on multivariable analysis.ConclusionsIn contrast to what was observed in the context of chemotherapy-free ICI-based regimens, baseline BMI does not affect clinical outcomes from chemoimmunotherapy combinations in patients with advanced NSCLC.
Supertwistor realisations of AdS superspaces
Authors: Kuzenko Sergei M. , Tartaglino-Mazzucchelli Gabriele 
Published: February 2022

AbstractWe propose supertwistor realisations of (p, q) anti-de Sitter (AdS) superspaces in three dimensions and $${\mathcal {N}}$$
N
-extended AdS superspaces in four dimensions. For each superspace, we identify a two-point function that is invariant under the corresponding isometry supergroup. This two-point function is a supersymmetric extension (of a function) of the geodesic distance. We also describe a bi-supertwistor formulation for $${\mathcal {N}}$$
N
-extended AdS superspace in four dimensions and harmonic/projective extensions of (p, q) AdS superspaces in three dimensions.
Reproduced Computational Results Report for “Ginkgo: A Modern Linear Operator Algebra Framework for High Performance Computing”
Authors: Balos Cody J. 
Published: February 2022

The article titled “Ginkgo: A Modern Linear Operator Algebra Framework for High Performance Computing” by Anzt et al. presents a modern, linear operator centric, C++ library for sparse linear algebra. Experimental results in the article demonstrate that Ginkgo is a flexible and user-friendly framework capable of achieving high-performance on state-of-the-art GPU architectures.
In this report, the Ginkgo library is installed and a subset of the experimental results are reproduced. Specifically, the experiment that shows the achieved memory bandwidth of the Ginkgo Krylov linear solvers on NVIDIA A100 and AMD MI100 GPUs is redone and the results are compared to what presented in the published article. Upon completion of the comparison, the published results are deemed reproducible.
Retinopathy among Adult Diabetics and Its Predictors in Northwest Ethiopia
Authors: Takele Mulualem Birhan , Boneya Dube Jara , Alemu Hailemariam Abiy , Tsegaye Tesfa Birlew , Birhanu Molla Yigzaw , Alemu Simegn , Anto Tsige Gebre 
Published: February 2022

Background. Diabetic retinopathy is the leading cause of blindness among working-aged adults worldwide, including developing countries such as Ethiopia, and the burden of diabetes-related blindness is undeniably posing a massive challenge to the health care system. Diabetes and its micro- and macrovascular complications are becoming more prevalent among Ethiopian diabetics. For that reason, the purpose of this study was to assess the incidence of diabetic retinopathy and its predictors among diabetics in Ethiopia. Methods. A hospital-based retrospective cohort study was conducted using 494 randomly selected diabetics aged above 18 years at Felege Hiwot Comprehensive Specialized Hospital from 2011 through 2014 and was followed until December 2019. The preliminary and longitudinal data was abstracted into demographics, clinical, and physiological attributes using a standardized structured questionnaire. The collected data was entered into the system using EpiData version 4.2 and analyzed using STATA version 14.0. The survival experience of the patients was assessed using the Kaplan-Meier survivor function. The predictors of diabetic retinopathy were identified by the Cox proportional hazard model. Bivariable and multivariable Cox proportional hazard models were computed, and variables having a

P

value of < 0.05 in the multivariable Cox proportional hazard model were declared as significant predictors of diabetic retinopathy. Results. During the follow-up, the overall incidence rate of diabetic retinopathy was 48 per 1000 person-years (95% CI: 40.0–57.0). Age in years (AHR 1.02; 95% CI: 1.00-1.04), fasting blood sugar level (AHR 1.02; 1.00-1.04), hypertension (AHR 2.61; 95% CI: 1.47-4.63), DM patients who had

LDL
>
100

mg/dl (AHR 2.73; 95% CI: 1.32-5.64), total

cholesterol
>
200

mg/dl (AHR 2.22; 95% CI: 1.08-4.55), and positive proteinuria (AHR 1.74; 95% CI: 1.10 -2.73) were found to be the significant predictors of diabetic retinopathy. Conclusion. The overall incidence rate of diabetic retinopathy was found to be high in both type 1 and type 2 DM. Age, fasting blood sugar levels, hypertension, proteinuria, dyslipidemia, and high systolic blood pressure were all predictors of the development of diabetic retinopathy. Controlling glycemia, dyslipidemia, proteinuria, and blood pressure is critical for halting the progression of diabetic retinopathy.
Semilleros de investigación como espacio de reconocimiento de personas con altas capacidades
Authors: Gallardo Cerón Blanca Nelly , Duque-Castaño David Santiago 
Published: February 2022

(analítico)Se presentan los resultados de una investigación sobre semilleros de investigación como espacio de reconocimiento de personas con altas capacidades y talentos. Ejecutado a partir de la ruta fenomenológica y hermenéutica, utilizó como técnica la entrevista semiestructurada a cinco participantes con más de cinco años en semilleros de investigación, la cual fue interpretada a través de un análisis estructural. Se logra refigurar el concepto de semilleros de investigación y plantearlos como espacios de reconocimiento que configuran nuevas identidades y agenciamientos para la constitución de personas capaces, con apertura de sentidos hacia las posibilidades del reconocimiento mutuo y agenciamiento de nuevas prácticas en el ámbito académico, laboral y social. Las líneas de sentido son construidas por los semilleristas en contraposición a los procesos escolares; lo cual deja abierta la posibilidad de otros procesos de reconocimiento.
Palabras clave: Reconocimiento; superdotado; hermenéutica; integración social; altas capacidades; semilleros de investigación.
CYP2C19
Genotype‐Guided Antiplatelet Therapy After Percutaneous Coronary Intervention in Diverse Clinical Settings
Authors: Beitelshees Amber L. , Thomas Cameron D. , Empey Philip E. , Stouffer George A. , Angiolillo Dominick J. , Franchi Francesco , Tuteja Sony , Limdi Nita A. , Lee James C. , Duarte Julio D. , Kreutz Rolf P. , Skaar Todd C. , Coons James C. , Giri Jay , McDonough Caitrin W. , Rowland Rachel , Stevenson James M. , Thai Thuy , Vesely Mark R. , Wellen Jacob T. , Johnson Julie A. , Winterstein Almut G. , Cavallari Larisa H. , Lee Craig R. ,   Implementing Genomics in Practice (IGNITE) Network Pharmacogenetics Working Group
Published: February 2022

Background

Studies have demonstrated increased risk of major atherothrombotic events in
CYP2C19
loss‐of‐function (LOF) variant carriers versus non‐carriers treated with clopidogrel after percutaneous coronary intervention (PCI). We sought to evaluate real‐world outcomes with the clinical implementation of
CYP2C19
‐guided antiplatelet therapy after PCI.

Methods and Results

Data from 9 medical centers where genotyping was performed in the setting of PCI were included. Alternative therapy with prasugrel or ticagrelor was recommended for patients with a
CYP2C19
LOF variant. The primary outcome was the composite of major atherothrombotic events (all‐cause death, myocardial infarction, ischemic stroke, stent thrombosis, or hospitalization for unstable angina) within 12 months following PCI. Moderate or severe/life‐threatening bleeding within 12 months was a secondary outcome. Among 3342 patients, 1032 (31%) were LOF carriers, of whom 571/1032 (55%) were treated with alternative therapy. In LOF carriers, the rate of major atherothrombotic events was lower in patients treated with alternative therapy versus clopidogrel (adjusted HR, 0.56; 95% CI 0.39–0.82). In those without a LOF allele, no difference was observed (adjusted HR, 1.07; 95% CI 0.71–1.60). There was no difference in bleeding with alternative therapy versus clopidogrel in either LOF carriers or those without a LOF allele.

Conclusions

Real‐world data demonstrate lower atherothrombotic risk in
CYP2C19
LOF carriers treated with alternative therapy versus clopidogrel and similar risk in those without a LOF allele treated with clopidogrel or alternative therapy. These data suggest that PCI patients treated with clopidogrel should undergo genotyping so that
CYP2C19
LOF carriers can be identified and treated with alternative therapy.
Functional connectivity of fMRI using differential covariance predicts structural connectivity and behavioral reaction times
Authors: Chen Yusi , Bukhari Qasim , Lin Tiger W. , Sejnowski Terrence J. 
Published: February 2022

Abstract
Recordings from resting-state functional magnetic resonance imaging (rs-fMRI) reflect the influence of pathways between brain areas. A wide range of methods have been proposed to measure this functional connectivity (FC), but the lack of “ground truth” has made it difficult to systematically validate them. Most measures of FC produce connectivity estimates that are symmetrical between brain areas. Differential covariance (dCov) is an algorithm for analyzing FC with directed graph edges. When we applied dCov to rs-fMRI recordings from the human connectome project (HCP) and anesthetized mice, dCov-FC accurately identified strong cortical connections from diffusion magnetic resonance imaging (dMRI) in individual humans and viral tract tracing in mice. In addition, those HCP subjects whose dCov-FCs were more integrated, as assessed by a graph-theoretic measure, tended to have shorter reaction times in several behavioral tests. Thus, dCov-FC was able to identify anatomically verified connectivity that yielded measures of brain integration significantly correlated with behavior.
A Weak Shadow of Early Life Language Processing Persists in the Right Hemisphere of the Mature Brain
Authors: Martin Kelly C. , Seydell-Greenwald Anna , Berl Madison M. , Gaillard William D. , Turkeltaub Peter E. , Newport Elissa L. 
Published: February 2022

AbstractStudies of language organization show a striking change in cerebral dominance for language over development: We begin life with a left hemisphere (LH) bias for language processing, which is weaker than that in adults and which can be overcome if there is a LH injury. Over development this LH bias becomes stronger and can no longer be reversed. Prior work has shown that this change results from a significant reduction in the magnitude of language activation in right hemisphere (RH) regions in adults compared to children. Here we investigate whether the spatial distribution of language activation, albeit weaker in magnitude, still persists in homotopic RH regions of the mature brain. Children aged 4–13 (n = 39) and young adults (n = 14) completed an auditory sentence comprehension fMRI (functional magnetic resonance imaging) task. To equate neural activity across the hemispheres, we applied fixed cutoffs for the number of active voxels that would be included in each hemisphere for each participant. To evaluate homotopicity, we generated left-right flipped versions of each activation map, calculated spatial overlap between the LH and RH activity in frontal and temporal regions, and tested for mean differences in the spatial overlap values between the age groups. We found that, in children as well as in adults, there was indeed a spatially intact shadow of language activity in the right frontal and temporal regions homotopic to the LH language regions. After a LH stroke in adulthood, recovering early-life activation in these regions might assist in enhancing recovery of language abilities.
A Review of the Social Justice Function of Clinical Legal Education in Africa
Authors: Kotonya Anne 
Published: February 2022

Abstract
This article investigates the developments in the social justice function of clinical legal education in African countries. It is based on a systematic review conducted to provide conceptual, methodological and thematic guidance into scholarship on the utilisation of clinical legal education in African countries to meet justice needs of the indigent in society. The results are analysed and clustered into themes about scholarship on the law school, the university law clinic and challenges encountered in this endeavour. The narrative findings suggest an increased application of clinical legal education as a result of reforms in African law schools although this increase is not supported by a corresponding increase in related research and publication. The article therefore highlights gaps in knowledge and delineates a future trajectory by making suggestions for further research.
The Pagan Father for Olympias the Deaconess
Authors: Vedeshkin Mikhail A. 
Published: February 2022

Abstract
The article examines the problem of family ties of Olympias the Deaconess of Constantinople. Refuting the criticism of B. Schouler, F. Chausson, and P. Janiszewski, the author gives additional arguments in favor of the version of O. Seeck, who thought that Olympias was a daughter of the priest Seleucus, a friend of emperor Julian and Libanius. It is suggested that this Seleucus was an apostate, who had been brought up as a Christian and converted to paganism. At the same time, the author corrects Seeck’s ideas and speaks out against the traditional identification of the deaconess with the first daughter of Seleucus and his wife Alexandra, arguing that she was the second or third child of that couple.
Seeing Pains
Authors: Slater B.H. 
Published: February 2022

P.M.S. Hacker, recounting some of Wittgenstein's views, says (Hacker 1996, pl34):
[T]he pervasive conception of behaviour that has informed philosophical psychology for the last three centuries has misrepresented human behaviour as 'bare bodily movement', from which it is supposed we infer, by analogy or inference to best explanation, the inner state and so on from which the behaviour might be thought to arise ... But we see the pain in a person's face hear the glee in his chortles, perceive the affection in the looks and gestures of lovers.
In this paper I explain how this can be, before meeting several objections.
Axial and radial wood maturation in three mistletoe ‘giants’ (Loranthaceae)
Authors: Sibinelli Victor , Ceccantini Gregório 
Published: February 2022

Summary
The formation of juvenile wood featuring greater cell variation relative to mature wood is a well-known phenomenon. Once wood attains maturity, it has both more consistent cell sizes and organization. This is especially well understood for large trees used for paper and timber production, but less so for shrubs and bushes. Despite its importance, there is very little information on the wood anatomy and wood maturation available for some lineages such as the Loranthaceae (Santalales), which are mostly composed of shrubby mistletoes. Here, we studied three of the largest known mistletoe species to analyse the variation of xylem structure within both the radial and the axial axis of the stem. Using classical anatomical techniques, we determined at which point, both in thickness and in distance from the apex, these parasitic plants start producing mature wood. We measured vessel element length, fibre length, vessel diameter, and vessel density on multiple points of either very thick or very long branches of three different mistletoe species: Struthanthus rhynchophyllus, Tripodanthus acutifolius and Psittacanthus robustus. Our findings suggest that Loranthaceae mistletoes reach wood maturity rather early, with very minor differences between juvenile and mature woods. These results open new avenues for further research on the wood anatomy of mistletoe’s stems, enabling the use of smaller samples, such as those commonly present in herbarium vouchers.
The Italian Communist Party, Wars and Revolutions
Authors: Sassoon Donald 
Published: February 2022

Abstract
Following the path dependence principle, the article describes the emergence of communism and the role played by wars and revolutions as unrepeatable and extraordinary catalyst factors. According to this view, communist parties can be considered institutions that outlasted the situations that created them and that, to survive, have been constantly forced to adapt to new circumstances such as fascism, the cold war or the clash of ussr. In this framework, the article describes the peculiar path of the Italian Communist Party (pci).
Parliament v. Courts: Who has the Final Word?
Authors: Kiss Rebeka 
Published: February 2022

Abstract
Ludovika – University of Public Service, Faculty of Public Governance and International Studies organized an international online conference on 29 November 2021 on the justiciability of parliamentary procedures. As part of the conference, four presentations were given, focusing on the issue of legal remedies against parliamentary proceedings and the lack thereof. In this context, the speakers reflected on the question of whether the justiciability of parliamentary procedures is a threat to the rule of law or a necessary element of it, and on the question of how a constitutional court can become an arbitrator in political conflicts and how does it shape the constitutional concept of parliamentarism. The presentations provided a comprehensive overview of the Hungarian, Austrian, Italian, and Czech practices. The conference was moderated by Zsolt Szabó, Senior Research Fellow at the Ludovika – University of Public Service and the Editor-in-Chief of the International Journal of Parliamentary Studies.