bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural language processing applied to mental illness detection: a narrative review
Authors: Zhang Tianlin , Schoene Annika M. , Ji Shaoxiong , Ananiadou Sophia 
Published: April 2022

AbstractMental illness is highly prevalent nowadays, constituting a major cause of distress in people’s life with impact on society’s health and well-being. Mental illness is a complex multi-factorial disease associated with individual risk factors and a variety of socioeconomic, clinical associations. In order to capture these complex associations expressed in a wide variety of textual data, including social media posts, interviews, and clinical notes, natural language processing (NLP) methods demonstrate promising improvements to empower proactive mental healthcare and assist early diagnosis. We provide a narrative review of mental illness detection using NLP in the past decade, to understand methods, trends, challenges and future directions. A total of 399 studies from 10,467 records were included. The review reveals that there is an upward trend in mental illness detection NLP research. Deep learning methods receive more attention and perform better than traditional machine learning methods. We also provide some recommendations for future studies, including the development of novel detection methods, deep learning paradigms and interpretable models.
CRISPRs in the human genome are differentially expressed between malignant and normal adjacent to tumor tissue
Authors: van Riet Job , Saha Chinmoy , Strepis Nikolaos , Brouwer Rutger W. W. , Martens-Uzunova Elena S. , van de Geer Wesley S. , Swagemakers Sigrid M. A. , Stubbs Andrew , Halimi Yassir , Voogd Sanne , Tanmoy Arif Mohammad , Komor Malgorzata A. , Hoogstrate Youri , Janssen Bart , Fijneman Remond J. A. , Niknafs Yashar S. , Chinnaiyan Arul M. , van IJcken Wilfred F. J. , van der Spek Peter J. , Jenster Guido , Louwen Rogier 
Published: April 2022

AbstractClustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) have been identified in bacteria, archaea and mitochondria of plants, but not in eukaryotes. Here, we report the discovery of 12,572 putative CRISPRs randomly distributed across the human chromosomes, which we termed hCRISPRs. By using available transcriptome datasets, we demonstrate that hCRISPRs are distinctively expressed as small non-coding RNAs (sncRNAs) in cell lines and human tissues. Moreover, expression patterns thereof enabled us to distinguish normal from malignant tissues. In prostate cancer, we confirmed the differential hCRISPR expression between normal adjacent and malignant primary prostate tissue by RT-qPCR and demonstrate that the SHERLOCK and DETECTR dipstick tools are suitable to detect these sncRNAs. We anticipate that the discovery of CRISPRs in the human genome can be further exploited for diagnostic purposes in cancer and other medical conditions, which certainly will lead to the development of point-of-care tests based on the differential expression of the hCRISPRs.
The Reliability of Short Conversational Language Sample Measures in Children With and Without Developmental Language Disorder
Authors: Wilder Amy , Redmond Sean M. 
Published: April 2022

Purpose:
Language sample analysis (LSA) represents an ecologically valid method for diagnosing, identifying goals, and measuring progress in children with developmental language disorder (DLD). LSA is, however, time consuming. The purpose of this study was to determine the length of sample needed to obtain reliable LSA measures for children in kindergarten and first grade with typical language (TL) and DLD using automated analyses from the Systematic Analysis of Language Transcripts software.

Method:

Play-based conversational language samples collected on kindergarten to first-grade children with TL (
n
= 21) and DLD (
n
= 21) from a community-based sample were analyzed. Eight LSA measures were calculated from 1-, 3-, 5-, 7-, and 10-min sample cuts and compared to 20-min samples for reliability.

Results:
Reliability estimates were similar for the TL and DLD groups except for errors and omissions, which showed overall higher levels of reliability in the DLD group and reached acceptable levels at 3 min. Percent grammatical utterances were reliable at 7 min in the DLD group and not reliable in shorter samples in the TL group. The subordination index was reliable at 10 min for both groups. Number of different words reached acceptable reliability at the 3-min length for the DLD group and at the 10-min length for the TL group. Utterances and words per minute were reliable at 3 min and mean length of utterance at 7 min in both groups.

Conclusions:
Speech-language pathologists can obtain reliable LSA measures from shorter, 7-min conversational language samples from kindergarten to first-grade children with DLD. Shorter language samples may encourage increased use of LSA.

Supplemental Material:

https://doi.org/10.23641/asha.19529287
Transient analysis of dynamically switched frequency shift keyed transmitters
Authors: Srivastava Shruti , Adams Jacob J. 
Published: April 2022

AbstractA dynamically switched matching network for transmitting a wideband frequency shift keyed (FSK) signal from an electrically small monopole antenna is studied. The effects of switch synchronization, frequency deviation, the antenna's impedance, and Q‐factor at the two carrier frequencies are studied. It is found that the average energy per bit of the transmitted FSK waveform is maximum when the loss of reactive energy between states transition is minimised by switching it at the instant of peak voltage across the antenna's terminals. However, a switching network topology that stores more energy is shown to be less sensitive to the synchronization condition. In addition, we show that this dynamically switched system transmits more bit energy when the carriers are closely spaced due to a smaller change in stored energy levels between states. Results are presented using a detailed analytical study and full wave simulation. Near field measurements from a monopole antenna circuit model show that under proper conditions, an FSK signal can be transmitted at a rate 7 times greater than the bandwidth of the transmit antenna with minimal signal quality degradation.
Disrupted myelination network in the cingulate cortex of Parkinson's disease
Authors: Xie Song , Yang Jiajun , Huang Shenghui , Fan Yuanlan , Xu Tao , He Jiangshuang , Guo Jiahao , Ji Xiang , Wang Zhibo , Li Peijun , Chen Jiangfan , Zhang Yi 
Published: April 2022

AbstractThe cingulate cortex is part of the conserved limbic system, which is considered as a hub of emotional and cognitive control. Accumulating evidence suggested that involvement of the cingulate cortex is significant for cognitive impairment of Parkinson's disease (PD). However, mechanistic studies of the cingulate cortex in PD pathogenesis are limited. Here, transcriptomic and regulatory network analyses were conducted for the cingulate cortex in PD. Enrichment and clustering analyses showed that genes involved in regulation of membrane potential and glutamate receptor signalling pathway were upregulated. Importantly, myelin genes and the oligodendrocyte development pathways were markedly downregulated, indicating disrupted myelination in PD cingulate cortex. Cell‐type‐specific signatures revealed that myelinating oligodendrocytes were the major cell type damaged in the PD cingulate cortex. Furthermore, downregulation of myelination pathways in the cingulate cortex were shared and validated in another independent RNAseq cohort of dementia with Lewy bodies (DLB). In combination with ATACseq data, gene regulatory networks (GRNs) were further constructed for 32 transcription factors (TFs) and 466 target genes among differentially expressed genes (DEGs) using a tree‐based machine learning algorithm. Several transcription factors, including Olig2, Sox8, Sox10, E2F1, and NKX6‐2, were highlighted as key nodes in a sub‐network, which control many overlapping downstream targets associated with myelin formation and gliogenesis. In addition, the authors have validated a subset of DEGs by qPCRs in two PD mouse models. Notably, seven of these genes,TOX3, NECAB2 NOS1, CAPN3, NR4A2, E2F1 and FOXP2, have been implicated previously in PD or neurodegeneration and are worthy of further studies as novel candidate genes. Together, our findings provide new insights into the role of remyelination as a promising new approach to treat PD after demyelination.
Hanle rotation signatures in Sr I 4607 Å
Authors: Zeuner F. , Belluzzi L. , Guerreiro N. , Ramelli R. , Bianda M. 
Published: April 2022

Context.Measuring small-scale magnetic fields and constraining their role in energy transport and dynamics in the solar atmosphere are crucial, albeit challenging, tasks in solar physics. To this aim, observations of scattering polarization and the Hanle effect in various spectral lines are increasingly used to complement traditional magnetic field determination techniques.Aims.One of the strongest scattering polarization signals in the photosphere is measured in the Sr Iline at 4607.3 Å when observed close to the solar limb. Here, we present the first observational evidence of Hanle rotation in the linearly polarized spectrum of this line at several limb distances.Methods.We used the Zurich IMaging POLarimeter, ZIMPOL at the IRSOL observatory, with exceptionally good seeing conditions and long integration times. We combined the fast-modulating polarimeter with a slow modulator installed in front of the telescope. This combination allows for a high level of precision and unprecedented accuracy in the measurement of spectropolarimetric data.Results.Fixing the reference direction for positive StokesQparallel to the limb, we detected singly peakedU/Isignals well above the noise level. We can exclude any instrumental origins for suchU/Isignals. These signatures are exclusively found in the Sr Iline, but not in the adjoining Fe Iline, therefore eliminating the Zeeman effect as the mechanism responsible for their appearance. However, we find a clear spatial correlation between the circular polarization produced by the Zeeman effect and theU/Iamplitudes. This suggests that the detectedU/Isignals are the signatures of Hanle rotation caused by a spatially resolved magnetic field.Conclusions.A novel measurement technique allows for determining the absolute level of polarization with unprecedented precision. Using this technique, high-precision spectropolarimetric observations reveal, for the first time, unambiguousU/Isignals attributed to Hanle rotation in the Sr Iline.
Refinement of the convex shape model and tumbling spin state of (99942) Apophis using the 2020–2021 apparition data
Authors: Lee H.-J. , Kim M.-J. , Marciniak A. , Kim D.-H. , Moon H.-K. , Choi Y.-J. , Zoła S. , Chatelain J. , Lister T. A. , Gomez E. , Greenstreet S. , Pál A. , Szakáts R. , Erasmus N. , Lees R. , Janse van Rensburg P. , Ogłoza W. , Dróżdż M. , Żejmo M. , Kamiński K. , Kamińska M. K. , Duffard R. , Roh D.-G. , Yim H.-S. , Kim T. , Mottola S. , Yoshida F. , Reichart D. E. , Sonbas E. , Caton D. B. , Kaplan M. , Erece O. , Yang H. 
Published: April 2022

Context. The close approach of the near-Earth asteroid (99942) Apophis to Earth in 2029 will provide a unique opportunity to examine how the physical properties of the asteroid could be changed due to the Earth’s gravitational perturbation. As a result, the Republic of Korea is planning a rendezvous mission to Apophis.
Aims. Our aim was to use photometric data from the apparitions in 2020−2021 to refine the shape model and spin state of Apophis.
Methods. Using thirty-six 1- to 2-meter-class ground-based telescopes and the Transiting Exoplanet Survey Satellite, we carried out a photometric observation campaign throughout the 2020−2021 apparition. The convex shape model and spin state were refined using the light-curve inversion method.
Results. According to our best-fit model, Apophis is rotating in a short-axis mode with rotation and precession periods of 264.178 h and 27.38547 h, respectively. The angular momentum vector orientation of Apophis was found to be (275°, −85°) in the ecliptic coordinate system. The ratio of the dynamic moments of inertia of this asteroid was fitted to Ia : Ib : Ic = 0.64 : 0.97 : 1, which corresponds to an elongated prolate ellipsoid. These findings regarding the spin state and shape model can be used to both design the space mission scenario and investigate the impact of the Earth’s tidal force during close encounters.
2D phononic-crystal Luneburg lens for all-angle underwater sound localization
Authors: Ruan Yongdu , Liang Xu 
Published: April 2022

Phononic crystals are well known for acoustic wave manipulation which may have potential application in an underwater acoustic detection system. In this work, we design and simulate a two-dimensional Luneburg lens based on gradient-index (GRIN) phononic crystal that is composed of PLA-Air inclusion, and a novel application of GRIN phononic crystals is proposed to sound localization. The Luneburg lens has a broadband working range, from 1500 Hz to 7500 Hz, for acoustic wave focusing with sensitive directivity and signal-to-noise improvement. By searching maximum wave intensity’s position of the focusing beam, the propagating direction of an unknown sound wave can be directly recognized covering 360°. Besides, we redesign the conventional square-lattice Luneburg lenses using annular lattices for better performance. The annular-lattice Luneburg lens overcomes the weakness of configuration defect due to the square lattice. The numerical results show that the redesign Luneburg lenses have high accuracy for distance measurement from 5 m to 35 m through the triangulation location. In a word, this work tries to explore a novel application of phononic crystals in underwater acoustic positioning and navigation technology.
Evaluation and Treatment of Severe Hyperacusis
Authors: Valente Michael , Goebel Joel , Duddy Diane , Sinks Belinda , Peterein Judy 
Published: April 2022

AbstractA 52-year-old male was evaluated by the authors after initially reporting fullness in his left ear while traveling on an airplane. A unique feature of the patient's complaint was the development of severe bilateral hyperacusis (loudness discomfort levels of between 20–34 dB HL) in spite of the fact that the hearing loss was initially reported in the left ear. To achieve loudness comfort, the patient was initially fit with ER-25 musician earplugs that proved to be unsuccessful. The patient next purchased earplugs and earmuffs from a gun shop in order to obtain relief from the pain and discomfort caused by his exposure to everyday environmental sounds. This paper describes the use of hearing devices that proved to be effective in providing attenuation sufficient that the patient rarely needs to rely on earplugs and ear-muffs for relief from his hyperacusis.
Abbreviations: CBC = complete blood count, ESR = erythrocyte sedimentation rate, LDL= loudness discomfort level
Adaptation to Loudness and Environmental Stimuli in Three Newly Fitted Hearing Aid Users
Authors: Lindley George A. , Palmer Catherine V. , Durrant John , Pratt Sheila 
Published: April 2022

AbstractHearing aid fitting strategies can be categorized according to whether a loudness normalization or a loudness equalization rationale is employed. Regardless of the underlying rationale, the amount of patient participation in determining the initial hearing aid settings will vary when an audiologist-driven (AD) versus a patient-driven protocol is employed. When an AD protocol is used, few changes are made during the initial fitting session based on user feedback. It is assumed that the patient will adapt to the loudness and/or sound quality provided by the hearing aids if not immediately acceptable. The following three case reports document varying degrees of adaptation to hearing aid settings derived using an AD approach. Clinical implications will be discussed.
Abbreviations: AD = audiologist driven, DSL [i/o] = Desired Sensation Level input/output, EN = environmental noise subscale, HINT = Hearing in Noise Test, IHAFF = Independent Hearing Aid Fitting Forum, LE = loudness equalization, LN = loudness normalization, PD = patient driven, PHAP = Profile of Hearing Aid Performance, RAB = Ricketts and Bentier, SII = Speech Intelligibility Index, WDRC = wide dynamic range compression
Cisplatin Ototoxicity, Increased DPOAE Amplitudes, and Magnesium Deficiency
Authors: Cevette Michael J. , Drew Danielle , Webb Teresa M. , Marion Mitchell S. 
Published: April 2022

AbstractOuter hair cell (OHC) metabolism is blocked by cisplatin. Concurrent changes in the renal handling of magnesium occur because of the damage cisplatin causes to the renal proximal tubule cells within the thick ascending loop of Henle. Although there is no evidence of cisplatin within the OHCs, there are significant levels of intracellular calcium, the antagonist to magnesium at the cell membrane. The OHC motile response is dependent on intracellular calcium. When the calcium current is suppressed by an antagonist, the extracellular OHC microphonic potential decreases. Magnesium deficiency is known to produce hyperexcitabililty within the central nervous system, including fatal audiogenic seizures. In addition, increases in the amplitude of the auditory brainstem response wave V occur with aminoglycoside therapy and magnesium deficiency. This paper illustrates the amplitude growth of distortion product otoacoustic emissions in two patients treated with cisplatin and explores the possible underlying reasons why this may be related to magnesium metabolism.
Abbreviations: DPOAEs = distortion product otoacoustic emissions, OAEs = otoacoustic emissions, OHC = outer hair cell, TEOAEs = transient otoacoustic emissions
A relational view on the performance effects of international diversification strategies
Authors: Yildiz H. Emre , Morgulis-Yakushev Sergey , Holm Ulf , Eriksson Mikael 
Published: April 2022

AbstractInternational diversification is a fundamental pillar of multinational corporations’ (MNCs) growth strategies. Consequently, there is a considerable body of research on the performance implications of MNCs’ international diversification strategies. We extend this literature by adopting a relational view where we compare the diversification profiles of firms in an inter-organizational context. We argue that the relative characteristics of firms’ and their partners’ diversification profiles is an indicator of parties’ resource bases and thereby can explain if and when inter-organizational ties yield optimum performance outcomes. We examine these relative characteristics and propose a conceptual refinement by differentiating between the degree and content dimensions of international diversification. Analyzing data from 202 manufacturing firms from the S&P 500 list, we find that firms achieve optimum performance when their partners have moderately higher degrees of international diversification and a moderate overlap of presence in foreign markets.
20th Century revolutions: characteristics, types, and waves
Authors: Grinin Leonid , Grinin Anton , Korotayev Andrey 
Published: April 2022

AbstractThe 20th century revolutionary process had a big impact on the World System and significantly changed its entire configuration. However, there are essential gaps in terms of theoretical approaches, in particular, in terms of the typology of revolutions. Moreover, there is clearly insufficient research related to qualitative and quantitative analysis and consideration of the revolutions of the 20th century in their entirety. This article aims to fill those gaps by pursuing three main goals: (1) comparison of revolutions of the 20th and 19th centuries, highlighting the important characteristics of the former; (2) classification of revolutions of the 20th century; (3) identification of the main revolutionary waves of the 20th century and their essential characteristics.
Challenges in large-scale bioinformatics projects
Authors: Morrison-Smith Sarah , Boucher Christina , Sarcevic Aleksandra , Noyes Noelle , O’Brien Catherine , Cuadros Nazaret , Ruiz Jaime 
Published: April 2022

AbstractBiological and biomedical research is increasingly conducted in large, interdisciplinary collaborations to address problems with significant societal impact, such as reducing antibiotic resistance, identifying disease sub-types, and identifying genes that control for drought tolerance in plants. Many of these projects are data driven and involve the collection and analysis of biological data at a large-scale. As a result, life-science projects, which are frequently diverse, large and geographically dispersed, have created unique challenges for collaboration and training. We examine the communication and collaboration challenges in multidisciplinary research through an interview study with 20 life-science researchers. Our results show that both the inclusion of multiple disciplines and differences in work culture influence collaboration in life science. Using these results, we discuss opportunities and implications for designing solutions to better support collaborative tasks and workflows of life scientists. In particular, we show that life science research is increasingly conducted in large, multi-institutional collaborations, and these large groups rely on “mutual respect” and collaboration. However, we found that the interdisciplinary nature of these projects cause technical language barriers and differences in methodology affect trust. We use these findings to guide our recommendations for technology to support life science. We also present recommendations for life science research training programs and note the necessity for incorporating training in project management, multiple language, and discipline culture.
Double crossing conical intersections and anti-Vavilov fluorescence in tetraphenyl ethylene
Authors: Hou Zhuowei , Guan Jianxin , Peng Jie , Li Xinmao , Yu Zhihao , Zheng Junrong 
Published: April 2022

Conical intersections (CIs) provide effective fast nonradiative decay pathways for electronic excitation, which can significantly influence molecular photoluminescence properties. However, in many cases, crossing a CI does not have direct observables, making studies of CIs experimentally challenging. Herein, the theoretically predicted double CIs by cis–trans twisting and cyclization in tetraphenyl ethylene, a well-known aggregation-induced emission molecule, are investigated with excitation dependent ultrafast UV/IR spectroscopy and fluorescence. Both the fluorescence quantum yield and the efficiency of cyclization are found to be smaller with a shorter excitation wavelength. An abrupt change occurs at about 300–310 nm. The results imply that crossing the twisting CI has a larger barrier than the cyclization CI, and the cis–trans twisting motion is probably involved with large solvation reorganization.