bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Experiences of High-Performance Female Coaches in Luxembourg
Authors: Poos Laura , Carson Fraser 
Published: March 2022

Recent literature has noted the underrepresentation of women in high-performance (HP) coaching and the challenges faced when they do succeed in gaining entry to this male-dominated domain. Initiatives have been implemented in developed sporting nations to address this. However, less is known regarding the experience of women coaching at HP level in small, economically advanced countries and metropolises, where a number of additional sociocultural barriers exist. Underpinned by LaVoi and Dutove’s ecological model, six women currently coaching at HP level in the Grand Duchy of Luxembourg were interviewed, reflecting on their experiences in their role. A social phenomenological analysis approach was taken, with a deductive thematic analysis identifying 32 raw data themes: five supports (e.g., passion for the job) and four barriers (e.g., personal sacrifices) were reported at individual level; five supports (e.g., family support) and three barriers (e.g., lack of federation support) identified at interpersonal level; three supports (e.g., open communication environment) and seven barriers (e.g., lack of entry opportunities) noted at organizational level; and two supports (e.g., increased acceptance by male athletes) and three barriers (e.g., hegemonic masculinity) described at societal level. Further challenges exist in Luxembourg due to coaching not being seen as a legitimate career pathway and an underlying cultural expectation for women to manage domestic duties. The structure of the coach education system in Luxembourg makes it possible to address these barriers and enable a more diverse workforce in leadership positions in HP sport. Doing so should create more opportunities and support for women in coaching.
Benzene exposure and risk of benzene poisoning in Chinese workers
Authors: Vermeulen Roel , Portengen Lützen , Li Guilan , Gilbert Ethel S , Dores Graça M , Ji Bu-Tian , Hayes Richard , Yin Sognian , Rothman Nathaniel , Linet Martha S , Lan Qing 
Published: March 2022

ObjectivesBenzene is a known haematoxin and leukemogen that can cause benzene poisoning (BP), that is, a persistent reduction in white cell counts that is strongly associated with increased risk of lymphohaematopoietic malignancies. Data are needed on the exposure–response, particularly at low doses and susceptible populations for clinical and regulatory purposes.MethodsIn a case-cohort study among 110 631 Chinese workers first employed 1949–1987 and followed up during 1972–1999, we evaluated BP risk according to benzene exposure level and investigated risk modification by subject (sex, attained age) and exposure-related factors (latency, exposure windows, age at first benzene exposure, coexposure to toluene) using excess relative risk and excess absolute risk models.ResultsThere were 538 BP cases and 909 benzene-exposed referents. The exposure metric with best model fit was cumulative benzene exposure during a 5-year risk window, followed by a 9-month lag period before BP diagnosis. Estimated excess absolute risk of BP at age 60 increased from 0.5% for subjects in the lowest benzene exposure category (>0 to 10 ppm-years) to 5.0% for those in the highest category (>100 ppm-years) compared with unexposed subjects. Increased risks were apparent at low cumulative exposure levels and for workers who were first exposed at <30 years of age.ConclusionsOur data show a clear association between benzene exposure and BP, beginning at low cumulative benzene exposure levels with no threshold, and with higher risks for workers exposed at younger ages. These findings are important because BP has been linked to a strongly increased development of lymphohaematopoietic malignancies.
Structural and geochronological constraints on orogenic gold mineralization in the western Wabigoon subprovince, Canada
Authors: Zammit K. , Perrouty S. , Frieman B.M. , Marsh J.H. , Holt K.A. 
Published: March 2022

Some of the world’s largest orogenic gold deposits are hosted within granite-greenstone subprovinces of the Superior Province of Canada. The known gold endowment of the western Wabigoon subprovince is much less than that of the Abitibi subprovince, despite both Neoarchean subprovinces sharing similar structural and metallogenic histories. Further, the relationship between regional deformation and orogenic gold mineralizing events in the western Wabigoon subprovince is poorly constrained in comparison with other greenstone belts within the Superior Province. New structural mapping of the Dryden area of the western Wabigoon subprovince indicates that it experienced a N–S shortening event (D1), circa 2705–2695 Ma, which reactivated, or initiated the formation of, the E–W-trending Wabigoon and Mosher Bay – Washeibemaga deformation zones (Wdz and MBWdz, respectively). Following the D1 event, after 2695 Ma, a protracted period of NNW–SSE shortening (D2) localized transpression along the Manitou Dinorwic deformation zone (MDdz), which is spatially associated with orogenic gold systems, including the Goldlund deposit (∼1.7 Moz Au) and Kenwest prospect (∼0.3 Moz Au). During D2, the MDdz experienced NW-over-SE sinistral transpression, while the Wdz and MBWdz experienced N-over-S dextral-sense movement. U–Pb geochronology of vein-hosted xenotime from the Goldlund deposit and Kenwest prospect indicate that the main hydrothermal event, and likely gold mineralization, occurred syn- to late-D2 deformation around 2664 ± 8.3 Ma. A second population of xenotime, and overgrowths, recorded a younger hydrothermal overprint between ∼2590 and ∼2580 Ma. These ages are comparable with other absolute geochronology data on hydrothermal events in the gold-rich Abitibi subprovince. The structural evolution and timing of orogenic hydrothermal events in the western Wabigoon subprovince are broadly similar to the Abitibi subprovince. Therefore, we propose that the structural evolution and timing of individual greenstone belts is not the primary controlling factor on their bulk gold endowment. Nevertheless, orogenic gold deposits are spatially associated with major D2 deformation zones and linked to widespread hydrothermal event(s), spanning 2680–2660 Ma across the southern Superior Province.
On well-posedness and algebraic type of the five-dimensional charged rotating black hole with two equal-magnitude angular momenta
Authors: Fröb Markus B. , Khavkine Igor , Málek Tomáš , Pravda Vojtěch 
Published: March 2022

AbstractWe study various mathematical aspects of the charged rotating black hole with two equal-magnitude angular momenta in five dimensions. We introduce a coordinate system that is regular on the horizon and in which Einstein–Maxwell equations reduce to an autonomous system of ODEs. Employing Bondi and Kruskal-like coordinates, we analyze the geometric regularity of the black hole metric at infinity and the horizon, respectively, and the well-posedness of the corresponding boundary value problem. We also study the algebraic types of the electromagnetic and curvature tensors. While outside the horizon the electromagnetic and Ricci tensors are of type D, the Weyl tensor is algebraically general. The Weyl tensor simplifies to type II on the horizon and type D on the bifurcation sphere. These results imply inconsistency of the metric with the Kerr–Schild form with a geodesic Kerr–Schild vector. This feature is shared by the four-dimensional Kerr–Newman metric and the vacuum Myers–Perry or charged Schwarzschild–Tangherlini geometries in arbitrary dimension, but hence not by the black hole we have considered here.
Inhibiting ERK5 Overcomes Breast Cancer Resistance to Anti-HER2 Therapy By Targeting the G1–S Cell-Cycle Transition
Authors: Zhang Jingwei , Pearson Adam J. , Sabherwal Nitin , Telfer Brian A. , Ali Nisha , Kan Karmern , Xu Qiuping , Zhang Wei , Chen Fuhui , Li Shiyang , Wang Jinhua , Gray Nathanael S. , Risa-Ebrí Blanca , Finegan Katherine G. , Cross Michael J. , Giurisato Emanuele , Whitmarsh Alan J. , Tournier Cathy 
Published: March 2022

Targeting HER2 has become a landmark in the treatment of HER2-driven breast cancer. Nonetheless, the clinical efficacy of anti-HER2 therapies can be short-lived and a significant proportion of patients ultimately develop metastatic disease and die. One striking consequence of oncogenic activation of HER2 in breast cancer cells is the constitutive activation of the extracellular-regulated protein kinase 5 (ERK5) through its hyperphosphorylation. In this study, we sought to decipher the significance of this unique molecular signature in promoting therapeutic resistance to anti-HER2 agents. We found that a small-molecule inhibitor of ERK5 suppressed the phosphorylation of the retinoblastoma protein (RB) in HER2-positive breast cancer cells. As a result, ERK5 inhibition enhanced the antiproliferative activity of single-agent anti-HER2 therapy in resistant breast cancer cell lines by causing a G1 cell-cycle arrest. Moreover, ERK5 knockdown restored the antitumor activity of the anti-HER2 agent lapatinib in human breast cancer xenografts. Taken together, these findings support the therapeutic potential of ERK5 inhibitors to improve the clinical benefit that patients receive from targeted HER2 therapies.Significance:Here we demonstrate that targeting ERK5 in HER2-positive breast cancer cells reduces the level of phosphorylation of RB, an important mediator of the G1–S transition. This effect is associated with increased antitumor activity of lapatinib in combination therapy with ERK5 silencing. Collectively, these findings reveal that ERK5 constitutes a relevant therapeutic target for the many patients with resistant HER2-positive breast cancer.
Advisory Proceedings before the Seabed Disputes Chamber and before the ITLOS as a Full Court
Authors: Kateka James L. 
Published: March 2022

Advisory Opinions are of interest as they have the potential to develop law. The Seabed Disputes Chamber possesses such competence and has already used it.
According to article 138 of its Rules the International Tribunal for the Law of the Sea has such an advisory competence and – since the beginning of 2013 – it is faced with a request for an Advisory Opinion. It will have to deal with the admissibility of this Advisory Opinion in abstracto as well as in concreto and thus shed some light on the legal parameters for such an exercise of jurisdiction.
Seasonal changes in the width and structure of non-collapsed phloem affect the assessment of its potential conducting efficiency
Authors: Gričar Jožica , Prislan Peter 
Published: March 2022

Summary
Quantitative phloem anatomy is increasingly used in dendroecological studies since recent evidence shows that phloem traits are a valuable indicator of the morphological and physiological strategies of tree performance in different environments. To better understand intra-annual variations in non-collapsed phloem (NCPH) width and structure in three temperate species (Picea abies, Fagus sylvatica, and Quercus petraea), we investigated phloem samples repeatedly taken during the growing season, using light microscopy. The diameter and area of sieve elements were measured in early and late phloem to estimate their conducting potential. The seasonal dynamics of phloem formation and the collapse of sieve elements significantly affect the structure and width of the NCPH. In combination with sieve element characteristics, they determine the conducting potential of the NCPH, which is not constant throughout the growing season. Although the three species differed in terms of wood porosity, the seasonal structural variations of the NCPH followed a similar pattern. At the onset of the growing season, the phloem increment of the previous year was crucial for the function and accounted for over 80% of the NCPH, whereas at the end of the growing season, the phloem increment of the current year constituted the majority of the NCPH. These results indicate that sampling time should be considered when comparing quantitative phloem anatomy data from different laboratories, indicating the need for a uniform sampling protocol and methodology. Otherwise, the assessment of the conducting potential of phloem sieve elements is difficult to compare.
Zosimos and Theosebeia
Authors: Grimes Shannon 
Published: March 2022

Abstract
This paper fleshes out the relationship of the third-century alchemist Zosimos of Panopolis and his colleague, Theosebeia, which was later dramatized in the Book of Pictures, an illustrated Arabic manuscript (thirteenth century) that depicts the couple crowned with the sun and moon, representing various alchemical processes. Their relationship provides an important window into the historical development of erotic themes in alchemical literature. I argue that there is an erotics of pedagogy at work in this text, rooted in alchemical allegories of the fusion of male and female substances and Islamic notions of the initiatory relationship between teacher and student.
The Cosmological Gnosis of Miguel Serrano
Authors: Versluis Arthur 
Published: March 2022

Abstract
A close look at a very unusual instance of how gnosis, and specific concepts from early Christian-era Gnosticism, appear directly in the numerous late works of a recent Chilean author, Miguel Serrano (1917–2009), and of how his work and thought exemplifies cosmological gnosis. Many international readers knew Serrano as author of unusual fictional works, and as an ambassador for Chile to several countries. During his time abroad, he met, and in many cases befriended, famous figures of the day, including Carl Jung, Herman Hesse, Ezra Pound and the fourteenth Dalai Lama. But fewer are aware of his works promoting a grand cosmological synthesis of many world religious traditions with esoteric Hitlerism expressed in gnostic terms. His syncretic system includes references to a demiurge and to gnosis, as well as to many other esoteric traditions from Europe, India, Tibet, and elsewhere, largely in a Gnostic context. This article by Arthur Versluis is the first to explore this aspect of Serrano’s work.
Magic in the Ancient Greco-Roman and Ancient Jewish Worlds
Authors: Davila James R. 
Published: March 2022

Abstract
In Drawing Down the Moon: Magic in the Ancient Greco-Roman World, Radcliffe Edmonds provides us with a new etic framework for understanding ancient magic, but one steeped in the emic perspectives of the actual practitioners and clients as preserved in the literary, epigraphic, and archaeological evidence. In this paper I examine Edmonds’s findings in relation to the ancient Jewish magical and mystical traditions found mainly in Sefer HaRazim, “The Book of the Mysteries,” a late-antique ritual handbook written in Hebrew.
The Role of Atlantic Basin Geometry in Meridional Overturning Circulation
Authors: Ragen Sarah , Armour Kyle C. , Thompson LuAnne , Shao Andrew , Darr David 
Published: March 2022

Abstract
We present idealized simulations to explore how the shape of eastern and western continental boundaries along the Atlantic Ocean influences the Atlantic meridional overturning circulation (AMOC). We use a state-of-the art ocean–sea ice model (MOM6 and SIS2) with idealized, zonally symmetric surface forcing and a range of idealized continental configurations with a large, Pacific-like basin and a small, Atlantic-like basin. We perform simulations with five coastline geometries along the Atlantic-like basin that range from coastlines that are straight to coastlines that are shaped like the coasts of the American and African continents. Changing the Atlantic basin coastline shape influences AMOC strength in a manner distinct from simply increasing basin width: widening the basin while maintaining straight coastlines leads to a 10-Sv (1 Sv ≡ 106 m3 s−1) increase in AMOC strength, whereas widening the basin with the geometry of the American and African continents leads to a 6-Sv increase in AMOC strength, despite both cases representing the same average basin-width increase relative to a control case. The structure of AMOC changes are different between these two cases as well: a more realistic basin geometry results in a shoaled AMOC while widening the basin with straight boundaries deepens AMOC. We test the influence of the shape of the both boundaries independently and find that AMOC is more sensitive to the American coastline while the African coastline impacts the abyssal circulation. We also find that AMOC strength and depth scales well with basin-scale meridional density difference, even with different Atlantic basin geometries, illuminating a robust physical link between AMOC and the North Atlantic western boundary density gradient.
Insecticidal and growth inhibitory activity of gut microbes isolated from adults of Spodoptera litura (Fab.)
Authors: Devi Sarita , Saini Harvinder Singh , Kaur Sanehdeep 
Published: March 2022

Abstract
Background
Spodoptera litura (Fab.) (Lepidoptera: Noctuidae) commonly known as tobacco caterpillar is a polyphagous pest that causes significant damage to many agricultural crops. The extensive use of chemical insecticides against S. litura has resulted in development of resistance. In order to find potential biocontrol agents, gut microbes were investigated for insecticidal potential. These microbes live in a diverse relationship with insects that may vary from beneficial to pathogenic.

Results
Enterococcus casseliflavus, Enterococcus mundtii, Serratia marcescens, Klebsiella pneumoniae, Pseudomonas paralactis and Pantoea brenneri were isolated from adults of S. litura. Screening of these microbial isolates for insecticidal potential against S. litura showed higher larval mortality due to K. pneumoniae and P. paralactis. These bacteria also negatively affected the development of insect along with significant decline in relative growth and consumption rate as well as efficiency of conversion of ingested and digested food of insect. The bacteria significantly decreased the reproductive potential of insect. Perturbations in the composition of gut microbiome and damage to gut epithelium were also observed that might be associated with decreased survival of this insect.

Conclusions
Our study reveals the toxic effects of K. pneumoniae and P. paralactis on biology of S. litura. These bacteria may be used as potential candidates for developing ecofriendly strategies to manage this insect pest.
An insight into patients’ perspectives on barriers affecting participation in shared decision making among patients with diabetes mellitus in Malawi
Authors: Makwero Martha , Muula Adamson S. , Anyanwu Felix Chima , Igumbor Jude 
Published: March 2022

AbstractBackgroundPatient participation in decision making is a basic tenet for a patient centred care experience and, has potential to improve care experiences and responsiveness in chronic diseases such as Diabetes Mellitus (DM). However, documented experiences show that patient participation in decisions making is wanting. As Malawi strives to institutionalise patient centred care delivery, it is important to examine patients’ experiences and perceptions to identify barriers affecting their participation in shared decision making because this may provide evidence supporting strategies in implementation of the institutionalisation.AimThe study sought to describe perspectives about barriers to participation in shared decision making among patients with DM in Malawi.MethodsThis was an exploratory qualitative study. We targeted patients attending DM clinics in four public health facilities in southern Malawi from September to December 2019. We used In-Depth Interviews and Focus Group Discussions. Data was managed using Nvivo version 11 software and analysed using Content Analysis.ResultsThe study highlights the values, perceptions and benefits of shared decision making. Furthermore, patients’ narratives expose the struggles and vulnerabilities in their attempts to engage their providers towards shared decision making.ConclusionInteractional power imbalances, insufficient dialogue and patients’ own restrictive attitudes towards engagement with their providers thwarts SDM in clinical encounters. To make SDM a reality, transforming medical education that emphasizes on the value of good patient-provider relationship and providers’ attitudes to regard patients as active partners may be a good starting point. Additionally, strategies that empower and change patients’ perceptions about SDM require investment.
Undifferentiated high-grade pleomorphic sarcoma of the colon: a rare case report and literature review
Authors: Han Xu , Zhao Linxian , Mu Yu , Liu Guoliang , Zhao Guohong , He Hongyu , Wang Shu , Li Jiannan 
Published: March 2022

Abstract
Background
Undifferentiated pleomorphic sarcoma (UPS), also known as malignant fibrous histiocytoma (MFH), hardly originates from the colorectum.

Case presentation
We reported a 65-year-old female presented with UPS in the descending colon. Computed tomography (CT) revealed an irregularly thickened descending colon. On colonoscopy examination, an ulcerative tumour was identified. The patient received radical resection of the left colon and partial enterectomy. The resected tumor was ulcerative, 10 cm × 8 cm × 5 cm in size, and infiltrated the serosa layer. Postsurgical pathology showed that the tumor was high-graded UPS in the colon with large amounts of necrotic tissues.

Conclusions
UPS in the large intestine is a rare malignant tumor with a poor prognosis and unknown pathogenesis. The main treatment for UPS is early complete resection. Postsurgery adjuvant radiotherapy or chemotherapy can be attempted.