bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intergenerational living and learning: The value and risks of co‐locating retirement villages on secondary school campuses – Evaluating the GrandSchools vision
Authors: Trotter Mark , Sanders Paul , Lindquist Marissa , Miller Evonne , Hajirasouli Aso , Blake Andrea , Harrington Rosamund , Olsen Heidi , Tyvimaa Tanja , Pepping Gert‐Jan , Kuys Suzanne , Drogemuller Robin 
Published: July 2022

AbstractObjectivesGrandSchools is a new concept which co‐locates retirement villages with secondary schools in one physical environment. Designed to enhance the health and well‐being of both younger and older generations, this intergenerational‐shared campus model promotes intergenerational inclusivity and active learning and living. In this paper, we explore stakeholder experts' perceptions of current opportunities and impediments to this proposed intergenerational learning and living model.MethodsA qualitative study reporting on findings from an industry seminar (n = 50) and key interviews (n = 10) from stakeholders in education, health, higher education, the management and operation of retirement villages, and design firms.ResultsThree key themes summarised participants' assessment of the value, risks and what needs to change in order for intergenerational living and learning to become a reality.ConclusionsBy bringing younger and older generations together in one shared campus location, GrandSchools is a novel idea to promote intergenerational inclusivity, enhancing the health and well‐being of our whole community.
Gifts, Unwanted and Ungiven
Authors: Wulff Helena 
Published: July 2022

SUMMARY
Against a backdrop of gift‐giving and reciprocity as keys in building and confirming social relationships in the field, this fictional narrative reveals a string of gift‐giving events that did not work out. This outcome is rarely reported on in anthropology, but here one gift was returned immediately, another promised but never produced. There is also the anti‐climactic nature of a parting gift when it is time for the fieldworker to exit the field. The setting is Dublin’s literary world, and the fieldwork includes a number of appreciated gifts, though not always in the form of an equal exchange of objects. The occurrence of unwanted and ungiven gifts that recur through the narrative are thorny reminders of the fragility of friendship in the field. The characters in the narrative are composite except for cameo appearances of named writers.
Flexible Bayesian modelling in dichotomous item response theory using mixtures of skewed item curves
Authors: Gonçalves Flávio B. , Venturelli S. L. Juliane , Loschi Rosangela H. 
Published: July 2022

AbstractMost item response theory (IRT) models for dichotomous responses are based on probit or logit link functions which assume a symmetric relationship between the probability of a correct response and the latent traits of individuals taking a test. This assumption restricts the use of those models to the case in which all items behave symmetrically. On the other hand, asymmetric models proposed in the literature impose that all the items in a test behave asymmetrically. This assumption is inappropriate for great majority of tests which are, in general, composed of both symmetric and asymmetric items. Furthermore, a straightforward extension of the existing models in the literature would require a prior selection of the items' symmetry/asymmetry status. This paper proposes a Bayesian IRT model that accounts for symmetric and asymmetric items in a flexible but parsimonious way. That is achieved by assigning a finite mixture prior to the skewness parameter, with one of the mixture components being a point mass at zero. This allows for analyses under both model selection and model averaging approaches. Asymmetric item curves are designed through the centred skew normal distribution, which has a particularly appealing parametrization in terms of parameter interpretation and computational efficiency. An efficient Markov chain Monte Carlo algorithm is proposed to perform Bayesian inference and its performance is investigated in some simulated examples. Finally, the proposed methodology is applied to a data set from a large‐scale educational exam in Brazil.
Cardiac donors with renal impairment: Usage and outcomes after heart transplant
Authors: Jaiswal Abhishek , Baran David A , Sinphurmsukskul Supanee , Baker William L 
Published: July 2022

AbstractIntroductionUtilization of hearts from donors with significant renal dysfunction and the impact of donor renal function on outcomes following heart transplant (HT) is unknown. We sought to investigate the trends, characteristics and outcomes associated with these donor hearts and the impact of donor renal function on survival and graft failure in adult HT recipients.MethodsWe reviewed the Scientific Registry of Transplant Recipients (SRTR) and summarized trends, characteristics and outcomes of hearts from adult donors by renal impairment. Single‐organ HTs were evaluated and stratified by donors with estimated glomerular filtration rate (eGFRs) < and ≥30 ml/min. We constructed Cox proportional hazards regression models to compare time‐to‐mortality over 30‐day, 1‐, 3‐, and 5‐year time‐horizons between groups, and the association of donor eGFR group with graft failure.ResultsA total of 162,586 adults were evaluated for cardiac donation, of which, 22,780 (14%) had an eGFR ≤ 30 ml/min. Donors with an eGFR ≤ 30 ml/min increased over time, from 7.2% (358/4966) in 2000 to a high of 19.5% (2283/11,728) in 2020. Such donors were significantly more likely discarded (not offered (7.9% vs. 9.8%, p < .001) or accepted (62.6% vs. 72.2%, p < .001), and less likely to be transplanted (18.0 % vs. 29.5%; p < .001). Of 41,044 HT recipients, 3906 (9.5%) had hearts from such donors. Primary graft failure was similar between groups (OR 1.20, 95% CI .91–1.58; p = .1) while adjusted mortality was lower for recipients from donors with eGFR ≤ 30 ml/min.ConclusionsMore than two‐third of hearts from donors with renal dysfunction are discarded. Recipients from donors with renal dysfunction sustained lower mortality post HT during the study period. Increased evaluation and utilization of donors with renal dysfunction has the potential to expand the critically low donor pool.
Clinical relevance of amyloid in prostate samples: a report on 40 patients
Authors: Foix Maria Pané , Calvo Davinia Fernandez , Condom i Mundó Enric , Novo José Francisco Suarez , Serra Eva Merino , Benett Josep Ronald Garcia , Gàllego Montserrat Gomà , Viladomat Sergi Yun , Julià Francesc Vigués , Vidal i Bel August 
Published: July 2022

ObjectiveTo describe the clinical findings in patients with incidental prostatic amyloidosis.Patients and methodsRetrospective search in the database of the Department of Pathology, Hospital de Bellvitge, for prostate specimens with amyloid. Congo red and immunohistochemical staining of the sections. Review of the patients’ clinical charts for symptoms attributable to systemic amyloidosis.ResultsAmyloid deposition in the prostate was identified and reported in 40 patients between 2001 and 2022. Median age was 76.5 years (range = 62–90 years). Prostate cancer was diagnosed in 25 patients. Only four patients had a previous diagnosis of amyloidosis. In the remaining 36 the prostate sample (31 needle biopsies, two transurethral resections (TUR), two simple prostatectomies, one radical cystectomy for bladder cancer) provided the initial diagnosis. Amyloid deposits were mainly located in the wall of small vessels and rarely in the prostatic stroma. Immunohistochemistry was available in 32 cases, 26 of which were positive for TTR. All patients showed at least one symptom indicative of systemic amyloidosis, the most frequent being hearing loss (55%), carpal tunnel syndrome (42,5%) or other osteoarticular symptoms (tendinopathies, osteoarthritis), cataracts (37.5%) and cardiac symptoms (32.5%), among others.ConclusionThe prostate is a target tissue for amyloid deposition. The incidental finding of amyloid in prostate corresponds, in the majority of cases, to previously undiagnosed systemic TTR amyloidosis in patients lacking signs of heart involvement but having mainly osteoarticular symptoms, hearing and visual impairment.
Sodium caseinate and OSA‐modified starch as carriers for the encapsulation of lutein using spray drying to improve its water solubility and stability
Authors: Zhang Bo , Yao Yishun , Lu Yifan , Xu Yanfeng , Li Wenhao , Yan Wenjie 
Published: July 2022

SummaryLutein is a fat‐soluble substance with plentiful unsaturated carbon–carbon double bonds in the chemical structure. Spray‐drying formulations of lutein emulsions stabilised by a mixture of sodium caseinate (CS) and octenyl succinic anhydride‐modified starch (OS) yield lutein microcapsules. The yield (19.3–65.8%), encapsulation efficiency (74.7–82.9%), moisture (0.92–3.50%), wettability (226.8–392.4 s) and solubility (65.3–95.7%) were obtained in this study. The formulations with CS:OS (7:3) presented the excellent encapsulation efficiency (82.9%), glass transition temperatures (126.77 °C) and retention rate at 50 °C (80.51%), 25 °C (82.49%), and 4 °C (90.68%), and in UV light (75.44%) and lightness (80.40%) after 15 days. Based on the study, encapsulation would be an alternative for generating high value‐added products and could promote lutein's use as a functional ingredient with a ‘clean label’.
Evaluation of formulation design on the physical and structural properties of commercial cream cheeses
Authors: Kim Jiuk , Watkinson Philip , Matia‐Merino Lara , Smith Jeremy R. , Golding Matt 
Published: July 2022

SummaryThis study investigated how the compositional properties and formulation design of commercial cream cheese products model cheese influenced physical and structural properties as compared to a model cheese composition. Of the seven products evaluated, three were block format (B), two were spreadable (S) and two were spreadable light (SL), with fat contents ranging from 13.7 to 35.7%. The majority of cream cheese products indicated the inclusion of starter culture, and all formulations contained one or more stabilisers. Protein/moisture (p/m) ratio, i.e. the effective protein concentration in the non‐fat substance, was seen to most strongly correlate with material properties, with a positive slope for fracture stress (R2 = 0.808) and modulus of deformability (R2 = 0.721). In terms of outliers, the datapoint for SL2 on this modulus versus p/m graph was lower than its regression line, and one rationale is that lower fat content (13.7%) gave a lower modulus from the milkfat component at 10°C test temperature. B1, with the highest p/m of 0.17, had a more dense distribution of larger fat globules coated with proteins than B2 and B3. Fracture stress and modulus of deformability were noted to be higher for full‐fat than for lower fat cheese. In all products, elastic characteristics dominated viscous flow as expected. Findings have demonstrated that significant variance exists across the material properties of commerical cream cheeses, and which shows specific dependencies on their formulation.
Formulation and evaluation of functional attributes of low‐fat mozzarella cheese using okra mucilage as a fat replacer
Authors: Akhtar Aqsa , Khan Rabbia , Khalid Nauman 
Published: July 2022

SummaryMozzarella cheese is a fermented product comprised of 30–45% milk fat on a dry basis. The milk fat gives the mozzarella its desirable stretchable properties which are demanding in food processing industries. The current study was designed to use okra mucilage as a carbohydrate‐based fat replacer to prepare low fat mozzarella cheese. For this purpose, the different concentrations of okra mucilage (0.25 to 1.0% (v/v)) were used. The fat contents were significantly reduced in all treatments and the addition of okra mucilage with a concentration of 0.25% (T2) was considered best for its organoleptic properties and 1% (T4) has a positive impact on the textural, functional attributes of low‐fat mozzarella cheese.
The interaction between the Dbf4 ortholog Chiffon and Gcn5 is conserved in Dipteran insect species
Authors: George Smitha , Blum Hannah R. , Torres‐Zelada Eliana F. , Estep Grace N. , Hegazy Youssef A. , Speer Gina M. , Weake Vikki M. 
Published: July 2022

AbstractChiffon is the sole Drosophila ortholog of Dbf4, the regulatory subunit for the cell‐cycle kinase Cdc7 that initiates DNA replication. In Drosophila, the chiffon gene encodes two polypeptides with independent activities. Chiffon‐A contains the conserved Dbf4 motifs and interacts with Cdc7 to form the Dbf4‐dependent Kinase (DDK) complex, which is essential for a specialized form of DNA replication. In contrast, Chiffon‐B binds the histone acetyltransferase Gcn5 to form the Chiffon histone acetyltransferase (CHAT) complex, which is necessary for histone H3 acetylation and viability. Previous studies have shown that the Chiffon‐B region is only present within insects. However, it was unclear how widely the interaction between Chiffon‐B and Gcn5 was conserved among insect species. To examine this, we performed yeast two‐hybrid assays using Chiffon‐B and Gcn5 from a variety of insect species and found that Chiffon‐B and Gcn5 interact in Diptera species such as Australian sheep blowfly and yellow fever mosquito. Protein domain analysis identified that Chiffon‐B has features of acidic transcriptional activators such as Gal4 or VP16. We propose that the CHAT complex plays a critical role in a biological process that is unique to Dipterans and could therefore be a potential target for pest control strategies.
The proximal and distal effects of mortality salience on COVID‐19‐related health perceptions and intentions
Authors: Fairlamb Samuel , Cinnirella Marco , Iahr Inbal 
Published: July 2022

AbstractHealth preventative measures are important in reducing transmission of COVID‐19, yet death‐related thoughts might hinder preventative action. Using two online samples (N = 948), we examined how mortality salience (MS) may produce health‐related proximal and distal defenses relevant to COVID‐19, examining health optimism and appearance self‐worth as moderators. MS decreased perceived vulnerability as a proximal defense for those with high health optimism (Study 1), while those with low health optimism decreased perceived response efficacy of face masks and intention to wear a protective face mask (Study 2). Additionally, those with high appearance self‐worth displayed increased intention to wear an aesthetically appealing face mask as a distal defense to MS (Study 2). Our findings demonstrate the importance of considering how mortality concerns may channel health‐defeating and health‐promoting behaviors in respect to COVID‐19 and provide insight into how to produce sustained engagement in health preventative action to combat the pandemic.
Secondary school teachers' use of online formative assessment during COVID‐19 lockdown: Experiences and lessons learned
Authors: Veugen Maria Joanna , Gulikers Judith Theresia Maria , den Brok Perry 
Published: July 2022

AbstractIntroductionDuring the COVID‐19 lockdown in 2020, teachers had to shift their teaching and assessment to online. Formative assessment (FA) can help teachers to engage, guide and monitor students' (online) learning. However, more knowledge is needed of how teachers could use the full FA process online.MethodsIn this study data from 50 secondary school teachers, who taught different grade levels and subjects and joined a FA learning network that started before and continued during the lockdown, were collected. The study investigates how they used online FA practices differently than face‐to‐face FA, what challenges and opportunities they experienced in online FA and what lessons they learned and intended to keep. This mixed methods study used data from a questionnaire, interviews and webinars that were segmented, coded and analysed.ResultsResults showed that many teachers implemented new FA strategies and adopted, more often than in their face‐to‐face practice, all the five phases of the FA process in an aligned matter in online FA. Teachers indicated opportunities in stimulating student engagement and guiding and monitoring student learning more at an individual level in the online FA process, but also experienced challenges, mainly in lack of interaction online.DiscussionThe sudden and necessary shift to online FA, due to the COVID‐19 lockdown, challenged teachers to more fundamentally reconsider their assessment practices and assumptions. Teachers intended to make use of these learned lessons to improve their future (blended) FA practice.
Associated factors of primary snoring and obstructive sleep apnoea in patients with sleep bruxism: A questionnaire study
Authors: Huang Zhengfei , Aarab Ghizlane , Chattrattrai Thiprawee , Su Naichuan , Volgenant Catherine M. C. , Hilgevoord Antonius A. J. , de Vries Nico , Lobbezoo Frank 
Published: July 2022

AbstractBackgroundBy being aware of the associated factors of primary snoring (PS) and obstructive sleep apnoea (OSA) in sleep bruxism (SB) patients, dentists may contribute to the screening and early recognition of SB patients with PS or OSA.ObjectiveTo identify the associated factors of PS and OSA from questionnaire‐based data in SB patients.MethodsA total of 968 self‐reported SB patients (31.6% men; median age 44.5 years) were retrospectively enrolled. Self‐reported sleep‐related breathing status (viz., no sleep‐related breathing condition, PS and OSA) was the dependent variable. Independent variables were questionnaire‐based data on demographics, lifestyle, psychological status, pain and sleep.ResultsFor PS, no statistically significant associated factor was identified in analyses. For OSA, increased age (OR = 1.04 [1.03–1.06]), male gender (OR = 3.33 [2.17–5.00]), daily alcohol consumption (OR = 1.96 [1.18–3.33]), depression (OR = 1.10 [1.06–1.14]), daytime sleepiness (OR = 2.94 [1.85–4.76]) and high risk of gastroesophageal reflux disease (GERD; OR = 2.63 [1.52–4.76]) were found to be significant risk factors, while high risk of temporomandibular disorder (TMD) pain (OR = 0.51 [0.30–0.86]) and chronic pain (OR = 0.73 [0.59–0.90]) were significant protective factors. These results were confirmed in the subsequent network analysis.ConclusionWithin the limitations of this study, no associated factor is identified for PS. For OSA, dentists should keep in mind that increased age, male gender, daily alcohol consumption, depression, daytime sleepiness and high GERD risk are associated with increased OSA risk in SB patients, while high TMD‐pain risk and chronic pain are associated with decreased OSA risk in this population.
Single‐dose pharmacokinetics and bioavailability of a novel extended duration transdermal buprenorphine solution in cats
Authors: Freise Kevin J. , Reinemeyer Craig , Warren Katherine , Lin Ting‐Li , Clark Terrence P. 
Published: July 2022

AbstractA novel transdermal buprenorphine solution (TBS) was developed for evaluation in order to make available an extended duration opioid analgesic for cats. Healthy adult cats were administered a single TBS dose of 10 mg (1.57–4.35 mg/kg), 30 mg (4.72–13.0 mg/kg), or 50 mg (7.87–21.7 mg/kg) (4 cats per group) applied topically to the unclipped dorsal cervical skin and plasma buprenorphine concentrations were evaluated through 7 days. To determine the absolute bioavailability of TBS, healthy cats were administered single TBS dose of 20 mg (3.33–4.76 mg/kg) or 0.05 mg (0.008–0.011 mg/kg) IV buprenorphine (6 cats per group). The mean ± standard deviation maximum plasma buprenorphine concentrations (Cmax) were 10.5 ± 6.28, 18.6 ± 8.68, and 22.5 ± 4.47 ng/ml following 10, 30, and 50 mg doses, respectively, with the time of Cmax occurrence (tmax) typically occurring at 2–12 h post‐dosing. Mean plasma buprenorphine terminal half‐lives ranged between 78.3 and 91.2 h. Increasing the dose threefold and fivefold from the 10 mg dose increased the exposure by 2.8‐ and 3.6‐fold, respectively, indicating that plasma buprenorphine exposure increased in a less than proportional manner at doses >30 mg. Transient sedation, mydriasis, and euphoria were observed within 4 h post‐dosing. Mean rectal temperatures were increased 0.6–0.9°C greater than baseline (37.4–37.8°C) through 168 h post‐dosing. The absolute bioavailability was 16.0% (90% CI: [11.8%–21.7%]). Flip‐flop pharmacokinetics were observed with a terminal elimination half‐life of 0.82 ± 0.13 and 64.9 ± 15.0 h for IV buprenorphine and 20 mg of TBS, respectively. A single administration of TBS over a range of doses resulted in extended plasma buprenorphine concentrations and opioid physiological and behavioral effects.
Using the flexibilities of Article 30 TRIPS to implement patent exceptions in pursuit of Sustainable Development Goal 3
Authors: Tesoriero Amy 
Published: July 2022

AbstractDespite over 25 years passing since TRIPS entered into force, the full potential of the patent exceptions provision under Article 30 TRIPS (Article 30) is yet to be realised. The hesitation by developing states to implement new patent exceptions in their domestic laws has presented a barrier to reconciling the tension between protecting patent rights and achieving access to essential medicines for all as committed by states under Sustainable Development Goal 3 (SDG 3). This article addresses the uncertainty of the interpretation of Article 30 through a doctrinal analysis of treaty interpretation rules and the recent Australia‐Tobacco Plain Packaging decisions. It proposes an original interpretation of Article 30 that permits public interest considerations, and uses this interpretation to justify a proposed stockpiling exception for pandemic and epidemic preparedness aimed at facilitating access to essential medicines to achieve SDG 3. Accordingly, developing states should feel more confident about implementing patent exceptions tailored to their public interest needs in pursuit of SDG 3.