bluuebunny/crossref_metadata_2025_split huggingface dataset:
5‐Fluorouracil reduces the fibrotic scar via inhibiting matrix metalloproteinase 9 and stabilizing microtubules after spinal cord injury
Authors: Xu Yang , He Xiuying , Wang Yangyang , Jian Jiao , Peng Xia , Zhou Lie , Kang Yi , Wang Tinghua 
Published: August 2022

AbstractAimsFibrotic scars composed of a dense extracellular matrix are the major obstacles for axonal regeneration. Previous studies have reported that antitumor drugs promote neurofunctional recovery.MethodsWe investigated the effects of 5‐fluorouracil (5‐FU), a classical antitumor drug with a high therapeutic index, on fibrotic scar formation, axonal regeneration, and functional recovery after spinal cord injury (SCI).Results5‐FU administration after hemisection SCI improved hind limb sensorimotor function of the ipsilateral hind paws. 5‐FU application also significantly reduced the fibrotic scar formation labeled with aggrecan and fibronectin‐positive components, Iba1+/CD11b+ macrophages/microglia, vimentin, chondroitin sulfate proteoglycan 4 (NG2/CSPG4), and platelet‐derived growth factor receptor beta (PDGFRβ)+ pericytes. Moreover, 5‐FU treatment promoted stromal cells apoptosis and inhibited fibroblast proliferation and migration by abrogating the polarity of these cells and reducing matrix metalloproteinase 9 expression and promoted axonal growth of spinal neurons via the neuron‐specific protein doublecortin‐like kinase 1 (DCLK1). Therefore, 5‐FU administration impedes the formation of fibrotic scars and promotes axonal regeneration to further restore sensorimotor function after SCI.
GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/β‐catenin and ALK5/SMAD2/3 pathways
Authors: Frohlich Jan , Kovacovicova Kristina , Raffaele Marco , Virglova Tereza , Cizkova Eliska , Kucera Jan , Bienertova‐Vasku Julie , Wabitsch Martin , Peyrou Marion , Bonomini Francesca , Rezzani Rita , Chaldakov George N. , Tonchev Anton B. , Di Rosa Michelino , Blavet Nicolas , Hejret Vaclav , Vinciguerra Manlio 
Published: August 2022

AbstractObjectiveGDF11 is a member of the TGF‐β superfamily that was recently implicated as potential “rejuvenating” factor, which can ameliorate metabolic disorders. The main objective of the presented study was to closely characterize the role of GDF11 signaling in the glucose homeostasis and in the differentiation of white adipose tissue.MethodsWe performed microscopy imaging, biochemical and transcriptomic analyses of adipose tissues of 9 weeks old ob/ob mice and murine and human pre‐adipocyte cell lines.ResultsOur in vivo experiments employing GDF11 treatment in ob/ob mice showed improved glucose/insulin homeostasis, decreased weight gain and white adipocyte size. Furthermore, GDF11 treatment inhibited adipogenesis in pre‐adipocytes by ALK5‐SMAD2/3 activation in cooperation with the WNT/β‐catenin pathway, whose inhibition resulted in adipogenic differentiation. Lastly, we observed significantly elevated levels of the adipokine hormone adiponectin and increased glucose uptake by mature adipocytes upon GDF11 exposure.ConclusionWe show evidence that link GDF11 to adipogenic differentiation, glucose, and insulin homeostasis, which are pointing towards potential beneficial effects of GDF11‐based “anti‐obesity” therapy.
The Value of Museums in Averting Societal Collapse
Authors: Janes Robert R. 
Published: August 2022

AbstractCurrent research suggests that societal collapse is in progress. The indicators of societal collapse include untenable economic inequality; the spread of authoritarian governments; the collapse of biodiversity; an economic system dependent on the fallacy of endless growth, consumption, and debt, and the failure of governments institutions to respond to these crises. This article explores the implications of societal decline for museums as civil society organizations, including an examination of the untapped potential of museums to contribute to the reimagining and transitioning to a new society in the face of collapse or possible extinction. Given the uncertainty of the world, collapse is not inevitable. Museums, as key civic and intellectual resources with ethical responsibilities, must now examine the meaning and value of their work. As institutions of the commons, belonging to and affecting the public at large, museums can commit to enhancing societal wellbeing and the durability of the more‐than‐human world. There is an important lesson in the history of museums, and that is their ability to learn and adapt as circumstances require. Urgent museum participation is now possible and essential.
Functional development of olfactory nerve‐related neural circuits in the embryonic chick forebrain revealed by voltage‐sensitive dye imaging
Authors: Sato Katsushige , Momose‐Sato Yoko 
Published: August 2022

AbstractMultiple‐site optical recordings with NK2761, a voltage‐sensitive absorption dye, were applied to the embryonic chick olfactory system, and the functional development of olfactory nerve (N.I)‐related neural circuits was examined in the forebrain. The stimulation of the N. I elicited neural responses in N.I‐olfactory bulb (OB)‐forebrain preparations at the embryonic 8–12 day (E8‐E12) stages. At the E11 stage, we functionally identified two circuits projecting from the OB to the forebrain. The first circuit passed through the ventral side of the forebrain and spread in the dorso‐caudal direction, whereas the second circuit passed through the dorsal side to the first circuit. Pharmacological experiments showed that N‐methyl‐D‐aspartate (NMDA) receptor function was more significant for the transfer of sensory information in these circuits. The functional development of N.I‐related circuits was investigated, and the results obtained revealed that the ventral circuit was generated earlier than the dorsal circuit. Neural responses in the ventral circuit were detected from the E9 stage in normal physiological solution and the E8 stage in Mg2+‐free solution, which activated NMDA receptor function. At the E10 stage, neural responses in the dorsal circuit were clearly recognised in addition to ventral responses. We attempted to identify possible candidates for relay nuclei in the forebrain by comparing contour line maps of the optical signal amplitude with previously reported neuroanatomical data. The results suggest that N.I‐related neural circuits from the periphery to the subpallium functionally mature earlier than those to the pallium during ontogenesis.
A proposal to enhance data quality and FAIRness
Authors: Triki Zegni , Bshary Redouan 
Published: August 2022

AbstractIn recent years, we witnessed an increasing number of funding agencies, scientific journals and scientists agreeing that society and science benefit from open access to research data. Benefits derive mainly from increased access to knowledge for all and improved transparency and credibility in academia. However, despite the advances in open science and open data, three significant aspects still need considerable policing: data quality, the accompanying summaries with basic information of the data files (i.e. metadata) and computational codes used to generate the research outcomes. Only by having these three components together, we can achieve efficient data sharing and reuse, and hence higher transparency. Here, we present two complementary approaches that potentially can help with shared data quality: (i) data file(s) sharing should be guided step‐by‐step in public archives with mandatory metadata, and (ii) journals creating assistant data editor positions at editorial boards with a leading role in data quality and computational reproducibility. Forty‐four editors‐in‐chief in the field of behaviour, ecology and evolution shared their opinion with us regarding these two approaches. Although most of the views were divided, the majority estimated that their current editorial board members do not have the necessary skills to assess the quality of shared data. Since data are the core of research studies, we should consider not only data presence but also quality as a requirement for publication.
Realization of natural language processing and machine learning approaches for text‐based sentiment analysis
Authors: Naithani Kanchan , Raiwani Yadav Prasad 
Published: August 2022

AbstractThe leading intention of the current paper is to review the research work accomplished by various researchers to achieve sentiment analysis on the text and to elaborate on natural language processing (NLP) and various machine learning algorithms used to evaluate textual sentiments. In this study, primitive cases are considered that used crucial algorithms, and knowledge that can be opted for sentiment analysis. A survey of the work that has been done till now is conducted observing the results and outcomes concerning varying parameters of various researchers who worked on previously existing as well as novel and hybrid algorithms opting legion methodologies. The fundamental algorithms like Support Vector Machine (SVM), Bayesian Networks (BN), Maximum Entropy (MaxEnt), Conditional Random Fields (CRF) and Artificial Neural Networks (ANN) are also discussed to achieve practice percentage and accuracy score in the field of NLP, sentiment analysis and text analytics. Various other novel approaches and algorithms like CNN, LSTM, KNN, K*, K‐means, K‐means++, SOM and ENORA, along with their limitations and the performance metrics providing accuracies for major open data sets are also analyzed.
Design of decision model for sensitive crop irrigation system
Authors: Thakur Anita , Aggarwal Prakriti , Dubey Ashwani Kumar , Abdelgawad Ahmed , Rocha Alvaro 
Published: August 2022

AbstractAgriculture Industry is highly dependent on environmental and weather conditions. Many times, crops are spoiled because of sudden changes in weather. Therefore, we need a decision model to take care the water requirement of sensitive crops of agriculture industry. The proposed work presents a novel and proficient hybrid model for sensitive crop irrigation system (SCIS). For implementation of the model, brassica crop is taken. The duration and amount of water to be supplied is based upon the weather prediction and soil condition information. The decision model is developed using adaptive neuro‐fuzzy inference system (ANFIS) and artificial neural network (ANN) for brassica crops. In this model, if the input data values are available in range, then ANFIS model would be preferred and if the data sets are available for training, testing and validation then ANN model would be the best choice. The soil moisture, soil status in terms of temperature and leaf wetness are the input and flow control of sprinklers is the out for SCIS. The predicted outputs are analysed to assert the suitability of the proposed approach in the brassica crops. The proposed SCIS achieved an accuracy of 91% and 99% for ANFIS and ANN models respectively.
Real‐world outcomes of molecular targeted agents for patients with hepatocellular carcinoma over 80 years old
Authors: Sato Rui , Moriguchi Michihisa , Iwai Kenji , Tsuchiya Satoshi , Seko Yuya , Takahashi Aya , Kobayashi Kazufumi , Ogasawara Sadahisa , Watanabe Shunji , Morimoto Naoki , Kato Naoya , Itoh Yoshito , Aramaki Takeshi 
Published: August 2022

AbstractAimThere is insufficient evidence regarding the safety and efficacy of molecular targeted agents (MTAs) for elderly patients with hepatocellular carcinoma (HCC), who are likely to be vulnerable to adverse events (AEs) of therapy. The aim of this study was to compare sorafenib and lenvatinib use in elderly patients with HCC from the viewpoint of overall survival (OS) and rate of AE‐induced MTA discontinuation.MethodsThis retrospective study included patients with HCC over 80 years old who received first‐line molecular targeted therapy (MTT) at four hospitals between June 2009 and September 2019. They were divided into three groups according to the era and type of first‐line MTA: E1‐Sora (sorafenib, between 2009 and 2016), E2‐Sora (sorafenib, between 2017 and 2019), and E2‐Len (lenvatinib, between 2017 and 2019).ResultsThe study included 173 patients (E1‐Sora, n = 79; E2‐Sora, n = 50; E2‐Len, n = 44) with a median age of 81.9 years (range, 80–93 years). Median OS was 15.1 months in the entire cohort (E1‐Sora, 12.7 months; E2‐Sora, 20.5 months; E2‐Len, 10.3 months). The rate of treatment discontinuation due to AEs was high in the entire cohort, especially in E1‐Sora and E2‐Len (49.4% in E1‐Sora, 28.0% in E2‐Sora, and 54.6% in E2‐Len, p = 0.0753). More E2‐Sora patients received subsequent MTT than E2‐Len patients (E2‐Sora, 50%; E2‐Len, 28.6%; p = 0.0111).ConclusionBoth sorafenib and lenvatinib were effective and feasible for elderly patients with HCC. In terms of discontinuation due to AEs and subsequent MTT, sorafenib might be more desirable for elderly patients with HCC over 80 years.
Oral hygiene status and factors related to oral health in hospitalized patients with schizophrenia
Authors: Kurokawa Yoshiya , Watanabe Satoshi , Miyabe Satoru , Ishibashi Kenichiro , Yamamoto Satoshi , Goto Mitsuo , Hasegawa Shogo , Miyachi Hitoshi , Fujita Kohei , Nagao Toru 
Published: August 2022

AbstractObjectiveThis study aimed to elucidate the oral hygiene status and the factors associated with poor oral hygiene among patients with schizophrenia.MethodsThe relationships of oral hygiene status (calculus index [CI], debris index [DI]), the mean number of decayed‐missing‐filled teeth (mean DMFT), and Revised Oral Assessment Guide (ROAG) with related factors (hospitalization, chlorpromazine equivalents [CPZE], age, Barthel Index [BI], frequency of cleaning teeth, and self‐oral hygiene ability) among 249 hospitalized schizophrenic patients were investigated.ResultsThe results for oral hygiene status were as follows: median (range); CI 0.5 (0–6.0), DI 1.7 (0–6.0), ROAG 10.0 (7.0–15.0); and mean DMFT 21.7 ± 7.3. The average CPZE was 524.4 ± 353.6 mg (mean ± SD), and the BI was 76.4 ± 30.7. There was a negative correlation between BI and DI (r = −0.34), and a positive correlation between age and mean DMFT (r = 0.57). Male patients tended to have worse oral conditions (ROAG) than females. The least‐squares multiple regression analysis revealed that BI for DI, age for mean DMFT, sex for ROAG, and self‐oral hygiene ability for CI, DI, and mean DMFT were factors related to oral health status.ConclusionPatients with schizophrenia tended to have poor oral hygiene. BI, being male, and low activities of daily living were associated with poor oral hygiene. Furthermore, advanced age was associated with an increased risk of dental caries.
Physicochemical properties and correlation analysis of retrograded starch from different varieties of sorghum
Authors: Gao Fei , Li Xiaoqiang , Li Xin , Liu Ziwei , Zou Xiangyu , Wang Lidong , Zhang Hongwei 
Published: August 2022

SummarySorghum germplasm resources were abundant, and their comprehensive utilisation was also more in‐depth. Starch had attracted much attention as the main component in grain, but starch retrogradation limited its better development and utilisation. Therefore, the property changes of sorghum starch retrogradation were studied. The differences in the properties of the four kinds of sorghum starches during retrogradation were mainly due to composition and structure among the varieties. With the increase in retrogradation days, the order of L1 starch was better at 0.994, the retrogradation rate of L13 starch increased by 36.23%, and the recrystallisation degree of H5 starch was 0.064 worse than that of native starch. However, the physicochemical properties of H1 retrograded starch were different from those of the other three. It was shown that the solubility increased to 47.67%, the transparency was 43.36%, and the water‐holding capacity was 91.35%. Retrogradation made that the surface of sorghum starch gel fragments had an orderly scale‐like structure, which did not cause the generation of new groups, reduced the crystalline strength and the energy required for gelatinisation. The crystallisation rate was positively correlated with syneresis, swelling and orderliness, as well as T0, Tp, Tc and ΔH, and negatively correlated with water‐holding capacity.
Perception of export intenders on relevant resources and competences for the internationalization of vocational education and training (VET) providers
Authors: Kassberg Gunnar , Dornberger Utz 
Published: August 2022

AbstractThe local market conditions for VET in Germany naturally affect the exportability of these educational products. In the rarest of cases, education and training products are transferable to foreign markets without any adaptation. The existing literature on international VET cooperation focuses on several transfer aspects as well as case studies of active exporters, investigating drivers and challenges of foreign engagement or analysing international business models. The perspective of resources and competences of VET providers going international has not been considered so far, failing to understand the relevancy of specific factors. This study analyses the required resources and capabilities of internationally active VET organizations (exporters) as well as those without any international experience, but intending to internationalize (intenders). Based on a literature review, this study applied four constructs of company resources and six constructs of competences necessary for conducting international business, each containing two to five indicators. Applying a quantitative research approach, data from 43 exporters and 37 intenders were collected to explore the most relevant resources and competences of both groups. Based on a ranking of all factors, a significant difference in terms of relevance perception was detected comparing both groups. Exporters rate relational resources, intercultural competence, physical resources, and product adaption abroad as much more relevant than export intenders do. Intenders, on the other hand, seem to rely heavily on their strengths in the national market and give high priority to organizational resources like quality management and strategy development for opening up international markets. These findings indicate that support programmes fostering the internationalization of VET providers should put more emphasis on the relevant resource and competence development that export intenders need.
Optimal ordering decisions for an omnichannel retailer with ship‐to‐store and ship‐from‐store
Authors: Wang Hang , Zhang Wen , He Yi 
Published: August 2022

AbstractMany retailers have recently integrated online and offline channels to give consumers a seamless shopping experience. Our study considers an omnichannel retailer fulfilling order delivery by adopting two common strategies, ship‐to‐store (STS) and ship‐from‐store (SFS), when one of the channels is in short supply. We develop a newsvendor model to investigate the effects of these two omnichannel fulfillment strategies on the retailer's order decisions and expected profits. The analysis reveals the key roles of the external market and inventory cost of different channels in adopting an omnichannel strategy. An interesting finding is that the retailer may adopt the STS (SFS) strategy and take the offline (online) channel as a showroom (virtual webroom) to obtain higher profits than without adopting an omnichannel strategy.
The Politics of Emigration in Europe: A Research Agenda*
Authors: Kyriazi Anna , Mendes Mariana S. , Rone Julia , Weisskircher Manès 
Published: August 2022

AbstractWhile the politics of immigration in destination countries has been a prominent topic of research in comparative political science in Europe, the same does not apply to emigration and to the perspective of peripherical EU countries. This is true even though the flows of people moving from east to west and from south to north pose potentially significant challenges to ‘sending countries’ in Europe. This article sets up a research agenda aimed at contributing to redress this imbalance. It highlights the need to explore more systematically themes such as (1) the impact of emigration on the political behaviour of both those who stay and those who leave and (2) and how emigration is framed and politicized by relevant societal actors. Ultimately, it draws attention to the fact that a lot of the questions that have been asked about ‘entry’ (immigration) need to be asked about ‘exit’ too (emigration).
Dermoscopy as response evaluation tool for cutaneous malignant melanoma metastases treated with Talimogene Laherparepvec: a prospective feasibility study
Authors: Stahlie E.H.A. , van Akkooi A.C.J. , Plasmeijer E. 
Published: August 2022

AbstractBackgroundCurrently, the response of cutaneous melanoma metastases (CMM) to treatment with Talimogene Laherparepvec (T‐VEC) is evaluated by clinical examination, macroscopic lesion photography and 3‐monthly PET‐CT scans. When a complete response (CR) is suspected, biopsies are taken for histopathological confirmation.ObjectivesWe set out to investigate the feasibility of dermoscopy in monitoring the response to T‐VEC in a pilot study.MethodsSix patients with CMM treated with T‐VEC monotherapy were enrolled in the pilot study. Patients were treated with T‐VEC according to protocol, and the response was monitored with clinical examination, macroscopic lesion photography and 3‐monthly PET‐CT scans. For this study, 1–3 cutaneous metastases per patient were selected. Macroscopic and dermoscopic pictures of these metastases were taken at baseline, prior to each treatment with T‐VEC and prior to histological biopsy. The pictures were evaluated by two investigators, using a colour‐based pattern classification.ResultsIn total, 11 CMM were dermoscopically assessed, 93% was located on the extremities. Four metastases had a blue pattern, two metastases had a pink pattern, three metastases had a brown pattern, and two metastases had mixed patterns. Metastases with a pink pattern harboured glomerular and arborizing vessels that diminished and vanished during treatment T‐VEC, indicating CR. The remaining metastases did not show changes on a dermoscopic level that were not also seen on macroscopic level. Five patients achieved CR to T‐VEC, one patient is still on treatment.ConclusionsThese results suggest that for CMM with a pink pattern, dermoscopy can provide additional information regarding the response to T‐VEC. For cutaneous metastases with a blue, brown or a mixed patterns, dermoscopy did not provide additional information on top of the information obtained through physical examination and lesion photography. More studies would be needed to determine the exact role of dermoscopy in the evaluation of CMM.