bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward a Du Boisian paradigm of family science
Authors: Battle Brittany Pearl , Serrano Uriel 
Published: May 2022

AbstractWe offer an invitation to theDu Boisian paradigm for family science. We outline this paradigm in relation to Guba and Lincoln's ontological, epistemological, and methodological questions and our addition of the phenomenological question. A Du Boisian paradigm meets the need for a social justice orientation in social science scholarship, which is equipped to identify, contextualize, and respond to oppression across the globe. A social justice orientation recognizes the centrality of the carceral state and racial capitalism and tends to their ramifications in seeking the transformation of the conditions that produce harm. We offer historical and contemporary examples from diverse disciplines on myriad topics to highlight social justice‐oriented scholarship that has already done the work of pushing the bounds of how we engage with academic research, theory, and praxis, as well as points of consideration for work yet to be done in service of eradicating oppression.
Cross‐sectional associations between cortical thickness and independent gait domains in older adults
Authors: Wang Yingzhe , Jiang Yanfeng , Lu Heyang , Tian Weizhong , Li Peixi , Xu Kelin , Fan Min , Zhao Xiaolan , Dong Qiang , Jin Li , Chen Jinhua , Cui Mei , Chen Xingdong 
Published: May 2022

AbstractBackgroundAlthough the prevalence of gait disturbance is increasing with population aging, our understanding of its underlying neural basis is still limited. The precise brain regions linked to specific gait domains have not been well defined. In this study, we aim to investigate the associations of cortical thickness and different gait domains, and to explore whether these associations could be explained by cerebral small vessel disease.MethodsA total of 707 community‐dwelling participants from the Taizhou Imaging Study (mean age: 60.2 ± 3.0 years, 57.4% female) were involved. All participants underwent brain MRI and gait assessment. We obtained quantitative gait parameters using wearable devices and then summarized them into three independent gait domains through factor analysis. Cortical thickness was analyzed and visualized using FreeSurfer and Surfstat.ResultsThree independent domains (pace, rhythm, and variability) were summarized from 12 gait parameters. Among gait domains, poorer pace was associated with the thinner cortical thickness of multiple regions, which included areas related with motor function (e.g., the primary motor cortex, premotor cortex, and supplementary motor area), sensory function (e.g., the postcentral gyrus and paracentral lobule), visuospatial attention (e.g., the lateral occipital cortex and lingual gyrus), and identification and cognition (e.g., the fusiform gyrus and entorhinal cortex). Such a relationship was only slightly attenuated after adjustment for cerebrovascular risk factors and cerebral small vessel disease. No statistically significant association was found between cortical thickness and the rhythm or variability domains.ConclusionsPoorer pace is independently associated with thinner cortical thickness in areas important for motor, sensory, cognitive function, and visuospatial attention. Our study emphasizes the importance of cortical thickness in gait control and adds value in investigating neural mechanisms of gait.
WHIRLY1 recruits the histone deacetylase HDA15 repressing leaf senescence and flowering in Arabidopsis
Authors: Huang Dongmei , Lan Wei , Ma Weibo , Huang Rulin , Lin Wenfang , Li Mengsi , Chen Chia‐Yang , Wu Keqiang , Miao Ying 
Published: May 2022

ABSTRACTLeaf senescence is controlled by a complex regulatory network in which robustness is ensured by the activity of transcription factors and epigenetic regulators. However, how these coordinate the process of leaf senescence remains poorly understood. We found that WHIRLY1 interacts with Histone Deacetylase (HDA)15, a Reduced Potassium Dependence3 (RPD3)/HDA1‐type HDA, by using green fluorescent protein‐nanotrap‐mass spectrum assays. The development‐dependent interaction between WHIRLY1 and HDA15 was further confirmed by bimolecular fluorescence complementation assays and co‐immunoprecipitation assays in Arabidopsis. Multi‐omics genome‐wide transcriptome and H3K9 acetylome enrichment analysis showed that HDA15 delays leaf senescence and flowering by repressing the expression of the positive regulators of leaf senescence and flowering, such as LOX2 and LARP1C, and reducing H3K9ac levels at these loci; WHIRLY1 and HDA15 co‐target to the region near the transcription start site of a subset of nutrient recycling‐related genes (e.g., Glutathione S‐transferases 10, non‐coding RNA, and photosystem II protein D1 synthesizer attenuator PDIL1‐2), as well as WRKY53 and ELF4, and co‐repress their expression by removing H3K9 acetylation. Our study revealed a key transcription regulatory node of nutrient recycling and senescence‐associated genes involved in leaf senescence and flowering via the recruitment of HDA15 by the single‐stranded DNA/RNA‐binding protein WHIRLY1.
Wayfinding and spatial perception among adolescents with mild intellectual disability
Authors: Zach S. , King A. 
Published: May 2022

AbstractBackgroundThe study's aim was to examine whether spatial orientation can be improved in students with cognitive disabilities.MethodParticipants were 55 boys and girls with attention deficit and mild cognitive impairment from a special education school. The procedure included an intervention for two experimental groups that studied wayfinding and orientation in the environment: group #1 learned to use a map while navigating, and group #2 learned to use a Google navigation app with voice instructions. Two pre‐post tests were applied: (1) Mental folding test for children (MFTC) and (2) field test with map.ResultsBoth groups improved their ability in navigation and wayfinding. No advantage for one learning method over the other was demonstrated, except for shortened navigation time in the group navigating with a map, and a slight though not significant tendency of improvement in the MFTC task in the group learning navigation using a voice app.ConclusionIt is worth noting that the study did not examine the students' own preferences for the way of learning, which may have implications for the degree of possible improvement. Also, a longer period of the learning process might yield a clearer understanding concerning the differences between the two teaching methods that were examined.
The change in the frequency and severity of facial dermatoses and complaints in healthcare workers during the COVID‐19
Authors: Cosansu Nur Cihan , Yuksekal Gulcan , Kutlu Omer , Umaroglu Mutlu , Yaldız Mahizer , Dikicier Bahar Sevimli 
Published: May 2022

AbstractBackgroundThe coronavirus disease 2019 (COVID‐19) pandemic has led to a dramatic increase in the use of personal protective equipment (PPE). However, the increased use of PPEs may lead to facial skin complaints.AimsThis survey study aims to evaluate the effect of the COVID‐19 pandemic on facial dermatoses and complaints.MethodsA total of 1017 volunteers (age 18–60 years), consisting of healthcare workers, participated in the study. In the present study, healthcare professionals were screened for facial dermatoses and complaints between 1 and 15 April 2021 with an online survey.ResultsThe vast majority of the survey were women (82.4%) and between 26 and 35 years old (49.2%). The most new‐onset facial complaints were acne (25.3%) and lip dryness (29.2%). Along with the pandemic, 50.9% of patients with seborrheic dermatitis had an increase in lesions. Another remarkable result was a 60.5% increase in acne complaints. Moreover, the rate of exacerbations of rosacea, melasma, and lip dryness was increased after the COVID‐19 pandemic (39.1%, 22.0%, and 42.7%, respectively). Exacerbations of seborrheic dermatitis, acne, and lip dryness have occurred more frequently in females when compared to males (p < 0.001).ConclusionsThe current pandemic has had serious impacts on facial dermatoses which had to be managed carefully. Compared to the pre‐pandemic period, there was a significant increase in the frequency and severity of complaints in facial dermatoses related to PPE. If the complaints that may develop due to PPE are known in advance, their development can be prevented by taking precautions against them.
A randomized, controlled trial of intense pulsed light in combination with minocycline hydrochloride for the treatment of inflammatory acne vulgaris
Authors: Qu Huanhuan , Wang Yuanli , Yang Feng , Wang Gang , Gao Lin , Li Kai 
Published: May 2022

AbstractBackgroundIt has been a long‐term debate over the concomitant treatment of inflammatory acne vulgaris using intense pulsed light (IPL) and minocycline due to the photosensitivity of minocycline.ObjectiveWe aimed to evaluate the safety and efficiency of IPL combined with minocycline in treating acne vulgaris in a randomized trial.MethodsA total of 40 patients were enrolled and randomly assigned into two groups which were either given minocycline (100 mg per day) for 8 weeks with IPL treatments three times at weeks 0, 4, and 8, or the same dosage of minocycline only. The evaluations for inflammatory lesion count, Investigator Global Assessment of Acne (IGA), erythema, and purpura indexes were taken before treatment and at weeks 4, 8, and 16.ResultsThere were significant improvements in inflammatory lesion count, IGA scores, and purpura index in both groups as compared with the baseline at week 16 (p < 0.02). The concomitant therapy, but not minocycline only, significantly improved the erythema index (p = 0.40) at the 16th week as compared with the baseline. The group with combined treatment showed significantly continuous improvements in inflammatory lesion counts (p < 0.04) and IGA scores (p ≤ 0.02) at weeks 4, 8, and 16 as compared with the group given minocycline only. No severe adverse effects were observed during the trial.ConclusionIPL in combination with minocycline shows a better clinical efficacy for the treatment of inflammatory acne vulgaris than minocycline alone, and it is safe.
Epidemiology and long‐term neurological sequelae of childhood herpes simplex CNS infection
Authors: Berkhout Angela , Kapoor Vishal , Heney Claire , Jones Cheryl A , Clark Julia E , Britton Philip N , Vaska Vikram L , Lai Melissa M , Nourse Clare 
Published: May 2022

AimHerpes simplex CNS infection is a rare but important cause of neurological disability. Long term outcomes after HSV CNS infection in Australia have not yet been fully described. We sought to provide a comprehensive review of HSV CNS infection in children using a retrospective 13‐year evaluation of statewide laboratory and clinical records and a parent survey conducted at least one year after the initial infection.MethodsAll positive PCR HSV 1 and 2 results from cerebrospinal fluid (CSF) or brain tissue were obtained from Queensland pathology providers for children aged 0–16 years between 1 January 2005 and 31 December 2017. Clinical data were obtained from patient records and longer‐term outcomes via parent survey at least 1 year after initial infection.ResultsForty‐three children were identified over the 13‐year period, 17 (39.5%) neonates and 26 (60.4%) non‐neonates. The annual incidence for HSV CNS infection in Queensland children aged ≤16 years was 0.3/100 000 (95% confidence intervals (CIs): 0.2–0.4) with neonates at highest risk (incidence 2.5/100 000 live births, 95% CI: 1.5–3.9). HSV 1 was the predominant serotype in both neonates and non‐neonates (9/17, 52.9% neonates and 19/26, 73.1% non‐neonates). Seven (16.3%) children died, five (5/17, 29.4% neonates), directly attributable to HSV CNS infection (all neonates). Twenty‐five (58.1%) had neurological morbidity at discharge (9/17 neonates (52.9%) vs. 16/26 (61.5%) non‐neonates) and 20/27 (74.1%) reported long‐term neurological morbidity at follow‐up (5/9 neonates (55.6%) vs. 15/18 non‐neonates (83.3%)). Seven children (two neonates and four non‐neonates) with long‐term neurological sequelae had no neurological morbidity identified at discharge.ConclusionSignificant long‐term neurologic sequelae were seen in children with HSV CNS infection even in children with no neurological disability identified at discharge from hospital. Careful neurodevelopmental follow‐up of all children is recommended.
Point prevalence and clinical course of proteinuria in dogs with idiopathic non‐erosive immune‐mediated polyarthritis
Authors: Barker L. , McManus S. , Adamantos S. , Black V. 
Published: May 2022

ObjectivesTo describe the point prevalence and clinical course of proteinuria in dogs diagnosed with idiopathic non‐erosive immune‐mediated polyarthritis.Materials and MethodsCases presenting to a single referral centre with a diagnosis of idiopathic non‐erosive immune‐mediated polyarthritis were retrospectively recruited from January 2009 to August 2018. Data including signalment, urinalysis, clinicopathological results, cytology from arthrocentesis, treatment and long‐term follow‐up were analysed. Dogs were defined as: non‐proteinuric (UPC <0.2), borderline proteinuric (UPC 0.2‐0.5) or overtly proteinuric (UPC >0.5).ResultsFifty‐eight dogs met the inclusion criteria. Twenty‐two dogs were overtly proteinuric (38%), eight dogs were borderline proteinuric (14%) and 28 dogs were non‐proteinuric (48%). Repeated urinalysis was performed in nine of 12 dogs with UPC greater than 2.0. The UPC decreased in all nine dogs, with the UPC decreasing to less than 0.5 in 44% of dogs. A greater than 50% decrease in UPC was noted in 44% of dogs, despite seven of nine (77%) receiving prednisolone as either monotherapy or in conjunction with an adjunctive immunosuppressive medication.Clinical SignificanceProteinuria was common in this cohort of dogs diagnosed with primary idiopathic non‐erosive immune‐mediated polyarthritis. The use of prednisolone does not appear to be contraindicated in proteinuric dogs with idiopathic non‐erosive immune‐mediated polyarthritis.
Artificial weathering of an ordinary chondrite: Recommendations for the curation of Antarctic meteorites
Authors: van Ginneken Matthias , Debaille Vinciane , Decrée Sophie , Goderis Steven , Woodland Alan B. , Wozniakiewicz Penelope , De Ceukelaire Marleen , Leduc Thierry , Claeys Philippe 
Published: May 2022

AbstractMeteorites are prone to errestrial weathering not only after their fall on the Earth’s surface but also during storage in museum collections. To study the susceptibility of this material to weathering, weathering experiments were carried out on polished sections of the H5 chondrite Asuka 10177. The experiments consisted of four 100‐days cycles during which temperature and humidity varied on a twelve hours basis. The first alteration cycle consisted of changing the temperature from 15 to 25 °C; the second cycle consisted of modifying both humidity and temperature from 35 to 45% and 15 to 25 °C, respectively; the third cycle consisted of varying the humidity level from 40 to 60%; and the fourth cycle maintained a fixed high humidity of 80%. Weathering products resulting from the experiments were identified and characterized using scanning electron microscopy–energy dispersive spectroscopy and Raman spectroscopy. Such products were not observed at the microscopic scale after the first cycle of alteration. Conversely, products typical of the corrosion of meteoritic FeNi metal were observed during scanning electron microscope surveys after all subsequent cycles. Important increases in the distribution of weathering products on the samples were observed after cycles 2 and 4 but not after cycle 3, suggesting that the combination of temperature and humidity fluctuations or high humidity (>60%) alone is most detrimental to chondritic samples. Chemistry of the weathering products revealed a high degree of FeNi metal corrosion with a limited contribution of troilite corrosion. No clear evidence of mafic silicate alteration was observed after all cycles, suggesting that postretrieval alteration remains limited to FeNi metal and to a lesser extent to troilite.
Assessing the impact of a statewide effort to improve breastfeeding rates: A RE‐AIM evaluation of CHAMPS in Mississippi
Authors: Merewood Anne , Burnham Laura , Berger Jacqueline , Gambari Aishat , Safon Cara , Beliveau Paige , Logan‐Hurt Tawanda , Nickel Nathan 
Published: May 2022

AbstractCommunities and Hospitals Advancing Maternity Practices (CHAMPS) is a public health initiative, operating in Mississippi since 2014, to improve maternal and child health practices and reduce racial disparities in breastfeeding. Using the Reach, Effectiveness, Adoption, Implementation and Maintenance framework, this study assessed CHAMPS, which used a Quality Improvement intervention at hospitals, and engaged intensively with local community partners. The study team assessed outcomes through quantitative data (2014–2020) from national sources, Mississippi hospitals, community partners and CHAMPS programme records, and qualitative data from focus groups. With 95% of eligible Mississippi hospitals enrolled into CHAMPS, the programme reached 98% of eligible birthing women in Mississippi, and 65% of breastfeeding peer counsellors in Mississippi's Special Supplemental Nutrition Programme for Women, Infants and Children. Average hospital breastfeeding initiation rates rose from 56% to 66% (p < 0.05), the proportion of hospitals designated Baby‐Friendly or attaining the final stages thereof rose from 15% to 90%, and 80% of Mississippi Special Supplemental Programme for Women, Infants, and Children districts engaged with CHAMPS. CHAMPS also maintains a funded presence in Mississippi, and all designated hospitals have maintained Baby‐Friendly status. These findings show that a breastfeeding‐focused public health initiative using broad‐based strategic programming involving multiple stakeholders and a range of evaluation criteria can be successful. More breastfeeding promotion and support programmes should assess their wider impact using evidence‐based implementation frameworks.
Signatures of selection in core and accessory genomes indicate different ecological drivers of diversification among Bacillus cereus clades
Authors: White Hugh , Vos Michiel , Sheppard Samuel K. , Pascoe Ben , Raymond Ben 
Published: May 2022

AbstractBacterial clades are often ecologically distinct, despite extensive horizontal gene transfer (HGT). How selection works on different parts of bacterial pan‐genomes to drive and maintain the emergence of clades is unclear. Focusing on the three largest clades in the diverse and well‐studied Bacillus cereus sensu lato group, we identified clade‐specific core genes (present in all clade members) and then used clade‐specific allelic diversity to identify genes under purifying and diversifying selection. Clade‐specific accessory genes (present in a subset of strains within a clade) were characterized as being under selection using presence/absence in specific clades. Gene ontology analyses of genes under selection revealed that different gene functions were enriched in different clades. Furthermore, some gene functions were enriched only amongst clade‐specific core or accessory genomes. Genes under purifying selection were often clade‐specific, while genes under diversifying selection showed signs of frequent HGT. These patterns are consistent with different selection pressures acting on both the core and the accessory genomes of different clades and can lead to ecological divergence in both cases. Examining variation in allelic diversity allows us to uncover genes under clade‐specific selection, allowing ready identification of strains and their ecological niche.
Plant growth‐promoting rhizobacterium Pseudomonas sp. CM11 specifically induces lateral roots
Authors: Li Qian , Li Huchen , Yang Zhuang , Cheng Xu , Zhao Yaceng , Qin Ling , Bisseling Ton , Cao Qingqin , Willemsen Viola 
Published: May 2022

Summary

Plant growth‐promoting rhizobacteria are involved in altering secondary root (SR) formation, but hitherto there has been no distinction between the different types of SRs upon induction of soil biota, and the genetic pathways involved.

By using plate and soil systems, we studied the effects of the Pseudomonas strains CM11 and WCS417 on plant performance with a focus on root development. Through a combination of cellular, molecular and genetic analyses, we investigated the type of SRs induced upon CM11 and WCS417 root inoculation using genetic pathways associated with specific SR types.

CM11 was shown to affect the root architecture differently from WCS417. CM11 inoculation leads to primary root arrest, whereas WCS417 reveals a longer primary root. Both CM11 and WCS417 activate the PLETHORA 3,5,7‐controlled lateral root pathway, rather than the WUSCHEL‐RELATED HOMEOBOX 11,12‐controlled adventitious (lateral) root pathway. In addition, CM11 promotes plant growth in model and various crop species. It improves plant fitness traits, such as bigger shoots, faster bolting and higher yield in terms of seeds.

Our results indicate that the root system architecture can be promoted by activation of PLETHORA 3,5,7 dependent primed lateral pre‐branch sites upon inoculation with CM11, which creates great potential to gain a better understanding of root plasticity.
Broad‐range metalloprotease profiling in plants uncovers immunity provided by defence‐related metalloenzyme
Authors: Morimoto Kyoko , Krahn Daniel , Kaschani Farnusch , Hopkinson‐Woolley Digby , Gee Anna , Buscaill Pierre , Mohammed Shabaz , Sieber Stephan A. , Cravatt Benjamin F. , Schofield Christopher J. , van der Hoorn Renier A. L. 
Published: May 2022

Summary

Plants encode > 100 metalloproteases representing > 19 different protein families. Tools to study this large and diverse class of proteases have not yet been introduced into plant research.

We describe the use of hydroxamate‐based photoaffinity probes to explore plant proteomes for metalloproteases.

We detected labelling of 23 metalloproteases in leaf extracts of the model plant Arabidopsis thaliana that belong to nine different metalloprotease families and localize to different subcellular compartments. The probes identified several chloroplastic FtsH proteases, vacuolar aspartyl aminopeptidase DAP1, peroxisomal metalloprotease PMX16, extracellular matrix metalloproteases and many cytosolic metalloproteases. We also identified nonproteolytic metallohydrolases involved in the release of auxin and in the urea cycle. Studies on tobacco plants (Nicotiana benthamiana) infected with the bacterial plant pathogen Pseudomonas syringae uncovered the induced labelling of PRp27, a secreted protein with implicated metalloprotease activity. PRp27 overexpression increases resistance, and PRp27 mutants lacking metal binding site are no longer labelled, but still show increased immunity.

Collectively, these studies reveal the power of broad‐range metalloprotease profiling in plants using hydroxamate‐based probes.