bluuebunny/crossref_metadata_2025_split huggingface dataset:
Translation, cross-cultural adaptation, and validation of the Athlete Fear Avoidance Questionnaire (AFAQ) into Brazilian Portuguese
Authors: dos Reis-Junior Jodimar Ribeiro , Bassi-Dibai Daniela , Morais Daniel Nunes , Pontes-Silva André , Mendes Letícia Padilha , Pinheiro Jocassia Silva , Fidelis-de-Paula-Gomes Cid André , Dibai-Filho Almir Vieira 
Published: November 2022

Abstract
Background
Psychological factors play an important role in the adequate return of an athlete to sport. Our aim was to perform the translation, cross-cultural adaptation, and validation of the Athlete Fear Avoidance Questionnaire (AFAQ) into Brazilian Portuguese.

Methods
We performed the translation and cross-cultural adaptation and evaluated the structural validity, construct validity, and test–retest reliability. In addition to the AFAQ, we used the Numerical Pain Scale (NPS), Pain-Related Catastrophizing Thoughts Scale (PCTS), Self-Estimated Functional Inability because of Pain Questionnaire for athletes (SEFIP-sport), and Hospital Anxiety and Depression Scale (HADS). We used the exploratory factor analysis (EFA) to analyze the internal structure of the AFAQ. We used the Spearman’s correlation coefficient (rho) to determine the magnitude of correlation between the AFAQ and the other instruments. We evaluated the test–retest reliability and internal consistency by means of intraclass correlation coefficient (ICC) and Cronbach’s alpha, respectively.

Results
No adaptation was necessary to produce the AFAQ version in Brazilian Portuguese. We included 160 participants in the study. We identified the one-dimensionality of the AFAQ through the EFA with the implementation of parallel analysis (KMO = 0.83, p < 0.001 in Bartlett's Sphericity test). In construct validity, the magnitudes of correlation between the AFAQ and the other instruments ranged from 0.257 to 0.548. We identified adequate reliability (ICC = 0.85) and internal consistency (Cronbach’s alpha = 0.90).

Conclusion
The Brazilian version of the AFAQ with one domain and 10 items has adequate measurement properties in injured professional and recreational athletes.
Folk nomenclature and traditional knowledge of breadfruit [Artocarpus altilis (Parkinson) Fosberg] diversity in four Anglophone Caribbean countries
Authors: Daley Oral O. , Roberts-Nkrumah Laura B. , Alleyne Angela T. , Gloster Michael C. 
Published: November 2022

AbstractBackgroundSince its introduction to the Anglophone Caribbean in 1793, breadfruit has had a diverse history in the region, and there is a considerable repository of traditional knowledge about the crop, that is undocumented. Consequently, it remains underutilized as a food source, despite recognition of its potential to contribute to food and nutrition security. Understanding the folk taxonomy and traditional knowledge associated with its diversity and uses is a prerequisite to develop programs for its commercial production and utilization.MethodThis study was conducted among 170 respondents who were selected across four Anglophone Caribbean countries and provided information on the ethnobotany and traditional knowledge associated with breadfruit biodiversity, including systems of naming, identification and classification of breadfruit cultivars or types.ResultsBreadfruit has socio-cultural and economic value and is produced for both home use and sale by most respondents (68%). The genetic diversity of breadfruit managed by the respondents is also important, as a total of 51 vernacular names were identified, with nine of those names recorded for the first time in this study. Breadfruit types were identified by morphological and agronomical characteristics, with other important traits relating to use and cooking quality. Classification of breadfruit cultivars or types was based on eating-quality, most suitable methods of preparation and ease of cooking.ConclusionThe ethnobotanical and traditional knowledge obtained from this study may be useful in assessing the genetic diversity of breadfruit and guiding future community-based conservation and classification studies of this important crop resource in the Caribbean. This is crucial to support the commercialization of breadfruit to improve its contribution to food and nutrition security.
Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Cas9
Authors: Zhang Yang , He Fei , Zhang Yanning , Dai Qian , Li Qintong , Nan Jing , Miao Ruidong , Cheng Bo 
Published: November 2022

Abstract
Background
Krüppel Associated Box-containing Zinc Finger Proteins (KRAB-ZFPs), representing the largest superfamily of transcription factors in mammals, are predicted to primarily target and repress transposable elements (TEs). It is challenging to dissect the distinct functions of these transcription regulators due to their sequence similarity and diversity, and also the complicated repetitiveness of their targeting TE sequences.

Results
Mouse KRAB-Zfps are mainly organized into clusters genomewide. In this study, we revealed that the intra-cluster members had a close evolutionary relationship, and a similar preference for zinc finger (ZnF) usage. KRAB-Zfps were expressed in a cell type- or tissue type specific manner and they tended to be actively transcribed together with other cluster members. Further sequence analyses pointed out the linker sequences in between ZnFs were conserved, and meanwhile had distinct cluster specificity. Based on these unique characteristics of KRAB-Zfp clusters, sgRNAs were designed to edit cluster-specific linkers to abolish the functions of the targeted cluster(s). Using mouse embryonic stem cells (mESC) as a model, we screened and obtained a series of sgRNAs targeting various highly expressed KRAB-Zfp clusters. The effectiveness of sgRNAs were verified in a reporter assay exclusively developed for multi-target sgRNAs and further confirmed by PCR-based analyses. Using mESC cell lines inducibly expressing Cas9 and these sgRNAs, we found that editing different KRAB-Zfp clusters resulted in the transcriptional changes of distinct categories of TEs.

Conclusions
Collectively, the intrinsic sequence correlations of intra-cluster KRAB-Zfp members discovered in this study suggest that the conserved cluster specific linkers played crucial roles in diversifying the tandem ZnF array and the related target specificity of KRAB-Zfps during clusters’ evolution. On this basis, an effective CRISPR-Cas9 based approach against the linker sequences is developed and verified for rapidly editing KRAB-Zfp clusters to identify the regulatory correlation between the cluster members and their potential TE targets.
Jejunal obstruction due to jejunocolic congenital band in a 12-year-old child: a case report
Authors: Maree Gulan , Alelayan Ali , Hemi Ferhad , Shater Waseem , Ghuzlan Alaa , Ali Wajih 
Published: November 2022

Abstract
Background
A congenital band is an uncommon abnormality that can be found anywhere along the gastrointestinal tract. Intestinal obstruction caused by an anomalous congenital band is very rare in children. To the best of our knowledge, no cases of congenital bands extending from the descending colon to the jejunum have been reported in the English literature

Case presentation
Herein, we present the case of a 12-year-old Syrian patient with intestinal obstruction due to a congenital band extending from the mesentery of the descending colon to the mesentery of the jejunum with an entrapped loop of jejunum between the band and the mesentery. The location of the obstruction was determined by upper gastrointestinal contrast radiography, but the cause of the obstruction was diagnosed intraoperatively. The band was excised without intestinal resection.

Conclusion
Prediagnosis of congenital bands can be challenging, and surgery is required. When making a bowel obstruction differential diagnosis, it is important to keep this type of band in mind.
Competition and quality of care under regulated fees: evidence from Ghana
Authors: Dzampe Adolf Kwadzo , Takahashi Shingo 
Published: November 2022

Abstract
Background
How competition affects the quality of care is still not well understood empirically because of limited and mixed results. This study examined whether competition leads to higher or lower quality health outcomes in Ghana.

Methods
We used administrative claims data of hypertension patients for 2017 – 2019 (36 months), and an instrumental variable method to examine the effect of competition, measured as an increase in district doctor-to-population ratio on hospital-level ambulatory care sensitive condition hospitalization and in-hospital death rates.

Results
Overall, we found that an increase in doctor density improves the quality of care for hypertension patients in Ghana. That is, when there are more doctors, fewer patients are hospitalized, and the risk of in-hospital deaths decreases. This result is robust to analyses at the individual and district population levels for ambulatory care sensitive hospitalizations rate.

Conclusions
Our findings suggest that in the presence of physician-induced demand, competition can lead to improvement in the quality of care, possibly through improved access to healthcare and increased physician time and contact per patient. Future health policies need to consider possible welfare benefits of induced medical services and training more doctors.
The importance of critically short telomere in myelodysplastic syndrome
Authors: Shin Dong-Yeop , Lim Kyu Min , Park Hee Sue , Kwon Sunghoon , Yoon Sung-Soo , Lee Dong-Soon 
Published: November 2022

AbstractA few critically short telomeres trigger genomic instability regardless of average telomere length (TL). Recently, the telomere shortest length assay (TeSLA) was developed to detect critically short telomeres and measure absolute telomeres. Using TeSLA with the internally labeled biotin probe, we measured the TL of bone marrow (BM) aspirates from 52 patients with myelodysplastic syndrome (MDS). A percentage of shortest telomeres (< 1.0 kb (ShTL1.0)) were calculated. ShTL1.0 was correlated to IPSS-R risk (spearman’s rho = 0.35 and p = 0.0196), and ShTL1.0 and BM blast (2.61% in < 5% blast, 4.15% in 5–10% blast, and 6.80% in 10–20% blast, respectively, p = 0.0332). Interestingly, MDS patients with a shortest TL ≥ 0.787 kb at the time of diagnosis showed better overall survival (OS) and progression-free survival (PFS) than patients with a shortest TL < 0.787 kb in the multivariate analyses (HR = 0.13 and 0.30, p = 0.011 and 0.048 for OS and PFS, respectively). Our results clearly show the presence and abundance of critically short telomeres in MDS patients. These pathologic telomeres are associated with IPSS-R which is a validated prognostic scoring system in MDS. Furthermore, they are independent prognostic factors for OS in MDS patients. Future prospective studies are needed to validate our results.
Experience and social factors influence movement and habitat selection in scimitar-horned oryx (Oryx dammah) reintroduced into Chad
Authors: Majaliwa M. M. , Hughey L. F. , Stabach J. A. , Songer M. , Whyle K. , Alhashmi A. E. A. , Al Remeithi M. , Pusey R. , Chaibo H. A. , Ngari Walsoumon A. , Hassan Hatcha M. , Wacher T. , Ngaba C. , Newby J. , Leimgruber P. , Mertes K. 
Published: November 2022

AbstractReintroduced animals—especially those raised in captivity—are faced with the unique challenge of navigating a wholly unfamiliar environment, and often make erratic or extensive movements after release. Naïveté to the reintroduction landscape can be costly, e.g., through increased energy expenditure, greater exposure to predation, and reduced opportunities to forage. Integration with an extant population may provide opportunities for social information transfer. However, in the absence of interactions with residents, it is unclear how individual and social learning may affect an animal’s ability to track resources in an unfamiliar landscape. We use integrated step selection functions (iSSFs) to address these knowledge gaps, by evaluating the extent to which environmental factors, individual experience (time since release), and social information-sharing (group size) influence movement decisions by scimitar-horned oryx (Oryx dammah) reintroduced into their native range for the first time in ca. 30 years. We found that both experience and social factors influenced the habitat selection and movement behavior of reintroduced oryx. Of four candidate iSSFs, the model that included environmental, experience, and group size variables performed best in both dry and wet periods. Statistically significant interaction terms between environmental variables and experience were generally larger than similar terms for group size, indicating that experience may affect habitat selection by reintroduced oryx more strongly than social factors. These findings may inform the management of recovering wildlife populations, update widely-held expectations about how released ungulates acclimate to novel landscapes, and demonstrate the utility of long-term monitoring of reintroduced populations.
The Women’s Health Initiative cancer survivorship clinic incorporating electronic patient-reported outcomes: a study protocol for the Linking You to Support and Advice (LYSA) randomized controlled trial
Authors: Kearns Noreen , Raigal-Aran Laia , O’Connell Kate , Davis Andrea , Bermingham Katie , O’Reilly Seamus , Collins Dearbhaile C. , Corrigan Mark , Coulter John , Cleary Vicki , Cushen Samantha , Flavin Aileen , Byrne Fiona , O’Grady Aisling , O’Neill Deirdre , Murphy Aileen , Dahly Darren , Palmer Brendan , Connolly Roisin M. , Hegarty Josephine 
Published: November 2022

Abstract
Background
The improved survival rate for many cancers in high-income countries demands a coordinated multidisciplinary approach to survivorship care and service provision to ensure optimal patient outcomes and quality of life. This study assesses the feasibility of introducing a Women’s Health Initiative cancer survivorship clinic in Ireland.

Methods
The trial comprises an intervention and control arm. Two hundred participants will be recruited. Key eligibility (1) women with early-stage hormone receptor-positive breast or gynecologic cancer (cervix or endometrial), within 12 months of completion of primary curative therapy, and (2) access to the Internet.
The complex intervention comprises a nurse-led clinic targeting symptom management through a trigger alert system, utilizing electronic patient-reported outcome (ePRO) assessments at baseline, and 2, 4, 6, 8, 10, and 12 months. It also includes input from a dietitian monitoring diet and nutritional status.
The control group will receive their usual care pathway standard of care and attend the cancer survivorship clinic and complete ePRO assessments at the start and end of the study.
The primary endpoint (feasibility) includes the proportion of enrolled participants who complete baseline and follow-up ePRO surveys and partake in health professional consultations after ePRO data triggers. Secondary endpoints include changes in cancer-related symptom scores assessed by ePROs, health-related Quality of Life Questionnaire (QLQ) scores, Appraisal Self-Care Agency-R scores, and adjuvant endocrine therapy medication adherence. A process evaluation will capture the experiences of participation in the study, and the healthcare costs will be examined as part of the economic analysis.
Ethical approval was granted in December 2020, with accrual commencing in March 2021.

Discussion
This protocol describes the implementation of a parallel arm randomized controlled trial (RCT) which examines the feasibility of delivering a Cancer Survivorship Clinic. The ePRO is an innovative symptom monitoring system which detects the treatment-related effects and provides individualized support for cancer survivors. The findings will provide direction for the implementation of future survivorship care.

Trial registration
ClinicalTrials.gov, NCT05035173. Retrospectively registered on September 5, 2021
Euthanasia of a person with a psychiatric disorder does not violate the European Convention on Human Rights (Mortier v. Belgium [no. 78017/17])
Authors: De Hert M. , Loos S. , Van Assche K. 
Published: November 2022

For more than 20 years, euthanasia in Belgium and The Netherlands is allowed for unbearable suffering caused by terminal or non-terminal illnesses, including psychiatric disorders. Although euthanasia numbers have been increasing over the years, the percentage of cases involving people with a primary psychiatric diagnosis has remained stable (between 1 and 2%). For these cases, the Belgian and Dutch Euthanasia Laws operate similar due care criteria: a well-considered, repeated, and voluntary request from a legally competent adult; a medical condition without prospect of improvement; constant and unbearable suffering that cannot be alleviated; consultation of two independent physicians, including a psychiatrist; and a posteriori evaluation and control [1–3].
Effects of a Geriatric Assessment Intervention on Patient-Reported Symptomatic Toxicity in Older Adults With Advanced Cancer
Authors: Culakova Eva , Mohile Supriya G. , Peppone Luke , Ramsdale Erika , Mohamed Mostafa , Xu Huiwen , Wells Megan , Tylock Rachael , Java Jim , Loh Kah Poh , Magnuson Allison , Jamieson Leah , Vogel Victor , Duberstein Paul R. , Chapman Benjamin P. , Dale William , Flannery Marie Anne 
Published: November 2022

PURPOSE Providing a geriatric assessment (GA) summary with management recommendations to oncologists reduces clinician-rated toxicity in older patients with advanced cancer receiving treatment. This secondary analysis of a national cluster randomized clinical trial (ClinicalTrials.gov identifier: NCT02054741 ) aims to assess the effects of a GA intervention on symptomatic toxicity measured by Patient-Reported Outcomes Common Terminology Criteria for Adverse Events (PRO-CTCAE). METHODS From 2014 to 2019, the study enrolled patients age ≥ 70 years, with advanced solid tumors or lymphoma and ≥ 1 GA domain impairment, who were initiating a regimen with high prevalence of toxicity. Patients completed PRO-CTCAEs, including the severity of 24 symptoms (11 classified as core symptoms) at enrollment, 4-6 weeks, 3 months, and 6 months. Symptoms were scored as grade ≥ 2 (at least moderate) and grade ≥ 3 (severe/very severe). Symptomatic toxicity was determined by an increase in severity during treatment. A generalized estimating equation model was used to assess the effects of the GA intervention on symptomatic toxicity. RESULTS Mean age was 77 years (range, 70-96 years), 43% were female, and 88% were White, 59% had GI or lung cancers, and 27% received prior chemotherapy. In 706 patients who provided PRO-CTCAEs at baseline, 86.1% reported at least one moderate symptom and 49.7% reported severe/very severe symptoms at regimen initiation. In 623 patients with follow-up PRO-CTCAE data, compared with usual care, fewer patients in the GA intervention arm reported grade ≥ 2 symptomatic toxicity (overall: 88.9% v 94.8%, P = .035; core symptoms: 83.4% v 91.7%, P = .001). The results for grade ≥ 3 toxicity were comparable but not significant ( P > .05). CONCLUSION In the presence of a high baseline symptom burden, a GA intervention for older patients with advanced cancer reduces patient-reported symptomatic toxicity.
Development of an adenosquamous carcinoma histopathology – selective lung metastasis model
Authors: Lähdeniemi Iris A. K. , Devlin Jennifer R. , Nagaraj Ashwini S. , Talwelkar Sarang S. , Bao Jie , Linnavirta Nora , Şeref Vujaklija Ceren , Kiss Elina A. , Hemmes Annabrita , Verschuren Emmy W. 
Published: November 2022

ABSTRACT
Preclinical tumor models with native tissue microenvironments provide essential tools to understand how heterogeneous tumor phenotypes relate to drug response. Here we present syngeneic graft models of aggressive, metastasis-prone histopathology-specific NSCLC tumor types driven by KRAS mutation and loss of LKB1 (KL): adenosquamous carcinoma (ASC) and adenocarcinoma (AC). We show that subcutaneous injection of primary KL; ASC cells results in squamous cell carcinoma (SCC) tumors with high levels of stromal infiltrates, lacking the source heterogeneous histotype. Despite forming subcutaneous tumors, intravenously injected KL;AC cells were unable to form lung tumors. In contrast, intravenous injection of KL;ASC cells leads to their lung re-colonization and lesions recapitulating the mixed AC and SCC histopathology, tumor immune suppressive microenvironment and oncogenic signaling profile of source tumors, demonstrating histopathology-selective phenotypic dominance over genetic drivers. Pan-ERBB inhibition increased survival, while selective ERBB1/EGFR inhibition did not, suggesting a role of the ERBB network crosstalk in resistance to ERBB1/EGFR. This immunocompetent NSCLC lung colonization model hence phenocopies key properties of the metastasis-prone ASC histopathology, and serves as a preclinical model to dissect therapy responses and metastasis-associated processes.
Interactions between asthma and the COVID-19 pandemic
Authors: Iwaniszyn-Zapołoch Klara , Małek Anna , Wysokińska Olga , Zadrożna Karolina , Cholewa Krystian , Żyga Justyna 
Published: November 2022

ABSTRACT
Introduction: The COVID-19 pandemic has been accompanying us in our daily lives for more than 2.5 years and so far there are no indications that it will leave us soon. Updating information and knowledge about it is therefore still incredibly important. Sars-CoV-2 is a virus with a high affinity for the respiratory system, so it is worth tracing its correlations with one of the more common lung diseases, asthma. Patients with this disease are concerned about whether they are at risk of contracting COVID-19 more frequently and severely, whether they face a higher risk of death if infected and how the pandemic will affect exacerbations of their underlying disease. For physicians who encounter the virus on a daily basis, it is important to know how well to manage asthmatic patients if COVID-19 is confirmed in them.
State of knowledge: In medicine, not everything is clear-cut. Much depends on our patient's age, condition and other comorbidities. And also on his/her adherence to medical advice, type and degree of asthma control. In this article, we will address all these aspects and summarise the current knowledge on the interplay between COVID-19 and asthma.
Conclusions: With the review of recent reports collected here, it can be thought that asthma is not an independent factor for either a higher frequency or severity of COVID-19, but neither does it affect the higher risk of death with Sars-CoV-2 infection. In terms of treatment, it is important not to interrupt the current therapy and to maintain good asthma control. This is the most optimal treatment and reduces the risk of severe COVID-19. Drugs registered for the treatment of asthma are safe and, moreover, it has been suggested that corticosteroids protect against infection to some extent.