bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depression links with the non-motor symptoms of Parkinson’s disease
Authors: Mayeli Mahsa , Shafie Mahan , Shiravi Maryam , Mirsepassi Zahra , Rahiminejad Fatemeh , Sattarpour Reza , Aghamollaii Vajiheh 
Published: July 2022

Abstract
Background: The non-motor symptoms (NMS) of Parkinson’s disease (PD) and their potential role in early diagnosis are recent debates. Herein, we aimed to investigate the association between depression and non-motor symptoms of PD including sleep disorders, hyposexuality, hyposmia, constipation, and orthostatic hypotension. Methods: After obtaining written informed consent, the diagnosis was confirmed using the criteria developed by the United Kingdom PD Society Brain Bank for the clinical diagnosis of PD. The stage and the severity of the disease were determined using the UPDRS and Hoehn & Yahr criteria. Demographics as well as the family history, habitual history, and past medical history data were obtained. Depression was determined through a psychiatric consultation based on DSMV criteria and Beck Depression Inventory (BDI). Sleep quality was assessed using the Pittsburgh Sleep Quality (PSQ), and Epworth and REM Sleep Behavior Disorder Sleep Questionnaire (RBDSQ) was applied to investigate daytime sleepiness and REM sleep disorders, respectively. Cognitive disorders were also investigated using Montreal cognitive assessment (MoCA).Results: 93 patients were enrolled. The BDI score was significantly correlated with hyposexuality, MoCA scores, and PSQ scores. Depression was significantly more severe in those with hyposexuality (p-value = 0.018). After adjustments, a significant association existed between the BDI score and the MoCA score and hyposexuality.Conclusions: Besides the known correlations of depression with cognitive decline in PD, depression is also significantly associated with hyposexuality in these patients. The etiological underpinnings of these associations are to be explored in the future.
DoS Attack on SDN: a study on control plane strategies in-band and out-of-band
Authors: Neves Rafael H. , Silva Anderson. A. A. , Gava Vagner , Azevedo Marcelo T. , Sandoval Jonathan F. R. , Oliveira Fabio S. , Guelfi Adilson E. , Kofuji Sergio T. 
Published: July 2022

Abstract
A Software Defined Network (SDN) assumes a centralized control plane independent of the data planes of the network elements. This central-ization in itself represents a relevant aspect concerning SDN security, which, added to its operation of reactive nature, can represent an opportunity to carry out denial of service attacks. In turn, the SDN control plane can be implemented in two ways: (1) in-band and (2) out-of-band. An out-of-band control plane adopts a separate exclusive network for control communication, consequently increasing implementation costs. On the other hand, an in-band control plane has a lower implementation cost, but it demands sharing the physical medium between data communication and control communication. This work’s purpose is to study the impact of a denial of service attack directed at an SDN from the optic of implementing the control plane: (1) in-band and (2) out-of-band. Subsequently, the form of implementation 1 Springer Nature 2021 L A T E X template DoS Attack on SDN: a study on control plane strategies in-band and out-of-band of the SDN control plane is reviewed to determine if it influences the behavior of the network, given the scenarios established for this work.
Application of PCT, CRP and white blood cell count for the rapid diagnosis of Clostridium difficile in patients with IBD
Authors: Xie Shuhua , Wu Zhongwen , Chen Peisong , Wang Dong , Liao Kang , Liu Min , Zhang Shihong , Chen Yili 
Published: July 2022

Abstract
Background
The incidence of Clostridium difficile infection (CDI) has increased in recent years in patients with inflammatory bowel disease (IBD). C. difficile is a toxin-producing bacterium, and CDI results in the worsening of the underlying IBD, increasing the risks of IBD treatment failure, surgery and hospitalization. Since the symptoms of CDI overlap with those of IBD, it is challenging to make a differential diagnosis. Therefore, early, rapid and reliable diagnostic tools that can identify CDI in IBD patients would be valuable to clinicians.
Methods
This study enrolled 135 patients with IBD. Among them, 44 patients were diagnosed with CDI, and 42 patients were diagnosed with viral or fungal infections; 49 patients without infections were enrolled in the control group. The diagnostic values of procalcitonin (PCT), C-reactive protein (CRP) and the white blood cell count (WBC) in the peripheral blood were examined. A receiver operating characteristic (ROC) curve was used to analyse the diagnostic value of these parameters.
Results
In this study, the PCT and CRP levels were significantly higher in patients with CDI than in non-CDI patients (including patients with viral/fungal infections and the control group; p < 0.001 and p < 0.05, respectively). In the ROC curve analysis of the IBD-CDI group and the control group, PCT and CRP predicted IBD-CDI with an area under the curve (AUC) of 0.826 [95% confidence interval (CI) 0.743–0.909, p = 0.000] and 0.663 [95% confidence interval (CI) 0.551–0.774, p = 0.007], respectively. The WBC count was inferior as diagnostic tool for CDI. The sensitivity was 56.82% (95% CI: 41.03–71.65%), the specificity was 91.84% (95% CI: 80.40–97.73%), and the LR (+) was 6.96 for PCT for the diagnosis of CDI.
Conclusions
The present study demonstrated the superiority of PCT over CRP and the WBC for the rapid diagnosis of CDI in IBD patients. Additionally, PCT can be used to predict the clinical outcomes.
The burden of BRCA1 and BRCA2 gene mutations among Vietnamese women and their associated factors: a protocol for a systematic review and meta-analysis
Authors: Tran Phuc , Tran Duc , Vu Chi , Phan Quang , Nguyen Anh 
Published: July 2022

Abstract

IntroductionBRCA1 and BRCA2 (also known as BRCA) mutation carriers are now frequently provided genetic counselling. A precise estimation of the prevalence of BRCA gene mutations is essential for the counsellor to provide an appropriate risk prediction. However, these data on Vietnamese women and their associated factors will be explored and confirmed further. The objective of this protocol is to provide a new systematic review with meta-analysis using the present methodology to reveal these hitherto unknown data.Methods and AnalysisPRISMA-P, a set of criteria for conducting systematic reviews, was followed in developing and reporting this protocol. From the databases' inception, a comprehensive search will be undertaken in electronic PubMed and Scopus databases. In two stages, title/abstract screening and full-text screening, two independent authors will assess all retrieved articles for inclusion. This review includes papers providing the relevant results reflecting the prevalence of BRCA gene mutations in Vietnamese women at least 18 years old and with or without cancer. Predefined selection criteria will be used to establish each publication's eligibility. Using the Newcastle-Ottawa Scale and Cochrane Risk of Bias tools, the quality of included studies will be assessed, and overall evidence quality will be appraised using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Initially, all pertinent data from the included articles will be entered into an online MS Excel spreadsheet for meta-analysis. Then it will be imported into Rstudio software. Meta-analyses using random effects will be used to obtain the pooled percentages. The chi-squared test and the I2 parameter will be used to evaluate heterogeneity. Publication bias will be investigated visually using funnel plots for asymmetry and Egger's statistical tests.Ethics and DisseminationNot applicable.Systematic review registrationPROSPERO CRD42022340152 (Registered status)
Clinical T2N0 rectal cancer treated with neoadjuvant chemoradiotherapy plus local excision
Authors: Suzuki Toshiyuki , Sadahiro Sotaro , Okada Kazutake , Miyakita Hiroshi , Ogimi Takeshi , Chan Lin Fung , Kamei Yutaro , Yamamoto Seiichiro 
Published: July 2022

Abstract
Aim: Total mesorectal excision is the standard treatment for clinical T2 (cT2) rectal cancer; however, this procedure can result in postoperative dysfunction, decreased quality of life, and stoma creation in some patients. We investigated neoadjuvant chemoradiotherapy (nCRT) plus local excision (LE) as an alternative treatment strategy for patients with cT2N0 rectal cancer.Method: Fifty-six patients with cT2N0M0 rectal cancer (anal verge, ≤8 cm; tumor size, <30 mm; and well or moderately differentiated adenocarcinoma) underwent LE following nCRT. Chemoradiotherapy was administered at 40 or 45 Gy in 20–25 fractions with concurrent oral UFT (tegafur/uracil; 400 mg/m2) or S-1 (tegafur/gimeracil/oteracil; 80 mg/m2).Results: Histologically, the excision margin was negative in all patients, and four patients with ypT3 disease underwent total mesorectal excision. Recurrence was observed in 15 patients (27%); local recurrence in 7 (13%) and distant in 10 (18%). The salvage surgery was possible for the local recurrence group. The 5-year disease-free and overall survival rates were 68.4% and 84.9%, respectively. Although 7 (26%) out of 27 patients with a tumor regression grade (TRG) of 3 or 4 developed local recurrence and 6 (22%) had distant metastasis, 25 patients with a TRG of 1 or 2 did not exhibit local recurrence, and only 1 (4%) experienced distant metastasis.Conclusion: nCRT plus LE may be an alternative treatment for patients with cT2N0 rectal cancer who achieved a TRG of 1 or 2. Additional treatment was required in patients with a TRG of 3 or 4.
Robotic Simultaneous Repair of Rectovesical Fistula with Bladder Neck Contracture after Radical Prostatectomy: Step-by-Step Technique and Outcomes
Authors: Sayegh Aref S. , Riva Anibal La , Perez Laura C. , Medina Luis G. , Poncel Jaime , Ortega David G. , Lizana Maria A. , Forsyth Edward , Sotelo Rene 
Published: July 2022

Abstract
The purpose of this study is to report our experience and outcomes using a novel robotic technique for the simultaneous repair of rectovesical fistula (RVF) with bladder neck contracture (BNC) after radical prostatectomy (RP). Between 2019 and 2021, four consecutive patients who underwent robotic-assisted simultaneous repair of RVF with concurrent BNC after RP were retrospectively reviewed. Baseline characteristics and perioperative outcomes were examined and reported. Complications were graded using the modified Clavien-Dindo classification system and the European Association of Urology Complication Panel Assessment and Recommendations. Four cases with a median age of 68.5 (63.3–72.3) years were treated. Interposition omentum flaps were used in all our cases. One case had perineal urethral mobilization to reach healthy urethral margins and tension-free vesicourethral anastomosis. Surgeries were uneventful, with no intraoperative complications reported. Median operative time, estimated blood loss, and length of hospital stay were 370 (291.3–453) minutes, 255 (175–262.5) mL, and 2.5 (2–3) days, respectively. Median Jackson-Pratt drains, Double-J stents and Foley catheter removal days were 6 (6–10), 38 (32–43), and 30 (27–41) days, respectively. No postoperative complications were reported. The median follow-up time was 13 (6–16) months, and no fistula recurrence was shown. Robotic-assisted repair could represent a feasible and effective approach for the simultaneous repair of RVF with concomitant BNC. Larger studies and treatment standardization are needed to assess the role of minimally invasive surgery in the simultaneous management of RVF with BNC after radical prostatectomy.
The composition and structure of the ubiquitous hydrocarbon contamination on van der Waals materials
Authors: Pálinkás András , Kálvin György , Vancsó Péter , Kandrai Konrád , Szendrő Márton , Németh Gergely , Németh Miklós , Pekker Áron , Pap József S. , Petrik Péter , Kamarás Katalin , Tapaszto Levente , Nemes-Incze Péter 
Published: July 2022

Abstract
The behavior of single layer van der Waals (vdW) materials is profoundly influenced by the immediate atomic environment at their surface, a prime example being the myriad of emergent properties in artificial heterostructures. Equally significant are adsorbates deposited onto their surface from ambient. While vdW interfaces are well understood, our knowledge regarding the atmospheric contamination is severely limited, even after the last decades of intense research in the field. Here we show that the common ambient contamination on the surface of: graphene, graphite, hBN and MoS2 is composed of a self-organized molecular layer, which forms during a few days of ambient exposure. Using low-temperature STM measurements we image the atomic structure of this adlayer and in combination with infrared spectroscopy identify the contaminant molecules as normal alkanes with lengths of 20–26 carbon atoms. Through its ability to self-organize, the alkane layer displaces the manifold other airborne contaminant species, capping the surface of vdW materials and possibly dominating their interaction with the environment.
Oman Strong Motion Network (OSMN) and Site-specific Characterization for the Entire Strong Motion Stations in Muscat Region
Authors: Mohamed A M E , El-Hussain Issa , Deif Ahmed , Al-Shijby Y , Ezzelarab M 
Published: July 2022

Abstract
In 2001, the earthquake monitoring center (EMC) at Sultan Qaboos University (SQU) started monitoring earthquakes that occur in and around the sultanate of Oman through 10 short-period stations. The number of monitoring stations grew to 20 broadband seismic stations between 2004 and 2011 deployed in different parts of the sultanate. In 2014, EMC-SQU began an extensive project for updating and improving the monitoring network by adding 6 broadband stations and establishing a strong motion network consisting of 67 monitoring stations. This provides a good opportunity to investigate the influences of the seismic source, path, and site effects in the ground motion, particularly in the near-source area. Such data are essential for improving seismic hazard maps and consequently seismic building codes and earthquake-resistant design. A wide site selection survey was carried out for the entire proposed stations taking into account the standard site selection criteria. In order to use the strong motion recordings at their full potential, information on the site response at the recording site is needed. So, site investigation at 25 stations in Muscat region was performed in terms of noise level, resonance frequency (using horizontal-to-vertical spectral ratio (HVSR) method), P-wave velocity (using shallow seismic refraction tomography (SRT) technique), and S-wave velocity (using multichannel analysis of surface waves (MASW) tool), in addition to the available geotechnical boreholes. The results reflect the site classification in the light of NEHRP/IBC standards and consequently the seismic hazard level at the ground surface.
WITHDRAWN: Effects of equivalence ratio and wall properties on the heat transfer characteristics of microchannel reactors for hydrogen production
Authors: Chen Junjie 
Published: July 2022

Abstract
There is a continuing effort to perform steam reforming reactions in thermally integrated microchannel chemical reactors. However, the mechanisms for the effects of design factors on heat transfer characteristics are still not fully understood. This study relates to a thermochemical process for producing hydrogen by the catalytic endothermic reaction of methanol with steam in a thermally integrated microchannel reforming reactor. Computational fluid dynamics simulations are conducted to better understand the consumption, generation, and exchange of thermal energy between endothermic and exothermic processes in the reactor. The effects of equivalence ratio and wall properties on heat transfer characteristics and reactor performance are investigated. The results indicate that there are issues of efficiency loss for fuel-rich combustion cases. Loss of flame stability due to external heat losses are main issues that require thermal management. The thermal conductivity of the channel walls is fundamentally important. Materials with high thermal conductivity are preferred for the channel walls. Thermally conductive ceramics and metals are well-suited. Wall materials with poor heat conduction properties degrade the reactor performance. The heat released by the exothermic reaction could be entirely consumed by the endothermic reaction, thereby avoiding heat imbalances within the reactor or reducing the likelihood of the formation of hot spots within the catalyst layers. No flame combustion is involved in the process. Design recommendations are made to improve thermal performance for the reactor.
Female Sexual Function in Different Phenotypes of Polycystic Ovarian Syndrome: A Comparative Cross-sectional Study
Authors: Yarjanli Mahsa , Sadatmahalleh Shahideh Jahanian , Mirzaei Negin , Azarbajani Khadijeh 
Published: July 2022

Abstract
Background: Polycystic ovary syndrome (PCOS) coexisting mood disorders along with a combination of aesthetic manifestations may have a detrimental effect on women's sexual function. Hence, different phenotypes of PCOS have different clinical and biochemical signs and symptoms. The aim of this study was to compare women's sexual function (SF) in different phenotypes of PCOS.Methods: This cross-sectional study was conducted on 364 women who met the Rotterdam diagnostic criteria to compare different PCOS phenotypes (A=95, B=78, C=95, and D=95). All patients were invited to fill out the female sexual function index (FSFI).Results: Significant differences were observed between the different phenotypes in terms of the total score, sexual desire, arousal, lubrication, and satisfaction (P<0.001); however, no significant differences were found between them in the terms of pain (P>0.05) and orgasm (P>0.05). In addition, phenotype B had the lowest mean score of total FSFI (P<0.05).Conclusion: The results indicated that women's SF is significantly different in different PCOS phenotypes. It is concluded that in order to solve the SF problems of women with PCOS, different treatment and care measures should be considered according to the relevant phenotype.
3D mapping of intra-articular calcaneal fractures
Authors: Shi Guang , Lin Zhao , Liao Xun , Liu Wei , Zhan Hongrui , Cai Xiyu 
Published: July 2022

Abstract
Background: To determine the pattern of intra-articular calcaneal fractures (ICFs) by a three-dimensional (3D) mapping and determine whether there were consistent fracture patterns and comminution zones. Methods: Sixty-seven patients with ICFS by CT scan were included. The calcaneal fractures fragments in CT were multiplanar reconstructed and virtual reduced. 3D heat mapping was subsequently created by graphically superimposing all fracture lines onto a standard calcaneal template.Results: The cohort included 26 (38.8%) left calcaneal fractures, 27 (40.30%) right calcaneal fractures, and 14 (20.9%) cases with bilateral fractures. Comminuted fractures accounted for 92.5%. Sagittal 3D mapping shows that the fracture line is mainly concentrated at the critical angle of Gissane and extending rear to the posterior of the tuberosity of the lateral wall and the anterior of the medial process of the calcaneus tuberosity but with more significant variation in the medial wall. The average angle of fracture lines concerning the long calcaneal axis (LCA) was 29.1°and 19.2° in the lateral and medial walls. Axial 3D mapping shows that fracture lines were primarily concentrated in the anterior area to the posterior joint facet and extending along the rear joint facet and calcaneus sulcus to the posteriorly of the tuberosity. The mean angle of fracture lines concerning the LAC was 11° in the axial wall. Conclusion: The data provided elucidated that ICFs have consistent characteristic fracture patterns and comminution zones. This study provides visual guidelines for understanding fracture morphology, which may assist with fracture classification, preoperative planning, development of fixation concepts.
Development and effect of poultry lymphoid tissue supplement on cell viability in culture
Authors: Kolberg Natalia , Tikhonova Nataliya , Tikhonov Sergey , Leontieva Svetlana , Sergeeva Irina 
Published: July 2022

Peptides are biologically active. This quality depends on the technological modes of protein hydrolysis. The research objective was to isolate peptides from the bursa fabricii and evaluate their immunotropic effect on mice of various lines with experimental immunodeficiency and the morphofunctional state of their immunopoiesis organs, i.e., thymus and spleen.
The research featured bursa fabricii hydrolysate and peptides, as well as thymus and spleen of male mice. Amine nitrogen was determined according to State Standard R 55479-2013; molecular weight of peptides was determined by gel electrophoresis. The morphometry of the thymus and spleen was calculated using VideoTesT-Morphology 5.0.
The research revealed the rational modes of enzymatic hydrolysis of the bursa fabricii protein by papain with subsequent isolation of peptides by ultrafiltration. According to the content of amine nitrogen in the bursa fabricii hydrolysate, the rational concentration of the papain enzyme was 0.15%. The molecular weight of peptides after ultrafiltration of bursa fabricii hydrolysate through membranes with a 43 kDa permeability had different values and depended on the concentration of papain, hydrolysis time, and temperature. The maximal amount of 27–18 kDa peptides was isolated at 36°C (85%) when the concentration of papain was 0.15% (73%), the hydromodule was 1:3 (78%), and the hydrolysis time of the raw material was 6 h (82%). The rational technological parameters of the hydrolysis of the bursa fabricii protein were as follows: concentration of papain – 0.15%, temperature – 36°C, hydromodule – 1:3, and hydrolysis time – 6 h. In immunodeficient mice, bursal peptides prevented a decrease in total cellularity in the thymus, sustained the content of CD3+ cells, activated the maturation of T-lymphocytes and proliferation of B-lymphocytes, and reduced the immunocytotoxic effects of cyclophosphamide.
The article offers a new technology for obtaining peptides with a pronounced immunotropic effect that can be used in functional food production.