bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis kemampuan berpikir kreatif matematis siswa kelas VIII SMP BP Tahfidz At-Taubah batam Tahun pelajaran 2020/2021
Authors: Rakhmawati Desti , Husna Asmaul , Gusmania Yesi 
Published: November 2022

Abstrak. Berpikir kreatif sangatlah penting untuk siswa, berpikir kreatif dibutuhkan siswa ketika mendapatkan sebuah masalah yang belum pernah dihadapi sebelumnya. Tujuan penelitian ini adalah untuk mendeskripsikan kemampuan berpikir kreatif matematis siswa kelas VIII dalam menyelesaikan soal persamaan linear dua variabel. Adapun indikator kemampuan berpikir kreatif matematis yang diukur meliputi kelancaran, keluwesan, keaslian dan elaborasi. Penelitian ini merupakan jenis penelitian deskriptif kualitatif dengan subjek penelitian adalah siswa kelas VIII C SMP BP Tahfidz At-Taubah Batam yang berjumlah 18 siswa. Teknik pengumpulan data menggunakan tes dan wawancara. Data yang terkumpul dianalisis dengan prosedur menurut Miles dan Huberman yang meliputi reduksi data, penyajian data dan menarik kesimpulan. Tes berupa soal uraian kemampuan berpikir kreatif matematis yang berjumlah 4 soal dengan reliabilitas sebesar 0,67. Berdasarkan hasil analisis, diperoleh 77,78 % subjek yang memenuhi indikator kelancaran, 16,67 % subjek yang memenuhi indikator keluwesan, 72,22 % subjek memenuhi pada indikator elaborasi dan 83,33 % subjek yang memenuhi indikator keaslian. Dari hasil yang sudah dipaparkan masih perlu ditingkatkan kemampuan berpikir kreatif siswa pada indikator keluwesan.Kata kunci: Berpikir Kreatif Matematis, Kemampuan Berpikir, Persamaan Linear Dua Variabel Abstract. Creative thinking is very important for students, creative thinking is needed when students get a problem that has never been faced before. The purpose of this study was to describe the mathematical creative thinking ability of class VIII students in solving linear equations of two variables. The indicators of mathematical creative thinking skills measured include fluency, flexibility, originality and elaboration. This research is a type of descriptive qualitative research with the research subjects are students of class VIII C SMP BP Tahfidz At-Taubah Batam, totaling 18 students. Data collection techniques using tests and interviews. The data collected were analyzed by Miles and Huberman's procedures which include data reduction, data presentation and drawing conclusions. The test is in the form of a description of mathematical creative thinking skills, totaling 4 questions with a reliability of 0.67. Based on the results of the analysis, obtained 77.78% of the subjects who met the fluency indicator, 16.67% of the subjects who met the flexibility indicator, 72.22% of the subjects met the elaboration indicator and 83.33% of the subjects who met the authenticity indicator. From the results that have been presented, it is still necessary to improve students' creative thinking skills on the indicators of flexibility.Keywords: Mathematical Creative Thinking, Thinking Ability, Two Variable Linear Equations
Bacteriophage-based decontamination to control environmental colonization by Staphylococcus capitis in neonatal intensive care units: An in vitro proof-of-concept
Authors: Chavignon Marie , Kolenda Camille , Medina Mathieu , Bonhomme Mélanie , Blazere Leslie , Legendre Tiphaine , Tristan Anne , Laurent Frédéric , Butin Marine 
Published: November 2022

IntroductionIn neonatal intensive care units (NICUs), the standard chemical-based disinfection procedures do not allow a complete eradication of pathogens from environmental surfaces. In particular, the clone Staphylococcus capitis NRCS-A, a significant pathogen in neonates, was shown to colonize neonatal incubators. The aim of this study was to evaluate the in vitro effect of a bacteriophage cocktail on NRCS-A eradication.MethodsThree bacteriophages were isolated, genetically characterized and assessed for their host range using a collection of representative clinical strains (n=31) belonging to the clone NRCS-A. The efficacy of a cocktail including these three bacteriophages to eradicate the reference strain S. capitis NRCS-A CR01 was determined in comparison or in combination with the chemical disinfectant Surfanios Premium on either dry inoculum or biofilm-embedded bacteria. The emergence of bacterial resistance against the bacteriophages alone or in cocktail was evaluated by growth kinetics.ResultsThe three bacteriophages belonged to two families and genera, namely Herelleviridae/Kayvirus for V1SC01 and V1SC04 and Rountreeviridae/Andhravirus for V1SC05. They were active against 17, 25 and 16 of the 31 tested strains respectively. Bacteriophage cocktails decreased the bacterial inoculum of both dry spots and biofilms, with a dose dependent effect. The sequential treatment with bacteriophages then Surfanios Premium did not show enhanced efficacy. No bacterial resistance was observed when using the bacteriophage cocktail.DiscussionThis study established a proof-of-concept for the use of bacteriophages to fight against S. capitis NRCS-A. Further investigations are needed using a larger bacterial collection and in real-life conditions before being able to use such technology in NICUs
Pseudohypoparathyroidism during pregnancy and the postpartum period: A case series of five patients
Authors: Wang Jia-Jia , Yang Yi , Wang Ya-Bing , Song An , Jiang Yan , Li Mei , Xia Wei-Bo , Liu Yan-Ping , Wang Ou , Xing Xiao-Ping 
Published: November 2022

ObjectivesPseudohypoparathyroidism (PHP) is a rare disease, especially when combined with pregnancy. We aimed to explore the changes in serum calcium/parathyroid hormone (PTH) level and medical treatment in a case series of PHP during pregnancy and the postpartum period.MethodsA total of five PHP patients with six pregnancies were enrolled. The classification of PHP was based on (epi)genetic analysis. Clinical characteristics, biochemical indices, and treatment strategies before, during, and after pregnancy were retrospectively collected.ResultsAll patients received calcium and vitamin D agents with nearly normal serum calcium before pregnancy except patient 2 who was found hypocalcemic during gestation. All patients chose Cesarean section, and one suffered preterm delivery due to oligoamnios. The neonatal birth weight ranged from 2,250 to 4,300 g, and all neonates were free of hypocalcemia-related symptoms. The change in calcium metabolism was inconsistent including stable, improved, or worsened during pregnancy. Serum PTH level remained low in the first two trimesters in patients with stable and improved conditions while increased in the last two trimesters in patients with a worsened condition. Serum calcium changed inconsistently while PTH increased consistently during lactation. For patients who did not breastfeed, calcium homeostasis improved after delivery.ConclusionCalcium homeostasis and medicine dosage changed differently in PHP patients during pregnancy and lactation. However, most patients had good pregnancy outcomes. Serum PTH levels might predict changes in calcium metabolism during pregnancy.
Infill well placement optimization for secondary development of waterflooding oilfields with SPSA algorithm
Authors: Li Congcong , Fang Chaoqiang , Huang Yougen , Zuo Hailong , Zhang Zhang , Wang Shuoliang 
Published: November 2022

A significant amount of bypassed oil resources often remain in a mature waterflooding reservoir because of non-uniform sweep caused by natural complexities of a subsurface reservoir and improper management of the reservoir. Infill drilling is one of the most attractive options for increasing oil recovery in consequence of its operational simplicity, low risk and promising results. Determining optimal infill well placements in heterogeneous mature reservoirs is a critical and challenging task that has a significant impact on the recovery performance and economic revenue of subsurface remaining oil resources. An integrated framework is constructed to attain best-obtained optimal location and completion of infill wells in multi-layer mature oil reservoirs. The placement of an infill vertical well is parameterized in terms of two sets of variables that define the location and completion respectively. A variant of SPSA algorithm is used to solve the defined optimization problem. The performance of the proposed algorithm is first tested for the joint optimization of well location and completion of an injection well using a synthetic model. The results show that the algorithm with average SPSA gradients outperforms the single SPSA gradient method both in solution and convergence rate. Besides, there are two plateaus on the performance curve of all algorithms: on the first plateau, each algorithm is approaching to its optimal well location with relatively little change on the completion parameters, while on the second plateau, each algorithm obtains the corresponding optimal completions. A complex heterogeneous reservoir model is then constructed by using the data of a mature oil reservoir in Shengli Oilfield in China to design an optimal 10 years’ infill drilling program. Four vertical production wells are placed in the oil-rich regions and both simultaneous and sequential algorithms are tried to obtain their optimal locations and completions. The performances of simultaneous joint optimization and sequential joint optimization are compared and as a result it is recommended to use sequential joint optimization as the optimization algorithm in the integrated framework.
The published trend of studies on COVID-19 and dietary supplements: Bibliometric analysis
Authors: Hu Wenzhong , Xu Yun 
Published: November 2022

BackgroundThere are no guidelines on dietary supplements for the prevention or treatment of COVID-19. Therefore, we would like to analyze and discuss the above confusion through the bibliometric analysisMethodsOn 3 September 2022, we conducted a search of all relevant literature retrieved from the WOS core collection database from 2019 to 2022. CiteSpace software is used to build the visual co-occurrence networkResultsIn the study of “COVID-19 and Dietary Supplements”, the total of 170 authors published 855 articles in 451 journals. Several distinct core author groups were formed by Wang, Grant, Singh, Zhu, and other authors with numerous publications. The majority of the publications came from the Shahid Beheshti University of Medical Sciences. The United States of America had the highest number of publications. By analyzing keyword clusters, we found that the research focus was dietary supplements (vitamin D, vitamin K, vitamin C), mechanisms (ferritin, specialized pro-resolving mediators (SPMs), oxidative stress), research methods (clinical trials), and the prevention and treatment strategies (lockdown) of COVID-19Conclusionsvitamin D is the mainstream dietary supplement for COVID-19. There are still numerous controversies that deserve further discussion. Such as whether the use of vitamin D or TCM offers benefits, and whether the addition of dietary supplements during the lockdown measures can help prevent COVID-19 infection.
Unspecific reactivity must be excluded in COVID-19 epidemiological analyses or virus tracing based on serologic testing: Analysis of 46,777 post-pandemic samples and 1,114 pre-pandemic samples
Authors: Cai Min-Jing , Lin Jie , Zhu Jian-Hui , Dai Zhang , Lin Yi-Qiang , Liang Xian-Ming 
Published: November 2022

BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). Serologic testing is complementary to nucleic acid screening to identify SARS-CoV-2. This study aimed to evaluate unspecific reactivity in SARS-CoV-2 serologic tests.Materials and methodsTotal anti-SARS-CoV-2 antibodies from 46,777 subjects who were screened for SARS-CoV-2 were retrospectively studied to evaluate the incidence and characteristics of the unspecific reactivity. A total of 1,114 pre-pandemic samples were also analysed to compare unspecific reactivity.ResultsThe incidence of unspecific reactivity in anti-SARS-CoV-2 total antibody testing was 0.361% in 46,777 post-pandemic samples, similar to the incidence of 0.359% (4/1,114) in 1,114 pre-pandemic samples (p = 0.990). Subjects ≥ 19 years old had a 2.753-fold [95% confidence interval (CI), 1.130–6.706] higher probability of unspecific reactivity than subjects &lt; 19 years old (p = 0.026). There was no significant difference between the sexes. The unspecific reactivity was associated with 14 categories within the disease spectrum, with three tops being the skin and subcutaneous tissue diseases (0.93%), respiratory system diseases (0.78%) and neoplasms diseases (0.76%). The percentage of patients with a titer ≥ 13.87 cut-off index (COI) in the unspecific reactivity was 7.69%.ConclusionOur results suggest a unspecific reactivity incidence rate of 0.361% involving 14 categories on the disease spectrum. Unspecific reactivity needs to be excluded when performing serologic antibody testing in COVID-19 epidemiological analyses or virus tracing.
Expansion of the mutation spectrum and phenotype of USP7-related neurodevelopmental disorder
Authors: Zheng Hong , Mei Shiyue , Li Fuwei , Wei Liwan , Wang Yanchu , Huang Jinrong , Zhang Feng , Huang Jia , Liu Yanping , Gu Weiyue , Liu Hongyan 
Published: November 2022

BackgroundHao-fountain syndrome (HAFOUS) is a neurodevelopmental syndrome characterized by global developmental and severe language delays, behavioral abnormalities (including autism), and mild dysmorphic impairment of intellectual development. It is a dominant genetic disease caused by USP7 gene (*602519) mutations on chromosome 16p13.2. So far, only 15 cases with 14 deleterious variants in the USP7 gene have been reported.Materials and methodsThis study describes three unrelated patients with USP7 variants. Besides, we identified novel de novo heterozygous USP7 variants using trio-whole exome sequencing and verified by Sanger sequencing. Furthermore, clinical characteristics were evaluated by reviewing the medical records.ResultsThe three identified variants, i.e., one frameshift variant (c.247_250del, p.Glu83Argfs × 18) and two missense variants (c.992A &gt; G, p.Tyr331Cys; c.835T &gt; G, p.Leu279Val) are unreported. The predominant clinical manifestations of the three patients included: DD/ID; language impairment; abnormal behavior; abnormal brain magnetic resonance (dilation of lateral ventricles, dilation of Virchow-Robin spaces, dilated the third ventricle, abnormal cerebral white matter morphology in bilateral occipital lobes, hypodysplasia of the corpus callosum, arachnoid cyst, delayed myelination, and widened subarachnoid space); some also had facial abnormalities.ConclusionIn summary, DD/ID is the most prevalent clinical phenotype of HAFOUS, although some patients also exhibit language and behavioral abnormalities. For the first time in China, we identified three variants of the USP7 gene using whole-genome sequence data. This work expands the USP7 gene mutation spectrum and provides additional clinical data on the clinical phenotype of HAFOUS.
Comprehensive dosimetric and clinical evaluation of lexicographic optimization-based planning for cervical cancer
Authors: Trivellato Sara , Caricato Paolo , Pellegrini Roberto , Montanari Gianluca , Daniotti Martina Camilla , Bordigoni Bianca , Faccenda Valeria , Panizza Denis , Meregalli Sofia , Bonetto Elisa , Arcangeli Stefano , De Ponti Elena 
Published: November 2022

AimIn this study, a not yet commercially available fully-automated lexicographic optimization (LO) planning algorithm, called mCycle (Elekta AB, Stockholm, Sweden), was validated for cervical cancer.Material and methodsTwenty-four mono-institutional consecutive treatment plans (50 Gy/25 fx) delivered between November 2019 and April 2022 were retrospectively selected. The automatic re-planning was performed by mCycle, implemented in the Monaco TPS research version (v5.59.13), in which the LO and Multicriterial Optimization (MCO) are coupled with Monte Carlo calculation. mCycle optimization follows an a priori assigned priority list, the so-called Wish List (WL), representing a dialogue between the radiation oncologist and the planner, setting hard constraints and following objectives. The WL was tuned on a patient subset according to the institution’s clinical protocol to obtain an optimal plan in a single optimization. This robust WL was then used to automatically re-plan the remaining patients. Manual plans (MP) and mCycle plans (mCP) were compared in terms of dose distributions, complexity (modulation complexity score, MCS), and delivery accuracy (perpendicular diode matrices, gamma analysis-passing ratio, PR). Their clinical acceptability was assessed through the blind choice of two radiation oncologists. Finally, a global quality score index (SI) was defined to gather into a single number the plan evaluation process.ResultsThe WL tuning requested four patients. The 20 automated re-planning tasks took three working days. The median optimization and calculation time can be estimated at 4 h and just over 1 h per MP and mCP, respectively. The dose comparison showed a comparable organ-at-risk spare. The planning target volume coverage increased (V95%: MP 98.0% [95.6–99.3]; mCP 99.2%[89.7–99.9], p &gt;0.05). A significant increase has been registered in MCS (MP 0.29 [0.24–0.34]; mCP 0.26 [0.23–0.30], p &lt;0.05) without affecting delivery accuracy (PR (3%/3mm): MP 97.0% [92.7–99.2]; mCP 97.1% [95.0–98.6], p &gt;0.05). In the blind choice, all mCP results were clinically acceptable and chosen over MP in more than 75% of cases. The median SI score was 0.69 [0.41–0.84] and 0.73 [0.51–0.82] for MP and mCP, respectively (p &gt;0.05).ConclusionsmCycle plans were comparable to clinical manual plans, more complex but accurately deliverable and registering a similar SI. Automated plans outperformed manual plans in blinded clinical choice.
Glucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis
Authors: Xie Wenting , Su Fugui , Wang Guizhong , Peng Zichong , Xu Yaomin , Zhang Yi , Xu Ningning , Hou Kaijian , Hu Zhuping , Chen Yan , Chen Rongping 
Published: November 2022

Background: Insulin secretory agents are commonly used to treat type 2 diabetes. However, traditional insulin secretory agents such as sulfonylureas and glinides have side effects of hypoglycemia. In recent years, researchers have discovered that berberine can inhibit the voltage-gated k+ channels of pancreatic β cell membrane and promote insulin secretion without causing hypoglycemia, because the glucose-lowering effects of berberine are only under hyperglycemic conditions or in a high-glucose-dependent manner. In order to shed light on the glucose-lowing effects of berberine in type 2 diabetes with different baseline fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c), we conducted a meta-analysis of randomized controlled trials.Methods: We searched eight databases, which included PubMed, EMBASE, Web of Science, the Cochrane Library, and the Chinese databases such as Sino-Med, China National Knowledge Infrastructure (CNKI), Wanfang Database, and VIP Database for Chinese Technical Periodicals, for randomized controlled trials, with berberine as the intervention and patients with type 2 diabetes mellitus as subjects, published up until November 2021. We analyzed the glucose-lowing effects of berberine, including its effects on FPG, HbA1c and 2-h plasma blood glucose (2hPBG), by calculating weighted mean differences (WMD) and 95% confidence interval (CI). To assess the safety of berberine, we analyzed the incidence of total adverse events and hypoglycemia by calculating relative risk (RR) and 95% CI.Results: Thirty-seven studies involving 3,048 patients were included in the meta-analysis. The results showed that berberine could reduce FPG (WMD = -0.82 mmol/L, 95% CI (-0.95, -0.70)), HbA1c (WMD = -0.63%, 95% CI (-0.72, -0.53)), and 2hPBG (WMD = -1.16 mmol/L, 95% CI (-1.36, -0.96)), with all results being statistically significant. Subgroup analyses revealed that the glucose-lowering effect of berberine was associated with baseline mean FPG and HbA1c in type 2 diabetes. In addition, berberine alone or in combination with oral hypoglycemic agents (OHAs) in the treatment of T2DM did not significantly increase the incidence of total adverse events (RR = 0.73, 95% CI (0.55, 0.97), p = 0.03) and the risk of hypoglycemia (RR = 0.48, 95% CI (0.21, 1.08), p = 0.08).Conclusion: Berberine has a glucose-lowering effect, which is related to the baseline FPG and HbA1c levels of patients. Treatment with berberine may be safe since it does not increase the incidence of total adverse events and the risk of hypoglycemia.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=292975, identifier CRD42021292975.
One size does not fit all. Should gambling loss limits be based on income?
Authors: Langeland Elias , Johnsen Ingvild Faxvaag , Sømme Kaja Kastrup , Morken Arne Magnus , Erevik Eilin Kristine , Kolberg Eirin , Jonsson Jakob , Mentzoni Rune Aune , Pallesen Ståle 
Published: November 2022

BackgroundPrevious research has suggested empirically based gambling loss limits, with the goal of preventing gambling related harm in the population. However, there is a lack of studies relating gambling loss limits to individual factors such as income. The current study examines whether gambling loss limits should be income-specific.Materials and methodsThe dataset was derived from three representative cross-sectional surveys of the Norwegian population and consisted of 14,630 gamblers. Four income groups, based on a quartile approximation, were formed. Gambling related harm was measured with the Problem Gambling Severity Index (PGSI), and precision-recall (PR) analyses were used to identify loss limits for the different income groups at two levels of gambling severity: moderate-risk gambling and problem gambling.ResultsFor both levels of gambling severity, we found the lowest income group to have the lowest gambling loss limits, and the highest income group to have the highest loss limits, which compared to the loss limits for the total sample, were lower and higher, respectively. Calculating the cut-offs for moderate-risk gamblers, we found a consistently ascending pattern from the lowest to the highest income group. Calculating the cut-offs for problem gamblers, we found a similar pattern except for the two middle income groups.ConclusionThe results suggest that income moderates empirically derived gambling loss limits. Although replication is required, income-based gambling loss limits may have higher applied value for preventing gambling related harm, compared to general loss limits aimed at the entire population.