bluuebunny/crossref_metadata_2025_split huggingface dataset:
Operation extension in gas turbine-based advanced cycles with a surge prevention tool
Authors: Reggio Federico , Silvestri P. , Ferrari M. L. , Massardo A. F. 
Published: June 2022

AbstractThis work aims to present the development and testing of an innovative tool for surge prevention in advanced gas turbine cycles. The presence of additional components, such as a saturator in humid cycles, a heat exchanger for an external combustor, a solar receiver or fuel cell stack in a hybrid system, implies the presence of larger size volumes between compressor outlet and recuperator or expander inlet. This large volume increases the risk of incurring in surge instability, especially during dynamic operations. For these reasons, at the University of Genoa, the Thermochemical Power Group (TPG) has implemented four surge precursors in a new diagnostic real-time software which can recognise a surge incipience condition comparing the precursor values with a set of moving thresholds. The most innovative aspects of this work are: (i) operational range extension and safer management of advanced gas turbine systems for energy generation, (ii) positive impact in energy efficiency due to this range extension of high efficiency systems, (iii) development of a new diagnostic tool for surge prevention using standard probes, (iv) small impact of this tool on the control and sensor costs, (v) software flexibility for adaptation to different conditions and machines. This very important final aspect is obtained with thresholds able to change automatically to adapt themselves to the plant and machine operational regime. From the cost point of view, the utilization of standard measurements is an essential requirement to equip commercial machines without significant impact on the capital costs. The software performance has been demonstrated using experimental data from a test rig composed of a T100 microturbine connected with a modular vessel, which permits to generate the effect of additional components (especially from the volume size point of view). Vibro-acoustic data, collected during machine transients from a stable operative condition to surge, were used to tune all the software parameters and to obtain a good surge predictivity.
Comparative chloroplast genomes and phylogenetic analyses of Pinellia
Authors: Cui Ning , Chen Weixu , Li Xiwen , Wang Ping 
Published: June 2022

Abstract
Background
Pinellia Tenore (Araceae) is a genus of perennial herbaceous plants, all of which have medicinal value. The chloroplast (cp) genome data of Pinellia are scarce, and the phylogenetic relationship and gene evolution remain unclear.

Methods and results
We sequenced and annotated the Pinellia pedatisecta cp genome and combined it with previously published genomes for other Pinellia species. We used bioinformatics methods to analyse the genomic structure, repetitive sequences, interspecific variation, divergence hotspots, phylogenetic relationships, divergence time estimation and selective pressure of four Pinellia plastomes. Results showed that the cp genomes of Pinellia varied in length between 168,178 (P. pedatisecta MN046890) and 164,013 bp (P. ternata KR270823). A total of 68–111 SSR loci were identified as candidate molecular markers for further genetic diversity study. Eight mutational hotspot regions were determined, including psbI-trnG-UCC, psbM-rpoB, ndhJ-trnT-UGU, trnP-UGG-trnW-CCA, ndhF-trnN-GUU, ndhG-ndhE, ycf1-rps15 and trnR-ycf1. Gene selection pressure suggested that four genes were subjected to positive selection. Phylogenetic inferences based on the complete cp genomes revealed a sister relationship between Pinellia and Arisaema plants whose divergence was estimated to occur around 22.48 million years ago. All Pinellia species formed a monophyletic evolutionary clade in which P. peltata, rather than P. pedatisecta, earlier diverged, indicating that P. pedatisecta is not the basal taxon of Pinellia but P. peltata may be.

Conclusions
The cp genomes of Pinellia will provide valuable information for species classification, identification, molecular breeding and evolutionary exploration of the genus Pinellia.
Molecular Phylogenetic Analysis of Candida krusei
Authors: Domán Marianna , Makrai László , Bányai Krisztián 
Published: June 2022

AbstractRevealing the phylogenetic relationships of Candida krusei strains (sexual form Pichia kudriavzevii) is a prerequisite for understanding the evolution of its virulence-associated mechanisms and ecological lifestyles. Molecular phylogenetic analyses based on entire internal transcribed spacer region (ITS) and multilocus sequence typing (MLST) data were carried out with sequences available in public databases and Hungarian isolates from animals obtained for the study. The ITS haplotype network yielded a high frequency haplotype at the centre of the network (H1; n = 204) indicating that various selective pressure might resulted in population expansion from H1. MLST analysis identified three new genotypes among animal-derived isolates, therefore overall 203 sequence types were investigated to determine the population structure of C. krusei. The most commonly encountered sequence types were ST 17 and ST 67. Phylogenetic analyses showed diverse genetic construction of C. krusei population. Evidence of potential recombination events were also observed that might play some role in high intraspecies genetic variability among strains, however, the limited data of C. krusei genotypes from different countries prevented us to identify accurate evolutionary routes of commensal and pathogenic strains or species-specific lineages. Further expansion of C. krusei MLST database may promote the better understanding of the mixed evolutionary history of this species.
Lie Symmetries of Fundamental Solutions to the Leutwiler-Weinstein Equation
Authors: Aksenov Aleksandr V. , Orelma Heikki 
Published: June 2022

AbstractIn this article, we study Lie symmetries to fundamental solutions to the Leutwiler-Weinstein equation $$ Lu:={\Delta} u+\frac{k}{x^{n}}\frac{\partial u}{\partial x^{n}}+\frac{\ell}{(x^{n})^{2}}u=0 $$

L
u
:
=
Δ
u
+

k

x

n

∂
u

∂

x

n

+

ℓ

(

x

n

)

2

u
=
0

in the upper half-space $\mathbb {R}^{n}_{+}$

ℝ

+

n

. Starting from the infinitesimal generators of the equation Lu = 0, we deduce symmetries of the equation Lu = δ(x − x0), and using its invariant solutions, we construct a fundamental solution. As an application, we study a Green functions of the operator in the hyperbolic unit ball.
The Volatility of Housing Prices: Do Different Types of Financial Intermediaries Affect Housing Market Cycles Differently?
Authors: Braun Julia , Burghof Hans-Peter , Langer Julius , Einar Sommervoll Dag 
Published: June 2022

AbstractHousing markets display several correlations to multiple economic sectors of an economy. Their enormous impact on economies’ health, wealth, and stability is uncontroversial. Interestingly, the forms of financing residential property vary widely between the different countries in terms of both, the available product types and the institutions offering them. This research examines the implications of different financial intermediaries on housing market cycles with special emphasis on two institutional types, conventional banks and building and loan associations. Introducing a heterogeneous agent-based model, the interactions of buyers, sellers, and the two types of credit institutions are assessed. Heterogeneous economic principles and expectations of agents create endogenous market conditions which are strongly influenced by the lending practices of financial intermediaries.Focusing primarily on collateral values to decide about lending, conventional banks may contribute to volatile housing markets which are prone to recessions. Building and loan associations, on the other hand, rely to a greater extent on endogenously created borrower information. Thus, they are able to cushion the volatility of house prices caused by procyclical mortgage lending of conventional banks and increase the stability of the housing market. Simulations show that the most stable market conditions are attained if both types of financial intermediaries serve the mortgage lending market jointly. Furthermore, transaction and homeownership rates are the highest in this market setting. These findings advocate in favor of diversified financial markets.
Systemic inflammatory markers in relation to cognitive function and measures of brain atrophy: a Mendelian randomization study
Authors: Luo Jiao , le Cessie Saskia , Blauw Gerard Jan , Franceschi Claudio , Noordam Raymond , van Heemst Diana 
Published: June 2022

AbstractObservational studies have implied associations between multiple cytokines and cognitive decline, anti-inflammatory drugs however did not yield any protective effects on cognitive decline. We aimed to assess the associations of systemic inflammation, as measured by multiple cytokine and growth factor, with cognitive performance and brain atrophy using two-sample Mendelian randomization (MR). Independent genetic instruments (p < 5e − 8 andp < 5e − 6) for 41 systemic inflammatory markers were retrieved from a genome-wide association study conducted in 8293 Finnish participants. Summary statistics for gene-outcome associations were obtained for cognitive performance (N = 257,841) and for brain atrophy measures of cerebral cortical surface area and thickness (N = 51,665) and hippocampal volume (N = 33,536). To rule out the heterogeneity in the cognitive performance, we additionally included three domains: the fluid intelligence score (N = 108,818), prospective memory result (N = 111,099), and reaction time (N = 330,069). Main results were computed by inverse-variance weighting; sensitivity analyses taking pleiotropy and invalid instruments into account were performed by using weighted-median estimator, MR-Egger, and MR PRESSO. After correcting for multiple testing using false discovery rate, only genetically predicted (withp < 5e − 6 threshold) per-SD (standard deviation) higher IL-8 was associated with − 0.103 (− 0.155, − 0.051,padjusted = 0.004) mm3smaller hippocampal volume and higher intelligence fluid score [β: 0.103 SD (95% CI: 0.042, 0.165),padjusted = 0.041]. Sensitivity analyses generally showed similar results, and no pleiotropic effect, heterogeneity, or possible reverse causation was detected. Our results suggested a possible causal association of high IL-8 levels with better cognitive performance but smaller hippocampal volume among the general healthy population, highlighting the complex role of inflammation in dementia-related phenotypes. Further research is needed to elucidate mechanisms underlying these associations.
Longitudinal associations between executive functions and metacognitive monitoring in 5- to 8-year-olds
Authors: Kälin Sonja , Roebers Claudia M. 
Published: June 2022

AbstractPronounced developmental progression during the transition to formal schooling can be found in executive functions (EF) and metacognition (MC). However, it is still unclear whether and how EF and MC influence each other during this transition. Previous research with young children suggests that inhibition may be a prerequisite for monitoring skills. Thus, the present longitudinal study investigated the association between the common subcomponents of EF (inhibition, working memory, and shifting) assessed in kindergarten (T1) and metacognitive monitoring assessed in 2nd grade (T2) in a sample of N = 84 children. In line with our hypothesis, the results revealed a significant link only between the EF subcomponent inhibition and later metacognitive monitoring. More precisely, children with better inhibition skills in kindergarten showed less overconfident monitoring in elementary school. Interestingly, the longitudinal relationship between inhibition and monitoring was not bidirectional. The findings indicate an essential role of early inhibition skills regarding emerging and developing elementary school children’s monitoring skills.
Preservation, modernization, and transformation: contesting bioeconomic imaginations of “manure futures” and trajectories toward a sustainable livestock system
Authors: Friedrich Jonathan , Zscheischler Jana , Faust Heiko 
Published: June 2022

AbstractIn discourses on sustainability, its underlying conceptualizations and meanings, the role of imaginations and their influence on concrete social practices and mutually dependent sociomaterial structures have been overlooked. Therefore, our article uses Adloff and Neckel’s (Sustain Sci 14(4):1015-1025, 2019) conceptual framework to explore the role of imaginations in generating different trajectories from a concrete environmental problem, namely issues attributed to manure surpluses in Germany, to assess the hurdles and conflicting goals of a transformation toward a sustainable livestock system. Our study builds on qualitative, semistructured, and problem-centered interviews with both new innovation actors and incumbent actors in the current system. Our results show that different trajectories of “manure futures” exist, as we identify “preservation”, “modernization” and “transformation” as trajectories representing ideal types of change. We discuss the results in light of the theory of imaginations and reflect on the usefulness of the concept of imaginations for analyzing environmental discourses and practices. Furthermore, we find that normative framings of problems rather than factual knowledge describe contesting imaginations as barriers to sustainability transformations, a point that must be acknowledged when developing a sustainable livestock system. We conclude that contesting imaginations could result in conflicts that must be moderated as drivers for change yet could also point to transformations that are already underway.
Ursodeoxycholic acid as adjuvant treatment to phototherapy for neonatal hyperbilirubinemia: a systematic review and meta-analysis
Authors: Kuitunen Ilari , Kiviranta Panu , Sankilampi Ulla , Renko Marjo 
Published: June 2022

Abstract
Background
Neonatal hyperbilirubinemia is observed in most newborns, and 5–15% of neonates require phototherapy. Phototherapy is effective but often prolongs hospitalization and has both short-term and potential long-term harms. The aim of this systematic review and meta-analysis was to evaluate the role of ursodeoxycholic acid (UDCA) combined with phototherapy in neonatal hyperbilirubinemia.

Methods
A literature search was conducted on September 1, 2021; 590 studies were screened, and 17 full texts were assessed by two authors. We included randomized controlled trials with or without placebo intervention. Primary outcomes were changes in total bilirubin levels at 24 hours and phototherapy duration. We calculated mean differences with 95% confidence intervals (CI).

Results
Six studies with 880 neonates were included. Of these studies, only two used a placebo-controlled double-blinded design. The overall risk of bias was high in one and moderate in four of the included studies. The mean decrease in the total bilirubin level during the first 24 hours was 2.06 mg/dL (95% CI 0.82–3.30; six studies) greater in the UDCA treatment group. The phototherapy duration was 19.7 hours (95% CI 10.4–29.1; five studies) shorter in the UDCA treatment group.

Conclusions
We found low-quality evidence that UDCA as an adjuvant to phototherapy seems to decrease total bilirubin faster and shorten phototherapy duration compared to standard treatment. Further studies are needed to confirm the efficacy, acute and long-term outcomes, and safety before implementing UDCA as an adjuvant to phototherapy in neonatal hyperbilirubinemia.
Investigation of the potential role of TGR5 in pancreatic cancer by a comprehensive molecular experiments and the liquid chromatography mass spectrometry (LC–MS) based metabolomics
Authors: Lei Yangyang , Li Guoping , Li Jianke , Gao Shanshan , Lei Ming , Gong Gaoquan , Li Changyu , Chen Yi , Wang Chenggang , Wang Xiaolin 
Published: June 2022

Abstract
Background
Takeda G protein receptor 5 (TGR5) is widely recognized as a potential drug target for the treatment of metabolic diseases. TGR5 is not only a metabolic regulator, but also has a potential role that participating in developing and progressing of gastrointestinal cancer. We aimed to investigate the potential role of TGR5 in pancreatic cancer by utilizing molecular experiments and the liquid chromatography mass spectrometry (LC–MS) based metabolomics.

Methods
Herein, we assessed pancreatic cancer proliferation, migration and invasion in response to TGR5 antagonist SBI-115 in vitro experiments. Cell death was examined by using TUNEL assay on agarose-embedded sections. Then we investigated the effects of TGR5 on PANC-1 and BXPC3 cells via transmission electron microscopy (TEM). Moreover, LC–MS-based metabolomics was performed to explore the potential underlying mechanisms of TGR5 in pancreatic cancer. The correlations between TGR5 and the metabolism-related genes were further analysed by GEPIA 2 database.

Results
We found the proliferation capacities were decreased significantly in PANC-1 and BXPC3 cells after the treatment of SBI-115 for 48 h. The results of TUNEL assay showed that antagonism of TGR5 by SBI-115 had a remarkable effect on inducing cell death. Analysis of TEM demonstrated that SBI-115 treatment could impair the morphology of mitochondria in most PANC-1 and BXPC3 cells. The LC–MS-based analyses revealed that antagonism of TGR5 could alter the metabolic profiles of PANC-1 cells in vitro. Moreover, TGR5 was associated with some metabolism-related genes in pancreatic cancer.

Conclusion
Our data suggests that antagonism of TGR5 may suppress cell proliferation and induce apoptosis in pancreatic cancer cells. TGR5 may affect the metabolism of pancreatic cancer, and TGR5 would be an attractive target for pancreatic cancer treatment.
Gene expression profiling and in vitro functional studies reveal RAD54L as a potential therapeutic target in multiple myeloma
Authors: Bong Ivyna Pau Ni , Ng Ching Ching , Othman Norodiyah , Esa Ezalia 
Published: June 2022

Abstract
Background
Current advances in the molecular biology of multiple myeloma (MM) are not sufficient to fully delineate the genesis and development of this disease.

Objective
This study aimed to identify molecular targets underlying MM pathogenesis.

Methods
mRNA expression profiling for 29 samples (19 MM samples, 7 MM cell lines and 3 controls) were obtained using microarray. We evaluated the in vitro effects of RAD54L gene silencing on the proliferation, apoptosis and cell cycle distribution in KMS-28BM human MM cells using siRNA approach. Cell proliferation was determined by MTS assay while apoptosis and cell cycle distribution were analysed with flow cytometry. Gene and protein expression was evaluated using RT-qPCR and ELISA, respectively.

Results
Microarray results revealed a total of 5124 differentially expressed genes (DEGs), in which 2696 and 2428 genes were up-regulated and down-regulated in MM compared to the normal controls, respectively (fold change ≥ 2.0; P < 0.05). Up-regulated genes (RAD54L, DIAPH3, SHCBP1, SKA3 and ANLN) and down-regulated genes (HKDC1, RASGRF2, CYSLTR2) have never been reported in association with MM. Up-regulation of RAD54L was further verified by RT-qPCR (P < 0.001). In vitro functional studies revealed that RAD54L gene silencing significantly induced growth inhibition, apoptosis (small changes) and cell cycle arrest in G0/G1 phase in KMS-28BM (P < 0.05). Silencing of RAD54L also decreased its protein level (P < 0.05).

Conclusions
This study has identified possible molecular targets underlying the pathogenesis of MM. For the first time, we reveal RAD54L as a potential therapeutic target in MM, possibly functioning in the cell cycle and checkpoint control.
Technology selection for holistic analysis of hybrid-electric commuter aircraft
Authors: Zumegen Clemens , Strathoff Philipp , Stumpf Eike , Wensveen Jasper van , Rischmüller Carsten , Hornung Mirko , Geiß Ingmar , Strohmayer Andreas 
Published: June 2022

AbstractElectric powertrains have different characteristics than conventional powertrains with combustion engines and require unconventional aircraft designs to evolve their full potential. Therefore, this paper describes a method to identify potential aircraft designs with electrified powertrains. Promising technology options in the fields of powertrain architecture, aerodynamic interactions, onboard systems and operating strategies were collected by the project partners of the LuFo project GNOSIS. The effect of the technology options on a commuter aircraft was evaluated in terms of global emissions ($$\hbox {CO}_{2}$$

CO
2

), local emissions ($$\text {NO}_{\text {X}}$$

NO
X

and noise) and operating costs. The evaluation considers an entry into service in 2025 and 2050 and is based on the reference aircraft Beechcraft 1900D. Literature review and simplified calculations enabled the evaluation of the aerodynamic interactions, systems and operating strategies. A preliminary aircraft design tool assessed the different powertrain architectures by introducing the two parameters ’power hybridization’ and ’power split’. Afterwards, compatible technology options were compiled into technology baskets and ranked using the shortest euclidean distance to the ideal solution and the farthest euclidean distance to the worst solution (Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method). An analysis of the CS 23 regulations leads to a high-wing design and excluded the partial turbo-electric powertrain architecture with the gas turbine in the aircraft tail. For 2025, a partial turbo-electric powertrain with two additional electric driven wingtip propellers was selected. A serial hybrid powertrain, which uses a gas turbine or fuel cell in combination with a battery, powers distributed electric propulsors at the wing leading edge in 2050. In both scenarios, the aircraft design includes an electric environmental control system, an electric driven landing gear and electro-hydraulic actuators for the primary flight control and landing gear.
Performance Evaluation of Transonic Axial Flow Compressor under Distorted Conditions by Groove Casing Technique with Tip Injection and Surface Roughness Effects
Authors: Srinivas G. , Raghunandana K. , Shenoy B. Satish 
Published: June 2022

AbstractThe aerodynamic performance and pressure ratio of modern aircraft engine compressor are degrading due to unsteady flow distorted aerodynamic loads and complex phenomena in the blade tip. This paper attempts to improve the performance of modern axial flow transonic compressor stage under distorted flow conditions by incorporating the combination of groove casing, tip injection technique with surface roughness effects. This is performed for the Mach number ranging between 0.8 and 1.3. The obtained numerical results are compared with experimental studies and found to be in good agreement. Through the numerical analysis, the compressor stage flow interaction with the shock waves as well as vortex formation and boundary layer separation is studied in detail. While evaluating the performance of the axial flow compressor, more emphasis is given to the flow properties like pressure, density, temperature, velocity, etc. The performance improvement is observed at a particular Mach number for a specified aerodynamic flow property.
A Narrative Review of Loneliness and Brain Health in Older Adults: Implications of COVID-19
Authors: Beadle Janelle N. , Gifford Angela , Heller Abi 
Published: June 2022

Abstract
Purpose of Review
This narrative review highlights important factors contributing to loneliness in older adults prior to and during the COVID-19 pandemic and effects on brain health.

Recent Findings
We characterize risk factors for loneliness in older adulthood and the impact of COVID-19. Furthermore, we discuss the implications of loneliness for older adults’ brain health.

Summary
Understanding the multifactorial causes of loneliness in different subpopulations of older adults both before and during the COVID-19 pandemic will provide insights for the development of interventions targeted to reduce loneliness in older adults based on their specific risk factors.