bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative Sagittal Balance Has Only a Limited Role in the Development of Adjacent Segment Disease After Lumbar Spine Fusion for Degenerative Lumbar Spine Disorders: A Subanalysis of the 10-year Follow-up Study
Authors: Toivonen Leevi A. , Mäntymäki Heikki , Häkkinen Arja , Kautiainen Hannu , Neva Marko H. 
Published: July 2022

Study Design.
Retrospective additional analysis of a prospective follow-up study.

Objectives.
We aimed to find out whether poor postoperative sagittal alignment increases revisions for adjacent segment disease (ASD) after lumbar spine fusion (LSF) performed for degenerative lumbar spine disease.

Summary of Background Data.
Revisions for ASD accumulate over time after LSF for degenerative lumbar spine disease. The etiology of ASD is considered multifactorial. Yet, the role of postoperative sagittal balance in this process remains controversial.

Materials and Methods.
A total of 215 consecutive patients who had undergone an elective LSF surgery for spinal stenosis with (80%) or without (20%) spondylolisthesis were analyzed. Spinal reoperations were collected from the hospital records. Preoperative and postoperative sagittal alignment were evaluated from standing radiographs. The risk of revisions for ASD was evaluated by Cox proportional hazards regression models.

Results.
We did not find the poor postoperative balance [pelvic incidence−lumbar lordosis (LL) >9°] to significantly increase the risk of revisions for ASD: crude hazard ratio (HR)=1.5 [95% confidence interval (CI): 0.8–2.7], adjusted (by age, sex, pelvic incidence, fusion length, and the level of the caudal end of fusion): HR=1.7 (95% CI: 0.9–3.3). We found higher LL outside the fusion segment (LL−segmental lordosis) to decrease the risk of revisions for ASD: HR=0.9 (95% CI: 0.9–1.0).

Conclusion.
Poor sagittal balance has only a limited role as a risk factor for the revisions for ASD among patients with degenerative spinal disease. However, the risk for ASD might be the greatest among patients with reduced spinal mobility.
Critical Appraisal of a Systematic Review: A Concise Review
Authors: Patel Jayshil J. , Hill Aileen , Lee Zheng-Yii , Heyland Daren K. , Stoppe Christian 
Published: July 2022

OBJECTIVES:
Concise definitive review of how to read and critically appraise a systematic review.

DATA SOURCES:
None.

STUDY SELECTION:
Current literature describing the conduct, reporting, and appraisal of systematic reviews and meta-analyses.

DATA EXTRACTION:
Best practices for conducting, reporting, and appraising systematic review were summarized.

DATA SYNTHESIS:
A systematic review is a review of a clearly formulated question that uses systematic and explicit methods to identify, select, and critically appraise relevant original research, and to collect and analyze data from the studies that are included in the review. Critical appraisal methods address both the credibility (quality of conduct) and rate the confidence in the quality of summarized evidence from a systematic review. The A Measurement Tool to Assess Systematic Reviews-2 tool is a widely used practical tool to appraise the conduct of a systematic review. Confidence in estimates of effect is determined by assessing for risk of bias, inconsistency of results, imprecision, indirectness of evidence, and publication bias.

CONCLUSIONS:
Systematic reviews are transparent and reproducible summaries of research and conclusions drawn from them are only as credible and reliable as their development process and the studies which form the systematic review. Applying evidence from a systematic review to patient care considers whether the results can be directly applied, whether all important outcomes have been considered, and if the benefits are worth potential harms and costs.
Differential regional cerebrovascular reactivity to end-tidal gas combinations commonly seen during anaesthesia
Authors: Mutch W. Alan C. , Duffin James 
Published: July 2022

BACKGROUND
Regional cerebrovascular reactivity (rCVR) is highly variable in the human brain as measured by blood oxygenation level-dependent (BOLD) MRI to changes in both end-tidal CO2 and O2.

OBJECTIVES
We examined awake participants under carefully controlled end-tidal gas concentrations to assess how regional CVR changes may present with end-tidal gas changes seen commonly with anaesthesia.

DESIGN
Observational study.

SETTING
Tertiary care centre, Winnipeg, Canada. The imaging for the study occurred in 2019.

SUBJECTS
Twelve healthy adult subjects.

INTERVENTIONS
Cerebral BOLD response was studied under two end-tidal gas paradigms. First end-tidal oxygen (ETO2) maintained stable whereas ETCO2 increased incrementally from hypocapnia to hypercapnia (CO2 ramp); second ETCO2 maintained stable whereas ETO2 increased from normoxia to hyperoxia (O2 ramp). BOLD images were modeled with end-tidal gas sequences split into two equal segments to examine regional CVR.

MAIN OUTCOME MEASURES
The voxel distribution comparing hypocapnia to mild hypercapnia and mild hyperoxia (mean FIO2 = 0.3) to marked hyperoxia (mean FIO2 = 0.7) were compared in a paired fashion (P < 0.005 to reach threshold for voxel display). Additionally, type analysis was conducted on CO2 ramp data. This stratifies the BOLD response to the CO2 ramp into four categories of CVR slope based on segmentation (type A; +/+slope: normal response, type B +/−, type C −/−: intracranial steal, type D −/+.) Types B to D represent altered responses to the CO2 stimulus.

RESULTS
Differential regional responsiveness was seen for both end-tidal gases. Hypocapnic regional CVR was more marked than hypercapnic CVR in 0.3% of voxels examined (P < 0.005, paired comparison); the converse occurred in 2.3% of voxels. For O2, mild hyperoxia had more marked CVR in 0.2% of voxels compared with greater hyperoxia; the converse occurred in 0.5% of voxels. All subjects had altered regional CO2 response based on Type Analysis ranging from 4 ± 2 to 7 ± 3% of voxels.

CONCLUSION
In awake subjects, regional differences and abnormalities in CVR were observed with changes in end-tidal gases common during the conduct of anaesthesia. On the basis of these findings, consideration could be given to minimising regional CVR fluctuations in patients-at-risk of neurological complications by tighter control of end-tidal gases near the individual's resting values.
Skin Cancer in People of Color
Authors: Shue-McGuffin Katherine D. , Powers Kelly 
Published: July 2022

ABSTRACT
People of color are at a lower risk for developing skin cancer; however, melanoma skin cancer in this population is associated with a high mortality rate. Misconceptions regarding skin cancer risk often delay treatment, contributing to negative outcomes. These misconceptions were evident in a nurse-practitioner-led project that was conducted at a Division I University to improve sun safety in female collegiate athletes, with a lack of sun safety knowledge noted among Black participants. Nurses and nurse practitioners have a pivotal role in preventing skin cancer in people of color. This article summarizes the project's findings and current literature to clarify misconceptions regarding skin cancer in people of color, specifically in Black individuals. Clinical information is provided to guide nurses and nurse practitioners in promoting awareness and early detection of skin cancer.
Metagenomic Thermometer
Authors: Kurokawa Masaomi , Higashi Koichi , Yoshida Keisuke , Sato Tomohiko , Maruyama Shigenori , Mori Hiroshi , Kurokawa Ken 
Published: July 2022

AbstractVarious microorganisms exist in environments, and each of which has an optimal growth temperature (OGT). The relationship between genomic information and OGT of each species has long been studied, and one such study revealed that OGT of prokaryotes can be accurately predicted based on the fraction of seven amino acids (IVYWREL) among all encoded amino-acid sequences in its genome. Extending this discovery, the fraction of IVYWREL among all amino acids encoded in the metagenomic DNA in an environment may reflect the environmental temperature to which the microorganisms have adapted. In the present study, we developed a ‘Metagenomic Thermometer’ as a means of predicting environmental temperature based on metagenomic sequences. Analysis of 41 metagenomic samples obtained from hot springs of varying temperature revealed that the Metagenomic Thermometer could indeed predict environmental temperature with high accuracy (R2 = 0.75). Although the taxonomic composition of microbial community was substantially affected by pH, the performance of the Metagenomic Thermometer was refractory to changes in community composition. The Metagenomic Thermometer was also applied to 616 human gut metagenomic samples, yielding a reasonably accurate value (i.e., 36.22 ± 1.98°C) for human body temperature. Our results suggest that environmental temperature can be predicted based on metagenomic sequence data.
Transcriptional profiling of hepatocytes infected with the replicative form of the malaria parasite Plasmodium cynomolgi
Authors: Mitchell Gabriel , Roma Guglielmo , Voorberg-van der Wel Annemarie , Beibel Martin , Zeeman Anne-Marie , Schuierer Sven , Torres Laura , Flannery Erika L , Kocken Clemens HM , Mikolajczak Sebastian A. , Diagana Thierry T. 
Published: July 2022

ABSTRACTThe zoonotic simian parasite Plasmodium cynomolgi develops into replicating schizonts and dormant hypnozoites during the infection of hepatocytes and is used as a model organism to study relapsing malaria. We previously reported the transcriptional profiling of P. cynomolgi liver stages and revealed many important biological features of the parasite (Bertschi et al., Elife, 2018; Voorberg-van der Wel et al., Elife, 2017) but left out the host response to malaria infection. Here, we used our published RNA sequencing data to quantify the expression of host genes in rhesus macaque hepatocytes infected with P. cynomolgi in comparison to either cells from uninfected samples or uninfected bystander cells. Although the dataset could not be used to resolve the transcriptional profile of hypnozoite-infected hepatocytes, it provided a snapshot of the host response to liver stage schizonts and identified specific host pathways that are modulated during malaria infection. This study constitutes a valuable resource characterizing the hepatocyte response to P. cynomolgi infection and provides a framework to build on future research that aims at understanding hepatocyte-parasite interactions during relapsing malaria infection.
Adeno-associated virus 2 infection in children with non-A-E hepatitis
Authors: Ho Antonia , Orton Richard , Tayler Rachel , Asamaphan Patawee , Tong Lily , Smollett Katherine , Davis Chris , Manali Maria , McDonald Sarah E. , Pollock Louisa , Evans Clair , McMenamin Jim , Roy Kirsty , Marsh Kimberly , Divala Titus , Holden Matt , Lockhart Michael , Yirrell David , Currie Sandra , Shepherd Samantha J. , Jackson Celia , Gunson Rory , MacLean Alasdair , McInnes Neil , Battle Richard , Hollenbach Jill , Henderson Paul , Chand Meera , Hamilton Melissa Shea , Estrada-Rivadeneyra Diego , Levin Michael ,   DIAMONDS consortium,   ISARIC4C Investigators, Robertson David L , Filipe Ana , Willett Brian , Breuer Judith , Semple Malcolm G , Turner David , Baillie J Kenneth , Thomson Emma C. 
Published: July 2022

Summary paragraphAn outbreak of acute hepatitis of unknown aetiology in children was first reported in Scotland in April 2022.1 Cases aged <16 years have since been identified in 35 countries.2 Here we report a detailed investigation of 9 early cases and 58 control subjects. Using next-generation sequencing and real-time PCR, adeno-associated virus 2 (AAV2), was detected in the plasma of 9/9 and liver of 4/4 patients but in 0/13 sera/plasma of age-matched healthy controls, 0/12 children with adenovirus (HAdV) infection and normal liver function and 0/33 children admitted to hospital with hepatitis of other aetiology. AAV2 typically requires a coinfecting ‘helper’ virus to replicate, usually HAdV or a herpesvirus. HAdV (species C and F) and human herpesvirus 6B (HHV6B) were detected in 6/9 and 3/9 affected cases, including 3/4 and 2/4 liver biopsies, respectively. The class II HLA-DRB1*04:01 allele was identified in 8/9 cases (89%), compared with a background frequency of 15.6% in Scottish blood donors, suggestive of increased susceptibility in affected cases. Acute non-A-E paediatric hepatitis is associated with the presence of AAV2 infection, which could represent a primary pathogen or a useful biomarker of recent HAdV or HHV6B infection. Population and mechanistic studies are required to explore these findings further.
Mapping of clusters about the relationship between e-government and corruption in Mexico
Authors: Cárdenas Cárdenas Gilberto , Vergara González Reyna 
Published: July 2022

Purpose
The purpose of this study is to analyze the impact of the e-goverment on corruption in Mexico. Mexico, although it has fought corruption from different angles, continues to be among the most corrupt countries in the world. One possible tool to reduce corruption, or at least so-called bureaucratic corruption, is e-government. There are studies that confirm an inverse relationship between e-government and corruption; as e-government increases, corruption decreases. The purpose of this research is to analyze the impact of the development of e-government (electronic portals) on corruption.

Design/methodology/approach
To achieve the stated objective, the authors have used econometrics (clusters) as the main methodology to obtain a possible confirmation of such inverse relationship between e-government and corruption in the 32 states that make up the country, for the period 2015–2019.

Findings
In the states that make up the Republic of Mexico, as the development of e-government increases, the corruption variable does not decrease. There is no significant relationship between these two variables.

Originality/value
The relationship between the variables e-government and corruption has been extensively studied in previous articles. However, in Latin America, studies on the impact of e-government on corruption are scarce, and at the Mexican national level are almost nonexistent.
The relationship between artificial intelligence (AI) and its aspects in higher education
Authors: Razia Bahaa , Awwad Bahaa , Taqi Najma 
Published: July 2022

Purpose
This paper aims to provide better understanding on this phenomenon, as well as some recommendations to assist in preparing Al technology and its related aspects during crisis like Covid period and beyond.

Design/methodology/approach
The study consisted of two phases. Phase one focused on identifying top higher education institutions according to the QS world university ranking. As a result, 180 higher education institutions in the Arab region were found, with the 2022 QS Arab region university ranking. The study selected top 20 performing institutions. Each institution has been assessed according to six metrics including: international student ratio, international research network, international ration, Web impact, citation per page and paper per faculty. Phase two explored the adapted Al applications and their related aspects that are used in each institution using a learning online questionnaire. Pilot tests were used to determine the validity and reliability of the measures.

Findings
Numerous factors that lead to enhancing high education using Artificial Intelligence in higher education institutions have emerged from this study. These factors include; knowledge management, trust, learning, technical resources and complexity. First, effective knowledge management assists in maintaining information in a place where it is easy to share and access. Second, trust is considered a critical factor in dealing with uncertainties like covid-19. It needs to be effectively addressed by students and staff members, especially in higher education. Without trust, decisions cannot be successfully made and actions may be delayed or stalled. Third, continuous learning is a key factor that tends to enhance the capability of dealing with new routines or potential challenges. Fourth, technical resources refer to electronic devices and tools that are used by students and academics to interact and share knowledge.

Originality/value
Students and faculty academics perceive things and use Al technology differently, which can lead to misunderstanding and create tension between them. Many higher education institutions have adapted great Al technology applications, but they are significantly less proficient than previously thought at understanding how to leverage this technology to produce helpful solutions to their business difficulties.
Fostering insights and improvements from IIoT systems at the shop floor: a case of industry 4.0 and lean complementarity enabled by action learning
Authors: Saabye Henrik , Powell Daryl John 
Published: July 2022

Purpose
This paper aims to investigate how manufacturers can foster insights and improvements from real-time data among shop-floor workers by developing organisational “learning-to-learn” capabilities based on both the lean- and action learning principle of learning through problem-solving. Second, the purpose is to extrapolate findings on how action learning can enable the complementarity between lean and industry 4.0.

Design/methodology/approach
An insider action research approach is adopted to investigate how manufacturers can enable their shop-floor workers to foster insights and improvements from real-time data at VELUX.

Findings
The findings report that enabling shop-floor workers to use real-time data consist of developing three consecutive organisational building blocks of learning-to-learn, learning-to-learn using real-time data and learning-to-learn generating real-time data − and helping others to learn (to learn).

Originality/value
First, the study contributes to theory and practice by demonstrating that a learning-to-learn capability is a core construct for manufacturers seeking to enable shop-floor workers to use real-time data-capturing systems to drive improvement. Second, the study outlines how lean and industry 4.0 complementarity can be enabled by action learning. Moreover, the study allows us to deduce six necessary conditions for enabling shop-floor workers to foster insights and improvements from real-time data.
Cultivating students’ sustainability-oriented learning at the interface of science and society: a configuration of interrelated enablers
Authors: Tassone Valentina C. , den Brok Perry , Tho Cassandra W.S. , Wals Arjen E.J. 
Published: July 2022

PurposeBy envisioning the learning environment as an eco-social system, this study aims to map interrelated enablers of students’ sustainability-oriented learning (SoL) in the context of a university course at the interface of science and society.Design/methodology/approachA case-study approach was used to delineate what enables student learning in a university-wide transdisciplinary Master of Science course. A sample of 102 students, university and societal stakeholders participated to this study, by sharing their experiences and views through focus groups and questionnaires.FindingsA main finding is the development of a configuration of six intertwined enablers that through their interplay help to cultivate students’ SoL, in the course under exploration.Originality/valueThis study paves the way for a re-orientation of how to explore learning in complex environments. It shows that adopting a relational, situated and systems approach is not only feasible but is also desirable to understand and guide learning practices in complex environments.
Twelve years of research in The International Journal of Islamic and Middle Eastern Finance and Management: a bibliometric analysis
Authors: Yihua Wu , Meng Fanchen , Farrukh Muhammad , Raza Ali , Alam Imtiaz 
Published: July 2022

Purpose
This study aims to analyze the International Journal of Islamic and Middle Eastern Finance and Management (IMEFM) publication structure based on broad criteria including citations, authors, institutions, countries, papers and keywords using the Scopus database over a period of 12 years.

Design/methodology/approach
In this paper, the bibliometric technique is used to analyze the advancement of IMEFM. Bibliometrics is a research field of library and information science that studies bibliographic material with quantitative methods.

Findings
The results show a steady increase in the citation and publication structure of the IMEFM. That reflects its developing stature as a key academic outlet. The journal is advancing knowledge in Islamic finance and management research.

Practical implications
This study presents a macro view of the journey of IMEFM over the past 12 years. That presents the audience with an opportunity to understand the trend and focus of the journal.

Originality/value
Bibliometric analysis contributed to the theoretical development of the IMEFM journal in the following ways. First, it describes the evolution and intellectual structure by identifying and classifying the most common themes in the journal. More specifically, this analysis underscores two important milestones: IMEFM has emerged as a robust academic outlet, and its comprehensive focus on Islamic finance and other related areas. Furthermore, the bibliometric analysis of IMEFM’s citations and knowledge stock pattern summarizes the scientific community contributing to its evolution and development. Finally, this study’s results offer future research directions.
The effect of knowledge sharing and systems thinking on organizational sustainability: the mediating role of creativity
Authors: Batool Fatima , Mohammad Jihad , Awang Siti Rahmah , Ahmad Tahir 
Published: July 2022

Purpose
The main purpose of this paper is to examine the direct effects of knowledge sharing and systems thinking on creativity and organizational sustainability in the hotel industry in Malaysia. In addition, the study aims to examine the mediation effect of creativity between knowledge sharing, systems thinking and organizational sustainability.

Design/methodology/approach
A survey method based on a questionnaire was used to gather data from 407 middle managers in the hotel industry in Malaysia. The partial least squares technique was used to examine the hypotheses.

Findings
The study found support for the effects of systems thinking and knowledge sharing on organizational sustainability. It also found support for the impact of creativity on organizational sustainability. Besides, the mediating role of creativity between systems thinking and organizational sustainability, and between knowledge sharing and organizational sustainability was also supported by data.

Originality/value
This is a pioneer work that has combined various human resources (i.e. systems thinking, knowledge sharing, creativity) to examine their impacts on organizational sustainability. Moreover, this work has established comparatively new relationships, i.e. the impact of systems thinking and knowledge sharing on creativity and organizational sustainability. In addition, the mediation role of creativity between systems thinking, knowledge sharing and organizational sustainability is relatively new in the literature. Furthermore, this study has confirmed the validity and reliability of knowledge sharing and organizational sustainability at first and second orders in the hotel industry in non-Western context.