bluuebunny/crossref_metadata_2025_split huggingface dataset:
FINANCIAMENTO EXTERNO EM APL: UMA ANÁLISE NO APL DE MÓVEIS DE MÁCEIO/AL
Authors: Lopes Carla Cristine Silva , Rocha Ronalty 
Published: February 2022

Diante das dificuldades enfrentadas pelas pequenas e médias empresas na obtenção de crédito, essa pesquisa endereçou a seguinte questão: quais barreiras e fatores limitantes impedem o acesso de empresas participantes de APL a financiamentos externos? Nesse cenário, esse estudo tem como objetivo discutir o acesso a financiamentos externos por empresas participantes do Arranjo Produtivo Local (APL) de Móveis de Maceió, Alagoas. Especificamente essa pesquisa buscou identificar as barreiras para prospectar apoio financeiro externo, descrever os fatores limitantes no acesso a crédito, assim como mencionar as ações de apoio desenvolvidas pela gestão do APL. Para alcance dos objetivo proposto foi realizada uma pesquisa qualitativa, por meio de um estudo de caso único integrado, cujas unidades de análise foram duas empresas participantes e a gerência do APL de Móveis de Maceió/AL. Os resultados indicam ampla diversidade de dificuldades enfrentadas pelas empresas, assim como o papel moderador exercido pela entidade gestora do arranjo.
Immersed In Pellet Technology: Motivation Paths of Innovative DIYers
Authors: Freeman Stephanie 
Published: February 2022

What drives and moves an individual towards certain goals and activities is a familiar question for scholars dealing with motivation in the context of schooling or (techno-scientific) work practices. However, non-school contexts such as Internet-enabled volunteer-based technical DIY communities are also important to understand since a growing part of everyday social life is spent on the Internet. This article offers the analytical concept of 'motivation path' for understanding changing and dilemmatic motives in innovative pellet DIY development. It also introduces the concept of 'innovative DIY' to show the blurring of the boundaries between profession/hobby and and past work life/retirement of technically competent, innovative people. The findings indicate that Internet-enabled making can be an important medium for continued personal growth, competence development, and (self) reflection. The findings could also help us understand how motivations may be carried over from professional work to private DIY work.
Landscape Degradation Processes and Implications in the Western Highlands of Cameroon
Authors: Akhere Gwan Solange , Kimengsi Jude Ndzifon , Nji Fogwe Zephania 
Published: February 2022

Globally landscape degradation has reignited renewed interest on the restoration of degraded landscapes across sub-Saharan Africa (SSA), including Cameroon. The aim of this article is to explore the processes and implications of landscape degradation in the south eastern part of the Western Highlands of Cameroon. Specifically, the paper sought to: (i) determine the triggers and pattern of landscape degradation, and (ii) analyse the socio-ecological effects of landscape degradation. The study employed a mixed-methods approach, involving a survey of 300 households, complemented by 7 focus group discussions and 22 key informant interviews to generate primary data. The data were analysed descriptively (using tables and charts) and inferentially using the binary logistic regression model. The results revealed that population growth, poor farming methods and the expansion of settlement are the three major factors contributing to landscape degradation in the area. It further shows thatprior to settlement, most of the land was used for farming – this further justifies the fact that (poor) farming methods significantly trigger landscape degradation. Additionally, landscape degradation has introduced significant effects in the western highlands to include the expensive use of soil additives, soil erosion and soil loss, the loss of soil fertility, among others. Finally, and informed by the binary logistic regression, population characteristics strongly determine the spatial pattern of landscape degradation in the Western Highlands than topographic traits. This that farmers should be encouraged to engage in organic farming to promote landscape restoration. Furthermore, the practice of slash and burn and ankara should be strongly discouraged amongst farming groups.
Nutrient Composition and Radical Scavenging Activities of Watermelon Seed-based Nutribar
Authors: Sekar Kavya , Kumara C. S. Shiva , Thabassum Z. Anees Fathima , Reddy M. Madhavi , Anandan Satish 
Published: February 2022

Aims: The present study is aimed to develop watermelon seed nutribars (WMSNB) and to determine proximate content, antioxidant activity, free fatty composition and also sensory evaluation in order to create awareness of its potential nutritional values and increase its consumption in the form of nutraceuticals, functional foods and pharmaceuticals.
Study Design: Proximate analysis, total phenolic, antioxidant activity and free fatty acid profile was carried by using well established in-vitro assay.
Place and Duration of the Study: Department of Clinical Nutrition and Dietetics, Sri Devaraj Urs Academy of Higher Education and Research. Kolar, between June 2021 and November 2021
Methodology: The developed nutribars samples were evaluated for proximate analysis (moisture, crude protein, ash, total fat, crude fibre, and total carbohydrate), total phenolic, antioxidant activity by using DPPH assay, free fatty composition by using GC-MS, and sensory characteristics based on hedonic scale point. The ingredients used for preparation of WMSNB were Watermelon seeds (100gm), jaggery (50gm), coconut flakes (15gm), sesame seeds (10gm) and ghee (5gm). Peanut nutribars (PNB) were also developed by replacing Watermelon seeds (WMS) with peanuts which was used for comparison purpose.
Results: The proximate screening indicated that protein (15.72%) and carbohydrate content (52.49%) was high in WMSNB compared to PNB. The prepared WMSNB showed rich in phenolics and also possessed good antioxidant activity against DPPH. The free fatty acid composition showed that linolenic acid, stearic acid and lauric acid of oil extracted from WMSNB were 51.15%, 10.65% and 6.49% respectively, while oleic and palmitic acid extracted from PNB were 38.11% and 14.62% respectively. The overall sensory evaluation showed that there was no significant difference (P<0.05) between WMSNB and PNB.
Conclusion: The antioxidant capacity of the WMSNB constituent underlines the potential source of natural antioxidants and bioactive compounds for the therapeutic purposes.
To Evaluate the Practices and Attitude Regarding the Material of Choice and Method amongst Dentist for Repair of Defective Restoration of Tooth in Vidarbha: A Cross Sectional Study
Authors: Madhu Priyanka Paul , Chhabra Kumar Gaurav , Dhotkar Vaishnavi , Chandiwale Sumedha , Sheikha Alfiya 
Published: February 2022

Background: The findings of this study will help dental care professionals reach out to the material of choice in more meaningful ways by catering to a list of potential reasons that will determine the selection of material for repair restorations based on its longevity, strength and knowledge of dental professionals of Vidarbha.
Objective: 1. To evaluate the practices regarding material of choice and method amongst dentist for repair of defective restoration of tooth.

To evaluate the attitude regarding material of choice and method amongst dentist for repair of defective restoration of tooth.
To correlate the practices and attitude regarding material of choice and method amongst dentist for repair of defective restoration of tooth.

Methodology: An online based cross sectional questionnaire study will be conducted by assessing the responses to 15 selected questions regarding carried assessment of the practice and attitude about reparative restorations among dental professionals of Vidarbha Region. The aspect on which results will be analyzed is the preferred material by dentists for reparative restoration. The questionnaire will be distributed amongst dental health professionals and their responses will be recorded along with validation of questionnaire. A convenient sampling method has been applied in the cross-sectional study depending upon the responses received after the survey. The results will be determined based on response on material selection and its longevity.
Survey Procedure: questions will be asked by online platform to dental health professionals with explanation of purpose of the study. The questions will be both open and close end type.
Expected Results: The expected result of the study will determine preferred material of choice and method for repair of defective restoration amongst dental health professionals of Vidarbha.
Conclusion: There are many key factors that affect the regarding material of choice and method amongst dentist for repair of defective restoration of tooth. Hence this study will evaluate material of choice and method amongst dentist for repair of defective restoration of tooth.
Error tracking approach to discrete‐time adaptive iterative learning control against arbitrary initial perturbations
Authors: Sun Mingxuan , Zhan Yizhao , Li Wei , He Xiongxiong 
Published: February 2022

SummaryInitial condition problem is crucial to a conventional iterative learning control (ILC) scheme, which steers the tracking error from arbitrary initial value to zero in the time steps equaling to the relative degree of the system undertaken. The implementation may be difficult, due to the practical limitation for the control amplitude. This paper presents an error‐tracking approach to discrete‐time adaptive ILC designs for tracking nonidentical tasks in the presence of initial repositioning errors, which may be quite large. A prototype iterative learning algorithm is derived for estimating the time‐varying unknowns, and the saturation is introduced for assuring the estimates to keep away from zero. A key technical lemma, tailored for the analysis purpose in the iteration domain, is presented and applied to analysis of the ILC scheme. The tracking performance of the closed‐loop system is evaluated and explored in detail. It is shown that the perfect tracking for the error between the tracking error and the desired error is achieved at every time instant, while the input and output signals remain bounded. By the simulation example, the proposed scheme is verified to be applicable to tracking tasks without restriction on initial repositioning.
Development of Tri‐Layered Biomimetic Atelocollagen Scaffolds with Interfaces for Osteochondral Tissue Engineering
Authors: Cao Runfeng , Xu Yang , Xu Yong , Brand D. D. , Zhou Guangdong , Xiao Kaiyan , Xia Huitang , Czernuszka J. T. 
Published: February 2022

AbstractThe development of biomimetic scaffolds containing cartilage, calcified cartilage, and bone regeneration for precise osteochondral repair remains a challenge. Herein, a novel tri‐layered scaffold—with a top layer containing type II atelocollagen and chondroitin sulphate for cartilage regeneration, an intermediate layer with type II atelocollagen and hydroxyapatite for calcified cartilage formation, and a bottom layer with type I atelocollagen and hydroxyapatite for bone growth—that can be built using liquid‐phase cosynthesis, is described. The tri‐layered scaffolds are mechanically demonstrably superior and have a lower risk of delamination than monolayer scaffolds. This is due to higher cohesion arising from the interfaces between each layer. In vitro results show that although monolayer scaffolds can stimulate bone marrow stem cells to differentiate and form cartilage, calcified cartilage, and bone separately (detected using quantitative polymerase chain reaction analysis and staining with safranin‐O and Alizarin Red S), the tri‐layered scaffolds support the regeneration of cartilage, calcified cartilage, and bone simultaneously after 2 and 4 months of implantation (detected using gross and micro‐computed tomography images, histological staining, and Avizo, a software used to detect microlevel defects in metals). This work presents data on a promising approach in devising strategies for the precise repair of osteochondral defects.
Antibacterial Sericin Cryogels Promote Hemostasis by Facilitating the Activation of Coagulation Pathway and Platelets
Authors: Zhu Yuanyuan , Liu Huan , Qin Sumei , Yang Cheng , Lv Qiying , Wang Zheng , Wang Lin 
Published: February 2022

AbstractCryogels, with high water/blood absorption, have great potential for rapid hemostasis. In this study, a hemostatic and antibacterial sericin‐methacryloyl/Ag cryogel (SMC@Ag) based on freeze polymerization of methacryloyl‐modified sericin and in situ reduction of silver ions is developed. The combination of interconnected micropores and Ag NPs endows the cryogel with high water/blood absorption, and outstanding hemostatic and antibacterial performance. SMC@Ag shows much better hemostatic performance than the commercial gelatin sponge in rat liver injury, tail amputation, and femoral artery injury models. Furthermore, the excellent hemostatic activity of SMC@Ag is due to facilitating the coagulation pathway activation and enhancing the platelets adhesion during coagulation process. Overall, SMC@Ag cryogel with excellent hemostatic and antibacterial performance is a suitable candidate for traumatic hemorrhage and wound healing.
Tuning Two‐Electron Oxygen‐Reduction Pathways for H2O2 Electrosynthesis via Engineering Atomically Dispersed Single Metal Site Catalysts
Authors: Yang Xiaoxuan , Zeng Yachao , Alnoush Wajdi , Hou Yang , Higgins Drew , Wu Gang 
Published: February 2022

AbstractThe hydrogen peroxide (H2O2) generation via the electrochemical oxygen reduction reaction (ORR) under ambient conditions is emerging as an alternative and green strategy to the traditional energy‐intensive anthraquinone process and unsafe direct synthesis using H2 and O2. It enables on‐site and decentralized H2O2 production using air and renewable electricity for various applications. Currently, atomically dispersed single metal site catalysts have emerged as the most promising platinum group metal (PGM)‐free electrocatalysts for the ORR. Further tuning their central metal sites, coordination environments, and local structures can be highly active and selective for H2O2 production via the 2e− ORR. Herein, recent methodologies and achievements on developing single metal site catalysts for selective O2 to H2O2 reduction are summarized. Combined with theoretical computation and advanced characterization, a structure–property correlation to guide rational catalyst design with a favorable 2e− ORR process is aimed to provide. Due to the oxidative nature of H2O2 and the derived free radicals, catalyst stability and effective solutions to improve catalyst tolerance to H2O2 are emphasized. Transferring intrinsic catalyst properties to electrode performance for viable applications always remains a grand challenge. The key performance metrics and knowledge during the electrolyzer development are, therefore, highlighted.
Engineering Macrophage Exosome Disguised Biodegradable Nanoplatform for Enhanced Sonodynamic Therapy of Glioblastoma
Authors: Wu Tingting , Liu Ying , Cao Yu , Liu Zhihong 
Published: February 2022

AbstractSonodynamic therapy (SDT) exhibits high tissue penetration and negligible radiation damage to normal tissues, and thus emerges as a promising cancer therapeutic modality for glioblastoma (GBM). However, the blood−brain barrier (BBB) and hypoxic microenvironment greatly limit the SDT efficiency. In this work, a biodegradable nanoplatform (termed as CSI) is fabricated by encapsulating catalase (CAT) into silica nanoparticles (CAT@SiO2) for tumor hypoxia relief, and then loaded with the sonosensitizer indocyanine green (ICG). Inspired by the ability of macrophages to cross the BBB, CSI is further coated with AS1411 aptamer‐modified macrophage exosomes to form CSI@Ex‐A, which possesses efficient BBB penetration and good cancer‐cell‐targeting capability. After tumor cell endocytosis, highly expressed glutathione (GSH) triggeres biodegradation of the nanoplatform and the released CAT catalyzes hydrogen peroxide (H2O2) to produce O2 to relieve tumor hypoxia. The GSH depletion and O2 self‐supplying effectively enhances the SDT efficiency both in vitro and in vivo. In addition, the resulting CSI@Ex‐A exhibits good biocompatibility and long circulation time. These findings demonstrate that CSI@Ex‐A may serve as a competent nanoplatform for GBM therapy, with potential for clinical translation.
Ultrafast Spin‐Charge Conversion at SnBi2Te4/Co Topological Insulator Interfaces Probed by Terahertz Emission Spectroscopy
Authors: Rongione E. , Fragkos S. , Baringthon L. , Hawecker J. , Xenogiannopoulou E. , Tsipas P. , Song C. , Mičica M. , Mangeney J. , Tignon J. , Boulier T. , Reyren N. , Lebrun R. , George J.‐M. , Le Fèvre P. , Dhillon S. , Dimoulas A. , Jaffrès H. 
Published: February 2022

AbstractSpin‐to‐charge conversion (SCC) involving topological surface states (TSS) is one of the most promising routes for highly efficient spintronic devices for terahertz (THz) emission. Here, the THz generation generally occurs mainly via SCC consisting in efficient dynamical spin injection into spin‐locked TSS. In this work, sizable THz emission from a nanometric thick topological insulator (TI)/ferromagnetic junction—SnBi2Te4/Co—specifically designed to avoid bulk band crossing with the TSS at the Fermi level, unlike its parent material Bi2Te3 is demonstrated. THz emission time domain spectroscopy (TDS) is used to indicate the TSS contribution to the SCC by investigating the TI thickness and angular dependence of the THz emission. This work illustrates THz emission TDS as a powerful tool alongside angular resolved photoemission spectroscopy (ARPES) methods to investigate the interfacial spintronic properties of TI/ferromagnet bilayers.
Estimating mortality from coal workers' pneumoconiosis among Medicare beneficiaries with pneumoconiosis using binary regressions for spatially sparse data
Authors: Paul Rajib , Adeyemi Oluwaseun , Arif Ahmed A. 
Published: February 2022

AbstractBackgroundCoal workers' pneumoconiosis (CWP) is an occupational lung disease due to inhalation of coal dust. We estimated mortality from CWP and other pneumoconioses among Medicare beneficiaries.MethodsWe used the 5% Medicare Limited Claims Data Set, 2011–2014, to identify patients diagnosed with ICD‐9‐CM 500 (CWP) through 505 (Asbestosis, Pneumoconiosis due to other silica or silicates, Pneumoconiosis due to other inorganic dust, Pneumonopathy due to inhalation of other dust, and Pneumoconiosis, unspecified) codes. We applied binary regression models with spatial random effects to determine the association between CWP and mortality. Our inferences are based on Bayesian spatial hierarchical models, and model fitting was performed using Integrated Nested Laplace Approximation (INLA) algorithm in R/RStudio software.ResultsThe median age of the sample was 76 years. In a sample of 8531 Medicare beneficiaries, 2568 died. Medicare beneficiaries with CWP had 25% higher odds of death (adjusted OR: 1.25, 95% CI: 1.07, 1.46) than those with other types of pneumoconiosis. The number of comorbid conditions elevated the odds of death by 10% (adjusted OR: 1.10, 95% CI: 1.09, 1.10).ConclusionCWP increases the likelihood of death among Medicare beneficiaries. Healthcare professionals should make concerted efforts to monitor patients with CWP to prevent premature mortality.
A Nuclear‐Targeted AIE Photosensitizer for Enzyme Inhibition and Photosensitization in Cancer Cell Ablation
Authors: Wang Kang‐Nan , Liu Liu‐Yi , Mao Duo , Hou Ming‐Xuan , Tan Cai‐Ping , Mao Zong‐Wan , Liu Bin 
Published: February 2022

AbstractThe nucleus is considered the ideal target for anti‐tumor therapy because DNA and some enzymes in the nucleus are the main causes of cell canceration and malignant proliferation. However, nuclear target drugs with good biosafety and high efficiency in cancer treatment are rare. Herein, a nuclear‐targeted material MeTPAE with aggregation‐induced emission (AIE) characteristics was developed based on a triphenylamine structure skeleton. MeTPAE can not only interact with histone deacetylases (HDACs) to inhibit cell proliferation but also damage telomere and nucleic acids precisely through photodynamic treatment (PDT). The cocktail strategy of MeTPAE caused obvious cell cycle arrest and showed excellent PDT anti‐tumor activity, which offered new opportunities for the effective treatment of malignant tumors.
Versatile Construction of Biomimetic Nanosensors for Electrochemical Monitoring of Intracellular Glutathione
Authors: Wu Wen‐Tao , Chen Xi , Jiao Yu‐Ting , Fan Wen‐Ting , Liu Yan‐Ling , Huang Wei‐Hua 
Published: February 2022

AbstractThe current strategies for nanoelectrode functionalization usually involve sophisticated modification procedures, uncontrollable and unstable modifier assembly, as well as a limited variety of modifiers. To address this issue, we propose a versatile strategy for large‐scale synthesis of biomimetic molecular catalysts (BMCs) modified nanowires (NWs) to construct functionalized electrochemical nanosensors. This design protocol employs an easy, controllable and stable assembly of diverse BMCs‐poly(3,4‐ethylenedioxythiophene) (PEDOT) composites on conductive NWs. The intrinsic catalytic activity of BMCs combined with outstanding electron transfer ability of conductive polymer enables the nanosensors to sensitively and selectively detect various biomolecules. Further application of sulfonated cobalt phthalocyanine functionalized nanosensors achieves real‐time electrochemical monitoring of intracellular glutathione levels and its redox homeostasis in single living cells for the first time.
MOF‐Hosted Enzymes for Continuous Flow Catalysis in Aqueous and Organic Solvents
Authors: Greifenstein Raphael , Ballweg Tim , Hashem Tawheed , Gottwald Eric , Achauer David , Kirschhöfer Frank , Nusser Michael , Brenner‐Weiß Gerald , Sedghamiz Elaheh , Wenzel Wolfgang , Mittmann Esther , Rabe Kersten S. , Niemeyer Christof M. , Franzreb Matthias , Wöll Christof 
Published: February 2022

AbstractFully exploiting the potential of enzymes in cell‐free biocatalysis requires stabilization of the catalytically active proteins and their integration into efficient reactor systems. Although in recent years initial steps towards the immobilization of such biomolecules in metal–organic frameworks (MOFs) have been taken, these demonstrations have been limited to batch experiments and to aqueous conditions. Here we demonstrate a MOF‐based continuous flow enzyme reactor system, with high productivity and stability, which is also suitable for organic solvents. Under aqueous conditions, the stability of the enzyme was increased 30‐fold, and the space–time yield exceeded that obtained with other enzyme immobilization strategies by an order of magnitude. Importantly, the infiltration of the proteins into the MOF did not require additional functionalization, thus allowing for time‐ and cost‐efficient fabrication of the biocatalysts using label‐free enzymes.