bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Peritumorally Injected Immunomodulating Adjuvant Elicits Robust and Safe Metalloimmunotherapy against Solid Tumors
Authors: Zhang Lingxiao , Zhao Jing , Hu Xi , Wang Chenhan , Jia Yingbo , Zhu Chaojie , Xie Shangzhi , Lee Jiyoung , Li Fangyuan , Ling Daishun 
Published: August 2022

AbstractClinical immunotherapy of solid tumors elicits durable responses only in a minority of patients, largely due to the highly immunosuppressive tumor microenvironment (TME). Although rational combinations of vaccine adjuvants with inflammatory cytokines or immune agonists that relieve immunosuppression represent an appealing therapeutic strategy against solid tumors, there are unavoidable nonspecific toxicities due to the pleiotropy of cytokines and undesired activation of off‐target cells. Herein, a Zn2+ doped layered double hydroxide (Zn‐LDH) based immunomodulating adjuvant, which not only relieves immunosuppression but also elicits robust antitumor immunity, is reported. Peritumorally injected Zn‐LDH sustainably neutralizes acidic TME and releases abundant Zn2+, promoting a pro‐inflammatory network composed of M1‐tumor‐associated macrophages, cytotoxic T cells, and natural‐killer cells. Moreover, the Zn‐LDH internalized by tumor cells effectively disrupts endo‐/lysosomes to block autophagy and induces mitochondrial damage, and the released Zn2+ activates the cGas‐STING signaling pathway to induce immunogenic cell death, which further promotes the release of tumor‐associated antigens to induce antigen‐specific cytotoxic T lymphocytes. Unprecedentedly, merely injection of Zn‐LDH adjuvant, without using any cytotoxic inflammatory cytokines or immune agonists, significantly inhibits the growth, recurrence, and metastasis of solid tumors in mice. This study provides a rational bottom‐up design of potent adjuvant for cancer metalloimmunotherapy against solid tumors.
MAB‐Phases and Beyond—A Tribological Success Story?
Authors: Rosenkranz Andreas , Zambrano Dario , Przyborowski Alexandra , Shah Raj , Jastrzębska Agnieszka Maria 
Published: August 2022

AbstractEarly transition metal borides (MAB‐phases) are extensively investigated due to their excellent mechanical and tribological properties. These characteristics of ternary transition metal borides have created a promising pathway to achieve strong materials with unique properties. These layered materials combine both metallic and ceramic attributes and possess intriguing properties such as excellent mechanical, chemical, and thermal stability. Most of the MAB‐phases were discovered before the 1990s, but recent discoveries of their derivatives, such as i‐MAB phases, and MBenes, have boosted their “renaissance.” Altogether, this perspective summarizes the existing state‐of‐the‐art regarding the tribological performance of the most promising MAB‐phases and further discusses their success story in potential applications. Since the story of their derivative phases regarding mechanical/tribological applications has just begun, going beyond MAB‐phases is highly promising to explore novel high‐strength materials.
Positively Charged Poly(Piperazinamide) Nanofiltration Membranes for the Fast Removal of Metal Ions
Authors: Liu Ying , Kong Jinfeng , Bian Xiangying , Zhang Yuping , Ji Miaozhou , Peng Quan , Jin Jian , Zhu Yuzhang 
Published: August 2022

AbstractPositively charged nanofiltration (NF) membranes with high perm‐selectivity are highly desired to remove divalent cations such as Ca2+ and Mg2+ ions to ensure the safety of domestic and industrial water supply. In this work, a poly(piperazinamide) NF membrane with a positively charged surface is fabricated via the surfactant‐assembly regulated interfacial polymerization (SARIP) of piperazine (PIP) and 1,3,5‐trimesoyl chloride (TMC). The surfactant assembly can accelerate PIP monomer into the hexane to react with TMC monomer, thus reducing the difference in the trans‐interface diffusion of PIP and the diffusion of TMC in hexane, forming an interfacial polymerization with a stoichiometric characteristic. By tuning the concentration ratio of PIP and TMC, a positively charged poly(piperazinamide) NF membrane will be achieved. At the same time, utilizing the superior hydrophilicity of bacterial cellulose nanofibers nanofilm, a crumpled poly(piperazinamide) active layer is successfully constructed, resulting in a permeating flux up to 22 L m−2 h−1 bar−1 and simultaneously with a MgCl2 rejection >96%. The performance of this positively charged poly(piperazinamide) NF membrane is superior to most other positive NF membranes for the removal of divalent cations so far.
Paying Comprehensive Attention to the ESPT Mechanism and Luminescent Property of Salicylic Acid and Its Derivatives in Various Microenvironments
Authors: Shang Changjiao , Cao Yunjian , Zhang Yajie , Ma Min , Sun Chaofan 
Published: August 2022

AbstractInvestigating the effects of surrounding microenvironments and substituents on the excited‐state proton transfer (ESPT) mechanism have always been a great challenge, especially in protic solvents and solid state. In this work, a detailed theoretical study on ESPT processes of salicylic acid (SA) and its two derivatives (5ASA and 5NSA) in gas, cyclohexane, acetonitrile, ethanol (EtOH), and crystal phases is performed based on the density functional theory (DFT) and time‐dependent DFT as well as the combined quantum mechanics/molecular mechanics (QM/MM) methods. Intramolecular charge transfer‐induced aggregation‐caused quenching phenomenon of 5ASA is unveiled utilizing the hole–electron analysis. Independent gradient model analysis is implemented to reveal the spontaneous forward proton transfer (PT) behavior of 5ASA. Besides, potential energy surfaces are constructed to evaluate the dominant PT pathway in EtOH, and the related transition state structures are also obtained to accurately provide the intra‐ and inter‐PT energy barriers. Eventually, excited‐state ab initio molecular dynamics computation reaffirms that the intra‐PT reaction is predominant for SA. This theoretical work comprehensively explores the ESPT mechanism and luminescent properties of SA and its two derivatives, which provides a reference for developing efficient organic light‐emitting materials based on ESPT chromophores.
Single‐Nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma
Authors: Ou Zhihua , Lin Shitong , Qiu Jiaying , Ding Wencheng , Ren Peidi , Chen Dongsheng , Wang Jiaxuan , Tong Yihan , Wu Di , Chen Ao , Deng Yuan , Cheng Mengnan , Peng Ting , Lu Haorong , Yang Huanming , Wang Jian , Jin Xin , Ma Ding , Xu Xun , Wang Yanzhou , Li Junhua , Wu Peng 
Published: August 2022

AbstractThe effective treatment of advanced cervical cancer remains challenging. Herein, single‐nucleus RNA sequencing (snRNA‐seq) and SpaTial enhanced resolution omics‐sequencing (Stereo‐seq) are used to investigate the immunological microenvironment of cervical squamous cell carcinoma (CSCC). The expression levels of most immune suppressive genes in the tumor and inflammation areas of CSCC are not significantly higher than those in the non‐cancer samples, except for LGALS9 and IDO1. Stronger signals of CD56+ NK cells and immature dendritic cells are found in the hypermetabolic tumor areas, whereas more eosinophils, immature B cells, and Treg cells are found in the hypometabolic tumor areas. Moreover, a cluster of pro‐tumorigenic cancer‐associated myofibroblasts (myCAFs) are identified. The myCAFs may support the growth and metastasis of tumors by inhibiting lymphocyte infiltration and remodeling of the tumor extracellular matrix. Furthermore, these myCAFs are associated with poorer survival probability in patients with CSCC, predict resistance to immunotherapy, and might be present in a small fraction (< 30%) of patients with advanced cancer. Immunohistochemistry and multiplex immunofluorescence staining are conducted to validate the spatial distribution and potential function of myCAFs. Collectively, these findings enhance the understanding of the immunological microenvironment of CSCC and shed light on the treatment of advanced CSCC.
Multi‐Degree‐of‐Freedom Robots Powered and Controlled by Microwaves
Authors: Li Yongze , Wu Jianyu , Yang Peizhuo , Song Lizhong , Wang Jun , Xing Zhiguang , Zhao Jianwen 
Published: August 2022

AbstractMicrowaves have become a promising wireless driving strategy due to the advantages of transmissivity through obstacles, fast energy targeting, and selective heating. Although there are some studies on microwave powered artificial muscles based on different structures, the lack of studies on microwave control has limited the development of microwave‐driven (MWD) robots. Here, a far‐field MWD parallel robot controlled by adjusting energy distribution via changing the polarization direction of microwaves at 2.47 GHz is first reported. The parallel robot is based on three double‐layer bending actuators composed of wave‐absorbing sheets and bimetallic sheets, and it can implement circular and triangular path at a distance of 0.4 m under 700 W transmitting power. The thermal response rate of the actuator under microwaves is studied, and it is found that the electric‐field components can provide a faster thermal response at the optimal length of actuator than magnetic‐field components. The work of the parallel robot is demonstrated in an enclosed space composed of microwave‐transparent materials. This developed method demonstrates the multi‐degree‐of‐freedom controllability for robots using microwaves and offers potential solutions for some engineering cases, such as pipeline/reactors inspection and medical applications.
Self‐Derivation and Surface Reconstruction of Fe‐Doped Ni3S2 Electrode Realizing High‐Efficient and Stable Overall Water and Urea Electrolysis
Authors: Li Derun , Wan Wenjing , Wang Zhaowu , Wu Hengyi , Wu Shixin , Jiang Tao , Cai Guangxu , Jiang Changzhong , Ren Feng 
Published: August 2022

AbstractExploring earth‐abundant, highly effective, and stable electrocatalysts for overall water and urea electrolysis is urgent and essential for developing hydrogen energy technology. Herein, a simple self‐derivation method is used to fabricate a Fe‐doped Ni3S2 electrode. The electrode exhibits an impressive trifunctional catalyst, with low overpotentials of 290, 198, and 254 mV at 100 mA cm−2 for the oxygen evolution reaction (OER), urea oxidation reaction (UOR), and hydrogen evolution reaction (HER). The durability is higher than 3500 h (146 days) at 100 mA cm−2 for the OER without obvious change. In situ Raman spectra reveal the incorporation of Fe inhibited S dissolution and facilitates the catalyst reconstruction. The density functional theory calculations indicate that the doping of Fe optimizes the adsorption of the rate‐determining step and the d‐band center is closer to the Fermi level, which accelerates the OER process. The two‐electrode electrolyzer needs the cell voltages of only 1.76 and 1.57 V to achieve a current density of 100 mA cm−2 and remarkable durability for more than 500 h at 100 and 500 mA cm−2 for overall water and urea splitting. This work holds great promise for industrial water and urea splitting applications.
Inadequate energy and protein intake, underweight and malnutrition are associated with in‐hospital mortality among COVID‐19 rehabilitation patients during the omicron outbreak in Hong Kong
Authors: Ting Terry Ho Yan , Lo Tiffany Hoi Man , Lo Winnie Wing Tung , Ding Qi , Yuk Daniel Ka Lok , Hui Elsie , Tang Maria Wing Sze 
Published: August 2022

AbstractObjectiveMalnourished COVID‐19 patients were prone to higher mortality and longer length of stay (LOS). This study aims to investigate the malnutrition risk prevalence in the COVID‐19 patients and how other nutritional indicators are related to the clinical outcomes in a rehabilitation hospital.MethodsA retrospective cross‐sectional study involved 174 COVID‐19 patients during the rehabilitation phase. Malnutrition risk, nutritional indicators, mortality, and LOS were compared among different risk groups. Albumin, nutrition intake, and body mass index (BMI) were investigated for their effects on the clinical outcomes.ResultsThe prevalence of malnutrition risk was 94.9%; those older were higher in malnutrition risk. BMI, energy and protein intakes decreased as the malnutrition risk increased. Albumin, energy and protein intakes were lower in the death group. The high malnutrition risk group and severely underweight patients had 2.7 times and 2.2 times higher in‐hospital death, respectively. For subjects ≥75 years old, the odds ratio to death was 6.2 compared to those <75 years old.ConclusionWe observed a high malnutrition risk of 94.9% in COVID‐19 patients. Patients with malnutrition risk had a lower BMI, lower nutritional intake, and a higher chance of in‐hospital death. These results reinforced the importance of nutrition management in COVID‐19 patients.
Reliability of O*NET physical exposures between Italian and US databases
Authors: d'Errico Angelo , Gallo Francesca , Evanoff Bradley A. , Descatha Alexis , Dale Ann M. 
Published: August 2022

AbstractBackgroundComparison between cross‐national job‐exposure matrices (JEMs) may provide indications of their reliability, particularly if created using the same items. This study evaluated concordance between two JEMs created from United States (US) and Italian O*NET data, using job codes linked through international job codes.MethodsTwenty‐one physical exposures were obtained from the US and Italian O*NET databases. Italian O*NET items were direct translations of US O*NET items. Six hundred and eighty‐four US and 586 Italian job codes were linked via crosswalks to 281 ISCO‐08 job codes. A sensitivity study also assessed concordance on 258 jobs matched one‐to‐one across the two national job classifications. Concordance of US and Italian O*NET exposures was estimated by intraclass correlation coefficients (ICC) in multilevel models adjusted and not adjusted for country.ResultsICCs showed moderate to poor agreement for all physical exposures in jobs linked through ISCO‐08 codes. There was good to moderate agreement for 14 out of 21 exposures in models with one‐to‐one matched jobs between countries; greater agreement was found in all models adjusted for country. Exposure to whole‐body vibration, time standing, and working outdoor exposed to weather showed the highest agreement.ConclusionsThese results showed moderate to good agreement for most physical exposures across the two JEMs when US and Italian jobs were matched one‐to‐one and the analysis was adjusted for country. Job code assignments through crosswalks and differences in exposure levels between countries might greatly influence the observed cross‐country agreement. Future multinational epidemiological studies should consider the quality of the cross‐national job matching, and potential cross‐national differences in exposure levels.
Predicting Impulse Control Disorders in Parkinson Disease through Incentive Biomarkers
Authors: Marín‐Lahoz Juan , Martinez‐Horta Saül , Pagonabarraga Javier , Horta‐Barba Andrea , Aracil‐Bolaños Ignacio , Bejr‐kasem Helena , Sampedro Frederic , Campolongo Antonia , Kulisevsky Jaime 
Published: August 2022

ObjectiveThis study was undertaken to evaluate whether the feedback‐related negativity (FRN)—a neurophysiological marker of incentive processing—can be used to predict the development of impulse control disorders (ICDs) in Parkinson disease (PD).MethodsThe longitudinal cohort consisted of consecutive nondemented PD patients with no ICD history. We recorded FRN signals while they performed a gambling task. We calculated the mean amplitude difference between losses and gains (FRNdiff) to be used as a predictor of future ICD development. We performed prospective biannual follow‐up assessments for 30 months to detect incident ICDs. Finally, we evaluated how basal FRNdiff was associated with posterior development of ICDs using survival models.ResultsBetween October 7, 2015 and December 16, 2016, we screened 120 patients. Among them, 94 patients performed the gambling and 92 completed the follow‐up. Eighteen patients developed ICDs during follow‐up, whereas 74 remained free of ICDs. Baseline FRNdiff was greater in patients who developed ICDs than in those who did not (−2.33μV vs −0.84μV, p = 0.001). No other significant baseline differences were found. The FRNdiff was significantly associated with ICD development in the survival models both when not adjusted (hazard ratio [HR] = 0.73, 95% confidence interval [CI] = 0.58–0.91, p = 0.006) and when controlling for dopamine replacement therapy, sex, and age (HR = 0.74, 95% CI = 0.55–0.97, p = 0.035). None of the impulsivity measures evaluated was related to ICD development.InterpretationReward‐processing differences measured by FRN signals precede ICD development in PD. This neurophysiological marker permits identification of patients with high risk of ICD development. ANN NEUROL 2022;92:974–984
A Deprotection‐free Method for High‐yield Synthesis of Graphdiyne Powder with In Situ Formed CuO Nanoparticles
Authors: Li Jian , Han Xu , Wang Dongmei , Zhu Lei , Ha‐Thi Minh‐Huong , Pino Thomas , Arbiol Jordi , Wu Li‐Zhu , Nawfal Ghazzal Mohamed 
Published: August 2022

AbstractWith a direct band gap, superior charge carrier mobility, and uniformly distributed pores, graphdiyne (GDY) has stimulated tremendous interest from the scientific community. However, its broad application is greatly limited by the complicated multistep synthesis process including complex deprotection of hexakis‐[(trimethylsilyl)ethynyl]benzene (HEB‐TMS) and peeling of GDY from the substrates. Here, we describe a deprotection‐free strategy to prepare GDY powder by directly using HEB‐TMS as the monomer. When CuCl was used as the catalysts in DMF solvent, the yield of GDY powder reached ≈100 %. More interestingly, uniformly dispersed CuO nanoparticles with an average diameter of ≈2.9 nm were in situ formed on GDY after the reaction. The prepared CuO/GDY was demonstrated an excellent co‐catalyst for photocatalytic hydrogen evolution, comparable to the state‐of‐art Pt co‐catalyst. The deprotection‐free approach will widen the use of GDY and facilitate its scaling up to industrial level.
Metal‐Free Aminocarbonylation of p‐Quinone Methides with Isocyanides: Synthesis of Sterically Hindered α‐Arylated Acetamides
Authors: Shirsath Sachin R. , More Devidas A. , Muthukrishnan M. 
Published: August 2022

AbstractThe synthesis of sterically hindered α‐arylated acetamides generally requires a multistep reaction sequence and is also difficult to access due to steric constraints. This protocol allows the synthesis of sterically hindered α‐arylated acetamides in moderate to high yields via 1,6‐addition of isocyanides to p‐quinone methides in the presence of BF3.OEt2. The present transformation features transition metal‐free conditions, avoiding the use of toxic carbon monoxide, broad substrate scope, mild reaction conditions, and operational simplicity.
Chlorine Substitution in Spirocyclic Derivatives Triggers SHG Response in Noncentrosymmetric Crystal
Authors: Gao Hong , Zhang Tie , Lun Meng‐Meng , Li Jun‐Yi , Lu Hai‐Feng , Fu Da‐Wei , Zhang Yi 
Published: August 2022

AbstractOrganic‐inorganic hybrid phase transition materials with switchable properties have important potential applications in smart devices such as dielectric switches and storage. Nevertheless, it remains challenging to modify molecular structures efficiently to obtain materials simultaneously possessing multiple responsive properties. Herein, different from ordinary halogen substitutions in Metal Halide, we report a halogen regulation design of organic molecular strategy: (ASD)2MnBr4 (ASD=5‐azonia‐spiro [4.5] decane) to (CASD)2MnBr4 (CASD=8‐chloro‐5‐azonia‐spiro [4.5] decane). After organic molecular halogen regulation, the SHG response was excited and the dielectric phase transition temperature (Tc) has also been greatly improved. Furthermore, under the irradiation of UV lamp, both showed green light with quantum yields above 50%. This work is of great significance for further exploration of multifunctional molecular switch materials through halogen modification strategies.
Performance of multiparametric prostate magnetic resonance imaging validated by targeted and systematic transperineal biopsies
Authors: Hsi Richard A. , Dinh Tru‐Khang , Greer Matthew , Bensen Carleen , Mitchell Marc A. , Li Amy Y. , Stamm Andrew , Henne Manfred 
Published: August 2022

AbstractObjectiveTo measure the performance of multiparametric (mp) magnetic resonance imaging (MRI) to identify intraprostatic tumour deposits using a systematic and targeted MR‐guided transperineal prostate biopsy technique.Materials and MethodsPatients underwent a combined systematic and targeted MR‐guided transperineal biopsy procedure in the dorsal lithotomy position under general anaesthesia. Systematic biopsies were spaced 10 mm or less apart and additional biopsies targeted any Prostate Imaging–Reporting and Data System (PI‐RADS) 3, 4 or 5 lesions identified on mpMRI. Cancer detection rates were calculated on a per patient and per lesion basis.ResultsA total of 125 patients underwent the biopsy procedure. The positive predictive value (PPV) of mpMRI per patient was 59% for any cancer and 49% for Gleason score (GS) ≥ 7 cancer. The negative predictive value (NPV) of mpMRI per patient was 67% for any cancer and 88% for GS ≥ 7 cancer. On a per lesion basis, the PPV of PI‐RADS 3 lesions for any and GS ≥ 7 cancer was 24% and 10%. For PI‐RADS 4 lesions it was 42% and 32%. For PI‐RADS 5 lesions, it was 76% and 70%. MpMRI failed to identify GS ≥ 7 cancer found on systematic biopsy in 22% of patients.ConclusionBased on a combination of systematic and targeted transperineal prostate biopsies, mpMRI showed a high NPV and low PPV for GS ≥ 7 cancer on a per patient basis. The PPV of mpMRI on a per lesion basis increased with increasing PI‐RADS score. However, there were a significant number of both false positive as well as false negative (mpMRI invisible) areas within the prostate that contained GS ≥ 7 cancer. Therefore, pathologic confirmation using both targeted and systematic mapping biopsy is necessary to accurately identify all intraprostatic tumour deposits.
Liquid chromatography–tandem mass spectrometry method for simultaneous quantification of neurotransmitters in rat brain tissue exposed to 4′‐fluoro‐α‐PHP
Authors: Viana Roberta Rodrigues , Pego Ana Miguel Fonseca , de Oliveira Tiago Franco , Dallegrave Eliane , Eller Sarah 
Published: August 2022

AbstractThe combination of different advanced analytical techniques makes it possible to determine the concentrations of neurotransmitters in various biological matrices, providing a complex and comprehensive study of the effects of psychoactive substances. The present study aimed to develop and validate a fast and simple analytical method for the determination of acetylcholine, serotonin, γ‐aminobutyric acid, glutamate, dopamine and metabolites in rats brain tissue by liquid chromatography coupled to tandem mass spectrometry. The brain was homogenized and aliquots of the sample, dopamine‐d4, and acetone were added to a tube and then vortexed and centrifuged. The supernatant was collected and dried. The residue was reconstituted and injected. The LLOQ ranged from 0.001 to 1 μg/g; the intra‐run precision ranged from 0.47 to 11.52%; the inter‐run precision ranged from 0.68 to 17.54%; and the bias ranged from 89.10 to 109.60%. As proof of concept, the method was applied to animals exposed to the synthetic cathinone 4′‐fuoro‐α‐pyrrolidinohexanophenone (300 mg/kg). In addition, the workflow proved to be simple, rapid and useful to estimate the concentration of neurotransmitters. This analytical tool can be used to support the investigation of the changes in the neurochemical profile for the characterization of the mechanism of action of psychoactive substances, as well as both neurological and psychiatric diseases.