bluuebunny/crossref_metadata_2025_split huggingface dataset:
Publication tips: How to write scientific articles that master the publication process and communicate your ideas efficiently
Authors: Soares João B. P. 
Published: May 2022

AbstractThis article gives insights on how to write, submit, revise, and publish articles in scientific peer‐reviewed journals. I will focus on chemical engineering, but my suggestions apply to other natural sciences and engineering journals as well. I will start by discussing how to write the cover letter and the text of your article, emphasizing the importance of using clear language and highlighting the novelty of your results. I will then suggest how to prepare eye‐catching figures and tables that communicate your ideas effectively. Next, I will discuss the peer‐review process, explaining the roles of editors and reviewers, as well as how to revise your article and craft a rebuttal letter. I will also explain ethical misconduct in scientific publications.
Stress distribution and microgap formation in angulated zirconia abutments with a titanium base in narrow diameter implants: A 3D finite element analysis
Authors: Zhang Yuqiang , Yu Ping , Yu Haiyang 
Published: May 2022

AbstractThis in vitro study aimed to use failure stress and implant abutment interface (IAI) microgap size to find the compromised axial angle range of angulated zirconia abutments with a titanium base in narrow diameter implants in the esthetic region. A three‐dimensional (3D) finite element model of maxillary central incisor implant prosthesis was reconstructed. Angulated zirconia abutments (0°, 15°, 30°, and − 15°) with a titanium base in narrow diameter implants (3.3 × 12 mm, Bone level, Roxolid SLActive, Straumann AG, Switzerland) were designed to simulate clinical scenarios of buccal inclination 0°, 15°, and 30°, and palatal inclination 15° of the implant long axis. Straight titanium abutment and pure titanium implant were used as two control groups. An oblique force at 30° inclination to the long axis of the crown was applied 3 mm below the incisal edge on the palatal surface of the prosthesis. Under simulated dynamic chewing force, the stress distribution of the implant components and surrounding bone were investigated. The relative micromotion displacement between the implant and abutment models at the IAI area was recorded, and the influence of tightening torque on the IAI microgap was evaluated. The angulation of the zirconia abutment could affect the stress value and IAI microgap of implant restorations. When the zirconia abutment angle increased from −15° to 30°, the stress on the central screw, titanium base, and surrounding bone tissue gradually increased by 9%, 20%, and 23%, respectively. The stress levels of the 30° zirconia abutment group showed the risk of exceeding the threshold. When the long axis of the implant was inclined in the palatal direction, the −15° angle abutment reduced the stress by 3% and reduced the strain level of the implant system by 17% and the surrounding bone tissue by 26%. Under simulated dynamic chewing load, the displacement between the implants and the abutment occurred in each group of the implant system, and the amplitude of the micromotion fluctuated with the change in the load. The horizontal displacement caused a 0.075–1.459 μm palatal microgap and 0.091–0.945 μm distal microgap in the IAI. The microgap between the lip and palate was more evident, and the vertical displacement difference was manifested as the abutment sliding down the implant. In cases of upper implant restoration with difficulties such as small gaps and axial defects in the esthetic zone, the abutment angle is highly recommended to be in a slightly palatal‐inclined direction or to not exceed 15° when the implant is inclined to the labial side to avoid mechanical damage and leakage caused by the appearance of excessively large micromotion gaps.
Targeting And‐1 to overcome radiation resistance in colorectal cancer
Authors: Principe Daniel R. 
Published: May 2022

AbstractColorectal cancer (CRC) is a leading cause of cancer‐related death worldwide. Although overall outcomes have improved in recent decades, metastatic disease is associated with a particularly poor prognosis, underscoring a need to both identify new therapeutic modalities as well as actionable mechanisms of resistance to the current standard of care treatments. Radiation is an important part of treatment for many rectal cancer patients and is under extensive investigation in CRC. A recent study by Zhao and colleagues published in Clinical and Translational Medicine has identified novel insight into radiation resistance in CRC, as well as a potential means of enhancing therapeutic responses to radiation. The authors determined that O‐GlcNAcylation of the DNA repair protein And‐1 is an obligate step in And‐1‐mediated double‐strand break homologous recombination (HR). They also show that this phenomenon drives radiation resistance in vitro and can be overcome by repurposing the selective estrogen receptor modulator (SERM) bazedoxifene acetate as an And‐1/HR inhibitor.
Comparison of plasma and CSF biomarkers across ethnoracial groups in the ADNI
Authors: Windon Charles , Iaccarino Leonardo , Mundada Nidhi , Allen Isabel , Boxer Adam L. , Byrd Desiree , Rivera‐Mindt Monica , Rabinovici Gil D. ,   ADNI
Published: May 2022

AbstractIntroductionEthnoracial differences in cerebrospinal fluid (CSF; amyloid beta 42 [Aβ42], total tau [t‐tau], phosphorylated tau 181 [p‐tau181], and plasma (p‐tau181, neurofilament light [NfL]) biomarkers of Alzheimer's disease (AD) are incompletely understood.MethodsWe performed cross‐sectional analyses with and without adjustment for covariates comparing baseline CSF (Aβ42, t‐tau, p‐tau181) and plasma (p‐tau181, NfL) values in 47 African Americans (AAs) matched to 141 non‐Hispanic Whites (NHWs) and 43 Latinos (LAs) matched to 129 NHWs from the Alzheimer's Disease Neuroimaging Initiative (ADNI).ResultsUnadjusted comparisons revealed no significant differences in plasma or CSF biomarkers between AAs and NHWs. A trend toward a lower CSF t‐tau and p‐tau181 in LAs compared to NHWs was observed, without significant differences in plasma biomarkers. After adjusting for covariates, there were no significant differences in CSF or plasma biomarkers between AAs and NHWs or between LAs and NHWs.DiscussionPlasma and CSF AD biomarkers may perform similarly across diverse populations but future studies in large, diverse cohorts are needed.
Incidence and causes of severe maternal outcomes in Somaliland using the sub‐Saharan Africa maternal near‐miss criteria: A prospective cross‐sectional study in a national referral hospital
Authors: Egal Jama Ali , Kiruja Jonah , Litorp Helena , Osman Fatumo , Erlandsson Kerstin , Klingberg‐Allvin Marie 
Published: May 2022

AbstractObjectiveTo describe the incidence and causes of severe maternal outcomes and the unmet need for life‐saving obstetric interventions among women admitted for delivery in a referral hospital in Somaliland.MethodsA prospective cross‐sectional study was conducted from April 15, 2019 to March 31, 2020, with women admitted during pregnancy or childbirth or within 42 days after delivery. Data were collected using the World Health Organization (WHO) and sub‐Saharan Africa (SSA) maternal near‐miss (MNM) tools. Descriptive analysis was performed by computing frequencies, proportions, and ratios.ResultsThe MNM ratios were 56 (SSA criteria) and 13 (WHO criteria) per 1000 live births. The mortality index was highest among women with medical complications (63%), followed by obstetric hemorrhage (13%), pregnancy‐related infection (10%), and hypertensive disorders (7.9%) according to the SSA MNM criteria. Most women giving birth received prophylactic oxytocin for postpartum hemorrhage prevention (97%), and most laparotomies (60%) for ruptured uterus were conducted after 3 h.ConclusionThere is a need to improve the quality of maternal health services through implementation of evidence‐based obstetric interventions and continuous in‐service training for healthcare providers. Using the SSA MNM criteria could facilitate such preventive measures in this setting as well as similar low‐resource contexts.
Implementation of a standardized voiding protocol after minimally invasive surgery: A quality improvement initiative
Authors: Kim Soyoun Rachel , Laframboise Stéphane , Nelson Gregg , McCluskey Stuart A. , Avery Lisa , Kujbid Nastasia , Zia Aysha , Bernardini Marcus Q. , Ferguson Sarah E. , May Taymaa , Hogen Liat , Cybulska Paulina , Bouchard‐Fortier Geneviève 
Published: May 2022

AbstractObjectivesTo assess the effects of the implementation of a standardized voiding protocol in patients undergoing minimally invasive hysterectomy at a single cancer center in terms of the urinary tract infection (UTI) rate, time to first void, and overnight stays secondary to urinary retention.MethodsWe enrolled 102 consecutive patients undergoing minimally invasive hysterectomy at a single cancer center during a 12‐month period. A pre‐intervention cohort of 100 consecutive patients was identified for comparison. A multidisciplinary team developed and implemented a standardized voiding protocol using quality improvement methodology. We compared the demographics, time to first void, rate of urinary retention, and UTI rates between the pre‐ and post‐intervention cohorts.ResultsOur intervention led to a significant reduction in the time to first void (289 min vs. 566 min; P < 0.001), rate of urinary retention (2% vs. 10%; P = 0.015), and postoperative UTI (4% vs. 8%; P = 0.249). There was a similar rate of patients going home with a Foley catheter (9% vs. 11%; P = 0.850).ConclusionsImplementation of a standardized voiding protocol was associated with a reduction in rate of UTI, time to first void, and overnight stays secondary to urinary retention.
Loss of Parathyroid Hormone Receptor Signaling in Osteoprogenitors Is Associated With Accumulation of Multiple Hematopoietic Lineages in the Bone Marrow
Authors: Kimura Takaharu , Panaroni Cristina , Rankin Erinn B. , Purton Louise E. , Wu Joy Y. 
Published: May 2022

ABSTRACT
Osteoblasts and their progenitors play an important role in the support of hematopoiesis within the bone marrow (BM) microenvironment. We have previously reported that parathyroid hormone receptor (PTH1R) signaling in osteoprogenitors is required for normal B cell precursor differentiation, and for trafficking of maturing B cells out of the BM. Cells of the osteoblast lineage have been implicated in the regulation of several other hematopoietic cell populations, but the effects of PTH1R signaling in osteoprogenitors on other maturing hematopoietic populations have not been investigated. Here we report that numbers of maturing myeloid, T cell, and erythroid populations were increased in the BM of mice lacking PTH1R in Osx-expressing osteoprogenitors (PTH1R-OsxKO mice; knockout [KO]). This increase in maturing hematopoietic populations was not associated with an increase in progenitor populations or proliferation. The spleens of PTH1R-OsxKO mice were small with decreased numbers of all hematopoietic populations, suggesting that trafficking of mature hematopoietic populations between BM and spleen is impaired in the absence of PTH1R in osteoprogenitors. RNA sequencing (RNAseq) of osteoprogenitors and their descendants in bone and BM revealed increased expression of vascular cell adhesion protein 1 (VCAM-1) and C-X-C motif chemokine ligand 12 (CXCL12), factors that are involved in trafficking of several hematopoietic populations. © 2022 American Society for Bone and Mineral Research (ASBMR).
Diagnosis and discovery: Insights from the NIH Undiagnosed Diseases Program
Authors: Montano Carolina , Cassini Thomas , Ziegler Shira G. , Boehm Manfred , Nicoli Elena‐Raluca , Mindell Joseph A. , Soldatos Ariane G. , Manoli Irini , Wolfe Lynne , Macnamara Ellen F. , Malicdan May Christine V. , Adams David R. , Tifft Cynthia J. , Toro Camilo , Gahl William A. 
Published: May 2022

AbstractLiving with an undiagnosed medical condition places a tremendous burden on patients, their families, and their healthcare providers. The Undiagnosed Diseases Program (UDP) was established at the National Institutes of Health (NIH) in 2008 with the primary goals of providing a diagnosis for patients with mysterious conditions and advancing medical knowledge about rare and common diseases. The program reviews applications from referring clinicians for cases that are considered undiagnosed despite a thorough evaluation. Those that are accepted receive clinical evaluations involving deep phenotyping and genetic testing that includes exome and genomic sequencing. Selected candidate gene variants are evaluated by collaborators using functional assays. Since its inception, the UDP has received more than 4500 applications and has completed evaluations on nearly 1300 individuals. Here we present six cases that exemplify the discovery of novel disease mechanisms, the importance of deep phenotyping for rare diseases, and how genetic diagnoses have led to appropriate treatment. The creation of the Undiagnosed Diseases Network (UDN) in 2014 has substantially increased the number of patients evaluated and allowed for greater opportunities for data sharing. Expansion to the Undiagnosed Diseases Network International (UDNI) has the possibility to extend this reach even farther. Together, networks of undiagnosed diseases programs are powerful tools to advance our knowledge of pathophysiology, accelerate accurate diagnoses, and improve patient care for patients with rare conditions.
Relationship and prognostic significance of IL-33, PD-1/PD-L1, and tertiary lymphoid structures in cervical cancer
Authors: Zhang Ying , Li Jing , Yang Fan , Zhang Xiying , Ren Xiubao , Wei Feng 
Published: May 2022

AbstractIL-33, an epithelial-derived cytokine, functions as an alarmin for the immune system in the tumor microenvironment (TME). However, the expression and role of IL-33 on cervical cancer remain unclear. The aim of this study was to investigate the expression of IL-33 and its relationship with clinicopathologic features, tertiary lymphoid structures (TLS), and programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L1) immune checkpoints by immunohistochemistry in 93 cervical cancer patient specimens. Down-regulation of IL-33 expression was observed in tumor tissues compared with adjacent tissues. More importantly, IL-33 was detected in the cytoplasm of tumor fraction. IL-33 expression in tumor cytoplasm was associated with tumor size and the invasive depth of tumors (p &lt; 0.05). Meanwhile, IL-33 expression in tumor cytoplasm was positively correlated with infiltration of CD3+ T cells, CD8+ T cells, and PD-L1 expression in tumor tissues (p &lt; 0.05). The number of TLS strongly correlated with the depth of tumor invasion, preoperative chemotherapy, human papillomavirus infection, and high level of PD-1 (p &lt; 0.05). However, there was no significant relationship between IL-33 and TLS. Kaplan–Meier survival curves showed that the formation of TLS was associated with a better prognosis (p = 0.008). In multivariable Cox regression modeling, high expression of PD-L1 in tumor tissues was correlated with poor prognosis (HR = 0.128; 95% CI: 0.026–0.646; p = 0.013), whereas the high expression of IL-33 in tumor tissues was associated with better prognosis (HR = 5.097; 95% CI:1.050–24.755; p = 0.043). These results indicate that IL-33, TLS, and PD-L1 are potentially valuable prognostic predictor for cervical cancer. IL-33 has potential for combination with PD-L1-related antitumor therapy.
Radiation pressure on inhomogeneous active chiral structures with propagation matrix
Authors: He Simin , Wang Maoyi , Zhang Shitian , Li Guiping , Yu Mengxia , Liu Yu , Xu Jun , Wang Maoyan 
Published: May 2022

AbstractThe propagation matrix method and the Maxwell stress tensor are developed to calculate radiation pressure on an inhomogeneous active chiral structure. Based on boundary conditions, a 4 × 4 propagation matrix connecting two forward and two backward plane waves in adjacent chiral media is derived. This propagation matrix method allows us to access the net, co‐ and cross‐polarized radiation pressure, which are expressed by co‐ and cross‐polarized reflection and transmission coefficients, exerted on magnetoelectric coupling inhomogeneous chiral slabs via the derivation of the Maxwell stress tensor for arbitrary polarized plane waves incidence. The accuracies of the methods are examined using the finite difference time domain method and the Lorentz force densities. The radiation pressure on a homogeneous or inhomogeneous active chiral slab affected by the angle of incidence, thickness, chirality parameter, and polarization states of incident waves are investigated. This work is believed to provide insights for detecting chirality parameters of inhomogeneous materials by optical forces.
Conventional regression analysis and machine learning in prediction of anastomotic leakage and pulmonary complications after esophagogastric cancer surgery
Authors: van Kooten Robert T. , Bahadoer Renu R. , ter Buurkes de Vries Bouwdewijn , Wouters Michel W. J. M. , Tollenaar Rob A. E. M. , Hartgrink Henk H. , Putter Hein , Dikken Johan L. 
Published: May 2022

AbstractBackground and ObjectivesWith the current advanced data‐driven approach to health care, machine learning is gaining more interest. The current study investigates the added value of machine learning to linear regression in predicting anastomotic leakage and pulmonary complications after upper gastrointestinal cancer surgery.MethodsAll patients in the Dutch Upper Gastrointestinal Cancer Audit undergoing curatively intended esophageal or gastric cancer surgeries from 2011 to 2017 were included. Anastomotic leakage was defined as any clinically or radiologically proven anastomotic leakage. Pulmonary complications entailed: pneumonia, pleural effusion, respiratory failure, pneumothorax, and/or acute respiratory distress syndrome. Different machine learning models were tested. Nomograms were constructed using Least Absolute Shrinkage and Selection Operator.ResultsBetween 2011 and 2017, 4228 patients underwent surgical resection for esophageal cancer, of which 18% developed anastomotic leakage and 30% a pulmonary complication. Of the 2199 patients with surgical resection for gastric cancer, 7% developed anastomotic leakage and 15% a pulmonary complication. In all cases, linear regression had the highest predictive value with the area under the curves varying between 61.9 and 68.0, but the difference with machine learning models did not reach statistical significance.ConclusionMachine learning models can predict postoperative complications in upper gastrointestinal cancer surgery, but they do not outperform the current gold standard, linear regression
In‐situ grown metal organic framework synergistic system for the enantioseparation of three drugs in open tubular capillary electrochromatography
Authors: Wang Chen , Chen Cheng , Ma Mingxuan , Feng Zijie , Du Yingxiang 
Published: May 2022

Metal organic frameworks have received great attention as the chiral stationary phase for racemic drug separation because of their fascinating structures and properties. However, the most homochiral metal organic frameworks were constructed by rare and precious chiral organic ligands. In this work, an achiral metal organic framework, together with a natural chiral selector carboxymethyl β‐cyclodextrin built a synergistic separation system in the open tubular capillary electrochromatography. The novel coated columns were developed by inducing metal organic framework nanoparticles to grow on the imidazolyl functional capillary inner wall. The baseline separations of hydroxychloroquine, ofloxacin, and atenolol were achieved in the synergistic separation system. The effects of the concentration of chiral selector, pH, voltage, and the concentration of organic additives were studied. Compared with chiral selector auxiliary bare capillary, the resolutions of three drugs were remarkably improved. The relative standard deviations for the retention time of intraday (n = 6), interday (n = 6), and column‐to‐column were less than 2.1, 2.6, and 5.2%, respectively. These results demonstrate that affordable synergistic separation systems are prospective for racemic drug enantioseparation in capillary electrochromatography.
Lariciresinol Displays Anti‐Diabetic Activity through Inhibition of α‐Glucosidase and Activation and Enhancement of Insulin Signaling
Authors: Alam Md Badrul , Ra Jeong‐Sic , Lim Ji‐Young , Song Bo‐Rim , Javed Ahsan , Lee Sang‐Han 
Published: May 2022

ScopeThe aim of this study is to investigate the antidiabetic effect of lariciresinol (LSR) in C2C12 myotubes and streptozotocin (STZ)‐induced diabetic mice.Methods and resultsTo investigate antidiabetic potential of LSR, α‐glucosidase inhibitory assay, molecular docking, glucose uptake assay, western blot assay on antidiabetic biomarkers are performed. STZ‐induced diabetic model is used for in vivo study by calculating oral glucose tolerance test, histochemical examination, and glycogen assay. LSR inhibits α‐glucosidase activity with an IC50value of 6.97 ± 0.37 µM and acts as a competitive inhibitor with an inhibitory constant (Ki) value of 0.046 µM. In C2C12 cells, LSR activates insulin signaling leading to glucose transporter 4 (GLUT4) translocation and augmented glucose uptake. Furthermore, in Streptozotocin (STZ)‐treated diabetic mice, 3 weeks of oral LSR administration (10 mg kg−1) considerably decrease blood glucose levels, while increasing insulin levels in an oral glucose tolerance test, improve pancreatic islet size, increase GLUT4 expression, and significantly enhance insulin signaling in skeletal muscle. LSR treatment also activates glycogen synthase kinase 3β (GSK‐3β) resulting in improved glycogen content.ConclusionThe findings indicate a potential usefulness for oral LSR in the management and prevention of diabetes by enhancing glucose homeostasis.
Practical approach to clinical controversies in glycemic control for hospitalized surgical patients
Authors: Ware Lydia R. , Gilmore James F. , Szumita Paul M. 
Published: May 2022

AbstractThe importance of glycemic management in surgical patient populations stems from an association between hyperglycemia and increased rates of surgical site infections, sepsis, and mortality. Various guidelines provide recommendations regarding target glucose concentrations, but all stress the importance of avoiding hypoglycemia as well. Within the surgical patient population, glycemic targets may vary further depending on the surgical service, such as cardiac surgery, neurosurgery, or reconstructive burn surgery. Glycemic management in critically ill surgical patients is achieved primarily through the use of intravenous insulin infusion protocols. These protocols can include fixed protocols, multiplication factor protocols, and computerized algorithms. In contrast, noncritically ill surgical patients are generally managed through the utilization of subcutaneous insulin with a combination of basal, bolus, and sliding scale insulin. Insulin protocols should be effective at maintaining glucose concentrations within the specified target range with minimal hypoglycemic events. Monitoring glucose concentrations while on either an intravenous or subcutaneous insulin protocol is essential. Point‐of‐care testing is the primary method for monitoring glucose concentrations in both critically ill and noncritically ill surgical patients and allows for adjustment of the insulin regimen. As patients move between units and to the outpatient setting, ensuring adequate follow‐up is essential to maintaining control of hyperglycemia.