bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lightweight and flexible sensors based on environmental‐friendly poly(butylene adipate‐co‐terephthalate) composite foams with porous segregated conductive networks
Authors: Yang Jingbo , Ding Mingqi , Cai Wenrui , Xu Dawei , Park Chul B. 
Published: November 2022

AbstractConstructing the microcellular structure in the conductive polymer composites (CPCs) is a promising approach to improve the sensitivity and durability of the piezoresistive sensor. Selectively placing the conductive fillers, to form the segregated network between the polymer region, can effectively improve the electric performance of CPCs. However, few researches have focused on the influence of the polymer bead size on the segregated network and the large‐scale production of spherical polymer beads with low cost is still difficult to realize. Herein, plenty of regular‐shaped poly(butylene adipate‐co‐terephthalate) (PBAT) beads were manufactured through underwater pelletizing process, which was further coated with carbon nanotube (CNT) particles with the assistance of ball milling technology, and eventually the sensor was successfully fabricated through supercritical carbon dioxide (scCO2) bead foaming technology. The lightweight and flexible sensor exhibited the uniform cell structure with the mean cell size of 51.0 μm and cell density of 3.9 × 108 cells/cm3 when the pelletizing cutter speed was 2500 rpm and the foaming temperature was 117.5°C. And the conductivity of the sensor reached 6.5 S/m incorporated with 3 wt% CNT, which possessed high sensitivity, good stability and long‐term durability, attributed to its excellent microcellular structure and segregated conductive network.
Discovery of oxindole‐based FLT3 inhibitors as a promising therapeutic lead for acute myeloid leukemia carrying the oncogenic ITD mutation
Authors: Bender Onur , Shoman Mai E. , Ali Taha F. S. , Dogan Rumeysa , Celik Ismail , Mollica Adriano , Hamed Mohammed I. A. , Aly Omar M. , Alamri Abdulwahab , Alanazi Jowaher , Ahemad Nafees , Gan Siew Hua , Malik Jonaid Ahmad , Anwar Sirajudheen , Atalay Arzu , Beshr Eman A. M. 
Published: November 2022

AbstractFMS‐like tyrosine kinase 3 (FLT3) mutations occur in approximately 30% of acute myeloid leukemia (AML) patients. In the current study, the oxindole chemotype is employed as a structural motif for the design of new FLT3 inhibitors as potential hits for AML irradiation. Cell‐based screening was performed with 18 oxindole derivatives and 5a–c inhibited 68%–73% and 83%–91% of internal tandem duplication (ITD)‐mutated MV4‐11 cell growth for 48‐ and 72‐h treatments while only 0%–2% and 27%–39% in wild‐type THP‐1 cells. The most potent compound 5a inhibited MV4‐11 cells with IC50 of 4.3 µM at 72 h while it was 8.7 µM in THP‐1 cells, thus showing two‐fold selective inhibition against the oncogenic ITD mutation. The ability of 5a to modulate cell death was examined. High‐throughput protein profiling revealed low levels of the growth factors IGFBP‐2 and ‐4 with the blockage of various apoptotic inhibitors such as Survivin. p21 with cellular stress mechanisms was characterized by increased expression of HSP proteins along with TNF‐β. Mechanistically, compounds 5a and 5b inhibited FLT3 kinase with IC50 values of 2.49 and 1.45 µM, respectively. Theoretical docking studies supported the compounds' ability to bind to the FLT3 ATP binding site with the formation of highly stable complexes as evidenced by molecular dynamics simulations. The designed compounds also provide suitable drug candidates with no violation of drug likeability rules.
Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris
Authors: Raschig Martina , Ramírez‐Zavala Bernardo , Wiest Johannes , Saedtler Marco , Gutmann Marcus , Holzgrabe Ulrike , Morschhäuser Joachim , Meinel Lorenz 
Published: November 2022

AbstractIncreasing resistance against antimycotic drugs challenges anti‐infective therapies today and contributes to the mortality of infections by drug‐resistant Candida species and strains. Therefore, novel antifungal agents are needed. A promising approach in developing new drugs is using naturally occurring molecules as lead structures. In this work, 4,4'‐dihydroxyazobenzene, a compound structurally related to antifungal stilbene derivatives and present in Agaricus xanthodermus (yellow stainer), served as a starting point for the synthesis of five azobenzene derivatives. These compounds prevented the growth of both fluconazole‐susceptible and fluconazole‐resistant Candida albicans and Candida auris strains. Further in vivo studies are required to confirm the potential therapeutic value of these compounds.
Exploration of thiazolidine‐2,4‐diones as tyrosine kinase inhibitors: Design, synthesis, ADMET, docking, and antiproliferative evaluations
Authors: Aziz Nada A. A. M. , George Riham F. , El‐Adl Khaled , Mahmoud Walaa R. 
Published: November 2022

AbstractAs dual EGFR and VEGFR‐2 inhibitors, 22 innovative thiazolidine‐2,4‐diones were modeled, constructed, and measured for their anticancer performance versus four human neoplasms HCT‐116, MCF‐7, A549, and HepG2. Molecular docking and MD simulation were performed to inspect the binding technique of the proffered congeners with the EGFR and VEGFR‐2 receptors. Evidence realized thanks to the docking inquests was vastly consistent together with that detected through the biological screening. Structures 14a and 14g emerged as the most active compounds toward HCT116 (IC50 = 6.01 and 7.44 µM), MCF‐7 (IC50 = 5.77 and 7.23 µM), A549 (IC50 = 5.35 and 5.47 µM) and HepG2 (IC50 = 3.55 and 3.85 µM) tumefaction cells. Compounds 14a and 14g exhibited higher events than sorafenib (IC50 = 5.05, 5.58, 4.04, and 4.00 µM) against HepG2 instead subordinate incidents concerning A549, MCF‐7, and HCT116, parallelly. Nevertheless, these compounds signified weightier performance than erlotinib (IC50 = 13.91, 8.20, 5.49, 7.73, and µM), with respect to the four cell lines. Compounds having the best activity against the four cell lines, 12a–f, 13a–d, and 14a–g were chosen to appraise their in vitro VEGFR‐2 and EGFRT790M inhibiting activities. The best results were for compounds 14a and 14g compared to sorafenib and erlotinib, respectively, with IC50 values of 0.74 and 0.78 µM and 0.12 and 0.14 µM, respectively. Moreover, 13d, 14a, and 14g showed an adequate in silico calculated ADMET profile. The current investigation presents novel candidates for future optimization to construct mightier and eclectic binary VEGFR‐2/EGFRT790M restrainers with higher antitumor effects.
Eco‐friendly polyol through in situ hydroxylation from epoxidation of palm oleic acid via heterogeneous catalyst
Authors: Azmi Intan S. , Hadi Abdul , Jalil Mohd J. 
Published: November 2022

AbstractThe world's consumption of raw materials has shifted from the use of non‐renewable materials to renewable materials. Studies on greener epoxidation using vegetable oils to produce eco‐friendly polyol have also increased. This study aims to produce polyol‐based epoxidized palm oleic acid with a high hydroxyl value by a novel method which is continuous hydroxylation of epoxidized palm oleic acid using a heterogeneous catalyst. Starting from the raw palm oleic acid, the double bonds are functionalized by introducing epoxy groups and ring‐opened to produce hydroxyl groups. The best process parameters for epoxidation were optimized to maximize the oxirane value and to focus on oxirane stability. The relative conversion to the oxirane percentage was maximum (82%) after 30 min of epoxidation reaction. Fourier transform infrared spectroscopy showed an absorption peak at a wavelength of 3300 cm−1, indicating the presence of a hydroxyl group when polyol was analyzed. Overall, polyol with a high hydroxyl value (339 mg KOH/g), high yield (80.7%) and average molecular weight of 1045 Da was successfully produced from palm oleic acid using continuous hydroxylation of epoxidized oleic acid. Based on hydroxyl value and average molecular weight, the polyol is deemed suitable for producing rigid polyurethane foam. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.
Epigenetics across the evolutionary tree: New paradigms from non‐model animals
Authors: Sadler Kirsten C. 
Published: November 2022

AbstractAll animals have evolved solutions to manage their genomes, enabling the efficient organization of meters of DNA strands in the nucleus and allowing for nuanced regulation of gene expression while keeping transposable elements suppressed. Epigenetic modifications are central to accomplishing all these. Recent advances in sequencing technologies and the development of techniques that profile epigenetic marks and chromatin accessibility using reagents that can be used in any species has catapulted epigenomic studies in diverse animal species, shedding light on the multitude of epigenomic mechanisms utilized across the evolutionary tree. Now, comparative epigenomics is a rapidly growing field that is uncovering mechanistic aspects of epigenetic modifications and chromatin organization in non‐model invertebrates, ranging from octopus to sponges. This review puts recent discoveries in the epigenetics of non‐model invertebrates in historical context, and describes new insight into the patterning and functions of DNA methylation and other highly conserved epigenetic modifications.
Reclaiming “Mydentity”: Counterstorytelling to challenge injustice for racially and economically marginalized emerging adults
Authors: Pender Kristen N. , Hope Elan C. , Sondel Beth 
Published: November 2022

AbstractEmerging adulthood is an important period for identity development, the development of sociopolitical beliefs, and establishment of social roles and responsibilities. As a part of this development, counterstorytelling—narrative processes that contrast and challenge dominant oppressive narratives—may be used within counterspaces to facilitate positive identity development and to challenge injustice. In this qualitative study, we analyse interviews with and poetry from 12 emerging adults who were facilitators within a youth critical literacy program to understand how counterstorytelling functions to both facilitate identity development and challenge injustice. We found evidence of two superordinate themes: reclaiming identity, taking ownership of identity through counterstorytelling; and co‐creating a narrative community, collectively building community through counterstorytelling. Findings support counterstorytelling promotes emergent identity development and works as a strategy for challenging injustice and oppression for marginalized emerging adults. Implications for practitioners and future research are discussed.
Hematological and neurological expressed 1 (HN1) activates c‐Myc signaling by inhibiting ubiquitin‐mediated proteasomal degradation of c‐Myc in hepatocellular carcinoma
Authors: Feng Jutao , Liu Yanmin , Fang Tianling , Zhu Jinrong , Wang Guoying , Li Jun 
Published: November 2022

AbstractHepatocellular carcinoma (HCC) has a poor prognosis due to the usually advanced stage at diagnosis. Sustained activation of the MYC oncogene is implicated in the development of HCC; however, the molecular mechanisms of MYC deregulation in HCC are poorly understood. Here, real‐time PCR and western blotting were used to measure the expression of hematological and neurological expressed 1 (HN1) in HCC cells. Expression of HN1 and MYC in clinical specimens was analyzed using immunohistochemistry. The role of HN1 in HCC proliferation, migration, and invasion was explored in vitro and in vivo. MYC expression was measured using real‐time PCR and western blotting. MYC transcriptional activity was assessed using a luciferase reporter system. Expression of MYC target genes was quantified using real‐time PCR. Protein interaction between MYC and HN1 was assessed using co‐immunoprecipitation and western blotting. We identified HN1 as a novel regulatory factor of the glycogen synthase kinase (GSK) 3β–MYC axis. HN1 expression is elevated in liver tumor tissues and cells, and significantly correlates with poor survival in HCC patients. Upregulation of HN1 promotes, and silencing of HN1 represses, the proliferation and metastasis of liver cancer cells in vitro and in vivo. Moreover, our results demonstrate that HN1 sustains stabilization and persistent activity of MYC via interaction with GSK3β in HCC. Importantly, the tumor‐promoting effects of HN1 on HCC cells were attenuated by suppressing MYC. In conclusion, constitutive activation of MYC by HN1 promotes the progression of HCC; therefore, HN1 might be a novel therapeutic target for HCC.
Correlation of aortic valve annular plane assessment by on‐table three‐dimensional rotational angiography and preprocedural computed tomography
Authors: Tanner Richard , Murphy Sean , Malone Ciara , McGorrian Catherine , Sugrue Declan , Barton David , Byrne Roger , Blake Gavin , Margey Ronan , Casserly Ivan P. 
Published: November 2022

AbstractObjectivesTo assess the correlation between the aortic valve annular plane (AVAP) obtained by preprocedural computed tomography (CT) with on‐table three‐dimensional rotational angiography (3DRA), in patients undergoing transcatheter aortic valve replacement (TAVR).BackgroundAccurate assessment of the AVAP is critical during TAVR procedures to enable optimal positioning and minimize complications. Most commonly, preprocedural CT has been used to determine the AVAP. However, this can differ from the actual AVAP obtained during the TAVR procedure.MethodsConsecutive TAVR patients at a single center undergoing both preprocedural CT and 3DRA were included in the study. The AVAP assessment by CT was performed using 3mensio software (Pie Medical Imaging). 3DRA assessment was performed using DynaCT (Siemens).ResultsA total of 100 patients were included in the analysis. A difference of ≥5° and ≥10° in both the LAO/RAO and cranial/caudal components of the AVAP projection angle as assessed by CT and 3DRA was recorded in 39% and 10% of patients, respectively. The concordance correlation coefficient for the LAO/RAO and cranial/caudal implantation angles was 0.519 (95% CI: 0.377–0.661) and 0.558 (95% CI: 0.432–0.684), respectively.ConclusionCorrelation between preprocedural CT and on‐table 3DRA in the prediction of the actual AVAP at the time of TAVR implantation is moderate.
Management of a right coronary artery mycotic coronary aneurysm with percutaneous intervention with covered stents
Authors: Price Justin , Okyere Robert , Al‐Kindi Sadeer , Gupta Anjan 
Published: November 2022

AbstractCoronary artery aneurysmal dilation is a rare finding with poorly understood mechanism of action that is found in small population of patients undergoing coronary angiography. Mycotic coronary aneurysm is an even rarer cause of coronary aneurysmal dilatation that develops as a potentially fatal complication of bacteremia. We present a case of mycotic right coronary artery aneurysm in a nonsurgical candidate with complex medical comorbidities treated with percutaneous coronary intervention via covered stents.
Multimodality imaging results of TAP versus novel modified TAP stenting in coronary bifurcation: From bench testing to first‐in‐man investigation
Authors: Ng Jaryl Chen Koon , Ang Huiying , Zhong Liang , Hakim Diaa , Marmagkiolis Kostas , Foin Nicolas , Leesar Massoud A. 
Published: November 2022

AbstractObjectivesWe investigated the results of T and small protrusion (TAP) versus a novel modification of TAP (mTAP) stenting by multimodality imaging in bench testing and in patients with coronary bifurcation lesions (CBL).BackgroundTAP stenting is a suboptimal technique for bailout side branch (SB) stenting.MethodsIn a bench model, optical coherence tomography (OCT), microscopic examinations (ME), and computational fluid dynamics (CFD) were performed after TAP and mTAP stenting. In 20 patients with CBL, 80 intravascular ultrasound (IVUS) examinations were performed during mTAP stenting in which the SB stent was pulled‐back to indent the inflated main vessel (MV) balloon and deployed while deflating it. For TAP stenting, the tip of the SB stent was positioned in the MV and deployed.ResultsIn bench testing, OCT showed neocarina length (NL) was shorter and minimum stent area (MSA) was larger after mTAP versus TAP stenting (2.84 ± 0.70 vs. 4.80 ± 020 mm; 6.75 ± 1.50 vs. 4.5 ± 2.2 mm2; respectively; p < 0.05). By ME, NL was shorter and shear rate trended lower after mTAP versus TAP stenting. In patients, IVUS showed MSA was larger after versus before mTAP stenting (6.32 ± 0.58 vs. 5.21 ± 0.56 mm2; p < 0.01); NL was 1.43 ± 0.22 mm with SB ostium coverage. The Seattle Angina questionnaire (SAQ) score was higher at 6 months versus baseline (85 ± 4.0 vs. 48 ± 6.0, respectively; p < 0.001).ConclusionsThis multimodality imaging study showed, for the first time, mTAP stenting resulted in larger stent area and shorter neocarina than TAP stenting in bench testing. In patients with CBL, mTAP stenting led to larger stent area, short neocarina with complete SB ostium coverage, and improved the SAQ score at follow‐up.
A case of right inguinal necrotizing skin and soft‐tissue infection
Authors: Boulas Konstantinos A. , Nathanailidou Maria , Sitaridis Konstantinos , Filippidis Isaac , Tsiariglis Ioannis , Hatzigeorgiadis Anestis 
Published: November 2022

AbstractMesh infection is the most common complication after elective hernia repair with an increasing incidence with time.
Cardiac involvement of diffuse large B‐cell lymphoma presenting as various arrythmias
Authors: Ido Tadakiyo , Minamiguchi Hitoshi , Ichibori Yasuharu , Hayashi Takaharu , Makino Nobuhiko , Hirayama Atsushi , Higuchi Yoshiharu 
Published: November 2022

AbstractSymptomatic cardiac involvement of malignant lymphoma is rare. Silent invasion of malignant lymphoma makes it difficult to diagnose it in the early phase of clinical course. We describe a case with cardiac involvement of diffuse large B‐cell lymphoma presenting various types of arrythmias that were not diagnosed until autopsy.
Lipohypertrophy contributing to severe diabetic ketoacidosis in type 1 diabetes: An increasing problem in the context of the COVID‐19 pandemic?
Authors: Smith Emilia Imogen , Ciutac Andra , Smith Jamie C. 
Published: November 2022

AbstractA 57‐year‐old man with type 1 diabetes was admitted with diabetic ketoacidosis during the COVID‐19 pandemic. On examination, there was evidence of severe lipohypertrophy on his abdomen. Repeated injection of subcutaneous insulin into areas of lipohypertrophy was thought to have contributed to the development of ketoacidosis.
Hyperbaric oxygen therapy in stage III C Kienböck disease: Time is bone
Authors: Cracchiolo Andrea N. , Genco Fabio , Lo Bue Rosalia , Palmeri Marco , Tantillo Diego , Re Giuseppe , Bonanno Biagio , Finazzo Mario , Palma Daniela Maria 
Published: November 2022

AbstractKienböck disease, also known as lunatomalacia, is a rare condition which can lead to progressive wrist pain and abnormal carpal motion. We present the case of a 30‐year‐old patient with Down syndrome who came to our observation for treatment of stage III C Kienböck disease. In September 2019, the patient reported wrist pain with limitation in movements and initially underwent conservative treatment without benefit. In October 2020, pain symptoms and difficult movements with reduced strength worsened and surgical treatment was proposed, but the patient and his family declined. Thereby the patient underwent conservative treatment with hyperbaric oxygen therapy (HBOT) 60 sessions, 100% oxygen at 2.5 absolute atmospheres (ATA), oxygen total time 60 min, once daily, five times per week. After 6 months, a positive clinical and radiological evolution were observed, with an improvement in the patterns of pain, motion, and strength and an almost complete involution of the process of aseptic necrosis of the semilunar. To the best of our knowledge, this is the first report of stage III C Kienböck's disease in Down's syndrome patient treated with HBOT.
A 9.8 Mb deletion at 7q31.2q31.31 downstream of FOXP2 in an individual with speech and language impairment suggests a possible positional effect
Authors: Iwata‐Otsubo Aiko , Klee Victoria H. , Ahmad Aaliya A. , Walsh Laurence E. , Breman Amy M. 
Published: November 2022

AbstractHaploinsufficiency of FOXP2 causes FOXP2‐related speech and language disorder. We report a 9.8 Mb deletion downstream of FOXP2 in a girl with speech and language impairment, developmental delay, and other features. We propose involvement of FOXP2 in pathogenesis of these phenotypes, likely due to positional effects on the gene.
Omental infarction and anterior wall adhesion presenting as surgical abdomen in a pediatric patient
Authors: Omran Kareem , Al Tamr Wissam Jamal 
Published: November 2022

AbstractOmental infarction is a rare cause of acute abdomen that can present in both the pediatric and adult populations causing adhesions or abscesses. Presentation may mimic appendicitis; however, ultrasonography may not be sufficient. We discuss the importance of CT imaging for the pre‐surgical diagnosis to avoid serious port‐site injuries.
Local bullous reaction as a cutaneous reaction after mRNA‐boosted vaccination in a post‐COVID patient
Authors: Kultawanich Kwanhatai , Sampattavanich Nattaporn 
Published: November 2022

AbstractCoronavirus disease 2019 (COVID‐19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The spectrum of symptomatic infection ranges from mild to critical with multiple severe complications. Many vaccines have been developed to prevent COVID‐19 disease, including an mRNA vaccine. Different adverse effects were reported as delayed large local reactions, swelling, erythema, urticarial, and morbilliform rashes. Among these, bullous reactions from the vaccine are considered rare. Here, we described a local bullous reaction after an mRNA booster vaccination in a post‐COVID patient.
Development of multiple myeloma after 15 years of treatment for polycythemia vera and successful treatment using bortezomib: A case report
Authors: Kimura Hideo , Furukawa Miki , Mori Hirotaka , Shiga Yutaka , Asai Jun , Satoh Keiji , Kai Tatsuyuki 
Published: November 2022

AbstractMultiple myeloma (MM) and polycythemia vera (PV) rarely coexist; the clinical manifestations and treatment of this coexistence have not been described. An 81‐year‐old woman developed MM 15 years after undergoing PV treatment and was successfully treated using bortezomib. Herein, we share our experience of treating MM under such unusual conditions.
Preparing school counselors for social justice group counseling: Examining, power, privilege, and intersectionality
Authors: Ieva Kara P. , Steen Sam , Beasley Jordon J. 
Published: November 2022

AbstractGiven the sociopolitical climate of schools today and multiple crises, school counselors are poised to center healing engagement, antiracist education, and social emotional learning through group counseling. Therefore, counselor education programs must prepare and train social justice‐engaged school counselors with advanced group knowledge and skills to fuel the success of all P‐12 schools. This manuscript specifically explores the extent to which school counselors use the lens of power, privilege, and intersectionality within the screening, planning, implementation, and evaluation of small groups. Results indicate while school counselors are facilitating small group counseling, contradictions exist in training and school counselors’ implementation of small groups from the lens of power, privilege, and intersectionality to promote social justice and antiracist practices in schools. School counselors perceive they were trained in small group counseling from the lens of power, privilege, and intersectionality, however, they reported that they do not implement group counseling from the same lens.