bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGUATAN KAPASITAS BADAN USAHA MILIK DESA MOIN FE'U MELALUI PELATIHAN LITERASI FINANSIAL DI DESA FATUKANUTU KECAMATA AMABI OEFETO K
Authors: Manubulu Herry Aprilia , Rosari Renya 
Published: February 2022

The existence of the Moin FE’U Bumdes has the aim of supporting the improvement of the welfare of the Fatukanutu village community and the Moin FE'U BUMDES can develop business units in utilizing the village's economic potential. Seeing the importance of the existence of BUMDES Moin Fe’U in an effort to improve the welfare of rural communities, the urgency of the need for service for BUMDES Moin FE'U is training to strengthen the capacity of village-owned enterprises through financial literacy training. Participants in this service are village officials and managers of BUMDES Moin Fe'U. The method of implementing the service is lecture, discussions and training. The stages implementation are 1) delivery of material about bussines plan and financial reports, 2) discussions, 3) the practice of preparing financial reports. The result of this PKM is for village officials and managers of Bumdes Moin Fe'U can make a bussines plan proposal and able to compile financial reports based on SAK ETAP.
Faktor yang Berhubungan dengan Pemanfaatan Antenatal Care (ANC) pada Masa Pandemi COVID-19 di Wilayah Kerja Puskesmas Tamamaung Kota Makassar
Authors: Firzia Alda , Muchlis Nurmiati , Amelia Andi Rizki 
Published: February 2022

Dalam situasi pandemi Covid-19 ini, banyak pembatasan hampir ke semua layanan rutin termasuk pelayanan Antenatal Care (ANC). Penelitian ini bertujuan untuk mengetahui faktor yang berhubungan dengan pemanfaatan Antenatal Care (ANC) pada masa pandemi Covid-19 di Wilayah Kerja Puskesmas Tamamaung Kota Makassar. Jenis penelitian ini menggunakan kuantitatif dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah ibu yang memiliki bayi 0-6 bulan di Wilayah Kerja Puskesmas Tamamaung Kota Makassar. Teknik pengambilan sampel yaitu menggunakan metode purposive sampling dengan jumlah sampel sebanyak 68 Responden. Metode analisis data menggunakan uji univariat dan bivariat dengan uji chi-square dan Fisher’s Exact Test. Dari hasil penelitian diperoleh bahwa ada hubungan bermakna antara akses dengan pemanfaatan Antenatal Care (ANC) yaitu (p value = 0.020 <0.05), ada hubungan bermakna antara sikap petugas kesehatan dengan pemanfaatan Antenatal Care (ANC) yaitu (p value = 0,010 <0,05), ada hubungan bermakna antara jarak kehamilan dengan pemanfaatan Antenatal Care (ANC) yaitu (p value = 0.021 <0.05), ada hubungan bermakna antara nilai sosial budaya dengan pemanfaatan Antenatal Care (ANC) yaitu (p value = 0.012 <0.05) di Wilayah Kerja Puskesmas Tamamaung Kota Makassar. Adapun saran peneliti terkait penelitian ini ialah kepada petugas kesehatan lebih memperbanyak penyuluhan dalam meningkatkan pengetahuan ibu khususnya mengenai resiko jarak kehamilan yang sangat dekat, meningkatkan kepercayaan masyarakat tentang pemanfaatan Antenatal Care (ANC) serta petugas kesehatan sebaiknya tidak hanya dikunjungi melainkan petugas kesehatan juga mengunjungi masyarakat yang masih merasa tempat pelayanan Antenatal Care (ANC) sulit dijangkau.
Analisis Spasial Konsentrasi Logam Berat Timbal (Pb) pada Ikan di Kanal Kota Makassar
Authors: Vidyastuti Nur Hijrah , Syam Nasruddin , Abbas Hasriwiani Habo 
Published: February 2022

Terkontaminasinya biota perairan seperti ikan oleh logam berat berupa timbal (Pb) dapat menyebabkan masalah terhadap kesehatan masyarakat yang mengonsumsi ikan yang terkontaminasi oleh logam berat. Adapun tujuan dari penelitian ini adalah untuk mengetahui konsentrasi logam berat timbal (Pb) pada ikan dan sedimen di Kanal Kota Makassar. Jenis penelitian ini adalah observasional dengan jenis rancangan exploratif dengan pendekatan analisis spasial Sistem Informasi Georafi (SIG) konsentrasi logam berat timbal (Pb) pada ikan di kanal Kota Makassar. Hasil penelitian ini menunjukkan bahwa konsentrasi timbal (Pb) pada ikan di titik I yaitu 0.093 µg/gr, pada titik II yaitu 0.035 µg/gr dan pada titik III yaitu 0.033 µg/gr. Titik I merupakan titik yang berpotensi lebih tinggi terkontaminasi logam berat timbal (Pb).
Práctica pedagógica en pro del pensamiento crítico y habilidades tecnológicas y digitales
Authors: Mesa Suarez Edgar Alcibiades 
Published: February 2022

Este artículo muestra las didácticas planteadas a los estudiantes de las asignaturas de contabilidad y banca y medios de pago, en el programa de Negocios Internacionales de la Fundación Universitaria del Área Andina. Su objetivo, plantear herramientas de análisis de problemas en la contabilidad aplicada y estructuración de un proyecto innovador en pro del pensamiento crítico, liderazgo colectivo y habilidades tecnológicas y digitales en los estudiantes.
Expone la matematización y cómo esta es relevante para el desempeño de los estudiantes en las asignaturas. Aclara el instrumento que se aplicó para validar los pre-saberes matemáticos. Especifica las didácticas planteadas. Argumenta la articulación con el modelo institucional y se resaltan los resultados obtenidos.
La práctica llevó al estudiante a validar sus competencias en el marco del evento académico shark investor, en el diseño, elaboración y aplicación de un modelo contable básico en Excel.
Prototipo ADEMO: práctica pedagógico-didáctica para administración de oxitocina, mediada por tecnología
Authors: Posada Morales María Neyfeth , Muñoz Astudillo María Nelcy 
Published: February 2022

La administración de oxitocina para inducir el parto, requiere, enfermeros con conocimientos y experticia en farmacología, matemáticas básica y fisiología del embarazo. Además de práctica simulada ya que los estudiantes no pueden actuar directamente sobre el paciente por cuestiones de seguridad. Razón por la cual hay que garantizarles el desarrollo de habilidades y destrezas desde la academia, y aunque la simulación clínica ha demostrado ser efectiva, ha tenido inconvenientes por la necesidad de espacios físicos y costos. Razones que llevaron al Grupo de Investigadores de Enfermería de Risaralda, a desarrollar un prototipo educativo ejecutable en la web, denominado “ADEMO”, que ha permitido a muchos estudiantes poner en práctica los conocimientos previos adquiridos sobre preparación y administración de oxitocina, sin límites de espacio y tiempo. Hoy 120 de ellos consideran que es un prototipo con diseño, contenido y navegabilidad adecuado para alcanzar ciertas competencias.
Introduction
Authors: Tuncel Yunus 
Published: February 2022

On behalf of myself and the editors for this debut edition, Yunus Tuncel and Francesca Ferrando, we are most pleased to offer the first issue of the Journal of the World Posthuman Society, 'Infinity: A Journal for Posthumanists'. The papers collected here were presented at the 24th World Congress of Philosophy held in Beijing in 2018. Paper are drawn from Roundtables and Workshops organized to accommodate the surging interest in Posthumanism. The reader may accept my assurance that within these pages is contained some of the most avant garde thinking in this bourgeoning movement in philosophy.
Pengembangan instrumen supervisi akademik dalam penerapan pembelajaran berdiferensiasi
Authors: Hariyati Nunuk , Karwanto Karwanto , Khamidi Amrozi , Rifqi Ainur 
Published: February 2022

Kebijakan Merdeka Belajar digulirkan Kementerian Pendidikan dan Kebudayaan sebagai wujud transformasi pengelolaan pendidikan yang menempatkan well-being peserta didik sebagai orientasi utama dalam kegiatan pembelajaran. Pembelajaran berdiferensiasi menjadi alternatif model pembelajaran yang mampu mewujudkan well-being bagi peserta didik. Sebagai seorang supervisor, Kepala Sekolah berperan penting dalam meningkatkan kualitas pembelajaran melalui kegiatan supervisi akademik. Pengembangan instrumen supervisi akademik yang mengarah pada pembelajaran berdiferensiasi menjadi salah satu upaya penting yang dapat mewujudkan well-being peserta didik sekaligus mendukung Kebijakan Merdeka Belajar. Analisis situasi di Kabupaten Nganjuk menghasilkan informasi: (1) pembelajaran berdiferensiasi belum diketahui secara detail oleh guru, (2) instrumen supervisi akademik dalam pembelajaran berdiferensiasi belum dikembangkan oleh kepala sekolah. Sehingga tujuan pengabdian kepada masyarakat ini adalah untuk meningkatkan pengetahuan dan mengembangkan instrumen supervisi dalam pembelajaran berdiferensiasi. Metode pelatihan yaitu melalui pendekatan ekspositori, pembimbingan, penugasan dan FGD (Focus Group Discussion) yang diikuti 54 Kepala Sekolah yang tergabung dalam MKKS. Hasil penelitian menunjukkan bahwa terjadi peningkatan rata-rata pro-test terhadap pre-test yaitu sebesar 20%. Selain itu penugasan terhadap kepala sekolah menjadi sangat efektif dalam meningkatkan keterampilan menyusun instrumen supervisi akademik dalam penerapan pembelajaran berdiferensiasi
Hip-Preserved Reconstruction Using a Customized Cementless Intercalary Endoprosthesis With an Intra-Neck Curved Stem in Patients With an Ultrashort Proximal Femur: Midterm Follow-Up Outcomes
Authors: You Qi , Lu Minxun , Min Li , Zhang Yuqi , Wang Jie , Wang Yitian , Zheng Chuanxi , Zhou Yong , Tu Chongqi 
Published: February 2022

Background: Hemiarthroplasty is widely used for proximal femoral reconstruction after tumor resection. However, complications of hemiarthroplasty include infection, hip dislocation, and acetabular wear. This study aimed to: (1) evaluate the reliability and validity of a customized cementless intercalary endoprosthesis (CCIE) with an intra-neck curved stem (INCS) to reconstruct femoral diaphyseal defects with an ultrashort proximal femur (UPF); (2) assess the lower extremity function after reconstruction with this endoprosthesis; and (3) identify the postoperative complications associated with the use of this endoprosthesis.Methods: Between October 2015 and May 2019, 13 patients underwent reconstruction with a CCIE with an INCS. The distance from the center of the femoral head to the midline of the body and the apex of the acetabulum was measured preoperatively. Additionally, the distance from the tip of the INCS to the midline of the body and the apex of the acetabulum was measured postoperatively. The femoral neck–shaft angle was also measured pre- and postoperatively. After an average follow-up duration of 46 months, the radiological outcomes of the CCIE with an INCS were analyzed. Function was evaluated with the Musculoskeletal Tumor Society (MSTS) score. Pain was measured using a paper visual analog scale (VAS) pre- and postoperatively, and complications were recorded.Results: Compared with our preoperative design, we found no significant difference in the postoperative distance from the tip of the INCS to the body midline (p = 0.187) and the apex of the acetabulum (p = 0.159), or in the postoperative femoral neck–shaft angle (p = 0.793). Thus, the INCS positions were deemed accurate. The average MSTS score was 26 (range: 24–28), and the VAS score was significantly decreased postoperatively compared with preoperatively (p &lt; 0.0001). No patients developed aseptic loosening, infection, periprosthetic fracture, or prosthetic fracture as of the last follow-up.Conclusion: The CCIE with an INCS was a valid and reliable method for reconstructing femoral diaphyseal defects with a UPF following malignant tumor resection. Postoperative lower extremity function was acceptable, with an appropriate individualized rehabilitation program, and the incidence of complications was low.
Changes in Physiological Tendon Substrate Stiffness Have Moderate Effects on Tendon-Derived Cell Growth and Immune Cell Activation
Authors: Konar Subhajit , Bolam Scott M. , Coleman Brendan , Dalbeth Nicola , McGlashan Sue R. , Leung Sophia , Cornish Jillian , Naot Dorit , Musson David S. 
Published: February 2022

Tendinopathy is characterised by pathological changes in tendon matrix composition, architecture, and stiffness, alterations in tendon resident cell characteristics, and fibrosis, with inflammation also emerging as an important factor in tendinopathy progression. The sequence of pathological changes in tendinopathy and the cellular effects of the deteriorating matrix are largely unknown. This study investigated the effects of substrate stiffness on tendon-derived cells (TDCs) and THP-1 macrophages using PDMS substrates representing physiological tendon stiffness (1.88 MPa), a stiff gel (3.17 MPa) and a soft gel (0.61 MPa). Human TDCs were cultured on the different gel substrates and on tissue culture plastic. Cell growth was determined by alamarBlue™ assay, cell morphology was analysed in f-actin labelled cells, and phenotypic markers were analysed by real-time PCR. We found that in comparison to TDCs growing on gels with physiological stiffness, cell growth increased on soft gels at 48 h (23%, p = 0.003). Cell morphology was similar on all three gels. SCX expression was slightly reduced on the soft gels (1.4-fold lower, p = 0.026) and COL1A1 expression increased on the stiff gels (2.2-fold, p = 0.041). Culturing THP-1 macrophages on soft gels induced increased expression of IL1B (2-fold, p = 0.018), and IL8 expression was inhibited on the stiffer gels (1.9-fold, p = 0.012). We also found that culturing TDCs on plastic increased cell growth, altered cell morphology, and inhibited the expression of SCX, SOX9, MMP3, and COL3. We conclude that TDCs and macrophages respond to changes in matrix stiffness. The magnitude of responses measured in TDCs were minor on the range of substrate stiffness tested by the gels. Changes in THP-1 macrophages suggested a more inflammatory phenotype on substrates with non-physiological stiffness. Although cell response to subtle variations in matrix stiffness was moderate, it is possible that these alterations may contribute to the onset and progression of tendinopathy.
Fabrication of In Situ Grown Hydroxyapatite Nanoparticles Modified Porous Polyetheretherketone Matrix Composites to Promote Osteointegration and Enhance Bone Repair
Authors: Wang Ningning , Qi Desheng , Liu Lu , Zhu Yanlin , Liu Hong , Zhu Song 
Published: February 2022

The repairment of critical-sized bone defects is a serious problem that stimulates the development of new biomaterials. In this study, nanohydroxyapatite (nHA)-doped porous polyetheretherketone (pPEEK) were successfully fabricated by the thermally induced phase separation method and hydrothermal treatment. Structural analysis was performed by X-ray diffraction. The water contact angles and scanning electron microscopy were measured to assess physical properties of surfaces. The mechanical strength of the composites is also determined. Microcomputed tomography is used to characterize the nHA content of the composites. The in vitro bioactivity of the composites with or without nHA was investigated by using murine pre-osteoblasts MC3T3-E1, and the results of cytotoxicity and cell proliferation assays revealed that the cytocompatibility of all specimens was good. Adherence assays were employed to examine the adhesion and morphology of cells on different materials. However, nHA-doped composites induced cell attachment and cell spreading more significantly. Osteogenic differentiation was investigated using alkaline phosphatase activity and alizarin red staining, and these in vitro results demonstrated that composites containing nHA particles enhanced osteoblast differentiation. Its effectiveness for promoting osteogenesis was also confirmed in an in vivo animal experiment using a tibial defective rat model. After 8 weeks of implantation, compared to the pure PEEK and pPEEK without nHA groups, the nHA-pPEEK group showed better osteogenic activity. The results indicate that the nHA-pPEEK composites are possibly a well-designed bone substitute for critical-sized bone defects by promoting bone regeneration and osteointegration successfully.
Enhanced Antimicrobial, Cytotoxicity, Larvicidal, and Repellence Activities of Brown Algae, Cystoseira crinita-Mediated Green Synthesis of Magnesium Oxide Nanoparticles
Authors: Fouda Amr , Eid Ahmed M. , Abdel-Rahman Mohamed Ali , EL-Belely Ehab F. , Awad Mohamed A. , Hassan Saad El-Din , AL-Faifi Zarraq E. , Hamza Mohammed F. 
Published: February 2022

Herein, the metabolites secreted by brown algae,Cystoseira crinita, were used as biocatalyst for green synthesis of magnesium oxide nanoparticles (MgO-NPs). The fabricated MgO-NPs were characterized using UV-vis spectroscopy, Fourier transforms infrared spectroscopy (FT-IR), Transmission Electron Microscopy (TEM), Scanning Electron Microscopy linked with energy-dispersive X-ray (SEM-EDX), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). Data showed successful formation of crystallographic and spherical MgO-NPs with sizes of 3–18 nm at a maximum surface plasmon resonance of 320 nm. Moreover, EDX analysis confirms the presence of Mg and O in the sample with weight percentages of 54.1% and 20.6%, respectively. Phyco-fabricated MgO-NPs showed promising activities against Gram-positive bacteria, Gram-negative bacteria, andCandida albicanswith MIC values ranging between 12.5 and 50 μg mL−1. The IC50value of MgO-NPs against cancer cell lines (Caco-2) was 113.4 μg mL−1, whereas it was 141.2 μg mL−1for normal cell lines (Vero cell). Interestingly, the green synthesized MgO-NPs exhibited significant larvicidal and pupicidal activity againstMusca domestica.At 10 μg mL−1MgO-NPs, the highest mortality percentages were 99.0%, 95.0%, 92.2%, and 81.0% for I, II, III instars’ larvae, and pupa ofM. domestica, respectively, with LC50values (3.08, 3.49, and 4.46 μg mL−1), and LC90values (7.46, 8.89, and 10.43 μg mL−1), respectively. Also, MgO-NPs showed repellence activity for adults ofM. domesticaat 10 μg mL−1with 63.0%, 77.9%, 84.9%, and 96.8% after 12, 24, 48, and 72 h, respectively.
Method Improving for Isolation and Characterization of Allergy-Inducing Polymer Impurities in Cefotaxime Sodium Medicines Available From Pharmaceutical Industry
Authors: Fu Yanan , Li Jin , Feng Fang , Yin Lihui 
Published: February 2022

Objective: To prepare and validate the chemical structure of the cefotaxime dimer and cefotaxime trimer impurities available from pharmaceutical industry.Methods: A polymer stock solution of cefotaxime sodium was obtained using a concentrated solution degradation method. The cefotaxime dimer and trimer impurities were separated and purified by preparative reversed-high-performance liquid chromatograph (RP-HPLC), and the pure cefotaxime dimer and trimer were obtained by a freeze-drying method. The two impurities were characterized by infrared (IR) spectroscopy, ultraviolet (UV) spectroscopy, mass spectroscopy, and nuclear magnetic resonance (NMR, including one-dimensional and two-dimensional NMR). The groups corresponding to the characteristic absorption peaks in the UV and IR spectra were analyzed, and the 1H and 13C NMR signals were assigned.Results: The cefotaxime dimer was isolated and purified from the actual sample of industrial medicines, and chemical structure of the dimer is the same as in the dimers investigated earlier. The polymerization sites and stereoscopic configuration of trimer impurity was validated for the first time.Conclusion: This study is of great significance for the study of the structures and quality control of polymer impurities in cephalosporin drugs. Promoting the polymerization sites study and providing a technical basis for allergic study of polymer impurities.
Real-World Experience With a Large Bore Vascular Closure Device During TAVI Procedure: Features and Predictors of Access-Site Vascular Complications
Authors: Masiero Giulia , D'Angelo Livio , Fovino Luca Nai , Fabris Tommaso , Cardaioli Francesco , Rodinò Giulio , Benedetti Alice , Boiago Mauro , Continisio Saverio , Montonati Carolina , Sciarretta Tommaso , Zuccarelli Vittorio , Scotti Andrea , Lorenzoni Giulia , Pavei Andrea , Napodano Massimo , Fraccaro Chiara , Iliceto Sabino , Marchese Alfredo , Esposito Giovanni , Tarantini Giuseppe 
Published: February 2022

BackgroundsAmong vascular closure devices (VCDs), the novel collagen plug-based MANTA VCD is the first designed for large bore percutaneous access. We aimed to assess the features and predictors of access-site vascular complications in an unselected trans-femoral transcatheter aortic valve replacement (TF-TAVR) population.MethodsPatients undergoing large bore arteriotomy closure with 18F MANTA VCD following TF-TAVR at a large tertiary care center from September 2019 to January 2021 were prospectively analyzed. Primary Outcome was the MANTA VCD access-site-related complications according to Valve Academic Research Consortium-3 (VARC) definitions. Its incidence and predictors were evaluated.ResultsEighty-eight patients (median age 82 years, 48% male, 3.3 median Society of Thoracic Surgeons score) undergoing TF-TAVR were included, mostly (63%) treated with a self-expandable device and with outer diameter sizes varied from 18F to 24-F. MANTA VCD technical success rate was 98%, while 10 patients (11%) experienced MANTA VCD access-site vascular complications which included 8% of minor complications and only to 2% of major events resulting in VARC type ≥2 bleeding. Vessel occlusion/stenosis (60%), perforation (20%), and pseudoaneurysm/dissection/hematoma (20%) occurred, but all were managed without surgical treatment. Independent predictors of failure were age (p = 0.04), minimum common femoral artery diameter (CFA) (p &lt; 0.01), sheath-to-femoral-artery ratio (SFAR) (p &lt; 0.01), and a lower puncture height (p = 0.03). A CFA diameter &lt;7.1 mm with a SFAR threshold of 1.01 were associated with VCD failure.ConclusionsIn a more comers TF-TAVR population, MANTA VCD was associated with reassuring rates of technical success and major access-site vascular complications. Avoiding lower vessel size and less puncture site distance to CFA bifurcation might further improve outcomes.
Maturation Fetus Ascending Aorta Elastic Properties: Circumferential Strain and Longitudinal Strain by Velocity Vector Imaging
Authors: Zhong Xin , Luo Yuanchen , Zhou Dan , Liu Minghui , Zhou Jiawei , Xu Ran , Zeng Shi 
Published: February 2022

ObjectiveThis study aimed to assess the circumferential and longitudinal strain of the fetal ascending aortic (AA) wall and establish a gestational age-associated longitudinal reference for aortic wall strain during the second half of pregnancy.MethodsSingleton fetuses with gestational age (GA) at 20 + 0 to 24 + 6 weeks were prospectively collected from a low-risk population. Global circumferential strain (GCS) and mean longitudinal strain (MLS) of the ascending aorta were measured serially at 4-week intervals using the velocity vector imaging (VVI) technique. Fractional polynomials were conducted to obtain the best-fitting curves between GA and AA strains. GA-specific reference percentiles of GCS and MLS were established by multilevel modeling.ResultsA total of 223 fetuses with a total of 1,127 serial observations were enrolled. GCS presented a second-degree fractional polynomial smoothing regression along GA (R2 = 0.635, P &lt; 0.05). Fetal aortic GCS remained unchanged at ~27.29% (20.36–35.6%) before 31 weeks and increased significantly from 31.36% (26.38–37.12%) at 31 weeks to 43.29% (30.5–56.78%) at term. MLS presented a third-degree fractional polynomial smoothing regression along GA (R2 = 0.465, P &lt; 0.05). MLS remained steady at ~10.03% (3.28–17.62%) between 20 and 31 weeks and then increased significantly from 12.68% (7.42–20.1%) at 32 weeks to 17.5% (9.67–25.34%) at term. The GCS was significantly higher than the MLS in the ascending aorta wall (p &lt; 0.001).ConclusionThe fetal ascending aorta wall demonstrates obviously greater circumferential strain than longitudinal strain. Both strains remained steady before the late trimester and then gradually increased until delivery, suggesting progressive maturation of aortic elasticity mechanics.