bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital Learning & Media
Authors: Reinsel Soulen Rita , Maness Madison 
Published: November 2022

The University School (pseudonym) is a teacher training lab which provides real world learning experiences with research-based instruction for K-5 (ages 5-12) students. The two research questions were: In what ways does professional development centered on the NC Digital Learning Competencies for Educators influence teacher/staff/student knowledge of NCWiseOwl? In what ways does professional development centered on the NC Digital Learning Competencies for Educators influence essential digital literacy skills? The researcher conducted a survey in April 2021 of University School faculty and staff to define current levels of knowledge as a first step. Several themes immediately arose from the results of the focus group interviews which include intentional professional development, awareness of digital content offerings, adding to teacher toolkit, use of credible resources, self-reliance/weaning off support from non-classroom educators, and the after effects of COVID-19 pandemic/resistance to online learning.
PKM Kelompok Pembudidaya Belut Sawah di Desa Puuhopa, Kecamatan Puriala, Kabupaten Konawe, Provinsi Sulawesi Tenggara
Authors: Idris Muhammad , Baharuddin Amirullah , Pangerang Utama Kurnia 
Published: November 2022

Telah dilakukan kegiatan pengabdian Program Kemitraan Masyarakat pada UMKM Srikandi yang beralamat di Desa Puuhopa, Kecamatan Puriala, Kabupaten Konawe Selatan, Sulawesi Tenggara, sekitar 102 Km dari Kampus Hijau Bumi Tridharma, Universitas Halu Oleo, Kendari, Sulawesi Tenggara. UMKM ini memproduksi Kopi Belut yang sudah dikenal di Sulawesi Tenggara. UMKM ini mengalami masalah kontinuitas produksi terkait penggunaan bahan baku belut sawah hasil tangkapan yang tergantung musim. Solusi telah dilakukan dengan upaya budidaya belut sawah pada 48 kolam beton yang dikelola sendiri, namun kendalanya adalah pakan berupa keong mas, cacing tanah dan bekicot yang juga bersifat musiman, dan bahan lumpur untuk media belut sawah yang belum cukup. Kegiatan PKM mengintroduksikan dua jenis pakan belut sawah yang dibudidakan untuk menjamin kontinuitasnya yakni maggot Black Soldier Flies (BSF), dan cacing tanah Lumbricus rubellus. Kegiatan meliputi pelatihan mitra, penyediaan rumah BSF dan media budidaya cacing tanah, praktek budidaya BSF dan cacing tanah, penyerahan peralatan, serta pendampingan selama berlangsungnya kegiatan budidaya. Evaluasi keberhasilan kegiatan, menggunakan dua pendekatan yakni proses dan hasil. Dari aspek proses, mitra yang hadir saat pelatihan, termasuk Kepala Desa Puuhopa, menunjukkan antusiasme, keingintahuan yang besar dan respon yang sangat positif. Dari aspek hasil, setelah pemberian materi, 100% peserta pelatihan mengetahui beberapa aspek sederhana dari BSF dan budidayanya. Disimpulkan, kegiatan PKM yang menghasilkan sinergi antara kampus dan UMKM Srikandi, berdampak positif bagi kedua pihak, dan mampu menyelesaikan masalah yang ada pada UMKM Srikandi.
Küçük Devlet, Büyük Güç: Vatikan
Authors: ACAR Handan , KARTIN Cengiz 
Published: November 2022

Dünyanın en küçük ama en güçlü devletlerinden biri olan Vatikan aynı zamanda dünyanın en esrarengiz devletidir. Vatikan’da hiçbir devletin yapamayacağı bir sistem ve yönetim anlayışı yürürlüktedir. Bürokrasisi 1000 kişiyi geçmemesine rağmen 1,3 milyar ile dünyanın en kalabalık dinsel topluluğu olan Katolikleri yöneten bu devletin tarihi cinayet, skandal ve entrikalarla doludur. Dünyanın önde gelen birçok şirketinin hissedarı olan, sayısız gayrimenkullere ve paha biçilemez sanat eserlerine sahip olan bu devletin servetinin ne kadar olduğu hiçbir zaman açıklanmamıştır. Dünya siyasetinde önemli rol oynayan Vatikan’la ilişkilerimiz 19. yüzyılın ikinci yarısından itibaren resmi olarak başlamıştır.
Vatikan-Türkiye ilişkileri hakkındaki az sayıdaki akademik çalışmaya katkı sağlamak amacıyla kaleme alınan bu çalışmada genel hatları ile Vatikan’ın yapısı ve Osmanlı’dan günümüze Vatikan ile olan münasebetler ele alınacaktır.
Wilayah Segregasi Etnik di Kota Medan
Authors: Kunarsih Sri , Tampilen Tampilen 
Published: November 2022

The purpose of this study is to describe the area of ethnic segregation in the city of Medan. Ethnic segregation is a concentration area where ethnic groups live based on similar backgrounds. This paper uses descriptive qualitative research methods with a case study approach. Data collection through literature study methods, interviews, and participatory observations. In the city of Medan although many ethnicities mingle but in terms of the area of residence still tend to be compartmentalized in similar ethnic concentration areas. In the concept of a plural and plural city system such as Medan such ethnic living conditions are considered less conducive. It should be in the plural and plural urban layout of each ethnicity that exists mingled by not expressing the symbols and background of the ethnicity. Thus creating a truly plural and plural social system in a complex social system.
Perkembangan Pendidikan di Tarutung Masa Kolonial
Authors: Tampubolon Oktavia Nasrani , Rizkiya Ayu , Nasution Abdul Haris 
Published: November 2022

This study aims to see how the development of education in Tarutung during the Dutch Government. The method used is the Historical research method. The stages in the historical research method consist of four stages (heuristics, verification, interpretation, and historiography). The results of the study concluded that one of the backgrounds of the Dutch Government was to open educational institutions in Tarutung, one of which was so that the Batak people could accept the Dutch presence to control North Tapanuli. The development of education for the Batak people by the Dutch, only followed the renewal movement that had been carried out by the mission. The missionaries have managed to get close to the Batak people. Even the German mission managed to Christianize the Batak people, they helped the Dutch to take control of Tapanuli. In the late 19th to early 20thcenturies, several schools and hospitals were built in Tarutung by the Dutch government. The Batak people are getting to know the outside world more and more. The Batak people also know a lot of letters and know numbers. Many young men have received education, and some continue their education to Batavia.
Analisis Penggunaan dan Dampak Layanan Utang Online Ilegal oleh Masyarakat di Surakarta
Authors: Nurhaliza Amalia , Rahman Abdul , Purwanto Danang 
Published: November 2022

Globalization has provided an impact on the development of increasingly advanced technology, one of which is in the field of finance with the emergence of financial technology. There are four types of technology financial services, one of which is currently developing in Indonesia is online debt services. This study discusses the use and impact of illegal online debt services by the public. This research uses descriptive qualitative research methods with a case study approach. The data were collected by conducting interviews with six selected informants using side purposive techniques. The results showed that the reason for using online debt services to pay for children's schooling, business capital, meet daily living needs, and pay previous debts. The driving factors are easy terms, fast processes, no collateral, and difficulty obtaining debt in other formal financial institutions. The impact is mainly intimidative collection and misuse of personal data to collect debts accompanied by threats that interfere with the economic, social and psychological comfort of illegal online debt borrowers.
A Systematic Review of Task Complexity in Language Learning
Authors: Wang Yan 
Published: November 2022

Task complexity has attracted increasing attention from researchers since it plays a crucial role in language learning. Researchers have examined it using various perspectives and achieved different results in terms of language learning. Nevertheless, to have a clear and overall understanding of the significance of task complexity, some questions are raised: (1) What are the appropriate theoretical frameworks?; (2) What other factors are relevant to task complexity?; (3) How is language learning related to task complexity? This literature review aims to map the results and findings of task complexity in language learning to answer the above three questions. According to the PRISMA diagram 2020, 23 articles from SCOPUS between 2012 and 2020 were selected for analysis. Findings show that task complexity is one of the most important factors in different language tasks based on two hypotheses, i.e. Cognitive Hypothesis and Limited Attentional Capacity Hypothesis. In addition, factors such as aptitude and working memory usually are co-studied with task complexity. Finally, limitations and further questions are concluded.
ANALISA V SLIP PADA SUMUR BUNYU BSB DENGAN METODE MOORE
Authors: Haryono Sri Haryono , Cahyono M. Sigit , Widya Mandala Wirawan 
Published: November 2022

Tulisan ini menganalisis vslip di daerah Bunyu, Tarakan, Kalimantan Timur yang merupakan suatu daerah yang berada dalam cekungan hidrokarbon. Metode yang digunakan pada penelitian ini adalah pengambilan data secara primer, yaitu pengamatan langsung dan diambil pada saat pemboran dan tertera dalam log bore termasuk mud weight fluida. Pada penelitian ini, sumur yang di evaluasi adalah sumur BSB, Lapangan Bunyu dengan menggunakan metode Moore. Variable terikatnya metode ini adalah dengan menghitung slip velocity (Vs) dengan korelasi Moore, yaitu dengan melihat hasil kesesuaian perhitungan vslip dengan menggunkan bilangan Reynold. Hasil analisa dari penelitian ini adalah pada kedalaman 5864 ft sampai 8708 ft, nilai rata-rata vslip lebih kecil dari va, vc dan vcut, hal ini menunjukkan bahwa cutting terangkat dengan baik dari dasar sumur kepermukaan, sehingga menghindari hal-hal yang tak diinginkan seperti pipe sticking (pipa terjebit).
Kata kunci: Cutting, Rehology, Reynold, Korelasi Moore
Seroprevalence and risk factors of Toxoplasma gondii infection in captive giant panda (Ailuropoda melanoleuca)
Authors: Yue Chanjuan , Yang Wanjing , Fan Xueyang , Lan Jingchao , Huang Wenjun , Zhang Dongsheng , Li Yunli , Liao Lihui , Ayala James Edward , Wu Kongju , Liu Yiyan , Zheng Weichao , Li Lin , Zhang Hongwen , Su Xiaoyan , Yan Xia , Hou Rong , Liu Songrui 
Published: November 2022

IntroductionToxoplasma gondii, a globally zoonotic protozoan parasite, infects most warm-blooded animals including the giant panda, and poses a serious threat to the giant panda conservation. However, the seroprevalence and the risk factors for toxoplasmosis in giant pandas are unknown. Here we aimed to determine the seroprevalence of T. gondii in the captive population of giant pandas and analyze the factors associated with the increased risk of infection.MethodsA total of 203 serum samples were collected from 157 (95 females and 62 males) captive giant pandas from 2007 to 2022, antibodies against T. gondii were screened using commercial ELISA and MAT kits.ResultsThe results showed 56 (35.67%) giant pandas were seropositive, age and transfer history between institutions were identifified as risk factors for T. gondii infection. It is suggested that age-related seroprevalence was the main factor, and housing multiple species in the same environment may increase the chance of cross-infection of T. gondii.DiscussionThis study can provide research data for developing policies for the prevention and control of T. gondii and protecting the health of captive giant pandas and other wildlife.
Diversity of resistant determinants, virulence factors, and mobile genetic elements in Acinetobacter baumannii from India: A comprehensive in silico genome analysis
Authors: Kumkar Shital N. , Kamble Ekta E. , Chavan Nikeeta S. , Dhotre Dhiraj P. , Pardesi Karishma R. 
Published: November 2022

IntroductionThe frequency of infections associated with multidrug resistant A. baumannii has risen substantially in India. The use of next-generation sequencing (NGS) techniques combined with comparative genomics has great potential for tracking, monitoring, and ultimately controlling the spread of this troublesome pathogen. Here, we investigated the whole genome sequences of 47 A. baumannii from India.MethodsIn brief, A. baumannii genomes were analyzed for the presence of antibiotic resistance genes (ARGs), virulence factors genes (VFGs), and mobile genetic elements (MGEs) using various in silico tools. The AbaR-type resistance islands (AbaRIs) were detected by examining the genetic environment of the chromosomal comM gene. Multilocus sequence types were determined using the Pasteur scheme. The eBURST and whole genome SNPs-based phylogenetic analysis were performed to analyze genetic diversity between A. baumannii genomes.Results and discussionA larger number of A. baumannii isolates belonging to the ST2 genotype was observed. The SNPs-based phylogenetic analysis showed a diversity between compared genomes. The predicted resistome showed the presence of intrinsic and acquired ARGs. The presence of plasmids, insertion sequences, and resistance islands carrying putative ARGs conferring resistance to antibiotics, quaternary ammonium compounds, and heavy metals was predicted in 43 (91%) genomes. The presence of putative VFGs related to adherence, biofilm formation and iron uptake was observed in the study. Overall, the comprehensive genome analysis in this study provides an essential insight into the resistome, virulome and mobilome of A. baumannii isolates from India.
Vanadyl sulfate-enhanced oncolytic virus immunotherapy mediates the antitumor immune response by upregulating the secretion of pro-inflammatory cytokines and chemokines
Authors: Alluqmani Nouf , Jirovec Anna , Taha Zaid , Varette Oliver , Chen Andrew , Serrano Daniel , Maznyi Glib , Khan Sarwat , Forbes Nicole E. , Arulanandam Rozanne , Auer Rebecca C. , Diallo Jean-Simon 
Published: November 2022

Oncolytic viruses (OVs) are promising anticancer treatments that specifically replicate in and kill cancer cells and have profound immunostimulatory effects. We previously reported the potential of vanadium-based compounds such as vanadyl sulfate (VS) as immunostimulatory enhancers of OV immunotherapy. These compounds, in conjunction with RNA-based OVs such as oncolytic vesicular stomatitis virus (VSVΔ51), improve viral spread and oncolysis, leading to long-term antitumor immunity and prolonged survival in resistant tumor models. This effect is associated with a virus-induced antiviral type I IFN response shifting towards a type II IFN response in the presence of vanadium. Here, we investigated the systemic impact of VS+VSVΔ51 combination therapy to understand the immunological mechanism of action leading to improved antitumor responses. VS+VSVΔ51 combination therapy significantly increased the levels of IFN-γ and IL-6, and improved tumor antigen-specific T-cell responses. Supported by immunological profiling and as a proof of concept for the design of more effective therapeutic regimens, we found that local delivery of IL-12 using VSVΔ51 in combination with VS further improved therapeutic outcomes in a syngeneic CT26WT colon cancer model.
Capsule endoscopy in Crohn's disease surveillance: A monocentric, retrospective analysis in Italy
Authors: Calabrese Carlo , Gelli Dania , Rizzello Fernando , Gionchetti Paolo , Torrejon Torres Rafael , Saunders Rhodri , Davis Jason 
Published: November 2022

BackgroundCrohn's disease (CD) is a potentially debilitating condition that burdens Italian healthcare substantially. The symptomatic management relies on prompt therapy adjustment to reduce flares and follow-up diagnostic inputs to maximise remission. Capsule endoscopy (CE) has introduced advantages in CD diagnostics, allowing the direct inspection of the entire gastrointestinal mucosa. The diagnostic procedure is comparable in effort to standard ileocolonoscopy (IC) but requires no anaesthesia. Whether CE follow-up improves clinical outcomes remains to be defined.ObjectivesTo provide a preliminary evaluation of CE in terms of clinical outcomes with respect to the standard of care ileocolonoscopy/MRE in Italy.MethodsThis retrospective analysis utilises anonymised, monocentric data from the S. Orsola-Malpighi Hospital IBD database in Bologna, Italy, collected between 1999 and 2019. Out of 421 adult patient records, 100 were included in the analysis (50 per arm, matched per demographic and clinical characteristics). The CE represented the intervention arm, whereas ileocolonoscopy/magnetic resonance enterography was the standard of care. The use of biologics, symptomatology course, and surgery were the outcomes.ResultsThe two techniques performed similarly overall. In general, no significant difference emerged in the use of biologics. The use of biologics appears reduced in the CE group, only in L4 patients after the first follow-up year. Similarly, surgery was seemingly less frequent among L4 patients in the CE group. No difference was found between groups in flare occurrence and duration. CE patients might have experienced longer and earlier first remissions, but no long-term difference persisted.ConclusionsThe CE group showed an apparent reduction in biologics and surgery, limiting to L4 diagnoses. More extensive, prospective, multicentre, randomised studies must corroborate these preliminary findings.
Seroprevalence of human brucellosis among the tribal and non-tribal population residing in an eastern state of India: Findings from the state-wide serosurvey
Authors: Parai Debaprasad , Sahoo Subrat Kumar , Pattnaik Matrujyoti , Swain Aparajita , Peter Annalisha , Samanta Lopamudra Jena , Pradhan Rashmita , Choudhary Hari Ram , Nahak Kanhu Charan , Pati Sanghamitra , Bhattacharya Debdutta 
Published: November 2022

BackgroundBrucellosis is a neglected zoonotic disease found predominantly in lower- and middle-income countries (LMICs), causing significant public health concern in India. The objective of this study was to assess the prevalence of human brucellosis in Odisha, India among community members involved in animal husbandry as a common practice.MethodThis cross-sectional study included 817 adult participants from 11 districts in Odisha. Four districts from the Northern division, four districts from the Central division, and three districts from the Southern division were selected for the study. Blood samples were collected during a COVID-19 serosurvey in Odisha conducted from 1st to 17th September 2021. Immunoglobulin-G (IgG) antibodies were measured against Brucella using a commercial ELISA kit. Point estimates at 95% confidence intervals (CIs) and adjusted odds ratio were calculated.ResultsThe overall prevalence of anti-Brucella IgG antibodies was calculated at 16.65% (95% CI: 14.19–19.42). The highest seropositivity was found in Sambalpur district (29.73%; 95% CI: 16.43–47.16) and the lowest was determined in Mayurbhanj district (4.44%; 95% CI: 0.99–15.60). Compared to males, females were more prone to contracting the disease (AOR: 1.13; 95% CI: 1.05–1.67). Participants from rural settings had higher prevalence of anti-Brucella IgG antibodies than urban dwellers (AOR: 4.53; 95% CI: 1.73–11.86).ConclusionThis study revealed that human brucellosis was associated with sociodemographic factors like gender, living settings, and household numbers. To prevent brucellosis, screening should be initiated, infected humans should be treated early, and the public should be educated about risk factors and preventive measures.
Time-dependent alterations in the rat nigrostriatal system after intrastriatal injection of fibrils formed by α–Syn and tau fragments
Authors: Yang Xiaoman , Wang Jialing , Zeng Weiqi , Zhang Xiaoqian , Yang Xiaomei , Xu Yu , Xu Yan , Cao Xuebing 
Published: November 2022

IntroductionAccurate demonstration of phosphorylated α-synuclein aggregation and propagation, progressive nigrostriatal degeneration and motor deficits will help further research on elucidating the mechanisms of Parkinson’s Disease. α-synucleinN103 and tauN368, cleaved by activated asparagine endopeptidase in Parkinson’s Disease, robustly interacted with each other and triggered endogenous α-synuclein accumulation in a strong manner. However, the detailed pathophysiological process caused by the complex remains to be established.MethodsIn this study, rats were unilaterally inoculated with 15 or 30 μg of this complex or vehicle (phosphate buffered saline, PBS). Over a 6-month period post injection, we then investigated the abundance of pSyn inclusions, nigrostriatal degeneration, and changes in axonal transport proteins to identify the various dynamic pathological changes caused by pSyn aggregates in the nigrostriatal system.ResultsAs expected, rats displayed a dose-dependent increase in the amount of α-synuclein inclusions, and progressive dopaminergic neurodegeneration was observed throughout the study, reaching 30% at 6 months post injection. Impairments in anterograde axonal transport, followed by retrograde transport, were observed prior to neuron death, which was first discovered in the PFFs model.DiscussionThe current results demonstrate the value of a novel rat model of Parkinson’s disease characterized by widespread, “seed”-initiated endogenous α-Syn pathology, impaired axonal transport, and a neurodegenerative cascade in the nigrostriatal system. Notably, the present study is the first to examine alterations in axonal transport proteins in a PFF model, providing an appropriate foundation for future research regarding the mechanisms leading to subsequent neurodegeneration. As this model recapitulates some essential features of Parkinson’s disease, it provides an important platform for further research on specific pathogenic mechanisms and pre-clinical evaluations of novel therapeutic strategies.