bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cryptocurrency: The Future of Plastic Surgery Payments?
Authors: Atamian Elisa K , Bastidas Nicholas 
Published: May 2022

Abstract
Cryptocurrencies are digital currencies that allow for peer-to-peer transactions, maintained by a decentralized, secure, and trust-based system. Similar to the patient-centered care approach, cryptocurrency empowers the individual to transact, without a third-party, in a safe, largely transparent, and fast way. Awareness of the current economic state and the ongoing growth of cryptocurrency can place plastic surgeons in a unique and opportune position to broaden payment acceptance methods and create a more effective business model. By first creating a digital wallet for storage, and then employing a payment processing tool, transacting with cryptocurrency becomes practical and convenient. This paper explores the advantages and limitations of cryptocurrency and provides a high-level breakdown of the basics of accepting and transacting with cryptocurrency within a successful plastic surgery practice.
Painless, Drainless Lipoabdominoplasty: A Retrospective Study of Pain Following Lipoabdominoplasty Utilizing Liposomal Bupivacaine and a Modified Enhanced Recovery After Surgery Protocol
Authors: Shauly Orr , Goel Pedram , Gould Daniel J 
Published: May 2022

Abstract

Background
There are many functional and aesthetic benefits to lipoabdominoplasty (combination of liposuction with abdominoplasty), including increase in core strength, reduction in urinary incontinence, and improvement in lower back pain. However, patients are still hesitant to undergo surgery due to the perceived fears of postsurgical drains, and postoperative pain.

Objectives
To propose a standardized multimodal pain protocol for patients undergoing lipoabdominoplasty procedures that aims to improve postoperative pain control.

Methods
A total of 80 patients operated on between July 2020 and December 2021 were evaluated in this study. Patients all underwent lipoabdominoplasty and were administered a standardized preoperative, intraoperative, and postoperative pain regimen. Pain scores were measured across all patients in the immediate postoperative period, and postoperative days (PODs) 1, 7, 28, and 90.

Results
Mean pain scores in the postanesthesia recovery unit were 0.46/10 (+/− 0.18). Subsequent reassessment in the postop recovery suite yielded mean pain scores of 0.34 (+/− 0.15). Mean pain scores on POD1 were 1.23 (+/− 0.15) and consistent through to POD7 at 1.24 (+/− 0.11) with patients taking an average of 6.65 total Percocet 5 mg (Endo Pharmaceuticals Inc., Malvern, PA) during the week. After POD7, 95% (76/80) of patients were only taking nonsteroidal anti-inflammatory drugs. A total of 75/80 patients (93.75%) reported zero pain at 4 to 6 weeks after surgery (mean pain score 0.10 +/− 0.08).

Conclusions
The multimodal analgesia protocol consisting of preoperative or immediate induction intravenous Tylenol (Johnson & Johnson, New Brunswick, NJ), precut local analgesia with Marcaine (Pfizer Inc., New York, NY) and lidocaine, and intraoperative use of liposomal bupivacaine can improve perioperative pain control in patients undergoing lipoabdominoplasty.

Level of Evidence: 4
COT: an efficient and accurate method for detecting marker genes among many subtypes
Authors: Lu Yingzhou , Wu Chiung-Ting , Parker Sarah J , Cheng Zuolin , Saylor Georgia , Van Eyk Jennifer E , Yu Guoqiang , Clarke Robert , Herrington David M , Wang Yue 
Published: May 2022

Abstract

Motivation
Ideally, a molecularly distinct subtype would be composed of molecular features that are expressed uniquely in the subtype of interest but in no others—so-called marker genes (MGs). MG plays a critical role in the characterization, classification or deconvolution of tissue or cell subtypes. We and others have recognized that the test statistics used by most methods do not exactly satisfy the MG definition and often identify inaccurate MG.

Results
We report an efficient and accurate data-driven method, formulated as a Cosine-based One-sample Test (COT) in scatter space, to detect MG among many subtypes using subtype expression profiles. Fundamentally different from existing approaches, the test statistic in COT precisely matches the mathematical definition of an ideal MG. We demonstrate the performance and utility of COT on both simulated and real gene expression and proteomics data. The open source Python/R tool will allow biologists to efficiently detect MG and perform a more comprehensive and unbiased molecular characterization of tissue or cell subtypes in many biomedical contexts. Nevertheless, COT complements not replaces existing methods.

Availability and implementation
The Python COT software with a detailed user’s manual and a vignette are freely available at https://github.com/MintaYLu/COT.

Supplementary information
Supplementary data are available at Bioinformatics Advances online.
Deep structure integrative representation of multi-omics data for cancer subtyping
Authors: Yang Bo , Yang Yan , Su Xueping 
Published: May 2022

AbstractMotivationCancer is a heterogeneous group of diseases. Cancer subtyping is a crucial and critical step to diagnosis, prognosis and treatment. Since high-throughput sequencing technologies provide an unprecedented opportunity to rapidly collect multi-omics data for the same individuals, an urgent need in current is how to effectively represent and integrate these multi-omics data to achieve clinically meaningful cancer subtyping.ResultsWe propose a novel deep learning model, called Deep Structure Integrative Representation (DSIR), for cancer subtypes dentification by integrating representation and clustering multi-omics data. DSIR simultaneously captures the global structures in sparse subspace and local structures in manifold subspace from multi-omics data and constructs a consensus similarity matrix by utilizing deep neural networks. Extensive tests are performed in 12 different cancers on three levels of omics data from The Cancer Genome Atlas. The results demonstrate that DSIR obtains more significant performances than the state-of-the-art integrative methods.Availability and implementationhttps://github.com/Polytech-bioinf/Deep-structure-integrative-representation.gitSupplementary informationSupplementary data are available at Bioinformatics online.
MAFFIN: metabolomics sample normalization using maximal density fold change with high-quality metabolic features and corrected signal intensities
Authors: Yu Huaxu , Huan Tao 
Published: May 2022

AbstractMotivationPost-acquisition sample normalization is a critical step in comparative metabolomics to remove the variation introduced by sample amount or concentration difference. Previously reported approaches are either specific to one sample type or built on strong assumptions on data structure, which are limited to certain levels. This encouraged us to develop MAFFIN, an accurate and robust post-acquisition sample normalization workflow that works universally for metabolomics data collected on mass spectrometry (MS) platforms.ResultsMAFFIN calculates normalization factors using maximal density fold change (MDFC) computed by a kernel density-based approach. Using both simulated data and 20 metabolomics datasets, we showcased that MDFC outperforms four commonly used normalization methods in terms of reducing the intragroup variation among samples. Two essential steps, overlooked in conventional methods, were also examined and incorporated into MAFFIN. (i) MAFFIN uses multiple orthogonal criteria to select high-quality features for normalization factor calculation, which minimizes the bias caused by abiotic features or metabolites with poor quantitative performance. (ii) MAFFIN corrects the MS signal intensities of high-quality features using serial quality control samples, which guarantees the accuracy of fold change calculations. MAFFIN was applied to a human saliva metabolomics study and led to better data separation in principal component analysis and more confirmed significantly altered metabolites.Availability and implementationThe MAFFIN algorithm was implemented in an R package named MAFFIN. Package installation, user instruction and demo data are available at https://github.com/HuanLab/MAFFIN. Other data in this work are available on request.Supplementary informationSupplementary data are available at Bioinformatics online.
Formalist, Specialist, Pragmatist or Idealist—Approaches to Boundary Spanning in Personal Social Services
Authors: Grell Pär 
Published: May 2022

AbstractThe social services generally operate in the very centre of welfare systems marked by organisational specialisation. However, a downside to high levels of specialisation is the risk of service fragmentation, which may particularly affect clients with complex needs. In this context, work over organisational boundaries—boundary spanning—is a crucial challenge for staff when performing their duties for the benefit of both organisation and clients. The aim of this article is to describe and analyse approaches to boundary spanning in the daily work of Swedish personal social services staff, paying particular attention to the often overlooked informal dimensions of work. Findings from a non-participation observation study and a group interview study are presented. Four approaches to boundary spanning are identified and conceptualised: the ‘formalist’, ‘specialist’, ‘pragmatist’ and ‘idealist’ approaches. The article concludes with a discussion of influence of these approaches—and particularly dimensions of informal organisation—on future challenges for a specialised welfare sector.
Serum Neutralizing Antibody Titers 12 Months After Coronavirus Disease 2019 Messenger RNA Vaccination: Correlation to Clinical Variables in an Adult, US Population
Authors: Zhao Min , Slotkin Rebecca , Sheth Amar H , Pischel Lauren , Kyriakides Tassos C , Emu Brinda , McNamara Cynthia , Shi Qiaosu , Delgobbo Jaden , Xu Jin , Marhoffer Elizabeth , Mercer-Falkoff Aleagia , Holleck Jürgen , Ardito David , Sutton Richard E , Gupta Shaili 
Published: May 2022

Abstract

Background
We studied whether comorbid conditions affect strength and duration of immune responses after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA vaccination in a US-based, adult population.

Methods
Sera (before and after BNT162b2 vaccination) were tested serially up to 12 months after 2 doses of vaccine for SARS-CoV-2-anti-Spike neutralizing capacity by pseudotyping assay in 124 individuals; neutralizing titers were correlated to clinical variables with multivariate regression. Postbooster (third dose) effect was measured at 1 and 3 months in 72 and 88 subjects, respectively.

Results
After completion of primary vaccine series, neutralizing antibody half maximal inhibitory concentration (IC50) values were high at 1 month (14-fold increase from prevaccination), declined at 6 months (3.3-fold increase), and increased at 1 month postbooster (41.5-fold increase). Three months postbooster, IC50 decreased in coronavirus disease (COVID)-naïve individuals (18-fold increase) and increased in prior COVID 2019 (COVID-19+) individuals (132-fold increase). Age &gt;65 years (β = −0.94, P = .001) and malignancy (β = −0.88, P = .002) reduced strength of response at 1 month. Both neutralization strength and durability at 6 months, respectively, were negatively affected by end-stage renal disease ([β = −1.10, P = .004]; [β = −0.66, P = .014]), diabetes mellitus ([β = −0.57, P = .032]; [β = −0.44, P = .028]), and systemic steroid use ([β = −0.066, P = .032]; [β = −0.55, P = .037]). Postbooster IC50 was robust against WA-1 and B.1.617.2. Postbooster neutralization increased with prior COVID-19 (β = 2.9, P &lt; .0001), and malignancy reduced neutralization response (β = −0.68, P = .03), regardless of infection status.

Conclusions
Multiple clinical factors affect the strength and duration of neutralization response after primary series vaccination, but not the postbooster dose strength. Malignancy was associated with lower booster-dose response regardless of prior COVID infection, suggesting a need for clinically guided vaccine regimens.
Variable Effects of Temperature and Relative Humidity onRhipicephalus sanguineuss.l. (Acari: Ixodidae) Development
Authors: Tian Yuexun , Kaufman Phillip E , Taylor Caitlin E , Beati Lorenza , Lord Cynthia C 
Published: May 2022

AbstractRhipicephalus sanguineus s.l. (Latreille, 1806) can establish populations in residences and may lead to severe domestic and peridomestic infestations. Detection in the early infestation stage is challenging because of their small body size and the lack of visibility when ticks stay in sheltered refugia. The residents may believe that the infestation has been eliminated when no ticks are observed until ticks reappear when seeking hosts. Thus, it is necessary to improve our understanding of tick phenology to achieve more effective infestation management. In this study, the relationships between environmental conditions and tick development were explored in laboratory and using linear and nonlinear models. Three R. sanguineus s.l. strains, from one colony of the temperate lineage and two of the tropical lineage, were evaluated for the development of all life stages and conversion efficiency index (CEI) under five temperatures and four relative humidities (RHs). The development times differed between the three tick strains across stages and were primarily dependent on temperature. The CEIs had little variance explained by temperature, RH, or strains. Compared with the linear and exponential models with temperature as the only variable, the Brière-1 model was the best approximating model for most of the developmental rates. The developmental temperature thresholds for R. sanguineus s.l. development estimated by the Brière-1 model varied inconsistently across strains and life stages. We developed a more predictive relationship between environmental factors and R. sanguineus s.l. development, which can be utilized to predict tick development using temperature and develop appropriate control strategies.
Patch enlargement may not be a good strategy for treating tetralogy of Fallot with unbalanced pulmonary artery branches
Authors: Gao Botao , Zhu Zhongqun 
Published: May 2022

Abstract

OBJECTIVES
Our goal was to determine the optimal strategy for managing tetralogy of Fallot (TOF) with unbalanced pulmonary artery (PA) branches by investigating the different effects of PA plasty on the development of hypoplastic PA (HPA).

METHODS
A single-centre, retrospective analysis was carried out to compare the outcome of different PA plasty methods on the development of HPA in patients with TOF with unbalanced PA branches. Size and balance of the PA branches were used to evaluate the outcome of PA plasty.

RESULTS
In the NATIVE group, 100% of the HPAs were well-developed and all PA branches became balanced, whereas in the PATCH and EXTENSION groups, the percentage of well-developed HPAs was 40% and 33%, respectively, and none of the PA branches were balanced. In addition, HPAs became atretic in 28% of the patients in the patch enlargement group.

CONCLUSIONS
For TOF with unbalanced PA branches, patch enlargement may not be a good treatment strategy, because it reduces the growth potential of HPA and even causes iatrogenic atresia. Leaving the HPA in the native state without patch enlargement may be a good strategy.
Transseptal versus left atrial approach for mitral valve surgery: postoperative need for pacemaker
Authors: Ntinopoulos Vasileios , Haeussler Achim , Dushaj Stak , Papadopoulos Nestoras , Fleckenstein Philine , Dzemali Omer 
Published: May 2022

AbstractOBJECTIVESConcerns exist about higher rates of pacemaker implantation using the extended superior transseptal approach for mitral valve surgery. This study aims to compare the extended superior transseptal and the left atrial approach regarding the need for pacemaker implantation after mitral valve surgery.METHODSWe performed a retrospective analysis of the data of patients undergoing mitral valve surgery through either a sternotomy and transseptal approach or a mini-thoracotomy and left atrial approach in a single centre in the period January 2010 to May 2021. The primary outcome was the evaluation of the postoperative pacemaker implantation rate.RESULTSOverall, 677 patients were included, 333 with transseptal and 344 with left atrial approach, and 58 (8.6%) patients underwent pacemaker implantation postoperatively. There was no significant difference in the rate of pacemaker implantation between the 2 groups [overall: 34 (10.2%) vs 24 (7%), P = 0.133; for sinus node dysfunction: 12 (3.6%) vs 9 (2.6%), P = 0.459; for high-degree atrioventricular block: 22 (6.6%) vs 15 (4.4%), P = 0.199; transseptal vs left atrial approach, respectively]. A subgroup analysis of the relative effect of transseptal versus left atrial approach on the rate of postoperative pacemaker implantation revealed mitral replacement as a statistically significant confounder (P = 0.019). The exclusion of patients undergoing concomitant cardiac procedures did not lead to a statistically significant difference in the pacemaker implantation rate between the 2 approaches.CONCLUSIONSThe analysis of the data of these patients shows no significant difference in the rate of permanent pacemaker implantation between the extended superior transseptal and the left atrial approach for mitral valve surgery.
Developing a Harvest Plan by Considering the Effects of Skidding Techniques on Forest Soil Using a Hybrid TOPSIS-Entropy Method
Authors: Özer Genç Çiğdem , Arıcak Burak 
Published: May 2022

Abstract
The aim of this study was to evaluate skidding techniques, which result in minimal damage to the soil, depending on the slope and stand type. Thus, three skidding techniques with tractor for harvesting (suspended skidding [SS], using a skidding cone [SC], and cable-pulling [CP]) were used in six different study sites and the variations in soil properties were examined at three different slopes (0%–20%, 20%–33%, &gt;33%), 2 different stand types (A, B), and 2 different soil depths (0–5 cm, 5–10 cm). Soil bulk density, soil organic matter, soil compaction, organic carbon (C), and total nitrogen (N) were determined. The Entropy and TOPSIS methods were used among the multiple-criteria decision-making methods for six different coniferous stands.
With the combination of the Entropy and TOPSIS methods, we found that slope was an important factor in determining the preferred skidding technique. Suspended skidding was seen as the preferred method of skidding technique in the 0–20% slope group. For the 20%–33% slope group, the usability of the three methods varied depending on stand type and soil depth, whereas the technique using a skidding cone was found to be the preferred skidding technique in the &gt; 33% slope group.
Probiotic Lactobacillus brevis CLB3 prevents azoxymethane/dextran sulfate sodium-induced colon carcinogenesis in mice by reducing amino acid transport and IL-17A levels and repressing the IL-6/AKT/p-STAT3 signaling pathway
Authors: Qian Weiyi , Zhang Yong , Long Yan , Yang Wei , Hu Rui , Li Jinping , Leng Yan , Liu Xinjie , Li Qing X , Wan Xiangyuan , Wei Xun 
Published: May 2022

Abstract
Amino acid intake plays a crucial role in the Warburg effect of cancer. Gut microbes can regulate intestinal amino acid metabolism. However, it is still unknown whether probiotic therapy can protect the host from intestinal tumor invasion by reducing amino acid intake. With in vitro methods, three acid-tolerant strains from fermented pickles were screened out. Using azoxymethane/dextran sulfate sodium-induced colon cancer models, we evaluated the therapeutic effects of Lactobacillus brevis CLB3, Lactobacillus plantarum XLP, and Lactobacillus johnsonii CM on model mice. Their functional mechanisms were further explained through anatomy section, quantitative reverse transcrip­tion polymerase chain reaction (qRT-PCR), Western blot, and immunohistochemical staining analyses as well as database mining and gut culturomics. The Lactobacillus brevis (L. brevis) CLB3 treatment significantly improved the clinical signs and symptoms of colon cancer, alleviated colon damage, and inhibited colon carcinogenesis in mice. In addition, this treatment significantly increased gut cultivable Lactobacillus abundance, inhibited the expression and translation levels of the tumor metabolism-related solute carrier (SLC) amino acid transporter including SLC7A5 and SLC7A11, lowered circulating interleukin-6 (IL-6) and interleukin-17A (IL-17A) levels, and improved the accumulation of tumor-infiltrating lymphocytes and cancer proliferation factors. These findings suggest that L. brevis CLB3 can reduce amino acid transport, inhibit mammalian target of rapamycin (mTOR) signaling and enhance intestinal anti-tumor immune responses, which provides a potential targeting amino acid transporter strategy for preventing colorectal cancer.
The Link Between Childhood Adversity and Cardiovascular Disease Risk: Role of Cerebral and Systemic Vasculature
Authors: Rodriguez-Miguelez Paula , Looney Jacob , Blackburn Marsha , Thomas Jeffrey , Pollock Jennifer S , Harris Ryan A 
Published: May 2022

AbstractAdverse childhood experiences (ACEs) are traumatic events during the first years of life that are associated with a higher risk of developing cardiovascular disease (CVD) during adulthood. The medial prefrontal cortex (mPFC) is a core region in the brain that modulates emotions and is directly involved in the cardiovascular response to stress by increasing vascular resistance. In the present study we examined the relationship between ACEs, mPFC and peripheral vascular function. Forty-five, adults (33±5 yrs.) participated in the present study to evaluate cerebral hemodynamics and peripheral vascular function. The impact of adverse experiences was evaluated through the ACE questionnaire. Among those that experienced ACEs (ACE group, n = 22), there was a significantly (P &lt; 0.001) reduced activation of the mPFC as well as greater peripheral vascular resistance observed in the small (P ≤ 0.035), conduit (P ≤ 0.042) and large (P ≤ 0.001) blood vessels, when compared to those that did not report ACEs (Control group, n = 23). In addition, relationships between the number of ACEs and mPFC activation (rs = −0.428; P = 0.003) and peripheral vascular function (rs≤ −0.373; P ≤ 0.009) were observed. Findings from the present study support that adults who experienced ACEs exhibit a reduced activation of the mPFC along with systemic vascular dysfunction. In addition, individuals exposed to more childhood traumatic events exhibited a progressively greater inactivation of the mPFC and an increased peripheral vasoconstriction in a dose-dependent manner. These findings provide novel insights into the potential role that the brain and the peripheral vasculature may have in connecting adverse childhood events to the increased risk of CVD.
Genomic signatures of the evolution of a diurnal lifestyle in Strigiformes
Authors: Espíndola-Hernández Pamela , Mueller Jakob C , Kempenaers Bart 
Published: May 2022

AbstractUnderstanding the targets of selection associated with changes in behavioral traits represents an important challenge of current evolutionary research. Owls (Strigiformes) are a diverse group of birds, most of which are considered nocturnal raptors. However, a few owl species independently adopted a diurnal lifestyle in their recent evolutionary history. We searched for signals of accelerated rates of evolution associated with a diurnal lifestyle using a genome-wide comparative approach. We estimated substitution rates in coding and noncoding conserved regions of the genome of seven owl species, including three diurnal species. Substitution rates of the noncoding elements were more accelerated than those of protein-coding genes. We identified new, owl-specific conserved noncoding elements as candidates of parallel evolution during the emergence of diurnality in owls. Our results shed light on the molecular basis of adaptation to a new niche and highlight the importance of regulatory elements for evolutionary changes in behavior. These elements were often involved in the neuronal development of the brain.