bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human umbilical cord mesenchymal stem cell-derived treatment of severe pulmonary arterial hypertension
Authors: Hansmann Georg , Chouvarine Philippe , Diekmann Franziska , Giera Martin , Ralser Markus , Mülleder Michael , von Kaisenberg Constantin , Bertram Harald , Legchenko Ekaterina , Hass Ralf 
Published: June 2022

AbstractHere we report application of human umbilical cord mesenchymal stem cell (HUCMSC)-derived therapy for pulmonary arterial hypertension (PAH). A 3-year-old female presented with heritable PAH associated with hereditary hemorrhagic telangiectasia and was treated for 6 months with serial intravascular infusions of conditioned media (CM) from allogenic HUCMSCs. The treatment markedly improved clinical and hemodynamic parameters and decreased blood plasma markers of vascular fibrosis, injury and inflammation. A comparative analysis of single-cell RNA sequencing data collected from three HUCMSCs and two human umbilical vein endothelial cell (HUVEC) controls identified eight common cell clusters, all of which indicated regenerative potential specific for HUCMSCs. The properties of HUCMSCs were validated by untargeted label-free quantitation of the cell and CM proteome, suggesting increased activity of regeneration, autophagy and anti-inflammation pathways and mitochondrial function. Prostaglandin analysis demonstrated increased HUCMSC secretion of prostaglandin E2, known for its regenerative capacity. Additional prospective clinical studies are warranted to confirm and further explore the benefits of HUCMSC-derived therapy for PAH.
Cascade nanozymes based on the “butterfly effect” for enhanced starvation therapy through the regulation of autophagy
Authors: Yao Hanchun , Gong Xiaobao , Geng Meilin , Duan Songchao , Qiao Pan , Sun Fangfang , Zhu Zhihui , Du Bin 
Published: June 2022

The mechanism of Cur@MOF-GOx/HA nanozymes for enhanced starvation therapy via the autophagy regulation strategy.
The morphology of CS Cha circumbinary disk suggesting the existence of a Saturn-mass planet
Authors: Kurtovic N. T. , Pinilla P. , Penzlin Anna B. T. , Benisty M. , Pérez L. , Ginski C. , Isella A. , Kley W. , Menard F. , Pérez S. , Bayo A. 
Published: June 2022

Context. Planets have been detected in circumbinary orbits in several different systems, despite the additional challenges faced during their formation in such an environment.
Aims. We investigate the possibility of planetary formation in the spectroscopic binary CS Cha by analyzing its circumbinary disk.
Methods. The system was studied with high angular resolution ALMA observations at 0.87 mm. Visibilities modeling and Keplerian fitting are used to constrain the physical properties of CS Cha, and the observations were compared to hydrodynamic simulations.
Results. Our observations are able to resolve the disk cavity in the dust continuum emission and the 12CO J:3–2 transition. We find the dust continuum disk to be azimuthally axisymmetric (less than 9% of intensity variation along the ring) and of low eccentricity (of 0.039 at the peak brightness of the ring).
Conclusions. Under certain conditions, low eccentricities can be achieved in simulated disks without the need of a planet, however, the combination of low eccentricity and axisymmetry is consistent with the presence of a Saturn-like planet orbiting near the edge of the cavity.
Cost-effective analysis of preliminary single-operator cholangioscopy for management of difficult biliary stones
Authors: Sljivic Igor , Trasolini Roberto , Donnellan Fergal 
Published: June 2022

Abstract
Background and study aims Single-operator peroral cholangioscopy (SOC) is a therapeutic modality for difficult biliary stone disease. Given its high success rate and increasing availability, analysis of the economic impact of early SOC utilization is critical for clinical decision-making. Our aim is to compare the cost-effectiveness of different first and second-line endoscopic modalities for difficult-to-treat choledocholithiasis.
Patients and methods A decision-tree model with a 1-year time horizon and a hypothetical cohort of 200 patients was used to analyze the cost-effectiveness of SOC for first, second and third-line intervention in presumed difficult biliary stones. We adopted the perspective of a Canadian tertiary hospital, omitting recurrence rates associated with endoscopic retrograde cholangiopancreatography (ERCP). Effectiveness estimates were obtained from updated meta-analyses. One-way sensitivity analyses and probabilistic sensitivity analyses were also performed to assess how changes in key parameters affected model conclusions.
Results First- and second-line SOC achieved comparable clinical efficacy from 96.3 % to 97.6% stone clearance. The least expensive strategy is third-line SOC (SOC-3: $800,936). Performing SOC during the second ERCP was marginally more expensive (SOC-2: $ 816,584) but 9 % more effective. The strategy of first-line SOC incurred the highest hospital expenditures (SOC-1: $ 851,457) but decreased total procedures performed by 16.9 % when compared with SOC-2. Sensitivity analysis was robust in showing SOC-2 as the most optimal approach.
Conclusions Second-line SOC was superior to first and third-line SOC for treatment of difficult biliary stones. When based on meta-analysis of non-heterogeneous trials, SOC-2 is more cost-effective and cost-efficient. Our study warrants a larger pragmatic effectiveness trial.
Benefit of endoscopic stenting for dominant strictures in patients with primary sclerosing cholangitis
Authors: Han Samuel , Shah Raj J. 
Published: June 2022

Abstract
Background and study aims Dominant strictures (DS) occur in up to 60 % of patients with primary sclerosing cholangitis (PSC). Data regarding the long-term effects of stenting vs. dilation remain limited. The aim of this study was to compare the two treatment modalities in terms of transplantation-free survival.
Patients and methods This single-center, retrospective study examined patients with PSC and DS treated endoscopically with a minimum of 1 year follow-up. Patients were divided into two cohorts: 1) those who received dilation alone; and 2) those who received both dilation and stenting. The primary outcome was transplantation-free survival, defined as time after index ERCP to liver transplantation.
Results In all, 169 patients (54 in dilation cohort, 115 in stenting cohort) were included. The stenting cohort had a significantly higher Mayo PSC Risk Score (1.8 ± 1.1 vs. 0.9 ± 1.2) and presented with cholangitis more frequently (22.6 % vs. 1.9 %). During a follow-up period of 1198 person-years, 69 (40.8 %) patients received transplantation at a mean of 3.4 (± 2.9) years. There was no difference in transplantation rate in the stenting cohort [68 (95 % CI 5.2–8.8) per 100 person-years] compared to the dilation cohort [3.7 (95 % CI 2.1–6.0) per 100 person-years] and no difference in risk for transplantation (dilation cohort adjusted hazards ratio 0.67, 95 % CI 0.33–1.32).
Conclusions Despite a higher Mayo Risk Score in the stenting group, there was no difference in transplantation-free survival between patients managed with stenting vs. dilation alone. Stenting, therefore, may offer benefit in patients with advanced PSC and DS.
Comparison of Various Tosylating Reagents for the Synthesis of Mono-2-O-tosyl-β-cyclodextrin
Authors: Kordopati Golfo G. , Konstantinou Nikoletta-Melina , Tsivgoulis Gerasimos M. 
Published: June 2022

AbstractMono-2-O-tosyl-β-cyclodextrin is a key compound, as starting material, for the preparation of multifunctional systems in supramolecular chemistry. Although several methods are available in the literature for its synthesis, yields are always moderate (usually less than 42%) and reproducibility can be an issue as a result of the difficulties encountered in its preparation that are related to selectivity, monofunctionalization, solubility and purification, among others. A modification of a literature method was developed giving emphasis to simplicity and reproducibility and, for the first time, was tested with nine easily accessible tosylating reagents that differ significantly in their nature and reactivity. Product isolation was accomplished with precipitation followed by reverse-phase flash chromatography, which is easy to scale up. Interestingly, with the proposed method, all nine reagents can be successfully applied for the synthesis of the product with yields ranging from 33% to 40%. Optimum reaction times and temperatures were found and conclusions for each tosylating reagent are drawn.
(2-Aminoaryl)iminophosphoranes as Versatile Starting Materials for the Synthesis of 1-Aryl-2-trifluoromethylbenzimidazoles
Authors: Wróbel Zbigniew , Walewska-Królikiewicz Magdalena , Wilk Bogdan , Kwast Andrzej 
Published: June 2022

AbstractA new route to 2-(trifluoromethyl)benzimidazoles is described which involves the condensation of (2-arylamino)iminophosphoranes with trifluoroacetyl esters or trifluoroacetic anhydride. The method allows the synthesis of the title compounds from simple nitroarenes without the use of separate reduction steps and metallic reagents or expensive catalysts.
Scientometric Analysis of Top 100 Most Cited Articles on Imaging in COVID-19: The Pandemic of Publications
Authors: Jain Pooja , Aggarwal Ankita , Garg Kanwaljeet 
Published: June 2022

AbstractThe coronavirus disease 2019 (COVID-19) pandemic in 2020 was paralleled by an equally overwhelming publication of scientific literature. This scientometric analysis was performed to evaluate the 100 most cited articles on COVID-19 imaging to highlight research trends and identify common characteristics of the most cited works. A search of the Web of Science database was performed using the keywords “COVID CT,” “COVID Radiograph,” and “COVID Imaging” on June 29, 2021. The 100 top cited articles found were arranged in descending order on the basis of citation counts and citations per year and relevant data were recorded. Our search revealed a total of 4,862 articles on COVID-19 imaging published in the years 2020 to 2021. The journal with maximum number of publications (n = 22), citation count (n = 8,788), and impact was Radiology. Citations for the top 100 articles ranged from 70 to 1,742 with the most cited article authored by A.I. Tao and published in Radiology. Two authors tied at first spot, having maximum impact, with both having 5 publications and a total of 3,638 citations among them. China was the leading country with both the maximum number of publications (n = 49) and total citations (n = 13,892), the United States coming second in both. This study evaluates publication and citation trends in literature and shows that the countries most affected by the pandemic early on have contributed to the majority of the literature. Furthermore, it will help radiologists to refer to the most popular and important article texts on which to base their unbiased and confident diagnoses.
A Radiologists' Guide to En Bloc Resection of Primary Tumors in the Spine: What Does the Surgeon Want to Know?
Authors: Smith E. , Hegde G. , Czyz M. , Hughes S. , Haleem S. , Grainger M. , James S. L. , Botchu R. 
Published: June 2022

AbstractEn bloc resection in the spine is performed for both primary and metastatic bone lesions and has been proven to lengthen disease-free survival and decrease the likelihood of local recurrence. It is a complex procedure, which requires a thorough multi-disciplinary approach. This article will discuss the role of the radiologist in characterizing the underlying tumor pathology, staging the tumor and helping to predict possible intraoperative challenges for en bloc resection of primary bone lesions. The postoperative appearances and complications following en bloc resection in the spine will be considered in subsequent articles.
Hyperplastic Anterior Choroidal Artery—A Rare Variant Detected on MR Angiography
Authors: Shah Ankita U. , Joshi Anagha R. , Rai Pareekshith R. , Kapse Pratik 
Published: June 2022

Abstract
Introduction The anterior choroidal artery is a branch of the terminal internal carotid artery (ICA) that is often an incidentally detected anomaly. The hyperplastic variant has been linked with an increased risk of aneurysms. We explore the role of magnetic resonance (MR) angiography in the detection of this variant and its impact of presentation of patients.
Patient Presentation A 62-year-old diabetic and hypertensive male came to the casualty with complaints of giddiness, left-sided weakness, and loss of coordination for the last 2 to 3 days. He was provisionally diagnosed with a posterior circulation stroke.
Management and Outcome Magnetic resonance imaging of brain revealed an acute infarct in the right thalamus and the midbrain. Time-of-flight angiography sequences were done that showed hypoplasia of the A1 segment of the left anterior cerebral artery, fetal origin of the right posterior cerebral artery, narrowing of the left ICA, and a hyperplastic left anterior choroidal artery. He was managed conservatively with antiplatelets. He later underwent a digital subtraction angiography that revealed significant narrowing of the left ICA for which he was advised carotid stenting. However, the patient was unwilling for the procedure and was discharged on oral medication with stable vitals.
Conclusion Anatomical variations in the intracranial vasculature impact ischemia territory and the approach to intracranial pathology. Hyperplastic anterior choroidal artery results from the abnormal persistence of fetal pattern of vascular supply. It is important to recognize the presence of a hyperplastic anterior choroidal artery as it impacts both disease presentation and management of these patients. MR angiography allows for noninvasive and reliable detection of these anomalies in patients without the risks associated with radiation or contrast exposure in conventional/computed tomography angiography.
Development and verification of the coaxial heterogeneous hyperspectral imaging system
Authors: Tsai Y. H. , Yan Y. J. , Li Y. S. , Chang C. H. , Haung C. C. , Chen T. C. , Lin S. G. , Ou-Yang M. 
Published: June 2022

A hyperspectral imaging system (HIS) is a helpful tool that acquires spatial and spectral information from a target. This study developed a coaxial heterogeneous HIS (CHHIS) to collect spectral images with wavelengths ranging from 400 to 1700 nm. In this system, a visible (VIS) spectrometer and a short-wave infrared (SWIR) spectrometer are combined with a coaxial optical path to share the same field of view. This structure reduces the complexity of spatial registration and maintains the scanning duration of two spectrometers as that of a single spectrometer. The spectrometers are also replaceable for extending the detecting spectral range of the system. The calibration methodologies, including spatial correction, spectral calibration, and reflectance calibration, were developed for this system. The signal-to-noise ratio of VIS and SWIR spectrometers in the CHHIS was up to 40 and 60 dB when the exposure time of the VIS and SWIR imaging sensors was 1000 and 10 ms, respectively. When the target distance was at 600 mm, the spatial error of VIS and SWIR images in the scanning direction was less than 1 pixel; these results proved that the system was stable.
L2 tolerance of pragmatic violations of informativeness
Authors: Feng Shuo 
Published: June 2022

Abstract
This study sets out to investigate second language (L2) speakers’ derivation of pragmatic inferences and tolerance
of violations of informativeness in two types of inferences, i.e., ad hoc implicatures and contrastive inference. The results of a
graded judgment task revealed that pragmatic tolerance is inference-specific: L2 speakers were overly tolerant of underinformative
statements in ad hoc implicatures than in contrastive inference. In addition, L2 speakers were found to be more relaxed with
overinformativeness than underinformativeness in contrastive inference. The fact that L2 speakers tend to be redundant
(overinformative) than ambiguous (underinformative) is further discussed with the Pragmatic Principles Violation Hypothesis (Lozano, 2016). This study hopes to contribute to a more find-grained understanding of L2
speakers’ abilities of deriving pragmatic inferences.
Machine learning enhanced electrical impedance tomography for 2D materials
Authors: Coxson Adam , Mihov Ivo , Wang Ziwei , Avramov Vasil , Barnes Frederik Brooke , Slizovskiy Sergey , Mullan Ciaran , Timokhin Ivan , Sanderson David , Kretinin Andrey , Yang Qian , Lionheart William R B , Mishchenko Artem 
Published: June 2022

Abstract
Electrical impedance tomography (EIT) is a non-invasive imaging technique that reconstructs the interior conductivity distribution of samples from a set of voltage measurements performed on the sample boundary. EIT reconstruction is a non-linear and ill-posed inverse problem. Consequently, the non-linearity results in a high computational cost of solution, while regularisation and the most informative measurements must be used to overcome ill-posedness. To build the foundation of future research into EIT applications for 2D materials, such as graphene, we designed and implemented a novel approach to measurement optimisation via a machine learning adaptive electrode selection algorithm (A-ESA). Furthermore, we modified the forward solver of a python-based EIT simulation software, pyEIT, to include the complete electrode model (CEM) and employed it on 2D square samples (Liu B et al 2018 SoftwareX 7 304–8; Somersalo E et al 1992 SIAM J. Appl. Math.
52 1023–40). In addition, the deep D-Bar U-Net convolutional neural network architecture was applied to post-process conductivity map reconstructions from the GREIT algorithm (Hamilton and Hauptmann 2018 IEEE Trans. Med. Imaging
37 2367–77; Adler et al 2009 Physiol. Meas.
30 S35). The A-ESA offered around 20% lower reconstruction losses in fewer measurements than the standard opposite–adjacent electrode selection algorithm, on both simulated data and when applied to a real graphene-based device. The CEM enhanced forward solver achieved a 3% lower loss compared to the original pyEIT forward model. Finally, an experimental evaluation was performed on a graphene laminate film. Overall, this work demonstrates how EIT could be applied to 2D materials and highlights the utility of machine learning in both the experimental and analytical aspects of EIT.
Variation of receiver code biases under the influence of the receiver type and antenna configuration in the IGS network
Authors: Li Luohong , Zhang Xinyu , Yuan Yunbin 
Published: June 2022

Abstract
Receiver code biases (RCBs) are known to be time delays within the receiver caused by their hardware imperfections. To better understand the characteristics of RCBs, the un-combined (UC) and ionosphere-free (IF) precise point positioning functional models are adapted and re-parameterized to estimate the variation of RCBs as a time-variant parameter. In this study, we analytically studied the temporal variations of RCBs; although there exists a benchmark difference between the UC and IF models, their estimates are in accordance with each other. Additionally, this contribution assesses the inter-day stability of RCBs with weekly observations from 165 globally distributed international global navigation satellite system service stations equipped the receivers of three mainly types. The inter-day stability results of RCB revealed that the RCBs of POL2 and OUS2 have better stability over consecutive 7 d and the single differenced (SD) RCBs can reach 0.2 m in the best case. The results show that 74.83% of the stations are equipped with Trimble receivers under the condition that the mean SD RCB values are between −0.5 and 0.5 m, while 85.57% of the stations are equipped with Septentrio receivers and the stations equipped with Javad can reach 84.35% under this condition. The RCB estimates are also relatively stable for the case in which the receiver hardware device stays unchanged. The relationship between RCBs, receiver type, and antenna configuration is found using six groups of receivers. A strong correlation exists between RCBs, receiver type, and antenna configuration, which is more obvious among Septentrio receivers. The results show that the Pearson correlation coefficients were all higher than 0.9, and the standard deviation of between-receiver RCBs was smaller than 0.327 m when equipped with Septentrio receivers. We concluded that there is a strong relationship between the receiver-related pseudorange biases and the receiver and antenna setup.
Application of multi-angle millimeter-wave radar detection in human motion behavior and micro-action recognition
Authors: Zhang Zhaolin , Meng Wugang , Song Mingqi , Liu Yuhan , Zhao Yinan , Feng Xiang , Li Fengcong 
Published: June 2022

Abstract
Millimeter-wave radar is widely used in family safety, rehabilitation, and assisted living due to its ability to operate in all weathers and all day. To address the problem whereby the radar detection angle significantly impacts human behavior recognition, a recognition method based on multi-angle radar observation is adopted. We proposed a novel radar selection method called the energy domain ratio method to choose a radar with more sensitive features. Then, local tangent space alignment and an adaptive extreme learning machine (ELM) are presented to enhance the recognition rate of the model in a high-noise environment. A multi-angle entropy feature and an improved ELM are developed to identify human micro-motion in a low-noise indoor environment. The effect of observation distance on the recognition effect was also explored. The experimental results show that the proposed model has a more than 86% recognition rate for human behavior in outdoor scenes and a recognition accuracy of more than 98% for indoor micro-action.
Large area silicon drift detectors system for high precision timed x-ray spectroscopy
Authors: Miliucci M , Iliescu M , Sgaramella F , Bazzi M , Bosnar D , Bragadireanu M , Carminati M , Cargnelli M , Clozza A , Curceanu C , Deda G , De Paolis L , Del Grande R , Fiorini C , Guaraldo C , Iwasaki M , King P , Levi Sandri P , Marton J , Moskal P , Napolitano F , Niedźwiecki S , Piscicchia K , Scordo A , Shi H , Silarski M , Sirghi D , Sirghi F , Skurzok M , Spallone A , Tüchler M , Vazquez Doce O , Zmeskal J 
Published: June 2022

Abstract
The current work presents the optimization of large area silicon drift detectors developed by the SIDDHARTA-2 collaboration for high precision x-ray measurements of light exotic atom transitions. Two different radiation sources were employed in the study: an x-ray tube, for investigating the energy resolution and the charge collection efficiency of the device in the range 4000 eV–13 000 eV, and a β
−
90Sr radioactive source for measuring the timing response, thus qualifying the charge drift parameters inside the semiconductor. The study reports the spectroscopic response optimization, together with the tuning of the electron dynamics for the given Silicon technology, by adjusting the applied electric field and the working temperature, which allow a good control of the device’s performances for high precision, timed x-ray spectroscopy applications.