bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lumbar dynamic pedicle-based stabilization versus fusion in degenerative disease: a multicenter, double-blind, prospective, randomized controlled trial
Authors: Meyer Bernhard , Thomé Claudius , Vajkoczy Peter , Kehl Victoria , Dodel Richard , Ringel Florian , _ _ , _ _ , Meyer Bernhard , Ringel Florian , Behr Michael , Pape Haiko , Putzier Michael , Schuerings Marc , Thomé Claudius , Hartmann Sebastian , Vajkoczy Peter , Czabanka Marcus , Rohde Veit , von Eckardstein Kajetan , Börm Wolfgang , Zausinger Stefan , Sambale Rafael , Stoffel Michael , Richter Marcus , Arp Mirko , Bostelmann Richard , Meyer Frerk , Weber Fritz , Schulte Tobias , Spetzger Uwe , Müller Andreas , Wirtz Rainer , Dodel Richard , Evers Janis , André Elisabeth , Zollner Alfred , Kehl Viktoria 
Published: April 2022

OBJECTIVE
Fusion is the standard of treatment for degenerative lumbar symptomatic instabilities. Dynamic stabilization is a potential alternative, with the aim of reducing pathological motion. Potential advantages are a reduction of surgical complexity and morbidity. The aim of this study was to assess whether dynamic stabilization is associated with a higher degree of functional improvement while reducing surgical complexity and thereby surgical duration and perioperative complications in comparison with lumbar fusion.

METHODS
This was a multicenter, double-blind, prospective, randomized, 2-arm superiority trial. Patients with symptomatic mono- or bisegmental lumbar degenerative disease with or without stenosis and instability were randomized 1:1 to instrumented fusion or pedicle-based dynamic stabilization. Patients underwent either rigid internal fixation and interbody fusion or pedicle-based dynamic stabilization. The primary endpoint was the Oswestry Disability Index (ODI) score, and secondary endpoints were pain, health-related quality of life, and patient satisfaction at 24 months.

RESULTS
Of 293 patients randomized to fusion or dynamic stabilization, 269 were available for analysis. The duration of surgery was significantly shorter for dynamic stabilization versus fusion, and the blood loss was significantly less for dynamic stabilization (380 ml vs 506 ml). Assessment of primary and secondary outcome parameters revealed no significant differences between groups. There were no differences in the incidence of adverse events.

CONCLUSIONS
Dynamic pedicle-based stabilization can achieve similar clinical outcome as fusion in the treatment of lumbar degenerative instabilities. Secondary failures are not different between groups. However, dynamic stabilization is less complex than fusion and is a feasible alternative.
Longitudinal assessment of segmental motion of the cervical spine following total disc arthroplasty: a comparative analysis of devices
Authors: Colman Matthew W. , Zavras Athan G. , Federico Vincent P. , Nolte Michael T. , Butler Alexander J. , Singh Kern , Phillips Frank M. 
Published: April 2022

OBJECTIVE
Total disc arthroplasty (TDA) has been shown to be an effective and safe treatment for cervical degenerative disc disease at short- and midterm follow-up. However, there remains a paucity of literature reporting the differences between individual prosthesis designs with regard to device performance. In this study, the authors evaluated the long-term maintenance of segmental range of motion (ROM) at the operative cervical level across a diverse range of TDA devices.

METHODS
In this study, the authors retrospectively evaluated all consecutive patients who underwent 1- or 2-level cervical TDA between 2005 and 2020 at a single institution. Patients with a minimum of 6 months of follow-up and lateral flexion/extension radiographs preoperatively, 2 months postoperatively, and at final follow-up were included. Radiographic measurements included static segmental lordosis, segmental range of motion (ROM) on flexion/extension, global cervical (C2–7) ROM on flexion/extension, and disc space height. The paired t-test was used to evaluate improvement in radiographic parameters. Subanalysis between devices was performed using one-way ANCOVA. Significance was determined at p < 0.05.

RESULTS
A total of 85 patients (100 discs) were included, with a mean patient age of 46.01 ± 8.82 years and follow-up of 43.56 ± 39.36 months. Implantations included 22 (22.00%) M6-C, 51 (51.00%) Mobi-C, 14 (14.00%) PCM, and 13 (13.00%) ProDisc-C devices. There were no differences in baseline radiographic parameters between groups. At 2 months postoperatively, PCM provided significantly less segmental lordosis (p = 0.037) and segmental ROM (p = 0.039). At final follow-up, segmental ROM with both the PCM and ProDisc-C devices was significantly less than that with the M6-C and Mobi-C devices (p = 0.015). From preoperatively to 2 months postoperatively, PCM implantation led to a significant loss of lordosis (p < 0.001) and segmental ROM (p = 0.005) relative to the other devices. Moreover, a significantly greater decline in segmental ROM from 2 months postoperatively to final follow-up was seen with ProDisc-C, while segmental ROM increased significantly over time with Mobi-C (p = 0.049).

CONCLUSIONS
Analysis by TDA device brand demonstrated that motion preservation differs depending on disc design. Certain devices, including M6-C and Mobi-C, improve ROM on flexion/extension from preoperatively to postoperatively and continue to increase slightly at final follow-up. On the other hand, devices such as PCM and ProDisc-C contributed to greater segmental stiffness, with a gradual decline in ROM seen with ProDisc-C. Further studies are needed to understand how much segmental ROM is ideal after TDA for preservation of physiological cervical kinematics.
Segmental range of motion after cervical total disc arthroplasty at long-term follow-up: a systematic review and meta-analysis
Authors: Zavras Athan G. , Dandu Navya , Nolte Michael T. , Butler Alexander J. , Federico Vincent P. , Sayari Arash J. , Sullivan T. Barrett , Colman Matthew W. 
Published: April 2022

OBJECTIVE
As an alternative procedure to anterior cervical discectomy and fusion, total disc arthroplasty (TDA) facilitates direct neural decompression and disc height restoration while also preserving cervical spine kinematics. To date, few studies have reported long-term functional outcomes after TDA. This paper reports the results of a systematic review and meta-analysis that investigated how segmental range of motion (ROM) at the operative level is maintained with long-term follow-up.

METHODS
PubMed and MEDLINE were queried for all published studies pertaining to cervical TDA. The methodology for screening adhered strictly to the PRISMA guidelines. All English-language prospective studies that reported ROM preoperatively, 1 year postoperatively, and/or at long-term follow-up of 5 years or more were included. A meta-analysis was performed using Cochran’s Q and I2 to test data for statistical heterogeneity, in which case a random-effects model was used. The mean differences (MDs) and associated 95% confidence intervals (CIs) were reported.

RESULTS
Of the 12 studies that met the inclusion criteria, 8 reported the long-term outcomes of 944 patients with an average (range) follow-up of 99.86 (60–142) months and were included in the meta-analysis. There was no difference between preoperative segmental ROM and segmental ROM at 1-year follow-up (MD 0.91°, 95% CI −1.25° to 3.07°, p = 0.410). After the exclusion of 1 study from the comparison between preoperative and 1-year ROM owing to significant statistical heterogeneity according to the sensitivity analysis, ROM significantly improved at 1 year postoperatively (MD 1.92°, 95% CI 1.04°–2.79°, p < 0.001). However, at longer-term follow-up, the authors again found no difference with preoperative segmental ROM, and no study was excluded on the basis of the results of further sensitivity analysis (MD −0.22°, 95% CI −1.69° to −1.23°, p = 0.760). In contrast, there was a significant decrease in ROM from 1 year postoperatively to final long-term follow-up (MD −0.77°, 95% CI −1.29° to −0.24°, p = 0.004).

CONCLUSIONS
Segmental ROM was found to initially improve beyond preoperative values for as long as 1 year postoperatively, but then ROM deteriorated back to values consistent with preoperative motion at long-term follow-up. Although additional studies with further longitudinal follow-up are needed, these findings further support the notion that cervical TDA may successfully maintain physiological spinal kinematics over the long term.
Early surgical versus endovascular repair of ruptured blood-blister aneurysm of the internal carotid artery: a single-center 20-year experience
Authors: Eide Per K. , Sorteberg Angelika , Nome Terje , Rønning Pål A. , Sorteberg Wilhelm 
Published: April 2022

OBJECTIVE
Early repair of ruptured blood-blister aneurysms (BBAs) of the internal carotid artery (ICA) remains challenging. Although both surgical and endovascular therapies have been established, their relative superiority remains debated. The authors assessed their single-center experience and compared early deconstructive versus reconstructive repair and early reconstructive surgical versus endovascular repair of ruptured BBAs of the ICA.

METHODS
The study included patients who underwent repair of ruptured BBAs of the ICA within 1 week after the ictus during a 20-year period. Multiple variables were recorded, including clinical state, severity of subarachnoid hemorrhage (SAH), characteristics of the BBA, treatment details, complication profile, need for secondary treatment, and clinical outcome.

RESULTS
In total, 27 patients underwent early surgical (n = 16) or endovascular (n = 11) repair of BBAs at a median of 24 hours (range 9–120 hours) after the ictus during the period from September 2000 to June 2021 (20.4 years). Primary deconstructive repair (n = 6) without bypass was accompanied by middle cerebral artery (MCA) territory infarction in 5 of 6 (83%) patients and a high mortality rate (4/6 [67%]). Among the 21 patients who underwent early reconstructive repair, surgery was performed in 11 patients (clipping in 6 and clip-wrapping in 5 patients) and endovascular repair in 10 patients (flow diversion in 7 and stent/stent-assisted coiling in 3 patients). No differences were found in complication profiles or clinical outcomes between the surgical and endovascular groups. The mortality rate was low (2/21 [9.5%]), with 1 fatality in each group.

CONCLUSIONS
From the authors’ experience, both surgical and endovascular approaches permitted reconstructive repair of ruptured BBAs of the ICA, with no modality proving superior. Reconstructive treatment is preferable to ICA sacrifice, and if sacrifice is chosen, it should be accompanied with bypass surgery or delayed to the phase when cerebral vasospasm has resumed. The rare occurrence of this disease calls for prospective multicenter studies to improve treatment and delineate which modality is preferable in individual cases.
Pendidikan Pembebasan (Studi Pemikiran Paulo Freire dan KH Ahmad Dahlan)
Authors: Salim Hani Muhammad Abdul , Ilham Ilham 
Published: April 2022

Pendidikan merupakan salah satu unsur yang penting dalam rangka meningkatkan Sumber Daya Manusia. Sumber Daya manusia itu, sebagai indikator untuk menilai negara dapat dikategorikan sebagai Negara maju atau sebagai Negara berkembang. Namun, dalam perkembangnya dunia pendidikan berkolaborasi dengan dengan dunia industri, sehingga manajerial disetarakan dengan perusahaan. Kebijakan yang diambil oleh pemerintah tersebut menjadikan pendidikan diorientasikan pada pasar, sehingga melahirkan “robot-robot” manusia dan mahalnya biaya pendidikan. Dalam rangka menanggulangi persoalan tersebut, maka diperlukan konsep pendidikan pembebasan. Artikel ini, ingin mengkaji pemikiran pendidikan dari Paulo Feire dan KH Ahmad Dahlan sehingga dapat memberikan kontribusi terhadap persoalan tersebut. Hasil dari kajian ini, mendeskripsikan bahwa keduanya menjadikan pendidikan sebagai sarana untuk mengembangkan manusia sehingga mampu bersama dengan lingkungannya melakukan perubahan sosial. Sitem pendidikan yang dilaksanakan dilakukan secara diologis dan sesuai dengan kebutuhan peserta. Pemikiran dan pelaksanaan pendidikan pembebasan Paulo Freire tidak berkembang dengan baik dan autopis. Hal ini, berbeda dengan pemikiran pendidikannya berkembang dengan melahirkan berbagai lembaga pendidikan di Indonesia.Education is an essential element in improving Human Resources. In its development, education collaborates with industrialization, where the management of education is equal to that of companies. This policy makes education market-oriented. This can give birth to human "robots," and the cost of education is expensive. This problem can be faced by designing and the necessary concept of education liberation. This article examined Paulo Freire and KH Ahmad Dahlan's educational thoughts regarding the idea of education liberation as a contribution to educational problems. This research was a qualitative study using a descriptive-critical approach. Methods of data collection using documentation and literature. Methods of data analysis using data reduction, data display, and conclusions. The results of this study described that KH. Ahmad Dahlan and Paulo Freire used education to develop people so that they could make social change. The education system is implemented in a dialogical manner and in accordance with the needs of the participants. Paulo Freire's thinking and application of liberation education were not well developed and atopic. In contrast, Ahmad Dahlan's thought and application of education were developed by creating various educational institutions in Indonesia.
Pengaruh Media Sosial Terhadap Wawasan Kebangsaan Pada Generasi Muda
Authors: Mergining Mei Nanang Andhiyan , Farida Elis Anita , Kridaningsih Anna 
Published: April 2022

Penggunaan media sosial bagi generasi muda dapat meningkatkan interaksi antar penggunanya tanpa terbatas jarak dan waktu. Kemudahan melakukan interaksi memberikan dampak dengan semakin mudahnya untuk berkomunikasi baik menyampaikan berita/pesan dan memberikan respon berupa kritik maupun saran. Salah satu dampak negatif yang dapat terjadi yaitu menyampaikan pesan berupa ajakan untuk menamamkan ujaran kebencian terkait dengan kehidupan berbangsa dan bernegara. Penelitian dilakukan untuk mengkaji tentang pengaruh media sosial terhadap wawasan kebangsaan pada generasi muda di Kelurahan Gunung Gedangan Kota Mojokerto. Penelitian survey dengan variabel bebas (X) yaitu media sosial dan variabel terikat (Y) yaitu wawasan kebangsaan. Berdasarkan hasil olah data diperoleh signifikansi (Sig) sebesar 0,020 < 0,05 sehingga disimpulkan bahwa media sosial (X) berpengaruh terhadap wawasan kebangsaan (Y).
FAKTOR-FAKTOR YANG MEMPENGARUHI TERJADINYA MERARIQ PADA MASYARAKAT SUKU SASAK
Authors: Haslan Muhammad Mabrur , Dahlan Dahlan , Fauzan Ahmad 
Published: April 2022

Tujuan penelitian ini adalah untuk mengidentifikasi faktor-faktor yang mempengaruhi terjadinya merariq pada masyarakat suku sasak. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kualitatif dengan metode deskriptif. Teknik Pengumpulan Data yang digunakan adalah, wawancara mendalam, observasi dan dokumentasi. Hasil penelitian faktor-faktor yang mempengaruhi terjadinya merariq pada masyarakat suku sasak sebagai berikut: (1) perbedaan strata atau kelas (2) faktor budaya yang dilakukan secara turun temurun. 3) faktor ekonomi (4) faktor persaingan. (5) faktor perjodohanThe purpose of this study is: (1) to identify factors influence merariq at Sasak Tribe Community. The method of research in the shape case study. Meanwhile the technique in collecting the data is in-depth interview, obervation, and documentation. Furthermore data analysis conducted completely during data collection in very focus of activities and every finishing data collection. The Results of research to identify factors influence merariq at Sasak Tribe Community etc (1) discrimination strata and class fa(2) hereditary culture factors (3) economic factors (4) competition factors (5) matchmaking factors
Penerapan Metode Balanced Scorecard Sebagai Pengukuran Kinerja pada Kantor SAMSAT Selong
Authors: Zahra Sania Al , Yuliati Ni Nyoman , Wahyullah Muhammad 
Published: April 2022

Abstrak: Penelitian ini bertujuan untuk mengetahui Kinerja Kantor SAMSAT Selong diukur dengan menggunakan Metode Balanced Scorecard. Jenis penelitian ini adalah penelitian deskriptif. Teknik pengambilan sampel yang digunakan adalah nonprobability sampling. Hasil penelitian diukur menggunakan value for money dengan hasil yang baik, persepektif pelanggan menunjukkan hasil yang baik berdasarkan 3 indikator, persepektif proses bisnis internal menunjukkan hasil yang sangat baik berdasarkan 7 indikator, serta persepektif pembelajaran dan pertumbuhan menunjukkan hasil yang baik. Kantor SAMSAT Selong harus lebih memperhatikan kualitas pelayanan dengan baik terhadap pelanggan dan meningkatkan kinerja terhadap pegawai.Abstract: This study aims to determine the performance of the Selong SAMSAT Office when measured using the Balanced Scorecard Method. This type of research is descriptive research. Where customers are taxpayers, the sample is taken by using incidental sampling and the employees of the Selong SAMSAT office using saturated sampling. The results using value for money with good results, the customer perspective shows good results based on 3 indicators, the internal business process perspective shows excellent results based on 7 indicators, as well as the learning and teaching perspective. growth shows good results. The Selong SAMSAT Office should pay more attention to the quality of service to customers and improve performance of employees.
A Phase 2 Study of S-588410 Maintenance Monotherapy for Platinum-Treated Advanced or Metastatic Urothelial Carcinoma
Authors: Shimizu Nobuaki , Hussain Syed A. , Obara Wataru , Yamasaki Toshinari , Takashima Satoru , Hasegawa Takahiro , Iguchi Motofumi , Igarashi Kenji , Ogawa Osamu , Fujioka Tomoaki 
Published: April 2022

BACKGROUND: Effective maintenance therapy for urothelial carcinoma (UC) is needed to delay progression after first-line chemotherapy. OBJECTIVE: To evaluate S-588410, a cancer peptide vaccine containing five human leukocyte antigen (HLA)-A*24:02-restricted epitope peptides derived from five cancer-testis antigens (DEPDC1, MPHOSPH1, URLC10, CDCA1, and KOC1) in chemotherapy-treated, clinically stable patients with advanced or metastatic UC. MATERIALS AND METHODS: This open-label, international, phase 2 trial enrolled patients with UC who had completed≥4 cycles of first-line platinum-containing chemotherapy without disease progression. Forty-five HLA-A*24:02-positive patients received subcutaneous injections of S-588410 (Montanide ISA 51 VG with 1 mg/mL of each peptide) weekly for 12 weeks then once every 2 weeks thereafter for up to 24 months. Thirty-six HLA-A*24:02-negative patients did not receive S-588410 (observation group). The primary endpoint was the rate of cytotoxic T-lymphocyte (CTL) induction against≥1 of the peptides at 12 weeks. RESULTS: The CTL induction rate in the S-588410 group was 93.3% ( p < 0.0001, one-sided binomial test with a rate of≤50% as the null hypothesis). The antitumor response rate was 8.9% in the S-588410 group and 0% in the observation group; median progression-free survival was 18.1 versus 12.5 weeks and median overall survival was 71.0 versus 99.0 weeks, respectively. The most frequent treatment-emergent adverse event was injection-site reactions (47 events, grades 1–3) reported in 93.3% ( n = 42/45) of participants. CONCLUSIONS: S-588410 demonstrated a high CTL induction rate, acceptable safety profile, and modest clinical response, as maintenance therapy in participants with advanced or metastatic UC who had received first-line platinum-based chemotherapy (EudraCT 2013-005274-22).
A New Functional Gene, Zinc Finger Protein 485 (ZNF485), is Involved in Bladder Cancer Proliferation
Authors: Tan Yiao , Zhao Fangfang , Liu Shuhan , Huang Tao , Zang Chunbao , Sha Dan , Kong Lingsuo , Ge Fangfang , Huang Dabing , Pu Youguang 
Published: April 2022

BACKGROUND: Bladder cancer is the second most common urological cancer worldwide, with low early diagnosis and high mortality. The limited progress in diagnostics and treatment greatly impedes the survival of bladder cancer patients. OBJECTIVE: Potential therapeutic biomarkers are urgently needed for future clinical treatment. METHODS: We analyzed the sequencing data and corresponding clinicopathological features and survival information of bladder cancer patients in the TCGA database and identified a new zinc finger protein 485 gene, termed ZNF485, which is highly expressed in the tissues of bladder cancer patients and was verified in cells, animal models and tissue microarrays. RESULTS: We found that inhibition of ZNF485 in the bladder cancer cell lines T24 and 5637 obviously inhibited proliferation and promoted the apoptosis of cancer cells. Furthermore, wound healing and invasion assays showed that downregulation of ZNF485 significantly decreased the mobility and invasion of T24 and 5637 cells. In addition, ZNF485-shRNA transfection obviously inhibited tumor growth in nude mice. Immunohistochemical results of clinical samples showed that the expression level of ZNF485 protein in cancer tissues was higher than that in adjacent tissues. Mechanistic analysis identified possible downstream target genes. CONCLUSIONS: Taken together, the results provide evidence that ZNF485 is involved in bladder cancer proliferation and might be a potential therapeutic biomarker for the treatment of this disease
National Social Security Fund of Kenya: An Assessment from Islamic Jurisprudence
Authors: Manswab Mahsen Abdulrahman  
Published: April 2022

The social security fund operated as a community collective system prior to the colonial period. The colonial government proposed establishing a provident fund for African workers. They noted that the pension scheme was not favorable because it required the investment of significant resources and subsidies by the government. Following independence, the Kenyan government announced the implementation of social security for its people. The National Social Security Fund (NSSF) was established by an Act of parliament Cap 258 in November 1965, however, contributions began in July 1966 to allow it to operate as the National Provident Fund. Since her independence Kenya has undergone several pension reforms, culminating in the enactment of the NSSF Act in 2013. The pension scheme has received significant attention from the Muslim clerics. Some fatawa have been issued stating that the retirement benefits are not Sharī‘ah compliant. This situation might jeopardize the retirement goal and put the retirees in financial difficulty by denying them their benefits. The main objective of this study is to evaluate the conformity of Sharī‘ah in Kenya’s pension fund operation. Inductive method was used to examine the operational methods of the social security fund from both the perspectives of pension scheme and Islamic jurisprudence in order to mutually integrate them. Likewise, the researchers used the analytical approach to clarify the opinions of the Muslim scholars regarding the pension scheme products and to highlight some areas of inconsistency with Islamic law in order to provide Islamic alternatives. The results showed that pension scheme funds are inconsistent with Islamic law. Therefore, it is recommended for NSSF to open Islamic windows to meet the demands of the Muslim workers seeking Sharī‘ah compliant products / services.