bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Dynamics of the Pesantren Adaptation Patterns Amid the Covid-19 Pandemic
Authors: Kholifah Siti 
Published: July 2022

The Covid-19 pandemic has made many changes in all spheres including in education. To minimize the spread of Covid-19, the Indonesian government issued a policy for student to study at home, and since March 16, 2020 schools have implemented online learning methods. However, this cannot be applied to the education system of pesantren (Islamic boarding schools) due to limitations in access and use technology of information, as well as digital literacy. In addition economic considerations, make pesantren continue for conducting offline learning. Therefore, this study focuses on how the process of adapting pesantren in handling the Covid-19 pandemic? This study aims to determine and analyze the pattern of adaptation of pesantren in carrying out activities during the pandemic. The research was conducted at the Ar-Rohmah pesantren, Malang City as a modern pesantren that is part of ‘the pesantren tangguh’ program. By using Robert K. Merton’s theory as an analytical tool, this research conducted an explanatory case study. Data collection techniques carried out through observation, documentation, and in-depth interviews with informants are determined purposively. The results of this study showed that at the beginning of the pandemic, the adaptation of pesantren tended to conformity pattern with longer school holidays to minimize the spread of Covid-19. At the beginning of re-entry, the Ar-Rohmah pesantren’s adaptation tended to an innovation pattern by conducting offline learning with health protocols that are not strict. After an ustadz passed away and he was confirmed as positively infected Covid-19, the adaptation process carried out was more conformity by conducting blended learning and all pesantren’s members more adhered to health protocols. However, in June 2021 Ar-Rohmah pesantren tend to be innovation pattern with pesantren activities that are carried out offline, which can be followed by community around the pesantren.
Application of the diagnostic criteria for Common Variable Immunodeficiency in resource-limited settings
Authors: Álvarez-Álvarez Jesús A. , Gallon Duque Alejandro , Vásquez-Echeverri Estefanía , Sánchez Isaura P. , Gutierrez Hincapié Sebastián , Gómez-Arias Rubén D. , Orrego Arango Julio C. , Franco José L. , Trujillo-Vargas Claudia M. 
Published: July 2022

Introduction: Common variable immunodeficiency (CVID) is the most prevalent symptomatic humoral deficiency; however, its heterogeneous presentation makes the diagnosis difficult. The present study is aimed to verify the CVID diagnostic criteria as established by the European Society for Immunodeficiencies in 42 CVID patients from our outpatient clinic.
Methods: Information was collected from their medical records and when needed, lymphocyte subpopulations in peripheral blood (PB) were performed by flow cytometry.
Results: All the patients fulfilled the clinical working definition for CVID and showed decreased serum IgG and IgA at diagnosis. Over two-thirds of the patients had decreased memory B cell percentages. However, the remaining patients exhibited other quantitative B cell defects in PB. Evaluation of vaccination responses was only found in 13 records and 69% were not responsive. None of the patients were subjected to vaccination studies to both, T-cell dependent and independent antigens. The two required tests to evaluate T cell responses were performed in 84.2% of the patients and reported normal. Without the support of third-party payers, only 34.2% of our patients would have completed the required evaluations.
Conclusions: Further efforts are needed to speed up CVID diagnosis in low-resourced settings, increasing the availability of the required resources and optimizing the healthcare supply chain.
COmparisoN of TastES of Available NutriTional integrated or non-integrated formulas for infants older than 1 year of age with cow’s milk allergy: A multicenter, prospective, single blind, cross-sectional observational clinical study (CONTEST Study)
Authors: Altıntas Derya Ufuk , Turktas Ipek , Arga Mustafa , Cokugras Haluk Cezmi , Civelek Ersoy , Keskin Ozlem , Buyuktiryaki Betul , Ertem Deniz , Aydogan Metin , Ecevit Cıgdem Omur , Ozturk Yesim , Tamay Zeynep , Yucel Esra , Caltepe Gonul , Beser Omer Faruk , Guler Nermin 
Published: July 2022

Palatability of the infant formulas lacking cow milk protein formulas is reported by parents to be an important drawback. The purpose of this study is to examine decisions made by mothers of infants having cow milk protein allergy, and physicians concerning the palatability of unflavored extensively hydrolyzed formulas and amino acid-based formulas. We conducted a multi-center, randomized, single-blinded, observational taste study involving 149 pediatricians from gastroenterology and allergy subspecialties at 14 tertiary healthcare units from different regions of Turkey and involving 94 mothers of infants with cow milk protein allergy. Blinding was performed for seven formulas available in the market, which were the most commonly prescribed for feeding: four AAFs (Neocate-Numil®, Aptamil Pregomin AS-Numil®, Alfamino-Nestle®, Comidagen-Mamma®), one AAF specifically designed to address the growing nutritional and lifestyle needs of children >1 year (Neocate Junior-Numil®), 2 eHFs (Bebelac Pepti Junior-Numil®, Similac Alimentum-Abott®). Considering all three formula characteristics, Neocate junior-Numil® ranked as the number 1 product among seven products by mothers (63.8%) and physicians (69.8%). The ratings of mothers were significantly higher than the physicians (8.1 points and 6.1 points, respectively; p < 0.001). No difference was found in terms of taste, smell, and appearance for Neocate junior-Numil® between the mothers’ and physicians’ ratings. Since caregivers have responsibility for careful selection of replacement products for infants with cow milk protein allergy, it is noteworthy that increased awareness and confidence in the palatability characteristics of these products should motivate mothers and physicians to comply with replacement treatment in the long term.
Immunological differences between atopic dermatitis, psoriasis, and their combination in adult patients
Authors: Krupka-Olek Magdalena , Bozek Andrzej , Drewienkowska Milena , Dryjka Krzysztof , Medrala Agata 
Published: July 2022

Objectives: The simultaneous occurrence of psoriasis (PS) dominated by Th1 lymphocytes and atopic dermatitis (AD) driven by Th2 cells is rare. This study analyzed a group of adult patients with concomitant PS and AD (ADPS) and compared the cytokine profiles of these patients with those of subjects with homogenous PS or AD and healthy controls.
Materials and methods: All patients underwent dermatological examinations, including assessment of Scoring Atopic dermatitis (SCORAD) index and Psoriasis Area Severity Index (PASI) scores, TNF-α, IFN-γ, Il-2, Il-4, Il-5, Il-6, Il-8, Il-12, I-17A, Il-18, Il-22, Il-33, and T. There were 39 patients with a diagnosis of ADPS, 45 patients with PS, 47 patients with AD, and 42 healthy controls.
Results: Patients with ADPS were mainly men with a proportional distribution of skin lesion areas. Significant differences were observed in the concentration of Il-17A between patients with ADPS and those with AD or PS and controls, which were as follows: 16.1 ± 5.4, 5.8 ± 2.1, 5.0 ± 3.1, and 3.3 ± 1.8 pg/mL, respectively. In conclusion, AD and PS might coexist as a combination disease. The role of T helper 17 cells may be more essential than previously thought.
Risk taking and self-care behaviours amongst adolescents and young adults with food allergies
Authors: Keohane Hannah , Cronin Caoimhe , Trujillo Juan 
Published: July 2022

Background: Anaphylaxis is a systemic, life-threatening reaction and its prevalence is rising amongst adolescents and young adults (AYA) with food allergies. The likelihood of fatal anaphylaxis is disproportionately high in this population. The effective management of anaphylaxis can be done by adhering to various food allergy-related self-care behaviours, namely avoidance of allergens, carriage and use of adrenaline auto-injectors (AAI). Unfortunately, compliance of AYA to these behaviours is believed to be suboptimal and the likely reason behind their increased rates of fatal anaphylaxis.
Methodology: To evaluate the adherence to food allergy-related self-care behaviours amongst adolescents and young adults with anaphylaxis an electronic search was conducted utilizing PubMed, MEDLINE, and CINAHL plus to identify relevant studies. 175 article abstracts were screened, and 26 remained which were read in full to determine which best satisfied the inclusion and exclusion criteria. Ultimately, 10 articles were selected for this review.
Results: The compliance to food allergy-related self-care behaviours amongst AYA founded to be suboptimal. AAI design, peer influence, and emotional attitudes of AYA were found to be the most significant factors influencing AYA compliance to self-care behaviours.
Conclusions: The adherence of AYA to food allergy-related self-care behaviours is suboptimal and evidence on the factors affecting AYA compliance has been largely contradictory. AAI design, peer influence, and emotional attitudes are significant factors influencing AYA adherence. Therefore, further research directed at these factors is imperative in facilitating the design of guidelines to maximize the adherence of AYA to food allergy-related self-care behaviours.
Knockdown of CXCL3-inhibited apoptosis and inflammation in lipopolysaccharide-treated BEAS-2B and HPAEC through inactivating MAPKs pathway
Authors: Wang Yuhui , Pan Linyan 
Published: July 2022

Background: CXCL3 (C-X-C motif chemokine ligand 3) is a member of chemokines family, which binds to the receptor to recruit neutrophils to lungs, thus participating in the pathogenesis of asthmatic lung. The role of CXCL3 in sepsis-induced acute lung injury is investigated here.
Methods: Human lung epithelial cell line (BEAS-2B) and human pulmonary artery endothelial cell line (HPAEC) were treated with lipopolysaccharides (LPS). MTT and flow cytometry were performed to detect cell viability and apoptosis, respectively. Enzyme-linked immunosorbent assay (ELISA) and real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) were used to assess the levels of inflammatory factors.
Results: Treatment with LPS resulted in the decrease of cell viability in BEAS-2B and HPAEC. CXCL3 was particularly upregulated in LPS-treated BEAS-2B and HPAE cells. Knockdown of CXCL3 enhanced viability and suppressed apoptosis i006E LPS-treated BEAS-2B and HPAE cells. Knockdown of CXCL3 also upregulated TNF-α, IL-1β, and IL-18 in LPS-treated BEAS-2B and HPAE cells. Moreover, knockdown of CXCL3 suppressed the activation of mitogen-activated protein kinases (MAPKs) signaling in LPS-treated BEAS-2B and HPAE cells through downregulation of p-ERK1/2, p-p38, and p-JNK. On the other hand, overexpression of CXCL3 caused completely opposite results in LPS-treated BEAS-2B and HPAE cells.
Conclusion: Knockdown of CXCL3 exerted antiapoptotic and anti-inflammatory effects against LPS-treated BEAS-2B and HPAE cells, at least partially, through inactivation of MAPKs signaling, suggesting a potential strategy for the intervention of sepsis-induced acute lung injury.
6'-O-galloylpaeoniflorin alleviates inflammation and oxidative stress in pediatric pneumonia through activating Nrf2 activation
Authors: Xu Cheng , Song Lei , Zhang Weiyan , Zou Rong , Zhu Meijun 
Published: July 2022

Objective: To assess the therapeutic effect and mechanism of 6'-o-galloylpaeoniflorin (GPF) in pediatric pneumonia.
Methods: The effects of lipopolysaccharide (LPS) and GPF on cell viability and apoptosis were examined by cell counting kit-8 assay and flow cytometry analysis. The oxidative stress and inflammatory response were assessed by detecting expression levels of superoxide dismutase, glutathione, r-glutamyl cysteingl+glycine, myeloperoxidase, and malondialdehyde as well as tumor necrosis factor-α, Interleukin-18, and Interleukin-10 by using enzyme-linked-immunosorbent serologic assay. Moreover, the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) pathway was detected by immunoblot assay, and the influence of Nrf2-knockdown on cell viability, oxidative stress, and inflammation response was also investigated.
Results: The results established that GPF increased the viability of LPS-induced pneumonia cells. In addition, GPF reduced LPS-induced oxidative stress in pneumonia cells. It was further discovered that GPF reduced LPS-induced inflammation in pneumonic cell. GPF improved the activity of Nrf2 in LPS-treated pneumonic cells, and therefore alleviated inflammation and oxidative stress in pediatric pneumonia.
Conclusion: GPF could serve as a promising drug for treating pediatric pneumonia.
Experiences of Transcendence in Guided Imagery & Music (GIM) – An Intersubjective Perspective
Authors: Mårtenson Blom Katarina 
Published: July 2022

In this paper, the author describes a perspective on experiences of transcendence in GIM through an integrative description of a clinical case study of GIM transcripts and a PhD study. The article summarizes results from both and develops a reflecting discussion in relation to the author’s continued post-doctoral clinical and teaching experiences. The developed perspective focuses on the process in GIM when experiences of transcendence occur and juxtaposes that to the contents of such experiences. This is argued for in terms of an intersubjective, interactive perspective on how the process among therapist, music, and client moves and deepens.
Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy
Authors: López-Cayuqueo Karen I. , Planells-Cases Rosa , Pietzke Matthias , Oliveras Anna , Kempa Stefan , Bachmann Sebastian , Jentsch Thomas J. 
Published: July 2022

Significance Statement
Kidney cells are exposed to large changes in osmolarity and hence require efficient volume regulation. Volume-regulated anion channels (VRACs) mediate regulatory volume decrease, but their expression and function in the kidney remain enigmatic. VRACs, heterohexamers of LRRC8 proteins, also conduct metabolites. This paper describes the renal expression pattern of all five LRRC8 subunits and explores their roles in mouse models. Except for vasculature-restricted LRRC8C, all LRRC8 proteins are found along the nephron. Rather than in medulla, which experiences large osmolarity changes, VRACs are most highly expressed in proximal tubules, which have metabolite-conducting LRRC8A/D channels. Targeted disruption of either subunit injures the proximal tubule and produces Fanconi-like symptoms. VRACs may mediate nonspecific exit of organic compounds in this highly transporting nephron segment.

Background
Volume-regulated anion channels (VRACs) are heterohexamers of LRRC8A with LRRC8B, -C, -D, or -E in various combinations. Depending on the subunit composition, these swelling-activated channels conduct chloride, amino acids, organic osmolytes, and drugs. Despite VRACs’ role in cell volume regulation, and large osmolarity changes in the kidney, neither the localization nor the function of VRACs in the kidney is known.

Methods
Mice expressing epitope-tagged LRRC8 subunits were used to determine the renal localization of all VRAC subunits. Mice carrying constitutive deletions of Lrrc8b–e, or with inducible or cell-specific ablation of Lrrc8a, were analyzed to assess renal functions of VRACs. Analysis included histology, urine and serum parameters in different diuresis states, and metabolomics.

Results
The kidney expresses all five VRAC subunits with strikingly distinct localization. Whereas LRRC8C is exclusively found in vascular endothelium, all other subunits are found in the nephron. LRRC8E is specific for intercalated cells, whereas LRRC8A, LRRC8B, and LRRC8D are prominent in basolateral membranes of proximal tubules. Conditional deletion of LRRC8A in proximal but not distal tubules and constitutive deletion of LRRC8D cause proximal tubular injury, increased diuresis, and mild Fanconi-like symptoms.

Conclusions
VRAC/LRRC8 channels are crucial for the function and integrity of proximal tubules, but not for more distal nephron segments despite their larger need for volume regulation. LRRC8A/D channels may be required for the basolateral exit of many organic compounds, including cellular metabolites, in proximal tubules. Proximal tubular injury likely results from combined accumulation of several transported molecules in the absence of VRAC channels.
Seizure semiology: ILAE glossary of terms and their significance
Authors: Beniczky Sándor , Tatum William O. , Blumenfeld Hal , Stefan Hermann , Mani Jayanti , Maillard Louis , Fahoum Firas , Vinayan Kollencheri Puthenveettil , Mayor Luis Carlos , Vlachou Maria , Seeck Margitta , Ryvlin Philippe , Kahane Philippe 
Published: July 2022

AbstractThis educational topical review and Task Force report aims to address learning objectives of the International League Against Epilepsy (ILAE) curriculum. We sought to extract detailed features involving semiology from video recordings and interpret semiological signs and symptoms that reflect the likely localization for focal seizures in patients with epilepsy. This glossary was developed by a working group of the ILAE Commission on Diagnostic Methods incorporating the EEG Task Force. This paper identifies commonly used terms to describe seizure semiology, provides definitions, signs and symptoms, and summarizes their clinical value in localizing and lateralizing focal seizures based on consensus in the published literature. Video‐EEG examples are included to illustrate important features of semiology in patients with epilepsy.
Using Sway App as an Instructional Medium for Social Studies Learning in Elementary School
Authors: Merliana Anggit , Aprily Nuraly Masum , Agustini Ani 
Published: July 2022

Tujuan penelitian ini yaitu menghasilkan deskripsi analisis mengenai keefektifan penggunaan aplikasi Sway sebagai media pembelajaran IPS SD pada materi kegiatan Ekspor dan Impor. Penelitian ini menggunakan model penelitian bentuk Reserach and development. Pada penelitian ini dilakukananalisis deskriptif data. Tahap deskriptif digunakan untuk mengungkapkan dan menjelaskan temuan awal penelitian yang berada dilapangan dan dinarasikan dalam bentuk catatan, kemudiam digunakan untuk mengukur tingkat keefektifan dan kepuasan produk tersebut. Hasil penelitian mencakup kepuasan siswa dalam menggunakan aplikasi sway pada materi kegiatan ekspor dan impor yang dilakukan dengan menggunakan sebaran menunjukan 60% efektif dan sangat puas untuk dijadikan sebagai media pembelajaran. Implikasi hasil penelitian ini adalah pengembangan penggunaan media dalam mencapai keefektifan pembelajaran.
TANTANGAN PENGEMBANGAN DESAIN PEMBELAJARAN SEJARAH LOKAL BERBASIS KEHIDUPAN DI MASA PANDEMI COVID 19
Authors: Nafi'ah Ulfatun , Ayundasari Lutfiah , Suprapta Blasius , Sayono Joko , Hasan Zainul 
Published: July 2022

The Covid-19 pandemic hit Indonesia since mid-March 2020 and caused changes to various fields. One of the areas affected is education. Learning activitiess that were originally done face-to-face or directly, are now turning into distance learning or online learning. In the study of history, especially local history, online learning experienced quite complex challenges. This research aims to analyze the problems or challenges experienced by history teachers in East Java in developing life-based history learning designs. This research uses qualitative descriptive methods. The subject of this study is a high school history teacher in East Java. Data collection techniques are carried out using observations, interviews and documentary studies. Data analysis is done by collecting data reduction data, presenting data and verifying the resulting data. As a result, there are obstacles faced by teachers and make learning designs such as doing learning planning, determining, material, choosing media, teaching materials to learning resources. The solution to the challenges faced is to make adjustments to existing conditions by making local history learning designs based online. The initial stage is to analyze basic competencies on the syllabus. The second stage is to determine the indicator of competency achievement (ICA). After the teacher has a ICA, it can determine the material, media, learning resources to learning strategies to create local history learning based on life.
PENGEMBANGAN MODUL DIGITAL TENTANG PERISTIWA G30S/PKI UNTUK MENINGKATKAN MINAT BELAJAR DAN BERPIKIR KRITIS SISWA
Authors: Kusuma Eki Robbi 
Published: July 2022

This study aims to develop teaching materials in the form of modules with the latest media, namely digital books with G30S/PKI materials to increase students' interest in learning and critical thinking skills. This research is a type of R&D research that uses the Borg & Gall development procedure which was modified by Sukmadinata into 3 main stages. The subjects in this development research were students in grade XII at MAN 1 Pasuruan. The instrument for collecting feasibility data was in the form of a questionnaire of material experts, media experts, students, and teachers. The instrument for testing students' interest in learning is using student questionnaires and critical thinking skills using pre-test and post-test. The results of the research on the development of this digital module are as follows. First, the scores of material experts, media experts, teachers, and small and large group tests get a very decent predicate. Second, the testing of students’ interest in the experimental class before and after being given a digital module increased by 25.10 percent. Lastly, the pre-test and post-test of the experimental class increased by an average of 32.59 percent. Penelitian ini bertujuan untuk mengembangkan bahan ajar berupa modul dengan media terkini yakni buku digital dengan materi G30S/PKI untuk meningkatkan minat belajar dan kemampuan berpikir kritis siswa. Penelitian ini merupakan jenis penelitian R&D yang menggunakan prosedur pengembangan Borg & Gall yang dimodifikasi oleh Sukmadinata menjadi tiga tahap utama. Subjek dalam penelitian pengembangan ini adalah siswa kelas XII di MAN 1 Pasuruan. Instrumen pengumpulan data kelayakan berupa angket ahli materi, ahli media, siswa, dan guru. Intrumen pengujian minat belajar siswa menggunakan angket siswa dan kemampuan berpikir kritis menggunakan pre-test dan post-tes. Hasil penelitian pengembangan modul digital ini sebagaimana berikut. Pertama, skor ahli materi, ahli media, guru, uji kelompok kecil dan besar mendapatkan prediket sangat layak. Kedua, Pengujian minat kelas eksperimen sebelum dan sesudah diberikan modul digital meningkat 25.10 persen. Terakhir, pengujian pre-test dan post-test kelas eksperimen meningkat rerata 32.59 percent