bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Pneumococcal Vaccines for Prevention of Invasive Pneumococcal Disease in Adult Patients With Inflammatory Bowel Disease
Authors: Crosby Sheena , Schuh Michael J , Becker Michelle , Ivanov Marina , Caldera Freddy , Farraye Francis A 
Published: July 2022

AbstractPatients with inflammatory bowel disease (IBD) are at a high risk of developing invasive pneumococcal infection both before and after they are diagnosed. The Advisory Committee on Immunization Practices now endorses use of 2 new pneumococcal conjugate vaccines, PCV15 (Vaxneuvance) and PCV20 (Prevnar 20), for patients who have never received a pneumococcal conjugate vaccine or those with unknown vaccination history. Previous studies have shown that pneumococcal vaccination can decrease the risk of developing severe pneumococcal disease; therefore, it is important that patients with IBD receive pneumococcal vaccination. This report aims to inform clinicians who care for patients with IBD about the changes in immunization practices, as it pertains to pneumococcal vaccination and provides appropriate direction on administering vaccination series.
Differing associations with childhood outcomes using behavioural patterns derived from three data reduction techniques
Authors: D’Souza Ninoshka J , Zheng Miaobing , Abbott Gavin , Lioret Sandrine , Hesketh Kylie D 
Published: July 2022

Abstract

Background
Behavioural patterns help to understand the influence of multiple health behaviours on childhood outcomes. Behavioural patterns derived using different data reduction techniques can be non-identical and may differentially associate with childhood outcomes. This study aimed to compare associations of behavioural patterns derived from three methods with three childhood outcomes.

Methods
Data were from the Healthy Active Preschool and Primary Years study when children were 6–8 years old (n = 432). Cluster analysis (CA), latent profile analysis (LPA) and principal component analysis (PCA) were used to derive behavioural patterns from children’s diet, physical activity, sedentary behaviour and sleep data. Behavioural data were obtained through parent report and accelerometry. Children’s height, weight and waist circumference were measured by trained study staff. Health-related quality of life data were obtained using the Pediatric Quality of Life Inventory and academic performance scores were from a national test. Associations between derived patterns from each method and each of the outcomes were tested using linear regression (adjusted for child age and sex and parent education).

Results
Three patterns were each derived using CA and LPA, and four patterns were derived using PCA. Each method identified a healthy, an unhealthy and a mixed (comprising healthy and unhealthy behaviours together) pattern. Differences in associations were observed between pattern groups from CA and LPA and pattern scores from PCA with the three outcomes.

Conclusions
Discrepancies in associations across pattern derivation methods suggests that the choice of method can influence subsequent associations with outcomes. This has implications for comparison across studies that have employed different methods.
Ageism in healthcare technology: the older patients’ aspirations for improved online accessibility
Authors: Zoorob Dani , Hasbini Yasmin , Chen Katherine , Wangia-Anderson Victoria , Moussa Hind , Miller Brian , Brobst Debi 
Published: July 2022

Abstract

Objective
To identify concerns, barriers and facilitators impacting the use of patient portals by older patients as well as desired features in future updates.

Materials and Methods
This is a cross-sectional study consisting of 2 focus group discussions culminating in an anonymous survey administered to women who were 65 years and older receiving urogynecologic care in Northwest Ohio.

Results
Of the 205 women surveyed (91% response rate), providers and healthcare systems play the primary 2 roles (73% and 69%, respectively) in facilitating patients’ use of patient portal systems and telehealth applications. Barriers to use revolved around technical difficulties (50%), privacy concerns (45%), and cost of technology (24%). The most important features desired were the ability to modify the text size within the application (47%) and an intuitive, simple interface (46%). Additional assistance for navigating technical challenges was suggested, specifically set-up of accounts (36%), saving and sharing information with caregivers (35%), and sign-in and navigation of portals (32%).

Conclusion
The paucity of age-aligned medical access software and products may lead to worsening of digital exclusion and disparities in healthcare. Portal application developers and healthcare systems must advance efforts that consider the needs of those who may be older when designing patient portals.
Recent advances in the management of older adults with newly diagnosed multiple myeloma in Japan
Authors: Suzuki Tomotaka , Maruyama Dai , Iida Shinsuke , Nagai Hirokazu 
Published: July 2022

Abstract
Multiple myeloma is a cancer of plasma cells; the incidence rate of multiple myeloma is high among older adults. Although significant advances have been made in the clinical management of multiple myeloma driven by the introduction of novel drugs, such as proteasome inhibitors, immuno- modulators and antibodies, multiple myeloma remains incurable. Hence, the current therapeutic goal for multiple myeloma is to achieve long-term survival while maintaining a good quality of life. In this context, personalized treatment to balance the efficacy and safety of therapies is important, especially for older adults as they display diverse physical, cognitive or organ functioning. Furthermore, old age is also often associated with frailty. Several tools for evaluating frailty in older adults with multiple myeloma are now available, and frail patients defined by these tools have shown a poor prognosis and more treatment-related toxicities. In addition, it is important to evaluate other factors, such as the International Staging System, high-risk chromosomal abnormalities and treatment response, to predict the clinical course of patients. Further investigations are required to determine how these factors can optimize the treatment for multiple myeloma. In this review, we present a detailed account on the developments and issues related to the current treatment approaches for older adults with newly diagnosed multiple myeloma. We also discuss the ongoing phase III clinical study conducted by the lymphoma study group of the Japan Clinical Oncology Group, which targeted older adults with newly diagnosed multiple myeloma.
Arecibo and FAST timing follow-up of 12 millisecond pulsars discovered in Commensal Radio Astronomy FAST Survey
Authors: Miao C C , Zhu W W , Li D , Freire P C C , Niu J R , Wang P , Yuan J P , Xue M Y , Cameron A D , Champion D J , Cruces M , Chen Y T , Chi M M , Cheng X F , Dang S J , Ding M F , Feng Y , Gan Z Y , Hobbs G , Kramer M , Liu Z J , Li Y X , Luo Z K , Miao X L , Meng L Q , Niu C H , Pan Z C , Qian L , Sun Z Y , Wang N , Wang S Q , Wang J B , Wu Q D , Wang Y B , Wang C J , Wang H F , Wang S , Xie X Y , Xie M , Xiao Y F , Yuan M , Yue Y L , Yao J M , Yan W M , You S P , Yu X H , Zhao D , Zhao R S , Zhang L 
Published: July 2022

ABSTRACT
We report the phase-connected timing ephemeris, polarization pulse profiles, Faraday rotation measurements, and Rotating-Vector-Model (RVM) fitting results of 12 millisecond pulsars (MSPs) discovered with the Five-hundred-meter Aperture Spherical radio Telescope (FAST) in the Commensal Radio Astronomy FAST survey (CRAFTS). The timing campaigns were carried out with FAST and Arecibo over 3 yr. 11 of the 12 pulsars are in neutron star–white dwarf binary systems, with orbital periods between 2.4 and 100 d. 10 of them have spin periods, companion masses, and orbital eccentricities that are consistent with the theoretical expectations for MSP–Helium white dwarf (He WD) systems. The last binary pulsar (PSR J1912−0952) has a significantly smaller spin frequency and a smaller companion mass, the latter could be caused by a low orbital inclination for the system. Its orbital period of 29 d is well within the range of orbital periods where some MSP–He WD systems have shown anomalous eccentricities, however, the eccentricity of PSR J1912−0952 is typical of what one finds for the remaining MSP–He WD systems.
Galactic seismology: joint evolution of impact-triggered stellar and gaseous disc corrugations
Authors: Tepper-García Thor , Bland-Hawthorn Joss , Freeman Ken 
Published: July 2022

ABSTRACT
Evidence for wave-like corrugations are well established in the Milky Way and in nearby disc galaxies. These were originally detected as a displacement of the interstellar medium about the mid-plane, either in terms of vertical distance or vertical velocity. Over the past decade, similar patterns have emerged in the Milky Way’s stellar disc. We investigate how these vertical waves are triggered by a passing satellite. Using high-resolution N-body/hydrodynamical simulations, we systematically study how the corrugations set up and evolve jointly in the stellar and gaseous discs. We find that the gas corrugations follow the stellar corrugations, i.e. they are initially in phase although, after a few rotation periods (500–700 Myr), the distinct waves separate and thereafter evolve in different ways. The spatial and kinematic amplitudes (and thus the energy) of the corrugations dampen with time, with the gaseous corrugation settling at a faster rate (∼800 Myr versus ∼1 Gyr). In contrast, the vertical energy of individual disc stars is fairly constant throughout the galaxy’s evolution. This difference arises because corrugations are an emergent phenomenon supported by the collective, ordered motions of co-spatial ensembles of stars. We show that the damping of the stellar corrugations can be understood as a consequence of incomplete phase mixing, while the damping of the gaseous corrugations is a natural consequence of the dissipative nature of the gas. We suggest that – in the absence of further, strong perturbations – the degree of correlation between the stellar and gaseous waves may help to age-date the phenomenon.
A stochastic model to reproduce the star formation history of individual galaxies in hydrodynamic simulations
Authors: Wang Yang , Napolitano Nicola R , Cui Weiguang , Li Xiao-Dong , Knebe Alexander , Power Chris , Pearce Frazer , Tang Lin , Yepes Gustavo , Kang Xi 
Published: July 2022

ABSTRACT
The star formation history (SFH) of galaxies is critical for understanding galaxy evolution. Hydrodynamical simulations enable us to precisely reconstruct the SFH of galaxies and establish a link to the underlying physical processes. In this work, we present a model to describe individual galaxies’ SFHs from three simulations: TheThreeHundred, Illustris-1, and TNG100-1. This model divides the galaxy SFH into two distinct components: the ‘main sequence’ and the ‘variation’. The ‘main sequence’ part is generated by tracing the history of the SFR − M* main sequence of galaxies across time. The ‘variation’ part consists of the scatter around the main sequence, which is reproduced by fractional Brownian motions. We find that: (1) the evolution of the main sequence varies between simulations; (2) fractional Brownian motions can reproduce many features of SFHs; however, discrepancies still exist; and (3) the variations and mass-loss rate are crucial for reconstructing the SFHs of the simulations. This model provides a fair description of the SFHs in simulations. On the other hand, by correlating the fractional Brownian motion model to simulation data, we provide a ’standard’ against which to compare simulations.
Implications of the cosmological 21-cm absorption profile for high-redshift star formation and deep JWST surveys
Authors: Mittal Shikhar , Kulkarni Girish 
Published: July 2022

ABSTRACT
Apart from its anomalously large depth, the cosmological 21-cm absorption signal measured by the EDGES collaboration also has a shape that is distinctly different from theoretical predictions. Models with non-traditional components such as super-adiabatic baryonic cooling or an excess radio background (ERB) explain the depth of the observed profile, but still conspicuously fail to explain its shape. In this paper, we quantify the requirements imposed by the EDGES measurement on sources of Ly α and X-ray photons in the presence of ERB at cosmic dawn. In extreme cases, the Ly α and X-ray emissivities require to be enhanced by up to an order of magnitude relative to traditional models. Furthermore, this enhancement needs to be active only for a short duration. We find that under conventional assumptions for the cosmic star formation rate density (SFRD), standard stellar populations are incapable of meeting these conditions. Only highly unusual models of massive metal-free stars seem to provide a possible mechanism. Conversely, if the sources of Ly α and X-ray photons are compelled to have standard properties, the EDGES measurement puts strong demands on the cosmic SFRD. This provides interesting falsifiable predictions for high-redshift galaxy surveys enabled by the James Webb Space Telescope (JWST). We derive predictions for galaxy UV luminosity functions and number densities, and show that a deep JWST survey with a limiting UV magnitude of mUV, lim = 32 would potentially be able to rule out the predictions enforced by the EDGES measurement.
Unmasking the mammalian SET domain-containing protein 4
Authors: Wang Yuan , Shen Zhiyuan 
Published: July 2022

Abstract
SET domain-containing protein 4 (SETD4) is a member of a unique class of protein lysine methyltransferases. Here, we introduce the basic features of SETD4 and summarize the key findings from recent studies with emphases on its roles in tissue development and tumorigenesis, and its methylation substrates. SETD4 is expressed in stem/progenitor cells. Ablation of Setd4+ cells impedes the repopulation of acinar cells after pancreatic injury. Setd4 deletion in mice promotes the recovery of radiation-induced bone marrow (BM) failure by boosting the function of BM niche, facilitates the generation of endothelial cells and neovascularization of capillary vessels in the heart, enhances the proliferation of BM mesenchymal stem cells and disrupts the TLR4 signaling in BM-derived macrophages. SETD4 expression is also associated with the maintenance of quiescent breast cancer stem cells. While mouse Setd4 knockout delays radiation-induced T-lymphoma formation, elevated SETD4 expression has been observed in some proliferative cancer cells and is associated with a pro-survival potential. Oncogenic fusions of SETD4 have also been identified in cancer, albeit rare. In addition, SETD4 methylates lysine-570 in the C-terminal globular domain of KU70, which enables KU70 translocation to cytoplasm to suppress apoptosis.
Quantification of mutant–allele expression at isoform level in cancer from RNA-seq data
Authors: Deng Wenjiang , Mou Tian , Pawitan Yudi , Vu Trung Nghia 
Published: July 2022

AbstractEven though the role of DNA mutations in cancer is well recognized, current quantification of the RNA expression, performed either at gene or isoform level, typically ignores the mutation status. Standard methods for estimating allele-specific expression (ASE) consider gene-level expression, but the functional impact of a mutation is best assessed at isoform level. Hence our goal is to quantify the mutant–allele expression at isoform level. We have developed and implemented a method, named MAX, for quantifying mutant–allele expression given a list of mutations. For a gene of interest, a mutant reference is constructed by incorporating all possible mutant versions of the wild-type isoforms in the transcriptome annotation. The mutant reference is then used for the RNA-seq reads mapping, which in principle works similarly for any quantification tool. We apply an alternating EM algorithm to the read-count data from the mapping step. In a simulation study, MAX performs well against standard isoform-quantification methods. Also, MAX achieves higher accuracy than conventional gene-based ASE methods such as ASEP. An analysis of a real dataset of acute myeloid leukemia reveals a subgroup of NPM1-mutated patients responding well to a kinase inhibitor. Our findings indicate that quantification of mutant–allele expression at isoform level is feasible and has potential added values for assessing the functional impact of DNA mutations in cancers.
Screening recommendation adherence among first-degree relatives of individuals with colorectal cancer
Authors: Fiala Mark A 
Published: July 2022

Abstract
A first-degree relative (FDR) with colorectal cancer (CRC) is one of the most important risk factors for the disease. Adherence to CRC screening recommendations can help mitigate this risk; however, adherence has historically been low. This study aimed to determine the factors associated with CRC screening. The study used data from the 2015 National Health Interview Survey. CRC screening rates were compared between FDRs and their peers without a family history of CRC. Participants were considered to be adherent if they had undergone any of the following: fecal immunochemical test within the prior 1 year, sigmoidscopy or computed tomography colongraphy within 5 years, or colonoscopy within 10 years. The analysis included 11,381 participants age 50–75 at time of survey. Overall, 62% of participants were adherent to screening recommendations. Seventy-six percent of FDRs of individuals with CRC were adherent to guidelines; they were 86% more likely to be adherent than their peers. Race, ethnicity, and socioeconomic variables were all associated with adherence. Models were largely similar between FDRs of individuals with CRC and the general public. Nearly one-quarter of FDRs of individuals with CRC are not adherent to screening recommendations. Further outreach is needed for members of minority races and the Hispanic community and additional efforts are needed to increase the accessibility of CRC screening for those with more limited finances and the uninsured.
Childcare and Mothers’ Labor Market Outcomes in Lower- and Middle-Income Countries
Authors: Halim Daniel , Perova Elizaveta , Reynolds Sarah 
Published: July 2022

AbstractImproving women's labor force participation and the quality of their employment can boost economic growth and support poverty and inequality reduction; thus, it is highly pertinent for the development agenda. However, existing systematic reviews on female labor market outcomes and childcare, which can arguably improve these outcomes, are focused on developed countries. We review 22 studies which plausibly identify the causal impact of institutional childcare on maternal labor market outcomes in lower-and-middle income countries. All but one study finds positive impacts on the extensive or intensive margin of maternal labor market outcomes, which aligns with findings from developed countries. We further analyze aspects of childcare design, including hours, ages of children, coordination with other childcare services that may increase the impacts on maternal labor market outcomes. We conclude with a discussion of directions for future research.
CHCHD2 maintains mitochondrial contact site and cristae organizing system stability and protects against mitochondrial dysfunction in an experimental model of Parkinson's disease
Authors: Lu Lin , Mao Hengxu , Zhou Miaomiao , Lin Yuwan , Dai Wei , Qiu Jiewen , Xiao Yousheng , Mo Mingshu , Zhu Xiaoqin , Wu Zhuohua , Pei Zhong , Guo Wenyuan , Xu Pingyi , Chen Xiang 
Published: July 2022

Background:
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's dementia. Mitochondrial dysfunction is involved in the pathology of PD. Coiled-coil-helix-coiled-coil-helix domain-containing 2 (CHCHD2) was identified as associated with autosomal dominant PD. However, the mechanism of CHCHD2 in PD remains unclear.

Methods:
Short hairpin RNA (ShRNA)-mediated CHCHD2 knockdown or lentivirus-mediated CHCHD2 overexpression was performed to investigate the impact of CHCHD2 on mitochondrial morphology and function in neuronal tumor cell lines represented with human neuroblastoma (SHSY5Y) and HeLa cells. Blue-native polyacrylamide gel electrophoresis (PAGE) and two-dimensional sodium dodecyl sulfate-PAGE analysis were used to illustrate the role of CHCHD2 in mitochondrial contact site and cristae organizing system (MICOS). Co-immunoprecipitation and immunoblotting were used to address the interaction between CHCHD2 and Mic10. Serotype injection of adeno-associated vector-mediated CHCHD2 and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration were used to examine the influence of CHCHD2 in vivo.

Results:
We found that the overexpression of CHCHD2 can protect against methyl-4-phenylpyridinium (MPP+)-induced mitochondrial dysfunction and inhibit the loss of dopaminergic neurons in the MPTP-induced mouse model. Furthermore, we identified that CHCHD2 interacted with Mic10, and overexpression of CHCHD2 can protect against MPP+-induced MICOS impairment, while knockdown of CHCHD2 impaired the stability of MICOS.

Conclusion:
This study indicated that CHCHD2 could interact with Mic10 and maintain the stability of the MICOS complex, which contributes to protecting mitochondrial function in PD.
Percutaneous local tumor ablation vs. stereotactic body radiotherapy for early-stage non-small cell lung cancer: a systematic review and meta-analysis
Authors: Chen Dongjie , Zhao Man , Xiang Xiaoyong , Liang Jun 
Published: July 2022

Abstract

Background:
Percutaneous local tumor ablation (LTA) and stereotactic body radiotherapy (SBRT) have been regarded as viable treatments for early-stage lung cancer patients. The purpose of this study was to compare the efficacy and safety of LTA with SBRT for early-stage non-small cell lung cancer (NSCLC).

Methods:
PubMed, Embase, Cochrane library, Ovid, Google scholar, CNKI, and CBMdisc were searched to identify potential eligible studies comparing the efficacy and safety of LTA with SBRT for early-stage NSCLC published between January 1, 1991, and May 31, 2021. Hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were applied to estimate the effect size for overall survival (OS), progression-free survival (PFS), locoregional progression (LP), and adverse events.

Results:
Five studies with 22,231 patients were enrolled, including 1443 patients in the LTA group and 20,788 patients in the SBRT group. The results showed that SBRT was not superior to LTA for OS (HR = 1.03, 95% CI: 0.87–1.22, P = 0.71). Similar results were observed for PFS (HR = 1.09, 95% CI: 0.71–1.67, P = 0.71) and LP (HR = 0.66, 95% CI: 0.25–1.77, P = 0.70). Subgroup analysis showed that the pooled HR for OS favored SBRT in patients with tumors sized >2 cm (HR = 1.32, 95% CI: 1.14–1.53, P = 0.0003), whereas there was no significant difference in patients with tumors sized ≤2 cm (HR = 0.93, 95% CI: 0.64–1.35, P = 0.70). Moreover, no significant differences were observed for the incidence of severe adverse events (≥grade 3) (OR = 1.95, 95% CI: 0.63–6.07, P = 0.25) between the LTA group and SBRT group.

Conclusions:
Compared with SBRT, LTA appears to have similar OS, PFS, and LP. However, for tumors >2 cm, SBRT is superior to LTA in OS. Prospective randomized controlled trials are required to determine such findings.

INPLASY Registration Number:
INPLASY202160099