bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potensi Kurkumin Kombinasi Silibinin (Cur-Sil)-Loaded Nanopartikel Magnetik (Fe3O4) Termodifikasi [Poly(Ethyelene Caprolactone)-Poly(Ethyelene Glycol) (PCL-PEG)] Ko-polimer sebagai Inhibitor Gen Leptin dalam Tata Laksana Kanker Paru
Authors: Wisnawa Ayu Dilia Febriani 
Published: February 2022

<p><strong>Pendahuluan: </strong>Kanker paru merupakan kanker dengan insiden paling tinggi dan menyebabkan mortalitas yang signifikan pada pria. Leptin, sitokin derivat adiposit, memainkan peran penting pada proses karsinogenesis kanker paru. Kurkumin dan silibinin adalah komponen herbal alami dengan karakteristik antikanker bersifat multitarget. <strong>Diskusi: </strong>Teknologi nanopartikel magnetik (<em>Fe<sub>3</sub>O<sub>4</sub></em>) memiliki sifat super-paramagnetik yang unik, sehingga meningkatkan kemampuan untuk mencapai target spesifik. Nanopartikel magnetik dilapisi dengan kopolimer <em>polyethylene-caprolactone-polyethylene glycol</em> (PCL-PEG) untuk meningkatkan stabilitas dan mengeliminasi kemungkinan agregasi permukaan substansi kurkumin dan silibinin yang dilapisi nanopartikel. Subtansi kurkumin dan silibinin dalam nanopartikel magnetik (Fe<sub>3</sub>O<sub>4</sub>) berbasis PCL-PEG termodifikasi digunakan sebagai inhibitor ekspresi leptin. <strong>Simpulan: </strong>Tinjauan pustaka menunjukkan berbagai manfaat farmakologi kurkumin dan silibinin ter-enkapsulasi nanopartikel magnetik berbasis kopolimer PCL-PEG termodifikasi sebagai inhibitor ekspresi leptin yang efektif tanpa toksisitas pada jaringan normal. Penemuan ini dapat digunakan sebagai alternatif tata laksana kanker paru di Indonesia.</p><p><em></em><br /><em><br /></em><strong>Introduction: </strong>Lung cancer is the highest incidence of cancer and causes significant mortality in male. Leptin, an adipocyte derivative cytokine, plays a role in carcinogenesis in lung cancer. Curcumin (CUR) and silibinin (SIL) are natural herbal compounds with multitargeted anticancer properties. <strong>Discussion: </strong>Magnetic nanoparticle (Fe<sub>3</sub>O<sub>4</sub>) technology has unique super-paramagnetic properties, increasing the ability to reach specific targets. Magnetic nanoparticles are coated with polyethylene-caprolactone-polyethylene glycol (PCL-PEG) copolymers to improve stability and to eliminate the possibility of surface aggregation of nanoparticles-load curcumin and silibinin substances. The modified PCL-PEG-based magnetic nanoparticles (Fe<sub>3</sub>O<sub>4</sub>) of curcumin and silibinin are used as inhibitors of leptin expression. <strong>Conclusion: </strong>Literature studies reveal various pharmacological advantages of curcumin and silibinin encapsulated with modified PCL-PEG copolymers magnetic nanoparticles as effective inhibitors in leptin expression without toxicity in normal tissue. It can be used as an alternative in lung cancer management in Indonesia.<br /> <br /> </p>
CONSTRUÇÃO DE SABERES SOBRE O CORPO. O FAZER FALAR DE UM SABER MÉDICO
Authors: Azambuja Renato , Souza Nadia Geisa Silveira de 
Published: February 2022

RESUMO
Verdades médicas são entendidas como saberes constituídos historicamente em suas complexidades e heterogeneidades que as constituíram. Para a biomedicina, as práticas discursivas tendem a levar efeitos em que os indivíduos se subjetivam enquanto corpos estruturados em órgãos, independente do contexto onde se processam as relações do seu viver. Trazemos uma visão que integra mente e corpo na compreensão da enfermidade, a partir de um saber médico historicamente sujeitado, a Homeopatia, sobre os processos de adoecimento e pela possibilidade de uma prática em saúde transformadora de si.
A DESCRENÇA COMO TERAPIA. O PROCEDIMENTO CÉTICO FRENTE À PERTUBAÇÃO DOGMÁTICA
Authors: Junnior Neto Francisco Alvarenga 
Published: February 2022

A intenção deste artigo é apresentar o percurso realizado pelo indivíduo que se compreende como cético. O ceticismo é visto como contrário à posição dogmática, marcada pela defesa de argumentos e teses como verdades. Apesar de assim se definir o ceticismo: como uma postura marcada pela descrença, o ceticismo não pode ser compreendido somente por isto; ou seja, pensando o indivíduo cético, ele não é visto como tal pela sua vontade de contrapor teses pelo puro gosto de realizá-lo, antes disso, a descrença e a oposição levadas a cabo pelo cético são quase que naturais, como resultados inescapáveis da sua forma de proceder. Para tanto, compreender o processo que leva alguém a se tornar um cético e se posicionar contra o dogmatismo, na primeira seção buscaremos apresentar o ceticismo filosófico. Na segunda seção, se intentará apresentar o itinerário cético por meio do qual se estabelece a sua identidade. Na última seção, buscaremos salientar quais são os pontos do dogmatismo atacados pelo cético a fim de demonstrar a sua impossibilidade enquanto uma posição filosófica.
O REDIMENSIONAMENTO DAS VULNERABILIDADES NO ÂMBITO DA RELAÇÃO MÉDICO-PACIENTE DIANTE DA COVID-19 NO CONTEXTO PANDÊMICO BRASILEIRO
Authors: Araujo Ana Thereza Meirelles , Lins-Kusterer Liliane 
Published: February 2022

Artigo destinado a refletir sobre a conformação do panorama de vulnerabilidades no âmbito da relação médico-paciente, a partir do cenário instaurado pela pandemia do COVID-19. Buscou-se avaliar a mudança paradigmática de atuação do Direito e da Medicina em face das demandas decorrentes do contexto pandêmico, considerando o atual estado de conhecimento científico da doença. Foram aportadas as noções conceituais e tipológicas da ideia de vulnerabilidade, considerando suas dimensões ontológica ou universal e circunstanciais ou secundárias. No âmbito da saúde, buscou-se identificar o acréscimo e a potencialização de vulnerabilidades às partes dentro da relação médico-paciente a partir das diversas situações relacionadas à pandemia.
Palavras-chave: vulnerabilidade na relação médico-paciente; bioética e direito; pandemia.
Plans, Takes, and Mis-takes
Authors: Klemp Nathaniel , McDermott Ray , Raley Jason , Thibeault Matthew , Powell Kimberly , Levitin Daniel J. 
Published: February 2022

This paper analyzes what may have been a mistake bypianist Thelonious Monk playing a jazz solo in 1958.Even in a Monk composition designed for patternedmayhem, a note can sound out of pattern. We reframethe question of whether the note was a mistake and askinstead about how Monk handles the problem. Amazingly,he replays the note into a new pattern that resituatesits jarring effect in retrospect. The mistake, orbetter, the mis-take, was “saved” by subsequent notes.Our analysis, supported by reflections from jazz musiciansand the philosopher John Dewey, encourages areformulation of plans, takes, and mis-takes as categoriesfor the interpretation of contingency, surprise, andrepair in all human activities. A final section suggeststhat mistakes are essential to the practical plying andplaying of knowledge into performances, particularlythose that highlight learning.
L’amélioration des compétences scolaires des enfants de migrants en Suisse : l’encouragement comme nouveau paradigme des politiques éducatives
Authors: Mottet Geneviève 
Published: February 2022

Cet article s’intéresse à la manière dont les politiques suisses se sont déployées depuis les années 2000 pour promouvoir l’amélioration des compétences scolaires des enfants de migrants. L’encouragement apparaît comme un nouveau paradigme de la lutte contre la désaffiliation scolaire et sociale des publics dont les caractéristiques sont appréhendées à partir de la notion de « cumul du handicap social et ethnique ». Nous verrons tout d’abord que ce mode de désignation et de reconnaissance des publics « à risque » s’opérationnalise par le développement de mesures ciblant les territoires au fort taux de pauvreté et visant à l’augmentation des compétences des jeunes y vivant dans des conditions d’apprentissage défavorables. L’article montrera ensuite comment dans cette visée de lutte contre les risques de chômage et d’assistance des populations qui vivent dans ces territoires, l’accompagnement des publics « à risque » s’est opéré par l’institutionnalisation de dispositifs encourageant leur prise en charge précoce (préscolarisation), par les institutions de l’État ainsi que, parallèlement, par l’encouragement des carrières exemplaires des migrants « à potentiels ». Il révèle les enjeux sous-jacents aux mots d’ordre promus unilatéralement.
Comparative Evaluation of Microleakage in Premolars after Placement of Microhybrid and Nanohybrid Composite Using Snow Plow Technique
Authors: Dugar Meghna , Ikhar Anuja 
Published: February 2022

Background: Microleakage is the significant reason for composite restoration failure. The type of composite material utilized should reduce polymerization shrinkage and hence avoid micro-leakage.
Objectives:

To evaluate microleakage in Class I cavity using microhybrid composite in snow plow placement technique.
To evaluate microleakage in Class I cavity using nanohybrid composite in snow plow placement technique
To compare microleakage in Class I cavity with microhybrid composite and nanohybrid composite using snow plow placement technique.

Methodology: Prepared Class I cavities in 22 human premolars will be divided randomly into 2 groups based on the restorative material used. These cavity preparations will be restored using the snow plow technique. All the specimens will be thermocycled and stained with 50% silver nitrate solution. We will wash the specimens in the distilled water, store them in the developing solution and for 24 hours exposed to sunlight. The samples will be sectioned longitudinally from the middle of cavity into two parts and will be then evaluated for microleakage on the basis of silver nitrate penetration under stereomicroscope (20X). To compare the microleakage, data will be subjected to statistical analysis.
Expected Results: Nanohybrid composite placement using snow plow technique is expected to have less micro-leakage than microhybrid composite placement using the same technique.
Conclusion: If this study proves correct, this would be helpful for the clinicians to choose the most efficient restorative material with the best technique and minimal microleakage which will aid in the success of the root canal treatment.
Role of Herbals as Immunity Boosters in the Management of COVID-19
Authors: Shivani . , Puri Ritika 
Published: February 2022

The review mainly focuses on various herbs that can be used for the enhancement of immunity amidst COVID-19 pandemic. Coronavirus comes under the viruses that are capable of causing common cold, raising the temperatures and also can result in severe acute respiratory syndrome. The major threat to public health is caused due to the emerging infections such as SARS.
Novel Coronavirus or COVID-19 has spread across various countries and been declared as a ‘pandemic’ by the World Health Organization. Basically, coronavirus affects the individuals which have low immunity. However, one can adopt various herbs that can increase the amount of intestinal beneficial bacteria and can make up 85% of the immune system of the body. So, making use of such herbs one can very effectively promote health and boost immunity to fight against the virus attack. Also, the plants based play a major role in boosting the immunity and preventing the individuals from catching COVID-19 infections.
Comparative Study of Efficacy of Jatamansi (Nardostachys jatamansi DC) and Imipramine in Generalized Anxiety Disorder (G.A.D.): A Randomized Controlled Double Blind Clinical Trial
Authors: Sheetal Thosar , Swanand Pathak , Nilima Wadnerwar , Mohan Yende , Rajkumar Gupta 
Published: February 2022

Background: Onset of G.A.D. is related with bigger excessiveness and uncontrolled worry, along with more chronic course and more severe life mutilation.Individuals suffering from G.A.D. are at high risk of bothered mental health, social functioning, and overall physical &mental well being. Limited long-term efficacy of anxiolytic drugs has shown by clinical trials but drowsiness, dependency, impaired cognition and memory and sexual dysfunction like loss of libido are common adverse side effects of these drugs. Nardostachys jatamansi is a reputed Ayurvedic herb useful for treatment of various disorders mainly central nervous disorders. Various preclinical and clinical studies had proven anxiolytic activity of Jatamansi. Hence present study is planned to assess effects of Jatamansiin Generalized Anxiety Disorder.
Materials and Methods: Presentdouble-blind randomized control clinical study involves two groups with 38 subjects each. Group A (Study Group) will be treated with administration of Tab. Jatamansi in the dose of 1000 mg B.D. orally with water. Group B (Control Group)will betreated with administration of Tab. Imipramine 75 mg H.S. orallyfor 60 days. Assessment parameter will be anxiety score based on symptoms of Generalized Anxiety Disorder. H.A.M.-A. Scale, G.A.D. – 7 Scale, Manas Bhava and Oxidative Stress. Primary outcome of study is improvement in the sign and symptoms of anxiety with reduction in anxiety scale score.
Evaluation of Vamana and Virechana Karma in the Treatment of Hypothyroidism – A Study Protocol
Authors: Mehta Ashish , Parwe Shweta 
Published: February 2022

Background: Hypothyroidism can be understood and assessed on the basis of Agni, Doshas, Dushyas, Sthanas and Srotasas. In Ayurveda Vamana and Virechana Karma is considering as best line of Shodana procedures for the removal of toxin materials from the human body. Hypothyroidism occurs because of hypo functioning of thyroid gland which is located in neck region and even most of the signs and symptoms prove the involvement of Kapha Sthana and Kapha Dosha. So, in the present clinical research, Vamana and Virechana karma of Panchkarama will be selected as clinical tool to check its impact on Hypothyroidism (Galaganda).
Aim and Objectives: To explore Vamana & Virechana Karma regarding their Clinical Importance. To validate Vamana & Virechana Karma as an effective mode of treatment in the management of Hypothyroidism.
Methodology: 90 (45 in each group) patients will be selected by randomized reference standard controlled single blind double arm clinical trial, and third party will assign and enlist the patient. In Group A (Control) – Standard/ Control Group treated with Thyroxin and Group B (Experimental) – Intervention Group treated with Vamana and Virechana Karma. The evaluation will be recorded on 0 30, 60, 90, 120, 150, 180 days.
Results: Changes will be observed in objective outcomes.
Conclusion: Vamana and Virechana will be effective in Hypothyroidism.
Comparative Efficacy of Osteotome vs CAS Kit Assisted Indirect Maxillary Sinus Lift and Immediate Implant Placement in Posterior Atrophic Maxilla – A Study Protocol
Authors: Shende Himanshu , Mundada Bhushan , Bhola Nitin 
Published: February 2022

Background: In today’s era implants are mostly used for replacing missing teeth. The greatest challenge for placing an implant is posterior maxillary teeth where the problems arise due to presence of maxillary sinus due which increases the risk of perforating the sinus membrane while implanting. In literature there are many techniques to overcome these problems and place the implant without perforating the sinus membrane. The current study is conducted to check either the traditional technique osteotome or modern technique CAS-Kit is better for placing an implant in posterior maxillary region.
Objectives: The aim of these study is to compare and evaluate clinical and radiological outcomes of conventional osteotome technique and CAS kit use for indirect sinus lifting in atrophic posterior maxilla.
Methodology: Two groups (study & control) with 20 individuals requiring implant prosthesis in atrophic posterior maxillary region with RBH < 3mm and minimum crestal width of 6mm are considered for the study model. After completion of osteotome and sinus lift procedure, integrity of sinus membrane will be checked by Valsalva manoeuvre. At three months after implant placement a second step surgery will be performed, stability of each implant will be checked. Marginal bone loss and amount of bone generation will be checked on Cone-beam computed tomography systems (CBCT) at 3, 6 & 9 month interval.
Expected Results: CAS kit is relatively newer and advanced equipment which is safer in placing implant in posterior atrophic maxilla without perforating sinus membrane with good amount of bone generation and stability of implant. with minimal marginal bone loss.
Conclusion: Placement of an implant with CAS-Kit is better option than performing osteotome procedure which is time consumable with high chance of membrane perforation and large amount of marginal bone loss.
Adherence of Insulin Therapy in Diabetic Mellitus Patients in a Tertiary Care Hospital
Authors: Ahalya R. , Kumar Mahendra 
Published: February 2022

Aim and Objective: The aim of this study is to evaluate the adherence of Insulin therapy in Diabetic mellitus patients and to identify the factors leading to poor adherence of Insulin therapy among diabetic patients in a tertiary care hospital.
Methodology: A prospective study was carried out in the department of medicine in Saveetha medical college from January to June 2021.
50 diabetic patients were included in the study and their adherence to Insulin therapy was monitored and the patients with low adherence were assessed for the cause so that appropriate interventions can be taken to improve its adherence.
Results: The study enrolled about 50 patients out of which 23 of them had low Insulin adherence. The main reasons for low adherence were expense of Insulin(40%),lack of knowledge of administration(36%), and others factors include family problems, having faith over alternative medicines and fear of side effects.
Conclusion: Given the great prevalence of primary non-adherence and the variety of reasons for it, it is evident that these treatment barriers must be removed. Dedicated diabetes instructors at each diabetes clinic, as well as the availability of low-cost insulin and blood glucose monitoring devices for the disadvantaged, are essential to achieving this goal.
A Clinicopathological Study of Malignant Peripheral Nerve Sheath Tumors- At a Tertiary Care Center
Authors: Edwin Danita G. S. , Akaash R. Lalith , Sekhar Ganthimathy 
Published: February 2022

Aim: To study the clinicopathological profile in Malignant Peripheral Nerve Sheath Tumors (MPNST).
Study Design: A retrospective descriptive study.
Place and Duration of Study: Department of Pathology, Saveetha medical college and hospital, Chennai, between June 2016 and May 2021.
Methodology: A complete enumerative sampling of all the MPNSTs received at Saveetha Medical College and Hospital over a five-year period was done which included 9 cases (4 men, 5women; age range (19-66 years). The details were obtained from the records in the Department of Pathology. The demographic parameters, clinical and histomorphological data were tabulated and analysed.
Results: Nine cases of MPNSTs were received in our hospital during the study period. In our study a female preponderance was noted, with late thirties being the median age of presentation. Extremities and trunk were the most common sites. Two rare lesions involving the pancreas and mesentery were reported. 4 cases had underlying Neurofibromatosis (NF1). The average tumour size was 8.8cm, with majority having a tumour size >5cm. Histomorphologically most cases showed hypo and hypercellular areas composed of spindle cells with wavy nuclei arranged in interlacing fascicles with increased mitotic activity and tumour necrosis. Two cases showed epithelioid differentiation and three had heterologous elements in the form of glandular differentiation or rhabdomyoblastic differentiation.
Conclusion: MPNSTs are very rare tumours accounting for 6% of soft tissue sarcomas and have a very aggressive course. Details of the clinical presentation and careful histomorphological typing of these tumours are essential for identifying and treating them.
Holistic Approach via Physiotherapeutic Intervention in a Complex Multiple Fracture Hampering a Middle-Class Man’s Life- a Case Report
Authors: Boob Manali , Lakhwani Madhu , Phansopkar Pratik 
Published: February 2022

Ankle fractures contribute to almost nine percent of all fractures of the weight-bearing joints, with uni, bi, and trimalleolar fractures being the most prevalent. Weber’s and (AO/ASIF) classifications are commonly used for easy analysis. Tibial plateau fractures can range in severity from stable to severely comminuted unstable fractures with extensive tissue injury, putting the extremities' at risk, according to the Schatzker grading system. The ulna is a long bone in the forearm that extends parallel to the radius and travels medially. The severity of proximal ulna fractures ranges from basic AO/OTA Classification fractures to severe Monteggia fractures or Monteggia-like lesions. After a road accident, a 35-year-old man with compound grade 3B ankle dislocation, Schatzker type 1 fracture of tibia, and proximal 1/3 ulnar shaft fracture of the left side were diagnosed on x-ray with external application of a delta fixator over the ankle, open reduction and internal fixation on the tibial plateau with screws and the nail was impacted over the ulna fracture. After the procedure, the patient was treated with physical therapy for 12 weeks, beginning with static regimens and proceeding to dynamic exercises, electrotherapeutic modalities, strengthening exercises, and gait exercises. The purpose of this study was to explore potential favorable rehabilitation effects in the use of exercises following operatively treated unstable ankle fractures requiring partial weight-bearing in the first six postoperative weeks.
Conclusion: It could be shown that Immediate Postoperative Physical Therapy protocol in a proper scheduled manner helped the Patient to return to his daily activities with improved ranges, strength, and motivation to work again without any difficulties.
Study of Placental Chorangiosis in a Tertiary Care Centre
Authors: Vanishree M. , Sulochana Sonti , Salin Martin M. S. 
Published: February 2022

Background: Chorangiosis is a condition in which the number of vascular channels in the noninfarcted, nonischemic areas of the placenta increases dramatically. Chorangiosis rarely occurs in normal pregnancies.
Aims: To study the demography, maternal and fetal causes of chorangiosis.
Study Design: A retrospective descriptive study.
Place and Duration of Study: Total of 73 patients with chorangiosis were studied in Department of Pathology Saveetha Medical College,during the period ofAugust 2020 and February 2021.
Methodology: Study included 73 patients of placental chorangiosis.The clinical history and demographic data was obtained from the patient’s medical records.Thematernal and fetal causes were studied, and clinico-histopathological correlation was done.
Results: This study includes 73 postnatal women,of whichthe rate of cesarean section was noted to be 69.8% and the mean value were obtained showed mean gestational age of 37.5 weeks, 70 live births and 3 neonatal deaths; mean placental weight is 480 grams and birth weight 3970grams.The mean 1 minute and 5 minutes APGAR score is reduced indicatingdisturbance in fetal vitals immediately after birth.
Conclusion: Chorangiosis is a rare illness, which is associated with an increased risk of prenatal and neonatal morbidity and mortality.So, it should be regarded as a key prognostic indicator of poor pregnancy outcomes and should be essentially reported in the histopathological evaluation.