bluuebunny/crossref_metadata_2025_split huggingface dataset:
Origin of the Palos Verdes Restraining Bend and Its Implications for the 3D Geometry of the Fault and Earthquake Hazards in Los Angeles, California
Authors: Wolfe Franklin D. , Shaw John H. , Plesch Andreas 
Published: July 2022

ABSTRACT
The Palos Verdes fault zone (PVFZ) extends across the southwestern Los Angeles basin and Inner Continental Borderland, California, and is considered capable of generating large (Mw&gt;7), damaging earthquakes with short recurrence intervals. The 110 km long fault zone is composed of vertical and moderately dipping segments that accommodate oblique, right-lateral reverse displacement. Onshore, there is a counterclockwise reorientation in the PVFZ’s strike, which produces a major restraining bend that generates the Palos Verdes Peninsula. Here, we use well and seismic reflection data to develop kinematic models that show folding of the PVFZ by the Wilmington blind thrust led to formation of the restraining bend. North of the peninsula in Santa Monica Bay, debate persists over the extent, geometry, and activity of the PVFZ. Here, we analyze a dense grid of high-resolution seismic reflection data and present a new mapping of the Santa Monica Bay segment of the PVFZ, including multiple active splays (e.g., Redondo Canyon fault zone) that occur within a broad damage zone at the northern termination of the fault system. Based on these insights and prior studies, we develop a new, comprehensive 3D model of the PVFZ including its Santa Monica Bay, San Pedro Bay, and Lasuen Knoll segments. The sizes of these segments indicate that PVFZ is capable of larger events than previously reported—Mw 7.1–7.4 for single-segment ruptures and Mw 7.4–7.8 for multisegment ruptures. Based on a reported slip rate of 1.1–5.9 mm/yr, average recurrence intervals for these single- and multisegment rupture scenarios are 580–610 and 760–1170 yr, respectively.
Proses metakognitif siswa dalam menyelesaikan masalah matematika berdasarkan gaya belajar VAK (visual, auditori, dan kinestetik)
Authors: Lamowa Rachmad Abubakar , Irawati Santi , Subanji Subanji 
Published: July 2022

This study aims to describe students' metacognitive processes in solving mathematical problems based on the VAK (Visual, Auditory and Kinesthetic) learning style. The research method used in this research is descriptive qualitative. The research was conducted in the eighth grade of MTs Satu Atap Al-Hidayah on Jl. Pattimura Gg. VI No. 300 Gelonggong Temas, Batu City. Students are identified their learning styles through questionnaires and then given questions related to solving problems that are open-ended. Of the 15 students studied, there were three students with a visual learning style, three students with an auditory learning style and five students with a kinesthetic learning style. The results of the analysis show that the best metacognition process occurs in students with visual learning styles which are indicated by the achievement of the most indicators and followed by students with kinesthetic learning styles and then students with auditory learning styles. The results showed that the learning style did not significantly affect the students' metacognition process, but rather the understanding of the concept.
Training of future psychologists on suicide prevention among adolescents based on work with parents
Authors: Ainagul Rustemova , Kalipa Atemova , Aida Nurbekova , Ardak Alipbek , Mentay Shagyrbayeva 
Published: July 2022

The aim of this study is to reveal the views of future psychologists on the training of suicide prevention among adolescents based on work with parents. The study was designed with a phenomenology pattern. The study data were collected with a semi-structured interview form prepared with questions suitable for the purpose of the study. The sample of the study consisted of psychologist candidates studying in Kazakhstan. As a result of the research, among the answers given to the question about the causes of suicide in adolescents were family, loneliness, hopelessness, psychological problems and temperament, and most of the participants answered psychological problems. Among the answers given to the question about determining what should be done in order to prevent suicide in adolescents based on working with parents were family education, early diagnosis, guidance of adolescents, prevention of alcohol and substance consumption, and the majority of the participants answered family education. The majority of the participants in the closed-ended question about the determination of the proficiency of future psychologists in preventing suicide in adolescents based on working with parents stated ‘I definitely do not find it sufficient’. Among the answers given to the question about increasing efficacy in preventing suicide in adolescents based on working with parents were in-service trainings, experience and practice for disadvantaged groups, and the majority of the participants answered the question as in-service trainings.
Keywords: Suicide, adolescent, parent, education;
Models of psychological support of education in university
Authors: Gridneva S. V. , Tashcheva A. I. , Arpentieva M. R. 
Published: July 2022

Introduction. In the article the most widely used models of academic psychological support as basic ones for many universities in the world are supposed to be a systemic nature. All these models postulate the importance of systematic, targeted and operational assistance to the subjects of education. All these models proceed from the fact that almost all students and teachers of modern universities in one way or another face many psychological problems that can adversely affect the academic performance of the former and the success of the latter. Purpose setting. The purpose of the study is to analyze the models of psychological support of the educational process as a sphere of numerous types of helping a person to a person in solving the tasks facing him of coping with crises of personal, interpersonal and educational and professional development. Methodology of the study. The research method is a theoretical analysis of common models of academic support for the psychological well-being of subjects of the educational process. Modern models are analyzed that allow purposefully and systematically (multilevel and multidimensional), promptly and effectively provide corrective and developmental psychological assistance to the subjects of the educational process. Results. Universities, as institutions of culture, its transmission and production, are important centers of life for students and teachers. They are communities with interdisciplinary systems of collaboration and support and serve to ensure that all entities are provided with the affordable, quality, ongoing care they sometimes desperately need. Comprehensive, culturally sensitive university services can help eliminate and prevent inequalities in access to education and its academic support, help to reduce the restrictions associated with receiving psychological and other services, making them part of the educational system. Ensuring the continuity of mental health services is critical to effectively meeting the wide range of needs of learners. Comprehensive mental health services are most effective when they are delivered through systemic practices: a layered and multidimensional system of the other two structures, as presented in the Positive Behavior Interventions and Supports (PBIS) programs, Intervention Response Model (RTI) and other domestic and foreign models. Conclusion. High-quality, timely and targeted aid and support for educational subjects in various types of educational and life situations can significantly improve the quality of education and, among other things, make a significant contribution to the improvement of the society as a whole. Domestic support experience needs to be enriched with elements and principles of developments and models common in the modern foreign world, including those that increase the timeliness and relevance (accessibility) and quality (intensity and effectiveness) of assistance.
Modeling the process of pre-adaptation of medical college students to the uncertainty of the professional future
Authors: Chupina V. A. , Sokolova S. R. 
Published: July 2022

Introduction. The world of professions of the future in the field of medicine is in transformation constantly, acquiring features of dynamism, unpredictability and uncertainty, that’s why pre-adaptation of medical college students to the uncertainty of the professional future plays an important role in vocational training. Uncertainty of the professional future of today’s youth and radical transformations of the socio-professional environment require qualitative changes in secondary vocational education, revision of its methodology, content and technologies for training medical personnel for the post-industrial economy. Purpose setting. The purpose of the study is to develop and theoretically and methodologically justify the structural and functional model of the process of pre-adaptation of medical college students to the uncertainty of their professional future, the introduction of which into the educational process of institutions of secondary vocational education will achieve the desired result ‒ the readiness of medical students for the uncertainty of their professional future. Methodology of the study. The methodological basis of the study was systemic, competency-based, personalized, design and technological, contextual, and process approaches and the principles of mobility, variability, integrativity, reflexivity, focus on professional self-determination. The leading research method was the modeling method. Results. The simulation result is a structural-functional model of the process of pre-adaptation of medical college students to the uncertainty of their professional future, which includes four interrelated blocks: target, methodological, procedural-substantial and result-evaluative. The model allows forming the anticipatory readiness of medical students for professional activities in conditions of high uncertainty, instability and variability. It has the property of dynamism and openness for constant renewal. Conclusion. Scientific novelty is as follows: the essence and structure of the basic concepts are determined; justified the principles and methods of the process of pre-adaptation; a structural-functional model has been developed; substantiated and described organizational-pedagogical conditions. The results of the scientific work also allow us to outline the prospects for further research, which consist in the practical implementation of this model, the inclusion of the process of pre-adaptation in educational activities and the development of mechanisms for its evaluation from the standpoint of achieving the expected effects. The results can be applied by teachers in the process of professional education.
Inclusive education today: challenges and perspectives
Authors: Smirnova M. V. , Yeroma M. V. , Trofimova I. B. , Zinchenko M. V. 
Published: July 2022

Introduction. Today, the problems of inclusive education are particularly acute. This applies not only to Russia, but also to the world as a whole. In the historical context, the realization of its necessity has become a long process. This is primarily due to the fact that the introduction of inclusive education entails the formation of a new culture of society and the transformation of established principles. Purpose setting. The article presents the process of formation of the inclusive education system in Russia and its current state. The features of this process are considered on the basis of the analysis of the problem of inclusion of autistic children in the educational process, the features of their behavior affecting the process of social adaptation. The problem of combining ordinary children and children with problematic social behavior is highlighted. The prospects and the role of additional education in this process and the development of the abilities of children with disabilities in general, as well as social factors affecting its effectiveness are considered. Methodology of the study. As a result of the analysis of factors influencing the process of education and socialization of autistic children, complex research methods are proposed, including the use of various pedagogical and educational means. Results. As a solution to the problem, the creation of additional education centers combining various fields of activity is proposed. The basis of such centers should be competent managers capable of thorough scientific understanding of the management process and making non-standard bold decisions. Conclusion. The decisive factor in the success of the educational and educatve process when working with autistic people is the training of managers who are able to make non-standard decisions taking into account the individual situation, the psychological readiness of the team for social transformations.
Risk Management in the Manufacturing and Use of the Medical Product for <i>in vitro</i> Diagnostics: Reagent Kit “Lyophilized Erythrocyte Antigenic Tularemia Diagnosticum”
Authors: Startseva O. L. , Bogdanova Yu. V. , Gridina T. M. , Kurcheva S. A. , Koshkid’ko A. G. , Stepanishcheva A. S. 
Published: July 2022

The aim of the work was to implement the risk management strategies in the manufacturing and use of medical products for in vitro diagnostics by the example of the experimental series of the reagent kit “Lyophilized erythrocyte antigenic tularemia diagnosticum”.Materials and methods. We tested experimental series of the reagent panel “Lyophilized erythrocyte antigenic tularemia diagnosticum”. To carry out the identification, assessment and analysis of risks regarding the considered medical product, failure mode and effects analysis (FMEA) was proposed and adapted under production conditions. Identification of risks associated with manufacturing and control of medical products for in vitro diagnostics was carried out using technological regulations, standard operational procedures and manufacturing notes.Results and discussion. The main outcome of the study is the development of a corrective actions system aimed at reducing the risks and ensuring consistent monitoring. The proposed schemes for carrying out the risk management process can be used as standard ones in the design and development of medical products for in vitro diagnostics, taking into account the specifics of each individual manufacturing. The reporting documents developed within the framework of the system are applicable during the inspection of good manufacturing practice and in terms of completing the registration profile of a diagnostic product with subsequent registration in the healthcare system of the Russian Federation.
Zoning of the Territory of the Republic of Kazakhstan by the Degree of Intensity of the Epizootic Situation on Plague in Camels
Authors: Abdeliyev B. Z. , Dalibayev Zh. S. , Abdel Z. Zh. , Yerubayev T. K. , Baramova Sh. A. , Meka-Mechenko T. V. , Mussagalieva R. S. , Abdirassilova A. A. , Zhumadilova Z. B. , Umarova S. K. , Aimakhanov B. K. , Yessimseit D. T. , Rysbekova A. K. , Kassenova A. K. , Toyzhanov B. K. , Kulbaeva M. M. , Rametov N. M. , Sadovskaya V. P. 
Published: July 2022

The aim of the study was to improve epizootiological monitoring and increase the effectiveness of preventive (anti-epidemic) measures for camel plague control in Kazakhstan.Materials and methods. We used the data on epizootiological and epidemiological monitoring in natural plague foci of Kazakhstan, long-term measurements and indicators for the period of 2000–2020 of the anti-plague and veterinary services of the Republic for the analysis. To process the evidence, epidemiological, epizootiological, microbiological, and statistical research methods, as well as GIS technology were applied.Results and discussion. The number of camels has increased by 2.2 times in Kazakhstan over the past 20 years. Where there were 98.2 thousand heads in 2000, it amounted to 216.4 thousand heads in 2020. Over the past 10 years, 152 camels died of unknown causes in the focal area of the country, but laboratory tests for plague turned out negative. According to the hazard criteria, the territory of the country has been conditionally divided into three zones: five regions with a high degree of hazard with a total area of 953.15 sq. km, five regions with medium degree of hazard with a total area of 1230.72 sq. km, and with a low degree of hazard – four regions and three cities of republican significance with a total area of 541.1 sq. km. Constant epizootiological monitoring over plague in camels is a necessity for the system of preventive measures.
Investigating the stability of the Properties of Vibrio cholerae strains – Producers of Active Components of the Chemical Cholera Vaccine
Authors: Durakova O. S. , Vorob’eva S. A. , Gaeva A. V. , Krasnov Ya. M. , Kuznetsov O. S. , Erokhin P. S. , Gromova O. V. , Volokh O. A. 
Published: July 2022

One of the key requirements to producer strains used in the manufacturing of immunobiological preparations is their stability, which consists in maintaining the main cultural, morphological, physiological, and productive properties in a series of generations. This paper describes a comprehensive methodological approach to testing strain stability using in vitro techniques.The purpose of this study was to conduct an integrated analysis of the stability in the strains that produce active components of the chemical cholera vaccine when preparing seed material and at the stage of cultivation.Materials and methods. Toxigenic strains of Vibrio сholerae 569B of the classical biovar, serovar Inaba and V. сholerae M-41 of the classical biovar, serovar Ogawa were used in the work. Cell morphology was monitored through light and transmission electron microscopy. Atomic force microscopy was applied to measure the main parameters of the bacterial cell. The strains were tested for the presence of ctxA gene in the chromosome using the “GenChol” test system with electrophoretic registration of results. Whole genome sequencing of the strains was performed on the Ion Torrent PGM platform using the Ion 318 Chip Kit and the Ion PGM Hi-Q View Chef 400 Kit. To determine the specific activity of cholera toxin and O-antigen, a DOT immunoassay with a conjugate based on staphylococcal protein A and colloidal gold nanoparticles was applied.Results and discussion. The stability of the main properties of industrial V. сholerae strains – producers of the active components of the chemical cholera vaccine has been confirmed using microbiological, immunochemical, molecular-genetic methods and microscopic analysis at all stages of cultivation, and the prospects for using the integrated methodological approach experimentally substantiated. Tailoring of these methods will make it possible to control the stability of producer strains, optimize cultivation conditions and, as a result, increase the yield of the necessary antigenic component of the vaccine.
Tracing the Spatial Circulation of Yersinia pestis of Medieval Biovar in the Eastern Caspian Sea Region in the 20th Century Based on Genome-Wide SNP Analysis
Authors: Eroshenko G. A. , Oglodin E. G. , Balykova A. N. , Krasnov Ya. M. , Naryshkina E. A. , Ayazbaev T. Z. , Popov N. V. , Kutyrev V. V. 
Published: July 2022

A comprehensive analysis of the accumulated epidemiological and epizootiological data in combination with results from phylogenetic analysis of Yersinia pestis strains creates the basis for establishing patterns of spatialtemporal distribution of the plague pathogen and opens up the prospect of long-term forecasting of natural plague foci activation. Previously, we traced the distribution pathways of Y. pestis, medieval biovar, in the plague foci of the Northern and Northwestern Caspian Sea regions in the 20th and early 21st centuries.The purpose of this work was to identify the regularities of circulation of Y. pestis, medieval biovar, in four natural plague foci located in the Eastern Caspian Sea region.Materials and methods. A complex study of the phenotypic and genetic properties of 16 Y. pestis strains isolated in the Ustyurt, Mangyshlak, Karakum and Kopetdag autonomous desert plague foci in 1926–1985 was carried out. They were compared with strains from other natural plague foci in Eastern Europe and Central Asia obtained in 1917–2003. Whole-genome sequencing of 12 of those strains was performed. Phylogenetic analysis included the genomes of other 19 Y. pestis strains that we had sequenced earlier. Based on the 1717 polymorphic nucleotides (SNPs) identified in the core genome, a dendrogram of the relations of the studied strains was constructed.Results and discussion. All 16 Y. pestis strains from the Ustyurt, Mangyshlak, Kopetdag, and Karakum desert foci belong to the 2.MED1 branch of the medieval biovar. All investigated strains from the first three foci and most of the strains from the Karakum focus are in the Caspian 2.MED1 branch, and three strains from the Karakum desert focus are included in the Central Asian one. We have revealed several waves of dissemination of the strains under the 2.MED1 phylogenetic branch of Y. pestis of the medieval biovar in the Eastern Caspian Sea region in the 20th century.
Experimental Peroxidase Conjugate for Detection of Specific Antibodies to Anthrax Agent in Enzyme Immunoassay
Authors: Kurcheva S. A. , Kurnoskina M. M. , Zharnikova I. V. , Koshkid’ko A. G. , Rusanova D. V. , Ryazanova A. G. , Aksenova L. Yu. , Kovalev D. A. , Zhirov A. M. , Kulichenko A. N. 
Published: July 2022

Anthrax poses a pressing issue for veterinary medicine and public health in many countries, including the Russian Federation, which necessitates the improvement and development of new, sensitive and specific diagnostic tools.The aim of the work was to create an experimental peroxidase conjugate for the detection of specific antibodies to the anthrax pathogen and to optimize the conditions for performing enzyme immunoassay (ELISA).Materials and methods. The peroxidase conjugate was constructed using horseradish peroxidase and Staphylococcus aureus protein A (Sigma-Aldrich, USA). Bacterial antigens isolated from strains of Bacillus anthracis 55ΔTPA-1Spo, B. anthracis Sterne 34 F2 were used as sensitizing agents. The developed experimental batches of the conjugate were tested in ELISA for the ability to bind antibodies in the blood sera of anthrax patients and vaccinated individuals. The sensitivity, specificity, and accuracy of the method were calculated using the built-in functions of the ROCR software package.Results and discussion. The peroxidase conjugate to detect specific antibodies to the anthrax pathogen in the study of clinical material has been developed; conditions for the ELISA performance have been optimized. To interpret the results of the study, a threshold value of the positivity coefficient was used, below which the result was considered negative, and at an equal or higher value, positive. The test demonstrated significant differences in the “positivity coefficient” indicator for the “Healthy”/“Sick” and “Healthy”/“Vaccinated” groups, while the differences between the “Sick”/“Vaccinated” groups were statistically insignificant. The maximum accuracy of the method was observed at blood serum dilutions of 1:250 and 1:500. 100 % intra-run, run-to-run and series-to-series reproducibility has been established for all positive samples. The sensitivity and specificity of the experimental peroxidase conjugates were 100 and 95.8 %, respectively, and the accuracy was 97.6 %.