bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interrogating Metabolic Interactions Between Skeletal Muscle and Liver Circadian Clocks In Vivo
Authors: Smith Jacob G. , Koronowski Kevin B. , Sato Tomoki , Greco Carolina , Petrus Paul , Verlande Amandine , Chen Siwei , Samad Muntaha , Deyneka Ekaterina , Mathur Lavina , Blazev Ronnie , Molendijk Jeffrey , Mortimer Thomas , Kumar Arun , Deryagin Oleg , Vaca-Dempere Mireia , Liu Peng , Orlando Valerio , Parker Benjamin L. , Baldi Pierre , Welz Patrick-Simon , Jang Cholsoon , Masri Selma , Benitah Salvador Aznar , Muñoz-Cánoves Pura , Sassone-Corsi Paolo 
Published: February 2022

AbstractExpressed throughout the body, the circadian clock system achieves daily metabolic homeostasis at every level of physiology, with clock disruption associated with metabolic disease (1, 2). Molecular clocks present in the brain, liver, adipose, pancreas and skeletal muscle each contribute to glucose homeostasis (3). However, it is unclear; 1) which organ clocks provide the most essential contributions, and 2) if these contributions depend on inter-organ communication. We recently showed that the liver clock alone is insufficient for most aspects of daily liver glucose handling and requires connections with other clocks (4). Considering the pathways that link glucose metabolism between liver and skeletal muscle, we sought to test whether a clock connection along this axis is important. Using our previous published methodology for tissue-specific rescue of Bmal1 in vivo (4, 5), we now show that in the absence of feeding-fasting cycles, liver and muscle clocks are not sufficient for systemic glucose metabolism, nor do they form a functional connection influencing local glucose handling or daily transcriptional rhythms in each tissue. However, the introduction of a daily feeding-fasting rhythm enables a synergistic state between liver and muscle clocks that leads to restoration of systemic glucose tolerance. These findings reveal limited autonomous capabilities of liver and muscle clocks and highlight the need for inter-organ clock communication for glucose homeostasis which involves at least two peripheral metabolic organs.
Telomerase deficiency in humans is associated with systemic age-related changes in energy metabolism
Authors: James Emma Naomi , Sagi-Kiss Virag , Bennett Mark , Mycielska Maria , Peng Karen-Ng Lee , Roberts Terry , Matta Sheila , Dokal Inderjeet , Bundy Jacob Guy , Parkinson Eric Kenneth 
Published: February 2022

SUMMARYUnderlying mechanisms of plasma metabolite signatures of human ageing and age-related diseases are not clear but telomere attrition and dysfunction are central to both. Dyskeratosis Congenita (DC) is associated with mutations in the telomerase enzyme complex (TERT,TERC,DKC1) and progressive telomere attrition. We show extracellular citrate is repressed by canonical telomerase functionin vitroand associated with DC leukocyte telomere attritionin vivo;leading to the hypothesis that altered citrate metabolism detects telomere dysfunction. However, citrate and senescence factors only weakly distinguished DC patients from controls, whereas other tricarboxylic acid cycle metabolites, lactate and especially pyruvate distinguished them with high significance, consistent with further metabolism of citrate and lactate in the liver and kidneys. Citrate uptake in certain organs modulates age-related disease in mice and our data has similarities with age-related disease signatures in humans. Our results have implications for the early diagnosis of telomere dysfunction and anti-senescence therapeutics.HighlightsExtracellular citrate is regulated by telomere functionin vitro and in vivo.Dyskeratosis Congenita (DC) is a human disease characterized by systemic telomere attrition, which showed an age-related plasma energetic profile, distinct from age-related disease and that of centenarians.The DC profile strikingly out-performed senescence factors in discriminating DC from controls, and pyruvate associated with a low lactate:pyruvate ratio is potentially a useful and cheap minimally invasive diagnostic aid for DC and telomere dysfunction.Mechanistically DC systemic metabolism is indicative of a shift to reduced pyruvate dehydrogenase activity, glycolysis and/or increased citrate and lactate production followed by further metabolism in the kidneys and liver.
Combined effects of inlet airflow temperature and upper expansion angle on the performance of scramjet nozzle
Authors: Sun Yifang , Duan Chunxu , Li Renfu , Li Chenghu 
Published: February 2022

Purpose
The purpose of this paper is to study the combined effects of inlet airflow temperature and the expansion angle of the upper expansion surface (upper expansion angle) on the performance of the scramjet nozzle.

Design/methodology/approach
The Spalart-Allmaras turbulence two-dimensional model of the nozzle is established for the study. The influence of inlet airflow temperature on the performance of the nozzle is analyzed by detecting the change of the wall pressure of the nozzle. The three angles are chosen for the upper expansion angle (βb) in the model: 8°, 12° and 16°. The temperature of inlet airflow is 600–1,800 K.

Findings
The study results show that when the βb is 8° and 16°, the wall pressure of the nozzle has a complicated and large fluctuation with the inlet airflow temperature, while the wall pressure has little change as βb is 12°; the thrust coefficient, pitching moment coefficient and lift coefficient of the nozzle fluctuate greatly with the increase of the inlet airflow temperature when βb is 8° and 16°, while the thrust coefficient, pitching moment coefficient and lift coefficient have little fluctuation as βb is 12°.

Originality/value
The study of the combined effects of the inlet airflow temperature and upper expansion angle on the performance of the scramjet nozzle can provide guidance for the design of scramjet nozzles.
Optimization of triage time and sample delivery path in health infrastructure to combat COVID-19
Authors: Zhou Cheng , Li Rao , Xiong Xiaoju , Li Jie , Gao Yuyue 
Published: February 2022

PurposeThis study presented the experience of improving the nucleic acid sample collection and transportation service in response to the epidemic. The main purpose is that through intelligent path planning, combined with the time scheduling of sample points, the process of obtaining results to determine the state of COVID-19 patients could be speeding up.Design/methodology/approachThe research optimized the process, including finding an optimal path to traverse all sample points in the hospital area via intelligent path planning method and standardizing the operation through the time sequence scheduling of each round of support staff to collect and send samples in the hospital area, so as to ensure the shortest time in each round. And the study examines these real-time experiments through retrospective examination.FindingsThe real-time experiments' data showed that the proposed path planning and scheduling model could provide a reliable reference for improving the efficiency of hospital logistics. Testing is a very important part of diagnosis and prompt results are essential. It shows the possibility of applying the shortest-path algorithms to optimize sample collection processes in the hospital and presents the case study that gives the expected outcomes of such a process.Originality/valueThe value of the study lies in the abstraction of a very practical and urgent problem into a TSP. Combining the ant colony algorithm with the genetic algorithm (ACAGA), the performance of path planning is improved. Under the intervention and guidance, the efficiency of hospital regional logistics planning was greatly improved, which may be of greater benefit to critical patients who must go through fever clinic during the epidemic. By detailing how to more rapidly obtain results through engineering method, the paper contributes ideas and plans for practitioners to use. The experience and lessons learned from Tongji Hospital are expected to provide guidance for supporting service measures in national public health infrastructure management and valuable reference for the development of hospitals in other countries or regions.
Saudi Arabia’s small and medium enterprises (SMES) sector post-Covid-19 recovery: stakeholders’ perception on investment sustainability
Authors: Alharbi Raed Khamis 
Published: February 2022

Purpose
The sound viability of small and medium enterprises (SMEs) positively influences nations’ economic growth. Studies investigating the impact of the Covid-19 pandemic on SMEs in Saudi Arabia (KSA) and how the owners will source for working capital and short-term loans to kick start in the post-Covid-19 recovery are scarce. Hence, this study aims to investigate the perceived negative impact of Covid-19 on SMEs and suggests policy solutions to improve access to finance and investment sustainability for the SMEs owners in the post-Covid-19 recovery via the stakeholders’ perception in KSA.

Design/methodology/approach
The paper sourced data from Medina, Riyadh and Alqassim via virtual interviews. The study engaged SMEs owners, government agencies and banks within the covered regions in KSA. The sourced data were analysed via a thematic, and the results were presented in themes.

Findings
The findings show that the SMEs sector plays a pertinent role in KSA gross domestic product growth. But, the recent ravaging of the SME sector by the Covid-19 pandemic was adversely unprecedented, and stakeholders were caught unaware. The paper categorised the perceived impacts into most severe, severe and fairly severe. The findings show that SMEs sector post-Covid-19 recovery will require access to finance-friendly policies to revive the unique sector. This should be supported with an enabling business environment via policies that encourage investment and sustainability to achieve KSA Vision 2030.

Research limitations/implications
The study is restricted to the impact of the Covid-19 pandemic on SMEs and data collected via virtual interviews across three cities in KSA. Other developing Islamic nations can modify the policy suggestions from this paper to improve their SMEs sectors.

Practical implications
The significance of a robust SMEs sector to grow the economy has been established. The emerged recommendations from this paper may provide insights to the policymakers and other stakeholders. This will enhance the rebuilding of the SMEs sector across KSA in the post-Covid-19 era.

Originality/value
This study is unique because it investigated the impacts of the ravaging pandemic on SMEs owners and proffered possible solutions for quick post-Covid-19 recovery from the KSA stakeholders’ perspective.
COVID-19 on an acute psychiatric unit: an interdisciplinary, trauma-informed response
Authors: Carroll Laura , Casey Hannah , Adams Rory , O’Connor Stephanie , O’Reilly Áine 
Published: February 2022

Purpose
There is a high prevalence of trauma among mental health clients, with risk of re-traumatisation when admitted to a Department of Psychiatry (DoP) (Kimberg and Wheeler, 2019). The COVID-19 pandemic poses challenges to therapy service operations in DoPs, with infection control measures impacting opportunities for therapeutic and social engagement. A trauma-informed care (TIC) lens was used when adapting services in Tallaght University Hospital DoP in response to COVID-19.

Design/methodology/approach
An interdisciplinary approach was taken to adapt therapy services during early stages of the pandemic. Changes were informed by TIC principles to minimise re-traumatisation while maintaining high-quality services. Changes included expansion of the therapeutic activity programme, changes to groups, addition of COVID-19-specific groups and increased awareness of communication support needs.

Findings
The early response to the pandemic, combined with the focus on TIC, resulted in continued, effective therapy services and positive client feedback. With clients’ involvement in their care enhanced, Individual Care Planning goals were achieved through group interventions.

Originality/value
The COVID-19 pandemic brought unprecedented changes to mental health services. This paper highlights a response to unique challenges brought by COVID-19 on a DoP.
Experimental study on reciprocating magnetorheological polishing
Authors: Wang Rensheng , Sun Cong , Xiu Shichao , Li Bo , Zhang Xiaohua 
Published: February 2022

Purpose
This paper aims to study the effects of the different processing parameters in the reciprocating magnetorheological polishing (RMRP) on the surface roughness (Ra) and material removal rate (MRR) of the workpiece surface.

Design/methodology/approach
The principle of RMRP method is discussed, and a series of the single factor experiments are performed to evaluate the effects of the workpiece’s rotational speed, the reciprocating frequency, the magnetic field strength, the working gap and the processing time on machining results using the RMRP device.

Findings
The RMRP method is effective and practical for K9 glass polishing, and the optimized processing parameters are obtained by the single factor experiments of RMRP. The surface roughness of the workpiece is reduced from 332 nm to 28 nm under optimized processing parameters.

Originality/value
In the present study, the RMRP method is proposed, and a system of experiments is carried out using the RMRP device. The RMRP device can improve the surface roughness and MRR of the K9 glass significantly. Furthermore, the test results provide references for reasonable selection of the processing parameters in magnetorheological polishing process.
Framework development and evaluation of Industry 4.0 technological aspects towards improving the circular economy-based supply chain
Authors: Agarwal Somesh , Tyagi Mohit , Garg Rajiv Kumar 
Published: February 2022

PurposeThe purpose of this study is to present Industry 4.0 technologies for advancing the circular economy (CE) adaption in manufacturing industry’s supply chain (SC) network. To pursue the same, Industry 4.0 technological aspects were recognized as solution measures to overcome the challenges for CE implementation in SC.Design methodology approachA new hierarchical framework containing 13 leading CE challenges and eight promising Industry 4.0 technological aspects had been proposed, representing their mutual relationship. The proposed framework was analysed using a hybrid approach of analytic hierarchy process (AHP) and combinative distance-based assessment (CODAS) under interval-valued intuitionistic fuzzy (IVIF) environment. The IVIF-AHP was used to acquire the priority weights of the CE challenges, whereas the IVIF-CODAS was used to attain the preference order of the proposed technological aspects.FindingsThe key findings of the present work indicate that “Information disruptions among the SC members due to multiple channels” and “Manpower inability to handle the toxic materials” are the two most critical challenges hindering the adoption of CE practices in SC. Along with, the results also demonstrate that to overcome these challenges, “Smarter equipment to empower flexibility and mass customization” and “Big data driven decision-making system” are the two most significant Industry 4.0 technological solutions, adoption of which might encourage the organizations to align their operations with CE philosophies.Research limitations implicationsThe sample size of the experts engaged in work was limited; however, big data studies could be conducted in future to capture more insights of the stated topic. In addition to this, to understand the implication of CE on Industry 4.0-based manufacturing, a separate study can be synthesised in future.Originality valueThe proposed work facilitates a new framework consolidating various perspectives associated with CE implementation into a manufacturing industry considering the scenario of Indian rubber industry. This study enables the decision-makers to recognize the challenging factors for CE implementation into their organizations and up-taking the proposed Industry 4.0 practices as technological measures for improving the organization overall performance.
Determination of managerial resourcefulness in the Turkish hospitality industry: a grounded theory study
Authors: Ersoy Aslı , Ehtiyar Rüya 
Published: February 2022

Purpose
The purpose of this study is to use the grounded theory approach to develop a theoretical understanding of managerial resourcefulness in Turkish culture from the perspective of both hospitality managers and subordinates.

Design/methodology/approach
This study adopts the grounded theory approach to systematically analyze the real experience of participants. Semi-structured interviews were conducted with 55 participants, namely, 15 general managers and 40 department managers of five star hotels in Antalya. Computer-based qualitative data analysis software (NVivo 10) was used to analyze the data.

Findings
The data from the interviews suggest that Turkish managers can regulate their emotions, thoughts, and behaviors while performing their managerial tasks. Furthermore, they are acutely aware of the role of subordinates in maximizing managerial and organizational efficiency and place such priorities at the center of the organization. The role of culture on managerial resourcefulness is visible. Despite this, organizations are not affected by the high power distance culture within the country. Specifically, managers have a management model based on mutual trust with their subordinates, giving importance to their feelings, thoughts and well-being, communicating strongly with them, expressing appreciation and gratitude for them, and emphasizing human values.

Originality/value
The paper is the first attempt to develop a hotel-specific model of managerial resourcefulness, which could serve as a theoretical foundation in the further examination of managerial resourcefulness. Therefore, this study contributes to the existing literature by shedding light on the importance of sector-specific competencies in effectively managing subordinates in Turkish culture.
Determinants of Islamic banking adoption among non-Muslim customers in a Muslim zone
Authors: Ezeh Precious Chikezie , Nkamnebe Anayo D. 
Published: February 2022

Purpose
The purpose of this study is to establish the relationship between relative advantage, social influence, trust, compatibility, knowledge and adoption of Islamic banking among non-Muslim bank customers in a Muslim zone of Nigeria.

Design/methodology/approach
Usable questionnaires were received from 350 participants. Structural equation modeling is used to assess the relationships between latent unobserved constructs. Composite reliability and average variance extracted were used to test the reliability and validity of the instrument. This study uses the correlational research design to test the hypotheses.

Findings
The findings indicate that relative advantage, social influence, trust and compatibility significantly influence adoption of Islamic banking among non-Muslim customers in a Muslim zone of Nigeria. However, knowledge of Islamic banking operations does not significantly influence adoption of Islamic banking.

Originality/value
The existing literature focuses on factors that influence the adoption of Islamic banking, without due emphasis on non-Muslims. The religious divides of Nigeria compel this research to determine the factors that influence the adoption of Islamic banking among non-Muslim customers. Hence, this research seeks to bridge the gap in the existing literature by embarking on an investigation using innovation diffusion theory to identify factors influencing the adoption of Islamic banking among non-Muslim customers in the Nigerian context.
Digital technology driven knowledge sharing for job performance
Authors: Deng Hepu , Duan Sophia Xiaoxia , Wibowo Santoso 
Published: February 2022

Purpose
The purpose of this study is to investigate how digital technologies are used for facilitating knowledge sharing and decision-making through enhanced coordination and communication and their impact on job performance in organizations.

Design/methodology/approach
A conceptual model is developed within the background of the social capital theory through a comprehensive review of the related literature for exploring how digital technologies can improve knowledge sharing and decision-making via enhanced communication and coordination between individuals in organizations for better job performance. This model is then tested and validated based on structural equation modeling of the collected survey data in Australia.

Findings
This study shows that digital technology enhanced coordination and communication have significant impact on knowledge sharing. It finds out that digital technology driven coordination significantly influences decision-making and digital technology driven knowledge sharing significantly influences decision-making. Furthermore, this study reveals that enhanced decision-making and knowledge sharing can lead to better job performance in organizations.

Originality/value
To the best of the authors’ knowledge, this study is the first attempt to explore the role of digital technologies in enhancing knowledge sharing and decision-making for better job performance in a digitalized working environment in organizations. The validated model can be used as the foundation to further investigate the changing role of digital technologies in driving knowledge sharing for better performance of individuals and competitive advantages of organizations.