bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gamma-Tocotrienol Synergistically Promotes the Anti-proliferative and
Pro-apoptotic Effects of Etoposide on Breast Cancer Cell Lines
Authors: Rizk Sandra , Idriss Maya , Younes Maria , Abou Najem Sonia , Hodroj Mohammad Hassan , Fakhoury Rajaa 
Published: February 2022

Background:
Breast Cancer is one of the most commonly diagnosed cancers worldwide and a major cause of death among women. Although chemotherapeutic agents remain the keystones in cancer therapy, significant side effects have failed to provide a safe and tolerable treatment for cancer patients. Dietary antioxidant vitamins were extensively investigated over the past years and their relevance in cancer chemotherapy remains to be elucidated.

Objective:
In the current study, we aimed to investigate the anti-proliferative and apoptotic effects of combining γ-tocotrienol, a member of the vitamin E family, with the chemotherapeutic drug etoposide in MCF-7 and MDA-MB-231 breast cancer cell lines.

Methods:
The antiproliferative effect of etoposide combined with γ-tocotrienol was measured using MTS viability reagent. The pro-apoptotic effect was elucidated through Cell Death ELISA and dual Annexin V/PI staining followed by flow cytometric analysis.

Results:
Our results showed that etoposide significantly decreased the cell growth of both cell lines, with MDA-MB-231 cells being more sensitive to etoposide treatment than MCF-7. Moreover, sim-ultaneous treatment of both breast cancer cell lines with low doses of γ-tocotrienol and etoposide induced a synergistic antiproliferative effect (CI<1). Furthermore, the combination therapy signifi-cantly increased the percentage of total apoptotic cells in the MDA-MB-231 cell line and the degree of DNA fragmentation as compared to treatment with either compound alone.

Conclusion:
In conclusion, our results provide evidence for the profound anti-tumorigenic effect of combined etoposide and γ-tocotrienol in the breast cancer cell lines.
Introduction to Re@ct: Social Change Art Technology
Authors: DeLappe Joseph , Leuzzi Laura 
Published: February 2022

This is the Introduction to the special issue Re@ct: Social Change Art Technology, co-edited by Sarah Cook, Joseph DeLappe, and Laura Leuzzi. The issue gathers essays, artists' statements, and experimental writing projects from selected participants in a three-day symposium held in Dundee, Scotland in 2019, in partnership with the NEoN Digital Arts Festival.
Considerações sobre o sublime e a poética do movimento
Authors: Brazón Mariela 
Published: February 2022

O objetivo deste artigo é examinar os pontos de contato entre a arte cinética e a poética do sublime, explorando diálogos com outras categorias estéticas e relações com expressões artísticas em que o sublime é manifestamente tratado. Para o desenvolvimento das ideias, usamos como referências as análises de Julian Bell, Barnett Neuman e Robert Rosemblum. No que diz respeito à arte do movimento, o ponto de partida foi a revisão histórico-crítica de Frank Popper, com destaque para suas colocações sobre a estética do sublime. Foram identificadas pelo menos três abordagens para o problema: as relações com a natureza, a imersão na luz e na cor, e o espírito de sacralidade presente em momentos de criação e revelação.
Palavras chaves
Sublime, Arte cinética, Arte do movimento
PREFERENSI GAYA ARSITEKTUR HUNIAN BERDASARKAN TIPE KEPRIBADIAN
Authors: Hasbi Rahil Muhammad , Dawanti Rizki 
Published: February 2022

Guna dan citra merupakan 2 unsur dari arsitektur yang tidak bisa dipisahkan. Guna merupakan fungsi dan struktur, citra menggambarkan estetika dari suatu karya arsitektur. Citra tidak hanya sekedar tentang estetika tetapi memiliki makna yang lain yang disebabkan oleh pentingnya budaya bagi masyarakat Nusantara. Selain dimensi guna, dimensi Citra juga perlu diperhatikan. Sebagai manusia yang berbudaya, maka dibutuhkan dimensi citra yang berkualitas karena tampilan arsitektur tidak hanya tampilan fungsi dan struktur saja. Manusia dapat memberikan makna dan jiwa pada bangunan/karya arsitektur dengan kegiatan dan kepribadian yang dimiliki oleh pemiliknya . Setelah diberikan ”jiwa” oleh penghuninya maka bangunan ini akan memiliki karakter yang dapat mencirikan penghuninya. Oleh karena itu penelitian ini bertujuan untuk melihat bagaimana preferensi setiap individu terhadap desain huniannya berdasarkan tipe kepribadiannya.Metode yang dipergunakan dalam penelitian ini adalah metode campuran kuantitatif dan kualitatif . Hasil dari penelitian ini adalah beberapa tipe kepribadian memiliki preferensi yang sama terhadap gaya arsitektur tetapi dengan tingkat preferensi yang berbeda, terdapat pola-pola preferensi terhadap desain hunian yang dipengaruhi oleh tipe kepribadian dan preferensi terhadap gaya arsitektur hunian berdasarkan tipe kepribadian dipengaruhi oleh faktor-faktor berikut; karakter desain, elemen arsitektur ,budaya, familiaritas, iklim dan lingkungan. Guna and Citra are inseparable in architectural design. Guna means function and structure of a building or built environment, citra means the art or the aesthetic of an architectural design. Citra is not just about art or aesthetics. It has other meanings due to the importance of culture for the people of Nusantara. Citra also needs to be considered because as human beings with culture, we need to enhance the aesthetic quality of a building or built environment through the Citra. Citra can convey what kind of personality the user has. Humans can give meaning and a 'soul' to a building / built environment through the activities carried out in it and through the personality of its users. So that, each building can show the characters of the user. Therefore, this study aims to see how each individual's preference for residential architectural style based on their personality type.The method of this research is a mixture of quantitative and qualitative methods. The results of this research are; several personality types have the same preference for residential architectural style but with different levels of preference, there are patterns of residential architectural style preference based on each personality of the user, and the preference for residential architectural style based on personality is influenced by the following factors; design characters, architectural elements, culture, familiarity, climate and environment.
Development of Improved Dense Graded Bituminous Macadam with Low Density polyethylene and High Density Polyethylene with Zykotherm Intermixing
Authors: Patel Anjana , Khan Afzal 
Published: February 2022

The utilisation of leftover polythene in flexible road constructions is discussed in this paper. In flexible pavements, recovered polymer debris such as carry bags from supermarkets and water bottles, coldrink bottles (LDPE) and plastic bottle caps (HDPE) have been utilised as additives. We'll also use a fixed amount of Zykotherm in this experiment (ZycoTherm is an odourless ingredient that boosts moisture tolerance while decreasing blending and compaction temperatures by up to 65°F). The aforementioned components were chosen for two reasons: to use economically and environmentally undesirable trash and to build a superior material mixture to withstand higher traffic loads, temperature effects, and pressure, which results in fractures in the pavement surface. The polymer debris will be processed and reduced into a size that would flow through a 2-3mm filter in the research study utilizing a shredding machine.
In this investigation, a Dense Bituminous Macadam (DBM) mixture is being presented to be prepared utilizing pure bitumen as a control sample and bitumen blended with LDPE 2 percent and 4 percent & HDPE 2 percent, 3 percent, 4 percent, 5 percent by weight, with a specific amount of Zykotherm of 1.5 percent by weight. On control and modified DBM mixes, the Marshall Stability Test, Penetration Test, and Softening Point Test were performed.
Interakcja odmian pszenicy ozimej z warunkami środowiska w kształtowaniu poziomu plonowania na podstawie wyników PDO na dolnym Śląsku
Authors: WEBER RYSZARD , ZALEWSKI DARIUSZ , BUJAK HENRYK , KACZMAREK JAN , ŚMIAŁEK EWA 
Published: February 2022

Na podstawie wyników Porejestrowego Doświadczalnictwa Odmianowego (PDO) w latach 2007–2009 oceniano stabilność plonowania odmian pszenicy ozimej. Badania przeprowadzono w 7 miejscowościach, różniących się warunkami glebowymi i klimatycznymi. Analizowano plony 11 odmian w dwu wariantach uprawy. Wariant intensywny różnił się od standardowego większym o 40 kg . ha-1 nawożeniem azotowym, ochroną chemiczną przed chorobami grzybowymi, stosowaniem antywylegacza oraz dolistnym dokarmianiem roślin. Spośród badanych odmian w wariancie standardowym większym plonowaniem odznaczały się uprawy odmiany Cubus i Rapsodia, natomiast w wariancie intensywnym – Cubus i Nadobna. Zmienne warunki atmosferyczne, a szczególnie deficyt wody w okresie wegetacji roślin na lżejszych glebach, spowodowały mniejszą stabilność plonowania odmian pszenicy ozimej. Wykazana interakcja genotypowo- -środowiskowa wskazała, że dobór odmian do uprawy na terenie Dolnego Śląska powinien uwzględniać mikrozmienność środowiskową, na którą wpływają warunki glebowo-klimatyczne panujące w określonej miejscowości.
Co-governance, Social Responsibility and Economic Democracy
Authors: Zdravje Peter 
Published: February 2022

Abstract
This article contributes to the justification of social responsibility and economic democracy, which can create a sustainable society through co-governance
The word co-governance is not the same as co-management, although it is also very often used in translations that do not distinguish between management and governance. Rozman explains: “Owners-shareholders have started to employ professionals called managers to manage their companies. The once unified function of governance (and management) has been divided into two organizational functions: governance, making decisions to protect owners’ interests, and management, coordinating business activities in a most efficient way while striving to attain goals and execute policies set by governance.” (Rozman 2000, 95) Later he explains: “The goal remained profitability, and corporate governance was conducted on the basis of ownership but not necessarily by the owners themselves. This was the first form of ‘non-owners’ or ‘nonself-governance’. Corporate governance and management went separate.” (Rozman 2013, 4)
Clarke (1998, 182–194 as cited in Rozman 2013, 6) recalls of different stakeholders’ governance similar processes in the past, like mutual funds, cooperatives, Mondragon cooperatives, Israeli kibbutzes and Yugoslav self-governance.
in companies. Each of these areas is specifically described as well as the contribution of each to a sustainable society. Importantly, the message that capital, which predominates in the current socio-economic system, does not allow the development of co-governance of stakeholders in companies. This severely curtails the making of socially responsible decisions in companies, which does not contribute to the development of economic democracy. By equating the rights of labour owners with the rights of capital, the conditions of co-governance of stakeholders would be met, which would give them the right to self-actualization based on the results of their work. This would lead to the development of economic democracy and further to a sustainable society. A sustainable society, supported by the co-governance, social responsibility and economic democracy is the ultimate goal of society.
KORELASI SESAK NAPAS DENGAN OBSTRUKSI SALURAN NAPAS PADA PASIEN PENYAKIT PARU OBSTRUKTIF KRONIK
Authors: Khairani Rita , Qalbiyah Sakinah 
Published: February 2022

Latar Belakang: Penyakit paru obstruktif kronik (PPOK) merupakan penyakit inflamasi kronik saluran napas yang dapat menyebabkan obstruksi saluran napas dan ditandai dengan penurunan aliran udara yang persisten. Prevalensi di Indonesia mencapai 3,7% di tahun 2018. Pasien PPOK memiliki beberapa gejala, yaitu mengi, batuk, sesak napas serta produksi sputum yang bertambah yang disebabkan oleh obstruksi saluran napas.Penyakit ini dapat dicegah dan diobati, tetapi apabila disertai dengan seringnya eksaserbasi dan disertai komorbid maka kondisi pasien dapat memburuk.Metode yang digunakan adalah studi analitik dengan desain potong lintang. Pengambilan sampel dilakukan pada bulan November – Desember 2019 di RSUD Budhi Asih dengan cara consecutive non random sampling. Variabel yang diteliti adalah obstruksi saluran napas yang diukur menggunakan Peak Flow Meter dan sesak napas menggunakan kuesioner Modified Medical Research Council . Analisis univariat berupa distribusi frekuensi variabel yang diteliti. Analisis bivariat untuk menilai koefisien korelasi dengan uji normalitas Kolmogorov-Smirnov, uji korelasi Pearson variabel usia dan sesak napas dengan obstruksi saluran napas, uji T-Independent jenis kelamin dengan obstruksi saluran napas dengan tingkat kemaknaan p<0.05Pada studi ini didapatkan korelasi negatif yang kuat (r=-0.838) dan bermakna (p=0.000) antara skala sesak napas dengan arus puncak ekspirasi pada pasien PPOK.Kesimpulan : semakin tinggi skala sesak napas maka semakin rendah nilai arus puncak ekspirasi yang didapat
PENDIDIKAN YANG AMAN PADA MASA PANDEMI COVID-19
Authors: Wicaksono Arif , Nurfianty Arina 
Published: February 2022

Coronavirus Disease 2019 (COVID-19) pandemic hit in 2020. This pandemic was causing changes in almost all sectors in our life, including education. Most of the education carried out in Indonesia uses the direct / face-to-face/ offline method between educators and students. The spread of COVID-19 is through direct contact or contact with air or surface containing the virus. The unevenness of perceptions, examinations, and existing protocols causes fear of face-to-face education. This research is a review of articles on COVID-19, health and education protocols during the COVID-19 pandemic. Public perceptions including educators, students and families about COVID-19 must be equalized to fight the pandemic together and welcome online education which is the safest option in education during pandemic. AbstrakTahun 2020 terjadi pandemi Coronavirus Disease 2019 (COVID19). Pandemi ini menyebabkan perubahan di hampir semua bidang, termasuk pendidikan. Pendidikan yang dilakukan di Indonesia banyak yang menggunakan cara langsung/tatap muka antara pendidik dan peserta didik. Penyebaran COVID-19 adalah melalui kontak langsung atau bersentuhan dengan barang-barang yang mengandung virus. Belum meratanya persepsi, pemeriksaan, dan protokol yang ada menyebabkan ketakutan untuk melakukan pendidikan secara tatap muka. Penelitian ini merupakan telaah artikel mengenai COVID-19, protokol kesehatan dan pendidikan selama masa pandemi COVID-19. Persepsi masyarakat termasuk pendidik, peserta didik dan keluarga mengenai COVID-19 harus disamakan untuk bersama melawan pandemi dan menyambut pendidikan secara daring yang merupakan pilihan paling aman dalam pendidikan pada masa pandemi.
Communication: Multi-reference Approach to the Computation of Double-Core-Hole Spectra
Authors: Tenorio Bruno Nunes Cabral , Decleva Piero , Coriani Sonia 
Published: February 2022

Double-Core Hole (DCH) states of small molecules are assessed with the restrictedactive space self-consistent field (RASSCF) and multi-state restricted active space perturbationtheory of second order (MS-RASPT2) approximations. To ensure an unbiaseddescription of the relaxation and correlation effects on the DCH states, the neutralground state and DCH wave functions are optimized separately, whereas the spectralintensities are computed with a biorthonormalized set of molecular orbitals within thestate-interaction (SI) approximation. Accurate shake-up satellites binding energies andintensities of double-core-ionized states (K-2) are obtained for H2O, N2, CO and C2H2n(n=1–3). The results are analyzed in detail and show excellent agreement with recent theoretical and experimental data. The K^{-2} shake-up spectra of H2O and the C2H2n molecules are here completely characterized for the first time.
A simplistic computational procedure for the tunneling splittings caused by the proton transfer
Authors: Tikhonov Denis 
Published: February 2022

In this manuscript we present an approach for computing tunneling splittings for large amplitude motions. The core of the approach is a solution of an effective one-dimensional Schrödinger equation with an effective mass and an effective potential energy surface composed of electronic and harmonic zero-point vibrational energies of small amplitude motions in the molecule.The method has been shown to work in cases of three model motions: nitrogen inversion in ammonia, single proton transfer in malonaldehyde, and double proton transfer in the formic acid dimer. In the current work we also investigate the performance of different DFT and post-Hartree-Fock methods for prediction of the proton transfer tunneling splittings, quality of the effective Schrödinger equation parameters upon the isotopic substitution, and possibility of a complete basis set (CBS) extrapolation for the resulting tunneling splittings.
TRANSFORMASI CERITA ENDANG RARA TOMPE DALAM PERTUNJUKAN KETHEK OGLENG PACITAN
Authors: Mustofa Arif , Hendriyanto Agoes , Sutopo Bakti 
Published: February 2022

This research aims to: 1) describe the plot of Endang Roro Tompe story and Kethek Ogleng performance art; 2) describe the transformation process of Endang Roro Tompe story into Kethek Ogleng performance art. The data were collected by these four steps: 1) observing Kethek Ogleng performance art, 2) recording the video and audio of Endang Rara Tompe’s story ; 3) describing the video recording based on the performance and transcribing the audio recording of Endang Roro Tompe. The result shows that Kethek Ogleng performance art is influenced by the plot of Panji Endang Rara Tompe. However, in the whole story, the performance only takes several scenes: The monkey comes, the monkey meets Endang Rara Tompe, the monkey falls in love with Endang Rara Tompe, and the monkey leaves back to the kingdom. There are two changing patterns from Endang Rara Tompe’s hypogram into Kethek Ogleng performance art. The first change deals with the cut of scenes. Kethek Ogleng performance art only explains the end of Endang Rara Tompe’s story. The story of Jenggala Kingdom is omitted in Kethek Ogleng performance art. The second is changing the main character. The author changes the main character from Dewi Sekartaji into Panji Asmarabangun or the monkey.Penelitian ini bertujuan untuk: 1) menghasilkan deskripsi pola alur Cerita Endang Rara Tompe dan pertunjukan Kethek Ogleng; 2)menghasilkan deskripsi proses transformasi dari Cerita Endang Rara Tompe ke pertunjukan Kethek Ogleng. Data dikumpulkan dengan cara: 1) pengamatan pertunjukan Kethek Ogleng; 2) perekaman video pertunjukan Kethek Ogleng dan perekaman audio cerita Endang Rara Tompe; 3) pendeskripsian struktur pertunjukan pertunjukan; pentranskripsian hasil rekaman cerita Endang Rara Tompe. Analisi data dilakukan dengan cara 1) menyusun struktur pertunjukan (visual) Kethek Ogleng; 2) menyusun struktur cerita (lisan) Endang Rara Tompe; 3) membandingkan struktur pertunjukan (visual) Kethek Ogleng dengan struktur cerita (lisan) Endang Rara Tompe; 4) menganalisis pola perbedaan dan persamaan antara bentuk lisan dan bentuk visual. Hasil analisis menunjukkan bahwa struktur pertunjukan Kethek Ogleng dipengaruhi oleh pola alur cerita Panji Endang Rara Tompe. Namun, secara keseluruhan kisah, hanya diambil beberapa pertistiwa saja yaitu: kemunculan kera, pertemuan kera dengan Endang Rara Tompe, adegan jatuh cinta, dan adegan kembali ke kerajaan. Terdapat dua pola pemindahan dari hipogram Cerita Endang Rara Tompe ke pertunjukan Kethek Ogleng. Pertama yaitu pemotongan Adegan. Pertunjukan Kethek Ogleng hanya berisi bagian akhir dari cerita Endang Rara Tompe. Adegan kerajaan Jenggala tidak dimunculkan dalam pertujukan Kethek Ogleng. Keduaya itu alih tokoh utama. Pengarang mengubah tokoh utama dari Dewi Sekartaji menjadi Panji Asmarabangun atau tokoh kera.
PHONETIC GRAMMAR OF PLOSIVES SOUNDS SPOKEN BY SUNDANESE AND JAVANESE
Authors: Irawan Yusup , Riani NFN 
Published: February 2022

This study aims to identify “the phonetic grammar" of voiced plosive sounds [b, d, and g] and voiceless [p, t, and k] at the initial position of the words uttered by two different groups of native speakers: Sundanese and Java. These sounds are phonemically the same phonemes in Sundanese, Javanese and Indonesian. The findings show that the two groups of native speakers realize different and the same VOT (Voice Onset Time) pattern of popping sounds. For sounds voiced plosives or lenis plosive [b, d, and g], Sundanese speakers realize it with a negative VOT pattern, while Javanese speakers do it with a positive VOT pattern. Then, voiced plosive sounds uttered by Javanese speakers tend to be "aspirated" or breathy. For the voiceless plosives or fortis plosives [p, t, and k], the two groups of speakers pronounce them in the same pattern, namely the positive VOT pattern, and even tend to have zero VOT. The VOT patterns reflect aspirated voiced and voiceless phonation categories for Javanese and voiced and voiceless for Sundanese.Penelitian ini bertujuan untuk mengidentifikasi gramatika fonetik “phonetic grammar” bunyi-bunyi letupan bersuara [b, d, dan g] dan tak bersuara [p,t, dan k] pada posisi awal kata yang diucapkan oleh dua kelompok penutur jati yang berbeda: Sunda dan Jawa. Bunyi-bunyi itu secara fonemik merupakan fonem yang sama dalam bahasa Sunda, Jawa, dan Indonesia. Temuan dalam penelitian ini adalah kedua kelompok penutur jati merealisasikan pola VOT (voice onset time) bunyi letupan yang berbeda dan sama. Untuk bunyi-bunyi bersuara plosive lenis [b, d, dan g] penutur bahasa Sunda merealisasikannya dengan pola VOT negatif, sedangkan penutur bahasa Jawa merealisasikannya dengan pola VOT positif. Kemudian bunyi-bunyi letupan bersuara yang diucapkan oleh penutur bahasa Jawa cenderung “beraspirasi” atau breathy. Pada bunyi-bunyi takbersuara atau plosive fortis [p, t, dan k], kedua kelompok penutur mengucapkannya dengan pola yang sama, yakni pola VOT positif bahkan cenderung ber-VOT nol atau zero. Pola-pola VOT itu merefleksikan kategori fonasi bersuara breathy dan takbesuara untuk bahasa Jawa dan bersuara dan tak bersuara untuk bahasa Sunda.