bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multifunctional Photoacoustic/Fluorescence Dual‐Mode‐Imaging Gold‐Based Theranostic Nanoformulation without External Laser Limitations
Authors: Zhang Junfeng , Yin Xiaofeng , Li Chenchen , Yin Xuelian , Xue Qianghua , Ding Lin , Ju Jiale , Ma Jifei , Zhu Ying , Du Dongshu , Reis Rui L. , Wang, Yanli 
Published: March 2022

AbstractTheranostics is a new type of biomedical technology that organically combines the diagnosis and therapy of diseases. Among molecular imaging techniques, the integration of photoacoustic (PA) and fluorescence (FL) imaging modes with high sensitivity and imaging depth provides precise diagnostic outcomes. Gold nanorods (Au NRs) are well‐known contrast agents for PA imaging and photothermal therapy. However, their high toxicity, poor biocompatibility, rapid clearance, and the need for an external laser source limit their application. Therefore, modification of Au NRs with carbon‐based nanomaterials (CBNs) is done to obtain a multifunctional dual‐mode gold‐based nanoformulation (mdGC), which preforms dual‐mode imaging of PA and FL. The results show that mdGC promotes tumor cell apoptosis and exhibits good antitumor performance through the mitochondria‐mediated apoptotic pathway by increasing the production of intracellular reactive oxygen species, reducing mitochondrial membrane potential, and regulating the expression of apoptosis‐related genes. The targeting rate of mdGC to tumor tissue is up to 20.71 ± 1.94% ID g‐1; the tumor growth inhibition rate is as high as 80.44% without external laser sources. In general, mdGC is a potential multifunctional diagnostic and therapy integrated nanoformulation.
Correction of Aberrations via Polarization in Single Layer Metalenses
Authors: Martins Augusto , Li Kezheng , Arruda Guilherme S. , Conteduca Donato , Liang Haowen , Li Juntao , Borges Ben‐Hur V. , Krauss Thomas F. , Martins Emiliano R. 
Published: March 2022

AbstractThe correction of multiple aberrations in an optical system requires different optical elements, which increases its cost and complexity. Metasurfaces hold great promise to providing new functionality for miniaturized and low‐cost optical systems. A key advantage over their bulk counterparts is the metasurface's ability to respond to the polarization of light, which adds a new degree of freedom to the optical design. Here, it is shown that polarization control enables a form‐birefringent metalens to correct for both spherical and off‐axis aberrations using a single element only, which is not possible with bulk optics. The metalens encodes two phase profiles onto the same surface, thus allowing switching from high resolution to wide field of view operation. Such ability to obtain both high resolution and wide field of view in a single layer is an important step towards integration of miniaturized optical systems, which may find many applications, e.g., in microscopy and endoscopy.
Three‐Component Coupling of α‐Trifluoromethyl Carbonyls, Azides and Amines for the Regioselective Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazoles
Authors: Gao Ge , Kuantao  , Mao  , Lv Leiyang , Li Zhiping 
Published: March 2022

AbstractA metal‐free three‐component coupling of α‐CF3 carbonyls, azides and amines for the regioselective synthesis of 1,4,5‐trisubstituted 1,2,3‐triazoles in the air is established. Various substituted 4‐amide 1,2,3‐triazoles were obtained when the enolizable α‐CF3 ketones were applied in aqueous reaction medium. Control and 18O‐labelling experiments revealed that the in situ generated β‐oxo amide was responsible for the formal oxygen‐shift and the subsequent [3+2] cycloaddition reaction, with amine as both the catalyst and reactant. In the case of non‐enolizable α‐CF3 esters, the densely functionalized 5‐amino 1,2,3‐triazoles were achieved exclusively, which could enable the late‐stage functionalization of complex biological molecules.magnified image
Continuous Additive Manufacturing using Olefin Metathesis
Authors: Foster Jeffrey C. , Cook Adam W. , Monk Nicolas T. , Jones Brad H. , Appelhans Leah N. , Redline Erica M. , Leguizamon Samuel C. 
Published: March 2022

AbstractThe development of chemistry is reported to implement selective dual‐wavelength olefin metathesis polymerization for continuous additive manufacturing (AM). A resin formulation based on dicyclopentadiene is produced using a latent olefin metathesis catalyst, various photosensitizers (PSs) and photobase generators (PBGs) to achieve efficient initiation at one wavelength (e.g., blue light) and fast catalyst decomposition and polymerization deactivation at a second (e.g., UV‐light). This process enables 2D stereolithographic (SLA) printing, either using photomasks or patterned, collimated light. Importantly, the same process is readily adapted for 3D continuous AM, with printing rates of 36 mm h–1 for patterned light and up to 180 mm h–1 using un‐patterned, high intensity light.
Luminescent High‐Mobility 2D Organic Semiconductor Single Crystals
Authors: Fedorenko Roman S. , Kuevda Alexey V. , Trukhanov Vasiliy A. , Konstantinov Vladislav G. , Sosorev Andrey Yu. , Sonina Alina A. , Kazantsev Maxim S. , Surin Nikolay M. , Grigorian Souren , Borshchev Oleg V. , Ponomarenko Sergey A. , Paraschuk Dmitry Yu. 
Published: March 2022

Abstract2D organic semiconductor single crystals comprising one or a few molecular layers of macroscopic lateral sizes are ideal materials for ultrathin, flexible, and transparent field‐effect devices—a platform for transistors and sensors. In recent years, these 2D materials have demonstrated high performance not inferior to their 3D counterparts. However, light emissive properties of 2D organic semiconductor single crystals have not yet been reported, and a combination of high charge‐carrier mobility and bright luminescence in one material is still a challenge for 2D organic optoelectronics. Emissive high‐mobility 2D organic semiconductor based on a [1]benzothieno[3,2‐b]benzothiophene (BTBT)‐derivative, 2,7‐bis(4‐decylphenyl)[1]benzothieno[3,2‐b][1]benzothiophene (DPBTBT), is presented here. DPBTBT molecules self‐organize in large‐area ultrathin single‐crystalline films consisting of one or a few molecular layers. These 2D single crystals perfectly suit as an active layer of organic field‐effect transistors in full accordance with Shockley's model and uniquely combine the high charge‐carrier mobility reaching 7.5 cm2 V–1 s–1 with prominent light emissive properties, which allow a demonstration of the first 2D organic light‐emitting transistor. The high charge‐carrier mobility and thermal stability of the crystalline phases, pronounced luminescence, and good shelf‐life stability suggest that emissive BTBT‐type molecules are a promising avenue for 2D organic optoelectronics.
Community‐led digital literacy training: Toward a conceptual framework
Authors: Detlor Brian , Julien Heidi , La Rose Tara , Serenko Alexander 
Published: March 2022

AbstractAn exploratory study investigated the factors affecting digital literacy training offered by local community organizations, such as public libraries. Theory based on the educational assessment and information literacy instruction literatures, community informatics, and situated learning theory served as a lens of investigation. Case studies of two public libraries and five other local community organizations were carried out. Data collection comprised: one‐on‐one interviews with administrators, instructors, and community members who received training; analysis of training documents; observations of training sessions; and a survey administered to clients who participated in these training sessions. Data analysis yielded the generation of a holistic conceptual framework. The framework identifies salient factors of the learning environment and program components that affect learning outcomes arising from digital literacy training led by local community organizations. Theoretical propositions are made. Member checks confirmed the validity of the study's findings. Results are compared to prior theory. Recommendations for practice highlight the need to organize and train staff, acquire sustainable funding, reach marginalized populations, offer convenient training times to end‐users, better market the training, share and adopt best practices, and better collect and analyze program performance measurement data. Implications for future research also are identified.
Extended alone and ignore assessments: A novel examination of factors that influence determination of an automatic function
Authors: Bottini Summer , Stremel J. Meredith , Scheithauer Mindy , Morton Hannah E. 
Published: March 2022

AbstractWhen targeted behaviors are hypothesized to be automatically maintained, an extended assessment is often necessary to evaluate the impact of social contingencies and guide intervention selection. Elements that may be related to determining assessment outcome include observed characteristics of the behavior, type of sessions conducted, and the topography of targeted behavior. The present retrospective chart review analyzed these variables in 51 clients with developmental disabilities who were exposed to extended alone or ignore evaluations as part of a clinical admission. Findings indicate clinicians may conduct more sessions during extended assessments than previously reported. Level of behavior and pica as the presenting topography primarily drove determination of an automatic function. Session type and other topographies were not statistical predictors of assessment outcome. We discuss these findings with respect to balancing internal and social validity. We also present exploratory and statistically derived cut offs to consider when assessment length is constrained.
Understanding the effects of aerodynamic and hydrodynamic shear forces on Pseudomonas aeruginosa biofilm growth
Authors: Zhang Ye , Silva Dina M. , Young Paul , Traini Daniela , Li Ming , Ong Hui Xin , Cheng Shaokoon 
Published: March 2022

AbstractBiofilms are communities of bacterial cells encased in a self‐produced polymeric matrix and exhibit high tolerance towards environmental stress. Despite the plethora of research on biofilms, most biofilm models are produced using mono‐interface culture in static flow conditions, and knowledge of the effects of interfaces and mechanical forces on biofilm development remains fragmentary. This study elucidated the effects of air–liquid (ALI) or liquid–liquid (LLI) interfaces and mechanical shear forces induced by airflow and hydrodynamic flow on biofilm growing using a custom‐designed dual‐channel microfluidic platform. Results from this study showed that comparing biofilms developed under continuous nutrient supply and shear stresses free condition to those developed with limited nutrient supply, ALI biofilms were four times thicker, 60% less permeable, and 100 times more resistant to antibiotics, while LLI biofilms were two times thicker, 20% less permeable, and 100 times more resistant to antibiotics. Subjecting the biofilms to mechanical shear stresses affected the biofilm structure across the biofilm thickness significantly, resulting in generally thinner and denser biofilm compared to their controlled biofilm cultured in the absence of shear stresses, and the ALI and LLI biofilm's morphology was vastly different. Biofilms developed under hydrodynamic shear stress also showed increased antibiotic resistance. These findings highlight the importance of investigating biofilm growth and its mechanisms in realistic environmental conditions and demonstrate a feasible approach to undertake this study using a novel platform.
Cyclic l‐lactide synthesis from lignocellulose biomass by biorefining with complete inhibitor removal and highly simultaneous sugars assimilation
Authors: He Niling , Jia Jia , Qiu Zhongyang , Fang Chun , Lidén Gunnar , Liu Xiucai , Bao Jie 
Published: March 2022

AbstractCyclic chiral lactide is the monomer chemical for polymerization of high molecular weight polylactic acid (PLA). The synthesis of cyclic l‐lactide starts from poly‐condensation of
l‐lactic acid to a low molecular weight prepolymer and then depolymerized to cyclic
l‐lactide. Lignocellulose biomass is the most promising carbohydrate feedstock for lactic acid production, but the synthesis of cyclic
l‐lactide from
l‐lactic acid produced from lignocellulose has so far not been successful. The major barriers are the impurities of residual sugars and inhibitors in the crude cellulosic
l‐lactic acid product. Here we show a successful cyclic
l‐lactide synthesis from cellulosic
l‐lactic acid by lignocellulose biorefining with complete inhibitor removal and coordinated sugars assimilation. The removal of inhibitors from lignocellulose pretreatment was accomplished by biodetoxification using a unique fungus Amorphotheca resinae ZN1. The nonglucose sugars were completely and simultaneously assimilated at the same rate with glucose by the engineered
l‐lactic acid bacterium Pediococcus acidilactici. The
l‐lactic acid production from wheat straw was comparable to that from corn starch with high optical pure (99.6%), high
l‐lactic acid titer (129.4 g/L), minor residual total sugars (~2.2 g/L), and inhibitors free. The cyclic
l‐lactide was successfully synthesized from the regularly purified
l‐lactic acid and verified by detailed characterizations. This study paves the technical foundation of carbon‐neutral production of biodegradable PLA from lignocellulose biomass.
Green human resource management practices and millennial employees' retention in small and medium enterprises: The moderating impact of creativity climate from a developing country perspective
Authors: Islam Md Asadul , Mendy John , Haque A. K. M. Ahasanul , Rahman Mahfuzur 
Published: March 2022

AbstractDrawing on social exchange theory (SET), this paper examines the gap in the application of green human resource management practices and its effectiveness on millennial employees' retention. This study employed quantitative analysis based on surveys using a sample of 389 respondents from different small and medium enterprises (SMEs) located in the Dhaka Division of Bangladesh. The results show a positive relationship between green training and development and green reward and millennial employees' retention. However, the results show a negative relationship between green recruitment and selection, green involvement, green performance management and millennial employees' retention. Additionally, we found that applying green training and development and green reward are most beneficial both individually and organisationally. This study's contribution to SET is referred to as ‘green creativity climate’ as we have found it to be a significant moderator that helps business leaders and HR practitioners understand which green practices are most effective in retaining the services of an elusive part of the workforce such as millennial employees. Our proposed model highlights how a green creativity climate can foster a new social exchange bond between SMEs and millennials and thereby mitigate against the resource difficulties and performance deficits partly triggered by millennial turnovers.
Smad4 and p53 synergize in suppressing autochthonous intestinal cancer
Authors: Park Jun Won , Seo Min‐Jung , Cho Kye Soo , Kook Myeong‐Cherl , Jeong Jong Min , Roh Seul‐Gi , Cho Soo Young , Cheon Jae Hee , Kim Hark Kyun 
Published: March 2022

AbstractBackgroundSmad4 and p53 mutations are the most common mutations in human colorectal cancers (CRCs). We evaluated whether and how they are synergistic in intestinal carcinogenesis using novel autochthonous mouse models.MethodTo recapitulate human CRCs, we generated Villin‐Cre;Smad4F/F;Trp53F/F mice. We then compared the intestinal phenotype of Villin‐Cre;Smad4F/F;Trp53F/F mice (n = 40) with Villin‐Cre;Smad4F/F (n = 30) and Villin‐Cre;Trp53F/F mice (n = 45).ResultsTwenty‐week‐old Villin‐Cre;Smad4F/F;Trp53F/F mice displayed spontaneous highly proliferative intestinal tumors, and 85% of mice developed adenocarcinomas. p21 was downregulated in the intestinal mucosa in Villin‐Cre;Smad4F/F;Trp53F/F mice than in Villin‐Cre;Smad4F/F and Villin‐Cre;Trp53F/F mice. Villin‐Cre;Smad4F/F;Trp53F/F mice displayed multistep intestinal tumorigenesis and Wnt activation. Long‐term CWP232291 (small‐molecule Wnt inhibitor) treatment of Villin‐Cre;Smad4F/F;Trp53F/F mice suppressed intestinal tumorigenesis and progression. CWP232291 treatment downregulated cancer stem cell (CSC) tumor markers including CD133, Lgr‐5, and Sca‐1. CWP232291 treatment reduced the CSC frequency. Small‐molecule Wnt inhibitors reduced intestinal CSC populations and inhibited their growth, along with Bcl‐XL downregulation. Furthermore, BH3I‐1, a Bcl‐XL antagonist, increasingly inhibited intestinal CSCs than bulk tumor cells.ConclusionSmad4 loss and p53 loss are synergistic in autochthonous intestinal carcinogenesis, by downregulating p21 and activating Wnt/β‐catenin pathway.
The prognostic effect of residual tumor for advanced epithelial ovarian cancer treated with neoadjuvant chemotherapy or primary debulking surgery
Authors: Yang Shi‐Ping , Chen Jian‐Xian , Xu Jing‐Ying , Lei Jian , Wu San‐Gang , Zhou Juan 
Published: March 2022

AbstractPurposeThe role of neoadjuvant chemotherapy (NACT) and primary debulking surgery (PDS) in advanced epithelial ovarian cancer (EOC) remains controversial. This study aimed to investigate the prognosis between NACT and PDS in advanced EOC. We also investigated the prognostic effect of the residual tumor (RT) after NACT and PDS.MethodsPatients with stage III‐IV EOC diagnosed between 2010 and 2017 were included from the Surveillance, Epidemiology, and End Results (SEER) database. Chi‐square test, multivariate logistic regression analysis, Kaplan–Meier curves, and Cox proportional hazards model were used for statistical analyses.ResultsA total of 5522 women patients were identified, 2017 (36.5%) and 3505 (63.5%) patients received NACT and PDS, respectively. There were 2971 (53.8%), 1637 (29.6%), and 914 (16.6%) patients who had no residual tumor, RT ≤1 cm, and RT >1 cm, respectively. There were 25.5% of patients receiving NACT in 2010 and 48.4% in 2017 (p < 0.001). Women treated with NACT were not related to a higher chance of complete resection than the PDS group (p = 0.098). Patients receiving PDS had significantly better cancer‐specific survival (CSS) than those receiving NACT (p < 0.001). The 5‐year CSS was 35.3% and 51.1% in those receiving NACT and PDS, respectively. In patients receiving NACT, those who had no residual tumor had significantly better CSS compared to those who had RT ≤1 cm (p < 0.001), while comparable CSS was found between those who had RT ≤1 cm and RT >1 cm (p = 0.442). In those receiving PDS, the CSS was decreased with a RT increase (p < 0.001).ConclusionsOur study suggests that PDS may be the optimal procedure for the majority of advanced EOC patients. Complete resection of all residual diseases should be the goal with the increased utilization of NACT.
Novel N‐(1H‐Pyrazol‐5‐yl)nicotinamide Derivatives: Design, Synthesis and Antifungal Activity
Authors: Wang Wei , Liu Xiang‐Jia , Lin Guo‐Tai , Wu Ji‐Peng , Xu Gong , Xu Dan 
Published: March 2022

AbstractTo discover more effective antifungal agents, twenty N‐(1H‐pyrazol‐5‐yl)nicotinamide derivatives were designed, synthesized, and structurally confirmed by 1H‐NMR, 13C‐NMR, and ESI‐MS. All target compounds were evaluated for their antifungal activities by mycelia growth inhibition. Preliminary screening results displayed that many of these compounds had good fungicidal activity to S. sclerotiorum and V. mali. Compound B4 exhibited antifungal activity against S. sclerotiorum and V. mali with EC50 values of 10.35 and 17.01 mg/L, respectively. The experiment in vivo identified that compound B4 was effective for suppressing rape sclerotinia rot caused by S. sclerotiorum at 50 mg/L. The molecular docking study and scanning electron microscopy preliminary clarified the possible antifungal mechanism of compound B4.
Inferior epigastric artery pseudoaneurysm following abdominal paracentesis in a patient with chronic kidney failure: A case report and review of literature
Authors: Kian Behnam , Teimouri Arash 
Published: March 2022

AbstractInferior epigastric artery (IEA) pseudoaneurysm is a rare complication following abdominal wall procedures near the artery. This is a case of inferior epigastric artery pseudoaneurysm after therapeutic paracentesis for large‐volume ascites caused by chronic kidney failure. The patient was operated on, and the artery was ligated.
Efficacy of metacognitive training for depression as add‐on intervention for patients with depression in acute intensive psychiatric inpatient care: A randomized controlled trial
Authors: Hauschildt Marit , Arlt Sönke , Moritz Steffen , Yassari Amir H. , Jelinek Lena 
Published: March 2022

AbstractBackgroundMetacognitive training for depression (D‐MCT) is a novel low‐intensity group training for economic treatment of depression. Previous studies demonstrate its efficacy in moderately depressed outpatients. The present study evaluated efficacy and patients' perspective of the D‐MCT in severely depressed psychiatric inpatients.MethodsIn a randomized‐controlled trial, 75 individuals with a major depressive disorder (MDD) were allocated to D‐MCT versus euthymic therapy as add‐on (twice a week) to cognitive‐behavioural‐based (CBT) inpatient‐care. Depressive symptoms (HDRS, BDI), dysfunctional (meta)cognition (DAS, MCQ‐30) and subjective appraisal were assessed at baseline, 4 weeks (post) and 3 months (follow‐up).ResultsParticipants in both conditions showed a large decline in depression at post and follow‐up‐assessment. No superior add‐effect of D‐MCT versus active control emerged for depression severity on top of the inpatient care. However, among patients with a diagnosis of MDD with no (vs. at least one) comorbidity, D‐MCT participants showed a larger decline in depressive (meta‐)cognition at follow‐up with medium‐to‐large effect sizes. D‐MCT was evaluated as superior in overall appraisal, treatment preference, motivation and satisfaction.LimitationsThe follow‐up time interval of 3 months may have been too short to detect long‐term effects. There is emerging evidence that modification of (meta)cognition unfolds its full effects only with time. Effects of CBT inpatient‐care on outcome parameters cannot be differentiated.ConclusionsAlthough D‐MCT as an add‐on was not superior in complete case analyses, results suggest greater benefit for patients with MDD and no comorbidity. D‐MCT proved feasible in acute‐psychiatric inpatient‐care and was highly accepted by patients. Future studies should investigate the role of modified (meta)cognition on long‐term treatment outcome, including dropout and relapse rates.
Long noncoding RNA polymorphisms and colorectal cancer risk: Progression and future perspectives
Authors: Abdi Esmat , Latifi‐Navid Saeid , Latifi‐Navid Hamid 
Published: March 2022

AbstractColorectal cancer (CRC) is one of the most common cancers causing death worldwide. Many long noncoding RNAs (lncRNAs) have possible carcinogenic or tumor suppressor functions. Some lncRNA polymorphisms are useful for predicting cancer risk, and may help advance personalized therapy management. While the use of lncRNAs as biomarkers is promising, there are still drawbacks, and further studies are needed to verify the consistency of current outcomes in large‐scale populations and different ethnicities. Single nucleotide polymorphisms (SNPs) can disrupt a lncRNAs' function, thus enhancing or hindering disease occurrence. SNPs can directly influence the lncRNA expression by interfering with transcription factor binding or affecting indirectly a regulatory factors' expression. Moreover, the association between lncRNAs and other RNAs or proteins may be disrupted by SNPs. This research sought to assess the association between lncRNA polymorphisms and CRC risk, as well as clinical and therapeutic consequences in certain cases.