bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alveolar epithelial cells are competent producers of interstitial extracellular matrix with disease relevant plasticity in a human in vitro 3D model
Authors: Rosmark Oskar , Kadefors Måns , Dellgren Göran , Karlsson Christofer , Ericsson Anders , Lindstedt Sandra , Malmström Johan , Hallgren Oskar , Larsson-Callerfelt Anna-Karin , Westergren-Thorsson Gunilla 
Published: November 2022

Abstract
Background
The structure of alveoli is critical for normal lung function and when maintenance of the underlying extracellular matrix (ECM) that forms these delicate structures fails, patients may develop emphysema or lung fibrosis via pathological processes that are not fully understood. The alveolar walls are lined by alveolar epithelial cells (AEC), these cells have so far been implicated in pathological remodeling through signaling that alters the activity of mesenchymal and immune cells. We set out to examine the capacity of AEC to produce ECM and thereby directly contribute towards the ECM remodeling in chronic lung diseases.
Methods
Cryopreserved type 2 AEC (AEC2) isolated from healthy lungs and chronic obstructive pulmonary disease (COPD) afflicted lungs were cultured in decellularized human lung slices over a period of 13 days. AEC2 from healthy lungs were treated with transforming growth factor ß1 (TGF-β1) to evaluate the plasticity of their ECM production. Evaluation of phenotypic markers and expression of matrisome genes and proteins were performed by RNA-sequencing, mass spectrometry and immunohistochemistry.
Results
AEC2 in our model displayed an AEC marker profile similar to freshly isolated AEC2 throughout the 13 day culture period. Cultured COPD-derived AEC2 retained expression of known disease markers, as HLA-A. AEC2 expressed basement membrane components but also a complex set of structural proteins found in interstitial ECM. TGF-β1 stimuli of AEC2 from healthy lungs induced a change in ECM production from AEC2 resembling what has previously been documented in mesenchymal cells, without loss of specific AEC marker expression.
Conclusions
This study reveals a previously unexplored potential of AEC to directly contribute to ECM turnover, motivating a re-evaluation of the role of AEC2 in pathological lung remodeling.
Cosine-type apodized spiral zone plate to handle the topological charge of a vortex beam
Authors: Balanoji Seyyed Mojtaba Taheri , Sabatyan Arash , Rishakani Behnaz Javidi 
Published: November 2022

Abstract
By taking advantage of spiral petal-like zone plates, we have recently demonstrated that a spiral element's geometric shape impacts its charge. Keeping it in mind, we aim to control topological charge of a vortex by means of phase modification of an spiral zone plate without transforming its geometrical shape. This is achieved by apodizing a spiral zone plate having p spiral zones with a radial grating with spatial frequency m. Having implemented some radial gratings with different m, we realized that an optical vortex is produced whose topological charge and its handedness are dependent on p and m. Consequently, a constant phase replaces on-axis screw dislocation under the situation that p takes an odd multiples of m. Studies are carried out for both large and small pairs of (p,m) and various gaps between the couple.
Strain measurement method based on external symmetrical compensation bridge composed of strain gauges with four-wire configuration for a large- scale NbTi superconducting dipole magnet detector
Authors: Zhang Yongjie , Xin Canjie , Gao Peifeng , He Tianhu , Guan Mingzhi 
Published: November 2022

Abstract
In this study, we present a strain measurement method based on an external symmetrical compensation bridge (ESCB) composed of strain gauges with a four-wire configuration. Unlike the traditional strain measurement methods, this method includes two features: first, utilising the four-wire configuration to eliminate measurement errors that occur due to large space-varying thermal and field imbalances of long signal wires during operation, and second, utilising two independent quarter-active sub-bridges with a four-wire configuration composed of ESCB to eliminate the errors that occur due to the large time-varying cryogenic temperature and magnetic field. This method was used on a large-scale NbTi superconducting dipole magnet detector during the cooling, excitation, and quench tests. The strains measured using the ESCB were compared with those measured using a traditional half-active compensation bridge. The results indicated that the new method can accurately detect the strain features of a large-scale superconducting magnet. In addition, using the proposed method, spectrum analysis of strain measurements was implemented during excitation, quench onset, and post-quench. A larger amplitude at a higher frequency was clearly observed at the onset of a quench than that observed during excitation and post-quench. Thus, the dynamic strain characteristics of a superconducting magnet structure could be a candidate for predicting the quench.
Ternary blends of thermoplastic starch (TPS) with poly(lactic acid) (PLA) and poly(butylene succinate- co-adipate) (PBSA): design, processing and characterization of home compostable materials
Authors: Gisario A. , Aversa C. , Barletta M. , Cappiello G. , Koça N. 
Published: November 2022

Abstract
This paper studies ternary blends of thermoplastic starch (TPS) with bio-derived polyesters, such as polylactic acid (PLA) and polybutylene succinate-co-adipate (PBSA). The compounds were obtained by means of a co-rotating twin screw extruder and were then reprocessed by cast extrusion and thermoforming in order to obtain, respectively, films and semi-rigid containers. Semi-finished products (compounds and films) and thermoformed products were characterized to evaluate their thermo-mechanical, physical and chemical properties. The films showed good mechanical strength, adequate stiffness / toughness compromise and fair impermeability to oxygen. Furthermore, experimental tests have shown a high disintegration rate of the designed material with considerable mass loss in ambient composting conditions. On the other hand, the thermoformed containers showed inadequate thermal resistance, failing to endure direct contact with hot liquids at 100 ° C.
Efficacy of ex vivo Purging with CD34+ Selection to Maximize the Effects of Autologous Stem Cell Transplantation in Peripheral T-cell Lymphoma Patients
Authors: Jeon Youngwoo , Woo Weon-Mu , Kim Tong-Yoon , Min Gi June , Park Sung-Soo , Park Silvia , Yoon Jae-Ho , Lee Sung-Eun , Cho Byung-Sik , Eom Ki-Seong , Kim Yoo-Jin , Kim Hee-Je , Lee Seok , Min Chang-Ki , Lee Jong-Wook , Cho Seok-Goo 
Published: November 2022

Abstract
Background: Autologous stem cell transplantation (ASCT) is the standard treatment for peripheral T-cell lymphomas (PTCLs). Strategies that reduce the relapse rate and treatment-related mortality are essential for successful ASCT. Because in vivo/in vitro purging methods using rituximab are not appropriate for T-cell lymphomas, an ex vivo CD34+ selective purging system is the most reliable method to reduce autograft tumor cell contamination in these tumors.
Methods: We retrospectively investigated the influence of ex vivopurging with CD34+ selection to maximize the effects of ASCT. Of 67 consecutive PTCL patients, 32 and 35 underwent purged and unpurged ASCT.
Results: The purged group had improved overall survival (OS), disease-free survival (DFS), and cumulative incidence of relapse (hazard ratio [HR] = 2.68, p = 0.016; HR = 3.97, p = 0.002; and HR = 3.65, p = 0.004, respectively), compared to the unpurged group. Prognostic factor analysis showed that unpurged ASCT, chromosomal abnormalities at initial diagnosis, high risk, and pre-ASCT disease status were associated with poor survival outcomes. Subgroup analysis demonstrated that purging was most appropriate for International Prognostic Index high-risk patients who underwent upfront ASCT (HR = 3.35 [OS] and = 6.59 [DFS]). In purged ASCT group, NK cell activity and the lymphocyte-to-monocyte ratio known as an independent prognostic factor were increased after ASCT with statistical significance.
Conclusions: There were no engraftment failures or differences in adverse events between the two groups. CD34+ ex vivo purging ASCT is safe, effective, and may improve survival outcomes, particularly in high-risk PTCL patients.
Cognitive-adaptive functioning gap and mediating factors impact on adaptive functioning in preschool-aged children with autism spectrum disorder
Authors: Wang Shi-huan , Zhou Qing , Chen Kai-yun , Ceng Chao-qun , Zhan Guo-dong , You Cong , Xing Yu , Zou Yuan-Yuan , Deng Hong-zhu 
Published: November 2022

Abstract
Background Few studies have focused on cognitive-adaptive functioning gap in autism spectrum disorder (ASD), and how mediating factors impact on adaptive functioning remains undefined. This study aims to investigate the gap between cognitive functioning and adaptive functioning in preschool-aged children with ASD. Mediating factors of cognitive functioning, ASD severity, early development and socioeconomic factorsare systematically explored to determine adaptive functioning.
Methods A total of 151 children with ASD were enrolled, aged 2.5-6 years. Adaptive Behavior Assessment System Version II，Wechsler Preschool and Primary Scale-IV, Autism Diagnostic Observation Schedule (ADOS) were respectively performed to assess adaptive functioning, cognitive functioning and ASD severity. All children were divided into two groups based on IQ: IQ≥70 group and IQ<70 group. The difference of IQ-adaptive skills gap between the two groups were explored by calibrating age, age of diagnosis and IQ. Verbal acceptation index (VAI) and nonverbal index (NVI) were distinguished to predict adaptive skills.
Results The gap between IQ and adaptive skills was significant in ASD with IQ≥70, and the differences in VIA and NVI were still statistically significant (all P<0.001). VIA was positively association with overall adaptive skills and specific domain, whereas NVI had no significant correlations with adaptive skills. Despite ADOS-Calibrated severity scores were negatively correlated with social and practical skills, the scores accounted for no significant variance. Age of first walking unaided was positively correlation with adaptive skills and specific domain (all P<0.05).
ConclusionsThe IQ-adaptive functioning gap is significant in ASD with IQ≥70, suggesting that "high functioning autism" is not an appropriate description merely on account of IQ. Verbal IQ is a specific factor to predict adaptive functioning of ASD; The severity of ASD symptoms have no significant contribution to predict adaptive functioning; Early signs of motor development may be a predictor to adaptive functioning in preschool-aged children with ASD.
Native liver survivors of portoenterostomy for biliary atresia with excellent outcome. Redefining “successful” portoenterostomy
Authors: Tsuboi Koichi , Watayo Hiroko , Tsukui Takafumi , Suda Kazuto , Abe Eri , Fujimoto Takamori , Ochi Takanori , Lane Geoffrey J. , Koga Hiroyuki , Yamataka Atsuyuki 
Published: November 2022

Abstract
Purpose:
Native liver survivors (NLS) after portoenterostomy (PE) for biliary atresia (BA) with normal biomarkers defined as total bilirubin (T-Bil), aspartate aminotransferase (AST)/alanine aminotransferase (ALT) for liver function (LF), cholinesterase (ChE), platelet count (PC), and absence of portal hypertension (PHT) were reviewed to redefine “successful” PE.
Methods:
92 post-PE BA patients were classified as NLS-1: normal biomarkers, PHT (-); NLS-2: at least one abnormal biomarker, PHT (-); NLS-3: normal biomarkers, PHT (+); NLS-4: abnormal biomarkers, PHT (+) and reviewed for a maximum 32 years.
Results:
As of June 2022, 55/92 (59.8%) had received liver transplants and 37/92 (40.2%) were NLS. NLS patients were classified as excellent outcome (EO): NLS-1 (n=10; 27.0%) or non-EO: NLS-2: (n=8; 21.6%), NLS-3: (n=6; 16.2%), and NLS-4: (n=13; 35.1%). Compared with non-EO, EO had PE earlier (50.5 versus 65 days; not significant; p=0.08), significantly earlier onset of symptoms (13 days versus 32 days; p=0.01) and significantly shorter jaundice-clearance (JC; 34.5 days versus 56.0 days; p<0.001). Durations of follow-up were similar: 13 years in EO, 18.5 years in NLS-2, 20 years in NLS-3, and 15 years in NLS-4.
Conclusions:
Incidence of “successful” PE or EO is low and correlated with early onset of symptoms and quicker JC.
Influence of defects in sp2-bonded network of diamond-like carbon on silica scale adhesion in geothermal power plants
Authors: Nakashima Yuya , Umehara Noritsugu , Kousaka Hiroyuki , Tokoroyama Takayuki , Murashima Motoyuki , Murakami Kohei 
Published: November 2022

Abstract
Silica scale adhesion onto geothermal power plant equipment reduces the power efficiency. In our previous study, diamond-like carbon (DLC) coatings with low sp2 fractions and high hydrogen contents were found to suppress silica adhesion. Therefore, the present study was aimed at clarifying the mechanism of silica adhesion onto the sp2-bonded network of DLC. In-lens scanning electron microscopic imaging of silica adhered onto defective graphene indicated that the adhesion occurred on defects in the sp2-bonded network. First-principles calculations revealed that the graphene with hydrogen-terminated defects exhibited reduced adsorption energy between silica and the sp2-bonded network. Overall, the simulations and experiments helped establish a silica adhesion model in which defects in the sp2-bonding network of DLC behave as silica adhesion sites
Effects of PM 2.5 exposure on metabolic dysfunction during pregnancy via personalized measurement of pollutant concentration in South Korea: A multicenter prospective cohort, air pollution on pregnancy outcome (APPO) study
Authors: Jeong Yeonseong , Park Sunwha , Kwon Eunjin , Hur Young Min , You Young-Ah , Kim Soo Jung , Lee Gain , Lee Kyung A , Cho Geum Joon , Oh Min-Jeong , Na Sung Hun , Kim Soo Min , Lee Se jin , Bae Jin-Gon , Kim Yu-Hwan , Lee Soo-Jeong , Kim Na Kyung , Kim Young-Han , Kim Young Ju 
Published: November 2022

Abstract
Background
Ambient particulate matter (PM) is a trigger factor for metabolic dysfunction. This study aimed to evaluate the associations between PM exposure and metabolic dysfunction in pregnancy.
Methods
This prospective, multicentre, observational, cohort study was conducted from January 2021 to June 2022. A total of 333 women with singleton pregnancies were recruited. For individual measurement of PM2.5 levels, an AirguardK® was installed inside the participants’ houses. Time-activity logs were recorded to predict each participant’s personal exposure to PM2.5. The participants were divided into groups according to the concentration of PM2.5 calculated by a time-weighted average model. We used the Student t-test and chi-squared test (or Fisher’s exact test) to evaluate changes in metabolic compound levels, blood pressure (BP), glucose intolerance, and lipid profiles, including serum triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratios. Logistic and linear regression models were used to analyse the association between PM2.5 exposure and metabolic dysfunction, using odds ratios (ORs) and 95% confidence intervals (CIs).
Results
PM2.5 exposure during pregnancy worsened metabolic dysfunction. Third trimester BP was elevated in those participants exposed to higher levels of PM2.5 (p <0.05). The incidence of gestational diabetes mellitus (GDM) was constantly higher in those exposed to more PM2.5, regardless of the PM2.5 cut-off level (PM2.5 ≥10 µg/m3, 7.91 % vs. 16.09 %, p <0.05; PM2.5 ≥25 µg/m3, 7.91 % vs. 26.67 %, p <0.05). The proportion with a TG/HDL-C ratio ≥3.0 was significantly higher when PM2.5 was ≥10 µg/m3 (75.3 % vs. 83.0 %, p <0.05). Triglyceride levels were significantly higher in the PM2.5 ≥25 µg/m3 group (p=0.0171). We found an increased risk of elevated BP (adjusted OR [aOR]: 2.228, 95% CI: 1.115–4.449) and GDM (aOR 2.263, 95% CI 1.106–5.039) in the third trimester after adjusting for confounders.
Conclusion
Exposure to PM2.5 worsens metabolic dysfunction in pregnancy. Further studies are required to investigate the mechanisms by which ambient PM affects metabolic dysfunction in pregnancy.
Face expression recognition based on improved MobileNeXt
Authors: Chun-man Yan , Xiang Zhang , Qingpeng Wang 
Published: November 2022

Abstract
FER(Face expression recognition) plays an important role in human-computer interaction, but it is also one of the hot problems that artificial intelligence is difficult to solve. In recent years, as researchers have intensively studied the field of FER, the number of network models applied to FER has also increased. Relying on their strong feature extraction ability, CNN(Convolutional neural networks) have gradually become the main model in the field of FER. However, the excessive amount of parameters of CNN limits its application scenarios, and the lightweight technique for CNN brings about the degradation of face expression feature extraction ability. To address the above problems, this paper proposes an improved MobileNeXt-based expression recognition network. Based on the MobileNext lightweight network , the model improves its feature extraction capability. Firstly, the SandGlass block in the network can enhance the transmission of feature information in the network and reduce the loss of expression features during transmission. Secondly, the Ghost module is used to replace the 1×1 convolution kernel in the network to reduce the number of parameters in the feature extraction layer. Then use Drop-Activation layer instead of ReLU layer in Sandglass block to enhance the generalization ability and accuracy of the network. Finally, the Spatial Group-wise Enhance attention mechanism is introduced to enhance the network's ability to refine the expression features. The experimental results show that the network model improves the expression recognition accuracy by 2.6%, 6.5% and 7.15% in FER2013, RAF-DB and CK+ datasets, respectively, while the parameter and floating-point operations only increase 0.85M and 2.93M compared with MobileNet V2.
Effect of Substrate Media on Growth, Amino, and Fatty Acid Profile of Marine Worm (Nereis virens) at Awur Bay, Jepara, Indonesia
Authors: Windarto Seto , Elfitasari Tita , Darmanto Y.S. , Anggraeni Novia , Herawati Vivi Endar 
Published: November 2022

Abstract
Marine worms (Nereis virens) are deposit feeders that utilize organic materials as food and are used as natural feed for shrimp hatcheries. The type of substrate used for the growth of Nereis virens also affects the nutritional quality. This study aims to find the best substrate media for marine worms' growth, and the amino and fatty acid profile of N. virens. The study was conducted at the Marine Science Technopark (MSTP) Undip Jepara-Central Java. Test animals were 2–3 months old marine worms, with body lengths ranging from 10–15 cm/worm and weights ranging from 0.15–0.5 g/worm. Feed twice daily and maintain a density of 45 worms/L for 45 days. The experimental method with a completely randomized design (CRD) was used, treatment A (clay mud media), B (Sand Silt media), and C (mangrove mud media). The data observed were absolute weight (Wm), Specific Growth Rate (SGR), Feed Utilization Efficiency (FUE), Feed Conversion Ratio (FCR), Protein Efficiency Ratio (PER), Survival Rate (SR), amino and fatty acid profile. The conclusion is that the mangrove mud substrate had a significant effect (P < 0.05) on Wm (6.80 ± 0.18 g), SGR (6.40 ± 0.01%), FUE (68.95 ± 2.30%), FCR (1.30 ± 0.12%), PER (1.70 ± 0.37%), and SR (97.44 ± 0.41%) of Nereis virens with 48.46 ppm of methionine and 8.15% of EPA.
Evaluation of postoperative discomfort after strabismus surgery under general anesthesia in children: a prospective observational study
Authors: Mo Yawen , Zhang Wenjuan , Tang Xiangcheng , Zhang Rui , Wang Yinghuan , Zheng Lingling 
Published: November 2022

Abstract
Introduction: Strabismus surgery is most commonly performed on children under general anesthesia. However, few studies have focused on the postoperative discomfort in children after strabismus surgery.
Methods: A single-center prospective observational study including 300 children who underwent strabismus surgery after general anesthesia was conducted. Patients’ characteristics, preoperative anxiety, surgical and anesthesia data, discomfort within 24 hours after postanesthesia care unit were recorded.
Results: Approximately 61.33% of the children complained of at least one of the following types of discomfort. Multivariate analysis indicated that history of PONV (P=0.999), history of motion sickness (P<0.001, odds ratio [OR]=3.72), and surgery in the dominant eye (P=0.010, OR=2.00) were independent predictors of postoperative discomfort; age was an independent predictor of EA (P<0.001, OR=0.33); prism diopter≥40 was an independent predictor of headache (P=0.005, OR=5.53); age (P=0.020, OR=1.12) and history of motion sickness (P=0.001, OR=2.80) were independent predictors of dizziness; history of PONV (P=0.999), history of motion sickness (P=0.001, OR=2.63), and surgery of inferior oblique anterior transposition (IOAT) (P=0.004, OR=3.10) were independent predictors of PONV.
Conclusion: Younger age, larger angle of strabismus, history of motion sickness, history of PONV, surgery on the dominant eye, and IOAT may be risk factors for postoperative discomfort.
On a Nonlocal Integral Operator Commuting with the Laplacian and the Sturm-Liouville Problem I: Low Rank Perturbations of the Operator
Authors: Hermi Lotfi , Saito Naoki 
Published: November 2022

Abstract
We reformulate all general real coupled self-adjoint boundary value problems as integral operators and show that they are all finite rank perturbations of the free space Green's function on the real line. This free space Green's function corresponds to the nonlocal boundary value problem proposed earlier by Saito [41]. These are polynomial perturbations of rank up to 4. They encapsulate in a fundamental way the corresponding boundary conditions.
EcoDataCube.eu: Analysis-ready open environmental data cube for Europe
Authors: Witjes Martijn , Parente Leandro Leal , Krizan Josip , Antonic Luka , Hengl Tomislav 
Published: November 2022

Abstract
The paper describes production steps and accuracy assessment of an analysis-ready open environmental data cube (2000--2021+) for continental Europe; at working resolutions from 10~m to 30~m and with quarterly to annual estimates. The data cube is based on processing and harmonizing earth observation (EO) images: Landsat GLAD ARD (2000- -2020+), Sentinel-2 images (2017--2021+) and Digital Elevation data. These datasets were created with accessibility, user-friendliness, interoperability and synthesis in mind. This has required systematic spatiotemporal harmonization, efficient compression, and imputation of missing values. To ensure a missing value percentage below 1%, the EO data was ûrst aggregated into 4 quarterly periods approximating the 4 seasons common in Europe (winter, spring, summer and autumn), and then split into three percentiles (25th, 50th and 75th). Remaining missing data in the Landsat time-series was imputed with a temporal moving window median (TMWM) approach. The accuracy assessment shows TMWM gap-filling achieves higher performance in Southern Europe, and lower performance in mountainous regions such as the Scandinavian Mountains, the Alps, and the Pyrenees. The intended uses of the EcoDataCube platform include vegetation, soil, land cover and land use mapping projects, environmental monitoring and automated generation of data for statistical oûces including Eurostat. Combining all four datasets produced in this work (DTM, Landsat 30m, Sentinel-2 30m and Sentinel-2 10m) yields the highest land cover classification accuracy, with different datasets improving the results for diûerent land cover classes. The Environmental data cube for Europe is available under CC-BY license as Cloud-Optimized GeoTIFFs (ca. 12TB in size) through STAC and the EcoDataCube data portal.