bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patellar Resurfacing in Primary Total Knee Arthroplasty: A Meta‐analysis and Trial Sequential Analysis of 50 Randomized Controlled Trials
Authors: Tang Xiumei , He Yue , Pu Shi , Lei Lei , Ning Ning , Shi Yu , Chen Jiali , Zhou Zongke 
Published: December 2022

ObjectiveDuring total knee arthroplasty, femur and tibia parts are regularly replaced, while resurfacing the patellar or not is an ongoing discussion. To compare revision rate, anterior knee pain rate, patient‐reported outcome measures, complication, radiographic, and clinical outcomes after patellar resurfacing versus non‐resurfacing in total knee arthroplasty.MethodsPubMed, Medline, EMBASE, CENTRAL, and CINAHL databases were searched on 25 April 2021 to enroll randomized controlled trials that compared patellar resurfacing versus non‐resurfacing. We used the grading of recommendations assessment, development and evaluation (GRADE) framework to assess the certainty of evidence. Our primary outcome was revision rate and secondary outcomes was anterior knee pain rate. Outcomes were pooled using the random‐effect model and presented as risk ratio (RR), or mean difference (MD), with 95% confidence interval (CI).ResultsFifty studies (5586 knees) were included. Significant reductions in patellar revision rate (RR 0.41, 95% CI [0.19, 0.88]; P = 0.02; I2 = 24.20%) and non‐patellar revision rate (RR 0.64, 95% CI [0.55, 0.75]; P < 0.001; I2 = 0%) were seen after patellar resurfacing. Patellar resurfacing significantly reduced the anterior knee pain rate than nonresurfacing (RR 0.72, 95% CI [0.57, 0.91]; P = 0.006; I2 = 69.5%). Significant differences in patient‐reported outcome measures were found. However, these differences were inconsistent and lacked clinical importance. Patellar resurfacing resulted in a significant lower rate of patellar clunk (RR 0.58, 95% CI [0.38, 0.88]; P = 0.01; I2 = 0%), a higher patellar score (MD 1.24, 95% CI [0.67, 0.81]; P < 0.001; I2 = 73.8%), but prolonged surgical time (MD 8.59, 95% CI [5.27, 11.91]; P < 0.001; I2 = 88.8%).ConclusionsThe clear relationship is that patellar resurfacing reduces revisions, anterior knee pain, and patellar clunk. It will be interesting to compare the initial cost with the revision cost when required and cost‐utility analysis with long‐term results in future studies.
Lead related atrial perforation mimicking inferior ST elevation myocardial infarction
Authors: Yilancioglu Reşit Yiğit , Turan Oğuzhan Ekrem , Başkurt Ahmet Anıl , Özcan Emin Evren 
Published: December 2022

AbstractST‐elevation myocardial infarction (STEMI) is a life‐threatening clinical condition that requires immediate intervention, mostly caused by complete occlusion of epicardial vessels. Other diseases such as myocarditis, pericarditis, electrolyte disturbance, and early repolarization may mimic. We present a rare case of atrial lead‐related atrial perforation which mimics inferior STEMI.
Induced pluripotent stem cells reprogramming overcomes technical limitations for highly pigmented adult melanocyte amplification and integration in 3D skin model
Authors: Cohen Catherine , Flouret Virginie , Herlyn Meenhard , Fukunaga‐Kalabis Mizuho , Li Ling , Bernerd Françoise 
Published: December 2022

AbstractUnderstanding pigmentation regulations taking into account the original skin color type is important to address pigmentary disorders. Biological models including adult melanocytes from different phenotypes allow to perform fine‐tuned explorative studies and support discovery of treatments adapted to populations' skin color. However, technical challenges arise when trying to not only isolate but also amplify melanocytes from highly pigmented adult skin. To bypass the initial isolation and growth of cutaneous melanocytes, we harvested and expanded fibroblasts from light and dark skin donors and reprogrammed them into iPSC, which were then differentiated into melanocytes. The resulting melanocyte populations displayed high purity, genomic stability, and strong proliferative capacity, the latter being a critical parameter for dark skin cells. The iPSC‐derived melanocyte strains expressed lineage‐specific markers and could be successfully integrated into reconstructed skin equivalent models, revealing pigmentation status according to the native phenotype. In both monolayer cultures and 3D skin models, the induced melanocytes demonstrated responsiveness to promelanogenic stimuli. The data demonstrate that the iPSC‐derived melanocytes with high proliferative capacity maintain their pigmentation genotype and phenotypic properties up to a proper integration into 3D skin equivalents, even for highly pigmented cells.
Diagnostic and therapeutic management of vesico‐ureteral reflux in pediatric kidney transplantation—Results of an online survey on behalf of the European Society for Paediatric Nephrology
Authors: Zirngibl Matthias , Buder Kathrin , Luithle Tobias , Tönshoff Burkhard , Weitz Marcus ,   Members of the “Transplantation Working Group” of the European Society for Paediatric Nephrology (ESPN)
Published: December 2022

AbstractBackgroundVesico‐ureteral reflux (VUR) is considered to be a risk factor for recurrent febrile urinary tract infections and impaired renal transplant survival.MethodsAn online survey supported by the European Society for Paediatric Nephrology was designed to evaluate current management strategies of VUR in native and transplanted kidneys of recipients aged <18 years.ResultsSeventy‐three pediatric transplant centers from 32 countries contributed to the survey. All centers performed urological evaluation prior to pediatric kidney transplantation (KTx) with subsequent interdisciplinary discussion. Screening for VUR in native kidneys (30% in all, 70% in selected patients) led to surgical intervention in 78% (11% in all, 89% in selected patients) with a decided preference of endoscopic intervention over ureterocystoneostomy. Following KTx, continuous antibiotic prophylaxis was applied in 65% of the patients and screening for allograft VUR performed in 93% of selected patients. The main management strategies of symptomatic allograft VUR were continuous antibiotic prophylaxis (83%) and surgical treatment (74%) (endoscopic intervention 55%, redo ureterocystoneostomy 26%).ConclusionsThis survey demonstrates the high variability in the management of VUR in pediatric KTx recipients, points to knowledge gaps, and might serve as a starting point for improving the care for patients with VUR in native and transplanted kidneys.
Building consensus in defining and conceptualizing acceptability of healthcare: A Delphi study
Authors: Bucyibaruta Joy Blaise , Doriccah Mmapheko , Bamford Lesley , Elizabeth van der Wath Annatjie , Dyer Thomas Anthony , Murphy Andrea , Gatabazi Paul , Ajoke Anokwuru Rafiat , Muhire Innocent , Anna Coetzee Clarissa , Coetzee Helene , Musekiwa Alfred 
Published: December 2022

AbstractBackgroundThe concept of healthcare acceptability is important for nursing staff spending most of their time with patients. Nevertheless, acceptability remains confusing without a collective definition in existing literature.ObjectiveThis study aimed to create a consensus among experts on definition and conceptual framework of healthcare acceptability.MethodsWe conducted two rounds of Delphi surveys to collect opinions from experts on definition and conceptual framework of healthcare acceptability proposed following thematic content analysis. We calculated the consensus among experts using the modified Appraisal of Guidelines for Research & Evaluation II (AGREE II) instrument and followed the guidance on conducting and reporting Delphi studies (CREDES) best practices.ResultsA total of 34 experts completed two rounds of Delphi survey. The definition was validated through consensus as: “a multi‐construct concept describing the nonlinear cumulative combination in parts or in whole of experienced or anticipated specific healthcare from the relevant patients/participants, communities, providers/researchers or healthcare systems' managers and policy makers' perspectives in a given context.” The overall quality rating was 92.6% and 95.1% for the proposed definition and conceptual framework respectively.ConclusionOpinions collected from experts provided significant insights to build a consensus on healthcare acceptability advancing public health nursing.
Dose–Response Relationship of Photobiomodulation Therapy on Matrix Metalloproteinase in Healing Dynamics of Diabetic Neuropathic Ulcers—An in vivo Study
Authors: Karkada Gagana , Maiya G Arun , Arany Praveen , Rao KG Mohandas , Adiga Shalini , Kamath Shobha U. 
Published: December 2022

AbstractIndividuals with diabetic foot ulcers have overlapped the inflammatory, proliferative and remodeling phase, making the tissue vulnerable to delayed healing responses. We aimed to establish the dose–response relationship of photobiomodulation therapy of different doses and matrix metalloproteinases in the healing dynamics of diabetic neuropathic ulcers. Diabetes was induced in 126 Albino Wistar rats, and neuropathy was induced to the hind paw by a sciatic nerve injury method. An excisional wound was created on the neuropathy‐induced leg. Photobiomodulation therapy of dosages 4, 6, 8, 10, 12 and 15 J cm−2 and wavelength 655 nm and 808 nm was irradiated. Photobiomodulation therapy of dosages 4, 6 and 8 J cm−2 showed better wound healing properties with optimized levels of matrix metalloproteinases‐1 and 8. We observed a strong dose response in the experimental group treated with 6 and 8 J cm−2. The findings from the present study conclude that photobiomodulation therapy of dosages 4, 6 and 8 J cm−2 is suggestive of usefulness in diabetic neuropathic ulcer healing. Markers like matrix metalloproteinases may give a clear direction on response to the therapy. Based on the findings from the present study, we recommend to validate the findings for safety and efficacy in future through human prospective randomized controlled clinical trials.
Estimating Demographic Bias on Tests of Children's Early Vocabulary
Authors: Kachergis George , Francis Nathan , Frank Michael C. 
Published: December 2022

AbstractChildren's early language skill has been linked to later educational outcomes, making it important to measure early language accurately. Parent‐reported instruments, such as the Communicative Development Inventories (CDIs), have been shown to provide reliable and valid measures of children's aggregate early language skill. However, CDIs contain hundreds of vocabulary items, some of which may not be heard (and thus learned) equally often by children of varying backgrounds. This study used a database of American English CDIs to identify words demonstrating strong bias for particular demographic groups of children, on dimensions of sex (male vs. female), race (white vs. non‐white), and maternal education (high vs. low). For each dimension, many items showed bias; removing these items slightly reduced the magnitude of race‐ and education‐based group differences, but did not eliminate them. Additionally, we investigated how well the relative frequency of words spoken to young girls versus boys predicted sex‐based word learning bias, and discuss possible sources of demographic differences in early word learning.
The irrigation suitability potential of an effluent treated by a pseudo‐natural wetland
Authors: Mkilima Timoth 
Published: December 2022

AbstractThe performance of a pseudo‐natural wetland to purify wastewater for irrigation potential was explored in this study. To study the system's performance and the hazard level of the raw wastewater and treated effluent, several water quality parameters were chosen, including electrical conductivity (EC), total dissolved solids (TDS), sodium (Na+), calcium (Ca2+) and magnesium (Mg2+). Four different sampling points (inlet, two intermediate points, and the outlet) were investigated in the study. According to the electrical conductivity, wastewater flowing to the wetland was classified as category four (C4), ‘extremely high salinity’ and thus unfit for irrigation. Both intermediate sampling points were in C3, whereas the outlet sampling point was in C1. According to SAR, 20% of the samples collected at the inlet were classified as ‘very high sodium hazard’ (S4), 45% as ‘high sodium hazard’ (S3) and 35% as ‘medium sodium hazard’ (S2). The findings of this study also demonstrated that the pseudo‐natural wetland can be significantly effective in reducing pollution and providing suitable water for irrigation. Furthermore, the findings raise greater awareness of the importance of protecting and conserving these valuable resources, particularly in urban areas.
Analysis and Optimization of Crucial Factors Affecting Efficacy of Microwave Ablation
Authors: Avishek Shubhamshree , Samantaray Sikata 
Published: December 2022

Abstract
Microwave ablation (MA) has emerged as a better and more promising alternative to medicate the primitive stage of cancer. Significant advantages of MA include organ-specific treatment and the prospect of treating ≥3 cm diameter tumors with minimal pain and nominal cost. Past studies suggest that tissue properties and input parameters play a vital role during the MA process. Hence, an in-depth investigation has been made to inspect the influence of these crucial parameters: applied power, perfusion rate of blood, frequency, thermal conductivity (TC), electrical conductivity (EC), and relative permittivity (RP) on the dimension of ablation zone attained while treating with MA on Lungs. The finite element method (FEM)-based analysis with a numerical approach is considered to signify the parameters' sole effect on the ablation volume. Using the statistical tool, a regression equation was formulated, and the data derived from the Taguchi L27 orthogonal array helped to get the maximized ablation zone. The results infer that the applied power remarkably affects the response with a positive correlation. Additionally, frequency and blood perfusion rate were observed to significantly influence the treatment process. The following optimal settings, power3, frequency3, blood perfusion rate3, electrical conductivity3, thermal conductivity2, and relative permittivity2, were found along with the maximized ablation volume of 14.35 mm3. The results obtained from this work would be beneficial for the radiologist and the clinical practitioners to get pretreatment data during the initial phase.
Electro-Chemical Migration in Aerosol-Jet Printed Electronics Using Temperature-Humidity and Water Droplet Testing Methods
Authors: Zhao Beihan , Bharamgonda Aniket Ajitkumar , Jennings Eric , Utter Robert G. , Osterman Michael , Azarian Michael H. , Das Siddhartha , Dasgupta Abhijit , Fleischer Jason , Quinn Edwin , Hines Daniel 
Published: December 2022

Abstract
In this study, temperature-humidity-bias (THB) testing and water droplet (WD) testing have been conducted to study electro-chemical migration (ECM) and dendrite formation across features in aerosol jet printed (AJP) conductor patterns. Test specimen design and testing conditions were guided by industrial standards and related research studies. Time-to-failure (TTF) for AJP printed silver patterns is found to be much smaller than that for conventional copper patterns in THB testing, under identical testing conditions. Furthermore, TTF for dendrite growth between neighboring biased conductors at constant temperature and humidity conditions was found to have a non-monotonic dependence on the electric potential gradient. The dendrite density was found to vary significantly with different applied voltage gradients in both THB testing and WD testing. Those observations can help to guide future investigation and life-prediction modeling of AJP printed electronics subjected to combined temperature, humidity, and voltage stresses.
Power Envelope Analysis for the Thermal Optimization of a Chiplet Module
Authors: Ouyang Eric , Gu Xiao , Jeong Yonghyuk , Liu Michael 
Published: December 2022

Abstract
In this paper, the thermal performances of a Chiplet module with different numbers of dies were studied. The Chiplet module was assumed to be placed in the same server system, with the same ambient condition, and using the same heat sink. A thermal simulation was conducted to obtain the junction temperatures of dies using different power magnitudes. With the change of power magnitudes of the dies, a thermal resistor matrix was calculated. Finally, with the calculation of the thermal resistor matrix, a unique power envelope plot was developed to determine if the power magnitudes of the chips on the Chiplet module caused any reliability concern. A risk factor was calculated to determine if the power magnitude of the die is within the safe region. With risk factors, we will be able to quantify the differences of applied powers with respect to the maximum allowed limits. We have expanded the usage of the power envelope plots to the Chiplet modules having more than three dies. The power envelope plots are a good tool for designers to optimize the power magnitudes, especially at the early stage of the Chiplet module design.
Numerical Modeling and Experimental Validation on Non-Contact Bernoulli Picker for 3D Device Stacking Process
Authors: Min Daeho , Han Minsoo , Kim Juno , Lee Kangsan , Lim Kyeongbin , Choi Euisun , Seok Seung Dae , Lee Byeongjun , Rhee Minwoo Daniel 
Published: December 2022

Abstract
This paper focuses on numerical computation and experimental examination of Bernoulli picker, which is the essential module for the 3D stacking process for heterogeneous integration devices, to reveal the fundamental physics of non-contact die handling and to seek optimized design. We estimated the pick-up performance of the Bernoulli picker and the deformation of the die using pseudo-coupling of flow and structural analysis. We simulated the flow field around the target die and picker using the RANS equation with the k-w SST turbulence model to predict the levitation height between the picker surface and target die. Then we estimated the deformation of the die using the inertial relief approach of ABAQUS with computed pressure field information. Based on the numerical investigations, we made a prototype of a Bernoulli picker and conducted experimental measures to verify the feasibility of our design. The measured results indicate that the present numerical approach can be utilized for further optimization.
Evaluation of Electromigration Coupling Different Physics Fields in Numerical Simulation
Authors: Cai Chongyang , Xu Jiefeng , Lai Yangyang , Yang Junbo , Wang Huayan , Ramalingam Suresh , Refai-Ahmed Gamal , Park Seungbae 
Published: December 2022

Abstract
With the minimization trend of component size, electromigration is becoming an increasingly important concern. Current studies mainly focused on predicting the EM time to failure (TTF) based on Black’s equation. By simulating the current and temperature, TTF of test structures can be calculated. However, the current distribution is not considered in Black’s equation and this method may not be able to describe the current redistribution and current crowding effects. Some numerical models have been developed to simulate the current redistribution and joule heating influence. Still, electromigration is a Multiphysics phenomenon that couples not only electric and thermal fields but also includes atomic diffusion and stress migration. To simulate the actual migration behavior, the influence of different physic fields needs to be considered. In this paper, we employed different physics fields on test vehicle simulations: electrical-diffusion, electrical-thermal-diffusion and structural-thermal-electric-diffusion. The results of EM behavior as well as the computational time are compared.
Determination of the Thermal Performance Limits for Single Phase Liquid Cooling Using an Improved Effectiveness-NTU Cold Plate Model
Authors: Ortega Alfonso , Caceres Carol , Uras Umut , Kisitu Deogratius , Chowdhury Uschas , Radmard Vahideh , Heydari Ali 
Published: December 2022

Abstract
Cold plates are at the heart of pumped liquid cooling systems. In this paper, we report on combined experimental, analytical, and computational efforts to characterize and model the thermal performance of advanced cold plates in order to establish their performance limits. A novel effectiveness-NTU formulation is introduced that models the fin array as a secondary “pseudo-fluid” such that accurate crossflow effectiveness models can be utilized to model the cold plates using well-known formulations. Experimental measurements and conjugate CFD simulations were made on cold plates with fin and channel features of order 100 um with water-propylene glycol (PG) mixtures as coolants. We show that for a fixed fin geometry, the best thermal performance, regardless of the pressure drop, is achieved when the flow rate is high enough to approach the low NTU convective limit which occurs for NTU approaching zero. For the model cold plate evaluated in this study, the lowest thermal resistance achieved at a flow rate of 4 LPM was 0.01 C/W, and the convective limit was 0.005 C/W. However, for a fixed pressure drop, the optimal cold plate should be designed to meet its TDP at the highest possible effectiveness in which the lower limit of thermal resistance is the advective limit achieved for NTU &gt; 7. For the tested cold plate the advective limit for the thermal resistance is 0.003 C/W, but this limit can only be achieved if it is practically feasible to increase the surface area and heat transfer coefficient to maximize NTU for a targeted TDP.
Predictive Methods for Electrical and Mechanical Process-Output for Inkjet Additive Printed Circuits
Authors: Lall Pradeep , Goyal Kartik , Miller Scott 
Published: December 2022

Abstract
In this paper, predictive models are developed for inkjet printed features regarding their electrical and mechanical performance and to help reduce the initial process time in selecting print parameters. Printed electronics are continuously getting immense interest with a steady increase in its areas of end applications. The process generally involves controlled deposition of material on a substrate to additively build the required structure. Due to the nature of additive printing, benefits such as reduced time to manufacturing and the possibility of flexible and conformable electronics can be easily achievable. Under the umbrella term of additive printing, Inkjet printing is one technique that is sometimes known as the workforce of mass manufacturing due to the number of nozzles ranging in hundreds or even thousands, with which it can print the structures. The process, also known as drop-on-demand, involves the deposition of liquid ink droplets as per the required structure. However, for deposition, inkjet requires control of certain process parameters that impact the print resolution and, thus, the printed material properties. Thus, it is important to have a predictive framework that helps select those significant parameters. Silver Nanoparticle-based ink is utilized that is compatible with the viscosity range allowed in the printer. For the predictive framework development, a statistical approach is implemented that consists of a design-of-experiments (DOE) matrix with significant parameters that have a major impact on the resolution and properties of the material. The study’s response variables consist of the printed feature’s electrical and mechanical properties. The aim of this study is to provide statistical models that can be used with Inkjet process parameters as an input to predict the properties of the final printed feature.