bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brainstem modulation of nociception by periaqueductal gray neurons expressing the mu-opioid receptor
Authors: Nguyen Eileen , Chiang Michael C. , Nguyen Catherine , Ross Sarah E. 
Published: August 2022

AbstractPharmacological manipulations directed at the periaqueductal gray (PAG) have revealed the importance of the mu-opioid receptor in the endogenous pain-modulatory system. Despite the clear role for opioidergic signaling within the PAG for the descending modulation of pain, the molecular and anatomical characterizations of neurons containing the mu-opioid receptor remain elusive. Using combinatorial anatomical, optogenetic, and chemogenetic approaches, we delineate a supraspinal pathway centered on PAGMOR neurons in the modulation of pain and itch behaviors. We found that chemogenetic manipulations of PAGMOR neurons in assays of nociception unveiled complex results; whereas activation of these neurons generally facilitated responses to noxious stimuli and jumping behaviors on the hotplate assay, opposing patterns were observed with reflexive responses to sensory testing. Activation of PAGMOR neurons also robustly inhibited itch. These dichotomous findings across distinct types of sensory testing emphasize the contextual behavioral expression of nociception using reflexive and noxious paradigms. Lastly, we uncovered the role for PBN projections in the PAG that modulate pain in an uninjured, post-surgical state of latent sensitization.
Prenatal diagnosis and genetic counseling of an inherited unbalanced chromosome abnormalities in a Chinese family
Authors: Zhang Ying , Chen Juan , Feng Zonghui , Li Wencheng 
Published: August 2022

Abstract
Background
Unbalanced chromosome abnormalities (UBCA) are either gains or losses or large genomic regions, but the affected person is not or only minimally clinically affected. Copy number variants (CNVs) are an important source of normal and pathogenic genome variations. CNVs and UBCA identified in prenatal cases need careful considerations and correct interpretation if those are harmless or harmful variants from the norm.

Case presentation
A 25-year-old, gravida 1, para 0, woman underwent amniocentesis at 18 weeks of gestation because the noninvasive prenatal testing (NIPT) results revealed a 6.8 Mb duplication from 2q11.1 to 2q11.2. Chromosomal microarray analysis (CMA) was performed on uncultured amniocytes. GTG-banding karyotype analysis on cultured amniocytes was performed.

Results
Chromosomal GTG-banding of the cultured amniocytes revealed a karyotype of 46,XX. CMA detected a 6.8-Mb chromosomal duplication in the region of 2q11.1q11.2 (arr[GRCh37] 2q11.1q11.2(95,327,873_102,088,148)x3).

Conclusion
Chromosomal microdeletions and microduplications are difficult to detect by conventional cytogenetics, combination of prenatal ultrasound, karyotype analysis, NIPT, CMA and genetic counseling is helpful for the prenatal diagnosis of UBCA and chromosomal microdeletions/microduplications.
Hysteroscopic versus laparoscopic management in patients with communicating hydrosalpinx and planning for IVF: a randomized controlled trial
Authors: Rashwan Ahmed S. S. A. , Alalfy Mahmoud , Riad Reda I. , Elsherbini Moutaz , Abdelsalam M. A. , Abdel-Rasheed Mazen , Lasheen Yossra 
Published: August 2022

Abstract
Background
Hydrosalpinx is considered one of the obstacles that could hinder the success of IVF techniques due to the toxic effect of the hydrosalpinx fluid pouring into the uterine cavity. Tubal disconnection by either hysteroscopic or laparoscopic approaches is considered the standard in the operative management of hydrosalpinx prior to IVF cycles. The aim of the current study was to compare the success rate of hysteroscopic tubal occlusion using electro-coagulation with laparoscopic tubal disconnection in cases of hydrosalpinx prior to in vitro fertilization (IVF).

Methods
A total of 108 women with unilateral or bilateral hydrosalpinx, who were candidates for tubal occlusion before IVF, were equally randomized into two groups. Group A (n = 54) underwent hysteroscopic tubal occlusion using the roller-ball electro-coagulation of the interstitial part of the tube and the uterine cornual area, and group B (n = 54) underwent laparoscopic tubal disconnection using bipolar coagulation and a proximal tubal cut. Operative time, complications, postoperative pain measured by the visual analogue score (VAS score), and postoperative hospital stay were recorded for both groups. The success rate of tubal occlusion was assessed 1 month later using a post-menstrual hysterosalpingogram (HSG).

Results
Laparoscopic tubal disconnection was more successful than the hysteroscopic approach regarding tubal occlusion rate (96.15% vs. 86.67% respectively, p = 0.044). The operative time and postoperative pain VAS scores in the hysteroscopy group (3.65 ± 1.03 min and 1.81 ± 1.35, respectively) were significantly lower than that in the laparoscopy group (17.48 ± 4.70 min and 4.06 ± 1.65, respectively) with p < 0.001.

Conclusion
Although laparoscopic tubal disconnection is more successful, the hysteroscopic approach is an alternative which has its own limitations that can be assessed by hysterosalpingogram, especially when laparoscopy is contraindicated, technically difficult, or refused by the patient.

Trial registration
It was first registered at ClinicalTrials.gov on 30/07/2019 with registration number NCT04037813.
A Novel Defined Pyroptosis-Related Gene Signature for Predicting Prognosis of Acute Myeloid Leukemia
Authors: Wang Fan 
Published: August 2022

Abstract
Background: Pyroptosis is an inflammatory form of programmed necrotic cell death, but its potential prognostic value in acute myeloid leukemia (AML) remains unclear. In this study, we aimed to construct a pyroptosis genes related signature that can effectively predict the prognosis of AML patients.Methods: Based on the available AML data from TCGA and TARGET databases, a pyroptosis-related prognostic model was constructed by performing a LASSO Cox regression analysis, and the predictive value of the model was validated in a GEO cohort. The impact of pyroptosis on the immune microenvironment of AML was explored as well. The chemotherapeutic drug Sensitivity was further evaluated.Results: A 10-gene signature model was constructed to effectively predict AML prognosis, which showed that patients with low-risk score had a significantly better prognosis than the high-risk group, and receiver operator characteristic (ROC) analysis proved superior performance of the prognostic model. The model was further verified well in an external GEO cohort. Multivariable Cox regression analysis showed that in addition to age, the risk score was also an independent poor survival factor for AML patients, and a nomogram model were constructed with high accuracy. Moreover, the high-risk group generally had higher activity of cytolytic activity and increased levels of infiltrating immune cells including tumor-infiltrating lymphocytes (TILs) and regulatory T cells (Tregs), which could be related with the expression of ICPs. Additionally, low-risk AML patients may get better response from the traditional chemotherapeutic drugs (cytarabine, doxorubicin, docetaxel and etoposide).Conclusion: A pyroptosis-related gene signature can independently predict the prognosis of AML patients with sufficient predictive power, and pyroptosis plays an important role in the immune microenvironment of AML, which may be used to develop a new effective therapeutic method for AML in the future.
Insect Diversity in Taman Jangkar Surabaya
Authors: Aini Nurul , Khitiyah Ana Mariatul 
Published: August 2022

Insects are animals with jointed legs that are often found in many places with various types. This is because insects have a very high level of adaptation, for example those found in the Taman Jangkar in Surabaya. The purpose of this study was to describe the diversity of insects in the Taman Jangkararea and to compare the number of members of each insect order in the Taman Jangkar area. The method used in this research task is observation, which is to go directly to the field to capture insects around Taman Jangkar Surabaya with 4 repetitions in each plot, then collect data for identification. Based on the results of observations, collection, and identification, it can be obtained that there are various insects in the area. This is evidenced by the discovery of various orders of insecta, including: order Lepidoptera, order Odonata, order Hymenoptera, order Diptera, and order Orthoptera. Comparison of the number of species from each order is different. The most dominant number of species is in the order Lepidoptera which is then followed by the order Hymenoptera
Análise do eletrocardiograma diante de alteração do posicionamento dos eletrodos: ensaio clínico controlado
Authors: Calazans Jessica de Oliveira , Carvalho Lorena Xavier Rocha , Pereira Monaliza Gomes , Silva Renata Flavia Abreu da 
Published: August 2022

Objetivo: Analisar o registro eletrocardiográfico diante da intervenção no posicionamento dos eletrodos no tórax comparada ao método standard. Método: Ensaio clínico controlado, simples cego, realizado com 41 pacientes, que compuseram o grupo controle e intervenção, gerando registros que foram laudados por dois profissionais de saúde, proficientes em cardiologia. Resultados: Foram analisados 82 eletrocardiogramas, tendo como direcionamento os protocolos controle e intervenção, nos quais constavam a descrição das técnicas correta e incorreta, respectivamente. A maioria das variáveis estudadas não apresentou diferença estatística significativa quanto aos laudos analisados diante da comparação entre os protocolos aplicados. A exceção foi referente à onda P, apresentando-se negativa em V1 quando deveria estar positiva, evidenciada na comparação entre 14 pares de eletrocardiogramas (P = 0,003). Conclusão: O posicionamento incorreto dos eletrodos afetou o registro da derivação V1. Considerando-se o eletrocardiograma de doze derivações usualmente realizado na prática clínica, salienta-se quanto ao possível confundimento devido aos marcos anatômicos base de outros procedimentos, como, por exemplo, os focos de ausculta cardíaca. Sugere-se o desenvolvimento de critérios adicionais e tecnológicos para o reconhecimento e detecção de erros de localização do eletrodo, bem como a capacitação profissional ser condição sine qua non para a realização do exame de eletrocardiografia. (ReBEC - NCT: RBR-9h4tp3).
Retroperitoneal Abcess Profiles in a Tertiary Hospital in Bandung, Indonesia : Long Term Retrospective Study
Authors: Saputra Daniel , Ardiansjah Ricky 
Published: August 2022

Retroperitoneal abscess is a rare and difficult-to-diagnose condition. The delay in diagnosis is the primary cause of mortality. We did a case series investigation to describe the profiles of retroperitoneal abscesses. We obtained retrospective data from medical records. We reviewed thirty patients admitted to our hospital with retroperitoneal abscesses from January 2013 to December 2019. Of 30 patients reviewed, 56.67% were male, with 50.14 years-old mean age. Approximately 46.67% presented with a chief complaint of back pain, and about 63.33% of cases had a fever. The most prevalent source was genitourinary, which accounted for 60% of the cases. The most common type of abscess was the perirenal abscess. Diabetes mellitus, malignancy, and an immunocompromised condition were all prevalent comorbidities. Escherichia coli was the most prevalent pathogen (46.66%), followed by Klebsiella pneumoniae (26.67%). For genitourinary abscesses, percutaneous drainage was typically used, whereas surgical drainage was recommended for gastrointestinal abscesses. The mortality rate of those conditions was 13.33%. Retroperitoneal abscesses have a wide range of clinical manifestations and causes. The treatment for retroperitoneal abscesses differed depending on the etiology and severity of the infection.
Altruistic Behavior and Subjective Happiness of University Students Specialized in Special Education
Authors: Mohamed Atef Azazzy Ahmed 
Published: August 2022

The present study aims at investigating the relationship between altruistic behavior and Subjective happiness among a sample of university students specializing in special education, and to find differences between them according to gender, Country.
The sample of study consists of (523) male and female students from the Saudi and Egyptian universities. The researcher uses scale Altruistic behavior (prepared by the researcher) and the Oxford list of happiness Translated by Abdel-Khaleq et al. 2003), as a descriptive analytical approach is used. The findings of the study show of finding a statistically significant correlation between altruistic behavior and Subjective happiness of university students specializing in special education. The results show that there are statistically significant differences in Altruistic behavior component (love and sympathy for others) in favor of females, Altruistic behavior components (assistance others, altruistic participation) in favor of male, while there are no statistically significant differences in components (Prioritization others, altruistic participation) and Altruistic behavior as a whole. The results show that there are statistically significant differences in Altruistic behavior components (Assistance others, Altruistic participation) in favor of Saudi students, while there are no statistically significant differences in components (Love and sympathy for others, Prioritization others) and Altruistic behavior as a whole. The results show that there are statistically significant differences in Subjective happiness attributed to gender in favor of male, and there are significant statistical differences attributed to Country in favor of Saudi students. As we can predict Subjective happiness through Altruistic behavior.
The Duality of al-Zahir and al-Batin (the esoteric interpretation): A Reading of the Diwani Messages in Egypt during the Fatimid era
Authors: Alnaimat Mohammad , Almhameed Atef 
Published: August 2022

This paper deals with the study of the impact of the Shiism on the Arabic literature in general, and on the Fatimid literature in particular. It treats the issue of)al-Zahir and al-Batin(in the Holy Qur’an or what is called the esoteric interpretation. The Fatimid writers exerted more attention and paid their effort in employing Qur’anic verses through esoteric interpretation, their goal in that was to get the Imamate or the Caliphate, it was the utmost motivation for the esoteric interpretation. the Imamate was right for Ali bin Abi Talib and for his descendants and they sought to maintain this right contextually not by selection. The study deals with the concept of "esoteric interpretation" and its relationship to the issue of Alzaher and Albatin (deep and surface meaning), as it was mentioned in the Diwaniyah letters of the Fatimid writers. It also examines the manifestations of the esoteric interpretation with the Imam on one side and with the Fatimid writers on the other side. The study ends with presenting the elements of their use of esoteric interpretation through selected models from the Diwaniya messages, directly related to the thought and belief of the Fatimids.
The Role of Citizen’s Journalism in Achieving Sustainable Development in Light of Vision of 2030
Authors: Boubaker Ghazouani Samia 
Published: August 2022

This research aims to investigate the role of citizen’s journalism in the Kingdom of Saudi Arabia in achieving the sustainable development that the Vision of 2030 programs and plans brought in. We used the descriptive approach and the questionnaire tool that we distributed to a random sample of 350 individuals to answer research questions and achieve its goals. The results showed that the use of social media is the main form of citizen journalism practice and that these communication and media practices for the general public can contribute to achieving the sustainable development called for by Vision of 2030 in terms of simplifying information, explaining, interpreting and promoting development vision goals, plans and programs in addition to strengthening the love of the nation and spreading awareness in society and alerting to excesses and assisting official bodies and agencies in the performance of their tasks as well Citizen journalism can give the opportunity to participate in national development programs and plans and achieve sustainable development in the Kingdom.
The Media Briefings of the MOHAP and its Communication Content to Raise Awareness of the Coronavirus
Authors: Aissani Rahima 
Published: August 2022

At the outbreak of disease and epidemics, governments and health-care organizations prepare emergency crisis management plans, developed based on information and guidance from the World Health Organization. These include preparedness, response and recovery strategies, media and public communication are an important component of their implementation. The concept of crisis communication implies that honest, candid, quick, accurate and full response to the crisis is one of the basic requirements of crisis management. The study aims to reveal the type of communication content presented by the media briefings of the MOHAP awareness of the Coronavirus and to curb its spread. The study adopted a curriculum for content analysis(quantitative and qualitative)of the periodic briefings organized by the Ministry over four months (March, April, May, June), starting from the first briefing held on Saturday, March 7, 2020 ended with the last regular briefing on Tuesday, June 27, 2020. The study found several results, the most important of which were: The MOHAP has been quick, organized and effective in its communication response; Periodic briefings were organized on the latest developments and figures regarding Coronavirus cases in the State, government actions and initiatives announced to curb the spread of COVID19. The study recommends that further studies be undertaken to implement the CERC Crisis and Risk Management Communications Model, in order to reveal the effectiveness of crisis communication applied by the bodies and organizations in the Arab region to manage crises and risks, both in communications and in the media
المحاسن البلاغية في الصحيح لمسلم من بَابُ الْوَصِيَّةِ بِالثُّلُثِ:دراسة تحليلية
Authors: Khan Sharif , Syed ul Hassanat Dr. Muhammad 
Published: August 2022

There is no doubt that Aḥādīths (sayings) of The Prophet (PBUH) have the great importance in the Islamic Jurisprudence because it is the second source of Islamic law after the Holy Quran. Due to the immense importance of Aḥādīth, the religious and research Scholars have paid a close attention to emerge and highlight the all aspects of Aḥādīth regarding Islamic Jurisprudence, Arabic Literatures and Rhetorical peculiarities etc. Imam Muslim's book Ṣaḥīḥ Muslim contains texts which are examples of Rhetorical. Every chapter in Imam Muslim's book is an example of rhetoric. But the main question of this research is what is the rhetoric in Kitāb al ul Waṣiyyah Bil Thuluth? The answer to this question is required in this research. Therefore the scholars have tried their best in this article to discuss the Rhetorical peculiarities of the Ṣaḥīḥ Muslim from Kitāb al ul Waṣiyyah Bil Thuluth as well as, I have analyses the definition of Rhetoric in line with different ancient modern scholars.
Evaluation of the biological activity of the aqueous extract of Teucrium Polium on some biochemical parameters in Oryctolagus cuniculus male rabbits
Authors: Kareem Israa Khalaf Abdul , Hamza Naseer Marza 
Published: August 2022

The current study aims to know the protective effects of the aqueous extract of the plant Teucrium Polium to reduce the toxic effects of the liver caused by sodium benzoate in male rabbits of the type Oryctolagus cuniculus by studying some biochemical parameters ,whereas the results of the current study showed that animals dosing with sodium benzoate at a concentration of (250)mg/kg of body weight for 30 days led to a significant increase at(p <0.05)in the concentration of liver enzymes (AST, ALT, ALP)and a significant decrease in the concentration of oxidative enzymes (GSH, CAT) at (p <0.05) in the blood serum of the animals of the positive control group when compared with the animals of the negative control group.
Effect of volatile oils extracted from orange peels Citrus sinensis and silver nanoparticles manufactured from it on the concentration of glutathione (GPX) and Levels of oxidative stress Malondialdehyde (MDA) and ‏Lipid ‎peroxides (LPO) in the serum of ma
Authors: Al-Sharifi Hussein Fouad Hamza , Alnomani Ruqayah Manoon Hasan 
Published: August 2022

Citrus Citrus fruits are used for the prevention of many chronic diseases such as cancer, diabetes, and cardiovascular diseases. The leaves and fruits of the citrus genus contain antioxidants. The oil of the family plants has uses in folk medicine, The results also showed a significant increase in the concentration of glutathione ‎peroxidase (GPX) when treated with orange peel extract at a concentration of 450 ‎mg/kg and 1 ml/kg of hydrogen peroxide, which amounted to 64.77‎±1.3 ‎ μmol/L ‎Compared to With the treatment that was dosed only with 1 ml/kg of hydrogen ‎peroxide H2O2 as its concentration level was 43.69 ±4.1 μmol/L, there were also ‎significant differences for the treatment when dosed with 0.6 mg/kg with ‎nanosilver and 1 mm/kg of peroxide. The hydrogen peroxide amounted to 57.32 ‎‎±6.2 μmol/L, while the concentration of malondialdehyde (MAD) decreased ‎significantly when treated with orange peel extract at a concentration of 450 mg/kg ‎and 1 ml/kg of hydrogen peroxide, reaching 0.390±0.056 μmol/L (representing the ‎lowest concentration of MAD levels) compared to the treatment dosed with only 1 ‎ml/kg of hydrogen peroxide of 0.757‎‏±‏‎ 0.021‎‏ ‏μmol/L,,,
Risco de internação hospitalar, fragilidade, mobilidade corporal e prevalência de internações por condições sensíveis à atenção primária de idosos rurais no Rio Grande do Sul
Authors: Trindade Jorge Luiz De Andrade , Dias Alexandre Simões 
Published: August 2022

O objetivo desta pesquisa foi estabelecer relações entre o risco de hospitalização, fragilidade e mobilidade de idosos trabalhadores rurais com a prevalência de Internações por Condições Sensíveis à Atenção Primária (ICSAP) no estado do Rio Grande do Sul, utilizando um modelo multivariado de equações estruturais. Estudo realizado com dois delineamentos em três etapas. Na primeira etapa, estudo transversal com 604 idosos, aposentados identificados em sindicatos de trabalhadores rurais. A sistematização de coleta considerou metodologia por conglomerados (regionais sindicais, sindicatos e comunidades de base sindical e população rural aposentada). A segunda etapa compreendeu um estudo ecológico, das morbidades indicadas pela portaria nº 221 de 2008 (SAS/MS 221), com dados do Sistema de Informação Hospitalar (SIH/SUS). Na terceira etapa foi utilizado modelagem de equações estruturais (MEE) para estudar as variáveis pesquisadas na predição de internação hospitalar de idosos rurais do estado. O modelo identificado pressupõe relações entre fragilidade, Probabilidade de Internações Repetidas (PIR) e mobilidade com as ICSAP. Ainda que a maioria dos elementos utilizados se mostrem convergentes aos riscos de hospitalização, há necessidade de novos estudos para o aprimoramento do modelo, tornando-o mais adequado para um padrão que sirva de referência para investigações sobre o tema.