bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-reported periodontitis and C-reactive protein in Parkinson’s disease: a cross-sectional study of two American cohorts
Authors: Lyra Patrícia , Botelho João , Machado Vanessa , Rota Silvia , Walker Ryan , Staunton Juliet , Proença Luís , Chaudhuri Kallol Ray , Mendes José João 
Published: April 2022

AbstractPeriodontitis triggers systemic repercussions, such as elevated levels of high-sensitive C-reactive protein (hs-CRP). This has never been studied within Parkinson’s Disease (PD). The aim of this study is to compare hs-CRP levels of self-reported periodontitis cases versus cases without periodontitis in PD patients. Data from the National Health and Nutrition Examination Survey (2015–2016 and 2017–2018 waves) were analyzed. PD cases were identified through medication regimens and periodontitis cases through a validated self-report questionnaire. 51 participants were included (24 females, 27 males, with mean age of 62.96 (14.71)). While the self-reported periodontitis group presented elevated levels of circulating hs-CRP (5.36 vs. 1.99 mg/L,p = 0.031), the self-reported without periodontitis group presented higher lymphocyte levels (29.35 vs. 28.03%,p = 0.007). Blood levels of hs-CRP were significantly higher in PD cases with self-reported periodontitis. Apart from the lymphocyte levels, there were no other significant differences according to the self-reported periodontal status. Future studies shall explore this association using clinical measures.
Thermophotovoltaic efficiency of 40%
Authors: LaPotin Alina , Schulte Kevin L. , Steiner Myles A. , Buznitsky Kyle , Kelsall Colin C. , Friedman Daniel J. , Tervo Eric J. , France Ryan M. , Young Michelle R. , Rohskopf Andrew , Verma Shomik , Wang Evelyn N. , Henry Asegun 
Published: April 2022

AbstractThermophotovoltaics (TPVs) convert predominantly infrared wavelength light to electricity via the photovoltaic effect, and can enable approaches to energy storage1,2and conversion3–9that use higher temperature heat sources than the turbines that are ubiquitous in electricity production today. Since the first demonstration of 29% efficient TPVs (Fig. 1a) using an integrated back surface reflector and a tungsten emitter at 2,000 °C (ref.10), TPV fabrication and performance have improved11,12. However, despite predictions that TPV efficiencies can exceed 50% (refs.11,13,14), the demonstrated efficiencies are still only as high as 32%, albeit at much lower temperatures below 1,300 °C (refs.13–15). Here we report the fabrication and measurement of TPV cells with efficiencies of more than 40% and experimentally demonstrate the efficiency of high-bandgap tandem TPV cells. The TPV cells are two-junction devices comprising III–V materials with bandgaps between 1.0 and 1.4 eV that are optimized for emitter temperatures of 1,900–2,400 °C. The cells exploit the concept of band-edge spectral filtering to obtain high efficiency, using highly reflective back surface reflectors to reject unusable sub-bandgap radiation back to the emitter. A 1.4/1.2 eV device reached a maximum efficiency of (41.1 ± 1)% operating at a power density of 2.39 W cm–2and an emitter temperature of 2,400 °C. A 1.2/1.0 eV device reached a maximum efficiency of (39.3 ± 1)% operating at a power density of 1.8 W cm–2and an emitter temperature of 2,127 °C. These cells can be integrated into a TPV system for thermal energy grid storage to enable dispatchable renewable energy. This creates a pathway for thermal energy grid storage to reach sufficiently high efficiency and sufficiently low cost to enable decarbonization of the electricity grid.
Climate effects on archaic human habitats and species successions
Authors: Timmermann Axel , Yun Kyung-Sook , Raia Pasquale , Ruan Jiaoyang , Mondanaro Alessandro , Zeller Elke , Zollikofer Christoph , Ponce de León Marcia , Lemmon Danielle , Willeit Matteo , Ganopolski Andrey 
Published: April 2022

AbstractIt has long been believed that climate shifts during the last 2 million years had a pivotal role in the evolution of our genus Homo1–3. However, given the limited number of representative palaeo-climate datasets from regions of anthropological interest, it has remained challenging to quantify this linkage. Here, we use an unprecedented transient Pleistocene coupled general circulation model simulation in combination with an extensive compilation of fossil and archaeological records to study the spatiotemporal habitat suitability for five hominin species over the past 2 million years. We show that astronomically forced changes in temperature, rainfall and terrestrial net primary production had a major impact on the observed distributions of these species. During the Early Pleistocene, hominins settled primarily in environments with weak orbital-scale climate variability. This behaviour changed substantially after the mid-Pleistocene transition, when archaic humans became global wanderers who adapted to a wide range of spatial climatic gradients. Analysis of the simulated hominin habitat overlap from approximately 300–400 thousand years ago further suggests that antiphased climate disruptions in southern Africa and Eurasia contributed to the evolutionary transformation of Homo heidelbergensis populations into Homo sapiens and Neanderthals, respectively. Our robust numerical simulations of climate-induced habitat changes provide a framework to test hypotheses on our human origin.
Wearing face masks and possibility for dry eye during the COVID-19 pandemic
Authors: Fan Qian , Liang Minhong , Kong Wenjun , Zhang Wei , Wang Hongxia , Chu Jie , Fang Xin , Song Yi , Gao Wenjing , Wang Yan 
Published: April 2022

AbstractThis population-based observational, cross-sectional, and descriptive survey was to investigate the relationship of increased face mask usage in the coronavirus disease (COVID-19) era with mask-associated dry eye (MADE). Participants aged 6–79 years old with formal school education were selected. All participants finished the 19-item questionnaire online, distributed through different social media platforms. From 6925 participants who submitted eligible questionnaires, MADE was reported in 547 participants, which included 419 participants who developed new dry eye symptoms after wearing face masks and 128 participants whose pre-existing dry eye symptoms worsened with mask wearing. Longer time of face mask wearing, nonstandard wearing of face masks, reduced outdoor time, decreased daily reading time, shortened visual display terminals time, and dry environment were positively associated with MADE. There were significant associations between perceived MADE and age, female sex, education, use of glasses and contact lenses, and pre-existing dry eye. MADE was more common in adults aged > 20 years than those aged ≤ 20 years or juveniles. MADE incidence increased. Standard wearing of face masks was suggested as a protective factor for MADE. Awareness about the possible risk of MADE should also be created and the clinical dry eye signs should be verified.Clinical trial registration number: NCT04744805.
State-of-the-art retinal vessel segmentation with minimalistic models
Authors: Galdran Adrian , Anjos André , Dolz José , Chakor Hadi , Lombaert Hervé , Ayed Ismail Ben 
Published: April 2022

AbstractThe segmentation of retinal vasculature from eye fundus images is a fundamental task in retinal image analysis. Over recent years, increasingly complex approaches based on sophisticated Convolutional Neural Network architectures have been pushing performance on well-established benchmark datasets. In this paper, we take a step back and analyze the real need of such complexity. We first compile and review the performance of 20 different techniques on some popular databases, and we demonstrate that a minimalistic version of a standard U-Net with several orders of magnitude less parameters, carefully trained and rigorously evaluated, closely approximates the performance of current best techniques. We then show that a cascaded extension (W-Net) reaches outstanding performance on several popular datasets, still using orders of magnitude less learnable weights than any previously published work. Furthermore, we provide the most comprehensive cross-dataset performance analysis to date, involving up to 10 different databases. Our analysis demonstrates that the retinal vessel segmentation is far from solved when considering test images that differ substantially from the training data, and that this task represents an ideal scenario for the exploration of domain adaptation techniques. In this context, we experiment with a simple self-labeling strategy that enables moderate enhancement of cross-dataset performance, indicating that there is still much room for improvement in this area. Finally, we test our approach on Artery/Vein and vessel segmentation from OCTA imaging problems, where we again achieve results well-aligned with the state-of-the-art, at a fraction of the model complexity available in recent literature. Code to reproduce the results in this paper is released.
Weighted p-norm distance t kernel SVM classification algorithm based on improved polarization
Authors: Liu Wenbo , Liang Shengnan , Qin Xiwen 
Published: April 2022

AbstractThe kernel function in SVM enables linear segmentation in a feature space for a large number of linear inseparable data. The kernel function that is selected directly affects the classification performance of SVM. To improve the applicability and classification prediction effect of SVM in different areas, in this paper, we propose a weightedp-norm distance t kernel SVM classification algorithm based on improved polarization. A t-class kernel function is constructed according to the t distribution probability density function, and its theoretical proof is presented. To find a suitable mapping space, the t-class kernel function is extended to thep-norm distance kernel. The training samples are obtained by stratified sampling, and the affinity matrix is redefined. The improved local kernel polarization is established to obtain the optimal kernel weights and kernel parameters so that different kernel functions are weighted combinations. The cumulative optimal performance rate is constructed to evaluate the overall classification performance of different kernel SVM algorithms, and the significant effects of differentp-norms on the classification performance of SVM are verified by 10 times fivefold cross-validation statistical comparison tests. In most cases, the results using 6 real datasets show that compared with the traditional kernel function, the proposed weightedp-norm distance t kernel can improve the classification prediction performance of SVM.
Applications of zeolite-zirconia-copper nanocomposites as a new asphaltene inhibitor for improving permeability reduction during CO2 flooding
Authors: Mansouri Mohsen , Ahmadi Yaser 
Published: April 2022

AbstractUsing nanoparticles for adsorbing asphaltene was known as an efficient method among researchers for crude oil upgrading. In this study, zeolite-zirconia-copper nanocomposites (NCs) have been synthesized and characterized with Scanning electron microscopy (SEM), X-ray diffraction (XRD), Brunauer–Emmett–Teller (BET), and energy-dispersive X-ray (EDX). Then, CO2-oil interfacial tension (IFT) tests, Ultraviolet–visible spectroscopy (UV–Vis) Langmuir and Freundlich isotherm models, asphaltene precipitation tests at static phase, and dynamic CO2 flooding tests were performed in the presence of NCs and the results were compared with zeolite nanoparticles. Based on the characterization results, zirconia-copper particles were distributed at the surface of zeolite with total dimensions less than 30 nm, and the specific surface areas of the NCs (327.82 m2/g) was less than the pure zeolite (369.48 m2/g). It was seen that NCs had a greater asphaltene adsorption capacity and the application of decreasing asphaltene precipitation was higher in comparison to the zeolite nanoparticles. Accordingly, NCs were selected for performing dynamic CO2 tests and investigation of the permeability and porosity reduction parameters at obtained static condition. After adding NCs at the dynamic phase, asphaltene depositions that occured after CO2 injection was decreased and permeability/porosity reduction parameters were improved.
Harmonic balance analysis of magnetically coupled two-degree-of-freedom bistable energy harvesters
Authors: Noh Jinhong , Nguyen Minh Sang , Kim Pilkee , Yoon Yong-Jin 
Published: April 2022

AbstractBecause a magnetically coupled two-degree-of-freedom bistable energy harvester (2-DOF MCBEH) shows the rich, complicated nonlinear behaviors caused by its coupled cubic nonlinearities, understanding the dynamics remains challenging. This paper reports and investigates the important nonlinear dynamical phenomena of the 2-DOF MCBEHs by performing the harmonic balance analysis (HBA). All periodic solution branches are identified in order to study and comprehend the complicated dynamics of the 2-DOF MCBEHs. This end requires care when truncating the harmonic balance solution. For a 1-DOF MCBEH, which is the conventional type, the fundamental harmonic is able to approximately describe the steady-state periodic response. However, high-order harmonics are significant for the 2-DOF MCBEH. This paper demonstrates that the harmonic balance solution should involve the high-order terms instead of using the oversimplified single-harmonic solution. By performing the proposed HBA, important solution branches are reported, and their dynamical behaviors are studied. Moreover, the complete architecture of the frequency response of the 2-DOF MCBEH is disclosed across the entire frequency range. The HBA also reveals the underlying physics of building a bridge between the first and second primary resonant areas under a strong excitation. In the future, the findings in the present report can be utilized in the design process of the 2-DOF MCBEHs.
Low-carbon economic dispatch considering integrated demand response and multistep carbon trading for multi-energy microgrid
Authors: Long Yilin , Li Yong , Wang Yahui , Cao Yijia , Jiang Lin , Zhou Yicheng , Deng Youyue , Nakanishi Yosuke 
Published: April 2022

AbstractWith the rapid development of distributed energy resources and natural gas power generation, multi-energy microgrid (MEMG) is considered as a critical technology to increase the penetration of renewable energy and achieve the target of carbon emission reduction. Therefore, this paper proposes a low-carbon economic dispatch model for MEMG to minimize the daily operation cost by considering integrated demand response (IDR) and multistep carbon trading. Specifically, IDR operation includes shifting of shiftable electric load, adjusting of flexible thermal load and cooling load, and it is employed to decrease operation cost. Besides, the multistep carbon trading means that different carbon trading prices correspond to different carbon trading volumes, which is applied to stringently restrict carbon emission. The simulation results show that the proposed model can effectively reduce the carbon emission while greatly decrease the operation cost.
Temporal reproducibility of IgG and IgM autoantibodies in serum from healthy women
Authors: Clendenen T. V. , Hu S. , Afanasyeva Y. , Askenazi M. , Koenig K. L. , Hulett T. , Liu M. , Liu S. , Wu F. , Zeleniuch-Jacquotte A. , Chen Y. 
Published: April 2022

AbstractAutoantibodies are present in healthy individuals and altered in chronic diseases. We used repeated samples collected from participants in the NYU Women’s Health Study to assess autoantibody reproducibility and repertoire stability over a one-year period using the HuProt array. We included two samples collected one year apart from each of 46 healthy women (92 samples). We also included eight blinded replicate samples to assess laboratory reproducibility. A total of 21,211 IgG and IgM autoantibodies were interrogated. Of those, 86% of IgG (n = 18,303) and 34% of IgM (n = 7,242) autoantibodies showed adequate lab reproducibility (coefficient of variation [CV] < 20%). Intraclass correlation coefficients (ICCs) were estimated to assess temporal reproducibility. A high proportion of both IgG and IgM autoantibodies with CV < 20% (76% and 98%, respectively) showed excellent temporal reproducibility (ICC > 0.8). Temporal reproducibility was lower after using quantile normalization suggesting that batch variability was not an important source of error, and that normalization removed some informative biological information. To our knowledge this study is the largest in terms of sample size and autoantibody numbers to assess autoantibody reproducibility in healthy women. The results suggest that for many autoantibodies a single measurement may be used to rank individuals in studies of autoantibodies as etiologic markers of disease.
Negative affective burden is associated with higher resting-state functional connectivity in subjective cognitive decline
Authors: Schwarz Claudia , Benson Gloria S. , Antonenko Daria , Horn Nora , Köbe Theresa , Klimecki Olga , Sommer Werner , Wirth Miranka , Flöel Agnes 
Published: April 2022

AbstractSubjective cognitive decline (SCD), as expressed by older adults, is associated with negative affect, which, in turn, is a likely risk factor for Alzheimer’s Disease (AD). This study assessed the associations between negative affective burden, cognitive functioning, and functional connectivity in networks vulnerable to AD in the context of SCD. Older participants (60–90 years) with SCD (n = 51) and healthy controls (n = 50) were investigated in a cross-sectional study. Subclinical negative affective burden, quantified through a composite of self-reported negative affective factors, was related to cognitive functioning (self-perceived and objective) and functional connectivity. Seed-to-voxel analyses were carried out in default mode network (DMN) and salience network (SAL) nodes using resting-state functional magnetic resonance imaging. Greater negative affective burden was associated with lower self-perceived cognitive functioning and lower between-network functional connectivity of DMN and SAL nodes in the total sample. In addition, there was a significant moderation of SCD status. Greater negative affective burden related to higher functional connectivity within DMN (posterior cingulate-to-precuneus) and within SAL (anterior cingulate-to-insula) nodes in the SCD group, whereas in controls the inverse association was found. We show that negative affective burden is associated with functional brain alterations in older adults, regardless of SCD status. Specifically in the SCD phenotype, greater negative affective burden relates to higher functional connectivity within brain networks vulnerable to AD. Our findings imply that negative affective burden should be considered a potentially modifiable target for early intervention.
Heat loss augmented by extracorporeal circulation is associated with overcooling in cardiac arrest survivors who underwent targeted temperature management
Authors: Lee Dong Hun , Lee Byung Kook , Cho Yong Soo , Kim Dong Ki , Ryu Seok Jin , Min Jin Hong , Park Jung Soo , Jeung Kyung Woon , Kim Hwa Jin , Youn Chun Song 
Published: April 2022

AbstractWe investigated the association of extracorporeal circuit-based devices with temperature management and neurological outcome in out-of-hospital cardiac arrest survivors who underwent targeted temperature management. Patients with extracorporeal membrane oxygenation and/or continuous renal replacement therapy were classified as the extracorporeal group. We calculated the cooling rate during the induction period and time-weighted core temperatures (TWCT) during the maintenance period. We defined the sum of TWCT above or below 33 °C as positive and negative TWCT, respectively, and the sum of TWCT above 33.5 °C or below 32.5 °C as undercooling or overcooling, respectively. The primary outcome was the negative TWCT. The secondary outcomes were positive TWCT, cooling rate, undercooling, overcooling, and poor neurological outcomes, defined as Cerebral Performance Category 3–5. Among 235 patients, 150 (63.8%) had poor neurological outcomes and 52 (22.1%) were assigned to the extracorporeal group. The extracorporeal group (β, 0.307; p < 0.001) had increased negative TWCT, rapid cooling rate (1.77 °C/h [1.22–4.20] vs. 1.24 °C/h [0.77–1.79]; p = 0.005), lower positive TWCT (33.4 °C∙min [24.9–46.2] vs. 54.6 °C∙min [29.9–87.0]), and higher overcooling (5.01 °C min [0.00–10.08] vs. 0.33 °C min [0.00–3.78]). However, the neurological outcome was not associated with the use of extracorporeal devices (odds ratio, 1.675; 95% confidence interval, 0.685–4.094).
Sexually dimorphic peripheral sensory neurons regulate copulation duration and persistence in male Drosophila
Authors: Jois Shreyas , Chan Yick-Bun , Fernandez Maria Paz , Pujari Narsimha , Janz Lea Joline , Parker Sarah , Leung Adelaine Kwun-Wai 
Published: April 2022

AbstractPeripheral sensory neurons are the gateway to the environment across species. In Drosophila, olfactory and gustatory senses are required to initiate courtship, as well as for the escalation of courtship patterns that lead to copulation. To be successful, copulation must last long enough to ensure the transfer of sperm and seminal fluid that ultimately leads to fertilization. The peripheral sensory information required to regulate copulation duration is unclear. Here, we employed genetic manipulations that allow driving gene expression in the male genitalia as a tool to uncover the role of these genitalia specific neurons in copulation. The fly genitalia contain sex-specific bristle hairs innervated by mechanosensory neurons. To date, the role of the sensory information collected by these peripheral neurons in male copulatory behavior is unknown. We confirmed that these MSNs are cholinergic and co-express both fru and dsx. We found that the sensory information received by the peripheral sensory neurons from the front legs (GRNs) and mechanosensory neurons (MSNs) at the male genitalia contribute to the regulation of copulation duration. Moreover, our results show that their function is required for copulation persistence, which ensures copulation is undisrupted in the presence of environmental stress before sperm transfer is complete.
Peanut (Arachis hypogaea) sprout prevents high-fat diet-induced cognitive impairment by improving mitochondrial function
Authors: Park Seon Kyeong , Lee Hyo Lim , Kang Jin Yong , Kim Jong Min , Heo Ho Jin 
Published: April 2022

AbstractThis study was performed to evaluate the improvement effect of the ethyl acetate fraction from peanut (Arachis hypogaea) sprout (EFPS) on high-fat diet (HFD)-induced cognitive deficits in C57BL/6 mice. Mice were randomly divided four groups (n = 13) as control (normal chow), HFD, EFPS 20 (20 mg/kg of body weight; intragastric administration) and EFPS 50 (50 mg/kg of body weight; intragastric administration) groups. HFD was provide for 15 weeks excepting control group. EFPS ameliorated cognitive dysfunction in Y-maze, passive avoidance test and Morris water maze test. EFPS significantly improved glucose tolerance and serum lipid profile, and reduced body weight. EFPS ameliorated oxidative stress by regulating MDA levels and SOD activity in liver and brain tissues. In addition, EFPS restored brain mitochondrial dysfunction related to energy metabolism. Moreover, the bioactive compounds of EFPS were identified as di-caffeic acid, caffeic acid, dihydrokaempferol-hexoside, di-p-coumaroyl tartaric acid isomer and group B soyasaponins using ultra-performance liquid chromatography-quadrupole-time-of-flight (UPLC-Q-TOF) mass spectrometry. These results show that EFPS can improve cognitive functions in HFD-induced diabetic mice.