bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análisis de la productividad total de los factores en Colombia (1950-2017)
Authors: Castellano Montiel Alberto Gregorio , Orozco Suárez Andrés Felipe 
Published: June 2022

El presente artículo estima la productividad total de los factores (PTF) para Colombia, aplicando el modelo Solow-Swan ampliado en el período 1950-2017, a partir de un análisis de cointegración y un vector de corrección de errores (VEC). Los resultados evidencian que la PTF para el período de estudio es del 0.13 %; finalmente, se tiene que la PTF no explica el proceso de crecimiento en Colombia tomando en consideración un modelo neoclásico.
Aceclofenac, a Preferential COX-2 Inhibitor - Appraisal of Safety and Tolerability
Authors: Anu Grover  , Eknath Pawar  , G. K. Singh  , Ashok Gupta  , Anil Pareek  , Rujul Desai  , Indranil Purkait  
Published: June 2022

BACKGROUND
Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used medications to reduce inflammation and pain in clinical practice. The main concern with their use is gastrointestinal and cardiovascular side effects due to inhibition of gastroprotective prostaglandins and imbalance of prostacyclin and thromboxane respectively. NSAIDs function by inhibiting the cyclooxygenase (COX) enzymes. Evidence shows the occurrence of these side effects even with their short term use. Development of NSAID with a goal of superior or similar efficacy but with lower incidences of side effects resulted in the introduction of aceclofenac. Classified as a preferential COX-2 inhibitor, aceclofenac inhibits the COX-2 enzyme preferentially (97 %) as compared to COX-1 (46 %). Lesser inhibition of the COX-1 enzyme results in lower incidences of GI side effects. Also, due to preferential COX-2 selectivity, aceclofenac balances vascular homeostasis and thus has minimal CV risk. The diversity of COX-1 and COX-2 selectivity in NSAIDs has proven clinically important. Encouraging clinical evidence shows that aceclofenac has a favourable safety profile amongst NSAIDs. Our goal in this manuscript is to give a narrative review of clinical evidence of aceclofenac’s safety and tolerability. Based on the data, we can conclude that aceclofenac is an effective analgesic in both acute and chronic inflammatory conditions, with a comparatively low risk of gastrointestinal and cardiovascular adverse effects. This favourable tolerability profile of the drug reflects a reduction in cost associated with adverse events management, from both patient’s and healthcare provider’s perspectives.
Hidden Environmental Impact of COVID-19 Vaccination: Waste Management, Treatment, and Global Warming Potential
Authors: Septiariva Iva Yenis , Sarwono Ariyanti , Suryawan I Wayan Koko 
Published: June 2022

Latar belakang: Indonesia, negara terpadat keempat di dunia, muncul sebagai episentrum Covid-19 di Asia pada pertengahan tahun 2021. Lonjakan kasus COVID19 mendorong negara untuk menargetkan 1 juta vaksinasi Covid-19 per hari.Metode: Penelitian ini menggunakan data kualitatif dari tinjauan pustaka sebelumnya kemudian diolah menggunakan perhitungan yang sesuai dengan metode pengelolaan limbah vaksin.Hasil: Meskipun peluncuran vaksinasi besar-besaran, dampaknya terhadap lingkungan masih dipertanyakan. Tidak hanya pembuangan limbah medis yang tidak tepat tetap menjadi tantangan sejak wabah pandemi pada tahun 2020, tetapi vaksinasi memperburuk keadaan. Selain limbah padat, konsumsi listrik dan emisi polutan dari zat pendingin mungkin berkontribusi terhadap jejak karbon yang tinggi.Simpulan: Makalah ini menyoroti pentingnya pengelolaan limbah selama Covid-19 dan konsekuensi tak terduga pada penyimpanan dan penanganan vaksin untuk pengambilan keputusan peluncuran vaksinasi lebih lanjut. ABSTRACT Background: Indonesia, the world’s fourth most populous country, emerged as Asia's Covid-19 epicenters in the mid of 2021. The surge in COVID19 cases drives the nation to aim for 1 million Covid-19 vaccinations per day. Method: This study uses qualitatively and quantitatively data from previous literature reviews and then processed using calculations that are in accordance with the vaccine waste management method.Result: Despite massive vaccination rollout, the impact on the environment is still in question. Not only has improper medical waste disposal remained a challenge since the pandemic breakout in 2020, but the vaccination worsened the circumstances. In addition to solid waste, the electricity consumption and pollutant emissions of the refrigerants might contribute to a high carbon footprint. Conclusion: This paper highlights the importance of waste management during Covid-19 and unforeseen consequences on vaccine storage and handling for decision making of further vaccination rollouts.
Estimates for weighted Ostrowski–Grüss type inequalities with applications
Authors: Shaikh Muhammad Awais , Khan Asif R. , Mehmood Faraz 
Published: June 2022

Abstract
In the present paper, some error bounds for weighted Ostrowski–Grüss type inequalities are found by using the weighted Čebyšev functional and Diaz–Metcalf inequality. These bounds give some better and new estimates. Applications are also obtained for numerical integration. Furthermore, this paper recaptures some previous established results as its special cases.
She, he, not it: Language, personal pronouns, and animal advocacy
Authors: Merskin Debra 
Published: June 2022

Abstract
The move away from binary labels of he/she as all-encompassing terms, determined at birth, represents a tidal change in how humans are categorized. However, when it comes to animals other than humans, change appears only as drops in the linguistic bucket with slow progress in recognizing them as individuals, who are sexed, and whose treatment by us is determined by which sex they are assigned at birth. Language that continues to refer to them as “it”, for example, rather than “he” or “she” (when sex is known), and not as “they” when it is not, concretizes living beings in the category of object, not subject. This article discusses language as power and focuses on how language matters in the lives of animals other than humans. There is a brief discussion about the creation of animalsandmedia.org. This website is discussed in terms of what informed its creation, what fuels its maintenance, and finally, a media example that shows what using personal pronouns looks like, breaking with style recommendations. How we refer to animals does not reflect who they are, but rather who we are. This matters not only in the categorization and subsequent treatment of animals but also in broader ecological domains and well-being.
Spontaneous pain as a challenge of research and management in chronic pain
Authors: Ma Longyu , Liu Shuting , Yi Ming , Wan You 
Published: June 2022

Abstract
Spontaneous pain occurring without apparent external stimuli, is a significant complaint of individuals with chronic pain whose mechanisms, somewhat surprisingly, remain poorly understood. Over the past decades, neuroimaging studies start to reveal brain activities accompanying spontaneous pain. Meanwhile, a variety of animal models and behavioral tests have been established, including non-reflexive tests and free-choice tests, which have been shown to be effective in assessing spontaneous pain. For the spontaneous pain mechanisms, multiple lines of research mainly focus on three aspects: (1) sensitization of peripheral nociceptor receptors and ion channels, (2) spontaneous neuronal firing and abnormal activity patterns at the dorsal root ganglion and spinal cord level, (3) functional and structural alterations in the brain, particularly the limbic system and the medial pain pathway. Despite accumulating evidence revealing distinct neuronal mechanisms from evoked pain, we are still far from full understanding of spontaneous pain, leaving a big gap between bench and bedside for chronic pain treatment. A better understanding of the neural processes in chronic pain, with specific linkage as to which anatomical structures and molecules related to spontaneous pain perception and comorbidities, will greatly improve our ability to develop novel therapeutics.
New Development Theory on Measure Pseudo – Asymptotically Omega Periodic Functions
Authors: Dads E. Ait , Lhachimi L. 
Published: June 2022

Abstract
The main goal of the paper concerns two parts, in the ˝rst one, we extend some results from Blot et al [5] under general hypothesis on the measure, in the second part, we introduce a new class of functions, which we call measure pseudo 𝒮 - asymptotically omega periodic functions. The obtained results is the extension of those established recently in the literature. Then we establish many interesting results on those functions, namely their characterization, we give also several properties of those class of functions as composition results, the invariance by translation, and the convolution product. All sections are illustrated by examples or counter examples.
The effect of long-term exposure to toxic air pollutants on the increased risk of malignant brain tumors
Authors: Nikmanesh Yousef , Mohammadi Mohammad Javad , Yousefi Homayon , Mansourimoghadam Sara , Taherian Masoume 
Published: June 2022

AbstractToxic air pollutants are one of the most agent that have many acute, chronic and non-communicable diseases (NCDs) on human health under long or short-term exposure has been raised from the past to the present. The aim of this study was investigation effect of long-term exposure to toxic air pollutants on the increased risk of malignant brain tumors. Databases used to for searched were the PubMed, Web of Science, Springer and Science Direct (Scopus) and Google Scholar. 71 papers based on abstract and article text filtered. In the end after sieve we selected 7 papers. Identify all relevant studies published 1970–2022. The literature showed that exposure to toxic air pollutants and their respiration can cause disorders in different parts of the brain by transmission through the circulatory system and other mechanisms. Various unpleasant abnormalities are caused by the inhalation of toxic air pollutants in the human body that some of the most common of them include chronic lung disease, coronary heart disease and heart attacks, strokes and brain diseases (Parkinson’s, Alzheimer’s and multiple Sclerosis), cancers (liver, blood, prostate and brain) and eventually death. According to the finding brain health and proper functioning can be easily disrupted by various genetic or external factors such as air pollution, causing a wide range of abnormalities in the brain and malignant brain tumors. The results of this study showed that reducing the concentration of toxic pollutants in the air, that exposure to them play an increasing role in the development of brain diseases can slow down the process of abnormalities in the brain and will have significant impacts on reducing the number of people affected by them.
Religiöse Voraussetzungen für Spiritual Care? Eine semiotische Verhältnisbestimmung
Authors: Böckel Holger 
Published: June 2022

ZusammenfassungReligiöse Voraussetzungen für Spiritual Care sind durch die drei Grundformen von Spiritualität nach religiöser Deutungsdichte (nicht-, mittel- und hochreligiös) bestimmbar, denn sie bestehen in einer entsprechenden Deutungskompetenz und können hinsichtlich der Realisierung religiöser Deutung in diesen drei Grundformen semiotisch analysiert werden. Dabei korrelieren mit den drei Grundformen von Spiritualität erst-, zweit- und drittheitliche Zeichen- und Objektbezüge bzw. Bezüge der Interpretantenbildung im Rahmen des kreativen Prozesses der Entstehung von religiöser Bedeutung („Abduktion“ nach C. S. Peirce).Die „Anamnese“ im Zuge von Spiritual Care sollte zunächst im Sinne einer spirituellen Wahrnehmungskompetenz die jeweilige Grundform der Spiritualität aufnehmen. Spiritual Care-Tätige werden so in die Lage versetzt, die i. e. S. religiösen Voraussetzungen von Deutungsprozessen des Gegenübers mit der eigenen religiösen Deutungs- und Erschließungskompetenz abzugleichen. Spezifisch religiöse Deutungs- und Erschließungskompetenzen sind als Voraussetzung für Spiritual Care stets angezeigt, wenn dem Gegenüber eine hochreligiöse Form von Spiritualität im Rahmen der mit diesen Kompetenzen korrelierenden Religionsgemeinschaft eigen ist („Drittheitlichkeit“). Darüber hinaus kommen diese immer dann in den Blick, wenn durch eine vorliegende Fragestellung dementsprechend weitergehende religiöse Deutungsmuster nahe liegen.
Green synthesis of iron nanoparticles and photocatalytic activity evaluation for the degradation of methylene blue dye
Authors: Bibi Ismat , Ghulam Tahir , Kamal Shagufta , Jilani Kashif , Alwadai Norah , Iqbal Munawar 
Published: June 2022

Abstract
The present study focuses on iron nanoparticles (Fe NPs) biosynthesis, characterization and photocatalytic activity (PCA) appraisal for methylene blue dye degradation. A green rapid biogenic synthesis route was employed for synthesis of Fe NPs using banana peel extract. The synthesized Fe NPs was characterized by XRD (X-ray diffraction), SEM (scanning electron microscopy) and EDX (energy dispersive X-ray) techniques. These analysis confirmed the synthesis of zero valent Fe NPs with high crystallinity, purity and semi spherical in shape. The photocatalytic activity was assessed under ultra violet irradiation and under optimum conditions, 87% degradation of MB dye was obtained for 72 min of irradiation, which revealed promising catalytic efficiency of the Fe NPs. The result shows that photocatalytic activity of Fe NPs is promising and could possibly be used to treat dyes in industrial effluents and the use of green synthetic protocol is suggested due to its ecofriendly nature.
A heterotypic assembly mechanism regulates CHIP E3 ligase activity
Authors: Das Aniruddha , Thapa Pankaj , Santiago Ulises , Shanmugam Nilesh , Banasiak Katarzyna , Dąbrowska Katarzyna , Nolte Hendrik , Szulc Natalia A , Gathungu Rose M , Cysewski Dominik , Krüger Marcus , Dadlez Michał , Nowotny Marcin , Camacho Carlos J , Hoppe Thorsten , Pokrzywa Wojciech 
Published: June 2022

AbstractCHIP (C‐terminus of Hsc70‐interacting protein) and its worm ortholog CHN‐1 are E3 ubiquitin ligases that link the chaperone system with the ubiquitin‐proteasome system (UPS). CHN‐1 can cooperate with UFD‐2, another E3 ligase, to accelerate ubiquitin chain formation; however, the basis for the high processivity of this E3s set has remained obscure. Here, we studied the molecular mechanism and function of the CHN‐1–UFD‐2 complex in Caenorhabditis elegans. Our data show that UFD‐2 binding promotes the cooperation between CHN‐1 and ubiquitin‐conjugating E2 enzymes by stabilizing the CHN‐1 U‐box dimer. However, HSP70/HSP‐1 chaperone outcompetes UFD‐2 for CHN‐1 binding, thereby promoting a shift to the autoinhibited CHN‐1 state by acting on a conserved residue in its U‐box domain. The interaction with UFD‐2 enables CHN‐1 to efficiently ubiquitylate and regulate S‐adenosylhomocysteinase (AHCY‐1), a key enzyme in the S‐adenosylmethionine (SAM) regeneration cycle, which is essential for SAM‐dependent methylation. Our results define the molecular mechanism underlying the synergistic cooperation of CHN‐1 and UFD‐2 in substrate ubiquitylation.
Mitochondrial respiration in thoracic perivascular adipose tissue of diabetic mice
Authors: Pinho Aryane Cruz Oliveira , Santos Diana , Baldeiras Inês , Burgeiro Ana , Leal Emelindo C , Carvalho Eugenia 
Published: June 2022

Introduction
Thoracic perivascular adipose tissue (tPVAT) has a phenotype resembling brown AT. Dysfunctional tPVAT appears to be linked to vascular dysfunction.

Methods
We evaluated uncoupling protein 1 (UCP1) expression by Western blot, oxidative stress by measuring lipid peroxidation, the antioxidant capacity by HPLC and spectrophotometry, and mitochondrial respiration by high-resolution respirometry (HRR) in tPVAT, compared to inguinal white AT (iWAT), obtained from non-diabetic (NDM) and streptozocin-induced diabetic (STZ-DM) mice. Mitochondrial respiration was assessed by HRR using protocol 1: complex I and II oxidative phosphorylation (OXPHOS) and protocol 2: fatty acid oxidation (FAO) OXPHOS. OXPHOS capacity in tPVAT was also evaluated after UCP1 inhibition by guanosine 5'-diphosphate (GDP).

Results
UCP1 expression was higher in tPVAT when compared with iWAT in both NDM and STZ-DM mice. The malondialdehyde concentration was elevated in tPVAT from STZ-DM compared to NDM mice. Glutathione peroxidase and reductase activities, as well as reduced glutathione levels, were not different between tPVAT from NDM and STZ-DM mice but were lower compared to iWAT of STZ-DM mice. OXPHOS capacity of tPVAT was significantly decreased after UCP1 inhibition by GDP in protocol 1. While there were no differences in the OXPHOS capacity between NDM and STZ-DM mice in protocol 1, it was increased in STZ-DM compared to NDM mice in protocol 2. Moreover, complex II- and FAO-linked respiration were elevated in STZ-DM mice under UCP1 inhibition.

Conclusions
Pharmacological therapies could be targeted to modulate UCP1 activity with a significant impact in the uncoupling of mitochondrial bioenergetics in tPVAT.
Characteristics of Emergency Room and Hospital Encounters Resulting From Consumer Home Monitors
Authors: Craig Sansanee , Rasooly Irit R. , Kern-Goldberger Andrew S. , Luo Brooke , Mai Mark V. , Beus Jonathan M. , Faulkenberry J. Grey , Brent Canita , Herchline Daniel , Muthu Naveen , Bonafide Christopher P. 
Published: June 2022

BACKGROUND AND OBJECTIVES
Consumer home monitors (CHM), which measure vital signs, are popular products marketed to detect airway obstruction and arrhythmia. Yet, they lack evidence of infant death prevention, demonstrate suboptimal accuracy, and may result in false alarms that prompt unnecessary acute care visits. To better understand the hospital utilization and costs of CHM, we characterized emergency department (ED) and hospital encounters associated with CHM use at a children’s hospital.

METHODS
We used structured query language to search the free text of all ED and admission notes between January 2013 and December 2019 to identify clinical documentation discussing CHM use. Two physicians independently reviewed the presence of CHM use and categorized encounter characteristics.

RESULTS
Evidence of CHM use contributed to the presentation of 36 encounters in a sample of over 300 000 encounters, with nearly half occurring in 2019. The leading discharge diagnoses were viral infection (13, 36%), gastroesophageal reflux (8, 22%) and false positive alarm (6, 17%). Median encounter duration was 20 hours (interquartile range: 3 hours to 2 days; max 10.5 days) and median cost of encounters was $2188 (interquartile range: $255 to $7632; max $84 928).

CONCLUSIONS
Although the annual rate of CHM-related encounters was low and did not indicate a major public health burden, for individual families who present to the ED or hospital for concerns related to CHMs, there may be important adverse financial and emotional consequences.
STRATEGI PENGHIDUPAN BERKELANJUTAN PADA KOMUNITAS PENGOLAH IKAN DI MASA PANDEMI COVID 19 (Studi Kasus Di Kalurahan Poncosari, Kepanewon Srandakan, Bantul)
Authors: Setyaningrum Agustina , Nugroho Agung Satriyo 
Published: June 2022

The fish processing community in Kuwaru Beach experienced some production problems during the Covid 19 pandemic. This study aims to identify livelihoods and community livelihood strategies during the pandemic. This research is qualitative. The data collected are secondary data and primary data. Primary data were taken through observation, in-depth interviews, and documentation. Secondary data was taken through a literature review. The results showed that the community had good physical capital. Social capital, human capital, and natural capital are in the moderate. Meanwhile, financial capital is relatively low. They have difficulty accessing capital and do not have the requirements. No migration strategy was found in livelihoods. They carry out extensification and intensification strategies to maintain production activities
La lectura literaria como experiencia en niños hospitalizados del pabellón de oncología del Hospital Universitario de Santander (HUS)
Authors: Gómez Rodríguez Jhonatan Fabián 
Published: June 2022

En el presente artículo se comparten los resultados de una investigación cuyo objetivo central fue promover experiencias de lectura, a través de literatura infantil y juvenil, en niños/as-pacientes hospitalizados en el Servicio de Pediatría (sección oncología) del Hospital Universitario de Santander (HUS). Metodológicamente, esta investigación se sustentó en los estudios de caso (Páramo, 2013) y la investigación-acción (Elliot, 1996), a través de técnicas e instrumentos como la observación participativa, la entrevista semiestructurada de tipo de contacto alto y cuestionarios de tipo personal. Por otro lado, teóricamente, este trabajo se fundamentó a partir de: a) los aportes sobre la experiencia de la lectura, su mediación y las teorías acerca de la literatura infantil y juvenil (LIJ), b) la pedagogía hospitalaria y c) la biblioterapia.
Entre los resultados más relevantes, se destaca la importancia de la lectura en contextos hospitalarios infantiles no sólo como actividad de ocio/uso del tiempo libre, sino también como una forma de apoyo psicoemocional para los niños/as-pacientes en condiciones de vulnerabilidad, al observar cambios emocionales significativos en los participantes antes, durante y después de cada sesión de lectura. De igual forma, se subraya el rol sustancial de las figuras paternas/maternas como acompañantes de los niños/as-pacientes durante el proceso lector. Por último, se revelan las temáticas y los libros infantiles que tuvieron más aceptación en los pacientes participantes, el porqué de esta aceptación y cómo dichas temáticas/libros contribuyeron a mejorar la experiencia hospitalaria de enfermedad y convalecencia en el aspecto psicoemocional de los pacientes.