bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Clinical Pharmacist-physician Communication on Reducing Drug-related Problems: a RCT in a Tertiary Teaching Hospital in Xinjiang, China
Authors: Zheng Feiyang , Wang Dan , Zhang Xinping 
Published: June 2022

Abstract
BackgroundThe incidence of drug-related problems (DRP) has caused serious health hazards and economic burdens among poly-medicine patients. Effective communication between clinical pharmacists and physicians (CPP) has a significant impact on reducing DRPs, but evidence is poor.MethodsA semi-structured interview was conducted to explore the communication mode between CPPs based on the interprofessional approach of the shared decision making model and Relational Coordination theory. A randomized controlled trial (RCT) was used to explore the effects of communication intervention on reducing DRPs. Logistic regression analysis was used to identify the influencing factors of communication.ResultsThe mode of communication is driven by clinical pharmacists between CPPs and selectively based on different DRP types. Normally, the communication contents only cover two (33.8%) types of DRP contents or fewer (35.1%). The communication time averaged 5.8 minutes. The communication way is predominantly face-to-face (91.3%), but telephone or other online means (such as WeChat) may be preferred for urgent task or long physical distance. Among the 367 participants, 44 patients had DRPs. RCT results indicated a significant difference in DRP incidence between the control group and the intervention group after the communication intervention (P = 0.02), and the incidence of DRP in the intervention group was significantly reduced (15.6% vs 0.07%). Regression analysis showed that communication time had negative impact on DRP incidence (OR = 13.22, p < 0.001).ConclusionFace-to face communication is mainly current practiced mode between CPPs, but they communicate few contents when dealing with DRPs. Communication mode based on the interprofessional approach of the shared decision making between CPPs in medication decision-making could significantly reduce the incidence of DRP and the length of communication time is a significant factor. The longer the communication time, the fewer DRPs occur.Trial registration:This trial was approved by the ethics committee of The First Affiliated Hospital of Medical College of Xinjiang Shihezi University Hospital (kj2020-087-03) and registered in the China clinical trial registry (https:// www.chictr.org.cn, number ChiCTR2000035321 date: 08/08/2020).
Is Globalization Driving the Use of Renewable Energy? A Global Macro Perspective
Authors: Salman Verda , Ahmad Imtiaz , Alvi Shahzad 
Published: June 2022

Abstract

The contemporary world has become increasingly interdependent in terms of economic, social and political development. These various forms of interdependence, usually termed globalization, help disseminate ideas, information, products, and services around the world. Increase in globalization has also increased path-dependence, affecting economic, social, and institutional development and completing some industries, products and technologies to grow in line with the global demand and changing standards. While the role of globalization in economic growth, technology transfer and institutional development is established in literature, the role of globalization in reversing environmental deterioration is not explored yet. The current study looks at how globalization has affected renewable energy use in high, upper middle and lower middle income countries. The empirical results based on a fixed effects model show that countries differ in terms of taking advantage of different types of globalization, i.e., economic, social and political, while transitioning towards renewable energy (RE) projects. Economic globalization has a positive influence on RE usage in the case of high and lower middle income countries, Social globalization in case of high and upper middle income countries. Contrary to the positive impacts of economic and social globalization, political globalization has a negative impact on RE usage in the case of high income countries. In addition to globalization, the effect of government effectiveness, GDP per capita and CO2 vary across the groups of countries.
Experience with the Tecnis Symfony Extended Range of Vision IOL in Patients with Pre- existing Retinal Pathology
Authors: Odette John , Nguyen David , Morrisette Amanda 
Published: June 2022

Abstract
Background: There are limited publications about multifocal IOLs and patients with pre-existing retinal pathologies. Published outcomes have been mixed, with some showing good visualization of the retina postoperatively, while others report difficulty with visualization of the retina through MIOL. This study evaluated outcomes with TECNIS Symfony® Extended Range of Vision IOL (Symfony) in patients with and without pre-existing retinal pathology.Methods: Visual acuity (VA) was retrospectively evaluated for patients who underwent cataract surgery with implantation of the Symfony IOL from 09/1/2016 to 05/31/2018 at a single, US clinical site. Month 2 postoperative outcomes were compared for eyes with (70 eyes) and without pre-existing retinal pathology (616 eyes). Outcomes included mean monocular uncorrected visual acuity (±SD) at near (UNVA) at 40 cm, far distance (UDVA) at 20 ft, and with best correction (CDVA).Results: UNVA was 0.07 ± 0.10 logMAR in the non-pathology eyes vs. 0.17 ± 0.20 logMAR in eyes with pathology (p<0.0001). Mean monocular UDVA was 0.11 ± 0.90 logMAR in the non-pathology eyes vs. 0.21± 0.19 logMAR in eyes with pathology (p<0.0001). Mean monocular CDVA was 0.02 ± 0.06 logMAR in the non-pathology eyes vs. 0.11± 0.17 logMAR in eyes with pathology (p<0.0001). Eyes with mild to moderate pathology had VA comparable with non-pathology eyes.Conclusion: In this retrospective review, the Symfony IOL provided good uncorrected and best-corrected visual acuity at near and far distances in eyes with and without retinal pathology. Trial Registration: NCT05111106 (clinicaltrials.gov)
Finding stable multi-component materials by combining cluster expansion with crystal structure predictions
Authors: Carlsson Adam , Rosen Johanna , Dahlqvist Martin 
Published: June 2022

Abstract
A desired prerequisite when performing a quantum mechanical calculation is to have an initial idea of the atomic positions within an approximate crystal structure. The atomic positions combined should result in a system located in, or close to, an energy minimum. However, designing low-energy structures may be challenging when prior knowledge is scarce, specifically for large multi-component systems where the degrees of freedom are close to infinite. In this paper we propose a method for identification of low-energy crystal structures in multi-component systems by combining cluster expansion and crystal structure prediction with density functional theory calculations. More importantly, we show that employing seed structures retrieved from cluster expansion models may significantly reduce the number of generations needed within the computationally demanding crystal structure prediction methodology. With this combined approach, we correctly identified the recently discovered Mo4/3Sc2/3AlB2 i-MAB phase comprised of in-plane chemical ordering of Mo and Sc and with Al in a Kagomé lattice. This result demonstrates that a combined approach provides a path for identifying low-energy crystal structures in multi-component systems by employing the strengths from both the cluster expansion method and the crystal structure prediction framework. In addition, we also address examples when cluster expansion fails to account for important structural transformations in sublattices not part of the parametrization.
Comprehensive Analysis of HNRNPR in ESCA and its High Expression Combined with 18F-FDG PET/CT Metabolic Parameters as a Novel Biomarker for ESCA Preoperative Diagnosis
Authors: Liu Xiao-Yu , Gao Yan , Kui Xue-Yan , Liu Xu-Sheng , Zhang Yao-hua , Zhang Yu , Ke Chang-Bin , Pei Zhijun 
Published: June 2022

Abstract
Background
The purpose of this study was to determine the expression and function of heterogeneous nuclear ribonucleoprotein R (HNRNPR) in esophageal carcinoma (ESCA), the correlation between its expression and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computerized tomography scan (PET/CT)-related parameters, as well as whether 18F-FDG PET/CT can be used to predict the expression of HNRNPR in ESCA.
Methods
We analyzed patients with ESCA who underwent 18F-FDG PET/CT before surgery, and their tissues were stained with HNRNPR IHC. The associated parameters were derived using the 18F-FDG PET imaging data, and the correlation with the IHC score was evaluated. The Oncomine, TCGA, and GEO datasets were used to investigate HNRNPR expression in the pan- and esophageal cancers, as well as its relationship to N6-methyladenosine (m6A) modification and glycolysis. The R software, LinkedOmics, GeneMANIA, and StringOnline tools were used to perform GO/KEGG, GGI, and PPI analyses on the HNRNPR.
Results
HNRNPR is highly expressed in the majority of pan-cancers, including ESCA, and is associated with BMI, weight, and history of reflux in patients with ESCA. HNRNPR is somewhat accurate in predicting the clinical prognosis of ESCA. HNRNPR expression was positively correlated with SUVmax, SUVmean, and TLG in ESCA (p༜0.05). The combination of these three variables provides a strong predictive value for HNRNPR expression in ESCA. GO/KEGG analysis showed that HNRNPR was related to the cell cycle, DNA replication, and the Fannie anemia pathway. The analysis of the TCGA and GEO data sets revealed a significant correlation between HNRNPR expression and m6A and glycolysis-related genes. GSEA analysis revealed that HNRNPR was involved in a variety of m6A and glycolysis related-pathways.
Conclusion
HNRNPR overexpression correlates with 18F-FDG uptake in ESCA, probably by regulating cell cycle, m6A modification and cell glycolysis. 18F-FDG PET/CT-related parameters may estimate HNRNPR expression for diagnostic accuracy and biomarker of ESCA.
Survival of natural glass under hyperalkaline conditions for ~4000 years
Authors: Kikuchi Ryosuke , Sato Tsutomu , Fujii Naoki , Shimbashi Misato , Arcilla Carlo A. 
Published: June 2022

Abstract
Silicate glasses are durable materials in our daily life, but corrosion rate accelerates under alkaline aqueous environment. Such situation has raised concerns, for example, in nuclear waste disposal where vitrified wastes encounter to alkaline leachate from surrounding concrete materials. Here we report volcanic glass example surviving with a hyperalkaline groundwater (pH > 11) and high flow rate for about 4000 years. The tiny glass fragments were extracted from the volcanic ash layer sandwiched between ultramafic sediments using microanalytical techniques. Sharp elemental distributions at the glass surface, where amorphous-like smectite precursors and crystalline smectites coexist, suggest the corrosion by an interface-coupled dissolution-precipitation mechanism rather than inter-diffusion. The secondary minerals acted as a protective film for the glass by limiting water accessibility. The corrosion rate was maintained at, the minimum, 2.5 orders of magnitude less than the rate observed for fresh glass, even in the presence of Fe and Mg that might have consumed Si through the silicate precipitation.
TROP-2 expression in triple-negative breast cancer: correlations with tumor-infiltrating lymphocytes, histological subtypes and survival
Authors: Izci Hava , Punie Kevin , Waumans Lise , Laenen Annouschka , Wildiers Hans , Verdoodt Freija , Desmedt Christine , Ardui Jan , Smeets Ann , Han Sileny N. , Nevelsteen Ines , Neven Patrick , Floris Giuseppe 
Published: June 2022

Abstract
BackgroundLimited data exist regarding the associations between TROP-2 protein expression, clinicopathological characteristics, and outcome in triple-negative breast cancer (TNBC). MethodsTROP-2 expression was determined for patients diagnosed with TNBC between 2000-2017 by immunohistochemistry (IHC) (ab227689, Abcam) on whole slide tumor sections, and assessed as continuous and categorical variables (H-score high, 201-300, medium 100-200 and low <100). Associations between TROP-2 expression and age, BMI, tumor grade and size, lymphovascular invasion (LVI), ductal carcinoma in situ (DCIS) presence, nodal status, stromal tumor-infiltrating lymphocytes (sTILs), androgen receptor (AR), standardized mitotic index (SMI), and outcome were assessed. ResultsWe included 685 patients with a median age at diagnosis of 54y (range 22-90y). TROP-2 expression was high, medium and low in 97 (16.5%), 149 (25.3%) and 343 (58.2%) of patients, respectively. The presence of LVI, associated DCIS, nodal involvement, apocrine histology and AR expression were correlated with higher TROP-2 levels. TROP-2 was not associated with pathological complete response (pCR). There were no associations between TROP-2 expression and time-to-event outcomes. ConclusionsIn stage 1-3 TNBC, higher TROP-2 expression was correlated with apocrine histology, higher AR expression, presence of DCIS, LVI, and nodal involvement. There was no correlation between TROP-2 expression and sTILs or outcome.
Relationships between available-holding water capacity, N-NO3- and K in the soil with parameters of nutritional status, vigour, yield, must and wine composition in the cv. Tempranillo
Authors: Martínez-Vidaurre José María , Pérez-Álvarez Eva Pilar , García-Escudero Enrique , Peregrina Fernando 
Published: June 2022

Abstract
Purpose
The aim of this study was to assess the relationship between the available water-holding capacity (AWC), available N-NO3− and K extractable content in the soil and the vine nutritional status, vigour, yield and quality of the musts and wines in D.O.Ca. Rioja vineyards over a period of five years (2010–2014).
Methods
The AWC, available N-NO3− and K extractable contents in the soil were analysed in twelve cv. Tempranillo plots. Vine yield and nutritional parameters were determined, as well as the K and polyphenols compounds in the musts and wines.
Results
In general, both the AWC and the N-NO3− content correlated positively with the N and K content of the petiole, the shoot weight, and the bunch weight, but negatively with the polyphenols and anthocyanins content of the musts and wines. The K that can be extracted from the soil also correlated with the K content of the petiole, and with the K in the musts and wines.
Conclusions
The AWC, the N-NO3− and the extractable K are soil parameters which have been linked to the growth and ripening of the vine plant, as well as to the composition of the must and wine. For D.O.Ca. Rioja wine-growing sector, these soil parameters would be a suitable tool in order to select soils that allow to obtain wines of better quality.
Exploring the Contributions of Affective Constructs and Interoceptive Awareness to Feeling Fat
Authors: Morales Cate , Dolan Sarah C. , Anderson Drew A. , Anderson Lisa M. , Reilly Erin E 
Published: June 2022

Abstract
Purpose
Feeling fat, a subjective feeling of being overweight that does not correspond with body weight, is commonly-reported in patients with eating disorders (EDs). Research suggests that feeling fat relates to deficits in interoceptive awareness (IA), the perception and integration of signals related to body states. Relatedly, recent work has linked feeling fat to affective constructs, such as depressive symptoms and guilt. The current study explores the unique relationships between feeling fat, self-reported and objective IA, guilt, alexithymia, and depressive symptoms.
Method
Female undergraduates (N = 128) completed the 11th item of the Eating Disorder Examination Questionnaire, the Toronto Alexithymia Scale, the Guilt subscale of the Positive and Negative Affect Schedule, and the Beck Depression Inventory-II. Participants also completed two IA measures: a heartbeat perception task and the Multidimensional Assessment of Interoceptive Awareness.
Results
Results indicated that all collected measures explained 56% of the variability in feeling fat. Depressive symptoms, self-reported IA, and BMI accounted for significant variability in feeling fat. Relative weights analyses revealed that depressive symptoms accounted for the most variability in feeling fat.
Conclusions
Our results replicate previous findings that depressive symptoms relate significantly to feeling fat and extend this work by suggesting that, for ED patients with interoceptive deficits, depressed affective states contribute to feeling fat. Clarifying this relationship may provide novel targets for ED treatments. For example, endorsement of feeling fat during an intake assessment may alert clinicians to assess for depressive symptoms and focusing on these depressive symptoms in treatment may improve feeling fat.
Level of Evidence:
Level I: Evidence obtained from an experimental study
Why do knees after total knee arthroplasty fail in China: a single center's experience
Authors: Zhang Liyi , li Zhichang , Kang Wulin , Gao Xuan , Lin Jianhao 
Published: June 2022

Abstract
Background
The number of revision Total Knee Arthroplasty (TKA) is rising in many countries. This study aimed to assess causes for revision TKA in China and compared reasons with previously published data.
Methods
In this study patients who had revision TKA between 2007 and 2020 were retrospectively included. Revision causes were categorized using all available information from patients’ records including preoperative diagnostics, intraoperative findings as well as the periprosthetic tissue analysis’ results. Patients were divided into early (up to 2 years) and late revision (more than 2 years). The reason for revision before 2012 and after 2012 was also compared.
Results
We assessed 337 patients who underwent 373 revision TKAs. In 345 knees this was the first revision surgery after primary TKA. Among the first revisions, half of the revisions were late revisions (50.4%). Overall, the most frequent reason for the revision was infection (38.6%), followed by aseptic loosening (28.1%) and instability (10.1%). Infection (56.1%) and aseptic loosening (49.4%) were the most frequent reason for early and late revisions.
Conclusions
In our specialized arthroplasty center infection was the most common reason for revision. Infection and aseptic loosening needed to be considered for early or late-stage revision.
Degree-corrected distribution-free model for community detection in weighted networks
Authors: Qing Huan 
Published: June 2022

Abstract
A degree-corrected distribution-free model is proposed for weighted social networks with latent structural information. The model extends the previous distribution-free models by considering variation in node degree to fit real-world weighted networks, and it also extends the classical degree-corrected stochastic block model from un-weighted network to weighted network. We design an algorithm based on the idea of spectral clustering to fit the model. Theoretical framework on consistent estimation for the algorithm is developed under the model. Theoretical results when edge weights are generated from different distributions are analyzed. We also propose a general modularity as an extension of Newman’s modularity from un-weighted network to weighted network. Using experiments with simulated and real-world networks, we show that our method significantly outperforms the uncorrected one, and the general modularity is effective.
A comparison of MRI appearance and surgical detethering rates between intrauterine and postnatal myelomeningocele closures: a single-center pilot matched cohort study
Authors: Cools Michael J. , Tang Alan R. , Pruthi Sumit , Koh Tae Ho , Braun Stephane A. , Bennett Kelly A. , Wellons John C. 
Published: June 2022

Abstract
Purpose: Intrauterine myelomeningocele repair (IUMR) and postnatal myelomeningocele repair (PNMR) differ in terms of both setting and surgical technique. A simplified technique in IUMR, in which a dural onlay is used followed by skin closure, has been adopted at our institution. The goal of this study was to compare the rates of clinical tethering in IUMR and PNMR patients, as well as to evaluate the appearance on MRI. Methods: We conducted a retrospective review of 36 patients with MMC repaired at our institution, with 2:1 PNMR to IUMR matching based on lesion level. A pediatric neuroradiologist blinded to the clinical details reviewed the patients’ lumbar spine MRIs for the distance from neural tissue to skin and the presence or absence of a syrinx. An EMR review was then done to evaluate for detethering procedures and need for CSF diversion.Results: Mean age at MRI was 4.0 years and mean age at last follow-up was 6.1 years, with no significant difference between the PNMR and IUMR groups. There was no significant difference between groups in the distance from neural tissue to skin (PNMR 13.5mm vs IUMR 17.6mm; p=0.5). There was no difference in need for detethering operations between groups (PNMR 12.5% vs IUMR 16.7%; RR 0.75; CI 0.1-5.1). Conclusions: There was no significant difference between postnatal- and intrauterine-repaired myelomeningocele on MRI or in need for detethering operations. These results imply that a more straightforward and time efficient IUMR closure technique does not lead to an increased rate of tethering when compared to the multilayered PNMR.
A cold high-pressure system over North China hinders the southward migration of Mythimna separata in autumn
Authors: Zhu Jian , Chen Xiao , Liu Jie , Jiang Yu-Ying , Chen Fa-Jun , Lu Jia-Hao , Chen Hui , Zhai Bao-Ping , Hu Gao 
Published: June 2022

Abstract
At almost any moment, the planetary boundary layer is distributed by an unimaginably huge variety and quantity of insects, but the southward migration of insects (in the Northern Hemisphere) in autumn has still been full of mystery. We collected the daily catches of Mythimna separata, a long-distance migratory moth under a wide range of light traps in 2014–2017. The results confirmed that the migration in spring and summer under the monsoon system can bring rapid population growth. However, slow southerly wind (towards the north) was prevailing over their major summer breeding area in North China (33°-40°N) due to a cold high-pressure system occupying there, thus the autumn migration of this pest was severely disturbed. Less than 8% of moths from their summer breeding area migrated into their overwintering area successfully, resulting in a sharp decline of the population abundance in autumn. As northerly wind (toward the south) is always predominated at the eastern periphery of a high-pressure system, the cold high-pressure system going westward led to more northerly wind over North China, bringing more insects migrating southward successfully. Therefore, it was further found that an outbreak year of M. separata larval was correlated with a westward high-pressure system in the previous autumn. These results indicated that the southward migration in Autumn is crucial for the population sustaining of this pest, and the position of the cold high-pressure system in September is a key environmental driver of the population scale in the next year. This study points out that the autumn migration of insects is more complex than previously recognized, and the meteorological conditions in autumn are an important driver of migratory insects’ seasonal and interannual population dynamics.