bluuebunny/crossref_metadata_2025_split huggingface dataset:
In(OTf)3 Catalyzed Regioselective Approach for Synthesis of Multi-Functionalized Benzopyranophenazine Derivatives as Latent Corrosion Inhibitors on Mild Steel in 1 M HCl
Authors: Leelakrishnan Saraswathi , Elumalai Dhanaseker , Jagadeesan Saranya , Nachimuthu Gunavathy , Jayabal Kamalraja 
Published: August 2022

AbstractA rapid and regioselective strategy have developed for synthesis of multi-functional phenazine derivatives such as 3- amino-1- (2-hydroxy phenyl) -1H- benzo[a] pyrano [2,3-c] phenazine -2- carbonitrile benzo-pyrano-phenazine(BPP), 3-amino-1-(2-hydroxy-5-methoxyphenyl)-1H-benzo[a]pyrano[2,3-c]phenazine-2-carbonitrile (MBPP)and 3-amino-1-(5-bromo-2-hydroxyphenyl)-1H-benzo[a]pyrano[2,3-c]phenazine-2-carbonitrile(BBPP)using In(OTf)3as catalyst in simple one-pot multi-component reaction. Further, the regioselectivity of the product formation was confirmed by DFT studies. In addition, the synthesized compounds were evaluated for their corrosion inhibition strength on mild steel in 1 M hydrochloric acid solution by using weight loss and electrochemical techniques in the first time. Interestingly, the inhibition efficiency was increased up to 98.64 % with an increase in the inhibitor concentration and it was decreased with increases in temperature. These results indicate that our synthesized compounds adopt the Langmuir isotherm model. Further, the polarization measurements clearly indicate that synthesized phenazine derivatives act as mixed-type inhibitors. Also, the electrochemical impedance studies (EIS) strongly revealed that these compounds inhibit corrosion by adsorption mechanism. Moreover, the efficiency of corrosion inhibitors was explained by the surface morphology of the inhibited and uninhibited specimens and was examined using scanning electron microscopy (SEM). Finally, the correlation between the inhibition performance of phenazines and their structural parameters was clearly examined by DFT calculations.
Brown Skua and South Polar Skua (Aves: Stercorariidae) A Hybridization Case or Same Species?
Authors: Mota Ana Carolina Marinho , Costa Erli Schneider , Torres João Paulo Machado , Araujo Jansen , Tormena Larissa Castro , Dantas Gisele Pires de Mendonça 
Published: August 2022

Abstract
Brown Skua (Stercorarius antarctica-lonnbergi) and South Polar Skua (Stercorarius maccormicki) aoccur in the Antarctic Peninsula and are sympatric in distribution over about 500km. In this region hybridization between a male of South Polar Skua and a female Brown Skua producing a viable and fertile offspring has been reported. The present study aims to review the evolutionary history of South Polar Skua and Brown Skua to better understand the hybridization process between these species. To assess the evolutionary history between these species, 67 DNA samples were sequenced for AK1 locus, 70 samples for RAG1 locus and 96 samples for Cytb locus, sampling in King George and Elephant Island. Cytb and RAG1 loci showed greater genetic diversity in samples from hybrid birds than those of non-hybrid individuals and may reflect the outcome of the heterosis. Overall Brown Skua had higher genetic diversity than South Polar Skua. In addition, South Polar Skua showed probable populational expansion signals, in contrast to Brown Skua that showed population stability through time. However, our phylogenetic analysis did not corroborate the reciprocal monophyly between these species. Thus, South Polar Skua and Brown Skua show incomplete lineage sorting, indicating these species are a single taxonomic group.
Mainstreaming River sensitive urban planning approaches in Riverine cities-A case of Madurai city, Tamilnadu , India
Authors: P Jai Shankar , D Karthigeyan 
Published: August 2022

Abstract
Rivers and cities have a symbiotic connection in many ways, with interconnected surrounding ecosystems such as water bodies, channels, and natural drainage. However, rapidly changing climatic conditions, rising urbanisation, and out-of-date infrastructure exacerbate water difficulties by creating floods, water scarcity, and rehabilitation expenses on a scale that will surpass cities' capacity. The city-river connection is a strong, multi-generational link that must be considered when dealing with urban planning, infrastructure development, or even administration in the area, the Indian urban river management between city-river in riverine cities are in weaker relationship. Madurai city which is in banks of river Vaigai, there are concerns regarding Pollution in the rivers, drying up of river stretches, encroachment into floodplains, loss of river related biodiversity, and several others. Invariable development activities in the urban area to the river are the biggest cause for these issues and challenges. The Madurai's Master Plan dissatisfy to meet increasing urban development difficulties and challenges. The forthcoming Master Plan must plan for a river sensitive urban growth. This thesis research aims to include river sensitive planning within the city’s administrative boundaries, that views the river as a resource and guarantees that the city's development activities do not harm the river's health through environmentally inclusive development on both sides of the river, strengthening citizen-water connect, by enhancing quality of life, expanding opportunity while preserving the city’s character into a more resilient.
Association of 410L, 1016I and 1534C kdr mutations with pyrethroid resistance in Aedes aegypti from Ouagadougou, Burkina Faso, and development of a one-step multiplex PCR method for the simultaneous detection of 1534C and 1016I kdr mutations
Authors: Sombié Aboubacar , Ouédraogo Mathias W. , Oté Manabu , Saiki Erisha , Sakurai Tatsuya , Yaméogo Félix , Sanon Antoine , McCall Philip , Kanuka Hirotaka , Weetman David , Badolo Athanase 
Published: August 2022

Abstract
Background: Since 2000, Burkina Faso has experienced regular dengue cases and outbreaks making dengue a health concern for the country. Previous studies in Burkina Faso reported the resistance of Aedes aegypti to pyrethroid insecticides associated with F1534C and V1016I kdr mutations. The current study reports high resistance of Ae. aegypti populations to pyrethroid insecticides supported by 410L/1016I/1534C kdr haplotypes; and a new multiplex PCR-based diagnostic of 1534C and 1016I kdr mutations is proposed. Methods: Larvae of Ae. aegypti were collected from three health districts of Ouagadougou in 2018. The resistance status of Ae. aegypti to pyrethroid insecticides was tested using CDC-bottle bioassays, and to malathion using WHO tube tests. Bioassay results were interpreted according to used protocols. Results: Females from each health district were strongly resistant to permethrin and deltamethrin (<20% mortality) but were fully susceptible to 5% malathion. The F1534C and V1016I kdr mutations were successfully detected using a newly-developed multiplex PCR, which was validated by comparison with fluorescent probe-based TaqMan assays for each mutation. The V410L kdr mutation was detected using an allele-specific-PCR, which was confirmed by TaqMan assays, and owing to novelty in local Ae. aegypti populations, also direct DNA sequencing. The 1534C kdr allele was near fixation, while V1016I and V410L kdr alleles were strongly correlated with allelic frequencies range from 0.5 to 0.7 across the three-health districts. The 1534C/1016I/410L haplotype was correlated with permethrin resistance (χ21=33.7; p<0.001) but not with deltamethrin resistance (χ21=0.03; p=0.86), however, the test power was limited by a low frequency of dead individuals. Conclusions: The trio of kdr mutations (F1534C, V1016I and V410L) may explain the high resistance to pyrethroids, however lack of substantial resistance to malathion suggests that this remains a viable option for dengue vectors control in Ouagadougou.
PV Fed EV Charging System Based on Re-Lift Luo Converter and DAB Converter
Authors: Kumar MuthuRam , Karuvelam Subha Karuvelam Subha 
Published: August 2022

Abstract
The insufficiency and soaring rate of fossil fuels, as well as growing concerns about global warming, have pushed Electric Vehicles (EV) to become a significant aspect of the future transportation system. The growth in adoption of EVs results in the need for broadly spread charging stations, hence a Photovoltaic (PV) based EV charging system is adopted, since the generation of power from PV is possible everywhere. An EV charging system with two converters is constructed in this research work, one of which is a re-lift Luo converter and the other is a Dual Active Bridge (DAB) converter. A re-lift Luo converter is adopted for conversion of the low PV voltage output to an enhanced voltage of higher level. The DAB converter is effective in providing the required galvanic isolation and allowing bidirectional power flow. The PV system’s output voltage fluctuates with changing weather conditions and solar irradiation. Hence, the operation of the re-lift Luo converter is controlled by using the Fuzzy Logic Controller (FLC), which is highly capable of addressing the uncertainties associated with PV output. The operation of the DAB converter is controlled by implementing Phase Shift (PS) control technique. MATLAB simulation is done to validate the proposed system's performance.
Professional resilience strategies utilized by occupational therapists to combat occupational stressors in health and social care settings
Authors: Ashby Samantha , Wales Kylie , Watkins Katrina 
Published: August 2022

AbstractPurposeThe adoption of professional resilience strategies can foster and maintain career longevity in health and social care. This study investigates the professional resilience strategies used by occupational therapists to mitigate occupational stressors in workplaces and enhance career longevity.MethodCross-sectional survey. Participants were occupational therapy practitioners with two or more years work experience.ResultsThe survey was completed by 494 occupational therapists from 29 countries. The most used strategies were: Maintaining a belief in the value of occupational therapy, taking time for reflection on positive outcomes, using personal time management strategies, and engagement in informal and formal professional support networks.ConclusionsWhile health and social care workplaces inherently include occupational stressors, implementation of professional resilience strategies at service-level practitioner-level strategies and education-level assist in mitigating stressors and strengthen professional resilience. The identification of the strategies experienced occupational therapists use to counter occupational stressors and maintain professional resilience may enable practitioners and organizations to adopt effective strategies. For employers, cultivation of work-based professional resilience strategies which mitigate occupational stressors could improve the retention of occupational therapists in the workforce.
Environmental adaptability of the genus Carex-A case study of Carex heterostachya and Carex breviculmis in northwest China
Authors: Wang Xiaoqi , Feng Yuhan , Feng Xuewei , Liu Wanting , Hua Jinguo , Xie Fei , Ji Wenli 
Published: August 2022

Abstract
Carex heterostachya (CH) and Carex breviculmis (CB) are easy to develop lawns in a short period and exhibit high ornamental value in northwest China with high summer temperatures, uneven rainfall, and poor soil. Several questions are raised, including what type of plant functional traits has they formed for long-term survival and adaptation to this environment, which plant is more adaptable, as well as which leaf functional traits are critical to photosynthetic characteristics. After exploring the leaf functional traits of the two plants by gas exchange technology and field emission electron scanning technology, the following conclusions are drawn: (a) CB is a slow investment-return plant, which exhibits strong environmental adaptability and plasticity, and is resistant to barrenness, drought and shade. CH is a kind of quick investment-return plant, with high photosynthetic efficiency, well-developed transport tissue, and relatively shade-tolerant. The soil with low water content and poorer soil is suitable for CB cultivation, and CH is suitable for cultivation in the environment with sufficient light and rich nutrients. At the same time, both CB and CH can be used to enrich the diversity of understory landscape. (b) Carex have strong environmental adaptability, large variation in leaf structure traits, as well as strong plasticity. Leaf anatomical characters are stable, whereas there are differences in the interspecific variability and plasticity. (c) Specific leaf area (SLA) can serve as the main factor affecting the photosynthetic availability of Carex, the thickness of the stratum corneum(CUT), the thickness of the upper(UET) are secondary factors. These finding can provide a theoretical basis for the cultivation and application of Carex and the expansion of turfgrass germplasm resources.
IL33-regulated NPM1 promotes fibroblast-to-myofibroblast transition via ERK/AP-1 signaling in silica-induced pulmonary fibrosis
Authors: Wang Yue , Cheng Demin , Li Ziwei , Sun Wenqing , Zhou Siyun , Peng Lan , Xiong Haojie , Jia Xinying , Li Wei , Han Lei , Liu Yi , Ni Chunhui 
Published: August 2022

Abstract
Background
Silicosis is a global occupational lung disease caused by the accumulation of silica dust. There is a lack of effective clinical drugs, and the pathogenic mechanisms remain obscure. Interleukin 33 (IL33), a pleiotropic cytokine, could promote wound healing and tissue repair via the receptor ST2. However, the mechanisms by which IL33 involves in silicosis progression need further exploration.
Results
Here, we demonstrated that the IL33 levels in the lung sections were significantly overexpressed after bleomycin (BLM) and silica treatment. ChIP assay, knockdown and reverse experiments were performed in lung fibroblasts to prove gene interaction following exogenous IL33 treatment or co-cultured with silica-treated lung epithelial cells. Mechanistically, we illustrated that silica-stimulated lung epithelial cells secreted IL33 and further promoted the activation, proliferation, and migration of pulmonary fibroblasts by activating the ERK/AP-1/NPM1 signaling pathway in vitro. Also, Treatment with NPM1 siRNA-loaded liposomes markedly protected mice from silica-induced pulmonary fibrosis in vivo.
Conclusions
In this study, we identified that NPM1 could involve in the progression of silicosis, which was regulated by IL33/ERK/AP-1 signaling. And treatment methods targeting this pathway may provide new anti-fibrotic clues in pulmonary fibrosis.
High transcriptional activity and clinical correlations in eosinophils of patients with late-onset asthma
Authors: Lin Ting-Yu , Lo Chun-Yu , Chang Po-Jui , Lo Yu-Lun , Lee Chung-Shu , Chang Chih-Hao , Yu Chih-Teng , Yao Jonathan Huai , Lin Shu-Min 
Published: August 2022

Abstract
Background
The immunological features of eosinophils in early-onset asthma (EOA) differs from that in late-onset asthma (LOA). Clinical trials of anti-interleukin-5 (IL-5) treatment for severe eosinophilic asthma showed a better response for LOA patients than EOA patients. We wonder if the transcriptional activity of activated eosinophils was different in EOA and LOA.
Methods
Eosinophils obtained from well controlled EOA and LOA patients and normal subjects were compared in terms of the mRNA expression of activation-related genes (integrins α4 and β2, CCR3, CCR5, and IL-5Rα, and IL-17RA) and specific markers (IL-4Rα, prostaglandin D2 receptor 2, high-affinity IgE receptor, TGF-β1, aryl hydrocarbon receptor, and endosomal TLR-3, 7, and 9) in eosinophils activated by IL-5 or IL-17. The correlation between mRNA expression and clinical features and lung function were further analyzed.
Results
The transcriptional expression of most genes was higher in activated eosinophils from LOA patients than in those from EOA patients and normal subjects. After IL-17 stimulation, the expression of certain genes was higher in atopic EOA patients than in non-atopic EOA patients. Similar observation was noted in obese EOA patients. After IL-5 stimulation, the transcriptional expression of most genes in eosinophils from LOA patients was negatively correlated with indicators of lung function. These correlations were less pronounced in EOA patients: After IL-17 stimulation, some genes in EOA patients were negatively correlated with post-bronchodilator changes in lung function. There was no significant correlation between mRNA expression and treatment control levels among LOA or EOA patients
Conclusion
This study describes differences in the transcriptional active patterns of eosinophils and their correlation to atopy and obese by age of onset. High transcriptional activity in activated eosinophils and a negative correlation to lung function indicate the importance of eosinophils in the pathogenesis of LOA.
Introducing Extended Consultations for Patients with Severe Mental Illness in General Practice. Results from the SOFIA Feasibility Study
Authors: Jønsson ABR , Martiny FHJ , Søndergaard MK , Brodersen JB , Due TD , Nielsen MH , Bakkedal C , Bardram JE , Bissenbakker K , Christensen I , Doherty K , Kjellberg P , Mercer SW , Reventlow S , Rozing MP , Møller A 
Published: August 2022

Abstract
Background
The SOFIA intervention aims to improve life expectancy and quality of life for patients with severe mental illness (SMI). The complex intervention was co-designed with relevant stakeholders and consists of an extended consultation in general practice, focusing on a patient-centred and structured care approach. We tested its feasibility and assessed the clinical content of extended consultations as preparation for a larger randomized pilot study.
Methods
The study was a one-armed feasibility study. We planned that seven general practices in northern Denmark would introduce extended consultations with their patients with SMI for six months. Patients with SMI were identified using practice medical records and screened for eligibility by the patients’ general practitioner (GP). Data were collected using case report forms filled out by practice personnel and via qualitative methods, including observations of consultations, individual semi-structured interviews, a focus group with GPs, and informal conversations with patients and general practice staff.
Results
Five general practices employing seven GPs participated in the study, which was terminated 3 ½ month ahead of schedule due to the COVID-19 pandemic. General practices contacted 57 patients with SMI. In total, 38 patients (67%) attended an extended consultation, which led to a change in patients’ somatic health care plan in 82% of consultations. The conduct of the extended consultations varied between GPs and diverged from the SOFIA protocol. Nonetheless, GPs found that the extended consultations were feasible and, in most cases, perceived as beneficial for the patient group. Most patients also perceived an extended consultation as beneficial.
Discussion
Our findings suggest that extended consultations for patients with SMI in general practice are feasible and perceived as beneficial by GPs and patients. Larger studies with a longer follow-up period could help to assess the long-term effects and the best implementation strategies for introducing extended consultations for patients with SMI in general practice.
Conclusion
Introducing extended consultations for patients with SMI in the Danish general practice setting was feasible and acceptable to patients and GPs. Extended consultations are well-suited for eliciting patients’ values and preferences and likely lead to changes in most patients’ somatic health care plans.
Association of Social deprivation with cognitive abilities in older adults in India – Evidence from LASI
Authors: Barman Poulami , Pandey Mohit , Bramhankar Mahadev , Tyagi Rishabh , Rai Balram 
Published: August 2022

AbstractBackground Existing evidence indicates that the link between socioeconomic status and mental health is complex and overlapping. Although cognitive functioning declines with age and is directly linked to biological brain changes as people age, socioeconomic factors play an essential role in the level and change of cognitive functioning and onset of depression in older adults. This study attempts to assess the association between social deprivation, cognitive status, and depression among older persons in India. Data and Methods The LASI Wave 1, collected in India between 2017 and 2018, was used for this study. Social deprivation Index (SDI) was constructed. Education, wealth quintile, working status, living arrangements etc. were SDI indicators. Multivariate logistic regressions were used to establish the association between outcome and explanatory variables. Results The findings reveal that 31% of people with higher social deprivation have poor cognitive health compared to only 8% of people with lower social deprivation. Further, 60.5% of people with higher social deprivation have depressive symptoms compared to 25.8% of people with lower social deprivation. The prevalence of poor cognitive health (18.5%) and depressive symptoms (32.1%) are highest among older adults with no schooling, and further the good cognitive health (0.3%) in older adults with ten or more years of education. The exploratory analysis indicated that cognitive health and depressive symptoms were significantly associated with age, place of residence, marital status, caste/tribe, and religion. Conclusion The findings suggest that older adults (75 and above) with depressive and cognitive dysfunctioning were the largest in the case of highly socially deprived. In other age groups, highly socially deprived people are more vulnerable to poor cognitive health and depressive symptoms. The findings from the study inform the policymakers and planners to devise policies considering equitable healthcare needs to improve mental health among older adults, which is generally ignored in India.
Caspase-8 Contributes to Immuno-Hot Microenvironment by Promoting Phagocytosis via an Ecto-Calreticulin-dependent Mechanism
Authors: Gong Zhihua , Jia Qingzhu , Xu Shouxia , Jin Zheng , Chu Han , Wan Yisong Y. , Zhu Bo , Zhou Yi 
Published: August 2022

Abstract
Background
Caspase-8 play as an initiator caspase of cell apoptosis signaling. However, the role of caspase-8 in tunning tumor immune microenvironment remains controversial due to a complicated crosstalk between immuno-tolerogenic apoptotic cell death and immunogenic cell death (ICD) cascades.
Methods
TCGA and publicly accessible immune checkpoint blockade (ICB)-treated cohort were introduced to investigate the clinical relevance of caspase-8. Tumor-bearing mouse model was used to characterize the change of tumor microenvironment and explore efficacy to ICB treatment in caspase-8 knockout condition.
Results
We showed that the expression level of Casp8 was associated with an immuno-hot microenvironment across various solid tumor types by exploring TCGA dataset. Casp8 deficiency led to decreased CD8+ T cell infiltration and resistance to αPD-L1 therapy in mouse model. Mechanistically, Casp8 deficiency or pharmacological disruption resulted in impaired ecto-calreticulin (ecto-CRT) transition on tumor cells, which in turn hampered antigen presentation in draining lymph node. Furthermore, radiotherapy restore the sensitivity to αPD-L1 treatment via elevated surface expression of CRT.
Conclusions
Our data revealed a causative role of Casp8 in modulating immunogenicity of tumor cells and responsiveness to immune checkpoint blockade immunotherapies and proposed that radiotherapy as a salvage approach to overcome Casp8 deficiency-mediated ICB resistance.