bluuebunny/crossref_metadata_2025_split huggingface dataset:
E2F1 and MYC activated SNHG15 promotes gastric cancer progression via interacting with miR-24-3p to regulate cell cycle and ferroptosis
Authors: Duan Yantao , Li Kun , Dou Yi , Dong Yang , Huang Binhao , Guo Jing , Kong Pengfei , Liu Yifan , Liu Bin , Long Manmei , Chen Xu , Kang Wei , Wei Gonghong , Cai Qiliang , Xu Dazhi 
Published: June 2022

Abstract
Background: The regulatory loop between long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) plays a dynamic role in transcriptional and translational regulation, and is involved in carcinogenesis. However, the regulatory circuitry between lncRNAs and miRNAs in gastric cancer (GC) remains elusive.Methods: The novel SNHG15 was identifed by analyzing RNA-sequencing (RNA-seq) data of GC tissues from our cohort and TCGA dataset, and further validated by qRT-PCR in GC cells and tissues. Gain- and loss-of-function assays were performed to examine the role of SNHG15 on GC both in vitro and in vivo. The regulatory mechanisms of SNHG15 were investigated by bioinformatics, fuorescence in situ hybridization (FISH), luciferase reporter assay, and chromatin immunoprecipitation (ChIP) assay. Meanwhile, the oncogenic activity of SNHG15 was explored in both GC cells and animal xenograft studies.Results: SNHG15 is highly expressed in GC. The enhanced SNHG15 exists in GC and positively correlates with malignant stage and poor prognosis in GC patients. Gain- and loss-of-function studies showed that SNHG15 was required for affecting cell growth, migration and invasion both in vitro and in vivo. Mechanistically, the oncogenic transcription factors E2F1 and MYC could bind to the SNHG15 promoter and enhance its expression. Meanwhile, SNHG15 increased E2F1, MYC and CDC25A mRNA expression by sponging miR-24-3p. In addition, SNHG15 could also inhibit ferroptosis through a miR-24-3p-mediated regulation of MDM2/p53/SLC7A11 signalling axis.Conclusions: Our results support a novel model in which the E2F1, MYC/SNHG15/miR-24-3p crosstalk served as the critical effectors in GC tumorigenesis and progression, providing a new therapeutic direction in the treatment of GC.
Machine learning-based evidence and attribution mapping of 100,000 climate impact studies
Authors: Callaghan Max , Schleussner Carl-Friedrich , Nath Shruti , Lejeune Quentin , Knutson Thomas R. , Reichstein Markus , Hansen Gerrit , Theokritoff Emily , Andrijevic Marina , Brecha Robert J. , Hegarty Michael , Jones Chelsea , Lee Kaylin , Lucas Agathe , Maanen Nicole van , Menke Inga , Pfleiderer Peter , Yesil Burcu , Minx Jan C. 
Published: June 2022

Abstract
An ever-growing body of evidence suggests that climate change is already impacting human and natural systems around the world. Global environmental assessments assessing this evidence, for example by the Intergovernmental Panel on Climate Change (IPCC)1, face increasing challenges to appraise an exponentially growing literature2 and diverse approaches to climate change attribution. Here we use the language representation model BERT to identify and classify studies on observed climate impacts, producing a machine-learning-assisted evidence map which provides the most comprehensive picture of the literature to date. We identify 100,724 (62,950 − 162,838) publications covering a broad range of impacts in human and natural systems across all continents. By combining our spatially resolved database with human-attributable changes in temperature and precipitation on the grid cell level, we infer that attributable climate change impacts may be occurring in regions encompassing 85% (80%) of the world's population (land area). Our results also reveal a substantial 'attribution gap' as robust evidence for attributable impacts is twice as prevalent in high income compared to low income countries. While substantial gaps remain on confidently establishing attributable climate impacts at the regional and sectoral level, our unique database illustrates the broad extent to which anthropogenic climate change may already be impacting natural systems and societies across the globe.
Development of Wavelet Based Image Compression Approach Using Modified SPIHT Algorithm
Authors: Shelke Sandeep Kashinath , Sinha Sanjeet k. , Patel Govind Singh 
Published: June 2022

Abstract
In case of images & videos, the encoding philosophy is substantially different as compared to that of speech. The very basic difference between image & speech is that, the speech signals are one dimensional, whereas the images are two dimensional in nature. Modern day images can have the resolution in the range of ‘1024 x 1024’, this means there will 1 Mega Pixels & for color images, 1 pixel is represented by 24 bits (8 bits for each pixel component of red, green & blue), that means there are 24 Megabits in a single still image. In videos such still images are changing at 30 frames per second, so the basic bit rate going to be 30 times of 24 Megabits, this leads to the explosion in information. This demands compression of images at significant extent. In this work, image compression is achieved by using transformation based on modified lifting wavelet structure followed by quantization based on modified set partition in hierarchical tree (SPIHT) algorithm. This modification in SPIHT algorithm helps to reduce the bit stream length of compressed signal to significant extent as compared to conventional SPIHT algorithm. The proposed architecture is developed with Verilog language and simulated with modelsim simulator and synthesized with XST(VHDL/Verilog) tool of Xilinx software under Virtex6-XC6VLX240TD environment. The comparative analysis of proposed system with existing system shows that, there is significant improvement in compression ratio & PSNR.
Measuring H2O concentrations in olivine by secondary ion mass spectrometry: Challenges and paths forward
Authors: Towbin W. Henry , Plank Terry , Klein Emily , Hauri Erik 
Published: June 2022

Abstract
Trace concentrations of H2O in olivine strongly affect diverse mantle and magmatic processes. H2O in olivine has been difficult to accurately quantify due to challenges in sample preparation and measurement, as well as significant uncertainties in standard calibrations. Here we directly compare secondary-ion mass spectrometry (SIMS) measurements of the olivine standards of Bell et al. (2003, hereafter Bell03) and Withers et al. (2012, hereafter Withers12) upon which most SIMS and Fourier transform infrared (FTIR) spectroscopy analyses are based. In the same SIMS session, we find that the olivine standards from the two studies are offset by ~50%, forming lines of different slope when comparing SIMS measurements to the independent nuclear reaction analysis (NRA) in Bell03 and elastic recoil detection analysis (ERDA) in Withers12. This offset is similar to the ~40% offset that exists in the FTIR absorption coefficients determined by those two studies, and points to the NRAERDA data as the cause for the offset more than different IR absorption characteristics of the different olivines. We find that the Withers12 olivine standards form the most precise calibration line, and that the measured Bell03 olivine standards have issues of reproducibility and accuracy due to the presence of hydrous inclusions (as documented previously by Mosenfelder et al. 2011). Owing to the limited availability of the Withers12 olivine standards, however, we recommend using orthopyroxene standards (Kumamoto et al. 2017) to calibrate H2O in olivine by SIMS due to similar calibration slopes. We revise the reference values of current orthopyroxene standards to account for uncertainties in the Bell et al. (1995) manometry data. With these revised values, the orthopyroxene calibration line is within 12% of the Withers12 olivine line, which is within the long-term uncertainty of the SIMS olivine measurements. We apply our SIMS calibration protocol to revise estimates of the partition coefficients for H2O between olivine and melt, resulting in a value of 0.0009 ± 0.0003 at pressures ~0.2–2 GPa. This brings into closer agreement between the partition coefficients determined from experimental studies and those based on natural studies of olivine-hosted melt inclusions.
Visiones y debates de la cooperación sur-sur y triangular. Actores gubernamentales, sociales y privados
Authors: Fagaburu Debora 
Published: June 2022

El objetivo de este texto es reseñar Visiones y debates de la cooperación sur-sur y triangular: actores gubernamentales, sociales y privados, un libro de carácter académico editado y coordinado por la Dra. Tahina Ojeda Medina y publicado en julio de 2020 por el Instituto Universitario de Desarrollo y Cooperación de la Universidad Complutense de Madrid y la Editorial Los Libros de la Catarata. En el marco de las teorías de las Relaciones Internacionales, la obra compila los trabajos de un grupo de autores dedicados a la investigación y a la asistencia técnica sobre el campo de estudio de la cooperación sur-sur y de la cooperación triangular latinoamericana e iberoamericana. En el contexto de la Agenda 2030 y los Objetivos de Desarrollo Sostenible, los seis capítulos manifiestan diversas estrategias teóricas y prácticas para decodificar las motivaciones, intereses y objetivos de los diferentes actores inmersos en los procesos de estas modalidades de cooperación. Con una perspectiva crítica, los trabajos de la obra resaltan los desafíos que enfrentan los países del Sur para adaptarse y apropiarse de la Agenda 2030, pero también la existencia de capacidades instaladas y experiencias que brindan un piso de oportunidades para mejorar la eficiencia y la eficacia de la cooperación sur-sur y de la cooperación triangular de mano de actores clave a nivel intergubernamental. Ello conduce a destacar el vínculo entre política exterior, la política de cooperación y su influencia en las actuaciones de los Estados y los diversos actores intergubernamentales en el plano doméstico, así como el relacionamiento entre aquellos y actores del sector privado y organizaciones de la sociedad civil. En conclusión, el libro combina la teoría y la práctica de la cooperación sur-sur y de la cooperación triangular en América Latina e Iberoamérica resaltando, por un lado, la multiplicidad de actores que se sumergen en su implementación desarrollando un juego de roles de acuerdo a intereses que pueden ser conflictivos pero complementarios, y por otro lado, los aportes de estas ejecuciones al logro de la Agenda 2030 y los Objetivos de Desarrollo Sostenible, pues pueden ser poco visibles pero contundentes. Por todo ello, la lectura de Visiones y debates de la cooperación sur-sur y triangular: actores gubernamentales, sociales y privados es altamente recomendable, no solo para los miembros de la academia, sino también para los policy makers y los diversos actores que la practican, a los fines de comprender de forma más integral su accionar en los procesos de estas modalidades de cooperación e identificar respuestas a los actuales desafíos del sistema internacional.
Palabras clave: Cooperación sur-sur; Cooperación triangular; Actores; Agenda 2030; Objetivos de Desarrollo Sostenible.
Principios orientadores para la investigación y judicialización de la trata de personas cuando su comisión involucra actores indígenas
Authors: Diaz Echeverri Maria Ximena 
Published: June 2022

La trata de personas es un delito transnacional que reviste cada vez mayor relevancia en los ámbitos nacional e internacional. Lograr su total erradicación se ha convertido incluso en una de las metas de los objetivos de sostenibilidad –concretamente la meta 8.7–, pero para lograr una real lucha contra este delito es necesario que toda la sociedad esté de acuerdo en su persecución y castigo. De lo contrario, las redes que protegen su comisión se fortalecen permeando aquellos escalones de la sociedad que no están dispuestos a reprimir este delito y que por el contrario buscan “normalizar” su comisión, incentivando estereotipos bajo los cuales ciertas personas, especialmente mujeres, niños y población vulnerable pueden ser sometidos a los designios de otra persona. Una de las poblaciones más afectadas por esta conducta es la población indígena, de donde no sólo se extraen personas para ser tratadas sino que además ocurren las mismas conductas al interior de ciertas comunidades y bajo el “amparo” de ciertas tradiciones o cosmovisiones ancestrales. A pesar de la independencia reconocida a la jurisdicción indígena, la vulneración de la dignidad humana exige canales de comunicación con la jurisdicción ordinaria orientados a impedir que el delito se siga propagando.
En este artículo se recogen principios orientadores que permiten cruzar puentes entre la jurisdicción especial indígena y la jurisdicción ordinaria para que sea posible luchar contra el delito de trata de personas con independencia de la jurisdicción que asuma el conocimiento de cada caso. Se espera de esta manera contribuir a que ningún caso de trata, incluidos aquellos en los que se involucran actores indígenas, quede marginado al silencio de la justicia, sino que existan y puedan consultarse las herramientas que faciliten el diálogo interjurisdiccional y el encuentro intercultural para rescatar siempre la dignidad humana e impedir que esta siga siendo desdibujada en el seno de cualquier sociedad.
Palabras clave: jurisdicción indígena, delito, trata de personas, comunidades, indígenas.
En este artículo se recogen ciertos principios orientadores que permiten cruzar puentes entre la jurisdicción especial indígena y la jurisdicción ordinaria para que sea posible luchar contra el delito de trata de personas con independencia de la jurisdicción que asuma el conocimiento de cada caso. Se espera de esta manera contribuir a que ningún caso de trata, incluidos aquellos en los que se involucran actores indígenas quede marginado al silencio de la justicia, sino que existan y puedan consultarse las herramientas que faciliten el diálogo interjurisdiccional y el encuentro intercultural para rescatar siempre la dignidad humana e impedir que esta siga siendo desdibujada en el seno de cualquier sociedad.
Propidium monoazide-quantitative PCR to detect viable Legionella spp. in the supply process of tap water
Authors: Lee Eun-Sook , Han Ji-Sun 
Published: June 2022

Abstract
Legionella are common in the aquatic environment and are responsible for legionellosis including severe pneumonia and Pontiac fever. The culture method has some limitations in quickly detecting viable Legionella. Therefore, we optimized real-time PCR (qPCR) combined with propidium monoazide (PMA) to quantify viable Legionella in the supply process of tap water, considering factors such as PMA concentration, length of the target gene, and turbidity of water samples. Among 30, 50, 100, and 200 μM PMA concentration, 100 μM PMA had the greatest difference in copy number between PMA-treated live and dead cells while minimizing the cytotoxic effect on live cells. Among the various sizes of the target gene (108, 386, 456, and 654 bp), the primer in 386 bp size effectively excluded dead cells without loss of qPCR efficiency. As a result of applying the PMA-qPCR method to samples including river, purified water, and tap water, live and dead cells could be distinguished for samples with turbidity of less than 10 NTU. The optimized PMA-qPCR can be a useful method of rapidly detecting viable Legionella spp. in the process of supplying tap water, and contributing to tap water that is safe from pathogens.
A Clinical Decision Support System for Assessing the Risk of Cervical Cancer: Development and Evaluation Study
Authors: Chekin Nasrin , Ayatollahi Haleh , Karimi Zarchi Mojgan 
Published: June 2022

Background
Cervical cancer has been recognized as a preventable type of cancer. As the assessment of all the risk factors of a disease is challenging for physicians, information technology and risk assessment models have been used to estimate the degree of risk.

Objective
The aim of this study was to develop a clinical decision support system to assess the risk of cervical cancer.

Methods
This study was conducted in 2 phases in 2021. In the first phase of the study, 20 gynecologists completed a questionnaire to determine the essential parameters for assessing the risk of cervical cancer, and the data were analyzed using descriptive statistics. In the second phase of the study, the prototype of the clinical decision support system was developed and evaluated.

Results
The findings revealed that the most important parameters for assessing the risk of cervical cancer consisted of general and specific parameters. In total, the 8 parameters that had the greatest impact on the risk of cervical cancer were selected. After developing the clinical decision support system, it was evaluated and the mean values of sensitivity, specificity, and accuracy were 85.81%, 93.82%, and 91.39%, respectively.

Conclusions
The clinical decision support system developed in this study can facilitate the process of identifying people who are at risk of developing cervical cancer. In addition, it can help to increase the quality of health care and reduce the costs associated with the treatment of cervical cancer.
Studying the Effect of Long COVID-19 Infection on Sleep Quality Using Wearable Health Devices: Observational Study
Authors: Mekhael Mario , Lim Chan Ho , El Hajjar Abdel Hadi , Noujaim Charbel , Pottle Christopher , Makan Noor , Dagher Lilas , Zhang Yichi , Chouman Nour , Li Dan L , Ayoub Tarek , Marrouche Nassir 
Published: June 2022

Background
Patients with COVID-19 have increased sleep disturbances and decreased sleep quality during and after the infection. The current published literature focuses mainly on qualitative analyses based on surveys and subjective measurements rather than quantitative data.

Objective
In this paper, we assessed the long-term effects of COVID-19 through sleep patterns from continuous signals collected via wearable wristbands.

Methods
Patients with a history of COVID-19 were compared to a control arm of individuals who never had COVID-19. Baseline demographics were collected for each subject. Linear correlations among the mean duration of each sleep phase and the mean daily biometrics were performed. The average duration for each subject’s total sleep time and sleep phases per night was calculated and compared between the 2 groups.

Results
This study includes 122 patients with COVID-19 and 588 controls (N=710). Total sleep time was positively correlated with respiratory rate (RR) and oxygen saturation (SpO2). Increased awake sleep phase was correlated with increased heart rate, decreased RR, heart rate variability (HRV), and SpO2. Increased light sleep time was correlated with increased RR and SpO2 in the group with COVID-19. Deep sleep duration was correlated with decreased heart rate as well as increased RR and SpO2. When comparing different sleep phases, patients with long COVID-19 had decreased light sleep (244, SD 67 vs 258, SD 67; P=.003) and decreased deep sleep time (123, SD 66 vs 128, SD 58; P=.02).

Conclusions
Regardless of the demographic background and symptom levels, patients with a history of COVID-19 infection demonstrated altered sleep architecture when compared to matched controls. The sleep of patients with COVID-19 was characterized by decreased total sleep and deep sleep.
50 Años de Formación Profesional en Enfermería con Excelencia Académica y Proyección Social
Authors: Bautista-Rodríguez Luz Marina 
Published: June 2022

El Programa de Enfermería de la Universidad Francisco de Paula Santander (UFPS) cumple 50 años de creación; celebrar un nuevo aniversario es motivo de orgullo, reflexión y reconocimiento de la senda recorrida, que ha permitido el posicionamiento del programa y de los graduados a nivel regional, nacional e internacional.
Los logros y avances del programa inician desde que la Universidad Francisco de Paula Santander en rectoría del Dr. José Luis Acero Jordán (QEPD), mediante análisis previos y estudio de los diferentes sectores de salud en el Norte de Santander, creyó conveniente orientar mediante el Plan de Desarrollo 1969 – 1971 la creación de una carrera en el área de la salud; considerando Enfermería como una necesidad apremiante, ante el contexto de crecimiento de las Instituciones Prestadoras del Servicio de Salud, como la antigua Clínica del Seguro Social, Clínica San Antonio, Hospital Amelia, Hospital San Juan de Dios y los Puestos de salud existentes, que atendían a la población del departamento Norte de Santander.
Comparative characteristics of morphofunctional state of organs in black-back herring (Alosa kessleri kessleri) caught in different years
Authors: Grushko Maria Pavlovna , Fedorova Nadezhda Nikolaevna 
Published: June 2022

The purpose of the research was to consider pathological characteristics of tissues and organs of black-back herring (Alosa kessleri kessleri) in different years. Results of the comparative analysis of pathohistological changes
in the organs were taken into account, since this method allows revealing pathological changes in herring organs and tissues, and comparative analysis of histomorphological parameters of black back herring in different years allowed determining changes in the degree and level of a pathological process in the course of time. There were studied the matured species of black back herring Alosa kessleri kessleri (Grimm) caught for analysis during the spawning run in the Volga River in 2014 and 2021. Six hundred of histological sections of organs (liver, kidneys, spleen, intestines, and gills) in 37 species were prepared and analyzed. The species selected for the study were 2 and 3 years old. The material was processed by the classical histological methods. Pathomorphological study of black back herring’s organs in different years showed that the studied fish species experienced high stress. There has been found a wide range of pathologies which could be caused by a chronic ingestion of pollutants from the environment. It has been stated that the organs through which pollutants enter were most affected (gills, liver, kidneys). The main manifestations
of a pathological process were microcirculatory disorders, edema, necrosis, inflammation, connective tissue over-growth, epithelial hyperplasia. All the detected pathological changes in fish organs arose due to the modern environment, which is explained by the disturbances resulting from significant changes in aquatic and terrestrial ecosystems
IMPLEMENTASI PEMANENAN AIR HUJAN (RAINWATER HARVESTING) PADA MASA PANDEMI COVID-19 DI KOTA SERANG
Authors: Wigati Restu , Mina Enden , Kusuma Rama Indera , Kuncoro Hendrian Budi Bagus , Fathonah Woelandari , Ruyani Nyi Raden 
Published: June 2022

Ketersediaan air bersih berkelanjutan adalah bagian upaya mewujudkan kesejahteraan umum dan mencerdaskan kehidupan bangsa. Pandemi menyadarkan kita perlunya aspek perilaku hidup bersih dan sehat untuk meminimalisir potensi penyebarluasan Covid-19. Berdasarkan data Survei Indonesia Water Institute tahun 2021, tingkat konsumsi air bersih sebelum dan selama pandemi Covid-19 khusus untuk cuci tangan meningkat secara signifikan hampir 3 kali lipat. Jumlah air yang tinggi pada musim penghujan tidak sebanding dengan kesempatan penyerapan air ke dalam tanah. Air hujan yang mengalir di permukaan tanah yang tidak terkendali berpotensi menyebabkan bencana sehingga dibutuhkan manajemen air yang terpadu agar tercipta keseimbangan dalam pemanfaatan air. Salah satu cara mewujudkannya adalah dengan menerapkan konsep panen air hujan (rainwater harvesting) yang dilaksanakan bersama masyarakat di mushola Baiturrahman Kelurahan Tegalsari Kecamatan Walantaka Kota Serang. Sosialisai kegiatan melalui pendekatan metode Participatory Rural Appraisal (PRA) dengan mengajak masyarakat untuk ikut berpartisipasi. Hasil kegiatan pengabdian diantaranya 1) pembuatan alat pemanenan air hujan untuk alternatif kebutuhan air bersih cuci tangan dan desain alat yang direkomendasikan 2) implementasi teknologi rainwater harvesting 3) publikasi media massa 4) hak cipta. Indikator keberhasilan kegiatan ini adalah meningkatnya pemahaman masyarakat tentang strategi pembangunan kota berkelanjutan dengan daur ulang air hujan menjadi air baku (water circulating complex) dan ikut berperan langsung dalam memasyarakatkan gerakan nasional kemitraan penyelamatan air (GNKPA).