bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ciliary Gland Adenocarcinoma of the Eyelid Arising in Hidrocystoma: Case Report and Review of Previously Reported Cases
Authors: Malkova Kseniia , Tschen Jaime 
Published: June 2022

Abstract:
Moll gland is a modified tubular-shaped apocrine sweat gland, which is located on the margin of the eyelid. Moll glands are also known as ciliary glands. The function of these glands was not well known for a long time. However, based on the different studies, it was proved that Moll glands are active from birth and have local immunologic function producing immunoglobulin A. We present a case of Moll adenocarcinoma, a type of apocrine carcinoma, arising from the right upper eyelid of a 57-year-old man. Although Moll gland cysts are frequently seen, this type of adnexal malignancy is extremely uncommon. These tumors can have variable presentation and behavior from less invasive forms to highly malignant metastatic recurrent lesions.
Eccrine Squamous Syringometaplasia Associated With Lichen Sclerosus et Atrophicus
Authors: Mishlab Salih , Cohen Itzhak , Bergman Reuven 
Published: June 2022

Abstract:
Eccrine squamous syringometaplasia (ESS) has been associated with several conditions including morphea, linear scleroderma, and burns. It is yet to be reported in lichen sclerosus et atrophicus (LSA). We describe a bullous LSA plaque on the forearm of a woman with pre-existing genital LSA and vitiligo. Besides the histopathological findings of bullous LSA, numerous small irregular squamoid structures were present in the mid and upper dermis always above the normal eccrine glands. The histopathology, periodic acid–Schiff stain, and positive immunostains for P63, low molecular weight keratins 8&18, epithelial membrane antigen, and carcinoembryonic antigen supported the diagnosis of ESS. The pathogenesis of ESS in LSA may be related to ischemia, inflammation, and fibrosis.
ANOMALIES OF CHOROIDAL VENOUS STRUCTURE IN HIGHLY MYOPIC EYES
Authors: Lu Hongshuang , Du Ran , Xie Shiqi , Xiong Jianping , Chen Changyu , Moriyama Muka , Igarashi-Yokoi Tae , Takahashi Hiroyuki , Kamoi Koju , Uramoto Kengo , Nakao Noriko , Ohno-Matsui Kyoko 
Published: June 2022

Purpose:
To identify anomalies of choroidal venous structure in highly myopic (HM) eyes.

Methods:
Widefield indocyanine green angiographic images of 175 HM eyes (refractive error ≤ –6.0D diopters or axial length >26.5 mm) and 100 control eyes taken between January 2014 and December 2018 were reviewed.

Results:
There were no significant differences in age and gender between HM patients and controls. Three types of changes of large choroidal veins were found in 103 HM eyes (58.86%): Asymmetry of vortex veins in 44 eyes (25.14%), isolated long vein across the macula in 58 eyes (33.14%), and intervortex anastomoses in 25 eyes (14.29%). Similar changes in controls were found in 12 eyes (12%), 0 eye (0%), and 2 eyes (2%), respectively, which were significantly lower than those in the HM group (all P < 0.05). The patterns of asymmetry were affected by steeper staphyloma edges and anastomoses were observed through large trunks and terminal venules. In two eyes with large trunk anastomosis, attenuation of the less dominant vortex vein was observed afterward.

Conclusion:
Choroidal venous anomalies are more common in HM eyes than controls. Choroidal venous structure in HM eyes may be altering continuously, and such changes may underlie the development of myopic maculopathy.
CLINICAL FEATURES AND PROGNOSIS IN IDIOPATHIC EPIRETINAL MEMBRANES WITH DIFFERENT TYPES OF INTRARETINAL CYSTOID SPACES
Authors: Yang Xiaohan , Wang Zengyi , Yu Yanping , Wu Xijin , Qi Biying , Liu Lingzi , Zhang Ke , Wang Xinbo , Liu Wu 
Published: June 2022

Purpose:
To observe the characteristics and prognosis of different types of intraretinal cystoid spaces in idiopathic epiretinal membranes (iERMs).

Methods:
Two hundred and seven consecutive patients with symptomatic iERM who underwent vitrectomy between September 2016 and December 2019 were included. According to spectral-domain optical coherence tomography images, intraretinal cystoid spaces were classified into cystoid macular edema (CME) and microcystic macular edema (MME). Other optical coherence tomography characteristics, including ectopic inner foveal layers, central foveal thickness, and interdigitation zone integrity, were also evaluated.

Results:
Intraretinal cystoid spaces were presented in 30.1% of the iERMs, 21.5% were CME-type, 66.2% were MME-type, and 12.3% were combined-type. Compared with CME, eyes with MME-type and combined-type showed a significantly lower best-corrected visual acuity (BCVA) preoperatively and postoperatively. Cystoid macular edema is always presented in earlier stages (92.9%) and has no significant effects on BCVA (P

Stage I
= 0.927, P

Stage II
= 0.985). Conversely, MME is the primary type in advanced stages associated with a longer duration of symptoms (P = 0.037) and lower preoperative BCVA (P = 0.008). After surgery, cystoid spaces were newly occurred in 33 eyes (21.6%), with no effects on BCVA (P = 0.668). In the multiple regression analysis, the presence of MME was a risk factor for preoperative BCVA (P = 0.001). However, it is not an independent predictor for the postoperative VA.

Conclusion:
Our research further proved that MME is an adverse factor for preoperative and postoperative VA in iERMs. Moreover, we underlined the importance of distinguishing between CME and MME, which may affect prognosis differently.
Prophylactic Clipping to Prevent Delayed Bleeding and Perforation After Endoscopic Submucosal Dissection and Endoscopic Mucosal Resection
Authors: Jiang Wenxi , Cen Li , Dong Caijuan , Zhu Shefeng , Shen Zhe , Li Dong 
Published: June 2022

Background and Aims:
To help prevent delayed adverse events after endoscopic surgery, endoscopists often place clips at the site. This meta-analysis aimed to assess the efficacy and safety of prophylactic clipping in the prevention of delayed bleeding and perforation after endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR).

Methods:
Multiple databases were searched from the inception dates to April 2021. And we included all relevant studies. Pooled odds ratio comparing the prophylactic clipped group versus nonprophylactic clipped group were calculated using the random effects model.

Results:
Twenty-seven articles fulfilled the inclusion criteria, with a total size of 8693 participants. There was statistically significant difference in prophylactic clipping versus no prophylactic clipping for delayed bleeding and perforation found in all studies (odds ratio: 0.35, 95% confidence interval: 0.25-0.49, P<0.01; odds ratio: 0.42, 95% confidence interval: 0.21-0.83, P<0.05; respectively). Besides, statistically significant difference was also found in subgroup analyses based on patients with lesions larger than 20 mm. Prophylactic clipping was more protective for duodenal delayed adverse events than colorectum. The use of clip closure was more protective to ESD-related delayed adverse events than EMR.

Conclusions:
Prophylactic clipping after ESD and EMR was beneficial in preventing delayed bleeding and perforation.
Do Chargemaster Prices Matter?
Authors: Linde Sebastian , Egede Leonard E. 
Published: June 2022

Background:
It remains widely debated whether chargemaster price markups are tied to hospital profitability.

Objective:
To evaluate the effect of chargemaster markups on hospital profitability in the presence of unobserved hospital-specific (time-invariant) confounders, and cross-sectional dependence due to latent (common) policy shocks.

Design:
We use interactive fixed effects methods to address concerns of unobserved hospital-specific (time-invariant) confounders, and cross-sectional dependence.

Setting:
US acute care hospitals, 1996 through 2017 (ie, 22 y).

Participants:
Using primarily Medicare cost report data, we construct an unbalanced panel of 3499 acute care hospitals per year, or a total of 76,972 hospital-year observations.

Measurements:
Chargemaster markups (above cost), profits per hospital inpatient discharge.

Results:
Between 1996 and 2017, chargemaster markups increased (on average) by 155%, and the SD of the chargemaster markup distribution increased by 324%—indicating growing variability in the average markup strategies pursued by hospitals. Our preferred model specification implies that a unit increase of the hospital chargemaster markup is associated with a $261 (P<0.01; 95% confidence interval: $232–$291) increase in profits per hospital inpatient discharge. These results are robust to a wide set of model specifications, the use of alternative profitability measurements, and the use of an alternative instrumental variable identification strategy. Additional subsample analysis that controls for a rich set of hospital quality measures and system affiliation information also yields similar results.

Conclusion:
We show that higher chargemaster markups are associated with higher hospital profitability. Additional research is needed to understand how chargemaster pricing impact health outcomes and health care disparities.
Managing pulmonary arterial hypertension: how to select and facilitate successful transplantation
Authors: Khangoora Vikramjit S. , King Christopher S. , Shlobin Oksana A. 
Published: June 2022

Purpose of review
Despite improvements in available medical therapies, pulmonary arterial hypertension (PAH) remains a progressive, ultimately fatal disorder. Lung transplantation is a viable treatment option for PAH patients with advanced disease.

Recent findings
Recent guidelines from the International Society of Heart and Lung Transplantation (ISHLT) have updated recommendations regarding time of referral and listing for lung transplantation in PAH. The new guidelines emphasize earlier referral for transplant evaluation to ensure adequate time for proper evaluation and listing. They also incorporate objective risk stratification criteria to assist in decision-making regarding timing of referral and listing. With regards to the transplant procedure, bilateral lung transplantation has largely supplanted heart–lung transplantation as the procedure of choice for transplantation for advanced PAH. Exceptions to this include patients with PAH because of congenital heart disease and those with concurrent LV dysfunction. Use of mechanical support via venoarterial ECMO initiated before transplantation and continued into the early postoperative period is emerging as a standard of care and may help to reduce early posttransplant mortality in this population. There has been increased recognition of the importance of WHO Group 3 pulmonary hypertension. Many of the lessons learned from PAH may be applied when transplanting patients with severe WHO Group 3 pulmonary hypertension.

Summary
Patients with PAH present unique challenges with regards to transplantation that require a therapeutic approach distinct from other lung disorders. Lung transplantations for PAH are high-risk endeavors best performed at centers with expertise in management of both PAH and extracorporeal support.
Surgical Removal of Midurethral Sling in Women Undergoing Surgery for Presumed Mesh-Related Complications: A Systematic Review
Authors: Doyle Paula Jaye , Grimes Cara L. , Balk Ethan M. , Wieslander Cecilia , Richardson Monica , Mamik Mamta M. , Sleemi Ambereen , Alas Alexandriah , Kudish Bela , Walter Andrew J. , Aschkenazi Sarit , Mama Saifuddin , Foda Mohamed , Meriwether Kate V. 
Published: June 2022

(Abstracted from Obstet Gynecol 2022;139:277–286)
Because the US Food and Drug administration gave approval for mesh midurethral slings for surgical treatment of female stress incontinence (SUI) in 1996, these synthetic midurethral slings have become procedure of choice for this diagnosis. A systematic review of evidence-based practice guidelines for partial and total removal of these slings after complications was performed by the Society of Gynecologic Surgeons Systematic Review Group.
Sudden Unexpected Death in Epilepsy
Authors: Jordan Richard D. , Coscia Matthew , Lantz Patrick , Harrison William 
Published: June 2022

Abstract
Sudden unexplained death in epilepsy (SUDEP) is the most common cause of death in children and young adults with epilepsy with epileptic patients harboring a 27 times increased risk of death from SUDEP. Structural brain lesions are encountered in up to 50% of autopsy cases. In this case series, we report 3 previously undiagnosed structural causes of SUDEP discovered at autopsy at our institution including schizencephaly, ganglioglioma, and focal cortical dysplasia. Our major recommendation is in cases with suspected SUDEP, formal neuropathological examination and tissue sampling should be employed to identify and characterize specific potential anatomic etiologies.
Effect of Time of Year on Surgical Outcomes in Patients Undergoing Minimally Invasive Sacral Colpopexy or Uterosacral Ligament Suspension
Authors: Renkosiak Kaitlin , Bradley Megan , Dubinskaya Alexandra , Shepherd Jonathan P. 
Published: June 2022

Importance
Academic urogynecologists incorporating fellows/residents into operative cases must ensure safety and quality outcomes throughout the learning curve of the academic year.

Objectives
We evaluated if the month of year relative to fellow/resident promotions in July affects operating time, complications, and prolapse recurrence for minimally invasive sacral colpopexy (MISC) or uterosacral ligament suspension (USLS).

Study Design
This was a retrospective study comprising MISC and USLS from January 2009 to August 2015. Patient demographics, clinical, and surgical data were compared between months with July as month 1. Linear regression assessed operating time. Logistic regression assessed prolapse recurrence (composite of any POP-Q point beyond the hymen, pessary use, or reoperation) and complications.

Results
One thousand seven participants had a mean age of 59.9 ± 9.4, body mass index of 27.6 ± 4.2, gravity of 3.0 ± 1.5, and parity of 2.6 ± 1.1. Most had stage III (67.7%) or II prolapse (25.6%). Minimally invasive sacral colpopexy represented 81.0% (58.8% laparoscopic, 41.2% robotic). Uterosacral ligament suspensions were 68.1% vaginal versus laparoscopic/robotic. Median follow-up was 34 weeks (interquartile range, 11–82). Mean operating time was 199.8 ± 66.4 minutes with no impact by month (P = 0.26). Minimally invasive sacral colpopexy (vs USLS, β = 36.4 minutes), conversion to laparotomy (β = 112.9 minutes), and concomitant hysterectomy (β = 33.4 minutes) increased operating time (P < 0.001). Complications ranged 7.9% (January) to 23.8% (March) with mean of 17.1%. Complications were unaffected by month (odds ratio [OR], 0.99; 95% confidence interval [CI], 0.95–1.04), but USLS had more complications than MISC (OR, 1.55; 95% CI, 1.05–2.28). Prolapse recurred in 9.4% with no impact by month (OR, 0.95; 95% CI, 0.88–1.02). Minimally invasive sacral colpopexy had less recurrence than USLS (OR, 0.33; 95% CI, 0.18–0.60).

Conclusions
Month of year relative to resident/fellow promotion did not affect operating time, complications, or recurrence, debunking the myth of worse outcomes earlier in the academic year.
Environment, animal hosts and human activity on predicting space-time variations of Lyme Borreliosis incidence in France: a Bayesian two-part model
Authors: Fu Wen , Bonnet Camille , Septfons Alexandra , Figoni Julie , Durand Jonas , Frey-Klett Pascale , Rustand Denis , Jaulhac Benoît , Métras Raphaëlle 
Published: June 2022

SummaryBackgroundLyme Borreliosis (LB) is the most widespread hard tick-borne zoonosis in the Northern Hemisphere and shows a seasonal pattern. Existing studies in Europe mainly focused on acarological risk assessment, with very limited investigations exploring human LB occurrence. We aimed to highlight areas and seasons of higher risk for LB occurrence in mainland France, integrating information on meteorological, environmental, animal hosts and human exposure to quantify the associated spatial and temporal risk factors.MethodsWe fitted 2016–19 French LB surveillance data to a two-part spatiotemporal statistical model, defined with binomial and gamma distributions, to explore the factors associated with the presence and increased LB incidence. Shared spatial and temporal random effects were specified using a Besag-York-Mollie model and a seasonal model, respectively. Coefficients were estimated in a Bayesian framework using integrated nested Laplace approximation. Projections and data for 2020 were used for model validation.FindingsLB presence was associated with a high vegetation index (≥0·6). LB incidence increased in areas highly suitable for deer (≥80% cover per area), with mild soil temperatures (10–15°C) in the season preceding the onset, moderate air saturation deficits (3–5 mmHg), and higher proportion of tick bite reports. Prediction maps showed a higher risk of LB in spring and summer (April-September). Substantial geographical variation in LB incidence was found. Higher incidence was reported in parts of eastern, midwestern, and southwestern France.InterpretationThis is the first national-level assessment of seasonal human LB occurrence in Europe allowing to disentangle factors associated with LB presence and increased incidence. This model illustrates a spatial integrated analysis of meteorological, hosts, and anthropogenic factors for a zoonotic and vector-borne infection of major public health concern, and can be used as a reference model to be calibrated in other LB-affected areas.FundingWF is funded by a Sorbonne University PhD fellowship, JD is supported by a grant overseen by the French National Research Agency (ANR) as part of the «Investissements d’Avenir» program (ANR-11-LABX-0002-01, Lab of Excellence ARBRE).
Effectiveness of a telenursing intervention program in reducing exacerbations in patients with chronic respiratory failure receiving noninvasive positive pressure ventilation: A randomized controlled trial
Authors: Shimoyama Makoto , Sato Fumiko , Sato Naoko , Yoshida Shiori , Takahashi Chikako , Inoue Mizue 
Published: June 2022

AbstractTelenursing for patients with chronic respiratory failure receiving noninvasive positive pressure ventilation (NPPV) is an important aid in reducing exacerbations; however, there is insufficient evidence. This randomized controlled trial aimed to investigate the effectiveness of a telenursing intervention program in reducing exacerbations in patients with chronic respiratory failure receiving NPPV at home. This study included patients who were receiving NPPV at home and could handle a tablet device. The intervention group (n = 15) was exposed to an information and communications technology-based telenursing intervention program, in addition to usual care; the control group (n = 16) received the usual care only. The telenursing intervention program comprised telemonitoring and health counseling sessions via videophone. The intervention was evaluated once at enrollment and after 3 months. The primary endpoints were the number of unscheduled outpatient visits, hospitalizations, and hospital days. The secondary endpoints included the St. George’s Respiratory Questionnaire (SGRQ), Euro QOL 5 Dimension, Self-Care Agency Questionnaire (SCAQ), pulmonary function tests, and 6-minute walking distance. We found no significant differences between the intervention and control groups at enrollment. At follow-up, the number of routine outpatient visits for acute exacerbations (r = .36; p = .045), the number of hospitalizations (r = .38; p = .037), the number of hospital days (r = .39; p = .031), SGRQ (r = .36; p = .016), SCAQ (r = .41; p = .019), and 6-minute walking distance (r = .54; p = .030) were significantly different. The increase in the number of unscheduled outpatient visits in the intervention group during follow-up was attributed to acute exacerbations and a significant decrease in the number of hospitalizations and hospital days. Hence, the telenursing intervention program may be effective in reducing exacerbations in patients with chronic respiratory failure receiving NPPV at home.Trial RegistrationUMIN Clinical Trials Registry (UMIN-CTR) UMIN000027657
Persistent Orofacial Pain Attendances at General Medical Practitioners
Authors: Currie CC , Palmer J , Stone SJ , Brocklehurst P , Aggarwal VR , Dorman PJ , Pearce MS , Durham J 
Published: June 2022

AbstractPatients with persistent orofacial pain (OFP) can go through complex care pathways to receive a diagnosis and management, which can negatively impact their pain. This study aimed to describe 44-year trends in attendances at Welsh medical practices for persistent OFP and establish the number of attendances per patient and referrals associated with OFP and factors which may predict whether a patient is referred. A retrospective observational study was completed using the nationwide Secure Anonymised Information Linkage Databank of visits to general medical practices in Wales (UK). Orofacial and migraine Read codes were extracted between 1974 and 2017. Data were analysed using descriptive statistics, univariate, and multivariable logistic regression. Over the 44-year period there were 468,827 persistent OFP and migraine Read codes, accounting for 468,137 patient attendances, or 301,832 patients. The overall attendance rate was 4.22 attendances per 1000 patient-years (95% CI 4.21-4.23). The attendance rate increased over the study period. Almost one-third of patients (n=92,192, 30.54%) attended more than once over the study period and 15.83% attended more than once within a 12-month period. There were 20,103 referral Read codes which were associated with 8,183 patients, with over half these patients being referred more than once. Odds of receiving a referral were highest in females (OR 1.23; 95% CI 1.17-1.29), in those living in rural locations (OR 1.17; 95% CI 1.12-1.22) and in the least deprived quintile (OR 1.39; 95% CI 1.29-1.48). Odds also increased with increasing age (OR 1.03; 95% CI 1.03-1.03). The increasing attendance may be explained by the increasing incidence of persistent OFP within the population. Current care pathways when these patients do seek care from their GMP could be improved. Referrals could be encouraged at an earlier point and made to the most appropriate place to streamline care pathways which could result in improved patient outcomes.
Lineage BA.2 dominated the Omicron SARS-CoV-2 epidemic wave in the Philippines
Authors: Li Yao-Tsun , Polotan Francisco Gerardo M. , Sotelo Gerald Ivan S. , Alpino Anne Pauline A. , Dolor Ardiane Ysabelle M. , Tujan Ma. Angelica A. , Gomez Ma. Ricci R. , Onza Othoniel Jan T. , Chang Angela Kae T. , Bautista Criselda T. , Carandang June C. , Lim Dodge R. , Dancel Lei Lanna M. , Uy-Lumandas Mayan , Dizon Timothy John R. , Hampson Katie , Daldry Simon , Hughes Joseph , Brunker Kirstyn 
Published: June 2022

AbstractThe Omicron SARS-CoV-2 variant led to a dramatic global epidemic wave following detection in South Africa in November, 2021. The Omicron lineage BA.1 was dominant and responsible for most domestic outbreaks during December 2021-January 2022, whilst other Omicron lineages including BA.2 accounted for the minority of global isolates. Here, we describe the Omicron wave in the Philippines by analysing genomic data. Our results identify the presence of both BA.1 and BA.2 lineages in the Philippines in December 2021, before cases surged in January 2022. We infer that only lineage BA.2 underwent sustained transmission in the country, with an estimated emergence around November 18th, 2021 [95% highest posterior density: November 6-28th], whilst despite multiple introductions BA.1 transmission remained limited. These results suggest the Philippines was one of the earliest areas affected by BA.2, and reiterate the importance of whole-genome sequencing for monitoring outbreaks.