bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted genetic and epigenetic profiling of esophageal adenocarcinomas and non-dysplastic Barrett’s esophagus
Authors: Pinto Rita , Hauge Tobias , Jeanmougin Marine , Pharo Heidi D. , Kresse Stine H. , Honne Hilde , Winge Sara B. , Five May-Britt , Kumar Theresa , Mala Tom , Hauge Truls , Johnson Egil , Lind Guro E. 
Published: June 2022

Abstract
Background
Despite the efforts to describe the molecular landscape of esophageal adenocarcinoma (EAC) and its precursor lesion Barrett’s esophagus (BE), discrepant findings are reported. Here, we investigated the prevalence of selected genetic (TP53 mutations and microsatellite instability (MSI) status) and epigenetic (DNA promoter hypermethylation of APC, CDKN2A, MGMT, TIMP3 and MLH1) modifications in a series of 19 non-dysplastic BE and 145 EAC samples. Additional biopsies from adjacent normal tissue were also evaluated. State-of-the-art methodologies and well-defined scoring criteria were applied in all molecular analyses.

Results
Overall, we confirmed frequent TP53 mutations among EAC (28%) in contrast to BE, which harbored no mutations. We demonstrated that MSI and MLH1 promoter hypermethylation are rare events, both in EAC and in BE. Our findings further support that APC, CDKN2A, MGMT and TIMP3 promoter hypermethylation is frequently seen in both lesions (21–89%), as well as in a subset of adjacent normal samples (up to 12%).

Conclusions
Our study further enlightens the molecular background of BE and EAC. To the best of our knowledge, this is one of the largest studies addressing a targeted analysis of genetic and epigenetic modifications simultaneously across a combined series of non-dysplastic BE and EAC samples.
Effects of dry needling on muscle spasticity of the upper limb in a survivor of traumatic brain injury: a case report
Authors: Sedighimehr Najmeh , Zafarshamspour Saber , Sadeghi Mohammadhassan 
Published: June 2022

Abstract
Background
Survivors of moderate and severe traumatic brain injury typically present with spasticity, an upper motor neuron lesion associated with hyperexcitability of the stretch reflex due to disinhibition of cortical influences on spinal cord circuits and structural and functional changes in skeletal muscle. There is growing evidence supporting the effectiveness of dry needling in abating spasticity.

Case presentation
The present case aims to quantify the effects of dry needling on upper limb spastic muscles in a survivor of severe traumatic brain injury in a 27-year-old Iranian man. The treated muscles were biceps brachii, brachialis, flexor digitorum superficialis and profundus, flexor carpi radialis, flexor carpi ulnaris, opponens pollicis, and adductor pollicis. Outcome measures were evaluated before and 1 hour after the intervention. Our results showed that the patient’s upper limb recovery stage and hand function improved one grade according to Brunnstrom recovery stages. Spasticity assessed using the Modified Modified Ashworth Scale in all movements showed one-grade abatement, except in the forearm pronator. Passive resistance force decreased in all movements except in forearm supination. Active range of motion and passive range of motion increased in all movements except in active and passive forearm supination. Hand dexterity improved in both affected and unaffected hands.

Conclusions
Results shown that dry needling could be a favorable option for reducing spasticity.
Vector textures derived from higher order derivative domains for classification of colorectal polyps
Authors: Cao Weiguo , Pomeroy Marc J. , Liang Zhengrong , Abbasi Almas F. , Pickhardt Perry J. , Lu Hongbing 
Published: June 2022

AbstractTextures have become widely adopted as an essential tool for lesion detection and classification through analysis of the lesion heterogeneities. In this study, higher order derivative images are being employed to combat the challenge of the poor contrast across similar tissue types among certain imaging modalities. To make good use of the derivative information, a novel concept of vector texture is firstly introduced to construct and extract several types of polyp descriptors. Two widely used differential operators, i.e., the gradient operator and Hessian operator, are utilized to generate the first and second order derivative images. These derivative volumetric images are used to produce two angle-based and two vector-based (including both angle and magnitude) textures. Next, a vector-based co-occurrence matrix is proposed to extract texture features which are fed to a random forest classifier to perform polyp classifications. To evaluate the performance of our method, experiments are implemented over a private colorectal polyp dataset obtained from computed tomographic colonography. We compare our method with four existing state-of-the-art methods and find that our method can outperform those competing methods over 4%-13% evaluated by the area under the receiver operating characteristics curves.
Role of MRI in diagnosis of prostate cancer and correlation of results with transrectal ultrasound guided biopsy “TRUS”
Authors: Ahmed Islam Hussien Abd Elaziz , Mohamed Ali Hassan Hend Galal Eldeen , Abo ElMaaty Mohamed El Gharib , ElDaisty El Metwally Shaima El Metwally 
Published: June 2022

Abstract
Background
Prostate cancer is the most common cancer in elderly men, and the second leading cause of cancer-related death in developed countries. For a long time, TRUS is used in screening, diagnosis of prostate lesions. Recently the implementation of multi parametric MRI into a screening program currently seems to be the most promising technique to improve the early detection of prostate cancer.

Results
Thirty Patients were referred from urological outpatient clinics complaining of urological symptoms (dysuria, frequency and urine retention). The study was carried, and the patients were submitted to Ultrasonography, conventional magnetic resonance, diffusion weighted images and MR spectroscopy techniques, these results were correlated with histopathological data. In this study Conventional MRI has moderate sensitivity 81.8% and low specificity 37.3% in diagnosing prostate malignancy. Using of mpMRI combination of diffusion-weighted, Dynamic contrast enhanced and MR spectroscopic imaging is a promising approach for discriminating between benign and malignant lesions in the PZ and increase sensitivity 100% and specificity 96.6% in diagnosing prostate malignancy.

Conclusions
The standard for the definitive diagnosis of prostate cancer is trans-rectal ultrasound biopsy. However, TRUS guided biopsy has a significant sampling error and can miss up to 30% of cancers and may show underestimation of Gleason grade, especially in anteriorly located tumors. It may lead to an increase in complications. MRI has an essential role to play in making safer in diagnosis. It can aid in staging also and surgery or radiation treatment planning. Although T2W MRI has been used widely for diagnosis on the basis of its excellent soft tissue resolution, but its accuracy for the detection and localization of cancer prostate is unsatisfactory. The implementation of multi parametric MRI: MR spectroscopy, Dynamic contrast enhanced and diffusion weighted imaging into a diagnosis program improve the diagnostic performance. These advances are beginning to translate into better treatment selection and more accurate image-guided therapies. In addition, early detection of local recurrence.
The Feedback and Noise of Hiroko Komatsu's Photographic Materialities
Authors: Prichard Franz 
Published: June 2022

Abstract
This article explores the dynamic forms of positive feedback found in Hiroko Komatsu's 2017 photography installation, The Execution of Personal Autonomy. This article details how Komatsu's installation generates an intensive interface among photographed materials and photochemical materialities that constitute a noise-like interface akin to the creative production of feedback in Noise music. As a redistribution of affective attunements that inhere within the urban landscape, this article discusses how Komatsu's photographic forms of feedback offer an evolving site for grasping, and potentially reimagining, the reproductive processes of capitalist society. Komatsu's photographic praxis reveals a novel understanding of photography's own role as a material and affective “infrastructure” critical to the reproductive relations of neoliberal and state capitalism.
When the Archive Becomes a Movement
Authors: Chang Haely 
Published: June 2022

Abstract
The History of Women in Korean Photography I exhibition, held at SeMA, Buk-Seoul Museum of Art, in Seoul, South Korea, from June 29 to September 26, 2021, sheds light on an overlooked history of Korean female photographers from the 1900s to the 1980s. The first section of the exhibition chronicles the emergence of female photographers at the dawn of the twentieth century through a timeline featuring women and a shelf with archival materials covering their works. The second section focuses on ten female photographers active during the 1980s. Although their activities were a part of a larger cultural “movement” of the era, the exhibited photographs suggest multiple readings of the term movement. The female photographers moved beyond the boundary of their nation by traveling abroad to expand their approaches to photography. Upon returning to Korea, they became part of a movement reconceptualizing postmodern photography. Lastly, the exhibition itself was a result of a curatorial movement, one which renders the categories of what can and cannot be reflected in histories of art malleable.
STANDUP database of plantar foot thermal and RGB images for early ulcer detection
Authors: Bouallal Doha , Bougrine Asma , Harba Rachid , Canals Raphael , Douzi Hassan , Vilcahuaman Luis , Arbanil Hugo 
Published: June 2022

In this paper, we provide details of a research database consisting of 415 multispectral images (thermal and RGB images) of plantar foot from healthy (125 images) and diabetic subjects (290 images). The healthy subjects were members of two research laboratories (PRISME in France and IRF-SIC in Morocco). The second group was composed of type II diabetic patients who participated in an acquisition campaign at the Hospital Nacional Dos de Mayo in Lima, Peru, as part of a study on the early detection of ulcers in patients with diabetic foot. The purpose of this article is to describe the recruitment and acquisition protocols as well as the equipment used to help other units create similar databases. Our database was created in the context of the European STANDUP Horizon 2020 project #777661, in which eight scientific research entities and high-tech companies partnered.
Technical Note—Data-Driven Newsvendor Problem: Performance of the Sample Average Approximation
Authors: Lin Meichun , Huh Woonghee Tim , Krishnan Harish , Uichanco Joline 
Published: June 2022

Sample Average Approximation in Data-Driven Newsvendor In the data-driven newsvendor problem, the manager makes sequential inventory decisions while learning the unknown demand distribution based on past demand samples. How does the widely used sample average approximation approach perform in this problem? In “Technical Note—Data-Driven Newsvendor Problem: Performance of the Sample Average Approximation,” Lin, Huh, Krishnan, and Uichanco analyze the performance of the sample average approximation as the time horizon grows, which turns out to be the best possible. The authors also examine how the local flatness of the demand distribution around the optimal order quantity affects the complexity of the problem. They show that the sample average approximation has the best achievable performance in terms of not only the time horizon, but also the local flatness of the demand distribution.
High rate of tibial debonding and failure in a popular knee replacement
Authors: Keohane David , Sheridan Gerard A. , Masterson Eric 
Published: June 2022

Aims Total knee arthroplasty (TKA) is a common and safe orthopaedic procedure. Zimmer Biomet's NexGen is the second most popular brand of implant used in the UK. The primary cause of revision after the first year is aseptic loosening. We present our experience of using this implant, with significant concerns around its performance with regards early aseptic loosening of the tibial component. Methods A retrospective, single-surgeon review was carried out of all of the NexGen Legacy Posterior Stabilized (LPS) TKAs performed in this institute. The specific model used for the index procedures was the NexGen Complete Knee System (Legacy Knee-Posterior Stabilized LPS-Flex Articular Surface, LPS-Flex Femoral Component Option, and Stemmed Nonaugmentable Tibial Component Option). Results Between 2013 and 2016, 352 NexGen TKAs were carried out on 331 patients. A total of 62 TKAs have been revised to date, giving an all-cause revision rate of 17.6% at a minimum of five years. Three of these revisions were due to infection. Overall, 59 of the revisions were performed for aseptic loosening (16.7%) of the tibial component. The tibial component was removed intraoperatively without instrumentation due to significant tibial debonding between the implant-cement interface. Conclusion While overall, we believe that early aseptic loosening is multi-factorial in nature, the significantly high aseptic revision rate, as seen by an experienced fellowship-trained arthroplasty surgeon, has led us to believe that there is a fundamental issue with this NexGen implant design. Continued implant surveillance and rigorous review across all regions using this particular implant is warranted based on the concerning findings described here. Cite this article: Bone Jt Open 2022;3(6):495–501.
Phytochemical screening and GC-MS analysis of bioactive compounds of Blumea balsamifera leaf extracts from South Aceh, Indonesia
Authors: MASYUDI MASYUDI , HANAFIAH MUHAMMAD , RINIDAR RINIDAR , USMAN SAID , MARLINA MARLINA 
Published: June 2022

Abstract. Masyudi, Hanafiah M, Rinidar, Usman S, Marlina. 2022. Phytochemical screening and GC-MS analysis of bioactive compounds of Blumea balsamifera leaf extracts from South Aceh, Indonesia. Biodiversitas 23: 1344-1352. Blumea balsamifera is a traditional herbal medicine that has been used worldwide. It is also known as Capa leaf in Aceh, Indonesia. B. balsamifera has been used by the local community for wound healing, anti-bacterial, and anti-inflammation. However, there is no study so far attempting to identify the chemical compounds of B. balsamifera leaves from Aceh. The present study thus aimed to analyze the chemical compounds of B. balsamifera leaves from Aceh. In this study, the B. balsamifera leaves were collected from Gunongpulo village, South Aceh, Indonesia. The extraction process was performed using the maceration method. The active chemical compounds in the B. balsamifera leaf extracts with n-hexane, ethyl acetate, and ethanol solvents were analyzed through phytochemical screening, Fourier Transform Infrared (FTIR) Spectroscopy Analysis and GC-MS. The results showed that B. balsamifera leaf extracts with ethanol and ethyl acetate solvents contain saponins, flavonoids, phenolics, tannins, and steroids, identified through the phytochemical screening. Meanwhile, the extract of B. balsamifera leaves with n-hexane solvent was found to contain steroids, phenolics, and tannins. Twenty-four chemical compounds in the B. balsamifera leaf extract with ethanol were identified using GC-MS. Twenty-eight and twenty-seven chemical compounds were also identified in the B. balsamifera leaf extracts with ethyl acetate and n-hexane solvents, respectively. The most abundant compounds found in the B. balsamifera leaf extracts with ethanol, ethyl acetate, and n-hexane solvents were 2,5-Dimethoxyacetophenone (11.61%), Borneol (14.48%), and Jasmoline (14.32%), respectively. These compounds are members of the flavonoid group which are effective for antibacterial, anti-inflammation, and wound healing applications.
Production and characterization of Imperata cylindrica paper using potassium hydroxide as pulping agent
Authors: Madung Zuliana , Soloi Sabrina , Abdul majid Mohd hafiz , SARJADI MOHD SANI 
Published: June 2022

Abstract. Madung Z, Soloi S, Majid MHA, Sarjadi MS. 2022. Production and characterization of Imperata cylindrica paper using potassium hydroxide as pulping agent. Biodiversitas 23: 1490-1494. Non-woody plants have become an alternative fiber in paper production as woods, the primary sources of papers have become limited due to increasing demand of paper year by year. Imperata cylindrica or cogon grass as the source of fiber for the pulp and paper industry in replacing the wood fiber because it has high cellulose and low lignin content. In this study, cogon grasses were treated with various concentrations of potassium hydroxide, KOH (5%, 8%, 10% and 12%). The effects of alkali treatment on the properties of the papers were investigated in the present study. Scanning Electron Microscope (SEM) image of the paper sheet indicates that the amount of cellulose fiber and other materials were lessening toward a higher concentration of KOH treatment. This explained that most of the lignin was entirely removed and some cellulose probably degraded at higher KOH concentrations. Fourier Transform Infa-Red (FTIR) analysis showed that the peaks at range 1650 cm-1-1630 cm-1 attributed to the presence of v(C=C) aromatic ring of lignin disappeared at 10% and 12% of KOH. The mechanical strength of the papers decreased with an increasing concentration of KOH, while 5% of KOH produced the highest value of tensile strength.
The growth and yield responses of two bean cultivars to organic and inorganic nitrogen sources
Authors: PANGARIBUAN DARWIN H. , ERMAWATI ERMAWATI , SURYANI NI MADE WIDI , MARIA WAHYU SARA 
Published: June 2022

Abstract. Pangaribuan DH, Ermawati, Suryani NMW, Maria WS. 2022. The growth and yield responses of two bean cultivars to organic and inorganic nitrogen sources. Biodiversitas 23: 1677-1682.The productivity of beans is increased by selecting the best cultivar and applying fertilizers according to the needs of the plant. In addition,the application of high-yielding cultivar and N fertilizers with the right dosage could be used to increase the yield. Therefore, the objective of thisstudy is to determine the effect of nitrogensources on the growth and yieldof two bean cultivars. A5×2 factorial treatment was usedin a randomized block design with three replications. The first factor is the Perkasa and Lebat-3 cultivar, the second is organic and inorganic nitrogen fertilizer, namely control, urea 100kgha-1, as well as 10, 20, and 30% concentrationsof liquid organic fertilizer from leucaena leaves. The results showed that the use of liquid organic fertilizers derived from leucaena could be used as an alternative to nitrogenfertilization. Furthermore,the 20% concentrationtreatment producedthe highest number of trifoliate leaves (8.81 leaves) and dry weight (4.52 g). Based on the results,the use of 20% liquid organic fertilizer withPerkasa cultivar showed the best effect on the number of pods per plant (13.38),and yield(846.67 kg ha-1). The technology of liquid organic fertilizers from leucaena leaves could be recommended for bean organic production.
Vetiver root cohesion at different growth sites in Bogor, Indonesia
Authors: FATA YULIA AMIRUL , HENDRAYANTO HENDRAYANTO , ERIZAL ERIZAL , TARIGAN SURIA DARMA , WIBOWO CAHYO 
Published: June 2022

Abstract. Fata YA, Hendrayanto, Erizal, Tarigan SD, Wibowo C. 2022. Vetiver root cohesion at different growth sites in Bogor, Indonesia. Biodiversitas 23: 1683-1692.The plant root system, including the root system of vetiver grass, plays a critical role in enhancing soil cohesion, shear strength, and vegetated slope stability. Numerous studies on mechanical reinforcement of vetiver grass-roots have been conducted, with the majority of studies focusing on ground-planted vetiver with good maintainedor naturally grown vetiver, while mechanical reinforcement of vetiver grass roots planted in landslide areas at various growth sites with less maintenance is still uncommon.The purpose of this study was to examine the vetiver grass-roots cohesion that grew in the different growth sites that had been affected by landslides. Vetiver grass root samples were collected in January 2021, at the age of 8 months. Vetiver grass roots were collected from vetiver plants growing in the affected landslide areas of (a) bareland, (b) shrubland, and (c) bushland. The root tensile strength of root samples was determined using a Universal Testing Machine (UTM) with a capacity of 3 tons, and the measurement accuracy of the load cell was 1/10000. The test was conducted in accordance with ASTM D638-14 guidelines. Three repetitions were performed on roots representing the root length class of 10 cm. The results indicated that the growth sites influenced the morphological and architectural properties of the vetiver grass-roots. The vetiver grass that grew in bushland exhibited a higher root density than bareland or shrubland. The roots were denser and had a greater range of lengths. Short roots less than 10 cm in length were the most prevalent, and the majority of them were found near the soil surface. The greater the soil depth, the less the quantity of roots.The tensile strength (TR) tends to get smaller with longer roots, and vetiver grass rootsgrew in bareland have the highestTR(15-59 MPa) relative to their growth in bushland (9-37 MPa) and shrubland (16-29 MPa). The ratio of root fiber area to root growth area (RAR) also tends to get smaller with deeper roots. Likewise, is the tensile strength increasing caused by roots (tR) and root cohesion (CR) which are a function of RAR. The CR??of vetiver roots growing in bushland (0.015-0.275 kPa) were relatively higher than those growing in bareland (0.02-0.168 kPa) and shrubland (0.002-0.028 kPa) in the same root length class, at the same depth.
Photonic Moiré lattice waveguide with a large slow light bandwidth and delay-bandwidth product
Authors: Nasidi Ibrahim , Hao Ran , Chen Jun , Li Erping , Jin ShangZhong 
Published: June 2022

We proposed an effective approach to enlarge the slow light bandwidth and normalized-delay-bandwidth product in an optimized moiré lattice-based photonic crystal waveguide that exhibits intrinsic mid-band characteristics. A flatband corresponding to a nearly constant group index of 34 over a wide bandwidth of 82 nm centered at 1550 nm with near-zero group velocity dispersion was achieved. A large normalized-delay-bandwidth product of 0.5712 with a relative dispersion of 0.114%/µm was obtained, which is a significant improvement if compared with previous results. Our results indicate that the photonic moiré lattice waveguide could advance slow light applications.