bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exact Basilar Artery Occlusion Location Indicates Stroke Etiology and Recanalization Success in Patients Eligible for Endovascular Stroke Treatment
Authors: Mutke Matthias A. , Potreck Arne , Schmitt Niclas , Seker Fatih , Ringleb Peter A. , Nagel Simon , Möhlenbruch Markus A. , Bendszus Martin , Weyland Charlotte S. , Jesser Jessica 
Published: December 2022

Abstract
Introduction
Endovascular stroke treatment (EST) is commonly performed for acute basilar artery occlusion (BAO). We aimed to identify the role of the exact location of BAO in patients receiving EST regarding the stroke etiology, recanalization success and prediction of favorable clinical outcome.

Methods
Retrospective analysis of 191 consecutive patients treated for BAO with EST from 01/2013 until 06/2021 in a tertiary stroke center. Groups were defined according to exact location of BAO in I: proximal third, II: middle third, III: distal third and IV: tip of the basilar artery. Univariate and multivariate analyses were performed for BAO location comparing stroke etiology, recanalization result and favorable clinical outcome according to mRS 0–3 90 days after stroke onset.

Results
Occlusion sides types I–IV were evenly distributed (37, 36, 60 and 58 patients). Types I and II were more often associated with large artery atherosclerosis (50 vs. 10 patients, p < 0.001). Distal/tip occlusion (types III/IV) occurred mostly in cardiac embolism or embolic stroke of unknown source (89 vs. 12 in types I/II, p < 0.001). Occlusion site correlated with the underlying stroke etiology (AUC [Area under the curve] 0.89, p < 0.0001, OR [odds ratio] for embolism in type IV: 245). Recanalization rates were higher in patients with distal occlusions (type III/IV OR 3.76, CI [95% confidence interval] 1.51–9.53, p = 0.0076). The BAO site is not predicting favorable clinical outcome.

Conclusion
The exact basilar artery occlusion site in patients eligible for endovascular stroke treatment reflects the stroke etiology and is associated with differing recanalization success but does not predict favorable clinical outcome.
Economic integration and FDI location: Is there a border effect within the enlarged EU?
Authors: Serwicka Ilona Elzbieta , Jones Jonathan , Wren Colin 
Published: December 2022

AbstractThis paper examines how integration affects Foreign Direct Investment location in relation to a newly internalised border. It focuses on the fifth European Union enlargement that integrated the Central and Eastern European Countries. Using a spatial autoregressive model, 35,103 FDI location decisions are analysed for Europe at a NUTS-2 regional level over 1997–2010. It finds no distance effect in FDI location prior to enlargement, but after this time FDI is 37% higher in the CEEC regions that are contiguous with the newly internalised border. This is not explained by a national border effect that occurs throughout the union, nor by a drop in FDI in the border regions of the old Member States, but rather it is consistent with improved market access from the removal of the border checks. Along the internalised border it amounts to an extra 60 FDI projects and 13,600 gross jobs per annum, which is up to 2000 investments in the long-run. The results have implications for economic development and cohesion of the enlarged union.
Primary versus deferred ureteroscopy for the management of obstructive anuria secondary to ureteric urolithiasis in children: a prospective randomized study
Authors: AbdelRazek Mostafa , Fathi Atef , Mohamed Mostafa , Abdel-Kader Mohammad S. 
Published: December 2022

AbstractTo compare the role of primary and deferred ureteroscopy (URS) in the management of obstructive anuria secondary to ureteric urolithiasis in pediatric patients. This prospective randomized study included 120 children aged ≤ 12 years who presented with obstructive anuria secondary to ureteric urolithiasis between March 2019 and January 2021. The children were subdivided into group A, which included children who had undergone primary URS without pre-stenting, and group B, which included children who had undergone URS after ureteric stenting. All children were clinically compensated and sepsis-free. Patients with underlying urological structural abnormalities were excluded. The operative time, improvement of renal functions, stone-free rate, and complications were compared between the two groups. At the 1-month follow-up, urine analysis; kidney, ureter, and bladder radiography; and ultrasonography were performed. The patient characteristics of both groups did not show any significant difference. Primary URS had failed in ten children (16.6%) in group A. Moreover, failure of stenting was noted in six patients (11%) in group B. The mean operative time for group B was significantly lower than that for group A (p ≤ 0.001). The stone-free rate was significantly higher in group B (p ≤ 0.001). The rate of overall complications was higher in group A. Deferred URS is preferable over primary URS in the management of obstructive anuria secondary to ureteric urolithiasis”. In children because of the lower need for ureteric dilatation, higher stone- free rate, shorter procedure time, and lower complication rate.
The diagnostic significance of circulating miRNAs and metabolite profiling in early prediction of breast cancer in Egyptian women
Authors: El-Toukhy Safinaz E. , El-Daly Sherien M. , Kamel Mahmoud M. , Nabih Heba K. 
Published: December 2022

Abstract
Objective
Breast cancer (BC) is one of the most commonly diagnosed solid malignancies in women worldwide.

Purpose
Finding new non-invasive circulating diagnostic biomarkers will facilitate the early prediction of BC and provide valuable insight into disease progression and response to therapy using a safe and more accessible approach available every inspection time. Therefore, our present study aimed to investigate expression patterns of potentially circulating biomarkers that can differentiate well between benign, malignant, and healthy subjects.

Methods
To achieve our target, quantitative analyses were performed for some circulating biomarkers which have a role in the proliferation and tumor growth, as well as, glutamic acid, and human epidermal growth receptor 2 (HER2) in blood samples of BC patients in comparison to healthy controls using qRT-PCR, liquid chromatography/mass spectrometry (LC/MS/MS), and ELISA.

Results
Our findings showed that the two miRNAs (miRNA-145, miRNA-382) were expressed at lower levels in BC sera than healthy control group, while miRNA-21 was expressed at higher levels in BC patients than control subjects. Area under ROC curves of BC samples revealed that AUC of miRNA-145, miRNA-382, miRNA-21, and glutamic acid was evaluated to equal 0.99, 1.00, 1.00 and 1.00, respectively. Besides, there was a significantly positive correlation between miRNA-145 and miRNA-382 (r = 0.737), and a highly significant positive correlation between miRNA-21 and glutamic acid (r = 0.385).

Conclusion
Based on our results, we conclude that the detection of serum miRNA-145, -382 and -21 as a panel along with glutamic acid, and circulating HER2 concentrations could be useful as a non-invasive diagnostic profiling for early prediction of breast cancer in Egyptian patients. It can provide an insight into disease progression, discriminate between malignancy and healthy control, and overcome the use limitations (low sensitivity and specificity, repeated risky exposure, and high cost) of other detecting tools, including mammography, magnetic resonance imaging, and ultrasound.
New statistical deterministic method for estimating human thermal load and sensation — application in the Carpathian region
Authors: Ács Ferenc , Kristóf Erzsébet , Szabó Amanda Imola , Zsákai Annamária 
Published: December 2022

AbstractA new statistical deterministic model is presented for estimating human thermal load and sensation. Human thermal load is simulated in terms of clothing resistance (rcl) and operative temperature (To). The model’s input data are wind speed, air temperature, mass of the human body, body length, sex, age, and the latitude of the site. To is statistically linked to potential evapotranspiration, whilst human thermal perception to rcl. The model has been validated in the Carpathian Mountains region for the period 1971–2000 comparing it with the original deterministic rcl model. Thermal perceptions of the representative Hungarian male and female are estimated by using individual thermal perception–rcl point clouds. Metabolic heat flux density differences between persons are less than 15 Wm−2. Human thermal perception area distribution has a topography-based configuration. The prevailing annual perception of Hungarians (for both men and women) in lowland and hilly areas is “cool,” although “neutral” may also occur; in mountains, perception is mostly “cool” or “cold,” with “very cold” being also possible. In the month of July, the perception type in mountains is “neutral” or “cool” depending on the person. In lowland areas, the methodology cannot be applied since the energy balance is not met. The model can also be applied in other heat-deficient regions if the region-specific operative temperature–potential evapotranspiration and the human-specific thermal perception-rcl statistical relationships are determined for the new region.
How does Tourette syndrome impact adolescents’ daily living? A text mining study
Authors: Atkinson-Clement Cyril , Duflot Marion , Lastennet Eloise , Patsalides Leïla , Wasserman Emma , Sartoris Therese-Marie , Tarrano Clément , Rosso Charlotte , Burbaud Pierre , Deniau Emmanuelle , Czernecki Virginie , Roze Emmanuel , Hartmann Andreas , Worbe Yulia 
Published: December 2022

Abstract
Tourette syndrome is a neurodevelopmental disease in which clinical manifestations are essentially present during childhood and adolescence, corresponding to one of the critical development phases. However, its consequences on the daily lives of young patients have been insufficiently investigated. Here, we aimed to investigate this using a statistical text mining approach, allowing for the analysis of a large volume of free textual data. Sixty-two adolescents with Tourette syndrome participated in an interview in which they discussed their daily life (i) in school, (ii) at home, and (iii) with strangers, (iv) the aspect of Tourette syndrome which caused the most difficulty, and (v) their thoughts regarding their future as adults. Following data pre-processing, these corpora were analyzed separately using the IRAMUTEQ software through factorial correspondence analysis to identify the most commonly recurring topics of each corpus, and their relations with clinical features. The main difficulty corpus was directly related to comorbidities of Tourette syndrome. Daily life at home was correlated with executive functioning. Difficulties at school were related to a higher severity of tics. Thoughts regarding future daily life were worst for the youngest patients and were correlated with executive functioning and a higher depression score. Taken altogether, our results highlighted that social stigma was a pervasive topic among our corpora. From a clinical standpoint, tic severity was especially related to difficulties at school, while comorbidities had a high impact on social daily living and cost for managing both tics and symptoms of comorbidities.

Trial registration
clinicaltrials.gov/ct2/show/NCT04179435.
Equitability and welfare maximization for allocating indivisible items
Authors: Sun Ankang , Chen Bo , Doan Xuan Vinh 
Published: December 2022

AbstractWe study fair allocations of indivisible goods and chores in conjunction with system efficiency, measured by two social welfare functions, namely utilitarian and egalitarian welfare. To model preference, each agent is associated with a cardinal and additive valuation function. The fairness criteria we are concerned with are equitability up to any item (EQX) and equitability up to one item (EQ1). For the trade-off between fairness and efficiency, we investigate efficiency loss under these fairness constraints and establish the price of fairness. From the computational perspective, we provide a complete picture of the computational complexity of (i) deciding the existence of an EQX/EQ1 and welfare-maximizing allocation; (ii) computing a welfare maximizer among all EQX/EQ1 allocations.
Active control of flow past an elliptic cylinder using an artificial neural network trained by deep reinforcement learning
Authors: Wang Bofu , Wang Qiang , Zhou Quan , Liu Yulu 
Published: December 2022

AbstractThe active control of flow past an elliptical cylinder using the deep reinforcement learning (DRL) method is conducted. The axis ratio of the elliptical cylinder Γ varies from 1.2 to 2.0, and four angles of attack α = 0°, 15°, 30°, and 45° are taken into consideration for a fixed Reynolds number Re = 100. The mass flow rates of two synthetic jets imposed on different positions of the cylinder θ1 and θ2 are trained to control the flow. The optimal jet placement that achieves the highest drag reduction is determined for each case. For a low axis ratio ellipse, i.e., Γ = 1.2, the controlled results at α = 0° are similar to those for a circular cylinder with control jets applied at θ1 = 90° and θ2 = 270°. It is found that either applying the jets asymmetrically or increasing the angle of attack can achieve a higher drag reduction rate, which, however, is accompanied by increased fluctuation. The control jets elongate the vortex shedding, and reduce the pressure drop. Meanwhile, the flow topology is modified at a high angle of attack. For an ellipse with a relatively higher axis ratio, i.e., Γ ⩾ 1.6, the drag reduction is achieved for all the angles of attack studied. The larger the angle of attack is, the higher the drag reduction ratio is. The increased fluctuation in the drag coefficient under control is encountered, regardless of the position of the control jets. The control jets modify the flow topology by inducing an external vortex near the wall, causing the drag reduction. The results suggest that the DRL can learn an active control strategy for the present configuration.
Impact of ionizers on prevention of airborne infection in classroom
Authors: Ren Chen , Haghighat Fariborz , Feng Zhuangbo , Kumar Prashant , Cao Shi-Jie 
Published: December 2022

AbstractInfectious diseases (e.g., coronavirus disease 2019) dramatically impact human life, economy and social development. Exploring the low-cost and energy-saving approaches is essential in removing infectious virus particles from indoors, such as in classrooms. The application of air purification devices, such as negative ion generators (ionizers), gains popularity because of the favorable removal capacity for particles and the low operation cost. However, small and portable ionizers have potential disadvantages in the removal efficiency owing to the limited horizontal diffusion of negative ions. This study aims to investigate the layout strategy (number and location) of ionizers based on the energy-efficient natural ventilation in the classroom to improve removal efficiency (negative ions to particles) and decrease infection risk. Three infected students were considered in the classroom. The simulations of negative ion and particle concentrations were performed and validated by the experiment. Results showed that as the number of ionizers was 4 and 5, the removal performance was largely improved by combining ionizer with natural ventilation. Compared with the scenario without an ionizer, the scenario with 5 ionizers largely increased the average removal efficiency from around 20% to 85% and decreased the average infection risk by 23%. The setup with 5 ionizers placed upstream of the classroom was determined as the optimal layout strategy, particularly when the location and number of the infected students were unknown. This work can provide a guideline for applying ionizers to public buildings when natural ventilation is used.
The soft-sediment deformation structures and the siliceous concretion presence as indicators of the depositional processes during Middle Paleocene to Middle Eocene in the Apulian Platform Margins in Kefalonia Island, Greece
Authors: Dimopoulos Nikolaos , Zoumpouli Elena , Iliopoulos George , Bourli Nicolina , Zelilidis Avraam 
Published: December 2022

Abstract
Kefalonia Island is situated in western Greece and geologically corresponds to the Apulian Platform Margins (APM), with the Apulian Platform lying to the west and the Ionian Basin to the east. The studied deposits, with a thickness up to 164.5, extend along the 650 m long Agia Efimia bay, ranging from the Middle Paleocene (Selandian) to the uppermost Eocene (Priabonian), during the latest part of the rift stage. Fieldwork measurements of soft-sediment deformation structures (SSDS), paleocurrent directions, the size and abundance of siliceous concretions (SC) and siliceous beds (SB), and shale horizons were correlated with the age of selected samples, and thus, the relation of the tectonic regime with the depositional conditions was presented. As SSDS could represent an indicator of tectonic activity and instability of the basin floor instability, the size and the abundance of the SSDS whereas used to identify the parameters that produced the basin floor instability like the intensity of tectonic activity. The studied section, with a general NE-SW orientation, was subdivided into five (5) different units. The changes of these units in paleocurrent directions, the size, the abundance, and the thickness of SSDS, SC, and SB and the presence of shale horizons in the upper unit, characterize a gradual change of the depositional conditions in the APM, from the Upper Paleocene (Selandian) to the Upper Eocene (Priabonian). The factor that influenced the abovementioned changes was related with the presence and the activity of normal faults that produced instability of the basin floor. Therefore, a reduction in tectonic activity from the Paleocene to the Eocene is suggested.
EasyRights: Information Technology Could Facilitate Migrant Access to Human Rights in a Greek Refugee Camp
Authors: Nikolopoulou Kleopatra , Kehagia Olga , Gavrilut Laura 
Published: December 2022

Abstract
This paper aims to describe the context for the migrant camp in a small municipality, and it discusses the challenge of adopting the easyRights information technology (IT) to make it easier for migrants to exercise their human rights. The easyRights project “Enabling immigrants to easily know and exercise their rights” (https://www.easyrights.eu/) is an ongoing European Horizon 2020 project that addresses the challenge of migrant integration through IT-enabled solutions. This project aims to combine co-creation and intelligent language-oriented technologies to make it easier for migrants to understand and access the services to which they are entitled. The easyRights IT–enabled solutions and toolkits for the implementation of inclusion policies can facilitate the management of the integration of migrants, and improve their autonomy and inclusion. Initial interviews with two stakeholders and one migrant in the city of Kavala (in northern Greece) were conducted. Aspects of the information described in this study are intended to be utilized within the Work Package WP7 of the project, which is with regard to the communication and dissemination plan. We recommend for the easyRights IT tools to be adopted in Kavala, so as to facilitate migrants’ exercise of their human rights, and alleviate the tasks of public administrations and local authorities. Possible solutions to avoid migrant marginalization within Kavala’s municipality include adoption of the easyRights IT solutions and investigation of stakeholders’ and migrants’ use of these technology tools.
A Prototype Network Enhanced Relation Semantic Representation for Few-shot Relation Extraction
Authors: He Haitao , Niu Haoran , Feng Jianzhou , Wang Qian , Wei Qikai 
Published: December 2022

AbstractFew-shot relation extraction is one of the current research focuses. The key to this research is to fully extract the relation semantic information through very little training data. Intuitively, raising the relation semantics awareness in sentences can improve the efficiency of the model to extract relation features to alleviate the overfitting problem in few-shot learning. Therefore, we propose an enhanced relation semantic feature model based on prototype network to extract relations from few-shot texts. Firstly, we design a multi-level embedding encoder with position information and Transformer, which uses local information in the text to enhance the relation semantics representation. Secondly, the encoded relation features are fed into the novel prototype network, which designs a method that utilizes query prototype-level attention to guide the extraction of supporting prototypes, thereby enhancing the prototypes representation to better classify the relations in query sentences. Finally, through experimental comparison and discussion, we prove and analyze the effectiveness of the proposed multi-level embedding encoder, and prototype-level attention can enhance the stability of the model. Furthermore, our model has substantial improvements over baseline methods.
Stability criteria of Samara-like decelerator in unsteady transitions
Authors: Wang H.-C. , Breidenthal R.E. 
Published: December 2022

AbstractThe physics behind the transitions of natural Samaras, or the bio-inspired counterparts, to steady autorotation has been unclear. Theoretical and experimental investigations explore the inertial and aerodynamic characteristics required to guarantee stable transitions of an artificial Samara-like decelerator from chaotic tumbling motions to azimuthal autorotation. A non-dimensional inertial criterion is proposed, which is in accord with experiments.
Small-fibre Neuropathy in Patients with Familial Amyotrophic Lateral Sclerosis Type 8
Authors: Machado-Costa Marcela Câmara , Mitne-Neto Miguel , Costa Luiza Helena Degani , Alves Luciana Moura , Oliveira Acary Souza Bulle , Zatz Mayana , Silva Helga Cristina Almeida 
Published: December 2022

ABSTRACT:Background:Amyotrophic lateral sclerosis (ALS) is a degenerative disease of the nervous system that primarily affects motor neurons. ALS type 8 (ALS8) is a familiar form with predominant involvement of lower motor neurons, tremor, and slow progression.Objective:The aim of this study was to describe sensory involvement in a cohort of ALS8 patients and compare it with the characteristics of sporadic ALS (sALS) patients and controls.Methods:We compared data from 40 ALS8 and 10 sALS patients assessed by neurological evaluation and electrophysiological study. Skin biopsies were performed in these patients and 12 controls for analysis of intraepidermal nerve fiber (IENF) density by protein gene product 9.5 (PGP 9.5) immunohistochemistry.Results:The ALS8 group was younger than the sALS group at the onset of symptoms (p < 0.05) and had a longer disease evolution (p < 0.01). Sensory abnormalities were evident in 35% of the ALS8 and 30% of the sALS patients by neurological examination, and all ALS patients presented normal sensory nerve action potentials. Despite being similar in the ALS8 and sALS groups, IENF density in the ALS8 group was lower than that in the controls (p < 0.0005). In the ALS8 group, IENF density was significantly lower in patients with impairment of vibratory sensation than in those without this finding (p < 0.05) and in females than in males (p < 0.05).Conclusion:Sensory impairment and decreased IENF density are present in ALS8 patients at a frequency and intensity similar to that in the sALS group.