bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetic Ketoacidosis at Onset of Type 1 Diabetes and Long-term HbA1c in 7,961 Children and Young Adults in the Australasian Diabetes Data Network
Authors: Clapin Helen F. , Earnest Arul , Colman Peter G. , Davis Elizabeth A. , Jefferies Craig , Anderson Kym , Chee Melissa , Bergman Philip , de Bock Martin , Kao Kung-Ting , Fegan P. Gerry , Holmes-Walker D. Jane , Johnson Stephanie , King Bruce R. , Mok Meng Tuck , Narayan Kruthika , Peña Vargas Alexia S. , Sinnott Richard , Wheeler Benjamin J. , Zimmermann Anthony , Craig Maria E. , Couper Jenny J. ,   the ADDN Study Group, Ambler Geoff , Andrikopoulos Sof , Barrett Helen , Batch Jenny , Cameron Fergus , Conwell Louise , Cotterill Andrew , Cooper Chris , Donaghue Kim , Fairchild Jan , Fourlanos Spiros , Glastras Sarah , Goss Peter , Gray Leonie , Hamblin Shane , Hofman Paul , Huynh Tony , James Steven , Jones Tim , Lafferty Antony , Martin Michelle , McCrossin Robert , Neville Kris , Pascoe Mark , Paul Ryan , Pawlak Dorota , Phillips Liza , Price Darrell , Rodda Christine , Simmons David , Smart Carmel , Stone Monique , Stranks Steve , Tham Elaine , Ward Glenn , Woodhead Helen 
Published: December 2022

OBJECTIVE
The relationship between diabetic ketoacidosis (DKA) at diagnosis of type 1 diabetes and long-term glycemic control varies between studies. We aimed, firstly, to characterize the association of DKA and its severity with long-term HbA1c in a large contemporary cohort, and secondly, to identify other independent determinants of long-term HbA1c.

RESEARCH DESIGN AND METHODS
Participants were 7,961 children and young adults diagnosed with type 1 diabetes by age 30 years from 2000 to 2019 and followed prospectively in the Australasian Diabetes Data Network (ADDN) until 31 December 2020. Linear mixed-effect models related variables to HbA1c.

RESULTS
DKA at diagnosis was present in 2,647 participants (33.2%). Over a median 5.6 (interquartile range 3.2, 9.4) years of follow-up, participants with severe, but not moderate or mild, DKA at diagnosis had a higher mean HbA1c (+0.23%, 95% CI 0.11,0.28; [+2.5 mmol/mol, 95% CI 1.4,3.6]; P &lt; 0.001) compared with those without DKA. Use of continuous subcutaneous insulin infusion (CSII) was independently associated with a lower HbA1c (−0.28%, 95% CI −0.31, −0.25; [−3.1 mmol/mol, 95% CI −3.4, −2.8]; P &lt; 0.001) than multiple daily injections, and CSII use interacted with severe DKA to lower predicted HbA1c. Indigenous status was associated with higher HbA1c (+1.37%, 95% CI 1.15, 1.59; [+15.0 mmol/mol, 95% CI 12.6, 17.4]; P &lt; 0.001), as was residing in postcodes of lower socioeconomic status (most vs. least disadvantaged quintile +0.43%, 95% CI 0.34, 0.52; [+4.7 mmol/mol, 95% CI 3.4, 5.6]; P &lt; 0.001).

CONCLUSIONS
Severe, but not mild or moderate, DKA at diagnosis was associated with a marginally higher HbA1c over time, an effect that was modified by use of CSII. Indigenous status and lower socioeconomic status were independently associated with higher long-term HbA1c.
In vitro establishment: Monstera acuminata Koch and Monstera deliciosa Liebm
Authors: Casanova Palomeque Nancy Mariel , Bertolini Vincenzo , Iracheta Donjuan Leobardo 
Published: December 2022

The study evaluated the aseptic establishment of Monstera acuminata Koch and Monstera deliciosa Liebm (Araceae) from leaves and the induction of in vitro organogenesis of M. acuminata K. from stem discs of young shoots. For this purpose, different disinfection protocols were applied to mature leaves and young shoots, from which leaf explants of approximately 1 cm2 and stem discs of approximately 1 mm thickness were extracted. The explants were established in semi-solid media with different hormone treatments during the aseptic establishment stage and induction of organogenesis. Disinfection with 3% sodium hypochlorite (NaClO) for 20 min and 50% Murashige and Skoog[1] medium with plant tissue culture preservative (PPM) favored less oxidation in leaf explants of both species. All explants of M. deliciosa in both treatments grown in PPM-added medium and at different disinfection protocols survived, showed no contamination and more than 80% retained cellular activity up to 49 days of culture age. At 35 days of culture, with disinfection in Tween-20 + 20% ethanol + 2.5% NaClO, and seeding of explants in MS medium added with 1 mg/L of BAP, 0.5 mg/L of AIA and 0.1 mg/L of ANA, seven new shoots of stem discs were induced. Monstera deliciosa was more adaptable to in vitro conditions. Advances in aseptic establishment and induction of organogenesis in native Araceae for wicker production are the basis for ex situ conservation of local populations.
Ketamine–dexmedetomidine combined with local anesthesia, with or without different doses of atipamezole in the postoperative period, for orchiectomy in cats
Authors: Gomes Viviane H. , de Carvalho Wagner T. S. , Pimentel Vitor C. , Cappelli Naomi , Mignani Bruna T. G. , da Silva Marta F. A. 
Published: December 2022

Abstract

OBJECTIVE
To evaluate the anesthetic and cardiopulmonary effects of ketamine–dexmedetomidine combined with local anesthesia, associated or not in the postoperative period with different doses of atipamezole, for orchiectomy in cats.

ANIMALS
24 healthy cats.

PROCEDURES
Cats received ketamine (7 mg/kg) combined with dexmedetomidine (10 µg/kg) IM, and 1 mL of saline (group KDSAL), 25 µg/kg (group KDAT25), or 50 µg/kg (group KDAT50) of atipamezole IV, postoperatively. All cats received local anesthesia (2 mg/kg of lidocaine) intratesticular and SC. Physiologic variables were recorded at baseline and at time points during anesthesia. Ketamine rescue dose (1 mg/kg) was recorded. The quality of recovery, the degree of sedation, and side effects were evaluated postoperatively.

RESULTS
2 cats received a single additional bolus of ketamine to perform local anesthesia. Heart rate was lower in KDSAL, KDAT25, and KDAT50 during anesthesia, compared with baseline. Hypertension was observed intraoperatively in all groups. The time to head up, pedal reflex regained time, time to sternal recumbency, and time to standing were shorter in KDAT25 and KDAT50 compared to KDSAL. Lower sedation scores were assigned sooner to KDAT25 and KDAT50 than KDSAL. All groups resulted in low recovery quality scores and no side effects.

CLINICAL RELEVANCE
At the doses used, ketamine–dexmedetomidine combined with local anesthesia allowed the performance of orchiectomy. Rescue dose of ketamine for performing local anesthesia may be required. This combination can result in hypertension. Both atipamezole doses shortened the anesthetic recovery, without differences among them, and side effects.
Investigation of leafy shoots and tea products of European mistletoe (Viscum album L.) with special focus on their antioxidant capacity
Authors: Lantos Ferenc , Ormódi Béla Márton , Makra László , Hajtó Tibor , Süli-Zakar Tímea , Krisch Judit 
Published: December 2022

Abstract
Antioxidants are compounds that inhibit combustion (oxidation) processes. Antioxidants are vital components of our body, which can be obtained in part through plant nutrition. Therefore, it is very important to study species that have significantly higher antioxidant capacity than other species. The aim of the study was to investigate the antioxidant capacity of total polyphenols (TPC) of European mistletoe (Viscum album L.) leafy shoots collected from different species of trees (black locust, European ash, white poplar, field maple and black walnut) based on different methods; DPPH (2,2-diphenyl-1-picrylhydrazyl), FRAP (ferric reducing antioxidant power) and TPC (total phenolic contents). The results proved that the antioxidant effect of leafy shoots from European ash (Fraxinus excelsior) against hydroxyl radicals (ROS) showed significantly higher values than those of the other four tree species. We found that the DPPH, FRAP and TPC methods show significant differences in antioxidant effect of European white mistletoe leafy shoots on the studied tree species and tea brands. However, the FRAP method shows higher sensitivity for trees but for tea brands, the DPPH method is more sensitive. The reason for the difference might be explained by the different methods of drying. In the future, we consider it feasible to plant ash groves at an altitude of at least 80 m above sea level in a closed area, where we can start growing European white mistletoe as an herb. Based on the results obtained European white mistletoe can be recommended as an herb to natural medicine for supplementary treatment of several cancer diseases.
Effects of underlying heart failure on outcomes of COVID-19; a systematic review and meta-analysis
Authors: Morsali Soroush , Rezazadeh-Gavgani Erfan , Oladghaffari Mobina , Bahramian Shirin , Hamzehzadeh Sina , Samadifar Zahra , Enamzadeh Elgar , Sheikhalipour Zahra , Moradi Haniyeh , Pourmehr Hanieh Salehi , Naseri Amirreza , Taban-Sadeghi Mohammadreza , Daneshvar Sara 
Published: December 2022

Abstract

Background: The risk for worse outcomes of COVID-19 (Coronavirus 2019 disease) is higher in patients with cardiac conditions. In this study, we aim to investigate the risks of COVID-19-induced conditions in cases with underlying heart failure.

Methods: We systematically searched PubMed, Scopus, Ovid, ProQuest, Web of Science, and the Cochrane library, to collect the English language articles that investigated patients with underlying heart failure who get infected by COVID-19. The second version of comprehensive meta-analysis (CMA.2) software was used to conduct the meta-analysis.

Results: From 5997 publications, our eligibility criteria were met by 27 studies. Overall, outcomes investigated in all studies include but are not limited to mortality rate, length of hospitalization, need for Intensive care unit (ICU) admission, need for mechanical ventilation, and major cardiovascular conditions. Regarding mortality heart failure patients were more susceptible to death (OR:2.570, 95%CI: 2.085 to 3.169; p-value:<0.001). Also in heart failure patients, the risk of mechanical ventilation was higher (OR:1.707, 95%CI: 1.113 to 2.617; p-value: 0.014).

Conclusion: Pre-existing heart failure is associated with the increased risk of mortality and the need for mechanical ventilation while getting infected with COVID-19. Finding an answer to determine the risk of hospitalization, length of stay, readmission rate, and multiorgan failure is necessary for further development of preventive care and making a plan for providing optimal healthcare facilities for these patients.
Probability Calculation of Upcoming Waves of COVID-19 in Poland
Authors: Arti M.K. , Wiliński Antoni 
Published: December 2022

Abstract
We present the problem of risk estimation/assessment of the new coronavirus (COVID-19) spread in Poland. In the literature, a method is given to explain the COVID-19 disease and try to predict the occurrence of the next wave of COVID-19. A Gaussian composite model is used in literature to identify COVID-19 disease. In this model, however, the prediction of the upcoming waves is dependent primarily on the set of selected samples. For different sets of samples, distinct timings of the upcoming waves are obtained. In this article, we assume that probability is associated with each set of samples, which are used for the prediction of the upcoming waves. By exploring this aspect, it is shown that a better prediction of the upcoming COVID-19 waves can be performed.
Tatalaksana syok septik dengan infeksi intraabdomen et causa perforasi gaster di ICU
Authors: Arianto Dhanu Pitra , Suwarman Suwarman 
Published: December 2022

Latar belakang: Syok septik didefinisikan sebagai bagian dari sepsis didasari oleh gangguan sirkulasi dan sel atau kelainan metabolik yang akan meningkatkan angka mortalitas secara bermakna.Laporan kasus: Laki-laki, 69 tahun, diagnosa syok septik dengan infeksi intrabdomen e.c. perforasi gaster dirawat di ICU setelah dilakukan operasi laparatomi eksplorasi. Pasien mendapatkan tindakan perawatan dengan manajemen sepsis bundle segera setelah diagnosa ditegakkan, menjalani perawatan di icu selama tujuh hari. European Society of Intensive Care Medicine (ESCIM) pada tahun 2018 memperbaharui sepsis bundle dimana dari semua langkah perawatan sepsis awal yang sebelumnya harus diselesaikan dalam 3 dan 6 jam sekarang harus diterapkan dalam 1 jam (1-h bundles), segera setelah diagnosa sepsis ditegakkan. Pada kasus ini pasien dengan keluhan nyeri perut selama satu minggu sebelum masuk rumah sakit, pemeriksaan penunjang darah laktat 4,2 mmol/L, pemeriksaan rontgen abdomen terdapat pneumoperitonium, dilakukan sepsis bundle dalam 1 jam dan laparatomi emergensi. Perawatan dilanjutkan di ICU dengan antibiotik meropenem, support norepineprin dan ventilasi mekanik. Pasien berangsur pulih selama di ICU, ditandai dengan klinis, hasil penunjang laboratorium, dan rontgen yang membaik.Kesimpulan: Pada manajemen pasien sepsis, waktu sangatlah penting. Kecepatan diagnosis, pemberian antibiotik, dan menjaga kestabilan hemodinamik adalah komponen penting untuk mendapatkan luaran yang baik.
Kemampuan manajemen waktu mahasiswa tahap profesi Fakultas Kedokteran Universitas Tarumanagara
Authors: Hanafi Carine Nadia , Widjaja Yoanita 
Published: December 2022

Kemampuan manajemen waktu penting bagi mahasiswa untuk melakukan perencanaan belajar, memrioritaskan pekerjaan yang lebih penting dan persiapan ujian. Mahasiswa kedokteran tahap profesi memiliki kegiatan yang sangat padat dan lebih rentan terhadap ketidakteraturan waktu. Namun studi tentang kemampuan manajemen waktu pada mahasiswa kedokteran tahap profesi masih sangat sulit ditemukan. Studi ini dilakukan untuk mengetahui kemampuan manajemen waktu dan gambarannya berdasarkan faktor-faktor yang berpengaruh pada mahasiswa Fakultas Kedokteran Universitas Tarumanagara tahap profesi. Studi ini merupakan studi deskriptif dengan metode potong lintang pada 112 mahasiswa Fakultas Kedokteran Universitas Tarumanagara tahap profesi yang sudah menyelesaikan semua mata kepaniteraan. Kemampuan manajemen waktu dinilai menggunakan kuesioner skala manajemen waktu yang telah divalidasi dalam Bahasa Indonesia. Kemampuan manajemen waktu responden terbagi dalam tiga kategori, 21 orang (18,8%) tergolong kategori tinggi, 89 orang (79.5%) kategori sedang dan 2 orang (1,8%) termasuk dalam kategori rendah. Mahasiswa berjenis kelamin perempuan dan yang memiliki motivasi diri dalam pembelajaran cenderung menunjukkan manajemen waktu yang lebih tinggi. Mayoritas mahasiswa Fakultas Kedokteran Universitas Tarumanagara tahap profesi memiliki kemampuan manajemen waktu sedang.
Hubungan durasi mengemudi dengan risiko suspect carpal tunnel syndrome pada ojek online
Authors: Sari Mutiara Fatika , Novendy Novendy 
Published: December 2022

Salah satu penyakit akibat kerja yang sering terjadi adalah carpal tunnel syndrome (CTS). Faktor-faktor yang berpengaruh adalah postur pergelangan tangan dalam keadaan fleksi dan ekstensi yang terlalu ekstrim, penggunaan otot fleksi repetitif, dan tereksposnya pergelangan tangan terhadap getaran dalam jangka waktu lama. Pengemudi ojek online merupakan salah satu pekerjaan yang berpotensi lebih mudah dan sering mengalami paparan. Saat mengendarai motor, tangan melakukan gerakan yang bersifat repetitif dengan postur pergelangan tangan dalam keadaan fleksi maupun ekstensi saat memegang handle bar (setang). Tujuan dari studi ini untuk mengetahui hubungan durasi mengemudi dengan suspect carpal tunnel syndrome pada pengemudi ojek online sehingga dapat dilakukan pencegahan di kemudian hari. Studi ini menggunakan metode analitik observasional dengan pendekatan potong lintang. Instrument yang digunakan berupa Boston Carpal Tunnel Syndrome Questionnaire (BCTQ). Total jumlah responden pada studi ini adalah 193 orang. Berdasarkan data durasi mengemudi, terdapat 118 (61,1%) responden mengemudi ? 10 jam/hari responden, dan 75 (38.9%) responden selama <10 jam/hari. Sebanyak 93 (78.8%) responden memiliki suspect CTS dan 25 (21.2%) responden tidak memiliki suspect CTS. Berdasarkan analisis bivariat, didapatkan p-value 0.949 dan PR 1.019, yang berarti tidak ada hubungan yang bermakna antara durasi mengemudi dengan risiko suspect carpal tunnel syndrome pada ojek online.
<p>"Ándate al páramo": prácticas lingüísticas de exclusión y prejuicios en contra de los indígenas en la interacción interétnica en Twitter (Ecuador)</p>
Authors: Placencia Maria Elena 
Published: December 2022

Este artículo examina las prácticas lingüísticas de usuarios de Twitter mediante las cuales se intenta discriminar y excluir a indígenas en el contexto ecuatoriano y los prejuicios detrás de estas prácticas. Para el estudio se seleccionaron las cuentas de tres líderes indígenas, activos en Twitter, y se construyó un corpus basado en las respuestas que los usuarios dan a los tuits de estos líderes (2944 respuestas); se recogieron los datos en un período de tiempo durante de las elecciones presidenciales de 2021. El enfoque adoptado es el de la pragmática crítica al buscar desvelar prácticas discriminatorias en contra de minorías, tomando en cuenta en este caso el contexto histórico y político de su ocurrencia. Partiendo de trabajos sobre agravios (‘slurs’) (ej. Croom 2011) e insultos raciales (ej. Guimarães 2003), se identificaron 329 instancias de este tipo de insultos, que luego se agruparon temáticamente, de acuerdo con las creencias negativas sobre la identidad indígena que parecen (re)crear (ej. que los indígenas son ignorantes, que no tienen higiene, etc.). El estudio muestra que el racismo a través del lenguaje, que se ha observado en interacciones cara a cara (v. p. ej., De la Torre 2002; Placencia 2008) se ha extendido en línea, con diversas manifestaciones, tanto convencionales como no convencionales y parece ocurrir sin freno en la plataforma.
Fuzzy Translation and Fuzzy Multiplication on D-Algebras
Authors: Mohammed Khalid Shahoodh  , Montaser I. Adwan  
Published: December 2022

The concept of fuzzy set (FS) is one of the beautiful branches in Mathematics. This concept was initiated by Zadeh [1]. Since that time, many studies have been considered this concept by different ways in the field of pure and applied Mathematics. In this article, we introduced the notion of FT and FM on a D-algebras where FT is a fuzzy Translation and FM is a fuzzy Multiplication. We proved some characterizations of FT and FM of sub-algebra and d-ideal of a D-algebras Moreover, the notion of FM-αλ-T has been investigated on the D-algebras Furthermore, some results on the d-homomorphism of FT and FM which based on the fuzzy d-ideal of a D-algebras are presented.
Kepastian Hukum Pelaksanaan Voting Online Rencana Perdamaian Dalam Penundaan Kewajiban Pembayaran Utang
Authors: Cindarbumi Berlian Pramesthi , Suryamah Aam 
Published: December 2022

<p><em>The purpose of this study is to analyze the legal certainty </em><em>of </em><em>implementation </em><em>voting</em><em> online for reconcilliation agreement in the suspension of payment</em><em> scheme. </em><em>During the Covid-19Pandemic, the government issued various policies regarding social activities that would be carried out in court which were carried out </em><em>online</em><em>, now they can be carried out </em><em>online</em><em>, including the agenda for voting </em><em>for </em><em>reconcilliation agreement in PKPU.</em><em> However, there is no legal basis for voting online for </em><em>reconcilliation agreement in PKPU</em><em>, so there is legal uncertainty regarding this implementation. </em><em>The research method used in this research is normative juridical. The results of the research obtained are that there is certainty from the implementation of voting </em><em>online for reconciliation agreement in the suspension of payment </em><em>scheme by referring to SEMA No. 1 of 2020 as legitimacy which states that judges can carry out activities in court boldly in order to reduce the spread of Covid-19. The implementation of the online voting </em><em>online for reconciliation agreement </em><em>as a whole still refers to the </em><em>UU KPKPU</em><em> and </em><em>thats</em><em> derivative regulations</em><em>. The novelty of this research is to examine the validity or legal certainty of the implementation of the voting online for </em><em>reconcilliation agreement in PKPU</em><em> scheme.</em></p><p>Penelitian ini bertujuan untuk menganalisis kepastian hukum dari pelaksanaan voting <em>online</em> rencana perdamaian dalam skema penundaan kewajiban pembayaran utang (PKPU). Pada masa pandemi Covid-19, pemerintah mengeluarkan berbagai kebijakan mengenai pembatasan sosial yang mengakibatkan kegiatan di pengadilan yang semula dilaksanakan secara langsung, kini dapat dilakukan secara daring, termasuk agenda voting rencana perdamaian dalam PKPU. Akan tetapi, tidak ditemukan landasan hukum dari voting <em>online</em> rencana perdamaian dalam PKPU, sehingga terdapat ketidakpastian hukum terhadap pelaksanaannya. Metode penelitian yang digunakan dalam penelitian ini adalah yuridis normatif. Hasil penelitian yang didapat ialah bahwa terdapat kepastian hukum dari pelaksanaan voting <em>online</em> rencana perdamaian dalam skema PKPU dengan merujuk kepada SEMA No. 1 Tahun 2020 sebagai legitimasi yang menyebutkan bahwa hakim dapat menyelenggarakan kegiatan-kegiatan di pengadilan secara daring demi menekan angka penyebaran Covid-19. Adapun pelaksanaan dari voting <em>online</em> rencana perdamaian secara keseluruhan masih merujuk kepada UU KPKPU dan peraturan turunannya. Kebaruan dari penelitian ini ialah mengkaji keabsahan atau kepastian hukum terhadap pelaksanaan voting rencana perdamaian secara <em>online</em> dalam skema PKPU.</p><p><strong> </strong></p>