bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Bench-Scale Study on Cuttings-Bed Erosion in Horizontal Wells
Authors: Pedrosa Camilo , Lund Bjørnar , Opedal Nils , Ytrehus Jan David , Saasen Arild 
Published: November 2022

Abstract
Cuttings-beds formation while drilling wellbores is a common challenge, especially for horizontal wells, as drilled particles have higher area to be deposited and form cuttings-beds, which can cause several problems such as increased torque and drag, pipe sticking or pipe breakage, among others. Removal of the drilled cuttings is done by circulating a suitable drilling fluid through the wellbore. This paper presents results from laboratory tests with deposited cuttings-bed and the flow of a fluid to erode the bed. The simulated cuttings-bed is a 1 m long deposited sand-bed in a horizontal section. Three different types of fluids are being used in the tests. To investigate how the rheological properties can affect the erodibility of the cuttings-bed, water (as a Newtonian fluid), a xanthan gum solution, and a water-based drilling fluid prepared for an offshore field operation (as a non-Newtonian fluids) are applied. Ultrasound measurements together with differential bed weight have been used to analyze the fluid–bed interaction. Results have shown that the cuttings-bed is eroded by dune movement. Saltation and dragging of sand particles due to the fluid flow appear to create a crest and then avalanche them down. The different types of fluids undergo different shear rates from the same pump power as the viscosity changes, as well as flow rates dependency along the dune extent.
Influence of Heave Plate on the Flow-Induced Motions of a Floating Offshore Wind Turbine
Authors: Gonçalves Rodolfo T. , Malta Edgard B. , Simos Alexandre N. , Hirabayashi Shinichiro , Suzuki Hideyuki 
Published: November 2022

Abstract
Flow-induce motions (FIM) small-scale model tests were performed for the Jappaku floating offshore wind turbines (JPK), a FOWT developed to operate in Brazilian waters. This paper aims to investigate the presence of FIM on the JPK to show the importance of heave plate (HP) design and to show how HP mitigates FIM. Three different HP dimensions were tested and compared with the condition without HP. In addition, two different incidence angles of the current were tested, namely, 0 deg and 180 deg. The results showed amplitudes in the transverse direction similar to the diameter of the external platform column for the case without HP. These amplitudes are higher than the ones observed for previous deep-draft semi-submersibles found in the literature. Conversely, the largest HP dimensions implied in mitigation of the FIM amplitudes, i.e., very low amplitudes, were observed. The presence of the central column played an essential role in FIM and significantly modified the amplitudes in different current incidences. Due to the different diameters of the external and central columns, the FIM presented two different branches of response related to the vortex-shedding frequency around the columns. The results showed that significant FIM could occur for this specific JPK investigation even with HP. The HP design has a positive effect on reducing dynamic behaviors due to the wave and current incidences. Therefore, its design must be included in the preliminary stages of FOWT developments.
Modeling and Performance Assessment of a Hypothetical Stand-Alone Parabolic Trough Solar Power Plant Supported by Climatic Measurements in Ipoh, Malaysia
Authors: Mohammad Sanan T. , Al-Kayiem Hussain H. , Khlief Ayad K. , Aurybi Mohammed A. 
Published: November 2022

Abstract
This study presents a conceptual design for a concentrated solar power plant by using direct steam generation and a stand-alone power system based on a concentration of solar parabolic troughs. The system is located at the solar research site (SRS) of Universiti Teknologi PETRONAS in Ipoh, Malaysia. The model system uses an integrated turbine with 1.2 kW generators, and steam is generated by a flow loop powered by solar parabolic trough concentrators. An in-situ calculation of normal direct irradiance was conducted in SRS and used as an input for the mathematical model. The model was developed to assess the transient behavior of the system and the behavior of the projected power generation under seasonal variations and daily solar radiation. The parabolic trough power plant achieved the highest average output of 8.85% during the low rainfall season in March.
Nivolumab after selective internal radiation therapy for the treatment of hepatocellular carcinoma: a phase 2, single-arm study
Authors: de la Torre-Aláez Manuel , Matilla Ana , Varela Maria , Iñarrairaegui Mercedes , Reig Maria , Lledó Jose Luis , Arenas Juan Ignacio , Lorente Sara , Testillano Milagros , Márquez Laura , Da Fonseca Leonardo , Argemí Josepmaria , Gómez-Martin Carlos , Rodriguez-Fraile Macarena , Bilbao Jose I , Sangro Bruno 
Published: November 2022

PurposeTo evaluate the safety and efficacy of selective internal radiation therapy (SIRT) in combination with a PD-1 inhibitor in patients with unresectable hepatocellular carcinoma (uHCC) and liver-only disease ineligible for chemoembolization.Patients and methodsNASIR-HCC is a single-arm, multicenter, open-label, phase 2 trial that recruited from 2017 to 2019 patients who were naïve to immunotherapy and had tumors in the BCLC B2 substage (single or multiple tumors beyond the up-to-7 rule), or unilobar tumors with segmental or lobar portal vein invasion (PVI); no extrahepatic spread; and preserved liver function. Patients received SIRT followed 3 weeks later by nivolumab (240 mg every 2 weeks) for up to 24 doses or until disease progression or unacceptable toxicity. Safety was the primary endpoint. Secondary objectives included objective response rate (ORR), time to progression (TTP), and overall survival (OS).Results42 patients received SIRT (31 BCLC-B2, 11 with PVI) and were followed for a median of 22.2 months. 27 patients discontinued and 1 never received Nivolumab. 41 patients had any-grade adverse events (AE) and 21 had serious AEs (SAE). Treatment-related AEs and SAEs grade 3–4 occurred in 8 and 5 patients, respectively. Using RECIST 1.1 criteria, ORR reported by investigators was 41.5% (95% CI 26.3% to 57.9%). Four patients were downstaged to partial hepatectomy. Median TTP was 8.8 months (95% CI 7.0 to 10.5) and median OS was 20.9 months (95% CI 17.7 to 24.1).ConclusionsThe combination of SIRT and nivolumab has shown an acceptable safety profile and signs of antitumor activity in the treatment of patients with uHCC that were fit for SIRT.Trial registration numberNCT03380130
Enhanced efficacy of direct immunochemotherapy for hepatic cancer with image-guided intratumoral radiofrequency hyperthermia
Authors: Kan Xuefeng , Zhou Guanhui , Zhang Feng , Ji Hongxiu , Shin David S , Monsky Wayne , Zheng Chuansheng , Yang Xiaoming 
Published: November 2022

BackgroundIt is still a challenge to prevent tumor recurrence post radiofrequency ablation (RFA) of medium-to-large hepatocellular carcinomas (HCC). Immunochemotherapy, a combination of immunotherapy with chemotherapy, has demonstrated a great potential in augmenting the treatment efficacy for some malignancies. In this study, we validated the feasibility of using radiofrequency hyperthermia (RFH)-enhanced intratumoral immunochemotherapy of LTX-315 with liposomal doxorubicin for rat orthotopic HCC.MethodsDifferent groups of luciferase-labeled rat HCC cells and rat orthotopic HCC models were treated by: (1) phosphate buffered saline; (2) RFH; (3) LTX-315; (4) RFH+LTX-315; (5) liposomal doxorubicin; (6) RFH+liposomal doxorubicin; (7) LTX-315+liposomal doxorubicin; and (8) RFH+LTX-315+liposomal doxorubicin. Cell viabilities and apoptosis of different treatment groups were compared. Changes in tumor sizes were quantified by optical and ultrasound imaging, which were confirmed by subsequent histopathology. The potential underlying biological mechanisms of the triple combination treatment (RFH+LTX-315+liposomal doxorubicin) were explored.ResultsFlow cytometry and MTS assay showed the highest percentage of apoptotic cells and lowest cell viability in the triple combination treatment group compared with other seven groups (p<0.001). Tumors in this group also presented the most profound decrease in bioluminescence signal intensities and the smallest tumor volumes compared with other seven groups (p<0.001). A significant increase of CD8+T cells, CD8+/interferon (IFN)-γ+T cells, CD8+/tumor necrosis factor (TNF)-α+T cells, and natural killer cells, and a significant decrease of regulatory T cells were observed in the tumors (p<0.001). Meanwhile, a significantly higher level of Th1-type cytokines in both plasma (interleukin (IL)-2, IL-12, IL-18, IFN-γ) and tumors (IL-2, IL-18, IFN-γ, TNF-α), as well as a significantly lower Th2-type cytokines of IL-4 and IL-10 in plasma and tumor were detected.ConclusionsIntratumoral RFA-associated RFH could enhance the efficacy of immunochemotherapy of LTX-315 with liposomal doxorubicin for HCC, which may provide a new strategy to increase the curative efficacy of thermal ablation for medium-to-large HCC.
Ipilimumab plus nivolumab in avelumab-refractory Merkel cell carcinoma: a multicenter study of the prospective skin cancer registry ADOREG
Authors: Glutsch Valerie , Schummer Patrick , Kneitz Hermann , Gesierich Anja , Goebeler Matthias , Klein Detlef , Posch Christian , Gebhardt Christoffer , Haferkamp Sebastian , Zimmer Lisa , Becker Jürgen C , Leiter Ulrike , Weichenthal Michael , Schadendorf Dirk , Ugurel Selma , Schilling Bastian 
Published: November 2022

Merkel cell carcinoma is a rare, highly aggressive skin cancer with neuroendocrine differentiation. Immune checkpoint inhibition has significantly improved treatment outcomes in metastatic disease with response rates to programmed cell death protein 1/programmed cell death 1 ligand 1 (PD-1/PD-L1) inhibition of up to 62%. However, primary and secondary resistance to PD-1/PD-L1 inhibition remains a so far unsolved clinical challenge since effective and safe treatment options for these patients are lacking.Fourteen patients with advanced (non-resectable stage III or stage IV, Union international contre le cancer 2017) Merkel cell carcinoma with primary resistance to the PD-L1 inhibitor avelumab receiving subsequent therapy (second or later line) with ipilimumab plus nivolumab (IPI/NIVO) were identified in the prospective multicenter skin cancer registry ADOREG. Five of these 14 patients were reported previously and were included in this analysis with additional follow-up. Overall response rate, progression-free survival (PFS), overall survival (OS) and adverse events were analyzed.All 14 patients received avelumab as first-line treatment. Thereof, 12 patients had shown primary resistance with progressive disease in the first tumor assessment, while two patients had initially experienced a short-lived stabilization (stable disease). Six patients had at least one systemic treatment in between avelumab and IPI/NIVO. In total, 7 patients responded to IPI/NIVO (overall response rate 50%), and response was ongoing in 4 responders at last follow-up. After a median follow-up of 18.85 months, median PFS was 5.07 months (95% CI 2.43—not available (NA)), and median OS was not reached. PFS rates at 12 months and 24 months were 42.9% and 26.8 %, respectively. The OS rate at 36 months was 64.3%. Only 3 (21%) patients did not receive all 4 cycles of IPI/NIVO due to immune-related adverse events.In this multicenter evaluation, we observed high response rates, a durable benefit and promising OS rates after treatment with later-line combined IPI/NIVO. In conclusion, our patient cohort supports our prior findings with an encouraging activity of second-line or later-line IPI/NIVO in patients with anti-PD-L1-refractory Merkel cell carcinoma.
Public willingness to participate in population DNA screening in Australia
Authors: Tiller Jane M , Bakshi Andrew , Brotchie Adam R , Green Robert C , Winship Ingrid M , Lacaze Paul 
Published: November 2022

BackgroundPopulation-based DNA screening for medically actionable conditions has the potential to improve public health by enabling early detection, treatment and/or prevention; however, public attitudes and willingness to participate in DNA screening have not been well investigated.MethodsWe presented a scenario to members of the Australian public, randomly selected from the electoral roll via the Australian Survey of Societal Attitudes, describing an adult population DNA screening programme currently under development, to detect risk of medically actionable cancers and heart disease. We asked questions regarding willingness to participate and pay, preferred delivery methods and concerns.ResultsWe received 1060 completed questionnaires (response rate 23%, mean age 58 years). The vast majority (>92%) expressed willingness to undertake DNA screening. When asked about the optimal age of screening, most (56%) favoured early adulthood (aged 18–40 years) rather than at birth or childhood. Many respondents would prefer samples and data be kept for re-screening (36%) or research use (43%); some preferred samples to be destroyed (21%). Issues that decrease likelihood of participation included privacy (75%) and insurance (86%) implications.ConclusionOur study demonstrates public willingness to participate in population DNA screening in Australia, and identifies barriers to participation, to be addressed in the design of screening programmes. Results are informing the development of a pilot national DNA screening programme.
Impairments to executive function in emerging adults with Huntington disease
Authors: Pfalzer Anna C , Watson Kelly H , Ciriegio Abagail E , Hale Lisa , Diehl Spencer , McDonell Katherine E , Vnencak-Jones Cindy , Huitz Elizabeth , Snow Abigail , Roth Marissa C , Guthrie Cara S , Riordan Heather , Long Jeffrey D , Compas Bruce E , Claassen Daniel O 
Published: November 2022

Background and objectivesThe clinical diagnosis of Huntington disease (HD) is typically made once motor symptoms and chorea are evident. Recent reports highlight the onset of cognitive and psychiatric symptoms before motor manifestations. These findings support further investigations of cognitive function across the lifespan of HD sufferers.MethodsTo assess cognitive symptoms in the developing brain, we administered assessments from the National Institutes of Health Toolbox Cognitive Battery, an age-appropriate cognitive assessment with population norms, to a cohort of children, adolescents and young adults with (gene-expanded; GE) and without (gene-not-expanded; GNE) the trinucleotide cytosine, adenine, guanine (CAG) expansion in the Huntingtin gene. These five assessments that focus on executive function are well validated and form a composite score, with population norms. We modelled these scores across age, and CAP score to estimate the slope of progression, comparing these results to motor symptoms.ResultsWe find significant deficits in the composite measure of executive function in GE compared with GNE participants. GE participant performance on working memory was significantly lower compared with GNE participants. Modelling these results over age suggests that these deficits occur as early as 18 years of age, long before motor manifestations of HD.ConclusionsThis work provides strong evidence that impairments in executive function occur as early as the second decade of life, well before anticipated motor onset. Future investigations should delineate whether these impairments in executive function are due to abnormalities in neurodevelopment or early sequelae of a neurodegenerative process.
Adult-onset epilepsy and risk of traumatic brain injury: a nationwide cohort study
Authors: Posti Jussi P , Ruuskanen Jori O , Kytö Ville 
Published: November 2022

BackgroundA knowledge gap exists regarding the risk of traumatic brain injury (TBI) in patients with epilepsy.MethodsPatients with adult-onset epilepsy during 2005–2018 in Finland were studied using retrospective longitudinal national registry-linkage design. Patients with epilepsy (n=35 686; 51% men; mean age 56.6 years) were 1:1 matched to non-epileptic controls by age, sex, comorbidity burden and cohort entry year. The primary outcome was TBI leading to admission or death, secondary outcomes were TBI admission, fatal TBI, acute neurosurgical operations (ANOs) for TBI and TBI recurrence.ResultsThe cumulative rate of the primary endpoint was 1.2% at 1 year, 5.6% at 10 years and 7.3% at 14 years in the epilepsy group versus 2.9% at 14 years in the matched controls (HR=3.77; p<0.0001). Epilepsy was associated with increased risk of TBI admission (6.9% vs 2.7%; HR=3.96; p<0.0001), ANOs (1.3% vs 0.4%; HR=7.00; p<0.0001) and fatal TBI (1.3% vs 0.5%; HR=3.82; p<0.0001), during follow-up. Competing risk analyses confirmed the association of epilepsy with all outcomes (p<0.0001). Epilepsy was associated with TBI recurrence during follow-up (HR 1.72; p=0.002).ConclusionPatients with adult-onset epilepsy have a significantly increased risk of severe and fatal TBI. The results underline the importance of TBI prevention in epilepsy.
Schwinger–Dyson truncations in the all-soft limit: a case study
Authors: Aguilar A. C. , Ferreira M. N. , Oliveira B. M. , Papavassiliou J. 
Published: November 2022

AbstractWe study a special Schwinger–Dyson equation in the context of a pure SU(3) Yang–Mills theory, formulated in the background field method. Specifically, we consider the corresponding equation for the vertex that governs the interaction of two background gluons with a ghost–antighost pair. By virtue of the background gauge invariance, this vertex satisfies a naive Slavnov–Taylor identity, which is not deformed by the ghost sector of the theory. In the all-soft limit, where all momenta vanish, the form of this vertex may be obtained exactly from the corresponding Ward identity. This special result is subsequently reproduced at the level of the Schwinger–Dyson equation, by making extensive use of Taylor’s theorem and exploiting a plethora of key relations, particular to the background field method. This information permits the determination of the error associated with two distinct truncation schemes, where the potential advantage from employing lattice data for the ghost dressing function is quantitatively assessed.
Effects of Injection Pressure and Duration on Alternate High-Pressure Water-Gas Sequestration of Coalbed Methane
Authors: Li Ke , Zhu Chuanjie , Liu Siyuan , Chen Deliang , Cai Guanghui 
Published: November 2022

To solve the problems of high ground stress, low permeability and low coalbed methane recovery, this paper proposes an optimization technique for improving coal seam permeability, i.e., water-gas alternating displacement enhances coalbed methane recovery (WGA-ECBM). The seepage field of gas-water two-phase flow is derived and a multiphase fluid-solid coupling model between physical parameters is established. This paper studies the effects of three displacement methods (water injection, air injection and water-air alternating injection) on methane recovery. The influence of injection pressure and injection duration on the WGA-ECBM technique is also studied. The

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(methane volume fraction) of the three methods decrease by 17.84%, 12.72% and 44.62% in the borehole, respectively. The influence ranges (diameter) are 24.68 m, 149.73 m and 135.21 m, respectively. Pore pressures and displacement area also increase as injection pressure increases in a 5 MPa gradient. And

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in the borehole decrease by 35.57%, 43.82%, 46.78% and 51.72% from 10 MPa to 25 MPa, respectively. With the increase of injection duration, the influence range expands significantly but the pore pressure distribution changes little. And

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decreases slightly in the displaced area and the displacement velocity gradually slows down. This technique promotes multiphase flow migration in coal seam, and increases the displacement range and methane recovery efficiency.
Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Authors: Matikas Alexios , Johansson Hemming , Grybäck Per , Bjöhle Judith , Acs Balazs , Boyaci Ceren , Lekberg Tobias , Fredholm Hanna , Elinder Ellinor , Margolin Sara , Isaksson-Friman Erika , Bosch Ana , Lindman Henrik , Adra Jamila , Andersson Anne , Agartz Susanne , Hellström Mats , Zerdes Ioannis , Hartman Johan , Bergh Jonas , Hatschek Thomas , Foukakis Theodoros 
Published: November 2022

Abstract

Purpose:
PREDIX HER2 is a randomized Phase II trial that compared neoadjuvant docetaxel, trastuzumab, and pertuzumab (THP) with trastuzumab emtansine (T-DM1) for HER2-positive breast cancer. Rates of pathologic complete response (pCR) did not differ between the two groups. Here, we present the survival outcomes from PREDIX HER2 and investigate metabolic response and tumor-infiltrating lymphocytes (TIL) as prognostic factors.

Patients and Methods:
In total, 202 patients with HER2-positive breast cancer were enrolled and 197 patients received six cycles of either THP or T-DM1. Secondary endpoints included event-free survival (EFS), recurrence-free survival (RFS), and overall survival (OS). Assessment with PET/CT was performed at baseline, after two and six treatment cycles. TILs were assessed manually at baseline biopsies, while image-based evaluation of TILs [digital TILs (DTIL)] was performed in digitized full-face sections.

Results:
After a median follow-up of 5.21 years, there was no difference between the two treatment groups in terms of EFS [HR = 1.26; 95% confidence interval (CI), 0.54–2.91], RFS (HR = 0.69; 95% CI, 0.24–1.93), or OS (HR = 0.52; 95% CI, 0.09–2.82). Higher SUVmax at cycle 2 (C2) predicted lower pCR (ORadj = 0.65; 95% CI, 0.48–0.87; P = 0.005) and worse EFS (HRadj = 1.27; 95% CI, 1.12–1.41; P &lt; 0.001). Baseline TILs and DTILs provided additional prognostic information to clinical parameters and C2 SUVmax.

Conclusions:
Long-term outcomes following neoadjuvant T-DM1 were similar to neoadjuvant THP. SUVmax after two cycles of neoadjuvant therapy for HER2-positive breast cancer may be an independent predictor of both short- and long-term outcomes. Combined assessment with TILs may facilitate early selection of poor responders for alternative treatment strategies.
Neglected from Societal Narratives and Minoritised
Authors: Chong Shao Yuan 
Published: November 2022

Abstract
This study explores the experiences of Taiwanese, Hong Konger, Malaysian, Singaporean, and Vietnamese community members as invisible Asian communities in Canada before and after covid-19. Ten interviewees participated online in semi-structured interviews, and results showed that minoritised Asian communities had a different experience from hegemonic ‘Asian’ community members in Canada because of their ethnocultural identities. Society’s attempts to homogenise the experience of ‘Asians’ has rendered the interviewees’ ethnocultural experience invisible in Canadian society. These experiences stirred polarising sentiments among interviewees towards their ethnocultural identity. As covid-19 hit, daily anxieties surrounding both the pandemic and ethnic-related attacks came to the fore of minoritised Asian community members’ concerns. Community members have been ambivalent about the impact of organised solidarity movements against anti-Asian racism. Given the findings from this study, researchers should consider disaggregating broad categories like the ‘Asian’ category for future research as well as policymaking.
REVISITING THE TAXONOMY OF TARENNA FLAVA ALSTON (RUBIACEAE: IXOROIDEAE)
Authors: NAIR MAYA SUKUMARAN , KONICKAL MAMBETTA PRABHUKUMAR  , SUNILKUMAR TRIVIKRAMAN PILLAI  , TARUN CHHABRA  
Published: November 2022

The present paper discusses the identity and distribution of Tarenna flava Alston (Rubiaceae: Ixoroideae) in India. Detailed description with colour photographs are provided along with morphological comparison of the allied species Tarenna asiatica (L.) Kuntze ex K. Schum. Here we also designated the lectotypes for the names Tarenna flava and Stylocoryna webera A. Rich var. montana Thwaites.