bluuebunny/crossref_metadata_2025_split huggingface dataset:
049 Factors Associated with Premature Ejaculation Might Influence the Female Sexual Function
Authors: Gao J. , Zhang Y. , Li H. , Gao P. , Zhang X. 
Published: May 2022

ABSTRACT

Introduction
Premature ejaculation (PE) is a multifactorial disease with complicated etiology, and has detrimental effects on the female partners’ sexual function. However, our country are lack of studies on the relationship between the factors related to PE and female sexual dysfunction (FSD) presently.

Objective
To investigate factors associated with premature ejaculation which might influence the female sexual function

Methods
From January 2018 to January 2019, an observational and cross-sectional field survey was conducted in the first affiliated hospital of Anhui medical university in Anhui province of China. A total of 761 couples that met our criteria made up our study population. Subjects were divided into two groups, including group with PE complaint and group without PE complaint. The survey was conducted by a professional Andrology doctor through the face-to-face guidance. All subjects were required to complete a questionnaire, including demographic information (e.g, age, education level and employment status), duration of PE and medical and sexual histories (e.g, Intravaginal ejaculation latency time [IELT], sexual desire,sexual frequency per month). In addition, we also investigated men's characters, incidence of men's negative psychology burden and different attitude toward to PE problem. Female partner of the patient were also evaluated by the Chinese vision of female sexual function index (FSFI), which included six dimensions (sexual desire, arousal, lubrication, orgasm, satisfaction and pain).

Results
The A total of 761 couples’ information were collected in this study, including 445 couples with PE complaint and 316 without PE complaint. In PE complaint group, the mean ages of men in PE and without PE complaint were 6.29 ± 9.87 years and 34.26 ± 8.83 years. Female partners in group with PE complaint reported lower total and sub-domain scores of FSFI, and approximately 65% of them were diagnosed with FSD (vs. control group: 31.96%). Duration of PE more than 14 months, self-estimated IELT less than 2 minutes, negative attitude toward PE problem, and men's introversion character and depression were the risk factors of FSD in PE complaint group.

Conclusions
In summary, PE and related factors are closely related to FSD, which implied that the focus of treatment for PE should transmit from men to the both sides and intensely emphasize the combination between mental behavioral therapy combined and drug therapy.

Disclosure
Work supported by industry: no.
062 Basic Research to Determine Normal Levels of Androgens (Testosterone, Free Testosterone, DHEA-S) in Japanese Middle-Aged Women
Authors: Sekiguchi Y. , Kumamoto Y. , Nakamura R. , Minami K. , Fujii M. 
Published: May 2022

ABSTRACT

Introduction
We surveyed the age distribution (30-80s) of blood androgen levels (testosterone, free testosterone, DHEA-S) in healthy Japanese women at the testing center currently used by general clinicians measure by method for creating androgen reference values ​​of Japanese women. In addition, the major female hormones estradiol, the gonadotropins LH and FSH, and IGF-1, which reflected growth hormone were measured at the same time.

Objective & Methods
We collected the bloods of 160 healthy volunteer women who visited the Women's Clinic LUNA JAPAN, Sapporo Toho Hospital, and Caress Sapporo Clock Tower Memorial Hospital between Oct. 2020 and Feb.2021 and measured testosterone, free testosterone, DHEA-S, estradiol, LH, FSH and IGF-1. The measurement was outsourced to the Biochemical Blood Testing Department of LSI Medience Corporation, and the androgen level was collectively measured by the CLIA method. The survey was conducted with the approval of the medical corporation LEADING GIERLS Ethics Committee and with the written consent of all patients.

Results
The average age of volunteer women was 45, the median was 41, the maximum was 87, and the minimum was 20. The number distribution was 16 in their 20’s, 52 in their 30’s, 43 in their 40’s, 17 in their 50’s, 15 in their 60’s, 10 in their 70’s, and 7 in their 80’s.
Table 1 shows the mean ± standard deviation of testosterone, free testosterone, DHEA-S, LH, FSH, estradiol, and IGF-1 for each age group. (Table 1)

Conclusions
In this group, regarding male hormones, DHEA and free testosterone decreased with age. In addition, IGF-1 also decreased with age. On the other hand, with regard to testosterone, the level of decrease is smaller than those of the other two androgens. Regarding estradiol, it decreased rapidly after menopause, but it is maintained at 10 to 20 pg / ml even after menopause. Healthy middle-aged women in Japan may maintain the lowest levels of testosterone and estradiol by eating a diet rich in sex hormone-like flavonoids such as soy isoflavones. However, the sexual function of healthy middle-aged and elderly people in Japan is said to be lower in both men and women than in Europe and the United States, and further research is needed on the relationship between Japanese sex hormone levels and sexual function and culture.

Disclosure
Work supported by industry: no.
SETTLED PRACTICE IN STATUTORY INTERPRETATION
Authors: Bailey Diggory 
Published: May 2022

AbstractWhat use (if any) may be made of settled practice in statutory interpretation and what are the potential justifications for its use? Debate about the use of settled practice is often framed in terms of a tension between legal certainty, on the one hand, and legal correctness in giving effect to Parliament's will, on the other. That account presents a false choice. This article explores the use of settled practice and argues that it has a legitimate role to play in statutory interpretation and one that is consistent with the prevailing approach of the courts to statutory interpretation.
Analyzing the Ambiguity of the Remanent‐Magnetization Direction Separated Into Induced and Remanent Magnetic Sources
Authors: Gonzalez Shayane P. , Barbosa Valéria C. F. , Oliveira Vanderlei C. 
Published: May 2022

AbstractWe developed a new ambiguity analysis method to investigate the remanence of a uniformly magnetized source. We wrote the unit vector of the total‐magnetization direction as the weighted sum of the unit vectors of the induced‐ and remanent‐magnetization directions. The unit vectors of the induced‐ and remanent‐magnetization directions are weighted, respectively, by the ratio between the induced and total‐magnetization intensities (λ), and by the multiplication of λ by the Koenigsberger ratio . We obtained analytical estimators for and the remanent magnetic inclination Ir and declination Dr. We constructed a family of ambiguity curves of , , and for a fixed total‐magnetization direction and for λ value. We estimated the total magnetic inclination It and declination Dt via the equivalent‐layer technique constrained by an all‐positive magnetic‐moment distribution. We also used some total‐magnetization directions associated with prespecified data‐residual errors. We performed a systematic search for both It and Dt to obtain a discrete data‐residual map on the plane It × Dt. We picked some It and Dt from the data‐residual map associated with a percent of data‐residual error and created some families of ambiguity curves of Ir, Dr, and λ versus . These ambiguity curves are quickly built up because we inverted the data only once. Tests with synthetic and field data from the Goiás Alkaline Province, Brazil, illustrated a wider perspective of the relationships between the remanent‐magnetization direction and for different data‐residual errors.
Three Types of Typhoon‐Induced Upwellings Enhance Coastal Algal Blooms: A Case Study
Authors: Li Yuxuan , Yang Dezhou , Xu Lingjing , Gao Guandong , He Zhiwei , Cui Xuan , Jiang Wenxin , Feng Xingru , Yin Baoshu 
Published: May 2022

AbstractSatellite data show that typhoon Chan‐hom did trigger an algal bloom several days after passing by the East China Sea. To investigate dynamic connections between this enhanced chlorophyll‐a and phosphate‐rich Kuroshio subsurface water (KSSW), we set up a fine‐resolution coupled physical‐biological model, which effectively reproduced the oceanic conditions during this typhoon. Furthermore, we released a passive tracer along a zonal transect northeast of Taiwan. The modeled surface tracer variations along the coast of Zhejiang agreed very well with satellite data and chlorophyll‐a changes in the biological model. The lowest structural similarity index between chlorophyll‐a and KSSW was 0.77. Model results along a coastal section imply that typhoon Chan‐hom induced additional upwellings and enhanced vertical mixing, leading to more KSSW outcropping. Through horizontal dynamic diagnostic and vertical velocity decomposition, we distinguished three types of dynamical mechanisms for the upward motions. At first, the linear wind Ekman effect existed around the coastal areas and led to intense Ekman pumping. Second, a pronounced nonlinear effect led to upwellings, and spectrum analysis revealed that this nonlinearity consisted of high‐frequency near‐inertial waves and low‐frequency coastal shelf waves. At last, an eddy field remained after the typhoon, continuously supplying nutrients upward to the surface layer by eddy‐induced Ekman pumping. This study reveals that these mechanisms may be general on the continental shelf, where typhoons can pump phosphate‐rich bottom water into the upper layer and enhance primary productivity there. The results also prove typhoon‐induced nonlinear wave motions on the continental shelf contribute to the outcrop of nutrients.
Magnons and magnetic fluctuations in atomically thin MnBi2Te4
Authors: Lujan David , Choe Jeongheon , Rodriguez-Vega Martin , Ye Zhipeng , Leonardo Aritz , Nunley T. Nathan , Chang Liang-Juan , Lee Shang-Fan , Yan Jiaqiang , Fiete Gregory A. , He Rui , Li Xiaoqin 
Published: May 2022

AbstractElectron band topology is combined with intrinsic magnetic orders in MnBi2Te4, leading to novel quantum phases. Here we investigate collective spin excitations (i.e. magnons) and spin fluctuations in atomically thin MnBi2Te4 flakes using Raman spectroscopy. In a two-septuple layer with non-trivial topology, magnon characteristics evolve as an external magnetic field tunes the ground state through three ordered phases: antiferromagnet, canted antiferromagnet, and ferromagnet. The Raman selection rules are determined by both the crystal symmetry and magnetic order while the magnon energy is determined by different interaction terms. Using non-interacting spin-wave theory, we extract the spin-wave gap at zero magnetic field, an anisotropy energy, and interlayer exchange in bilayers. We also find magnetic fluctuations increase with reduced thickness, which may contribute to a less robust magnetic order in single layers.
Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer
Authors: Pereira Patrícia M. R. , Mandleywala Komal , Monette Sébastien , Lumish Melissa , Tully Kathryn M. , Panikar Sandeep Surendra , Cornejo Mike , Mauguen Audrey , Ragupathi Ashwin , Keltee Nai C. , Mattar Marissa , Janjigian Yelena Y. , Lewis Jason S. 
Published: May 2022

AbstractResistance mechanisms and heterogeneity in HER2-positive gastric cancers (GC) limit Trastuzumab benefit in 32% of patients, and other targeted therapies have failed in clinical trials. Using patient samples, patient-derived xenografts (PDXs), partially humanized biological models, and HER2-targeted imaging technologies we demonstrate the role of caveolin-1 (CAV1) as a complementary biomarker in GC selection for Trastuzumab therapy. In retrospective analyses of samples from patients enrolled on Trastuzumab trials, the CAV1-high profile associates with low membrane HER2 density and low patient survival. We show a negative correlation between CAV1 tumoral protein levels – a major protein of cholesterol-rich membrane domains – and Trastuzumab-drug conjugate TDM1 tumor uptake. Finally, CAV1 depletion using knockdown or pharmacologic approaches (statins) increases antibody drug efficacy in tumors with incomplete HER2 membranous reactivity. In support of these findings, background statin use in patients associates with enhanced antibody efficacy. Together, this work provides preclinical justification and clinical evidence that require prospective investigation of antibody drugs combined with statins to delay drug resistance in tumors.
Modulating the evolutionary trajectory of tolerance using antibiotics with different metabolic dependencies
Authors: Zheng Erica J. , Andrews Ian W. , Grote Alexandra T. , Manson Abigail L. , Alcantar Miguel A. , Earl Ashlee M. , Collins James J. 
Published: May 2022

AbstractAntibiotic tolerance, or the ability of bacteria to survive antibiotic treatment in the absence of genetic resistance, has been linked to chronic and recurrent infections. Tolerant cells are often characterized by a low metabolic state, against which most clinically used antibiotics are ineffective. Here, we show that tolerance readily evolves against antibiotics that are strongly dependent on bacterial metabolism, but does not arise against antibiotics whose efficacy is only minimally affected by metabolic state. We identify a mechanism of tolerance evolution in E. coli involving deletion of the sodium-proton antiporter gene nhaA, which results in downregulated metabolism and upregulated stress responses. Additionally, we find that cycling of antibiotics with different metabolic dependencies interrupts evolution of tolerance in vitro, increasing the lifetime of treatment efficacy. Our work highlights the potential for limiting the occurrence and extent of tolerance by accounting for antibiotic dependencies on bacterial metabolism.
Integrated assessment of CO2-ECBM potential in Jharia Coalfield, India
Authors: Asif Mohammad , Wang Lei , Panigrahi D. C. , Ojha Keka , Hazlett Randy 
Published: May 2022

AbstractCoalbed methane (CBM) production is effectively achieved by utilizing two processes, viz. primary and secondary recovery. In this paper, the primary recovery of CBM was studied using the adsorption isotherm while CO2-ECBM process for the secondary recovery was simulated with realistic parameters. The adsorption isotherm for CH4 was drawn up to the pressure of 1200 psi for four coal samples and Langmuir isotherm curves for both CH4 and CO2 was measured for one sample up to 2000 psi. The adsorption isotherm of four samples was further utilized for finding the primary recovery factor of methane, showing that the average primary recovery is ~ 54% with the highest recovery factor of ~ 76% for one sample. Hence, CO2-ECBM process could be further implemented to enhance gas recovery. Then, a 3D heterogeneous coalbed model at a depth of 3219 ft was constructed using the COMET3 simulator to demonstrate the potential of CO2-ECBM recovery technique. A concept of break-even time was introduced in this study for the comprehension of CO2-ECBM process. It is found that coalbed reservoirs may opt to implement this technology with economically sound recovery.
Performance and milk quality parameters of Jersey crossbreds in low-input dairy systems
Authors: Ormston Sabrina , Davis Hannah , Butler Gillian , Chatzidimitriou Eleni , Gordon Alan W. , Theodoridou Katerina , Huws Sharon , Yan Tianhai , Leifert Carlo , Stergiadis Sokratis 
Published: May 2022

AbstractPrevious work has demonstrated some benefit from alternative breeds in low-input dairying, although there has been no systematic analysis of the simultaneous effect of Jersey crossbreeding on productivity, health, fertility parameters or milk nutritional quality. This work aimed to understand the effects of, and interactions/interrelations between, dairy cow genotypes (Holstein-Friesian (HF), Holstein-Friesian × Jersey crossbreds (HF × J)) and season (spring, summer, autumn) on milk yield; basic composition; feed efficiency, health, and fertility parameters; and milk fatty acid (FA) profiles. Milk samples (n = 219) and breed/diet data were collected from 74 cows in four UK low-input dairy farms between March and October 2012. HF × J cows produced milk with more fat (+ 3.2 g/kg milk), protein (+ 2.9 g/kg milk) and casein (+ 2.7 g/kg milk); and showed higher feed, fat, and protein efficiency (expressed as milk, fat and protein outputs per kg DMI) than HF cows. Milk from HF × J cows contained more C4:0 (+ 2.6 g/kg FA), C6:0 (+ 1.9 g/kg FA), C8:0 (+ 1.3 g/kg FA), C10:0 (+ 3.0 g/kg FA), C12:0 (+ 3.7 g/kg FA), C14:0 (+ 4.6 g/kg FA) and saturated FA (SFA; + 27.3 g/kg milk) and less monounsaturated FA (MUFA; -23.7 g/kg milk) and polyunsaturated FA (− 22.3 g/kg milk). There was no significant difference for most health and fertility parameters, but HF × J cows had shorter calving interval (by 39 days). The superior feed, fat and protein efficiency of HF × J cows, as well as shorter calving interval can be considered beneficial for the financial sustainability of low-input dairy farms; and using such alternative breeds in crossbreeding schemes may be recommended. Although statistically significant, it is difficult to determine if differences observed between HF and HF × J cows in fat composition are likely to impact human health, considering average population dairy fat intakes and the relatively small difference. Thus, the HF × J cow could be used in low-input dairying to improve efficiency and productivity without impacting milk nutritional properties.
Exploring influencing factors of chronic obstructive pulmonary disease based on elastic net and Bayesian network
Authors: Quan Dichen , Ren Jiahui , Ren Hao , Linghu Liqin , Wang Xuchun , Li Meichen , Qiao Yuchao , Ren Zeping , Qiu Lixia 
Published: May 2022

AbstractThis study aimed to construct Bayesian networks (BNs) to analyze the network relationships between COPD and its influencing factors, and the strength of each factor's influence on COPD was reflected through network reasoning. Elastic Net and Max-Min Hill-Climbing (MMHC) algorithm were adopted to screen the variables on the surveillance data of COPD among residents in Shanxi Province, China from 2014 to 2015, and construct BNs respectively. 10 variables finally entered the model after screening by Elastic Net. The BNs constructed by MMHC showed that smoking status, household air pollution, family history, cough, air hunger or dyspnea were directly related to COPD, and Gender was indirectly linked to COPD through smoking status. Moreover, smoking status, household air pollution and family history were the parent nodes of COPD, and cough, air hunger or dyspnea represented the child nodes of COPD. In other words, smoking status, household air pollution and family history were related to the occurrence of COPD, and COPD would make patients’ cough, air hunger or dyspnea worse. Generally speaking, BNs could reveal the complex network linkages between COPD and its relevant factors well, making it more convenient to carry out targeted prevention and control of COPD.
Left atrium phasic impairments in paroxysmal atrial fibrillation patients assessed by cardiovascular magnetic resonance feature tracking
Authors: Mojica-Pisciotti Mary Luz , Panovský Roman , Masárová Lucia , Pešl Martin , Stárek Zdeněk , Holeček Tomáš , Feitová Věra , Opatřil Lukáš , Doležalová Katarína , Kincl Vladimír 
Published: May 2022

AbstractAtrial fibrillation (AF) is an abnormal and irregular heartbeat caused by uncoordinated electrical impulses in the left atrium (LA), which could induce lasting changes in the heart tissue or could be a consequence of underlying cardiac disease. This study aimed to assess the left atrial phasic function and deformation in paroxysmal AF (PAF) patients—who had not received radiofrequency ablation and had no signs of permanent AF—using the cardiovascular magnetic resonance (CMR) feature-tracking (FT) technique. Fifty subjects (27 PAF patients and 23 controls) were included and examined with CMR. Their LA volume, LA function, LA longitudinal strain (LS) and LA strain rate were assessed in the LA reservoir, conduit, and contractile phases. PAF patients exhibited higher LA volumes than controls, while their LA emptying fraction and LA LS was significantly lower in all three phases. In contrast, the corresponding emptying volumes (total, passive and active) were similar in both groups. The LA volumetric rates from CMR-derived volume curves differed significantly in PAF patients vs controls in the reservoir and contractile phases. In contrast, the equivalent LV volumetric rates were similar. This study suggests that assessing the LA phasic function could offer insight into early LA impairments for PAF patients.
Estimating and explaining cross-country variation in the effectiveness of non-pharmaceutical interventions during COVID-19
Authors: Banholzer Nicolas , Feuerriegel Stefan , Vach Werner 
Published: May 2022

AbstractTo control the COVID-19 pandemic, countries around the world have implemented non-pharmaceutical interventions (NPIs), such as school closures or stay-at-home orders. Previous work has estimated the effectiveness of NPIs, yet without examining variation in NPI effectiveness across countries. Based on data from the first epidemic wave of$$n=40$$n=40countries, we estimate country-specific differences in the effectiveness of NPIs via a semi-mechanistic Bayesian hierarchical model. Our estimates reveal substantial variation between countries, indicating that NPIs have been more effective in some countries (e. g. Switzerland, New Zealand, and Iceland) as compared to others (e. g. Singapore, South Africa, and France). We then explain differences in the effectiveness of NPIs through 12 country characteristics (e. g. population age, urbanization, employment, etc.). A positive association with country-specific effectiveness of NPIs was found for government effectiveness, gross domestic product (GDP) per capita, population ages 65+, and health expenditures. Conversely, a negative association with effectiveness of NPIs was found for the share of informal employment, average household size and population density. Overall, the wealth and demographic structure of a country can explain variation in the effectiveness of NPIs.
Environmental transfer parameters of strontium for soil to cow milk pathway for tropical monsoonal climatic region of the Indian subcontinent
Authors: Ujwal P. , Yashodhara I. , Sudeep Kumara K. , Ravi P. M. , Karunakara N. 
Published: May 2022

AbstractThe radionuclide transfer between compartments is commonly described by transfer parameters representing the ratio of concentrations of an element in two compartments for equilibrium conditions. This is a comprehensive study on the soil-to-grass transfer factor (Fv) and grass-to-cow milk transfer coefficient (Fm) for stable strontium (Sr) for soil-grass (pasture)-cow (Bos taurus) milk environmental pathway under field conditions for a high rainfall tropical monsoonal climatic region of the Indian subcontinent. The study was conducted in the vicinity of the Kaiga nuclear power plant (NPP), situated ~ 58 km inland of the West Coast of the Indian subcontinent. A grass field was developed exclusively for this study, and two cows of the native breed were raised to graze on it. The soil, grass, and milk were analyzed to evaluate the Fv and the Fm values for the stable Sr. For comparison, several pasture lands and the cows raised by the villagers and a dairy farm were also studied. The Fv values were in the range 0.18—8.6, the geometric mean (GM) being 1.8. The correlations of Fv values with a range of physicochemical parameters are presented. The GM values for Fm were 2.2 × 10–3 d L-1 and 7.2 × 10–3 d L-1 for the two cows raised for this study, 2.6 × 10–3 d L-1 for those raised by the villagers, and 4.2 × 10–3 d L-1 for the dairy farm. The site-specific Fm value for the region was determined as 3.2 × 10–3 d L-1. The concentration ratio (CR), defined as the ratio of Sr concentration in milk to that in feed under equilibrium conditions, exhibited less variability (1.8 × 10–2—5.4 × 10–2) among the three categories of cows.