bluuebunny/crossref_metadata_2025_split huggingface dataset:
TCA-PEKS: Trusted Certificateless Authentication Public-key Encryption with Keyword Search scheme in Cloud Storage
Authors: Han Mu , Xu Puyi , Xu Lei , Xu Chungen 
Published: June 2022

Abstract
Public key encryption with keyword search (PEKS) technology achieves accurate ciphertext retrieval while protecting data privacy. However, curious or malicious semi-trusted cloud servers can cause privacy breaches, which bring a trusted problem of ciphertext management and searching. To address this problem, we present trusted certificateless authentication public-key encryption with keyword search scheme in cloud storage(TCA-PEKS), which ensuring trusted retrieval, simultaneously resolve the problems of key escrow and certificate management that exists in PEKS. In the scheme, the security of ciphertext storage and verification is strengthened based on blockchain non-tampering feature, which can assist users to verify the correctness of the file. Especially, we construct an open and transparent smart contract to limit the malicious behavior of cloud servers, in which the user’s complete private key splits the secret value and the partial private key, further guarantees the correctness of the retrieval process. Finally, the scheme is proved to satisfy ciphertext and trapdoor indistinguishability under the random oracle model, and the performance evaluation results show that the scheme is highly efficient.
Technical and sustainable goal-based assessment of combined floating solar PV systems with hydroelectric power station for cost-effective low-carbon clean energy generation
Authors: Singh Nimesh Kumar , Goswami Anik , Sadhu Pradip Kumar 
Published: June 2022

Abstract
The simultaneous escalation in energy consumption and greenhouse gases (GHG) in the environment drives power generation to pursue a more sustainable path. Solar photovoltaic (PV) is one of the technologies that has been identified as a possible source of clean, green and affordable energy in the future. The vast land area occupied by solar PV plants to generate electricity suggests that large PV facilities be built on the water surface which will not only save land but also increase efficiency and power output. Despite the remarkable geophysical conditions of India, the evaluation of floating solar photovoltaic (FSPV) power plants revealed little involvement in this technology. The objective of this research is to offer a comprehensive technical and sustainable goal-based analysis to provide an efficient hybrid hydel-FSPV system. In this paper, an assessment of a 96 MW power plant is done to show the economic and ecological benefits of FSPV. A comparison of land-based photovoltaic (LBPV), FSPV and hybrid hydel-FSPV is done to check the cost-efficiency and sustainability. The result indicates that the FSPV produces 81.39 GWh of excess generation compared to LBPV. The energy yield of FSPV is 2.4% more than LBPV. The total water saved by FSPV is 69.4 mcm. The equivalent carbon reduction by the FSPV plant is 123,454.53 tCO2. The levelized cost of energy generation is 3.23 $/W, which is 2.3% less than the current price of electricity. The FSPV can help in achieving sustainable development goals along with the protection of the ecological system.
Mitochondrial uncoupling protein 2 (UCP2) gene polymorphism -866 G/A in the promoter region is associated with Type 2 Diabetes Mellitus among Kashmiri population of Northern India
Authors: Din Inshah , Majid Sabhiya , Rashid Fouzia , Wani Mumtaz Din , Qadir Jasiya , Wani Hilal , Fareed Mohd 
Published: June 2022

Abstract
Objective: The objective of the study was to evaluate the association of UCP2 gene polymorphism -866 G/A and its expression with diabetic predisposition in North Indian population. Methods: The study involved 850 subjects, including 425 each T2DM and control subjects. The serum metabolic and clinical parameters were estimated using standard protocols. The genotyping for determining UCP2 gene polymorphism was performed by the PCR-RFLP while the expression was measured by real-time quantitative PCR. Results: The genotypic and allelic frequencies showed a significant difference in cases when compared to controls (p<0.05). The diabetic patients had a 4.2 fold decrease in UCP2 gene expression. The expression was 29.8 and 8.4 fold lower in diabetic patients with homozygous (AA) and heterozygous (GA) mutation at -866 locus of UCP2 nucleotide sequence respectively. When categorized according to age and BMI, the T2DM subjects with age ≥50 and BMI ≥25 had 5.53 and 8.2-fold decrease in UCP2 expression. The diabetic subjects with homozygous and heterozygous mutation demonstrated a pathological increase in serum metabolic and clinical parameters which again corroborated with UCP2 gene expression indicating a strong association between the two. Intriguingly, we did not find any association between -866 G/A polymorphism of UCP2 with serum insulin levels. Conclusion: The association of -866 G/A SNP of UCP2 gene with its expression in diabetic patients appears to be an important genetic determinant in the progression of T2DM. Moreover, Age ≥50 years and BMI ≥25 could be considered as a risk factor for developing T2DM in the studied population.
A qualitative study of the Tongan cultural and masculine factors that support the minimisation and prevention of gambling harm in New Zealand
Authors: Fehoko Edmond , Bellringer Maria 
Published: June 2022

Abstract
BackgroundPacific peoples continue to be more at risk of gambling harm than the general population, despite increasing public health efforts and treatment service provisions introduced to address this social and health issue. In looking at why this is so, our first concern was to ask why the delivery of the prevailing gambling-focussed programmes was not influencing Pacific gambling behaviours. In seeking to answer this question, it was important to explore ethnic-Pacific-specific factors of gambling-harm prevention and minimisation.MethodsThe research design was interpretivist/constructivist and phenomenological, applied through the lens of a Tongan worldview. Participants comprised of Tongan male elders and youth. Recruitment of participants was through snowball sampling from churches and kava-drinking circles. A total of 28 elders and 18 youth participated through focus group talanoa and individual talanoa. This study employed the descriptive thematic analysis drawing on components of the Interpretative Phenomenological Analysis approach.ResultsParticipants were not aware of any policy document or problem-gambling preventative programmes. Four key themes were raised, which include raising the awareness of existing gambling-harm treatment providers, the church influence in addressing gambling harm, community-based strategies, and cultural-based approaches. ConclusionsThis study proposes several recommendations and calls for further studies in addressing the prevention and minimisation of gambling harm amongst the Tongan community in New Zealand.
Optimal Resource Allocation For Efficient Task Scheduling leverged With Optimal Cluster Head Selection For Smart Argriculture
Authors: SALOTAGI SHREEKANT , MALLAPUR JAYASHREE D 
Published: June 2022

Abstract
Agriculture is dwindling all across the world, which has an impact on ecosystem production capacity. There is an urgent need to resolve the issue in the domain so that it may reclaim its vitality and resume its upward trajectory. A revolutionary two-tier approach is designed in this study endeavour to aid farmers in continual field monitoring. In this research work, a novel smart agriculture system has been developed with IoT-Cloud Computing for efficient monitoring of the agriculture farm. The proposed model is divided into two parts: (a) the land-subsystem and (b) the cloud user-subsystem. The agricultural area has been outfitted with several IoT sensor nodes for monitoring "soil PH level, water level, temperature, humidity, moisture, weeding, nutrition, variable spraying, salinity, and rainfall”. These sensors are grouped together, and the Cluster Head (CH) connects the clustered nodes to the Base Station (BS). The CH is chosen using the newly proposed Multi-Objective Modified Emperor Penguin Optimization (MEPO) approach, which takes into account many factors such as remaining energy, distance, latency, and QoS. The land-based data is continually stored in the cloud server through the gateway. The cloud sub-system, on the other hand, encompasses the farmers, Physical Machine (PM), and Virtual Machine (VM). The PM assigns a certain VM to process the required work based on the request received from the farmers. Furthermore, the Lionized Golden Eagle optimization (LGEO) based 6-fold goal model is projected for optimum task allocation onto the VM, with a focus on power consumption, migration cost, memory utilization, response time and server load and execution time. The proposed model, as a whole, becomes suited for end-to-end farm monitoring.
Complete genome analysis of multi drug resistant Klebsiella aerogenes for detection of antibiotic resistance genes in bacterial isolates prevalent in agricultural soils
Authors: Mann Avantika , Rana J. S. , Gaurav Sharma , Nehra Kiran 
Published: June 2022

Abstract
Due to the prolonged use of antibiotics in agriculture, antibiotic resistance has become a major concern. Hence, the present study involved evaluation of the presence of antibiotic resistance genes in the bacterial isolates prevalent in agricultural soils of Haryana, India. Bacteria were isolated from agricultural soils collected from different districts of the state, and all the isolates were subjected to antibiotic resistance screening tests against four commonly used antibiotics viz. penicillin, tetracycline, streptomycin and erythromycin. On the basis of high resistance activity, six bacterial isolates were selected for molecular studies, and the isolate exhibiting maximum resistance was selected for whole genome sequencing (WGS). Based upon WGS analysis, resistance genes were identified in the selected isolate, out of which six genes were selected for wet lab analysis. These six genes when subjected to amplification studies in the other five identified bacteria, revealed their presence in some of these isolates as well. Apart from the 28 identified genes, “blaTEM” gene, was also identified using amplification studies in Klebsiella aerogenes. To the best of our knowledge blaTEM has not yet been reported in Klebsiella aerogenes. The presence of several multi-drug-resistance (MDR) genes has been confirmed in the bacterial microflora inhabiting the collected soils.
Validation of the Functional Vision Evaluation for Children (FVEC) Battery
Authors: Lopes Marcia Caires Bestileiro , Santos Marcela Aparecida , Nakanami Célia Regina , Costa Marcelo Fernandes 
Published: June 2022

Abstract
Background
we validated the recently developed Functional Vision Evaluation for Children (FVEC) Battery, which quantitatively measures major eye and visual function for rehabilitation.
Methods
The protocol for this test comprises 12 items involving unique abilities of the functional vision evaluated for 3 subsequent periods. Validation procedure includes analysis of difficulty of the examiner performance, the reliability and symmetry evaluation of the battery items and the prediction of the children in low vision category on a 0-100 ranking scale of visual behaviors. Factor analysis evaluates the contribution of the items to functions of Ventral and Dorsal visual streams.
Results
consistency was similar between the 3 examiners and the reliability intra-subjects was also significantly high for examiner 1 (α = 0.86), examiner 2 (α = 0.85) and examiner 3 (α = 0.87). A Factor Analysis confirms that we arranged our data in two major factors expressing Ventral and Dorsal-related visual functions.
Conclusions
we validate the FVEC battery with high robustness, internal consistency and an outcome regarding the functional performances for the visual Ventral and Dorsal-related functions.
Securing Things: A Novel CRO Applicable in PUF and Recycled IC Detection
Authors: Ram Saswat Kumar , Sahoo Sauvagya Ranjan , Das Banee Bandana , Mahapatra Kamalakanta , Mohanty Saraju P 
Published: June 2022

Abstract
Ring Oscillator (RO) is widely used to address different hardware security issues. For example, using RO-based physical unclonable function (PUF) generates a secure and reliable key for the cryptographic application, RO-based aging sensor for efficient detection of recycled ICs. This paper uses a conventional CMOS inverter with two voltage control signals to design a configurable RO (CRO). With its control signal, the proposed CRO can perform both, i.e., accelerate or lower the impact of aging on the oscillation frequency. Due to this vital feature of the proposed CRO, it can be used in PUF and RO-based sensors. The performance of the proposed modified architecture, i.e., CRO PUF and CRO sensor, is evaluated in 90 nm CMOS technology. The aging tolerant feature of the proposed CRO enhances the reliability of CRO PUF. Similarly, the aging acceleration property of CRO improves the rate of detection of recycled ICs. Finally, the proposed architecture is also area and power-efficient compared to conventional architectures.
Comparing the anterior chamber depth of East Asian and non-East Asian eyes
Authors: Dasgupta Amrita , Ong Keith 
Published: June 2022

Abstract
Purpose
To compare the anterior chamber depth between East Asian and non-East Asian eyes.

Method
A retrospective cohort study was conducted on a sample of 4276 eyes. Data spanning 7 years was obtained from a private ophthalmology practice in Sydney. Patient files were stratified into three age groups (<40-years, 40-60 years, >60-years) and then further sub-divided by ethnicity (East-Asian and non-East-Asian). Statistical analysis was conducted using IBM SPSS Statistics-26.

Results
The results demonstrate that age, sex, and ethnicity all impact the ACD. The mean ACD in East-Asians (3.13±0.36mm) is significantly (p<0.001) lower than that of non-East-Asians (3.21±0.35mm). The mean ACD in females (3.10±0.36mm) is significantly (p<0.001) lower than that of males (3.21±0.34mm). Mean ACD also declines with age; the mean ACD for the <40-years, 40-60 years and >60 years are 3.49±0.29mm, 3.13±0.34mm and 3.08±0.35mm respectively. The trends in sex and age were also observed when the data was analysed by ethnicity.

Conclusion
Eyes of East-Asian ethnicity have shallower ACD in all age groups. The female gender also had shallower ACD in both East-Asian and non-East-Asian eyes.
The efficacy of transarterial chemoembolization in downgrading unresectable hepatocellular carcinoma to curative therapy: a predictive regression model
Authors: Lin Haomin , Luo Bin , Peng Fangyi , Fang Cheng , Gan Yu , Yang Xiaoli , Li Bo , Li Yaling , Su Song 
Published: June 2022

Abstract
Background/Objective: Patients with hepatocellular carcinoma (HCC) outside Milan criteria (MC) may be candidates for curative therapy after successful downstaging. We aimed to identify the predictors of successful downstaging of unresectable HCC in patient by transarterial chemoembolization (TACE) outside MC.Methods: We performed a retrospective study on patients with unresectable HCC outside MC who received downstaging with TACE. Clinical and laboratory variables were recorded. We identified 101 patients with unresectable HCC who underwent initial TACE, who formed the derivation set of this study. Thirty patients who treated by TACE with the same selection criteria served as an external validation set. We performed univariate and multivariate logistic regression analyses to identify variables associated with successful downstaging. Then we did the predictive model to predict the efficiency of TACE.Results: Of the 101 patients in the study, 26 patients (25.7%) were successfully downstaging and 75 patients (74.3%) failed downstaging. Multivariate analysis of factors to predict successful downstaging of HCC outside MC the number of tumor (P=0.01), portal vein tumor thrombosis (PVTT)(p＜0.01), the size of tumor (P=0.02), hepatitis B surface antigen (HBsAg) (P=0.01), α-fetoprotein (AFP) (P=0.02) as significant predictors of successful downstaging. Then we constructed the predictive model. The area under the ROC curve (AUROC) of the predictive equation was 0.90 (95% confidence interval, 0.83-0.95).Conclusions: We found in our study that the number and size of tumors, PVTT, HBsAg, and AFP are good predictors of successful downstaging of unresectable HCC in patients by TACE outside the MC.
Microstructural properties of white matter in the corpus callosum in neonates and children born preterm and full-term: Quantitative meta-analyses
Authors: Buyanova Irina , Lysenko Elena , Grischuk Denis , Afanasieva Victoria , Arsalidou Marie 
Published: June 2022

Abstract
Nearly 15 million infants are born preterm every year. Research shows that compared to their full-term peers, individuals born preterm are more likely to have lower academic scores and be less wealthy later in life. Some suggest that brain connectivity as measured by diffusion tensor imaging (DTI) may underly these results. Critically, these differences have not been substantiated quantitatively. We performed quantitative meta-analyses to evaluate overarching patterns from articles that reported DTI metrics from the corpus callosum (CC), the largest white matter structure in the brain, in neonates and children/adolescents who were born pre-term and full-term. The DTI literature was reviewed using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Two meta-analyses, considering publication bias and study heterogeneity, were performed onfractional anisotropy scores from the CC from eligible articles that scanned individuals at 39.9±1.1 weeks (i.e., neonates) and 14±4.13 years of age (i.e., children/adolescents). Meta-analyses for neonates and children/adolescents revealed no significant differences between those born preterm and full-term in the CC. Children/adolescents samples were characterized by significant publication bias and high interstudy heterogeneity, whereas the neonate samples were not. The findings challenge the current state of understanding of white matter microstructure in the CC related to preterm birth. Results highlight the need for further research to better understand the dynamics among factors that can influence neural development in preterm children.
Observation, radiotherapy, or radical prostatectomy for localized prostate cancer: Survival analysis in the United States
Authors: Jeong Chang Wook , Han Jang Hee , Herlemann Annika , Washington III Samuel , Lonergan Peter , Carroll Peter , Cooperberg Matthew 
Published: June 2022

Abstract
Background: Contemporary treatment strategies for localized prostate cancer (PCa) have been evolved over time. However, there is little data regarding survival outcomes based on initial treatment by risk group in this new era. This study aims to evaluate survival outcomes among men who underwent observation, radiotherapy, or radical prostatectomy for localized PCa using a population-based cohort.Methods: The Surveillance, Epidemiology, and End Results (SEER) prostate with watchful waiting dataset (2010-2016) was used. We included men diagnosed with localized PCa and clinical stage T1c-2cN0M0. Other inclusion criteria were age 50-79 years, prostate-specific antigen (PSA) ≤50ng/mL, and initial treatment with observation (active surveillance/watchful waiting), radiotherapy, or radical prostatectomy. PCa risk was assessed using the D’Amico classification. The primary endpoint was overall survival. Secondary endpoints included prostate cancer-specific survival. Inverse probability of treatment weighting (IPTW)-adjusted Cox proportional hazard regression and competing risk analysis were performed to assess outcomes.Results: After IPTW-adjusting, pseudo-population comprised 521,656 men (observation: 170,428, radiotherapy: 175,628, radical prostatectomy: 175,600) at a median 36.5-mon follow-up. Observation demonstrated the lowest 5-year overall survival rate (91.6%) after IPTW-adjusting in comparison to radiotherapy (92.4%) and radical prostatectomy (96.1%, p<.001). Men who underwent radical prostatectomy had the lowest cumulative prostate cancer-specific and all-cause mortality (p<.001). Compared to observation, radiotherapy (sub-distribution hazard ratio1 0.89, 95% CI 0.81-0.97, p=.012) and radical prostatectomy (sHR 0.46, 95%CI 0.41-0.52, p<.001) had a lower risk of prostate cancer-specific mortality in competing risk analysis after adjustment for all other factors and other-cause death.Conclusions: Intermediate-term mortality risk in men with localized PCa were lower with active treatments compared to observation - especially for intermediate- and high-risk disease. However, observation represents a safe management strategy in men within the low-risk group.
A Noval Prognostic Signature of the N7-Methylguanosine (m7G)-Related miRNA in Lung Adenocarcinoma Running title: Prognostic Signature of m7G Related miRNA in Lung Adenocarcinoma
Authors: Duan Han-ping , Yan Jian-hui , Nie Lin , Wang Ye , Xie Hui 
Published: June 2022

Abstract
Background: Lung adenocarcinoma (LUAD) is characterized by high morbidity and mortality rates and poor prognosis. N7-methylguanosine play an increasingly vital role in lung adenocarcinoma. However, the prognostic value of N7-methylguanosine related-miRNAs in lung adenocarcinoma remains unclear.Methods: In the study, the mRNA and miRNA expression profiles and corresponding clinical informations were downloaded from the public database. The prognostic signature was built using least absolute shrinkage and selection operator Cox analysis. The Kaplan-Meier method was used to compare survival outcomes between the high- and low-risk groups. Signatures for the development of lung adenocarcinoma were tested using univariate and multivariate Cox regression models. Single-sample gene set enrichment analysis was used to determine the immune cell infiltration score. First, we predicted METTL1 and WDR4 chemosensitivities based on a public pharmacogenomics database. The area under the receiver operating characteristic curve showed that the performance of signature in 1-,3-, and 5-year survival predictions were 0.68, 0.65, and 0.683, respectively. Results: We established a novel prognostic signature consisting of 9 N7-Methylguanosine related miRNAs using least absolute shrinkage and selection operator Cox analysis. Patients in the high-risk group had shorter survival times than those in the low-risk group did. The calibration curves at 1, 3, and 5-year also illustrate the high predictive power of the structure. Signature was corrected using the Toumor stage. The expression levels of METTL1 and WDR4 significantly correlated with the sensitivity of cancer cells to antitumor drugs.Conclusions: A novel signature constructed using 9 N7-methylguanosine related-miRNAs can be used for prognostic prediction.