bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of Human Parainfluenza Virus Type 3 and Respiratory Syncytial Virus Infections in the Time of Coronavirus Disease 2019: Findings From a Household Cohort in Maryland
Authors: Hetrich Marissa K , Oliva Jennifer , Wanionek Kimberli , Knoll Maria Deloria , Lamore Matthew , Esteban Ignacio , Veguilla Vic , Dawood Fatimah S , Karron Ruth A ,   for the SARS-CoV-2 Epidemiology And Response in Children Study Team, Council-DiBitetto Christine , Gatto Milena , Quesada Maria Garcia , Ghasri Tina , Gormley Amanda , Herbert Kristi , Jordan Maria , Loehr Karen , Morsell Jason , Na Yu Bin , Mateo Jocelyn San , Schappell Elizabeth , Smith Khadija , Weadon Cathleen , Williams-Soro Paula , Woods Suzanne 
Published: December 2022

AbstractBackgroundDuring the coronavirus disease 2019 (COVID-19) pandemic, human parainfluenza type 3 (HPIV-3) and respiratory syncytial virus (RSV) circulation increased as nonpharmaceutical interventions were relaxed. Using data from 175 households (n = 690 members) followed between November 2020 and October 2021, we characterized HPIV-3 and RSV epidemiology in children aged 0–4 years and their households.MethodsHouseholds with ≥1 child aged 0–4 years were enrolled; members collected weekly nasal swabs (NS) and additional NS with respiratory illnesses (RI). We tested NS from RI episodes in children aged 0–4 years for HPIV-3, RSV, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using reverse-transcriptase polymerase chain reaction (RT-PCR). Among children with HPIV-3 or RSV infection, we tested contemporaneous NS from household members. We compared incidence rates (IRs) of RI with each virus during epidemic periods and identified household primary cases (the earliest detected household infection), and associated community exposures.Results41 of 175 (23.4%) households had individuals with HPIV-3 (n = 45) or RSV (n = 46) infections. Among children aged 0–4 years, RI IRs /1000 person-weeks were 8.7 [6.0, 12.2] for HPIV-3, 7.6 [4.8, 11.4] for RSV, and 1.9 [1.0, 3.5] for SARS-CoV-2. Children aged 0-4 years accounted for 35 of 36 primary HPIV-3 or RSV cases. Children attending childcare or preschool had higher odds of primary infection (odds ratio, 10.81; 95% confidence interval, 3.14–37.23).ConclusionsAmong children aged 0–4 years, RI IRs for HPIV-3 and RSV infection were 4-fold higher than for SARS-CoV-2 during epidemic periods. HPIV-3 and RSV were almost exclusively introduced into households by young children.
Estimating reproductive costs in marine mammal bioenergetic models: a review of current knowledge and data availability
Authors: McHuron Elizabeth A , Adamczak Stephanie , Costa Daniel P , Booth Cormac 
Published: December 2022

Abstract
Reproductive costs represent a significant proportion of a mammalian female's energy budget. Estimates of reproductive costs are needed for understanding how alterations to energy budgets, such as those from environmental variation or human activities, impact maternal body condition, vital rates and population dynamics. Such questions are increasingly important for marine mammals, as many populations are faced with rapidly changing and increasingly disturbed environments. Here we review the different energetic costs that marine mammals incur during gestation and lactation and how those costs are typically estimated in bioenergetic models. We compiled data availability on key model parameters for each species across all six marine mammal taxonomic groups (mysticetes, odontocetes, pinnipeds, sirenians, mustelids and ursids). Pinnipeds were the best-represented group regarding data availability, including estimates of milk intake, milk composition, lactation duration, birth mass, body composition at birth and growth. There were still considerable data gaps, particularly for polar species, and good data were only available across all parameters in 45% of pinniped species. Cetaceans and sirenians were comparatively data-poor, with some species having little or no data for any parameters, particularly beaked whales. Even for species with moderate data coverage, many parameter estimates were tentative or based on indirect approaches, necessitating reevaluation of these estimates. We discuss mechanisms and factors that affect maternal energy investment or prey requirements during reproduction, such as prey supplementation by offspring, metabolic compensation, environmental conditions and maternal characteristics. Filling the existing data gaps highlighted in this review, particularly for parameters that are influential on bioenergetic model outputs, will help refine reproductive costs estimated from bioenergetic models and better address how and when energy imbalances are likely to affect marine mammal populations.
Seismic source mapping by surface wave time reversal: application to the great 2004 Sumatra earthquake
Authors: Sharma Dhakal Apsara , Molinari Irene , Boschi Lapo 
Published: December 2022

SUMMARY
Different approaches to map seismic rupture in space and time often lead to incoherent results for the same event. Building on earlier work by our team, we ‘time-reverse’ and ‘backpropagate’ seismic surface wave recordings to study the focusing of the time-reversed field at the seismic source. Currently used source-imaging methods relying on seismic recordings neglect the information carried by surface waves, and mostly focus on the P-wave arrival alone. Our new method combines seismic time reversal approach with a surface wave ray-tracing algorithm based on a generalized spherical-harmonic parametrization of surface wave phase velocity, accounting for azimuthal anisotropy. It is applied to surface wave signal filtered within narrow-frequency bands, so that the inherently 3-D problem of simulating surface wave propagation is separated into a suite of 2-D problems, each of relatively limited computational cost. We validate our method through a number of synthetic tests, then apply it to the great 2004 Sumatra–Andaman earthquake, characterized by the extremely large extent of the ruptured fault. Many studies have estimated its rupture characteristics from seismological data (e.g. Lomax, Ni et al., Guilbert et al., Ishii et al., Krüger & Ohrnberger, Jaffe et al.) and geodetic data (e.g. Banerjee et al., Catherine et al., Vigny et al., Hashimoto et al., Bletery et al.). Applying our technique to recordings from only 89 stations of the Global Seismographic Network (GSN) and bandpass filtering the corresponding surface wave signal around 80-to-120, 50-to-110 and 40-to-90 s, we reproduce the findings of earlier studies, including in particular the northward direction of rupture propagation, its approximate spatial extent and duration, and the locations of the areas where most energy appears to be released.
Holographic realization of the prime number quantum potential
Authors: Cassettari Donatella , Mussardo Giuseppe , Trombettoni Andrea 
Published: December 2022

Abstract
We report the experimental realization of the prime number quantum potential VN(x), defined as the potential entering the single-particle Schrödinger Hamiltonian with eigenvalues given by the first N prime numbers. Using computer-generated holography, we create light intensity profiles suitable to optically trap ultracold atoms in these potentials for different N values. As a further application, we also implement a potential whose spectrum is given by the lucky numbers, a sequence of integers generated by a different sieve than the familiar Eratosthenes’s sieve used for the primes. Our results pave the way toward the realization of quantum potentials with arbitrary sequences of integers as energy levels and show, in perspective, the possibility to set up quantum systems for arithmetic manipulations or mathematical tests involving prime numbers.
Regulatory T cells and systemic vasculitis
Authors: Mirouse Adrien , Cacoub Patrice , Saadoun David 
Published: December 2022

Purpose of the review
Emerging data suggest that regulatory T-cells (Treg) alterations play a major role in systemic vasculitis pathophysiology. We performed a systematic review of recent advances in the role of Treg and interleukin (IL)-10 in the pathogenesis and treatment of systemic vasculitis, including giant cell arteritis (GCA), Takayasu arteritis, Behçet's disease, antineutrophil cytoplasm antibodies (ANCA) associated vasculitis (AAV), and cryoglobulinemia associated vasculitis.

Recent findings
Emerging data suggest that Treg deficiencies are disease-specific, affecting distinct pathways in distinct vasculitides. Decreased peripheral blood frequencies of Treg are described in all vasculitis when compared to healthy donors. Altered Treg functions are reported in GCA, Takayasu arteritis, AAV, and Behçet's disease with different mechanisms proposed. Treatment with biologics, and sometimes other immunosuppressants, may restore Treg frequencies and/or immune activity with significant differences in active disease or disease in remission in several systemic vasculitis. IL-10 is elevated in GCA, AAV, cryoglobulinemia associated vasculitis. In Behçet's disease, IL-10 is decreased in peripheral blood and elevated in saliva. In Takayasu arteritis, IL-10 levels were essentially elevated in patients’ vessel wall. Several new therapeutic approaches targeting Treg and Il-10 (low dose IL-2, CAR Treg…) are developed to treat patients with systemic vasculitis.

Summary
Treg and IL-10 play a central role in the regulation of inflammation in vasculitis and new targeting approaches are emerging.
A Russian carol: impact and dependence on global equity markets during the Ukraine invasion
Authors: Ferrández-Serrano Victoria , Angosto-Fernández Pedro L. 
Published: December 2022

PurposeThe authors present a study of the short-term impact of the Russian–Ukrainian war on global equity returns. The study aims to show that the conflict was priced into markets and whether the intensity of the impact depends on economic factors, such as dependence on gas, or/and political factors, such as belonging to the former Soviet power circle.Design/methodology/approachUsing the event study and a sample of 77 capital markets, accounting for over 99% of global capitalisation, the authors apply a system of seemingly unrelated regressions to the daily returns of the indices, isolating the short-term effect on the markets and finally apply cross-sectional methods to help determine the size and variability of the impact.FindingsThe authors show that the impact is concentrated around day zero but is relevant in the days before and after. In addition, the authors show that being in the Soviet orbit and NATO simultaneously, as well as having high gas consumption and importing gas from Russia were key factors for investors.Originality/valueThis study is the first to try to discern whether the impact on stock markets caused by the war in Ukraine is due to purely economic factors, especially energy, or whether there is also a geopolitical component. Specifically, whether the countries closest to Russia are being more threatened by the fact that they are closer to Russia.
Indirect effects of personality on high‐intensity drinking: The role of drinking motives
Authors: Bachrach Rachel L. , Zhou Agnes , Kumar Lakshmi , Lyons Greta , Skrzynski Carillon J. , Creswell Kasey G. 
Published: December 2022

AbstractBackgroundResearchers have long been interested in identifying risk factors for binge drinking behavior (4+/5+ drinks/occasion for females/males), but many studies have demonstrated that a substantial proportion of young adults are drinking at levels far beyond (often 2 to 3 times) the standard binge threshold. The consumption of such large quantities of alcohol, typically referred to as high‐intensity drinking (HID), can cause severe alcohol‐related problems, such as blackouts, unintended sexual experiences, and death. This study is the first to investigate whether personality is indirectly associated with the likelihood of HID via drinking motives in a large (N = 999) sample of underage young adult drinkers. We hypothesized that trait neuroticism would be indirectly associated with the likelihood of HID via coping motives and that extraversion would be indirectly associated with the likelihood of HID via social and enhancement motives.MethodsTo investigate these hypotheses, we used two archival data sets that recruited current underage (18‐ to 20‐year‐old) adult drinkers residing in the United States from online panel services. Participants completed self‐report survey items assessing constructs of interest. To investigate the role of drinking motives in the association between personality and HID, both the direct and indirect effects were calculated via three path analyses.ResultsFindings revealed that neuroticism was partially indirectly associated with the likelihood of HID via coping motives (b = 0.02, SE = 0.004, p < 0.01). In addition, extraversion was indirectly associated with the likelihood of HID via social (b = 0.031, SE = 0.002, p < 0.01) and enhancement motives (b = 0.01, SE = 0.002, p = 0.01).ConclusionsThese findings are an initial step in examining the interplay among personality traits, drinking motives, and HID in underage drinkers and point to the need for longitudinal studies assessing these associations.
Annual Research Review: Stability of psychopathology: lessons learned from longitudinal population surveys
Authors: Oldehinkel Albertine J. , Ormel Johan 
Published: December 2022

BackgroundPsychopathology has been long recognized as a fluctuating process with various expressions over time, which can only be properly understood if we follow individuals and their social context from childhood up until adulthood. Longitudinal population‐based studies have yielded powerful data to analyze this process. However, the resulting publications have not been reflected upon with regard to (a) the homotypic and heterotypic stability of internalizing and externalizing problems and (b) how transactions between psychopathology and environmental factors shape its development.MethodsIn this narrative review, we primarily focused on population‐based studies that followed cohorts repeatedly from an early age (<18 years) onwards, across multiple stages of development, using statistical methods that permit inferences about within‐person bidirectional associations between internalizing and externalizing problems or psychopathology–environment transactions.ResultsThere is robust evidence that mental health problems in childhood or adolescence predict psychiatric problems later in development. In terms of the broadband domains internalizing and externalizing problems, homotypic stability greatly exceeds heterotypic stability and transitions from purely internalizing to purely externalizing problems or vice versa are rare. Homotypic rank‐order stabilities seem to increase over time. Findings regarding transactions with environmental factors are less robust, due to widely varying research topics and designs, and a scarcity of studies that separated between‐person differences from within‐person changes. In general, however, the literature shows little consistent evidence for substantial mutual prospective influences between psychopathology and environmental factors.ConclusionsLongitudinal surveys have strongly augmented insight into homotypic and heterotypic stability and change. Attempts to unravel the myriad of risk and protective factors that place individuals on particular pathways or deflect them from these pathways are still in a pioneering phase and have not yet generated robust findings. As a way forward, we propose to join forces and develop a common risk factor taxonomy.
Inhibition of the largemouth bass virus replication by piperine demonstrates potential application in aquaculture
Authors: Wang Mengmeng , Yang Bin , Ren Zongyi , Liu Jietao , Lu Chenwang , Jiang Haifeng , Ling Fei , Wang Gaoxue , Liu Tianqiang 
Published: December 2022

AbstractLargemouth bass virus (LMBV) is a systemic viral pathogen that can cause high mortality rates in cultivated largemouth bass. However, no treatment is currently approved. Therapeutic strategies against LMBV infection are urgently needed. In this study, we investigated the antiviral activity of piperine against LMBV in vitro and in vivo. In vitro antiviral activity assay showed that 210.28 μM piperine significantly decreased LMBV major capsid protein (MCP) gene expression in epithelioma papulosum cyprinid (EPC) cells by a maximum inhibitory rate of >95%. Piperine treatment inhibited LMBV replication in a dose‐dependent manner, with the half‐maximal activity (IC50) of 34.61 μM. Moreover, piperine significantly decreased the viral titers and cytopathic effects (CPE), contributing to the protection of infected cells. With regard to the steps of piperine affecting the life cycle of viruses, piperine had a direct inactivating effect on LMBV. During the virus adsorption phase, piperine prevented the adsorption of LMBV to EPC cells. Furthermore, piperine played an antiviral role mainly in the later stages of viral infection (4–8 h). To further evaluate the antiviral activity of piperine against LMBV in vivo, largemouth bass as a model organism was carried out in relevant experiments. Intraperitoneal injection of piperine (25 mg/kg) effectively improved the survival rate of LMBV‐infected largemouth bass by 20%. In addition, RT‐qPCR results of viral replication in liver, spleen, kidney, gill and swim bladder tissues showed that piperine significantly inhibited LMBV replication in vivo, thus protecting largemouth bass from LMBV‐induced death. Together, our results suggested that piperine is a therapeutic and preventative agent against LMBV infection.
Systematic review and meta‐analysis on the association between chronic low back pain and cognitive function
Authors: Pereira Nery Ellen C. H. , Rocha Nelson P. , Cruz Vitor T. , Silva Anabela G. 
Published: December 2022

AbstractThis study aimed to identify and assess the evidence on the association between idiopathic chronic low back pain (LBP) and cognitive function in individuals with LBP. A secondary aim was to explore whether changes in cognitive function are associated with pain characteristics and psychological factors (eg, catastrophizing and fear of movement). Eleven studies were included in this systematic review, and four meta‐analyses were conducted. Low to very low‐quality evidence suggests impaired cognitive function in individuals with LBP compared to asymptomatic controls for problem solving (k = 5; d = 0.33; CI = 0.16–0.50; z = 3.85 p = 0.0001), speed of information processing (k = 5; d = 0.44; CI = 0.22–0.65; z = 4.02 p < 0.0001), working memory (k = 6; d = 0.50; CI = 0.34–0.66; z = 6.09 p < 0.0001), and delayed memory (k = 3; d = 0.34; CI = 0.07–0.6, z = 2.49 p = 0.02). The association between LBP intensity and psychological factors and cognitive function was inconclusive. More studies are needed to explore these associations and improve evidence in this field. The results of this study suggest that cognitive aspects should be considered during the rehabilitation process of patients with LBP and raise further questions, including whether individuals with LBP are at a greater risk of developing dementia or whether targeting cognitive function will increase the probability of success of LBP treatment. These questions should, also, be considered in future studies.
Horizontally acquired fungal killer protein genes affect cell development in mosses
Authors: Guan Yanlong , Ma Lan , Wang Qia , Zhao Jinjie , Wang Shuanghua , Wu Jinsong , Liu Yang , Sun Hang , Huang Jinling 
Published: December 2022

SUMMARYThe moss Physcomitrium patens is crucial for studying plant development and evolution. Although the P. patens genome includes genes acquired from bacteria, fungi and viruses, the functions and evolutionary significance of these acquired genes remain largely unclear. Killer protein 4 (KP4) is a toxin secreted by the phytopathogenic fungus Ustilago maydis that inhibits the growth of sensitive target strains by blocking their calcium uptake. Here, we show that KP4 genes in mosses were acquired from fungi through at least three independent events of horizontal gene transfer. Two paralogous copies of KP4 (PpKP4‐1 and PpKP4‐2) exist in P. patens. Knockout mutants ppkp4‐1 and ppkp4‐2 showed cell death at the protonemal stage, and ppkp4‐2 also exhibited defects in tip growth. We provide experimental evidence indicating that PpKP4‐1/2 affects P. patens protonemal cell development by mediating cytoplasmic calcium and that KP4 genes are functionally conserved between P. patens and fungi. The present study provides additional insights into the role of horizontal gene transfer in land plant development and evolution.
How Teacher Verbal Prompting and Demonstrated Modeling Correlate to Preschooler’s Physical Activity Levels
Authors: Carroll Alexandra V. , Spring Katherine E. , Winkler Darby , Suire Kameron , Wadsworth Danielle D. 
Published: December 2022

Background: Teacher-led strategies targeting verbal prompting and demonstrated modeling can increase preschoolers’ physical activity levels; however, it is unknown which strategy promotes higher levels. The purpose of this study was to explore whether teacher verbal prompting or demonstrated modeling elicits higher levels of physical activity among preschoolers. Methods: Participants included 117 (56 females and 61 males; mean = 3.77 y) preschoolers who were observed for 3 days during regular preschool instructions. The System for Observing Student Movement in Academic Routines and Transitions observation system assessed verbal prompting and demonstrated modeling of the teachers, and preschoolers wore an ActiGraph accelerometer to measure physical activity. Results: The multivariate analysis of variance results showed a significant difference for verbal prompting (P < .001), demonstrated modeling (P = .032), light physical activity (P < .001), and moderate to vigorous physical activity (MVPA; P < .001) between segments of the preschool day. A stepwise linear regression showed that preschooler’s MVPA (P = .005) and light physical activity and MVPA (P = .036) were significantly related to demonstrated modeling, but not verbal prompting. During indoor time, light physical activity and MVPA were highest during large group, work time, and morning group, where teacher demonstrated modeling occurred the most. Conclusions: Teacher demonstrated modeling had a significant relationship to preschoolers’ MVPA and light physical activity levels, while teacher verbal prompting did not.
Effects of Mental Fatigue on Strength Endurance: A Systematic Review and Meta-Analysis
Authors: Alix-Fages Carlos , Grgic Jozo , Jiménez-Martínez Pablo , Baz-Valle Eneko , Balsalobre-Fernández Carlos 
Published: December 2022

The purpose of the present systematic review and meta-analysis was to explore the effects of mental fatigue on upper and lower body strength endurance. Searches for studies were performed in the PubMed/MEDLINE and Web of Science databases. We included studies that compared the effects of a demanding cognitive task (set to induce mental fatigue) with a control condition on strength endurance in dynamic resistance exercise (i.e., expressed as the number of performed repetitions at a given load). The data reported in the included studies were pooled in a random-effects meta-analysis of standardized mean differences. Seven studies were included in the review. We found that mental fatigue significantly reduced the number of performed repetitions for upper body exercises (standardized mean difference: −0.41; 95% confidence interval [−0.70, −0.12]; p = .006; I2 = 0%). Mental fatigue also significantly reduced the number of performed repetitions in the analysis for lower body exercises (standardized mean difference: −0.39; 95% confidence interval [−0.75, −0.04]; p = .03; I2 = 0%). Our results showed that performing a demanding cognitive task—which induces mental fatigue—impairs strength endurance performance. Collectively, our findings suggest that exposure to cognitive tasks that may induce mental fatigue should be minimized before strength endurance-based resistance exercise sessions.