bluuebunny/crossref_metadata_2025_split huggingface dataset:
MOSPD2 a new endoplasmic reticulum-lipid droplet tether functioning in LD homeostasis
Authors: Zouiouich Mehdi , Di Mattia Thomas , Martinet Arthur , Eichler Julie , Wendling Corinne , Tomishige Nario , Grandgirard Erwan , Fuggetta Nicolas , Ramain Catherine , Mizzon Giulia , Dumesnil Calvin , Carpentier Maxime , Reina-San-Martin Bernardo , Mathelin Carole , Schwab Yannick , Thiam Abdou Rachid , Kobayashi Toshihide , Drin Guillaume , Tomasetto Catherine , Alpy Fabien 
Published: February 2022

AbstractMembrane contact sites between organelles are organized by protein bridges. Among the components of these contacts, the VAP family comprises endoplasmic reticulum (ER)-anchored proteins, such as MOSPD2, functioning as major ER-organelle tethers. MOSPD2 distinguishes itself from the other members of the VAP family by the presence of a CRAL-TRIO domain. In this study, we show that MOSPD2 forms ER-LD contacts thanks to its CRAL-TRIO domain. MOSPD2 ensures the attachment of the ER to LDs through a direct protein-membrane interaction involving an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs. Remarkably, the absence of MOSPD2 markedly disturbs the assembly of lipid droplets. These data show that MOSPD2, in addition to being a general ER receptor for inter-organelle contacts, possesses an additional tethering activity and is specifically implicated in the biology of LDs via its CRAL-TRIO domain.
Timely Schwann cell division during migration drives peripheral myelination in vivo via Laminin/cAMP pathway
Authors: Mikdache Aya , Boueid Marie-José , Lesport Emilie , Delespierre Brigitte , Loisel-Duwattez Julien , Degerny Cindy , Tawk Marcel 
Published: February 2022

SummarySchwann cells (SC) migrate along peripheral axons and divide intensively to generate the right number of cells prior to axonal ensheathment; however, little is known regarding the temporal and molecular control of their division, particularly during migration, and its impact on myelination. We report that Sil, a spindle pole protein associated with autosomal recessive primary microcephaly (MCPH), is required for temporal mitotic exit of SC. In sil-deficient cassiopeia (csp-/-) mutants, SC fail to radially sort and myelinate peripheral axons. Elevation of cAMP, but not Rac1 activity in csp-/- restores myelin ensheathment. Most importantly, we show a significant decrease in Laminin expression within csp-/- posterior lateral line nerve and that forcing Laminin2 expression in csp-/- fully restores SC ability to myelinate. We also discovered that SC have a restricted time window during which they have to divide, while migrating, in order to trigger myelination. Thus, we unravel a novel and essential role for timely SC division during migration in mediating Laminin expression to orchestrate radial sorting and peripheral myelination in vivo.
Crest maturation at the cardiomyocyte surface contributes to a new late postnatal development stage that controls the diastolic function of the adult heart
Authors: Karsenty Clément , Guilbeau-Frugier Céline , Genet Gaël , Seguelas Marie-Hélène , Alzieu Philippe , Cazorla Olivier , Montagner Alexandra , Blum Yuna , Dubroca Caroline , Maupoint Julie , Tramunt Blandine , Cauquil Marie , Sulpice Thierry , Richard Sylvain , Arcucci Silvia , Flores-Flores Remy , Pataluch Nicolas , Montoriol Romain , Sicard Pierre , Deney Antoine , Couffinhal Thierry , Sénard Jean-Michel , Galés Céline 
Published: February 2022

AbstractRATIONALEIn addition to its typical rod-shape, the mammalian adult cardiomyocyte (CM) harbors a unique lateral membrane surface architecture with periodic crests, relying on the presence of subsarcolemmal mitochondria (SSM) the role of which is still unknown.OBJECTIVETo investigate the development and functional role of CM crests during the postnatal period.METHODS AND RESULTSElectron/confocal microscopy and western-blot of left ventricular tissues from rat hearts indicated a late CM surface crest maturation, between postnatal day 20 (P20) and P60, as shown by substantial SSM swelling and increased claudin-5 cell surface expression. The P20-P60 postnatal stage also correlates with an ultimate maturation of the T-Tubules and the intercalated disk. At the cellular level, we identified an atypical CM hypertrophy characterized by an increase in long- and short-axes without myofibril addition and with sarcomere lateral stretching, indicative of lateral stretch-based CM hypertrophy. We confirmed the P20-P60 hypertrophy at the organ level by echocardiography but also demonstrated a transcriptomic program after P20 targeting all the cardiac cell populations. At the functional level, using Doppler echocardiography, we found that the P20-P60 period is specifically dedicated to the improvement of relaxation. Mechanistically, using CM-specific knock-out mice, we identified ephrin-B1 as a determinant of CM crest maturation after P20 controlling lateral CM stretch-hypertrophy and relaxation. Interestingly, while young adultEfnb1CMspe−/−mice essentially show a relaxation impairment with exercise intolerance, they progressively switch toward heart failure with 100% KO mice dying after 13 months.CONCLUSIONSThis study highlights a new late P20-P60 postnatal developmental stage of the heart in rodents during which the CM surface crests mature through an ephrin-B1-dependant mechanism and regulate the diastolic function. Moreover, we demonstrate for the first time that the CM crest architecture is cardioprotective.
Hebbian and homeostatic plasticity mechanisms are segregated in sub-types of layer 5 neuron in the visual cortex
Authors: Pandey Anurag , Hardingham Neil , Fox Kevin 
Published: February 2022

AbstractCortical layer 5 contains two major types of projection neuron known as IB (intrinsic bursting) cells that project sub-cortically and RS (regular spiking) cells that project between cortical areas. We studied the plasticity properties of RS and IB cells in the visual cortex during the critical period for ocular dominance plasticity in mice. RS neurons exhibited synaptic depression in response to both dark exposure (DE) and monocular deprivation (MD), and their homeostatic recovery from depression was dependent on TNFα. In contrast, IB cells demonstrated opposite responses to DE and MD, potentiating to DE and depressing to MD. IB cells’ potentiation depended on CaMKII-autophosphorylation and not TNFα. IB cells showed mature synaptic properties at the start of the critical period while RS cells matured during the critical period. Together with observations in somatosensory cortex, these results suggest that differences in RS and IB plasticity mechanisms are a general cortical property.Significance StatementThe neocortex contains cells that project to different locations in the brain. In this study we show that neurons projecting to different target locations exhibit different synaptic plasticity mechanisms. Cortically projecting cells show synaptic depression and homeostatic up-regulation, subcortically projecting cells show classical Hebbian potentiation. This is important because it implies that the way a cortical neuron responds to experience and encodes information depends on the neuronal subcircuits in which it is embedded. We show that ignoring this distinction leads to erroneous conclusions regarding plasticity time-course and significance. These findings constitute an important step toward understanding how learning and memory is organized within subcircuits in the cerebral cortex.
Digital Skills for Performance: a framework for assessing current and future digital skills needs in the performing arts sector
Authors: Webb Aleksandra , Layton James 
Published: February 2022

PurposeThe COVID-19 pandemic has accelerated the need to embrace digital ways of producing work and reaching audiences in the hard-hit sectors such as performing arts. In the context of post-pandemic recovery, this paper explores the notion of digital performance and proposes a framework for categorisation of digital skills currently associated with the digital making and sharing of performance work. It also aims to review the current digital skills offering in the performing arts training at Scottish universities and suggests strategies to drive accelerated digital skills development in performance education.Design/methodology/approachLiterature on digitalisations, digital skills and digital performance have been reviewed to provide the context and inform the proposed Digital Skills for Performance Framework. Subsequently, a pilot desk-based study selected 15 Scottish Higher Education Institutions in the area of performance and analysed their publicly available programme documentation for the presence of digital skills.FindingsWhile all of the programme specifications mentioned the use of “digital portfolios” and “digital performance”, there was little specific detail concerning “baseline” (transferable) and “specific” (technical) digital skills such as competency in the use of specific technologies. More notably, there was a complete absence of content relating to digital aesthetic identity.Originality/valueUpskilling future performance makers in digital competencies seems particularly important at present. This paper offers a useful categorisation of the digital skills in performing arts context, which higher education programmes can use to update their curricula, prepare the work-ready graduates and explore technological opportunities for the sector's long-term post-pandemic recovery.
Identification of markers and artificial intelligence-based classification of radical Twitter data
Authors: Fraiwan Mohammad 
Published: February 2022

Purpose
Social networks (SNs) have recently evolved from a means of connecting people to becoming a tool for social engineering, radicalization, dissemination of propaganda and recruitment of terrorists. It is no secret that the majority of the Islamic State in Iraq and Syria (ISIS) members are Arabic speakers, and even the non-Arabs adopt Arabic nicknames. However, the majority of the literature researching the subject deals with non-Arabic languages. Moreover, the features involved in identifying radical Islamic content are shallow and the search or classification terms are common in daily chatter among people of the region. The authors aim at distinguishing normal conversation, influenced by the role religion plays in daily life, from terror-related content.

Design/methodology/approach
This article presents the authors' experience and the results of collecting, analyzing and classifying Twitter data from affiliated members of ISIS, as well as sympathizers. The authors used artificial intelligence (AI) and machine learning classification algorithms to categorize the tweets, as terror-related, generic religious, and unrelated.

Findings
The authors report the classification accuracy of the K-nearest neighbor (KNN), Bernoulli Naive Bayes (BNN) and support vector machine (SVM) [one-against-all (OAA) and all-against-all (AAA)] algorithms. The authors achieved a high classification F1 score of 83\%. The work in this paper will hopefully aid more accurate classification of radical content.

Originality/value
In this paper, the authors have collected and analyzed thousands of tweets advocating and promoting ISIS. The authors have identified many common markers and keywords characteristic of ISIS rhetoric. Moreover, the authors have applied text processing and AI machine learning techniques to classify the tweets into one of three categories: terror-related, non-terror political chatter and news and unrelated data-polluting tweets.
Conformable fractional order controller design and optimization for sensorless control of induction motor
Authors: Ilten Erdem 
Published: February 2022

Purpose
In recent years, use of sensorless control methods for electrical motor-based variable speed drive systems has been increasing rapidly to compensate the increasing costs in industrial systems. Also, use of induction motors is popular for a long time to decrease the cost of these industrial systems. This study aims to design an effective controller to improve the sensorless speed control performance of induction motor. To achieve this, a conformable fractional order proportional integral (CFOPI) controller is designed.

Design/methodology/approach
The system is modeled based on small signal analysis by using the input–output data, experimentally. To do this, system identification toolbox of Matlab is used. The proposed controller is established on conformable fractional integral approach proposed by Khalil et al. (2014). CFOPI controller coefficients are optimized using particle swarm optimization method on the created small signal-based simulation model of the system to minimize the integral time absolute error. To prove the success of the proposed method, a traditional fractional order proportional integral (TFOPI) controller is tested under the same experimental system with the CFOPI controller.

Findings
TFOPI and CFOPI controllers are tested with the optimum parameters. Reference and actual speed trends are obtained for both methods. In induction motor start-up test, settling-times are measured as 8.73 and 8.44 s and steady-state oscillations are 2.66% and 0% (almost) for TFOPI and CFOPI controllers, respectively. In variable referenced speed tracking test, CFOPI performs well at all speed levels, while TFOPI fails to reach the reference speed at most speed levels.

Practical implications
Proposed CFOPI control method can be easily implemented in industrial systems, thanks to its simple algorithm. digital signal peripheral interface controller (dsPIC) based driver circuit with designed CFOPI controller used in this study can be applied directly to industrial systems such as elevators, conveyors, cranes and drills. Moreover, it can improve the performance of induction motor-based variable speed drive systems.

Originality/value
The proposed method provides robust performance for induction motor used in control systems. Additionally, it does this by using less complex algorithm written on the processors according to the traditional fractional order controllers.
Social learning, innovative adaptation and community resilience to disasters: the case of flash floods in Bangladesh
Authors: Haque C. Emdad , Azad M. Abul Kalam , Choudhury Mahed-Ul-Islam 
Published: February 2022

PurposeExisting literature on how social learning stemming from flood experience influences management and adaptation to flood-risks, and resilience-building is scant. In this context, the purpose of this study is to map the processes and examine the application of social learning in formulating coping measures and adaptation strategies in Bangladesh's wetland communities.Design/methodology/approachTo bridge this research gap, conceptually, we formulated the Social Learning from Disasters (SLD) Framework to explain the process of social learning from flood experience and the mechanism of its influence on community resilience. Applying a qualitative research approach, the empirical investigation was carried out in the Fenarbak Union of Sunamganj District, Bangladesh. Using a participatory approach and qualitative techniques, the required primary data were procured.FindingsThe results of the study yielded three key findings: (1) social learning and memory have often enabled wetland communities to adopt diverse coping and adaptive measures in response to flash floods; (2) social learning-based actions have resulted in reduced flood-risk and enhanced community resilience to flash floods, especially when these actions were supported by both local and external innovations and (3) the aforementioned social learning stemmed primarily from first-hand experience of flash floods, which was shared via various collective learning platforms.Research limitations/implicationsThe study followed a participatory methodology and the data were procured from two communities in the union level unit of Bangladesh. Therefore, generalization to apply to the larger context should be made with caution. Also, the study represents a cross-sectional study, and thus understanding of the long-term trend is not possible.Practical implicationsThe findings of the study have direct and profound implications for local community-level disaster-risk planning. As there are serious deficiencies in documenting and preserving social learning for community resilience and development planning, this study offers a conceptual framework, along with empirical evidence, for transforming these lessons learned into practical actions for change.Social implicationsThe findings of the study highlight the importance of social learning as a collective effort and provide empirical evidence of innovative adaptations to change. These results are critical to formulating societal strategies for disaster-risk management as well as to enhance community resilience.Originality/valueLimited efforts have hitherto been made to determine (1) how the actual process of social learning from disaster shocks takes place, and (2) how innovative adaptation strategies lead vulnerable communities to take up social learning-based actions. Our research attempts to fill these knowledge gaps by providing an evidence-based account of community resilience-building responses to flash flood disasters.
Follow the breath: mindfulness as travelling pedagogy
Authors: Low Remy 
Published: February 2022

PurposeThis article considers the ethical and political significance of mindfulness by treating it as a pedagogy – that is, as a way of cultivating particular human capacities in response to a specific situation. It puts forward an approach for evaluating its implications not by recourse to a predetermined moral meter, but by locating it within specific historical and geographical contexts as mediated biographically by individual teachers.Design/methodology/approachDrawing on Edward Said's concept of “traveling theory”, this article proposes an approach called “travelling pedagogy” that sensitises the researcher to how the interplay of temporal, spatial, and biographical factors shape reiterations of any pedagogy. It then uses this conceptual framework to explore how mindfulness has been taught by three of its prominent proponents: Thich Nhat Hanh, Jon Kabat-Zinn, and bell hooks.FindingsThe exploration of how mindfulness has been taught by the three prominent teachers featured in this article demonstrates how its ethico-political implications transform under varied conditions of urgency faced by these teachers, respectively: war and militarisation; scientific legitimacy; racialised and gendered capitalism. This points to how a historical approach might add nuance to the discussions and debates on mindfulness beyond overgeneralised hype on the one hand, and sweeping “McMindfulness” critiques on the other.Originality/valueThis article proposes a new conceptual framework for evaluating the ethical and political significance of mindfulness – and indeed any form of pedagogy – by tracking it at the nexus of history, geography, and biography. By conceiving of mindfulness as a travelling pedagogy, it also counsels a more worldly consideration of its implications beyond beatific celebration and patrician contempt.
Congregating as a social phenomenon; the social glue that binds
Authors: MacCarthy Martin , Morgan Ashlee , Lambert Claire 
Published: February 2022

PurposeThis study aims to consolidate and hone existing spectating and crowd theory. This is achieved by marrying socio-cultural ideas and concepts from related disciplines.Design/methodology/approachThis conceptual review examines what people do when they congregate at an event, and in doing so, answers the question of what they forgo when denied a crowd. Concepts are teased from the literature as to what happens during participatory congregation (in company,in situ), punctuated by relegation without it.FindingsRelated concepts are organised into a typology. The metamodel is the essence of the paper and includes four themes: (1) identity construction, (2) interacting with others, (3) producing and co-producing the event and (4) the allure of tribalism.Research limitations/implicationsThe paper is conceptual and therefore a typology (not a taxonomy). This implies that while it is likely transferable, it is not generalisable. It is manual and subjective, as opposed to objective and automatic. Notwithstanding future research implications, it is intended to inform those considering running virtual events.Practical implicationsEvent organisers are informed as to the “what” and “why” of running community events. It encourages a more circumspect, humanistic view that events are not merely a source of revenue.Social implicationsThis review contributes a macro understanding of human nature, complementing a micro understanding of crowd behaviour.Originality/valueVirtual event management is a relatively new and burgeoning field. Prior to the Pandemic an event without a crowd was almost inconceivable.
Manager see manager do: the impact of geographic herding on corporate social responsibility
Authors: Nofsinger John , Patterson Fernando M. , Shank Corey 
Published: February 2022

PurposeThe authors examine how local firms, regardless of industry, influence each other's corporate policies. The authors argue that there are two motives for why local firms may have similar corporate social responsibility (CSR) policies. First, the peer effect argues that a firm's chief executive officer (CEO) will likely interact regularly with fellow CEOs of local firms, especially those of similar size, influencing each other's firm to make similar decisions. Second, firms may believe that CSR policies can be used to attract local talent. That is, if there are many firms in the area, employees may elect to work for the firm that treats their employees better or shares their values. Thus, to compete for labor resources, local firms will herd in similar CSR policies.Design/methodology/approachThrough regression analysis, the authors compare a firm's CSR policies to the policies of other firms in the geographic area (within 100 miles).FindingsThe authors find support for the peer effect hypothesis, as local firms of the same size positively and significantly affect a firm's own CSR score. In contrast, local firms of different sizes have a negative relationship. The combination of CSR scores being related to the CSR scores of similar sized firms and not to other size firms suggest that the peer effect dominates the labor pool effect.Originality/valueThrough regression analysis, the authors compare a firm's CSR policies to the policies of other firms in the geographic area.