bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circular RNA Rap1b promotes Hoxa5 histone acetylation by recruiting Kat7 to inhibit neuronal apoptosis in acute ischemic stroke
Authors: Zhang Fangfang , Zhao Lin , Lu Yu , Dong Xin , Liu Yanqi , Li Yu , Guo Shuang , Zheng Siyuan , Xiao Ying , Jiang Yuzhu , Zhang Liang 
Published: May 2022

Abstract
Stroke is a common neurological disease and one of the major causes of permanent morbidity and disability worldwide. Although many drugs have shown significant neuroprotective effects in animal models, these results have not been confirmed in human clinical trials. Therefore, search for new treatments is urgent. In human patients and animal stroke models, acute ischemic primary neurons with blocked arterial blood supply die rapidly, while core and surrounding acute ischemic primary neurons that are infused by other arteries undergo delayed apoptosis to some extent. In the present study, we found that circRAP1B was downregulated in patients with acute ischemia stroke (AIS), and it was validated that circRap1b was downregulated in the hippocampus tissues and neurons HT22 cells of C57BL/6J mice treated with acute ischemia-hypoxia (AIS). Moreover, overexpression of circRAap1b inhibited the apoptosis of HT22-AIS cells. We attempted to prove that neuronal apoptosis inhibited by circRap1b/Hoxa5 in vitro might be ascribed to Kat7-induced acetylation of histones H3 Lysine 14 modification in the Hoxa5 promoter region. Promisingly, we hope that circRap1b and Hoxa5 will provide new treatment strategy for stroke.
Clinical analysis of risk factors of acquired immunodeficiency syndrome complicated with pulmonary tuberculosis
Authors: She Li-jun , Zhang Xin , Liu Shi-fu , Ma Jian-hui , Cao Jin-feng 
Published: May 2022

Abstract
Objective
To analyze the risk factors of acquired immunodeficiency syndrome(AIDS)complicated with pulmonary tuberculosis༈PTB༉, so as to provide a reference for better treatment and prevention .
Methods
A retrospective analysis of 939 AIDS patients admitted to our hospital from January 2016 to January 2021 was divided into AIDS combined PTB group (group A, 68 cases) and AIDS group (group B, 871 cases) according to whether they were complicated with PTB. The clinical and laboratory data were analyzed and compared between the two groups.
Results
There were no significant differences between the two groups in gender, residence, occupation, annual income, educational level, marital status, drinking history, history of diabetes, history of BCG vaccination, homosexuality, and whether there were multiple sexual partners at the same time (P > 0.05). ). There were significant differences in smoking history and the number of CD4 + cells (200 cells/mm3 as the boundary), with χ2 = 8.98 and χ2 = 9.65, respectively, P < 0.05.
Conclusion
Smoking history and CD4 + cell count < 200 cells/mm3 were risk factors for AIDS complicated with PTB.
In Silico Analyses Reveal the Relationship Between ROCK2 Mutations and Laterality Defects
Authors: Wang Pengcheng , Liu Sijie , Li Tingting , Chen Sun , Li Fen , Sun Kun , Xu Rang 
Published: May 2022

Abstract
Laterality defects is a class of congenital disorders resulting from abnormalities in left-right (L-R) axis patterning. Previous studies indicated that the duplication of Rho-associated coiled-coil containing protein kinase 2(ROCK2) had connection with laterality disorders in human and its knockdown led to significant L-R abnormalities in Xenopus and Zebrafish. In this study, we aimed to investigate the association between the mutations of ROCK2 and L-R development in vertebrate. We analyzed a cohort of 65 patients with laterality defects and validated the ROCK2 mutations by polymerase chain reaction (PCR) and direct sequencing. Multiple in silico tools were used to predict the pathogenicity of mutations. We screened out two novel (ROCK2-Q115H, ROCK2-Y416C) and a third rare (ROCK2-A1013T) ROCK2 mutations. The two novel mutations Q115H and Y416C may alter protein properties and impact protein functions.Conclusions: ROCK2-Q115H and ROCK2-Y416C are predicted to be pathogenic and could in part give rise to influence the biological activities of ROCK2 with the change of physicochemical properties and spatial conformation, suggesting that the mutations of ROCK2 may play a role in the pathogenesis of laterality defects.
Assessment of Cement Content in Cured Concrete by Chemical Study
Authors: Bajad Mohankumar N. 
Published: May 2022

Abstract
An effort was made in this investigation to determine the cement content in cured concrete. A test procedure used to determine calcium oxide which further leads to the assessment of cement in concrete that has been hardened was applied to the laboratory test. The content of cement of three different concrete samples that have been hardened of known proportions was precisely determined by applying the simplified California Test 403 procedure. The California Test 403 method originally used in order to determine the calcium oxide concentration in hardened concrete has been simplified by modifying several steps. The test results are verified by parameter determination of the composition in concrete by X-ray diffraction (XRD) using the JCP (Joint Committee of powder diffraction standards file) database. Good agreement between the results obtained by the titration and analytical methods of the instrument and the actual results is observed.
Predictors of mortality in bicycle-related trauma: an eight-year experience in a level one trauma center.
Authors: Reitano Elisa , Cioffi Stefano Piero Bernardo , Virdis Francesco , Altomare Michele , Spota Andrea , Chiara Osvaldo , Cimbanassi Stefania 
Published: May 2022

Abstract
Background: Bicycle-related trauma has increased during the last decades, mainly thanks to the antipollution environmental policies and the diffusion of bike-sharing companies. This study investigates the outcome of bicycle-related trauma in our level one trauma center over a period of eight years.Methods: Data of 446 consecutive bicycle-related trauma admitted to our trauma center from 2011 to 2019 were selected and retrospectively analysed. The sample was divided into 3 age groups: ≤ 17 years, 18–54 years, and ≥ 55 years. Mortality rates were obtained for the overall population and patients with Injury Severity Score (ISS) ≥ 25. Month and seasonal patients’ distribution was described to provide an epidemiological overview of bike-related trauma over the years.Results: Patients ³ 55 years showed a lower pre-hospital and in-hospital GCS (p≤ 0.001), higher levels of lactates (p< 0.019) and higher ISS (p≤ 0.001), probability of death (p≤ 0.001), and overall mortality (p≤ 0.001). The head and chest Abbreviated Injury Scale (AIS) ≥3 injuries were predictors of mortality, especially in patients over 55 years (p<0.010). However, more than 90% of patients wore a helmet. Patients less than 18 years old showed the higher survival rate (98.7%; Log-rank test ≤ 0.028). Bicycle-related trauma were more frequent during the summer (34%), particularly in July and August.Conclusions: Age over 55 years old, head and chest injuries, and an ISS > 25 were independent predictors of mortality. Multiple factors probably contributed to mortality rates in these patients.
Effectiveness of Leksell gamma knife hypophysectomy on cancer-related intractable pain – a single-center experience
Authors: May Jaromir , Liščák Roman 
Published: May 2022

Abstract
Purpose: Hypophysectomy is a method used in analgesia in patients with painful bone metastases. The pain relief after this procedure is not pathophysiologically fully understood. In only a few studies Leksell gamma knife (LGK) was used for radiosurgical hypophysectomy. In our study, we performed the LGK hypophysectomy in patients with intractable cancer-related pain due to bone metastases and evaluated the impact of this method on pain relief.Methods: From 1994 to 2020 we enrolled 20 patients with the diagnosis of disseminated carcinoma. All patients underwent radiosurgical hypophysectomy on LGK. The prescription dose was 75-100Gy on the 50% isodose line, and the maximal dose on the optic pathways was 9,8Gy on average. Results: In all 10 evaluated patients pain relief was achieved (0-50% of pre-procedural pain). The hypophysectomy effect lasted for the rest of their lives (the mean follow-up period was 12,6 months). In three patients we observed hormonal disbalance - hypocortisolism and diabetes insipidus with good response to substitutional therapy, one patient developed a temporary abducens nerve palsy. No other adverse events were observed.Conclusion: Our results suggest that the LGK hypophysectomy is an effective and safe procedure to reduce cancer-related intractable pain, especially in bone metastases of hormonally dependent tumors.
Retrodictive Quantum Computing
Authors: Ortiz Gerardo , Carette Jacques , Sabry Amr 
Published: May 2022

Abstract
Quantum evolution is time-reversible and yet little
advantage is gained from this in the circuit model of quantum
computing. Indeed, most quantum algorithms expressed in the circuit model compute strictly from the present to the future, preparing initial states and proceeding forward with unitary transformations and measurements. We may call this predictive computation. In contrast, retrodictive quantum theory, retrocausality, and the time-symmetry of physical laws all suggest that quantum computation embodies richer --untapped-- modes of computation, which could exploit knowledge about the future for a computational advantage.

We demonstrate that by using symbolic partial evaluation, retrodictive reasoning can indeed be used as a computational resource that exhibits richer modes of computation at the boundary of the classical/quantum divide. Specifically, instead of fully specifying the initial conditions of a quantum circuit and computing forward, it is possible to compute, classically, in both the forward and backward directions starting from partially-specified initial and final conditions. Furthermore, this mixed mode of computation (i) can solve problems with fewer resources than the conventional forward mode of execution, sometimes even purely classically (de-quantization), (ii) can be expressed in a symbolic representation that immediately exposes global relational properties of the wavefunction that are needed for quantum algorithms and (iii) reveals that the entanglement patterns inherent in genuine quantum algorithms with no known classical counterparts are artifacts of the chosen symbolic representation.
Essential Emergency and Critical Care as a health system response to critical illness and the COVID19 pandemic: What does it cost?
Authors: Guinness Lorna , Kairu Angela , Kuwawenaruwa August , Khalid Karima , Awadh Khamis , Were Vincent , Barasa Edwine , Shah Hiral , Baker Peter , Schell Carl Otto , Baker Tim 
Published: May 2022

Abstract
Essential Emergency and Critical Care (EECC) is a novel approach to the care of critically ill patients, focusing on first-tier, low-cost care and designed to be feasible even in low-resourced and low-staffed settings. This is distinct from advanced critical care, usually conducted in ICUs with specialised staff, facilities and technologies. This paper estimates the incremental cost of EECC and advanced critical care for the planning of care for critically ill patients in low resource settings with Kenya and Tanzania as case studies.The incremental costing took a health systems perspective. A normative approach based on the ingredients defined through the recently published global consensus on EECC was used. The setting was a district hospital in which the patient is provided with the definitive care typically provided at that level for their condition. Quantification of resource use was based on COVID-19 as a tracer condition using clinical expertise. Local prices were used where available, and all costs were converted to USD2020.The costs per patient day of EECC is estimated to be 1.01 USD, 10.83 USD and 32.84 USD in Tanzania and 1.76 USD, 14.86 USD and 37.43 USD in Kenya, for moderate, severe and critical COVID-19 patients respectively. The cost per patient day of advanced critical care is estimated to be 13.11 USD and 17.33 USD for severe and 297.30 USD and 369.64 USD for critical COVID-19 patients in Tanzania and Kenya, respectively.EECC, an approach of providing the essential care to all critically ill patients, is low-cost. The components of EECC are basic and universal and, when assessed against the existing gaps in critical care coverage and costs of advanced critical care, suggest that it should be a priority area of investment for health systems around the globe.
Quantitative study of vertebral body changes in ovariectomized rats by spectral CT combined with DXA
Authors: Guo Xingman , Shao Yan , Yu Xiyue , Yao Qianqian , Chen Huafang , Qin Jian 
Published: May 2022

Abstract
Background: With the application of material decomposition and monoenergetic imaging reconstruction technology of spectral CT in the musculoskeletal system, the purpose of this study was to explore the quantitative changes of L5 vertebral body in ovariectomized rats by spectral CT Gemstone Spectral Imaging (GSI) and dual energy X-ray absorption (DXA).Methods: Spectral CT GSI and DXA scans of the forty rats were conducted at 0 (baseline), 4, 8 and 12 weeks after operation. Hydroxyapatite (HAP)/fat value, 74KeV monoenergetic CT value and bone mineral density (BMD) of L5 vertebral body were measured. After excessive anesthesia, L5 vertebral body was taken for histological observation. Results: There was significant difference in HAP(fat) value between groups at 4, 8 and 12 weeks after operation (P<0.05), and the significant difference in 74KeV monoenergetic CT value and BMD at 8 and 12 weeks after operation (P<0.05). There was also a positive correlation between 74KeV monoenergetic CT value and BMD of L5 vertebral body in OVX group. From 4 weeks after operation, the L5 of the OVX group showed sparse loss of the trabecular interconnectivity, thinning of the trabeculae and widened intertrabecular spaces.Conclusion: Spectral CT material decomposition technology can be used to detect the bone state of vertebral body in the early stage of estrogen deficiency and has the better sensitivity than the BMD.
Towards Understanding the Nexus between Pastoral Care, Social Media, and Sustainable Development in the Post-COVID-19 Era
Authors: Afolaranmi Adebayo Ola 
Published: May 2022

Abstract
COVID-19 has changed the world tremendously as the world is now living in the “new normal”. Pastoral care has to respond to this new normal especially through social media in order to be relevant in the post-COVID-19 era and contribute to the sustainable development of the society. Therefore, this paper attempts to explore the relationship between pastoral care, social media and the sustainable development of the society relevant in the post-COVID-19 era. Semi-structured interview sessions were held with some purposively sampled pastors in the Ibadan metropolis. It was discovered that while many pastors have started adapting to the use of social media in their pastoral care, there are still many challenges that these pastors are facing that are impairing the sustainable development of the society. Based on the findings of this research, this researcher postulates a new theory of pastoral care through social media for sustainable development. The paper concludes with some recommendations for pastors, church members, the government and the populace at large.
Chemical composition, antibiofilm and anticancer effect of different propolis extracts collected from Mila (Algeria)
Authors: Nasirli Farid , Daikh Amina , Arslan Sevki , Segueni Nerimane , Mutlu Dogukan , Dogan Nazime Mercan 
Published: May 2022

Abstract
The chemical contents, antibiofilm and anticancer effects of different propolis extracts (petroleum ether, chloroform, ethyl acetate and methanol) collected from Mila (Algeria) were investigated in this study. Chemical analysis showed the presence flavonoids as a major compound. The highest antibiofilm activity was observed at the 200 µg/ml methanol fraction (92%). Florescent microscope images also confirmed antibiofilm effect. Our results showed that the structure of biofilm treated with propolis was degraded and there were no water channels seen in the biofilm structure. In addition, the density of dead cells in the biofilm was also noted with fluorescent staining. According to FTIR analysis, it was found that propolis caused some changes in macromolecules on the cell surface. Cytotoxic activity of propolis (EC50: 97–117 µg/ml) was determined by MTT test. Propolis extracts caused a significant increase in mRNA levels of proteins involved in tumor suppression and apoptosis in the MDA-MB-231 cell line and induced apoptosis. Western blot analysis confirmed these results. As a result, it can be said that Algerian propolis has anticancer and antibiofilm effective compounds.
Surface Premelting and Melting of Colloidal Glasses
Authors: Zhang Qi , Li Wei , Qiao Kaiyao , Han Yilong 
Published: May 2022

Abstract
The nature of liquid-to-glass transition is a major puzzle in science because little structural change causes drastic dynamic slowdown1. A similar challenge exists in glass-to-liquid transition, i.e. glass melting, but it has been poorly explored. In particular, the surface effects on glass are not well understood2, especially in melting3–6. Here, we assemble monolayer, bilayer and trilayer colloidal glasses composed of tunable attractive spheres by vapour deposition such that they are sufficiently stable to melt from the surface3, 5, in contrast to bulk melting of ordinary glasses3. The measured particles’ trajectories reveal that structural and dynamic parameters reach their bulk values at different depths, which define a surface liquid layer and an intermediate glassy layer. The thicknesses of both layers increase in power laws upon approaching the glass transition point, similar to surface liquid growth in crystal premelting. The power law exponents are robust for both layers under slow and fast temperature changes, and for monolayer and multilayer samples. The power-law temperature dependence of the structural parameters on the surface and their centrosymmetric profiles are similar to crystal premelting7. The profiles of dynamic parameters follow the prediction of the cooperative-string model for the surface mobile layer of glass8. Under the fast temperature change across the glass transition point, the centrosymmetric density profile and constant speed and width of the melting front are similar to crystal melting9. These results suggest that premelting and melting can be generalised from crystals to amorphous solids.
Transcatheter Aortic Valve Implantation (TAVI) versus Surgical Aortic Valve Replacement (SAVR): A Retrospective Analysis from a Tertiary Care Hospital
Authors: Khan Muhammad Ammad , Alam Ghanwa 
Published: May 2022

Abstract
Background: Since Pakistan is adapting to the technological advancements in the procedure, and shifting to Transcatheter Aortic Valve Implantation , more studies are required to evaluate the safe and efficacy of the procedure. The data on the topic is scarce, and our study will aim to fill in the literature gap. Furthermore, by looking at the burden of cardiac diseases, a policy implementation could be put in place to guide prevention and treatment in the country. We aim to evaluate the efficacy of Transcatheter Aortic Valve Implantation procedure and decide whether its a sustainable, cost effective enough of an option when compared to standard open heart surgery in the setting of low and middle income country Results: A higher Postoperative Complication Rate was observed with Surgical Aortic Valve Replacement compared with Transcatheter Aortic Valve Implantation. Among Surgical Aortic Valve Replacement patients the most common complications were postoperative bleeding, infection and cardiac tamponade. Patients who underwent Transcatheter Aortic Valve Implantation had higher incidence of other postoperative complications which were vascular complications and need for pacemaker implantation. On comparison the two groups did show significant differences in the mortality rate. Conclusions Transcatheter Aortic Valve Implantation has Low Postoperative Complication Rate and Mortality Rate compared to Surgical Aortic Valve Replacement. Our Data confirm that Transcatheter Aortic Valve Implantation is a safer and more reliable procedure for Patients suffering from Aortic Stenosis.
WITHDRAWN: Cylindrical Screen--- Rotating Grating Around Three Axes (6)
Authors: peng hui 
Published: May 2022

Abstract

The orientation-dependence of the diffraction patterns of the transmission grating experiments have been systematically studied by rotating the transmission grating around three axes. We made the cylindrical screen to study the orientation-dependence of the patterns of the grating.The cylindrical screen is practical to show the angle-dependent of patterns and to indicate the locationsof each order for CCD to collect the digit data that may be used to study the theories of rotating grating.
PKIB regulates tamoxifen resistance in estrogen receptor-positive breast cancer through inhibition of autophagy
Authors: SUN LU , ZONG BEIGE , LI FEI , QIAO YINA , TING JIN , WANG YIHUA , ZHANG YINGZI , JIN YUDI , LIU SHENGCHUN 
Published: May 2022

Abstract
Tamoxifen is a first-line adjuvant endocrine drug used in the treatment of patients with estrogen receptor (ER)-positive breast cancer. The drug’s therapeutic benefit is limited by the development of resistance due to alterations in autophagy function. In this study, the role of the cAMP-dependent protein kinase inhibitor-β (PKIB) in autophagy and the development of tamoxifen-resistant breast cancer were evaluated. Expression of PKIB was assessed by RTq-PCR, Western blot analysis, and immunohistochemistry (IHC) in tamoxifen-resistant and sensitive breast cancer cell lines and clinical samples. Knockdown and overexpression of PKIB were used to determine the sensitivity to tamoxifen in vitro and the status of autophagy. Further, immunofluorescence and Western blot analysis were used to explore the tamoxifen resistance mechanism of PKIB. CREB/ATG7 signaling activation was evaluated after knocking down of PKIB in MCF7 and T47D cells. The level of PKIB expression was upregulated in the tamoxifen-sensitive breast cancer cell lines (MCF7 and T47D) and in primary tumor tissues. Knock down of PKIB decreased the sensitivity to tamoxifen both in vitro and in vivo, and significantly enhanced the autophagy level in the tamoxifen-sensitive cell lines. In contrast, overexpression of PKIB inhibited autophagy and restore tamoxifen sensitivity in tamoxifen-resistant cells. Moreover, an increase in p-CREB and ATG7 protein expression levels were observed in MCF7/si2-PKIB and T47D/si2-PKIB cells by Western blot. Finally, Kaplan-Meier curve analysis also indicated that the high level of PKIB predicts a good prognosis in breast cancer. Overall, our findings demonstrated that PKIB suppresses CREB/ATG7 activation and subsequent autophagy which could contributes to tamoxifen resistance in breast cancer.