bluuebunny/crossref_metadata_2025_split huggingface dataset:
Culturally Adapted Motivational Interviewing with Cognitive Behavior Therapy and Mindfulness Based Relapse Prevention for Substance Use Disorder in Pakistan (CAMAIB): Protocol of a feasibility factorial randomised controlled trial
Authors: ASIF MUQADDAS , Khoso Ameer B , Husain M Ali , Shahzad Salman , Hout Marie-Claire Van , Rafiq Noor-ul-Zaman , Lane Steven , Chaudhry Imran Bashir , Husain Nusrat 
Published: October 2022

Abstract
Background
The use of psychoactive substances significantly impacts the health, social and economic aspects of families, communities and nations. There is a need to develop and test psychological interventions aimed for people with Substance Use Disorder (SUD) in Lower and Middle Income Countries (LMICS), such as in Pakistan. The aim of this exploratory trial is to test the feasibility and acceptability of two culturally adapted psychological interventions in a factorial Randomized Controlled Trial (RCT).
Methods
The proposed project will be conducted in three phases. The first phase of the study will focus on cultural adaptation of the interventions through qualitative interviews with key stakeholders. The second phase will be to refine the intervention and to produce manual assisted intervention. Third and last stage would be to assess the feasibility of the culturally adapted interventions through a factorial RCT. The study will be carried out in Karachi, Hyderabad, Peshawar, Lahore and Rawalpindi, Pakistan. Recruitment of participants will take place from primary care and volunteer organisations/drug rehabilitation centres. A total of 260 individuals diagnosed with SUD (n=65) in each of the four arms will be recruited. The intervention will be delivered weekly over a period of 12 weeks in both individual and group setting. Assessments will be carried out at baseline, at 12th week (after completion of intervention) and 24th week post-randomisation. The analysis will determine feasibility of recruitment, randomisation, retention and intervention delivery. Acceptability of intervention will be determined in terms of adherence to intervention i.e. the mean number of sessions attended, number of home assignments completed, attrition rates as well as through process evaluation to understand the implementation process, context, participants’ satisfaction, and impact of study intervention. The health resource use and impact on the quality of life will be established through health economic data.
Discussion
This study will provide evidence for feasibility and acceptability of culturally adapted manually assisted psychological interventions for people with SUD in the context of Pakistan. The study will have clinical implications if intervention is proven feasible and acceptable.
Trial registration
Name of the registry: ClinicalTrials.gov
Trial registration number: NCT04885569
Date of registration: 25th April 2021, retrospectively registered
URL of trial registry record: https://clinicaltrials.gov/ct2/show/NCT04885569
A structure-based gamma evaluation method for identifying clinically relevant dose differences in organs at risk
Authors: Yu Liting , Baker Anthony , Kairn Tanya , Livingstone Alexander , Trapp Jamie , Crowe Scott B 
Published: October 2022

Abstract
Purpose
Gamma evaluation is currently the most widely used dose comparison method for patient specific quality assurance (PSQA). However, existing methods for normalising the dose difference, using either the dose at the global maximum dose point or at each local point, can respectively lead to under- and over-sensitivity to dose differences in organ-at-risk structures. This may be of concern for plan evaluation from clinical perspectives. This study has explored and proposed a new method called structural gamma, which takes structural dose tolerances into consideration while performing gamma analysis for PSQA.
Methods
As a demonstration of the structural gamma method, a total of 78 retrospective plans on four treatment sites were re-calculated on an in-house Monte Carlo system and compared with doses calculated from the treatment planning system. Structural gamma evaluations were performed using both QUANTEC dose tolerances and radiation oncologist specified dose tolerances, then compared with conventional global and local gamma evaluations.
Results
Results demonstrated that structural gamma evaluation is especially sensitive to errors in structures with restrictive dose constraints. The structural gamma map provides both geometric and dosimetric information on PSQA results, allowing straightforward clinical interpretation.
Conclusion
The proposed structure-based gamma method accounts for dose tolerances for specific anatomical structures. This method can provide a clinically useful method to assess and communicate PSQA results, offering radiation oncologists a more intuitive way of examining agreement in surrounding critical normal structures.
Concealed penis in pediatric age group; A comparison between three surgical techniques
Authors: Elrouby Ahmed 
Published: October 2022

Abstract
Background: Comparison between three different surgical techniques in the management of concealed penis.
Methods: This prospective interventional non-randomized study included 150 pediatric patients with concealed penis. They were distributed equally into three groups; group A; patients treated by anchoring the penile skin dermis to Buck's fascia at the penile base at 3 & 9 o'clock points using PDS 5/0 (phallopexy), group B; patients treated by complete dissection and excision of dartos fascia & group C; patients treated by phallopexy as in group A after complete dissection and excision of dartos fascia. Follow-up at the end of the 1st post-operative week and then monthly for 6 months as regards penile skin congestion and/or necrosis, wound infection, edema, and/or re-retraction was carried out.
Results: Penile edema and re-retraction have a statistically significant difference among the studied groups (p< 0.001& p= 0.002 respectively). Penile re-retraction was lowest in patients of group C and penile edema was lowest in patients of group B.
Conclusions: Phallopexy after complete dissection and excision of dartos fascia have better results than doing either phallopexy or dartos excision alone in the treatment of concealed penis
Basilar Artery Diameter as Neuroimaging Biomarker in Chinese Fabry Disease Patients
Authors: Lam Yan Lok Tiffany , Sheng Bun , Kwok Hoi Ming , Yu Ellen Lok Man , Ma Ka Fai Johnny 
Published: October 2022

Abstract
Background: Fabry disease (FD) is an X-linked lysosomal storage disease resulting from mutations of α-galactosidase A gene, and has been emphasized as one of the etiologies of young stroke and leukoencephalopathy. Vertebrobasilar dolichoectasia (VBD) is a highlighted finding in FD. We aim to examine the utility of VBD in Chinese FD by comparing the differences in basilar artery (BA) diameter of Chinese FD patients against age-matched controls with and without stroke.
Methods: This was a matched case-control study involving 37 Chinese FD patients. The BA diameters were evaluated on axial T2-weighted magnetic resonance imaging and compared to two age-and-gender matched control groups, one with stroke and one without. The association between BA diameter and stroke occurrences and white matter hyperintensities (WMH) were analyzed among all FD patients.
Results: Patients with FD had significantly increased BA diameter compared to controls with and without stroke (p<0.001). A BA diameter of 4.16mm could distinguish FD from controls in the stroke subgroup (ROC AUC 0.870, p=0.001, sensitivity 80% specificity 100%), and with a cut-off of 3.21mm in the non-stroke subgroup (ROC AUC 0.846, p<0.001, sensitivity 77.8% specificity 88.9%). Larger BA diameter had more stroke occurrences and was moderately associated with heavier WMH load in terms of higher total FAZEKAS scores. (Spearman’s rho=0.423, p=0.011).
Conclusion: VBD was also present in Chinese FD patients. BA diameter has high diagnostic utility in identifying FD from a mixed cohort of stroke and normal controls, and carried predictive value in evaluating neurological complications of FD.
Radiological Society of North America (RSNA) 3D Printing Special Interest Group (SIG) clinical situations for which 3D printing is considered an appropriate representation or extension of data contained in a medical imaging examination: Breast Conditions
Authors: Arribas Elsa M. , Kelil Tatiana , Santiago Lumarie , Ali Arafat , Chadalavada Seetharam C. , Chepelev Leonid , Ghodadra Anish , Ionita Ciprian N. , Lee Joonhyuk , Ravi Prashanth , Ryan Justin , Sheikh Adnan M. , Rybicki Frank J. , Ballard David H. 
Published: October 2022

Abstract
The use of medical 3D printing has expanded dramatically for breast diseases. A writing group composed of the Radiological Society of North America (RSNA) Special Interest Group on 3D Printing (SIG) provides updated appropriateness criteria for breast 3D printing in various clinical scenarios. Evidence-based appropriateness criteria are provided for the following clinical scenarios: benign breast lesions and high-risk breast lesions, breast cancer, breast reconstruction, and breast radiation (treatment planning and radiation delivery).
Role of Social Determinants of Health in Differential Respiratory Exposure and Health Outcomes Among Children
Authors: Puvvula Jagadeesh , Poole Jill , Gwon Yeongjin , Rogan Eleanor , Bell Jesse 
Published: October 2022

Abstract
Background: Attributes defining the Social Determinants of Health (SDoH) are associated with disproportionate exposures to environmental hazards and differential health outcomes among communities. The dynamics between SDoH, disproportionate environmental exposures, and differential health outcomes are often specific to micro-geographic areas.
Methods: This study focused on children less than 20 years of age who lived in Douglas County, Nebraska, during 2016-2019. To assess the role of SDoH in differential exposures, we evaluated the association between SDoH metrics and criteria pollutant concentrations and the association between SDoH and pediatric asthma exacerbations to quantify the role of SDoH in differential pediatric asthma outcomes. The Bayesian Poisson regression model with spatial random effects.
Results: We identified significant positive associations between the annual mean concentration of criteria pollutants (carbon monoxide, particulate matter 2.5, nitrogen dioxide, sulfur dioxide) with race (Non-Hispanic Black and Hispanic/Latino), financial stability, and literacy. Additionally, there were significant positive associations between higher rates of pediatric asthma emergency department visits and neighborhoods with more Non-Hispanic Black children, children without health insurance coverage, and households without access to a vehicle.
Conclusions: Non-Hispanic Black and Hispanic/Latino children living in Douglas County, NE experience disproportionately higher exposure to criteria pollutant concentrations. Additionally, higher rates of asthma exacerbations among Non-Hispanic Black children could be due to reduced access to respiratory care that is potentially the result of financial instability and vehicle access. These results could inform city planners and health care providers to mitigate respiratory risks among these higher at-risk populations.
Exploring the Challenges and Opportunities of Implementing Industry 4.0 in Jordan: Public Shareholding Manufacturing Companies Perspective
Authors: Abu-Rumman Ayman , AlSha'ar Hamzeh , Alqhaiwi Laith , Shraah Ata Al 
Published: October 2022

Abstract
Industry 4.0 (the fourth industrial revolution) involves swift and ongoing technological changes affecting industries and societies because of advanced automation, communication and data exchange, and global connectivity. While its implementation is necessary for organizational success in the face of international competition, many challenges arise with its opportunities. This research is an investigation of the challenges (employee qualification, employee acceptance, organizational, and production fit) and opportunities (strategic, operational, environmental, and social) in the implementation of Industry 4.0 in public shareholding manufacturing companies in Jordan. A questionnaire-based approach for primary data collection with analysis via Smart-PLS was taken. The results revealed that organizational and production fit challenges, strategic opportunities, operational opportunities, and environmental and social opportunities are positively associated with Industry 4.0 implementation, while employee qualification and acceptance challenges are negatively associated. The study explained that there is not enough knowledge about Industry 4.0. This study offers guidance for establishing regulations related to Industry 4.0 implementation by removing challenges and adopting opportunities. Also, this study is an approach for further research about the development of communications in Jordan and global connectivity.
Comparative analysis of the chloroplast genomes of Rosa species and RNA editing analysis
Authors: Gao Chengwen , Wu Chuanhong , Zhang Qian , Zhao Xia , Zhao Xiangzhong , Wu Mingxuan , Lian Yihong , Li Zhiqiang 
Published: October 2022

Abstract
Background
The genus Rosa (Rosaceae) contains approximately 200 species, most of which have high ecological and economic values. Chloroplast genome sequences are important for studying species differentiation, phylogeny, and RNA editing.
Results
In this study, the chloroplast genomes of three Rosa species, R. hybrida, R. acicularis, and R. rubiginosa, were assembled and compared with other reported Rosa chloroplast genomes. To investigate the RNA editing sites in R. hybrida (commercial rose cultivar), we mapped RNA-sequencing data to the chloroplast genome and analyzed their post-transcriptional features. Rosa chloroplast genomes presented a quadripartite structure and had highly conserved gene order and gene content. We identified four mutation hotspots (ycf3-trnS, trnT-trnL, psbE-petL, and ycf1) as candidate molecular markers for differentiation in the Rosa species. Additionally, 22 chloroplast genomic fragments with a total length of 6,192 bp and > 90% sequence similarity with their counterparts were identified in the mitochondrial genome, representing 3.96% of the chloroplast genome. Phylogenetic analysis revealed that the earliest divergence in the chloroplast phylogeny roughly distinguished species of sections Pimpinellifoliae and Rosa and subgenera Hulthemia, Platyrhodon, and Hesperhodos from species of sections Synstyale, Laevigatae, Banksianae, Caninae, and Chinenses. Moreover, DNA- and RNA-sequencing data revealed 19 RNA editing sites, including three synonymous and 16 nonsynonymous, in the chloroplast genome of R. hybrida that were distributed among 13 genes.
Conclusions
The genome structure and gene content of Rosa chloroplast genomes are similar across various species. Phylogenetic analysis based on the Rosa chloroplast genomes has high resolution. Additionally, a total of 19 RNA editing sites were validated by RNA-Seq mapping in R. hybrida. The results provide valuable information for RNA editing and evolutionary studies of Rosa and a basis for further studies on genomic breeding of Rosa species.
A global panel dataset of COVID-19 vaccination policies
Authors: Cameron-Blake Emily , Tatlow Helen , de Mello Bernardo Andretti , Boby Thomas , Green Kaitlyn , Hale Thomas , Petherick Anna , Phillips Toby , Pott Annalena , Wade Adam , Zha Hao 
Published: October 2022

Abstract
We present a global panel dataset of COVID-19 vaccine policies, with data from 01 January 2020 for 185 countries and a number of sub-national jurisdictions, reporting on vaccination prioritisation plans, eligibility and availability, cost to the individual, and mandatory vaccination policies. For each of these indicators, we recorded who is targeted by a policy using 53 standardised categories. These indicators document a detailed picture of the unprecedented scale of global COVID-19 vaccination rollout and strategy, indicating which countries prioritised and vaccinated which groups, when, and in what order. We highlight key descriptive findings from these data, to demonstrate uses for the data and to encourage researchers and policy makers in future research and vaccination planning. Numerous patterns emerge. For example: some countries prioritised border workers and economic sectors (“eliminator” countries), while others prioritised the elderly and healthcare sectors for the first COVID-19 vaccinations (“mitigator” countries); High Income Countries (HICs) published prioritisation plans and began vaccinations earlier than Low- and Middle-Income Countries (LMICs). Fifty-five countries were found to have implemented at least one policy of mandatory vaccination. We also demonstrate the value of combining this data with vaccination uptake rates, vaccine supply and demand data, and with further COVID-19 epidemiological data. (200 words).
Analyses of Familial Chylomicronemia Syndrome And Multifactorial Chylomicronemia In Colombia 2010-2020: A Cross-Sectional Study
Authors: Rodriguez Franklin Hanna , Alvarez Jorge Mario Estrada , Quintero Henry Mauricio Arenas , Nogueira Juan Patricio , Hurtado Gloria Liliana Porras 
Published: October 2022

Abstract
Background and aim

Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive metabolic disorder caused by mutations in genes involved in chylomicron metabolism. On the other hand, multifactorial chylomicronemia syndrome (MCS) is a polygenic disorder and the most frequent cause of chylomicronemia, which results from the presence of multiple genetic variants related to chylomicron metabolism, in addition to secondary factors. However, their clinical, paraclinical, and molecular features are not well established in our country. The objective of this study was to describe the development and results of a screening program for severe hypertriglyceridemia in Colombia.

Methods

A cross-sectional study was performed. All patients aged > 18 years with triglyceride levels ≥ 500 mg/dL from 2010 to 2020 were included. The program was developed in three stages: 1. Review of electronic records and identification of suspected cases, based on laboratory findings (triglyceride levels ≥ 500 mg/dL); 2. Identification of suspected cases, based on laboratory findings that had no relevant secondary factors; 3. Probable cases were identified as having an FCS score ≥ 8 and performing genetic tests in probable cases with available samples.

Results

In total, we categorized 2415 patients as suspected clinical cases with a mean age of 53 years, of which 68% corresponded to male patients. The mean triglyceride levels were 705.37 mg/dL (standard deviation [SD] 335.9 mg/dL). After applying the FCS score, 2.4% of patients met the probable case definition, of which only 18 accepted molecular test. Additionally, 7 patients had unique variants in the APOA5 gene (c.694T > C; p.Ser232Pro) or in the GPIHBP1 gene (c.523G > C; p.Gly175Arg), for an apparent prevalence of familial chylomicronemia in the consulting population of 1,2 per 100.000 patients with TG measurement. No previously reported pathogenic variants were detected.

Conclusion

This study describes a screening program for the detection of severe hypertriglyceridemia. Although we identified seven patients as carriers of a variant in the APOA5 gene, we diagnosed only one patient with FCS. We believe that more programs of these characteristics should be developed in our region, given the importance of early detection of this metabolic disorder.
Proton pump inhibitors/potassium-competitive acid blockers decrease pembrolizumab efficacy in patients with metastatic urothelial carcinoma
Authors: Iida Keitaro , Naiki Taku , Etani Toshiki , Nagai Takashi , Sugiyama Yosuke , Isobe Teruki , Aoki Maria , Nozaki Satoshi , Noda Yusuke , Shimizu Nobuhiko , Tomiyama Nami , Gonda Masakazu , Kamiya Hiroyuki , Kubota Hiroki , Nakane Akihiro , Ando Ryosuke , Kawai Noriyasu , Yasui Takahiro 
Published: October 2022

Abstract
Background
We elucidated the efficacy of gut microbiome–altering drugs on pembrolizumab efficacy in patients with metastatic urothelial carcinoma (mUC).
Methods
Clinical data were analyzed retrospectively from 135 mUC patients who received second-line pembrolizumab therapy between January 2018 and January 2021, following failed platinum-based chemotherapy. We evaluated the effects of gut microbiome–altering drugs (proton pump inhibitors [PPI]/potassium-competitive acid blockers [P-CAB], H2 blockers, antibiotics, non-steroidal anti-inflammatory drugs [NSAIDs], metformin, antipsychotics, steroids, and opioids), taken by patients within 30 days before/after pembrolizumab treatment, on progression-free survival (PFS) and overall survival (OS).
Results
Fifty-one patients received PPI/P-CAB (37/14, respectively); H2 blockers, 7; antibiotics, 35; NSAIDs, 22; antipsychotics, 8; metformin, 3; steroids, 11; and opioids, 29. Multivariate analysis excluded opioid and steroid use due to a significant correlation with previously reported predictive factors for disease progression or death. Multivariate analysis highlighted only PPI/P-CAB use as an independent prognostic factor for disease progression (hazards ratio: 1.63, 95% confidence interval: 1.08–2.45, p = 0.021) but not death (p = 0.123). Propensity score matching, including opioid and steroid use, revealed PPI/P-CAB users showed shorter PFS than non-PPI/P-CAB users (p = 0.006).
Conclusions
PPI/P-CAB may decrease the efficacy of pembrolizumab therapy for mUC, possibly via gut microbiome modulation.
Exploring the W chromosome: accumulation of retrotransposons contributes to sex chromosome differentiation in the willow beauty Peribatodes rhomboidaria (Lepidoptera: Geometridae)
Authors: Hejníčková Martina , Dalíková Martina , Zrzavá Magda , Marec František , Lorite Pedro , Montiel Eugenia E. 
Published: October 2022

Abstract
The evolution and molecular differentiation of heteromorphic sex chromosomes involves the accumulation of different repetitive DNA sequences due to restricted recombination. This also applies to moths and butterflies (Lepidoptera), which mostly have the WZ sex chromosome system. The female-specific W chromosome is typically rich in heterochromatin, harbours few or no genes and carries a large number of repetitive sequences. Molecular cytogenetic approaches such as comparative genomic hybridization (CGH) or fluorescence in situ hybridization (FISH) have shown that the W chromosome has evolved rapidly and varies widely among species. However, our knowledge of the composition of the W chromosome is still very limited. Here we present the analysis of repeats on the W chromosome in the willow beauty, Peribatodes rhomboidaria (Geometridae). RepeatExplorer comparative analysis of male and female genomes identified 10 putative W chromosome-enriched repeats, most of them being LTR or LINE mobile elements. We analysed two repeats with the largest difference between sexes: PRW LINE-like and PRW Bel-Pao. The results of FISH mapping and bioinformatic analysis confirm their W chromosome enrichment, thus supporting the hypothesis that mobile elements are the driving force of W chromosome differentiation in Lepidoptera.