bluuebunny/crossref_metadata_2025_split huggingface dataset:
DAMPAK FAKTOR VOLUME PENAWARAN SAHAM TERHADAP RISIKO SISTEMATIS : PENERAPAN DENGAN REGRESI DATA PANEL METODE COMMON EFFECT (STUDI PADA SAHAM-SAHAM DALAM JII DI BURSA EFEK INDONESIA PERIODE JANUARI – APRIL 2020) KAJIAN STUDI PADA KONDISI PANDEMI VIRUS
Authors: Sunaryo Sunaryo 
Published: February 2022

Abstrak. Penelitian ini bertujuan untuk mengetahui dampak Volume Penawaran Saham terhadap Risiko Sistematis. Penelitian ini menggunakan obyek saham-saham dalam kelompok JII (Jakarta Islamic Index) yang terdaftar di Bursa Efek Indonesia (BEI) untuk periode Januari hingga April 2020 dengan sampel jenuh (sensus sampling) sebagai metode. Terdapat 20 saham yang dipilih sebagai sampel. Metode analisis penelitian ini adalah regresi data panel dengan metode common effect. Penelitian menemukan hasil volume penawaran saham berpengaruh positif dan signifikan terhadap risiko sistematis.
Kata kunci: Volume Penawaran Saham dan Risiko Sistematis
Comparative Analysis of Cryopreservation Methods for Expanded Ex Vivo Natural Killer Cells: Recommendations for Optimizing Research Technologies
Authors: Ласюков Е.А. , Вашкевич Е.П. , Мухаметшина А.С. , Новикова М.А. , Липай Н.В. , Шман Т.В. 
Published: February 2022

Цель. На основании сравнительного анализа известных технологий криоконсервации экспансированных ex vivo естественных киллерных клеток рекомендовать к использованию наиболее эффективные в отношении сохранения жизнеспособности ЕК-клеток. Материалы и методы. В исследование было включено 10 образцов экспансированных ex vivo ЕК-клеток человека, замороженных в 4 типах криопротекторных смесей с использованием различных технологий заморозки и хранившихся в течение 30 суток в парах жидкого азота. Сохранность образцов после размораживания оценивали по показателям жизнеспособности, цитотоксической активности (ЦТА) и фенотипическому профилю клеток. Результаты. Среди исследованных нами криопротекторных смесей наилучшие показатели сохранения жизнеспособности и цитотоксической активности экспансированных ex vivo ЕК-клеток после криохранения были получены для двух вариантов смесей, в одной из которых ключевыми компонентами явились эмбриональная телячья сыворотка (ЭТС) (25%) и диметилсульфоксид (ДМСО) (10%), а во второй - декстран и ДМСО (5%). Заключение. Среди исследованных криопротекторных смесей наилучшие показатели сохранения жизнеспособности и цитотоксической активности экспансированных ex vivo ЕК-клеток после криохранения были получены для двух вариантов смесей: ключевыми компонентами одной из них являются ЭТС (25%) и ДМСО (10%); компонентами другой - декстран и ДМСО (5%).
Purpose. On the basis of a comparative analysis of known cryopreservation technologies for expanded ex vivo natural killer cells, to recommend for use the most effective NK cells in terms of preserving the viability. Materials and methods. The study included 10 samples of expanded ex vivo human EK cells, frozen in 4 types of cryoprotective mixtures using various freezing techniques and stored for 30 days in liquid nitrogen vapor. The safety of the samples after thawing was assessed in terms of viability, cytotoxic activity, and phenotypic cell profile. Results. Among the cryoprotective mixtures studied by us, the best results of preserving the viability and cytotoxic activity of expanded ex vivo NK cells after cryostorage were obtained for two variants of mixtures: the key components of the first mixture are FBS (25%) and DMSO (10%); the second components are dextran and DMSO (5%). Conclusion. Among the studied cryoprotectant, the best results of viability and cytotoxic activity of expanded ex vivo EK cells after cryostorage were obtained for two variants of agents: the key components of one of them are ETS (25%) and DMSO (10%); the other components are dextran and DMSO (5%).
Immunosuppressive Potential of Placenta-Derived Mesenchymal Stem Cells
Authors: Лях Е.Г. , Исайкина Я.И. , Шитикова М.Г. , Новикова М.А. , Савич Ю.В. , Жерносеченко А.А. 
Published: February 2022

Введение. Мезенхимальные стволовые клетки (МСК) модулируют иммунный ответ путем взаимодействия с широким спектром иммунных клеток. Одним из источников МСК является послеродовая плацента, преимуществом использования которой является доступность исходного материала. Цель. Исследование иммунных взаимодействий между Т-лимфоцитами и МСК, полученными из различных тканей плаценты в смешанной культуре. Материалы и методы. С помощью проточной цитофлуориметрии устанавливали количество Т-лимфоцитов (CD3+) и их основных субпопуляций: Т-хелперов с иммунофенотипом CD3+CD4+ и цитотоксических Т-лимфоцитов (CD3+CD8+) на ранней и поздней стадиях активации по экспрессии CD38 и HLA-DR соответственно. Результаты. Иммуносупрессивная активность МСК, полученных из амниотической оболочки, хориона и децидуальной ткани плаценты, не различалась, и все МСК достоверно снижали пролиферацию активированных CD3+ лимфоцитов, Т-хелперов и цитотоксических Т-лимфоцитов (p<0,05) как на стадии ранней активации, так и на стадии поздней. Установлено, что плацентарные МСК и МСК костного мозга сопоставимо редуцируют количество CD3+ лимфоцитов. Заключение. МСК плаценты могут служить перспективным материалом для клеточной иммунотерапии.
Introduction. Mesenchymal stem cells (MSCs) modulate the immune response by interacting with a wide range of immune cells. A full-term placenta is one of the source MSCs with the easily accessible features. Purpose. To study the immune interactions between T lymphocytes and MSCs obtained from various tissues of the placenta in a mixed culture. Materials and methods. Using flow cytometry, the number of cells in the subpopulations of T lymphocytes CD3+, CD3+CD4+, CD3+CD8+at the early (CD38+) and late (HLA-DR+) stages of activation was determined. Results. The results showed that the immunosuppressive activity of MSCs obtained from the amniotic membrane, chorion, and decidual tissue of the placenta did not differ, and all MSCs significantly reduced the proliferation of activated CD3+ lymphocytes, T helper cells and cytotoxic T lymphocytes (p<0.05), at the early and late stage of activation. It was found that placental MSCs and bone marrow MSCs reduced the number of CD3+ lymphocytes in a comparable manner. Conclusion. Placental MSCs could serve as a promising material for cell based immunotherapy.
Graft-Versus-Host Disease after Prophylactic Donor Lymphocytes Infusion in Children with Acute Leukemia and JMML
Authors: Цветкова Л.А. , Паина О.В. , Кожокарь П.В. , Фролова А.С. , Рахманова Ж.З. , Екушов К.А. , Субора Н.В. , Шевелева П.В. , Доценко А.А. , Семенова Е.В. , Кулагин А.Д. , Зубаровская Л.С. 
Published: February 2022

Профилактические инфузии донорских лимфоцитов используют у пациентов с высоким риском развития рецидива заболевания после алло-ТГСК. Данные по безопасности раннего введения ИДЛ у детей крайне ограничены. В работе отражены частота клинически значимой реакции «трансплантат против хозяина» (РТПХ) и ее связь с общей и безрецидивной выживаемостью. Проанализированы 37 детей с острыми лейкозами и ЮММЛ, получивших профилактические ИДЛ в течение первых 6 месяцев после алло-ТГСК. Развитие острой/хронической РТПХ средней степени выявлено у 7 из 37 детей (19%), не отмечено тяжелых форм РТПХ. Наиболее часто диагностировали кожную форму хронической РТПХ в сочетании с поражением печени. Случаи летальности, связанные с осложнениями после ИДЛ, не были зарегистрированы. Напротив, индукция острой/хронической РТПХ улучшала показатели безрецидивной выживаемости и не влияла на общую выживаемость, p=0,04 и p=0,3 соответственно.
Prophylactic donor lymphocytes infusion (DLI) is used in patients with a high risk of relapse after allo-HSCT. The data about safety of early start DLI in children are extremely limited. This study demonstrates the incidence of clinically significant graft versus host disease (GVHD) and correlation with overall and disease-free survival. We analyzed 37 children with acute leukemia and JMML, who had received prophylactic DLI within the first 6 months after HSCT. Moderate acute/chronic GVHD was diagnosed in 7/37 children (19%), nobody developed severe GVHD. The most children had chronic GVHD with involvement of skin and liver. There were no cases GVHD-related mortality. The induction of acute/chronic GVHD improved the relapse-free survival and did not influence on overall survival, p=0.04 and p=0.3, respectively.
Treatment of Large Plasmacytoma in Patients with Multiple Myeloma (Clinical Case)
Authors: Терентьева М.А. , Искров И.А. , Козак О.Н. , Траханов Д.Э. 
Published: February 2022

Множественная миелома на сегодняшний день из разряда неизлечимых заболеваний перешла в разряд хронических. Улучшение общей выживаемости связано с включением в лечение высокодозной химиотерапии с последующей аутологичной трансплантацией гемопоэтических стволовых клеток, а также с использованием в лечении новых классов препаратов. Обычно у пациентов с множественной миеломой пролиферация клональных плазматических клеток ограничена костным мозгом. Однако у части пациентов также развивается экстрамедуллярная миелома, характеризующаяся присутствием клональных плазматических клеток за пределами костного мозга. С точки зрения клинического исхода наличие экстрамедуллярной плазмоцитомы на момент постановки диагноза ассоциировано с неблагоприятным прогнозом. Рецидив заболевания в виде экстрамедуллярной плазмоцитомы характеризуется более агрессивным течением с длительностью общей выживаемости менее 6 месяцев. В качестве методов лечения используют лучевую терапию, хирургическое лечение, системную химиотерапию, однако результаты лечения пациентов с экстрамедуллярной плазмоцитомой остаются неудовлетворительными, и необходимы новаторские стратегии.
Сurrently the multiple myeloma has moved from the category of incurable diseases to the category of chronic ones. The improvement in overall survival is associated with the inclusion of high-dose chemotherapy in treatment, followed by autologous hematopoietic stem cell transplantation, as well as new classes of drugs in the treatment. Typically, in patients with multiple myeloma, clonal plasma cell proliferation is limited to the bone marrow. However, some patients also develop extramedullary myeloma, characterized by the presence of clonal plasma cells outside the bone marrow. As regards clinical outcome, the presence of extramedullary plasmacytoma at the time of diagnosis is associated with a poor prognosis. Relapse of the disease in the form of extramedullary plasmacytoma is characterized by a more aggressive course with an overall survival of less than 6 months. Radiation therapy, surgical treatment, and systemic chemotherapy are used as treatment options, but the results of ones in patients with extramedullary plasmacytoma remain unsatisfactory, and innovative strategies are required.
Gambaran Kejadian Kehamilan Ektopik Terganggu
Authors: Aravianti Ni Luh Sri , Darmapatni Made Widhi Gunapria , Somoyani Ni Ketut 
Published: February 2022

Ectopic pregnancies occur in 19,7 cases out of 1000 pregnancies, and is the leading cause of maternal death in the first trimester. Risk factors for disrupted ectopic pregnancy include age, gravidity, medical history, past obstetric history, and history of contraception. The purpose of this study was to describe the incidence of disrupted ectopic pregnancy at the Wangaya Regional General Hospital, Denpasar City. This type of study was descriptive with a cross sectional approach. The results of this study are the incidence of disrupted ectopic pregnancy occurred at an average age of 27.65 years, and the most at the age of 20-35 years, multigravida, without a history of sexually transmitted infections and pelvic inflammatory disease, without a history of disrupted ectopic pregnancy, abortion, caesarean section, and tubal surgery, and no history of contraception. The study suggest that pregnant women of productive age and multigravida to carry out more routine antenatal care and carry out ultrasound at least once in early pregnancy. In future study, it is recommended to use primary data.

Keywords: Disrupted ectopic pregnancy, Age, Gravidity, Medical history, Past Obstetrics History.
Faktor-Faktor yang Mempengaruhi Nyeri Punggung Ibu Hamil Trimester III: Literatur Review
Authors: Arummega Melati Nur , Rahmawati Alfiah , Meiranny Arum 
Published: February 2022

Back pain is caused by pain in the lumbosacral area. The increase in intensity with increasing gestational age results from a shift in the center of gravity and changes in body posture. Back pain from sacroiliac/lumbar can be a long term back pain if not treated promptly. Literature review aims to examine more deeply about back pain in pregnant women in the third trimester, there were factors that influence it by reviewing. Methods literature review by searching on Google Scholar and PubMed. The keyword criteria are "pregnancy", "back pain", "low back pain pregnancy factors", "back pain pregnant women activities". After the study was conducted, national articles 9 and 15 were obtained. Factors that affect back pain in third trimester pregnant women can be classified from gestational age, age, parity, daily activities that affect back pain and body relaxation can reduce back pain .

Keywords: Daily Activities, 3rd Trimester Of Pregnancy, Back Pain
Faktor Risiko Terjadinya Persalinan Prematur
Authors: Panada Sedianing Drastita  , Hardianto Gatut , Fitriana Farida , Utomo Martono Tri 
Published: February 2022

Preterm labor is an early delivery that occurs at gestational age after 20 weeks and before 37 weeks. In 2016, Indonesia was ranked 7th with the highest number of toddler deaths caused by compilations of premature birth. This study aims to analyze the relationship of risk factors dor preterm labor at RSU Dr. Wahidin Sudiro Husodo Mojokerto. The study was held from January until June in 2021. Research Method used analytic observasional with case control design. The instruments used is medical records. Analyse data used bivariate with Chi Square. The result age p = 0,005);anemia (p=0,018); PPROM (p =0,009); and previous preterm labor (p=0,49). The conclusions that age, anemia, and PPROM there are significant relationship with preterm labor statiscally. In this study there was no relationship between previous preterm labor with occurance of preterm labor in next pregnancies.

Keyword: Preterm Labor, Age, Anemia, PPROM, Previous Preterm Labor
INTERPROFESIONAL KOLABORASI DALAM PEMANTAUAN TUMBUH KEMBANG ANAK MELALUI PEMBERDAYAAN MASYARAKAT
Authors: Susilaningrum Rekawati , Utami Sri , Taufiqurrahman Taufiqurrahman 
Published: February 2022

Introduction: Anak balita yang mengalami gizi buruk dan gizi kurang masih relatif tinggi. Anak baduta (bawah 2 tahun) di Surabaya yang BGM sekitar 0,7%, sedangkan anak balita yang BGM sekitar 0,6%. Masalah gizi bisa berdampak pada tumbuh kembang balita. Perlu ada kerjama antar profesi untuk mengatasi masalah gizi dan tumbuh kembang balita. Tujuan. Meningkatkan kemampuan keluarga dalam pemantauan gizi dan deteksi tumbuh kembang pada anak balita melalui Interprofesional Collaboration.
Method: Pengabdian masyarakat ini dilaksanakan dengan pelatihan tentang pemantauan gizi dan tumbuh kembang balita. Pelatihan dilaksanakan secara kolaborasi oleh dosen dan mahasiswa Prodi D3 Kebidanan Sutomo, Prodi Sarjana Terapan Kebidanan dan Prodi D3 Gizi Poltekkes Kemenkes Surabaya. Materi pelatihan adalah tentang pemantauan gizi dan tumbuh kembang balita. Kegiatan dilaksanakan pada bulan Agustus 2021di wilayah puskesmas Sidotopo dengan jumlah peserta 20 ibu yang mempunyai anak balita
Results: Hasil kegiatan adalah untuk karakteristik ibu, usia terbanyak antara 21 sampai 35 tahun (80%), sebagian besar ibu rumah tangga (76,7%), hampir separo berpendidikan SD (40%). Karakteristik anak untuk usia terbanyak pada kelompok 12-17 bulan (23,3), lebih dari separo laki-laki (53,3%), hampir seluruhnya lahir aterm. Hasil pemantauan status gizi sekaligus pertumbuhannya, hampir seluruhnya dalam status gizi normal (90%) untuk BB/TB demikian juga untuk TB/U. Hasil pemantauan perkembangan juga diperoleh hasil hampir seluruhnya normal, namun ada 13,3% yang penilaian perkembangan meragukan. Setelah dilakukan pelatihan ada peningkatan nilai pengetahuan, sikap dan perilaku. Saat pre test, nilai rerata untuk pengetahuan, sikap dan ketrampilan sebesar 53, 46 dan 42. Setelah post test nilai rerata untuk pengetahuan, sikap dan ketrampilan sebesar 67, 71 dan 78.
Conclusion: Ada peningkatan pengetahuan, sikap dan perilaku ibu setelah dilakukan pelatihan. Tenaga kesehatan perlu selalu berkolaborasi untuk selalu mengingatkan ibu dalam mempertahankan kesehatan anaknya, tetap memantau dan memberikan stimulasi sesuai usianya dengan menggunakan buku KIA.
PMMA/Al2O3 bilayer passivation for suppression of hysteresis in chemically doped carbon nanotube thin-film transistors
Authors: Tan Fu Wen , Hirotani Jun , Kishimoto Shigeru , Ohno Yutaka 
Published: February 2022

Abstract
Hysteresis is usually present in carbon nanotube thin-film transistors exposed to air due to adsorbed water and oxygen molecules. Thus, it is desirable to passivate the device from these environmental effects and provide an air-stable platform for chemical doping to tune the threshold voltages. Here, we demonstrate p- and n-doped carbon nanotube transistors with suppressed hysteresis using bilayer stacking of poly(methyl methacrylate) and aluminum oxide (Al2O3) passivation layers using a low-temperature process suitable for flexible substrates. The results show that the bilayer passivation layers achieved reduced hysteresis to be 2.25% of applied gate voltage at low operation voltage as 2 V.
Infrastructure support for the economic security of business activities
Authors: Kharlamov A. V. , Aref’ev M. A. 
Published: February 2022

Aim. While investigating the socio-economic essence of infrastructure, the presented study aims to substantiate its increasing importance in ensuring the desired level of economic security of enterprises and the economic system as a whole.Tasks. The authors determine the relationship and mutual influence between the process of achieving the desired level of economic security of enterprises and the degree of infrastructure network development; specify and expand the classification of the economic security infrastructure support network according to new evaluation criteria; substantiate the increasing role of the government as the desired level of economic security of enterprises and the national economy as a whole is being achieved; justify the growing complexity of the process of infrastructure support for business activities with allowance for cyclicity and sectorality.Methods. This study analyzes and assesses the essence and role of infrastructure as an institution ensuring the normal operation of economic entities within the framework of the process approach. Research methods are used to summarize the obtained results and propose recommendations for increasing the effectiveness of the government’s regulatory role in the field of economic security and improvement of the infrastructure network.Results. According to the authors’ concept, the increasing importance of infrastructure as a developing institution contributing to the formation of a synergetic effect from the use of certain economic security instruments by various economic entities is substantiated. This concept can serve as a basis for a comprehensive solution to one of the most difficult tasks of our time — achieving the desired level of economic security of various economic entities.Conclusions. The study proves that infrastructure acts as one of the most important institutions of the modern economic system since the degree of its development determines the possibility of achieving the desired level of economic security. The authors propose an approach to organizing interaction between the elements of infrastructure support for economic activity with allowance for cyclicity and sectorality. The increasing importance of government regulation aimed at increasing the level of economic security of all economic entities is determined.
Making allowance for the trends and risks of ESG investing when managing a portfolio of financial assets
Authors: Sukhacheva V. V. , Bichurin O. M. 
Published: February 2022

Aim. The presented study aims to investigate the trends and risks of ESG investing.Tasks. The authors determine the causes of the increasing popularity of socially responsible investment and analyze the relationship between the company’s compliance with ESG factors, its financial indicators, and its stability in the market.Methods. This study uses general scientific methods of cognition to examine socially responsible investment in various aspects and to identify trends in managing a portfolio of financial assets.Results. The authors propose the fundamentals of creating a new methodological framework for assessing the level of social and environmental responsibility of companies and provide recommendations for including socially responsible investment in the stock portfolio.Conclusions. The increasing popularity of the social responsibility of business makes it impossible to ignore ESG investing in the stock portfolio. However, when investing in a business, it is necessary to pay attention to the correctness of the results of company valuation. The ratings do not make allowance for companies partially complying with ESG factors.
Sistem Informasi Penyewaan Lapangan Bulu Tangkis di Gedung Olahraga AUB Surakarta Berbasis Android
Authors: Nugroho Isadora , Rachmatullah Robby , Simanjuntak Ilnayati 
Published: February 2022

Gedung Olahraga AUB Surakarta adalah sebuah usaha yang bergerak dibisnis penyewaan lapangan bulu tangkis, masih menggunakan sistem manual yaitu pelanggan datang langsung kelokasi untuk menanyakan informasi jadwal penyewaan lapangan, lalu akan memesan jika tersedia lapangan yang kosong, transaksi akan dilakukan ketika calon penyewa datang pada jadwal yang telah ditentukan. Untuk membantu proses transaksi penyewaan maka dibuatkan sistem yang mampu mengolah transaksi penyewaan secara online, dan mempermudah pelanggan dalam mendapatkan informasi jadwal lapangan, informasi harga sewa dan dapat melakukan pemesanan secara online. Hasil perancangan sistem informasi pemesanan ini menggunakan metode pengembangan sistem waterfall. Untuk analisa kelemahan sistem menggunakan analisa PIECES (Perfomance, Information, Economy, Cotrol, Efficiency, dan Service).Sedangkan untuk menggambarkan alur data menggunakan yang terdiriflowchart sistem, usecase diagram, activity diagram, sequence diagram dan class diagram. Berdasarkan pengujian yang telah dilakukan menggunakan blackbox testing, sistem yang dibangun dapat membantu masalah yang dihadapi pengelola Gedung Olahraga AUB.
Inverter Pure Sinus sebagai Pengganti Genset Berbasis IoT
Authors: Widarti Erni , Nugroho Ernes Cahyo , Herawati Ratna , Ma’arif Muhamaad Naufal 
Published: February 2022

Pada jaman yang sudah maju ini teknologi menjadi peranan penting bagi masyarakat dimana perkembagan teknologi tidak lepas oleh sumber daya listrik yang mengakibatkan pihak PLN menambah daya bagi setiap lingkungan. Akan tetapi banyak pihak yang belum bisa merasakan kehadiran listrik terutama di daerah-daerah terpencil dan ini sangat mengganggu dalam aktivitas masyarakat. Sebagai alternatif untuk pemasokan listrik, banyak masyarakat menggunakan genset agar tidak mengganggu aktifitas atau pekerjaan masyarakat. Mengantisipasi adanya kejadian terputusnya aliran listrik dan kerusakan pada genset maka dibuatlah Inverter Pure Sinus. Inverter Pure Sinus ini berfungsi sebagai listrik cadangan sebagai langkah penggunaan listrik secara berkala. Inverter Pure Sinus yang banyak dijumpai dipasaran tidak bekerja secara optimal dan tidak dapat bekerja secara otomatis. Maka dilakukanlah penelitian menggunakan metode System Infrastructure Development Life Cycle for Enterprise Computing Systems (SIDLC), dari penelitian tersebt untuk menjawab dan mencoba dipecahkan dengan dibuatnya rangkaian intranstruktur Inverter Pure Sinus yang dapat bekerja secara otomatis dengan menggunakan modul ESP 8266 dan dapat dibawa kemanapun untuk sumber daya listrik.