bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol use is associated with affective and interoceptive network alterations in bipolar disorder
Authors: Martyn Fiona M. , McPhilemy Genevieve , Nabulsi Leila , Quirke Jacqueline , Hallahan Brian , McDonald Colm , Cannon Dara M. 
Published: November 2022

AbstractIntroductionAlcohol use in bipolar disorder (BD) is associated with mood lability and negative illness trajectory, while also impacting functional networks related to emotion, cognition, and introspection. The adverse impact of alcohol use in BD may be explained by its additive effects on these networks, thereby contributing to a poorer clinical outcome.MethodsForty BD‐I (DSM‐IV‐TR) and 46 psychiatrically healthy controls underwent T1 and resting state functional MRI scanning and the Alcohol Use Disorders Identification Test‐Consumption (AUDIT‐C) to assess alcohol use. Functional images were decomposed using spatial independent component analysis into 14 resting state networks (RSN), which were examined for effect of alcohol use and diagnosis‐by‐alcohol use accounting for age, sex, and diagnosis.ResultsDespite the groups consuming similar amounts of alcohol (BD: mean score ± SD 3.63 ± 3; HC 4.72 ± 3, U = 713, p = .07), for BD participants, greater alcohol use was associated with increased connectivity of the paracingulate gyrus within a default mode network (DMN) and reduced connectivity within an executive control network (ECN) relative to controls. Independently, greater alcohol use was associated with increased connectivity within an ECN and reduced connectivity within a DMN. A diagnosis of BD was associated with increased connectivity of a DMN and reduced connectivity of an ECN.ConclusionAffective symptomatology in BD is suggested to arise from the aberrant functionality of networks subserving emotive, cognitive, and introspective processes. Taken together, our results suggest that during euthymic periods, alcohol can contribute to the weakening of emotional regulation and response, potentially explaining the increased lability of mood and vulnerability to relapse within the disorder.
Association between prediabetes and cognitive function in Parkinson's disease
Authors: Park Joah , Choi Seohee , Kim Ryul 
Published: November 2022

AbstractIntroductionIt remains largely unknown whether prediabetes is related to cognitive impairment in Parkinson's disease (PD). This study aimed to assess the association between prediabetes and cognitive function in PD patients.MethodsIn this cross‐sectional study, 262 PD patients (age, 69.8 ± 10.3 years; Hoehn–Yahr stage, 2.3 ± 0.8) were classified into diabetes (glycated hemoglobin [HbA1c] ≥6.5% or previously diagnosed, n = 76), prediabetes (5.7%–6.4%, n = 90), or diabetes free (≤5.6%, n = 96) groups. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) test.ResultsBoth the diabetes and prediabetes groups had significantly lower MoCA scores (17.0 ± 6.6 and 18.0 ± 6.1, respectively) than the diabetes free group (20.0 ± 5.7), even after adjusting for potential confounders (p = .002 and p = .008, respectively). In the combined group of prediabetes and diabetes free patients, higher HbA1c levels significantly correlated with lower MoCA scores (p = .031). There was a significant interaction of diabetes status with age, but not with the duration of PD, on cognitive function.ConclusionIn addition to diabetes, prediabetes may negatively affect cognitive function in PD patients. Further prospective longitudinal studies are necessary to clarify the impact of prediabetes on the cognitive trajectory of these patients.
Antioxidant Activity, Total Phenolic, Tannin, and Flavonoid Content of Five Plants Used in Traditional Medicine in Penjamo, Guanajuato
Authors: Barajas‐Ramírez Jahir Antonio , Cabrera‐Ramírez Angel Humberto , Aguilar‐Raymundo Victoria Guadalupe 
Published: November 2022

AbstractIn Mexico, plants are commonly used to alleviate various ailments, including controlling some chronic degenerative diseases through the regular consumption of decoctions, infusions, and teas. However, there is little scientific evidence consolidating traditional medicine within health systems. Therefore, this work determined the phytochemical profile of the most used plants to treat various ailments (Cedro rojo, Cancerina, Ortiguilla, Hierba de la golondrina, Hierba de arlomo) and their general consumption as infusions. Aqueous and ethanolic extracts were generated, while the phytochemical compound content in the extracts obtained was quantified. The results indicate that the ethanolic extracts showed the highest phenolic compound and tannin content, with the highest contents for Cedro rojo (831.04 mg L−1) and Cancerina (864.80 mg L−1). The antioxidant activity was also determined, and a significant difference was observed (p<0.05). The extracts with the highest antioxidant capacity were the ethanolic extracts ranging from 250 to 907 μMET mL−1, while the aqueous extracts ranged from 112 to 390 μMET mL−1. The compounds identified by high‐performance liquid chromatography characterization on the aqueous extracts highlighted the presence of chlorogenic acid>cinnamic acid>quercetin. In ethanolic extracts, the presence of chlorogenic acid>cinnamic acid>quercetin>gallic acid>ferulic acid>coumaric acid was highlighted. The correlation between bioactive compounds, type of extract, and antioxidant activity suggests a significant affinity of these phytochemical compounds for the ethanol solvent. The results indicate that these plants are good sources of antioxidant phenolics and can be incorporated for use as functional beverages. However, more studies are needed to corroborate their beneficial effect.
A Review on Computational Fluid Dynamics Simulations of Industrial Amine Absorber Columns for CO2 Capture
Authors: Jamali Mohammad , Azari Ahmad 
Published: November 2022

AbstractCO2 emission is an important environmental issue leading to global climate change, notably an increase in global temperatures; therefore, it is so imperative to reduce CO2 emissions to the atmosphere. Absorption columns using amine‐based solutions are a promising approach for CO2 removal from industrial gas streams. Many modeling and simulation research have been performed on CO2 absorption columns in which computational fluid dynamics (CFD) strategy is very appropriate and well‐known. As CFD modeling and simulation is a fast‐developing method, the most recent review papers do not include the core research in this field of study. In this study, numerical simulations of CO2 absorption columns using CFD strategy have been carried out applying various types of amine‐based solutions. Furthermore, the effect of various types of packing mesh generation on the absorption columns' efficiency was studied. Investigation of synergetic influence such as application of various nanoparticles in different amine‐based solutionsand activators, double diameter packed bed absorption columns with different packings, rotating packed columns with double diameter are proposed for future studies.
Distance‐Triggered Distinct Aryl Migrations on Azidodiboranes
Authors: Liu Tong‐Tong , Chen Jiaxin , Guan Bing‐Tao , Lin Zhenyang , Shi Zhang‐Jie 
Published: November 2022

AbstractDerived from structurally similar precursors, two different azidodiboranes went through distinct aryl migration reactions triggered by different boron‐boron separation distances. Biphenylene based diborane with a shorter boron‐boron distance underwent heterolateral aryl migration to form a seven‐membered azadiborepin, while xanthrene based diborane with a longer boron‐boron distance afforded a stable bis‐azidoborane scaffold. The pyrolysis of such a bis‐azidoborane led to eight‐membered oxazadiborocine through homolateral aryl migration and subsequent [3+2] cycloaddition. Density functional theory (DFT) calculations unveiled that the boron‐boron separation distances were the intrinsic factors for the distinct migrations.
Clinical efficacy and safety comparison of Watchman device versus ACP/Amulet device for percutaneous left atrial appendage closure in patients with nonvalvular atrial fibrillation: A study‐level meta‐analysis of clinical trials
Authors: Bing Sun , Chen Rui Rui 
Published: November 2022

AbstractLeft atrial appendage occlusion is not inferior to oral anticoagulants in the prevention of stroke in several randomized controlled trials. However, the clinical efficacy and safety comparison of the Watchman and amplatzer cardiac plug (ACP)/Amulet devices for percutaneous left atrial appendage closure (LAAC) in patients with non‐valvular atrial fibrillation was controversial. A database search was conducted using PubMed, EMBASE, Cochrane Library, and Clinicaltrials.gov for trials that compared Watchman device vs ACP/Amulet device. The effective outcomes were stroke and systemic embolism. Safety outcomes were all‐cause death, cardiovascular death, and major bleeding. Device‐related complications included device‐related thrombus (DRT), peri‐device leaks (PDL > 5 mm). A total of 19 articles involving 6224 patients were included in the present study. The Watchman and ACP/Amulet groups comprised 3267 and 2957 patients, respectively. No statistically significant differences were detected in the stroke (odd ratio [OR]:1.24, 95% confidence interval [CI]: 0.92−1.67, p = .17, I2 = 0), systemic embolism (OR:1.10, 95% CI: 0.51−2.35, p = .81, I2 = 0%), all‐cause death (OR:0.97, 95% CI: 0.80−1.18, p = .77, I2 = 1%), cardiogenic death (OR:0.99, 95% CI: 0.77−1.29, p = .96, I2 = 0%), major bleeding (OR:1.18, 95% CI: 0.98−1.43, p = .08, I2 = 25%). DRT (OR:1.48, 95% CI: 1.06−2.06, p = .02, I2 = 0%) and PDL > 5 mm (OR:2.57, 95% CI: 1.63−4.04, p < .0001, I2 = 0%) were significantly lower in ACP/Amulet group compared to Watchman group. The effective and safety outcomes were comparable between two groups. ACP/Amulet group had significantly lower rates of DRT and PDL > 5 mm than Watchman group.
A phase 1 study to evaluate the safety, pharmacology, and feasibility of continuous infusion nelarabine in patients with relapsed and/or refractory lymphoid malignancies
Authors: Boddu Prajwal C. , Senapati Jayastu , Ravandi‐Kashani Farhad , Jabbour Elias J. , Jain Nitin , Ayres Mary , Chen Yuling , Keating Michael J. , Kantarjian Hagop M. , Gandhi Varsha , Kadia Tapan M. 
Published: November 2022

AbstractBackgroundNelarabine is a purine nucleoside analogue prodrug approved for the treatment of relapsed and refractory T‐cell acute lymphoblastic leukemia (R/R T‐ALL) and lymphoblastic lymphoma (T‐LBL). Although effective in R/R T‐ALL, significant neurotoxicity is dose‐limiting and such neurotoxicity associated with nucleoside analogues can be related to dosing schedule.MethodsThe authors conducted a phase 1 study to evaluate the pharmacokinetics and toxicity of nelarabine administered as a continuous infusion (CI) for 5 days (120 hours), rather than the standard, short‐infusion approach.ResultsTwenty‐nine patients with R/R T‐ALL/LBL or T‐cell prolymphocytic leukemia (T‐PLL) were treated, with escalating doses of nelarabine from 100 to 800 mg/m2/day × 5 days. The median age of the patients was 39 years (range, 14–77 years). The overall response rate was 31%, including 27% complete remission (CR) or CR with incomplete platelet recovery (CRp). Peripheral neuropathy was observed in 34% of patients, including four ≥grade 3 events related to nelarabine. Notably, there was no nelarabine‐related central neurotoxicity on study. The maximum tolerated dose was not reached. Pharmacokinetic data suggested no relationship between dose of nelarabine and accumulation of active intracellular ara‐GTP metabolite. Higher intracellular ara‐GTP concentrations were statistically associated with a favorable clinical response.ConclusionPreliminary evaluation of continuous infusion schedule of nelarabine suggests that the safety profile is acceptable for this patient population, with clinical activity observed even at low doses and could broaden the use of nelarabine both as single agent and in combinations by potentially mitigating the risk of central nervous system toxicities.
Effective Production of Selected Dioxolanes by Sequential Bio‐ and Chemocatalysis Enabled by Adapted Solvent Switching
Authors: Spöring Jan‐Dirk , Wiesenthal Jan , Pfennig Victoria S. , Gätgens Jochem , Beydoun Kassem , Bolm Carsten , Klankermayer Jürgen , Rother Dörte 
Published: November 2022

AbstractMost combinations of chemo‐ and biocatalysis take place in aqueous media or require a solvent change with complex intermediate processing. Using enzymes in the same organic solvent as the chemocatalyst eliminates this need. Here, it was shown that a complete chemoenzymatic cascade to form dioxolanes could be carried out in a purely organic environment. The result, including downstream processing, was compared with a classical mode, shifting solvent. First, a two‐step enzyme cascade starting from aliphatic aldehydes to chiral diols (3,4‐hexanediol and 4,5‐octanediol) was run either in an aqueous buffer or in the potentially biobased solvent cyclopentyl methyl ether. Subsequently, a ruthenium molecular catalyst enabled the conversion to dioxolanes [e. g., (4S,5S)‐dipropyl‐1,3‐dioxolane]. Importantly, the total synthesis of this product was not only highly stereoselective but also based on the combination of biomass, CO2, and hydrogen, thus providing an important example of a bio‐hybrid chemical.
Passive Daytime Radiative Cooling by Thermoplastic Polyurethane Wrapping Films with Controlled Hierarchical Porous Structures
Authors: Park Choyeon , Park Chanil , Park Sungmin , Lee Jaeho , Choi Jae‐Hak , Kim Yong Seok , Yoo Youngjae 
Published: November 2022

AbstractInvited for this month's cover is a combined work of the Korea Research Institute of Chemical Technology together with the Chungnam National University, the University of California, Irvine, and Chung‐Ang University. The cover shows the effective thermal management of a vehicle interior through the wrapping of stretchable passive radiative cooling film. Thermoplastic polyurethane (TPU) cooler film with a hierarchical porous structure shows a dramatic cooling effect compared to commercial paint in sunny, hot weather. The Research Article itself is available at 10.1002/cssc.202201842.
A case of groove pancreatitis with duodenal stenosis successfully treated by endoscopic ultrasonography‐guided pancreaticogastrostomy
Authors: Ikemura Muneo , Tomishima Ko , Ota Hiroto , Kabemura Daishi , Ushio Mako , Fukuma Taito , Takahashi Sho , Suzuki Akinori , Takasaki Yusuke , Ito Koichi , Ishii Shigeto , Fujisawa Toshio , Isayama Hiroyuki 
Published: November 2022

AbstractOne of the reasons for groove pancreatitis is caused by the leakage of pancreatic juice into the space between the pancreatic head, descending duodenum, and common bile duct. Endoscopic drainage of Santorini's duct (SD) via the minor papilla is reportedly efficacious but can be difficult due to duodenal stenosis. We report Santorini's duct drainage using endoscopic ultrasonography‐guided pancreaticogastrostomy (EUS‐PGS) for a case of groove pancreatitis with gastric outlet obstruction. Gastric outlet obstruction was improved after 7 months of EUS‐PGS with internal drainage through the Santorini's duct/minor papilla. EUS‐PGS may be effective for treating groove pancreatitis with duodenal stenosis. This is the first report of groove pancreatitis with duodenal stenosis, the symptoms of which were improved by EUS‐PGS.
Role of oxide support in electrocatalytic nitrate reduction on Cu
Authors: Carvalho O. Quinn , Jones Sophia R. S. , Berninghaus Ashley E. , Hilliard Richard F. , Radniecki Tyler S. , Stoerzinger Kelsey A. 
Published: November 2022

AbstractThe electrochemical nitrate reduction reaction (NO3RR) has the potential for distributed water treatment and renewable chemical synthesis. Cu is an active monometallic electrocatalyst for the NO3RR in acidic and alkaline electrolytes, where activity is limited by the reduction of adsorbed nitrate to nitrite. Oxygen‐vacancy forming metal‐oxide supports provide sites for N‐O bond activation in thermal reduction, impacting product distribution as well. Here we compare the electrochemical NO3RR activity of Cu deposited on two metal‐oxide supports (cerium dioxide [Cu/CeO2‐δ] and fluorine‐doped tin dioxide [Cu/FTO]) to a Cu foil benchmark. Considering activity in phosphate‐buffered neutral media, nitrate and adsorbed hydrogen compete for surface sites under NO3RR conditions. The less‐cathodic overpotential on Cu/CeO2‐δ compared to Cu/FTO is attributed to stronger nitrate adsorption, similar to thermal nitrate reduction. Utilization of CeO2‐δ as an electrocatalyst support slightly shifting product distribution toward more oxidized products, either by enhancing nitrate affinity or by a more dynamic process involving the formation and healing of oxygen vacancies (𝑣O••). These results suggest supporting catalysts on metal oxides may enhance activity by promoting the adsorption of anionic reactants on cathodic electrocatalysts.
Modeling and optimization of NO emission for a steam power plant by data‐driven methods
Authors: Movahed Paria , Rezazadeh Ali Akbar , Avami Akram , Soleymani Baghshah Mahdieh , Mashayekhi Mojtaba 
Published: November 2022

AbstractThe evolution of the power industry toward large‐scale automation and self‐monitoring provides the opportunity to optimize the technical and environmental performance of the plant with data‐driven methods with little changes in infrastructure. This article applies the artificial neural network (ANN) and genetic algorithm (GA) to predicting and optimizing NO emissions. Multiple linear regression models, correlation matrix, and research background are employed to find the most influential input features. The generated power, natural gas flow, the flow of gas recirculation fan, gas air heater temperature, and the amounts of oxygen in the stack are identified as the effective input features. Mean Square Error (MSE) and the coefficient of determination (R2) of best architecture (22 neurons in a hidden layer) are calculated 0.0117 and 0.96651, respectively. The Average Percentage Error (APE) is usually below 10%, meaning the model is in good agreement with real data. Finally, the Genetic Algorithm (GA) is used to minimize the amount of NO emissions. The ANN‐GA techniques reduce the NO emission by at least 32% for selected records, enabling us to optimally find the prominent features affecting NO emission by the operational conditions and low economic costs.
Effect of biochar and attapulgite amendment on saline soil hydraulic parameters and shrinkage
Authors: Wu Keqian , Zhao Wenju , Ma Feng , Ma Hong , Cao Wei 
Published: November 2022

AbstractSaline soil reduces soil productivity and exacerbates food security problem. Therefore, it is increasingly necessary to find sustainable farming practices for soil and water conservation. In this regard, conditioning the soil with biochar (BC) or attapulgite (ATP) has been proved as a feasible method of improving water conservation and soil hydraulic characteristics. However, the interactive effect of BC and ATP on saline soil is still unclear. The objective of this study was to investigate the effect of BC and/or ATP on water retention, pore size distribution, hydraulic characteristic parameter, and shrinkage strain of saline soil through laboratory trials. For this purpose, BC and/or ATP were added to the loam soil at three levels of 0%, 2%, and 4% by weight, and saturated in the sodium chloride solution with a concentration of 5 g L−1. Results showed that the Van Genuchten model accurately fitted the obtained soil water characteristic curve (R2 > 0.99). BC and/or ATP amendments increased saline soil water retention capacity compared to the unamended soil. Soil water retention capacity increased as the ATP application rate increased. The saturated water content, field water holding capacity, soil microporosity, and soil retention effect of 2%BC combined with 4%ATP were higher than other treatments. BC facilitated the reduction of soil shrinkage, and ATP increased soil shrinkage. Axial shrinkage strain was negatively correlated with the application rate of BC, and positively correlated with ATP. 4%BC combined with 2%ATP had the least shrinkage strain. The present results could serve as a theoretical foundation for soil amendments to improve soil quality.
Challenges in meeting QoS requirements toward 6G wireless networks: A state of the art survey
Authors: Ahmed Rezwana , Mahmood M. R. , Matin Mohammad Abdul 
Published: November 2022

AbstractThe 6G wireless network with its superior capabilities must be considered to accommodate the much more stringent quality of service (QoS) requirements of the numerous emerging applications and services in the future. Attempting to adhere these constraints raise various challenges that are required to be addressed and solved in order to realize the vision of a fully intelligent and automated future society. This article provides the key enabling technologies and future applications for 6G networks followed by a discussion on QoS. It also presents a state‐of‐the‐art survey on the challenges faced while trying to meet the QoS requirements regarding the time latency, throughput, connectivity, packet loss, and bandwidth, together with possible solutions to handle various constraints. A discussion on user satisfaction estimation from QoS analysis is also included. Finally, the article concludes with future research opportunities in meeting the QoS constraints of the 6G network.
Comparative Study of the Effective Properties of 0–3 and Gyroid Triply Periodic Minimal Surface Cement‐Piezocomposites
Authors: Karmakar Saptarshi , Kiran Raj , Vaish Rahul , Chauhan Vishal Singh , Ahmed Samia Ben , Boukhris Imed , Hwang Wonseop , Sung Tae Hyun , Kumar Anuruddh 
Published: November 2022

AbstractIn the present numerical simulation work, effective elastic and piezoelectric properties are calculated and a comparative study is conducted on a cement matrix‐based piezocomposite with 0–3 and gyroid triply periodic minimal surface (TPMS) inclusions. The present study compares the effective properties of different piezoelectric materials having two different types of connectivity of the inclusions namely, 0–3 inclusions where the inclusions are physically separated from each other and are embedded within the matrix and the second one is TPMS inclusions having interpenetrating phase type connectivity. Effective properties are calculated for four different materials at five different volume fractions namely, 10%, 15%, 20%, 25%, and 30% volume fractions of inclusion by volume. In terms of effective properties and direct piezoelectric effect, TPMS piezocomposite is found to perform better compared to 0–3 piezocomposite. Lead‐free piezoelectric material 0.5Ba(Ca0.8Zr0.2)O3 − 0.5(Ba0.7Ca0.3)TiO3 demonstrates better performance compared to all other material inclusions studied. The present study attempts to highlight improved piezoelectric effective properties of lead‐free material‐based piezocomposites with TPMS inclusions.