bluuebunny/crossref_metadata_2025_split huggingface dataset:
Categorical and dimensional brain network-based models of trauma-related dissociative subtypes
Authors: Lebois Lauren A. M. , Kumar Poornima , Palermo Cori A. , Lambros Ashley M. , O’Connor Lauren , Wolff Jonathan D. , Baker Justin T. , Gruber Staci A. , Lewis-Schroeder Nina , Ressler Kerry J. , Robinson Matthew A. , Winternitz Sherry , Nickerson Lisa D. , Kaufman Milissa L. 
Published: May 2022

AbstractBackgroundTrauma-related pathological dissociation is a multidimensional and disabling phenomenon that involves disruptions or discontinuities in psychological functioning. Despite its prevalence, personal and societal burden, dissociation remains underappreciated in clinical practice, and it lacks a synthesized neurobiological model that could place it in context with other common psychiatric symptoms. To identify a nuanced neurobiological model of pathological dissociation, we examined the functional connectivity of three core neurocognitive networks as related to the dimensional dissociation subtypes of depersonalization/derealization and partially-dissociated intrusions, and the diagnostic category of a complex dissociation disorder, dissociative identity disorder (DID).MethodsParticipants were 91 adult women with and without: a history of childhood trauma, current posttraumatic stress disorder (PTSD) and varied levels of pathological dissociation. Participants provided interview and self-report data about pathological dissociation, PTSD symptoms, childhood maltreatment history, and completed a resting-state functional magnetic resonance imaging scan.ResultsAfter controlling for age, childhood maltreatment and PTSD symptom severity, we found that pathological dissociation was associated with hyperconnectivity within central executive, default, and salience networks, and decreased connectivity of central executive and salience networks with other areas. Moreover, we isolated unique connectivity markers linked to depersonalization/derealization, to partially-dissociated intrusions, and to DID.ConclusionsOur work suggests subtypes of pathological dissociation have robust, discernable, and unique functional connectivity signatures. The neural correlates of dissociation may serve as potential targets for treatment engagement to facilitate recovery from PTSD and pathological dissociation. These results underscore dissociation assessment as crucial in clinical and medical care settings.
Recurrent neural network model of human event-related potentials in response to intensity oddball stimulation
Authors: O’Reilly Jamie A. 
Published: May 2022

AbstractThe mismatch negativity (MMN) component of the human event-related potential (ERP) is frequently interpreted as a sensory prediction-error signal. However, there is ambiguity concerning the neurophysiology underlying hypothetical prediction and prediction-error signalling components, and whether these can be dissociated from overlapping obligatory components of the ERP that are sensitive to physical properties of sounds. In the present study, a hierarchical recurrent neural network (RNN) was fitted to ERP data from 38 subjects. After training the model to reproduce ERP waveforms evoked by 80 dB standard and 70 dB deviant stimuli, it was used to simulate a response to 90 dB deviant stimuli. Internal states of the RNN effectively combine to generate synthetic ERPs, where individual hidden units are loosely analogous to population-level sources. Model behaviour was characterised using principal component analysis of stimulus condition, layer, and individual unit responses. Hidden units were categorised according to their temporal response fields, and statistically significant differences among stimulus conditions were observed for amplitudes of units peaking in the 0 to 75 ms (P50), 75 to 125 ms (N1), and 250 to 400 ms (N3) latency ranges, surprisingly not including the measurement window of MMN. The model demonstrated opposite polarity changes in MMN amplitude produced by falling (70 dB) and rising (90 dB) intensity deviant stimuli, consistent with loudness dependence of sensory ERP components. Although perhaps less parsimoniously, these observations could be interpreted within the context of predictive coding theory, as examples of negative and positive prediction errors, respectively.
Leaf-level metabolic changes in response to drought affect daytime CO2emission and isoprenoid synthesis pathways
Authors: Ladd S. Nemiah , Daber L. Erik , Bamberger Ines , Kübert Angelika , Kreuzwieser Jürgen , Purser Gemma , Ingrisch Johannes , Deleeuw Jason , van Haren Joost , Meredith Laura K. , Werner Christiane 
Published: May 2022

AbstractIn the near future, climate change will cause enhanced frequency and/or severity in terrestrial ecosystems, including tropical forests. Drought responses by tropical trees may affect their carbon use, including production of volatile organic compounds (VOCs), with unpredictable implications for carbon cycling and atmospheric chemistry. It remains unclear how metabolic adjustments by mature tropical trees in response to drought will affect their carbon fluxes associated with daytime CO2production and VOC emission. To address this gap, we used position-specific13C-pyruvate labeling to investigate leaf CO2and VOC fluxes from four tropical species before and during a controlled drought in the enclosed rainforest of Biosphere 2. Overall, plants that were more sensitive to drought had greater reductions in daytime CO2production. Although daytime CO2production was always dominated by non-mitochondrial processes, the relative contribution of CO2from the tricarboxylic acid cycle tended to increase under drought. A notable exception was the legume treeClitoria fairchildiana, which had less anabolic CO2production than the other species even under pre-drought conditions, perhaps due to more efficient refixation of CO2and anaplerotic use for amino acid synthesis.C. fairchildianawas also the only species to allocate detectable amounts of13C label to VOCs, and was a major source of VOCs in the Biosphere 2 forest. InC. fairchildianaleaves, our data indicate that intermediates from the mevalonic acid pathway are used to produce the volatile monoterpene trans-β-ocimene, but not isoprene. This apparent crosstalk between the mevalonic acid and methylerythritol phosphate pathways for monoterpene synthesis declined with drought. Finally, although trans-β-ocimene emissions increased under drought, it was increasingly sourced from stored intermediates and notde novosynthesis. Unique metabolic responses of legumes may play a disproportionate role in the overall changes in daytime CO2and VOC fluxes in tropical forests experiencing drought.
Characteristics of admissions for Kawasaki Disease from 1997 to 2012: Lessons from a national database
Authors: Raskin Alexander , Loomba Rohit S. 
Published: May 2022

AbstractA majority of large epidemiologic studies on Kawasaki Disease have come from Asia. There is paucity of data assessing Kawasaki Disease on a national level in the U.S., particularly in terms of hospitalization co-morbidities and cost. This study set forth to analyze data from the Kids’ Inpatient Database from 1997 to 2012. Data were analyzed for age, race, cardiogenic shock, acute kidney injury, liver failure, acute respiratory distress syndrome, arrhythmia, and congenital heart disease. Additionally, multivariate regression analysis was performed to assess the impact of Kawasaki Disease on coronary artery aneurysms, ECMO, length of stay, cost of stay, and mortality. Asian and Pacific Islander children were disproportionally affected by Kawasaki Disease in the U.S (20.8% of Kawasaki Disease admissions vs 3.3% of all other pediatric hospital admissions, p<0.01). Patients hospitalized for Kawasaki Disease had an increased risk of developing coronary artery aneurysms (OR 2,839, 95%CI 2,2985-3,527) and cardiogenic shock (OR 3.42, 95% CI 2.18-5.37). Patients with Kawasaki disease were less likely to have congenital heart disease (OR 0.62, 95%CI 0.55-0.69), arrhythmia (OR 0.31, 95%CI 0.11-0.84), and acute respiratory distress syndrome (OR 0.29, 95%CI 0.19-0.43). Kawasaki disease patients had shorter hospitalization length of stay by 2.59 days (p <0.01) and decreased cost of stay by $5,513 (p <0.01). Kawasaki Disease had lower mortality when compared to all other admissions (OR 0.03, 95%CI 0.01-0.09). No significant differences were found for ECMO, acute kidney injury, or liver failure.
Immunogenicity and reactogenicity of a third dose of BNT162b2 vaccine for COVID-19 after a primary regimen with BBIBP-CorV or BNT162b2 vaccines in Lima, Peru
Authors: Vargas-Herrera Natalia , Fernández-Navarro Manuel , Cabezudo Nestor E , Soto-Becerra Percy , Solís-Sánchez Gilmer , Escobar-Agreda Stefan , Silva-Valencia Javier , Pampa-Espinoza Luis , Bado-Pérez Ricardo , Solari Lely , Araujo-Castillo Roger V 
Published: May 2022

ABSTRACTBackgroundThe administration of a third (booster) dose of COVID-19 vaccines in Peru initially employed the BNT162b2 (Pfizer) mRNA vaccine. The national vaccination program started with healthcare workers (HCW) who received BBIBP-CorV (Sinopharm) vaccine as primary regimen and elderly people previously immunized with BNT162b2. This study evaluated the reactogenicity and immunogenicity of the “booster” dose in these two groups in Lima, Peru.MethodsWe conducted a prospective cohort study, recruiting participants from November to December of 2021 in Lima, Peru. We evaluated immunogenicity and reactogenicity in HCW and elderly patients previously vaccinated with either two doses of BBIBP-CorV (heterologous regimen) or BTN162b2 (homologous regimen). Immunogenicity was measured by anti-SARS-CoV-2 IgG antibody levels immediately before boosting dose and 14 days later. IgG geometric means (GM) and medians were obtained, and modeled using ANCOVA and quantile regressions.ResultsThe GM of IgG levels increased significantly after boosting: from 28.5±5.0 AU/mL up to 486.6±1.2 AU/mL (p<0.001) which corresponds to a 17-fold increase. The heterologous vaccine regimen produced higher GM of post-booster anti-SARS-CoV-2 IgG levels, eliciting a 13% fold increase in the geometric mean ratio (95%CI: 1.02-1.27) and a median difference of 92.3 AU/ml (95%CI: 24.9-159.7). Both were safe and well tolerated. Previous COVID-19 infection was also associated with higher pre and post-booster IgG GM levels.ConclusionAlthough both boosting regimens were highly immunogenic, two doses of BBIBP-CorV boosted with BTN162b2 produced a stronger IgG antibody response than the homologous BNT162b2 regimen in the Peruvian population. Additionally, both regimens were mildly reactogenic and well-tolerated.
Describing COVID-19 Patients During The First Two Months of Paxlovid (Nirmatrelvir/Ritonavir) Initiation in a Large HMO in Israel
Authors: Tene Lilac , Chodick Gabriel , Fallach Noga , Ansari Wajeeha , Distelman-Menachem Tal , Maor Yasmin 
Published: May 2022

AbstractTitleDescribing COVID-19 Patients During The First Two Months of Paxlovid (Nirmatrelvir/Ritonavir) Initiation in a Large HMO in IsraelObjectiveThe objective of this feasibility study was to assess the number of patients that could be included in a future Real World Evidence study, which would be designed to explore the impact of Paxlovid (nirmatrelvir/ritonavir) on patient outcomes and healthcare resource utilization (HCRU). We also intend to assess the comparability of the patients who were treated with Paxlovid versus patients who did not receive the treatment, either because they declined any COVID-19 treatment or were diagnosed with COVID-19 prior to Paxlovid availability.MethodsThis retrospective observational secondary data study used data from the Maccabi Healthcare Services database during the identification period of June 1, 2021, to February 28, 2022. The study population included patients with at least one positive SARS-CoV-2 RT-PCR test, or a formal rapid antigen test for SARS-CoV-2, during the identification period, the date of which also served as the COVID-19 diagnosis date. We then divided the study population into the following cohorts: Pre-Paxlovid Time Period and Paxlovid Time Period, which was further split into Paxlovid Treated and Paxlovid Untreated.ResultsApplication of inclusion and exclusion criteria to the study population rendered 20,284 patients in the Pre-Paxlovid Time Period cohort and 5,542 in the Paxlovid Time Period cohort that were eligible to receive Paxlovid. This resulted in 3,714 in the Paxlovid Treated and 1,810 in the Paxlovid Untreated cohorts.ConclusionsThis RWE feasibility study of patients with a positive test for COVID-19 between June 1, 2021 to February 28, 2022 illustrates potential comparability between cohorts, as described by their demographics and characteristics.
Puberty contributes to adolescent development of fronto-striatal functional connectivity supporting inhibitory control
Authors: Ojha Amar , Parr Ashley C. , Foran Will , Calabro Finnegan J. , Luna Beatriz 
Published: May 2022

AbstractAdolescence is defined by puberty and represents a period characterized by neural circuitry maturation (e.g., fronto-striatal systems) facilitating cognitive improvements. Though studies have characterized age-related changes, the extent to which puberty influences maturation of fronto-striatal networks is less known. Here, we combine two longitudinal datasets to characterize the role of puberty in the development of fronto-striatal resting-state functional connectivity (rsFC) and its relationship to inhibitory control in 106 10-18-year-olds. Beyond age effects, we found that puberty was related to decreases in rsFC between the caudate and the anterior vmPFC, rostral and ventral ACC, and v/dlPFC, as well as with rsFC increases between the dlPFC and nucleus accumbens (NAcc) across males and females. Stronger caudate rsFC with the dlPFC and vlPFC during early puberty was associated with worse inhibitory control and slower correct responses, respectively, whereas by late puberty, stronger vlPFC rsFC with the dorsal striatum was associated with faster correct responses. Taken together, our findings suggest that certain fronto-striatal connections are associated with pubertal maturation beyond age effects, which, in turn are related to inhibitory control. We discuss implications of puberty-related fronto-striatal maturation to further our understanding of pubertal effects related to adolescent cognitive and affective neurodevelopment.
Modeling the kinetics of amyloid beta pores and long-term evolution of their Ca2+ toxicity
Authors: Shah Syed Islamuddin , Demuro Angelo , Ullah Ghanim 
Published: May 2022

AbstractThe formation of cation-permeable pores due to amyloid beta (Aβ) in the plasma membrane (PM) and membranes of intracellular organelles has been shown to cause disruption of Ca2+ homeostasis in Alzheimer’s disease, leading to neuronal malfunction and degeneration. However, detailed information about the formation, function, and time-evolution of Aβ pores are still lacking. Here we present a comprehensive analysis to show that the Ca2+ toxicity of PM pores formed by Aβ42 progressively increases over the duration of the experiments that last for more than an hour. This mainly results from a progressively increasing number of pores and activity of individual pores having higher open probability (Po) and Ca2+ conductance. To gain deeper insight into the function and evolution of Aβ42 pores and establish their role in Ca2+ toxicity beyond experimental times scales, we developed a data-driven computational model that not only mimics the kinetics of these pores at a given time but also tracks their time-evolution over many hours. Our model suggests that the rising toxicity of Aβ42 pores over time is a combined result of the large number of short-lived pores with low Ca2+ conductance and long-lived higher-conductance pores but fewer in number. Analysis and modeling of the voltage-dependent data show that Aβ42 pores are most active when the cell’s membrane potential is near resting values, making the cell at rest especially more prone to Ca2+ disruptions.
The changing epidemiology of shigellosis in Australia, 2001-2019
Authors: Ibrahim Aaliya , Glass Kathryn , Williamson Deborah A , Polkinghorne Ben , Ingle Danielle J , Wright Rose , Kirk Martyn D 
Published: May 2022

AbstractShigellosis is an increasing cause of gastroenteritis in Australia, including prolonged outbreaks in remote Aboriginal and Torres Strait Islander (hereafter “First Nations”) communities and among men who have sex with men (MSM) in major cities. To determine associations between Shigella species and demographic and geographic factors we used negative binomial regression to analyse national case notifications of shigellosis from 2001 to 2019.S. sonnei and S. flexneri accounted for 42% and 29% of cases, respectively. Nationally, notification rates increased from 2001 to 2019 with yearly incidence rate ratios of 1.04 (95% CI 1.02-1.07) for S. boydii, 1.05 (95% CI 1.04-1.06) for S. sonnei and 1.04 (95% CI 1.04-1.06) for S. flexneri. Children aged 0-4 years had the highest burden of infection for S. flexneri, S. sonnei and S. boydii; and males had a higher notification rate for S. sonnei (incidence rate ratio 1.24, 95% CI 1.15-1.33), reflecting transmission among MSM. First Nations Australians were disproportionately affected by shigellosis, with the notification rate in this population peaking in 2018 at 92.1 cases per 100,000. The findings of this study provide important insights into the epidemiological characteristics of shigellosis in Australia, and can be used to inform targeted public health prevention and control strategies.
Cyberloafing at the workplace: effect of Zhong-Yong thinking on mental health and mindfulness as a moderating role
Authors: Liu Liping , Zhang Chunyu 
Published: May 2022

Purpose
This study aims to integrate conservation of resources theory discus the antecedents and consequences of cyberloafing as well as the boundary effect between cyberloafing and mental health.

Design/methodology/approach
The authors collected 431 valid questionnaires in four months. Each questionnaire was divided into two parts that had to be distributed. The interval between the first distribution and the second distribution was 15 days.

Findings
The research study revealed that employees’ Zhong-Yong thinking and cyberloafing promote mental health, and cyberloafing has a mediating effect. Mindfulness weakens the positive impact of cyberloafing on mental health.

Originality/value
The research study’s results break the stereotype that cyberloafing is not good for organizations. When managers allow employees to engage in cyberloafing at work, this is conducive to employees’ mental health, which can ensure the company’s sustainable development.
Exploring the influence of dimensions of workplace spirituality on innovative work behaviour: role of sense of God
Authors: Saxena Anubhuti , Prasad Asha 
Published: May 2022

Purpose
This study aims to identify the various dimensions of workplace spirituality (WPS) and determine whether these dimensions act as predictors of innovative work behaviour (IWB) among bank employees. This study also aims at studying the moderating role played by sense of God (SOG) between WPS and IWB.

Design/methodology/approach
The methodology involved both qualitative and quantitative approaches. This study was carried out in two phases. Item generation, questionnaire development and exploratory factor analysis (EFA) were conducted in phase 1. Confirmatory factor analysis (CFA) was conducted in phase 2. Seven WPS dimensions originated through EFA, which got validated through CFA later. Structural equation modelling was used for hypotheses testing. To explore the proposed relationships, cross-sectional survey was done on a sample of bank employees from public, private and foreign banks.

Findings
The findings reveal that WPS is a seven-factor construct and affects the IWB of bank employees. The results indicated that four dimensions of WPS significantly increase IWB, and that SOG moderates the relationship between WPS and IWB.

Research limitations/implications
With increasing globalization, there is a growing concern as to whether Indian employers would be able to meet employees’ spiritual needs. Indians tend to have high inclination towards God; through their religious associations, they try to develop a sense of spiritualism. Awareness about the effect of SOG and also the dimensions of WPS on IWB will help organizations in designing effective interventions for making employees more innovative.

Originality/value
The authors believe that the empirical studies testing the consequences of WPS on IWB in the banking industry are limited; also, SOG’s role as a moderator remains unexplored; thus, this study is an attempt to fill the gaps.
Testing the stress‐strain‐outcome model in Philippines‐based call centers
Authors: Jabutay Felicito Angeles , Suwandee Sasithorn , Jabutay Jerwin Angeles 
Published: May 2022

Purpose
The purpose of this paper is to examine the relationships between perceived customer unfriendliness, emotional exhaustion, emotional dissonance and turnover intent using the stress–strain–outcome model in the call center industry in the Philippines. In addition, this paper also investigates the mediating effects of leader–member exchange (LMX) and emotional exhaustion.

Design/methodology/approach
This paper proposed a theoretical model hypothesizing the linkages between the abovementioned variables. Structural equation modeling was used to test the hypotheses using a data set from a sample of 605 Filipino call service representatives.

Findings
The results indicate that perceived customer unfriendliness as a stressor is a positive predictor of emotional exhaustion and emotional dissonance as strains. In turn, emotional exhaustion and emotional dissonance positively influence turnover intent. The results also reveal that LMX mediates the impact of perceived customer unfriendliness on emotional exhaustion. Further, the exhaustion variable mediates the effect of emotional dissonance on turnover intent.

Practical implications
The results suggest that contact with unfriendly customers has negative emotional implications and highlight the need for training or intervention programs to help service agents develop coping mechanisms. The results also imply that leader-initiated high-quality LMX could help attenuate perceived customer unfriendliness's impact on emotional exhaustion.

Originality/value
To the best of the authors’ knowledge,this paper is the first to examine and confirm the causal relationships of the proposed model’s variables using the stress–strain–outcome model.