bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circ_0000658 knockdown inhibits epithelial-mesenchymal transition in bladder cancer via miR-498-induced HMGA2 downregulation
Authors: Qiu Feng , Liu Qiuchen , Xia Yanfu , Jin Hengxi , Lin Yuxin , Zhao Xiaojun 
Published: January 2022

Abstract
Background
Epithelial-mesenchymal transition (EMT) has been associated with the angiogenesis and oncogenic phenotypes of multiple malignant tumors including bladder cancer (BCa). Circular RNAs (circRNAs) are recognized as crucial regulators in the EMT. This study aims to illustrate the possible role of circular RNA_0000658 (circ_0000658) in BCa and the underlying molecular mechanism.

Methods
The expression of circ_0000658, microRNA (miR)-498, and high mobility group AT-hook 2 (HMGA2) was assessed in cancer and adjacent normal tissue collected from BCa patients and human BCa cell lines (MGH-U3, T24, 5637 and SW780). BCa cells were transduced with a series of overexpression or shRNA plasmids to clarify the function of circ_0000658 and miR-498 on the oncogenic phenotypes and EMT of BCa cells. Further, we established nude mice xenografted with BCa cells to validate the roles of circ_0000658 on tumor growth in vivo.

Results
Circ_0000658 was highly expressed in BCa tissue samples and cell lines, which indicated a poor prognosis of BCa patients. Circ_0000658 competitively bound to miR-498 and thus restricted miR-498 expression. Meanwhile, circ_0000658 weakened the binding of miR-498 to the target gene HMGA2 and upregulated the HMGA2 expression. Circ_0000658 elevation or miR-498 knockdown augmented oncogenic phenotypes and EMT of BCa cells, corresponding to a reduction in the expression of β-catenin and E-cadherin as well as an increase in the expression of N-cadherin, Slug, Snail, ZEB1 and Twist. Inhibition of HMGA2 reversed the effects of circ_0000658 overexpression on tumor growth in vivo.

Conclusion
Altogether, our study uncovered the tumor-promoting role of circ_0000658 in BCa via the miR-498/HMGA2 axis.
Infinitely many solutions for the discrete Schrödinger equations with a nonlocal term
Authors: Xie Qilin , Xiao Huafeng 
Published: January 2022

AbstractIn the present paper, we consider the following discrete Schrödinger equations $$ - \biggl(a+b\sum_{k\in \mathbf{Z}} \vert \Delta u_{k-1} \vert ^{2} \biggr) \Delta ^{2} u_{k-1}+ V_{k}u_{k}=f_{k}(u_{k}) \quad k\in \mathbf{Z}, $$
−

(
a
+
b

∑

k
∈
Z

|
Δ

u

k
−
1

|
2

)

Δ
2

u

k
−
1

+

V
k

u
k

=

f
k

(

u
k

)

k
∈
Z
,
where a, b are two positive constants and $V=\{V_{k}\}$
V
=
{

V
k

}
is a positive potential. $\Delta u_{k-1}=u_{k}-u_{k-1}$
Δ

u

k
−
1

=

u
k

−

u

k
−
1

and $\Delta ^{2}=\Delta (\Delta )$

Δ
2

=
Δ
(
Δ
)
is the one-dimensional discrete Laplacian operator. Infinitely many high-energy solutions are obtained by the Symmetric Mountain Pass Theorem when the nonlinearities $\{f_{k}\}$
{

f
k

}
satisfy 4-superlinear growth conditions. Moreover, if the nonlinearities are sublinear at infinity, we obtain infinitely many small solutions by the new version of the Symmetric Mountain Pass Theorem of Kajikiya.
Solutions for a category of singular nonlinear fractional differential equations subject to integral boundary conditions
Authors: Yan Debao 
Published: January 2022

AbstractWe concentrate on a category of singular boundary value problems of fractional differential equations with integral boundary conditions, in which the nonlinear function f is singular at $t=0$
t
=
0
, 1. We use Banach’s fixed-point theorem and Hölder’s inequality to verify the existence and uniqueness of a solution. Moreover, also we prove the existence of solutions by Krasnoselskii’s and Schaefer’s fixed point theorems.
Foresight: a new approach based on the Z-number cognitive map
Authors: Izadi Mostafa , Seiti Hamidreza , Jafarian Mostafa 
Published: January 2022

AbstractForesight has recently emerged as one of the most attractive and practical fields of study, while being used to draw up a preferable future and formulate appropriate strategies for achieving predetermined goals. The present research aimed at providing a framework for foresight with a primary focus on the role of a cognitive approach and its combination with the concept of fuzzy cognitive map in the environments of uncertainty and ambiguity. The proposed framework consisted of the 3 phases: pre-foresight, foresight, and post-foresight. The main stage (foresight) focused on the role of imagination and intuition in drawing the future in the experts’ minds and depicting their perceptions above perceptions in the form of a fuzzy cognitive map influenced by variables related to the subject under study in order to determine a preferable future. The use of a Z-number concept and integrating it with fuzzy cognitive maps in the foresight-oriented decision-making space, which was mainly saturated with uncertainty and ambiguity, was one of the main strengths of the proposed framework in the current investigation. The present paper focused primarily on the evolution of expert’s knowledge with regard to the topic of foresight. The role of Z-number in various processes, from data collection to illustration, analysis, and aggregation of cognitive maps, was considered for gaining knowledge and understanding into the nature of future. Moreover, an ultimate objective was realized through identifying, aggregating, and selecting the variables from each expert’s perspective and then the relationship between each variable was determined in the main stage of foresight. Finally, the proposed framework was presented and explicated in the form of a case study, which revealed satisfactory results.
The novel epiligament theory: differences in healing failure between the medial collateral and anterior cruciate ligaments
Authors: Georgiev Georgi P. , Telang Manasi , Landzhov Boycho , Olewnik Łukasz , Slavchev Svetoslav A. , LaPrade Robert F. , Ruzik Kacper , Tubbs R. Shane 
Published: January 2022

AbstractAccording to current literature, 90% of knee ligament injuries involve the medial collateral ligament or the anterior cruciate ligament. In contrast to the medial collateral ligament, which regenerates relatively well, the anterior cruciate ligament demonstrates compromised healing. In the past, there were numerous studies in animal models that examined the healing process of these ligaments, and different explanations were established. Although the healing of these ligaments has been largely investigated and different theories exist, unanswered questions persist.Therefore, the aim of this article is 1) to review the different historical aspects of healing of the medial collateral ligament and present the theories for healing failure of the anterior cruciate ligament; 2) to examine the novel epiligament theory explaining the medial collateral ligament healing process and failure of anterior cruciate ligament healing; and 3) to discuss why the enveloping tissue microstructure of the aforementioned ligaments needs to be examined in future studies.We believe that knowledge of the novel epiligament theory will lead to a better understanding of the normal healing process for implementing optimal treatments, as well as a more holistic explanation for anterior cruciate ligament healing failure.
Predictive Value of Technical Throwing Skills on Nomination Status in Youth and Long-Term Career Attainment in Handball
Authors: Koopmann Till , Lath Franziska , Büsch Dirk , Schorer Jörg 
Published: January 2022

Abstract
Background
Research on talent in sports aims to identify predictors of future performance. This study retrospectively investigated 1) relationships between young handball field players’ technical throwing skills and (a) their potential nomination to youth national teams and (b) their long-term career attainment 10 years later, and 2) associations between nomination status and career attainment.

Results
Results from retrospectively predicting nomination status and career attainment using logistic regression analyses show that technical throwing skills were partly able to explain players’ nomination status (Nagelkerke R2: females 9.2%, males 13.1%) and career attainment (Nagelkerke R2: 9.8% for female players). Here, variables throwing velocity and time on exercise showed statistically significant effects. In addition, nomination status and career attainment were shown to be associated using chi-square tests (w of .37 and .23 for female and male players, respectively) and nomination status as a predictor increased the prediction of career attainment remarkably (Nagelkerke R2: females 20.3%, males 12.7%).

Conclusions
Given these results, basic technical throwing skills may serve rather as a prerequisite in this age group on national level, emphasizing its importance already on lower levels and in younger age groups. Furthermore, advantages from entering the national TID system early especially for females are discussed.
Beyond race?
Authors: Saharso Sawitri , Scharrer Tabea 
Published: January 2022

AbstractWhile at the moment the world seems to be divided along racial lines and ‘race’ appears to be a central axe of social inclusion and exclusion, in this article we ask whether it is thinkable to go ‘beyond race’. We want to explore the idea of going ‘beyond race’ in four different ways: (1) ‘Beyond race’ as a demographic reality when people of mixed origin form the majority of population; (2) ‘Beyond race’ in regard to policies that aim at combatting inequalities also along color lines, yet are no longer dependent on a notion of race. (3) ‘Beyond race’ in terms of political mobilizations, e.g. the possibility or desirability of anti-racist movements not grounded in identity politics and (4) ‘Beyond race’ as a conceptualization of race that is decoupling biology and culture, or even to stop thinking in racial categories altogether, yet without de-politicizing any marginalised group’s, history and experience. We are aware that this questioning of race, and by implication of ethnicity, may be a typical hang-up of two authors based in Europe. We have invited authors from different parts of the world, and with different academic backgrounds to reflect in a commentary on the issues we raise and to explain their position.
Elderly suicides in Denizli, Turkey: a retrospective study from 2011 to 2020
Authors: Zeybek Volkan , Yetiş Hasan , İzci Abdülkadir , Acar Kemalettin 
Published: January 2022

Abstract
Background
Although suicide rates and methods used may vary according to society, gender, and age there are epidemiological studies reporting that suicide rates increase with advanced age in all societies, particularly accelerating after the age of 65 years. This study aimed to investigate the demographic data and suicide characteristics—such as the location and method, among others—of the elderly suicide deaths among forensic deaths between 2011 and 2020 in Denizli, Turkey.

Results
It was determined that elderly suicides constituted 13.8% of all suicides and increased gradually over the years during the 10-year period. The vast majority of cases were male (82%). It has been observed that hanging is the most frequently used method. It is also noteworthy that although firearm suicide among men was the second most common method, women do not choose this method at all. The majority of elderly suicides (88.5%) in Denizli occurred in the home and its annexes.

Conclusions
Suicide prevention programmes should promote the elderly to benefit widely from social and health services. Therefore, there is a need to include widespread home care services and firearms regulations in prevention programmes.
Using retinal electrophysiology toward precision psychiatry
Authors: Schwitzer Thomas , Leboyer Marion , Laprévote Vincent , Louis Dorr Valérie , Schwan Raymund 
Published: January 2022

AbstractPrecision medicine in psychiatry is based on the identification of homogeneous subgroups of patients with the help of biosignatures—sets of biomarkers—in order to enhance diagnosis, stratification of patients, prognosis, evaluation, and prediction of treatment response. Within the broad domain of biomarker discovery, we propose retinal electrophysiology as a tool for identification of biosignatures. The retina is a window to the brain and provides an indirect access to brain functioning in psychiatric disorders. The retina is organized in layers of specialized neurons which share similar functional properties with brain neurons. The functioning of these neurons can be evaluated by electrophysiological techniques named electroretinogram (ERG). Since the study of retinal functioning gives a unique opportunity to have an indirect access to brain neurons, retinal dysfunctions observed in psychiatric disorders inform on brain abnormalities. Up to now, retinal dysfunctions observed in psychiatric disorders provide indicators for diagnosis, identification of subgroups of patients, prognosis, evaluation, and prediction of treatment response. The use of signal processing and machine learning applied on ERG data enhances retinal markers extraction, thus providing robust, reproducible, and reliable retinal electrophysiological markers to identify biosignatures in precision psychiatry. We propose that retinal electrophysiology may be considered as a new approach in the domain of electrophysiology and could now be added to the routine evaluations in psychiatric disorders. Retinal electrophysiology may provide, in combination with other approaches and techniques, sets of biomarkers to produce biosignatures in mental health.
Ibrutinib in Combination With Rituximab for Indolent Clinical Forms of Mantle Cell Lymphoma (IMCL-2015): A Multicenter, Open-Label, Single-Arm, Phase II Trial
Authors: Giné Eva , de la Cruz Fátima , Jiménez Ubieto Ana , López Jimenez Javier , Martín García-Sancho Alejandro , Terol M. José , González Barca Eva , Casanova María , de la Fuente Adolfo , Marín-Niebla Ana , Muntañola Ana , González-López Tomás José , Aymerich Marta , Setoain Xavier , Cortés-Romera Montserrat , Rotger Amanda , Rodríguez Sonia , Medina Herrera Alejandro , García Sanz Ramón , Nadeu Ferran , Beà Silvia , Campo Elías , López-Guillermo Armando 
Published: January 2022

PURPOSE The need for an individualized management of indolent clinical forms in mantle cell lymphoma (MCL) is increasingly recognized. We hypothesized that a tailored treatment with ibrutinib in combination with rituximab (IR) could obtain significant responses in these patients. METHODS This is a multicenter single-arm, open-label, phase II study with a two-stage design conducted in 12 Spanish GELTAMO sites (ClinicalTrials.gov identifier: NCT02682641 ). Previously untreated MCL patients with indolent clinical forms defined by the following criteria were eligible: no disease-related symptoms, nonblastoid variants, Ki-67 < 30%, and largest tumor diameter ≤ 3 cm. Both leukemic non-nodal and nodal subtypes were recruited. Patients received ibrutinib 560 mg once daily and a total of eight doses of rituximab 375 mg/m2. Ibrutinib could be discontinued after 2 years in the case of sustained undetectable minimal residual disease (MRD). The primary end point was the complete response (CR) rate achieved after 12 cycles according to Lugano criteria. RESULTS Fifty patients with MCL (male 66%; median age 65 years) were enrolled. After 12 cycles of treatment, 42 (84%; 95% CI, 74 to 94) patients had an overall response, including 40 (80%; 95% CI, 69 to 91) with CR. Moreover, undetectable MRD in peripheral blood was achieved in 87% (95% CI, 77 to 97) of cases. At 2 years, 24 of 35 evaluable patients (69%) could discontinue ibrutinib because of undetectable MRD. Four patients had disease progression; three were non-nodal MCL and carried high genomic complexity and TP53 mutations at enrollment. No unexpected toxicity was seen except one patient with severe aplastic anemia. CONCLUSION Frontline IR combination achieves a high rate of CRs and undetectable MRD in indolent clinical forms of MCL. Discontinuation seems appropriate in cases with undetectable MRD, except for TP53-mutated cases.
Intractable Seizures and Limbic Encephalitis, Unaccounted Complications of Type 1 Diabetes Autoimmunity
Authors: Madkhali Mohammed A , Hao Jenifer-Kris , Khan Mohammad Saud , Himani Sharma , Jaume Alexa , Tiwari Abhinav , Imam Shahnawaz , Jaume Juan Carlos 
Published: January 2022

Abstract
Glutamic acid decarboxylase 65kD autoantibody (GAD65Ab) is frequently detected in patients with refractory epilepsy and stiff person syndrome. In contrast to T1D, the pathological role of GAD65Ab in neurological disorders is still debatable. As a result, the implementation of possible immunotherapy is usually delayed. This report presents 2 cases of GAD65Ab-associated brain autoimmunity and their different management. We present clinical data and discuss management based on available evidence in the reviewed literature. Both cases presented with acute on chronic neurological symptoms and were GAD65Ab positive. Case 1, a 30-year-old man with a history of early-onset type 1 diabetes mellitus at 14 months, followed by cryptogenic temporal epilepsy at 11 years of age, presented with intractable seizures. Case 2, a 48-year-old woman, presented with a history of recurrent severe headaches, cognitive impairment, decreased memory, and behavioral symptoms. GAD65Ab was detected in both patients’ sera. Cerebrospinal fluid GAD65Ab was only checked and positive in case 1. Case 2 was diagnosed with limbic encephalitis, treated with immunotherapy, and showed a remarkable clinical improvement. Case 1 with refractory epilepsy failed multiple antiepileptic drugs and responsive-stimulator system treatments. He was finally diagnosed with autoimmune epilepsy. The delay in diagnosis resulted in a lost opportunity for early immunotherapy. In conclusion, autoantibody screening and early initiation of immunotherapy should be considered to manage GAD65Ab-associated neurological disorders.
Running Mascara: The Hermeneutics of Trans Visual Archives in Late Franco-Era Spain
Authors: Fernández Galeano Javier 
Published: January 2022

Abstract
This article traces the curation of visual archives of trans subjectivity by the Franco regime. It focuses specifically on the experiences of three trans women who were prosecuted in the early to mid-1970s. Based on the definition of photographs as “material performances,” the author reconsiders recent debates about the “ethics of turning away” from forensic documents. Since Spanish privacy laws forbid the full reproduction of defendants’ photographs, this study also delves into the ethics of research on trans visibility in contexts of criminalization. The examined evidence demonstrates the disproportionate targeting of poor trans women as well as the centrality of the paseo (stroll) in their daily struggle for belonging. The confiscated photographs show a community of trans women posing in natural or public settings using different techniques to highlight the eroticism of their bodies. Likewise, trans women’s representational strategies centered joy, sisterhood, and intimacy as tenets of a livable life.
From the Law of Value Debate to the One-Child Policy in China: On Accounting and Biopolitics
Authors: Thompson Malcolm 
Published: January 2022

AbstractThis article argues that the origins of the one-child policy beginning in 1980 in China, and its development into the current system of “comprehensive population management,” are to be found not in any unfolding of a statist or authoritarian logic, or within the parameters of a nominally “socialist” project, but rather in a return to a properly capitalist set of concerns and governmental techniques, the first iteration of which can be traced to the 1920s and 1930s. With regard to the broad set of economic reforms launched in the period 1979–81, it is argued that the one-child policy is absolutely continuous with other reforms across economic sectors (agricultural responsibility systems and urban enterprise reforms) and discontinuous with anything we might understand as population management in the period 1949–76. The “law of value debate” in 1979, which “resolved” a long-standing set of issues concerning national accounting, planning, and accumulation, is found to be—despite its apparently Marxist character, derivation, and vocabulary—the passage through which a capitalist developmental logic was reintroduced into Chinese governing, with significant consequences.
Thinking Like a State: Policing Dangerous Thought in Imperial Japan, 1900–1945
Authors: Ward Max 
Published: January 2022

AbstractThis article explores the changing ways the Japanese police understood and policed radical politics between 1900 and 1945. Specifically, it traces the process in which the objective of policing transformed from an emphasis on political organizations, their activities, publications, and assemblies in the 1900s to the policing of individuals ostensibly harboring “dangerous ideas” that were deemed threatening to state and capital—what the police came to categorize as “thought crime” by the late 1920s. Once “thought” was identified as an object for policing, Japanese police agencies began to practice a kind of intellectual history—thinking like a state—to distinguish dangerous thought and to understand its origin and its spread during the socioeconomic turbulence of the interwar period. Drawing on Jacques Rancière’s theory of police, this article explores how police manuals and other publications categorized certain ideas, texts, enunciations, and slogans and distributed them based on the presumed degree of danger they posed to the imperial polity. It reveals how the expanded classifications and distributions of dangerous thought transformed policing in the 1920s, thereby extending imperial state power into various aspects of social life in interwar Japan.
Early Minimally Invasive Parafascicular Surgery for Evacuation of Spontaneous Intracerebral Hemorrhage in the Setting of Computed Tomography Angiography Spot Sign: A Case Series
Authors: Falcone Joseph , Chen Jefferson W. 
Published: January 2022

BACKGROUND:
Spontaneous intracerebral hemorrhage (sICH) is associated with high morbidity and mortality, and the role of surgery is uncertain. Spot sign on computed tomography angiography (CTA) has previously been seen as a contraindication for minimally invasive techniques.

OBJECTIVE:
To demonstrate the use of minimally invasive parafascicular surgery (MIPS) for early evacuation of sICH in patients with spot sign on CTA.

METHODS:
Retrospective review of patients presenting to a US tertiary academic medical center from 2018 to 2020 with sICH and CTA spot sign who were treated with MIPS within 6 h of arrival.

RESULTS:
Seven patients (6 men and 1 woman, mean age 54.4 yr) were included in this study. There was a significant decrease between preoperative and postoperative intracerebral hemorrhage volumes (75.03 ± 39.00 cm3 vs 19.48 ± 17.81 cm3, P = .005) and intracerebral hemorrhage score (3.1 ± 0.9 vs 1.9 ± 0.9, P = .020). The mean time from arrival to surgery was 3.72 h (±1.22 h). The mean percentage of hematoma evacuation was 73.78% (±21.11%). The in-hospital mortality was 14.29%, and the mean modified Rankin score at discharge was 4.6 (±1.3). No complications related to the surgery were encountered in any of the cases, with no abnormal intraoperative bleeding and no pathology demonstrating occult vascular lesion.

CONCLUSION:
Early intervention with MIPS appears to be a safe and effective means of hematoma evacuation despite the presence of CTA spot sign, and this finding should not delay early intervention when indicated. Intraoperative hemostasis may be facilitated by the direct visualization provided by a tubular retractor system.