bluuebunny/crossref_metadata_2025_split huggingface dataset:
African Honey Bee: What You Need to Know
Authors: Hall H. Glenn , Zettel-Nalen Catherine , Ellis James D. 
Published: October 2022

African honey bees entered the United States in the early 1990s and have since spread throughout the Southwest and Southeast, including parts of Florida. Compared to European bees, African bees are highly aggressive when disturbed and are more likely to sting humans and animals. This revised 6-page fact sheet covers the history and distribution of African honey bees in the Americas and explains how beekeepers and residents can manage their interactions with these bees. Written by H. Glenn Hall, Catherine Zettel-Nalen, and James D. Ellis, and published by the UF Department of Entomology and Nematology, December 2014.
Synthesizing, Studying Molecular Docking, Characterizing, and Preliminary Evaluating Anti-Bacterial Effects of Derivatives of Serotonin Contain Imidazolidine Ring
Authors: Marwa Abdullah Saleh  , Karima Fadhil Ali  , Basma M. Abd Razik  
Published: October 2022

This study included synthesis of new serotonin derivatives in which imidazolidine rings are present in their structures. The final imidazolidine derivatives compounds were synthesized by reaction of synthesized

Schiff bases derivatives of serotonin with the glycine (NH2-CH2COOH) in presence of tetrahydrofuran (THF) as a solvent. The imidazolidine derivatives were identified by physical characteristics, FT-IR spectroscopy and 1H- NMR spectroscopy. Biological activities against two Gram negative (Klebsiella and E. coli) and two Gram positive (Streptococcus pyogenes and Staphylococcus aureus) bacteria were also distinguished. All the synthesized compounds III(a-d) exhibit moderate activities on four types of bacteria comparing with the activity of standard drug (Trimethoprim) but the highest activities of these compounds occur on Streptococcus pyogenes and their least activities occur on E. coli. The synthesized compounds were studied for the molecular docking to know the interaction and affinity of binding between them and bacteria
Analysis of Azithromycin adverse events in COVID-19 Patients reported to Iraqi Pharmacovigilance center in 2020
Authors: Yasir A. Noori  , Inam S. Arif  , Manal M. Younus  , Mohammed M. Mohammed  
Published: October 2022

Azithromycin is an antibiotic that belongs to the macrolide family used in a wide variety of bacterial diseases. However, it has been proposed as a potential therapy for the treatment of SARS-CoV-2 pneumonia (off-label use) given for its antiviral and

immunomodulatory activity. Never-theless, its role in the treatment of COVID-19 remains unclear. Azithromycin has a well-characterized safety profile. However, its use outside the approved indication needs further follow up to ensure that the benefit-risk balance remains positive. One method to look for new/ changed safety information is through using the information component (IC025) value. IC025 is the lower limit of a 95% credibility interval for the IC. The credibility interval provides information about the stability of a particular IC value: the narrower the interval, the higher the stability.
Objective:
Study the submitted adverse events reports of Azithromycin to the Iraqi Pharmacovigilance center and compare the occurrence of these reported adverse events in Iraq to the internationally reported cases during 2020COVID-19 pandemic using IC025.

Methodology:
The reported adverse events of Azithromycin to the national Pharmacovigilance database were studied qualitatively (age, gender and seriousness) and quantitatively (using IC025) as a measure of presence of a new/changed safety information related to Azithromycin.

Results:
The total number of reports for Azithromycin were 419, female represent (43%) and male represent (55.8%), and the predominant age groups was from 45-64 years representing (41.1%). The most widely reported adverse events were gastrointestinal disorders (68%), cardiac disorders (14.1%), general disorders and administration site effect (6.9%), and investigations (Interfere with Lab tests) (5.7%). There were 96 drug-adverse reaction combinations. The IC025 value for the most widely reported adverse events showed a comparable value for ECG-QT prolonged (3.6/3.7), Arrhythmia (0.6/0.7). There was a decreased value for palpitation (0.5/0.9) and dyspnea (0.3/0.6). Tachycardia and increased liver enzymes showed an increased value of (2.0/0.1) and (0.5/0.1) respectively.

Conclusion:
Using the IC025 was helpful in finding the increased reporting rate of adverse events compared to the background rate.
Hirarki Pengaruh Pada Talkshow Kick Andy Double Check Metro TV Program Guiteeres Pahlawan
Authors: Rasyidi Arif , Syahputra Hendra Eka , Suparni Sri 
Published: October 2022

Tujuan riset ini teruntuk mengetahui mekanisme kebijakan yang diterapkan dari pimpinan redaksi sampai dengan berita tersebut ditayangkan sangat memenuhi unsur-unsur yang disampaikan dimulai dari lingkaran paling kecil pada level individu pelaku media, praktik rutinitas, organisasi media, extramedia, sampai dengan level ideologi pada Talkshow “Kick ANDY DOUBLE CHECK” METRO TV. Metode riset ini mempergunakan penelitian kualitatif dengan pendekatan analisis deskriptif dan menggunakan teknik purposive sampling, dengan wawancara tak terstruktur yang mana berupa wawancara yang bebas. Hasil penelitian menunjukkan bahwa pengaruh kepemilikan sebuah media terhadap konten media sangat berpengaruh sama halnya dengan studi kasus program Kick Andy di Metro TV. Sudah jelas bagaimana level-level faktor menggambarkan bagaimana hirarki pengaruh hirarki dalam membuat kebijakan redaksi pada stasiun televisi Metro TV. Dari orientasi personal para pekerja media, profesionalisme, kebijakan perusahaan, pola kepemilikan perusahaan, lingkungan ekonomi, pengiklan sampai dengan pengaruh-pengaruh ideologi. Jadi dari kelima faktor-faktor yang sudah dijelaskan sebelumnya sangat berpengaruh terhadap isi media yang disampaikan
Staging Music in the Aesthetic Regime of Art: Rancière, Berlioz and the Bells of Harold en Italie
Authors: Cachopo João Pedro 
Published: October 2022

Despite their diversity and insight, none of the chapters included in Aisthesis deals directly with music. Hence the relevance of a musical “scene” which the author suggests might well revolve around Berlioz’s Harold en Italie and take as a point of departure a passage from the composer’s Mémoires in which he discusses François-Joseph Fétis’s accusation that the work included a “wrong” note. Examining Berlioz ambivalent response to this accusation, which draws on the rules of harmony, while also winking at the principles of programme music, Cachopo argues that the note’s “noisy” and “grainy” presence proves obsolete the assumption of a purely musical domain.
Dual-fluorescent reporter for live-cell imaging of the ER during DENV infection
Authors: Corliss Lochlain , Holliday Madeline , Lennemann Nicholas J. 
Published: October 2022

Infection by flaviviruses leads to dramatic remodeling of the endoplasmic reticulum (ER). Viral replication occurs within virus-induced vesicular invaginations in the ER membrane. A hallmark of flavivirus infection is expansion of the ER membrane which can be observed at specific time points post infection. However, this process has not been effectively visualized in living cells throughout the course of infection at the single cell resolution. In this study, we developed a plasmid-based reporter system to monitor flavivirus infection and simultaneous virus-induced manipulation of single cells throughout the course of infection in real-time. This system requires viral protease cleavage to release an ER-anchored fluorescent protein infection reporter that is fused to a nuclear localization signal (NLS). This proteolytic cleavage allows for the translocation of the infection reporter signal to the nucleus while an ER-specific fluorescent marker remains localized in the lumen. Thus, the construct allows for the visualization of virus-dependent changes to the ER throughout the course of infection. In this study, we show that our reporter was efficiently cleaved upon the expression of multiple flavivirus proteases, including dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV). We also found that the DENV protease-dependent cleavage of our ER-anchored reporter exhibited more stringent cleavage sequence specificity than what has previously been shown with biochemical assays. Using this system for long term time-lapse imaging of living cells infected with DENV, we observed nuclear translocation of the reporter signal beginning approximately 8 hours post-infection, which continued to increase throughout the time course. Interestingly, we found that increased reporter signal translocation correlated with increased ER signal intensity, suggesting a positive association between DENV infection and ER expansion in a time-dependent manner. Overall, this report demonstrates that the FlavER platform provides a useful tool for monitoring flavivirus infection and simultaneously observing virus-dependent changes to the host cell ER, allowing for study of the temporal nature of virus-host interactions.
Speckle tracking imaging evaluation of left ventricular myocardial work comparing right ventricular septal pacing with His-Purkinje system area pacing
Authors: Meng Qingguo , Li Yao , Wang Sijia , Feng Tianhang , Xu Huijun , Liu Juan , Liu Xuebing , Guo Zhiyu , Deng Yan , Li Chunmei , Tang Yijia , Yin Lixue 
Published: October 2022

AimsWe sought to objectively assess left ventricular myocardial work (MW) parameters after right ventricular septal pacing (VSP) and His-Purkinje system area pacing (HPSAP) procedures.Materials and methodsPatients undergoing double-chamber pacemaker implantation for III-degree atrioventricular block (III° AVB) were assessed 1 year after implantation. VSP and HPSAP groups (20 and 23 patients, respectively) were compared against 40 healthy age-matched volunteers. Two-dimensional ultrasound speckle tracking imaging was used to obtain the global myocardial work index (GWI), global myocardial work efficiency (GWE), global myocardial constructive work (GCW), global myocardial wasted work (GWW), left ventricular stratified strain, and peak strain dispersion (PSD).ResultsGWI, GWE, and GCW parameters were improved in HPSAP compared to VSP, while GWW was significantly larger in the VSP group compared to the HPSAP group (all p &lt; 0.05). HPSAP outperformed the VSP group in comparisons of global left ventricular longitudinal strain and stratified strain. Compared to controls, the GCW of all segmental myocardium (17/17 segments) in the VSP group was significantly reduced, while 70.59% (12/17 segments) in the HPSAP group was lower than the control group. GCW in the left ventricular segment of the HPSAP group was bigger than the VSP group (29.41%; 5/17 segments) and mainly concentrated in the ventricular septum and inferior wall.ConclusionOur findings suggest that HPSAP performance outcomes are improved over VSP after 1 year, especially in left ventricular contractile synchrony, and HPSAP is beneficial to the effective myocardial work of the left ventricle.
Clinical assessment of resting full-cycle ratio and fractional flow reserve for coronary artery disease in a real-world cohort
Authors: Chuang Ming-Ju , Chang Chun-Chin , Lee Yin-Hao , Lu Ya-Wen , Tsai Yi-Lin , Chou Ruey-Hsing , Wu Cheng-Hsueh , Lu Tse-Min , Huang Po-Hsun 
Published: October 2022

BackgroundThere are few reports published on the comparison of the resting full-cycle ratio (RFR) and fractional flow reserve (FFR) on the assessment of the severity of coronary stenosis. We aimed to investigate the diagnostic accuracy of RFR for detection of functionally significant coronary lesions.MethodsThis was an observational, retrospective, single-center study. We evaluated both RFR and FFR for 277 coronary lesions of 235 patients who underwent coronary angiography. Patients presenting with chronic coronary syndrome, unstable angina, or non-ST-elevation myocardial infarction were included.ResultsThe mean FFR and RFR values were 0.84 ± 0.08 and 0.90 ± 0.08, respectively. RFR significantly correlated with FFR (r = 0.727, P &lt; 0.001). The agreement rate between the FFR and RFR was 79.8% (221/277). The diagnostic performance of RFR vs. FFR was accuracy 79.8%, sensitivity 70.4%, specificity 83.7%, positive predictive value 64.0%, and negative predictive value 87.2%. The discriminative power of RFR to identify lesions with FFR ≤ 0.80 was acceptable when the RFR value was within the gray zone [0.86 ≤ RFR ≤ 0.93; AUC: 0.72 (95% CI:0.63–0.81)], while it was excellent when the RFR value was out of the gray zone [RFR &gt; 0.93 or &lt; 0.86; AUC: 0.94 (95% CI:0.88–0.99)].ConclusionRFR was significantly correlated with FFR in the assessment of intermediate coronary stenosis. An RFR-FFR hybrid approach increases the diagnostic accuracy of RFR in the detection of functionally significant lesions.
Characterization of KLH-driven immune responses in clinical studies: A systematic review
Authors: Saghari Mahdi , Jansen Manon A. A. , Grievink Hendrika W. , Rissmann Robert , Moerland Matthijs 
Published: October 2022

The pharmacological activity assessment of novel immunomodulatory drugs in early-stage drug development is challenging as healthy volunteers do not express relevant immune biomarkers. Alternatively, the immune system can be challenged with keyhole limpet hemocyanin (KLH), a suitable antigen for studying adaptive immune responses. This report systemically reviews the KLH challenge in clinical studies focusing on the characterization of the KLH-driven systemic and local immune responses, identification of the KLH-induced biomarkers, and the evaluation of the effect of pharmacological interventions and diseases on the KLH response. A systematic literature review was carried out in PubMed spanning from 1967 to 2022. The systemic humoral KLH responses could be characterized by ELISA after 3 weeks following immunization. For the systemic cellular and molecular immune responses multiple KLH immunizations and the use of novel techniques such as flow cytometry and ELISpot yield optimal results. The objective evaluation of dermal KLH rechallenge allows for more accurate and sensitive quantification of the local response compared to subjective scoring. For the local cellular and molecular assays after KLH dermal rechallenge we also advocate the use of multiple KLH immunizations. Furthermore, oral KLH feeding, age, physical activity, alcohol consumption, stress, as well as certain auto-immune diseases also play a role in the KLH-induced immune response. Importantly, based on the KLH challenges, the effect of (novel) immunomodulatory drugs could be demonstrated in healthy volunteers, providing valuable information for the clinical development of these compounds. This review underlines the value of KLH challenges in clinical studies, but also the need for standardized and well-controlled methodology to induce and evaluate KLH responses.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifierCRD42022335419
A complex patchwork of magma bodies that fed the Bishop Tuff supereruption (Long Valley Caldera, CA, United States): Evidence from matrix glass major and trace-element compositions
Authors: Gualda Guilherme A. R. , Ghiorso Mark S. , Hurst Aaron A. , Allen Madeline C. , Bradshaw Richard W. 
Published: October 2022

The geologic record reveals events in which enormous volumes (100–1000s of km3) of magma were erupted in a matter of days to months. Yet, the architecture of magmatic systems that feed supereruptions can only be investigated through the study of ancient systems. For more than 40 years, the Bishop Tuff (Long Valley, California) has been the archetypal example of a single, zoned magma body that fed a supereruption. Early-erupted material is pyroxene-free and crystal poor (&lt; 20 wt%), presumably erupted from the upper parts of the magma body; late-erupted material is orthopyroxene and clinopyroxene-bearing, commonly more crystal rich (up to 30 wt% crystals), and presumably tapped magma from the lower portions of the magma body. Fe-Ti oxide compositions suggest higher crystallization temperatures for late-erupted magmas (as high as 820°C) than for early-erupted magmas (as low as 700°C). Pressures derived from major-element compositions of glass inclusions were used to suggest an alternative model of lateral juxtaposition of two main magma bodies—each one feeding early-erupted and late-erupted units. Yet, this interpretation has proven controversial. We present a large dataset of matrix glass compositions for 227 pumice clasts that span the stratigraphy of the deposit. We calculate crystallization pressures based on major-element glass compositions using rhyolite-MELTS geobarometry and crystallization temperatures based on Zr in glass using zircon-saturation geothermometry. Additionally, we apply the same methods to 1,538 major-element and 615 trace-element analyses from a dataset from the literature. The results overwhelmingly demonstrate that the variations in crystallization temperature and pressure are not consistent with vertical stratification of a single magma body. All crystallization pressures and temperatures are very similar, with modes of ∼150 MPa and ∼730°C. Our results support lateral juxtaposition of three main magma bodies. Magmas represented by smaller stratigraphic units crystallized at similar pressures as the main bodies, which suggests coexistence of larger and smaller magma bodies at the time of eruption. We compare our findings with results for other very large eruptions and supereruptions. We argue that supereruptions typically mobilize a complex patchwork of magma bodies that reside within specific levels of the crust. These eruptions reveal the architecture of the crust during moments of high abundance of eruptible magma, revealing crustal states that differ from what is inferred for magmatic systems currently present on Earth.
Mw ≥ 5 aftershocks of the 2008 Sichuan earthquake: Analysis of temporal variation of Omori Law p-value
Authors: Gupta Harsh K. , Rekapalli Rajesh 
Published: October 2022

Strong to great earthquakes considerably weaken the structural strength of the subsurface strata and civil constructions. The occurrence of Mw ≥ 5 aftershocks further contributes to the loss of human lives and damage to property. Therefore, the estimate of the duration of such aftershocks occurring near a metropolitan area is of major concern. In a previous study (Gupta et al., 2008), aftershocks for the destructive Sichuan earthquake, China (12 May 2008 Mw 7.9) for 23 days were used to estimatep-value and it was proposed that the M ≥ 5 aftershocks may continue for 7 months. In the present study, we analyze aftershock activity of Mw≥ 5 for 2-year duration within an area of 300 km radius from the epicenter, using modified Omori Law, which is well-known for analyzing aftershock rate and duration. We compare our results with the duration of aftershocks estimated using the exponential scaling law for the M ≥ 5 aftershock duration for major to great Himalayan earthquakes. Our analysis suggests that a highp-value (&gt;1) indicates a slow decay of aftershocks as observed. As thep-value changes with time, the estimates of the duration of the occurrence of aftershocks of M ≥ 5 may change. Using a dynamic approach, the data of the first 100 days has been used in this study and the duration of occurrence of Mw ≥ 5 earthquakes is estimated to be ∼300 days, which is found to be true. Our analysis suggests that the temporal variation of thep-value from the onset of the mainshock and the slope of its variation are the key elements in comprehending the duration of the occurrence of the aftershocks of a certain magnitude. We infer that a highp-value (p&gt;1) after the main earthquake, indicates a longer duration of larger aftershocks, which has been found in the case of the Sichuan earthquake. Thep-value decreases with time, however, an intermittent increase in thep-value could be an indicator of an increased chance for the occurrence of a higher magnitude aftershock. The proposed dynamic approach to estimating temporalp-values may help in forecasting the occurrence of stronger aftershocks more effectively. We believe that this is the first time, where the temporal variation ofp-values is estimated and related to the occurrence of aftershocks.
Discovering hydrothermalism from Afar: In Situ methane instrumentation and change-point detection for decision-making
Authors: Preston Victoria , Flaspohler Genevieve , Kapit Jason , Pardis William , Youngs Sarah , Martocello Donald E. , Roy Nicholas , Girguis Peter R. , Wankel Scott D. , Michel Anna P. M. 
Published: October 2022

Seafloor hydrothermalism plays a critical role in fundamental interactions between geochemical and biological processes in the deep ocean. A significant number of hydrothermal vents are hypothesized to exist, but many of these remain undiscovered due in part to the difficulty of detecting hydrothermalism using standard sensors on rosettes towed in the water column or robotic platforms performing surveys. Here, we use in situ methane sensors to complement standard sensing technology for hydrothermalism discovery and compare sensors on a towed rosette and an autonomous underwater vehicle (AUV) during a 17 km long transect in the Northern Guaymas Basin in the Gulf of California. This transect spatially intersected with a known hydrothermally active venting site. These data show that methane signalled possible hydrothermal-activity 1.5–3 km laterally (100–150 m vertically) from a known vent. Methane as a signal for hydrothermalism performed similarly to standard turbidity sensors (plume detection 2.2–3.3 km from reference source), and more sensitively and clearly than temperature, salinity, and oxygen instruments which readily respond to physical mixing in background seawater. We additionally introduce change-point detection algorithms—streaming cross-correlation and regime identification—as a means of real-time hydrothermalism discovery and discuss related data supervision technologies that could be used in planning, executing, and monitoring explorative surveys for hydrothermalism.