bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efectividad de la suplementación nutricional con polifenoles sobre el daño muscular y marcadores de estrés oxidativo en diferentes tipos de ejercicios físicos: Una revisión de la literatura.
Authors: Donadio Pedro , Muñoz Cristobal , Flores-Lucero Francisca , Garcia-Diaz Diego F. , Farias-Valenzuela Claudio , Quezada Esteban , Poblete-Aro Carlos 
Published: December 2022

During exercise, there is a redox imbalance that increases reactive oxygen species, generating oxidative stress that favors muscle damage, affecting physical and sports performance. Different antioxidant supplements have been used to optimize muscle recovery after physical exercise. However, the effects of various antioxidants have been counterproductive, since the reactive oxygen species generated by exercise are necessary for muscle adaptation and their reduction prevents correct intracellular signaling and consequently the adaptation of skeletal muscle to exercise. Polyphenols are a type of antioxidant that are present in various fruits and herb extracts that have different characteristics depending on their structure and composition, some presenting a cell signaling pathway similar to exercise, generating different stimuli at the skeletal muscle level, being able to reduce the oxidative damage generated by exercise and even being able to enhance its effects. The aim of this literature review is to describe the effect of various polyphenols on muscle damage and biomarkers of oxidative stress on different forms of physical exercise and sports in adults.
Durante la realización de ejercicio, existe un desbalance redox que aumenta las especies reactivas de oxígeno generando un estrés oxidativo que favorece el daño muscular incidiendo en el rendimiento físico y deportivo. Diferentes suplementos antioxidantes han sido utilizados para optimizar la recuperación muscular posterior a la realización de ejercicio físico. Sin embargo, los efectos de diversos antioxidantes han sido contraproducentes, ya que las especies reactivas de oxígeno generadas por el ejercicio son necesarias para la adaptación muscular y la disminución de éstas, impide la correcta señalización intracelular y con esto, la adaptación del músculo esquelético frente al ejercicio físico. Los polifenoles son un tipo de antioxidantes que están presentes en diversos frutos y extractos de hierbas que poseen diversas características dependiendo de su estructura y composición, presentando algunos una ruta de señalización celular similar al ejercicio físico, generando diferentes estímulos a nivel del músculo esquelético, pudiendo reducir el daño oxidativo generado por el ejercicio e incluso, pudiendo potenciar sus efectos. El objetivo de la presente revisión a la literatura es determinar y describir el efecto de diversos polifenoles en el daño muscular y marcadores de estrés oxidativo posterior a diferentes modalidades de ejercicio físico y deportes en adultos.
Multiple Sclerosis and Use of Medical Cannabis: A Retrospective Review of a Neurology Outpatient Population
Authors: Rainka Michelle M. , Aladeen Traci S. , Mattle Anna G. , Lewandowski Emily , Vanini Denis , McCormack Katelyn , Mechtler Laszlo 
Published: December 2022

ABSTRACTBACKGROUNDPatients diagnosed as having multiple sclerosis (MS) experience a wide range of symptoms requiring pharmacologic management, and many do not achieve adequate symptom control. The purpose of this study was to evaluate the role of medical cannabis (MC) as part of a comprehensive treatment plan for patients with MS.METHODSA retrospective medical record review of 141 patients with MS receiving MC for symptom management was conducted. Data were collected for up to 4 follow-up appointments after initiation of MC. Outcomes included changes in MS symptoms, medication changes, adverse events, and changes in cognition and mobility.RESULTSPatients experienced extensive MS symptom improvement after initiation of MC, with alleviation of pain (72% of patients) and spasticity (48% of patients) and improvement in sleep (40% of patients) the most common. There was a significant reduction in concomitant opioid use after initiating MC as evidenced by a significant decrease in daily morphine milligram equivalents among patients prescribed opioid analgesics (P = .01). Decreases in muscle relaxant use and benzodiazepine use did not reach significance (P &gt; .05). The most common adverse reaction to MC was fatigue (11% of patients).CONCLUSIONSIn many patients with MS, MC was well tolerated, eased pain and spasticity, improved sleep and other symptoms, and reduced use of concomitant opioid analgesics. Prospective studies are needed to further investigate the role of MC in the treatment of patients with MS.
Teoría de la complejidad en la atención del paciente con dolor musculoesquelético
Authors: Andreu Mauro , Policastro Pablo , Díias Tatiana , Pardo Yolanda 
Published: December 2022

Los sistemas no lineales no son susceptibles de ser investigados con métodos reduccionistas. En este sentido, la teoría de la complejidad ofrece un enfoque alternativo para cuantificar la importancia de los factores contextuales en el paciente con dolor musculoesquelético. El resultado del uso positivo (placebo) o negativo (nocebo) de factores contextuales en el entorno terapéutico, podría ser responsable de gran parte de un componente inespecífico en la eficacia del tratamiento, afectando directamente la calidad de los resultados relacionados con la salud del paciente (por ejemplo, dolor, funcionalidad o satisfacción).En los últimos años, se ha incrementado la comprensión del valor de estos efectos. A pesar del creciente interés, el conocimiento y el reconocimiento de los efectos terapéuticos, continúan siendo limitados y heterogéneos entre los fisioterapeutas, lo cual reduce su valor traslacional en el campo de la fisioterapia.El propósito de este estudio es presentar el abordaje el paciente con dolor musculoesquelético desde la perspectiva la teoría de la complejidad.
DNA barcoding unveils a high diversity of caddisflies (Trichoptera) in the Mount Halimun Salak National Park (West Java; Indonesia)
Authors: Kilian Isabel C. , Espeland Marianne , Mey Wolfram , Wowor Daisy , Hadiaty Renny K. , von Rintelen Thomas , Herder Fabian 
Published: December 2022

Background
Trichoptera are one of the most diverse groups of freshwater insects worldwide and one of the main bioindicators for freshwater quality. However, in many areas, caddisflies remain understudied due to lack of taxonomic expertise. Meanwhile, globally increasing anthropogenic stress on freshwater streams also threatens Trichoptera diversity.

Methods
To assess the Trichoptera diversity of the area within and around the Mount Halimun Salak National Park (MHSNP or Taman Nasional Gunung Halimun Salak) in West Java (Indonesia), we conducted a molecular-morphological study on Trichoptera diversity using larvae from a benthic survey and adults from hand-netting. In addition to morphological identification, we applied four different molecular taxon delimitation approaches (Generalized Mixed Yule Coalescent, Bayesian Poisson Tree Processes, Automatic Barcode Gap Discovery and Assemble Species by Automatic Partitioning) based on DNA barcoding of Cytochrome-C-Oxidase I (COI).

Results
The molecular delimitation detected 72 to 81 Operational Taxonomic Units (OTU). Only five OTUs could be identified to species level by comparing sequences against the BOLD database using BLAST, and four more to the genus level. Adults and larvae could be successfully associated in 18 cases across six families. The high diversity of Trichoptera in this area highlights their potential as bioindicators for water quality assessment.

Conclusions
This study provides an example of how molecular approaches can benefit the exploration of hidden diversity in unexplored areas and can be a valuable tool to link life stages. However, our study also highlights the need to improve DNA barcode reference libraries of Trichoptera for the Oriental region.
MioceneCupressinoxylonfrom Gökçeada (Imbros), Turkey withProtophytobiacambium mining and the study of ecological signals of wood anatomy
Authors: Mantzouka Dimitra , Akkemik Ünal , Güngör Yıldırım 
Published: December 2022

PremiseThe recognition of the Miocene Climate Optimum (MCO) in terrestrial palaeoenvironments of the Eastern Mediterranean is restricted to Lesbos and Lemnos Islands, Greece. This area is significant for its wood microfossils. A recently-discovered fossil wood assemblage from Gökçeada (Imbros) Island, Turkey, including tree species similar to the Greek findings, is thought to have an early Miocene age. Here, we revise the age of the latter plant fossiliferous locality, re-evaluate the area for the study of MCO for the terrestrial palaeoecosystems of the Eastern Mediterranean and the nomenclature errors referring to the occurrence of fossil wood. We present the plant–insect–environment interactions using detailed anatomical descriptions, of an extinct conifer and its extinct cambium miner feeding traces observed in its secondary xylem.MethodsThree thin sections were prepared with standard palaeoxylotomical techniques from a small section of the silicified wood; the sections were observed under a light microscope. The anatomy of the conifer and its damage patterns were compared with those of extant and fossil Cupressaceae and Agromyzidae, respectively.Pivotal resultsThe common anatomical features of the studied wood specimen andHesperocyparis macrocarpa(Hartw.) Bartel and a shared characteristic (the number of the cross-field pits – a feature we consider of diagnostic value) withXanthocyparis vietnamensisFarjon & T.H. Nguyên led to its assignment to theHesperocyparis–Xanthocyparis–Callitropsisclade. The detailed study of the wound scars and anatomical abnormalities, the anatomical–environmental associations, and structural–functional reactions follow the identification of the wood’s anatomysensuCarlquist providing decisive results.ConclusionsBased on the distinctive characteristics presented, we identify our macrofossil asCupressinoxylon matromnenseGrambast, a stem or an extinct lineage of theHesperocyparis–Xanthocyparis vietnamensis–Callitropsis nootkatensisclade with feeding traces of the fossil cambium miner of the genusProtophytobiaSüss (Diptera: Agromyzidae), and anatomical damage and reaction tissue on adventitious shoots. The use of Protopinaceae andPinoxylonF. H. Knowlton from the eastern Mediterranean are re–evaluated and corrections are provided. The age of the studied plant fossiliferous locality in Gökçeada is revised as middle Miocene, allowing the proposal of an eastern Mediterranean MCO hotspot, including Lesbos, Lemnos, and Gökçeada (Imbros) Islands.
Cu-Chitosan Nanoparticles Stimulated Defence Responses against Bacterial Pustule Disease in Soybean Crop
Authors: Swati . , Joshi Arunabh 
Published: December 2022

Aim: Assessment of Cu-chitosan nanoparticles on controlling Bacterial disease by enhancing the activity of different antioxidant and defence enzymes in soybean.
Study Design: Randomized block Method
Place and Duration of Study: Department of Molecular biology and Biotechnology (MBBT), RCA, Maharana Pratap University of Agriculture and Technology, Udaipur Sub humid southern plain region of India between 2017-2019.
Methodology: We synthesized, characterized and tested the efficacy of Copper-chitosan Nanoparticles against Bacterial Pustule disease in Soybean. Activity of defence related enzymes [polyphenol oxidase (PPO) and phenylalanine ammonia-lyase (PAL)], and antioxidant [peroxidise (POD) and superoxide dismutase (SOD)] were estimated after treating the plants with various concentrations of Cu-chitosan nanoparticles.
Results: Three treatments of Cu-chitosan treatments (0.02, 0.06 and 0.10%) were found most efficient in disease control in both laboratory and net house condition) experiments. Cu-chitosan Nanoparticles application to soybean plants significantly enhanced the activity of defence enzymes (PAL and PPO) and antioxidant enzymes (SOD and POD) from 1.1 to 2.29 folds.
Conclusion: Cu-chitosan NPs developed in this study were effective in controlling disease by enhancing the activity of different defence related enzymes [polyphenol oxidase (PPO) and phenylalanine ammonia-lyase (PAL)], and antioxidant [peroxidise (POD) and superoxide dismutase (SOD)]. This could be an important nonmaterial research in the field of agriculture due to better compatibility of biodegradable Cu-chitosan nanoparticles with biological control. In this study, the effect of Cu-chitosan nanoparticles to boost defence responses against Xanthomonas axonopodis pv. Glycine were evaluated.
Encapsulation of Platinum Prodrugs into PC7A Polymeric Nanoparticles Combined with Immune Checkpoint Inhibitors for Therapeutically Enhanced Multimodal Chemotherapy and Immunotherapy by Activation of the STING Pathway
Authors: Gao Xiangjie , Lei Guanxiong , Wang Bin , Deng Zhong , Karges Johannes , Xiao Haihua , Tan Donghui 
Published: December 2022

AbstractTumor immunotherapy has emerged as one of the most promising therapeutic methods to treat cancer. Despite its clinical application, the immunosuppressive tumor microenvironment compromises the therapeutic efficiency of this technique. To overcome this limitation, many research efforts have been devoted to the development of agents that reprogram the immunosuppressive tumor microenvironment through novel mechanisms. Over the last decade, compounds that intervene through the immunogenic stimulator of interferon genes (STING) pathway have emerged with potential for clinical development. Herein, the encapsulation of chemotherapeutic platinum complexes with a polymer with a cyclic seven‐membered ring (PC7A)‐based polymer into pH‐responsive nanoparticles for multimodal therapeutically enhanced chemotherapy and immunotherapy is presented. This study represents the first nanomaterial with a dual activation mechanism of the STING pathway through DNA fragmentation as well as PC7A binding. The combination of these nanoparticles with immune checkpoint inhibitors demonstrates to nearly fully eradicate a colorectal tumor inside the mouse model by chemotherapy and immunotherapy using the STING pathway.
A new entrant in ketene family: Generation of 2‐(3‐Oxo‐allyl)‐isoindole‐1,3‐dione and their [4+2] Cycloadditions with 1,3‐Diazabuta‐1,3‐dienes
Authors: Naikoo Rayees Ahmad , Sharma Rashmi , Kumar Rupesh , Bhargava Gaurav 
Published: December 2022

AbstractThe manuscript describes a synthetic route for the formation of 5‐(methylisoindole‐1,3‐dione) pyrimidinones by [4+2] cycloaddition reactions of functionalized 1,3‐diazabuta‐1,3‐dienes with 2‐(3‐Oxo‐allyl)‐isoindole‐1,3‐dione generated in situ from phthaloylalanine and tosyl chloride using triethylamine as a base. The functionalized 5‐(methylisoindole‐1,3‐dione) pyrimidinones were further explored in the deprotection of amines to afford a variety of 5‐methylamino pyrimidinones. The synthesis of such functionalized pyrimidinones is significant as they have a wide range of pharmacological profiles and are valuable as organic synthons. Mechanistic insights are also proposed for the given synthetic methodology.
A Melt‐Quenched Luminescent Glass of an Organic–Inorganic Manganese Halide as a Large‐Area Scintillator for Radiation Detection
Authors: Luo Jian‐Bin , Wei Jun‐Hua , Zhang Zhi‐Zhong , He Zi‐Lin , Kuang Dai‐Bin 
Published: December 2022

AbstractGlass is a group of materials with appealing qualities, including simplicity in fabrication, durability, and high transparency, and they play a crucial role in the optics field. In this paper, a new organic–inorganic metal halide luminescent glass exhibiting >78 % transmittance at 506–800 nm range together with a high photoluminescence quantum yield (PLQY) of 28.5 % is reported through a low‐temperature melt‐quenching approach of pre‐synthesized (HTPP)2MnBr4 (HTPP=hexyltriphenylphosphonium) single crystal. Temperature‐dependent X‐ray diffraction, polarizing microscopy, and molecular dynamics simulations were combined to investigate the glass‐crystal interconversion process, revealing the disordered nature of the glassy state. Benefiting from the transparent nature, (HTPP)2MnBr4 glass yields an outstanding spatial resolution of 10 lp mm−1 for X‐ray imaging. The superb optical properties and facility of large‐scale fabrication distinguish the organic–inorganic metal halide glass as a highly promising class of materials for optical devices.
The continuing evolution of a cancer prevention, screening, and survivorship ECHO: A second year of implementation
Authors: Etling Mary Ann , Vik Terry A. , Janota Andrea D. , Liang Kaley L. , Kryder‐Reid Caroline L. , Robertson Mary , Scanlon Caitlin , Carson Anyé , Agley Jon , Severance Tyler S. 
Published: December 2022

AbstractIntroductionAn estimated 39,010 Indiana residents were diagnosed with cancer in 2021. To address the cancer burden, Project ECHO (Extension Community Healthcare Outcomes) was launched in 2019 in Indiana to build specialty healthcare capacity among non‐specialists. Due to positive outcomes from the pilot year, the Cancer Prevention, Screening, and Survivorship ECHO was implemented for a second year. The purpose of this study was to measure the participation and regional impact of this ECHO.MethodsECHO sessions occurred twice monthly from October 2020 to October 2021. Changes were implemented in response to feedback from the pilot year, including making the curriculum more practical for learners and adding accreditation opportunities. Participant information and feedback was extracted from electronic surveys for review.ResultsThere were 24 ECHO sessions with 213 unique participants, increased from 140 unique participants in the pilot year. An average of 23.5 individuals attended each session, increased from 15.5 individuals per session. Enrolled participants served in a diverse set of roles and represented 247 zip codes, 30 Indiana counties, and 32 states across the United States, each of which increased from the pilot year.DiscussionIn this second year, this ECHO expanded to reach more participants with increased attendance and a more diverse distribution of roles within healthcare, which may be attributed to feedback‐driven curriculum design. Cancer care is multi‐disciplinary, with health educators, nurses, and administrators, each acting within the cancer care continuum. As a result, this ECHO has been adapted to serve an increasingly broad distribution of professionals.ConclusionThe second year of the Cancer Prevention, Screening, and Survivorship ECHO displayed increased overall enrollment and participation, greater diversity among participant roles, and a wider reach across Indiana and the United States.
A customized deep learning framework for skin lesion classification using dermoscopic images
Authors: Sahoo Sandhya Rani , Dash Ratnakar , Mohapatra Ramesh Kumar 
Published: December 2022

AbstractAutomated analysis of skin lesions in dermoscopy images has gained much attention due to its medical importance in the early detection of melanoma. Detection of lesions has become a challenge due to the strong visual similarity between benign and malignant skin lesions. In this research, a customized deep convolutional neural network (CNN) architecture has been designed to discriminate between benign and malignant lesions. The model is designed carefully with lesser convolution layers, fewer filters, and parameters to achieve better classification performance compared to pretrained VGG16, ResNet50, InceptionV3 models and, ensures state‐of‐the‐art performance. The proposed model is composed of nine trainable layers: eight convolution layers and one fully connected layer. The suggested framework is extensively evaluated on the benchmark ISIC 2016 challenge dataset. The effect of different input transformations over the dataset has been studied. For fair comparison, standard deep learning models such as VGG16, ResNet50, and InceptionV3 have been used for lesion classification using transfer learning approach. The memory requirement of the proposed model is reduced by 388, 68, and 63 times and FLOPs needed are lowered by 95%, 85%, and 84% compared to VGG16‐TrL, ResNet50‐TrL, and InceptionV3‐TrL, respectively. Results show that class balancing with external images improves classification performance.
Enzyme‐Polymer Conjugates for Tuning, Enhancing, and Expanding Biocatalytic Activity
Authors: Heredero Marcos , Beloqui Ana 
Published: December 2022

AbstractCombining polymers with functional proteins is an approach that has brought several successful stories in the field of biomedicine with PEGylated therapeutic proteins. The latest advances in polymer chemistry have facilitated the expansion of protein‐polymer hybrids to other research areas such as biocatalysis. Polymers can impart stability and novel functionalities to the enzyme of interest, thereby improving the catalytic performance of a given reaction. In this review, we have revisited the main methodologies currently used for the synthesis of enzyme‐polymer hybrids, unveiling the interplay between the configuration and the composition of the assembled structure and the eventual traits of the hybrid. Finally, the latest advances, such as the assembly of polymer‐based chemoenzymatic nanoreactors and the use of deep learning methodologies to achieve the most suitable polymer compositions for catalysis, are discussed.
Infected nasal gout tophus: A case report
Authors: Verstappen Gill , Michel Olaf , Halewyck Stijn , Topsakal Vedat , Pössneck Antje 
Published: December 2022

AbstractGout is a common form of inflammatory arthritis, characterized by the deposition of monosodium urate crystals. If chronically present and not adequately treated by serum urate reducers, gout tophi can develop at various locations. Here, we report the first infected gout tophus at the septal cartilage and nasal tip.
Counselors’ challenging experience in integrated behavioral healthcare: A qualitative exploration
Authors: Li Chi , Zhu Peitao , Loveless Courtney 
Published: December 2022

AbstractUsing a consensual qualitative research method, we interviewed 16 counselors on the challenges that they experienced when working in integrated behavioral healthcare settings. We identified five domains and 13 core ideas among all domains. We also discussed the implications for future counselor training and research.