bluuebunny/crossref_metadata_2025_split huggingface dataset:
Let-7i-3p inhibits the cell cycle, proliferation, invasion, and migration of colorectal cancer cells via downregulating CCND1
Authors: Tu Fei , Li Mengfan , Chen Yinyu , Chu Huiru , Wang Shujie , Hai Lun , Xie Ting , Geng Fangfang , Zhao Tiesuo , Wang Qingzhi , Feng Zhiwei 
Published: June 2022

Abstract
Dysregulated microRNAs are closely related to the malignant progression of colorectal cancer (CRC). Although abnormal let-7i-3p expression has been reported in various human cancers, its biological role and potential mechanism in CRC remain unclear. Therefore, the purpose of this study was to investigate the expression and regulation of let-7i-3p in CRC. Here, we demonstrated that let-7i-3p expression was significantly downregulated in three CRC cell lines while CyclinD1 (CCND1) was upregulated compared with the normal colon epithelial FHC cells. Moreover, bioinformatics and luciferase reporter assays revealed that CCND1 was a direct functional target of let-7i-3p. In addition, let-7i-3p overexpression or CCND1 silencing inhibited cell cycle, proliferation, invasion, and migration and diminished the activation of p-ERK in HCT116 cells. However, exogenously expressing CCND1 alleviated these effects. Taken together, our findings may provide new insight into the pathogenesis of CRC and let-7i-3p/CCND1 might function as new therapeutic targets for CRC.
Effect of heat-treatment on crash performance in bumper beam and crash box design and optimization of the system
Authors: Öztürk İsmail , Kaya Burak Sercan 
Published: June 2022

Abstract
Within the study’s scope, impact analyses of homogeneous bumper beam-crash box systems designed from AA6063-O, AA6063-T5, and AA6063-T6 materials and hybrid systems designed from combinations of these materials were made and compared in terms of energy absorption values. In designs where failure does not occur, the highest energy absorption value was obtained using the AA6063-T5 bumper beam and AA6063-O crash box system, and single and multi-objective optimization studies were conducted using this design. The optimal bumper system improved the crash performance of the structure. Accordingly, this bumper system can be used in vehicles to improve crashworthiness.
Numerical analysis of bent aluminium sandwich panels with different tubular cores
Authors: Eksi Seçil 
Published: June 2022

Abstract
Sandwich panels are frequently used in transportation, automotive, aerospace and marine sectors due to their high rigidity, strength and ability to absorb energy. In this study, finite element analyses investigated the bending behaviour of aluminium sandwich panels fixed at both ends with different geometrical tubular core structures. The sandwich panels consist of 6063-T5 Aluminium core and 7075-T6 Aluminium skin. The core structure used square, circle, triangle, honeycomb, vertical ellipse and horizontal ellipse tube geometries. The square tube-core sandwich panel has the highest specific load-carrying capacity (SLCC) among the different tube-core geometries. In the square tube-core sandwich panel, where the number of tubes varies, the seven-tube-core panel showed the highest SLCC.
High-sensitive and disposable myocardial infarction biomarker immunosensor with optofluidic microtubule lasing
Authors: Niu Panpan , Jiang Junfeng , Liu Kun , Wang Shuang , Wang Tong , Liu Yize , Zhang Xuezhi , Ding Zhenyang , Liu Tiegen 
Published: June 2022

Abstract
The early diagnosis of myocardial infarction can significantly improve the survival rate in emergency treatment, which is mainly implemented by the immunoassay for myocardial infarction biomarkers such as cardiac troponins in blood. In this work, a disposable optofluidic microtubule whispering gallery mode (WGM) immunosensor for label-free cardiac troponin I-C (cTnI-C) complex detection has been proposed and demonstrated with active interrogation enhancement. The disposable microtubule is simply fabricated by a silica capillary with pressurized tapering technology for thin-wall, and the cTnI antibodies are immobilized on the inner wall surface of the microtubule through the self-adherent polydopamine substrate. By configuring the two coupling microfibers, the double-fiber-coupled microtubule cavity can serve as a tunable filter for the mutual-coupled polarimetric fiber ring laser (FRL), whose output laser wavelength is determined by the cTnI-C concentration in the optofluidic microtubule with inherent microfluidic channel. Due to the cyclic-cumulative gain of the FRL, the characteristic resonant peak of optical sensing signal is enhanced in the spectral width compression and the optical signal-to-noise ratio improvement, and therefore the optical immunosensor for cTnI-C can be achieved by tracking the output laser wavelength of the FRL conveniently. The dynamic binding and unbinding process of cTnI-C antigen–antibody is illustrated by monitoring the lasing peak wavelength continuously. Our all-fiber immunosensor demonstrated here has the advantages of fast label-free detection, real-time monitor, high sensitivity and disposable sensing element, which can be an innovative detecting tool in early diagnosis of myocardial infarction.
The Witching Body: Ontology and Physicality of the Witch
Authors: Devereux Katherine R. 
Published: June 2022

AbstractThese considerations illuminate an ontology of the witch by first disclosing how “witch,” as a linguistic gesture, carries a world of meaning, ethics, and a culture of being originating in the body. Witches and witchcraft speak to a communal situatedness of being by acknowledging the power we have over ourselves, others, and that singular lack of control we often experience in everyday life. In dialogue with Ada Agada, Emmanuel Lévinas, and Maurice Merleau-Ponty, I offer an interpretation of the body schema through what I call the “witching-body,” drawing on historical and anthropological examples of witchcraft as related to personhood, thus demonstrating how embodiment philosophy and ontology are already alive in everyday ritual and magical acts. I explain the other’s contradiction of everydayness and transcendence through the reflexivity of self-sensing-self and how aspects of our own body, such as organs and emotions, may be occult or other to us. The everydayness of witchcraft and the ungraspable ambiguity of the witch speak to this necessary transcendence we experience with everyday others; there is both a banality and an infinite plurality. We yearn to know the witch because through the embodied existential expressions of “witch” we find what constitutes being a person.
Of Coase, Cattle, and Crime: Why the Becker Model is Compatible with a Moral Theory of Criminal Law
Authors: Miceli Thomas J. 
Published: June 2022

Abstract
The economic model of crime is often portrayed (and criticized) as being contrary to a moral theory of criminal law. This paper advances the opposing view that the two theories are in fact potentially compatible with one another. The basis for this claim is that, whereas the Becker (1968. Crime and punishment: an economic approach. J. Polit. Econ. 76: 169–217) model is useful in prescribing a theory of optimal enforcement of the law, it does not, and indeed cannot, provide a definitive prescription for its content. The reason is the reciprocal nature of harm in situations involving incompatible rights, a principle first identified by Coase (1960. The problem of social cost. J. Law Econ. 3: 1–44) in the general context of externalities. The paper develops this argument, offers a formal demonstration of it, and draws out some of its implications.
A threshold model for the spread
Authors: Hatzinikolaou Dimitris , Sarigiannidis Georgios 
Published: June 2022

Abstract
Using annual data from two panels, one of 11 Eurozone countries and another of 31 OECD countries, we estimate a two-regime log-linear as well as a nonlinear model for the spread as a function of macroeconomic and quality-of-institutions variables. The two regimes, a high-spread and a low-spread regime, are distinguished by using a threshold, in accordance with the perceived “fair” value of the spread as a reference point. Our results suggest that government-bond spreads are regime-dependent, as most of the regression coefficients of the determinants of the spread are larger (in absolute value) in the high-spread regime than in the low-spread regime. That is, an improvement in the macroeconomic environment (e.g., lower unemployment, lower inflation, lower growth of the debt-to-GDP ratio, less macroeconomic uncertainty, higher growth of real GDP), and/or an improvement in the quality of institutions (e.g., less corruption) reduce the spread facing a country (by enhancing its creditworthiness) to a greater extent in high-spread situations than in low-spread situations. A possible explanation is that the demand for and the supply of loans are inelastic at higher than “fair” interest rates and elastic at lower rates.
Quantitative assessment of a beam hole scatter correction in industrial computed tomography
Authors: Kaufmann Manuel , Pfaffelhuber Carla , Vater Ingo , Wiest Wolfram , Höhe Hendrik , Effenberger Ira 
Published: June 2022

Abstract
In industrial Computed Tomography (CT), scattered radiation causes a loss of quality of the reconstructed 3D volume. Scatter is caused by photon-matter interaction, whereby a photon is deflected from its initial propagation direction. The most prominent contributor to scattered radiation in the scope of photon energies occurring in industrial CT is Compton Scattering. With the used Beam Hole Array (BHA) technology for scatter correction, scatter intensities are determined by subtracting the primary intensities, which are gathered behind small apertures from the total intensities, which are gathered in the absence of the apertures. Intensities measured behind the apertures are assumed to be scatter free, since the transversal components of the radiation are strongly reduced. The scatter correction is performed by subtracting scatter intensities from primary intensities in the projection image. Improvements are evaluated for a newly developed test specimen considering image quality metrics and dimensional accuracy. The contrast could be improved especially for small structures. Cupping artifacts that express as systematic offset of grey values rising with the penetration length were reduced. Measurement deviations towards tactile references were decreased.
Experimentelle Untersuchung des Betriebsverhaltens von Planetenrollengewindetrieben
Authors: Brecher Christian , Axelrad Gabriel , Neus Stephan 
Published: June 2022

Abstract
Für Anwendungen, in denen Linearaktoren mit besonders hohen Tragfähigkeiten und sehr großen Kraftübersetzungen benötigt werden, können neuartige Planetenrollengewindetriebe (PRGT) mit unterschiedlichen Gewindegangzahlen von Spindel und Mutter eingesetzt werden. Das Betriebsverhalten dieser Komponenten weicht von marktverfügbaren Standard-PRGT ab und ist insbesondere im Bereich hoher Axiallasten weitgehend unerforscht. Im vorliegenden Beitrag werden daher Versuche auf einem am Werkzeugmaschinenlabor WZL der RWTH Aachen entwickelten Hochlastprüfstand beschrieben, anhand derer das Betriebsverhalten hinsichtlich Steigung, Wirkungsgrad und Steifigkeit untersucht werden kann.
Intuitives Bedienkonzept für Gabelstapler
Authors: Feiner Leonhard , Geisel Viktoria , Fottner Johannes 
Published: June 2022

Abstract
Bisher werden Gabelstapler durch herstellerspezifische Bedienkonzepte gesteuert. Vor allem für unerfahrene Mitarbeiter sind diese nicht intuitiv nutzbar. Ein neuartiges Bedienkonzept, bei dem die Bewegungsachsen des Bedienelements und der Maschine übereinstimmen, soll dies verbessern. Eine Probandenstudie konnte zeigen, dass dadurch insbesondere bei wenig erfahrenen Benutzern eine Reduzierung der Bedienfehler sowie eine Erhöhung der Gebrauchstauglichkeit und Intuitivität erreicht werden können.
Fabrikplanung 5.0 in und mit Virtual Reality
Authors: Schlegel Marc , Bracht Uwe 
Published: June 2022

Abstract
Menschen sind von Natur aus auf die Orientierung im dreidimensionalen Raum eingerichtet. Sie denken und leben dreidimensional; deshalb ist es ein unersetzbarer Vorteil, bereits die Planung und Gestaltung von Fabriken sowie deren laufende Optimierung dreidimensional durchführen zu können. Im folgenden Beitrag wird eine bahnbrechende, detaillierte Gesamtmethodik vorgestellt, die umfassend den Layoutplanungsprozess über alle Planungsebenen hinweg in die Virtuelle Realität transferiert. Mehrere praktische Anwendungsbeispiele dokumentieren die grundlegende Innovation und zeigen die großen Nutzenpotenziale auf.
Differential Responsiveness for Strength Gain Between Limbs After Resistance Training in Older Women: Impact on Interlimb Asymmetry Reduction
Authors: Nunes João Pedro , Marcori Alexandre J. , Ribeiro Alex S. , Cunha Paolo M. , Kassiano Witalo , Costa Bruna D.V. , Aguiar Andreo F. , Nakamura Masatoshi , Mayhew Jerry L. , Cyrino Edilson S. 
Published: June 2022

Abstract
Nunes, JP, Marcori, AJ, Ribeiro, AS, Cunha, PM, Kassiano, W, Costa, BDV, Aguiar, AF, Nakamura, M, Mayhew, JL, and Cyrino, ES. Differential responsiveness for strength gain between limbs after resistance training in older women: Impact on interlimb asymmetry reduction. J Strength Cond Res 36(11): 3209–3216, 2022—The present study compared strength responses between preferred (PREF) and nonpreferred (N-PREF) legs in older women. Muscular strength was measured unilaterally using an isokinetic dynamometer and was analyzed for reproducibility scores, acute performance, and responsiveness to a resistance training (RT) program. One hundred eleven women (aged ≥60 years) performed 12 weeks of whole-body RT (3 times a week; 4 lower-body exercises). Reproducibility scores (intraclass correlation coefficient ≥0.920; following test-retests in part of the sample at pretraining; n = 19), average acute performances, and average strength gains (PREF = ∼6.9%; N-PREF = ∼7.2%) were similar between legs (p > 0.05). However, the individual analyses showed that some subjects were considered responders to strength gains in 1 leg, whereas nonresponders in the other. Nonetheless, when considering the responses in all strength tests, most subjects (91%) were considered responder to at least 1 measure. In addition, it was observed that the strength ratio between PREF/N-PREF legs was altered for those who presented some asymmetry at baseline, as the limbs became more symmetrical in all strength measures after the RT. In conclusion, we observed that some older women may have different levels of strength between legs; however, a traditional 12-week RT program with bilateral exercises can reduce such asymmetry by inducing greater strength gains in the weaker leg.
No Effect of Interset Palm Cooling on Acute Bench Press Performance, Electromyography Amplitude, or Spectral Frequencies in Resistance-Trained Men
Authors: McMahon Gerard , Kennedy Rodney , Burden Adrian 
Published: June 2022

Abstract
McMahon, G, Kennedy, R, and Burden, A. No effect of interset palm cooling on acute bench press performance, electromyography amplitude or spectral frequencies in resistance-trained men. J Strength Cond Res 37(3): 555–563, 2023—Previous research has suggested that cooling distal to the working agonist muscles during the interset rest periods of high-intensity resistance exercise may facilitate improved performance through increased agonist activation. However, these studies have used inappropriate electromyography (EMG) normalization techniques. Therefore, the aim of this study was to compare 2 palm-cooling conditions with a thermoneutral condition during high-intensity resistance exercise and subsequent effects on exercise performance, EMG amplitude, and spectral frequencies using appropriate normalization methodologies. Eleven healthy, resistance-trained, young men (20–36 years old) performed 4 sets of bench press exercise to exhaustion at 80% 1RM each separated by 3 minutes of passive recovery. Palm-cooling (10° C [TEN] or 15° C [FTN]) or thermoneutral (28° C [CON]) conditions were applied for 60 seconds during the recovery interval of each set in a randomized, double-blind fashion, with 4 days of recovery between experimental conditions. Palm temperature was significantly lower (p < 0.05) in the TEN and FTN conditions compared with CON. Number of repetitions and mean power in the bench press declined significantly after each set in all conditions (p < 0.05). There were no significant differences (p > 0.05) in any bench press performance or EMG-related variables between any of the conditions. Palm cooling at either 10 or 15° C had no effects on bench press performance compared with a thermoneutral condition, with no observable effects on neuromuscular responses during exercise. Therefore, cooling is not currently recommended as an ergogenic strategy to enhance acute bench press performance during high-intensity resistance training.
Validity of Bioelectric Impedance in Relation to Dual-Energy X-Ray Absorptiometry for Measuring Baseline and Change in Body Composition After an Exercise Program in Stroke
Authors: Vanzella Lais M. , Lawand Robert , Shuaib Marya , Oh Paul , Corbett Dale , Marzolini Susan 
Published: June 2022

Abstract
Vanzella, LM, Lawand, R, Shuaib, M, Oh, P, Corbett, D, and Marzolini, S. Validity of bioelectric impedance in relation to dual-energy x-ray absorptiometry for measuring baseline and change in body composition after an exercise program in stroke. J Strength Cond Res 36(12): 3273–3279, 2022—Exercise is an important strategy to improve fat-free mass (FFM) and reduce percent fat mass (FM%). However, no study has reported on a valid, cost-effective method to measure changes in body composition after stroke. The purpose of the study is to determine the level of agreement between bioelectrical impedance analysis (BIA) and dual-energy x-ray absorptiometry (DXA) for assessing baseline and change in FFM and FM% after an exercise training intervention for individuals with mobility deficits after stroke. Fat-free mass and FM% were measured by BIA and DXA at the beginning and after 6 months of participation in an exercise program for individuals with mobility deficits after stroke. Forty-two subjects after stroke were included. Overall, Bland-Altman plots revealed that BIA overestimated the baseline FFM and FM% by only −0.4 ± 1.8 kg and −2.8 ± 1.8%, respectively. BIA underestimated changes in FFM by 0.33 ± 0.45 kg and overestimated changes in FM% by −0.40 ± 0.68%. The 95% CI of the mean bias for baseline FFM was −7.1 to 6.3 kg and −11.8 to 6.0% for FM%, demonstrating good agreement. The 95% CI for the change in FFM was −3.8 to 4.5 kg and −5.0 to 4.2% for FM%, which reflected good agreement. BIA is a good tool for assessing qualitative baseline and change in FFM and FM%. Body composition is important for the prescription and evaluation of rehabilitation programs designed for individuals after stroke. Our results provide clinicians and researchers with a better understanding of the utility of BIA to measure body composition at baseline and in response to exercise interventions in this population.
How Accurate Are Coaches in Predicting Perceived Exertion of Their Athletes?
Authors: Ryan Greg A. , Bunn Jennifer A. , Eisenman Michelle L. 
Published: June 2022

Abstract
Ryan, GA, Bunn, JA, and Eisenman, ML. How accurate are coaches in predicting perceived exertion of their athletes? J Strength Cond Res 37(3): 684–687, 2023—Ratings of perceived exertion (RPE) are used extensively to subjectively evaluate workload in sport. The purpose of this study was to compare season long player to coach perceptions of RPE loads (RPEL) in Division I men's soccer and women's lacrosse programs. Coach and player self-reported RPE were collected during the competitive seasons for both teams within 30 minutes of training sessions. Scores of RPE were multiplied by recorded training time to determine RPEL and averaged to create a daily coach and player RPEL. Accuracy of RPEL prediction between coaches and players was determined via mean bias, mean absolute percent error (MAPE), correlation, and an equivalence test. Soccer coaches underestimated RPEL (1,345 ± 410 arbitrary unit [AU]) compared with players (1,372 ± 435 AU). The coach mean bias was −27.3 ± 151.9 AU, wieth an MAPE of 7.4%, a strong correlation (r = 0.937, p < 0.001), and coach to player equivalence (p = 0.045). Lacrosse coaches overestimated RPELs (876 ± 349 AU) compared with players (829 ± 214 AU). The coach mean bias was 47 ± 189 AU, with an MAPE of 14.7%, a strong correlation (r = 0.883, p < 0.001), and coach to player equivalence (p = 0.010). Analyses indicated that coaches accurately predicted player RPEL within both sports. Variance occurred on days with high RPELs, with overestimations occurring in lacrosse and underestimation in soccer. Coaches can use RPELs to assess subjective training load but should consider objective measures, including microtechnology, to provide a comprehensive assessment.
Collagen Gene Polymorphisms Previously Associated with Resistance to Soft-Tissue Injury Are More Common in Competitive Runners Than Nonathletes
Authors: Dines Hannah R. , Nixon Jennifer , Lockey Sarah J. , Herbert Adam J. , Kipps Courtney , Pedlar Charles R. , Day Stephen H. , Heffernan Shane M. , Antrobus Mark R. , Brazier Jon , Erskine Robert M. , Stebbings Georgina K. , Hall Elliott C.R. , Williams Alun G. 
Published: June 2022

Abstract
Dines, HR, Nixon, J, Lockey, SJ, Herbert, AJ, Kipps, C, Pedlar, CR, Day, SH, Heffernan, SM, Antrobus, MR, Brazier, J, Erskine, RM, Stebbings, GK, Hall, ECR, and Williams, AG. Collagen gene polymorphisms previously associated with resistance to soft-tissue injury are more common in competitive runners than nonathletes. J Strength Cond Res XX(X): 000–000, 2022—Single-nucleotide polymorphisms (SNPs) of collagen genes have been associated with soft-tissue injury and running performance. However, their combined contribution to running performance is unknown. We investigated the association of 2 collagen gene SNPs with athlete status and performance in 1,429 Caucasian subjects, including 597 competitive runners (354 men and 243 women) and 832 nonathletes (490 men and 342 women). Genotyping for COL1A1 rs1800012 (C > A) and COL5A1 rs12722 (C > T) SNPs was performed by a real-time polymerase chain reaction. The numbers of “injury-resistant” alleles from each SNP, based on previous literature (rs1800012 A allele and rs12722 C allele), were combined as an injury-resistance score (RScore, 0–4; higher scores indicate injury resistance). Genotype frequencies, individually and combined as an RScore, were compared between cohorts and investigated for associations with performance using official race times. Runners had 1.34 times greater odds of being rs12722 CC homozygotes than nonathletes (19.7% vs. 15.5%, p = 0.020) with no difference in the rs1800012 genotype distribution (p = 0.659). Fewer runners had an RScore 0 of (18.5% vs. 24.7%) and more had an RScore of 4 (0.6% vs. 0.3%) than nonathletes (p < 0.001). Competitive performance was not associated with the COL1A1 genotype (p = 0.933), COL5A1 genotype (p = 0.613), or RScore (p = 0.477). Although not associated directly with running performance among competitive runners, a higher combined frequency of injury-resistant COL1A1 rs1800012 A and COL5A1 rs12722 C alleles in competitive runners than nonathletes suggests these SNPs may be advantageous through a mechanism that supports, but does not directly enhance, running performance.