bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mendelian Randomization Study on Causal Association of Pyroglutamine with COVID-19
Authors: Su Wenting , Zhou Shan , Zhu Gaizhi , Xu Yaqi , Gao Ran , Zhang Min , Zeng Qi , Wang Renxi 
Published: October 2022

Abstract
Background
Glutamine family amino acids such as glutamate, pyroglutamate, and glutamine have been shown to play important roles in COVID-19. However, it is still unclear about the role of pyroglutamate in COVID-19. Thus, we use a two-sample Mendelian randomization (MR) study to identify the genetic causal link between blood pyroglutamine levels and COVID-19 risk.

Methods
Pyroglutamine genetic instrumental variables (IVs) were chosen from the largest pyroglutamine-associated genome-wide association studies (GWAS). The largest COVID-19 GWAS dataset was employed to evaluate the causal link between blood pyroglutamine levels and COVID-19 risk using two-sample MR analysis.

Results
We found no significant pleiotropy or heterogeneity of pyroglutamine-associated genetic IVs in COVID-19 GWAS. Interestingly, we found that as pyroglutamine genetically increased, the risk of COVID-19 decreased using inverse variance weighted (IVW) (Beta = − 0.644, p = 0.003; OR = 0.525, 95% CI [0.346–0.798]) and weighted median (Beta = − 0.609, p = 0.013; OR = 0.544, 95% CI [0.337–0.878]).

Conclusion
Our analysis suggests a causal link between genetically increased pyroglutamine and reduced risk of COVID-19. Thus, pyroglutamine may be a protective factor for patients with COVID-19.
Shining a Light in a Dark Corner: Does EDGAR Search Activity Reveal the Strategically Leaked Plans of Activist Investors?
Authors: Flugum Ryan , Lee Choonsik , Souther Matthew E. 
Published: October 2022

AbstractWe provide evidence of a network of information flow between activists and other investors prior to 13D filings. We match EDGAR search activity to investor IP addresses, identifying specific investors who persistently download information on an individual activist’s campaign targets in the days prior to that activist’s 13D disclosures. This outside investor’s knowledge of pending activist campaign plans seems to benefit both parties: the informed investor, unnamed in the 13D, increases its holdings in the targeted stock prior to the price surge upon 13D disclosure, while the activist earns voting support that increases their likelihood of pursuing and winning a proxy fight.
Differences in the morphological body condition index of sea turtles between species and size classes
Authors: Nishizawa Hideaki , Joseph Juanita 
Published: October 2022

AbstractThe body condition of animals is an important indicator of their habitats and the effects of anthropogenic activities and pollution. Body condition indices calculated from morphometric measurements have been widely employed as they are easy to use and inexpensive. In sea turtles, Fulton's condition index, calculated as the bodyweight divided by the cube of straight carapace length (SCL), has been commonly used and it has been proposed that an index of ≥1.2 indicates a good body condition. However, comparing Fulton's condition index between different species and size classes is problematic as it does not consider the mass-length relationship. In this study, we conducted a meta-analysis to evaluate the differences between sea turtles. A literature review indicated that most studies reported the SCL-based Fulton's condition index for green turtles (Chelonia mydas), followed by loggerhead turtles (Caretta caretta) and hawksbill turtles (Eretmochelys imbricata). Therefore, we compared the values reported for healthy turtles of these three species. Meta-analysis supported the adequacy of 1.2 as a threshold in juvenile and adult green turtles and large juvenile and adult loggerhead turtles. High Fulton's condition index values were found for hatchlings and post-hatchlings of all three species and small loggerhead turtle juveniles. Low Fulton's condition index values were found for hawksbill turtles, particularly small juveniles. The differences in the Fulton's condition index between species and size classes indicated that it should be used carefully as a threshold for health condition evaluation.
Clinical and psychological factors associated with resilience in patients with schizophrenia: data from the Italian network for research on psychoses using machine learning
Authors: Antonucci Linda A. , Pergola Giulio , Rampino Antonio , Rocca Paola , Rossi Alessandro , Amore Mario , Aguglia Eugenio , Bellomo Antonello , Bianchini Valeria , Brasso Claudio , Bucci Paola , Carpiniello Bernardo , Dell'Osso Liliana , di Fabio Fabio , di Giannantonio Massimo , Fagiolini Andrea , Giordano Giulia Maria , Marcatilli Matteo , Marchesi Carlo , Meneguzzo Paolo , Monteleone Palmiero , Pompili Maurizio , Rossi Rodolfo , Siracusano Alberto , Vita Antonio , Zeppegno Patrizia , Galderisi Silvana , Bertolino Alessandro , Maj Mario ,   Italian Network for Research on Psychoses
Published: October 2022

AbstractBackgroundResilience is defined as the ability to modify thoughts to cope with stressful events. Patients with schizophrenia (SCZ) having higher resilience (HR) levels show less severe symptoms and better real-life functioning. However, the clinical factors contributing to determine resilience levels in patients remain unclear. Thus, based on psychological, historical, clinical and environmental variables, we built a supervised machine learning algorithm to classify patients with HR or lower resilience (LR).MethodsSCZ from the Italian Network for Research on Psychoses (N= 598 in the Discovery sample,N= 298 in the Validation sample) underwent historical, clinical, psychological, environmental and resilience assessments. A Support Vector Machine algorithm (based on 85 variables extracted from the above-mentioned assessments) was built in the Discovery sample, and replicated in the Validation sample, to classify between HR and LR patients, within a nested, Leave-Site-Out Cross-Validation framework. We then investigated whether algorithm decision scores were associated with the cognitive and clinical characteristics of patients.ResultsThe algorithm classified patients as HR or LR with a Balanced Accuracy of 74.5% (p< 0.0001) in the Discovery sample, and 80.2% in the Validation sample. Higher self-esteem, larger social network and use of adaptive coping strategies were the variables most frequently chosen by the algorithm to generate decisions. Correlations between algorithm decision scores, socio-cognitive abilities, and symptom severity were significant (pFDR< 0.05).ConclusionsWe identified an accurate, meaningful and generalizable clinical-psychological signature associated with resilience in SCZ. This study delivers relevant information regarding psychological and clinical factors that non-pharmacological interventions could target in schizophrenia.
Repugnant innovation
Authors: Allen Darcy W. E. , Berg Chris , Davidson Sinclair 
Published: October 2022

AbstractRepugnant innovation is a form of evasive entrepreneurship that occurs in repugnant markets. Repugnance is an informal institution – controlled by long-lived norms, attitudes, customs and traditions – and repugnant innovation acts to shift institutions at the lowest level of the institutional stack. The paper considers three examples of repugnant innovation: e-cigarettes, online gambling, and webcam modelling. Each repugnant innovation challenges the complex mixture of material and moral concerns that contributes to repugnance in their respective markets. The paper adds to and expands on a body of evidence about innovation in apparently unsupportive institutional environments.
A circularly polarized wideband implantable patch antenna for biomedical applications
Authors: Pal Aditya , Mishra Piyush Kumar , Tripathi Vijay Shanker 
Published: October 2022

AbstractThis work represents a circularly polarized implantable patch antenna operating at the ISM band (2.4–2.48 GHz) for biomedical applications. The presented patch antenna has a compact volume of 50 mm3i.e., 10 × 10 × 0.5 mm3. All the Simulations have been carried out within homogeneous skin phantom and head scalp phantom. Miniaturization of antenna and enhancement of bandwidth is achieved by using various techniques described in this work. The designed patch antenna has wide axial ratio bandwidth of 20.08 and 15.44% inside scalp phantom and homogeneous skin phantom, respectively. Obtained impedance bandwidths are 56.79 and 49.75% inside scalp phantom and homogeneous skin phantom, respectively. At 2.45 GHz, obtained peak gains are −25.18 and −28.12 dB, respectively. The proposed antenna is enclosed in a biocompatible material to avoid direct contact with the human tissue. For patient safety concerns, simulated maximum specific absorption ratio values are also investigated and are under the limits of the IEEE standard. The allowable input power is also calculated in this work. Link budget analysis is used in this work to determine the far-field communication range of the designed antenna.
Development of CMIP6‐Based Climate Scenarios for Japan Using Statistical Method and Their Applicability to Heat‐Related Impact Studies
Authors: Ishizaki Noriko N. , Shiogama Hideo , Hanasaki Naota , Takahashi Kiyoshi 
Published: October 2022

AbstractClimate scenario data set are indispensable for assessing future climate impacts. In this study, we developed statistically downscaled climate scenarios in Japan using modified bias correction method based on five general circulation models selected from the Coupled Model Intercomparison Project (CMIP) Phase 6 to facilitate impact assessments and adaptation strategies. Modification of time window of the original correction method results in successful agreement with the observed seasonal change of variables in each grid. The original CMIP6 models have a relatively small bias compared to CMIP5 models. The advantage of CMIP6‐based bias‐corrected scenarios is its availability for multiple global circulation models, which covered wide uncertainty in CMIP6 ensembles, with various emissions scenarios for representative concentration pathway (RCP) including RCP4.5, RCP2.6, and RCP8.5. Several temperature‐related indices derived from the CMIP6‐based climate scenarios agreed well with observations. The number of extremely hot days and nights increased nonlinearly in the future with additional global warming. An increase in the global warming level from 1 to 2°C above the early 1900s would increase the probability of the number of extremely hot days per year exceeding the 2018 case by 4.1 times. The development of bias‐corrected climate scenarios facilitates the study of various climate impacts on a CMIP6 basis.
Aufeis as a Major Forcing Mechanism for Channel Avulsion and Implications of Warming Climate
Authors: Wohl Ellen , Scamardo Julianne E. 
Published: October 2022

AbstractPrompted by field observation of an aufeis‐induced channel avulsion along the Hula Hula River in June 2021, we use measurements of channel migration zone width along 15 rivers flowing north across the Arctic coastal plain in Alaska, USA. We differentiated sites with aufeis that covered ≥1 km2 in early summer during the period 2017–2021 from sites without such aufeis formation. All but four of the 28 sites with aufeis have widths greater than the 95% confidence interval and 20 sites fall outside of the 95% prediction interval for channel width based on drainage area. Pairwise comparison indicates that the population of aufeis sites have significantly wider channel migration zones (p < 0.0001) than non‐aufeis sites after accounting for drainage area. Seasonal aufeis facilitates lateral channel migration and associated heterogeneity. Loss of aufeis under warming climate may reduce habitat diversity in these river corridors.
Deformation Mechanisms of Blueschist Facies Continental Metasediments May Offer Insights Into Deep Episodic Tremor and Slow Slip Events
Authors: Giuntoli Francesco , Viola Giulio , Sørensen Bjørn Eske 
Published: October 2022

AbstractExhumed fossil subduction zones are archives of the deformation conditions and mechanisms from depths not directly accessible. Microstructural analysis of samples exhumed therefrom offers insights into the micromechanics and deformation processes associated with subduction such as earthquakes, slow earthquakes, and aseismic creep. Subducted and exhumed continental metasediments of the Tuscan Metamorphic Units of the Italian Northern Apennines contain a mylonitic foliation and quartz and carpholite dilational hydroshear veins with crack‐and‐seal textures, both developed at blueschist facies conditions (350–400°C, ∼1 GPa). As shown by overprinting relationships and mineral assemblages, these two structure types formed broadly coeval within the stability field of carpholite. Metaconglomerates and metaquartzarenites deformed mainly by dissolution‐precipitation creep and secondary by dislocation creep. Microstructural and electron backscatter diffraction analyses of the veins suggest only limited recrystallization of quartz fibers by subgrain rotation recrystallization, with adjacent metapelite bands acting as decollement horizons, likely by slip on the basal plane of phyllosilicates. We estimated differential stresses of 43–55 MPa and strain rates between 10−13 and 10−14 s−1 from the vein recrystallized quartz fibers. We propose these microstructures and deformation mechanisms to represent a geological evidence of deep episodic tremor and slow slip events in subducted continental metasediments. Pore pressure cyclically reached supralithostatic values triggering tremors causing fracturing of all involved lithotypes. Likely, slow slip was accommodated preferentially by slip on phyllosilicate bands. Aseismic creep occurred mainly by dislocation creep with subgrain rotation recrystallization in vein quartz, slip on the basal plane of phyllosilicates, and dissolution and precipitation creep in the host rock.
Dynamic Downscaling Simulation and Projection of Precipitation Extremes Over China Under a Shared Socioeconomic Pathway Scenario
Authors: Luo Neng , Guo Yan , Feng Jin , Ding Ruiqiang , Gao Zhibo , Zhao Zihui 
Published: October 2022

AbstractIn this study, Weather Research and Forecasting (WRF) ‐based dynamic downscaling simulation was performed over China at a horizontal resolution of 25 km. To reduce the systematic large‐scale biases from lateral boundary conditions, a dynamic blending (DB) technique was introduced in downscaling, and its performance was compared with downscaling without DB (NO_DB) as well as the driving global climate model (GCM, i.e., HadGEM3). In the present‐day simulation for verification, added values were found in DB, relative to the GCM and NO_DB, in simulating the precipitation extremes, especially over southeastern China. Possible causes responsible for this improvement were further analyzed. In the GCM, excessive moisture and atmospheric heating in the upper troposphere in conjunction with abnormally strong deep convection resulted in excessive extreme precipitation over southeastern China, while in NO_DB, insufficient moisture and atmospheric heating in the whole troposphere in conjunction with abnormally weak convection suppressed extreme precipitation there. In comparison, DB showed a closer representation of observations in terms of vertical velocity and vertical profiles of atmospheric moisture and heating, accounting for the improved simulation of extreme precipitation. In the future projection under the SSP5‐8.5 scenario, both the GCM and DB predicted that extreme precipitation would increase in most parts of China; however, DB indicated a larger increase over southeastern China relative to the GCM. Stronger moisture flux convergence over southeastern China in DB accounted for this larger increase, and in addition, the thermodynamic effect associated with more precipitable water dominated the stronger moisture flux convergence.
Identification and Geomorphometric Characterization of Volcanic Cones in the Marius Hills, the Moon
Authors: Wan Sheng , Qiao Le , Ling Zongcheng 
Published: October 2022

AbstractInvestigation of the detailed geological characteristics of lunar volcanic cones can peer into their formation and emplacement processes, thus deepening our understanding of pyroclastic eruptions on the Moon. In this work, we focus on the Marius Hills region (centered at 13°N, 55°W), a volcanic plateau in south Oceanus Procellarum, which hosts the most abundant volcanic cones on the Moon, along with other volcanic features. The range of volcanic features indicates various eruption styles and complicated sequences of regional magmatic activities. Based on the SLDEM2015 topography data, with assistance from other multisource topography and image data sets, we identified 360 known and suspected volcanic cones and 22 volcanic domes in the Marius Hills. Following detailed morphological characterizations, the volcanic cones show various morphology types, including C‐shaped, elliptical‐shaped, elongated‐shaped, irregular‐shaped, and rounded‐shaped. The cones (median basal width ∼2.7 km, height ∼115 m, and volume 0.25 km3) contain summit pit craters (15%; median width ∼358 m), exhibiting smaller basal widths and summit pit crater widths compared with lunar mare domes. The mean slope (3.5°–15.6°) and rock abundance (0.3%–3.8%) of volcanic cones in Marius Hills are larger than those of the mare dome, suggesting different eruption mechanisms. Marius Hills cones also show larger basal widths and smaller height/width ratios than terrestrial volcanic cones, which are attributed to multiple factors, including subaerial environment, volatile content of the magma, eruption rate, and lava viscosity.
Versatile platform of nonlocal metasurfaces for both spectral and spatial control of light waves
Authors: Chen Run , Wang Shuming 
Published: October 2022

AbstractMultifunctional nonlocal metasurfaces based on quasi-bound states in the continuum are experimentally demonstrated, which shapes the wavefronts at the resonant wavelengths while have no effect on other wavelengths. By means of cascade and orthogonal perturbations, the nonlocal metasurface devices can be extended to a versatile platform with multifunction.
Barriers to genetic testing in clinical psychiatry and ways to overcome them: from clinicians’ attitudes to sociocultural differences between patients across the globe
Authors: Pinzón-Espinosa Justo , van der Horst Marte , Zinkstok Janneke , Austin Jehannine , Aalfs Cora , Batalla Albert , Sullivan Patrick , Vorstman Jacob , Luykx Jurjen J. 
Published: October 2022

AbstractGenetic testing has evolved rapidly over recent years and new developments have the potential to provide insights that could improve the ability to diagnose, treat, and prevent diseases. Information obtained through genetic testing has proven useful in other specialties, such as cardiology and oncology. Nonetheless, a range of barriers impedes techniques, such as whole-exome or whole-genome sequencing, pharmacogenomics, and polygenic risk scoring, from being implemented in psychiatric practice. These barriers may be procedural (e.g., limitations in extrapolating results to the individual level), economic (e.g., perceived relatively elevated costs precluding insurance coverage), or related to clinicians’ knowledge, attitudes, and practices (e.g., perceived unfavorable cost-effectiveness, insufficient understanding of probability statistics, and concerns regarding genetic counseling). Additionally, several ethical concerns may arise (e.g., increased stigma and discrimination through exclusion from health insurance). Here, we provide an overview of potential barriers for the implementation of genetic testing in psychiatry, as well as an in-depth discussion of strategies to address these challenges.
Cue-induced cocaine craving enhances psychosocial stress and vice versa in chronic cocaine users
Authors: Kexel Ann-Kathrin , Kluwe-Schiavon Bruno , Baumgartner Markus R. , Engeli Etna J. E. , Visentini Monika , Kirschbaum Clemens , Seifritz Erich , Ditzen Beate , Soravia Leila M. , Quednow Boris B. 
Published: October 2022

AbstractStress and craving, it has been found, contribute to the development and maintenance of and relapse in cocaine use disorder. Chronic cocaine users (CU), previous research has shown, display altered physiological responses to psychosocial stress and increased vegetative responding to substance-related cues. However, how psychosocial stress and cue-induced craving interact in relation to the CU’s physiological responses remains largely unknown. We thus investigated the interaction between acute psychosocial stress and cocaine-cue-related reactivity in 47 CU and 38 controls. In a crossed and balanced design, the participants were randomly exposed to a video-based cocaine-cue paradigm and the Trier Social Stress Test (TSST) or vice versa to investigate possible mutually augmenting effects of both stressors on physiological stress responses. Over the course of the experimental procedure, plasma cortisol, ACTH, noradrenaline, subjective stress, and craving were assessed repeatedly. To estimate the responses during the cocaine-cue paradigm and TSST, growth models and discontinuous growth models were used. Overall, though both groups did not differ in their endocrinological responses to the TSST, CU displayed lower ACTH levels at baseline. The TSST did not elevate craving in CU, but when the cocaine-cue video was shown first, CU displayed an enhanced cortisol response to the subsequent TSST. In CU, cocaine-cues robustly evoked craving but no physiological stress response, while cue-induced craving was intensified after the TSST. Taken together, though CU did not show an altered acute stress response during the TSST, stress and craving together seemed to have mutually augmenting effects on their stress response.
Working memory updating in individuals with bipolar and unipolar depression: fMRI study
Authors: Manelis Anna , Halchenko Yaroslav O. , Bonar Lisa , Stiffler Richelle S. , Satz Skye , Miceli Rachel , Ladouceur Cecile D. , Bebko Genna , Iyengar Satish , Swartz Holly A. , Phillips Mary L. 
Published: October 2022

AbstractUnderstanding neurobiological characteristics of cognitive dysfunction in distinct psychiatric disorders remains challenging. In this secondary data analysis, we examined neurobiological differences in brain response during working memory updating among individuals with bipolar disorder (BD), those with unipolar depression (UD), and healthy controls (HC). Individuals between 18–45 years of age with BD (n = 100), UD (n = 109), and HC (n = 172) were scanned using fMRI while performing 0-back (easy) and 2-back (difficult) tasks with letters as the stimuli and happy, fearful, or neutral faces as distractors. The 2(n-back) × 3(groups) × 3(distractors) ANCOVA examined reaction time (RT), accuracy, and brain activation during the task. HC showed more accurate and faster responses than individuals with BD and UD. Difficulty-related activation in the prefrontal, posterior parietal, paracingulate cortices, striatal, lateral occipital, precuneus, and thalamic regions differed among groups. Individuals with BD showed significantly lower difficulty-related activation differences in the left lateral occipital and the right paracingulate cortices than those with UD. In individuals with BD, greater difficulty-related worsening in accuracy was associated with smaller activity changes in the right precuneus, while greater difficulty-related slowing in RT was associated with smaller activity changes in the prefrontal, frontal opercular, paracingulate, posterior parietal, and lateral occipital cortices. Measures of current depression and mania did not correlate with the difficulty-related brain activation differences in either group. Our findings suggest that the alterations in the working memory circuitry may be a trait characteristic of reduced working memory capacity in mood disorders. Aberrant patterns of activation in the left lateral occipital and paracingulate cortices may be specific to BD.