bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rationale and design of the SARCoidosis Outcomes in all respiratory Viral Infectious Diseases (SARCOVID) Study
Authors: Strykowski Rachel , Patel Divya C , Neto Manny Ribeiro , Hena Kerry M , Gulati Mridu , Maier LIsa A , Patterson Karen 
Published: July 2022

IntroductionRespiratory infections are ubiquitous. The COVID-19 pandemic has refocused our attention on how morbid and potentially fatal they can be, and how host factors have an impact on the clinical course and outcomes. Due to a range of vulnerabilities, patients with sarcoidosis may be at higher risk of poor outcomes from respiratory infections. The objective of the SARCoidosis Outcomes in all respiratory Viral Infectious Diseases (SARCOVID) Study is to determine the short-term and long-term impacts of respiratory viral illnesses (COVID-19 and non-COVID-19) in sarcoidosis.Methods and analysisUp to 20 clinical sites across the USA are participating in the recruitment of 2000 patients for this observational, prospective study. To ensure that the study cohort is representative of the general population with sarcoidosis, participating sites include those dedicated to reaching under-represented minorities or patients from non-urban areas. Baseline data on demographic features, comorbidities, sarcoidosis characteristics and pre-enrolment lung function will be captured at study entry. During this 3-year study, all acute respiratory infectious events (from SARS-CoV-2 and any other respiratory pathogen) will be assessed and recorded at quarterly intervals. The level of required medical care and survival outcomes determine infection severity, and the impact of infection on quality of life measures will be recorded. Post-infection lung function and imaging results will measure the long-term impact on the trajectory of sarcoidosis. Patients will be analysed according to the clinical phenotypes of cardiac and fibrotic pulmonary sarcoidosis. Control groups include non-infected patients with sarcoidosis and patients with non-sarcoidosis interstitial lung disease.Ethics and disseminationEach site received local institutional review board approval prior to enrolling patients, with the consent process determined by local institution standards. Data will be published in a timely manner (goal <12 months) at the conclusion of the 3-year follow-up period and will be made available upon request.
CCL17 exerts neuroprotection through activation of CCR4/mTORC2 axis in microglia after subarachnoid haemorrhage in rats
Authors: Zhang Anke , Liu Yibo , Xu Houshi , Zhang Zeyu , Wang Xiaoyu , Yuan Ling , Lenahan Cameron , Zhang Chuan , Jiang Junkun , Fang Chaoyou , Fang Yuanjian , Zhang Jianmin , Chen Sheng 
Published: July 2022

Background and purposeC-C motif chemokine ligand 17 (CCL17) presents an important role in immune regulation, which is critical in the pathophysiology of brain injury after subarachnoid haemorrhage (SAH). There is rare evidence to illustrate the function of CCL17 towards SAH. In this study, we try to reveal the therapeutic effects of CCL17 and its underlying mechanism in rat SAH model.MethodsSAH rat models were assigned to receive recombinant CCL17 (rCCL17) or phosphate buffer saline (PBS). AZD2098 and JR-AB2-011 were applied to investigate the C-C motif chemokine receptor 4 (CCR4)/mammalian target of rapamycin complex 2 (mTORC2) axis in CCL17-mediated neuroprotection. To elucidate the underlying mechanism, the in vitro kinase assay was performed in primary microglia. Microglial-specific Rictor knockdown was administered via intracerebroventricular injection of adenovirus-associated virus. Brain water content, short-term neurobehavioural evaluation, western blot analysis, quantitative RT-PCR and histological staining were performed.ResultsThe expression of CCL17 was increased and secreted from neurons after oxyhaemoglobin stimulation. Exogenous rCCL17 significantly alleviated neuronal apoptosis, and alleviated short-term neurofunction after SAH in rats. In addition, rCCL17 increased M2-like polarisation of microglia in rats post-SAH and in primary microglia culture. The neuroprotection of rCCL17 was abolished via inhibition of either CCR4 or mTORC2.ConclusionCCL17 activated the CCR4/mTORC2 axis in microglia, which can alleviate SAH-induced neurological deficits by promoting M2-like polarisation of microglia.
Jet flavour tagging for future colliders with fast simulation
Authors: Bedeschi Franco , Gouskos Loukas , Selvaggi Michele 
Published: July 2022

AbstractJet flavour identification algorithms are of paramount importance to maximise the physics potential of future collider experiments. This work describes a novel set of tools allowing for a realistic simulation and reconstruction of particle level observables that are necessary ingredients to jet flavour identification. An algorithm for reconstructing the track parameters and covariance matrix of charged particles for an arbitrary tracking sub-detector geometries has been developed. Additional modules allowing for particle identification using time-of-flight and ionizing energy loss information have been implemented. A jet flavour identification algorithm based on a graph neural network architecture and exploiting all available particle level information has been developed. The impact of different detector design assumptions on the flavour tagging performance is assessed using the FCC-ee IDEA detector prototype.
Braneworld cosmological effect on freeze-in dark matter density and lifetime frontier
Authors: Baules Victor , Okada Nobuchika , Okada Satomi 
Published: July 2022

AbstractIn the 5-dimensional braneworld cosmology, the Friedmann equation of our 4-dimensional universe on a brane is modified at high temperatures while the standard Big Bang cosmology is reproduced at low temperatures. Based on two well-known scenarios, the Randall–Sundrum and Gauss–Bonnet braneworld cosmologies, we investigate the braneworld cosmological effect on the relic density of a non-thermal dark matter particle whose interactions with the Standard Model particles are so weak that its relic density is determined by the freeze-in mechanism. For dark matter production processes in the early universe, we assume a simple scenario with a light vector-boson mediator for the dark matter particle to communicate with the Standard Model particles. We find that the braneworld cosmological effect can dramatically alters the resultant dark matter relic density from the one in the standard Big Bang cosmology. As an application, we consider a right-handed neutrino dark matter in the minimal $$B-L$$

B
-
L

extended Standard Model with a light $$B-L$$

B
-
L

gauge boson ($$Z^\prime $$

Z
′

) as a mediator. We find an impact of the braneworld cosmological effect on the search for the long-lived $$Z^\prime $$

Z
′

boson at the planned/proposed Lifetime Frontier experiments.
VALUATION OF GENERAL CONTINGENT CLAIMS WITH SHORT SELLING BANS: AN EQUAL-RISK PRICING APPROACH
Authors: MA GUIYUAN , ZHU SONG-PING , GUO IVAN 
Published: July 2022

This paper studies the valuation of general contingent claims with short selling bans under the equal-risk pricing (ERP) framework proposed in I. Guo & S.-P. Zhu (2017) [Journal of Economic Dynamics and Control 76, 136–151]. In existing literature, analytical pricing formulae were derived in the special case, where the payoff function is monotonic under risk-neutral measures. In this paper, we establish a unified framework for this new pricing approach so that its range of application can be significantly expanded. The results of I. Guo & S.-P. Zhu (2017) [Journal of Economic Dynamics and Control 76, 136–151] are extended to the case of non-monotonic payoffs (such as a butterfly spread option) under risk-neutral measures. We also provide numerical schemes for computing equal-risk prices under other measures such as the original physical measure. Furthermore, we demonstrate how short selling bans can affect the valuation of contingent claims by comparing equal-risk prices with Black–Scholes prices.
The Euler totient function on Lucas sequences
Authors: Saunders J. C. 
Published: July 2022

In 2009, Luca and Nicolae [[Formula: see text], Integers 9 (2009) A30] proved that the only Fibonacci numbers whose Euler totient function is another Fibonacci number are [Formula: see text], and [Formula: see text]. In 2015, Faye and Luca [Pell numbers whose Euler function is a Pell number, Publ. Inst. Math. 101(115) (2017) 231–245] proved that the only Pell numbers whose Euler totient function is another Pell number are [Formula: see text] and [Formula: see text]. Here, we add to these two results and prove that for any fixed natural number [Formula: see text], if we define the sequence [Formula: see text] as [Formula: see text], [Formula: see text], and [Formula: see text] for all [Formula: see text], then the only solution to the Diophantine equation [Formula: see text] is [Formula: see text].
An asymptotic expansion for a Lambert series associated to the symmetric square L-function
Authors: Juyal Abhishek , Maji Bibekananda , Sathyanarayana Sumukha 
Published: July 2022

Hafner and Stopple proved a conjecture of Zagier that the inverse Mellin transform of the symmetric square [Formula: see text]-function associated to the Ramanujan tau function has an asymptotic expansion in terms of the nontrivial zeros of the Riemann zeta function [Formula: see text]. Later, Chakraborty et al. extended this phenomenon for any Hecke eigenform over the full modular group. In this paper, we study an asymptotic expansion of the Lambert series [Formula: see text] where [Formula: see text] is the [Formula: see text]th Fourier coefficient of a Hecke eigenform [Formula: see text] of weight [Formula: see text] over the full modular group.
Modified block-matching algorithm for moving object tracking in video surveillance
Authors: Vasekar Shridevi Sukhadeo , Shah Sanjeevani K. 
Published: July 2022

Video surveillance has risen as one of the most promising methods for people who live alone in their dwellings. Few video surveillance innovations have recently been introduced. However, due to various changes in illumination, abrupt shifts in target appearance, identical non-target artifacts in the background, and occlusions, developing a reliable video surveillance algorithm remains a difficult challenge. This work attempts to introduce a new framework for moving object detection and tracking by following four major phases: “Video-to-Frame Conversion, Pre-Processing, Background Subtraction, Feature-Based Multi-object Detection, Multi-object Tracking by Filtering”. Initially, in the Video-to-Frame Conversion process, the recorded input video clips are transformed into distinct frames. During pre-processing, the noise is removed from the video frame using a filtering approach, and thereby the nature of the images will be enhanced. In the proposed work, a Weiner filter is used to remove noise and other undesirable features during the pre-processing. Then, to distinguish the frontal areas of objects, background subtraction is performed using the neutrosophic set in noiseless video frames (pre-processed frames). The objects in the background-subtracted frames are separated using Improved Region Growing (IRG) segmentation model in the Feature-Based Multi-object Detection phase. The objects in the frames are determined from this segmented image. The Modified Full Search Algorithm is being used to track the object (motion estimation) on the video frame after it has been identified in the segmented phase. The Modified full search block matching algorithm (MFSA) is introduced in this research work to find the appropriate mobility. Promising results have been obtained by the proposed work, and also the mathematical excellence of the new method is also proven over other state-of-the-art models.
Planar Graph Isomorphism Is in Log-Space
Authors: Datta Samir , Limaye Nutan , Nimbhorkar Prajakta , Thierauf Thomas , Wagner Fabian 
Published: July 2022

Graph Isomorphism is the prime example of a computational problem with a wide difference between the best-known lower and upper bounds on its complexity. The gap between the known upper and lower bounds continues to be very significant for many subclasses of graphs as well.We bridge the gap for a natural and important class of graphs, namely, planar graphs, by presenting a log-space upper bound that matches the known log-space hardness. In fact, we show a stronger result that planar graphcanonizationis in log-space.
Deep Ensemble Learning for Human Activity Recognition Using Wearable Sensors via Filter Activation
Authors: Huang Wenbo , Zhang Lei , Wang Shuoyuan , Wu Hao , Song Aiguo 
Published: July 2022

During the past decade, human activity recognition (
HAR
) using wearable sensors has become a new research hot spot due to its extensive use in various application domains such as healthcare, fitness, smart homes, and eldercare. Deep neural networks, especially convolutional neural networks (
CNNs
), have gained a lot of attention in
HAR
scenario. Despite exceptional performance,
CNNs
with heavy overhead is not the best option for
HAR
task due to the limitation of computing resource on embedded devices. As far as we know, there are many invalid filters in
CNN
that contribute very little to output. Simply pruning these invalid filters could effectively accelerate
CNNs
, but it inevitably hurts performance. In this article, we first propose a novel
CNN
for
HAR
that uses filter activation. In comparison with filter pruning that is motivated for efficient consideration, filter activation aims to activate these invalid filters from an accuracy boosting perspective. We perform extensive experiments on several public
HAR
datasets, namely, UCI-HAR (
UCI
), OPPORTUNITY (
OPPO
), UniMiB-SHAR (
Uni
), PAMAP2 (
PAM2
), WISDM (
WIS
), and USC-HAD (
USC
), which show the superiority of the proposed method against existing state-of-the-art (
SOTA
) approaches. Ablation studies are conducted to analyze its internal mechanism. Finally, the inference speed and power consumption are evaluated on an embedded
Raspberry Pi Model 3 B plus
platform.
Assessing the Effects of Climate Change on Middle Rio Grande Surface Water Supplies Using a Simple Water Balance Reservoir Model
Authors: Holmes Robyn N. , Mayer Alex , Gutzler David S. , Chavira Luis Garnica 
Published: July 2022

Abstract
The middle Rio Grande is a vital source of water for irrigation in the region. Climate change is impacting regional hydrology and is likely to put additional stress on a water supply that is already stretched thin. To gain insight on the hydrologic effects of climate change on reservoir storage, a simple water balance model was used to simulate the Elephant Butte–Caballo Reservoir system (southern New Mexico). The water balance model was forced by hydrologic inputs generated by 97 climate simulations derived from CMIP5 global climate models, coupled to a surface hydrologic model. Results suggest that the percentage of years that reservoir releases satisfy agricultural water rights allocations over the next 50 years (2021–70) will decrease relative to the past 50 years (1971–2020). The modeling also projects an increase in multiyear drought events that hinder reservoir management strategies to maintain high storage levels. In most cases, changes in reservoir inflows from distant upstream snowmelt is projected to have a greater influence on reservoir storage and water availability downstream of the reservoirs than will changes in local evaporation and precipitation from the reservoir surfaces.
Cohort Comparison of Radiographic Correction and Complications Between Minimal Invasive and Open Lapidus Procedures for Hallux Valgus
Authors: Vieira Cardoso Diogo , Veljkovic Andrea , Wing Kevin , Penner Murray , Gagne Oliver , Younger Alastair 
Published: July 2022

Background: The Lapidus procedure corrects hallux valgus first ray deformity. First tarsometatarsal (TMT) fusion in patients with hallux valgus deformity using minimally invasive surgery (MIS) is a new technique, but comparative outcomes between MIS and open techniques have not been reported. This study compares the early radiographic results and complications of the MIS with the open procedure in a single-surgeon practice. Methods: 47 MIS patients were compared with 44 open patients. Radiographic measures compared preoperatively and postoperatively were the intermetatarsal angle (IMA), hallux valgus angle (HVA), foot width (FW), distal metatarsal articular angle (DMAA), sesamoid station (SS), metatarsus adductus angle (MAA), first metatarsal to second metatarsal length, and elevation of the first metatarsal. Early complications were recorded, as well as repeat surgeries. Results: The mean follow-up was 82 (range, 31-182) months for the open group and 29 (range, 14-47) months for the MIS group. In both techniques, postoperative measures (IMA, HVA, DMAA, FW, and sesamoid station) were significantly improved from preoperative measures. When comparing postoperative measures between both groups, the IMA was significantly lower in the open group (4.8 ± 3.6 degrees vs 6.4 ± 3.2 degrees, P < .05). Differential between pre- and postoperative measures for both techniques were compared, and the open group was associated with more correction than the MIS group for IMA (12.4 ± 5.3 degrees vs 9.4 ± 4.4 degrees, P = .004) and HVA (25.5 ± 8.3 degrees vs 20 ± 9.9 degrees, P = .005). Wound complication and nonunion rates trended higher in the open group (4 vs 0) ( P = .051). Conclusion: Both techniques resulted in good to excellent correction. However, the open technique was associated with lower postoperative IMA values and more correction power for IMA and HVA, than the MIS.
Vascular response to stress: Protective action of the bisphosphonate alendronate
Authors: Cutini Pablo H , Campelo Adrián E , Massheimer Virginia L 
Published: July 2022

Background: Since several additional actions of bone bisphosphonates have been proposed, we studied the effect of the bisphosphonate alendronate (ALN) on the vascular response to environmental stress. Methods: Primary cultures of endothelial cells (EC) and vascular smooth muscle cells (VSMC) exposed to strained conditions were employed for experimental evaluation. After ALN treatment, cell migration, proliferation, and angiogenesis assays were performed. The participation of signal transduction pathways in the biochemical action of ALN was also assessed. Results: In VSMC cultures, ALN counteracted the stimulation of cellular migration elicited by the proinflammatory agent lipopolysaccharide (LPS) or by high levels of calcium and phosphorus (osteogenic medium). Indeed, ALN reduced the increase of VSMC proliferation evoked by the stressors. When LPS and osteogenic medium were added simultaneously, the enhancement of cell proliferation dropped to control values in the presence of ALN. The mechanism of action of ALN involved the participation of nitric oxide synthase, mitogen-activated protein kinase (MAPK), and protein kinase C (PKC) signaling pathways. The study revealed that ALN exhibits a proangiogenic action. On EC, ALN enhanced vascular endothelial growth factor (VEGF) synthesis, and induced capillary-like tube formation in a VEGF-dependent manner. The presence of vascular stress conditions (LPS or osteogenic medium) did not modify the proangiogenic action elicited by ALN. Conclusion: The findings presented suggest an extra-bone biological action of ALN, which could contribute to the maintenance of vascular homeostasis avoiding cellular damage elicited by environmental stress.
A randomized, controlled trial on fenofibrate in primary biliary cholangitis patients with incomplete response to ursodeoxycholic acid
Authors: Li Chunlei , Zheng Kunyu , Chen Yiran , He Chengmei , Liu Suying , Yang Yunjiao , Li Mengtao , Zeng Xiaofeng , Wang Li , Zhang Fengchun 
Published: July 2022

Introduction: About one-third of primary biliary cholangitis (PBC) patients do not exhibit complete response to ursodeoxycholic acid (UDCA). Some of these patients were reported to benefit from the combination therapy of fibrates and UDCA, but more clinical evidence is required. In this study, we conducted a randomized, controlled trial on the safety and efficacy of fenofibrate in the treatment of patients with PBC. Methods: Forty-eight PBC patients with incomplete response to UDCA were enrolled and randomly assigned to two groups (24 in the experiment group and 24 in the control group). For the experimental group, the patients were administered 13–15 mg/kg/day UDCA in combination with 200 mg/day fenofibrate. For the control group, the patients continued to receive UDCA at 13–15 mg/kg/day. The patients were followed up for at least 12 months. The serum levels of alkaline phosphatase (ALP), gamma-glutamyl transferase (γ-GT), aspartate aminotransferase (AST), and other biochemical parameters were measured at 3, 6, and 12 months during the trial to assess patient conditions. Results: At 12 months, 20.8% of the patients in the experimental group had all three indexes of serum ALP, γ-GT, and total bilirubin normalized, while 0% of patients in the control group reached the primary outcome (difference, 20.8 percentage points; 95% CI, 4.6–37.0). 54.2% of the patients had normal ALP levels in the experimental group and 4.2% in the control group (difference, 50 percentage points; 95% CI, 28.5–71.5). The experimental group had greater improvement of ALP ( p < 0.001) and IgG ( p = 0.026) than the control group. The biochemical indexes of the patients in the experimental group also significantly improved during the treatment of fenofibrate. Conclusion: Addition of fenofibrate can improve biochemical indexes of PBC patients who had an incomplete response to UDCA. Reversible elevation of serum creatine and transaminases is observed in some patients. The trial was registered in the Chinese Clinical Trial Registry (ChiCTR) as ChiCTR1800020160 (protocol available online: http://www.chictr.org.cn/showproj.aspx?proj=32443 ).
Prophylactic administration of HPA-1a–specific antibodies prevents fetal/neonatal alloimmune thrombocytopenia in mice
Authors: Zhi Huiying , Sheridan Douglas , Newman Debra K. , Newman Peter J. 
Published: July 2022

Abstract
Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening bleeding disorder caused by maternal alloantibodies directed against paternally inherited human platelet alloantigens (HPAs) present on the surface of fetal and neonatal platelets. There are currently no approved therapies for the prevention of FNAIT. We report herein the ability of 2 human HPA-1a–specific therapeutic candidates, one a polyclonal, and the other a monoclonal antibody, to prevent alloimmunization in a novel preclinical mouse model of FNAIT. Both antibody preparations effected the rapid and complete elimination of HPA-1a+ platelets from circulation and prevented the development of HPA-1a alloantibodies. HPA-1a− female mice treated prophylactically with anti–HPA-1a antibody prior to exposure to HPA-1a+ platelets gave birth to HPA-1a+/− pups with significantly improved platelet counts and no bleeding symptoms. These preclinical data establish both the potential and threshold exposure targets for prophylactic treatment with HPA-1a–specific antibodies for the prevention of FNAIT in humans.