bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling wind drift and evaporation losses during sprinkler irrigation in arid areas (case of Touggourt - Algeria)
Authors: Gheriani Sofiane , MEZA Noureddine , BOUTOUTAOU Djamel 
Published: January 2022

Abstract
In recent years, agriculture development in South-eastern Algeria progressed rapidly which increased the demand for agricultural products. Given that this region is characterized by hard agro-climatic conditions, irrigation seems to be a necessary factor for ensuring optimal development and high agricultural production. Like many irrigation technics widely used, sprinkler irrigation performance was considerably affected by these conditions, mainly evaporation, which causes water losses. This study aims to propose an adequate mathematical model predicting wind drift and evaporation losses under different weather conditions resume by the complex indicator of climatic intensity (ɸ). Results showed that complex indicators of climatic intensity, were significant factors affecting the wind drift and evaporation losses, puissance relationship between wind drift and evaporation losses, and complex indicators of climatic intensity, obtained model are adopted can be useful tools in the determination of the overall losses in terms of environmental conditions (air temperature, relative humidity, and wind speed). Totally 25 measure samples were used for training the model, and 15 measure samples for testing and validation of the model. The developed model for the WDEL modeling shows high good performance with a coefficient of determination (R2) = 0.808, mean squared error (RMSE) = 3.39%, and Mean Absolute Error MAE = 8.41%.
Exploring Polycrystalline Materials: High-throughput Phase Elucidation Using Serial Rotation Electron Diffraction
Authors: Luo Yi , Wang Bin , Smeets Stef , Sun Junliang , Yang Weimin , Zou Xiaodong 
Published: January 2022

Abstract
Rapidly and reliably elucidating the phases in polycrystalline materials is essential for developing new materials. Yet, crystals of many materials of chemical, pharmaceutical, or industrial interest are too small for routine X-ray diffraction analysis. This can be workflow bottlenecks in material development, especially in high-throughput synthesis screenings. With the increased prevalence of electron diffraction, we explore a series of zeolite syntheses, resulting in polycrystalline products, via high-throughput phase identification using serial rotation electron diffraction (SerialRED). Five zeolite phases were identified in one product, the most complex mixture ever discovered in zeolite chemistry. Some of the phases are of ultra-low contents, similar unit cells, and/or identical morphologies. Via automatically examining hundreds of crystals, SerialRED enables the reliable and high-throughput phase analysis of products that X-ray diffraction cannot handle. It allows the exploration of more complex synthesis systems and provides new opportunities for rapidly developing novel materials, greatly benefiting synthesis chemistry and material science.
Investigation of The Driving Factors of Ecological Footprint in Malaysia
Authors: Kalmaz Demet Beton , Awosusi Abraham Ayobamiji 
Published: January 2022

Abstract
Malaysia’s growing trends in energy production related emissions throw doubt on the country's possibility of meeting the Paris Climate Change Agreement and SDG obligations. Taking into account Malaysia’s current growth pattern and climatic circumstances, this study evaluates the association between ecological footprint and its potential determinants: economic growth, oil consumption, renewable energy and domestic capital investment for the period between 1965 and 2017. The stationary nature of the parameters is investigated using the conventional unit root approach (ADF and PP unit root) and structural break unit root (ZA unit root). The bounds approach in combination with the critical approximation p-values of Kripfganz and Schneider (2018) established a cointegration association between the observed parameters. The ARDL approach uncovered that economic growth and oil consumption contribute to ecological footprint. Furthermore, renewable energy consumption and gross capital formation reduce the ecological footprint. The FMOLS and DOLS estimators were applied as the sensitivity analysis of the ARDL estimators. Furthermore, the spectral BC causality approach was also utilized to investigate the causal association between ecological footprint and its determinants.
Satellite-Based Precipitation Estimates Validation Using Surface Stations in the Central Region of the State of São Paulo, From 1981 to 2019
Authors: Santos Bruno César dos , Sanches Rafael Grecco , Bolleli Talyson de Melo , de Souza Paulo Henrique , Bourscheidt Vandoir 
Published: January 2022

Abstract
With the advance of remote sensing technologies, meteorological satellites have become an alternative in the process of monitoring and measuring meteorological variables, both spatially and temporally. The present study brings some additional elements to the validation of satellite-based precipitation estimates by evaluating the CHIRPS (Climate Hazards Group Infra-Red Precipitation with Station) monthly product for the central region of the state of São Paulo, Brazil, in the period 1981-2019. Initially, the general relationship between satellite estimates and surface rainfall data is assessed using the linear adjustment and error analysis in both temporal and spatial perspectives, followed by a trend analysis using Laplace test. The monthly map analysis showed a better performance of CHIRPS during the dry period (April to August) than for the wet period (October to March). Finally, monthly trends showed, in general, the same pattern of variability in rainfall over 38 years and a prevalence toward the reduction of rainfall. In summary, CHIRPS product seems a reasonable alternative for regions that lack historical rainfall information.
Real-World Prescribing Pattern of Asthma Management in China: A Retrospective, Descriptive Analysis
Authors: Sun Jian , Wang Xin , Ma Xiaobin , Feng Yuyu , Wang Yajun , Wang Junren , Jiang Shujuan , Xing Chunyan 
Published: January 2022

Abstract
Background

Asthma is a chronic inflammatory disorder of the airway that requires long-term medication management.
Objective

To describe the real-world prescribing patterns for asthma management in the Chinese population.
Methods

A retrospective analysis of 8,732 patients from January 2011 to September 2019 in 10 hospitals was conducted. Prescribing patterns of short-acting beta-agonists (SABA), long-acting beta-agonists (LABA), inhaled corticosteroids (ICS), intravenous corticosteroids, antihistamines, leukotriene receptor antagonists (LTRA), theophylline, antibiotics, and Chinese patent medicines were included in the analysis. Chi-square and logistic regression were calculated. P value of <0.05 was considered as statistical significance.
Results

ICS/LABA were prescribed for 2,940 (33.67%) patients with stable asthma and 141 (31.4%) patients with asthma exacerbations. LTRA was prescribed in 2,006 (22.97%) patients with stable asthma, and 86 (19.15%) patients with asthma exacerbations. Systemic antibiotics (46.1Z%), systemic corticosteroids (57.91%), and theophylline (51.45%) were frequently prescribed during exacerbations. A total of 5,766 patients (64.95%) were managed with traditional Chinese medication (TCM); 3237 patients (36.47%) received western medicine. Patients using ICS/LABA (P=0.019) and SABA (P=0.008) had a significantly lower rate of asthma exacerbations.
Conclusions

This study provides valuable insight into clinical practices of asthma management in China. Poor adherence to clinical reports was identified. Efforts are required to improve the quality of asthma care.
Reverse-Zoonotic Transmission of SARS-CoV-2 Lineage Alpha (B.1.1.7) to Great Apes and Exotic Felids in a Zoo in the Czech Republic
Authors: Nagy Alexander , Stara Martina , Vodička Roman , Černíková Lenka , Jiřincová Helena , Křivda Vlastimil , Sedlák Kamil 
Published: January 2022

Abstract
We report an outbreak of SARS-CoV-2 lineage alpha in gorillas and felid species in a zoo in Prague, Czech Republic. The course of illness and clinical signs are described, and the particular SARS-CoV-2 variants are characterized by next generation sequencing and phylogenetic analysis. The putative transmission routes are also inferred.
Ultrasound-Guided Lumbar Plexus Block Reduces Emergence Agitation in Children Undergoing Hip Surgery: A Prospective Randomized Controlled Trial
Authors: Zhang Hui , Zhang Junfeng , Wang Xiaofeng , Xu Tao , Yan Hai , Yang Yonggang , Chen Yongzhu , Jiang Wei , Fan Qing , Wang Aizhong 
Published: January 2022

Abstract
Background
Emergence agitation (EA) is a common and challenging postoperative problem in children emerging from general anesthesia. It is associated with self-injury, increases stress on healthcare team members and postoperative maladaptive behavioral changes. However, no completely effective prevention has been found for EA. Pain is considered to be an important contributor to EA. Ultrasound-guided lumbar plexus block is a safe and effective anesthetic technique that can provide satisfactory pain relief in pediatric hip surgery. We aim to investigate the effect of ultrasound-guided lumbar plexus block on emergence agitation in children undergoing hip surgery.
Methods
This prospective, randomized, controlled study was conducted in children aged 1-6 yr undergoing elective hip surgery. Subjects were randomly assigned to receive either ultrasound-guided lumbar plexus block combined with general anesthesia (Group Block, n=60) or routine general anesthesia (Group Control, n=60). The primary outcome was the incidence of EA at 30 min after emergence from general anesthesia, assessed using the Pediatric Anesthesia Emergence Delirium (PAED) scale. The secondary outcomes included the incidence of severe EA, postoperative pain evaluated by the Children’s Hospital of eastern Ontario Pain Scale (CHEOPS) and the incidence of postoperative adverse complications. PAED, CHEOPS were measured at 0, 5, 10, 20, and 30 min after emergence from anesthesia.
Results
The incidence of EA was significantly lower in Group Block than in Group Control [13.3% vs. 43.3%, odds ratio (OR) 0.201, 95% confidence interval (CI) 0.082to 0.496, p<0.001]. Group Block had a lower incidence of severe EA than Group Control [3.3% vs. 18.3%, odds ratio (OR) 0.154, 95% confidence interval (CI) 0.032 to 0.727, p=0.019]. CHEOPS was lower in Group Block than in Group Control [mean (95%CI), 4.5(4.4-4.6) vs.4.9 (4.8-5.0), p<0.001].
Conclusion
Ultrasound-guided lumbar plexus block could decrease the incidence and severity of emergence agitation in children undergoing hip surgery effectively.
Trial registration:
Chinese Clinical Trial Registry: ChiCTR-INR-17011525 (30/05/2017)
Comprehensive Characterization And Clinical Relevance of CLEC4G Expression Across Human Cancers
Authors: Li Yong , Huang Huiqin , Ye Xiangli , Li Xiaoping , Huang Zhenghui , Gong Longlong , Wu Feng 
Published: January 2022

Abstract
Liver and lymph node sinusoidal endothelial cell C-type lectin (CLEC4G) interacts with the surface glycoproteins of enveloped viruses and mediates immune evasion for viruses. Recent studies have indicated that the expression of CLEC4G affects the development and microenvironment of tumors. In the present study, we revealed comprehensive characterization of CLEC4G expression across human cancers. We first explored the effect of CLEC4G expression on overall survival (OS) across human cancers. High expression of CLEC4G was beneficial in lung adenocarcinoma (LUAD) and detrimental in kidney renal clear cell carcinoma (KIRC) and uveal melanoma (UVM) in terms of OS. Enrichment analysis of the 14 cancer-related signatures suggested that CLEC4G regulated tumor metastasis and immune response. Enrichment analysis of the immunophenotypes and cancer-immunity cycles indicated that CLEC4G was involved in regulation of macrophages and Treg cells, which affected tumor immune response. We also observed correlations between CLEC4G expression and checkpoint molecular expression in different cancer types. Taken together, the present study revealed the comprehensive characterization of CLEC4G expression across human cancers, predicting the roles of CLEC4G in the development and immune microenvironment of tumors.
Does the Conjunctivochalasis Accompanied by Pseudoexfoliation Syndrome Affect the Ocular Surface and Anterior Segment Structures?
Authors: Özen Bediz , Öztürk Hakan 
Published: January 2022

Abstract
Purpose: Probability of coexistence of conjunctivochalasis and pseudoexfoliation syndrome (PES) in same individual may increase with aging. We investigated effects of conjunctivochalasis accompanied by PES on ocular surface (OS) and anterior segment (AS) structures.Methods: Cases with only conjunctivochalasis were determined as group-1 (n=62), cases with conjunctivochalasis accompanied by PES as group-2 (n=45), and healthy cases as group-3 (n=56). OS and AS parameters of groups were compared.Results: Compared to group-1, group-2 had higher grade-3 conjunctivochalasis (17.7% vs 46.7%, p=0.039), greater mean grade of conjunctivochalasis (MGC) (1.72±0.24 vs 2.29±0.32, p=0.036), higher total conjunctivochalasis score (TCS) (4.27±1.13 vs 6.12±1.35, p=0.025), shorter tear-film break-up time (TBUT) (9.17±2.53 vs 5.41±1.32, p=0.010), greater OS disease index (OSDI)-score (16.28±3.15 vs 27.36±4.12, p=0.037). Compared to group-3, both group-1 and group-2 had shorter TBUT (group 3-1: p=0.004; group 3-2: p<0.001) and greater OSDI score (group 3-1: p=0.042; group 3-2: p=0.019). Schirmer tests, central corneal thicknesses, keratometries, axial lengths, anterior chamber depths and lens thicknesses of groups were similar (p>0.05). In group-1 and group-2, as age increased, both MGC (r=0.349, p=0.043; r=0.403, p=0.022, respectively) and TCS (r=0.322, p=0.046; r=0.372, p=0.031) increased. In group-2, as both MGC and TCS increased, TBUT (r=-0.370, p=0.034; r=-0.401, p=0.025) decreased and OSDI score (r=0.338, p=0.045; r=0.362, p=0.040) increased.Conclusions: To our knowledge, this was the first study comprehensively investigating effects of conjunctivochalasis accompanied by PES on OS and AS structures together. We found that conjunctivochalasis might cause OS disease, while presence of PES in conjunctivochalasis cases might worsen OS disease and conjunctivochalasis findings.
Association Between Depression and Breast Cancer: TNF/TNFRSF1β and LEP/LEPR Axis
Authors: Lin Jiaying , Cui Guangman , Jiang Wenwei , Lin Zhousheng , Lan Xinyue , Zhou Dan , Yao Guangyu 
Published: January 2022

Abstract
Depression contributes to enhanced initiation, development and metastasis of breast cancer. Despite epidemiological studies and experimental data suggest that depression and breast cancer may share a common biological mechanism, the results from these studies remain inconsistent. Here, we fully focus on the underlying biological mechanism behind the adverse effects of depression against breast cancer patients, and highlight the practical therapeutic intervention and improving quality of life. Publicly available datasets deposited in the Gene Expression Omnibus (GEO) were downloaded. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses of the differentially expressed genes (DEGs), which were extracted by using R tools, were performed. The protein-protein interaction network of the target DEGs was constructed using Cytoscape software and the hub genes were identified. In our study, we found that genes encoding proinflammatory cytokine, such as IL-1β and TNF, had significantly increased expression in depression. Following chronically stimulated by TNFα and IL-1β (usually for 14-18 days), inflammatory cancer-associated fibroblasts (CAFs) had elevated expression of inflammatory genes. Furthermore, the TNF/TNFRSF1β and LEP/LEPR regulatory axes were proven to be hub pathways of the crosstalk between depression and breast cancer. Our findings demonstrate that inflammatory factors are messengers linking depression and breast cancer, and provided further guidance in clinical medication.
Understanding the Dynamics of Staff Reallocation to Clinical Practice During the First Wave of COVID-19 – a Qualitative Study
Authors: Johansen Rie Laurine Rosenthal , Sørensen Anita , Jespersen Mads Seit , Mikkelsen Kamilla Hesthaven , Emme Christina 
Published: January 2022

Abstract
BackgroundDuring the COVID-19 pandemic, one responsive strategy to ensure hospital staff capacity was reallocation of staff between departments. Unpredicted factors may influence how the strategy is executed. Knowledge of potential moderating factors is essential to improve future staff contingency plans. To understand barriers and promoters of staff realloctation, this study explored the dynamics of reallocating staff from departments with low activity to clinical practice during the first wave of the COVID-19 pandemic at a 530-bed university hospital in the Capital Region of Denmark. MethodsWe used a mixed-methods explanatory design with sequential data collection and analysis. This paper primarily describes the qualitative part of the study, which consisted of six interviews with staff reallocated to clinical practice as part of the staff contingency plan, and seven interviews with leaders of departments that contributed with staff for reallocation. Data was analyzed using inductive content analysis.ResultsThe results showed that the execution of a staff contingency plan during a pandemic is influenced by a complex set of structural, perceptional, social, individual, and psychological moderating factors. Although staff felt obligated and motivated to cover shifts, their actual behavior and experience was influenced by factors such as uncertainty about tasks, family obligations, other work-related tasks, the contingency plan set-up, how the contingency plan, roles, and sense of urgency were interpreted by staff and leaders, and how the leaders prioritized tasks and staff time. Introduction to the unit and tasks, the feeling of being needed, voluntary participation, transparency, collegial sparring, and familiarity with the workplace were factors that promoted a positive experience.ConclusionsThis study identified a variety of complex moderating factors, which should be considered when hospital contingency plans are developed. The study highlights the importance of understanding how reallocated staff and leaders experience and make interpretations and adjustments to a given plan, as this may have great significance for how the contingency plan is put into practice. Future staff contingency plans should take these factors into consideration to make better use of human resources in times of a crisis and to improve staff’s experience with reallocation.
YES kinase controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis
Authors: Jin Yi , Ding Yindi , Richards Mark , Kaakinen Mika , Szymborska Anna , Rosa Andre , Baumann Elisabeth , Giese Wolfgang , Pena Andreia , Nwadozi Emmanuel , Jamalpour Maria , Holstein Katrin , Sáinz-Jaspeado Miguel , Vestweber Dietmar , Welsh Michael , Bernabeu Miguel , Franco Claudio , Eklund Lauri , Gerhardt Holger , Claesson-Welsh Lena 
Published: January 2022

Abstract
Vascular Endothelial (VE)-cadherin in endothelial adherens junctions is an essential component of the vascular barrier, critical for tissue homeostasis and implicated in progression of diseases such as cancer and eye diseases. Inhibitors of SRC cytoplasmic tyrosine kinase have been applied to suppress tyrosine phosphorylation of VE-cadherin and thereby to prevent excessive leakage, edema and high interstitial pressure. We show that the SRC-related YES tyrosine kinase rather than SRC, is localized at endothelial cell (EC) junctions. EC-specific YES deletion suppresses VE-cadherin phosphorylation, and arrests VE-cadherin at EC junctions. This is accompanied by loss of EC collective migration, and exaggerated agonist-induced macromolecular leakage, while extravasation of monocytes is suppressed. Overexpression of Yes causes ectopic VE-cadherin phosphorylation while vascular leakage is unaffected. In contrast, in EC-specific Src-deficient mice, VE-cadherin internalization is maintained and leakage is suppressed. In conclusion, YES-mediated VE-cadherin phosphorylation regulates its constitutive turnover, required for endothelial junction plasticity and vascular integrity.
Functional Outcome in Late Adolescence/ Early Adulthood of Patients With Autism Spectrum Disorder and Its Relationships With Parental Burnout and Depression: Multi-center, Cross-sectional Study
Authors: KUTUK Meryem Ozlem , TUFAN Ali Evren , KILICASLAN Fethiye , VURAL Pinar , GOKCEN Cem , GUNEY Sevay Alsen , KUTUK Bahtım , OZYURT Gonca , INAL Neslihan , MUTLUER Tuba , ACIKALIN Eren Yavuz , OZER Fadime Hande , PAMUK Esma Nur , YESILMESE Seyma Celikcan , KARADAG Mehmet , TOPAL Zehra , BILGINER Cilem , SAHIN Nilfer , BILAC Oznur , KANDEMİR Hasan , ERCAN Eyup Sabri , SOYLEMEZ Tugba Eseroglu , ACIKEL Sadettin Burak , AKSU Gulen Guler , DAG Pelin , TOROS Fevziye , MUTLU Caner , KARDAS Omer , KARDAS Burcu , KIZILDAG Suleyman , DEMIRCI Esra , OZMEN Sevgi , SEVICIN Leyla , KARAGOZ Yuksel Sumeyra , ISIK Umit , AKTEPE Evrim , ALTUN Hatice , YEKTAS Cigdem , TUYSUZ Berna Polat , BUBER Ahmet , CANSIZ Mehmet Akif , OGUTLU Hakan , ERAY Safak , TANER Hande Ayraler , ALTINTAS Ebru , KUTUK Ozgur 
Published: January 2022

Abstract
The aim of this study is to determine functioning of adults with Autism Spectrum Disorders (ASDs) diagnosed in childhood and also depression and burnout levels among their parents. 261 adults with ASDs and their parents were recruited for the study. Both parents completed the Beck Depression and Maslach Burnout Inventories and reported the functioning of their adult offspring with ASDs. Only 5.4 % of our sample reported “good” or “very good” outcome. The most common psychiatric comorbidities were intellectual disabilities and attention-deficit/ hyperactivity disorder. Maternal burnout and depression scores were significantly elevated compared to those of fathers. There is an undeniable urgent need for more research to identify the needs of adults and families suffering from ASD.