bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authors: Zakaria Amin , Nurmayunita Henny 
Published: May 2022

The implementation of the blended learning model requires the ability to wash hands for all school students as the main pillar of preventing the transmission of the corona virus-19 in the school environment. The Work From Home (WFH) policy during the pandemic has made social media as the people's choice to communicate and get health information, (Kemp, S., 2018). During the current pandemic, the School Health Business (UKS) program is minimal or not implemented at all because UKS does not yet have the media to run health education. SLBN Pembina Nasional Bagian C Lawang Malang are 65% of the types of disabilities are mentally retarded with an intelligence/IQ level below the average 3-6 levels below normal children so that students have difficulty in learning. So that students must be given creative and innovative learning media, the form resembles real or real conditions. Video is one of the health education media that is considered very appropriate for mentally retarded children. This study aims to analyze the effect of giving a 6-step hand-washing video tutorial on the ability and use of hand-washing equipment for students of SLBN Pembina Nasional Bagian C Malang. The type of the research is pre-experimental pre-posttest design, simple random sampling proportional, research variable ability and use of students' six-step handwashing equipment, checklist instrument by testing the validity of correlation product moment, Paired T-Test sample analysis in pairs with the help of SPSS. Testing the effect of giving a 6-step hand washing tutorial video on the ability to wash hands. The results showed that the significance value was 0.000 which was less than 0.05 so it can be concluded that giving a hand washing tutorial video had an effect on the hand washing ability of SLB students. Testing the effect of giving a 6 step hand washing tutorial video on the use of hand washing equipment, the result is that the significance value is 0.000 which is less than 0.05, it can be concluded that the 6 step hand washing tutorial video is given to the use of SLB students' hand washing equipment. The UKS suggestion is to use and develop video health promotion media using the Whatshap application, Youtube and increase the response and participation of students, especially parents or families.
Peran Kemampuan Pengguna Teknologi Informasi Menuju Transformasi Sumberdaya Manusia di Era Revolusi Industri 4.0
Authors: Muhardono Ari , Chalimah Chalimah , Diazwara Mahardika , Mar'ah Mar'ah 
Published: May 2022

<p>Human resources (HR) transformation is strongly guided in the industrial revolution 4.0 Era. The ability of users of information technology has an important role in the HR transformation. Therefore, this study aims to examine the effect of the application of information technology on the HR transformation with user capabilities as a moderating variable in the Savings and Loans Cooperative and Syari'ah Baitut Tamwil Muhammadiyah (KSPPS BTM) Central Java. Data collection was carried out by distributing questionnaires to the all managers of KSPPS BTM in the Central Java region. Data analysis using simple linear regression. To test for the first hypothesis and the second hypothesis using the MRA (Moderated Regression Analysis) method. The results show that the application of information technology has a positive and significant effect on HR transformation, while the moderating variable from the results of the second hypothesis test shows that the user ability variable has a positive and insignificant effect on the relationship between the application of information technology and HR transformation, but the user ability variable weakens the interaction between the variables of the application of information technology to the HR transformation. So it can be said that the user's ability is a potential moderating variable (Homologiser).</p><p> </p><p><strong>Keywords: Application of Information Technology, User Capabilities, HR Transformation, Moderating Variables</strong></p>
Case Report: Tuberculosis with Pericardial Effusion in Children
Authors: Shodikin Muhammad Ali 
Published: May 2022

Background. Tuberculosis pericardial effusion is a rare case in the developed countries. This may cause serious and deadly impact if not diagnosed and treated properly. Appropriates diagnosis and treatment of tuberculosis pericardial effusion can prevent mortality.
Case. A 14-years-old boy was admitted with tightness of breath, chest pain, and abdominal enlargement. Chest X-ray revealed heart enlargement and echocardiography showed a massive pericardial effusion. The diameter of induration of tuberculin skin test was 14 mm. This patient was diagnosed as tuberculosis pericardial effusion and showed complete recovery after paricardiocentesis and anti-tuberculosis drugs administration for 12 month.
Conclusion. Tuberculosis pericardial effusion should be remembered in cases of tightness of breath with chest x ray revealing heart enlargement. Adequate treatment by pericardiocentesis and anti-tuberculosis drugs can completely cure this disease.
The Effect of Brown Algae (Sargassum sp) Extract on Wound Healing
Authors: Bintarti Tri Wahyuni , Widyaswari Meidyta Sinantryana 
Published: May 2022

Backgroud: The wound care method that is currently developing uses the principle of moisture balance which is also known as the modern dressing method. Seaweed is a potential commodity in Indonesia, which has been widely used as a medicinal ingredient. However, the use of seaweed in the form of hydrogel ointment in the treatment of burns has not been widely studied. Therefore, this study was conducted to determine the effect of giving seaweed extract (Sargassum sp.) in the form of hydrogel ointment to burns.
Methods: The design in this study was an experimental study with a randomized post-test only control group design, using musmusculus mice. This study was divided into 4 groups, group 1 was a negative control without treatment, group 2 was a group with burns and was given bioplacenton, group 3 was a burn group treated with 5% Sargassum sp extract hydrogel ointment and group 4 was a burn group given 5% ointment. Sargassum sp extract hydrogel ointment 10%. The treatment was carried out for 14 days and evaluated the diameter of the burn and the percentage of burn healing.
Results: The results of this study showed that the difference in burn diameter at 0 days and after 14 days in the negative control group experienced a difference of 1.2 cm with a healing percentage of 44.85%. In treatment group 1, there was a difference in diameter of 1.2 cm, with a healing percentage of 49.41%, the 2-day treatment group obtained a difference in diameter of 1.2 cm, with a healing percentage of 50.31%, and in the positive control group a wound diameter of 1.0 cm, while the percentage of cure is 55.75%. The results of statistical tests on the percentage of wound healing between groups were not significantly different.
Conclusion: In this study the seaweed extract (Sargassum sp.) formed in the hydrogel ointment did ot affect the healing of burns, this may be due to the long duration of administration.
Effect of Youths Remittances on Rural Livelihoods in South Eastern Nigeria
Authors: Alleluyanatha Esther , Treasure Lilian 
Published: May 2022

This study evaluated the effect of remittances on crop productivity and household welfare in Southeastern, Nigeria. Anambra and Imo states were purposively selected for their high rate in youth migration; and 714 households were used for the study. Data was analyzed using Endogenous treatment effect model. Wealth Index Score was used as a proxy for household welfare. The results of the study showed that employment status, sex of migrant, and age of migrant, sending remittance for buying of agricultural implements as well as paying for school were the major factors that influenced sending of remittances by the youths to the originating households in the study area. Also, the average treatment effect (ATE) of remittances on household welfare was insignificant, implying that there was no significant difference between remittance and non-remittance households. However, the ATE of remittances on crop productivity was significant in the pooled states but not significant in the states. Youths should be encouraged to move into agriculture by removing the bottlenecks associated to agricultural production.
Crecimiento poblacional de las tiendas virtuales de Portoviejo y su aporte al desarrollo económico
Authors: Padilla Córdova Lilid del Rocio , Vera Zambrano Diana Sabina , Mendoza García Cristhian Andrés , Bravo Santana Verónica Piedad 
Published: May 2022

La presente investigación tiene como finalidad dar a conocer información sobre el auge y evolución de las tiendas virtuales en la ciudad de Portoviejo, Provincia de Manabí, en ella se resalta cómo nace esta tendencia, además de determinar cuál de las redes sociales es la más utilizada no solo por los emprendedores, sino por los diferentes clientes potenciales que posee el mercado electrónico. Se presentan gráficos estadísticos que demuestran el crecimiento de emprendimientos electrónicos desde el inicio de la pandemia por COVID-19 hasta el año 2021; así como los tipos de negocios, siendo estos de variados enfoques comerciales y que se han llegado a la apertura en diferentes fechas del año 2016, algunos suspendiendo estas actividades con el pasar de los años hasta el 2021, concluyendo que las tiendas virtuales que generan mayor movimiento dentro de la población de Portoviejo, es el comercio de prendas de vestir; fabricación de piezas de joyas; otras actividades profesionales, científicas y técnica; restaurantes; y venta de chatarra, aportando al desarrollo económico del cantón con relación a la generación de empleo y pago de tributos.
Optimasi Biaya Transportasi Rantai Roda Tipe-428 dengan Metode Stepping Stone dan Modified Distribution
Authors: Ilahy Rosihan Rifda , rizky Muhammad ferdiansyah dwi , Paduloh Paduloh , Saputra Yayan , Kumalasari Ratih , Spalanzani Widya , Sitorus Helena 
Published: May 2022

Ketidapastikan alokasi pendistribusian produk rantai roda tipe-428 mengakibatkan tinggi nya biaya transportasi sehingga perlu dilakukan pengoptimalan biaya tranpsortasi untuk mengurangi pemborosan. Pendistribusian produk rantai roda tipe-428 ke beberapa customer. Pendistribusian produk rantai roda tipe-428 ke beberapa customer dengan permintaan masing-masing customer yang berbeda dan jumlah yang besar dengan rata-rata permintaan terbesar customer adalah 234.609. Penelitian ini dilakukan guna menemukan solusi optimal untuk menemukan biaya transportasi yang optimal. Metode yang digunakan pada penelitian ini metode North West Corner (NWC), Least Cost, dan Vogel Approximation (VAM), dengan metode yang terpilih adalah Least Cost dan VAM karena biaya yang dihasilkan oleh kedua metode tersebut yang paling optimum dan menghasilkan total biaya yang sama. Kemudian, mencari solusi optimum dengan membandingkan biaya yang optimum menggunakan metode Stepping Stone dan metode MODI (Modified Distribution). Hasil dari pencarian solusi optimum dengan kedua metode ini didapatkan hasil yang sama sehingga dipilih metode stepping stone untuk mencari solusi optimum. Kemudian dilakukan pengecekan dengan menggunakan software LINGO untuk mengetahui hasil yang didapatkan dari perhitungan manual sudah sesuai. Dari hasil perhitungan yang dilakukan didapatkan penurunan biaya sebesar 33,17%.
The Imbalance of Cytokines and Lower Levels of Tregs in Elderly Male Primary Osteoporosis
Authors: Zhang Wei , Zhao Wei , Li Wei , Geng Qi , Zhao Rui , Yang Yungui , Lv Luyan , Chen Weiwen 
Published: May 2022

IntroductionOsteoporosis (OP) is a debilitating disease that brings a heavy burden to individuals and society with reduced quality of life and lifespan. However, it’s frequently overlooked and poorly studied in elderly male patients. Worse still, few anti-osteoporosis drugs are effective at the prevention and treatment of osteoporosis in men. It has been reported that the cells of bone and the immune system share common progenitors, cytokines and growth factors, and that reciprocal interactions occur during health and disease. Nevertheless, the role of immune system in OP is not fully understood, especially in male patients. Therefore, this study aimed to investigate molecular alterations in immune cells in men with OP and to identify immunomodulatory strategies with potential therapeutic value.Materials and MethodsA population of 121 men aged between 51 and 80 years old was recruited. Bone mineral density (BMD) was measured at the lumbar spine L1-4 and femoral neck using dual-energy X-ray absorptiometry (DXA). Twenty people were healthy, 66 people had osteopenia and 35 people had OP. Bone metabolic markers, Th1, Th2, Tregs and immune molecules were evaluated at the time of enrollment.ResultsSmoking was a risk factor for OP. C-terminal crosslinking of type I collagen (β-CTX) and the ratio of receptor activator of nuclear factor-κB ligand (RANKL) to osteoprotegerin (OPG) were higher in OP group, which had lower 25-hydroxyvitamin D [25(OH)D] levels. OP had the higher levels of IL-6 and TNF-α and lower levels of IFN-γ and IL-10. CD4+CD25+CD127-/low Tregs were significantly lower in the OP group. The imbalance of Th1/Th2 cells may play an important role in the development of OP. 25(OH)D may play essential roles in maintaining bone health. The low level of Tregs is also one of the underlying immune mechanism that leads to male primary OP.ConclusionThe active function of osteoclasts and the decline in osteoblasts were characteristics of OP, and the imbalance in cytokines and lower levels of Tregs were observed in elderly male patients with primary OP.
Coexistence of blaNDM-1 and blaIMP-4 in One Novel Hybrid Plasmid Confers Transferable Carbapenem Resistance in an ST20-K28 Klebsiella pneumoniae
Authors: Jia Xinmiao , Jia Peiyao , Zhu Ying , Yu Wei , Li Xue , Xi Jingyuan , Liu Xiaoyu , Liao Kang , Xu Yingchun , Cheng Bin , Yang Qiwen 
Published: May 2022

ObjectivesWe identified a novel hybrid plasmid simultaneously carrying blaNDM-1 and blaIMP-4 in an ST20-K28 carbapenem-resistant Klebsiella pneumoniae (CRKP) strain AZS099 and reported its detailed genetic and phenotypic characterization.MethodsAntimicrobial susceptibility was characterized using broth microdilution method. Complete genome characteristics and plasmid detailed analysis were carried out by PacBio Sequel and Illumina sequencing and further bioinformatics analysis. Conjugation assay, S1-PFGE, Southern blot, plasmid stability, and fitness cost were conducted to the phenotypic characterization of this novel hybrid plasmid.ResultsAZS099 was isolated from a blood specimen obtained from a 3-month baby who presented with biliary tract infection. Susceptibility testing showed that AZS099 was resistant to almost all β-lactams examined, including cephalosporins, combinations of β-lactams and β-lactamase inhibitors, carbapenems, and aztreonam. PacBio and Illumina sequencing together with S1-PFGE and Southern blot showed that blaNDM-1 and blaIMP-4 were simultaneously located on a 296 kb IncFIB(K)/IncHI1B/IncX3 plasmid (pAZS099-NDM-IMP), which consists of four main parts that came from four different types of plasmids. The region harboring blaIMP-4 is located in a class 1 integron designated as In0, which is located in an IS6100-IS26 transposon-like structure with a total length of ~5 kb. The region harboring blaNDM-1 is located in the Tn125 transposon remnant. Conjugation and transformation assay confirmed that the plasmid pAZS099-NDM-IMP has the potential for horizontal transfer and displayed high stability (retention rate &gt; 95%). Furthermore, growth curve assessment confirmed that the presence of pAZS099-NDM-IMP exhibits no growth pressure on bacteria.ConclusionOur research reported a hybrid plasmid coharboring blaNDM-1 and blaIMP-4 in an ST20-K28 CRKP strain. The emergence of novel hybrid plasmid could threaten the control of antimicrobial resistance and should be closely supervised.
Radiomics Nomogram in Assisting Lymphadenectomy Decisions by Predicting Lymph Node Metastasis in Early-Stage Endometrial Cancer
Authors: Liu Xue-Fei , Yan Bi-Cong , Li Ying , Ma Feng-Hua , Qiang Jin-Wei 
Published: May 2022

BackgroundLymph node metastasis (LNM) is an important risk factor affecting treatment strategy and prognosis for endometrial cancer (EC) patients. A radiomics nomogram was established in assisting lymphadenectomy decisions preoperatively by predicting LNM status in early-stage EC patients.MethodsA total of 707 retrospective clinical early-stage EC patients were enrolled and randomly divided into a training cohort and a test cohort. Radiomics features were extracted from MR imaging. Three models were built, including a guideline-recommended clinical model (grade 1-2 endometrioid tumors by dilatation and curettage and less than 50% myometrial invasion on MRI without cervical infiltration), a radiomics model (selected radiomics features), and a radiomics nomogram model (combing the selected radiomics features, myometrial invasion on MRI, and cancer antigen 125). The predictive performance of the three models was assessed by the area under the receiver operating characteristic (ROC) curves (AUC). The clinical decision curves, net reclassification index (NRI), and total integrated discrimination index (IDI) based on the total included patients to assess the clinical benefit of the clinical model and the radiomics nomogram were calculated.ResultsThe predictive ability of the clinical model, the radiomics model, and the radiomics nomogram between LNM and non-LNM were 0.66 [95% CI: 0.55-0.77], 0.82 [95% CI: 0.74-0.90], and 0.85 [95% CI: 0.77-0.93] in the training cohort, and 0.67 [95% CI: 0.56-0.78], 0.81 [95% CI: 0.72-0.90], and 0.83 [95% CI: 0.74-0.92] in the test cohort, respectively. The decision curve analysis, NRI (1.06 [95% CI: 0.81-1.32]), and IDI (0.05 [95% CI: 0.03-0.07]) demonstrated the clinical usefulness of the radiomics nomogram.ConclusionsThe predictive radiomics nomogram could be conveniently used for individualized prediction of LNM and assisting lymphadenectomy decisions in early-stage EC patients.
Case Report: A Novel Intronic Mutation in AIFM1 Associated With Fatal Encephalomyopathy and Mitochondrial Disease in Infant
Authors: Peng Qi , Ma Keze , Wang Linsheng , Zhu Yinghua , Zhang Yaozhong , Rao Chunbao , Luo Dong , Jiang Zaixue , Lai Wei , Lu Huiling , Duan Chaohui , Zhou Zhongjun , Lu Xiaomei 
Published: May 2022

BackgroundThe AIFM1 gene is located on chromosome Xq26.1 and encodes a flavoprotein essential for nuclear disassembly in apoptotic cells. Mutations in this gene can cause variable clinical phenotypes, but genotype-phenotype correlations of AIFM1-related disorder have not yet been fully determined because of the clinical scarcity.Case PresentationWe describe a 4-month-old infant with mitochondrial encephalopathy, carrying a novel intronic variant in AIFM1 (NM_004208.4: c.1164 + 5G &gt; A). TA cloning of the complementary DNA (cDNA) and Sanger sequencing revealed the simultaneous presence of an aberrant transcript with exon 11 skipping (89 bp) and a normal transcript through analysis of mRNA extracted from the patient’s fibroblasts, which is consistent with direct RNA sequencing results.ConclusionWe verified the pathogenic effect of the AIFM1 c.1164 + 5G &gt; A splicing variant, which disturbed normal mRNA splicing. Our findings expand the mutation spectrum of AIFM1 and point out the necessity of intronic sequence analysis and the importance for integrative functional studies in the interpretation of sequence variants.
Morning Exercise Reduces Abdominal Fat and Blood Pressure in Women; Evening Exercise Increases Muscular Performance in Women and Lowers Blood Pressure in Men
Authors: Arciero Paul J. , Ives Stephen J. , Mohr Alex E. , Robinson Nathaniel , Escudero Daniela , Robinson Jake , Rose Kayla , Minicucci Olivia , O’Brien Gabriel , Curran Kathryn , Miller Vincent J. , He Feng , Norton Chelsea , Paul Maia , Sheridan Caitlin , Beard Sheriden , Centore Jessica , Dudar Monique , Ehnstrom Katy , Hoyte Dakembay , Mak Heather , Yarde Aaliyah 
Published: May 2022

The ideal exercise time of day (ETOD) remains elusive regarding simultaneous effects on health and performance outcomes, especially in women.Purpose: Given known sex differences in response to exercise training, this study quantified health and performance outcomes in separate cohorts of women and men adhering to different ETOD.Methods: Thirty exercise-trained women (BMI = 24 ± 3 kg/m2; 42 ± 8 years) and twenty-six men (BMI = 25.5 ± 3 kg/m2; 45 ± 8 years) were randomized to multimodal ETOD in the morning (0600–0800 h, AM) or evening (1830–2030 h, PM) for 12 weeks and analyzed as separate cohorts. Baseline (week 0) and post (week 12) muscular strength (1-RM bench/leg press), endurance (sit-ups/push-ups) and power (squat jumps, SJ; bench throws, BT), body composition (iDXA; fat mass, FM; abdominal fat, Abfat), systolic/diastolic blood pressure (BP), respiratory exchange ratio (RER), profile of mood states (POMS), and dietary intake were assessed.Results: Twenty-seven women and twenty men completed the 12-week intervention. No differences at baseline existed between groups (AM vs PM) for both women and men cohorts. In women, significant interactions (p &lt; 0.05) existed for 1RM bench (8 ± 2 vs 12 ± 2, ∆kg), pushups (9 ± 1 vs 13 ± 2, ∆reps), BT (10 ± 6 vs 45 ± 28, ∆watts), SJ (135 ± 6 vs 39 ± 8, ∆watts), fat mass (−1.0 ± 0.2 vs −0.3 ± 0.2, ∆kg), Abfat (−2.6 ± 0.3 vs −0.9 ± 0.5, ∆kg), diastolic (−10 ± 1 vs−5 ± 5, ∆mmHg) and systolic (−12.5 ± 2.7 vs 2.3 ± 3, mmHg) BP, AM vs PM, respectively. In men, significant interactions (p &lt; 0.05) existed for systolic BP (−3.5 ± 2.6 vs −14.9 ± 5.1, ∆mmHg), RER (−0.01 ± 0.01 vs −0.06 ± 0.01, ∆VCO2/VO2), and fatigue (−0.8 ± 2 vs −5.9 ± 2, ∆mm), AM vs PM, respectively. Macronutrient intake was similar among AM and PM groups.Conclusion: Morning exercise (AM) reduced abdominal fat and blood pressure and evening exercise (PM) enhanced muscular performance in the women cohort. In the men cohort, PM increased fat oxidation and reduced systolic BP and fatigue. Thus, ETOD may be important to optimize individual exercise-induced health and performance outcomes in physically active individuals and may be independent of macronutrient intake.