bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study of lipolysis induced by adjuncts from edible Aspergillus sp. solid culture products on ripened semi‐hard cheese
Authors: Chintagavongse Napaporn , Takiguchi Hayate , Ming‐Hsuan Chi , Tamano Koichi , Hayakawa Toru , Wakamatsu Jun‐ichi , Mitani Tomohiro , Kumura Haruto 
Published: January 2022

AbstractBACKGROUNDAspergillus sp. has been used in traditional Japanese fermented foods. Protease‐containing culture products of A. oryzae have been applied as the adjunct enzyme source to enrich the flavor in ripened cheese. Although proteolysis was stimulated, the increase of free fatty acids (FFA) was recognized in some products. Since an excess amount of FFA accumulation can cause rancidity in cheese products, the assessment of lipase activity was considered to be essential for the cheese adjunct preparation.RESULTSAlthough an equal lipase activity from the adjunct materials of A. kawachii NBRC 4308, A. luchuensis RIB 2604 and A. oryzae AHU 7139 was applied to semi‐hard cheese, the FFA level was significantly higher in A. oryzae cheese than in the others. Furthermore, the profiles of volatile components were different in experimental cheeses. An in vitro study with experimental curds demonstrated that the high FFA might not depend on the lipase retainability on curds. On the contrary, the pronounced activation of the lipases occurred in A. oryzae after incubation with the curds. Moreover, incubation of the insoluble lipase that had been attached to the cells with skim milk curd extracts allowed the release of lipases from the cells into the medium with remarkable activation.CONCLUSIONA. oryzae AHU 7139 possessed a complex lipolytic system comprising extracellular and cell‐binding lipases that were attributed to the increase in FFA in A. oryzae cheese. © 2022 Society of Chemical Industry.
ROS‐Sensitive Polymer Micelles for Selective Degradation in Primary Human Monocytes from Patients with Active IBD
Authors: Gardey Elena , Sobotta Fabian H. , Quickert Stefanie , Bruns Tony , Brendel Johannes C. , Stallmach Andreas 
Published: January 2022

AbstractInflammatory bowel disease (IBD) is characterized by increased levels of reactive oxygen species (ROS) in inflamed areas of the gastrointestinal tract and in circulating immune cells, providing novel opportunities for targeted drug delivery. In the recent experiments, oxidation‐responsive polymeric nanostructures selectively degrade in the presence of H2O2. Based on these results, it is hypothesized that such degradation process can be triggered in a similar way by the incubation with stimulated monocytes isolated from patients with IBD. A first indication is given by a significant correlation between excessive ROS and degradation of micelles in monocytes isolated from healthy individuals after phorbol 12‐myristate 13‐acetate (PMA) stimulation. But even if the ROS‐sensitive micelles are incubated with nonstimulated monocytes from patients with active IBD, a spontaneous degradation is observed in contrast to micelles incubated with monocytes from healthy donors. The findings indicate that the thioether‐based micelles are indeed promising for selective drug release in the presence of activated immune cells.
Long-term masticatory performance and ability following closed treatment for unilateral mandibular condylar neck or base fractures: a cross-sectional study
Authors: Weinberg Florine M. , Rosenberg Antoine J. W. P. , Muller Barbara S. , Speksnijder Caroline M. 
Published: January 2022

Abstract
Purpose
The aim of this study was to find explanatory variables for objective and patient-reported long-term masticatory functioning in patients treated with maxillomandibular fixation for unilateral condylar neck or base fractures. These outcomes were compared to healthy control subjects.

Methods
Patients treated between 1996 and 2013 were enrolled in the study. Objective measurements included the mixing ability test (MAT) for masticatory performance, and range of motion of the mandible. Patient-reported measurements included the mandibular function impairment questionnaire (MFIQ) for masticatory ability, and the visual analogue scale for pain. Healthy subjects were recruited between October 2018 and January 2019, and performed the MAT and MFIQ.

Results
Twenty-one patients and 30 healthy subjects were included. The average follow-up period was 11.67 years. In adjusted regression analysis, the amount of occlusal units (OU) was associated with the MAT (P = 0.020; R2 = 0.253) and MFIQ (P = 0.001, R2 = 0.454). The MAT outcome was similar in both groups when correcting for OU (P = 0.001; R2 = 0.201). The MFIQ was inferior in the patient group (P = 0.001).

Conclusion
Long-term masticatory performance was similar in patients with a history of condylar neck or base fracture and healthy subjects; however, masticatory ability was inferior in patients compared to healthy subjects.
Moral Dilemmas in Foster Care Due to Religious Differences Between Birth Parents, Foster Parents, and Foster Children
Authors: van Bergen Diana D. , Saharso Sawitri , Degener Clementine J. , Bartelink Brenda E. , Vanderfaeillie Johan 
Published: January 2022

AbstractMany ethnoreligious-minority foster children in several western countries, including the Netherlands, are placed and permanently live with ethnically and religiously non-matched foster families (i.e., in trans-religious foster care). We examine whether and which moral dilemmas exist around the issue of how religion should be weighted in trans-religious foster care to provide ethnoreligious-minority foster children with healthy identity development. We applied a thematic analysis to 17 qualitative interviews (seven foster parent/foster child dyads and three foster parents) taken from two pre-existing datasets. We retrieved five moral dilemmas in trans-religious foster care placements, which are discussed in relation to the following ethical arguments: (1) pressure from birth parents and parents of foster children to abide by their religious praxis; (2) objections of the foster family to the faith of the birth family; (3) a switch to the faith of the foster family by the foster child; (4) challenges to the religious identity searches of foster children due to ethnoreligious boundary drawing between majority and minority groups; and (5) the impact of religious traditions on the bodily integrity of foster children. We argue that it is in the best interest of foster children to have a foster family who, when making (some) religious choices on their behalf, is sensitive to the particular child and their developing identity with regard to their religious ideas and beliefs. Foster families need support regarding religious reflection and religious self-determinism in their foster children.
Digital Rock Reconstruction with User-Defined Properties Using Conditional Generative Adversarial Networks
Authors: Zheng Qiang , Zhang Dongxiao 
Published: January 2022

AbstractUncertainty is ubiquitous with multiphase flow in subsurface rocks due to their inherent heterogeneity and lack of in-situ measurements. To complete uncertainty analysis in a multi-scale manner, it is a prerequisite to provide sufficient rock samples. Even though the advent of digital rock technology offers opportunities to reproduce rocks, it still cannot be utilized to provide massive samples due to its high cost, thus leading to the development of diversified mathematical methods. Among them, two-point statistics (TPS) and multi-point statistics (MPS) are commonly utilized, which feature incorporating low-order and high-order statistical information, respectively. Recently, generative adversarial networks (GANs) are becoming increasingly popular since they can reproduce training images with excellent visual and consequent geologic realism. However, standard GANs can only incorporate information from data, while leaving no interface for user-defined properties, and thus may limit the representativeness of reconstructed samples. In this study, we propose conditional GANs for digital rock reconstruction, aiming to reproduce samples not only similar to the real training data, but also satisfying user-specified properties. In fact, the proposed framework can realize the targets of MPS and TPS simultaneously by incorporating high-order information directly from rock images with the GANs scheme, while preserving low-order counterparts through conditioning. We conduct three reconstruction experiments, and the results demonstrate that rock type, rock porosity, and correlation length can be successfully conditioned to affect the reconstructed rock images. The randomly reconstructed samples with specified rock type, porosity and correlation length will contribute to the subsequent research on pore-scale multiphase flow and uncertainty quantification.
API-GNN: attribute preserving oriented interactive graph neural network
Authors: Zhou Yuchen , Shang Yanmin , Cao Yanan , Li Qian , Zhou Chuan , Xu Guandong 
Published: January 2022

AbstractAttributed graph embedding aims to learn node representation based on the graph topology and node attributes. The current mainstream GNN-based methods learn the representation of the target node by aggregating the attributes of its neighbor nodes. These methods still face two challenges: (1) In the neighborhood aggregation procedure, the attributes of each node would be propagated to its neighborhoods which may cause disturbance to the original attributes of the target node and cause over-smoothing in GNN iteration. (2) Because the representation of the target node is derived from the attributes and topology of its neighbors, the attributes and topological information of each neighbor have different effects on the representation of the target node. However, this different contribution has not been considered by the existing GNN-based methods. In this paper, we propose a novel GNN model named API-GNN (Attribute Preserving Oriented Interactive Graph Neural Network). API-GNN can not only reduce the disturbance of neighborhood aggregation to the original attribute of target node, but also explicitly model the different impacts of attribute and topology on node representation. We conduct experiments on six public real-world datasets to validate API-GNN on node classification and link prediction. Experimental results show that our model outperforms several strong baselines over various graph datasets on multiple graph analysis tasks.
Influence of solidification rates and heat treatment on the mechanical performance and joinability of the cast aluminium alloy AlSi10Mg
Authors: Neuser M. , Grydin O. , Frolov Y. , Schaper M. 
Published: January 2022

AbstractIn modern vehicle chassis, multi-material design is implemented to apply the appropriate material for each functionality. In spaceframe technology, both sheet metal and continuous cast are joined to castings at the nodal points of the chassis. Since resistance spot welding is not an option when different materials are joined, research is focusing on mechanical joining methods for multi-material designs. To reduce weight and achieve the required strength, hardenable cast aluminium alloys of the AlSi-system are widely used. Thus, 85–90% of aluminium castings in the automotive industry are comprised of the AlSi-system. Due to the limited weldability, mechanical joining is a suitable process. For this application, various optimisation strategies are required to produce a crack-free joint, as the brittle character of the AlSi alloy poses a challenge. Thus, adapted castings with appropriate ductility are needed. Hence, in this study, the age-hardenable cast aluminium alloy AlSi10Mg is investigated regarding the correlation of the different thicknesses, the microstructural characteristics as well as the resulting mechanical properties. A variation of the thicknesses leads to different solidification rates, which in turn affect the microstructure formation and are decisive for the mechanical properties of the casting as well as the joinability. For the investigation, plates with thicknesses from 2.0 to 4.0 mm, each differing by 0.5 mm, are produced via sand casting. Hence, the overall aim is to evaluate the joinability of AlSi10Mg and derive conclusions concerning the microstructure and mechanical properties.
Inclusion of groundwater and socio-economic factors for assessing comprehensive drought vulnerability over Narmada River Basin, India: A geospatial approach
Authors: Swain Sabyasachi , Mishra Surendra Kumar , Pandey Ashish , Kalura Praveen 
Published: January 2022

AbstractDrought is amongst the most precarious natural hazards associated with severe repercussions. The characterization of droughts is usually carried out by the sector-specific (meteorological/agricultural/hydrological) indices that are mostly based on hydroclimatic variables. Groundwater is the major source of water supply during drought periods, and the socio-economic factors control the aftermaths of droughts; however, they are often ignored by the sector-specific indices, thereby failing to capture the overall impacts of droughts. This study aims to circumvent this issue by incorporating hydroclimatic, socio-economic and physiographic information to assess the overall drought vulnerability over Narmada River Basin, India, which is an agriculture-dominated basin highly dependent on groundwater resources. A Comprehensive Drought Vulnerability Indicator (CDVI) is proposed that assimilates the information on meteorological fluctuations, depth to groundwater level, slope, distance from river reach, population density, land use/land cover, soil type, and elevation through a geospatial approach. The CDVI showed a remarkable geospatial variation over the basin, with a majority (66.4%) of the area under highly to extremely vulnerable conditions. Out of 35 constituent districts of the basin, 9, 22, and 4 districts exhibited moderate, high, and extreme vulnerability to droughts, respectively. These results urge an immediate attention towards reducing drought vulnerability and enhancing resilience towards drought occurrences. The proposed multi-dimensional approach for drought vulnerability mapping would certainly help policy-makers to proactively plan and manage water resources over the basin, especially to ameliorate the pernicious impacts of droughts.
Evaluation of guidance provided by international standards on metrics and timelines for run-life estimation of oil and gas equipment
Authors: Selvik Jon T. , Alhanati Francisco J. S. , Signoret Jean-Pierre 
Published: January 2022

AbstractRun-life is a concept used in the oil and gas industry to express time to failure for running equipment. When estimating this as part of reliability engineering activities, different metrics and time periods are considered. One metric is the traditional ‘mean time to failure’ (MTTF), but alternatives such as ‘average run-time’ or ‘average run-life’ can also be considered. For calculating these metrics, different time periods can be used. For example, when estimating the MTTF of well completion equipment, operating times or running times are normally used. However, the periods can also include idle time, where the item is technically available, but associated parts of the production facility might not be. For consistency across the industry, on how to interpret the metrics and what to include in calculating them when performing estimations, ISO 14224 (2016) and IEC 60050-192 (2015) in tandem provide guidance to ensure quality in reliability data collection and analysis. While MTTF is defined and a theoretical basis is given, guidance on when to use the different timelines for the estimation is sparse. Neither ‘run-time’ nor ‘run-life’ is explicitly defined in these standards. They provide no guidance on how to interpret and use the metrics ‘average run-time’ and ‘average run-life’, despite these sometimes replacing the MTTF in reliability analyses. In this article, we discuss the variation in metrics and associated timeline definitions. A main purpose is to identify improvement potentials in the international standards and suggest how to achieve appropriate guidance for consistent interpretation and use of time-to-failure metrics in the oil and gas industry. An additional purpose is to clarify whether all these metrics are really needed. There is particularly confusion around ‘run-time’, which some interpret as a reliability metric and some as an item’s cumulative running time. One suggestion is that the standards focus more on ‘running time’, by adding a formal definition, and clarify how it compares with operating time and run-time, and when to use it. We also suggest introducing ‘running time to failure’ and ‘operating time to failure’, which would be consistent with existing terminology, while clarifying the timeline being referred to. We use examples from well drilling and completion systems, to show the reliability implications for modeling and calculations.
Validation of the Swedish Watson Dysphagia Scale for adult patients with eosinophilic esophagitis
Authors: Albinsson Sofie , Tuomi Lisa , Wennerås Christine , Larsson Helen 
Published: January 2022

SUMMARY
Background: The Swedish Watson Dysphagia Scale (S-WDS) has been used to assess dysphagia in patients with eosinophilic esophagitis (EoE) but has not been validated for this patient group. The aim of this study was to validate the S-WDS for adult patients with EoE. Methods: Ninety-seven Swedish adult patients with EoE and 97 controls without dysphagia filled out the S-WDS, the Swedish Eosinophilic Esophagitis Activity Index (S-EEsAI) and a set of supplementary questions. The reliability of the S-WDS was evaluated using Cronbach’s alpha, Pearson correlation of items and total score, and test–retest analysis (n = 29). Validity was investigated using Spearman correlations of the S-WDS items, S-EEsAI domains and a self-assessment score, and by investigating floor and ceiling effects. Results: The Cronbach’s alpha of the S-WDS was 0.77 and all items demonstrated moderate to strong correlation to the S-WDS score (r = 0.40–0.81) indicative of sufficient reliability of the instrument. In addition, the test–retest results reflected excellent reliability with an intraclass correlation coefficient of 0.85 for the S-WDS score. Adequate validity of the instrument was demonstrated, the S-WDS score correlated moderately with the self-assessment score and with 4/6 S-EEsAI domains, and strongly with the remaining two domains. Floor effects were more common for liquids and soft-textured foods and ceiling effects increased with increasing food consistency. The S-WDS scores of the patient group were significantly different from those of the nondysphagia control group (P &lt; 0.001). Conclusion: The S-WDS instrument is an appropriate and valid instrument for assessment of dysphagia in patients with EoE.
Hiatal hernias associated with acid reflux: size larger than 2 cm matters
Authors: Shahsavari Dariush , Smith Michael S , Malik Zubair , Parkman Henry P 
Published: January 2022

Abstract
Hiatal hernia (HH) is associated with gastroesophageal reflux disease (GERD); the effect of HH size on GERD is not well defined. To evaluate the relationship between HH size as measured by high-resolution esophageal manometry (HREM) and reflux parameters on esophageal pH-impedance testing (multichannel intraluminal impedance-pH [MII-pH]) to define HH sizes associated with GERD. HREM and MII-pH studies were reviewed. The relationship of HH size to other parameters was analyzed with multivariable logistic regression. Correlation coefficients were determined using Spearman and Pearson’s tests. A total of 897 patients underwent both HREM and MII-pH. There were 529 (58.9%) patients with HH size &lt;1 cm, 203 (22.6%) with HH 1.0–1.9 cm, and 165 (18.4%) with HH ≥2 cm. Larger HH size was associated with lower esophageal sphincter (LES) basal and residual pressures (r = −0.43 and r = −0.48, p &lt; 0.01), higher acid exposure time (AET) (r = 0.17, p &lt; 0.01), number of acidic refluxes (r = 0.16, p &lt; 0.05), and number of reflux episodes detected by impedance (total r = 0.22, p &lt; 0.01). HH ≥ 2 cm compared with smaller size HH was associated with higher proximal AET%, acidic refluxes, and reflux episodes detected by impedance (p &lt; 0.05). Increasing HH size was associated with older age, higher AET, and number of reflux episodes. HH ≥2 cm was associated with multiple worsened GERD parameters. Low LES pressure was weakly associated with an increase in the number of reflux episodes. Larger HHs, particularly &gt;2 cm, are associated with more severe GERD parameters.
A Natural History of Patients Treated Operatively and Nonoperatively for Spinal Metastases Over 2 Years Following Treatment
Authors: Xiong Grace X. , Fisher Miles W.A. , Schwab Joseph H. , Simpson Andrew K. , Nguyen Lananh , Tobert Daniel G. , Balboni Tracy A. , Shin John H. , Ferrone Marco L. , Schoenfeld Andrew J. 
Published: January 2022

Study Design.
Prospective observational study.

Objective.
We present the natural history, including survival and function, among participants in the prospective observational study of spinal metastases treatment investigation.

Summary of Background Data.
Surgical treatment has been touted as a means to preserve functional independence, quality of life, and survival. Nearly all prior investigations have been limited by retrospective design and relatively short-periods of post-treatment surveillance.

Methods.
This natural history study was conducted using the records of patients who were enrolled in the prospective observational study of spinal metastases treatment study (2017–2019). Eligible participants were 18 or older and presenting for treatment of spinal metastatic disease. Patients were followed at predetermined intervals (1, 3, 6, 12, and 24-mo) following treatment. We conducted cox proportional hazard regression analysis adjusting for confounders including age, biologic sex, number of comorbidities, type of metastatic lesion, neurologic symptoms at presentation, number of metastases involving the vertebral body, vertebral body collapse, New England Spinal Metastasis Score (NESMS) at presentation, and treatment strategy.

Results.
We included 202 patients. Twenty-three percent of the population had died by 3 months following treatment initiation, 51% by 1 year, and 70% at 2 years. There was no significant difference in survival between patients treated operatively and nonoperatively (P = 0.16). No significant difference in HRQL between groups was appreciated beyond 3 months following treatment initiation. NESMS at presentation (scores of 0 [HR 5.61; 95% CI 2.83, 11.13] and 1 [HR 3.00; 95% CI 1.60, 5.63]) was significantly associated with mortality.

Conclusion.
We found that patients treated operatively and nonoperatively for spinal metastases benefitted from treatment in terms of HRQL. Two-year mortality for the cohort as a whole was 70%. When prognosticating survival, the NESMS appears to be an effective utility, particularly among patients with scores of 0 or 1.

Level of Evidence: 2