bluuebunny/crossref_metadata_2025_split huggingface dataset:
EMG-driven bilateral therapy for hand rehabilitation: Evaluation of the influence of an EMG-based visual biofeedback on the users’ performance
Authors: Cisnal A. , Gordaliza P. , Turiel J. P. , Fraile J. C. , Sierra D. 
Published: May 2022

Abstract
Background: The development of rehabilitation robotic systems has experienced significant growth in recent years. Electromyography (EMG) is commonly used to drive this kind of robots. Although there are some studies that have assessed the effectiveness of EMG biofeedback in neurorehabilitation, none of them has applied this technique in combination with robotic platforms.Objectives: Our goal was to evaluate the influence of EMG biofeedback on the user performance, when individuals were asked to perform different hand gestures (open, rest and close) using an EMG-driven robotic hand exoskeleton rehabilitation platform. Methods: A total of 18 healthy subjects were enrolled in the study. The subjects were asked to perform 1-minute randomly generated sequences of hand gestures in four different conditions resulting from the combination of using or not (1) EMG-based visual biofeedback (2) kinesthetic feedback from the exoskeleton movement Results: The subject performance was statistical significantly better when the EMG-based visual feedback was present, while kinesthetic feedback did not improve their performance. The performance when both sources of feedback were present did not resulted in any enhancement, indicating that the kinesthetic feedback overrides the effect of the electromyographic one.Conclusion: The EMG-based visual feedback enables subjects to increase their control over the movement of the robotic platform by assessing their muscle activation in real-time. This type of feedback could benefit the patients in learning faster how to co-activate the motions of the rehabilitation robot, which may increase their motivation.
Implementation of a medicine management plan (MMP) to reduce medication-related harm (MRH) in older people post-hospital discharge: a randomised controlled trial
Authors: Ali Khalid , Mensah Ekow , McDermott Eugene Ace , Kirkham Frances A , Stevenson Jennifer , Hamer Victoria , Parekh Nikesh , Schiff Rebekah , Cammen Tischa van Der , Nyangoma Stephen , Fowler-Davis Sally , Davies Graham , Gage Heather , Rajkumar Chakravarthi 
Published: May 2022

Abstract
BackgroundMedication-related harm (MRH) is an escalating global challenge especially among older adults. The period following hospital discharge carries high-risk for MRH due to medication discrepancies, limited patient/carer education and support, and poor communication between hospital and community professionals. Discharge Medical Service (DMS), a newly introduced NHS scheme, aims to reduce post-discharge MRH through an electronic communication between hospital and community pharmacists. Our study team has previously developed a risk-prediction tool (RPT) for MRH in the 8-weeks period post discharge from a UK hospital cohort of 1280 patients. MethodUsing a randomized control trial design, 682 older adults ≥ 65years due to be discharged from hospital will be recruited from 4 sites. Participants will be randomized to an intervention arm (individualised medicine management plan (MMP) plus DMS) or a control arm (DMS only) using a 1:1 ratio stratification. Baseline data will include patients’ clinical and social demographics, and admission and discharge medications. At 8-weeks post-discharge, a telephone interview and review of GP records by the study pharmacist will verify MRH in both arms. An economic and process evaluation will assess the cost and acceptability of the study methods.Data AnalysisUnivariate analysis will be done for baseline variables comparing the intervention and control arms. A multivariate logistic regression will be done incorporating these variables. Economic evaluation will compare the cost-of-service use among the study arms and modelled to provide national estimates. Qualitative data from focus-group interviews will explore practitioners’ understanding, and acceptance of the MMP, DMS and the RPT. ConclusionThis study will inform the use of an objective, validated RPT for MRH among older adults after hospital discharge, and provide a clinical, economic, and service evaluation of a specific medicines management plan alongside the DMS in the National Health Service (UK).
Analysis of 12 Trace Elements in the Sera and Placental Tissues of Pregnant Women with Gestational Diabetes Mellitus in Beijing
Authors: Liu Sana , Fang Haiqing , Wang Qihe , Zhang Mingyuan , Qu Pengfeng , Deng Taotao , Li Huzhong , liang Dong , Liu Aidong 
Published: May 2022

Abstract
The present study aimed to detect and analyze the concentrations of 12 trace elements in the sera and placental tissues of pregnant women with gestational diabetes mellitus (GDM) in Beijing, China using inductively coupled plasma mass spectrometry. Thirty pregnant women that participated in this study, and 20 matched normal controls were recruited in the study; the concentrations of trace elements were compared between these groups. The trace elements iron (Fe), copper (Cu), zinc (Zn), selenium (Se), chromium (Cr), manganese (Mn), nickel (Ni), strontium (Sr), lead (Pb), aluminum (Al), arsenic (As), and palladium (Pd) were detected in the sera and placental tissues of the pregnant women. Using a double antibody sandwich ELISA, the activity of glutathione peroxidases (GPXs), including GPX1-4, were assessed in the placental tissues. Compared with healthy pregnant women, the concentrations of Fe, Cu, Se, and Cr in the sera of pregnant women with GDM were significantly increased (P ˂ 0.05), whereas no significant differences in Al, Mn, Ni, As, Sr, Pd, and Pb sera concentrations were detected between these groups(P > 0.05); And Zn concentrations did not quite achieve acceptable levels of statistical significance (P = 0.047). Also in comparison to healthy pregnant women, Fe concentrations in the placental tissues of pregnant women with GDM were significantly increased (P ˂ 0.05), whereas Zn, Mn, Al, and As concentrations were significantly decreased (P ˂ 0.05); however, the concentrations of Cr, Ni, Se, Sr, Pd, Pb, and Cu in placental tissues did not differ between the groups. In addition, GPX1-4 activity did not differ between the GDM and healthy groups. The differences in trace element concentrations detected in pregnant patients with GDM and healthy pregnant patients suggest that some elements, such as Fe, Cu, Zn, and Se may play important roles in the disease and could be considered potential biomarkers.
A nationwide population-based cohort study of the association betweem visual loss and risks of suicide and mental illness in Taiwan
Authors: Sung Chieh , Chung Chi-Hsiang , Lin Fu-Huang , Chien Wu-Chien , Sun Chien-An , Tsao Chang-Huei , Weng Chih-Erh 
Published: May 2022

Abstract
Background: The psychosocial and health consequences of ocular conditions that cause visual impairment (VI) are extensive and include impaired daily activities, social isolation, cognitive impairment, impaired functional status and functional decline, increased reliance on others, increased risk of motor vehicle accidents, falls and fractures, poor self-rated health, and depression. We aimed to determine whether VI increases the risk and progression of mental illness, suicide, and mortality over time.Methods: To conduct a large, countrywide, population-based, nested, cohort study, we used the data recorded from 2000 to 2015 in the Taiwan’s National Health Insurance Research Database (NHIRD), which included all diagnoses of patients with VI. Baseline features, comorbidities, and prognostic variables were evaluated in 1:4-matched study and comparison cohorts using Cox proportional hazards regression to study the association between VI and a poor prognosis(mental illness, suicide, and mortality). The study outcome was the cumulative incidence of VI in patients with suicide and mental health risks during a 15-year follow-up period.Results: Among the 1,949,101 patients enlisted in the NHIRD, 359 had been diagnosed with VI. Cox regression analysis identified the risk factors for poor prognosis, and the crude hazard ratio was 3.004 (95% confidence interval 2.135–4.121, p<0.001). Participants with VI had an increased risk of poor prognosis, even after excluding individuals with a diagnosis of poor prognosis within the first year and the initial 5 years. VI was associated with suicide and mental health risks.Conclusions: VI increases the likelihood of a poor prognosis. Early detection through comprehensive examinations based on increased awareness in the clinical context may help maintain visual function and avoid additional complications.
Increased prevalence of human papillomavirus in fresh tissue from penile cancers compared to non-malignant penile samples: A case-control study.
Authors: Kristiansen Sinja , Bjartling Carina , Torbrand Christian , Grelaud Diane , Lindström Martin , Svensson Åke , Forslund Ola 
Published: May 2022

Abstract
Background: HPV has been detected in approximately 50% of invasive penile cancers but with a large span between 24% and 89%, most likely due to different types of tumors and various methods for HPV analysis. Most studies of HPV in penile cancer have been performed using paraffin-embedded tissue, argued to be at risk for contaminated HPV analysis. Viral activity of HPV, by the use of HPV mRNA expression is well studied in cervical cancer, but seldom studied in penile cancer.The aim was to determine prevalence of HPV types in fresh tissue of penile cancers compared to non-malignant age-matched penile controls. Additional aims were to analyze the viral expression and copy numbers of HPV16-positive tumors and 10 mm adjacent to the tumor.Methods: Fresh tissue from penile cancer cases was biopsied inside the tumor and 10 mm outside the tumor. Controls were males circumcised for non-malignant reasons, biopsied at surgery.PCR and Luminex assays were used for identification of HPV types. HPV16-positive samples were investigated for copy numbers and expression of HPV16-mRNA. Results: Among tumors (n=135) and age-matched controls (n=105), HPV was detected in 38.5% (52/135) and 11.4% (12/105), respectively (p <0.001), adjusted odds ratio 12.8 (95% confidence interval 4.9-33.6). High-risk HPV types were found in 34.3% (48/135) of tumors and 4.8% (5/105) of controls (p<0.001). Among tumors and controls, HPV16 was present in 27.4% (37/135) and 1% (1/105), respectively (p<0.001). Among HPV16-positive penile cancers, mean HPV16 viral copy/cell was 74.4 (range 0.00003 – 725.4) in the tumor and 1.6 (range 0.001 – 14.4) 10 mm adjacent from the tumor. HPV16-mRNA analysis of the tumors and 10 mm adjacent from the tumors demonstrated viral activity in 86.5% (32/37) and 21.7% (5/23), respectively. Conclusions: The prevalence of HPV was significantly higher in penile cancer (38.5%) than among age-matched non-malignant penile samples (11.4%). HPV16 predominates (27.4%) in penile tumors. HPV16 expression was more common in penile cancer than in adjacent healthy tissue, strongly suggesting an etiological role for HPV16 in the development of penile cancer.
Sequence and Haplotype Analyses of Ligula intestinalis in Acanthobrama Marmid (Cyprinidae) in Turkey
Authors: Kesik Harun Kaya , Celik Figen , Turk Cebrahil , Kilinc Seyma Gunyakti , Simsek Sami , Gul Abdurrahman 
Published: May 2022

Abstract
Ligulosis caused by Ligula intestinalis adversely affects the fisheries carried out in the lakes and ponds of in Turkey. This parasite causes economic losses in the fish industry. In this study, it was aimed to reveal the molecular characterization of L. intestinalis isolates obtained from woodfish (Acanthobrama marmid) in Keban Dam Lake in Elazig province of Turkey by using mt-CO1 gene sequences and to determine the genetic differences and haplotypes between the isolates. In the examination made in terms of L. intestinalis, the intestine of the fish was opened with the help of fine-tipped scissors, the contents were allowed to come out, and the parasites were taken into a petri dish containing physiological water. Then, L. intestinalis plerocercoids were taken into 15 ml falcon tubes containing 70% ethanol and stored at -20ºC until further analysis. From each isolate, total gDNA was extracted from the plerocercoids. A partial (480 bp) mt-CO1 gene was amplified by PCR and sequenced unidirectionally. The final size of the trimmed sequences was 392 bp for 43 sequences. Sequence and haplotype analyses were performed, followed by phylogenetic analyses. All isolates were confirmed as L. intestinalis by BLAST analysis. In addition, 87 nucleotide mutation positions were determined among 43 CO1 gene sequences. As a result of the haplotype network performed for the mt-CO1 gene region of L. intestinalis isolates; arranged in a star-like configuration with the main haplotype (Hap05), separated from other haplotypes by 1–6 mutation steps, and 29 haplotypes were identified, covering 13.9% (6/43) of the total isolates. Also, 75 variable (polymorphic) sites were determined, 52 of which were parsimony informative sites.
Molecular characterization of novel endornavirus isolated from Ophiostoma bicolor associated with bark beetles
Authors: Zhu Yuyao , Lu Anna , Wang Zheng , Lu Quan , Chengming Yu , Liu Huixiang 
Published: May 2022

Abstract
Ophiostoma bicolor is a pathogen fungus associated with bark beetles that can cause serious damage to host plants. In this study, a novel fungal virus “Ophiostoma bicolor endornavirus 1” (ObEV1) was obtained from O. bicolor , and its complete genome sequence was determined. ObEV1 has a singlestranded positive-sense (+ss) RNA genome of 10119 nucleotides, Sequence annotation and comparison showed that the viral genome has a single large open reading frame (ORF) encoding a polyprotein of 362.48 kDa. The polyprotein contains seven conserved domains: RNA dependent RNA polymerase (RdRp), Viral RNA Helicase 1 (VHel1), Viral-methyltransferase (VMet), DEAD-like helicases (DEXDc), gliding-GltJ (G1), large tegument protein UL36 (PHA) and YlqF-related-GTPase (Y). Sequence comparisons and phylogenetic analysis showed that ObEV1 is a novel mycovirus belonging to the Betaendornavirus of “ Endornaviridae ” family. This is the first report of mycovirus in O. bicolor of Ophiostomatoid fungi.
A Practical Dental Image Enhancement Network for Early Diagnosis of Oral Dental Disease
Authors: khan rizwan , Long Zhong , Mehmood Atif , Qaisar Zahid 
Published: May 2022

Abstract
Intelligent robotics and expert system applications in dentistry suffer from identification and detection problems due to the non-uniform brightness and low contrast in the captured images. Moreover, during the diagnostic process, exposure of sensitive facial parts to ionized radiations (e.g., X-Rays) has several disadvantages and provides a limited angle for the view of vision. Capturing high-quality medical images with advanced digital devices is challenging, and processing on these images distorts the contrast and visual quality. It curtails the performance of potential intelligent and expert systems and disincentives the early diagnosis of oral and dental diseases. The traditional enhancement methods are designed for specific conditions, and network-based methods rely on large-scale datasets with limited adaptability towards varying conditions. This paper proposed a novel and adaptive dental image enhancement strategy based on a small dataset, and proposed a paired branch Denticle-Edification network (Ded-Net). The input dental images are decomposed into reflection and illumination in a multilayer Denticle network (De-Net). The subsequent enhancement operations are performed to remove the hidden degradation of reflection and illumination. The adaptive illumination consistency is maintained through the Edification network (Ed-Net). The network is regularized following the decomposition congruity of the input data and provides user-specific freedom of adaptability towards desired contrast levels. The experimental results demonstrate that the proposed method improves visibility and contrast and preserves the edges and boundaries of the low contrast input images. It proves that the proposed method is suitable for intelligent and expert system applications for future dental imaging.
A robotic polishing parameter optimization method considering time-varying wear
Authors: Zheng Qianjian , Xiao Juliang , Wang Chao , Liu Haitao , Huang Tian 
Published: May 2022

Abstract
In the automatic polishing process, the wear of polishing tools and the change of polishing parameters will affect the Preston coefficient, which makes it difficult to establish an accurate material removal model to achieve stable and excellent polishing quality. In this paper, a robotic polishing parameter optimization method considering time-varying wear is proposed to address these issues. First, combining the rich information in the theoretical modeling method with the data-driven regression method, a material removal regression model incorporating prior knowledge is proposed, which greatly reduces the large amount of experimental data required by the original regression model. The proposed model is able to track the wear variation of the sandpaper as well as the effect of polishing parameters. Then, based on the proposed prediction model, the polishing parameters are optimized using the genetic algorithm to achieve better machining quality and less energy consumption. Finally, the experimental verification is carried out on the hybrid robot polishing test bench. The results show that the proposed material removal regression model incorporating prior knowledge has higher prediction accuracy and less required experimental data than existing models. The proposed robot polishing parameter optimization method can effectively compensate for tool wear and ensure consistent material removal during polishing while reducing energy consumption.
Construction of new quantum color codes
Authors: Naghipour Avaz , Nguyen Duc Manh 
Published: May 2022

Abstract
This paper presents a hyperbolic geometry approach to the construction of new quantum color codes. The families of quantum color codes are constructed based on the identification of compact surfaces by hyperbolic tessellations. Codes of these families have 4 and 6 minimum distances and their encoding rate are near to 1. We also provide some quantum color codes with minimum distance of at least eight and a comparison table of quantum codes.
Does External Debt Promote Human Longevity in Developing Countries?
Authors: Aladejare Samson Adeniyi 
Published: May 2022

Abstract
This study assessed the impact of external debt on longevity in developing countries, particularly in West Africa, from 1981 to 2020. Longevity was proxied by life expectancy at birth, while the external debt effect was evaluated from the perspective of sustainability, liquidity, and solvency. Furthermore, outcomes from macroeconomic volatility were controlled through inflation and exchange rate variability. Methodological robustness was ensured by adopting panel unit root, cointegration, and estimation procedures incorporating panel dataset cross-sectional dependency and heterogeneity in their estimation process. Robust inferences for the study were derived by comparing estimated outcomes from the cross-sectional augmented autoregressive distributed lag, dynamic common correlated effects, and the Driscoll-Kraay method. Empirically, the study showed that unsustainable, illiquid, and insolvent external debt and macroeconomic volatility shorten longevity in West African countries. Hence, longevity will decline when weak external debt management promotes poverty in developing countries.JEL Classification: H53, H63, I31.
Accuracy of intraoral scanners according to subgingival depth of abutment for fixed prosthesis
Authors: Son Young-Tak , Son KeunBaDa , Lee Kyu-Bok 
Published: May 2022

Abstract
Purpose: This study aimed to compare the accuracy of intraoral scanners (IOSs) according to the subgingival finish line depth of tooth preparation for fixed prostheses.Methods: The maxillary right first molar tooth preparation model was fabricated using ceramic material. A computer-aided design (CAD) reference model (CRM) of the abutment was obtained using a contact scanner. The subgingival finish line was located according to the depth at 0-mm, 0.25-mm, 0.5-mm, 0.75-mm, and 1-mm. CAD test models (CTMs) were obtained using 2 IOSs. CRM and CTM were superimposed and analyzed. The one-way analysis of variance (ANOVA) was used to compare the accuracy according to the subgingival finish line depth. The paired t test was used to compare the accuracy of IOSs with and without gingival retraction (α=.05).Results: When the gingival displacement cord was not used, a significant difference was observed in accuracy according to the subgingival finish line depth in the marginal region in both IOSs (P < 0.001). When the subgingival finish line was positioned at a depth of ≥ 0.5-mm, the accuracy of both IOSs exceeded 100 µm in the marginal region. Furthermore, when the gingival displacement cord was used, the accuracy of both IOSs did not exceed 100 µm regardless of the subgingival finish line depth.Conclusions: With the increase of subgingival finish line depth, the inaccuracy increased, but the use of the gingival displacement cord improved the scan accuracy. Thus, the use of a gingival displacement cord is recommended to improve scan accuracy when using a subgingival finish line.
Systematic Literature Review: Software Engineering Frameworks
Authors: Prates Luis , Pereira Rúben 
Published: May 2022

Abstract
The definition of a Framework from the English dictionary is a basic structure, plan, or system, as of concepts, values, customs, or rules. Another definition is a skeletal structure designed to support or enclose something. In Software Engineering, a framework is a common term, and the field has it grew also proliferated an uncountable number of frameworks. Considering the increasing number of frameworks within Software Engineering, researchers think it valuable to precisely establish the definition of framework within the context of Software Engineering, which types of frameworks exist and the expected benefits of having them as a basis for creating future Software Engineering frameworks. Therefore, in this paper, researchers applied a Systematic Literature Review to the framework developed within the academia, and the findings are summarized.
Acrylamide formation and characterizations of flaky rolls substituted with Taiwan black rice (Oryza sativa L.)
Authors: Lu Wen-Chien , Chan Yung-Jia , Le Dung Huynh Thi , Li Po-Hsien 
Published: May 2022

Abstract
This study aims to investigate the physicochemical composition, textural parameters, and chemical constituent of flaky rolls incorporated with different proportions of black rice flour. According to farinographic characteristics, the addition of black rice could reduce the stability and increase the dough development time and water absorption (%). According to extensographic properties, the addition of black rice resulted in significantly different maximum resistance to extension (BU) and extensibility (cm) versus the control. With the addition of black rice in flaky rolls, the crude protein, total dietary fiber (TDF), soluble dietary fiber (SDF), and insoluble dietary fiber (IDF) were significantly improved. Glucose released was much lower with 10% and 20% black rice than the control and 5% black rice because of the higher black rice inclusion. TDF, SDF, and IDF also increased. With increasing black rice incorporation, total anthocyanin content was also increased, as was total phenolic content, 2,2-diphenyl-1-picrylhydrazyl, and oxygen radical absorption capacity. The content of asparagine, acrylamide, hydroxymethylfurfural, furfural, methylglyoxal, and glyoxal in flaky rolls was also increased. The proper content of black rice flour (5%) could significantly enhance the stability of the dough properties; control the final volume, texture, and appearance; and retain good protein and fiber composition, antioxidant capacity, and overall acceptance of the flaky roll.