bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empfindsame Urbanität
Authors: Kühlmann Wilhelm 
Published: August 2022

Abstract
Sophie von La Roche’s ‘Letters on Mannheim’ (1791) are examined in the context of their origin as well as in the wide and complex field of epistolary forms, purposes and themes. The study analyses La Roche’s autobiographical, journalistic and cultural-pedagogical claim in these letters as well as its hybrid character as a work of literature, which oscillates between fictionality and factuality. Even though this document of the late Enlightenment deals with important personalities, landmarks and institutions of Mannheim (such as the theatre), everyday questions of behavioural culture and intellectual orientation are repeatedly addressed. Thus, the multipurpose nature of public letter writing in late eighteenth century will be demonstrated with a characteristic example.
Verbriefte Ehe
Authors: Harst Joachim 
Published: August 2022

Abstract
This article deals with the adaptation of the correspondence of Abelard and Heloisa in the form of the heroic epistle which became popular in the 18th century. It pursues the thesis that in going back to Ovid, the heroic epistle and its discourse of love stands in a contradictory relationship to the Christian correspondence of the medieval lovers. Therefore, the early modern adaptations ignore the community-building function of the love story and have to rewrite it in terms of unfulfilled love.
Thyroid Cancer Incidence, Clinical Presentation, and Survival Among Native Hawaiian and Other Pacific Islanders
Authors: Moon Peter K. , Chakoma Tatenda , Ma Yifei , Megwalu Uchechukwu C. 
Published: August 2022

AbstractObjectiveTo assess the incidence, clinical presentation, and survival in Native Hawaiian and other Pacific Islander (NHPI) patients with well‐differentiated thyroid cancer.Study DesignThis population‐based incidence analysis and retrospective cohort study utilized data from the Surveillance, Epidemiology, and End Results database.SettingIncidence analysis included patients diagnosed between 1990 and 2014, while the cohort to study clinical presentation and survival comprised patients diagnosed between 2004 and 2015.MethodsIncidence rates and trends were compared among NHPI, Asian, and non‐Hispanic White (NHW) populations. Clinical presentation was assessed via multivariable logistic regression. Survival was assessed per Cox regression.ResultsRecent incidence trends (2009‐2014) show that the rate of increase remained consistent among NHPI patients (annual percentage change, 3.67%; 95% CI, 2.66%‐4.69%), while it slowed in the NHW population and plateaued among Asians as compared with previous years. NHPI patients were more likely to present with distant metastasis than NHW patients (odds ratio, 3.37; 95% CI, 1.97‐5.36) and Asian patients (odds ratio, 1.82; 95% CI, 1.05‐2.97). NHPI race was also associated with advanced T stage and nodal metastasis as compared with the NHW race. Survival outcomes were similar among NHPI, NHW, and Asian patients.ConclusionWell‐differentiated thyroid cancer incidence has increased at a higher rate for the NHPI population as opposed to the NHW and Asian populations in recent years. NHPI patients are more likely to present with advanced disease when compared with NHW and Asian patients. These results highlight the importance of disaggregating the often‐combined Asian/Pacific Islander group in epidemiologic studies.
Tissue plasminogen activator in left ventricular assist device-related intravascular hemolysis after failed augmented anticoagulation
Authors: Kenneth Sims Robert , Srour Nina , El Nihum Lamees I , Hannawi Bashar , Araujo-Gutierrez Raquel , Cruz-Solbes Ana S , Trachtenberg Barry H , Hussain Imad , Kim Ju H , Kassi Mahwash , Graviss Edward A , Nguyen Duc T , Estep Jerry , Bhimaraj Arvind , Guha Ashrith 
Published: August 2022

Objectives: We sought to examine the efficacy and safety of adding fibrinogen-guided low-dose multi-day Alteplase™ tissue plasminogen activator (tPA) in the management of intravascular hemolysis (IVH) in patients with the HeartMate II (HM-II) continuous flow (CF) left ventricular assist device (LVAD) who failed to achieve IVH resolution with conventional augmented anticoagulation (AAC). Background: IVH in patients with LVAD is often treated with AAC, failing which pump exchange is considered. We hypothesized that a trial of low-dose tPA after failed AAC therapy could resolve IVH and prevent pump exchange in some patients. Methods: We performed a retrospective study of 31 HM-II CF LVAD patients admitted to our center from January 2015 to January 2020 for IVH management who received tPA following failed AAC. Primary 6-month outcomes included successful IVH resolution, unsuccessful IVH resolution requiring pump exchange, gastrointestinal bleeding, ischemic and hemorrhagic cerebrovascular accident (CVA), and death. Results: Thirty-one patients with IVH were treated with tPA following failed AAC. Successful resolution of IVH occurred in 22/31 (71%) patients. Pump exchange occurred in 9/31 (29%) patients. Gastrointestinal bleeding occurred in 7/31 (22.6%) patients. Ischemic CVA occurred in 6/31 (19.4%) patients. Conclusions: Management of IVH with administration of low-dose tPA after failed AAC is feasible and may prevent pump exchange in some patients.
Do Adult Attachment Style or Personality Mediate the Relationship Between Childhood Maltreatment and Late-Life Depression in Poor Communities?
Authors: Gomes Jardim Gabriel Behr , Gomes Irenio , Mehdi Gholam , Ranjbar Setareh , Engroff Paula , Santos Milena Antunes , Neto Alfredo Cataldo , von Gunten Armin 
Published: August 2022

Objective Childhood maltreatment is associated with late-life depression. Preliminary evidence indicates that personality characteristics, in particular neuroticism and extroversion, and an anxious attachment style mediate this association. The objective is to evaluate 3 models, in which personality and attachment are considered mediators between childhood maltreatment and late-life depression in a socioeconomically disadvantaged Brazilian population. Methods This study included participants (n = 260) from socioeconomically disadvantaged neighborhoods of Porto Alegre, Brazil, who completed measures of childhood maltreatment (Childhood Trauma Questionnaire – CTQ), personality characteristics (NEO-Five Factor Inventory), attachment styles (Relationship Scales Questionnaire), and geriatric depression (Mini-International Neuropsychiatric Interview-Plus). General multiple and sequential mediation analyses were used to test for possible associations. Results Attachment anxiety but not attachment avoidance is a mediator between childhood maltreatment and geriatric depression. Neuroticism is a full mediator. At that, attachment anxiety was found to be a predictor of neuroticism. Finally, sequential mediation analysis shows a path from childhood maltreatment to geriatric depression through attachment anxiety and neuroticism. Conclusions The results suggest a pathway from childhood maltreatment to anxious attachment, which in turn predicts higher neuroticism that itself may favor late-life depression. This hypothesis could have implications for older adults living in low socioeconomic settings in that treating the high-risk group of maltreated children may help prevent late-life depression.
Social values and sustainable development: community experiences
Authors: Leal Filho Walter , Levesque Vanessa , Sivapalan Subarna , Salvia Amanda Lange , Fritzen Barbara , Deckert Ronald , Kozlova Valerija , LeVasseur Todd Jared , Emblen-Perry Kay , Azeiteiro Ulisses M. , Paço Arminda , Borsari Bruno , Shiel Chris 
Published: August 2022

Abstract
Background
This paper presents a review of the literature and trends related to social values and sustainable development and describes a set of case studies from a variety of community-based projects which illustrate the advantages that social values bring about as part of efforts to promote sustainability. Three approaches were used to develop this study: a bibliometric analysis of the topic “social values and sustainable development”, an analysis of case studies that concretely present community projects addressing social values and sustainability, and the development of a framework linking up bibliometric clusters and the cases studies.

Results
While the bibliometric analysis revealed clusters where social values are strongly connected with sustainable development, the case studies indicated the lack of a common terminology and understanding of the relation between social values, sustainable development, and community-based projects.

Conclusions
The study concludes by suggesting a set of measures that could be deployed to better take social values into account when planning policies or making decisions related to community projects.
Concentration, sources and health effects of silica in ambient respirable dust of Jharia Coalfields Region, India
Authors: Singh Shailendra K. , Singh Ranjeet K. , Singh Krishnakant K. , Singh Ranjeet K. , Singh Siddharth 
Published: August 2022

Abstract
Background
The concentration of silica in occupational conditions is well defined and estimated around the world. Many countries in the world have developed air standards for occupational conditions based on the percent silica in ambient air. This is due to the pulmonary effect caused by silica yielding diseases like silicosis and pneumoconiosis. In India, occupational exposure to silica dust is regulated by Directorate General of Mine Safety (Tech.) (S&T) Circular No. 1 of 2004 Under Reg. 123 of Coal Mines Regulations, 1957 for any metal/non-metal mining operations estimated gravimetrically. As no silica standards are prescribed in India for non-occupational conditions, venturing into such analysis was well envisaged and perceived.

Methodology
Air sampling was done at identified locations through high-volume samplers for 24 h, twice a week in pre-monsoon season (March to June) and the Whatman filter paper was sonicated at sufficient speed to isolate dust particles for energy dispersive X-ray.

Results
The percentage of silica in “PM10” was found lowest in mining sites (15%), and highest in transportation sites (35%) and mid-value for mixed sites (24%). Thus, risk level gets magnified due to addition of finer dust generated in transportation and mixed sites than mining due to diesel driven vehicles. Burning of any fossil fuel generates high percentage of finer dust (< 2.5 µm).

Conclusions
There should be proper prescribed standard for silica for non-occupational conditions.
Clinical effectiveness of care managers in collaborative primary health care for patients with depression: 12- and 24-month follow-up of a pragmatic cluster randomized controlled trial
Authors: af Winklerfelt Hammarberg Sandra , Björkelund Cecilia , Nejati Shabnam , Magnil Maria , Hange Dominique , Svenningsson Irene , Petersson Eva-Lisa , André Malin , Udo Camilla , Ariai Nashmil , Wallin Lars , Wikberg Carl , Westman Jeanette 
Published: August 2022

Abstract
Background
In previous studies, we investigated the effects of a care manager intervention for patients with depression treated in primary health care. At 6 months, care management improved depressive symptoms, remission, return to work, and adherence to anti-depressive medication more than care as usual. The aim of this study was to compare the long-term effectiveness of care management and usual care for primary care patients with depression on depressive symptoms, remission, quality of life, self-efficacy, confidence in care, and quality of care 12 and 24 months after the start of the intervention.

Methods
Cluster randomized controlled trial that included 23 primary care centers (11 intervention, 12 control) in the regions of Västra Götaland and Dalarna, Sweden. Patients ≥18 years with newly diagnosed mild to moderate depression (n = 376: 192 intervention, 184 control) were included. Patients at intervention centers co-developed a structured depression care plan with a care manager. Via 6 to 8 telephone contacts over 12 weeks, the care manager followed up symptoms and treatment, encouraged behavioral activation, provided education, and communicated with the patient’s general practitioner as needed. Patients at control centers received usual care. Adjusted mixed model repeated measure analysis was conducted on data gathered at 12 and 24 months on depressive symptoms and remission (MADRS-S); quality of life (EQ5D); and self-efficacy, confidence in care, and quality of care (study-specific questionnaire).

Results
The intervention group had less severe depressive symptoms than the control group at 12 (P = 0.02) but not 24 months (P = 0.83). They reported higher quality of life at 12 (P = 0.01) but not 24 months (P = 0.88). Differences in remission and self-efficacy were not significant, but patients in the intervention group were more confident that they could get information (53% vs 38%; P = 0.02) and professional emotional support (51% vs 40%; P = 0.05) from the primary care center.

Conclusions
Patients with depression who had a care manager maintained their 6-month improvements in symptoms at the 12- and 24-month follow-ups. Without a care manager, recovery could take up to 24 months. Patients with care managers also had significantly more confidence in primary care and belief in future support than controls.

Trial registration
ClinicalTrials.gov identifier: NCT02378272. Submitted 2/2/2015. Posted 4/3/2015.
Effect of recombinant LH supplementation timing on clinical pregnancy outcome in long-acting GnRHa downregulated cycles
Authors: Huang Chenyang , Shen Xiaoyue , Mei Jie , Sun Yanxin , Sun Haixiang , Xing Jun 
Published: August 2022

AbstractBackgroundTimely and moderate luteinizing hormone (LH) supplementation plays positive roles in in vitro fertilization/intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET) cycles with long-acting gonadotropin-releasing hormone agonist (GnRHa) pituitary downregulation. However, the appropriate timing of LH supplementation remains unclear.MethodsWe carried out a retrospective cohort study of 2226 cycles at our reproductive medicine centre from 2018 to 2020. We mainly conducted smooth curve fitting to analyse the relationship between the dominant follicle diameter when recombinant LH (rLH) was added and the clinical pregnancy outcomes (clinical pregnancy rate or early miscarriage rate). In addition, total cycles were divided into groups according to different LH levels after GnRHa and dominant follicle diameters for further analysis.ResultsSmooth curve fitting showed that with the increase in the dominant follicle diameter when rLH was added, the clinical pregnancy rate gradually increased, and the early  miscarriage rate gradually decreased.ConclusionsIn long-acting GnRHa downregulated IVF/ICSI-ET cycles, the appropriate timing of rLH supplementation has a beneficial impact on the clinical pregnancy outcome. Delaying rLH addition is conducive to the clinical pregnancy rate and reduces the risk of early miscarriage.
Whole genome non-invasive prenatal testing in prenatal screening algorithm: clinical experience from 12,700 pregnancies
Authors: Baranova Elena E. , Sagaydak Olesya V. , Galaktionova Alexandra M. , Kuznetsova Ekaterina S. , Kaplanova Madina T. , Makarova Maria V. , Belenikin Maxim S. , Olenev Anton S. , Songolova Ekaterina N. 
Published: August 2022

AbstractBackgroundA fast adoption of a non–invasive prenatal testing (NIPT) in clinical practice is a global tendency last years. Firstly, in Russia according a new regulation it was possible to perform a widescale testing of pregnant women in chromosomal abnormality risk. The aim of the study—to assess efficiency of using NIPT as a second-line first trimester screening test in Moscow.MethodsBased on the first trimester combined prenatal screening results 12,700 pregnant women were classified as a high-risk (cut-off ≥ 1:100) and an intermediate-risk (cut-off 1:101 – 1:2500) groups followed by whole genome NIPT. Women from high-risk group and those who had positive NIPT results from intermediate-risk group were considered for invasive prenatal diagnostic.Results258 (2.0%) samples with positive NIPT results were detected including 126 cases of trisomy 21 (T21), 40 cases of T18, 12 cases of T13, 41 cases of sex chromosome aneuploidies (SCAs) and 39 cases of rare autosomal aneuploidies (RAAs) and significant copy number variations (CNVs). Statistically significant associations (p < 0.05) were revealed for fetal fraction (FF) and both for some patient’s (body mass index and weight) and fetus’s (sex and high risk of aneuploidies) characteristics. NIPT showed as a high sensitivity as specificity for common trisomies and SCAs with an overall false positive rate 0.3%.ConclusionsNIPT demonstrated high sensitivity and specificity. As a second-line screening test it has shown a high efficiency in detecting fetus chromosomal anomalies as well as it could potentially lower the number of invasive procedures in pregnant women.
Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in Australian primary care patients: only part of the story?
Authors: Orji Nneka , Campbell Julie A. , Wills Karen , Hensher Martin , Palmer Andrew J. , Rogerson Melissa , Kelly Ryan , de Graaff Barbara 
Published: August 2022

Abstract
Background
ME/CFS is a disorder characterized by recurrent fatigue and intolerance to exertion which manifests as profound post-exertional malaise. Prevalence studies internationally have reported highly variable results due to the 20 + diagnostic criteria. For Australia, the prevalence of ME/CFS based on current case definitions is unknown.

Objectives
To report prevalence of ME/CFS in patients aged ≥ 13 years attending Australian primary care settings for years 2015–2019, and provide context for patterns of primary care attendance by people living with ME/CFS.

Methodology
Conducted in partnership with the Patient Advisory Group, this study adopted a mixed methods approach. De-identified primary care data from the national MedicineInsight program were analyzed. The cohort were regularly attending patients, i.e. 3 visits in the preceding 2 years. Crude prevalence rates were calculated for years 2015–2019, by sex, 10-year age groups, remoteness and socioeconomic status. Rates are presented per 100,000population (95% confidence intervals (CI)). Qualitative data was collected through focus groups and in-depth 1:1 interview.

Results
Qualitative evidence identified barriers to reaching diagnosis, and limited interactions with primary care due to a lack of available treatments/interventions, stigma and disbelief in ME/CFS as a condition.
In each year of interest, crude prevalence in the primary care setting ranged between 94.9/100,000 (95% CI: 91.5–98.5) and 103.9/100,000 population (95%CI: 100.3–107.7), equating to between 20,140 and 22,050 people living with ME/CFS in Australia in 2020. Higher rates were observed for age groups 50-59 years and 40-49 years. Rates were substantially higher in females (130.0–141.4/100,000) compared to males (50.9–57.5/100,000). In the context of the qualitative evidence, our prevalence rates likely represent an underestimate of the true prevalence of ME/CFS in the Australian primary care setting.

Conclusion
ME/CFS affects a substantial number of Australians. Whilst this study provides prevalence estimates for the Australian primary care setting, the qualitative evidence highlights the limitations of these. Future research should focus on using robust case ascertainment criteria in a community setting. Quantification of the burden of disease can be used to inform health policy and planning, for this understudied condition.
Structural validity of the Brazilian version of the Sense of Coherence scale (SOC-13) in oral health research: exploratory and confirmatory factor analysis
Authors: Celeste Roger Keller , Scalco Giovana Pereira , Abegg Claides , Pattussi Marcos Pascoal , Ely Helenita Correa , Davoglio Rosane Silvia , do Carmo Matias Freire Maria 
Published: August 2022

Abstract
Background
The Sense of Coherence (SOC) construct has been used worldwide in oral health research, but rigorous factor analyses of the scale are scarce. We aim to test the dimensional structure of the Brazilian short version of the SOC scale with 13 items.

Methods
This study is a secondary analysis of four independent cross-sectional Brazilian studies on oral health, using the 13-items SOC scale. Sample 1 was conducted on 1760 mothers and 1771 adolescents. Sample 2 comprised 1100 adults. Sample 3 had 720 adults and older individuals. Sample 4 comprised 664 adolescent students. Confirmatory Factor Analysis (CFA) was conducted on sample 1 to compare two models: 3-factor versus 1-factor. Because they were refuted, Exploratory Factor Analysis was implemented in samples 2 and 3. Modified models were tested in sample 4 using CFA. All analyses were conducted with MPlus version 7.11.

Results
CFA of sample 1 resulted in an unacceptable fit (RMSEA = 0.12;CFI = 0.78; TLI = 0.73; and WRMR = 3.28) for 1-factor model and 3-factor (RMSEA = 0.10; CFI = 0.87; TLI = 0.84; and WRMR = 2.50). The EFA on samples 2 and 3 showed, respectively, two eigenvalues greater than 1 (4.11 and 1.56) and (4.32 and 1.42), but the scale items soc1, soc2 and soc3 formed an uninterpretable second factor. Another CFA, using sample 4, showed acceptable model fit after removing those three items and also soc11 (RMSEA = 0.05; CFI = 0.98; TLI = 0.99; and WRMR = 0.71).

Conclusion
The results indicate that the SOC-13 scale needs further adjustments. The one-factor model with nine items showed a good statistical fit, but the implications of excluding items should be further investigated, considering the scale's content validity, cross-cultural adaptation and theoretical background.