bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiological and clinical profile of suicide attempts in Tunisian adolescents
Authors: Boukhchina R. , Aissa A. , Kammoun I. , Zgueb Y. , Madouri S. , Ouali U. , Jomli R. 
Published: September 2022

IntroductionSuicidal behavior remains an important clinical problem and a major cause of death in youth.ObjectivesThe purpose of this study was to describe the epidemiological and clinical profile of adolescents with suicide attempts.MethodsThis is a retrospective descriptive study that focused on a population of Tunisian adolescents aged between 10 and 19 years old and who were hospitalized after a suicide attempt between between January, 1st 2010 and November,15th 2018, in Razi Hospital.We used a pre-established questionnaire that explored the sociodemographic and clinical data of patients.ResultsSixty adolescents were included in this study. The average age of the respondents was 14.3±2 years. The sex-ratio (m/f
) was 0, 36. The suicidal adolescent was a female (73%), single (98%), enrolled in school (66%) with school failure history (52%). Family history of suicide was reported in 8%. Fifty adolescents (83%) lived with their parents and the relationship with them was described as disturbed in 60% of them. A history of physical and sexual abuse was reported in 25% during first adolescence and 15% during second adolescence. The most frequent diagnoses were adjustment disorder with depressed mood (45%) and depression (28%). Drug ingestion was the most common mean of suicide (63%), in an impulsive way in 82% of cases.ConclusionsDevelopment of repeated epidemiological surveys makes it possible to better understand the prevalence of suicide attempts in adolescents and to implement suicide prevention programs.DisclosureNo significant relationships.
Experience in the Child/Youth Mental Health Centre of Leganés (Madrid) during the first lockdown
Authors: Díez Valle B. , De La Fuente Cabrero S. , Martín Roldán A. , Zurita Zarco C. 
Published: September 2022

IntroductionThe municipality of Leganés has been very vulnerable to the effects of the crisis derived from the COVID-19 pandemic (both due to the incidence of the infection and the socioeconomic situation). Multiple studies show that children and adolescents, especially those with a psychiatric background, have been one of the most affected groups during the confinement.ObjectivesFirstly, to describe the characteristics of clinical care at the Child/Youth Mental Health Centre of Leganés (Madrid) during the first lockdown (March-June 2020). Secondly, to present data on the clinical evolution of the patients along this period (n = 720).MethodsDescriptive study and literature review.ResultsClinical care during the period of strict confinement was mainly by telephone, although the most serious cases were attended in person. In addition, referral to Intensive outpatient programs was interrupted. The results show 56% of patients remained stable. Anxious symptoms (35%) and behavioural disturbances (24%) were most frequently referred (Figure 1), It is noteworthy that the most critical cases (such as suicide attempts or domestic violence) were observed in adolescents and that at least 11% of patients increased their use of electronic devices.ConclusionsThe first confinement stage was particularly stressful for families and especially for children and adolescents, although most patients remained psychopathologically stable. However, other studies have found a significant increase in child and adolescent mental health problems during the following months (de-escalation stage).DisclosureNo significant relationships.
Does Vitamin D matter? The role of calcium homeostasis imbalance in clinical severity of psychiatric patients
Authors: Altucci G. , Giannelli L. , Palummo C. , Di Cerbo A. , Agnese S. , Cipolla S. , Fabrazzo M. , Perris F. , Catapano F. , Luciano M. , Sampogna G. , Fiorillo A. 
Published: September 2022

IntroductionVitamin D modulates the biosynthesis of neurotransmitters and neurotrophic factors and it is involved in the modulation of inflammatory responses, with a potential impact on clinical status of patients with severe mental disorders. Moreover, available evidences report that decreased blood levels of Vitamin D are associated to a worse course of psychotic and affective disorders.ObjectivesWe assessed calcium homeostasis imbalance in a sample of inpatients and outpatients, referring to the Department of Psychiatry of University of Campania “Luigi Vanvitelli” in order to explore levels of Calcium, PTH and Vitamin D and their influence in clinical severity among this different subgroups.MethodsAll patients were administered The Brief Psychiatric Rating Scale (BPRS) to assess different domains of psychopathology. Vitamin D, Calcium and PTH levels were assessed in all patients. An-ad hoc schedule was administered for socio-demographic and clinical characteristics.ResultsThe total sample consisted of 152 patients (75 males and 77 females with 47.3 ± 14.4 age at admission, 74 inpatients and 78 outpatients). Patients with lower level of Vitamin D are more likely to present higher number of relapses (p<0.05) and to be inpatients (<0.01). Finally, serum levels of Vitamin D were negatively correlated with all the BPRS subscales (p < 0.01).ConclusionsLower levels of Vitamin D correlate with a worse clinical outcome of patients with different psychiatric diagnosis. Our results highlight the importance to routinely assess PTH, Vit D and calcium levels, especially in inpatients. Moreover, Vitamin D may represent a valid add-on treatment for these patients.DisclosureNo significant relationships.
Impact of serotonin transporter (SERT) binding affinity on the risk of libido disorders related to antidepressants
Authors: Zeiss R. , Gahr M. , Graf H. 
Published: September 2022

IntroductionSexual dysfunction is a frequent adverse drug reaction (ADR) of antidepressants that considerably affects quality of life and adherence to therapy. We previously investigated the potential underlying neurofunctional mechanisms by neuroimaging methods and revealed a dampening of the dopaminergic mesolimbic-mesocortical reward system along with decreased sexual functioning under serotonergic antidepressants compared to placebo.ObjectivesWithin a combined pharmacoepidemiologic and pharmacodynamic approach, we examined the association between serotonin transporter (SERT) affinity of various antidepressants and corresponding alterations in sexual desire as ADR.MethodsUsing disproportionality analyses, reporting odds ratios (RORs) were calculated for reports indicating decreased sexual desire as ADR under the antidepressants. The data were extracted from the WHO global database of individual case safety reports VigiBase and several MedDRA terms were grouped for “Sexual Desire Disorders”. For the pharmacodynamic assessment, we calculated Pearson correlation coefficients between SERT affinity and corresponding RORsResults16 signals were detected for “Sexual Desire Disorders”. We observed a statistically significant (r (20) =. 65, p = 0.001) association between SERT affinity and decreased sexual desire. Higher SERT affinity was associated with higher risk of sexual desire.ConclusionsWhile sexual dysfunctions under serotonergic medication were previously described, we now elaborated that in particular attenuated sexual desire as ADR is associated with SERT affinity of the antidepressant. These results strengthen our previously described neurofunctional model regarding sexual dysfunction under antidepressant medication and indicate that the specific SERT affinity of the antidepressant drug should be considered in clinical practice to minimize the risk of this ADR.DisclosureNo significant relationships.
Beyond pain: a study on the variance of pain thresholds within BDSM interactions in dominants and submissives
Authors: Wuyts E. , De Neef N. , Coppens V. , Schuerewegen A. , De Zeeuw-Jans I. , Van Der Pol M. , Morrens M. 
Published: September 2022

IntroductionBDSM is an acronym describing bondage & discipline, dominance & submission and sadism & masochism. Afflicting or receiving pain is usually an important part of the BDSM interaction.ObjectivesThis research focuses on better understanding the aspect of pain within a BDSM interaction by investigating the differences in 1) baseline pain thresholds, 2) the impact of a BDSM interaction on those thresholds and 3) threshold moderating factors like pain cognition between submissive and dominant BDSM participants and control individuals.MethodsSubmissive and dominant counterparts of 35 couples were recruited to participate in a BDSM interaction, of which 34 dominants and 33 submissives were included in analyses. A non-BDSM interested control group (n=27) was included to control for social interaction, of which 24 were included in analyses. Pain threshold measurements were measured at three points in time and pain cognitions scales were taken.ResultsBDSM practitioners have a higher pain threshold overall and a BSDM interaction will result in a temporary elevation of pain thresholds for submissives. Additionally, pain thresholds in dominants will be dependent upon their fear of pain and tendency to catastrophize pain and submissives will experience less fear of pain than the control group.ConclusionsThis study helps shed further light on the biological processes behind a BDSM interaction through pain threshold measurements. By enhancing our understanding of the mechanisms behind a BDSM interaction in this way, we aspire to relieve the stigma these practitioners still endure.DisclosureNo significant relationships.
The Genetic Underpinnings of Affective Temperaments: Identifying Novel Risk Variants with a Whole Genome Analytical Approach
Authors: Gonda X. , Eszlari N. , Torok D. , Gal Z. , Millinghoffer A. , Antal P. , Juhasz G. , Bagdy G. 
Published: September 2022

One reason behind the failure to understand the neurobiological background of affective disorders and develop more effective treatments is their heterogeneity warranting identification of clinically meaningful endophenotypes. Affective temperaments, considered subclinical manifestations and pathoplastic contributors of affective illnesses may constitute such endophenotypes. 775 general population subjects were phenotyped for affective temperaments using TEMPS-A, and genotyped using Illumina’s CoreExom PsychChip yielding 573141 variants. Primary SNP-based association tests were calculated using linear regression models assuming an additive genetic effect with the first 10 calculated principal components, gender, age, and other affective temperaments as covariates; a Bonferroni-corrected genome-wide significance threshold set at p≤5.0×10−8, and suggestive significance threshold set at p≤1.0x10-5. SNP-level relevances were aggregated to gene-level with the PEGASUS method, with a Bonferroni-corrected significance level set at 2.0×10-6, and suggestive significance thrshold set at p≤4.0×10-4. Functional effects of most significant SNPs as reported in public open databases based on expression quantitative trait loci (eQTL) and 3D-chromatin interactions were explored using FUMA v1.3.5. In SNP-based tests a novel genome-wide significant variant, rs3798978 (p=4.44x10-8) and several other suggestively significant SNPs in ADGRB3 were found for anxious temperament along with suggestively significant SNPs for the other four affective temperaments. In gene-based tests suggestively significant findings emerged for all five temperaments. Functional analysis suggested that several of the identified variants influence gene-expression levels or participate in chromatin interactions in brain areas implicated in affective disorders. In the next step these findings should be investigated in patient samples, and in other models of affective disorders and related phenotypes.DisclosureNo significant relationships.
The sexual function of women with epilepsy: a comparative study
Authors: Sayari N. , Maamri A. , Charaa O. , Tajmout A. , Hajri A. , Zalila H. 
Published: September 2022

IntroductionEpilepsy is a neurological disease that interferes negatively with many areas of the patient’s life. Sexual dysfunction is a frequent comorbidity in epileptic patients. Quality of life is particularly affected in women, who are also culturally stigmatized because of their illness.ObjectivesTo assess the sexual function of women with epilepsy compared to healthy women.MethodsThis was a case-control study of female patients with generalized epilepsy, carried out at the national institute of neurology in Tunisia in 2018. The controls were the patients’ companions in the department. They were matched by age with the cases. Sexual function was assessed by the female sexual function index (FSFI).ResultsWe included 40 cases and 40 controls.Their averge age was 30.45years. In comparison to the controls,the women with epilepsy had less kids ( p=0.04) and more miscarriages (p=0.032). On the other hand, women with epilepsy presented more sexual dysfunctions (p=0. 03) and had a lower total score on the FSFI (p=0.015) as well as significantly lower scores in the domains “desire” (p=0.009), “orgasm” (p=0.026), “satisfaction” (p=0.001) and pain (p=0.015).ConclusionsThe findings of this study are consisting with the literature, the women with epilepsy in this survey had impaired sexual function. More attention should be paid to these sexual disorders, previously considered secondary or even neglected.DisclosureNo significant relationships.
Premature ejaculation and stress
Authors: Sajdlova R. , Fiala L. 
Published: September 2022

IntroductionRecent findings indicate that men with premature ejaculation report more frequent sexual problems associated with increased anxiety and interpersonal difficulties. Also the neuroendocrine changes were examined and compared to other indicators of stressful experiences.ObjectivesPremature Ejaculation (PE) is defined as an ejaculation occurring within one minute after the start of sexual intercourse and occurs in 20-30% of men. They report frequent problems with partnerships and increased anxiety, irritability and orgasmic dysfunction. Premature ejaculation is likely to be associated with decreased serotonergic neurotransmission and higher levels of leptin. Also the role of hyperactive thyroid and prostate disease was investigated. On the other hand there is no evidence as to how previous stressful experience and distrubed partnership might contribute PE.MethodsOur study comprised 60 male outpatients diagnosed as having secondary premature ejaculation. Clinical examinations were focused on biochemical analysis of cortisol and psychometric scoring using a diagnostic tool for premature ejaculation, traumatic stress and somatoform dissociation. The control group consisted of a 60 healthy men.ResultsThe results showed significant Spearman correlations of the Premature Ejaculation Diagnostic Tool score with Trauma symptoms checklist score (R=0.86), cortisol level (R=0.47) and Somatoform dissociation questionnaire score (R=0.61). In the control group, the results did not reach statistical significance. Spearman correlations of the Premature Ejaculation Diagnostic Tool score with Trauma symptoms checklist score was (R=0.21), cortisol (R=0.27) and with Somatoform dissociation questionnaire score (R=0.25).ConclusionsThese results represent the first reported findings documenting the relationship of traumatic stress indicators with the experience of secondary premature ejaculation and cortisol levels.DisclosureNo significant relationships.
Sexual dysfunctions among men with paroxysmal or persistent atrial fibrillation - a two-center study in the Polish population
Authors: Szczegielniak A. , Smolarczyk- Kosowska J. , Wybraniec M. , Krzystanek M. 
Published: September 2022

IntroductionThere are no comprehensive studies on sexual dysfunctions among people with paroxysmal and persistent atrial fibrillation after excluding concomitant somatic and mental disorders, even though their presence has a significant impact on observed changes in sexual activity and behaviour. Most of the available studies among males are focused on erectile dysfunction due to well established relationship of it with the occurrence of cardiovascular disorders in the future.ObjectivesThe aim of the study was to assess the prevalence of sexual disorders among male patients treated for paroxysmal and persistent atrial fibrillation.MethodsThe study group included 54 men diagnosed with paroxysmal and persistent atrial fibrillation, qualified for electrical cardioversion and/or ablation of circumferential pulmonary vein, not burdened with additional somatic diseases. The control group consisted of 55 men matched in terms of sex, age and health condition. The study used standard CSFQ-14 sexuality assessment questionnaires, and the WHOQoL-BREF quality of life survey. Mental status examination was performed to exclude those with mental disorders, currently or in the past receiving psychiatric and/or addiction treatment.ResultsThe analysis of the survey studies showed that among the surveyed men with paroxysmal and persistent atrial fibrillation, the prevalence of sexual problems is high (61.1% study group vs 47.3% control group). There were significant differences between the study group with lower sexual function scores in pleasure, desire/interest, arousal/erection, orgasm/ejaculation, and in the overall CSFQ-14’s score. The desire/frequency ratio did not differ between the groups.ConclusionsComprehensive care requires the assessment of sexual satisfaction and the presence of possible dysfunctions using standardized tools.DisclosureNo significant relationships.
Sexuality in ADHD: empirical data concerning hypersexual and paraphilic fantasies and behaviors in adults with ADHD
Authors: Gregório Hertz P. , Turner D. , Retz W. 
Published: September 2022

IntroductionADHD is a neurodevelopmental disorder displaying inattention, hyperactivity, and impulsivity as core symptoms. It can affect several areas of life including sexual health. Clinicians have often made assumptions concerning the bound of specific ADHD symptoms affecting sexual desire by increasing its frequency and intensity. Yet, there is still a lack of knowledge about the comorbidity between ADHD, hypersexuality, and paraphilias. A recent literature review could show that some individuals who suffer from ADHD report about hypersexual and paraphilic fantasies and behaviors, but as far as we know, no clear empirical data has emerged supporting the idea that hypersexuality and paraphilias are more frequent in individuals with ADHD.ObjectivesThe present investigation aimed to compare several sexuality related aspects between individuals with and without ADHD.MethodsTherefore, we designed an extensive online survey based on established questionnaires, such as the Hypersexual Behavior Inventory (HBI). The survey was implemented in a outpatient sample, ADHD specific fora as well as other general online channels.ResultsIn total, N = 238 individuals participated in the survey (n = 160 with ADHD). Thereby, individuals with ADHD reported significantly more often about a wide range of hypersexual fantasies and behaviors in comparison to individuals without ADHD. Furthermore, individuals with ADHD reported significantly more often about paraphilic fantasies and behaviors including fetishistic and sadistic sexual fantasies. No differences were found concerning other paraphilias. Further results regarding other facets of sexuality, such as sexual orientation, are to be presented and discussed.ConclusionsThe present study contributes to closing the knowledge gap regarding sexuality in individuals with an ADHD.DisclosureNo significant relationships.
Effects of paramedical counselling on anxio-depressive symptoms, perceived stress and self-esteem in male factor infertility
Authors: Szatmári A. , Helembai K. , Zádori J. , Kovács I. 
Published: September 2022

IntroductionElevated levels of anxio-depressive symptoms and perceived stress are widely researched in case of female factor infertility; however, there is scant information on their emergence in case of male factor infertility.ObjectivesThe aim of the present study is to assess whether a 5-course paramedical counselling accompanying infertility treatment would have a decreasing impact on anxio-depressive symptom severity and perceived stress and would increase the level of self-esteem in infertile men.Methods108 patients were divided into control (n = 51) and experimental (n = 57) groups, where the latter participated in the aforementioned paramedical counselling. Anxio-depressive symptom severity was measured with the Beck Depression Inventory and the Spielberger’s State Anxiety Inventory; perceived stress was registered with the Perceived Stress Scale and Brief Stress and Coping Inventory, while self-esteem was evaluated by the Rosenberg Self-Esteem Scale.ResultsParticipation in an infertility programme itself affected positively patients’ self-esteem and decreased their levels of depressive symptom severity (t(50) = 2.738, p = 0.009, 95%CI = 0.167 – 1.088), but an additional 5-session paramedical counselling resulted in a significant lowering of state anxiety symptoms (t(106) = -2.093, p = 0.039, 95%CI = -6.372 – 0.173) contrasted with infertile men not receiving this additional counselling.ConclusionsConclusion: Screening for psychological factors is advisable in the course of an infertility treatment, and the implementation of an accompanying paramedical counselling focusing on the alleviation of concomitant psychopathological symptoms would be advisable among male infertile patients.DisclosureNo significant relationships.
ADHD in Prisoners
Authors: Ginsberg Y. 
Published: September 2022

The risk rate of criminality is increased in ADHD, especially in children who, in addition to ADHD, express externalizing behavior of oppositional defiant disorder (ODD), later followed by conduct disorder (CD), substance misuse and antisocial personality disorder (ASPD). Studies report ADHD to be about ten times more common in prison populations than in the general adult population. Prisoners with ADHD have compared to prisoners without ADHD, an earlier onset of offending, higher rates of coexistent psychiatric disorders, and are more often incarcerated due to violent- and drug-related offences. Within prison settings, inmates with ADHD are more often reported for intra-institutional aggression and they are often experienced as more difficult to manage and costly to rehabilitate. Further, they relapse comparably more often and faster into criminality after being conditionally released. Despite high prevalence rates of ADHD within prisons and serious consequences related to untreated ADHD, few controlled trials have evaluated methylphenidate treatment in prisoners with ADHD and coexistent disorders. Evidence and clinical experience of pharmacological and psychosocial interventions of prison populations with ADHD will be presented briefly.DisclosureNo significant relationships.