bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptional programs controlling lineages specification of mandibular epithelium during tooth initiation
Authors: Shao Fan , Phan An-Vi , Van Otterloo Eric , Cao Huojun 
Published: November 2022

ABSTRACTTooth development starts with formation of the dental lamina, a localized thickening of the maxillary and mandibular epithelium, at specific location of oral cavity. How this dental lamina is specified within the continuous naïve maxillary and mandibular epithelium, remains as a critical and unresolved question. To identify potential genes and transcriptional regulatory networks that controlling dental lamina formation, we utilized single-cell Multiome-seq and Laser Microdissection coupled RNA-seq to profile gene expression and open chromatin of mandibular epithelium during tooth initiation. We comprehensively identified transcription factors (TFs) and signaling pathways that are differentially expressed among different domains (including dental lamina) along dorsal-ventral axis of mandibular epithelium. Specifically, we foundSox2andTfap2a/Tfap2bforming two complementary domains along the dorsal-ventral axis of mandibular epithelium. Furthermore, dental lamina specific or enriched TFs such asPitx1, Pitx2andZfp536are presented around the interface ofSox2andTfap2a/Tfap2b. We also identified correlation between signaling pathways and domain specific TFs. Through computational analysis of single-cell Multiome-seq dataset, we identified potential key/driver TFs and core transcriptional regulatory networks (TRNs) for lineages (oral, dental, skin) specification during tooth initiation. Our computational analysis also reveals a potential cross repression interactions between different groups of TFs (i.e.Pitx1/Pitx2andTfap2a/Tfap2b) that might be essential for dental lamina specification.
How to Develope a Novel 3D Printed Integral Customized Anatomical Acetabular Prosthesis in Hip Arthroplasty for Crowe Type II and III Developmental Dysplasia of the Hip?
Authors: Zhang Heng , Ma Xiaodong , Cheng Zengjing , Li Xuanxuan , Zhou Jiansheng , Zhao Jianning 
Published: December 2022

AbstractBackgroundThe acetabular pathomorphology in patients with Crowe type II and III developmental dysplasia of the hip(DDH)often present complicated changes, which bring challenges to the anatomical reconstruction of acetabulum in total hip arthroplasty (THA). The objective of this study was to develope a novel 3D printed integral customized acetabular prosthesis, which provides a promising way to reconstruct the acetabulum with higher accuracy and efficiency by digital softwares, compared with previous 3D printing model method.Methods15 patients (18 hips) with end-stage hip osteoarthritis due to Crowe type II/III DDH who underwent primary cementless THA from January 2015 to November 2021 were included. The 15 patients consisted of 3 men (3 hips) and 12 women (15 hips) with an average age of 53.89 ± 8.48 years (range from 32 to 69 years). The novel 3D printed integral customized acetabular prosthesis was designed by the model method and software method respectively. The indicators of the cup size, the volume and superficial area of bone defect, the inclination and anteversion of acetabular cup, the horizontal and vertical distance of hip center and working time were compared between two methods.ResultsThere were statistically significant difference between the software group and model group on the volume and superficial area of bone defect as well as working time (t = 2.397, 2.707,138.509, P < 0.05). The mean anteversion and inclination of acetabular cup in the software group and model group were(15.17±0.52)°,(40.24±0.58)°and (33.79 ±13.43)°, (30.50 ±11.03)°respectively, the difference was statistically significant (t = 5.859, 3.767, P < 0.05).There were no statistically significant difference between the software group and model group on cup size, the horizontal and vertical distance of hip center(t =1.458,0.114, 1.712, P > 0.05)ConclusionsThe application of digital softwares could design and develope the novel 3D printed integral customized anatomical acetabular prosthesis in THA for □Crowe type II and III DDH with high accuracy and efficiency.
Different tissues in the maternal-fetal interface harbor distinct microbiomes showing associations related to their anatomical position or function
Authors: Li Xiaopeng , Jiang Wei , Dai Lijuan , Liu Guihong , Yu Bolan , Fang Min 
Published: December 2022

ABSTRACTThe human placenta was thought to be sterile in healthy pregnancies which has been challenged by the development of DNA sequence-based techniques, although it is still open to controversy. Nonetheless, little is known whether different parts of fetal appurtenances contain district microbiome profiles. Here, DNA 16S rRNA sequencing was performed of the amniotic fluid cells (AC), amnion membrane (AM), the placenta of fetal surface (remove the amniotic membrane, PL), maternal blood (MB), and umbilical cord blood (UCB) at V3-V4 hypervariable region from participants with cesarean delivery. Then sequence raw data were followed by taxonomic classification at 97% similarity and diversity analysis at the genus level. The differences and associations among the five tissues were analyzed. At the phylum composition level, the most abundant microorganisms were Proteobacteria in all five tissues, and followed by Firmicutes in AC, AM, and MB groups, Actinobacteria in UCB and Bacteroidetes in PL, respectively. As the maternal-fetal barrier, PL and AM had the lower OUT number and weaker co-occurrence network compared with the other three tissues. At the beta diversity clustering level, the microbiota constituents in the MB and UCB were highly similar; the microbiota profiles of PL and AM were also remarkably alike; AC was immensely different from those two clusters. Therefore, the five tissues were distinctly separated into three clusters. Our study reveals that different pregnancy-related anatomical sites harbor unique microbial compositions and show different degrees of correlation with other tissues.
How absorptive capacity influences project performance
Authors: Dultra-de-Lima Ronaldo Gomes , Brito Luiz Artur Ledur 
Published: November 2022

PurposeThe absorptive capacity (AC) leads to firm performance and influences the development and evolution of capabilities and routines, but the influence of AC in projects remains unclear. Therefore, this study aims to investigate the effect of AC on project performance (PP) in the construction industry of Sao Paulo State, Brazil.Design/methodology/approachThe authors conducted a survey questionnaire with project managers and collected 157 responses in the construction sector. They also used confirmatory factor analysis (CFA) and multiple linear regression techniques to assess the data.FindingsThe study provides empirical evidence that realized absorptive capacity (RAC) has a direct and indirect positive effect on PP. Conversely, the potential absorptive capacity (PAC) only indirectly impacts PP through project management practices (PMPs). PAC and RAC positively influence PMPs that in turn positively influence PP. The findings reinforce the relevance of AC to the development of internal knowledge for processes and routines, thereby enhancing PP.Practical implicationsThe findings provide practical implications: the AC influences PP by refining and adapting routines. Moreover, the consistent application of accepted practices is not enough for PP, but the ability to adapt, adjust and transform the relevant knowledge into routines.Originality/valueThis paper provides empirical evidence that the knowledge application of PMPs improves organizational performance through PP. However, despite what the literature has discussed, this paper proved that AC has no effect as a moderating factor between PMPs and performance; however, AC's role significantly impacts PP through PMPs.
Operation recovery: a feasibility study of an 8 week exercise and lifestyle programme within an Irish first episode psychosis service
Authors: Kearns Murphy Claire , Kemps Louise , McDonough Catherine , McDonough Suzanne 
Published: December 2022

Purpose
Early interventions focusing on exercise and lifestyle are important for individuals with a diagnosis of psychosis due to increased risk of poor physical health and reduced life expectancy. This study aims to test the feasibility of a multicomponent lifestyle intervention for individuals with first episode psychosis (FEP).

Design/methodology/approach
Individuals attending an Irish FEP service were invited to engage in an eight-week programme including individual and group exercise sessions, group educational sessions and one dietician consultation. Physical activity, physical health, mental health, cognition and personal goals measures were completed pre- and post-intervention and analysed using descriptive statistics. Feasibility data was collected via a non-standardised participant questionnaire and informal data on completion of measures and engagement with the programme.

Findings
Ten participants with a diagnosis of FEP completed the intervention. Participants were satisfied with the intervention and adherence rates were high for weekly individual gym sessions but lower for group exercise and education sessions. Mean time spent engaging in physical activity increased and sedentary behaviours decreased. Participants indicated increased readiness for change with 90% moving to the action or maintenance stages of change. Participants attained 74% of their personal goals. There were no changes in average body mass index, cognition or mental health. Data relating to blood pressure, blood tests and steps was missing or incomplete.

Originality/value
This study indicates an eight-week exercise and lifestyle programme is feasible and acceptable in a clinical setting. Recommendations relating to satisfaction, clinical markers and resource requirements are made for future studies.
Intelligent prediction of wear life of automobile brake pad based on braking conditions
Authors: Cao Jingyu , Bao Jiusheng , Yin Yan , Yao Wang , Liu Tonggang , Cao Ting 
Published: December 2022

Purpose
To avoid braking accidents caused by excessive wear of brake pad, this study aims to achieve online prediction of brake pad wear life (BPWL).

Design/methodology/approach
A simulated braking test bench for automobile disc brake was used. The correlation and mechanism between the three braking condition parameters of initial braking speed, braking pressure and initial braking temperature and the tribological performance were analyzed. The different artificial neural network (ANN) models of wear loss were discussed. Genetic algorithm was used to optimize the ANN model. The structure scheme of the online prediction system of BPWL was discussed and completed.

Findings
The results showed that the braking conditions were positively correlated with the wear loss, but negatively correlated with the friction coefficient. The prediction accuracy of back propagation (BP) ANN model was higher. The model was optimized by genetic algorithm, and the average deviation of prediction results was 4.67%. By constructing the online monitoring system of automobile braking conditions, the online prediction of BPWL based on the ANN model could be realized.

Originality/value
The research results not only have important theoretical significance for the study of BPWL but also have practical value for guiding the maintenance and replacement of automobile brake pads and avoiding the occurrence of braking accidents.
Exploring the metaverse in the digital economy: an overview and research framework
Authors: Cheng Xusen , Zhang Shuang , Fu Shixuan , Liu Wanxin , Guan Chong , Mou Jian , Ye Qiongwei , Huang Caiming 
Published: December 2022

PurposeMetaverse is a virtual application spawned by digital technology that is becoming increasingly relevant to our lives. However, for the opportunities created and challenges posed by the metaverse, its important elements and future evolution trend remain largely unknown. Thus, this paper aims to understand the current status of metaverse research and its future research directions.Design/methodology/approachBased on the analysis of the literature data on the metaverse both in English and Chinese using Latent Dirichlet allocation (LDA) topic modeling and bibliometrics, this study discussed the related research and development trend of the metaverse. The authors first defined the concept of the metaverse and analyzed 1,378 English articles from seven publishers and 590 Chinese articles from the CNKI database. Following that, the authors summarized three important themes from the current studies: virtual world, metaverse technologies and metaverse applications. Finally, a framework of future directions on metaverse research was proposed.FindingsThe review found that during the rapid development of the metaverse, opportunities and challenges coexisted. In the virtual world, metaverse technologies drive the implementation of application scenarios, and in turn, applications promote the improvement of technologies. The interrelationship between technology and application lays the foundation for the development of the metaverse. Future metaverse research will generate different research directions.Originality/valueThis review provides a valuable, systematic perspective for individuals who want to understand the metaverse. The conceptual framework on metaverse research proposed in this paper offers a comparison of literature analysis from domestic and international perspectives and brings new insights into the development of the metaverse.
Women living with HIV, diabetes and/or hypertension multi-morbidity in Uganda: a qualitative exploration of experiences accessing an integrated care service
Authors: Van Hout Marie Claire Annette , Zalwango Flavia , Akugizibwe Mathias , Namulundu Chaka Moreen , Bigland Charlotte , Birungi Josephine , Jaffar Shabbar , Bachmann Max , Murdoch Jamie 
Published: December 2022

PurposeWomen experience a triple burden of ill-health spanning non-communicable diseases (NCDs), reproductive and maternal health conditions and human immunodeficiency virus (HIV) in sub-Saharan Africa. Whilst there is research on integrated service experiences of women living with HIV (WLHIV) and cancer, little is known regarding those of WLHIV, diabetes and/or hypertension when accessing integrated care. Our research responds to this gap.Design/methodology/approachThe INTE-AFRICA project conducted a pragmatic parallel arm cluster randomised trial to scale up and evaluate “one-stop” integrated care clinics for HIV-infection, diabetes and hypertension at selected primary care centres in Uganda. A qualitative process evaluation explored and documented patient experiences of integrated care for HIV, diabetes and/or hypertension. In-depth interviews were conducted using a phenomenological approach with six WLHIV with diabetes and/or hypertension accessing a “one stop” clinic. Thematic analysis of narratives revealed five themes: lay health knowledge and alternative medicine, community stigma, experiences of integrated care, navigating personal challenges and health service constraints.FindingsWLHIV described patient pathways navigating HIV and diabetes/hypertension, with caregiving responsibilities, poverty, travel time and cost and personal ill health impacting on their ability to adhere to multi-morbid integrated treatment. Health service barriers to optimal integrated care included unreliable drug supply for diabetes/hypertension and HIV linked stigma. Comprehensive integrated care is recommended to further consider gender sensitive aspects of care.Originality/valueThis study whilst small scale, provides a unique insight into the lived experience of WLHIV navigating care for HIV and diabetes and/or hypertension, and how a “one stop” integrated care clinic can support them (and their children) in their treatment journeys.
The effects of public service motivation, risk propensity and risk perception on defensive decision-making in public administrations
Authors: Schäfer Fabienne-Sophie , Hirsch Bernhard , Nitzl Christian 
Published: November 2022

PurposeDrawing on the literature on public service motivation, the authors investigate the relationship between public service motivation and defensive decision-making. Further, the authors explore risk propensity and risk perception as potential antecedents of defensive decision-making.Design/methodology/approachBased on survey data from 144 German public financial managers of municipalities and federal agencies, the authors find no significant direct relationship between public service motivation and defensive decision-making.FindingsHowever, the authors can show that risk propensity fully mediates the relationship between public service motivation and defensive decision-making. The findings also indicate that beyond the public service motivation and individual risk propensity of public financial managers, their risk perception does influence their decision making.Originality/valueThe study makes three contributions to the literature. First, the authors contribute to the relatively small amount of research on the risk-taking behaviour of public managers by explaining the indirect impact of PSM on their risk-taking behaviour. Second, this paper furthers the understanding of the influence of risk perception and risk propensity on decision-making and enhances the models of Sitkin and Pablo (1992) and Sitkin and Weingart (1995). Third, the paper also contributes to the call for more international research on German public administrations.
Health belief and behaviour: an analysis of the predictors for receiving COVID-19 vaccines in Malaysia
Authors: Tan Consilz , Liew Chee Yoong 
Published: November 2022

PurposeThe paper examines the ‘Intention to Receive the COVID-19 Vaccines’ or IRV from three perspectives: the health belief model, behavioural economics, and institutional quality.Design/methodology/approachThis study provides quantitative analysis by applying Chi-squared test of contingencies, paired sample t-tests, exploratory factor analysis, and multiple linear regression (stepwise method) on the data collected from 591 respondents mainly from Malaysia.FindingsThe results show that Perceived Benefits, Perceived Barriers, Perceived Susceptibility, Herding, and Institutional Quality play roles as predictors of IRV. Perceived Benefits play the most crucial role among the predictors and Perceived Barriers is the least important predictor. People have the herding mentality after being exposed to information encouraging such behaviour.Originality/valueThis study reveals that the respondents changed their behaviour in different circumstances when exposed to information that incorporates the effect of herding. Herding mentality, the effectiveness of government authorities, and regulatory quality have become important factors in enriching public health policies and the effectiveness of interventions.
Let us get contextual: critical realist case studies in supply chain management
Authors: Bille Amanda , Hendriksen Christian 
Published: December 2022

Purpose
This study aims to explain the value of using critical realist case research in supply chain management (SCM). While positivist case research focuses on generalizable law-like rules, and interpretivist research explores social meaning, critical realist case research seeks to make objective explanations that are bound by the case context. This study demonstrates how a critical realist synthesis of causal reasoning and contextual complexity allows for stronger theorizing in SCM.

Design/methodology/approach
This study highlights the possibilities of conducting critical realist case research in SCM by investigating philosophical perspectives in existing literature.

Findings
Based on existing literature, this study identifies which parts of contemporary SCM research will benefit from the critical realist perspective. This study also contends that supply chain scholars can use critical realist case research to develop new types of contextualized middle-range theories.

Research limitations/implications
This study proposes to complement the qualitative SCM toolbox with critical realist case research to further refine the development of novel theories. This will benefit not only researchers but also managers, as it opens the doors to new and inspiring research.

Originality/value
This study takes an important step toward establishing critical realist case studies as a key methodology in SCM. While other scholars have introduced critical realism as a paradigmatic approach in SCM, to the best of the authors’ knowledge, this is the first article that develops a qualitative critical realist case research approach.
Genetic diversity of rodent species sold in South African pet shops
Authors: Shivambu Ndivhuwo , Shivambu Tinyiko C. , Downs Colleen T. , Willows‐Munro Sandi 
Published: November 2022

AbstractMurid rodents are considered globally important invasive species, yet they are still sold in the pet trade. Little is known about the genetic diversity of traded rodents, and many species are incorrectly identified in the pet trade. We used mitochondrial gene regions to assess the taxonomy and genetic diversity of 149 rodents sold in pet shops across eight South African provinces. We identified a total of 112 specimens as Mus musculus, while 31 were Rattus norvegicus, and six were identified as the southern African endemic, southern multimammate mouse Mastomys coucha. Phylogenetic analyses revealed that the three species were monophyletic. Mus musculus and R. norvegicus showed higher levels of genetic diversity, with 19 unique mtDNA haplotypes recovered for M. musculus and eight haplotypes for R. norvegicus. KwaZulu‐Natal, Western Cape and Gauteng Provinces had the most unique haplotypes than other provinces. Our findings showed that non‐native species are widely distributed in the South African pet trade industry, while M. coucha was not widely traded, although recorded in three provinces. This suggests that most provinces comply with the trade regulations on native species, but the threat of invasive rodents to South Africa's unique biodiversity is highlighted.
Decline of the marabou stork (Leptoptilos crumenifer) in West Africa and the need for immediate conservation action
Authors: Gula Jonah , Barlow Clive R. 
Published: November 2022

AbstractThe marabou stork (Leptoptilos crumenifer) is widespread and generally abundant in East and Southern Africa, but recent research has found range loss indicative of a population decline in West Africa in recent decades. In the absence of population data, we conducted an in‐depth review of the status of the marabou in the region using a plethora of sources together comprising the largest database on the occurrence of the species. Despite caveats and coarseness of the assessment, we estimate the range loss at 52% in West Africa, including extirpation of approximately 64% of known nesting colonies since 2000. The resulting fragmentation has left a metapopulation of likely no more than 100 breeding pairs in The Gambia and Benin and an unknown number of breeders in Cameroon. Knowledge gaps about marabou population ecology in West Africa are significant and prevent an empirical assessment of regional extinction probability. Therefore, we recommend immediate field surveys, especially for breeding colonies, and research into threats and population dynamics. We also recommend the West African metapopulation be listed as regionally critically endangered and that a working group be formed comprising stakeholders from across the region to aid in assessing threats and implementing research and conservation action.