bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental assessment in the prelaunch phase of Hayabusa2 for safety declaration of returned samples from the asteroid (162173) Ryugu: background monitoring and risk management during development of the sampler system
Authors: Sakamoto Kanako , Takano Yoshinori , Sawada Hirotaka , Okazaki Ryuji , Noguchi Takaaki , Uesugi Masayuki , Yano Hajime , Yada Toru , Abe Masanao , Tachibana Shogo ,   The Hayabusa2 Project Team
Published: June 2022

AbstractWe report ground-based environmental assessments performed during development of the sampler system until the launch of the Hayabusa2 spacecraft. We conducted static monitoring of potential contaminants to assess the environmental cleanliness during (1) laboratory work performed throughout the development and manufacturing processes of the sampler devices, (2) installation of the sampler system on the spacecraft, and (3) transportation to the launch site at the Japan Aerospace Exploration Agency’s (JAXA’s) Tanegashima Space Center. Major elements and ions detected in our inorganic analyses were sodium (Na), potassium (K), and ionized chloride (Cl–); those elements and ions were positively correlated with the total organic content and with exposure duration in the range from 101 to 103 nanograms per monitor coupon within an ~ 30-mm diameter scale. We confirmed that total deposits on the coupon were below the microgram-scale order during manufacturing, installation, and transportation in the prelaunch phase. The present assessment yields a nominal safety declaration for analysis of the pristine sample (> 5.4 g) returned from asteroid (162173) Ryugu combined with a highly clean environmental background level. We expect that the sample returned from Ryugu by Hayabusa2 will be free of severe and/or unknown contamination and will allow us to provide native profiles recorded for the carbonaceous asteroid history.
Graphical Abstract
Mapping the landscape and structure of global research on nutrition and COVID-19: visualization analysis
Authors: Zyoud Sa’ed H. , Al-Jabi Samah W. , Koni Amer , Shakhshir Muna , Shahwan Moyad , Jairoun Ammar A. 
Published: June 2022

Abstract
Background
Coronavirus disease 2019 (COVID-19) has had a significant influence on nutritional status. There have been several studies on dietary habits and nutritional status in connection with COVID-19. However, there has been no research on the bibliometric analysis of these papers. Therefore, our objective was to assess the most relevant scientific research on nutrition and COVID-19, as well as to assess current hot themes.

Methods
We obtained data from the Scopus database on June 30, 2021. Qualitative and quantitative analyzes were conducted based on the Scopus. Collaboration and term analysis was performed using VOSviewer software version 1.6.16.

Results
At the time of data collection, there were 177,946 documents in COVID-19. Scopus found 1885 articles related to nutrition and COVID-19 after narrowing the search to those terms. This includes 1309 (69.44%) research articles, 268 (14.22%) review papers, and 308 other types of document. The USA was the largest producer, with 24.83% of the documents, followed by Italy with 11.88% (n = 224), the UK with 10.82% (n = 204), and China with 7.59% (n = 143). The most active institution was Sapienza Università di Roma (n = 30, 1.59%). The leading journal in COVID-19 nutrition research was Nutrients (n = 115, 6.10%). The article with 310 citations published by Di Renzo et al. in 2020 was the most influential reference. The hot topics were stratified into three clusters: (1) “Food security in the COVID-19 pandemic”; (2) “nutritional determinants and COVID-19 outcomes”; and (3) “changes in dietary habits during the COVID-19 pandemic and its consequences”.

Conclusions
This is the first bibliometric research to offer comprehensive information on COVID-19 and nutrition in the published literature. Research will likely be helpful to scholars and policymakers. This study sheds light on the growth and development of nutrition and covid-19-related research and should contribute to the expansion of the global frontier in the major hot topics, including “food security in the COVID-19 pandemic”; “nutritional determinants and COVID-19 outcomes”; and “changes in diet habits during the COVID-19 pandemic and its consequences”.
“Help, Given in a Disinterested Manner”
Authors: Shonk Kenneth L. 
Published: June 2022

Abstract
Documents contained in the Department of Foreign Affairs files in the National Archives of Ireland reveal that many global anticolonial nationalists visited Ireland in the 1950s and 1960s. These files elucidate efforts by nationalists from Africa and Asia to emulate Ireland’s nation-building frameworks including its constitution, housing and charitable programs, educational structures, and burgeoning industries. This article uses these documents to examine hitherto unstudied aspects of Ireland’s place within larger transnational intellectual networks. This paper adds greater nuance to Jean-François Bayart’s thesis of extraversion by demonstrating that African and Asian anticolonial nationalists consciously and explicitly looked to Ireland as a model for nation-building. Emerging nations in the 1950s and 1960s sent representatives to Ireland to study the nation’s economic and political frameworks, in turn offering a space for a dialogic experience in which the emulation of Ireland was extraversion in a positive sense.
Renegotiating Ireland, Transnational History, and Settler Colonialism in White Australia
Authors: Yan Jimmy H. 
Published: June 2022

AbstractEfforts to transcend island histories in Irish historiography have predominantly centered a narration of white settler pasts as an outer boundary of Irish history. This article works through the disjunctions between differently situated transnational turns in Irish and Australian historiographies by interrogating metaphors of extension, including “Greater Ireland” in the former historiography. It proposes that to decenter the nation as a historical unit, transnational Irish history requires a critical tension with white settler, and not only Irish, methodological nationalisms. The article surveys the critical possibilities presented by the transnational turn in Irish historiography while questioning its limits, with attention to the paradigm of a transnational Irish revolution. It then flags possible directions for a closer dialogue between transnational Irish history and postnational historiographies of white settler colonialism. An unsettling of discrete historiographical boundaries remains a necessary condition for tracing histories of Ireland beyond, below, and outside the nation.
Apple and Ireland, 1980–2020
Authors: McCabe Conor 
Published: June 2022

Abstract
This article places the recent tax case concerning Apple Inc., Ireland, and the European Commission within its historical framework to reveal the very particular structural dynamics that exist between the Irish state and transnational capital. It proposes that these dynamics result not entirely from an industrial strategy adopted in the 1950s but instead from a deeper neocolonial economic relationship, itself part of a comprador capitalist system that is firmly embedded in key public and private institutions of the Irish state and socially reproduced through them. An understanding of this comprador dynamic and its ideological framework is essential to understanding why the Irish state protects tax avoidance above the interests of wider Irish society.
Rousseau's Toe
Authors: Stacey Jessica 
Published: June 2022

Abstract
This article suggests that we might find a new way to address two stubborn questions regarding Jean-Jacques Rousseau's Confessions through a single shift in perspective. These two questions are: What can we make of the antipathy that readers often feel toward this text, in response to the narrator's demand for total empathetic identification? And, how can we draw out the text's queer potential? Versions of these two questions have been asked many times by critics, but always in the register of unveiling, unmasking, exposing. What if, rather than deconstructing or diagnosing, we take an explicitly reparative position toward the paranoia that the text models, and toward the queer encounters it records? This approach involves seeking empathy away from where the text directs us, giving Rousseau a version of what he wants while challenging his tyrannical program that sets out how we should read and relate. Far from attempting to restore to the narrator the coherence or wholeness that myriad suspicious reads have undermined, this reparative reading counsels approaching the text as fragmentary archive. In the process, early modern queer identities, surface versus depth, and the Confessions as foundational text for modern autobiography—and the modern self—are all reconsidered.
ABI transcription factors and PROTEIN L-ISOASPARTYL METHYLTRANSFERASE module mediate seed desiccation tolerance and longevity in Oryza sativa
Authors: Kamble Nitin Uttam , Majee Manoj 
Published: June 2022

ABSTRACT
In contrast to desiccation-tolerant orthodox seeds, recalcitrant seeds are desiccation sensitive and are unable to survive for a prolonged time. Here, our analyses of Oryza species with contrasting seed desiccation tolerance reveals that PROTEIN L-ISOASPARTYL METHYLTRANSFERASE (PIMT), an enzyme that repairs abnormal isoaspartyl (isoAsp) residues in proteins, acts as a key player that governs seed desiccation tolerance to orthodox seeds but is ineffective in recalcitrant seeds. We observe that, unlike the orthodox seed of Oryza sativa, desiccation intolerance of the recalcitrant seeds of Oryza coarctata are linked to reduced PIMT activity and increased isoAsp accumulation due to the lack of coordinated action of ABA and ABI transcription factors to upregulate PIMT during maturation. We show that suppression of PIMT reduces, and its overexpression increases, seed desiccation tolerance and seed longevity in O. sativa. Our analyses further reveal that the ABI transcription factors undergo isoAsp formation that affect their functional competence; however, PIMT interacts with and repairs isoAsp residues and facilitates their functions. Our results thus illustrate a new insight into the mechanisms of acquisition of seed desiccation tolerance and longevity by ABI transcription factors and the PIMT module.
What morphological MRI features enable differentiation of low-grade from high-grade soft tissue sarcoma?
Authors: Boudabbous Sana , Hamard Marion , Saiji Essia , Gorican Karel , Poletti Pierre-Alexandre , Becker Minerva , Neroladaki Angeliki 
Published: June 2022

Objective: To assess the diagnostic performance of morphological MRI features separately and in combination for distinguishing low- from high-grade soft tissue sarcoma (STS). Methods and materials: We retrospectively analysed pre-treatment MRI examinations with T1, T2 with and without fat suppression (FS) and contrast-enhanced T1 obtained in 64 patients with STS categorized histologically as low (n = 21) versus high grade (n = 43). Two musculoskeletal radiologists blinded to histology evaluated MRI features. Diagnostic performance was calculated for each reader and for MRI features showing significant association with histology (p < 0.05). Logistic regression analysis was performed to develop a diagnostic model to identify high-grade STS. Results: Among all evaluated MRI features, only six features had adequate interobserver reproducibility (kappa>0.5). Multivariate logistic regression analysis revealed a significant association with tumour grade for lesion heterogeneity on FS images, intratumoural enhancement≥51% of tumour volume and peritumoural enhancement for both readers (p < 0.05). For both readers, the presence of each of the three features yielded odds ratios for high grade versus low grade from 4.4 to 9.1 (p < 0.05). The sum of the positive features for each reader independent of reader expertise yielded areas under the curve (AUCs) > 0.8. The presence of ≥2 positive features indicated a high risk for high-grade sarcoma, whereas ≤1 positive feature indicated a low-to-moderate risk Conclusion: A diagnostic MRI score based on tumour heterogeneity, intratumoural and peritumoural enhancement enables identification of lesions that are likely to be high-grade as opposed to low-grade STS. Advances in knowledge: Tumour heterogeneity in Fat Suppression sequence, intratumoural and peritumoural enhancement is identified as signs of high-grade sarcoma.
Hydrothermal carbonization as an alternative sanitation technology: process optimization and development of low-cost reactor
Authors: Chung Jae Wook , Gerner Gabriel , Ovsyannikova Ekaterina , Treichler Alexander , Baier Urs , Libra Judy , Krebs Rolf 
Published: June 2022

Background: The provision of safe sanitation services is essential for human well-being and environmental integrity, but it is often lacking in less developed communities with insufficient financial and technical resources. Hydrothermal carbonization (HTC) has been suggested as an alternative sanitation technology, producing value-added products from faecal waste. We evaluated the HTC technology for raw human waste treatment in terms of resource recovery. In addition, we constructed and tested a low-cost HTC reactor for its technical feasibility. Methods: Raw human faeces were hydrothermally treated in a mild severity range (≤ 200 °C and ≤ 1 hr). The total energy recovery was analysed from the energy input, higher heating value (HHV) of hydrochar and biomethane potential of process water. The nutrient contents were recovered through struvite precipitation employing process water and acid leachate from hydrochar ash. A bench-scale low-cost reactor (BLR) was developed using widely available materials and tested for human faeces treatment. Results: The hydrochar had HHVs (23.2 - 25.2 MJ/kg) comparable to bituminous coal. The calorific value of hydrochar accounted for more than 90% of the total energy recovery. Around 78% of phosphorus in feedstock was retained in hydrochar ash, while 15% was in process water. 72% of the initial phosphorus can be recovered as struvite when deficient Mg and NH4 are supplemented. The experiments with BLR showed stable operation for faecal waste treatment with an energy efficiency comparable to a commercial reactor system. Conclusions: This research presents a proof of concept for the hydrothermal treatment of faecal waste as an alternative sanitation technology, by providing a quantitative evaluation of the resource recovery of energy and nutrients. The experiments with the BLR demonstrate the technical feasibility of the low-cost reactor and support its further development on a larger scale to reach practical implementation.
Chromatin structure can introduce systematic biases in genome-wide analyses of Plasmodium falciparum
Authors: Baumgarten Sebastian , Bryant Jessica 
Published: June 2022

Background: The maintenance, regulation, and dynamics of heterochromatin in the human malaria parasite, Plasmodium falciparum, has drawn increasing attention due to its regulatory role in mutually exclusive virulence gene expression and the silencing of key developmental regulators. The advent of genome-wide analyses such as chromatin-immunoprecipitation followed by sequencing (ChIP-seq) has been instrumental in understanding chromatin composition; however, even in model organisms, ChIP-seq experiments are susceptible to intrinsic experimental biases arising from underlying chromatin structure. Methods: We performed a control ChIP-seq experiment, re-analyzed previously published ChIP-seq datasets and compared different analysis approaches to characterize biases of genome-wide analyses in P. falciparum. Results: We found that heterochromatic regions in input control samples used for ChIP-seq normalization are systematically underrepresented in regard to sequencing coverage across the P. falciparum genome. This underrepresentation, in combination with a non-specific or inefficient immunoprecipitation, can lead to the identification of false enrichment and peaks across these regions. We observed that such biases can also be seen at background levels in specific and efficient ChIP-seq experiments. We further report on how different read mapping approaches can also skew sequencing coverage within highly similar subtelomeric regions and virulence gene families. To ameliorate these issues, we discuss orthogonal methods that can be used to characterize bona fide chromatin-associated proteins. Conclusions: Our results highlight the impact of chromatin structure on genome-wide analyses in the parasite and the need for caution when characterizing chromatin-associated proteins and features.
High incidence of pulmonary tuberculosis in an indigenous Saharia tribe in Madhya Pradesh, central India—A prospective cohort study
Authors: Bhat Jyothi , Yadav Rajiv , Sharma Ravendra K. , Muniyandi Malaisamy , Rao V. G. 
Published: June 2022

Background
Lack of TB incidence data is an important evidence gap among Saharia–a high TB burden indigenous community in Madhya Pradesh, central India. The present study was undertaken to calculate the incidence of pulmonary tuberculosis in this tribe.

Objective
To calculate the incidence of pulmonary tuberculosis (PTB) among the Saharia tribal population in Madhya Pradesh, central India.

Methods
A prospective cohort study was conducted among the Saharia tribal population (aged 15 years and above) of Shivpuri district in Madhya Pradesh state in central India. A total of 9,756 individuals were screened for TB in the baseline TB prevalence survey during 2012–13. All available household members were screened for symptoms suggestive of pulmonary TB (presumptive TB). Two sputum specimens were collected from persons having symptoms suggestive of TB and examined by smear and culture tests. A cohort of all non-TB individuals in the baseline survey was followed-up for one year and re-screened for the sysmptoms of PTB in the year 2014–15. Based on the data collected, the incidence of TB over one year period was estimated per 100,000 population.

Results
A total of 9756 and 9044 individuals (≥ 15 years) were screened for symptoms suggestive of PTB during baseline and endline surveys respectively. The sputum specimens of presumptive TB cases were collected and examined by smear and culture tests. The overall incidence of bacteriologically positive (smear and/or culture) PTB over one year period was 1504 (95% Confidence Interval (CI): 1273–1776) per 100,000 in the study population, the incidence of smear-positive PTB was 1106 (95% CI: 910–1343), and the incidence of culture-positive PTB was 1084 (95% CI: 890–1319) per 100,000 population. The incidence for both smear and culture-positive PTB was 686 (95% CI: 535–878) per 100,000 population in the year 2014–15. The incidence of PTB was 2.8 times higher in males compared to females (2259 vs 807 per 100,000) and was positively correlated with age.

Conclusion
The findings of the study, the first of its kind in the Saharia tribal population, indicate a high incidence of TB in this tribal community thereby highlighting the urgent need for focused and intensified efforts to achieve the goal of TB elimination in the country.
Use of benzodiazepines is the risk factor for infection in patients aged 80 years or older with diffuse large B-cell lymphoma: A single-institution retrospective study
Authors: Ogiso Anna , Mizuno Tomohiro , Ito Kaori , Mizokami Fumihiro , Tomita Akihiro , Yamada Shigeki 
Published: June 2022

Background
The number of patients aged 80 years or older with diffuse large B-cell lymphoma (DLBCL) is increasing, and the incidence rate of the disease in this population group reaches up to 20%. The risk of infection is higher in older patients than in other patients. Although hypnotic drugs are frequently detected as potentially inappropriate medications, it is unclear whether hypnotic drugs affect the occurrence of infection during chemotherapy. Here, we investigated whether the use of hypnotic drugs is associated with infection during first-line chemotherapy in patients with diffuse large B-cell lymphoma (DLBCL) aged 80 years or older.

Methods
Japanese patients aged 80 years or older with diffuse large B-cell lymphoma who had received first-line chemotherapy at Fujita Health University Hospital from January 2005 to March 2020 were enrolled in this retrospective cohort study. The primary study outcome was the identification of the risk factor for infection during first-line chemotherapy.

Results
This study included 65 patients received first-line chemotherapy. The proportion of patients with National Comprehensive Cancer Network-international prognostic index ≥ 6 was higher in the infection group than in the non-infection group. The relative dose intensity of each anticancer drug (cyclophosphamide, adriamycin, and vincristine) and dose of prednisolone did not significantly differ between the two groups. Multivariate analysis showed that the use of benzodiazepines was a risk factor for infection (odds ratio, 4.131 [95% confidence interval: 1.225–13.94], P = 0.022).

Conclusion
DLBCL patients using benzodiazepines should be monitored for infection symptoms during chemotherapy.
The impact of community-based non-pharmacological interventions on cardiovascular and kidney disease outcomes in remote dwelling Indigenous communities: A scoping review protocol
Authors: Okpechi Ikechi G. , Hariramani Vinash Kumar , Sultana Naima , Ghimire Anukul , Zaidi Deenaz , Muneer Shezel , Tinwala Mohammed M. , Ye Feng , Sebastianski Megan , Abdulrahman Abdullah , Braam Branko , Jindal Kailash , Khan Maryam , Klarenbach Scott , Shojai Soroush , Thompson Stephanie , Bello Aminu K. 
Published: June 2022

IntroductionIndigenous people represent approximately 5% of the world’s population. However, they often have a disproportionately higher burden of cardiovascular disease (CVD) risk and chronic kidney disease (CKD) than their equivalent general population. Several non-pharmacological interventions (e.g., educational) have been used to reduce CVD and kidney disease risk factors in Indigenous groups. The aim of this paper is to describe the protocol for a scoping review that will assess the impact of non-pharmacological interventions carried out in Indigenous and remote dwelling populations to reduce CVD risk factors and CKD.Materials and methodsThis scoping review will be guided by the methodological framework for conducting scoping studies developed by Arksey and O’Malley. Both empirical (Medline, Embase, Cochrane Library, CINAHL, ISI Web of Science and PsycINFO) and grey literature references will be assessed if they focused on interventions targeted at reducing CVD or CKD among Indigenous groups. Two reviewers will independently screen references in consecutive stages of title/abstract screening and then full-text screening. Impact of interventions used will be assessed using the reach, effectiveness, adoption, implementation, maintenance (RE-AIM) framework. A descriptive overview, tabular summaries, and content analysis will be carried out on the extracted data.Ethics and disseminationThis review will collect and analyse evidence on the impact of interventions of research carried out to reduce CVD and CKD among Indigenous populations. Such evidence will be disseminated using traditional approaches that includes open-access peer-reviewed publication, scientific presentations, and a report. Also, we will disseminate our findings to the government and Indigenous leaders. Ethical approval will not be required for this scoping review as the data used will be extracted from already published studies with publicly accessible data.