bluuebunny/crossref_metadata_2025_split huggingface dataset:
The high incidence and risk factors of levetiracetam and lacosamide-related skin rashes in glioma patients
Authors: Onodera Mikoto , Saito Taiichi , Fukui Atsushi , Nitta Masayuki , Tsuzuki Shunsuke , Koriyama Shunichi , Masamune Ken , Kawamata Takakazu , Muragaki Yoshihiro 
Published: June 2022

Abstract
Antiseizure drug (ASD)-induced skin rash remains the main side effect of seizure management in patients with glioma. New generations of ASDs, such as levetiracetam (LEV) and lacosamide (LCM) are associated with less frequent skin rashes than conventional ASDs. However, there are few reports regarding the incidence of skin rashes by LEV and LCM in patients with glioma. Therefore, the aim of this study was to investigate the incidence and risk factors of LEV- and LCM-associated skin rashes in patients with glioma. We compared the incidence of ASD-associated skin rash between 353 patients with glioma and 125 patients with meningioma, who received LEV or LCM and underwent surgery between 2017 and 2019 at our institution. Furthermore, to evaluate the association between potential risk factors and ASD-associated skin rashes, univariate and multivariate analyses were performed. The incidence of ASD-associated skin rash in patients with glioma was higher (11%) than in those with meningiomas (1.6%). The multivariate regression analysis showed that adjuvant treatment with radiotherapy (p = 0.023) and a history of drug allergy (p = 0.023) were significant risk factors for ASD-associated skin rash. The rate of ASD-related skin rashes in patients with glioma was also higher than the previously reported rates of 1-3% in patients with epilepsy. Our results indicate that adjuvant treatment with radiotherapy and a history of drug allergy correlated with a high incidence of ASD-related skin rashes in patients with patients who receive LEV and LCM. Patients with these two factors should be carefully checked for skin rashes.
Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-induced Thermal Stability to the Serotonin 1A Receptor
Authors: Sarkar Parijat , Bhat Akrati , Chattopadhyay Amitabha 
Published: June 2022

Abstract
G protein-coupled receptors (GPCRs) constitute the largest class of membrane proteins that transduce signals across the plasma membrane and orchestrate a multitude of physiological processes within cells. The serotonin1A receptor is a crucial neurotransmitter receptor in the GPCR family involved in a multitude of neurological, behavioral and cognitive functions. We have previously shown, using a combination of experimental and simulation approaches, that membrane cholesterol acts as a key regulator of organization, dynamics, signaling and endocytosis of the serotonin1A receptor. In addition, we showed that membrane cholesterol stabilizes the serotonin1A receptor against thermal deactivation. In the present work, we explored the molecular basis of cholesterol-induced thermal stability of the serotonin1A receptor. For this, we explored the possible role of the K101 residue in a cholesterol recognition/interaction amino acid consensus (CRAC) motif in transmembrane helix 2 in conferring the thermal stability of the serotonin1A receptor. Our results show that a mutation in the K101 residue leads to loss in thermal stability of the serotonin1A receptor imparted by cholesterol, independent of membrane cholesterol content. We envision that our results could have potential implications in structural biological advancements of GPCRs and design of thermally-stabilized receptors for drug development.
Understanding the ups and downs, application of hydrologic restoration measures for a large Subtropical Lake.
Authors: Julian Paul , Welch Zach 
Published: June 2022

Abstract
Hydrologic regimes in shallow lakes have a strong influence on the ecology and function of the system, and changes in water levels can have nonlinear disproportionate effects in these low gradient systems. When water levels are high, upper elevation littoral areas are impacted by flooding effects, benthic habitats are degraded, and nutrients are redistributed throughout the lake. When water levels are low, wetland littoral areas are dried out, prompting shifts in plant communities. Lake Okeechobee, a large shallow lake, is a diverse and complex ecosystem managed for multiple purposes. Currently, water levels within the lake are managed based on the Lake Okeechobee Regulation Schedule of 2008, which is being replaced due to the completion of key restoration projects. The new regulation schedule, Lake Okeechobee System Operating Manual (LOSOM), updates water management rules while providing the needed balance of water to downstream systems. The objective of this study is to evaluate LOSOM relative to ecologically significant performance measures. Overall, the proposed regulation schedule is expected to have deeper average lake levels, increasing the occurrence of damaging high stage events and reducing the frequency of low stage events. While decreases in the severity and frequency of low stage events will be beneficial, increases in high stage conditions may impact the long-term ecology of the system. As lake management shifts to optimize restoration efforts around and downstream of Lake Okeechobee, restoration projects upstream of the lake become critical to building and improving resilience in this central South Florida ecosystem.
Arsenic Pollution and Human Health Risk Assessment in the Region of Racha-Lechkhumi and Kvemo Svaneti of Georgia
Authors: Tebidze Vakhtang , Zurabishvili Elene , Tatanashvili Giorgi , Varazi Tamar , Bunin Evgeni , Bakradze Elina 
Published: June 2022

Abstract
The region of Racha-Lechkhumi and Kvemo Svaneti is the main source of Arsenic pollution in Georgia where there are several abandoned arsenic production factories that have been discontinued since late 80s. However, the past production waste still enters the river through the water coming out of an abandoned field and causes significant contamination of soils and waters of adjacent areas. This poses a major risk of chronic environmental exposure and intoxication among the population living in these areas.
The expedition was conducted in this region for sampling activities of soils and waters to evaluate level of Arsenic pollution and subsequent risks of contamination of the food chain with Arsenic. Then the population survey was conducted to collect data on incidence of the health problems associated with chronic arsenic intoxication in population living in the polluted areas.
Soil samples analysis showed that there was significantly high level of Arsenic pollution in the studied areas and there could be a risk of contamination of the food chain with Arsenic. Most reported health problems were hypertension, impaired vision, memory impairment, swelling of the limbs, chronic kidney diseases, fatigue / general weakness, insomnia, polyneuropathy and frequent dizziness.
The health problems reported by the population of this region can be related to the chronic arsenic exposure and intoxication. Further laboratory investigations are needed to determine levels of arsenic exposure among inhabitants.
The possibility of predicting eﬀectiveness oftherapy in patients with new inﬁltrative pulmonary tuberculosis by baseline activity of adenosine deaminase and inﬂammatory response parameters
Authors: Dyakova M. E. , Аlekseeva N. P. , Esmedlyaeva D. S. , Yablonskiy P. K. 
Published: June 2022

The objective: to evaluate the possibility of using the baseline activity of adenosine deaminase (ADA) to predict eﬀectiveness of therapy in patients with new inﬁltrative pulmonary tuberculosis (IPTB).Subjects and Methods. Data of 121 patients with new inﬁltrative pulmonary tuberculosis were analyzed; patients were divided into groups according to therapy eﬀectiveness.Results., The discriminant analysis of data of new inﬁltrative pulmonary tuberculosis patients made it possible to obtain adiscriminant function which included the activity of ADA, the concentration of haptoglobin (HP) and ceruloplasmin (CP) – parameters reﬂecting that severity of the disease and protective potential of the host.Conclusion. Analysis of ADA activity in combination with level of HP and CP allows the following: predicting eﬀectiveness of the intensive phase of therapy before it begins in patients with new inﬁltrative pulmonary tuberculosis (with the accuracy of 77.0%); assuming that the reduction of ADA activity and inhibition of the inﬂammatory response may be useful for treatment of patients with new inﬁltrative pulmonary tuberculosis.
Eﬃcacy of using bedaquiline in treatment of tuberculosis patients with multiple and extensive drug resistance
Authors: Starshinova A. A. , Nazarenko M. M. , Belyaeva E. N. , Kudlay D. A. , Pavlova M. V. , Yablonskiy P. K. 
Published: June 2022

The objective: to compare treatment eﬃcacy of pulmonary tuberculosis patients with multiple (MDR) and extensive drug resistance (XDR) using a standard chemotherapy regimen and the regimen containing bedaquiline.Subjects and Methods. A retrospective study was conducted to analyze treatment outcomes in 219 patients with pulmonary tuberculosis and MDR/XDR of Mycobacterium tuberculosis (MTB) aged 18-75 years old who were treated in in-patient and out-patient facilities of St. Petersburg from 2016 to 2019. Treatment outcomes were analyzed by subgroups formed taking into account resistance patterns and addition of bedaquiline to the treatment regimens: Ia – n = 94 (MDR TB; Bq-) and IIa ‒ n = 80 (XDR TB; Bq-); Ib ‒ n = 22 (MDR TB; Bq+) and IIb ‒ n = 23 (XDR TB; Bq+). Clinical and laboratory parameters of patients, the severity of comorbidity were assessed before the start of treatment, after 3, 6, 12-14 and 18-24 months of therapy, as well as after therapy completion and during the follow-up period. Statistical analysis was carried out using Statistica 10.0 and methods of parametric and nonparametric statistics and the SPSS 16.0 software, where p ≤ 0.05 was considered signiﬁcant.Results. XDR TB patients in Subgroup IIb were signiﬁcantly more likely to have a high level of comorbidity according to Charlson index (from 5 to 6 points) – in 34.7% of cases versus 5.0% in Subgroup IIa. At all stages of treatment in MDR TB patients with Bq+ (Ib), sputum conversion was recorded signiﬁcantly more often versus patients of Subgroup Ia with Bq- when examined at all stages, with maximum eﬀectiveness achieved by 18-24 months of treatment (90.9%). Treatment eﬃcacy of XDR TB patients (IIb, Bq+) was also signiﬁcantly higher versus treatment regimen containing no bedaquiline (60.8% (IIb, Bq+) versus 25.0% (IIa, Bq-), χ2 = 4.61, p < 0.05).Conclusions. Achieved high eﬃcacy of therapy in Subgroups Ib and IIb containing Bq provided a positive impact on treatment default rates, that were recorded in a low percentage of cases in those subgroups. An ineﬀective course of treatment in MDR TB patients treated with regimens containing no Bq was observed in 42.5% in Subgroup Ia, while this rate made only 0.09% in Subgroup Ib. Treatment eﬀectiveness was the highest in XDR TB patients of Subgroup IIb when Bq was added to the treatment regimen.
Response of runoff and nitrogen loadings to climate and land use changes in the middle Fenhe River basin in Northern China
Authors: Zhu Xueping , Chang Ke , Cai Wenjun , Zhang Aoran , Yue Guangtao , Zhao Xuehua 
Published: June 2022

Abstract
Investigating and understanding the responses of runoff and nitrogen loading to climate and land use change is particularly important for future water resources management. In this article, the Soil and Water Assessment Tool (SWAT) was used to simulate runoff and nitrogen loading in the middle reaches of the Fenhe River. The model was calibrated by the SWAT calibration and uncertainty procedure (SWAT-CUP) to achieve the accuracy of simulating runoff and nitrogen loadings. Furthermore, 20 climate change scenarios and seven extreme land use change scenarios were set up and run on the calibrated model. The results showed that runoff and nitrogen loading decreased when temperature increased and increased with increasing precipitation. Runoff was more sensitive to changes in precipitation (±10%) than temperature (±2 °C), while nitrogen loading showed the opposite pattern. When the two climatic factors changed in the same direction, the combined effect was larger than either factor alone, whereas the change in the opposite direction produced a weaker effect. The changes produced by different extreme land use scenarios on runoff and nitrogen loading were significantly different and were more obvious during the flood season than in the non-flood season. The results of this study provide a useful guide for water resource managers.
Assistive Robots for Patients With Amyotrophic Lateral Sclerosis: Exploratory Task-Based Evaluation Study With an Early-Stage Demonstrator
Authors: Klebbe Robert , Scherzinger Stefan , Eicher Cornelia 
Published: June 2022

Background
Although robotic manipulators have great potential in promoting motor independence of people with motor impairments, only few systems are currently commercially available. In addition to technical, economic, and normative barriers, a key challenge for their distribution is the current lack of evidence regarding their usefulness, acceptance, and user-specific requirements.

Objective
Against this background, a semiautonomous robot system was developed in the research and development project, robot-assisted services for individual and resource-oriented intensive and palliative care of people with amyotrophic lateral sclerosis (ROBINA), to support people with amyotrophic lateral sclerosis (ALS) in various everyday activities.

Methods
The developed early-stage demonstrator was evaluated in a task-based laboratory study of 11 patients with ALS. On the basis of a multimethod design consisting of standardized questionnaires, open-ended questions, and observation protocols, participants were asked about its relevance to everyday life, usability, and design requirements.

Results
Most participants considered the system to provide relevant support within the test scenarios and for their everyday life. On the basis of the System Usability Scale, the overall usability of the robot-assisted services for individual and resource-oriented intensive and palliative care of people with ALS system was rated as excellent, with a median of 90 (IQR 75-95) points. Moreover, 3 central areas of requirements for the development of semiautonomous robotic manipulators were identified and discussed: requirements for semiautonomous human-robot collaboration, requirements for user interfaces, and requirements for the adaptation of robotic capabilities regarding everyday life.

Conclusions
Robotic manipulators can contribute to increase the autonomy of people with ALS. A key issue for future studies is how the existing ability level and the required robotic capabilities can be balanced to ensure both high user satisfaction and effective and efficient task performance.
Bibliometric approach for innovations analysis in the field of Disaster Risk Reduction
Authors: Widuri Noorika Retno , Sulaksana Nana , Zakaria Zufialdi , Rachmawati Rulina , Tupan Tupan , Yoganingrum Ambar 
Published: June 2022

ABSTRACT

Introduction. This study demonstrates the use of bibliometric methods for innovation analysis, using the field of Disaster Risk Reduction (DRR) in Indonesia as a case study. The scientific contribution of this paper is to show the advantages and disadvantages of bibliometrics compared to other methods for analyzing innovations in the field of disaster management.
Data Collection Methods. This research used journal articles in the field of DRR taken using the keyword of Disaster Risk Reduction and Indonesia from Scopus published in 2008-2020
Data Analysis. This paper applies a co-occurrence analysis of keywords, institutions and authors to show the emerging innovations as well as institutions and authors involved in DRR innovations development in Indonesia
Results and Discussion. The result showed that bibliometrics is an approach that can be used to analyze emerging innovations in research related to DRR in Indonesia. In addition, this approach has a number of advantages compared to the discussion and SLR methods, including the ability to display the period of emergence of the innovations and the interaction network between innovations to predict innovations that will become trends in the future.
Memaksimalkan peran perpustakaan sebagai sumber belajar di Sekolah Menengah Atas Muhammadiyah 1 Ponorogo
Authors: Nurhayati Anna , Riyanto Riyanto , Rif’an Moh. 
Published: June 2022

Introduction. This research analyses efforts made by the library of Muhammadiyah Senior High School 1 Ponorogo in maximising the role of library as a source of learning as issued by the International Federation of Library Associations and Institution.
Data Collection Methods. This paper employed a qualitative descriptive approach through participant observations and structured interviews.
Data analysis. Data from interview transcripts, observation sheets and documentations were analysed by conducting the process of data display, data reduction and conclusion drawing. The analysis process also considered several supporting literature in the form of books, scientific journals, conference proceeding.
Results and discussion. The roles of the library as a learning source are demonstrated by several activities to improve users’ skills such as providing resource capabilities and supporting critical thinking, literacy, and personal and interpersonal development.
Conclusion and suggestions: In serving its responsibility as a learning resource, the library at SMA Muhammadiyah 1 Ponorogo did not fully comply with the International Federation of Library Associations and Institutions' standard requirements. Libraries are limited in their ability to fulfill information needs, but they have make little effort to explain that information to users.
Tinjauan literatur argumentatif tentang kepemilikan data arsip digital non-fungible token (NFT) pada teknologi blockchain
Authors: Fachmi Achmad , Mayesti Nina 
Published: June 2022

Introduction. NFT scheme is used to certify the authenticity of digital records. It is also to provide a code for the original (genuine) data recorded on the blockchain. NFT creates a single data that cannot be duplicated in digital records. The misuse of NFT authentication to illegally certify other people's data have become a problem.
Data Collection Methods. This study used an argumentative literature review with a qualitative approach. It used literature data sources from various fields related to the basic concepts of archival science as a basic analysis.
Data Analysis. The analysis process consisted of several stages, namely reading the reviewed literature, summarising, analysing, and synthesising them critically and deeply.
Results and Discussion. The concept of development related to data ownership issues can be formulated by collaborating with user communities, developers, and digital service designers (ecosystems). As a preventive measure, understanding the logistical consequences of data security threats was very helpful. This included authenticity, integrity, confidentiality, and authorisation, they served as important points to reduce risk.
Conclusion. The NFT concept continues to develop dynamically. A more in-depth study and the involvement of archival science are necessary, thus, NFT scheme can build trust in digital records regarding the issue of data ownership.
Patrones de actividad circadiana y lunar del jaguar y el puma en relación con sus presas y competidoras (Carnivora: Felidae)
Authors: Mooring Michael S. , Eppert Amy A. 
Published: June 2022

Introducción: Los cambios temporales de nicho pueden amoldar las interacciones predador-presa al permitir a la presa evadir los predadores, mejorar la eficacia de la alimentación y reducir la competición entre predadores. Además de los patrones de actividad circadianos, el ciclo lunar mensual puede influye en los patrones de actividad nocturna de los mamíferos. Objetivo: Mediante muestreos con cámaras trampa en sitios de la pendiente del Pacífico y la Cordillera de Talamanca, investigamos los patrones de actividad circadiana (día y noche) y nocturna durante las fases de la luna del jaguar (Panthera onca) y puma (Puma concolor). Métodos: Investigamos la superposición y segregación temporal entre pares de cada predador y sus presas primarias, y entre sus competidores utilizando análisis de superposición, estadísticas circulares y abundancia relativa, teniendo en cuenta diferencias de hábitat, estaciones, y de impacto humano entre los sitios. Resultados: Nuestros resultados respaldaron la existencia de una separación temporal de nicho entre las dos especies de predadores, aunque ambos fueron clasificados como catemerales, el jaguar era principalmente diurno, mientras que el puma era principalmente nocturno. Descubrimos que el jaguar y el puma practican distintos patrones de actividad nocturna durante las fases de la luna, con el jaguar exhibiendo un aumento dramático en la actividad durante la luna llena y el puma manteniendo un nivel de actividad más consistente a través de las fases lunares. Sin embargo, durante la luna llena, ambas especies fueron más activas durante la noche y menos activas durante el día, lo que sugiere que practican un cambio de nicho temporal para aprovechar las actividades de caza durante la iluminación lunar más brillante de cada mes. Discutimos las presas primarias predichas y las especies competidoras. Conclusión: Concluimos que el jaguar y el puma exhiben una separación de nicho significativa en actividad circadiana y lunar. A través de estos distintos patrones de actividad temporal, el jaguar y el puma pueden explotar una base de presas ligeramente diferente a pesar de su tamaño similar.
Prescrições colonizadoras e sobrevoos possíveis sobre o currículo de história
Authors: Silva Guilherme Henrique da , Lucini Marizete 
Published: June 2022

O presente artigo objetiva apresentar reflexões no âmbito do Ensino de História em diálogo com cenários vivenciados no exercício da docência, na disciplina de História, em uma escola pública do estado de São Paulo, no contexto da pandemia provocada pelo SARS-CoV-2, na modalidade do ensino remoto. Para tanto, nos ancoramos em relatos coletados durante as aulas ministradas e estudos bibliográficos, no campo dos estudos de currículo e do ensino de História. Esta prática docente possibilitou problematizações entre o conteúdo ofertado em consonância com as diretrizes oficiais e seus desdobramentos entre os estudantes. Diante da relação entre o currículo oficial e os estudantes surgiu a questão central deste trabalho: discutir o lugar do Outro e da Diferença no currículo paulista durante a pandemia. Ao final, tais implicações nos direcionam a pensar que uma educação problematizadora produz alterações tanto na práxis docente, quanto no perfil dos estudantes, refletindo em uma sociedade democrática.
Robot Hearing Through Optical Channel in a Cocktail Party Environment
Authors: Guo Xiao , Ding Siyi , Peng Ti , Li Kenan , Hong Xiaoping 
Published: June 2022

The cocktail party problem refers to a challenging process when the
human sensory system tries to separate a specific voice from a loud
mixture of background sound sources. The problem is much more demanding
for machines and has become the holy grail in robotic hearing. Despite
the many advances in noise suppression, the intrinsic information from
the contaminated acoustic channel remains difficult to recover. Here we
show a simple-yet-powerful laser-assisted audio system termed REAL
(Robot Ear Accomplished by Laser) to probe the vibrations of
sound-carrying surfaces (mask, throat and other nearby surfaces) in
optical channel, which is intrinsically immune to acoustic background
noises. Our results demonstrate that REAL can directly obtain the
audio-frequency content from the laser without acoustic channel
interference. The signals can be further transcribed into
human-recognizable audio by exploiting the internal time and frequency
correlations through memory-enabled neural networks. The REAL system
would enable a new way in human-robot interaction.

Xiaoping Hong Email: hongxp@sustech.edu.cn