bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyethylene Terephthalate (PET) Biodegradation by Pleurotus ostreatus and Pleurotus pulmonarius
Authors: Odigbo Chioma , Adenipekun Clementina , Oladosu Ibrahim , Ogunjobi Adeniyi 
Published: September 2022

Abstract

Essential properties of Polyethylene terephthalate (PET) such as lightness, high transparency, high mechanical strength, good moisture barrier, high heat resistance, and relatively low cost make it a suitable material for the packaging of natural mineral and soft drink bottles. However, these have contributed significantly to household and municipal waste responsible for the growing environmental pollution that has become a threat to the planet. Low-cost, ecologically friendly treatments with the capacity to eradicate plastics, are being advocated for by scientists. This s, therefore, seeks to explore the potential capacity of Pleurotus ostreatus and Pleurotus pulmonarius in biodegrading PET plastic on two different substrates (Soil and rice straw). The substrates were contaminated with 5% and 10% plastic prior to inoculation with Pleurotus ostreatus and Pleurotus pulmonarius separately and left to incubate for 2 months. Chemical changes in the plastic were monitored using FT-IR and GC-MS. FTIR spectral analysis of PET flakes displayed different shifts in the wavenumbers, changes in band intensity, and the formation of new peaks, indicating changes in functional groups. Degradation products like hydrocarbons, carboxylic acids, alcohols, esters, and ketones were detected in the GC-MS analysis of the decomposed PET plastic.
Ternary Composite Electrode Carbon Fiber/mno2 /polyaniline for Supercapacitor Applications Based on Naturally Available Broom and Bamboo Sticks
Authors: Shetty Yashaswini , Holla Sowmya R , N Sangeetha D , M Selvakumar 
Published: September 2022

Abstract
In the present study, energy harvesting is done from carbon
fibers (CFs) synthesized using a naturally available
broomstick and bamboo stick. The broom and bamboo sticks have been
reprocessed in an alkaline solution using a controlled hydrothermal
method. The carbonization of the cellulose fibers resulted in the
production of CFs. The synthesized CFs have been used to prepare a
ternary composite electrode with MnO2 and polyaniline
(PA). Thus, prepared ternary composite electrodes were
used for the supercapacitor application. The Supercapacitor with a
maximum specific capacitance (SC) of 373 F/g (from
Broomstick) and 132 F/g (from the bamboo stick) was fabricated,
which showed good cycling stability. The structural properties of
the electrode materials were confirmed using X-ray diffraction,
scanning electron microscopy, EDAX, BET adsorption-desorption
experiment, and Fourier transform infrared spectroscopy techniques.
The fabricated symmetrical electrode's supercapacitor properties
were analyzed using cyclic voltammetry (CV),
electrochemical impedance, and galvanostatic charge-discharge
(GCD) cycling technique.
Social Return on Investment (SROI) Project of the Surgical Waiting List Management System
Authors: Muñoz José Luis González , Ruiz Antonio J. García 
Published: September 2022

Abstract
Background
In Andalusia, the right to maximum waiting times for health care clashes with the available supply, leading to an increase in demand in the form of waiting lists. To cope with this situation, the activity of private centers has been created for certain diagnostic tests or surgical activities. Management, therefore, depends on these contracted private centers, which have to evaluate their offers in economic and healthcare terms, to be able to obtain the healthcare agreements. There are different methods of economic evaluation, based mainly on the economic and care aspects. The model based on social return on investment (SROI) allows us to evaluate an action both from the economic side and from the side of all the actors involved. However, there are no studies on the suitability of waiting lists using this model.
Methods
A cross-sectional and prospective design was carried out between April 2021 and March 2022. After meeting the inclusion criteria, 75 patients were surveyed in person to determine their gained quality of life and their social assessment, to analyze the social return on investment, and to determine the suitability of the intervention (concerted diagnostic endoscopy activity in a concerted center) from the point of view of the different stakeholders involved.
Discussion
In this first approach, the study protocol is presented. Subsequently, the economic, social, and environmental settings of the intervention of concerted activity to adjust endoscopy diagnostic waiting list times will be known. Also, the economic cost of the interventions of the health concerts and the Andalusian public health system about the intervention, the cost of the increase in extraordinary health resources, determine the most prevalent surgeries from highest to lowest and specify the highest number of surgeries that are established in the concerts and the Andalusian Public Health Service.
Trial registration: 113.21 [Registry ID: CÁDIZ RESEARCH ETHICS COMMITTEE
The influence of verapamil on the pharmacokinetics of the pan-HER tyrosine kinase inhibitor neratinib in rats: the role of P-glycoprotein-mediated efflux
Authors: Qi Defei , Dou Yuanyuan , Zhang Wenke , Wang Mengqing , Li Yingying , Zhang Mingzhu , Qin Jia , Cao Jinlan , Fang Dong , Ma Jing , Yang Wei , Xie Songqiang , Sun Hua 
Published: September 2022

Abstract
Neratinib, an irreversible pan-HER tyrosine kinase inhibitor, has been approved for the treatment of HER2-positive (HER2+) early-stage and brain metastatic breast cancer. Thus far, the pharmacology effects and pharmacodynamics of neratinib have been well studied. However, the disposition of neratinib and its influencing factors in vivo remain unclear. P-glycoprotein (P-gp), one of the most extensively studied transporters, substantially restricts penetration of drugs into the body or deeper compartments (i.e., blood-brain barrier, BBB), regarding drug resistance and drug-drug interactions. Thereby, the aim of this study was to investigate the influence of verapamil (a P-gp inhibitor) on the pharmacokinetics of neratinib in rats. Here, we have established a high specific, selective and sensitive ultra-performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) method to quantify plasma concentrations of neratinib in rats. Pharmacokinetic results showed that verapamil significantly increased the system exposure of neratinib, as Cmax increased by 2.09-fold and AUC0 − t increased by 1.64-fold, respectively. Additionally, the in vitro transport of neratinib using Madin-Darby canine kidney II (MDCK II) and MDCK-MDR1 cell line models. As a result, the net flux ratio was over than 2 and decreased over 50% by verapamil, suggesting that probably neratinib was a substrate of P-gp. Hence, coadministration of P-gp inhibitors might be indispensable for neratinib in the treatment of breast cancer patients, especially for brain metastases. These findings may support the further clinical development and application of neratinib.
Experimental study on Alkali Activated Fine Aggregate in mortar and Masonry Blocks
Authors: MP Naveena , Narayana G , . Radhakrishna 
Published: September 2022

Abstract
The present study focused on development of Alkali Activated Fine Aggregate (AAFA) by palletization method. AAFA were manufactured using Ground Granulated Blast Furnace Slag (GGBS) and alkali activator solution at ambient conditions. Sodium hydroxide of six molarity and sodium silicate to sodium hydroxide ratio of 2.5 was used. The alkali activated fine aggregates were prepared using a drum mixer by maintaining a certain rotation angle and speed. AAFA processed a rough texture. The flow properties of the plastering mortar (1:3) were studied by replacing sand by Alkali activated fine aggregate. Mortar cubes were tested to determine the characteristics of alkali activated fine aggregate mortar. Compressive strength and modulus of elasticity of the mortar were evaluated at the age of 28 days. Results indicate that speed of the mixer influence the properties of alkali activated fine aggregate. AAFA exhibited lower specific gravity, high water absorption, and lesser bulk density compared to manufactured sand. The flow of mortar increases by increasing the percentage of Alkali Activated Fine Aggregate, up to a 60% replacement of M-sand for a water cement ratio of 1.3. Beyond 60% replacement, there is a bleeding in the mix. The compressive strength of Alkali activated Fine aggregate mortar gives consistently optimum compressive strength up to an 80% replacement of AAS by M-sand. The manufactured aggregates were found to be suitable in making plaster/masonry mortar and for making masonry units.
Effects of Structured Exercise Intervention on Fatigue, Quality of Life and Clinical Outcomes During Umbilical Cord Blood Transplantation in Children and Adolescents
Authors: Huang Lu , Wu Yun , Xu Ming , Wang Yingying , Jia Chengzhen , Song Guiqi , Song Kaidi , Wu Yaohua , Zhang Yongliang 
Published: September 2022

Abstract
Children and adolescents undergoing umbilical cord blood transplantation (UCBT) are faced with severe challenges and a decline in quality of life (QoL) during the inpatient period. This prospective study investigated the effect of structured exercise intervention on fatigue, QoL and clinical outcomes.Participants (n=48) were randomized to a control group (CG: usual care) or an intervention group (IG: structured exercise intervention). Fatigue and QoL were assessed at hospital admission, 14 days after UCBT, and at discharge using repeated measures analysis of variances. In addition, engraftment kinetics, supportive care, and transplant-related complications were derived from medical records. Forty-four patients completed the study, and the IG participated in an average of 2.12 (1.36-2.8) training sessions with a duration of 24 (16-34) min weekly. Fatigue increased at 14 days after UCBT (76.04±15.88 vs. 69.03±15.36, p=0.031), but it returned to pre-UCBT levels at discharge (74.10±16.31 vs. 76.04±15.88, p=0.578), with patients' QoL was positively maintained during the exercise intervention (75.16±11.27 vs. 74.77±10.58 vs. 77.40±14.33, p＞0.05). However, no significant differences were observed for the remainder of clinical outcomes (p＞0.05). In conclusion, our randomized study indicated that structured exercise intervention might exert a protective effect by attenuating the decline in fatigue and QoL.
Double Differential Ionization Cross-Sections of CF3Cl molecule by Electron Impact
Authors: Kumar Rajeev 
Published: September 2022

AbstractFor the first time, we evaluated partial and total, double differential ionization cross-sections (DDCS) of CF3Cl molecule by electron impact using a modified Jain-Khare semi-empirical approach. We have evaluated double differential ionization cross-section as a function of energy loss of primary electron /or secondary electron energy at fixed incident angles (300and 600) and at fixed incident electron energies i.e. 100, 200 and 500 eV. Angular variation of DDCS at fixed incident electron energies and fixed secondary electron energies have also been evaluated. No other data for double differential ionization cross-sections are available for comparison.
Investigation of Factors Associated with Retinal Oxidative Stress and Inflammation that affect the Foveal Avascular Zone in Healthy Eyes: An Optical Coherence Tomography Angiography Study
Authors: O'Shea Susan M. , O’Dwyer Veronica M. , Butler John S. , Scanlon Grainne 
Published: September 2022

Abstract
Purpose
The size and shape of the foveal avascular zone (FAZ) can change due to retinal diseases associated with oxidative stress and inflammation, such as diabetic retinopathy, glaucoma, hypertensive retinopathy and macular degeneration. Macular pigment (MP), a powerful retinal antioxidant, may confer protection. This study aims to assess the relationship, if any, between factors that may affect the superficial FAZ (i.e. blood pressure (BP), vessel density, perfusion, overweight/obesity), and possible links with MP optical density (MPOD), in young, healthy subjects.
Methods
One hundred and fifty-four subjects, aged 18 to 35 years, were recruited. The superficial FAZ area, foveal vascularity and central macular thickness (CMT) were assessed using the Cirrus 5000. Health parameters including, BP, body mass index (BMI), trunk fat % and MPOD were analyzed, to determine possible associations with the FAZ.
Results
Mean FAZ area was 0.23 ± 0.08mm2. FAZ area was positively correlated with BMI (Pearson’s r = 0.189, p = 0.03) and significantly larger in participants with lower MPOD, on bivariate analysis (p = 0.04). Significant correlates of FAZ area in the multivariate model included age, sex, BP, vessel perfusion central, CMT and trunk fat %, which collectively contributed 65.2% of the overall variability.
Conclusion
These findings suggest that reduced vessel perfusion, thinner CMT, higher trunk fat % and low MPOD are plausible predictors of a larger FAZ area, in healthy eyes. Non-invasive OCTA testing, in association with these predictors, may aid in the early detection and monitoring of retinal diseases associated with oxidative stress and inflammation.
Xanthones from Gentianopsispaludosa(Hook. f.) Ma ameliorates colonic epithelial-mesenchymal transition through regulating autophagy
Authors: Liu Na , Kou Liang , Liu Yuemin , Bo Shuangqin , jing Ming 
Published: September 2022

Abstract
Ethnopharmacological relevance: Ulcerative colitis (UC) is an immune-mediated, idiopathic, chronic, recurrent inflammatory bowel disease inflammatory bowel diseases (IBD). Gentianopsis paludosa (Hook. f.) Ma, a traditional Tibetan medicine, is commonly used to treat hepatitis, cholecystitis, diarrhea, gastroenteritis, conjunctivitis, scabies, swollen poison and other diseases. The research group replicated the ulcerative colitis (UC) rat model through (2,4-dinitrobenzenesulfonic acid, DNBS）in the early stage, and it was clear that xanthone is the main active components, but the mechanism is still unclear and needs to be further elucidated.
Aim of the study: Inflammatory bowel disease (IBD) is considered as one of the most intractable diseases worldwide. Intestinal fibrosis, as the most serious complication of IBD, can easily lead to intestinal scarring, intestinal stricture and even intestinal obstruction. Therefore, there is an urgent need to accelerate the development of anti-fibrotic drugs for IBD. The purpose of this study was to investigate the protective effect of xanthone from Gentianopsis paludosa (GPX) on the colonic epithelial-mesenchymal transition and its specific mechanism.
Methods: The damage to colonic epithelium was caused by intraperitoneally injecting DNBS, and the therapeutic potential of GPX on colonic fibrosis was detected, which was verified by macroscopic evaluation of rats (disease activity index, DAI;colonic mucosal damage index,CMDI), histopathological staining and Western blotting. In addition, the effect of GPX was tested on NCM460 cells in vitro. The expression levels of EMT-related proteins, mRNAs and autophagy-related proteins, mRNAs in colon epithelial cells were detected by immunofluorescence assay, western blotting, quantitative real-time PCR and other techniques, and the possible mechanisms were explored.
Result: GPX significantly inhibited colonic fibrosis, as preliminarily demonstrated by DNBS-induced body weight gain, DAI, CMDI score reduction and colonic fibrosis area reduction in rats. Moreover, GPX could down-regulate the expression of mesenchymal transition-related genes and proteins, and up-regulate the level of autophagy in colonocytes. Mechanistic studies showed that GPX could affect EMT by regulating autophagy, as evidenced by autophagy inhibitors (3-MA) or agonists (Rapa) that inhibit or enhance this effect of GPX.
Conclusion: Herein, the evidence was provided to support that GPX could effectively inhibit colonic fibrosis, and its mechanism of action may be related to the inhibition of epithelial-mesenchymal transition and the regulation of autophagy in intestinal epithelial cells.
Research on Fall Armyworm (Spodoptera frugiperda, J.E Smith): A bibliometric of scientific research (1980-2022)
Authors: Khanyile Lungelo , Simelane Victor B. , Masuku Landile 
Published: September 2022

Abstract
Fall armyworm (FAW) is a dangerous invasive insect belonging to the Spodoptera genus and it causes a lot of damage to most field crops which can lead to great yield losses. In this study, we analyzed a total of 2754 FAW publications retrieved from the Web of Science database. More than 95% of FAW-related publications were published using the English language. Articles formed 93,5% of the whole FAW-related documents. In the last decade, an increase in the number of publications was observed and the highest number of publications (320) was observed in 2021. FAW-related publications were mostly related to Entomology and Agricultural research areas. The top 5 journals contributing to FAW-related literature were Journal of Economic Entomology, The Florida Entomologist, Environmental Entomology, Pest Management Science, and Journal of Entomological Science, with 270, 218, 106, 75, and 75 publications, respectively. Wiseman BR has the greatest number of publications, 82, followed by Meagher RL and Williams WP with 80 and 68 publications, respectively. The top 5 institutions which contributed the most to FAW literature were the US Department of Agricultural Research Service, Agricultural Research Service, the University of Sao Paulo, the University of Florida, and Louisiana State University with 265, 97, 86, 85, and 83 publications, respectively. In terms of countries, only USA, Brazil, China, and Mexico published more than 200 documents. This study could be used as a guide for future research, and it can be used by researchers to identify other researchers they can collaborate with in FAW-related research.
Effect of Mammary Adenocarcinoma Supernatant on Hepatic Fibroblast Differentiation
Authors: Wang Enze , Zhang Xiangnan , Tao Ning 
Published: September 2022

Abstract
Mammary adenocarcinoma is the most common malignant tumor in women, and the liver is one of the sites with a high incidence of metastasis. This study established a mammary adenocarcinoma-associated fibroblast cell line (ME-iLX-2) that features premetasis niche based on coculture with the supernatant of hepatic stellate cells (LX-2) and mammary adenocarcinoma cells (TS/A). Multiple experiments, including 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)MTT, Flow Cytometry (FCM), wound-healing, lactic acid, real-time quantitative polymerase chain reaction (qPCR) and WB assays, were carried out to investigate the connection between mammary adenocarcinoma cells and hepatic stellate cells and the source of cancer-associated fibroblasts in the premetastatic microenvironment and to confirm the importance of vascular endothelial growth factor (VEGF) in mammary adenocarcinoma supernatant-induced hepatic fibroblast differentiation.
This study determined the following: 1. After long-term coculture with supernatant, LX-2 significantly promoted the proliferation and migration of tumor cells, and massive apoptosis of LX-2 cells occurred; 2. VEGF expression in LX-2 cells was positively correlated with the duration of coculture with supernatant. In addition, with an established linear regression model, high expression of VEGF is suggested to be one of the molecular properties of cancer-associated fibroblasts.
Detection of Antibodies against Toxoplasma from Human Serum Sample
using ELISA
Authors: Tak Vibhor , Sharma Kirtika , Srivastava Saumya , Kundu Aditya 
Published: September 2022

Background:
Toxoplasmosis is a common worldwide zoonotic infection affecting warm
blooded animals and humans caused by Toxoplasma gondii. Clinical features range from mildfebrile
illness and lymphadenopathy in the immunocompetent host to encephalitisin the immunosuppressed
host (E.g. HIV infected patients). Congenital infection can also occur. For effective control and treatment
of toxoplasmosis, accurate detection of T. gondii infection is important.

Objective:
In this study, ELISA detecting anti-toxoplasma antibodies IgM and IgG has been used for
diagnosing Toxoplasmosis in patients.

Methods:
Enzyme-linked immunosorbentassay (ELISA) was carried out in serum samples collected
from 40 patients to detect anti-toxoplasma IgG and IgM antibodies as a part of work up in suspected
cases. Relevant clinical history was also taken.

Result:
Of the total 40 samples taken, only one sample came positive for IgM and 9 came positive for
IgG antibody. All patients who were seropositivefor T. gondii antibodies had HIV infection. Five patients
were in the age group between 30 to 40 years.

Conclusion:
From the limited data available in this study, it may be recommended to screen for T.
gondii antibodies in HIV patients.
The Association Between Hematologic Indices with TIMI Flow in STEMI
Patients who Undergo Primary Percutaneous Coronary Intervention
Authors: Khaheshi Isa , Parsa Saeed Alipour , Nourian Saeed , Safi Morteza , Namazi Mohammad Hasan , Saadat Habib , Vakili Hossein , Eslami Vahid , Salehi Ayoub , Kiaee Farshid Heidarpour , Sohrabifar Nasim 
Published: September 2022

Background:
The Primary Percutaneous Coronary Intervention (PPCI) is the preferred
therapeutic strategy for patients who experienced ST-Elevation Myocardial Infarction (STEMI).

Objective:
We aimed to evaluate the association of hematological indices, including hemoglobin
level, platelets, White Blood Cells (WBCs) count, and MPV before PPCI with the TIMI grade flow
after PPCI.

Methods:
STEMI patients who experienced PPCI were included in the present retrospective crosssectional
study. Then participants were divided into three groups based on their post-procedural
TIMI flow grades. Demographic data and hematologic indices of patients before PPCI were collected
and their association with the TIMI grade flow after PPCI was evaluated. To compare the quantitative
and qualitative variables, chi-square and t-tests were performed, respectively.

Results:
We found that elevated levels of hemoglobin and decreased levels of MPV had a significant
association with an advanced grade of TIMI flow. Interestingly, in the normal range, there was
a significant association between higher platelet count and TIMI-flow grade 1. Besides, TIMI flow
grades 2 and 3 had a significant association with low and moderate platelets count, respectively.

Conclusion:
In conclusion, evaluating MPV, platelets, and hemoglobin levels before PPCI as easy
and accessible parameters may be able to identify high-risk STEMI patients undergoing PPCI.