bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolated hepatic perfusion as a treatment for uveal melanoma liver metastases, first results from a phase III randomized controlled multicenter trial (the SCANDIUM trial).
Authors: Olofsson Bagge Roger , Nelson Axel , Shafazand Amir , All-Ericsson Charlotta , Cahlin Christian , Elander Nils , Helgadottir Hildur , Kiilgaard Jens Folke , Kinhult Sara , Ljuslinder Ingrid , Rizell Magnus , Sternby Eilard Malin , Ullenhag Gustav J. , Nilsson Jonas A , Ny Lars , Lindner Per 
Published: June 2022

LBA9509 Background: Uveal melanoma is the most common primary intraocular malignancy in adults. Despite successful control of the primary tumor, metastatic disease will ultimately develop in approximately 50% of the patients, with the liver being the most common site. The median survival for patients with liver metastases is about 6-12 months, and there are only few systemic treatment options available that moderately prolong survival. A previous trial using isolated hepatic perfusion (IHP) has suggested a 14-month increase in overall survival, compared with a historical control group consisting of the longest surviving patients in Sweden during the same time period (26 vs. 12 months). Methods: In this multicenter randomized, controlled, phase III trial, patients with previously untreated isolated liver metastasis from uveal melanoma were randomized between 2013 and 2021 to receive IHP or best alternative care (control group). The primary end point is overall survival at 24 months, but here we report the secondary outcomes of response according to RECIST 1.1 criteria, progression-free survival (PFS), hepatic PFS (hPFS) and toxicity. Results: A total of 93 patients were randomized, with three patients in each group being excluded due to either withdrawal of consent or inappropriate enrollment, and a total of 87 patients were assigned to either IHP group (43 patients) or control group (44 patients). In the IHP group, 41 (89%) patients were treated per protocol, and in the control group, 49% of the patients were treated with chemotherapy, 39% with immunotherapy and 9% with localized treatment interventions. In an intention-to-treat analysis, the overall response rate (ORR) in the IHP group was 40% (17/43) compared to 4.5% (2/44) in the control group (p<0.0001). The median hPFS in the IHP group was 9.1 months (95% CI, 5.6 to 13.4 months), compared to 3.3 months (95% CI, 2.9 to 4.0 months) in the control group (p<0.0001). The median PFS in the IHP group was 7.4 months (95% CI, 5.2 to 11.6 months), compared to 3.3 months (95% CI, 2.9 to 3.7 months) in the control group (p<0.0001). There were 14 treatment-related serious adverse events in the IHP group, where vascular complication and infections were the most common side effects, compared to 13 in the control group where immunotherapy related side effects were most common. There was one treatment related death in the IHP group. Conclusions: Treatment with IHP resulted in superior ORR, hPFS and PFS compared to best alternative care among previously untreated patients with isolated uveal melanoma liver metastasis. Clinical trial information: NCT01785316.
Clinical, Genomic, and Transcriptomic Data Profiling of Biliary Tract Cancer Reveals Subtype-Specific Immune Signatures
Authors: Mody Kabir , Jain Prerna , El-Refai Sherif M. , Azad Nilofer S. , Zabransky Daniel J. , Baretti Marina , Shroff Rachna T. , Kelley R. Katie , El-Khouiery Anthony B. , Hockenberry Adam J. , Lau Denise , Lesinski Gregory B. , Yarchoan Mark 
Published: June 2022

PURPOSE Biliary tract cancers (BTCs) are aggressive cancers that carry a poor prognosis. An enhanced understanding of the immune landscape of anatomically and molecularly defined subsets of BTC may improve patient selection for immunotherapy and inform immune-based combination treatment strategies. METHODS We analyzed deidentified clinical, genomic, and transcriptomic data from the Tempus database to determine the mutational frequency and mutational clustering across the three major BTC subtypes (intrahepatic cholangiocarcinoma [IHC], extrahepatic cholangiocarcinoma, and gallbladder cancer). We subsequently determined the relationship between specific molecular alterations and anatomical subsets and features of the BTC immune microenvironment. RESULTS We analyzed 454 samples of BTC, of which the most commonly detected alterations were TP53 (42.5%), CDKN2A (23.4%), ARID1A (19.6%), BAP1 (15.5%), KRAS (15%), CDKN2B (14.2%), PBRM1 (11.7%), IDH1 (11.7%), TERT (8.4%), KMT2C (10.4%) and LRP1B (8.4%), and FGFR2 fusions (8.7%). Potentially actionable molecular alterations were identified in 30.5% of BTCs including 39.1% of IHC. Integrative cluster analysis revealed four distinct molecular clusters, with cluster 4 predominately associated with FGFR2 rearrangements and BAP1 mutations in IHC. Immune-related biomarkers indicative of an inflamed tumor-immune microenvironment were elevated in gallbladder cancers and in cluster 1, which was enriched for TP53, KRAS, and ATM mutations. Multiple common driver genes, including TP53, FGFR2, IDH1, TERT, BRAF, and BAP1, were individually associated with unique BTC immune microenvironments. CONCLUSION BTC subtypes exhibit diverse DNA alterations, RNA inflammatory signatures, and immune biomarkers. The association between specific BTC anatomical subsets, molecular alterations, and immunophenotypes highlights new opportunities for therapeutic development.
A novel route for sensing heavy metal ions in aqueous solution
Authors: Neog Ashamoni , Biswas Rajib 
Published: June 2022

Abstract
Heavy metal ions are some of the major aquatic pollutants which are held responsible for many ailments as well as undesired effects on flora and fauna. The World Health Organization has prescribed some permissible levels for each of the heavy metal ions. The presence of ions above permissible limits results in toxicity in the aquatic bodies as well as for other water-dependent living organisms. Therefore, it is necessary to make monitoring schemes to keep a check on the concentration of heavy metal ions. Considering this, here we report a unique route to detect heavy metal ions. Through chemical exfoliation, tungsten disulphide (WS2) nanosheets were prepared and drop casted on finger-like Cu electrodes to build the sensing unit. When the sensing unit was treated with heavy metal ions like Cu2+, Co2+, Pb2+, Hg2+, Sn2+ ions, rise in the current across the unit was observed. The concentrations of all the heavy metal ions were the same, i.e., 1 ppm. The maximum current gain was calculated for Cu2+ ions. It was found that the current gain for different ions is different in the voltage range 4–6 V and remains constant except for Cu2+ and Co2+ ions. It is believed that this novel route will pave the way for rapid and simultaneous sensing of different pervasive heavy metal ions in aqueous solutions.
Impact of a Fundamental Motor Skill Intervention on Low-Income Preschoolers’ Body Composition
Authors: Wadsworth Danielle D. , Spring Katherine E. , Johnson Jerraco L. , Carroll Alexandra V. , Sassi Julia , Suire Kameron B. , Pangelinan Melissa M. , Rudisill Mary E. 
Published: June 2022

ABSTRACT

Introduction/Purpose
Fundamental motor skills (FMS)—the building blocks of play, recreation, and sport—are deficient in overweight and obese children. FMS interventions may curb increasing childhood obesity rates. This randomized control trial aimed to determine the effect of an FMS intervention on fat mass (FM), fat-free mass (FFM), and body mass index (BMI) in preschool-aged children (ages 3–5 yr) attending a low-income preschool. Researchers hypothesized that children in the intervention would have increased FFM.

Methods
Eleven preschool classes (n = 136; mean age, 4.3 yr; 74% Black) were randomly assigned to the intervention (6 classes) or control (5 classes) groups. Participants in the intervention group attended a 30-min FMS intervention two times per week for 9 months, whereas the control group simultaneously participated in outdoor-free play. FM and FFM were measured with foot-to-foot bioelectrical impedance before and after intervention. BMI was measured using height and weight.

Results
At baseline, the control group had significantly more FM (t
76
= −2.12, P = 0.04) and FFM (t
76
= −2.59, P = 0.01) than the intervention group. A mixed-effects analysis of variance examined differences in FM, FFM, and BMI with respect to group, sex, and time. Significant time by group interactions were found for FM (P = 0.05), FFM (P = 0.01), and BMI (P = 0.05). The intervention group increased FM, FFM, and BMI by 12.93%, 9.11%, and 0.75%, respectively, whereas the control group increased FM, FFM, and BMI by 23.60%, 12.75%, and 5.30%, respectively.

Conclusions
The findings of the current study suggest that an FMS intervention can delay additions of FM. It is further evident that increases in FM occurred at an alarming rate in primarily Black preschool children from a low-income center. The findings emphasize the importance of FMS in obesity prevention and measuring body composition in preschool children.
PROFILES with the CanMEDS model as a guiding framework for conveying basics in clinical medicine and physician roles to health sciences students: a qualitative study
Authors: Odermatt Florence , Schirlo Christian , Babst Reto , Gysin Stefan 
Published: June 2022

Background: PROFILES (Principal Relevant Objectives and Framework for Integrative Learning and Education in Switzerland), a competency-based framework for medical students in Switzerland, was used to structure a course aiming at conveying the roles of physicians and basics in clinical medicine to health sciences students. The goal of this study was to explore how this approach was experienced and perceived by students, lecturers and experts. Methods: For this explorative qualitative study, semi-structured interviews with seven students, four lecturers and two experts in medical education were held, and themes were identified by conducting a thematic analysis by Braun and Clarke. Results: We identified four themes: (1) PROFILES as a guiding framework, (2) strengths and weaknesses of the course, (3) general teaching aspects and (4) potential benefits for future interprofessional collaboration. Some students initially struggled to comprehend the novel approach, but overall, the structure of the course was positively perceived by most interviewees, especially lecturers and experts. Conclusions: PROFILES, particularly the integrated CanMEDS model, may be suitable to convey the roles and tasks of physicians and basic medical knowledge to health sciences students. Further studies are required to evaluate the effects on potential interprofessional collaboration.
3D noise photon transfer curve
Authors: Preece Bradley L. , Haefner David P. 
Published: June 2022

A photon transfer curve (PTC) is used to determine fundamental detector noise parameters such as read noise, conversion gain, and fixed pattern noise. Here, the method for determining a PTC is expanded to include 3D noise parameters. 3D noise PTC provides more insight into detector noise and is treated as the next logical step to classical PTC. However, it induces several new challenges in analyzing the results, specifically the fitting of seven, or more, variance curves compared to the one (total variance) or two (temporal and fixed pattern variance) prior. Therefore, a general measurement model is created, which provides a new method to separate out all the classical terms, such as DSNU and PRNU, but can also handle high gain cameras with a noise factor. This method is then verified using Monte Carlo simulations and applied to a commercial machine vision camera. In addition, the effects of lens vignetting and non-uniformity correction (NUC) are explored, along with a comparison of the single pixel PTC.
Zum Erbbauzinssatz: Das Rätsel um die Marktgerechtigkeit
Authors: Löhr Dirk 
Published: June 2022

ZusammenfassungDer Erbbauzins ist bei kommunalen Erbbaurechten sowohl eine zentrale Stellgröße für die Wirtschaftlichkeit als auch von kommunalwirtschafts- und beihilferechtlicher Relevanz. Er wird zumeist ermittelt, indem ein geeigneter Erbbauzinssatz auf den Bodenwert angelegt wird. Der Erbbauzinssatz sollte dabei marktgerecht sein. Sowohl die Ableitung des Erbbauzinssatzes aus dem Primärmarkt (erstmalige Ausgabe von Erbbaurechten) wie aus dem Sekundärmarkt (Weiterverkäufe) ist aber zumindest bei Erbbaurechten für Mehrfamilienhäuser derzeit kaum sinnvoll zu diesem Zwecke durchzuführen. Auch der Liegenschaftszinssatz ist ungeeignet, da er aus einem Modell für Volleigentum mit einer vollkommen anderen Risiko-/Rendite-Konstellation abgeleitet wird. Daher wird für eine stärkere Anwendung ökonomisch basierter Verfahren plädiert und hierbei ein kapitalmarktorientiertes Mark-to-Model-Verfahren dargestellt. Erste überschlägige Ermittlungen legen zudem die Orientierung an langfristigen Baufinanzierungssätzen als Daumenregel nahe. Regelmäßig dürften von Kommunen für die Ermittlung von marktgerechten Erbbauzinssätzen öffentlich bestellte und vereidigte oder zertifizierte Grundstückssachverständige betraut werden, denen die betreffenden Verfahren jedoch oftmals fremd sind. Auch stellt sich die Frage nach der Zulässigkeit, da sie sich als Best Practice-Verfahren bislang nicht etabliert haben. Daher wäre dem Gesetz- bzw. Verordnungsgeber anzuraten, die Ermittlung marktgerechter Erbbauzinssätze ausdrücklich zu regeln und dabei jenseits von Mark-to-Market-Verfahren weitere geeignete ökonomisch gestützte Methoden wie auch empirisch abgesicherte „Daumenregeln“ zuzulassen.
The competing effects of racial discrimination and racial identity on the predicted number of days incarcerated in the US: A national profile of Black, Latino/Latina, and American Indian/Alaska Native populations
Authors: Pro George , Camplain Ricky , Lea Charles H. 
Published: June 2022

Objective
Racial discrimination and racial identity may compete to influence incarceration risk. We estimated the predicted days incarcerated in a national US sample of Black, Latino/Latina, and American Indian/Alaska Native (AI/AN) individuals.

Methods
We used the 2012–2013 National Epidemiologic Survey on Alcohol and Related Conditions-III (n = 14,728) to identify individual incarceration history. We used zero-inflated Poisson regression to predict the number of days incarcerated across racial discrimination and racial identity scores.

Results
Racial discrimination and identity varied between races/ethnicities, such that racial discrimination exposure was highest among Hispanic individuals, while racial identity was highest among Black individuals. Racial discrimination was positively associated with days incarcerated among Black individuals (β = 0.070, p<0.0001) and AI/AN individuals (β = 0.174, p<0.000). Racial identity was negatively associated with days incarcerated among Black individuals (β = -0.147, p<0.0001). The predicted number of days incarcerated was highest among Black individuals (130 days) with high discrimination scores.

Conclusion
Racial discrimination and racial identity were associated with days incarcerated, and the association varied by racial/ethnic sub-group. Informed by these findings, we suggest that intervention strategies targeting incarceration prevention should be tailored to the unique experiences of racial/ethnic minoritized individuals at the greatest risk. Policies aimed at reversing mass incarceration should consider how carceral systems fit within the wider contexts of historical racism, discrimination, and structural determinants of health.
Impacts of service quality, brand image, and perceived value on outpatient’s loyalty to China’s private dental clinics with service satisfaction as a mediator
Authors: Lin Wenyi , Yin Wanxia 
Published: June 2022

Background
This study explores the effects and influence paths of service quality, brand image, perceived value, and service satisfaction on outpatients’ loyalty to China’s private dental clinics.

Methods
A cross-sectional survey study was conducted in Dongguan City, Guangdong Province, China in January 2019. The participants were selected using the convenience sampling method. Of the 230 residents surveyed, 125 had received services in private dental clinics, being the valid sample of this study. A multiple linear regression model was used in exploring factors influencing patient loyalty. Subsequently, the path analysis was used in investigating the relationships among service quality, brand image, perceived value, patient satisfaction, and patient loyalty.

Results
After the effects of demographic and socioeconomic variables were controlled, perceived value and patient satisfaction showed significant influences on patient loyalty. Path analysis indicated that perceived value, perceived quality, and expected quality have direct effects on patient satisfaction and have indirect effects on patient loyalty, and patient satisfaction is a mediator.

Conclusion
Perceived service quality influences patient loyalty through the effect of patient satisfaction, which plays a key role in promoting patient loyalty. This study implies that managers in private dental clinics can gain support from customers by building customer loyalty toward dental clinics.
STUDI SUSUT DAYA JARINGAN DISTRIBUSI PRIMER AREA LUWUK MELALUI SIMULASI ALIRAN DAYA MENGGUNAKAN METODE NEWTON RAPHSON
Authors: Winarta I Kadek , Harun Ervan Hasan , Giu Jamal Darusalam 
Published: June 2022

Jaringan distribusi primer area Luwuk adalah jaringan yang terisolasi dari sistem transmisi Sulutenggo. Tenaga listrik di wilayah Luwuk bersumber dari pembangkit listrik tenaga diesel dan mesin gas yang disalurkan pada 14 penyulang untuk melayani Kota Luwuk dan sekitarnya. Semakin panjang suatu penyulang, maka semakin besar nilai impedansinya, yang mengakibatkan susut daya pada jaringan distribusi. Studi aliran daya dengan metode Newton Raphson digunakan untuk mengetahui besar susut daya pada sistem tenaga listrik. Hasil studi aliran daya menunjukkan terjadi susut daya aktif pada jaringan distribusi primer area Luwuk sebesar 605 kW dengan persentase susut 3,4% dan susut daya reaktif sebesar 576 kVAR (8,41%) dan terjadi penurunan tegangan yang melampaui batas minimum tegangan pelayanan pada ujung penyulang Salodik yaitu -10,95%. Dengan penambahan kapasitor bank sebesar 100 kVAr pada ujung penyulang Salodik, nilai penurunan tegangan pada penyulang tersebut berkurang dari -10,95% menjadi -7,85% sehingga memenuhi batas minimum tegangan pelayanan, dan terjadi penurunan susut daya aktif menjadi 591 kW (3,32%) dan susut daya reaktif menjadi 555 kVAR (8,19%). Kerugian energi listrik yang dialami PLN perbulan pada distribusi primer area Luwuk adalah 435.600 kWh, dengan estimasi kerugian Rp.629.311.320. Setelah perbaikan, kerugian energi menjadi 425.520 kWh atau Rp.614.748.744 sehingga terjadi penurunan kerugian PLN sebesar Rp. 14.562.576 perbulan.
English medium instruction in Higher Education of Afghanistan: students’ perspective
Authors: Orfan Sayeed Naqibullah , Seraj Muhammad Yaqoob 
Published: June 2022

Abstract
The study investigated students’ views of reasons for the adoption of English medium instruction (EMI) in Afghan Higher Education, EMI effects on official languages and students’ preference of medium of instruction. It also explored whether students’ gender, first language and English proficiency had any significant impact on their responses. The data were collected from 840 students by means of an online questionnaire from four public universities based in northeastern Afghanistan. The dataset was analyzed using descriptive and inferential statistics. The results showed that students had a positive attitude towards EMI in higher education. They believed that the universities should adopt EMI for various reasons, e.g., internationalization of universities. They were aware of the negative effects of EMI on the official languages of Afghanistan. They were more likely to select a combination of English and official languages for the medium of instruction. Students’ gender and first language did not have a significant impact on their attitudes towards EMI; however, their English proficiency significantly impacted their attitudes towards EMI. Moreover, their gender and first language, and English proficiency had significant effects on their preference of language of instruction. The study suggests a policy for gradual transition to bilingual education in Higher Education.
‚Rechte Gegenwartsliteratur‘?
Authors: Busch Nicolai 
Published: June 2022

Abstract
Ever since Botho Strauß’ essay Anschwellender Bocksgesang (1993), contemporary literary texts and authors in Germany have been repeatedly valued as “right-wing”. Due to an ongoing shift of the political landscape, leading to changes in the meaning of right or left, this article suggests analyzing the social and discursive conditions which constitute the political evaluation of literature.
Dynastic Genealogies and Funerary Monuments: Nectanebo, Alexander, and Judas Maccabee and the Evidence of Ptolemaic Influence on the Hasmoneans
Authors: Honigman Sylvie , Gorre Gilles 
Published: June 2022

AbstractWhen we compare the genealogical strategies of the Ptolemies, Seleukids, and Hasmoneans, those of the Ptolemies and the Hasmoneans display striking parallels, while the Seleukids followed a different policy. This article explores one facet of the parallels, the combined use of funerary monuments, festivals, and narratives (mythical and historical) to create prestigious dynastic ancestors. We commence with Alexander the Great and Nectanebo II, the last native king to rule before the Persian conquest of Egypt, who became putative ancestors of the Ptolemies by way of Alexander’s Sema in Alexandria, the Ptolemaic ruler cult, and four texts—theDemotic Chronicle,Nectanebo’s Dreamand its “sequel”, and theAlexander Romance. The comparison between the Ptolemies and the Hasmoneans focuses on Alexander’s Sema and the Hasmonean funerary monument erected by Simon in Modi’in. Alongside their physical similarities, we show how the Modi’in monument was instrumental in turning the Hasmonean John Hyrkanos into the heir of all the tomb dwellers, particularly Judas Maccabee.
Roman Economic History from Coins and Papyri: Monetary Value, Trust and Crisis
Authors: de Bree Philippus 
Published: June 2022

AbstractThis paper attempts to quantify the development of the key monetary values and changes in monetary trust that occurred during Roman times under ever-increasing prices. To track those developments, the paper introduces a minimal-parameter model that builds on available numismatic data relating to the Roman landmark coinages and on papyrological findings. The modelling produces a series of graphs which clearly signal the occurrence of a later crisis of confidence. It is argued that the monetary measures typically taken by the Roman authorities actually fostered a crisis of confidence, and even made it inevitable.
Time and finance optimization model for multiple construction projects using genetic algorithm
Authors: Hasan Musaab Falih , Mohammed Sawsan Rasheed 
Published: June 2022

Abstract
Construction contractors usually undertake multiple construction projects simultaneously. Such a situation involves sharing different types of resources, including monetary, equipment, and manpower, which may become a major challenge in many cases. In this study, the financial aspects of working on multiple projects at a time are addressed and investigated. The study considers dealing with financial shortages by proposing a multi-project scheduling optimization model for profit maximization, while minimizing the total project duration. Optimization genetic algorithm and finance-based scheduling are used to produce feasible schedules that balance the finance of activities at any time with the available funds. The model has been tested in multi scenarios, and the results are analyzed. The results show that negative cash flow is minimized from −693,784 to −634,514 in enterprise I and from −2,646,408 to −2,529,324 in enterprise II in the first scenario and also results show that negative cash flow is minimized to −612,768 with a profit of +200,116 in enterprise I and to −2,597,290 with a profit of +1,537,632 in enterprise II in the second scenario.