bluuebunny/crossref_metadata_2025_split huggingface dataset:
Directing Multicellular Organization by Varying the Aspect Ratio of Soft Hydrogel Microwells
Authors: Pahapale Gayatri J. , Tao Jiaxiang , Nikolic Milos , Gao Sammy , Scarcelli Giuliano , Sun Sean X. , Romer Lewis H. , Gracias David H. 
Published: April 2022

AbstractMulticellular organization with precise spatial definition is essential to various biological processes, including morphogenesis, development, and healing in vascular and other tissues. Gradients and patterns of chemoattractants are well‐described guides of multicellular organization, but the influences of 3D geometry of soft hydrogels are less well defined. Here, the discovery of a new mode of endothelial cell self‐organization guided by combinatorial effects of stiffness and geometry, independent of protein or chemical patterning, is described. Endothelial cells in 2 kPa microwells are found to be ≈30 times more likely to migrate to the edge to organize in ring‐like patterns than in stiff 35 kPa microwells. This organization is independent of curvature and significantly more pronounced in 2 kPa microwells with aspect ratio (perimeter/depth) < 25. Physical factors of cells and substrates that drive this behavior are systematically investigated and a mathematical model that explains the organization by balancing the dynamic interaction between tangential cytoskeletal tension, cell–cell, and cell–substrate adhesion is presented. These findings demonstrate the importance of combinatorial effects of geometry and stiffness in complex cellular organization that can be leveraged to facilitate the engineering of bionics and integrated model organoid systems with customized nutrient vascular networks.
Dual Modulation of Single Molecule Conductance via Tuning Side Chains and Electric Field with Conjugated Molecules Entailing Intramolecular O•••S Interactions
Authors: Zhang Hua , Xu Wei , Song Kai , Lu Taige , Zhang Guanxin , Zang Yaping , Hong Wenjing , Zhang Deqing 
Published: April 2022

AbstractHerein, single‐molecule conductance studies of TBT1‐TBT6 which entails 1,4‐dithienylbenzene as the backbone and SMe groups as the anchoring units, with the scanning tunneling microscope break junction (STM‐BJ) technique, are reported. The molecular conductance of TBT1 with intramolecular O•••S noncovalent interactions is enhanced by about one order of magnitude in comparison to their analogue TBT2 (which contains alkyl instead of alkoxy chains). By replacing the methoxy groups in TBT1 with extending alkoxy chains in TBT3, TBT4, and TBT5, the molecular backbones become twisted and as a consequence the single‐molecule conductance decreases gradually, showing that the intramolecular O•••S noncovalent interaction is influenced by the structural features of alkoxy chains. More importantly, the single‐molecule conductance of TBT3, TBT4, and TBT5 can be boosted by increasing the electric field applied to the molecular junctions. Remarkably, the conductance of TBT3, TBT4, and TBT5 can be reversibly modulated due to the conformational changes between twisted and planar ones by varying the electric field. These results demonstrate that molecules with intramolecular O•••S noncovalent interactions have the potential for in situ control of the electrical properties of molecular‐scale devices.
Electronically Reconfigurable Photonic Switches Incorporating Plasmonic Structures and Phase Change Materials
Authors: Farmakidis Nikolaos , Youngblood Nathan , Lee June Sang , Feldmann Johannes , Lodi Alessandro , Li Xuan , Aggarwal Samarth , Zhou Wen , Bogani Lapo , Pernice Wolfram HP , Wright C David , Bhaskaran Harish 
Published: April 2022

AbstractThe ever‐increasing demands for data processing and storage will require seamless monolithic co‐integration of electronics and photonics. Phase‐change materials are uniquely suited to fulfill this function due to their dual electro‐optical sensitivity, nonvolatile retention properties, and fast switching dynamics. The extreme size disparity however between CMOS electronics and dielectric photonics inhibits the realization of efficient and compact electrically driven photonic switches, logic and routing elements. Here, the authors achieve an important milestone in harmonizing the two domains by demonstrating an electrically reconfigurable, ultra‐compact and nonvolatile memory that is optically accessible. The platform relies on localized heat, generated within a plasmonic structure; this uniquely allows for both optical and electrical readout signals to be interlocked with the material state of the PCM while still ensuring that the writing operation is electrically decoupled. Importantly, by miniaturization and effective thermal engineering, the authors achieve unprecedented energy efficiency, opening up a path towards low‐energy optoelectronic hardware for neuromorphic and in‐memory computing.
Harvesting Water‐Evaporation‐Induced Electricity Based on Liquid–Solid Triboelectric Nanogenerator
Authors: Chi Jingu , Liu Chaoran , Che Lufeng , Li Dujuan , Fan Kai , Li Qing , Yang Weihuang , Dong Linxi , Wang Gaofeng , Wang Zhong Lin 
Published: April 2022

AbstractHarvesting energy from natural water evaporation has been proposed as a promising alternative to supply power for self‐powered and low‐power devices and systems, owing to its spontaneous, ubiquitous, and sustainability. Herein, an approach is presented for harvesting water‐evaporation‐induced electricity based on liquid–solid triboelectric nanogenerators (LS‐TENGs), which has various advantages of easy preparation, substrate needless, and robustness. This developed harvester with porous Al2O3 ceramic sheet can generate a continuous and stable direct current of ≈0.3 µA and voltage of ≈0.7 V by optimizing the sheet physical dimensions and ambient parameters such as relative humidity, temperature, wind velocity, and ion concentration. The output power also can be improved significantly by series or parallel connection the harvesters, which has superior electrical compatibility and environmental suitability. The development of the water‐evaporation‐induced electricity harvesting shows many application prospects including power supply for digital calculator and charging capacitor. This research provides an in‐depth experimental study on water‐evaporation‐induced electricity harvesting based on LS‐TENGs and an efficient approach to supply electricity for low‐power devices.
Effects of temperature on farmed marine polychaete Perinereis helleri and its fatty acid profile
Authors: Hoang Tung , Murphy Brian , Kim Lee Chang , Stratford Chris , Stevenson Chris 
Published: April 2022

AbstractThis study investigated short‐term effects of temperature on survival, body weight and the fatty acid profile of farmed marine polychaete Perinereis helleri—an excellent live feed maturation diet for penaeid shrimp broodstock. Two consecutive experiments were conducted to evaluate the effects of low temperature (4, 8, 12, 16 and 20°C) and high temperature (20, 24, 28, 32 and 36°C) on a 7‐month‐old population of P. helleri farmed at Bribie Island Research Centre, Australia. The experimental polychaetes were purged for 24 h at 20°C before being transferred directly into 500 ml glass chambers, sealed and submersed in different target temperature water baths. The jars were then kept for 3 or 6 h in the low‐temperature experiment and 1 or 3 h in the high‐temperature experiment, respectively. Results showed that mortality occurred only at 4°C and 8°C (p < 0.01). Weight loss occurred across all treatments of the low‐temperature experiment, but only at 36°C in the high‐temperature one. Analysis of lipid classes and fatty acids show that farmed P. helleri is rich in polyunsaturated fatty acids (PUFA, i.e. 37% of total fatty acids), especially arachidonic acid (ARA, 20:4n‐6). The total value of essential fatty acids was 15.8% of total fatty acids or 16.8 mg/g dry matter. The n‐3:n‐6 ratio was 1.07 ± 0.04. This study suggests that P. helleri can be transported at ambient temperature of 16–20°C and can be farmed in a tropical climate.
A near‐infrared probe for detecting and interposing amyloid beta oligomerization in early Alzheimer's disease
Authors: Quan Li , Moreno‐Gonzalez Ines , Xie Zhigang , Gamez Nazaret , Vegas‐Gomez Laura , Song Qinyong , Gu Jianhua , Lin Wenhai , Gomez‐Gutierrez Ruben , Wu Tianfu 
Published: April 2022

AbstractBackgroundThe misfolding and deposition of amyloid beta (Aβ) in human brain is the main hallmark of Alzheimer's disease (AD) pathology. One of the drivers of Alzheimer´s pathogenesis is the production of soluble oligomeric Aβ, which could potentially serve as a biomarker of AD.MethodsGiven that the diphenylalanine (FF) at the C‐terminus of Aβ fragments plays a key role in inducing the AD pathology, based on the hydrophobic structure of FF, we synthesized a near‐infrared BF2‐dipyrrolmethane fluorescent imaging probe (NB) to detect both soluble and insoluble Aβ.ResultsWe found that NB not only binds Aβ, particularly oligomeric Aβ, but also interposes self‐assembly of Aβ through π‐π interaction between NB and FF.ConclusionThis work holds great promise in the early detection of AD and may also provide an innovative approach to decelerate and even halt AD onset and progression.
Generalized Gauge Transformation with PT$PT$‐Symmetric Non‐Unitary Operator and Classical Correspondence of Non‐Hermitian Hamiltonian for a Periodically Driven System
Authors: Gu Yan , Hao Xiao‐Lei , Liang Jiu‐Qing 
Published: April 2022

AbstractThis paper demonstrates that the parity‐time ()‐symmetric non‐Hermitian Hamiltonian for a periodically driven system can be generated from a kernel Hamiltonian by a generalized gauge transformation. The kernel Hamiltonian is Hermitian and static, while the time‐dependent transformation operator has to be symmetric and non‐unitary in general. Biorthogonal sets of eigenstates appear necessarily as a consequence of the non‐Hermitian Hamiltonian. The wave functions and associated non‐adiabatic Berry phase for the nth eigenstate are obtained analytically. The classical version of the non‐Hermitian Hamiltonian becomes a complex function of canonical variables and time. The corresponding kernel Hamiltonian is derived with symmetric canonical‐variable transfer in the classical gauge transformation. Moreover, with the change of position‐momentum to angle‐action variables it is revealed that the non‐adiabatic Hannay's angle and Berry phase satisfy precisely the quantum‐classical correspondence, .
Well‐ordered nanostructured organic/inorganic hybrid thin film construction via UV nanoimprint lithography applicable to liquid crystal systems
Authors: Lee Dong Wook , Won Jong Hoon , Kim Dong Hyun , Oh Jin Young , Kim Dae‐Hyun , Liu Yang , Seo Dae‐Shik 
Published: April 2022

AbstractIn this study, a well‐ordered unidirectional nanostructure was successfully imprinted on a UV curable polymer/indium oxide hybrid film using UV nanoimprint lithography (NIL). The surface morphologies of the hybrid films were analyzed by atomic force microscopy (AFM), and the uniform nanostructure with a period of 820 nm and height of 30 nm was observed on a 6 min UV‐irradiated film by line profile from AFM. The chemical modification of the films according to UV irradiation time was analyzed by X‐ray photoelectron spectroscopy. The nanopatterned hybrid film was applied to the liquid crystal (LC) alignment layer and the polarized optical microscopy and pretilt angle analysis demonstrated the highly uniform and homogeneous LC alignment state. The unidirectional nanostructure guided the LCs orientation and the aligned surface anisotropy which induces the uniform LC alignment. The hybrid film chemical affinity was analyzed by contact angle measurement, and the increased surface energy after UV irradiation contributed to the homogeneous LC alignment. Therefore, various organic/inorganic hybrid films can be used for nanostructure construction via UV NIL, and it has a high potential for application in diverse LC systems.
Managing entrepreneurial and corporate contributions to sustainability transitions
Authors: Schaltegger Stefan , Loorbach Derk , Hörisch Jacob 
Published: April 2022

AbstractTo achieve an economy within ecological boundaries that meets the needs of all requires societal transitions (i.e. systemic changes of collective cultures, structures and practices). Such a societal and economic transition requires corporate and entrepreneurial organisations to transform their businesses, business models and societal roles. While the importance of companies for sustainable development has been acknowledged in the existing literature the link between transformations at the organizational level and sustainability transitions beyond organizational boundaries needs further investigation. This contribution therefore unpacks the duality of companies in sustainability transitions: they are subject to the transformative changes in the economy and society, and they can be leaders of sustainability transitions of the economy and society. Companies are challenged to proactively manage a simultaneous build‐up of sustainable and phase‐out of unsustainable products, services and practices. Key approaches for sustainability transformation management are discussed and conclusions for research and practice deducted.
Advertising strategies and sustainable development: The effects of green advertising appeals and subjective busyness on green purchase intention
Authors: Dai Jiatong , Sheng Guanghua 
Published: April 2022

AbstractAs environmental issues receive global attention, sustainable development has gradually become a crucial element of business strategies. A considerable number of enterprises have practiced green innovations and introduced green products to the market. A key issue in realizing the sustainability of business strategies is to motivate consumers to purchase green products through effective green advertising strategies. When promoting green products, corporates commonly face a crucial decision that which type of appeals should be employed to enhance the effectiveness of green advertising strategies. Based on the Theory of Self‐regulation and Theory of Self‐congruency, this study aims to propose and examine a conceptual model to uncover how advertising appeals affect the green purchase intention of consumers with different subjective feelings of busyness. Four experimental studies were conducted, and the results reveal that the other‐benefiting appeal stimulates higher self‐image congruency of subjectively busy consumers and therefore boosts green purchase intention. The self‐benefiting appeal activates functional congruency of consumers with low subjective busyness, thus increasing purchase intention. Furthermore, only in the context of high environmental accountability could the other‐benefiting appeal induce higher green purchase intention of subjectively busy consumers. Managerially, the findings guide practitioners on employing advertising appeals reasonably to maximize the effectiveness of green advertising strategies by considering consumers' subjective busyness.
Who could complete and benefit from the adjuvant chemotherapy regarding pancreatic ductal adenocarcinoma? A multivariate‐adjusted analysis at the pre‐adjuvant chemotherapy timing
Authors: Fu Ningzhen , Qin Kai , Li Jingfeng , Jin Jiabin , Jiang Yu , Deng Xiaxing , Shen Baiyong 
Published: April 2022

AbstractBackgroundThe pre‐adjuvant chemotherapy (PAC) status of postoperative pancreatic ductal adenocarcinoma (PDAC) patients has not been studied and elaborated well previously.MethodThe association of PAC variables and prognoses was explored using a multivariable Cox model, restricted cubic spline analysis, and correlation analysis. The main outcomes were overall survival (OS) and progression‐free survival (PFS). The secondary outcome was chemotherapy completeness (CHC).ResultsA total of 401 eligible patients were enrolled in sequential surgery and chemotherapy. The chemotherapy regimen, PAC fasting blood glucose (FBG), and elevated fasting blood glucose (eFBG) status were associated with CHC (regimen types: p = 0.005, continuous FBG: p = 0.014, eFBG status: p = 0.012). Early administration of adjuvant chemotherapy (<34 days) was a risk factor for the limited OS and PFS (OS: aHR: 1.61 [1.09–2.38], p = 0.016; PFS: aHR: 1.91 [1.29–2.82], p = 0.001). Patients with higher PAC body mass index (BMI), receiving Gemcap regimen, and with lower PAC tumor marker value were observed with better survival prognoses (PAC BMI: OS: 0.927 [0.875–0.983], p = 0.011; Gemcap: OS: 0.533 [0.312–0.913], p = 0.022; Gemcap: PFS: 0.560 [0.341–0.922], p = 0.023; PAC CA125: OS: 1.004 [1.002–1.006], p < 0.001; PAC CA125: PFS: 1.003 [1.000–1.005], p = 0.031; PAC CEA: OS: 1.050 [1.026–1.074], p < 0.001). The BMI decrease was mainly concentrated in the first 3 months of chemotherapy courses (first 3 months: p < 0.001; latter 3 months: p = 0.097). And CEA, compared to CA125 and CA199, was a better prognostic indicator (CEA: first 3 months: PFS p = 0.011, OS p < 0.001; latter 3 months: PFS p = 0.024, OS p = 0.041).ConclusionPDAC patients should be treated with adjuvant chemotherapy over 34 postoperative days. PAC sarcopenia was a risk factor for OS, but not PFS and limited CHC. Those with higher PAC FBG levels were more likely to finish chemotherapy. CEA, compared to CA125 and CA199, was a better prognostic indicator.
Myocarditis following COVID‐19 mRNA (mRNA‐1273) vaccination
Authors: Chellapandian Suresh Babu , Turkmen Suha , Salim Imtiaz , Chinnakaruppan Shanmugavel , Mohammad Jassim 
Published: April 2022

AbstractIn this case report, we presented a case of myocarditis as a rare complication that developed after Covid mRNA‐1273 vaccine. Cases of post‐vaccine myocarditis usually progress with mild symptoms. However, it should be a situation that healthcare workers should keep in mind, that myocarditis may develop after vaccination.
Snake in right coronary artery—Extensive spontaneous coronary artery dissection in a young male
Authors: Vohra Shweta , Pradhan Akshyaya , Sharma Prachi , Jaiswal Vikash , Pokhrel Nishan Babu 
Published: April 2022

AbstractWe report an interesting case of a young man who revealed extensive spontaneous dissection of the RCA in diagnostic angiography. It was surprising that despite an extensive dissection, the patient remained hemodynamically stable on medical management throughout the procedure and during the post‐procedure hospital stay.
Delayed right ventricular lead perforation by a pacemaker lead 2‐year post‐implantation
Authors: Yamamoto Akihiro , Takahashi Shoichi 
Published: April 2022

AbstractCardiac perforation by the lead of cardiac implantable electronic devices is a critical complication that often occurs within 24 h after the implantation but can occur later. We report a case of cardiac perforation of the right ventricular wall during the chronic period, 2 years after pacemaker implantation.
Coronal brain atlas in stereotaxic coordinates of the African spiny mouse, Acomys cahirinus
Authors: Vitorino Marta , Simão Sónia , Moreira João B. , Nogueira‐Rodrigues Joana , Silva Joana , Lourenço Ana Sofia , Fernandes Vítor , Sousa Monica M. , Tiscornia Gustavo , Araújo Inês M. 
Published: April 2022

AbstractThe African spiny mouse (Acomys cahirinus) is an emerging model of mammalian epimorphic regeneration that has aroused the interest of the scientific community in the last decade. To date, studies on brain repair have been hindered by the lack of knowledge on the neuroanatomy of this species. Here, we present a coronal brain atlas in stereotaxic coordinates, which allows for three‐dimensional identification and localization of the brain structures of this species. The brain of 12‐week‐old spiny mice was mapped in stereotaxic coordinates using cresyl violet‐stained brain sections obtained from coronal cryosectioning of the brain after transcardial perfusion with fixative. The atlas is presented in 42 plates representing sections spaced 240 μm apart. Stereotaxic coordinates were validated using both a model of Parkinsonian lesion of the striatum with 6‐hydroxydopamine and labeling of the corticospinal tract in the spiny mouse spinal cord using AAV1/2‐GFP intracortical injections. This work presents a new tool in A. cahirinus neurobiology and opens new avenues of research for the investigation of the regenerative ability of A. cahirinus in models of brain disorders.
The In Vitro Differentiation of Human CD141+CLEC9A+ Dendritic Cells from Mobilized Peripheral Blood CD34+ Hematopoietic Stem Cells
Authors: Swartz Adam M. , Nair Smita K. 
Published: April 2022

AbstractAs shown in various preclinical studies, conventional type‐1 dendritic cells, or cDC1s, play a critical role in the immunological rejection of tumors and in the defense against pathogens. This indispensability stems from their potent capacity to activate cytotoxic T cells, especially via the cross‐presentation of exogenous antigens. For this reason, cDC1s have become an attractive target for immunotherapy. Here we report a simplified method for generating large numbers of cDC1‐like cells in vitro from mobilized human peripheral blood CD34+ hematopoietic stem cells using FMS‐like tyrosine kinase 3 ligand (FLT3L) and granulocyte‐macrophage colony‐stimulating factor (GM‐CSF). An important aspect of this Protocol is the growth of cells on a non‐tissue culture‐treated surface rather than on a tissue culture‐treated surface since the latter suppresses cDC1‐marker expression. The resulting CD11c+ DCs express high levels of cDC1‐specific markers such as CD141, CLEC9A, TLR3, and several DC maturation markers. Compared to alternative differentiation methods, this method generates large numbers of cDC1‐like cells without the need for immortalized feeder cells and should prove useful for studying cDC1 immunobiology and clinical applications of this DC subset. © 2022 Wiley Periodicals LLC.Basic Protocol: Generation of human CD141+CLEC9A+ dendritic cells from mobilized peripheral blood CD34+ hematopoietic stem cellsSupport Protocol: Flow cytometric immunophenotyping of CD141+ dendritic cells
Hybrid invasive weed optimization and squirrel search algorithm‐based NLOS nodes localization mechanism for improving reliable data dissemination in VANETs
Authors: Mani Rajendran , Jayaraman Sasikala , Ellappan Mohan 
Published: April 2022

SummaryIn emergency situations, the localization of Non Line of Sight (NLOS) nodes is essential for enhancing the reaction time of the vehicle drivers in response to the stimulus generated in VANETs. However, the existence of NLOS nodes intentionally or intentionally introduces broadcasting storm and congestion in the network. In this paper, a Hybrid Invasive Weed Optimization and Squirrel Search Algorithm‐Localization Mechanism (HIWO‐SSA‐LM) is proposed for improving the localization of NLOS nodes to enhance the reliable data dissemination under emergency situations in VANETs. This proposed HIWO‐SSA‐LM integrates the reproductive capability of Invasive Weeds into the reproductive potential of a Flying Squirrel Algorithm for sustaining the degree of balance under exploitation and exploration involved during NLOS node localization. The predominance of the proposed HIWO‐SSA‐LM is explored based on experiments conducted using EstiNet 8.1 simulator using emergency message delivery rate, channel utilization rate, and neighborhood awareness rate by varying the number of vehicles and NLOS nodes in the network.