bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delineating cooperative effects of Notch and biomechanical signals on patterned liver differentiation
Authors: Jain Ishita , Berg Ian C. , Acharya Ayusha , Blaauw Maddie , Gosstola Nicholas , Perez-Pinera Pablo , Underhill Gregory H. 
Published: October 2022

AbstractControlled in vitro multicellular culture systems with defined biophysical microenvironment have been used to elucidate the role of Notch signaling in the spatiotemporal regulation of stem and progenitor cell differentiation. In addition, computational models incorporating features of Notch ligand-receptor interactions have provided important insights into Notch pathway signaling dynamics. However, the mechanistic relationship between Notch-mediated intercellular signaling and cooperative microenvironmental cues is less clear. Here, liver progenitor cell differentiation patterning was used as a model to systematically evaluate the complex interplay of cellular mechanics and Notch signaling along with identifying combinatorial mechanisms guiding progenitor fate. We present an integrated approach that pairs a computational intercellular signaling model with defined microscale culture configurations provided within a cell microarray platform. Specifically, the cell microarray-based experiments were used to validate and optimize parameters of the intercellular Notch signaling model. This model incorporated the experimentally established multicellular dimensions of the cellular microarray domains, mechanical stress-related activation parameters, and distinct Notch receptor-ligand interactions based on the roles of the Notch ligands Jagged-1 and Delta-like-1. Overall, these studies demonstrate the spatial control of mechanotransduction-associated components, key growth factor and Notch signaling interactions, and point towards a possible role of E-Cadherin in translating intercellular mechanical gradients to downstream Notch signaling.
SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
Authors: Bertrand-Chapel Adrien , Caligaris Cassandre , Fenouil Tanguy , Savary Clara , Aires Sophie , Martel Sylvie , Huchedé Paul , Chassot Christelle , Chauvet Véronique , Cardot-Ruffino Victoire , Morel Anne-Pierre , Subtil Fabien , Mohkam Kayvan , Mabrut Jean-Yves , Tonon Laurie , Viari Alain , Cassier Philippe , Hervieu Valérie , Castets Marie , Mauviel Alain , Sentis Stéphanie , Bartholin Laurent 
Published: October 2022

AbstractTGF-β signaling is involved in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis, representing one of the four major pathways genetically altered in 100% of PDAC cases. TGF-β exerts complex and pleiotropic effects in cancers, notably via the activation of SMAD pathways, predominantly SMAD2/3/4. Though SMAD2 and 3 are rarely mutated in cancers, SMAD4 is lost in about 50% of PDAC, and the role of SMAD2/3 in a SMAD4-null context remains understudied. We herein provide evidence of a SMAD2/3 oncogenic effect in response to TGF-β1 in SMAD4-null human PDAC cancer cells. We report that inactivation of SMAD2/3 in SMAD4-negative PDAC cells compromises TGF-β-driven collective migration mediated by FAK and Rho/Rac signaling. Moreover, RNA-sequencing analyses highlight a TGF-β gene signature related to aggressiveness mediated by SMAD2/3 in the absence of SMAD4. Using a PDAC patient cohort, we reveal that SMAD4-negative tumors with high levels of phospho-SMAD2 are more aggressive and have a poorer prognosis. Thus, loss of SMAD4 tumor suppressive activity in PDAC leads to an oncogenic gain-of-function of SMAD2/3, and to the onset of associated deleterious effects.
Development of intensiometric indicators for visualizing N-cadherin interaction across cells
Authors: Kanadome Takashi , Hayashi Kanehiro , Seto Yusuke , Eiraku Mototsugu , Nakajima Kazunori , Nagai Takeharu , Matsuda Tomoki 
Published: October 2022

AbstractN-cadherin (NCad) is a classical cadherin that mediates cell–cell interactions in a Ca2+-dependent manner. NCad participates in various biological processes, from ontogenesis to higher brain functions, though the visualization of NCad interactions in living cells remains limited. Here, we present intensiometric NCad interaction indicators, named INCIDERs, that utilize dimerization-dependent fluorescent proteins. INCIDERs successfully visualize reversible NCad interactions across cells. Compared to FRET-based indicators, INCIDERs have a ~70-fold higher signal contrast, enabling clear identification of NCad interactions. In primary neuronal cells, NCad interactions are visualized between closely apposed processes. Furthermore, visualization of NCad interaction at cell adhesion sites in dense cell populations is achieved by two-photon microscopy. INCIDERs are useful tools in the spatiotemporal investigation of NCad interactions across cells; future research should evaluate the potential of INCIDERs in mapping complex three-dimensional architectures in multi-cellular systems.
Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity
Authors: Molla Md Rasel , Shimizu Akio , Komeno Masahiro , Rahman Nor Idayu A. , Soh Joanne Ern Chi , Nguyen Le Kim Chi , Khan Mahbubur Rahman , Tesega Wondwossen Wale , Chen Si , Pang Xiaoling , Tanaka-Okamoto Miki , Takashima Noriyuki , Sato Akira , Suzuki Tomoaki , Ogita Hisakazu 
Published: October 2022

AbstractWhether a small GTPase RhoA plays a role in the pathology of abdominal aortic aneurysm (AAA) has not been determined. We show here that RhoA expression is reduced in human AAA lesions, compared with normal areas. Furthermore, incidence of AAA formation is increased in vascular smooth muscle cell (VSMC)-specific RhoA conditional knockout (cKO) mice. The contractility of the aortic rings and VSMCs from RhoA cKO mice is reduced, and expression of genes related to the VSMC contractility is attenuated by loss of RhoA. RhoA depletion activates the mitogen-activated protein (MAP) kinase signaling, including MAP4K4, in the aorta and VSMCs. Inhibition of MAP4K4 activity by DMX-5804 decreases AAA formation. Set, a binding protein to active RhoA, functions as an activator of MAP4K4 by sequestering PP2A, an inhibitor of MAP4K4, in the absence of RhoA. In conclusion, RhoA counteracts AAA formation through inhibition of MAP4K4 in cooperation with Set.
Perspectives Relating to Multicultural Training With Speech-Language Pathologists
Authors: Hayes Evy J. , Mathews L. Amanda , Cloud Steven J. 
Published: October 2022

Purpose:
The goal of this project was to assess whether speech-language pathologists (SLPs) feel adequately prepared and comfortable interacting with multicultural clients. To determine whether an SLP feels prepared to interact with, to assess, to teach, or to treat a multicultural client, a 25-question survey was developed and administered.

Method:
The survey included questions pertaining to the SLPs' experiences with other cultures, both professional and personal, if the SLP speaks more than one language, and if the SLP has received any formal training on how to interact with multicultural clients. The survey was sent out via e-mail to 814 licensed SLPs practicing in preschool, elementary, and secondary school settings in Mississippi and Alabama. A total of 38 surveys were returned, and 36 complete responses were obtained.

Results:
Preliminary results indicated that many SLPs received minimal multicultural training and felt prepared to work with multicultural clients based on personal and professional experiences; however, they also believed that they could benefit from additional formal multicultural training.

Conclusions:
Surveyed SLPs do not report receiving adequate training for serving multicultural clients. Many reported that they would benefit from additional formal training in multiculturalism to better serve clients. Further research is indicated to determine the effectiveness of graduate-level training in multiculturalism.
Review of restoration technology for renewable‐dominated electric power systems
Authors: Chen Changming , Liang Hongle , Zhai Xingli , Zhang Jinai , Liu Shengyuan , Lin Zhenzhi , Yang Li 
Published: October 2022

AbstractWith the rapid development of renewable energy generation and multi‐energy system technologies, reviewing and discussing the emerging power system restoration methods and key technologies suitable for renewable‐dominated electric power systems and the Energy Internet are important. Based on this, the backgrounds of renewable‐dominated electric power systems and the Energy Internet are first introduced here. Subsequently, the power system restoration process is divided into three phases: the black‐start, network reconfiguration, and the load restoration phases; relative restoration strategy research on these three phases is reviewed. Moreover, the boundaries between these three phases are occasionally not sufficiently apparent or even cross in most cases owing to the severity of blackouts and other various factors. Therefore, the key technologies for power system restoration considering multiple phases are analysed in detail. Moreover, the major gaps between existing research and real‐world applications and the outlooks on the restoration technologies under renewable‐dominated electric power systems are discussed.
Distributed model predictive control strategy based on block‐wised alternating direction multiplier method for microgird clusters
Authors: Zhu Pengcheng , Liu Zhaoyu , Sun Ke , Wang Lei , Hu Pengfei , Zhu Naixuan , Jiang Daozhuo 
Published: October 2022

AbstractMicrogrid clusters (MGC) can improve the consumption of renewable energy and the system reliability. The control of microgrid cluster with large‐scale microgrids is the focus of microgrid cluster research. In order to better realize the coordination control and energy scheduling among microgrids, this paper proposes a distributed optimal strategy for complex MGC based on model predictive control (MPC) and block‐wised alternating direction multiplier method (BADMM). Firstly, an optimization model is established based on a honeycomb active distribution network (HADN); then the network is decomposed into several regions according to BADMM. The global optimization goal of the cluster is achieved by iterating the optimization results of each region in a time domain. Finally, the case study results verify the effectiveness and convergence of the proposed distributed optimization strategy, and provide a reference for energy management of MGC.
On the identification and assessment of underlying acoustic dimensions of soundscapes
Authors: Bergner Jakob , Peissig Jürgen 
Published: October 2022

The concept of soundscapes according to ISO 12913-1/-2/-3 proposes a descriptive framework based on a triangulation between the entities acoustic environment, person and context. While research on the person-related dimensions is well established, there is not yet complete agreement on the relevant indicators and dimensions for the pure description of acoustic environments. Therefore, this work attempts to identify acoustic dimensions that actually vary between different acoustic environments and thus can be used to characterize them. To this end, an exploratory, data-based approach was taken. A database of Ambisonics soundscape recordings (approx. 12.5 h) was first analyzed using a variety of signal-based acoustic indicators (Ni = 326) within the categories loudness, quality, spaciousness and time. Multivariate statistical methods were then applied to identify compound and interpretable acoustic dimensions. The interpretation of the results reveals 8 independent dimensions “Loudness”, “Directivity”, “Timbre”, “High-Frequency Timbre”, “Dynamic Range”, “High-Frequency Amplitude Modulation”, “Loudness Progression” and “Mid-High-Frequency Amplitude Modulation” to be statistically relevant. These derived latent acoustic dimensions explain 48.76% of the observed total variance and form a physical basis for the description of acoustic environments. Although all baseline indicators were selected for perceptual reasons, validation must be done through appropriate listening tests in future.
Association Of Blood Lipocalin-2 Levels with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis
Authors: Zhu Jing , Jiang Shuai , Jiang Xiaohong , Luo Kaiming , Huang Xiaolin , Hua Fei 
Published: October 2022

AbstractLipocalin-2 (LCN2) is becoming recognized as a pleiotropic mediator of metabolic disorders. However, the relationship between LCN2 and gestational diabetes mellitus (GDM) is not well understood. We performed a systematic review and meta-analysis to explore it. A systematic search of Cochrane Library, PubMed, Embase, Scopus, Web of Science, Chinese National Knowledge Infrastructure, and Wan-fang Database was done for relevant articles published up to September 29, 2021. Standardized mean difference (SMD) with 95% confidence intervals (CI) was calculated to explore the association of LCN2 levels with GDM using Revman 5.3 and Stata 15.1. Fifteen case-control studies were included in this meta-analysis. The patients with GDM had significantly higher levels of blood LCN2 than parturients with normal glucose tolerance (SMD=3.41, 95% CI=2.24 to 4.58). Meta-regression and subgroup analysis were conducted to investigate the source of heterogeneity. Likely sources of heterogeneity were age and testing methods. This study found that GDM showed higher blood LCN2 levels than controls. However, caution is warranted on the interpretation of these findings. Standardized LCN2 measurement methods and longitudinal studies are required to disentangle and better understand the relationships observed.
Easy Access to N-(Pyridin-2-yl)benzamides through Electro-oxidative Ring Opening of 2-Arylimidazo[1,2-a]pyridines
Authors: Ghosh Sayan , Dutta Jhilik , De Sarkar Suman , Halder Atreyee 
Published: October 2022

AbstractAn electro-oxidative method for the ring opening of imidazopyridine derivatives is reported. This mild protocol offers a sustainable alternative to the existing harsh reaction conditions and unleashes an efficient approach to produce N-(pyridin-2-yl)amide derivatives with good tolerance of different functional groups. Systematic mechanistic studies provided insight into the reaction pathway and revealed that the residual water of DMSO is the source of oxygen atoms in the products.
Reaction Mechanisms for Chiral-Phosphate-Catalyzed Transformations Involving Cationic Intermediates and Protic Nucleophiles
Authors: Reid Jolene P. , Zhai Jianyu 
Published: October 2022

AbstractRecent strategies for enantioinduction often focus on employing a chiral catalyst to noncovalently interact with the substrate. By restricting the number of low energy diastereomeric transition states the reacting components can adopt, stereoselectivity can be achieved. Many of these noncovalent interactions include a significant dispersive component and these types of contacts have historically been difficult to model accurately. Modern computational methods have been designed to overcome such limitations. Using our computational work on chiral phosphate catalysis, we discuss the reasons for enantioselectivity in diverse reaction space.1 Introduction2 Chiral Phosphate Catalysis3 Phosphate-Catalyzed Transfer Hydrogenation4 Phosphate-Catalyzed Aza-Friedel–Crafts Reaction5 Phosphate-Catalyzed Reactions Involving Allenamides6 Comprehensive Qualitative Models7 Chiral Phosphates and Thionium Intermediates8 Conclusion
Fronto-Temporo-Orbito-Zygomatic Approach with Orbital Reconstruction in Lesions causing Unilateral Non-pulsating Proptosis
Authors: Darwish Mohab , Moawad Ahmed 
Published: October 2022

Abstract
Background Unilateral non-pulsating proptosis can be caused by lesions with intraorbital extensions compressing the globe including sphenoid wing en plaque meningiomas and paranasal sinuses lesions.
Patients and Methods We operated on 20 patients with unilateral non-pulsating proptosis using fronto-temporo-orbito-zygomatic (FTOZ) approach with orbital reconstruction in six patients. Eighteen patients had sphenoid wing en plaque meningioma, 1 patient had paranasal sinuses fungal infection with intraorbital and intracranial extension, and 1 patient had frontal sinus dermoid with intraorbital extension.
Results Proptosis was corrected in 50% of the patients, improved in 25%, and remained stationary in 25%. Vision improved in three patients, remained stationary in three, and deteriorated in one patient. Two patients had temporary oculomotor ophthalmoplegia that resolved within 3 months.
Conclusion Although it is an invasive approach, FTOZ gives excellent exposure of the orbit and anterolateral skull base that allows the excision of intracranial lesions with orbital extension. If needed, the orbit could be reconstructed easily due to excellent exposure.
Use of Wrist Denervation in the Treatment of SLAC and SNAC Wrist by ASSH Members
Authors: Kale Nisha N. , Foote Jake , Medvedev Gleb 
Published: October 2022

Abstract
Background Scapholunate advanced collapse (SLAC) and scaphoid nonunion advanced collapse (SNAC) are common patterns of wrist arthritis, and surgical treatment options include partial and total wrist arthrodesis and wrist denervation, which maintains the current anatomy while relieving pain.
Introduction The purpose of this study is to elucidate current practices within the hand surgery community with respect to the use of anterior interosseous nerve/posterior interosseous nerve (AIN/PIN) denervation in the treatment of SLAC and SNAC wrists.
Methods An anonymous survey was distributed to 3,915 orthopaedic surgeons via the American Society for Surgery of the Hand (ASSH) listserv. The survey collected information on conservative and operative management, indications, complications, diagnostic block, and coding of wrist denervation.
Results In total, 298 answered the survey. 46.3% (N = 138) of the respondents used denervation of AIN/PIN for every SNAC stage, and 47.7% (N = 142) of the respondents used denervation of AIN/PIN for every SLAC wrist stage. AIN and PIN combined denervation was the most common standalone procedure (N = 185, 62.1%). Surgeons were more likely to offer the procedure (N = 133, 55.4%) if motion preservation had to be maximized (N = 154, 64.4%). The majority of surgeons did not consider loss of proprioception (N = 224, 84.2%) or diminished protective reflex (N = 246, 92.1%) to be significant complications. 33.5%, 90 respondents reported never performing a diagnostic block prior to denervation.
Conclusion Both SLAC and SNAC patterns of wrist arthritis can result in debilitating wrist pain. There is a wide range of treatment for different stages of disease. Further investigation is required to identify ideal candidates and evaluate long-term outcomes.
When health is wealth: occupationally differentiated patterns of health capital in post-industrial Europe
Authors: Harsløf Ivan , Larsen Kristian , Bambra Clare 
Published: October 2022

AbstractThis paper explores the general relationship between peoples’ health-related practices and their affiliation with different fields in the occupational structure. It argues that ‘healthy behaviour’ may be particularly induced in the field of service occupations (jobs where one is providing a service, rather than producing a physical product), rendering such practices an emerging capital in the sense advanced by Bourdieu. The paper presents an empirical elaboration of this theoretical argument by assessing comparative European data on health behavioural dispositions. Across occupational class levels, defined according to Esping-Andersen’s post-industrial class scheme, service workers display dispositions suggesting greater possessions of health capital than their counterparts in the industrial hierarchy. In a multilevel analysis, considering societal context, the paper furthermore associates such endowments with post-industrial development. Elaborating on the general relationships identified, we suggest the rising importance of individual health investments to be considered as potentially instigating and reinforcing symbolic boundaries (social closure).
Impact of social determinants on COVID-19 infections: a comprehensive study from Saudi Arabia governorates
Authors: Yaseen Abdallah S. A. 
Published: October 2022

AbstractThe last two years have been marked by the emergence of Coronavirus. The pandemic has spread in most countries, causing substantial changes all over the world. Many studies sought to analyze phenomena related to the pandemic from different perspectives. This study analyzes data from the governorates of the Kingdom of Saudi Arabia (the KSA), proposing a broad analysis that addresses three different research objectives. The first is to identify the main factors affecting the variations between KSA governorates in the cumulative number of COVID-19 infections. The study uses principal component regression. Results highlight the significant positive effects of the number of schools in each governorate, and classroom density within each school on the number of infections in the KSA. The second aim of this study is to use the number of COVID-19 infections, in addition to its significant predictors, to classify KSA governorates using the K-mean cluster method. Findings show that all KSA governorates can be grouped into two clusters. The first cluster includes 31 governorates that can be considered at greater risk of Covid infections as they have higher values in all the significant determinants of Covid infections. The last objective is to compare between traditional statistical methods and artificial intelligence techniques in predicting the future number of COVID-19 infections, with the aim of determining the method that provides the highest accuracy. Results also show that multilayer perceptron neural network outperforms others in forecasting the future number of COVID-19. Finally, the future number of infections for each cluster is predicted using multilayer perceptron neural network method.
Reconstructing makerspaces in China: mass innovation space and the transformative creative industries
Authors: Fu Pengfei , Li Lin , Xie Xuefang 
Published: October 2022

AbstractIn recent years, the makerspaces and so-called “mass innovation spaces” (MISs) in China have been under heavy scholarly investigation. However, despite the proliferation of MISs and growing interest in understanding this phenomenon, the definition of MIS has also been a concern in this field. Meanwhile, there has also been a tendency to link these reconstructed MISs with the development agenda of the local creative industries. What is an MIS, and how is it similar and different from the general understanding of makerspaces in the context of China? What can we learn from China’s adoption and appropriation of MISs in relation to the transformation of creative industries? To answer these questions, we conducted a semantic network analysis of the mission statements from 305 Chinese MISs. The results show that the Chinese MIS is quite different from the makerspace in terms of space, activities, values, philosophy, community, and organization. By examining the reconstructed MISs, this article provides some examples of how the Western, Californian ideology-centered concept of “makerspace” is repurposed as a new site with many alternative imaginaries that are interwoven with what we term “Shenzhen ideology”—a mix of socialism and technological determinism and a fusion of social conservatism and economic progressivism.