bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data-driven bus timetabling with spatial-temporal travel time
Authors: Li Xiang , Yang Ming , Ma Hongguang , Yu Kaitao (Stella) 
Published: January 2022

PurposeTravel time at inter-stops is a set of important parameters in bus timetabling, which is usually assumed to be normal (log-normal) random variable in literature. With the development of digital technology and big data analytics ability in the bus industry, practitioners prefer to generate deterministic travel time based on the on-board GPS data under maximum probability rule and mean value rule, which simplifies the optimization procedure, but performs poorly in the timetabling practice due to the loss of uncertain nature on travel time. The purpose of this study is to propose a GPS-data-driven bus timetabling approach with consideration of the spatial-temporal characteristic of travel time.Design/methodology/approachThe authors illustrate that the real-life on-board GPS data does not support the hypothesis of normal (log-normal) distribution on travel time at inter-stops, thereby formulating the travel time as a scenario-based spatial-temporal matrix, where K-means clustering approach is utilized to identify the scenarios of spatial-temporal travel time from daily observation data. A scenario-based robust timetabling model is finally proposed to maximize the expected profit of the bus carrier. The authors introduce a set of binary variables to transform the robust model into an integer linear programming model, and speed up the solving process by solution space compression, such that the optimal timetable can be well solved by CPLEX.FindingsCase studies based on the Beijing bus line 628 are given to demonstrate the efficiency of the proposed methodology. The results illustrate that: (1) the scenario-based robust model could increase the expected profits by 15.8% compared with the maximum probability model; (2) the scenario-based robust model could increase the expected profit by 30.74% compared with the mean value model; (3) the solution space compression approach could effectively shorten the computing time by 97%.Originality/valueThis study proposes a scenario-based robust bus timetabling approach driven by GPS data, which significantly improves the practicality and optimality of timetable, and proves the importance of big data analytics in improving public transport operations management.
Finite-element modeling of partially prestressed concrete beams with unbonded tendon under monotonic loadings
Authors: Pandimani  , Ponnada Markandeya Raju , Geddada Yesuratnam 
Published: January 2022

Purpose
The partially prestressed concrete beam with unbonded tendon is still an active field of research because of the difficulty in analyzing and understanding its behavior. The finite-element (FE) simulation of such beams using numerical software is very scarce in the literature and therefore this study is taken to demonstrate the modeling aspects of unbonded partially prestressed concrete (UPPSC) beams. This study aims to present the three-dimensional (3-D) nonlinear FE simulations of UPPSC beams subjected to monotonic static loadings using the numerical analysis package ANSYS.

Design/methodology/approach
The sensitivity study is carried out with three different mesh densities to obtain the optimum elements that reflect on the load–deflection behavior of numerical models, and the model with optimum element density is used further to model all the UPPSC beams in this study. Three half-symmetry FE model is constructed in ANSYS parametric design language domain with proper boundary conditions at the symmetry plane and support to achieve the same response as that of the full-scale experimental beam available in the literature. The linear and nonlinear material behavior of prestressing tendon and conventional steel reinforcements, concrete and anchorage and loading plates are modeled using link180, solid65 and solid185 elements, respectively. The Newton–Raphson iteration method is used to solve the nonlinear solution of the FE models.

Findings
The evolution of concrete cracking at critical loadings, yielding of nonprestressed steel reinforcements, stress increment in the prestressing tendon, stresses in concrete elements and the complete load–deflection behavior of the UPPSC beams are well predicted by the proposed FE model. The maximum discrepancy of ultimate moments and deflections of the validated FE models exhibit 13% and −5%, respectively, in comparison with the experimental results.

Practical implications
The FE analysis of UPPSC beams is done using ANSYS software, which is a versatile tool in contrast to the experimental testing to study the stress increments in the unbonded tendons and assess the complete nonlinear response of partially prestressed concrete beams. The validated numerical model and the techniques presented in this study can be readily used to explore the parametric analysis of UPPSC beams.

Originality/value
The developed model is capable of predicting the strength and nonlinear behavior of UPPSC beams with reasonable accuracy. The load–deflection plot captured by the FE model is corroborated with the experimental data existing in the literature and the FE results exhibit good agreement against the experimentally tested beams, which expresses the practicability of using FE analysis for the nonlinear response of UPPSC beams using ANSYS software.
Supply chain capital and firm performance: the role of complementary capabilities
Authors: Wang Chunhsien , Chin Tachia , Ting Chung-Te 
Published: January 2022

PurposeDrawing on social capital theory, we extend the concept of supply chain capital to examine whether structural and relational capital can strengthen the complementary capabilities of suppliers and enhance their performance.Design/methodology/approachThe empirical study was conducted on 161 precision mold equipment suppliers. To evaluate the mediated moderation model of supply chain capital, we applied multiple linear regression to test our hypotheses.FindingsWe found that both structural and relational capital positively affect the complementary capabilities of suppliers and that these capabilities mediate the relationship between supply chain capital and supplier performance. Furthermore, structural capital positively and significantly moderates the mediating effect on the relationship between complementary capabilities and supplier performance.Research limitations/implicationsThis study provides suggestions for suppliers that are equipped with sufficient structural and relational capital to effectively enhance their complementary capabilities. By considering the interaction between structural capital and complementary capabilities, suppliers can effectively improve their performance.Originality/valueThis novel research develops a theoretical model to examine the antecedents and consequences of supplier complementary capabilities. We contribute to a new line of research on supply chain capital, which aims to explore how it affects the complementary capabilities of suppliers by examining a practical supply chain activity setting.
Lessons from the COVID epicenter: how teacher candidates of color and the academy adapted to remote instruction
Authors: Magaldi Danielle , Fayne Harriet 
Published: January 2022

Purpose
Given the challenges of remote learning and the pandemic’s disproportionate impact on communities of color, this paper aims to present the voices of teacher candidates of color working on the frontlines of remote learning in communities of color hard-hit by the pandemic and to understand changes made in the shift to remote instruction for teacher education at the university level.

Design/methodology/approach
Two teacher candidate narratives are presented as case studies along with findings from a self-study on the changes necessitated by remote instruction in two teacher preparation courses at the university level.

Findings
Findings underscore teacher candidates’ fortitude amidst compound stress. Emergent themes included flexibility, adapting, reaching out for help, problem-solving and drawing on their own experiences. Themes also included struggle, fatigue and feelings of incompetence. At the university level, teacher education preparation required flexibility and opening up space for collaborative problem-solving.

Originality
In urban communities of color, pre-pandemic disparities in under-resourced public schools not only persisted but were intensified by the pandemic’s unequal impact on people of color. This study foregrounds the voices and experiences of teacher candidates of color teaching remotely, providing contributions to the field derived from their lived experiences. Their voices are essential data, bringing much needed attention to obstacles of remote teaching in communities of color and to the resourcefulness teacher candidates demonstrated in service of multicultural education.
Corporate social responsibility and systematic risk: international evidence
Authors: Dorfleitner Gregor , Grebler Johannes 
Published: January 2022

PurposeThis paper aims to close gaps in the current literature according to whether there are differences regarding the relationship between corporate social performance (CSP) and systematic risk when diverse regions of the world are considered, and what the respective drivers for this relationship are. Furthermore, it tests the robustness to alternative measures for CSP and systematic risk.Design/methodology/approachThis study focuses on the impact of corporate social responsibility on systematic firm risk in an international sample. The authors measure CSP emerging from a company's social responsibility efforts by utilizing a CSP rating framework that covers a variety of dimensions. The instrumental variable approach is applied to mitigate endogeneity and identify causal relationships.FindingsThe impact of overall CSP on systematic risk is most distinct for North American firms and, in descending order, weaker in Europe, Asia–Pacific and Japan. Risk mitigation applies across all four regions. However, the magnitude of impact differs. While the most critical drivers in North America and Japan include product responsibility, Europe is affected most by the employees category and Asia–Pacific by environmental innovation.Practical implicationsThe findings help firms to control their cost of equity and investors may identify low-risk stocks by considering certain aspects of CSP.Originality/valueThis study distinguishes itself from previous literature addressing the connection between systematic risk and CSP by focusing on regional differences in an international sample, using the very transparent CSP measures of Asset4, identifying underlying impact drivers, and testing for robustness to alternative measures of systematic risk.
Adverse childhood experiences are associated with increased risk of hysterectomy and bilateral oophorectomy: A national retrospective cohort study of women in England
Authors: Demakakos Panayotes , Steptoe Andrew , Mishra Gita D. 
Published: January 2022

AbstractObjectiveTo examine the associations between adverse childhood experiences (ACE) and the risk of hysterectomy and bilateral oophorectomy in a national sample of women in England.DesignRetrospective cohort study.SettingA stratified random sample of households across England.Population2648 women aged ≥55 years in 2007 from the English Longitudinal Study of Ageing (ELSA) were included in the bilateral oophorectomy analyses and 2622 in the hysterectomy analyses.MethodsLogistic and multinomial logistic regression analyses of the associations between categories of the ACE summary score (0, 1, 2, ≥3 ACE), eight individual ACE, and hysterectomy and bilateral oophorectomy.Results615 women had undergone hysterectomy and 259 women bilateral oophorectomy. We found graded associations between the summary ACE score and risk of hysterectomy and bilateral oophorectomy. In the fully adjusted model, compared with women with no ACE, those with ≥3 ACE had double the odds of hysterectomy (odds ratio [OR] 2.01, 95% confidence interval [CI] 1.30–3.11) and more than double the odds of bilateral oophorectomy (OR 2.61, 95% CI 1.54–4.42). The exclusion of women with cancer history made the associations stronger, especially in women who underwent hysterectomy at age <40 years or bilateral oophorectomy at age ≤44 years. Several individual ACE were positively associated with both outcomes.ConclusionsACE are associated with increased risk of hysterectomy and bilateral oophorectomy. Individual‐level covariates did not explain these associations. Our findings highlight the importance of a life course approach to understanding surgical menopause and add to our knowledge of the societal and public health impact of ACE.Tweetable abstractAdverse childhood experiences are associated with increased risk of hysterectomy and bilateral oophorectomy in a national sample of women in England.
Lethal giant larvae gene is required for normal nymphal development and midgut morphogenesis in Locusta migratoria
Authors: Shi Xuekai , Liu Xiaojian , Silver Kristopher , Zhu Kun Yan , Zhang Jianzhen 
Published: January 2022

AbstractDisruption of morphogenesis, an essential process in organismal development, can lead to disruption of biological processes, reduction in fitness, or even death of an organism. The roles of lethal giant larvae (Lgl) protein in maintaining tissue organization have been studied extensively in mammals, but little is known about this gene's roles in promoting correct tissue morphogenesis in insects. In this study, we identified an Lgl ortholog in Locusta migratoria. RT‐qPCR results revealed that LmLgl was constitutively expressed during third, fourth, and fifth instar nymphs. Furthermore, LmLgl showed highest expression in the ovary followed by wing pads, midgut, hindgut, Malpighian tubules, and foregut of the third‐instar nymphs. To examine the role of LmLgl in L. migratoria development, RNA interference was performed during nymphal stages. Silencing of LmLgl increased body size but decreased bodyweight by 9.0%. Histological sections of the midgut revealed abnormal large masses of disordered epithelial cells in dsLmLgl‐injected nymphs. In addition, downregulation of LmLgl transcript levels significantly altered the morphological structure in midgut, resulting in the formation of tumor‐like structures. Our results indicated that LmLgl may act as a tumor‐suppressor gene, which plays an essential role in maintaining a normal morphological structure in the midgut of L. migratoria. Our results also suggest that LmLgl may be explored as a potential target for developing dsRNA‐based biological pesticides for managing insect pests.
Early experience of COVID‐19 vaccine‐related adverse events among adolescents and young adults with rheumatic diseases: A single‐center study
Authors: Haslak Fatih , Gunalp Aybuke , Cebi Memnune Nur , Yildiz Mehmet , Adrovic Amra , Sahin Sezgin , Barut Kenan , Kasapcopur Ozgur 
Published: January 2022

AbstractObjectiveConsidering the concerns regarding the coronavirus disease‐2019 (COVID‐19) vaccine safety among pediatric patients with inflammatory rheumatic diseases (IRD) due to a lack of data, an urgent need for studies evaluating safety profiles of vaccines emerged.MethodsAmong participants vaccinated by CoronaVac inactive SARS‐CoV‐2 or BNT162b2 messenger RNA (mRNA) COVID‐19 (Pfizer‐BioNTech) vaccine, healthy children under 18 and patients under 21 with an at least 1‐year follow‐up period in our department for a childhood‐onset rheumatic disease were included into this cross‐sectional study.ResultsOverall, 246 subjects (141 [57.3%] females) (biologic group: 43, non‐biologic group: 180, healthy control group: 23) were eligible for the study. The median age was 15.34 (12.02‐20.92) years. The most common adverse events were fatigue (n = 68, 27.6%), headache (n = 44, 17.9%), myalgia (n = 38, 15.4%), arthralgia (n = 38, 15.4%), and fever (n = 35, 14.2%). Only 3 subjects (2 patients with familial Mediterranean fever, and one healthy child) were considered to experienced serious adverse events, since they required hospitalization. Local reactions were seen in 20 (8.13%), and 27 patients (12.1%) had disease flares within 1 month after the vaccines. Although it was significantly higher in those who received the BNT162b2 mRNA vaccine (P < .001), there was no significant relationship between adverse event frequency and age, gender, the existing diseases, ongoing treatment regimens and pre‐vaccination COVID‐19 histories.ConclusionAlthough immunogenicity studies for efficacy of the vaccines and long‐term follow‐up studies for adverse events monitoring are required, our study indicates an acceptable safety profile of COVID‐19 vaccines and encourages children with IRD to be vaccinated.
Early detection of HVAD pump thrombosis based on technical analysis and power consumption measurements
Authors: Krysiński Mateusz , Gawlikowski Maciej , Biełka Agnieszka , Krysińska Małgorzata , Małyszek‐Tumidajewicz Justyna , Copik Izabela , Pacholewicz Jerzy , Zembala Marian , Zembala Michał 
Published: January 2022

AbstractBackgroundContinuous‐flow left ventricular assist devices (LVADs) have been extensively used in a strategy of bridge to orthotopic heart transplant and destination therapy. The usage of LVAD, however, is not free from limitations such as device‐related adverse events, including pump thrombosis (PT). We aimed to develop an algorithm of early PT detection based on the maintenance parameters monitored by the implanted device.MethodsWe analyzed log files of 101 patients implanted with HeartWare pump (HVAD) with 18 PT events among them. For signal processing, we used the open‐high‐low‐close format transformation and typical price (TP) technical analysis indicator. Model parameters were tuned with 5‐fold cross‐validation, and the final performance was measured on a separate group of patients.ResultsOur algorithm achieved 100% sensitivity and 100% specificity of indications. In the final evaluation, alarms preceded the clinical acknowledgement of events by 2 days and 20 h on average. In the worst‐case scenario, an alarm was raised 1 day and 8 h prior to the event.ConclusionsThe proposed algorithm could be installed to work directly with the device controller and provide clinicians with automatic readings analysis, raising an alarm when there is a high probability of thromboembolism. Early event detection could enable better thrombosis management and improve prognosis in patients implanted with HVAD.
Aryl hydrocarbon receptor (AhR) activation contributes to high‐fat diet‐induced vascular dysfunction
Authors: da Silva Josiane Fernandes , Bolsoni Juliana A. , da Costa Rafael M. , Alves Juliano V. , Bressan Alecsander F. M. , Silva Luiz Eduardo V. , Costa Tiago J. , Oliveira Antonio E. R. , Manzato Carla P. , Aguiar Carlos A. , Fazan Rubens , Cunha Fernando Q. , Nakaya Helder I. , Carneiro Fernando S. , Tostes Rita C. 
Published: January 2022

Background and PurposeMetabolic and vascular dysfunction are common features of obesity. Aryl hydrocarbon receptor (AhR) regulates lipid metabolism and vascular homeostasis, but whether vascular AhR are activated in obesity or have a protective and/or harmful effects on vascular function in obesity are unknown. Our study addresses whether AhR activation contributes to obesity‐associated vascular dysfunction and the mechanisms involved in these AhR effects.Experimental ApproachMale AhR KO (Ahr−/−) and WT mice were fed either control or a HF (high‐fat) diet for 10 weeks. Metabolic and inflammatory parameters were measured in serum and adipose tissue. Vascular reactivity (isometric force) was evaluated using a myography. Endothelial NOS (eNOS) and AhR protein expression was determined by western blot, Cyp1A1 and Nos3 gene expression by RT‐PCR and.NO production was quantified by DAF fluorescence.Key ResultsHF diet increased total serum HDL and LDL, as well as vascular AhR protein expression and proinflammatory cytokines in the adipose tissue. HF diet decreased endothelium‐dependent vasodilation. AhR deletion protected mice from HF diet‐induced dyslipidaemia, weight gain and inflammatory processes. HF diet‐induced endothelial dysfunction was attenuated in Ahr−/− mice. Vessels from Ahr−/− mice exhibited a greater NO reserve. In cultured endothelial cells, lysophosphatidylcholine (LPC) a major component of LDL and oxidized LDL [oxLDL]) reduced Nos3 gene expression and NO production. Antagonism of the AhR inhibited LPC effects on endothelial cells and induced decreased endothelium‐dependent vasodilation.Conclusion and ImplicationsAhR deletion attenuates HF diet‐induced dyslipidaemia and vascular dysfunction by improving eNOS/NO signalling. Targeting AhRs may prevent obesity‐associated vascular dysfunction.
Provenance and maximum depositional ages of Upper Triassic and Jurassic sandstone, north‐eastern Mexico
Authors: Martin Aaron J. , Domènech Mireia , Stockli Daniel F. , Gómez‐Gras David 
Published: January 2022

AbstractUpper Triassic to lowest Upper Jurassic strata in north‐eastern Mexico record surface processes during the early rifting that led to the opening of the Gulf of Mexico. Exposed near Ciudad Victoria, Tamaulipas and northwest to Galeana, Nuevo Leon, these continental deposits are called the Huizachal Group. Several key questions about these strata hamper their integration into a regional understanding of Late Triassic and Jurassic sediment routing and deposition. First, the depositional age of the stratigraphically lowest unit, the El Alamar Formation, is less well established than the depositional ages of the stratigraphically higher parts of the succession, leading to questions about the timinig of the onset of tectonic context, and regional correlation of these strata. Second, better knowledge of provenance and sediment routing, including fluvial transport distance, can help determine whether and when the depositional basin was split into subbasins versus connected by a throughgoing river system. This study uses sandstone detrital zircon U‐Pb isotopic ages and clast compositions to constrain depositional ages and reconstruct tectonic setting and provenance. Detrital zircon U‐Pb ages yielded a maximum depositional age of 210 Ma for the part of the El Alamar Formation exposed near Galeana, younger than previously determined. Although long‐distance (>100 km) sediment transport cannot be ruled out, the sources for Huizachal Group sandstone framework grains and detrital zircon could have been entirely local, within about 100 km. Alluvial deposits and pyroclastic and lava flows likewise indicate transport of no more than 100 km. We therefore infer deposition in partitioned rift basins receiving sediment from local sources. These data and interpretations contribute to understanding surface processes during the initial rifting that eventually led to opening of the Gulf of Mexico.