bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organic–inorganic hybrid perovskite [NH 3 (CH 2 ) 5 NH 3 ]ZnCl 4 crystal: growth, structure, phase transition, thermal properties, and structural dynamics
Authors: Lim Ae Ran , Cho Jiung 
Published: June 2022

Abstract
In this study, the physicochemical properties of [NH3(CH2)5NH3]ZnCl4 crystals were investigated using X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and nuclear magnetic resonance (NMR). The crystals had a monoclinic structure with C2/c space group and lattice constants are a=21.4175 Å, b=7.3574 Å, c=19.1079 Å, β=120.5190°, and Z=8. Phase-transition temperatures in the DSC curve were 256 K, 390 K, and 481 K. Additionally, a small change near 340 K, related to phase transition, was observed in the XRD pattern. NMR studies indicated no change in 1H chemical shifts, but a change in the chemical shifts for C2, located between C1 and C3 of the cation at 340 K. Increase in molecular motion caused an increase in the spin-lattice relaxation time, T1ρ, at low spinning rates, under magic-angle spinning (MAS) rate conditions. The inorganic anion was composed of octahedral BCl6, when the metal ion (B) was Mn, Cu, and Cd, and tetrahedral BCl4, when B was Zn and Co. The coordination geometries of BCl6 and BCl4, connected by N−H∙∙∙Cl hydrogen bonds between Cl and the organic cation, were investigated.
Considerations on the Origin of the Inferior Thyroid Artery Emerging from the Subclavian Artery Determined by Ct Examination
Authors: Bunea Maria Cristina , Rusali Lavinia Maria , Bratu Iulian Cătălin , Tudorache Sorin , Bordei Petru 
Published: June 2022

Abstract
The specialized literature has a low degree of information regarding the origin of the ITA. The study was performed on computed tomography angiographies (CTAs), and the following aspects were observed: the origin of the ITA from the SCA or TCT, taking note of the distance of the origin of the ITA in relation to the origin of the SCA or the corresponding TCT, as well as the origin of the ITA, comparing right to left and according to gender.Our study was realized on a total of 108 ITA (64 on the right side and 44 on the left, with 48 in male subjects and 60 in females), analyzed on CTA.From the 108 arteries, we found the origin of ITA directly from the SCA in 31.48% of cases, and in 68.52% from the TCT. The distance between the origin of the right SCA and the origin of the corresponding ITA, was between 29.1 – 53.1 mm, while on the left side, the same distance was between 43.7 – 68.1 mm. The distance between the right TCT and the origin of the right SCA, was between 22.5 – 75.0 mm, and for the left side, it’s between 48.7 – 56.8 mm.The inferior thyroid artery is one of the arteries most susceptible to variations in terms of origin and size. With differences between the two sides (right and left), as well as differences related to gender
Sarcopenia does not affect treatment outcomes in patients with rectal cancer undergoing laparoscopic surgery
Authors: Song Ji Hyeong , Oh Rak Kyun , Lee Jeong Eun , Lee Kyung Ha , Kim Ji Yeon , Kim Jin Soo 
Published: June 2022

Abstract
Purpose
Previous studies have reported that sarcopenia negatively impacts rectal cancer treatment. However, most published studies have analyzed only patients undergoing open surgery, and the association between sarcopenia and clinical outcomes in patients with rectal cancer undergoing laparoscopic surgery remains unclear. This study aimed to evaluate the effect of sarcopenia on the clinical and oncological outcomes of laparoscopic rectal cancer surgery.
Methods
Three hundred and one patients undergoing laparoscopic rectal cancer surgery were enrolled between December 2009 and May 2016. Body composition was assessed using computed tomography by measuring the muscle and fat areas at the third lumbar (L3) vertebra. The L3 skeletal muscle area was used to calculate the skeletal muscle index and evaluate sarcopenia.
Results
Sarcopenia was identified in 72/301 (23.9%) patients. Patients with sarcopenia had decreased skeletal muscle area (P < 0.001). However, there were no significant differences in visceral fat, subcutaneous fat, and body mass index. The time to tolerable soft diet and length of hospital stay were shorter in sarcopenia patients. The time to first flatus, postoperative complications, and overall and disease-free survival rates were not significantly different between those with and without sarcopenia. High American Society of Anesthesiologist classification (≥ 3; P = 0.014) and abdominoperineal resection (P = 0.003) were identified as risk factors for postoperative complications.
Conclusion
Sarcopenia does not negatively affect the functional recovery, postoperative complications, or survival after laparoscopic rectal cancer surgery. Further studies are necessary to validate that laparoscopic surgery could eliminate the negative impact of sarcopenia in patients with rectal cancer.
Counter-clockwise metamorphic P-T paths from Botnnuten in the southern Lützow-Holm Complex, East Antarctica
Authors: Baba Sotaro , Ohshiro Seira , Kamei Atsushi , Hokada Tomokazu , Kitano Ippei 
Published: June 2022

Abstract
This paper reports the metamorphic texture of cordierite megacrysts and the metamorphic P–T path of a newly exposed section of gneiss in East Antarctica. We used mineral textures and pseudosection modeling to reconstruct the metamorphic P–T path of cordierite- and spinel–garnet-bearing gneisses from Botnnuten, an isolated nunatak located ~ 60 km from the southern edge of Lützow–Holm Bay in East Antarctica. The gneisses underwent granulite-facies metamorphism with a counter-clockwise P–T path. This contrasts with the widely recognized clockwise P–T path of basement rocks of the Lützow–Holm Complex. The rocks at Botnnuten have long been considered part of the Lützow–Holm Complex based on their petrographical features and geothermobarometric data. However, the present results, combined with a reevaluation of available data, indicate the metamorphic history of the Botnnuten gneisses is more comparable to that of the Yamato Mountains, located west of the study area.
Regional Quantification of Bleomycin-Induced Pulmonary Fibrosis in Mice by Microcomputed Tomography for the Assessment of the Therapeutic Responses of Antifibrotic Drugs
Authors: Lai Ruogu , Zhao Caiping , Guo Wanyi , Xiao Yao , Li Runze , Liu Liang , Pan Hudan 
Published: June 2022

Abstract
Idiopathic pulmonary fibrosis is a serious, progressive, and fatal lung disorder. Microcomputed tomography (micro-CT) is a powerful technology for drug development that can be used to monitor the progression of lung fibrosis in animal model. However, the current analysis methods for quantifying micro-CT image require time and experiences to analyze CT data in detail by radiologists. Here, a self-controlled extracted subvolume histogram analysis (SEHA) method was developed to assess the development of pulmonary fibrosis easily.Method: The SEHA method consisted of five steps: in vivo micro-CT imaging with fixed posture, image reconstruction, subvolume extraction, histogram analysis, and scan comparison before or after treatment. The robustness, repeatability, and accuracy of SEHA were validated.Results: The sites of fibrosis in 66 bleomycin (BLM)-induced pulmonary fibrosis mice were variable but generally occurred in the middle and upper lungs. In validation of the accuracy and robustness of SEHA, the percentage of high-density voxels in selected volumes of interest (VOIs) was well correlated with that from whole-lung analysis both at Day 7 and Day 21 after bleomycin administration (R2= 0.8784 and 0.8464, respectively; P<0.0001). In validation of the repeatability of SEHA, the relative standard deviation (RSD) of the percentage of high-density voxels in the VOIs was significantly less than that of whole-lung analysis (1.645±1.884% VS 3.501±1.637%, P=0.0282). In validation of the radiographic and histological accuracy of SEHA, there was a good correlation between micro-CT and histological analysis both in the early and late stages of fibrosis (R2= 0.7434 and 0.7573, respectively; P<0.0001).Conclusion: SEHA is a straight forward method for quantifying pulmonary fibrosis and facilitate for primary micro-CT data analyzer.
Restoring miR-145 overcome oxaliplatin resistance by targeting the ABCC1 gene and re-establishing drug-induced anti-cancer effects in colorectal cancer
Authors: Sadeghzadeh Mahsa , Asadi Milad , Baradaran Behzad , Zafari Venus , Bornehdeli Soghra , Khani Haniye Mohammad Reza , Zarredar Habib , Shanehbandi Dariush , Mansoori Behzad 
Published: June 2022

Abstract
Drug resistance limits the effectiveness of chemotherapy in colorectal cancer (CRC). Consequently, finding appropriate strategies for re-sensitizing chemo-resistant cells is crucial. Our present study aimed at taking advantage of chemotherapy and gene therapy by restoring microRNA-145 expression in oxaliplatin resistant CRC cells. Bioinformatic analysis of clinical colorectal cancer tissue revealed that miR-145 levels were significantly lower than in adjusted tumors. Afterward, pCMV-miR-145 vectors were transfected into the oxaliplatin-resistant SW-480 CRC cells. Using miR-145 and Oxaliplatin together to treat Oxaliplatin-resistant cells, the results showed significant differences in viability, proliferation, apoptosis and migration compared to the individual treatments. Furthermore, miRNA prediction results as well as mRNA and protein expression indicated that miR-145 targeted ABCC1. Also, mRNA expression analysis was performed to evaluate a panel of genes involved in cell viability, apoptosis, motility, and drug resistance. These genes included K-ras, Bcl2, CASP3, -8, -9, MMP13, MDR-1, and ABCC1. These expression changes tended towards apoptosis induction and decreased proliferation and migration. Based on our findings, miR-145 restoration via decreasing the drug resistance biomarkers ABBCC1 and MDR1, along with other oncogenes such as K-Ras and Bcl2, and increasing apoptosis conductores could sensitize oxaliplatin-resistant cells to chemotherapy.
Development and Validation of the NYFT for Family Triage
Authors: Gradussen Maria , Tonnaer Franca , Delsing Marc , Scholte Ron , Cima Maaike 
Published: June 2022

Abstract
Adolescents and their families should receive the appropriate support at the right time, based on their strengths, risk factors and needs. However, comprehensive instruments to determine these characteristics seem generally lacking. In the current study we aim to develop a family triage instrument, assessing the necessary level and type of care. This Needs of Youth and Family Triage (NYFT) assessment includes all relevant individual factors, familial characteristics and environmental characteristics. The current study reports the psychometric properties of the NYFT in a validation study based on two samples: adolescents from secure residential youth care institutions (n = 65) versus a non-clinical control group of adolescents recruited from two secondary schools (n = 67). Factor analyses yielded a three-factor solution: 1. Authoritative Parenting/Positive Family Climate; 2. Adolescent (Social) Functioning; 3. Adolescent Well-being and Participation. Results showed that the NYFT had satisfactory reliability and convergent validity, along with an excellent discriminant validity. In conclusion, the NYFT is a promising triage instrument providing advice on the level and type of care (or help) needed, so that the right care can be offered immediately.
Differential Uridyl-diphosphate-Glucuronosyl Transferase 1A enzymatic arsenal explains the specific cytotoxicity of resveratrol towards tumor colorectal cells
Authors: Amintas Samuel , Beaumont Pauline , Dupin Charles , moranvillier isabelle , Lamrissi Isabelle , Patel Elie , Fernandez Benjamin , Bibeyran alice , Boutin Julian , Richard Tristan , Krisa Stéphanie , Moreau-Gaudry François , Bedel Aurelie , Cappellen David , Pinson Benoit , Vendrely Véronique , Dabernat Sandrine 
Published: June 2022

Abstract

Resveratrol belongs to the Bioactive Food Component (BFC) family. It seems admitted that its cytotoxic action impacts tumor cells and spares healthy cells, but the published proofs remain rare. We hypothesized that cells may differentially metabolize resveratrol and lead to different systemic impacts. For this, resveratrol metabolization was evaluated by ultra-high-performance liquid chromatography (UHPLC) coupled with diode array detection (DAD), and correlated with the expression of Uridyl-diphosphate-Glucuronosyl Transferase 1A (UGT1A) genes. The expression of UGT1A genes in human colorectal tissues was studied with RNAseq databases. Functional validation of UGT1A enzymes implication in resveratrol sensitivity of colorectal cells established by UGT1A expression modulation. As resveratrol impacts the S phase of the cell cycle, nucleotide metabolic balance was assessed. We found that resveratrol was more cytotoxic in cells with downregulation of UGTs, i.e. tumor cells. Conversely, overexpression of the UGT1A10 gene in an initial resveratrol-sensitive tumor cell line restored the metabolization accompanied by cytotoxicity diminution. Resveratrol affected intestinal sensitive tumor cell homeostasis with a cell growth/proliferation decoupling, cell-cycle modulation, and UXP/AXP nucleotide imbalance resulting in a global reduction of transcription and translation. This impact on global cell activity was restricted to tumor cells. This study improves resveratrol’s general knowledge and explains how its antitumor action can spare non-tumor cells. It also paves the way to select colorectal tumors eligible for resveratrol treatment potentiation without additional toxicity to healthy digestive tissues.
“Obstetrical dilemma” in viviparous snails
Authors: Sulikowska-Drozd A. , Maltz T.K. , Janiszewska K. 
Published: June 2022

Abstract
Viviparous gastropods keep embryos within their genital tract, hidden as the whole soft body, within a parental shell. Consequently, during birth, shelled offspring pass through the aperture of the parental shell, which results in a trade-off between the dimensions of the aperture and the embryo size. The mechanical obstacles involved in this process mirror the selection of obstetrics experienced by humans, as well as the pelvic constraints recorded in other tetrapods. The repeated evolution of viviparity in Clausiliidae, the family of land snails, which produce complex apertural barriers, gave us the opportunity to explore different ways of overcoming this evolutionary conflict. Most viviparous species are adapted by broadening of the shell canal and/or reduction of embryonic width. Some species reduce apertural barriers to the extent that they are no longer functional, whilst others produce unusual flexible, “soft shelled” embryos. The latter adaptation, recorded here for the first time, allows to overcome the “obstetrical dilemma” with minimal change in the outline of the adult shell and apertural barriers. The thickness and organomineral structure of flexible embryonic shells were investigated, compared to the typical “hard” shell of clausiliid embryos, which are rigid and unpliable already in the genital tract of the parent.
Morphometric classification of kangaroo bones reveals paleoecological change in northwest Australia during the terminal Pleistocene
Authors: Mein Erin , Manne Tiina , Veth Peter , Weisbecker Vera 
Published: June 2022

Abstract
Specimen identification is the backbone of archeozoological research. The challenge of differentiating postcranial skeletal elements of closely related wild animals in biodiverse regions can prove a barrier to understanding past human foraging behaviours. Morphometrics are increasingly being employed to classify paleozoological animal remains, however, the potential of these methods to discriminate between wild animal groups has yet to be fully realised. Here we demonstrate the applicability of a traditional morphometric approach to taxonomically classify foot and ankle bones of kangaroos, a large and highly diverse marsupial family. Using multiple discriminant analysis, we classify archaeological specimens from Boodie Cave, in northwest Australia and identify the presence of two locally extinct macropod species during the terminal Pleistocene. The appearance of the banded hare-wallaby and northern nail-tail wallaby in the Pilbara region at this time provides independent evidence of the ecological and human responses to a changing climate at the end of the last Ice Age. Traditional morphometrics provides an accessible, inexpensive, and non-destructive tool for paleozoological specimen classification and has substantial potential for applications to other diverse wild faunas.
Evaluation of the incidence and severity of peacock eye caused by Fusicladium oleagineum in different olive cultivars in Algeria
Authors: KHEDDAM-BENADJAL Nadia , BENZAHRA Abdelmajid , KHEDDAM Mohamed , BOUZNAD Zouaoui 
Published: June 2022

Abstract
The peacock's eye of the olive tree is a very feared disease in orchards of susceptible varieties, especially in the affected olive growing regions of the West and the Center of Algeria. Eleven olive (Olea europaea L.) cultivars including Chemlal, Sylviane, Rougette, Limli, Sigoise, Bounguergueb, Cœur de bœuf, Zaîti, Khodeiri, Terrella and Sorani, were studied for their susceptibility to Fusicladium oleagineum, the causal agent of peacock's eye disease on olive tree in Algeria. Investigations were carried out during the periods of risk of contamination: one in spring and the other in autumn or autumn to winter to measure the incidence and severity of the disease in the affected olive-growing regions (El Hamadna, Ain Nouissy, Bouhenni, Bentalha, Bir Touta and Tessala El Merdja). “Chemlal” and “Sigoise” are the most dominant olive cultivars in Algeria and varieties originated from Syria (Zaîti, Khodeiri, Terrella and Sorani) were classified as the most susceptible to the pathogen. While Bounguergueb, Cœur de bœuf and Limli were found to be moderately tolerant. Sylviane and Rougette were classified as the most tolerant cultivars. Disease incidence varied greatly among the cultivars (F=28.7, df= 7, P<0.000); and was correlated with the severity (y=2.04+104.9, R2= 0.32). Disease severity also varied among different cultivars (F= 72.6, df= 7, P<0.000). Analysis of variance shows a non-significant difference in the variation of incidence with exposure with probability values (F=0.43, df=278.2, P>5%).
Endoscopic Image-based Radiomics Classifiers for the Prediction of Neoadjuvant Chemoradiotherapy Response in Rectal Cancer Patients
Authors: Ozawa Tsuyoshi , Saikawa Yusuke , Hayama Tamuro , Nozawa Keijiro , Matsuda Keiji , Ishihara Soichiro , Kotoku Jun’ichi , Hashiguchi Yojiro 
Published: June 2022

Abstract
Objective
The accuracy of identifying a CRT-response by a pre-operative radiological examination is limited, and another approach is necessary. We constructed endoscopic image-based radiomics classifiers to predict the response of locally advanced rectal cancers (LARCs) to neoadjuvant chemotherapy (NA-CRT).
Design:
We enrolled 90 patients who had undergone NA-CRT followed by surgery. We selected 5,255 pre- and post-CRT endoscopic images of the tumors and extracted 860 texture features from each image. Using the extracted texture features, we applied 12 machine learning models to construct radiomics classifiers. The performances of the radiomics classifiers to predict a pathological complete response (pCR) and a CRT-response (good or not) were evaluated with a double cross-validation technique by calculating the area under the receiver operating characteristics curve (AUROC).
Results
In the prediction of pCR using pre-CRT images, the cubic support vector machine (SVM) model showed the highest AUROC of 0.816 in the image-basis analysis, and the AUROC of 0.904 in the patient-basis analysis. In the prediction of pCR using post-CRT images, the quadratic SVM model showed the highest AUROC (0.839) in the image-basis analysis, and the AUROC of 0.958 in the patient-basis analysis. The Gaussian SVM model demonstrated the best performances to predict a CRT-response in both pre- and post-CRT images with AUROCs of 0.792 and 0.841 in the image-basis analysis and 0.857 and 0.950 in the patient-basis analysis, respectively.
Conclusion
Our endoscopic image-based radiomics classifiers demonstrated robust performances to predict the CRT-response of LARCs and may contribute to the patients' management.
Function of temperature on almond moth demographic characteristics: Do diapausing individuals contribute to population growth rate?
Authors: Lin Ya-Ying , Tang Cheng-Kang , Saska Pavel , Güncan Ali , Yao May-Chi , Tuan Shu-Jen 
Published: June 2022

Abstract
The almond moth, Cadra cautella (Walker) (Lepidoptera: Pyralidae), is a recognized cosmopolitan pest of stored food products throughout its worldwide distribution. To enable effective control of this pest, a thorough understanding of the effect of temperature on their population growth is required. In this study, we investigated the population growth rate of group-reared C. cautella fed on brown rice at five different temperatures (15~35 °C) using the age-stage, two-sex life table program. At 15°C, the majority of larvae failed to reach the 2nd instar. At 35 °C, only 5 out of 150 individuals survived to the adult stage. There was no significant difference in fecundity between the three temperature groups (20, 25 and 30 °C), while a dramatic decline occurred at 35 °C (0.5 eggs/female). The intrinsic rates of increase of C. cautella were 0.0566, 0.1149, 0.1429, and -0.0901 d-1 at 20, 25, 30 and 35 °C, respectively, with significant difference between all values. Approximately 16.0% of late instar almond moth larvae showed signs of diapause induction at 20 °C, i.e., wandering behavior and delayed pupation. The development times of larvae (74.44 d) and pupae (17.13 d) were significantly longer in the diapausing cohort than in the non-diapausing cohort (54.89 d cv. 15.47 d). At 20 °C, the offspring of the diapausing individuals were still able to contribute 12.98% to the net reproduction rate of the entire cohort – an amount substantial enough to require attention when planning pest management programs. In conclusion, we suggest that 15 °C can effectively limit the damage caused by C. cautella population due to their inability to develop into later instars at this temperature.