bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using machine learning to study the effect of medication adherence in Opioid Use Disorder
Authors: Warren David , Marashi Amir , Siddiqui Arwa , Eijaz Asim Adnan , Pradhan Pooja , Lim David , Call Gary , Dras Mark 
Published: December 2022

Background
Opioid Use Disorder (OUD) and opioid overdose (OD) impose huge social and economic burdens on society and health care systems. Research suggests that Medication for Opioid Use Disorder (MOUD) is effective in the treatment of OUD. We use machine learning to investigate the association between patient’s adherence to prescribed MOUD along with other risk factors in patients diagnosed with OUD and potential OD following the treatment.

Methods
We used longitudinal Medicaid claims for two selected US states to subset a total of 26,685 patients with OUD diagnosis and appropriate Medicaid coverage between 2015 and 2018. We considered patient age, sex, region level socio-economic data, past comorbidities, MOUD prescription type and other selected prescribed medications along with the Proportion of Days Covered (PDC) as a proxy for adherence to MOUD as predictive variables for our model, and overdose events as the dependent variable. We applied four different machine learning classifiers and compared their performance, focusing on the importance and effect of PDC as a variable. We also calculated results based on risk stratification, where our models separate high risk individuals from low risk, to assess usefulness in clinical decision-making.

Results
Among the selected classifiers, the XGBoost classifier has the highest AUC (0.77) closely followed by the Logistic Regression (LR). The LR has the best stratification result: patients in the top 10% of risk scores account for 35.37% of overdose events over the next 12 month observation period. PDC score calculated over the treatment window is one of the most important features, with better PDC lowering risk of OD, as expected. In terms of risk stratification results, of the 35.37% of overdose events that the predictive model could detect within the top 10% of risk scores, 72.3% of these cases were non-adherent in terms of their medication (PDC <0.8). Targeting the top 10% outcome of the predictive model could decrease the total number of OD events by 10.4%.

Conclusions
The best performing models allow identification of, and focus on, those at high risk of opioid overdose. With MOUD being included for the first time as a factor of interest, and being identified as a significant factor, outreach activities related to MOUD can be targeted at those at highest risk.
Defining healthcare never events to effect system change: A protocol for systematic review
Authors: Zaslow Joanna , Fortier Jacqueline , Bowman Cara , de Gorter Ria , Tsai Ellen , Desai Dennis , O’Neill Peter , Mimeault Richard , Garber Gary 
Published: December 2022

Introduction
A never event is the most egregious of patient safety incidents. It refers to events that should theoretically never happen, such amputating the wrong limb. The term “never event” is used around the world by a variety of medical and patient safety organizations and is synonymous with sentinel events and serious reportable events. Unfortunately, there is little consensus about which events, in particular, are never events. These differing lists hinder potential collaboration or large-scale analyses. A recent systematic review by Hegarty et al. (2020) identified the need for a standardized definition for serious reportable events. The objective of our systematic review is to build on this by identifying which events are consistently or frequently identified as never events in order to isolate those which are core never events.

Materials and methods
A systematic review will be conducted using Medline, Medline in Process, Scopus, PsychINFO, Embase via OVID, and CINAHL via EBSCO databases, as well as grey literature. We will include articles of any study design that discuss never events or one of its synonymous terms in the context of medical care. Four independent reviewers will conduct the title and abstract as well as the full-text screening, and 2 reviewers will abstract data. Data will be analyzed using narrative synthesis. Results will be categorized by year and geographic location, and by other factors determined during full-text screening.

Discussion and conclusion
The lack of consensus regarding never events hinders progress in reducing their occurrence. Differing data sources makes comparison challenging, and limits the ability for patient safety groups to work collaboratively and share learnings with others. Identifying a core set of never events will serve as a first step to focus our efforts to reduce these harmful incidents.
Bibliometric analysis of the global research trends and hotspots in chordoma from 2000 to 2020
Authors: Chang Cuicui , Tang Kai , Gao Yifan , Dai Jingyao , Dai Chen 
Published: December 2022

Introduction
Chordoma is formed from embryonic residues or ectopic chordae and locally aggressive or malignant tumors. We visually analyzed the research tendency and hotspot of chordoma.

Methods
The bibliometric analysis was conducted from the Web of Science Core Collection database over the past two decades. The term and strategies were as follows: “TS = (chordoma) OR TS = (chordoblastoma) OR TS = (chordocarcinoma) OR TS = (chordoepithelioma) OR TS = (chordosarcoma) OR TS = (notochordoma). AND Language: English. AND Reference Type: Article OR Review”. A total of 2,118 references were retrieved and used to make a visual analysis by VOSviewer 1.6.15.

Results
The chordoma was on a steady rise and chordoma but remained the focus of scholars and organizations over the last two decades. The Chinese institutions and scholars lacked cooperation with their counterparts in other countries. The citations of documents and co-citation analysis of cited references suggested that M.L. McMaster, B.P. Walcott, P. Bergh, and S. Stacchiotti were leading researchers in this field of chordoma and their papers had been widely accepted and inspired recent researches. Keywords associated with recent chemotherapy, PD-1-related immunotherapy, and SMARCB1/integrase interactor 1 (INI1) in chordoma were a shortage of research and there may be more research ideas in the future by scholars. The research of chordoma will continue to be the hotspot.

Conclusions
Thus, explaining the molecular mechanism and potential role of transcriptional inhibition and immunologic responses to SMARCB1/INI1-negative poorly differentiated chordoma will be available for preclinical experiments and clinical trials and lead to new therapeutic opportunities for chordoma patients.
El amor es extraño
Authors: Pereira Domínguez Carmen , Torío López Susana 
Published: December 2022

George es profesor de música en un centro educativo y Benjamin es pintor y galerista. Ambos son personas mayores residentes en Nueva York. Tras 39 años de feliz convivencia, deciden legalizar su situación civil y contraer matrimonio. A la ceremonia asiste un grupo de familiares y amistades. Después del inolvidable evento, surgen problemas que repercutirán en la vida de George y Benjamin. Sin explicación alguna, George es despedido del colegio donde trabaja desde hace doce años. Como consecuencia, la pareja abandona su piso en Manhattan y solicita ayuda de parientes y amigos mientras encuentran una vivienda asequible.
Cuestiones económicas inesperadas hacen que ambos vivan alejados un tiempo. Benjamin se traslada al piso de su sobrino en Brooklyn, con su esposa e hijo. Y George se aloja en casa de dos amigos policías. La separación y la convivencia en hogares ajenos provoca que Benjamin y George sientan nostalgia y soledad. Por ello, se presenta un futuro incierto lleno de dificultades y emociones.
The role of erythrocytes and erythroid progenitor cells in tumors
Authors: Zhang Hao , Wan Guang-zhi , Wang Yu-ying , Chen Wen , Guan Jing-Zhi 
Published: December 2022

Abstract
In the current research context of precision treatment of malignant tumors, the advantages of immunotherapy are unmatched by conventional antitumor therapy, which can prolong progression-free survival and overall survival. The search for new targets and novel combination therapies can improve the efficacy of immunotherapy and reduce adverse effects. Since current research targets for immunotherapy mainly focus on lymphocytes, little research has been done on erythrocytes. Nucleated erythroid precursor stem cells have been discovered to play an essential role in tumor progression. Researchers are exploring new targets and therapeutic approaches for immunotherapy from the perspective of erythroid progenitor cells (EPCs). Recent studies have shown that different subtypes of EPCs have specific surface markers and distinct biological roles in tumor immunity. CD45+ EPCs are potent myeloid-derived suppressor cell-like immunosuppressants that reduce the patient’s antitumor immune response. CD45− EPCs promote tumor invasion and metastasis by secreting artemin. A specific type of EPC also promotes angiogenesis and provides radiation protection. Therefore, EPCs may be involved in tumor growth, infiltration, and metastasis. It may also be an important cause of anti-angiogenesis and immunotherapy resistance. This review summarizes recent research advances in erythropoiesis, EPC features, and their impacts and processes on tumors.
Thermal and multi-boiling analysis of a rectangular porous fin: A spectral approach
Authors: Kasali Kazeem Babawale , Akindeinde Saheed Ojo , Tijani Yusuf Olatunji , Adewumi Adebayo Olusegun , Lebelo Ramoshweu Solomon 
Published: December 2022

Abstract
Fins are commonly utilized to enhance (dissipate) heat in various engineering systems that include heat exchangers. In the present investigation, the impact of multi-boiling and thermo-geometric factors on a convective–radiative rectangular porous fin subjected to the temperature-dependent thermal conductivity of linear and non-linear variations is discussed extensively. The governing equations describing the problem were formulated with the aid of Darcy law. Similarity variables were employed to reduce the models to non-dimensional form. The solution of the governing dimensionless equation is approximated using the RK4 and spectral local linearization methods. Before parametric analysis, the agreement between the two numerical methods was established. Findings reveal that the non-linear variation of thermal conductivity shows better thermal efficiency than the linear variation. An improvement in the multi-boiling heat transfer parameter retards the temperature distribution of the fin. Furthermore, increasing the thermo-geometric parameter will result in a progressive decrease in the temperature of the fin. The results obtained in this work will aid in the design of heat exchangers and other heat transfer equipments.
Convection heat–mass transfer of generalized Maxwell fluid with radiation effect, exponential heating, and chemical reaction using fractional Caputo–Fabrizio derivatives
Authors: Sehra  , Sadia Haleema , Gul Nadia , Zeb Anwar , Khan Zareen A. 
Published: December 2022

Abstract
This article is directed to analyze the transfer of mass and heat in a generalized Maxwell fluid flow unsteadily on a vertical flat plate oscillating in its respective plane and heated exponentially. It explains the transfer of mass and heat using a non-integer order derivative usually called a fractional derivative. It is a generalization of the classical derivatives of the famous Maxwell’s equation to fractional non-integer order derivatives used for one-dimensional flow of fluids. The definition given by Caputo–Fabrizio for the fractional derivative is used for solving the problem mathematically. The Laplace transform method is used for finding the exact analytical solution to a problem by applying it to a set of non-integer order differential equations that are dimensionless in nature. These equations contain concentration, temperature, and velocity equations with specific initial and boundary conditions. Solutions of the three equations are graphically represented to visualize the effects of various parameters, such as the radiation parameter (Nr), the thermal Grashof number, the fractional parameter (α), the mass Grashof number, Prandtl effective number, Schmidt number, Prandtl number, the chemical reaction

(

η

2

)

({\eta }_{2})

, mass, and the temperature during fluid flow.
In situ bow reduction during sublimation growth of cubic silicon carbide
Authors: Kollmuß Manuel , Mauceri Marco , Roder Melissa , La Via Francesco , Wellmann Peter J. 
Published: December 2022

Abstract
Sublimation growth of cubic silicon carbide (3C–SiC) with diameters of 50 and 100 mm was performed on freestanding homoepitaxial grown seeds. For both seeds and sublimation grown crystals, two different relaxation axes with varying curvature could be observed with the higher bent axis aligned perpendicular to the original wafer flat. A general reduction in the wafer bow independent of the starting curvature and size of the seeds could be observed. Using the X-ray imaging, we could observe in situ that the bow reduction is linked to the growth of new material and cannot be initiated by heat up or cool down processes alone. Raman spectroscopy of the grown crystals revealed that the observed flattening goes along with a tensing of the seeding layers while the surface of the crystals remains free of a stress gradient. A slight concave bending of lattice planes along the main relaxation axis could be observed by high-resolution XRD rocking curve measurements while for the lower bent axis, no lattice plane bending occurred. Full width half maximum values of the (002) reflection showed values as low as 67 arcseconds proofing the possibility to grow large-area, high-quality 3C–SiC using sublimation growth.
Erfasste Betriebsdaten und ihre Qualität
Authors: Denkena Berend , Wichmann Marcel , Arnold Daniel 
Published: December 2022

Abstract
Produktionsdaten sind für Unternehmen Gold wert. Insbesondere für die Produktionsplanung und -steuerung sind die Daten wertvoll und besitzen einen großen Einfluss auf die Wirtschaftlichkeit des Unternehmens. Eine vorherige Analyse von erfassten Betriebsdaten aus einem Unternehmen legte Optimierungspotenziale in der Erfassungsmethodik nahe (vgl. [6]). Zur Validierung dieser Potenziale wurden nun weitere Betriebsdaten auf ihre Qualität und Nutzbarkeit hin geprüft. Dieser Beitrag zeigt die Ergebnisse einer Qualitätsanalyse von erfassten Betriebsdaten aus mehreren Unternehmen mit knapp neun Millionen Meldungen.
Sensorgestützte Analyse der Maschinenbedienung in der Kleinserienfertigung
Authors: Steenwerth Philipp , Lödding Hermann 
Published: December 2022

Abstract
Dieser Beitrag beschreibt ein Vorgehen, mit dem gleichzeitig sowohl die Mitarbeiter- als auch die Maschinenproduktivität an Maschinenarbeitsplätzen mithilfe von Low-Cost-Technologien und bestehenden Datenquellen analysiert werden kann. Das Konzept basiert darauf, Informationen aus verschiedenen Datenquellen zusammenzuführen und aus diesen sowohl für die Maschine als auch für den Werker Zustandsinformationen abzuleiten. Dazu wurde eine Web-Anwendung entwickelt, die es ermöglicht, die Analyse für jeden Anwendungsfall einfach und ohne tiefgreifende Vorkenntnisse individuell zu konfigurieren. Grundlage sind die Erfassung definierter Ereignisse durch geeignete Sensoren, bestehende Informationsquellen (z. B. MDE) und eine Web-App. Innerhalb der Anwendung werden die Analysedaten automatisiert verarbeitet und visualisiert. Hervorgehoben werden die Wartezeiten je Maschine und Werker. Darüber hinaus wird die Zusammensetzung der Wartezeiten ausgewertet. Der modulare Aufbau sowie die Verwendung von Low-Cost-Technologien ermöglichen eine effiziente und kostengünstige Analyse von Maschinenarbeitsplätzen.
Fotodegradación del contaminate azul de metileno por películas delgadas de TiO2 sensibilizadas con pigmentos aislados de biomasa cianobacteriana
Authors: Arcón Osorio Amado Enrique , Vallejo Lozada William Andrés , Diaz Uribe Carlos Enrique 
Published: December 2022

Las industrias textiles generan en sus procesos una diversidad de contaminantes, entre los que se encuentran los colorantes, la mayoría recalcitrantes no biodegradables y de difícil tratamiento por los métodos convencionales, por lo que se hace necesario implementar tecnologías alternativas de tratamiento para su degradación. La fotocatálisis heterogénea permite usar semiconductores como el dióxido de titanio (TiO2) para la oxidación de una gran cantidad de contaminantes de difícil tratamiento por los métodos convencionales. Una limitante importante para la utilización de semiconductores de TiO2 es el requisito de la luz UV, sin embargo, esta dificultad puede ser superada al sensibilizar el semiconductor con sustancias de origen sintético o natural para extender su actividad en la región visible. En este trabajo se evaluó el efecto de pigmentos separados (Clorofila a y ficocianina C) obtenidos de biomasa de cianobacterias aisladas de la Ciénaga de Malambo del municipio de Malambo del Departamento del Atlántico-Colombia sobre las propiedades fotocatalíticas del dióxido de titanio. Se sensibilizaron películas de TiO2 con cada uno de los extractos separados y la energía del band gap fue determinada por espectroscopia de reflectancia difusa. Finalmente se realizó el montaje de los ensayos a escala laboratorio para evaluar la degradación fotocatalítica del colorante azul de metileno. La clorofila a y la ficocianina C fueron identificados como sensibilizadores presentes en el extracto metanólico de la biomasa cianobacteriana. Adicionalmente, las películas de TiO2/Clorofila a presentaron un mayor porcentaje de fotodegradación en comparación de las películas de TiO2/Ficocianina C. Finalmente, los resultados obtenidos permitieron verificar que los colorantes naturales obtenidos del extracto de la biomasa, pueden ser utilizados para mejorar la respuesta foto catalítica del TiO2 bajo irradiación visible.
Künstliche Intelligenz und Marktmanipulation
Authors: Ringe Wolf-Georg , Azzutti Alessio , Stiehl Siegfried 
Published: December 2022

Zusammenfassung
Am modernen Kapitalmarkt werden zunehmend durch Künstliche Intelligenz (KI) und maschinelles Lernen (ML) gesteuerte Algorithmen eingesetzt. Neben enormen Effizienzgewinnen ergeben sich bei den fortschrittlichsten, selbstlernenden Algorithmen jedoch erhebliche Risiken für die Marktintegrität. Der vorliegende Beitrag zeigt auf, wie KI-Akteure selbständig Methoden des Marktmissbrauchs lernen können und konzentriert sich dabei auf Formen der Marktmanipulation und auf stillschweigende Absprachen. Der Beitrag hinterfragt zudem die Angemessenheit bestehender regulatorischer Rahmenbedingungen und Durchsetzungsmechanismen sowie aktueller Rechtsvorschriften zur Governance des algorithmischen Handels, um zunehmend autonomen und allgegenwärtigen algorithmischen Handelssystemen zu begegnen.
Preparticipation State Cardiac Screening Forms for Athletes
Authors: Blank Zane J. , Spicer Robert L. , Robinson Jeffrey A. 
Published: December 2022

BACKGROUND AND OBJECTIVES
Annual preparticipation physical evaluation (PPE) is used in the United States to screen adolescents for potential causes of sudden cardiac death. The American Heart Association recommends 14 screening elements of history and physical examination. This study sought to define the utilization of these screening elements by each of the 50 states before high school athletics.

METHODS
PPE forms were obtained from the public website of the high school athletics governing body in every state. Form content was analyzed to identify which of the 14 screening elements were explicitly fulfilled. Additional PPE forms provided by private/parochial schools, other professional societies, or independent groups were excluded from this study.

RESULTS
A total of 48 states (96%) had PPE forms posted online. The remaining 2 states (4%) deferred the specific method of PPE documentation to individual school districts and provided no standardized form. Of the 48 states providing PPE forms, 13 (27%) included all 14 American Heart Association screening elements. The median criteria included by each state was 11 (range 3–14). The 3 criteria most commonly absent were (1) the examination of femoral pulses to exclude coarctation (58%), (2) a family history of specific inherited cardiac disease (31%), and (3) personal history of hypertension (27%).

CONCLUSIONS
Annual preparticipation forms are important screening tools. Only a minority of states include all 14 cardiac screening elements recommended by the American Heart Association.
THE EFFECT OF THERMİC POWER PLANT WASTE FLY ASH ON PROPERTİES OF PORTLAND CEMENT
Authors: YÜCETÜRK Şeyma 
Published: December 2022

Today, increasing environmental awareness, national and international environmental policies are in parallel and getting stricter. The Concrete sector is criticized and under spotlight for consuming a billion tons natural resources and large amount of energy and high emissions from cement production - especially CO2. These criticisms are tried to be resolved with alternative ways. Fly ash in concrete and cement production, with the use of industrial wastes with pozzolanic properties such as blast furnace slag and silica fume, more sustainable and more durable end products can be obtained. The Fly ash, which is wastage of coal-based thermal power plants, it is easily accessible and it is one of the most used cement substitute materials due to its suitable fineness and chemical structure. With the appropriate use of fly ash, sufficient or even superior performance can be achieved in concrete.
In this thesis study, the fly ash supplied from the thermal power plant will be substituted in CEM I 42.5 R cement at the rates of 0%-10%-20%-30% and will be subjected to various analysis studies determined in accordance with Turkish standards in the cement industry quality control laboratory.
In this study, the physical, chemical and mechanical effects of fly ash on Portland cement were investigated by using fly ash from the Thermal Power Plant and CEM I 42.5 R cement together.
Comparison of stapler and hand-sewn roux en Y jejunal anastomosis in children
Authors: ALKAN Murat , TUTUŞ Kamuran , TÜRKER ÇOLAK Selcan , FAKIOĞLU Ender , KILIÇ Şeref Selçuk , OZDEN Onder , TUNCER Recep 
Published: December 2022

outcomes of stapled and hand-sewn Roux-en-Y intestinal anastomoses in childhood.
Materials and Methods: At a university hospital, the records of the children who underwent roux-en-Y anastomosis between December 2007 and December 2014 were reviewed. The data were compared according to the roux-en-Y anastomosis technique used (stapled versus hand-sewn).
Results: A total of 52 patients had undergone roux-en-Y anastomosis. All had biliary atresia or choledochal cyst. Thirty-one of the patients were diagnosed with biliary atresia and 21 with choledochal cysts. Staple anastomosis technique was used in 16 of the patients with biliary atresia and 9 of the patients with choledochal cyst. Both in biliary atresia and choledochal cyst cases; operations with stapled anastomosis were significantly shorter than the ones with hand-sewn anastomosis. Among the biliary atresia cases, post-operative oral feeding was initiated significantly earlier in the stapled group, with its lower risks of post-operative cholangitis and longer hospital stay than 7 days.
Conclusion: This is the first study in children, confirming the time-saving advantage of stapled anastomosis over hand-sewn, during roux-en-Y anastomosis for biliary atresia and choledochal cyst; along with the safety of stapler use, including the neonates. Stapled anastomosis yields lower complication rates, faster function gain with earlier feeding and hospital discharge.