bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early treatment discontinuation in patients with deficient mismatch repair or microsatellite instability high metastatic colorectal cancer receiving immune checkpoint inhibitors
Authors: Taieb Julien , Ambrosini Margherita , Alouani Emily , Lonardi Sara , Sinicrope Frank A , Decraecker Marie , Boileve Alice , Hafliger Emilie , Mazard Thibault , Pernot Simon , Parent Pauline , Ros Javier , Overman Michael J , Jayachandran Priya , Nasca Vincenzo , Salvatore Lisa , Guimbaud Rosine , Cremolini Chiara , Tougeron David , Pietrantonio Filippo 
Published: January 2025

BackgroundImmune checkpoint inhibitors (ICIs) are recommended to treat patients with deficient mismatch repair/microsatellite instability high (dMMR/MSI-H) metastatic colorectal cancer (mCRC). Pivotal trials have fixed a maximum ICI duration of 2 years, without a compelling rationale. A shorter treatment duration has the potential to improve patients' quality of life and reduce both toxicity and cost without compromising efficacy. Here we examine whether early treatment discontinuation (ETD) before 13 months in patients without progressive disease (PD) can lead to similar long-term disease control compared with a longer treatment duration (LTD).MethodsTo assess whether ETD is associated with similar outcomes compared with LTD, we assembled an international cohort of patients with dMMR/MSI-H mCRC treated with ICIs who stopped treatment for a reason other than PD within 395 days (ETD group) and compared them to those who continued for >395 days (LTD group). Outcomes were adjusted for patient/tumor characteristics. Primary endpoint was progression-free survival (PFS) and secondary endpoints were objective response rate (ORR), overall survival (OS) and safety.ResultsOf 976 patients, 137 and 394 were allocated to the ETD and LTD groups, respectively. In the ETD group, treatment was discontinued due to toxicity (n=56), objective response (n=43), surgery (n=28), patient decision (n=2) or other reasons (n=8). Baseline characteristics were well balanced between the two groups: 22% in both groups received both anti-programmed death-(ligand) 1 (anti-PD-(L)1) + anti-cytotoxic T-lymphocyte antigen-4 (anti-CTLA-4); all others received anti-PD-(L)1 monotherapy. ORR to ICIs was 81% in both groups. Median duration of treatment was ~7 months in the ETD and ~24 months in the LTD group. After a median follow-up of 44 months (IQR: 30–67), similar PFS (HR: 0.92, 95% CI: 0.60 to 1.40, p=0.69) and OS (HR: 1.15, 95% CI: 0.66 to 1.99, p=0.62) from the start of ICIs were observed in ETD and LTD patients. In the ETD group, 28 (20%) patients had a PFS event and 9 restarted ICIs with a disease control rate of 66%.ConclusionsIn our international series of dMMR/MSI-H mCRC, ETD of ICIs in the absence of PD did not seem detrimental in terms of PFS and OS compared with continuing treatment beyond 1 year. Randomized clinical trials to compare short and long treatment duration are now warranted.
The effects of acute hot-water immersion on force steadiness and motor unit discharge rate variability in young, healthy adults
Authors: Rodrigues Patrick , Orssatto Lucas B.R. , Trajano Gabriel S. , Wharton Lee , Minett Geoffrey M. 
Published: January 2025

This study examined the effects of core and muscle temperature on force steadiness and motor unit discharge rate (MUDR) variability after a hot-water immersion session. Fifteen participants (6 women; 25 ± 6 years) completed neuromuscular assessments before and after either 42 °C (hot) or 36 °C (control) water immersion. Force steadiness was measured during knee extension, while HD-sEMG signals were recorded from vastus lateralis and medialis for MUDR variability analysis. Following water immersion, force steadiness decreased by 0.11% ( p < 0.05; d = 0.38) and MUDR variability increased by 1.25% ( p < 0.01; d = 0.57) potentially driven by increased muscle temperature. Elevated core temperature did not further affected these changes.
Diagnostic Accuracy of CT and MR Venography in Acute Cerebral Venous Thrombosis
Authors: Räty Silja , Hiltunen Sini , Georgiopoulos Georgios , Adamou Anastasia , Ajdini Erold , Virtanen Pekka , Korvenoja Antti , Ntaios George , Putaala Jukka , Strbian Daniel 
Published: January 2025

Background: Cerebral venous thrombosis (CVT) is a rare cause of stroke with variable clinical presentation and challenging diagnosis. Computed tomography venography (CT‐V) or magnetic resonance venography (MR‐V) are recommended for detecting CVT, but their diagnostic performance is unclear. This systematic review examines the accuracy of CT‐V and MR‐V in diagnosing CVT.Methods: We performed a systematic literature search up to 02 July 2023 to retrieve original articles studying the diagnostic accuracy of CT‐V or MR‐V in patients with suspected CVT. Studies with a reference standard comprising at least one other imaging method alone or in addition to clinical data were included. The quality of studies was assessed with the QUADAS‐2 tool.Results: We found eight studies (478 subjects) published between 1995 and 2022 that compared one or more diagnostic methods to a reference: CT‐V (four studies, n = 95) and/or MR‐V (three studies, n = 83) versus clinical and radiological consensus, CT‐V versus MR‐V (two studies, n = 292), or MR‐V versus digital subtraction angiography (DSA) (one study, n = 52). They reported excellent diagnostic accuracy for both CT‐V (sensitivity 100%, specificity 94%–100%) and MR‐V (sensitivity 90%–100%, specificity 71%–100%) compared to clinical and radiological consensus, for CT‐V compared to MR‐V (sensitivity 96%–100%, specificity 99%–100%), and for MR‐V compared to DSA (sensitivity 100%, specificity 71%). The heterogeneity of the studies allowed only an exploratory meta‐analysis. The risk of bias in the use of the reference standard was high.Conclusions: Our systematic review found a high accuracy of CT‐V and MR‐V for detecting CVT, suggesting that CT‐V is a feasible option for centers with limited access to MR‐V. However, the small sample sizes and variable reference methods impair conclusions drawn from the current literature.
Predictive Application Value of Metagenomic Next‐Generation Sequencing in the Resistance of Carbapenem‐Resistant Enterobacteriaceae
Authors: Tian Jiacheng , Wang Chengtan , Song Pingping , You Zhiqing , Jia Xiuqin , Li Xuan , Pang Feng 
Published: January 2025

Objective: Although metagenomic next‐generation sequencing (mNGS) technology has achieved notable outcomes in pathogen detection, there remains a gap in the research regarding its application in predicting the antibiotic resistance of pathogenic bacteria. This study aims to analyze the clinical application value of mNGS in predicting the resistance of carbapenem‐resistant Enterobacteriaceae (CRE), as well as the relevant influencing factors, thereby providing valuable insights for clinical antimicrobial therapy.Methods: Nonduplicate isolates of Enterobacterales bacteria collected from Liaocheng People’s Hospital from April 2023 to June 2024 were selected, and CRE bacteria were screened. mNGS was used to detect resistance genes, and the results were compared with those of polymerase chain reaction (PCR) to evaluate the specificity and sensitivity of gene detection. Furthermore, the performance of mNGS in identifying pathogenic microorganisms and predicting antibiotic resistance was assessed by comparing the sequencing results with those of antimicrobial susceptibility testing (AST).Results: A total of 46 isolates were confirmed as CRE through traditional AST and were further identified using the Vitek MS and Vitek 2 systems. The results indicated 27 isolates of Klebsiella pneumoniae, 14 isolates of Escherichia coli, 2 isolates of Enterobacter hormaechei, 2 isolates of Enterobacter cloacae, and 1 isolate of Citrobacter freundii. These isolates were subjected to both mNGS and PCR for detection. The calculation of the area under the receiver operating characteristic (ROC) curve demonstrated the reliability of mNGS in detecting resistance genes.Conclusion: mNGS demonstrated high sensitivity in predicting the presence of carbapenemase resistance genes in CRE, showing potential in early indication of isolate resistance information, thereby facilitating timely guidance for clinical treatment strategies.
Pediatric Interventions in a Sanfilippo Syndrome Patient Under General Anesthesia: A Case Report
Authors: Al Malak Ahmad , Issawi Hassan , Hassoun Mohammad , Al Halabi Mohammad 
Published: January 2025

Background: Mucopolysaccharidosis (MPS) Type III (MPS III) or Sanfilippo syndrome is a rare autosomal recessive inherited metabolic disorder. This disorder is responsible for lysosomal storage disorder at the cellular aspect. Due to lysosomal enzyme perturbance leading to the alteration of macromolecule metabolisms, this cellular perturbance causes multiple severe systemic and mental outcomes. Sanfilippo syndrome is the most frequent lysosomal disorder among the different types of MPS.Case Presentation: A 9‐year‐9‐month‐old female was presented at our private clinic accompanied with her parents and referred from a general practitioner, and the preclinical examination revealed atypical craniofacial structure and skeletal features such as abnormal posture and movements adding on atypical behavioral manifestations such as temper tantrums, speech difficulties, dementia, and destructive behavior.
Iliac Crest Bone Block Autograft Transfer for Ballistic Posterior Glenoid Fracture: A Case Report
Authors: Serotte Jordan Cook , Baker Hayden , Lee Cody , Strelzow Jason A. 
Published: January 2025

Case: A 25‐year‐old male presented with a ballistic fracture of the right glenoid resulting in > 30% loss of the posterior glenoid articular surface and acute posterior glenohumeral instability that was treated with open reduction internal fixation with iliac crest autograft transfer.Conclusion: There is limited consensus on the operative management of ballistic intra‐articular fractures due to the heterogeneity of these injuries. Acute posterior glenohumeral instability secondary to a ballistic fracture is a rare injury pattern. In this case, we were able to successfully treat posterior glenohumeral instability with iliac crest autograft transfer and open reduction internal fixation.
Early Enteral Nutrition May Improve Survival in Patients With Cardiogenic Shock
Authors: Zheng Liangliang , Duan Jingwei , Duan Baomin 
Published: January 2025

Background and Aim: International guidelines recommend early enteral nutrition (EEN) for critically ill patients. However, evidence supporting the optimal timing of EN in patients diagnosed with cardiogenic shock (CS) is lacking. As such, this study aimed to compare the clinical outcomes and safety of EEN versus delayed EN in patients diagnosed with CS.Methods: This retrospective cohort study was conducted using data from the Medical Information Mart for Intensive Care IV version 2.2 database. Patients who received EN within 2 days of admission were assigned to the EEN group. A 1:1 propensity score‐matched (PSM) analysis was performed to control for bias in baseline characteristics and ensure the reliability of the results. To exclude the impact of confounders, an adjusted proportional hazards regression model was used to verify the independence between EEN and survival outcomes.Results: Of 1846 potentially eligible patients, 1398 received EEN and 448 received delayed EN. After 1:1 PSM, 818 patients were assigned to the EEN (n = 409) and delayed EN (n = 409) groups. Regarding cumulative survival, patients with CS receiving EEN experienced better 30‐, 90‐, and 180‐day survival outcomes than the delayed EN group (hazard ratio [HR] 0.803 [95% confidence interval [CI] 0.647–0.998], p = 0.045; HR 0.729 [95% CI 0.599–0.889], p = 0.001; and HR 0.778 [95% CI 0.644–0.938], p = 0.008, respectively). After adjusting for confounders, EEN was found to be independently associated with survival outcomes. Moreover, EEN did not increase the risk(s) for ileus, aspiration pneumonia, or gastrointestinal bleeding. Patients who received delayed EN experienced longer hospital stays than those receiving EEN (17 days [interquartile range [IQR] 10–25] versus 12 days [IQR 7–19 days], respectively; p < 0.001).Conclusion: EEN was not associated with harm, but rather with improved survival outcomes in patients diagnosed with CS. Further studies are required to verify these findings.
Interventions for Increasing Pedestrian Visibility to Prevent Injury and Death: A Systematic Review
Authors: Khabiri Roghayeh , Jahangiry Leila , Birgani Hosna Rashidi , Sadeghi-bazargani Homayoun 
Published: January 2025

Background: Pedestrian visibility is a critical factor in reducing the number of pedestrian accidents on roads. A review of pedestrian visibility literature may reveal different types of interventions that are feasible for promoting pedestrian visibility. Therefore, this study aimed to identify the interventions to increase pedestrian visibility.Methods: A systematic search was conducted on electronic databases including PubMed, Scopus, and Google Scholar for full‐text articles published from 2003 to December 17, 2023. All interventions used for pedestrians to increase their visibility were considered for the review.Results: Our systematic search identified 13,472 records, of which 5749 duplicated articles were removed. The remaining 7723 records were initially screened on the basis of title and abstract. After full reading of 804 articles, finally, 14 articles were eligible to be included in the review. The strategies for the visibility of pedestrians were categorized based on the nature of strategies intervened on pedestrians, components, and benefits. The categorizations highlight a diverse range of strategies employed to enhance pedestrian visibility, including technological solutions, wearable, nonverbal communication, detection‐based warnings, and educational interventions.Conclusion: The diverse range of strategies explored in the reviewed studies underscores the multidimensional approach required to enhance pedestrian visibility and safety. It highlights the need for effective interventions to improve detection and recognition of pedestrians by drivers, which is crucial for reducing accidents. The findings suggest that a combination of technological advancements, wearables, nonverbal communication, detection‐based warnings, and educational interventions can contribute to a safer pedestrian environment. However, further research is needed to assess the long‐term effectiveness and real‐world applicability of these strategies.
Psychometric Properties of the Persian Version of Sickness Impact Profile‐30 (SIP‐30) in Community‐Dwelling Older Adults
Authors: Siavash Sajad , Ghaffari Amin , Taghizadeh Ghorban , Lajevardi Laleh , Azad Akram 
Published: January 2025

Purpose: Accurate measurement tools are essential for evaluating the health‐related quality of life in older adults. We aimed to translate and evaluate the psychometric properties of the Sickness Impact Profile‐30 (SIP‐30) in community‐dwelling older adults.Materials and Methods: One hundred and fifty older adults participated in this study. To evaluate construct validity, its correlation with General Health Questionnaire‐28, Geriatric Depression Scale‐15, Hospital Anxiety and Depression Scale, Modified Health Assessment Questionnaire, Numeric Pain Rating Scale, and Fullerton Advanced Balance Scale was assessed. Reliability features were also investigated.Results: The results of construct validity analysis demonstrated a moderate to high (r = 0.61–0.84) correlation between the total score of SIP‐30 and GHQ‐28, GDS‐15, HADS, MHAQ, and NPRS. There was a moderate inverse (r = −0.67) correlation between the total score of the SIP‐30 and the FAB Scale. Test–retest reliability (ICC > 0.83) and internal consistency (α = 0.94) of the Persian SIP‐30 were high.Conclusions: The results indicated that the Persian SIP‐30 is a reliable and valid measure to assess health‐related quality of life in community‐dwelling older adults.
Shenlian Decoction Ameliorates LPS‐Related Inflammation in db/db Mice: Coupling Network Pharmacology With Experimental Verification
Authors: Liu Yi-fan , Liu Yuan-yuan , Xiao Yao , Huang Wei-jun , Sun Rui-xi , Hu Jie , Fu Xiao-zhe , Tian Chu-xiao , Fu Qiang , Zhao Jin-xi 
Published: January 2025

Background: Shenlian (SL) decoction, a renowned traditional Chinese formula for diabetes mellitus, has also been employed to treat intestinal disorders. Previous studies have demonstrated the efficacy of SL decoction in regulating blood glucose and intestinal bacteria. Nevertheless, further analysis is required to elucidate the mechanistic link between SL decoction–mediated improvement of intestinal function and treatment of Type 2 diabetes mellitus (T2DM).Methods: Firstly, the active ingredients of SL decoction were sourced from the Traditional Chinese Medicine System Pharmacology (TCMSP) database, with putative targets of active ingredients being predicted using the same database. Secondly, the Online Mendelian Inheritance in Man (OMIM) and GeneCards databases were employed to screen the aforementioned targets that act on T2DM, and protein–protein interaction (PPI) networks were constructed in accordance with the results. Thirdly, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted using the Database for Annotation, Visualization, and Integrated Discovery (DAVID), which resulted in a comprehensive analysis of the association between SL decoction for the treatment of T2DM and the modulation of intestinal functions. Finally, the effect of the SL decoction on predicted lipopolysaccharide (LPS)‐related targets, as well as intestinal function markers, was validated through in vivo experimentation.Results: A total of 36 active ingredients and 145 potential targets of SL decoction were predicted. GO enrichment analysis indicated that the principal biological processes by which the SL decoction acted against T2DM were responses to LPSs, while KEGG enrichment analysis identified the nuclear factor kappa B (NF‐κB) signaling pathway and toll‐like receptor signaling pathway as the key pathways involved. The in vivo experiments showed that SL decoction improved glycolipid metabolism indexes, inflammatory factor levels, and LPS levels in db/db mice. The immunohistochemical results demonstrated that the SL decoction restored the expression of Occludin, Claudin‐1, and ZO‐1 in the intestine and inhibited the expression of toll‐like receptor 4 (TLR4), myeloid differentiation primary response gene 88 (MYD88), and NF‐κB in both the intestine and pancreas. Furthermore, it may influence the levels of short‐chain fatty acids (SCFAs) in feces.Conclusions: This research investigated the multigene pharmacological mechanism of SL decoction against T2DM using network pharmacology and in vivo experiments. SL decoction treatment of T2DM may reverse inflammation by inhibiting LPS‐related pathway activation and improving intestinal function.
Fast Preparation of Fish Sauce Treated With Marine Protease‐Producing Bacillus zhangzhouensis sp.
Authors: Bai Niuniu , He Jianlin , Hong Bihong , Wu Zelong , Wang Liping , Shao Zongze 
Published: January 2025

Background: Traditional fish sauce is made from fish that have been coated in 30%–40% sea salt and fermented for up to 2 years. The preparation requires a long time, and the fish source contains considerable biogenic amines. In this report, by measuring the growth curve and identifying the intracellular enzyme and the activity of protease, B. zhangzhouensis with the highest activity of protease production was selected from eight strains, which were applied to the fermentation process of fish sauce.Results: Optimized by response surface methodology, the content of amino nitrogen was taken as the response value, and the best fermentation conditions were 4.15% inocula, pH 9.13, and 36.3°C. Under the optimized conditions, fish sauce samples were obtained by fermentation with B. zhangzhouensis for 15 h, 3 days, 7 days, 15 days, and 30 days, respectively. The contents of amino nitrogen, total nitrogen, biogenic amine, and various flavor substances were determined and compared with the traditional 2‐year‐fermented fish sauce. As a result, the 7‐day‐fermented fish sauce using B. zhangzhouensis had a similar composition of flavor substances to traditional fish sauce, but a much lower level of biogenic amines.Conclusion: The new method of preparing fish sauce with a fermentation condition of 4.15% B. zhangzhouensis, pH 9.13, and 36.3°C can improve the production efficiency of fish sauce, and the flavor is similar to that of traditional fish sauce.
Quality of Life After Laser Vision Correction: A Systematic Review and Meta‐Analysis
Authors: Peyman Alireza , Irajpour Matin , Yazdi Maryam , Dehghanian Farzaneh , Noorshargh Pegah , Broumand Yasaman , Fatemi Farnaz , Pourazizi Mohsen 
Published: January 2025

Purpose: To analyze patients’ quality of life (QOL) after laser vision correction (LVC) from a worldwide literature review.Methods: Studies of prospective or cross‐sectional design which evaluated QOL in patients after LVC and compared that to preoperative values or a matched group of emmetropes were included. The Web of Science, PubMed, Scopus, and ProQuest were searched for relevant articles published until February 2024. The fixed‐ or random‐effects models were used to estimate the weighted mean difference (WMD) for postoperative QOL changes. Meta‐regression was conducted for adjusting the effects of potential confounders.Results: A total of 11 peer‐reviewed articles (1753 patients) were included in the study. LVC improved QOL of patients at one (SMD = 0.38, 95% CI: 0.15, 0.60), three (SMD = 1.03, 95% CI: 0.55, 1.50), and six months after surgery (SMD = 0.71, 95% CI: 0.30, 1.11). In meta‐regression analysis, QOL improvement was lower in older patients compared to younger ones (β = −0.06, 95% CI: −0.11, −0.01). Also, no statistically significant difference was noted while comparing QOL in post–laser refractive surgery patients and emmetropes (SMD = −0.44, 95% CI: −0.95, 0.07).Conclusion: Patients undergoing LVC experience significant improvements in QOL, particularly in younger subjects, and achieve comparable QOL to individuals with emmetropia.
Nuclear Alpha‐Synuclein in Parkinson’s Disease and the Malignant Transformation in Melanoma
Authors: Jimenez-Capdeville María E. , Chi-Ahumada Erika , García-Ortega Francisco , Castanedo-Cazares Juan Pablo , Norman Robert , Rodríguez-Leyva Ildefonso 
Published: January 2025

Background: Alpha‐synuclein (ASyn), a marker of Parkinson’s disease (PD) and other neurodegenerative processes, plays pivotal roles in neuronal nuclei and synapses. ASyn and its phosphorylated form at Serine 129 (p‐ASyn) are involved in DNA protection and repair, processes altered in aging, neurodegeneration, and cancer.Objective: To analyze the localization of p‐ASyn in skin biopsies of PD patients and melanoma.Methods: Biopsies from 26 PD patients, 20 melanoma patients, and 31 control subjects were probed and analyzed with a p‐ASyn antibody by immunohistochemistry and immunofluorescence. Nuclear positivity was quantified by image analysis.Results: Peripheral nerve endings from healthy subjects show little p‐ASyn immunopositivity but notable axonal presence in PD. Control subjects show immunopositivity to p‐ASyn along all epidermic strata and scarce presence in their cytoplasm. In contrast, its nuclear presence in PD is weaker, with a higher cytoplasmic and intercellular presence. Nuclear p‐ASyn in melanoma varied from similar to control skin in early stage melanoma to a higher rate of empty nuclei in the intermediate stage and total absence of nuclear p‐ASyn in severe cases.Interpretation: These findings support the nuclear localization of p‐ASyn in skin cells and show that its presence decreases PD and almost disappears in the malignant transformation of melanocytes, redistributing to the cytoplasm and intercellular spaces. This confirms the association between PD and melanoma, providing crucial insights into the role of p‐ASyn in both diseases.Trial Registration: ClinicalTrials.gov identifier: NCT01380899.