bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypocalcemic Seizures in Infancy and its Relationship with Maternal Vitamin D Deficiency
Authors: Biswas Rabi , Hasan ABM Kamrul 
Published: December 2022

Background: Hypocalcemia accounts for a large number of seizures in infants presented at the emergency department of our hospital.
Objective: To evaluate the role of Vitamin D deficiency as the etiology of hypocalcemic seizures in infancy and its relationship with maternal Vitamin D levels.
Methods: Cross sectional hospital based study over a period of 35 months from July 2016 to June 2019. Total 60 infants with hypocalcemic seizures were enrolled into the study. Blood samples were taken for serum total calcium, inorganic phosphate, alkaline phosphatase, albumin, 25(OH)D and PTH from the child. Maternal serum 25(OH)D levels were measured as well.
Results: The mean age of the studied infants was 3.6 (±1.2) months. All patients had low total calcium (mean 6.5 mg/dl) and most of them had low inorganic phosphate (mean 3.5 mg/dl), while all of them had raised alkaline phosphatase (mean 1093.50 IU/L) and PTH levels (mean104 pg/ml) at presentation. Forty percent of infants were severely deficient and 60% were deficient in vitamin D; none of them were vitamin D sufficient. Among their mothers, none were sufficient, 10% were insufficient, 45% were deficient, and 45% were severe deficient of vitamin D. Neonatal 25(OH)D showed strong negative correlation with their serum PTH levels and strong positive correlations with maternal serum 25(OH)D levels.
Conclusion: All infants in our setting presented with hypocalcemic seizures were found due to Vitamin D deficiency and it was mostly related to maternal Vitamin D deficiency.
DS (Child) H J 2021; 37(2): 98-102
Complications of Paediatric Ventriculoperitoneal (VP) Shunt: Experience in A Tertiary Care Hospital
Authors: Paul Swapan Kumar , Islam Rakibul , Ghosh Paritosh Kumar , Biswas Prosanto Kumar , Hossain Delwar , Rashid Md Aminur 
Published: December 2022

Background: Ventricloperitoneal (VP) shunt is the most commonly used shunt procedure in children because of the capacity of the peritoneum to resorb fluid like Cerebrospinal fluid (CSF). Primary and subsequent peritoneal catheter placement is relatively easy procedure to be done. VP shunt procedures are associated with varieties of complications.
Methods: A prospective study was done from July 2017 to June 2021 in Faculty of Paediatric Surgery, Bangladesh Shishu Hospital & Institute. A total number of cases underwent VP shunt surgery were 192. We had analyzed 82(42.71%) patients of VP shunt surgery who had various shunt related complications and analyzed the predisposing risk factors and spectrum of complications.
Results: The mean age was 16±14 months and median age was11.75 months. Out of 82 patients 56 (68.29%) were male and 26(31.71%) were female. Seventy (85.37%) patients had single complication and 12(14.63%) had more than 1 complications. Twenty four (29.27%) patients had infective complication and 58(70.73%) had mechanical complication. Infective complications (24, 29.27%) include shunt tract abscess (41.66%), CSF leak (16.67%) exposure of shunt tube through anus (16.67%), wound infection (16.67%). Mechanical complications were present in 58(70.73%) cases and 40(48.78%) had ventricular end malformation, 24(29.27%) peritoneal end and 18(21.95%) had both end malformation.
Conclusion: With this prospective study of complications of VP shunt, age at initial shunt surgery, insertion and important patient-related predictors of shunt failure. The different predominant etiological factors the interval between the age of initial shunt placement and onset of complications were the most responsible for early and late shunt failure were infective and mechanical complications respectively.
DS (Child) H J 2021; 37(2): 129-134
Sistem Predictive Maintenance Bearing Pada Mesin Super Mixer Granula Dengan Menggunakan Sensor Acceelerometer MPU-6050
Authors: Ardhian Nugroho Oktavianus , Angel Tandiawan Catherine 
Published: December 2022

PT Hexpharm Jaya Laboratories adalah salah satu perusahaan yang merupakan bagian dari Kalbe Company yang bergerak secara khusus dalam bidang pengembangan, produksi, pengolahan, dan pemasaran obat. Proses pengolahan bahan baku obat di PT Hexpharm Jaya Laboratories menggunakan beberapa mesin, salah satunya adalah mesin SMG (Super Mixer Granula). Mesini ini digunakan untuk mencampur bahan baku obat dan merupakan proses pengolahan awal sebelum menjadi granul. Masalah yang sering timbul pada mesin ini yaitu masalah penggantian bearing. Bearing yang terpasang di bagian shaft penghubung gearbox dengan granula sering mengalami kerusakan yang menyebabkan produksi berhenti / breakdown. Proses unplanned maintenance ini sebelumnya sudah coba diatasi dengan penghitungan umur bearing dan alignment shaft penghubung untuk menggurangi getaran, tetapi bearing tetap mengalami kerusakan sebelum waktunya. Dalam tulisan ini dibuatlah suatu sistem untuk memprediksi kapan bearing perlu diganti dengan mencatat data getaran yang terjadi. Tujuan dari penelitian ini adalah mendapatkan sistem yang mencegah terjadinya unplanned maintenance sehingga tidak mengganggu proses produksi. Dengan menggunakan sensor MPU-6050 getaran pada bearing diukur dan direkam. Hasilnya didapat suatu sistem predictive maintenance yang dapat mencegah terjadinya breakdown yang mengakibatkan berhentinya proses produksi. Sistem ini dibuat dengan merekam getaran yang terjadi ketika mesin bekerja dan digunakan sebagai cara untuk memprediksi lifetime bearing. Sistem ini berhasil mengukur nilai getaran bearing dan dapat ditampilkan sehingga membantu teknisi maintenance memperkirakan waktu yang tepat untuk penggantian bearing di mesin SMG.
Analisis Metode Failure Mode and Effect Analysis (FMEA) dan Fault Tree Analysis (FTA) Untuk Identifikasi Penurunan Kualitas Produk Toyota Hi-Ace (Studi Kasus di PT. EDS Manufacturing Indonesia)
Authors: Lestari Sri , Septiyana Diah , Yuniawati Winda 
Published: December 2022

Tingkat kegagalan (defect) tinggi merupakan suatu permasalahan yang selalu diupayakan untuk diminimasi oleh suatu perusahaan guna meningkatkan kualitas dari produk yang dihasilkan, begitu juga yang dilakukan oleh PT. EDS Manufacturing Indonesia (PEMI). PT. EDS Manufacturing Indonesia (PEMI) merupakan perusahaan manufaktur carline Toyota HI-ACE untuk kendaraan bermotor. Oleh karena kegagalan yang tinggi pada produk bisa merugikan perusahaan, maka dilakukan penelitian ini dengan menggunakan 2 metode yaitu metode Failure Mode and Effect Analysis (FMEA) dan Fault Tree Analysis (FTA). Penelitian dengan metode Failure Mode and Effect Analysis (FMEA) pada PT. EDS Manufacturing Indonesia di carline Toyota HI-ACE menunjukkan adanya berbagai moda kegagalan pada area produksi dan quality assurance. Metode FMEA dilakukan dengan memprioritaskan RPN dari 2 moda kegagalan yang menjadi prioritas berdasarkan RPN tertinggi yaitu wrong dimension dan demage insulation. Tahapan berikutnya adalah menganalisa resiko yang berperan terhadap kegagalan dengan menggunakan Fault Tree Analysis (FTA). Berdasarkan data analisis dengan metode FMEA diperoleh nilai RPN tertinggi terdapat pada mode kegagalan demage insulation dengan nilai RPN sebesar 324 atau sebesar 14.78% dan mode kegagalan wrong dimension dengan nilai RPN sebesar 280 atau sebesar 12.77%.

Kata kunci: mode kegagalan, analisa resiko, FMEA, FTA, nilai RPN
Active Substances Isolated from the Secretion of Siberian Musk Deer in a Liposomal Dosage Form
Authors: Gasanov M. T. , Fokin Yu. V. , Lyublinskiy S. L. , Alimkina O. V. , Taboyakova L. A. , Karkischenko V. N. 
Published: December 2022

Liposomal forms of preparations containing biologically active substances extracted from renewable sources of raw materials of plant and animal origin are attracting considerable research and practical interest. Liposomal drugs are efficiently absorbed in the gastrointestinal tract, retaining their structure while passing through the liver and entering the target cell. This allows either smaller amounts of the active substance to be used without losing bioavailability or its effective concentration to be increased.Deer musk liposomes administered at doses equivalent to 300, 1500 and 3000 mg/person/day were found to exhibit an actoprotective effect, whose intensity at the minimum dose (300 mg) is comparable to that achieved at the maximum dose (3000 mg).A course daily transpalatal administration of musk deer liposomes for 14 days was established to statistically significantly improve the indices of physical endurance and working capacity of rats in forced swimming tests under load, kineso-hydrodynamic models of swimming and rotarod performance tests. The observed increase in indicators persisted for another seven days after the cessation of administration, which indicates pharmacological cumulation. The tested drug reduces locomotor and orienting-exploratory activity, at the same time as exhibiting no adverse effect on the psycho-emotional and intoxication status of animals. In addition, no local irritant action on the route of administration was noted. The drug is assigned to toxicity class VI (relatively harmless).
HUBUNGAN ANTARA KLASIFIKASI STROKE DENGAN GANGGUAN FUNGSI KOGNITIF PADA PASIEN STROKE
Authors: Nopia Dewi , Huzaifah Zaqyyah 
Published: December 2022

Stroke is the second leading cause of death in the world. Stroke is a vascular disorder caused by blockage or rupture of blood vessels in the brain, as a result of these conditions arises a clinical disorder resulting from damage to brain cells in certain parts. Symptoms can disrupt the process of mental activity or sublime cortical function including cognitive function. This study aims to determine the relationship between stroke classification with cognitive impairment in stroke patients. This type of research used in this study is a correlation analysis, with a cross-sectional design, a sample of 36 respondents according to criteria, using Chi-Square at α = 0.05. There is a relationship between the classification of stroke with cognitive impairment in stroke patients with a value of ρ value = 0,000.
Penyakit stroke merupakan penyebab kedua kematian di dunia. Stroke merupakan gangguan vaskular yang disebabkan oleh sumbatan atau pecahnya pembuluh darah diotak, akibat dari keadaan tersebut timbul suatu kelainan klinis akibat dari kerusakan sel otak pada bagian tertentu. Gejala dapat terganggunya proses aktifitas mental atau fungsi kortilal luhur termasuk fungsi kognitif. Penelitian ini bertujuan mengetahui hubungan antara klasifikasi stroke dengan gangguan fungsi kognitif pada pasien stroke. Jenis penelitian yang digunakan dalam penelitian ini adalah analisa korelasi, dengan rancangan cross-sectional, sampel 36 responden sesuai dengan kriteria, menggunakan Chi Square pada α = 0,05. Ada hubungan antara klasifikasi stroke dengan gangguan fungsi kognitif pada pasien stroke dengan nilai ρ value = 0,000.
GAMBARAN RESPONSE TIME PASIEN DI IGD RSI SITI AISYAH MADIUN
Authors: Sukamto Filia Icha 
Published: December 2022

Latar Belakang : Respon Time merupakan kecepatan dalam penanganan pasien, dihitung sejak pasien datang sampai dilakukan penanganan, waktu tanggap yang baik bagi pasien yaitu ≤ 5 menit. Semakin cepat pasien mendapat pertolongan definitif maka kemungkinan kesembuhan dan keberlangsungan hidup seseorang akan semakin besar, sebaliknya kegagalan response time di IGD dapat berakibat fatal berupa kematian atau cacat permanen. Tujuan : penelituian ini adalah untuk mengetahui gambaran response time pasien di IGD RSI Siti Aisyah Madiun. Metode : Jenis penelitian ini adalah diskriptif, dengan populasi pasien di IGD RSI Siti Aisyah Madiun. Sampel penelitian adalah sebagian pasien di IGD, teknik pengambilan sampling quota sampling dengan jumlah sampel 92 responden. Teknik pengambilan data dengan lembar observasi untuk response time dan kategori kegawatan pasien. Analisis data univariat dengan prosentase. Hasil : Hasil penelitian dari 92 responden didapatkan 72 (78,3%) responden ditangani dengan respon time cepat (< 5 menit) dan 20 (21,7%) responden ditangani dengan respon time lambat (> 5 menit). Kesimpulan : Berdasarkan hasil penelitian ini, maka disarankan agar petugas IGD senantiasa lebih sigap/tanggap dalam penanganan pasien gawat darurat agar tercapainya salah satu indikator mutu pelayanan di IGD yaitu respon time yang < 5 menit.
Gambaran Pengetahuan Perawat Tentang Metode ESI (Emergency Severity Index) DI Ruang Instalasi Gawat Darurat RSUD X
Authors: Muthmainnah Muthmainnah muthmainnah 
Published: December 2022

Latar Belakang: Masalah yang sering dijumpai Di rumah sakit adalah banyak pasien yang diberikan tindakan tidak sesuai dengan kriteria kegawatan dan kebijaksanaan prioritas yang wajib ditangani sang perawat, sebagai akibatnya bisa menyebabkan kepadatan. Sedangkan pelayanan IGD membutuhkan layanan yg cepat dan sempurna. salah satunya merupakan triase (Emergency Severity Index) ESI yang waktu ini diterapkan di Amerika menggunakan keunggulan identifikasi pasien lebih cepat, tepat serta tanpa perlu menunggu dokter triase. Tujuan: Penelitian ini bertujuan untuk mengidentifikasi gambaran tingkat pengetahuan perawat tentang metode ESI. Metode: Metode Penelitian ini menggunakan menggunakan Deskriptif dengan teknik Total Sampling. Sampel penelitian adalah 35 perawat yang bekerja di IGD RSUD X dan pengumpulan data dilakukan dengan lembar kuesioner. Hasil: Hasil yang didapatkan mayoritas perawat IGD didapatkan memiliki tingkat pengetahuan baik. sebagian besar perawat IGD RSUD X berusia 27-37 tahun dengan tingkat pengetahuan baik, perawat berpendidikan tinggi S1 dan D3 Keperawatan, sebagian besar jenis kelamin perawat ialah laki-laki, sebagian besar lama kerja yang dilakukan perawat ialah cepat (7 Jam) dan pengetahuan baik yang mengikuti pelatihan. Kesimpulan: Kesimpulan dari penilitian ini jika tingkat pengetahuan perawat baik tentang triage. Saran kepada perawat, yang masih belum memahami ESI, untuk mengikuti pelatihan dan lebih memahami bagaimana pengaplikasiannya.
Coronary artery disease as an independent predictor of short-term and long-term outcomes in patients with type-B aortic dissection undergoing thoracic endovascular repair
Authors: Li Wei , Luo Songyuan , Lin Wenhui , Su Sheng , Xu Wenmin , Hu Xiaolu , Liu Yuan , Huang Wenhui , Luo Jianfang , Zhou Yingling 
Published: December 2022

Background and aimsPrevious studies reported a high prevalence of concomitant coronary artery disease (CAD) in patients with Type B aortic dissection (TBAD). However, there is too limited data on the impact of CAD on prognosis in patients with TBAD. The present study aimed to assess the short-term and long-term impact of CAD on patients with acute or subacute TBAD undergoing thoracic endovascular aortic repair (TEVAR).MethodsWe retrospectively evaluated 463 patients with acute or subacute TBAD undergoing TEVAR from a prospectively maintained database from 2010 to 2017. CAD was defined before TEVAR by coronary angiography. Multivariable logistic and cox regression analyses were performed to evaluate the relationship between CAD and the short-term as well as long-term outcomes.ResultsAccording to the results of coronary angiography, the 463 patients were divided into the following two groups: CAD group (N = 148), non-CAD group (N = 315). In total, 12 (2.6%) in-hospital deaths and 54 (12%) all-cause deaths following a median follow-up of 48.1 months were recorded. Multivariable analysis revealed that CAD was an independent predictor of in-hospital major adverse clinical events (MACE) (odd ratio [OR], 2.33; 95% confidence interval [CI], 1.07–5.08; p = 0.033), long-term mortality [hazard ratio (HR), 2.11, 95% CI, 1.19–3.74, P = 0.011] and long-term MACE (HR, 1.95, 95% CI, 1.26–3.02, P = 0.003). To further clarify the relationship between the severity of CAD and long-term outcomes, we categorized patients into three groups: zero-vessel disease, single-vessel disease and multi-vessel disease. The long-term mortality (9.7 vs. 14.4 vs. 21.2%, P = 0.045), and long-term MACE (16.8 vs. 22.2 vs. 40.4%, P = 0.001) increased with the number of identified stenosed coronary vessels. Multivariable analysis indicated that, multi-vessel disease was independently associated with long-term mortality (HR, 2.38, 95% CI, 1.16–4.89, P = 0.018) and long-term MACE (HR, 2.79, 95% CI, 1.65–4.73, P = 0.001), compared with zero-vessel disease.ConclusionsCAD was associated with short-term and long-term worse outcomes in patients with acute or subacute TBAD undergoing TEVAR. Furthermore, the severity of CAD was also associated with worse long-term prognosis. Therefore, CAD could be considered as a useful independent predictor for pre-TEVAR risk stratification in patients with TBAD.
Long-term monitoring of pesticide residues on public sites: A regional approach to survey and reduce spray drift
Authors: Prechsl Ulrich E. , Bonadio Martina , Wegher Lino , Oberhuber Michael 
Published: December 2022

Plant protection strongly increased food safety and agricultural productivity, but with societal and environmental costs as the downside. Especially the contamination of non-target areas via spray drift represents an adverse side-effect. Residential zones and playgrounds are so-called “sensitive zones”, where spray drift is considered to have an increased potential for human health risk. To study the residue profile potentially associated with spray drift we analyzed data of a residue monitoring program in South Tyrol (Northern Italy). From 2018 to 2021, 39 playgrounds were analyzed multiple times per year for the presence and concentration of pesticide residues on grass samples. In a total of 399 samples, we identified 39 different residues deriving primarily from agricultural production. Mean concentration (0.0645 mg kg−1, SD: ± 0.1013 mg kg−1) and comparison to Maximum Residue Levels (MRLs) of food, revealed that 98.2% of the residues were in the range of MRLs and close to the analytical limit of quantification. We found that 6 out of 334 residues had relatively elevated concentrations clearly above the MRLs. Finally, a time series analysis of the study period revealed a significant decrease in the number of detected residues and their concentration by 72% and 78%, respectively. In the last year of this study, playgrounds showed on average 1.46 residues (SD: ± 1.252) with a mean concentration of 0.012 mg kg−1 (SD: ± 0.025), which is almost equal to the limit of detection (0.01 mg kg−1). The presented results demonstrate that 1) spray drift decreased significantly within 4-year and that 2) the introduced measures to decrease spray drift have been effective. Consequently, these results imply 3) that improved farming practice represents an important leverage point of further spray drift reduction.
Association between lactate-to-albumin ratio and 28-days all-cause mortality in patients with acute pancreatitis: A retrospective analysis of the MIMIC-IV database
Authors: Liu Qiang , Zheng Hai-Lun , Wu Man-Man , Wang Qi-Zhi , Yan Shan-Jun , Wang Meng , Yu Jiao-Jiao , Li Da-Peng 
Published: December 2022

ObjectiveThe Lactate-to-Albumin Ratio (LAR) has been applied as a new predictor in sepsis, heart failure, and acute respiratory failure. However, the role of LAR in predicting all-cause mortality in patients with acute pancreatitis has not been evaluated. Therefore, this study aimed to elucidate the correlation between LAR and 28-d all-cause mortality in patients with Acute Pancreatitis (AP).MethodsThis study is a retrospective cohort study with the data from the MIMIC-IV (v1.0) database. We included adult patients with acute pancreatitis who were admitted to the intensive care unit in the study. The primary outcome was to evaluate the ability of LAR to predict death at 28-d of hospital admission in patients with AP.ResultsA total of 539 patients with acute pancreatitis were included in this study. They were divided into a survival group (486 patients) and a death group (53 patients) according to whether they survived within 28-d of admission, and the mortality rate of patients within 28-d of admission was 9.8%. LAR was shown to be an independent predictor of all-cause mortality within 28-d of admission in patients with AP by multivariate COX regression analysis (HR, 1.59; 95% CI, 1.23 - 2.05; P &lt; 0.001). the Area Under the Curve (AUC) value for LAR was 74.26% (95% CI: 67.02% - 81.50%), which was higher than that for arterial blood lactate (AUC = 71.25%) and serum albumin (AUC = 65.92%) alone. It was not inferior even when compared to SOFA (AUC = 75.15%). The optimal cutoff value for separating the survival and death groups according to Receiver Operating Characteristic (ROC) was found to be 1.1124. plotting Kaplan-Meier analysis with this cutoff value showed that patients with LAR ≥ 1.1124 had significantly higher all-cause mortality within 28-d of admission than those with LAR &lt; 1.1124 (P &lt; 0.001). The final subgroup analysis showed no significant interaction of LAR with each subgroup (P for interaction: 0.06 - 0.974).ConclusionLAR can be used as an independent predictor of all-cause mortality in AP patients within 28-d of admission, with superior prognostic performance than arterial blood lactate or serum albumin alone.
Risk of liver dysfunction and non-alcoholic fatty liver diseases in people with hidradenitis suppurativa: A systematic review and meta-analysis of real-world evidences
Authors: Gau Shuo-Yan , Hsiao Yu-Ping , Liao Wen-Chieh , Ma Kevin Sheng-Kai , Wu Meng-Che 
Published: December 2022

BackgroundTo date, evidences with high evidence-level evaluating the association between liver diseases and hidradenitis suppurativa was lacking. Given that inconsistency exists in some of the previous observational studies, evaluating the prevalence of liver diseases in HS patients could potentially serve as a reference of future guidelines for HS comorbidity screening. The aim of the current study was to evaluate potential association between hidradenitis suppurativa and liver diseases and provide integrated evidences.MethodsA search in PubMed, Web of Science and Embase based on the syntaxes ‘‘hidradenitis suppurativa’’ or ‘‘acne inversa’’ with “comorbidities”, “liver diseases”, “fatty liver” or “hepatitis” was performed. Observational studies evaluating epidemiological association between hidradenitis suppurativa and the risk of all liver diseases, including specific diseases as non-alcoholic fatty liver disease, hepatitis B, hepatitis C were targeted to be extracted in this systematic review and meta-analysis.ResultsWithin the initial 702 records, there were finally 8 real-world observational studies extracted. Results suggest that patients with HS are associated with all liver diseases (OR= 1.50; 95% CI, 1.27, 1.76), non-alcoholic fatty liver disease (OR= 1.78; 95% CI, 1.28, 2.48) and hepatitis B (OR=1.48; 95% CI, 1.12, 1.94), but not hepatitis C (OR= 1.27; 95% CI, 0.78, 2.07). HS patients were associated with significantly increased risk of liver diseases, especially the risk of non-alcoholic fatty liver disease and hepatitis B.ConclusionsClinicians should be alert to the clinical relationship while caring people with hidradenitis suppurativa and the screening of liver function should be recommended to HS patients. Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022296034.