bluuebunny/crossref_metadata_2025_split huggingface dataset:
Definition and attributes of the emotional memory images underlying psychophysiological dis-ease
Authors: Hudson Matt , Johnson Mark I. 
Published: November 2022

BackgroundPreviously, we proposed a “Split-second Unlearning” model to explain how emotional memories could be preventing clients from adapting to the stressors of daily living, thus forming a barrier to learning, health and well-being. We suggested that these emotional memories were mental images stored inside the mind as ‘emotional memory images’ (EMIs).ObjectiveTo elaborate on the nature of these emotional memory images within the context of split-second learning and unlearning and the broader field of psychoanalysis, to initiate a conversation among scholars concerning the path that future healthcare research, practice, and policy should take.MethodA narrative review of the attributes of EMIs utilizing relevant and contentious research and/or scholarly publications on the topic, facilitated by observations and approaches used in clinical practice. Results: We propose a refined definition of EMIs as Trauma induced, non-conscious, contiguously formed multimodal mental imagery, which triggers an amnesic, anachronistic, stress response within a split-second. The systematic appraisal of each attribute of an EMI supports the idea that the EMI is distinct from similar entities described in literature, enabling further sophistication of our Split-second Unlearning model of psychophysiological dis-ease.ConclusionExploration of the concept of EMIs provides further insight on mechanisms associated with psychophysiological dis-ease and opportunities for therapeutic approaches.
Do parental cognitions during pregnancy predict bonding after birth in a low-risk sample?
Authors: Bohne Agnes , Nordahl Dag , Høifødt Ragnhild Sørensen , Moe Vibeke , Landsem Inger Pauline , Wang Catharina E. A. , Pfuhl Gerit 
Published: November 2022

Parental bonding to their infant is important for healthy parent-infant interaction and infant development. Characteristics in the parents affect how they bond to their newborn. Parental cognitions such as repetitive negative thinking, a thinking style associated with mental health issues, and cognitive dispositions, e.g., mood-congruent attentional bias or negative implicit attitudes to infants, might affect bonding.To assess the influence of cognitive factors on bonding, 350 participants (220 pregnant women and their partners) were recruited over two years by midwives at the hospital and in the communal health care services. Participants were followed throughout the pregnancy and until the infant was seven months old as a part of the Northern Babies Longitudinal Study. Both mothers and fathers took part. First, we measured demographics, repetitive negative thinking, attentional bias, and implicit attitudes to infants during pregnancy, as predictors of bonding two months postnatally. Second, we also measured infant regulatory problems, and depressive symptoms at two months postnatally as predictors of parents’ perception of infant temperament at five months. Robust regression analyses were performed to test hypotheses.Results showed that mothers and fathers differed on several variables. Parity was beneficial for bonding in mothers but not for fathers. Higher levels of mothers’ repetitive negative thinking during pregnancy predicted weaker bonding, which was a non-significant trend in fathers. For fathers, higher education predicted weaker bonding, but not for mothers. Mothers’ perception of their infant temperament at five months was significantly affected by bonding at two months, but for fathers, their depressive symptoms were the only significant predictor of perceived infant temperament.In conclusion, for mothers, their relationship with their infant is essential for how they experience their infant, while for fathers their own wellbeing might be the most important factor. Health care providers should screen parents’ thoughts and emotions already during pregnancy to help facilitate optimal bonding.
Transcutaneous electrical acupoint stimulation combined with electroacupuncture promotes rapid recovery after abdominal surgery: Study protocol for a randomized controlled trial
Authors: Li Hao , Du Chen , Lu Lingyun , Hu Xiangyun , Xu Huiming , Li Ning , Liu Hong , Wen Qian 
Published: November 2022

IntroductionThe most frequent complications after abdominal surgery include a decrease or loss of appetite, abdominal distension, abdominal pain caused by reduced gastrointestinal motility, anal arrest with intestinal distension and defecation, and nausea and vomiting due to anesthetic and opioid analgesic administration. These complications severely affect postoperative recovery, prolong hospital stay, and increase the financial burden. The objective of this study is to investigate the efficacy and safety of three acupoint stimulation modalities (electroacupuncture [EA], transcutaneous electrical acupoint stimulation [TEAS], and transcutaneous acupoint electrical stimulation combined with EA [TEAS+EA]), and two EA instrument waveforms (continuous wave and dilatational wave) for rapid recovery after abdominal surgery.Methods and analysisA total of 560 patients will be recruited and randomly allocated to receive one of the following seven interventions: continuous wave EA, continuous wave TEAS, continuous wave TEAS + EA, dilatational wave EA, dilatational wave TEAS, dilatational wave TEAS + EA, and a control. For this study, continuous waves at 2 Hz, and dilatational waves at 2/50 Hz would be selected. The points to be stimulated by EA are the bilateral Neiguan (PC6), Hegu (LI6), Zusanli (ST36), Shangjuxu (ST37), and Xiajuxu (ST39), and TEAS would stimulate the bilateral Liangmen (ST21) and Daheng (SP15). The control group will neither receive EA nor TEAS. All patients will undergo an enhanced recovery plan after surgery and be provided with standardized perioperative management. Treatment will start on the first postoperative day and be administered once daily in the morning until the patient regains spontaneous bowel movements and can tolerate oral intake of solid food. The primary outcome is a composite of time to first defecation and time to tolerance of a solid diet. Secondary outcomes include time to first exhaustion; time of first defecation; time of tolerance of a solid diet; time to the first ambulation; length of hospital stay from surgery to discharge; visual analog scale score for postoperative daily pain, nausea, and vomiting; incidence of postoperative complications; and treatment acceptability.DiscussionThis study will compare the efficacy and safety of three acupoint stimulation methods and two EA instrument waveforms for rapid recovery after abdominal surgery.Trial RegistrationChinese Clinical Trial Registry (http://www.chictr.org.cn), ChiCTR2100043883.
Gender differences in association of urbanization with psychological stress in Chinese adults: A population-based study
Authors: Li Dianjiang , Ruan Yuhui , Kang Qi , Rong Chao 
Published: November 2022

ObjectiveTo investigate the gender-specific associations between exposure to urbanization and psychological stress in China experiencing rapid urbanization.MethodsData were obtained from the 2015 China Health and Nutrition Survey. A total of 4,388 men and 5,098 women aged at least 18 years were obtained from 288 communities across 12 provinces and municipalities. Tertiles of the urbanization index, summarizing 12 urbanization dimensions at the community level, were used to define low, medium, and high levels of urbanization. The psychological stress was measured based on the 10-item Perceived Stress Scale. The gender-stratified multilevel analysis (Level-1: Individuals, Level-2: Communities, and Level-3: provinces/municipalities) was used to estimate the association between exposure to urbanization and psychological stress.ResultsAfter controlling for age, education status, marital status, work status, household income per capita, current smoking, alcohol drinking, sleep duration, BMI, and chronic conditions, the urbanization index was negatively associated with psychological stress in women (Ptrend = 0.017) but not men (Ptrend = 0.476). More specifically, a one-standard deviation increase in the score of community population density (β = −0.329, P = 0.329), modern markets (β = −0.247, P = 0.044), education (β = −0.448, P = 0.002), and housing (β = −0.380, P = 0.005) was negatively associated with psychological stress only in women, separately.ConclusionOur data revealed that living in the most urbanized communities is associated with lower levels of psychological stress for women but not men. Thus, this study can help empower decision-makers to accurately target vulnerable communities and plan effective strategies to address psychological outcomes.
Using genetic instruments to estimate the causal effect of hormonal reproductive factors on osteoarthritis
Authors: Wang Bingran , Wu Junhua , Li Han , Jin Xiaoyan , Sui Cong , Yu Zhen 
Published: November 2022

ObjectivesHormonal reproductive factors have been considered to play an important role in the etiology of osteoarthritis (OA). We performed Mendelian randomization (MR) to examine whether a causal effect existed between them.MethodsMR was performed by using publicly released genome-wide association study (GWAS) summary statistics to estimate the causal associations of three relevant exposures, including age at menarche (AAM), age at natural menopause (ANM) and age at first birth (AFB), with the risk of OA. We employed several MR methods, including inverse-variance weighted (IVW), MR-Egger regression, weighted median and weighted mode, to estimate the causality. We performed a sensitivity analysis by manually pruning pleiotropic variants associated with the known confounder body mass index (BMI).ResultsThe instrumental variables that achieved genome-wide significance, including 349 AAM single nucleotide polymorphisms (SNPs), 121 AAM SNPs, 54 ANM SNPs, and 10 AFB SNPs, were incorporated into the operation. IVW analysis indicated that each additional year in AFB was associated with a decreasing risk of hip and/or knee OA and overall OA (hip and/or knee OA: OR = 0.79, 95% CI: 0.64–0.93, P = 1.33 × 10−3; overall OA: OR = 0.80, 95% CI: 0.68–0.92, P = 1.80 × 10−4). In addition, our results suggested that AAM exerted a causal effect on knee OA in an unfavorable manner (OR = 0.86, 95% CI: 0.76–0.95, P = 1.58 × 10−3). After accounting for the effect of BMI, the causal effect association between AFB and hip and/or knee OA was also examined (IVW: OR = 0.78, 95% CI: 0.66–0.92, P = 3.22 × 10−3).ConclusionOur findings add a growing body of evidence surrounding the unfavorable effects of early AFB on OA risk, suggesting the essential for relevant health problem management in susceptible populations.
The Immunological Epigenetic Landscape of the Human Life Trajectory
Authors: Juříčková Iva , Hudec Michael , Votava Felix , Vosáhlo Jan , Ovsepian Saak Victor , Černá Marie , O’Leary Valerie Bríd 
Published: November 2022

Adaptive immunity changes over an individual’s lifetime, maturing by adulthood and diminishing with old age. Epigenetic mechanisms involving DNA and histone methylation form the molecular basis of immunological memory during lymphocyte development. Monocytes alter their function to convey immune tolerance, yet the epigenetic influences at play remain to be fully understood in the context of lifespan. This study of a healthy genetically homogenous cohort of children, adults and seniors sought to decipher the epigenetic dynamics in B-lymphocytes and monocytes. Variable global cytosine methylation within retro-transposable LINE-1 repeats was noted in monocytes compared to B-lymphocytes across age groups. The expression of the human leukocyte antigen (HLA)-DQ alpha chain gene HLA-DQA1*01 revealed significantly reduced levels in monocytes in all ages relative to B-lymphocytes, as well as between lifespan groups. High melting point analysis and bisulfite sequencing of the HLA-DQA1*01 promoter in monocytes highlighted variable cytosine methylation in children and seniors but greater stability at this locus in adults. Further epigenetic evaluation revealed higher histone lysine 27 trimethylation in monocytes from this adult group. Chromatin immunoprecipitation and RNA pulldown demonstrated association with a novel lncRNA TINA with structurally conserved similarities to the previously recognized epigenetic modifier PARTICLE. Seeking to interpret the epigenetic immunological landscape across three representative age groups, this study focused on HLA-DQA1*01 to expose cytosine and histone methylation alterations and their association with the non-coding transcriptome. Such insights unveil previously unknown complex epigenetic layers, orchestrating the strength and weakening of adaptive immunity with the progression of life.
USO DE ABONO ORGÁNICO Y MINERAL SOBRE LA MORFOLOGÍA Y RENDIMIENTO DEL CULTIVO DE SOYA (Glycine max L. Merrill) PANORAMA P29
Authors: Durán Mera Christian Alejandro , Carrillo Zenteno Manuel Danilo , Delgado Párraga Alex Gabriel , López Bosquez Jonathan Bismar , Zambrano Bosquez Juan Pablo 
Published: November 2022

La soya es una leguminosa de origen asiático, su composición es de alto contenido proteínico, consumida como fuente de nutrientes en la alimentación humana y animal. Este cultivo necesita absorber una importante cantidad de nutrientes para su crecimiento y rendimiento. La falta de una adecuada fertilización hace que los productores soyeros no obtengan la producción y calidad esperada. El objetivo de la investigación fue evaluar el comportamiento morfológico y rendimiento de la variedad de soya Panorama P29 mediante el uso de abono orgánico y mineral. Se utilizó un diseño de bloques completamente al azar con cuatro tratamientos y tres repeticiones, para la comparación de medias se empleó la prueba de Duncan al P≤ 0,05. Los tratamientos utilizados fueron: Testigo, abono orgánico, N-P-K y N-P-K-S, las variables evaluadas fueron: altura de planta y carga, días a floración, maduración y cosecha, número de vainas, semillas por plantas y rendimiento. Los resultados obtenidos demostraron que no hubo diferencia estadísticas en la morfología de la planta a excepción de la variable de altura de carga, el mayor rendimiento fue con la aplicación mineral N-P-K-S con un promedio de 2284,33 kg ha-1. Con el uso del abono orgánico se logró obtener 2 t ha-1 provocando un incremento en el rendimiento del cultivo.
Efeito agudo do exercício resistido dinâmico realizado abaixo e acima do limiar de lactato sanguíneo sobre frequência cardíaca e modulação cardíaca parassimpática de mulher hipertensa e diabética
Authors: Britto Angélica Cristiane da Cruz , Chagas Eduardo Federighi Baisi , Rodrigues Pedro Henrique , Cogo Pauline Romualdo , Froio Juliana Lôbo , Silva Cristiano Sales da , Quitério Robison José 
Published: November 2022

Introdução: Diabetes Mellitus tipo 2 pode causar alterações do sistema nervoso autônomo levando a prejuízos nas respostas durante o exercício fisico. Uma das formas de avaliar esse sistema é através da frequencia cardíaca (FC) e da variabilidade da frequencia cardíaca (VFC). O limiar de lactato (LL) sanguíneo é momento metabólico extremamente útil e muito utilizado para prescrição individualizada da intensidade do exercício aeróbio. Objetivo: Investigar o efeito agudo do exercício físico resistido dinâmico realizado abaixo e acima do LL sobre a frequência cardíaca e a modulação cardíaca parassimpática de mulher hipertensa e diabética. Material e método: A amostra foi composta por uma mulher de 55 anos hipertensa e diabética tipo 2. O limiar de lactato foi determinado durante o exercício de extensão de joelho (mesa romana) e aplicado dois testes: um com 10 % abaixo e outro com 10% acima do LL, com duração de um minuto cada um, mantendo respiração espontânea e sem apneia. Resultados: FC repouso = 68 e 67 bpm; FC máxima durante exercício = 86 e 93 bpm; % da FC de reserva = 18,5 e 26,3; RMSSD repouso = 13,5 e 18,8 ms; RMSSD exercício = 9,0 e 10,6; SD1 repouso = 9,7 e 13,4; SD1 exercício = 6,4 e 7,6. Conclusão: Um minuto de exercício de extensão do joelho a 20% da carga máxima causa sobrecarga cronotrópica 18,5% e diminuição da modulação cardíaca parassimpática em 33%. Na intensidade com 40% da carga máxima, acima do LL, ocorre, aumento e diminuição adicional na sobrecarga cronotrópica (7,75) e modulação parassimpática cardíaca (10%), respectivamente, de mulher hipertensa e diabética
Degeneração macular relacionada à idade: uma visão geral e atualizações
Authors: Pina Guilherme Cristovam , Barreto Lara Marques , Vieira Raquel Morales , Tomaz Paloma Nicolau , Teixeira João Pedro Cavalcante Roriz , Ferreira Aline Rabelo , Fraga Murillo Sidney Garcia , Santos Juliene César dos , Ribeiro Gabriella Reis de Barros , Couto Liana Aguiar , Sena Miguel Ângelo Amorim , Basílio Isabela Gomes , Almeida Ana Laura Carvalho , Pina Lais Cristovam , Portilho João Vitor Miranda , Jayme Brenda Cavalieri 
Published: November 2022

A degeneração macular relacionada à idade é um importante problema de saúde pública mundial, sendo o principal distúrbio ocular causador de cegueira entre a população idosa. O objetivo desse estudo foi analisar de forma geral os principais aspectos atuais relacionados à degeneração macular relacionada à idade e para a sua confecção, foram realizadas buscas em bases de dados e selecionados inicialmente 22 artigos, dentre os quais 13 se enquadraram nos critérios pré-estabelecidos. A doença afeta a mácula, região central da retina, responsável pela acuidade visual e pela visão em cores, e seu desenvolvimento está associado a fatores ambientais, genéticos e metabólicos. A degeneração macular relacionada à idade se divide em forma seca ou atrófica e úmida ou exsudativa ou neovascular. Para a forma seca, ainda não há consenso de manejo terapêutico, visto que uma vez instalada a atrofia observada na doença, não há reversão, sendo seu manejo focado principalmente no retardo da progressão para a forma úmida da doença. Agentes anti-VEGF foram amplamente estudados no tratamento da forma exsudativa, sendo que sua aplicação mensal, a cada dois ou a cada três meses demonstrou resultados positivos na melhora da acuidade visual. Novos estudos clínicos ainda estão sendo conduzidos e espera-se obter novas formas de terapias para um melhor prognóstico da doença num futuro próximo.
Microfabrication of polydimethylsiloxane–parylene hybrid microelectrode array integrated into a multi-organ-on-a-chip
Authors: Zhang Dongxiao , Yang Jiandong , Hirai Yoshikazu , Kamei Ken-ichiro , Tabata Osamu , Tsuchiya Toshiyuki 
Published: November 2022

Abstract
Multi-organ-on-a-chip devices have attracted extensive attention because they hold great potential for advancing drug discovery and development by recapitulating human physiological conditions. However, they often lack on-chip analytical technologies for the in situ non-invasive real-time monitoring of organ tissue responses to pharmaceutical compounds over extended durations. Here, we introduce the microfabrication of a multi-organ-on-a-chip by integrating two indispensable components into a polydimethylsiloxane (PDMS)-based microfluidic device: a pneumatic-actuated micropump to generate a circulation flow for organ-organ interaction and a parylene-insulated microelectrode array (MEA) for electrophysiological analysis. We demonstrated that the pumping performance of the micropump was sufficient for recapitulating the metabolite interaction, and the measured impedance magnitude was comparable to that of state-of-the-art MEA devices. The experimental results suggest that the present microfabrication has potential applications such as the measurement of electrophysiological parameters under recapitulating metabolite interaction, enabling more comprehensive drug testing in vitro.
Ultrafast operation of Si thermo-optic switch using differential control method
Authors: Iino Kohei , Kita Tomohiro 
Published: November 2022

Abstract
To realize fast switching of a few μs and low-power consumption, we apply a differential control method to a thermo-optic Mach–Zehnder interferometer optical switch loaded with a direct-current injection-type phase shifter using multimode interference. We achieve ultrafast switching of several tens of ns, which is considerably higher than the conventional switching speed. With differential control, we demonstrate extremely fast optical switching with

τ
rise

= 36 ns and

τ
fall

= 24 ns. This method can be widely applied to similar devices and can contribute significantly to the speedup of other thermo-optic switches.
Training Website Creation and Management for Efforts to Improve School Media Literacy at SMP Negeri 4 Bayongbong
Authors: Haryadi Ardi Mulyana , Asmaniah Zainah , Julianto Cecep Dudung , Ipan Ipan , Riawati Riawati 
Published: November 2022

Abstract
Sekolah Menengah Pertama Negeri (SMP N) 4 Bayongbong is a secondary school located in the Cilimus area, Bayongbong. Based on observations and interviews that have been conducted, there are problems at the school, namely regarding the lack of knowledge about media literacy and management of website content from teachers. The purpose of this activity is to provide training in website content creation and media literacy so that schools can independently manage the school website. The service activities are divided into several stages, namely need assessment, training on website content and media literacy, and follow-up to teachers of SMP N 4 Bayongbong. The result of this activity is that teachers can understand how to manage website content and get increased media literacy.

Abstrak
Sekolah Menengah Pertama Negeri (SMPN) 4 Bayongbong adalah sekolah lanjutan pertama yang berada di daerah Cilimus Bayongbong, Garut. Berdasarkan observasi serta wawancara yang telah dilakukan, terdapat permasalahan di Sekolah tersebut, yaitu mengenai kurangnya pengetahuan mengenai literasi media serta pengelolaan konten website dari para guru di sekolah tersebut. Tujuan kegiatan ini adalah memberikan pelatihan pembuatan konten website maupun literasi media agar sekolah dapat mandiri dalam mengelola website sekolah. Kegiatan pengabdian terbagi menjadi beberapa tahap, yaitu pengelompokan, pelatihan konten website dan literasi media, serta follow up kepada guru SMPN 4 Bayongbong. Hasil kegiatan ini adalah guru-guru dapat memahami mengenai cara pengelolaan konten website serta mendapatkan peningkatan literasi media.