bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human drone interaction in delivery of medical supplies: A scoping review of experimental studies
Authors: Stephan Franziska , Reinsperger Nicole , Grünthal Martin , Paulicke Denny , Jahn Patrick 
Published: April 2022

Background
The COVID-19 pandemic, ageing populations and the increasing shortage of skilled workers pose great challenges for the delivery of supplies for people with and without care needs. The potential of drones, as unmanned air vehicles, in healthcare are huge and are discussed as an effective new way to delivery urgent medicines and medical devices, especially in rural areas. Although the advantages are obvious, perspectives of users are important particularly in the development process. Investigating human drone interaction could potentially increase usefulness and usability. The present study aims to perform a systematic scoping review on experimental studies examining the human drone interaction in deliveries of drugs and defibrillators.

Methods
Two databases (MEDLINE and CINAHL) and references of identified publications were searched without narrowing the year of publication or language. Studies that investigated the human drone interaction or medical delivery with drones in an experimental manner were included (research articles). All studies that only simulated the delivery process were excluded.

Results
The search revealed 83 publications with four studies being included. These studies investigated the user experience of drone delivered defibrillators, but no study was identified that investigated the human drone interaction in the delivery of drugs. Three categories of human drone interaction were identified: landing, handover, and communications. Regarding landing and handover, the most important issue was the direct physical contact with the drone while regarding communications users need clearer instructions about drone´s direction, sound and look like.

Discussion
The identified studies used technology-driven approaches by investigating human drone interaction in already existing technologies. Users must become integral part of the whole development process of medical drone services to reduce concerns, and to improve security, usability and usefulness of the system. Human drone interaction should be developed according to the identified categories of human drone interaction by using demand- and technology-driven approaches.
Development of core outcome sets for clinical trials in temporomandibular disorders: A study protocol
Authors: Ferreira Natália dos Reis , Marto Carlos Miguel Machado , de Oliveira Aleli Tôrres , Rodrigues Maria João , DosSantos Marcos Fabio 
Published: April 2022

BackgroundTemporomandibular Disorder (TMD) is a generic term applied to describe musculoskeletal disorders that affect the temporomandibular joint (TMJ), the masticatory muscles and the related structures. TMD comprises two groups of disorders, namely intra-articular TMD and masticatory muscle disorders. There is still difficulty in establishing the effectiveness of different therapeutic modalities for TMD with robust evidence, despite the large volume of publications in the area. The lack of outcomes standardization may represent a limiting factor in the search for scientific evidence.ObjectiveThis study aims to develop a core outcome sets (COS) for clinical trials in intra-articular TMD and masticatory muscle disorders.MethodsThe protocol for determining the COS-TMD will consist of three phases: 1. Synthesis of TMD Management Intervention Outcomes. The identification of outcomes will be carried out through a systematic review, which will include randomized clinical trials that evaluated the effectiveness of interventions used in TMD management. 2. Through a two-round international Delphi survey, the list of outcomes will be scored by three panels of stakeholders. 3. A representative sample of key stakeholders will be invited to participate in a face-to-face meeting where they can discuss the results of the Delphi survey and determine the final core set.ConclusionsThe implementation of this protocol will determine the COS-TMD, which will be made available for use in all TMD clinical studies. The use of COS when planning and reporting TMD clinical trials will reduce the risk of publication bias and enable proper comparison of results found by different studies.
Loop-mediated isothermal amplification (LAMP) colorimetric phenol red assay for rapid identification of α0-thalassemia: Application to population screening and prenatal diagnosis
Authors: Jomoui Wittaya , Srivorakun Hataichanok , Chansai Siriyakorn , Fucharoen Supan 
Published: April 2022

BackgroundIdentification of α0-thalassemia (SEA and THAI deletions) is essential in preventing and controlling of severe thalassemia diseases. We have developed the LAMP colorimetric assays for the detection of these two thalassemia defects and validated them in population screening and prenatal diagnosis.MethodsThree LAMP colorimetric assays specific for α0-thalassemia (SEA deletion), α0-thalassemia (THAI deletion) and normal DNA sequence were developed. These assays were validated on 341 subjects who had initial thalassemia screening positive and various thalassemia genotypes. Prenatal diagnosis of α0-thalassemia (SEA deletion) was done on 33 fetuses at risk of having Hb Bart’s hydrops fetalis syndrome.ResultsThe LAMP colorimetric assays for α0-thalassemia (SEA and THAI deletions) could be clearly interpreted by naked eyes. The assay for α0-thalassemia (SEA deletion) showed a 100% (62/62 x 100) sensitivity and 98.2% (274/279 x 100) specificity whereas, that of the α0-thalassemia (THAI deletion) showed 100% (1/1 x 100) sensitivity and 99.7% (339/340 x 100) specificity. We obtained a 100% concordant prenatal diagnosis results using LAMP assays of α0-thalassemia (SEA deletion) in 33 fetuses as compared to the conventional PCR analysis.ConclusionsThe LAMP colorimetric assays developed are simple, rapid, and do not require sophisticated equipment. Inclusion of the LAMP tests in the existing screening protocol significantly reduce the screening cost and the molecular analysis workload, which should prove useful in the prevention and control program of hemoglobinopathies in the region.
Influence of warm acupuncture on gut microbiota and metabolites in rats with insomnia induced by PCPA
Authors: Yu Hong , Yu Hui , Si Lengge , Meng Husileng , Chen Wensheng , Wang Zhanli , Gula A. 
Published: April 2022

BackgroundInsomnia is the most common of the sleep disorders. Current pharmacotherapy treatment options are usually associated with adverse effects and withdrawal phenomena. Therapeutic alternatives with a more favorable safety profile for patients are needed. Mongolian medical warm acupuncture (MMWA) is an emerging therapeutic option for treating insomnia. However, the underlying mechanisms responsible for the anti-insomnia efficacy of the MMWA remain unclear. This study aims to investigate the effect of the MMWA on the alterations of the gut microbiota and serum metabolome in rats with insomnia.ResultsWe found that the relative abundances of gut bacteria and the concentrations of several serum metabolites were obviously altered in PCPA-induced insomnia rats. The MMWA treatment exerted an anti-insomnia effect. In addition, the dysbiosis of the gut microbiota and the serum metabolites were ameliorated by the MMWA. Correlation analysis between the gut microbiota and metabolites suggested that the levels of Amide c18, Benzoyl chloride, Cytosine, and N, n-dimethylarginine were positively correlated with the relative abundance ofClostridium XlVaandBlautia, which characterized the insomnia rats. KEGG enrichment analysis identified the cAMP signaling pathway involving anti-insomnia effect of the MMWA. Moreover, the MMWA intervention significantly increased contents of butyrate in feces, while effectively inhibited the expression level of GAT-1 in brain tissues.ConclusionThis study reveals that the MMWA intervention might have a major impact on the modulation of host gut microbiota and metabolites, which in turn have a crucial role in the regulation of the host’s signaling pathways associated with insomnia. The present study could provide useful ideas for the study of the intervention mechanisms of the MMWA in insomnia rat models.
O TRABALHO DOCENTE EM EDUCAÇÃO FÍSICA NO CONTEXTO DA CONSTRUÇÃO IMPOSITIVA DO ENSINO REMOTO EMERGENCIAL
Authors: Da Costa Brasil de Borba Jônatas , Santos Kuhn Simone , Do Nascimento Colvara Marcela 
Published: April 2022

Este artigo tem o objetivo de refletir sobre as mudanças ao trabalho docente em Educação Física desenvolvido por professores e professoras da Rede Federal e Estadual de Educação do Rio Grande do Sul a partir da implementação de alternativas ao ensino presencial. Para isso, construímos o seguinte questionamento: como as mudanças ocorridas a partir da Pandemia COVID-19 atravessou e modificou o trabalho docente em Educação Física? Para isso, nos valemos de pesquisas em curso e analise de publicações do campo acadêmico pedagógico. Entendemos que as transformações impostas pela forma de trabalho desenvolvido a partir da suspensão das aulas potencializou e intensificou demandas pré-existentes na classe docente.
Artificial Intelligence for Education, Proctoring, and Credentialing in Cardiovascular Medicine
Authors: Krajcer Zvonimir 
Published: April 2022

Artificial intelligence and machine learning are rapidly gaining popularity in every aspect of cardiovascular medicine. This review discusses the past, present, and future of artificial intelligence in education, remote proctoring, credentialing, research, and publication as they pertain to cardiovascular procedures. This review describes the benefits and limitations of artificial intelligence and machine learning and the exciting potential of integrating advanced simulation, holography, virtual reality, and extended reality into disease diagnosis and patient care, as well as their roles in cardiovascular research and education. Nonetheless, much of the available data resides in electronic medical records or within industry-sponsored proprietary programs that are not compatible or standardized for current clinical application.
Many areas in cardiovascular medicine would benefit from the introduction or increased use of artificial intelligence. Web-based artificial intelligence applications could be used to address unmet needs for education, on-demand procedural proctoring, credentialing, and recredentialing for interventionists and physicians in remote locations. Further progress in artificial intelligence will require further collaboration among computer scientists and researchers in order to identify and correct the most relevant problems and to implement the best data-based approach to achieving this goal. The future success of artificial intelligence in cardiovascular medicine will depend on the degree of collaboration between all pertinent experts in this field. This will undoubtedly be a prolonged, stepwise process.
TINGKAT PENDIDIKAN, KEJADIAN DIARE DAN RISIKO KURANG ENERGI KRONIS PADA WANITA USIA SUBUR DI PROVINSI-PROVINSI KEPULAUAN DI INDONESIA (ANALISIS DATA RISKESDAS 2018)
Authors: Putri Fikria Maharani , Jus'at Idrus , Sitoayu Laras , Melani Vitria , Palupi Khairizka Citra 
Published: April 2022

Latar Belakang: Kekurangan Energi Kronik (KEK) yang diukur dengan Lingkar Lengan Atas (LiLA) merupakan salah satu keadaan malgizi yang terjadi pada wanita usia subur (WUS). Banyak faktor yang mempengaruhi kondisi ini, beberapa yang diteliti dalam penelitian ini yaitu tingkat pendidikan dan diare.Tujuan: Mengetahui hubungan tingkat pendidikan dan diare terhadap lingkar lengan atas WUS 15-19 tahun di provinsi-provinsi kepulauan di Indonesia (NTT, NTB, Maluku, Maluku Utara dan Kepulauan Riau).Metode: Penelitian ini menggunakan desain cross sectional dengan 3.838 WUS 15-19 tahun. Analisis data sekunder dari Riskesdas 2018 kemudian diolah pada Juni 2021 oleh peneliti. Data dianalisa menggunakan uji Regresi Linier Berganda Variabel Dummy dan uji Logistik Regresi untuk melihat apakah tingkat pendidikan dan diare merupakan faktor yang mempengaruhi risiko KEK.Hasil: Ada hubungan antara tingkat pendidikan dengan LiLA (p=0,001) dan berisiko terjadinya KEK pada WUS. Wanita usia subur dengan pendidikan rendah (SD dan SMP) yang pernah menderita diare lebih berisiko KEK dari WUS dengan pendidikan lebih tinggi (SMA). Walaupun demikian, tidak ada hubungan antara diare dengan LiLA (p=0,846) dan tidak mempengaruhi risiko KEK pada WUS.. WUS dengan pendidikan rendah (SD dan SMP) yang pernah menderita diare memiliki ukuran LiLA lebih kecil dari WUS dengan pendidikan lebih tinggi (SMA).Simpulan : WUS dengan pendidikan rendah (SD dan SMP) yang pernah menderita diare cenderung lebih berisiko KEK
ANALISIS ASUPAN ZAT BESI HEME DAN NON HEME, VITAMIN B12 DAN FOLAT SERTA ASUPAN ENHANCER DAN INHIBITOR ZAT BESI BERDASARKAN STATUS ANEMIA PADA SANTRIWATI
Authors: Ayuningtyas Ika Nanda , Tsani A Fahmy Arif , Candra Aryu , Dieny Fillah Fithra 
Published: April 2022

heme. Ketersediaan sumber zat besi yang terbatas menjadi salah satu penyebab tingginya prevalensi anemia pada santriwati di pondok pesantren.Tujuan: Mengetahui perbedaan asupan zat besi hem dan non hem, vitamin B12 dan folat, serta asupan enhancer dan inhibitor zat besi berdasarkan status anemia pada santriwati.Metode: Penelitian ini menggunakan desain cross-sectional dengan 58 santriwati berusia 15-19 tahun yang dipilih dengan metode purposive sampling. Subjek dibagi menjadi dua kelompok yaitu anemia dan non anemia. Data Penilaian asupan zat besi, hem, dan non hem menggunakan kuesioner IRONIC FFQ sedangkan asupan vitamin B12, folat, enhancer (protein, vitamin C, zinc) dan inhibitor (fitat, tanin, kalsium) menggunakan kuesioner SQFFQ. Pengukuran kadar Hb dengan metode cyanmethemoglobin. Analisis bivariat menggunakan uji Independent T-test dan Mann Whitney.Hasil: Sembilan puluh satu koma empat persen asupan zat besi subjek tergolong kurang. Asupan zat besi pada kelompok non anemia lebih besar dari kelompok anemia. Pada kelompok anemia rerata asupan hem sebesar 0,4 mg dan asupan non hem sebesar 5,58 mg. Sedangkan pada kelompok non anemia, rerata asupan hem sebesar 0,94 mg dan asupan non hem sebesar 9,04 mg. Terdapat perbedaan yang signifikan antara asupan zat besi total (p<0,001), besi hem (p<0,001) , besi non hem (p<0,001), serta asupan zinc, protein, vitamin B12 dan kalsium (p<0,05) berdasarkan status anemia.Simpulan: Terdapat perbedaan yang signifikan antara asupan zat besi hem, besi non hem, vitamin B12, protein, zinc dan kalsium berdasarkan status anemia.
The emergence of bunched vowels from retroflex approximants in endangered Dardic languages
Authors: Hussain Qandeel , Mielke Jeff 
Published: April 2022

Abstract
Kalasha, an endangered Dardic (Indo-Aryan) language, contrasts a rich set of rhotic vowels, a vowel type, which is found in less than 1% of the world’s languages. The acoustic and articulatory correlates of rhotic vowels, and their development and geographical distribution in Kalasha and other Indo-Iranian languages are still poorly understood. The current study brings together typological data on retroflex approximants and flaps in 192 Indo-Iranian language varieties, and phonetic data on rhotic vowels and retroflex approximants in endangered Dardic (Kalasha and Dameli) and Nuristani (Kamviri and Eastern Kataviri) languages. The phylogeography of retroflex approximants and flaps indicates that rhotic vowels are prevalent in those areas of South Asia where retroflex approximants are in abundance. Specifically, the development of rhotic vowels in Kalasha may have been amplified by the presence of retroflex approximants in neighboring Nuristani languages. We show that phonetically the rhotic sounds in the two Dardic languages are produced with a bunched tongue shape, whereas the retroflex approximants in Nuristani languages are produced with the raising of the tongue tip.
Sublimation of a volatile component as a possible mechanism for thermoelectric material degradation
Authors: Gorskyi Petro 
Published: April 2022

A physical model of the sublimation of a volatile component from a thermoelectric material has been developed. On its basis, two versions of the mathematical description of the degradation process of thermoelectric material are presented. The first of them takes into account only the diffusion of tellurium as a volatile impurity to the evaporation surface, on which the pressure and, consequently, the concentration of atoms of the volatile component are considered to be known. The second explicitly takes into account the volatility of the evaporating component and, hence, the boundary flux on the evaporation surface. In both cases, an analytical solution of the one-dimensional diffusion equation is obtained taking into account the presence of a temperature gradient along the length of the leg. Further, by computer methods in the Mathcad environment, the time dependence of the thickness of the layer with a reduced concentration of the volatile component and the nature of the distribution of the concentration of this component in it was determined. On this basis, the degradation time of thermoelectric material due to the loss of volatile components is estimated and the requirements for the protective coating of thermoelectric branches are established.
Investigation on the solubility, growth, vibrational characteristics and linear optical constants of potassium bisulphate single crystals
Authors: Thilaga K. , Selvarajan P. , Kader S. M. Abdul 
Published: April 2022

The present research report describes on the characterization of potassium bisulfate or potassium hydrogen sulphate (KHS) single crystals grown using slow evaporation method at room temperature. The KHS crystal was found to be crystallizing in centrosymmetric orthorhombic structure. The existence of different functional groups in the crystal was assured by FTIR investigation. The optical transmittance of the KHS crystal was investigated using the UV visible spectrum. Moreover, the band gap energy as well as optical constants including dielectric constant, reflectance, extinction coefficient, optical conductivity, refractive index, and electrical conductivity was reported.
The Importance of Human Capital in The Formation of Capable United Territorial Communities of Ukraine
Authors: Sokolska Tetyana , Dzhegur Gennadii , Polishchuk Svitlana , Lobachova Svetlana 
Published: April 2022

Abstract. The study examined the modern state of human capital formation, accumulation and use in Ukraine and assessed it to be ambiguous. On the one hand, the improvement of certain qualitative characteristics such as increasing amount of the population with higher education, computer literacy, its ability to work in a market environment and run business are observed. On the other hand, destructive processes are taking place which especially true for the rural population (shortage of highly qualified personnel, depreciation of labor, unemployment, low level of innovations introduction and implementation, increasing poverty, reducing life expectancy, mortality exceeding birth rate, migration, unequal opportunities for education and health services, lack of infrastructure, opportunities for cultural development of cinema, theater, youth recreation areas, etc).
The survey was conducted to find out the degree to which life quality had changed after unification and it reveals that only 10% of respondents in Kyiv oblast wanted their children to live in the community, while in Cherkasy oblast no one wanted to. In addition, 53% of the respondents considered the state of community development unsatisfactory, and only 17% considered it to be good.
The study also reveals the low level of competence of local authorities heads and their executive committees, especially in the use of modern tools of public administration. However, significant reserves for human capital development have been identified, namely, investment in people and development of their professional qualities, which form modern productive abilities and turn them into the main productive knowledge-based force in the conditions of decentralization of power and participation of citizens in local self-government.
The necessary cooperation of newly created communities with higher education institutions and the use of their potential for the formation, development of intellectual capital and further innovative development is proved. The mutually beneficial synergistic effect for their development is substantiated on the example of cooperation of the studied communities with the university.
Родина Штігліців в Одесі: сімейна історія в просторі українського мегаполіса
Authors: Bulanyi Mykola 
Published: April 2022

В статті проаналізовано внесок баронів Штігліців у розвиток Одеси, а також здійснено спробу імплементації родинної історії та місць пам’яті в просторовий контекст сучасного українського мегаполісу. Адже осягнення простору сучасних міст в умовах декомунізаційних процесів у черговий раз зумовлює переоцінку спадщини міст, особливо з потужним імперським минулим. У нагоді для цього стали як загальнонаукові методи аналізу, синтезу, так і спеціальні історичні методи компаративного аналізу та герменевтики джерельного матеріалу. При цьому було залучено різновидові джерела задля досягнення основної мети – пошуку місць пам’яті, пов’язаних з баронами Штігліцами, та виявлення основних можливих точок на мапі Одеси.
Окремо була охарактеризована теоретична база, що, крім іншого, дозволило виявити сучасні уявлення й ставлення до роду Штігліців у різних країнах Європи. Завдяки цьому можливо доповнення краєзнавчих збірок, розробка екскурсійних маршрутів, створення меморіальних табличок щодо внеску братів Штігліців у розвиток краю. Особливо враховуючи те, що Штігліци були одними з перших конвертованих євреїв Російської імперії станом на кінець XVIII ст. й саме Південь України відіграв значну роль у піднесенні роду. Адже німецькі придворні євреї саме тут прийняли лютеранство, отримали стартову базу, права іноземного купецтва, а згодом перемістили власні капітали до Петербургу, де одна з гілок роду й отримала від Миколи І баронський титул. Причому це був єдиний випадок надання баронства імператором протягом усього його правління. В ході дослідження було встановлено кілька важливих об’єктів та знакових для Штігліців місць, а також виявлено вулицю, яка носила ім’я барона Л. Штігліца. Окрім того вдалося простежити вплив родини Штігліців не лише на торгівельно-промислове піднесення Одеси, але й на фінансовий та культурний розвиток імперського міста.