bluuebunny/crossref_metadata_2025_split huggingface dataset:
Otherwise
Authors: Meek Laura A. , Morales Fontanilla Julia Alejandra 
Published: June 2022

AbstractIn this article we offer the term otherwise as a keyword for feminist vocabulary. We consider how the otherwise is simultaneously a concept, an analytics, a method, and an ethico‐onto‐political commitment to the insistence of the possible against the pull of the probable. The otherwise conjures latent possibilities and potentialities held within a situation or formation—which we might only glimpse obliquely, yet which holds or opens to liberatory transformation. While a standard genealogy of the term might trace its theoretical lineage, we aim to enact the otherwise we write by decentering this genealogy. Our essay is situated in conversation with feminist Black studies, science and technology studies, and decolonial studies, seeking to potentiate the transformative possibilities of bringing together these literatures. We explore the world‐making capacities of an otherwise anthropology through practices such as: attunement to the political in the mundane; speculative colaboring as a form of care; the fracturing of anthropological epistemologies; writing as a complex we; and not knowing. Finally, our collaborative essay is refracted through our respective experiences of social unrest and protests in Hong Kong and Colombia to enact an unruly and undisciplined genealogy of the otherwise, written from here, now.
Rhyacian‐Orosirian Khondalite Belt in the Borborema Province (NE Brazil): An active margin setting based on U–Pb zircon and monazite constraints
Authors: Muniz Robert Lima , dos Santos Ticiano José Saraiva , Dantas Elton L. , Fuck Reinhardt A. 
Published: June 2022

Khondalite belts are of special importance is delimiting old suture zones and in palaeocontinental reconstruction of Precambrian terrains. In the South‐American Platform, khondalitic rocks surround cratonic areas and Archean blocks reworked in the Neoproterozoic, an example of which being the Ceará Khondalite Belt (CKB). Located in the northern portion of the Borborema Province in NE Brazil, CKB is here described by means of its petrographic, structural, and LA‐SF‐ICP‐MS zircon and monazite U–Pb geochronological characteristics. CKB constitutes an E‐W to NE–SW striking belt comprising migmatitic spinel (hercynite)‐ and graphite‐bearing cordierite‐garnet‐sillimanite‐biotite gneisses, small granulitic boudins, garnet‐biotite quartzite, lenses of garnet amphibolite, calc‐silicate rock, gondite, and mylonitized leucogneiss. Relicts of Palaeoproterozoic island and continental arcs surrounding CKB are represented by tonalitic and dioritic gneiss, respectively. The contact between CKB and the Neoproterozoic Independência Unit is marked by a transpressional shear zone to the north, whereas the contact between CKB and Archean and Palaeoproterozoic rocks to the south is via a N‐verging thrust fault. The metamorphic peak is given by the parageneses: spinel (hercynite)‐quartz, spinel (hercynite)‐cordierite, and cordierite‐sillimanite‐garnet, possibly stable under UHT conditions. Crystallization ages of 2,086 ± 8 Ma and 2,063 ± 9 Ma were obtained by dating CKB migmatitic dioritic orthogneisses using the zircon U–Pb method. The CKB para‐derived rocks yielded detrital zircon U–Pb age peaks at 2,190, 2,130, and 2,060 Ma. Three metamorphic stages are identified in the Palaeoproterozoic via U–Pb dating of zircon rims and monazite at 2,094 ± 4 Ma, 2,055 ± 5 Ma, and 1,958 ± 3 Ma. A fourth metamorphic event with associated migmatization in shear zones took place in the Neoproterozoic between 595 ± 6 Ma and 573 ± 15 Ma, as indicated by dating zircon rims and monazite, respectively. Our study shows that the metamorphic events occurring in CKB in the Palaeoproterozoic share similarities with those that affected the khondalitic rocks bordering the São Francisco and the North China cratons, which suggests the existence of a continuous orogen during the Rhyacian‐Orosirian related to the Columbia Supercontinent amalgamation.
Pharyngeal tongue base augmentation for dysphagia therapy: A prospective case series in patients post head and neck cancer treatment
Authors: Schar Mistyka S. , Omari Taher I. , Woods Charmaine M. , Footner Lauren R. , Marshall Nicholas , Cock Charles , Thompson Alison , Nguyen Thi , Athanasiadis Theodore , Ooi Eng H. 
Published: June 2022

AbstractBackgroundDysphagia post head and neck cancer (HNC) multimodality treatment is attributed to reduced pharyngeal strength. We hypothesized that pharyngeal tongue base augmentation for dysphagia (PAD therapy) would increase pharyngeal pressures during swallowing thereby improving swallow symptoms.MethodsAdults with moderate–severe dysphagia post‐HNC treatment had PAD therapy using a temporary filler (hyaluronic acid [HA]), with follow‐up long‐lasting lipofilling. Swallowing preprocedure and postprocedure was assessed with the Sydney Swallow Questionnaire (SSQ), High‐Resolution Pharyngeal Manometry (HRPM), and Videofluoroscopic Swallowing Study (VFSS). Statistical comparison utilized paired tests.ResultsSix participants (all male; median age 64 years [IQR 56, 71]) underwent PAD therapy at a median of 47 [IQR 8, 95] months post‐treatment. SSQ scores reduced from baseline (mean 1069 [95%CI 703, 1434]) to post‐HA (mean 579 [76, 1081], p > 0.05), and post‐lipofilling (491 [95%CI 913, 789], p = 0.003, n = 4). Individual participants demonstrated reduced Swallow Risk Index, Bolus Presence Time, and increased Upper Esophageal Sphincter opening, but mesopharyngeal contractile pressures were unchanged. VFSS measures of aspiration, residue, and severity were unchanged.ConclusionsNovel PAD therapy is safe and improves dysphagia symptoms. Biomechanical swallowing changes are suggestive of more efficacious bolus propulsion with conservative filler volume, but this was unable to resolve residue or aspiration measures.
Use of local waste for biochar production: Influence of feedstock and pyrolysis temperature on chromium removal from aqueous solutions
Authors: Arán Daniela S. , Deza María , Monferrán Magdalena V. , Pignata M. Luisa , Harguinteguy Carlos A. 
Published: June 2022

Abstract
Sediment enrichment with biochar, a high-carbon material produced by the pyrolysis of biomass, is a promising remediation strategy for metal pollution. The metal immobilization capacity of biochar can be explained by its porous structure, surface functional groups, pH greater than 7, and cation exchange capacity. However, the effectiveness in reducing metal bioavailability depends on the physicochemical characteristics of the biochar, which are strongly associated with the process conditions and feedstock. The aims of this study were to analyze the effect of pyrolysis temperature on the properties of biochars derived from different locally available biomass materials, biochar potential to adsorb Cr, and biochar phytotoxicity in seed germination. Poultry litter (PL), maize straw, the macrophyte Juncus imbricatus, and phytoremediation wastes from the macrophyte previously exposed to Cr were pyrolyzed into biochar at 300 °C and 600 °C. The properties and capacity of biochar to remove Cr from the aqueous phase were determined. Finally, a germination assay was performed to evaluate biochar phytotoxicity. Biochar yield decreased with increasing pyrolysis temperature, whereas ash content and pH increased. Biochar C content and total surface area increased with temperature. Biochar Cr removal capacity improved under the highest temperature, reaching a maximum sorption value of 13.7 mg g−1 Cr at 300 °C in PL biochar and of 42.6 mg g−1 Cr at 600 °C in J. imbricatus biochar. Despite the comparatively high metal content in the biochar, the germination indices of all biochars produced at 600 °C were higher than 80%, suggesting no phytotoxicity. Considering the metal sorption capacity and the phytotoxicity, biochars produced from J. imbricatus, PL, and phytoremediation residues at 600 °C were suitable for use in the removal of Cr from water. Integr Environ Assess Manag 2023;19:717–725. © 2022 SETAC
Application of autonomous sensor technology to estimate selenium exposure and a site-specific selenium threshold in a Canadian boreal lake
Authors: Peixoto Mendes Maíra , Cupe-Flores Beatriz , Panigrahi Banamali , Liber Karsten 
Published: June 2022

Abstract
There is an increasing trend in the use of real-time sensor technology to remotely monitor aquatic ecosystems. Commercially available probes, however, are currently not able to measure aqueous selenium (Se) concentrations. Because of the well-described bioaccumulation potential and associated toxicity of Se in oviparous vertebrates, it is crucial to monitor Se concentrations at sites receiving continuous effluent Se input. This study aimed to estimate Se concentrations in a boreal lake (McClean Lake) downstream from a Saskatchewan uranium mill using real-time electrical conductivity (EC) data measured by autonomous sensors. Additionally, this study aimed to derive a site-specific total aqueous Se (TSe) threshold based on Se concentrations in periphyton and benthic macroinvertebrates sampled from the same lake. To characterize effluent distribution within the lake, eight Smart Water (Libelium) sensor units were programmed to report EC and temperature for five and seven consecutive weeks in 2018 and 2019, respectively. In parallel, periphyton and benthic macroinvertebrates were sampled with Hester-Dendy's artificial substrate samplers (n = 4) at the same sites and subsequently analyzed for Se concentrations. Electrical conductivity was measured with a handheld field meter for sensor data validation and adjusted to the median lake water temperature (13 °C) registered for the deployment periods. Results demonstrated good accuracy of sensor readings relative to handheld field meter readings and the successful use of real-time EC in estimating TSe exposure (r = 0.87; r2 = 0.84). Linear regression equations derived for Se in detritivores versus Se in periphyton and Se in periphyton versus sensor-estimated TSe were used to estimate a site-specific TSe threshold of 0.7 µg/L (±0.2). Moreover, mean Se concentrations in periphyton (16.7 ± 4.4 µg/g dry weight [d.w.]) and benthic detritivores (6.0 ± 0.4 µg/g d.w.) from one of the exposure sites helped identify an area with potential for high Se bioaccumulation and toxicity in aquatic organisms in McClean Lake. Integr Environ Assess Manag 2023;19:395–411. © 2022 SETAC
Forecasting equity risk premium: A new method based on wavelet de‐noising
Authors: Dai Zhifeng , Kang Jie , Yin Hua 
Published: June 2022

AbstractForecasting equity risk premium is notoriously difficult due to a mass of data noise in the raw series and the absence of clear tendency. Using the monthly S&P 500 excess returns from 1927:01 to 2018:12, we first de‐noise the in‐sample original returns series via wavelet method to capture the basic trend of equity risk premium, and then propose forecasting models to obtain one‐step forward out‐of‐sample predicted values based on the de‐noised returns. Our new models can provide substantially superior out‐of‐sample performance compared with other competing models and the historical average. Sizeable economic gains can be realized by a mean–variance investor if they allocate their asset through the new approach. Our findings are robust under different settings from both statistical and economic perspectives.
Protective effect of pterostilbene in a streptozotocin‐induced mouse model of Alzheimer's disease by targeting monoamine oxidase B
Authors: Li Qiushi , Li Xidong , Tian Buxian , Chen Long 
Published: June 2022

AbstractAlzheimer's disease (AD) is a neurodegenerative disease in elderly population. Pterostilbene (PTS) is a resveratrol analog with neuroprotective activity. However, the biological mechanisms of PTS in AD progression are largely uncertain. An animal model of AD was established using streptozotocin (STZ)‐treated C57BL/6J mice. Monoamine oxidase B (MAOB) expression was analyzed by bioinformatics analysis and detected by western blotting assay. The memory impairment was investigated by Morris water maze test. The levels of Tau hyperphosphorylation and death‐related proteins were detected by western blotting analysis. The levels of amyloid β (Aβ)1–42 accumulation, oxidative stress‐related markers (ROS, MDA, SOD, and GSH), and inflammation‐relative markers (TNF‐α, IL‐1β, IL‐6, and p‐NF‐κB) were measured by ELISA. MAOB expression was increased in hippocampus of AD mice, and it was decreased by PTS. PTS attenuated STZ‐induced body weight loss and memory impairment by regulating MAOB. PTS mitigated Aβ1–42 accumulation and Tau hyperphosphorylation by regulating MAOB in STZ‐treated mice. PTS attenuated neuronal death by decreasing cleaved caspase‐3 and Bax levels and increasing Bcl2 expression in hippocampus by regulating MAOB in STZ‐treated mice. PTS weakened STZ‐induced oxidative stress in hippocampus by decreasing ROS and MDA levels and increasing SOD and GSH levels by regulating MAOB. PTS protected against STZ‐induced neuroinflammation in hippocampus by inhibiting TNF‐α, IL‐1β, IL‐6, and p‐NF‐κB levels through regulating MAOB. In conclusion, PTS alleviates STZ‐induced memory impairment, Aβ1–42 accumulation, Tau hyperphosphorylation, neuronal death, oxidative stress, and inflammation by decreasing MAOB in AD mice, proving anti‐AD potential of PTS.
Monitoring of irrigated lesion formation with single fiber based multispectral system using machine learning
Authors: Park Soo Young , Singh‐Moon Rajinder P. , Yang Haiqiu , Hendon Christine P. 
Published: June 2022

AbstractIn radiofrequency ablation (RFA) treatment of cardiac arrhythmias, intraprocedural assessment of treatment efficacy relies on indirect measures of adequate tissue destruction. Direct sensing of diffuse reflectance spectral changes at the ablation site using optically integrated RFA catheters has been shown to enable accurate prediction of lesion dimensions, ex vivo. Challenges of optical guidance can be due to obtaining reliable measurements under various catheter‐tissue contact orientations. In this work, addressed this limitation by assessing the feasibility of monitoring lesion progression using single‐fiber reflectance spectroscopy (SFRS). A total of 110 endocardial lesions of various sizes were generated in freshly excised swine right ventricular tissue using a custom‐built, irrigated SFRS‐RFA catheter. Models were developed for assessing catheter‐tissue contact, the presence of nontransmural or transmural lesions and lesion depth percentage. These results support the use of SFRS‐based catheters for irrigated lesion assessment and motivate further exploration of using multi‐SFRS catheters for omnidirectionality.
Recent advancement in polymer/halloysite nanotube nanocomposites for biomedical applications
Authors: Mohamed Haneef Intan Najwa Humaira , Mohd Shaffiar Norhashimah , Buys Yose Fachmi , Syed Shaharuddin Sharifah Imihezri , Abdul Hamid Abdul Malek , Widiyati Khusnun 
Published: June 2022

AbstractHalloysite nanotubes (HNTs) have recently been the subject of extensive research as a reinforcing filler. HNT is a natural nanoclay, non‐toxic and biocompatible, hence, applicable in biomedical fields. This review focuses on the mechanical, thermal, and functional properties of polymer nanocomposites with HNT as a reinforcing agent from an experimental and theoretical perspective. In addition, this review also highlights the recent applications of polymer/HNT nanocomposites in the biomedical fields.
Drug Disposition in Subjects With Obesity: The Research Work of Darrell R. Abernethy
Authors: Greenblatt David J. , Bruno Christopher D. , Harmatz Jerold S. , Zhang Qingchen , Chow Christina R. 
Published: June 2022

AbstractIn 1979, the late Dr. Darrell R. Abernethy and colleagues began a series of clinical studies aimed at understanding the pertinent determinants of drug distribution, elimination, and clearance in obesity, and how those variables are interconnected. The studies confirmed that volume of distribution (Vd) and clearance are the principal independent biological variables, which conjointly determine elimination of half‐life as a dependent variable. For drugs distributed by passive diffusion, their pharmacokinetic Vd — after correcting for plasma protein binding — was increased in obesity, depending in part on the physicochemical lipophilicity of the individual drugs, and the quantitative extent of obesity in overweight individuals. Across all studies, the ratio of mean clearance in obese divided by control groups had an overall median value of 1.21 (range, 0.75‐3.11), indicating a small and variable effect of obesity on clearance, without clear directionality. Since drug clearance was not clearly related to lipophilicity or degree of obesity, the prolonged half‐life of lipophilic drugs in patients with obesity was largely explained by the increased Vd. Dr. Abernethy further identified delayed attainment of steady state after initiation of multiple‐dose treatment, and delayed washout after termination of dosage, as potential clinical consequences of the extended half‐life in people with obesity. These consequences for specific drugs have been recently emphasized in contemporary studies of chronic dosage in subjects with obesity. Without data identifying an obesity‐related change in clearance for a specific drug, maintenance doses (in milligrams) should be based on ideal weight rather than adjusted upward on the basis of total weight.
Intertwin membrane cord insertion in dichorionic twin pregnancy: The description and comparison with other umbilical cord insertion types
Authors: Can Sultan , Has Recep , Turkyilmaz Gurcan , Aktoz Fatih , Yuksel Atil 
Published: June 2022

AbstractPurposeMultiple pregnancy is associated with high perinatal mortality and morbidity. Abnormal cord insertions more common in twin pregnancies compared to singleton pregnancies and velamentous cord insertion is related with poor pregnancy outcomes. There is no definition of velamentous cord insertion into the intertwine membrane between two fetuses in the literature.MethodsIn our single‐center cross‐sectional study, monochorionic‐diamniotic and dichorionic‐diamniotic twins who were admitted to our clinic between 18 + 0 and 23 + 6 weeks of pregnancy were enrolled in this study. We evaluated fetal, placental, and umbilical cord abnormalities in addition to fetal growth restrictions and weight discordance by ultrasonography.ResultsAlthough abnormal cord insertion frequency was significantly higher in monochorionic twins (p = 0.003), intertwin membrane cord insertion could only occur in dichorionic twins. In cases with cord insertion anomaly; FGR and weight discordance was observed more frequently (p < 0.001 and p = 0.003, respectively). Weight discordance, the presence of abnormal cord insertion and abnormal UAD were found as statistically significant predictors of FGR (p < 0.001, p = 0.021, and p < 0.001, respectively).ConclusionIntertwin membrane insertion is a novel umbilical cord insertion abnormality. The presence of abnormal umbilical cord insertion is a risk factor for poor pregnancy outcomes in twin pregnancies.
The prolyl hydroxylase inhibitor GSK1120360A reduces early brain injury, but protection is not maintained in a neonatal rat model of hypoxic ischaemic encephalopathy
Authors: Jones Nicole M. , Nathanson Anton D. , Chell Simon , DeAngelis Elena , Whelan Greg , Willé David , Cheng Katharine 
Published: June 2022

AbstractHypoxic–ischemic encephalopathy (HIE) in newborns is associated with high morbidity and mortality, with many babies suffering long‐term neurological deficits. Currently, treatment options are limited to therapeutic hypothermia, which is not appropriate for use in all babies. Previous studies have shown protective effects of increasing the transcription factor—hypoxia‐inducible factor‐1 (HIF‐1) in animal models, by using mild hypoxia or compounds that act as prolyl hydroxylase inhibitors (PHIs). Here, we aimed to examine the neuroprotective actions of an orally active, small molecule PHI, GSK1120360A in a neonatal rat model of hypoxia‐ischemia (HI) compared to another PHI, desferrioxamine (DFX). Sprague–Dawley rats underwent HI surgery on postnatal day 7 (P7), where unilateral carotid artery occlusion was performed followed by hypoxia (8% oxygen, 3 h). Initial testing showed that GSK1120360A and erythropoietin levels were detectable in plasma at 6 h following oral exposure to GSK1120360A. For the short‐term neuroprotection study, pups were assigned to receive either saline (s.c), desferrioxamine (DFX—200 mg/kg, s.c), methylcellulose (1%, oral) or GSK1120360A (30 mg/kg, oral) immediately after HI. Histological analysis showed that GSK1120360A in this setting reduced brain injury size 7 days after HI, compared to the methylcellulose vehicle control group. DFX had no significant effect on injury size compared to saline group at the same 7 day timepoint. In the long‐term neuroprotection study, pups were randomly assigned to be administered methylcellulose (1%, oral) or GSK1120360A (30 mg/kg, oral) immediately after HI. On P42, rats underwent behavioural testing using the forelimb grip strength, grid walking and novel object recognition tasks, and brains were collected for histological analysis. Long‐term behavioural deficits were observed in grid walking, grip strength and novel object recognition tests after HI which were not improved in the GSK1120360A treatment group compared to the methylcellulose group. Similarly, there was no improvement in injury size on P42 in the GSK1120360A study group compared to the methylcellulose group. Here, we have shown that GSK1120360A can reduce brain injury at 7 days but that this neuroprotective benefit is not maintained when examined at 5 weeks after HI.