bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe mental illness and quality of diabetes care: a retrospective national linked cohort study.
Authors: Scheuer Stine , Fleetwood Kelly , Licence Kirsty , Mercer Stewart , Smith Daniel , Wild Sarah , Jackson Caroline 
Published: September 2022

ObjectiveTo use a Scottish national linked diabetes care dataset to determine whether annual monitoring of clinical guideline-recommended diabetes care indicators differ by severe mental illness (SMI) status among people with type 2 diabetes (T2D) during the first year following diabetes diagnosis and thereafter.
ApproachWe examined receipt of 9 diabetes care indicators (HbA1c; cholesterol; urinary albumin; serum creatinine; blood pressure; retinopathy screening; foot examination; body mass index; and smoking status) in people with T2D diagnosed 2009-2018, comparing people with a prior hospital record of schizophrenia, bipolar disorder and depression versus no hospital record for any mental illness. We analysed receipt of care in the first year using logistic regression and for the entire follow-up period (until death or 31 December 2018) using generalized linear mixed effects models, adjusting for calendar year, sociodemographic and lifestyle factors and comorbidities (and in the latter, diabetes duration).
ResultsWe included 119,508 people with T2D (mean age 59.7 [±13.2 SD]), of which 1701 (1%), 768 (0.5%) and 5211 (3%) had schizophrenia, bipolar disorder and depression, respectively. During the first year, compared to people without mental illness those with each SMI were more likely to receive cholesterol and serum creatinine measurement and, for schizophrenia only, HbA1c measurement, after adjustment for confounding factors. People with depression had higher odds of receiving a smoking review, but lower odds of receiving urinary albumin measurement. Receipt of all other indicators were similar across comparison groups. In the longitudinal analyses, people with schizophrenia had persistently higher odds of receiving HbA1c and people with a SMI had lower odds of receiving retinopathy screening.
ConclusionReceipt of care delivered in the primary care setting was generally similar in people with versus without SMI in the short and long term. However, people with SMI were less likely to receive retinopathy screening, highlighting a need for better monitoring of care indicators delivered outside primary care settings.
Health service use of infants involved in family justice care and supervision proceedings in Wales: a longitudinal national data linkage study.
Authors: Farr Ian , Jones Carys , Cowley Laura , Alrouh Bachar , Cusworth Linda , Akbari Ashley , Doebler Stefanie , Broadhurst Karen , Odd David , Griffiths Lucy 
Published: September 2022

ObjectiveWhen an infant is identified as having suffered or is at risk of suffering significant harm from parents or caregivers, section 31 care and supervision proceedings (s.31, Children Act 1989) may be issued. We examined the healthcare use of infants under one year old subject to these proceedings in Wales.
ApproachA retrospective e-cohort study utilising data held in the Secure Anonymised Information Linkage (SAIL) Databank. General Practice records, emergency department attendances, and hospital admissions (non-elective and elective) were linked with family justice (Cafcass Cymru) data between 2011–2020 for all s.31 proceedings (n = 920). By comparing to the infant population not undergoing family law proceedings (n = 18179), regression models examined the incidence and rate of healthcare events between birth and the court proceeding application date. Wider determinants of health were sequentially added (infant perinatal factors, maternal mental health, sex, area-level deprivation). Reasons for healthcare events were also investigated.
ResultsThese models showed that infants who were subject to s.31 care and supervision proceedings were more likely to have required healthcare prior to proceedings than the comparison group. A similar pattern was shown for the rate of healthcare events. Even when wider determinants of health were included in the models, this difference was especially pronounced for incidence and event rate ratios for emergency department attendances, [incidence RR = 1.73, CI = 1.52–1.96; event RR = 2.08, CI = 1.82–2.38] and non-elective inpatient admissions [incidence RR = 2.91, CI = 2.57–3.28; event RR = 3.84, CI = 3.31–4.45]. Infants in s.31 proceedings were more likely to require healthcare for injury and poisoning, and other external causes.
ConclusionThis is the first population-wide evidence on the health of infants subject to s.31 care and supervision proceedings in Wales. These findings highlight the increased healthcare utilisation for this population. The study helps to build a better understanding of the needs and vulnerabilities of infants in the family justice system.
Analysing linked 2021 Census and Admin data to inform population transformation statistics.
Authors: Pereira Elizabeth 
Published: September 2022

ObjectivesTo analyse the linked dataset between England and Wales 2021 Census/Census Coverage Survey and the Demographic Index (DI), would provide insights on quality and coverage, enabling improvements of using admin data to form population/ household estimates for future linkages and to evidence additional admin sources needed to capture the population.
ApproachThe DI is a composite dataset made up of several linked admin sources. Therefore, the linked output is complex, made up of clusters where individual sources within the clusters have been linked to the Census using the different available information across sources. To carry out the analysis, a flagging strategy has been designed to enable analysts to form cuts of the linked dataset that are specific to their research needs. High level research questions have been designed to provide fast paced analysis to inform the National Statistician’s 2023 recommendation on the need for a future Census.
ResultsThe results will inform the National Statistician’s 2023 recommendation, but also the future delivery of transformed population and migrations statistics . This includes:

Providing insight into how to improve the current linkage methodology of the DI
How we use the DI to construct Statistical Population Datasets (which use inclusion rules to establish the usual resident population)
Identifying the extent of over and under coverage in the Statistical Population Datasets, allowing development of an appropriate estimation strategy to more accurately estimate the population

The results will also inform how we utilise linked composite data sources in the future, as we can share the lessons learnt in how we planned to use the data, including our flagging strategy verses the reality faced when undertaking the analysis.
ConclusionThis analysis will inform approaches to using linked composite data in the future but also provide a wealth of knowledge including: informing linkage methods, defining the population estimation challenge and providing insights into how we deliver admin based population estimates.
3D Modeling System of Indoor Environment Art Landscape Design under Statistical Equation
Authors: Hao Huinan , Al-Juboori Udai Ali 
Published: September 2022

Abstract
This paper establishes a three-dimensional virtual landscape model based on statistical equations. This paper completes the analysis of interior design requirements by analyzing the structure of the interior design platform and the indoor positioning algorithm from the three-dimensional virtual perspective. We realize the 3D reconstruction of indoor landscape through the 3D visual image reconstruction module and VRLM browser module. The experimental results show that the designed 3D virtual landscape is more realistic. Its artistic effect is better.
Integrated Gamification Model in a Constructivist Learning Environment for the Promotion of Creative Skills
Authors: Parra Xochitl Clemente , García Fausto Abraham Jacques 
Published: September 2022

Abstract
The Knowledge Society has highlighted the importance of creativity as a goal competence, which should be fostered in higher education institutions; therefore, it is necessary to integrate innovative educational experiences oriented to the development of creativity complementing the professional training of students. Recent research from psychology and pedagogy reports advances associated with the nature, evaluation, composition, and conditions for teaching creativity that have resulted in successful applications in only one facet of the creative process. In this research, we propose an integrated model for making educational interventions through online courses. This model combines contributions to the teaching of creativity from pedagogy in relation to the pedagogical model, instructional design, and conditions of the teaching-learning process required for the promotion of creativity. It also includes the contributions of psychology in relation to the cognitive processes and skills associated with creativity, the techniques and activities for the development of creative skills, as well as the principles associated with intrinsic motivation based on the theory of self-determination through its application in the learning technique called gamification. The advantage of this integrated model is that it incorporates and fosters multiple components of creativity simultaneously, with the objective of generating creative results of greater breadth and quality.
Pseudomonas aeruginosanosocomial meningitis following spinal anesthesia – still a significant treatment dilemma
Authors: Kolovani Entela , Ramosaço Ergys , Xhumari Artur , Vyshka Gentian , Ranxha Eris 
Published: September 2022

Background:Infections of central nervous system after spinal anesthesia nowadays are a rarity; however, their presence might be of concern.Case Description:We report the case of lateral ventricular empyema treated unsuccessfully with parenteral antibiotic therapy, with the clinical signs of a persisting meningitis. After several lumbar taps suggesting an infection,Pseudomonas aeruginosawas isolated and a brain magnetic resonance imaging find out the collection in the left horn of the lateral ventricle. An intrathecal/intraventricular antibiotic therapy with colistin proved highly effective combined with an extra ventricular drainage to deal with the hydrocephaly.Conclusion:Clinicians should take into account even uncommon infectious agents while facing the picture of a meningitis otherwise nonresponsive to empiric or standard therapy.
Age-specific associations between underlying health conditions and hospitalisation, death and in-hospital death among confirmed COVID-19 cases: a multi-country study based on surveillance data, June to December 2020
Authors: Funk Tjede , Innocenti Francesco , Gomes Dias Joana , Nerlander Lina , Melillo Tanya , Gauci Charmaine , Melillo Jackie M , Lenz Patrik , Sebestova Helena , Slezak Pavel , Vlckova Iva , Berild Jacob Dag , Mauroy Camilla , Seppälä Elina , Tønnessen Ragnhild , Vergison Anne , Mossong Joël , Masi Silvana , Huiart Laetitia , Cullen Gillian , Murphy Niamh , O’Connor Lois , O’Donnell Joan , Mook Piers , Pebody Richard G , Bundle Nick 
Published: September 2022

Background
Underlying conditions are risk factors for severe COVID-19 outcomes but evidence is limited about how risks differ with age.

Aim
We sought to estimate age-specific associations between underlying conditions and hospitalisation, death and in-hospital death among COVID-19 cases.

Methods
We analysed case-based COVID-19 data submitted to The European Surveillance System between 2 June and 13 December 2020 by nine European countries. Eleven underlying conditions among cases with only one condition and the number of underlying conditions among multimorbid cases were used as exposures. Adjusted odds ratios (aOR) were estimated using 39 different age-adjusted and age-interaction multivariable logistic regression models, with marginal means from the latter used to estimate probabilities of severe outcome for each condition–age group combination.

Results
Cancer, cardiac disorder, diabetes, immunodeficiency, kidney, liver and lung disease, neurological disorders and obesity were associated with elevated risk (aOR: 1.5–5.6) of hospitalisation and death, after controlling for age, sex, reporting period and country. As age increased, age-specific aOR were lower and predicted probabilities higher. However, for some conditions, predicted probabilities were at least as high in younger individuals with the condition as in older cases without it. In multimorbid patients, the aOR for severe disease increased with number of conditions for all outcomes and in all age groups.

Conclusion
While supporting age-based vaccine roll-out, our findings could inform a more nuanced, age- and condition-specific approach to vaccine prioritisation. This is relevant as countries consider vaccination of younger people, boosters and dosing intervals in response to vaccine escape variants.
Cranioplasty in the deployed environment: experience for host-country nationals
Authors: Porensky Paul N. , Maloney Patrick R. , Kim Jeeho D. , Dye Justin A. , Liacouras Peter C. 
Published: September 2022

OBJECTIVE
Decompressive craniectomy (DC) is the definitive neurosurgical treatment for managing refractory malignant cerebral edema and intracranial hypertension due to combat-related severe traumatic brain injury (TBI). To date, the long-term outcomes and sequelae of this procedure on host-country national (HCN) populations during Operation Iraqi Freedom (Iraq, 2003–2011), Operation Enduring Freedom (Afghanistan, 2001–2014), and Operation Freedom’s Sentinel (Afghanistan, 2015–2021) have not been described, specifically the process and results of delayed custom synthetic cranioplasty. The Joint Trauma System’s Clinical Practice Guidelines (JTS-CPG) for severe head injury counsels surgeons to discard the cranial osseous explant when treating coalition service members. Ongoing political and healthcare system instabilities often preclude opportunities for delayed cranioplasty by host-country assets. Various surgical options (such as hinge craniectomy) are inadequate in the setting of complicated cranial comminution from blast or missile injuries, severe cerebral edema, grossly contaminated wounds, complex polytrauma, and tissue devitalization. Delayed cranioplasty with a custom synthetic implant is a viable but logistically challenging alternative. In this retrospective review, the authors present the first patient series describing delayed custom synthetic cranioplasty in an HCN population performed during active military conflict.

METHODS
Patients were identified through the Joint Trauma System/Theater Medical Data Store, and subgroup analyses were performed to include mechanisms of injury, surgical complications, and clinical outcomes.

RESULTS
Twenty-five patients underwent DC between 2012 and 2020 to treat penetrating, blast, and high-energy closed head injuries per JTS-CPG criteria. The average time from injury to surgery was 1.4 days, although 6 patients received delayed care (3–6 days) due to protracted evacuation from local hospitals. Delayed care correlated with an increased rate of intracranial abscess and empyema. The average time to cranioplasty was 134 days due to a lack of robust mechanisms for patient follow-up, tracking, and access to NATO hospitals. HCN patients who recovered from DC demonstrated overall benefit from custom synthetic cranioplasty, although formal statistical analysis was impeded by a lack of long-term follow-up.

CONCLUSIONS
This review demonstrates that cranioplasty with a custom synthetic implant is a safe and feasible treatment for vulnerable HCN patients who survive their index DC surgery. This unique paradigm of care highlights the capabilities of deployed neurosurgical healthcare teams working in partnership with the prosthetics laboratory at Walter Reed National Military Medical Center.
Impact of a cell cycle and an extracellular matrix remodeling transcriptional signature on tumor progression and correlation with EZH2 expression in meningioma
Authors: Pereira Benedito Jamilson Araújo , Marcondes Lerario Antonio , Sola Paula Rodrigues , Laurentino Talita de Sousa , Mohan Dipika R. , de Almeida Antonio Nogueira , Pires de Aguiar Paulo Henrique , da Silva Paiva Wellingson , Wakamatsu Alda , Teixeira Manoel Jacobsen , Oba-Shinjo Sueli Mieko , Marie Suely Kazue Nagahashi 
Published: September 2022

OBJECTIVE
The authors searched for genetic and transcriptional signatures associated with tumor progression and recurrence in their cohort of patients with meningiomas, combining the analysis of targeted exome, NF2-LOH, transcriptome, and protein expressions.

METHODS
The authors included 91 patients who underwent resection of intracranial meningioma at their institution between June 2000 and November 2007. The search of somatic mutations was performed by Next Generation Sequencing through a customized panel and multiplex ligation-dependent probe amplification for NF2 loss of heterozygosity. The transcriptomic profile was analyzed by QuantSeq 3′ mRNA-Seq. The differentially expressed genes of interest were validated at the protein level analysis by immunohistochemistry.

RESULTS
The transcriptomic analysis identified an upregulated set of genes related to metabolism and cell cycle and downregulated genes related to immune response and extracellular matrix remodeling in grade 2 (atypical) meningiomas, with a significant difference in recurrent compared with nonrecurrent cases. EZH2 nuclear positivity associated with grade 2, particularly with recurrent tumors and EZH2 gene expression level, correlated positively with the expression of genes related to cell cycle and negatively to genes related to immune response and regulation of cell motility.

CONCLUSIONS
The authors identified modules of dysregulated genes in grade 2 meningiomas related to the activation of oxidative metabolism, cell division, cell motility due to extracellular remodeling, and immune evasion that were predictive of survival and exhibited significant correlations with EZH2 expression.
Neurotrauma: a burgeoning, yet understudied disease of rural areas in developing countries
Authors: Oyemolade Toyin A. , Adeleye Amos O. , Ehinola Busayo A. , Olusola Ayodele J. , Ekanem Inwonoabasi N. , Adesola Damilola J. 
Published: September 2022

OBJECTIVE
There is a paucity of data-driven reports on neurotrauma from the rural areas of developing countries, despite a disproportionally higher and burgeoning disease burden from those areas. This study aims to define the burden of neurotrauma in a new rural neurosurgical practice of a developing sub-Saharan country in Africa (Nigeria).

METHODS
The authors conducted a prospective observational study of all neurotrauma patients managed at their center over a 36-month period beginning in August 2018.

RESULTS
There were 1067 patients, 816 (76.5%) of them male, accounting for 79% of all the neurosurgical patients seen at the authors’ center during the study period. The peak incidence of neurotrauma was in the 20- to 29-year age group. The median trauma duration was 9 hours before presentation. The neurotrauma involved only head injury (HI) in 78% of the patients and only the spine in 4%. HIs were predominantly mild in severity (79%). Spinal cord injuries were largely incomplete (86%) and cervical in location (72%). Road traffic accidents caused approximately 79% (845/1067) of this neurotrauma burden, mostly from motorcycle crashes (69%, 581/845). Fifty-three patients (5%) were managed surgically. The median time from trauma to surgery for the operated patients was 82 hours. Treatment outcome was good in 81.2% of the patients.

CONCLUSIONS
Neurotrauma, mostly caused by motorcycle crashes and other road accidents, accounts for the bulk of the neurosurgical workload in this rural neurosurgical center. Although late presentation and delayed surgical interventions were prominent features of this level of care, the in-hospital outcome was fortuitously good in the majority of patients.
ANALISIS TINDAK TUTUR ILOKUSI PADA DIALOG FILM ANIMASI NUSSA EPISODE NUSSA: BELAJAR JUALAN
Authors: Putri Nurul Kamila Putri , Sinta Rosalina  
Published: September 2022

Tindak tutur ilokusi merupakan salah satu bagian dari jenis tindak tutur. Tindak tutur ilokusi berfungsi untuk mengungkapkan suatu hal yang hendak dicapai dengan cara mengkomunikasikan maksud/keinginan kepada lawan tutur untuk mencapai sesuatu. Tuturan tersebut dapat mempengaruhi sehingga lawan tutur melakukan sesuatu atau mengubah keadaan. Tujuan yang hendak dicapai dalam penelitian ini, yaitu untuk mengetahui (1) bentuk-bentuk tindak tutur ilokusi dalam dialog film serial animasi “Nussa episode Nussa” Belajar Jualan”. Penelitian ini menggunakan jenis pendekatan deskriptif kualitatif dengan sumber data berupa dialog tuturan para tokoh film serial animasi “Nussa episode Nussa: Belajar Jualan”. Dalam setiap adegan terdapat kegiatan komunikasi antara karakter satu dengan karakter lainnya. Tuturan-tuturan yang terdapat pada setiap dialog didominasi oleh ajaran pendidikan islam. Maka, dalam setiap dialog yang dituturkan akan mengalami peristiwa tindak tutur pada setiap karakternya. Teknik pengumpulan data yang digunakan pada penelitian ini, yaitu simak-catat dengan instrumen penelitian yakni peneliti sendiri. Penelitian ini menggunakan metode deskriptif kualitatif untuk menjabarkan hasil analisis data yang telah dilaksanakan. Berdasarkan hasil analisis data yang telah dilakukan pada dialog film serial animasi Nussa : Belajar Jualan terdapat tiga bentuk tindak tutur ilokusi meliputi, tindak tutur asertif yaitu, tuturan mengeluh dan menyarankan, tindak tutur direktif yakni tuturan permintaan, ajakan, nasihat dan larangan, terakhir yaitu ekspresif yakni tuturan ucapan terima kasih.
EKRANISASI NOVEL LAYANGAN PUTUS KARYA MOMY ASF KE DALAM FILM LAYANGAN PUTUS SUTRADARA BENNI SETIAWAN
Authors: Saepputra  , Ade Khusnul Mawadah  , Firman Hadiansyah  
Published: September 2022

Ekranisasi merupakan pelayar putihan atau pemindahan sebuah karya sastra novel ke dalam sebuah film. dalam sebuah ekranisasi akan ada beberapa perubahan. Tujuan penelitian ini akan membahas tentang penciutan, penambhan dan perubhan variasi. Maka dari itu peneliti melakukan penelitian ekranisasi dengan metode penelitian kualitatif deskriptif dengan cara membaca novel yang di teliti dengan kselurahn dan mencatat hal – apa saja yang di teliti. Selanjutnya peneliti juga menonton kembali film yang di angkat dari novel terseut dengan memahami dan mencatat bagian – bagian yang di anggapa penting. Hasil dari penelitian ini adalah adanya perubahan – perubahan dalam proses ekranisasi di temukan adanya pencitan dua latar yang ada dalam film, adanya penciutan narator dan pencitan tokoh dan penokohan. Dalam perubahan penambahan juga di temukan tambahan latar, dimana dalam novel tidak di ceritakan saat kinan sykuran 7 bulan anak keduanya, namun dalam film di tanyang adengan tersebut. Penambahan narator yang ada pada akhir film. sedangankan penambahan berupa tokoh juga terjadi dalam film seperti lola, andre dan nita. Perubahan variasi terjadi pada latar dimana kinan menjemput anaknya, perubahan variasi pada narotor tidak ditemukan, sedangkan pada tokoh dan penokohan kinan sebagai dokter hewan dalam novel namun dalam film kinan seorang dokter umum. Kesimpulan dari penelitian ini dalah perubahan yang terjadi pada proses ekranisasi ini akan terjadi, karena stradara melakukan penciutan, panambahan dan perubahan variasi hanya untuk memberikan klimaks terhadap penonton dan jalan cerita yang lebih menarik.