bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward digital validation for rapid product development based on digital twin: a framework
Authors: Huang Sihan , Wang Guoxin , Lei Dong , Yan Yan 
Published: January 2022

AbstractProduct development should cover product design, validation, and manufacturing. In traditional product development, physical validation based on physical trial manufacturing is the key step to confirm the design scheme before physical manufacturing. However, physical validation is costly and inefficient, which could be the main obstacle to achieving rapid product development. The emergence of digital twin provides an opportunity to accelerate product development by eliminating physical validation toward digital validation in the smart manufacturing era. Therefore, a framework of rapid product development based on digital twin is proposed in this paper. During product development, the new product is designed according to the new requirements in the virtual space, in which the existing digital twins of products can be referenced. Then, an ultrahigh-fidelity virtual manufacturing system is constructed for digital trial manufacturing based on the digital twin of the manufacturing system and the design scheme of the new product. An ultrahigh-fidelity digital prototype can be obtained from digital trial manufacturing for digital validation. The new product validation is executed on the digital prototype to test its performance. The digital validation results can be used to improve the design scheme of the new product and boost the corresponding manufacturing processes. In addition, the core characteristics and key technologies of rapid product development based on digital twin are discussed. Finally, a case study is presented to implement the proposed framework and to show the effectiveness of accelerating product development.
Can process accountability mitigate myopic biases? An experimental analysis
Authors: Ličen Mina , Slapničar Sergeja 
Published: January 2022

AbstractThis paper examines the impact of process accountability on two biases causing myopic or short-sighted decision making. These biases are strong preferences for immediate and certain outcomes known as delay and risk aversion. We hypothesize that accountability alone is insufficient to undo the biases, but if coupled with a cue on subjective discount rates, it will attenuate biases. To analyze our research question, we used a within- and between-subjects experimental design (two accountability conditions compared with a non-accountability condition and with each other) with delay and probability discounting choice tasks involving 118 students of accounting, finance and management in an online experiment. In line with our hypotheses, we find that process accountability successfully reduces excessive delay and risk aversion only if it provides a cue about the subjective discount rate. We discuss the implications of our findings for management control.
Integrating Ecosystem Services Into Water Resource Management: An Indicator-Based Approach
Authors: Shaad Kashif , Souter Nicholas J. , Vollmer Derek , Regan Helen M. , Bezerra Maíra Ometto 
Published: January 2022

AbstractNatural ecosystems are fundamental to local water cycles and the water ecosystem services that humans enjoy, such as water provision, outdoor recreation, and flood protection. However, integrating ecosystem services into water resources management requires that they be acknowledged, quantified, and communicated to decision-makers. We present an indicator framework that incorporates the supply of, and demand for, water ecosystem services. This provides an initial diagnostic for water resource managers and a mechanism for evaluating tradeoffs through future scenarios. Building on a risk assessment framework, we present a three-tiered indicator for measuring where demand exceeds the supply of services, addressing the scope (spatial extent), frequency, and amplitude for which objectives (service delivery) are not met. The Ecosystem Service Indicator is measured on a 0–100 scale, which encompasses none to total service delivery. We demonstrate the framework and its applicability to a variety of services and data sources (e.g., monitoring stations, statistical yearbooks, modeled datasets) from case studies in China and Southeast Asia. We evaluate the sensitivity of the indicator scores to varying levels data and three methods of calculation using a simulated test dataset. Our indicator framework is conceptually simple, robust, and flexible enough to offer a starting point for decision-makers and to accommodate the evolution and expansion of tools, models and data sources used to measure and evaluate the value of water ecosystem services.
Single-Centre Retrospective Study Using Propensity Score Matching Comparing Left Versus Right Internal Jugular Vein Access for Transjugular Intrahepatic Portosystemic Shunt (TIPS) Creation
Authors: Qiu Zhenkang , Zhu Wenliang , Yan Huzheng , Wang Guobao , Zuo Mengxuan , Qi Han , Wang Guisong , Jiang Weiwei , Xue Jingbing , Zhang Fujun , Gao Fei 
Published: January 2022

Abstract
Purpose
To compare the safety and efficacy of left versus right internal jugular vein access for portal vein puncture during transjugular intrahepatic portosystemic shunt (TIPS) creation in patients with a small liver and short vertical puncture distance.

Materials and Methods
The vertical distance from the hepatic vein orifice to the puncture point of the portal vein was measured by CT and DSA. A distance ≤ 30 mm is defined as a short vertical puncture distance. After 1:1 propensity score matching (PSM), 29 patients of left internal jugular vein-TIPS (LIJ-TIPS) and 29 patients of right internal jugular vein-TIPS (RIJ-TIPS) were included. The number of needle punctures, fluoroscopy time, and radiation dose during the puncture process were statistically analyzed.

Results
There was no significant difference in the average vertical puncture distances on CT or DSA between LIJ-TIPS and RIJ-TIPS (19.10 ± 0.60 mm vs. 19.30 ± 0.60 mm, P = 0.840; 22.02 ± 0.69 mm vs. 22.23 ± 0.64 mm, P = 0.822, respectively). The average number of needle punctures, fluoroscopy time, and radiation dose in LIJ-TIPS were significantly lower than those in RIJ-TIPS (2.07 ± 0.20 vs. 4.10 ± 0.24, P < 0.001; 78.45 ± 12.80 s vs. 201.16 ± 23.71 s, P < 0.001; 31.55 ± 7.04 mGy vs. 136.69 ± 16.38 mGy, P < 0.001, respectively). Within three punctures, the technical success rate in LIJ-TIPS was significantly higher than that in RIJ-TIPS (86.2 vs. 27.6%, P < 0.001). The incidence of hemoperitoneum in LIJ-TIPS was significantly lower than that in RIJ-TIPS (0% vs. 13.8%, P = 0.038).

Conclusion
The left internal jugular vein could be used as primary access for TIPS creation in patients with a small liver and short vertical puncture distance.
Diagnostic effect of artificial intelligence solution for referable thoracic abnormalities on chest radiography: a multicenter respiratory outpatient diagnostic cohort study
Authors: Jin Kwang Nam , Kim Eun Young , Kim Young Jae , Lee Gi Pyo , Kim Hyungjin , Oh Sohee , Kim Yong Suk , Han Ju Hyuck , Cho Young Jun 
Published: January 2022

Abstract
Objectives
We aim
ed to evaluate a commercial artificial intelligence (AI) solution on a multicenter cohort of chest radiographs and to compare physicians' ability to detect and localize referable thoracic abnormalities with and without AI assistance.

Methods
In this retrospective diagnostic cohort study, we investigated 6,006 consecutive patients who underwent both chest radiography and CT. We evaluated a commercially available AI solution intended to facilitate the detection of three chest abnormalities (nodule/masses, consolidation, and pneumothorax) against a reference standard to measure its diagnostic performance. Moreover, twelve physicians, including thoracic radiologists, board-certified radiologists, radiology residents, and pulmonologists, assessed a dataset of 230 randomly sampled chest radiographic images. The images were reviewed twice per physician, with and without AI, with a 4-week washout period. We measured the impact of AI assistance on observer's AUC, sensitivity, specificity, and the area under the alternative free-response ROC (AUAFROC).

Results
In the entire set (n = 6,006), the AI solution showed average sensitivity, specificity, and AUC of 0.885, 0.723, and 0.867, respectively. In the test dataset (n = 230), the average AUC and AUAFROC across observers significantly increased with AI assistance (from 0.861 to 0.886; p = 0.003 and from 0.797 to 0.822; p = 0.003, respectively).

Conclusions
The diagnostic performance of the AI solution was found to be acceptable for the images from respiratory outpatient clinics. The diagnostic performance of physicians marginally improved with the use of AI solutions. Further evaluation of AI assistance for chest radiographs using a prospective design is required to prove the efficacy of AI assistance.

Key Points
• AI assistance for chest radiographs marginally improved physicians’ performance in detecting and localizing referable thoracic abnormalities on chest radiographs.
• The detection or localization of referable thoracic abnormalities by pulmonologists and radiology residents improved with the use of AI assistance.
Can we increase efficiency of CT lung cancer screening by combining with CVD and COPD screening? Results of an early economic evaluation
Authors: Behr Carina M. , Koffijberg Hendrik , Degeling Koen , Vliegenthart Rozemarijn , IJzerman Maarten J. 
Published: January 2022

Abstract
Objectives
Estimating the maximum acceptable cost (MAC) per screened individual for low-dose computed tomography (LDCT) lung cancer (LC) screening, and determining the effect of additionally screening for chronic obstructive pulmonary disease (COPD), cardiovascular disease (CVD), or both on the MAC.

Methods
A model-based early health technology assessment (HTA) was conducted to estimate whether a new intervention could be cost-effective by calculating the MAC at a willingness-to-pay (WTP) of €20k/quality-adjusted life-year (QALY) and €80k/QALY, for a population of current and former smokers, aged 50–75 years in The Netherlands. The MAC was estimated based on incremental QALYs gained from a stage shift assuming screened individuals are detected in earlier disease stages. Data were obtained from literature and publicly available statistics and validated with experts.

Results
The MAC per individual for implementing LC screening at a WTP of €20k/QALY was €113. If COPD, CVD, or both were included in screening, the MAC increased to €230, €895, or €971 respectively. Scenario analyses assessed whether screening-specific disease high-risk populations would improve cost-effectiveness, showing that high-risk CVD populations were more likely to improve economic viability compared to COPD.

Conclusions
The economic viability of combined screening is substantially larger than for LC screening alone, primarily due to benefits from CVD screening, and is dependent on the target screening population, which is key to optimise the screening program. The total cost of breast and cervical cancer screening is lower (€420) than the MAC of Big-3, indicating that Big-3 screening may be acceptable from a health economic perspective.

Key Points
• Once-off combined low-dose CT screening for lung cancer, COPD, and CVD in individuals aged 50–75 years is potentially cost-effective if screening would cost less than €971 per screened individual.
• Multi-disease screening requires detailed insight into the co-occurrence of these diseases to identify the optimal target screening population.
• With the same target screening population and WTP, lung cancer-only screening should cost less than €113 per screened individual to be cost-effective.
Performance of current ultrasound-based malignancy risk stratification systems for thyroid nodules in patients with follicular neoplasms
Authors: Lin Yinghe , Lai Shuiqing , Wang Peiqing , Li Jinlian , Chen Zhijiang , Wang Long , Guan Haixia , Kuang Jian 
Published: January 2022

AbstractObjectivesTo investigate the ability of the currently used ultrasound-based malignancy risk stratification systems for thyroid neoplasms (ATA, AACE/ACE/AME, K-TIRADS, EU-TIRADS, ACR-TIRADS and C-TIRADS) in distinguishing follicular thyroid carcinoma (FTC) from follicular thyroid adenoma (FTA). Additionally, we evaluated the ability of these systems in correctly determining the indication for biopsy.MethodsThree hundred twenty-nine follicular neoplasms with definitive postoperative histopathology were included. The nodules were categorized according to each of six stratification systems, based on ultrasound findings. We dichotomized nodules into the positive predictive group of FTC (high and intermediate risk) and negative group of FTC based on the classification results. Missed biopsy was defined as neoplasms that were diagnosed as FTCs but for which biopsy was not indicated based on lesion classification. Unnecessary biopsy was defined as neoplasms that were diagnosed as FTAs but for whom biopsy was considered indicated based on classification. The diagnostic performance and missed and unnecessary biopsy rates were evaluated for each stratification system.ResultsThe area under the curve of each system for distinguishing follicular neoplasms was < 0.700 (range, 0.511–0.611). The missed biopsy rates were 9.0–22.4%. The missed biopsy rates for lesions ≤ 4 cm and lesions sized 2–4 cm were 16.2–35.1% and 0–20.0%, respectively. Unnecessary biopsy rates were 65.3–93.1%. In ≤ 4 cm group, the unnecessary biopsy rates were 62.2–89.7%.ConclusionThe malignancy risk stratification systems can select appropriate nodules for biopsy in follicular neoplasms, while they have limitations in distinguishing follicular neoplasms and reducing unnecessary biopsy. Specific stratification systems and recommendations should be established for follicular neoplasms.Key Points• Current ultrasound-based malignancy risk stratification systems of thyroid nodules had low efficiency in the characterization of follicular neoplasms.• The adopted stratification systems showed acceptable performance for selecting FTC for biopsy but unsatisfactory performance for reducing unnecessary biopsy.
Contribution of fortified margarines and other plant-based fats to micronutrient intake in the Netherlands
Authors: de Jong Marjolein H. , Nawijn Eline L. , Verkaik-Kloosterman Janneke 
Published: January 2022

Abstract

Purpose
In the Netherlands, margarines and other plant-based fats (fortified fats) are encouraged to be fortified with vitamin A and D, by a covenant between the Ministry of Health and food manufacturers. Frequently, these types of fats are also voluntarily fortified with other micronutrients. The current study investigated the contribution of both encouraged as well as voluntary fortification of fortified fats on the micronutrient intakes in the Netherlands.

Methods
Data of the Dutch National Food Consumption Survey (2012–2016; N = 4, 314; 1–79 year.) and the Dutch Food Composition Database (NEVO version 2016) were used to estimate micronutrient intakes. Statistical Program to Assess Dietary Exposure (SPADE) was used to calculate habitual intakes and compared to dietary reference values, separate for users and non-users of fortified fats.

Results
Of the Dutch population, 84% could be considered as user of fortified fats. Users consumed mostly 1 fortified fat a day, and these fats contributed especially to the total micronutrient intake of the encouraged fortified micronutrients (vitamins D and A; 44% and 29%, respectively). The voluntary fortification also contributed to total micronutrient intakes: between 7 and 32%. Vitamin D and A intakes were up to almost double among users compared to non-users. Intakes were higher among users for almost all micronutrients voluntarily added to fats. Higher habitual intakes resulted into higher risks of excessive vitamin A-intakes among boys and adult women users.

Conclusion
Consumption of fortified fats in the Netherlands resulted into higher vitamin A and D-intakes among users, compared to non-users of these products.
Factors affecting the quality of life of gastric cancer survivors
Authors: Choi Jahyun , Kim Sanghee , Choi Mona , Hyung Woo Jin 
Published: January 2022

Abstract
Background
The number of gastric cancer survivors has been increasing, and such survivors experience various changes in their lives post-recovery. Adapting to these changes requires appropriate interventions that can improve their quality of life (QoL). This study was conducted to investigate the factors affecting the QoL of gastric cancer survivors and provide basic data for effective intervention.

Methods
Data were collected between September 8 and September 29, 2017, from the Gastric Cancer Center at a tertiary hospital. Questionnaire surveys were conducted using the EORTC QLQ-C30/STO22, Self-Efficacy-Scale, Multidimensional Scale of Perceived Social Support, and Quality of Life-Cancer Survivors Questionnaire on gastric cancer survivors who were followed up for 3 years after gastrectomy. Data were analyzed using descriptive statistics, t test, ANOVA, Pearson’s correlation coefficient, and multiple regression analysis.

Results
A total of 136 gastric cancer survivors completed the questionnaire survey. There were significant positive correlations of QoL with self-efficacy, functional status, and social support (r = .35, p < .001; r = .53, p < .001; r = .26, p < .001, respectively). There were significant negative correlations of QoL with general symptoms (r =  − .39, p < .001) and gastric cancer-specific symptoms (r =  − .51, p < .001). The regression model explained 48.3% of the QoL, and the affecting factors were gastric cancer-specific symptoms (β =  − .397, p < .001), religious belief (β = .299, p < .001), functional status (β = .251, p = .003), and self-efficacy (β = .191, p = .004).

Conclusion
This study confirmed that gastric cancer-specific symptoms, spiritual well-being, self-efficacy, and functional status affect the QoL of gastric cancer survivors. Hence, these factors should be considered in the interventions to improve the QoL of gastric cancer survivors.
Nocebo effect in multiple system atrophy: systematic review and meta-analysis of placebo-controlled clinical trials
Authors: Wang Zi-Xuan , Zhang Nan-Nan , Zhao Hai-Xia , Song Jie 
Published: January 2022

Abstract
Background
Nocebo effect is prevalent among neurological diseases, resulting in low adherence and treatment outcome. We sought to examine the nocebo effect in randomized controlled trials (RCTs) in multiple system atrophy (MSA).

Methods
We searched RCTs in MSA from Medline since September, 2021. RCTs for drug treatment conducted in adult MSA patients with more than 5 cases in each treatment arm were included. We assessed the number of dropout due to placebo intolerance. We also did a symptomatic/disease-modifying subgroup analysis based on two different treatment purposes. The STATA software was used for statistical analysis. Overall heterogeneity was assessed using the Cochran Q and I2.

Results
Data were extracted from 11 RCTs fulfilling our search criteria. Of 540 placebo-treated patients, 64.2% reported at least one adverse event (AE) and 7.5% reported dropout because of AEs. The chance of dropping out because of an AE and experiencing at least one AE did not differ between placebo and active drug treatment arms. Besides, the pooled nocebo dropout rate in the symptomatic subgroup was similar to that of the disease-modifying subgroup.

Conclusion
In MSA RCTs, nocebo dropout rate was not at a low level among neurological disorders. Nocebo effect was an important reason of dropout because of AE in placebo and active drug treatment arms. Different treatment purposes may not influence nocebo effect.
Significance of upfront cytoreductive nephrectomy stratified by IMDC risk for metastatic renal cell carcinoma in targeted therapy era – a multi-institutional retrospective study
Authors: Kato Renpei , Naito Sei , Numakura Kazuyuki , Hatakeyama Shingo , Koguchi Tomoyuki , Kojima Takahiro , Kawasaki Yoshihide , Kandori Shuya , Kawamura Sadafumi , Arai Yoichi , Ito Akihiro , Nishiyama Hiroyuki , Kojima Yoshiyuki , Ohyama Chikara , Habuchi Tomonori , Tsuchiya Norihiko , Obara Wataru 
Published: January 2022

Abstract
Background
This retrospective multicenter study aimed to evaluate the survival benefit of upfront cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (RCC) patients stratified by International Metastatic RCC Database Consortium (IMDC) risk criteria.

Methods
We reviewed the medical records in the Michinoku Database between 2008 and 2019. Patients who received upfront CN, systemic therapy without CN (no CN) and CN after drug therapy (deferred CN) were analyzed. To exclude selection bias due to patient characteristics, baseline clinical data were adjusted by inverse probability of treatment weighting (IPTW). Overall survival (OS) was compared between upfront CN and non-upfront CN (no CN plus deferred CN). Associations between time-varying covariates including systemic therapies and OS stratified by IMDC risk criteria were analyzed by IPTW-adjusted Cox regression method.

Results
Of 259 patients who fulfilled the selection criteria, 107 were classified in upfront CN and 152 in non-upfront CN group. After IPTW-adjusted analysis, upfront CN showed survival benefit compared to non-upfront CN in patients with IMDC intermediate risk (median OS: 52.5 versus 31.3 months, p < 0.01) and in patients with IMDC poor risk (27.2 versus 11.4 months, p < 0.01). In IPTW-adjusted Cox regression analysis of time-varying covariates, upfront CN was independently associated with OS benefit in patients with IMDC intermediate risk (hazard ratio 0.52, 95% confidence interval 0.29–0.93, p = 0.03) and in patients with IMDC poor risk (0.26, 0.11–0.59, p < 0.01).

Conclusions
Upfront CN may confer survival benefit in RCC patients with IMDC intermediate and poor risk.
Tracing all patients who received insured dialysis treatment in Japan and the present situation of their number of deaths
Authors: Kubo Shinichiro , Noda Tatsuya , Myojin Tomoya , Nishioka Yuichi , Kanno Saho , Higashino Tsuneyuki , Nishimoto Masatoshi , Eriguchi Masahiro , Samejima Kenichi , Tsuruya Kazuhiko , Imamura Tomoaki 
Published: January 2022

Abstract
Background
The survival rate of chronic dialysis patients in Japan remains the highest worldwide, so there is value in presenting Japan’s situation internationally. We examined whether aggregate figures on dialysis patients in the National Database of Health Insurance Claims and Special Health Checkups of Japan (NDB), which contains data on insured procedures of approximately 100 million Japanese residents, complement corresponding figures in the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR).

Methods
Subjects were patients with medical fee points for dialysis recorded in the NDB during 2014–2018. We analyzed annual numbers of dialysis cases, newly initiated dialysis cases– and deaths.

Results
Compared with the JRDR, the NDB had about 6–7% fewer dialysis cases but a similar number of newly initiated dialysis cases. In the NDB, the number of deaths was about 6–10% lower, and the number of hemodialysis cases was lower, while that of peritoneal dialysis cases was higher. The cumulative survival rate at dialysis initiation was approximately 6 percentage points lower in the NDB than in the JRDR, indicating that some patients die at dialysis initiation. Cumulative survival rate by age group was roughly the same between the NDB and JRDR in both sexes.

Conclusion
The use of the NDB enabled us to aggregate data of dialysis patients. With the definition of dialysis patients used in this study, analyses of concomitant medications, comorbidities, surgeries, and therapies will become possible, which will be useful in many future studies.