bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multipoint prediction model for nonlinear displacement of concrete dam
Authors: Yao Kefu , Wen Zhiping , Yang Lifu , Chen Jian , Hou Huiwei , Su Huaizhi 
Published: August 2022

AbstractMeasurement points are installed in concrete dams to monitor nonlinear displacement behavior of dam systems working in complex and aggressive environment. Most modeling works for predicting displacements of these measurement points are limited to single output in point‐by‐point modeling way, with little attention paid to partition‐based multipoint combined modeling. Therefore, a novel multipoint prediction model (MPM) for concrete dam displacement is proposed whose novelty lies in, first, a partition method for measurement points of dam engineering that considers waveform used to identify dam deformation trend and chaos used to describe overall stability and inherent stochasticity in nonlinear displacement series of dam system, and second, a multi‐output support vector machine optimized by an improved grey wolf optimizer with better hierarchy and information transmission. The monitoring data of a super‐high concrete arch dam are used to verify the proposed model. Results indicate that the MPM shows feasibility and generalization capability regarding dam engineering and reaches the performance level of single‐point benchmark models. Robustness, sensitivity, and reasonability of the model are also discussed by random noise, sliding window, and perturbations.
Riboflavin salvage by Borrelia burgdorferi supports carbon metabolism and is essential for survival in the tick vector
Authors: Ramos Darlene , Lasseter Amanda G. , Richards Crystal L. , Schwarz Benjamin , Ghosh Susmita , Victoria Berta , Bosio Catharine M. , Gherardini Frank C. , Jewett Mollie W. 
Published: August 2022

AbstractThe Lyme disease agent, Borrelia burgdorferi, harbors a significantly reduced genome and relies on the scavenging of critical nutrients from its tick and mammalian hosts for survival. Riboflavin salvage has been shown to be important for B. burgdorferi infection of mice, yet the contributions of riboflavin to B. burgdorferi metabolism and survival in the tick remain unknown. Using a targeted mass spectrometry approach, we confirmed the importance of bb0318, the putative ATPase component of an ABC‐type riboflavin transporter, for riboflavin salvage and the production of FMN and FAD. This analysis further revealed that Δbb0318 B. burgdorferi displayed increased levels of glycerol 3‐phosphate compared to the wild‐type. The glycerol 3‐phosphate dehydrogenase activity of GlpD was found to be FAD‐dependent and the transcription and translation of glpD were significantly decreased in Δbb0318 B. burgdorferi. Finally, gene bb0318 was found to be important for maximal spirochete burden in unfed larvae and essential for survival in feeding ticks. Together, these data demonstrate the importance of riboflavin salvage for B. burgdorferi carbon metabolism and survival in ticks.
Comparison of kidney transplant outcomes in HLA compatible and incompatible transplantation: A national cohort study
Authors: Rennie Trijntje J. W. , Battle Richard K. , Abel Angela A. , McConnell Sylvia , McLaren Robert , Phelan Paul J. , Geddes Colin , Padmanabhan Neal , Clancy Marc J. , Little Ann‐Margaret , Turner David M. 
Published: August 2022

AbstractBackgroundReports of HLA incompatible (HLAi) kidney transplant outcomes are inconclusive, especially in the context of lower level Donor Specific Antibodies (DSA).MethodsMulti‐centre national cohort study of HLAi kidney transplant recipients matched in 1:2 ratio with HLA compatible (HLAc) kidney transplant recipients. HLAi defined as DSA identified by Luminex. Antibody mediated rejection (AMR) and transplant‐survival were analysed using Kaplan–Meier plots. Propensity score (PS) matching was used to compare recipient and transplant survival between groups.ResultsWe included 61 HLAi and 122 HLAc recipients; mean age 46 years; 60% female. MFIT0: 3327 (IQR 1352–6458), 23 (38%) were Flow cytometry crossmatch positive (FC‐XMPOS). DSAPOS/FC‐XMPOS transplantation carried an increased risk of AMR at 1 year (52%) compared to DSAPOS/FC‐XMNEG (27%) and HLAc (0%). Unadjusted death censored graft loss at 3 years was 13% (HLAi) and 8% (HLAc). Three‐year patient survival was 95% in HLAc, 84% in DSAPOS/FC‐XMNEG and 69% in DSAPOS/FC‐XMPOS recipients; 58% of HLAi deaths were infection‐related. HLA incompatibility was associated with a decreased 3‐year survival in our PS‐matched cohort.ConclusionIn kidney transplantation, DSA and positive FC‐XM carries an increased risk of AMR. Despite inferior transplant and survival outcomes compared to HLAc transplantation, it remains a realistic option for highly sensitized patients facing prolonged waiting times and reduced survival on dialysis.
Comparative transcriptomics and metabolomics reveal specialized metabolite drought stress responses in switchgrass (Panicum virgatum)
Authors: Tiedge Kira , Li Xingxing , Merrill Amy T. , Davisson Danielle , Chen Yuxuan , Yu Ping , Tantillo Dean J. , Last Robert L. , Zerbe Philipp 
Published: August 2022

Summary

Switchgrass (Panicum virgatum) is a bioenergy model crop valued for its energy efficiency and drought tolerance. The related monocot species rice (Oryza sativa) and maize (Zea mays) deploy species‐specific, specialized metabolites as core stress defenses. By contrast, specialized chemical defenses in switchgrass are largely unknown.

To investigate specialized metabolic drought responses in switchgrass, we integrated tissue‐specific transcriptome and metabolite analyses of the genotypes Alamo and Cave‐in‐Rock that feature different drought tolerance.

The more drought‐susceptible Cave‐in‐Rock featured an earlier onset of transcriptomic changes and significantly more differentially expressed genes in response to drought compared to Alamo. Specialized pathways showed moderate differential expression compared to pronounced transcriptomic alterations in carbohydrate and amino acid metabolism. However, diterpenoid‐biosynthetic genes showed drought‐inducible expression in Alamo roots, contrasting largely unaltered triterpenoid and phenylpropanoid pathways. Metabolomic analyses identified common and genotype‐specific flavonoids and terpenoids. Consistent with transcriptomic alterations, several root diterpenoids showed significant drought‐induced accumulation, whereas triterpenoid abundance remained predominantly unchanged. Structural analysis verified select drought‐responsive diterpenoids as oxygenated furanoditerpenoids.

Drought‐dependent transcriptome and metabolite profiles provide the foundation to understand the molecular mechanisms underlying switchgrass drought responses. Accumulation of specialized root diterpenoids and corresponding pathway transcripts supports a role in drought stress tolerance.
Anatomy of a justified sinner in Sartre's “L'enfance d'un chef” through the object‐relations psychology
Authors: Dalmas Franck 
Published: August 2022

AbstractJean‐Paul Sartre coined a psychoanalytic method in his biographical works to evidence existential choices while distancing himself from Freudian models. The novella “L'enfance d'un chef” (1939) is the pretext to explore the life plan of an individual prone to schizoid syndromes due to his upbringing and social binds. This article examines the itinerary of Lucien Fleurier through his misconstrued edification and empowerment, stemming from childhood fallacies, anxiety buildup, and ego splitting. The maturing process in his life story would assuredly reveal the emergence of Sartre's existential psychoanalysis. My vantage point, however, tackles striking similarities with a concurrent psychoanalytic revision, the object‐relations theory, articulated by W. R. D. Fairbairn in the 1940s. It is my contention that this original and coincidental endopsychic structure proposes a remarkable parallel for the errant choices in Sartre's antihero.
Effect of C1 Single‐door Laminoplasty on Symptomatic Atlas Canal Stenosis
Authors: Chen Linwei , Zhu Xiuliang , He Bin , Chen Qixin , Li Fangcai 
Published: August 2022

ObjectiveTo verify the effect of single‐door laminoplasty combined with atlantoaxial fusion in the treatment of symptomatic atlas canal stenosis.MethodsThis is a single‐center retrospective analysis. From February 2014 to January 2019, 16 patients (five were females) with an average age of 63.4 years (56–71 years) were enrolled in this study. Patients with compressive cervical myelopathy with CT scan showed an inner sagittal diameter (ISD) of C1 less than 29 mm or C1 canal space available for cord (SAC) of <12 mm were included, while isolated C1 stenosis without myelopathy or isolated C1 stenosis without atlantoaxial subluxation were excluded in this study. All patients underwent continuous heavy‐weight skull traction, atlas single‐door laminoplasty and atlantoaxial fusion. The differences in the pre‐ and post‐operative inner sagittal diameter, space available for cord, atlas‐dens interval (ADI) and compression of the spinal cord were analyzed by using CT and MRI. Functional evaluation was performed by using the Japanese Orthopaedic Association scoring system and the Neck Disability Index scoring system.ResultsSingle‐door laminoplasty provided a full decompression for the spinal cord while retaining the whole posterior arch. No complications were encountered except a superficial wound infection in one patient. At final follow‐up, The ADI was significantly reduced from 5.2 ± 1.8 mm to 1.7 ± 0.6 mm after surgery on average (P < 0.05). Average inner sagittal diameter of C1 was increased from 26.3 ± 2.6 mm to 34.9 ± 2.9 mm and the space available for cord was increased from 6 ± 1.7 mm to 17.8 ± 3.6 mm (P < 0.05). Meanwhile, the Japanese Orthopaedic Association (JOA) score of the 16 cases was improved from 11.4 ± 1.8 to 14.1 ± 1.4 on average (P < 0.05). The postoperative neck pain VAS score decreased significantly, from 2.6 ± 1.0 preoperatively to 1.3 ± 0.9 postoperatively (P < 0.05). The influence of neck pain on patient's life was improved from 17.8 ± 3.9 to 13.9 ± 3.3 after surgery (P < 0.05). At the last follow‐up, the healing of the hinge fracture and the fusion between atlas and axis were observed in all patients.ConclusionsSingle‐door laminoplasty combined with atlantoaxial fusion not only provides enough space for decompression but also offers intact arch for bone grafting, suggesting that it might provide a more feasible method for the correction of symptomatic atlas canal stenosis.
Pulsed electrical field in arrhythmia treatment: Current status and future directions
Authors: Qiu Jie , Lan Lan , Wang Yan 
Published: August 2022

AbstractPulsed electrical field (PEF) ablation is a promising novel ablation modality for the treatment of arrhythmia, especially for atrial fibrillation (AF). There have been several important advances in PEF ablation over the past several years, such as the parameters of PEF delivery and electrode Design. And the results in almost all clinical studies of PEF for AF ablation are optimistic, both in terms of effectiveness and safety. This article provides a brief overview of the mechanism and technical progress of PEF ablation in cardiac arrhythmia treatment, and discuss it’s potential applications and the future development.
Self‐reported pain during the initial postoperative period following open lumbar spine fusion surgery does not correlate with the number of levels fused: A prospective trial of 40 patients
Authors: Shani Adi , Baron Shahaf Dana , Ciubotaru Dan , Rod Alon , Rahamimov Nimrod 
Published: August 2022

AbstractBackgroundCurrent spine postoperative pain control protocols consider the expected pain following spine fusion surgery to correlate with surgical extent, that is, the greater the number of operated vertebrae, the greater the postoperative pain. Due to this assumption, Enhanced Recovery After Surgery (ERAS) protocols are principally applied to minimally invasive and percutaneous spine surgery and less to open extensive spine fusion operations. The aim of this study was to determine whether postoperative pain does in fact correlate with the surgical extent, potentially opening the door to non‐narcotic postoperative pain protocols for this patient subset.Materials and methodsForty consecutive patients, undergoing open posterior spine surgery, were evaluated for postoperative pain during the first 72 after surgery. All patients were then divided into two groups according to the number of spine levels fused, and the correlation between the number of fusion levels and self‐reported pain was analyzed statistically.ResultsSelf‐reported pain levels were not found to correlate with the extent of the spine operation.ConclusionsAs “bigger operation” does not necessarily equate with “bigger pain,” adequate postoperative pain control after extensive spine fusion surgery might be achieved without the routine use of narcotic medication, as practiced after minimally invasive and percutaneous surgery. Additional prospective randomized trials are needed to further substantiate this conclusion.
Health situation and perceived health status among women experiencing homelessness: A longitudinal study in Spain
Authors: Lenta Malena , Panadero Sonia , Cabrera Adrian , Vázquez José Juan 
Published: August 2022

AbstractThe paper analyses the health situation and the perceived health status of a sample of women experiencing homelessness (n = 138) in Madrid, Spain. All participants were adults, and the night before the baseline interview, they had slept on the street, at a shelter or any facility provided to care for people living homeless. The information was collected using structured interviews, repeated twice a year for a 3‐year follow‐up period. The findings of this study show that women experiencing homelessness presented poor health, particularly in comparison with the general Spanish population. Over half of the women questioned claimed to have a diagnosed serious or chronic illness, with a correlation between these conditions and the age, time spent homeless or high levels of drug use. There was a positive correlation found between women's perceived health status and being younger and having access to independent accommodation, while having suffered a number of stressful life events and having spent long periods of time living homeless presented a negative correlation with a good perceived health status.
Power Line Extraction and Obstacle Inspection of Unmanned Aerial Vehicle Oblique Images Constrained by the Vertical Plane
Authors: Li Cailin , Zhu Fuhong , Guo Baoyun , Wang Zhiyong , Jiang Xiaobin , Wang Jiawen , Liao Xiangcan 
Published: August 2022

AbstractUnmanned aerial vehicle (UAV) inspection of vegetation or other obstacles in power transmission line corridors is an economical and efficient method. Spatial power lines cannot be directly restored in the single airborne photographic geometry, and automatic robust extraction of power lines under complex background is a bottleneck problem in the current transmission line reconstruction. Thus, a robust restoration method of the power line spatial position based on the vertical plane constraint was proposed that can restore the entire power line three‐dimensional (3D) points. First, the spatial position of the hanging points at both ends of the power line was solved based on an insulator plumb, and the vertical plane of the power line was determined. A light beam passing through the photographing centre and the image point could then be determined for any image point on the image power line. The intersection point of the light beam and the vertical plane of the power line was the point of the spatial power line. The proposed method was used to select a few (three or more) power line seed points manually to calculate the corresponding 3D space points and then fit these points to obtain the dense and uniform 3D points of power line. After restoring the spatial power line, the minimum distance error line segment based on splitting was used to approximate the 3D point sequence of the power line, and it was divided into several straight‐line segments. The spatial buffer zone was established with each line segment as the centre and a safety distance as the radius to detect possible obstacles in the power line corridor. Finally, a set of simulated and actual data were used for verification and analysis. Results show that the method can effectively detect obstacles around the power line, and the accuracy is within 0.25 m.
Ultraviolet Radiation Exposure and its Impacts on Cutaneous Phosphorylation Signaling in Carcinogenesis: Focusing on Protein Tyrosine Phosphatases†
Authors: Asare Obed , Ayala Yasmin , Hafeez Bilal Bin , Ramirez‐Correa Genaro A. , Cho Yong‐Yeon , Kim Dae Joon 
Published: August 2022

ABSTRACTSunlight exposure is a significant risk factor for UV‐induced deteriorating transformations of epidermal homeostasis leading to skin carcinogenesis. The ability of UVB radiation to cause melanoma, as well as basal and squamous cell carcinomas, makes UVB the most harmful among the three known UV ranges. UVB‐induced DNA mutations and dysregulation of signaling pathways contribute to skin cancer formation. Among various signaling pathways modulated by UVB, tyrosine phosphorylation signaling which is mediated by the action of protein tyrosine kinases (PTKs) on specific tyrosine residues is highly implicated in photocarcinogenesis. Following UVB irradiation, PTKs get activated and their downstream signaling pathways contribute to photocarcinogenesis by promoting the survival of damaged keratinocytes and increasing cell proliferation. While UVB activates oncogenic signaling pathways, it can also activate tumor suppressive signaling pathways as initial protective mechanisms to maintain epidermal homeostasis. Tyrosine dephosphorylation is one of the protective mechanisms and is mediated by the action of protein tyrosine phosphatases (PTPs). PTP can counteract UVB‐mediated PTK activation and downregulate oncogenic signaling pathways. However, PTPs have not been studied extensively in photocarcinogenesis with previous studies regarding their inactivation induced by UVB. This current review will summarize the recent progress in the protective function of PTPs in epidermal photocarcinogenesis.
Still a poster child for social investment? Changing regulatory dynamics of early childhood education and care in Denmark and Sweden
Authors: de la Porte Caroline , Larsen Trine P. , Lundqvist Åsa 
Published: August 2022

AbstractThis paper investigates the regulation of publicly organized early childhood education and care (ECEC) in Denmark and Sweden, through the regulatory welfare state (RWS) framework. The analysis focuses on how alterations in funding and quality of care are shaped by governmental and nongovernmental actors at national and local levels of government. Through focused structured analysis, we examine how various actors have shaped the funding and quality of childcare in Denmark and Sweden, from the early 2000s to 2020, with special attention to the period during and after the 2008 financial crisis. In the aftermath of the financial crisis, concerns about quality in care were raised on the political agenda by various actors in both countries, leading to decisions to improve the quality of care. Yet, the regulatory dynamics differ: In Denmark, the debate led to a decision in 2019, to implement a minimum statutory requirement of regulatory quality standards. From an RWS perspective, this outcome can be qualified as “double expansion,” because regulatory quality standards, and public funding for childcare increased. In Sweden, the debates about quality of ECEC led, in 2016, to political guidelines about quality standard, but with no additional national funds, and no mandatory regulatory quality requirements. Analytically, this can be qualified as “regulatory‐led expansion,” that is requirements for quality standards, although the lack of additional national funds suggests that it will be difficult to improve ECEC quality substantially. The RWS perspective, which focuses on national and municipal levels of governance, also gives insights into hidden inequalities between municipalities regarding funding and quality of ECEC, which are more pronounced in Sweden than in Denmark.
Does combining traditional and information and communications technology–based extension methods improve agricultural outcomes? Evidence from field experiments in Mali
Authors: Dzanku Fred Mawunyo , Osei Robert Darko 
Published: August 2022

AbstractAdequate flow of appropriate information to farmers is vital for accelerating the uptake of modern agricultural technologies and improving access to markets, all of which are important for the transformation of African economies. Yet there is limited evidence regarding how information should be disseminated to farmers to achieve the needed impact. Should ICT‐based approaches be used together with traditional methods, or should they be used alone? We used cluster quasi‐random and randomized experiments involving 140 villages in southern Mali to study three chains of causality: does farmer training increase knowledge? Does knowledge lead to change in behavior? Do the different actions generate varying economic outcomes? We show that the role of farmer training in the uptake of extension advice may be overstated in some settings; that procrastination and inattention are more binding constraints to recommendation adherence than information per se; and that such constraints could be mitigated by timely voice SMS reminders. Although timely reminders nudged farmers to take‐up recommendations, leading to meaningful improvements in some intermediate outcomes, these impacts were not large enough to generate improvements in output, prices and profits in the short term. These findings must be interpreted within the context of imperfect compliance with experimental protocols, which pose threats to both the internal and external validity of some of the impact estimates.
Self‐reported dental attendance, oral hygiene habits, and dietary habits of adults with cystic fibrosis
Authors: Coffey Niamh , O’ Leary Fiona , Burke Francis , Plant Barry , Roberts Anthony , Hayes Martina 
Published: August 2022

AbstractAimsTo evaluate the dental attendance, oral hygiene habits, and dietary habits of adults with Cystic Fibrosis in the Republic of Ireland.Methods and ResultsA cross‐sectional study was carried out using a structured anonymous questionnaire. A total of 71 adults with Cystic Fibrosis responded. While the majority of respondents (66.2%) saw a dentist in the preceding year, 15.5% had not attended a dentist for over 2 years. Smoking and alcohol consumption levels were low. 63.4% brushed twice or more daily, with 70.4% using a Fluoride containing toothpaste. 62% did not use any interdental cleaning aid. 5.6% changed their toothbrush at least once a month, but for 22.5% it was over 6 months. 70.4% used fluoride toothpaste. 38% snacked three or more times daily and 29.5% consumed fizzy drinks at least once daily.ConclusionsThe alcohol and tobacco consumption in this study group was low. However, a large proportion frequently consumed sugar‐rich foods, and they did not change their toothbrush, brush their teeth, or attend the dentist as regularly as is advised. More targeted advice may be necessary to improve the oral hygiene habits of adults with Cystic Fibrosis.