bluuebunny/crossref_metadata_2025_split huggingface dataset:
Criteria and methodologies for determining the causes of swelling of canned tomatoes in tinplate containers
Authors: Squitieri Giuseppe , Pirone Giuseppe , La Pietra Liliana , Cannavacciuolo Mariarosaria , Pezzani Aldo , Ferrari Giovanna , Castaldo Domenico , Balestrieri Maria Luisa , Cautela Domenico 
Published: December 2022

AbstractThis review provides the current laboratory criteria for the detection and evaluation of the possible causes of alteration of non‐concentrated industrial derivatives of tomatoes (peeled tomatoes, pulps, purees, sauces, and fillets), packaged in coated or uncoated tinplate cans. We discuss how the product alterations are typically the consequence of technological errors either in the can production, or in the storage process, or in the product sterilization. The described procedures include the quantitative determination of the distribution of gases (H2, CO2, N2, and O2) present in the headspace of the container. The gas composition and ratios can be used as markers to allow easy diagnosis of the causes of microbiologic and/or physical–chemical alterations of the tomatoes, which are usually made evident by swelling of the containers. These tests should be integrated by microbiological analyses aimed at a restricted group of microorganisms, with the chemical analysis of the container and the chemical analysis of the altered product. By way of example, we report the assessment of the causes of alteration in four different case‐studies.
Dry surface biofilms in the food processing industry: An overview on surface characteristics, adhesion and biofilm formation, detection of biofilms, and dry sanitization methods
Authors: Alonso Vanessa Pereira Perez , Gonçalves Maria Paula M. B. B. , de Brito Francisca Airlane Esteves , Barboza Giovana Rueda , Rocha Liliana de Oliveira , Silva Nathalia Cristina Cirone 
Published: December 2022

AbstractBacterial biofilm formation in low moisture food processing (LMF) plants is related to matters of food safety, production efficiency, economic loss, and reduced consumer trust. Dry surfaces may appear dry to the naked eye, however, it is common to find a coverage of thin liquid films and microdroplets, known as microscopic surface wetness (MSW). The MSW may favor dry surface biofilm (DSB) formation. DSB formation is similar in other industries, it occurs through the processes of adhesion, production of extracellular polymeric substances, development of microcolonies and maturation, it is mediated by a quorum sensing (QS) system and is followed by dispersal, leading to disaggregation. Species that survive on dry surfaces develop tolerance to different stresses. DSB are recalcitrant and contribute to higher resistance to sanitation, becoming potential sources of contamination, related to the spoilage of processed products and foodborne disease outbreaks. In LMF industries, sanitization is performed using physical methods without the presence of water. Although alternative dry sanitizing methods can be efficiently used, additional studies are still required to develop and assess the effect of emerging technologies, and to propose possible combinations with traditional methods to enhance their effects on the sanitization process. Overall, more information about the different technologies can help to find the most appropriate method/s, contributing to the development of new sanitization protocols. Thus, this review aimed to identify the main characteristics and challenges of biofilm management in low moisture food industries, and summarizes the mechanisms of action of different dry sanitizing methods (alcohol, hot air, UV‐C light, pulsed light, gaseous ozone, and cold plasma) and their effects on microbial metabolism.
Antiviral function of peptidoglycan recognition protein in Spodoptera exigua (Lepidoptera: Noctuidae)
Authors: Li Jie , Li Jie , Jing Zhaohao , Yu Qianlong , Zheng Guiling , Zhang Bin , Xing Longsheng , Zhang Huan , Wan Fanghao , Li Changyou 
Published: December 2022

AbstractPeptidoglycan recognition proteins (PGRPs) are a class of molecules that play a critical role in insect immunity. Understanding the function of PGRPs is important to improve the efficiency of microbial insecticides. In this study, we investigated the role of PGRP‐LB (a long type PGRP) in insect immunity against viruses using Spodoptera exigua and Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) as an insect–virus model. We cloned and identified a PGRP‐LB gene from S. exigua; the gene consisted of 7 exons that encoded a polypeptide of 234 amino acids with a signal peptide and a typical amidase domain. Expression analysis revealed that the abundance of SePGRP‐LB transcripts in the fat body was greater than in other tissues. Overexpression of SePGRP‐LB resulted in a significant decrease of 49% in the rate of SeMNPV‐infected cells. In addition, the multiplication of SeMNPV was significantly decreased: a decrease of 79% in the production of occlusion‐derived virion (ODV), and a maximum decrease of 50% in the production of budded virion (BV). In contrast, silencing of SePGRP‐LB expression by RNA interference resulted in a significant 1.65‐fold increase in the rate of SeMNPV‐infected cells, a significant 0.54‐fold increase in ODV production, a maximum 1.57‐fold increase in BV production, and the larval survival dropped to 21%. Our findings show that SePGRP‐LB has an antiviral function against SeMNPV, and therefore this gene may provide a target for lepidopteran pest control using virus insecticides.
Beyond cholesterol—pleiotropic effects of lipoprotein apheresis
Authors: Schettler Volker J. J. , Schettler Elke 
Published: December 2022

AbstractCardiovascular disease is a leading cause of mortality worldwide, which is caused mainly by atherosclerosis, a chronic inflammatory disease of blood vessels. Therefore, atherosclerosis represents a complex disorder, which induces damage or imbalance on different levels: for example, genes, cytokines, lipoproteins, cells, vessels, and organs. Lipoprotein apheresis (LA) is a well‐established extracorporeal treatment of severe hyperlipoproteinemia. In addition, LA may have simultaneously crucial effects on many other atherogenic factors during the treatments, for example, as vascular inflammation, rheology, mobilization of adult stem cells and gene expressions in blood or endothelial cells, which will be discussed in this short review. In addition, stable microRNAs besides tissues also appear in extracellular compartments, for example, vessels, involved in atherosclerotic processes, were found to be reduced by LA treatments. In summary, LA represents a complex therapeutic procedure, that provides an ideal tool for the treatment of complex disorders such as atherosclerosis.
Consumer acceptance of reduced sodium white and multigrain bread: Impact of flavor enhancement and ingredient information on sample liking
Authors: Dunteman Aubrey N. , Lee Soo‐Yeun 
Published: December 2022

AbstractChronic consumption of sodium in quantities exceeding recommendations has led to sodium being designated as a nutrient of health concern for overconsumption. As a result of the prevalence of sodium overconsumption, the Food and Drug Administration (FDA) released voluntary sodium reduction goals for a wide variety of products on both short‐ and long‐term timespans. As food palatability may decrease when sodium is reduced, flavor enhancers such as monosodium glutamate (MSG) may provide a promising solution to mitigate such palatability loss. The objective of this research was to investigate consumer acceptance of white and multigrain breads with either a 43% or 60% reduction in sodium content and with and without MSG as well as to investigate the influence of information on consumer acceptance of these breads under blind, informed, and informed with education conditions. Seventy‐eight frequent bread consumers participated in the evaluations. A significant difference was evidenced across breads with different levels of sodium content and MSG status, although no difference was seen across the different evaluation conditions. Consumer segmentation found multiple consumer clusters showing different liking patterns of the bread treatments for both white and multigrain breads. Breads with sodium content set at the FDA's long‐term goal with and without MSG were liked no differently in nearly all attributes evaluated than the full‐sodium bread demonstrating the feasibility of producing acceptable reduced‐sodium breads. Future research characterizing the predominant sensory attributes of full‐sodium and reduced‐sodium breads with and without MSG would be valuable for identifying the drivers of liking in such products.Practical Application: The findings of our study suggest that consumer liking of reduced sodium white and multigrain breads could be improved with the addition of monosodium glutamate. Increasing the acceptance of reduced sodium food products could help to reduce the risk of hypertension and subsequently heart attacks and stroke for the American population.
Current approaches on the roles of lactic acid bacteria in crop silage
Authors: Guo Xusheng , Xu Dongmei , Li Fuhou , Bai Jie , Su Rina 
Published: December 2022

AbstractLactic acid bacteria (LAB) play pivotal roles in the preservation and fermentation of forage crops in spontaneous or inoculated silages. Highlights of silage LAB over the past decades include the discovery of the roles of LAB in silage bacterial communities and metabolism and the exploration of functional properties. The present article reviews published literature on the effects of LAB on the succession, structure, and functions of silage microbial communities involved in fermentation. Furthermore, the utility of functional LAB in silage preparation including feruloyl esterase‐producing LAB, antimicrobial LAB, lactic acid bacteria with high antioxidant potential, pesticide‐degrading LAB, lactic acid bacteria producing 1,2‐propanediol, and low‐temperature‐tolerant LAB have been described. Compared with conventional LAB, functional LAB produce different effects; specifically, they positively affect animal performance, health, and product quality, among others. In addition, the metabolic profiles of ensiled forages show that plentiful probiotic metabolites with but not limited to antimicrobial, antioxidant, aromatic, and anti‐inflammatory properties are observed in silage. Collectively, the current knowledge on the roles of LAB in crop silage indicates there are great opportunities to develop silage not only as a fermented feed but also as a vehicle of delivery of probiotic substances for animal health and welfare in the future.
Lake management under severe drought: Lake Mead, Nevada/Arizona
Authors: Hannoun Deena , Tietjen Todd 
Published: December 2022

AbstractDrought can affect both the quantity and quality of water in lakes and reservoirs, yet larger, highly managed waterbodies, such as Lake Mead, may be somewhat buffered from drought effects. From 2000 to present, Lake Mead has experienced a 71% decline in volume; however, influent water quality has remained high and consistent outflow volumes through Hoover Dam have been maintained. Furthermore, management activities, such as increased removal of phosphorus by wastewater dischargers and legacy contamination cleanup efforts, have been initiated since the drought began. These efforts have led to small improvements in values of water quality parameters, such as phosphorus, nitrogen, and perchlorate, despite loss of volume for dilution of constituents, and consequently, decreased residence time. As the drought continues, Lake Mead is projected to continue declining in volume, inflows are projected to become warmer, and the population of Las Vegas is projected to grow, potentially adding additional stress to the hydrologic system. Maintenance of outflow may mitigate some potentially negative consequences, and understanding the drivers behind continued high water quality despite prolonged drought is important to continue to maintain the health and vitality of the entire Lower Colorado River Basin.
The ‘question of possibilities’ as a leitmotif for re‐imagining law for the ‘Anthropocene’
Authors: Mai Laura 
Published: December 2022

AbstractThe Anthropocene thesis, albeit not an unproblematic starting point, foregrounds the inadequacy of tacitly reproduced assumptions, theoretical dispositions, and conceptual repertoires which have supported a critical mass of legal thinking and praxis. Acknowledging the disruptive effects of the ‘Anthropocene’ for law, my aim in this article is to make explicit that re‐imagining law for the Anthropocene requires letting go of dominant ways of thinking and doing law, while enabling more adequate conceptions and modes of engagement to take hold. I suggest that the process of re‐imagining law for the Anthropocene requires navigating a space of continuity and break that demands the legal discipline to confront questions about disciplinary identity and responsibility. Reflecting on what the process of re‐imagining law might entail and how it could unfold, I propose the ‘question of possibilities’ as a leitmotif and ask: What could law become? In so doing, I map out concrete strategies and commitments which might inspire and encourage engagement with this question. These include: a practice of radical self‐reflection, the cultivation of a generative outlook, the acknowledgement of legal multiplicity, and a persistent commitment to meaningful change.
Knowledge governance for the Anthropocene: Pluralism, populism, and decision‐making
Authors: Clement Sarah 
Published: December 2022

AbstractMany new models of governance are presented as offering potential to more effectively confront environmental challenges in the Anthropocene by transforming the underlying logic of decision‐making. A common feature of these models is the imperative to integrate multiple forms of knowledge, disciplinary perspectives, and diverse networks of actors both within and outside the academy. These calls for pluralism are not just about it as a democratic principle, but part of improved ‘knowledge governance’ more equipped to address the multi‐faceted causes and consequences of environmental degradation. Yet the principles behind these improved practices can be lost in translation. While pluralism is elevated as ideal, when decision‐makers are faced with political and social realities of bringing in more voices, the result is often more populist than pluralist, and conflicts difficult to manage. This paper explores how these issues play out by examining co‐production in Australian wildfire governance, revealing concerns about whose knowledge is considered credible and legitimate and how knowledge is used to bolster narratives about both change and the status quo. It also contributes to debates about how populism influences the use of knowledge in policy, and how values influence interpretation and action in relation to new evidence.
Acetyltransferase p300 regulates atrial fibroblast senescence and age‐related atrial fibrosis through p53/Smad3 axis
Authors: Gao Xiao‐Yan , Lai Ying‐Yu , Luo Xue‐Shan , Peng De‐Wei , Li Qiao‐Qiao , Zhou Hui‐Shan , Xue Yu‐Mei , Guo Hui‐Ming , Zhao Jun‐Fei , Yang Hui , Kuang Su‐Juan , Wang Zhao‐Yu , Zhang Meng‐Zhen , Deng Chun‐Yu , Wu Shu‐Lin , Rao Fang 
Published: December 2022

AbstractAtrial fibrosis induced by aging is one of the main causes of atrial fibrillation (AF), but the potential molecular mechanism is not clear. Acetyltransferase p300 participates in the cellular senescence and fibrosis, which might be involved in the age‐related atrial fibrosis. Four microarray datasets generated from atrial tissue of AF patients and sinus rhythm (SR) controls were analyzed to find the possible relationship of p300 (EP300) with senescence and fibrosis. And then, biochemical assays and in vivo electrophysiological examination were performed on older AF patients, aging mice, and senescent atrial fibroblasts. The results showed that (1) the left atrial tissues of older AF patients, aging mouse, and senescence human atrial fibroblasts had more severe atrial fibrosis and higher protein expression levels of p300, p53/acetylated p53 (ac‐p53)/p21, Smad3/p‐Smads, and fibrosis‐related factors. (2) p300 inhibitor curcumin and p300 knockdown treated aging mouse and senescence human atrial fibroblasts reduced the senescence ratio of atrial fibroblasts, ameliorated the atrial fibrosis, and decreased the AF inducibility. In contrast, over‐expression of p300 can lead to the senescence of atrial fibroblasts and atrial fibrosis. (3) p53 knockdown decreased the expression of aging and fibrosis‐related proteins. (4) Co‐immunoprecipitation and immunofluorescence showed that p53 forms a complex with smad3 and directly regulates the expression of smad3 in atrial fibroblasts. Our findings suggest that the mechanism of atrial fibrosis induced by aging is, at least, partially dependent on the regulation of p300, which provides new sights into the AF treatment, especially for the elderly.
Epirubicin may enhance the inhibition of hepatocellular carcinoma induced by iodine‐125 seeds through downregulating WNT pathway
Authors: Tian Shilin , Lu Yue , Gao Haifeng , Chen Zitong , Niu Min , Wang Changjun , Liu Bin 
Published: December 2022

AbstractAimTo investigate the role of iodine‐125 (125I) combined with epirubicin (EPI) in inhibiting hepatocellular carcinoma (HCC) growth and promoting apoptosis.MethodsBoth in vivo and in vitro experiments were conducted. CCK‐8 assay was performed to determine the cells viability after EPI treatment. HepG2 and SMMC7721 cells were treated with EPI or 125I or in combination. Colony formation assays were performed to verify the antiproliferation effect. Annexin V–FITC/PI, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays, and western blotting were performed to analyze cellular apoptosis. Scratch wound healing assays and transwell assays were used to examine migration following different treatments. An isobaric tag for relative and absolute quantitation analysis was used to detect changes in protein expression after 125I treatment, identifying the potential mediating protein cathelicidin (LL‐37). LL‐37 protein and WNT pathway‐related proteins were detected by western blotting in SMMC7721 and HepG2 cells. Mice were treated with 125I and EPI to evaluate whether EPI enhanced the antitumor effect of 125I.ResultsEPI promoted 125I‐induced apoptosis and reduced the proliferation of HepG2 and SMMC7721 cells. EPI also prevented the migration of HepG2 and SMMC7721 cells. EPI combined with 125I may interfere with the WNT signaling pathway by decreasing LL‐37 to inhibit HCC development. The antitumor effects of EPI with 125I were verified in mice.ConclusionEPI combined with 125I induced apoptosis and inhibited the proliferation of HCC cells by LL‐37 downregulating the WNT pathway.
The story of this special issue on critical perspectives in work and organizational psychology
Authors: Abrams Ruth , Bal P. Matthijs , D'Cruz Premilla , Hornung Severin , Islam Gazi , McDonald Matthew , Sanderson Zoe , Tonelli Maria José 
Published: December 2022

AbstractIn this editorial, we tell the story of how the Special Issue on Critical Perspectives in Work and Organizational Psychology (CWOP) came about, how it fits within the broader agenda of building a critical community within Work and Organizational Psychology, and how future research and thought may be inspired by the collection of critical papers related to work and organizational psychology. We introduce the term “criticalizing” as a key concept in how the Special Issue was developed by the editorial team and the authors. Criticalizing moves beyond fixed static notions of “critical” scholarship toward a process of engaging in more fluid, expansive, and creative perspectives on the scholarship within work and organizational psychology. We illustrate how the set of papers within the Special Issue engages in such criticalizing of the field and offer new ways of thinking about and researching relevant topics in work and organizational psychology.
Editorial: safety and efficacy of infliximab and corticosteroids in checkpoint inhibitor‐induced colitis—authors' reply
Authors: Dahl Emilie K. , Abed Osama K. , Kjeldsen Jens , Donia Marco , Svane Inge M. , Dige Anders , Agnholt Jørgen S. , Bjerrum Jacob T. , Seidelin Jakob B. 
Published: December 2022

LINKED CONTENTThis article is linked to Dahl et al papers. To view these articles, visit https://doi.org/10.1111/apt.17201 and https://doi.org/10.1111/apt.17237
Genetic relationships among emu populations in Japanese farms based on mitochondrial and microsatellite DNA polymorphisms
Authors: Koshiishi Yuichi , Murata‐Okubo Michiko , Kameyama Yuichi , Souma Kousaku , Hirayama Hiroki , Wada Kenta 
Published: December 2022

AbstractEmus (Dromaius novaehollandiae) are expected to become a novel poultry species for producing eggs, meat, and oil. In our previous studies, Japanese emu populations were predicted to have reduced genetic diversity through inbreeding. For a sustainable emu industry in Japan, it is necessary to understand the current genetic structure and relationships in dispersed farms. In this study, we investigated the genetic structure and relationships of six Japanese emu farms based on mitochondrial DNA and microsatellite polymorphisms. We analyzed the DNA sequences of the mitochondrial D‐loop region in 157 individuals and detected four haplotypes with four nucleotide substitution sites (Hap‐a, Hap‐b, Hap‐c, and Hap‐d). Analysis of molecular variance revealed that 43.6% of total variance was “among population,” and the FST value was 0.436 with significant genetic differentiation (P < 0.001). In microsatellite analysis, the expected (HE) and observed (HO) heterozygosities were 0.53–0.64 and 0.44–0.59, respectively. Phylogenetic trees and STRUCTURE analysis revealed that the six Japanese farmed emu populations could be divided into four genetically differentiated groups. Therefore, we identified genetic resources that may be useful in extending the genetic diversity of Japanese farms and are predicted to contribute to the conservation and reconstruction of populations.
Through thick and thin: The moment of meaning as a boundary object
Authors: Zasa Federico P. , Artusi Federico , Verganti Roberto 
Published: December 2022

During the front end of innovation, teams embody abstract meanings into product concepts. The literature on Innovation of Meaning suggests that focusing on a single product‐user interaction supports this process. This Moment of Meaning facilitates the development of shared meaning and knowledge. We explore how the Moment of Meaning acts as a Boundary Object to support the innovation process.We study six Innovation of Meaning projects in different companies to explore how the Moment of Meaning supports the transition from abstract meaning to a concrete solution. Attending company meetings and workshops, we collected extensive qualitative data on the usage of the Moment of Meaning.We identify four uses of the Moment of Meaning. Depending on its degree of abstraction and perspective, it represents a Metaphor, a Product Vision, a Core Feature or an Experience Concept. Our study sheds light on the reification of meanings in early stages of innovation. Also, we highlight the potential evolution of Boundary Objects over time. To managers, we provide actionable knowledge on how a simple boundary object could ease the transition from an innovation strategy to a concrete product concept.