bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paramonostomum deseado n. sp. (Digenea: Notocotylidae) parasitizing the South American Black Oystercatcher and their atypical life cycle from the Patagonian coast
Authors: Bagnato Estefanía , Gilardoni Carmen , Lauthier Juan José , Cremonte Florencia 
Published: August 2022

AbstractBy way of morphological and molecular analysis we describe a new species of notocotylid, Paramonostomum deseado n. sp., parasitizing Haematopus ater from Argentina and we contribute to elucidate its life cycle. Within this genus, 4 groups can be morphologically distinguished according to body shape: ‘Oval’, ‘Pyriform’, ‘Elongate’, ‘Overlong’. The new species belongs to the ‘Elongate group’, which presents a wide variation in body length (597–4500 μm). The new species, Paramonostomum caeci from Australia, Paramonostomum actitidis from the Caribbean and Paramonostomum alveoelongatum from Russia share the smallest range of body size in this group (<1130 μm). The new species more closely resembles P. actitidis but differs from it by cirrus-sac length, which is shorter in the new species (97–146 vs 280–430 μm in P. actitidis), and egg size which is larger in the new species (25–33 vs 18–20 μm in P. actitidis). Paramonostomum deseado n. sp. uses the limpet Nacella magellanica as both first and second intermediate hosts in which metacercariae encyst inside the redia. This is the first abbreviated cycle described for notocotylid species. Ribosomal RNA sequences provided for adults (ITS1, ITS2 and 28S) and metacercariae inside the rediae (ITS1) support the species identification and the correspondence among stages. Phylogenetic analysis based on 28S placed P. deseado n. sp. close to other Notocotylus spp. and Paramonostomum anatis. Molecular results demonstrate that the hosts involved in the life cycles and the habitat more than morphological differences are determining the phylogenetic relationships in members of Notocotylidae.
Turning Points: Has Ethnomusicology Lost Its Way?
Authors: McLean Mervyn 
Published: August 2022

As some readers may know, I have recently published a book entitled Pioneers of Ethnomusicology. In it I try to answer the questionsWhat were the events that led to the emergence of ethnomusicology? Who were the prime movers? What motivated them? What influences were brought to bear on them, and what were the consequences? (McLean 2006: 11)
CORRECTING PTOLEMY AND ARISTOTLE: IBN AL-ṢALĀḤ ON MISTAKES IN THE ALMAGEST, ON THE HEAVENS, AND POSTERIOR ANALYTICS
Authors: Hullmeine Paul 
Published: August 2022

AbstractThe polymath Ibn al-Ṣalāḥ (d. 1154 CE) is known for a number of comparatively small treatises on specific aspects of ancient Greek mathematical and philosophical works. He devotes many of his works to greater or smaller errors that he found in the works by Euclid, Ptolemy, and Aristotle. The aim of the present paper, which focuses on three treatises on Ptolemy and Aristotle, is to describe Ibn al-Ṣalāḥ’s method and aim in these works. I argue that his treatises on the Almagest, On the Heavens, and Posterior Analytics follow a similar structure and that there is much value for modern research resulting from the bibliographical details provided by Ibn al-Ṣalāḥ. To give but just one example, Ibn al-Ṣalāḥ attests to the existence of a so far unknown Arabic translation of Aristotle's Posterior Analytics. In this way, this paper is the first to establish Ibn al-Ṣalāḥ’s research profile: his works tell us which sources were available to scholars active in Baghdad and Damascus in the 12th century CE and how he tried to resolve contradictions from the different versions of authoritative texts. Thus, this paper enhances our knowledge of the Graeco-Arabic transmission of scientific and philosophical texts.
How taxes impact the choice between an annuity and the lump sum at retirement
Authors: Bütler Monika , Ramsden Alma 
Published: August 2022

AbstractWe analyze how taxes affect the choice between a life-long annuity and a one-off lump sum payment, the so-called annuitization decision. Using administrative data from a large Swiss pension fund, we impute taxes for the lump sum and the life-long annuity option. We show that taxes can explain a significant part of the variation in annuity rates. Exploiting kinks in the tax schedule of the one-off lump sum, we further find evidence for tax optimization strategies. Our findings suggest that individuals react strongly to tax incentives when making retirement choices.
Why do legislators rebel on trade agreements? The effect of constituencies’ economic interests
Authors: Stiller Yannick 
Published: August 2022

AbstractMost trade agreements are ratified with overwhelming support by legislators throughout the world. This lack of opposition is surprising given the strong distributional consequences of trade and the expectation of conventional political economy theory that parliamentary votes on trade policy should be closely contested between winners and losers of globalization. To analyze the driving forces behind legislators’ voting behavior while avoiding the obscuring effect of party discipline, I analyze under which circumstances legislators decide to rebel against their party’s position when voting on the ratification of trade agreements. I put forward two hypotheses: First, rebellions are more likely when the trade agreement is with a larger trading partner and when the liberalization through the agreement is more comprehensive. Second, legislators will rebel when their party’s position does not align with their constituency’s economic interests. These hypotheses are supported by a series of multinomial regression analyses based on an original dataset comprising votes of several thousand legislators from multiple countries on the ratification of trade agreements.
Earth's Isostatic and Dynamic Topography—A Critical Perspective
Authors: Forte Alessandro M. , Rowley David B. 
Published: August 2022

AbstractEarth's topography arises from the linear superposition of isostatic and dynamic contributions. The isostatic contribution reflects the distribution of thickness and density of the crust overlying a static, non‐convecting mantle. We argue that isostatic topography should be limited to the crust, thereby delimiting all sources for dynamic topography below the Moho. Dynamic topography is the component of the topography produced by normal stresses acting on the Moho that deflect the isostatic topography away from crustal isostatic equilibrium largely as a consequence of mantle flow dynamics. These normal stresses arise from pressure variations and vertical gradients of the radial flow in the convecting mantle. The best estimate of dynamic topography is from the residual topography, which is the difference between observed topography and crustal isostatic topography. Dynamic and residual topography are the same. It is clear that thermal anomalies horizontally advected by plate motions would not exist if the mantle were not convecting, therefore their contribution to topography is inherently dynamic in origin. The global integral of dynamic topography that encompasses all non‐crustal buoyancy sources is demonstrated to be equal to zero. It follows that mantle convection cannot change the mean radius or mean elevation of the Earth. Since changes in ocean basin volume driven by changes in mean depth of the oceans are inherently part of dynamic topography, thereby requiring that continental elevations must also change, such that the global integral of these perturbations must also be equal to zero. This constraint has important implications for global long‐term sea level and the stratigraphic record, among other features of the Earth system impacted by changes in Earth's dynamic topography.
Identifying Causal Interactions Between Groundwater and Streamflow Using Convergent Cross‐Mapping
Authors: Bonotto Giancarlo , Peterson Tim J. , Fowler Keirnan , Western Andrew W. 
Published: August 2022

AbstractGroundwater (GW) is commonly conceptualized as causally linked to streamflow (SF). However, confirming where and how it occurs is challenging given the expense of experimental field monitoring. Therefore, hydrological modeling and water management often rely on expert knowledge to draw causality between SF and GW. This paper investigates the potential of convergent cross‐mapping (CCM) to identify causal interactions between SF and GW head. Widely used in ecology, CCM is a nonparametric method to identify causality in nonlinear dynamic systems. To apply CCM between variables the only required inputs are time‐series data (stream gauge and bore), so it may be an attractive alternative or complement to expensive field‐based studies of causality. Three upland catchments across different hydrogeologic settings and climatic conditions in Victoria, Australia, are adopted as case studies. The outputs of the method seem to largely agree with a priori perceptual understanding of the study areas and offered additional insights about hydrological processes. For instance, it suggested weaker SF‐GW interactions during and after the Millennium Drought than in the previous wet periods. However, we show that CCM limitations around seasonality, data sampling frequency, and long‐term trends could impact the variability and significance of causal links. Hence, care must be taken while physically interpreting the causal links suggested by CCM. Overall, this study shows that CCM can provide valuable causal information from common hydrological time‐series, which is relevant to a wide range of applications, but it should be used and interpreted with care and future research is needed.
Clumped‐Isotope Constraint on Upper‐Tropospheric Cooling During the Last Glacial Maximum
Authors: Banerjee Asmita , Yeung Laurence Y. , Murray Lee T. , Tie Xin , Tierney Jessica E. , Legrande Allegra N. 
Published: August 2022

AbstractIce cores and other paleotemperature proxies, together with general circulation models, have provided information on past surface temperatures and the atmosphere's composition in different climates. Little is known, however, about past temperatures at high altitudes, which play a crucial role in Earth's radiative energy budget. Paleoclimate records at high‐altitude sites are sparse, and the few that are available show poor agreement with climate model predictions. These disagreements could be due to insufficient spatial coverage, spatiotemporal biases, or model physics; new records that can mitigate or avoid these uncertainties are needed. Here, we constrain the change in upper‐tropospheric temperature at the global scale during the Last Glacial Maximum (LGM) using the clumped‐isotope composition of molecular oxygen trapped in polar ice cores. Aided by global three‐dimensional chemical transport modeling, we exploit the intrinsic temperature sensitivity of the clumped‐isotope composition of atmospheric oxygen to infer that the upper troposphere (effective mean altitude 10–11 km) was 6–9°C cooler during the LGM than during the late preindustrial Holocene. A complementary energy balance approach supports a minor or negligible steepening of atmospheric lapse rates during the LGM, which is consistent with a range of climate model simulations. Proxy‐model disagreements with other high‐altitude records may stem from inaccuracies in regional hydroclimate simulation, possibly related to land‐atmosphere feedbacks.
Locally Resolved Stress‐State in Samples During Experimental Deformation: Insights Into the Effect of Stress on Mineral Reactions
Authors: Cionoiu S. , Moulas E. , Stünitz H. , Tajčmanová L. 
Published: August 2022

AbstractUnderstanding conditions in the Earth's interior requires data derived from laboratory experiments. Such experiments provide important insights into the conditions under which mineral reactions take place as well as processes that control the localization of deformation in the deep Earth. We performed Griggs‐type general shear experiments in combination with numerical models, based on continuum mechanics, to quantify the effect of evolving sample geometry of the experimental assembly. The investigated system is constituted by CaCO3 and the experimental conditions are near the calcite‐aragonite phase transition. All experimental samples show a heterogeneous distribution of the two CaCO3 polymorphs after deformation. This distribution is interpreted to result from local stress variations. These variations are in agreement with the observed phase‐transition patterns and grain‐size gradients across the experimental sample. The comparison of the mechanical models with the sample provides insights into the distribution of local mechanical parameters during deformation. Our results show that, despite the use of homogeneous sample material (here calcite), stress variations develop due to the experimental geometry. The comparison of experiments and numerical models indicates that aragonite formation is primarily controlled by the spatial distribution of mechanical parameters. Furthermore, we monitor the maximum pressure and σ1 that is experienced in every part of our model domain for a given amount of time. We document that local pressure (mean stress) values are responsible for the transformation. Therefore, if the role of stress as a thermodynamic potential is investigated in similar experiments, an accurate description of the state of stress is required.
The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights
Authors: Xiang Qian , Zhao Yongzhao , Lin Jialiang , Jiang Shuai , Li Weishi 
Published: August 2022

AbstractIntervertebral disc degeneration (IDD) is a common degenerative musculoskeletal disorder and is recognized as a major contributor to discogenic lower back pain. However, the molecular mechanisms underlying IDD remain unclear, and therapeutic strategies for IDD are currently limited. Oxidative stress plays pivotal roles in the pathogenesis and progression of many age-related diseases in humans, including IDD. Nuclear factor E2-related factor 2 (Nrf2) is a master antioxidant transcription factor that protects cells against oxidative stress damage. Nrf2 is negatively modulated by Kelch-like ECH-associated protein 1 (Keap1) and exerts important effects on IDD progression. Accumulating evidence has revealed that Nrf2 can facilitate the transcription of downstream antioxidant genes in disc cells by binding to antioxidant response elements (AREs) in promoter regions, including heme oxygenase-1 (HO-1), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and NADPH quinone dehydrogenase 1 (NQO1). The Nrf2 antioxidant defense system regulates cell apoptosis, senescence, extracellular matrix (ECM) metabolism, the inflammatory response of the nucleus pulposus (NP), and calcification of the cartilaginous endplates (EP) in IDD. In this review, we aim to discuss the current knowledge on the roles of Nrf2 in IDD systematically.
m6A RNA methylation-mediated NDUFA4 promotes cell proliferation and metabolism in gastric cancer
Authors: Xu Weihong , Lai Yanan , Pan Yunqi , Tan Meiyu , Ma Yanyun , Sheng Huiming , Wang Jiucun 
Published: August 2022

AbstractGastric cancer (GC) is a malignancy with poor prognosis. NDUFA4 is reported to correlate with the progression of GC. However, its underlying mechanism in GC is unknown. Our study was to reveal the pathogenic mechanism of NDUFA4 in GC. NDUFA4 expression was explored in single-cell and bulk RNA-seq data as well as GC tissue microarray. Mitochondrial respiration and glycolysis were estimated by oxygen consumption rate and extracellular acidification rate, respectively. The interaction between NDUFA4 and METTL3 was validated by RNA immunoprecipitation. Flow cytometry was used to estimate cell cycle, apoptosis and mitochondrial activities. NDUFA4 was highly expressed in GC and its high expression indicated a poor prognosis. The knockdown of NDUFA4 could reduce cell proliferation and inhibit tumor growth. Meanwhile, NDUFA4 could promote glycolytic and oxidative metabolism in GC cells, whereas the inhibition of glycolysis suppressed the proliferation and tumor growth of GC. Besides, NDUFA4 inhibited ROS level and promoted MMP level in GC cells, whereas the inhibition of mitochondrial fission could reverse NDUFA4-induced glycolytic and oxidative metabolism and tumor growth of GC. Additionally, METTL3 could increase the m6A level of NDUFA4 mRNA via the m6A reader IGF2BP1 to promote NDUFA4 expression in GC cells. Our study revealed that NDUFA4 was increased by m6A methylation and could promote GC development via enhancing cell glycolysis and mitochondrial fission. NDUFA4 was a potential target for GC treatment.
Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats
Authors: Langer Henning T. , Mossakowski Agata A. , Sule Rasheed , Gomes Aldrin , Baar Keith 
Published: August 2022

AbstractThe tumor suppressor p53 is thought to play a key role in the maintenance of cell size and homeostasis, but relatively little is known about its role in skeletal muscle. Based on its ability to suppress cell growth, we hypothesized that inhibiting the function of wild-type p53 through the overexpression of a dominant-negative p53 mutant (DDp53) could result in muscle fiber hypertrophy. To test this hypothesis, we electroporated adult rat tibialis anterior muscles with DDp53 and collected the tissue three weeks later. We confirmed successful overexpression of DDp53 on a histological and biochemical level and found pronounced changes to muscle architecture, metabolism, and molecular signaling. Muscle mass, fiber cross-sectional area, and fiber diameter significantly decreased with DDp53 overexpression. We found histopathological changes in DDp53 transfected muscle which were accompanied by increased levels of proteins that are associated with membrane damage and repair. In addition, DDp53 decreased oxidative phosphorylation complex I and V protein levels, and despite its negative effects on muscle mass and fiber size, caused an increase in muscle protein synthesis as assessed via the SUnSET technique. Interestingly, the increase in muscle protein synthesis was concomitant with a decrease in phospho-S6K1 (Thr389). Furthermore, the muscle wasting in the DDp53 electroporated leg was accompanied by a decrease in global protein ubiquitination and an increase in proteasome activity. In conclusion, overexpression of a dominant-negative p53 mutant in skeletal muscle results in decreased muscle mass, myofiber size, histological muscle damage, a metabolic phenotype, and perturbed homeostasis between muscle protein synthesis and degradation.
Global crotonylome reveals hypoxia-mediated lamin A crotonylation regulated by HDAC6 in liver cancer
Authors: Zhang Dan , Tang Jing , Xu Yunhong , Huang Xiaoju , Wang Yilin , Jin Xin , Wu Gang , Liu Pian 
Published: August 2022

AbstractLysine crotonylation is a recently discovered post-translation modification involved in transcription regulation, cell signal transduction, and other processes. Scientists have identified several crotonylases and decrotonylases of histones, including P300/CBP, HDACs, and SIRTs. However, the regulation of non-histone protein crotonylation remains unclear. In the current study, we verified that crotonylation was upregulated in hypoxia and promoted liver cancer cell growth. We performed TMT-labeled quantitative lysine crotonylome analysis in 12 pairs of hepatocellular carcinoma and adjacent liver tissue and identified 3,793 lysine crotonylation sites in 1,428 proteins. We showed that crotonylation of lamin A at the site of K265/270 maintains its subcellular position, promotes liver cancer cell proliferation, and prevents cellular senescence. Our data indicate that HDAC6 is the decrotonylase of lamin A and downregulated in response to hypoxia, resulting in lamin A K265/270cr. Taken together, our study reveals the lamin A crotonylation in liver cancer progression and fills the research gap in non-histone protein crotonylation function.
Trends in COVID-19 hospital outcomes in England before and after vaccine introduction, a cohort study
Authors: Kirwan Peter D. , Charlett Andre , Birrell Paul , Elgohari Suzanne , Hope Russell , Mandal Sema , De Angelis Daniela , Presanis Anne M. 
Published: August 2022

AbstractWidespread vaccination campaigns have changed the landscape for COVID-19, vastly altering symptoms and reducing morbidity and mortality. We estimate trends in mortality by month of admission and vaccination status among those hospitalised with COVID-19 in England between March 2020 to September 2021, controlling for demographic factors and hospital load. Among 259,727 hospitalised COVID-19 cases, 51,948 (20.0%) experienced mortality in hospital. Hospitalised fatality risk ranged from 40.3% (95% confidence interval 39.4–41.3%) in March 2020 to 8.1% (7.2–9.0%) in June 2021. Older individuals and those with multiple co-morbidities were more likely to die or else experienced longer stays prior to discharge. Compared to unvaccinated people, the hazard of hospitalised mortality was 0.71 (0.67–0.77) with a first vaccine dose, and 0.56 (0.52–0.61) with a second vaccine dose. Compared to hospital load at 0–20% of the busiest week, the hazard of hospitalised mortality during periods of peak load (90–100%), was 1.23 (1.12–1.34). The prognosis for people hospitalised with COVID-19 in England has varied substantially throughout the pandemic and according to case-mix, vaccination, and hospital load. Our estimates provide an indication for demands on hospital resources, and the relationship between hospital burden and outcomes.
Planktonic foraminifera organic carbon isotopes as archives of upper ocean carbon cycling
Authors: Hoogakker Babette A. A. , Anderson Caroline , Paoloni Tommaso , Stott Andrew , Grant Helen , Keenan Patrick , Mahaffey Claire , Blackbird Sabena , McClymont Erin L. , Rickaby Ros , Poulton Alex , Peck Victoria L. 
Published: August 2022

AbstractThe carbon cycle is a key regulator of Earth’s climate. On geological time-scales, our understanding of particulate organic matter (POM), an important upper ocean carbon pool that fuels ecosystems and an integrated part of the carbon cycle, is limited. Here we investigate the relationship of planktonic foraminifera-bound organic carbon isotopes (δ13Corg-pforam) with δ13Corg of POM (δ13Corg-POM). We compare δ13Corg-pforam of several planktonic foraminifera species from plankton nets and recent sediment cores with δ13Corg-POM on a N-S Atlantic Ocean transect. Our results indicate that δ13Corg-pforam of planktonic foraminifera are remarkably similar to δ13Corg-POM. Application of our method on a glacial sample furthermore provided a δ13Corg-pforam value similar to glacial δ13Corg-POM predictions. We thus show that δ13Corg-pforam is a promising proxy to reconstruct environmental conditions in the upper ocean, providing a route to isolate past variations in δ13Corg-POM and better understanding of the evolution of the carbon cycle over geological time-scales.