bluuebunny/crossref_metadata_2025_split huggingface dataset:
No fuss please! I’m deafblind: a personal point of view and some friendly suggestions
Authors: Wilson-Hinds Roger 
Published: April 2022

Purpose
This paper aims to offer practical suggestions as to factors needing consideration when meeting, interacting with or assessing the needs of an older person living with acquired deafblindness.

Design/methodology/approach
The paper’s author draws on his personal experience of living with acquired deafblindness to offer practical suggestions.

Findings
This paper offers an experiential definition of acquired deafblindness, before providing practical suggestions related to engaging with deafblind people, distinguishing between acquired deafblindness and cognitive decline, and assessing hearing and sight levels.

Originality/value
There is a paucity of literature on the lived experience of older people living with acquired deafblindness. This paper offers both a unique insight into this experience combined with practical suggestions for those in contact with older deafblind people.
Status Epilepticus Australasian Registry for Children: A pilot prospective, observational, cohort study of paediatric status epilepticus
Authors: Furyk Jeremy S , George Shane , Phillips Natalie , Emeto Theophilus I , Watt Kerrianne , O'Brien Sharon , Riney Kate , Wilson Catherine , Hearps Stephen JC , Borland Meredith L , Dalziel Stuart R , Babl Franz E ,   on behalf of the Paediatric Research in Emergency Departments International Collaborative (PREDICT)
Published: April 2022

AbstractObjectivePaediatric status epilepticus (SE) has potential for long‐term sequelae. Existing data demonstrate delays to aspects of care. The objective of the present study was to examine the feasibility of collecting data on children with paediatric SE and describe current management strategies in pre‐hospital and in‐hospital settings.MethodsA pilot, prospective, observational cohort study of children 4 weeks to 16 years of age with SE, in four EDs in Australia. Clinical details including medications administered, duration of seizure and short‐term outcomes were collected. Follow up occurred by telephone at 1 month.ResultsWe enrolled 167 children with SE. Mean age was 5.4 years (standard deviation [SD] 4.1), and 81 (49%) male. Median seizure duration was 10 min (interquartile range 7–30). Midazolam was the first medication administered in 87/100 (87%) instances, mean dose of 0.21 mg/kg (SD 0.13). The dose of midazolam was adequate in 30 (35%), high (>0.2 mg/kg) in 44 (51%) and low (<0.1 mg/kg) in 13 (15%). For second‐line agents, levetiracetam was administered on 33/55 (60%) occasions, whereas phenytoin and phenobarbitone were administered on 11/55 (20%) occasions each. Mean dose of levetiracetam was 26.4 mg/kg (SD 13.5). One hundred and four (62%) patients were admitted to hospital, with 13 (8%) admitted to ICU and seven (4%) intubated.ConclusionIn children presenting with SE in Australia medical management differed from previous reports, with midazolam as the preferred benzodiazepine, and levetiracetam replacing phenytoin as the preferred second‐line agent. This pilot study indicates the feasibility of a paediatric SE registry and its utility to understand and optimise practice.
Long‐term quantification of leaf‐cutting ant damage in willow forestations in the lower delta of the Paraná River, Argentina
Authors: Jiménez Nadia Lis , Farji‐Brener Alejandro Gustavo , Calcaterra Luis Alberto 
Published: April 2022

Abstract
Leaf‐cutting ants are major pests of Neotropics forest plantations. The lower delta of the Paraná River contains the main Argentine Salicaceae production, strongly attacked by Acromyrmex lundii and Acromyrmex ambiguus. Nevertheless, there is no damage quantification in willow plantations attributed to leaf‐cutting ant species.
In an area without leaf‐cutting ant control, we installed 15 blocks with eight willow stakes each: four clones × two treatments; with and without leaf‐cutting ant exclusion. We used two traditional (Americano, Nigra 4) and two new (Géminis, Yaguareté) commercial clones. During 2014–2018, we measured the damaged foliage, height and diameter of each tree.
Foliage was damaged intensely during the first 2 years. After 1537 days, the loss in height and diameter was greater in Americano (70%), followed by Géminis (50%–60%), Yaguareté (40%–50%) and Nigra 4 (45%–40%). Stake survival with exclusion was greater (>80%) than stakes without exclusion (<50%). Total loss of wood volume was 93% for Americano, followed by Géminis (77%), Yaguareté (66%) and Nigra 4 (51%).
Although the new clones were heavily attacked, they produced two to three times more wood volume than Americano; replacing Americano with the new clones would help to reduce leaf‐cutting ants impact on plantations and pesticides released into the environment.
Percutaneous coronary intervention in insulin‐treated diabetic patients: A meta‐analysis
Authors: Ge Ying , He Daikun , Shao Yiru , Wang Lina , Yan Wei 
Published: April 2022

AbstractBackgroundThis meta‐analysis of randomized controlled trials (RCTs) compared long‐term adverse clinical outcomes of percutaneous coronary intervention (PCI) in insulin‐treated diabetes mellitus (ITDM) and non‐ITDM patients.MethodsThis is a meta‐analysis study. The PubMed and Embase databases were searched for articles on long‐term adverse clinical outcomes of PCI in ITDM and non‐ITDM patients. The risk ratios (RR) and 95% confidence intervals (CI) were calculated.ResultsA total of 11 related RCTs involving 8853 DM patients were included. Compared with non‐ITDM patients, ITDM patients had significantly higher all‐cause mortality (ACM) (RR = 1.52, 95% CI: 1.25–1.85, pheterogeneity = .689, I2 = 0%), major adverse cardiac and cerebrovascular events (MACCE) (RR = 1.35, 95% CI: 1.18–1.55, pheterogeneity = .57, I2 = 0%), myocardial infarction (MI) (RR = 1.41, 95% CI: 1.16–1.72, pheterogeneity = .962, I2 = 0%), and stent thrombosis (ST) (RR = 1.75, 95% CI: 1.23–2.48, pheterogeneity = .159, I2 = 32.4%). No significant difference was found in the target lesion revascularization (TLR) and target vessel revascularization (TVR) between the ITDM and non‐ITDM groups.ConclusionsThe results showed that ITDM patients had significantly higher ACM, MACCE, MI, and ST, compared with non‐ITDM patients.
Incidence and risk factors of deep vein thrombosis after extracorporeal life support
Authors: van Minnen Olivier , van den Bergh Walter M. , Droogh Joep M. , Koehorst Lisette , Lagrand Wim K. , Raasveld S. Jorinde , Oude Lansink‐Hartgring Annemieke , Terpstra Aart , Smit Jasper M. , Tuinman Pieter R. , Vlaar Alexander P. J. 
Published: April 2022

AbstractBackgroundDeep vein thrombosis (DVT) after decannulation of extracorporeal life support (ECLS) is not uncommon. Moreover, the impact of anticoagulation and potential risk factors is unclear. Furthermore, it is unclear if cannula‐associated DVT is more common in ECLS patients compared to critically ill patients without ECLS.MethodsAll adult patients who were successfully weaned from ECLS and were screened for DVT following decannulation were included in this observational cohort study. The incidence of post‐ECLS‐DVT was assessed and the cannula‐associated DVT rate was compared with that of patients without ECLS after central venous catheter (CVC) removal. The correlation between the level of anticoagulation, risk factors, and post‐ECLS‐DVT was determined.ResultsWe included 30 ECLS patients and 53 non‐ECLS patients. DVT was found in 15 patients (50%) of which 10 patients had a DVT in a cannulated vein. No correlation between the level of anticoagulation and DVT was found. V‐V ECLS mode was the only independent risk factor for post‐ECLS‐DVT (OR 5.5; 95%CI 1.16–26.41). We found no difference between the ECLS and non‐ECLS cohorts regarding cannula‐associated DVT rate (33% vs. 32%).ConclusionPost‐ECLS‐DVT is a common finding that occurs in half of all patients supported with ECLS. The incidence of cannula‐associated DVT was equal to CVC‐associated DVT in critically ill patients without ECLS. V‐V ECLS was an independent risk factor for post‐ECLS‐DVT.
R&D subsidies in a duopoly market with outsourcing to the rival firm
Authors: Fanti Luciano , Buccella Domenico , Gori Luca 
Published: April 2022

AbstractThis paper investigates the effects of a public uniform R&D subsidy policy in a downstream duopoly market in which a nonintegrated firm, which faces a lower marginal cost, outsources inputs from its vertically integrated rival. The findings show that, in this market structure, such a policy has relevant effects largely differentiated between downstream competitors, as it can significantly modify the relative market shares and profitability of competing firms. Unlike the standard Cournot setting augmented with R&D, results show that the subsidy policy can have different (counterintuitive) effects on R&D investments, output, and profits of the vertically integrated producer and the vertically separated firm, which hold in both cases of exogenous and endogenous (optimal) subsidy. Our findings offer some testable implications and suggest that a subsidy policy in a market with outsourcing to a rival should also consider the different effects of this approach on competitors.
Government, trade and comparative advantage, revisited
Authors: Tawada Makoto , Suga Nobuhito , Yanase Akihiko 
Published: April 2022

AbstractThis study conducts a detailed analysis of the production possibility frontier (PPF) in an economy with two goods, each produced using labour and a specific factor as inputs, and public infrastructure, which has positive externalities on the production of each good. We show that if the elasticity of a specific factor input into production is sufficiently small, the PPF has a concave–convex–concave shape. Although our model is similar to the one developed in 1992 by Richard H. Clarida and Ronald Findlay, this possibility was overlooked in their analysis and it can generate trade patterns that are against the law of comparative advantage. Nevertheless, trade is always gainful and, as in the existing studies, trade openness increases the provision of public infrastructure in a country exporting goods whose productivity is highly dependent on infrastructure. We also examine the relationship between factor endowments and comparative advantage.
The effects of long‐term continuous positive airway pressure on apnea–hypopnea index change following short‐term that withdrawal in patients with obstructive sleep apnea
Authors: Wang Longlong , Pan Minxia , Ou Qiong 
Published: April 2022

AbstractThe effect of long‐term continuous positive airway pressure (CPAP) treatment on apnea–hypopnea index (AHI) after CPAP withdrawal remains unclear, especially in obstructive sleep apnea (OSA) patients screened from the population. To examine that, 1241 civil servants who participated in the annual physical examination were screened for OSA between September and December 2017. Screened OSA firstly underwent 1‐week CPAP adherence assessment. Then, patients with good CPAP adherence would be freely provided CPAP to continued treatment. All OSA patients were followed for 2 years. At study end, all OSA patients underwent home sleep testing (HST) again within 1 week of CPAP withdrawal. The effect of 2‐year CPAP treatment on OSA severity was investigated by using linear regression and multinominal logistic regression. In total, 103 OSA patients were screened, including 41 cases (39.8%) in CPAP treatment group and 62 cases (60.2%) in non‐CPAP treatment group. At 2‐year follow‐up, compared with baseline, in CPAP treatment group, following CPAP withdrawal, a significant decrease in AHI was observed in patients with severe OSA (P = 0.014); in non‐CPAP treatment group, a significant increase in AHI was observed in patients with moderate OSA (P = 0.028). After adjustment for confounding factors, multivariate linear regression showed that △AHI was negatively associated with CPAP treatment (β = −4.930, 95% confidence interval [CI] [−9.361, −0.500], P = 0.030). Multinominal logistic regression showed that the AHI of patients not treated with CPAP tended to be unchanged or worsened with the AHI improvement group as a reference (OR [odds ration] [95% CI], 4.555 [1.307, 15.875], P = 0.017; 6.536 [1.171, 36.478], P = 0.032). In conclusion, active OSA screening and long‐term CPAP intervention may improve the severity of severe OSA patients following short‐term CPAP withdrawal in the general population.
The trajectory of computer science education policy in Ireland: A document analysis narrative
Authors: Connolly Cornelia , Byrne Jake Rowan , Oldham Elizabeth 
Published: April 2022

AbstractThe launch of a Computer Science curriculum specification in upper secondary schools in Ireland in 2018 was a landmark and a historic development in Irish education. Addressing the historical policy decisions adopted towards establishing the specification, this paper presents an analysis of developments from the 1970s as revealed in key policies and other documents. Positioning the policy change within the context of influences, context of policy text production and within the context of practices, the paper presents an overview of the Irish Computer Science specification. Alongside the background to the evolution in computer science education over the period, the article takes into account the national and cultural contexts and narrates the journey travelled to arrive at this pivotal position. Developments in a global context are presented in comparison with curricula in other countries and some similarities and differences identified. The article uncovers consequences of the specification for the national curriculum, key skills integration and computer science teacher preparation. The article provides an important analysis of the policy trajectory of computer science in Ireland based on a visibly relevant corpus of documents tracing the different stages of this policy and comparing it to similar experiences implemented in other European countries.
Role modeling or reciprocity? Dyadic intergenerational transfer analysis of efficacy and support
Authors: Liu Rong‐Kou 
Published: April 2022

AbstractObjectiveThis study examined intergenerational transmission of family members' mutual support and family efficacy beliefs.BackgroundWhile social exchange theory assumes that reciprocity guides intergenerational transfers, social cognitive theory posits that family efficacy beliefs and behaviors may be acquired from vicarious experiences. This study examined these perspectives and considered cultural context and value orientations.MethodA total of 1061 parent–adult child dyads were drawn from 2018 data of the Panel Study of Family Dynamics (Taiwan). The actor–partner interdependence model (APIM) and path modeling were used for statistical analysis.ResultsAfter controlling for demographic effects, parents' parental efficacy, rather than filial efficacy, was the key contributor to adult children's filial efficacy. No significant association was observed between adult children's and parents' upward support. Considering support type, emotional connection and housework help showed strong positive intergenerational relations. Financial provisions mainly related to filial norms.ConclusionRole modeling had a weak effect; the results are primarily consistent with the reciprocal perspective on intergenerational relations.ImplicationsAlthough family ethics still deeply pervade Taiwanese society, parent–adult child mutual engagement, in addition to resources and demands, seems crucial for perceived family efficacy and mutual support. This study incorporates psychological factors to further explain the relationship between family efficacy and support.
Inhibition of lipopolysaccharide‐induced inflammatory responses by 1′‐acetoxychavicol acetate
Authors: Ong Guang Han , Ori Daisuke , Kawasaki Takumi , Kawai Taro 
Published: April 2022

AbstractLipopolysaccharide on gram negative bacteria can be detected by Toll‐like receptor 4 (TLR4) to elicit a series of innate immune responses, leading to inflammation to eliminate the targeted pathogen. However, dysregulation in the responses results in excessive inflammation. The 1′‐acetoxychavicol acetate (ACA) is a bioactive compound originated from Alpinia species known to have anti‐inflammatory and apoptosis‐inducing properties. Here, we found that ACA inhibits lipopolysaccharide‐induced expression and production of proinflammatory cytokines such as interleukin 6 and TNFα by macrophages. ACA suppresses the activation of NF‐κB and MAP kinases in TLR4 signaling. Moreover, ACA also inhibits TLR4‐mediated induction of type I interferon by suppressing IRF3 activation. In lipopolysaccharide‐challenged mice, ACA treatment successfully increased the survival of mice and alleviated inflammation in the lung. Thus, ACA is a potential anti‐inflammatory agent to regulate excessive inflammation.
CTLA4‐Ig prevents development of neutralizing antibody formation after continuous treatment with human FVIII in HA rats
Authors: Øvlisen Gabi Overgaard , Thygesen Peter , Weldingh Karin Nana , Bloem Esther , Skov Søren , Almholt Kasper , Lövgren Karin Maria , Ley Carsten Dan , Holm Thomas Lindebo 
Published: April 2022

AbstractIntroductionImmunogenicity causing development of anti‐drug antibodies (ADAs) are major challenges in the treatment of haemophilia, as well as other diseases where proteins are used for treatment. Furthermore, it is a complication for preclinical testing of such therapies in animal models.AimTo investigate if the immunosuppressive drug CTLA4 immunoglobulin (CTLA4‐Ig) can induce tolerance in haemophilia A (HA) rats receiving recombinant human coagulation factor VIII (rhFVIII) treatment.MethodsTwo different prophylactic rhFVIII compounds were given intravenously to HA rats for 4 weeks. Both rhFVIII compounds were co‐administered with commercially available CTLA4‐Ig or human IgG subclass 4 (hIgG4) as control, and blood samples were collected. To functionally test if pharmacological efficacy was retained, rats were subjected to a bleeding experiment under anaesthesia at end of study.ResultsThe mean inhibitory level after 4 weeks in rats receiving rhFVIII and hIgG4 was 85.7 BU for octocog alfa and 37.4 BU for rurioctocog alfa pegol. In contrast, co‐administration with CTLA4‐Ig during rhFVIII therapy prevented the formation of ADAs (both binding and inhibitory) in 14/14 rats receiving octocog alfa and in 7/7 rats receiving rurioctocog alfa pegol. Moreover, we were able to show that the pharmacological efficacy of rhFVIII was preserved.ConclusionIn a rat model with spontaneous bleeding, co‐administration of CTLA4‐Ig with rhFVIII prevented antibody formation. No FVIII antibodies were detected, demonstrating that CTLA4‐Ig co‐administration can be applicable as a method to prevent immunogenicity, when evaluating human proteins in preclinical systems permitting continuous pharmacokinetic and pharmacodynamic assessment.
Most bothersome symptoms in patients with migraine: A hospital‐based study in Taiwan
Authors: Tu Yi‐Hsien , Wang Yen‐Feng , Yuan Hsiangkuo , Chen Shih‐Pin , Tzeng Yi‐Shiang , Chen Wei‐Ta , Lai Kuan‐Lin , Ling Yu‐Hsiang , Wang Shuu‐Jiun 
Published: April 2022

AbstractObjectiveTo investigate the distribution, clinical associations, and treatment responses for the most bothersome symptoms of migraine in a large sample of patients with migraine in Taiwan.BackgroundThe most bothersome symptom is recently recommended as a co‐primary endpoint in clinical trials of acute treatment of migraine. However, most clinical trials and observational studies have been conducted in the United States and Europe, with photophobia representing the most common most bothersome symptom.MethodsPatients who were newly diagnosed with migraine by headache specialists in Taipei Veterans General Hospital were recruited. All participants completed a questionnaire for headache profile, including the most bothersome symptom. Clinical associations of the most bothersome symptoms and response rates to previous acute treatments were analyzed.ResultsAmong the recruited 1188 patients with migraine (female 79.4%, mean age 39.0 ± 12.1 years) in this cross‐sectional study, nausea (n = 729/1188, 61.4%) was the most common symptom that was most bothersome, followed by phonophobia (n = 280/1188, 23.6%), and photophobia (n = 122/1188, 10.3%). The frequency ranking was the same regardless of sex and age. Compared to migraine without aura, migraine with aura was associated with photophobia (adjusted odds ratio [OR] = 2.97, 95% confidence interval [CI] 1.76–5.0, p < 0.001). Chronic migraine was associated with phonophobia (adjusted OR = 1.51, 95% CI 1.13–2.01, p = 0.005), but there was a lower chance for nausea (adjusted OR = 0.68, 95% CI 0.53–0.88, p = 0.004), as the most bothersome symptom. Patients with different most‐bothersome symptoms responded similarly to previous acute treatments, with an overall response rate of 52.2% (n = 550/1053).ConclusionPatients with migraine in Taiwan reported a distinct ranking of the most bothersome symptom. However, the response rates of the most bothersome symptom and headache were similar, which supports the most bothersome symptom as an outcome measure for acute treatment of migraine. Further studies recruiting different populations are required to investigate regional differences in most bothersome symptoms.
Anthocyanin‐rich fruit vinegar from Grewia and Cantaloupe fruit blends
Authors: Gaur Rudra Shalini , Singh Sunita , H. Harish , Bollinedi Haritha , Singh Kamalesh Narain , Nain Lata , Singh Surender , Awasthi Om Prakash 
Published: April 2022

SummaryGrewia is a tropical berry rich in anthocyanins and antioxidants but highly perishable in nature. In this study, desirable composite blend of overripe Grewia (Phalsa) berries and cantaloupe was sought for conversion to acetic acid. Composition of raw macerate, and the alcoholic and acetic ferments was analysed for sugars, alcohol and acetic acid. The primary alcohol yield varied significantly (5.75–99.44%) with blend composition. Vinegar from select blend attained 4.98% acidity with 138.57 mg mL−1 of phenols and high anthocyanins retention (74.77%). Gompertz model was used to fit the growth curves of S. cerevisiae and A. aceti (R2> 0.92) during fermentation. Presence of ethyl acetate, iso‐pentyl alcohols explained pleasant sweet fruity aroma of resulting vinegar. Thus, high quality functional red fruit vinegar can be obtained to prevent spoilage and utilise the functional potential of this delicate and nutritious berry.
First isolation of Flavobacterium psychrophilum from wild adult Great Lakes lake whitefish (Coregonus clupeaformis)
Authors: Harrison Courtney E. , Knupp Christopher K. , Brenden Travis O. , Ebener Mark P. , Loch Thomas P. 
Published: April 2022

AbstractLake whitefish (Coregonus clupeaformis; LWF) is an economically and ecologically valuable native species to the Great Lakes, but recent declines in their recruitment have generated significant concern about their future viability. Although studies have sought to identify factors contributing to declining recruitment, the potential role(s) of infectious diseases has not been thoroughly investigated. In 2018 and 2019, adult LWF were collected from Lakes Superior, Michigan, and Huron for clinical examination and bacteriological analyses. Herein, we describe the first isolation of Flavobacterium psychrophilum, aetiological agent of bacterial coldwater disease (BCWD) and rainbow trout fry syndrome (RTFS), from systemically infected adult LWF. Bacterial isolates were yellow‐orange, Gram‐negative, filamentous bacilli that were oxidase and catalase positive, and produced a flexirubin‐type pigment in 3% potassium hydroxide. Isolate identity was confirmed via F. psychrophilum‐specific PCR, and multilocus sequence typing revealed three new singleton sequence types (STs) that were distinct from all previously described F. psychrophilum STs. The prevalence of F. psychrophilum infections was 3.3, 1.7, and 0.0% in Lakes Superior, Michigan and Huron respectively. Findings illustrate the potential for F. psychrophilum to cause systemic infections in adult LWF and highlight the need for future studies to investigate the bacterium's potential role in declining LWF recruitment.