bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic effect of adipose stromal vascular fraction spheroids for partial bladder outlet obstruction induced underactive bladder
Authors: Liu Jingyu , Zhou Liuhua , Zhao Feng , Zhou Changcheng , Yang Tianli , Xu Zhongle , Wang Xinning , Xu Luwei , Xu Zheng , Ge Yuzheng , Wu Ran , Jia Ruipeng 
Published: February 2022

Abstract
Background
Underactive bladder (UAB) is a common clinical problem but related research is rarely explored. As there are currently no effective therapies, the administration of adipose stromal vascular fraction (ad-SVF) provides a new potential method to treat underactive bladder.

Methods
Male Sprague–Dawley rats were induced by partial bladder outlet obstruction (PBOO) for four weeks and randomly divided into three groups: rats treated with PBS (Sham group); rats administrated with ad-SVF (ad-SVF group) and rats performed with ad-SVF spheroids (ad-SVFsp group). After four weeks, urodynamic studies were performed to evaluate bladder functions and all rats were sacrificed for further studies.

Results
We observed that the bladder functions and symptoms of UAB were significantly improved in the ad-SVFsp group than that in the Sham group and ad-SVF group. Meanwhile, our data showed that ad-SVF spheroids could remarkably promote angiogenesis, suppress cell apoptosis and stimulate cell proliferation in bladder tissue than that in the other two groups. Moreover, ad-SVF spheroids increased the expression levels of bFGF, HGF and VEGF-A than ad-SVF. IVIS Spectrum small-animal in vivo imaging system revealed that ad-SVF spheroids could increase the retention rate of transplanted cells in bladder tissue.

Conclusions
Ad-SVF spheroids improved functions and symptoms of bladder induced by PBOO, which contributes to promote angiogenesis, suppress cell apoptosis and stimulate cell proliferation. Ad-SVF spheroids provide a potential treatment for the future patients with UAB.
Economic impact of powered stapler in video-assisted thoracic surgery lobectomy for lung Cancer in a Chinese tertiary hospital: a cost-minimization analysis
Authors: Cao Yang , Xiong Fang , Xia Xiaozhe , Gu Pengjuan , Wang Qinghong , Wu Aiping , Zhan Huan , Chen Wendong , Qian Zhaoxin 
Published: February 2022

Abstract
Background
To assess the economic impact of powered stapler use in video-assisted thoracic surgery (VATS) lobectomy for lung cancer in a Chinese tertiary care hospital.

Methods
This study identified 388 patients who received VATS lobectomy using the ECHELON powered stapler (n = 296) or the ECHELON manual stapler (n = 92) for lung cancer in a Chinese tertiary hospital. Multiple generalized linear regression analyses were conducted using data on hospital costs and patient characteristics to develop predictive equations for hospital costs in a cost-minimization analysis (CMA) model comparing hospital costs associated with the ECHELON powered stapler and the ECHELON manual stapler. CMA model was used to conduct scenario analysis to compare the ECHELON powered stapler with another manual stapler (Victor Medical).

Results
The multiple generalized linear regression analyses identified that using the ECHELON powered stapler in VATS lobectomy for lung cancer was associated with significantly lower drug costs than using the ECHELON manual stapler (coefficient − 0.256, 95% confidence interval: − 0.375 to − 0.139). The CMA model estimated that the ECHELON powered stapler could save hospital costs by ¥1653 when compared with the ECHELON manual stapler (¥65,531 vs. ¥67,184). The use of the ECHELON powered stapler also saved hospital costs by ¥4411 when compared with the Victor Medical manual stapler (¥65,531 vs. ¥69,942) in the scenario analysis.

Conclusions
Compared to the two manual staplers used for VATS lobectomy for lung cancer in a Chinese tertiary hospital, the ECHELON powered stapler had 100% probability to save total hospital costs under present prices of the three staplers according to the CMA.
Evaluating the effects of dance on motor outcomes, non-motor outcomes, and quality of life in people living with Parkinson’s: a feasibility study
Authors: Carapellotti Anna M. , Rodger Matthew , Doumas Michail 
Published: February 2022

AbstractBackgroundCommunity-based dance programs for people living with Parkinson’s have grown in popularity over the past two decades. Studies investigating these programs have demonstrated multidimensional benefits in motor, non-motor, and quality of life related outcomes, yet there is a need to focus on the feasibility of larger trials. The primary objective of this study was to assess the feasibility and acceptability of conducting a trial investigating dance and Parkinson’s in Northern Ireland. The secondary objectives were to conduct preliminary analyses of the classes’ effects and to assess the appropriateness of outcome measures for a randomized controlled trial.MethodsParticipants were recruited through the community, Parkinson’s UK, and university contacts to participate in a 12-week dance intervention inspired by the Dance for PD® model. Pre- and post-intervention, participants completed the following outcomes: MDS-UPDRS III, TUG, DT-TUG, Sensory Organization Test, MoCA, Trail Making Tests A&B, Digit Symbol Substitution Test, Digit Span, PDQ-39, FOG-Q, PHQ-9, FES-I, and an exit questionnaire (post-test only). Data were analyzed using paired samplesttests or Wilcoxon signed ranked test.ResultsTen people living with Parkinson’s participated. Running a larger trial was deemed infeasible in this setting due to recruitment issues; conversely, the dance intervention was accepted by participants with all but one completing the study. Functional mobility (TUG), symptoms of depression (PHQ-9), and bodily discomfort showed improvement. All other outcomes did not. The exit questionnaire revealed that the social aspect of classes was important, and improvements in mood or mental state were cited most frequently as perceived benefits. Outcome measures were feasible, with some changes suggested for future trials.ConclusionsThis study highlighted the infeasibility of running a larger trial using this design in this setting despite demonstrating the acceptability of implementing a dance program in Northern Ireland for people living with Parkinson’s. The results support existing evidence demonstrating that dance may improve functional mobility and symptoms of depression in people living with Parkinson’s, though the study design and small sample size prevent the generalizability of results. The findings also support the idea that dancing has the potential to support several aspects of physical, emotional, mental, and social health.
Reversible transition from ferrofluid drop to spikes due to an approaching magnet
Authors: Jain S. K. , Banerjee U. , Mandal C. , Sen A. K. 
Published: February 2022

Abstract
Remarkably, we experimentally evidenced normal field instability-driven reversible transition from ferrofluid droplet to spikes, when a sessile ferrofluid drop is exposed to a varying magnetic field gradient due to an approaching magnet, without flipping its direction of motion. We find the reversible transition is attributed to the critical magnetization of the ferrofluid and a characteristic wavelength that control normal-field instability. We extend the theory of magnetic instability by including non-uniformity in the magnetic field in all directions to predict the critical condition for transition, which is in good agreement with experiments. The spacing between spikes and spike height, and the number of spikes measured from experiments are in agreement with existing theory.
Fabry-Pérot interference in 2D low-density Rashba gas
Authors: Li Yuan-Qiao , Chen Xi-Rong , Luo Wei , Zhou Tao , Chen Wei 
Published: February 2022

Abstract
In mesoscopic electronic systems, the Fabry-Pérot (FP) oscillation is observed in various 1D devices. As for higher dimensions, numerous transverse channels usually lead to dephasing that quenches the overall oscillation of the conductance. Up to now, the FP oscillation in 2D electronic systems is only reported in graphene-based devices and very recently, the pn junctions of inverted InAs/GaSb double quantum well (Karalic M. et al., Phys. Rev. X, 10 (2020) 031007). In the latter, the band shape of a sombrero hat plays an essential role, which introduces a novel mechanism of electron-hole hybridization for the 2D FP oscillation. In this work, we propose that such a scenario can be generalized to the 2D planar junction composed of low-density Rashba gas, where the band bottom possesses sombrero hat shape as well. We show that the backscattering between the outer and inner Fermi circles dominates the FP interference and significantly suppresses the dephasing effect between different transverse channels, which leads to a visible oscillation of the tunneling conductance. In particular, the visibility of the oscillating pattern can be enhanced by applying interface barriers, which is in contrast to that in the InAs/GaSb double quantum well. Our results provide a promising way for the implementation of the FP oscillation in the 2D electron gas.
Exponentially generalized vortex
Authors: Lima F. C. E. , Almeida C. A. S. 
Published: February 2022

AbstractIn this work, we propose an exponentially generalized Abelian model. We investigated the presence of vortex structures in models coupled to Maxwell and Chern-Simons fields. We chose to investigate the dynamics of the complex scalar field in models coupled separately to the Maxwell term and the Chern-Simons term. For this, we analyze the Bogomol'nyi equations in both cases to describe the static field configurations. An interesting result appears when we note that scalar field solutions generate degenerate minimum energy configurations by a factor ofin Maxwell's case. On the other hand, in the Chern-Simons case, the solutions in this sector are degenerate by a factor of. Finally, we solve the Bogomol'nyi equations numerically and discuss our results.
Epitaxial-strain–dependent reorientation of oxygen octahedral tilting axis in manganite films
Authors: Zhang Wujun , Jin Feng , Zhang Xingchang , Tang Yuling , Xu Pan , Lin Nan , Wang Zuyong , Wu Wenbin , Ma Chao 
Published: February 2022

Abstract
As one of the most ubiquitous lattice distortions in complex transition metal oxides, oxygen octahedral rotation/tilting plays an important role in their physical properties. In this paper, we report the evolution of oxygen octahedral tilting in La2/3Ca1/3MnO3 films grown on NdGaO3 substrates with different orientations by using an aberration-corrected scanning transmission electron microscope. Different epitaxial strains depending on the substrate orientation lead to different orientation relationships between the films and substrates. Unlike conventional coherent growth, our experimental results demonstrate that the reorientation of the oxygen octahedral tilting axis, depending on epitaxial strains, would occur at the interface between the film and substrate for the (010)-oriented substrate or inside the film for the (1-12)-oriented substrate, as well supported by theoretical calculations via density functional theory method and electron energy loss spectroscopy measurements. Considering the universality of interfacial oxygen octahedral coupling in oxide heterostructures, these experimental findings offer great insights in understanding thickness- and orientation-dependent physical properties of thin films.
Are Married Women Really Wealthier Than Unmarried Women? Evidence From Japan
Authors: Niimi Yoko 
Published: February 2022

Abstract
Using microdata from the Japanese Panel Survey of Consumers, this article examines the relationship between marriage and wealth among women. By exploiting unique data on personal wealth, it also assesses whether the wealth effect of marriage differs depending on whether wealth is measured as household or personal wealth, an issue that very few studies have examined. When wealth is measured as equivalized household net worth, on the assumption that married couples share household resources equally, marriage is found to contribute to women's wealth holdings but only to their nonfinancial net worth; however, the results show signs that marriage also contributes to women's total net worth as marriage durations increase. By contrast, when wealth is measured as personal net worth based on the actual ownership of assets, marriage is found to be negatively and significantly associated with women's wealth holdings. These findings underscore the fact that Japanese women are potentially in a financially vulnerable position even after marriage, which is at least partly driven by married women's career disruptions arising from their family responsibilities.
Acute Exercise Regulates hTERT Gene Expression and Alternative Splicing in the hTERT-BAC Transgenic Mouse Model
Authors: SLUSHER AARON L. , KIM JEONGJIN JJ , RIBICK MARK , LUDLOW ANDREW T. 
Published: February 2022

ABSTRACT

Introduction
Aerobic exercise maintains telomere length through increased human telomerase reverse transcriptase (hTERT) expression and telomerase enzyme activity. The impact of acute exercise on hTERT alternative splicing (AS) is unknown.

Purpose
This study aimed to examine hTERT AS in response to acute treadmill running.

Methods
A bacterial artificial chromosome mouse model containing the 54-kilobase hTERT gene locus inserted into its genome (hTERT-BAC) was utilized. The gastrocnemius, left ventricle, and brain were excised before (Pre), upon cessation (Post), and during recovery (1, 24, 48, and 72 h; n = 5/time point) from treadmill running (30 min at 60% maximum speed). Full-length (FL) hTERT and the “minus beta” (−β) AS variant (skips exons 7 and 8 and does not code for active telomerase) were measured by gel-based and droplet digital reverse transcription–polymerase chain reaction methods. SF3B4 and SRSF2 protein expression were measured by Western blotting.

Results
Compared with Pre, FL hTERT increased at Post before decreasing during recovery in the gastrocnemius (48 and 72 h; P ≤ 0.001) and left ventricle (24 h; P = 0.004). The percentage of FL hTERT in the gastrocnemius also increased during recovery (1 and 72 h; P ≤ 0.017), whereas a decrease was observed in the left ventricle (1, 24, and 48 h; P ≤ 0.041). hTERT decreased in the brain (48 h), whereas FL hTERT percentage remained unaltered. SF3B4 protein expression decreased throughout recovery in the gastrocnemius and tended to be associated with FL hTERT (r = −0.348, P = 0.075) and –β in opposite directions (r = 0.345, P = 0.067).

Conclusions
Endurance exercise increased hTERT gene expression, and altered FL hTERT splicing in contractile tissues and may maintain telomere length necessary to improve the function and health of the organism.
The Timing of Thigh Muscle Activity Is a Factor Limiting Performance in the Deceleration Phase of the 100-m Dash
Authors: KAKEHATA GAKU , GOTO YUTA , ISO SHIGEO , KANOSUE KAZUYUKI 
Published: February 2022

ABSTRACT

Purpose
We aimed to examine the timing of electromyography activity of the rectus femoris (RF) and biceps femoris (BF) in both legs, as well as spatiotemporal variables (running speed (RS), step frequency (SF), step length (SL)) between the maximal speed (Max) phase (50–70 m) and the deceleration (Dec) phase (80–100 m) of the 100-m dash.

Methods
Nine track and field athletes performed the 100-m dash with maximal effort. Spatiotemporal variables of each 10-m section were measured. A portable wireless data logger was attached to the subject’s lower back to record electromyographies. We calculated onset/offset timing (%) of RF and BF in both legs using a Teager–Kaiser Energy Operator filter (e.g., ipsilateral leg RF onset is “iRF-onset,” contralateral leg BF onset is “cBF-onset”) in a running cycle.

Results
The decreased RS in the Dec phase (P < 0.001) was due to a decreased SF (P < 0.001). Moreover, iRF-onset (P = 0.002), iRF-offset (P = 0.008), iBF-offset (P = 0.049), and cBF-offset (P = 0.017) in the Dec phase lagged in the running cycle as compared with the Max phase. Furthermore, the time difference between the swing leg RF activity (iRF-onset) and the contact leg BF activity (cBF-onset; “Scissors1”) became bigger in the Dec phase (P = 0.041). Significant negative correlations were found between ΔiRF-onset and ΔSF (P = 0.045), and between ΔiBF-offset and ΔSF (P = 0.036).

Conclusions
The decreased RS and SF in the Dec phase of the 100-m dash would be the delayed timing of the RF and BF activities in the same leg as well as the disturbed interleg muscular coordination.
Comparison of Blood Pressure and Vascular Health in Physically Active Late Pre- and Early Postmenopausal Females
Authors: DEBRAY AMELIE , ENEA CARINA , RAVANELLI NICHOLAS , CHASELING GEORGIA KATE , GRAVEL HUGO , BOSQUET LAURENT , BHERER LOUIS , GAGNON DANIEL 
Published: February 2022

ABSTRACT

Purpose
The benefits of exercise on vascular health are inconsistent in postmenopausal females. We investigated if blood pressure and markers of vascular function differ between physically active early post- and late premenopausal females.

Methods
We performed a cross-sectional comparison of 24-h blood pressure, brachial artery flow-mediated dilation, microvascular reactivity (reactive hyperemia), carotid–femoral pulse wave velocity, and cardiac baroreflex sensitivity between physically active late premenopausal (n = 16, 48 ± 2 yr) and early postmenopausal (n = 14, 53 ± 2 yr) females.

Results
Physical activity level was similar between premenopausal (490 ± 214 min·wk−1) and postmenopausal (550 ± 303 min·wk−1) females (P = 0.868). Brachial artery flow-mediated dilation (pre, 4.6 ± 3.9, vs post, 4.7% ± 2.2%; P = 0.724), 24-h systolic (+5 mm Hg, 95% confidence interval [CI] = –1 to +10, P = 0.972) and diastolic (+4 mm Hg, 95% CI = –1 to +9, P = 0.655) blood pressures, total reactive hyperemia (pre, 1.2 ± 0.5, vs post, 1.0 ± 0.5 mL·mm Hg−1; P = 0.479), carotid–femoral pulse wave velocity (pre, 7.9 ± 1.7, vs post, 8.1 ± 1.8 m·s−1; P = 0.477), and cardiac baroreflex sensitivity (−8 ms·mm Hg−1, 95% CI = –20.55 to 4.62, P = 0.249) did not differ between groups. By contrast, peak reactive hyperemia (−0.36 mL·min−1⋅mm Hg−1, 95% CI = –0.87 to +0.15, P = 0.009) was lower in postmenopausal females.

Conclusions
These results suggest that blood pressure and markers of vascular function do not differ between physically active late pre- and early postmenopausal females.
Association of Physical Activity with Incidence of Dementia Is Attenuated by Air Pollution
Authors: RAICHLEN DAVID A. , FURLONG MELISSA , KLIMENTIDIS YANN C. , SAYRE M. KATHERINE , PARRA KIMBERLY L. , BHARADWAJ PRADYUMNA K. , WILCOX RAND R. , ALEXANDER GENE E. 
Published: February 2022

ABSTRACT

Introduction
Physical activity (PA) is recognized as one of the key lifestyle behaviors that reduces risk of developing dementia late in life. However, PA also leads to increased respiration, and in areas with high levels of air pollution, PA may increase exposure to pollutants linked with higher risk of developing dementia. Here, we investigate whether air pollution attenuates the association between PA and dementia risk.

Methods
This prospective cohort study included 35,562 adults 60 yrs and older from the UK Biobank. Average acceleration magnitude (ACCave) from wrist-worn accelerometers was used to assess PA levels. Air pollution levels (NO, NO2, PM10, PM2.5, PM2.5–10, and PM2.5 absorbance) were estimated with land use regression methods. Incident all-cause dementia was derived from inpatient hospital records and death registry data.

Results
In adjusted models, ACCave was associated with reduced risk of developing dementia (HR = 0.71, 95% confidence interval [CI] = 0.60–0.83), whereas air pollution variables were not associated with dementia risk. There were significant interactions between ACCave and PM2.5 (HRinteraction = 1.33, 95% CI = 1.13–1.57) and PM2.5 absorbance (HRinteraction = 1.24, 95% CI = 1.07–1.45) on incident dementia. At the lowest tertiles of pollution, ACCave was associated with reduced risk of incident dementia (HRPM 2.5 = 0.66, 95% CI = 0.49–0.91; HRPM 2.5 absorbance = 0.60, 95% CI = 0.44–0.81). At the highest tertiles of these pollutants, there was no significant association of ACCave with incident dementia (HRPM 2.5 = 0.88, 95% CI = 0.68–1.14; HRPM 2.5 absorbance = 0.79, 95% CI = 0.60–1.04).

Conclusions
PA is associated with reduced risk of developing all-cause dementia. However, exposure to even moderate levels of air pollution attenuates the benefits of PA on risk of dementia.
Relationship between Anterior Pituitary Volume and IGF-1 Serum Levels in Soldiers with Mild Traumatic Brain Injury History
Authors: CASTELLANO ANNA K. , POWELL JACOB R. , COOLS MICHAEL J. , WALTON SAMUEL R. , BARNETT RANDALINE R. , DELELLIS STEPHEN M. , GOLDBERG RICHARD L. , KANE SHAWN F. , MEANS GARY E. , ZAMORA CARLOS A. , DEPENBROCK PATRICK J. , MIHALIK JASON P. 
Published: February 2022

ABSTRACT

Purpose
A high mild traumatic brain injury (mTBI) incidence rate exists in military and sport. Hypopituitarism is an mTBI sequela; however, few studies have examined this phenomenon in those with an mTBI history. This cross-sectional study of Special Operations Forces combat soldiers aimed 1) to relate anterior pituitary gland volumes (actual and normalized) to insulin-like growth factor 1 (IGF-1) concentrations, 2) to examine the effect of mTBI history on anterior pituitary gland volumes (actual and normalized) and IGF-1 concentrations, and 3) to measure the odds of demonstrating lower anterior pituitary gland volumes (actual and normalized) or IGF-1 concentrations if self-reporting mTBI history.

Methods
Anterior pituitary gland volumes were manually segmented from T1-weighted 3D brain MRI sequences; IGF-1 serum concentrations were quantified using commercial enzyme-linked immunosorbent assays. Correlations and linear regression were used to determine the association between IGF-1 serum concentration and anterior pituitary gland volume (n = 74). Independent samples t-tests were used to compare outcomes between mTBI groups and logistic regression models were fit to test the odds of demonstrating IGF-1 concentration or anterior pituitary volume less than sample median based on mTBI group (n = 54).

Results
A significant linear relationship between the subjects’ anterior pituitary gland volumes and IGF-1 concentrations (r
72 = 0.35, P = 0.002) was observed. Soldiers with mTBI history had lower IGF-1 concentrations (P < 0.001) and lower anterior pituitary gland volumes (P = 0.037) and were at greater odds for IGF-1 serum concentrations less than the sample median (odds ratio = 5.73; 95% confidence interval = 1.77–18.55).

Conclusions
Anterior pituitary gland volume was associated with IGF-1 serum concentrations. Mild TBI history may be adversely associated with anterior pituitary gland volumes and IGF-1 concentrations. Longitudinal IGF-1 and anterior pituitary gland monitoring may be indicated in those who report one or more mTBI.