bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma advanced glycation end products and the subsequent risk of microvascular complications in type 1 diabetes in the DCCT/EDIC
Authors: Monnier Vincent M , Sell David R , Gao Xiaoyu , Genuth Saul M , Lachin John M , Bebu Ionut 
Published: January 2022

IntroductionTo assess impact of glycemic control on plasma protein-bound advanced glycation end products (pAGEs) and their association with subsequent microvascular disease.Research design and methodsEleven pAGEs were measured by liquid chromatography-mass spectrometry in banked plasma from 466 participants in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study at three time points (TPs): DCCT year 4 (TP1) and year 8 (TP2) and EDIC year 5/6 (TP3). Correlation coefficients assessed cross-sectional associations, and Cox proportional hazards models assessed associations with subsequent risk of microvascular complications through EDIC year 24.ResultsGlucose-derived glycation products fructose-lysine (FL), glucosepane (GSPN) and carboxymethyl-lysine (CML) decreased with intensive glycemic control at both TP1 and TP2 (p<0.0001) but were similar at TP3, and correlated with hemoglobin A1c (HbA1c). At TP1, the markers were associated with the subsequent risk of several microvascular outcomes. These associations did not remain significant after adjustment for HbA1c, except methionine sulfoxide (MetSOX), which remained associated with diabetic kidney disease. In unadjusted models using all 3 TPs, glucose-derived pAGEs were associated with subsequent risk of proliferative diabetic retinopathy (PDR, p<0.003), clinically significant macular edema (CSME, p<0.015) and confirmed clinical neuropathy (CCN, p<0.018, except CML, not significant (NS)). Adjusted for age, sex, body mass index, diabetes duration and mean updated HbA1c, the associations remained significant for PDR (FL: p<0.002, GSPN: p≤0.02, CML: p<0.003, pentosidine: p<0.02), CMSE (CML: p<0.03), albuminuria (FL: p<0.02, CML: p<0.03) and CCN (FL: p<0.005, GSPN : p<0.003).ConclusionspAGEs at TP1 are not superior to HbA1c for risk prediction, but glucose-derived pAGEs at three TPs and MetSOX remain robustly associated with progression of microvascular complications in type 1 diabetes even after adjustment for HbA1c and other factors.
Correlation between chest CT and RT-PCR testing in India’s second COVID-19 wave: a retrospective cohort study
Authors: Mehta Vishal , Jyoti Divya , Guria Rishi Tuhin , Sharma Chandra Bhushan 
Published: January 2022

ObjectivesTo assess the diagnostic accuracy of chest CT in clinically suspected patients with COVID-19 using reverse transcriptase PCR (RT-PCR) as the reference standard and establish the correlation between CT Severity Score (CTSS) and RT-PCR results.Design and settingRetrospective cohort study. Single-centre tertiary care hospital-based study.ParticipantsWe enrolled 112 clinically suspected patients with COVID-19 between 1 April 2021 and 31 May 2021. Chest CT and RT-PCR tests were performed for all patients at a time interval of no longer than 7 days between the two tests. Patients with prior chronic respiratory illnesses were excluded. The diagnostic performance of chest CT was evaluated using RT-PCR as the reference standard. The CTSS was calculated for all patients with positive chest CT findings, and it was correlated with results of the RT-PCR assay.Main outcome measuresThe primary outcome measures were determination of the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of chest CT using RT-PCR as the standard of reference. The correlation between CTSS and RT-PCR was the secondary outcome.Results85/112 (76%) patients tested positive on the RT-PCR whereas 91/112 (81%) had chest CT findings typical of SARS-CoV-2 infection. Chest CT had a sensitivity of 90.6% (95% CI 82.3% to 95.8%), a specificity of 48.1% (95% CI 28.7% to 68.0%), a PPV of 84.6% (95% CI 79.2% to 88.8%), an NPV of 61.9% (95% CI 43.0% to 77.8%) and an accuracy of 80.4% (95% CI 71.8% to 87.3%). There was a significant correlation between the CTSS and RT-PCR positivity (p value=0.003).ConclusionIn our experience, chest CT has a good sensitivity and provides a reliable diagnostic tool for moderate-to-severe COVID-19 cases in resource limited settings.
Study protocol of the European Urban Burden of Disease Project: a health impact assessment study
Authors: Nieuwenhuijsen Mark J , Barrera-Gómez Jose , Basagaña Xavier , Cirach Marta , Daher Carolyn , Pulido Maria Foraster , Iungman Tamara , Gasparrini Antonio , Hoek Gerard , de Hoogh Kees , Khomenko Sasha , Khreis Haneen , de Nazelle Audrey , Ramos Ana , Rojas-Rueda David , Pereira Barboza Evelise , Tainio Marko , Thondoo Meelan , Tonne Cathryn , Woodcock James , Mueller N 
Published: January 2022

IntroductionCities have long been known to be society’s predominant engine of innovation and wealth creation, yet they are also hotspots of pollution and disease partly due to current urban and transport practices. The aim of the European Urban Burden of Disease project is to evaluate the health burden and its determinants related to current and future potential urban and transport planning practices and related exposures in European cities and make this evidence available for policy and decision making for healthy and sustainable futures.Methods and analysisDrawing on an established comparative risk assessment methodology (ie, Urban and Transport Planning Health Impact Assessment) tool), in nearly 1000 European cities we will (1) quantify the health impacts of current urban and transport planning related exposures (eg, air pollution, noise, excess heat, lack of green space) (2) and evaluate the relationship between current levels of exposure, health impacts and city characteristics (eg, size, density, design, mobility) (3) rank and compare the cities based on exposure levels and the health impacts, (4) in a number of selected cities assess in-depth the linkages between urban and transport planning, environment, physical activity and health, and model the health impacts of alternative and realistic urban and transport planning scenarios, and, finally, (5) construct a healthy city index and set up an effective knowledge translation hub to generate impact in society and policy.Ethics and disseminationAll data to be used in the project are publicly available data and do not need ethics approval. We will request consent for personal data on opinions and views and create data agreements for those providing information on current and future urban and transport planning scenarios.For dissemination and to generate impact, we will create a knowledge translation hub with information tailored to various stakeholders.
Supported self-management in community stroke rehabilitation: what is it and how does it work? A protocol for a realist evaluation study
Authors: Kidd Lisa , Millar Julie Duncan , Mason Helen , Quinn Terry , Gallacher Katie I , Jones Fiona , Fisher Rebecca J , Lebedis Therese , Barber Mark , Brennan Katrina , Smith Mark 
Published: January 2022

IntroductionA growing evidence base demonstrates the effectiveness of supported self-management in stroke for stroke survivors and their families. However, there is significant variation in its implementation in community stroke care and little understanding about how supported self-management works and is delivered across different settings, models used and contexts of community stroke rehabilitation.Methods and analysisUsing a mixed method, realist approach across two phases, this protocol describes a study on community-based supported self-management. The aim is to identify the mechanisms and outcomes of supported self-management in stroke and to understand how supported self-management is implemented in different contexts of community stroke rehabilitation. Phase 1 involves (1) a realist synthesis, (2) a scoping and mapping of current community rehabilitation settings and (3) a Q-methodology study to develop initial programme theories about how community-based supported self-management works, for whom and in what contexts. Phase 2 involves realist informed interviews/focus groups with stroke survivors, community rehabilitation practitioners and team managers from across Scotland to test and refine programme theories and an explanatory model for how supported self-management works across different contexts of community-based stroke rehabilitation.Ethics and disseminationEthical approval and R&D approvals have been granted from East of Scotland Research Ethics Committee (REC reference number: 19/ES/0055) and participating NHS boards. An understanding of how, for whom and in what contexts community-based supported self-management works will help to strengthen its delivery in practice. Such an understanding will enable the design of context-specific recommendations for policy and practice that genuinely reflect the challenges in implementing supported self-management in community stroke care. Results will be disseminated to clinical partners working in community stroke rehabilitation, stroke survivors and families and to policymakers and third sector partners involved in the provision of long-term support for people affected by stroke.PROSPERO registration numberCRD42020166208.
MArkerless image Guidance using Intrafraction Kilovoltage x-ray imaging (MAGIK): study protocol for a phase I interventional study for lung cancer radiotherapy
Authors: Mueller Marco , Booth Jeremy , Briggs Adam , Jayamanne Dasantha , Panettieri Vanessa , Senthi Sashendra , Shieh Chun-Chien , Keall Paul 
Published: January 2022

IntroductionIn radiotherapy, tumour tracking leads the radiation beam to accurately target the tumour while it moves in a complex and unpredictable way due to respiration. Several tumour tracking techniques require the implantation of fiducial markers around the tumour, a procedure that involves unnecessary risks and costs. Markerless tumour tracking (MTT) negates the need for implanted markers, potentially enabling accurate and optimal radiotherapy in a non-invasive way.Methods and analysisWe will perform a phase I interventional trial called MArkerless image Guidance using Intrafraction Kilovoltage x-ray imaging (MAGIK) to investigate the technical feasibility of the MTT technology developed at the University of Sydney (sponsor). 30 participants will undergo the current standard of care lung stereotactic ablative radiation therapy, with the exception that kilovoltage X-ray images will be acquired continuously during treatment delivery to enable MTT. If MTT indicates that the mean lung tumour position has shifted >3 mm, a warning message will be displayed to indicate the need for a treatment intervention. The radiation therapist will then pause the treatment, shift the treatment couch to account for the shift in tumour position and resume the treatment. Participants will be implanted with fiducial markers, which act as the ground truth for evaluating the accuracy of MTT. MTT is considered feasible if the tracking accuracy is <3 mm in each dimension for >80% of the treatment time.Ethics and disseminationThe MAGIK trial has received ethical approval from The Alfred Human Research Ethics Committee and has been registered with ClinicalTrials.gov with the Identifier: NCT04086082. Estimated time of first recruitment is early 2022. The study recruitment and data analysis phases will be performed concurrently. Treatment for all 30 participants is expected to be completed within 2 years and participant follow-up within a total duration of 7 years. Findings will be disseminated through peer-reviewed publications and conference presentations.Trial registration numberNCT04086082; Pre-result.
Interventions to reduce post-traumatic stress disorder symptoms in health care professionals from 2011 to 2021: a scoping review
Authors: Qian Jialu , Wang Weihong , Sun Shiwen , Liu Lu , Sun Yaping , Yu Xiaoyan 
Published: January 2022

ObjectivesThis scoping review aimed to describe available interventions for decreasing (post-traumatic stress disorder) PTSD symptoms among healthcare professionals in hospital care.MethodA scoping review was conducted following Arksey and O’Malley’s framework. PubMed, EMBASE, Cochrane Library, CINAHL, PsycINFO, Web of Science, Scopus and ProQuest were searched for original research published in English from 2011 to 2021, on 8 July 2021. We included studies that described interventions that focused on reducing the PTSD symptoms of healthcare professionals. A narrative synthesis was adopted to synthesise the data.ResultsA total of eight studies out of 2558 articles were identified. Six used a quantitative study design and two adopted qualitative methods. cognitive behavioural therapy and mindfulness-based interventions were the most commonly adopted. Most studies used a combination of different intervention strategies. Trauma-related knowledge, emotion regulation and relaxation skill training, and psychological support from peers and psychologists were three core intervention components. The duration ranged from 2 weeks to 6 months. Healthcare professionals who participated in training programmes reported both positive experiences and suggestions for the improvement of PTSD-reducing interventions in their qualitative feedback.ConclusionsThe scoping review provides a practical summary of the intervention characteristics for reducing the PTSD symptoms of healthcare professionals. Hospitals and managers could use the overview of interventions to assist healthcare professionals with PTSD symptoms. More research investigating the effects of PTSD symptom-reducing interventions for healthcare professionals with appropriate follow-up assessments is needed in the future.
Diversity of physicians in leadership and academic positions in Alberta: a cross-sectional survey
Authors: Ruzycki Shannon M , Roach Pamela , Ahmed Sofia B , Barnabe Cheryl , Holroyd-Leduc Jayna 
Published: January 2022

BackgroundEfforts to reduce barriers and disparities faced by marginalised physicians are limited by a lack of data on the current diversity of the Canadian physician workforce. We aimed to characterise the diversity of the Albertan physician workforce.MethodsThis cross-sectional survey, open to all Albertan physicians from 1 September 2020 to 6 October 2021, measured the proportion of physicians from traditionally under-represented groups, including those with diverse gender identities, disabilities and from racial minorities.ResultsThere were 1087 respondents (9.3% response rate); of whom 33.4% identified as cisgender men (n=363), 46.8% as cisgender women (n=509) and less than 3% as gender diverse. Fewer than 5% were members of the LGBTQI2S+community. Half were white (n=547), 4.6% were black (n=50) and fewer than 3% were Indigenous or Latinx. Over one-third reported a disability (n=368, 33.9%). There were 303 white cisgender women (27.9%), 189 white cisgender men (17.4%), 136 black, Indigenous or person of colour (BIPOC) cisgender men (12.5%) and 151 BIPOC cisgender women (13.9%). Compared with BIPOC physicians, white participants were over-represented in leadership positions (64.2% and 32.1%; p=0.06) and academic roles (78.7% and 66.9%; p<0.01). Cisgender women had less often applied for academic promotion than cisgender men (85.4% and 78.3%, respectively, p=0.01), and BIPOC physicians had been denied promotion more frequently (7.7% compared with 4.4%; p=0.47).ConclusionMany Albertan physicians may experience marginalisation through at least one protected characteristic. There were race-based and gender-based differences in experiences of medical leadership and academic promotion which may explain observed disparities in these positions. To increase diversity and representation in medicine, medical organisations should focus on inclusive cultures and environments. Universities should focus efforts on supporting BIPOC physicians, especially BIPOC cisgender women, in applying for promotion.
Therapeutic effect of rupatadine against l-arginine-induced acute pancreatitis in rats: role of inflammation
Authors: Mohamed Mervat Z. , Mohammed Hanaa H. , Khalaf Hanaa M. 
Published: January 2022

Acute pancreatitis (AP) is an abrupt inflammatory disorder causing high morbidity and mortality. As AP is an insidious medical emergency, a curative modality is required instead of a preventive measure. Thus, we investigated the possible curative effect of rupatadine on a rat model of AP. Rupatadine is a potent histamine receptor 1 (H1R) and platelet-activating factor (PAF) blocker. We used four groups of six Wistar rats as follows: the control group received vehicle; the rupatadine control group received rupatadine as 6 mg/kg orally; the AP group received l-arginine intraperitoneally, and the treatment group received rupatadine at 1, 6, and 24 h after l-arginine injection. The levels of serum amylase, pancreatic oxidative parameters, and pancreatic cytokines were measured. PAF, histamine, and myeloperoxidase levels were determined in the pancreas. Histopathological and immunohistochemical examinations were performed to determine nuclear factor kappa-B (NF-κB) and caspase 3 expressions. Oxidative damage and severe inflammation were detected in the pancreas of the AP group. Rupatadine reduced the oxidative damage and the levels of proinflammatory cytokines, PAF, histamine, myeloperoxidase, NF-κB, and caspase 3 expressions. It restored the pancreatic acini to almost normal condition. Rupatadine induced important anti-inflammatory and antiapoptotic effects against l-arginine-induced AP.
O contexto de produção e as fotografias nos arquivos pessoais: um estudo nos artigos de periódicos da Ciência da Informação e Arquivologia
Authors: Mariz Anna Carla Almeida , Cordeiro Rosa Inês de Novais 
Published: January 2022

Estudo resultante de pesquisa bibliográfica sobre arquivos pessoais, nos quais normalmente são encontrados documentos de gêneros diversos, entre eles as fotografias com muita frequência, evidenciando-se a importância desses acervos para a memória individual e familiar. São as características organicidade e autenticidade que qualificam os arquivos pessoais e suas fotografias como tais e os diferem das coleções. Este trabalho tem como objetivo verificar como são enfocados esses acervos na literatura em língua portuguesa de artigos de periódicos, com destaque para o estudo da questão do contexto de produção das fotografias nos arquivos pessoais e a observância desses registros visuais, a partir das seguintes categorias de análise: enfoque do tema, campo empírico e resultados. O tratamento técnico desses documentos apresenta especificidades, e cumpre examinar se a literatura da área vem registrando essas mudanças quanto aos aspectos teóricos e empíricos de organização e no que se refere ao crescimento desses acervos em quantidade e em importância. Para tanto, foi realizada pesquisa bibliográfica na literatura em língua portuguesa em artigos de periódicos da área da Ciência da Informação e Arquivologia, com uma abordagem quanti-qualitativa e observância às categorias de análise. Constata-se que, da mesma forma que a literatura sobre acervos fotográficos pouco evidencia os arquivos pessoais, o inverso também acontece: a literatura sobre arquivos pessoais pouco ressalta os documentos fotográficos, um gênero documental encontrado com muita frequência nos acervos pessoais e familiares. São dois temas que têm relação, porém a literatura contemplando a interseção entre eles é muito escassa, especialmente no recorte escolhido.
The Effect of an Equatorial Continent on the Tropical Rain Belt. Part II: Summer Monsoons
Authors: Biasutti Michela , Hill Spencer , Voigt Aiko 
Published: January 2022

Abstract
The TRACMIP (Tropical Rain Belts with an Annual Cycle and Continent Model Intercomparison Project) ensemble includes slab-ocean aquaplanet control simulations and experiments with a highly idealized narrow tropical continent (0°–45°W, 30°S–30°N). We compare the two setups to contrast the characteristics of oceanic and continental rainbands and investigate monsoon development in GCMs with CMIP5-class dynamics and physics. Over land, the rainy season occurs close to the time of maximum insolation. Other than in its timing, the continental rainband remains in an ITCZ-like regime akin to deep-tropical monsoons, with a smooth latitudinal transition, a poleward reach only slightly farther than that of the oceanic ITCZ (about 10°), and a constant width throughout the year. This confinement of the monsoon to the deep tropics is the result of a tight coupling between regional rainfall and circulation anomalies: ventilation of the lower troposphere by the anomalous meridional circulation is the main limiting mechanism, while ventilation by the mean westerly jet aloft is secondary. Comparison of two subsets of TRACMIP simulations indicates that a low heat capacity determines, to a first degree, both the timing and the strength of the regional solsticial circulation; this lends support to the choice of idealizing land as a thin slab ocean in much theoretical literature on monsoon dynamics. Yet, the timing and strength of the monsoon are modulated by the treatment of evaporation over land, especially when moisture and radiation can interact. This points to the need for a fuller exploration of land characteristics in the hierarchical modeling of the tropical rainbands.
Arthroscopic Latarjet: 2 or 4 Cortical Buttons for Coracoid Fixation? A Case-Control Comparative Study
Authors: Barret Hugo , Chelli Mikael , Van Der Meijden Olivier , Langlais Tristan , Boileau Pascal 
Published: January 2022

Background: While 2 screws are traditionally used for coracoid bone block fixation, no gold standard technique has yet been established when using cortical buttons. Purpose: To compare anatomic and clinical outcomes of the arthroscopic Latarjet procedure using either 2 or 4 buttons for coracoid bone block fixation. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 23 patients with 4-button fixation (group 4B) were matched for age at surgery, sex, and follow-up to 46 patients who had 2-button fixation (group 2B). All patients underwent guided arthroscopic Latarjet (using coracoid and glenoid guides), and a tensioning device was used to rigidify the suture button construct and get intraoperative bone block compression. The primary outcome was assessment of bone block positioning and healing using computed tomography scans performed at 2 weeks and at least 6 months after surgery. The mean ± standard deviation follow-up was 49 ± 7 months (range, 24-64 months). Results: The bone block healing rate was similar in both groups: 91% in group 4B versus 95.5% in group 2B. The transferred coracoid was flush to the glenoid surface in 21 patients (91%) in group 4B and 44 patients (96%) in group 2B ( P = .6); it was under the equator in 22 patients (96%) in group 4B and 44 patients (96%) in group 2B ( P≥ .99). There was no secondary bone block displacement; the rate of bone block resorption was similar between the groups: 28% in group 4B and 23% in group 2B ( P = .71). Patient-reported outcomes, return to sports, and satisfaction were also similar between the groups. The operating time was significantly longer in group 4B (95 vs 75 minutes; P = .009). Conclusion: A 4-button fixation technique did not demonstrate any anatomic or clinical advantages when compared with a 2-button fixation technique, while making the procedure more complex and lengthening the operating time by 20 minutes. A 2-button fixation is simple, safe, and sufficient to solidly fix the transferred coracoid bone block. The use of drill guides allows accurate graft placement, while the use of a tensioning device to rigidify the suture button construct provides high rates of bone block healing with both techniques (>90%).