bluuebunny/crossref_metadata_2025_split huggingface dataset:
The End of the Present Mode of Production – A New Kondratieff Wave? – New Directions for Research?
Authors: Philipson Sarah 
Published: March 2022

This conceptual paper traces the history of production from simple offerings, with the logic of a product structure to a virtual structure, then how components are outsourced in a supply chain. In Wintelism, individual functions, within a product architecture and specified interfaces, are outsourced. Focal firms view the value chain as an ecosystem to optimize value. Destructive innovation restruct and destruct ecosystems that are outperformed by ecosystems providing new offerings. Fundamental destructive innovations disrupt the very way production is made, the mode of production, replacing it by another. This paper raises the question if we are close to such a fundamental disruption.
Impact of High-Flux Hemodialysis on Chronic Inflammation, Antioxidant Capacity, Body Temperature, and Immune Function in Patients with Chronic Renal Failure
Authors: Li Sufang , Li Hongwei , Wang Jun , Yin Lianliang 
Published: March 2022

In order to probe into the impact of high-flux dialysis and hemodiafiltration on patients with chronic rental failure, this paper selects in total 92 cases with chronic renal failure receiving hemodialysis from November 2018 to July 2021, allocating them into two groups based on the random table, each with 46 cases. The control group received hemodiafiltration, the observation group is given high-flux hemodialysis, and we compared serum inflammatory factor level and antioxidant factor level before and after treatment, as well as cellular immune factor level (CD3+, CD4+) and humoral immune factor level (IgE) before and after treatment in the two groups; the renal function, serum total calcium ion level, and serum phosphorus ion level in the two groups were compared before and after treatment, as well as the proportion of metabolic abnormalities in calcium and phosphorus ion levels during treatment; the trend of changes in axillary temperature during treatment in the two groups is analyzed. After treatment, serum inflammatory factor level (hs-CRP & TNF-α) is lower than that in the control group (

P

< 0.05), antioxidant factor level (MDA) is lower than that in the control group (

P

< 0.05), and SOD level is higher than that in the control group (

P

< 05). After treatment CD3+ and CD4+ levels in the observation group are higher than those in the control group (

P

< 0.05). For patients with chronic renal failure, high-flux hemodialysis is available to better reduce inflammatory response, improve antioxidant and immune capacity in the body, and help maintain calcium and phosphorus metabolic balance.
Performance Evaluation of the Newly Operational NDBC 2.1-m Hull
Authors: Hall Candice , Jensen Robert E. , Wang David W. 
Published: March 2022

Abstract
The importance of quantifying the accuracy in wave measurements is critical to not only understand the complexities of wind-generated waves, but imperative for the interpretation of implied accuracy of the prediction systems that use these data for verification and validation. As wave measurement systems have unique collection and processing attributes that result in large accuracy ranges, this work quantifies bias that may be introduced into wave models from the newly operational NOAA National Data Buoy Center (NDBC) 2.1-m hull. Data quality consistency between the legacy NDBC 3-m aluminum hulls and the new 2.1-m hull is compared to a relative reference, and provides a standardized methodology and graphical representation template for future intrameasurement evaluations. Statistical analyses and wave spectral comparisons confirm that the wave measurements reported from the NDBC 2.1-m hulls show an increased accuracy from previously collected NDBC 3-m hull wave data for significant wave height and average wave period, while retaining consistent accuracy for directional results, purporting that hull size does not impact NDBC directional data estimates. Spectrally, the NDBC 2.1-m hulls show an improved signal-to-noise ratio, allowing for increase in energy retention in the lower-frequency spectral range, with an improved high-frequency spectral accuracy above 0.25 Hz within the short seas and wind chop wave component regions. These improvements in both NDBC bulk and spectral data accuracy provide confidence for the wave community’s use of NDBC wave data to drive wave model technologies, improvements, and validations.
Serum D-dimer level as a predictor of neurological functional prognosis in cases of head injuries caused by road traffic accidents
Authors: Asami Masahiro , Nakahara Shinji , Miyake Yasufumi , Kanda Jun , Onuki Takahiro , Matsuno Akira , Sakamoto Tetsuya 
Published: March 2022

Abstract
Background
The number of traffic fatalities is declining in Japan; however, a large proportion of head injuries are still attributable to traffic accidents. Severe head trauma may cause progressive and devastating coagulopathy owing to exacerbated coagulation and fibrinolysis, which results in massive bleeding and poor patient outcomes. D-dimer is a fibrinolytic marker, which remarkably increases in severe coagulopathy due to the exacerbated fibrinolytic system. Because the degree of coagulopathy is associated with patient outcomes, the D-dimer level is a useful prognostic predictor in patients with head trauma. However, the usefulness of D-dimer in cases of head trauma caused by road traffic accidents remains inadequately explored. In this study, we investigated the relationship between D-dimer levels and outcomes in head injuries caused by traffic accidents.

Methods
We extracted data on traffic injuries from Japan Neuro-Trauma Data Bank Project 2015, which is a prospective multicenter registry of head injuries. The analysis included 335 individuals with no missing data. The outcome variable was the score of the Glasgow Outcome Scale (GOS), a neurological outcome index. The participants were categorized into the favorable outcome (GOS score ≥ 4) and poor outcome (GOS score ≤ 3) groups. The serum D-dimer levels at the time of admission were divided into four categories at the quartiles, and the reference category was less than the first quartile (< 17.4 µg/mL). We performed a logistic regression analysis with GOS as the dependent variable and D-dimer as a predictor and performed a multivariate analysis that was adjusted for 10 physiological parameters.

Results
In the univariate analysis, all groups with serum D-dimer values ≥ 17.4 μg/dL showed significantly poorer outcomes than those of the reference group. In the multivariate analysis, after adjusting for other factors, D-dimer levels ≥ 89.3 μg/dL were an independent predictor of poor outcome.

Conclusion
After adjusting for physiological parameters, high serum D-dimer levels can be an independent factor for predicting neurological prognosis in head trauma caused by road traffic accidents.
The association between hypertension and the risk of gallstone disease: a cross-sectional study
Authors: Zhang Yalan , Sun Li , Wang Xin , Chen Zongtao 
Published: March 2022

Abstract
Background
To explore the association between hypertension and the risk of gallstone disease.

Methods
We collected the data about the subjects receiving physical examination. Gallstone disease was diagnosed by abdominal ultrasound. Multivariable logistic regression was used to study the association between blood pressure and the risk of gallstone disease. SPSS version 23.0 was used for statistical analysis, and two-tailed P < 0.05 was defined as statistically significant.

Results
A total of 318,403 people were included in the study and 171,276 (53.8%) of them were men and 147,127 (46.2%) were women. Among them, 27,463 (8.6%) were diagnosed with gallstone disease on ultrasound examination, with 12,452 (3.9%) cases of gallstones and 15,017 (4.7%) cases of cholecystectomy. Multivariable logistic regression showed that hypertension was significantly associated with the risk of gallstone disease (OR = 1.05; 95% CI: 1.02–1.10; P = 0.03) and gallstones (OR = 1.12; 95% CI: 1.06–1.19; P < 0.01) and the association between hypertension and gallstone disease was stronger in women than in men. However, hypertension was not significantly correlated with cholecystectomy (OR = 0.99; 95% CI: 0.95–1.04; P = 0.85). Additionally, results showed that with the severity of hypertension increased, the risk of gallstone disease was also marked elevated (P for trend < 0.001).

Conclusions
The gallstone disease was prevalent and hypertension is significantly associated with the gallstone disease risk with a significant dose–response association. This study showed that the association between hypertension and cholecystectomy was not statistically significant, maybe hypertension correlated with gallstones but not with symptomatic gallstone disease which would require cholecystectomy.
Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency
Authors: Imoto Koji , Tanaka Masatake , Goya Takeshi , Aoyagi Tomomi , Takahashi Motoi , Kurokawa Miho , Tashiro Shigeki , Kato Masaki , Kohjima Motoyuki , Ogawa Yoshihiro 
Published: March 2022

Abstract
Background
Ornithine transcarbamylase deficiency (OTCD) is most common among urea cycle disorders (UCDs), defined by defects in enzymes associated with ureagenesis. Corticosteroid administration to UCD patients, including OTCD patients, is suggested to be avoided, as it may induce life-threatening hyperammonemia. The mechanism has been considered nitrogen overload due to the catabolic effect of corticosteroids; however, the pathophysiological process is unclear.

Methods
To elucidate the mechanism of hyperammonemia induced by corticosteroid administration in OTCD patients, we analyzed a mouse model by administering corticosteroids to OTCspf−ash mice deficient in the OTC gene. Dexamethasone (DEX; 20 mg/kg) was administered to the OTCspf−ash and wild-type (WT) mice at 0 and 24 h, and the serum ammonia concentrations, the levels of the hepatic metabolites, and the gene expressions related with ammonia metabolism in the livers and muscles were analyzed.

Results
The ammonia levels in Otcspf−ash mice that were administered DEX tended to increase at 24 h and increased significantly at 48 h. The metabolomic analysis showed that the levels of citrulline, arginine, and ornithine did not differ significantly between Otcspf−ash mice that were administered DEX and normal saline; however, the level of aspartate was increased drastically in Otcspf−ash mice owing to DEX administration (P < 0.01). Among the enzymes associated with the urea cycle, mRNA expressions of carbamoyl-phosphate synthase 1, ornithine transcarbamylase, arginosuccinate synthase 1, and arginosuccinate lyase in the livers were significantly downregulated by DEX administration in both the Otcspf−ash and WT mice (P < 0.01). Among the enzymes associated with catabolism, mRNA expression of Muscle RING-finger protein-1 in the muscles was significantly upregulated in the muscles of WT mice by DEX administration (P < 0.05).

Conclusions
We elucidated that corticosteroid administration induced hyperammonemia in Otcspf−ash mice by not only muscle catabolism but also suppressing urea-cycle-related gene expressions. Since the urea cycle intermediate amino acids, such as arginine, might not be effective because of the suppressed expression of urea-cycle-related genes by corticosteroid administration, we should consider an early intervention by renal replacement therapy in cases of UCD patients induced by corticosteroids to avoid brain injuries or fatal outcomes.
Effects of supportive counseling using a positive psychology approach on coping patterns among pregnant women with nausea and vomiting
Authors: Abbasi Mina , Maleki Azam , Ebrahimi Loghman , Molaei Behnaz 
Published: March 2022

Abstract
Background
Pregnancy nausea and vomiting (NVP) are associated with a wide range of physical and mental changes in the mothers and could affect their adaptation to pregnancy. There is a gap of knowledge regarding the effectiveness of a positive psychology approach counselling on improving coping patterns in women with NVP.

Objective
This study aimed to determine the effect of supportive counselling with a positive psychology approach on improving coping patterns in women with NVP.

Method
The current study was a randomized controlled trial on 60 pregnant women who experienced nausea and vomiting in Zanjan a province in the northwest of Iran, 2020–2021. Using four-block random sampling, eligible women were randomly assigned to the intervention and control groups. According to the Seligman protocol, the intervention group received supportive counselling in six sessions of 45 min3 times a week. The revised prenatal coping inventory (Nu PCI) was used to collect data and analyzed using Chi-square, repeated measures ANOVA, and MANOVA at a 95% confidence level.

Results
In the counseling group, the mean (SD) of a total score of coping with pregnancy before the intervention was 6.11 (1.31) which increased to 8.40 (1.03) in 4 weeks after the intervention. Based on the MANOVA test with adjusting the number of pregnancies, the mean total score of coping with pregnancy was statistically significant 4 weeks after the intervention compared with the control group (Adjusted mean difference (AMD) = -1.84, CI95% -2.36, -1.32, p = 0.001).

Conclusion
The use of positive psychology in supportive counselling improved the coping of mothers suffering from nausea and vomiting during pregnancy. It is recommended that this approach be incorporated into prenatal care to promote the health of pregnant women.

Trial registration
The study was registered at the Iranian Registry of Clinical Trials website under the code IRCT20150731023423N17.
Registration date: 2020–10-31, Expected recruitment start date: 2020–11-01.
IRCT Id: IRCT20150731023423N17.
Clinical practitioners’ experiences of psychological treatment for autistic children and adolescents with school attendance problems: a qualitative study
Authors: Melin Johanna , Jansson-Fröjmark Markus , Olsson Nora Choque 
Published: March 2022

Abstract
Background
School attendance problems (SAPs) are common among children and adolescents with autism spectrum disorder (ASD). Currently, there is a lack of guidelines for treatment or interventions aimed at this group.

Method
Twelve clinical practitioners were interviewed via in-depth interviews using a semi-structured question guide. Interviews were audiotaped, transcribed verbatim, and initially independently coded by two coders. The interviews were analyzed according to thematic analysis.

Results
The majority of the clinicians reported that it was common that children and adolescents with ASD at CAP had prolonged SAPs. A total of four themes and 22 sub-themes were identified in the analysis: the treatment situation; treatment goals at CAP; treatment interventions; and desired development. Insufficient adaptations in response to core impairment of ASD and lack of support in their daily life could be factors to the development of SAPs. Prolonged social isolation in combination with severe psychiatric comorbidities was reported as a treatment barrier. Also, insufficient collaboration between mental health care services, school and social services obstructed the return to school for this group of students. Favorable factors for positive treatment outcome were: early detection, accurate assessment and coordination between mental health care and schools and environmental adaptation at school as well as at home, parent support and sometimes change of school. Concerning useful therapeutic techniques, exposure from cognitive-behavioral treatment was reported.

Conclusion
Children and adolescents with ASD with limited societal support tend to develop SAPs. Important factors that impact the outcome of treatment were the length of the absence from school and the severity of psychiatric comorbidities. Tailored and adapted interventions at school, parent support and mental health care are needed. Research about assessment and treatment for children and adolescents with ASD and SAPs is needed.
Attitudes of German GP trainees regarding add-on training programs differ if in office or hospital training phase
Authors: Wild DMG , Linden K. , Welchowski T. , Dehnen D. , Weltermann B. 
Published: March 2022

Abstract
Background
Many residents are exposed to negative attitudes towards primary care during hospital training. Attractive add-on training programs exist, but it is unclear whether these need to be tailored to the location of training (hospital vs. office). We report differences in learner attitudes from a large German add-on training program.

Methods
Between 2017 and 2020, a regional network offered 31 quarterly seminars to primary care residents. The seminars addressed medical content, practice management and mentoring. We elicited participants’ satisfaction, perceived topic relevance, preferences for future seminars, work situation and employer support for participation. A proportionate odds model was used to assess predictors of ratings; results were stratified by training location (hospital vs. office).

Results
Most respondents were female (380/575 = 70.0%), aged between 26 and 40 (80.8%), and had on average 3.54 ± 1.64 years of residency training. The majority (83.8%) was working in an office and full-time (63.0%). Overall evaluations were positive (very satisfactory 72.1%). Comparing residents in the hospital phase vs. the office phase, overall seminar ratings of the perceived impact on the motivation for primary care did not differ (p = 0.73 vs. 0.18, respectively). Hospital-based residents were less likely to rate the topics as relevant (39.4% vs. 55.7%, p = 0.02) and had different preferences for future seminar topics (top 3: palliative care, emergencies and chronic care vs. billing, disease management and practice finances for hospital and office phase, respectively).

Conclusions
Keeping primary care residents motivated may require education tailored to training location. Our findings may be of interest to teachers, administrators and policymakers.
Experimenting with modifications to consent forms in comparative effectiveness research: understanding the impact of language about financial implications and key information
Authors: Niyibizi Nyiramugisha K. , Speight Candace D. , Najarro Gabriel , Mitchell Andrea R. , Sadan Ofer , Ko Yi-An , Dickert Neal W. 
Published: March 2022

Abstract
Background
Informed consent forms are intended to facilitate research enrollment decisions. However, the technical language in institutional templates can be unfamiliar and confusing for decision-makers. Standardized language describing financial implications of participation, namely compensation for injury and costs of care associated with participating, can be complex and could be a deterrent for potential participants. This standardized language may also be misleading in the context of comparative effectiveness trials of standard care interventions, in which costs and risk of injury associated with participating may not differ from regular medical care. In addition, the revised U.S. Common Rule contains a new requirement to present key information upfront; the impact of how this requirement is operationalized on comprehension and likelihood of enrollment for a given study is unknown.

Methods
Two online surveys assessed the impact of (1) changes to compensation for injury language (standard vs. tailored language form) and (2) changes to the key information page (using the tailored compensation language form with standard key information vs. modified key information vs. modified key information plus financial information) on both likelihood of enrollment in and understanding of a hypothetical comparative effectiveness trial.

Results
Likelihood of enrolling was not observed to be different between the standard and tailored language forms in Study 1 (73 vs. 75%; p = 0.6); however, the tailored language group had a higher frequency of understanding the compensation for injury process specific to the trial (25 vs. 51%; p < 0.0001). Modifications to the key information sheet in Study 2 did not affect likelihood of enrolling (88 vs. 85 vs. 85%; p = 0.6); however, understanding of randomization differed by form (44 vs. 59 vs. 46%; p = 0.002).

Conclusions
These findings suggest that refining consent forms to clarify key information and tailoring compensation for injury language to the nature of the study, especially in the context of comparative effectiveness trials, may help to improve study comprehension but may not impact enrollment.
Co-cultures of Propionibacterium freudenreichii and Bacillus amyloliquefaciens cooperatively upgrade sunflower seed milk to high levels of vitamin B12 and multiple co-benefits
Authors: Tangyu Muzi , Fritz Michel , Ye Lijuan , Aragão Börner Rosa , Morin-Rivron Delphine , Campos-Giménez Esther , Bolten Christoph J. , Bogicevic Biljana , Wittmann Christoph 
Published: March 2022

Abstract
Background
Sunflower seeds (Helianthus annuus) display an attractive source for the rapidly increasing market of plant-based human nutrition. Of particular interest are press cakes of the seeds, cheap residuals from sunflower oil manufacturing that offer attractive sustainability and economic benefits. Admittedly, sunflower seed milk, derived therefrom, suffers from limited nutritional value, undesired flavor, and the presence of indigestible sugars. Of specific relevance is the absence of vitamin B12. This vitamin is required for development and function of the central nervous system, healthy red blood cell formation, and DNA synthesis, and displays the most important micronutrient for vegans to be aware of. Here we evaluated the power of microbes to enrich sunflower seed milk nutritionally as well as in flavor.

Results
Propionibacterium freudenreichii NCC 1177 showed highest vitamin B12 production in sunflower seed milk out of a range of food-grade propionibacteria. Its growth and B12 production capacity, however, were limited by a lack of accessible carbon sources and stimulants of B12 biosynthesis in the plant milk. This was overcome by co-cultivation with Bacillus amyloliquefaciens NCC 156, which supplied lactate, amino acids, and vitamin B7 for growth of NCC 1177 plus vitamins B2 and B3, potentially supporting vitamin B12 production by the Propionibacterium. After several rounds of optimization, co-fermentation of ultra-high-temperature pre-treated sunflower seed milk by the two microbes, enabled the production of 17 µg (100 g)−1 vitamin B12 within four days without any further supplementation. The fermented milk further revealed significantly enriched levels of l-lysine, the most limiting essential amino acid, vitamin B3, vitamin B6, improved protein quality and flavor, and largely eliminated indigestible sugars.

Conclusion
The fermented sunflower seed milk, obtained by using two food-grade microbes without further supplementation, displays an attractive, clean-label product with a high level of vitamin B12 and multiple co-benefits. The secret of the successfully upgraded plant milk lies in the multifunctional cooperation of the two microbes, which were combined, based on their genetic potential and metabolic signatures found in mono-culture fermentations. This design by knowledge approach appears valuable for future development of plant-based milk products.