bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introduction
Authors: Stump Eleonore 
Published: February 2025

Abstract
There is a kind of knowledge that is non-propositional; one variety of it can be acquired in second-person experience of another person, but it can also be transmitted through narratives. This narratively mediated kind of knowledge can be significant for philosophical and theological reflection. Biblical narratives are specially fruitful in this regard, because they offer profound insights into the nature of the human condition and human flourishing. This book brings together detailed examinations of narratives in the Hebrew Bible and the New Testament to yield one large, emergent story which has something to teach that can be missed when the stories are taken in isolation from one another. These are the stories of Job, Samson, Abraham, Mary of Bethany, the temptations of Christ, the passion of Christ, and the story in the biblical book of Ecclesiastes. Taken together, these stories depict a possible world in which there is a good for suffering human beings that outweighs their suffering and that could not be gotten without the suffering, not even in a world without a Fall. On this emergent larger story, human suffering is defeated; and peace and joy in human life are possible.
The Story of Samson
Authors: Stump Eleonore 
Published: February 2025

Abstract
Samson is an exemplar of a person who suffers greatly but whose suffering stems from his own wrongdoing. This chapter focuses on the problem of suffering as regards not the victims of human evil but as regards the perpetrators of it, whose own lives are wrecked in consequence of the evil they do. The chapter concentrates on the biblical story of Samson and gives a detailed philosophical examination of many parts of the story. In the process, the chapter also explores Milton’s understanding of the story in his Samson Agonistes, as well as Sophocles’s portrayal of an analogous case in his Oedipus at Colonus. The chapter shows that in the story what redeems Samson’s suffering for him is the role of his suffering in bringing him into relationship with God.
Language conflicts
Authors: Coulmas Florian 
Published: February 2025

Abstract
This chapter concentrates on policy questions revolving around conflicts relating to language and their implications for access to power and political participation in democratic and authoritarian regimes. Taking ‘the age of language conflict’, a concept introduced by Max Weber, as point of departure, it explains how language became ever more politically important and often contentious in a world increasingly divided into nation states. The chapter portrays four state-language regimes in characteristically different settings of European and post-colonial nation building processes. Language-related conflicts and tensions in Belgium, Canada, Pakistan, and Yugoslavia and its follower states illustrate the success and failure of specific language policies.
Devils in Petticoats
Authors: Taylor James 
Published: February 2025

Abstract
Chapter 1 surveys evidence for women’s involvement in early financial markets, not only as providers of capital, but also as intermediaries, managing the investments of others, and navigating the nascent financial district. It explores how women’s financial agency was problematized in public discourse, especially in the wake of the South Sea Bubble of 1720, and how financial activity was increasingly understood in gendered and sexualized terms, with male speculators mastering a feminized market. This conceptual exclusion was matched by an institutional exclusion with the enclosure of the market represented by the establishment of the Stock Exchange. The chapter explores the culture of the Stock Exchange as it developed in the nineteenth century, and how this culture depended upon excluding women. It goes on to explore the evolving boundaries between acceptable and unacceptable financial behaviour for women in Victorian Britain. The passive provision of capital for low-risk investments and the passive receipt of male advice were accepted, but the idea that women should speculate, or could become active financial agents in their own right, was scorned.
Being a Female Stockbroker in Late Victorian and Edwardian Britain
Authors: Taylor James 
Published: February 2025

Abstract
Chapter 2 demonstrates how a flourishing market outside the London Stock Exchange made it possible for women to establish stockbroking businesses from the 1880s. It identifies ten women who were active between the 1880s and 1910s, and explores the conditions that made it possible for them to become brokers, including the influence of the pioneering Americans Victoria Woodhull and Tennessee Claflin. It examines the women’s backgrounds, the kinds of businesses they established, and the clients they sought to attract. Some, like Amy Bell, catered to women investors, and saw their purpose in educational as well as commercial terms. Others traded anonymously, not seeking to use their gender as part of their ‘sales pitch’. While some promoted the idea of cautious, low-risk investment, others aimed to capitalize on the late Victorian boom in ‘bucket shops’, which encouraged gambling on stock prices rather than long-term investment. Just as historians have rejected the idea that there was a single ‘type’ of female entrepreneur, so there was no sole way to be a female stockbroker in this period.
The Scattered Torah
Authors: Vidas Moulie 
Published: February 2025

Abstract
Amoraic discussions center on knowledge of rabbinic texts, but this knowledge is presented as fragmentary. Frequently occurring phrases and rhetorical structures highlight the discovery of old-new teachings while at the same time emphasizing that even the greatest scholars do not know pertinent teachings; the recognition that knowledge is subject to the contingencies of individual access and geography is employed in passages that explain that certain teachings resulted from limited access to texts. Rather than presenting these problems as limitations, Amoraic scholarship leveraged them as interpretive and rhetorical resources.
Nine Accounts of Manipulation
Authors: Noggle Robert 
Published: February 2025

Abstract
This chapter surveys several accounts of manipulation, to see how they stack up against the data set of paradigm examples of manipulation from Chapter 2. It argues that while most of them get something right about manipulation, they all face significant challenges. Some fail to identify manipulation in some of the paradigm examples; others imply that manipulation is present when it seems to be clearly absent. The chapter identifies two of the most promising accounts: one that sees manipulation as a form of trickery, akin to lying and deception, and one that sees it as a form of pressure that falls short of coercion. Each of these two accounts fails to identify manipulation in about half of the paradigm examples from Chapter 2. However, each one succeeds precisely where the other fails, so that these two accounts together properly identify manipulation in all the paradigm examples from Chapter 2.
Making Muslims Great Again
Authors: Barylo William 
Published: February 2025

Abstract
The alt-bros are a heterogeneous movement of Muslims openly against women’s rights, vocal against social justice movements, Black people, and, for some, supporting the far-right and embracing white supremacist language. With an allusion to the Red Pill symbol appropriated by men’s right activists and the alt-right, they fear the decline of Islam in Euro-America not because of racism and islamophobia but because of feminism, liberalism, and the LGBTQ. They revendicate an exclusionary form of Muslimness and masculinity, excommunicating anyone who does not abide by their standards. However, what if societal pressures and dominant expectations made these potential community champions turn sour? And what if, reading their story from the perspective of affect, one could see them like bell hooks, as ‘comrades in struggle’?
SCEMENT: Scalable and Memory Efficient Integration of Large-scale Single Cell RNA-sequencing Data
Authors: Chockalingam Sriram P , Aluru Maneesha , Aluru Srinivas 
Published: February 2025

Abstract

Motivation
Integrative analysis of large-scale single cell data collected from diverse cell populations promises an improved understanding of complex biological systems. While several algorithms have been developed for single cell RNA-sequencing data integration, many lack scalability to handle large numbers of datasets and/or millions of cells due to their memory and run time requirements. The few tools which can handle large data do so by reducing the computational burden through strategies such as subsampling of the data or selecting a reference dataset, to improve computational efficiency and scalability. Such shortcuts however hamper accuracy of downstream analyses, especially those requiring quantitative gene expression information.

Results
We present SCEMENT, a SCalablE and Memory-Efficient iNTegration method to overcome these limitations. Our new parallel algorithm builds upon and extends the linear regression model previously applied in ComBat, to an unsupervised sparse matrix setting to enable accurate integration of diverse and large collections of single cell RNA-sequencing data. Using tens to hundreds of real single cell RNA-seq datasets, we show that SCEMENT outperforms ComBat as well as FastIntegration and Scanorama in runtime (upto 214X faster) and memory usage (upto 17.5X less). It not only performs batch correction and integration of millions of cells in under 25 minutes, but also facilitates discovery of new rare cell-types and more robust reconstruction of gene regulatory networks with full quantitative gene expression information.

Availability and implementation
Source code freely available for download at https://github.com/AluruLab/scement, implemented in C ++ and supported on Linux.

Supplementary information
Supplementary data are available at Bioinformatics online.
SimMS: A GPU-Accelerated Cosine Similarity implementation for Tandem Mass Spectrometry
Authors: Onoprishvili Tornike , Yuan Jui-Hung , Petrov Kamen , Ingalalli Vijay , Khederlarian Lila , Leuchtenmuller Niklas , Chandra Sona , Duarte Aurelien , Bender Andreas , Gloaguen Yoann 
Published: February 2025

Abstract

Motivation
Untargeted metabolomics involves a large-scale comparison of the fragmentation pattern of a mass spectrum against a database containing known spectra. Given the number of comparisons involved, this step can be time-consuming.

Results
In this work, we present a GPU-accelerated cosine similarity implementation for Tandem Mass Spectrometry (MS), with an approximately 1000-fold speedup compared to the MatchMS reference implementation, without any loss of accuracy. This improvement enables repository-scale spectral library matching for compound identification without the need for large compute clusters. This impact extends to any spectral comparison-based methods such as molecular networking approaches and analogue search.

Availability
All code, results, and notebooks supporting are freely available under the MIT license at https://github.com/pangeAI/simms/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Formation of biobased-polycarbonates via amorphous solid-state polymerization of isosorbide/isomannide with fluorinated carbonate
Authors: Taniguchi Taihei , Okazoe Takashi , Matsuoka Shin-ichi , Suzuki Masato 
Published: February 2025

Abstract
Polycarbonates (PC) derived from bio-derived diol monomers, isosorbide (ISB) and isomannide (IMN), are attractive alternatives to bisphenol A (BPA) PCs owing to their fused-bicyclic main chain structures. However, conventional solid-state polymerization (SSP) of amorphous polycarbonates requires crystallization of the monomers or oligomeric prepolymers. Previously, we disclosed the amorphous SSP of BPA with bis(1,1,1,3,3,3-hexafluoro-2-propyl) carbonate (BHFC), which efficiently synthesizes high-molecular-weight PCs. Here, we present the first synthesis of biobased PCs via amorphous SSP of a prepolymer prepared from ISB/IMN with BHFC. During the SSP, the reaction temperature was increased stepwise to 170°C, affording moderate- to high-molecular-weight poly(ISB carbonate)s and poly(ISB/IMN carbonate)s. Increasing the feed ratio decreased the molecular weight of the poly(ISB/IMN carbonate) copolymer. We also combined IMN with the bis(hexafluoroisopropyl carbonate) of IMN (IMNBFC) to obtain poly(IMN carbonate). Furthermore, ISB combined with IMNBFC afforded a copolymer consisting of alternating ISB and IMN units. No crystalline structures were observed during any SSP process or the resulting PCs. The PCs achieved satisfactorily high thermal stabilities, high glass transition temperatures, and low discoloration because the SSP was performed at lower temperatures than conventional melt polymerization.
Photocatalytic CO2 reduction in aqueous media using a silver-loaded conjugated polymer and a Ru(II)-Ru(II) supramolecular photocatalyst
Authors: Sakakibara Noritaka , McQueen Ewan , Sprick Reiner Sebastian , Ishitani Osamu 
Published: February 2025

Abstract
Visible-light-driven conversion of CO2 to useful products is a promising process for a more sustainable energy system in a circular economy. Whilst highly efficient, durable and selective systems have been reported in organic media, the photocatalytic process performing efficiently in aqueous media is highly desirable for the purpose of its practical application. However, efficiency and selectivity for CO2 reduction versus proton reduction in aqueous solution has proven challenging to date. Herein, this study demonstrates the enablement of highly efficient and durable visible-light driven photocatalytic CO2 reduction to formate in aqueous media by a hybrid photocatalyst consisting of a silver-loaded conjugated polymer and a binuclear Ru(II) complex. The hybrid photocatalyst exhibited high activity and durability for formate production, with an apparent quantum yield of 4.2% at 460 nm and a turnover number of 38,000 (based on the amount of binuclear complexes adsorbed), both of which are the highest values reported amongst hybrid photocatalysts in aqueous media. Even though the conjugated polymer retains residual amounts of palladium from synthesis (which is an active site for H2 production in aqueous media), the loading of Ag nanoparticles onto the conjugated polymer enhanced the activity and selectivity for photocatalytic CO2 reduction by suppressing H2 production.
TNBC molecular subtypes and potential detection targets for biological therapy indications
Authors: Zhang Yanchuan , Li Qinghua , Lan Jie , Xie Guojing , Zhang Guangjie , Cui Junhao , Leng Ping , Wang Yingshuang 
Published: February 2025

Abstract
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer associated with poor prognosis. While chemotherapy remains the conventional treatment approach, its efficacy is limited and often accompanied by significant toxicity. Advances in precision-targeted therapies have expanded treatment options for TNBC, including immunotherapy, poly (ADP-ribose) polymerase inhibitors, androgen receptor inhibitors, cell cycle-dependent kinase inhibitors, and signaling pathway inhibitors. However, the heterogeneous nature of TNBC contributes to variations in treatment outcomes, underscoring the importance of identifying intrinsic molecular subtypes for personalized therapy. Additionally, due to patient-specific variability, the therapeutic response to targeted treatments is inconsistent. This highlights the need to strategize patients based on potential therapeutic targets for targeted drugs to optimize treatment strategies. This review summarizes the classification strategies and immunohistochemical (IHC) biomarkers for TNBC subtypes, along with potential targets for identifying indications for targeted drug therapy. These insights aim to support the development of personalized treatment approaches for TNBC patients.
Molecularly imprinted polymer for solid-phase extraction of oleanolic acid from Ligustrum lucidum fruit
Authors: Xu Jianling , Wang Wenna , Chen Yixin , Xu Xiaotian , Duan Ao , Zhu Yongyan , Zhu Quanhong 
Published: February 2025

Abstract
A molecularly imprinted polymer (MIP) was synthesized for the selective extraction of oleanolic acid (OA), employing OA as the template molecule, acrylamide as the functional monomer, ethylene glycol dimethacrylate as the cross-linking agent, azobisisobutyronitrile as the initiator, and chloroform as the porogenic solvent. The characterization of the obtained MIPs was evaluated by scanning electron microscopy, Fourier transform infrared spectroscopy, Brunauer–Emmett–Teller (BET) analysis and X-ray photoelectron spectroscopy. The MIPs reached adsorption equilibrium within 2 hours to OA, with high adsorption capacity of 124.68 mg/g. Subsequently, these MIPs were packed in empty solid-phase extraction (SPE) cartridge to enrichment OA from Ligustrum lucidum fruit extract. The parameters of SPE were optimized as follows: loading 0.5 ml of a 1.0 mg/ml OA reference solution, washing with 0.5 ml of toluene, and eluting with 4 ml of methanol. Under these conditions, the enrichment rate of OA from L. lucidum extract reached 76.0%. Additionally, an high-performance liquid chromatography method for determining OA content was validated. This study provides an effective approach for the separation and enrichment of OA from complex matrices and also provides practical feasibility for the separation and enrichment of other triterpenoids.
The Effectiveness of Newer Beta-Lactams for the Treatment of Antimicrobial-Resistant Gram-Negative Meningitis
Authors: Hsu Alice J , Chiotos Kathleen , Heil Emily L , Shields Ryan K , Tamma Pranita D 
Published: February 2025

Abstract
The treatment of gram-negative bacterial infections exhibiting resistance to all traditional β-lactam and fluoroquinolone agents (i.e., difficult-to-treat resistance [DTR]) poses challenges due to the limited numbers of active antibiotic agents, in addition to limited data on safety and efficacy. Managing DTR gram-negative infections becomes even more complex when present in the central nervous system due to concerns for insufficient concentrations of agents in the cerebrospinal fluid and brain parenchyma. Several newer β-lactam agents with activity against DTR gram-negatives are available including cefiderocol, ceftazidime-avibactam, ceftolozane-tazobactam, imipenem-cilastatin-relebactam, meropenem-vaborbactam, and sulbactam-durlobactam. In this article, we review host and drug factors that influence an antibiotic’s likely effectiveness for the treatment of bacterial meningitis. We also review the preclinical and clinical data in support of or against each of the aforementioned agents for the treatment of bacterial meningitis.
Entropic detection of chromatic community structures
Authors: Delaplace Franck 
Published: February 2025

Abstract
The identification of community structure represents a central challenge in the field of complex networks. The objective is to ascertain the internal organization of agents within a network and to provide a representative network partition. Each community is presumed to comprise nodes sharing a common objective or property. The identification of these communities is typically based on the difference in connectivity density between the interior and border of a community. Indeed, nodes sharing a common purpose or property are expected to interact closely. Although this rule appears to be relevant, it nevertheless fails to address fundamental scientific problems such as disease module detection, thereby highlighting the inability to meaningfully determine communities based solely on connectivity for this situation. Consequently, another paradigm is necessary to formalize this problem accurately and detect these communities objectively. In this article, we propose a new framework to study this novel community formation property. Considering that colors represent shared properties, the problem is to maximize groups of nodes of the same color within communities. We propose a novel algorithm for detecting community structure based on a new measurement, chromatic entropy, which quantitatively assesses the community structure based on color constraint.
Sex Steroid Hormones and Subclinical Atherosclerosis Progression in Postmenopausal Women
Authors: Chen Irene J , Stanczyk Frank Z , Sriprasert Intira , Karim Roksana , Shoupe Donna , Kono Naoko , Hodis Howard N , Mack Wendy J 
Published: February 2025

Abstract

Objective
The Early versus Late Intervention Trial with Estradiol demonstrated that hormone therapy (HT) reduces subclinical atherosclerosis progression in healthy postmenopausal women who initiated HT in proximity to menopause (&lt;6 years) but not in those distant from menopause, (≥10 years). This analysis explores the role of serum sex steroid hormones and sex hormone-binding globulin (SHBG) in atherosclerosis progression, examining differences based on time since menopause.

Design
Post-trial analysis.

Methods
The study included 535 healthy postmenopausal women; nearly half received HT. Serum levels of estradiol, estrone, testosterone, and SHBG were measured at baseline, 12 months, and 36 months. Carotid intima-media thickness (CIMT) was assessed every six months. Mixed-effects linear models evaluate the relationship between sex steroid hormones, SHBG, and CIMT progression, with time since menopause included as an interaction term, after adjusting for age, hysterectomy, baseline CIMT, systolic blood pressure, and body mass index.

Results
Late postmenopausal women were older with higher baseline CIMT. Associations between estradiol, estrone, and SHBG levels with CIMT progression differed significantly by time since menopause (interaction p &lt; 0.01). In early postmenopause, CIMT progression was significantly inversely associated with SHBG (p = 0.024) and nonsignificantly inversely with estradiol and estrone. In late postmenopause, CIMT progression was significantly positively associated with estradiol (p = 0.005), estrone (p &lt; 0.001), and SHBG (p = 0.037).

Conclusion
Serum sex steroid hormones and SHBG relate differently to CIMT progression based on time since menopause. Estradiol, estrone, and SHBG levels show opposite associations with CIMT progression in early versus late postmenopause, highlighting the importance of HT timing in cardiovascular disease.