bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Indeks Massa Tubuh (Imt) Dengan Kejadian Dismenorea Di Kabupaten Bulukumba
Authors: Uni Jusni , Akhfar Kurniati , Arfi Arfiani , Khaera Nadiatul 
Published: October 2022

Masa remaja merupakan masa yang kritis dalam siklus kehidupan manusia. pada masa ini, remaja mengalami perubahan, Salah satu perubahan pada remaja putri ketika menuju dewasa adalah terjadinya menstruasi. Meskipun menstruasi ialah proses alamiah yang dialami oleh perempuan. Namun saat menstruasi dapat terjadi beberapa gangguan menstruasi. Salah satu gangguan yang terjadi saat menstruasi yang menyebabkan ketidaknyamanan fisik yaitu nyeri haid atau dismenorea. Berdasarkan data WHO (world health organization) angka kejadian dismenorea di dunia sangat besar rata rata dari 50% perempuan disetiap negara mengalami nyeri haid. Menurut penelitian Lestari dkk (2018), prevalensi dismenore di Indonesia sebesar 64,25%, terdiri dari dismenore primer sebesar 54,89% dan 9,36% mengalami dismenore sekunder. Salah satunya penyebab terjadinya dismenorea adalah status gizi. Status gizi seseorang dapat diukur menggunakan Indeks Massa Tubuh. Penelitian ini bertujuan untuk mengetahui hubungan antara indeks massa tubuh dengan kejadian dismenore di Kabupaten Bulukumba. Desain penelitian adalah deskriptif cross-sectional dengan uji chi square. Populasi adalah mahasiswi Akademi Kebidanan Tahirah Al Baeti Bulukumba kabupaten Bulukumba, dengan 48 sampel menggunakan total sampling. Hasil penelitian analisis univariat didapatkan bahwa indeks massa tubuh dengan kategori normal 64.6%, 35.4% yang indeks massa tubuh tidak normal, yang mengalami dismenorea sebanyak 54.2% sedangkan yang tidak mengalami dismenorea 45.8%. Dengan Menggunakan uji chi square menunjukkan ada hubungan antara indeks massa tubuh dengan kejadian dismenorea (p=0,001).Kesimpulan dalam penelitian ini menunjukkan bahwa dismenorea lebih banyak didapatkan pada indeks massa tubuh tidak normal yang berada diklasifikasi underweight,overweight dan obesitas dengan jumlah 15 mahasiswa (88.2%) sedangkan indeks massa tubuh normal normal yang mengalami dismenorea terdapat 11 mahasiswa (35.5%). Setelah dilakukan uji chi square didapatkan nilai p=0,001 yang berarti ada hubungan antara indeks massa tubuh dengan dismenorea.
Pengaruh Kepemilikan Kas, Rencana Bonus, Risiko Keuangan, Nilai Perusahaan Dan Ukuran Perusahaan Terhadap Perataan Laba (Studi Kasus Pada Perusahaan Subsektor Perkebunan Yang Terdaftar Di Bursa Efek Indonesia Tahun 2012-2020)
Authors: Rismaya Rina 
Published: October 2022

Penelitian ini merupakan studi pustaka terhadap menejemen keuangan. Penelitian ini bertujuan untuk mendeskipsikan dan menganalisis kembali pengaruh kepemilikan kas,rencana bonus,resiko keuangan. Metode penelitian yang digunakan dalam penelitian ini adalah metode deskriptif dan verifikatif. Metode deskiptif adalah metode yang di gunakan untuk meneliti dan menganalisis sustu hasil penelitian.dan metode verivikatif menurut sugiono adalah penelitian yang menguji teori dan mengujian hipotesis. Hasil penelitian menyimpulkan agar bisa memverifikasi kebenaran dan hasil penelitian tersebut. Dan resiko keuangan berpengaruh positif terhadap perataan laba dan hal ini menunjukan bahwa semakin tinggi resiko keuangan maka semakin tinggi praktik perataan laba dan sebaliknya semakin rendah resiko keuangan maka semakin rendah praktik perataan laba.
Peranan Kepala Desa dalam Pemberdayaan Masyarakat di Desa Teteinea Kecamatan Lalembuu Kabupaten Konawe Selatan
Authors: Jawiah St. 
Published: October 2022

Tujuan dari penelitian ini untuk mengetahui peranan Kepala Desa dalam pemberdayaan masyarakat di Desa dan mengetahui faktor-faktor apa yang mempengaruhi peranan Kepala Desa dalam pemberdayaan masyarakat di Desa Teteinea Kecamatan Lalembuu Kabupaten Konawe Selatan. Teknik analisis data yang digunakan dalam penelitian ini adalah deskriptif-kualitatif, yakni semua data yang diperoleh dilapangan dikumpulkan dan kemudian ditarik kesimpulan berdasarkan jawaban-jawaban yang relevan dengan masalah-masalah dalam penelitian ini. Hasil Penelitian diantaranya yaitu pertama, Peranan Kepala Desa dalam pemberdayaan masyarakat secara umum sudah memberikan perubahan dan pembangunan serta pelatihan kepada masyarakat sesuai tuntutan pekerjaannya sudah baik. Kedua, Adapun peranan Kepala Desa baik dalam perencanaan, pelaksanaan dan pengawasan secara keseluruhan dinyatakan berperan aktif sebagai seorang Kepala Desa dalam ketiga kategori tadi, namun di bagian perencanaan mendapat sedikit hambatan karena kurangnya partisipasi masyarakat untuk ikut serta dalam sosialisasi program yang akan dilaksanakan. Kemudian masalah yang dihadapi Kepala Desa dalam pelaksanaan program yaitu seperti hujan, kerusakan alat berat dan sedikit tenaga kerja yang menjadi kendala utama seperti pembuatan jalan tani dan drainase.
Pengaruh Metode Pancing Kata Kunci terhadap Kemampuan Menulis Puisi Berbantuan Media Karikatur pada Kelas X
Authors: Mar’ah Maghfirotul , Devi Wika Soviana 
Published: October 2022

Melihat masih rendahnya kemampuan dalam menulis puisi di kalangan siswa, untuk itu kegiatan pembelajaran tersebut harus mempergunakan salah satu teknik pembelajaran yang menyenangkan dan menarik untuk siswa yakni dengan memakai media gambar karikatur. Pemakaian media yang sesuai akan membuat siswa mudah mengerti dalam mengerti materi puisi yang diterangkan guru di sekolah. Penelitian ini bertujuan untuk mengetahui cara meningkatkan keterampilan menulis puisi dan mengetahui pengaruh teknik pancingan kata kunci berbantuan media karikatur dalam kemampuan menulis puisi siswa kelas X. Penelitian ini menggunakan metode kuantitatif dengan pendekatan eksperimen. Populasi yang dipilih oleh peneliti yaitu kelas X MA Islamiyah Ciputat tahun ajaran 2021/2022 dengan jumlah 50. Adapun sampel ini dilakukan dengan cara simple random sampling. Hasil penelitian menunjukkan bahwa kelompok eksperimen mempunyai perbedaan skor yang bermakna dibanding kelompok kontrol. Hasil skor tertinggi adalah 40% dengan rentang 65-79 pada kelas eksperimen, sedangkan pada kelas kontrol 30% pada rentang 23-32. Pada pembelajaran di kelas eksperimen, keterampilan menulis puisi menerapkan media gambar lebih efektif daripada tidak mempergunakan media gambar untuk siswa kelas X MA Islamiyah Ciputat.
Penggunaan Model Pembelajaran Two Stay Two Stray untuk Meningkatkan Keaktifan Peserta Didik pada Pembelajaran Sejarah di Kelas XII MIPA 1 SMAN 2 Pekanbaru
Authors: Alfiqri Yanuar , Indayani Wiwen 
Published: October 2022

Artikel ini merupakan suatu karya ilmiah sederhana mengenai pembelajaran Sejarah. Penelitian ini menggunakan metode Penelitian Kuantitatif. Bertujuan guna mengetahui penggunaan model Two Stay Two Stray untuk meningkatkan keaktifan peserta didik pada pembelajaran sejarah. Dalam pembelajaran sejarah dibutuhkannya model untuk mempermudah pemahaman siswa yang mana selama ini pembelajaran Sejarah banyak menggunakan metode ceramah dan hafalan saja. Maka diperlukannya sebuah model baru yang akan membuat peserta didik dapat lebih memahami materi yang disampaikan dan dapat mengaplikasikannya dalam kehidupan sehari-hari. Penelitian ini dilaksanakan di SMA N 2 Pekanbaru dengan subjeknya adalah siswa siswi kelas XII. Adapun hasil dari penelitian ini menunjukkan bahwasannya siswa-siswi kelas XII sangat antusias, aktif dan sangat komunikatif dalam mengikuti proses pembelajaran ketika menggunakan model pembelajaran Two Stay Two Stray pada saat belajar, berbeda saat hanya menggunakan metode ceramah, mereka cenderung lebih pasif, dari sini peneliti melihat bahwa penelitian yang di lakukan bisa dikatakan berhasil.
Pengaruh Fasilitas Belajar terhadap Prestasi Belajar Siswa Mata Pelajaran IPS
Authors: Sapriani Ani , Supriyadi  
Published: October 2022

Fasilitas belajar merupakan salah satu faktor yang mempengaruhi prestasi belajar. Tujuan penelitian ini untuk mengungkapkan fasilitas belajar (X) prestasi belajar (Y). Penelitian ini penelitian kuantitatif dengan pendekatan survei. Sampel penelitian menggunakan tehnik random sampling. Jumlah sample penelitian sebanyak 52 siswa. Pengambilan data menggunakan instrumen yang valid dan reliabel. Analisis menggunakan regresi sederhana, hasil penelitian ini mengungkapkan: (1) Persamaan Regresi Linear Y = 66,493 + 0,146 X. (2) Fasilitas belajar berpengaruh positif terhadap prestasi belajar IPS (Ekonomi) siwa kelas X SMK. (3) Uji Signifikansi persamaan garis regresi Fhit 0,571 dan p-value = 0,453 > 0,05 dengan demikian regresi Y atau X adalah signifikan atau pengaruh fasilitas terhadap prestasi belajar siswa mata pelajaran IPS. (4) Koefisien kolerasi (rxy) = 0,106 dan Fhit (Fchange) = 0,571, dengan p-value = 0,453 > 0,05. Dengan demikian keofisien kolerasi X dan Y yang berarti Signifikan.
A TIPIFICAÇÃO DOS CRIMES CONTRA A HUMANIDADE NO DIREITO BRASILEIRO: A REALIZAÇÃO DE DISTINGUISHING E OVERRULING EM RELAÇÃO AO ATUAL PARADIGMA JURISPRUDENCIAL
Authors: Oliveira Lucas Paulo Orlando de , Saldanha Jânia Maria Lopes 
Published: October 2022

O objetivo do presente artigo é identificar elementos para a realização do distinguishing em relação à atual jurisprudência do Supremo Tribunal Federal (STF) e Superior Tribunal de Justiça (STJ) quanto à incidência na ordem jurídica nacional do art. 7º do Estatuto de Roma, que tipifica as condutas consideradas como crimes contra a humanidade. O Estudo se situa na área do Direito Internacional Penal e segue à Metodologia de Análise de Decisões. Há a divisão em duas partes. Na primeira, analisam-se decisões no âmbito do STF e STJ a respeito da incidência dos tipos penais previstos em tratados internacionais no direito brasileiro. Na segunda, pretende-se a distinção da atual posição, que é pela não-incidência da tipificação dos crimes contra a humanidade prevista pelo Estatuto de Roma. São apresentados seis fundamentos para evidenciar a distinção necessária em relação à ratio decidendi do paradigma atual. À guisa de conclusão, propõe-se o overruling do Informativo Jurisprudencial 659 do STJ, de modo a reconhecer a incidência do tipo penal a respeito dos crimes de Lesa Humanidade no direito brasileiro, independentemente de legislação específica superveniente à ratificação.
Impact and Assessment of Frontline Demonstration (FLD) Management of Weeds in Pineapple by Plastic Mulch
Authors: Shukla Rohit , Hnamte Vanlalhruaia , Kumar Santosh , Pandey Nitin Kumar 
Published: October 2022

Twenty-five numbers of frontline demonstrations were conducted on management of weed in pineapple by plastic mulch 2014-2016 & 2016-2018 subsequently with an ultimate aim to supressed growth of weeds and boost farmer income because weeding accounts approximate 30–40% of the overall cost of crop. Pineapple cultivation with 50 micron black polythene sheet mulching with double row spacing i.e. 90 x 60 x 30cm not only suppresses the weed growth but conserves the soil moisture, which leads to early flowering, better vegetative growth & higher yield over control (Farmer practice). The demonstrated recorded an average yield ranging from 43.18 to 45.90 t/ha with a mean of 44.54 t/ha. The per cent increase yield in demonstration 49.77% during 2014-16 and 66.67% during 2016-18 respectively, over the farmer practice. The average ranges of extension gap (14.35- 18.36 t/ha), technology gap (9.10- 11.82 t/ha) and technology index (21.49-16.55%) were during the period under study. The demonstrated field gave higher mean gross return (Rs. 267240 /ha) and mean net returns (Rs. 191740/ha) with average benefit: cost ratio (3.54) compared to the local checks (1.71). Present results clearly show that the yield and economics of pineapple can be boost up by adoption of recommended technology.
Contour similarity and its implication on inverse prostate SBRT treatment planning
Authors: Yan Chenyu , Guo Bingqi , Tendulkar Rahul , Xia Ping 
Published: October 2022

AbstractPurposeSuccess of auto‐segmentation is measured by the similarity between auto and manual contours that is often quantified by Dice coefficient (DC). The dosimetric impact of contour variability on inverse planning has been rarely reported. The main aim of this study is to investigate whether automatically generated organs‐at‐risk (OARs) could be used in inverse prostate stereotactic body radiation therapy (SBRT) planning and whether the dosimetric parameters are still clinically acceptable after radiation oncologists modify the OARs.Methods and materialsPlanning computed tomography images from 10 patients treated with SBRT for prostate cancer were selected and automatically segmented by commercially available atlas‐based software. The automatically generated OAR contours were compared with the manually drawn contours. Two volumetric modulated arc therapy (VMAT) plans, autoRec‐VMAT (where only automatically generated rectums were used in optimization) and autoAll‐VMAT (where automatically generated OARs were used in inverse optimization) were generated. Dosimetric parameters based on the manually drawn PTV and OARs were compared with the clinically approved plans.ResultsThe DCs for the rectum contours varied from 0.55 to 0.74 with a mean value of 0.665. Differences ofD95of the PTV between autoRec‐VMAT and manu‐VMAT plans varied from 0.03% to −2.85% with a mean value of −0.64%. Differences ofD0.03ccof manual rectum between the two plans varied from −0.86% to 9.94% with a mean value of 2.71%.D95of PTV between autoAll‐VMAT and manu‐VMAT plans varied from 0.28% to −2.9% with a mean value −0.83%. Differences ofD0.03ccof manual rectum between the two plans varied from −0.76% to 6.72% with a mean value of 2.62%.ConclusionOur study implies that it is possible to use unedited automatically generated OARs to perform initial inverse prostate SBRT planning. After radiation oncologists modify/approve the OARs, the plan qualities based on the manually drawn OARs are still clinically acceptable, and a re‐optimization may not be needed.
A potential biomarker of cognitive impairment: The olfactory dysfunction and its genes expression
Authors: Song Jiayi , Xu Jiahui , Yuan Wei , Li Ruixue , Guo Hui , Gao Hanshu , Gu Cuiying , Feng Wenjing , Ma Yanan , Guo Haiqiang , Sun Zhaoqing , Zheng Liqiang 
Published: October 2022

AbstractObjectiveAccumulation evidence has reported that olfactory impairment may be an essential clinical marker and predictor of mild cognitive impairment or Alzheimer's disease.MethodParticipants were enrolled in the population‐based, prospective study in Fuxin county, Liaoning province, China between 2019 and 2021. An inverse probability weighting logistic regression and mixed‐effect models were performed to explore the association between dysosmia and cognition and rate of change in cognition, respectively. Besides, we utilized the Robust Rank Aggregation method to integrated three eligible datasets from the Gene Expression Omnibus to identify differential expressed genes.ResultsA total of 4695 participants were enrolled and 4221 of those were eligible for our cross‐sectional study. The mean (SD) age was 59.93(9.78) years, 64.8% were men. Over a 2‐year follow‐up, of the 2088 participants who completed follow‐up, 1559 participants were eligible for our longitude cohort study. We observed an association between dysosmia and an increased risk of cognitive impairment (OR, 0.47, [95% CI, 0.35–0.64]; p < 0.001). The OR (95% CI) for cognition in females with dysosmia was higher than (OR, 0.73[0.51, 1.05], p = .007) that for males with dysosmia (OR, 0.25[0.15, 0.42], p < 0.001; P for interaction <0.001). Dysosmia was also associated with more rapid decline in calculation ability (p < 0.001). Besides, several DEGs were identified, which are mainly associated with olfactory transduction, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, olfactory receptor activity and odorant binding.InterpretationThese findings proved novel insight into identifying olfactory dysfunction as potential biomarker for diagnosis of cognitive impairment.
Antibody–Antimicrobial Conjugates for Combating Antibiotic Resistance
Authors: Yu Luofeng , Shang Zifang , Jin Qizhe , Chan Siew Yin , Hong Weilin , Li Nan , Li Peng 
Published: October 2022

AbstractAs the development of new antibiotics lags far behind the emergence of drug‐resistant bacteria, alternative strategies to resolve this dilemma are urgently required. Antibody‐drug conjugate is a promising therapeutic platform to delivering cytotoxic payloads precisely to target cells for efficient disease treatment. Antibody–antimicrobial conjugates (AACs) have recently attracted considerable interest from researchers as they can target bacteria in the target sites and improve the effectiveness of drugs (i.e., reduced drug dosage and adverse effects), abating the upsurge of antimicrobial resistance. In this review, the selection and progress of three essential blocks that compose the AACs: antibodies, antimicrobial payloads, and linkers are discussed. The commonly used conjugation strategies and the latest applications of AACs in recent years are also summarized. The challenges and opportunities of this booming technology are also discussed at the end of this review.
Large Magneto‐Transverse and Longitudinal Thermoelectric Effects in the Magnetic Weyl Semimetal TbPtBi
Authors: Wang Honghui , Zhou Zizhen , Ying Jianjun , Xiang Ziji , Wang Rui , Wang Aifeng , Chai Yisheng , He Mingquan , Lu Xu , Han Guang , Pan Yu , Wang Guoyu , Zhou Xiaoyuan , Chen Xianhui 
Published: October 2022

AbstractMagnetic topological semimetals provide new opportunities for power generation and solid‐state cooling based on thermoelectric (TE) effect. The interplay between magnetism and nontrivial band topology prompts the magnetic topological semimetals to yield strong transverse TE effect, while the longitudinal TE performance is usually poor. Herein, it is demonstrated that the magnetic Weyl semimetal TbPtBi has high value for both transverse and longitudinal thermopower with large power factor (PF). At 300 K and 13.5 Tesla, the transverse thermopower and PF reach up to 214 µV K−1 and 35 µW cm−1 K−2, respectively, which are comparable to those of state‐of‐the‐art TE materials. Combining first‐principles calculations, longitudinal magnetoresistance and planar Hall resistance measurements, and two‐band model fitting, the large transverse thermopower and PF are attributed to both bipolar effect and large Hall angle. Moreover, the imperfectly compensated charge carriers and large transverse magnetoresistance induce the maximum magneto‐longitudinal thermopower of 251 µV K−1 with a PF of 24 µW cm−1 K−2 at 150 K and 13.5 Tesla, which is two times higher than that at zero magnetic field. This work demonstrates the great potential of topological semimetals for TEs and offers a new excellent candidate for magneto‐TEs.
Atomically Flat, 2D Edge‐Directed Self‐Assembly of Block Copolymers
Authors: Kim Jang Hwan , Jeong Hyeon U , Yeom Hye‐In , Han Kyu Hyo , Yang Geon Gug , Choi Hee jae , Kim Jong Min , Park Sang‐Hee Ko , Jin Hyeong Min , Kim Jaeup U. , Kim Sang Ouk 
Published: October 2022

AbstractNanoscale shape engineering is an essential requirement for the practical use of 2D materials, aiming at precisely customizing optimal structures and properties. In this work, sub‐10‐nm‐scale block copolymer (BCP) self‐assembled nanopatterns finely aligned along the atomic edge of 2D flakes, including graphene, MoS2, and h‐BN, are exploited for reliable nanopatterning of 2D materials. The underlying mechanism for the alignment of the self‐assembled nanodomains is elucidated based on the wetting layer alternation of the BCP film in the presence of intermediate 2D flakes. The resultant highly aligned nanocylinder templates with remarkably low levels of line edge roughness (LER) and line‐width roughness (LWR) yield a sub‐10‐nm‐wide graphene nanoribbon (GNR) array with noticeable switching characteristics (on‐to‐off ratio up to ≈6 × 104).
Fluorination Enhances NIR‐II Emission and Photothermal Conversion Efficiency of Phototheranostic Agents for Imaging‐Guided Cancer Therapy
Authors: Li Chunbin , Jiang Guoyu , Yu Jia , Ji Weiwei , Liu Lingxiu , Zhang Pengfei , Du Jian , Zhan Chuanlang , Wang Jianguo , Tang Ben Zhong 
Published: October 2022

AbstractPhototheranostics with second near‐infrared (NIR‐II) imaging and photothermal effect have become a burgeoning biotechnology for tumor diagnosis and precise treatment. As important parameters of phototheranostic agents (PTAs), fluorescence quantum yield (QY) and photothermal conversion efficiency (PCE) are usually considered as a pair of contradictions that is difficult to be simultaneously enhanced. Herein, a fluorination strategy for designing A–D–A type PTAs with synchronously improved QY and PCE is proposed. Experimental results show that the molar extinction coefficient (ε), NIR‐II QY, and PCE of all fluorinated PTAs nanoparticles (NPs) are definitely improved compared with the chlorinated counterparts. Theoretical calculation results demonstrate that fluorination can maximize the electrostatic potential difference by virtue of the high electronegativity of fluorine, which may increase intra/intermolecular D–A interactions, tighten molecule packing, and further promote the increase of ε, ultimately leading to simultaneously enhanced QY and PCE. In these PTA NPs, FY6‐NPs display NIR‐II emission extended to 1400 nm with the highest NIR‐II QY (4.2%) and PCE (80%). These features make FY6‐NPs perform well in high‐resolution imaging of vasculature and NIR‐II imaging‐guided photothermal therapy (PTT) of tumors. This study develops a valuable guideline for constructing NIR‐II organic PTAs with high performance.
Cerebral Malaria and Neuronal Implications ofPlasmodium FalciparumInfection: From Mechanisms to Advanced Models
Authors: Akide Ndunge Oscar Bate , Kilian Nicole , Salman Mootaz M. 
Published: October 2022

AbstractReorganization of host red blood cells by the malaria parasitePlasmodium falciparumenables their sequestration via attachment to the microvasculature. This artificially increases the dwelling time of the infected red blood cells within inner organs such as the brain, which can lead to cerebral malaria. Cerebral malaria is the deadliest complication patients infected withP. falciparumcan experience and still remains a major public health concern despite effective antimalarial therapies. Here, the current understanding of the effect ofP. falciparumcytoadherence and their secreted proteins on structural features of the human blood‐brain barrier and their involvement in the pathogenesis of cerebral malaria are highlighted. Advanced 2D and 3D in vitro models are further assessed to study this devastating interaction between parasite and host. A better understanding of the molecular mechanisms leading to neuronal and cognitive deficits in cerebral malaria will be pivotal in devising new strategies to treat and prevent blood‐brain barrier dysfunction and subsequent neurological damage in patients with cerebral malaria.