bluuebunny/crossref_metadata_2025_split huggingface dataset:
EKSISTENSI INDONESIA SEBAGAI ANGGOTA TIDAK TETAP DEWAN KEAMANAN PBB DALAM MEWUJUDKAN PERDAMAIAN DAN KEAMANAN INTERNASIONAL
Authors: Adwani Adwani 
Published: July 2022

Indonesia dengan politik luar negeri yang bebas dan aktif memiliki peran penting untuk mewujudkan kepentingan Negara Indonesia dan kepentingan dunia internasional yang diperankan dalam furum PBB dan DK PBB sehubungan dengan bermacam persoalan internasional yang terjadi, seperti politik, hukum dan keamanan internasional. Indonesia telah berkontribusi, namun keefektifannya perlu diperhatikan untuk peningkatannya. Penulisan ini dimaksudkan untuk mengetahui bagaimana kontribusi aktif yang telah dijalankan Indonesia tersebut telah membawa hasil yang efektif dan optimal bagi kepentingan masyarakat internasional, seperti persoalan yang terjadi di kawasan Timur Tengah dan Asia. Berkenaan dengan eksistensi Indonesia di D K PBB sebagai anggota tidak tetap, ternyata Indonesia telah berperan aktif dan memberikan kontribusi bagi kepentingan bersama, termasuk perdamaian dan keamanan dunia, seperti persoalan politik dan hak asasi manusia, pendelegasian perempuan dan isu keamanan kawasan. Dalam kaitan tersebut Indonesia telah berperan dalam mencari solusi, seperti terhadap konflik bersenjata di Timur Tengah, masalah Palestina dan berkenaan dengan hak asasi manusia di Rohingnya Myanmar, perdamaian Filipina, termasuk persoalan konflik Rusia dengan Ukraina. Namun demikian keefektifan dan optimalisasi kontribusi Indonesia sangat perlu ditingkatkan di forum internasional guna lebih berkontribusi lagi ke depan
INTEGRASI HUKUM ADAT DALAM HUKUM PERKAWINAN DI INDONESIA
Authors: Muzakkir  
Published: July 2022

Studi ini mengkaji tentang integrasi hukum adat dalam hukum perkawinan di indonesia (analisis UU no. 1 Tahun 1974 dan KHI Indonesia). Dari hasil kajian didapati hasil bahwa aturan adat dan aturan Islam memiliki hubungan, yaitu mempunyai kedudukan atau fungsi yang sama. Kedua aturan tersebut saling melengkapi tanpa harus menghilangkan sedikitpun identitas masing-masing dari kedua aturan tersebut. Sebagai sebuah kesatuan lembaga sosial, aturan adat dan aturan Islam akan berinteraksi dalam kehidupan akan didukung oleh masyarakat atau penganut ajarannya. Dalam perjalananya seorang hakim yang tidak mampu menemukan sebuah pasal pun pada UU No. 1 Tahun 1974 maka hakim terssebut berupaya menngkaji ketentuan itu dalam hukum tidak ditulis ataupun berupaya mencari cara untuk menemukan aturannya dalam Kompilasi Hukum Islam
Mathematical Critical Thinking Abilities of Middle School Students in Tidore Based on Gender and Background
Authors: Said Arwan Mhd , Lukmana Dana Arif 
Published: July 2022

This study was conducted to answer the question, "What is the description of the mathematical critical thinking ability of middle school students in Tidore city based on gender and background?". This question is essential to answer because it is motivated by the mathematical performance of students in Tidore is low nationally and is reinforced by the results of the 2015 and 2018 PISA and OECD surveys. Gender is used as a distinguishing factor because this factor is still culturally rooted in this area and affects the role of society in life socially. Tidore comprises three significant communities, namely coastal, urban, and mountainous communities, each of which has a unique pattern of social life. Therefore, researchers also use "background" as a distinguishing factor. Data collection was carried out in three schools representing the three communities using a questionnaire, math problems (arithmetic, geometry, algebra), and semi-structured interviews on two subjects (male and female) in each location. The results of the analysis show, based on gender and background the ability of students to think critically mathematically are categorized as sufficient (close to less) with a mathematical critical thinking (MCT) achievement ratio of 0.27. Male subjects had an achievement ratio of 0.3 (sufficient) higher than female subjects of 0.24 (insufficient). Based on the background subjects from urban areas had the highest MCT achievement ratio of 0.49 (sufficient) while the subject achievement ratio of the coast and mountains were 0.17 (insufficient) and 0.15 (insufficient), respectively.
SEMIOTIKA DALAM IKLAN SABUN LUX VERSI SOFT TOUCH
Authors: Wulandari Catur , Agustina Emi 
Published: August 2022

Penelitian ini bertujuan untuk mengkaji semiotika dalam iklan sabun Lux versi Soft Touch. Metode penelitian yang digunakan adalah deskriptif kualitatif yang akan menggambarkan peristiwa atau fenomena yang terjadi secara objektif. Berdasarkan hasil penelitian dapat disimpulkan bahwa tahap-tahap semiotika Roland Bather ,yaitu tahap denotasi, konotasi, dan mitos membuat makna tersirat dari iklan sabun Lux versi soft touch diketahui. Pada tahap denotasi, tanda yang terdapat dalam wacana iklan sabun Lux versi soft touch adalah perempuan yang mandi dengan sabun Lux di bath tub membuat tubuhnya harum dan lembut serta dapat menggoda pasangannya. Selanjutnya, pada tahap konotasi, sabun Lux ini memakai keharuman bunga. Bunga merupakan simbol karena keharuman dan bentuknya yang indah. Bunga juga merupakan lambang ungkapan perasaan cinta. Pembuatan sabun ini bertujuan untuk membangkitkan getaran cinta pada setiap pasangan. Terakhir, pada tahap mitos, ada enam mitos yang ditemukan dalam wacana iklan sabun Lux versi soft touch ini, yaitu (1) Keharuman bunga yang khas dapat membangkitkan suasana yang romantis. Hal ini dikaitkan dengan bunga sebagai lambang cinta; (2) para perempuan sebaiknya berinisiatif menggoda pasangannya sehingga getaran cinta antara mereka bangkit kembali; (3) perempuan menyukai perawatan kecantikan yang murah dan praktis; (4) laki-laki suka perempuan yang memakai pakaian agak terbuka dan berwarna cerah; (5) jika cinta sudah melekat di mana pun pasangan itu berada, dunia serasa hanya milik mereka berdua; dan (6) Semakin tinggi kelas sosialnya, maka semakin modern dan cenderung meniru gaya hidup orang eropa.
Pengaruh Profitabilitas (ROA), Likuiditas (AKO), Ukuran Perusahaan (SIZE), dan Leverage (LTDER) terhadap Nilai Perusahaan
Authors: Natalie Vannessa , Lisiantara G. Anggana 
Published: July 2022

Firm value is the investor's perception of a company related to stock prices. High company value will make the market not only believe in the company's current performance, but also on its future prospects. In the preparation of this study, the aim was to examine and analyze the effect of profitability, liquidity, company size, and leverage on firm value in property and real estate companies listed on the Indonesia Stock Exchange (IDX) for the 2017-2021 period. This study uses a population of all property and real estate companies that have been listed on the Indonesia Stock Exchange (IDX) in the last five periods, namely 2017-2021. The sample selection method used in this study was a purposive sampling technique with several selected criteria, so as to obtain a sample of 105 companies. This study uses secondary data in the form of numbers that are processed into a statistical measurement scale, so it is called secondary data. The data analysis technique used is multiple linear regression analysis. The results of this study indicate that profitability (ROA) and firm size (SIZE) have no effect on firm value, liquidity (AKO) has a positive and significant effect on firm value, while leverage (LTDER) has a negative and significant effect on firm value.
Approach to the Treatment of Pediatric Dystonia
Authors: Gorodetsky Carolina , Fasano Alfonso 
Published: August 2022

Dystonia is the most common movement disorder in the pediatric population. It can affect normal motor development and cause significant motor disability. The treatment of pediatric dystonia can be very challenging as many children tend to be refractory to standard pharmacological interventions. Pharmacological treatment remains the first-line approach in pediatric dystonia. However, despite the widespread use of different ani-dystonia medications, the literature is limited to small clinical studies, case reports, and experts’ opinions. Botulinum neurotoxin (BoNT) is a well-established treatment in adults with focal and segmental dystonia. Despite the widespread use of BoNT in adult dystonia the data to support its use in children is limited with the majority extrapolated from the spasticity literature. For the last 2 decades, deep brain stimulation (DBS) has been used for a wide variety of dystonic conditions in adults and children. DBS gained increased popularity in the pediatric population because of the dramatic positive outcomes reported in some forms of genetic dystonia and the subsequent consensus that DBS is generally safe and effective. This review summarizes the available evidence supporting the efficacy and safety of pharmacological treatment, BoNT, and DBS in pediatric dystonia and provides practical frameworks for the adoption of these modalities.
A nomogram for clinical estimation of acute biliary pancreatitis risk among patients with symptomatic gallstones: A retrospective case-control study
Authors: Guo Xiaoyu , Li Yilong , Lin Hui , Cheng Long , Huang Zijian , Lin Zhitao , Mao Ning , Sun Bei , Wang Gang , Tang Qiushi 
Published: August 2022

Background/PurposeCurrently, there are no effective tools to accurately assess acute biliary pancreatitis (ABP) risk in patients with gallstones. This study aimed to develop an ABP risk nomogram in patients with symptomatic gallstones.MethodsWe conducted a retrospective nested case-control study and data on 816 conservatively treated patients with symptomatic gallstones admitted to The First Affiliated Hospital of Harbin Medical University between January 6, 2007 and January 22, 2016 were retrospectively collected. We conducted a propensity-score matched (PSM) analysis based on follow-up time in a ratio of 1:4 between ABP group (n=65) and non-ABP group (n=260). These matched patients were randomly divided into study cohort (n=229) and validation cohort (n=96) according to a ratio of 7:3. In the study cohort, independent risk factors for ABP occurrence identified using Cox regression were included in nomogram. Nomogram performance and discrimination were assessed using the concordance index (C-index), area under the curve (AUC), calibration curve, decision curve analysis (DCA) and clinical impact curve (CIC). The model was also validated in the validation cohort.ResultsNomogram was based on 7 independent risk factors: age, diabetes history, gallbladder wall thickness, gallstone diameter, coexisting common bile duct (CBD) stones, direct bilirubin (DBIL), and white blood cell count (WBC). The C-index of nomogram was 0.888, and the 10-year AUCs of nomogram was 0.955. In the validation cohort, nomogram still had good discrimination (C-index, 0.857; 10-year AUC, 0.814). The calibration curve showed good homogeneity between the prediction by nomogram and the actual observation. DCA and CIC demonstrated that nomogram was clinically useful.ConclusionsThe ABP risk nomogram incorporating 7 features is useful to predict ABP risk in symptomatic gallstone patients.
D-Dimer Is Associated With Coronary Microvascular Dysfunction in Patients With Non-obstructive Coronary Artery Disease and Preserved Ejection Fraction
Authors: Lin Yan , Hu Xiangming , Wang Weimian , Yu Bingyan , Zhou Langping , Zhou Yingling , Li Guang , Dong Haojian 
Published: August 2022

BackgroundCoronary microvascular dysfunction (CMVD), an important etiology of ischemic heart disease, has been widely studied. D-dimer is a simple indicator of microthrombosis and inflammation. However, whether an increase in D-dimer is related to CMVD is still unclear.Materials and MethodsThis retrospective study consecutively enrolled patients with myocardial ischemia and excluded those with obstructive coronary artery. D-dimer was measured at admission and the TIMI myocardial perfusion grade (TMPG) was used to distinguish CMVD. Patients were divided into the two groups according to whether the D-dimer was elevated (&gt;500 ng/ml). Logistic models and restricted cubic splines were used to explore the relationship between elevated D-dimer and CMVD.ResultsA total of 377 patients were eventually enrolled in this study. Of these, 94 (24.9%) patients with CMVD had older age and higher D-dimer levels than those without CMVD. After full adjustment for other potential clinical risk factors, patients with high D-dimer levels (&gt;500 ng/ml) had a 1.89-times (95% CI: 1.09–3.27) higher risk of CMVD than patients with low D-dimer levels. A non-linear relationship was found between concentrations of D-dimer and CMVD. With increased D-dimer level, the incidence of CMVD increased and then remained at a high level. Stratified analysis was performed and showed similar results.ConclusionElevated D-dimer level is associated with the incidence of CMVD and potentially serves as a simple biomarker to facilitate the diagnosis of CMVD for patients with angina.
Hydroxychloroquine overcomes cabergoline resistance in a patient with Lactotroph Pituitary neuroendocrine tumor: a case report
Authors: Lin Shaojian , Han Changxi , Lou Xiaohui , Wu Zhe Bao 
Published: August 2022

ObjectiveA 22-year-old man complaining erectile dysfunction underwent transsphenoidal surgery for a 2.7 cm sellar mass with total resection and was confirmed at pathology to have a lactotroph pituitary neuroendocrine tumor (PiNET). Postoperatively, the patient’s PRL remained at high level and therefore accepted high-dose dopamine receptor agonist (DA) therapy. After over 3 months of bromocriptine (BRC) (15mg/day) and over 3 years of cabergoline (CAB) (3mg/week) therapy, the patient’s prolactin (PRL) never achieved long-term normalization. He was diagnosed with DA-resistant lactotroph PitNET.MethodIn this study, the patient was given hydroxychloroquine (HCQ) (200 mg/d) and CAB (3 mg/w) in combination for four months. His PRL level was tested by blood test every month.ResultsTaking the combination therapy of HCQ and CAB, the patient’s uncontrolled PRL level was normalized within one month and was maintained at the normal level thereafter. Pituitary magnetic resonance imaging (MRI) images with enhancement showed no recurrence. The patient also regained normal sexual function.DiscussionThis is the first report on the combination of HCQ with CAB for the effective treatment of DA-resistant lactotroph pituitary neuroendocrine tumor in a patient, which might provide a novel treatment strategy for clinical management.
Gut microbiota in systemic lupus erythematosus patients and lupus mouse model: a cross species comparative analysis for biomarker discovery
Authors: Toumi Eya , Goutorbe Benoit , Plauzolles Anne , Bonnet Marion , Mezouar Soraya , Militello Muriel , Mege Jean-Louis , Chiche Laurent , Halfon Philippe 
Published: August 2022

An increasing number of studies have provided strong evidence that gut microbiota interact with the immune system and stimulate various mechanisms involved in the pathogenesis of auto-immune diseases such as Systemic Lupus Erythematosus (SLE). Indeed, gut microbiota could be a source of diagnostic and prognostic biomarkers but also hold the promise to discover novel therapeutic strategies. Thus far, specific SLE microbial signatures have not yet been clearly identified with alteration patterns that may vary between human and animal studies. In this study, a comparative analysis of a clinically well-characterized cohort of adult patients with SLE showed reduced biodiversity, a lower Firmicutes/Bacteroidetes (F/B) ratio, and six differentially abundant taxa compared with healthy controls. An unsupervised clustering of patients with SLE patients identified a subgroup of patients with a stronger alteration of their gut microbiota. Interestingly, this clustering was strongly correlated with the disease activity assessed with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score (p = 0.03, odd ratio = 15) and the identification of specific alterations involving the F/B ratio and some different taxa. Then, the gut microbiota of pristane-induced lupus and control mice were analyzed for comparison with our human data. Among the six differentially abundant taxa of the human disease signature, five were common with our murine model. Finally, an exhaustive cross-species comparison between our data and previous human and murine SLE studies revealed a core-set of gut microbiome species that might constitute biomarker panels relevant for future validation studies.
Lionfish on the loose: Pterois invade shallow habitats in the tropical southwestern Atlantic
Authors: Soares Marcelo O. , Feitosa Caroline V. , Garcia Tatiane M. , Cottens Kelly Ferreira , Vinicius Bruno , Paiva Sandra Vieira , Duarte Oscar de Sousa , Gurjão Lívio Moreira , Silva Grasielle Dayse de Vasconcelos , Maia Rafaela Camargo , Previatto Diego M. , Carneiro Pedro B. M. , Cunha Edna , Amâncio Antonio Carlos , Sampaio Claudio L. S. , Ferreira Carlos E.L. , Pereira Pedro H.C. , Rocha Luiz A. , Tavares Tallita C. L. , Giarrizzo Tommaso 
Published: August 2022

Lionfish (Pterois spp.) evolved in the Indo-Pacific with predators and prey and invaded regions (e.g., the Caribbean Sea and Mediterranean) where no such balance yet exists. In 2020, four lionfish were recorded on mesophotic reefs of the Amazon offshore Coast and Fernando de Noronha Archipelago. However, until now, there were no records of invasive lionfish in Brazilian nearshore waters or even such a high number of individuals. In this article, we report the continuing invasion process along the Brazilian Province by multiple sightings (72) of lionfish from March to May 2022 in estuaries, seagrass beds, and artificial and natural reefs across 240 km of the Brazilian coast. These are the first records of lionfish in coastal northeast Brazil and the shallowest records (1–16 m) from South Atlantic tropical waters. The largest simultaneous records of lionfish in breakwaters, fishing weirs, and marambaias (artificial reefs used as fishing grounds) on the Brazilian Northeastern coast indicate that these man-made structures are suitable habitats for this species. Most of the lionfish (58%) were recorded in artificial reefs and fishing weirs. Moreover, the detection of invasions in marginal reefs, estuaries, and two marine protected areas characterized by moderately turbid water and high sedimentation rates highlights the adaptability of the lionfish, making it extremely difficult for divers and fishers to capture them. We call for an urgent management plan considering that the invaded tropical region hosts a high level of endemism, and rare and/or cryptic taxa, which increases the risk of impacts since these are primary lionfish prey.
Survival and adverse events of elderly patients treated with sorafenib for hepatocellular carcinoma
Authors: Soria Anna , Calvo Mariona , Casas Meritxell , Vidales Zara , Muñoz-Martínez Sergio , Sapena Victor , Puigvehi Marc , Canillas Lidia , Guardeño Raquel , Gallego Adolfo , Mínguez Beatriz , Horta Diana , Clos Ariadna , Montoliu Silvia , Roget Mercè , Reig Maria , Vergara Mercedes 
Published: August 2022

IntroductionThe first-line treatment for advanced hepatocellular carcinoma (HCC) is atezolizumab plus bevacizumab, but its availability is not universal and elderly patients are underrepresented in clinical trials. There is little evidence of efficacy and tolerability in elderly patients under systemic treatment. The aims of this study were to characterize the profile of elderly patients treated with sorafenib, assess their survival and safety profile in order to extrapolate their eligibility for systemic treatment.MethodsRetrospective multicentre study of HCC patients aged ≥75 years old treated with sorafenib from January 2008 to December 2019. Demographic data, baseline characteristics, and variables related to HCC and sorafenib were recorded. Overall survival (OS) and safety were analyzed.ResultsThe study included 206 patients from 11 hospitals, median age 77.9 years; 71.4% men and 62.6% stage Barcelona Clinic Liver Cancer- C (BCLC-C). The main causes of cirrhosis were hepatitis C (60.7%) and alcohol (14.7%). Most patients (84.5%) started with sorafenib 800mg and 15.5% at lower dosage. Arterial hypertension (AHT) (74.2 vs 62.2%; standardized mean differences (STD): 26) and baseline ECOG-PS&gt;0 (45.3 vs 34.7%; STD: 38.2) differed significantly between patients receiving low and full doses. Median OS was 15.4 months (18.2 in BCLC-B vs 13.6 in BCLC-C). OS was not modified by comorbidities, age or period with more expertise.ConclusionsSorafenib appears to be safe in elderly patients with HCC. This is the first study to characterize the profile of elderly patients to be considered for systemic treatment. These findings could be used as the reference profile for elderly candidates for atezolizumab-bevacizumab.
Retinoblastoma in Adults: Clinical Features, Gene Mutations and Treatment Outcomes: A Study of Six Cases
Authors: Zhou Nan , Yang Lihong , Xu Xiaolin , Liu Yueming , Wei Wenbin 
Published: August 2022

PurposeTo report six Asian adult patients with retinoblastoma (RB).DesignRetrospective and observational small case series.ParticipantsSix patients with a white dome-shaped tumor of the retina were evaluated from May 10, 1995, to September 10, 2021.Main Outcome MeasuresInitial tumor and associated fundus features, pathology, gene mutation, treatment, tumor course on follow-up, and salvage globe outcome.ResultsThe six affected Asian patients consisted of three men and three women. The mean age at the time of diagnosis was 36.5 years (median: 31 years, range: 20-55 years). All patients were unilateral. In all cases, the tumors were white, dome-shaped, with full-thickness retinal involvement, and mushroom-like protrusions into the vitreous cavity. The mean tumor thickness measured by ultrasonography was 4.5 mm (median: 3.2 mm, range: 3.2-6.8 mm). Associated characteristic symptoms included dilated retinal feeding artery and draining vein (100%), surrounding subretinal infiltration (83%), exudative retinal detachment (83%), and vitreous seeds (67%). Local tumor resection was performed in three patients, I-125 plaque brachytherapy combined with transpupillary thermotherapy (TTT) and intravitreous injection of melphalan (combination treatment) in one patient, I-125 plaque brachytherapy in two patients, and enucleation in one (20%) patient. RB1 gene testing was carried out on four patients and pathological diagnosis on five patients. Genetic analysis revealed that the RB1 mutation was a mosaic c.709dupG (p.Glu237GlyfsTer4) duplication in one patient, a mosaic c.763C&gt;T(p.Arg255Ter) mutation in another patient, while the remaining two patients were RB1 negative. At the end of the follow-up, none of the patients had developed tumor-related metastasis or died. The findings were consistent in all patients who had an adequate follow-up. This study focused on this rare lesion to distinguish it from other intraocular white lesions in adults, including choroidal osteoma, vitreoretinal lymphoma, and retinal capillary hemangioma, all of which are different clinical entities.ConclusionIn adults, RB is typically a white, full-thickness retinal mass that is unilateral, often combining with retinal feeding vessels, subretinal infiltration, and vitreous seeds. Genetic studies on adult-onset RB are essential and still require elucidation. Despite RB being a malignant tumor, patient survival was minimally affected.