bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) index: an analysis of reorientation technique of the OASIS-3 dataset
Authors: Tatekawa Hiroyuki , Matsushita Shu , Ueda Daiju , Takita Hirotaka , Horiuchi Daisuke , Atsukawa Natsuko , Morishita Yuka , Tsukamoto Taro , Shimono Taro , Miki Yukio 
Published: December 2022

Abstract
Purpose
Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is intended to reflect the glymphatic function of the brain; however, head rotation may reduce reproducibility and reliability. This study aimed to evaluate whether reorientation of DTI data improves the reproducibility of the ALPS index using the OASIS-3 dataset.

Materials and methods
234 cognitively normal subjects from the OASIS-3 dataset were included. Original and reoriented ALPS indices were calculated using a technique that registered vector information of DTI to another space and created reoriented diffusivity maps. The F test was used to compare variances of the original and reoriented ALPS indices. Subsequently, subjects with head rotation around the z- (inferior-superior; n = 43) or x axis (right-left; n = 25) and matched subjects with neutral head position were selected for evaluation of intra- and inter-rater reliability. Intraclass correlation coefficients (ICCs) of the original and reoriented ALPS indices for participants with head rotation and neutral head position were calculated separately. The Bland–Altman plot comparing the original and reoriented ALPS indices was also evaluated.

Results
The reoriented ALPS index exhibited a significantly smaller variance than the original ALPS index (p < 0.001). For intra- and inter-reliability, the reorientation technique showed good-to-excellent reproducibility in calculating the ALPS index even in subjects with head rotation (ICCs of original ALPS index: 0.52–0.81; ICCs of reoriented ALPS index: > 0.85). A wider range of the 95% limit of agreement of the Bland–Altman plot for subjects with x axis rotation was identified, indicating that x axis rotation may remarkably affect calculation of the ALPS index.

Conclusion
The technique used in this study enabled the creation of reoriented diffusivity maps and improved reproducibility in calculating the ALPS index.
Adalimumab (Humira®) Induced Recurrent Peritonsillar Abscess in A Patient Received Three Different Anti-TNF Therapies: A Case Report
Authors: Vural Sevilay , Kuşdoğan Mikail , Kaya Hasan Burak , İkiz Venhar , Albayrak Levent 
Published: December 2022

AbstractAnti-tumor necrosis factor agents are widely used in treating ankylosing spondylitis, but they increase the risk of infection by suppressing the immune response. Therefore, physicians should be careful about recurrent infections in patients under anti-tumor necrosis factor agents.
Evaluating species richness using proteomic fingerprinting and DNA barcoding—a case study on meiobenthic copepods from the Clarion Clipperton Fracture Zone
Authors: Rossel Sven , Uhlenkott Katja , Peters Janna , Vink Annemiek , Arbizu Pedro Martínez 
Published: December 2022

AbstractThe Clarion Clipperton Fracture Zone (CCZ) is a vast deep-sea region harboring a highly diverse benthic fauna, which will be affected by potential future deep-sea mining of metal-rich polymetallic nodules. Despite the need for conservation plans and monitoring strategies in this context, the majority of taxonomic groups remain scientifically undescribed. However, molecular rapid assessment methods such as DNA barcoding and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) provide the potential to accelerate specimen identification and biodiversity assessment significantly in the deep-sea areas. In this study, we successfully applied both methods to investigate the diversity of meiobenthic copepods in the eastern CCZ, including the first application of MALDI-TOF MS for the identification of these deep-sea organisms. Comparing several different species delimitation tools for both datasets, we found that biodiversity values were very similar, with Pielou’s evenness varying between 0.97 and 0.99 in all datasets. Still, direct comparisons of species clusters revealed differences between all techniques and methods, which are likely caused by the high number of rare species being represented by only one specimen, despite our extensive dataset of more than 2000 specimens. Hence, we regard our study as a first approach toward setting up a reference library for mass spectrometry data of the CCZ in combination with DNA barcodes. We conclude that proteome fingerprinting, as well as the more established DNA barcoding, can be seen as a valuable tool for rapid biodiversity assessments in the future, even when no reference information is available.
Estimated daily intake of epichlorohydrin and certain heavy metals of bagged and loose black teas
Authors: Nour Suheir M. F. , El-Desoky Amany M. M. , Hassan Nagla A. , Osman Khaled A. 
Published: December 2022

AbstractThis study aimed to determine the levels of epichlorohydrin (ECH) and some metals in 3 brands of bagged and loose black teas which are widely marketed in Alexandria markets, Egypt, and estimate the acceptable daily intake as a safety indicator. Gas chromatography–mass spectrometry results revealed that ECH levels significantly differed between the tested brands steeped for 2 min and tea bags contained higher levels than in loose teas and the levels increased by increasing the steep time. These levels of ECH in all the tested brands either in tea bags or loose teas were higher than the guideline value of 0.10 μg/L. Also, the results illustrated that the adding of sucrose or washing of bags with deionized water for 1 min significantly decreased the levels of ECH. In addition, inductively coupled plasma optic emission spectrometry (ICP–OES) results illustrated that the levels of Al, Pb, and Cd were too low in infusions compared to the established guidelines. Because of the high consumption of tea in Alexanria city, Egypt, it is necessary to determine the contribution of tea to the daily dietary intake of ECH, Al, Pb and Cd. In case of the bagged teas, the calculated daily intake of ECH was on average about 55.37 times greater than that in loose teas. The consumption of both bagged and loose teas infusion could not pose a risk for population as the health hazard index was < 1. It can be concluded that consumers who prefer to use tea bags should rinse these bags before preparing the tea brewer, and do not increase the steeping time to more than 2 min.
The effectiveness of video animations in the education of healthcare practitioners
and student practitioners: a systematic review of trials
Authors: Knapp Peter , Benhebil Nadia , Evans Ella , Moe-Byrne Thirimon 
Published: December 2022

Introduction Video animations are increasingly available in education but without
systematic evaluation. This review aimed to collate trials of animations versus other
delivery, in student or qualified healthcare practitioners. Methods Included
studies had the following features: controlled design with random or quasi-random
allocation; student or qualified healthcare practitioners; comparing video animation
with another format (e.g. textbook, lecture, static images); animation delivered instead
of, or in addition to, another format. The primary outcome was knowledge; secondary
outcomes were attitudes and cognitions, and behaviours. Multiple databases were searched
from 1996-October 2022 using a defined strategy. We also undertook citation searching.
Dual, independent decision-making was used for inclusion assessment, data extraction,
and quality appraisal. Included studies were appraised using the Cochrane ROB2 tool.
Findings were reported using narrative synthesis. Results We included 13 studies:
11 recruited student practitioners, two recruited qualified practitioners, total
n = 1068. Studies evaluated cartoon animations or 2D/3D animations. Knowledge was
assessed in ten studies, showing greater knowledge from animations in eight studies.
Attitudes and cognitions were assessed in five studies; animations resulted in positive
outcomes in three studies, no difference in one study, and worse outcomes in one study.
Behaviours were assessed in three studies, animations producing positive outcomes in two
studies and there was no difference in one study. Overall risk of bias was ‘high’ in ten
studies and ‘some concerns’ in three.
A Rising 2D Star: Novel MBenes with Excellent Performance in Energy Conversion and Storage
Authors: Xu Tianjie , Wang Yuhua , Xiong Zuzhao , Wang Yitong , Zhou Yujin , Li Xifei 
Published: December 2022

AbstractAs a flourishing member of the two-dimensional (2D) nanomaterial family, MXenes have shown great potential in various research areas. In recent years, the continued growth of interest in MXene derivatives, 2D transition metal borides (MBenes), has contributed to the emergence of this 2D material as a latecomer. Due to the excellent electrical conductivity, mechanical properties and electrical properties, thus MBenes attract more researchers' interest. Extensive experimental and theoretical studies have shown that they have exciting energy conversion and electrochemical storage potential. However, a comprehensive and systematic review of MBenes applications has not been available so far. For this reason, we present a comprehensive summary of recent advances in MBenes research. We started by summarizing the latest fabrication routes and excellent properties of MBenes. The focus will then turn to their exciting potential for energy storage and conversion. Finally, a brief summary of the challenges and opportunities for MBenes in future practical applications is presented.
Age, ageing, and the philosophy of ‘elder law’: An interview with Israel (Issi) Doron
Authors: Gandhi Ankita 
Published: December 2022

AbstractGerontology—the multidisciplinary study of the process of ageing and its medical and social consequences for older adults—has often not been given its due by either legal practitioners or legal academics. While we have witnessed several social movements advocating for the rights and interests of other marginalised groups, discrimination against older adults has also not been the subject of any mass action comparable to those movements. Consequently, the position of older adults within legal systems has frequently been bypassed, especially outside the United States of America. However, the COVID-19 pandemic suddenly brought the precarious position of older adults into the spotlight, be it in care homes during lockdowns or in hospitals through several waves or with regard to priority access to vaccines. At each juncture, governments took recourse to legal regulation to mitigate the impact of the disease on what they understood to be the most vulnerable sections of the population. But some of these rules were subjected to criticism, especially from older adults themselves, because of their overbreadth, and on account of the protectionism and infantilisation of older adults that they entailed. In this interview, Professor Israel (Issi) Doron, Dean of the Faculty of Social Welfare and Health Sciences of the University of Haifa, Israel, discusses how academia, strategic litigation, and advocacy and activism have finally begun taking the field of ‘jurisprudential gerontology’ into serious consideration.
Refining the Implementation of a Hub-and-Spoke Model for TelePain Through Qualitative Inquiry
Authors: Subramaniam Soumya , Chen Jessica , Wilkerson Tai-Lyn , Stevenson Lauren , Kincaid Carrie , Firestone Christine , Ball Sherry L. 
Published: December 2022

AbstractThe hub-and-spoke telehealth model leverages centrally located providers who utilize telehealth technology to bring specialized care to medically underserved areas. This model has the potential to promote equitable access to healthcare. However, few studies address how to facilitate the adoption and implementation of hub-and-spoke telehealth. We examined spoke site providers’ experiences with TelePain, a national hub-and-spoke model of interdisciplinary chronic pain care, with a focus on improving future implementation. We conducted semi-structured individual interviews (20–45 min) with 27 VA spoke site providers via teleconferencing between August 2020 and February 2021. Interview transcripts were coded in Atlas.ti 8.0 using deductive (identified a priori and used to build the interview guide) and inductive (emerging) codes. Our analysis identified the following themes stressed by the spoke sites: (1) spoke sites needed to envision how TelePain services would work at their site before deciding to adopt; (2) TelePain implementation needed to fit into local existing care processes; (3) hub sites needed to understand spoke sites’ context (e.g., via needs assessment) to tailor the services accordingly, and (4) hub-and-spoke sites needed to establish bidirectional communication. Our findings provide a practical guide to improve future rollout of hub-and-spoke telehealth models. Recommendations focus on the role of the hub site in promoting program adoption by (1) developing a clear and detailed marketing plan and (2) considering how the program can be adapted to fit the local spoke site context. To improve implementation, hub-and-spoke sites must establish ongoing and consistent bidirectional communication; this is particularly critical in the everchanging post-peak pandemic healthcare system. An important next step is the development of recommendations and guidelines for implementing hub-and-spoke telehealth, as well as examining pain outcomes for patients touched by this program.
Reliability of an Interpretation Bias Task of Ambiguous Faces and Its Relationship with Social Anxiety, Depression, and Looming Maladaptive Style
Authors: Prieto-Fidalgo Ángel , Mueller Sven C. , Calvete Esther 
Published: December 2022

AbstractSocial anxiety (SA) and depression have been associated with negative interpretation biases of social stimuli. Studies often assess these biases with ambiguous faces, as people with SA and depression tend to interpret such faces negatively. However, the test–retest reliability of this type of task is unknown. Our objectives were to develop a new interpretation bias task with ambiguous faces and analyse its properties in terms of test–retest reliability and in relation to SA, depression, and looming maladaptive style (LMS). Eight hundred sixty-four participants completed a task in which they had to interpret morphed faces as negative or positive on a continuum between happy and angry facial expressions. In addition, they filled out scales on SA, depressive symptoms, and LMS. Eighty-four participants completed the task again after 1–2 months. The test–retest reliability was moderate (r = .57–.69). The data revealed a significant tendency to interpret faces as negative for people with higher SA and depressive symptoms and with higher LMS. Longer response times to interpret the happy faces were positively associated with a higher level of depressive symptoms. The reliability of the present task was moderate. The results highlight associations between the bias interpretation task and SA, depression, and LMS.
A two-parameter family of non-parametric, deformed exponential manifolds
Authors: Newton Nigel J. 
Published: December 2022

AbstractWe construct a new family of non-parametric statistical manifolds by means of a two-parameter class of deformed exponential functions, that includes functions with power-law, linear and sublinear rates of growth. The manifolds are modelled on weighted, mixed-norm Sobolev spaces that are especially suited to this purpose, in the sense that an important class of nonlinear superposition operators (those used in the construction of divergences and tensors) act continuously on them. We analyse variants of these operators, that map into “subordinate” Sobolev spaces, and evaluate the associated gain in regularity. With appropriate choice of parameter values, the manifolds support a large variety of the statistical divergences and entropies appearing in the literature, as well as their associated tensors, eg. the Fisher-Rao metric. Manifolds of finite measures and probability measures are constructed; the latter are shown to be smoothly embedded submanifolds of the former.
Strong Stability Preserving Runge–Kutta and Linear Multistep Methods
Authors: Izzo Giuseppe , Jackiewicz Zdzislaw 
Published: December 2022

AbstractThis paper reviews strong stability preserving discrete variable methods for differential systems. The strong stability preserving Runge–Kutta methods have been usually investigated in the literature on the subject, using the so-called Shu–Osher representation of these methods, as a convex combination of first-order steps by forward Euler method. In this paper, we revisit the analysis of strong stability preserving Runge–Kutta methods by reformulating these methods as a subclass of general linear methods for ordinary differential equations, and then using a characterization of monotone general linear methods, which was derived by Spijker in his seminal paper (SIAM J Numer Anal 45:1226–1245, 2007). Using this new approach, explicit and implicit strong stability preserving Runge–Kutta methods up to the order four are derived. These methods are equivalent to explicit and implicit RK methods obtained using Shu–Osher or generalized Shu–Osher representation. We also investigate strong stability preserving linear multistep methods using again monotonicity theory of Spijker.
A Novel Image Encryption Technique Using Multi-Coupled Map Lattice System with Generalized Symmetric Map and Adaptive Control Parameter
Authors: Zia Syed Muhammad Unsub , McCartney Mark , Scotney Bryan , Martinez Jorge , Sajjad Ali 
Published: December 2022

AbstractImage and video data make up a significant portion of the content shared over the Internet and social media. The use of image and video communication allows more information to be shared while simultaneously presenting higher risks in terms of data security. The traditional encryption schemes are general purpose; however, to encrypt image and video data, application-specific encryption solutions are needed. An image or a video frame comprises a two-dimensional matrix where pixel intensity values are integers in range [0,255], leading to data redundancy problems. Moreover, the bulk amount of image and video data adds another challenge when deploying security primitives. In this paper, a novel coupled map lattice system-based image cryptosystem has been proposed that uses generalised symmetric maps for generation of pseudo-random sequences. The generalization of symmetric maps allows the user to choose the source of pseudo-random sequence generation by varying a single control parameter. Other adaptive control parameters ensure an adequate degree of randomness in the generated sequences. The proposed encryption system relies on three independent sources of pseudo-random sequence generators, which are further re-randomized before the final encryption process. Comprehensive experimentation has been performed to test the proposed system against various attack models on publicly available datasets. A detailed comparative analysis has also been conducted with existing state-of-the-art image encryption techniques. Results show that the proposed algorithm provides high information entropy, negative correlation, large key space, and high sensitivity to key variations, and is resistant to various types of attacks, including chosen-text, statistical, and differential attacks.
Identification of a Novel Cuproptosis-Related Gene Signature in Eutopic Endometrium of Women with Endometriosis
Authors: Wei Jiahui , Huang Baoyi , Nong Yingqi , Zhang Qianyu , Liu Wenjuan , Xie Yanni , Peng Tong , Wang Wei , Liang Xiangping , Li Qiuyun , Liu Fenghua 
Published: December 2022

AbstractEndometriosis (EMs) is a life-long endocrine disorder and a common cause for female infertility and pelvic pain. The key characteristics of eutopic endometrium of EMs patients are high proliferative and migratory potentials. Cuproptosis is a recently identified copper- and-mitochondrial-dependent regulated cell death. Regretfully, its role in EMs remains unclear. In this study, Kyoto Encyclopedia of Genes and Genomes analyses of differentially expressed genes (DEGs) indicated strong activation of the PI3K-Akt-mTOR pathway and biological process analysis reported positive regulation of kinase activity. Next, we screened 11 cuproptosis-related DEGs and found all of them were downregulated in the EMs group, which indicated the suppression of cuproptosis in EMs. One key cuproptosis-related gene, PDHA1, was selected via support vector machine, random forest algorithm and lasso regularization to build a risk-scoring model, which was tested in both internal and external validations. In conclusion, the downregulation and kinase activity of PDHA1 may function with the PI3K-Akt-mTOR pathway in some way, which could suppress the cuproptosis level and account for the cancer-like pathology in EMs.
A kinetic study of the photolysis of sulfamethoxazole with special emphasis on the photoisomer
Authors: Palm Wolf-Ulrich , Schmidt Nicola , Stahn Marcel , Grimme Stefan 
Published: December 2022

Abstract
The previously not studied photochemical degradation of sulfamethoxazole (SMX) to the isomer of SMX (ISO) was measured via a polychromatic (Xe) and a monochromatic (Hg) light source and accompanied by quantum chemical DFT calculations. In addition to the $$\mathrm{p}K_\mathrm{a} = \;7.0 \pm 0.1$$

p

K
a

=

7.0
±
0.1

of ISO, tautomer-dependent properties such as the $$K_\mathrm{OW}$$

K
OW

were measured and theoretically confirmed by DFT. The kinetics in solutions below and above the $$\mathrm{p}K_\mathrm{a} = 5.6$$

p

K
a

=
5.6

of SMX were studied for the available and quantifiable products SMX, ISO, 3-amino-5-methylisoxazole (AMI), 2-amino-5-methyloxazole (AMO), and sulfanilic acid (SUA). The quantum yields of the neutral ($$\Phi _\mathrm{N}$$

Φ
N

) and anionic $$\Phi _\mathrm{A}$$

Φ
A

) forms of SMX ($$\Phi _\mathrm{A} = 0.03 \pm 0.001$$

Φ
A

=
0.03
±
0.001

, $$\Phi _\mathrm{N} = 0.15 \pm 0.01$$

Φ
N

=
0.15
±
0.01

) and ISO ($$\Phi _\mathrm{A} = 0.05 \pm 0.01$$

Φ
A

=
0.05
±
0.01

and $$\Phi _\mathrm{N} = 0.06 \pm 0.02$$

Φ
N

=
0.06
±
0.02

) were found to be wavelength-independent. In a competitive reaction to the formation of ISO from SMX, the degradation product TP271 is formed. Various proposed structures for TP271 described in the literature have been studied quantum mechanically and can be excluded for thermodynamic reasons. In real samples in a northern German surface water in summer 2021 mean concentrations of SMX were found in the range of 120 ng/L. In agreement with the pH-dependent yields, concentrations of ISO were low in the range of 8 ng/L.

Graphical abstract