bluuebunny/crossref_metadata_2025_split huggingface dataset:
GNSS observable-specific phase biases for all-frequency PPP ambiguity resolution
Authors: Geng Jianghui , Wen Qiang , Zhang Qiyuan , Li Guangcai , Zhang Kunlun 
Published: February 2022

AbstractAn unwritten rule to resolve GNSS ambiguities in precise point positioning (PPP-AR) is that users should follow faithfully the frequency choices and observable combinations mandated by satellite clock and phase bias providers. Switching to other frequencies of measurements requires that the satellite clocks be converted, albeit in a roundabout way, to agree with the new frequencies of code biases. Satellite phase biases, on the other hand, are prescribed conventionally as wide-lane and narrow-lane combinations, which prevents users from resolving other phase combinations in the case of multi-frequency observables. We therefore develop an approach to compute observable-specific phase biases (phase OSBs) in concert with the legacy, but ambiguity-fixed, satellite clocks to enable PPP-AR over any frequency choices and observable combinations at the user end, i.e., all-frequency PPP-AR. In particular, the phase OSBs on the baseline frequencies (e.g., L1/L2 for GPS and E1/E5a for Galileo) are estimated by decoupling the code OSBs pre-aligned with the satellite clocks; then satellite clocks are re-estimated by holding pre-resolved undifferenced ambiguities and phase OSBs on the baseline frequencies; finally, all third-frequency phase OSBs are determined by introducing the ambiguity-fixed satellite clocks above. We used a global network of multi-frequency GPS/Galileo data over a month to verify this approach. In dual-frequency PPP-AR using GPS L1/L2, L1/L5, Galileo E1/E5a, E1/E5b, E1/E5 and E1/E6 signals, over 95% of wide-lane and narrow-lane ambiguity residuals were within ±0.25 and ±0.15 cycles, respectively, after the code and phase OSB corrections on raw GNSS measurements. As a result, the ambiguity fixing rates reached around 95% in all PPP-AR tests, though it was only the satellite clocks aligned with the GPS L1/L2 and Galileo E1/E5a pseudorange that were applied throughout. We stress that the key to computing such phase OSBs for all-frequency PPP-AR is that the code OSBs have the same bias datum as that of the satellite clocks.
Pathogenic potential of bacteria isolated from commercial biostimulants
Authors: Bulgari Daniela , Filisetti Silvia , Montagna Matteo , Gobbi Emanuela , Faoro Franco 
Published: February 2022

AbstractMicrobial-based products are a promising alternative to agrochemicals in sustainable agriculture. However, little is known about their impact on human health even if some of them, i.e., Bacillus and Paenibacillus species, have been increasingly implicated in different human diseases. In this study, 18 bacteria were isolated from 2 commercial biostimulants, and they were genotypically and phenotypically characterized to highlight specific virulence properties. Some isolated bacteria were identified as belonging to the genus Bacillus by BLAST and RDP analyses, a genus in-depth studied for plant growth-promoting ability. Moreover, 16S rRNA phylogenetic analysis showed that seven isolates grouped with Bacillus species while two and four clustered, respectively, with Neobacillus and Peribacillus. Unusually, bacterial strains belonging to Franconibacter and Stenotrophomonas were isolated from biostimulants. Although Bacillus species are generally considered nonpathogenic, most of the species have shown to swim, swarm, and produced biofilms, that can be related to bacterial virulence. The evaluation of toxins encoding genes revealed that five isolates had the potential ability to produce the enterotoxin T. In conclusion, the pathogenic potential of microorganisms included in commercial products should be deeply verified, in our opinion. The approach proposed in this study could help in this crucial step.
Clinical Utility and Characteristics of the LARS Score Compared to the CCIS
Authors: Akizuki Emi , Okita Kenji , Noda Ai , Tsuruma Tetsuhiro , Nishimori Hidefumi , Sasaki Kenichi , Kimura Masami , Nishidate Toshihiko , Okuya Koichi , Hamabe Atsushi , Ishii Masayuki , Takemasa Ichiro 
Published: February 2022

AbstractPurposeThe low anterior resection syndrome (LARS) score (LS) has been widely validated and has become an international tool for evaluating postoperative bowel dysfunction. However, many physicians still use the conventional incontinence scores in LARS treatment. Moreover, interpretation of LS and its relationship with conventional incontinence scores are not yet well understood. Here we compared the LS with the Cleveland Clinic Incontinence Score (CCIS) to clarify the clinical utility and characteristics of the LARS score.MethodsWe performed a multicentre observational study, recruiting 246 rectal cancer patients following sphincter‐preserving surgery. Patients completed the LS, CCIS, and SF36 questionnaires.ResultsThe response rate was 76.4%, and a total of 180 patients were analysed. The LS was strongly correlated with the CCIS (P < 0.001, rs = 0.727). However, among 116 patients determined to not have incontinence (CCIS 0–5), 51 (44%) were diagnosed with LARS (29 with minor LARS and 22 with major LARS). Among 68 patients without LARS, only 3 were diagnosed as having incontinence (CCIS > 6). In comparison with background factors, aging and elapsed time were associated with only LS. High LS and CCIS both showed significant quality‐of‐life impairment as assessed by the SF‐36.ConclusionThis is the first study to determine the difference in the numeric values between the CCIS and LS. The LS can be a convenient tool for LARS screening, identifying a wide range of patients with LARS, including those with incontinence evaluated by CCIS. Assessment using the CCIS may often underestimate LARS.
Long‐Term Outcome of Patients with Postoperative Refractory Diarrhea After Tailored Nerve Plexus Dissection Around the Major Visceral Arteries During Pancreatoduodenectomy for Pancreatic Cancer
Authors: Kuroki Naomi , Ono Yoshihiro , Sato Takafumi , Inoue Yosuke , Oba Atsushi , Ito Hiromichi , Mise Yoshihiro , Saiura Akio , Takahashi Yu 
Published: February 2022

AbstractBackgroundFor pancreatic ductal adenocarcinoma (PDAC) surgery, extended dissection of the nerve plexus (pl) around the superior mesenteric artery (SMA) or celiac artery (CA) is sometimes necessary. This consequently results in postoperative refractory diarrhea. This study aimed to evaluate the clinical impact of extended nerve plexus dissection around major arteries on postoperative diarrhea.MethodsPatients who underwent pancreatoduodenectomy (PD) for PDAC between January 2013 and December 2016 were included. The frequency of diarrhea (defined as a condition requiring opioid antidiarrheal drug for at least 6 months after surgery) and its short‐ and long‐term outcomes were reviewed.ResultsOf 200 consecutive patients who underwent PD, 78 (39.0%) developed postoperative refractory diarrhea (diarrhea group), and 73 of them (93.6%) underwent hemi‐circumferential or more nerve dissection for SMA or CA; both plSMA and plCA dissection were associated with diarrhea. Borderline resectable artery (BR‐A) PDAC was included more in the diarrhea group (32.0% vs. 13.1%, P = 0.001); however, the local recurrence rate in the diarrhea group was significantly lower than that in the non‐diarrhea group (14.1% vs. 26.2%, P = 0.036). The completion of adjuvant chemotherapy and overall survival were comparable between the two groups. The pre‐albumin level improved in 2 years, and 61.3% of patients with diarrhea could stop opioid antidiarrheal drugs within 3 years of surgery.ConclusionsAlthough the frequency of diarrhea increased following nerve plexus dissection around arteries, diarrhea was controllable and resulted in a reduced local recurrence rate. Aggressive dissection of the nerve plexus may be justified for local disease control in BR‐A PDAC.
Randomized Phase 3 LEAP-012 Study: Transarterial Chemoembolization With or Without Lenvatinib Plus Pembrolizumab for Intermediate-Stage Hepatocellular Carcinoma Not Amenable to Curative Treatment
Authors: Llovet Josep M. , Vogel Arndt , Madoff David C. , Finn Richard S. , Ogasawara Sadahisa , Ren Zhenggang , Mody Kalgi , Li Jerry J. , Siegel Abby B. , Dubrovsky Leonid , Kudo Masatoshi 
Published: February 2022

Abstract
Purpose
Transarterial chemoembolization (TACE) is the standard of care for patients with intermediate-stage hepatocellular carcinoma (HCC). Lenvatinib, a multikinase inhibitor, and pembrolizumab, a PD-1 inhibitor, have shown efficacy and tolerability in patients with HCC, and adding this combination to TACE may enhance clinical benefit.

Protocol
LEAP-012 is a prospective, double-blind randomized phase 3 study. Adults with confirmed HCC localized to the liver without portal vein thrombosis and not amenable to curative treatment, ≥ 1 measurable tumor per Response Evaluation Criteria in Solid Tumors 1.1 (RECIST 1.1), Eastern Cooperative Oncology Group performance status 0 or 1, Child–Pugh class A and no previous systemic treatment for HCC are eligible. Patients will be randomly assigned to lenvatinib once daily plus pembrolizumab every 6 weeks plus TACE or placebos plus TACE. Dual primary endpoints are overall survival and progression-free survival per RECIST 1.1 by blinded independent central review (BICR). Secondary endpoints are progression-free survival, objective response rate, disease control rate, duration of response and time to progression per modified RECIST by BICR; objective response rate, disease control rate, duration of response and time to progression per RECIST 1.1 by BICR; and safety.

Statistics
The planned sample size, 950 patients, was calculated to permit accumulation of sufficient overall survival events in 5 years to achieve 90% power for the overall survival primary endpoint.

Discussion
LEAP-012 will evaluate the clinical benefit of adding lenvatinib plus pembrolizumab to TACE in patients with intermediate-stage HCC not amenable to curative treatment.
ClinicalTrials.gov NCT04246177.
Individualized arterial spin labeling background suppression by rapid T1 mapping during acquisition
Authors: Lindner T. , Guerreiro H. , Austein F. , Fiehler J. 
Published: February 2022

Abstract
Objective
Arterial spin labeling blood perfusion signal relies on the difference between a label and a control image. Background suppression pulses are commonly used to improve the contrast, yet these are based on estimates of tissue relaxation times. The aim of this study is to improve the perfusion contrast by individualizing the timing of these background suppression pulses by means of T1 mapping.

Methods
The optimized timing of the background suppression pulses is obtained by rapid T1 mapping employing the variable flip angle technique. Ten healthy volunteers were included in this study. To compare the results, visual grading and the Wilcoxon signed-rank test was used comparing three categories of image quality.

Results
The readers confirmed that the images of the proposed method generally show a higher signal-to-background ratio and cortical structures are better visible. Noise was mostly comparable to the standard method. Relative blood flow was statistically significant higher in the modified method.

Conclusion
The individually optimized background suppression pulses improve the image appearance and allow for a better visualization of cortical structures. The proposed technique however prolongs scan time, which can be seen as negative result, yet needs to be further evaluated.

Key Points
• Background suppression timing in ASL can vary.
• Both the label and control condition can be modified for T1 mapping.
• Adapting the pulse timing improves the signal-to-background ratio.
Prospective association between dietary magnesium intake and physical performance in older women and men
Authors: Arias-Fernández Lucía , Struijk Ellen A. , Caballero Francisco Félix , Ortolá Rosario , García-Esquinas Esther , Rodríguez-Artalejo Fernando , Lopez-Garcia Esther , Lana Alberto 
Published: February 2022

Abstract
Purpose
Magnesium is a profuse intracellular cation with a key role in muscle function and cellular senescence. The aim was to examine the prospective association between 5 year changes in dietary intake of magnesium and changes in physical performance among older men and women.

Methods
Prospective study conducted over 863 community-dwellers aged ≥ 65 years from the Seniors-ENRICA cohort (Spain). In 2012 and 2017, a validated computerized face-to-face diet history was used to record the consumption of up to 880 foods. From these data, we estimated changes in dietary magnesium intake. The Short Physical Performance Battery (SPPB) was also conducted in both time points and we obtained changes in the score during follow-up, with positive values indicating physical performance improvement.

Results
Over 5 years of follow-up, an increase in magnesium intake was associated with an increment in the SPPB score among older women [multivariate β (95% confidence interval): 1.01 (0.49; 1.52), p-trend: 0.001]. In addition, changes from non-adherence to adherence to both estimated average requirement and recommended dietary allowance during follow-up period were associated with an increment in SPPB score among older women [1.14 (0.36; 1.92) and 0.84 (0.22; 1.47), respectively]. No significant associations between changes in magnesium intake and changes in SPPB score were observed in men.

Conclusions
Both increase of magnesium intake and change from non-adherence to adherence to dietary reference magnesium intake was prospectively associated with better physical performance among older women, but not among men.
Prognostic value and management of regional lymph nodes in locoregional breast cancer recurrence: a systematic review of the literature
Authors: Ge Isabell , Erbes Thalia , Juhasz-Böss Ingolf 
Published: February 2022

Abstract
Purpose
Management of regional lymph nodes in breast cancer recurrence has been heterogeneous. To facilitate clinical practice, this review aims to give an overview on the prognosis, staging and operative management of (inapparent) regional lymph nodes.

Methods
Current national and international guidelines are reviewed and a structured search of the literature between Jan 1, 1999 and Feb 1, 2021 on the repeat sentinel node biopsy (re-SNB) procedure was performed.

Results
Positive regional lymph nodes in recurrent breast cancer indicate a poorer outcome with axillary recurrences being the most favorable tumor site among all nodal regions. Most preferred staging method is ultrasound ± guided biopsy. PET-CT, scintimammography, SPECT-CT may improve visualization of affected lymph nodes outside the axilla. Concerning operative management 30 articles on re-SNB were identified with a mean harvesting rate of 66.4%, aberrant drainage and aberrant metastasis in 1/3 of the cases. Total rate of metastasis is 17.9%. After previous axillary dissection (ALND) the re-SNB has a significantly lower harvesting rate and higher aberrant drainage and aberrant metastasis rate. The prognostic outcome after re-SNB has been favorable.

Conclusion
Nodal status in recurrent disease has prognostic value. The choice of operative management of clinically inapparent regional lymph nodes during local recurrence should be based on the previous nodal staging method. Patients with previous ALND should be spared a second systematic ALND. Re-SNB or no axillary surgery at all are possible alternatives. Lymphoscintigraphy may be performed to identify extraaxillary drainage. However, for definite recommendations randomized controlled studies are heavily needed.
An integrated TMS-EEG and MRI approach to explore the interregional connectivity of the default mode network
Authors: Esposito Romina , Bortoletto Marta , Zacà Domenico , Avesani Paolo , Miniussi Carlo 
Published: February 2022

AbstractExplorations of the relation between brain anatomy and functional connections in the brain are crucial for shedding more light on network connectivity that sustains brain communication. In this study, by means of an integrative approach, we examined both the structural and functional connections of the default mode network (DMN) in a group of sixteen healthy subjects. For each subject, the DMN was extracted from the structural and functional resonance imaging data; the areas that were part of the DMN were defined as the regions of interest. Then, the target network was structurally explored by diffusion-weighted imaging, tested by neurophysiological means, and retested by means of concurrent transcranial magnetic stimulation and electroencephalography (TMS-EEG). A series of correlational analyses were performed to explore the relationship between the amplitude of early-latency TMS-evoked potentials and the indexes of structural connectivity (weighted number of fibres and fractional anisotropy). Stimulation of the left or right parietal nodes of the DMN-induced activation in the contralateral parietal and frontocentral electrodes within 60 ms; this activation correlated with fractional anisotropy measures of the corpus callosum. These results showed that distant secondary activations after target stimulation can be predicted based on the target’s anatomical connections. Interestingly, structural features of the corpus callosum predicted the activation of the directly connected nodes, i.e., parietal-parietal nodes, and of the broader DMN network, i.e., parietal-frontal nodes, as identified with functional magnetic resonance imaging. Our results suggested that the proposed integrated approach would allow us to describe the contributory causal relationship between structural connectivity and functional connectivity of the DMN.
Determinants of antibiotic prescriptions in a large cohort of children discharged from a pediatric emergency department
Authors: Covino Marcello , Buonsenso Danilo , Gatto Antonio , Morello Rosa , Curatole Antonietta , Simeoni Benedetta , Franceschi Francesco , Chiaretti Antonio 
Published: February 2022

AbstractWhile there is evidence of high use of wide-spectrum antibiotics in children evaluated in the pediatric emergency departments, determinants of this behavior are still unclear. This study was aimed at defining the demographic, social, clinical, and laboratory factors that affect antibiotic prescriptions in children discharged from the emergency department. We performed a retrospective observational study of children aged younger than 18 years discharged from a pediatric university hospital between Jan. 1, 2015 and Dec. 31, 2020. We determined the proportion and type of antibiotic prescription according to demographic, social, clinical, laboratory, and imaging data, as well as doctor’s expertise. Fifty-one thousand six hundred thirty-three children were included, and 13,167 (25.5%) received an antibiotic prescription. Amoxicilline/clavulanate (Am/Cl) was the most prescribed antibiotic (8453, 64.2% of all prescriptions). Factors independently associated with an antibiotic prescription were older age (OR = 1.62 [1.53–1.73] for age 2–5 years, OR = 1.77 [1.64–1.91] for age 6–10 years, OR = 1.36 [1.25–1.49] for age 11–18 years, p < 0.001 for all groups); being evaluated by a physician with > 3 years of pediatric expertise (OR = 1.22 [1.13–1.31], p < 0.001); fever peak higher than 40 °C (OR = 1.37 [1.21–1.54], p < 0.001); abnormal findings on auscultation (OR = 1.95 [1.75–2.17], p < 0.001), CRP values (OR = 1.63 [1.26–2.10] for CRP < 50 mg/L, and OR = 3.78 (2.75–5.21) for CRP ≥ 50 mg/L with respect to CRP not requested; p < 0.01); CXR results whatever positive (OR = 4.47 [3.62–5.52], p < 0.001) or negative (1.82 [1.62–2.04], p < 0.001); being diagnosed with upper respiratory tract infections (OR = 4.27 [4.04–4.51], p < 0.001), lower respiratory tract infections (OR = 5.35 [4.88–5.85]; p < 0.001), and UTI (OR = 9.33 [8.14–10.71], p < 0.001). Conclusions: Overprescription of antibiotics, including Am/Cl, is relevant in pediatric emergency departments. Factors associated with overprescription are not limited to the clinical characteristics of the treated patients. These findings highlight the need for a new and comprehensive approach to ensure successful antibiotic stewardship initiatives in the emergency departments.

What is Known:• Antibiotic resistance is a growing problem in medical practice, including in pediatrics.• Antibiotics are overprescribed in children assessed in the emergency department, but comprehensive and large studies are lacking.

What is New:• Factors associated with overprescription are not limited to the clinical characteristics of the patients.• Non-clinical factors such as environmental variables, doctor’s expertise, and attitudes to laboratory and radiological examinations affect prescription.
Parasitic threat in commercial organic fertilizers
Authors: Figura Aleksandra , Cencek Tomasz , Żbikowska Elżbieta 
Published: February 2022

AbstractThe use of fertilizers based on sewage sludge is common practice. Due to the possible presence of pathogens and eggs of intestinal parasites like Ascaris sp., Toxocara sp., and Trichuris sp. in these products, it is necessary to control them. The aim of the study was to determine the presence of parasite eggs in commercial organic fertilizers available on the market. Selected commercial products were tested using the Quinn flotation method and a method dedicated to the study of dewatered sewage sludge. Assessment of the viability of helminth eggs was carried out on the basis of staining with calcein and propidium iodide. In 57% of the tested samples, the presence of live eggs of the abovementioned parasites was detected, and in 21% of samples, the eggs with live larvae were detected. Eggs of Trichuris sp. (50%) and Ascaris sp. (36%) were the most common. The obtained results clearly indicate that the process of hygienization of the sewage sludge before the production of fertilizers was not effective enough and it is necessary to standardize the prophylaxis against the spread of parasitic nematodes in commercially available products.
Intracaldera explosions and lava emissions during the 2007 caldera collapse of Piton de la Fournaise, La Réunion Island
Authors: Vergani Daniele , McPhie Jocelyn , Carey Rebecca , Di Muro Andrea 
Published: February 2022

AbstractThe March–April 2007 Piton de la Fournaise basaltic eruption was the most significant eruption on La Réunion Island in historical times. On 2 April, a fissure opened on the southeastern flank of the volcano. Vigorous fountains fed lavas that rapidly reached the coast. Three days later, on the 5–6 April, major caldera collapse occurred at the summit, affecting the floor and walls of Dolomieu caldera. Monitoring records, primarily webcam images, have been analysed and integrated with geophysical data to reconstruct the chronology of events at the summit during caldera collapse. Those events included progressive subsidence of the former caldera floor, landslides, explosions, lava emissions and steam fumaroles, and lasted until 19 April though diminished greatly in frequency after 7 April. For two days after the main caldera collapse on 5 April, subsidence increments, intracaldera lava emission and explosions were closely associated in time and in location. Abundant steam and wet talus on the caldera walls imply that the shallow hydrothermal system and/or groundwater were exposed by subsidence. The presence of juvenile components in ash deposited at the summit during caldera collapse and the close link between intracaldera lavas and explosions suggest that many explosions were phreatomagmatic. Although caldera collapse was related to magma withdrawal from beneath the summit via the flank vent activity, numerous intracaldera lava emissions indicated that magma was nevertheless present at the summit during caldera collapse. We infer that the lava emissions were fed by an intrusion emplaced at the end of March into the eastern summit region and that the intrusion was being actively recharged during caldera collapse. Caldera collapse involved a complex combination of magma withdrawal and magma replenishment at separate summit reservoirs.