bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene–environment interplay in externalizing behavior from childhood through adulthood
Authors: Kretschmer Tina , Vrijen Charlotte , Nolte Ilja Maria , Wertz Jasmin , Hartman Catharina Annette 
Published: June 2022

BackgroundGenetic and environmental influences on externalizing problems are often studied separately. Here, we extended prior work by investigating the implications of gene–environment interplay in childhood for early adult externalizing behavior. Genetic nurture would be indicated if parents' genetic predisposition for externalizing behavior operates through the family environment in predicting offspring early adult externalizing behavior. Evocative gene–environment correlation would be indicated if offspring genetic predisposition for externalizing behavior operates through child externalizing behavior in affecting the family environment and later early adult externalizing behavior.MethodLongitudinal data from seven waves of the TRacking Adolescents' Individual Lives Survey, a prospective cohort study of Dutch adolescents followed from age 11 to age 29 (n at baseline = 2,734) were used. Child externalizing behavior was assessed using self and parent reports. Family dysfunction was assessed by parents. Early adult externalizing behavior was assessed using self‐reports. Genome‐wide polygenic scores for externalizing problems were constructed for mothers, fathers, and offspring.ResultsOffspring polygenic score and child behavior each predicted early adult externalizing problems, as did family dysfunction to a small extent. Parents' polygenic scores were not associated with offspring's early adult externalizing behavior. Indirect effect tests indicated that offspring polygenic score was associated with greater family dysfunction via child externalizing behavior (evocative gene–environment correlation) but the effect was just significant and the effect size was very small. Parents' polygenic scores did not predict family dysfunction, thus the data do not provide support for genetic nurture.ConclusionsA very small evocative gene–environment correlation was detected but effect sizes were much more pronounced for stability in externalizing behavior from childhood through early adulthood, which highlights the necessity to intervene early to prevent later problems.
UpdatedS2K guidelines for the management of bullous pemphigoid initiated by the European Academy of Dermatology and Venereology (EADV)
Authors: Borradori L. , Van Beek N. , Feliciani C. , Tedbirt B. , Antiga E. , Bergman R. , Böckle B. C. , Caproni M. , Caux F. , Chandran N.S. , Cianchini G. , Daneshpazhooh M. , De D. , Didona D. , Di Zenzo G. M. , Dmochowski M. , Drenovska K. , Ehrchen J. , Goebeler M. , Groves R. , Günther C. , Horvath B. , Hertl M. , Hofmann S. , Ioannides D. , Itzlinger‐Monshi B. , Jedličková J. , Kowalewski C. , Kridin K. , Lim Y. L. , Marinovic B. , Marzano A. V. , Mascaro J.‐M. , Meijer J.M. , Murrell D. , Patsatsi K. , Pincelli C. , Prost C. , Rappersberger K. , Sárdy M. , Setterfield J. , Shahid M. , Sprecher E. , Tasanen K. , Uzun S. , Vassileva S. , Vestergaard K. , Vorobyev A. , Vujic I. , Wang G. , Wozniak K. , Yayli S. , Zambruno G. , Zillikens D. , Schmidt E. , Joly P. 
Published: June 2022

AbstractBackgroundBullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of the skin and mucous membranes. This disease typically affects the elderly and presents with itch and localized or, most frequently, generalized bullous lesions. A subset of patients only develops excoriations, prurigo‐like lesions, and eczematous and/or urticarial erythematous lesions. The disease, which is significantly associated with neurological disorders, has high morbidity and severely impacts the quality of life.Objectives and methodologyThe Autoimmune blistering diseases Task Force of the European Academy of Dermatology and Venereology sought to update the guidelines for the management of BP based on new clinical information, and new evidence on diagnostic tools and interventions. The recommendations are either evidence‐based or rely on expert opinion. The degree of consent among all task force members was included.ResultsTreatment depends on the severity of BP and patients' comorbidities. High‐potency topical corticosteroids are recommended as the mainstay of treatment whenever possible. Oral prednisone at a dose of 0.5 mg/kg/day is a recommended alternative. In case of contraindications or resistance to corticosteroids, immunosuppressive therapies, such as methotrexate, azathioprine, mycophenolate mofetil or mycophenolate acid, may be recommended. The use of doxycycline and dapsone is controversial. They may be recommended, in particular, in patients with contraindications to oral corticosteroids. B‐cell‐depleting therapy and intravenous immunoglobulins may be considered in treatment‐resistant cases. Omalizumab and dupilumab have recently shown promising results. The final version of the guideline was consented to by several patient organizations.ConclusionsThe guidelines for the management of BP were updated. They summarize evidence‐ and expert‐based recommendations useful in clinical practice.
Temporal increase of Varroa mites in trap frames used for drone brood removal during the honey bee season
Authors: Odemer Richard , Odemer Franziska , Liebig Gerhard , de Craigher Doris 
Published: June 2022

AbstractVarroa mites are highly attracted to drone brood of honey bees (Apis mellifera), as it increases their chance of successful reproduction. Therefore, drone brood removal with trap frames is common practice among beekeepers in Europe and part of sustainable varroa control. However, it is considered labour‐intensive, and there are doubts about the effectiveness of this measure. At present, it is mostly unknown how many mites a drone frame can carry at different times of the season, and how many mites can be removed on average if this measure is performed frequently. Therefore, we sampled a total of 262 drone frames with varying proportion of capped cells (5–100%) from 18 different apiaries. Mites were washed out from brood collected from mid‐April to mid‐July based on a standard method to obtain comparable results. We found that a drone frame carried a median of 71.5 mites, and with the removal of four trap frames, about 286 mites can be removed per colony and season. In addition, mite counts were significantly higher in June and July than in April and May (Tukey‐HSD, P < 0.05). The number of mites and the proportion of capped cells, however, were not correlated (R2 < 0.01, P < 0.05). Our results suggest that drone brood removal is effective in reducing Varroa destructor numbers in colonies, supporting the findings of previous studies on the efficacy of this measure. Although mite counts varied, we believe that increasing sample size over different seasons and locations could elucidate infestation patterns in drone brood and ultimately improve drone brood removal as an integrated pest management tool for a wider audience of beekeepers.
The credit channel of monetary policy before and after the zero lower bound: Evidence from the US equity market
Authors: Farka Mira 
Published: June 2022

AbstractI evaluate the effectiveness of conventional and unconventional monetary policy measures by examining the transmission mechanism through the credit channel before and after the zero lower bound (ZLB). I focus on the impact of conventional and unconventional policy shocks on a cross‐section of portfolio returns sorted on characteristics that capture firms' financial constraints (size and book‐to‐market). Results show that the credit channel of monetary policy is even more relevant at the ZLB relative to the previous period, and its effectiveness is almost entirely attributed to the high sensitivity of financially constrained firms (small and value stocks) to unconventional surprises. I find strong evidence that the reaction of portfolio returns to policy shocks is asymmetric depending on the state of the economy (recession vs. expansion), type of policy surprise (positive vs. negative), and aggregate level of market volatility. My findings are robust to several model extensions and alternative specifications.
Parental consideration of children's experiences: A critical review of parenting constructs
Authors: Joussemet Mireille , Grolnick Wendy S. 
Published: June 2022

AbstractThe purpose of this paper is to bring together and highlight common conceptual elements and findings from constructs that involve parents' consideration of children's viewpoints and experiences: parental sensitivity, empathy, perspective taking, responsiveness, autonomy support, and scaffolding. Research on each of these constructs suggests that consideration in the parenting role is associated with better child development, learning, and well‐being. We examine definitions and measures of the constructs to address how parental consideration has been conceptualized. We also review positive child development indicators that have been associated with it, across various periods, contexts, and domains of development. By drawing attention to this common denominator and adopting an integrative perspective, we hope to contribute to future research and help transfer knowledge to parents about this key, facilitative parenting dimension.
Dementia prevalence, a contextual factor associated with SARS‐CoV‐2 in veterans affairs community living centers
Authors: Bayer Thomas A. , DeVone Frank , McConeghy Kevin W. , Halladay Christopher W. , Quach Lien , Rajan Ashna , Elhamamsy Salaheldin , Cadieux Marilyne , Singh Mriganka , Sachar Moniyka , Nanda Aman , Gravenstein Stefan , Rudolph James L. 
Published: June 2022

AbstractBackgroundAlzheimer's disease and related dementias (ADRD) impact the diagnosis and infection control of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) in nursing homes (NH) by influencing the behavior of residents and their caregivers. Health system data show an association between ADRD and SARS‐CoV‐2. Whether this association is present in NH populations remains unknown. How increased SARS‐CoV‐2 risk among residents with ADRD impacts the greater NH population also remains unknown.MethodsThis retrospective cohort study used electronic health record data on Veterans residing in 133 Veterans Affairs Community Living Centers (CLC) and 15 spinal cord injury units from March 1, 2020 to December 13, 2020. We measured ADRD using diagnostic codes 12 months before an index SARS‐CoV‐2 test date for each resident. We used Poisson regression to determine the relative risk of SARS‐CoV‐2 for the highest quartile of facility ADRD prevalence versus the lowest, stratifying by individual ADRD status, and adjusting for covariates, with and without a random intercept to account for facility clustering.ResultsAcross the study period, 15,043 residents resided in CLCs, 1952 (13.0%) had SARS‐CoV‐2, and 8067 (53.6%) had ADRD. There was an estimated 60% increased risk of SARS‐CoV‐2 in facilities with highest dementia prevalence versus lowest (relative risk, 1.6 [95% confidence interval 0.95, 2.7]).ConclusionsCLC residents had a greater likelihood of SARS‐CoV‐2 infection in facilities with greater ADRD prevalence. Facility characteristics other than ADRD prevalence may account for this association.
The divergence of brassinosteroid sensitivity between rice subspecies involves natural variation conferring altered internal auto‐binding of OsBSK2
Authors: Yin Wenchao , Li Lulu , Yu Zhikun , Zhang Fan , Liu Dapu , Wu Hongkai , Niu Mei , Meng Wenjing , Zhang Xiaoxing , Dong Nana , Yang Yanzhao , Liu Jihong , Liu Yongqiang , Zhang Guoxia , Xu Jianlong , Wang Shimei , Chu Chengcai , Qian Qian , Tong Hongning 
Published: June 2022

ABSTRACTJaponica/geng and indica/xian are two major rice (Oryza sativa) subspecies with multiple divergent traits, but how these traits are related and interact within each subspecies remains elusive. Brassinosteroids (BRs) are a class of steroid phytohormones that modulate many important agronomic traits in rice. Here, using different physiological assays, we revealed that japonica rice exhibits an overall lower BR sensitivity than indica. Extensive screening of BR signaling genes led to the identification of a set of genes distributed throughout the primary BR signaling pathway with divergent polymorphisms. Among these, we demonstrate that the C38/T variant in BR Signaling Kinase2 (OsBSK2), causing the amino acid change P13L, plays a central role in mediating differential BR signaling in japonica and indica rice. OsBSK2L13 in indica plays a greater role in BR signaling than OsBSK2P13 in japonica by affecting the auto‐binding and protein accumulation of OsBSK2. Finally, we determined that OsBSK2 is involved in a number of divergent traits in japonica relative to indica rice, including grain shape, tiller number, cold adaptation, and nitrogen‐use efficiency. Our study suggests that the natural variation in OsBSK2 plays a key role in the divergence of BR signaling, which underlies multiple divergent traits between japonica and indica.
Tectonic erosion and deep subduction in Central Tibet: Evidence from the discovery of retrograde eclogites in the Amdo microcontinent
Authors: Peng Yinbiao , Yu Shengyao , Li Sanzhong , Liu Yongjiang , Santosh M. , Lv Pei , Li Yunshuai , Li Chuanzhi , Liu Yiming 
Published: June 2022

AbstractThe Amdo microcontinent which separates the Qiangtang terrane to the north and the Lhasa terrane to the south is a key terrane for reconstructing the tectonic evolution of Central Tibet. We report the new finding of retrograde eclogites within the Amdo microcontinent in this study. The eclogites are characterized by peak metamorphic mineral assemblages of garnet, omphacite, rutile and quartz and underwent a four‐stage metamorphic evolution, including a peak eclogite facies stage (M1) at ~20–24 kbar and 580–620°C, followed by an HP granulite facies decompression stage (M2) at ~13–15 kbar and 750–780°C, a subsequent MP‐UHT granulite facies heating stage (M3) at 8–10 kbar and >840°C and a final amphibolite facies retrogression (M4) at 5.3–6.0 kbar and 560–580°C. The eclogites exhibit rare earth element distribution patterns and trace element abundances similar to those of N‐MORB and arc‐related volcanics, with depleted whole‐rock εNd(t) values of 3.4 to 4.2, and are inferred to have formed in a back‐arc basin tectonic setting. Zircon and rutile U–Pb dating yields a protolith age of 226 ± 5 Ma, a peak eclogite facies metamorphic age of 190 ± 1 Ma, an HP granulite facies metamorphic age of 179 ± 1 Ma and an amphibolite facies retrograde age of 172 ± 1 Ma. The clockwise P–T–t paths and the oceanic protolith signature of retrograde eclogites suggest that part of the back arc basin was subducted to depths of ~80 km. Tectonic erosion associated with the subduction of the Amdo microcontinent beneath the Tethys Ocean accounts for the deep subduction of the back‐arc basin and the absence of arc magmatic rocks in the northern Amdo microcontinent.
Investigating the association of mood and fatigue with objective and subjective cognitive impairment in multiple sclerosis
Authors: Davenport Laura , Cogley Clodagh , Monaghan Ruth , Gaughan Maria , Yap Mei , Bramham Jessica , Tubridy Niall , McGuigan Chris , O'Keeffe Fiadhnait 
Published: June 2022

AbstractDiscrepancies between subjective cognitive difficulties and objective measures of cognitive function in people with MS have been identified and may be related to mood and fatigue. The aim of the present study was to examine associations of depression and fatigue with discrepancies between subjective and objective cognitive functioning in pwMS. 177 participants with MS attending a University Hospital Department of Neurology MS Outpatient clinic completed the Brief International Cognitive Assessment for MS (BICAMS), MS Neuropsychological Questionnaire (MSNQ), Hospital Anxiety and Depression Scale (HADS) and Modified Fatigue Impact Scale (MFIS). To quantify the discrepancy between objective (BICAMS) and subjective (MSNQ) cognitive functioning, discrepancy scores were calculated by subtracting MSNQ z‐score from composite BICAMS z‐score. Based on their discrepancy score, participants were grouped as ‘Underestimated’, ‘Overestimated’ and ‘Non‐discrepant’. 39% of the total sample demonstrated poorer subjective cognitive functioning than their objective cognitive performance suggested (‘Underestimated’). 23% of the total sample indicated lower objective scores than their subjective report suggests (‘Overestimated’). 38% participants indicated relatively no discrepancy between objective and subjective cognitive measures (‘Non‐discrepant’). Significant differences were observed between the discrepancy groups in terms of depression and fatigue, with the ‘Underestimated’ group demonstrating greater levels of depression and fatigue (ps < .01). Regression analysis indicated that cognitive fatigue and depression significantly contributed to variance in subjective cognitive functioning. Our findings suggest that subjective reports of cognitive function may be influenced by depression and fatigue, emphasising the importance of cognitive, mood and fatigue screening as part of routine clinical care.
The regulatory role of HOX interacting lncRNA in oral cancer—An in silico analysis
Authors: Basavarajappa Dhanraj Salur , Padam Kanaka Sai Ram , Chakrabarty Sanjiban , AN Naveena Kumar , Radhakrishnan Raghu 
Published: June 2022

AbstractObjectivesWe aim to elucidate the interaction of long noncoding RNAs with HOX genes and their regulatory role and potential drug candidates in oral cancer.Materials and MethodsThe interaction network was constructed using RNA Interactome and the RNA Interactome from the Sequencing Experiments database. The differential expression of HOX genes and HOX interacting lncRNAs was assessed using the TCGA‐Head and Neck Squamous Cell Carcinoma oral cancer dataset using DESeq2 R‐package. Further, the functional enrichment analysis was performed for the differentially expressed HOX genes and HOX‐interacting lncRNAs using Gene Ontology, long noncoding RNA Set Enrichment Analysis, lncRNA ontology annotation extractor and repository (Lantern), and LncRNA Ontology tools. Drug‐lncRNA interaction and the effect of drugs on lncRNA expression were assessed from the D‐lnc tool.ResultsA total of 78 unique interactions were identified between HOX and lncRNAs. Differential expression analysis showed 27 HOX genes and 10 HOX‐interacting lncRNAs in oral cancer. HOX genes and HOX‐interacting lncRNAs were involved in crucial regulatory processes like cell cycle regulation, cell proliferation and migration, epithelial‐mesenchymal transition, angiogenesis, and cell signaling pathways. Cancer hallmark analysis from using long noncoding RNA Set Enrichment Analysis showed the involvement of HOTAIR, HOTTIP MIR503HG, and CDKN2B‐AS1 in proliferation, migration, and invasion. Panobinostat was the common drug that influenced the expression of HOTAIR, HOTAIRM1, HOTTIP and CDKN2B‐AS1.ConclusionsDifferentially expressed HOX‐interacting lncRNAs are involved in various regulatory biological processes and cancer hallmark events in oral cancer.Clinical RelevanceThe creation of interaction networks may expand the existing knowledge of oral cancer signaling pathways and the discovery of novel targets.
Antibody deposition on vascular endothelial cells contributes to localized inflammation in salivary glands
Authors: Bagavant Harini , Trzeciak Marta , Biswas Indranil , Papinska Joanna A. , Cizio Katarzyna , Deshmukh Umesh S. 
Published: June 2022

AbstractBackgroundOral and ocular dryness due to reduced saliva and tear production, exocrine gland inflammation, and autoantibodies to multiple cellular proteins are the cardinal features of Sjögren's Disease. Among the autoantibody specificities, anti‐Ro52 is linked with higher disease severity. We have previously reported that mice immunized with recombinant Ro52 developed IgG deposits in salivary and lacrimal glands and showed reduced saliva and tear production. Furthermore, passive transfer of sera from Ro52‐immunized mice rapidly induced glandular dysfunction without immune cell infiltration in recipient mice.MethodsTo identify mechanisms driving antibody‐mediated salivary gland dysfunction, hyperimmune rabbit antiserum to mouse Ro52 was passively transferred into NZM2758 female mice, pretreated with alum adjuvant. Alum‐pretreated mice given hyperimmune rabbit antiserum to maltose‐binding protein served as controls. Antibody deposition and its distribution in the salivary glands were studied by immunofluorescence staining for rabbit IgG, nerve fibers, and endothelial cells. The nCounter inflammation panel was used to determine differentially expressed genes in the salivary gland.ResultsRabbit IgG deposits were detected in salivary glands of anti‐Ro52 immune sera recipients. The rabbit IgG was present on the endothelial cells in small blood vessels, and it did not co‐localize with nerve fibers. Ingenuity pathway analysis of the gene expression dataset predicted the canonical vascular endothelial growth factor (VEGF) pathway as the most activated and Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) as the most inhibited pathway in the salivary glands of anti‐Ro52 sera recipients.ConclusionOur study suggests that autoantibody deposition on salivary gland endothelial cells might play a critical role in the pathogenesis of Sjögren's Disease.
Chasing up and locking down the virus: Optimal pandemic interventions within a network
Authors: Freiberger Michael , Grass Dieter , Kuhn Michael , Seidl Andrea , Wrzaczek Stefan 
Published: June 2022

AbstractDuring the COVID‐19 pandemic countries invested significant amounts of resources into its containment. In early stages of the pandemic most of the (nonpharmaceutical) interventions can be classified into two groups: (i) testing and identification of infected individuals, (ii) social distancing measures to reduce the transmission probabilities. Furthermore, both groups of measures may, in principle, be targeted at certain subgroups of a networked population. To study such a problem, we propose an extension of the SIR model with additional compartments for quarantine and different courses of the disease across several network nodes. We develop the structure of the optimal allocation and study a numerical example of three symmetric regions that are subject to an asymmetric progression of the disease (starting from an initial hotspot). Key findings include that (i) for our calibrations policies are chosen in a “flattening‐the‐curve,” avoiding hospital congestion; (ii) policies shift from containing spillovers from the hotspot initially to establishing a symmetric pattern of the disease; and (iii) testing that can be effectively targeted allows to reduce substantially the duration of the disease, hospital congestion and the total cost, both in terms of lives lost and economic costs.