bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pycnodysostosis- A Rare Diagnosis Not to Miss
Authors: Montasir Ahmed Al , Mondal Swapna Rani , Mustaque Ahmed - Al - , Shah Bipin 
Published: April 2022

Abstract
Background: there are several diseases that results repeated bone fracture. One of them is Pycnodysostosis. Pycnodysostosis was first described in 1962; however, the defective gene responsible for the skeletal features of Pycnodysostosis was discovered in 1996. Although genetic study confirms the diagnosis it’s not essential one to reach the clinical diagnosis. Several clinical features and radiological findings provide important clues to make the diagnosis in clinical settings.The Case: We made diagnosis of Pycnodysostosis in 67 years male who have typical suggestive clinical and radiological features. Our patient suffered from repeated fractures as the diagnosis was not made in early consultations with orthopaedic and primary healthcare facilities. He took NSAIDs since his childhood to alleviate pain of repeated fractures and mal-union. Pain and bony mal-union had made his quality of life very poor.Conclusion: We emphasize early diagnosis of this rare disorder and it can be easily made. Special care of Pycnodysostosis patients is needed to prevent fractures.
Recent trends in air temperature, precipitation and selected meteorological drough indices in the northern part of the Pannonian Plain and the adjacent Carpathian Mountains
Authors: Onderka Milan , Pecho Jozef 
Published: April 2022

Abstract
A total of 71 sites located within the northern part of the Pannonian Plain and the adjacent Carpathians were analysed for temporal trends in selected climate variables during the period 1981-2020. Because studying trends in quantiles may be more informative than just focusing on changes in long-term averages, quantile regression was used to quantify the temporal changes in precipitation totals, air temperature, climatic water balance, and two meteorological drought indices (SPI and SPEI) calculated for time scales ranging from 1 to 24 months. We identified a strong coupling between precipitation and local air temperature in the summertime and fall seasons. A reversed situation occurs in the case of springtime data, where a negative coupling between precipitation and temperature was observed. In addition, significant temporal changes in the z-score distributions of the investigated SPEI and SPI indices have been observed. The SPEI index has identified distinctive intensification of meteorological drought starting in the springtime season and continuing into early fall at the majority of the analyzed locations.
Analysis of public domain plant transcriptomes expands the phylogenetic diversity of the family Secoviridae
Authors: Sidharthan V. Kavi , Rajeswari V. , V.K.Baranwal  
Published: April 2022

Abstract
Secoviruses are mono-/bi-partite plant-infecting RNA viruses that cause economically important diseases in plants. In the present study, nine secoviruses tentatively named as Ananas comosus secovirus (AcSV), Artocarpus altilis secovirus (AaSV), Boehmeria nivea secovirus (BnSV), Gynostemma pentaphyllum secovirus (GpSV), Orobanche cernua secovirus (OcSV), Paris polyphylla secovirus 1 (PpSV1), Paris polyphylla secovirus 2 (PpSV2), Rhododendron delavayi secovirus (RdSV) and Yucca gloriosa secovirus (YgSV) were identified by analysis of publicly available transcriptomes of eight plant species. Coding-complete genome/genome segments of all the identified viruses encoding a polyprotein were recovered. Two of the identified viruses- AcSV and GpSV were discovered in few of the small RNA libraries of respective plant species. Putative cleavage sites were predicted in polyproteins encoded by AcSV, GpSV, PpSV2 and YgSV genome segments. Phylogenetic and sequence similarity analyses showed that AcSV, GpSV and YgSV, PpSV1 and RdSV putatively belong to the genera- Sadwavirus (sub genus: Cholivirus), Fabavirus, Nepovirus and Waikavirus, respectively while AaSV, BnSV and PpSV2 may represent a distinct group of viruses within the family Secoviridae as they could not certainly be assigned to a particular genera.
Pedunculated Lipofibroma in a pediatric patient.
Authors: Ahamad Mohammad Nafees , Guljabin  
Published: April 2022

Abstract
Pedunculated lipofibroma is a rare form of nevus lipomatosus cutaneous superficialis (NLCS). The lesions are large, slow-growing, pedunculated tumors, characterized histologically by ectopic adipose tissue in the dermis. A 9-year-old girl presented with a solitary painless cerebriform pedunculated mass over her right arm. Histopathological examination of the excised mass revealed lipofibroma. The solitary type of NLCS, or pedunculated lipofibroma, occurs usually over 20 years of age and is found on the axilla, knee, ear, or skin of the scalp. The striking finding, that the hamartoma had grown constantly in early life, from a small nodule to a large mass, is rare in pediatric age group so it’s been presented.
Atoms in Gaseous and Solid States and their Energy and Force Relationships under Transitional Behaviors
Authors: Ali Mubarak 
Published: April 2022

Abstract
By recalling the conventional studies of atoms, it is possible to discover new insights tackling the present and future challenges. The electrons and energy knots form atoms of different elements. In different elements, atoms are recognized based on the number of electrons and energy knots. Depending on how many filled and unfilled states in an atom of the element are allocated, the lattice is formed or constructed by intercrossing the overt photons having fixed lengths and numbers. In the intercrossing of the overt photons, the centers of the overt photons remained fixed at a common point. Gaseous atoms keep different schemes of intercrossing overt photons than solid atoms. Except for the hydrogen atom, the atoms possess the same valency as specified. Two electrons are occupied by the two energy knots in the hydrogen atom, whereas four electrons are occupied by the four energy knots in the helium atom. A helium atom is related to the zeroth ring in all higher-order atoms. In order to validate these statements above, the concept of considering protons and neutrons is no longer significant. As far as the gaseous atoms are concerned, electrons possess the minimum required potential energy. So, the electrons remain above the middle of occupied energy knots in the gaseous atoms for more than half the length, and they keep on experiencing the maximum required levitational force along the north pole. In solid atoms, electrons possess the maximum required potential energy. So, the electrons remain below the middle of occupied energy knots in the solid atoms in more than half the length, and they keep on experiencing the maximum required gravitational force along the south pole. Atoms undertake the transition states under the established relation of energy and force. In the transition, electrons of the atom deal with infinitesimal displacements by remaining within the occupied energy knots. The related orientational force keeps on exerting to the electrons introducing the recovery, neutral, re-crystallization, and liquid states for their atoms. In converting a gaseous atom into the liquid state, electrons left to the center of the atom orientate north to east clockwise, and electrons right to the center of the atom orientate north to west anti-clockwise. In converting a solid atom into the liquid state, electrons left to the center of the atom orientate south to east anti-clockwise, and electrons right to the center of the atom orientate south to west clockwise. These fundamental revolutions shed new light on the development of science and engineering of materials.
Quantitative response relationships between annual precipitation in China from 1951 to 2018 and its influencing factors
Authors: Lu Chang , Ma Long , Liu Tingxi , Huang Xing , Sun Guohua 
Published: April 2022

Abstract
Continuous changes in the global climate have exacerbated the uneven spatial distribution of water resources. The quantitative response relationships between precipitation and its influencing factors are an important research topic. In this study, the responses of precipitation to its influencing factors were quantified by analysing the large-spatial-scale data such as the monthly precipitation data of 619 meteorological stations in China from 1951 to 2018, the CMIP6 data, and the AMO through empirical orthogonal function decomposition, partial redundancy analysis, and ensemble empirical mode decomposition. As shown by the results, the overall response relationships between precipitation in China and the AMO and MEI were relatively strong, and the PDO and AGG affected precipitation in western China. The precipitation in the area north of 25 °N had strong response relationships with the SR and AO. AP affected the precipitation in Northeast China, while WS affected the precipitation in North China and western China. RH affected the precipitation in the regions south of 25 °N. The response relationship between precipitation and CO2 was weakest. The total contribution rate of the influencing factors to the annual precipitation was higher in the west and lower in the east. In the regions west of 100 °E, the total contribution rate of the influencing factors to annual precipitation increased from south to north. In the regions east of 100 °E, the total contribution rate of the influencing factors to the annual precipitation decreased from north and south to the central area, AO and AP contributed little to the annual precipitation across China.
OS MÚLTIPLOS ENFOQUES DA INTERDISCIPLINARIDADE NO AMBIENTE ACADÊMICO
Authors: Balbino José , De Fátima Nunes Silva Helena , Pena de Couto Mariele 
Published: April 2022

O estudo analisa os diferentes enfoques empregados ao termo “interdisciplinaridade” nas pesquisas cientificas. O estudo não tem a pretensão de estabelecer um conceito consolidado sobre a interdisciplinaridade, mas de propor reflexões e contribuir para o avanço do entendimento sobre o tema. Contextualiza a interdisciplinaridade nas pesquisas brasileiras e realiza análise de conteúdo em 46 artigos publicados a partir de 2016. A análise de conteúdo resulta na identificação de nove categorias sobre a utilização do conceito de interdisciplinaridade e suas características a partir dos autores que apresentam estudos sobre este tema. Foram identificadas oito categorias, onde a interdisciplinaridade pode ser compreendida como: uma alternativa à produção do conhecimento; uma possibilidade de análise holística; além da combinação de saberes e disciplinas; a interação entre diversos campos do conhecimento; proposta de novos conhecimentos; a partir das relações das disciplinas; uma forma de superação dos limites disciplinares; perspectiva do sujeito ou do objeto de pesquisa; e, perspectiva do objeto de pesquisa. A análise das categorias revela a amplitude conceitual e a prática da interdisciplinaridade enquanto elemento propulsor do desenvolvimento de estudos acadêmicos e pesquisas.
ESTÁGIO DOCÊNCIA, QUALIFICAÇÃO PROFISSIONAL E REFLEXIVIDADE CRÍTICA
Authors: Guedes Neves Fagner Henrique 
Published: April 2022

Este artigo veicula a análise de uma experiência de estágio supervisionado docente vivenciada num curso de licenciatura em Sociologia na Região Metropolitana do Rio de Janeiro. Mediante uma metodologia de pesquisa que possibilitou planejar, executar e avaliar práticas pedagógicas em quatro disciplinas de Pesquisa e Prática de Ensino, o processo buscou empreender ciclos de reflexões, ações e novas reflexões favoráveis ao aprimoramento pessoal-profissional docente. Na dialética entre o vivido e o projetado, a iniciativa mostrou que o estágio tem potencialidade de ser um campo propício ao desenvolvimento de uma práxis favorável a uma qualificação profissional de qualidade. O estágio pode representar um divisor de águas na construção de identidades docentes comprometidas com uma educação básica democrática em todas as suas disciplinas.
This article analyzes a teaching internship experience lived in a degree course in Sociology in the Greater Rio area. Through a research methodology on planning, executing and evaluating pedagogical practices in four disciplines of Research and Teaching Practice, the process aims to develop cycles of reflections, actions and new reflections favorable to the personal-professional improvement of teachers. In a dialectical relationship between the lived and the projected, the initiative showed that the internship has the potential to be a favorable field for the development of a praxis favorable to a quality professional qualification. The internship can represent a breakpoint in the construction of teaching identities concerned to a democratic education in all its subjects.
Design and Screening of KLHL22 Inhibitors by Homology Modeling,
Molecular Docking, and Molecular Dynamics Simulation
Authors: Kang Congmin , Gao Chenglong , Sun Chuance , Zhang Lichuan , Zhang Haoran , Yu Rilei 
Published: April 2022

Background:
Kelch-like protein 22 (KLHL22) was a newly discovered proto-oncogene and it
is highly expressed in multiple breast cancer cell lines. Inhibition of KLHL22 can induce autophagy in
tumor cells by regulating the mTORC1 pathway.

Methods:
In this study, the structure of the KLHL22 protein was predicted by homology modelling. The
model was evaluated by Ramachandran Plot and Profile-3D. Virtual screening of a drug-like small molecule
library of 400,000 compounds was performed, and six potentially active compounds were obtained.

Results:
Among them, compound 1 had the best docking posture with docking energy of -8.42 kcal/mol.
Therefore, we further modified the structure of compound 1. 12 unreported compounds with lower docking
energies were obtained. The results of ADMET prediction performed on them showed good druggability.
The 60 ns molecular dynamics simulations were performed for compounds 1 and 10. MD studies
showed that the complexes had stable RMSD, and the compounds formed good H-bonds interactions with
essential amino acids (ASP64, TRP192).

Conclusion:
These results may provide new insights into the design and development of potent novel
KLHL22 inhibitors.
In silico Studies on Potential Inhibitors of the Penicillin Binding Protein 2B
(PBP2B) of the Resistant G54 and Intermediate-resistant Hungary 19A-6
and SP195 Strains of Streptococcus Pneumoniae
Authors: Suvaithenamudhan Suvaiyarasan , Parthasarathy Subbiah 
Published: April 2022

Background:
Mutations in Penicillin Binding Protein 2B (PBP2B) lead to resistance against
commercial β-lactam antibiotics among some strains of Streptococcus pneumoniae. In this study, the
molecular mechanism of resistance and the alternate strategy for controlling the Penicillin Binding Protein
2B (PBP2B) of resistant G54 and the two intermediate-resistant Hungary19A-6 and SP195 strains of
Streptococcus pneumoniae are determined using an in silico approach.

Methods:
In this study, we considered four ligand compounds, namely ZINC59376795, ZINC36922620,
ZINC39550705, and ZINC36953975 of the ZINC database, identified through high-throughput screening
(HTS) study for the resistant strain (5204-PBP2B). Glide XP docking and molecular dynamic simulation
studies were performed on the PBP2B of the three resistant strains chosen for this study. The stability
analysis was performed with prime-MM/GBSA, and the binding free energy, RMSD, and RMSF were
also evaluated.

Results:
Out of the four ligands, the ZINC39550705 ligand was found to form a stable complex with
PBP2B of all three strains. Furthermore, this ZINC39550705 ligand was observed to form four hydrogen
bonds with the PBP2B of all three strains. Molecular dynamics simulations were performed with these
four selected ligands and targets. The resulting binding pattern, RMSD, RMSF, and hydrogen bond calculation
analyses provide deeper insight into the molecular interactions of these four selected ligands with
the PBP2B of the three resistance strains of S. pneumoniae.

Conclusion:
The interaction of the selected ligand molecules and PBP2B of the resistant strains of S.
pneumoniae revealed that hydroxyl amino acid Thr at position 224, acidic amino acids including Glu at
positions 301, 245, and 240, amidic amino acids, Asn at positions 265 and 260, and aliphatic amino acid
Gly at the 302 position had a crucial role in the formation of hydrogen bonds with most of the selected
ligands that contributed to the stability of the complexes. The molecular dynamics simulation further
confirmed that the stability of ligand ZINC39550705–PBP2B of all mutant strains was higher compared
to other ligand-protein complexes evaluated in the present study. Selected ligand molecules showed significant
properties of the inhibitor to be used against the resistant strains of S. pneumoniae, and the ligand
ZINC39550705, in particular, is a potential alternative to commercial β-lactam antibiotics.
Infection and Severity of COVID-19 Infection Among Healthcare Workers:
A Report from Egypt
Authors: Moustafa Ehab F , Hassany Sahar M , Soliman Asmaa Mohamed Ahmed , Ezz-Eldin Mohammed , Zaghloul Nariman , Abd-Elsalam Sherief 
Published: April 2022

Backgrounds & Aim:
Coronavirus disease 2019 (COVID-19) is a severe acute respiratory
syndrome caused by Coronavirus. Knowledge of the fate of infection and risk factors among health
care workers is essential to enforce special infection control measures. We aimed to determine the
percentage of COVID-19 infection and the associated risk factors as well as the predictors of COVID-
19 among health care workers in Assiut University Hospital.

Methods::
A cross-sectional study was performed that included one hundred health care workers that
were confirmed by PCR to be COVID-19 cases admitted to Assiut University Hospital over six months
between May 2020 and November 2020. All participants were subjected to thorough history taking and
full clinical examination as well as investigations.

Results:
Out of the 100 HCWs enrolled in the study, 52% were males, 26% were obese, 68% were
doctors, and 38% were from the medical department. Fourteen percent of healthcare workers were
admitted to ICU, of which 93% were cured. The predictors for severity of cases were as follows: being
a doctor OR (6.804) P=0.037, old age OR (1.179) P=0.000, and hospital stay OR (0.838) P=0.015.

Conclusion:
Health care workers are at risk for severe COVID-19 infection. Being a doctor, old age,
and duration of hospitalization were the predictors for the severity of cases of health care workers.
Facial Esthetic Analysis of Nepalese Subjects
Authors: Shah Pravin K. , Shrestha Situ , Rokaya Dinesh 
Published: April 2022

Background:
Facial beauty is a prime concern in facial esthetic treatments and facial plastic surgery. The cephalometric can be used in the diagnosis, treatment planning, assessing the growth pattern in the craniofacial complex and skeletal disproportion with the relationships of the teeth to their supporting bone.

Objective:
The objective of this research was to analyze the face, evaluate the variability between males and females, and determine the cephalometric norms of Nepalese subjects based on Ricketts analysis.

Materials and Methods:
Craniofacial analysis of 106 Nepalese Brahmins subjects (60 females and 46 males) was done using the lateral cephalogram. The samples were criteria selected who met the criteria; well-balanced face, class I canine relation, and class I molar relation with normal occlusion. Ten parameters of Ricketts analysis were measured and analyzed using SPSS 20. The results were compared among males and females using Independent T-test with P value = 0.05.

Results:
The mean values of the facial axis, mandibular plane angle, mandibular arc, convexity at A were higher among the Brahmin females compared to Brahmin males. While the mean values of lower facial height, lower incisor to A Pog distance, lower incisor to A Pog angle, upper molar to PTV, and distance from lower lip to E plane were higher among the Brahmin males compared to Brahmin females. Female had smaller craniofacial variables compared to males. The mean values of upper molar position are higher for both males and females compared to the standard value of 12 ±3 mm; however, the mean values are significantly higher among males compared to females (P = 0.001). It showed that the facial axis, chin position, lower facial height, and facial depth were no significant differences between Nepalese males and females.

Conclusion:
There was sexual dimorphism in craniofacial features in Nepalese Brahmins. Female had smaller craniofacial variables compared to males. This research provided an overview of craniofacial features and they can be a norm for Nepalese Brahmins in orthodontic diagnosis and treatment planning.
White Spot Lesions: A Serious but Often Ignored Complication of Orthodontic Treatment
Authors: Marya Anand , Venugopal Adith , Karobari Mohmed Isaqali , Rokaya Dinesh 
Published: April 2022

Objective:
The objective of this narrative review is to present an overview of the prevalence, clinical manifestation, diagnosis, and latest advances on white spot lesions.

Background:
White spot lesions have been defined as the earliest stage of demineralization on enamel surfaces that are easily discernible to the human eye.

Methods:
Relevant articles on white spot lesions were searched and reviewed from March 1975 till May 2021 in Pubmed, Scopus, Google Scholar, and ScienceDirect and were included in this review.

Results:
Even though the orthodontic field has seen several advances over the last few years, this is one complication that persists. White spot lesions are very commonly seen after completion of fixed orthodontic therapy when brackets are debonded. Previously conducted research has shown that there is a high prevalence rate of white spot lesions, which ranges from 50 to 90%. On intra-oral examination, a white spot can be seen as a matte-textured, opaque white lesion. Since the demineralization process takes place below the enamel surface, the outer layer only demonstrates pores that affect the natural light refractory properties of a tooth. This is what leads to the characteristic appearance of these lesions. One of the goals of modern dentistry is to treat non-cavitated lesions by promoting remineralization without the involvement of any invasive procedures.

Conclusion:
Fixed orthodontic therapy is usually a lengthy process and requires active cooperation between the orthodontist and the patient. However, it is the responsibility of the treating orthodontist to examine the tooth surfaces at each appointment to diagnose a developing white spot lesion as early as possible. With recent advances in diagnostic techniques, it has become much easier to identify these initial lesions and prevent their progression to cavitated lesions.