bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoxic breathing produces more intense hypoxemia in elderly women than in elderly men
Authors: Zhao Jinfeng , Ding Yanfeng , Kline Geoffrey P. , Zhou Zhengyang , Mallet Robert T. , Shi Xiangrong 
Published: October 2022

Background: Brief hypoxic exposures are increasingly applied as interventions for aging-related conditions. To optimize the therapeutic impact of hypoxia, knowledge of the sex-related differences in physiological responses to hypoxia is essential. This study compared hypoxia-induced hypoxemic responses in elderly men and women.Methods: Seven elderly men (70.3 ± 6.0 years old) and nine women (69.4 ± 5.5 years old) breathed 10% O2 for 5 min while arterial (SaO2; transcutaneous photoplethysmography) and cerebral tissue O2 saturation (ScO2; near-infrared spectroscopy), ventilatory frequency, tidal volume, minute-ventilation, and partial pressures of end-tidal O2 (PETO2) and CO2 (mass spectrometry) were continuously monitored. Cerebral tissue oxygen extraction fraction (OEF) equaled (SaO2–ScO2)/SaO2.Results: During 5 min hypoxia SaO2 fell from 97.0 ± 0.8% to 80.6 ± 4.6% in the men and from 96.3 ± 1.4% to 72.6 ± 4.0% in the women. The slope ΔSaO2/min was steeper in the women than the men (−4.71 ± 0.96 vs. −3.24 ± 0.76%/min; p = 0.005). Although SaO2 fell twice as sharply per unit decrease in PETO2 in the women than the men (−1.13 ± 0.11 vs. −0.54 ± 0.06%/mmHg; p = 0.003), minute-ventilation per unit hypoxemia increased less appreciably in the women (−0.092 ± 0.014 vs. −0.160 ± 0.021 L/min/%; p = 0.023). OEF fell with hypoxia duration in the women, but remained stable in the men.Conclusion: During 5 min hypoxic breathing, elderly women experience more intense hypoxemia and reduced chemoreflex sensitivity vs. their male counterparts, which may lower OEF stability in women despite augmented O2 dissociation from hemoglobin during hypoxia. These sex-related differences merit attention when implementing brief hypoxic exposures for therapeutic purposes.
The effects of cognitive behavioral therapy in women with polycystic ovary syndrome: A meta-analysis
Authors: Tang Rong , Yang Junlan , Yu Yanmei , Fang Yuying 
Published: October 2022

BackgroundCognitive behavioral therapy (CBT) has well-characterized benefits in alleviating diseases associated with depression, anxiety, and obesity, resulting in a marked improvement in the patient’s quality of life. There are some studies regarding the effects of CBT on patients with polycystic ovary syndrome (PCOS). However, there is still no report of a meta-analysis for systematic assessment.ObjectivesThis study aimed to evaluate the effectiveness of CBT in improving weight loss, anxiety, depression, life quality, compliance, and pregnancy outcomes in patients with PCOS.MethodsStudies regarding CBT related to PCOS in PubMed, Cochrane library, Embase, ClinicalTrials.gov, CNKI, and WANFANG DATA were searched for up to 19 November 2020. A random-effects model was used to perform a meta-analysis.ResultsEight trials regarding CBT compared with lifestyle modification and routine treatments were included. No differences in depression (SMD –1.11; 95% CI –2.28, 0.07; P &gt; 0.05), body mass index (BMI) (SMD 0.88; 95% CI –0.94, 2.71; P &gt; 0.05), or overall life quality (SMD 1.24; 95% CI –0.44, 2.92; P &gt; 0.05) were evident between CBT and control groups; however, anxiety (SMD –1.12; 95% CI –2.1, –0.13; P &lt; 0.05) and quality of life in hirsutism (SMD 0.92; 95% CI 0.48, 1.35; P &lt; 0.05) were significantly improved. For secondary outcomes, both patient compliance and pregnancy rate were improved, but no significant change in pregnancy loss rate was identified.ConclusionCBT exhibited obvious advantages in the alleviation of anxiety, improvement of quality of life in hirsutism, and increase of compliance and pregnancy rate in patients with PCOS. Larger and higher-quality randomized controlled trials are needed to clarify the role of CBT in PCOS.Systematic review registration[https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD42021225856].
Effects of risperidone on psychotic symptoms and cognitive functions in 22q11.2 deletion syndrome: Results from a clinical trial
Authors: Latrèche Caren , Maeder Johanna , Mancini Valentina , Schneider Maude , Eliez Stephan 
Published: October 2022

BackgroundCarriers of the 22q11.2 deletion syndrome (22q11DS) have an enhanced risk of developing psychotic disorders. Full-blown psychosis is typically diagnosed by late adolescence/adulthood. However, cognitive decline is already apparent as early as childhood. Recent findings in mice show that antipsychotic medication administered during adolescence has a long-lasting neuroprotective effect. These findings offer promising evidence for implementing preventive treatment in humans at risk for psychosis.MethodsWe conducted a 12-week double-blind randomized controlled clinical trial with individuals with 22q11DS. Recruitment difficulties resulted in a final sample size of 13 participants (n = 6 treated with antipsychotics and n = 7 receiving placebo). We examined the response to treatment and assessed its short- and long-term effects on psychotic symptomatology using the Structured Interview for Psychosis-Risk Syndromes (SIPS) and cognitive measures.ResultsFirst, two treated participants discontinued treatment after experiencing adverse events. Second, treated participants showed a short-term improvement in 33.3% of the SIPS items, mainly those targeting negative symptoms. Third, reliable improvements in at least one measure of working memory and attention were respectively found in 83.3 and 66.7% of treated participants.ConclusionThis is the first double-blind study to investigate the potential neuroprotective effect of antipsychotics in humans at risk for psychosis. Our preliminary results suggest that antipsychotic treatment may prevent long-term deterioration in clinical symptoms and cognitive skills. Yet, given the limited sample size, our findings need to be replicated in larger samples. To do so, future studies may rather adopt open-label or retrospective designs to ensure sufficient power.Clinical trial registration[www.ClinicalTrials.gov], identifier [NCT04639960].
A preoperative scoring system to predict the probability of laparoendoscopic single-site extracorporeal cystectomy in patients with benign ovarian cysts
Authors: Tan Wenwei , Deng Yuan , Deng Li , Tang Shuai , Yao Yuanyang , Wei Huanyu , Zhong Kuiyan , Wang Yanzhou 
Published: October 2022

ObjectiveTo develop a preoperative scoring system (PSS) to predict whether laparoendoscopic single-site extracorporeal (LESS-E) cystectomy can be performed in patients with benign ovarian cysts.MethodWe reviewed data on patients who underwent LESS cystectomy between August 2016 and October 2019 at the first Affiliated Hospital, Army Medical University. The independent predictors of LESS-E cystectomy in patients with benign ovarian cysts were identified using multivariate logistic regression analyses. A nomogram for predicting LESS-E cystectomy in patients with benign ovarian cysts was developed, and to simplify the score, we establish a preoperative scoring system to guide the choice of surgical approach in patients with highly probable benign ovarian cysts.ResultsOur analysis showed that age, BMI, height and the diameter of ovarian cysts were independent predictors of LESS-E cystectomy. A nomogram was developed based on these four factors, which had a concordance index of 0.838 and R2 = 0.415. To simplify the score, the predicted indicators in the regression model were scored by dividing the beta coefficient by the absolute value of the minimum beta coefficient, and the sum of each predictor score established a PSS. In the total set, the selected cutoff value according to the maximum point of the Youden index was 8, and a preoperative score ≥ 8 identified patients undergoing LESS-E cystectomy with a positive predictive value of 67.4% and a negative predictive value of 88.6%.ConclusionA PSS to predict the chances of LESS-E cystectomy was established. This system could be helpful for selecting the appropriate surgical strategy for patients with benign ovarian cysts.
Molecular Characterization of bHLH Transcription Factor Family in Rose (Rosa chinensis Jacq.) under Botrytis cinerea Infection
Authors: Ullah Ikram , Yuan Wenbin , Uzair Muhammad , Li Sisi , Rehman Obaid Ur , Nanda Satyabrata , Wu Hongzhi 
Published: October 2022

Rose (Rosa chinensis Jacq.) is an important economic ornamental crop and its yield is affected by different biotic and abiotic stresses. Among the biotic stresses, the gray mold disease caused by Botrytis cinerea is a serious threat to rose production. The basic helix-loop-helix (bHLH) is a large transcription factor family involved in several vital plant physiological processes, including growth, development, and stress response. However, no substantial reports exist on bHLH genes in rose. Here, the genome-wide identification, characterization, and expression analysis of the rose bHLH (RcbHLH) genes was carried out. In total, 100 RcbHLHs were identified in the rose genome and mapped onto different rose chromosomes. The gene duplication analysis revealed both tandem and segmental duplications in RcbHLHs. The RcbHLHs among other plant bHLHs were divided into 21 sub-groups on the phylogenetic tree. Additionally, prediction of the different cis-regulatory elements and the gene ontology of the identified RcbHLHs indicated their possible functions in rose plants. The expression analysis of selected RcbHLHs genes in two contrasting rose varieties (A29 = Black Baccara and XS = Sweet Avalanche) under B. cinerea infection provided insights into the involvement of RcbHLHs in rose–B. cinerea interactions. Moreover, this study provided details on the bHLH family genes in rose and their potential roles in rose defense against B. cinerea infection.
Comparison of Tacrolimus Intra-Patient Variability during 6–12 Months after Kidney Transplantation between CYP3A5 Expressers and Nonexpressers
Authors: Nuchjumroon Almas , Vadcharavivad Somratai , Singhan Wanchana , Poosoonthornsri Manorom , Chancharoenthana Wiwat , Udomkarnjananun Suwasin , Townamchai Natavudh , Avihingsanon Yingyos , Praditpornsilpa Kearkiat , Eiam-Ong Somchai 
Published: October 2022

A high intra-patient variability (IPV) of tacrolimus exposure is associated with poor long-term kidney transplantation outcomes. To assess the influence of cytochrome P450 (CYP) 3A5 genetic polymorphisms on tacrolimus IPV, 188 clinically stable kidney transplant recipients, who had received an immediate-release tacrolimus-based immunosuppressive regimen, were enrolled in this retrospective cohort study. Genotyping of CYP3A5*3 (rs776746) was performed and 110 (58.5%) were identified as CYP3A5 expressers and 78 (41.5%) as nonexpressers. Whole blood tacrolimus concentrations were analyzed by chemiluminescent microparticle immunoassay. Dose-adjusted trough tacrolimus concentrations (C0/D) measured at months 6, 9, and 12 were used to determine IPV. There were no significant differences in the IPV estimated by the coefficient of variation, the IPV calculated by mean absolute deviation method, and the proportions of recipients with the IPV estimated by the coefficient of variation of 30% or more between CYP3A5 expressers and nonexpressers (p = 0.613, 0.686, and 0.954, respectively). Tacrolimus C0/D in CYP3A5 expressers was approximately half of those in nonexpressers, overall (p < 0.001). In both CYP3A5 expressers and nonexpressers, tacrolimus C0/D increased gradually from month 6 to month 12 (p = 0.021). There was no evidence that the CYP3A5 polymorphisms significantly influence tacrolimus IPV during the 6 to 12 months after kidney transplantation.
Isolation and Production of Human Monoclonal Antibody Proteins against a Toxocara canis Excretory–Secretory Recombinant Antigen
Authors: Baharudeen Zamrina , Noordin Rahmah , Soon Lim Theam , Balachandra Dinesh , Anuar Nor Suhada , Mustafa Fatin Hamimi , Rahumatullah Anizah 
Published: October 2022

Toxocariasis is a widespread zoonotic parasitic disease with a significant socioeconomic impact, particularly on underprivileged communities. Limitations of existing diagnostic tools and vague presenting symptoms may lead to misdiagnosis, thus underestimating the actual global impact of the disease. The present study describes the isolation and production of novel recombinant monoclonal antibodies against Toxocara canis recombinant TES-26 antigen (rTES-26) utilizing a human helminth scFv phage display library. The isolated antibody clones were characterized based on their gene sequences and binding characteristics. Three clones representing unique gene families (clone 48: IgHV3-LV1; clone 49: IgHV3-LV3; clone 50: IgHV6-LV3) were isolated, but only clones 48 and 49 showed successful insertion of the full-length scFv antibody sequence after sub-cloning. Both clones produced antibody proteins of good solubility and satisfactory yield and purity. Binding assays via Western blot and ELISA using rTES-26 and Toxocara canis native protein showed that both monoclonal antibodies were highly specific and sensitive to the target antigen. A preliminary antigen detection ELISA showed the diagnostic potential of the monoclonal antibody proteins. The proteins can also be useful in studying host–parasite interactions and therapeutic applications.
AVALIAÇÃO MICROBIOLÓGICA DA QUALIDADE SANITÁRIA DA PRAIA DA GRACIOSA NA CIDADE DE PALMAS - TO
Authors: Rodrigues Lorhane , Albarello Gellen Luis Fernando , Cintra Marcos Rodrigues , Pereira Ernane Gerre 
Published: October 2022

A constante preocupação relacionada a saúde pública, é temática de contínuos debates e pesquisas, a fim de prevenir doenças e infecções. A água de recreamento é uma fonte de contágio caso não esteja nos parâmetros ideais, trazendo risco à saúde humana. Diante desta afirmativa, o presente estudo objetiva avaliar a qualidade microbiológica da água da praia da Graciosa na cidade de Palmas – TO. Foram analisadas 21 amostras de água em sete pontos da praia, através da determinação de coliformes totais e termotolerantes pela técnica de tubos múltiplos e identificação da presença de E. coli, e contagem de Heterotróficos, sendo estes microrganismos utilizados como indicadores de contaminação fecal. Todas as amostras foram positivas para E. coli, 6 amostras indicaram contaminação por coliformes termotolerantes, e todas as amostras excederam o valor padrão de 500 UFC/mL de heterotróficos. Os resultados da análise de coliformes totais e fecais foram correlacionados com a Resolução CONAMA 274/2000, em que apesar de 28% das amostras apresentarem contaminação por coliformes termotolerantes, os valores obtidos não ultrapassaram o limite de 80% das amostras estarem contaminadas de acordo com a resolução, sendo assim a água da praia da Graciosa é determinada como própria para o banho. A contagem de heterotróficos foi relacionado com a RDC N° 91, de 30 de Junho de 2016, em que os resultados demonstraram insatisfatórios. Apesar dos coliformes não exceder o valor estabelecido, é importante ressaltar que a referida praia deve estar em constante monitoramento em relação a sua qualidade sanitária, para não oferecer riscos à saúde humana.
FEATURES OF PSYCHOTHERAPEUTIC WORK WITH FAMILIES OF DRUG DEPENDENT PATIENTS
Authors: Sedykh K. , Lavrinenko V. 
Published: October 2022

The article characterizes the types of relationship configurations in chemically dependent families; the internal conflicts of the addict's personality are described; the role of shame in the addiction formation is highlighted. The theoretical principles of understanding the family relationships configurations essence and its specificities in families with drug addicts are presented.
It is presented that the most typical for families with drug addicts are symbiotic-conflict and conflict types of family relationships configurations, which allow the interaction participants to realize a dependent type of attachment. The phenomenon of family configurations repetition in different generations of the same family is revealed and described.
Some practical psychotherapeutic techniques in dealing with addicted patients are highlighted. In particular, the differences in the implementation of psychotherapy of families of drug addicts with a predominance of symbiotic-conflict (reduction of emotional dependence) or conflict (search for other ways of communication) types of configurations are shown.
The role of shame in working with drug addicts is described, constructive and non-constructive variants of the influence of shame on the process of overcoming excessive use are differentiated.
Based on the description of the prevailing types of intrapersonal conflicts in drug addicts, appropriate strategies for psychotherapeutic work with them are presented.
Kajian Potensi Penerapan Teknologi Smart Airport di Bandara Internasional Soekarno-Hatta Jakarta Indonesia
Authors: Hanantyo Burhanuddin , Susanto Tony Dwi 
Published: October 2022

Pandemi covid-19 di awal tahun 2020 sangat berdampak pada industri penerbangan terutama industri Bandar Udara. Munculnya konsep ‘New Normal’ atau kebiasaan baru berdampak pada penyesuaian pelayanan Bandara di Indonesia. Studi literatur yang dilakukan pada bandara di negara-negara maju seperti Jerman, Amerika Serikat, Finlandia dan Jepang yang telah menerapkan beberapa Smart Airport Technologies seperti Robot Parkir, Indoor Navigation, Automatic Desk Check In, Facial Recognition, Robot Humanoid dan terbukti mampu meningkatkan kepuasan pengguna jasa bandara. Tujuan dari penelitian adalah mengeksplorasi peluang potensial penerapan Smart Airport Technologies di Bandara Internasional Soekarno-Hatta Jakarta Indonesia dengan melakukan beberapa analisis kondisi eksisting dan benchmarking terhadap bandara di negera-negara maju yang telah sukses menerapkan Smart Airport Technologies. Dalam mencapai tujuan penelitian ini, digunakan metode studi literatur. Studi literatur yang digunakan dalam jurnal ini berasal dari berbagai berbagai jurnal internasional yang membahas mengenai Smart Airport Technologies yang terbukti mampu meningkatkan kepuasan pengguna jasa bandara. Hasil penelitian ini yakni kontribusi praktis berupa Pemunculan Solusi Smart Airport Technologies serta dapat menjadi rekomendasi kepada Bandara Internasional Soekarno-Hatta Jakarta Indonesia dalam menerapkan Smart Airport Technologies kedepan. Dalam hal kontribusi kelimuan yang dapat dihasilkan pada penelitian ini yakni sebagai Guideline Blueprint industri bandara udara di Indonesia dalam menerapkan Smart Airport Technologies. Penelitian ini memiliki keterbatasan di mana objek penelitian yang digunakan hanya Bandara Soekarno Hatta, pada penelitian selanjutnya objek penelitiaan dapat diperluas di bandara-bandara lain di Indonesia yang ingin menerapkan Smart Airport Technologies.
Avanços e desafios na saúde das populações ribeirinhas na região amazônica: uma revisão integrativa
Authors: Santos Isabella Oliveira , Rabello Ricardo Elias Duarte , Corrêa Rachel Geber , Melo Giane Zupellari dos Santos , Monteiro Ângela Xavier 
Published: October 2022

O objetivo deste estudo foi evidenciar, em publicações nacionais e internacionais, os avanços e desafios na saúde de populações ribeirinhas que vivem na Amazônia Legal brasileira. Foi realizada uma revisão integrativa entre os dias 1º e 30 de maio de 2021, na qual foram selecionados artigos publicados entre 2014 e 2021, indexados nas bases eletrônicas da BVS e SciELO. A estratégia de busca retornou 52 artigos, no entanto somente 10 foram incluídos. Destaca-se um predomínio de artigos que abordam os desafios a serem superados no atendimento às populações ribeirinhas, sendo observado um destaque para a falta de preparo das equipes de saúde e para a necessidade de ampliação dos serviços que considerem as diferenças culturais e as determinantes sociais que atingem essas populações. Observa-se que, apesar da ocorrência de alguns avanços no atendimento em saúde às populações ribeirinhas da Amazônia, a maioria dos estudos descreve que desafios são comuns e frequentes e que mudanças para que as necessidades dessa população sejam alcançadas acontecem de forma lenta, não atendendo às expectativas atuais dessas comunidades.
Educação Interprofissional e Prática Colaborativa: percepções de preceptores do internato médico em uma capital da Amazônia brasileira
Authors: Gonzaga Branco Junior Arlindo , Moreira Katia Fernanda Alves , Fernandes Daiana Evangelista Rodrigues , Farias Edson dos Santos , Moura Cleson Oliveira de 
Published: October 2022

Educação Interprofissional e Prática Interprofissional Colaborativa são temas emergentes, constituindo-se em componentes fundamentais de formação profissional e de atenção à saúde. Este trabalho teve tem como objetivo analisar as características de prontidão para o trabalho interprofissional bem como o uso da prática colaborativa dos preceptores do internato médico de Porto Velho, Rondônia. Trata-se de um estudo transversal, realizado a partir do questionário The Readiness for Interprofessional Learning Scale, traduzido e validado para o Brasil em 2015, aplicado a 30 profissionais de saúde, entre médicos e enfermeiros, preceptores do internato médico em Atenção Primária à Saúde. Entre os resultados, observou-se que, no domínio “identidade profissional” – que se refere à autonomia profissional e aos objetivos clínicos de cada profissão –, os profissionais avaliados estão nas zonas de alerta e de perigo, sendo as médias apuradas de 3,7483±0,96896 para médicos e de 3,5873±1,09561 para enfermeiros. Faz-se necessário, então, investir na qualificação de profissionais voltada aos temas “trabalho em equipe” e “trabalho colaborativo”, com ênfase no domínio “identidade profissional”.
Analisis Jaringan Perpipaan Air Bersih Kecamatan Kota Atambua Kabupaten Belu
Authors: Bunganaen Wilhelmus , Moruk Maria Yunita , Udiana I Made 
Published: October 2022

Abstrak
Penelitian ini bertujuan untuk mengetahui besar kebutuhan air dan sistem jaringan perpipaan Kecamatan Kota Atambua untuk 20 tahun mendatang. Tahapan analisis yang dilakukan yaitu memproyeksi jumlah penduduk, memproyeksi fasilitas, menghitung kebutuhan air, membandingkan kebutuhan air dan ketersediaannya untuk menentukan pembagian pemenuhan kebutuhan air serta melakukan simulasi jaringan menggunakan Software Epanet 2.0. Hasil analisis kebutuhan air harian maksimum untuk tiap kelurahan adalah sebagai berikut untuk Kelurahan Tenukiik sebesar 8,496 liter/detik, untuk Kelurahan Fatubenao sebesar 15,947 liter/detik, untuk Kelurahan Manumutin sebesar 23,802 liter/detik dan untuk Kelurahan Kota Atambua sebesar 6,932 liter/detik. Hasil analisis Software Epanet 2.0 menunjukan bahwa semua memenuhi syarat (run was succsessful) namun masih terdapat beberapa parameter hidrolis pada node dan link yang nilainya belum memenuhi syarat kriteria perencanaan pipa. Nilai kehilangan energi untuk jaringan Kelurahan Tenukiik dan Fatubenao pada simulasi 1 sebesar 29,59 m/km, untuk jaringan kelurahan Manumutin pada simulasi 1 sebesar 46,29 m/km, dan untuk jaringan Kelurahan Kota Atambua sebesar 17,72 m/km.