bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic value of a medical algorithm for investigation of perioperative hypersensitivity reactions
Authors: Sverrild Asger , Carruthers John , Murthee Kavitha Garuna , Moore Alice , O'Hehir Robyn Elizabeth , Puy Robert , Hew Mark , Zubrinich Celia 
Published: September 2022

AbstractBackgroundEvaluation of perioperative hypersensitivity (POH) is challenging, and accurate screening tools are needed to optimize the diagnostic process. We aimed to assess and validate the diagnostic value of a published algorithm (using tryptase and clinical presentation) to identify appropriate individuals for further testing for IgE‐mediated POH.MethodsWe analysed the clinical presentation (tryptase elevation, cardiovascular, respiratory, skin involvement) of patients proceeding to testing for possible IgE‐mediated POH at a single tertiary referral centre, relative to subsequent skin testing and specific IgE results. Clinical presentations by drug class were also determined.ResultsIn 293 consecutive patients, the use of a published algorithm based on one or more of; (i) defined increase in serum tryptase, (ii) involvement of at least two‐organ systems, or (iii) presentation with new urticaria and/or angioedema; was highly sensitive [98.8% (CI95: 95.7–99.9%)] but less specific [34.6% (CI95: 25.7–44.4%)] in identifying patients testing positive on skin testing and/or specific IgE. Presentation with cardiovascular symptoms was also sensitive [89.8%(CI95: 84.2–94.0%)], while the combination of respiratory symptoms and increased tryptase was most specific [85.9%(CI95:76.6–92.5%)]. Respiratory involvement was more common in neuromuscular blocking agent allergy, while urticaria/angioedema was more common in antibiotic allergy.ConclusionThe published algorithm (of tryptase rise, two‐organ involvement or new urticaria/angioedema) is highly sensitive, and appropriate as a screening tool to identify patients suitable for testing for IgE‐mediated POH.
Hemisphere opposite to central retinal vascular trunk deviation is earlier affected by glaucomatous damage in primary angle‐closure glaucoma
Authors: Oh Richul , Lee Kyoung Min , Kim Martha , Oh Sohee , Kim Seok Hwan 
Published: September 2022

AbstractPurposeThe purpose of the study was to investigate whether the position of the central retinal vascular trunk (CRVT), as a surrogate for lamina cribrosa (LC) offset, is associated with the dominant hemisphere of visual field defect in primary angle‐closure glaucoma (PACG) eyes.MethodsCentral retinal vascular trunk deviation was measured from Bruch's membrane opening (BMO) centre, which was delineated by OCT imaging, using the horizontal midline as a reference. The dominant hemisphere developing visual field defect was defined as three connected abnormal points (having a p‐value < 5% probability of being normal) appearing in only one hemisphere or each point of the hemisphere having a statistically worse value compared with its mirrored point in the opposite hemisphere on pattern deviation plots.ResultsOne hundred five (80%) of 132 eyes with PACG had dominant hemisphere of visual field defect initially: 70 eyes (67%) in the superior and 35 eyes (33%) in the inferior hemisphere. The CRVT was located superiorly in the dominant superior visual field defect group (p < 0.001). A logistic regression analysis revealed that superior deviation of the CRVT was the only factor associated with dominant superior visual field defect (p < 0.001). Externally oblique border (EOB) presence was associated with larger BMO (p = 0.005) and angular deviation of CRVT (p = 0.002).ConclusionsCentral retinal vascular trunk deviation was associated with the dominant hemisphere of visual field defect in PACG eyes. This finding implies that the LC position relative to the BMO centre (LC/BMO offset) may incur structural vulnerability in the optic nerve head of PACG eyes.
Calcium‐channel blockers: Clinical outcome associations with reported pharmacogenetics variants in 32 000 patients
Authors: Türkmen Deniz , Masoli Jane A. H. , Delgado João , Kuo Chia‐Ling , Bowden Jack , Melzer David , Pilling Luke C. 
Published: September 2022

AimsPharmacogenetic variants impact dihydropyridine calcium‐channel blockers (dCCBs; e.g., amlodipine) treatment efficacy, yet evidence on clinical outcomes in routine primary care is limited. Reported associations in pharmacogenomics knowledge base PharmGKB have weak supporting evidence. We aimed to estimate associations between reported pharmacogenetic variants and incident adverse events in a community‐based cohort prescribed dCCB.MethodsWe analysed up to 32 360 UK Biobank participants prescribed dCCB in primary care (from UK general practices, 1990–2017). We investigated 23 genetic variants. Outcomes were incident diagnosis of coronary heart disease, heart failure (HF), chronic kidney disease, oedema and switching antihypertensive medication.ResultsParticipants were aged 40–79 years at first dCCB prescription. Carriers of rs877087 T allele in RYR3 had increased risk of hazard ratio (HF 1.13: 95% confidence interval 1.02 to 1.25, P = .02). Although nonsignificant after multiple testing correction, the association is consistent with prior evidence. We estimated that if rs877087 T allele could experience the same treatment effect as noncarriers, the incidence of HF in patients prescribed dCCB would reduce by 9.2% (95% confidence interval 3.1 to 15.4). In patients with a history of heart disease prior to dCCB (n = 2296), rs877087 homozygotes had increased risk of new coronary heart disease or HF compared to CC variant. rs10898815 in NUMA1 and rs776746 in CYP3A5 increased likelihood of switching to an alternative antihypertensive. The remaining variants were not strongly or consistently associated with studied outcomes.ConclusionPatients with common genetic variants in NUMA1, CYP3A5 and RYR3 had increased adverse clinical outcomes. Work is needed to establish whether outcomes of dCCB prescribing could be improved by prior knowledge of pharmacogenetics variants supported by clinical evidence of association with adverse events.
Dental implant proximity to adjacent teeth: A retrospective study
Authors: Han Hee‐seung , Kim Pil‐Jong , Kim Ki‐Tae , Kim Sungtae , Ku Young , Cho Young‐Dan 
Published: September 2022

AbstractBackground and PurposeThe purpose of this study was to assess the occurrence and prognosis of dental implant proximity or direct contact with the adjacent tooth and to evaluate the symptoms and complications in both the implant and the adjacent tooth. We then elaborate on treatment modalities and discuss the prevention of this phenomenon.Materials and MethodsThis retrospective study was conducted based on the dental clinical and radiographic records of 43 patients with implant‐tooth proximity of <1.0 mm or direct implant‐tooth contact. Multivariate Bayesian logistic regression was performed to examine the influence of individual variables on correcting major clinical variables.ResultsIn the multivariate regression analysis, the rate of occurrence of tooth symptom decreased by about 95% with every increase of 1.0 mm distance between implant and tooth (odds ratio [OR] = 0.1, 95% confidence interval [CI]: 0.004–0.680, p = 0.024). In the case of implant‐tooth root proximity in the anterior area, the OR of peri‐implantitis occurrence was 30.4‐fold greater than in posterior sites (OR = 30.4, 95% CI: 1.189–785.914, p = 0.040).ConclusionImplant‐tooth root proximity or direct implant‐tooth contact is an iatrogenic factor that causes various complications, including devitalization of the adjacent tooth and peri‐implantitis. Proactive prevention with surgical stents and intra‐operative periapical radiographs is needed. If proximity or contact is found during surgery, repositioning of the fixture to the correct location is recommended in order to maintain peri‐implant health and prevent complications.
Dental implants in dentate primary and secondary Sjögren's syndrome patients: A multicenter prospective cohort study
Authors: Maarse Floor , Fennis Willem M. M. , Twisk Jos W. R. , Korfage Anke , Santing Hendrik J. , den Hartog Laurens , Muradin Marvick S. M. , Maningky Melvin S. , Raghoebar Gerry M. , Vissink Arjan , Brand Henk S. , Jager Derk Hendrik Jan 
Published: September 2022

AbstractObjectivesTo prospectively assess the clinical performance and patient‐reported outcomes of dental implants in dentate patients with primary and secondary Sjögren's syndrome (pSS and sSS, respectively) compared to patients without SS.Materials and MethodsThirty‐seven implants were placed in 17 patients with pSS/sSS and 26 implants in 17 non‐SS patients to replace missing (pre)molars. Clinical performance, marginal bone‐level changes, patient satisfaction, and oral health‐related quality of life (OHRQoL) were assessed at 1 (T1), 6 (T6), 12 (T12), and 18 (T18) months after placement of the superstructure. Marginal bone‐level changes were measured on standardized dental radiographs. Clinical parameters included implant and crown survival, plaque, bleeding and gingival indices, and probing depth. Patient satisfaction and OHRQoL were assessed with validated questionnaires.ResultsImplant survival at T18 was 100% in the patients with pSS/sSS and 96.2% in the non‐SS group. Mean marginal bone loss at T18 did not differ between patients with pSS/sSS and non‐SS patients, 1.10 ± 1.04 and 1.04 ± 0.75 mm, respectively (p = .87). Clinical performance was good with no differences between the groups for all outcome measures (p > .05). OHRQoL in patients with pSS/sSS had improved significantly after placement of implant supported crowns at all measuring moments compared to baseline (p < .05). Nevertheless, patient satisfaction and OHRQoL remained significantly higher for patients without SS at all measuring moments (p < .05).ConclusionDental implants can be successfully applied in dentate patients with pSS/sSS and have a positive effect on OHRQoL.
Rational engineering of adeno‐associated virus capsid enhances human hepatocyte tropism and reduces immunogenicity
Authors: Han Jiabao , Zhu Liyu , Zhang Jingwen , Guo Lu , Sun Xuehan , Huang Cheng , Xu Kai , Zhang Ying , Li Wei , Zhou Qi 
Published: September 2022

AbstractObjectivesGene therapy based on recombinant adeno‐associated viral (rAAV) vectors has been proved to be clinically effective for genetic diseases. However, there are still some limitations, including possible safety concerns for high dose delivery and a decreasing number of target patients caused by the high prevalence of pre‐existing neutralizing antibodies, hindering its application. Herein, we explored whether there was an engineering strategy that can obtain mutants with enhanced transduction efficiency coupled with reduced immunogenicity.MethodsWe described a new strategy for AAV capsids engineering by combining alterations of N‐linked glycosylation and the mutation of PLA2‐like motif. With this combined strategy, we generated novel variants derived from AAV8 and AAVS3.ResultsThe variants mediated higher transduction efficiency in human liver carcinoma cell lines and human primary hepatocytes as well as other human tissue cell lines. Importantly, all the variants screened out showed lower sensitivity to neutralizing antibody in vitro and in vivo. Moreover, the in vivo antibody profiles of variants were different from their parental AAV capsids.ConclusionsOur work proposed a new combined engineering strategy and engineered two liver‐tropic AAVs. We also obtained several AAV variants with a higher transduction efficiency and lower sensitivity of neutralizing antibodies. By expanding the gene delivery toolbox, these variants may further facilitate the success of AAV gene therapy.
Metastasis of a basosquamous carcinoma arising in a nevus sebaceus
Authors: Ye Qian , Shen Xiao , Wang Jie , Li Feng‐Zeng , Fang Sheng 
Published: September 2022

AbstractNevus sebaceus (NS) is a congenital hamartoma of skin structures including the epidermis, sweat sebaceous glands, and hair follicles. It is known that secondary tumors can occur in NS. However, secondary metastatic malignancies are rare. Basosquamous carcinoma (BSC) is an aggressive type of basal cell carcinoma (BCC) characterized by squamous differentiation. Herein, we report a case of metastatic BSC that developed in a 73‐year‐old male with NS. The clinical presentation of this patient was that of an ulcerative nodule developing in a longstanding plaque‐like lesion consistent with NS. Histopathological examination revealed characteristic features of BCC with some areas of squamous differentiation in addition to the structure of a typical NS. Immunohistochemical expression of Ber‐EP4, AE1/AE3, and epithelial membrane antigen helped to make the diagnosis of BSC.
An artificial neural network for the prediction of the risk of malignancy in category III Bethesda thyroid lesions
Authors: Saini Tarunpreet , Saikia Uma Nahar , Dey Pranab 
Published: September 2022

AbstractBackgroundThe diagnosis of cases of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) by fine needle aspiration cytology (FNAC) is challenging for both cytopathologists and clinicians. It is extremely difficult to predict the risk of malignancy based on cytological features alone.Aims and ObjectivesIn this study, we attempted to construct an artificial neural network (ANN) model to predict the risk of malignancy in FNAC cases of AUS/FLUS in thyroid lesions based on cytological features.Materials and MethodsWe included two groups of AUS/FLUS cases: (1) 29 cases of histopathologically proven malignancy, and (2) 32 cases that had either been histopathologically proven to be benign, or for which no progress of malignancy on follow‐up had been observed in the last 2 years. Cytological characteristics were analysed semi‐quantitatively by two independent observers (TS and PD). Based on these data, we tried to generate an artificial neural network (ANN) model to differentiate between malignant and benign cases. The performance of the ANN was assessed using the confusion matrix and receiving operator curve.ResultsThere were 29 malignant cases of AUS/FLUS (histopathologically proven) and 32 benign/follow‐up cases in this study. There were 41 cases in the training set, 9 cases in the validation set and 11 cases in the test set. In the test group, the ANN model successfully distinguished between all benign (5/5) and malignant cases (6/6). The area under the receiver operating curve was 1.ConclusionThe present ANN model is well structured and coherent to distinguish malignant from benign outcomes in AUS/FLUS cases on cytology smears with no error. This is an open‐ended ANN model, and additional parameters and more cases could be included to make the model more robust.
The borderland of multiple sclerosis and functional neurological disorder: A call for clinical research and vigilance
Authors: Aybek Selma , Chan Andrew 
Published: September 2022

AbstractBackground and purposeFunctional neurological disorders (FNDs) have attracted much attention from the neurological medical community over the last decades as new developments in neurosciences have reduced stigma around these by showing brain network dysfunctions. An overlap with other neurological conditions such as multiple sclerosis (MS) is well known by clinicians but there is a lack of clinical and fundamental research in this field to better define diagnosis and therapeutic decisions, as well as a lack of deep understanding of the underlying pathophysiology.AimWe aimed to provide a critical commentary on the state of knowledge about the borderland between FNDs and MS.MethodsWe based our commentary on a joint point of view between an FND specialist and an MS expert.ResultsA brief review of the previous literature and relevant new studies covering the overlap between FNDs and MS is presented, along with suggestions for future research directions.ConclusionThere are clear diagnostic criteria for both FNDs and MS and a strict application of these will help better diagnosis and prevent unnecessary treatment escalation in MS or absence of referral to multimodal therapy in FND. Better teaching of younger neurologists is needed as well as prospective research focusing on pathophysiology.
Mate choice in a promiscuous poison frog
Authors: Peignier Mélissa , Bégué Lauriane , Gieseke Alina , Petri Diana , Ringler Max , Ringler Eva 
Published: September 2022

AbstractIn many animal species, members of one sex, most often females, exhibit a strong preference for mating partners with particular traits or resources. However, when females sequentially mate with multiple partners, strategies underlying female choice are not very well understood. Particularly, little is known if under such sequential polyandry females mate truly randomly, or if they actively try to spread mating events across multiple partners. In the present study, we used the highly promiscuous poison frog Allobates femoralis to investigate whether promiscuity could result from a preference for novel mates. Furthermore, we examined the importance of call characteristics for mate choice. We conducted mate choice experiments in a laboratory setup, by presenting females with recent mating partners or novel males. We recorded call characteristics of both males and the time females spent close to each male. In our trials, females preferred previous mating partners over novel males and also males with shorter advertisement calls. Results from previous studies on A. femoralis suggest that females in our trials recognized previous partners based on individual call characteristics. While mating decisions in the wild and in the laboratory might differ, our study provides first evidence for female mate choice in a poison frog with sequential polyandry.
RNA sequencing reveals the transcriptome profile of the atopic prurigo nodularis with severe itching
Authors: Shao Yixin , Zhu Yiqi , Xiao Zijing , Shen Yanyun , Dai Beiying , Tang Hui , Wang Duoqin 
Published: September 2022

AbstractPrurigo nodularis (PN), characterized by inevitable chronicity and severe pruritus, is most frequently associated with atopy compared with other origins. However, the skin transcriptomic profiling of PN arising from atopic dermatitis (AD), so‐called atopic PN (APN), remains unclear. We sought to explore the cutaneous transcriptome of APN with severe pruritus and compare it with classic AD. RNA sequencing was performed on the lesional skin from 13 APN to 11 AD patients with severe pruritus (itch numerical rating scale score ≥ 7) and normal skin from 11 healthy subjects. Quantitative real‐time polymerase chain reaction and immunochemistry were used for validation. We detected 1085 and 1984 differentially expressed genes (DEGs) in lesional APN skin and lesional AD skin versus normal skin, respectively. In total, 142 itch/inflammation‐related DEGs were identified. Itch/inflammation‐related DEGs, such as IL‐6, IL‐10, IL‐13, oncostatin M, and IL‐4 receptor, had elevated gene transcript levels in both diseases. The itch/inflammation‐related DEGs that increased only in APN were mainly neuroactive molecules, while many inflammatory mediators such as T helper 22‐related genes were found to be increased only in AD. Both disorders showed mixed Th1/Th2/Th17 polarisation and impaired skin barrier. In contrast to AD, M1/M2 macrophage activation, tumor necrosis factor production, fibrosis, revascularization and neural dysregulation are unique features of APN. The study findings broaden our understanding of the pathogenesis underlying APN, which provides insights into novel pathogenesis with potential therapeutic implications.
An effective points of interest recommendation approach based on embedded meta‐path of spatiotemporal data
Authors: Song Rui , Li Tong , Dong Xin , Ding Zhiming 
Published: September 2022

AbstractWith the development of mobile networks and the rapid prevalence of location‐based social networks (LBSN), a massive volume of spatiotemporal data has been generated, which is valuable for points of interest (POI) recommendation. However, current studies have not unleashed the full power of such spatiotemporal data, which either explore only a single dimension of the data or consider multiple factors in an asynchronous fashion. In this article, we propose a novel spatiotemporal network‐based recommender framework (STNBR) to effectively recommend POIs for users. Specifically, we first establish a comprehensive conceptual model of spatiotemporal data, involving various essential factors for POIs recommendation. On top of the conceptual model, we design a series of meaningful meta‐paths that simultaneously consider the time and location factors to precisely capture the semantics of user behaviours. By profiling users based on their embedded meta‐paths, our approach can yield meaningful POIs recommendations. We have evaluated our proposal using a realistic dataset obtained from Foursquare and Gowalla, the results of which show that our STNBR model outperforms existing approaches.
Marital satisfaction, parenting stress, and family alliance: Parental perspective taking as a moderator
Authors: Deschênes Marie , Bernier Annie , Cyr Chantal , Paradis Alison , Rassart Camille‐Andrée 
Published: September 2022

AbstractResearch has shown that family alliance (FA), operationalized as the quality of mother–father‐child triadic interactions, is important for child socioemotional development. However, few studies have investigated the predictors of FA, and there are few longitudinal studies available. Accordingly, this study first examined whether mothers' and fathers' marital satisfaction and parenting stress during infancy predicted FA five years later, when their children entered kindergarten. Second, the moderating role of both parents' perspective‐taking capacity as a moderator of these longitudinal associations was examined. The study was conducted with 113 intact families (mother–father‐child). Marital satisfaction, parenting stress, and perspective taking were reported by both parents and FA was assessed by observation. Contrary to expectations, neither parent's marital satisfaction or parenting stress was directly related to family alliance. However, significant moderating effects were found for both parents' perspective taking, such that higher paternal and maternal parenting stress predicted poorer FA only among parents with relatively lower perspective‐taking capacities. These findings suggest that some aspects of the quality of family interactions when children enter school can be predicted by mothers' and fathers' personal dispositions assessed as early as five years prior.