bluuebunny/crossref_metadata_2025_split huggingface dataset:
Participatory budgeting and climate change: a bibliometric analysis
Authors: Rocha Gleidcy Helle dos Helle dos Reis , Costa Claúdia 
Published: March 2022

Abstract
Climate change is an undeniable and tangible reality with consequences that have gradually become more serious, for this reason, is necessary to find tools to prevent further damage from occurring. In this context that the Participatory Budget fits, which over the last few years, has been commonly used as a tool for mitigating and adapting to climate change. Thereupon, the scope of this study is to carry out a mapping of academic production related to participatory budgeting and climate change. For this purpose, we chose to use bibliometric techniques, using two software: Bliblioshiny by Bibliometrix and Vosviewer, making it possible to analyze citations, co-citations and text of articles obtained from Scopus and Web of Science databases. As for the results, it was possible to observe that despite the imminent need to study the themes, there is a tiny amount of works, indicating that there is still much to be done.
Trajectory Planning for UAV Navigation in Dynamic Environments with Matrix Alignment Dijkstra
Authors: Wang Jinyang , Li Yuhua , Li Ruixuan , Chen Hao , Chu Kejing 
Published: March 2022

Abstract
The trajectory planning for UAVs in the dynamic environments is a challenging task. Many restrictions should be taken into consideration, including dynamic terrain collision, no-fly zone criteria, power and fuel criteria and so on. However, some methods treat dynamic restrictions as static in order to reduce cost and obtain efficient and acceptable paths. To achieve optimal, efficient and acceptable paths, we first use a high-dimension matrix, Extended Hierarchical Graph (EHG), to model the unexplored dynamic grid environment and to convert weather conditions to passable coefficient. The original shortest path planning task is then translated to plan the safest path. Therefore, we propose a new forward-exploration and backward-navigation algorithm, Matrix Alignment Dijkstra (MAD), to pilot UAVs. We use matrix alignment operation to simulate the parallel exploration process of all cells from time t to t+1. This exploration process can be accelerated on a GPU. Finally, we recall the optimal path according to the navigator matrix. In addition, we can achieve UAV path planning from one source cell to multiple target cells within one single run. We validate our method on a real dynamic weather dataset and get competitive results in both efficiency and accuracy. We analyse the performance of MAD on a grid-based benchmark dataset and artificial maze data. Simulated results show MAD is especially helpful when the grid-based environment is large-scale and dynamic.
Quality assurance and improvement in oncology using guideline-derived quality indicators –results of the Gynaecological Cancer Centers certified by the German Cancer Society (DKG)
Authors: Griesshammer Ellen , Wesselmann Simone , Beckmann Matthias W. , Dannecker Christian , Wagner Uwe , Sibert Nora Tabea , Armbrust Robert , Sehouli Jalid 
Published: March 2022

Abstract
Purpose: On the example of Gynaecological Cancer Centres (GCCs) certified by the German Cancer Society, this study evaluates results of medical guideline derived quality indicators (QIs) for cervical cancer (CC) and ovarian cancer (OC), examines how implementation of the indicators developed over the course-of-time, status of the guideline-compliant-care and identifies improvement measures.Methods: QI results for patients with CC and OC treated in GCCs between 2015-2019 are analysed. The QIs median, overall proportion and standard deviation were calculated. Two-sided Cochran-Armitage tests were applied.Results: QIs are divided in two categories: process-organization (PO-QIs) and treatment-procedures (TP-QIs), to allow a differentiated analysis for identifying improvement measures.PO-QIs that reflect the implementation of processes and structures show a high application. PO-QIs have tremendous influence on the quality of care, while being easy implementable through SOPs.TP-QIs report on treatments that are performed in the GCC.TP-QIs that report on systemic-therapies reach a plateau where the guideline is known, but patient-related-reasons meaningfully prevent further increase. TP-QIs that report on surgical interventions fluctuate. Most relevant factors are practitioners’ personal skills. Besides the discussion of results amongst peers during the audit, improvement measures could include surgical courses or coaching.Conclusion: The analysis shows that a combination of different measures is necessary to anchor quality sustainably in health care and thus improve it.
Geometric Origin of Intrinsic Spin Hall Effect in an Inhomogeneous Electric Field
Authors: Zhang Anwei , Rhim Jun-Won 
Published: March 2022

Abstract
In recent years, the spin Hall effect has been received great attention because of its potential application in spintronics and quantum information processing and storage. However, this effect is usually studied under the external homogeneous electric field. Understanding how the inhomogeneous electric field affects the spin Hall effect is still lacking. Here, we give the general expression for the intrinsic spin Hall conductivity in the presence of the inhomogeneous electric field, which is shown to be expressed through gauge-invariant geometric quantities. On the other hand, when people get physical intuition on transport phenomena from the wave packet, one issue appears. It is shown that the conductivity obtained from the conventional wave packet approach cannot be fully consistent with the one predicted by the Kubo-Greenwood formula. Here, we attempt to solve this problem.
Ask the shark: Blackmouth catshark (Galeus melastomus) as a sentinel of plastic waste on the seabed
Authors: Sbrana Alice , Cau Alessandro , Cicala Davide , Franceschini Simone , Giarrizzo Tommaso , Gravina Maria Flavia , Ligas Alessandro , Maiello Giulia , Matiddi Marco , Parisi Antonio , Sartor Paolo , Sbrana Mario , Scacco Umberto , Valente Tommaso , Viva Claudio , Russo Tommaso 
Published: March 2022

Abstract
The presence of plastic waste in the marine environment has driven the scientific community to make significant efforts to study and mitigate its possible effects. One of the critical aspects is to determine if and how an increase in ingestion events may occur as a result of the accumulation of plastic waste on the seabed. In this study, G. melastomus is examined for its ability to indirectly provide information on the amount of macroplastics accumulating on the seafloor. Plastic ingestion is explored by describing the feeding habits of the species, which have the potential to provide very useful information regarding biological or ecological issues. The diet of G. melastomus mainly consisted of cephalopods, bathypelagic fishes, and decapod crustaceans, increasing in diversity during growth. The generalist-opportunistic feeding behaviour of this species leads to the incidental ingestion of plastic particles (N= 47, with a mean (± SD) of 1.47 ± 0.28 per specimen) which can be indirectly associated to the presence of macroplastics on the seafloor. Indeed, our results indicate a significant relationship between the amount of macroplastics present on the seabed and the frequency of ingestion of plastic particles by blackmouth catshark. We propose G. melastomus as an excellent candidate for developing a valid monitoring strategy for the presence of plastics on the seabed, as requested by the EU Marine Strategy Framework Directive.
Acinetobacter Baumannii Response to Cefiderocol Challenge in Human Urine
Authors: Nishimura Brent , Escalante Jenny , Tuttobene Marisel R. , Subils Tomás , Mezcord Vyanka , Pimentel Camila , Georgeos Nardin , Pasteran Fernando , Rodriguez Cecilia , Actis Luis A. , Tolmasky Marcelo E. , Bonomo Robert A. , Ramirez María Soledad 
Published: March 2022

Abstract
Cefiderocol (CFDC) is a novel chlorocatechol-substituted siderophore cephalosporin, approved by the Food and Drug Administration (FDA) for treating complicated urinary tract infections and for hospital-acquired and ventilator-acquired pneumonia. In previous work, human serum, human serum albumin,HSA, and human pleural fluid, HPF, were shown to increase the minimum inhibitory concentration (MICs) of Acinetobacter baumannii against CFDC. These fluids are also associated with a reduction in the expression of genes related to iron uptake systems, which could explain the need for higher concentrations of CFDC to exert inhibitory action. Herein, we analyzed the impact of human urine (HU), which contains low albumin concentrations, on the expression of iron-uptake related genes and MIC values of two carbapenem-resistant A. baumannii. Levels of resistance to CFDC were not modified by HU in strain AMA40 but were reduced in the case of strain AB5075. Testing other carbapenem-resistant A. baumannii isolates showed that the CFDC MICs were unmodified or reduced in the presence of HU. The expression of piuA, pirA, bauA, and bfnH determined by qRT-PCR was enhanced in both strains when HU was present in the culture medium. All four tested genes are involved in recognizing ferric siderophore complexes or internalization into the cell’s cytosol. In contrast, the effect of HU on genes associated with resistance to β-lactams, antibiotics commonly used to treat urinary tract infections caused by A. baumannii, was variable; the transcriptional analysis of pbp1, pbp3, blaOXA−51−like, blaADC, and blaNDM−1 showed significant variation. In summary, HU, probably due to the albumin and free iron content, does not adversely impact or slightly improves the activity of CFDC when tested against A. baumannii in urine in contrast to other human bodily fluids.
Selective Sphingosine-1-phosphate Receptor 1 Modulator Attenuates Blood–brain Barrier Disruption Following Traumatic Brain Injury by Inhibiting Vesicular Transcytosis
Authors: Zhang Yuan , Wang Lin , Pan Qiuling , Yang Xiaomin , Cao Yunchuan , Yan Jin , Wang Yingwen , Tao Yihao , Fan Runjin , Sun Xiaochuan , Li Lin 
Published: March 2022

Abstract
BackgroundTraumatic brain injury (TBI) provokes secondary pathological damage, such as damage to the blood–brain barrier (BBB), ischaemia and inflammation. Major facilitator superfamily domain-containing 2a (Mfsd2a) has been demonstrated to be critical in limiting the increase in BBB vesicle transcytosis following brain injury. Recent studies suggest that a novel and selective modulator of the sphingosine-1-phosphate receptor 1 (S1P1), CYM-5442, maintains the integrity of the BBB by restricting vesicle transcytosis during acute ischaemic stroke. In the current study, we investigated whether CYM-5442, evaluated in a short-term study, could protect the brains of mice with acute-stage TBI by reversing the increase in vesicle transport due to reduced mfsd2a expression after TBI.MethodsWe used the well-characterized model of TBI caused by controlled cortical impact. CYM-5442 (0.3, 1, 3 mg/kg) was intraperitoneally injected 30 min after surgery for 7 consecutive days. To investigate the effect of CYM-5442 on vesicle transcytosis, we downregulated and upregulated Mfsd2a expression using a specific AAV prior to evaluation of the TBI model. MRI scanning, cerebral blood flow, circulating blood counts, ELISA, TEM, WB, and immunostaining evaluations were performed after brain injury.ResultsCYM-5442 significantly attenuated neurological deficits and reduced brain oedema in TBI mice. CYM-5442 transiently suppressed lymphocyte trafficking but did not induce persistent lymphocytopenia. After TBI, the levels of Mfsd2a were decreased significantly, while the levels of CAV-1 and albumin were increased. In addition, Mfsd2a deficiency caused inadequate sphingosine-1-phosphate (S1P) transport in the brain parenchyma, and the regulation of BBB permeability by Mfsd2a after TBI was shown to be related to changes in vesicle transcytosis. Downregulation of Mfsd2a in mice markedly increased the BBB permeability, neurological deficit scores, and brain water contents after TBI. Intervention with CYM-5442 after TBI protected the BBB by significantly reducing the vesicle transcytosis of cerebrovascular endothelial cells.ConclusionIn addition to transiently suppressing lymphocytes, CYM-5442 alleviated the neurological deficits, cerebral edema and protective blood–brain barrier permeability in TBI mice by reducing the vesicle transcytosis of cerebrovascular endothelial cells.
A cowpea severe mosaic virus-based vector bolsters virus-induced gene silencing and foreign protein expression in soybean
Authors: Zaulda Fides Angeli , Yang Seung Hyun , Han Junping , Mlotshwa Sizolwenkosi , Dorrance Anne , Qu Feng 
Published: March 2022

Abstract
Background: Soybean gene functions cannot be easily interrogated through transgenic disruption (knock-out) of genes-of-interest, or transgenic overexpression of proteins-of-interest, because soybean transformation is time-consuming and technically challenging. An attractive alternative is to administer transient gene silencing or overexpression with a plant virus-based vector. However, existing virus-induced gene silencing (VIGS) and/or overexpression vectors suitable for soybean have various drawbacks that hinder their widespread adoption. Results: We describe the development of a new vector based on cowpea severe mosaic virus (CPSMV), a plus-strand RNA virus with its genome divided into two RNA segments, RNA1 and RNA2. This vector, designated FZ, incorporates a cloning site in the RNA2 cDNA, permitting insertion of nonviral sequences. When paired with an optimized RNA1 construct, FZ readily infects both Nicotiana benthamiana and soybean. As a result, FZ constructs destined for soybean can be first delivered to N. benthamiana in order to propagate the modified viruses to high titers. FZ-based silencing constructs induced robust silencing of phytoene desaturase genes in N. benthamiana, multiple soybean accessions, and cowpea. Meanwhile, FZ supported systemic expression of fluorescent proteins mNeonGreen and mCherry in N. benthamiana and soybean. Finally, FZ-mediated expression of the Arabidopsis transcription factor MYB75 caused N. benthamiana to bear brown leaves and purple, twisted flowers, indicating that MYB75 retained the function of activating anthocyanin synthesis pathways in a different plant. Conclusions: The new CPSMV-derived FZ vector provides a convenient and versatile soybean functional genomics tool that is expected to accelerate the characterization of soybean genes controlling crucial productivity traits.
Head‑to‑head assessment of 68Ga-DOTA-FAPI-04 PET/CT vs 18 F-FDG PET/CT in fibroblastic tumors
Authors: Zhang Annan , Meng Xiangxi , yao Yan , Zhou Xin , Zhang Yan , Li Nan 
Published: March 2022

Abstract
Purpose: We aimed to evaluate 68Ga-DOTA-FAPI-04 PET/CT versus 18F-FDG PET/CT in the application of fibroblastic tumors.Methods: Twenty patients with 6 subtypes of fibroblastic tumors prospectively underwent 18F-FDG and 68Ga-DOTA-FAPI-04 PET/CT examinations to evaluate the lesions. PET/CT findings were confirmed by surgical pathology, puncture biopsy, or imaging follow-up. Two independent sample t tests were used to compare the uptake of 18F-FDG vs. 68Ga-DOTA-FAPI-04 in primary, recurrent and metastatic lesions. One-way ANOVA was used to compare the uptake of 18F-FDG or 68Ga-DOTA-FAPI-04 among primary, recurrent, and metastatic lesions. The uptake of 68Ga-DOTA-FAPI-04 vs. 18F-FDG in different histopathological lesions was compared by two independent sample t tests.Results: Twenty patients were finally confirmed to have 38 lesions. Although there was no significant difference in the detection of all lesions between 68Ga-DOTA-FAPI-04 and 18F-FDG PET/CT (38 vs. 36, p=0.493), the uptake of 68Ga-DOTA-FAPI-04 in lesions was significantly higher than that of 18F-FDG (p<0.001), including primary (p<0.001), recurrent (p=0.018) and metastatic (p<0.001) lesions. The SUVmax of 68Ga-DOTA-FAPI-04 in primary and recurrent lesions was higher than that in metastasis (p=0.034 and p=0.015, respectively). The SUVmax of 68Ga-DOTA-FAPI-04 in primary and recurrent malignant lesions was significantly higher than that of the intermediate (p<0.001). The SUVmax of 18F-FDG in solitary fibrous tumors (SFTs) was significantly lower than that in non-SFT lesions (p=0.029). The SUVmax of 68Ga-DOTA-FAPI-04 in one case of recurrent SFT with 5 lesions was significantly lower after treatment than before treatment (p =0.016).Conclusion: 68Ga-DOTA-FAPI-04 outperformed 18F-FDG PET/CT in displaying the primary, recurrent and metastatic lesions of fibroblastic tumors. 68Ga-DOTA-FAPI-04 PET/CT may also show potential value for judging the nature and monitoring the therapeutic response of tumors.
Two miRNAs Efficiently Reprogram Human Fibroblasts into SST Interneurons
Authors: Gu Xi , Wang Junhao , Jiang Xiaodan 
Published: March 2022

Abstract
Many neurological disorders stem from defects in or the loss of specific neurons. Dysfunction of γ-aminobutyric acid (GABA)ergic interneurons may cause a variety of neurological and psychiatric disorders such as epilepsy, autism, Alzheimer's disease and depression. Unlike other types of neurons, which can be generated relative easily by direct reprogramming, it is difficult to generate GABAergic neurons by traditional methods. Neuronal transdifferentiation of fibroblasts mediated by nongenomic-integrate adenovirus has many advantages, but the efficiency is low, and there is a lack of studies using human cells as the initial martials. In this study, we explored the feasibility of conversion of human fibroblasts into neurons through adenovirus-mediated gene expression, and found that by introducing two microRNAs, miR-124 and let-7, can effectively generate GABAergic neuron-like cells from human neonatal fibroblasts without reverting to a progenitor cell stage. Most of these cells expressed neuronal markers and were all somatostatin (SST) positive cells. Therefore, our study provides a relatively safe and efficient method to generate SST interneurons.
A New Marker Constructed From Immune-related lncRNA Pairs Can be Used to Predict Clinical Treatment Effects and Prognosis: in-depth Exploration of Underlying Mechanisms in HNSCC
Authors: Fan Xin , Zhong Yun , Yan Yujie , Li Jiaqi , Xie Fei , Zhang Zhiyuan 
Published: March 2022

Abstract
Background: LncRNA plays a vital role in tumor proliferation, migration, and treatment. Since it is difficult for the gene expression levels detected by different platforms to reach the same standard, the signatures composed of many immune-related single lncRNAs are still inaccurate. Using two immune-related lncRNAs to form a gene pair and cleverly assigning values can effectively meet the demand for a higher-accuracy dual biomarker combination. Methods: Co-expression and differential expression analysis were performed on immune genes and lncRNAs data from The Cancer Genome Atlas and the ImmPort database to obtain differentially expressed immune-related lncRNAs for pairwise pairing. The prognostic-related differentially expressed immune-related lncRNAs (PR-DE-irlncRNAs) pairs were then identified by univariate cox regression and used for lasso regression to create a prognostic model. Various methods were used to validate the predictive prognostic performance of the model. We also explored the potential guiding value of the model in immunotherapy and chemotherapy and constructed a nomogram suitable for efficient prognosis prediction. Mechanistic exploration of anti-tumor immunity and mutational perspectives are also included. We also analyzed the correlation between the model and immune checkpoint inhibitors (ICIs)-related, m6a-related, and multidrug resistance genes. Results: We used a total of 20 PR-DE-irlncRNAs pairs to create a prognosis model. Various methods have verified the model's excellent performance in predicting the prognosis of patients. We reasoned that lncRNAs/ TP53 mutation might play a positive/ negative anti-tumor role through the immune system through multi-perspective analysis. Finally, the prognostic model has been found to be closely related to immunotherapy and chemotherapy and the expression of ICIs/M6A/multidrug resistance-related genes.Conclusion: The prognostic model has an excellent performance in predicting the prognosis of patients, as well as the potential value of practical guidance for treatment.
Ocean-wave phenomenon around Japan Island due to the 2022 Tonga eruption observed by the wide and dense ocean-bottom pressure gauge networks
Authors: Kubo Hisahiko , Kubota Tatsuya , Suzuki Wataru , Aoi Shin , Sandanbata Osamu , Chikasada Naotaka , Ueda Hideki 
Published: March 2022

Abstract
Ocean-bottom pressure gauges of wide and dense ocean-bottom observation networks in Japan, S-net and DONET, observed ocean waves due to the Tonga eruption that occurred at approximately 13:00 JST (UTC + 9) on January 15, 2022. We scrutinized their waveform records to clarify the nature of the arriving ocean waves, and found two significant disturbances between 20:00–21:00 and after 22:00. The first disturbance with a positive-polarity pulse and significant long-period components (1000–3000 s) arrived at S-net and DONET stations between 20:00–21:00 from the southeast, corresponding to the direction of the great circle of Tonga as seen from Japan. This arrival was much earlier than expected for a direct tsunami from the volcano and can be explained by assuming the propagation along the great circle path between Japan and Tonga at a velocity of approximately 300 m/s. After 22:00, significant phases dominated by relatively shorter period components (< 1000 s) arrived from the southeast direction in both observation networks. In DONET, another phase arrived from the south-southeast direction at approximately 23:30 with significant shorter period components (approximately 500 s). Most of the near-trench S-net stations recorded a peak amplitude during the first disturbance, whereas the near-coast S-net stations and DONET stations observed their peak after 22:00. The amplitudes of ocean-bottom pressure change were amplified as the water depth decreases. This amplification behavior differed between the first and second disturbances, and it may have been caused by differences in the dominant period of the arriving ocean waves, as well as differences in their generation mechanisms. This study also found several arrivals of air-wave disturbances that were correlated with the ocean-wave phases, which implies that the multiple disturbances of ocean-bottom pressure were generated by the interactions of several atmospheric pressure waves following the 2022 Tonga eruption with ocean waves.