bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indicators of central sensitization in chronic neuropathic pain after spinal cord injury
Authors: Lütolf Robin , Rosner Jan , Curt Armin , Hubli Michèle 
Published: August 2022

AbstractBackgroundCentral sensitization is considered a key mechanism underlying neuropathic pain (NP) after spinal cord injury (SCI).MethodsTwo novel proxies for central sensitization were investigated in thoracic SCI subjects with (SCI‐NP) and without NP (SCI‐nonNP) compared to healthy controls (HC). Specifically, temporal summation of pain (TSP) was investigated by examining pain ratings during a 2‐min tonic heat application to the volar forearm. Additionally, palmar heat‐induced sympathetic skin responses (SSR) were recorded in order to reveal changes in pain‐autonomic interaction above the lesion level. Pain extent was assessed as the percentage of the body area and the number of body regions being affected by NP.ResultsEnhanced TSP was observed in SCI‐NP (+66%) compared to SCI‐nonNP (−75%, p = 0.009) and HC (−59%, p = 0.021). In contrast, no group differences were found (p = 0.685) for SSR habituation. However, pain extent in SCI‐NP was positively correlated with deficient SSR habituation (body area: r = 0.561, p = 0.024; body regions: r = 0.564, p = 0.023).ConclusionsThese results support the value of TSP and heat‐induced SSRs as proxies for central sensitization in widespread neuropathic pain syndromes after SCI. Measures of pain‐autonomic interaction emerged as a promising tool for the objective investigation of sensitized neuronal states in chronic pain conditions.SignificanceWe present two surrogate readouts for central sensitization in neuropathic pain following SCI. On the one hand, temporal summation of tonic heat pain is enhanced in subjects with neuropathic pain. On the other hand, pain‐autonomic interaction reveals potential advanced measures in chronic pain, as subjects with a high extent of neuropathic pain showed diminished habituation of pain‐induced sympathetic measures. A possible implication for clinical practice is constituted by an improved assessment of neuronal hyperexcitability potentially enabling mechanism‐based treatment.
Study of clay degradation in an earthslide combining OBIA and roughness analysis of UAV‐based optical images
Authors: Fiolleau Sylvain , Jongmans Denis , Bièvre Grégory , Chambon Guillaume , Michel Olivier , Borgniet Laurent 
Published: August 2022

AbstractFlow‐like landslides in clay slopes pose major threats to people and infrastructure, which has led to numerous studies in recent decades. However, the mechanisms leading to the solid–fluid transition in clay are still poorly understood, despite numerous studies on its rheological evolution. The aim of this study is to contribute to quantify the degradation of clay at the surface of the Harmalière landslide (French Alps) from the analysis of a series of three unmanned aerial vehicle (UAV) acquisitions. Two approaches were combined to process the acquired optical images. First, image classification was performed applying object‐based image analysis (OBIA) to the red, green and blue (RGB) and surface roughness layers. Second, deeper analysis of the surface roughness allows to describe the morphology evolution and to interpret the degradation scheme from undegraded clay to degraded clay.The study shows that the applied methodology is appropriate to perform a thorough analysis of the material degradation pattern on the surface of a landslide. The temporal analysis shows an average degradation rate leading to the complete degradation of a block in about 2 years. Meanwhile, a spatial analysis shows that non‐degraded clays degrade faster in the lower part of the study area, reactivated 30 years ago, than in the upper part, reactivated only a few years ago. In addition, roughness analyses enabled to highlight the evolution of the morphology during the degradation process of the clay blocks, from angular blocks to mounds.
Trading cryptocurrencies using algorithmic average true range systems
Authors: Cohen Gil 
Published: August 2022

AbstractThis research makes the first attempt to design, optimize and use average true range (ATR)‐based trading systems for five popular cryptocurrencies. We used particle swarm optimization procedures to optimize systems with multiple objectives that are based on the ATR concept. Our aim was to determine the best configurations for each system that would maximize net profits, the profit factor, and the percentage of profitable trades. We demonstrate that the ATR‐based systems can predict the price trends of the examined cryptocurrencies. Our results also indicate that optimized Keltner Channel‐based systems improve the ability of the stand‐alone optimized ATR systems to forecast trends, net profits, and the profit factor. Finally, both systems perform better for long trades than for short trades.
Incentives to implement personalized medicine under second‐best pricing
Authors: Mougeot Michel , Naegelen Florence 
Published: August 2022

AbstractWe characterize the socially optimal pricing policy inducing the implementation of personalized medicine. As a benchmark, we analyze the first‐best allocation and the second‐best optimal policy when only one treatment is available. Then, we characterize the optimal policy that a Health Authority can design to induce the firm to bear an investment and testing cost allowing it to tailor treatment to patients' needs. We show how optimal prices increase with treatment quality and effectiveness. We characterize the conditions under which these prices yield higher social welfare than in the benchmark case. Moreover, we address some policy and industrial organization issues and characterize the pricing policy inducing the firm to choose the optimal level of treatment effectiveness.
Embracing universalism: The new Brazilian cross‐border insolvency regime
Authors: Campana Filho Paulo Fernando 
Published: August 2022

AbstractThis article provides an analysis of cross‐border insolvency provisions in Brazil after the enactment of a recent legislative reform incorporating the UNCITRAL Model Law on cross‐border insolvency, in the context of the country's legal tradition and territorialist history, and of the first cases ruled on the matter.
Liquiritin alleviates alpha‐naphthylisothiocyanate‐induced intrahepatic cholestasis through the Sirt1/FXR/Nrf2 pathway
Authors: Yan Miao , Guo Lin , Ma Jiating , Yang Yan , Tang Tingli , Zhang Bikui , Zhou Wei , Zou Wei , Hou Zhenyan , Gu Hongmei , Gong Hui 
Published: August 2022

AbstractLiquiritin (LQ) is an important monomer active component in flavonoids of licorice. The objective of this study was to evaluate the hepatoprotective effects of LQ in cholestatic mice. LQ (40 or 80 mg/kg) was intragastrically administered to mice once daily for 6 days, and mice were treated intragastrically with a single dosage of ANIT (75 mg/kg) on the 5th day. On the 7th day, mice were sacrificed to collect blood and livers. The mRNA and protein levels were determined by qRT‐PCR and western blot assay. We also conducted systematical assessments of miRNAs expression profiles in the liver. LQ ameliorated ANIT‐induced cholestatic liver injury, as evidenced by reduced serum biochemical markers and attenuated pathological changes in liver. Pretreatment of LQ reduced the increase of malondialdehyde, TNF‐α, and IL‐1β induced by ANIT. Moreover, ANIT suppressed the expression of Sirt1 and FXR in liver tissue, which was weakened in the LQ pre‐treatment group. LQ enhanced the nuclear expression of Nrf2, which was increased in the ANIT group. LQ also increased the mRNA expressions of bile acid transporters Bsep, Ntcp, Mrp3, and Mrp4. Furthermore, a miRNA deep sequencing analysis revealed that LQ had a global regulatory effect on the hepatic miRNA expression. Kyoto Encyclopedia of Genes and Genomes functional enrichment analysis showed that the differentially expressed miRNAs were mainly related to metabolic pathways, endocytosis, and MAPK signaling pathway. Collectively, LQ attenuated hepatotoxicity and cholestasis by regulating the expression of Sirt1/FXR/Nrf2 and the bile acid transporters, indicating that LQ might be an effective approach for cholestatic liver diseases.
Methodology for the Guidelines on Evaluation and Management of Hypoparathyroidism and Primary Hyperparathyroidism
Authors: Yao Liang , Guyatt Gordon , Ye Zhikang , Bilezikian John P. , Brandi Maria Luisa , Clarke Bart L. , Mannstadt Michael , Khan Aliya A. 
Published: August 2022

ABSTRACT
To develop guidelines for hypoparathyroidism and primary hyperparathyroidism, the panel assembled a panel of experts in parathyroid disorders, general endocrinologists, representatives of the Hypoparathyroidism Association, and systematic review and guideline methodologists. The guideline panel referred to a formal process following the Recommendations, Assessment, Development, and Evaluation Working Group (GRADE) methodology to issue GRADEd recommendations. In this approach, panelists and methodologists formatted the questions, conducted systematic reviews, evaluated risk of bias, assessed certainty of evidence, and presented a summary of findings in a transparent fashion. For most recommendations, the task forces used a less structured approach largely based on narrative reviews to issue non-GRADEd recommendations. The panel issued Eight GRADEd recommendations (seven for hypoparathyroidism and one for hyperparathyroidism). Each GRADEd recommendation is linked to the underlying body of evidence and judgments regarding the certainty of evidence and strength of recommendations, values and preferences, and costs, feasibility, acceptability and equity. This article summarizes the methodology for issuing GRADEd and non-GRADEd recommendations for patients with hypoparathyroidism or hyperparathyroidism. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Extracellular vesicle‐packaged miR‐181c‐5p from epithelial ovarian cancer cells promotes M2 polarization of tumor‐associated macrophages via the KAT2B/HOXA10 axis
Authors: Yang Shuyan , Zhao Honghui , Xiao Wei , Shao Lei , Zhao Chunyan , Sun Pengcheng 
Published: August 2022

AbstractObjectivesThe molecular mechanistic actions of tumor‐derived extracellular vesicles (EVs) in modulating macrophage polarization in the tumor microenvironment of epithelial ovarian cancer (EOC) is largely unknown. The study was performed to clarify the effect and downstream mechanism of microRNA‐181c‐5p (miR‐181c‐5p)‐containing EVs from EOC cells in the M2 polarization of tumor‐associated macrophages (TAMs).MethodsEVs were isolated from normoxic and hypoxic human EOC cells SKOV3. Human mononuclear cell THP‐1 was induced by phorbol‐12‐myristate‐13‐acetate to differentiate into TAMs. The targeting relationship between miR‐181c‐5p and KAT2B was verified by dual luciferase reporter gene assay. The interaction between KAT2B and HOXA10 was detected by immunofluorescence, Co‐IP and ChIP assays. EdU staining, the scratch test and Transwell assay were used to assess the resultant cell proliferation, migration and invasion. The mouse xenograft model and the pulmonary metastasis model were developed through intraperitoneal injection of SKOV3 cells and tail vein injection of THP‐1 cells, respectively.ResultsHypoxic SKOV3 cell‐derived EVs could be internalized by TAMs. SKOV3 cell‐derived EVs induced by hypoxia (H‐EVs) promoted M2 polarization of TAMs and facilitated the proliferation, migration and invasion of SKOV3 cells. miR‐181c‐5p was highly expressed in H‐EVs and promoted the M2 polarization of TAMs. Further, miR‐181c‐5p targeted KAT2B, upregulated HOXA10 and activated the JAK1/STAT3 pathway, thereby promoting the M2 polarization of TAMs. In both mouse models, H‐EV‐derived miR‐181c‐5p promoted growth and metastasis of EOC cells.ConclusionThe miR‐181c‐5p‐containing EVs from hypoxic EOC cells may upregulate HOXA10 by targeting KAT2B and activate the JAK1/STAT3 pathway to promote the M2 polarization of TAMs, ultimately promoting growth and metastasis of EOC cells in vitro and in vivo.
Radiographic technique modification and evidence‐based practice: A qualitative study
Authors: Rawle Marnie , Pighills Alison , Mendez Diana , Dobeli Karen 
Published: August 2022

AbstractIntroductionEvidence‐based practice in radiography is an emerging practice, due to a lack of evidence. Beyond the diagnostic requirements of the examination, imaging technique decisions are guided by the radiographer's tertiary education and clinical experience. Imaging technique decisions should include all aspects of evidence‐based practice: research‐based evidence, patient circumstances and clinical experience. Previous research suggests radiographers do to not fully engage with the latter, which may jeopardise progress in the field and lead to outdated practices and suboptimal outcomes for patients. This study aimed to examine the motivators and influences involved in radiographers' decision‐making when modifying imaging acquisition techniques.MethodsAn exploratory descriptive, inductive qualitative interview‐based design was used with a convenience sample of radiographers from three public hospital sites in Queensland. Twelve one‐on‐one semi‐structured interviews were performed via video conference, the data were analysed through thematic analysis.ResultsFive themes emerged from the data: advancement of technology; experience rather than evidence; radiology's influence on radiographic practice; information sources; and image quality. The pursuit of image quality was the key motivator and criterion that influenced radiographers' choices in imaging technique modification. Interviewees did not engage routinely with research‐based evidence, preferring to rely on empirical observations and professional experience.ConclusionThe exclusion of research‐based evidence can lead to outdated and ineffective clinical decisions. Further work is needed to promote more research in the field of radiography and increase the willingness and capacity of radiographers to follow the principles of evidence‐based practice.
Miniaturized VHF‐band LTCC balun using L‐C surrounded resonator
Authors: Hu Shanwen , Wang Yu , Xu Cuihua , Zhou Bo 
Published: August 2022

AbstractA miniaturized lumped‐element balun is proposed for the very high frequency band applications. The miniaturization is accomplished by the inductor–capacitor (L‐C) surrounded resonator, which places a vertically interdigital‐capacitor inside spiral inductor for higher integration. The L‐C surrounded resonator only takes up one element's area without increasing the number of substrate layers. The balun is built on a 10‐layer thickness low temperature co‐fired ceramic substrate and has the smallest reported size of only 0.004 × 0.003 × 0.0003λg. Moreover, the proposed balun also has a second‐order harmonic suppression of 40 dB. Furthermore, thermal boundary analysis, comparisons, and discussions are also implemented.
Partitioned coupling framework to combine a kinematic hardening plasticity model and a creep model for structures in a high‐temperature environment
Authors: Yusa Yasunori , Miyamura Tomoshi , Yin Jun , Koike Kuniaki , Ikeda Takashi , Yamada Tomonori 
Published: August 2022

AbstractThe present study proposes a partitioned coupling framework for the implementation of a combined kinematic hardening plasticity and creep model. In the present framework, plastic and creep implicit stress integrations are performed alternately and iteratively until convergence in a partitioned coupling manner. This approach enables us to tractably implement a constitutive model that combines a plasticity model and a creep model in the program. The present framework was applied to the combination of the Ohno–Wang plasticity model and the Norton–Bailey creep model for numerical examples. The numerical examples demonstrated the capability of the present framework in analyzing realistic structures at high temperature with the consideration of both plasticity and creep.
A dual decomposition of the closest point projection in incremental elasto‐plasticity using a mixed shell finite element
Authors: Liguori Francesco S. , Madeo Antonio , Garcea Giovanni 
Published: August 2022

AbstractMixed assumed stress finite elements (FEs) have shown good advantages over traditional displacement‐based formulations in various contexts. However, their use in incremental elasto‐plasticity is limited by the need for return mapping schemes which preserve the assumed stress interpolation. For elastic‐perfectly plastic materials and small deformation problems, the integration of the constitutive equation furnishes a closest point projection (CPP) involving all the element stress parameters. In this work, a dual decomposition strategy is adopted to split this problem into a series of CPPs at the integration points level and in a nonlinear system of equations over the element, in order to simplify its solution. The strategy is tested with a four nodes mixed shell FE, named MISS‐4, characterized by an equilibrated stress interpolation which improves the accuracy. Two decomposition strategies are tested to express the plastic admissibility either in terms of stress resultants or point‐wise Cauchy stresses. The recovered elasto‐plastic solution preserves all the advantages of MISS‐4, namely it is accurate for coarse meshes in recovering the equilibrium path and evaluating the limit load showing a quadratic rate of convergence, as demonstrated by the numerical results.
Chemotherapy‐induced thrombocytopenia in pediatric oncology: Scope of the problem and opportunities for intervention
Authors: Degliuomini Melanie D. , Armstrong Katherine , Mauguen Audrey , Slotkin Emily K. , Roberts Stephen S. , Dunkel Ira J. , Clouser Mary , Ortiz Michael V. , Soff Gerald A. 
Published: August 2022

AbstractBackgroundChemotherapy‐induced thrombocytopenia (CIT) is a known hematologic complication of oncology treatment. This single‐institution study examines the degree with which CIT impacts specific pediatric solid tumor cohorts reflected by platelet transfusion burden and treatment modifications.ProcedureData regarding clinically relevant CIT were obtained via a retrospective chart review of pediatric solid tumor patients treated at Memorial Sloan Kettering Cancer Center from 2013 to 2020. Patients were stratified based on histologic diagnoses as well as chemotherapy regimen. CIT impact was assessed through platelet transfusion means, chemotherapy dose reductions, and treatment delays.ResultsA total of 150 patients were included with mean age 10.3 [0.2–21.0]. Patients receiving therapy for high‐risk neuroblastoma and localized Ewing sarcoma, both of which included high‐dose cyclophosphamide and doxorubicin, required the most platelet transfusions over the treatment course, with a mean of 13 and 9, respectively. Reduced relative dose intensity (RDI), due in part to CIT, was greatest for the patients receiving therapy for high‐risk and intermediate‐risk rhabdomyosarcoma. Fifty‐six percent of high‐risk patients experienced a reduced RDI during the final two cycles of treatment and 69% of intermediate‐risk patients experienced one during the final four cycles of treatment.ConclusionsThe impact of CIT varied by the administered chemotherapy regimens and dose intensity of chemotherapy agents. This study demonstrated that CIT causes both marked platelet transfusion burden as well as treatment reduction and delay within certain solid tumor cohorts. This can lend to future studies aimed at reducing the burden of CIT and targeting the most at‐risk populations.
Effect ofGOagglomeration on the mechanical properties of graphene oxide and nylon 66 composites and micromechanical analysis
Authors: Chen Qi , Guo Zhangxin , Cheng Feng , Chai Gin Boay , Li Yongcun , Luan Yunbo , Liang Jianguo 
Published: August 2022

AbstractNanoparticles are prone to aggregation in the matrix under the action of surface energy, chemical bonding, electrostatic attraction, and van der Waals forces. Based on the molecular dynamics method, the tensile properties of graphene oxide (GO)‐reinforced nylon 66 composites were simulated and calculated, and the stress–strain curves, atomic stress clouds, and changes in the number of hydrogen bonds were obtained for the composites under tensile loading, and the effects of GO agglomeration on the mechanical properties of GO/PA66 composites were analyzed. When the GO mass fraction accounted for 90.3%, 80.5%, and 70.6% of the model, respectively, the mechanical properties of the composites decreased by 15.4%, 4.5%, and 4.2%, respectively. Because GO agglomeration in the composites made it difficult to bond effectively between GO and PA66, the number of hydrogen bonds and the type of hydrogen bonds within the model, varied with the degree of aggregation. The changes in the number of hydrogen bonds and the type of hydrogen bonds during uniaxial stretching were simulated by molecular dynamics. The number of hydrogen bonds and the type of hydrogen bonds directly affect the mechanical properties of the composites. It can be seen from the atomic stress cloud diagram that the aggregation of GO makes the mechanical properties of GO fail to exert effectively. The main stress is on the C atoms in the outermost layer of GO, while the stress on the inner layer C atoms is relatively small. As the degree of GO agglomeration decreases, the stress on each C atom of GO lamellae tends to be uniform, which effectively brings into play the excellent mechanical properties of GO and improves the mechanical properties of the composite.
Best practices to account for capture probability and viewable area in camera‐based abundance estimation
Authors: Moeller Anna K. , Waller Scott J. , DeCesare Nicholas J. , Chitwood M. Colter , Lukacs Paul M. 
Published: August 2022

AbstractA suite of recently developed statistical methods to estimate the abundance and density of unmarked animals from camera traps require accurate estimates of the area sampled by each camera. Although viewshed area is fundamental to achieving accurate abundance estimates, there are no established guidelines for collecting this information in the field. Furthermore, while the complexities of the detection process from motion sensor photography are generally acknowledged, viewable area (the common factor between motion sensor and time lapse photography) on its own has been underemphasized. We establish a common set of terminology to identify the component parts of viewshed area, contrast the photographic capture process and area measurements for time lapse and motion sensor photography, and review methods for estimating viewable area in the field. We use a case study to demonstrate the importance of accurate estimates of viewable area on abundance estimates. Time lapse photography combined with accurate measurements of viewable area allow researchers to assume that capture probability equals 1. Motion sensor photography requires measuring distances to each animal and fitting a distance sampling curve to account for capture probability of <1.