bluuebunny/crossref_metadata_2025_split huggingface dataset:
Norepinephrine reuptake inhibitors and risk of antihypertensive treatment intensification and major adverse cardiovascular events in patients with stable hypertension and depression
Authors: Desai Raj , Park Haesuk , Brown Joshua D. , Mohandas Rajesh , Smith Steven M. 
Published: April 2022

AbstractStudy ObjectiveTo compare the risk of antihypertensive treatment intensification (TI) and major adverse cardiovascular events (MACE) with the initiation of serotonin norepinephrine reuptake inhibitors compared to selective serotonin reuptake inhibitors (SSRIs) in patients with stable hypertension and depression.DesignRetrospective cohort study.Data SourceIBM MarketScan® commercial claims database and Medicare Supplemental claims database from 2007 to 2019.PatientsPatients aged 18 years or older with stable treated hypertension and depression who newly initiate either serotonin norepinephrine reuptake inhibitors or SSRIs.InterventionSerotonin norepinephrine reuptake inhibitors versus SSRIs.Measurements and Main ResultsThe primary outcomes were: (1) TI (first occurrence of antihypertensive regimen augmentation or dose escalation); (2) MACE (first occurrence of stroke or acute myocardial infarction). Baseline risk between the two groups was balanced via 1:1 propensity score (PS) matching. A Cox proportional hazard regression model was used to estimate adjusted hazard ratio (aHR) and 95% confidence intervals (95% CI). After 1:1 PS matching, we included 19,160 patients in the study cohort (mean age: 52 years, 62% females) of which 9580 initiated serotonin norepinephrine reuptake inhibitors and 9580 initiated SSRIs. Patients who initiated serotonin norepinephrine reuptake inhibitors had 15 MACE events (incidence rate per 1000 person‐years [IR], 3.9) and 1675 TI events (IR, 540.2), compared with 17 MACE events (IR, 4.0) and 1774 TI events (IR, 518.5) in the SSRI group. The risk of TI (aHR: 1.01, [95% CI: 0.94, 1.08]) and MACE (aHR: 0.98, [95% CI: 0.49, 1.96]) did not differ among patients initiated serotonin norepinephrine reuptake inhibitors versus SSRIs.ConclusionsAmong patients with stable hypertension and depression, initiation of serotonin norepinephrine reuptake inhibitors had a similar risk of antihypertensive TI and MACE compared to initiation of SSRIs. Future study with a larger sample size is needed to confirm our findings.
Registration of seven disease‐ and pest‐resistant vegetable soybean germplasm lines
Authors: Bowen Roger , Bardeau Amanda , Schultz Sarah , Hartman Glen L. 
Published: April 2022

AbstractSoybean [Glycine max (L.) Merr.] germplasm lines LB18‐49 (Reg. no. GP‐448, PI 699118), LB18‐52 (Reg. no. GP‐456, PI 699119), LB18‐57 (Reg. no. GP‐455, PI 699120), LB18‐58 (Reg. no. GP‐454, PI 699487), LB18‐65 (Reg. no. GP‐453, PI 699488), LB18‐67 (Reg. no. GP‐452, PI 699489), and LB18‐75 (Reg. no. GP‐451, PI 699121) are large seeded, non‐genetically modified organism soybean lines ranging in maturity from maturity group (MG) 00 through MG IV. Each line contains a single gene for resistance to soybean aphid or Phytophthora root and stem rot (PRSR). LB18‐49 and LB18‐58 have resistance to soybean aphid biotype 3 (Rag1) provided by LD06‐16721. Soybean aphid resistance to biotype 2 (Rag2) was derived from LD08‐12441 for LB18‐65. LD08‐12582 provided Rag2 resistance for LB18‐52 and LB18‐57. ‘Williams 82’ was the source of the PRSR resistance gene, Rps1k, for LB18‐67 and LB18‐75. Large‐seeded cultivars ‘Tohya’ (MG 00), ‘BeSweet 2001’ (MG II), ‘Gardensoy 24’ (MG II), and ‘Gardensoy 41’ (MG IV) served as recurrent parents with pest‐resistant donor lines to develop large‐seeded, pest‐resistant soybean lines in a range of maturity groups. The combined pest resistance and large seed size, in a range of maturities, will be valuable for breeders developing large‐seeded pest‐resistant cultivars.
A comprehensive theoretical analysis on the intermolecular hydrogen bond interactions with the Lewis bases having multiple hydrogen bonding abilities
Authors: Naghani Farhad Fereydooni , Emamian Saeedreza , Zare Karim 
Published: April 2022

AbstractThis work comprehensively studies the intermolecular H … O and H … N hydrogen bonding (HB) interactions between 3H‐pyrrol‐3‐one as a computationally simple model Lewis base (LB) comprising two different basic centers (sp2hybridized O and N atoms) andhydrogen halides(Hal‐H, Hal = F, Cl, Br, and I) as common Lewis acids (LAs). In an equimolar mixture of LB and any of LAs, the formation of H … O and H … N HBs can compete with each other over the course of binary (dimer) complexation processes. Computed values of counterpoise‐corrected interaction energies (CP‐IE) together with energy decomposition analysis (EDA) through symmetry‐adapted perturbation theory (SAPT) reveal that these HBs should be classified as “weak‐to‐medium” ones which are mainly dominated with electrostatic interactions. Among many explored correlation analyses, within the binary complexes formation, the values of CP‐IE are perfectly linearly correlated with those of electron density at the bond critical points of the mentioned HBs, , leading to two different regression equations as ‐ . These equations allow that an accurate prediction of the value of CP‐IE for H … O and H … N HBs is made feasible using the value of easily and rapidly computable without an explicit (direct) calculation of the so costly CP‐IE. Such equations, also, were used to accurately and individually predict CP‐IE values in ternary (trimer) complexes where both of approximatelypairwise additiveH … O and H … N HBs can be formed at once. Moreover, in terms of the calculated values of cooperativity energies, these two HBs make each other weaken portraying an anticooperativity in the ternary complexes studied.
On friction measurements and certification of slip‐preventing materials for road freight usages
Authors: Lépine Julien , Bégin‐Drolet André 
Published: April 2022

AbstractSlip‐preventing materials are often used as tertiary packaging to improve cargo securement and simplify truck loading. There are many national and international standards on their safe usage based on the extra friction they can provide. However, it is challenging to quantify the coefficient of friction (CoF) of slip‐preventing materials. This paper presents CoFs of three slip‐preventing materials and one baseline condition measured on different surfaces and contact pressures. These measurements show interesting phenomena that affect the result variability. For instance, 60% of the pairs of surfaces tested were affected by the contact pressure. Hence, the load of the freight seems to affect performance of the slip‐preventing materials. This interaction happened in different ways such as changes in the friction mode (constant slip and stick slip at difference frequencies and magnitudes). The typical CoF values available in standards as well as standardized measurement methods do not consider very well these effects nor how to deal with high variability of CoF measurements. This can lead to either over or under CoF estimations. To overcome these limitations, this paper presents a statistical method to quantify slip‐preventing material CoFs based on variability and confidence intervals of the measurements.
Global and regional circulation trends of norovirus genotypes and recombinants, 1995–2019: A comprehensive review of sequences from public databases
Authors: Kendra Joseph A. , Tohma Kentaro , Parra Gabriel I. 
Published: April 2022

AbstractHuman noroviruses are the leading global cause of viral gastroenteritis. Attempts at developing effective vaccines and treatments against norovirus disease have been stymied by the extreme genetic diversity and rapid geographic distribution of these viruses. The emergence and replacement of predominantly circulating norovirus genotypes has primarily been attributed to mutations on the VP1 capsid protein leading to genetic drift, and more recently to recombination events between the ORF1/ORF2 junction. However, large‐scale research into the historical and geographic distribution of recombinant norovirus strains has been limited in the literature. We performed a comprehensive historical analysis on 30,810 human norovirus sequences submitted to public databases between the years 1995 and 2019. During this time, 37 capsid genotypes and 56 polymerase types were detected across 90 different countries, and 97 unique recombinant genomes were also identified. GII.4, both capsid and polymerase, was the predominately circulating type worldwide for the majority of this time span, save for a brief swell of GII.17 and GII.2 capsid genotypes and a near‐total eclipse by GII.P16, GII.P21 and GII.P31 beginning in 2013. Interestingly, an analysis of 4067 recombinants found that 50.2% (N = 2039) of all recorded sequences belonged to three recently emerged recombinant strains: GII.2[P16], GII.4[P31], and GII.4[P16]. This analysis should provide an important historical foundation for future studies that evaluate the emergence and distribution of noroviruses, as well as the design of cross‐protective vaccines.
Primary Cutaneous Adenoid Cystic Carcinoma of the Scalp: A Case Report, Immunohistochemistry and Review of the Literature
Authors: Temnithikul Bhakinai , Rungrunanghiranya Suthat , Limtanyakul Piyakan , Jerasuthat Suthep , Paige David G. 
Published: April 2022

Abstract
Primary cutaneous adenoid cystic carcinoma (PCACC) is an uncommon adnexal skin tumour with fewer than 200 cases studied in detail in the English literature. We describe the diagnosis and treatment of a few Southeast Asian cases of PCACC on the scalp of a 70-year-old Thai female. She presented with a slow-growing, painless, solid to cystic, skin-coloured tumour on her scalp. When excisional biopsy was done, histopathological findings showed dermal tumour that had a classic histologic appearance composed of basaloid cells arranged in a cribriform pattern with ‘punched-out’ pseudocysts filled with mucin (swiss cheese pattern) and had perineural invasion. The clinical and histopathological findings, and complete investigations confirmed the diagnosis of PCACC. Our case illustrates that PCACC, is an important histopathological differential diagnosis to bear in mind due to its locally aggressive nature and tendency to recur due to perineural invasion. A wide local excision with at least 2 cm of tumour-free margins was performed, which revealed no residual carcinoma. The patient remained disease-free for 16 months after diagnosis. PCACC is usually located on the head or neck of people in their sixth decade of life, with a female predominance. The aetiology of PCACC is unclear. The majority of PCACCs have the MYB-NFIB fusion gene or show overexpression of MYB by immunohistochemistry. Diagnosis of PCACC is primarily based on the characteristic histological appearance, as there are no distinguishing clinical features. The diagnosis of PCACC requires careful exclusion of infiltration or metastasis from other primary lesions. Treatment of this rare tumour is wide surgical excision with at least 2 cm of tumour-free margins to reduce the risk of local recurrence, and long-term follow-up for possible recurrence of PCACC is recommended. This case emphasizes the importance of careful inspection for the diagnosis of PCACC after initial surgery and pathological evaluation of the mass lesion for appropriate diagnosis and therapy.
Ultrastable and High‐Rate 2D Siloxene Anode Enabled by Covalent Organic Framework Engineering for Advanced Lithium‐Ion Batteries
Authors: Zhang Yuchan , Wu Yang , An Yongling , Wei Chuanliang , Tan Liwen , Xi Baojuan , Xiong Shenglin , Feng Jinkui 
Published: April 2022

AbstractSiloxene as a new type of 2D material has wide potential applications due to its special structure. Especially, as anode for lithium‐ion batteries, siloxene shows promising prospect due to its small volume change and low diffusion pathway. However, the unstable solid electrolyte interphase and low electronic conductivity lead to the low Coulombic efficiency, poor rate capability, and limited cycling performance. To settle the problems, a thin porous covalent organic framework (COF) coating layer is designed by in situ growth on micro‐sized siloxene. With the inherent ionic conductive and electrolyte compatible advantages of COF, the engineered siloxene demonstrates superior electrochemical performance with 96% capacity retention at 8 A g−1 for 1500 cycles.
Robust Ruddlesden‐Popper phase Sr3Fe1.3Mo0.5Ni0.2O7‐δ decorated with in‐situ exsolved Ni nanoparticles as an efficient anode for hydrocarbon fueled solid oxide fuel cells
Authors: Zhang Xiaoyu , Tong Yawen , Liu Tong , Zhang Dong , Yu Na , Zhou Jian , Li Yueqin , Gu Xiang‐Kui , Wang Yao 
Published: April 2022

AbstractA highly efficient Ruddlesden‐Popper structure anode material with a formula of Sr3Fe1.3Mo0.5Ni0.2O7‐δ (RP‐SFMN) has been developed for hydrocarbon fueled solid oxide fuel cells (HF‐SOFC) application. It is demonstrated that a nanostructured RP‐SFMN anode decorated with in‐situ exsolved Ni nanoparticles (Ni@RP‐SFMN) has been successfully prepared by annealing the anode in reducing atmosphere similar to the operating conditions. The phase compositions, valence states, morphologies, and electrocatalytic activities of RP‐SFMN material have been characterized in detail. In addition, the in‐situ exsolution mechanism of the metallic Ni phase from the parent oxide is clearly explained by using density function theory calculation. The peak output power density at 800°C is significantly enhanced from 0.163 to 0.409 W/cm2 while the electrode polarization resistance is effectively lowered from 0.96 to 0.30 Ω cm2 by the substitution of B‐site Fe by Ni, which is attributed to the improved electrocatalytic activities induced by the in‐situ exsolved Ni nanocatalysts. Moreover, the single cell with RP‐SFMN anode exhibits good stability in 3% H2O humidified H2 and syngas for 110 and 60 h at 800°C, respectively. Our findings indicate that RP‐SFMN is a greatly promising anode candidate of HF‐SOFCs due to its good electrochemical performance and stability during the operation.
Acute stroke-like deficits associated with nonketotic hyperglycemic hyperosmolar state: an illustrative case and systematic review of literature
Authors: Rossi Simone , Romoli Michele , Urbinati Giacomo , Benini Matteo , Russo Michele , D’Anna Lucio , Abu-Rumeileh Samir , Sacco Simona , Querzani Pietro , Foschi Matteo 
Published: April 2022

AbstractIntroductionNonketotic hyperglycemic hyperosmolar state (NKHHS) is associated with a wide spectrum of neurological syndromes including acute stroke-like deficits. Clinical features and etiology have not been established yet.MethodsHere we provide a case illustration and systematic review on non-epileptic acute neurological deficits in NKHSS. The systematic literature search followed PRISMA guidelines and a predefined protocol, including cases of NKHSS with acute stroke-like presentation.ResultsThe database search yielded 18 cases. Hemianopia was the most common clinical presentation (73%), followed by partial or total anterior circulation syndrome (26%). Patients with symptoms of acute anterior circulation infarct were significantly older (69.5 ± 5.1 vs. 52.2 ± 13.9 years;p = 0.03) and showed higher mean glucose levels at the admission vs. those with hemianopia (674.8 ± 197.2 vs. 529.4 ± 190.8 mg/dL;p = 0.16). Brain MRI was performed in 89% of patients, resulting abnormal in 71% of them, especially hemianopic (91%). Subcortical hypointensities in T2-FLAIR MR sequences were present in all the analyzed cases. Cortical DWI hyperintensities were also common (64%). EEG showed diffuse or focal slow wave activity in 68% of patients, especially with visual hallucinations (85%). Neurological symptoms completely resolved in 78% of patients within 6 (IQR 3–10) days, following aggressive treatment and glucose normalization.ConclusionsOur results suggest neuronal dysfunction on a metabolic basis as the leading cause of acute neurological deficits in NKHHS. Despite the generally favorable prognosis, prompt identification and aggressive treatment are crucial to avoid irreversible damage. Larger cohort studies are needed to confirm our findings.
The role of airspeed variability in fixed-time, fuel-optimal aircraft trajectory planning
Authors: Wells Cathie A. , Kalise Dante , Nichols Nancy K. , Poll Ian , Williams Paul D. 
Published: April 2022

AbstractWith the advent of improved aircraft situational awareness and the need for airlines to reduce their fuel consumption and environmental impact whilst adhering to strict timetables, fixed-time, fuel-optimal routing is vital. Here, the aircraft trajectory planning problem is addressed using optimal control theory. Two variants of a finite horizon optimal control formulation for fuel burn minimization are developed, subject to arrival constraints, an aerodynamic fuel-burn model, and a data-driven wind field. In the first variant, the control variable is expressed as a set of position-dependent aircraft headings, with the optimal control problem solved through a reduced gradient approach at a range of fixed airspeeds. The fuel optimal result is taken as the lowest fuel use recorded. In the second variant, both heading angle and airspeed are controlled. Results from three months of simulated flight routes between London and New York show that permitting optimised en-route airspeed variations leads to fuel savings of 0.5% on an average day (and up to 4% on certain days), compared with fixed airspeed flights. We conclude that significant fuel savings are possible if airspeeds are allowed to vary en route to take optimal advantage of the wind field.
In Vitro ADME and Preclinical Pharmacokinetics of Ulotaront, a TAAR1/5-HT1A Receptor Agonist for the Treatment of Schizophrenia
Authors: Xiao Guangqing , Chen Yu-Luan , Dedic Nina , Xie Linghong , Koblan Kenneth S. , Galluppi Gerald R. 
Published: April 2022

Abstract
Purpose
Ulotaront (SEP-363856) is a TAAR1 agonist with 5-HT1A agonist activity currently in clinical development for the treatment of schizophrenia. The objectives of the current study were to characterize the in vitro ADME properties, preclinical PK, and to evaluate the DDI potential of ulotaront and its major metabolite SEP-383103.

Methods
Solubility, permeability, plasma protein binding, CYP inhibition and induction, transporter inhibition and uptake studies were conducted in vitro. Phenotyping studies were conducted using recombinant human CYPs and FMOs, human liver microsomes and human liver homogenates. Preclinical plasma and brain pharmacokinetics were determined after a single intraperitoneal, intravenous, and oral administration of ulotaront.

Results
Ulotaront is a compound of high solubility, high permeability, and low binding to plasma proteins. Ulotaront metabolism is mediated via both NADPH-dependent and NADPH-independent pathways, with CYP2D6 as the major metabolizing enzyme. Ulotaront is an inducer of CYP2B6, and an inhibitor of CYP2D6, OCT1 and OCT2, while SEP-383103 is neither a CYP inducer nor a potent inhibitor of CYPs and human transporters. Ulotaront exhibits rapid absorption, greater than 70% bioavailability, approximately 3.5 L/kg volume of distribution, 1.5-4 h half-life, 12-43 ml/min/kg clearance, and good penetration across the blood–brain barrier in preclinical species.

Conclusions
Ulotaront has been designated as a BCS1 compound by US FDA. The ability of ulotaront to penetrate the blood–brain barrier for CNS targeting has been demonstrated in mice and rats. The potential for ulotaront and SEP-383103 to act as perpetrators of CYP and transporter-mediated DDIs is predicted to be remote.
Supporting professional development for educators during the pandemic: Lessons from an international blended learning diploma program
Authors: Jen Enyi , Mathijssen Sven , Hoogeveen Lianne 
Published: April 2022

AbstractThis article discusses issues that emerged from conducting professional development activities for educators during the Covid-19 pandemic. In 2020, as post-academic educational trainers, the authors worked closely with more than 200 professional educators who participated in an international diploma program to develop their professional skills and gain positive and insightful experience. Here, they share three lessons they learned while working with professional educators: (a) teachers face new challenges in the use of educational technology, (b) teachers wonder how to motivate learners with diverse abilities in a virtual setting, and (c) building a supportive community is essential. Suggestions and recommendations are also provided.
Stochastic dynamic simulation of railway vehicles collision using data-driven modelling approach
Authors: Dong Shaodi , Tang Zhao , Wu Michelle , Zhang Jianjun 
Published: April 2022

AbstractUsing stochastic dynamic simulation for railway vehicle collision still faces many challenges, such as high modelling complexity and time-consuming. To address the challenges, we introduce a novel data-driven stochastic process modelling (DSPM) approach into dynamic simulation of the railway vehicle collision. This DSPM approach consists of two steps: (i) process description, four kinds of kernels are used to describe the uncertainty inherent in collision processes; (ii) solving, stochastic variational inferences and mini-batch algorithms can then be used to accelerate computations of stochastic processes. By applying DSPM, Gaussian process regression (GPR) and finite element (FE) methods to two collision scenarios (i.e. lead car colliding with a rigid wall, and the lead car colliding with another lead car), we are able to achieve a comprehensive analysis. The comparison between the DSPM approach and the FE method revealed that the DSPM approach is capable of calculating the corresponding confidence interval, simultaneously improving the overall computational efficiency. Comparing the DSPM approach with the GPR method indicates that the DSPM approach has the ability to accurately describe the dynamic response under unknown conditions. Overall, this research demonstrates the feasibility and usability of the proposed DSPM approach for stochastic dynamics simulation of the railway vehicle collision.
Role of Climate Change in Changing Hepatic Health Maps
Authors: Saad-Hussein Amal , Ramadan Haidi Karam-Allah , Bareedy Ashraf , Elwakil Reda 
Published: April 2022

Abstract

Purpose of Review

Climate change (CC) is currently responsible for global weather extremes. These weather extremes could contribute to changes in the pattern of health problems. The purpose of this review is to discuss the role of CC on remapping of hepatic diseases and the mechanisms of re-mapping.

Recent Findings

CC was found to have a major influence on the distribution and severity of hepatic diseases, such as outbreaks of vector-borne, water or food-borne, parasitic diseases, re-emerging of disappeared diseases, or emerging of new forms of infectious agents. Migration of infected people from endemic areas due to the CC disasters results in rapid dissemination of infectious diseases that leads to outbreaks or endemicity of diseases in new areas. CC could cause increasing chemical emissions, or change in its biodegradability, or restriction in its dispersion, such as PM, PAHs, heavy metals, mycotoxins, and aquatic toxins. Increase in the concentrations of these chemicals may have significant impacts in changing the health map of hepatic toxicity and liver cancer.

Summary

The current review confirms the role of CC in changing the pattern of several liver health problems and remapping of these problems in several regions of the world. This review could be of high importance to the health decision-makers as an early alarm and prediction of hepatic health problems with the projected CC.