bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional Anaesthesia for Hip Surgeries
Authors: Šakić Livija , Šakić Kata , Šakić Šime 
Published: November 2022

Regional anaesthesia is essential for hip arthroplasty programmes and depends on anaesthesiologist’s experienced choice. Good analgesia and the avoidance of post-operative nausea and vomiting are prerequisites for early ambulation and patient compliance with post-operative protocols. Regional anaesthesia, both neuraxial and peripheral nerve blocks, is superior to systemic opioid analgesia at all-time points in the first 3 days following surgery and by avoiding opioids, the risks and incidence of opioid analgesia are removed. Safety of drugs for intrathecal injections and complications from spinal anaesthesia continue to be examined and re-examined in order to improve safety of the technique. Prevention of post-operative cognitive dysfunction and early mobilisation is a key part of the management of patients with hip fractures.
Hunters' Palette
Authors: Smolik Joe 
Published: November 2022

This paper proposes that the enigmatic double bull on the Hunters’ Palette, now at the British Museum and the Louvre, represents a rare type of mutant bovine, a conjoined twin of type ischiopagus. Although the incidence of this biological anomaly in cattle is low, it is likely that such creatures were observed from time to time in the Nile Valley. The case for a mutant bull is supported by pictures of modern ischiopagi, veterinary references, Nubian petroglyphs, and hieroglyphic signs. The portrayal of a mutant animal on predynastic palettes is not unprecedented.
Capart and Fischer suggested that the double bull was an early hieroglyph, but neither explained how or why it became a determinative in verbs meaning “to move back and forth.” It is possible that it was inspired by the back and forth grazing movement of a real double bull. The proposal would seem consistent with Frankfort’s observation about the profound influence of cattle on the ancient Egyptian language. The double bull hypothesis may also elucidate the puzzling association of such a creature with a canal in the Third Upper Nome of Egypt.
Other objects representing the double bull—amulets, seals, a macehead, etc.—are attested intermittently from the Predynastic to the Late Period when the amulet is rendered in the form of a “double Apis;” generally these objects have apotropaic connotations. Texts containing the double bull determinative exist more or less in parallel with the representational forms and maintain the same meaning throughout. The paper ends with a consideration of the Hunters’ Palette as an exhibit of military power.

تقترحهذهالمقالةأنالثورالمزدوجالغامضالموجودعلىلوحةالصيادين،الموجودالآنفيالمتحفالبريطانيومتحفاللوفر،يمثلنوًعانادًرا من الأبقار المتحورة، وهو توأم ملتصق من نوع ischiopagus. على الرغم من أن نسبة حدوث هذا الشذوذ البيولوجي في الماشية منخفضة، فمن المحتمل أن هذه المخلوقات قد لوحظت من وقت لآخر في وادي النيل. يتم دعم وجود حالة الثور المتحور من خلال صور ischiopagus
الحديث والمراجع البيطرية والنقوش النوبية والرموز الهيروغليفية. ان تصوير حيوان متحور على اللوحات ليس غير مسبوق. اقترح كابارت وفيشر أن الثور المزدوج كان رمزاً من الرموز الهيروغليفية المبكرة، لكن لم يوضح أي منهما كيف أو لماذا أصبح خلال فترة الأسرات يرمز إلى الفعل الذي يعني «التحرك ذهابًا وإيابًا». من الممكن أن تكون مستوحاة من حركة الرعي (ذهابًا وإيابًا) لثور مزدوج حقيقي. قديبدوالاقتراحمتسًقامعملاحظةفرانكفورتحولالتأثيرالعميقللماشيةعلىاللغةالمصريةالقديمة.ثالثًا،قدتوضحفرضيةالثورالمزدوج
الارتباط المحير لمثل هذا المخلوق بقناة في الإقليم الثالث بمصر العليا. توثق القطع الأخرى التي تمثل الثور المزدوج - التمائم، والأختام، ورأس الصولجان، وما إلى ذلك - بشكل متقطع من عصر ما قبل الأسرات
إلى العصر المتأخر عندما يتم تقديم التميمة على شكل «أبيس مزدوج». توجد النصوص التي تحتوي على رمز الثور المزدوج بشكل أو بآخر بالتوازي مع الأشكال التمثيلية وتحافظ على نفس المعنى طوال الوقت.
Regulatory mechanism of Scutellaria baicalensis Georgi on bone cancer pain based on network pharmacology and experimental verification
Authors: Wang Aitao , Guo Dongmei , Cheng Hongyu , Jiang Hui , Liu Xiaojuan , Tie Muer 
Published: November 2022

Context
Scutellaria baicalensis Georgi (SBG) may relieve bone cancer pain (BCP) by regulating cell proliferation, angiogenesis, and apoptosis.

Objective
The mechanism of SBG in the treatment of BCP remains to be further explored.

Methods
The active compounds and targets of SBG were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and SwissTargetPrediction databases. BCP-related targets were screened from NCBI and GeneCards databases. Additionally, Cytoscape software was applied to construct network diagrams, and OmicShare platform was used to enrich Gene Ontology (GO) and pathways. Finally, the verification of active compounds and core targets was performed based on quantitative real-time PCR (qRT-PCR).

Results
Interestingly, we identified baicalein and wogonin as the main active components of SBG. A total of 41 SBG targets, including VEGFA, IL6, MAPK3, JUN and TNF, were obtained in the treatment of BCP. In addition, pathways in cancer may be an essential way of SBG in the treatment of BCP. Experimental verification had shown that baicalein and wogonin were significantly related to BCP core targets.

Conclusions
The active components of SBG have been clarified, and the mechanism of the active components in treating BCP has been predicted and verified, which provides an experimental and theoretical basis for the in-depth elucidation of the pharmacodynamics material basis and mechanism of SBG.
Ribosome biogenesis‐based predictive biomarkers in endocrine therapy (Anastrozole) combined with mTOR inhibitor (Vistusertib) in endometrial cancer: translational study from the VICTORIA trial in collaboration with the GINECO group
Authors: Mourksi Nour‐El‐Houda , Dalban Cécile , Colombe‐Vermorel Amélie , Odeyer Laetitia , Simioni Valentin , Frenel Jean‐Sébastien , Fabbro Michel , Bazan Fernando , Abadie‐Lacourtoisie Sophie , Coquan Elodie , Martinez Séverine , Garin Gwenaelle , Tabone‐Eglinger Séverine , Treilleux Isabelle , Chabaud Sylvie , Pérol David , Ray‐Coquard Isabelle , Heudel Pierre‐Etienne , Diaz Jean‐Jacques , Marcel Virginie 
Published: November 2022

Resistance of advanced hormone‐dependent endometrial carcinoma to endocrine therapy remains a worldwide clinical issue. We recently reported that the combination of Vistusertib (V, mTOR inhibitor) and Anastrozole (A, aromatase inhibitor) improves the progression‐free rate compared to Anastrozole alone. However, a better patient selection based on biomarkers would improve patient outcome. We evaluate for the first time the usage of ribosome biogenesis (RiBi) factors as a source of innovative markers. Using 47 FFPE tumours (A n = 18; V + A n = 29), 32 blood samples (A n = 13; V + A n = 19) and 30 samples of total RNAs (A n = 12; V + A n = 18) from the VICTORIA clinical trial, we observed an association between RiBi‐associated markers and drug activity or prediction of treatment response. NOP10 and NHP2 mRNA levels were significantly higher in non‐responders compared to responders in the Vistusertib + Anastrozole arm (P = 0.0194 and P = 0.0002 respectively; i.e. 8 weeks progression‐free survival as endpoint). This study provides RiBi‐based markers relevant for a better selection of patients with advanced endometrial carcinoma by predicting the response of endocrine therapy combined with mTOR inhibitor.
Navigating the narrative: An eye‐tracking study of readers' strategies when Reading comic page layouts
Authors: Kirtley Clare , Murray Christopher , Vaughan Phillip B. , Tatler Benjamin W. 
Published: November 2022

AbstractIn multimedia stimuli (e.g., comics), the reader must follow a narrative in which text and image both contribute information, and artists may use more irregular layouts which must still be followed correctly. While previous work has found that the external structure (outlines) of panels is a major contributor to navigation decisions in comics, other studies have shown that panel content can affect reading order. The present studies use eye‐tracking to investigate these contributions further. In Experiment 1, the reading behaviors on six layout variations were compared. The influence of the external structure was replicated, but an effect of text location was also found for one layout type. Experiment 2 focused on variations of this particular layout, manipulating the location of text within critical panels. Panel content was a consistent effect for all variations. While most navigation decisions are made using the external structure, content becomes key when resolving ambiguous layouts.
A Molecularly Tailored Photosensitizer with an Efficiency of 13.2% for Dye‐Sensitized Solar Cells
Authors: Grobelny Anna , Shen Zhongjin , Eickemeyer Felix T. , Antariksa Naura F. , Zapotoczny Szczepan , Zakeeruddin Shaik M. , Grätzel Michael 
Published: November 2022

AbstractPhotosensitizers yielding superior photocurrents are crucial for copper‐electrolyte‐based highly efficient dye‐sensitized solar cells (DSCs). Herein, two molecularly tailored organic sensitizers are presented, coded ZS4 and ZS5, through judiciously employing dithieno[3,2‐b:2″,3″‐d]pyrrole (DTP) as the π‐linker and hexyloxy‐substituted diphenylquinoxaline (HPQ) or naphthalene‐fused‐quinoxaline (NFQ) as the auxiliary electron‐accepting unit, respectively. Endowed with the HPQ acceptor, ZS4 shows more efficient electron injection and charge collection based on substantially reduced interfacial charge recombination as compared to ZS5. As a result, ZS4‐based DSCs achieve a power conversion efficiency (PCE) of 13.2% under standard AM1.5G sunlight, with a high short‐circuit photocurrent density (Jsc) of 16.3 mA cm−2, an open‐circuit voltage (Voc) of 1.05 V and a fill factor (FF) of 77.1%. Remarkably, DSCs sensitized with ZS4 exhibit an outstanding stability, retaining 95% of their initial PCE under continuous light soaking for 1000 h. It is believed that this is a new record efficiency reported so far for copper‐electrolyte‐based DSCs using a single sensitizer. The work highlights the importance of developing molecularly tailored photosensitizers for highly efficient DSCs with copper electrolyte.
Ultrafast Spectroscopy of Plasmons and Free Carriers in 2D MXenes
Authors: Colin‐Ulloa Erika , Fitzgerald Andrew , Montazeri Kiana , Mann Javery , Natu Varun , Ngo Ken , Uzarski Joshua , Barsoum Michel W. , Titova Lyubov V. 
Published: November 2022

Abstract2D MXenes have diverse and chemically tunable optical properties that arise from an interplay between free carriers, interband transitions, and plasmon resonances. The nature of photoexcitations and their dynamics in three different members of the MXene family, Ti3C2, Mo2Ti2C3, and Nb2C, are investigated using two complementary pump‐probe techniques, transient optical absorption, and time‐resolved terahertz (THz) spectroscopy. Measurements reveal pronounced plasmonic effects in the visible and near‐IR in all three. Optical excitation, with either 400 or 800 nm pulses, results in a rapid increase in lattice temperature, evidenced by a pronounced broadening of the plasmon mode that presents as a plasmon bleach in transient absorption measurements. Observed kinetics of plasmon bleach recovery provide a means to monitor lattice cooling. Remarkably slow cooling, proceeding over hundreds of picoseconds to nanoseconds time scales, implies MXenes have low thermal conductivities. The slowest recovery kinetics are observed in the MXene with the highest free carrier density, viz. Ti3C2, that supports phonon scattering by free carriers as a possible mechanism limiting thermal conductivity. These new insights into photoexcitation dynamics can facilitate their applications in photothermal solar energy conversion, plasmonic devices, and even photothermal therapy and drug delivery.
Chemo‐ and Regioselective C−H Sulfidation of Indoles for the Synthesis of Tolylthioindoles under Metal‐Free Conditions
Authors: Zheng Nian , Shi Wei‐Yu , Ding Ya‐Nan , Liu Xue‐Yuan , Liang Yong‐Min 
Published: November 2022

AbstractControllable chemoselectivity and regioselectivity synthesis of 3‐sulfinylated, 3‐sulfenylated and 2‐sulfonylated indoles via direct C−H functionalization are realized under metal‐free conditions. In particular, the synthesis of 3‐arylsulfinylindoles in high yields from a sulfone substrate in water without additives is reported. The process displays excellent functional groups compatibility. p‐Toluenesulfonyl cyanide (TsCN) possesses a hexavalent sulfonyl group, as an odorless and easy‐to‐handle solid, which has been used as a new sulfur reagent through the cleavage of S−C and S=O bonds in our work.magnified image
Impact of simulated hail damage at different growth stages and canopy positions on rainfed and irrigated winter wheat
Authors: Holman Johnathon D. , Lollato Romulo P. , Zarnstorff Mark , Houx James , Assefa Yared 
Published: November 2022

AbstractProducers and crop insurance providers will benefit from an accurate assessment of yield reduction after hailstorms that considers crop management, weather, growth stage, and impacted part of crop (hail affected canopy position). But, limited information is available. The main objectives of this study were to quantify wheat (Triticum aestivum L.) yield losses associated with simulated hail damage timing and canopy position. The study was conducted in two locations (Garden City [irrigated], and Manhattan [rainfed]) in Kansas, from 2018 to 2020 and 2016 to 2018, respectively. Treatments were an incomplete factorial combination of stem bending at seven flowering stages, above or below the flag leaf and a nontreated control. Results of the study indicated 11%–22% wheat yield reduction due to simulated hail damage above the flag leaf and 32%–52% due to hail impact below the flag leaf under irrigated conditions. Within the high‐yielding rainfed environment, hail damage caused up to 20% yield reduction compared with the control. In rainfed and low‐yielding environments, the impact of hail damage was mainly dependent on the growth stage of wheat at hail occurrence. Hail damage at Feekes 11.2–11.4 stages decreased yield by 20%–50% from the rainfed control. Hail damage at Feekes 10.0–10.5.4 decreased yield by 50%–70% from the rainfed control. We provide empirical evidence that indicates hail damage on wheat is dependent on the interaction effect of in‐season crop water management, weather, canopy position and crop growth stage, and estimates of yield loss due to hail should consider these factors.
Two SOX11 variants cause Coffin–Siris syndrome with a new feature of sensorineural hearing loss
Authors: Wang Qiuquan , Wu Jie , Yang Jinyuan , Huang Shasha , Yuan Yongyi , Dai Pu 
Published: November 2022

AbstractCoffin‐Siris syndrome (CSS, OMIM#135900) is a rare congenital disorder associated with neurodevelopmental and dysmorphic features. The primary cause of CSS is pathogenic variants in any of 9 BAF chromatin‐remodeling complex encoding genes or the genes SOX11 and PHF6. Herein, we performed whole‐exome sequencing (WES) and a series of analyses of growth‐related, auditory, and radiological findings in two probands with syndromic sensorineural hearing loss and inner ear malformations who exhibited distinctive facial features, intellectual disability, growth retardation, and fifth finger malformation. Two de novo variants in the SOX11 gene (c.148A>C:p.Lys50Asn; c.811_814del:p.Asn271Serfs*10) were detected in these probands and were identified as pathogenic variants as per ACMG guidelines. These probands were diagnosed as having CSS based upon clinical and genetic findings. This is the first report of CSS caused by variants in SOX11 gene in Chinese individuals. Deleterious SOX11 variants can result in sensorineural hearing loss with inner ear malformation, potentially extending the array of phenotypes associated with these pathogenic variants. We suggest that both genetic and clinical findings be considered when diagnosing syndromic hearing loss.
Plasma and CSF biomarkers in a memory clinic: Head‐to‐head comparison of phosphorylated tau immunoassays
Authors: Ashton Nicholas J. , Puig‐Pijoan Albert , Milà‐Alomà Marta , Fernández‐Lebrero Aida , García‐Escobar Greta , González‐Ortiz Fernándo , Kac Przemysław R. , Brum Wagner S. , Benedet Andréa L. , Lantero‐Rodriguez Juan , Day Theresa A. , Vanbrabant Jeroen , Stoops Erik , Vanmechelen Eugeen , Triana‐Baltzer Gallen , Moughadam Setareh , Kolb Hartmuth , Ortiz‐Romero Paula , Karikari Thomas K. , Minguillon Carolina , Hernández Sánchez Juan José , Navalpotro‐Gómez Irene , Grau‐Rivera Oriol , María Manero Rosa , Puente‐Periz Víctor , de la Torre Rafael , Roquer Jaume , Dage Jeff L. , Zetterberg Henrik , Blennow Kaj , Suárez‐Calvet Marc 
Published: November 2022

AbstractIntroductionDirect comparisons of the main blood phosphorylated tau immunoassays in memory clinic populations are needed to understand possible differences.MethodsIn the BIODEGMAR study, 197 participants presenting with cognitive complaints were classified into an Alzheimer's disease (AD) or a non‐AD cerebrospinal fluid (CSF) profile group, according to their amyloid beta 42/ phosphorylated tau (Aβ42/p‐tau) ratio. We performed a head‐to‐head comparison of nine plasma and nine CSF tau immunoassays and determined their accuracy to discriminate abnormal CSF Aβ42/p‐tau ratio.ResultsAll studied plasma tau biomarkers were significantly higher in the AD CSF profile group compared to the non‐AD CSF profile group and significantly discriminated abnormal CSF Aβ42/p‐tau ratio. For plasma p‐tau biomarkers, the higher discrimination accuracy was shown by Janssen p‐tau217 (r = 0.76; area under the curve [AUC] = 0.96), ADx p‐tau181 (r = 0.73; AUC = 0.94), and Lilly p‐tau217 (r = 0.73; AUC = 0.94).DiscussionSeveral plasma p‐tau biomarkers can be used in a specialized memory clinic as a stand‐alone biomarker to detect biologically‐defined AD.Highlights
Patients with an Alzheimer's disease cerebrospinal fluid (AD CSF) profile have higher plasma phosphorylated tau (p‐tau) levels than the non‐AD CSF profile group.
All plasma p‐tau biomarkers significantly discriminate patients with an AD CSF profile from the non‐AD CSF profile group.
Janssen p‐tau217, ADx p‐tau181, and Lilly p‐tau217 in plasma show the highest accuracy to detect biologically defined AD.
Janssen p‐tau217, ADx p‐tau181, Lilly p‐tau217, Lilly p‐tau181, and UGot p‐tau231 in plasma show performances that are comparable to their CSF counterparts.
Quantification of atropine sulphate monohydrate and obidoxime dichloride in two‐chamber autoinjectors for accessing uniformity of dosage
Authors: Spreitzer Iva , Morawej Paniz , Wosolsobe Richard , Stinzl Rainer , Wackerlig Judith 
Published: November 2022

AbstractIn the treatment of organophosphate poisoning atropine sulphate monohydrate (AT) and obidoxime dichloride (OB) play a vital role. Currently, the Austrian Armed Forces use the DOUBLEPEN OA two‐chamber autoinjector (ChemProtect) to administer these two drugs. The autoinjector is a part of military standard equipment as a “Basic CBRN‐First Aid Kit” and contains OB and AT with a declared concentration of 220 mg/2 ml and 2 mg/2 ml, respectively. Especially in the two‐chamber autoinjectors, it is highly possible that not all the content of the antidote solution is administered when the autoinjector is triggered. The purpose of the study was to analyze one hundred DOUBLEPEN OA autoinjectors from two different production batches (1707068 and 1707067) for volume loss, drug content and uniformity of dosage unit. Uniformity of dosage units, assessed by the content uniformity method (Chapter 2.9.40 of the European Pharmacopeia), requires the calculation of an acceptable value to quantify the uniformity of the drug product. An acceptance value for the first 10 dosage units of 15.0% or below is considered acceptable. The loss of volume was calculated by determining the density and mass of the solution after triggering the autoinjector. A quantitative high‐performance liquid chromatography method has been developed and in‐house validated for the determination of the content of two drugs. According to International Council for Harmonisation guidelines, the analytical method was proven to be accurate and repeatable. The obtained results show that the average loss of volume after injection was 5%, and the average content of OB and AT for batch 1707068, was 216.5 and 1.9 mg, while for batch 1707067 it was 224.2 and 2.0 mg, respectively. Although the loss of volume and content were observed, the calculated acceptance value for both production batches met the requirements of uniformity of dosage unit by the European Pharmacopeia.
Harnessing the potential of online marketplaces in the Philippines: Insights from the National Information and Communications Technology Household Survey
Authors: Bayudan‐Dacuycuy Connie , Dacuycuy Lawrence B. 
Published: November 2022

AbstractUsing the Philippinesʼ first nationally representative survey designed to characterise digital commercial and non‐commercial engagements, including the use of information and communications technology (ICT), the digital economy, and technology‐enabled activities, we investigate the presence of gendered disparities in online marketplaces. This is consistent with the spirit of a gender and development approach that aims for equitable outcomes between men and women. We verify whether the observed participation of women in online marketplaces results in higher online sales. To establish the determinants of participation in and incomes from online marketplaces, we use a Heckman estimator in cognisance of the non‐random choices people make when they enter online marketplaces. The negative selection indicates that those likely to sell have unobserved attributes negatively correlated with online income. Based on our modelʼs income predictions, men outperform women in online sales and hold the advantage, replicating a trend observed in traditional marketplaces. Results also highlight the importance of skills, digital awareness and habits, selling platforms, and ICT infrastructure. The paper also identifies potential initiatives for online marketplaces.
Franz Baron Nopcsa: A short life of research in dinosaur evolutionary paleobiology and Albanology
Authors: Weishampel David B. 
Published: November 2022

AbstractThe short life of Hungarian paleontologist and Albanologist, Franz Baron Nopcsa (1877–1933) is reviewed with an eye on his discoveries of the dinosaurs of Transylvania and their dwarfed nature, as well as his interest in the people of Albania, especially their social organization, laws, history, and ethnography during the first and second Balkan Wars. He also engaged in espionage in Romania during World War I. In addition to his research on the dwarfed dinosaurs and their insular context, his paleontological work also focused on neo‐Lamarckian evolutionary theory, the origin of avian flight, and growth and sexual dimorphism in dinosaurs based on osteology and bone microstructure.