bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary fat in relation to all‐cause mortality and cancer progression and death among people with metastatic colorectal cancer: Data fromCALGB80405 (Alliance)/SWOG80405
Authors: Van Blarigan Erin L. , Ma Chao , Ou Fang‐Shu , Bainter Tiffany M. , Venook Alan P. , Ng Kimmie , Niedzwiecki Donna , Giovannucci Edward , Lenz Heinz‐Josef , Polite Blase N. , Hochster Howard S. , Goldberg Richard M. , Mayer Robert J. , Blanke Charles D. , O'Reilly Eileen M. , Ciombor Kristen K. , Meyerhardt Jeffrey A. 
Published: July 2022

AbstractData on diet and survival among people with metastatic colorectal cancer are limited. We examined dietary fat in relation to all‐cause mortality and cancer progression or death among 1149 people in the Cancer and Leukemia Group B (Alliance)/Southwest Oncology Group (SWOG) 80405 trial who completed a food frequency questionnaire at initiation of treatment for advanced or metastatic colorectal cancer. We examined saturated, monounsaturated, total and specific types (n‐3, long‐chain n‐3 and n‐6) of polyunsaturated fat, animal and vegetable fats. We hypothesized higher vegetable fat intake would be associated with lower risk of all‐cause mortality and cancer progression. We used Cox proportional hazards regression to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI). Over median follow‐up of 6.1 years (interquartile range [IQR]: 5.3, 7.2 y), we observed 974 deaths and 1077 events of progression or death. Participants had a median age of 59 y; 41% were female and 86% identified as White. Moderate or higher vegetable fat was associated with lower risk of mortality and cancer progression or death (HRs comparing second, third and fourth to first quartile for all‐cause mortality: 0.74 [0.62, 0.90]; 0.75 [0.61, 0.91]; 0.79 [0.63, 1.00];Ptrend: .12; for cancer progression or death: 0.74 [0.62, 0.89]; 0.78 [0.64, 0.95]; 0.71 [0.57, 0.88];Ptrend: .01). No other fat type was associated with all‐cause mortality and cancer progression or death. Moderate or higher vegetable fat intake may be associated with lower risk of cancer progression or death among people with metastatic colorectal cancer.
A comparative study of flow cytometry‐sorted communities and shotgun viral metagenomics in a Singapore municipal wastewater treatment plant
Authors: Gu Xiaoqiong , Yang Yi , Mao Feijian , Lee Wei Lin , Armas Federica , You Fang , Needham David M. , Ng Charmaine , Chen Hongjie , Chandra Franciscus , Gin Karina Yew‐Hoong 
Published: July 2022

AbstractTraditional or “bulk” viral enrichment and amplification methods used in viral metagenomics introduce unavoidable bias in viral diversity. This bias is due to shortcomings in existing viral enrichment methods and overshadowing by the more abundant viral populations. To reduce the complexity and improve the resolution of viral diversity, we developed a strategy coupling fluorescence‐activated cell sorting (FACS) with random amplification and compared this to bulk metagenomics. This strategy was validated on both influent and effluent samples from a municipal wastewater treatment plant using the Modified Ludzack–Ettinger (MLE) process as the treatment method. We found that DNA and RNA communities generated using bulk samples were mostly different from those derived following FACS for both treatments before and after MLE. Before MLE treatment, FACS identified five viral families and 512 viral annotated contigs. Up to 43% of mapped reads were not detected in bulk samples. Nucleo‐cytoplasmic large DNA viral families were enriched to a greater extent in the FACS‐coupled subpopulations compared with bulk samples. FACS‐coupled viromes captured a single‐contig viral genome associated with Anabaena phage, which was not observed in bulk samples or in FACS‐sorted samples after MLE. These short metagenomic reads, which were assembled into a high‐quality draft genome of 46 kbp, were found to be highly dominant in one of the pre‐MLE FACS annotated virome fractions (57.4%). Using bulk metagenomics, we identified that between Primary Settling Tank and Secondary Settling Tank viromes, Virgaviridae, Astroviridae, Parvoviridae, Picobirnaviridae, Nodaviridae, and Iridoviridae were susceptible to MLE treatment. In all, bulk and FACS‐coupled metagenomics are complementary approaches that enable a more thorough understanding of the community structure of DNA and RNA viruses in complex environmental samples, of which the latter is critical for increasing the sensitivity of detection of viral signatures that would otherwise be lost through bulk viral metagenomics.
On flag‐transitive 2‐(k2,k,λ) $({k}^{2},k,\lambda )$ designs with λ∣k $\lambda | k$
Authors: Montinaro Alessandro , Francot Eliana 
Published: July 2022

AbstractIt is shown that, apart from the smallest Ree group, a flag‐transitive automorphism group of a 2‐ design , with , is either an affine group or an almost simple classical group. Moreover, when is the smallest Ree group, is isomorphic either to the 2‐ design or to one of the three 2‐ designs constructed in this paper. All the four 2‐designs have the 36 secants of a non‐degenerate conic of as a point set and 6‐sets of secants in a remarkable configuration as a block set.
Autophagy blockade potentiates cancer‐associated immunosuppression through programmed death ligand‐1 upregulation in bladder cancer
Authors: Tsai Te‐Fu , Chang An‐Chen , Chen Po‐Chun , Ho Chao‐Yen , Chen Hung‐En , Chou Kuang‐Yu , Hwang Thomas I‐Sheng 
Published: July 2022

AbstractA high basal level of autophagic flux in bladder cancer (BC) cells prevents cell death and weakens chemotherapy efficacy. However, how autophagy influences cancer‐associated immunosuppression in BC remains undetermined. In this study, we observed a negative correlation between the autophagy‐related markers LC3‐II and programmed death ligand‐1 (PD‐L1) in BC cells. The autophagy inhibitors chloroquine (CQ) and bafilomycin A1 (Baf‐A1) increased PD‐L1 expression in BC cells through the ERK–JNK–c‐Jun signal‐transduction pathway. Moreover, the treatment of BC cells with CQ and Baf‐A1 inhibited hsa‐microRNA‐34a (miR‐34a) expression and miR‐34a overexpression in BC cells prevented the autophagy blockade–induced PD‐L1 expression; a negative correlation between miR‐34a and PD‐L1 expression was observed during treatment with autophagy inhibitors. Furthermore, miR‐34a overexpression induced the cytotoxic activity of natural killer cells against BC cells. Our results provide evidence that autophagy blockade and its regulatory pathway affect cancer‐associated immunosuppression through PD‐L1 elevation. Thus, the coadministration of autophagy inhibitors and a PD‐L1 immune checkpoint blockade provides a potential therapeutic approach for treating BC.
I share, therefore I know? Sharing online content ‐ even without reading it ‐ inflates subjective knowledge
Authors: Ward Adrian F. , Zheng Jianqing (Frank) , Broniarczyk Susan M. 
Published: July 2022

AbstractBillions of people across the globe use social media to acquire and share information. A large and growing body of research examines how consuming online content affects what people know. The present research investigates a complementary, yet previously unstudied question: how might sharing online content affect what people think they know? Sharing signals expertise, and people frequently internalize their public behavior into their private self‐concepts. We therefore posit that sharing information on social media may cause people to believe they are as knowledgeable as their posts make them appear. We examine this possibility in the context of “sharing without reading,” a phenomenon that allows us to isolate the effect of sharing on subjective knowledge from any influence of reading or objective knowledge. Six studies provide correlational (study 1) and causal (studies 2, 2a) evidence that sharing—even without reading—increases subjective knowledge, and test the internalization mechanism by varying the degree to which sharing publicly commits the sharer to an expert identity (studies 3–5). A seventh study investigates potential consequences of sharing‐inflated subjective knowledge on downstream behavior in the domain of financial decision‐making.
Effect of supragingival plaque control on recurrent periodontitis and clinical stability among individuals under periodontal maintenance therapy: 10‐year follow‐up
Authors: Costa Fernando Oliveira , Costa Adriana Moreira , Cortelli José Roberto , Cortelli Sheila Cavalca , Costa Amanda Almeida , Lima Rafael Paschoal Esteves , Pereira Gustavo Henrique Mattos , Oliveira Alcione Maria Soares Dutra , Oliveira Peterson Antônio Dutra , Cota Luís Otávio Miranda 
Published: July 2022

AbstractBackgroundThe aim of this study was to evaluate the effect of supragingival plaque control on the recurrence of periodontitis (RP) and the achievement of a stable periodontal clinical endpoint after 10 years of periodontal maintenance therapy (PMT).MethodsThe present retrospective cohort study included 225 individuals in continuous PMT. The plaque index (PI) determining the oral hygiene (OH) status, periodontal clinical parameters, and other variables of interest were collected at three time points: T1 (prior to active periodontal therapy [APT]), T2 (after APT), and T3 (10 years after T2). According to PI records at T3, participants were categorized into: (1) good OH (GOH; PI ≤ 30%, n = 63); (2) fair OH (FOH; PI > 30% and ≤40%, n = 73); and (3) poor OH (POH; PI > 40%, n = 88). Data were analyzed using the chi‐square and Student t tests, analysis of variance (ANOVA), and mediation and regression analyses.ResultsSignificant differences in all periodontal clinical parameters between the GOH, FOH, and POH groups were observed at T3. The POH group exhibited higher mean bleeding on probing (BOP), periodontal probing depth (PD), and clinical attachment level (CAL), as well as higher tooth loss (POH > FOH > GOH; P < .001). There was an increased risk for RP in the FOH (odds ratio [OR] 2.02; CI, 1.10‐4.38) and POH (OR 4.33; CI, 2.17‐8.65) groups. Moreover, the FOH and POH groups had an approximately 2.5 and 6.0 times greater chance of not achieving a stable periodontal clinical endpoint, respectively.ConclusionsAfter 10 years of monitoring in PMT, individuals with higher PI scores (>30%) presented an unhealthier periodontal status, a higher risk for RP, and a lower chance of achieving ≤4 sites with PD ≥ 5 mm.
Grazing exclusion altered the pattern of the soil seed bank but not the aboveground vegetation along an altitudinal gradient in alpine grassland
Authors: Huang Mei , Sang Chao , Zhao Jingxue , Degen A. Allan , Chen Xiaopeng , Zhang Tao , Bai Yanfu , Li Shanshan , Wang Wenyin , Shrestha Nawal , Shang Zhanhuan 
Published: July 2022

AbstractGrazing exclusion by fencing is the principal option to restore degraded grassland, but its effects on recovery and succession of vegetation are not clear, especially in high mountain areas. In this study, we aimed to fill this gap by assessing the effect of seven‐year grazing exclusion on vegetation and soil seed bank along an altitudinal gradient in northern Tibet, China. Species richness, Shannon‐Wiener index and Simpson's diversity index of vegetation and soil seed bank, seed density, and the Sørensen index all displayed a mid‐domain (hump‐shaped) pattern with increasing altitude, except for the Shannon‐Wiener and Pielou indices of soil seed bank in fenced grasslands. These results demonstrated that the impact of grazing exclusion on the patterns of vegetation and soil seed bank change with altitude but are not synchronous. Grazing exclusion increased vegetation coverage but decreased soil seed bank density, and species diversity of vegetation and soil seed bank. The Sørensen index (0.03–0.2) and non‐metric multidimensional scaling (NMDS) analysis indicated that the species composition differed between vegetation and soil seed bank, but no difference was found between fenced and grazed grasslands. The low similarity suggests that the soil seed bank contributes little to vegetation recovery in alpine grassland. Seven‐year grazing exclusion had no effect on either vegetation succession or species composition of soil seed bank in alpine grassland. Overall, our findings suggest reconsidering the use of long‐term grazing exclusion to restore degraded grassland at high altitudes (above 4400 m above sea level) on the Tibetan Plateau.
Enhancing corrosion resistance of magnesium alloy by rGO/Mg(OH)2 composite coating
Authors: Yuan Jing , Cui Xiaofeng , Yuan Rui , Li Qiushi , Zheng Xuerong 
Published: July 2022

AbstractrGO/Mg(OH)2 composite films were fabricated on AZ61 alloy by the hydrothermal method in alkaline solutions containing deionized water and graphene oxide (GO). During the hydrothermal reaction, the Mg(OH)2 nanosheets and GO plates grew freely on the AZ61 substrate without any special orientation, and the GO was simultaneously reduced to rGO. With the increase of GO content in the hydrothermal solution, the corrosion resistance of the prepared composite films showed a trend of increasing first and then decreasing. When the content of GO incorporated in the hydrothermal solution is 5 mg, the corrosion current density (icorr) of the composite coating is reduced to the minimum (4.9 μA/cm2), which is seven times lower than that of the substrate and 3.5 times lower than that of the Mg(OH)2 monolayer. Based on experimental and molecular dynamics simulation results, the enhancement mechanism of the composite film was proposed, which is related to the growth of Mg(OH)2 layer, the “tortuous path” effect of GO and the slowing of chloride ion diffusion by GO functional groups.
Aqueous Supramolecular Co‐Assembly of Anionic and Cationic Photoresponsive Stiff‐Stilbene Amphiphiles
Authors: Kwan Khloe Shuk‐Ying , Lui Ying‐Ying , Kajitani Takashi , Leung Franco King‐Chi 
Published: July 2022

AbstractFabrication of macroscopic soft functional materials, such as macroscopic photoresponsive soft materials and artificial muscles, can be commonly prepared by charge screening of supramolecular assemblies with inorganic salt solutions using a shear‐flow method. However, some of the charged end‐groups of photoresponsive molecular amphiphiles cannot be stabilized with inorganic salt solutions to fabricate macroscopic soft materials. Stiff stilbene amphiphiles (SAs) functionalized with anionic phosphite and cationic quaternary ammonium end groups are designed and synthesized and their photochemical and supramolecular assembly properties are determined. Supramolecular co‐assembly of anionic and cationic nanotubes of SAs allows to transform into nanoribbons, confirmed by transmission electron microscopy, critical aggregation concentration, and Zeta potential measurements. Nanoribbons of anionic and cationic SAs can be prepared into macroscopic soft materials with inorganic salt solutions and surprisingly also with deionized water. The macroscopic soft material of anionic and cationic SAs can be stabilized at low concentration ≈5 mm. Meanwhile, the photoresponsiveness of the macroscopic soft materials is retained to provide macroscopic morphological change upon photoirradiation. These results exhibit the feasibility in fabrication of macroscopic functional soft materials from supramolecular assembly across multiple length‐scale without help of inorganic salts and offer ample opportunity in developing future soft supramolecular robotic systems.
Longitudinal comparison of the self‐entry Amyotrophic Lateral Sclerosis Functional Rating Scale‐Revised (ALSFRS‐RSE) and Rasch‐Built Overall Amyotrophic Lateral Sclerosis Disability Scale (ROADS) as outcome measures in people with amyotrophic lateral sclerosis
Authors: Johnson Stephen A. , Burke Katherine M. , Scheier Zoe A. , Keegan Mackenzie A. , Clark Alison P. , Chan James , Fournier Christina N. , Berry James D. 
Published: July 2022

AbstractIntroduction/aimsImproved functional outcome measures in amyotrophic lateral sclerosis (ALS) would aid ALS trial design and help hasten drug discovery. We evaluate the longitudinal performance of the Rasch‐Built Overall Amyotrophic Lateral Sclerosis Disability Scale (ROADS) compared to the Amyotrophic Lateral Sclerosis Functional Rating Scale Revised for Self‐Entry (ALSFRS‐RSE) as patient reported outcomes of functional status in people with ALS.MethodsParticipants completed the ROADS and the ALSFRS‐RSE questionnaires at baseline, 3‐, 6‐, and 12‐ mo using Research Electronic Data Capture as part of a prospective, longitudinal, remote, online survey study of fatigue in ALS from 9/2020 to 12/2021. The scales were compared cross‐sectionally (at baseline) and longitudinally. Correlation coefficients, coefficients of variation, and descriptive statistics were assessed.ResultsA total of 182 adults with ALS consented to the study. This volunteer sample was comprised of predominantly White, non‐Hispanic, non‐smoking participants. Consented participant survey completion was approximately 90% at baseline and greater than 40% at 12 mo. The ALSFRS‐RSE and the ROADS had high, significant agreement at 3 and 6 mo by Cohen's kappa ≥71% (p < 0.001); the number of functional increases or plateaus on the two scales were not significantly different; and the coefficient of variation of functional decline was similar at the 6‐month mark, though higher for the ROADS at 3 mo and lower at 12 mo.DiscussionAlthough the ROADS performed similarly to the ALSFRS‐RSE in an observational cohort, it has psychometric advantages, such as Rasch‐modeling and unidimensionality. It merits further investigation as a patient reported outcome of overall disability and efficacy outcome measure in ALS trials.
Adaptive finite time fault tolerant control for the quadrotor unmanned aerial vehicles based on time‐triggered strategy
Authors: Di Wangyue , Li Zhigang , Lv Dongyi , Gao Chuang , Yang Yonghui , Zhou Xin 
Published: July 2022

AbstractThis article investigates the adaptive finite time tracking control problem for quadrotor unmanned aerial vehicles (QUAV) subject to actuator failure with event‐triggered control strategy. It is assumed that the models of actuator failure are actuator blockage and saturation faults. The finite time performance function and adaptive backstepping method are combined to design the controller to compensate the influence of actuator failure, so as to ensure that the tracking error converges to the preset neighborhood near the origin in finite time. In addition, a new event‐triggered strategy is introduced to save communication resources and avoid the Zeno‐behavior, which defines the variable threshold as a function combining with tracking error and positive constants. The variable threshold not only effectively reduces triggering times, but also makes the design of the controller more flexible. It is proved that the closed‐loop system is stability. Finally, the effectiveness of this method is verified by simulation.
Stability of resilience in times of the COVID‐19 pandemic
Authors: Köhne Sophie , Engert Veronika , Rosendahl Jenny 
Published: July 2022

AbstractThere is disagreement among researchers regarding the conceptualization of resilience as a dynamic state or stable trait. Aiming to shed light on the state‐versus‐trait debate, we explored the stability and construct validity of four of the most frequently utilized state or trait resilience scales in a longitudinal assessment. Additionally, we examined the predictive validity of these scales. Our study was conducted before and during the COVID‐19 pandemic, which served as collectively experienced adversity. Correlations among the resilience scales and among resilience scales and Big Five personality traits were strong. All except one scale showed high test–retest correlations. Experience of an additional critical life event during the pandemic led to an increase in resilience. Other than in cross‐sectional studies, associations between resilience and psychological distress were weak, because personality and baseline psychological distress were controlled for. Nevertheless, next to personality, resilience explained additional variance in distress change. Our results show relatively high stability of resilience overall. Yet, they also confirm dynamic resilience features, suggesting that resilience change occurs with significant adversity, leading to improved adaptation. To gauge the true association between resilience and mental health, baseline levels of these variables as well as personality traits should be considered.
A proteome‐scale analysis of vertebrate protein amino acid occurrence: Thermoadaptation shows a correlation with protein solvation but less so with dynamics
Authors: Li Zhen‐Lu , Buck Matthias 
Published: July 2022

AbstractDespite differences in behaviors and living conditions, vertebrate organisms share the great majority of proteins, often with subtle differences in amino acid sequence. Here, we present a simple way to analyze the difference in amino acid occurrence by comparing highly homologous proteins on a subproteome level between several vertebrate model organisms. Specifically, we use this method to identify a pattern of amino acid conservation as well as a shift in amino acid occurrence between homeotherms (warm‐blooded species) and poikilotherms (cold‐blooded species). Importantly, this general analysis and a specific example further establish a broad correlation, if not likely connection between the thermal adaptation of protein sequences and two of their physical features: on average a change in their protein dynamics and, even more strongly, in their solvation. For poikilotherms, such as frog and fish, the lower body temperature is expected to increase the protein–protein interaction due to a decrease in protein internal dynamics. In order to counteract the tendency for enhanced binding caused by low temperatures, poikilotherms enhance the solvation of their proteins by favoring polar amino acids. This feature appears to dominate over possible changes in dynamics for some proteins. The results suggest that a general trend for amino acid choice is part of the mechanism for thermoadaptation of vertebrate organisms at the molecular level.
Challenging glyphosate resistanceEPSPSP106SandTIPSmutations with soybean competition and glyphosate: implications for management
Authors: Barroso Arthur Arrobas Martins , Michelon Thomas Bruno , da Costa Aguiar Alves Pedro Luis , Han Heping , Yu Qin , Powles Stephen B. , Vila‐Aiub Martin M. 
Published: July 2022

AbstractBACKGROUNDEleusine indica(L.) Gaertn. (goosegrass) is a major weed in global cropping systems. It has evolved resistance to glyphosate due to single Pro‐106‐Ser (P106S) or double Thr‐102‐Ile + Pro‐106‐Ser (TIPS)EPSPStarget site mutations. Here, experiments were conducted to evaluate the single effect of soybean competition and its combined effect with a glyphosate field dose (1080 g ae ha−1) on the growth and fitness of plants carrying these glyphosate resistance endowing target site mutations.RESULTSTIPSE. indicaplants are highly glyphosate‐resistant but the double mutation endows a substantial fitness cost. The TIPS fitness penalty increased under the effect of soybean competition resulting in a cost of 95%, 95% and 96% in terms of, respectively, vegetative growth, seed mass and seed number investment. Glyphosate treatment of these glyphosate‐resistant TIPS plants showed an increase in growth relative to those without glyphosate. Conversely, for the P106S moderate glyphosate resistance mutation, glyphosate treatment alone reduced survival rate, vegetative growth, aboveground biomass (34%), seed mass (48%) and number (52%) of P106S plants relative to the glyphosate nontreated plants. However, under the combined effects of both soybean competition and the field‐recommended glyphosate dose, vegetative growth, aboveground biomass, seed mass and number of P106S and TIPS plants were substantially limited (by ≤99%).CONCLUSIONThe ecological environment imposed by intense competition from a soybean crop sets a significant constraint for the landscape‐level increase of both theE. indicasingle and double glyphosate resistance mutations in the agroecosystem and highlights the key role of crop competition in limiting the population growth of weeds, whether they are herbicide‐resistant or susceptible. © 2022 Society of Chemical Industry.