bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conceptualization of the latent structure of autism: further evidence and discussion of dimensional and hybrid models
Authors: Wittkopf Sarah , Langmann Anika , Roessner Veit , Roepke Stefan , Poustka Luise , Nenadić Igor , Stroth Sanna , Kamp-Becker Inge 
Published: August 2022

AbstractAutism spectrum disorder (ASD) might be conceptualized as an essentially dimensional, categorical, or hybrid model. Yet, current empirical studies are inconclusive and the latent structure of ASD has explicitly been examined only in a few studies. The aim of our study was to identify and discuss the latent model structure of behavioral symptoms related to ASD and to address the question of whether categories and/or dimensions best represent ASD symptoms. We included data of 2920 participants (1–72 years of age), evaluated with the Autism Diagnostic Observation Schedule (Modules 1–4). We applied latent class analysis, confirmatory factor analysis, and factor mixture modeling and evaluated the model fit by a combination of criteria. Based on the model selection criteria, the model fits, the interpretability as well as the clinical utility we conclude that the hybrid model serves best for conceptualization and assessment of ASD symptoms. It is both grounded in empirical evidence and in clinical usefulness, is in line with the current classification system (DSM-5) and has the potential of being more specific than the dimensional approach (decreasing false positive diagnoses).
The Importance of Electrostatics and Polarization for Noncovalent Interactions: Ionic Hydrogen Bonds vs Ionic Halogen Bonds
Authors: Brinck Tore , Borrfors André Nyberg 
Published: August 2022

AbstractA series of 26 hydrogen-bonded complexes between Br− and halogen, oxygen and sulfur hydrogen-bond (HB) donors is investigated at the M06-2X/6–311 + G(2df,2p) level of theory. Analysis using a model in which Br− is replaced by a point charge shows that the interaction energy ($${\Delta E}_{Int}$$

Δ
E

Int

) of the complexes is accurately reproduced by the scaled interaction energy with the point charge ($${\Delta E}_{Int}^{PC}$$

Δ
E

Int

PC

).This is demonstrated by $${\Delta E}_{Int}=0.86{\Delta E}_{Int}^{PC}$$

Δ
E

Int

=
0.86

Δ
E

Int

PC

with a correlation coefficient, R2 =0.999. The only outlier is (Br-H-Br)−, which generally is classified as a strong charge-transfer complex with covalent character rather than a HB complex. $${\Delta E}_{Int}^{PC}$$

Δ
E

Int

PC

can be divided rigorously into an electrostatic contribution ($${\Delta E}_{ES}^{PC}$$

Δ
E

ES

PC

) and a polarization contribution ($${\Delta E}_{Pol}^{PC}$$

Δ
E

Pol

PC

).Within the set of HB complexes investigated, the former varies between -7.2 and -32.7 kcal mol−1, whereas the latter varies between -1.6 and -11.5 kcal mol−1. Compared to our previous study of halogen-bonded (XB) complexes between Br− and C–Br XB donors, the electrostatic contribution is generally stronger and the polarization contribution is generally weaker in the HB complexes. However, for both types of bonding, the variation in interaction strength can be reproduced accurately without invoking a charge-transfer term. For the Br−···HF complex, the importance of charge penetration on the variation of the interaction energy with intermolecular distance is investigated. It is shown that the repulsive character of $${\Delta E}_{Int}$$

Δ
E

Int

at short distances in this complex to a large extent can be attributed to charge penetration.
Development of a customizable interactions questionnaire (CIQ) for evaluating interactions with objects in augmented/virtual reality
Authors: Gao Meiyuzi , Boehm-Davis Deborah A. 
Published: August 2022

AbstractAs new methods for interacting with systems are being developed for use within augmented or virtual reality, their impact on the quality of the user’s experience needs to be assessed. Although many instruments exist for evaluating the overall user experience or the computer interface used to complete tasks, few provide measures that can be used to evaluate the specific forms of interaction typically used in these environments. This paper describes the development of a customizable questionnaire for measuring the subjective user experience that focuses on the quality of the interactions with objects in augmented reality/virtual reality (AR/VR) worlds, which we are calling the Customizable Interactions Questionnaire, or (CIQ). The final questionnaire measures five factors that are related to user satisfaction while using the system: quality of interactions, assessment of task performance, comfort, quality of sensory enhancements, and consistency with expectations.
Efficacy of desferrioxamine mesylate in intracerebral hematoma: a systemic review and meta-analysis
Authors: Zhao Kai , Li Jing , Zhang Qiang , Yang Mingfei 
Published: August 2022

Abstract
Background
Previous meta-analysis had concluded that desferrioxamine mesylate (DFO) could effectively treat intracerebral hematoma (ICH) in animal models. We hope to confirm that DFO could treat ICH patients effectively through the systemic review and meta-analysis of clinical researches.

Method
Data extraction included hematoma volume (HV), reduction of National Institute of Health Stroke Scale (NIHSS) scores, and relative perihematomal edema (RPHE). The standard mean difference (SMD) and 95% confidence interval (95%CI) were calculated by fixed effects model. I-square (I2) statistic was used to test the heterogeneity. All p values were two-side with a significant level at 0.05.

Results
Five randomized controlled trials were included in the meta-analysis, which included 239 patients. At 7 days after onset, there was significant difference of RPHE development (− 1.87 (− 2.22, − 1.51) (I2 = 0, p = 0.639)) and significant difference of HV absorption (− 0.71 (− 1.06, 0.36) (I2 = 17.5%, p = 0.271)) between DFO and control groups. There was significant difference of reduction of NHISS scores (0.25 (0.05, 0.46) (I2 = 0, p = 0.992)) between DFO and control groups at 30 days after onset.

Conclusion
DFO reduced HV and perihematomal edema in ICH patients at 7 days after onset and improve neurological function at 30 days after onset efficiently and safely. DFO might be a new route of improving treatment of ICH.
Exploring Factors Associated with Parent Engagement in A Parenting Program in Southeastern Europe
Authors: Williams Margiad E. , Foran Heather M. , Hutchings Judy , Frantz Inga , Taut Diana , Lachman Jamie M. , Ward Catherine L. , Heinrichs Nina 
Published: August 2022

AbstractParental engagement in parenting programs is essential for good outcomes but can be challenging for many families. In low- and middle-income countries, where resources are limited and there are fewer support services, there is little research examining the factors that influence engagement. This mixed-methods study explored factors associated with parent engagement, as well as barriers and supports, in a pilot evaluation of a parenting program with 140 parents in North Macedonia, Republic of Moldova, and Romania. The relationship between various quantitative types of engagement (e.g., premature drop-out, participation) and a range of demographic, personal, and implementation factors were examined. Qualitative parent interviews explored barriers and supports to program engagement. Implementation variables (e.g., phone calls with parents, program fidelity and text messages sent to parents) were consistently positively associated with different types of engagement after controlling for other factors. Parents of boys, being a victim of intimate partner violence, more children in the household and better parental well-being were positively associated with premature drop-out whilst having a child enrolled in school was positively associated with participation. Barriers included logistical factors such as timing and lack of childcare facilities. Factors that increased engagement included facilitator skills/support, weekly text messages and phone calls and engagement strategies such as transport and childcare. The results emphasise the importance of implementation factors in increasing parent engagement in parenting programs and will help to inform the next phase of the project as well as other family-support initiatives in the three countries. The trial is registered on ClinicalTrials.gov (ID: NCT03552250).
Dominance-based variable analysis for large-scale multi-objective problems
Authors: Irawan Dani , Naujoks Boris , Bäck Thomas , Emmerich Michael 
Published: August 2022

AbstractOptimization problems with multiple objectives and many input variables inherit challenges from both large-scale optimization and multi-objective optimization. To solve the problems, decomposition and transformation methods are frequently used. In this study, an improved control variable analysis is proposed based on dominance and diversity in Pareto optimization. Further, the decomposition method is used in a cooperative coevolution framework with orthogonal sampling mutation. The algorithm’s performances are compared against the weighted optimization framework. The results show that the proposed decomposition method has much better accuracy compared to the traditional method. The results also show that the cooperative coevolution framework with a good grouping is very competitive. Additionally, the number of search directions in orthogonal sampling can be easily configured. A small number of search directions will reduce the search space greatly while also restricting the area that can be explored and vice versa.
CD93 is Associated with Glioma-related Malignant Processes and Immunosuppressive Cell Infiltration as an Inspiring Biomarker of Survivance
Authors: Ma Kaiming , Chen Suhua , Chen Xin , Zhao Xiaofang , Yang Jun 
Published: August 2022

AbstractPrevious reports have confirmed the significance of CD93 in the progression of multiple tumors; however, there are few studies examining its immune properties for gliomas. Here, we methodically investigated the pathophysiological characteristics and clinical manifestations of gliomas. Six hundred ninety-nine glioma patients in TCGA along with 325 glioma patients in CGGA were correspondingly collected for training and validating. We analyzed and visualized total statistics using RStudio. One-way ANOVA and Student’st-test were used to assess groups’ differences. All differences were considered statistically significant at the level ofP < 0.05. CD93 markedly upregulated among HGG, MGMT promoter unmethylated subforms, IDH wild forms, 1p19q non-codeletion subforms, and mesenchyme type gliomas. ROC analysis illustrated the favorable applicability of CD93 in estimating mesenchyme subform. Kaplan–Meier curves together with multivariable Cox analyses upon survivance identified high-expression CD93 as a distinct prognostic variable for glioma patients. GO analysis of CD93 documented its predominant part in glioma-related immunobiological processes and inflammation responses. We examined the associations of CD93 with immune-related meta-genes, and CD93 positively correlated with HCK, LCK, MHC I, MHC II, STAT1 and IFN, while adverse with IgG. Association analyses between CD93 and gliomas-infiltrating immunocytes indicated that the infiltrating degrees of most immunocytes exhibited positive correlations with CD93, particularly these immunosuppressive subsets such as TAM, Treg, and MDSCs. CD93 is markedly associated with adverse pathology types, unfavorable survival, and immunosuppressive immunocytes infiltration among gliomas, thus identifying CD93 as a practicable marker and a promising target for glioma-based precise diagnosis and therapeutic strategies.
Anorexia nervosa and familial risk factors: a systematic review of the literature
Authors: Del Casale Antonio , Adriani Barbara , Modesti Martina Nicole , Virzì Serena , Parmigiani Giovanna , Vento Alessandro Emiliano , Speranza Anna Maria 
Published: August 2022

AbstractAnorexia Nervosa (AN) is a psychological disorder involving body manipulation, self-inflicted hunger, and fear of gaining weight.We performed an overview of the existing literature in the field of AN, highlighting the main intrafamilial risk factors for anorexia. We searched the PubMed database by using keywords such as “anorexia” and “risk factors” and “family”. After appropriate selection, 16 scientific articles were identified. The main intrafamilial risk factors for AN identified include: increased family food intake, higher parental demands, emotional reactivity, sexual family taboos, low familial involvement, family discord, negative family history for Eating Disorders (ED), family history of psychiatric disorders, alcohol and drug abuse, having a sibling with AN, relational trauma. Some other risk factors identified relate to the mother: lack of maternal caresses, dysfunctional interaction during feeding (for IA), attachment insecurity, dependence. Further studies are needed, to identify better personalized intervention strategies for patients suffering from AN.
Modified York Mason Procedure for the Closure of a Complex Anterior Fistula in Ano
Authors: Ambe Peter C. 
Published: August 2022

AbstractThe York Mason procedure was initially described for the management of recto-urinary fistulae. Although this procedure may be difficult to perform, success rates and long-term outcomes are encouraging. Adopting this technique for the management of a complex non-recto-urinary fistula in ano may be reasonable. In this manuscript, the York Mason technique was modified to repair a complex type 4 anterior fistula in ano without involvement of the urinary system with good results.
The East Asian Summer Monsoon Response to Global Warming in a High Resolution Coupled Model: Mean and Extremes
Authors: Liu Zhen , Lee Sun-Seon , Nellikkattil Arjun Babu , Lee June-Yi , Dai Lan , Ha Kyung-Ja , Franzke Christian L. E. 
Published: August 2022

AbstractCurrent climate models still have considerable biases in the simulation of the East Asian summer monsoon (EASM), which in turn reduces their reliability of monsoon projections under global warming. We hypothesize that a higher-resolution coupled climate model with atmospheric and oceanic components at horizontal resolutions of 0.25° and 0.1°, respectively, will better capture regional details and extremes of the EASM. Present-day (PD), 2 × CO2 and 4 × CO2 simulations are conducted with the Community Earth System Model (CESM1.2.2) to evaluate PD simulation performance and quantify future changes. Indeed, our PD simulation well reproduces the climatological seasonal mean and intra-seasonal northward advancement of the monsoon rainband, as well as climate extremes. Compared with the PD simulation, the perturbed CO2 experiments show an intensified EASM response to CO2-induced warming. We find that the precipitation increases of the Meiyu-Baiu-Changma band are caused by comparable contributions from the dynamical and thermodynamical components in 2 × CO2, while they are more driven by the thermodynamical component in 4 × CO2 due to stronger upper atmospheric stability. The regional changes in the probability distribution of the temperature show that extreme temperatures warm faster than the most often temperatures, increasing the skewness. Fitting extreme precipitation values with a generalized Pareto distribution model reveals that they increase significantly in 4 × CO2. Changes of temperature extremes scale with the CO2 concentrations over the monsoon domain but not for precipitation extreme changes. The 99th percentile of precipitation over the monsoon region increases at a super Clausius-Clapeyron rate, ~ 8% K–1, which is mainly caused by increased moisture transport through anomalous southerly winds.
Civil infrastructure defect assessment using pixel-wise segmentation based on deep learning
Authors: Savino Pierclaudio , Tondolo Francesco 
Published: August 2022

AbstractNowadays, the number of aging civil infrastructures is growing world-wide and when concrete is involved, cracking and delamination can occur. Therefore, ensuring the safety and serviceability of existing civil infrastructure and preventing an inadequate level of damage have become some of the major issues in civil engineering field. Routine inspections and maintenance are then required to avoid leaving these defects unexplored and untreated. However, due to the limitations of on-field inspection resources and budget management efficiency, automation technology is needed to develop more effective and pervasive inspection processes. This paper presents a pixel-wise classification method to automatically detect and quantify concrete defects from images through semantic segmentation network. The proposed model uses Deeplabv3+ network with weights initialized from pre-trained neural networks. The comparison study among the performance of different deep neural network models resulted in ResNet-50 as the most suitable network for applications of civil infrastructure defects segmentation. A total of 1250 images have been collected from the Internet, on-field bridge inspections and Google Street View in order to build an invariant network for different resolutions, image qualities and backgrounds. A randomized data augmentation allowed to double the database and assign 2000 images for training and 500 images for validation. The experimental results show global accuracies for training and validation of 93.42% and 91.04%, respectively. The promising results highlighted the suitability of the model to be integrated in digitalized management system to increase the productivity of management agencies involved in civil infrastructure inspections and digital transformation.
The Origins of Consciousness or the War of the Five Dimensions
Authors: Veit Walter 
Published: August 2022

AbstractThe goal of this article is to break down the dimensions of consciousness, attempt to reverse engineer their evolutionary function, and make sense of the origins of consciousness by breaking off those dimensions that are more likely to have arisen later. A Darwinian approach will allow us to revise the philosopher’s concept of consciousness away from a single “thing,” an all-or-nothing quality, and towards a concept of phenomenological complexity that arose out of simple valenced states. Finally, I will offer support for an evaluation-first view of consciousness by drawing on recent work in experimental philosophy of mind.
Perrin numbers that are concatenations of two repdigits
Authors: Batte Herbert , Chalebgwa Taboka P. , Ddamulira Mahadi 
Published: August 2022

AbstractLet $$ (P_n)_{n\ge 0}$$

(

P
n

)

n
≥
0

be the sequence of Perrin numbers defined by ternary relation $$ P_0=3 $$

P
0

=
3

, $$ P_1=0 $$

P
1

=
0

, $$ P_2=2 $$

P
2

=
2

, and $$ P_{n+3}=P_{n+1}+P_n $$

P

n
+
3

=

P

n
+
1

+

P
n

for all $$ n\ge 0 $$

n
≥
0

. In this paper, we use Baker’s theory for nonzero linear forms in logarithms of algebraic numbers and the reduction procedure involving the theory of continued fractions, to explicitly determine all Perrin numbers that are concatenations of two repeated digit numbers.
Retrospective Impact Assessment for Pilot Hydroponic Green Fodder Production in Sekota Woreda, Amhara Regional State, Ethiopia
Authors: Kidane Tariku , Dagnachew Alemu 
Published: August 2022

AbstractThe objective of the study was to assess the impact of hydroponic green feed production on the milk production and household income of small-scale farmers in Sekota Woreda (District) of Waghimra zone in Ethiopia. Hydroponic feed production is not a common way of animal feed production. However, an NGO called Action For Hunger (ACF) designed a project and introduced it in two Peasant Associations (PAs) or Kebeles in Sekota Woreda. The technique employs non-soil fodder production with the application of specialized nutrient solutions which replace nutrients that plants can get from the soil. Sekota Woreda under Waghimra zone is found in Amhara region, Ethiopia, characterized by recurrent drought, degraded topography, and minimal amount of vegetation coverage. It is paramount in providing alternative production techniques to small holders in the area and the project introduced non-soil-based animal feed production technique. The project selected totally 50 households for piloting the project. All participating farmers have been included on the impact assessment study. Both descriptive and inferential statistics techniques were employed to characterize beneficiaries and analyze the impact brought about to their livelihood by the project. Descriptive statistics techniques implemented such as mean, frequency, standard deviation, and cross tabulation techniques. Two-sample t test with equal variance assumption is used to analyze the impact in retrospective way of analysis. The results include about 60% of beneficiaries are Female and the rest are Male and most of them are either Widowed or Divorced. Participation criteria for the program were restocking beneficiary, female-headed household, affected by recurrent drought and elderly farmer. When it comes to the impact of the hydroponic feed production activity, it has brought statistically significant improvement in both cattle and goat milk production and the income from the sale of the milk produced by the intervention. Hence, it is recommended that either the project itself or other development practitioners should take the lesson from this activity and think about scaling up the project to other farmers within the District or other Districts within the area.
Unrootedness: a New Surface in the Lacanian Black Split Subject
Authors: Akpan James 
Published: August 2022

AbstractHow is the split black subject symbolized? The article attempts this question with its Lacanian-styled gap-filling (or -opening) method, using two clues — one from The Big Bang Theory sitcom, and the other from Achebe’s Things Fall Apart. The split subject comes before the imaginary, the mirror stage, which begins with the child’s experience of the Parental Other. Colonization and civil rights then become a later stage in the growth process of the black race, where the white acted as a Parental or Significant Other. Amy Farrell Fowler and Sheldon Cooper from CBS’ The Big Bang Theory (Season 6, Episode 21, first aired on April 25, 2013) both symbolically portray the colonial condition of Africa. After several failed attempts to attain gratification from his Significant Other, Cooper’s revolutionary attention to his “split subject’s needs” without Amy offers a new lens to theorize colonization as a “halfway error” to be corrected and transcended to reach where Okonkwo, in Things Fall Apart, fails. The unrootedness of being black would then polish the new surface to which the entire black race globally can behold and do something not done before.