bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis ROA, ROE dan NPM Terhadap Harga Saham Pada Perusahaan Manufaktur yang Terdaftar Di Bursa Efek Indonesia
Authors: Melinda Melinda , Ompusunggu Hermaya 
Published: June 2022

The motive in this research is to analyze and determine the effect of Return on Assets, Return on Equity and Net Profit Margin on stock prices in manufacturing companies listed on Indonesia Stock Exchange from 2016-2020. The population are consumer goods industrial companies listed on the BEI with 61 companies. The sampling technique is use purposive sampling and the criteria for sampling is 26 companies. This reseach get the data is from secondary data in the form of manufacturing company reports. Data collection techniques using financial report documentation from www.idx.co.id. The data obtained by SPPS version 25. The data analysis technique used descriptive statistical analysis, classical assumption test, multiple linear analysis and hypothesis. The results of the research show that the variables of return on assets, return on equity and net profit margin have an influence on stock prices. Furthermore, return on assets has a negative and significant effect on stock prices. Meanwhile, return on equity and net profit margin have a significant and positive impact on the shares of manufacturing companies in the consumer goods industry which are listed on Indonesia Stock Exchange during 2016-2020
Pengaruh Lokasi, Variasi Produk dan Kualitas Pelayanan Terhadap Keputusan Pembelian pada PT Setia Jaya Batam
Authors: Angelyn Angelyn , Nainggolan Nora Pitri 
Published: June 2022

Tujuan pada penelitian ini ialah untuk menganalisis pengaruh lokasi, variasi produk dan kualitas pelayanan yang secara masing-masing (parsial) maupun secara bersamaan (simultan) terhadap keputusan pembelian pada PT Setia Jaya Batam. Teknik sampling yang digunakan dalam penelitian ini adalah Simple Random Sampling. Populasi pada penelitian ini ialah pelanggan PT Setia Jaya Batam dengan jumlah populasi sebanyak 150 Pelanggan. Dengan mengangkat sebanyak 109 responden sebagai sampel. Dan menggunakan bantuan software SPSS 25 untuk menghitung hasil uji. Hasil pada penelitian ini membuktikan bahwa secara parsial lokasi, variasi produk beserta kualitas pelayanan memliki pengaruh yang signifikan terhadap keputusan pembelian pada PT Setia Jaya Batam, dengan niali t hitung lokasi (X1) 2,232 > t tabel 1,983, variasi produk (X2) t hitung 3,134 > t tabel 1,983, kualitas pelayanan (X3) t hitung 2,859 > t tabel 1,983. Pada hasil penelitian ini juga membuktikan bahwa secara bersama-sama (simultan) lokasi, variasi produk dan kualitas pelayanan memiliki pengaruh yang signifikan terhadap keputusan pembelian pada PT Setia Jaya Batam.
Pengaruh Tingkat Pemahaman Perpajakan, Penerapan E-Filing Dan Kesadaran Wajib Pajak Terhadap Kepatuhan Wajib Pajak Orang Pribadi Dalam Menyampaikan Spt Tahunan
Authors: CHRISTIAN CHRISTIAN , Jenni Jenni 
Published: June 2022

Sektor pajak mempunyai peranan penting dalam pelaksanaan pembangunan nasional, akan tetapi masih ada wajib pajak yang tidak memiliki kepatuhan dalam membayar pajak ataupun prilaku untuk menghindari pelaporan perpajakan, sehingga realisasi penerimaan pajak tidak mencapai target. Penelitian ini bertujuan untuk mengetahui pengaruh tingkat pemahaman perpajakan, penerapan e-filing dan kesadaran wajib pajak terhadap kepatuhan wajib pajak orang pribadi di PT.Sinar Kosambi. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif. Pengumpulan data dan informasi dalam penelitian ini dilaksanakan dengan studi lapangan yaitu melalui penyebaran kuesioner sebagai alat penelitian yang di sebar kepada responden di PT.Sinar Kosambi. Pengambilan sampel dalam penelitian ini adalah convinience sampling yaitu dimana informasi diambil dari anggota populasi yang bersedia memberikan informasi dan dianggap cocok dengan cici – ciri sampel yang ditentukan. Teknisa nalisis data yaitu regresi linear bergada dengan menggunakan software SPSS versi 25. Berdasarkan data yang diperoleh dari hasil penelitian, variable independen yaitu tingkat pemahaman perpajakan memilikinilai sig. 0.026 lebih kecil dari nilai 0,05 dan variable independen penerapan e-filing memiliki nilai sig.0.035 lebih kecil dari nilai 0,05 serta variabel independen kesadaran wajib pajak memiliki sig. 0.00 lebih kecil dari 0,05. Kesimpulan dari hasil penelitian ini adalah tingkat pemahaman perpajakan, penerapan e-filing dan kesadaran wajib pajak berpengaruh signifikan terhadap kepatuhan wajib pajak orang pribadi.
Soluble IL-33 receptor predicts survival in acute kidney injury
Authors: Erfurt Stefan , Hoffmeister Meike , Oess Stefanie , Asmus Katharina , Patschan Susann , Ritter Oliver , Patschan Daniel 
Published: June 2022

Introduction: The prediction of acute kidney injury (AKI)-related outcomes remains challenging. Herein we prospectively quantified soluble ST2 (sST2), the circulating isoform of the IL-33 receptor, in hospitalized patients with AKI.
Methods: In-hospital subjects with AKI of various etiology were identified through the in-hospital AKI alert system of the Brandenburg University hospital. sST2 was measured within a maximum of 48 hours from the time of diagnosis of AKI. The following endpoints were defined: in-hospital death, dialysis, recovery of kidney function until demission.
Results: In total, 151 individuals were included in the study. The in-hospital mortality was 16.6%, dialysis therapy became mandatory in 39.7%, no recovery of kidney function occurred in 27.8%. sST2 was significantly higher in nonsurvivors (p = 0.024) but did not differ in the two other endpoints. The level of sST2 increased significantly with the severity of AKI. Further differences were detected in subjects with heart insufficiency (lower sST2), and in patients that required ICU treatment, or ventilatory therapy, or vasopressors (all higher).
Conclusions: The current study suggests sST2 as biomarker of “acute distress”: it predicts post-AKI survival and substantially increases in subjects with a higher degree of cumulative morbidity under acute circumstances (e.g., ICU therapy, vasopressor administration).
Ansiedade, depressão e estresse percebido em pacientes no pré-operatório por câncer colorretal: um estudo transversal
Authors: Teles André Aparecido da Silva , Correa Júnior Antonio Jorge Silva , Aguiar Janderson Cleiton , Neves Wagner Felipe dos Santos , Paraizo-Horvath Camila Maria Silva , Russo Tatiana Mara da Silva , Dessotte Carina Aparecida Marosti , Sonobe Helena Megumi 
Published: June 2022

Objetivo: Avaliar os sintomas de ansiedade, depressão e estresse percebido em pacientes no pré-operatório imediato da primeira cirurgia eletiva por Câncer Colorretal; e investigar a associação/correlação desses sintomas com variáveis sociodemográficas e clínicas. Metodologia: estudo observacional, analítico, de corte transversal, com 89 pacientes em um hospital universitário público do Estado de São Paulo, Brasil. Utilizou-se a Hospital Anxiety and Depression Scale (HADS) para avaliação dos sintomas de ansiedade e depressão, e a Brazilian Perceived Stress Scale (BPSS-10) para o estresse percebido, além de um roteiro para obtenção de dados sociodemográficos e clínicos. Resultados: Houve discreta predominância de mulheres (50,6%); média de idade de 61,8 anos e de 7,3 anos de estudo; 78,7% declararam-se brancos; 60,7% com companheiro e 76,4% inativos profissionalmente, cujo escore médio de ansiedade foi 7,4 (mediana= 8, DP=4,1), de depressão foi 4,2 (mediana= 3, DP=3,8) e de estresse percebido foi 20,0 (mediana= 19, DP=7,6). As mulheres e os pacientes com menos de 60 anos apresentaram mais sintomas de ansiedade e estresse percebido; os homens e os idosos apresentaram mais sintomas de depressão. Houve forte correlação entre os sintomas de ansiedade, depressão e estresse percebido, além de correlação moderada entre estresse percebido e o tempo para início do tratamento, todas estatisticamente significantes. Conclusão: Embora os pacientes tenham apresentado diferentes níveis de ansiedade, depressão e o estresse percebido no pré-operatório imediato, não houve associação/correlação estatisticamente significante entre estes sintomas com outras variáveis sociodemográficas e clínicas.
Análise da produção científica sobre a contaminação por SARS-CoV-2 no período gestacional
Authors: Ibiapina João Paulo Barros , Araujo Gustavo Baroni , Fillis Michelle Moreira Abujamra , Serassuelo Junior Hélio , Moura Maria Eliete Batista 
Published: June 2022

Grande parte das produções científicas atuais tem como objetivo investigar as consequências provocadas pela infecção do vírus causador da COVID-19. Sabe-se que esse vírus apresenta relação direta com inúmeras mortes de mulheres grávidas e, por essa razão, entende-se a necessidade de investigar os fatores associados ao SARS-CoV-2 na gravidez. O objetivo deste estudo é analisar a partir da literatura científica, as consequências associadas à COVID-19 no período gestacional. Trata-se de um estudo de revisão integrativa, realizado após uma análise bibliométrica na ISI Web of Knowledge/Web of Science™ no recorte temporal de 2020 e 2021, por meio dos descritores “Pregnancy” AND “COVID-19” AND “Woman”. Os artigos foram selecionados e classificados em ordem de maior relevância a partir da exportação dos dados para o software de análise bibliométrica HistCite™. Foram selecionados os cinco artigos que apresentaram maiores índices de citação segundo os resultados fornecidos pelo software. Os resultados evidenciam principalmente alterações nos domínios psicossociais no período gestacional e que a infecção pelo vírus SARS-CoV-2 em casos clínicos mais graves estão associadas a condições patológicas já existentes. Observa-se que mulheres no terceiro trimestre de gestação possuem maiores chances de agravamentos clínicos por SARS-CoV-2 principalmente ao apresentarem quadros de obesidade, hipertensão e cardiopatias. Para que os prejuízos à saúde da mulher e do feto sejam irrisórios, sugere-se os cuidados em saúde no contexto multidisciplinar, considerando a importância da saúde integral no período de gestação e diante da exposição ao vírus SARS-CoV-2.
Método Pilates no controle da diabetes em gestantes: revisão sistemática
Authors: Oliveira Layla Giovana Santos , Silva Maria Rosa da , Ventura Patrícia Lima 
Published: June 2022

A gestação é um período de muitas mudanças no corpo da mulher destinadas a promover o crescimento do feto. A diabetes mellitus gestacional (DMG) é definida como intolerância a carboidratos que ocorre pela primeira vez durante a gestação. O exercício físico tem benefícios e riscos mínimos para mulheres grávidas, e é importante para a saúde de mulheres com diabetes mellitus gestacional. O método pilates é um sistema de exercícios com base na filosofia e princípios do corpo, mente e espirito. Este estudo teve como objetivo mostrar se a prática do pilates é realmente efetiva quando comparada aos efeitos do exercício físico padrão durante a gestação em mulheres com diabetes, de modo que essa prática irá contribuir para o controle dos níveis de glicemia no sangue. Foram realizadas as buscas nas bases: PEDro (Physiotherapy Evidence Database), PubMed (National Library of Medicine) e BVS (Biblioteca Virtual de Saúde). Nos resultados apenas 04 ensaios clínicos randomizados de 116 foram relevantes e que cumpriram os critérios de elegibilidade de acordo com avaliação da qualidade de metodológica da Escala PEDro. Na análise discursiva os artigos expostos neste estudo, foram analisados de acordo com idade gestacional das participantes, intervenções de exercícios físicos padrão quanto a redução da diabetes mellitus em gestantes. Entretanto não houve diferenças estatisticamente significativas entre os grupos de intervenção, deste modo as evidências eram insuficientes para sugerir que o exercício físico durante a gravidez pode ser eficaz na redução do risco de diabete mellitus gestacional e na redução dos níveis glicêmicos.
Combination therapy with antipsychotics and antidepressants (pharmacological approach)
Authors: Kozlovskii V. L. , Popov M. Yu. , Kosterin D. N. , Lepik O. V. 
Published: June 2022

Objective. To perform a pharmacological analysis of treatment received by patients with schizophrenia spectrum disorders and to elaborate the principles of combination therapy with antipsychotics and antidepressants based on pharmacodynamics and pharmacokinetics.Materials and methods. The study included 311 inpatients with schizophrenia spectrum disorders admitted to the V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology for the management of treatment resistance. A comprehensive pharmacological analysis was performed including a retrospective evaluation of the quality of patients’ treatment (based on their medical records) and a comparison of the neurochemical activity of the drugs in order to determine the rationality of combined use of antipsychotics and antidepressants. Statistical analysis included descriptive statistics and frequency analysis.Results. An analysis of treatment data for 311 patients has demonstrated that given the signiﬁcant frequency of combined administration of antipsychotics and antidepressants (29.3%), the choice of drugs was based on clinical judgment, without considering the pharmacological effects of the drugs being used. A comparison of pharmacodynamics has allowed to arrange antipsychotics and antidepressants according to their binding afﬁnities to neurochemical targets. A methodological approach to evaluating the compatibility of combined drugs based on their neurochemical activity and afﬁnity to speciﬁc receptors has been argued. The principles of combination therapy with antipsychotics antidepressants have been elaborated.Conclusion. Combined use of an antipsychotic and an antidepressant without considering their ‘neurochemical compatibility’ regarding postsynaptic targets may decrease efﬁcacy and potentiate adverse effects. In combination therapy with an antipsychotic and an antidepressant, drugs should be started one at a time taking into account their pharmacokinetics in order to avoid the possibility of competitive neurochemical effects prior to establishing a speciﬁc drug homeostasis. The development of rational strategies for combination therapy should be based on the assessment of pharmacodynamics and pharmacokinetics of the drugs.
Concept of 5P-medicine for prevention of acute cerebral ischemia in women
Authors: Manysheva K. B. 
Published: June 2022

The objective. To evaluate the effectiveness of the 5P-model for the prevention of acute cerebral ischemia in Dagestan women.Materials and methods. The prospective study included 35 women permanently residing in Dagestan. The mean age was 66.46 ± 10.9 years. Each participant of the study was individually interviewed and examined clinically, neurologically, an additional examination included: complete blood test, biochemical blood test, coagulation test, molecular genetic study for 11 candidate gene mutations signiﬁcant for the occurrence of ischemic stroke, electrocardiography, neuroimaging.Results. By analyzing the results of the study, individual background conditions that predispose to the occurrence of ischemic stroke were established. The results of the examination were explained to each participant, there were given the recommendations on lifestyle modiﬁcation, a diet was prescribed and the necessary therapy was selected. In the process of dynamic observation for 4 years the observed group had no episodes of acute cerebrovascular accident.Conclusions. The study conﬁrms the effectiveness of the use of the 5P-model for the prevention of acute cerebral ischemia in women Dagestan and declare a positive experience of its application.
The Microbiology of Non-aeruginosa Pseudomonas Isolated From Adults With Cystic Fibrosis: Criteria to Help Determine the Clinical Significance of Non-aeruginosa Pseudomonas in CF Lung Pathology
Authors: Moore John E. , McCaughan John , Rendall Jacqueline C. , Millar Beverley C. 
Published: June 2022

Introduction: There is a paucity of reports on non-aeruginosa Pseudomonas (NAPs) in cystic fibrosis, hence this study wished 1). to examine the diversity/frequency of NAPs in an adult CF population, 2) to compare/contrast the microbiology and genomics of NAPs to P. aeruginosa and 3) to propose clinical and laboratory criteria to help determine their clinical significance in CF lung pathology.Materials and Methods: Microbiological data was examined from 100 adult patients with cystic fibrosis from birth to present (31/12/2021), equating to 2455 patient years. 16S rDNA phylogenetic relatedness of NAPs was determined, as well as bioinformatical comparison of whole genomes of P. aeruginosa against P. fluorescens.Results: Ten species were isolated from this patient cohort during this time period, with three species, i.e., P. fluorescens, P. putida and P. stutzeri, accounting for the majority (87.5%) of non-aeruginosa reports. This is the first report of the isolation of P. fragi, P. nitroreducens, P. oryzihabitans and P. veronii in patients with cystic fibrosis. The mean time to first detection of any non-aeruginosa species was 183 months (15.25 years) [median = 229 months (19.1 years)], with a range from 11 months to 338 months (28.2 years). Several of the NAPs were closely related to P. aeruginosa.Discussion: NAPs were isolated infrequently and were transient colonisers of the CF airways, in those patients with CF in which they were isolated. A set of ten clinical and laboratory criteria are proposed to provide key indicators, as to the clinical importance of the non-aeruginosa species isolated.
Methane Emission Reduction and Biological Characteristics of Landfill Cover Soil Amended With Hydrophobic Biochar
Authors: Qin Yongli , Xi Beidou , Sun Xiaojie , Zhang Hongxia , Xue Chennan , Wu Beibei 
Published: June 2022

Biochar-amended landfill cover soil (BLCS) can promote CH4 and O2 diffusion, but it increases rainwater entry in the rainy season, which is not conducive to CH4 emission reduction. Hydrophobic biochar–amended landfill cover soil (HLCS) was prepared to investigate the changes in CH4 emission reduction and biological characteristics, and BLCS was prepared as control. Results showed that rainwater retention time in HLCS was reduced by half. HLCS had a higher CH4 reduction potential, achieving 100% CH4 removal at 25% CH4 content of landfill gas, and its main contributors to CH4 reduction were found to be at depths of 10–30 cm (upper layer) and 50–60 cm (lower layer). The relative abundances of methane-oxidizing bacteria (MOB) in the upper and lower layers of HLCS were 55.93% and 46.93%, respectively, higher than those of BLCS (50.80% and 31.40%, respectively). Hydrophobic biochar amended to the landfill cover soil can realize waterproofing, ventilation, MOB growth promotion, and efficient CH4 reduction.
Pore Strategy Design of a Novel NiTi-Nb Biomedical Porous Scaffold Based on a Triply Periodic Minimal Surface
Authors: Lv Yuting , Liu Guohao , Wang Binghao , Tang Yujin , Lin Zhengjie , Liu Jia , Wei Guijiang , Wang Liqiang 
Published: June 2022

The pore strategy is one of the important factors affecting the biomedical porous scaffold at the same porosity. In this work, porous scaffolds were designed based on the triply periodic minimal surface (TPMS) structure under the same porosity and different pore strategies (pore size and size continuous gradient distribution) and were successfully prepared using a novel Ni46.5Ti44.5Nb9 alloy and selective laser melting (SLM) technology. After that, the effects of the pore strategies on the microstructure, mechanical properties, and permeability of porous scaffolds were systematically investigated. The results showed that the Ni46.5Ti44.5Nb9 scaffolds have a low elastic modulus (0.80–1.05 GPa) and a high ductility (15.3–19.1%) compared with previous works. The pore size has little effect on their mechanical properties, but increasing the pore size significantly improves the permeability due to the decrease in specific surfaces. The continuous gradient distribution of the pore size changes the material distribution of the scaffold, and the smaller porosity structure has a better load-bearing capacity and contributes primarily to the high compression strength. The local high porosity structure bears more fluid flow, which can improve the permeability of the overall scaffold. This work can provide theoretical guidance for the design of porous scaffolds.
Sample Preparation and Warping Accuracy for Correlative Multimodal Imaging in the Mouse Olfactory Bulb Using 2-Photon, Synchrotron X-Ray and Volume Electron Microscopy
Authors: Zhang Yuxin , Ackels Tobias , Pacureanu Alexandra , Zdora Marie-Christine , Bonnin Anne , Schaefer Andreas T. , Bosch Carles 
Published: June 2022

Integrating physiology with structural insights of the same neuronal circuit provides a unique approach to understanding how the mammalian brain computes information. However, combining the techniques that provide both streams of data represents an experimental challenge. When studying glomerular column circuits in the mouse olfactory bulb, this approach involves e.g., recording the neuronal activity with in vivo 2-photon (2P) calcium imaging, retrieving the circuit structure with synchrotron X-ray computed tomography with propagation-based phase contrast (SXRT) and/or serial block-face scanning electron microscopy (SBEM) and correlating these datasets. Sample preparation and dataset correlation are two key bottlenecks in this correlative workflow. Here, we first quantify the occurrence of different artefacts when staining tissue slices with heavy metals to generate X-ray or electron contrast. We report improvements in the staining procedure, ultimately achieving perfect staining in ∼67% of the 0.6 mm thick olfactory bulb slices that were previously imaged in vivo with 2P. Secondly, we characterise the accuracy of the spatial correlation between functional and structural datasets. We demonstrate that direct, single-cell precise correlation between in vivo 2P and SXRT tissue volumes is possible and as reliable as correlating between 2P and SBEM. Altogether, these results pave the way for experiments that require retrieving physiology, circuit structure and synaptic signatures in targeted regions. These correlative function-structure studies will bring a more complete understanding of mammalian olfactory processing across spatial scales and time.
Synthesis of Benzylidene Analogs of Oleanolic Acid as Potential α-Glucosidase and α-Amylase Inhibitors
Authors: Ke Jun-Jie , Lin Jing , Zhang Xin , Wu Xiao-Zheng , Zheng Ying-Ying , Hu Chun-Mei , Kang Yu , Zhang Kun , Xiong Zhuang , Ma Zhi-Qiang 
Published: June 2022

A series of benzylidene analogs of oleanolic acid 4a∼4s were synthesized and assessed for their α-glucosidase and α-amylase inhibitory activities. The results presented that all synthesized analogs exhibited excellent-to-moderate inhibitory effects on α-glucosidase and α-amylase. Analog 4i showed the highest α-glucosidase inhibition (IC50: 0.40 μM), and analog 4o presented the strongest α-amylase inhibition (IC50: 9.59 μM). Inhibition kinetics results showed that analogs 4i and 4o were reversible and mixed-type inhibitors against α-glucosidase and α-amylase, respectively. Simulation docking results demonstrated the interaction between analogs and two enzymes. Moreover, analogs 4i and 4o showed a high level of safety against 3T3-L1 and HepG2 cells.
Novel Pyrimidine Derivatives Bearing a 1,3,4-Thiadiazole Skeleton: Design, Synthesis, and Antifungal Activity
Authors: Pan Nianjuan , Liu Chunyi , Wu Ruirui , Fei Qiang , Wu Wenneng 
Published: June 2022

In this study, twenty novel pyrimidine derivatives bearing a 1,3,4-thiadiazole skeleton were designed and synthesized. Then their antifungal activity against Botrytis cinereal (B. cinereal), Botryosphaeria dothidea (B. dothidea), and Phomopsis sp. were determined using the poison plate technique. Biological test results showed that compound 6h revealed lower EC50 values (25.9 and 50.8 μg/ml) on Phompsis sp. than those of pyrimethanil (32.1 and 62.8 μg/ml).