bluuebunny/crossref_metadata_2025_split huggingface dataset:
AA147 ameliorates post-cardiac arrest cerebral ischemia/reperfusion injury through the co-regulation of the ATF6 and Nrf2 signaling pathways
Authors: Yuan Zhu , Lu Liping , Lian Yingtao , Zhao Yuanrui , Tang Tingting , Xu Song , Yao Zhun , Yu Zhui 
Published: November 2022

Ischemia/reperfusion caused by cardiac arrest (CA) disturbs endoplasmic reticulum (ER) homeostasis and redox balance in neurons. AA147, originally developed as a pharmacologic activator of the activating transcription factor 6 (ATF6), can protect multiple tissues from ischemia/reperfusion injury (IRI) by decreasing reactive oxygen species (ROS) and restoring ER function. However, it is unclear whether pharmacologic treatment of AA147 could ameliorate post-CA cerebral IRI and whether it is associated with proteostasis regulation and anti-oxidative stress mechanism. In the present study, mice were subjected to 9 min-CA surgery followed by cardiopulmonary resuscitation (CPR). AA147 or vehicle was administered 1 day before the operation and 15 min after the return of spontaneous circulation. We found that AA147 restored neurological function and reduced dead neurons in mice suffering from CA. Moreover, AA147 inhibited CA/CPR-caused neuronal apoptosis and ER stress, indicated by reduced TUNEL-positive neurons, surged expression of Bcl-2/Bax, and down expression of cleaved caspase-3, caspase-12, C/EBP homologous protein (CHOP). The expression of ATF6 and its regulated gene glucose-regulated protein 78 (GRP78) increased significantly after the administration of AA147, suggesting the activation of the ATF6 pathway. In addition, AA147 also alleviated the upsurge of the ROS generation and MDA levels as well as increased SOD activity, accompanied by enhancement of the nuclear factor E2-related factor 2 (Nrf2) and its modulated heme-oxygenase-1 (HO-1) expressions. Cotreatment of AA147 with inhibitors of the ATF6 or Nrf2 significantly suppressed AA147-dependent reductions in ROS scavenging and neuronal death after CA/CPR. The results suggested that AA147 could confer neuroprotection against post-CA cerebral IRI through inhibition of oxidative stress along with ER stress-associated apoptosis, which is attributed to the coregulation of both ATF6 and Nrf2 signaling pathways activity. Our findings support the potential for AA147 as a therapeutic approach to improve post-CA brain injury.
Acute and sub-acute toxicity evaluation of dihydro-p-coumaric acid isolated from leaves of Tithonia diversifolia Hemsl. A. Gray in BALB/c mice
Authors: Devi Thiyam B. , Jena Sarita , Patra Biswajit , Singh Kabrambam D. , Chawla Saurabh , Raina Vishakha , Koijam Arunkumar Singh , Parida Ajay , Rajashekar Yallappa 
Published: November 2022

In present study, the acute and sub-acute toxicities of Dihydro-p-coumaric acid isolated from the leaves of Tithonia diversifolia (Hemsl.) A. Gray was studied for safety issues in mammals. For acute toxicity tests, isolated compound was administered orally in both male and female BALB/c mice at the doses of 200, 800, and 1,600 mg/kg body weight for 7 days. In sub-acute toxicity study 50 and 500 mg/kg bw of the compound was orally administered for 14 days. Toxicity induced behavioural changes, haematological parameters, biochemical markers and histopathological sections were studied after Dihydro-p-coumaric acid administration. The vital organs like heart, kidney, uterus and testis revealed no adverse effects at doses of upto 1,600 mg/kg bw and 500 mg/kg bw. Slight hepatotoxicity was however demonstrated by ALT and AST assay but histopathological section did not concur as much. The study demonstrated insignificant difference in the percentage of feed intake, water intake, weight gain, haematological parameters and histopathological changes, with no toxicity signs and mortality. Dihydro-p-coumaric acid can be regarded as safe in both acute and sub-acute toxicity assay in both sexes. This indicates Dihydro-p-coumaric acid as a viable alternative to synthetic pesticides.
Inter-individual responses of post-exercise hypotension in older adults with hypertension: An exploratory analysis of different exercise modalities
Authors: Carpes Leandro O. , Domingues Lucas B. , Bertoletti Otávio , Fuchs Sandra C. , Ferrari Rodrigo 
Published: November 2022

Background: Various physical exercise modalities can acutely reduce blood pressure (BP). However, not all individuals respond similarly after an exercise session.Purpose: To measure inter-individual variations in 24-h BP after a single bout of various exercise modalities in older adults with hypertension.Methods: This retrospective study analyzed data from participants with hypertension (≥60 years) previously included in three randomized controlled trials on this topic. BP was assessed using ambulatory BP monitoring. We compared the mean changes in total 24-h, daytime, and nighttime BP after aerobic (AE, n = 19), combined (COMB, n = 19), resistance (RES, n = 23), and isometric handgrip (ISO, n = 18) exercise sessions to a non-exercising control session (C). The minimum detectable changes to classify the participant as a “Responder” for the corresponding exercise protocol were 4 and 2 mmHg for systolic and diastolic BP, respectively.Results: The prevalence of Responders for systolic BP was as follows: AE 24-h: 37%, daytime: 47% and nighttime: 37%; COMB 24-h: 26%, daytime: 21% and nighttime: 32%; RES 24-h: 26%, daytime: 26% and nighttime: 35%; and ISO 24-h: 22%, daytime: 22% and nighttime: 39%. For diastolic BP, the prevalence of Responders was as follows: AE 24-h: 53%, daytime: 53% and nighttime: 31%; COMB 24-h: 26%, daytime: 26% and nighttime: 31%; RES 24-h: 35%, daytime: 22% and nighttime: 52%; and ISO 24-h: 44%, daytime: 33% and nighttime: 33%.Conclusion: There was a high inter-individual variation of BP after a single bout of various exercises in older adults. Responders had higher BP values on the control day without exercise. Various exercise modalities might acutely reduce 24-h BP in older adults with hypertension.
The association between sharing something difficult on social media and mental well-being among adolescents. Results from the “LifeOnSoMe”-study
Authors: Kysnes Bjarte , Hjetland Gunnhild Johnsen , Haug Ellen , Holsen Ingrid , Skogen Jens Christoffer 
Published: November 2022

IntroductionSocial media use is part of everyday life for adolescents. Over the last decade, concerns about the potential negative effects of social media use on mental health and well-being has been raised. Possible positive effects of social media use have to a lesser extent been explored. However, some studies have found associations between social support on social media and well-being. Self-disclosing thoughts and feelings on social media might provide social support and positively affect well-being. The current study aimed to explore adolescents’ experiences with sharing something difficult on social media and the association with well-being.MethodsThe survey data in this cross-sectional study were collected from a sample of 2023 adolescents from senior high schools (mean age 17.4, 55.6% females). Mental well-being was measured using the Warwick-Edinburgh Mental Well-being scale (WEMWBS). Multiple linear regression adjusting for age, gender, social media frequency/duration of use, and the number of close friends was used to explore the association of sharing something difficult on social media and mental well-being.ResultsThe findings indicated that sharing something difficult on social media, either with a few friends/family members or in a public post, was associated with lower well-being. Perceived social support (easier to talk about, received support, positive experience) after sharing something difficult was associated with higher well-being. Females reported sharing something difficult more than boys, but no interaction effect of gender was found in the associations between private or public sharing and well-being.DiscussionThe results indicate that social media can serve as a supportive environment for adolescents. Future research may want to explore additional aspects of adolescents’ social media use, sharing, and well-being, such as differences in public and private sharing. Such contributions will increase the knowledge base of optimal ways to seek social support through social media.
Remain or return? An empirical study of influencing factors on the return of Chinese international students during the COVID-19 pandemic
Authors: Zhang Keming , Zeng Neng , Zhang Kesen 
Published: November 2022

BackgroundCOVID-19 is now a global public health crisis with unprecedented political, economic, and social consequences affecting nations across the world. It also has a profound impact on the mobility of international students. When the COVID-19 was under control in China, and it was spreading dramatically in the United Kingdom, Chinese international students studying in the United Kingdom have been caught in a double bind over whether to return home or not.ObjectiveThis study aims to explore the factors that influenced Chinese international students’ choices of return during the COVID-19 pandemic when the COVID-19 was under control in China, while it was spreading dramatically in the United Kingdom.MethodsTaking Chinese international students studying in the United Kingdom as an empirical case, this study used qualitative and quantitative research methods to explore the factors that influenced their choices of return. Based on the Rational Choice Theory and qualitative analysis of text data, this paper constructed the influencing factors model of returning to China. On this basis, we developed a questionnaire and collected data from 1,333 students in late April and early May 2020. Binary Logistic Regression with 95% CI for odds ratio (OR) was used to identify significant factors.ResultsThe reserve of epidemic prevention supplies (OR = 0.712), transportation expenses (OR = 0.618), and quarantine expenses (OR = 0.702) negatively affected the return choice of overseas students. The supply of daily necessities (OR = 1.495), the anti-epidemic policy of the United Kingdom (OR = 1.684), and the demand for job hunting after graduation (OR = 1.661) had positive effects.ConclusionThe institutional rationality had the biggest promoting effect, replaced development rationality, and became the most important factor for overseas students to return to China during the COVID-19 pandemic. Economic rationality, which has a significant negative effect, is the biggest obstacle to returning home. These conclusions have policy implications for governments’ response to the COVID-19 epidemic and improvement of the quality of services for overseas students.
Do clinical trials affect anxiety, depression, and quality of life in the caregivers of patients with cancer?
Authors: Guo Xiaotong , Lin Lede , Qiu Xiaohua , Tian Meng , Zhu Jiang 
Published: November 2022

ObjectiveTo investigate the effect of clinical trials on anxiety, depression, and the quality of life experienced by the family caregivers (FCs) of cancer patients.Materials and methodsWe screened the FCs of patients who were participating in clinical trials and FCs of patients who were not participating in clinical trials [group FCs-GCP (FG) and group FCs-non-GCP (FNG) at Cancer Center of West China Hospital]. We assessed the anxiety, depression, and quality of life of the FCs using the Hospital Anxiety and Depression Scale and SF-12. The demographic characteristics of FCs and patients were analyzed.ResultsThe prevalences of anxiety and depression showed no significant difference between FG and FNG (46.3 vs. 51.5%, P = 0.604; 36.6 vs. 51.5%, P = 0.131, respectively). Physical Component Scores (PCS) were 48.87 ± 7.67 for FG and 48.01 ± 8.12 for FNG (P = 0.618) while Mental Component Scores (MCS) were 48.92 ± 7.78 and 44.89 ± 11.42, respectively (P = 0.031). The anxiety of FCs was positively associated with patients’ advanced disease (HR 4.292 [1.409, 13.072], P = 0.010) and initial treatment (HR 3.105 [1.014, 9.515], P = 0.047). Depression was positively related to advanced disease (HR 3.347 [1.140, 9.832], P = 0.028), and negatively related to patients participating in clinical trials (HR 0.421 [0.180, 0.985], P = 0.046) and the education degree of FCs (HR 0.355 [0.149, 0.843], P = 0.019). MCS was positively associated with patients participating in clinical trials (β = 5.067, 95% CI [0.817, 9.317], P = 0.020) and negatively associated with advanced disease (β = −8.055, 95% CI [−19.804, 6.528], P = 0.002).ConclusionThe FCs of the cancer patients who participated in clinical trials showed a comparable worrying situation of anxiety and depression to the FCs of regular cancer patients. This indicates that more concern and attention should be given to this population, and further study on them is warranted.
Tailoring implementation strategies for scale-up: Preparing to take the Med-South Lifestyle program to scale statewide
Authors: Leeman Jennifer , Draeger Lindy B. , Lyons Kiira , Pham Lisa , Samuel-Hodge Carmen 
Published: November 2022

BackgroundTailoring implementation strategies for scale-up involves engaging stakeholders, identifying implementation determinants, and designing implementation strategies to target those determinants. The purpose of this paper is to describe the multiphase process used to engage stakeholders in tailoring strategies to scale-up the Med-South Lifestyle Program, a research-supported lifestyle behavior change intervention that translates the Mediterranean dietary pattern for the southeastern US.MethodsGuided by Barker et al. framework, we tailored scale-up strategies over four-phases. In Phase 1, we engaged stakeholders from delivery systems that implement lifestyle interventions and from support systems that provide training and other support for statewide scale-up. In Phase 2, we partnered with delivery systems (community health centers and health departments) to design and pilot test implementation strategies (2014–2019). In Phase 3, we partnered with both delivery and support systems to tailor Phase 2 strategies for scale-up (2019–2021) and are now testing those tailored strategies in a type 3 hybrid study (2021–2023). This paper reports on the Phase 3 methods used to tailor implementation strategies for scale-up. To identify determinants of scale-up, we surveyed North Carolina delivery systems (n = 114 community health centers and health departments) and elicited input from delivery and support system stakeholders. We tailored strategies to address identified determinants by adapting the form of Phase 2 strategies while retaining their functions. We pilot tested strategies in three sites and collected data on intermediate, implementation, and effectiveness outcomes.FindingsDeterminants of scale-up included limited staffing, competing priorities, and safety concerns during COVID-19, among others. Tailoring yielded two levels of implementation strategies. At the level of the delivery system, strategies included implementation teams, an implementation blueprint, and cyclical small tests of change. At the level of the support system, strategies included training, educational materials, quality monitoring, and technical assistance. Findings from the pilot study provide evidence for the implementation strategies' reach, acceptability, and feasibility, with mixed findings on fidelity. Strategies were only moderately successful at building delivery system capacity to implement Med-South.ConclusionsThis paper describes the multiphase approach used to plan for Med-South scale-up, including the methods used to tailor two-levels of implementation strategies by identifying and targeting multilevel determinants.
The probability analysis of ejecta particles damaging a spacecraft operating around asteroids after an artificial impact experiment: Hayabusa 2 ’s SCI operation safety study
Authors: Soldini Stefania , Saiki Takanao , Tsuda Yuichi 
Published: November 2022

On 5 April 2019, the Hayabusa 2 spacecraft performed the first successful artificial impact experiment on an asteroid. The Small Carry-on Impactor (SCI) device was deployed at an altitude of 500 m above Ryugu’s surface. The 2 kg copper projectile hit Ryugu’s surface in 40 min and caused the formation of an artificial crater 14.5 m in diameter. Once the SCI was deployed, the Hayabusa 2 spacecraft performed a two-week escape trajectory reaching altitudes as far as 120 km from Ryugu. The spacecraft then returned to its nominal position at 20 km altitude (Home-Position) from Ryugu for hovering control. This was done to prevent ejecta particles from seriously damaging the spacecraft and compromising its functionality. In this article, we present a method to forecast the daily probability of spacecraft damage along the selected nominal escape trajectory due to the debris cloud formed by an artificial impact. The result of the damage analysis confirmed that the selected escape trajectory experienced a small number of particle collisions under the design threshold, which would not have resulted in damage. Indeed, no damage was reported on the Hayabusa 2 spacecraft and it kept operating normally after the SCI operation. The method here presented serves as a guideline for post-impact mission operations to forecast and estimate the probability of damage to spacecraft or CubeSats operating near a small celestial body after an artificial impact experiment has occurred.
Prostate volume is an independent predictive factor in selecting low-risk prostate patients for active surveillance
Authors: Yusim Igor , Mazor Elad , Elsaraya Nimer , Gat Roni , Novack Victor , Mabjeesh Nicola J. 
Published: November 2022

PurposeThe outcome of the present study is to determine variables available at the time of diagnosis able to predict disease reclassification in prostate cancer (PCa) patients on active surveillance (AS).Materials and methodsFrom January 2014 to December 2018, 114 consecutive low-risk PCa patients were enrolled in AS protocol according to inclusion criteria: PSA ≤ 10 ng/ml, Gleason score (GS) ≤ 6 or International Society of Urological Pathology (ISUP) Gleason grade group (GG) 1, maximum cancer core length (MCCI) &lt; 50%, and ≤ 2 positive cores on biopsy. Patients were followed with confirmatory and yearly prostate biopsy, semi-annually with prostate-specific antigen (PSA), and digital rectal examination (DRE). Disease reclassification was defined as upgrading biopsy: GS ≥ 3 + 4 = 7 or ISUP GG ≥ 2, more than two positive cores, MCCI &gt; 50%, or changes in serum PSA &gt; 10 ng/ml. Uni- and multivariate Cox proportional hazards regression models, receiver performance curves (ROC), and Kaplan-Meier analysis were performed to characterize AS criteria and identify variables that predict disease reclassification. Finally, decision curve analysis (DCA) was performed to evaluate the net benefit of using PV in addition to standard variables to predict disease reclassification.ResultsPCa was diagnosed by systematic transrectal ultrasound-guided prostate biopsy (TRUS-Bx). The mean (range) follow-up was 32.7 (12-126) months. Disease reclassification occurred in 46 patients (40%). On univariate statistical analysis prostate specific antigen (PSA) (p = 0.05), prostate volume (PV) (p = 0.022), PSA density (PSAD) (p &lt; 0.001) and number of positive cores (p = 0.021) were significant factors for disease reclassification. On the multivariate analysis, PSAD (p &lt; 0.001) and PV (p = 0.003) were the only statistically significant independent variables to predict disease reclassification. A PSAD cut-off of 0.16 ng/ml² and a PV cut-off of 44 ml gave a maximal area under the curve, 0.69 and 0.63, respectively. Kaplan-Meier analysis showed that the median survival free from disease reclassification during AS was almost doubled in patients with PSAD &lt; 0.16 ng/ml2 or PV &gt; 44 ml. DCA showed a positive net benefit and clinical usefulness of the model, including PV, to predict disease reclassification between threshold probabilities of 20-50%.ConclusionsPV and PSAD significantly predicted failure from AS in our patients. Patients with a baseline PV of fewer than 44 ml would be more likely to have disease reclassification and unsuitable for acceptable AS protocols. Therefore, we believe that PV may help to select PCa patients for AS, especially in populations where the use of mpMRI is limited.
The Coronavirus pandemic and closed fitness clubs negatively affected members exercise habits
Authors: Gjestvang Christina , Tangen Elene Mauseth , Haakstad Lene A. H. 
Published: November 2022

IntroductionDue to the Coronavirus pandemic, politicians enacted directions to reduce social interactions, including lockdown of fitness clubs. We aimed to investigate how this changed exercise habits of Norwegian gym members.MethodBased on survey data, men and women (≥18 years, n = 233, data collection from Aug. 2020 to Jan. 2021) were recruited to this study by an email-invitation from their fitness club chain or by Facebook advertisement. The participants reported on background variables (e.g., age, gender, total household income, occupation, and education), and exercise habits pre- and during social lockdown. Data were analyzed using independent or student t-test, chi-squared test, or McNemar's test, as appropriate.ResultsHome-based exercise (18.0 vs. 72.5%, p = &lt;0.001), walking (49.8 vs. 65.2%, p = &lt;0.001), and cycling (16.7 vs. 24.5%, p = 0.004) was more common during than pre-lockdown. Also, men (4.33 to 3.68 days/week, p =0.013) and women (4.20 to 3.79 days/week, p = 0.001) reported a lower exercise frequency, and a shorter duration. Exercise frequency was lower in those with a BMI ≥25 than in those with BMI &lt;25 (3.95 vs. 4.48 days/week, p = &lt;0.007) pre-lockdown. High exercise attendees (≥3 sessions/week, 66.5%) reported a smaller decrease in exercise frequency (mean change: 0.06 vs. 1.24 days/week, p = &lt;0.001) and duration (&gt;60 min. per session: 33.0 vs. 3.8%, p = &lt;0.001) than low exercise attendees during lockdown.DiscussionHome-based exercise, walking, and cycling were most frequently reported during lockdown. Participants reported a small decrease in exercise duration and frequency compared with pre-lockdown. Closure of fitness clubs impacted low attendees more than high attendees.
Don't fear the (small) bite: A narrative review of the rationale and misconceptions surrounding closure of abdominal wall incisions
Authors: Theodorou Alexis , Banysch Mark , Gök Hakan , Deerenberg Eva B. , Kalff Joerg C. , von Websky Martin W. 
Published: November 2022

BackgroundThe most common complications related to the closure of abdominal wall incisions are surgical site infections, wound dehiscence and the development of an incisional hernia. Several factors relating to the surgical technique and the materials used have been identified and analysed over the years, as mirrored in the current recommendations of the European Hernia Society, but some misconceptions still remain that hinder wide implementation.MethodA literature search was performed in the PubMed and GoogleScholar databases on 15 July 2021 and additionally on 30 March 2022 to include recent updates. The goal was to describe the scientific background behind the optimal strategies for reducing incisional hernia risk after closure of abdominal wall incisions in a narrative style reviewResultsAn aponeurosis alone, small bites/small steps continuous suture technique should be used, using a slowly resorbable USP 2/0 or alternatively USP 0 suture loaded in a small ½ circle needle. The fascial edges should be properly visualised and tension should be moderate.ConclusionDespite the reproducibility, low risk and effectiveness in reducing wound complications following abdominal wall incisions, utilisation of the recommendation of the guidelines of the European Hernia Society remain relatively limited. More work is needed to clear misconceptions and disseminate the established knowledge and technique especially to younger surgeons