bluuebunny/crossref_metadata_2025_split huggingface dataset:
Production of Near-Isogenic Lines and Marked Monosomic Lines in Common Wheat (Triticum aestivum) cv. Chinese Spring
Authors: Tsujimoto H. 
Published: July 2002

AbstractSixteen near-isogenic lines (NILs) carrying a marker gene were produced by the recurrent backcrossing method in the genetic background of common wheat (Triticum aestivum) cv. Chinese Spring (CS). Three genes from alien species showed segregation distortion. In NILs carrying a marker gene of rye (Secale cereale) or Aegilops caudata, the alien chromosome segments were detected by fluorescence in situ hybridization (FISH). The NILs were grown with replications and the effect of marker genes on plant morphology in the genetic background of CS was investigated. These NILs were further crossed with the corresponding monosomics of CS and 13 monosomic lines whose monosome carries a respective marker gene were established and named “marked monosomics.” Many of the marked monosomics were distinguishable from the disomic NILs because of the different dosage effect of the genes. The NILs are utilized for studies on gene isolation or gene regulation. Marked monosomics are useful not only for monosomic analysis but also for production of homologous chromosome substitution lines because chromosome observation is not required.
Safety and Outcomes of a Plasmid DNA Vaccine Encoding the ERBB2 Intracellular Domain in Patients With Advanced-Stage ERBB2-Positive Breast Cancer
Authors: Disis Mary L. (Nora) , Guthrie Katherine A. , Liu Ying , Coveler Andrew L. , Higgins Doreen M. , Childs Jennifer S. , Dang Yushe , Salazar Lupe G. 
Published: November 2022

ImportanceHigh levels of ERBB2 (formerly HER2)–specific type 1 T cells in the peripheral blood are associated with favorable clinical outcomes after trastuzumab therapy; however, only a minority of patients develop measurable ERBB2 immunity after treatment. Vaccines designed to increase ERBB2-specific T-helper cells could induce ERBB2 immunity in a majority of patients.ObjectiveTo determine the safety and immunogenicity of 3 doses (10, 100, and 500 μg) of a plasmid-based vaccine encoding the ERBB2 intracellular domain (ICD).Design, Setting, and ParticipantsSingle-arm phase 1 trial including 66 patients with advanced-stage ERBB2-positive breast cancer treated in an academic medical center between 2001 and 2010 with 10-year postvaccine toxicity assessments. Data analysis was performed over 2 periods: January 2012 to March 2013 and July 2021 to August 2022.InterventionsPatients were sequentially enrolled to the 3 dose arms. The vaccine was administered intradermally once a month with soluble granulocyte-macrophage colony-stimulating factor as an adjuvant for 3 immunizations. Toxicity evaluations occurred at set intervals and yearly. Peripheral blood mononuclear cells were collected for evaluation of immunity. Biopsy of vaccine sites at weeks 16 and 36 measured DNA persistence.Main Outcomes and MeasuresSafety was graded by Common Terminology Criteria for Adverse Events, version 3.0, and ERBB2 ICD immune responses were measured by interferon-γ enzyme-linked immunosorbent spot. Secondary objectives determined if vaccine dose was associated with immunity and evaluated persistence of plasmid DNA at the vaccine site.ResultsA total of 66 patients (median [range] age, 51 [34-77] years) were enrolled. The majority of vaccine-related toxic effects were grade 1 and 2 and not significantly different between dose arms. Patients in arm 2 (100 μg) and arm 3 (500 μg) had higher magnitude ERBB2 ICD type 1 immune responses at most time points than arm 1 (10 μg) (arm 2 compared with arm 1, coefficient, 181 [95% CI, 60-303]; P = .003; arm 3 compared with arm 1, coefficient, 233 [95% CI, 102-363]; P &amp;lt; .001) after adjusting for baseline factors. ERBB2 ICD immunity at time points after the end of immunizations was significantly lower on average in patients with DNA persistence at week 16 compared with those without persistence. The highest vaccine dose was associated with the greatest incidence of persistent DNA at the injection site.Conclusions and RelevanceIn this phase 1 nonrandomized clinical trial, immunization with the 100-μg dose of the ERBB2 ICD plasmid-based vaccine was associated with generation of ERBB2-specific type 1 T cells in most patients with ERBB2-expressing breast cancer, and it is currently being evaluated in randomized phase 2 trials.Trial RegistrationClinicalTrials.gov Identifier: NCT00436254
Prevalence of Age-Related Macular Degeneration in the US in 2019
Authors: Rein David B. , Wittenborn John S , Burke-Conte Zeb , Gulia Rohit , Robalik Toshana , Ehrlich Joshua R. , Lundeen Elizabeth A. , Flaxman Abraham D. 
Published: November 2022

ImportanceAge-related macular degeneration (AMD) is a leading cause of vision loss and blindness. AMD prevalence has not been estimated for the US in over a decade and early-stage AMD prevalence estimates are scarce and inconsistently measured.ObjectiveTo produce estimates of early- and late-stage AMD prevalence overall and by age, gender, race and ethnicity, county, and state.Design, Setting, and ParticipantsThe study team conducted a bayesian meta-regression analysis of relevant data sources containing information on the prevalence of AMD among different population groups in the US.Data SourcesWe included data from the American Community Survey (2019), the National Health and Nutrition Examination Survey (2005-2008), US Centers for Medicare &amp;amp; Medicaid Services claims for fee-for-service beneficiaries (2018), and population-based studies (2004-2016).Study SelectionWe included all relevant data from the US Centers for Disease Control and Prevention’s Vision and Eye Health Surveillance System.Data Extraction and SynthesisThe prevalence of early- and late-stage AMD was estimated and stratified when possible by factors including county, age group, gender, and race and ethnicity. Data analysis occurred from June 2021 to April 2022.Main Outcomes or MeasuresThe prevalence of early- (defined as retinal pigment epithelium abnormalities or the presence of drusen 125 or more microns in diameter in either eye) and late-stage (defined as choroidal neovascularization and/or geographic atrophy in either eye) manifestations of AMD.ResultsThis study used data from nationally representative and local population-based studies that represent the populations in which they were conducted. For 2019, we estimated that there were 18.34 million people 40 years and older (95% uncertainty interval [UI], 15.30-22.03) living with early-stage AMD, corresponding to a crude prevalence rate of 11.64% (95% UI, 9.71-13.98). We estimated there were 1.49 million people 40 years and older (95% UI, 0.97-2.15) living with late-stage AMD, corresponding to a crude prevalence rate of 0.94% (95% UI, 0.62-1.36). Prevalence rates of early- and late-stage AMD varied by demographic characteristics and geography.Conclusions and RelevanceWe estimated a higher prevalence of early-stage AMD and a similar prevalence of late-stage AMD as compared with earlier studies. State-level and county-level AMD estimates may help guide public health practice.
Development and Psychometric Validation of the Taste And Smell Tool for Evaluation (TASTE) Questionnaire
Authors: Niklassen Andreas Steenholt , Christensen Karl Bang , Fjaeldstad Alexander Wieck , Ovesen Therese 
Published: November 2022

ImportanceThe human senses of taste and smell are essential in everyday life. However, as clinical testing of the senses and patient-reported sensory problems are often diverging, additional validated questionnaires are essential for the evaluation of chemosensory impairments.ObjectiveTo develop an instrument with all relevant domains concerning chemosensory dysfunction and quality of life using modern psychometrics.Design, Setting, and ParticipantsThe study was designed as a questionnaire study for developing a new instrument. The study started in 2019 and was completed in 2022. Patients with chemosensory dysfunction were recruited from a specialized smell and taste clinic at an ear, nose, and throat department in Denmark. Healthy participants with no history of chemosensory dysfunction were recruited through social media.Main Outcomes and MeasuresEight domains were included (distorted chemosensation, emotional, food and meals, social, hygiene, danger, work, and relationship), and 35 items were generated based on review of the existing literature and interviews with patients and experts. Participants were tested with the Major Depression Inventory, 36-Item Short Form Health Survey, Taste Sprays, and Sniffin’ Sticks for chemosensory function. Descriptive statistics were calculated for all items. Reliability, internal consistency, and validity were investigated, and a Rasch model was fitted. Healthy controls (n = 39) filled out the questionnaire for comparison of known-groups validity. Confirmatory factor analysis was performed. Finally, item reduction was performed, resulting in a final version with 21 items in 8 domains.ResultsThe study included responses from 316 patients, 183 women (58%) and 133 men (42%), with a mean (SD) age of 57 (15.1) years. Rasch model fit was acceptable with P &amp;gt; .05 for all items. An 8-dimensional confirmatory factor analysis model showed a better fit than a bifactor confirmatory factor analysis model. Cronbach α ranged from 0.65 to 0.86. Criterion validity with the Sniffin’ Sticks, Taste Sprays, Major Depression Inventory, and the 36-Item Short Form Health Survey was satisfactory. The test-retest reliability was good in all domains, ranging from 0.55 to 0.86. All domains were discriminative, except the social and work domains.Conclusions and RelevanceIn this survey study, the instrument was validated with 8 domains related to chemosensory dysfunction and quality of life. All items had good internal consistency, test-retest reliability, interitem correlations, item-total correlations, and Rasch model fit. The questionnaire appears suitable for use in clinical and research settings.
Photosensitive and Conductive Hydrogel Induced Innerved Bone Regeneration for Infected Bone Defect Repair
Authors: Jing Xirui , Xu Chao , Su Weijie , Ding Qiuyue , Ye Bing , Su Yanlin , Yu Keda , Zeng Lian , Yang Xu , Qu Yanzhen , Chen Kaifang , Sun Tingfang , Luo Zhiqiang , Guo Xiaodong 
Published: November 2022

AbstractRepairing infected bone defects is a challenge in the field of orthopedics because of the limited self‐healing capacity of bone tissue and the susceptibility of refractory materials to bacterial activity. Innervation is the initiating factor for bone regeneration and plays a key regulatory role in subsequent vascularization, ossification, and mineralization processes. Infection leads to necrosis of local nerve fibers, impeding the repair of infected bone defects. Herein, a biomaterial that can induce skeletal‐associated neural network reconstruction and bone regeneration with high antibacterial activity is proposed for the treatment of infected bone defects. A photosensitive conductive hydrogel is prepared by incorporating magnesium‐modified black phosphorus (BP@Mg) into gelatin methacrylate (GelMA). The near‐infrared irradiation‐based photothermal and photodynamic treatment of black phosphorus endows it with strong antibacterial activity, improving the inflammatory microenvironment and reducing bacteria‐induced bone tissue damage. The conductive nanosheets and bioactive ions released from BP@Mg synergistically improve the migration and secretion of Schwann cells, promote neurite outgrowth, and facilitate innerved bone regeneration. In an infected skull defect model, the GelMA‐BP@Mg hydrogel shows efficient antibacterial activity and promotes bone and CGRP+ nerve fiber regeneration. The phototherapy conductive hydrogel provides a novel strategy based on skeletal‐associated innervation for infected bone defect repair.
Merging the Interfaces of Different Shape‐Shifting Polymers Using Hybrid Exchange Reactions
Authors: Liang Huan , Zhang Shuai , Liu Yawen , Yang Yang , Zhang Yubai , Wu Yahe , Xu Hongtu , Wei Yen , Ji Yan 
Published: November 2022

AbstractSophisticated shape‐shifting structures and integration of advanced functions often call for different‐chemistry‐based polymers (such as epoxy and polyurethane) in a unified system. However, permanent cross‐links pose crucial obstacles to be seamless. Here, merging interfaces via hybrid exchange reactions among different dynamic covalent bonds (including ester, urethane, thiourethane, boronic–ester, and oxime–ester linkages) is proposed, breaking the long‐lasting restriction that these widely used bonds only undergo self‐exchange reactions. Model compound studies are conducted to verify that hybrid exchange reactions occur. As demonstrations, different liquid crystal elastomers are tenaciously joined into coherent assemblies, with the desired biomimetic structures (e.g., flying fish containing stiff and flexible parts) and rare deformation modes (e.g., flower blooming upon both heating and cooling). Besides connecting polymers, hybrid exchange reactions also facilitate the creation of new materials through cross‐fusion of different polymers. In addition to the polymers used in this work, hybrid exchange reactions can be adapted to other polymers based on similar mechanisms and beyond. Besides shape‐shifting‐related areas (e.g., soft robots, flexible electronics, and biomedical devices), it may also foster innovation in other fields involving general polymers, as well as promote deeper understanding of dynamic covalent chemistry.
Low‐Damping Spin‐Wave Transmission in YIG/Pt‐Interfaced Structures
Authors: Serha Rostyslav O. , Bozhko Dmytro A. , Agrawal Milan , Verba Roman V. , Kostylev Mikhail , Vasyuchka Vitaliy I. , Hillebrands Burkard , Serga Alexander A. 
Published: November 2022

AbstractMagnetic heterostructures consisting of single‐crystal yttrium iron garnet (YIG) films coated with platinum are widely used in spin‐wave experiments related to spintronic phenomena such as the spin‐transfer‐torque, spin‐Hall, and spin‐Seebeck effects. However, spin waves in YIG/Pt bilayers experience much stronger attenuation than in bare YIG films. For micrometer‐thick YIG films, this effect is caused by microwave eddy currents in the Pt layer. This paper reports that by employing an excitation configuration in which the YIG film faces the metal plate of the microstrip antenna structure, the eddy currents in Pt are shunted and the transmission of the Damon–Eschbach surface spin wave is greatly improved. The reduction in spin‐wave attenuation persists even when the Pt coating is separated from the ground plate by a thin dielectric layer. This makes the proposed excitation configuration suitable for injection of an electric current into the Pt layer and thus for application in spintronics devices. The theoretical analysis carried out within the framework of the electrodynamic approach reveals how the platinum nanolayer and the nearby highly conductive metal plate affect the group velocity and the lifetime of the Damon–Eshbach surface wave and how these two wavelength‐dependent quantities determine the transmission characteristics of the spin‐wave device.
Wettability Patternable Hybrid Polymer Films Based on TiO2 and Fluorinated Polymer for Bioelectronics Applications
Authors: Yamamoto Shunsuke , Kai Hiroyuki 
Published: November 2022

AbstractOrganic–inorganic hybrid films based on TiO2 and a fluorinated polymer are fabricated, and their properties are investigated for bioelectronic applications. The analysis revealed that the preparation process requires (1) aging the blend solution before spin coating and (2) spin coating under humid conditions to obtain hydrophobic honeycomb‐like surfaces. Ultraviolet (UV) irradiation changed the surface wettability to hydrophilic, and patterned irradiation resulted in hydrophobic‐hydrophilic surface patterns. Patterned hybrid films have been used as substrates in both open microfluidics and organic electrochemical transistor applications. This multimodal application will open up an integrated biosensing device that collects body fluids and analyzes them on a single platform.
Synthesis of tamarind seed gum‐based semi‐IPN hydrogels with integration of fertilizer retention and anti‐evaporation
Authors: Liu Xiaomei , Feng Tao , Ding Wenbin , Zeng Wei , Wang Na , Yang Fenghong , Yang Cailing , Yang Shenghua , Kong Yanrong , Lei Ziqiang 
Published: November 2022

AbstractIn this article, a tamarind seed gum‐g‐poly (acrylic acid‐co‐2‐Acrylamido‐2‐methyl‐1‐propane sulfonic acid/polyvinyl alcohol) (TSG‐g‐P[AA‐co‐AMPS/PVA]) was prepared by aqueous solution polymerization. The Fourier transform infrared spectroscopy, scanning electron microscopy, and thermogravimetric analysis were used to characterize. The swelling behaviors, reusability and water‐retention capabilities of hydrogels were evaluated. Under optimum synthesis conditions, the maximum equilibrium absorption of hydrogel was 1295 g·g−1, 208 g·g−1, 116 g·g−1 in deionized water, tap water and NaCl solution (0.9 wt%) respectively. Application of the hydrogel to soils increased their water‐holding and fertilizer retention capacities. Furthermore, the excellent water retention anti‐evaporation performance indicated that the hydrogel has the potential for applications in future sustainable agriculture and forestry.
Yunnan–Hong Kong wide field photometric survey
Authors: Gu Shenghong , Wang Xiaobin , Yeung Bill , Ng Eric , Yu Kamfung , Bai Jinming , Fan Yufeng , Sun Leilei , Xiang Yue , Cao Dongtao , Lun Baoli , Xin Yuxin , Wang Chuanjun , Xu Fukun , Liu Yisi 
Published: November 2022

AbstractWe are running a wide field photometric survey under the collaboration between Yunnan Observatories and Hong Kong Astronomical Society with a Centurion 18‐inch telescope at the Lijiang station of Yunnan Observatories, China. Its scientific goals are discovering new transiting exoplanetary systems and other types of variable stars, and studying asteroids of the solar system. The survey was designed to monitor several fixed sky areas through time series photometry with short cadences. Since 2016, numerous observing data have been accumulated and reduced by means of dedicated pipelines to deliver the light curves for tens of thousands objects, which are cross‐matched through the Carlsberg Meridian Catalog 15 or USNO‐B1.0 catalog. Systematic errors and trends that existed in the raw photometric results are simulated through selected reference stars and then removed to improve signal‐to‐noise ratios of the light curves, which is crucial to detect weak signals like exoplanet transits and other variable stars of low amplitudes in brightness variations. The final data products own the photometric precision better than 0.01 magnitude for stars brighter than 13.8 magnitude in the V band. By means of generalized Lomb–Scargle, phase dispersion minimization, and box‐fitting least squares techniques, we have already identified about a thousand of variable stars from the survey, including transiting exoplanet candidates, spotted stars, eclipsing binaries, pulsating stars, and so on. In addition, we have also captured around a thousand of asteroids of the solar system in the survey fields and produced their light curves due to spins.
Comparing the effects of static and dynamic signals during multiple schedules
Authors: Campos Claudia , Bloom Sarah E. , Kollin Lori , Weyman Jennifer R. 
Published: November 2022

AbstractThe extent to which multiple schedules are an effective schedule thinning method following functional communication training (FCT) relies on the control the schedule‐correlated stimuli exert over behavior. Thus, the stimuli used to signal the schedule in place (e.g., reinforcement and extinction) in a multiple schedule arrangement require special attention. To date, the majority of the research on multiple schedules has evaluated the use of different arbitrary signals as schedule‐correlated stimuli (e.g., poster boards). These signals are considered static as they lack movement. More recently, some studies have successfully used dynamic signals, which include movement or animation, within multiple schedule arrangements. However, the extent to which one type of signal may result in faster stimulus control over behavior has not been evaluated. Thus, the purpose of this study was to compare the use of static and dynamic signals as schedule‐correlated stimuli in multiple schedules used within the context of FCT. Four children diagnosed with autism spectrum disorder participated in the study. The results suggest that no differences in discriminated manding were observed for three out of four participants. Only dynamic signals resulted in discriminated manding for one participant.
A nonlinear relationship between corporate environmental performance and economic performance of green technology innovation: Moderating effect of government market‐based regulations
Authors: Wang Mingyue , Li Yingming , Wang Zitong 
Published: November 2022

AbstractGreen technology innovation corporates can effectively coordinate the relationship between the environment and the economy, which has been an area of interest among academia and governments. To stimulate the sustainable green technology innovation of corporates, it is necessary to clarify the internal correlation among green technology innovation, environmental performance, and economic performance. Based on the information of 642 industrial corporates obtained from a field investigation in China, this article systematically examines the relationships between corporate green technology innovation and environmental performance, economic performance, and the moderating effect of different governmental market‐based regulations on these relationships. The results show the following. (1) Green technology innovation can significantly improve corporate environmental performance and economic performance. (2) Corporate environmental performance can be transformed into economic performance, and an improvement in environmental performance leads to an increase in the economic performance produced by unit environmental performance, which shows a nonlinear relationship. (3) Government supply‐based market regulation negatively moderates the relationship between end‐of‐pipe technology innovation and environmental performance while positively moderating the relationship between green process innovation and environmental performance and the relationship between green product innovation and economic performance; government demand‐based market regulation positively moderates the relationship between green process innovation and environmental performance and the relationship between green process innovation and economic performance; government competitive‐based market regulation only has a positive effect on the relationship between green product innovation and economic performance. (4) Government market‐based regulations can positively promote the transformation from environmental performance to economic performance. The stronger the market‐based regulations, the greater the economic performance that corporate environmental performance can bring.