bluuebunny/crossref_metadata_2025_split huggingface dataset:
A ferroptosis-related gene signature and immune infiltration patterns predict the overall survival in acute myeloid leukemia patients
Authors: Yin Zhao , Li Fang , Zhou Qinjun , Zhu Jianfang , Liu Zhi , Huang Jing , Shen Huijuan , Ou Ruiming , Zhu Yangmin , Zhang Qing , Liu Shuang 
Published: August 2022

Targeted therapy for acute myeloid leukemia (AML) is an effective strategy, but currently, there are very limited therapeutic targets for AML treatment. Ferroptosis is strongly related to drug resistance and carcinogenesis. However, there are few reports about ferroptosis in AML. This article explores the relationship between ferroptosis-related gene (FRG) expression and prognosis in AML patients from the FerrDb and the Cancer Genome Atlas (TCGA) databases. The ferroptosis-related gene ARNTL was observed to have high expression and poor prognosis in AML. Receiver operating characteristic curve (ROC) analysis revealed the predictive accuracy of the signature. The area under the time-dependent ROC curve (AUC) was 0.533 at one year, 0.619 at two years, and 0.622 at three years within the training cohort. Moreover, we found that the ARNTL expression is closely associated with tumor-infiltrating immune cells like the macrophages and NK cells. Inhibiting the ARNTL expression suppressed colony formation and induced ferroptosis in AML cells. Overall, the survival prediction model constructed based on ARNTL accurately predicted the survival in AML patients, which could be a potential candidate for diagnosing and treating AML.
Primary Ewing’s sarcoma of sphenoid sinus: A case report and literature review
Authors: Wu Kunpeng , Zhu Xiaoyan , Li Yan , Wen Daxiong , Wu Huiyu , Lai Yanzhen , Li Yun , Wu Jian , Liu Zhuoxing 
Published: August 2022

BackgroundPrimary Ewing’s sarcoma of sphenoid sinus, observed in children and adolescents, is an extremely rare malignancy. Such rarity makes the imaging features and treatment strategies for Ewing’s sarcoma of sphenoid sinus unclear. This study aimed to offer guidance for treating this very disease by describing a patient with a rare primary Ewing’s sarcoma of sphenoid sinus and reviewing the available data in the literature.Case descriptionA case of Ewing’s sarcoma in sphenoid sinus treated with multidisciplinary treatment approaches, including tumor resection, radiotherapy, chemotherapy, and antiangiogenic therapy, was presented in this study. Moreover, literature for Ewing’s sarcoma in the head was systematically searched, and two cases in the sphenoid sinus and five cases in the sphenoid bone were identified. Furthermore, the clinical features, imaging findings, pathological characteristics, treatment, and prognosis were summarized.ConclusionTumor resection combined with radiotherapy and chemotherapy may provide favorable results for patients with Ewing’s sarcoma of sphenoid sinus and bone. However, more reports are still necessary to further clarify optimal management.
Partial vs. complete course of antenatal corticosteroid prophylaxis: An Italian single center retrospective study
Authors: Xodo Serena , Trombetta Giulia , Celante Lisa , Pittini Carla , Driul Lorenza , Cagnacci Angelo , Londero Ambrogio P. 
Published: August 2022

IntroductionThis study aimed to compare the outcomes of preterm infants given 12 vs. 24mg of betamethasone prophylaxis to understand whether a partial course of antenatal corticosteroids (CCS) could prevent or mitigate the major preterm birth complications.MethodsThis is a retrospective single-center cohort study including neonates born between 24 and 34 weeks of gestation from 2001 to 2019 at the University Hospital of Udine. The study population was divided into two groups: one group received 12mg, and another received a 24mg dose of betamethasone before the delivery. A separate analysis was performed for single and multiple pregnancies. The two groups were evaluated for various neonatal outcomes.ResultsThe study population included a total of 1,258 pregnancies and 1,543 neonates delivered between 24 and 34 weeks of gestation, of which 1,022 (803 single and 219 multiple pregnancies) were exposed to the complete CCS prophylaxis, whereas 236 (192 single and 44 multiple pregnancies) received the incomplete CCS prophylaxis. In single pregnancies, as for maternal characteristics, the most significant differences observed between the two groups are the following: a higher prevalence of spontaneous vaginal deliveries in the incomplete CCS prophylaxis (36.46 vs. 23.91%) and, by contrast, a higher prevalence of cesarean deliveries in the complete CCS prophylaxis group (75.72 vs. 63.02%). As for neonatal outcomes, the low Apgar score in the first and fifth min was significantly more prevalent in the incomplete CCS prophylaxis group compared with the complete CCS prophylaxis group. The group of incomplete CCS prophylaxis reported a higher occurrence of the following outcomes: IVH grade 3-4 (7.81 vs. 3.74%, p &lt; 0.05), PVL (7.29 vs. 1.99% p &lt; 0.05), ROP (23.96 vs. 18.06% p = 0.062), and RDS (84.38 vs. 78.83% p = 0.085). After adjusting for covariates, the complete CCS prophylaxis group in single pregnancies was significantly protective for IVH grade 3-4, PVL, and low Apgar's scores. Similar results were found in multiple pregnancies except for RDS.DiscussionThis retrospective single-center cohort study found that, compared with preterm infants treated with 24mg betamethasone in utero, those given half course of betamethasone had a significantly higher prevalence of IVH grade 3-4, PVL, RDS, and lower Apgar scores at 1 and 5 min. In conclusion, the evidence from this single-center retrospective study supports the preference for the complete CCS prophylaxis in women at risk of preterm birth because of its beneficial effect on the main adverse outcomes.
The prevalence and years lived with disability of asthma in children under 5 years old in Sichuan Southwest China, 1990–2019: A cross-sectional study
Authors: Luo Yu , Bao Li , Wang Mu , Guo Hui 
Published: August 2022

ObjectivesTo analyze the prevalence and Years Lived with Disability of Asthma in children under 5 years old and the time trends in Sichuan Southwest China from 1990–2019.MethodsBased on the results of the Global Burden of Disease Study 2019 (GBD2019), we present the time trend, sex specific prevalence, Years Lived with Disability (YLDs) and deaths due to asthma under 5 years old in Sichuan and compared them with national indicators in the same period.ResultsThe number of children under 5 years old with asthma decreased overall from 1990 to 2007 and increased overall from 2008 to 2019. The time trend of prevalence rate was similar. In 2019, over 111 thousands children under 5 years old suffered from asthma, the prevalence rate was 2,584 per 100 thousand, YLDs was 4.5 thousands, and YLDs rate was 105 per 100 thousand in Sichuan. Compared with 1990, the number of patients decreased by 48.6%, the prevalence increased by 9.4%, the YLDs decreased by 48.9%, and the YLDs rate increased by 9.7% in 2019. The increase in the prevalence and YLDs rate of asthma children in Sichuan was higher than the national overall, but the number of asthma deaths and deaths rate in Sichuan and the whole nation all decreased.ConclusionsThe results in Sichuan Southwest China show the prevalence and YLDs of asthma children under 5 years old increased over the past 30 years, and were higher than the overall increase in China. Male children are the key population of increasing asthma disease burden and deserves more attention. More targeted prevention and control measures are still needed to reduce the incidence of asthma.
Clinical implementation of plasma cell-free circulating tumor DNA quantification by digital droplet PCR for the monitoring of Ewing sarcoma in children and adolescents
Authors: Seidel Markus G. , Kashofer Karl , Moser Tina , Thueringer Andrea , Liegl-Atzwanger Bernadette , Leithner Andreas , Szkandera Joanna , Benesch Martin , El-Heliebi Amin , Heitzer Ellen 
Published: August 2022

BackgroundTreatment stratification and response assessment in pediatric sarcomas has relied on imaging studies and surgical/histopathological evidence of vital tumor cells. Such studies and evidence collection processes often involve radiation and/or general anesthesia in children. Cell-free circulating tumor DNA (ctDNA) detection in blood plasma is one available method of so-called liquid biopsies that has been shown to correlate qualitatively and quantitatively with the existence of vital tumor cells in the body. Our clinical observational study focused on the utility and feasibility of ctDNA detection in pediatric Ewing sarcoma (EWS) as a marker of minimal residual disease (MRD).Patients and methodsWe performed whole genome sequencing (WGS) to identify the exact breakpoints in tumors known to carry the EWS-FLI1 fusion gene. Patient-specific fusion breakpoints were tracked in peripheral blood plasma using digital droplet PCR (ddPCR) before, during, and after therapy in six children and young adults with EWS. Presence and levels of fusion breakpoints were correlated with clinical disease courses.ResultsWe show that the detection of ctDNA in the peripheral blood of EWS patients (i) is feasible in the clinical routine and (ii) allows for the longitudinal real-time monitoring of MRD activity in children and young adults. Although changing ctDNA levels correlated well with clinical outcome within patients, between patients, a high variability was observed (inter-individually).ConclusionctDNA detection by ddPCR is a highly sensitive, specific, feasible, and highly accurate method that can be applied in EWS for follow-up assessments as an additional surrogate parameter for clinical MRD monitoring and, potentially, also for treatment stratification in the near future.
Assessment of macular structures and vascular characteristics in highly myopic anisometropia using swept-source optical coherence tomography angiography
Authors: Wang Xin , Chen Yanhui , Wang Zhiyang , Li Haoru , He Qing , Rong Hua , Wei Ruihua 
Published: August 2022

Purpose: This study aimed to explore the macular structures and vascular characteristics of more myopic (MM) and contralateral eyes with highly myopic anisometropia.Methods: Comprehensive ophthalmic examinations were performed for 33 patients with highly myopic anisometropia. Macular structures (total retinal layer [TRL], ganglion cell and inner plexiform layer [GCIPL], inner nuclear layer [INL], outer retinal layer [ORL], nerve fiber layer [NFL], choroidal layer [CHL]) and vascular characteristics (superficial vascular complex density [SVD], deep vascular complex density [DVD], choriocapillaris perfusion area [CCPA]) were assessed using swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA). Macular structures and vascular characteristics of each subregion were compared to those of the Early Treatment of Diabetic Retinopathy Study (ETDRS).Results: With highly myopic anisometropia, the thicknesses of the TRL, GCIPL, INL, and ORL in MM eyes were smaller than those in contralateral eyes in at least one quadrant of the perifoveal and parafoveal circles (all p &lt; 0.05), with no changes in the foveal and temporal quadrants of perifoveal regions (all p &gt; 0.05). A thicker NFL (p = 0.018) was found in MM eyes than in contralateral eyes in the superior perifoveal quadrant. The CHL (all p &lt; 0.05) in MM eyes was thinner in all regions than in the contralateral eyes according to the ETDRS. There were no statistical differences in the SVD, DVD, and CCPA of MM and contralateral eyes (all p &gt; 0.05).Conclusion: All retinal layers, except the NFL, tended to be thinner in all subregions, except the temporal perifoveal and foveal quadrants in MM eyes, and choroidal thickness was thinned in all areas.
The effect of exercise on the prevention of gestational hypertension in obese and overweight pregnant women: An updated meta-analysis
Authors: Xie Enli , Tao Huimin , Liu Mengqing , Li Changchun , Zhao Qi 
Published: August 2022

BackgroundGestational hypertension (GH) is a common disease that seriously threatens the safety and health of pregnant women and their newborns. Physical exercise (PE) is widely recognized as a health maintenance method and it has numerous benefits. Studies on the association between PE and the risk of GH in obese and overweight pregnant women have generated controversial findings. This updated meta-analysis was performed to reassess the effects of PE on GH.MethodsThe articles from inception to April 2022, presenting studies investigating exercise intervention and pregnancy outcomes were explored across several online databases. Heterogeneity among the included studies was estimated and tested by Q test and I2 statistic. Risk ratios (RRs) and 95% confidence intervals (CI) were calculated through either random-effect or fixed-effect models. Subgroup analyses, sensitivity analyses, and publication bias diagnoses were also conducted.ResultsTwelve with 1,649 subjects were included. PE was associated with a reduced risk of GH in obese and overweight pregnant women (Pooled RR = 0.58, 95% CI = 0.42–0.81, P = 0.001; I2 = 24.3%). Subgroup analysis found significant trends amongst Eastern countries (RR = 0.59, 95% CI = 0.36–0.96, P = 0.033). Sensitivity analysis suggested the results were stable. No publication bias was detected based on Begg's test and Egger's test.ConclusionPE was associated with reduced risk of GH in obese and overweight pregnant women, especially in Eastern countries. More well-designed studies are still needed to further elaborate on these associations.Systematic review registrationCRD42022326183.
Risk factors for hidden blood loss in unilateral biportal endoscopic lumbar spine surgery
Authors: Guo Sijia , Tan Haining , Meng Hai , Li Xiang , Su Nan , Yu Linjia , Lin Jisheng , An Ning , Yang Yong , Fei Qi 
Published: August 2022

BackgroundUnilateral biportal endoscopic (UBE) spine surgery is a minimally invasive procedure for treating lumbar disorders. Hidden blood loss (HBL) is easily ignored by surgeons because blood loss is less visible. However, there are limited studies on HBL in UBE spine surgery. This study aimed to evaluate HBL and its possible risk factors in patients undergoing UBE spine surgery.MethodsPatients with lumbar disc herniation or lumbar spinal stenosis who underwent unilateral biportal endoscopic surgery between December 2020 and February 2022 at our hospital were retrospectively analyzed. Patient demographics, blood loss-related parameters, and surgical and radiological information were also collected. Pearson or Spearman correlation analysis was conducted to determine the association between clinical characteristics and HBL. Multivariate linear regression analysis was used to determine the independent risk factors for HBL.ResultsFifty-two patients (17 males and 35 females) were retrospectively enrolled in this study. The mean total blood loss (TBL) volume was 434 ± 212 ml, and the mean HBL volume was 361 ± 217 ml, accounting for 77.9% of the TBL in patients who underwent UBE surgery. Multivariate linear regression analysis revealed that HBL was positively associated with operation time (P = 0.040) and paraspinal muscle thickness at the target level (P = 0.033).ConclusionsThe amount of HBL in patients undergoing UBE surgery should not be neglected. Operation time and paraspinal muscle thickness at the target level may be independent risk factors for HBL.
Electoral Violence Impact on the Political Empowerment of Women in Jordan "Qualitative Study"
Authors: Al- Qaralleh Amir , Bader Ola , Al-Majali Wasan 
Published: August 2022

This study aims to identify electoral violence phenomenon against women and its impact on the political empowerment of Jordanian women. Additionally, it aims to reveal forms of violence to which Jordanian women are exposed as voters and candidates and the extent of Jordanian women’s awareness of electoral violence reporting mechanisms and proposals that help reduce this phenomenon. The study argued that electoral violence against women has its negative impact on their political empowerment and also breach basic women's rights. The study employed qualitative descriptive approach. Personal interviews were conducted to gather relevant data. The sample was taken in accordance with the purposive method. The sample consisted of (15) women who ran for political positions (Parliamentary, partisan and municipal) and (15) women as voters in the city of Amman for the period 2012-2020 . The most prominent results of the study are that (1) all respondents were exposed to one or more forms of violence whether as voters or candidates for the parliament, party or municipality; (2) they experienced violence during election period which was the most severe and harsh on them ; and (3)violence is not related to a certain gender as women participate in the practice of violence against women due to Jordanian cultural influence that is based on tribalism and that the most prominent sources of electoral violence against women are family and clan members. The study recommended communicating with international aid providers to establish links with local organizations to develop solemn strategies to combat gender-based electoral violence and integrating its topics into election period programs
المسؤولية الاجتماعية عند الإمام الجويني في كتابه "غياث الأمم في التياث الظلم" دراسة تأصيلية
Authors: هادي أبرار أحمد 
Published: August 2022

الأهداف: تهدف هذه الدراسة إلى بيان مفهوم المسؤولية الاجتماعية، وبيان أدوار المخاطبين بها، ثم استخراج نماذج تطبيقية تؤصل لها من كتاب الغياثي للإمام الجويني وبيان تكييفها الشرعي، وإثبات أن التراث الإسلامي قد عالج موضوع المسؤولية الاجتماعية منذ القدم، فهو ليس بالأمر المستحدث.
المنهجية: استخدم الباحث المنهج الوصفي التحليلي التأصيلي، وما يشمل من مناهج الاستقراء والاستنباط؛ وذلك لأنه يلائم محتوى الدراسة ويحقق أهدافها.
النتائج: وقد خلصت الدراسة إلى أن كتاب الغياثي يعد مرجعًا شاملًا من المراجع الأصيلة للمسؤولية الاجتماعية، وإلى أن حكم المسؤولية الاجتماعية هو الوجوب على كل الأمة، بما تشمله من حكام وعلماء وأغنياء وأفراد، كل بحسب حاله ومجاله وقدرته، فهي واجب ديني متأصل في الشريعة الإسلامية. وأن المظاهر والصور التأصيلية للمسؤولية الاجتماعية في الغياثي قد شملت كلًّا من البعد الديني والسياسي والاقتصادي والاجتماعي، وإن التكييف الفقهي لها قد تنوع بتنوع صورها، كما يجب على الأغنياء طاعة ولي الأمر بمشاركته في المسؤوليات الاجتماعية تجاه المجتمع حال الأزمات والعمل على مواجهتها وحلها، وجواز فرض الضريبة؛ فهي جزء من المسؤولية الاجتماعية التي تمثل واجبًا دينيًا ووطنيًا يعبر عن استدامة مقومات حركة الحياة.
التوصيات: يوصي الباحث بالاهتمام بالكتب التراثية التي تؤصل المسائل الواقعة والمستجدة في زماننا؛ فهي كثيرة ومتنوعة ومتعددة. كما يوصي الباحث أيضا بتعاون أبناء الشعب من الأغنياء مع الحكومات التي لم تفرض الضرائب لتحقيق المسؤولية الاجتماعية، ومعالجة الآثار السلبية للممارسات الاقتصادية الخاطئة خاصة مع جائحة كورونا.
The Quranic Concept of Economic Welfare
Authors: Gulzar Sadia 
Published: August 2022

Quran lays emphasis on the economic welfare of humanity. Allah Almighty decreed rulers work for the welfare of individuals. Muslims have been asked at many places in Holy Quran to help their needy poor fellow so that the people in society continue to help each other, class difference may not come into existence and no one in society is left needy. Quranic concept of economic welfare lays stress on that kind of economic prosperity in which the people of society are spiritually and mentally calm and satisfied. It educates individuals in a way that may help them succeed in both worlds. Quranic teachings on the circulation of wealth make welfare a phenomenon common to all classes of society, so that clashes between different classes of society may be avoided. A Muslim also purifies his soul from all kinds of impurities with the help of Infaq fi Sabil-il-Allah and may hope to seek the reward of this the hereafter. Allah Almighty commands to build the structure of economic growth on the foundation of best morals. Allah Almighty declares clearly in Holy Quran that nations or Individual would be punished when they violate His commands. To work for attaining worldly benefits, without violating the rules of Shariah is a collective as well as an individual responsibility. The purpose of this research paper is to highlight the importance of the Quranic concept of economic welfare in the present era. The research paper follows a descriptive and analytical approach.
ÖZEL YETENEKLİ OLAN VE ÖZEL YETENEK TANISI ALMAMIŞ ÖĞRENCİLERİN LİDERLİK POTANSİYELİNİN İNCELENMESİ
Authors: KAPLAN SAYI Ayşin , ATAMAN Semra , VATANARTIRAN Sinem 
Published: August 2022

Bu araştırmanın amacı, özel yetenekli olan ve özel yetenek tanısı almamış öğrencilerin liderlik potansiyelini incelemektir. Araştırma, tarama modelindedir. Araştırmanın örneklemini, 2018-2019 eğitim öğretim yılında İstanbul ilinde öğrenim gören 105 özel yetenekli, 287 özel yetenek tanısı almamış toplamda 392 öğrenci oluşturmaktadır. Çalışmada Liderlik Potansiyeli Ölçeği ve Demografik Bilgi Formu kullanılmıştır. Verilerin analizinde SPSS 21.0 programı kullanılmıştır. Analizler sonucunda; özel yetenekli olan öğrencilerin liderlik potansiyeli puanları özel yetenek tanısı almamış öğrencilerin liderlik potansiyeli puanlarından daha yüksek bulunmuştur. Liderlik potansiyeli puanlarının özel yetenekli olan ve özel yetenek tanısı almamış gruplarda yaşa, okul türüne ve anne eğitim durumuna göre farklılaştığı bulunurken; ailedeki çocuk sayısı, okul dışı faaliyete katılma, ekonomik durum değişkenleri açısından ise sadece özel yetenekli grupta farklılaştığı bulunmuştur. Diğer yandan liderlik potansiyeli puanlarının her iki grupta da cinsiyet değişkenine göre farklılaşmadığı bulunmuştur. Benzer araştırmalar farklı yaş grupları üzerinde ve liderlik eğitimleri verilerek etkilerini ölçmeye dönük yapılabilir.
* Bu makale, birinci yazar danışmanlığında yürütülen ve ikinci yazar tarafından “Üstün zekâlı olan ve olmayan çocukların liderlik potansiyelinin incelenmesi” isimli yüksek lisans tez çalışmasından üretilmiştir.
Competencias para el Desarrollo Sostenible ante la crisis planetaria
Authors: Jorge Zoraida 
Published: August 2022

Dada la actual emergencia planetaria que pone en peligro la sostenibilidad de las generaciones actuales y futuras es importante que los estudiantes sean formados desde el enfoque del paradigma socioformativo complejo y en competencias para el Desarrollo Sostenible que les permitan enfrentar los retos de insostenibilidad en el ejercicio de sus profesiones. En este artículo, se describe la importancia de la Educación para el Desarrollo Sostenible (EDS) y las competencias claves para la sostenibilidad que deben adquirir los educandos durante su prosecución académica y qué saberes debe manejar el profesorado para formar en dichas competencias. Los currículos de muchas universidades a nivel mundial se han transformado y organismos internaciones han impulsado proyectos de desarrollo a nivel de políticas públicas y educativas asociados a la sostenibilidad. Estas contribuciones abren las puertas a las reflexiones, debates y acciones que consoliden a la educación para el Desarrollo Sostenible como “motor de cambio”, ya que a través de ella se puede proporcionar a los ciudadanos las herramientas necesarias para consolidar los binomios que permiten mantener un mundo viable: crítica y creatividad, participación (inclusión) y democracia, gestión de conflictos y paz, respeto al medio ambiente y (bio)diversidad.