bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Forming Norbornene‐Tetrazine Hydrogels with Independently Tunable Properties
Authors: Gultian Kirstene A. , Gandhi Roshni , Kim Tae Won B. , Vega Sebastián L. 
Published: December 2022

AbstractAlthough photopolymerization reactions are commonly used to form hydrogels, these strategies rely on light and may not be suitable for delivering therapeutics in a minimally invasive manner. Here, hyaluronic acid (HA) macromers are modified with norbornene (Nor) or tetrazine (Tet) and upon mixing click into covalently crosslinked Nor‐Tet hydrogels via a Diels–Alder reaction. By incorporating a high degree of Nor and Tet substitution, Nor‐Tet hydrogels with a broad range in elastic moduli (5 to 30 kPa) and fast gelation times (1 to 5 min) are achieved. By pre‐coupling methacrylated HANor macromers with thiolated peptides via a Michael addition reaction, Nor‐Tet hydrogels are peptide‐functionalized without affecting their physical properties. Mesenchymal stem cells (MSCs) on RGD‐functionalized Nor‐Tet hydrogels adhere and exhibit stiffness‐dependent differences in matrix mechanosensing. Fluid properties of Nor‐Tet hydrogel solutions allow for injections through narrow syringe needles and can locally deliver viable cells and peptides. Substituting HA with enzymatically degradable gelatin also results in cell‐responsive Nor‐Tet hydrogels, and MSCs encapsulated in Nor‐Tet hydrogels preferentially differentiate into adipocytes or osteoblasts, based on 3D cellular spreading regulated by stable (HA) and degradable (gelatin) macromers.
Conjugated Polymers: Where We Come From, Where We Stand, and Where We Might Go
Authors: Müllen Klaus , Scherf Ullrich 
Published: December 2022

AbstractConjugated polymers (CPs) are electronic materials which always attract the joint attention of synthetic chemistry, physics, and engineering. The present article deals with “classical” CPs such as polyacetylenes and polyarylenes, and also with more sophisticated cases such as ladder polymers and graphene nanoribbons. CPs exhibit a wide variety of fascinating electrical and optical properties which qualify them as active components of devices. Their performance, however, is shown to sensitively depend upon structural perfection and purity as well as on the thin‐film morphology, which is also influenced by processing procedures. Nowadays, the need for innovative energy technologies and sustainable materials and processes as well as the emerging new opportunities of quantum technologies, are adding further momentum to CP research.
Efficient Fabrication of Carbon Nanotube‐Based Stretchable Electrodes for Flexible Electronic Devices
Authors: Gong Xiaofeng , Chu Zengyong , Li Guochen , Tan Yinlong , Dong Qichao , Hu Tianjiao , Zhao Zhenkai , Jiang Zhenhua 
Published: December 2022

AbstractStretchable electrodes are highly demanded in various wearable and flexible electronic devices, whereas the efficient fabrication approach is still a challenge. In this work, an efficient shrinking method to fabricate carbon nanotube (CNT)‐based stretchable electrodes is proposed. The electrode is a layer of anisotropic CNT wrinkling film coated on a latex balloon substrate (CNT@latex), whose resistivity remains stable after 25 000 stretching cycles of 0 to 50% tensile strain, and can survive up to 500% tensile train. The highly conductive electrode can be used as the current collector of a stretchable Zinc‐ion battery, maintaining an output voltage of 1.3 V during the stretching process of 0 to 100%. The applications of the electrode in flexible triboelectric nanogenerators and Joule heating devices are also demonstrated, further indicating their good prospects in the field of stretchable electronic devices.
Myotonic dystrophy type 1: A comparison between the adult‐ and late‐onset subtype
Authors: Joosten Isis B.T. , Horlings Corinne G. C. , Vosse Bettine A. H. , Wagner Anouk , Bovenkerk David S. H. , Evertz Reinder , Vernooy Kevin , van Engelen Baziel G. M. , Faber Catharina G. 
Published: December 2022

AbstractIntroduction/AimsAlthough the extent of muscle weakness and organ complications has not been well studied in patients with late‐onset myotonic dystrophy type 1 (DM1), adult‐onset DM1 is associated with severe muscle involvement and possible life‐threatening cardiac and respiratory complications. In this study we aimed to compare the clinical phenotype of adult‐onset vs late‐onset DM1, focusing on the prevalence of cardiac, respiratory, and muscular involvement.MethodsData were prospectively collected in the Dutch DM1 registry.ResultsTwo hundred seventy‐five adult‐onset and 66 late‐onset DM1 patients were included. Conduction delay on electrocardiogram was present in 123 of 275 (45%) adult‐onset patients, compared with 24 of 66 (36%) late‐onset patients (P= .218). DM1 subtype did not predict presence of conduction delay (odds ratio [OR] 0.706; confidence interval [CI] 0.405 to 1.230,P = .219). Subtype did predict indication for noninvasive ventilation (NIV) (late onset vs adult onset: OR, 0.254; CI, 0.104 to 0.617;P = .002) and 17% of late‐onset patients required NIV compared with 40% of adult‐onset patients. Muscular Impairment Rating Scale (MIRS) scores were significantly different between subtypes (MIRS 1 to 3 in 66% of adult onset vs 100% of late onset [P < .001]), as were DM1‐activCscores (67 ± 21 in adult onset vs 87 ± 15 in late onset;P < .001).DiscussionAlthough muscular phenotype was milder in late‐onset compared with adult‐onset DM1, the prevalence of conduction delay was comparable. Moreover, subtype was unable to predict the presence of cardiac conduction delay. Although adult‐onset patients had an increased risk of having an NIV indication, 17% of late‐onset patients required NIV. Despite different muscular phenotypes, screening for multiorgan involvement should be equally thorough in late‐onset as in adult‐onset DM1.
PARP inhibition promotes endothelial‐like traits in melanoma cells and modulates pericyte coverage dynamics during vasculogenic mimicry
Authors: Fernández‐Cortés Mónica , Delgado‐Bellido Daniel , Bermúdez‐Jiménez Eloísa , Paramio Jesús M , O'Valle Francisco , Vinckier Stefan , Carmeliet Peter , Garcia‐Diaz Angel , Oliver F Javier 
Published: December 2022

AbstractVasculogenic mimicry (VM) describes the ability of highly aggressive tumor cells to develop pseudovascular structures without the participation of endothelial cells. PARP1 is implicated in the activation of hypoxia‐inducible factors, which are crucial in tumor neovascularization. We have explored the role of hypoxia and PARP inhibition in VM. In uveal melanoma xenografts, the PARP inhibitor olaparib improved in vivo pericyte coverage specifically of VM channels. This was concomitant with reduced metastasis in olaparib‐treated VM+ tumors. PARP inhibition and hypoxia modulated melanoma tube formation in vitro, inducing a more sparse and regular tubular architecture. Whole‐transcriptome profiling revealed that olaparib treatment under hypoxic conditions modulated the expression of genes implicated in vasculogenesis during tube formation, enhancing the endothelial‐like phenotype of VM+ uveal melanoma cells. PARP inhibition, especially during hypoxia, upregulated PDGFβ, which is essential for pericyte recruitment. Our study indicates that PARP inhibitors may enhance the endothelial characteristics of VM+ cells, modulate pericyte coverage, and reduce metastatic spread in VM+ melanoma. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Myocd regulates airway smooth muscle cell remodeling in response to chronic asthmatic injury
Authors: Yang Qin , Miao Qing , Chen Hui , Li Duo , Luo Yongfeng , Chiu Joanne , Wang Hong‐Jun , Chuvanjyan Michael , Parmacek Michael S , Shi Wei 
Published: December 2022

AbstractAbnormal growth of airway smooth muscle cells is one of the key features in asthmatic airway remodeling, which is associated with asthma severity. The mechanisms underlying inappropriate airway smooth muscle cell growth in asthma remain largely unknown. Myocd has been reported to act as a key transcriptional coactivator in promoting airway‐specific smooth muscle development in fetal lungs. Whether Myocd controls airway smooth muscle remodeling in asthma has not been investigated. Mice with lung mesenchyme‐specific deletion of Myocd after lung development were generated, and a chronic asthma model was established by sensitizing and challenging the mice with ovalbumin for a prolonged period. Comparison of the asthmatic pathology between the Myocd knockout mice and the wild‐type controls revealed that abrogation of Myocd mitigated airway smooth muscle cell hypertrophy and hyperplasia, accompanied by reduced peri‐airway inflammation, decreased fibrillar collagen deposition on airway walls, and attenuation of abnormal mucin production in airway epithelial cells. Our study indicates that Myocd is a key transcriptional coactivator involved in asthma airway remodeling. Inhibition of Myocd in asthmatic airways may be an effective approach to breaking the vicious cycle of asthmatic progression, providing a novel strategy in treating severe and persistent asthma. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Genuinely Multipartite Entanglement Vias Shallow Quantum Circuits
Authors: Luo Ming‐Xing , Fei Shao‐Ming 
Published: December 2022

AbstractMultipartite entanglement is of important resources for quantum communication and quantum computation. The goal of this paper is to characterize general multipartite entangled states according to shallow quantum circuits. It is first proved that any genuinely multipartite entanglement on finite‐dimensional spaces can be generated by using 2‐layer shallow quantum circuit consisting of two biseparable quantum channels, which has the smallest nontrivial circuit depth in the shallow quantum circuit model. Further, a semi‐device‐independent entanglement model depending on the local connection ability in the second layer of quantum circuits is proposed. This implies a complete hierarchy of distinguishing genuinely multipartite entangled states. It shows a completely different multipartite nonlocality from the quantum network entanglement. These results show new insights for the multipartite entanglement, quantum network, and measurement‐based quantum computation.
Observation of room‐temperature out‐of‐plane switchable electric polarization in supported 3R‐MoS2 monolayers
Authors: Ma Li , Yang Liu , Fang Yuqiang , Xu Manzhang , Duan Ruihuan , Zhang Vanessa Li , Wang Xuewen , Huang Fuqiang , Wu Menghao , Liu Zheng , Yu Ting 
Published: December 2022

AbstractTwo‐dimensional (2D) ferroelectrics have attracted considerable attention due to their potential in the development of devices of miniaturization and multifunction. Although several van der Waals (vdW)‐layered materials show ferroelectricity, the experimental demonstrations of ferroelectric behavior in monolayers are very limited. Here we report the observation of room‐temperature out‐of‐plane switchable electric polarization in supported MoS2 monolayers exfoliated from 3R‐stacked bulk crystals under ambient conditions. Using in situ piezoelectric force microscopy and Kelvin probe force microscopy in a glovebox, we reveal that trapped water/ice molecules are responsible for this switchable electric polarization and this conclusion is strongly supported by theoretical simulations. It is worth noting that the water/ice trapping in the monolayers exfoliated from 2H‐stacked MoS2 crystals is not as much as that in 3R monolayers and, consequently, the out‐of‐plane electric polarization is missing there. Our findings indicate that monolayers with a trapped single layer of polar molecules might be emerging alternatives to 2D ferroelectrics. Furthermore, the stacking sequences may bring new properties and applications to 2D vdW materials not only when we stack them up but also when we thin them down.
Numerical study on structural performance of corrugated steel plate shear wall with different yield points steel
Authors: Li Gang , Wei Xing , Xiao Lin , Zhou Linjun 
Published: December 2022

SummaryAs a new type of lateral load‐resisting system in SPSW systems, corrugated SPSWs (CSPSWs) have been gradually researched and applied. Corrugated plates offer various advantages over flat plates including higher energy dissipation capacity, ductility, out‐of‐plane stiffness, and improved buckling stability. For seismic control and isolation techniques, low yield point (LYP) steels (LY100, LY160, and LY225) are the reliable and ideal energy‐dissipating materials. The low yield point CSPSWs combine high energy‐consuming materials with high‐performance structures to provide a better solution for ductile and seismic resistance of high‐rise and super tall buildings. Currently, there are no design codes addressing the seismic performance of LYP corrugated steel plate shear walls (CSPSWs). This study investigates cyclic behavior and energy dissipation performance of corrugated steel plate yield point (100, 160, 225, 235, and 345 MPa) of different thickness CSPSWs and determine the plate yield point that provides the optimum performance. Results and findings of this study reveal that compared with the ordinary yield strength corrugated steel plates, the low yield point CSPSWs have a larger safety factor of lateral bearing capacity, a fuller hysteresis curve, a strong energy dissipation coefficient, a larger ductility coefficient and a smaller fluctuation range of strength degradation coefficient, and better strength stability. The initial equivalent stiffness of CSPSWs with different yield strengths is the same.
Human globozoospermia‐related genes and their role in acrosome biogenesis
Authors: Moreno Ricardo D. 
Published: December 2022

AbstractThe mammalian acrosome is a secretory vesicle attached to the sperm nucleus whose fusion with the overlying plasma membrane is required to achieve fertilization. Acrosome biogenesis starts during meiosis, but it lasts through the entire process of haploid cell differentiation (spermiogenesis). Acrosome biogenesis is a stepwise process that involves membrane traffic from the Golgi apparatus, but it also seems that the lysosome/endosome system participates in this process. Defective sperm head morphology is accompanied by defective acrosome shape and function, and patients with these characteristics are infertile or subfertile. The most extreme case of acrosome biogenesis failure is globozoospermia syndrome, which is primarily characterized by the presence of round‐headed spermatozoa without acrosomes with cytoskeleton defects around the nucleus and infertility. Several genes participating in acrosome biogenesis have been uncovered using genetic deletions in mice, but only a few of them have been found to be deleted or modified in patients with globozoospermia. Understanding acrosome biogenesis is crucial to uncovering the molecular basis of male infertility and developing new diagnostic tools and assisted reproductive technologies that may help infertile patients through more effective treatment techniques.This article is categorized under:
Reproductive System Diseases > Environmental Factors
Infectious Diseases > Stem Cells and Development
Reproductive System Diseases > Molecular and Cellular Physiology
Loss of Reindeer Grazing Land in Finnmark, Norway, and Effects on Biodiversity: GLOBIO3 as Decision Support Tool at Arctic Local Level
Authors: van Rooij Wilbert , Aslaksen Iulie , Eira Isak Henrik , Burgess Philip , Garnåsjordet Per Arild 
Published: December 2022

AbstractCompeting land use and climate change are threats to the pasture land of Sámi reindeer herding. Reindeer pastures are exposed to the development of infrastructure, hydropower, mineral exploration, recreational cabin areas, and wind power. Land use conflicts are exacerbated under climate policy with wind power plants in reindeer herding areas. Projected developments and climate change impacts challenge the adaptive capacity of reindeer herders and the resilience of reindeer herding. Analysis of biodiversity loss by the GLOBIO3 model is suggested as tool for decision support, in consultation with Sámi reindeer owners, taking into account traditional knowledge of reindeer herding. GLOBIO3 analysis for Sámi reindeer herding land in Finnmark indicates that in 2011, compared to an intact situation, about 50% of the biodiversity of reindeer calving grounds has been lost, and it is expected to be reduced with another 10% in the scenario for 2030. Reindeer owners in Finnmark told that they expect biodiversity loss will have implications for the quality and extent of suitable grazing areas. Especially the quality of the calving grounds is essential for reindeer herding. An important lesson from dialogue with reindeer owners is that even highly impacted areas should not be considered as lost, and thus be opened to further development, as they are still important for seasonal reindeer migration and grazing at certain times of the year. The chapter presents research on methods development, traditional knowledge in the context of Sámi reindeer herders in Finnmark and highlights innovative tools to engage rightsholders and stakeholders in the Arctic in development planning processes.
Knowledge Graph Construction Research From Multi-source Vulnerability Intelligence
Authors: Du Lin , Xu Chuanqi 
Published: December 2022

AbstractThere is a huge Internet user group in China, and many enterprises and institutions are deeply affected by the threat of Cybersecurity vulnerabilities. At present, according to the needs of different business scenarios, relevant business personnel often need to search for different vulnerability information separately, relying on manpower, and the vulnerability intelligence distributed on the Internet has the characteristics of multi-source heterogeneity, which is difficult to ensure the effectiveness and reliability of vulnerability knowledge. In view of the above background, with vulnerabilities as the core, knowledge extraction of vulnerability intelligence is carried out according to existing standards, corresponding entities and relationships are established, and related and visualized knowledge graphs are studied and constructed to provide support for the discovery and traceability of vulnerability threats by information workers.
Anomaly matching across dimensions and supersymmetric Cardy formulae
Authors: Ohmori Kantaro , Tizzano Luigi 
Published: December 2022

Abstract
’t Hooft anomalies are known to induce specific contributions to the effective action at finite temperature. We present a general method to directly calculate such contributions from the anomaly polynomial of a given theory, including a term which involves a U(1) connection for the thermal circle isometry. Based on this observation, we show that the asymptotic behavior of the superconformal index of 4d$$ \mathcal{N} $$
N
= 1 theories on the “second sheet” can be calculated by integrating the anomaly polynomial on a particular background. The integration is then performed by an equivariant method to reproduce known results. Our method only depends on the anomaly polynomial and therefore the result is applicable to theories without known Lagrangian formulation. We also present a new formula that relates the behavior of 6d$$ \mathcal{N} $$
N
= (1, 0) SCFTs on the second sheet to the anomaly polynomial.
Diagnostik von Beinödemen
Authors: Stücker Markus , Protz Kerstin , Eder Stefan , Läuchli Severin , Traber Jürg , Dissemond Joachim 
Published: December 2022

ZusammenfassungÖdeme der unteren Extremitäten entsprechen immer einem pathologischen Zustand, der insbesondere bei Betroffenen mit chronischen Wunden einer Therapie bedarf. Weil die Ursachen dieser Ödeme sehr unterschiedlich und teilweise auch komplex sein können, sollte zuerst eine klinische und ggf. apparative Diagnostik erfolgen. Oft kann nach einer klinischen Untersuchung mit Testung des Stemmer- und Godet-Zeichens bereits eine klinische Verdachtsdiagnose gestellt werden. Als weiterführende apparative Diagnostik kann eine sonographische Untersuchung erfolgen. Messtechniken wie beispielsweise die Wasserplethysmographie gelten derzeit zwar als Goldstandard für Volumenmessungen, sind aber sehr aufwendig und fehleranfällig, sodass sie in der klinischen Routine heute kaum angewendet werden. Zusammenfassend wird empfohlen, für die Ödemdiagnostik eine klinische Untersuchung möglichst in Kombination mit einer Sonographie durchzuführen. Insbesondere zu Beginn der Entstauungsphase sollten regelmäßig Umfangsmessungen durchgeführt und dokumentiert werden. Diese Dokumentation ist für die Bewertung des therapeutischen Erfolgs von hoher Aussagekraft.
Some, but not all, patients experience full symptom resolution and a positive rehabilitation process after ACL reconstruction: an interview study
Authors: Piussi Ramana , Magnusson Cajsa , Andersson Sara , Mannerkorpi Kaisa , Thomeé Roland , Samuelsson Kristian , Hamrin Senorski Eric 
Published: December 2022

Abstract
Purpose
To gain a deeper understanding of patients’ experiences over 5 years after anterior cruciate ligament (ACL) reconstruction.

Methods
Seventeen semi-structured interviews were performed with patients treated with ACL reconstruction at least 5 years earlier without a second knee injury. Interviews were transcribed and analyzed using qualitative content analysis according to methods described by Graneheim and Lundman.

Results
Patients’ long-term experiences after an ACL reconstruction were summarized as: “to cope or not to cope, that is the question”, and five main categories: (1) Adapting life after knee symptom: the past will not come back; (2) An arduous and demanding rehabilitation: sailing against the wind; (3) Accepting what cannot be changed: biting the bullet; (4) Being satisfied with results: end of a chapter; (5) Apprehensively peregrinating on an unknown road.

Conclusions
More than 5 years after ACL reconstruction, patients can experience full symptom resolution and the ACL injury process as positive, or experience persistent symptoms and are forced to accept negative life-changing choices due to the injury.

Level of evidence
IV.
Critical exponents for a percolation model on transient graphs
Authors: Drewitz Alexander , Prévost Alexis , Rodriguez Pierre-François 
Published: December 2022

AbstractWe consider the bond percolation problem on a transient weighted graph induced by the excursion sets of the Gaussian free field on the corresponding cable system. Owing to the continuity of this setup and the strong Markov property of the field on the one hand, and the links with potential theory for the associated diffusion on the other, we rigorously determine the behavior of various key quantities related to the (near-)critical regime for this model. In particular, our results apply in case the base graph is the three-dimensional cubic lattice. They unveil the values of the associated critical exponents, which are explicit but not mean-field and consistent with predictions from scaling theory below the upper-critical dimension.