bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in mortality in septic patients according to the different organ failure during 13 years
Authors: Lorencio Carolina , Yébenes Juan Carlos , Vela Emili , Clèries Montserrat , Sirvent Josep Mª , Bertolín Cristina Fuster , Reina Clara , Rodríguez Alejandro , Ruiz-Rodríguez Juan Carlos , Trenado Josep , Torné Elisabeth Esteban 
Published: July 2022

Abstract
Background: the incidence of sepsis can be estimated between 250 and 500 cases/100.000 people per year and is responsible for up to 6% of total hospital admissions. Identified as one of the most relevant global health problems, sepsis is the condition that generates the highest costs in the healthcare system. Important changes in the management of septic patients have been included in recent years, however, there is no information about how changes in the management of sepsis-associated organ failure have contributed to mortality.Methods: A retrospective analysis was conducted from hospital discharge records from the Minimum Basic Data Set Acute-Care Hospitals (CMBD-HA in Catalan language) for the Catalan Health System (CatSalut). CMBD-HA is a mandatory population-based register of admissions to all public and private acute-care hospitals in Catalonia. Sepsis was defined by the presence of infection and at least one organ dysfunction. Patients hospitalized with sepsis were detected, according ICD-9-CM codes used to identify acute organ dysfunction and infectious processes.Results: Of 9.875.635 discharges from all acute-care hospitals during the study period (2005-2017), 254.627 had sepsis (2,58%). The mean annual sepsis incidence in the population was 245,5 per 100.000 inhabitants/year. Multiorgan failure was present in 20,3% and bacteremia in 29,1% of cases. Renal was the most frequent organ failure (55,9%), followed by cardiovascular (23,9%). Hospital mortality during the study period was 20,8%, but decreases continuously from 25,7% in 2005 to 16,5% in 2017 (p<0,0001) whereas rates of multiorgan failure and bacteraemia remains unchanged. The most important reduction in mortality was observed in cases with cardiovascular failure (from 47,3% in 2005 to 29,9% in 2017) (p<0,0001). In the same way, mean mortality related to respiratory and renal failure in sepsis was decreased in last years (p<0,0001). Conclusions: The incidence of sepsis has been increasing in recent years in our country. However, hospital mortality has been significantly reduced. In septic patients, all organ failures except liver have shown a statistically significant reduction on associated mortality, with cardiovascular failure as the most relevant.
Soluble E-cadherin: A marker of genital epithelial disruption
Authors: Liu R , Armstrong E , Mohammadi A , Galiwango RM , Buchanan LB , Constable S , Huibner S , Perry MC , Prodger JL , Coburn B , Kaul R 
Published: July 2022

Abstract
The genital epithelial barrier is a crucial first line of defence against HIV, and epithelial disruption may enhance HIV susceptibility. Assessment of genital epithelial integrity require biopsies, but their collection is not practical in many research settings. A validated biomarker of genital epithelial barrier integrity would therefore be useful. E-cadherin, an adhesion component of the cell-cell junction in epithelial tissues, may be released as soluble E-cadherin (sE-cad) upon epithelial trauma, and so we evaluated sE-cad as a marker of genital epithelial disruption. First, using an in vitro monolayer of immortalised endocervical epithelial cells, we demonstrate that sE-cad, IL-1β, and IL-1α levels are immediately increased after physical disruption, followed by a delayed increase in IL-6 levels compared to undisrupted controls. In vivo studies confirmed that sE-cad levels in cervicovaginal secretions were significantly elevated 6 hours after endocervical cytobrush sampling. Furthermore, the level of sE-cad in coronal sulcus swabs from Ugandan men was inversely correlated with the amount of membrane-bound E-cadherin within the overlying foreskin tissues. Our results validate the use of soluble E-cadherin as a marker of epithelial disruption and demonstrate that the processes of physical disruption and inflammation in the genital tract are strongly intertwined.
Evaluation of the prognostic factors for pediatric intestinal motility disorders: A single institution experience
Authors: Yano Keisuke , Muto Mitsuru , Sugita Koshiro , Murakami Masakazu , Onishi Shun , Harumatsu Toshio , Yamada Koji , Yamada Waka , Matsukubo Makoto , Kawano Takafumi , Kaji Tatsuru , Ieiri Satoshi 
Published: July 2022

Abstract
Purpose
To improve the life prognosis of patients with intestinal motility disorder (IMD), we explored predictors of survival.
Methods
We reviewed the medical records of IMD patients who required total parenteral nutrition (TPN) for four weeks or more at our institution from April 1984 to November 2021. We retrospectively evaluated the characteristics of patients with IMD as predictive factors.
Results
Fourteen patients were enrolled. They had high mortality rate (50%). The types of IMD were as follows: hypoganglionosis, extensive aganglionosis, and chronic idiopathic intestinal pseudo-obstruction. The mortality did not differ to a statistically significant extent among patients with three types of IMD. A significant difference was observed in the length of enterostomy between survivors and the non-survivors (p = 0.028). Cholestasis was a significant prognostic factor (p = 0.005). Intestinal failure associated liver disease (IFALD) was the cause of death in the short term. Catheter-related blood stream infection (CRBSI) and acute rejection after small bowel transplantation were causes of death in the long term.
Conclusion
IMD patients still have a high mortality rate and cholestasis predicts survival in IMD patients. Preventing or improving IFALD and CRBSI due to long-term TPN is important for reducing the mortality rate.
Real-life persistence of targeted therapy strategy in monotherapy versus combination therapy in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis
Authors: Exposito Lorena , Sánchez-Piedra Carlos , Vela-Casasempere Paloma , Moreno-Ramos Manuel José , Campos Cristina , Bohorquez Cristina , Manero Javier , Calvo-Gutiérrez Jerusalem , Rodríguez-Lozano Carlos , Ruiz-Montesino Dolores , Busquets Noemí , García-González Javier , Castrejón Isabel , Sanchez-Alonso Fernando , Bustabad Sagrario , Díaz-González Federico 
Published: July 2022

Abstract
Aim: To evaluate the persistence of the initial strategy of targeted therapy, with or without conventional synthetic (cs) disease-modifying antirheumatic drugs (DMARDs) (combination and monotherapy strategies, respectively) in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS), under real-life conditions. Methods: This is a nested cohort study within BIOBADASER III, a prospective Spanish registry of patients with rheumatic diseases who are undergoing treatment with targeted therapy including biologics (b) and targeted synthetic (ts) DMARDs. The primary outcome was to determine the initial treatment strategy persistence; switching drugs within the same class, but maintaining the initial strategy (combination or monotherapy) was considered persistence. Bivariate comparisons and multivariate Cox proportional hazard models were used for the analyses.Results: A total of 2,589 patients were included in our study. In the multivariate model, compared to monotherapy, the combination therapy strategy was associated with shorter persistence in patients with RA (hazard ratio [HR] 1.58, 95% confidence interval [CI] 1.00 to 2.50, p=0.049), PsA-Axial (HR 3.00, 95% CI 1.35 to 6.70, p=0.007), PsA-Peripheral (HR 2.58, 95% CI 1.51 to 4.39, p<0.001) and AS (HR 16.77, 95% CI 7.37 to 38.16, p<0.001). Overall, the combination strategy was associated with an increased incidence of any adverse event (incidence rate ratio [IRR] 1.13, 95% CI 1.05-1.21) but not of serious adverse events (1.02, 95% CI 0.84-1.24) compared to monotherapy,Conclusion: In this real-life study, compared to monotherapy, the strategy of combining a b/tsDMARD with a csDMARD at the start of treatment is associated with lower persistence and worse tolerability in RA, PsA and especially in AS, suggesting that combination therapy should be avoided in AS and possibly PsA patients and used cautiously in RA patients.
Cultivation of Osmundea pinnatifida (Hudson) Stackhouse in the Algem® Photobioreactor System
Authors: Biancacci Cecilia , McDougall Gordon J. , Day John G. , Stanley Michele S. 
Published: July 2022

Abstract
Cultivation of Osmundea pinnatifida (Hudson) Stackhouse in flasks and/or tanks has yet to be developed beyond the lab scale. However, establishment of a methodology for the supply of this red seaweed has great potential, considering that it can be exploited either as food or as a source of biologically active compounds with potential nutraceutical, pharmaceutical and cosmetic applications. This study investigates the possibility of growing O. pinnatifida in the Algem® photo bioreactor (PBR) system, normally utilised for microalgae cultivation, and examines the antioxidant content of the biomass. The cultures were incubated in the Algem® PBRs under a set of environmental parameters established in a previous seasonality study at a single location in the west of Scotland. The growth of the cultures in the PBR was monitored, the biomass assessed for antioxidant content, and results compared with seasonal samples, to assess how the PBR system affects the biochemistry of the species. Analyses centred on antioxidant activity and included Total Phenolic Content (TPC) and Ferric Iron Reducing Antioxidant Power (FRAP). A significant increase in the antioxidant content, two to five-time higher compared to wild samples, was achieved by cultivating the biomass in the PBR. This study highlights that the production of antioxidant compounds in O. pinnatifida can be improved by increasing photoperiod and light intensity and manipulating the wavelength. This information provides important insights into how cultivation conditions for this species can be tailored to increase production and improve the composition of the final product.
Comparison of frailty in patients with nontuberculous mycobacterial lung disease and bronchiectasis: a prospective cohort study
Authors: Fujita Kohei , Ito Yutaka , Yamamoto Yuki , Kanai Osamu , Imakita Takuma , Oi Issei , Ito Takanori , Saito Zentaro , Mio Tadashi 
Published: July 2022

Abstract
Background: The incidence of nontuberculous mycobacterial lung disease (NTM-LD) peaks in middle- and old age groups, coinciding with senescence; thus, chronic infectious diseases can accelerate frailty and worsen mental health in the elderly. In this study, we aimed to compare the prevalence of physical and psychiatric frailty between patients with NTM-LD and bronchiectasis (BE).Methods: The Kihon Checklist Questionnaire (KCQ) was used to assess physical and psychiatric frailties and identify those at risk of requiring care among patients with newly diagnosed NTM-LD and BE. Additionally, the Hospital Anxiety and Depression Scale (HADS) scores and chronic inflammatory biomarkers of the alveolar region (surfactant protein [SP]-A, SP-D, and human cationic antibacterial protein [hCAP]/LL-37) were assessed and compared between NTM-LD and BE patients.Results: There were no significant differences in the background characteristics between the 33 NTM and 36 BE patients recruited. The KCQ revealed that the proportion of frail NTM patients at diagnosis was higher than that of frail BE patients (48.5% vs. 22.2%, p=0.026). HADS scores were significantly higher in the NTM group than in the BE group (p<0.01). Bronchoalveolar lavage fluid (BALF) hCAP/LL-37 and SP-D levels were significantly higher (p=0.001), but serum hCAP/LL-37 levels were significantly lower in the NTM group than in the BE group (p=0.023). However, there were no significant differences in the BALF and serum SP-D levels between the two groups.Conclusions: The number of frail NTM patients at diagnosis was significantly higher than that of frail BE patients. Biomarker analysis suggested that the former had more localized lung inflammation than the latter.Trial registration: This trial was prospectively registered in the Clinical Trials Registry (UMIN 000027652).
Comprehensive study of anomalous hysteresis behavior in perovskite-based solar cells
Authors: Minbashi Mehran , Yazdani Elnaz 
Published: July 2022

Abstract
Perovskite solar cells (PSCs) have shown remarkable progress with the rapid increase in power conversion efficiency to reach 25.7% over the last few years. However, it is difficult to precisely determine the energy conversion efficiency for PSC, because of anomalous current density- voltage (J-V) hysteresis. Normal J-V hysteresis has been reported in many papers, where the backward scan (BS) performance is higher than the forward scan (FS) one. In this work, using Drift-Diffusion Modeling (DDM), normal hysteretic behavior associated with ion migration with different scanning rates, pre-bias voltages, and charge-carrier mobility is studied. In addition, the inverted J − V hysteresis by modification of the simulation model, where anions and cations flux towards the transport layers and are accumulated simultaneously on both sides, is achieved. It is also found that the flux parameter values (gae and gch) play a critical role in the reduction of inverted hysteresis and the efficiency enhancement. It is suggested from the current studies that perovskite interfaces encapsulation, which prevents ions migration, could be of great importance for achieving hysteresis-free PSCs and reliable device characteristics.
A rare case of well-differentiated liposarcoma with CDK4 amplification but without MDM2 amplification
Authors: Xu Dan , Wang Zhuo , Cao Huiping , Qiu Xueshan 
Published: July 2022

Abstract
Background: Well-differentiated liposarcoma (WDL)/atypical lipomatous tumor (ALT) and dedifferentiated liposarcoma (DDL) together comprise the largest subgroup of liposarcomas, and constitute up to 20% of all soft tissue sarcomas. WDL shares a common genetic feature characterized by high-level amplifications in the chromosome 12q13-15 region which contains the murine double minute-2 (MDM2), cyclin-dependent kinase-4 (CDK4) genes, and high mobility group protein AT-hook 2 (HMGA2). This is the first time we report a rare case of WDL with CDK4 amplification but without MDM2 amplification.Case presentation: A 61-year-old male presented with increased urine volume at night without fever, backache, abdominal distension, hematuria, urine pain, and other uncomfortable symptoms. Abdominal computed tomography revealed an uneven density, 6.6*6.3*6.1cm mass in the right renal inferior retroperitoneum. The patient was treated with the right retroperitoneal tumor resection. Light microscopy revealed a large number of necrotic areas, fibers separated into leaflets of varying size, fat-like cell sizes differences, with enlarged, deep stained, irregular nuclei, and scattered irregular spindle cells within the fiber septum. The MDM2 gene was not amplification by fluorescence in situ hybridization (FISH) which was considered the gold standard. A FISH assay with break-apart probes to detect DDIT3 gene rearrangement was negative. CDK4 gene amplification was detected by FISH. The diagnosis of the mass was WDL with CDK4 amplification but without MDM2 amplification. The patient was followed up for three months without symptoms and residual/recurrent tumors.Conclusions: WDL usually has MDM2, CDK4 gene amplification, and in some cases can have only MDM2 gene amplification without CDK4 gene amplification, but also note that this WDL with CDK4 amplification but no MDM2 amplification. Therefore, this case is of great significance to the clinical work of the pathologists.
A case report about infective endophthalmitis caused by Ochrobactrum anthropic after glaucoma and cataract surgery
Authors: zhu xiaomin , du qian , xiao minghe , lin qianyi , li xiangji , xie lin 
Published: July 2022

Abstract
Background: The aim of this study was to report an unusual case of infective endophthalmitis one week after Glaucoma and cataract surgery in her left eye. That caused by multidrug-resistant Ochrobactrum anthropic. Findings: Intravitreal fluid culture confirmed multidrug-resistant Ochrobactrum anthropic. Drug sensitivity indicated that it was sensitive to aminoglycosides, quinolones and imipenem. After two times of intravitreal and anterior chamber injection of moxifloxacin combined with imipenem, as well as intravenous and ocular medication, bacterial endophthalmitis was successfully relieved.Conclusions: The persistent and refractory multidrug-resistant Ochrobactrum anthropic endophthalmitis is a clinical rare entity, often due to indolent pathogens that water and Iatrogenic instruments, etc. Combined with vitreous fluid drug sensitivity test and related literature, A combination of intravitreal injection moxifloxacin and imipenem, as well as systemic intravenous therapy, eventually brought endophthalmitis under control and restored vision.
WITHDRAWN: Exploring Barriers to Dementia Screening and Management Services by General Practitioners in China: A qualitative study using the COM-B model
Authors: Yang Dan , Zou Jianfeng , He Qianyu , Hu Lei , Liao Jing , Gong Ni 
Published: July 2022

Abstract
Background
Dementia has become a global public health problem, and general practitioners (GPs) play a key role in the diagnosis and management of dementia. However, in Chinese primary care, dementia is under-diagnosed and inefficiently managed, and the dementia services provided by GPs are suboptimal. However, the reasons underlying this dementia service gap among GPs are poorly understood. This study aimed to determine the barriers that hinder GPs from actively promoting dementia services, and thereby provide insights for successful promotion of primary health care dementia services.
Methods
Group discussions and in-depth interviews were used for data collection. Inductive content analysis was used for data analysis, in combination with the Capability/Opportunity/Motivation-Behavior (COM-B) model as the framework for data analysis.
Results
Fifty-two GPs from the whole district of a city in southern China were included in this study. The COM-B model identified nine barriers: (1) capability: lack of systematic knowledge of dementia and difficulty in localizing and commissioning screening tools; (2) opportunity: insufficient time for dementia services, lack of dementia-specific leaders, unclear pathways for referral, no guarantee of service continuity; and (3) motivation: low sense of identity, psychological stress, and insufficient financial incentives.
Conclusions
The COM-B model could conceptually clarify the reasons underlying the suboptimal provision of dementia services by GPs in China. Under the influence of these barriers of capability, opportunity, and motivation, GPs not only failed to perform well in their role at the frontline of dementia prevention and treatment, but even had a sense of distrust in the practices they were expected to promote. Thus, standardization of the delivery of dementia services in primary care requires complex solutions, including standardized dementia training programs, standardized community-based dementia guidelines, expansion of primary care workforces, development of dedicated leaders, and universal dementia health education to bridge the gap between the expectations and reality of dementia services in primary care.
Proteome profiles of two Eucalyptus species during the early stage of somatic embryogenesis
Authors: Chen Bowen , Li Changrong , Chen Yingying , Chen Shengkan , Xiao Yufei , Wu Qi , Zhong Lianxiang , Huang Kaiyong 
Published: July 2022

Abstract
BackgroundEarly somatic embryogenesis (SE) has been recognized as an important tool for plants to propagate in vitro. However, our knowledge about the proteins involved in early SE including the callus dedifferentiation is still limited, especially in the economic woody tree – Eucalyptus.ResultsWe performed the data-independent acquisition (DIA) mass-spectrometry (MS) to study the proteins involved in early SE of two Eucalyptus species - E. camaldulensis (high regeneratively potential) and E. grandis x urophylla (low regenerative potential). Initially, the data-dependent acquisition MS produced 44,451 peptides and 9,142 proteins. While the DIA MS identified 35,207 peptides and 7,077 proteins in the stem and tissue-culture induced callus of the two Eucalyptus species. MSstat identified 2,078 and 2,807 differentially expressed proteins (DEPs) in early SE of E. camaldulensis and E. grandis x urophylla, respectively. They shared 760 upregulated and 420 downregulated proteins, including 4 transcription factors, 31 ribosomal proteins, 1 histone, 3 zinc finger proteins (ZFPs), ARF19, WOX8 and PIN1. Further, 27 and 4 DEPs were found to be involved in “photosynthesis” (ko00195) and “two-component system” (ko02020), respectively. Notably, SERK, WRKY, ZFP and ABC transporter proteins were analyzed to be related with high SE potential. By combining the miRNA and RNA-Seq results, some miRNA-mRNA/protein regulation networks might be involved in early SE of Eucalyptus, like miR160~TPP2, miR164~UXS2, miR169~COX11 and miR535~ Eucgr.E01067.ConclusionsThis is the first study of proteome profiles in early SE of Eucalyptus. The findings will improve our understanding of molecular changes and regulatory networks in early SE of Eucalyptus.
A novel group decision-making method for complex fuzzy information using extended power average operator and Frank operation
Authors: Xu Wuhuan , Yao Zhong , Wang Jun 
Published: July 2022

Abstract
The interval-valued q-rung dual hesitant fuzzy sets (IVq-RDHFSs) has been proposed for effectively representing complex fuzzy information. IVq-RDHFSs can describe the membership degree and non-membership degree respectively through interval value set, and can flexibly adjust the space of information expression, which makes them surpass most existing fuzzy sets. Nevertheless, the main shortage of the existing multi-attribute group decision making (MAGDM) methods based on IVq-RDHFSs is that the functions of operation rules and aggregation operators (AOs) are very limited. Therefore, this paper investigates a new MAGDM under IVq-RDHFSs, established on the powerful Frank t-norm and t-conorm (FTT) operation and extended power average (EPA) operator. With the help of FTT, the basic operation of IVq-RDHFSs is redefined, then the interval-valued q-rung dual hesitant fuzzy Frank extended power average operator and the interval-valued q-rung dual hesitant fuzzy Frank weighted extended power average (IVq-RDHFFWEPA) operator are developed by combining FTT and EPA. Likewise, the desirable properties and special cases of the new AOs are explored. Afterwards, a novel MAGDM framework is constructed on the foundation of IVq-RDHFFWEPA operator. Compared with most existing approach, the proposed MAGDM in this paper possesses prominent ability in controlling the effect of extreme evaluation as well as modeling the risk attitude of decision-makers, so it is more appropriate for practical application. Finally, diverse experiments are devised to analyze the use and advantages of our method.