bluuebunny/crossref_metadata_2025_split huggingface dataset:
YÜZELLİLİK NAMIK HİLMİ BEY’İN NOT DEFTERLERİNDE SÜRGÜN YILLARI
Authors: HALICI Şaduman 
Published: June 2022

Bu çalışmada Namık Hilmi’nin Mısır’dan Yunanistan’a uzanan ve yaşamının sonuna değin Yunanistan’da geçen sürgün yılları not defterleri temelinde ele alınacaktır. Bu çerçevede kurduğu dostlukları, dostları ile ilgili düşünceleri ve Kemalist Türkiye’ye bakışı incelenecektir.
Namık Hilmi’ye ait arşivimizde küçük boy dört not defteri bulunmaktadır. İlk defter 61 sayfa olup İstanbul’dan ayrılışından Kasım 1931’e kadar tuttuğu notları içermektedir. İkinci not defteri 9 Kasım 1931 günü başlamış, kimi kesintilerle 1935 Haziran ayı başına değin sürmüştür. 74 sayfadır ancak ilk üç sayfası boştur. 33 sayfadan oluşan üçüncü defter 5 Haziran 1935 günü başlamakta 28 Şubat1936’ya değin sürmektedir. Dördüncü ve son defter on sekiz sayfadan oluşmakta ve 29 Şubat – 26 Ekim 1936 tarihleri arasını kapsamaktadır.
Namık Hilmi’nin not defterleri siyasal/ideolojik bir tema üzerine kurgulanmamıştır. Daha çok günlük yaşama dair bilgiler not edilmiştir. Bu çerçevede yaptığı seyahatler, kurduğu dostluklar, kimlerle nerede, hangi yemekleri yiyip ne içtiğine dair olan bilgiler ayrıntılı olarak verilmiştir. Mali konular da oldukça detaylıdır. Bu çalışmada görüleceği gibi Namık Hilmi kimden ya da hangi kurumdan ne zaman ne kadar para aldığına dair bilgileri günü gününe not etmiştir. Harcamalarını da vermiştir. İlk iki defterde sıklıkla Şair Eşref’ten, Filozof Rıza Tevfik ve Baba Rıfıkı’dan dörtlüklere yer vermiştir. Kendisine ait şiirler de vardır ve imzasını Namık Hicri olarak atmıştır. Teması kadın ve çocuk olan şiirlerin pek çoğu oldukça müstehcendir. Bu nedenle çalışmada yer verilmeyecektir. Yine Kemalist Türkiye ve kurucuları ile ilgili yazdığı pek çok şiir de değerlendirilmeyecek ancak ruh halini ve düşünce dünyasını ortaya koyabilmek açısından ve ayıklanabildiği ölçüde örnek vermekle yetinilecektir.
Aplicabilidade dos bioestimuladores de colágeno (Ácido Poli-L-Lático e Hidroxiapatita de Cálcio) no preenchimento dérmico em áreas off-face do corpo
Authors: Nogueira Iago Cesar da Costa , Silva Natasha Cristina Silva da 
Published: June 2022

Este artigo tem como objetivo apresentar uma revisão integrativa de literatura, em que avalia as evidências clínicas da utilização dos bioestimuladores de colágeno para harmonização corporal e se há recomendação para a aplicação do produto, pois no contexto atual, os bioestimuladores atuam no rejuvenescimento corporal com o propósito de harmonizá-lo. Trata-se de um estudo feito através das bases de dados MEDLINE/PubMed e ScienceDirect, utilizando como Descritores em Ciências da Saúde (DeCS) em inglês e português: rejuvenescimento corporal, bioestimuladores corporais, preenchedores dérmicos corporais, contorno corporal, hidroxiapatita de cálcio, ácido poli-L-láctico e suas combinações, refinando os achados com o operador booleano AND. Levou-se em consideração um recordo temporal de 10 anos com publicações no período de 2012 a 2022, estudos clínicos nos quais possuíam no resumo informações que abarcassem o objetivo deste estudo. Os Estudos selecionados apresentam resultados satisfatórios com bioestimuladores em regiões off-face do corpo, sendo uma prática segura e eficaz para tratar flacidez e firmeza da pele, além de obter volumização e melhoria nos contornos corporais da pele. Embora os estudos ressaltem resultados promissores em áreas corporais, mais dados científicos são carecidos sobre o uso desses produtos nestas regiões.
Penyuluhan Internet Sehat Pada SMK Negeri 1 Tanjung Lubuk Kabupaten Ogan Komering Ilir (OKI) Sumatera Selatan
Authors: Agustina Merry , Widayati Qoriani , Rizal Syahril 
Published: June 2022

Seperti kita ketahui bahwa saat ini internet dapat dengan mudah diakses oleh setiap orang. Dengan internet dapat membawa orang ke mana saja hanya dengan satu klik. Namun karena kemudahan ini, dengan penggunaan internet yang tidak cermat dan tidak sehat pastinya dapat memberikan dampat negatif yang cukup besar. Remaja merupakan salah satu pengguna internet dengan semangat belajar dan rasa ingin tahu yang tinggi. Namun yang terjadi ada banyak penggunaan internet di kalangan remaja yang memberikan dampak negatif. Hal ini terjadi karena kurangnya pengetahuan remaja terhadap penggunaan yang baik dan cerdas atau penggunaan internet secara sehat. Kondisi ini terjadi dapat juga disebabkan kurangnya penjelasan dan edukasi terkait internet kepada para remaja. Oleh karena itu peran orang tua, guru dan masyarakat dalam membantu memberikan penjelasan, edukasi sebagai pemahaman kepada remaja tentang internet sangatla penting. Salah satu bentuk kegiatan edukasi tersebut adalah dengan dilakukannya Penyuluhan Internet Sehat Bagi para siswa. Karena dengan adanya kegiatan pengabdian berupa penyuluhan maka akan terjadi proses menjelaskan, memberika pemahaman dan tanya jawab tentang internet sehat, sehingga memberikan manfaat dengan meningkatnya pemahaman tentang internet sehat dan bijaksana sehingga meningkatnya dampat positif dan meminimalkan dampak negatif dari berinternet dan pada akhirnya tercipta remaja yang cerdas, kreatif dan produktif.
Pengembangan Kurikulum Merdeka Belajar Kampus Merdeka (MBKM) Program StudiPendidikan Olahraga Strata Satu (S1) Fakultas Keguruan Ilmu Pendidikan dan Bahasa Universitas Bina Darma
Authors: Endrawan I Bagus , Hardiyono Bayu , Satria M Haris , Kesumawati Selvi Atesya 
Published: June 2022

Pengabdian yang diberikan kepadamahasiswa khususnya pendidikan olahragainibertujuanuntukmemfasilitasi program studi untuk mengembangkan kurikulum sesuai dengan kebijakan MBKM dan mendorong program studi untuk melaksanakan kerja sama dengan mitra dalam rangka implementasi kurikulum program MBKM. Metode pelaksanaan dalamkegiatanpengabdianini adalah Focus Group Discusion (FGD) membahas mengenai pengenalan dan pelaksanaan Merdeka Belajar Kampus Merdeka (MBKM) di Universitas Bina Darma pada Program Studi Pendidikan Olahraga melalui aplikasi Zoom Meeting. Luaran yang diharapakan dalamkegiatanpengabdianini adalah:
(1) Dokumen laporan hasil penyusunan kurikulum program studi yang mendukung program MBKM termasuk prosedur konversi dan pengakuan kredit, (2) Publikasi di Jurnal Pengabdian KepadaMasyarakat.
Ishbāʿ al-maʿnā in the Qur’an: A Structural Survey of Sūrat al-Ḥāqqa (Q. 69)
Authors: ElShafey Mohamed Ibrahim 
Published: June 2022

This article seeks to define the meaning of the technical linguistic term ‘ ishbāʿ al-maʿnā’ (‘enhancing the meaning’) and explore how this device helps clarify the linguistic structure of Sūrat al-Ḥāqqa (Q. 69). The Qur’anic text, held to transcend time and space, utilises literary styles and lexical structures to convey its meaning across a diverse range of contexts. In this article the author analyses a selection of verses, all of which are characterised by the presence of ishbāʿ al-maʿnā. Sūrat al-Hāqqa offers a good sample of this category of verses. The primary research question will be approached via four enquiries and ten investigative points that offer both description and analysis of the occurrence of ishbāʿ al-maʿnā within Sūrat al-Ḥāqqa and the role linguistics plays in this phenomenon throughout the sura, which focuses primarily on the Day of Judgement.
FRCNet: Feature Refining and Context-Guided Network for Efficient Polyp Segmentation
Authors: Shi Liantao , Wang Yufeng , Li Zhengguo , Qiumiao Wen 
Published: June 2022

Colorectal cancer, also known as rectal cancer, is one of the most common forms of cancer, and it can be completely cured with early diagnosis. The most effective and objective method of screening and diagnosis is colonoscopy. Polyp segmentation plays a crucial role in the diagnosis and treatment of diseases related to the digestive system, providing doctors with detailed auxiliary boundary information during clinical analysis. To this end, we propose a novel light-weight feature refining and context-guided network (FRCNet) for real-time polyp segmentation. In this method, we first employed the enhanced context-calibrated module to extract the most discriminative features by developing long-range spatial dependence through a context-calibrated operation. This operation is helpful to alleviate the interference of background noise and effectively distinguish the target polyps from the background. Furthermore, we designed the progressive context-aware fusion module to dynamically capture multi-scale polyps by collecting multi-range context information. Finally, the multi-scale pyramid aggregation module was used to learn more representative features, and these features were fused to refine the segmented results. Extensive experiments on the Kvasir, ClinicDB, ColonDB, ETIS, and Endoscene datasets demonstrated the effectiveness of the proposed model. Specifically, FRCNet achieves an mIoU of 84.9% and mDice score of 91.5% on the Kvasir dataset with a model size of only 0.78 M parameters, outperforming state-of-the-art methods. Models and codes are available at the footnote.1
Intensifying Continuous Production of Gag-HA VLPs at High Cell Density Using Stable Insect Cells Adapted to Low Culture Temperature
Authors: Fernandes Bárbara , Correia Ricardo , Alves Paula M. , Roldão António 
Published: June 2022

Protein production processes based on stable insect cell lines require intensification to be competitive with the insect cell-baculovirus expression vector system (IC-BEVS). High cell density (HCD) cultures operate continuously, capable of maintaining specific production rates for extended periods of time which may lead to significant improvements in production yields. However, setting up such processes is challenging (e.g., selection of cell retention device and optimization of dilution rate), often demanding the manipulation of large volumes of culture medium with associated high cost. In this study, we developed a process for continuous production of Gag virus–like particles (VLP) pseudotyped with a model membrane protein (influenza hemagglutinin, HA) at HCD using stable insect cells adapted to low culture temperature. The impact of the cell retention device (ATF vs. TFF) and cell-specific perfusion rate (CSPR) on cell growth and protein expression kinetics was evaluated. Continuous production of Gag-HA VLPs was possible using both retention devices and CSPR of 0.04 nL/cell.d; TFF induces higher cell lysis when compared to ATF at later stages of the process (kD = 0.009 vs. 0.005 h−1, for TFF and ATF, respectively). Reducing CSPR to 0.01–0.02 nL/cell.d using ATF had a negligible impact on specific production rates (rHA = 72–68 titer/109 cell.h and rp24 = 12–11 pg/106 cell.h in all CSPR) and on particle morphology (round-shaped structures displaying HA spikes on their surface) and size distribution profile (peaks at approximately 100 nm). Notably, at these CSPRs, the amount of p24 or HA formed per volume of culture medium consumed per unit of process time increases by up to 3-fold when compared to batch and perfusion operation modes. Overall, this work demonstrates the potential of manipulating CSPRs to intensify the continuous production of Gag-HA VLPs at HCD using stable insect cells to make them an attractive alternative platform to IC-BEVS.
Why is Mortalin a Potential Therapeutic Target for Cancer?
Authors: Yoon A-Rum , Wadhwa Renu , Kaul Sunil C , Yun Chae-Ok 
Published: June 2022

Cancer is one of the leading causes of death worldwide, accounting for nearly 10 million deaths in 2020. Therefore, cancer therapy is a priority research field to explore the biology of the disease and identify novel targets for the development of better treatment strategies. Mortalin is a member of the heat shock 70 kDa protein family. It is enriched in several types of cancer and contributes to carcinogenesis in various ways, including inactivation of the tumor suppressor p53, deregulation of apoptosis, induction of epithelial–mesenchymal transition, and enhancement of cancer stemness. It has been studied extensively as a therapeutic target for cancer treatment, and several types of anti-mortalin molecules have been discovered that effectively suppress the tumor cell growth. In this review, we 1) provide a comprehensive sketch of the role of mortalin in tumor biology; 2) discuss various anti-mortalin molecules, including natural compounds, synthetic small molecules, peptides, antibodies, and nucleic acids, that have shown potential for cancer treatment in laboratory studies; and 3) provide future perspectives in cancer treatment.
Determination of Rare Earth Elements by Inductively Coupled Plasma–Tandem Quadrupole Mass Spectrometry With Nitrous Oxide as the Reaction Gas
Authors: Zhu Yanbei 
Published: June 2022

Nitrous oxide (N2O) was investigated as the reaction gas for the determination of rare earth elements (REEs) by inductively coupled plasma–tandem quadrupole mass spectrometry (ICP-QMS/QMS). The use of N2O as the reaction gas apparently improved the yields of mM16O+ for Eu and Yb in the reaction cell. As a result, the sensitivities for measurement of Eu and Yb were apparently improved in comparison to those obtained with O2 as the reaction gas. A high sensitivity measurement of the whole set of REEs was achieved, providing a typical sensitivity of 300,000 CPS mL/ng for REEs measured with an isotope having isotopic abundance close to 100%. The use of N2O as the reaction gas helped suppress Ba-related spectral interferences with the measurement of Eu, permitting the measurement of Eu in a natural sample without mathematic correction of spectral interferences. The detection limits (unit, pg/mL) for 14 REEs (except for Pm) from La to Lu were 0.028, 0.018, 0.006, 0.026, 0.006, 0.010, 0.017, 0.006, 0.016, 0.010, 0.016, 0.004, 0.023, and 0.012, respectively. The validity of the present method was confirmed by determining REEs in river water-certified reference materials, namely, SLRS-3 and SLRS-4.
Vertically-Ordered Mesoporous Silica Films for Electrochemical Detection of Hg(II) Ion in Pharmaceuticals and Soil Samples
Authors: Zhang Mengqi , Zou Yanqi , Zhou Xiaoyu , Yan Fei , Ding Zhanling 
Published: June 2022

Rapid and simple determination of mercury ion (Hg2+) in pharmaceuticals and soil samples is vital for human health and the environmental monitoring. Vertically-ordered mesoporous silica films (VMSF) supported by the indium tin oxide (ITO) electrode surface were prepared by electrochemically assisted self-assembly method and utilized for electrochemical detection of Hg2+. Owing to the negatively charged channel walls and ultrasmall pore diameter, VMSF displays obvious cationic selectivity and has highly electrostatic interaction for Hg2+, giving rise to the strong electrochemical signals. By recording the anodic stripping signals of adsorbed Hg2+ using differential pulse voltammetry, quantitative detection of Hg2+ was achieved with a wide linear range (0.2 μM–20 μM) and a low limit of detection (3 nM). Furthermore, considering the anti-fouling and anti-interference capacity of VMSF, the proposed VMSF/ITO sensor has been successfully applied to detect Hg2+ in pharmaceuticals and soil samples without tedious pretreatment processes of samples.
Identification of Key Non-coding RNAs and Transcription Factors in Calcific Aortic Valve Disease
Authors: Guo Shuai , Zhang Erli , Zhang Bin , Liu Qingrong , Meng Zhen , Li Ziang , Wang Can , Gong Zhaoting , Wu Yongjian 
Published: June 2022

BackgroundCalcific aortic valve disease (CAVD) is one of the most frequently occurring valvular heart diseases among the aging population. Currently, there is no known pharmacological treatment available to delay or reverse CAVD progression. The regulation of gene expression could contribute to the initiation, progression, and treatment of CAVD. Non-coding RNAs (ncRNAs) and transcription factors play essential regulatory roles in gene expression in CAVD; thus, further research is urgently needed.Materials and MethodsThe gene-expression profiles of GSE51472 and GSE12644 were obtained from the Gene Expression Omnibus database, and differentially expressed genes (DEGs) were identified in each dataset. A protein-protein-interaction (PPI) network of DEGs was then constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins database, and functional modules were analyzed with ClusterOne plugin in Cytoscape. Furthermore, Gene Ontology-functional annotation and Kyoto Encyclopedia of Genes and Genomes-pathway analysis were conducted for each functional module. Most crucially, ncRNAs and transcription factors acting on each functional module were separately identified using the RNAInter and TRRUST databases. The expression of predicted transcription factors and key genes was validated using GSE51472 and GSE12644. Furthermore, quantitative real-time PCR (qRT-PCR) experiments were performed to validate the differential expression of most promising candidates in human CAVD and control samples.ResultsAmong 552 DEGs, 383 were upregulated and 169 were downregulated. In the PPI network, 15 functional modules involving 182 genes and proteins were identified. After hypergeometric testing, 45 ncRNAs and 33 transcription factors were obtained. Among the predicted transcription factors, CIITA, HIF1A, JUN, POU2F2, and STAT6 were differentially expressed in both the training and validation sets. In addition, we found that key genes, namely, CD2, CD86, CXCL8, FCGR3B, GZMB, ITGB2, LY86, MMP9, PPBP, and TYROBP were also differentially expressed in both the training and validation sets. Among the most promising candidates, differential expressions of ETS1, JUN, NFKB1, RELA, SP1, STAT1, ANCR, and LOC101927497 were identified via qRT-PCR experiments.ConclusionIn this study, we identified functional modules with ncRNAs and transcription factors involved in CAVD pathogenesis. The current results suggest candidate molecules for further research on CAVD.
Can Dietary Nutrients Prevent Cancer Chemotherapy-Induced Cardiotoxicity? An Evidence Mapping of Human Studies and Animal Models
Authors: Zhang Xin-Yu , Yang Ke-Lu , Li Yang , Zhao Yang , Jiang Ke-Wei , Wang Quan , Liu Xiao-Nan 
Published: June 2022

IntroductionChemotherapy has significantly improved cancer survival rates at the cost of irreversible and frequent cardiovascular toxicity. As the main dose-dependent adverse effect, cardiotoxic effects not only limit the usage of chemotherapeutic agents, but also cause the high risk of severe poor prognoses for cancer survivors. Therefore, it is of great significance to seek more effective cardioprotective strategies. Some nutrients have been reported to diminish cardiac oxidative damage associated with chemotherapy. However, the currently available evidence is unclear, which requires a rigorous summary. As such, we conducted a systematic review of all available evidence and demonstrated whether nutrients derived from food could prevent cardiotoxicity caused by chemotherapy.MethodsWe searched Medline (via PubMed), Embase and the Cochrane Library from inception to Nov 9, 2021 to identify studies reporting dietary nutrients against cancer chemotherapy-related cardiotoxicity. We performed descriptive summaries on the included studies, and used forest plots to demonstrate the effects of various dietary nutrients.ResultsFifty-seven eligible studies were identified, involving 53 animal studies carried on rats or mice and four human studies in cancer patients. Seven types of dietary nutrients were recognized including polyphenols (mainly extracted from grapes, grape seeds, and tea), allicin (mainly extracted form garlic), lycopene (mainly extracted from tomatoes), polyunsaturated fatty acids, amino acids (mainly referring to glutamine), coenzyme Q10, and trace elements (mainly referring to zinc and selenium). Dietary nutrients ameliorated left ventricular dysfunctions and myocardial oxidative stress at varying degrees, which were caused by chemotherapy. The overall risk of bias of included studies was at moderate to high risk.ConclusionThe results indicated that dietary nutrients might be a potential strategy to protect cardiovascular system exposed to the chemotherapeutic agents, but more human studies are urged in this field.Systematic Review Registration:https://inplasy.com/inplasy-2022-3-0015/.
The Oral Microbiome and Its Role in Systemic Autoimmune Diseases: A Systematic Review of Big Data Analysis
Authors: Gao Lu , Cheng Zijian , Zhu Fudong , Bi Chunsheng , Shi Qiongling , Chen Xiaoyan 
Published: June 2022

IntroductionDespite decades of research, systemic autoimmune diseases (SADs) continue to be a major global health concern and the etiology of these diseases is still not clear. To date, with the development of high-throughput techniques, increasing evidence indicated a key role of oral microbiome in the pathogenesis of SADs, and the alterations of oral microbiome may contribute to the disease emergence or evolution. This review is to present the latest knowledge on the relationship between the oral microbiome and SADs, focusing on the multiomics data generated from a large set of samples.MethodologyBy searching the PubMed and Embase databases, studies that investigated the oral microbiome of SADs, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and Sjögren's syndrome (SS), were systematically reviewed according to the PRISMA guidelines.ResultsOne thousand and thirty-eight studies were found, and 25 studies were included: three referred to SLE, 12 referred to RA, nine referred to SS, and one to both SLE and SS. The 16S rRNA sequencing was the most frequent technique used. HOMD was the most common database aligned to and QIIME was the most popular pipeline for downstream analysis. Alterations in bacterial composition and population have been found in the oral samples of patients with SAD compared with the healthy controls. Results regarding candidate pathogens were not always in accordance, but Selenomonas and Veillonella were found significantly increased in three SADs, and Streptococcus was significantly decreased in the SADs compared with controls.ConclusionA large amount of sequencing data was collected from patients with SAD and controls in this systematic review. Oral microbial dysbiosis had been identified in these SADs, although the dysbiosis features were different among studies. There was a lack of standardized study methodology for each study from the inclusion criteria, sample type, sequencing platform, and referred database to downstream analysis pipeline and cutoff. Besides the genomics, transcriptomics, proteomics, and metabolomics technology should be used to investigate the oral microbiome of patients with SADs and also the at-risk individuals of disease development, which may provide us with a better understanding of the etiology of SADs and promote the development of the novel therapies.