bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pregnancy outcomes in pregnant women with diabetes treated with insulin alone and insulin with metformin
Authors: Elsaeed Usama Ahmed , Reda Ismail Riad  , Ahmed Taher  , Mahmoud Elnokeety  , Sherif  Elanwary  
Published: December 2022

Aim: The goal of this study was to compare maternal and neonatal results in diabetic pregnant ladies who were treated either insulin and metformin or insulin only.Methods: 220 pregnant diabetic women with type 1, 2 or gestational diabetes were randomisely assigned into two groups .each group is 110 pregnant diabetic women. One group takes insulin and metformin treatment to achieve glycemic targets and other take insulin only treatment. Pregnancy results in 110 ladies who stayed solely on insulin have been compared to pregnancy results in 110 pregnant diabetic ladies treated with insulin and metformin who were matching for age, weight, as well as ethnicity.Results: No significant variations in maternal risk factors existed at the start of the study. Group II from enrolling to term, they gained significantly more weight (5.90 vs. 4.39 kg; P < 0.000). When it came to gestational hypertension, there was no significant difference between groups I and II (14.5 against 19.1%, P = 0.367), pre-eclampsia (7.27 vs. 9.09%, P = 0.622),insulin dosage was decreased in group I statistically significant (mean 39.5±16.5 vs. 55.4±17.5 units, P= 0.000), vaginal delivery (41.8 vs. 47.3%, P = 0.416) or rate of elective Caesarean section (39.1 vs. 32.7%, P = 0.325), rate of emergency caesarean section (19.1 vs. 20%, P=0.865), perinatal loss (4 cases in group II vs. 3 cases in group I;P=0.701). Group I had a lower rate of neonatal morbidity; prematurity (16.63 vs. 24.55%, P = 0.417), neonatal hypoglycemia (7.3 vs. 24.5 %, P= 0.000), respiratory distress (13.64 vs. 30 %, P= 0.003), neonatal jaundice (13.6 vs. 33.6%, P < 0.000) and admittance to the newborn intensive care unit (24.55 vs. 35.45%, P = 0.077). Macrosomia occurrence (There was a significant difference in birth weight centiles > 90 [group I (16.4%) vs. group II (29.1%); P = 0.024]. The incidence of polyhydramnios was significantly different [group I (13.6%) vs. group II (32.7%); P = 0.001].Shoulder dystocia [group ? (2.7%) vs. group II (4.5%); P=0.721].Conclusions: Diabetic pregnant women who were treated with insulin plus metformin who had equal baseline risk factors for unfavourable pregnancy outcomes gained less weight and needed less insulin to maintain glycemic control. Furthermore improved neonatal outcomes as macrosomia, neonatal hypoglycemia, respiratory distress and special care baby admission compared with those treated with insulin alone.
Effectivity of uv-light exposure on bacterial and fungal growth in Channa striata collagen-chitosan composite dressing for wound healing
Authors: Andini Ary , Prayekti Endah , Kamaliyah Nur Indah , Halimah Nur 
Published: December 2022

Introduction: Channa striata collagen-chitosan wound dressing (3:1 v/v) was founded contaminate by bacterial and fungal. Therefore, to suppress bacterial and fungal contamination in Channa striata collagen-chitosan composite dressing, it needs several efforts such as sterilization under Ultra-Violet Light Exposure. The study aimed to determine UV-light exposure duration to supress bacterial and fungal growth on C. striata collagen-chitosan composite dressing.
Methods: C. striata collagen was extracted from skin and scales using 2% HCl for 48 hours, then neutralized using NaOH 1 M until collagen fibers appeared. Chitosan powder dissolved in 2% acetic acid. Afterward C. striata collagen and chitosan liquid (1:3 v/v) were mixed and formed until wound dressing was reached. Wound dressing was sterilized under UV exposure for 0, 5, 10, 15, and 30 minutes. Chitosan dressing was used as a negative control.
Results: The results of the study showed that the total number of bacteria and fungi decreased significantly with increasing time of exposure of UV light on composites dressing with a value of p=0.001 for bacterial growth and a value of p= 0.005 for fungus growth. The UV exposure on collagen-chitosan dressing to reduce bacterial and fungal growth proved effective in 10 minutes.
Conclusions: The UV light exposure treatment can reduce bacterial and fungal contamination on collagen-chitosan composites on each addition duration exposure descriptively.
Factors to accelerate the reducing stunting cases in Jombang regency, with optimal convergence actions and cross sectoral effort
Authors: Rizki Amalia  , Dini Setiarsih  , Fildzah Karunia Putri  , Paramita Viantry  
Published: December 2022

Introduction: The current burden of malnutrition in Indonesia is trifold. The nutrition programme component aims to reduce the triple burden of malnutrition throughout the life cycle, through support to maternal nutrition, prevention of stunting and wasting in children under 5 years of age, nutrition for school-age children and adolescents, and overweight prevention. The purpose of this study was to determine the factors to accelerate the reducing stunting cases in Jombang regency, with optimal convergence actions and cross sectoral effort.
Methods: This study is a qualitative study with a case study approach. The study is located in 11 village in Jombang regency. This study was conducted in September-November 2021. Data collection was carried out in in 11 village in Jombang district East Java Province, Curah Malang Village, Murukan Village, Diwek Village, Rejoslamet Village, Dukuh Klopo, Pakel, Kali Kejambon, Jombatan, Sumber Mulyo, Gadingmangu, Darurejo.
Results: The percentage of stunting in 2018 to 2021 has decreased significantly. According to data from the Bappeda of Jombang Regency on November 29, 2021, the stunting performance review activity showed that, in 2018 the number of cases in Jombang Regency was 20.1% with the number of stunting toddlers being 15,056 children, experiencing a decrease of 9.8% in 2021. The percentage of case data in 2021 is 10.3% with a total of 7,518 stunting children under five
Conclusion: The percentage of stunting in 2018 to 2021 has decreased significantly which is influenced by various factors that need to be controlled to reduce the incidence of stunting in Jombang regency.
Correlation of chest radiography of confirmed COVID-19 patients with comorbid hypertension and diabetes mellitus
Authors: Majdawati Ana , Annisa  
Published: December 2022

Introduction: Several studies showed 324 severe cases of COVID-19 and 1234 mild cases with the highest comorbidities of Hypertension, Diabetes Mellitus, Chronic Obstruvtives Pulmonary Disease (COPD), and Cardiovascular disease. These comorbid factors lead to a poor prognosis in COVID-19. Chest radiography is an important modality as one of the parameters that can indicate the severity of COVID-19. This study aims to determine the relationship between Covid-19, comorbid Hypertension, and Diabetes Mellitus with chest radiography.
Method: This research is analitic observational with cross-sectional, relationship between Covid-19 patients with comorbid Hypertension and Diabetes Mellitus with chest radiography (type, location, and extent of lesions) that Modified Chest X-Ray Scoring System in Evaluating Severity of COVID-19 Patient in Dr. Soetomo General Hospital Surabaya, Indonesia in 2021, COVID-19 radiology category. The data from PKU Muhammadiyah Gamping Hospital, Yogyakarta retrospectively from the medical records of Covid-19 patients who met the inclusion and exclusion criteria. Chi-Square analyzed the results variables with unpaired categorization.
Result: Most of the respondents who had comorbid diseases had moderate chest radiological features (65.4%) and those who did not have comorbid diseases had mild chest radiological features (71.9%), the results of chi-square data analysis between variables were p: 0.000.
Conclusion: The results of data analysis showed that comorbid diseases had a significant relationship with chest radiography in patients with confirmed COVID-19. The novelty of this study is the importance of radiological modalities as one of the parameters that can indicate the severity of Covid-19 patients with comorbidities.
Relationship between CYP2C19 polymorphisms and weight gain in epilepsy patients treated with divalproex sodium: does gender matter?
Authors: Islamiyah Wardah Rahmatul , Nasronudin  , Machin Abdulloh , Ernawati Iin , Sugianto Paulus 
Published: December 2022

Introduction: Epilepsy is an unprovoked seizure caused by an abnormal paroxysmal neuronal release in the brain. One of epilepsy treatments is anti-epileptic drug divalproex sodium. It is often prescribed to control seizures but it increases body weight. Weight gain may decrease the effectiveness of epilepsy treatment and cause endocrine disorders. CYP2C19 polymorphism may help physicians map patients vulnerable to weight gain due to divalproex sodium. This study aimed to determine the relationship between CYP2C19 polymorphisms and the incidence of weight gain based on gender in epilepsy patients treated with divalproex sodium.
Methods: This cross-sectional study consisted of 17 male and 23 female patients. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to identify CYP2C19 polymorphism which was grouped into: extensive metabolizer, intermediate metabolizer and poor metabolizer. The results were analyzed using Chi-squared test to determine the relationship between CYP2C19 and each variable (gender, age, epilepsy types, valproic acid types, family history of obesity and presence of weight gain) based on of gender.
Results: The results showed that there was no statistically significant association between CYP2C19 polymorphisms and gender-based epilepsy patients groups (p>0.05). We found that most of the subjects in this study were women with an increase in body weight by 57.5%. There was no association of CYP2C19 polymorphism with type of divalproex sodium, dose of divalproex sodium, length of treatment, type of epilepsy and family history of obesity.
Conclusion: There is no significant association between CYP2C19 polymorphism and weight gain between genders in epilepsy patients.
The description of pregnancy status and type of delivery attachment technique in postpartum mothers at the Roemani muhammadiyah hospital Semarang: assessed by latch score analysis
Authors: Machmudah  , Yunitasari Esti , Triharini Mira , Rejeki Sri 
Published: December 2022

Background: Breast milk plays a role in cognitive, sensory, and motor development and protects against infections and chronic diseases. The process of breastfeeding will protect the baby from illness, and increase cognitive intelligence and social-emotional development between mother and baby. Duration of breastfeeding was associated with acute illnesses, diarrhea, constipation, and a lower likelihood of being overweight/obese. Thus, this study aimed to the investigated correlation between pregnancy status and delivery type with successful breastfeeding in postpartum mothers at Roemani Muhammadiyah Hospital Semarang
Methods: This type of research was analytical descriptive, conducted in December 2021 with purposive sampling and a sample size of 120 respondents. The inclusion criteria of postpartum mothers who breastfeed their babies, mothers who are in good health, and baby who has no congenital abnormalities. Respondents who refused and who have babies with congenital abnormalities are excluded from the study. The data was extracted from the questionnaire and also coded into the SPSS 25 ver. Data were analyzed descriptively and analytically by using chi-square analysis.
Results: The participant with a planned pregnancy was 107 mothers (89.2%), unplanned 13 mothers (10,8%), section Caesarea type of delivery was 70 mothers (52%) and vaginal type of delivery was 50 mothers (48%). Based on LATCH score analysis planned pregnancy showed good category 38 mothers (31,7%), medium category 69 mothers (57,5%), and planned pregnancy showed good category 4 mothers (3,4%), medium category 8 mothers (6,7%), bad category 1 mother (0,8%). Based on the type of delivery, the vaginal type score was good for 25 mothers (50%), medium for 25 mothers (25%), and the section Caesarea type score was good for 17 mothers (24%), medium for 52 mothers (75%) and bad 1 mothers (1%). Either pregnancy status and type of delivery have P value scores of 0,016 and 0,012, respectively.
Conclusion: A mother that delivers a vaginal has a better level of breastfeeding than SC, and pregnancy status such as planned pregnancy also shows a better level than they are not.
Acute Erythroleukemia (AML-M6) in one-year-old boy: a case report
Authors: Prabawa I Putu Yuda , Mahartini Ni Nyoman , Herawati Sianny , Mulyantari Ni Kadek 
Published: December 2022

Background: Acute Erythroleukemia (AML-M6) is a rare case with approximately 3-4% of all Acute Myeloid Leukemia (AML) cases. AML-M6 is less common in the pediatric population, with an incidence of <1% of all pediatric leukemia cases. This case study aims to evaluate Acute Erythroleukemia (AML-M6) in a one-year-old boy at Prof. dr. IGNG Ngoerah Denpasar.
Case Presentation: A one-year-old boy with clinical manifestations of fluctuating fever for a month, paleness, bleeding gums, bruising all over his body, swelling of both eyelids and splenomegaly. Peripheral Blood Smear (PBS) examination revealed bicytopenia with moderate normochromic normocytic anemia, severe thrombocytopenia and leukocytosis. A hypercellular picture was obtained from the examination of Bone Marrow Aspiration (BMA) with an increase in erythroblast activity of 74%, proerythroblast at 50% and normal myeloblasts activity at 10%. The patient was diagnosed with Acute Erythroleukemia (AML-M6). The patient died on day 16 of treatment.
Conclusion: Based on the examination results, it was concluded that the patient was diagnosed with AML-M6 according to the PBS and BMA evaluation.
The pattern of osteocyte in dental socket bone regenerative induced by hydroxyapatite bovine tooth graft
Authors: Zubaidah Nanik , Kunarti Sri , Febrianti Nadira Nurin , Nurdianto Arif Rahman , Oktaria Wanda , Luthfi Muhammad 
Published: December 2022

Background: Tooth extraction is a procedure with the highest prevalence of causing alveolar bone damage. After extraction, the dimension will change. This procedure needs a balance of bone formation and resorption. Osteocytes are the most common cells in bone and have an essential role in bone formation. This study explores the effect of bovine tooth grafts on the number of osteocytes in the socket preservation process post-dental extraction.
Methods: A total of 28 Wistar rats, 14 control and 14 treatment groups, were extracted on the lower left incisor. Control group with PEG without induction and treatment group with bovine tooth graft and PEG induction. On the 14th and 28th days, the rats were euthanized. Then perform histological examination with HE staining and cell counting using a light microscope
Results: We found the treatment group had higher the average number of the osteocyte, which was 146.43±11.41 on 14th day and 288.14±161.91 on 28th day. There was a significant increase in osteocytes among the treatment group compared to the control (p=0.000).
Conclusion: Bovine tooth graft application as dental socket preservation was proven to increase the number of osteocyte cells in the alveolar bone of Wistar rats after extraction. Bovine tooth grafts as dental socket preservation materials increased the number of osteocytes at a peak at 28 days.
Perbedaan rasio neutrofil-limfosit terhadap lama rawat anak dengan pneumonia di Ruang Kaswari, RSUD Wangaya, Denpasar, Bali, Indonesia
Authors: Wasita I Kadek Serisana , Setiawan Putu Andrie , Suryawan I Wayan Bikin , Widiasa Anak Agung Made 
Published: December 2022

Background: Pneumonia is one of the most common causes of lower respiratory tract infections and ranked second to the cause of infant mortality (23.8%) and toddlers (15.5%) in Indonesia. The neutrophil-lymphocyte ratio (NLR) can be used as an indicator of the systemic inflammatory response due to pneumonia infection. This study aims to determine the difference in the value of RNL and the outcome of pediatric pneumonia.Methods: Analytical observational study with cross-sectional study design was conducted among 40 children with pneumonia who were admitted to the Kaswari Room at Wangaya Hospital in Denpasar City from January 2018 - March 2019 and fulfilled the inclusion criteria and exclusion criteria. The sample is determined by consecutive sampling. In this study, data regarding complete blood count were obtained from medical record register books (documentation). Data were analyzed using SPSS version 24 for Mac OSX.Result: There was no significant difference between patients with pneumonia who were hospitalized â‰¤ 4 days with those hospitalized> 4 days (P>0.05). Most of the samples were between 1 month to 1 year (62.5%) and more were male samples (55). There is a significant difference in the value of NLR (1.18 (0.07-13.83); p = 0.028) for the length of stay.Conclusion: There are significant differences in the value of the neutrophil-lymphocyte ratio in the length of stay of pediatric patients with pneumonia in the Kaswari room of Wangaya Hospital, Denpasar City.Â Latar Belakang: Pneumonia merupakan salah satu penyebab infeksi saluran napas bawah terbanyak menduduki peringkat kedua penyebab kematian bayi (23,8%) dan balita (15,5%) di Indonesia. Rasio neutrofil-limfosit (RNL) dapat digunakan sebagai salah satu indikator terhadap respon inflamasi sistemik akibat infeksi pneumonia. Penelitian ini bertujuan untuk mengetahui perbedaan nilai RNL pada luaran penyakit pneumonia anak.Metode: Penelitian observasional analitik dengan rancangan penelitian cross sectional dilakukan terhadap 40 pasien anak dengan pneumonia yang dirawat di Ruang Kaswari RSUD Wangaya Kota Denpasar sejak bulan Januari 2018 â€“ Maret 2019 serta memenuhi kriteria inklusi dan kriteria eksklusi Sampel ditentukan dengan cara consequtive sampling. Data tentang darah lengkap pada penelitian ini diperoleh dari buku register rekam medis (dokumentasi). Data dianalisis dengan SPSS versi 24 untuk Mac OSX.Hasil: Tidak terdapat perbedaan bermakna antara pasien pneumonia yang dirawat inap â‰¤ 4 hari dengan yang dirawat inap > 4 hari (P>0,05). Sebagian besar sampel berusia antara 1 bulan hingga 1 tahun (62,5%) dan lebih banyak yang sampel berjenis kelamin laki-laki (55). Terdapat perbedaan nilai RNL yang signifikan (1,18 (0,07-13,83); p=0,028) pada lama rawat inap.Simpulan: Â Terdapat perbedaan bermakna nilai rasio neutrofil-limfosit pada lama rawat pasien anak dengan pneumonia di ruang Kaswari RSUD Wangaya Kota Denpasar.
Diagnosis dan manajemen pada blefaritis anterior dan posterior
Authors: Utami Gusti Ayu Dian Listyani 
Published: December 2022

Introduction: Blepharitis is a chronic inflammatory condition of the eyelid margin. Blepharitis can be distinguished based on its location, namely anterior and posterior blepharitis. Anterior blepharitis is bilateral inflammation that occurs in the area around the base of the eyelashes and on the edge of the eyelid. Anterior blepharitis generally has two main types, namely, staphylococcal blepharitis and seborrheic blepharitis. Posterior blepharitis is inflammation of the eyelid on the posterior side due to dysfunction of the meibomian gland, chronic and bilateral.Aim: The aim of the study is to describe the comprehensive review regarding diagnosis and management of blepharitisConclusion: The general management used to relieve symptoms of blepharitis are warm compresses, cleaning the eyelids, including massage of the meibomian glands in cases of posterior blepharitis, antibiotic therapy (topically or systemically), topical anti-inflammatory, combination of antibiotics and topical corticosteroids, calcineuric inhibitor and Intensed Light Pulse (IPL) therapy. The treatment of blepharitis is done in combination to increase its effectiveness and get better treatment results. However, further research is still needed to select the regimen that has the highest efficacy and safety because blepharitis is a chronic disease with a high recurrence rate. Pendahuluan: Blefaritis merupakan peradangan yang bersifat kronis atau menahun dan pada umumnya berlokasi pada tepi kelopak mata. Blefaritis dapat dibedakan berdasarkan lokasinya yaitu blefaritis anterior dan posterior. Blefaritis anterior adalah peradangan bilateral yang terjadi di daerah sekitar dasar bulu mata dan pada tepi kelopak mata. Blefaritis anterior pada umumnya memiliki dua jenis utama yaitu, blefaritis stafilokokus dan blefaritis seboroik. Blefaritis posterior adalah peradangan kelopak mata pada bagian posterior akibat disfungsi dari kelenjar meibom, bersifat kronis dan bilateral.Tujuan: Tujuan dari tinjauan pustaka ini adalah untuk memberikan gambaran komperhensif akan diagnosis dan tatalaksanan dari bleparitis posterior.Simpulan: Manajemen umum yang gunakan untuk meringankan gejala blefaritis adalah kompres hangat, pembersihkan kelopak mata, termasuk didalamnya adalah pemijatan pada kelenjar meibom dalam kasus blefaritis posterior, terapi antibiotika (secara topical maupun sistemik), anti inflamasi topikal, kombinasi antibiotika dan kortikosteroid topikal dan calcineuric inhibitor serta intense light pulse therapy (IPL). Penanganan blefaritis dilakukan secara kombinasi untuk meningkatkan efektifitas dan mendapatkan hasil pengobatan yang lebih baik. Namun masih diperlukan penelitian lebih lanjut guna memilih regimen yang memiliki efikasi dan keamanan yang paling tinggi karena blefaritis merupakan penyakit kronis dengan tingkat kekambuhan yang tinggi.
Osteomielitis kronis yang terabaikan selama 15 tahun pada usia dewasa: laporan kasus
Authors: Yadnya I Putu Oka Buda , Kesuma Anak Agung Ngurah Ronny , Saputra I Komang Agus Krisna , Mendra I Komang Mahendra Laksana 
Published: December 2022

Background: Osteomyelitis has its challenges in its management. Not only because it requires time and cost in treatment, but also a collaboration between doctors, the patient and the environment of family and significant person to the patient himself to achieve optimal management.
Case Description: This report was conducted to find the therapy results in a patient with a diagnosis of chronic osteomyelitis, which has suffered the patient for 15 years. This study used a case reports study. Therapy given to the 29 years old male patient with a diagnosis of chronic osteomyelitis of the right femur Cierny Mader IVA was debridement and incision, as well as giving empirical antibiotics according to culture results. The result of the treatment was satisfactory.
Conclusion: The patient’s condition improved, and no complaints were reported. The patient can do activities with an assistive device.

Latar Belakang: Osteomielitis memiliki tantangan tersendiri dalam penatalaksanaanya, selain karena membutuhkan waktu dan biaya dalam pengobatan, dibutuhkan kerjasama antara dokter, pasien dan lingkungan baik itu keluarga ataupun orang terdekat pasien itu sendiri agar dapat mencapai penatalaksanaan yang optimal.
Deskripsi Kasus: Laporan ini bertujuan untuk mengetahui hasil pemberian terapi pada pasien dengan diagnosa osteomielitis kronis yang sudah diderita oleh pasien sejak 15 tahun yang lalu. Penelitian ini menggunakan metode laporan kasus. Terapi yang diberikan kepada pasien laki-laki 29 tahun dengan diagnosa osteomielitis kronis femur kanan cierny mader IVA berupa debridemen dan insisi, disertai pemberian antibiotik empirik sesuai hasil kultur. Hasil dari pemberian terapi tersebut cukup memuaskan.
Kesimpulan: Pasien mengalami perbaikan kondisi dan tidak didapatkan keluhan serta pasien dapat beraktifitas dengan alat bantu