bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated PERSEVERE and endothelial biomarker risk model predicts MODS in pediatric septic shock: A retrospective observational study
Authors: Atreya Mihir R. , Cvijanovich Natalie Z. , Fitzgerald Julie C. , Weiss Scott L. , Bigham Michael T. , Jain Parag N. , Schwarz Adam , Lutfi Riad , Nowak Jeffrey , Allen Geoffrey L. , Thomas Neal J. , Grunwell Jocelyn R. , Baines Torrey , Quasney Michael , Haileselassie Bereketeab , Lindsell Christopher J. , Alder Matthew N. , Wong Hector R. 
Published: May 2022

Abstract
Background: Multiple organ dysfunction syndrome (MODS) is a critical driver of sepsis morbidity and mortality in children. Early identification of those at risk of persistent organ dysfunctions is necessary to enrich patients for future trials of sepsis therapeutics. Here, we sought to integrate endothelial and PERSEVERE biomarkers to estimate risk of day 7 MODS and individual organ dysfunctions on day 7 of pediatric septic shock.Methods: We measured endothelial dysfunction markers from day 1 serum among those with existing PERSEVERE data. TreeNet® classification model was derived incorporating 22 clinical and biological variables to estimate risk. Based on relative variable importance, a simplified 6 biomarker model was developed thereafter. Results: Among 502 patients, 173 (34.5%) patients had MODS on day 7. Area under the receiver operator characteristic curve (AUROC) for the newly derived PERSEVEREnce model to predict day 7 MODS was 0.93 (0.91-0.95) with a summary AUROC of 0.80 (0.76-0.84) upon 10-fold cross validation. The simplified model, based on IL-8, HSP70, ICAM-1, Angpt2/Tie2, Angpt2/Angpt1, and Thrombomodulin performed similarly. Interaction between variables – ICAM-1 with IL-8 and Thrombomodulin with Angpt2/Angpt1 contributed to the models’ predictive capabilities. Model performance varied when estimating risk of individual organ dysfunctions with AUROCS ranging between 0.91 to 0.97 and 0.68 to 0.89 in training and test sets respectively. Conclusions: The newly derived PERSEVEREnce biomarker model reliably estimates risk of day 7 MODS and individual organ dysfunctions in pediatric septic shock. If validated, this tool can be used for prognostic enrichment in future pediatric trials of sepsis therapeutics.
Sleep analysis results of portable polysomnography in patients with acute and chronic temporomandibular disorder
Authors: Lee Yeon-Hee , Auh Q-Schick 
Published: May 2022

Abstract
Objective: This study aimed to investigate portable polysomnography (PSG)-based 'sleep' and pre-diagnosis of obstructive sleep apnoea (OSA) in acute temporomandibular disorder (TMD) and patients with chronic TMD.Methods: Randomly selected 25 patients with acute TMD (mean age, 42.58 ± 18.77 years; 14 females) and 26 age-and sex-matched patients with chronic TMD (mean age, 49.24 ± 17.52 years, 19 females) were enrolled.Results: The eight psychological subscales of SCL-90R had significantly higher values in the chronic TMD group than in the acute TMD group (all p < 0.05). There was no significant group difference in the respiratory event index examined using a portable PSG. OSA was observed in 57.7% in acute TMD, and 68.0% in chronic TMD, respectively. From the multiple regression analysis, palpation index was the strongest predictor of pre-diagnosis of OSA (OR = 17.550). Among the contributing factors for TMD, psychological stress (OR = 12.226), self-reported sleep problems (OR = 10.222), and above-average value of DEP (OR = 1.443) were followed.Conclusion: Patients with chronic TMD were psychologically more vulnerable than those with acute TMD, and the existence of subjectively perceived sleep problems or objective sleep indices examined by portable PSG could affect TMD symptom severity in different ways.
Multiobjective Deep Reinforcement Learning based Joint Beamforming and Power Allocation in UAV assisted Cellular Communication
Authors: Li Haitao , lv xin , Zhang Shuai 
Published: May 2022

Abstract
In order to provide spectrum and energy efficient communication for unmanned aerial vehicle (UAV) assisted cellular network, the problem of joint beamforming and power allocation (JBPA) in aerial multicell scenario is addressed. The JBPA multiobjective optimization model which would simultaneously maximize the achievable spectrum and energy efficiency is first developed. In view of the model, the centralized deep reinforcement learning (DRL) algorithm, i.e., upper confidence bound based Dueling deep Q network (UCB DDQN) with Mish activation function, is proposed to solve the multiobjective optimization problem and we make use of this learning algorithm to design joint beamforming and power allocation strategy. Furthermore, a federated UCB DDQN learning based JBPA is to proposed tackle the challenge of centralized DRL would require excessive data exchange. Simulation results validate that the faster convergence speed and the total weighted energy-spectrum efficiency (TWESE) achieved by the joint beamforming and power allocation based on UCB DDQN is greater than conventional DQN based resource allocation approach, and show the superior TWESE performance federated UCB DDQN achieve compared to centralized UCB DDQN.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) ­and­ influenza­ virus coinfection during the COVID-19 pandemic
Authors: Ansari Nastaran , Bakhtiari Somaye , Doosti-Irani Amin , Asadi Fatemeh Torkaman 
Published: May 2022

Abstract
In covid-19 patients, undetected coinfection may have seriously increased hospitalization, a variety of therapeutic approaches, and mortality; therefore, we examined the proportion of SARS-CoV-2 and influenza virus coinfection among referred cases-patients from November to January 2021 in Hamedan province, Iran. Nasopharyngeal and oropharyngeal samples were obtained from 14116 individuals with COVID-19 symptoms (2216 inpatient and 11903 outpatient) and they screened for respiratory pathogens (SARS-CoV-2 and influenza virus) using multiplex real-time PCR panel assay. Case-patients were with a < = 18, 19–60 and 60 < = age, and 53.56% and 46.44% were male and female, respectively. Among them, 2004 (14.19%) were infected with the influenza virus; 2409 (17.11%) were infected with the SARS-CoV-2, and 191 (1.35%) were co-infected with both viruses. Patients aged 19–60 were more likely to be infected with a coinfection. Also, coinfection 96(50.26) was more common in females than males. The positive and negative cases reported for SARS-CoV-2, influenza virus, and coinfection were more observed in Hamedan city. Our result suggests that the circulating influenza virus was during the COVID-19 pandemic during the peak season, but coinfection with SARS-CoV-2 and influenza virus was not very common.
Modeling of two-scale array microstructure and prediction of apparent contact angle based on WEDM
Authors: Li Zhaolong , Liu Yingtao , Li Wangwang , Cao Bingren , Dai Ye 
Published: May 2022

Abstract
The core issue in the theoretical design of superhydrophobic surfaces is to elucidate the relationship between surface microstructure and wettability. In this paper, four two-scale array microstructure models with different shapes are proposed to predict the apparent contact angles (CAs) of EN-GJL-250 (Grey Cast Iron) surface under different Wire-cut electrical discharge machining (WEDM) discharge parameters. The primary microstructure is the artificially designed semicircle, rectangular, sawtooth and square column array microstructure, and the secondary microstructure is the micro-nano structure of the surface machined by WEDM. Firstly, the mechanical analysis of water droplets placed on the primary array microstructure is carried out by the force balance method. According to Newton's third law, equations containing CA parameters are listed. Secondly, the finite element method (FEM) was used to analogue simulation the distribution of material surface temperature and flow field in the WEDM single pulse discharge machining process. The surface equivalent geometric model of WEDM was established by a uniform arrangement of single pulse pits obtained by simulation, the surface roughness coefficients under different discharge parameters were calculated, and the influence of the surface roughness coefficients on the surface wettability was studied. The numerical results show that the CA is jointly determined by the surface roughness coefficient under different discharge parameters, and the shape and size parameters of the microstructure. Finally, semicircle, rectangular, sawtooth and square column array microstructures were fabricated on EN-GJL-250 surface by high-speed WEDM. Experimental results show: The CA of water droplets on the square column array microstructure is the largest, the predicted values of the CA were in good agreement with the experimental values, and the average relative error was 7.83%.
Preparation of melanin-silver nanocomposites material and its physiological activity in vitro
Authors: Gao Li , Guo Lixiao , Zhang Shuli , Zhao Yinghu , Xie Jun , Liu Linlin , Xu Hongyu 
Published: May 2022

Abstract
In recent years, due to the potential application of metal nanomaterials in the field of medical sectors, the biological preparation of silver nanoparticles is attracting people's interest. Melanin is a natural biological dye, has a variety of biological functions, and has been widely used in the preparation of composites. In this study, melanin-nanometer silver (Mel-AgNPs) composites were prepared by one-step biological method using silver nitrate as raw material and melanin as reducing agent and coating agent. The ultraviolet - visible spectrum of MEL-AgNPS composites showed the maximum absorption wavelength at 403 nm, which proved nano silver formation. The FTIR confirmed the carboxyl group in melanin to reduce the Ag+ reduction as AgNPs, which promoted melanin covered in nano-silver surface. The SEM analysis showed that the morphology of Mel-AgNPs showed a spherical, and the particle diameter was about 30 nm. The element silver in the synthesized Mel-AgNPs was confirmed using EDX to exist silver in the synthetic Mel-AgNPS, and the crystal structure was characterized by XRD. The antibacterial activity experiments showed that Mel-AgNPs composites had inhibitory effect both on Escherichia coli and Staphylococcus aureus, and the inhibitory effects on E.coli is greater than Staphylococcus. In vitro antioxidant experiments showed that Mel-AgNPs composites had strong Fe3+ reduction ability and scavenging activity of DPPH and ABTS radical. The cytotoxicity experiments showed that Mel-AgNPs composite had weak toxicity to normal mouse fibroblast L929 and had inhibitory effect on human breast cancer cell line MCF-7, and Mel-AgNPs composites could down-regulate the level of BCl-2 gene in MCF-7 cells. This indicated that the material could inhibit the growth of cancer cells by regulating the pathways involved in the process of apoptosis and had certain anti-tumor activity. The anti-tumor experiments showed that Mel-AgNPs composites have strong antiviral capabilities to the H3N2 of the influenza virus, which can be used as a promising potential antiviral agent.
Clinical feedback as an additional communication aide in therapy processes: A dual case study of how feedback can influence therapeutic work
Authors: Helleseth Marianne Magnesdotter , McAleavey Andrew , Moltu Christian 
Published: May 2022

Abstract
Background
While routine outcome monitoring and clinical feedback may improve outcomes of psychotherapy, results from efficacy studies have been mixed. Moreover, how clinical feedback is implemented influences how it works for patients and clinicians, and its working mechanisms are not fully understood. Researchers have argued that inviting and using feedback from patients is best conceived of as a clinical skill. In this paper, we use case study methodology to explore and describe feedback’s functions within three clinical skill themes: actualising alliance work, concretising change and stagnation, and verbalising the nonverbal.
Case presentation:
Sonja is a young adult patient with a trauma background. She has a history of serious suicide attempts and distrust in relationships. She attended psychotherapy for eight months. Harald is a middle-aged man with a stable family. Traumatic events in his past has made him conceal own needs and developing depression. He attended psychotherapy for 19 months. Case material include the patient’s clinical feedback over a range of life areas, medical health notes and the therapist’s process notes.
Conclusions
Clinical feedback can be a positive supplement to the therapeutic work and process. The importance of making this as a joint tool between the client and the therapist is significant.
A potential trade-off between wing morphology and colouration for improved flight efficiency in the Larinae
Authors: Goumas Madeleine 
Published: May 2022

Abstract
There are many hypotheses explaining the diversity of colours and patterns found in nature, but they are often difficult to examine empirically. Recent studies show the dark upperside of the wings of gliding birds could reduce drag by decreasing the density of surrounding air. It may therefore be expected that species with darker wings have less efficient wing morphology than their paler counterparts. I conducted a phylogenetic comparative analysis of the Larinae (gulls) to test whether wing loading is a predictor of wing darkness. I found that, for each standard deviation increase in wing loading, wing darkness is predicted to increase by 1.2 shades on the Kodak grey scale. Wing darkness is also negatively correlated with the distance from the equator of species’ breeding and resident ranges. Furthermore, heavier species have lower aspect ratio wings, suggesting that dark wings have evolved to improve the trade-off between maneuverability and long distance flight.
ONCOACH, a prospective study to evaluate the impact of coaching in improving the well- being of oncologists
Authors: Darbas Tiffany , Leobon Sophie , Facchini-Joguet Teeva , Lavau-Denes Sandrine , Randrianasolo Harinaivo Freddy , Troussel Alexandre , Piolle Jean-Marie , PASCAL Valérie , Fourcade Laurent , Deluche Elise 
Published: May 2022

Abstract
Background: The primary endpoint of this pilot program was to determine the feasibility and acceptability of a coaching program in the training of oncologists. Methods: From November 2019 to May 2020, residents or young doctors had a coaching session, once a month for 6 months. Students completed a survey assessing demographic characteristic, stress evaluation, anxiety or/and depression (by the Hospital Anxiety and Depression scale (HAD) and PHQ scale 9) and burnout. Results: Of the 20 eligible students, 90% (18/20) enrolled. Among them 33.4% (6/18) had five sessions with each coach and 55.6% completed all sessions (10/18). The majority of participants (72.2% of learners; 13/18) perceived the program was highly valuable, with 50% (9/18) of learners who would like to do coaching again. They found that coaching beneficial and they recognized that it was beneficial for feeling more comfortable at work (66.6%), to get the important messages across (50%) and to reduce stress at work (55.5 %). The stress evaluated by the short 9-item Psychological Stress Measurement questionnaire decreased during the coaching training (p = 0.0446) and remained stable after coaching training at M12 (p = 0.4). Anxiety, depression and burn-out was remained stable during and after the coaching. Conclusion: This pilot study demonstrated preliminary feasibility and acceptability for coaching and had positive impact on stress reduction.
Surrogate modelling for the forecast of Seveso-type atmospheric pollutant dispersion
Authors: Kocijan Jus , Hvala Nadja , Perne Matija , Mlakar Primoz , Grasic Bostjan , Boznar Marija Zlata 
Published: May 2022

Abstract
This paper presents a framework for the development of a computationally-efficient surrogate model for air pollution dispersion.
Numerical simulation of air pollution dispersion is of fundamental importance for the mitigation of pollution in Seveso-type accidents, and, in extreme cases, for the design of evacuation scenarios for which long-range forecasting is necessary. Due to the high computational load, sophisticated simulation programs are not always useful for prompt computational studies and experimentation in real time. Surrogate models are data-driven models that mimic the behaviour of more accurate and more complex models in limited conditions. These models are computationally fast and enable efficient computer experimentation with them. We propose two methods. The first method develops a grid of independent dynamic models (GIM) of the air pollution dispersion. The second method develops a reduced grid with interpolation of outputs (RGI). Both are demonstrated on an example of a realistic, controlled experiment with limited complexity based on an approximately 7 km radius around the thermal power plant in Šoštanj, Slovenia. The results show acceptable matching of behaviour between the surrogate and original model and noticeable improvement in the computational load. This makes the obtained surrogate models appropriate for further experimentation and confirms the feasibility of the proposed method.
An Algorithm of Deformation Image Correction Based on Spatial Mapping
Authors: Deng Xiangyu , Zhang Aijia , Ye Jinhong 
Published: May 2022

Abstract
The original image has geometric deformation in geometric position, shape, size and orientation due to the shooting angle or capturing in the process of image shooting. It brings a lot of inconveniences and great challenges in image processing field such as image fusion, de-noising, recognition and segmentation. In order to improve the processing ability and recognition accuracy of deformation images, an adaptive image deformity correction algorithm for the quadrilateral and the triangular is proposed. Firstly, the deformation image is pre-processed and the contour of image edge is extracted. And then, discrete points of image edge are found to locate image edge accurately. Finally, the deformation of the quadrilateral or the triangle is processed into standard rectangle or equilateral triangle image by using the proposed algorithm of three-dimensional homography transformation, so as to complete the transformation from irregular image to regular image adaptively. A lot of experiments show that the proposed algorithm is superior to the traditional methods such as Hough transform and Radon transform, which improves the effect of deformation images correction, solves the problem of geometric deformation images well, and provides a new technical method for image processing of deformation images.
Socio Economic Condition of Tuk-Tuk Drivers With Their Problems Related to Tuk-Tuk Driving: A Case Study of Berhampore Municipality in Murshidabad District, West Bengal
Authors: Das Mousumi 
Published: May 2022

Abstract
Nowadays, E-Rickshaw is new the most popular short-distance mode of transport in the urban transport system, locally called Tuk-Tuk. This has made it possible to transport people and goods from one place in the city to other. It is an eco-friendly transportation system. Many people from different wards of Berhampore Municipality have found a new way to earn a living through it. But, unplanned urbanization, lack of road space, and such rapid growth of Tuk-Tuk became a burden on the existing transport realm. This is creating traffic congestion in the city. At present women are making a living from it. Although Tuk-Tuk has significantly reduced the number of the van, rickshaw pullers.There are about four to five thousand Tuk-Tuks in the area but the number of registered Tuk-Tuk is 1109, under Berhampore Municipality. It also focuses on urban environmental problems and the prospect of the Tuk-Tuk in the urban area.
Neonatal enterostomy complications：Can a simple drainage device inspired by prepuce surgery prevent？
Authors: Wang Kun , Cai Jing , Lu Ying Chou , Yu Jia Kang , Li Xiao Wei , Zhai Guo Min , Wu Gang Quan 
Published: May 2022

Abstract
Background Complications frequently occur after neonatal enterostomy. Enterostomy formation is a common outcome following emergency neonatal laparotomy. This study aims aimed to determine whether the incidence of complications after enterostomy can be decreased with a drainage device and we introduce a new method for improving proximal enterostomy in newborns.Methods This study is a retrospective case note review of emergency neonatal enterostomy incidence over 3 years (2/2016-2/2019） at our center. All surgeries were performed by a single surgeon. Intraoperative findings and complications, operative times, and postoperative complications were reviewed for all children.Results All 47 surgeries were successfully completed (32 boys and 15 girls). Average daily age (3.49±5.61) d (mean±S.D.). Full-term children in 22 cases, 25 infants were preterm. Eleven patients were diagnosed with ARMs, twenty with NEC, and eleven with SIP requiring laparotomy. Two patients had congenital intestinal atresia(CIA),one had incarcerated inguinal hernia(IIH), and Two had congenital megacolon(HD). Twenty of these cases used a modified drainage device, One case of prolapse of the intestinal, one case of premature surgery due to excessive orifice flow, and one case of periostomy dermatitis，Ohter patients not experienced intraoperative or postoperative complications.Conclusions Based on our preliminary observations, the simple drainage device is a safe and effective operation device that can reduce the risk of stoma-related complications.