bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthcare professionals' perspectives on the use of medicinal cannabis to manage chronic pain: A systematic search and narrative review
Authors: Cheng Katherine Y. C. , Harnett Joanna E. , Davis Sharon R. , Eassey Daniela , Law Susan , Smith Lorraine 
Published: September 2022

AbstractRationale, aims, and objectivesChronic pain is a global public health problem that negatively impacts individuals' quality of life and imposes a substantial economic burden on societies. The use of medicinal cannabis (MC) is often considered by patients to help manage chronic pain as an alternative or supplement to more conventional treatments, given enabling legalization in a number of countries. However, healthcare professionals involved in providing guidance for patients related to MC are often doing so in the absence of strong evidence and clinical guidelines. Therefore, it is crucial to understand their perspectives regarding the clinical use and relevance of MC for chronic pain. As little is known about attitudes of HCPs with regard to MC use for chronic pain specifically, the aim of this review was to identify and synthesize the published evidence on this topic.MethodsA systematic search was conducted across six databases: MEDLINE, EMBASE, CINAHL, Scopus, Web of Science, and PubMed from 2001 to March 26, 2021. Three authors independently performed the study selection and data extraction. Thematic analysis was undertaken to identify key themes.ResultsA total of 26 studies were included, involving the United States, Israel, Canada, Australia, Ireland, and Norway, and the perspectives of physicians, nurses, and pharmacists. Seven key themes were identified: MC as a treatment option for chronic pain, and perceived indicated uses; willingness to prescribe MC; legal issues; low perceived knowledge and the need for education; comparative safety of MC versus opioids; addiction and abuse; and perceived adverse effects;ConclusionTo support best practice in the use of MC for chronic pain, healthcare professionals require education and training, as well as clinical guidelines that provide evidence‐based information about efficacy, safety, and appropriate dosage of products for this indication. Until these gaps are addressed, healthcare professionals will be limited in their capacity to make treatment recommendations about MC for people/patients with chronic pain.
Pyruvate transporter BnaBASS2 impacts seed oil accumulation in Brassica napus
Authors: Tang Shan , Guo Ning , Tang Qingqing , Peng Fei , Liu Yunhao , Xia Hui , Lu Shaoping , Guo Liang 
Published: September 2022

SummaryBile acid: sodium symporter family protein 2 (BASS2) is a sodium‐dependent pyruvate transporter, which transports pyruvate from cytosol into plastid in plants. In this study, we investigated the function of chloroplast envelope membrane‐localized BnaBASS2 in seed metabolism and seed oil accumulation of Brassica napus (B. napus). Four BASS2 genes were identified in the genome of B. napus. BnaA05.BASS2 was overexpressed while BnaA05.BASS2 and BnaC04.BASS2‐1 were mutated by CRISPR in B. napus. Metabolite analysis revealed that the manipulation of BnaBASS2 caused significant changes in glycolysis‐, fatty acid synthesis–, and energy‐related metabolites in the chloroplasts of 31 day‐after‐flowering (DAF) seeds. The analysis of fatty acids and lipids in developing seeds showed that BnaBASS2 could affect lipid metabolism and oil accumulation in developing seeds. Moreover, the overexpression (OE) of BnaA05.BASS2 could promote the expression level of multiple genes involved in the synthesis of oil and the formation of oil body during seed development. Disruption of BnaA05.BASS2 and BnaC04.BASS2‐1 resulted in decreasing the seed oil content (SOC) by 2.8%–5.0%, while OE of BnaA05.BASS2 significantly promoted the SOC by 1.4%–3.4%. Together, our results suggest that BnaBASS2 is a potential target gene for breeding B. napus with high SOC.
Moderating role of coping in the association between minority stress and suicidal ideation and suicide attempts among sexual and gender minority young adults
Authors: de Lange Jennifer , Baams Laura , Bos Henny , Bosker Roel , Dumon Eva , Portzky Gwendolyn , Robinson Jo , van Bergen Diana 
Published: September 2022

AbstractObjectiveThis study examined associations of minority stressors (i.e., victimization, internalized homonegativity, and stigma consciousness), and coping styles (i.e., active, avoidant, and passive) with suicidal ideation and suicide attempts (suicidality) among sexual and gender minority (SGM) young adults, and whether coping style moderated these associations.MethodsLogistic regression analyses examined these associations among 1432 SGM young adults (ages 18–29).ResultsMinority stressors and passive coping were associated with a higher likelihood of suicidality. Avoidant coping was associated with a lower likelihood of lifetime suicidal ideation and attempts among sexual minority participants, and active coping with a lower likelihood of past‐year suicidal ideation among sexual minority participants. Moderation analyses among sexual minority participants showed that when avoidant coping was high, associations between low victimization (compared with no victimization) and lifetime suicide attempts, and stigma consciousness and lifetime suicide attempts became non‐significant, and the association between internalized homonegativity and lifetime suicide attempts became significant. Among gender minority participants, when passive coping was high the association between low victimization and lifetime suicidal ideation became significant.ConclusionThis study underlines the importance of minority stress and coping for suicidality among SGM young adults and the need for more research regarding the role of coping.
The use of lateral arthroscopy portals for the management of bilateral osteochondritis dissecans of the radial head in an English bulldog
Authors: Shetler Samantha E. , Verpaalen Valentine D. , Hinson Whitney D. , De Lombaert Mélissa , Belhorn Stephanie A. , Giglio Robson F. 
Published: September 2022

AbstractObjectiveTo report a case of bilateral radial head osteochondritis dissecans (OCD) in a dog treated via lateral elbow arthroscopy portals.Study designCase report.AnimalsSix month old female spayed English bulldog.MethodsThe dog was presented for a left thoracic limb lameness localized to the elbow. Computed tomography revealed bilaterally symmetrical mineralized fragments in the lateral compartment of the elbow joint and blunting of the medial coronoid processes. The fragments were associated with a thin donation bed along the caudolateral articular surface of the radial head with moderate surrounding subchondral bone sclerosis. Bilateral elbow arthroscopy was pursued. Arthroscopy was initiated via a standard medial approach, which allowed for abrasion arthroplasty of the radial incisure and medial coronoid process but provided insufficient access to the radial head lesions. A lateral arthroscopic approach was subsequently performed and provided excellent access to the radial head for fragment retrieval and abrasion arthroplasty.ResultsHistopathology of the radial head fragments revealed mild cartilage degeneration and retention of cartilaginous cores within subchondral bone, consistent with OCD. Complete resolution of lameness and elbow pain were observed on clinical examination 5 months postoperatively.ConclusionRadial head OCD can occur as a rare component of elbow dysplasia in growing dogs, and fragment retrieval with abrasion arthroplasty via lateral arthroscopic portals may be an effective treatment option.
Design and topographic evaluation of a canine humeral anatomic plating system (CHAPS) for humeral condylar fracture repair in spaniels
Authors: Burton Neil J. , Horsewill Hannah , Sparks Tim H. , Caruso Ilaria 
Published: September 2022

AbstractObjectiveTo design a precontoured plating system for humeral condylar fracture repair in spaniels with humeral intracondylar fissure (HIF) and quantify accuracy of fit of the system on 3D printed bone models.Study designExperimental on 3D printed models.MethodsThe plating system was based on morphometric data obtained from CT. Plates were applied to models and impression material was measured under the plates at points of interest to define plate bone gap (PBG). Data on locking screw interference on plate application were also obtained.ResultsEleven elbows models were plated. Statistical analysis to assess for any difference in PBG measurements between left and right humuri revealed two loci (3 and 17) under the lateral plate and two loci (3 and 17) under the medial plate. On cumulate portion analysis, 67% of lateral plate loci and 80% of medial plate loci had a PBG of ≤2 mm respectively. An incidence of 2.1% (3/143) screw interference occurred.ConclusionDesign of a contoured plating system for application to humeral models from spaniels with HIF and its application with objective measurement of PBG is described. The majority of the loci measured under both lateral and medial plates had a BPG of ≤2 mm and the incidence of locking screw interference on plate application was low.Clinical significanceThis novel system may have application for the stabilization of humeral condylar fractures in spaniels avoiding the need for plate contouring and minimizing the incidence of locking screw interference.
A morphometric and genetic investigation of Opuntia engelmannii population variation in Africa
Authors: Mbonani Siphosenkosi , Glennon Kelsey L. , Byrne Marcus J. 
Published: September 2022

AbstractOpuntia engelmannii Salm‐Dyck (Cactaceae:Opuntioideae) is a morphologically variable cactus that has invaded pasture lands in South Africa and Kenya. Biological control of invasive Opuntia species can be very successful when the correct agent is matched with the appropriate host. This research investigated the similarity (morphological and genetic) between several populations of O. engelmannii and a morphologically uniform, O. stricta, that occur in South Africa and Kenya to help understand the identity of the target weed. Spine and cladode morphology showed that the Limpopo (South African) and Kenyan populations were most similar, while the spiny Eastern Cape (South African) population was more similar to Opuntia stricta. Multivariate analysis showed that spine morphometry was a useful diagnostic character in identifying different putative O. engelmannii populations in the field. In addition, we used amplified fragments length polymorphisms to estimate genetic similarity and genetic structure among populations that represent the morphologically variable populations. There was relatively little differentiation in the population structure between the Limpopo and Kenyan populations. The spiny Eastern Cape population showed moderate genetic differentiation (FST = 0.05 − 0.15) relative to other O. engelmannii populations and was genetically more similar to the O. stricta population. These results will facilitate the search for suitable biocontrol agents by directing future collections of the appropriate biotype of Dactylopius opuntiae Cockerell (Hemiptera: Dactylopiidae) to relevant populations of O. engelmannii in its home range. In addition, given the genetic similarity of the spiny Eastern Cape population to O. stricta, we recommend the efficacy of D. opuntiae ‘stricta’ biotype be tested on the spiny Eastern Cape population as a potential biocontrol agent.
A Quantitative Study of Transport of Surfactant Boli in a Three-Dimensional Lung Model of Neonates
Authors: Combs Hannah , Shark Taylor , Heiss Jacob , Raessi Mehdi , Tavana Hossein 
Published: September 2022

Abstract
Neonatal respiratory distress syndrome is mainly treated with the intratracheal delivery of pulmonary surfactants. The success of the therapy depends on the uniformity of distribution and efficiency of delivery of the instilled surfactant solution to the respiratory zone of the lungs. Direct imaging of the surfactant distribution and quantifying the efficiency of delivery is not feasible in neonates. To address this major limitation, we designed an eight-generation computational model of neonate lung airway tree using morphometric and geometric data of human lungs and fabricated it using additive manufacturing. Using this model, we performed systematic studies of delivery of a clinical surfactant either at a single aliquot or at two aliquots under different orientations of the airway tree in the gravitational space to mimic rolling a neonate on its side during the procedure. Our study offers both a novel lung airway model and new insights into effects of the orientation of the lung airways and presence of a pre-existing surfactant film on how the instilled surfactant solution distributes in airways.
Maximum Likelihood Identification of Cavitation Instabilities in Axial Inducers
Authors: Tumminia Matteo , Valentini Dario , Pace Giovanni , Hadavandi Ruzbeh , Torre Lucio , Pasini Angelo , d'Agostino Luca 
Published: September 2022

Abstract
The article illustrates the results of an exploratory study on the effectiveness of maximum likelihood Bayesian estimation in the identification of cavitation instabilities in axial inducers using the blade-to-blade pressure measured by a single transducer flush-mounted on the impeller casing. The typical azimuthal distribution of the pressure in the blade channels is parameterized and modulated in space and time for theoretically reproducing the expected pressure generated by known forms of cavitation instabilities (cavitation surge auto-oscillations, n-lobed synchronous/asynchronous rotating cavitation, and higher-order surge/rotating cavitation modes). The power spectra of the theoretical pressure so obtained in the rotating frame are transformed in the stationary frame, corrected for frequency broadening effects, and parametrically fitted by maximum likelihood estimation to the measurements of the pressure on the inducer casing just downstream of the blade leading edges. In addition to its fundamental frequency, each form of instability generates a characteristic spectral distribution of sidebands. The identification uses this information for successfully discriminating flow oscillation modes occurring simultaneously with intensities differing by up to one order of magnitude. The method returns the estimates of the model parameters and their standard errors, allowing one to assess the accuracy and statistical significance of the identification. The results first demonstrate that elementary maximum likelihood Bayesian identification is indeed capable to effectively detect and characterize the occurrence of flow instabilities in cavitating inducers at a fraction of the experimental and postprocessing costs and complexities of traditional cross-correlation methods.
A New Approach to Estimate Particulate Matter Emissions From Ground Certification Data: The nvPM Mission Emissions Estimation Methodology
Authors: Ahrens Denise , Méry Yoann , Guénard Adrien , Miake-Lye Richard C. 
Published: September 2022

Abstract
Estimating nonvolatile particulate matter (nvPM)—or black carbon—emissions during an aircraft mission is extremely challenging because of the lack of reliable data in flight. For this reason, a detailed study has been undertaken to estimate in-flight emissions from data measured on the ground during engine certification. Aircraft engine emissions certification is based on the “Landing and Take-Off” (LTO) cycle developed by the Committee on Aviation Environmental Protection (CAEP) of the International Civil Aviation Organization (ICAO). It represents operations below 3000 ft. The aim of this regulation is to control and reduce pollutant emissions in the vicinity of the airport. Carbon monoxide (CO), unburnt hydrocarbon (UHC), and nitrogen oxides (NOx) have been regulated using the LTO cycle by different international standards for four decades. New certification standards on nvPM have been introduced recently. The first one, put in place in CAEP10, regulates the peak nvPM mass concentration. It has been in effect since 2020. The second set established in CAEP11 regulates the nvPM mass and number of emissions on the LTO cycle and it becomes effective in 2023. With these regulations, manufacturers are now reporting nvPM emissions data publicly. All emissions data of in-production engines, and some legacy engines, are available in the engine emissions data bank (EEDB), downloadable from the European Union Aviation Safety Agency (EASA) website. Methodologies have been proposed to estimate emissions at altitude and calculate total mission emissions for NOx, i.e., the “Boeing Fuel Flow Method” or the “DLR Döpelheuer and Lecht” methodology, which are only relying on these publicly available data from the EEDB. In the following, a new methodology for estimating nvPM emissions at altitude is proposed. The methodology was developed and validated in the framework of the CAEP technical working groups. It comprises four dedicated steps. In the present article, the different steps are explained and validation data is provided as applicable. Examples of in-production engines are analyzed, discussed, and compared against the full methodology using proprietary engine performance and emissions certification data. Following the proposed methodology, total nvPM mass and number of mission emissions can be estimated and used for emissions inventories and evaluation of climate impacts.
Power Flow Optimization for a Hybrid-Electric Propulsion System
Authors: Papadopoulos Konstantinos I. , Nasoulis Christos P. , Ntouvelos Elissaios G. , Gkoutzamanis Vasilis G. , Kalfas Anestis I. 
Published: September 2022

Abstract
This study deals with the optimization of performance for a hybrid-electric propulsion system. It focuses on the modeling and power management frameworks, while evaluation is done on a single flight basis. The main objective is to extract the maximum out of the novel powertrain archetype. Two hybridization factors are considered. The pair helps to describe the degree of hybridization at the power supply and power consumption levels. Their revised mathematical definition facilitates a unique method of hybrid-electric propulsion system modeling that maximizes the conveyed amount of information. An in-house computational tool is developed. It employs a genetic algorithm optimizer in the interest of managing power usage during flight. Energy consumption is set as the objective function. The operation of a 19-seater, commuter aircraft is investigated. Turbo-electric, series-hybrid, parallel-hybrid, and series-parallel variants are derived from a generic composition. An analysis on their optimized performance, with different technological readiness levels for 2020 and 2035, is aimed at identifying where each system performs best. Considering 2020 technology, it does not yield a viable hybrid-electric configuration, without suffering significant payload penalties. Architectures relying on mechanical propulsors show promise of 15% reduction to energy consumption, accounting for 2035 readiness levels. The concepts of Boundary Layer Ingestion and Distributed Propulsion display the potential to boost electrified propulsion. The series-hybrid and series-parallel configurations are the primary beneficiaries of these concepts, displaying up to 30% reduction in fuel and 20% reduction in energy consumption.
Compressor Surge Precursors for a Turbocharger Coupled to a Pressure Vessel
Authors: Silvestri Paolo , Reggio Federico , Niccolini Marmont Du Haut Champ Carlo Alberto , Ferrari Mario L. , Massardo Aristide Fausto 
Published: September 2022

Abstract
Dynamic compressors operating region is mainly constrained by fluid-dynamic instabilities occurring at low mass flow rate conditions, such as surge and rotating stall. This work presents a vibro-acoustic experimental investigation on a centrifugal compressor of an automotive turbocharger aimed to identify and confirm some surge precursor values in correspondence of its inception conditions. The experimental campaign was carried out on a turbocharger equipped by a vaneless diffuser compressor exploited for the pressurization of an innovative solid oxide fuel cell (SOFC) emulator. The investigated turbocharger is coupled with a pressure vessel for a former emulation activity on a pressurized SOFC. In such kind of plants, the joint effect of large volume size downstream the compressor makes more complex the dynamic behavior of the whole system during transients, thus significantly increasing surge onset risk.
The main goal is to define a suitable quantitative indicator to detect in advance surge inception by relying only on system vibro-acoustic response. Several transient from a compressor stable condition to surge instability onset were performed by progressively closing specific valves in the air line. When moving close to surge , vibro-acoustic signals were acquired at a high sampling rate to investigate blade passage phenomena which might interact with rotating stall inception. Meanwhile, pressures, temperatures and mass flow rates measured at a lower sampling rate to correlate compressor vibro-acoustic and performance behavior. Cyclostationary analysis was performed on vibro-acoustic acquired signals to provide innovative diagnostic and predictive solutions (precursors) for early surge detection.
Theoretical and Experimental Comparisons for Rotordynamic Coefficients of a Multiscratched Tilting Pad Journal Bearing
Authors: Hassini Mohamed-Amine , Zhang Silun , Chatterton Steven , Pennacchi Paolo 
Published: September 2022

Abstract
This paper presents a thermo-elasto-hydrodynamics model (TEHD) based on a mass conservative generalized Reynolds equation, coupled with three-dimensional (3D) energy equation for the oil film, and a full 3D thermo-mechanical model for the pads. The model uses a regularization technique to consider film thickness discontinuities created by scratches. The numerical results are compared to the experimental results obtained from a rocker-backed, five tilting pads journal bearing (TPJB) with single and multiple scratches. The numerical model achieved good agreement, especially with respect to pad temperatures and dynamic coefficients. Discrepancies were observed at low speed but only on the stiffness in the load direction. The numerical model shows a significant drop in the pressure field at the location of the scratches, and a significant pressure rise between two consecutive scratches accompanied by a decrease in film thickness.
Performance Assessment of Tesla Expander Using 3D Numerical Simulation
Authors: Renuke Avinash , Traverso Alberto 
Published: September 2022

Abstract
Bladeless or Tesla turbines consist of several flat parallel disks mounted on a shaft with a narrow gap between them. The analytical solution of Navier-Stokes equations for the flow between disks has been extensively studied in the past. However, there is a significant impact of the stator exit-flow conditions on the performance and flow behavior inside the rotor of the Tesla turbine. There has been limited research on flow characterization and performance evaluation of stator-rotor interaction of the Tesla expander using 3D numerical simulation. The challenge arises due to a very high aspect ratio of the Tesla rotor (diameter to gap ratio &gt; 1000). 3D numerical modeling with a hexahedral mesh of the nozzle/stator with the commercial software is presented. The simulation is performed for a wide range of inlet pressures and rotational speeds. This work focuses on the stator performance, the stator-rotor interaction, the rotor entry losses due to disk tip, the rotor tip velocity ratio and the degree of reaction on the performance of the Tesla expander.The peak efficiency of 58% is predicted for 3 bar inlet pressure and a rotational speed of 30000 rpm for a 3 kW machine with air as a working fluid. The 3D numerical analysis provides insights on flow characterization, mainly stator-rotor interaction and flow between disks at different mass flows. Numerical results are also compared with experimented test results performed on a 100-W and a 3-kW air expander.