bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH MODEL PEMBELAJARAN READING QUESTIONING AND ANSWERING (RQA) BERBANTUAN APLIKASI KIPIN SCHOOL TERHADAP HASIL BELAJAR KOGNITIF SISWA KELAS VII SMP NEGERI 3 KOTA TERNATE
Authors: Ummiyati Ummiyati , Hasan Said , Bahtiar Bahtiar 
Published: June 2022

The teaching and learning process is an interaction between teachers and students through reciprocal communication that takes place in an effective situation to achieve learning objectives. Entering a decade of the 21st century, the development of information and communication technology in the era of the industrial revolution 4.0 has had a significant influence on learning that must adapt and use technology in the current era, many application-based learning technologies in the field of education can be utilized by teachers as media. or tools in learning to support the teaching and learning process. The aims of this research are to determine the effect of the Reading questioning and answering learning model assisted by the Kipin School application on cognitive learning outcomes. This research is a quasi-experimental research. The sample of this study consisted of two classes, namely class VIIc as the experimental class and class VIIa as the control class with a total of 57 students. The instruments used tests to measure cognitive learning outcomes. Data analysis used the SPSS-assisted normality and homogeneity test, while the hypothesis test used anacova test and regression test. The results showed that there was an effect of the Reading questioning and answering learning model assisted by the Kipin School application on learning outcomes. cognitive, namely with a significant value level of 0.001> 0.05 .
THE RIGHT OF EXAMINATION OF WITNESSES WITH THE DECISIONS OF EUROPEAN COURT ON HUMAN RIGHTS AND TURKISH CONSTITUTIONAL COURT
Authors: DEMİR Hatice Kübra 
Published: June 2022

The right to question witnesses is regulated in subparagraph d of paragraph 3 of article 6 of the European Convention on Human Rights. According to this regulation, the accused has the right to interrogate or have the witnesses of the claim and defense interrogated. As a rule, the interrogation of allegation and defense witnesses is done in front of the court. However, in some exceptional cases, witnesses cannot or do not appear before the court. In such cases, the right of the accused to a fair trial may be violated.
The European Court of Human Rights and, accordingly, the Constitutional Court have set certain criteria as to whether the defendant's right to a fair trial is violated if the witnesses are not questioned in front of the court. In this study, the right to question witnesses is tried to be explained in the context of the decisions given by the European Court of Human Rights and the Constitutional Court and in line with the criteria determined.
Towards the Development of a Device for Assessing the Pliability of Burn Scars
Authors: Dalle Mura Francesco , Governi Lapo , Furferi Rocco , Cervo Marta , Puggelli Luca 
Published: June 2022

Burn injuries requires post-accident medical treatment. However, the treatment of burns does not end with first aid because scarred skin must be managed for many years, and in some circumstances, for life. The methods used to evaluate the state of a burn scar based, for instance, on Patient and Observer Scar Assessment Scale or similar ones, often lacks in univocally assessing the scarred skin’s state of health. As a result, the primary aim of this research is to design and build a prototype that can support the doctor during scar assessment, and eventually therapy, by providing objective information on the state of the lesion, particularly the value of skin pliability. The developed tool is based on the depressomassage treatment probe named LPG, currently used to treat burn scars in a number of hospitals. It consists of a non-invasive massage technique using a mechanical device to suction and mobilize scar tissue and is used as a post-operative treatment to speed up the healing process to make the mark of the scar less visible. The prototype is specifically designed to be manufactured using Additive Manufacturing and was validated comparing its performances against the ones of a certified instrument (i.e., the Romer Absolute ARM with RS1 probe). Validation was carried out by designing and developing a tool to put the RS1 probe in the same measurement conditions of the new prototype probe. Tests performed to assess the performance of the devised prototype show that the probe developed in this work is able to provide measurements with a sufficient degree of accuracy (maximum error ±0.1 mm) to be adopted for a reliable estimation of the pliability value in a hospital environment.
Prediction and Sensitivity Analysis of CO2 Capture by Amine Solvent Scrubbing Technique Based on BP Neural Network
Authors: Fu Jiangtao , Chang Yufeng , Huang Bijie 
Published: June 2022

With the rapid development of artificial intelligence, bionic algorithm has been gradually applied in various fields, and neural network has become an important and hot issue in the field of scientific research and engineering in recent years. This article proposes a BP neural network model to predict the capture ability and sensitivity of CO2 in monoethanolamine (MEA) aqueous scrubbing technique from a 2 × 1,000 MW coal-fired power plant expansion project in eastern China. The predicted values agree well with the experimental data with a satisfactory mean square root error (MSRE) ranging from 0.001945 to 0.002372, when the change in the circulation amount of MEA and the accuracy of prediction results of the back propagation neural network (BPNN) algorithm is as high as 96.6%. The sensitivity analysis results suggested that the flue gas amount has a marginal effect on the system performance, while further attention should be paid to the MEA circulation amount, which is crucial to the CO2 capture amount. The temperature profiles show the typical behavior of the reactive absorption column where a temperature bulge can be seen at the bottom of the column due to the high L/G ratio of the experimental and prediction results. The coefficients of correlation R2 with the change of MEA circulation amount, change of CO2 concentration, and steam consumption are 0.97722, 0.99801, and 0.98258, respectively. These results have demonstrated that the present study has established the BPNN algorithm as a consistent, reliable, and robust system identification tool for CO2 capture by the amine solvent scrubbing technique of operation in coal-fired power plants.
AuNPs@MIL-101 (Cr) as a SERS-Active Substrate for Sensitive Detection of VOCs
Authors: Xie Dan , Wang Ruimeng , Fu Jinghao , Zhao Zhongxing , Li Min 
Published: June 2022

Surface-enhanced Raman scattering (SERS) is an important and powerful analytical technique in chemical and biochemical analyses. Metal–organic frameworks (MOFs) can effectively capture volatile organic compounds (VOCs) with high adsorption capacity and fast kinetics, and the local surface plasmon resonance characteristics of gold nanoparticles can quickly and effectively distinguish different VOCs by SERS. Combining both, we designed a novel SERS substrate based on embedding gold nanoparticles (AuNPs) within MIL-101(Cr) for the recognition of various VOCs in the gaseous phase. Occupying of AuNPs inside MIL-101(Cr) increased the micropore-specific surface area of AuNPs@MIL-101(Cr), which enabled AuNPs@MIL-101(Cr) to absorb more toluene molecules and consequently realized its high detection sensitivity. The detection limits for toluene, 4-ethylbenzaldehyde, and formaldehyde were down to 6, 5, and 75, ppm respectively. Moreover, this substrate could be used for detecting different VOCs simultaneously. Finally, we discussed the enhancement of AuNPs outside and inside MIL-101(Cr) on the Raman signal.
Self-Assembling Imageable Silk Hydrogels for the Focal Treatment of Osteosarcoma
Authors: Peng Zhibin , Li Ming , Wang Yuan , Yang Hongbo , Wei Wei , Liang Min , Shi Jianhui , Liu Ruixuan , Li Rui , Zhang Yubo , Liu Jingsong , Shi Xu , Wan Ran , Fu Yao , Xie Rui , Wang Yansong 
Published: June 2022

Background: The standard treatment for osteosarcoma comprises complete surgical resection and neoadjuvant chemotherapy, which may cause serious side effects and partial or total limb loss. Therefore, to avoid the disadvantages of traditional treatment, we developed self-assembling imageable silk hydrogels for osteosarcoma.Methods: We analysed whether iodine induced apoptosis in MG-63 and Saos-2 cells by using CCK-8 and flow cytometry assays and transmission electron microscopy. Western blotting was used to analyse the pathway of iodine-induced apoptosis in osteosarcoma cells. PEG400, silk fibroin solution, polyvinylpyrrolidone iodine (PVP-I), and meglumine diatrizoate (MD) were mixed to produce an imageable hydrogel. A nude mouse model of osteosarcoma was established, and the hydrogel was injected locally into the interior of the osteosarcoma with X-ray guidance. The therapeutic effect and biosafety of the hydrogel were evaluated.Results: Iodine treatment at 18 and 20 µM for 12 h resulted in cell survival rate reduced to 50 ± 2.1% and 50.5 ± 2.7% for MG-63 and Sao-2 cells, respectively (p &lt; 0.01). The proportion of apoptotic cells was significantly higher in the iodine-treatment group than in the control group (p &lt; 0.05), and apoptotic bodies were observed by transmission electron microscopy. Iodine could regulate the death receptor pathway and induce MG-63 and Saos-2 cell apoptosis. The hydrogels were simple to assemble, and gels could be formed within 38 min. A force of less than 50 N was required to inject the gels with a syringe. The hydrogels were readily loaded and led to sustained iodine release over 1 week. The osteosarcoma volume in the PEG-iodine-silk/MD hydrogel group was significantly smaller than that in the other three groups (p &lt; 0.001). Caspase-3 and poly (ADP-ribose) polymerase (PARP) expression levels were significantly higher in the PEG-iodine-silk/MD hydrogel group than in the other three groups (p &lt; 0.001). Haematoxylin and eosin (H&amp;E) staining showed no abnormalities in the heart, liver, spleen, lung, kidney, pancreas or thyroid in any group.Conclusions: Self-assembling imageable silk hydrogels could be injected locally into osteosarcoma tissues with X-ray assistance. With the advantages of good biosafety, low systemic toxicity and minimal invasiveness, self-assembling imageable silk hydrogels provide a promising approach for improving the locoregional control of osteosarcoma.
Predictors of Occurrence and 30-Day Mortality for Co-Infection of Carbapenem-Resistant Klebsiella pneumoniae and Carbapenem-Resistant Acinetobacter baumannii
Authors: Lv Dongmei , Zuo Yan , Wang Yuerong , Wang Zhongxin , Xu Yuanhong 
Published: June 2022

BackgroundThe phenomenon of co-infection with multiple carbapenem-resistant bacteria is growing, which pose a great challenge for infection control and treatment. This study aimed to analyze predictors of occurrence and 30-day mortality for carbapenem-resistant Klebsiella pneumoniae and carbapenem-resistant Acinetobacter baumannii co-infection.MethodsFrom June 2018 to June 2021, clinical data of 103 patients co-infected with carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-resistant Klebsiella pneumoniae (CRKP) were collected from a tertiary teaching hospital in Anhui Province, China. The clinical characteristics and predictors of mortality were analyzed. Meanwhile, the bacterial isolates were characterized for drug susceptibility, multi-locus sequence typing, and drug resistance genes.ResultsThe multivariate analysis revealed that fiberoptic bronchoscopy (p = 0.005, OR=2.72), repeat transfusions (p = 0.008, OR= 2.23) and exposure to tigecycline (p = 0.002, OR = 6.58) were independent risk factors for CRKP and CRAB co-infection. Neutrophil ≥11.9*109 (p = 0.035, adjusted HR = 3.12) and C-reactive protein ≥ 149 mg/L (p = 0.009, adjusted HR = 4.41) were found associated with 30-day mortality. Combined neutrophil with C-reactive protein could predict 30-day mortality, of which AUC value was 0.791 (95%CI: 0.661-0.921). KPC (46/51, 90.2%) was the most common carbapenemase in CRKP. 33 isolates of CRKP belong to ST11 (33/51, 64.7%), and three new ST types ST5882, ST5883, ST5885 were detected.ConclusionsInvasive operations and antibiotics exposure can lead to CRKP and CRAB co-infection. Combined neutrophil with C-reactive protein could predict 30-day mortality.
Markers of Atrial Cardiopathy in Severe Embolic Strokes of Undetermined Source
Authors: Acampa Maurizio , Cartocci Alessandra , Domenichelli Carlo , Tassi Rossana , Guideri Francesca , Lazzerini Pietro Enea , Martini Giuseppe 
Published: June 2022

Background and PurposeThe current definition of embolic strokes of undetermined source (ESUS) seems to be too broad, including strokes due to heterogeneous mechanisms, such as atrial cardiopathy and other occult cardiac conditions, aortic arch plaques, and non-stenosing atherosclerosis, that can be differently associated with clinical stroke severity at the time of presentation. The aim of our study was to assess the possible association between neurological deficit severity and presence of markers of atrial cardiopathy in ESUS.MethodsWe retrospectively reviewed the medical records of a cohort of 226 ESUS patients (105 M, 121 F), that were divided into two groups according to the severity of neurological deficit (99 mild strokes with NIHSS ≤ 5 and 127 severe strokes with NIHSS &gt;5). The following indices of atrial cardiopathy were evaluated: P wave dispersion, P wave max, P wave min, P wave mean, P wave index, P wave axis, left atrial size.ResultsPatients with severe ESUS were significantly older (74 ± 12 vs. 67 ± 14 years, P &lt; 0.001) and female sex was prevalent (67 vs. 36%, P &gt; 0.001); they had higher values of P-wave-dispersion (51 ± 14 vs. 46 ± 13, P = 0.01), P-wave-max (131 ± 20 vs. 125 ± 15 ms, P = 0.01), P-wave-index (16 ± 5 vs. 15 ± 5 ms, P = 0.01), left atrial size (20 ± 6 vs. 18 ± 4 cm2, P = 0.01), left atrial volume index (31 ± 14 vs. 27 ± 11 ml/m2, P = 0.04), in comparison with mild ESUS. An abnormal P wave axis was detected more frequently in severe ESUS (21 vs. 9%, P = 0.01). Furthermore, multivariate logistic regression showed that age (OR = 1.21 for each 5-year increase, 95% CI 1.09–1.35), sex (OR = 3.24 for female sex, 95% CI 1.82–5.76) and PWD (OR = 1.32 for each 10-ms increase, 95% CI 1.07–1.64) were the best subset of associated variables for severe ESUS.ConclusionsOur findings shed light on specific clinical characteristics of severe ESUS including the presence of atrial cardiopathy that could play a pathogenic role in this subgroup of patients. Searching for atrial fibrillation in these patients is especially important to perform the most appropriate therapy.
Effects of ω-3 Polyunsaturated Fatty Acids on Coronary Atherosclerosis and Inflammation: A Systematic Review and Meta-Analysis
Authors: Gao Zheng , Zhang Dewen , Yan Xiaocan , Shi Hekai , Xian Xiaohui 
Published: June 2022

Background and PurposeMultiple guidelines suggest the ω-3 polyunsaturated fatty acids (ω-3 PUFAs) help to prevent major vascular events of coronary heart disease (CHD), but the data on large trials of ω-3 fatty acids are controversial. We reviewed the available evidence to determine the effect of ω-3 PUFAs on coronary atherosclerosis.Materials and MethodsLiterature were from online databases. Randomized controlled trials (RCTs) or observational studies were acceptable. Quantitative data synthesis was conducted using R version 4.1.2. Each outcome was calculated using standardized mean difference (SMD) in a random-effect model. Sensitivity analysis was conducted for each outcome. A total of 21 RCTs and 1 observational study with 2,277 participants were included.ResultsMeta-analysis indicated a benefit of ω-3 PUFAs on coronary atherosclerosis, namely, (1) ω-3 PUFAs can reduce the atherosclerotic plaque volume (SMD −0.18; 95% CI −0.31 to −0.05); (2) ω-3 PUFAs can help reduce the loss of the diameter of the narrowest segments of coronary arteries in patients with CHD (SMD 0.29; 95% CI, 0.05–0.53); (3) ω-3 PUFAs do not have significant effect on volume of lipid plaque in coronary arteries (SMD −1.18; 95% CI −2.95 to 0.58), volume of fiber plaque (SMD 0.26; 95% CI −0.81 to 1.33), and calcified plaque (SMD 0.17; 95% CI −0.55 to 0.89); and (4) ω-3 PUFAs had no significant effect on endothelial inflammatory factors in peripheral blood.ConclusionsWe confirmed that ω-3 PUFAs benefit patients with CHD by reducing the progression of coronary atherosclerosis. We indicated that the benefits were not caused by reducing endothelial inflammations of coronary arteries.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021285139, identifier: CRD42021285139.
Contrast-Induced Acute Kidney Injury in Patients on SGLT2 Inhibitors Undergoing Percutaneous Coronary Interventions: A Propensity-Matched Analysis
Authors: Hua Rui , Ding Ning , Guo Hanqing , Wu Yue , Yuan Zuyi , Li Ting 
Published: June 2022

BackgroundContrast-induced acute kidney injury (CI-AKI) is a common complication of patients undergoing percutaneous coronary intervention (PCI). Data regarding the influence of sodium-glucose cotransporter-2 (SGLT2) inhibitor on the CI-AKI incidence and renal outcomes of patients undergoing PCI are limited. This study aimed to examine the real-world risk of CI-AKI in SGLT2 inhibitor users undergoing PCI.MethodsWe used longitudinal data from the medical records of the First Affiliated Hospital of Xi'an Jiaotong University. We selected SGLT inhibitor users and nonusers [patients with type 2 diabetes (T2D) without SGLT2 inhibitor prescription] undergoing PCI. We determined CI-AKI by the ESUR (European Society of Urogenital Radiology, AKIESUR) and KDIGO definition (Kidney Disease: Improving Global Outcomes, AKIKDIGO). We performed 1:1 nearest-neighbor propensity matching and calculated unadjusted odds ratios (ORs) and adjusted ORs (aORs; accounting for covariates poorly balanced) for AKI in primary and sensitivity analyses. We compared the renal function indicators in users and nonusers at 24, 48, and 72 h post-PCI.ResultsWe identified 242 SGLT2 inhibitor users and 242 nonusers in the cohort. The unadjusted ORs of CI-AKIESUR were 63% lower in users [OR: 0.37 (95% CI: 0.18–0.68); P = 0.01], which was unchanged [aOR: 0.37 (95% CI: 0.19–0.67); P &lt; 0.01] post adjustment. These estimates did not qualitatively change across several sensitivity analyses. There was no significant difference in urea nitrogen, creatinine, and estimated glomerular filtration rate (eGFR) values between the two groups before PCI, and at 24 h, while the creatinine (48 and 72 h post-PCI) and CyC (24 and 48 h post-PCI) were significantly lower than those in the nonuser group (P &lt; 0.05).ConclusionOur findings do not suggest an increased risk of CI-AKI associated with SGLT2 inhibitor use in patients with CAD and T2D undergoing PCI.
Sedimentary Rock Magnetic Response to Holocene Environmental Instability in the Pearl River Delta
Authors: Wu Yi , Fu Shuqing , Xiong Haixian , Zong Yongqiang , Ouyang Tingping , Peng Shasha , Cai Jianxin , Han Yulin , Zhu Zhaoyu 
Published: June 2022

Located on the northern coast of the South China Sea, the densely populated Pearl River Delta has experienced the combined effects of sea-level change, monsoon-driven discharge, and especially human activity, since the late Holocene. However, how these factors have regulated the regional environmental and sedimentary evolution remains unclear. To better understand these processes, we conducted a high-resolution rock magnetic investigation of the Holocene sediments of core DS01, drilled in the vicinity of the West River channel in the head area of the Pearl River deltaic plain. The magnetic grain-size proxy of the ARM/κlf ratio (the ratio of anhysteretic remanent magnetization to low-field magnetic susceptibility) indicates a long-term fining trend of the magnetite grain size, which may be a response to an increase in the weathering intensity in the Asian monsoon region during the Holocene. An interval with an enhanced concentration of magnetic minerals (mainly magnetite and hematite) occurred during 7.7–4.8 kyr BP (calendar years before 1950), coinciding with a period of delta progradation. During the marine transgression in the early Holocene, two similar intervals of magnetic enrichment may reflect regional hydrodynamic shifts associated with cooling events at ∼9.5–9.3 kyr BP and 8.2 kyr BP. The subsequent 4.2 kyr BP cooling event possibly induced a cold and dry environment in the sediment source area. From ∼800 yr BP onward, there was a major increase in the sedimentary magnetic mineral content, likely in response to intensified agricultural and industrial activities.
Prognostic Value of Triglyceride to High-Density Lipoprotein Cholesterol Ratio (TG/HDL-C) in IgA Nephropathy Patients
Authors: Pei Gaiqin , Qin Aiya , Dong Lingqiu , Wang Siqing , Liu Xiang , Yang Dandan , Tan Jiaxing , Zhou Xiaoyuan , Tang Yi , Qin Wei 
Published: June 2022

BackgroundThe triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio is an easy-to-use atherogenic and prognostic marker which has attracted increasing attention these days. However, whether TG/HDL-C correlate with outcomes in IgA nephropathy (IgAN) patients remains unknown. To clarify these issues, we conducted this study.MethodsA total of 1146 patients from West China Hospital of Sichuan University were retrospectively analysed between 2008 and 2018.The demographic, clinical and pathological data of all patients at the time of biopsy were collected. Then, patients were divided into the high TG/HDL group (TG/HDL ≥ 1.495, N=382) and the low TG/HDL group (TG/HDL-C &lt; 1.495, N=764) based on the optimal cut-off value of the TG/HDL-C using receive operating curve. Cox proportional hazard models and Kaplan–Meier curves were used to evaluate the renal outcomes of IgAN.ResultsThe median age of the patients was 33 (26-42) years, and 44.5% were men. By correlation analysis, we found that the TG/HDL-C ratio was negatively correlated with the eGFR (r = 0.250, P &lt; 0.001) but positively correlated with proteinuria (r = 0.230, P&lt; 0.001), BMI (r=0.380, P&lt;0.001) and serum uric (r =0.308, P&lt; 0.001). Patients with a higher TG/HDL-C ratio tended to have hypertension [odds ratio (OR), 1.987; 95% CI, 1.527-2.587; P&lt;0.001] and more severe pathologic lesions with tubular atrophy/interstitial fibrosis (OR, 1.610; 95% CI, 1.203-2.154; P=0.001). During a median follow-up period of 54.1 (35.6-73.2) months, a high TG/HDL ratio was strongly associated with worse renal survival in IgAN patients (log-rank: P &lt;0.001). Multivariate Cox analysis demonstrated that a high TG/HDL-C ratio (HR 1.775, 95% CI 1.056-2.798; P=0.029) was an independent predictive marker to ESRD.ConclusionIn this study, we addressed the importance of TG/HDL-C ratio as a predictive marker for IgAN progression.