bluuebunny/crossref_metadata_2025_split huggingface dataset:
ATF4 promotes brain vascular smooth muscle cells proliferation, invasion and migration by targeting miR-552-SKI axis
Authors: Feng Meina , Zhou Qin , Tu Wenxian , Wang Yunfeng , Du Yuanmin , Xu Kang 
Published: July 2022

BackgroundStudies have indicated vascular smooth muscle cells (VSMCs) played a crucial role in atherosclerosis and microRNAs (miRNAs) played key roles in biological functions of VSMCs. Whereas, the potential function and mechanism of miR-552 in VSMCs remains unclear. Our aim was to explore the role of miR-552 on VSMCs and underlying mechanism.Material/MethodsMTT assay and transwell assay were used to measure the proliferation, invasion, and migration of human brain VSMCs (HBVSMCs) and mice VSMCs (mVSMCs), respectively. Bioinformatics tools and luciferase assay were adopted to verify the association between miR-552 and SKI. Rescue experiments were employed to assess the interaction of miR-552 and SKI in modulating biological functions in HBVSMCs and mVSMCs. The expression level of transcription factors (TFs)was measured via qRT-PCR assay. The effect of ATF4 on miR-552 and SKI expression was tested by qRT-PCR or western blot assay. Finally, chromatin immunoprecipitation (ChIP) assay and JASPAR databases were used to analyze the regulatory linkage between ATF4 and miR-552.ResultsWe found that miR-552 was upregulated in HBVSMCs treated with PDGF-bb and miR-552 overexpression could promote proliferation, invasion, and migration of HBVSMCs and mVSMCs, whereas, miR-552 knockdown had the opposite impact. In addition, we also found that SKI was a direct target of miR-552, which reversed miR-552-mediated proliferation, invasion, and migration in HBVSMCs and mVSMCs. Furthermore, we also discovered that miR-552 overexpression promoted the effects of ATF4 elevation on proliferation, migration and invasion of HBVSMCs and mVSMCs, but, miR-552 decline had the opposite impact.ConclusionsATF4-miR-552-SKI axis played critical roles in the proliferation and migration of HBVSMCs and mVSMCs, which were closely involved in atherosclerosis (AS). Therefore, our findings might offer a novel therapeutic target for AS.
Visualizing Taste: How Business Changed the Look of What You Eat, Ai Hisano (2019)
Authors: Carbon Claus-Christian 
Published: July 2022

Review of: Visualizing Taste: How Business Changed the Look of What You Eat, Ai Hisano (2019)
Cambridge, MA: Harvard University Press, 336 pp., p/bk, $39.50
ISBN 978-0-67498-389-2
Endoscopic Findings of Gastric Cryptococcosis in an Immunosuppressed Patient
Authors: Flores Luis , Alvizuri Claudia , Ramirez Dania , Salas Yessenia , Ojeda Manuel 
Published: July 2022

ABSTRACT
A 34-year-old man with a recent HIV diagnosis presented to the emergency department with a holocranial headache and skin lesions due to cryptococcosis. He was admitted and during treatment, he presented nausea, persistent vomiting, and epigastric pain. Esophagogastroduodenoscopy revealed multiple round lesions with reddish elevated edges and a pale center in corpus and antrum which were positive for Cryptococcus in pathology analysis.
Mobile Instant Messaging Communication Etiquette: Educators’ Voices and Point of View
Authors: Permatasari Alfelia Nugky , Soelistiyowati Endang , Nugroho Vincentius Tangguh Atyanto 
Published: July 2022

Communication using digital media has highly increased since the pandemic, including within education context. Different types of expectation between the involved parties sometimes causing communication challenge for both. This study aims to find out how educators viewed the courtesy shown by the students during interactions using instant messaging media. Specifically, it aims to find out politeness indicators, communication challenges, and educators’ expectations. The interview questions included the concept of appropriate and polite messages between students as well as the overall attitudes of students within WhatsApp communication. The interviews are transcribed and coded based on what is listed in the framework. The results of the study reveal that most lecturers agreed students are adept in establishing communication through WhatsApp, compared to those in the past by incorporating greetings to open a conversation, stating identity, thanking and closing to end the conversation. Aside from a small number of students having trouble following etiquette, challenges appeared mostly when educators did not set clear rules on what they expected regarding WhatsApp communication. Educators have lower expectations on WhatsApp use in non-academic context.
CFD-based approach to design the heart-shaped micromixer with obstacles
Authors: Gidde Ranjitsinha R. , Pawar Prashant M. , Santana Harrson S. 
Published: July 2022

Abstract
Microfluidic devices/systems, including Micro-Total-Analysis-System (µTAS), Point of Care Testing (POCT) and Lab-On-a-Chip (LOC) are used in many chemical and biological assays applications. Among the vital tasks that these microfluidic devices must achieve essentially include a high degree of mixing and accordingly, micromixers are being used for the same purpose. The design depends on the yield required in particular application. In the proposed study, the four kinds of heart-shaped micromixers with different obstacles have been studied through simulations. The influence of the shape and size of different obstacles viz., circular shape, diamond shape, teardrop shape, and heart shape obstacles on the performance characteristics has been studied. The performance characteristics namely, the mixing index and pressure drop have been used. In accordance with the study, a heart-shaped micromixer with heart shape obstacles (HSM-HSO) has come out to be the most efficient micromixer due to the significant chaotic convection effect. The heart-shaped micromixer with heart shape obstacles (HSM-HSO) of size 0.350 µm × 0.350 µm has shown better performance for a wider range of Reynolds number (Re), i.e., mixing index of Re > 0.99, for Re of 0.1 and Re in the range of 15–45.
Tapered photonic switching
Authors: Galiffi Emanuele , Yin Shixiong , Alú Andrea 
Published: July 2022

Abstract
The advent of novel nonlinear materials has stirred unprecedented interest in exploring the use of temporal inhomogeneities to achieve novel forms of wave control, amidst the greater vision of engineering metamaterials across both space and time. When the properties of an unbounded medium are abruptly switched in time, propagating waves are efficiently converted to different frequencies, and partially coupled to their back-propagating phase-conjugate partners, through a process called time-reversal. However, in realistic materials the switching time is necessarily finite, playing a central role in the resulting temporal scattering features. By identifying and leveraging the crucial role of electromagnetic momentum conservation in time-reversal processes, here we develop a general analytical formalism to quantify time-reversal due to temporal inhomogeneities of arbitrary profile. We deploy our theory to develop a formalism, dual to spatial tapering, that enables the tailoring of a desired time-reversal spectral response, demonstrating its use for the realization of broadband frequency converters and filters.
Otogarden
Authors: Oliva Costantino , Poutiainen Ari 
Published: July 2022

In this article we present ludomusicological research associated with the development of the video game Otogarden. Players of Otogarden are able to repeat short musical phrases through the use of a loop mechanic, juxtaposing sounds extemporaneously. By using the methodology of research through design, Otogarden addresses aesthetic and design issues related to musical participation in video games. Specifically, this article argues that video games, a contemporary venue for technologically augmented musicking, can allow access to novel forms of musical improvisation. In fact, while video games afford a remarkable variety of musicking, examples related to musical improvisation remain underexplored, with popular games favoring score-based interactions, as established by titles such as Guitar Hero or Rock Band. In similar examples, music is presented as a task to be completed, mediated by prerecorded compositions and simplified notations. Notable exceptions, such as the experimental game Electroplankton, have been criticized specifically for their lack of composition-oriented functionalities, seemingly neglecting the inherent value of improvisatory musical practices in video games.
Otogarden challenges this understanding of a “music game” by focusing on the largely untapped potential of musical improvisation, “an activity of enormous complexity and sophistication, or the simplest and most direct expression.”1 In order to gain feedback on Otogarden’s special characteristics, we held a playtesting session with a sample of university students (N=21) with a special interest in music and music education. We collected research data from this session in the form of a survey. Analysis reveals different manifested perspectives, offering players novel creative opportunities. In addition, the game has surprising potential as a music-education tool. We conclude that it is possible to deliberately stimulate players’ perspective on the game in an improvisatory musical direction, making evident the extemporaneous musical possibilities connected with digital game engagement.
¿Discursos de moralidad o de racionalidad? La Iglesia Católica argentina frente a la despenalización del consumo de drogas (2009-2019)
Authors: Ferreyra Fausto Gabriel 
Published: July 2022

Objetivo: conocer en qué grado los discursos públicos de la Iglesia Católica presentan a la despenalización del consumo adulto de drogas desde un encuadre moral, sustentando su oposición con base en argumentos deontológicos, antes que a partir de un encuadre racional-instrumental centrado en exponer los problemas técnicos o prever las consecuencias concretas de la medida. Metodología: se combinan técnicas cualitativas y cuantitativas para efectuar un análisis sistemático de los argumentos expuestos por parte de referentes eclesiales entre 2009 y 2019. Resultados: el encuadre moral posee una presencia minoritaria entre los pronunciamientos de la Iglesia respecto a la despenalización. Conclusiones: aunque estos hallazgos coinciden con la hipótesis de secularización estratégica, los argumentos examinados muestran una pluralidad que excede al discurso científico o legal, registros a los que usualmente se ha visto recurrir al activismo religioso a la hora de expresarse públicamente respecto a esta clase de temas.
Rancang Bangun Model Diseminasi Informasi Kawasan Pariwisata Talaga Bodas Kabupaten Garut
Authors: Winoto Yunus , Zakiah Luthfi Gunarti , Anwar Rully Khaerul 
Published: July 2022

ABSTRAKKabupaten Garut merupakan wilayah di Jawa Barat yang memiliki banyak potensi wisata alam. Salah satu wisata alam yang ada di Kabupaten Garut adalah Talaga Bodas. Permasalahan yang muncul di kawasan Talaga Bodas masih belum dikenal secara luas oleh wisatawan dikarenakan diseminasi informasi yang masih minim dilakukan. Diseminasi informasi berperan penting dalam mempromosikan kawasan pariwisata Talaga Bodas agar dapat lebih dikenal oleh wisatawan. Tujuan dari penelitian ini untuk merancang bangun model diseminasi informasi Talaga Bodas. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan action research berdasarkan model Kurt Lewin terdiri dari perencanaan, tindakan, pengamatan, dan refleksi. Data penelitian diperoleh melalui hasil wawancara, observasi dan tindakan dokumentasi. Penelitian ini dilakukan dengan melalui 2 siklus. Hasil penelitian menunjukkan bahwa dari 2 siklus yang dilakukan menghasilkan media diseminasi dalam bentuk booklet khusus Talaga Bodas yang tersedia secara cetak dan online pada link berikut bit.ly/BookletTalagaBodas dan leaflet yang dirancang dalam bentuk pengembangan dari leaflet yang telah tersedia. Model diseminasi ini dapat menjadi salah satu cara mempromosikan kawasan pariwisata Talaga Bodas. Kata Kunci : model diseminasi informasi, kawasan wisata, promosi wisata, komunikasi. ABSTRACTGarut Regency is an area in West Java that has a lot of natural tourism potential. One of the natural attractions in Garut Regency is Talaga Bodas. The problems that arise in the Talaga Bodas area are still not widely known by tourists due to the lack of information dissemination. Information dissemination plays an important role in promoting the Talaga Bodas tourism area so that it can be better known by tourists. The purpose of this research is to design a model for the information dissemination of Talaga Bodas. The research method used is a qualitative method with an approach action research based on Kurt Lewin's model consisting of planning, action, observation, and reflection. Research data obtained through interviews, observation and documentation action. This research was conducted through 2 cycles. The results showed that the 2 cycles carried out resulted in dissemination media in the form of a booklet special Talaga Bodaswhich was available both in print and online at the following link bit.ly/BookletTalagaBodas and leaflets designed in the form of a development from existing leaflets . This dissemination model can be a way to promote the Talaga Bodas tourism area. Keywords: information dissemination model, tourist areas, tourism promotion, communication
The Influence of Hotel Employee Job Stress towards Cyberloafing
Authors: Wiastuti Rachel Dyah , Prawira Oqke , Yulianti Devi 
Published: July 2022

A b s t r a c tThe purpose of this research is to determine the influence of employee’s job stress towards cyberloafing at Four Seasons Hotel Jakarta. Primary data was collected through survey using questionnaire with five-point Likert scale and close-ended question. Sample of this research was 36 employees at Four Seasons Hotel Jakarta in back of the house departments. Data was analyzed with descriptive statistics, correlation, regression analysis, and three hypothesis testing using SPSS. The results indicate that job stress has significantly influenced on cyberloafing with a value of 11%. Job stress and cyberloafing have low correlation, but positive and significant. Furthermore, job ambiguity showed significant influence with cyberloafing, while job conflict showed the contrary of insignificant. It showed that employees tend to do cyberloafing when they felt uncertainty or ambiguity related to their job compared to the conflict that they encountered. From this findings, hospitality companies are expected to always assure that their employees perceived certainty related to their job tasks and job description to prevent any upcoming job stress.A b s t r a kPenelitian ini bertujuan untuk mengetahui pengaruh stres kerja karyawan hotel terhadap cyberloafing. Penelitian ini menggunakan metode kuantitatif. Data primer dikumpulkan melalui survei dengan menggunakan kuesioner lima poin skala Likert dan pertanyaan tertutup. Sampel dari penelitian ini berjumlah 36 karyawan dari empat departemen back of the house yang berbeda. Data dianalisis dengan deskriptif statistik, uji korelasi, analisis regresi linear sederhana, dan uji hipotesis dengan menggunakan SPSS. Hasil dari penelitian ini mengindikasikan bahwa stres kerja berpengaruh signifikan terhadap cyberloafing yaitu sebesar 11%. Hubungan antara stres kerja terhadap cyberloafing memiliki hubungan rendah namun positif dan signifikan. Selanjutnya ambiguitas pekerjaan menunjukkan pengaruh yang signifikan dengan cyberloafing, sedangkan konflik pekerjaan menunjukkan kebalikan yang tidak signifikan. Hal ini menunjukkan bahwa karyawan cenderung melakukan cyberloafing ketika mereka merasakan ketidakpastian atau ambiguitas terkait pekerjaan mereka dibandingkan dengan konflik yang mereka hadapi. Dari temuan ini, perusahaan perhotelan diharapkan untuk selalu memastikan bahwa karyawan mereka merasakan kepastian terkait dengan tugas dan deskripsi pekerjaan mereka untuk mencegah stres kerja yang akan datang.
COVID-19 infection in patients with chronic myeloid leukemia in the Orenburg region during the SARS-CoV-2 pandemic
Authors: Kuchma G. B. , Yakubova U. A. , Kozlova L. K. , Lebedenko S. A. , Sayfutdinov F. R. 
Published: July 2022

Background. Oncohematological patients are more predispose to SARS-CoV-2 infection than healthy individuals and patients with malignant neoplasms, and also they have a worse prognosis, which is because of immune system disorders, both due to the underlying disease and as a result of immunosuppressive therapy. There is limited data regarding the impact of SARS-CoV-2 infection on the survival of patients with chronic myeloid leukemia (CML).Aim. To evaluate the course and outcome of COVID-19 in patients with CML in the Orenburg region during the SARS-CoV-2 pandemic.Materials and methods. All 166 patients with CML over 18 years of age were analyzed during the COVID-19 pandemic between february 2020 and December 2021. The source of information was data from the personalized register of patients with CML and the unified state health information system.Results. The proportion of SARS-CoV-2 infection among patients with CML was 36 %. The risk of infection was not affected by age, gender, work features, place of residence, phase or duration of the disease, and therapy. underwent COVID-19 patients were 1.6 times more likely to be overweight and 2 times more likely to have a second cancer. A significant increase in the number of outpatient visits to polyclinics and number of hospital admissions during the pandemic was revealed in the group of patients who had SARS-CoV-2 infection. underwent COVID-19 patients were over 60 years of age in 48.3 % of cases and had one or more comorbidities in 77.6 % cases. SARS-CoV-2-infected patients with CML had a favorable outcome: a mild course of infection in 75.9 % of cases and a low mortality rate - 6.8 % (4 of 58 patients) were observed. COVID-19 was recognized as the cause of death in only 2 patients with optimal molecular response and comorbidity. In two other patients who underwent COVID-19, the progression of CML to a blast crisis was recognized as the cause of death. There were no significant differences in mortality level in the group of patients who had SARS-CoV-2 infection and those who did not have COVID-19.Conclusion. patients with CML living in the Orenburg region have a low susceptibility to SARS-CoV-2 infection and a mild course of the disease. The mortality rate for CML patients infected with SARS-CoV-2 was 6.8 %. unfavorable factors in the overall survival of patients with CML infected with SARS-CoV-2 were high comorbidity and blast crisis. Reducing the number of outpatient visits during the pandemic and using remote medical consultations is likely to reduce the risk of SARS-CoV-2 infection.
According to the materials of the Conference “Algorithms of emergency situations in oncohematology. Approaches and treatment”
Authors: Ryabukhina Yu. E. 
Published: July 2022

В Онкологическом центре Клинического госпиталя «Лапино» группы компаний «Мать и дитя» 10 сентября 2021 г. состоялась конференция, посвященная тактике ведения пациентов с онкогематологическими заболевани ями в ургентных клинических ситуациях.На конференции с докладами выступили не только ведущие российские онкологи и гематологи, но и врачи других специальностей (по поддерживающей терапии, инструментальной диагностике, анестезиологи-реаниматологи, акушеры-гинекологи, патоморфологи).Были освещены самые актуальные вопросы диагностики и лечения пациентов в тех случаях, когда незамедлительная правильно выбранная тактика может способствовать благоприятному прогнозу.
Combined immunochemotherapy in patients with refractory/relapsed classical Hodgkin's lymphoma as a 2<sup>nd</sup> line treatment before autologous hematopoietic stem cell transplantation (preliminary results)
Authors: Mamedova A. A. , Mochkin N. E. , Sarzhevskiy V. O. , Demina E. A. , Bogatyrev V. S. , Spornik A. A. , Samoylova A. A. , Rukavitsin A. A. , Smirnova E. G. , Bannikova A. E. , Melnichenko V. Ya. , Mikhaylova N. B. , Borzenkova E. S. , Stelmakh L. V. , Zalyalov Yu. R. , Semenova A. A. , Tumyan G. S. , Danilova M. A. , Konova O. A. , Falaleeva N. A. , Terekhova A. Yu. , Vernyuk M. A. , Chervontseva A. M. , Khayrullina L. S. , Maslov A. A. , Lysenko I. B. , Alekseeva Yu. A. , Pavlyuchenko E. S. , Mirsaitov A. A. , Zverkova A. A. , Ishmatova I. V. , Volchenkov S. A. , Motalkina M. S. , Zyuzgin I. S. 
Published: July 2022

Aim. To study the efficacy and safety of combined immunochemotherapy according to the DHAp protocol + nivolumab in patients with refractory/relapsed classical Hodgkin's lymphoma before autologous hematopoietic stem cell transplantation.Materials and methods. The study consisted of 2 phases: 1st - immunotherapy with nivolumab (2 injections as monotherapy at a dose of 240 mg/day with 14 days interval); 2nd - combined immunochemotherapy according to the DHAp protocol + nivolumab (14 days after the 2nd administration of nivolumab): nivolumab 480 mg/day on day 1 in combination with chemotherapy according to the DHAp protocol, 4 cycles in total. The effectiveness of therapy was evaluated after 2 injections of nivolumab, after 2 and 4 cycles of combination therapy. from March 2020 to November 2021, 32 patients were included in the study. The median age was 34 (18-55) years.Results. As of November 2021, the result was evaluated in 32 patients after the 1st stage of treatment (nivolumab monotherapy). A complete response was obtained in 4 (12.5 %) patients, a partial response in 20 (62.5 %) patients, disease stabilization was noted in 5 (16 %) patients, an indeterminate response in 3 (9 %) patients. At the 2nd phase, the efficacy after the 2nd cycle of DHAp + nivolumab was evaluated in 31 patients (complete response was obtained in 19 (61 %), partial response in 11 (36 %)); the final efficacy evaluation (after the 4th cycle of DHAp + nivolumab) was performed in 30 patients, and all patients achieved response to therapy (complete response in 25 (83 %), partial response in 5 (17 %)). 2 patients were excluded from the study.Conclusion. preliminary results of combined immuno- and chemotherapy according to the DHAp protocol showed high efficacy and relatively low toxicity in patients with refractory/relapsed classical Hodgkin's lymphoma before autologous hematopoietic stem cell transplantation.
Neutrophilic hyperleukocytosis in the multiple myeloma onset
Authors: Rekhtina I. G. , Kolosova L. Yu. , Khyshova V. A. , Kovrigina A. M. , Mendeleeva L. P. 
Published: July 2022

Neutrophilic leukocytosis is not specific for multiple myeloma (MM) and is a reason for the exclusion of myeloproliferative neoplasm.A clinical case of MM patient with neutrophilic hyperleukocytosis (75 х 109/L), liver and spleen enlargement at the disease onset is presented. Examination did not reveal t(9;22), BCR/ABL gene and JAK2V617F mutation. To exclude the combination of MM with chronic neutrophilic leukemia, a study of the clinically significant part of the CSFR3R gene was performed. The absence of a CSFR3R gene mutation made it possible to exclude chronic neutrophilic leukemia and start MM treatment. After the 1st therapy course with bortezomib, cyclophosphamide and dexamethasone, blood counts returned to normal, liver and spleen size decreased. After 6 therapy courses, complete hematological remission was achieved. An attempt to mobilize peripheral blood stem cells with cyclophosphamide was unsuccessful. The effectiveness of antimyeloma therapy proved the correctness of the diagnosis and the chosen treatment tactics.Neutrophilic leukocytosis in MM is explained by the ability of plasma cells to synthesize granulocyte colony-stimulating factor in some cases. In the presence of a plasma cell tumor, the analysis of the CSFR3R gene may be of decisive importance in the differential diagnosis of reactive neutrophilic leukocytosis due to MM and the combination of MM with chronic neutrophilic leukemia.