bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wettability Alteration with Weak Acid Assisted Surfactant Flood
Authors: Shi Yue , Niu Fangya , Mohanty Kishore 
Published: September 2022

Abstract
Oil-wetness and heterogeneity are two key reasons for low oil recovery by waterflooding in carbonate reservoirs. Surfactants have been effective in altering oil-wet matrix to a more water-wet condition and initiating spontaneous imbibition. Because it takes time for surfactant to alter wettability, oil recovery from the tight matrix is considered to be slow and sometimes not economically feasible. Acids have a potential of dissolving minerals, which may alter wettability. In this study, the EOR performance of acid-assisted surfactant water was evaluated for both low- and high-temperature applications. A set of acids and their acetates were tested. Bulk rock-acid reaction, wettability alteration (WA) tests and spontaneous imbibition measurements were conducted at both 35°C and 80°C to identify effective candidates. Coreflood tests were then performed to evaluate the selected acid-surfactant formulations. Before and after coreflood test, the core was scanned in a micro-CT to investigate pore structure alteration. Bulk reaction measurements showed that weak acids, especially acetic acid (AA), have the desired low reaction rates at 35°C. At 80°C, acetates exhibited a slow reaction. WA tests showed that, at 35°C, AA can remove the crude oil off the rock surface and alter wettability. Acetates showed wettability alteration potentials at 80°C. Spontaneous imbibition experiments showed that AA-surfactant solution results in the highest oil recovery at 35°C. Acetate-surfactant showed a high oil recovery and a long equilibrium time at 80°C. Coreflood tests showed that adding AA into surfactant water can significantly improve oil production and its rate through mineral dissolution and wettability alteration. Micro-CT showed that minerals were transported along the core and plugged vugs, which reduced permeability and diverted flow leading to improved oil recovery.
Stimulation Efficiency with Significantly Fewer Stages: Perforation Strategy Combined with Multimodal Diverters and Novel Nonintrusive Monitoring Algorithm
Authors: Alobaid Hashem , Khan Abdul Muqtadir , Hansen Jon , Khudorozhkova Aleksandra 
Published: September 2022

Abstract
Tight carbonate development is moving towards longer laterals requiring a higher number of fracturing stages to complete a given well. A higher stage count implies longer completion time and higher costs. Therefore, an engineered strategy using technology enablers is indispensable to reducing the number of stages while retaining the well performance objective.
A 6,250-ft cemented lateral initially planned with 13 fracturing stages was analyzed for lithology and reservoir development to revise the perforation strategy to complete with more clusters per stage and reduced the number of stages to 5 stages. Clusters were designed to be very narrow to effectively divert the fracture fluids using chemical diversion. For a successful stimulation evaluation, a novel pressure monitoring technique was used to analyze the fluid entry points from the water hammers.
Pills of multimodal particulate near-wellbore diverters were used across the lateral to stimulate the perforated clusters in only five fracture stages effectively. The multimodal particle distribution model allows for bridging and then creating an impermeable flow barrier to ensure diversion. Effective diversion was seen through a pressure increase when diverter entered the formation. Correlations were analyzed for diversion pressure dependence on pill volume and injection rate to improve diversion. A new algorithm for nonintrusive diagnostics was also deployed. The algorithm combines advanced signal processing with a tube wave velocity model based on Bayesian statistics and has no additional operational footprint. The program allowed a timely interpretation to evaluate the fluid entry points based on the water hammer events. This evaluation was compared to the intuitive stimulation sequence based on the lithology to explain the results. The comprehensive analysis demonstrated the lateral was stimulated effectively. Finally, the production performance was compared with two offset horizontal wells intersecting the same carbonate sublayer. Offset 1 was a cemented lateral completed with 12 stages, and offset 2 was an openhole packer and sleeve lateral completed with 7 stages. Analysis of the post-fracturing absolute production enhancement showed 11 to 15% improvement and production index (PI) improvement was 40 to 63% when normalized by stage count.
The paper presents a rare and unique strategic integration of multiple technologies. This success paves the way for similar future developments to enhance operational efficiency and allow significant cost savings.
A New Folding Motif Formed with an Expanded Genetic Alphabet
Authors: Benner Steven , Wang Bang , Rocca James , Hoshika Shuichi , Chen Cen , Yang Zunyi , Esmaeeli Reza , Wang Jiangguo , Pan Xiaoshu , Lu Jianrong , Wang Kevin , Cao Y. Charles , Tan Weihong 
Published: September 2022

Abstract

Adding nucleotide pairs to a DNA alphabet not only increases the linear information density of DNA molecules, but also may increase the diversity of folds available to the molecular system. Reported here is an example of this. A single additional nucleotide, with the 5-nitro-6-aminopyridone ("Z") heterocycle, selected from an artificially expanded genetic information system (AEGIS), was incorporated at twelve sites into a DNA strand 23 nucleotides in length. With a fluor at its 5'-end and a quencher at its 3'-end, this molecule is shown by fluorescence quenching to fold in mildly alkaline (pH 8-9) conditions. This folded structure is quite stable, melting at Tm = 66.5 ℃ at pH 8.5. Spectroscopic, gel, and 2-dimensional NMR (800 MHz) analyses show that the structure is held together by "reverse" Z-:Z base pairs, which have been previously seen in a crystal structure of the free heterocycle, 5-nitro-6-aminopyridone. This, in turn, requires that the strands joined by Z-:Z reverse pairs be oriented in parallel. This, in turn, requires the fold to have a four stranded compact "down-up-down-up" fold. The structure does not form when various Zs are replaced or scrambled. Of two possible structures, we also considered the possibility of "intercalated" Z-:Z base pairs, a fold that resemble the i-motif of standard DNA where an analogous "down-up-down-up" fold is held together by C:C+ pairing at lower pH between parallel strands. An alternative model has a "down-up-down-up" fold without intercalation.
Control of Aedes mosquito by targeting dengue fever virus in local mosquito population
Authors: Sarwar Imtiaz , Riaz Muhammad Asam , Iftikhar Sohaib , Baig Mirza Bilal , Ali Zulfiqar , Afzal Muhammad , Majeed Muhammad Zeeshan , Ullah Muhammad Irfan 
Published: September 2022

Abstract
Mosquitoes are causing plenty of diseases including dengue fever, malaria, japanese encephalitis. Mosquitoes were collected from 1006 sties of six tehsils of district Sargodha. Different containers were inspected for mosquito sampling. RNA was extracted from female mosquitoes and used for cDNA synthesis followed by detection of arbovirus using primer. The site index (SI) and tehsil container index (TCI) of district Sargodha was 28.3 and 12.2 respectively. Overall, the percentage of Aedes spp, Culex spp. and Anopheles spp was 79, 20 and 0.4% respectively, in the collected population. Highest positive containers for Aedes mosquitoes were discarded tires. Overall, 12.2% of containers were found positive for mosquito population. Maximum number of larvae and adults were recorded from urban area of district Sargodha (SgdU). Arboviruses, Flavivviruses, were found in 5 pools (almost 3%) of the samples, while, other viruses such as Alphaviruses and Bunyaviruses were not detected in any of the samples. Man-made habitats are the main contributors to dengue fever mosquito population. There is a dire need of proper environment management to reduce the breeding places of mosquito and detect the virus in local population for environmental friendly control of dengue fever mosquito.
OAM-GANN: Online Adaptive Memory based Genetically optimized Artificial Neural Network for PUEA Detection in CRN Applications
Authors: Robert V Noel Jeygar , Vidya K 
Published: September 2022

Abstract
Cognitive Radio Networks (CRNs) allows opportunistic usage of spectrums owned by licensed users or primary users (PUs). The unlicensed users or secondary users (SUs) that use the spectrum rely opportunistically on spectrum sensing to determine the presence of PU signal. Unfortunately, this attribute opens the door for attacks such as the as the Primary User Emulation Attack (PUEA). This attack happens when an attacker emulates a PU signal. The intention of the attacker might be to grab the vacant channels for its data transmission or entirely disrupt the working of the CRN. Hence it is necessary to combat the consequences of PUEA effectively. Artificial Intelligence (AI) has shown its excellence in various applications including the detection of PUEA. To further enhance the security of the CRN, this research work proposes a novel classification framework called Online Adaptive Memory based Genetically optimized Artificial Neural Network (OAM-GANN) which introduces adaptive online learning of network parameters to identify the presence of PUEA. The proposed OAM-GANN involves Computational Intelligence (CI) algorithm called Memory based Genetic Algorithm (MGA) to optimally tune the hyperparameters of the developed ANN. The advantages of online adaptive training and optimal hyperparameter tuning of the AI model, result in improved security to the network and the data being transmitted in the CRN. The performance of the proposed attack detection model is evaluated in terms of accuracy, sensitivity, specificity, error rate, and detection probability. In addition, the performance of the proposed secure CRN is evaluated in terms of throughput and packet delivery ratio.
Isolated and Combined Effect of Hydraulic and Ladder Training on TCL, LDL and HDL Cholesterol Among College Women Students
Authors: Karthikeyan K.Manosakthi , Kalimuthu K.Divya 
Published: September 2022

Abstract
Background
The body's potential for characteristic; health became visible as a state of regular function that would be disrupted from time to time through disorder. The purpose of this study was to determine the isolated and combined effect of hydraulic and ladder training on total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol among college women students.
Methods
Totally 60 untrained volunteers from KAHE were taken to participate in the study. Their age ranged from 18 to 24 years. They were randomly divided and assigned into three groups of fifteen each as the experimental group (hydraulic training) 1(n = 15), experimental group (ladder training) 2 (n = 15), experimental group (hydraulic and ladder training) 3(n = 15) and control group 1 (n = 15). The data were collected before and after the training period of 12 weeks and the data collected were statically analysed which was used to find out the significant improvement on selected parameters and analysis of variance (ANOVA) was used to find out the significant difference if any among the adjusted post-test means of the experimental and control group on each parameter separately.
Results
The Statistical analysis of the hydraulic training group, ladder training group, combined training group, and the control group of F ratio. The obtained f ratio of total cholesterol is 41.01, low-density lipoprotein is 40.44 and high-density lipoprotein cholesterol is 31.59 of post-test was greater than the table value of the degree of freedom 3,56 required for the significance at 0.05 level. The combined training group responded to the training with a more positive influence on low-density lipoprotein, and high-density lipoprotein cholesterol, when compared with the hydraulic training group, ladder training group, control group, and the hydraulic training group, the ladder training group was better than the control group.
Conclusion
It concluded that the study significantly improved that the combined training of hydraulic and ladder training was a better improvement in their level of total cholesterol, low-density lipoprotein, and high-density lipoprotein cholesterol and enhance their daily activity level of fitness also improved and better lifestyle.
Multifaceted analysis of cross-tissue, cross-sectional and longitudinal transcriptomes reveals phenotype–endotype associations in atopic dermatitis.
Authors: Koseki Haruhiko , Sekita Aiko , Kawasaki Hiroshi , Fukushima-Nomura Ayano , Yashiro Kiyoshi , Tanese Keiji , Toshima Susumu , Ashizaki Koichi , Miyai Tomohiro , Yazaki Junshi , Kobayashi Atsuo , Namba Shinichi , Naito Tatsuhiko , Wang Qingbo , Kawakami Eiryo , Seita Jun , Ohara Osamu , Sakurada Kazuhiro , Okada Yukinori , Amagai Masayuki 
Published: September 2022

Abstract
Atopic dermatitis (AD) is a skin disease heterogeneous both in terms of clinical manifestations and molecular profiles. It is increasingly recognized that AD is a systemic rather than a local disease and should be assessed in the context of whole-body level biology. In this study, we integrated RNA-seq data of both skin and PBMC along with clinical data from 115 AD patients and matched 14 healthy controls aiming to comprehensively capture the molecular signature associated with specific clinical presentation. Analysis of cross-tissue ligand-receptor coupling suggested increase of skin-PBMC interactions in AD patients compared to healthy controls. We built a regression model that predicts clinical phenotypes of AD using transcriptome modules identified from weighted gene co-expression network analysis of RNA-seq data in skin tissue and PBMC. We identified differential immunological signatures associated with two qualitatively differential skin manifestations of AD, erythema and papulation. Furthermore, we applied the regression model established in the cross-sectional dataset to a longitudinal dataset collected monthly from 30 AD patients for up to a year for personalized monitoring of disease trajectory and examined longitudinal heterogeneity in association with clinical presentation. Three patient clusters identified on the basis of longitudinal features of blood tests and PBMC transcriptome modules were found to be associated with longitudinal features in clinical severity as well as in the medication history. Our approach serves as a framework for effective clinical investigation to gain a holistic view of pathophysiology of complex human diseases by highlighting inter- and intra- patient heterogeneity.
Time Synchronous Averaging Based on Cross-power Spectrum
Authors: Wang Ling , HU Minghui , Ma Bo , Jiang Zhinong 
Published: September 2022

Abstract
Periodic signals produced by rotating machinery is of great significance for its fault diagnosis and health monitoring. Time synchronous averaging is an effective and convenient technique for extracting those components. However, the performance of time synchronous averaging is seriously limited when the separate segments are poorly synchronized. In order to address this problem, a new averaging method that is capable of extracting periodic components without external reference and accurate period is proposed in this paper. With this approach, the phase differences of all segments can be basically eliminated by phase detection and compensation. Therefore, the segments to be averaged have a high synchronization. The efficiency of this method is validated by numerical simulation and experimental investigation. The proposed method can improve the adaptability of time synchronous averaging.
Construction of Shellac-Based Drug Delivery System with Controlled Drug-release and Tunable Intragastric Floating-retention Properties
Authors: Yuan Ziting , Sun Bin , Li Kai , Tang Wei , Xu Juan 
Published: September 2022

Abstract
Intragastric floating-retention drug delivery system (IFRDDS) could prolong intragastric retention time and increase drug absorption to improve clinical efficacy and bioavailability effectively. To avoid the potential harm of synthetic materials, more biomass materials are used to synthesis the IRFDDS. In this research, shellac and its self-assembly behavoir triggered by H+ were employed to fabricate a continuous network for the matrix of IFRRDS. The NaHCO3 and HPMC acted as an effervescence agent and a precipitating agent, a positive agent and a negative agent for floating, respectively, which could create a porous structure for lowering the density of the tablet and continuously absorb water to enhance the density of tablet. Interestingly, the synergistic effect of NaHCO3 and HPMC was beneficial for initiating the floating of the complex tablet. By regulating their constitution, we could tune the floating lag time, continuous floating time and drug-release behavior of the shellac-based complex tablet. For example, the drug releasing curve of the shellac-based tablet containing 3wt% HPMC and 10wt% NaHCO3 presented a typical linear model, which was an ideal drug releasing system. Therefore, we successfully employed a facile strategy to fabricate a biobased IFRRDS with controlled drug-release and tunable intragastric floating-retention properties.
No Role for Electroencephalogram in the Initial Work-Up of Pediatric Acute Lymphoblastic Leukemia
Authors: Barnbrock Anke , Luesebrink Natalia , Schubert-Bast Susanne , Bochennek Konrad , Lehrnbecher Thomas 
Published: September 2022

Abstract
Purpose
The purpose of this study was to verify whether there is a prognostic benefit of electroencephalogram (EEG) performed during initial work-up of children with newly diagnosed acute lymphoblastic leukemia (ALL)
Methods
In a retrospective monocenter study, the value of electroencephalogram (EEG) performed during initial work-up of children with newly diagnosed acute lymphoblastic leukemia (ALL) was analyzed. All pediatric patients diagnosed with de novo ALL in our institution between January 1, 2005, and December 31, 2018, in whom an EEG was performed for initial work-up within 30 days of diagnosis, were included in the study and the occurrence and etiology of seizure activity during time of cancer treatment investigated.
Results
Out of 242 children, EEG revealed pathological findings in 6 patients. Two of them developed a seizure at a later time point due to adverse effects of chemotherapy, whereas 4 children had an uneventful clinical course. In contrast, 18 patients with normal initial EEG findings developed seizures during therapy for different reasons.
Conclusion
We conclude that routine EEG does not predict seizure susceptibility in children with newly diagnosed ALL and is unnecessary in the initial work-up as EEG investigation in young and often sick children requires sleep deprivation and/or sedation, and our data demonstrate no benefit in predicting neurological complications.
Synthesis, antifungal activity, and DFT calculation study of novel 1-acyl-5- amino-1,2,4-triazole-thioether derivatives containing natural gem-dimethylcyclopropane ring structure
Authors: Cui Yucheng , Lin Guishan , Duan Wengui , Wu Xiaocui , Wu Kaiyue , Li Baoyu 
Published: September 2022

Abstract
A series of novel 1-acyl-5-amino-1,2,4-triazole-thioether derivatives containing natural gem-dimethylcyclopropane ring structure were synthesized from natural biomass resource 3-carene. Their structures were confirmed by FT-IR, NMR, ESI-MS, and elemental analysis. The possible mechanism of regioselectivity for the N-acylation reaction of 5-amino-1,2,4-triazole with intermediate 4 was explored by DFT theoretical calculation. All the title compounds were evaluated for antifungal activity in vitro against eight plant pathogens, and some target compounds showed good inhibitory activity against the testedpathogens. For example, compounds 7f and 7g exhibited inhibitory rates of 81.6% and 80.9% against C. arachidicola, and A. solani, respectively, better than that of the commercial fungicide thifluzamide with corresponding inhibitory rates of 75.0% and 78.6%. Besides, against G. zeae, most of the target compounds displayed better antifungal activity than the positive control thifluzamide.
Research on the influence factors of thin-walled 5A02 aluminum alloy Y-shaped tube in the hydroforming based on differential lubrication.
Authors: Xu Jiajun , Xu Xuefeng , Fan Yubin , Xiao Jie , He Ruirui , Zhang Ju 
Published: September 2022

Abstract
In this paper, the effects of the lubrication method, the end face angle of the middle punch and its back pressure on the wrinkling and cracking during the hydroforming of the Y-shaped tube were discussed.It is of great significance to the hydroforming of thin-walled 5A02 aluminum alloy Y-shaped tube with large transition fillet that are asymmetric in both longitudinal and transverse directions. MoS2 and PTFE film were used to lubricate different areas of the Y-shaped tube. Designed end face Angle of 0° and 13.5° for middle punch. Constructed a stepped pressure-feed loading path.The test results show that the combination of MoS2-PTFE film only lubricated the bulging zone and partial back zone of the Y-shaped tube and didn’t lubricate other zones, which could effectively increase the flow rate of material in the expansion zone and prevent the main tube from wrinkling. Using the 13.5°middle punch with a back pressure of 7MPa and a stepped-increasing pressure-feed loading path could not only effectively suppress the cracking of the branch tube in the early stage of forming, but also obtain the ideal branch tube height and surface.
YKL-40: a potential prognostic predictor of one-year clinical outcomes in patients with acute ischemic stroke
Authors: Shi Guomei , Li Minghao , E Yan , Zhou Junshan , Wang Meng , Gong Pengyu , Wang Xiaorong , Lu Jingye , Wu Weixiang , Xue Shouru , Zhou Rujuan 
Published: September 2022

Abstract
YKL-40 mediates vascular inflammation and plays a crucial role in the pathogenesis of acute ischemic stroke (AIS). Previous studies have identified YKL-40 as a potential diagnostic biomarker for AIS. However, in patients with AIS, the effects of YKL-40 on long-term clinical outcomes including poor clinical outcome, all-cause mortality, and stroke recurrence remained elusive.The purpose of this study was to explore the association between serum YKL-40 at admission and one-year clinical outcomes in AIS patients. In this prospective cohort study, a total of 1002 participants out of 1361 AIS patients from two centers were included for current analysis. Serum YKL-40 concentrations were measured via enzyme-linked immunosorbent assay. Multivariable logistic or Cox regression were performed to explore the independent association of YKL-40 with one-year clinical outcomes, including poor outcome (modified Rankin Scale of 3-6), all-cause mortality, and recurrent stroke. C-statistic, net reclassification index (NRI) and integrated discrimination improvement (IDI) were calculated to evaluate the discriminatoryand predictive power of YKL-40 when added to conventional model. Compared with the first quartile of YKL-40, the adjusted odds ratios or hazard ratios (95% CI) of the fourth quartile was 3.032 (1.627-5.650) for poor outcome, 2.886 (1.320-6.308) for all-cause mortality and 1.694 (0.906-3.169) for recurrent stroke. The addition of serum YKL-40 to conventional model significantly improved reclassification for poor outcome (NRI 0.053, P = 0.031; IDI 0.018, P = 0.001) and all-cause mortality (NRI 0.162, P = 0.036). In conclusion, elevated serum YKL-40 at baseline might be independently associated with one-year poor outcome and all-cause mortality but not stroke recurrence among Chinese AIS patients, suggesting that YKL-40 can potentially serve as a valuable prognosticbiomarker for AIS.