bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Anti-epileptic Drugs for Post Traumatic Seizure: A Global Survey
Authors: Gopalan Harison , P Krishnakumar. , S Arun. 
Published: September 2022

Background Post traumatic seizures (PTS) and post traumatic epilepsy (PTE) are potential consequences of traumatic brain injury (TBI). There is no consensus regarding its management among treating doctors. Purpose We have undertaken a global survey to assess the variability of management practices of PTS and PTE and highlight the pressing need to formulate uniform practice guidelines. Methods A questionnaire consisting of sixteen questions were developed with the help of Google survey and sent through e-mail, or social media platforms like WhatsApp, Facebook messenger or Telegram, to practicing Neurologists and Neurosurgeons round the world. Results There were a total of 220 responses. Majority of our responders (n = 202; 91.8%) would start an anti-epileptic (AED) prophylaxis to prevent PTS; 18 people (8.18%) told that they would not start AED prophylaxis for TBI. Phenytoin (n = 98; 48.5%) followed by Levetiracetam (n = 78; 38.6%) was the preferred drug, although the latter was significantly preferred by high and upper middle-income countries ( p<.001). Majority (n = 99; 49%) would not use it beyond two weeks. Most clinicians would manage PTE with a single drug (n = 160; 72.7%) either Phenytoin (n = 69; 31.3%) or levetiracetam (n = 67; 30.4%). Most of them (n = 174; 86%) would treat for less than one year. Conclusions Practices in the management of PTS and PTE vary widely among clinicians. Our study point towards the need for the development of a more robust and comprehensive practice guidelines for the management of the same.
Hydrophobic and oleophilic 3D weft-knitted spacer fabrics coated by silica aerogels with five different concentrations
Authors: Islam Syed Rashedul , Patoary Mohammed Kayes , Estifanos Hewan Dawit , Lugoloobi Ishaq , Yousif Alrayah HD , Jiang Jinhua , Shao Huiqi 
Published: September 2022

Silica aerogels were made from tetraethylorthosilicate by the sol-gel method and coated on the 3D weft-knitted spacer fabrics (WKSFs) to compare the interaction of the silica aerogel coating with five various concentrations. SEM, FTIR-ATR, surface roughness, surface energy, and BET analysis were used to observe and characterize the surface morphology, molecular interaction, surface changes, surface tension, and specific surface area of fabric samples or sorbents. Consequently, this study investigated the wettability, oil absorption capacity, oil retention capacity, and reusability of untreated and treated 3D WKSF sorbents. The outcomes exposed the excellent hydrophobic and oleophilic properties of all treated 3D WKSF sorbents, showing a greater water contact angle of 145.1 ± 0.42°, and an oil absorption and retention capacity of (7.87 ± 0.09 g/g and 7.53 ± 0.06 g/g) and (89.98 ± 0.79% and 92.48 ± 0.56%) for vegetable oil and engine oil, respectively, with notable reusability, most particularly for sorbent 5, due to the higher silica aerogel add-on %, pore diameter, and pore volume. The findings verified that the chemical composition and fabric structure played an important role in the tremendous hydrophobic and oleophilic behavior. The statistical study on specific surface area, pore diameter, pore volume, surface roughness, water contact angle, oil contact angle, oil absorption capacity, and oil retention capacity also revealed that treated fabrics performed significantly ( p < 0.05) in hydrophobic and oleophilic features at the 0.05 level. Hence, these fabrics can be used in industrial usages that need hydrophobic and oleophilic qualities.
Role of Laser Pointer in Budgeting Fluoroscopy-Time and Radiation Exposure
Authors: Hong Tom , Hones Keegan M. , Ballard Brooke , Dell Paul C. , Wright Thomas W. , Matthias Robert C. 
Published: September 2022

Background: Literature on radiation exposure with use of the mini C-arm and value of having built-in laser guidance is limited. The purpose of this study was to determine whether laser guidance use on a mini C-arm fluoroscopy unit can reduce radiation exposure. Methods: Surgeons (N = 25) performed the same simulated surgical task, which involved obtaining “perfect circle” views of 2 cannulated screws placed into a cadaveric wrist, done with and without C-arm laser guidance. The testing order was randomized. Main outcomes were time to complete the task, number of shots required to complete the task, number of blank shots taken, radiation exposure, total dose area product (DAP), and total exposure time. Results: Laser guidance significantly reduced the percentage of surgeons who took blank shots, from 88% of the group without the laser to 12% of the group with the laser, and decreased the total average blank shots in the group from 3.5 to 0.1. While we found laser guidance led to shorter time to complete the task, decreased shots taken, and decreased exposure time and DAP, these findings only approached significance. Conclusion: While debate continues regarding whether mini or standard C-arm is safest, it is clear that decreasing the overall number of exposures limits potential adverse effects. Our study demonstrated that when using a mini C-arm, laser guidance decreases the number of exposures required to capture an image. These findings warrant a larger study to define the specific exposure savings and indicate potential benefit of mini C-arm use with laser guidance.
Endovascular treatment for M3 occlusions
Authors: Ozdemir Gokhan , Eren Alper , Aygul Recep , Eren Fettah , Kizildag Nazım , Kocaturk Idris , Mammadi Azer , Ersoy Ayse Nur , Korez Muslu Kazım 
Published: September 2022

Introduction Endovascular treatment (ET) is a beneficial treatment for M1–2 occlusions of the middle cerebral artery. Mortality and disability rates are high if large vessel occlusions are not treated. While these rates are lower in M3 occlusions, important branch blockages can lead to disability. Endovascular treatment of small vessel occlusions is difficult, and there are no studies on the effectiveness of endovascular treatment for M3 occlusions. Accordingly, in this study, our aim was to assess the feasibility, safety, and preliminary efficacy of endovascular therapy for M3 occlusions. Methods This study involved a retrospective analysis of a prospectively collected from two centres for acute ischemic stroke of the anterior system between July 2015 and April 2020. Demographic, radiologic, procedural and outcome variables were collected for patients who underwent endovascular therapy for acute ischemic stroke of the anterior system. Results Complete or near complete reperfusion (mTICI 2b-3) of the M3 occlusion was achieved in 15 cases (38.5%). Complete (mTICI 3) reperfusion was achieved in 24 cases (61.5%). Twenty-six patients were treated for primary M3 occlusion, while 13 patients with M3 occlusion were treated as a rescue strategy after successful treatment of a proximal greater vascular occlusion. Complete or near complete reperfusion (mTICI 2b-3) of primary occlusion was achieved in eight cases (30.8%), and complete (mTICI 3) reperfusion was achieved in 18 cases (69.2%). In addition, complete or near complete reperfusion (mTICI 2b-3) of rescue M3 occlusion was achieved in seven cases (%53.8), while complete (mTICI 3) reperfusion was achieved in six cases (46.2%). Only one patient with primary M3 occlusion had ICH due to extravasation. The patient's neurological examination one month later was normal. Conclusions This retrospective study demonstrates that endovascular treatment of M3 occlusions is safe, effective and reliable.
Differences in beginner and expert neurointerventionalists” heart rate variability during simulated neuroangiographies
Authors: Hinzmann Dominik , Singer Maximilian , Schmelter Valerie , Kreiser Kornelia , Gehling Kim , Ströber Lea , Kirschke Jan S , Schulz Christian M , Schneider Frederick 
Published: September 2022

Background Likewise work experience, heart rate variability (HRV) has repeatedly been correlated with improved performance under real life and simulator conditions. Using HRV as a correlate of workload, it is meaningful to assess the impact of work experience. To understand the impact of work experience on HRV metrics, we examined differences in HRV among experts and beginners during simulated endovascular neuroradiological procedures. Methods Six inexperienced radiologists (beginners) and five experts in neurological endovascular intervention each performed 10 diagnostic angiographies on a Vascular Interventional System Trainer (VIST) simulator (Mentice AB, SW). Beyond total time, fluoroscopy time, and amount of contrast medium used, heart rate variability and the NASA-task load index were gathered as correlates of workload. The t-Test for independent samples as well as Mann-Whitney-U tests were applied for group-wise comparison between beginners and experts. Multivariate regression was used to assess the influence of age and expert status. Results Ten participants completed all scenarios; one participant only completed the first five scenarios. Accordingly, 105 simulations were analyzed (beginners N = 60; experts N = 45, respectively). The heart rate variability of experts and beginners significantly differed in three time domain HRV metrics (decreased RMSSD, NN50, pNN50 in experts; all p < 0.05) as well as with respect to its distribution in the frequency spectrum (LF/HF ratio; p < 0.001, increased high frequency components in experts). Conclusions The HRV of beginners and expert neurointerventionalists significantly differed during simulated endovascular neuroradiological procedures. Experts presented decreased HRV, this could be a cardiovascular surrogate to the effort the subjects expend on their performance. It is in line with previous studies on vagal influences on the heart and cognitive-executive performance.
Effect of Obesity on Patient-Perceived Outcomes After First Metatarsophalangeal Joint Arthrodesis
Authors: Webb Alex R. , Manz Wesley J. , Fuqua Andrew , Coleman Michelle M. , Bariteau Jason T. , Kadakia Rishin J. 
Published: September 2022

Background: While first metatarsophalangeal joint (MTPJ) arthrodesis is a common and effective procedure, there is a paucity of studies examining obesity’s effect on outcomes of 1st MTPJ arthrodesis. This study’s purpose was to evaluate patient-reported outcomes following 1st MTPJ arthrodesis in obese versus non-obese patients. Methods: A retrospective cohort study of 94 patients undergoing first MTPJ fusion over the age of 18 with a diagnosis of hallux valgus or hallux rigidus was performed. Surgical and postoperative outcomes were examined preoperatively and at 6 and 12 months follow-up via Visual Analog Pain scale (VAS), and Short Form 36 (SF-36) surveys, and data were stratified into 2 patient groups: BMI < 30 (n = 62, mean age 63.9 ± 9.1 and ≥ 30 (n = 32, mean age 61.9 ± 8.4). Results: Average overall VAS and SF-36 physical component scores improved significantly at 6 months ( P < .001, .006) and 1 year postoperative visits ( P < .001, .007) with no differences in survey scores, outcomes, or complications between weight groups. Conclusion: Our study showed first MTPJ fusion improves short-term pain and physical quality-of-life in arthritic obese and non-obese patients without differences in nonunion, complications, or patient-reported measures. Level of Evidence: Level III, Prognostic, Case-Control Study
Diversity and Genetic Structure of Dicksonia navarrensis (Dicksoniaceae) Populations in the Mexican Sierra Madre Oriental
Authors: Reyes-Ortiz José Luis , Octavio-Aguilar Pablo , López-Mata Lauro , Sánchez-González Arturo 
Published: September 2022

Background and Research Aims Dicksonia navarrensis is a species of tree fern at risk of extinction, distributed in the montane cloud forest (MCF) of the Americas from the central region of Mexico to Ecuador. In Mexico, populations of this species grow in primary vegetation of the MCF, in a matrix with a high degree of fragmentation and under threat of disappearance. Methods In the present study, the diversity and genetic structure of seven populations of D. navarrensis that are distributed in the cloud forest of the Sierra Madre Oriental were evaluated, with both standard laboratory and statistical analysis techniques, using 11 microsatellites developed for the genus Dicksonia. Results A total of 33 alleles were found. Genetic diversity differed between populations, and some presented low heterozygosity. Using assignment tests, three genetic groups were identified, associated with the geographical distribution of the populations; those from the north maintain connectivity with each other but diverge highly from the populations in the south, probably due to processes of isolation by distance (local environment), genetic drift, and natural selection. Conclusion The northernmost population, which is more isolated from the rest, has a broader genetic reservoir, which can be useful for maintaining the genetic diversity of the species. In the other populations, with less genetic diversity, the introduction of individuals and/or the dispersion of spores is important, to maintain and increase the genetic variability that they still possess, but which could disappear in a short time if their habitat continues to deteriorate at a high degree. Implications for Conservation The results obtained provide basic information that can be used in management and conservation plans, because the populations with the greatest genetic diversity and the possible processes that are influencing the genetic structure of the species were identified.
Association of NAFLD with cardiovascular disease and all-cause mortality: a large-scale prospective cohort study based on UK Biobank
Authors: Ma Wen , Wu Wentao , Wen Weixing , Xu Fengshuo , Han Didi , Lyu Jun , Huang Yuli 
Published: September 2022

Objective: Nonalcoholic fatty liver disease (NAFLD) is considered as the hepatic manifestation of metabolic syndrome, sharing the similar cardiometabolic risk factors with cardiovascular disease (CVD). Whether NAFLD by itself is associated with increased cardiovascular events and death remain an issue to debate. This study aimed to further investigate the association between NAFLD and adverse CVD outcomes. Methods: Participants were followed up until the end of 2020 in current analysis. NAFLD is defined using fatty liver index (FLI). Cox proportional hazard model was used to analyze the association between NAFLD and all-cause mortality, major adverse cardiovascular events (MACEs), CVD mortality, fatal/nonfatal acute myocardial infarction (AMI), and fatal/nonfatal stroke. C-index was calculated to evaluate the model enhancement when adding NAFLD factor. Results: After screening the data of 502,492 participants in the original cohort, 215,245 eligible participants were included in this study for MACEs outcome. Compared with non-NAFLD participants, the multivariable adjusted hazard ratios of NAFLD group was 1.25 (1.14–1.36) for MACEs; 1.14 (1.08–1.20) for all-cause mortality; 1.61(1.42–1.82) for CVD mortality; 1.58(1.19–2.11) for AMI mortality; and 1.18 (0.85–1.64) for stroke mortality. When adding FLI, C-index of NAFLD model improved for all-cause mortality, MACEs, and CVD mortality compared with that in the traditional CVD risk factor model. Conclusion: NAFLD is an independent risk factor for all-cause mortality and adverse CVD outcomes. Based on the traditional CVD risk factor model, additionally screening NAFLD could improve the prediction efficiency for adverse CVD outcomes.
Clinical outcome analysis of patients with autism spectrum disorder: analysis from the UK Medical Cannabis Registry
Authors: Erridge Simon , Kerr-Gaffney Jess , Holvey Carl , Coomber Ross , Barros Daniela A. Riano , Bhoskar Urmila , Mwimba Gracia , Praveen Kavita , Symeon Chris , Sachdeva-Mohan Simmi , Sodergren Mikael H. , Rucker James J. 
Published: September 2022

Introduction: Cannabis-based medicinal products (CBMPs) have been identified as a promising novel therapeutic for symptoms and comorbidities related to autism spectrum disorder (ASD). However, there is a paucity of clinical evidence of their efficacy and safety. Objective: This case series aims to assess changes to health-related quality of life and the incidence of adverse events in patients treated with CBMPs for associated symptoms of ASD enrolled on the UK Medical Cannabis Registry (UKMCR). Methods: Patients treated with CBMPs for ASD-related symptoms for a minimum of 1 month were identified from the UKMCR. Primary outcomes were changes in validated patient-reported outcome measures [Generalised Anxiety Disorder-7 (GAD-7), Single-Item Sleep Quality Scale (SQS), 5-level version of the EQ-5D (EQ-5D-5L) index values] at 1, 3 and 6 months compared with baseline. Adverse events were recorded and analysed. Statistical significance was determined by p < 0.050. Results: Seventy-four patients with ASD were included in the analysis. The mean age of participants was 32.7 (±11.6) years. There were significant improvements in general health-related quality of life and sleep as assessed by the EQ-5D-5L, SQS and GAD-7 at 1 and 3 months, with sustained changes in EQ-5D-5L and SQS at 6 months ( p < 0.010). There were 180 (243.2%) adverse events reported by 14 (18.9%) participants. If present, adverse events were commonly mild ( n = 58; 78.4%) or moderate ( n = 81; 109.5%), rather than severe ( n = 41; 55.4%). Conclusion: This study demonstrated an associated improvement in general health-related quality of life, and anxiety- and sleep-specific symptoms following initiation of treatment with CBMPs in patients with ASD. These findings, while promising, are limited by the confines of the study which lacks a control arm and is subject to attrition bias. Therefore, further evaluation is required with randomised controlled trials.
How Relationship Satisfaction and Negative Communication Trajectories Change in Emerging Adults’ Dating Relationships: A Group-Based Dual Trajectory Analysis
Authors: Jolin Stéphanie , Lafontaine Marie-France , Lussier Yvan , Brassard Audrey 
Published: September 2022

Early romantic relationships are salient to the development of healthy future relationships. Yet, little is known about the evolution of romantic relationships of emerging adults since most of the research has been conducted on married or well-established couples. The current study aims to examine how relationship satisfaction and negative communication evolve and are interrelated during emerging adulthood. Using age as a time metric, we conducted group-based dual trajectory modeling analyses on 1566 unmarried Canadian individuals (from 17 to 24 years old) in a relationship, who could either stay with the same partner or change partner over time. A four-group model for relationship satisfaction and a four-group model for negative communication were found. Dual analyses highlighted the high concordance between specific trajectories of both constructs. These findings demonstrate that relationship satisfaction and negative communication do not evolve in the same ways for everyone and provide useful insights to existing clinical interventions.
Diabetes Care Network: A Novel Model to Disseminate Team-Based Diabetes Specialty Care in a Rural Population
Authors: Zupa Margaret F. , Beattie Janice , Boudreaux-Kelly Monique , Larson Meg , Lumley Brandi , Lutz-McCain Stacey , Summerville Ashley , Bandi Archana 
Published: September 2022

Purpose: The purpose of the study was to examine the impact of a novel approach to provide diabetes specialty team care to rural patients with type 2 diabetes (T2DM) on clinical outcomes and processes of care. Methods: Diabetes Care Network (DCN) provides Veterans with T2DM and elevated A1C an initial 6-week period of remote self-management education and support and medication management by a centrally located team of diabetes specialists. Participants are then comanaged by remote liaisons embedded in rural primary care facilities for the remainder of the 12-month intervention. In this pre-post intervention study, 87 Veterans enrolled in DCN from 2 different clinical sites had baseline and 12-month postenrollment A1C, systolic blood pressure, weight, and LDL cholesterol levels collected and compared using paired t tests. Results: Participants were mostly male and White with elevated baseline A1C. Participants from both sites had significant improvement in A1C over the 12-month intervention period compared to an increase in the 12 months prior to enrollment. There were also significant improvements in LDL and systolic blood pressure at 1 site, with no significant change in weight at either site. Conclusions: DCN participants had significant improvement in A1C after not meeting similar goals previously in a robust primary care setting. A technology-enabled collaborative partnership between centrally located diabetes care teams and local liaisons is a feasible approach to enhance access to diabetes specialty care for rural populations.
Arthroscopic Visualization of Femoral Cortical Button Deployment During Anterior Cruciate Ligament Reconstruction
Authors: Apsingi Sunil , Mohammed Murtuza Ahmed , Parameswaran Apurve , Dannana Chandra Sekhar , Eachempati Krishna Kiran 
Published: September 2022

Background: Up to 25% of femoral cortical suspensory fixation devices are reported to be deployed inappropriately during anterior cruciate ligament (ACL) reconstruction. Most techniques for visualizing suspensory button deployment reported in the literature are for adjustable loop buttons and outside-in femoral tunnel technique. Intraoperative radiographs are inconvenient and involve exposure to radiation. No “gold standard” technique for visualization of femoral cortical button deployment has been described yet. Indications: This technique can be employed for all patients requiring ACL reconstruction surgery. Technique Description: The femoral tunnel is prepared from the anteromedial portal. With the knee in flexion, a beath pin loaded with a suture loop is passed via the anteromedial portal through the femoral tunnel; the eyelet of the pin with the suture loop is retained in the femoral tunnel. The knee is extended without fear of bending the beath pin. The arthroscope is shifted into the lateral gutter. An outside-in lateral parapatellar portal is made at the level of the center of the patella, 1 cm lateral to its lateral edge. The joint capsule and soft tissues in the lateral gutter are resected using a shaver. The beath pin is identified without fear of lacerating the suture loop. The exit point of the pin depends on the knee flexion at the time of femoral tunnel preparation, and more flexion results in more anterior pin exit and vice versa. The rest of the surgery is performed as planned. The definitive sutures of the desired femoral cortical suspensory device are passed from the tibial tunnel into the femoral tunnel. The arthroscope is then positioned in the lateral gutter and the cortical button is deployed appropriately under vision, onto the lateral femoral cortex. If required, the cortical button can be manipulated to seat it appropriately, using an instrument from the lateral parapatellar portal. The remainder of the surgery is performed as per the surgeon’s preference. Results: We routinely perform this step during ACL reconstruction. It adds 2 to 4 minutes to the surgical time. We have not encountered any complications of this procedure. Discussion/Conclusion: This maneuver is effective in facilitating appropriate deployment of femoral cortical suspensory devices under vision.