bluuebunny/crossref_metadata_2025_split huggingface dataset:
A longitudinal 18F-FDG PET/MRI study in asymptomatic stage of genetic Creutzfeldt–Jakob disease linked to G114V mutation
Authors: Chu Min , Chen Zhongyun , Nie Binbin , Liu Li , Xie Kexin , Cui Yue , Chen Kewei , Rosa-Neto Pedro , Wu Liyong 
Published: July 2022

Abstract
Background
Pathogenic prion protein may start to deposit in some brain regions and cause functional alterations in the asymptomatic stage in Creutzfeldt–Jakob disease. The study aims to determine the trajectory of the brain metabolic changes for prion protein diseases at the preclinical stage.

Methods
At baseline, we enrolled five asymptomatic PRNP G114V mutation carriers, six affected genetic PRNP E200K CJD patients and 23 normal controls. All participants completed clinical, diffusion-weighted imaging (DWI) and 18F fluorodeoxyglucose-positron emission tomography (18F-FDG-PET) examinations. Longitudinal follow-up was completed in five asymptomatic mutation carriers. We set three-time points to identify the changing trajectory in the asymptomatic carriers group including baseline, 2-year and 4-year follow-up.

Results
At baseline, DWI signals, the cerebral glucose standardized uptake value rate ratio (SUVR) and clinical status in 5 asymptomatic cases were normal. At the follow-up period, mild hypometabolism on PET images was found in asymptomatic carriers without any DWI abnormal signal. Further group quantitatively analysis showed hypometabolic brain regions in the asymptomatic genetic CJD group were in the insula, frontal, parietal, and temporal lobes in 4-year follow-up. The SUVR changing trajectories of all asymptomatic cases were within the range between the normal controls and affected patients. Notably, the SUVR of one asymptomatic individual whose baseline age was older showed a rapid decline at the last follow-up.

Conclusions
Our study illustrates that the neurodegenerative process associated with genetic CJD may initiate before the clinical presentation of the disease.
The timing of tether breakage influences clinical results after VBT
Authors: Baroncini A. , Migliorini F. , Eschweiler J. , Hildebrand F. , Trobisch P. 
Published: July 2022

Abstract
Introduction
Tether breakage is a frequent mechanical complications after vertebral body tethering (VBT), but not all patients with a breakage show loss of correction. The reason of this clinical finding has not yet been clarified. We hypothesized that the integrity of the tether is relevant only in the early stages after VBT, when it drives growth modulation and tissue remodelling. After these mechanisms have taken place, the tether loses its function and a breakage will not alter the new shape of the spine. Thus, tether breakage would have a greater clinical relevance when occurring shortly after surgery.

Methods
All consecutive patients who underwent VBT and had a min. 2-year follow-up were included. The difference in curve magnitude between the 1st standing x-ray and the last follow-up was calculated (ΔCobb). For each curve, the presence and timing of tether breakage were recorded. The curves were grouped according to if and when the breakage was observed (no breakage, breakage at 0–6 months, 6–12 months, > 12 months). The ΔCobb was compared among these groups with the analysis of variance (ANOVA).

Results
Data from 152 curves were available: 68 with no breakage, 12 with a breakage at 0–6 months, 37 at 6–12 months and 35 > 12 months. The ANOVA found significant difference in the ΔCobb among the groups (Sum of square 2553.59; degree of freedom 3; mean of square 851.1; Fisher test 13.8; P < 0.0001). Patients with no breakage or breakage at > 12 months had similar ΔCobb (mean 4.8° and 7.8°, respectively, P = 0.3), smaller than the 0–6 or 6–12 groups (15.8° and 13.8°, respectively).

Conclusion
Tether breakage leads to a consistent loss of correction when occurring within the first 12 months, while it has limited clinical relevance when occurring later on.
SDCF: semi-automatically structured dataset of citation functions
Authors: Basuki Setio , Tsuchiya Masatoshi 
Published: July 2022

AbstractThere is increasing research interest in the automatic detection of citation functions, which is why authors of academic papers cite previous works. A machine learning approach for such a task requires a large dataset consisting of varied labels of citation functions. However, existing datasets contain a few instances and a limited number of labels. Furthermore, most labels have been built using narrow research fields. Addressing these issues, this paper proposes a semiautomatic approach to develop a large dataset of citation functions based on two types of datasets. The first type contains 5668 manually labeled instances to develop a new labeling scheme of citation functions, and the second type is the final dataset that is built automatically. Our labeling scheme covers papers from various areas of computer science, resulting in five coarse labels and 21 fine-grained labels. To validate the scheme, two annotators were employed for annotation experiments on 421 instances that produced Cohen’s Kappa values of 0.85 for coarse labels and 0.71 for fine-grained labels. Following this, we performed two classification stages, i.e., filtering, and fine-grained to build models using the first dataset. The classification followed several scenarios, including active learning (AL) in a low-resource setting. Our experiments show that Bidirectional Encoder Representations from Transformers (BERT)-based AL achieved 90.29% accuracy, which outperformed other methods in the filtering stage. In the fine-grained stage, the SciBERT-based AL strategy achieved a competitive 81.15% accuracy, which was slightly lower than the non-AL strategy. These results show that the AL is promising since it requires less than half of the dataset. Considering the number of labels, this paper released the largest dataset consisting of 1,840,815 instances.
Supply chain finance for ameliorating and deteriorating products: a systematic literature review
Authors: Marchi Beatrice , Zavanella Lucio E. , Zanoni Simone 
Published: July 2022

AbstractAmeliorating and deteriorating products, or, more generally, items that change value over time, present a high sensitiveness to the surrounding environment (e.g., temperature, humidity, and light intensity). For this reason, they should be properly stored along the supply chain to guarantee the desired quality to the consumers. Specifically, ameliorating items face an increase in value if there are stored for longer periods, which can lead to higher selling price. At the same time, the costumers’ demand is sensitive to the price (i.e., the higher the selling price the lower the final demand), sensitiveness that is related to the quality of the products (i.e., lower sensitiveness for high-quality products). On the contrary, deteriorating items lose quality and value over time which result in revenue losses due to lost sales or reduced selling price. Since these products need to be properly stored (i.e., usually in temperature- and humidity-controlled warehouses) the holding costs, which comprise also the energy costs, may be particularly relevant impacting on the economic, environmental, and social sustainability of the supply chain. Furthermore, due to the recent economic crisis, companies (especially, small and medium enterprises) face payment difficulties of customers and high volatility of resources prices. This increases the risk of insolvency and on the other hand the financing needs. In this context, supply chain finance emerged as a mean for efficiency by coordinating the financial flow and providing a set of financial schemes aiming at optimizing accounts payable and receivable along the supply chain. The aim of the present study is thus to investigate through a systematic literature review the two main themes presented (i.e., inventory management models for products that change value over time, and financial techniques and strategies to support companies in inventory management) to understand if any financial technique has been studied for supporting the management of this class of products and to verify the existing literature gap.
Effects of culture methods and plant growth regulators on in vitro propagation of Brassavola nodosa (L.) Lindl. hybrid
Authors: Xu JianJian , Beleski David G. , Vendrame Wagner A. 
Published: July 2022

AbstractBrassavola nodosa (L.) Lindl. is an epiphytic orchid with great potential for the ornamental plant industry. The lack of information on propagation and production techniques limits the development of large-scale commercial production. Furthermore, this species is experiencing a reduction in population due to habitat destruction, the impact of climate change, and over-collection from native habitats. This study aimed at developing an efficient protocol for micropropagation of B. nodosa, which could be valuable towards the large-scale commercial production as well as for conservation of this species. Six different concentrations of plant growth regulators (BA or IBA, with or without adenine sulfate) were evaluated in modified Murashige and Skoog (MS) medium for shoot multiplication. In addition, two concentrations of either NAA or IBA were evaluated for rooting. Explants were cultured under three different culture media conditions: semi-solid medium, liquid medium (partial immersion), and liquid medium (complete immersion). Results indicate that B. nodosa could be successfully micropropagated in liquid culture with partial immersion. The modified MS medium supplemented with 2.0 mg L−1 BA and 30.0 mg L−1 adenine sulfate resulted in higher multiplication rates. Rooting was obtained using either 0.5 mg L−1 NAA or 1.0 mg L−1 IBA with no significant differences between both rooting treatments. Plantlets achieved 100% ex vitro survival after 30-d acclimatization.
Sir Richard Morison: An Early Reader of Cassius Dio in Tudor England?
Authors: Mallan C. T. 
Published: July 2022

AbstractScholars have suggested that Cassius Dio’s Roman History was among the Greek sources used by the 16th century polemicist Sir Richard Morison in two of his treatises from the 1530s. This short article shows that this is not the case. Rather, Morison can be seen to be borrowing from Seneca’s De Clementia and Politian’s Latin translation of Herodian’s History of the Empire after Marcus Aurelius. This conclusion may cast some further light on the provenance of the booklist contained in British Library Add. MS 40,676 (ff. 110r-116r), and its attribution to Morison.
Conceptualisations of health in orthorexia nervosa: a mixed-methods study
Authors: Greville-harris Maddy , Talbot Catherine V. , Moseley Rachel L. , Vuillier Laura 
Published: July 2022

Abstract
Purpose
Limited research has explored conceptualisations of health and healthy eating in orthorexia nervosa (ON). This mixed-methods study aimed to investigate how ‘health’ and ‘healthy eating’ are conceptualised by individuals at risk for ON. This study examined the potential relationships between health anxiety, beliefs about health controllability and orthorexic symptomatology in our broader sample.

Methods
A total of 362 participants took a survey on health anxiety (measured with the HAQ), beliefs about the controllability of one’s own health (IMHLC) and ON symptomatology (E-DOS and EHQ). Participants ‘at risk’ for ON (n = 141), also completed an online qualitative survey about conceptualisations of health and healthy eating. Qualitative data were analysed using thematic analysis (part A). The PROCESS macro for SPSS was used for the quantitative analysis (part B).

Results
Conceptualisations of health and healthy eating were complex. Four themes were generated from our qualitative data: ‘health is more than thin ideals’, ‘healthy food equals healthy mind’, ‘a body that works for you’ and ‘taking control of your body’. Our quantitative analysis revealed that health anxiety and beliefs in health controllability independently predicted ON symptomatology.

Conclusion
A richer understanding of what health means in the context of ON is important, given the centrality of this concept to the proposed classification of this disordered eating style. Our findings highlight that both health anxiety and health controllability are important targets for future investigation, given their potential relevance to the aetiology and treatment of ON.

Level of evidence
Level V, based on a descriptive study.
Interacting particle systems and Jacobi style identities
Authors: Balázs Márton , Fretwell Dan , Jay Jessica 
Published: July 2022

AbstractWe consider the family of nearest neighbour interacting particle systems on $$\mathbb {Z}$$
Z
allowing 0, 1 or 2 particles at a site. We parametrise a wide subfamily of processes exhibiting product blocking measure and show how this family can be “stood up” in the sense of Balázs and Bowen (Ann Inst H Poincaré Probab Stat 54(1):514–528, 2018). By comparing measures, we prove new three variable Jacobi style identities, related to counting certain generalised Frobenius partitions with a 2-repetition condition. By specialising to specific processes, we produce two variable identities that are shown to relate to Jacobi triple product and various other identities of combinatorial significance. The family of k-exclusion processes for arbitrary k are also considered and are shown to give similar Jacobi style identities relating to counting generalised Frobenius partitions with a k-repetition condition.
An Improved AdaBoost for Prosecutorial Case-Workload Estimation via Case Grouping
Authors: Min Xin , Li Wei , Yang Jinzhao , Xie Weidong , Zhao Dazhe 
Published: July 2022

AbstractCase-workload estimation has always been a complex process and plays a vital role in prosecutorial work. Despite the increasing development of rule-based techniques, artificial intelligence and machine learning have rarely been used to study case-workload estimation problems, leaving many cases processed without quantitative estimation. This paper aims to develop a new case-work estimation method that combines artificial intelligence methods with practical needs and apply it to the case assignment system of the prosecutor’s office. We propose a feature learning model, the improved AdaBoost model, to capture the features of cases for case grouping to estimate case workload. We first learn the case textual data based on the judicial proper noun dictionary, extract the case labels from the case information with the AdaBoost learner, and group and encode each case by fuzzy matching. Then, the extracted vital information estimates case workload based on the length of case processing time and suspects number, respectively. We conducted extensive experiments to compare the proposed method with eight baseline methods, including the traditional AdaBoost classifier, to evaluate the performance of the proposed model on a real prosecution case dataset. The experimental results demonstrate the superiority of our proposed workload estimation model.
RADIOCARBON CHRONOLOGY OF DOLMENS IN THE IBERIAN SOUTHWEST: ARCHITECTURAL SEQUENCE AND TEMPORALITY IN THE EL POZUELO MEGALITHIC COMPLEX (HUELVA, SPAIN)
Authors: Linares-Catela José Antonio 
Published: July 2022

ABSTRACTThis paper establishes the chronology of the El Pozuelo megalithic complex and discusses it in the context of other dolmens that have been dated in the southwest of the Iberian Peninsula. The working methodology combines the study of the stratigraphy and architectural sequence with the Bayesian modeling of the 27 AMS 14C dates obtained for charcoal samples from the four monuments in the Los Llanetes cluster. The most significant chronological results (at 68% probability) are (a) the antiquity and long duration of the megalithic sites, in which several monumental structures succeeded one another ca. 3970–1980 cal BC; (b) the existences of different temporalities in the Late-Final Neolithic dolmens: simple chambers (3970–3760 cal BC), elongated chambers (3790–3620 cal BC) and multiple chambers (3660–3260 cal BC; (c) the continuity of activity during the Copper Age (2980–2580 and 2530–2180 cal BC); and (d) the permanence of megalithism in the Early Bronze Age, through the presence of terraced enclosures with circular platforms ca. 2230–1940 cal BC. This diachronic sequence and the contextualized analysis of the 152 available radiocarbon dates (27 new, 125 published) supports the establishment of the temporal dynamics of megalithism in the Iberian southwest, introducing key aspects on the emergence, span, and rebuilding of the different dolmens (passage graves, simple chambers, elongated chambers, and multiple chambers) and establishing the phases of activity and reuse of the different architectural types.
Maturity Clienteles and Corporate Bond Maturities
Authors: Butler Alexander W. , Gao Xiang , Uzmanoglu Cihan 
Published: July 2022

AbstractThe average maturity of newly issued corporate bonds has declined substantially over the past 40 years, and the traditional determinants of debt maturity fail to explain this decline fully. We show that the changing composition of investors in the corporate bond market influences bond maturities. The results of a Granger causality test, an instrumental variable approach, and a natural experiment suggest that a decline in the insurance companies’ – which prefer long-term bonds – ownership share in the corporate bond market explains a significant part of the unexplained maturity decline. These findings illustrate how investor preferences can have real effects on corporations.
Kinematics of a nine-legged in-parallel manipulator with configurable platform
Authors: Gallardo-Alvarado Jaime , Garcia-Murillo Mario A. , Rodriguez-Castro Ramon 
Published: July 2022

AbstractConfigurable platforms bring a research field to expand the attributes of parallel manipulators. This work is devoted to investigate the kinematics of a nine-degrees-of-freedom parallel manipulator whose active kinematic pairs are located near to the fixed platform, and it is equipped with a 6-R configurable platform. The mobility of the proposed 9-UPUR{6R} configurable parallel manipulator is such that it is possible to manipulate the kinematics of a grasping triangle associated to the configurable platform. The theory of screws is systematically applied to solve the direct and inverse infinitesimal kinematics of the manipulator. As an intermediate step, the displacement analysis is approached by means of algebraic geometry. The contribution is complemented with numerical examples to illustrate the versatility of the method of kinematic analysis.
Comparing patient acceptability of MR-guided radiotherapy to conventional CBCT on two Elekta systems: a questionnaire-based survey
Authors: Whiteside Lee , Nelder Claire , Pitt Eleanor , Hodgson Clare , Choudhury Ananya , Eccles Cynthia L. 
Published: July 2022

AbstractBackground and Purpose:The magnetic resonance linear accelerator system (MR Linac) is a novel piece of radiotherapy (RT) equipment allowing the routine application of daily MR-guided treatment adaptation. The hardware design required for such technical capabilities and the increased complexity of the treatment workflow entails a notable departure from cone beam computed tomography (CBCT)-based RT. Patient tolerability of treatment is paramount to RT practice where high compliance is required. Presented is a comparative analysis of how such modality specific characteristics may ultimately impact the patient experience of treatment.Materials and Methods:Forty patients undergoing RT for prostate cancer (PCa) on either the MR Linac (n= 20) or a CBCT-based linac (n= 20) were provided with a validated patient reported outcomes measures (PROM’s) questionnaire at fraction 1 and fraction 20. The 18-item questionnaire provided patient responses recorded using a 4-point Likert scale, 0 denoting a response of ‘Not at all’, 1 ‘Slightly’, 2 ‘Moderately’ and 3 signifying ‘Very’. The analysis provided insight into both comparisons between modalities at singular time points (fractions 1 and 20), as well as a temporal analysis within a single modality, denoting changing patient experience.Results:Patients generally found the MR Linac treatment couch more comfortable, however, found the increase in treatment duration harder to tolerate. Responses for all items remained stable between first and last fraction across both cohorts, indicating minimal temporal variation within a single modality. None of the responses were statistically significant at the 0·01 level.Conclusion:Whether radiotherapy for PCa is delivered on a CBCT linac or the MR Linac, there is little difference in patient experience with minimal experiential variation within a single modality.
Does Sea Spray Aerosol Contribute Significantly to Aerosol Trace Element Loading? A Case Study From the U.S. GEOTRACES Pacific Meridional Transect (GP15)
Authors: Marsay Chris M. , Landing William M. , Umstead Devon , Till Claire P. , Freiberger Robert , Fitzsimmons Jessica N. , Lanning Nathan T. , Shiller Alan M. , Hatta Mariko , Chmiel Rebecca , Saito Mak , Buck Clifton S. 
Published: July 2022

AbstractAtmospheric deposition represents a major input for micronutrient trace elements (TEs) to the surface ocean and is often quantified indirectly through measurements of aerosol TE concentrations. Sea spray aerosol (SSA) dominates aerosol mass concentration over much of the global ocean, but few studies have assessed its contribution to aerosol TE loading, which could result in overestimates of “new” TE inputs. Low‐mineral aerosol concentrations measured during the U.S. GEOTRACES Pacific Meridional Transect (GP15; 152°W, 56°N to 20°S), along with concurrent towfish sampling of surface seawater, provided an opportunity to investigate this aspect of TE biogeochemical cycling. Central Pacific Ocean surface seawater Al, V, Mn, Fe, Co, Ni, Cu, Zn, and Pb concentrations were combined with aerosol Na data to calculate a “recycled” SSA contribution to aerosol TE loading. Only vanadium was calculated to have a SSA contribution averaging >1% along the transect (mean of 1.5%). We derive scaling factors from previous studies on TE enrichments in the sea surface microlayer and in freshly produced SSA to assess the broader potential for SSA contributions to aerosol TE loading. Maximum applied scaling factors suggest that SSA could contribute significantly to the aerosol loading of some elements (notably V, Cu, and Pb), while for others (e.g., Fe and Al), SSA contributions largely remained <1%. Our study highlights that a lack of focused measurements of TEs in SSA limits our ability to quantify this component of marine aerosol loading and the associated potential for overestimating new TE inputs from atmospheric deposition.
Salt Intrusion as a Function of Estuary Length in Periodically Weakly Stratified Estuaries
Authors: Wei Xiaoyan , Williams Megan E. , Brown Jennifer M. , Thorne Peter D. , Amoudry Laurent O. 
Published: July 2022

AbstractEstuarine salt intrusion greatly threatens freshwater supply in surrounding lands. Physical barriers, which reduce the estuary length (L), are widely constructed to control salt intrusion. Yet, the role of L in salt intrusion remains unknown. Using a process‐based, idealized, semi‐analytical three‐dimensional model, we systematically investigate for the first time this unknown for tide‐dominated, periodically weakly stratified estuaries. Results show decreasing L significantly reduces salinities for short estuaries (L < Lw/4, with Lw the dominant tidal wavelength), but not for long estuaries. Tidal pumping remains a key salt importer in most estuaries, regardless of L. However, substantial decreases in L relative to Lw/4 can change the dominant landward salt importer from tidal pumping to horizontal diffusion. The latter, together with gravitational circulation, weakens responses of salt intrusion to changes in tidal and river forcing in short estuaries. This study highlights the importance of considering L to understanding and mitigating salt intrusion.