bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevention of lymphoedema after axillary clearance by external compression sleeves PLACE randomised trial results. Effects of high BMI
Authors: Bundred Nigel J. , Barrett Emma , Todd Chriss , Morris Julie , Watterson Donna , Purushotham Arnie , Riches Katie , Evans Abigail , Skene Anthony , Keeley Vaughan ,   the Investigators of BEA/PLACE studies
Published: December 2022

AbstractAround 25% of women undergoing Axillary Clearance (ANC) develop lymphedema (LE). Intervention with a compression garment is recommended to prevent LE but no randomised evidence exists to support this strategy.MethodsA randomised trial tested standard management versus application of graduated compression garments (20‐24 mmHg) to affected arm, for 1 year. Women with node positive breast cancer (n = 1300) undergoing ANC consented to arm volume measurements and those developing a 4–9% relative arm volume increase (RAVI) (subclinical LE) within 9 months post‐surgery were randomised. Primary outcome was proportion of patients developing LE (RAVI > 10%) by 24‐months in each group. Secondary endpoints included Quality of life in each group.ResultsIn total 143 patients were randomised (74 no sleeve: 69 compression sleeve) between October 2010 and November 2015. The lymphoedema rate at 24 months in the ‘no sleeve’ group was at 41%, similar to the ‘sleeve’ group (30%: p = 0.32). Thirtytwo patients randomised to the ‘no sleeve’ group had a sleeve applied within 24 months. Body Mass Index (BMI) at randomisation predicted LE at any time point HR 1.04 (CI 1.01–1.08; p = 0.01). Patients with obesity (BMI > 30) had higher rates of LE in both groups (46%) compared to those with BMI < 30 (24%). No difference between patients was found in either group in changes in QoL. Compression sleeves applied after development of LE improved QoL scores (FACT‐B p = 0.007:TOI p = 0.042).ConclusionEarly intervention with External Compression garments does not prevent clinical LE, particularly in women with a high BMI > 30. The use of prophylactic garments in subclinical LE (RAVI < 9%) is unwarranted.
Bilateral primary synovial chondromatosis in the knee joint
Authors: Shafie Mahan , Babaei Aghdam Zahra , Shirzad Moghaddam Zeinab , Ayati Firoozabadi Mohammad , Emami Razavi Seyedeh Zahra , Hosseini Maryam , Azadvari Mohaddeseh 
Published: December 2022

AbstractPrimary synovial chondromatosis is a disorder characterized by the metaplasia of the synovial membrane and the formation of loose bodies floating in the joint. We described a 30‐year‐old woman without any past medical history complaining of bilateral progressive knee pain who was later discovered to have bilateral synovial chondromatosis.
Acute myocardial infarction followed by radiofrequency therapy for gastroesophageal reflux disease in a man: A case report
Authors: Xu Zhihong , He Suyu , Xiong Xin , Zhang Xiumei , Feng Caiju , Tang Shilin , Liu Yijun , Wu Lili 
Published: December 2022

AbstractCoronary artery disease (CAD) is a common comorbidity of gastroesophageal reflux disease. Since the distal esophagus and heart share a common afferent vagal supply, the delivery of radiofrequency in the distal esophagus can stimulate the coronary artery and induce acute myocardial infarction in a patient with CAD.
Experiments on the Dynamic Behavior of the Chemical Looping Combustion Process
Authors: Lindmüller Lennard , Haus Johannes , Heinrich Stefan 
Published: December 2022

AbstractThe dynamic operation of thermal power plants becomes more and more important due to more diverse and volatile power sources. Load changes of biomass, bituminous coal and methane were conducted during six experimental runs in a chemical looping combustion pilot plant which combines power generation and CO2 capture. The resulting step responses of the hydrodynamics and gas concentrations were compared to each other to understand the transient behavior of the interconnected fluidized bed system. The influence of the fuel rate and solid circulation on the response time and intensity was assessed.
Single‐dose Pharmacokinetics of Eluxadoline in Healthy Participants With Normal Renal Function and Participants With Renal Impairment
Authors: Boinpally Ramesh , Weissman Darren 
Published: December 2022

AbstractEluxadoline is approved for the treatment of diarrhea‐predominant irritable bowel syndrome in the United States. The impact of renal impairment on the pharmacokinetic (PK) parameters of eluxadoline is currently unknown. This phase 1, open‐label, parallel‐group study evaluated the PK and safety profile of eluxadoline in 8 participants with renal impairment and 8 matched healthy controls. Of the participants with renal impairment, 2 had severe renal impairment (estimated glomerular filtration rate [eGFR] <30 mL/min/1.73 m2) and 6 had end‐stage renal disease while not yet on dialysis (eGFR <15 mL/min/1.73 m2). The primary objective was to assess plasma and urine PKs, and plasma protein binding of eluxadoline. In participants with renal impairment, mean plasma concentrations of eluxadoline were consistently higher compared with matched healthy controls: 1.4‐fold higher for mean maximum plasma concentration (Cmax) and 2.2‐fold higher for mean area under the plasma concentration‐time curve from time 0 to time t. The median time to Cmax was 2.5 hours in both groups. Although eluxadoline is a locally acting drug with low oral bioavailability, because of the increased systemic exposure in participants with renal impairment as a cautionary measure the lower approved dose of 75 mg twice daily is recommended for individuals with severe renal impairment and end‐stage renal disease while not yet on dialysis. Eluxadoline 100 mg single dose was well tolerated in participants with renal impairment and matched healthy controls.
An Automated Computer‐Vision “Bubble‐Counting” Technique to Characterise CO2 Dissolution into an Acetonitrile Flow Stream in a Teflon AF‐2400 Tube‐in‐Tube Flow Device
Authors: O'Brien Matthew , Moraru Ruxandra 
Published: December 2022

AbstractInvited for this month′s cover is the group of Matt O'Brien at Keele University. The cover picture shows a depiction of ‘computer vision’ in the context of CO2 dissolution into tube‐in‐tube membrane devices in continuous flow. The original manuscript is part of the Special Collection on “Automation in Chemistry and Beyond” and more information can be found in the Research Article by Matthew O'Brien and Ruxandra Moraru.
Augmenting the unified protocol with transcranial direct current stimulation: Effects on emotion regulation and executive dysfunction
Authors: Nasiri Farzad , Ellard Kristen K. , Mashhadi Ali , Bigdeli Imanollah , Ghanaei‐Chamanabad Ali 
Published: December 2022

AbstractThe aim of the current study was to compare the unified protocol for transdiagnostic treatment of emotional disorders (UP) with and without transcranial direct current stimulation (tDCS) for the treatment of emotion regulation and executive control dysfunction in individuals diagnosed with generalized anxiety disorder (GAD) and comorbid major depressive disorder (MDD). A total of 43 individuals with GAD and co‐morbid MDD were randomly assigned to three groups including UP with tDCS (UP+tDCS; n = 15), UP alone (UP; n = 13) or wait‐list control (n = 15). Difficulties in emotion regulation, reappraisal, suppression, inhibition and working memory were assessed at baseline, post‐treatment and 3‐month follow‐up. Treatment with both UP+tDCS and UP alone resulted in significant improvements in difficulties in emotion regulation, cognitive reappraisal, and working memory, and significant reductions in suppression and inhibition relative to wait‐list controls at post‐treatment and 3‐month follow‐up. Relative to UP alone, UP+tDCS showed significantly greater improvements in difficulties in emotion regulation, cognitive reappraisal, inhibition, and working memory at post‐treatment and 3‐month follow‐up. These results suggest combination of UP treatment with tDCS may be an efficacious intervention to improve emotion regulation and executive function in GAD with co‐morbid MDD. Trial registration reference is IRCT20140929019334N1 (see https://irct.ir/trial/27988).
An examination of the heterogeneity of the relationships between posttraumatic stress disorder, self‐compassion and gratitude
Authors: Brier Zoe M. F. , Burt Keith B. , Legrand Alison C. , Price Matthew 
Published: December 2022

AbstractPrevious research has found both self‐compassion and gratitude to be protective against overall posttraumatic stress disorder (PTSD) symptom severity. PTSD is a highly heterogeneous disorder; however, it is unclear if these protective constructs are differentially associated with each cluster of PTSD. The present study examined differences in the association of self‐compassion and gratitude with the four clusters of PTSD as indicated by the DSM‐5. Participants were 1424 trauma‐exposed individuals recruited via Amazon's Mechanical Turk. The mean age of participants was 31.49 (SD = 11.25) years old, and 55.3% of the sample identified as female. A structural equation model (SEM) approach was used to examine relationships between factors of gratitude, self‐compassion and the four PTSD symptom clusters. A two‐factor model of self‐compassion best fits the data. Both the self‐compassion and gratitude factors were significantly associated with all symptom clusters of PTSD. Wald chi‐square tests indicated self‐compassion and gratitude to have the strongest association with negative alterations in cognitions and mood (NACM) PTSD symptoms. These findings may have important implications for treatment targets to reduce specific symptoms of PTSD, particularly in PTSD symptoms related to negative affect.
RNA N6‐methyladenosine connects YTHDF3 and LOXL3 to promote melanoma metastasis
Authors: Nirmal Mamta B , Vo Tommy V. 
Published: December 2022

AbstractN6‐methyladenosine (m6A) modifications of RNAs are associated with diverse biological processes in normal and cancer cells. In melanoma cancers, mutations in genes that function in the writing or erasure of RNA m6A have been shown to affect cancer progression and metastasis. More recently, Shi et al. find that a protein which binds to the m6A modification, called YTHDF3, is widely overexpressed in melanoma cell lines and patient samples. Through multi‐omics and targeted RNA analyses, they uncover a novel YTHDF3‐LOXL3 axis which contribute to in vitro melanoma invasion and in vivo metastasis. Here, we discuss these findings and highlight several possible new and exciting research directions stemming from this research.
Does environmental adaptation or dispersal history explain the geographical distribution of Ixodes ricinus and Ixodes persulcatus ticks in Finland?
Authors: Kulha Niko , Ruokolainen Kalle , Vesterinen Eero J. , Lamppu Maija , Klemola Tero , Sormunen Jani J. 
Published: December 2022

AbstractIn Finland, the distribution area of the taiga tick, Ixodes persulcatus (Schulze, 1930), is nested within a broader area of distribution of a congeneric species, the sheep tick, Ixodes ricinus (Linnaeus, 1758) (Acari: Ixodidae). We assess whether distinct environmental adaptations or dispersal history provides a more parsimonious explanation for the differences in the distributions of the two common and medically important ixodids in Finland. We used an innovative spatially constrained randomization procedure to analyze whether crowdsourced occurrence data points of the two tick species had statistically different associations with any of the 28 environmental variables. Using points of presence in a region of species co‐occurrence, we built Maxent models to examine whether environmental factors or dispersal history could explain the absence of I. persulcatus in a part of the range of I. ricinus in Finland. Five environmental variables—number of inhabitants, road length, elevation above sea level, proportion of barren bedrock and boulders, and proportion of unsorted glacial deposits—were significant at p ≤ .05, indicating greater between‐species difference in original than in the randomized data. Of these variables, only the optimum value for unsorted glacial deposits was higher for I. persulcatus than for I. ricinus. Maxent models also predicted high relative habitat suitability (suitability >80%) for I. persulcatus south of its current, sharply bounded distribution range, suggesting that the species has not fulfilled its distribution potential in Finland. The two most common and medically relevant ixodids in Finland may colonize habitats with different environmental conditions. On the contrary, the recent establishment and ongoing dispersion of I. persulcatus in Fennoscandia rather than environmental conditions cause the southernmost distribution limit of the species in Finland.
Syn‐rift volcanism in the Barmer Basin: An intra‐basin extrusive complex at the northern limit of the Deccan volcanic province in India
Authors: Burley Stuart D. , Gould Thomas , Taylor Andrew , Mishra Premanand 
Published: December 2022

The Raageshwari Volcanic Formation (RVF) is a volcanic complex in the southern part of the Barmer Basin, NW India, localized around a large rift centre horst block, the Central Basin High. The RVF comprises an initial sequence of acid igneous rocks, which are of ignimbritic origin, termed the Agni Member, overlain by a stacked sequence of basaltic lava flows interbedded with subordinate pyroclastic deposits, the Prithvi Member. Seismic data confirms that the volcanic complex has a conical overall geometry and a layered internal structure produced by successive and extensive flows of basalt and ignimbrite, very similar to that observed in the main Deccan lava outcrops along the western margin of India. U–Pb zircon ages near the top of the Agni Member in the Raageshwari‐26 well give an age of 68+/−2 Ma for a tephrite pyroclastic unit, whilst Ar–Ar analysis of a distal basalt containing phenocrysts of biotite from the Saraswati‐4 well gave an older robust Ar–Ar plateau age of 73.7 ± 1.4 Ma. A typical Deccan age of 67.9 ± 1.7 Ma was obtained from the isolated unaltered basaltic andesite in well NE‐South‐1. Due to depositional on‐lap onto the Central Basin High, the overlying alluvial Dandlawas and Fatehgarh formations are absent on the crest of the Central Basin High and Barmer Hill Formation lake sediments rest directly on the basalts. This relationship indicates that the volcanic cone was a structural or topographic high during deposition onto which the Fatehgarh and Barmer Hill formations lake sediments eventually on‐lapped. The RVF of the Barmer Basin along with the Deccan volcanics in the Cambay Basin, Narmada Rift and in Saurasthra are all developed within fault‐bounded rift basins, in which deep seated faults extend beneath the Deccan volcanic sequence. They are associated with thermal anomalies and thinned continental crust and the presence of a linear low velocity zone at ~100 km depth in the upper mantle region beneath the Barmer and Cambay basins. This is interpreted to be the position of the “conduit” through which plume head material passed through the upper mantle before arriving at the base of the Indian lithosphere. The RVF therefore appears to be an early eruption of differentiated ultrabasic magma from a shallow, secondary magma chamber produced by partial crustal melting.
Using stable water isotopes to understand ecohydrological partitioning under contrasting land uses in a drought‐sensitive rural, lowland catchment
Authors: Landgraf Jessica , Tetzlaff Dörthe , Wu Songjun , Freymüller Jonas , Soulsby Chris 
Published: December 2022

AbstractVegetation plays an essential role in water partitioning, as it strongly influences evapotranspiration, infiltration and water retention. To analyse the influence of vegetation on water partitioning under innovative land management strategies, we used stable water isotopes as natural tracers to monitor precipitation, soil water and groundwater fluxes over the growing season of 2021 (March–October). We selected eight plot sites with four contrasting land covers and soil types in the drought‐sensitive Demnitzer Millcreek Catchment (DMC) in NE Germany. The land use types include forest, grassland, and arable with the latter being subdivided into conventional (e.g., crops) and innovative (e.g., agroforestry) sites. Two weather stations, a flux tower, and in situ soil moisture monitoring complemented our isotopic data with a hydroclimatic context. The year of 2021 had near‐normal precipitation totals compared to the prolonged drought of 2018–20. Soil water storage was highest at the agricultural sites, while lowest at the forest, though this reflected both the influence of soil properties (as forests dominated sand soils while crops loam soils) and the greater evapotranspiration from forests. We also estimated soil water ages and found the greatest isotopic variability and fastest turnover of water in the upper soils of arable sites. The forest soil water had the most limited variability in isotopic composition and tended to be older, revealing lower levels of groundwater recharge. Conventional and innovative cropping sites were similar to each other, likely due to the early tree development stage in agroforestry schemes under the latter. Our investigation revealed the forest sites are potentially most vulnerable to limited water availability in the DMC and land use changes in agricultural land lacked major differences in ecohydrological fluxes over the study year. The study further underlines the need for long‐term observations of recent adaptive land use changes and drought‐sensitive vegetation to improve our understanding and evolve drought resilient land management strategies considering time lags in impacts and non‐stationarity.
Do stock market fluctuations lead to currency deflation in the South Asian region? Evidence beyond symmetry
Authors: Suleman Muhammad Tahir , Tabash Mosab I. , Sheikh Umaid A. 
Published: December 2022

AbstractThis study explores the role of the asymmetrical influence of stock market reaction to the fluctuations in US dollars against the domestic currencies of the South Asian region. The symmetrical Panel based autoregressive distributed lag model (PARDL) model and panel‐based non‐linear autoregressive distributed lag model (NARDL) model with the Pooled Mean Group Approach (PMG) approach were employed to estimate the impact of stock market bullish and bearish behaviour on local currency variabilities of the South Asian region. The results show that during the pre‐economic recession regime, negative fluctuations in stock indexes had a direct association with exchange rate fluctuations for a longer period. However, after the crisis, both negative and positive stock index shocks have formulated an indirect or inverse association with exchange rate fluctuations. These findings pose important practical implications for the short‐term and long‐term shareholders and financial analysts. Hence, it is recommended that shareholders and financial analysts should base their investment in South Asian stock indices on negative and positive shocks since the non‐linear connectivity between both variables also exhibits regime dependence characteristics.
MoBioTools: A toolkit to setup quantum mechanics/molecular mechanics calculations
Authors: Cárdenas Gustavo , Lucia‐Tamudo Jesús , Mateo‐delaFuente Henar , Palmisano Vito F. , Anguita‐Ortiz Nuria , Ruano Lorena , Pérez‐Barcia Álvaro , Díaz‐Tendero Sergio , Mandado Marcos , Nogueira Juan J. 
Published: December 2022

AbstractWe present a toolkit that allows for the preparation of QM/MM input files from a conformational ensemble of molecular geometries. The package is currently compatible with trajectory and topology files in Amber, CHARMM, GROMACS and NAMD formats, and has the possibility to generate QM/MM input files for Gaussian (09 and 16), Orca (≥4.0), NWChem and (Open)Molcas. The toolkit can be used in command line, so that no programming experience is required, although it presents some features that can also be employed as a python application programming interface. We apply the toolkit in four situations in which different electronic‐structure properties of organic molecules in the presence of a solvent or a complex biological environment are computed: the reduction potential of the nucleobases in acetonitrile, an energy decomposition analysis of tyrosine interacting with water, the absorption spectrum of an azobenzene derivative integrated into a voltage‐gated ion channel, and the absorption and emission spectra of the luciferine/luciferase complex. These examples show that the toolkit can be employed in a manifold of situations for both the electronic ground state and electronically excited states. It also allows for the automatic correction of the active space in the case of CASSCF calculations on an ensemble of geometries, as it is shown for the azobenzene derivative photoswitch case.
Identification of thin and thick gingival phenotypes by two transparency methods: A diagnostic accuracy study
Authors: da Costa Fernanda A. , Perussolo Jeniffer , Dias Debora R. , Araújo Maurício G. 
Published: December 2022

AbstractBackgroundThere is limited information on the diagnostic accuracy of the transparency method to diagnose gingival phenotypes taking into consideration not only the gingival thickness (GT) but also the keratinized tissue width (KTW). Thus, the aim of the present study was to compare the diagnostic accuracy of two transparency methods using a conventional steel probe (SP) and a plastic color‐coded probe (CCP) to identify thin and thick gingival phenotypes.MethodsMaxillary anterior teeth (n = 300) of 50 individuals were included in this study. The GT was measured via transgingival assessment at 2 mm apical to the gingival margin. Tooth sites were subdivided into thin or thick phenotypes according to the corresponding GT, respectively, ≤1 mm and >1 mm. SP and CCP were used to determine the gingival phenotype by the transparency method. The KTW was also evaluated. The diagnostic accuracy of the experimental periodontal probes to identify the thin and thick gingival phenotypes were compared.ResultsOf 300 gingival sites evaluated, 57% (n = 172) were identified as thin (GT: 0.82 ± 0.12 mm, KTW: 4 ± 1.2 mm) and 43% (n = 128) as thick phenotypes (GT: 1.16 ± 0.12 mm, KTW: 4.3 ± 1.3 mm) by the transgingival method. The SP and CCP were very sensitive (>0.94) to identify the thin phenotype, however, less specific (0.35–0.39) to diagnose thick phenotype. The diagnostic accuracy for the SP and CCP was similar, 0.69 and 0.70, respectively.ConclusionThe steel and color‐coded plastic probe were equally effective in identifying thin gingival phenotype at maxillary anterior tooth sites.