bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of non-traditional legumes in the production of high-protein feed on irrigation
Authors: Dronova T N , Burtseva N I , Molokantseva E I , Golovatyuk O V , Zemtsova I P 
Published: August 2022

Abstract
The article presents the results of research on the perennial legumes various types modern varieties attracting and adapting to the conditions of the Lower Volga region. The experiments were carried out on irrigated light chestnut soils. The completeness of the studied grasses seedlings was at the level of the traditional culture of purple hybrid alfalfa or slightly lower than its indicators. The creation of optimal growing conditions contributed to the formation of the maximum assimilation surface on the grasses sowing. In the second year of life, the leaf area by crops varied from 43 - 45 to 57 - 62 thousand m2/ha. The highest indices were in alfalfa and blue hybrid alfalfa and meadow clover. On these crops, the yield of green mass was formed at the level of 75 - 88, on the crops of birdsfoot trefoil and creeping crown vetch it was 62 - 65 t/ha. The qualitative indicators of the biomass of the studied legumes corresponded to the high requirements for the assessment of feed. The content of feed units in a kilogram of dry matter was 0.62 - 0.68, digestible protein - 120 - 171, and metabolizable energy - 9.7 - 10.3 MJ. Leguminous herbs improve soil fertility due to the nutrients contained in the accumulated root mass. After three years of use, from 142 to 240 kg of nitrogen, 60 to 90 kg of phosphorus and 80 to 145 kg of potassium enter the soil along with the organic matter.
Regional food systems: assessment of the level of self-sufficiency in food
Authors: Antamoshkina E N , Lutsenko Ja V , Daeva T V , Radionova E A , Sahakyan M A 
Published: August 2022

Abstract
The article reviews characteristics of food system as part of the model of regional agricultural production. The authors consider groups of indicators used to analyze regional food systems: indicators that specify food self-sufficiency of regional markets and the level of interregional food exchange. In the study, based on official statistical data, the level of self-sufficiency in food was assessed on the example of the regions of the Southern Federal District (SFD). As a result of the analysis, the authors found out that in 2019 only a number of regions of the Southern Federal District, in particular, the Republic of Adygea, the Krasnodar Territory, and the Volgograd Region provided a high level of self-sufficiency in food products. Empirical significance of assessing the indicators of regional food systems functioning and food security monitoring is defined by the relevancy to forecast the need for food for the population in the regions of Russia.
Durability increasing by developing a conceptual model for the chisel tool working bodies rational structuring
Authors: Gapich D S , Motorin V A , Veselova N M , Shiryaeva E V 
Published: August 2022

Abstract
There are three main zones with different functional purposes in any tillage machines working bodies design. The technological process being performed determines the functionality of these zones. The first zone is the working area of the nose part, its main task is to destroy the processed material and to apply the main working body into its layers. The second zone is the transition zone, it is an intermediate part of the working body that connects the working area of the working body and the zone responsible for attaching the working body to the tine of the tillage implement. The third zone is the area of the working body attachment. Depending on the functional purpose, the zones of the working organs perceive different external loads. The paper proposes a stepwise hardening technology, which made it possible to carry out the entire complex of technological operations from one volumetric workpiece heating, which allows to reduce the labor intensity of multi-stage heat treatment and the cost of the working body manufacturing. Technologically, it is as follows, the working bodies’ workpieces are placed in fixing frames with special holes, where their wedge-shaped part is recessed. Analysis and experimental verification showed that the heat reserve accumulated in the main part of the working body when heated in the furnace is sufficient for the bainite transformation to occur during intermittently cyclic cooling of the chisel cutting part.
Sudan grass cultivation parameters optimization in the nizhneje povolzje dry-steppe zone
Authors: Laptina Y A , Gichenkova O G , Kulikova N A 
Published: August 2022

Abstract
The article reflects the results of five-year researches in the conditions of light chestnut soils of the Volgograd region to study the ways to increase photosynthetic indicators and yield of Sudan grass of the Allegory variety green mass through the use of mineral fertilizers and pre-sowing seed treatment. The experiment scheme included the following options: 1. Control variant without fertilizers; 2. N120P120K90 +N30; 3.Raykat Start; 4. N120P120K90 +N30+Raikat Start + N30. The seeding rate was 3.0 million of viable seeds per hectare. For all the mineral fertilizers application variants, the dynamics of the increase in the leaf surface area and photosynthetic material was noted. The study of the different nutrition levels influence on the Sudan grass green mass productivity showed the advantage of the option with the combined use of the Raikat Start growth stimulator and mineral fertilizers, this allows to get the increase in comparison with the control variant in the amount of 26 t/ha for three mowings. The application of mineral fertilizers provided the increase of 17.5 t/ha. According to the variant with using only Raikat Start, the increase was 7.4 t/ha.
New Marketing Communications to Promote Agricultural Products to Foreign Markets
Authors: Voytyuk V A , Marinchenko T E , Voytyuk M M 
Published: August 2022

Abstract
The widespread development of the Internet has allowed the use of information and communication technologies and transformed the traditional methods of promoting products in the domestic and foreign markets. Against the background of the general trend towards individualization in working with consumers, information and communication technologies are becoming more widespread in order to expand communication and receive feedback from the end user. At the present stage of development, marketing is becoming one of the conditions for successful functioning in market conditions for enterprises in the agricultural sector. The advancement of communication technologies and their widespread adoption have prompted agricultural producers and retailers to explore various online resources and channels of communication with consumers and use them to promote their products. The paper examines the experience of using various types of marketing communications to promote agricultural products for export and analyzes their potential and prospects for use by domestic producers.
Assessment of food self-sufficiency in the system of diagnostics of food security
Authors: Antamoshkina E N , Krivtsov I V , Smolyakov P P , Snapkouskaya S V , Pechnikov G A 
Published: August 2022

Abstract
The article proposes a complex indicator - the food self-sufficiency index (IFSS). The threshold values of the indicator are established, allowing classification of food provision at the regional level. An integral indicator, the food security index (IFP), which takes into account groups of indicators in the field of production, distribution and consumption of food products, was developed as a methodological analysis tool. In order to analyze the differentiation of regions in food supply, an original methodological toolkit is proposed - a food supply matrix, which makes it possible to rank regions. Based on the conducted economic and statistical analysis of the indicators of food self-sufficiency in the regions of the Southern Federal District (SFD), it was found that the food self-sufficiency index in 2018 corresponded to the optimal level. The proposed method of economic and statistical analysis can be used when conducting socio-economic zoning of regions according to the criteria of food provision in regional markets.
Behavioral design practical application: product policy, public opinion
Authors: Skokov R Yu 
Published: August 2022

Abstract
Behavioral product design is critical to integrated product policy and opens up new opportunities for manufacturers, consumers and society in whole. Behavioral design theory since the 90s of the XIX century evolved as a synthesis of physiological theory of reflexes and reinforcement, psychoanalytic theory of the crowd and operational conditioning, theories of public opinion management and organizational change, institutional concepts of consumer behavior, computerization and the development of data networks. In foreign practice, behavioral design is used in building human interaction with digital devices, architecture, reducing the crime rate, protecting against errors in organizing processes in healthcare, creating energy-saving and resource-saving products, creating eco-friendly products, increasing the safety of using products, solving problems associated with coronavirus, reduction of screen time, impact on public opinion, creation of virtual products for healthcare, education, welfare. In Russian practice, the potential of behavioral design is not realized. The research methodology is based on the combination of classical and multidisciplinary scientific approaches, including methods of behavioral economics, institutionalism and consumer marketing.
Multi-omics therapeutic perspective on ACVR1 gene: from genetic alterations to potential targeting
Authors: Nagar Garima , Mittal Pooja , Gupta Shradheya R R , Pahuja Monika , Sanger Manisha , Mishra Ruby , Singh Archana , Singh Indrakant Kumar 
Published: August 2022

AbstractActivin A receptor type I (ACVR1), a transmembrane serine/threonine kinase, belongs to the transforming growth factor-β superfamily, which signals via phosphorylating the downstream effectors and SMAD transcription factors. Its central role in several biological processes and intracellular signaling is well known. Genetic variation in ACVR1 has been associated with a rare disease, fibrodysplasia ossificans progressive, and its somatic alteration is reported in rare cancer diffuse intrinsic pontine glioma. Furthermore, altered expression or variation of ACVR1 is associated with multiple pathologies such as polycystic ovary syndrome, congenital heart defects, diffuse idiopathic skeletal hyperostosis, posterior fossa ependymoma and other malignancies. Recent advancements have witnessed ACVR1 as a potential pharmacological target, and divergent promising approaches for its therapeutic targeting have been explored. This review highlights the structural and functional characteristics of receptor ACVR1, associated signaling pathways, genetic variants in several diseases and cancers, protein–protein interaction, gene expression, regulatory miRNA prediction and potential therapeutic targeting approaches. The comprehensive knowledge will offer new horizons and insights into future strategies harnessing its therapeutic potential.
Principal microbial groups: compositional alternative to phylogenetic grouping of microbiome data
Authors: Boyraz Aslı , Pawlowsky-Glahn Vera , Egozcue Juan José , Acar Aybar Can 
Published: August 2022

AbstractStatistical and machine learning techniques based on relative abundances have been used to predict health conditions and to identify microbial biomarkers. However, high dimensionality, sparsity and the compositional nature of microbiome data represent statistical challenges. On the other hand, the taxon grouping allows summarizing microbiome abundance with a coarser resolution in a lower dimension, but it presents new challenges when correlating taxa with a disease. In this work, we present a novel approach that groups Operational Taxonomical Units (OTUs) based only on relative abundances as an alternative to taxon grouping. The proposed procedure acknowledges the compositional data making use of principal balances. The identified groups are called Principal Microbial Groups (PMGs). The procedure reduces the need for user-defined aggregation of $\textrm{OTU}$s and offers the possibility of working with coarse group of $\textrm{OTU}$s, which are not present in a phylogenetic tree. PMGs can be used for two different goals: (1) as a dimensionality reduction method for compositional data, (2) as an aggregation procedure that provides an alternative to taxon grouping for construction of microbial balances afterward used for disease prediction. We illustrate the procedure with a cirrhosis study data. PMGs provide a coherent data analysis for the search of biomarkers in human microbiota. The source code and demo data for PMGs are available at: https://github.com/asliboyraz/PMGs.
Identifying and characterizing drug sensitivity-related lncRNA-TF-gene regulatory triplets
Authors: Hu Congxue , Xu Yingqi , Li Feng , Mi Wanqi , Yu He , Wang Xinran , Wen Xin , Chen Shuaijun , Li Xia , Xu Yanjun , Zhang Yunpeng 
Published: August 2022

AbstractRecently, many studies have shown that lncRNA can mediate the regulation of TF-gene in drug sensitivity. However, there is still a lack of systematic identification of lncRNA-TF-gene regulatory triplets for drug sensitivity. In this study, we propose a novel analytic approach to systematically identify the lncRNA-TF-gene regulatory triplets related to the drug sensitivity by integrating transcriptome data and drug sensitivity data. Totally, 1570 drug sensitivity-related lncRNA-TF-gene triplets were identified, and 16 307 relationships were formed between drugs and triplets. Then, a comprehensive characterization was performed. Drug sensitivity-related triplets affect a variety of biological functions including drug response-related pathways. Phenotypic similarity analysis showed that the drugs with many shared triplets had high similarity in their two-dimensional structures and indications. In addition, Network analysis revealed the diverse regulation mechanism of lncRNAs in different drugs. Also, survival analysis indicated that lncRNA-TF-gene triplets related to the drug sensitivity could be candidate prognostic biomarkers for clinical applications. Next, using the random walk algorithm, the results of which we screen therapeutic drugs for patients across three cancer types showed high accuracy in the drug-cell line heterogeneity network based on the identified triplets. Besides, we developed a user-friendly web interface-DrugSETs (http://bio-bigdata.hrbmu.edu.cn/DrugSETs/) available to explore 1570 lncRNA-TF-gene triplets relevant with 282 drugs. It can also submit a patient’s expression profile to predict therapeutic drugs conveniently. In summary, our research may promote the study of lncRNAs in the drug resistance mechanism and improve the effectiveness of treatment.
Two subtypes of schizophrenia identified by an individual-level atypical pattern of tensor-based morphometric measurement
Authors: Shi Weiyang , Fan Lingzhong , Wang Haiyan , Liu Bing , Li Wen , Li Jin , Cheng Luqi , Chu Congying , Song Ming , Sui Jing , Luo Na , Cui Yue , Dong Zhenwei , Lu Yuheng , Ma Yawei , Ma Liang , Li Kaixin , Chen Jun , Chen Yunchun , Guo Hua , Li Peng , Lu Lin , Lv Luxian , Wan Ping , Wang Huaning , Wang Huiling , Yan Hao , Yan Jun , Yang Yongfeng , Zhang Hongxing , Zhang Dai , Jiang Tianzi 
Published: August 2022

AbstractDifficulties in parsing the multiaspect heterogeneity of schizophrenia (SCZ) based on current nosology highlight the need to subtype SCZ using objective biomarkers. Here, utilizing a large-scale multisite SCZ dataset, we identified and validated 2 neuroanatomical subtypes with individual-level abnormal patterns of the tensor-based morphometric measurement. Remarkably, compared with subtype 1, which showed moderate deficits of some subcortical nuclei and an enlarged striatum and cerebellum, subtype 2, which showed cerebellar atrophy and more severe subcortical nuclei atrophy, had a higher subscale score of negative symptoms, which is considered to be a core aspect of SCZ and is associated with functional outcome. Moreover, with the neuroimaging–clinic association analysis, we explored the detailed relationship between the heterogeneity of clinical symptoms and the heterogeneous abnormal neuroanatomical patterns with respect to the 2 subtypes. And the neuroimaging–transcription association analysis highlighted several potential heterogeneous biological factors that may underlie the subtypes. Our work provided an effective framework for investigating the heterogeneity of SCZ from multilevel aspects and may provide new insights for precision psychiatry.
The Performance of Computer-Aided Detection Digital Chest X-ray Reading Technologies for Triage of Active Tuberculosis Among Persons With a History of Previous Tuberculosis
Authors: Kagujje Mary , Kerkhoff Andrew D , Nteeni Mutinta , Dunn Ian , Mateyo Kondwelani , Muyoyeta Monde 
Published: August 2022

Abstract

Background
Digital chest X-ray (dCXR) computer-aided detection (CAD) technology uses lung shape and texture analysis to determine the probability of tuberculosis (TB). However, many patients with previously treated TB have sequelae, which also distort lung shape and texture. We evaluated the diagnostic performance of 2 CAD systems for triage of active TB in patients with previously treated TB.

Methods
We conducted a retrospective analysis of data from a cross-sectional active TB case finding study. Participants ≥15 years, with ≥1 current TB symptom and complete data on history of previous TB, dCXR, and TB microbiological reference (Xpert MTB/RIF) were included. dCXRs were evaluated using CAD4TB (v.7.0) and qXR (v.3.0). We determined the diagnostic accuracy of both systems, overall and stratified by history of TB, using a single threshold for each system that achieved 90% sensitivity and maximized specificity in the overall population.

Results
Of 1884 participants, 452 (24.0%) had a history of previous TB. Prevalence of microbiologically confirmed TB among those with and without history of previous TB was 12.4% and 16.9%, respectively. Using CAD4TB, sensitivity and specificity were 89.3% (95% CI: 78.1–96.0%) and 24.0% (19.9–28.5%) and 90.5% (86.1–93.3%) and 60.3% (57.4–63.0%) among those with and without previous TB, respectively. Using qXR, sensitivity and specificity were 94.6% (95% CI: 85.1–98.9%) and 22.2% (18.2–26.6%) and 89.7% (85.1–93.2%) and 61.8% (58.9–64.5%) among those with and without previous TB, respectively.

Conclusions
The performance of CAD systems as a TB triage tool is decreased among persons previously treated for TB.
Manual and mechanical stripping-induced enamel roughness and elemental composition in vivo
Authors: Katsigialou Niki , Sifakakis Iosif , Zinelis Spiros , Papageorgiou Spyridon N , Eliades Theodore 
Published: August 2022

Summary

Objectives
Interproximal enamel reduction (IPR) is routinely used in orthodontics to generate small to moderate amounts of space within the dental arch. Aim of this ex vivo study was to evaluate the effect of two different IPR systems on the enamel surface’s waviness, roughness, and elemental composition after 6 months of intraoral exposure.

Materials and methods
Fifteen orthodontic extraction patients were included in the present study. The 39 healthy premolars, which were scheduled to be extracted, were subjected to IPR at least 6 months before their extraction. IPR was performed on their mesial side with two different methods: (1) instrumented method with the Ortho-Strips system (on handpiece) and (2) manually with the Intensiv ProxoStrip (strips)—each with four different grits for contouring, finishing, and polishing. The distal side of each premolar served as its own internal control. Treated and untreated tooth surfaces were evaluated by optical profilometry, Raman, and scanning electron microscope/X-ray energy-dispersive (EDX) analyses. Data were analysed with descriptive statistics and generalized linear models at alpha = 5%.

Results
Both IPR methods significantly reduced the waviness of the enamel surface (P &lt; 0.001), with manual IPR leading to smaller waviness reductions than the instrumented IPR (P ≤ 0.001). On the other side, both IPR methods led to a significant increase in enamel surface roughness (P &lt; 0.001), with no significant differences between IPR methods. EDX and Raman analyses did not demonstrate any alterations on elemental composition of enamel after at least 6 months of intraoral exposure.

Conclusions
Both stripping systems led to a flatter but rougher enamel surface. Further polishing is needed to restore the initial enamel smoothness. The elemental composition of the stripped enamel returns to the baseline level after 6 months of intraoral exposure.
Availability and implementation of guidelines in European child primary health care: how can we improve?
Authors: Kocken Paul L , van Kesteren Nicole M C , van Zoonen Renate , Reijneveld Sijmen A 
Published: August 2022

Abstract

Background
Clinical guidelines are important for providing high-quality child primary health care. We aimed to assess the availability, use and achieved delivery of guidelines in the European Union (EU).

Methods
We used a case study design to ascertain expert views on guidelines in six countries representing the EU. The experts completed an online questionnaire (response 49%), asking about their perception of guideline availability and implementation regarding three topics that represent prevention and care, i.e. vaccination, assessment of mental health and asthma care.

Results
According to the respondents all countries had guidelines available for asthma care. For vaccination and mental health assessment respondents agreed to a lesser degree that guidelines were available. Implementation of guidelines for vaccination was mostly perceived as intended, but implementation of the guidelines for mental health assessment and asthma care was limited. Notable barriers were complexity of performance, and lack of training of professionals and of financial resources. Important facilitators for guideline implementation were the fit with routine practice, knowledge and skills of professionals and policy support. We found no clear relationship of guideline availability and implementation with type of child primary health care system of countries, but strong governance and sufficient financial resources seemed important for guideline availability.

Conclusions
Availability and implementation of clinical guidelines in child primary health care vary between EU countries. Implementation conditions can be strongly improved by adequate training of professionals, stronger governance and sufficient financial resources as facilitating factors. This can yield major gains in child health across Europe.