bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basal Cell Carcinoma. Historical Aspects, Current Achievements and Problems at the Nowadays
Authors: Лапасов О.А. , Заславский Д.В. , Сыдиков А.А. , Пягай Г.Б. , Козлова Д.В. , Гунченко И.В. 
Published: April 2022

Базальноклеточный рак кожи по распространенности занимает первое место в структуре злокачественных новообразований кожи. Первые упоминания о нозологии встречаются еще в третьем тысячелетии до нашей эры. На протяжении столетий терапией выбора было местное воздействие на опухоль, которое начиналось с прижигания и переросло в хирургическое иссечение, на сегодняшний день являющееся«золотым стандартом». С развитием диагностических возможностей в медицине специалисты стали изучать клинические формы и гистогенез базальноклеточной карциномы для усовершенствования скорости и точности ее выявления и лечения. Так, в дебюте базальноклеточный рак кожи может быть клинически идентичен плоскоклеточному раку, актиническому кератозу, болезни Боуэна, а также некоторым воспалительным дерматозам. Как известно, базальноклеточный рак крайне редко метастазирует и сопровождается чрезвычайно низкой смертностью, но опасен локальной инвазией и разрушением близлежащих органов и тканей. Ранняя диагностика и своевременное начало курации пациента позволят избежать распространения тканевых повреждений, ускорят лечение и улучшат его качество. Поэтому поиск точных и простых диагностических критериев – это цель изучения базальноклеточного рака кожи современным дерматологическим научным сообществом.
Basal cell carcinoma ranks first in terms of prevalence in the statistical structure of skin malignant neoplasms. The first mentions of nosology were found in the third millennium BC. For centuries, the therapy of choice has been local treatment of the tumor, which began with cauterization and developed into surgical excision, which is considered as the gold standard nowadays. With the development of diagnostic capabilities in medicine, specialists began to study the clinical forms and histogenesis of tumors to improve the speed and accuracy of tumor detection and treatment. So, at the onset, basal cell skin cancer can be clinically identical to squamous cell carcinoma, actinic keratosis, Bowen’s disease, and inflammatory dermatoses. Basal cell carcinoma rarely metastases and is accompanied by extremely low mortality, but it is dangerous by local invasion and destruction of nearby organs and tissues. Early diagnosis and start of patient supervision will avoid the spread of tissue damage, accelerate and improve the quality of treatment. Therefore, the search for accurate and simple diagnostic criteria is the goal of studying basal cell skin cancer of the modern dermatological scientific community.
A clinical Сase of Late Diagnosis of Chronic Non-healing Cutaneous Leishmaniasis
Authors: Колдарова Э.В. , Мухамедов Б.И. , Курбанов О.Ж. , Сыдиков А.А. 
Published: April 2022

В статье представлены литературные данные по лейшманиозу: описаны основные формы лейшманиоза, клинические проявления, методы диагностики и лечения. Представлен клинический случай поздней диагностики хронического незаживающего кожного лейшманиоза.
The article presents the literature data on leishmaniasis: the main forms of leishmaniasis, clinical manifestations, methods of diagnosis and treatment are described. A clinical case of late diagnosis of chronic non-healing cutaneous leishmaniasis is presented.
Isolasi dan Uji Aktivitas Antibakteri dari Jamur Endofit Daun Leilem (Clerodendrum minahassae L.)
Authors: Angelin Milce , Endey Bella , Patading Gea Fani , Kolondam Beivy Jonathan , Tangapo Agustina Monalisa 
Published: April 2022

Infectious diseases suffered by many people are caused by several bacteria such as Escherichia coli, Staphylococcus aureus, Salmonella thyphi, Pseudomonas aeruginosa, Shigella dysenteriae, Vibrio cholera and Streptococcus mutans. Endophytic fungi can produce the same bioactive compounds as their host. The purpose of this study was to characterize macroscopically and microscopically endophytic fungi from the endemic plant of North Sulawesi leilem leaf (C. minahassae) and to examine the potential antibacterial activity of the endophytic fungus leilem leaf against pathogenic bacteria. The method used for the antibacterial test is the modified Kirby-bauer method. The results of this study, obtained 13 isolates of leilem leaf endophytic fungi that were isolated and characterized macroscopically and microscopically, namely JDL 7, JDL 10, JDL 12, JDL 16, JDL 17, JDL 18, JDL 20, JDL 21, JDL 22, JDL. 24, JDL 26, JDL 28. Four isolates of endophytic fungi that were effective as antibacterials were isolates JDL 8, JDL 26, JDL 28 against E. coli and JDL 18, JDL 26, JDL 28 against S. aureus. The endophytic fungal isolates which had the highest inhibition zone against E. coli were indicated by the isolate code JDL 26 with an average inhibition zone of 27 mm, while for S. aureus, the highest inhibition zone was indicated by the isolate code JDL 26 with an average inhibition zone of 29 mm.Keywords: Isolation, Leilem leaf, endophytic fungi, antibacterial Abstrak Penyakit infeksi yang banyak diderita masyarakat disebabkan oleh beberapa bakteri seperti Escherichia coli, Staphylococcus aureus, Salmonella thyphi, Pseudomonas aeruginosa, Shigella dysenteriae, Vibrio cholera dan Streptococcus mutans. Jamur endofit dapat menghasilkan senyawa-senyawa bioaktif yang sama dengan inangnya. Tujuan penelitian ini adalah untuk mengarakterisasi secara makroskopis dan mikroskopis jamur endofit dari tumbuhan endemik Sulawesi Utara daun leilem (C. minahassae) serta menguji potensi aktivitas antibakteri dari jamur endofit daun leilem terhadap bakteri patogen. Metode yang digunakan untuk uji antibakteri adalah metode Kirby-bauer. Hasil penelitian ini, diperoleh 13 isolat jamur endofit daun leilem yang berhasil diisolasi dan dikarakterisasi secara makroskopis dan mikroskopis, yaitu JDL 7, JDL 10, JDL 12, JDL 16, JDL 17, JDL 18, JDL 20, JDL 21, JDL 22, JDL 24, JDL 26, JDL 28. Empat isolat jamur endofit yang efektif sebagai antibakteri yaitu isolat JDL 8, JDL 26, JDL 28 terhadap E. coli dan JDL 18, JDL 26, JDL 28 terhadap bakteri S. aureus. Isolat jamur endofit yang memiliki zona hambat tertinggi terhadap bakteri E. coli ditunjukkan pada kode isolat JDL 26 dengan rerata zona hambat 27 mm sedangkan untuk bakteri S. aureus, zona hambat tertinggi ditunjukkan pada kode isolat JDL 26 dengan rerata zona hambat 29 mm.Kata kunci: Isolasi, daun Leilem, jamur endofit, antibakteri
New CCD Astrometric Observations of Himalia Using Gaia DR2 in 2015–2021
Authors: Shang Y. J. , Peng Q. Y. , Zheng Z. J. , Vienne A. , Guo B. F. , Lin F. R. , Chen Y. 
Published: April 2022

Abstract
The long arc and high-quality astrometric measurements of outer irregular satellites are prerequisites for improving their orbital theories and increasing the precision of their ephemerides. In order to obtain good astrometric positions of Himalia, the largest irregular satellite of Jupiter, we have processed and reduced 911 ground-based CCD frames obtained between 2015 and 2021 by three telescopes (including 1 and 2.4 m telescopes at Yunnan Observatory, and 0.8 m telescope at Purple Mountain Observatory) over 61 nights. Subtracting off the companion star of our target by constructing an effective point-spread function (ePSF) model in some CCD frames, the ePSF-subtracted technique is used to reduce the centering error. Some additional techniques are applied in data reduction to further improve positional accuracy and precision of Himalia. This includes geometric distortion correction, weighted polynomial plate models, and the precision-premium effect, since their relative positional measurements have better precision when two objects are very near (e.g., less than 60″). The star catalog Gaia DR2 is used for astrometric calibration, and theoretical positions of Himalia are retrieved from JPL Horizons ephemeris, including the satellite ephemeris Jup344 and the newest planetary ephemeris DE441. Our results show the mean (O − C)s (observed minus computed) of the positional residuals of Himalia are −0."004 and 0.″005 in R.A. and decl., respectively, and their corresponding standard deviations are about 0.″020 in each direction.
The Accurate Mass Distribution of M87, the Giant Galaxy with Imaged Shadow of Its Supermassive Black Hole, as a Portal to New Physics
Authors: De Laurentis Mariafelicia , Salucci Paolo 
Published: April 2022

Abstract
The very careful Event Horizon Telescope estimate of the mass of the supermassive black hole at the center of the giant cD galaxy M87, allied with recent high-quality photometric and spectroscopic measurements, yields a proper dark/luminous mass decomposition from the galaxy center to its virial radius. That provides us with decisive information on crucial cosmological and astrophysical issues. The dark and the standard matter distributions in a wide first time detected galaxy region under the supermassive black hole gravitational control. The well-known supermassive black hole mass versus stellar dispersion velocity relationship at the highest galaxy masses implies an exotic growth of the former. This may be the first case in which one can argue that the supermassive black hole mass growth was also contributed by the dark matter component. A huge dark matter halo core in a galaxy with inefficient baryonic feedback is present and consequently constrains the nature of the dark halo particles. The unexplained entanglement between dark/luminous structural properties, already emerged in disk systems, also appears.
Characteristic of Streptozotocin-Nicotinamide-Induced Inflammation in A Rat Model of Diabetes-Associated Renal Injury
Authors: Sasongko Heru , Nurrochmad Arief , Rohman Abdul , Nugroho Agung Endro 
Published: April 2022

Background: Chemical agents such as streptozotocin (STZ) and nicotinamide (NAD) are used in animal models of diabetes mellitus and their related consequences in the kidneys. Several studies have been conducted to determine the modeling, however, the results are still unclear. Moreover, diabetic nephropathy is considered to begin with an inflammatory reaction in the kidneys. Objectives: This study aims to investigate the metabolic profile STZ and NAD induce inflammation in the kidney. Methods: The male Wistar rats used were divided into control and STZ-induced diabetes. Half of the diabetes group received a single dose of nicotinamide (230 mg/Kg) 15 minutes after STZ injection and all groups were monitored for 6 weeks. Furthermore, the profiles of creatinine, urea, and uric acid from serum and urine were observed and the kidney inflammation was tested by immunohistochemistry (IHC) with IL-6 and TNF-α parameters. Results: The result shows that the administration of a single dose of 230 mg/kg NAD in diabetic rats induced with 50 mg/kg and 65 mg/kg STZ affects body weight and kidney organ index. For 6 weeks of testing, both doses of STZ were enhanced several parameters of kidney damage in diabetic rats in blood and urine chemical parameters. Furthermore, the use of NAD to promote inflammation in STZ-induced diabetic rats gave no significant difference. However, NAD can help mice live longer and avoid problems throughout the test. Conclusions: The use of NAD leads to inflammation in Streptozotocin-induced diabetic rats. Therefore, the administration of Nicotinamide is recommended since it helps the rats live longer during the experiment.
Le renversement des rôles : un « reflet » plutôt négligé de l’héritage du passé
Authors: Borgogno Franco , Vigna-Taglianti Massimo , Angelini Rota Antonella 
Published: April 2022

Les auteurs explorent, du point de vue théorique et clinique, le phénomène du renversement des rôles, une forme particulière de répétition transférentielle – plutôt négligée par notre littérature – qui peut se représenter de manière plus ou moins continue sur le scénario analytique à travers l’identification inconsciente du patient aux défenses et à la culture psychique du parent, avec une dissociation concomitante d’aspects souffrants de son Soi infantile dans l’analyste. Deux brèves vignettes cliniques illustrent quelques-unes des modalités avec lesquelles ce processus inter/intrapsychique est mis en œuvre dans l’« onde longue » du traitement analytique, et la nécessaire « inter- acting cure » qui en découle pour amener le patient à accéder à « son cœur dissocié », et favoriser « la cicatrisation de ses blessures psychiques » et l’entrée dans l’univers symbolique partagé.
Le temps du conte dans la thérapie post-traumatique
Authors: de Bérail Brune 
Published: April 2022

Au confluent de la narratologie et de la psychologie, le concept de narrativité est un outil thérapeutique primordial. Dans le cadre de thérapies post-traumatiques, le thérapeute est l’interlocuteur dont l’écoute soutient les fonctions de l’enveloppe narrative du patient : cette élaboration qui transforme les éléments bruts d’un réel effractant en éléments pensables puise dans la vie fantasmatique qui préexistait à l’événement traumatique. Ces « mythèmes » organisateurs sont venus nourrir la structuration de ces contes à usage privé qui se construisent dans le cadre de la thérapie. Mais ce travail engage un jeu particulier où les identités du témoin, de la victime et du coupable sont floues. Patient et thérapeute se retrouvent au coeur d’une valse-hésitation d’identifications projectives qu’il est nécessaire d’analyser.
Un monde en développement de plus en plus inégal
Authors: Lautier Marc , Quenault Béatrice , Gérardin Hubert 
Published: April 2022

Les inégalités sont au cœur des processus de développement à l’échelle de la planète. L’article examine les relations inégalités-développement sur la longue période et leurs évolutions quantitatives au fil de l’essor différencié des pays du Nord et du Sud, dans un contexte marqué par la mondialisation des échanges et la globalisation financière, à l’origine de profonds changements dans les chaînes de valeurs et les trajectoires de développement national. Malgré les difficultés d’appréhension des inégalités sociales et environnementales, le plus souvent de natures qualitatives, l’évolution des rapports sociaux et du changement climatique en renforcent l’évidence. Classification JEL : N10, O10, O15, I 32
Violation des droits des femmes et malnutrition en Inde : vers de nouvelles formes d’inégalités ?
Authors: Alvarez-Saavedra Valentina , Levasseur Pierre , Seetahul Suneha 
Published: April 2022

À partir de données longitudinales sur la population indienne, nous estimons la façon dont l’accroissement des discriminations envers les femmes affecte leur santé nutritionnelle. Tandis que certaines formes de discriminations en Inde se sont détériorées sur la période étudiée, nous observons systématiquement des effets non linéaires de ces changements sur l’état nutritionnel des femmes, suggérant la concomitance de différents mécanismes ayant des conséquences nutritionnelles diamétralement opposées (prise de poids versus perte de poids). Classification JEL : I14, J16
Repeatability and Comparison of Corneal Tomography in Mild to Severe Keratoconus Between the Anterior Segment OCT MS-39 and Pentacam HR
Authors: Seiler Theo G. , Mueller Maya , Mendes Baiao Tiago 
Published: April 2022

PURPOSE:
To detect keratoconus progression, accuracy of tomographic measurements is crucial. The impoved axial resolution of optical coherence tomography (OCT) compared to Scheimpflug photography serves as the motivation to investigate and compare the repeatability of the anterior segment OCT MS-39 (CSO) to Pentacam HR (Oculus Optikgeräte GmbH) in patients with keratoconus.

METHODS:

One hundred twenty-three eyes of 123 patients with keratoconus were enrolled and subdivided in four groups by maximum keratometry (Kmax): Kmax < 48.00 diopters (D), Kmax of 48.00 to 53.01 D, Kmax of 53.00 to 58.00 D, and Kmax > 58.00 D. Three consecutive measurements per eye were acquired with the MS-39 and compared to the Pentacam HR. Kmax, thinnest pachymetry, anterior asphericity, and posterior elevation data were compared. Within-subject standard deviation (S
w
), coefficient of variation (CoV), test–retest repeatability (TRT), and the intra-class correlation (ICC) were calculated and evaluated. Bland–Altman plots were also analyzed.

RESULTS:

The Pentacam HR measures significantly higher Kmax values than the MS-39, with a more pronounced difference for severe cases of keratoconus (0.57 D for all cases; 1.88 D for cases with Kmax > 58.00 D). Thinnest pachymetry was approximately 5 µm thinner when measured by the Pentacam HR than the MS-39, independently of keratoconus stage. A further progressed keratoconus stage was significantly associated with increased measurement errors and resulted in worse repeatability (Kmax < 48.00 D: S
w
= 0.18 D, TRT = 0.50 D, CoV = 0.39%, ICC = 0.989; Kmax > 58.00 D: S
w
= 0.53 D, TRT = 1.48 D, CoV = 0.90%, ICC = 0.984). The behavior was similar for other tomographic parameters.

CONCLUSIONS:
The Pentacam HR and the MS-39 have an overall good agreement for keratoconus; however, the Pentacam HR measures steeper and thinner than the MS-39. The association between the magnitude of topographic and tomographic parameters and their measurement errors suggests that the diagnosis of keratoconus disease progression should be based on the stage and the test-retest repeatability rather than on a fixed value (eg, 1.00 D).

[
J Refract Surg
. 2022;38(4):250–255.]
Exploitation du consommateur et aliénation du client. La sphère domestique comme espace de création de valeur économique et symbolique
Authors: Perronet Alexandra 
Published: April 2022

La phase actuelle d’accumulation capitalistique tend à faire de la consommation non seulement une sphère de reproduction des rapports sociaux, mais un lieu de production des forces de travail. Partant de ce postulat, cet article se propose de montrer comment les pratiques de consommation structurent les rapports sociaux de production. Selon l’auteur, il s’agit d’une question à la fois pratique et symbolique : la consommation détermine tant l’organisation des rapports sociaux que le développement d’un imaginaire social.
Alantolactone and ZnO nanoparticles induce apoptosis activity of cisplatin in an ovarian cancer cell line (SKOV3)
Authors: Alipour Shahriar , Babaei Ghader , Gholizadeh-Ghaleh Aziz Shiva , Abolhasani Somayeh 
Published: April 2022

Background and purpose:
Ovarian cancer is one of the leading causes of cancer mortality in women. Despite the increase in cases of this cancer, the current therapeutic strategy is not effective. This study aimed to investigate the effect of cisplatin (Cis) with alantolactone (ALT) and ZnO nanoparticles (ZnONPs) in inducing apoptosis in SKOV3 ovarian cancer cells line.

Experimental approach:
To evaluate the viability of SKOV3 cells and determine the IC50 of Cis, ALT, and ZnONPs, MTT assay was used. Real-time PCR and western blotting were used to evaluate the expression levels of genes (XIAP, cyclin D1, Bcl-2, Bax, and MDM2) and proteins (XIAP, cyclin D1, Bcl-2, Bax), respectively. Also, cellular ROS levels were assessed by fluorimetry.

Findings / Results:
Our results showed that ALT and ZnONPs significantly increased the response to Cis in SKOV3 cells compared to the control and this response is remarkably increased in the triple combination (ALT-Cis-ZnONPs). The expression of XIAP, cyclin D1, and Bcl-2 genes and proteins in the groups treated with ALT, Cis, and ZnONPs as a single agent, double and triple combination were significantly reduced compared to the control, while Bax was generally shown an increase. Also, the level of intracellular ROS is higher in the treatment groups than in the control group and the highest increase was observed in the triple combination.

Conclusion and implications:
Taken together, our data demonstrated the potential therapeutic approach of using ALT and ZnONPs that may enhance the apoptotic effects of Cis on the SKOV3 cells.
Maternal and Perinatal Outcome in Covid-19 Complicated Pregnancies in a Level-3 Covid Facility of North India
Authors: Agarwal Neelima , Gupta Manisha , Agrawal Alpana 
Published: April 2022

Background:
Due to its physiologic immune suppression, pregnancy is a vulnerable time for severe respiratory infections including COVID-19. However, information regarding the effect of COVID-19 during pregnancy is limited.

Objectives:
To study the clinical profile of patients suffering from coronavirus disease-2019 (COVID-19) during pregnancy and to evaluate the effect of COVID-19 on maternal, perinatal, and neonatal outcomes.

Methodology:
This is a cross-sectional observational study over a period of one year from June 2020 to May 2021, in Level-3 Covid facility in Ghaziabad. All pregnant females with confirmed positive for Corona virus infection admitted to the covid ward under the department of Obstetrics & Gynecology were included in the study.

Results:
A total of 233 pregnant women were included in the study. Maximum patients were from age group 21-30 years (53.2), multigravida (62.7%), and presented in the third trimester (80.7%). On admission, 198 patients (85%) had no covid related symptoms and only three patients had severe symptoms requiring ICU care. Total 102 patients delivered (43.77%), out of whom 40 had a normal vaginal delivery and 62 had a cesarean section. The incidence of preterm birth was 22.5% and maternal death was in three patients (1.3%).

Conclusion:
The common presentation of COVID-19 during pregnancy is either a mild disease or even asymptomatic. The maternal outcomes observed in late pregnancy and fetal and neonatal outcomes appear good in most cases. Further studies are required to know long-term outcomes and potential intrauterine vertical transmission.
Understanding Same-Sex Relationships in Gay Individuals
Authors: Malick Tanvi , Gupta Aarzoo , Arun Priti 
Published: April 2022

ABSTRACT

Background:
The social demands and pressure often lead individuals of the sexual minority to enter heterosexual marriages resulting in the termination of ongoing same-sex relationships. Consequently, short-lived relations and multiple romantic or sexual partners.

Methods and Material:
The study aimed to assess couple satisfaction in relation to sexual satisfaction, mental health, and stigma in gay individuals. It was a correlational cross-sectional study conducted online through social media platforms using Google Forms. The assessment measures used were: Couple Satisfaction Index, New Sexual Satisfaction Scale, General Health Questionnaire, and Self-Stigma Scale. Out of a total of 115 posts, 92 responses were received from which a sample of 30 was analyzed using Statistical Package for the Social Sciences version 28. Descriptive statistics, Spearman’s correlation, and regression were computed to determine predictors of relationship satisfaction.

Results:
The correlation between sexual satisfaction and couple satisfaction (r = 0.52, P ≤0.01) was significant indicating that sexual satisfaction increases couple satisfaction. Psychological distress and stigma were inversely related to couple satisfaction but not to sexual satisfaction.

Conclusions:
Sexual satisfaction largely determined the couple’s satisfaction while psychological distress or stigma accounts for a small percentage of couple satisfaction.