bluuebunny/crossref_metadata_2025_split huggingface dataset:
When does “inhibition of return” occur in spatial cueing tasks? Temporally disentangling multiple cue-triggered effects using response history and conditional accuracy analyses
Authors: Panis Sven , Schmidt Thomas 
Published: June 2022

Abstract
Research on spatial cueing has shown that uninformative cues often facilitate mean response time (RT) performance in valid- compared to invalid-cueing conditions at short cue-target stimulus-onset-asynchronies (SOAs), and robustly generate a reversed or inhibitory cueing effect at longer SOAs that is widely known as inhibition-of-return (IOR). To study the within-trial time course of the IOR and facilitation effects we employ discrete-time hazard and conditional accuracy analyses to analyze the shapes of the RT and accuracy distributions measured in two experimental tasks. Our distributional analyses show that (a) IOR is present only from ~160 ms to ~280 ms after target onset for cue-target SOAs above ~200 ms, (b) facilitation does not precede IOR, but co-occurs with it, (c) the cue-triggered motor response activation is selectively and actively inhibited before target onset, (d) the IOR effect consists of a facilitatory and an inhibitory component when compared to central cueing, (e) the addition of an extra central cue causes a temporary negative cueing effect in the conditional accuracy functions, and (f) the within-trial time course of IOR is not affected much by the task employed (detection or localization). We conclude that the traditional mean performance measures conceal crucial information on behavioral dynamics in spatial cueing paradigms.
Effects of layup parameters and interference value on the performance of CFRP–metal interference fit joints
Authors: Zhang Jinguang , Huang Yang , Ma Xiangyu , Wen Xianglong , Rao Jun , Dou Yukuan , Zang Meng 
Published: June 2022

Abstract
Based on the thick-wall cylinder theory and composite material mechanics, the stress distribution model of the CFRP shaft tube and metal shaft head has been established, and the relationship between the layup parameters and the value of interference on the maximum assembly force and failure torque in the interference fit joints of the CFRP shaft tube and the metal shaft head is deduced. Combining the three-dimensional finite element analysis model with experimental data, the result shows that the layup angles of the CFRP shaft tube have a greater influence on the joint connection performance than the layup sequence, and the larger the layup angle, the better the joint assembly performance while keeping the value of interference constant. The maximum assembly force and failure torque of the interference fit joints increase linearly while the value of the interference amount increases when the layup parameters are constant.
Effects of estradiol on bone in men undergoing androgen deprivation therapy: a randomized placebo-controlled trial
Authors: Russell Nicholas , Ghasem-Zadeh Ali , Hoermann Rudolf , Cheung Ada S , Zajac Jeffrey D , Shore-Lorenti Cat , Ebeling Peter R , Handelsman David J , Grossmann Mathis 
Published: June 2022

Abstract

Objective
In men, many effects of testosterone (T) on the skeleton are thought to be mediated by estradiol (E2), but trial evidence is largely lacking. This study aimed to determine the effects of E2 on bone health in men in the absence of endogenous T.

Design
This study is a 6-month randomized, placebo-controlled trial with the hypothesis that E2 would slow the decline of volumetric bone mineral density (vBMD) and bone microstructure, maintain areal bone mineral density (aBMD), and reduce bone remodelling.

Methods
78 participants receiving androgen deprivation therapy for prostate cancer were randomized to 0.9 mg of 0.1% E2 gel daily or matched placebo. The outcome measures were vBMD and microarchitecture at the distal tibia and distal radius by high-resolution peripheral quantitative CT, aBMD at the spine and hip by dual-energy x-ray absorptiometry, and serum bone remodelling markers.

Results
For the primary endpoint, total vBMD at the distal tibia, there was no significant difference between groups, mean adjusted difference (MAD) 2.0 mgHA/cm3 (95% CI: −0.8 to 4.8), P = 0.17. Cortical vBMD at the distal radius increased in the E2 group relative to placebo, MAD 14.8 mgHA/cm3 (95% CI: 4.5 to 25.0), P = 0.005. Relative to placebo, E2 increased estimated failure load at tibia, MAD 250 N (95% CI: 36 to 465), P = 0.02, and radius, MAD 193 N (95% CI: 65 to 320), P = 0.003. Relative to placebo, E2 increased aBMD at the lumbar spine, MAD 0.02 g/cm2 (95% CI: 0.01 to 0.03), P = 0.01, and ultra-distal radius, MAD 0.01 g/cm2 (95% CI: 0.00 to 0.02), P = 0.01, and reduced serum bone remodelling markers.

Conclusion
Relative to placebo, E2 treatment increases some measures of bone density and bone strength in men and reduces bone remodelling, effects that occur in the absence of endogenous T.
Evaluation of the Reliability of Electrocardiographic Criteria for Cardiac Hypertrophy Based on Echocardiographic Data
Authors: Augustaitytė Agnė , Kalinauskienė Eglė 
Published: June 2022

Background. Left ventricular hypertrophy (LVH) regardless of other risk factors may be associated with an increased risk of mortality from cardiovascular diseases. Therefore, timely diagnosis for LVH is important in order to avoid possible complications. One of the simplest and cheapest methods to diagnose LVH is electrocardiography (ECG). Although a number of ECG criteria for LVH is known, their reliability varies in many studies.Aim. To evaluate the reliability of ECG criteria for LVH based on transthoracic echocardiography (TTE) data.Methods. The study included all consecutive patients in Kaunas Clinical Hospital Department of Cardiology from December 2019 until March 2020 and from September until October 2020, after applying the inclusion and exclusion criteria. The sensitivity and specificity of the ECG criteria for LVH were assessed based on TTE measurements performed during the same inpatient setting. The reliability of the ECG criteria for LVH was assessed using ROC curves. Reliability differences in gender, age and nutritional status groups were assessed using ANOVA statistical method.Results. Data from 95 patients were analyzed (63.2% were women and 36.8% were men). The sensitivity, specificity and AUC of Sokolow–Lyon criterion were 9.38%, 85.71% and 0.44 (p = 0.034), R in aVL – 6.25%, 90.48% and 0.51 (p = 0.038), Cornell – 21.88%, 100 % and0.69 (p = 0.084), Cornell product – 31.25%, 95.24% and 0.72 (p = 0.070), Peguero–Lo Presti – 31.25%, 85.71% and 0.68 (p = 0.053), respectively. No statistically significant differences were observed among the individual gender, age and nutritional status groups.Conclusions. Sokolow–Lyon and RaVL criteria were not statistically significantly reliable in LVH diagnosis compared to TTE, unlike the Cornell, Cornell product, and Peguero–Lo Presti criteria.
Intervenção psicopedagógica em caso de criança com neurofibromatose tipo 1
Authors: Lumertz Fábia Daniela Schneider 
Published: June 2022

Este artigo é um relato de experiência de caso clínico de intervenção psicopedagógica por mediação lúdica com criança acometida de neurofibromatose tipo 1. Seu objetivo é relatar um excerto do caso, em que foi usada a intervenção psicopedagógica por mediação lúdica na estimulação e organização das funções psíquicas superiores do sujeito deste estudo, com foco especial em controle de comportamentos, planejamento das ações e função simbólica, a fim de promover seu desenvolvimento psíquico e ampliar sua capacidade de aprendizagem. O estudo usa metodologia qualitativa e parte do pressuposto vigotskiano da pesquisa como processo, que, ao mesmo tempo em que pesquisa, promove mudanças na realidade pesquisada. A metodologia usada nas intervenções foi a abordagem psicopedagógica por mediação lúdica de base conceitual na Teoria Histórico-Cultural do desenvolvimento psíquico humano. Como resultados, observamos o desenvolvimento do menino, que, ao final de dois meses de intervenções, estava mais organizado, controlando as suas ações dentro dos contextos propostos e iniciando o brincar de forma simbólica.
Molecular mechanisms highlighting the potential role of COVID-19 in the development of neurodegenerative diseases
Authors: Rahmani Behrouz , Ghashghayi Elham , Zendehdel Morteza , Baghbanzadeh Ali , Khodadadi Mina 
Published: June 2022

Abstract
Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In addition to the pulmonary manifestations, COVID-19 patients may present a wide range of neurological disorders as extrapulmonary presentations. In this view, several studies have recently documented the worsening of neurological symptoms within COVID-19 morbidity in patients previously diagnosed with neurodegenerative diseases (NDs). Moreover, several cases have also been reported in which the patients presented parkinsonian features after initial COVID-19 symptoms. These data raise a major concern about the possibility of communication between SARS-CoV-2 infection and the initiation and/or worsening of NDs. In this review, we have collected compelling evidence suggesting SARS-CoV-2, as an environmental factor, may be capable of developing NDs. In this respect, the possible links between SARS-CoV-2 infection and molecular pathways related to most NDs and the pathophysiological mechanisms of the NDs such as Alzheimer's disease, vascular dementia, frontotemporal dementia, Parkinson's disease, and amyotrophic lateral sclerosis will be explained.
COBERTURA VACINAL POR INFLUENZA VÍRUS NOS ESTADOS BRASILEIROS ANTES E APÓS O COVID-19
Authors: Gaujac Cristiano , Cunha Rafael Soares da , Amaral Regiane Cristina do 
Published: June 2022

Objetivo: comparar cobertura vacinal nos Estados brasileiros por Influenza Vírus no período de 2019 a 2020.
Metodologia: estudo observacional em que foram utilizados dados do DATASUS. Realizadas análises de séries temporais para a cobertura vacinal no período de 2000 a 2019. Foram ainda realizados teste t de Student comparando a cobertura vacinal contra o Influenza vírus nos anos de 2019 e 2020.
Resultados: foram verificadas as variações percentuais anuais (VPA) nos Estados brasileiros dos anos de 2000 a 2019, sendo verificado um percentual estacionário em relação a cobertura vacinal na maioria dos Estados. Em relação a cobertura vacinal contra o Influenza vírus, no período de 2019 e 2020 (campanhas vacinais), verifica-se diferença estatisticamente significativa para os grupos avaliados, exceto indígenas (p=0,97) e total (p=0,19), teste t de Student.
Conclusão: A pandemia do COVID 19 prejudicou grupos populacionais quanto a vacinação contra o Influenza vírus, como gestantes, crianças e puérperas.
FRONTEIRAS DIFUSAS E AMBÍGUAS DA COMUNICAÇÃO PÚBLICA
Authors: Rivelino de Amorim Roberto 
Published: June 2022

O objetivo do presente estudo teórico é refletir acerca das metamorfoses conceituais e das práticas da comunicação pública. A reflexão é no sentido da compreensão de como a comunicação se apropria do termo público para designar a produção de informação e conteúdo simbólico diferente do ofertado pela comunicação praticada pelos meios privados de comunicação de massa. Para isso, a abordagem e ancora na interdisciplinaridade para compreender o impacto transformador dos meios de comunicação de massa na vida social no mundo contemporâneo e sua intricada teia social que envolve as redes intersociais, o intercâmbio simbólico e as relações de poder. Num segundo gesto interpretativo, é desenhado um breve panorama das similaridades e diferenças da comunicação pública no Brasil.
Antropofagias horizontais: Silviano e Machado /Horizontal Anthtopophagies: Silviano and Machado
Authors: Walty Ivete Lara Camargos 
Published: June 2022

Resumo: Na pesquisa “Territorialidades literárias: projetos em diálogo”, tenho investigado a configuração de projetos de escrita de autores brasileiros em sua relação com os conceitos de literatura, nação, intelectual/escritor e sua atuação no espaço público, considerando sempre suas transformações no horizonte da relação estética, ética e política. Para isso, utilizo como operadores de leitura os conceitos de território, mapa, circuito, recursividade e movimentos antropofágicos. Considerando com Raffestin (1993, apud CANDIOTTO; SANTOS, 2008, p. 160) que a territorialidade pode ser definida como um conjunto de relações que se originam num sistema tridimensional sociedade-espaço-tempo, no presente trabalho estudo a relação entre as obras de Silviano Santiago e Machado de Assis, traçando esboços de seus projetos literários, tomados por si mesmos como territorialidades. Busco, então, investigar as metáforas que articulam a construção dos textos de Santiago em sua composição híbrida, traçando também sinalizadores de territorialidades outras, sobretudo aquelas que dizem respeito ao lugar da literatura no Brasil, seus agentes e objetos. Palavras-chave: metáforas; movimentos antropofágicos; projetos literários; territorialidades. Abstract: In the research “Literary territorialities: projects in dialogue”, I have investigated the configuration of writing projects by Brazilian authors regarding their relationship with the concepts of literature, nation, intellectual/writer and their performance in the public space, always considering their transformations in the horizon of the aesthetic, ethical and political relationship. For such, I have used the concepts of territory, map, circuit, recursion, and anthropophagic movements as reading operators. Based on Raffestin (1993, apud CANDIOTTO; SANTOS, 2008, p. 160) that territoriality can be defined as a set of relationships that originate in a three-dimensional system of society-space-time, in this work, I analyze the relationship between the works of Silviano Santiago and Machado de Assis, outlining their literary projects, given by themselves as territorialities. Thus, I aim at investigating the metaphors that articulate the construction of Santiago’s texts in their hybrid composition, as well as delineating signs of other territorialities, especially those that concern the place of literature in Brazil, its agents and objects. Keywords: metaphors; anthropophagic movements; literary projects; territorialities.
Sentiment Analysis Methods using Lexicon Approach
Authors: Kumar Surendra , Pathak Suryakant 
Published: June 2022

Opinions plays an important role in our daily life. We collect opinion from various sources such as companions and are influenced what we think about that particular in various types of decision making process. Assessment is a review concerning some article or topic etc. On the development and appearance of web 2.0, there are various websites has expanded complex such as twitter, linkedIn facebook etc. Due to this development, it increases the mumber of users and their content on these plateforms. It is an examination of user’s feelings for some specific topic or product. It is monstrously helpful in web-based data checking since it permits to acquire knowledge for popular assessment on some specific subjects. In this study we have handles a complete outline of Lexicon method and it implementation, updation time to time. Numerous as of late proposed improvements, various challenges faced in sentiment analysis and different Sentiment analysis applications are introduced and explored in this study.
MiR-132-3p inhibits proliferation, invasion and migration of colorectal cancer cells via down-regulating FOXP2 expression
Authors: Huang Rui , Xiang Guoan , Duan Xiaopeng , Wang Hanning , He Ke , Xiao Jinfeng 
Published: June 2022

Objective: colorectal cancer (CRC) is a common cancer with high mortality. This study aimed to investigate the role of microRNA (miR)-132-3p on proliferation, invasion and migration of CRC cells. Materials and Methods: qRT-PCR and Western blot analyses were used to determine the expression of miR-132-3p and forking box (FOX) protein 2 (FOXP2) in CRC cell line CACO-2. The expression of miR-132-3p and FOX was regulated using miR inhibitor and siRNA, and the viability and migration ability of the transfected cells were assessed. Cell cycle dependent kinase (CDK) 1, cyclin D1, matrix metalloproteinase (MMP)-2 and MMP-9 were detected using Western blots. The dual luciferase reporter gene assays were used to verify the targeting of miR-132-3p to FOXP2. Results: Compared with control cells, FOXP2 and miR-132-3p expressions were decreased or increased significantly (P<0.05), respectively in CACO-2 cells. Up-regulation of miR-132-3p effectively inhibited the proliferation, migration and invasion of CACO-2 cells, and suppressed the expression of FORX2, cyclin-dependent kinase 1 (CDK1), cyclin D1, MMP-2 and MMP-9. Luciferase reporter gene assays reveled that FOXP2 expression was negatively regulated by miR-132-3p. Knockdown of FOXP2 using siRNA significantly reduced the proliferation and migration of CACO-2 cells, down-regulated the expression FOXP2 as well as CDK1, cyclin D1, MMP-2 and MMP-9. Since FOXP2 is targeted by miR-132-3p, it is likely that miR-132-3p-mediated reduction of proliferation and migration of CACO-2 cells was achieved via reduced translation of FOXP2 mRNA. Conclusions: miR-132-3p inhibits the proliferation, migration and invasion of CRC cells. This is likely achieved via negative regulation of the targeted FOXP2 expression. This role may be further explored for therapeutic applications in CRC.
TOLERANSI DALAM KERAGAMAN: STUDI KASUS MASYARAKAT DESA GATAK, JAWA TENGAH
Authors: Lestari Puput Dwi 
Published: June 2022

Abstract: This article takes readers to the Village of Gatak in Central Java to see the tolerance of its multi-faith residents. The author interviewed the village figures, including the village head, religious leaders and the youth to understand the values that support a harmonious social life. She also observed activities that involve villagers regardless of their religions, including, the celebrations of religious holidays. The case of the Village of Gatak shows that tolerance develops with the support of some factors. For example, religious leaders hold and disseminate religious arguments for tolerance. Village leaders lead by examples in cultivating harmony within the community. Members of the community themselves must realize that they need others in life and that they need to respect others if they want peace. The lesson from the Village of Gatak affirms similar findings from other places in Indonesia on tolerance by previous researchers. Abstrak: Artikel ini mengajak pembaca mengunjungi Desa Gatak, di Jawa Tengah untuk melihat toleransi masyarakatnya yang multi-agama. Penulis mewawancarai tokoh-tokoh masyarakat, agama dan pemuda untuk menggali nilai-nilai yang melandasi kehidupan sosial yang rukun. Dia juga mengobservasi kegiatan-kegiatan yang melibatkan semua warga desa tanpa membeda-bedakan agamanya, terutama di perayaan hari besar nasional dan hari besar keagamaan. Berdasarkan penelitian lapangan di Desa Gatak, penulis menyimpulkan bahwa toleransi bisa dibangun jika sejumlah aspek mendukung. Misalnya, argumen keagamaan yang mendukung tolerasi dipegang oleh pemuka-pemuka agama dan disebarkan kepada masyarakat. Keteladanan dari tokoh-tokoh masyarakat yang selalu berupaya menciptakan kerukunan di antara warganya. Masyarakatnya sendiri harus menyadari bahwa mereka perlu orang lain dalam hidup dan perlu menghormati orang lain jika ingin kedamaian. Pelajaran dari Desa Gatak mengafirmasi sejumlah temuan dari wilayah lain oleh peneliti-peneliti lainnya.
SASTRA LISAN MENOLAK MATI: CERITA DAN PANTUN ISLAMI SEBAGAI MEDIA DAKWAH DI PUNGGUR, PONTIANAK
Authors: Saripaini Saripaini 
Published: June 2022

Abstract: Nowadays, television and gadget are so dominant in public and private places. The culture of watching TV and smart phones sidelines the tradition of listening to storytelling. But oral literature is not extinct with the advancement of communication and information technology. The case that this author found in Punggur Village, Pontianak, showed that oral literature, specifically, the religious genre, survived despite the bombardment of various entertainments broadcasted through electronic and digital media. Religious instructors in the village deliver moral messages to children learning al-Qur’an recitation through poems and stories. In fact, the method of storytelling has its own attraction in fostering children's interests to learn about religion. Abstrak: Dewasa ini, kehadiran televisi dan gawai begitu dominan di ruang publik dan privat. Budaya menonton TV dan ponsel pintar menggeser tradisi mendengarkan penuturan cerita secara lisan. Namun sastra lisan tidak punah diterjang perkembangan teknologi komunikasi dan informasi. Kasus yang penulis temukan di Desa Punggur, Pontianak, menunjukan bahwa sastra lisan, spesifiknya, yang bergenre agama, bertahan di tengah gempuran tontonan dan hiburan yang disiarkan melalui media elektronik dan digital. Di sana, guru-guru agama menyampaikan pesan moral kepada anak-anak yang belajar membaca al-Qur’an dengan menggunakan pantun dan cerita. Metode bercerita memiliki daya tarik tersendiri dalam menumbuhkan minat anak-anak untuk belajar agama.
TASAWUF DI WILAYAH PERKOTAAN: STUDI KASUS PENGAJIAN GURU YADI DI KOTA BANJARMASIN, KALIMANTAN SELATAN
Authors: Yanti Ridha Risda 
Published: June 2022

Abstract: In South Kalimantan, there are many tasawuf study groups, including the open and the secretive ones. This article discusses one example of secretive tasawuf study group located in Banjarmasin, the capital of South Kalimantan. The main focus is on the tasawuf teachings and practices of a man called Guru Yadi. To reflect on some sufi teachings, members of this study group practice some rituals unsual to other tasawuf study groups, namely, immersing their bodies in a pool filled with water and ice, laying down in a coffin to reflect on death, and sitting in an area where masquuitoes are plenty, training themselves of contentment. In addition to death reflection and contentment training, the main teachings of this study group are repentance, donation-making, and treating others nicely. Istigfar is a compulsory sacred recitation for the members, beside a variety of sholawat and Surah al-Ikhlas, before they start the above rituals. Based on my observation, this study group develops a falsafi-cum-akhlaki type of tasawuf. Abstrak: Di Kalimantan Selatan, terdapat banyak pengajian-pengajian tasawuf, baik yang terbuka maupun yang rahasia (sirr). Artikel ini mendiskusikan salah satu contoh pengajian tasawuf sirr yang berlokasi di Kota Banjarmasin. Pembahasan di sini meliputi ajaran dan praktek tasawuf asuhan seorang yang dikenal sebagai Guru Yadi. Untuk meresapi ajaran tasawuf, di pengajian ini ada sejumlah praktek yang tidak biasa, misalnya, menghilangkan rasa dengan berendam di kolam es, merenungi kematian dengan berbaring di peti mati, dan duduk tafakkur sambil melatih ikhlas di tempat yang banyak nyamuk. Selain mengingat mati dan melatih ikhlas, ajaran pokok lainnya dalam pengajian ini adalah bertaubat, bersedekah dan berbuat baik dengan sesama makhluk. Istigfar menjadi bacaan wajib bagi semua anggota jamaah pengajian ini, selain bermacam sholawat dan surah al-Ikhlas, sebelum mereka melaksanakan semua praktek di atas. Berdasarkan pengamatan saya, corak tasawuf yang dikembangkan di pengajian ini adalah falsafi dan akhlaqi.