bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of healthcare fragmentation and the survival of patients with colorectal cancer in Colombia
Authors: Patiño Andrés Felipe , Buitrago Giancarlo , Agudelo Nicolás Rozo , Espinel Laura Saldaña , Gamboa Oscar , Eslava-Schmalbach Javier , Bonilla Carlos , Cruz Óscar Guevara , Caycedo Rubén , Burgos Edgar Junca , Sánchez Ricardo 
Published: August 2022

Abstract
Background
Healthcare fragmentation is a phenomenon in which patients experience a discontinuity in healthcare. Patients with colorectal cancer are more likely to experience fragmented care because they require specialized treatment by multidisciplinary teams. The objective of this study was to identify the association between healthcare fragmentation and 3-year survival for patients with colorectal cancer in Colombia.
Methods
A retrospective cohort study was performed using administrative databases, with an electronic algorithm to identify patients with colorectal cancer based on codes. The patients were recruited between January 1, 2013 and December 31, 2016. The exposure variable was fragmentation, which was measured based on the number of different providers that treated a patient during the first year after diagnosis. Three-year mortality rates and incidence rate ratios (IRRs) were estimated for quartiles of fragmentation. A cut-off point was determined that divided the population between exposure to higher fragmentation versus lower fragmentation. Matching was performed using propensity scores to control for confounding, and the hazard ratio for exposure to higher fragmentation was calculated for the matched sample.
Results
A total of 5,036 patients with colorectal cancer was identified, 2,525 (49.88%) of whom were women. The mean number of network providers for the total sample was 5.71 (SD 1.98). The patients in the quartile with higher fragmentation had the highest mortality rate, 35.67 (95%CI; 33.63–38.06) per 100 patients. The comparison of higher and lower quartiles of fragmentation resulted in an IRR of 1.23 (95%CI; 1.04–1.45; p 0.02). Of the 5,036 patients, 422 (8.38%) were classified as the exposed cohort (higher fragmentation). The total matched sample consisted of 844 subjects, and an HR of 1.35 (95%CI; 1.14–1.61) was estimated.
Conclusions
Exposure to more highly fragmented healthcare networks decreases overall 3-year survival for patients with colorectal cancer in Colombia.
A Noval MPPT Design Based on the Seagull Օptimization Algοrithm for Phοtovοltaic Systems Operating Under Partial Shading
Authors: Chalh Abdelilah , chaibi Redouane , Hammoumi Aboubakr El , Motahhir Saad , Ghzizal Abdelaziz El 
Published: August 2022

Abstract
The use of a maximum power point (MPP) tracking (MPPT) controller is required for photovoltaic (PV) systems to extract maximum power from PV panels. However, under partial shading conditions, the PV cells/panels do not receive uniform insolation due to several power maxima appear on the PV array's P-V characteristic, a global MPP (GMPP) and two or more local MPPs (LMPPs). In this scenerio, conventional MPPT methods, including pertub and observe (P&Օ) and incremental conductance (INC), fail to differentiate between a GMPP and a LMPP, as they converge on the MPP that makes contact first, which in most cases is one of the LMPPs. This results in considerable energy loss. To address this issue, this paper introduces a new MPPT method based on the Seagull Optimization Algorithm (SOA) to operate PV systems at GMPP with high efficiency. The SOA is a new member of the bio-inspired algorithms. When compared to other evolutionary techniques, it uses fewer operators and modification parameters, which is advantageous when considering the rapid design process. In this paper, the SOA-based MPPT scheme is first proposed and then implemented for an 80 W PV system using the MATLAB/SIMULINK environment. The effectiveness of the SOA based MPPT method is verified by comparing its performance with P&Օ and PSO (particle swarm optimization) based MPPT methods under different shading scenarios. The results demonstrated that the SOA based MPPT method performs better in terms of tracking accuracy and efficiency.
Perioperative Outcomes in Patients with Systemic Sclerosis: Analysis of a Large Single- Center Case Series
Authors: Carr Zyad J. , Yan Luying , Yanez N. David , Schonberger Robert B. , Bohorquez Manuel , Hines Roberta L , Treggiari Miriam M. 
Published: August 2022

Abstract
Background
There are significant knowledge gaps regarding perioperative outcomes for patients with systemic sclerosis (SSc), a rare immune-mediated disease characterized by cutaneous and organ-based fibrosis. The primary aim of this study was to describe the incidence of various perioperative complications in a single-center population of SSc.
Methods
278 SSc patients with 605 unique surgical encounters were identified over a ten-year period (Jan 1, 2010, through Jan 1, 2020). Data collection included airway management, intraoperative adverse events (pulmonary aspiration, cardiac arrest, difficult airway designation), and 30-day postoperative complications (pneumonia, myocardial infarction, atrial fibrillation, congestive heart failure).
Results
Hypertension (57.9%), pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH) (52.5%), interstitial lung disease (ILD) (32.4%), and gastroesophageal reflux disease (82.4%) were common in our study population. Difficult direct laryngoscopy occurred in 10.9% of cases, but the first attempt success rate was high at 93.2%. Video laryngoscopy was used in 24.1% of cases. The most common intraoperative complications were hypotension and bradycardia within 15 minutes of induction (24.3% and 17.5%, respectively), and vasopressor use (34.0%). The in-hospital complication rate was 14.7% while the 30-day postoperative complication rate was 27.6%, with ileus > 3 days (5.6%) and postoperative pneumonia (POP) (5.5%) occurring most often. Microstomia was an independent predictor of difficult airway designation [Adjusted Odds Ratio (ORadj): 3.42, 95% Confidence Interval (CI) = 1.13, 10.31, p = 0.029]. ILD was not associated with 30-day POP (ORadj: 1.41, 95% CI = 0.54, 3.71, p = 0.482). A composite of PH/PAH was an independent predictor for 30-day POP (ORadj: 2.61, 95% CI = 1.08, 6.29, p = 0.033), 30-day CHF diagnosis (ORadj: 4.15, 95% CI = 1.33, 12.94, p = 0.014), and 30-day mortality (ORadj: 3.57, 95% CI = 1.24, 10.28, p = 0.018).
Conclusions
This study identified perioperative characteristics of patients with SSc. Current knowledge on perioperative outcomes in SSc in the surgical population is predominately based on reports of single case reports or small case series. Our findings suggest that intraoperative and airway complications are similar but postoperative complications are high when compared to known incidences in surgical populations. Secondly, this study demonstrates that composite PAH/PH but not ILD was a strong predictor of POP, CHF and 30-day mortality in this patient population.
Associations of phthalates with prostate cancer among the US population
Authors: Guo Tao , Meng Xiangyu , Liu Xuekui , Yan Shi , Zhang Xiaomin , Ren Shancheng , Wang Mengjing , Huang Yuhua 
Published: August 2022

Abstract
Human exposure to harmful phthalates has raised global health concerns. According to cellular and molecular investigations, phthalates and their metabolites promoted prostate cancer (PCa). Despite being prevalent cancer afflicting the global male population, the epidemiological association between phthalates and prostate cancer remains understudied. This work aims to investigate whether phthalate metabolites are related with prostate cancer. Moreover, we sought to understand whether their elevated concentrations are associated with increased serum concentrations of prostate-specific antigen (PSA) among non-prostate cancer interviewees. According to National Health and Nutrition Examination Survey (NHANES) data from 2003 to 2010, we screened eligible men aged 20 years or older, then crude and multivariate regression models were created to measure the relationship. The phthalates significantly related to PCa were analyzed based on variables associated with both prostate cancer status and prostate-specific antigen. A molar sum ∑Di-2-Ethylhexyl Phthalate (∑DEHP) was found simultaneously associated with increased risk of prostate cancer and increasing PSA. Within them, high molecular weight phthalate metabolites comprised mono-benzyl phthalate (MBzP) and 3 metabolites of DEHP. In summary, phthalates are potentially associated with impairing prostate status causing tumorigenesis in the US population. However, additional in-depth prospective studies in different ethnic groups are required to validate the causality between both.
Novel millimeter-wave Balun Using Embedded Magnetic Closed Loops
Authors: Zhou Yedi , Song Kaijun , Aidoo Michael Wilson , Fan Yong 
Published: August 2022

Abstract
A novel balun with magnetic closed loops has been developed. A conventional rectangular waveguide (RWG) directly mounts on a printed circuit board (PCB) that actualize the energy transition. Using a pair of centrosymmetric magnetic closed loop, the TE10 mode converts to TEM mode, and balanced ports of balun are obtained. Based on the structural characteristics investigation, the balun is fabricated and measured. The bandwidth is wider than 27% for insertion loss no more than 0.6 dB and return loss more than 15 dB. Between the two imbalanced ports, the magnitude imbalance is less than 0.4 dB, and the phase difference is less than 3°. Integration within the vertical transition makes the balun a promising candidate for minimization system.
Characterization and complete genome analysis of a novel Escherichia phage, vB_EcoM-RPN187
Authors: Imklin Napakhwan , Sripras Pattaraporn , Thanantong Narut , Lekcharoensuk Porntippa , Nasanit Rujikan 
Published: August 2022

Abstract
vB_EcoM-RPN187, a novel Escherichia phage, was isolated from drained water using Escherichia coli M187 as host. It has a prolate icosahedral head and a contractile tail. The phage produced clear plaques and was highly effective at 20–37°C. It was stable at 4–70°C and pH 3–10 for at least 1 h. The genetic analysis revealed that vB_EcoM-RPN187 has a 167,158 bp linear double-stranded DNA consisting of 265 protein-encoding genes and 10 tRNAs without undesirable genes. The overall nucleotide identity result suggested that the vB_EcoM-RPN187 may be classified as a new phage species in the genus Mosigvirus.
Quantitative evaluation of the sheared edge of woven glass epoxy laminate after mechanical punching
Authors: Choi Hyun Seok , Jeon Yong Jun , Choi Woo Chun , Kim Dong Earn 
Published: August 2022

Abstract
Fiber-reinforced composites have a wide range of industrial applications owing to their light weight, high modulus, and good specific strength. Trimming using a mechanical punching tool is the fastest way to post process fiber-reinforced composites. However, quantitative analyses of the defects and process parameters are required to analyze the damage mechanisms and achieve high-quality cut surfaces. In this study, we quantitively investigated the defects on the sheared edge of woven glass epoxy laminates subjected to mechanical punching and explored the correlations between these defects and key process parameters, including punch-die clearance, weave alignment angle, and laminate thickness. The results demonstrate the necessity of considering glass fiber burr length and the dimensions of the cracked area simultaneously to evaluate the quality of the sheared surface. This study provides qualitative data on the interfacial damage mechanisms that occur during mechanical punching, which will help to tailor the process parameters of mechanical punching for fiber-reinforced polymers to obtain smooth cut surfaces.
Microwave Ablation and Synchronous Transarterial Chemoembolization Combined with PD-1 Inhibitor in Patients with Hepatocellular Carcinoma Following Tyrosine Kinase Inhibitor Intolerance
Authors: Shi Qin , Zhou Xin , Yang Minjie , Zhang Wen , Zhang Zihan , Yu Jiaze , Ma Jingqin , Liu Qingxin , Qu Xudong , Luo Jianjun , Liu Lingxiao , Yan Zhiping 
Published: August 2022

Abstract
Purpose: To determine the safety and efficacy of microwave ablation (MWA) and synchronous transarterial chemoembolization (TACE) combined with or without PD-1 inhibitor in patients with hepatocellular carcinoma (HCC) following tyrosine kinase inhibitor (TKI) intolerance.Materials and Methods: This study retrospectively enrolled TKI-intolerant HCC patients who underwent MWA-TACE combined with PD-1 inhibitor (MTP) or MWA-TACE (MT) from January 2019 to June 2021. MWA and TACE were performed simultaneously, and PD-1 inhibitor was administered intravenously at a dose of 200 mg once every three weeks after MWA-TACE. Adverse events (AEs) related to treatment were recorded during the follow-up. Progression-free survival (PFS) and overall survival (OS) were compared between the two groups.Results: A total of 87 patients were included and classified into the MTP group (n =42) and MT group (n=45). Complications related to MWA-TACE in the MTP group were similar to that in the MT group (21.4% vs. 24.4%, P = 0.738). Moreover, 35 (83.3%) patients had eighty-four AEs related to PD-1 inhibitor in the MTP group, and 8 (19.0%) patients developed grade 3. Patients who underwent MWA-TACE combined with PD-1 inhibitor had better PFS (median, 10.0 vs. 4.7 months, P < 0.001) and OS (median, 17.0 vs. 8.5 months, P < 0.001) than those who underwent MWA-TACE alone. Treatment method and Child-Pugh class were independent prognostic factors for survival in the univariate and multivariate analysis.Conclusion: MWA and synchronous TACE combined with PD-1 inhibitor might be a favorable treatment option in TKI-intolerant HCC patients.
High expression of ELAVL1 predicts poor prognosis of Esophageal Carcinoma
Authors: Si Fuchun , Du Haiyang , Si Gao , Si Jiqing 
Published: August 2022

Abstract
N6-methyladenosine (m6A) is the most prevalent RNA epigenetic regulation in eukaryotic cells. However, understanding of m6A in Esophageal carcinoma (ESCA) is very limited. We designed this study to investigate the role of m6A in ESCA. Expression pattern of m6A regulatory genes were extracted from gene array of 21cases of ESCA and public datasets to investigate the clinical relevance of m6A regulatory genes in ESCA. Next, we used public datasets to evaluate the relationship between m6A regulatory genes change and survival rates by the Kaplan-Meier analysis method. KEGG Pathway Enrichment Analysis and Gene Set Enrichment Analysis to identify the signaling pathways. The differences of immune cell subtypes were evaluated based on CIBERSORT algorithm. High expression level of ELAVL1 was significantly associated with worse overall survival (OS) of ESCA (P < 0.05). The levels of ELAVL1 were positively associated with macrophages M0(R=0.34, P=0.025), T follicular helper cells (R=0.44, P=0.0035), while Plasma cells (R=0.59, P=0.000041), and CD8 T cells (R=0.44, P=0.0038) exhibited an opposite result. ELAVL was in positive association with PSMC3IP. Our findings highlight the function and prognostic value of ELAVL1 in ESCA and extend the understanding of the importance of RNA epigenetics in cancer biology.
DDCM ： A Decentralized Density Clustering and Its Results Gathering Approach
Authors: Zou Lida 
Published: August 2022

Abstract
Distributed clustering is an important way to solve large-scale data mining problem. At present, there still exist some problems for distributed clustering, such as performance bottleneck of master node and network congestion caused by global broadcast. In the paper, we propose a decentralized clustering method based on density clustering and content-addressable network technique. It could generate a cluster just depending on the surrounding several nodes, which realizes load balancing and has excellent scalability. An optimization way of gathering clustering results in different application scenarios is addressed as well. Our extensive experiments show that the proposed approach performs 3 times better than benchmark algorithm in time efficiency and has a stable expansion ratio at about 0.6 for large-scale data.
Contribution of Stables Isotopes to the Study of the Groundwater Recharge in the Southern Foothills of the Saharan Atlas: The case of Tolga Region, North Eastern Algeria
Authors: Zouaoui Siham , Menani Mohamed Redha , Gaagai Aissam , Bouabid Abdennasser , Bencedira Selma , Zekker Ivar , Aouissi Hani Amir 
Published: August 2022

Abstract
Tolga groundwater is one of Biskra's most important water supplies for both drinking and agriculture. The purpose of this study is to assess the hydrochemical and isotope (2H and 18O) signature of water in the Tolga area. To evaluate the hydrogeology of groundwater in the Tolga region, a chemical, piezometric, and isotopic research was employed. The results of the Piper diagram revealed that there is just one major hydrochemical facies in the research region, which corresponds to Ca–Mg–Cl–SO4. The piezometry of limestone sheets shows that as one goes westward, the turns become less substantial, with turns about 20 meters and a piezometric level of 140 m. For the first time, the local meteoric water line (LMWL) was drawn for Complexe Teminal (CT) and Continental Intercalaire (CI) on Tolga groundwater. The Tolga area LMWL refers to the equation δ2H= 7,18 δ18O + 4.17 with R2 about 0.85. CI and CT measurement locations indicate deuterium excess values ranging from 8.35 to 12.57. Indeed, the majority of values were more than 10‰ (mean of 10.36 ± 2.01‰). Furthermore, waters from Eocene have an isotopic composition of -7.57 ± 0.68‰ in δ18O and − 49.04 ± 4.69‰ In δ2H. The results of the sample characterisation analysis show that the majority of the groundwater samples analysed are of the Ca-Mg-SO4 water type. In addition, the intense exploitation aquifer water and the region's arid climatic conditions resulted in a large decrease in the piezometric limestone level. Finely, the signature of 2H and 18O data indicate that water comes from local precipitation and recent water, and groundwater recharge is influenced by quick infiltration.
Climate, environment and the fortunes of Buddhism during the Tibetan Empire 618-842 CE
Authors: Zou Yi , Cheng Jianquan , Cresswell Mark P. , Lageard Jonathan Guido Andre 
Published: August 2022

Abstract
The official adoption of Buddhism by the Tibetan state in the mid-8th Century (761-762 CE) was relatively late compared to its permeation from northern India to elsewhere in south and east Asia, due to the country’s geographical isolation. Whilst reasons for its adoption remain uncertain, it is thought that the religion provided a strong unifying influence permitting both the consolidation and subsequent expansion of the Tibetan Empire. Early historical records suggest that the religion was prohibited in 739-741 CE and 841-842 CE, the latter coinciding with the fall of the Tibetan Empire. This research presents an examination of Tibetan and Chinese historical records and fine-resolution palaeoclimatic reconstructions to demonstrate that the ‘oscillating fate’ of Buddhism during the Tibetan Empire (618-842 CE), was inextricably linked to regional climate change and to a series of natural disasters. Extreme meteorological events have significant present-day impacts on the geographically vulnerable Tibetan Plateau, and we propose that long-term climatic deterioration between mid-770s to the late 830s CE was likely to have been the most significant factor underpinning environmental deterioration and the eventual collapse of the rural economy, which undermined the Buddhist state in the 9th century CE and lead to the prohibition of the religion in both Tibet, and by the neighbouring Tang Dynasty.
GBP Serves as a Novel Prognostic Biomarker in Human Glioblastoma
Authors: A Naer , Lyu Pengfei , Cheng Shaohua , Yu Yue , Chen Meiyan , Liu Yunhong , Cao Xuchen 
Published: August 2022

Abstract
The most frequent primary intracranial tumors are gliomas. The malignancy of various tumor grades varies, and tumor heterogeneity is common. Despite the variety of therapeutic options available, most glioma patients still have a dismal prognosis, causing considerable pain to glioma sufferers throughout the world. The research of glioma's intrinsic disease processes and the development of new treatment targets are critical. The family's big GTPases, which are engaged in a variety of activities including cell inflammation, proliferation, and apoptosis, play a significant role in cancer. The goal of this work is to determine the mechanism of action of the GBPs family in glioblastoma and to provide a novel approach to glioma mechanistic research and therapy. We analyzed the mRNA expression, protein level expression, prognostic value, genetic changes, and immunological infiltration of the GBPs family in glioma patient tissues employing GEPIA2, Human Protein Atlas (HPA), cBio Portal, and TIMER databases. The effects of the essential gene GBP2 on tumor cell proliferation and invasion were also confirmed. Differential expression of the GBPs family was detected in GBM, with differential expression of GBP1 and GBP2 correlated with GBM patient prognosis. Besides this, we discovered that the GBPs family and associated genes are engaged in a variety of activities, including the cellular response to interferon−γ, GTP binding, endoplasmic reticulum architecture, and protein complex oligomerization. GBPs family gene expression is linked to tumor immune cell infiltration, and genetic variations in the gene can affect immune cell infiltration in GBM patients. GBP2 gene expression enhances tumor cell proliferation and invasion, according to further experimental confirmation. We investigated the role of GBPs in GBM and discovered that GBP1/2 are possible biomarkers for predicting prognosis and tumor immune infiltration in GBM patients, with GBP2 expression potentially contributing to the impact of tumor invasion and proliferative capability.