bluuebunny/crossref_metadata_2025_split huggingface dataset:
Culinary Center in Dalegan Gresik, East Java with a Wave Metaphor Architecture Approach
Authors: Sholicha Ni’matus , Widjajanti Wiwik Widyo , Poedjioetami Esty 
Published: January 2022

Tourism sector has potential of development as it belongs to one of regional revenue sources for Gresik Regency. One of tourism sectors that has great potential is culinary tourism. To Gresik Regency, improving tourism is possible to do because total visits of culinary tourism get increasing from year to year. Unfortunately, a specific culinary site which can accommodate typical food of Gresik has not been available yet. Therefore, the researcher planned and designed Culinary Centre in Dalegan Gresik, East Java under the theme of metaphoric architecture. To collect the research data, several methods were employed such as field study, literature study, and descriptive analysis. The macro concept of recreational is implemented by adjusting the title in the tourism site through the micro concept of dynamic land order having relaxed elements. The micro concept of shape accommodates wavy metaphor of sea water. Thus, this design is expected to be used as the basis for Gresik development so that it becomes a tourism object which can provide food-based recreational service and entertainment to all tourists.
İnsanız Hava Aracı (Drone) ile Erozyon Alanlarının Tespiti: Trakya Yarımadası Örneği
Authors: SARI Hüseyin 
Published: January 2022

Bu çalışma, Trakya Yarımadası’nda tespit edilen erozyon bölgelerinin alan ve hacimlerinin Coğrafi Bilgi Sistemleri (CBS) kullanılarak hesaplanması amacı ile gerçekleştirilmiştir. Uzaktan algılama ile yapılan ölçümler hem zaman kazanımı hem de fazla işgücünün önüne geçmektedir. Ayrıca drone ile çekim yapılabilecek araziler için satın alınabilecek uydu görüntülerinden daha az maliyetli olmaktadır. Bu amaçla, bölgede doğal karakteristikleri farklılık gösteren 13 erozyon alanı incelenmiş ve insansız hava aracı (drone) ile görüntüler elde edilmiştir. Çalışmada İHA verilerinin kalibrasyonu amacıyla sınırları belli olan ve doğaya zarar vermeyen beyaz boya ile sınırları belirlenmiş ve çeşitli yüksekliklerden bu alanların tüm ölçümleri (uzunluklar, açılar vb.) yapılmıştır. Sınırları belirlenen alanlar daha sonra İHA görüntüleri alınarak CBS yazılımları ve grafik programı “Autodesk Inventor” ile çeşitli proseslerden geçirilerek hacim hesaplaması yapılmıştır. Görüntülerde farklılık olmaması için uygun hava koşulları beklenmiş ve birleştirilecek olan İHA görüntüleri benzer hava şartlarında elde edilmiştir. Farklı hava koşullarında alınan görüntülerin birleştirilmesinde ışık, gölge gibi faktörlerin hesaplamalarda herhangi bir sapmaya neden olmaması ve görsel olarak farklılık oluşturmaması için özen gösterilmiştir. Toplam 13 adet erozyon alanlarından görüntüler alınmış ve çalışmada koordinat sistemi olarak WGS 1984 (World Geodetic System 1984) kullanılmıştır.
Bu görüntüler birleştirilerek bu alanların ortomozaik görüntüleri oluşturulmuştur. Görüntülerdeki bölgelerin alan ve hacimlerinin yanı sıra kalibrasyonları da yapılmıştır. Yapılan çalışmada, kalibrasyon için küçük bir alanın kullanılması alansal hesaplamada doğruluk oranını %90’ın üzerine çıkarırken hacim ölçümlerinde ise bu oran uçuş yüksekliğine göre %60 – 78 arasında bulunmuştur.
Yaklaşık 100 m2 alanda yapılan kalibrasyon çalışmasında 100 metre yükseklikten çekilen görüntüde 12 fotoğraf, 10 metre yükseklikten çekilen görüntüde ise 103 fotoğraf kullanılmıştır. Buna göre, yerden 10 metre yükseklikten çekilen görüntüde hacimsel doğruluk oranı %78,57 bulunmuştur.
Putative Prevention of XML Injection Against Myocardial Ischemia Is Mediated by PKC and PLA2 Proteins
Authors: Jin Ling , Yin Qianqian , Mao Yiqing , Gao Yuanxu , Han Qing , Mei Ruisi , Xue Lixiang , Tan Huanran , Li Hui 
Published: January 2022

Background: Xinmailong (XML) injection is a CFDA-approved traditional Chinese medicine with clinical value for heart failure treatment. The present investigation was aimed to evaluate the potential protective roles of this injection on myocardial ischemia and the underlying molecular mechanism.Methods: In our study, we selected two models of myocardial ischemia rats. Rats were randomly divided into six groups, with saline or XML administrated 4 days before ischemia model establishment. ECG of different time intervals and biochemical parameters of end point were measured. The potential mechanisms of the protective role of XML were explored using system pharmacology and molecular biology approaches.Results: Myocardial ischemia rats demonstrated abnormal ECG and serum levels of cTnT. Pretreatment with XML significantly attenuated these damages, especially the medium doses. GO and KEGG analysis revealed that the 90 putative target genes were associated with pathways of fatty acid absorption/metabolism, inflammation, RAAS, and vascular smooth muscle. Further network pharmacology method identified five main chemical ingredients and potential targets of XML injection for myocardial ischemia. Mechanically, the beneficial effect of XML injection was mediated by the reactive oxygen species (ROS) inhibition and inflammation attenuation via regulating the expression levels of targets of PKC and PLA2.Conclusion: These findings indicate that XML exerts protective effects against myocardial injury, with attenuated ROS production, apoptosis, and inflammation. Therefore, we speculate that XML may be an alternative supplementary therapeutic agent for myocardial ischemia prevention.
Functionalized Multi-Walled Carbon Nanotube–Based Aptasensors for Diclofenac Detection
Authors: Zou Yi , Griveau Sophie , Ringuedé Armelle , Bedioui Fethi , Richard Cyrille , Slim Cyrine 
Published: January 2022

Driven by the increasing concern about the risk of diclofenac (DCF) residues as water pollutants in the aqueous environment and the growing need for its trace determination, a simple but sensitive electrochemical aptasensor for the trace detection of DCF was developed. To construct the aptasensor, the amine-terminated DCF aptamer was covalently immobilized on the surface of the carboxylic acid–functionalized multi-walled carbon nanotube (f-MWCNT)–modified glassy carbon electrode (GCE) through EDC/NHS chemistry. The f-MWCNTs provide a reliable matrix for aptamer immobilization with high grafting density, while the aptamer serves as a biorecognition probe for DCF. The obtained aptasensor was incubated with DCF solutions at different concentrations and was then investigated by electrochemical impedance spectroscopy (EIS). It displays two linear ranges of concentration for DCF detection, from 250 fM to 1pM and from 1 pM to 500 nM with an extremely low detection limit of 162 fM. Also, the developed biosensor shows great reproducibility, acceptable stability, and reliable selectivity. Therefore, it offers a simple but effective aptasensor construction strategy for trace detection of DCF and is anticipated to show great potential for environmental applications.
Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome
Authors: Shilts Meghan H. , Rosas-Salazar Christian , Strickland Britton A. , Kimura Kyle S. , Asad Mohammad , Sehanobish Esha , Freeman Michael H. , Wessinger Bronson C. , Gupta Veerain , Brown Hunter M. , Boone Helen H. , Patel Viraj , Barbi Mali , Bottalico Danielle , O’Neill Meaghan , Akbar Nadeem , Rajagopala Seesandra V. , Mallal Simon , Phillips Elizabeth , Turner Justin H. , Jerschow Elina , Das Suman R. 
Published: January 2022

BackgroundThe upper respiratory tract (URT) is the portal of entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and SARS-CoV-2 likely interacts with the URT microbiome. However, understanding of the associations between the URT microbiome and the severity of coronavirus disease 2019 (COVID-19) is still limited.ObjectiveOur primary objective was to identify URT microbiome signature/s that consistently changed over a spectrum of COVID-19 severity.MethodsUsing data from 103 adult participants from two cities in the United States, we compared the bacterial load and the URT microbiome between five groups: 20 asymptomatic SARS-CoV-2-negative participants, 27 participants with mild COVID-19, 28 participants with moderate COVID-19, 15 hospitalized patients with severe COVID-19, and 13 hospitalized patients in the ICU with very severe COVID-19.ResultsURT bacterial load, bacterial richness, and within-group microbiome composition dissimilarity consistently increased as COVID-19 severity increased, while the relative abundance of an amplicon sequence variant (ASV), Corynebacterium_unclassified.ASV0002, consistently decreased as COVID-19 severity increased.ConclusionsWe observed that the URT microbiome composition significantly changed as COVID-19 severity increased. The URT microbiome could potentially predict which patients may be more likely to progress to severe disease or be modified to decrease severity. However, further research in additional longitudinal cohorts is needed to better understand how the microbiome affects COVID-19 severity.
Exercise-Induced Cardiac Fatigue in Recreational Ultramarathon Runners at Moderate Altitude: Insights From Myocardial Deformation Analysis
Authors: Wolff Sebastián , Picco José M. , Díaz-González Leonel , Valenzuela Pedro L. , Gonzalez-Dávila Emanuel , Santos-Lozano Alejandro , Matile Pablo , Wolff David , Boraita Araceli , Lucia Alejandro 
Published: January 2022

BackgroundControversy exists on the actual occurrence of exercise-induced cardiac fatigue (EICF) with ultraendurance exercise, as well as on whether factors such as age or training status might predispose to this condition. The present study aimed to assess the occurrence of EICF among recreational ultramarathon runners, as well as to determine potential predictive factors.MethodsNineteen male recreational runners (42 ± 12yrs) participated in a 55-km trial race at moderate altitude (1,800–2,500 m). Participants were evaluated before and after the race using Doppler echocardiography and myocardial deformation analysis. EICF was determined as a reduction &gt;5% of either left ventricular global longitudinal strain (LVGLS) or right ventricular free wall strain (RVFWS). Demographical (age, body mass index), training (training experience, volume and intensity), competition (finishing time, relative intensity) and biochemical variables (blood lactate, creatine kinase [CK] and CK-MB) were assessed as predictors of EICF.ResultsA significant reduction in LVGLS (20.1 ± 2.1% at baseline vs. 18.8 ± 2.4% at post-race, p = 0.026), but not in RVFWS (27.4 ± 7.0 vs. 24.6 ± 5.3%, p = 0.187), was observed after the race. EICF was present in 47 and 71% of the participants attending to the decrease in LVGLS and RVFWS, respectively. No associations were found between any of the analyzed variables and EICF except for age, which was associated with the magnitude of decrement of RVFWS (r = 0.58, p = 0.030).ConclusionsUltramarathon running at moderate altitude seems to induce EICF in a considerable proportion of recreational athletes.
Importance of Acute Anterior Angulation in Double Aortic Arch Needing Attention at Primary Surgery
Authors: Beeman Arun , Ramaswamy Madhavan , Srinivasan Yadav , Rudrappa Siddartha , Christov Georgi , Marek Jan , Derrick Graham , Muthialu Nagarajan 
Published: January 2022

BackgroundVascular rings are rare congenital abnormalities of the aortic arch. There are many embryological variants including a double aortic arch. In symptomatic children, division of ring and release of airway structures may be sufficient. Persistence of symptoms can be related to an anterior angle formed between the two arches. The aim of this study is to evaluate the clinical efficacy in improving symptoms and on changing this angle at the primary surgery.MethodsAll children who had surgery for double aortic arch between 2005 and 2020, were studied. Relevant factors were analyzed for persistent symptoms including anatomical substrates and surgical details.ResultsA total of 87 out of 224 children had surgery for a double aortic arch. At presentation, airway symptoms (n = 74/87) were more common than esophageal symptoms (n = 27/87). Early onset symptoms within 1 year were seen in 49 children. In addition to division of one arch, surgical steps also included realigning the anterior left arch, thereby eliminating the acute angle in 36 children (after 2014). After surgery, symptom relief within 12 months following surgery was seen in 64% of children (56 out of 87) but in 27 out of 36 children (75%) with additional surgical modification, as against 29 out of 51 (57%) in those with division of the arch. Symptoms persisted beyond 1 year needing reintervention in eight children.ConclusionAnterior arch angulation plays an important role in double aortic arch by causing a “nutcracker” phenomenon. Repair in double aortic arch should consider this aspect and include modification of surgical steps by realigning the corresponding aortic arch branches and an anterior pexy in selected cases.
Postload Plasma Glucose but Not Fasting Plasma Glucose Had a Greater Predictive Value for Cardiovascular Disease in a Large Prospective Cohort Study in Southwest China
Authors: Wang Yingying , Yu Lisha , Wang Yiying , Zhou Jie , Wu Yanli , Liu Tao , Wang Na , Fu Chaowei 
Published: January 2022

BackgroundUncertainty remains regarding the relevance of glycemia, though below the threshold for diabetes, for the risk of cardiovascular disease (CVD) among the Southwest Chinese. We aimed to examine the associations of the first-onset CVD with fasting plasma glucose (FPG) and 2-h postload glucose (2h-PG) in Southwest China.MethodsThe current study examined data from the Guizhou Population Health Cohort Study (GPHCS) of 9,280 participants aged 18 to 95 years recruited from 12 areas since 2010 in Guizhou Province, Southwest China. Participants were followed-up until December, 2020. Primary outcomes were the first onset of a composite of or one of major CVD events, including ischaemic stroke, haemorrhagic stroke and myocardial infarction. FPG, 2h-PG, other metabolic factors and some demographic factors were collected at baseline. Cox proportional hazards models were used to estimate the risk of CVD associated with FPG and 2h-PG. Sensitive analysis and stratified analysis were conducted among participants across different modifiable risk factors and demographic featuresResultsDuring a median of 6.58 years of follow-up, of 7,593 participants with available data for analysis, 174 experienced at least one CVD events, 158 developed stroke (including 126 ischemic stroke and 39 Ischemic stroke events), and 24 developed myocardial infarction. The risk of major CVD events was significantly increased with elevated 2h-PG but not FPG. Compared with participants in the lowest tertile of 2h-PG, those in the highest tertile had a 1.87-fold (95%CI: 1.26–2.77) increased risk for overall CVD, a 1.82-fold (95%CI: 1.20–2.75) increased risk for overall Stroke, and a 1.82-fold (95%CI: 1.20–2.75) increased risk for ischemic stroke, respectively, after adjustment for age, sex, smoking, ethnic group, education level, systolic blood pressure (SBP), triglycerides (TG), body mass index (BMI) and waist circumference (WC). However, there was no relation of glycemia of haemorrhagic stroke or myocardial infarction (P &gt; 0.05). The effect sizes in the associations of CVD with 2h-PG become enhanced among those within normal range of glycemia, SBP, TG, BMI, as well as those without hypertension, dyslipidemia.and obesity.Conclusions2h-PG, in contrast to FPG, is a significant indicator in predication of CVD in Southwest Chinese. Elevated 2h-PG, though below the below the threshold for diabetes, remains independently increased the risk of CVD.
Prevalence and Risk Factors of QTc Prolongation During Pregnancy
Authors: Luo Chaodi , Duan Zhenzhen , Jiang Yi , Liu Peng , Yan Yang , Han Dan 
Published: January 2022

BackgroundProlonged QT intervals have been observed in pregnant women, which predispose them to a higher risk of potentially lethal ventricular arrhythmias. This study was designed to evaluate the prevalence of QTc prolongation in Chinese hospitalized parturient women with single and twin pregnancies, and to explore potential risk factors associated with QTc prolongation.MethodsThis retrospective study included 1,218 patients from a large Chinese population between January 2014 and October 2020. Data from parturient women with single and twin pregnancies without pre-pregnancy cardiac diseases were collected. QTc was corrected by the Fridericia formula [QTc = QT/RR(1/3)], and QTc ≥ 460 ms for females was defined as prolonged QTc, QTc ≥ 500 ms was defined as severely prolonged QTc. The prevalence and common risk factors of QTc prolongation during pregnancy were analyzed in this cohort. Uni- and multivariable logistic regression analysis were performed to identify clinical parameters associated with QTc prolongation in this population.ResultsThe prevalence of QTc prolongation was 48.19% among this population, 10.56% in single pregnancy, 89.44% in twin pregnancies. The prevalence of severely prolonged QTc was 23.48% among the total cohort, 0.49% in single pregnancy, and 46.47% in twin pregnancies. The mean QTc interval was significantly longer in twin pregnancies than in single pregnancy (498.65 ± 38.24 vs. 424.96 ± 27.67 ms, P &lt; 0.001). Systolic blood pressure, diastolic blood pressure, total cholesterol, serum uric acid, gestational hypertension and twin pregnancies were associated with QTc prolongation in parturient women.ConclusionThis is the first study to assess the prevalence and risk factors of QTc prolongation between single and twin pregnancies. QTc prolongation is more prevalent, and QTc intervals are significantly longer in twin pregnancies as compared to single pregnancy.
Diagnostic Value of Serum Concentration of Galectin-3 in Patients With Heart Failure With Preserved Ejection Fraction
Authors: Jiang Jing , Yang Baojun , Sun Ying , Jin Jing , Zhao Zhiying , Chen Songming 
Published: January 2022

BackgroundAlthough the predictive value of galectin-3 for heart failure with preserved ejection fraction has been demonstrated, the diagnostic value remains unclear. The present study was performed to address this issue.HypothesisGalectin-3 has diagnostic value for heart failure with preserved ejection fraction.MethodsThis is a diagnostic experiment. We conducted an observational study of 223 patients with combined symptoms of heart failure and diseases that can lead to heart failure with preserved ejection fraction. Patients were grouped into the heart failure group and control group in accordance with the 2016 European Society of Cardiology heart failure guidelines for heart failure with preserved ejection fraction. Baseline information and serum galectin-3 concentration were assessed within 24 h after admission.ResultsSerum galectin-3 concentration was significantly higher in the heart failure group compared with the control group. Binary logistic regression analysis showed that higher galectin-3 concentration was associated with the occurrence of heart failure with preserved ejection fraction. The area under the curve of galectin-3 was 0.763, indicating that galectin-3 has moderate diagnostic value for heart failure with preserved ejection fraction. Galectin-3 &gt;15.974 ng/mL identified heart failure with preserved ejection fraction with 76.0% sensitivity and 71.9% specificity.ConclusionsThere was a correlation between galectin-3 and heart failure with preserved ejection fraction, and galectin-3 was an independent predictor of heart failure with preserved ejection fraction. The diagnostic value of galectin-3 for heart failure with preserved ejection fraction was moderate (AUC: 0.763, 95% CI: 0.696–0.821, P &lt; 0.01, and the sensitivity is 76.0% while the specificity is 71.9% at the threshold 15.974 ng/mL) and was higher than that of interventricular septal thickness or E/A ratio.
Acoustic Predictors of Active Fluid Expulsion From a Hydrothermal Vent Field, Offshore Taupō Volcanic Zone, New Zealand
Authors: Spain Erica , Lamarche Geoffroy , Lucieer Vanessa , Watson Sally J. , Ladroit Yoann , Heffron Erin , Pallentin Arne , Whittaker Joanne M. 
Published: January 2022

Understanding fluid expulsion is key to estimating gas exchange volumes between the seafloor, ocean, and atmosphere; for locating key ecosystems; and geohazard modelling. Locating active seafloor fluid expulsion typically requires acoustic backscatter data. Areas of very-high seafloor backscatter, or “hardgrounds,” are often used as first-pass indicators of potential fluid expulsion. However, varying and inconsistent spatial relationships between active fluid expulsion and hardgrounds means a direct link remains unclear. Here, we investigate the links between water-column acoustic flares to seafloor backscatter and bathymetric metrics generated from two calibrated multibeam echosounders. Our site, the Calypso hydrothermal vent field (HVF) in the Bay of Plenty, Aotearoa/New Zealand, has an extensive catalogue of vents and seeps in &lt;250 m water depth. We demonstrate a method to quantitatively link active fluid expulsion (flares) with seafloor characteristics. This allows us to develop predictive spatial models of active fluid expulsion. We explore whether data from a low (30 kHz), high (200 kHz), or combined frequency model increases predictive accuracy of expulsion locations. This research investigates the role of hardgrounds or surrounding sediment cover on the accuracy of predictive models. Our models link active fluid expulsion to specific seafloor characteristics. A combined model using both the 30 and 200 kHz mosaics produced the best results (predictive accuracy: 0.75; Kappa: 0.65). This model performed better than the same model using individual frequency mosaics as input. Model results reveal active fluid expulsion is not typically associated with the extensive, embedded hardgrounds of the Calypso HVF, with minimal fluid expulsion. Unconsolidated sediment around the perimeter of and between hardgrounds were more active fluid expulsion sites. Fluids exploit permeable pathways up to the seafloor, modifying and refashioning the seafloor. Once a conduit self-seals, fluid will migrate to a more permeable pathway, thus reducing a one-to-one link between activity and hardgrounds. Being able to remotely predict active and inactive regions of fluid expulsion will prove a useful tool in rapidly identifying seeps in legacy datasets, as well as textural metrics that will aid in locating nascent, senescent, or extinct seeps when a survey is underway.