bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Heterozygous Mutation in MFF Associated with a Mild Mitochondrial Phenotype
Authors: Murata Daisuke , Grunseich Christopher , Iijima Miho , Chan David , Corse Andrea , Hoke Ahmet , Schindler Alice , Sesaki Hiromi , Roda Ricardo H. 
Published: October 2022

Background: The number of mutations in nuclear encoded genes causing mitochondrial disease is ever increasing. Identification of these mutations is particularly important in the diagnosis of neuromuscular disorders as their presentation may mimic other acquired disorders.We present a novel heterozygous variant in mitochondrial fission factor (MFF) which mimics myasthenia gravis. Objective: To determine if the MFF c.937G>A, p.E313K variant causes a mild mitochondrial phenotype. Methods: We used whole exome sequencing (WES) to identify a novel heterozygous variant in MFF in a patient with ptosis, fatigue and muscle weakness. Using patient derived fibroblasts, we performed assays to evaluate mitochondrial and peroxisome dynamics. Results: We show that fibroblasts derived from this patient are defective in mitochondrial fission, despite normal recruitment of Drp1 to the mitochondria. Conclusions: The MFF c.937G>A, p.E313K variant leads to a mild mitochondrial phenotype and is associated with defective mitochondrial fission in patient-derived fibroblasts.
Projection domain processing for low-dose CT reconstruction based on subspace identification
Authors: Ren Junru , Liang Ningning , Yu Xiaohuan , Wang Yizhong , Cai Ailong , Li Lei , Yan Bin 
Published: October 2022

Purpose: Low-dose computed tomography (LDCT) has promising potential for dose reduction in medical applications, while suffering from low image quality caused by noise. Therefore, it is in urgent need for developing new algorithms to obtain high-quality images for LDCT. Methods: This study tries to exploit the sparse and low-rank properties of images and proposes a new algorithm based on subspace identification. The collection of transmission data is sparsely represented by singular value decomposition and the eigen-images are then denoised by block-matching frames. Then, the projection is regularized by the correlation information under the frame of prior image compressed sensing (PICCS). With the application of a typical analytical algorithm on the processed projection, the target images are obtained. Both numerical simulations and real data verifications are carried out to test the proposed algorithm. The numerical simulations data is obtained based on real clinical scanning three-dimensional data and the real data is obtained by scanning experimental head phantom. Results: In simulation experiment, using new algorithm boots the means of PSNR and SSIM by 1 dB and 0.05, respectively, compared with BM3D under the Gaussian noise with variance 0.04. Meanwhile, on the real data, the proposed algorithm exhibits superiority over compared algorithms in terms of noise suppression, detail preservation and computational overhead. The means of PSNR and SSIM are improved by 1.84 dB and 0.1, respectively, compared with BM3D under the Gaussian noise with variance 0.04. Conclusion: This study demonstrates the feasibility and advantages of a new algorithm based on subspace identification for LDCT. It exploits the similarity among three-dimensional data to improve the image quality in a concise way and shows a promising potential on future clinical diagnosis.
Prediction of response to neoadjuvant chemotherapy in advanced gastric cancer: A radiomics nomogram analysis based on CT images and clinicopathological features
Authors: Tan Xiaoying , Yang Xiao , Hu Shudong , Ge Yuxi , Wu Qiong , Wang Jun , Sun Zongqiong 
Published: October 2022

PURPOSE: To investigate the feasibility of predicting the early response to neoadjuvant chemotherapy (NAC) in advanced gastric cancer (AGC) based on CT radiomics nomogram before treatment. MATERIALS AND METHODS: The clinicopathological data and pre-treatment portal venous phase CT images of 180 consecutive AGC patients who received 3 cycles of NAC are retrospectively analyzed. They are randomly divided into training set ( n = 120) and validation set ( n = 60) and are categorized into effective group ( n = 83) and ineffective group ( n = 97) according to RECIST 1.1. Clinicopathological features are compared between two groups using Chi-Squared test. CT radiomic features of region of interest (ROI) for gastric tumors are extracted, filtered and minimized to select optimal features and develop radiomics model to predict the response to NAC using Pyradiomics software. Furthermore, a nomogram model is constructed with the radiomic and clinicopathological features via logistic regression analysis. The receiver operating characteristic (ROC) curve analysis is used to evaluate model performance. Additionally, the calibration curve is used to test the agreement between prediction probability of the nomogram and actual clinical findings, and the decision curve analysis (DCA) is performed to assess the clinical usage of the nomogram model. RESULTS: Four optimal radiomic features are selected to construct the radiomics model with the areas under ROC curve (AUC) of 0.754 and 0.743, sensitivity of 0.732 and 0.750, specificity of 0.729 and 0.708 in the training set and validation set, respectively. The nomogram model combining the radiomic feature with 2 clinicopathological features (Lauren type and clinical stage) results in AUCs of 0.841 and 0.838, sensitivity of 0.847 and 0.804, specificity of 0.771 and 0.794 in the training set and validation set, respectively. The calibration curve generates a concordance index of 0.912 indicating good agreement of the prediction results between the nomogram model and the actual clinical observation results. DCA shows that patients can receive higher net benefits within the threshold probability range from 0 to 1.0 in the nomogram model than in the radiomics model. CONCLUSION: CT radiomics nomogram is a potential useful tool to assist predicting the early response to NAC for AGC patients before treatment.
Persepsi Berhubungan dengan Stigma Masyarakat pada Penderita Tuberkulosis Paru
Authors: Sajodin Sajodin , Ekasari Virna Damayanthy , Syabariyah Sitti 
Published: October 2022

Penderita tuberculosis mengalami perlakuan yang tidak menyenangkan baik dari lingkup masyarakat, lingkungan disekitar rumah, maupun lingkungan kerja seperti adanya sebuah penolakan, dikucilkan, diskriminasi, bahkan hingga pemecatan dari tempat kerja. Stigma negative ini disebabkan karena adanya pengetahuan masyarakat mengenai penyakit tuberculosis yang masih terbatas, sehingga masyarakat minimnya sebuah informasi sehingga masyarakat memiliki persepsi yang salah terhadap penderita tuberculosis. Tujuan dari penelitian ini merupakan untuk mengetahui adanya hubungan antara persepsi dengan stigma masyarakat terhadap penderita tuberkulosis paru di wilayah kerja Puskesmas Parongpong Kecamatan Parongpong Kabupaten Bandung Barat. Metode penelitian ini menggunakan desain penelitian deskriptif korelasi dengan pendekatan cross sctional terhadap 100 sampel dengan menggunakan sebar kuesioner secara online. Sampel pada penelitian ini adalah masyarakat di wilayah kerja Puskesmas Parongpong. Pengambilan sampel dilakukan secara purposiv sampling. Analisa data menggunakan distribusi frekuensi dan untuk mengetahui hubungan menggunakan uji statistik Perason Product Moment. Dari hasil penelitian ini menunjukan tidak ada hubungan yang signifikan (p value = 0,183 > 0,05; r= 0,134) antara persepsi dengan stigma masyarakat terhadap penderita tuberkulosis paru
Edukasi melalui Buklet Sehat untuk Meningkatkan Perilaku Hidup Bersih dan Sehat (PHBS) pada Masyarakat Pesisir Kota Pasuruan
Authors: Kusuma Erik , Nastiti Ayu Dewi , Puspitasari R.A. Helda , Handayani Dwining 
Published: October 2022

PHBS yang rendah pada masyarakat pesisir memberikan dampak negatif pada masyarakat berupa munculnya masalah kesehatan baik pada bayi dan anak, orang dewasa maupun lansia. Penelitian ini bertujuan untuk mengetahui pengaruh edukasi melalui buklet sehat untuk meningkatkan perilaku bersih dan sehat (PHBS) pada masyarakat pesisir Kota Pasuruan. Desain penelitian ini adalah pre eksperimental one group pre-post test design. Teknik pengambilan sampel menggunakan purposive sampling dengan jumlah sampel sebanyak 92 rumah tangga. Instrumen pengumpulan data menggunakan kuesioner. Kuesioner terdiri atas data demografi responden, kuesioner pengetahuan, sikap, dan tindakan. Data yang diperoleh dianalisis dengan uji Wilcoxon dengan tingkat signifikansi 0.05. Hasil penelitian ini menunjukkan bahwa pengetahuan, sikap dan perilaku masyarakat pesisir meningkat setelah diberikan edukasi melalui buklet sehat (p=0.000) sehingga disimpulkan ada pengaruh pemberian edukasi melalui buklet sehat dalam meningkatkan Perilaku Hidup Bersih dan Sehat (PHBS) pada masyarakat pesisir Kota Pasuruan. Dengan menanamkan nilai-nilai karakter perilaku hidup bersih dan sehat, maka lambat laun perilaku hidup bersih dan sehat tersebut akan tumbuh dalam diri seseorang dan direfleksikan dalam perilaku sehari-hari. Partisipasi anggota keluarga dalam PHBS akan meningkatkan pemahaman masyarakat tentang hidup bersih dan sehat sehingga dapat berkontribusi dalam meningkatkan kesehatan masyarakat.
ΟΝ THE MOHYLIAN SUBTEXT IN HRYHORII SKOVORODA’S DIALOGUE «ARCHISTRATIGUS MICHAEL'S FIGHT WITH SATAN»
Authors: Bartolini Maria Grazia 
Published: October 2022

The paper explores Hryhorii Skovoroda’s dialogue “Archistratigus Michael's Fight with Satan” (“Bran Arkhystratyha Mykhaila so Satanoiu”, 1783), which contains several quotations from two authors — Teofan Prokopovych and Varlaam Liashchevskyi – who belonged to Skovoroda’s Alma Mater, the Kyiv Mohyla Academy. Being a unique occurrence in Skovoroda’s writings, these quotations from contemporary authors have been analyzed as an instance of a peculiar “Mohylian subtext” that sheds light on the relationship between the Ukrainian philosopher and his Alma Mater. In “Bran Arkhystratyha”, the angelic ranks battling against demonic forces sing a song taken from Liashchevskyi’s tragicomedy “The Chased Church” (“Honymaia tserkov”) and from Prokopovych’s 1709 epinikion in honor of tsar Peter’s victory near Poltava. While Prokopovych’s verses have been slightly changed (Antichrist replaces ‘apostate’ — ‘otstupnyk’) to reflect the major theme of “Bran Arkhystratyha” — the fight against Satan — the presence of two fragments from Liashchevskyi's tragicomedy in the text is even more important, as “Bran Arkhystratyha” is the only available source for reconstructing the textual content of this tragicomedy, of which we do not possess any extant copies. Of particular interest are also the paratextual materials attached to the quotations from Liashchevskyi and Prokopovych. All three citations are accompanied by an explanatory note stating: 1) the author to whom the citation belongs; 2) the authors’ affiliation to the Kyiv-Mohyla Academy; 3) information about the fire that destroyed the library of the Kyiv-Mohyla Academy on February 29, 1780. This choice testifies to a specific urge on Skovoroda’s part to honor Alma Mater and its representatives three years after the fire that threatened its book collection and cultural legacy. In this personal tribute, the notion of memory acquires a specific meaning for, in the case of Liashchevskyi, “Bran Arkhystratyha” preserves a text that would not otherwise have been transmitted. Thus, the ‘victory’ glorified in the dialogue becomes first and foremost a victory against oblivion, through the projection of the Word into the realm of eternity.
HRYHORII SKOVORODA AND DISCOURSE OF UKRAINIAN MODERNISM
Authors: Krysa Bohdana 
Published: October 2022

The aim of the paper is to explore the line of Ukrainian Modernity which is expressed in the writings of Hryhorii Skovoroda by combining the Christian concept of human life and the experience of Antiquity, perceived through the prism of Christianity. In this context, the motive of spiritual renewal is directly conditioned by the understanding of the interaction of God’s Word with the human one, which is manifested in the persistent work of revealing the biblical meaning and creating a new form for its preservation and transmission. In this way, the timeless nature of the human ideal and its function in distinguishing the temporal forms of the new and the old, the real and the false, is affirmed. It is noticed that Skovoroda's concepts and images agree with the theories of modernism and modern identity of the 20th and early 21st centuries.
Against the background of the elongated, even irritating discourse of Ukrainian Modernism caused by external and internal transformations of national existence, Skovoroda’s markers prove that spiritual, moral, and expressive priorities may be conflicting but not deny each other. This is mostly true for language and correlation of religion and metaphysics. According to Skovoroda, the art of the form serves as a shell, amulet, and translator of the divine meaning revealing life-giving depths. In this sense, the whimsical clothing of the word draws attention to the process of cognition, gives an opportunity to see the inner behind the external. In this regard, the continuity between the Baroque and Romanticism determines primarily their common spiritual space, due to the whirlpool of the same sources.
It is concluded that Skovoroda’s creative figure always becomes a landmark for Ukrainian Modernism, because due to him even modernity is understood not only as a certain era or ideology but as the inner state and inner world of an author. This state can coexist with the patriarchal way of life and with the phenomena of real or conditional progress. In this sense, the thesis of the unfinished project of Ukrainian modernism must be understood from the perspective of eternal travel and distant horizons, which may not always equally reveal but do equally contain sources of Antiquity and Christianity.
IMAGES OF CHRIST AND THE VIRGIN MARY IN THE POETRY OF HRYHORII SKOVORODA AND WIRA WOWK
Authors: Hryhorchuk Yuliia 
Published: October 2022

The paper analyzes the images of Jesus Christ and the Mother of God in the poetry by Hryhorii Skovoroda and Wira Wowk. Until now, this topic has not been the object of scholarly research although the creativity of writers has many common features: aphoristic style, philosophical mood, and biblical figurative elements. The purpose of the paper is to characterize the specifics of interpreting the images of Christ and the Mother of God in the authors’ poetry. The analysis is based on the collections “The Garden of Divine Songs” by H. Skovoroda and “The Rosary for Christ”, “The Rosary for the Mother of God” by Wira Wowk.
Peculiar in the reception of the figure of Christ in the poetry of both authors is its outer featurelessness and deep semantic content. H. Skovoroda used the concepts of ʻlifeʼ, ʻjoyʼ, ʻpure heartʼ and the biblical symbols of fire, stone, word, and grain; Wira Wowk preferred the symbols of word, light, heart, and ear of corn. Each author is characterized by the original interpretation of the biblical image of the Savior. He is embodied in the figures of a guest, an astronomer, a doctor hurt for human faults (poetry by H. Skovoroda) and a doctor, a heavenly gardener, a helmsman on Cheremosh (poetry by Wira Wowk).
The image of the Virgin in H. Skovoroda’s work is less pronounced than the image of Jesus and is revealed only in three poems, while Wira Wowk dedicated three separate collections to the Virgin Mary. There are different symbolic hypostases of the Mother of God in the poems by H. Skovoroda, which have been singled out. Wira Wowkʼs interpretation of this image is characterized by such features as iconographic specification, biblical dynamics of unfolding, and symbolic content (images of the Winged Mother of God, the Mother Princess, Lilia, Oranta). The image of Mother Mary is common to both authors (Mary, Mother of Jesus — in Skovoroda’s poems and Mother of humanity, the world, and Ukraine — in Wira Wowk’s ones).
Special attention has been paid to the biblical prototext in the poetic works by H. Skovoroda and Wira Wowk, important in the interpretation of the figures of Christ and the Mother of God, as well as to the moral and axiological depth of these images and their conceptual significance.
Faktor yang Berhubungan Dengan Upaya Peningkatan Kualitas Hidup Penderita Diabetes Melitus Selama Masa Adaptasi Kebiasaan Baru di Wilayah Kerja Puskesmas Andalas
Authors: Yulia Yulia , Rizyana Nurul Prihastita , Rahma Gusni 
Published: October 2022

Diabetes Melitus (DM) merupakan salah satu penyakit penyerta utama setelah hipertensi dari kejadian kasus positif dan kasus meninggal covid-19. Berdasarkan Data Satuan Tugas Covid-19, dari total kasus terkonfirmasi positif covid-19 , penderita yang memiliki riwayat penyakit penyerta Diabetes diperoleh 34,5%. Dari total kasus meninggal akibat Covid-19 diperoleh 7,7% adalah penderita Diabetes Melitus. Penelitian ini bertujuan untuk menganalisisfaktor yang berhubungan dengan upaya peningkatan kualitas hidup penderita DM salaam masa adaptasi kebiasaan baru di Wilayah Kerja Puskesmas Andalas.Desain penelitian ini adalah cross sectional. Variabel dependen adalah kualitas hidup penderita Diabetes sedangkan variabel independennya adalah tingkat kecemasan, aktivitas fisik, info kesehatan, dukungan keluarga dan dukungan tenaga kesehatan. Penelitian ini menggunakan Google Form yang disebarkan kepada pasien yang berkunjung ke Puskesmas Andalas dengan metode pusposive sampling diperoleh sampel sebanyak 43 orang selama satu minggu. Berdasarkan hasil penelitian ini sebagian besar penderita DM selama masa adaptasi kebiasaan baru memiliki kualitas hidup sedang 39,53%.Terdapat hubungan yang bermakna status kecemasan (p=0,006), aktivitas fisik (p=0,024), dukungan keluarga (p=0,003)dan dukungan tenaga kesehatan (p=0,038)dengan kualitas hidup penderita DM selama masa adaptasi kebiasaan baru di Wilayah Kerja Puskesmas Andalas.Selama adaptasi kebiasaan baru diharapkan kepada penderita DM untuk tetap melakukan aktifitas fisik secara rutin. Keluarga dan tenaga kesehatan selalu memberikan dukungan kepada penderita DM selama masa adaptasi kebiasaan baru.
Aktivitas Antimikroba Ekstrak Daun Mulberry (Morus Rubra L) Terhadap Penghambatan Pertumbuhan Jamur Candida Albicans-In Vitro
Authors: Hidayatunnikmah Nina , Latifah Anik , Cahya Rosyida Desta Ayu , Safitri Sella Dwi 
Published: October 2022

Candida albicans merupakan penyebab utama infeksi vagina. Aktifitas antimikroba dan senyawa berry menunjukkan bahwa kandungan anthocyanin dapat melindungi dari bakteri patogen manusia. Pertumbuhan buah mulberry di Indonesia tumbuh secara liar dan pemanfaatnya sedikit oleh masyarakat Indonesia karena kurangnya ketidaktahuan masyarakat terhadap manfaat farmakologis yang di miliki oleh tumbuhan mulberry. Kandungan yang terdapat didalam daun Mulberry adalah alkaloid, flavonoid, dan polifenol. Jenis penelitian yang akan dilakukan ini menggunakan desain penelitian eksperimental laboratories dengan pendekatan Post-Test Only Control Group Design. Penelitian ini dilakukan di Laboratorium Biologi Farmasi Universitas PGRI Adi Buana Surabaya dan Laboratorium Profesor Nidhom Foundation Surabaya. Daun mulberry yang akan diekstrak diambil di tanaman yang ada di Fakultas Sains dan Kesehatan Universitas PGRI Adi Buana Surabaya. Jumlah sampel adalah 8 seri pengenceran ekstrak mulberry (15%, 30%, 45%, 60%, 75%, 80%, 95%, 100%) dalam 4 cawan petri. Tahap Persiapan dialkukan dengan melakunan pembuatan stok bakteri pada media agar serta pembuatan ekstrak daun Mulberry. Cawan petri yang berisi Nutrient Agar dituang dengan suspense Candida albicans dan selanjutnya diberikan ekstrak mulberry dengan 8 seri pengenceran dan diinkubasi selama 24 jam. Hasil menunjukan terdapat zona hambat pada konsentrasi ekstrak mulberry 80%, 95%, 100% pada keempat cawan petri. Kesimpulan terdapat pengaruh ektrak mulberry pada aktivitas antimikroba candida albicans pada konsentrasi ekstrak 80%,95%, dan 100%.
EDUKASI PERILAKU HIDUP BESIH DAN SEHAT (PHBS) DAN PENGELOMPOKKAN SAMPAH DI SD ISLAM INSAN UNGGUL KOTA KENDARI, PROVINSI SULAWESI TENGGARA
Authors: Kasmawati Henny , Suryani Suryani , Fitrawan La Ode Muhammad , Hikmah Nurull , Sida Nurramadhani A. , Ruslin Ruslin , Aswani Aswani 
Published: October 2022

In order to accelerate recovery after the Covid-19 pandemic, especially in Kendari, South East Sulawesi, it is necessary to understand and be aware of the importance of maintaining health which starts with a healthy clean-living behaviour (PHBS) which starts from an early understanding of doing PHBS in elementary schools (SD). Important indicators that become critical in this activity are how to wash hands well and group organic and inorganic waste. This activity is also a manifestation of the President's vision for 2020-2024 through the Ministry of Health to improve public health. This community service aims to increase public understanding and awareness, especially students of SD Islam Insan Unggul Kendari about the importance of carrying out healthy clean-living behaviour (PHBS). The method used is education by showing PHBS videos and socialization followed by interactive quizzes. This activity was easily well received by the participants because it used a learning-by-play approach so that the participants were easier to remember and apply in everyday life.
Scalable Fabrication of Metallic Conductive Fibers from Rheological Tunable Semi-Liquid Metals
Authors: Tian Shujun , Peng Hao , Liu Huaizhi , Zhou Jiancheng , Zhang Jiuyang 
Published: October 2022

Conductive polymer fibers/wires (CPFs) are important materials in modern technologies due to their unique one-dimension geometry, electrical conductivity, and flexibility. However, the advanced applications of current CPFs are limited by their low electrical conductivities (<500 S/m) and poor interfacial interactions between conductive fillers (e.g., graphite) and polymers. Therefore, in current electrical applications, metal wires/foils like copper and aluminum are the most frequently utilized conductive fibers/wires instead of the inferior conductive CPFs. This work successfully addresses the heavy phase segregation between polymers and conductive inorganic materials to obtain semiliquid metal polymer fibers (SLMPFs) which exhibit an ultrahigh electrical conductivity (over 10
6
S/m), remarkable thermal processability, and considerable mechanical performance (Young’s modulus: ~300 MPa). Semiliquid metal (gallium-tin alloy) with tunable viscosities is the key to achieve the excellent miscibility between metals and polymers. Both the rheological results and numerical simulations demonstrate the critical viscosity matching for the successful preparation of the fibers. More importantly, the fibers are adapted with classic polymer melt-processing like melt injection, which indicates the scalable production of the highly conductive fibers. The SLMPFs are highly promising substitutes for metal wires/fibers in modern electrical applications such as electricity transmission, data communication, and underwater works.