bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding volunteering intensity in older volunteers
Authors: Le Giang Huong , Aartsen Marja 
Published: October 2022

AbstractAlthough volunteering is considered a good strategy for successful ageing, not many older adults are engaged in voluntary work and those who are do so mainly sporadically. This study focuses on time invested in volunteering rather than on doing voluntary work or not, as is often done in studies so far. By combining the theory of resources for volunteering with a functional and structural approach to volunteering, this cross-sectional study seeks to shed light on a wide range of factors associated with the intensity of volunteering. The study is based on a sample of 1,599 volunteers aged 50 and older participating in the Norwegian study on Life Course, Ageing and Generation Study (NorLAG). The survey includes, among others, detailed information about demographics and time invested in voluntary work and questions about attitudes, motivations, structural and other potential barriers to volunteering. Multivariate linear regression analyses indicate that a religious attitude is associated with elevated hours spent on voluntary work, while co-habitation is associated with a decreased engagement in voluntary work. In addition, people who are motivated to volunteer because they find it interesting and because volunteering allows them to use their competence spend more time volunteering. Human capital, i.e. education, income and subjective health, are not associated with the number of hours invested in voluntary work. The likelihood of contributing more volunteering hours of older men is 17.5 per cent higher than that of older women. We found no indication of a relation between work status, functional limitations, urbanisation or ethnicity and voluntary work engagement. Policies aiming to increase time investment of volunteers should strive for an optimal fit between the nature of the voluntary work and the interests and skills of the volunteers. In designing interventions to stimulate higher engagement in voluntary work, one should further promote strategies for flexible time commitment.
Residing in communal senior housing: situating the ageing self within debates of the universal welfare state
Authors: Vasara Paula 
Published: October 2022

AbstractCurrently, Nordic welfare societies are at a crossroads. Ongoing demographic changes – such as ageing, accompanied by challenges in financing adequate services for all – have highlighted the need to consider the roles of citizens and the state in a novel way. Balancing rights and responsibilities has always been at the core of universalism, even though, traditionally, trust in the welfare state's ability to fulfil its basic function of providing necessary services for all has been strong. However, of late, subtle signs of change have become more visible, and in practice, older people's housing and care provisions have been marked by the state's withdrawal. By employing narrative analysis, this study explores, through the experiences of residents in age-related intermediate housing, how older people make use of, negotiate and embed the arguments being made in societal debates on the rights and responsibilities of ageing citizens. The accounts showcase the ways in which these narrators are able to accommodate the sometimes contradictory elements in their narration, accept the demand for increased responsibility for their later-life arrangements and construct plausible portraits of themselves as morally responsible citizens. These subtle negotiations and the acceptance of personal responsibility indicate a change in their perceptions of and expectations from the citizens and the state. Whilst the findings comprise stories of good outcomes, they also question the legitimacy of the current welfare system's universalism and its ability to guide the way to achieve equally good outcomes for all in the future.
Cooperative control strategy of wheel-legged robot based on attitude balance
Authors: Shen Yaojie , Chen Guangrong , Li Zhaoyang , Wei Ningze , Lu Huafeng , Meng Qingyu , Guo Sheng 
Published: October 2022

AbstractTo integrate the uneven terrain adaptivity of legged robots and the fast capacity of wheeled robots on even terrains, a four wheel-legged robot is addressed and the cooperative control strategy of wheels and legs based on attitude balance is investigated. Firstly, the kinematics of wheel-legged robot is analyzed, which contains the legged and wheeled motion modal. Secondly, the cooperative control strategy of wheel-legged robot based on attitude balance is proposed. The attitude is calculated by using the quaternion method and complementary filtering, and the attitude stability control of the wheel-legged robot is studied. The trajectory planning of leg motion including walk and trot gait is implemented, and the differential control of wheeled motion is deduced. And then, the cooperative motion control of wheels and legs is achieved by keeping the attitude balance of robot body. Finally, a small prototype is set up to validate the feasibility and effectiveness of proposed method. The experimental results show that the established wheel-legged robot can do walk, trot, and wheel-leg compound motion to overcome many complex terrains and environments.
Design of an E-sectoral horn based on PRGW technology for 5G applications
Authors: El-Din M. S. H. Salah , Shams Shoukry I. , Allam A. M. M. A. , Gaafar Abdelhamid , Elhennawy Hadia M. , Sree Mohamed Fathy Abo 
Published: October 2022

AbstractE-plane sectoral horn antenna based on printed ridge gap waveguide (PRGW) technology is designed for 5G applications. It is implemented on the top plate of the PRGW structure to avoid the losses and dispersion associated with conventional feeding mechanisms. The quasi-transverse electromagneticPRGW-based antenna is excited through a planar microstrip transition. First, the single horn antenna element is introduced with the microstrip feeding section. It shows an impedance bandwidth of fractional bandwidth 26% from 45.7 to 55.4 GHz with the realized gain of 12.7 dBi and radiation efficiency of 90%. In order to maximize the realized gain, a four-element linear horn array is introduced. The same impedance bandwidth is maintained with the array having a gain of 18.6 dBi from 45.7 to 55.4 GHz. The overall antenna array performance in the entire operating frequency range is stable with a radiation efficiency around 85%. Three matching sections are implemented to achieve better impedance matching. One is used to match the horn with the feeding aperture via the PRGW line. Another section is designed to match microstrip transition with PRGW ridge. Finally, two-stage quarter wavelength transformers are required to match the power divider with the array feeding network. A prototype of single-element horn antenna was fabricated to verify the concept of the design. Simulated and measured results show that the proposed antenna can operate in the frequency band of 45–55 GHz with good agreement of radiation performance. Moreover, the proposed designs are implemented and simulated using two microwave simulation tools (CST and HFSS) to verify the radiation performance, which exhibits good agreement. The design of an E-sectoral horn antenna and its array with high gain based on PRGW is demonstrated for the first time which is considered a novel issue. It can be integrated with other passive and active elements in communication systems. Thus, it can be a valuable component in 5G communication due to its high gain, compact size and ultra-wide band.
“You feel a bit unsexy sometimes”: The psychosocial impact of a spinal cord injury on sexual function and sexual satisfaction
Authors: Barrett Olivia E. C. , Mattacola Emily , Finlay Katherine A. 
Published: October 2022

AbstractStudy designA qualitative, semi-structured interview design.ObjectivesThis study aimed to identify, from the perspective of people living with a Spinal Cord Injury (SCI), the primary psychosocial barriers and facilitators that impact on their sexual function and sexual satisfaction post-injury.SettingCommunity-dwelling sample of people with SCI in England, United KingdomMethodsSemi-structured interviews with twenty people with SCI (15 males; 5 females) were conducted using an 8-item interview schedule. Inductive thematic analysis was undertaken of verbatim transcripts coded using Braun and Clarke’s (2021) six phases of thematic analysis.ResultsSix inductive themes were generated, collectively describing the psychosocial barriers and facilitators impacting on sexual function and satisfaction post-SCI: (1) Internalising societal views and stigmatisation; (2) Diminished sexual confidence; (3) Navigating communication; (4) Managing relationship dynamics; (5) Lack of sexual support provision; and (6) Intervention development recommendations.ConclusionSexual function and satisfaction are highly challenging areas of rehabilitation for males and females living with SCI. Increased efforts are needed to educate others in society to overcome the negative stereotypical attitudes obstructing acceptance of sex despite disability. Countering sexual stigmatisation for people with SCI would facilitate growth in sexual confidence. Techniques to enhance interpersonal sexual communication and involve the partner/spouse in regaining mutual sexual satisfaction are foundational. The current study highlighted key outpatient-based recommendations for intervention development, clarifying primary targets for future SCI-focused sexual therapeutic work.
Koller and the dawn of cancer cytogenetics
Authors: Norbury Chris J. 
Published: October 2022

SummaryShortly before the DNA era began, PC Koller described lagging chromosomes and chromosome numerical abnormalities in human carcinomas. While present-day cancer geneticists would question some of Koller’s conclusions, this study ultimately contributed to the realisation that chromosomal instability is a widespread feature of solid tumours.
Advancing clinical and translational research in germ cell tumours (GCT): recommendations from the Malignant Germ Cell International Consortium
Authors: Fonseca Adriana , Lobo João , Hazard Florette K. , Gell Joanna , Nicholls Peter K. , Weiss Robert S. , Klosterkemper Lindsay , Volchenboum Samuel L. , Nicholson James C. , Frazier A. Lindsay , Amatruda James F. , Bagrodia Aditya , Lockley Michelle , Murray Matthew J. 
Published: October 2022

AbstractGerm cell tumours (GCTs) are a heterogeneous group of rare neoplasms that present in different anatomical sites and across a wide spectrum of patient ages from birth through to adulthood. Once these strata are applied, cohort numbers become modest, hindering inferences regarding management and therapeutic advances. Moreover, patients with GCTs are treated by different medical professionals including paediatric oncologists, neuro-oncologists, medical oncologists, neurosurgeons, gynaecological oncologists, surgeons, and urologists. Silos of care have thus formed, further hampering knowledge dissemination between specialists. Dedicated biobank specimen collection is therefore critical to foster continuous growth in our understanding of similarities and differences by age, gender, and site, particularly for rare cancers such as GCTs. Here, the Malignant Germ Cell International Consortium provides a framework to create a sustainable, global research infrastructure that facilitates acquisition of tissue and liquid biopsies together with matched clinical data sets that reflect the diversity of GCTs. Such an effort would create an invaluable repository of clinical and biological data which can underpin international collaborations that span professional boundaries, translate into clinical practice, and ultimately impact patient outcomes.
Early radiologic signal of responsiveness to immune checkpoint blockade in microsatellite-stable/mismatch repair-proficient metastatic colorectal cancer
Authors: Meltzer Sebastian , Negård Anne , Bakke Kine M. , Hamre Hanne M. , Kersten Christian , Hofsli Eva , Guren Marianne G. , Sorbye Halfdan , Flatmark Kjersti , Ree Anne Hansen 
Published: October 2022

Abstract
Background
Immune checkpoint blockade (ICB) results in radiologic tumour response dynamics that differ from chemotherapy efficacy measures and require an early signal of clinical utility.

Methods
Previously untreated, unresectable microsatellite-stable (MSS)/mismatch repair-proficient (pMMR) colorectal cancer (CRC) patients were randomly assigned to the oxaliplatin-based Nordic FLOX regimen (control arm) or repeat sequential two FLOX cycles and two ICB cycles (experimental arm). The radiologic response was assessed every 8 weeks. In this post hoc analysis, we explored early target lesion (TL) dynamics as indicator of ICB responsiveness. Progression-free survival (PFS) was the primary endpoint.

Results
Using a landmark analysis approach, we categorised experimental-arm patients into ≥10% (N = 19) or <10% (N = 16) TL reduction at the first post-baseline response assessment. Median PFS for the groups was 16.0 (95% confidence interval (CI), 12.3–19.7) and 3.9 months (95% CI, 2.3–5.5), respectively, superior and inferior (both P < 0.01) to the median PFS of 9.8 months (95% CI, 4.9–14.7) for control arm patients (N = 31).

Conclusions
Radiologic TL reduction of ≥10% at the first post-baseline response assessment identified patients with ICB-responsive metastatic MSS/pMMR-CRC. This pragmatic measure may be used to monitor patients in investigational ICB schedules, enabling early treatment adaptation for unresponsive cases.

Trial registration
ClinicalTrials.gov number, NCT03388190 (02/01/2018).
Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage
Authors: Lv Qianying , Han Xinli , Ni Jiajia , Ma Qianqian , Dai Rufeng , Liu Jiaojiao , Liu Jialu , Zhai Yihui , Shen Qian , Sun Li , Liu Haimei , Rao Jia , Xu Hong 
Published: October 2022

AbstractProteinuria, an indication of kidney disease, is caused by the malfunction of podocytes, which play a key role in maintaining glomerular filtration. Angiopoietin-like 3 (ANGPTL3) has been documented to have a cell-autonomous involvement in podocytes, and deletion of Angptl3 in podocytes reduced proteinuria in adriamycin-induced nephropathy. Here, we developed a monoclonal antibody (mAb) against ANGPTL3 to investigate its effects on podocyte injury in an ADR nephropathy mouse model and puromycin (PAN) induced podocyte damage in vitro. The mAb against the human ANGPTL3-FLD sequence (5E5F6) inhibited the binding of ANGPTL3-FLD to integrin β3. Treatment with the 5E5F6 mAb in ADR nephropathy mice mitigated proteinuria and led to a significant decline in podocyte apoptosis, reactive oxygen species (ROS) generation and mitochondrial fragmentation. In PAN-induced podocyte damage in vitro, the 5E5F6 mAb blocked the ANPGPLT3-mediated activation of integrin αvβ3 and Rac1, which regulated the mitochondrial homeostasis. Altogether, anti-ANGPLT3-FLD mAb attenuates proteinuria and podocyte lesions in ADR mice models, as well as PAN-induced podocyte damage, in part through regulating mitochondrial functions. Our study provides a therapeutic approach for targeting ANGPTL3 in proteinuric kidney disease.
Real-time holographic lensless micro-endoscopy through flexible fibers via fiber bundle distal holography
Authors: Badt Noam , Katz Ori 
Published: October 2022

AbstractFiber-based micro-endoscopes are a critically important tool for minimally-invasive deep-tissue imaging. However, current micro-endoscopes cannot perform three-dimensional imaging through dynamically-bent fibers without the use of bulky optical elements such as lenses and scanners at the distal end, increasing the footprint and tissue-damage. Great efforts have been invested in developing approaches that avoid distal bulky optical elements. However, the fundamental barrier of dynamic optical wavefront-distortions in propagation through flexible fibers limits current approaches to nearly-static or non-flexible fibers. Here, we present an approach that allows holographic, bend-insensitive, coherence-gated, micro-endoscopic imaging using commercially available multi-core fibers (MCFs). We achieve this by adding a partially-reflecting mirror to the distal fiber-tip, allowing to perform low-coherence full-field phase-shifting holography. We demonstrate widefield diffraction-limited reflection imaging of amplitude and phase targets through dynamically bent fibers at video-rate. Our approach holds potential for label-free investigations of dynamic samples.
INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex
Authors: Mascibroda Lauren G. , Shboul Mohammad , Elrod Nathan D. , Colleaux Laurence , Hamamy Hanan , Huang Kai-Lieh , Peart Natoya , Singh Moirangthem Kiran , Lee Hane , Merriman Barry , Jodoin Jeanne N. , Sitaram Poojitha , Lee Laura A. , Fathalla Raja , Al-Rawashdeh Baeth , Ababneh Osama , El-Khateeb Mohammad , Escande-Beillard Nathalie , Nelson Stanley F. , Wu Yixuan , Tong Liang , Kenney Linda J. , Roy Sudipto , Russell William K. , Amiel Jeanne , Reversade Bruno , Wagner Eric J. 
Published: October 2022

AbstractOral-facial-digital (OFD) syndromes are a heterogeneous group of congenital disorders characterized by malformations of the face and oral cavity, and digit anomalies. Mutations within 12 cilia-related genes have been identified that cause several types of OFD, suggesting that OFDs constitute a subgroup of developmental ciliopathies. Through homozygosity mapping and exome sequencing of two families with variable OFD type 2, we identified distinct germline variants in INTS13, a subunit of the Integrator complex. This multiprotein complex associates with RNA Polymerase II and cleaves nascent RNA to modulate gene expression. We determined that INTS13 utilizes its C-terminus to bind the Integrator cleavage module, which is disrupted by the identified germline variants p.S652L and p.K668Nfs*9. Depletion of INTS13 disrupts ciliogenesis in human cultured cells and causes dysregulation of a broad collection of ciliary genes. Accordingly, its knockdown in Xenopus embryos leads to motile cilia anomalies. Altogether, we show that mutations in INTS13 cause an autosomal recessive ciliopathy, which reveals key interactions between components of the Integrator complex.
Mechanistic insights into CO2 conversion chemistry of copper bis-(terpyridine) molecular electrocatalyst using accessible operando spectrochemistry
Authors: Zhang Huihui , Xu Chang , Zhan Xiaowen , Yu Yu , Zhang Kaifu , Luo Qiquan , Gao Shan , Yang Jinlong , Xie Yi 
Published: October 2022

AbstractThe implementation of low-cost transition-metal complexes in CO2 reduction reaction (CO2RR) is hampered by poor mechanistic understanding. Herein, a carbon-supported copper bis-(terpyridine) complex enabling facile kilogram-scale production of the catalyst is developed. We directly observe an intriguing baton-relay-like mechanism of active sites transfer by employing a widely accessible operando Raman/Fourier-transform infrared spectroscopy analysis coupled with density functional theory computations. Our analyses reveal that the first protonation step involves Cu-N bond breakage before the *COOH intermediate forms exclusively at the central N site, followed by an N-to-Cu active site transfer. This unique active site transfer features energetically favorable *CO formation on Cu sites, low-barrier CO desorption and reversible catalyst regeneration, endowing the catalyst with a CO selectively of 99.5 %, 80 h stability, and a turn-over efficiency of 9.4 s−1 at −0.6 V vs. the reversible hydrogen electrode in an H-type cell configuration. We expect that the approach and findings presented here may accelerate future mechanistic studies of next-generation CO2RR electrocatalysts.
Hospitalisation and mortality risk of SARS-COV-2 variant omicron sub-lineage BA.2 compared to BA.1 in England
Authors: Webster H. H. , Nyberg T. , Sinnathamby M. A. , Aziz N. Abdul , Ferguson N. , Seghezzo G. , Blomquist P. B. , Bridgen J. , Chand M. , Groves N. , Myers R. , Hope R. , Ashano E. , Lopez-Bernal J. , De Angelis D. , Dabrera G. , Presanis A. M. , Thelwall S. 
Published: October 2022

AbstractThe Omicron variant of SARS-CoV-2 became the globally dominant variant in early 2022. A sub-lineage of the Omicron variant (BA.2) was identified in England in January 2022. Here, we investigated hospitalisation and mortality risks of COVID-19 cases with the Omicron sub-lineage BA.2 (n = 258,875) compared to BA.1 (n = 984,337) in a large cohort study in England. We estimated the risk of hospital attendance, hospital admission or death using multivariable stratified proportional hazards regression models. After adjustment for confounders, BA.2 cases had lower or similar risks of death (HR = 0.80, 95% CI 0.71–0.90), hospital admission (HR = 0.88, 95% CI 0.83–0.94) and any hospital attendance (HR = 0.98, 95% CI 0.95–1.01). These findings that the risk of severe outcomes following infection with BA.2 SARS-CoV-2 was slightly lower or equivalent to the BA.1 sub-lineage can inform public health strategies in countries where BA.2 is spreading.
Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis
Authors: Qin Le , Cui Yuanbin , Yuan Tingjie , Chen Dongmei , Zhao Ruocong , Li Shanglin , Jiang Zhiwu , Wu Qiting , Long Youguo , Wang Suna , Tang Zhaoyang , Pan Huixia , Li Xiaoping , Wei Wei , Yang Jie , Luo Xuequn , Zhang Zhenfeng , Tang Qiannan , Liu Pentao , Weinkove Robert , Yao Yao , Qin Dajiang , Thiery Jean Paul , Li Peng 
Published: October 2022

AbstractCo-expression of chimeric switch receptors (CSRs) specific for PD-L1 improves the antitumor effects of chimeric antigen receptor (CAR) T cells. However, the effects of trans-recognition between CSRs and PD-L1 expressed by activated CAR T cells remain unclear. Here, we design a CSR specific for PD-L1 (CARP), containing the transmembrane and cytoplasmic signaling domains of CD28 but not the CD3 ζ chain. We show that CARP T cells enhance the antitumor activity of anti-mesothelin CAR (CARMz) T cells in vitro and in vivo. In addition, confocal microscopy indicates that PD-L1 molecules on CARMz T cells accumulate at cell-cell contacts with CARP T cells. Using single-cell RNA-sequencing analysis, we reveal that CARP T cells promote CARMz T cells differentiation into central memory-like T cells, upregulate genes related to Th1 cells, and downregulate Th2-associated cytokines through the CD70-CD27 axis. Moreover, these effects are not restricted to PD-L1, as CAR19 T cells expressing anti-CD19 CSR exhibit similar effects on anti-PSCA CAR T cells with truncated CD19 expression. These findings suggest that target trans-recognition by CSRs on CAR T cells may improve the efficacy and persistence of CAR T cells via the CD70-CD27 axis.