bluuebunny/crossref_metadata_2025_split huggingface dataset:
How to engage health care workers in the evaluation of hospitals: development and validation of BSC-HCW - a cross-sectional study
Authors: Amer Faten , Hammoud Sahar , Khatatbeh Haitham , Alfatafta Huda , Alkaiyat Abdulsalam , Nour Abdulnaser Ibrahim , Boncz Imre , Endrei Dóra 
Published: June 2022

Abstract
Organizations worldwide utilize the balanced scorecard (BSC) for their performance evaluation (PE). This research aims to provide a tool that engages HCWs in BSC implementation (BSC-HCW). Additionally, it seeks to translate the BSC-HCW to Arabic and validate it at Palestinian hospitals. A cross-sectional study, 454 questionnaires were retrieved from 14 hospitals. The composite reliability (CR), interitem correlation (IIC), and corrected item total correlation (CITC) were evaluated. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used. In both EFA and CFA, the scale demonstrated a good level of model fit. All the items had loadings greater than 0.50. All factors passed the discriminant validity. Although certain factors’ convergent validity was less than 0.50, their CR, IIC, and CITC were adequate. The final best fit model had nine factors and 28 items in CFA. The BSC-HCW is the first self-administered questionnaire to engage HCWs in assessing the BSC dimensions following all applicable rules and regulations. The findings revealed that this instrument’s psychometric characteristics were adequate. Therefore, the BSC-HCW can be utilized to evaluate BSC perspectives and dimensions. It will help managers highlight which BSC dimension predicts HCWs’ satisfaction and loyalty and examine differences depending on HCWs’ and hospital characteristics.
The Transient Deformation of Timoshenko’s Plate
Authors: Serdyuk Dmitry Olegovich , Fedotenkov Grigory Valer'evich 
Published: June 2022

Abstract
In this paper we will present an approach to constructing of dynamical spatial Green’s function (elementary solutions, dominant function) for a thin infinite elastic plate of constant thickness. The plate material is anisotropic with a single plane of symmetry, geometrically coinciding with plate’s middle plane. The Timoshenko theory was used for describing the plate movement. Transient spatial Green’s functions for normal displacements and angles of orthogonal alteration to middle surface before deformation of material fiber are built in the Cartesian coordinate system.To construct the Green’s function direct and inverse Laplace and Fourier integral transformations are applied. The originals of Laplace Green’s functions were analytically found with the theorem of residues. To construct Fourier originals a specific method was used based on Fourier series transformation inversion integral connection with Fourier series on a variable interval.Green’s function found for normal displacement made it possible to represent the normal transient function as threefold convolution of Green function with distant load function. The functions of normal distant displacements were constructed in case of the impact of transient total loads concentrated and distributed across rectangular courts. The numerical method of rectangles was used to calculate the convolution integrals. The influence of the concentrated load speed on transient normal displacements of the anisotropic plate was analyzed. As a verification of constructed transient spatial Green’s functions the results of numerical solutions were compared with the results found using known transient Green’s functions for isotropic thin elastic rectangular simply supported Timoshenko’s plate which solutions are constructed using Laplace integral transformation in time and its decomposition into Fourier TS on coordinates. Besides, its confidence was proved analyzing the nature of waves in anisotropic, orthotropic and isotropic plate, found in the process of numerical calculations. The results are represented as diagrams. Examples of calculations are given.
Population attributable fractions for risk factors and disability burden of dementia in Jiangxi Province, China: A cross-sectional study
Authors: Wu Yuhang , Zheng Huilie , Xu Fenfei , Guo Jin , Liu Zhitao , Wang Shengwei , Chen Xiaoyun , Cao Yu , Zou Wei , Hu Songbo 
Published: June 2022

Abstract
Background: In view of the fact that there is no effective treatment for dementia, the number of years that dementia patients have to live with dementia will gradually increase for the rest of their lives, and the disability loss caused by dementia will increase. It is urgent to study the influence of risk factors on dementia by making use of the potential of prevention. The purpose of this study is to quantify the burden of dementia disability attributable to risk factors by assessing the population attributable fractions (PAFs) in Jiangxi Province, which is one of the regions of moderate aging process of China.Methods: The prevalence data of nine risk factors were obtained through the Sixth National Health Service Survey in 2018, which covered 2713 older people. Levin’s formula was used to calculate the PAF for each risk factor for dementia. We adjusted the PAF for communality between risk factors, and used these values to calculate overall weighted PAFs and the years lived with disability (YLDs), which were attributable to nine risk factors.Results: The number of dementia cases and their proportions that can theoretically be prevented by nine identified risk factors were 111636 (99595-120877) and 66.8% (59.6-72.3), respectively. The total YLDs of dementia were estimated to be 61136 (46463-78369) (males: 36434 [24100-49330], females: 23956 [14716-34589]). Physical inactivity (11639 [8845-14920]), low social contact (9324 [7086-11952]), and hearing loss (5668 [4307-7265] were the top three contributors to dementia.Conclusions: The moderate aging areas represented by Jiangxi Province have great potential in the prevention of dementia. Targeted interventions and management of risk factors can effectively reduce the disability burden of dementia.
Recurrent Closed Loop Bowel Obstruction in Third Trimester of Pregnancy: Case Report and Review of Literature
Authors: Araji Tarek , Wang Stephanie , Kandalaft Nadeem , Estroff Jordan , Ahmadzia Homa K. 
Published: June 2022

Abstract
Intestinal obstruction in pregnancy is an uncommon event. It is a high-risk emergency for both the mother and fetus. Diagnosis of obstruction in pregnancy is often delayed due a multitude of reasons including the nonspecific presentation of symptoms, normal laboratory values and hesitancy to perform necessary imaging studies. Closed loop bowel obstruction (CLBO) is a rare type of intestinal obstruction that compromises blood flow, and it is a surgical emergency that requires prompt intervention. We present of case of CLBO in a pregnant patient at 27 weeks of gestation. Unique to her situation was this diagnosis was the second time in the same pregnancy. Our patient had a necrotic bowel segment removed via an open laparotomy. The remainder of her pregnancy was uncomplicated, and she delivered at term a viable male via planned cesarean delivery.
Finishing of grazing crossbred steers supplemented with detoxified castor bean meal (Ricinus communis L.) in the rainy-dry transition period
Authors: Melgar Osman Ronaldo Aguilar , Silva Robério Rodrigues , Silva Fabiano Ferreira da , Santos Laize Viera , Lima Antônio Carlos Ribeiro , Machado Silvia Layse Mendes , Duenez Wbeimar Yamit Sanchez , Santos Marceliana da Conceição , Devia Diana Carolina Cediel , Paixão Tarcísio Ribeiro , Silva João Williams Dias , Costa Gabriel Dallapicola Da , de Carvalho Gleidson Giordano Pinto 
Published: June 2022

Abstract
This study examined different levels of replacement of soybean meal with detoxified castor bean meal in the finishing of crossbred steers on Brachiaria brizantha cv. Marandu pasture during the rainy-dry transition period. Forty Holstein-Zebu crossbred steers with an average initial weight of 395.93 ± 10 kg were randomly allocated to four treatment groups that were supplemented with concentrate containing different levels of castor bean meal replacing soybean meal (0, 30, 60, or 90%; at 0.4% body weight [BW]). The experimental period was 112 days. A completely randomized experimental design was adopted; with regression analysis conducted using the Statistical and Genetic Analysis System (SAEG). Intake and digestibility of dry matter (DM) and nutrients and animal performance were evaluated. The replacement of soybean meal with castor bean meal did not influence (P>0.05) the intakes of DM (kg day-1), organic matter (OM, kg day-1), neutral detergent fiber (NDF, kg day-1 and %BW), non-fibrous carbohydrates (NFC, kg day-1), or total digestible nutrients (kg day-1). However, the intakes of crude protein (CP) and ether extract (EE, kg day-1) decreased as the replacement levels were increased (P<0.05). The digestibility of DM, OM, NDF, and EE did not change, whereas CP digestibility decreased linearly and NFC digestibility increased linearly (P<0.05). The replacement levels did not affect (P>0.05) final live weight, average daily gain, feed conversion, or carcass yield. Detoxified castor bean meal can replace up to 90% of soybean meal in the composition of the supplement without compromising the production performance of steers on Brachiaria brizantha cv. Marandu pasture during the rainy-dry transition period.
ATG5 promotes head and neck squamous cell carcinoma by regulating translation and cell cycle
Authors: Weng Junquan , Liu Huijuan , Zhang Hui , Tang Su , Fan Haidong 
Published: June 2022

Abstract
IntroductionHead and neck squamous cell carcinoma (HNSCC) is the most prevalent malignant tumor of the maxillofacial area. ARGs (autophagy-related genes) are involved in the cell cycle and translation, which will fuel carcinogenesis. Material and methodsTCGA data for ARGs in HNSCC were analyzed. The functional role of the ATG5 in HNSCC was investigated through ATG5 knockdown cell lines.ResultsAccording to the TCGA data, ATG5 was shown to be an adverse prognostic marker. Regardless of tumor stage, grade, or clinical characteristics, HNSCC patients with high ATG5 expression had a poorer survival rate. ATG5 knockdown suppressed the malignant features of HNSCC cell lines. The mechanism study demonstrated ATG5 knockdown could prevent the malignant phenotype of HNSCC by reversing the cell cycle and translation. One of the systems influencing cell cycle control in ATG5-dependent ways might include HDAC2, TTK, and CDK1. MRPL18, MRPL13, and MRPS14 might all be implicated in ATG5-dependent translation regulation.Discussion and conclusion The current research suggests that ATG5 is a key player in cell cycle and translation regulation, as well as poor prognosis in HNSCC.
Pre-training Protein Models with Molecular Dynamics Simulations for Drug Binding
Authors: Wu Fang , Zhang Qiang , Radev Dragomir , Wang Yuyang , Jin Xurui , Jiang Yinghui , Li Stan Z. , Niu Zhangming 
Published: June 2022

Abstract
The latest biological findings discover that the motionless 'lock-and-key' theory is no longer applicable and the flexibility of both the receptor and ligand plays a significant role in helping understand the principles of the binding affinity prediction. Based on this mechanism, molecular dynamics (MD) simulations have been invented as a useful tool to investigate the dynamical properties of this molecular system. However, the computational expenditure prohibits the growth of reported protein trajectories. To address this insufficiency, we present a novel spatial-temporal pre-training protocol, PretrainMD, to grant the protein encoder the capacity to capture the time-dependent geometric mobility along MD trajectories. Specifically, we introduce two sorts of self-supervised learning tasks: an atom-level denoising generative task and a protein-level snapshot ordering task. We validate the effectiveness of PretrainMD through the PDBbind dataset for both linear-probing and fine-tuning. Extensive experiments show that our PretrainMD exceeds most state-of-the-art methods and achieves comparable performance. More importantly, through visualization, we discover that the learned representations by pre-training on MD trajectories without any label from the downstream task follow similar patterns of the magnitude of binding affinities. This strongly aligns with the fact that the motion of the interactions of protein and ligand maintains the key information of their binding. Our work provides a promising perspective of self-supervised pre-training for protein representations with very fine temporal resolutions and hopes to shed light on the further usage of MD simulations for the biomedical deep learning community.
Comparison of Three Different Biomaterials Used In In Vitro Molar Apexification Models
Authors: DUMAN Canan , Kalaoglu Elif Ece , CAPAN Belen SIRINOGLU , OCAK Mert , BILECENOGLU Burak 
Published: June 2022

Abstract
Objectives: New biomaterials had some advantages such as mixing and easier application as compared to traditional MTA in single-step apexification method. This study aimed to compare the three biomaterials used in the apexification treatment of immature molar teeth in terms of the time spent, the quality of the canal filling and the number of x-rays taken to complete the process.Methods: The root canals of the extracted thirty molar teeth were shaped with rotary tools. To obtain the apexification model, ProTaper F3 was used retrograde. The teeth were randomly assigned into three groups based on the material used to seal the apex; Group 1:Pro Root MTA, Group 2:MTA Flow, Group 3: Biodentine. The amounts of the filling, the number of radiographs taken until treatment completion and the treatment duration were recorded. Then teeth were fixed for micro computed tomography imaging for quality evaluation of canal filling.Results: Biodentine was superior than the other filling materials according to time. MTA Flow provided greater filling volume than the other filling materials in the rank comparison for the mesiobuccal canals. MTA Flow had greater filling volume than ProRoot MTA in the palatinal/distal canals(p=0.039). Biodentine had greater filling volume more than MTA Flow in the mesiolingual/distobuccal canals(p =0.049).Conclusions: MTA Flow was found as a suitable biomaterial according to the treatment time and quality of root canal fillings.
Assessment of Carbon Emission Reduction Contribution of Chinese Power Grid Enterprises Based on MCS-GA-ELM Method
Authors: Li Jinchao , Sun Zihao , Lu Shiqiang 
Published: June 2022

Abstract
To achieve China's "double carbon" goal, it is necessary to make quantitative evaluation of the power grid enterprises’ contribution to carbon emission reduction. This paper analyzes the contribution of power grid enterprises to carbon emission reduction from three points: power generation side, power grid side and user side. Then, PLS-VIP method is used to screen the key influencing factors of carbon emission reduction contribution of power grid enterprises from three aspects: consumption of clean energy emission reduction, reduction of line loss emission reduction and substitution of electric energy. Based on GA-ELM combined machine learning algorithm, we establish an intelligent evaluation model of power grid enterprises’ carbon emission reduction contribution. Furthermore, according to the distribution law of key influencing factors, this paper uses Monte Carlo method to calculate the contribution of power grid enterprises to carbon emission reduction by scenario, so as to evaluate the contribution of power grid enterprises to carbon emission reduction. Finally, combined with the relevant data of power grid enterprises from 2003 to 2019, this paper makes an empirical study on the completion of carbon emission reduction contribution and the promotion path.
Glucocorticoid Receptor Regulated KCNA5 Mediates Cell Proliferation in Human Fetal Membranes
Authors: Cunningham Sarah J , Barrera Alejandro , Sankaranarayanan Laavanya , Allen Terrence K , Reddy Timothy E 
Published: June 2022

Abstract
Preterm birth is a major public health issue, affecting approximately 10% of pregnancies in the United States. A major identifiable cause of preterm birth is preterm premature rupture of membranes (PPROM). PPROM is a pregnancy complication in which the amnion and chorion weaken and rupture prior to 37 weeks of pregnancy and before contractions have begun. PPROM is responsible for 30–40% of preterm birth cases. Recently, PPROM has been closely linked to maternal stress, leading us to hypothesize that glucocorticoid signaling may contribute to PPROM. We measured the gene expression effects of glucocorticoids in primary amnion cells using RNA-seq. KCNA5 emerged as a potential GR regulated gene. To measure the effects of KCNA5 on cell proliferation in primary amnion epithelial cells, we used siRNA to reduce KCNA5 expression and Cas9-based epigenome editing to increase KCNA5 expression in HEK293T cells; followed by cellular assays to measure effects of proliferation and apoptosis. KCNA5 knockdown significantly increased cell proliferation without appearing to impact apoptosis. CRISPR-mediated over expression of endogenous KCNA5 significantly decreased cell proliferation. Decreases in amnion epithelial proliferation could impair the ability of these cells to repair microfractures in the membrane and lead to overall membrane weakening consistent with PPROM.
Pathogenomic analysis of Macrococcus caseolyticus Strain DaniaSudan
Authors: Ali Dania , Bakrye Afar Al , Nasri Hind , Khaier Mona 
Published: June 2022

Abstract
This study pathogenomic to gain genetic characterizations of the first pathogenic strains of Macrococcus caseolyticus, obtained from the donkey in Sudan. The in-silico analysis revealed that a total of (714 genes) were associated with carbohydrate metabolism (187 genes), amino acid and derivatives (138 genes), protein metabolism (163 genes), cofactors, vitamins, prosthetic groups, pigments (103 genes), membrane transport (26 genes), RNA metabolism (37 genes) and stress response (29 genes). In addition, (31 genes) identified in the strain were involved in virulence, disease, and defense. Multiple antibiotic resistances were revealed (13gens) including methicillin resistance (mecI, mecA, mecR1) penicillin binding (PonA, pbpA, pbpH, pbpF and pbpB), Multidrug resistance (mdtH_1, ykka, ykkc and mdtH_2), Tetracycline resistance (tetA, tet38), multidrug export (emrB), multidrug efflux pump (sdrM, sepA) and putative multidrug resistance (emrK). Also, stress responses were (yug1_1, yug1_2, ydaG, ysnF, ydaD and ysnF) and cold shocks were (cspA_1, cspA_2 and cspG). Furthermore, hemolysin (HyA), staphylococcal secretory antigen (ssaA2, ssaA) and (7) seven Murein hydrolase regulation and cell death were identified. The organism consists of Tetracycline resistance gene in the plasmid and Three CRISPRs dan_contig_1, dan_contig_14 and dan_contig_27. The probability of being a human pathogen is 0.253 (PathogenFinder algorithm). Strain DaniaSudan is the first pathogenic strain of Macrococcus caseolyticus isolated from animal.
Fate of Non-Recyclable Plastic Wastes: Material Flow Analysis, Leakage Hotspot Modelling, and Management Strategies
Authors: Rinasti Aprilia Nidia , Ibrahim Indradhi Faisal , Gunasekara Kavinda , Koottatep Thammarat , Winijkul Ekbordin 
Published: June 2022

Abstract
Low priority on waste management has impacted the complex environmental issue, where this study found out up to 24.3% of waste generation in Jakarta and Bandung is emitted to the waterway due to the high intensity of human activity in the urban area. In this study, we investigated the viable integration between material flow analysis and leakage hotspot modelling to improve the management strategy of the plastic pollution in the water system and open environment. Using the multi-criteria assessment through the plastic leakage from its management, a material flow analysis has developed on the city scale. Comprehensively identifying using potent identification and hydrological characterization, plastic waste from Jakarta city has occasionally estimated 2603 ton discarded to Ciliwung River while the plastics from Bandung Area has contributed to 1547 ton, addressing Cikapundung River as the main tributary of Citarum mainstream in annual basis.
Horizontal, random, and vertical structuring of cellulose nanofibres by one-pot electrophoretic and electrochemical deposition
Authors: Kasuga Takaaki , Saito Tsuguyuki , Koga Hirotaka , Nogi Masaya 
Published: June 2022

Abstract
Biomimicry and the development of sophisticated materials can derive inspiration from the nanoscale component orientation and hierarchical structures found in living organisms. Herein, a simple and flexible strategy to construct a sophisticated hierarchical structure based on electrophoretic and electrochemical deposition is reported. Cellulose nanofibres (CNFs), which were used as model materials, were deposited on anode in an aqueous dispersion and fixed in an oriented state, which could be seamlessly altered from horizontal to vertical orientation relatively to the electrodes depending on the applied voltage between the electrodes. The oriented CNF hydrogels not only exhibited anisotropic mechanical properties but also formed complex orientations and hierarchical structures, such as cartilage- and plant stem-like configurations upon varying the electrode shape and applied voltage. This electrophoretic and electrochemical approach was also applied to achieve control over the drying-related shrinkage of the CNF hydrogels, which enabled the fabrication of highly functional dried moulded materials made of rigid CNFs. This simple and flexible technology has the potential to be applied to various materials and thus is expected to contribute to a wide range of fields, such as biomimicry, the formation of highly functional materials made of nanomaterials, and the production of sustainable and functional mouldings.
Experimental study on injection of ferrous sulphate for remediation of a clayey soil contaminated with hexavalent chromium
Authors: Hu Guang , He Yong , Zhu Kao-fei , Zhang Zhao , Lou Wei , Zhang Ke-neng , Chen Yong-gui , Wang Qiong 
Published: June 2022

Abstract
In-situ remediation of the Cr(Ⅵ) contaminated clayey soil remains challenging due to the low hydraulic conductivity and high ion adsorption capacity of the clays. In this study, the injection tests of ferrous sulphate (FeSO4) for a clayey soil contaminated with hexavalent chromium (Cr(Ⅵ)) were performed to explore the feasibility of FeSO4 solution for remediation of Cr(Ⅵ) contaminated soil under different injection pressures. The results show that the injection of FeSO4 solution under the pressure of 30 kPa, 70 kPa, and 100 kPa caused the hydraulic conductivities of the specimens to decrease by 36.5%, 38.7% and 32.2%, respectively. This phenomenon could be attributed to the formation of the mixed iron(Ⅲ)/chromium(Ⅲ) hydroxide, a process for which scanning electron microscopy with energy-dispersive X-ray microanalysis provided direct evidence. Moreover, the mobility capacity of Fe(Ⅱ) was stronger under high pressure (70 kPa, 100 kPa) as indicated by Fe profiles in specimens after remediation under different injection pressures. The range of iron increment at 100 kPa was 3.2–11.9 (g/kg). However, the maximum iron increment at 30 kPa was only 5 (g/kg) and the migration of Fe(Ⅱ) was limited, which was less than 2.5 cm. In addition, the injection pressure of 70 kPa was the most efficient for remediation of Cr(Ⅵ) contaminated soil under the experimental condition in present work, which the remediation efficiency was 87.43%-95.12%. As injection pressure increased, Cr(Ⅵ) leaching increased. Therefore, these experimental results can be used as a reference for remediation of chromium contaminated soil by in-situ injection.