bluuebunny/crossref_metadata_2025_split huggingface dataset:
A global study on applicability of ISO 18404:2015 for SMEs: an exploratory qualitative study
Authors: Antony Jiju , Swarnakar Vikas , Salentijn Willem , Shokri Alireza , Doulatabadi Mehran , Bhat Shreeranga , McDermott Olivia , Jayaraman Raja , Sony Michael 
Published: October 2022

PurposeISO 18404:2015 standard defines the proficiencies to the attainment of distinct competency levels with either Lean Manufacturing or Six Sigma or separately combined strategy Lean Six Sigma (LSS). The purpose of this paper is to perform a detailed investigation of the applicability of current LSS competency standard in SMEs and examine the need for further improvement.Design/methodology/approachA qualitative-based semi-structured interview method was utilized globally by interviewing a group of LSS professionals with knowledge about the LSS implementation working in different leading organizations. All participants were asked to review the standard before the interview process to ensure that they are familiar with the standard.FindingsThe results reveal that the current ISO 18404:2015 standard does not fit SMEs to implement the LSS approach as it has several shortfalls that need to be fixed before its adoption or an urgent need to develop a more customized LSS standard for SMEs. The outcome further helps organizations understand theoretical knowledge about ISO 18404:2015, its role in operational excellence implementation, pros, cons, critical success factors and required changes for further improvement within the standard.Research limitations/implicationsThere were very limited baseline studies in the literature. A mixed method strategy that includes qualitative and quantitative data would yield better data so that more robust outcomes can be derived from the research.Originality/valueTo the best of authors' knowledge, this is the first empirical research on the applicability of ISO 18404:2015 for SMEs, which encapsulate opinions of LSS professionals working in several SMEs.
Genomic profiling with whole‐exome sequencing revealed distinct mutations and novel pathways in Asian melanoma
Authors: Chiu Yu‐Jen , Weng Hui‐Ying , Lin Yen‐Yu , Lin Yung‐Feng , Yeh Yi‐Chen , Perng Chern‐Kang , Ma Hsu , Tsai Shih‐Feng , Chou Teh‐Ying 
Published: October 2022

AbstractThe clinical characteristics of malignant melanoma are highly variable between patient populations of different ethnicities. To explore the underlining genetic variations, we reviewed the clinical data of 242 malignant melanoma cases from Taiwan and among them submitted formalin‐fixed paraffin‐embedded tissue samples from 37 patients for whole‐exome sequencing to identify the mutational signatures, tumor mutation burden and specific gene mutations. The genomic profiles and clinical outcomes were compared with the information derived from the publicly available TCGA and TGEN databases. Mutation signature 12 was the dominant signature in Taiwanese patients and represented approximately 45% of the mutation signatures observed. In contrast, mutation signature 7 was the most prominent among cases available in the TCGA database. Common gene mutations found in the TCGA melanoma dataset were not frequently found in melanomas from Taiwanese patients. There were a significant number of specific gene mutations that exclusively occurred in acral subtype but not in non‐acral subtype melanomas, and vice versa. While certain common mutations form a shared core of genetic features, there appear to be specific genetic pathways that are involved in the occurrence of melanomas that grow in non‐UV‐exposed areas. Our findings have shed light on the tumorigenesis pathways involved in malignant melanoma.
UVA1 radiation attenuates pro‐inflammatory functions in human monocytes
Authors: Peters Anna Franziska , Kusche Yvonne , Gerdkamp Henrike , Nattkemper Eva , Vischedyk Kerstin , Münck Niels‐Arne , Weishaupt Carsten , Roth Johannes , Barczyk‐Kahlert Katarzyna , Sunderkötter Cord , Ehrchen Jan Mauno 
Published: October 2022

AbstractUVA1 therapy is effective in the treatment of inflammatory and autoimmune skin diseases. The mode of action of UVA1 therapy is not completely understood and especially data on cells of the innate immune system like monocytes, which are critically involved in many inflammatory processes, are sparse. We wanted to answer the question whether UVA1 irradiation alters functional properties of human monocytes. We treated human peripheral blood monocytes in vitro with 2 J/cm2 UVA1 light, incubated the cells for 48 h and examined both functional properties and alterations in the gene and protein expression profile. While UVA1 did not alter cell viability or susceptibility to apoptosis inducing agents, it decreased the capacity of monocytes for phagocytosis and to eliminate infectious agents like Leishmania major. Moreover, we measured a significantly reduced production of interleukin (IL)‐1β mRNA in lipopolysaccharide activated monocytes after UVA1 treatment. Importantly, UVA1‐treated monocytes not only produce less IL‐1β, but also upregulate expression of the anti‐inflammatory IL‐1β decoy receptor. Our data provide evidence that UVA1 radiation not only interferes with fundamental monocyte properties like phagocytosis, pathogen killing and activation, but could also specifically attenuate pro‐inflammatory IL‐1 effects. This might constitute a hitherto unknown anti‐inflammatory mechanism of UVA1 in human monocytes.
Interrogating nonsuicidal self‐injury disorder through a feminist psychiatric disability theory framework
Authors: Redikopp Sarah , Smith Sarah 
Published: October 2022

AbstractThis article explores the proposed psychiatric diagnostic category of nonsuicidal self‐injury disorder (NSSID) through the lens of feminist psychiatric disability theory. Mobilising insights from labelling theory’s accounts of stigma and recovery, in conjunction with critical and feminist disability theory’s attention to emotional and physical pain, we suggest that a feminist psychiatric disability approach to NSSID can illuminate the limits of a fully demedicalised engagement with self‐injury. While remaining critical of psychiatrisation processes, we explore the implications of ‘strategic (dis)identifications’ with illness labels as mechanisms through which to manage and access care, treatment and recovery. Such a nuanced account engenders more deeply material considerations of pain, stigma, treatment and ‘cure’ at the site of NSSID, opening new avenues of engagement with self‐injury for sociologists and critical disability scholars alike.
(When) do electoral mandates set the agenda? Government capacity and mandate responsiveness in Germany
Authors: GUINAUDEAU BENJAMIN , GUINAUDEAU ISABELLE 
Published: October 2022

AbstractIn democracies, electoral mandates are meant to shape public policy. But how much leeway do elected representatives actually have to implement it? Influential scholars think that (horizontal and vertical) institutional hurdles, budget constraints and political pressure dilute mandate responsiveness, but empirical evidence for this important claim remains scarce. This article provides a theoretical model and an empirical account of the extent to which different types of constraints limit the capacity of governing parties to set their electoral priorities on the agenda. Using fixed‐effects Poisson regression on German electoral and legislative priorities over a period of over three decades (1983–2016), we conclude that policies reflect electoral priorities to a greater extent than scholarship has acknowledged so far. We do confirm, however, the constraining effects of Europeanization, shrinking budget leeway, intra‐coalition disagreement and low executive popularity. We elaborate on the implications for theories of public policy, democratic representation and comparative politics.
Multimedia stream hashing: A forensic method for content verification
Authors: Wales Gregory S. , Smith Jeff M. , Lacey Douglas S. , Grigoras Catalin 
Published: October 2022

AbstractForensic examination of digital audio, video, and images frequently requires transforming multimedia data from one format to another. The transformative activity may cause changes to the administrative elements of the file but leave the multimedia streams unchanged and intact. However, the forensic science community has a method knowledge gap in accurately determining if the multimedia streams changed or remained the same in the transformative processes. This paper illustrates the practical use of multimedia stream hashing as a forensic method for verifying multimedia content. A universal stream hashing tool decodes the multimedia stream data at rest in a file container. Subsequently, it calculates the data stream hash using reference video, audio, and image codecs. This paper illustrates that the multimedia stream hashing method can accurately confirm the integrity of digital images, videos, and audio following transmission, transcoding, or re‐containerization. Our findings confirmed that stream hashing could accurately detect changes in multimedia streams during transcoding. Furthermore, the stream hashing method can also accurately detect matching multimedia streams. In addition, this paper verified the forensic use of the multimedia stream hash method while establishing the error rate for its use. The hash algorithms used in stream hashing have zero false negative rates by design. However, the false positive (error rate) is extremely low and depends on hashing algorithm. Finally, we recommend the forensic science community adopt the multimedia stream hashing method as an initial testing method. The method can verify a multimedia stream's conversion (transcoding) from one codec to another using FFmpeg.
The impact of institutional investors on ESG: Evidence from China
Authors: Liu Jinchi , Xiong Xiong , Gao Ya , Zhang Jin 
Published: October 2022

AbstractThis paper studies the influence of institutional ownership on the Chinese A‐shares' ESG performance. Findings reveal the positive improvement from institutional investors, and this impact is stronger in firms with better‐expected ESG performance and low initial ESG performance. Besides, heterogeneous institutional investors have different influences, and only a pressure‐resistant institution plays the promotion role. Further studies based on the period following the financial crisis and when emphasising the environmental protection policy reveal that financial motivation and reputation motivation could be the reason for institutional holding. Our findings are robust after using the instrumental variable analysis, controlling for firm fixed effects, and replacing institutional holdings, and could be beneficial for the governance of firms in China.
Market sentiment to COVID‐19 and the Chinese stock market
Authors: Xu Liao , Chen Jilong , Xu Hao 
Published: October 2022

AbstractWe classify the market sentiment to COVID‐19 into expected and unexpected components and then examine their particular impacts on the stock market. We find that unexpected sentiment causes fluctuations in the stock market more than expected sentiment does. However, unexpected sentiment cannot affect stock market informativeness despite the remarkable informational effect of expected sentiment. Moreover, the relation between expected sentiment and stock market fluctuation or informativeness is one‐way, whereas there exists a two‐way interaction between unexpected sentiment and stock market fluctuation. This further confirms that expected sentiment is informational, whereas unexpected sentiment is quite noisy and informationally harmful.
Presence and development of diabetic retinopathy in 153 238 patients with type 2 diabetes in the Danish Registry of Diabetic Retinopathy
Authors: Grauslund Jakob , Pedersen Frederik Nørregaard , Andersen Nis , Andresen Jens , Bek Toke , Dinesen Sebastian , Hajari Javad , Heegaard Steffen , Højlund Kurt , Laugesen Caroline Schmidt , Kawasaki Ryo , Möller Sören , Schielke Katja Christina , Thykjær Anne Suhr , Stokholm Lonny 
Published: October 2022

AbstractPurposeThe purpose of the study was to evaluate the prevalence and incidence of diabetic retinopathy (DR) along with associated markers in patients with type 2 diabetes in the Danish DR‐screening programme.MethodsWe included all persons with type 2 diabetes in the Danish Registry of Diabetic Retinopathy, who had attended at least one episode of DR screening in 2013–2018. DR was classified as levels 0–4 indicating increasing severity. Data were linked with various national health registries to retrieve information on diabetes duration, marital status, comorbidity and systemic medication.ResultsAmong 153 238 persons with type 2 diabetes, median age and duration of diabetes were 66.9 and 5.3 years and 56.4% were males. Prevalence and 5‐year incidences of DR, 2‐step‐or‐more progression of DR and progression to proliferative DR (PDR) were 8.8%, 3.8%, 0.7% and 0.2%, respectively. In multivariable models, leading markers of incident DR and progression to PDR were duration of diabetes (HR 1.98, 95% CI 1.87–2.09; HR 2.89, 95% CI 2.34–3.58 per 10 years of duration) and use of insulin (HR 1.88, 95% CI 1.76–2.01; HR 2.40, 95% CI 1.84–3.13), while the use of cholesterol‐lowering medicine was a protecting marker (HR 0.87, 95% CI 0.81–0.93; HR 0.70, 95% CI 0.52–0.93). From 2013 to 2015, 3‐year incidence rates of PDR decreased from 1.22 to 0.45 events per 1000 person‐years.ConclusionNationally, among Danish individuals with type 2 diabetes attending DR screening, we identified duration of diabetes and use of insulin as the most important predictor for the development of DR, while cholesterol‐lowering medicine was a protective factor.
Facing academic problems: Longitudinal relations between parental involvement and student academic achievement from a self‐determination perspective
Authors: Teuber Ziwen , Sielemann Lena , Wild Elke 
Published: October 2022

AbstractBackgroundThe relation between parental involvement and student achievement has been of research interest for many decades. Although the idea of reciprocal processes between parent and child was proposed 40 years ago, very few efforts have been made to investigate reciprocal relations between parental involvement and student achievement.AimsUsing self‐determination theory, this study investigated the longitudinal associations of the manner of parental involvement (i.e., autonomy‐supportive or controlling) in children's academic problems with children's academic achievement. This study further addressed the recently intensely debated methodological issue of examining reciprocal relations by comparing a random‐intercept cross‐lagged panel model (RI‐CLPM) with the traditional cross‐lagged panel model (CLPM).Sample and MethodsA RI‐CLPM and a traditional CLPM were applied to 5‐year longitudinal data including 1465 secondary school students (Mage at T1 = 10.82 years, SD = 0.62). In both models, we controlled for students' gender, school type, socioeconomic status and cognitive ability.ResultsThe results show that the RI‐CLPM fitted the data better than the CLPM. Trait‐like stability was found for both forms of parental involvement and academic achievement. At the between‐person level, controlling involvement related to lower achievement, whereas no correlation between autonomy‐supportive involvement and achievement was found. At the within‐person level, there were positive reciprocal relations between autonomy‐supportive involvement and achievement, whereas controlling involvement was not associated with achievement.ConclusionsThis study contributes substantially to the understanding of the relations between parental involvement in children's academic problems and children's academic achievement by simultaneously taking between‐person differences and within‐person processes into consideration.
Mechanism of RIP2 enhancing stemness of glioma cells induces temozolomide resistance
Authors: Wang Xiao‐liang , Jiao Bao‐hua , Wu Jian‐liang , Yang Jian‐kai , Hu Yu‐hua , Cui Kai 
Published: October 2022

AbstractAimsWe aimed to investigate the role of receptor‐interacting protein 2 (RIP2) in regulation of stemness of glioma cells and chemotherapy resistance.MethodsPlasmid transfection was used to overexpress RIP2. Chemical inhibitors were used to inhibit RIP2 or NF‐κB activity. Cancer stemness of glioma cells was investigated by sphere formation assays, clone formation assays, and xenograft tumor formation assays. The expression of RIP2, p‐NF‐κB, IκBα, CD133, or SOX‐2 was detected by Western blotting and immunofluorescence. Apoptosis was detected by flow cytometry. Immunohistochemical staining was used to detect the expression of RIP2, CD133, and SOX‐2 in xenograft tumor tissue. The effect of the RIP2/NF‐κB pathway on temozolomide (TMZ) resistance was evaluated by xenograft tumor assay.ResultsTransfection with RIP2 plasmid enhanced the sphere formation capability of U251 cells, clone formation capability, and xenograft tumor formation capability. RIP2 could mediate TMZ resistance by upregulating the expression of CD133 and SOX‐2 by activating the NF‐κB pathway. Both RIP2 inhibitor GSK583 and the NF‐κB inhibitor SC75741 could reverse the resistance of U251 cells to TMZ.ConclusionRIP2 mediates TMZ resistance by regulating the maintenance of stemness in glioma cells through NF‐κB. Interventions targeting the RIP2/NF‐κB pathway may be a new strategy for TMZ‐resistant gliomas.
Diffusion along perivascular spaces provides evidence interlinking compromised glymphatic function with aging in Parkinson's disease
Authors: Cai Xin , Chen Zhenzhen , He Chentao , Zhang Piao , Nie Kun , Qiu Yihui , Wang Limin , Wang Lijuan , Jing Ping , Zhang Yuhu 
Published: October 2022

AbstractAimsThe aim of the study was to evaluate the glymphatic function and its related factors in patients with Parkinson's disease (PD) and patients with PD of different ages using the diffusion tensor image analysis along the perivascular space (DTI‐ALPS) method.MethodsMedical records and imaging data of 93 patients with idiopathic PD and 42 age‐ and sex‐matched healthy controls (HCs) were retrospectively reviewed and analyzed. The diffusivity along the perivascular spaces, projection fibers, and association fibers were calculated on diffusion tensor imaging (DTI) to acquire the analysis along the perivascular space (ALPS) index.ResultsPD patients exhibited a reduced ALPS index compared with the HCs. Negative correlations between the ALPS index and clinical information including age, age at disease onset, Parkinson's disease sleep scale 2nd version (PDSS‐2) scores, and history of diabetes mellitus were revealed in the PD group. Besides, a negative correlation between the ALPS index and the severity of motor symptoms was identified in the subgroup aged 65 and above, rather than in the younger ones.ConclusionsThe results demonstrate that reduced ALPS index, a potential noninvasive measure of compromised glymphatic activity, is involved in the pathophysiology of PD, especially in the aged ones and those with sleep disorders.
Infections with Herpes simplex and Varicella zoster virus
Authors: Wilms Larissa , Weßollek Katharina , Peeters Theresa Barbara , Yazdi Amir Sadegh 
Published: October 2022

SummaryHuman herpes viruses belong to the DNA viruses and are among the most common viral pathogens. Currently, eight human herpes viruses have been characterized. Primary infection is typically followed by virus latency. Viral reactivations are more often symptomatic than primary infections and lead more often to medical consultation. In daily practice, infections with herpes simplex virus (HSV) and varicella zoster virus (VZV) are the most common. If HSV primary infections become clinically manifest, they are often accompanied by systemic symptoms whereas manifest HSV reactivations are usually harmless, self‐limiting and present as grouped vesicles on an erythematous base (herpetiform). Primary VZV infection leads to the clinical picture of varicella (chickenpox). VZV reactivation manifests clinically as shingles and can be accompanied by severe acute neuralgiform pain. In immunosuppression, complicated (necrotizing, ulcerative, hemorrhagic, generalized) manifestations may occur.The diagnosis is usually made clinically. Therapeutic options include topical agents and systemic antivirals. Adequate therapeutic management includes the recognition and treatment of complications such as the possible involvement of other organ systems and pain. Infection during pregnancy may result in transmission to the unborn child.
Change in pharmacodynamic variables following once‐weekly tirzepatide treatment versus dulaglutide in Japanese patients with type 2 diabetes (SURPASS J‐mono substudy)
Authors: Yabe Daisuke , Kawamori Dan , Seino Yusuke , Oura Tomonori , Takeuchi Masakazu 
Published: October 2022

AbstractAimTo evaluate the pharmacodynamic effects of tirzepatide, a novel dual glucagon‐like peptide‐1 receptor and glucose‐dependent insulinotropic polypeptide receptor agonist, compared with dulaglutide in patients with type 2 diabetes.Materials and MethodsSURPASS J‐mono was a 52‐week, multicentre, randomized, double‐blind, parallel, active‐controlled, Phase 3 study, conducted in Japan. This substudy of SURPASS J‐mono evaluated postprandial metabolic variables and appetite after a meal tolerance test, and body composition measured by bioelectrical impedance analysis.ResultsOf 636 participants in SURPASS J‐mono, 48 were included in this substudy and assigned to tirzepatide 5 mg (n = 9), tirzepatide 10 mg (n = 11), tirzepatide 15 mg (n = 9), or dulaglutide 0.75 mg (n = 19). Participants had a mean (standard deviation) age of 58.6 (7.5) years, duration of diabetes of 6.0 (6.3) years, and body mass index of 27.5 (3.5) kg/m2. Mean glycated haemoglobin at baseline was 66 mmol/mol (8.22%). Following a standardized meal test, statistically significant differences in change from baseline in area under the concentration versus time curve from time zero to 6 h after dose for glucose, insulin, glucagon, C‐peptide and triglycerides were observed in all tirzepatide treatment arms, except triglycerides at 10 mg, compared with dulaglutide at Week 32. For body composition, tirzepatide 10 mg and 15 mg resulted in a significant reduction in body weight, and all doses of tirzepatide resulted in a significant reduction in body fat mass at Week 52.ConclusionsCompared with dulaglutide, tirzepatide showed greater potential for normalizing metabolic factors after a standardized meal. Tirzepatide reduced body weight and body fat mass.
How do fiscal rules shape governments' spending behavior?
Authors: Vinturis Cezara 
Published: October 2022

AbstractAt odds with the large literature devoted to the fiscal discipline effects of fiscal rules, only few contributions investigate their impact on public spending. Estimations based on the entropy balancing method reveal the following causal effects: fiscal rules significantly reduce total public spending and public consumption, leave public investment mostly unaffected, and increase the public investment‐to‐public consumption ratio. Moreover, the type of fiscal rule and countries' level of economic development influence the way fiscal rules affect public spending. Lastly, fiscal rules' features are a major driving force of the way governments change public spending in the presence of fiscal rules.