bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective treatment of canine chronic cutaneous lupus erythematosus variants with oclacitinib: Seven cases
Authors: Harvey Richard G. , Olivrī Alla , Lima Tatiana , Olivry Thierry 
Published: October 2022

AbstractBackgroundThe treatment of canine chronic cutaneous lupus erythematosus (CCLE) variants generally requires immunosuppression, which often results in potentially severe adverse effects. Janus kinase inhibitors, like oclacitinib, might be a valuable treatment option due to their rapid inhibition of the action of interferons known to be relevant in the pathogenesis of CCLE.ObjectivesTo report the efficacy and safety of oral oclacitinib for the treatment of canine CCLE variants.AnimalsSeven dogs were diagnosed with CCLE based on clinical signs and compatible histopathological findings.Materials and methodsOclacitinib was administered at the induction dosage of 0.45 mg/kg twice daily to 1.8 mg/kg once daily. The response to treatment was graded as ‘good’ when there was ≥50% lesion reduction, or as ‘complete remission’ if all active lesions had resolved. Complete blood counts were performed at variable intervals.ResultsA complete remission of all lesions was obtained in the dog with exfoliative cutaneous lupus erythematosus, both dogs with mucocutaneous lupus erythematosus and three of four dogs with facial discoid lupus erythematosus (FDLE); a good response was seen in the remaining dog with FDLE. The first visible improvement of signs was seen within 2‐to‐3 weeks, while the time to complete remission was around 2 months. Clinical adverse effects were not seen, and haematological parameters remained within the reference range.Conclusions and Clinical RelevanceOclacitinib may be considered an effective treatment option for different variants of canine CCLE.
Subpalpebral lavage placement for remote topical administration of ocular medications in 12 dogs: A retrospective review and assessment of owner perception
Authors: Parker Josie , Ioannides Joy , Kumaratunga Vim , Preston Juliette , Hartley Claudia , Donaldson David 
Published: October 2022

AbstractObjectiveThe aim of this study was to describe the placement of subpalpebral lavage (SPL) systems in 12 dogs (15 eyes) intolerant of topical ocular medications to assess the suitability, complications encountered and owner perception of use.Animals StudiedRetrospective review of dogs that underwent SPL placement for treatment of ocular disease at the Ophthalmology Department, University of Bristol Small Animal Hospital between 2017 and 2021.Procedure(s)Data recorded included signalment, history, diagnosis, treatment, reason for SPL placement, uni‐ or bilateral placement, duration of placement, complications, and outcome. Owner perception was assessed using an online questionnaire. Statistical analysis included McNemar and Wilcoxon signed‐ranks tests.ResultsTwelve dogs (15 eyes) underwent SPL placement. Eleven owners completed the online questionnaire. Corneal ulceration was the most common disease requiring SPL placement (n = 13/15 eyes, 86.7%). Most cases received multimodal topical therapy (n = 9/15 eyes, 60.0%) via SPL. Owners administered medication 6.63 times daily via SPL (range 1–16 applications/day). All dogs requiring ongoing topical medication (n = 8/12, 66.7%) were trained to accept direct administration during SPL treatment. Statistically significant improvements in medication compliance, ease of application, and reduced perceived risk of iatrogenic ocular injury were reported by owners (p‐value = .001, .004, and .031 respectively). Minor complications were infrequently reported but an excellent outcome was achieved for all eyes.ConclusionSubpalpebral lavage placement provides a practical and safe solution for the provision of frequent multimodal ocular medication when treating patients with a challenging temperament.
Effects of mobile technology-based interventions in promoting mental health and psychosocial wellbeing among young people in low-and middle-income countries: a systematic review protocol
Authors: Rai Devika , Bhattacharjee Shuvarthi , Dhakal Rabina , Chattopadhyay Kaushik , Neupane Dinesh 
Published: October 2022

ABSTRACT

Objective:
This review will aim to examine the effectiveness of mobile-based technologies among young people (10 to 24 years) in low- and middle-income countries in order to promote their mental health and psychosocial well-being. Such promotional interventions may be in the form of mobile technology–based education, information, or psychosocial counseling.

Introduction:
Young people in low- and middle-income countries have limited access to mental health services. Mobile-based technologies, such as remote consultations, telehealth, and smartphone applications, can offer improved access to mental health services; however, to the best of our knowledge, there are no systematic reviews of effectiveness on this topic.

Inclusion criteria:
Evidence sources from low- and middle-income countries involving mobile-based technologies for mental health and psychosocial support interventions for young people will be included. All experimental and observational studies published in English from 2010 to 2022 will be included.

Methods:
The review will follow JBI methodology for systematic reviews of effectiveness. Embase (Ovid), CINAHL (EBSCO), PsycINFO (ProQuest), AMED (Ovid), HMIC (Ovid) MEDLINE (PubMed), and Web of Science will be searched. Gray literature will be identified through Directory of Open Access Journals, ProQuest Dissertations and Theses, EThOs, Asia eHealth Information Network, Google Scholar, and Grey Literature Report. Retrieved articles will be screened against the inclusion criteria, followed by an assessment by 2 independent reviewers for methodological quality using standardized JBI appraisal tools. Data extraction will be done using standardized JBI data extraction tools. Narrative synthesis will be preferred if meta-analysis is not feasible and certainty of evidence will be assessed using the GRADE approach.

Systematic review registration number:
PROSPERO CRD42022338749
Online Robust Model Predictive Control Based Emergency Maneuvering System for Autonomous Vehicles
Authors: Bithar Vivek , Tulpule Punit , Midlam-Mohler Shawn 
Published: October 2022

Abstract
Nonlinear robust model predictive control (RMPC) provides a promising solution to the problem of automatic emergency maneuvering and it is capable of handling multiple, possibly conflicting objectives of robustness and performance. Even though RMPC gives a sub-optimal solution, the critical challenge in its real-time implementation is the high computational demand. This paper presents a real-time capable, robust tube MPC-based framework for steering control during emergency obstacle avoidance maneuvers. The novelty of this framework lies in the robust integration of path planning and path-following tasks of autonomous vehicles. A simulation study showcases the robust performance improvements of the proposed strategy over a non-robust MPC in different extreme maneuvering scenarios.
Wrist-Worn Accelerometry, Aging, and Gait Speed in the Baltimore Longitudinal Study of Aging
Authors: Wanigatunga Amal A. , Liu Fangyu , Urbanek Jacek K. , Wang Hang , Di Junrui , Zipunnikov Vadim , Cai Yurun , Dougherty Ryan J. , Simonsick Eleanor M. , Ferrucci Luigi , Schrack Jennifer A. 
Published: October 2022

Wrist-worn accelerometry metrics are not well defined in older adults. Accelerometry data from 720 participants (mean age 70 years, 55% women) were summarized into (a) total activity counts per day, (b) active minutes per day, (c) active bouts per day, and (d) activity fragmentation (the reciprocal of the mean active bout length). Linear regression and mixed-effects models were utilized to estimate associations between age and gait speed with wrist accelerometry. Activity counts per day, daily active minutes per day, and active bouts per day were negatively associated with age among all participants, while positive associations with activity fragmentation were only observed among those ≥65 years. More activity counts, more daily active minutes, and lower activity fragmentation were associated with faster gait speed. There were baseline age interactions with annual changes in total activity counts per day, active minutes per day, and activity fragmentation (Baseline age × Time, p < .01 for all). These results help define and characterize changes in wrist-based physical activity patterns among older adults.
Novel age constraints for the onset of the Steptoean Positive Isotopic Carbon Excursion (SPICE) and the late Cambrian time scale using high-precision U-Pb detrital zircon ages
Authors: Cothren Hannah R. , Farrell Thomas P. , Sundberg Frederick A. , Dehler Carol M. , Schmitz Mark D. 
Published: October 2022

AbstractThe Steptoean Positive Isotopic Carbon Excursion (SPICE) is a prominent +4–5‰ shift in the Cambrian δ13C record used for global chronostratigraphic correlation. The onset of this excursion is traditionally placed at the base of the Pterocephaliid trilobite biomere (base of the Furongian Series). Recent studies have documented local controls on the expression of the SPICE and emphasize the need for chronostratigraphic standards for these complex biogeochemical signals. We build upon prior work in western Laurentia by integrating δ13C and biostratigraphy with high-precision isotope dilution U-Pb detrital zircon maximum depositional ages that are coincident with the onset, peak, and falling limb of the SPICE. Our study provides the first useful numerical age constraint for the onset of the SPICE and the Laurentian trilobite biozones and requires revision of the late Cambrian geologic time scale boundaries by several million years.
Learning from healthcare workers’ experiences with personal protective equipment during the COVID-19 pandemic in Aotearoa/New Zealand: a thematic analysis and framework for future practice
Authors: Wild Cervantée E K , Wells Hailey , Coetzee Nicolene , Grant Cameron C , Sullivan Trudy A , Derraik José G B , Anderson Yvonne C 
Published: October 2022

ObjectivesSafety and welfare are critical as pandemic-related demands on the healthcare workforce continue. Access to personal protective equipment (PPE) has been a central concern of healthcare workers throughout the COVID-19 pandemic. Against the backdrop of an already strained healthcare system, our study aimed to explore the experiences of healthcare workers with PPE during the first COVID-19 surge (February–June 2020) in Aotearoa/New Zealand (NZ). We also aimed to use these findings to present a strengths-based framework for supporting healthcare workers moving forward.DesignWeb-based, anonymous survey including qualitative open-text questions. Questions were both closed and open text, and recruitment was multimodal. We undertook inductive thematic analysis of the dataset as a whole to explore prominent values related to healthcare workers’ experiences.SettingOctober–November 2020 in New Zealand.Participants1411 healthcare workers who used PPE during surge one of the COVID-19 pandemic.ResultsWe identified four interactive values as central to healthcare workers’ experiences: transparency, trust, safety and respect. When healthcare workers cited positive experiences, trust and safety were perceived as present, with a sense of inclusion in the process of stock allocation and effective communication with managers. When trust was low, with concerns over personal safety, poor communication and lack of transparency resulted in perceived lack of respect and distress among respondents. Our proposed framework presents key recommendations to support the health workforce in terms of communication relating to PPE supply and distribution built on those four values.ConclusionsHealthcare worker experiences with PPE access has been likened to ‘the canary in the coalmine’ for existing health system challenges that have been exacerbated during the COVID-19 pandemic. The four key values identified could be used to improve healthcare worker experience in the future.
Service discharges among US Army personnel with selected musculoskeletal and skin conditions: a retrospective cohort study
Authors: Nelson D Alan , Kaplan Robert M , Weisman Michael H , Kurina Lianne M 
Published: October 2022

ObjectivesTo determine the probability of discharge from military service among soldiers following an incident diagnosis of ankylosing spondylitis (AS), rheumatoid arthritis (RA), psoriasis or systemic lupus erythematous.MethodsAll soldiers on active duty in the US Army between January 2014 and June 2017 were included in a retrospective cohort analysis. Termination from service was ascertained using personnel records. Diagnostic codes were used to identify incident cases of the four musculoskeletal and skin diseases and, for comparison, diabetes mellitus (DM). Time to discharge was modelled using sex stratified multivariate survival analysis.ResultsThe analysis included 657 417 individuals with a total of 1.2 million person-years of observation. An elevated risk of discharge was observed in association with each of the five chronic conditions studied. The increase in adjusted risk of discharge was highest among soldiers with AS (men, HR=2.5, 95% CI 2.1 to 3.0; women, HR=2.1, 95% CI 1.4 to 3.2) and with DM (men, HR=2.4, 95% CI 2.2 to 2.7; women, HR=2.2, 95% CI 1.8 to 2.5), followed by those with RA (men, HR=1.8, 95% CI 1.5 to 2.2; women, HR=1.8, 95% CI 1.4 to 2.4).ConclusionsMilitary discharges are consequential for the service and the service member. The doubling in risk of discharge for those with AS or RA was comparable to that for personnel with DM. Conditions that affect the spine and peripheral joints may often be incompatible with military readiness. Nevertheless, a substantial fraction of service members with these diagnoses continued in service.
Protocol for the Endometriosis Research Queensland Study (ERQS): an integrated cohort study approach to improve diagnosis and stratify treatment
Authors: Tanaka Keisuke , Gilroy Deborah , Subramaniam Sugarniya , Lakshmi Preethi , Bhadravathi Lokeshappa Madhura , Wallace Leanne M , Atluri Sharat , Schmidt Bart , Ganter Peter , Baartz David , Smith Matthew , Mortlock Sally , Henders Anjali , Khalil Akram , Montgomery Grant , McKinnon Brett , Amoako Akwasi 
Published: October 2022

IntroductionEndometriosis is a common gynaecological disease associated with pelvic pain and subfertility. There are no non-invasive diagnostic tests, medical management requires suppression of oestrogens and surgical removal is associated with risk. Endometriosis is a complex genetic disease with variants in at least 27 genetic regions associated with susceptibility. Previous research has implicated a variety of biological mechanisms in multiple cell types. Endometrial and endometriotic epithelial cells acquire somatic mutations at frequency higher than expected in normal tissue. Stromal cells have altered adhesive capacity and immune cells show altered cytotoxicity. Understanding the functional consequences of these genetic variants on each cell type requires the collection of patient symptoms, clinical and genetic data and disease-relevant tissue in an integrated program.Methods and analysisThe aims of this study are to collect tissue associated with endometriosis, chart the genetic architecture related to endometriosis in this tissue, isolate and propagate patient-specific cellular models, understand the functional consequence of these genetic variants and how they interact with environmental factors in pathogenesis and treatment response.We will collect patient information from online questionnaires prior to surgery and at 6 and 12 months postsurgery. Treating physicians will document detailed surgical data. During surgery, we will collect blood, peritoneal fluid, endometrium and endometriotic tissue. Tissue will be used to isolate and propagate in vitro models of individual cells. Genome wide genotyping and gene expression data will be generated. Somatic mutations will be identified via whole genome sequencing.Ethics and disseminationThe study has been approved and will be monitored by the Metro North Human Research Ethics committee (HREC) and research activities at the University of Queensland (UQ) will be overseen by the UQ HREC with annual reports submitted. Research results will be published in peer-reviewed journals and presented at conferences were appropriate. This study involves human participants and was approved by RBWH Human Research Ethics Committee; HREC/2019/QRBW/56763.The University of Queensland; 2017002744. Participants gave informed consent to participate in the study before taking part.
Preferences of people with mild cognitive impairment for physical activity interventions in China: protocol for a discrete choice experiment study
Authors: Liu Chang , Yang Hong , Jiao Yuchen , Liu Yunyue , Chang Jing , Ji Yan 
Published: October 2022

IntroductionExercise interventions are important non-pharmacological interventions for patients with mild cognitive impairment (MCI), but patients with MCI have poor compliance and there is no consistent strategy for exercise interventions. Understanding the needs and preferences of MCI patients allows for the development of effective and acceptable exercise intervention programmes that achieve the goals of patient-centred care. This study uses a discrete choice experiment (DCE) to measure and quantify MCI patients’ preferences for exercise interventions, and aims at (1) identifying and exploring which elements of exercise intervention programmes are essential for MCI patients; (2) measuring MCI patients’ preferences for exercise interventions and summarising relevant characteristics that may influence preference choices and (3) determining whether these preferences vary by participant characteristics and classifying the population types based on the sociodemographic characteristics of the participants.Methods and analysisA DCE will be conducted to explore MCI patients’ preferences for exercise interventions. We conducted a systematic literature review and extensive qualitative work to select the best attributes to develop the design of DCE. A partial factorial survey design was generated through an orthogonal experimental design. We will conduct a questionnaire survey in one city each in the eastern (Nanjing), western (Xining), southern (Zhuhai) and northern (Beijing) parts of China and reach the planned sample size (n=278). Final data will be analysed using a mixed logit model and a latent class model.Ethics and disseminationThis study was approved by the Ethics Committee of Nanjing Medical University (2021-666). All participants will be required to provide informed consent. Our findings will be disseminated and shared with interested patient groups and the general public through online blogs, policy briefs, national and international conferences and peer-reviewed journals.
Measuring psychological safety and local learning to enable high reliability organisational change
Authors: Cartland Jenifer , Green Michaeleen , Kamm Desty , Halfer Diana , Brisk Mary Alida , Wheeler Derek 
Published: October 2022

The ability to measure the extent to which an organisation is highly reliable, or the extent to which reliability may change over time, has not kept up with the development of theory. The paper examines aspects of workplace culture, employee motivation and leadership behaviours that support continuous learning and improvement in an effort to measure the transition to high reliability.To evaluate the effectiveness of its high reliability initiative, one children’s hospital sought to build measures that would provide an assessment of progressive movement towards a ‘culture of safety’, and track the success over time. This paper reports on the development of two scales (trust in team members and trust in leadership) that are intended to measure two cultural conditions fostered by the five high reliability principles and a composite measure on local learning activities. The two scales are strongly associated with local learning activities in employees’ work areas and with employees’ willingness to participate in extra role activities. We suggest that they are foundational to creating a psychologically safe environment and thus to becoming a high reliability organisation.
Predictive models for musculoskeletal injury risk: why statistical approach makes all the difference
Authors: Rhon Daniel I , Teyhen Deydre S , Collins Gary S , Bullock Garrett S 
Published: October 2022

ObjectiveCompare performance between an injury prediction model categorising predictors and one that did not and compare a selection of predictors based on univariate significance versus assessing non-linear relationships.MethodsValidation and replication of a previously developed injury prediction model in a cohort of 1466 service members followed for 1 year after physical performance, medical history and sociodemographic variables were collected. The original model dichotomised 11 predictors. The second model (M2) kept predictors continuous but assumed linearity and the third model (M3) conducted non-linear transformations. The fourth model (M4) chose predictors the proper way (clinical reasoning and supporting evidence). Model performance was assessed with R2, calibration in the large, calibration slope and discrimination. Decision curve analyses were performed with risk thresholds from 0.25 to 0.50.Results478 personnel sustained an injury. The original model demonstrated poorer R2(original:0.07; M2:0.63; M3:0.64; M4:0.08), calibration in the large (original:−0.11 (95% CI −0.22 to 0.00); M2: −0.02 (95% CI −0.17 to 0.13); M3:0.03 (95% CI −0.13 to 0.19); M4: −0.13 (95% CI −0.25 to –0.01)), calibration slope (original:0.84 (95% CI 0.61 to 1.07); M2:0.97 (95% CI 0.86 to 1.08); M3:0.90 (95% CI 0.75 to 1.05); M4: 081 (95% CI 0.59 to 1.03) and discrimination (original:0.63 (95% CI 0.60 to 0.66); M2:0.90 (95% CI 0.88 to 0.92); M3:0.90 (95% CI 0.88 to 0.92); M4: 0.63 (95% CI 0.60 to 0.66)). At 0.25 injury risk, M2 and M3 demonstrated a 0.43 net benefit improvement. At 0.50 injury risk, M2 and M3 demonstrated a 0.33 net benefit improvement compared with the original model.ConclusionModel performance was substantially worse in the models with dichotomised variables. This highlights the need to follow established recommendations when developing prediction models.