bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longterm physicochemical stability of ready-to-administer human insulin injection solutions 1 I.U./mL in 50 mL plastic syringes
Authors: Erdnüß Frank , Mohr André , Krämer Irene 
Published: March 2022

Abstract

Objectives
The objective of this study was to investigate the physicochemical stability of ready-to-adminster human insulin (HI) 1 I.U./mL injection solutions of two different brand products diluted with 0.9% NaCl solution under different storage conditions either in 50 mL disposable plastic syringes or as bulk solution in infusion bags.

Methods
HI test solutions 1 I.U./mL were prepared with Huminsulin® Normal 100 and Actrapid® Penfill®, diluted with 0.9% sodium chloride infusion solution, and filled in Original-Perfusor® syringes or BD® Perfusion syringes. Test solutions were stored for 90 days at 2–8 °C/dark or at 20–25 °C/diffuse room light. Bulk solutions 1 I.U./mL prepared with Huminsulin® Normal 100 were stored in two different 3 L infusion bags (Ecobag® click and ExactaMix® EVA bag) at 2–8 °C/dark for five days. HI concentrations were determined by reversed-phase high-performance liquid chromatography at predefined time points. Beside regular visual inspection, subvisible particles and pH values were measured.

Results
Ready-to-adminster Huminsulin® Normal and Actrapid® Penfill® injection solutions 1 I.U./mL prepared in 50 mL Original-Perfusor® syringes or BD® Perfusion syringes remained physicochemically stable for up to 90 days when stored at 2–8 °C/dark and for at least 14 days when kept at 20–25 °C/diffuse room light. Prefilled 3 L polyolefin infusion bags (Ecobag® click) are suitable for the preparation of Huminsulin® 1 I.U./mL bulk solutions. In ethylene vinyl acetate (EVA) bags, HI concentrations decreased rapidly.

Conclusions
Ready-to-administer Huminsulin® Normal and Actrapid® Penfill® injection solutions 1 I.U./mL can be prepared in advance by dilution with 0.9% sodium chloride infusion solution and filled into 50 mL Original-Perfusor® syringes or BD® Perfusion syringes; subsequent storage at 2–8 °C/dark is possible for up to 90 days. For preparation of bulk solutions, the prefilled polyolefin infusion bag is appropriate.
Experimental investigations of a novel pressure microfoam preparation device for dust removal
Authors: Li Yonghe , Wang Qingguo , Tuo Lina , Zhang Fasong , Zhang Xiaoyu 
Published: March 2022

Abstract
Compared with large size foam, pressure microfoam has the characteristics of a good pipeline transportation stability, good jet orientation, strong impact force, and strong ability to capture fine dust, which is more suitable for dust removal. The traditional foam preparation device has the disadvantages of high-pressure loss, poor foaming effect, and foam uniformity. To overcome the above shortcomings, the annular air supply vertical foam preparation device was proposed in the article. The foaming cylinder of the device adopts a vertical design to avoid the influence of uneven distribution of foam caused by gravity; the spiral nozzle is used to evenly spray the foaming liquid on the foaming mesh to increase the contact area between foam and airflow. The stainless steel wire mesh and cotton wire mesh are adopted to improve the reliability and durability of concave foaming mesh. The performance of the new device was obtained by the self-built experimental system. Finally, the field test shows that the conditions of the heading face could fully meet the requirements of the device for pressure water and compressed air, and the produced pressure microfoam can effectively control dust.
Crystallisation of phosphates revisited: a multi-step formation process for SrHPO4
Authors: Ruiz Arana Laura , Ströh Jonas , Amtsfeld Jasper , Doungmo Giscard , Novikov Dmitri , Khadiev Azat , Etter Martin , Wharmby Michael , Suta Markus , Terraschke Huayna 
Published: March 2022

Abstract
SrHPO4 is used in a multitude of applications, including biomedicine, catalysts, luminescent materials, and batteries. However, the performance of these materials depends on the ability to control the formation and transformation of strontium phosphates. This work focuses on the application of in situ and ex situ measurements, including synchrotron-based X-ray diffraction (XRD) analysis, luminescence of Ce3+ and Eu3+ dopants, light transmission, reflectance, and thermogravimetry to track structural changes in SrHPO4 under different experimental conditions. Ex situ analysis of aliquots revealed favourable crystallisation of β-SrHPO4 through the formation of Sr6H3(PO4)5·2H2O as an intermediate. Furthermore, in situ analysis showed that the reaction mechanism evolves via the initial formation of amorphous strontium phosphate and Sr5(PO4)3OH, which subsequently transforms to γ-SrHPO4. Analysis of the luminescence properties of the lanthanide dopants provided insights into the coordination environments of the substituted Sr2+ sites.
Occurrence of Z-2-oxo-4-methyl-3-pentene-1,5-dioic acid and its regioisomer 4-methylene-2-oxo-glutaric acid in tulip tissues
Authors: Kato Yasuo , Nomura Taiji 
Published: March 2022

Abstract
Although Z-2-oxo-4-methyl-3-pentene-1,5-dioic acid (Z-OMPD) has been identified as a major dicarboxylic acid in tulip tissues, its biosynthetic pathway has not been elucidated. Herein, Z-OMPD was isolated from tulip leaves and chemically synthesized. Comparisons of these samples revealed that Z-OMPD exists as a tautomeric mixture at physiological pH. As a regioisomer of Z-OMPD, we enzymatically and chemically prepared 4-methylene-2-oxo-glutaric acid (4-MEOG) for the first time. Using these compounds as standards, the occurrence of Z-OMPD and 4-MEOG in various tissues of the tulip cultivar “Murasakizuisho” was evaluated directly and by 2,4-dinitrophenylhydrazone derivatization. Z-OMPD was found to be abundant in the aerial tissues, whereas 4-MEOG was almost absent from all tissues. Stability analyses of Z-OMPD and 4-MEOG revealed that no double bond isomerization occurred at physiological pH, suggesting that enzyme systems are responsible for Z-OMPD biosynthesis in tulip tissues.
Influence of Subgrade Freezing and Thawing on Vertical Deformation of Asphalt Pavement
Authors: Duojie Cidan , Zhao Pinxue , Hu Yongping , Zhang Hongfei , Si Wei , Ma Biao 
Published: March 2022

Abstract
The severe freezing and thawing in seasonally frozen soils is one of the main reasons for frost heave and thaw settlement of subgrade, which leads to cracks and other serious diseases of asphalt pavement. To study the impact of freezing and thawing of subgrades on the pavement structure, an on-site investigation of the asphalt pavement diseases in Tibet, China was conducted, and a 1:5 mock-up for laboratory tests and a finite element model were designed. The temperature and humidity of the subgrade and the stress and vertical deformation of the pavement were analyzed. It was found that the moisture content of the subgrade had a significant impact on the cracking of asphalt pavement, and the vertical displacement of pavement increased by about 0.6 mm when the moisture content increased by 5 %. If there were initial cracks in the semirigid base, the maximum principal stress of the asphalt surface layer was 2.1 times more than that without cracks, which could easily lead to serious diseases in asphalt pavement. The flexible base had a good deformation coordination, which reduced the damage of the frost heave to the asphalt pavement, thereby preventing cracks on the asphalt pavement. The research results provided a theoretical direction for the analysis of frost heave characteristics and a basis for the optimum design of pavement structures in cold regions.
Outcomes in growth hormone-treated Noonan syndrome children: impact of PTPN11 mutation status
Authors: Jorge Alexander A L , Edouard Thomas , Maghnie Mohamad , Pietropoli Alberto , Kelepouris Nicky , Romano Alicia , Zenker Martin , Horikawa Reiko 
Published: March 2022

Introduction
Mutations in PTPN11 are associated with Noonan syndrome (NS). Although the effectiveness of growth hormone therapy (GHT) in treating short stature due to NS has been previously demonstrated, the effect of PTPN11 mutation status on the long-term outcomes of GHT remains to be elucidated.

Methods
This analysis included pooled data from the observational American Norditropin Studies: Web-Enabled Research Program (NCT01009905) and the randomized, double-blinded GHLIQUID-4020 clinical trial (NCT01927861). Pediatric patients with clinically diagnosed NS and confirmed PTPN11mutation status were eligible for inclusion. The effectiveness analysis included patients who were GHT-naïve and pre-pubertal at GHT start. Growth outcomes and safety were assessed over 4 years of GHT (Norditropin®, Novo Nordisk A/S).

Results
A total of 69 patients were included in the effectiveness analysis (71% PTPN11 positive). The proportion of females was 32.7 and 30.0% in PTPN11-positive and negative patients, respectively, and mean age at GHT start was 6.4 years in both groups. Using general population reference data, after 4 years of GHT, the mean (s.d.) height SD score (HSDS) was −1.9 (1.1) and −1.7 (0.8) for PTPN11-positive and PTPN11-negative patients, respectively, with no statistical difference observed between groups. The mean (s.d.) change in HSDS at 4 years was +1.3 (0.8) in PTPN11-positive patients and +1.5 (0.7) in PTPN11-negative patients (no significant differences between groups). Safety findings were consistent with previous analyses.

Conclusions
GHT resulted in improved growth outcomes over 4 years in GHT-naïve, pre-pubertal NS patients, irrespective of PTPN11 mutation status.
Memahami Teks, Melahirkan Konteks: Menelisik Interpretasi Ideologis Jamaah Tabligh
Authors: Junaedi Didi 
Published: March 2022

The dialectical process between the Qur’an, Hadith and other religious texts with reality will produce a variety of interpretations. This diversity of interpretations within different kinds of approaches: theological, legal, mystical, social, political, economical as well as various other points, in turn will present a discourse in the domain of thought, as well as practical measures in social realities. In this article, the author analyzes the theological and legal interpretation of Jama‘ah Tabligh. He also discusses a number of concepts which was arisen from their readings of a number of verses in the Qur’an and Hadith.
Memahami al-Qur’an dengan Kearifan Lokal: Nuansa Budaya Sunda dalam Tafsir al-Qur’an berbahasa Sunda
Authors: Rohmana Jajang A 
Published: March 2022

The local interpretation of the Qur’an cannot be ignored in the discourse of Qur’anic studies in Indonesia. Its significance lays not only in the continuity of Islamic tradition networks, but also in the creativity of linguistic expression and its content of local wisdom relevant with the need of society. This study tries to shed light on the Sundanese cultural nuance in Sundanese Qur’anic interpretation. There are at least three elements which indicate Sundanese cultural nuance which becomes the characteristic of local reception of the Qur’an in Sundanese Qur’anic interpretation: the use of speech level, traditional expression and the metaphore of Sundanese nature. These three elements can be used as the first categorization to classify Sundanese Qur’anic interpretation as Sundanese.
Penggunaan Metode Content Analysis dalam Penelitian Hadis
Authors: Rahman Andi 
Published: March 2022

To determine the authenticity of hadith, we need to analyze its chain of transmission and its content. The analysis of the chain of transmission is conducted through the data collection in the literature of tarajum al-ruwat, by analyzing the concept used in sanad criticism. Among the critique of hadith, some scholars used a concept generally used by others, but they understand it differently. Others use special concept not usually used by others, without explaining what they mean by that concept. There are also others who explain the biography of the hadith transmitters, without explaining their qualities, Al-Bukhari (d. 265 H) is among the ciritique of hadith who use these three concepts. This article, using content analysis methodology, tries to analyze and understand these three concepts.
Paradigma Sintesis Tafsir Teks Al-Qur’an Menimbang Hermeneutika Pemaknaan Teks Jorge J.E Gracia Sebagai Teori Penafsiran Tekstual al-Qur’an
Authors: Wathani Syamsul 
Published: March 2022

Artikel ini membahas konsep hermeneutika pemaknaan teks Jorge J.E Gracia sebagai teori penafsiran tekstual al-Qur’an, dengan tiga poin pokok bahasan: (i) narasi tekstualitas al-Qur’an sebagai obyek penafsiran (ii) hermeneutika teks Jorge J.E Gracia dan (iii) paradigma tafsir tekstual terhadap al-Qur’an. Pola kajian artikel ini diarahkan pada analisis interpretatif-strukturasi, dengan melakukan analisis isi (content analysis) pada karya utama tokoh. Artikel ini menemukan bahwa: (1) Konsep teks al-Qur’an atau al-Naṣṣ adalah kesadaran utama, sebab al-Qur’an adalah sesuatu terbaca/tersentuh (al-Maktūb), ia memiliki entitas hurf, al-Qur’an, al-kitab, ayat, kalimat dan al-risalah. (2) Nalar hermeneutis pemaknaan teks ala Gracia mengurai kesalahpahaman (misunderstanding) teks, dengan metode the development of textual interpretation, untuk menjembatani kesejarahan teks dengan keadaan audiens. (3) Paradigma tafsir tekstual dengan konsep “al-nash” bekerja dengan menekankan pada adanya pemahaman yang baik atas teks, audiens, konteks, karena teks al-Qur’an itu tidak sebatas tertulis dalam sebuah bentuk (form), ia begitu kompleks, ia sebuah konstruksi (construction), kombinasi (combination) dan korelasi (correlation).
The Qur’ān and Woman’s Leadership Discourse in Indonesia: Modern Interpretation of QS. 4: 34
Authors: Kusmana Kusmana 
Published: March 2022

The interpretation of QS. 4: 34 gains a new popularity in modern era as it has been used and abused as one of the references in discussing gender discourse in Islam. The paper discusses it in relation to woman’s leadership in modern Indonesian context. Hard-liners’ perceptions such as that of Salafi’s interpretation is excluded in this discussion. It deserves another adequate discussion. The paper also restricts its discussion to the thoughts of Hamka, M. Quraish Shihab, Husein Muhammad, and of Ministry of Religious Affairs’ interpretation and treats them as exemplary of what is going on in the field of Qur’anic interpretation in this context. Using a descriptive-analytic method, this study deploys a library review technique in answering its question of the study, “how modern Muslim Indonesian scholars interpret the QS. 4: 34 in the context of democracy of Indonesia? The study concludes that they in deciphering the verse tend to adapt the demand of democracy but with a careful maintenance of the traditional wisdom.
Orientalist Criticism of the Hadith (Tracing Theory “The Spread of Isnad” Michael Allan Cook)
Authors: Zuhri LL Saefudin 
Published: March 2022

Michael Cook sebagai seorang ilmuwan kelas dunia. Ia adalah seorang sejarawan berkebangsaan Inggris-Scotlandia. Selain menjadi pesohor, Cook juga seorang sarjana Sejarah Islam, maka dari itu, ia juga dikenal sebagai salah satu sejarawan Inggris yang mahsyur di kalangan orientalis yang fokus mengkaji tentang keislaman. Artikel ini mencoba untuk menganalisis ide-ide Cook tentang tautan umum dan proses teori penyebaran aplikasi isnad dalam fenomena Kritik sanad Yang selalu menjadi perdebadatan dikalangan para pengkaji hadist adalah Keaslian sanad. Hal Ini terkait erat dengan fenomena "Common Link" yang banyak Cendekiawan Barat mengkaji tentang Hadis terkait dengan penelitian mereka . Dari Fenomena tersebut, ini menarik untuk dikaji. Berdasarkan hasil dari kajian penelitian ini, Cook membawa sudut pandang berbeda dalam fenomena Common Link yang dituangkan pada kritiknya terhadap teori Schachtian. Untuk Cook, ada dua poin penting yang terkait dengan Common Link. Pertama, Tautan Umum tidak bisa dibenarkan sebagai pemalsu hadis. Itu karena Common Link ke beberapa exctent adalah karya teknik dari narator lain (periwayat). Kedua, Common Link tidak dapat menjadi dasar penanggalan hadis.
Beberapa Isu Teologi dan Syari’ah dalam Perspektif Islam dan Agama Samawi Lainnya: Studi Kasus Pemikiran M. Quraish Shihab
Authors: Abidin Ahmad Zainal , Aziz Thoriqul , Chayati Dewi Charisun 
Published: March 2022

This article discusses the comparison of Islamic perspective and other religious perspectives regarding some theological and sharia issues, taking Quraish Shihab’s thought as a case in point. Using a descriptive-analytic method, this study answers how his thoughts about some issues of theology and shari’a are similar with or different from other religious perspectives. This article finds that the theological and sharia themes that are carried by M. Quraish Shihab are related to texts such as in other religions, especially through the theme of unifying God, respecting for others, establishing prayer, prohibition of killing and doing heinous, qishāsh law, fasting, spirituality, and alms. Intertextual thinking is useful for bringing together interfaith themes that emphasize the unity of sources and the close relation of religions to one another.
Profitabilitas pada perbankan syariah di Indonesia: Studi pengaruh faktor internal dan eksternal
Authors: Fadila Indri Yaumil , Hermawan Dadang 
Published: March 2022

The purpose of this study is to find out and analyze internal factors and external factors of Islamic banking that can affect the profitability of Islamic Banking both simultaneously and partially. The dependent variable used in this study is incomesmoothing which is proxied by Profitability which is proxied by the Return On Assets (ROA), while the independent variables in this study are Capital Adequacy proxied by the Capital Adequacy Ratio (CAR), Finance Risk proxied by Non Performing Finance (NPF), Inflation, and BI Rate. This research was conducted at Sharia Commercial Banks in Indonesia for the period 2015. The population in this study is Islamic banking in Indonesia and the sample used is Sharia Commercial Banks in Indonesia, which until 2019 amounted to 14 banks. The type of data used is secondary data that is data from the been published by Otoritas Jasa Keuangan. The type of data used is secondary data obtained from twww.ojk.com and www.bi.go.id. The analysis technique used in this study is Multiple Regression analysis using the SPSS 22 program tool.Kata kunci: Capital Adequacy Ratio, Non Perfoming Finance, Return On Asset, Inflation BI rate
Ibn al-Khaṭīb: Character Assassin
Authors: Abdelkarim Sherif 
Published: March 2022

AbstractAmong the poetic modes to persist since Islam's advent,hijāʾ, or classical Arabic invective poetry, pushes the limits of permissible art while preserving aspects of court culture not found elsewhere in the premodern corpus. The harshest pieces ofhijāʾhave jeopardized its very status as a proper art form, its popular appeal notwithstanding. This essay sketches the ethical and aesthetic contours ofhijāʾin postclassical Arabic literature (ca. 1000–1400), including the motivations that occasioned it. It offers as a case study thehijāʾof the foremost Andalusian minister, Lisān al-Dīn ibn al-Khat.īb (d. 1375). The poet-politician's terms of abuse shed light on Granada's political strains, and they jar with a tradition that proscribes calumny altogether and calls adherents to unite in virtue and piety, not sin and slander. In practice, Ibn al-Khat.īb's sharp tongue invited physical retaliation, which forced the man to scope the lands, in search of escape.
Resentment: Shakespeare and Nietzsche on Anger without Privilege
Authors: Robinson Benedict S. 
Published: March 2022

AbstractThis essay traces the literary and cultural history of resentment from the word's first arrival in English. It argues that resentment harbors the seeds of a new paradigm of anger, tied to a new sense of anger's social content: where ancient accounts of anger center on the anger of the powerful, this form of anger—embodied most famously in Nietzsche's theory ofRessentiment—addresses the anger of disempowered social agents. The argument unfolds in three stages: first, I use digital tools and a large-scale archive to analyze what early modern writers wrote about when they wrote about resentment; second, I pursue the word into the history of science and new ways of thinking about the nature of anger; and third, I read literary history and the Shakespearean plot of tragic intrigue in particular as an extended imaginative investigation of this changing set of concerns in the sociality of anger.
Risk Factors Associated with Severe Disease in COVID-19
Authors: ÇÖLKESEN Fatma , EROĞLU Esma , AYDIN Tevhid , TARAKÇI Arzu , ÖZDEMİR ARMAĞAN Şule , ÇIĞCI Mihriban , KACAR Fatma 
Published: March 2022

Aim: The aim of this study was to determine the characteristics and risk factors associated with severe disease in COVID-19.
Materials and Methods: A total of 186 adult patients (97 female) hospitalized with a diagnosis of COVID-19 (laboratory-confirmed cases, SARS-CoV-2-RNA detected with the molecular method) between March 2020-May 2020 were included in the study. The possible risk factors evaluated were age, gender, comorbidities, smoking, symptoms, and laboratory parameters at the time of admission to the hospital.
Results: The patients comprised 97 (52.2%) females, evaluated as severe COVID-19 in 43 (23.1%) cases and non-severe COVID-19 in 143 (76.9%) cases. Multivariate logistic regression analysis identified risk factors for severe COVID-19 to be age >65 years (odds ratio (OR)=5.289, 95% confidence interval (CI):1.680-16.651, p:0.004), and elevated levels of LDH (OR=8.521, 95% CI:2.445-29.702, p:0.001), ferritin (OR=7.436, 95% CI:2.171-25.468, p:0.001), D-dimer (OR=10.076, 95% CI: 2.758-36.813, p65 years, and elevated LDH, ferritin, D-dimer, CK-MB, and troponin levels are independent risk factors. Clinicians should consider these potential risk factors for progression to severe disease when treating COVID-19 patients.
INVESTIGATING THE RELATIONSHIP BETWEEN INSULIN PERCEPTIONS AND DIABETES SELF-MANAGEMENT OF INTENSIVE CARE PATIENTS WITH TYPE 2 DIABETES
Authors: GÜNAY İSMAİLOĞLU Elif , TİMUÇİN Serkan 
Published: March 2022

Aim: This study aimed to determine the level of perception of insulin and diabetes symptom management of patients with Type 2 diabetes who received inpatient treatment in intensive care.
Materials and Methods: This study was conducted in the Internal Medicine and Anesthesia Intensive Care units of a state hospital during the period of December 01, 2020 and March 31, 2021. The sample of the study was composed of 100 voluntary patients who used insulin. Research data were collected via the Patient Introduction Form, Diabetes Self-Management Questionnaire and the Insulin Treatment Appraisal Scale. Written permission was obtained from ethics committee and patients.
Results: The average age of the patients was 44.57 ± 14.8, 52% were female, 72% were single, 47% were primary school graduates, and 52% had a chronic complication related to diabetes. The mean time duration for being diagnosed with diabetes was 20.59 ± 12.87 years (3-52) while the mean duration of insulin use was 2.8 ± 1.17 years. Patients’ ITAS positive and negative item subscale mean scores were 11.44 ± 3.43 and 48.18 ± 12.09, respectively. Patients’ mean Diabetes Self-Management Questionnaire total score was 4.07 ± 1.74 (range: 0.62-8.75).
Conclusion: Patients have a high negative perception towards insulin use and their diabetes self-management is below the average. There was a high level of negative correlation between patients’ negative insulin perception and glucose management and diet control sub-dimensions of their diabetes self-management.