bluuebunny/crossref_metadata_2025_split huggingface dataset:
Third COVID-19 vaccine dose boosts neutralizing antibodies in poor responders
Authors: Lake Douglas F. , Roeder Alexa J. , Gonzalez-Moa Maria J. , Koehler Megan , Kaleta Erin , Jasbi Paniz , Vanderhoof John , McKechnie Davis , Forman Jack , Edwards Baylee A. , Seit-Nebi Alim , Svarovsky Sergei 
Published: July 2022

Abstract
Background
While evaluating COVID-19 vaccine responses using a rapid neutralizing antibody (NAb) test, we observed that 25% of mRNA vaccine recipients did not neutralize >50%. We termed this group “vaccine poor responders” (VPRs). The objective of this study was to determine if individuals who neutralized <50% would remain VPRs, or if a third dose would elicit high levels of NAbs.

Methods
269 healthy individuals ranging in age from 19 to 80 (Average age = 51; 165 females and 104 males) who received either BNT162b2 (Pfizer) or mRNA-1273 (Moderna) vaccines were evaluated. NAb levels were measured: (i) 2–4 weeks after a second vaccine dose, (ii) 2–4 months after the second dose, (iii) within 1–2 weeks prior to a third dose and (iv) 2–4 weeks after a third mRNA vaccine dose.

Results
Analysis of vaccine recipients reveals that 25% did not neutralize above 50% (Median neutralization = 21%, titers <1:80) within a month after their second dose. Twenty-three of these VPRs obtained a third dose of either BNT162b2 or mRNA-1273 vaccine 1–8 months (average = 5 months) after their second dose. Within a month after their third dose, VPRs show an average 5.4-fold increase in NAb levels (range: 46–99%).

Conclusions
The results suggest that VPRs are not permanently poor responders; they can generate high NAb levels with an additional vaccine dose. Although it is not known what levels of NAbs protect from infection or disease, those in high-risk professions may wish to keep peripheral NAb levels high, limiting infection, and potential transmission.
Moving direction‐based adaptive task migration in MEC
Authors: Li Yang , Wei Ziling , Su Jinshu 
Published: July 2022

AbstractEdge computing is expected to be a promising paradigm to provide low‐latency services. Tasks from resource‐limited users can be offloaded to edge servers for efficient execution within a limit time. This innovative technique has attracted widespread attention. Task migration is one of the important problems in mobile edge computing (MEC). Taking vehicle network as an example, during the moving process, a vehicle passes through multiple edge servers and decisions about where to migrate the task need to be made. The moving direction should be emphasized since it directly determines a vehicle's trajectory. Nevertheless, few existing works take the moving direction into consideration. In this paper, task migration issue during the vehicle's mobility process is investigated and the moving direction is specifically considered. The direction helps exclude meaningless selections. The moving process can be formulated as a Markov decision process (MDP) and effort is made to design an adaptive algorithm with direction consideration, aiming at minimizing the total communication time while satisfying the deadline of each task. Based on deep Q network (DQN), we devise a Soft update and parameter Noise applied algorithm DQN‐SN, trying to enlarge action exploration space and stabilize the target network's parameter placement in training process. Besides, with the goal of building credible MEC, a credit‐based scheme is also introduced to establish a trusted edge environment. Extensive experiments are conducted to evaluate the performance of our proposed algorithm. Compared to Greedy algorithm and DQN, the total consumed task communication time of DQN‐SN shows 10–20% reduction. Furthermore, the algorithms with the direction factor always outperform the algorithms without direction consideration.
Highly efficient and wide input range maximum power point tracking circuit with coarse and fine stages for energy harvesting systems
Authors: Dang Van‐Thai , Han Jae‐Soub , Shim Yong , Baek Kwang‐Hyun 
Published: July 2022

AbstractThis letter presents a highly efficient and wide input range maximum power point tracking (MPPT) circuit for energy harvesting systems (EHSs). The conventional MPPT circuit shows attenuation of the power conversion efficiency (PCE) at low input voltages due to insufficient distribution of conversion ratio (CR) in switched capacitor (SC) dc–dc converters. To overcome this critical issue, the proposed circuit implements coarse and fine stages to increase the number of CR. The proposed MPPT operation can be accurately achieved with CR tuning only (without switching frequencies), which results in high PCE. This work is fabricated in the 180‐nm CMOS process and measured with the commercial photovoltaic (PV) cells to demonstrate the advantages of the proposed circuit. The measurement results show that the EHS achieves a flat and improved PCE over a wide input range of 0.4 to 1.6 V. The PCE is as high as 88% for an output power below 50 μW and the active area occupies 1.2 mm2.
Lithium depletion boundary, stellar associations, andGaia
Authors: Galindo-Guil F. J. , Barrado D. , Bouy H. , Olivares J. , Bayo A. , Morales-Calderón M. , Huélamo N. , Sarro L. M. , Rivière-Marichalar P. , Stoev H. , Montesinos B. , Stauffer J. R. 
Published: July 2022

Context.Stellar ages are key to improving our understanding of different astrophysical phenomena. However, many techniques to estimate stellar ages are highly model-dependent. The lithium depletion boundary (LDB), based on the presence or absence of lithium in low-mass stars, can be used to derive ages in stellar associations of between 20 and 500 Ma.Aims.The purpose of this work is to revise former LDB ages in stellar associations in a consistent way, taking advantage of the homogeneousGaiaparallaxes as well as bolometric luminosity estimations that do not rely on monochromatic bolometric corrections.Methods.We studied nine open clusters and three moving groups characterised by a previous determination of the LDB age. We gathered all the available information from our data and the literature: membership, distances, photometric data, reddening, metallicity, and surface gravity. We re-assigned membership and calculated bolometric luminosities and effective temperatures using distances derived fromGaiaDR2 and multi-wavelength photometry for individual objects around the former LDB. We located the LDB using a homogeneous method for all the stellar associations. Finally, we estimated the age by comparing it with different evolutionary models.Results.We located the LDB for the twelve stellar associations and derived their ages using several theoretical evolutionary models. We compared the LDB ages among them, along with data obtained with other techniques, such as isochrone fitting, ultimately finding some discrepancies among the various approaches. Finally, we remark that the 32 Ori MG is likely to be composed of at least two populations of different ages.
GaiaData Release 3
Authors: Evans D. W. , Eyer L. , Busso G. , Riello M. , De Angeli F. , Burgess P. W. , Audard M. , Clementini G. , Garofalo A. , Holl B. , Jevardat de Fombelle G. , Lanzafame A. C. , Lecoeur-Taibi I. , Mowlavi N. , Nienartowicz K. , Palaversa L. , Rimoldini L. 
Published: July 2022

Context.As part ofGaiaData Release 3 (GaiaDR3), epoch photometry has been released for 1.2 million sources centred on M 31. This is a taster forGaiaData Release 4 where all the epoch photometry will be released.Aims.In this paper, the content of theGaiaAndromeda Photometric Survey (GAPS) is described, including statistics to assess the quality of the data. Known issues with the photometry are also outlined.Methods.Methods are given to improve interpretation of the photometry, in particular, a method for error renormalisation. Also, use of correlations between the three photometric passbands allows clearer identification of variables, and is not affected by false detections caused by systematic effects.Results.GAPS presents a unique opportunity to look atGaiaepoch photometry that has not been preselected based on variability. This allows investigations to be carried out that can be applied to the rest of the sky using the mean source results. Additionally, scientific studies of variability can be carried out on M 31 and the Milky Way in general.
Comorbidities in Mild Autonomous Cortisol Secretion – A
Clinical Review of Literature
Authors: Czapla-Iskrzycka Aleksandra , Świątkowska-Stodulska Renata , Sworczak Krzysztof 
Published: July 2022

AbstractMild autonomous cortisol secretion (mACS) is a state of cortisol excess usually
associated with existence of adrenal incidentaloma. Because of the lack of
symptoms of the disease, the biochemical evaluation is the most important to
determine a diagnosis. However, scientific societies have different diagnostic
criteria for mACS, which makes the treatment of this disease and using results
of original papers in daily practice more difficult. Chronic hypercortisolemic
state, even if mild, may lead to diseases that are mostly connected with overt
Cushing’s syndrome. Some of them can cause a higher mortality of
patients with mACS and those problems need to be addressed. In this review we
describe the comorbidities associated with mACS: cardiovascular disorders,
arterial hypertension, diabetes mellitus, insulin resistance, dyslipidemia,
obesity, metabolic syndrome, non-alcoholic fatty liver disease, vertebral
fractures and osteoporosis. The point of this paper is to characterise them and
determine if and how these conditions should be managed. Two databases –
PubMed and Web of Science were searched. Even though the evidence are scarce,
this is an attempt to lead clinicians through the problems associated with this
enigmatic condition.
Recent Applications on Dual-Catalysis for C–C and C–X Cross-Coupling Reactions
Authors: Ravi Kishore Dakoju , Sreenivasulu Chinnabattigalla , Satyanarayana Gedu , Dapkekar Anil Balajirao 
Published: July 2022

AbstractCoupling reactions stand amid the most significant reactions in synthetic organic chemistry. Of late, these coupling strategies are being viewed as a versatile synthetic tool for a wide range of organic transformations in many sectors of chemistry, ranging from indispensable synthetic scaffolds and natural products of biological significance to novel organic materials. Further, the use of dual-catalysis in accomplishing various interesting cross-coupling transformations is an emerging field in synthetic organic chemistry, owing to their high catalytic performance rather than the use of a single catalyst. In recent years, synthetic organic chemists have given considerable attention to hetero-dual catalysis; wherein these catalytic systems have been employed for the construction of versatile carbon–carbon [C(sp
3)–C(sp
3), C(sp
3)–C(sp
2), C(sp
2)–C(sp
2)] and carbon–heteroatom (C–N, C–O, C–P, C–S) bonds. Therefore, in this mini-review, we are emphasizing recently developed various cross-coupling reactions catalysed by transition-metal dual-catalysis (i.e., using palladium and copper catalysts, but omitting the reports on photoredox/metal catalysis).1	Introduction2	Cu/Pd-Catalysed Bond Formation2.1	Pd/Cu-Catalysed C(sp
3)–C(sp
2) Bond Formation2.2	Pd/Cu-Catalysed C(sp
2)–C(sp
2) Bond Formation2.3	Pd/Cu-Catalysed C(sp)–C(sp
2) Bond Formation2.4	Pd/Cu-Catalysed C(sp
3)–C(sp
3) Bond Formation2.5	Pd/Cu-Catalysed C–X (X = B, N, P, S, Si) Bond Formation3	Conclusion
Second exam of right colon improves adenoma detection rate: Systematic review and meta-analysis of randomized controlled trials
Authors: Kamal Faisal , Khan Muhammad Ali , Lee-Smith Wade , Sharma Sachit , Acharya Ashu , Imam Zaid , Farooq Umer , Hanson John , Pulous Vian , Aziz Muhammad , Chandan Saurabh , Kouanda Abdul , Dai Sun-Chuan , Munroe Craig A. , Howden Colin W. 
Published: July 2022

Abstract
Background and study aims A second examination of the right colon, either as a second forward view (SFV) or as retroflexion (RF) in the cecum, can increase adenoma detection rate (ADR) in the right colon. In this meta-analysis, we have evaluated the role of a second examination of the right colon in improving ADR.
Methods We reviewed several databases to identify randomized controlled trials that compared right colon SFV with no SFV, and RCTs that compared SFV with RF in the right colon, and reported data on ADR. Our outcomes of interest were ADR and polyp detection rate (PDR) with SFV vs no SFV, right colon and total withdrawal times, and additional ADR and PDR with SFV vs RF. For categorical variables, we calculated pooled risk ratios (RRs) with 95 % confidence intervals (CIs); for continuous variables, we calculated standardized mean difference (SMD) with 95 % CI. Data were analyzed using random effects model.
Results We included six studies with 3901 patients. Comparing SFV with no SFV, right colon ADR and PDR were significantly higher in the SFV group: ADR (RR [95 % CI] 1.39 [1.22,1.58]) and PDR (RR [95 % CI] 1.47 [1.30, 1.65]). We found no significant difference in right colon withdrawal time (SMD [95 % CI] 1.54 [–0.20,3.28]) or total withdrawal time (SMD (95 % CI) 0.37 [–0.39,1.13]) with and without SFV. We found no significant difference in additional ADR between SFV and RF.
Conclusions SFV of the right colon significantly increases right-sided and overall ADR.
Bleeding Propensity in Waldenström Macroglobulinemia: Potential Causes and Evaluation
Authors: Brysland Simone A. , Maqbool M. Gohar , Talaulikar Dipti , Gardiner Elizabeth E. 
Published: July 2022

AbstractWaldenström macroglobulinemia (WM) is a rare, incurable, low-grade, B cell lymphoma. Symptomatic disease commonly results from marrow or organ infiltration and hyperviscosity secondary to immunoglobulin M paraprotein, manifesting as anemia, bleeding and neurological symptoms among others. The causes of the bleeding phenotype in WM are complex and involve several intersecting mechanisms. Evidence of defects in platelet function is lacking in the literature, but factors impacting platelet function and coagulation pathways such as acquired von Willebrand factor syndrome, hyperviscosity, abnormal hematopoiesis, cryoglobulinemia and amyloidosis may contribute to bleeding. Understanding the pathophysiological mechanisms behind bleeding is important, as common WM therapies, including chemo-immunotherapy and Bruton's tyrosine kinase inhibitors, carry attendant bleeding risks. Furthermore, due to the relatively indolent nature of this lymphoma, most patients diagnosed with WM are often older and have one or more comorbidities, requiring treatment with anticoagulant or antiplatelet drugs. It is thus important to understand the origin of the WM bleeding phenotype, to better stratify patients according to their bleeding risk, and enhance confidence in clinical decisions regarding treatment management. In this review, we detail the evidence for various contributing factors to the bleeding phenotype in WM and focus on current and emerging diagnostic tools that will aid evaluation and management of bleeding in these patients.
Development of a New Tool to Assess the Quality of Life of Patients with Hand–Foot Syndrome Receiving Capecitabine-Based Therapy: A Pilot Study
Authors: Jagdish Prathepa , Kaur Navdeep , Kapoor Akhil , Mandavkar Sarika , Ramaswamy Anant , Ostwal Vikas 
Published: July 2022

Background Hand–foot syndrome (HFS) can result in significant deficits in health-related quality of life (HRQOL) and can lead to poor compliance, dose reduction, or interruption. This study was performed to assess the HRQOL with HFS on physical, psychological, social, and sexual aspects of patients receiving capecitabine-based chemotherapy with gastrointestinal cancer along with validating and assessing the reliability score of the questionnaire.
Patients and Methods HFS-related QOL (HF-QOL) questionnaire was developed and validated in a sample of 30 patients randomly selected for this pilot study. The internal consistency of the tool was tested by calculating the Cronbach's α coefficient, while content and construct validity were assessed by Pearson's correlation. Statistical analyses were performed using SPSS version 25.0.
Results Out of 30, 22 (73%) patients were males, mean age was 44 ± 13 years; 21 (70%) patients had grade 1 HFS, while 6 (20%) and 3 (10%) patients had grades 2 and 3 HFS, respectively. Cronbach's α coefficient was high for physical (0.79) and sexual scales (0.79), while it was moderately low for psychological (0.65) and social (0.53) domains. The average HF-QOL scores were 70.6 ± 13.2 in physical domain and 71.3 ± 23.7 in sexual domain indicating poor quality of life (QOL), while it was 50.9 ± 9.9 in social domain indicating moderately worse QOL. Grades 2 and 3 of HFS were found to have statistical significance on physical (0.0001), psychological (0.05), and social (0.02) domains, whereas sexual domain did not have any statistical significance (0.594).
Conclusion This pilot study showed the feasibility of use and validity of a new patient-reported instrument, the HF-QOL, which measures the effect of HFS on daily activities (physical, psychological, social, and sexual domains) after capecitabine-based chemotherapy.
Stroke in Tuberculous Meningitis and Its correlation with Magnetic Resonance Angiography Manifestations
Authors: Kumar Ashok , Mudassir Sanaullah , Sinha Neetu , Babanrao Wankhade Bhagyashri , Ranjan Abhay 
Published: July 2022

Abstract

Objective The primary objective of the study was to assess the location of cerebral infarction and look for corresponding magnetic resonance angiography (MRA) changes in patients with tuberculous meningitis (TBM). We also evaluated the predictors of ischemic stroke in TBM and the impact of these infarctions on patient's outcome.

Methods This was a single-center prospective study between September 2018 and September 2020. Demographic and laboratory parameters were noted. Cranial magnetic resonance imaging and MRA were performed at the time of admission to the hospital.

Results Among 120 patients with TBM, 46 had stroke. Nineteen (15.8%) patients died, of which 12 (10%) suffered from stroke. The most common site of infarction was the basal ganglia (54.3%). The commonest site of MRA abnormalities was the middle cerebral artery (39.1%). British Medical Research Council (BMRC) stage 3, cerebrospinal fluid (CSF) sugar, CSF adenosine deaminase (ADA) level, basal exudates, hydrocephalus, and hyponatremia were found to be predictors of stroke in TBM, while BMRC stage 3, CSF cell count, CSF ADA level, and anemia were found to be significantly associated with mortality in TBM patients with stroke.

Conclusion The basal ganglia were the most common site of ischemic stroke in TBM, and middle cerebral artery was the most often involved intracranial blood vessel. BMRC stage 3 was significantly associated with both stroke and mortality in TBM patients with stroke.
Usage of Surgical Antibiotic Prophylaxis in Routine Otolaryngologic Surgeries in Turkey
Authors: Torun Mümtaz Taner 
Published: July 2022

Abstract
Introduction: Inappropriate antibiotic use in the world leads to an increase in both health care costs and antibiotic resistance. Surgical antibiotic prophylaxis (SAP) is used by most surgeons, especially in the postoperative period.
Objective The aim of the study is to determine the approach of ear, nose, and throat (ENT) specialists to surgical antibiotic prophylaxis in routine surgeries, and to raise awareness regarding inappropriate antibiotic use.
Methods ENT specialists from all over Turkey participated in the study by filling out a data collecting form. The form consisted of 6 questions and was sent to specialists via email. Routine ENT operations such as adenoidectomy, tonsillectomy, adenotonsillectomy, ventilation tube application, septoplasty, rhinoplasty, septorhinoplasty (noncomplicated), tympanoplasty, and simple mastoidectomy were chosen for the study. Data were analyzed statistically.
Results The form results of 110 ENT specialists were evaluated. The rate of participants who used and did not use SAP was 77.3% and 22.7%, respectively. The SAP usage rates of septoplasty, rhinoplasty, and septorhinoplasty operations were 84.7%, 81.2%, and 75.3%, respectively. For tympanoplasty and ventilation tube application operations, the rates were 82.4% and 24.7%, respectively. Finallly, the SAP usage rates of adenoidectomy, tonsillectomy, and adenotonsillectomy were 57.6%, 75.3%, and 72.9%, respectively.
Conclusion Otolaryngological surgeries are often classified as clean or clean-contaminated surgeries. In most studies in the literature, it is reported that SAP use is unnecessary in routine otolaryngological surgery. Providing inservice training, regularly updating the prophylaxis guidelines and sharing these guidelines with surgeons may prevent inappropriate SAP use.
Reversible Splenial Lesion Syndrome and Multisystem Inflammatory Syndrome Findings in a Child with SARS-COV-2 Infection
Authors: Gemici Utku , Güngör Mesut , Kara Bulent , Anik Yonca 
Published: July 2022

AbstractReversible splenial lesion syndrome (RESLES) is a transient lesion in the splenium of the corpus callosum. Etiology includes infections, malignancies, drugs, metabolic disorders, trauma, etc. We reported radiological features of a child with RESLES and multisystem inflammatory syndrome (MIS-C) with severe acute respiratory syndrome COVID-19 (SARS-CoV-2) infection in a 11-year-old boy. Diagnosis of SARS COV-2 infection was based on the detection of antiSARS-CoV-2 IgG and IgM in his serum.
A 90-Day Episode-of-Care Analysis Including Computed Tomography Scans of Robotic-Arm Assisted versus Manual Total Knee Arthroplasty
Authors: Gregory David A. , Coppolecchia Andrea , Scotti Dennis J. , Chen Zhongming , Mont Michael A. , Jacofsky David 
Published: July 2022

AbstractIn this observational, retrospective study, we performed economic analyses between robotic arm-assisted total knee arthroplasty (RATKA) and manual total knee arthroplasty (MTKA). Specifically, we compared: (1) index costs including computed tomography (CT) scans; (2) 90-day postoperative health care utilization, (3) 90-day episode-of-care (EOC) costs, and (4) lengths of stay between CT scan-based robotically-assisted versus MTKAs. A large national database, Blue Health Intelligence (BHI), was used for RATKAs and MTKAs performed between April 1, 2017 and September 30, 2019. Based on strict inclusion–exclusion criteria, with propensity score matching, 4,135 RATKAs and 4,135 MTKAs were identified and analyzed. Index costs to the payer for RATKA patients were found to be less than those for MTKA patients ($29,984 vs. $31,280, p <0.0001). Overall, 90-day EOC costs for RATKA patients were found to be less than that for MTKA patients in the inpatient and outpatient settings. This also holds true for the use of skilled nursing facilities, pharmacies, or other services. In conclusion, the results from our study show that RATKA were associated with lower costs than MTKAs, even when including the cost of CT scans. These results are of marked importance given the emphasis to contain and reduce health care costs.