bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electronic Structure and Magnetic Properties of a High‐Spin MnIIIComplex: [Mn(mesacac)3] (mesacac=1,3‐Bis(2,4,6‐trimethylphenyl)‐propane‐1,3‐dionato)
Authors: Strassner Nina M. , Stipurin Sergej , Koželj Primož , Grin Yuri , Strassner Thomas 
Published: December 2022

AbstractMetal acetylacetonates of the general formula [M(acac)3] (MIII=Cr, Mn, Fe, Co) are among the best investigated coordination compounds. Many of these first‐row transition metal complexes are known to have unique electronic properties. Independently, photophysical research with different β‐diketonate ligands pointed towards the possibility of a special effect of the 2,4,6‐trimethylphenyl substituted acetylacetonate (mesacac) on the electron distribution between ligand and metal (MLCT). We therefore synthesized and fully characterized the previously unknown octahedral title complex. Its solid‐state structure shows a Jahn‐Teller elongation with two Mn−O bonds of 2.12/2.15 Å and four Mn−O bonds of 1.93 Å. Thermogravimetric data show a thermal stability up to 270 °C. High‐resolution mass spectroscopy helped to identify the decomposition pathways. The electronic state and spin configuration of manganese were characterized with a focus on its magnetic properties by measurement of the magnetic susceptibility and triple‐zeta density functional theory (DFT) calculations. The high‐spin state of manganese was confirmed by the determination of an effective magnetic moment of 4.85 μBfor the manganese center.
The contribution of psychological flexibility to functioning in people living with cancer‐related pain
Authors: Duarte Joana , Björkstrand Frida Köhler , McCracken Lance , Perrin Sean 
Published: December 2022

AbstractBackgroundStudies of individuals with non‐cancer‐related chronic pain find that higher levels of psychological flexibility (PF) are associated with less distress, better functioning, and a better response to treatment. People diagnosed with cancer are at a significantly increased risk of developing chronic cancer‐related pain, the presence of which is associated with poorer health outcomes. Little is known about whether PF is applicable to cancer pain. The current study investigates the relationship between chronic cancer‐related pain, distress and functioning, and three theoretical processes proposed by the PF model: pain acceptance, present‐moment focus, and committed action.MethodsAdults (n = 246) with a cancer diagnosis (current or previous), and living in Sweden, completed an online survey involving standardized measures of cancer‐related pain (intensity and impairment), depression, fatigue, PF and social stigma.ResultsModerate to strong correlations were found between PF and all variables. In regression analyses, PF, and particularly pain acceptance, accounted for a large and significant proportion of the observed variance in depression, pain‐related and overall functioning, after controlling for cancer status, pain intensity and social stigma.ConclusionConsistent with studies of non‐cancer‐related pain, higher levels of PF were strongly associated with lower levels of distress and better functioning in individuals with cancer‐related pain. Further studies are needed to further explore these relationships and to determine whether psychosocial treatments targeting PF may be of benefit to people with chronic cancer‐related pain.SignificanceThis study explores the relationship between cancer‐related pain (intensity and impairment), depression, fatigue, overall functioning, social stigma and PF. The findings suggest that higher levels of PF are associated with lower levels of distress and improved functioning in chronic cancer‐related pain, after controlling for cancer status (current, in remission), pain intensity and social stigma.
Maximal exposure of the parapharyngeal internal carotid artery via transnasal and transoral corridors
Authors: Li Lifeng , Zhou Jing , Xu Hongbo , Jin Yonggang , Chen Xiaohong , Carrau Ricardo L. 
Published: December 2022

AbstractBackgroundThe parapharyngeal internal carotid artery (pICA) could be surgically exposed through the transnasal and transoral corridors. However, their potential degree of exposure has not been established sufficiently. This study aims to elucidate the maximal exposure of the pICA via the transnasal and transoral corridors.MethodsAn endonasal transpterygoid nasopharyngectomy for exposure of the pICA was performed on eight cadaveric specimens (16 sides), while a transoral approach for exposure of the pICA was performed on six additional specimens (12 sides). In addition, the CT angiography of 60 consecutive patients (120 sides) was analyzed to establish the potential maximal exposure of the pICA through each corridor.ResultsThe hard palate becomes a restricting factor for the inferior exposure of the pICA via the transnasal approach, whereas the entire pICA segment could be adequately displayed through the transoral corridor. The maximal exposed length of the pICA for a transnasal and transoral approach was 3.08 ± 0.30 cm and 6.56 ± 0.57 cm, respectively. This difference was statistically significant (p < 0.001).ConclusionAn endonasal exposure of the pICA seems limited to its superior aspect, whereas the transoral corridor could provide adequate exposure of the entire length of pICA.
15‐days duration of venetoclax combined with azacitidine in the treatment of relapsed/refractory high‐risk myelodysplastic syndromes: A retrospective single‐center study
Authors: Mei Chen , Ye Li , Ren Yanling , Zhou Xinping , Ma Liya , Xu Gaixiang , Xu Weilai , Lu Chenxi , Yang Haiyang , Luo Yingwan , Jiang Lingxu , Lang Wei , Zhu HongHu , Jin Jie , Tong Hongyan 
Published: December 2022

AbstractThe treatment of patients with refractory and/or relapsed (R/R) high‐risk myelodysplastic syndrome (HR‐MDS) remains a daunting clinical challenge. Venetoclax is a selective BCL‐2 inhibitor, which combined with hypomethylating agents (HMAs), increased responses and prolonged survival in unfit and previously untreated acute myeloid leukemia. We performed a retrospective study of patients with R/R HR‐MDS receiving combination azacytidine (AZA) plus 15‐days duration of venetoclax (VEN‐15d) in order to determine their efficacy and toxicity in this context. We showed that the overall response rate was 57.2% (20/35) and the median over survival was 14 months in R/R MDS. The most common treatment‐emergent adverse events were peripheral blood cytopenias and infectious complications. Our retrospective study showed that the real‐world experience of treating R/R MDS with AZA plus VEN‐15d highlights an encouraging response rate with myelosuppression being the major toxicity. Of note, VEN‐15d with AZA may salvage patients failing to respond optimally to HMAs and reduce the disease‐burden for subsequent allogeneic stem cell transplantation in our analysis. These data of combination AZA plus VEN‐15d in R/R MDS warrant further prospective evaluation in clinical trials.
Family caregivers' experience with healthcare and social care professionals and their participation in health checkups: A cross sectional study in Japan
Authors: Nakayama Gen , Masumoto Shoichi , Haruta Junji , Maeno Tetsuhiro 
Published: December 2022

AbstractBackgroundFor family caregivers, who are generally regarded as a vulnerable population, having regular checkups is a desirable health behavior. This study examined family caregivers' habit of having regular checkups prior to becoming involved with professionals who care for patients, and whether they had had recent checkups. We then examined the association between family caregivers' experience with professionals and their participation in checkups after adjusting for the past habit.MethodsWe conducted a cross sectional survey in Japan between November and December 2020. We recruited family caregivers who were aged 40–74 years and caring for community‐dwelling adult patients. The outcome variable was whether family caregivers had undergone any health checkups since April 2019. We assessed family caregivers' experience using the Japanese version of the Caregivers' Experience Instrument (J‐IEXPAC CAREGIVERS).ResultsOf the 1091 recruited family caregivers, 629 were included in the analysis. Of these, 358 had previously undergone regular checkups, and 158 had no checkups or selected the option “unknown.” Outcome rates in each group were 74.6% and 43.0%, respectively, and 62.0% for all 629 caregivers. Multivariate modified Poisson regression analysis revealed that among the J‐IEXPAC CAREGIVERS scores, only the domain score for attention for the caregiver was significantly associated with family caregivers' participation in checkups (adjusted prevalence ratio per 1 SD increase = 1.07; 95% CI 1.01–1.14).ConclusionsAmong family caregivers' experience with professionals, the factor that focused on caregivers themselves was significantly associated with their participation in checkups. This finding underscores the significance of caregiver‐focused care.
Using school–university partnerships as a development tool in low‐income countries: The case of Myanmar
Authors: Halász Gábor , Thant Sin Khin Khin 
Published: December 2022

AbstractThis article suggests that creating school–university partnerships is a powerful educational development tool not only in highly developed systems but also in low‐income contexts. Using the example of Myanmar, it presents these partnerships as a multi‐functional tool. This tool supports seven functional areas: teacher learning and professional development, educational research, school improvement, university improvement, curriculum design and reform implementation, generating and spreading educational innovations, and enhancing participation and social dialogue. The article also suggests that international development organizations should consider the creation of school–university cooperation as an effective form of intervention in contexts of underdevelopment.
Addition of galactose‐1‐phosphate measurement enhances newborn screening for classical galactosemia
Authors: Daas Suha , Abu Salah Nasser , Anikster Yair , Barel Ortal , Damseh Nadirah S. , Dumin Elena , Fattal‐Valevski Aviva , Falik‐Zaccai Tzipora C. , Habib Clair , Josefsberg Sagi , Korman Stanley H. , Kneller Katya , Landau Yuval , Lerman‐Sagie Tally , Mandel Hanna , Manor Yehoshua , Moady Abdalla Tameemi , Rock Rachel , Rostami Nira , Saada Ann , Saraf‐Levy Talya , Shaul Lotan Nava , Spiegel Ronen , Staretz‐Chacham Orna , Tal Galit , Ulanovsky Igor , Vaisid Taly , Wilnai Yael , Almashanu Shlomo 
Published: December 2022

AbstractGalactosemia is an inborn disorder of carbohydrate metabolism of which early detection can prevent severe illness. Although the assay for galactose‐1‐phosphate uridyltransferase (GALT) enzyme activity has been available since the 1960s, many issues prevented it from becoming universal. In order to develop the Israeli newborn screening pilot algorithm for galactosemia, flow injection analysis tandem mass spectrometry measurement of galactose‐1‐phosphate in archived dried blood spots from newborns with classical galactosemia, galactosemia variants, epimerase deficiency, and normal controls, was conducted. Out of 431 330 newborns screened during the pilot study (30 months), two with classical galactosemia and four with epimerase deficiency were identified and confirmed. Five false positives and no false negatives were recorded. Following this pilot study, the Israeli final and routine newborn screening algorithm, as recommended by the Advisory Committee to the National Newborn Screening Program, now consists of galactose‐1‐phosphate measurement integrated into the routine tandem mass spectrometry panel as the first‐tier screening test, and GALT enzyme activity as the second‐tier performed to identify only newborns suspected to be at risk for classical galactosemia. The GALT enzyme activity cut‐off used in the final algorithm was lowered in order to avoid false positives.
Bacterial profiles and their antibiotic resistance background in superinfections caused by multidrug‐resistant bacteria among COVID‐19 ICU patients from southwest Iran
Authors: Akrami Sousan , Montazeri Effat Abbasi , Saki Morteza , Neisi Niloofar , Khedri Reza , Dini Sahar Allah , Motlagh Atefeh Akbari , Ahmadi Fatemeh 
Published: December 2022

AbstractThis study investigated the bacterial causes of superinfections and their antibiotic resistance pattern in severe coronavirus disease 2019 (COVID‐19) patients admitted to the intensive care unit (ICU) of Razi Hospital in Ahvaz, southwest Iran. In this cross‐sectional study, endotracheal tube (ETT) secretion samples of 77 intubated COVID‐19 patients, confirmed by reverse transcription‐quantitative polymerase chain reaction, were investigated by standard microbiology test and analytical profile index kit. Antibiotic susceptibility testing was performed by disc diffusion. The presence of Haemophilus influenzae and Mycoplasma pneumoniae was investigated by the polymerase chain reaction (PCR). Using culture and PCR methods, 56 (72.7%) of the 77 COVID‐19 patients (mean age of 55 years, 29 male and 27 female) had superinfections. Using culture, 67 isolates including 29 (43.2%) Gram‐positive and 38 (56.7%) Gram‐negative bacteria (GNB) were identified from 49 COVID‐19 patients. The GNB were more predominant than the Gram‐positive pathogens. Klebsiella pneumoniae (28.4%, n = 19/67) was the most common isolate followed by Staphylococcus aureus (22.4%, n = 15/67). Using PCR, 10.4% (8/77) and 11.7% (9/77) of ETT secretion specimens had H. influenzae and M. pneumoniae amplicons, respectively. Gram‐positive and Gram‐negative isolates showed high resistance rates (>70.0%) to majority of the tested antibiotics including fluoroquinolone, carbapenems, and cephalosporins and 68.7% (46/67) of isolates were multidrug‐resistant (MDR). This study showed a high frequency rate of superinfections by MDR bacteria among COVID‐19 patients in southwest Iran. The prevention of long‐term consequences caused by COVID‐19, demands continuous antibiotic surveillance particularly in management of bacterial superinfections.
Soy protein increases cognitive level in mice by modifying hippocampal nerve growth, oxidative stress, and intestinal microbiota
Authors: Dong Beijia , Qi Yuanjin , Sundas Hina , Yang Ruiqi , Zhou Jie , Li Zhicheng 
Published: December 2022

AbstractBACKGROUNDThree kinds of diet containing chicken protein isolate (CPI), bovine milk protein isolate (BMPI), and soy protein isolate (SPI), respectively, were designed to investigate the influences of proteins on cognitive levels and related mechanisms in mice.RESULTSA Morris water maze (MWM) test showed that the SPI group had a higher cognitive level than the BMPI group. Immunohistochemical staining and chemical analysis of the hippocampus showed that the SPI group had higher synaptophysin expression, doublecortin‐positive cell proportion, superoxide dismutase activity, and lower malondialdehyde content compared with the BMPI group. The same parameters in the CPI group were between those of the BMPI and SPI groups. Microbiome sequencing indicated that the three groups differed significantly at the phylum, genus, and species levels, with higher microbial alpha diversity in the CPI and SPI groups. The association of intestinal microbiota with cognitive improvement was also assessed. The present study suggests that soy protein may increase cognitive function by the gut‐brain axis.CONCLUSIONIn contrast with CPI and BMPI, SPI had a better effect on improving the cognitive level in mice, which was achieved through the regulation of hippocampal neural growth, oxidative stress, and intestinal microbiota. © 2022 Society of Chemical Industry.
Variation in hospital utilization of palliative interventions for patients with advanced gastrointestinal cancer near end of life
Authors: Chen Vivi W. , Portuondo Jorge I. , Cooper Zara , Massarweh Nader N. 
Published: December 2022

AbstractBackgroundPatients with advanced gastrointestinal (GI) cancer often undergo noncurative interventions with palliative intent to relieve high symptom burden near end of life. Hospital‐level variation in intervention utilization remains unclear.MethodsNational cohort study of 142 304 patients with stage III or IV GI cancer within the National Cancer Database (2004–2014) who died within 1‐year of diagnosis. Hospitals were stratified by palliative intervention utilization (surgery, chemotherapy, radiation, pain management). Multivariable, multinomial regression evaluated the association between patient/hospital factors and palliative intervention utilization.ResultsAcross 1322 hospitals, median hospital palliative intervention utilization was 12.0% [interquartile range: 0.0%–26.1%]. Utilization increased over time in all but lowest utilizing hospitals. Relative to lowest utilizing hospitals, factors associated with a lower likelihood of care at highest utilizing hospitals included: race (White [ref]; Black—Relative Risk Ratio [RRR] 0.81, 95% confidence interval [0.77–0.85]) and lower income (RRR 0.81 [0.78–0.84]). Factors associated with a higher likelihood included: lower education level (RRR 1.62 [1.55–1.69]) and hospital type (community program [ref]; comprehensive community—RRR 1.33 [1.26–1.41]; academic—RRR 1.88 [1.77–1.99]; integrated network—RRR 1.79 [1.66–1.93]).ConclusionHospital variation in palliative intervention use is substantial and potentially associated with sociodemographic and hospital characteristics. Future work can examine how differences in hospital care processes translate to quantity/quality of life for cancer patients.
Controllability and consumers' preference for sad and happy esthetic stimuli when feeling sad
Authors: Zhang Yu , Hui Michael K. , Du Jiangang 
Published: December 2022

AbstractDrawing on the coping and emotion regulation literature, we argue that when consumers feel sad after a failure, their relative preference for sad (vs. happy) esthetic stimuli is a function of controllability or the extent to which the responsible party have control over the cause of the failure. Specially, when feeling sad, consumers' preference for sad (vs. happy) esthetic stimuli will increase (decrease) with controllability because sad esthetic stimuli facilitate approach‐oriented coping by maintaining consumers' attention toward the failure that elicits their sadness while happy esthetic stimuli facilitate avoidance‐oriented coping by diverting their attention away from the failure. The findings of four experiments provide evidence supporting the hypothesized effect of controllability on consumers' preference for sad (vs. happy) esthetic stimuli, and the predicted mediating role of attention deployment (toward the failure vs. away from the failure) in explaining the effect.
Effects of dietary methionine restriction on age‐related changes in perivascular and beiging adipose tissues in the mouse
Authors: McGilvrey Marissa , Fortier Bethany , Tero Benjamin , Cooke Diana , Cooper Emily , Walker Jeffrey , Koza Robert , Ables Gene , Liaw Lucy 
Published: December 2022

AbstractObjectivePerivascular adipose tissue (PVAT) regulates vascular health. Dietary methionine restriction (MetR) impacts age‐related adiposity, and this study addresses its effects in PVAT.MethodsMale C57BL/6 mice at 8, 52, and 102 weeks of age were fed a standard (0.86%) or low‐methionine (0.12%) diet for 52 weeks in 8‐week‐old and 52‐week‐old mice and for 15 weeks in 102‐week‐old mice.ResultsMice with dietary MetR were resistant to weight gain and maintained a healthy blood profile. Aging increased lipid accumulation, and MetR reversed this phenotype. Notch signaling in inguinal white adipose tissue (iWAT) was decreased by MetR but increased in gonadal white adipose tissue. However, the Notch phenotype of brown adipose tissue (BAT) was not affected by MetR. Uncoupling protein 1 (UCP1) was increased in PVAT, iWAT, and BAT by MetR when initiated in young mice, but this effect was lost in middle‐aged mice.ConclusionsLipid in mouse PVAT peaked at 1 year of age, consistent with peak body mass. MetR reduced body weight, normalized metabolic parameters, and decreased lipid in PVAT in all age cohorts. Mice fed a MetR diet from early maturity to 1 year of age displayed an increased thermogenic adipocyte phenotype in iWAT, PVAT, and BAT, all tissues with thermogenic capacity.
More than just body mass index: Using the Edmonton obesity staging system for pediatrics to define obesity severity in a multi‐ethnic Australian pediatric clinical cohort
Authors: Southcombe Faye , Vivekanandarajah Sinthu , Krstic Slavica , Lin Fang , Chay Paul , Williams Mandy , Khan Jahidur Rahman , Hu Nan , Eapen Valsa , Dennis Sarah , Denney‐Wilson Elizabeth , Lingam Raghu 
Published: December 2022

AbstractBackgroundDespite advancements in the use of body mass index (BMI) to categorize obesity severity in pediatrics, its utility in guiding individual clinical decision making remains limited. The Edmonton Obesity Staging System for Pediatrics (EOSS‐P) provides a way to categorize the medical and functional impacts of obesity according to the severity of impairment. The aim of this study was to describe the severity of obesity among a sample of multicultural Australian children using both BMI and EOSS‐P tools.MethodsThis cross‐sectional study included children aged 2–17 years receiving obesity treatment through the Growing Health Kids (GHK) multi‐disciplinary weight management service in Australia between January to December 2021. BMI severity was determined using the 95th percentile for BMI on age and gender standardized Centre for Disease Control and Prevention (CDC) growth charts. The EOSS‐P staging system was applied across the four health domains (metabolic, mechanical, mental health and social milieu) using clinical information.ResultsComplete data was obtained for 338 children (age 10.0 ± 3.66 years), of whom 69.5% were affected by severe obesity. An EOSS‐P stage 3 (most severe) was assigned to 49.7% of children, the remaining 48.5% were assigned stage 2 and 1.5% were assigned stage 1 (least severe). BMI predicted health risk as defined by EOSS‐P overall score. BMI class did not predict poor mental health.ConclusionUsed in combination, BMI and EOSS‐P provide improved risk stratification of pediatric obesity. This additional tool can help focus resources and develop comprehensive multidisciplinary treatment plans.