bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptual decision-making in autism as assessed by “spot the difference” visual cognition tasks
Authors: Jassim Nazia , Owen Adrian M. , Smith Paula , Suckling John , Lawson Rebecca P. , Baron-Cohen Simon , Parsons Owen 
Published: September 2022

AbstractDiscriminating between similar figures proves to be a remarkably demanding task due to the limited capacity of our visual cognitive processes. Here we examine how perceptual inference and decision-making are modulated by differences arising from neurodiversity. A large sample of autistic (n = 140) and typical (n = 147) participants completed two forced choice similarity judgement tasks online. Each task consisted of “match” (identical figures) and “mismatch” (subtle differences between figures) conditions. Signal detection theory analyses indicated a response bias by the autism group during conditions of uncertainty. More specifically, autistic participants were more likely to choose the “mismatch” option, thus leading to more hits on the “mismatch” condition, but also more false alarms on the “match” condition. These results suggest differences in response strategies during perceptual decision-making in autism.
Total urinary polyphenols and ideal cardiovascular health metrics in Spanish adolescents enrolled in the SI Program: a cross-sectional study
Authors: Laveriano-Santos Emily P. , Arancibia-Riveros Camila , Parilli-Moser Isabella , Ramírez-Garza Sonia L. , Tresserra-Rimbau Anna , Ruiz-León Ana María , Estruch Ramón , Bodega Patricia , de Miguel Mercedes , de Cos-Gandoy Amaya , Carral Vanesa , Santos-Beneit Gloria , Fernández-Alvira Juan M. , Fernández-Jiménez Rodrigo , Lamuela-Raventós Rosa M. 
Published: September 2022

AbstractTo study the relationship between urinary total polyphenol excretion (TPE) in adolescents and ideal cardiovascular (CVH) metrics. 1151 adolescents aged 12.04 (0.46) years participating in the SI! Program for Secondary Schools were selected based on the availability of urine samples and information required to assess CVH metrics. Data on health behaviours (smoking status, body mass index, physical activity, and healthy diet) and health factors (blood pressure, total cholesterol, and blood glucose) were used to calculate the CVH metrics. TPE in urine was analysed by a Folin-Ciocalteu method after solid-phase extraction. Associations between TPE (categorized into tertiles) and CVH metrics (total and separate scores) were assessed using multilevel mixed-effect regression models. Higher TPE levels were associated with higher (healthier) CVH scores and ideal smoking status (OR 1.54, 95% CI 1.10; 1.87, p value = 0.007), physical activity (OR 1.12, 95% CI 1.02; 1.23, p value = 0.022) and total cholesterol (OR 1.78, 95% CI 1.16; 2.73, p value = 0.009) after multivariate adjustment. An association between TPE and total CVH scores was observed only in boys. Girls with higher TPE had higher rates of ideal total cholesterol and blood pressure. According to our findings, higher urinary TPE is related to better CVH scores, with relevant differences in this association by gender.
Liver regeneration after partial hepatectomy is improved in the absence of aryl hydrocarbon receptor
Authors: Rejano-Gordillo Claudia M. , González-Rico Francisco J. , Marín-Díaz Beatriz , Ordiales-Talavero Ana , Nacarino-Palma Ana , Román Ángel C. , Merino Jaime M. , Fernández-Salguero Pedro M. 
Published: September 2022

AbstractThe liver is among the few organs having the ability to self-regenerate in response to a severe damage compromising its functionality. The Aryl hydrocarbon receptor (Ahr) is a transcription factor relevant for the detoxification of xenobiotics but also largely important for liver development and homeostasis. Hence, liver cell differentiation is developmentally modulated by Ahr through the controlled expression of pluripotency and stemness-inducing genes. Here, 2/3 partial hepatectomy (PH) was used as a clinically relevant approach to induce liver regeneration in Ahr-expressing (Ahr+/+) and Ahr-null (Ahr−/−) mice. Ahr expression and activity were early induced after 2/3 PH to be gradually downmodulated latter during regeneration. Ahr−/− mice triggered liver regeneration much faster than AhR+/+ animals, although both reached full regeneration at the latest times. At initial stages after PHx, earlier regenerating Ahr−/− livers had upregulation of cell proliferation markers and increased activation of signalling pathways related to stemness such as Hippo-YAP and Wnt/β-catenin, concomitantly with the induction of pro-inflammatory cytokines TNFa, IL6 and p65. These phenotypes, together with the improved metabolic adaptation of Ahr−/− mice after PHx and their induced sustained cell proliferation, could likely result from the expansion of undifferentiated stem cells residing in the liver expressing OCT4, SOX2, KLF4 and NANOG. We propose that Ahr needs to be induced early during regeneration to fine-tune liver regrowth to physiological values. Since Ahr deficiency did not result in liver overgrowth, its transient pharmacological inhibition could serve to improve liver regeneration in hepatectomized and transplanted patients and in those exposed to damaging liver toxins and carcinogens.
Effects of substrate bias on the sputtering of high density (111)-nanotwinned Cu films on SiC chips
Authors: Yang Zi-Hong , Wu Po-Ching , Chuang Tung-Han 
Published: September 2022

AbstractThis article presents a study of the influence of the substrate bias on the microstructure, preferred orientation, and mechanical and electrical properties of nanotwinned Cu film. The formation of a nanotwinned structure and (111) surface orientation can be properly controlled by applied substrate bias. High density nanotwinned structures were introduced into Cu films sputtered on SiC substrates with over 90% of (111)-orientation at − 150 V. Densely packed Cu nanotwins were observed within the columnar grains stacked up on each other along the film growth direction, with an average twin spacing of 19.4 nm. The Cu films deposited on SiC substrate via bias sputtering had surface roughness of 8.6 to 15.8 nm. The resistivity of the copper nanotwinned films sputtered with various substrate biases varied. The optimal indentation, 2.3 GPa, was found in the nanotwinned Cu film sputtered with a bias voltage of − 150 V. The effects of Ar ion bombardment on microstructure, surface morphology and properties are further discussed.
Differential influences of LDL cholesterol on functional outcomes after intravenous thrombolysis according to prestroke statin use
Authors: Kang You-Ri , Kim Joon-Tae , Lee Ji Sung , Kim Beom Joon , Kang Kyusik , Lee Soo Joo , Kim Jae Guk , Cha Jae-Kwan , Kim Dae-Hyun , Park Tai Hwan , Lee Kyung Bok , Lee Jun , Hong Keun-Sik , Cho Yong-Jin , Park Hong-Kyun , Lee Byung-Chul , Yu Kyung-Ho , Oh Mi Sun , Kim Dong-Eog , Ryu Wi-Sun , Choi Jay Chol , Kwon Jee-Hyun , Kim Wook-Joo , Shin Dong-Ick , Sohn Sung Il , Hong Jeong-Ho , Park Man-Seok , Choi Kang-Ho , Cho Ki-Hyun , Park Jong-Moo , Lee Sang-Hwa , Lee Juneyoung , Bae Hee-Joon 
Published: September 2022

AbstractThis study aimed to elucidate whether low-density lipoprotein cholesterol (LDL-C) levels differentially affect functional outcomes after intravenous thrombolysis (IVT) depending on prestroke statin use. Patients with acute ischemic stroke treated with IVT were categorized into low, intermediate, and high LDL-C groups based on LDL-C levels at admission (< 100/100–130/ > 130 mg/dl, respectively). Multivariable logistic regression analyses were performed to explore the relationships between LDL-C and clinical outcomes (good outcomes at 3 months, modified Rankin Scale scores 0–2). The interaction between LDL-C levels and prestroke statin use regarding functional outcomes was investigated. Among the 4711 patients (age, 67 ± 12 years; males, 62.1%) who met the eligibility criteria, compared with the high LDL-C group, the low and intermediate LDL-C groups were not associated with good outcomes at 3 months according to the multivariable analysis. A potential interaction between the LDL-C group and prestroke statin use on good outcomes at 3 months was observed (Pinteraction = 0.07). Among patients with prestroke statin use, low (aOR 1.84 [1.04–3.26]) and intermediate (aOR 2.31 [1.20–4.47]) LDL-C groups were independently associated with a greater likelihood of having a 3-month good outcome. Our study showed that LDL-C was not associated with a 3-month good outcome, but prestroke statin use could modify the influence of LDL-C levels on functional outcomes after IVT.
Catatonia in autism and other neurodevelopmental disabilities: a state-of-the-art review
Authors: Moore Shavon , Amatya Debha N. , Chu Michael M. , Besterman Aaron D. 
Published: September 2022

AbstractIndividuals with neurodevelopmental disabilities (NDDs) may be at increased risk for catatonia, which can be an especially challenging condition to diagnose and treat. There may be symptom overlap between catatonia and NDD-associated behaviors, such as stereotypies. The diagnosis of catatonia should perhaps be adjusted to address symptom overlap and to include extreme behaviors observed in patients with NDDs, such as severe self-injury. Risk factors for catatonia in individuals with NDDs may include trauma and certain genetic variants, such as those that disruptSHANK3. Common etiologic features between neurodevelopmental disabilities and catatonia, such as excitatory/inhibitory imbalance and neuroimmune dysfunction, may partially account for comorbidity. New approaches leveraging genetic testing and neuroimmunologic evaluation may allow for more precise diagnoses and effective treatments.
Insights into the molecular mechanism of a new efficient whole-cell biocatalystEnterobacter ludwigiiYYP3 in 5-hydroxymethylfurfural reduction
Authors: Pan Xin , Wang Xue , Wu Sihua , Xu Lei , Zhang Leilei , Zhang Zhan , Li Bingfeng , He Xuejun , Chang Siyuan 
Published: September 2022

A new whole-cell biocatalystE. ludwigiiYYP3 was applied in the conversion of HMF to BHMF and exhibited outstanding catalytic efficiency and cycling stability. Its underlying molecular mechanism, especially the target enzymes responsible for HMF reduction, was revealed.
A novel single sensor based fault/branch location method in distribution systems based on combination of game theory and Dijkstra's algorithm
Authors: Mohammadniaei Mostafa , Namdari Farhad , Shakarami Mahmoud‐Reza , Mousavinick Seyed Ali 
Published: September 2022

AbstractThis paper proposes a branch and fault locating method based on traveling wave theory. This method requires only one sensor in the system to detect the fault location. In this method, the distribution system is assumed to be an undirected graph, with the edges and vertices representing the transmission lines and buses. In addition, the weight of each edge equals the length of the line in the system. Dijkstra's algorithm graph determines all the point candidates for fault at that distance as the fault waves enter the sensor. Subsequently, using the game theory, the fault location and branch of the system are identified out the candidate points. The proposed method is compared with other methods, and it has been proved superior in reducing costs, as well as the lack of dependency on the system's structure, the polarity of the fault wave, and the fault type.
Arithmetic correlation of binary half‐ℓ‐sequences
Authors: Chen Zhixiong , Edemskiy Vladimir , Niu Zhihua , Sang Yuqi 
Published: September 2022

AbstractThe arithmetic correlations of two binary half‐ℓ‐sequences with connection integer pr, which is an odd prime power, are investigated. Possible values (of the arithmetic correlation) are calculated. In particular, if p ≡ 1 (mod 8), the authors prove that they are zero for non‐trivial shifts, that is, the half‐ℓ‐sequences have ideal arithmetic correlations. If p ≡ −1 (mod 8), an upper bound, which is of order of magnitude pr−1/2 ln p, is derived by using earlier results on the imbalance of half‐ℓ‐sequences with connection integer p studied by Gu and Klapper and later improved by Wang and Tan.
Characterization of the Microlensed Hyperspectral Imager prototype
Authors: van Noort M. , Chanumolu A. 
Published: September 2022

Context. The Microlensed Hyperspectral Imager (MiHI) prototype is an integral field spectrograph based on a double-sided microlens array (MLA), installed as an extension to the TRIPPEL spectrograph at the Swedish Solar Telescope (SST).Aims. Due to the mixing of spatial and spectral information in the focal plane, the data are mapped in an interleaved way onto the image sensor. Mapping the information back into its original spatial and spectral dimensions renders the data reduction more complex than usual, and requires the development of a new reduction procedure.Methods. The mapping of the data onto the detector is calculated using a simplified model of the image formation process. Since the moiré fringes that are formed due to the interference of the pixel grid and the MLA grid are a natural consequence of this formation process, the extraction of the data using such a model should eliminate them from the data cubes, thereby eliminating the principal source of instrumentally induced artifacts. In addition, any change in the model caused by small movements of the raw image on the detector can be fitted and included in the model.Results. An effective model of the instrument was fitted using a combination of the numerical results obtained for the propagation of light through an ideal dual microlens system, complemented with an ad hoc fit of the optical performance of the instrument and the individual elements in the MLA. The model includes individual fits for the position, focus, focus gradient, coma, and a few high-order symmetric modes, which are required to account for the spectral crosstalk within each image row. The model is able to accurately reproduce the raw flat-field data from a hyperspectral cube that is virtually free of moiré fringes, and it represents a critical first step in a new hyperspectral data reduction procedure.
Expected Versus Unexpected Delivery for Placenta Accreta Spectrum
(PAS) Disorders with Same Team in Single Tertiary Center
Authors: Golbasi Hakan , Bayraktar Burak , Golbasi Ceren , Omeroglu Ibrahim , Sever Baris , Adiyaman Duygu , Kayhan Omeroglu Seyda , Ekin Atalay , Özeren Mehmet 
Published: September 2022

Abstract
Objectives To evaluate the maternal and neonatal outcomes of expected and
unexpected pathologically proven placenta accreta spectrum (PAS) cases in a
single multidisciplinary center.
Material and Methods This was a retrospective cohort study of 92 PAS cases
from January 2011 until September 2021. Only cases with histopathologically
invasive placentation were included in the study. The cases diagnosed at the
time of delivery were defined as unexpected PAS (uPAS) and those diagnosed
antenatally as expected PAS (ePAS). Maternal and neonatal outcomes of both
groups were compared.
Results Thirty-five (38%) of 92 cases were in the uPAS group.
Placenta previa and high-grade PAS (percreata) were significantly higher in the
ePAS group (p=0.028, p<0.001; respectively). The mean packed red
blood cell transfusion was significantly higher in the uPAS group
(p=0.030) but transfusions of other blood products were similar in the
two groups. There was no significant difference in intraoperative complication
rates between the two groups. Preterm delivery (<37 weeks) was
significantly higher in the ePAS group (p<0.001), but there was no
significant difference between the two groups in terms of adverse neonatal
outcomes.
Conclusions Our single center data show that although ePAS cases include
more highly invasive PAS cases, maternal hemorrhagic morbidity is lower than
uPAS cases. Reducing maternal morbidity in PAS cases can be achieved by
increasing antenatal diagnosis.
Total Synthesis and Anti-inflammatory Activity of Stemoamide-Type Alkaloids Including Totally Substituted Butenolides and Pyrroles
Authors: Soda Yasuki , Sugiyama Yasukazu , Sato Shunsei , Shibuya Kana , Saegusa Junya , Matagawa Tomoe , Kawano Sayaka , Yoritate Makoto , Fukaya Keisuke , Urabe Daisuke , Oishi Takeshi , Mori Kento , Simizu Siro , Chida Noritaka , Sato Takaaki 
Published: September 2022

AbstractTotally substituted butenolide including two tetrasubstituted olefins is a distinct structural motif seen in Stemona alkaloids, but efficient methods for its synthesis are not well developed. As an ongoing program aimed at the collective total synthesis of the stemoamide group, we report a stereodivergent method to give either (E)- or (Z)-totally substituted butenolide from the same intermediate. While AgOTf­-mediated elimination via an E1-type mechanism results in the formation of the kinetic (Z)-tetrasubstituted olefin, subsequent TfOH-mediated isomerization gives the thermodynamic (E)-tetrasubstituted olefin. The pyrrole ring is another important structure found in Stemona alkaloids. The direct oxidation of pyrrolidine rings with MnO2 and careful purification gives the pyrrole groups without isomerization of the stereocenter in the lactone group. These two methods enabled us to synthesize a series of stemoamide-type alkaloids including tricyclic, tetracyclic, and pentacyclic frameworks. The anti-inflammatory activities by inhibition of iNOS expression in macrophage cell line RAW264.7 indicate that the most potent anti-inflammatory compounds without cytotoxicity are protostemonines, which consist of pentacyclic frameworks including the totally substituted butenolide.
Analysis of Benign Retroperitoneal Schwannomas: A Single-center Experience
Authors: Tang Maosheng , Liu Wenqing , Chen Xiaobing , Zou Boyuan , Liu Shibo , Xiao Mengmeng , Luo Chenghua 
Published: September 2022

Abstract
Background Retroperitoneal schwannomas are rare. The purpose of this study was to present our experience with the diagnosis and treatment of 67 such tumors.
Methods We retrospectively analyzed 67 patients with retroperitoneal schwannoma admitted to the Peking University International Hospital from 2015 to 2021.
Results Thirty-seven of the 67 patients had no obvious clinical symptoms. Complete excision was obtained in 62 and subtotal excision in 5 cases. In7 cases, tumor resection was combined with organ resection. The intraoperative blood loss was 300 ml (20–9,000 ml), the maximum size of the tumor was 9 cm (2.5–26 cm), and postoperative complication occurred in six cases (9.0%). Compared with abdominal retroperitoneal tumors, pelvic retroperitoneal tumors had larger tumor volume, more bleeding, higher proportion of block resection, and longer postoperative hospitalization time (p < 0.05). The residual mass progressed slowly in five patients with subtotal resection, and no obvious malignant transformation occurred.
Conclusion Complete resection of a retroperitoneal schwannoma can achieve a good long-term prognosis. Residual tumor after surgery progresses slowly and rarely become malignant. We recommend early resection after the discovery of a pelvic retroperitoneal schwannoma.
UPLC/Q-TOF-MS-based Metabolomics Study of the Antiosteoporosis Effects of Vaccarin in Ovariectomized Mice
Authors: Song Fangming , Xie Tianyu , Liu Xi , Chin Bonnie , Luo Xiaoting , Liao Shijie , Feng Wenyu , He Mingwei , Huang Nenggan , Su Zhiheng , Liu Yun ,   Abu·Moro
Published: September 2022

AbstractOsteoporosis is a systemic and metabolic bone disease that usually occurs in postmenopausal women, which mainly manifests as bone loss and increased bone fragility that both facilitate
fracture. However, few drugs for osteoporosis have shown good efficacy and limited side effects. Vaccarin has demonstrated its antiosteoporosis effects by inhibiting the formation and
osteolytic activities of osteoclasts in our previous investigation. In this study, multivariate statistical analysis and ultrahigh-performance liquid chromatography and quadrupole
time-of-flight tandem mass spectrometry were used to analyze the serum metabolites of ovariectomized mice treated with or without vaccarin. As a result, 9 serum metabolites were identified
as biomarkers. The metabolic levels of 3 crucial biomarkers, namely, lysophosphatidylcholine [22 : 6, (4Z, 7Z, 10Z, 13Z, 16Z, 19Z)], 1-linoleoylglycerophosphocholine and
1-palmitoyl-Sn-glycero-3-phosphocholine, that were correlated with glycerophospholipid metabolism increased and then decreased significantly after vaccarin treatment. Molecular docking
analysis and osteoclasts differentiation experiment further revealed that vaccarin may bind with phospholipase A2 and downregulated its activity to reduce the osteoclastogenesis. Therefore,
the occurrence of osteoporosis is closely related with glycerophospholipid metabolism disorders, and vaccarin exerts antiosteoporosis effects by reducing the levels of glycerophospholipid
metabolites.
Novel Selection Tools in Rhinoplasty Patients
Authors: Lekakis Garyfalia , Constantian Mark , Most Sam P. , Picavet Valerie , Hellings Peter William 
Published: September 2022

AbstractWith no consensus document or guideline to help us compute the psychological make-up of rhinoplasty candidates and in the light of new perspectives of some key opinion leaders in the field of patient selection, the goals of this article are to offer a glimpse of the current literature together with the knowledge gaps, introduce some new tools for the preoperative consultation, help us identify who among our patients is at greatest risk for a poor outcome, and explain how childhood trauma can be linked to body shame and postoperative dissatisfaction.
Biomechanics of Septal L-Strut on Lamb Head Models
Authors: Erol Ozan , Soto-Galindo Germán Armando , Apaydin Fazil 
Published: September 2022

AbstractIt is very crucial to know the biomechanics of the septal cartilage and adjacent structures during septoplasty. The aim of this study was to investigate the strength changes of different L-strut models after mucoperichondrium elevation, application of septal extension grafts and spreader grafts on an experimental lamb model. Ten lamb heads were dissected according to a dissection protocol and septal resistances were measured with the newton meter at six zones. Three different L-strut types were designed, and all the L-strut models were created at different widths of 15mm, 10mm, and 5mm. In addition, effects of two different types of septal extension grafts and spreader grafts were compared. After mucoperichondrium elevation and harvesting the septum cartilage, there was a significant decrease in the septum resistance (p <0.05). As the width of the L-strut decreased, the septum strength decreased significantly (p <0.05). There was no significant difference between three chondrotomy types at different widths (p >0.05). There was no significant difference between the overlapping SEG and end-to-end SEG in terms of septum resistance (p >0.05). This was the first study to measure septal resistance in lamb heads. The mucoperichondrium and L-strut width were important structures for maintaining septal resistance. Chondrotomy style was not crucial, but as the width of the L-strut increased, the septal resistance increased. The septal extension grafts regardless of suturing style and the spreader grafts added strength to the caudal septum.