bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resistant hypertension post-transsphenoidal surgery for pituitary Cushing’s disease, leading to a diagnosis of primary aldosteronism
Authors: Lee Jack , Tomkins Maria , McDonald Darran , Martin-Grace Julie , Carthy Claire , Finnegan John , Mulholland Douglas , Dugal Neal , Hill Arnold D K , O’Reilly Michael W , Sherlock Mark 
Published: February 2025

Summary
We describe a case of a 42-year-old gentleman, 5 years post-transsphenoidal surgery (TSS) for pituitary-dependent Cushing’s disease, initially presenting with malignant hypertension. Despite an initial improvement in his blood pressure post-TSS, he was found to be persistently hypertensive on follow-up despite no clinical or biochemical evidence of recurrence of hypercortisolism. His blood pressure remained elevated despite five antihypertensive agents. His renin concentration was <5 mIU/L (9–103.5) and aldosterone concentration was 877 pmol/L (0–670). A subsequent CT of the adrenals showed a 1.2 cm left adrenal nodule. He was not suitable for adrenal vein sampling (AVS) at this time due to difficult-to-control hypertension. Biochemistry was difficult to interpret in the context of a multitude of interfering medications, which were necessary given his difficult-to-control hypertension and hypokalaemia. Once suitable, his initial AVS was unsuccessful due to failure to cannulate the right adrenal vein. He was given the further options of repeat AVS vs 11C-metomidate PET vs medical management of his blood pressure. He proceeded with a repeat AVS, with successful cannulation of both adrenal veins. This showed evidence of hyperaldosteronism on the left side, with a lateralisation index of 39.5 and a contralateral suppression index of 0.28. He proceeded with a robotic left adrenalectomy, leading to significant improvement in his blood pressure, dropping from a mean reading of 142/85 during daytime and 150/88 mmHg at nighttime on five antihypertensive agents to normotensive levels of 114/77 mmHg on two agents.

Learning points

It is important to consider a broad differential for uncontrolled hypertension.

It must be considered that patients can present with multiple, isolated endocrinopathies.

There are diagnostic challenges with primary aldosteronism, with medication regimens regularly effecting suitability of testing and interpretation of results.

AVS can be a challenging procedure, leading to diagnostic challenges in the lateralisation of primary aldosteronism; however, it or another form of lateralisation is essential to guide management options.
«Уникнення новин»: концептуалізація поняття у світовому та українському контексті
Authors: Hudoshnyk Oksana , Kysil Maksym 
Published: February 2025

За даними Reuters Digital News Report, у 2024 р. 39 % опитаних визнали, що іноді або часто уникають новин. Тому актуальним є огляд зарубіжних концептуальних підходів до поняття «news avoidance» і масштабування результатів наукових рефлексій на національний інформаційний простір. В оглядовій статті сфокусовано увагу на генезі та термінологічних визначеннях, методиках моніторингу та вивчення явища, причинно-наслідкових ефектах, способах коригування сучасних тенденції поступового зменшення уваги до новин; проаналізовано тематичний кластер міжнародної медіареакції на російсько-українську війну у фокусі заявленої теми.
Процес систематизації наукових досліджень і спроби концептуалізації поняття ускладнений акцентуацією на різних сенсоформуючих складниках: контекстних, медіаструткурних, персоналізованих когнитивно-емоційних. Виокремлення ненавмисного та навмисного уникнення новин з відповідною типологією останнього (постійне, випадкове, вибіркове) дозволяє систематизувати характеристики аудиторної поведінки і вилучити теми, що сприяють зростанню вибіркового уникнення новин. У цьому кластері емоційно виснажливі воєнні новини стають факторами індивідуального новинного вибору й не завжди визначають загальну відмову від інформаційного пошуку. Розуміння цих процесів є особливо актуальним для українського інформаційного простору з огляду на стрімке падіння довіри до медіа. За результатами соцдослідження «Медіаспоживання українців: третій рік повномасштабної війни» (ОПОРА/ USAID) динаміка загрозлива: за час війни аудиторія тих, хто не довіряє жодному джерелу інформації зросла від 5,2 % до 15,2 %.
Нелінійність причинно-наслідкових ефектів уникнення новин ускладнює інструментарій аналітичних узагальнень і нестандартність контрстратегій реагування на глобальне явище.
Становлення телевізійного мовлення на Сумщині: концептуальна модель
Authors: Kyrylenko Oksana 
Published: February 2025

Метою дослідження є аналіз концептуальної моделі становлення телевізійного мовлення на Сумщині, ключових етапів його розвитку, особливостей функціонування та ролі у формуванні локального медіапростору. Хронологічні межі охоплюють 1961–1972 рр. Актуальність дослідження зумовлена необхідністю осмислення ретроспективи розвитку локального телебачення, що дозволяє оцінити попередні його моделі та трансполювати результати в сьогодення. Виділено два етапи розвитку. Перший (1961–1968 рр.) — децентралізація телемовлення — характеризується створенням телестудій у Сумах та Конотопі, що було унікальним явищем, оскільки жодна з областей України не мала такого телепредставництва. Телестудії, хоч і регулювалися владними інститутами, мали власні редакційні колективи, самостійно формували контент, орієнтуючись на місцеву аудиторію. Конотопська телестудія випереджала Сумську за обсягом і різноманітністю програм. Другий етап (1968–1972 рр.) — початок централізації місцевого телемовлення — пов’язаний з ліквідацією Конотопської телестудії у 1968 р., що стало наслідком державної політики монополізації інфопростору. Сумська телестудія збільшувала ефірний час, розширювала жанрову палітру, проте залишалася під жорстким ідеологічним контролем. Зростала кількість ретрансляцій Центрального та Українського телебачення. Запровадження двоканального мовлення в 1972 р. остаточно закріпило централізовану модель мовлення. Сумська телестудія, хоч і зберегла місцеву спрямованість, проте стала маргінальним елементом загальнонаціональної медіасистеми. Дослідження відображає загальні тенденції розвитку локальних телемовників, які на сучасному етапі також стикаються з викликами централізації та пошуком ідентичності в умовах глобалізації медіапростору.
Microbial profiles of osteoradionecrosis lesions: a case report with implications for implant-related infections
Authors: Vechiato-Filho Aljomar José , Cláudia Cuzzullin Maria , Leticia Mores Ana , Bianca Brandão Thais , Ricardo Barão Valentim
Adelino , Santo-Silva Alan Roger , Ribeiro e Silva Ana Carolina Prado , Silva Souza João Gabriel 
Published: February 2025

Abstract
Outcome of cataract surgery in patients less than three years of age
Authors: Shetty Sushan Shankar , Pai Vijaya H , Trivedi Divya 
Published: February 2025

To evaluate the outcomes of cataract surgery in children younger than three years, specifically surgical techniques, complications, and postoperative visual acuity. This prospective observational study was conducted at Kasturba Hospital, Manipal, between September 2017 and August 2019. Children under three years old undergoing cataract surgery with at least six months of postoperative follow-up were enrolled. Data collected included surgical procedures, patient demographics, and outcomes, which were analyzed using descriptive statistics. The study included 60 eyes of 37 patients. Bilateral cataracts were present in 62.16% of patients, and congenital cataracts were the most common (56.75%). The most frequent surgical techniques were lens aspiration with posterior primary capsulotomy, anterior vitrectomy, and peripheral iridectomy. Intraocular lens (IOL) implantation was performed in 61.66% of eyes. Postoperative optical rehabilitation consisted of IOLs (61.66%), aphakic glasses (33.34%), and contact lenses (5%). Visual acuity improved in 50% of eyes postoperatively. Complications were observed in 33.33% of eyes, with posterior capsular opacification being the most common (16.67%). Glaucoma was rare (1.67%). The study's limitations included a small sample size and variations in surgical techniques among the four surgeons. Lens aspiration with primary posterior capsulotomy and anterior vitrectomy, with or without IOL implantation, appears to be a safe and effective procedure for pediatric cataracts in children under three, demonstrating notable postoperative visual improvement. Larger, standardized studies are necessary to validate these findings and optimize surgical techniques.
A Life You Know is Dying Like a Statue: Stateless Communities and Intangible Cultural Heritage Safeguarding in Gulf Countries
Authors: Al Shallah Sherine 
Published: February 2025

To understand the extent to which the intangible cultural heritage of stateless communities in Gulf countries is safeguarded under the law, it is necessary to interpret international, regional, and state frameworks around cultural heritage and cultural rights – or human rights to culture. The current study reviews international law and regional frameworks that govern intangible cultural heritage in Gulf countries and examines a case study of the Bidun community in Kuwait. The article focuses on intangible cultural heritage in the context of stateless communities and examines the relationship to tangible cultural heritage as part of the intangible cultural heritage. The study finds that while the legal framework in Gulf countries lays out the groundwork for safeguarding the intangible cultural heritage of stateless communities, some states’ laws and policies are not aligned with obligations under international and regional frameworks.
Real-word study of racial/ethnic disparities and socioeconomic determinants of overall survival in male breast cancer
Authors: Freeman Jincong Q. , Schechter Kent , Nguyen Long C. , Omoleye Olasubomi J. , Hara Jared H. 
Published: February 2025

Abstract

This study assessed racial/ethnic disparities and socioeconomic determinants of overall survival in male breast cancer. Using the 2010–2021 US National Cancer Database, we identified 20,470 patients: 78.2% White, 13.8% Black, 4.0% Hispanic, and 2.5% Asian or Pacific Islander. After adjusting for clinicopathologic characteristics, Black patients had higher mortality than White patients (adjusted hazard ratio [AHR] 1.22, 95% CI: 1.12–1.32); however, when further adjusting for socioeconomic factors, this difference was no longer significant (AHR 1.09, 95% CI: 0.99–1.21). Hispanic patients had better survival. In the TNBC cohort, Asian or Pacific Islander patients had higher mortality than White patients (AHR 2.35, 95% CI: 1.21–4.55), warranting further investigation. In this US male breast cancer cohort, Black patients and White patients had similar mortality risk after further adjusting for socioeconomic indicators. Higher median household income and private insurance were linked to better survival. Strategies addressing socioeconomic inequities may help improve male breast cancer outcomes.
Host serum amyloid A1 facilitates Streptococcus pneumoniae adaptation to acidic stress induced by pneumococcal anaerobic metabolism
Authors: Gong Weichen , Ono Masayuki , Sumitomo Tomoko , Kobayashi Momoko , Hirose Yujiro , Kawabata Shigetada 
Published: February 2025

Abstract

Serum amyloid A1 (SAA1), an acute-phase protein, exhibits a decreased level in bronchoalveolar lavage fluid (BALF) following nasal Streptococcus pneumoniae infections. However, the function of SAA1 in relation to S. pneumoniae remains to be unclear. In this study, we investigate whether S. pneumoniae utilized SAA1 for its survival in host or not. We explored the function of SAA1 in relation to S. pneumoniae by initially comparing serum with high SAA1 levels to serum with low SAA1 levels. We then validated our findings using recombinant SAA1. In this research, we developed an original PBS-based intranasal administration method to induce SAA1 increases in serum. This innovative approach provides a convenient platform for studying the role of SAA1 in various bacterial species. In vitro experiments showed that when serum-THY broth was incubated with S. pneumoniae, a similar reduction in SAA1 was observed, which was proved to be independent of protease activity. Intake of AF488 (green-fluorescent probe)-conjugated recombinant SAA1 by S. pneumoniae was observed using fluoresence microscope. Then, we proved that intake of SAA1 enhanced S. pneumoniae resistance against formate, a key metabolite of its anaerobic metabolism. This study is the first to reveal the relationship between SAA1 and a Gram-positive bacterium. We demonstrate that S. pneumoniae exploits host acute-phase proteins to enhance its survival in formic acidic environments. These findings expand our understanding of bacterial survival strategies, highlighting how pathogens utilize host-derived components to adapt to hostile conditions.
Exploring the Immediate Effects of an Online Self-Regulation Intervention on Pain, Affect, and Arousal in Women with Endometriosis: An Observational Study Protocol
Authors: Moreira Marcelo de França , Oliveira Marco Aurelio Pinho 
Published: February 2025

Abstract

Background
Endometriosis is a chronic condition that affects millions of women worldwide, causing significant pain, emotional distress, and impaired quality of life. Despite advances in biomedical treatments, many patients continue to experience persistent symptoms due to the complex interplay between biopsychosocial factors, shaped by the lived experience of endometriosis and further exacerbated by socioeconomic adversities common in middle- and low-income countries. Self-regulation, the ability to modulate physiological and psychological responses, addresses core mechanisms underlying emotional challenges and pain, potentially benefiting interconnected difficulties. This study aims to evaluate the immediate effects of an online self-regulation intervention that integrates smooth whole-body movements, postural stillness, and deep breathing, explicitly guiding participants to train adaptive psychological attitudes such as present-centered awareness, nonreactivity, and acceptance through body exercises.
Methods
This observational study employs a within-subject, repeated-measures design to assess pre-to-post-session changes in pain intensity, affect, and arousal in women with symptomatic endometriosis. Assessments include self-reported measures of pain, affective states, and psychological attitudes before and after each session. Statistical analyses will use weighted fixed-effects regression models to estimate immediate changes, adjusting for session and clinical predictors. Mixed-effects models will explore individual variability, accounting for repeated measures within participants. Mediation analysis will examine whether nonreactivity and acceptance explain intervention effects on pain and affective outcomes. Additionally, qualitative analysis will be conducted using thematic content analysis of self-reflexive reports to capture participants' spontaneous narratives regarding their engagement with the intervention and its perceived impact beyond predefined quantitative outcomes. Data collection began in August 2024 at the Endometriosis Outpatient Clinic of Pedro Ernesto University Hospital.
Discussion
By investigating the acute effects of a structured online self-regulation intervention, this study aims to provide insights into non-pharmacological strategies for managing endometriosis-related pain and emotional distress. Understanding the short-term impact of the intervention will help refine its delivery and inform future research on long-term effects. Given the limited accessibility of specialized pain management resources, particularly in low- and middle-income settings, this study may contribute to the development of scalable, low-cost therapeutic approaches.
Identification of a broad-spectrum flavivirus inhibitor targeting NS2A, a previously unidentified target
Authors: Goethals Olivia , Borrenberghs Doortje , Chan Kitti Wing Ki , Brandt Sven Van , Jaensch Steffen , Choy Milly , Geluykens Peggy , Bouayadi Asmae El , Lauwers Dax , Bist Pradeep , Stoops Bart , de Ven Jeroen Van , Vermeulen Peter , Megens Sarah , Peeters Danielle , Kaptein Suzanne , Neyts Johan , Vasudevan Subhash , Koul Anil 
Published: February 2025

Abstract

Flaviviruses, such as dengue virus (DENV), Zika virus (ZIKV), West Nile virus (WNV), Japanese encephalitis virus (JEV), and yellow fever virus (YFV), constitute a significant public health concern with billions of people at risk of infection. Climate change and the expanding geographical distribution of mosquito vectors transmitting flaviviruses have increased their potential to cause large-scale disease outbreaks. The frequency and severity of disease outbreaks highlights the urgent need for a broad-spectrum antiviral agent targeting flaviviruses. In this work, we conducted a comprehensive morphological profiling of approximately 200,000 small molecules through a fluorescence-based high-content imaging platform, which led to the identification of a singular small molecule exhibiting broad-spectrum activity against flaviviruses. Subsequent hit deconvolution against DENV serotype 2 (DENV-2) revealed NS2A as a novel therapeutic target and suggested a mechanism whereby the identified small molecule inhibits the interaction between NS2A and the prM protein, revealing a previously uncharacterized antiviral mechanism of action.
The Effect of Roux-en-Y gastric bypass and sleeve gastrectomy on adults with obesity and its Impact on Their Cardiovascular Risk Assessment Score in Abu Dhabi, United Arab Emirates
Authors: Mazrouei Fatima Mohamed Al , Mohamed Alyaa Ali Aal , Nuaimi Aysha Saeed Al , Mazrouei Ruwayya Zayed Al , Marzooqi Dana Mohamed Al , ALZAROONI Amal Abdul Rahim , Maskari Fatima Al , Torab Fawaz , Nimeri Abdelrahman 
Published: February 2025

Abstract

BACKGROUND Obesity is a global health issue with significant public health implications. In addition, obesity plays a role in the development of obesity-related chronic illnesses like type 2 diabetes [T2DM], dyslipidemia, hypertension [HTN], and major adverse cardiovascular events [MACE]. Metabolic and bariatric surgery leads to significant and sustained weight loss and improves T2DM, HTN, dyslipidemia, and a lower rate of MACEs.OBJECTIVE To assess the impact of Roux-en-Y gastric bypass [RYGB] and sleeve gastrectomy [SG] on Framingham risk score and the major modifiable cardiovascular risk factors including Type 2 Diabetes, dyslipidemia, and hypertension.MATERIALS AND METHODS A single-center retrospective cohort study, for all adult patients with obesity who underwent RYGB or SG at the Bariatric & Metabolic Institute (BMI Abu Dhabi) at Sheikh Khalifa Medical City (SKMC), United Arab Emirates (UAE) from January 2010 to December 2013. The cardiovascular risk score was calculated for 2 years before and 2 years after undergoing RYGB or SG for each patient. Electronic medical records were reviewed. All statistical analysis and data analysis were carried out using the R software, version 3.0.3RESULTS During the study period, 363 adults with obesity underwent bariatric surgery at BMI Abu Dhabi (220 patients had Laparoscopic Roux-en Y gastric bypass (RYGB), 102 patients had Laparoscopic sleeve gastrectomy (SG), and 41 patients had other type of bariatric procedures). The overall risk reduction in cardiovascular risk score was 34.02% over 2 years from baseline. There was a significant reduction in the cardiovascular risk score in the first year after RYGB and SG followed by a plateau for the second year. Additionally, systolic blood pressure (SBP) improved by 9.02%, diastolic blood pressure (DBP) improved by 7.52%, and body mass index (BMI) improved by 39.93%. In addition, the total cholesterol, triglycerides, and low-density lipoprotein (LDL) levels declined by 9.07%, 29.98%, and 21.93% respectively. Furthermore, there was a considerable increase in high-density lipoprotein (HDL) levels of 35.65% over the same time, drop in glycated Hemoglobin (HbA1c) by 10.79%, drop in fasting blood glucose (FBS) by 10.30%, and drop in random blood glucose (RBG) by 15.55%.CONCLUSION A significant reduction in cardiovascular risk score after RYGB and SG was observed. In addition, RYGB and SG led to significant weight loss and improvement in other obesity-related medical conditions.
Mapping the evolution of priorities for health systems evidence synthesis in a low-income country: A case study of Uganda from 2013 to 2023
Authors: OBUKU Ekwaro A. , APUNYO Robert , NABUDEERE Harriet , SEWANKAMBO Nelson K. 
Published: February 2025

Abstract

RATIONALE Resources for conducting health systems research are often limited and yet millions of research articles, systematic reviews, technical reports, and policy briefs are published annually with a significant proportion hardly read, let alone used for decision making. We aimed to identify health systems research priorities for evidence synthesis; assess the availability, evolution and alignment of this evidence with dynamic priorities; and contextualized our findings in Uganda’s health policies and systems. APPROACH This was a multiple methods study between 2013 and 2023, consisting of a mini–Delphi technique to identify health systems research priorities, an uncontrolled before–and–after assessment of availability of research evidence to support the identified priorities, and a qualitative documentary analysis of evolving health policies and systems in Uganda. MAIN FINDINGS Our findings highlighted financial arrangements as a resilient priority area for health system evidence synthesis in Uganda. Secondly, we found an abundance of existing evidence syntheses from the PDQ-Evidence database, in all the areas including health systems governance and human capital development. Third, we mapped the evolution of health systems priorities in Uganda together with the evidence in PDQ-Evidence over the past decade with the emergence of human capital development as a priority policy concern that received massive investment by the Ministry of Health, and indeed highest increase in researched evidence. The organizational realignment of Uganda’s Ministry of Health responded to the evolving health systems priorities in line with agenda 2030 of the sustainable development goals (SDG). CONCLUSIONS Our study findings suggest that access to evidence by decision makers remains an important challenge in bridging the “know–do–gap”. This calls for health systems researchers in Uganda to constantly engage decision makers about where and how to find relevant research evidence, and further refine their information needs. A key starting point is empowering the Uganda National Health Research Organization to provide an integrated knowledge translation platform for the health sector.