bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACTIVLIM‐Hemo: A new self‐reported, unidimensional and linear measure of activity limitations in persons with haemophilia
Authors: Lobet Sébastien , Lambert Catherine , Foubert Anthe , Chantrain Valérie‐Anne , Roussel Nathalie , Meeus Mira , Devos Ann , Maes Philip , Hermans Cedric , Penta Massimo 
Published: December 2022

AbstractIntroductionTo assess activity limitations in people with haemophilia (PwH), the self‐reported Haemophilia Activity List (HAL) is widely employed, despite several methodological limitations impacting the interpretation of categorical scores. Modern psychometric approaches avoid these limitations by using a probabilistic model, such as the Rasch model. The ACTIVLIM is a Rasch‐built measurement of activity limitations previously validated in several clinical conditions like neuromuscular disorders.AimsThis study sought to develop the ACTIVLIM‐Hemo, meaning an ACTIVLIM scale version specifically adapted to assess daily activity limitations in adult PwH.MethodsDaily activities were assessed as “impossible,” “difficult” or “easy” by 114 PwH (median age of 44 years) with 63 of them reassessed after 12 days. The Rasch Rating Scale model was used to identify activities delineating a unidimensional and linear scale unbiased by demographic and clinical status. Concurrent validity was determined through correlation with the HAL sub‐scores and sum score.ResultsThe ACTIVLIM‐Hemo included 22 pertinent activities, with difficulties independent of demographic and clinical conditions, allowing a reliable measure of activity limitations (PSI = .92) expressed on a linear and unidimensional scale in PwH (7%–100 % range, ceiling effect of 1/114) with excellent test‐retest reliability (ICC = .978). Spearman rank correlations between ACTIVLIM‐Hemo and HAL sub‐scores ranged between .623 and .869.ConclusionsThe ACTIVLIM‐Hemo is an easy‐to‐administer, valid and reliable alternative to HAL in assessing activity limitations in PwH. Its invariant scale can be used across conditions and time to compare the functional status of PwH over a wide measurement range.
Effect of sofosbuvir and velpatasvir therapy on clinical outcome in hepatitis C virus patients with decompensated cirrhosis
Authors: Tahata Yuki , Sakamori Ryotaro , Maesaka Kazuki , Doi Akira , Yamada Ryoko , Kodama Takahiro , Hikita Hayato , Miyazaki Masanori , Nozaki Yasutoshi , Kaneko Akira , Oshita Masahide , Tanaka Satoshi , Imanaka Kazuho , Hiramatsu Naoki , Morishita Naoki , Ohkawa Kazuyoshi , Yakushijin Takayuki , Sakakibara Mitsuru , Iio Sadaharu , Doi Yoshinori , Tatsumi Tomohide , Takehara Tetsuo 
Published: December 2022

AbstractAimTo determine the impact of direct‐acting antiviral therapy on the long‐term prognosis of decompensated cirrhotic patients.MethodsA total of 37 patients with hepatitis C virus‐induced decompensated cirrhosis treated with sofosbuvir and velpatasvir (SOF/VEL group) were prospectively enrolled. For historical control, 65 hepatitis C virus‐positive decompensated cirrhotic patients who did not receive direct‐acting antiviral therapy were included (control group). The incidence rates of hepatocellular carcinoma (HCC), decompensated events with hospitalization, and overall survival were compared between both groups.ResultsA total of 41 patients experienced decompensated events during 15.0 months in the control group, and six patients during 21.6 months in the SOF/VEL group. The cumulative incidence rates of decompensated events after 2 years were significantly higher in the control group (53.1%) than in the SOF/VEL group (14.5%; p < 0.001). A total of 27 patients died within 22.0 months in the control group, and three patients died within 25.6 months in the SOF/VEL group. The overall survival rates after 2 years were significantly lower in the control group (67.6%) than in the SOF/VEL group (91.3%; p = 0.010). A total of 13 patients in the control group developed HCC during 15.8 months, and 10 patients during 17.3 months in the SOF/VEL group. The HCC incidence rates after 2 years were 20.3% and 29.6% in the control and SOF/VEL groups, respectively, with no significant difference (p = 0.327).ConclusionsSOF/VEL therapy may suppress the development of decompensated events and improve the prognosis in decompensated cirrhotic patients; however, the incidence of HCC remains prevalent in these patients irrespective of SOF/VEL therapy.
Comparing surgeon‐ and nephrologist‐inserted Tenckhoff catheters: experience from a metropolitan centre in Sydney
Authors: Shah Nasir , Goswell Alexander , Cuesta Claire , Lemech Lubomyr , Katz Ivor 
Published: December 2022

AbstractBackgroundPeritoneal dialysis (PD) is an effective home‐based form of dialysis. Although several factors limit its use, the timely and successful insertion of a PD catheter is essential for increased uptake.AimsThis retrospective observational study was performed at a tertiary teaching hospital in Sydney with the aim of comparing outcomes of PD catheter insertion using a percutaneous, modified Seldinger technique utilised by a trained nephrologist to the traditional surgical insertion using a mini‐laparotomy.ResultsOver an 8‐year period, 194 PD catheters were inserted. Aside from lower body mass indexes in the nephrologist‐led interventions (P = 0.02), patient demographics were well matched. Time‐to‐insertion was significantly shorter with the percutaneous technique (P < 0.001). Univariant logistic regression noted no difference in the complication rate between the nephrologist‐inserted and surgically inserted groups (likelihood ratio, 1.59; P = 0.08). There were differences in the type of adverse outcomes with each technique. Surgical procedures were more likely to have exit site leaks (P = 0.009) and peritonitis (P = 0.004), whereas procedure abandonment (P = 0.009) was more common in nephrologist‐led procedures.ConclusionsThe current study highlights that with careful patient selection, trained nephrologists in metropolitan areas can successfully insert PD catheters. Our experience noted fewer delays to catheter insertion, with similar total complication rates.
Reproductive biology, length‐weight relationship and diet of co‐occurring butterfly rays, Gymnura poecilura and Gymnura zonura, in Malaysian waters
Authors: Leung Amanda Jhu‐Xhin , Then Amy Yee‐Hui , Loh Kar‐Hoe 
Published: December 2022

AbstractRecent IUCN assessments had resulted in up listing of the status of butterfly rays due to concerns of overfishing, but inadequate biological understanding of these rays prevents meaningful conservation and management measures. Therefore, this study was undertaken to address knowledge gaps in the reproductive biology and diet of longtail butterfly ray (Gymnura poecilura) and zone tail butterfly ray (Gymnura zonura) in Malaysian waters. From surveys of landing sites and fish markets from years 2017 to 2022, size (disc width, DW), weight and maturity were recorded, and stomachs were collected from 94 G. poecilura (N = 39 females and 55 males) and 20 G. zonura (N = 10 females and 10 males) specimens. The length‐weight relationships were significantly different between sexes for G. poecilura. The size at maturity (DW50) was estimated to be 476.0 mm (females), 385.0 mm (males) for G. poecilura and 442.0 mm (combined) for G. zonura. The number of embryos ranged from 1 to 6, and the embryo size was between 73.90 to 130.44 mm DW. Dietary analysis of stomach contents revealed that fish prey was dominant in both G. poecilura [94.4% Index of Relative Importance (IRI)] and G. zonura (100% IRI). Ontogenetic shift was seen in G. poecilura that fed on more variety of prey items, including shrimps, squids and crabs with an increase in body size. Both species co‐occur all along coastal Malaysia although G. zonura is rarely encountered from fisheries surveys along the Strait of Malacca. Given similar habitat associations and dietary habits, G. poecilura may be able to outcompete G. zonura across their shared habitat range. The validity of G. japonica and G. micrura records in Malaysia remains questionable and requires future investigation.
Management and monitoring of pediatric inflammatory bowel disease in the Asia‐Pacific region: A position paper by the Asian Pan‐Pacific Society for Pediatric Gastroenterology, Hepatology, and Nutrition (APPSPGHAN) PIBD Working Group: Surgical management, disease monitoring, and special considerations
Authors: Lee Way Seah , Arai Katsuhiro , Alex George , Treepongkaruna Suporn , Kim Kyung Mo , Choong Chee Liang , Mercado Karen Calixto , Darma Andy , Srivastava Anshu , Aw Marion M. ,   APPSPGHAN PIBD Working Group
Published: December 2022

AbstractDisease phenotype of pediatric inflammatory bowel disease (PIBD) in children from the Asia‐Pacific region differs from that of children from the West. Many parts of Asia are endemic for tuberculosis, making diagnosis and management of pediatric Crohn's disease a challenge. Current available guidelines, mainly from Europe and North America, may not be completely applicable to clinicians caring for children with PIBD in Asia due to differences in disease characteristics and regional resource constraints. This position paper is an initiative from the Asian Pan‐Pacific Society for Pediatric Gastroenterology, Hepatology and Nutrition (APPSPGHAN) that aims to provide an up‐to‐date, evidence‐based approach to PIBD in the Asia‐Pacific region. A group of pediatric gastroenterologists with a special interest in PIBD performed an extensive literature search covering epidemiology, disease characteristics and natural history, management, and monitoring. Attention was paid to publications from the region with special consideration to a resource‐limited setting. This current position paper deals with surgical management, disease monitoring, immunization, bone health, and nutritional issues of PIBD in Asia. A special section on differentiating pediatric Crohn's disease from tuberculosis in children is included. This position paper provides a useful guide to clinicians in the surgical management, disease monitoring, and various health issues in children with IBD in Asia‐Pacific region.
Influence of Laboring People's Mobility and Positional Changes on Birth Outcomes in Low‐Dose Epidural Analgesia Labor: A Systematic Review with Meta‐Analysis
Authors: de Verastegui‐Martín Maite , de Paz‐Fresneda Ana , Jiménez‐Barbero José Antonio , Jiménez‐Ruiz Ismael , Ballesteros Meseguer Carmen 
Published: December 2022

IntroductionFreedom of movement has been identified as a key issue for pregnant individuals during the birthing process, even if they opt for epidural analgesia, which has relegated people to more static positions during birth for many years. The aims of this systematic review were to evaluate the influence of mobility and positional changes on perinatal and neonatal outcomes in people in labor with epidural analgesia, describe the range of movement interventions used during the first and second stage of labor, and describe the level of motor blockade among people with low‐dose epidural analgesia.MethodsBibliographic databases (Web of Science, Cochrane, CINAHL) were consulted from December 2020 to January 2021. The articles selected were clinical trials and observational or analytical studies, the subject of which was mobilization during labor in people with epidural analgesia. The outcome measures were mode of birth, duration of labor, and extrauterine adaptation after birth. A narrative synthesis was used to describe the types of movements interventions employed during the stages of labor and the level of motor blockade among people with low‐dose epidural analgesia.ResultsTen articles were selected (8 clinical trials, one cross‐sectional study, and one quasiexperimental study), with a total sample of 6086 individuals. A meta‐analysis showed nonsignificant results between groups for mode of birth (relative risk [RR], 1.00; 95% CI, 0.87‐1.14), duration of labor (RR, 1.64; 95% CI, ‐34.57 to 37.86), and extrauterine adaptation after birth (RR, 0.86; 95% CI, 0.39‐1.93). There was heterogeneity among studies in the type of movement interventions used during the first and second stage of labor.DiscussionAlthough no clear benefit was observed for mobilization in epidural labor, no detrimental effects were found either, so perinatal care providers should encourage mobilization if the laboring person so desires, throughout the entire childbirth process.
Beyond Basis Basics: Liquidity Demand and Deviations from the Law of One Price
Authors: HAZELKORN TODD M. , MOSKOWITZ TOBIAS J. , VASUDEVAN KAUSHIK 
Published: December 2022

ABSTRACTDeviations from the law of one price between futures and spot prices—the futures‐cash basis—capture information about liquidity demand for equity market exposure in global markets. We show that the basis comoves with dealer and investor futures positions, is contemporaneously positively correlated with futures and spot market returns, and negatively predicts futures and spot returns. These findings are consistent with the futures‐cash basis reflecting liquidity demand that is common to futures and cash equity markets. We find persistent supply‐demand imbalances for equity index exposure reflected in the basis, giving rise to an annual premium of 5% to 6%.
Frequency of translocation of USP‐6 in the aneurysmal bone cyst of the jaw
Authors: Obermeier Katharina Theresa , Schmöckel Elisa , Otto Sven , Haidari Selgai 
Published: December 2022

AbstractBackgroundThis study aims to detect USP6 translocation in aneurysmal cysts located in the jaw and to give an overview of demographic data.MethodsThe present retrospective cohort study includes 10 patients who underwent surgery due to an aneurysmal cyst of the jaw in our hospital between 2002 and 2021. Unstained formalin‐fixed and paraffin‐embedded tissue sections cut at 4 μm thickness were subjected to USP6 FISH testing.ResultsAll patients underwent surgical treatment. In four of ten patients (40%) USP‐6‐translocations have been found.ConclusionBased on the study, it is hypothesized that the aneurysmal bone cyst of the jaw bone may be subject to a different pathomechanism than that of the long bones. Therefore, it seems conceivable that the primary cause of aneurysmal bone cysts in the jaw might differ.
Open‐ended question method investigation: A study with mashed potatoes
Authors: Sharma Chetan , Swaney‐Stueve Marianne , Chambers Edgar , Jayanty Sastry S. , Talavera Martin J. 
Published: December 2022

AbstractTwelve cultivars of potatoes were used for open‐ended question (OEQ) method investigation. OEQs’ were examined for answer box number effect, questioning type, and compared to check‐all‐that‐apply (CATA) in the difficulty of information generation for sensory profile development. Up to four small list‐style answer boxes were recommended for OEQ information collection irrespective of questioning type. A focused questioning technique on specific modalities was found to generate information that is more actionable over‐generalized questioning. The frequency of abstract words was lowest in texture focused open‐ended questioning, followed by aroma or flavor. Overall, OEQ's generated rich information but were difficult to accomplish (more cognitively challenging to respond than CATA, potential ambiguous interpretation of certain terms and dimensionality reduction through data analysis). Irrespective of method type, some cultivars of potato (CO99076‐6R, Purple Majesty, AC99330‐1PY, and Rio Colorado) were found to have similar textures whereas Purple Majesty and Masquerade were similar in flavor. Purple Majesty, Masquerade, CO99076‐6R, and AC99330‐1PY were liked for their texture. Masquerade cultivar was highly liked for aroma, flavor, and texture over others.Practical applicationsThe findings of this study are helpful to understand the type of information open‐ended questions generate and how effectively they can be used to generate terminology in the context of food‐related studies. Open‐ended questions were tested for questioning effect, information type, diversity of responses, and difficulty.
Behavioural responses to chemical cues of predators differ between fire salamander larvae from two different habitats
Authors: Hahn L. G. , Oswald P. , Caspers B. A. 
Published: December 2022

AbstractPrey organisms need to detect predators and respond with adequate antipredator behaviours. To recognize predators, chemosensory cues play a pivotal role, particularly in aquatic ecosystems, where sight may be restricted. However, it is less known whether the ability to use these cues, enabling appropriate antipredator behaviour, varies between subpopulations occupying different habitats with different predation risks. We examined antipredator behaviour of wild‐caught larval fire salamanders (Salamandra salamandra) from two different habitats, ponds and streams. Ponds and streams are inhabited by habitat‐specific predators, such as alpine newts (Ichthyosaura alpestris), which only occur in ponds. We confronted larvae from both habitats with either tap water (control) or tap water that had contained alpine newts (newt treatment) and investigated potential behavioural differences in activity and shelter emergence. In the activity test, pond larvae, but not stream larvae, were significantly less active when faced with chemical cues (potentially kairomones) from newts than those faced with a control stimulus, but stream larvae generally exhibited significantly lower activity than pond larvae. In the shelter‐emergence test, larvae from both habitats spent significantly less time outside a shelter in the newt treatment than in control water. This suggests that larval fire salamanders, independent of their habitat, recognize chemical cues from potential predators and alter their behaviour accordingly. Larvae of both habitats were able to detect and use chemical cues released from potential predators, but they differed slightly in their response to these chemical cues. This finding reflects varying antipredator strategies in response to the habitat‐specific differences.
Sugar intake above international recommendations and oral disease burden: A population‐based study
Authors: Ladeira Lorena Lucia Costa , Nascimento Gustavo G. , Leite Fabio Renato Manzolli , Alves‐Costa Silas , Thomaz Erika Bárbara Abreu Fonseca , Alves Claudia Maria Coelho , Cury Jaime Aparecido , Ribeiro Cecilia Claudia Costa 
Published: December 2022

AbstractObjectiveTo evaluate the association between added sugar intake above the daily limit for the risk of noncommunicable diseases (NCDs) and the Chronic Oral Disease Burden in adolescents.MethodsThis was a population‐based study using cross‐sectional data nested to RPS Cohorts Consortium, São Luís, Brazil, from the 18–19‐year‐old follow‐up (n = 2515). High consumption of added sugars was estimated according to the limits of the World Health Organization guidelines (WHO) (≥5% of total energy/day) and the American Heart Association statement (AHA) (≥25 g/day). The Chronic Oral Disease Burden was a latent variable (number of decayed teeth, periodontal probing depth ≥4 mm, clinical attachment level ≥3 mm, and bleeding on probing). Models were adjusted for Socioeconomic Status, sex, obesity, and plaque index and analyzed through structural equation modeling.ResultsAdolescents had high sugar consumption according to the WHO (78.6%) and AHA (81.4%) recommendations. High sugar intake, according to WHO (SC = 0.096; p = 0.007) and AHA (SC = 0.056; p = 0.027), was associated with a heavier Chronic Oral Disease Burden. Even half of the recommended dose was sufficient to affect some oral disease indicators.ConclusionSugar intake over international statements to prevent NCDs is associated with higher Chronic Oral Disease Burden among adolescents.
Incorporating equity and justice concerns in regulation
Authors: Cecot Caroline , Hahn Robert W. 
Published: December 2022

AbstractUS regulatory agencies have been encouraged to consider the equity and distributional impacts of regulations for decades. This paper examines the extent to which such analysis is done and provides recommendations for improving it. We analyze 189 regulatory impact analyses (RIAs) that monetize at least some benefits and costs prepared by a variety of agencies from October 2003 to January 2021. We find that only two RIAs calculated the net benefits of a policy for a specific demographic group. Furthermore, only 21% of RIAs calculate some benefits by group (typically for demographic groups) and only 20% calculate some costs by group (typically for industry groups such as small entities). Overall, the differences between presidential administrations are relatively small compared to the differences between agencies in their performance using our measures of distributional analysis. We then evaluate a sample of 23 analyses related to environmental justice (EJ) prepared by the Environmental Protection Agency (EPA) between January 2010 and January 2022. The EJ analyses frequently identify disproportionate exposures to pollutants for a variety of groups and discuss the effects of proposed regulations on these exposures, but they rarely consider the distribution of costs and less than half consider any alternatives. To date, virtually no agency prepares a distributional analysis that could help regulators evaluate whether a proposed regulation, on net, advantages or disadvantages a particular group and whether an alternative could generate a preferred distributional outcome.
Assessing the Effect of School Closures on the Spread of COVID-19 in Zurich
Authors: Bekker-Nielsen Dunbar Maria , Hofmann Felix , Held Leonhard ,   on Behalf of the SUSPend modelling consortium
Published: December 2022

Abstract
The effect of school closure on the spread of COVID-19 has been discussed intensively in the literature and the news. To capture the interdependencies between children and adults, we consider daily age-stratified incidence data and contact patterns between age groups which change over time to reflect social distancing policy indicators. We fit a multivariate time-series endemic–epidemic model to such data from the Canton of Zurich, Switzerland and use the model to predict the age-specific incidence in a counterfactual approach (with and without school closures). The results indicate a 17% median increase of incidence in the youngest age group (0–14 year olds), whereas the relative increase in the other age groups drops to values between 2% and 3%. We argue that our approach is more informative to policy makers than summarising the effect of school closures with time-dependent effective reproduction numbers, which are difficult to estimate due to the sparsity of incidence counts within the relevant age groups.
The impact of ideological positions and personal attributes of candidates in intraparty competition: A study under the Swiss open‐list PR System
Authors: Ortega Carmen , Oñate Pablo , Martín Ángel Cazorla 
Published: December 2022

AbstractIntraparty preference voting systems offer different incentives for candidates to cultivate a personal vote, but little is known about how the candidates' policy positions affect their electoral success in intraparty competition. This article analyses the effect of candidates' ideological positions and personal attributes on their preference vote share in the 2015 and 2019 Swiss Lower House elections. We used candidate survey data combined with official election statistics. Our findings demonstrate that the ideological distance between candidates' positions and their party's median position is of minor importance for their electoral success when compared to their personal attributes. However, ideological distance between candidates and their party's median position reduce their preference vote share.