bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrity of Newton’s cooling law based on thermal convection theory of heat transfer and entropy transfer
Authors: Zhao Bo 
Published: September 2022

AbstractAlthough thermal convection is omnipresent in nature and technology and serves important purposes in various energy transport systems, whether convection can be viewed as an independent heat transfer means has long been argued The constant coefficient in the original version or convective heat transfer coefficient defined in the modern version of Newton’s cooling law quantifies the ratio of the surface heat flux to the temperature difference between a body surface and an adjacent fluid. However, none of the consistent analytical expressions for these two coefficients are present in Newton’s cooling law. The inherently complex relationship between these pending coefficients and convective heat flux vectors makes revealing the convective mechanism extremely difficult. Theoretical determination of these coefficients would bring new insights to thermal convection and direct applications to thermal management. Here we theoretically show consistent analytical expressions for the constant and convective heat transfer coefficients for various flows to make Newton’s cooling law a complete scientific law. For this purpose, a three-dimensional (3D) energy transfer theory of thermal convection is developed, and the convective heat flux vector, entropy flux vector and entropy generation rate inside the system are derived for both single-phase and phase-change flows. By recasting a control volume system into an equivalent control mass system and employing the first and second laws of thermodynamics, the fundamental advective heat transfer mode characterized by temperature differences and entropy changes is demonstrated. The physical implications underlying the 3D convective formulae are elucidated. Comparisons of the analytical results with laminar experiments and turbulent flow measurement benchmark data validate our theoretical findings. Our 3D heat and entropy transfer theory will broaden the research area of thermal convection processes and open up a new arena for the design and thermal management of convective heat transfer in single-phase and phase-change flows.
Brain inspired neuronal silencing mechanism to enable reliable sequence identification
Authors: Hodassman Shiri , Meir Yuval , Kisos Karin , Ben-Noam Itamar , Tugendhaft Yael , Goldental Amir , Vardi Roni , Kanter Ido 
Published: September 2022

AbstractReal-time sequence identification is a core use-case of artificial neural networks (ANNs), ranging from recognizing temporal events to identifying verification codes. Existing methods apply recurrent neural networks, which suffer from training difficulties; however, performing this function without feedback loops remains a challenge. Here, we present an experimental neuronal long-term plasticity mechanism for high-precision feedforward sequence identification networks (ID-nets) without feedback loops, wherein input objects have a given order and timing. This mechanism temporarily silences neurons following their recent spiking activity. Therefore, transitory objects act on different dynamically created feedforward sub-networks. ID-nets are demonstrated to reliably identify 10 handwritten digit sequences, and are generalized to deep convolutional ANNs with continuous activation nodes trained on image sequences. Counterintuitively, their classification performance, even with a limited number of training examples, is high for sequences but low for individual objects. ID-nets are also implemented for writer-dependent recognition, and suggested as a cryptographic tool for encrypted authentication. The presented mechanism opens new horizons for advanced ANN algorithms.
Deciphering the virulent Vibrio harveyi causing spoilage in muscle of aquatic crustacean Litopenaeus vannamei
Authors: Gan Lian , Zheng Jianwei , Xu Wei-Hua , Lin Jianhao , Liu Jingshu , Zhang Yu , Wu Zizhan , Lv Zhaolin , Jia Youming , Guo Qingqi , Chen Shijun , Liu Chuanhe , Defoirdt Tom , Qin Qiwei , Liu Yiying 
Published: September 2022

AbstractThe muscle of aquatic crustaceans is perishable and susceptible to environmental contamination. Vibrio harveyi is a widely occurring pathogen in aquatic animals. Here, bath treatment with a virulent V. harveyi strain (which was added directly in the rearing water to imitate environmental contamination) isolated from the muscle of the whiteleg shrimp, Litopenaeus vannamei, caused the muscle of Li. vannamei to display a whitish-opaque appearance due to microscopic changes including muscle lysis, muscle fiber damage and microbial colonization. When administered orally by incorporating this isolate in feed (which is an imitation of infection via natural route), rather than direct invasion followed by colonization in the muscle, this isolate indirectly stimulated severe muscle necrosis in Li. vannamei via steering the enrichment of two important (human) pathogens, V. cholerae and V. vulnificus, and one environmental bacterium Pseudomonas oleovorans, based on the meta-taxonomic analyses. In addition to the scientifically proven viral diseases, our research proved that bacterial agents are also capable of causing muscle spoilage in crustaceans via changing the microbial composition, and that the crustaceans might be exploited as the wide-spectrum sensitive bio-detector to indicate the extent of microbial contamination.
Numerical study of non-Darcy hybrid nanofluid flow with the effect of heat source and hall current over a slender extending sheet
Authors: Raizah Zehba , Alrabaiah Hussam , Bilal Muhammad , Junsawang Prem , Galal Ahmed M. 
Published: September 2022

AbstractThe current evaluation described the flow features of Darcy Forchhemier hybrid nanoliquid across a slender permeable stretching surface. The consequences of magnetic fields, second order exothermic reaction, Hall current and heat absorption and generation are all accounted to the fluid flow. In the working fluid, silicon dioxide (SiO2) and titanium dioxide (TiO2) nano particulates are dispersed to prepare the hybrid nanoliquid. TiO2 and SiO2 NPs are used for around 100 years in a vast number of diverse products. The modeled has been designed as a nonlinear set of PDEs, Which are degraded to the dimensionless system of ODEs by using the similarity transformation. The reduced set of nonlinear ODEs has been numerically estimated through bvp4c package. The outcomes are tested for validity and consistency purpose with the published report and the ND solve technique. It has been noted that the energy curve lessens with the influence of thermodiffusion, Brownian motion and rising number of nanoparticles, while boosts with the result of magnetic field. Furthermore, the concentration outline of hybrid nanoliquid improves with the upshot of chemical reaction.
Fate identification and management strategies of non-recyclable plastic waste through the integration of material flow analysis and leakage hotspot modeling
Authors: Rinasti Aprilia Nidia , Ibrahim Indradhi Faisal , Gunasekara Kavinda , Koottatep Thammarat , Winijkul Ekbordin 
Published: September 2022

AbstractLow priority on waste management has impacted the complex environmental issue of plastic waste pollution, as evident by results of this study where it was found that 24.3% of waste generation in Jakarta and Bandung is emitted into the waterway due to the high intensity of human activity in the urban area. In this study, we investigated the viable integration between material flow analysis and leakage hotspot modeling to improve management strategies for plastic pollution in water systems and open environments. Using a multi-criteria assessment of plastic leakage from current waste management, a material flow analysis was developed on a city-wide scale defining the fate of plastic waste. Geospatial analysis was assigned to develop a calculation for identification and hydrological analysis while identifying the potential amount of plastic leakage to the river system. The results show that 2603 tons of plastic accumulated along the mainstream of the Ciliwung River on an annual basis, and a high-density population like that in Bandung discarded 1547 tons in a one-year period to the Cikapundung River. The methods and results of this study are applicable towards improving the control mechanisms of river rejuvenation from plastic leakage by addressing proper management in concentrated locations.
Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma
Authors: Nakamizo Akira , Miyamatsu Yuichiro , Hirose Haruka , Amano Toshiyuki , Matsuo Satoshi , Fujiwara Minako , Shimamura Teppei , Yoshimoto Koji 
Published: September 2022

AbstractGlioblastoma is the most common brain tumor with dismal outcomes in adults. Metabolic remodeling is now widely acknowledged as a hallmark of cancer cells, but glioblastoma-specific metabolic pathways remain unclear. Here we show, using a large-scale targeted proteomics platform and integrated molecular pathway-level analysis tool, that the de novo pyrimidine synthesis pathway and serine synthesis pathway (SSP) are the major enriched pathways in vivo for patients with glioblastoma. Among the enzymes associated with nucleotide synthesis, RRM1 and NME1 are significantly upregulated in glioblastoma. In the SSP, SHMT2 and PSPH are upregulated but the upstream enzyme PSAT1 is downregulated in glioblastoma. Kaplan–Meier curves of overall survival for the GSE16011 and The Cancer Genome Atlas datasets revealed that high SSP activity correlated with poor outcome. Enzymes relating to the pyrimidine synthesis pathway and SSP might offer therapeutic targets for new glioblastoma treatments.
Multicolor multifocal 3D microscopy using in-situ optimization of a spatial light modulator
Authors: Amin M. Junaid , Zhao Tian , Yang Haw , Shaevitz Joshua W. 
Published: September 2022

AbstractMultifocal microscopy enables high-speed three-dimensional (3D) volume imaging by using a multifocal grating in the emission path. This grating is typically designed to afford a uniform illumination of multifocal subimages for a single emission wavelength. Using the same grating for multicolor imaging results in non-uniform subimage intensities in emission wavelengths for which the grating is not designed. This has restricted multifocal microscopy applications for samples having multicolored fluorophores. In this paper, we present a multicolor multifocal microscope implementation which uses a Spatial Light Modulator (SLM) as a single multifocal grating to realize near-uniform multifocal subimage intensities across multiple wavelength emission bands. Using real-time control of an in-situ-optimized SLM implemented as a multifocal grating, we demonstrate multicolor multifocal 3D imaging over three emission bands by imaging multicolored particles as well as Escherichia coli (E. coli) interacting with human liver cancer cells, at $$\sim 2.5$$

∼
2.5

multicolor 3D volumes per second acquisition speed. Our multicolor multifocal method is adaptable across SLM hardware, emission wavelength band locations and number of emission bands, making it particularly suited for researchers investigating fast processes occurring across a volume where multiple species are involved.
Effects of different water management and fertilizer methods on soil temperature, radiation and rice growth
Authors: Zheng Ennan , Hu Jianyu , Zhu Yinhao , Xu Tianyu 
Published: September 2022

AbstractIn recent decades, the application of organic fertilizer to agricultural soils has attracted wide attention. However, few studies have carefully explored the effects of humic acid fertilizer on soil temperature, radiation, and the physiology of plant leaves, especially when coupled with different irrigation methods. To provide a better growing environment for crops and explore the best regulation method of humic acid fertilizer and irrigation in the farmland soil environment on the Songnen Plain, China, through field experiments, we selected rice as the test crop and applied humic acid fertilizer to the soil with different irrigation methods. The effects of different humic acid fertilizers and irrigation methods on the soil temperature and radiation changes during different growth stages were examined, and the subtle differences in agronomic and fluorescence characteristics in different growth stages of rice plants were compared. The results showed that the soil temperature was not significantly different among all the treatments. However, radiation interception was obviously different, and the best value was observed in the CT5 treatment. The fluorescence indices and leaf chlorophyll relative content (SPAD) differed with the change in humic acid fertilizer application and irrigation methods. At the jointing and heading stages, the Fv/Fm values of the CT5, FT5 and WT5 treatments were larger than those of the other treatments, and the best value was recorded in the CT5 treatment. The differences in NPQ at these two stages were significant, and the NPQ in the CT5 treatment was significantly higher than that in the other treatments (P < 0.05). In general, the QP under control irrigation was greater than that under flood and wet irrigation (P < 0.05). Moreover, there were no significant differences among the gradients under the different humic acid fertilizer application methods in terms of QP (P > 0.05). Additionally, SPAD values were higher under the CT5 and FT5 treatments.
Formulation of a glycolipid:lipopeptide mixture as biosurfactant-based dispersant and development of a low-cost glycolipid production process
Authors: Subsanguan Tipsuda , Khondee Nichakorn , Rongsayamanont Witchaya , Luepromchai Ekawan 
Published: September 2022

AbstractBiosurfactant-based dispersants were formulated by mixing glycolipids from Weissella cibaria PN3 and lipopeptides from Bacillus subtilis GY19 to enhance the synergistic effect and thereby achieve hydrophilic-lipophilic balance. The proportions of each biosurfactant and dispersant-to-oil ratios (DORs) were varied to obtain the appropriated formulations. The most efficient glycolipid:lipopeptide mixtures (F1 and F2) had oil displacement activities of 81–88% for fuel and crude oils. The baffled flask test of these formulations showed 77–79% dispersion effectiveness at a DOR of 1:25. To reduce the cost of the dispersant, this study optimized the glycolipid production process by using immobilized cells in a stirred tank fermenter. Semicontinuous glycolipid production was carried out conveniently for 3 cycles. Moreover, food wastes, including waste coconut water and waste frying oil, were found to promote glycolipid production. Glycolipids from the optimized process and substrates had similar characteristics but 20–50% lower cost than those produced from basal medium with soybean oil in shaking flasks. The lowest cost dispersant formulation (F2*) contained 10 g/L waste-derived cell-bound glycolipid and 10 g/L lipopeptide and showed high dispersion efficiency with various oils. Therefore, this biosurfactant-based dispersant could be produced on a larger scale for further application.
Health-related behavioral changes and incidence of chronic kidney disease: The Japan Specific Health Checkups (J-SHC) Study
Authors: Kimura Hiroshi , Asahi Koichi , Tanaka Kenichi , Iseki Kunitoshi , Moriyama Toshiki , Yamagata Kunihiro , Tsuruya Kazuhiko , Fujimoto Shouichi , Narita Ichiei , Konta Tsuneo , Kondo Masahide , Kasahara Masato , Shibagaki Yugo , Watanabe Tsuyoshi , Kazama Junichiro J. 
Published: September 2022

AbstractThe transtheoretical model (TTM) is a commonly used model of health-related behavioral change. However, the practical effect of using this model for chronic kidney disease (CKD) self-management remains unclear. This study aimed to investigate the association between stages of change for lifestyle behavior and the incidence of CKD in the general Japanese population. A retrospective cohort study was conducted among 178,780 non-CKD participants aged 40–74 years who underwent annual health check-ups for two consecutive years between 2008 and 2009. Health behavior change was determined using questionnaires based on the TTM, which consists of five stages of change (precontemplation, contemplation, preparation, action, and maintenance). The exposure of interest was the change in stages between two years. Participants were categorized into 3 groups ‘improved’, ‘unchanged’, or ‘deteriorated’. The association between the change in stages and the incidence of CKD was examined using logistic regression analysis. After one year of follow-up, 20.0% of participants developed CKD. Participants in the deteriorated group showed a significantly higher risk of CKD incidence than in the improved group. Promoting the stage of change for healthy lifestyle behaviors evaluated by the TTM was associated with a risk reduction for the incidence of CKD.
Plasma galectin-3 concentration and estimated glomerular filtration rate in patients with type 2 diabetes with and without albuminuria
Authors: Chung Jin Ook , Park Seon-Young , Lee Seung Baek , Kang Na-Ri , Cho Dong Hyeok , Chung Dong Jin , Chung Min Young 
Published: September 2022

AbstractThis study aimed to investigate the association between galectin-3 concentration and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus (T2DM) with and without albuminuria. In this cross-sectional study, we examined 334 patients with T2DM. The eGFR was calculated using a creatinine-based formula (eGFRcrea) and a combined creatinine-cystatin C equation (eGFRcrea-cyst). The participants were categorized into two groups based on the urinary albumin-to-creatinine ratio (UACR): patients without albuminuria (UACR < 30 mg/g) and those with albuminuria (UACR ≥ 30 mg/g). Greater concentrations of plasma galectin-3 were associated with lower eGFRcrea-cyst and eGFRcrea levels in patients with and without albuminuria. Plasma galectin-3 concentrations were negatively correlated with eGFRcrea-cyst in patients with normoalbuminuria and albuminuria (γ = − 0.405, P < 0.001; γ = − 0.525, P < 0.001, respectively). Galectin-3 concentrations were significantly associated with eGFRcrea-cyst after adjusting for sex, age, and other confounding factors, including UACR as a categorical or continuous variable in multiple regression analyses (β = − 0.294, 95% CI − 70.804 to − 41.768, P < 0.001; β = − 0.265, 95% CI − 65.192 to − 36.550, P < 0.001, respectively). Likewise, when eGFRcrea-cyst was treated in place of eGFRcrea, this result was replicated in the correlation and regression analyses. Galectin-3 concentration was negatively associated with eGFR in patients with T2DM, independent of albuminuria status.
Following the niche: the differential impact of the last glacial maximum on four European ungulates
Authors: Leonardi Michela , Boschin Francesco , Boscato Paolo , Manica Andrea 
Published: September 2022

AbstractPredicting the effects of future global changes on species requires a better understanding of the ecological niche dynamics in response to climate; the large climatic fluctuations of the last 50,000 years can be used as a natural experiment to that aim. Here we test whether the realized niche of horse, aurochs, red deer, and wild boar changed between 47,000 and 7500 years ago using paleoecological modelling over an extensive archaeological database. We show that they all changed their niche, with species-specific responses to climate fluctuations. We also suggest that they survived the climatic turnovers thanks to their flexibility and by expanding their niche in response to the extinction of competitors and predators. Irrespective of the mechanism behind such processes, the fact that species with long generation times can change their niche over thousands of years cautions against assuming it to stay constant both when reconstructing the past and predicting the future.
Human thymoma-associated mutation of the GTF2I transcription factor impairs thymic epithelial progenitor differentiation in mice
Authors: Giorgetti Orlando B. , Nusser Anja , Boehm Thomas 
Published: September 2022

AbstractFew human tumours present with a recurrent pathognomonic mutation in a transcription factor. Thymomas are an exception, with the majority of some subtypes exhibiting a distinct somatically acquired missense mutation in the general transcription factor GTF2I. Co-dominant expression of wild-type and mutated forms of Gtf2i in the mouse thymic epithelium is associated with aberrant thymic architecture and reduced thymopoietic activity. Phenotypic and molecular characterization of the mutant epithelium indicates that medullary differentiation is particularly affected as a result of impaired differentiation of bi-potent epithelial progenitors. The resulting gene expression signature is dominated by that of immature cortex-like thymic epithelial cells. TCR repertoire analysis of the cytopenic T cell compartment indicates efficient intrathymic selection; hence, despite marked homeostatic proliferation of T cell clones, autoimmunity is not observed. Thus, our transgenic mouse model recapitulates some aspects of the pathophysiology of a genetically defined type of human thymoma.
Interruption of aberrant chromatin looping is required for regenerating RB1 function and suppressing tumorigenesis
Authors: Wen Xuyang , Ding Tianyi , Li Fang , Fan Jiayan , Fan Xianqun , Jia Renbing , Zhang He 
Published: September 2022

AbstractRB transcriptional corepressor 1 (RB1) is a critical regulatory gene in physiological and pathological processes. Genetic mutation is considered to be the main cause of RB1 inactivation. However, accumulating evidence has shown that not all RB1 dysfunction is triggered by gene mutations, and the additional mechanism underlying RB1 dysfunction remains unclear. Here, we firstly reveal that a CCCTC binding factor (CTCF) mediated intrachromosomal looping served as a regulatory inducer to inactivate RB1. Once the core genomic fragment was deleted by Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 (CRISPR/Cas9), this intrachromosomal looping was disrupted. After the open of chromatin, Enhancer of Zeste Homolog 2 (EZH2) was released and decreased the level of Tri-Methyl-Histone H3 Lys27 (H3K27me3) at the RB1 promoter, which substantially restored the expression of RB protein (pRB) and inhibited tumorigenesis. In addition, targeted correction of abnormal RB1 looping using the small-molecule compound GSK503 efficiently restored RB1 transcription and suppressed tumorigenesis. Our study reveals an alternative transcriptional mechanism underlying RB1 dysfunction independent of gene mutation, and advancing the discovery of potential therapeutic chemicals based on aberrant chromatin looping.