bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular photobiomodulation in the treatment of children with temporomandibular disorders: Study protocol for a randomized, controlled, blind, clinical trial
Authors: Sertaje María Roxana Ferreira , Gonçalves Marcela Leticia Leal , Gomes Andréa Oliver , Bruno Laura Hermida , Fossati Ana Laura , Viarengo Natalia Osorio , Santos Elaine Marcilio , Sobral Ana Paula Taboada , Mesquita-Ferrari Raquel Agnelli , Fernandes Kristianne Porta Santos , Horliana Anna Carolina Ratto Tempestini , Motta Lara Jansiski , Bussadori Sandra Kalil 
Published: October 2022

Background:
This study aims to verify if the use of intravascular laser irradiation of blood (ILIB) influences the reduction of pain and increases the range of motion in opening and closing of the mouth in children and adolescents with temporomandibular disorders (TMD).

Methods:
This will be a blind, randomized, and controlled clinical trial, which will be carried out on children between 6 and 12 years of age who enter the Catholic University of Uruguay, Faculty of Health Sciences, Postgraduate School, for treatment. To be included, children must present temporomandibular disorders, based on the diagnostic criteria will be the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). Forty-five participants will be randomized to three groups: Group 1—ILIB with 2 sessions of 20 minutes for 12 weeks (n = 15); Group 2—Placebo laser application with 2 sessions of 20 minutes for 12 weeks (n = 15); Group 3—Control with no treatment (n = 15). Irradiation will be performed by continuous and direct transcutaneous application to the radial artery, by means of a bracelet that inserts the laser beam. The laser to be used is infrared, power 100 mW ± 20%, wavelength 808 nm ± 10 nm, continuous application. RDC/TMD and pain evaluated through a visual analog scale will be the outcome measures.

Discussion:
Due to the low level of evidence, new studies are needed on the effect of ILIB in children with TMD.
Lipoma with osteocartilaginous metaplasia in infrapatellar fat pad: A case report and review of literature
Authors: Kim Segi , Ha Cheungsoo , Kwon Ah-Young , Choi Wonchul 
Published: October 2022

Rationale:
Lipomas are tumors composed of mature adipocytes, originating from the mesoderm, and are the most common soft tissue tumor. According to the World Health Organization classification of human soft tissue and bone tumors, there are 14 types of benign tumors, including mature adipose tissue. Osteolipoma is known as the rarest subtype of lipoma.

Patient concerns:
A 63-year-old female presented to our hospital for the evaluation and treatment of a palpable mass with pain in the right knee.

Diagnosis:
The diagnosis was confirmed as lipoma with osteocartilaginous metaplasia.

Interventions:
Surgical removal of the tumor was performed.

Outcomes:
The main symptoms improved immediately after the surgery and recovered without any complications or recurrence until 2 years after surgery.

Lessons:
Lipoma with osteochondral degeneration is a rare variant of lipoma and it is important to differentiate it from other malignant tumors. Pathological confirmation should be performed after marginal resection of the mass.
Critical Care and Mechanical Ventilation Practices Surrounding Liver Transplantation in Children: A Multicenter Collaborative*
Authors: Maue Danielle K. , Martinez Mercedes , Alcamo Alicia , Beltramo Fernando , Betters Kristina , Nares Michael , Jeyapalan Asumthia , Zinter Matthew , Kamath Sameer , Ridall Leslie , Monde Alexandra , Resch Joseph , Kaushik Shubhi , Kang Elise , Mangus Richard S. , Pike Francis , Rowan Courtney M. 
Published: October 2022

OBJECTIVES:
We aimed to determine which characteristics and management approaches were associated with postoperative invasive mechanical ventilation (IMV) and with a prolonged course of IMV in children post liver transplant as well as describing the utilization of critical care resources.

DESIGN:
Retrospective, multicenter, cohort study of children who underwent an isolated liver transplantation between January 2017 and December 2018.

SETTING:
Twelve U.S., pediatric, liver transplant centers.

PATIENTS:
Three hundred thirty children post liver transplant admitted to the ICU.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Six patients died in our cohort. The median length of PICU stay was 4.5 days (interquartile range [IQR], 2.9–8.2 d). Most patients were initially monitored with arterial catheters (96%), central venous pressures (95%), and liver ultrasound (93%). Anticoagulation (80%), blood product administration (52.4%), and vasoactive agents (23.0%) were commonly used therapies in the first 7 days. In multivariable logistic regression analysis, age (adjusted odds ratio [aOR] 0.9 [0.86–0.95]), open fascia (aOR 7.0 [95% CI, 2.6–18.9]), large center size (aOR 4.3 [95% CI 2.2–8.3]), and higher Model for End-Stage Liver Disease/Pediatric End-Stage Liver Disease scores (aOR 1.04 [95% CI, 1.01–1.06]) were associated with postoperative IMV. In multivariable logistic regression analysis, postoperative day 0 peak inspiratory pressure (PIP) (aOR 1.2 [95% CI, 1.1–1.3]), large center size (aOR 2.9 [95% CI, 1.6–5.4]), and age (aOR 0.89 [95% CI, 0.85–0.95]) were associated with length of IMV greater than 24 hours. Length of IMV greater than 24 hours was associated with bleeding complications (p = 0.03), infections (p = 0.03), graft loss (p = 0.02), and reoperation (p = 0.03).

CONCLUSIONS:
Younger age, preoperative hospitalization, large center size, and open fascia are associated with use of IMV, and younger age, large center size, and postoperative day 0 PIP are associated with prolonged IMV on multivariable analysis. Longer IMV is associated with negative outcomes, making it an important clinical marker.
Breast Reconstruction Free Flap Failure
Authors: Kalmar Christopher L. , Drolet Brian C. , Kassis Salam , Thayer Wesley P. , Higdon Kent K. , Perdikis Galen 
Published: October 2022

Background
Microvascular free tissue transfer is an increasingly popular modality for autologous tissue breast reconstruction. However, flap failure remains an ominous risk that continues to plague surgeons and patients even in the setting of meticulous surgical technique and monitoring. Venous and arterial thromboses are the leading causes of free flap failure. The purpose of this study was to determine whether thrombocytosis is associated with breast free flap failure.

Methods
A retrospective study was conducted of breast reconstruction with free flaps in North America between 2015 and 2020 using the National Surgical Quality Improvement Program database. Patient comorbidities and preoperative laboratory tests were used to determine risk factors for free flap failure.

Results
During the study interval, 7522 female patients underwent breast reconstruction with free flaps, and flap failure occurred in 2.7% patients (n = 203). In multivariate regression analysis, breast free flap failure was significantly higher in patients smoking cigarettes within the past year (P = 0.030; AOR, 1.7) and dyspnea on moderate exertion or at rest (P = 0.025; AOR, 2.6). Furthermore, each 50 K/mcL elevation in platelet count was independently associated with an increased odds of flap failure (P < 0.001; AOR, 1.2). Patients experienced significantly higher rates of flap failure with platelet counts greater than 250 K/mcL (P = 0.004), which remained significant through progressively increasing thresholds up to 450 K/mcL.

Conclusions
Platelet count greater than 250 K/mcL is associated with progressively increasing risk of free flap failure in breast reconstruction. Future studies of personalized patient anticoagulation protocols based on hemostatic metrics may improve free flap survival after autologous tissue breast reconstruction.
Dual-Innervated Free Gracilis Muscle Transfer for Facial Reanimation in Children
Authors: Deramo Paul J. , Seitz Allison J. , Shakir Sameer , Greives Matthew R. , Low David W. , Jackson Oksana A. , Nguyen Phuong D. 
Published: October 2022

Background
Facial palsy may have deleterious effects for pediatric patients. The most common reconstruction is 2-stage free gracilis muscle transfer (FGMT) after cross-face nerve graft (CFNG). This requires a prolonged period from time of surgery to smile. New techniques using both a CFNG and motor nerve to masseter (MNM) as dual power sources in a single-stage surgery have been described in adults. Here, we examine our experience with this technique in children.

Methods
A retrospective study was performed examining patients who underwent dual-innervated single-stage FGMT at 2 pediatric hospitals from 2016 to 2019. Demographics, etiology, perioperative characteristics, time to mandibular and emotional smile, and Sunnybrook scores were recorded.

Results
Five patients met inclusion criteria with a mean age of 11.8 (range, 8–20). Two patients had congenital facial palsy while 3 had acquired facial palsy. Four patients (80%) received dual end-to-end neural coaptations of the CFNG and MNM to the obturator nerve. One (20%) had end-to-side coaptation of the CFNG to the obturator nerve and end-to-end of the MNM to the obturator nerve. The average time to mandibular smile was 103 ± 15.4 days. The average time to emotional smile was 245 ± 48.1 days. The preoperative Sunnybrook scale was 32 ± 7.5 and improved to 55.3 ± 20.6 at 8 months postoperatively.

Conclusions
Dual-innervated FGMT is effective for facial reanimation in children with unilateral facial palsy. Patients can harness a stronger motor source (MNM) and the component of an emotional stimulus (CFNG). This approach may be the new criterion standard pediatric facial reanimation.
Postoperative Clinical and Radiological Analysis of Deviated Noses
Authors: Altinel Dinçer , Serin Merdan , Toplu Gaye 
Published: October 2022

BackgroundAnatomical deformities can greatly alter nasal function, which can be largely corrected during septoplasty and septorhinoplasty operations. In this study, we aimed to objectively measure the results of septoplasty surgeries of deviated noses with radiological analysis and compare the results with clinical evaluations.Patients and MethodsForty patients who were undergoing septorhinoplasty were included in the study. Patients were evaluated with preoperative and postoperative paranasal computed tomography scan measurements and satisfaction surveys.ResultsPreoperative and postoperative mean ± SD septal deviation angle measurements were 11.9 ± 5.3 degrees and 6.5 ± 3.1 degrees, respectively. Preoperative and postoperative mean ± SD septal deviation distance measurements were 7.3 ± 4 and 3 ± 1.3 mm, respectively. Preoperative and postoperative mean ± SD oblique conchal measurement on the deviated side was 17.3 ± 3.2 and 13.4 ± 2.8, respectively. Preoperative and postoperative mean ± SD patient satisfaction survey scores were 17 ± 1.9 and 4.5 ± 1.9 points, respectively.DiscussionTo obtain a nose with a greatly improved functional gains, especially in heavy deviated noses, is an important goal in septorhinoplasty surgery. It is essential to apply the technique that will benefit the patient. The most important success criterion seems to be the regression of the clinical complaints of the patients, which can be proven objectively with computed tomography scan measurements.
LRBA balances antigen presentation and T-cell responsesviaautophagy by binding to PIK3R4 and FYCO1
Authors: Sindram Elena , Deau Marie-Celine , Ligeon Laura-Anne , Sanchez-Martin Pablo , Nestel Sigrun , Jung Sophie , Ruf Stefanie , Mishra Pankaj , Proietti Michele , Günther Stefan , Thedieck Kathrin , Roussa Eleni , Rambold Angelika , Münz Christian , Kraft Claudine , Grimbacher Bodo , Gámez-Díaz Laura 
Published: October 2022

AbstractReduced autophagy is associated with the aberrant humoral response observed in lipopolysaccharide-responsive beige-like anchor protein (LRBA) deficiency; however, the exact molecular mechanism and its impact on T-cell responses remain unknown. We identified two novel LRBA interactors, phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4) and FYVE And Coiled-Coil Domain Autophagy Adaptor 1 (FYCO1). Both proteins play essential roles in different stages of autophagy. PIK3R4 facilitates the production of phosphatidylinositol-3 phosphate (PI(3)P) required for autophagosome formation and autophagosome-lysosome fusion, whereas FYCO1 allows autophagosome movement. LRBA-KO cells showed an impaired PI(3)P production, a delayed autophagosome-lysosome fusion, an accumulation of enlarged autophagosomes, and an atypical lysosomal positioning. These abnormalities led to decreased cargo material degradation and prolonged antigen presentation to T-cells via autophagy, resulting in increased production of proinflammatory cytokines, as autophagy is a major intracellular degradation system for major histocompatibility class II complex (MHCII) loading. Aberrant autophagosome formation, cargo degradation and antigen presentation were rescued by ectopic expression of WT-LRBA. In summary, we identified a novel function of LRBA that is crucial for T-cell-driven response through the interaction with two proteins of the autophagy machinery. These observations may contribute to the exacerbated T-cell dysregulation observed in LRBA-deficient patients.
Enhancing servitization by international consumer integration: the influence of open innovation and co-creation
Authors: Abu Farha Allam K. , Al-Kwifi Osama Sam , Sakka Georgia , Nguyen Phuong V. , Ahmed Zafar U. 
Published: October 2022

PurposeResearch demonstrates that servitization can achieve competitive advantages for firms; however, many firms are unable to achieve their target values due to various challenges. This study proposes a new model in which open innovation and co-creation are utilized to access consumer knowledge during the servitization process when developing customized services for international markets.Design/methodology/approachAn online survey was used to collect the data from 150 manufacturing firms. The data were analyzed using the partial least squares (PLS) approach.FindingsThe results indicate that open innovation positively affects servitization strategy. Moreover, consumer co-creation moderates the impacts of servitization on firm performance.Practical implicationsThis study confirms the significant role of open innovation and consumer integration in the servitization process, establishing that managers should effectively integrate different stakeholders from the service design stage (through open innovation) to the service delivery stage (through co-creation).Originality/valueThe paper's results prominently advance the present body of servitization literature by showing how the implementation of open innovation improves the servitization process, an issue that has been ignored in previous studies. Moreover, it seeks to resolve the inconsistent results on servitization's effect on performance by indicating the role of consumer co-creation in the servitization–performance link.
Users’ trust in black-box machine learning algorithms
Authors: Nakashima Heitor Hoffman , Mantovani Daielly , Machado Junior Celso 
Published: October 2022

PurposeThis paper aims to investigate whether professional data analysts’ trust of black-box systems is increased by explainability artifacts.Design/methodology/approachThe study was developed in two phases. First a black-box prediction model was estimated using artificial neural networks, and local explainability artifacts were estimated using local interpretable model-agnostic explanations (LIME) algorithms. In the second phase, the model and explainability outcomes were presented to a sample of data analysts from the financial market and their trust of the models was measured. Finally, interviews were conducted in order to understand their perceptions regarding black-box models.FindingsThe data suggest that users’ trust of black-box systems is high and explainability artifacts do not influence this behavior. The interviews reveal that the nature and complexity of the problem a black-box model addresses influences the users’ perceptions, trust being reduced in situations that represent a threat (e.g. autonomous cars). Concerns about the models’ ethics were also mentioned by the interviewees.Research limitations/implicationsThe study considered a small sample of professional analysts from the financial market, which traditionally employs data analysis techniques for credit and risk analysis. Research with personnel in other sectors might reveal different perceptions.Originality/valueOther studies regarding trust in black-box models and explainability artifacts have focused on ordinary users, with little or no knowledge of data analysis. The present research focuses on expert users, which provides a different perspective and shows that, for them, trust is related to the quality of data and the nature of the problem being solved, as well as the practical consequences. Explanation of the algorithm mechanics itself is not significantly relevant.
Decomposition abilities and characteristics of pig manure using three insect larvae
Authors: Choi In‐Hag 
Published: October 2022

AbstractThis study investigated the effects of three insect larvae on decomposition abilities and survival rates in Experiment 1 or on pH, total nitrogen, total carbon, and C/N ratio in Experiment 2. A total of hatched 7,500 Tenebrio molitor (TM) larvae, hatched 501 Protaetia brevitarsis seulensis (PBS) larvae, and hatched 15,000 Ptecticus tenebrifer (PT) larvae were randomly subjected to three treatments with three replicates. The treatments were as follows: (1) TM, 5,000 g pig manure + 250 g TM larvae; (2) PBS, 5,000 g pig manure + 250 g PBS larvae; and (3) PT, 5,000 g pig manure + 250 g PT larvae. In Experiment 1, there were significant differences (p < 0.05) in the decomposition abilities of the pig manure from the three insect larvae‐treated groups for 15–30 days. No significant differences in survival rates were observed for any of the in all treatments over time. Decomposition ability and survival rates in pig manure were higher in the PT larvae group than in the PBS and PT larvae groups. In Experiment 2, three insect larvae‐treated pig manure treatments had an effect on total nitrogen for 20 and 30 days, total carbon for 10 and 30 days, and C/N ratio for 20 and 30 days. Thus, our results suggest that the three insect larvae have the ability to decompose pig manure to increase for increasing survival rates or might represent a valuable alternative as organic fertilizer, which could increase the total nitrogen content and decrease C/N ratio.
Effects of dietary bamboo (Phyllostachys pubescens Mazel) culm powder on blood properties and intestinal environment of rabbits
Authors: Kawasaki Kiyonori , Wada Kazuki , Sato Asagi , Zhao Junliang , Takao Natsu , Sato Masaki , Ban Takuma , Yano Kiminobu 
Published: October 2022

AbstractThis study investigated the effects of bamboo powder as an alternative feed for rabbits. The normal hay diet of rabbits was replaced with bamboo culm powder (10% and 20%) and fed to the rabbits until they were 90 days old. The blood samples were collected when the rabbits were 46, 66, and 90 days old to assess the effects of bamboo powder on blood parameters. The organs and intestinal contents were harvested at the age of 90 days, and the functions and morphologies of different organs were evaluated. The concentration of short‐chain fatty acids (SCFAs) and the composition of microbiota in the cecum were measured. Substituting bamboo powder did not affect the growth, hematology profile, intestinal morphologies, and cecum SCFA concentration in rabbits. In contrast, it significantly altered the cecum microbiota composition, particularly the abundance of Ruminococcus and Bacteroides related to fiber degradation and Tyzzerella spp., associated with large intestine inflammation. These findings suggest that the substitution of hay with bamboo powder in rabbit diets does not negatively affect the overall health of rabbits and could be considered an alternative feed for rabbits; nevertheless, the protein and lipid deficiency in the bamboo powder should be taken into account.
Liver holidays? A meta‐analysis of drinking the same amount of alcohol daily or non‐daily and the risk for cirrhosis
Authors: Llamosas‐Falcón Laura , Tran Alexander , Jiang Huan , Rehm Jürgen 
Published: October 2022

AbstractIntroductionSeveral alcohol drinking guidelines indicate that daily alcohol consumption should be avoided because of its negative impact on the liver and to avoid the development of alcohol use disorders. Evidence that supports this recommendation is scarce. Our aim was to compare daily versus non‐daily drinking and its association with liver cirrhosis.MethodsWe conducted a review using PubMed/Medline and Embase as databases, selecting longitudinal or case control studies. A random effects meta‐analysis was conducted.ResultsFive mainly large‐scale studies were retrieved. Daily drinking was associated with a significant increase in risk of liver cirrhosis compared to non‐daily drinking, with a pooled relative risks of 1.71 (95% confidence interval 1.23–2.23) for men and 1.56 (95% confidence interval 1.39–1.74) for women.Discussion and ConclusionsThe consistent exposure to acetaldehyde and other toxins for daily drinkers may explain our findings. There should be days of abstinence to allow the liver to recover, especially for heavier drinkers.
Daily water‐level forecasting for multiple polish lakes using multiple data‐driven models
Authors: Zhu Senlin , Ji Qingfeng , Ptak Mariusz , Sojka Mariusz , Keramatfar Abdalsamad , Chau Kwok Wing , Band Shahab S. 
Published: October 2022

AbstractWater level in lakes fluctuates frequently due to the impact of natural and anthropogenic forcing. Frequent fluctuations of water level will impact lake ecosystems, and it is thus of great significance to have a good knowledge of water‐level dynamics in lakes. However, forecasting daily water‐level fluctuation in lake systems remains a tough task due to its non‐linearity and complexity. In this study, two deep data‐driven models, including gated recurrent unit (GRU) and long short‐term memory (LSTM), were coupled with attention mechanism for the forecasting of daily water level in lakes for the first time. Daily water‐level times series in five lowland lakes in Poland were used to evaluate the models. Root mean squared error (RMSE) and mean average error (MAE) were used for the evaluation of model performance. The modelling results were compared with the traditional feed‐forward neural networks (FFNN), GRU, LSTM, and zero‐order forecast. The modelling results showed that sequential deep learning models do not outperform feed‐forward models in all cases. In most cases, LSTM with attention mechanism (average RMSE = 0.88 cm, average MAE = 0.69 cm) outperforms GRU with attention mechanism (average RMSE = 1.00 cm, average MAE = 0.81 cm). However, attention mechanism did not help to improve the accuracy of the GRU and LSTM for most cases. Based on the average performance in different lakes, GRU performs the best among the deep learning models (average RMSE = 0.84 cm, average MAE = 0.66 cm). Zero‐order forecast models perform better than deep learning models for predicting tomorrow (average RMSE = 0.71 cm, average MAE = 0.39 cm), while deep learning models perform better as the horizon of prediction increases.