bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dilemma of sigmoid volvulus management
Authors: Abdelrahim A , Zeidan S , Qulaghassi M , Ali O , Boshnaq M 
Published: October 2022

Introduction Patients with sigmoid volvulus (SV) are at a high risk of recurrence with increased morbidity and mortality. This study aims to review whether patients with SV underwent definitive surgical treatment after initial endoscopic reduction according to the guidelines, and to compare mortality rate between surgical and conservative management. Methods Retrospective study conducted at East Kent Hospitals University NHS Foundation Trust, included all patients with SV between 2016 and 2018. The primary outcome was 30-day mortality following the initial management of the acute attack. Secondary outcomes were recurrence rate and overall mortality. The median follow-up period was 3 years. Results A total of 40 patients were identified with a median age of 82 years; 27 (67%) were males. Of these 40 patients, 6 (15%) had emergency surgery, 26 (65%) received endoscopic decompression only, and 8 (20%) had planned definitive resection; 32 patients (80%) had recurrence and the median interval between any two episodes was 86 days. The mortality rate among patients with ASA grade 3 or 4 in the three groups, elective surgery, emergency surgery and decompression only, was 0%, 25% and 70% respectively, whereas it was 0%, 50% and 33% in those with ASA grade 2. The mortality rate among patients with similar ASA who had a planned surgery was significantly lower compared with those who did not undergo surgery (p=0.003). Conclusions In patients with sigmoid volvulus, regardless of ASA grade, performing early definitive surgery following initial endoscopic decompression resulted in a statistically significant lower mortality rate.
Graphene oxide enhanced phase change tolerance of Ge2Sb2Se4Te1 for all-optical multilevel non-volatile photonics memory
Authors: Gan Soon Xin , Ng Kok Bin , Chew Jing Wen , Tey Lian Seng , Chong Wen Sin , Chong Wu Yi , Goh Boon Tong , Lai Choon Kong , Madden Steve , Choi Duk-Yong , Ahmad Harith 
Published: October 2022

The low optical loss of

G
e

2

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b

2

S
e

4

T
e

1

(GSST) makes it a potential functional material for all-optical multilevel photonics memory devices that can operate in the optical telecommunication wavelength band. However, the same characteristic also restricted the tolerance of GSST phase change conditions using 1550 nm as an excitation light source. This work reports on the enhancement of GSST phase change condition tolerance using a graphene oxide (GO) intermediate layer on a polymer waveguide platform. The hybrid waveguide exhibits an insertion loss of around 1 dB and a maximum readout contrast of 25% between amorphous and crystalline states, with a step increase in readout contrast of around 5% per step. This work serves as a proof of concept for the implementation of a GSST–GO hybrid structure as an optical functional material in all-optical photonics memory applications.
Prevalence and factors associated with anaemia among pregnant women attending reproductive and child health clinics in Mbeya region, Tanzania
Authors: Abdallah Fatma , John Sauli E. , Hancy Adam , Paulo Heavenlight A. , Sanga Abraham , Noor Ramadhan , Lankoande Fatoumata , Chimanya Kudakwashe , Masumo Ray M. , Leyna Germana H. 
Published: October 2022

Anaemia is a global public health issue, disproportionately affecting vulnerable populations such as pregnant women. The aim of this study was to assess the prevalence of anaemia and to identify factors associated with the condition among pregnant women attending antenatal clinics in the Mbeya Region of Tanzania. A cross sectional study was conducted with 420 pregnant women (<28 weeks of gestation) attending antenatal visits in the 7 districts of the Mbeya Region. A structured questionnaire was used to collect demographic information and eating habits using a 24hours dietary recall. A blood sample was collected and tested for hemoglobin content using the HemoCue 201+. Multivariate analysis was performed using standard logistic regression to explore the association between anaemia status with socio-demographic, reproductive and nutritional factors.
Overall prevalence of anaemia in pregnant women was 25.5%. Out of 107 pregnant women diagnosed with anaemia and, sixty six had mild anaemia. In a multivariate logistical regression analysis anaemic women was associated with pregnant women coming from lower socio-economic status [adjusted OR = 2.40, 95%CI (1.05, 5.48)]. Moreover, anaemia was less associated with pregnant women who were living in Mbeya district council [adjusted OR = 0.28, 95%CI (0.11, 0.72)], consume at least once a day dark green leafy vegetables [adjusted OR = 0.53, 95% CI (0.30, 0.94)], and vegetable liquid cooking oil [adjusted OR = 0.56, 95% CI (0.34, 0.98)]. The prevalence of anaemia among the pregnant women falls in the category of moderate public health problem according to the WHO classification. Low socio-economic status, consumption of green leafy vegetables and vegetable liquid cooking oil were significantly and independently associated with anaemia during pregnancy. Thus, special attention should be given to pregnant women who are in lower socio-economic status and those not consuming vegetables. Interventions that integrate health and nutrition education in reproductive and child health clinics are needed to combat anaemia.
Changes in the salt content of packaged foods sold in supermarkets between 2015–2020 in the United Kingdom: A repeated cross-sectional study
Authors: Bandy Lauren K. , Hollowell Sven , Jebb Susan A. , Scarborough Peter 
Published: October 2022

Background
Excess consumption of salt is linked to an increased risk of hypertension and cardiovascular disease. The United Kingdom has had a comprehensive salt reduction programme since 2003, setting a series of progressively lower, product-specific reformulation targets for the food industry, combined with advice to consumers to reduce salt. The aim of this study was to assess the changes in the sales-weighted mean salt content of grocery foods sold through retail between 2015 and 2020 by category and company.

Methods and findings
Information for products, including salt content (g/100 g), was collected online from retailer websites for 6 consecutive years (2015 to 2020) and was matched with brand-level retail sales data from Euromonitor for 395 brands. The sales-weighted mean salt content and total volume of salt sold were calculated by category and company. The mean salt content of included foods fell by 0.05 g/100 g, from 1.04 g/100 g in 2015 to 0.90 g/100 g in 2020, equivalent to −4.2% (p = 0.13). The categories with the highest salt content in 2020 were savoury snacks (1.6 g/100 g) and cheese (1.6 g/100 g), and the categories that saw the greatest reductions in mean salt content over time were breakfast cereals (−16.0%, p = 0.65); processed beans, potatoes, and vegetables (−10.6%, p = 0.11); and meat, seafood, and alternatives (−9.2%, p = 0.56). The total volume of salt sold fell from 2.41 g per person per day to 2.25 g per person per day, a reduction of 0.16 g or 6.7% (p = 0.54). The majority (63%) of this decrease was attributable to changes in mean salt content, with the remaining 37% accounted for by reductions in sales. Across the top 5 companies in each of 9 categories, the volume of salt sold decreased in 26 and increased in 19 cases. This study is limited by its exclusion of foods purchased out of the home, including at restaurants, cafes, and takeaways. It also does not include salt added at the table, or that naturally occurring in foods, meaning the findings underrepresent the population’s total salt intake. The assumption was also made that the products matched with the sales data were entirely representative of the brand, which may not be the case if products are sold exclusively in convenience stores or markets, which are not included in this database.

Conclusions
There has been a small decline in the salt content of foods and total volume of salt sold between 2015 and 2020, but observed changes were not statistically significant so could be due to random variations over time. We suggest that mandatory reporting of salt sales by large food companies would increase the transparency of how individual businesses are progressing towards the salt reduction targets.
Exploring the association between precipitation and population cases of ocular toxoplasmosis in Colombia
Authors: Boada-Robayo Laura , Cruz-Reyes Danna Lesley , Cifuentes-González Carlos , Rojas-Carabali William , Vargas-Largo Ángela Paola , de-la-Torre Alejandra 
Published: October 2022

Background
Previous studies suggest a relationship between precipitation and ocular toxoplasmosis (OT) reactivation and congenital toxoplasmosis infection. We aimed to investigate the relationship between precipitation and the frequency of new OT cases in Colombia from 2015 to 2019.

Methodology
This retrospective cohort study analyzed data obtained from a claims-based database created by the Colombian Ministry of Health and national registries of precipitation of the Institute of Hydrology, Meteorology, and Environmental Studies. We estimated the daily number of OT cases, interpolating data from the average number of annual cases from 2015 to 2019. Then, we compared exposures (mean daily precipitation) in the case period in which the events (interpolated OT new cases) occurred by a quasi-Poisson regression, combined with a distributed lag non-linear model to estimate the non-linear and lag–response curve.

Principal findings
In the 5-year analysis, there were 1,741 new OT cases. Most of the cases occurred in 2019, followed by 2015 and 2018. New OT cases among departments were significantly different (P< 0.01). The cumulative exposure-response curve was decreasing for most departments. Nevertheless, in Chocó, Bogotá, Cesar, Cauca, and Guajira, when a certain amount of precipitation accumulates, the relative risk (RR) increases, which was contrary to the pattern observed in the other regions. The response curves to the one-day lag showed that precipitation influences the RR; however, the trends vary by department. Finally, an increasing trend in the number of cases was directly proportional to precipitation in Guajira, Atlántico, Norte de Santander, Santander, Caquetá and Quindío (r = 0.84; P< 0.05).

Conclusions
Precipitation influenced the RR for new OT cases. However, varying trends among geographical regions (departments) lead us to hypothesize that other sociodemographic, behavioral, and environmental variables, such as wind and water contamination, could influence the RR.
Comparison of coproprevalence and seroprevalence to guide decision-making in national soil-transmitted helminthiasis control programs: Ethiopia as a case study
Authors: Roose Sara , Leta Gemechu Tadesse , Vlaminck Johnny , Getachew Birhanu , Mekete Kalkidan , Peelaers Iris , Geldhof Peter , Levecke Bruno 
Published: October 2022

Background
WHO recommends periodical assessment of the prevalence of any soil-transmitted helminth (STH) infections to adapt the frequency of mass drug administration targeting STHs. Today, detection of eggs in stool smears (Kato-Katz thick smear) remains the diagnostic standard. However, stool examination (coprology) has important operational drawbacks and impedes integrated surveys of multiple neglected tropical diseases. Therefore, the aim of the present study was to assess the potential of applying serology instead of coprology in STH control program decision-making.

Methodology
An antibody-ELISA based on extract of Ascaris lung stage larvae (AsLungL3-ELISA) was applied in ongoing monitoring activities of the Ethiopian national control program against schistosomiasis and soil-transmitted helminthiasis. Blood and stool samples were collected from over 6,700 students (median age: 11) from 63 schools in 33 woredas (districts) across the country. Stool samples of two consecutive days were analyzed applying duplicate Kato-Katz thick smear.

Principal findings
On woreda level, qualitative (seroprevalence) and quantitative (mean optical density ratio) serology results were highly correlated, and hence seroprevalence was chosen as parameter. For 85% of the woredas, prevalence based on serology was higher than those based on coprology. The results suggested cross-reactivity of the AsLungL3-ELISA with Trichuris. When extrapolating the WHO coproprevalence thresholds, there was a moderate agreement (weighted κ = 0.43) in program decision-making. Using the same threshold values would predominantly lead to a higher frequency of drug administration.

Significance
This is the first time that serology for soil-transmitted helminthiasis is applied on such large scale, thereby embedded in a control program context. The results underscore that serology holds promise as a tool to monitor STH control programs. Further research should focus on the optimization of the diagnostic assay and the refinement of serology-specific program decision-making thresholds.
The influence of sexual arousal on subjective pain intensity during a cold pressor test in women
Authors: Lakhsassi Lara , Borg Charmaine , Martusewicz Sophie , van der Ploeg Karen , de Jong Peter J. 
Published: October 2022

Background & objectives
Pain can be significantly lessened by sex/orgasm, likely due to the release of endorphins during sex, considered potent analgesics. The evidence suggests that endorphins are also present during sexual arousal (that is, prior to sex/orgasm). It follows then that pain can be modulated during sexual arousal, independent of sex/orgasm, too. Accordingly, sexual arousal induced by erotic slides has been demonstrated to lessen pain in men, but not in women. One explanation could be that for women, the erotic slides were not potent enough to elicit a lasting primed state of sexual arousal by the time pain was induced. Thus, the current study aims to optimize the means of inducing a potent state of sexual arousal and subsequently examine the potentially analgesic influence of sexual arousal on pain in women. As a subsidiary aim, the study also assesses whether the anticipated analgesic effect of sexual arousal would be stronger than that of distraction or generalized (non-sexual) arousal.

Methods
Female participants (N = 151) were randomly distributed across four conditions: sexual arousal, generalized arousal, distraction, neutral. Mild pain was induced using a cold pressor while participants were concurrently exposed to film stimuli (pornographic, exciting, distracting, neutral) to induce the targeted emotional states. A visual analogue scale was utilized to measure the subjective level of pain perceived by the participants.

Results
Sexual arousal did not reduce subjective pain. Generalized arousal and distraction did not result in stronger analgesic effects than the neutral condition.

Conclusion
The present findings do not support the hypothesis that sexual arousal alone modulates subjective pain in women. This might be due to the possibility that genital stimulation and/or orgasm are key in pain reduction, or, that feelings of disgust may inadvertently have been induced by the pornographic stimulus and interfered with sexual arousal in influencing pain.
Effects of contact with a dog on prefrontal brain activity: A controlled trial
Authors: Marti Rahel , Petignat Milena , Marcar Valentine L. , Hattendorf Jan , Wolf Martin , Hund-Georgiadis Margret , Hediger Karin 
Published: October 2022

Background
There is a broad range of known effects of animal contact on human mental and physical health. Neurological correlates of human interaction with animals have been sparsely investigated. We investigated changes in frontal brain activity in the presence of and during contact with a dog.

Methods
Twenty-one healthy individuals each participated in six sessions. In three sessions, participants had contact with a dog, and in three control sessions they interacted with a plush animal. Each session had five two-minute phases with increasing intensity of contact to the dog or plush animal from the first to the fourth phase. We measured oxygenated, deoxygenated, and total hemoglobin and oxygen saturation of the blood in the frontal lobe/frontopolar area with functional near-infrared spectroscopy (SenSmart Model X-100) to assess brain activity.

Findings
In both conditions, the concentration of oxygenated hemoglobin increased significantly from the first to the fourth phase by 2.78 μmol/l (CI = 2.03–3.53, p < .001). Oxygenated hemoglobin concentration was 0.80 μmol/l higher in the dog condition compared to in the control condition (CI = 0.27–1.33, p = .004). Deoxygenated-hemoglobin concentration, total hemoglobin concentration, and oxygen saturation showed similar patterns.

Conclusion
Prefrontal brain activation in healthy subjects increased with the rise in interaction closeness with a dog or a plush animal. Moreover, interaction with a dog stimulated more brain activity compared to the control condition, suggesting that interactions with a dog can activate stronger attentional processes and elicit more emotional arousal than interacting with a nonliving stimulus.
Readiness of Ghanaian health facilities to deploy a health insurance claims management software (CLAIM-it)
Authors: Abekah-Nkrumah Gordon , Antwi Maxwell , Attachey Alex Yao , Janssens Wendy , Rinke de Wit Tobias F. 
Published: October 2022

Introduction
Inadequate, inefficient and slow processing of claims are major contributors to the cost of health insurance schemes, and therefore undermining their sustainability. This study uses the Technology, Organisation and Environment (TOE) framework to examine the preparedness of health facilities of the Christian Health Association of Ghana (CHAG) to implement a digital mobile health insurance claims processing software (CLAIM-it), which aims to increase efficiency.

Methods
The study used a cross-sectional mixed method design to collect data (technology and human capital capacity and baseline operational performance of claims management) from a sample of 20 CHAG health facilities across Ghana. While quantitative data was analysed using simple descriptive statistics statistics (frequencies, mean, minimum and maximum values), qualitative interviews were recorded, transcribed and abstracted into two major themes that were reported to re-enforce the quantitative findings.

Results
The quantitative results revealed challenges including inadequate computers and accessories, adequate numbers and skills for claims processing, poor intranets and internet access, absence of a robust post-implementation support system and inadequate standard operating procedures (SOPs) for seamless automation of claims processing. In addition to the above, the qualitative results emphasised the need to make CLAIM-it more flexible and capable of being integrated into third-party softwares. Notwithstanding the challenges, decision-makers in CHAG health facilities see the CLAIM-it software as having better functionality and superior capabilities compared to existing claims processing systems in Ghana.

Conclusion
Notwithstanding the challenges, the CLAIM-it software is more likely to be adopted by decision-makers, given the positive perception in terms of superior functionality. It is important that key actors in claims management at the National Health Insurance collaborate with relevant stakeholders to adopt the CLAIM-it software for claims processing and management in Ghana.
Risk factors of mortality among children under age five in Awi Zone, northwest Ethiopia
Authors: Alemu Yenew , Dessie Habtamu , Birara Melak 
Published: October 2022

BackgroundGlobally, under-five mortality rates have dropped, but in Ethiopia, the under-five mortality rate is still high. In Amhara region, the death of children under the age of five is still a public health problem. This study assessed the risk factors of mortality among children under age five in Awi Zone.MethodA community-based cross-sectional study was conducted from December 1, 2020, up to April 30, 2021. Data entry and analysis were conducted using SPSS version 26 and Stata version 16, respectively. A zero-inflated Poisson regression model was fitted to identify the risk factors of under-five mortality.ResultOut of the 1,340 mothers in the Awi zone, 11.9% of women lost at least one child. Single births (IRR = 0.598, 95% CI: 0.395, 0.906), fathers whose level of education is secondary or above(IRR = 0.223, 95% CI: 0.064, 0.782), mothers who completed their secondary and above education level(IRR = 0.116, 95% CI: 0.014, 0.971), mothers who have birth interval greater than 24 months (IRR = 0.619,95% CI: 0.417, 0.917), 8 and above family size the households (IRR = 0.543, 95% CI: 0.302, 0.976), 31 and above mother age groups (IRR = 0.296, 95% CI: 0.093, 0.943), medium households of mothers (IRR = 0.540, 95% CI: 0.316, 0.920), working mothers (IRR = 1.691, 95% CI: 1.040, 2.748) and mothers who had not antenatal visits during pregnancy (IRR = 2.060, 95% CI: 1.259, 3.371) were significant factors of under-five mortality.ConclusionMother’s age group, preceding birth interval, family size, wealth index, duration of pregnancy, antenatal visits during pregnancy, types of birth, mother’s education level, husband’s education level, and place of delivery were significant factors of under-five mortality in Awi zone. So, Awi zone public health institute, Awi zone children’s and youth office, and other relevant bodies should work to reduce under-five mortality by focusing on child mortality issues.
The use of agile methodologies and their contribution to innovation of the business model: a study of multiple cases in the context of incubators and startups
Authors: Mota Patrícia Guimarães , Silva André Luiz Barbosa da , Limongi Ricardo França Coelho 
Published: October 2022

Purpose: to understand the phenomenon of agile methodologies and their application in the innovation of existing business models. Methodology: a qualitative study, with a multiple case approach. Main results: the empirical findings confirmed the importance of incubator contributions to the development of innovation in incubated startups. Theoretical or methodological contributions: the research corroborates what the literature says on the subject and contributes useful information to the process of implementing agile methodologies. Relevance and originality: this study is relevant because it deals with challenges that are still little known in the implementation of agile methodologies, thus collaborating to fill the gap in the literature. Social or managerial contributions: the results of this study can help startup managers to deal with the adversities in implementing and adapting to agile methodologies; and to seek a more effective monitoring of the incubator throughout this process.