bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking enterprise social media use, trust and knowledge sharing: paradoxical roles of communication transparency and personal blogging
Authors: Masood Ayesha , Zhang Qingyu , Ali Moazzam , Cappiello Giuseppe , Dhir Amandeep 
Published: August 2022

PurposeThe purpose of this study is to investigate the impact of enterprise social media (ESM) use on two trust dimensions – affect-based trust (ABT) and cognition-based trust (CBT) – as mediators in the relationship between ESM use and knowledge sharing. In the first stage of the proposed model, the authors also consider transparent communication (TC) and personal blogging with colleagues (PBC) during work and non-work hours as moderators that reshape trust levels and subsequently promote knowledge sharing within the organisation.Design/methodology/approachThe authors collected the data in three waves from employees in China, the world’s largest market for social media. Five companies, including three information technology companies and two software companies, were targeted for data collection. Initially, a total of 403 ESM users were recruited, but the final sample in the final round was reduced to N = 292. The authors used Mplus (v8.5) to calculate direct path coefficients and indirect moderated-mediation effects.FindingsThe use of ESM promotes ABT and CBT, thereby improving knowledge sharing. ABT and CBT both fully mediate the effect of ESM use on knowledge sharing. However, the research reveals paradoxical findings regarding moderation. For example, on the one hand, TC negatively moderates the association between ESM use and ABT, thereby reducing knowledge sharing in the workplace. On the other hand, TC strengthens the relationship between the use of ESM and CBT, thereby increasing knowledge sharing. These contradictory findings indicate that TC functions as a double-edged sword; thus, the effective use of ESM in the workplace requires managers’ intervention. Finally, the analysis reveals that the moderating role of PBC strengthens the association between ESM use and both ABT and CBT, thereby increasing knowledge sharing.Originality/valueWhile stakeholders have expressed concern regarding the adverse impacts of workplace ESM adoption on employee performance, the authors provide a broad, novel perspective on the potential of ESM use to enhance knowledge sharing via trust (i.e. ABT and CBT). To the best of the authors’ knowledge, this is the first study to offer a comparative view of trust dimensions, such as ABT and CBT, and to discuss how, why and when TC and PBC interactions moderate the relationship of ESM to ABT and CBT and thereby lead to knowledge sharing. These interesting findings guide further research into the role of ESM in the workplace, especially research based on rational choice theory and communication visibility theory, by illuminating the ways in which employees can use ESM to reshape social communication in the workplace and thereby enhance knowledge sharing.
Subsurface characterization using passive seismic in the urban area of Dublin City, Ireland
Authors: Maggio Giuseppe , Subašić Senad , Bean Christopher J. 
Published: August 2022

AbstractWe investigate the shallow geological features and previously unknown depths of the main geological interfaces in the highly urbanized Dublin City area by using a set of complementary ambient noise seismic methods. A sparse seismic array, composed of 19 broadband sensors, was installed in a 5 × 5 km area across the city centre. The dataset was acquired over a 5‐month‐long deployment and used to perform horizontal/vertical spectral ratios and frequency–wave number analysis cross‐correlation interferometry. From the horizontal/vertical high‐frequency resonance peaks, we estimate the depth to bedrock. Then we use a subset of six seismic stations to obtain the frequency–wavenumber Rayleigh wave fundamental mode in the 0.8–3 Hz frequency band. Next, the ambient noise dataset is cross‐correlated in order to extract the empirical Green's functions before measuring surface‐wave phase velocities by undertaking a dispersion analysis in the 0.5–9 Hz frequency band. Then, a Monte Carlo global optimization algorithm is used to invert the phase velocity dispersion measurements. We generate a reference one‐dimensional depth S velocity profile along with a set of localized one‐dimensional S velocity profiles. Finally, a smooth three‐dimensional shear wave velocity model is derived for the top 1000 m in the sedimentary Dublin Basin. From the one‐dimensional velocity profiles and three‐dimensional shear velocity model, with some sensitivity down to approximately 1.2 km, we observe velocity changes with depth that highlight the presence of three consistent interfaces. We discuss interpretative scenarios that correlate the velocity features to potential stratigraphic boundaries occurring within the sedimentary Dublin Basin, suggesting that basement rocks could be located at a depth significantly greater than the top kilometre. The results of this study may indicate that future geothermal studies should be directed at structures deeper than 1 km, towards the bottom of the sedimentary basin beneath the city.
Ginsenoside Rh1 regulates gastric cancer cell biological behaviours and transplanted tumour growth in nude mice via the TGF‐β/Smad pathway
Authors: Yang Zhiwen , Wu Xinlin , Shen Junjie , Gudamu A. , Ma Yongxiang , Zhang Zishu , Hou Mingxing 
Published: August 2022

AbstractGastric cancer (GC) is one of the most prevalent malignancies of the digestive tract. Ginsenoside Rh1 was reported to exert effects on GC. The current study set out to explore the mechanism underlying Ginsenoside Rh1 effects on GC. With oxaliplatin (OXA) serving as the positive control, human GC cells AGS were treated with 0, 10, 25, 50, 74, or 100 μM of ginsenoside Rh1 for 48 h. Proliferation, migration, invasion, and apoptosis were subsequently assessed by means of MTT, scratch test, Transwell, and TUNEL, respectively. AGS cells were further jointly treated with Rh1 and the TGF‐β/Smad pathway activator Kartogenin, followed by detection of TGF‐β/Smad pathway effects on AGS biological behaviours. Moreover, TGF‐β/Smad pathway activation was detected with a Western blot assay. Furthermore, xenograft tumour models were established and tumour growth was recorded. Ki‐67 expression patterns and apoptosis were detected with immunohistochemistry and TUNEL, respectively. In vitro, Ginsenoside Rh1 repressed AGS cell proliferation, migration, and invasion, and further promoted apoptosis, with a concentration of 50 μM Rh1 exerting the equivalent effects as OXA. In vivo, Ginsenoside Rh1 inhibited GC proliferation and induced tumour cell apoptosis. Mechanistically, Ginsenoside Rh1 reduced TGF‐β1 and TGF‐β2 levels and Smad2 and Smad3 phosphorylation levels. Collectively, our findings highlighted that ginsenoside Rh1 inhibited GC cell growth and tumour growth in xenograft tumour models via inhibition of the TGF‐β/Smad pathway.
Workforce Diversity, Diversity Charters and Collective Turnover: Long‐term Commitment Pays
Authors: Chapman Gary , Nasirov Shukhrat , Özbilgin Mustafa 
Published: August 2022

AbstractModern workplaces are becoming increasingly demographically diverse. However, the influence of workforce diversity on organizational outcomes is not fully understood. In this work, we study how and why workforce gender and racial diversity impacts collective turnover at the organizational level, and whether participation in and experience with diversity charters moderate this link. We particularly argue that greater workforce gender and racial diversity leads to greater collective turnover because it prompts social categorization and negative contagion in organizations. To mitigate these processes, organizations may participate in diversity charters, which are expected to provide support with managing workforce diversity and employee retention. We further argue that the influence of diversity charters follows a trajectory of maturity, so their benefits are magnified as an organization's experience with them increases. Drawing on a panel of UK universities, we find strong evidence that greater workforce racial diversity is associated with higher levels of collective turnover, but only weaker evidence for the positive link between workforce gender diversity and collective turnover. We further find that diversity charters may attenuate this link, but simply participating in them is not sufficient: instead, organizations must develop experience with charters over time.
Time‐resolved transcriptome analysis of Scenedesmus obliquusHTB1 under 10% CO2 condition
Authors: Zhang Mei , Wang Hualong , Chen Feng 
Published: August 2022

AbstractCertain microalgal species can grow under high CO2 concentrations providing potential for mitigating CO2 pollution in flue gas produced by power plants. Microalga Scenedesmus obliquus strain HTB1 was isolated from the Chesapeake Bay and grow rapidly in a high level of CO2. However, little is known about the molecular responses of HTB1 to high CO2 levels. Here, we investigated how HTB1 responds to 10% CO2 using the time‐resolved transcriptome analysis. Gene expression profiles indicated that HTB1 responds quickly (in 2 h) and becomes adaptive within 12 h when exposed to 10% CO2. Interestingly, certain genes of light‐harvesting, chlorophyll synthesis and carbon fixation (i.e. rbcS) were up‐regulated at 10% CO2, and these functional responses are consistent with the increased photosynthesis efficiency and algal biomass under 10% CO2. Nitrate assimilation was strongly enhanced, with amino acid biosynthesis and aminoacyl tRNA biosynthesis genes being markedly up‐regulated, indicating that HTB1 actively takes up nitrogen and accelerates protein synthesis at 10% CO2. Carbon metabolism including fatty acid biosynthesis and TCA cycle was enhanced at 10% CO2, supporting the earlier observation of increased lipid content of Scenedesmus sp. under high CO2 levels. Interestingly, key genes like RuBisCO (rbcL) and carbonic anhydrase in carboxysomes did not respond actively to 10% CO2, implying that exposure to 10% CO2 has little impact on the carbon concentrating mechanisms and CO2 fixation of the Calvin cycle. It appears that HTB1 can grow rapidly at 10% CO2 without significant metabolic changes in carbon fixation and ATP synthesis.
Safety and efficacy of microwave ablation for lung cancer adjacent to the interlobar fissure
Authors: Wang Nan , Xu Jingwen , Wang Gang , Xue Guoliang , Li Zhichao , Cao Pikun , Hu Yanting , Cai Hongchao , Wei Zhigang , Ye Xin 
Published: August 2022

AbstractBackgroundThis retrospective study aimed to assess the safety and efficacy of microwave ablation for lung tumors adjacent to the interlobar fissures.MethodsFrom May 2020 to April 2021, 59 patients with 66 lung tumors (mean diameter, 16.9 ± 7.7 mm; range, 6–30 mm) adjacent to the interlobar fissures who underwent microwave ablation at our institution were identified and included in this study. Based on the relationship between the tumor and the interlobar fissure, tumors can be categorized into close to the fissure, causing the fissure, and involving the fissure. The complete ablation rate, local progression‐free survival, complications, and associated factors were analyzed.ResultsAll 66 histologically proven tumors were treated using computed tomography‐guided microwave ablation. The complete ablation rate was 95.5%. Local progression‐free survival at 3, 6, 9, and 12 months were 89.4%, 83.3%, 74.2%, and 63.6%, respectively. The complications included pneumothorax (34.8%), pleural effusion (24.2%), cavity (18.2%), and pulmonary infection (7.6%). There were statistical differences in the incidence of pneumothorax, cavity, and delayed complications between the groups with and without antenna punctures through the fissure.ConclusionsMicrowave ablation is a safe and effective treatment for lung tumor adjacent to the interlobar fissure. Antenna puncturing though the interlobar fissure may be a potential risk factor for pneumothorax, cavity, and delayed complications.
Alcohol sales in Canadian liquor outlets as a predictor of subsequent COVID‐19 infection rates: a time‐series analysis
Authors: Stockwell Tim , Zhao Jinhui , Alam Fariha , Churchill Sam , Shi Yipu , Naimi Timothy 
Published: August 2022

AbstractAimsGovernment alcohol sales data were used to examine whether age 15+ per‐capita alcohol consumption (PCAC) (i) changed during COVID‐19 and (ii) predicted COVID‐19 infections 2–5 weeks later.DesignInterrupted time‐series analyses were applied to panels of data before and after COVID‐19 restrictions were introduced in Canada.Setting and participantsThe populations, aged 15+, of the provinces of Ontario (ON), British Columbia (BC) and Nova Scotia (NS), Canada.InterventionExpansion of home delivery options and hours of trading for liquor stores while restrictions on travel, social and economic activities were imposed by governments during COVID‐19 from 17 March 2020 until 29 March 2021.MeasurementsWeekly estimates of (i) age 15+ PCAC using sales data supplied by provincial government alcohol distributors for liquor stores, bars and restaurants, (ii) stringency of public health measures assessed by the Public Health Agency of Canada (PHAC) and (iii) new COVID‐19 infections reported by PHAC.FindingsPCAC increased by 7.10% (P = 0.013) during the pandemic versus previous years, with increased private liquor store sales partly offset by reduced bar/restaurant sales. Consumption was positively associated with stringency of public health measures. Weekly PCAC was positively associated with new COVID‐19 infections 2 weeks later (+6.34% for a one drink/week increase, P < 0.001). Lagged associations with COVID‐19 infections 2 or 3 weeks later were observed for PCAC from all sales channels, with larger effect sizes per standard drink/person/week increase for on‐premise outlets (+77.27% week 2, P = 0.009) than government liquor stores (+6.49%, week 2, P < 0.001) or private liquor stores (+7.13%, week 4, P < 0.001).ConclusionsAlcohol consumption increased in three Canadian provinces during COVID‐19 to degrees corresponding to the extent of the strictness of measures imposed to prevent viral spread. Increased consumption of alcohol was associated with increased COVID‐19 infection rates 2 weeks later.
Trends in mental health service utilisation by Australia's older population
Authors: Bartholomaeus Jonathan D. , Collier Luke R. , Lang Catherine , Cations Monica , Kellie Andrew R. , Inacio Maria C. , Caughey Gillian E. 
Published: August 2022

AbstractObjectivesTo examine the incidence, trends, and differences between age groups and sex in Medicare Benefits Schedule (MBS)‐subsidised mental health service utilisation by older Australians over the past 10 years.MethodsA cross‐sectional cohort study between 1 July 2009 and 30 June 2019 was conducted using publicly available MBS data for older individuals aged ≥65 years. Age‐ and sex‐standardised yearly incidence rates of psychological therapy (MBS M06), GP mental health treatments (MBS A20), focussed psychological strategy (MBS M07), and psychiatric attendances (MBS A08) and incidence rate ratios (IRR) estimated using Poisson regression were calculated.ResultsOverall, the rate of utilisation of primary care mental health services by the older population increased over the study period, with psychological therapy claims increasing the greatest from 14.4/1000 older persons in 2009/10 to 38.5/1000 in 2018/19 (IRR 1.11, 95% CI 1.09–1.13), followed by GP mental health treatments increasing from 43.7/1000 (95% CI 43.4–43.9) in 2009/10 to 81.0/1000 (95% CI 80.7–81.3) in 2018/19 (IRR 1.07/year, 95% CI 1.06–1.09). Females aged 65–74 years had the highest use of GP mental health treatments at 123.8/1000 compared to 63.6/1000 in males in 2018/2019.ConclusionsWhile utilisation of mental health services by the older population in Australia has increased over the study period, it is important that policymakers and service providers continue to support access and use of these services, which may facilitate well‐being and quality of life in the older population.
Drug hypersensitivity, in vitro tools, biomarkers, and burden with COVID‐19 vaccines
Authors: Palomares Francisca , Paris Juan L. , Labella Marina , Doña Inmaculada , Mayorga Cristobalina , Torres María José 
Published: August 2022

AbstractHypersensitivity reactions to drugs are increasing worldwide. They display a large degree of variability in the immunological mechanisms involved, which impacts both disease severity and the optimal diagnostic procedure. Therefore, drug hypersensitivity diagnosis relies on both in vitro and in vivo assessments, although most of the methods are not well standardized. Moreover, several biomarkers can be used as valuable parameters for precision medicine that provide information on the endotypes, diagnosis, prognosis, and prediction of drug hypersensitivity development, as well on the identification of therapeutic targets and treatment efficacy monitoring. Furthermore, in the last 2 years, the SARS‐CoV‐2 (severe acute respiratory syndrome‐coronavirus) pandemic has had an important impact on health system, leading us to update approaches on how to manage hypersensitivity reactions to drugs used for its treatment and on COVID‐19 (Coronavirus disease) vaccines used for its prevention. This article reviews recent advances in these 3 areas regarding drug hypersensitivity: in vitro tools for drug hypersensitivity diagnosis, recently identified biomarkers that could guide clinical decision making and management of hypersensitivity reactions to drugs and vaccines used for COVID‐19.
Prophylactic onlay mesh at emergency laparotomy: promising early outcomes with long‐acting synthetic resorbable mesh
Authors: Alsaadi Daniah , Stephens Ian , Simmons Lydia O. , Bucholc Magda , Sugrue Michael 
Published: August 2022

AbstractBackgroundCareful surgical strategy is paramount in balancing the prevention of fascial dehiscence, incisional hernia (IH) and fear of additional mesh‐related wound complications post‐laparotomy. This study aims to review early outcomes of patients undergoing an emergency laparotomy with prophylactic TIGR® mesh, used to reduce early fascial dehiscence and potential subsequent IH.MethodA retrospective, ethically approved review of 24 consecutive patients undergoing prophylactic TIGR® mesh placement during emergency laparotomies by a single surgeon between January 2017 and June 2021 at a University Hospital. A standardized approach included onlay positioning of the mesh, small‐bite fascial closure, and a wound bundle. We recorded patient demographics, operative indications, findings, degree of peritonitis, postoperative complications, and mortality.ResultThe study included 24 patients; 16/24 (66.6%) were female and median age was 72.5 (range 31–86); 14/24 patients were ASA grade III or greater; 4/24 patients (16.6%) developed six complications and 3/6 occurred in a single patient. Complications included subphrenic abscess, seroma, intrabdominal hematoma, enterocutaneous fistula leading to deep wound infection and small bowel perforation. Five (20.8%) patients died in hospital; central venous catheter sepsis (n = 1), fungal septicaemia (n = 1) and multiorgan failure (n = 3). Surgical site infection and seroma rates were low, occurring in 2/24 patients (4% each).ConclusionThis study has identified that prophylactic onlay mesh in patients undergoing an emergency laparotomy is not associated with significant wound infection or seroma when used with an active wound bundle. The wider use of TIGR® to prevent fascial dehiscence and potential long‐term IH prevention should be considered.
Microbiology of surgical site infections (SSIs) following skin cancer surgery
Authors: Goh Maple F. , Hollewand Clare E. , McBride Stephen , Mathy Jon A. 
Published: August 2022

AbstractBackgroundsSurgical site infections (SSIs) represent one of the most common and potentially preventable sources of morbidity and healthcare cost escalation associated with skin cancer surgery. There is a lack of data reporting organisms cultured from SSIs in skin surgery, with guidelines for antibiotic prophylaxis based on common skin pathogens rather than actual cultured organisms. In this study, we sought to define the cultured microbiology of SSIs specific to skin cancer surgery and test these against empiric treatment guidelines.MethodsAll consenting patients presenting to the Auckland regional skin cancer treatment centre over a 6‐month period were included. Patients receiving any form of antibiotics within a week prior to surgery were excluded. All wounds were assessed postoperatively, with clinically significant infections identified as those with a standardized wound infection score of 4 (range 0–7) and/or prescribed post‐operative antibiotics within 3 weeks of surgery. Wound cultures were recorded.ResultsAbout 104 clinically significant SSIs were identified from 333 lesions treated, with cultures available in 27%. Cultured organisms included MSSA (79%), MRSA (14%), coagulase‐negative Staphylococci (11%), and ‘skin flora’ (14%). Empiric guidelines inaccurately predicted effective treatment in 14% of cases, exclusively due to MRSA.ConclusionTo our knowledge this is the first comprehensive report of SSI microbiology following skin cancer surgery. The overwhelmingly predominant organisms were Staphylococcus sp. (76%), with the rate of MRSA approaching prevalence warranting empiric first‐line treatment. These data help inform effective rationalized empiric antibiotic treatment, when indicated, for optimal outcome following skin surgery.
“What are my options?”: Physicians as ontological decision architects in surgical informed consent
Authors: Chen Stacy S. , Das Sunit 
Published: August 2022

AbstractThe aim of a theoretically ideal process of informed consent is to promote the autonomy of the patient and to limit unethical physician paternalism. However, in practice, the nature of the medical profession requires physicians to act as ontological decision architects—based on the medical knowledge that they acquire through their experience and training, physicians ontologically determine a subset of viable courses of action for their patient. What is observed is not an unethical physician limitation or biasing of the patient towards certain treatment options that violates patient autonomy or consciously undermines informed consent, but rather a more foundational paternalism that is necessarily inherent to the physician–patient relationship. In this article we argue for a recognition of this underlying physician paternalism and posit that this necessary paternalism is not a foil to patient autonomy, but rather a foundational aspect of the duties of the medical professional within the physician–patient relationship.