bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inclusionary Trials: A Review of Lessons Not Learned
Authors: Adkins-Jackson Paris B , Burke Nancy J , Espinosa Patricia Rodriguez , Ison Juliana M , Goold Susan D , Rosas Lisa G , Doubeni Chyke A , Brown Arleen F ,   The STOP COVID-19 California Alliance Trial Participation and Vaccine Hesitancy Working Groups
Published: September 2022

AbstractThe COVID-19 pandemic revealed weaknesses in the public health infrastructure of the United States, including persistent barriers to engaging marginalized communities toward inclusion in clinical research, including trials. Inclusive participation in clinical trials is crucial for promoting vaccine confidence, public trust, and addressing disparate health outcomes. A long-standing body of literature describes the value of community-based participatory research in increasing marginalized community participation in research. Community-based participatory research emphasizes shared leadership with community members in all phases of the research process, including in the planning and implementation, interpretation, and dissemination. Shared leadership between academic and industry with marginalized communities can assist with inclusive participation in vaccine trials and increase public trust in the development of the vaccines and other therapies used during public emergencies. Nevertheless, epidemiologic and clinical research do not yet have a strong culture of community partnership in the scientific process, which takes time to build and therefore may be difficult to develop and rapidly scale to respond to the pandemic. We outline practices that contribute to a lack of inclusive participation and suggest steps that trialists and other researchers can take to increase marginalized communities’ participation in research. Practices include planning for community engagement during the planning and recruitment phases, having regular dialogues with communities about their priorities, supporting them throughout a study, and navigating complex structural determinants of health. Additionally, we discuss how research institutions can support inclusive practices by reexamining their policies to increase participation in clinical trials and instilling institutional trustworthiness.
Nuclear envelope protein lamin B receptor protects the genome from chromosomal instability and tumorigenesis
Authors: Patil Shalaka , Deshpande Shruti , Sengupta Kundan 
Published: September 2022

AbstractLamin B Receptor (LBR) is an inner nuclear membrane protein that assembles the nuclear envelope post mitosis. Here we show that LBR depletion induces mitotic defects accompanied by recurrent chromosomal losses. In addition, LBR knockdown results in nuclear aberrations such as nuclear blebs and micronuclei, with chromosomes showing higher frequency of losses, being enriched within the micronucleus. Furthermore, doxycycline-induced conditional depletion of LBR significantly increased tumor volumes that form within the subcutaneous xenografts of mice. Of note, the tumor-derived primary cells recapitulated chromosomal losses and gains, revealing a novel role for LBR as a tumor suppressor. Co-immunoprecipitation of LBR uncovered an association of LBR with telomere-associated factors. Interestingly, qPCR array-based gene expression profiling showed a significant upregulation of telomere repeat-binding factor 1 (TRF1) upon LBR depletion. Remarkably, TRF1 knockdown in the background of LBR depletion maintains chromosomal stability, unraveling a novel mechanism involving LBR and TRF in the maintenance of chromosomal stability in colorectal cancer cells.
Comparable Outcomes for Bebtelovimab and Ritonavir-Boosted Nirmatrelvir Treatment in High-Risk Patients With Coronavirus Disease-2019 During Severe Acute Respiratory Syndrome Coronavirus 2 BA.2 Omicron Epoch
Authors: Razonable Raymund R , O’Horo John C , Hanson Sara N , Arndt Richard F , Speicher Leigh L , Seville Teresa A , Hall Scott T , Pike Marsha L , Heyliger Alexander , Larsen Jennifer J , Ganesh Ravindra , Tulledge-Scheitel Sidna M 
Published: September 2022

Abstract
The effectiveness of bebtelovimab in real-world settings has not been assessed. In this retrospective cohort study of 3607 high-risk patients, bebtelovimab was used more commonly than nirmatrelvir-ritonavir for treatment of coronavirus disease 2019 (COVID-19) among older patients, immunosuppressed patients, and those with multiple comorbid conditions. Despite its use in patients with multiple comorbid conditions, the rate of progression to severe disease after bebtelovimab (1.4% [95% confidence interval, 1.2%–1.7%]) was not significantly different from that for nirmatrelvir-ritonavir treatment (1.2% [.8%–1.5%]). Our findings support the emergency use authorization of bebtelovimab for treatment of COVID-19 during the Omicron epoch dominated by BA.2 and subvariants.
Social License and CSR in Extractive Industries: A Failed Approach to Governance
Authors: Akporiaye Alero , Webster D G 
Published: September 2022

AbstractWe examine the spread and persistence of corporate social responsibility (CSR) to mitigate oil conflict, despite its failures. Our work challenges the ideas versus interests debate, arguing for a third way in which reinforcing feedbacks between ideas (problem narratives) and interests (power disconnects) interact to shape the persistence of failed CSR. Using Ogoniland, Nigeria, as a case study, we present novel findings showing that Shell and the Nigerian government developed problem narratives for CSR that reinforces rather than narrows existing power disconnects. In contrast, as those most negatively affected by oil extraction, the Ogoni people have a more complex understanding of the problems associated with extraction and the necessary solutions. Therefore, they are disappointed with failed CSR applications practiced by Shell since 1997 and continue to protest ongoing impacts of oil extraction. Oil companies need to change their problem narratives and concede more power to communities, and governments should cease enabling failed CSR strategies. Additionally, governments should reflect on and address the role they play in enabling CSR as a failed strategy, whether they are oil-producing host countries such as Nigeria or oil-consuming home countries such as Holland. Last, we discuss the generalizability of our theoretical framework and propose that the international community could play a role in narrowing domestic power disconnects.
Troubled Comparative Trajectories and the Statistical Construction of Disempowered Arab and Muslim Women Subjects
Authors: Jamal Manal A 
Published: September 2022

AbstractSince 9/11, a number of scholars added gender as a new variable to explain how economic, political, and/or social developments in the Middle East have diverged from developments elsewhere. These studies relied almost exclusively on statistical analysis and frequently discounted much of the extant literature, especially the more feminist and historically sensitive and in-depth qualitative works on the subject matter. Almost uniformly, the point of departure for many of these works was the disempowered socioeconomic and/or political status of Arab/Muslim women. Most of the scholars of these works had no gender expertise and had never written on women previously. Regardless, these works spawned an important discussion in the field of comparative politics and their scholarly impact has been noteworthy. Such scholarship, however, is not benign.Accordingly, this article seeks to answer two critical questions: How does the work of non-gender specialists of Middle East and North Africa (MENA) come to have such a significant impact on the study of women and politics in the field of comparative politics? How can we approach these research inquiries differently so that expertise, lived realities, and history matter? The article argues that feminist international relations could serve as a critical corrective to this current trajectory of comparative politics research. This corrective also requires a commitment to feminist scholarship that begins with women's lives and seeks to eliminate gender inequality, as well as greater understanding of the composition and changing structure of our disciplinary communities.
Intestinal Microflora Characteristics ofAntheraea pernyi(Lepidoptera: Saturniidae) Larvae With Vomit Disease
Authors: Jia Shu , Zhang Juntao , Li Xisheng , He Yingzi , Yu Tinghong , Zhao Chong , Song Ce 
Published: September 2022

AbstractAntheraea pernyi Guérin-Méneville (Lepidoptera: Saturniidae) is of high economic value as a source of silk, food, and bioactive substances with medicinal properties. A. pernyi larvae are prone to A. pernyi vomit disease (AVD), which results in substantial economic losses during cultivation; however, the relationship between AVD and A. pernyi gut microbiota remains unclear. Here, we investigated the bacterial community in the midgut and feces of A. pernyi larvae with and without AVD using 16S rRNA gene sequencing with Illumina MiSeq technology. Compared with healthy larvae, intestinal bacterial diversity and community richness increased and decreased in larvae with mild and severe AVD, respectively. In addition, the proportion of gut Enterobacter Hormaeche and Edwards(Enterobacteriales: Enterobacteriaceae) and Enterococcus Thiercelin and Jouhaud (Lactobacillales: Enterococcaceae) was higher and lower, respectively, in larvae with mild AVD than those in healthy larvae. A. pernyi vomit disease infection significantly increased the genera with abundance &lt;1%. In the gut of larvae with severe AVD, the proportion of Turicibacter Bosshard et al. (Erysipelotrichales: Turicibacteraceae) increased significantly to 81.53–99.92%, whereas that of Enterobacter decreased compared with healthy larvae. However, the diversity of fecal bacteria was similar between healthy larvae and those with mild AVD. Overall, the findings demonstrate that intestinal microflora in A. pernyi larvae are altered by AVD infection and may cause secondary bacterial infection. This is the first report of the presence of Turicibacter in the intestinal tract of lepidopterans.
Spoken language identification based on the transcript analysis
Authors: Lande Dmytro V , Dmytrenko Olegh O , Shevchenko Anatolij I , Klymenko Mykyta S , Vakulenko Maksym O 
Published: September 2022

Abstract
Language identification is a great challenge in language engineering, which arises along with the tasks of speech recognition, machine translation, cross-language information retrieval, intelligent dialogue system creation, etc. The presented article introduces the intelligent language identification technology, which is based on speech recognition and statistical methods of spectrogram analysis. The approach to the automatic identification of the spoken language sample uploaded to the system, in particular from video streaming services such as YouTube, is put forward. The article focuses on the automatic identification of spoken language, taking into account several speech recognition solutions for correct or incorrect speech recognition and its conversion into correct or incorrect text. The obtained algorithm is demonstrated in the Ukrainian and Russian languages. The identification quality of the language of an utterance, which lasts &gt;30 s is almost 100%, and for the utterance of a duration of 30 s, the quality is 98%, and for the 5-s utterance, it reaches 89.6%. In addition to that, the system performance is contingent on the streaming speed, so it is a real-time system.
S1.4d Cryptococcus qPCR assays: the future for routine mycology labs and clinical trials dealing with cryptococcosis
Authors: Mbangiwa Tshepiso , Sturny-Leclère Aude , Lechiile Kwana , Kajanga Cheusisime , Chammard Timothée Boyer , Lortholary Olivier , Dromer Francoise Dromer , Hoving Jennifer C. , Lawrence David S. , Mwandumba Henry , Mosepele Mosepele , Harrison Tom , Jarvis Joseph N , Alanio Alexandre 
Published: September 2022

Abstract

S1.4 Fungal infections in Asia, bringing it out of the dark, September 21, 2022, 11:00 AM - 12:30 PM

Background
Routine laboratory testing for cryptococcal meningitis currently consists of Cryptococcal antigen (CrAg) testing in blood and cerebrospinal fluid (CSF), CSF India ink, and CSF fungal culture. Quantitative cryptococcal culture (QCC) is labor intensive and not feasible in most settings.

Objectives
We evaluated quantitative (qPCR) and reverse transcriptase qPCR (RT-qPCR) assays to quantify cryptococcal load in CSF, plasma, and blood. We also investigated the dynamics of fungal DNA and RNA detection during antifungal treatment.

Methods
We developed a qPCR assay that can differentiate serotypes A, D, and B/C of Cryptococcus neoformans and C. gattii based on the amplification of a unique nuclear Quorum sensing protein 1 (QSP1) and a multicopy 28S rRNA gene and evaluated the assays on 205-patient samples from the AMBITION-cm trial in Botswana and Malawi (2018-2021). CSF, plasma, and whole blood samples were stored per patient and were sampled at day 0 (baseline), day 7 and 14 for CSF and at day 1, 3 and 7 for plasma and whole blood post antifungal treatment initiation. A Roche LightCycler480 and Graph pad prism were used for data analysis.

Results
A total of 205/209 stored patient samples (85 from Botswana; 124 from Malawi), were used. For QSP1 qPCR tested in CSF at D0, 138 (81.7%) were serotype A, 28 (16.6%) were serotype B/C and 3 (1.8%) were a mixed infection of serotype A and B/C. There was no amplification with 36 (17.6%) samples. There was no difference in fungal loads at D0, D7, and D14 between serotype A and B/C with the QSP1 qPCR assay, and QCC. QCC showed a good correlation with qPCR quantification with QSP1 qPCR (slope = 0.797, R2 = 0.73) and with 28S rRNA qPCR (Slope = 0.771, R2 = 0.778) assays. The fungal load at D0 was significantly higher in patients who died at week 2 (w2) and at week 10 (w10) as compared with patients who survived post-week 10 (P &lt;.01), with no significant difference in initial fungal load in both treatment regimens (P &gt;.05). Detection of Cryptococcus DNA (28S rRNA qPCR) in plasma or whole blood within the first 24 h of treatment was significantly associated with early mortality at w2 and mortality at w10 (P &lt;.01). QSP1 RT-qPCR showed that detection of DNA was due to viable fungal cells as the quantification of QSP1 whole nucleic acids was systematically higher (X2 to 5) than that of DNA.

Conclusion
Quantification of C. neoformans and C. gattii load in CSF and plasma at D0 is useful in identifying patients at risk of death and may be a promising tool for monitoring treatment response in the future.
Intermediate-mass black holes and the Fundamental Plane of black hole accretion
Authors: Gültekin Kayhan , Nyland Kristina , Gray Nichole , Fehmer Greg , Huang Tianchi , Sparkman Matthew , Reines Amy E , Greene Jenny E , Cackett Edward M , Baldassare Vivienne 
Published: September 2022

ABSTRACT
We present new 5 GHz Very Large Array observations of a sample of eight active intermediate-mass black holes with masses 104.9 M⊙ &lt; M &lt; 106.1 M⊙ found in galaxies with stellar masses M* &lt; 3 × 109 M⊙. We detected five of the eight sources at high significance. Of the detections, four were consistent with a point source, and one (SDSS J095418.15+471725.1, with black hole mass M &lt; 105 M⊙) clearly shows extended emission that has a jet morphology. Combining our new radio data with the black hole masses and literature X-ray measurements, we put the sources on the Fundamental Plane of black hole accretion. We find that the extent to which the sources agree with the Fundamental Plane depends on their star-forming/composite/active galactic nucleus (AGN) classification based on optical narrow emission-line ratios. The single star-forming source is inconsistent with the Fundamental Plane. The three composite sources are consistent, and three of the four AGN sources are inconsistent with the Fundamental Plane. We argue that this inconsistency is genuine and not a result of misattributing star formation to black hole activity. Instead, we identify the sources in our sample that have AGN-like optical emission-line ratios as not following the Fundamental Plane and thus caution the use of the Fundamental Plane to estimate masses without additional constraints, such as radio spectral index, radiative efficiency, or the Eddington fraction.
Study of correlation between optical flux and polarization variations in BL Lac objects
Authors: Rajput Bhoomika , Pandey Ashwani , Stalin C S , Mathew Blesson 
Published: September 2022

ABSTRACT
Polarized radiation from blazars is one key piece of evidence for synchrotron radiation at low energy, which also shows variations. We present here our results on the correlation analysis between optical flux and polarization degree (PD) variations in a sample of 11 BL Lac objects using ∼10 yr of data from the Steward Observatory. We carried out the analysis on long-term (∼several months) as well as on short-term time-scales (∼several days). On long-term time-scales, for about 85 per cent of the observing cycles, we found no correlation between optical flux and PD. On short-term time-scales, we found a total of 58 epochs with a significant correlation between optical flux and PD, where both positive and negative correlation were observed. In addition, we also found a significant correlation between optical flux and γ-ray flux variations on long-term time-scales in 11 per cent of the observing cycles. The observed PD variations in our study cannot be explained by changes in the power-law spectral index of the relativistic electrons in the jets. The shock-in-jet scenario is favoured for the correlation between optical flux and PD, whereas the anticorrelation can be explained by the presence of multizone emission regions. The varying correlated behaviour can also be explained by the enhanced optical flux caused by the newly developed radio knots in the jets and their magnetic field alignment with the large-scale jet magnetic field.
Unsupervised clustering and analysis of WISE spiral galaxies
Authors: Guo Xiaoyu , Liu Cuixiang , Qiu Bo , Luo A-li , Jiang Xia , Shi Jinghang , Li Xiaotong , Wang Linqian 
Published: September 2022

ABSTRACT
The Wide-Field Infrared Explorer (WISE) survey captured massive amounts of infrared astronomical object data, and different astronomical objects will show different characteristics. Especially spiral galaxies that are richer in colour than other astronomical objects. In addition, the Sloan Digital Sky Survey (SDSS) has obtained a large number of visible light images and their parameter. So this paper mainly explores the colour characteristics of WISE spiral galaxies, and uses SDSS, 2MASS, WISE, and MANGA parameters to analyse the differences between different classes and the commonality of the same class, so that provides help for astronomers to study infrared spiral galaxies. First, the RA and Dec. of the spiral galaxy samples were crossed in GalaxyZoo2. The flux data of w1, w2, and w3 bands in WISE were crossed for image synthesis. The Bootstrap Your Own Latent contrastive learning framework and K-means clustering were used to unsupervised classify the infrared spiral galaxy images. After multiple experiments, five classes of images were selected by referring to the best clustering results. Finally, the parameter of galaxies in SDSS, 2MASS, WISE, and MANGA catalogues were crossed, including redshift, 12 magnitudes that from visible light band to mid-infrared band, stellar formation rate, stellar metallicity, stellar velocity dispersion, etc. These parameters were qualitatively and quantitatively analyzed. The effectiveness of unsupervised clustering algorithms for handling unlabeled data is demonstrated and two special classes of galaxies are found. The analysis result shows that the distribution characteristics of different parameters of different classes of infrared spiral galaxies are different.
Gas-phase spectroscopy of photostable PAH ions from the mid- to far-infrared
Authors: Wiersma Sandra D , Candian Alessandra , Bakker Joost M , Petrignani Annemieke 
Published: September 2022

ABSTRACT
We present gas-phase InfraRed Multiple Photon Dissociation (IRMPD) spectroscopy of cationic phenanthrene, pyrene, and perylene over the 100–1700 cm−1 (6–95 μm) spectral range. This range covers both local vibrational modes involving C–C and C–H bonds in the mid-IR, and large-amplitude skeletal modes in the far-IR. The experiments were done using the 7T Fourier-Transform Ion Cyclotron Resonance (FTICR) mass spectrometer integrated in the Free-Electron Laser for Intra-Cavity Experiments (FELICE), and findings were complemented with Density Functional Theory (DFT) calculated harmonic and anharmonic spectra, matching the experimental spectra well. The experimental configuration that enables this sensitive spectroscopy of the strongly bound, photoresistant Polycyclic Aromatic Hydrocarbons (PAHs) over a wide range can provide such high photon densities that even combination modes with calculated intensities as low as 0.01 km mol−1 near 400 cm−1 (25 μm) can be detected. Experimental frequencies from this work and all currently available IRMPD spectra for PAH cations were compared to theoretical frequencies from the NASA Ames PAH IR Spectroscopic Database to verify predicted trends for far-IR vibrational modes depending on PAH shape and size, and only a relatively small redshift (6–11 cm−1) was found between experiment and theory. The absence of spectral congestion and the drastic reduction in bandwidth with respect to the mid-IR make the far-IR fingerprints viable candidates for theoretical benchmarking, which can aid in the search for individual large PAHs in the interstellar medium.
Signatures of extended discs and outflows in the circumgalactic medium using the Q0107 quasar triplet
Authors: Beckett Alexander , Morris Simon L , Fumagalli Michele , Tejos Nicolas , Jannuzi Buell , Cantalupo Sebastiano 
Published: September 2022

ABSTRACT
We use H i absorption along the lines-of-sight to the Q0107 quasar triplet in order to model potential disc and outflow structures in the circumgalactic medium of intervening galaxies at z ≲ 1, as well as the intergalactic medium on scales of up to a few virial radii. We consider a sample of twelve isolated galaxies in the Q0107 field with position angles and inclinations measured from HST imaging as well as redshifts from our spectroscopic surveys, alongside 27 detected Ly α absorbers within 500 km s−1 of these galaxies. Building on previous work showing increased incidence of absorption close to the projected major and minor axes, we use model rotating discs and bi-conical outflows in attempting to reproduce the observed absorption. Requiring these models to match absorption in multiple lines-of-sight provides additional constraints over single-sightline observations. We identify four possible outflows with velocities ∼100 km s−1, two of which extend to or beyond the virial radius, with a variety of opening angles. Two galaxies have nearby co-rotating absorbers with rotation velocities ≲ vvir, that may probe disc-like structures, and we can rule out a disc/outflow origin for a further ten absorbers. These indicate that outflowing and co-rotating structures can extend to large scales but are either not ubiquitous, or do not always produce detectable Ly α. In some cases, disc models are successful even close to the minor axis of the galaxy, and some of our model outflows exhibit wide opening angles. These results imply that purely geometrical cuts are not sufficient to distinguish between discs and outflows in single line-of-sight studies.