bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate change and mental health: An overview
Authors: Erfurth A. , Sachs G. 
Published: February 2022

According to the UN Environment Programme “climate change is one of the most pervasive and threatening issues of our time”. “In many places, temperature changes and sea-level rise are already putting ecosystems under stress and affecting human well-being” (1). The presentation wants to give an overview on how climate change can affect mental health. A search was performed on PubMed for the combination of “climate change” and “mental health”. 281 publications were identified, the first being from 2007 (the only one in that year). In 2020, until Dec 22nd, 76 publications were found. The somehow prophetic 2007 publication reviews “natural disasters, climate change and mental health considerations for rural Australia” (2) and pinpoints central aspects of today’s debate, namely anxiety and depression, vulnerability and resilience. In addition to problems of rural areas (2), the impact of urbanicity (3) will be discussed as well as the role of air pollution on psychiatric disorders (4). (1) UN Environment Programme. https://www.unenvironment.org/explore-topics/climate-change/about-climate-change Dec 22nd, 2020. (2) Morissey SA, Reser JP. Aust J Rural Health. 2007 Apr;15(2):120-5. doi: 10.1111/j.1440-1584.2007.00865.x. (3) Krabbendam L et al. Psychol Med. 2020 Mar 11:1-12. doi: 10.1017/S0033291720000355. (4) Kim SY et al. Sci Total Environ. 2020 Dec 8;757:143960. doi: 10.1016/j.scitotenv.2020.143960.DisclosureNo significant relationships.
Prevalence of health anxiety in indian ophthalmologists during COVID-19: a survey
Authors: K C. 
Published: February 2022

IntroductionMental health concerns are common in health care workers during pandemic. There are no studies of the prevalence of health anxiety in ophthalmologists in India.ObjectivesTo estimate the prevalence of health anxiety in ophthalmologists practicing in India during the ongoing pandemic.MethodsA questionnaire-based online survey on the “changes and challenges during COVID-19” using Google forms was sent to all members of the All India Ophthalmological Society. Besides demographics, the survey had questions to assess the general mental and medical health status of the ophthalmologists. Short Health Anxiety Inventory (SHAI) was used to assess health anxiety.Results
1027 ophthalmologists responded to the study. Higher stress was experience by 83.1% compared to pre-COVID while examining patients closely (35.9%) or during surgery due to the risk of aerosol generation (29.3%). SHAI score >20 was observed in 5.6%. Only emergency services were being provided by 50% and 17% in the SHAI > 20 group were not working as compared to overall 14%.ConclusionsOur findings indicate that a majority of the ophthalmologists were under stress during the COVID-19 pandemic but only a small proportion experienced health anxiety. It is likely that mental health issues may arise among ophthalmologists in the foreseeable future.
The effect of childhood trauma and trauma-focused psychotherapy on blood expression in patients with major depressive disorder
Authors: Minelli A. , Maffioletti E. , Sacco C. , Magri C. , Zampieri E. , Cattaneo A. , Perusi G. , Mazzelli M. , Bortolomasi M. , Gennarelli M. 
Published: February 2022

The only available genome-wide study (Minelli et al., 2018) indicated an association between the neglect CT and MED22, a transcriptional factor gene. To verify how the dysregulation of MED22 could be affected by environmental and genetic factors, we carried out an analysis on these components and a longitudinal study concerning the effect of trauma-focused psychotherapy in MDD patients that experienced CT. On a large mRNA sequencing dataset including 368 MDD patients we computed the genetic (GReX) and the environmental (EReX) components affecting gene expression in relation to CT. Furthermore, we measured the expression of MED22 in 22 MDD patients treated with trauma-focused psychotherapy. The dissection of MED22 expression profiles revealed an association of neglect with environmental and genetic components (p=6x10-3 p=2.6x10-4). Furthermore, in an independent cohort of 177 controls, we also observed a significant association between cis-eSNPs of MED22 and higher neuroticism scores (best p-value: 0.00848) that are usually associated with a decreased amount of resilience to stress events. Finally, the results of psychotherapy revealed a reduction of depressive symptomatology (p<0.001) and 73% of patients resulted responders at the follow-up visit. MED22 expression during psychotherapy showed a change trend (p=0.057) with an interaction effect with response (p=0.035). Responder and non-responder patients showed MED22 expression differences at different trauma-focused psychotherapy timepoints (p=0.15; p=0.012) and at the follow-up (p=0.021). Our results provide insights suggesting that some biological and clinical consequences of CT depend on genetic background and environmental factors that could induce vulnerability or resilience to stressful life events.DisclosureNo significant relationships.
Barriers and facilitators associated with pharmacological treatment in bipolar disorder patients
Authors: Partera J.Á. Alcalá , Navas A. Fontalba , Morales M. Company , Guillena S.L. Romero , Higueras T. Gutiérrez , Cortés F. Calera , Forés S. Vicent , Rojas L. Gutiérrez 
Published: February 2022

IntroductionThe main factors that are involved in a correct adherence to the therapeutic recommendations in Bipolar Disorder includes aspects related to age, sex, ethnicity, socioeconomic level and characteristics of the illness associated with the severity, comorbidity and adverse effects related to previous medicine.ObjectivesTo analyse the individual perception that the patient with Bipolar Disorder has regarding the positive and negative aspects of taking the recommended medication.MethodsDescriptive and interpretative observational study under the qualitative paradigm of research, extracting the data through the completion of four focus groups with ten patients everyone. To complete the codification of the content of the participant’s discourses, we rely on the QRS NVivo 10 computer program.ResultsIn the participant’s discourse concerning the main barriers to pharmacological treatment, for example “It’s because we live in a society and, because of that, we don’t go without medicine; if we didn’t live in society, we wouldn’t take medicine because we wouldn’t bother anyone”. Some examples of patient’s discourse, about perceived facilitators were: “I have to take medicine for my bipolar disorder, that’s it, I have a treatment, my illness has a name”.ConclusionsThe main facilitators regarding the use of pharmacological treatment in Bipolar Disorder are the perceived need for treatment in the acute phase and the recognition of the illness, the shared clinical decision and the causal biological attribution in the chronic phase. About perceived barriers, social control is identified in both phases, adverse effects in the acute cases and the absence of effective treatment in the chronic state.
Telomere attrition and inflammatory load in major depressive disorder
Authors: Squassina A. 
Published: February 2022

Patients with major depressive disorder (MDD) present features that suggest the involvement of accelerated aging, such as increased circulating inflammatory markers and shorter telomere length (TL). Here we measured T-lymphocytes TL with quantitative fluorescent in situ hybridization (Q-FISH) and plasma levels of inflammatory markers in a cohort of 37 patients with MDD and 36 non-psychiatric controls (C). TL was shorter in MDD compared to C (F=8.52, p=0.005). Patients with treatment resistant (TR) MDD showed higher levels of TNFα compared to non-TR (adjusted p= 0.034) and C (adjusted p=0.025), suggesting that treatment resistance might be associated with increased inflammation compared to non-TR.DisclosureNo significant relationships.
Circadian rhythm dysfunction in bipolar affective disorder
Authors: Valadas M.T. , Freitas R. Mota 
Published: February 2022

IntroductionSleep is paramount in bipolar affective disorder and sleep disturbance can be a trigger or initial manifestation of an episode of illness. Changes in the circadian rhythm in bipolar affective disorder have consistently been recognized and reported, however, this feature can be overlooked in daily clinical practice.ObjectivesWe aim to review and summarize the literature regarding changes in circadian rhythm in patients with bipolar affective disorder.Methods
We performed an updated review in the PubMed database using the terms “circadian rhythm” and “bipolar affective disorder”.Results
Irregularity of the sleep–wake rhythm, eveningness chronotype, abnormality of melatonin secretion, vulnerability of clock genes, and the irregularity of social time cues are circadian rhythm markers disrupted in bipolar affective disorder. Circadian rhythm dysfunction might be a trait marker of this illness and can act as a predictor for the first onset of bipolar affective disorder and the relapse of mood episodes. Achieving normalization of circadian rhythm in combination with pharmacological, psychosocial and chronobiological treatments can be a tool for managing bipolar affective disorder.Conclusions
Recognizing patterns of changes in circadian rhythms is important to detect and diagnose bipolar disorder in clinical practice, also affecting treatment. These alterations are often overlooked and can lead to inadequate treatment and management.
Spirituality and quality of life among bipolar disorder patients
Authors: Ajmi S. , Sellami R. , Najjar S. , Masmoudi R. , Feki I. , Masmoudi J. 
Published: February 2022

IntroductionQuality of life is a broad and complex concept, but essentially refers to an individual’s well-being in a spectrum of life domains.ObjectivesThe aim of the present study was to investigate the relationship between spirituality, religiosity (S/R) and quality of life (QOL) among bipolar disorder (BD) patients.Methods
Data were collected between July and December 2017.Participants were enrolled from the Mood Consultation of the Psychiatry (A) Department of the University Hospital HediChaker. We assessed symptoms of mania [Young Mania Rating Scale (YMRS)], depression [Beck scale], quality of life [World Health Organization Quality of Life-Brief Version (WHOQOL-BREF)]andquality of life aspects related to spirituality, religiousness and personal beliefs [World Health Organization Quality Of Life –Spirituality, Religiousness and Personal Beliefs (WHOQOL-SRPB)]Results
Our sample included 60 patients. It consisted of 55% of female and the mean age was 44.94 (SD=12.76). The sample included 68% of participant diagnosed with BDI and 32% with BDII The median score of quality of live was 3 (minimum=1; maximum=5).The median of physic, psychic, social and environmental quality of life was respectively (25, 31, 81 and 19) (Minimum=0; Maximum=100). The mean score of WHOQOL-SPRB was 14.82 (Minimum=4, Maximum=20). S/R were correlated to psychic, social and environmental quality of life (p=0.006, p=0.011, p=0.016). We did not find a significant association between physic quality of life and S/R (p=0.234).ConclusionsOur study suggests that spirituality, religiosity have an important influence on most aspects of the quality of life among bipolar patients.
Lithium placental passage at delivery and neonatal outcomes: A retrospective observational study
Authors: Imaz M.L. , Torra M. , Soy D. , Langorh K. , Garcia-Esteve L. , Martin-Santos R. 
Published: February 2022

Introduction
Lithium is an effective mood stabilizer and is widely used as a first-line treatment for bipolar disorder in the perinatal period. Several guidelines have provided clinical advice on dosing strategy (dose reduction versus stop lithium) in the peripartum period to minimize the risk of neonatal complications. An association has been observed between high neonatal lithium concentrations (> 0.64 mEq/L) and lower 1-min Apgar scores, longer hospital stays, and central nervous system and neuromuscular complications.ObjectivesTo quantify the rate of lithium placental passage at delivery. To assess any association between plasma concentration of lithium at delivery and neonatal outcome.Methods
In this retrospective observational cohort study, we included women treated with llithium at least in late pregnancy. Maternal (MB) and umbilical cord (UC) lithium blood level measurement were collected at delivery. Lithium serum concentrations were determined by means of an AVL 9180 electrolyte analyzer. The limit of quantification (LoQ) was 0.20 mEq/L and detection limit was 0.10 mEq/L. From the medical records, we extracted information on neonatal outcomes (preterm birth, birth weight, Apgar scores, pH-values, and admision to NICU) and complications categoriced by organ system: respiratory, circulatory, hematological, gastro-intestinal, metabolic, neurological, and immune system (infections).ResultsUmbilical cord and maternal lithium blood levels were strongly correlated: mean (SD) range UC/MR ratio 1.15 (0.24). Umbilical cord lithium levels ranged between 0.20 to 1.42 mEq/L. We observed no associations between umbilical cord lithium blood levels at delivery and neonatal outcomes.ConclusionsIn our study, newborns tolerated well a wide range of lithemias, between 0.20 and 1.42 mEq/L.
Prenatal attachment & socio-demographic and clinical factors
Authors: Meddouri L.S. , Bourgou S. , Fakhfakh R. , Bousnina D. , Triki A. , Belhadj A. 
Published: February 2022

IntroductionA pregnant woman’s bond with her fetus and the quality of the prenatal attachment can be determined by numerous variables.ObjectivesDetermine the socio-demographic and clinical factors’ effect on prenatal attachment.MethodsWe conducted a transversal descriptive study in a first line clinical practice center and in an university gynecology-obstetrics department. The Prenatal Attachment Inventory (PAI) was used to assess maternal-fetal attachment.ResultsFor the 125 pregnant women that participated in our study, 99,2% were married with consanguinity for 14,4%. The mean marriage duration was 4 years and 3 months. Women were illiterate in 3,2% and more than the half (54,4 %) were unemployed. On average, the current pregnancy was their second one. Pregnancy was spontaneous in 85,6%, unplanned in 71,2% and not desired in 29,6%. Sex of the fetus was not desired by the mother in 40,8%. Dysgravidia complicated 32% of the pregnancies with hospitalization in 25,6%. Fetal health problems were detected in 7,2%. A psychiatric trouble has been reported by 4% of the pregnancies. The total score of PAI ranged from 27 to 82 in our sample. We found a statistically significant negative correlation between PAI and duration of marriage (p=0,012); PAI and gestation number (p=0,039) ; and a correlation between PAI and the planning of the pregnancy (p=0,030).ConclusionsSocio-demographic and clinical factors should be taken in consideration while evaluating pregnant women at risk of perinatal psychological difficulties.Conflict of interestNo significant relationships.
Conditions of negation formation in children of early age with down syndrome
Authors: Sedova E. , Stepanova V. , Gardanova Z. 
Published: February 2022

Introduction
According to Vygotsky, children with special needs follow the same trajectory of development as normally developing children, although some of the skills can be observed in a later period. This statement can be implemeted to the children with Down syndrome. The number of such children in Russia is around 25 thousand.ObjectivesThe aim is to study the conditions of negation formation in children with Down syndrome.MethodsThe sample consisted of 22 dyads of children with Down syndrome of 24-36 months old and their mothers. The research methods included: parents’ questionnaire; analysis of problematic situations; Tkacheva’s inventory Parent’s Psychological Type; Varga &Stolin Inventory of Parental Attitude; Toronto Alexithymia Scale, Bass-Darky Hostility Questionnaire, Leonhard-Schmieschek Test, Spielberger’s Test Anxiety Inventory.Results
Firstly, we have studied how a child expresses his or her negative reaction: whether he or she uses a gesture or a sound for “no” or reacts with the whole body. According to those results we have divided the sample into two groups and then have compared them. The research shows the connection between mother’s aggressiveness and formation of the child’s negation reaction (gesture/sound or the whole body) as well as differences in the level of alexithymia and anxiety: all the characteristics are lower in the first group.ConclusionsMothers of the children with Down syndrome demonstrate a high and a medium level of anxiety. However, the mothers of the children who expresses negation with a gesture/sound show a lower anxiety level comparing with the mothers whose children react with the whole body.
Productivity of tasks performance in children and adolescents with different level of media multitasking
Authors: Koshevaya A. , Soldatova G. , Chigarkova S. 
Published: February 2022

IntroductionMedia multitasking (MMT) begins to play an increasingly important role in terms of the digitalization of everyday life. At the same time, the effect of MMT on efficiency is still poorly highlighted, especially among the younger generation (May, Elder, 2018; Patterson, 2017; Peifer, Zipp, 2019).ObjectivesThe aim is to identify types of MMT in children and compare them by productivity and time of task performance.Methods
Quasi-experimental research, which included the performance of tasks on a computer and a smartphone, was conducted among children in three groups aged 7-10 years, 11-13 years, 14-16 years (N=154).ResultsBased on a number of criteria, several types of behavior are identified in the MMT environment: two subgroups of “single-taskers” (23%), “light” (19%), “medium” (54%) and “heavy” (4%) MMT. Comparative analysis (p=0.027) reveals high scores for proper task performance of the subgroup “single-taskers1”, as well as “heavy” and “light” MMT. The other subgroup “single-taskers2” and “medium” MMT show, on the contrary, low productivity results. MMT groups also differ in terms of task performance time (p=0.006). The “light” and “heavy” MMT cope the fastest. The second place by the speed of task performance is held by “medium” MMTs and “single-taskers1”, and the slowest are “single-taskers2”.Conclusions
The results show that both linear and nonlinear behavioral strategies can lead to a certain level of performance. Most children try to operate in the MMT mode and it is becoming the dominant and ubiquitous modus vivendi for the younger generation. The reported study was funded by RFBR, project No. 19-29-14181.Conflict of interestThe reported study was funded by RFBR, project No. 19-29-14181.
Early premorbid of children with ASD
Authors: Kalinina M. , Shimonova G. 
Published: February 2022

IntroductionAccording to numerous studies, the origins of most endogenous mental diseases, in particular, autism, lie in early childhood. This concept is based on the classical theories of diathesis.ObjectivesThe purpose of this study was to clarify the phenomenology of mental disorders in children with an assessment of the prognostic significance of symptoms that preceded the development of the disease for future mental health.Methods
The clinical material was collected during the survey of a child population. Selected for prospective observation was 40 children (1-3 years old) from the high-risk group for schizophrenia with functional disorders of the endogenous spectrum. All patients were examined by clinical methods and pathopsychological, neurophysiological. Psychometric scales PANSS, CARS were used. The results were mathematically evaluated using the Statistica 7 program.ResultsThe clinical picture of the mental state of young children, in children with autistic disorders in 1,5-3 years, was determined by a specific complex of disorders, which were reduced to a general deficit, especially in the emotional sphere, vegetative dysregulation, most often, the sleep-Wake rhythm. Motor skills, as a rule, did not lag significantly behind the age standards. The onset of actual autistic disorders was noted older than 1 year of life. Сhildren received medication and corrective therapy. The detailed clinical picture of violations developed gradually. Dynamics of psychopathological picture in (80,0%) children was regressive.ConclusionsThe study shows the importance of preventive measures in people related to ASD, sparing individual approach in education and therapy.
Parental concerns during COVID-19-related school closures: Children’s behaviors and media usage
Authors: Kim S. , Shin Y. 
Published: February 2022

Introduction
While coronavirus disease 2019 (COVID-19) spreads across the globe, many countries have closed schools to ensure physical distancing to slow transmission and ease the burden on health systems. Concerns regarding Coronavirus Disease 2019 (COVID-19) school closures often increase stress levels in parents.Objectives
This study examined whether higher levels of parental concerns were associated with children’s problematic behaviors and other factors during COVID-19-related primary school closures.MethodsParticipants were 217 parents who responded to a web-based questionnaire covering parental concerns, subjective stress, and depression; children’s sleep patterns, behavioral problems, and changes in activity level after COVID-19; previously received mental health services; and media usage during the online-only class period from community center in Suwon city.ResultsThe number of parental concerns was associated with children’s behavioral problem index (BPI) score (Pearson correlation 0.211, p < 0.01), sleep problems (0.183, p < 0.01), increased smartphone usage (0.166, p < 0.05), increased TV usage (0.187, p < 0.01), parents’ subjective stress levels (0.168, p < 0.05), and parental depression (0.200, p < 0.01). In families with children who previously received mental health services, the children reportedly suffered from more sleep and behavioral problems but not increased media usage, and parents noted more stress and depression. Parental concerns are related to family factors such as change of caregiver, no available caregiver, decreased household income, and recent adverse life events.ConclusionsOngoing monitoring of mental health at risky group and multiple support systems should be considered for parents having difficulty in caring their children.