bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topologically Protected Plasmonic Phases in Randomized Aperture Gratings
Authors: Fox Maayan , Gorodetski Yuri 
Published: December 2022

Abstract
We experimentally show the excitation of surface plasmons by topologically protected diffraction from gratings with randomized periodicity. The structures are designed such that the plasmonic excitation is conditioned by the proper combination of the geometric and the dynamic phases. Accordingly, it is possible to obtain a precise interaction of the incident light signal and a specific plasmonic directional mode in a polarization dependent manner.
Assessment of Bacterial diversity in the chicken litter: A potent risk to environmental health
Authors: Kumar Sunil , Yadav Mukesh , Sehrawat Nirmala , Devi Tamanna , Sharma Anil Kumar , Lodhi Moazzam Mohiuddin 
Published: December 2022

Abstract
Raw chicken litters have been applied to field soils where various vegetables are cropped for increasing the yield or productivity. Antibiotics are regularly mixed in the diet or drinking water of chicken grown in the marketable poultry farms for the treating bacterial diseases. Rampant usage of antimicrobials is also resulted in the survival of resistant bacteria in animal excreta, enabling antimicrobial-resistance genes (ARGs) transmission to other microorganisms together with human pathogens. Recently, it has been seen that incorporation of ARGs in vegetables/crops grown in raw manure-amended soil might be due to variations in soil microbial commensals following manure application. An abundances of ARGs like; sul1, aad(A), erm(B), str(A), str(B), intI1 and incW have been traced in manure-mixed soil in many studies compared to unmanured soil leading environmental contamination. Herein, we surveyed multiple investigations to determine how chicken manure affected microbial diversity, the retention of antibiotic-resistant bacteria in soil after manure application, and the transmission of antibiotic resistance genes. Composting can drastically lower enteric bacterial populations, particularly those that carry ARGs. Prior to being applied to the ground, manures can possibly be treated to lessen the danger of polluting crops or water supplies by reducing the prevalence of antibiotic resistance genes. ARGs appear to be a major source of worry in poultry, suggesting that these genes have been widely disseminated in the atmosphere by the industry.
Cytidine deaminase activity predicts clinical outcome of azacitidine in real-world MDS patients
Authors: Donnette Melanie , Hamimed Mourad , Ciccolini Joseph , Sicard Guillaume , Correard Florian , Farnault Laure , Ouafik L'Houcine , Venton Geoffroy , Fanciullino Raphaelle 
Published: December 2022

Abstract
Azacitidine (Vidaza®, Aza) is a mainstay for treating acute myeloid leukemia (AML) in patients unfit for induction chemotherapy and other high risk myelodysplastic syndromes (MDS). Only half of patients usually respond and almost all patients will relapse eventually. There are no predictive factors for response to Aza. Aza is detoxified in the liver by a single enzyme, cytidine deaminase (CDA). CDA is a ubiquitous enzyme coded by a highly polymorphic gene, with subsequent great variability in resulting liver activity. Here we investigated on the link between CDA phenotypic status, toxicity and efficacy of Aza in adult patients treated for AML and MDS. A total of 104 patients were screened in this retrospective, real-world study. Of the 104 patients treated, 67.3% received more than 3 cycles. Treatment was postponed due to Aza-related toxicity in 66% (before Course-2) and 53% (before Course-3) of the patients. Median overall survival (OS) were 15 months (95% CI: 10–22) and 13 months (95% CI: 9–21) in AML and high MDS cohorts, respectively. Responding patients at 3-months showed prolonged survivals, with landmark OS of 17 and 14 months for AML and MDS, respectively. Half of the patients had deficient CDA activity (i.e., < 2 UA/mg), with a lower proportion of deficient patients in MDS patients (34%) as compared with AML patients (67%). In MDS patients, CDA deficiency was correlated with longer landmark OS (14 VS. 8 months; p = 0.03 multivariate analysis), but not in AML patients. In addition, our data suggest that delay in Aza treatment is not associated with lack of efficacy, and thus should not be considered as a signal to shift to other drugs. Overall, our data suggest that CDA is an independent covariate could thus be a marker for predicting clinical outcome in MDS patients treated with Aza.
Nationwide genetic analysis of more than 600 families with inherited eye diseases in Argentina
Authors: Schlottmann Patricio , Pinto José Luna , Labat Natalia , Yadarola Maria Belen , Bainttein Silvina , Esposito Evangelina , Ibañez Agustina , Barbaro Evangelina , Mendiara Alejandro Álvarez , Picotti Carolina , Misisian Andrea Chirino , Andreussi Luciana , Gras Julieta , Capalbo Luciana , Visotto Mauro , Dipierri José , Alcoba Emilio , Gabrielli Laura Fernández , Ávila Silvia , Aucar Maria Emilia , Martin Daniel , Ormaechea Gerardo , Inga M. , Francone Anibal , Charles Martin , Zompa Tamara , Pérez Pablo , Lotersztein Vanesa , Nuova Pedro , Canonero Ivana , Michaelides Michel , Arno Gavin , Varela Malena Daich 
Published: December 2022

Abstract
Background: To conduct the first large-scale genetic analysis of inherited eye diseases (IED) in Argentina and describe the comprehensive genetic profile of a large cohort of patients.
Methods: This is a retrospective study analyzing medical records of 22 ophthalmology and genetics services throughout 13 Argentinian provinces. Patients with a clinical diagnosis of an ophthalmic genetic disease and a history of genetic testing were included. Medical, ophthalmological and family history was collected.
Results: 773 patients from 637 families were included, with 98% having inherited retinal disease. The most common phenotype was retinitis pigmentosa (RP, 62%). Causative variants were detected in 377 (59%) patients. USH2A, RPGR, and ABCA4 were the most common disease-associated genes. USH2Awas the most frequent gene to cause RP, RDH12 early onset severe retinal dystrophy, ABCA4 Stargardt disease, PROM1 cone-rod dystrophy, and BEST1 macular dystrophy. The most frequent variants were RPGRc.1345C>T, p.(Arg449*) and USH2A c.15089C>A, p.(Ser5030*). The study revealed 159/448 (35%) previously unreported pathogenic/likely pathogenic variants and 5 likely founder mutations.
Conclusions: We present the genetic landscape of IED in Argentina and the largest cohort in South America. This data will serve as a reference for future genetic studies, aid diagnosis, inform counselling, and assist in addressing the largely unmet need for clinical trials to be conducted in the region.
Dynamic Evaluation on Slope Ecological Restoration Effect Based on CS and MC
Authors: Chen Wenqiang , Sun Yongai 
Published: December 2022

Abstract
It is important to evaluate the slope ecological restoration effect for diagnosing the slope restoration state in time. Several soft computing methods require experts to determine the index weight, which will affect the rationality of the evaluation results. Moreover, they are all static evaluation methods and cannot reflect the time effect of restoration. Therefore, a dynamic evaluation method has been proposed without determining the index weight based on Cosine Similarity and Markov Chain. Several cases were applied to prove the effectiveness of the proposed method. The results presented that the results of this method are more consistent with the actual situations and can reflect the variability of the restoration effect. Finally, the sensitivity of indexes under different ecological restoration methods was analyzed. The results show that the core link of the restoration method was consistent with the sensitivity result. The proposed method provides a basis for optimizing the restoration methods.
Audio-Text Retrieval Based on Contrastive Learning and Collaborative Attention Mechanism
Authors: Hu Tao , Xiang Xuyu , Qin Jiaohua , Tan Yun 
Published: December 2022

Abstract
Existing research on audio-text retrieval is limited by the size of the dataset and the structure of the network, making it difficult to learn the ideal featuresof audio and text resulting in low retrieval accuracy. In this paper, we construct an audio-text retrieval model based on contrastive learning and collaborative attention mechanism . We first reduce model overfitting by implementing audio augmentation strategies including adding Gaussian noise, adjusting the pitch and changing the time shift.Additionally, we design a co-attentive mechanism module that the audio data and text data guide each other in feature learning, effectively capturing the connection between the audio modality and the text modality. Finally we apply the contrastive learning methods between the augmented audio data and the original audio, allowing the model to effectively learn a richer set of audio features. The retrieval accuracy of our proposed model is significantly improved on publicly available datasets AudioCaps and Clotho.
Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory-entorhinal-amygdaloid axis in Alzheimer´s and Parkinson´s diseases
Authors: Cartas-Cejudo Paz , Lachén-Montes Mercedes , Ferrer Isidro , Fernández-Irigoyen Joaquín , Santamaría Enrique 
Published: December 2022

Abstract
Background: Smell impairment is one of the earliest features in Alzheimer’s (AD) and Parkinson’s diseases (PD). Due to sex differences exist in terms of smell and olfactory structures as well as in the prevalence and manifestation of both neurological syndromes, we have applied olfactory proteomics to favor the discovery of novel sex-biased physio-pathological mechanisms and potential therapeutic targets associated to olfactory dysfunction.
Methods: SWATH-MS (sequential window acquisition of all theoretical fragment ion spectra mass spectrometry) and bioinformatic workflows were applied in 57 postmortem olfactory tracts (OT) derived from non-demented (n=6F/11M), AD (n=4F/13M) and PD (n=7F/16M) subjects. Complementary molecular analyses by Western-blotting were performed in the olfactory bulb (OB), entorhinal cortex (EC) and amygdala areas.
Results: 327 and 151 OT differentially expressed proteins (DEPs) were observed in AD women and AD men respectively (35 DEPs in common). Respect to PD, 198 DEPs were identified in PD women whereas 95 DEPs were detected in PD men (20 DEPs in common). This proteome dyshomeostasis induced a disruption in OT protein interaction networks and widespread sex-dependent pathway perturbations in a disease-specific manner, among them Sirtuin (SIRT) signaling. SIRT1, SIRT2, SIRT3 and SIRT5 protein levels unveiled a tangled expression profile across the olfactory-entorhinal-amygdaloid axis, evidencing disease- sex- and brain structure-dependent changes in olfactory protein acetylation.
Conclusions: Alteration in the OT proteostasis was more severe in AD than in PD. Moreover, protein expression changes were more abundant in women than men independent of the neurological syndrome. Mechanistically, the tangled SIRT profile observed across the olfactory pathway-associated brain regions in AD and PD indicates differential NAD (+)-dependent deacetylase mechanisms between women and men. All these data shed new light on differential olfactory mechanisms across AD and PD, pointing out that the evaluation of the feasibility of emerging sirtuin-based therapies against neurodegenerative diseases should be considered with caution, including further sex dimension analyses in vivo and in clinical studies.
A DFT study of the hydrogen storage potentials and properties on Ca, Fe, and Ti deposited NaSi 20 fullerenes
Authors: Yang Huixi , Liu Bin , ren Hongjiang 
Published: December 2022

Abstract
In this work, the hydrogen storage materials of Ca, Fe, and Ti deposited NaSi20 clusters have been investigated utilizing DFT methods (B3LYP and M06-2X) at the 6-311G(d, p) level. The orbital analysis and thermodynamic analysis were carried out and the adsorption capacity of H2 molecules by hydrogen storage materials are predicted. The results show that the encapsulated Na atoms in the Si20 cluster provide a relatively regular shape for the NaSi20 fullerene cluster. And Ca, Fe, and Ti atoms tend to bind with two adjacent Si atoms of NaSi20 cluster. The Ca@NaSi20, Fe@NaSi20, and Ti@NaSi20 can adsorb up to three, four, and six hydrogen molecules, respectively. The adsorption energy (Eads) per hydrogen molecule meets the United States Department of Energy (DOE) target for hydrogen storage materials for nH2-Ti@NaSi20 (n = 2–6) and nH2-Fe@NaSi20 (n = 1–4), implying that Fe and Ti deposited NaSi20 fullerene may be a potentially suitable material for hydrogen storage.
Macroscopic and histopathological investigation of Sarcocystis infection in sheep
Authors: bahrami ali mohammad , rajabi sepideh 
Published: December 2022

Abstract
Sarcocystis infection is one of the most common single-cell infections between humans and livestock.
Considering the health importance of this parasite, in the present study, the level of infection with macroscopic and microscopic sarcocystis cysts in slaughtered sheep was investigated.
work method:In this study, samples were taken from the esophagus, diaphragm, heart and intercostal muscles, and in order to find macroscopic and microscopic cysts, the samples were examined by two methods of direct observation (macroscopic and) histopathology. The basis of diagnosis of microscopic cysts is preparation of slides from samples and hema toxylin eosin staining, then microscopic observation of parasite zoites.
Statistical analysis was done with Spss software and a significance level of 0.05 was considered.
Results:In the examination of the samples related to each of the sheep carcasses, 34.82% macroscopically and 81.09% histopathologically were diagnosed positive for the presence of sarcocystis cysts. Also, a significant statistical difference was observed between the amount of contamination in different muscles (p ≤ 0.05). In the macroscopic examination, the most cases of sarcocystis infection were in the diaphragm and in the microscopic method, it was related to the heart. Contamination was observed in males more than females. Sarcocystis infection has been more in children under one year old.
Conclusion It is suggested to carefully examine the carcasses and local or total removal of the carcasses in the slaughterhouse, and also to refrain from consuming grilled and semi-cooked sheep meat.
Surgical resection for non-small cell lung cancer invading the chest wall: A 12-year experience in a single center
Authors: Batıhan Güntuğ , Üçvet Ahmet , Yazgan Serkan , Ceylan Kenan Can , Gürsoy Soner , Kaya Seyda Ors 
Published: December 2022

Abstract
Background
Patients with chest wall invasion, which constitute 5-10% of operable non-small cell lung cancer cases, are heterogeneous in terms of factors that may affect the prognosis. We aim to share our experience including the surgical results of patients with non-small cell lung cancer (NSCLC) who underwent chest wall resection and identify the potential factors that may impact the survival.
Methods
The patients who underwent combined chest wall and lung resection due to primary lung cancer invading the chest wall in our center between 2007 and 2019 were reviewed. Variables such as age, tumor size, histological subtype, surgical technique, depth of invasion, the extent of resection, histological subtype, neoadjuvant, and adjuvant treatment status were examined.
Results
254 patients who underwent combined chest wall and lung resection were included in the study. There were 245 men and 9 women. The mean age was 61.0 ± 8.4 years. The overall survival was 70.9 ± 4.6 months, and the 5-year survival rate was 41.5 ± 3.3%. In multivariate analyses, age, the extent of lung resection, the number of resected ribs, invasion depth, and completeness of chest wall resection were independent factors that have an effect on survival.
Conclusions
This study shows that age, the extent of lung and chest wall resection, invasion depth, and completeness of chest wall resection are independent prognostic factors of survival in patients who underwent combined lung and chest wall resection for NSCLC.
Trial registration
Institutional Review Board of the Dr Suat Seren Chest Diseases and Surgery Medical Practice and Research Center (No: E-49109414-604.02.02)
Network-on-chip router input port architectures
Authors: fard elnaz shafigh , jamali mohammad ali jabrael , masdari mohammad , majidzadeh kambiz 
Published: December 2022

Abstract
With the increase in the number of processing cores on a chip, a highly efficient and scalable structure such as a network on a chip was proposed. Network-on-chip is a technology presented to solve the limitations of system-on-chip that includes a set of multiprocessors. In network-on-chip systems, delay in communication and reaching the ideal speed is one of the concerns of academic and industrial researchers today. Although network-on-chip offers a favorable solution to reduce the problem of the long delay of wires compared to traditional structures, communication delay is still a challenge. In this article, the various types of network router input ports architecture on the chip are reviewed and the operational comparison and evaluation of the technologies proposed in this field are mentioned.
Prediction of even and odd sunspot cycles
Authors: Asikainen Timo , Mantere Jani 
Published: December 2022

Abstract
Here we study the prediction of even and odd numbered sunspot cycles separately, thereby taking into account the Hale cyclicity of solar magnetism. We first show that the temporal evolution and shape of all sunspot cycles are extremely well described by a simple parameterized mathematical expression. We find that the parameters describing even sunspot cycles can be predicted quite accurately using the sunspot number 41 months prior to sunspot minimum as a precursor. We find that the parameters of the odd cycles can be best predicted with geomagnetic maximum geomagnetic aa index close to fall equinox within a 3-year window preceding the sunspot minimum. We use the found precursors to hindcast all previous sunspot cycles and evaluate the performance with a cross-validation methodology, which indicates that each past cycle is very accurately predicted. For the coming sunspot cycle 25 we predict an amplitude of 171 ± 23 and the end of the cycle in September 2029 ± 1.9 years. We are also able to make a rough prediction for cycle 26 based on the predicted cycle 25. While the uncertainty for the cycle amplitude is large we estimate that the cycle 26 will most likely be stronger than cycle 25. These results suggest an increasing trend in solar activity for the next decades.
Estimating urban seismic damages and debris at the building-level: Application to the city of Beirut, Lebanon
Authors: Iskandar Rouba , Tfaily Bilal Al , Cornou Cécile , Bard Pierre-Yves , Guillier Bertrand , Harb Jacques , Lacroix Pascal , Adjizian-Gérard Jocelyne , Beck Elise , Dugdale Julie , Salameh Christelle , Saliba Nada , Zaarour Rita 
Published: December 2022

Abstract
The estimation of seismic damages and debris at the urban scale - at a precise building-by-building level- is challenging for several reasons. First, commonly used methodologies for seismic damage estimation rarely take into account the local site effects, precisely at the building-level. Second, the available methods for debris estimation fail to estimate at the same time the quantity of debris generated per building according to its damage level and the distribution of the debris (extent and height) around buildings. Finally, the lack of comprehensive data on the building stock and the relevant building properties and their taxonomy further increases the complexity of assessing possible earthquake consequences at an urban scale. This paper addresses these challenges and proposes improvements to the assessment of seismic damages and debris at the building level, along with the development of a 3D building model based on satellite images and heterogeneous data. These developments, applied to the city of Beirut, Lebanon, highlight the control of the site effects on the seismic damage spatial distribution throughout the city and the large volume and extent of debris to be expected in the city for a strong earthquake.
Damage as a Material Phase Transition
Authors: Puglisi Giuseppe , Giuseppe Saccomandi , De Tommasi Domenico , Andrea Bucchi 
Published: December 2022

Abstract
We propose paradigmatic examples to show how material damage effects can be described as a solid-solid phase transition. Start- ing from the pioneering work of J.L. Ericksen [8] and the extensions of R.L. Fosdick to three-dimensional non linear elasticity, we describe the insurgence of damage as a transition between two material states (dam- age and undamaged) characterized by two different energy wells. We consider the two separate constitutive assumptions of a simple damage- able Neo-Hookean material and a more complex microstructure inspired Gent material with variable limit threshold of the first invariant. In both cases we study two different deformation shear classes, one homogeneous and the other one inhomogeneous and obtain fully analytic description of the system damage response under cyclic loading. While the assumption of two only (damaged and undamaged) configurations is simplistic, the model can be extended to systems with more energy wells with varaible degrees of damage.
Decolorization of Stevia rebaudiana (Bert.) leaf extracts with activated charcoal and qualitative analysis of stevioside using chromatographic methods
Authors: Bhuiyan Mohammad , Shamima Kazi Asma Ahmed , Nahid Meher , Afrin Sadia , Hoque Mohammad Amirul , Haque Mohammad Majedul , Sarker Md. Khabir Uddin , Miah Md. Abdus Satter , Shaikh Md. Aftab Ali 
Published: December 2022

Abstract
The Stevia rebaudiana (Bert.) leaves are natural low-calorie sweeteners that are used in a wide range of products, including foods, drinks, medicines, cosmetics, and more. The current study aims to obtain high purity stevioside by first decolorizing the Stevia leaf extracts with activated charcoal, then purifying them with 70% ethanol and concentrating them in a rotary evaporator, respectively. The yield was then calculated by weighing the crystallized sample following freeze-drying. The average yield is 8.13%. According to High-Performance Liquid Chromatography (HPLC), the purity is 98.12%. The obtained stevioside was compared to standard stevioside and confirmed using UV-Visible and Fourier Transform Infrared (FT-IR) spectroscopy. The purified sample showed a wave number region of 4000–650 cm-1 in FT-IR and in the UV-Vis spectrum, a peak was found at a wavelength of 206.49 nm. An accuracy and precision test was done with a crystal sample, which gave a similar spectrum to the standard stevioside at the same retention time in HPLC. The pH effect on the decolorization of Stevia leaf extracts with activated charcoal was 5.5–8.0. In contrast to other commercially available methods, the aforementioned method can be used to produce pure stevioside from Stevia leaf extracts rapidly, simply, and, inexpensively.