bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic performance evaluation of concrete gravity dams using an efficient finite element model
Authors: RASA Ahmad Yamin , Budak Ahmet , Düzgün Oğuz Akın 
Published: December 2022

Abstract
The effective numerical model that examines the seismic behavior of concrete gravity dams in the Laplace domain-Finite Element (FE) approach is presented. Further research on the potential damage levels and seismic performance of the dam body is done considering the simultaneous effect of horizontal (H) and vertical (V) components of six different earthquake loads. The time durations of the selected earthquakes vary from 10 sec to 80 sec with the magnitude range from 6.5 to 7.62 Mw. The Lagrangian fluid finite elements are utilized to model the near-field water domain. On the other hand, the fluid infinite elements are utilized to model the far-field water domain considering the rigid base rock foundation condition. The two-dimensional (2D) model is developed in FORTRAN 90 and MATLAB programming languages. The findings of this study suggest that the seismic behavior of concrete gravity dam affects not only with the seismic severity; the length and significant time duration of the earthquake are also important factor. The evaluation of the obtained results revealed that the longer length of significant earthquake duration leads to the high deformations, the high stress excursions and high probability of damages in the dam. 20.9% and 18.8% of the selected dam cross section experiences overstress condition under the H and H + V components of the Chi-Chi earthquake loads, respectively; which result the dam failure.
A Sensitive and Robust DNA Method for Authenticity Determination of Glehnia littoralis and Its Food Products
Authors: Lin Mengchen , Wang Hongtao , Yu Qiaoning , Wang Dandan 
Published: December 2022

Abstract
Glehnia littoralis has been widely recognized for its comprehensive nutritional properties and pharmaceutical effects. However, the adulteration practices with cheaper or very similar species in its food products lead to unfair market competition and severe health risks to the consumers. In this study, two species-specific PCR systems were constructed for molecular discrimination of G. littoralis from its adulterants based on the single nucleotide (SNP) markers exploited from ribosomal ITS and chloroplast trnL-F regions, respectively. The species-specific PCR assay utilizing trnL-F region was able to detect 0.1% of intentional adulteration of genomic DNA with a detection limit of 0.01 ng. The developed method, mitigating the adverse effects of DNA degradation and false negative results, was proved to be effective for botanical origin authentication of G. littoralis food products in a single reaction. Therefore the present study provides a sensitive and robust DNA method for authenticity determination of G. littoralis and its food products, and the established method can be employed to determine the authenticity and adulteration of other agro-products with high accuracy and reliability.
Hash the Universe: Differentially Private Text Extraction with Feature Hashing
Authors: Fletcher Sam , Roegiest Adam , Hudek Alexander K. 
Published: December 2022

Abstract
Using artificial intelligence for text extraction can often require handling privacy-sensitive text. To avoid revealing confidential information, data owners and practitioners can use differential privacy, a definition of privacy with provable guarantees. In this work, we show how differential privacy can be applied to feature hashing.Feature hashing is a common technique for handling out-of-dictionary vocabulary, and for creating a lookup table to find feature weights in constant time. One of the special qualities of feature hashing is that all possible features are mapped to a discrete, finite output space. Our proposed technique takes advantage of this fact, and makes hashed feature sets Renyi-differentially private.
The technique enables data owners to privatize any model that stores the data-dependent weights in a hash table, and provides protection against inference attacks on the model output, as well as against linkage attacks directly on the model's hashed features and weights. As a case study, we show how we have implemented our technique in commercial software that enables users to train text sequence classifiers on their own documents, and share the classifiers with other users without leaking training data.
Results show that even common words can be protected with (0.06, 10^-5)-differential privacy, with only a 1% average reduction in Recall and no change in Precision.
The balance between lung regulatory T cells and Th17 cells is a risk indicator for the acute exacerbation of interstitial lung disease after surgery
Authors: Fukui Mariko , Harada Norihiro , Takamochi Kazuya , Hayashi Takuo , Matsunaga Takeshi , Hattori Aritoshi , Kawagoe Izumi , Suzuki Kenji 
Published: December 2022

Abstract
Purpose: Acute exacerbation of interstitial lung disease is the leading cause of 30-day mortality among patients with lung cancer in Japan. We assessed the characteristics of the lung immune environment before the onset of acute exacerbation of interstitial lung disease.
Methods: This retrospective matched case-control study comparing the immune phenotype of helper T cells in the lung from patients with and without acute exacerbation of interstitial lung disease after surgery was conducted in 135 patients who underwent surgical resection for lung cancer and were pathologically diagnosed with interstitial lung disease at our institute between 2009 and 2018. There were 13 cases of acute exacerbation of interstitial lung disease and 122 cases without acute exacerbation matched using propensity score analysis, and 12 cases in each group were compared. We evaluated the percentage of T helper (Th)1, Th2, Th17, regulatory T cells (Treg), and CD8 cells in CD3+ T cells and the Th1:Th2, Th17:Treg and CD8:Treg ratios in patients with acute exacerbation by immunostaining of lung tissue in the non-tumor area.
Results: We found a significant difference in the lung Th17:Treg ratio between patients with and without acute exacerbation (1.47 and 0.79, respectively; p=0.041). However, we detected no significant differences in the percentages of lung Th1 (21.3% and 29.0%), Th2 (34.2% and 42.7%), Th17 (22.3% and 21.6%), Treg (19.6% and 29.1%), or CD8+ T cells (47.2% and 42.2%) of CD3+ T cells between groups.
Conclusion: Th17:Treg ratios in the lung from patients with acute exacerbation were higher than in those without.
Smart Grids Reliability Assessment Using a Simplified Mapping Step
Authors: Gholami Mohammadreza , Mohammadtaheri Meysam , Gholami Alireza 
Published: December 2022

Abstract
Reliability of the smart grids has always been an important factor considered by power system planners. Cyber network failures have significant impacts on the reliability of the smart grids as a cyber-physical system. The complexity of the reliability assessment of cyber-physical systems is significantly higher than traditional power systems due to interdependency between cyber and power network elements. A mapping step is applied to system states to address this interdependency in the reliability assessment task. This paper aims to lower the complexity and computational cost of reliability assessment in cyber-physical systems by proposing a simplified mapping step. The simplification steps are applied to various connection types between cyber components using a defined interconnection matrix based on the cyber network topology. The two-state reliability model probabilities are updated for each cyber element. The proposed method lowers the number of possible system states and computational cost significantly since the effects of some cyber networks are considered in the probability updating step. The proposed approach is applied to different cyber network topologies such as bus, ring, and redundant star in a microgrid. Loss of load probability and expected energy not supplied are calculated as the reliability indices of the system. The results reveal the efficiency of proposed method in reliability assessment of the cyber-physical system using remarkably decreased numbers of system states.
Study on Mechanical Properties of Single Fractured Dry Heat Rock Under Uniaxial Compression
Authors: Zhu Dong , Fan Yuqing , Jing Hongwen , Yue Liang , Jin Huiwu , Miao Lei gang 
Published: December 2022

Abstract
Uniaxial compression tests were carried out on single fissure slab granite specimens (size 80 mm×160 mm×30 mm) at 250,350 and 450°C after several (1-20) hot and cold treatments using a rock mechanics servo tester MTS816, acoustic emission meter and high speed digital photography to analyze the effects of temperature and number of treatments on the strength-deformation characteristics and crack evolution of single fissure granite. It was found that the peak strength of the specimens at the three heating temperatures showed a continuous decrease with the increase of the number of treatments, among which, the decrease of the peak strength of the specimens at 250 ℃ was the smallest, the decrease at 450 ℃ was the middle, and the decrease at 350 ℃ was the largest. Based on the analysis of the acoustic emission characteristics during the loading of single fissure slab granite, for each larger acoustic emission event generated, the cumulative acoustic emission appears to increase steeply, and the corresponding rupture of the specimen takes the form of the production of a new crack, crack extension or sheet crack initiation. The crack evolution characteristics of different single-fissure slab granite specimens were analyzed by photogrammetric techniques. Finally, the effects of temperature and number of treatments on the cracking and damage of single fissure slab granite were investigated. The cracking stress and yield strength tended to decrease nonlinearly with increasing temperature, with the greatest decrease after 5 treatments at 250 and 350°C, however, the greatest decrease was reached after 15 treatments at 450°C and the form of damage to the specimen by the prefabricated fracture is influenced both by the temperature and the number of treatments.
An influence of Nano particles of bentonite clay on mechanical properties of ferrous clay composite through additive manufacturing route
Authors: Bhosale Shrikrushna B. , Bhowmik Sumit , Ray Amitava 
Published: December 2022

Abstract
The powder metallurgy (P/M) components have been extensively used in industrial applications and P/M components properties has been influenced by alloying elements and porosity. In the present work, the bentonite clay (aluminum silicate) as porosity filler has been mixed in the ferrous alloy for manufacturing of low porosity P/M components. The specimens have been manufactured by using iron-carbon-copper and iron-carbon-copper-nickel- molybdenum with bentonite clay. The bentonite clay has varied with wt. % of 1–5% at the interval of 1%. To recognize the effect of bentonite clay, the mechanical properties such as density and porosity have measured and the crushing strength, and hardness test has carried out. Also, microstructure analysis has been carried out by optical microstructure study and scanning electron microscopy (SEM). Further the X-ray diffraction (XRD) and Energy Dispersive Spectrometry (EDS) analysis has been carried out for clay particles location and homogeneous mixing. The micro-structure and chemical composition analysis shows that the clay remains at grain boundary. The test results shows that the porosity has significantly reduced while, slightly reduction has been found in density, hardness and crushing strength with an increase in wt. % of clay. This analysis show that the 1% of Nano-particles of bentonite clay is helpful as porosity fillers with acceptable mechanical properties.
Colorectal cancer with germline BRCA1 variant: A case report
Authors: Kim Kyoung Min , Lee Min Ro , Ahn Ae Ri , Chung Myoung Ja 
Published: December 2022

Abstract
Background: Sporadic colorectal cancer (CRC) is the most common form of CRC. However, hereditary CRC is also common. BRCA 1/2 (Breast Cancer Gene, 1 and 2) variants increase the risk for breast and ovarian cancers. CRC has also been associated with BRCA variants, but the relevant risks are not clear. We present a case of rectal cancer with a germline BRCA1 pathogenic variant.
Case Report: A 39-year-old male was admitted to our hospital with rectal carcinoma that had been detected in a local hospital. The patient underwent surgical resection and pathologic diagnosis was adenocarcinoma. Next generation sequencing (NGS) was performed and the BRCA1 variant was detected. Reviewing the public database and considering the young age of the patient, the variant was suggested to be germline. Thereafter, to confirm the variant to be germline, normal tissue was sequenced and the same BRCA1 variation was detected. Moreover, the patient’s father had prostatic cancer and NGS testing revealed the identical BRCA1 variant.
Conclusions: In the BRCA cancer group, there is relatively little attention paid to male cancer compared to female cancer. The accumulation of male BRCA-related CRC reports may contribute to establishing a relationship between the two.
High-resolution anorectal manometry in the diagnosis of moderate rectocele in symptomatic women compared to healthy subjects
Authors: Geng Hong Zhi , Zhang Yi , Xu Chen , Cong Jiying , Li Yuwei 
Published: December 2022

AbstractBackgroundFew studies have investigated the healthy subject in women (HSW) and moderate rectocele in the symptomatic women (MRSW) identifiedby using three-dimensional high-resolution anorectal manometry(3D HARM) parameters correlate age stratification.ObjectiveClinical diagnostic values were explored between the MRSW and the HSW groups by 3D HARM parameters related to age stratification.MethodsA retrospective cohort study involving 128 cases from the MRSW and HSW groups by using 3D HARM parameters was enrolled at Tianjin Union Medical Center between January 2017 and June 2022.ResultsLinear regression analysis showed that age was an independent risk factor for the prognosis of maximum squeezing pressure in females (P= 0.000). In the HSW group, age was negatively correlated with maximum resting pressure and maximum squeeze pressure in females, (P= 0.029), and (P= 0.001), respectively.Logistic regression analysis showed that age and RAIR were independent factors in the prognosis of MRSW, (P= 0.024), and (P= 0.001), respectively.ConclusionAge and RAIR were independent risk factors for prognosis in the MRSW group compared to the HSW group using 3D HARM, and age was also an independent risk factor for the prognosis of maximum squeezing pressure in women.
Weaning caused imbalanced T lymphocytes distribution and impaired intestinal immune barrier function in piglets
Authors: YU li huai , Dong li , Wang Meng xuan , Peng Zhong , Wang Hongrong , li Hongmin , Qin Tao , Yin Yinyan 
Published: December 2022

Abstract
A total of 40 piglets with similar body weights were selected in pairs at 21 days old and divided into the suckling group (SG: breastfed by their mothers) and weaning group (WG: weaned at 21 days old). Eight piglets from each group were randomly selected and sacrificed at 24 days (SG3 and WG3) and 28 days of age (SG7 and WG7). The growth performance, T lymphocyte subpopulations, the concentration of cytokines and immunoglobulins, and the expression of Notch2 signaling proteins were determined. The weaning caused a decrease in body weight (P < 0.01) and the ratio of CD3+CD4+/CD3+CD8+ T cells in thymus (P < 0.05). Compared to SG3, the concentration of secretory immunoglobulin A (sIgA) in jejunum was decreased, and that of interleukin 2 (IL-2) in serum and ileum, IL-1β and IL-2 in jejunum were upregulated (P < 0.01), while IL-10 in the small intestine was downregulated (P < 0.05) in WG3. Weaning downregulated gene expression of IL-4 and upregulated gene expression of IL-1β, IL-12, and interferon γ (IFN-γ) in small intestine (P < 0.05). Further, weaning downregulated protein expression of Notch2 and Hes1 but upregulated Jagged1 expression in small intestine of piglets (P < 0.05). In summary, weaning caused an imbalance in T lymphocytes distribution, thus impairing the intestinal immune function of piglets, which might be associated with the Notch2 signaling. Furthermore, the impairment of intestinal immune barrier function was more severe at 3 days post-weaning than that at the 7 days post-weaning in piglets.
A nonlinear system dynamics and simulation analysis of fractional order modelling on employees negative attitude towards their workplace with intervention strategies
Authors: Teklu Shewafera Wondimagegnhu , Mamo Dejen Ketema 
Published: December 2022

Abstract
In this paper, we have formulated and analyzed a Caputo fractional order mathematical model with intervention strategies on employees’ negative attitudes towards the workplace. Non-negativity and boundedness of the dynamical system solutions have been analyzed. The existence and stability of negative attitude-free and negative attitude endemic equilibrium points of the Caputo fractional order model were investigated and analyzed. The negative attitude-free equilibrium is local stability. The backward bifurcation of the Caputo fractional order model was conditionally analyzed whenever the effective reproduction number could be less than one. Further, we performed our analytical results through numerical simulations and obtained consistent results. Efficient employee protection and treatment of negative attitudes toward the workplace reduce and potentially removes negative attitudes from the employees.
Exome-wide association study identified genetic variants contributing to the risk of cerebral palsy
Authors: Xing Qinghe , Cheng Ye , Xu Yiran , Li Hongwei , Qiao Yimeng , Wang Yangong , Su Yu , Zhang Jin , Wang Xiaoyang , Zhu Changlian 
Published: December 2022

Abstract
Cerebral palsy (CP) is the most common physical disability in childhood that results from the interaction of environmental and genetic factors. Yet in many patients, the etiology remains unknown. We identified significant association at rs3131787 within the human leukocyte antigen (HLA) region using two-stage association study between 1,090 CP cases and 1,100 controls. Fine mapping of the HLA region indicated that the carrier frequency of HLA-B*13:02 was significantly higher in CP, particularly in CP without preterm birth, low birth weight, birth asphyxia or periventricular leukomalacia (PVL). DRB1*07:01/DQA1*02:01 was also significantly enriched in CP and more specifically in dyskinetic type. Additionally, significant enrichment of carrier frequency was detected for HLA-A*32:01 in CP with either preterm birth or low birth weight and for HLA-B*27:05 in CP with birth asphyxia. These data suggest that immune dysregulation resulting from immunogenetic variants or environmental exposures may underlie the pathogenesis of CP.
Protective anti-inflammatory effects of photobiomodulation with Red/NIR light in a mouse model of LPS-induced systemic and brain inflammation
Authors: Shamloo Shirin , Defensor Erwin , Ciari Peter , Ogawa Gaku , Vidano Laura , Lin Jennifer S. , Fortkort John A. , Shamloo Mehrdad , Barron Annelise E. 
Published: December 2022

Abstract
Background
There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is a safe approach shown to have anti-inflammatory effects. The current study was aimed at evaluating the effects of PBM on LPS-induced peripheral and central inflammation in mice to assess the potential of PBM as an anti-inflammatory treatment.
Methods
Effects of PBM were evaluated in group-housed C57BL/6J mice. Mice were divided into three groups: (a) a control group receiving no PBM, (b) a group receiving PBM utilizing red/NIR light at 640 and 880 nm (RL), and (c) a group receiving RL with a 40 Hz gamma frequency flicker (RLG). PBM was administered over 12 days (5 days per week for 2 weeks; no treatment on days 6 and 7). Each PBM treatment was 30 minutes. On day 11, mice were dosed by intraperitoneal injection with either vehicle or LPS (1 mg/kg). Brain and plasma samples were collected on day 12, 24 hours after LPS/vehicle injection and after one final PBM treatment. Samples were investigated for inflammatory responses, using qPCR to measure mRNA expression and western blot and Luminex assays to measure protein expression levels.
Results
Analysis by qPCR revealed that PBM with RL and RLG significantly reduced the gene expression of IL-18, while RL also reduced IL-6 expression in the brain. Luminex analyses confirmed that LPS induced the expected robust upregulation of cytokines in plasma and the brain. In plasma, RL and RLG modulated LPS induction of IL-10, IL-1β, IL-22, and IL-7Rα. In addition, RL modulated LPS-induction of IL-18 and MIP-1β, while RLG modulated IP-10, IFN-γ, RANTES, MCP-1, IL-2Rα, and BTC. In hippocampal-containing brain tissue, RL and RLG prevented the LPS-induction of ST2 and IFN-α, while RLG also inhibited the LPS-induction of sRANKL, MCP-1, and IL-15.
Conclusions
Daily, 30-minute PBM treatment with RL or RLG for 10 days prior to an LPS challenge had anti-inflammatory effects in C57BL/6J mice, in the brain and systemically. RL, independent of gamma flicker, provided robust anti-inflammatory effects, and the addition of gamma flicker further potentiated these effects. Overall, these results show the potential of PBM as an experimental anti-inflammatory treatment. Future studies will be needed to understand the mechanism of action, safety, and effectiveness of PBM.
Effects of Coffee Supplementation on Homocysteine and Leptin Levels: A Systematic Review and Meta-analysis of Clinical Trials
Authors: Simental-Mendía Luis E. , Simental-Mendía Mario , Ríos-Mier Mayela 
Published: December 2022

Background:
It has been reported that the consumption of antioxidant foods and beverages may benefit
the development of cardiovascular risk factors. However, the impact of coffee consumption on some of these
factors, such as homocysteine and leptin is controversial. Some clinical trials have suggested that coffee administration
increases plasma total homocysteine levels, while others have found no significant changes in
leptin concentrations.

Objective:
This study aimed to assess the effects of coffee supplementation on homocysteine and leptin concentrations
in a meta-analysis of clinical trials.

Method:
PubMed, Web of Science, Scopus, ClinicalTrials.gov, and Google Scholar databases were searched
from inception to September 29, 2021. A fixed-effects model and the generic inverse variance weighting
method were used for meta-analysis.

Results:
The meta-analysis demonstrated that coffee administration significantly increases homocysteine levels
(WMD: 0.55 μmol/L, 95% CI: 0.17, 0.93, p = 0.005, I2 = 0%) but has no significant changes in leptin concentrations
(WMD: 1.34 ng/mL, 95% CI: -0.78, 3.45, p = 0.21, I2 = 0%). Additionally, the sensitivity analysis was robust
for both homocysteine and leptin levels.

Conclusion:
The results of the present meta-analysis revealed that coffee supplementation raises serum homocysteine
concentrations but has no effect on circulating leptin levels.