bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTATION AND TOURIST PERCEPTION OF SAPTA PESONA AT TAMAN KUPU-KUPU, SUKAJADI TOURISM VILLAGE, BOGOR
Authors: Ishak Riani P. 
Published: March 2022

This study aims to determine, describe, and analyze (1) the implementation of Sapta Pesona at Taman Kupu-Kupu in the Sukajadi Tourism Village and (2) the tourists' perception of Sapta Pesona actualization at Taman Kupu-Kupu in the Sukajadi Tourism Village. The research method used in this research is descriptive research with a mixed approach. Data collection techniques used are observation, interviews, questionnaires, and documentation and literacy. The analysis method used is (1) Miles and Huberman qualitative data analysis in the form of data reduction, data presentation, and drawing conclusions. Then the second is quantitative data analysis with descriptive statistical analysis using SPSS. The sample in this study were tourists who visited the Taman Kupu-Kupu in Sukajadi Tourism Village in May 2021, which is limited due to pandemic Covid-19. The results of this study indicate that (1) the application of Sapta Pesona Taman Kupu-Kupu Sukajadi Tourism Village on the seven elements has generally been carried out well, however, each indicator still can be improved to the most optimal level, in particular for elements safe, clean, cool, and beautiful. Furthermore, a survey on tourist perceptions in regard to the implementation of Sapta Pesona at Taman Kupu-Kupu Sukajadi Tourism Village is rated excellent on these elements: orderliness, friendliness, and memorable. Various efforts can still be worked on to reach maximum value for Sapta Pesona implementation. By improving its organizational strategy, providing skills training for its employee, preparing written and displayed Standard Operating Procedure in the park, building cooperation with related parties and improving marketing and promotion strategy are some recommendations can be conducted by the management of Taman Kupu-Kupu Sukajadi Tourism. Based on the results of this study. Moreover, it is strongly recommended that the Bogor Regency Tourism and Culture Office should pay more attention to conducting regular supervision of developing tourism villages in Bogor so that the implementation of Sapta Pesona can be optimized.
Keywords: Sapta Pesona, Tourist Perception, Tourism Village , Sukajadi Village
ANALYSIS OF MARKETING ASPECT IN FEASIBILITY STUDY OF ASIAN CULTURE GALLERY IN WEST JAKARTA
Authors: Sitorus Nova , Juliana Juliana , Kho Chaterine 
Published: March 2022

Based on the data and explanation above, the writer decided to make a business feasibility study from the marketing aspect of an art gallery. The art gallery that will be discussed in this business feasibility study is entitled Asian Culture Gallery. The Asian Culture Gallery, located in West Jakarta, is an art gallery that displays various paintings and explanations of traditional culture, such as traditional dances, special foods, official languages ​​and also traditional clothing from various countries in Asia. These countries include South Korea, Japan, Indonesia, India and the Middle East. In order to produce supporting data, reliable data sets and sources are needed. Therefore, the data obtained must be valid and reliable data. The business feasibility study of the Asian Culture Gallery located in West Jakarta collects data using scientific methods, namely primary data and secondary data. This art gallery will also display some examples of paintings, information and products from the country concerned. The Asian Culture Gallery questionnaire has been distributed online to 153 respondents to find out market interest and responses to questions or statements given. From a market perspective, this gallery is worth running.
Keyword: Market, Feasibikity, Gallery, Business
Concentrated Growth Factors Promote hBMSCs Osteogenic Differentiation in a Co-Culture System With HUVECs
Authors: Liao Yunyang , Fang Youran , Zhu Hanghang , Huang Yue , Zou Gengsen , Dai Bowen , Rausch Macro Aoqi , Shi Bin 
Published: March 2022

Osteogenesis is a complex physiologic process that occurs during bone regeneration. This process requires several growth factors that act on bone marrow-derived mesenchymal stem cells (BMSCs). Concentrated growth factor (CGF) is a new-generation platelet-rich derivative that is an appealing autologous material for application in tissue repair and bone regenerative medicine because it contains a variety of fibrin and growth factors. In this study, the effects of CGF on the proliferation and osteogenic differentiation of hBMSCs and human umbilical vein endothelial cells (HUVECs) were explored with in vitro cell co-culture experiments. HBMSCs and HUVECs were directly co-cultured at the ratio of 1:2 under different concentrations (0, 2, 5, 10, 20%) of CGF for 7 days. Alkaline phosphatase (ALP) staining and quantitative reverse transcription polymerase chain reaction were used to detect the effects of CGF on the expression of osteogenic genes (ALP, osteocalcin [OCN], type I collagen [COL-1], Runt-related transcription factor 2 [RUNX2]) and connexin 43 (CX43). RNA sequencing was used to explore potential regulated genes and signaling pathways that affect the osteogenesis of co-cultured hBMSCs exposed to CGF. The results showed higher expressions of ALP, COL-1, RUNX2, OCN, and CX43 in the direct co-culture group containing 10% CGF compared to the direct co-culture group without CGF and the indirect co-culture group. In summary, 10% CGF can significantly promote osteogenesis in hBMSCs directly co-cultured with HUVECs. Intercellular communication between the direct co-culture of hBMSCs and HUVECs through CX43 may be one of the main regulatory mechanisms.
Geochemical and Isotopic Characteristics of Two Geothermal Systems at the Nanpu Sag, Northern Bohai Bay Basin
Authors: Wang Ke , Hua Cong , Ren Lu , Kong Yanlong , Sun Wenjie , Pan Sheng , Cheng Yuanzhi , Huang Yonghui , Tian Fei , Zhang Weizun , Qin Dajun , Ma Feng , Wang Jianwei , Dong Yuexia 
Published: March 2022

The utilization of geothermal energy has gradually increased in northern China because of its unique advantages as a heating supply. However, the sustainable exploitation of geothermal energy usually requires a comprehensive investigation of the geothermal water circulation pattern prevailing at a proposed site. During the exploitation of geothermal energy resources at Nanpu Sag in northern China, thermal anomalies were found to exist in two adjacent regions: the Caofeidian and the Matouying. To reconcile the anomalies and to examine both the source of recharge water and the geothermal systems’ circulation dynamics, a comprehensive investigation was performed using multiple chemical and isotopic tracers (δ2H, δ18O, 87Sr/86Sr, δ13C, and 14C). The total dissolved solids (TDS) of the geothermal water are approximately 750 mg/L and 1,250 mg/L, respectively. The geothermal water isotopes at the two sites are also different, with average values of -9.3‰ and -8.2‰ for δ18O and -73.4‰ and -71‰ for δ2H, respectively. Moreover, the 87Sr/86Sr ratio of geothermal water at Matouying is 0.7185, which is much greater than that of Caofeidian, with an average value of 0.7088. All the results confirm the difference between the two geothermal systems and may explain the two circulation patterns of deep groundwater at Caofeidian and Matouying. The reservoir temperature obtained from theoretical chemical geothermometers is estimated to be 83–92°C at the Caofeidian and 107–137°C at the Matouying, respectively. The corrected 14C age implies a low circulation rate that would allow sufficient time to heat the water at Caofeidian. In addition, we propose a geothermal conceptual model in our study area. This model could provide key information regarding the geothermal sustainable exploitation and the effective management of geothermal resources.
Earthquake Occurrences of the Major Tectonic Terranes for the Arabian Shield and Their Seismic Hazard Implications
Authors: Ali Sherif M. , Abdelrahman Kamal 
Published: March 2022

The Arabian Shield, which contains a group of diverse terranes accreted during the Late Proterozoic, has experienced considerable historical and recent earthquake activities. From north to south, the Midyan terrane, Tabuk-Neom area, Hijaz terrane, Jeddah terrane, and Asir terrane make up the western section of the Arabian shield. In order to determine the earthquake occurrences and earthquake recurrence characteristics in the study area, an earthquake dataset containing 2,991 seismic events recorded between 1941 and 2019 with magnitudes of 1.0 and 6.2 and depths between 0 and 50 km was examined. The data were compiled by combining phase readings and information, such as origin times, hypocenter parameters, and magnitudes reported by the International Seismological Centre. The maximum likelihood method has been applied to calculate the Gutenberg–Richter recurrence parameters (a- and b-values) and magnitudes of completeness (Mc). The range of b-values is 0.53–1.04, which indicates that the study region experienced different stress level accumulations that cause earthquakes with different magnitudes. The Hijaz terrane is characterized by a high b-value (1.04 ± 0.34), which indicates a relatively low stress regime that resulted from the earthquakes stress release. The Midyan terrane is characterized by a low b-value (0.53 ± 0.10), which could be indicative of a relatively higher stress regime associated with a dominantly extensional stress. Mc values were found to be 1.4 in Midyan and Jeddah terranes. The lower value of Mc at Midyan terrane demonstrates appropriate station distribution and high earthquake rates. However, at Jeddah terrane, the seismic activities are poorly detected that probably lead to the small value of Mc. Higher Mc are evident in Hijaz terrane (Mc = 2.3) and Tabuk-Neom (Mc = 2.4), where the station distribution is very poor. The maximum expected magnitudes (Mmax) are found to be 6.0 for Midyan terrane, 5.4 for Tabuk-Neom, 4.7 for Hijaz terrane, 4.8 for Jeddah terrane, and 7.7 for Asir terrane. The average recurrence intervals of earthquakes with the Mmax are ∼7, ∼20, ∼6, ∼120, and ∼200 years for each seismic terrain, respectively. The probability of occurrence and returned periods of different magnitudes in each region indicate that regions related to the Najd strike-slip fault system are the regions for large probable earthquake occurrences.
Role of DTL in Hepatocellular Carcinoma and Its Impact on the Tumor Microenvironment
Authors: Li Zuyin , Wang Rangrang , Qiu Chen , Cao Can , Zhang Jianming , Ge Jun , Shi Yuanping 
Published: March 2022

BackgroundThe crucial role of DTL has been previously implicated in genomic stability; however, its prognostic value and its relation with tumor immunity in hepatocellular carcinoma (HCC) remain to be further explored.MethodsTranscriptional and mutational datasets as well as clinical information were retrieved from the GEO, ICGC, and TCGA databases. Differentially expressed genes (DEGs) were obtained from the comparison of DTLhigh and DTLlow expression groups of the TCGA-HCC cohort. Those genes were under KEGG and gene ontology (GO) analyses to decipher the influence of the DTL gene on the biological behavior of HCC tumor cells. The survival status and mutational characteristics of patients according to DTL levels were depicted and analyzed. The DTL overexpression in HCC and its impact on prognosis were further confirmed by a cohort of 114 HCC patients (validation cohort). The TIMER, GEPIA, and TISIDB databases were adopted to investigate the potential relations between DTL levels and the status of immune cells, as well as immune cell infiltrations.ResultsThe DTL gene is overexpressed in tumor tissues compared with distant non-malignant liver tissues, and DTL overexpression in HCC would enhance the HCC cells in the activities of cell cycle and division. HCC patients with high DTL expression have unfavorable clinical outcomes and harbor more somatic mutations than those with low DTL expression, and multivariate analysis also revealed that DTL overexpression could act as an independent biomarker for prognosis. Moreover, the DTL gene was positively linked to marker sets of infiltrating activated CD8+ and CD4+ T cells; however, these cells demonstrated to be functionally exhausted.ConclusionsPatients with a DTL overexpression phenotype in HCC have poorer prognosis than those in the DTLlow group due to the role of the DTL gene in the process of pro-cell proliferation, accompanied by the immunosuppressive microenvironment and T cell exhaustion.
Effect of Slag Gypsum Binder as a Substitute to Cement on the Stability of Backfill Mining
Authors: Xiaobing Yang , Zepeng Yan , Weiguang Li , Leiming Wang , Shenghua Yin 
Published: March 2022

To effectively apply slag-gypsum binder (SGB) to most modern mines. An experimental study is conducted to investigate the feasibility and reliability of slag-gypsum binder (SGB) to replace cement in the mine backfill to effectively apply SGB in modern mines. The optimum parameters of aggregate and SGB fineness were investigated on a laboratory basis and the effect of concentration on the workability was analyzed. Also, industrial tests were carried out to study the cementitious properties of SGB and compared to cement. Finally, the hydration properties of SGB were analyzed using XRD and SEM. The results indicated that the main hydration products of SGB are C-S-H gel and ettringite, while Ca(OH)2 is consumed during the hydration process. In addition, the structure formed in the later stage of SGB is more compact. SGB is beneficial to the strength of the waste rock mixture. The sample prepared with the waste rock-rod milling sand-river sand mixture has a maximum strength of 7.54 MPa at 28 d. Reducing fineness is beneficial to form early strength. However, a specific surface area exceeding 510 m2/kg will harm the later strength. Surface area is less (400 m2/kg), the sample strength decreases when the dosage increases. Comparing the workability of SGB slurry and cement slurry, it is found that there is no essential difference between them under different mass concentration conditions. SGB slurry shows better fluidity and stability at a mass concentration of 80–82%. Industrial backfill experiments show the 3-, 7-, and 28-d strengths of SGB samples under 80% mass concentration conditions are 0.91 times, 1.43 times, and 1.2 times the cement samples. Therefore, using SGB instead of cement to backfill is a good application prospect.
Levels of Soluble NKG2D Ligands and Cancer History in Patients Starting Hemodialysis
Authors: Nagai Kei , Tawara Takashi , Usui Joichi , Ebihara Itaru , Ishizu Takashi , Kobayashi Masaki , Maeda Yoshitaka , Kobayashi Hiroaki , Yamagata Kunihiro 
Published: March 2022

BackgroundImmune dysfunction in hemodialysis patients is partially due to NK cell impairment. Ligands for NK activating receptors such as NKG2D expressed on cancer cells are involved in NK cell dysfunction and can lead to cancer development.MethodsA cohort with 370 patients who started hemodialysis (HD) was investigated. Serum levels of soluble NKG2D ligands were measured. Cancer history was defined as any cancer diagnosis at induction and hospitalization and death due to cancer during 2-year follow-up.ResultsSixty-two patients with and 308 patients without a cancer history showed mostly comparable biochemical parameters and uremic status at HD induction. Soluble MICB, ULBP-1, and ULBP-2 were detected in sera from most patients starting HD rather than MICA, the most representative NKG2D ligand. Measured NKG2D ligands, except for ULBP-1, were strongly correlated with each other. Correlations between NKG2D ligands and renal function were significant but modest in patients starting HD. Cancer history did not have any impact on levels of soluble NKG2D ligands.DiscussionEven though this investigation lacked a control cohort and serial measurement of parameters, expression patterns of NKG2D ligands were comprehensively described, and the significance of cancer in patients starting HD was elucidated for the first time. Elevated levels of soluble NKG2D ligands occurred potentially due to complex mechanisms of oxidative stress, with insufficient metabolism and excretion in a uremic milieu, but they might mask the significance of elevations in serum levels of soluble NKG2DLs in patients with a cancer history.
Development and Evaluation of the Quality of Life Scale for Children With Visual Impairments in China
Authors: Liu Jie , Evans Richard , Wang Yanjun , Hu Beibei , Tong Yan , Li Shaoqiong , Tian Zhiqiang , Li Jing , Zhang Cuihua , He Lu , Zheng Jianzhong 
Published: March 2022

BackgroundVisual impairments related to non-correctable vision loss, including blindness and low vision, have been consistently shown to lower a person's health-related quality of life. This study assessed the reliability, validity, and discrimination of the Quality of Life Scale for Children with Visual Impairments (QOLS-CVI) in China.MethodsThe Pediatric Quality of Life Inventory™ 4.0 and World Health Organization Quality of Life-Disability Scale for physical disability were selected to define conceptual frameworks and item libraries based on relevant existing studies. According to two rounds of expert consultations and group discussions, some items were modified, and the draft scale was developed. Two item selection processes based on classical test theory and item response theory were used to conduct a preliminary survey and a formal survey in special schools in Shanxi and Hebei Provinces. Finally, the reliability and validity of the quality of life scale for visually impaired children in China were verified.ResultsThe final QOLS-CVI consisted of 38 items, 10 subdomains, and 6 domains. Reliability was verified by Cronbach's alpha coefficient, split-half reliability, and test-retest reliability (Cronbach's alpha for the full scale, 0.841; split-half reliability, 0.629; and test–retest reliability, 0.888). The validity results showed that the multidimensional scale met expectations: exploratory factor analysis and confirmatory factor analysis indicated good fitting models for children with visual impairments.ConclusionsThe QOLS-CVI was determined to be reliable and valid and to have strong feasibility and effectiveness. This scale can be used as an evaluation tool to study the QOL and social-participation ability of children with visual impairments.