bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of lime and oxalic acid on antioxidant enzymes and active components of Panax notoginseng under cadmium stress
Authors: Li Qi , Jiang Na , Mei Xinyue , Zu Yanqun , Li Zuran , Qin Li , Li Bo 
Published: July 2022

AbstractCadmium (Cd) pollution poses potential safety risks for Panax notoginseng cultivation, a medicinal plant in Yunnan. Under exogenous Cd stress, field experiments were conducted to understand the effects of lime (0, 750, 2250 and 3750 kg hm−2) applied and oxalic acid (0, 0.1 and 0.2 mol L−1) leaves sprayed on Cd accumulation, antioxidant system and medicinal components of P. notoginseng. The results showed that Lime and foliar spray of oxalic acid were able to elevate Ca2+ and alleviate Cd2+ toxicity in P. notoginseng under Cd stress. The addition of lime and oxalic acid increased the activities of antioxidant enzymes and alters osmoregulator metabolism. The most significant increase in CAT activities increased by 2.77 folds. And the highest increase of SOD activities was 1.78 folds under the application of oxalic acid. While MDA content decreased by 58.38%. There were very significant correlation with soluble sugar, free amino acid, proline and soluble protein. Lime and oxalic acid were able to increase calcium ions (Ca2+), decrease Cd content and improve the stress resistance of P. notoginseng, while increasing the production of total saponins and flavonoids. Cd content were the lowest, 68.57% lower than controls, and met the standard value (Cd ≤ 0.5 mg kg−1, GB/T 19086-2008). The proportion of SPN was 7.73%, which reached the highest level of all treatments, the flavonoids content increased significantly by 21.74%, which reached the medicinal standard value and optimal yield.
Changes in lifestyles and depressive symptom among patients with chronic diseases during COVID-19 lockdown
Authors: He Wei , Zhao Xueyin , Yang Zhiying , Min Yan , Wu Yi-Hsuan , Kang Qingcong , Frost Eleanor , Gao Peng , Yang Yang , Chen Xinyu , Chen Lijin , Lu Ying , Hsing Ann W. , Zhu Shankuan 
Published: July 2022

AbstractThis study aims to investigate the impact of COVID-19 lockdown on lifestyle behaviors and depressive symptom among patients with NCDs (noncommunicable diseases). We incorporated a COVID-19 survey to the WELL China cohort, a prospective cohort study with the baseline survey conducted 8–16 months before the COVID-19 outbreak in Hangzhou, China. The COVID-19 survey was carried out to collect information on lifestyle and depressive symptom during lockdown. A total of 3327 participants were included in the COVID-19 survey, including 2098 (63.1%) reported having NCDs at baseline and 1457 (44%) without NCDs. The prevalence of current drinkers decreased from 42.9% before COVID-19 lockdown to 23.7% during lockdown, current smokers from 15.9 to 13.5%, and poor sleepers from 23.9 to 15.3%, while low physical activity increased from 13.4 to 25.2%, among participants with NCDs (P < 0.05 for all comparisons using McNemar's test). Participants with NCDs were more likely than those without to have depressive symptom (OR, 1.30; 95% CI 1.05–1.61), especially among those who need to refill their medication during the COVID-19 lockdown (OR, 1.52; 95% CI 1.15–2.02). Our findings provide insight into the development of targeted interventions to better prepare patients with NCDs and healthcare system to meet the challenge of future pandemic and lockdown.
Advances and challenges of operational seasonal prediction in Pacific Island Countries
Authors: Lee Yun-Young , Kim WonMoo , Sohn Soo-Jin , Kim Bo Ra , Seuseu Sunny K. 
Published: July 2022

AbstractSeasonal climate forecasts play a critical role in building a climate-resilient society in the Pacific Island Countries (PICs) that are highly exposed to high-impact climate events. To assist the PICs National Meteorological and Hydrological Services in generating reliable national climate outlooks, we developed a hybrid seasonal prediction system, the Pacific Island Countries Advanced Seasonal Outlook (PICASO), which has the strengths of both statistical and dynamical systems. PICASO is based on the APEC Climate Center Multi-Model Ensemble (APCC-MME), tailored to generate station-level rainfall forecasts for 49 stations in 13 countries by applying predictor optimization and the large-scale relationship-based Bayesian regression approaches. Overall, performance is improved and further stabilized temporally and spatially relative to not only APCC-MME but also other existing operational prediction systems in the Pacific. Gaps and challenges in operationalization of the PICASO system and its incorporation into operational climate services in the PICs are discussed.
Effects of strip cropping with reducing row spacing and super absorbent polymer on yield and water productivity of oat (Avena sativa L.) under drip irrigation in Inner Mongolia, China
Authors: Tian Lu , Liu Jing-hui , Zhang Sheng , Zhao Bao-ping , Mi Jun-zhen , Li Ying-hao , Wang Feng-wu 
Published: July 2022

AbstractWith the serious shortage of water resources and the development of water-saving agriculture, the application of drip irrigation has been paid more and more attention. But there was lack of oat planting methods suitable for drip irrigation, currently. In order to establish an efficient oat planting method for drip irrigation, a study was conducted at Agriculture and Forestry Sciences of Ulanqab, Inner Mongolia during the season (2019–2020) to evaluate the effect of strip cropping with reducing row spacing and super absorbent polymer on the yield and water use efficiency of oat. To conduct the field trials, a split plot system in three replications was established. Three planting patterns were in the main plots, including conventional cropping with 20 cm equal row spacing (PA), strip cropping with the 15 cm row spacing (PB) and strip cropping with the 10 cm row spacing (PC), and two super absorbent polymer levels were in the subplots, including 22.5 kg ha−2 (Y) and 0 (N). The results showed that, compared with PA, PB and PC both decreased the irrigation volumes by 4.5–18.4 mm, and the irrigation volumes of PB was lower than that of PC. When super absorbent polymers were applied, compared with PA, PB significantly increased grain yield and above-ground biomass, but PC had the opposite effects. The grain yield and above-ground biomass of PB significantly increased by 16.65% and 7.31% on average in two years, respectively. And the increasing of grain yield was attributed by the significant increasing of pike number and kernel number per spike. But when super absorbent polymers were not applied, PB had no significant effects on grain yield and above-ground biomass. PB also had the significant effects on regulating water use of oats weather or not super absorbent polymers were applied, it significantly increased the precipitation ratio by 2.64% (PBY) and 2.13% (PBN) and decreased irrigation ration by 3.32% (PBY) and 5.28% (PBN) on average in two years. Although PB and PC both decreased the total evapotranspiration, but PB increased WUE and PC deceased WUE. The WUE of PB increased by 19.70% (PBY) and 9.87% (PBN) on average in two years. Also PB had the highest economic benefits in all treatments. In conclusion, a drip irrigation oat planting pattern was proposed, which the row spacing is 15 cm, adjusted the equal row spacing planting to 8-row strip planting, with a belt spacing of 30 cm, combined with the application of 22.5 kg ha−2 applying super absorbent polymers. And this oat planting pattern is a viable strategy to improve oat productivity.
Prosociality moderates outcome evaluation in competition tasks
Authors: Lu Jiachen , Li Weidong , Xie Yujia , Huang Qian , Li Jingjing 
Published: July 2022

AbstractThe current study investigated the effect of prosociality on outcome evaluation without involving social comparison and reward processing in face-to-face competition tasks. The results showed that when faced with medium and large outcome feedback, the feedback-related negativity (FRN) amplitude induced in high-prosocial individuals was significantly more negative than that of low-prosocial individuals. In addition, the P300 amplitude induced in high-prosocial individuals was smaller than that in low-prosocial individuals in the face of large outcome feedback; hence, the prosociality score was significantly correlated with FRN amplitude. However, there was no significant difference in FRN between high-and low-prosocial individuals in the face of small outcome feedback. It was concluded that individual prosocial traits can moderate outcome evaluation.
Vision transformer and explainable transfer learning models for auto detection of kidney cyst, stone and tumor from CT-radiography
Authors: Islam Md Nazmul , Hasan Mehedi , Hossain Md. Kabir , Alam Md. Golam Rabiul , Uddin Md Zia , Soylu Ahmet 
Published: July 2022

AbstractRenal failure, a public health concern, and the scarcity of nephrologists around the globe have necessitated the development of an AI-based system to auto-diagnose kidney diseases. This research deals with the three major renal diseases categories: kidney stones, cysts, and tumors, and gathered and annotated a total of 12,446 CT whole abdomen and urogram images in order to construct an AI-based kidney diseases diagnostic system and contribute to the AI community’s research scope e.g., modeling digital-twin of renal functions. The collected images were exposed to exploratory data analysis, which revealed that the images from all of the classes had the same type of mean color distribution. Furthermore, six machine learning models were built, three of which are based on the state-of-the-art variants of the Vision transformers EANet, CCT, and Swin transformers, while the other three are based on well-known deep learning models Resnet, VGG16, and Inception v3, which were adjusted in the last layers. While the VGG16 and CCT models performed admirably, the swin transformer outperformed all of them in terms of accuracy, with an accuracy of 99.30 percent. The F1 score and precision and recall comparison reveal that the Swin transformer outperforms all other models and that it is the quickest to train. The study also revealed the blackbox of the VGG16, Resnet50, and Inception models, demonstrating that VGG16 is superior than Resnet50 and Inceptionv3 in terms of monitoring the necessary anatomy abnormalities. We believe that the superior accuracy of our Swin transformer-based model and the VGG16-based model can both be useful in diagnosing kidney tumors, cysts, and stones.
T4 reduces cisplatin resistance by inhibiting AEG-1 gene expression in lung cancer cells
Authors: Song Tian-jiao , Lin Xiao-hong , Huang Ping-ting , Chen Yu-qing , Chen Li-min 
Published: July 2022

AbstractLung cancer is the most malignant form of cancer and has the highest morbidity and mortality worldwide. Due to drug resistance, the current chemotherapy for lung cancer is not effective and has poor therapeutic effects. Tripchlorolide (T4), a natural extract from the plant Tripterygium wilfordii, has powerful immunosuppressive and antitumour effects and may become a potential therapeutic agent for lung cancer. Therefore, this study aimed to investigate the effect of T4 on reducing chemoresistance in lung cancer cells and to explore the mechanism. 1. A549 and A549/DDP cells were separately transfected with AEG-1 overexpression and AEG-1 knockdown plasmids. A549/DDP cells were divided into the A549/DDP empty group, T4 group, and T4 + AEG-1 overexpression group. A CCK-8 assay was used to evaluate the proliferation of cells in each group. RT–qPCR and Western blotting were used to detect the expression of AEG-1 and MDR-1. Expression of AEG-1 in A549 and A549/DDP cells was positively correlated with cisplatin resistance. When the AEG-1 protein was overexpressed in A549 cells, the lethal effect of cisplatin on A549 cells was attenuated (all P < 0.05). After the AEG-1 protein was knocked down in A549/DDP cells, cisplatin was applied. The lethal effect was significantly increased compared to that in the corresponding control cells (all P < 0.05). AEG-1 protein expression gradually decreased with increasing T4 concentration in A549 and A549/DDP cells. Resistance to cisplatin was reduced after the addition of T4 to A549/DDP cells (P < 0.05), and this effect was enhanced after transfection with the AEG-1 knockdown plasmid. T4 plays an important role in increasing the sensitivity of lung cancer cells to cisplatin.
Eco-evolutionary model on spatial graphs reveals how habitat structure affects phenotypic differentiation
Authors: Boussange Victor , Pellissier Loïc 
Published: July 2022

AbstractDifferentiation mechanisms are influenced by the properties of the landscape over which individuals interact, disperse and evolve. Here, we investigate how habitat connectivity and habitat heterogeneity affect phenotypic differentiation by formulating a stochastic eco-evolutionary model where individuals are structured over a spatial graph. We combine analytical insights into the eco-evolutionary dynamics with numerical simulations to understand how the graph topology and the spatial distribution of habitat types affect differentiation. We show that not only low connectivity but also heterogeneity in connectivity promotes neutral differentiation, due to increased competition in highly connected vertices. Habitat assortativity, a measure of habitat spatial auto-correlation in graphs, additionally drives differentiation under habitat-dependent selection. While assortative graphs systematically amplify adaptive differentiation, they can foster or depress neutral differentiation depending on the migration regime. By formalising the eco-evolutionary and spatial dynamics of biological populations on graphs, our study establishes fundamental links between landscape features and phenotypic differentiation.
Making cough count in tuberculosis care
Authors: Zimmer Alexandra J. , Ugarte-Gil César , Pathri Rahul , Dewan Puneet , Jaganath Devan , Cattamanchi Adithya , Pai Madhukar , Grandjean Lapierre Simon 
Published: July 2022

AbstractCough assessment is central to the clinical management of respiratory diseases, including tuberculosis (TB), but strategies to objectively and unobtrusively measure cough are lacking. Acoustic epidemiology is an emerging field that uses technology to detect cough sounds and analyze cough patterns to improve health outcomes among people with respiratory conditions linked to cough. This field is increasingly exploring the potential of artificial intelligence (AI) for more advanced applications, such as analyzing cough sounds as a biomarker for disease screening. While much of the data are preliminary, objective cough assessment could potentially transform disease control programs, including TB, and support individual patient management. Here, we present an overview of recent advances in this field and describe how cough assessment, if validated, could support public health programs at various stages of the TB care cascade.
TCF7 is highly expressed in immune cells on the atherosclerotic plaques, and regulating inflammatory signaling via NFκB/AKT/STAT1 signaling
Authors: Ma Zhongnan , Wang Chuang , Bai Xiufeng , Wang Long , Wu Qianjing , Cai Zehong , Wang Wanxiang , Ma Zhuo , Liu Xinyu , Feng Jiaxuan , Feng Rui 
Published: July 2022

Abstract
Atherosclerosis, which is the fundamental basis for cardiovascular diseases in the global world, is driven by multiple roles of the immune system in the circulation and vascular plaque. Recent studies demonstrated that T-cell infiltrates into aorta plaque and plays an important role in recruiting macrophages to the vascular wall. Here, using single-cell sequencing, we found T cells in patients’ plaques and differentially expressed genes (DEGs) of T cells in atherosclerosis mice. T cells and macrophages were continuously activated in atherosclerotic plaque in patients. Besides, other immune cells also take part in atherogenesis, such as natural killer (NK) cells, granulocytes. Interferon (IFN)/NFκB signaling, the AKT signaling pathway was highly activated in mouse (in vivo) and cell line (in vitro). TCF7 and XCL1 were regulated by AKT and NFκB, respectively through protein–protein network analysis. Therefore, we attempt to clarify and discover potential genes and new mechanisms associated with atherosclerosis for drug development.
Investigation on overvoltage caused by vacuum circuit breaker switching off shunt reactor in offshore wind farms
Authors: Zheng Zhi , Sun Qiuqin , Yang Jianlan , Chen She , Wang Feng , Zhong Lipeng 
Published: July 2022

AbstractThe multiple reignitions of vacuum circuit braker (VCB) while switching off the shunt reactor in an offshore wind farm (OWF) would produce a high overvoltage. The post‐arc process of ion movement in the vacuum interrupter is analysed. Considering the sheath growth and ion concentration variation, the expression for dielectric recovery strength inside the VCB interrupter is derived. A novel VCB model is implemented in the environment of electromagnetic transient programme based on the new reignition criterion. Then, the switching overvoltage is computed and analysed in detail. For the OWF with high rising rate of transient recovery voltage, the sheath growth must be considered in the VCB model; otherwise, the overvoltage may be underestimated. Using resistor–capacitor (RC) snubber, a new installation scheme is proposed to suppress the overvoltage in the OWF. The results indicate that the proposed scheme can not only reduce the peak and steepness of overvoltage but also damp the high‐frequency oscillation. It would not affect the steady‐state operation of OWF. Besides, the capacitor of RC snubber normally does not bear the electric stress, and its life expectancy would be greatly enhanced.
Galaxies in the central regions of simulated galaxy clusters
Authors: Ragagnin Antonio , Meneghetti Massimo , Bassini Luigi , Ragone-Figueroa Cinthia , Luigi Granato Gian , Despali Giulia , Giocoli Carlo , Granata Giovanni , Moscardini Lauro , Bergamini Pietro , Rasia Elena , Valentini Milena , Borgani Stefano , Calura Francesco , Dolag Klaus , Grillo Claudio , Mercurio Amata , Murante Giuseppe , Natarajan Priyamvada , Rosati Piero , Taffoni Giuliano , Tornatore Luca , Tortorelli Luca 
Published: July 2022

Context. Recent observations found that observed cluster member galaxies are more compact than their counterparts in ΛCDM hydrodynamic simulations, as indicated by the difference in their strong gravitational lensing properties, and they reported that measured and simulated galaxy–galaxy strong lensing events on small scales are discrepant by one order of magnitude. Among the possible explanations for this discrepancy, some studies suggest that simulations with better resolution and implementing different schemes for galaxy formation could produce simulations that are in better agreement with the observations.
Aims. In this work, we aim to assess the impact of numerical resolution and of the implementation of energy input from AGN feedback models on the inner structure of cluster sub-haloes in hydrodynamic simulations.
Methods. We compared several zoom-in re-simulations of a sub-sample of cluster-sized haloes obtained by varying mass resolution and softening the length and AGN energy feedback scheme. We studied the impact of these different setups on the sub-halo (SH) abundances, their radial distribution, their density and mass profiles, and the relation between the maximum circular velocity, which is a proxy for SH compactness
Results. Regardless of the adopted numerical resolution and feedback model, SHs with masses of MSH ≲ 1011 h−1 M⊙, the most relevant mass range for galaxy–galaxy strong lensing, have maximum circular velocities ∼30% smaller than those measured from strong lensing observations. We also find that simulations with less effective AGN energy feedback produce massive SHs (MSH ≳ 1011 h−1 M⊙) with higher maximum circular velocity and that their Vmax − MSH relation approaches the observed one. However, the stellar-mass number count of these objects exceeds the one found in observations, and we find that the compactness of these simulated SHs is the result of an extremely over-efficient star formation in their cores, also leading to larger than observed SH stellar mass.
Conclusions. Regardless of the resolution and galaxy formation model adopted, simulations are unable to simultaneously reproduce the observed stellar masses and compactness (or maximum circular velocities) of cluster galaxies. Thus, the discrepancy between theory and observations that emerged previous works. It remains an open question as to whether such a discrepancy reflects limitations of the current implementation of galaxy formation models or the ΛCDM paradigm.
Minimally Invasive Tubular Retractor Surgery for Intradural Extramedullary Spinal Tumor Reduces Postoperative Degeneration of Paraspinal Muscle
Authors: He Zhexi , Li Cho Ying , Mak Calvin Hoi-Kwan , Tse Tat Shing , Cheung Fung Ching 
Published: July 2022

Abstract
Background Minimally invasive surgery (MIS) using a tubular retractor has been increasingly utilized in spinal surgery for degenerative conditions with the benefit of paraspinal muscle preservation. This benefit has not been previously reported for intradural extramedullary tumors using the MIS approach. In this study, we aimed to compare the degree of postoperative fatty degeneration in paraspinal muscle between MIS with tubular retractor (MIS) and open laminectomy (Open) for intradural extramedullary spinal tumors.
Methods This was a retrospective review conducted in a tertiary neurosurgical center from 2015 to 2019. The degree of paraspinal muscle fatty degeneration, as measured by Goutallier grade on postoperative magnetic resonance imaging (MRI), was analyzed, and the degree of excision, tumor recurrence rate, and chronic pain were compared between the two surgical approaches.
Results Among 9 patients in the MIS group and 33 patients in the Open group, the rate of gross total resection was comparable (MIS: 100.0%, Open: 97.0%, p = 1.000). The degree of paraspinal muscle fatty degeneration was significantly reduced in the MIS group (median Goutallier grade 1 in MIS group vs. median Goutallier grade 2 in Open group, p = 0.023). There was no significant difference in the tumor recurrence rate, complication rate, and chronic pain severity. A consistent trend of reduced analgesic consumption was observed in the MIS group, though not statistically significant.
Conclusions Minimally invasive tubular retractor surgery is an effective approach for appropriately selected intradural extramedullary spinal tumors with significantly reduced postoperative fatty degeneration in paraspinal muscle.