bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of acarbose therapeutic efficacy in newly diagnosed type 2 diabetes mellitus patients in China
Authors: Zhang Rong , Zhao Quanxi , Li Rong 
Published: October 2022

Abstract
Background
Acarbose is one of the optimal drugs for patients with the first diagnosis of type 2 diabetes mellitus (T2DM). But what kind of emerging patients has the best therapeutic response to acarbose therapy has never been reported. To this end, we investigated predictors of acarbose therapeutic efficacy in newly diagnosed T2DM patients in China.

Methods
A total of 346 T2DM patients received acarbose monotherapy for 48 weeks as part of participating in the Study of Acarbose in Newly Diagnosed Patients with T2DM in China (MARCH study) from November 2008 to June 2011. Change in glycated hemoglobin (ΔHbA1c) served as a dependent variable while different baseline variables including sex, age, disease duration, weight, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), HbA1c, fasting plasma glucose (FPG), 2-h postprandial blood glucose (2 h PG), fasting insulin (FINS), 2-h postprandial insulin (2 h INS), early insulin secretion index (IGI), homeostasis model assessment of insulin resistance index (HOMA-IR), homeostasis model assessment of beta cell function (HOMA-B), area under the curve (AUC) of glucagon, insulin and GLP-1 were assessed as independent predictors. Step-wise multiple linear regression was employed for statistical analysis.

Results
The results suggested that independent predictors of ΔHbA1c at 12 weeks included baseline body weight (β = − 0.012, P = 0.006), DBP (β = 0.010, P = 0.047), FPG (β = 0.111, P = 0.005) and 2 h PG (β = 0.042, P = 0.043). Independent predictors of ΔHbA1c at 24 weeks included disease duration (β = 0.040, P = 0.019) and FPG (β = 0.117, P = 0.001). Finally, independent predictor of ΔHbA1c at 48 weeks was disease duration (β = 0.038, P = 0.046).

Conclusions
Acarbose may be more effective in newly diagnosed T2DM patients with low FPG, low 2 h PG and obesity. The earlier T2DM is diagnosed and continuously treated with acarbose, the better the response to therapy.
Heat flow data and thermal structure in northeastern Japan
Authors: Matsumoto Takumi , Yamada Ryuji , Iizuka Satoshi 
Published: October 2022

AbstractNew heat flow data corrected for climate change over Northeastern Japan were obtained using the temperature profile of the borehole of the High Sensitivity Seismograph Network (Hi-net). The obtained spatial distribution of heat flow shows low heat flow on the forearc side, high heat flow along the Ou Backbone Range, and low heat flow in the plains on the back-arc side. However, the distribution is not clearly divided into high and low heat flow along the VF front; for example, the low heat flow extends from near the northern Kitakami Mountains on the forearc side to the Ou Backbone Range crossing the VF, while the high heat flow extends to the central Kitakami Mountains and Sendai plain on the forearc side. In addition, a crustal temperature structure model was developed that considers into account the presence of sedimentary layers, the temperature dependence of thermal conductivity, and differences in heat generation due to lithology. There is a good correlation between this temperature structure and the lower limit of the seismogenic layer, which is between 400 and 450 °C. Compared to previous studies, the crustal thermal structure calculation method assumed is a model whose estimated temperature distribution is sensitive to structural differences; however, a more accurate estimation of the temperature structure is possible if detailed structural information is available. On the other hand, it seems necessary to treat fluid behavior in more detail in areas of high heat flow. However, the estimation of crustal temperature structure, especially in regions with thick sedimentary layers, is considered an improvement over the previous study.
Graphical Abstract
TriDFusion (3DF) image viewer
Authors: Lafontaine Daniel , Schmidtlein C. Ross , Kirov Assen , Reddy Ryan P. , Krebs Simone , Schöder Heiko , Humm John L. 
Published: October 2022

AbstractBackgroundAn open-source, extensible medical viewing platform is described, called the TriDFusion image viewer (3DF). The 3DF addresses many broad unmet needs in nuclear medicine research; it provides a viewer with several tools not available in commercial nuclear medicine workstations, yet invaluable for imaging in research studies.ResultsThe 3DF includes an image integration platform to register images from multiple imaging modalities together with delineated volumes of interest (VOIs), structures and dose distributions. It can process images from different vendors’ systems and is therefore vendor neutral. The 3DF also provides a convenient tool for performing multi-modality image analysis and fusion. The functional components currently being distributed is open-source code that includes: (1) a high quality viewer that can display axial, coronal, and sagittal tomographic images, maximum intensity projection images, structure contours, and isointensity contour lines or dose colorwash, (2) multi-image fusion allowing multiple images to be fused with VOI and dose distributions, (3) a suite of segmentation tools to edit and/or create tumor and organ VOIs, (4) dosimetry tools for several radioisotopes, (5) clinical tools for correcting acquisition errors, including patient orientation, and (6) the ability to save the resultant image and VOI as DICOM files or to export the numerical results as comma separated values files. Because the code is written in MATLAB™, it is highly readable and is easier for the coder to make changes compared to languages such as C or C++. In what follows, we describe the content of the new TriDFusion (3DF) image viewer software platform using examples of a number of clinical research workflows. Such examples vary in complexity but illustrate the main attributes of the software.ConclusionsIn summary, 3DF provides a powerful, convenient, easy-to-use suite of open-source imaging research tools for the nuclear medicine community that allows physicians, medical physicists, and academic researchers to display, manipulate, and analyze images.
Vitamin D status in Psoriasis: impact and clinical correlations
Authors: Bhat Ghulam Hassan , Guldin Sadaf , Khan Mosin Saleem , Yasir Mir , Prasad Ganesh 
Published: October 2022

AbstractPsoriasis is a continuing, periodic, immune‑mediated, fiery skin disease branded by hyper proliferation of epidermal keratinocytes and accompanying with inflammatory cellular infiltrate in both dermis and epidermis. Immunomodulation could be an important effect of vitamin D in Psoriasis. This case-control study was designed to measure serum 25-hydroxy vitamin D levels in patients with psoriasis and healthy controls and to find out clinical correlation, if any. Six hundred two (n = 602) subjects (285 cases and 317 controls) were taken for the study. Cases and controls were frequency matched with respect to age and gender. Various demographic and clinical details were taken using a questionnaire. Chemiluminescence Micro Particle Immunoassay was used to estimate serum 25-hydroxy vitamin D levels. The vitamin D deficiency in psoriasis patients was 60.0% vs. 17.5% in controls (P < 0.001) with mean vitamin D levels of 28.3 ± 13.9 ng/ml in psoriasis patient’s vs. 37.9 ± 9.7 ng/ml in controls. Vitamin D deficiency was found to be associated with psoriasis independently of gender, age, smoking status, family history, hypertension, chronic medication, nail changes, duration of symptoms and severity of disease. Vitamin D levels were seven times lower in patients with Psoriasis as compared to controls. Reduced vitamin D levels are related to duration and clinical severity of the disease. Early detection of vitamin D deficiency and timely intervention could lead to better clinical outcome and improved quality of life in psoriasis patients.
Intravitreal aflibercept for the treatment of patients with neovascular age-related macular degeneration in routine clinical practice in Latin America: the AQUILA study
Authors: Wu Lihteh , Bordon Arnaldo F. , Charles Martin , Rodríguez Francisco J. , Lee JinKyung , Machewitz Tobias , Mueller Margarete , del Carmen Gay Gabriela , Fromow-Guerra Jans ,   the AQUILA investigators
Published: October 2022

Abstract
Background
AQUILA (NCT03470103) was a prospective, observational, 12-month cohort study evaluating treatment patterns, clinical effectiveness, and safety of intravitreal aflibercept (IVT-AFL) in patients from Latin America with neovascular age-related macular degeneration (nAMD).

Methods
Treatment-naïve and previously treated (switching to IVT-AFL) patients (aged  ≥ 55 years) were enrolled from March 2018, with a primary completion date of September 2020, from Argentina, Colombia, Costa Rica, and Mexico. Patients received IVT-AFL in a routine clinical practice setting.

Results
Of 274 patients in the full analysis set, 201 were treatment-naïve and 73 had received previous treatment. The mean ± standard deviation number of IVT-AFL injections received by month 12 was 4.2 ± 1.9 (treatment-naïve) and 5.2 ± 2.7 (previously treated). The median duration from diagnosis to IVT-AFL treatment was 1.2 months (treatment-naïve) and 19.5 months (previously treated). Mean best-corrected visual acuity (BCVA) (Early Treatment Diabetic Retinopathy Study [ETDRS] letters) improved from baseline to month 12 by + 5.2 ± 18.3 (treatment-naïve; baseline: 48.2 ± 23.5) and + 3.1 ± 15.3 letters (previously treated; baseline: 47.7 ± 21.4).

Conclusion
AQUILA is the first study to assess the use of IVT-AFL in routine clinical practice in Latin America. Mean BCVA and other visual acuity outcomes improved in both treatment groups, despite many patients not receiving the IVT-AFL label-recommended regimen of three initial monthly doses, or seven or more injections in 12 months. Patients who did receive the label-recommended number of injections had numerically greater improvements in visual acuity outcomes. Patients with nAMD treated regularly and more frequently with IVT-AFL, therefore, have the potential to achieve outcomes consistent with those observed in interventional studies.
Trial registration: Clinicaltrials.gov, NCT03470103. Registered February 5, 2018, https://clinicaltrials.gov/ct2/show/NCT03470103
Mental health and spiritual well-being in humanitarian crises: the role of faith communities providing spiritual and psychosocial support during the COVID-19 pandemic
Authors: Goodwin Ellen , Kraft Kathryn 
Published: October 2022

AbstractAcross the globe, people’s reactions to the COVID-19 pandemic and its accompanying lockdowns highlighted, and continued to stress, the relevance of mental health and psychosocial support (MHPSS) in responding to crises, including in low-income and emergency settings. They also demonstrated the importance of faith practices and communities of faith as core needs and important coping mechanisms for many affected people in times of crisis. Drawing on data collected by World Vision International, the world’s largest child-focused humanitarian and development organisation, in the course of its response to COVID-19 in 70 different countries, this article explores the ways in which faith groups and faith leaders responded to the perceived needs of their communities. While keen to offer psychosocial support to people suffering anxiety and fear in the context of the crisis, this has often been integrated with spiritual support. Analysing their work from the framework of a rights-based approach to mental health, we conclude that they did contribute to psychosocial support through their MHPSS, in part through their provision of spiritual care. However, spiritual well-being should not be conflated with psychosocial well-being. While faith groups play an important role in MHPSS, their primary role is to offer spiritual care.
Online estimation of SOH for lithium-ion battery based on SSA-Elman neural network
Authors: Guo Yu , Yang Dongfang , Zhang Yang , Wang Licheng , Wang Kai 
Published: October 2022

AbstractThe estimation of state of health (SOH) of a lithium-ion battery (LIB) is of great significance to system safety and economic development. This paper proposes a SOH estimation method based on the SSA-Elman model for the first time. To improve the correlation rates between features and battery capacity, a method combining median absolute deviation filtering and Savitzky–Golay filtering is proposed to process the data. Based on the aging characteristics of the LIB, five features with correlation rates above 0.99 after data processing are then proposed. Addressing the defects of the Elman model, the sparrow search algorithm (SSA) is used to optimize the network parameters. In addition, a data incremental update mechanism is added to improve the generalization of the SSA-Elman model. Finally, the performance of the proposed model is verified based on NASA dataset, and the outputs of the Elman, LSTM and SSA-Elman models are compared. The results show that the proposed method can accurately estimate the SOH, with the root mean square error (RMSE) being as low as 0.0024 and the mean absolute percentage error (MAPE) being as low as 0.25%. In addition, RMSE does not exceed 0.0224 and MAPE does not exceed 2.21% in high temperature and low temperature verifications.
Dora's mother: a housewife's psychosis
Authors: Menon Anuradha 
Published: October 2022

SummaryI examine a speculative diagnosis made by Sigmund Freud regarding his patient's mother in his landmark 1905 paper describing a hysterical illness. Freud considered the impact of Dora's mother's mental state on her daughter, wondering whether the mother might suffer from a ‘housewife's psychosis’. Here was an emphasis on the social structures of the times and differences between the parents in terms of sexual freedom and societal limitations placed on women. Freud's description drew attention to Dora's anxieties in relation to her parents, in particular the state of their sexual relationship and the apparently sanctioned entry of another couple, Frau and Herr K, into the parental relationship. In particular, the role of syphilis in the aetiology of sexual disturbances was considered, affecting men and their sexual partners, specifically their wives, who faced lifelong risks of morbidity, inadequate treatment and psychic disturbances at this time in 19th century Vienna.
Hazardous use of benzodiazepine receptor agonists in psychiatric clinics in China: electronic prescription database study
Authors: Xu Xiaomin , Wang Xuyi , Zhong Na , Xu Jiajun , Li Chuanwei , Wang Gang , Wang Wenzhe , Ye Yujian , Chen Yong , Liu Tieqiao , Zhao Min , Jiang Haifeng 
Published: October 2022

BackgroundBenzodiazepine receptor agonists (BZRAs) are commonly used clinically and data on their hazardous use from large populations of psychiatric patients is limited.AimsTo assess the current status of hazardous BZRA use and related factors in Chinese out-patient psychiatric settings.MethodThe study included out-patients with at least one BZRA prescription from five psychiatric settings in east, central and west China in 2018. Demographic and prescription information were extracted from the electronic prescription database. We defined the co-occurrence of overdose and long-term use as hazardous use, and patients whose recorded diagnoses did not meet any indications approved by the Chinese Food and Drug Administration as over-indication users. Additionally, 200 hazardous users were randomly selected for follow-up interview to confirm the actual situation.ResultsAmong 720 054 out-patients, 164 450 (22.8%) had at least one BZRA prescription; 55.9% of patients were prescribed over-indication and 3% were defined as hazardous users. Multilevel multivariate regression analysis with hospital as a random effect showed that factors associated with hazardous use were older age (18–64 years: β = 0.018; 95% CI 0.013–0.023; >65 years: β = 0.015; 95% CI 0.010–0.021), male (β = 0.005, 95% CI 0.003–0.007), over-indication (β = 0.013, 95% CI 0.012–0.015), more out-patient visits (β = 0.006, 95% CI 0.006–0.006) and more visits to different doctors (β = 0.007, 95% CI 0.007–0.008); 98.5% of hazardous users (197/200) could not be contacted.ConclusionsBZRAs are commonly used and there is a relatively large proportion of over-indication users among Chinese psychiatric out-patients. However, only a small proportion of hazardous users were detected. The study highlights how to use prescription data to support improvements in clinical practice.
Dissipative instabilities in beam-plasma systems
Authors: Rostomyan Eduard V. 
Published: October 2022

Abstract
It is known that all types of beam-plasma instabilities (Cherenkov, cyclotron, etc.) at a high level of dissipation turn into dissipative instability (DI). Until recently, only one type of DI was known in the beam-plasma interaction theory. Its maximal growth rate depends on the beam density n

b
and the collision frequency ν in the plasma as

. However, recent studies have shown the existence of two new, previously unknown types of DI. Here, the new DI are briefly justified from the same viewpoint. This became possible due to the developed approach, which makes it possible to solve completely the classical problem of the development of an initial perturbation for various flow instabilities. The first new DI arises in the results of solving of the problem in systems with weak beam-plasma coupling. Its maximal growth rate is inversely proportional to frequency of collisions in plasma

. The second new DI manifests itself in the results of the same problem in a magnetized plasma waveguide with an over-limiting e-beam. Its maximal growth rate is

. Besides, the presented method of solving the classical problem deserves attention in itself as it is applicable to all instabilities caused by relative motion of plasma components (all types of beam-plasma instabilities, Buneman instability, etc.).
Research Note: Intergenerational Transmission Is Not Sufficient for Positive Long-Term Population Growth
Authors: Arenberg Samuel , Kuruc Kevin , Franz Nathan , Vyas Sangita , Lawson Nicholas , LoPalo Melissa , Budolfson Mark , Geruso Michael , Spears Dean 
Published: October 2022

Abstract
All leading long-term global population projections agree on continuing fertility decline, resulting in a rate of population size growth that will continue to decline toward zero and would eventually turn negative. However, scholarly and popular arguments have suggested that because fertility transmits intergenerationally (i.e., higher fertility parents tend to have higher fertility children) and is heterogeneous within a population, long-term population growth must eventually be positive, as high-fertility groups come to dominate the population. In this research note, we show that intergenerational transmission of fertility is not sufficient for positive long-term population growth, for empirical and theoretical reasons. First, because transmission is imperfect, the combination of transmission rates and fertility rates may be quantitatively insufficient for long-term population growth: higher fertility parents may nevertheless produce too few children who retain higher fertility preferences. Second, today even higher fertility subpopulations show declining fertility rates, which may eventually fall below replacement (and in some populations already are). Therefore, although different models of fertility transmission across generations reach different conclusions, depopulation is likely under any model if, in the future, even higher fertility subpopulations prefer and achieve below-replacement fertility. These results highlight the plausibility of long-term global depopulation and the importance of understanding the possible consequences of depopulation.
Locoregionally Recurrent Colon Cancer: How Far Have We Come? A Population-Based, Retrospective Cohort Study
Authors: Swartjes Hidde , van Lankveld Daan W. P. , van Erning Felice N. , Verheul Henk M. W. , de Wilt Johannes H. W. , Koëter Tijmen , Vissers Pauline A. J. 
Published: October 2022

Abstract
Background
The reported outcomes of locoregionally recurrent colon cancer (LRCC) are poor, but the literature about LRCC is scarce and aged. Recent population-based studies to provide current insight into LRCC are warranted. This study aimed to provide an overview of the incidence, risk factors, treatment, and overall survival (OS) of patients with LRCC after curative resection of stage I–III primary colon cancer.

Methods
Data on disease recurrence were collected for all patients with a diagnosis of non-metastasized primary colon cancer in the Netherlands during the first 6 months of 2015. Patients who underwent surgical resection (N = 3544) were included in this study. The 3-year cumulative incidence, risk factors, treatment, and OS for patients with LRCC were determined.

Results
The 3-year cumulative incidence of LRCC was 3.8%. Synchronous distant metastases (LRCC-M1) were diagnosed in 62.7% of the patients. The risk factors for LRCC were age of 70 years or older, pT4, pN1-2, and R1-2. Adjuvant chemotherapy was associated with a decreased risk of LRCC for high-risk stage II and stage III patients [hazard ratio (HR), 0.47; 95% confidence interval (CI) 0.31–0.93]. The median OS for the patients with LRCC was 13.1 months (95% CI 9.1–18.3 months). Curative-intent treatment was given to 22.4% of the LRCC patients, and the subsequent 3 years OS was 71% (95% CI 58–87%). The patients treated with palliative treatment and best supportive care showed 3-year OS rates of 15% (95% CI 7.0–31%) and 3.7% (95% CI 1.0–14%), respectively.

Conclusions
The cumulative incidence of LRCC was low, and adjuvant chemotherapy was associated with a decreased risk for LRCC among targeted patients. Curative-intent treatment was given to nearly 1 in 4 LRCC patients, and the OS for this group was high.
Quality of life of Jordanian menopausal working and retired women and its associated factors: a cross-sectional study
Authors: Assaf Enas A. , Gharaibeh Muntaha K. , Abuhammad Sawsan , AbuRuz Mohannad 
Published: October 2022

Objective: Life expectancy of Jordanian women has increased, indicating that the number of women entering menopausal age, during the prime of their working life, will also increase. Therefore, assessments of the quality of life (QoL) of working and retired women and factors associated with overall wellbeing, are essential for the provision of quality services and care. Method: A cross-sectional study was conducted with 200 Jordanian women between the ages of 45 to 60 years old. The Utian QOL tool was used to assess the quality of life among menopausal women. Multiple regressions were used to determine predictors for QoL for the whole sample and for each group of working and retired women. Results: The study shows that the total QoL for women was 77.5 ±14.4, with a significant difference (p=.023) in total QoL and the occupational domain (p=.003) between working and retired women. Employed women with fewer chronic diseases and using frequent preventive measures had a higher QoL compared to others. Conclusion: Working itself might be an important indicator for better a quality of life among menopausal women. Better working conditions and more attention from the health care providers for the menopausal changes and the preventive measures could enhance women’s perceived QoL in addition to increasing their productivity.