bluuebunny/crossref_metadata_2025_split huggingface dataset:
Walking the Talk? Managing Errors in the Audit Profession*
Authors: Gold Anna , Detzen Dominic , van Mourik Oscar , Wallage Philip , Wright Arnold 
Published: May 2022

ABSTRACTErrors reflect unintended deviations from plans or goals and commonly carry negative connotations. Although errors cannot be eliminated, they offer opportunities for learning and innovation. Audit firms employ powerful mechanisms, such as review processes, to prevent or detect audit errors and safeguard their work in the public interest. At the same time, the profession recognizes positive long‐term outcomes of errors in terms of continuous learning to enhance auditor skills and, ultimately, audit quality. The current study employs semistructured interviews with Dutch auditors to investigate how they manage the tensions emanating from extant public and regulatory demands for flawless audits while embracing errors as opportunities for learning. Our findings reveal that auditors express a positive attitude toward openly communicating audit errors, but, in substance, they espouse negative emotions and defensive strategies for fear of repercussions. We argue that the excessive emphasis audit firms and oversight bodies place on error prevention conditions auditors into perceiving errors as negative and avoidable events. We assert these attitudes result from the profession's efforts to maintain status and legitimacy in the eyes of the public and the regulator, where any auditor error may shed doubt on auditors' work in the public interest. In sum, our findings indicate that viewing errors as incompatible with audit work makes the profession susceptible not only to repeating errors but also to missing out on opportunities to improve services and to achieve innovation.
Aphid‐parasitoids trophic relationship in a cereal crop succession system: Population oscillation and food webs
Authors: dos Santos Carlos Diego Ribeiro , Lau Douglas , Redaelli Luiza Rodrigues , Jahnke Simone Mundstock , Pereira Paulo Roberto Valle da Silva , Engel Eduardo , Sampaio Marcus Vinicius 
Published: May 2022

Abstract
In the 1970s, cereal aphids populations (specially Metopolophium dirhodum) were out of balance in the subtropical region of South America and a successful biological control program with the introduction of parasitoids restored equilibrium. After that, changes in crop systems may have affected aphid‐parasitoid communities.
The objective of this work was to evaluate the current assemblage of cereal aphid parasitoids, describing their oscillations, parasitism level, and trophic relationships in food webs in a cereal succession system (wheat‐corn‐oat) currently adopted in this region.
Over a year, the associated parasitoid/hyperparasitoid species were inventoried by field‐exposed Rhopalosiphum padi, Schizaphis graminum, M. dirhodum, and Sitobion avenae (recruitment method) and by Moericke traps.
Six species of primary parasitoids were sampled in both aphids and traps with the same abundance sequence: A. platensis, A. rhopalosiphi, L. testaceipes, D. rapae, A. uzbekistanicus, and A. ervi.
Parasitism and complexity of food webs were higher during the wheat season (winter–spring), decreasing in corn (summer) and increasing again in oat (autumn).
In the current assemblage of cereal aphid parasitoids in the subtropical region of South America, three species of parasitoids that were already present before the biological control program and three that were introduced oscillate in abundance throughout the year, resulting in an alternation of the complexity of the food webs and in the levels of parasitism in the crop seasons. A. platensis and A. rhopalosiphi are the most abundant species and A. rhopalosiphi remains fundamental in the control of M. dirhodum and S. avenae.
Systemic hormonal contraception and risk of venous thromboembolism
Authors: Heikinheimo Oskari , Toffol Elena , Partonen Timo , But Anna , Latvala Antti , Haukka Jari 
Published: May 2022

AbstractIntroductionThe increased risk of venous thromboembolism associated with the use of hormonal contraception is well recognized, but evidence regarding hormonal contraception containing natural estradiol is limited. This study aimed to assess the associations between the patterns of use of different systemic hormonal contraceptives and the risk of venous thromboembolism during 2017–2019.Material and MethodsAll fertile‐aged women (15–49 years) living in Finland in 2017 and using hormonal contraception in 2017 and their 1:1 age‐ and residence‐matched controls not using hormonal contraception in 2017 (altogether 587 559 women) were selected from the Prescription Centre. All incident venous thromboembolism cases during 2018–2019 and their 4:1 age‐matched controls were further analyzed in a prospective nested case–control design to assess the associations between the use (starting, stopping, continuous vs no use) of different hormonal contraception types and venous thromboembolism.ResultsAltogether, 1334 venous thromboembolism cases occurred during the follow‐up period (incidence rate 1.14 per 1000 person‐years, 95% confidence interval [CI] 1.08–1.20), with an incidence rate ratio of hormonal contraception vs no hormonal contraception use of 1.42 (95% CI 1.27–1.58). Compared with non‐use, starting the use of gestodene and ethinylestradiol (adjusted odds ratio [aOR] 2.85; 95% CI 1.62–5.03), drospirenone and ethinylestradiol (aOR 1.55; 95% CI 0.98–2.44), desogestrel and ethinylestradiol (aOR 1.97; 95% CI 0.99–3.92), and transdermal patch releasing norelgestromin and ethinylestradiol (aOR 5.10; 95% CI 1.12–23.16), as well as continuing the use of gestodene and ethinylestradiol (aOR 2.60; 95% CI 1.61–4.21), drospirenone and ethinylestradiol (aOR 1.55; 95% CI 1.02–2.37), cyproterone‐acetate and estrogen/ethinylestradiol (aOR 1.66; 95% CI 1.06–2.61), and vaginal ring releasing etonogestrel and ethinylestradiol (aOR 3.27; 95% CI 1.95–5.48) were associated with venous thromboembolism risk. Regarding the type of estrogen, the highest risk was associated with current use (vs non use in the previous 180 days) of ethinylestradiol‐containing preparations (aOR 2.20; 95% CI 1.82–2.65), followed by estradiol‐containing preparations (aOR 1.39; 95% CI 1.04–1.87) with no risk for progestin‐only hormonal contraception. Current use of estradiol‐containing preparations was not associated with venous thromboembolism risk after exclusion of cyproterone‐acetate and estrogen/ethinylestradiol (aOR 1.05; 95% CI 0.66–1.66).ConclusionsAn increased risk of venous thromboembolism is associated with ethinylestradiol‐containing combined preparations. The use of estradiol‐containing combined preparations confers only a slightly increased risk, possibly driven by cyproterone‐containing combined oral contraceptives, whereas the use of progestin‐only contraception is not associated with venous thromboembolism.
Long‐term incidence of endometrial cancer after endometrial resection and ablation: A population based Swedish gynecologic cancer group (SweGCG) study
Authors: Flöter Rådestad Angelique , Dahm‐Kähler Pernilla , Holmberg Erik , Bjurberg Maria , Hellman Kristina , Högberg Thomas , Kjölhede Preben , Marcickiewicz Janusz , Rosenberg Per , Stålberg Karin , Åvall‐Lundqvist Elisabeth , Borgfeldt Christer 
Published: May 2022

AbstractIntroductionMinimally invasive methods to reduce menorrhagia were introduced in the 1980s and 1990s. Transcervical endometrial resection (TCRE) and endometrial ablation (EA) are two of the most frequently used methods. As none of them can guarantee a complete removal of the endometrium, there are concerns that the remaining endometrium may develop to endometrial cancer (EC) later in life. The primary aim was to analyze the long‐term incidence of EC after TCRE and EA in a nationwide population. The secondary aim was to assess the two treatment modalities separately.Material and MethodsThe Swedish National Patient Registry and National Quality Registry for Gynecological Surgery were used for identification of women who had TCRE or EA performed between 1997–2017. The cohort was followed from the first TCRE or EA until hysterectomy, diagnosis of EC, or death. Follow‐up data were retrieved from the National Cancer Registry and the National Death Registry. Expected incidence for EC in Swedish women was calculated using Swedish data retrieved from the NORDCAN project after having taken into account differences of age and follow‐up time. Cumulative incidence of EC after TCRE and EA, was calculated. A standardized incidence ratio was calculated based on the expected and observed incidence, stratified by age and year of diagnosis.ResultsIn total, 17 296 women (mean age 45.1 years) underwent TCRE (n = 8626) or EA (n = 8670). Excluded were 3121 who had a hysterectomy for benign causes during follow up. During a median follow‐up time of 7.1 years (interquartile range 3.1–13.3 years) the numbers of EC were 25 (0.3%) after TCRE and 2 (0.02%) after EA, respectively. The observed incidence was significantly lower than expected (population‐based estimate) after EA but not after TCRE, giving a standardized incidence ratio of 0.13 (95% confidence interval [CI] 0.03–0.53) after EA and 1.27 (95% CI 0.86–1.88) after TCRE. Median times to EC were 3.0 and 8.3 years after TCRE and EA, respectively.ConclusionsThere was a significant reduction of EC after EA, suggesting a protective effect, whereas endometrial resection showed an incidence within the expected rate.
Clinical and genetic findings in TRPM1‐related congenital stationary night blindness
Authors: Iosifidis Christos , Liu Jingshu , Gale Theodora , Ellingford Jamie M. , Campbell Christopher , Ingram Stuart , Chandler Kate , Parry Neil R. A. , Black Graeme C. , Sergouniotis Panagiotis I. 
Published: May 2022

ABSTRACTPurposeCongenital stationary night blindness (CSNB) is a heterogeneous group of Mendelian retinal disorders that present in childhood. Biallelic variants altering the protein‐coding region of the TRPM1 gene are one of the commonest causes of CSNB. Here, we report the clinical and genetic findings in 10 unrelated individuals with TRPM1‐retinopathy.MethodsStudy subjects were recruited through a tertiary clinical ophthalmic genetic service at Manchester, UK. All participants underwent visual electrodiagnostic testing and panel‐based genetic analysis.ResultsStudy subjects had a median age of 8 years (range: 3–20 years). All probands were myopic and had electroretinographic findings in keeping with complete CSNB. Notably, three probands reported no night vision problems. Fourteen different disease‐associated TRPM1 variants were detected. One individual was homozygous for the NM_001252024.2 (TRPM1):c.965 + 29G>A variant and a mini‐gene assay highlighted that this change results in mis‐splicing and premature protein termination. Additionally, two unrelated probands who had CSNB and mild neurodevelopmental abnormalities were found to carry a 15q13.3 microdeletion. This copy number variant encompasses seven genes, including TRPM1, and was encountered in the heterozygous state and in trans with a missense TRPM1 variant in each case.ConclusionOur findings highlight the importance of comprehensive genomic analysis, beyond the exons and protein‐coding regions of genes, for individuals with CSNB. When this characteristic retinal phenotype is accompanied by extraocular findings (including learning and/or behavioural difficulties), a 15q13.3 microdeletion should be suspected. Focused analysis (e.g. microarray testing) is recommended to look for large‐scale deletions encompassing TRPM1 in patients with CSNB and neurodevelopmental abnormalities.
Body shape and diet reflect arboreality degree of five congeneric snakes sympatric in the Atlantic forest
Authors: Banci Karina Rodrigues da Silva , Guimarães Murilo , Siqueira Lucas Henrique Carvalho , Muscat Edelcio , Sazima Ivan , Marques Otavio Augusto Vuolo 
Published: May 2022

AbstractThe substrate use by animals may influence both their morphology and diet. Species of the genus Chironius are among the most conspicuous frog‐eating, arboreal snakes in South America. The aim of the present study was to investigate whether diet and morphology relate to substrate use in five sympatric Chironius species from the Atlantic Forest. Our hypothesis is that habitat pressure is strong enough so that even closely related species will present differences. We collected morphological and diet data from specimens of C. bicarinatus, C. exoletus, C. foveatus, C. fuscus, and C. laevicollis housed in scientific collections. Information on habitat use were obtained by monitoring free‐ranging animals using thread‐bobbins and also from the literature. Our results demonstrate that C. foveatus is the most arboreal species, and C. laevicollis is the most terrestrial among the five studied species. Chironius foveatus is the slenderest, with one of the longest relative tail lengths, the narrowest ventral scales, the highest vertebral density, the largest eye diameter, green body color, and diet based on tree frogs (Hylidae). These traits indicate a higher arboreality for this species. On the other extreme, C. laevicollis is the stoutest species, and has the shortest tail, the largest head, the lowest vertebral density, and diet based on ground‐living frogs (Leptodactylidae). These traits indicate pronounced terrestriality for this species. The other three species have traits intermediate between the extremes showed by C. foveatus and C. laevicollis. We found evidence for a close relationship between arboreality or terrestriality, morphology, and diet.
Estrogen induces the expression of EBV lytic protein ZEBRA, a marker of poor prognosis in nasopharyngeal carcinoma
Authors: Dochi Hirotomo , Kondo Satoru , Murata Takayuki , Fukuyo Masaki , Nanbo Asuka , Wakae Kousho , Jiang Wen‐Ping , Hamabe‐Horiike Toshihide , Tanaka Mariko , Nishiuchi Takumi , Mizokami Harue , Moriyama‐Kita Makiko , Kobayashi Eiji , Hirai Nobuyuki , Komori Takeshi , Ueno Takayoshi , Nakanishi Yosuke , Hatano Miyako , Endo Kazuhira , Sugimoto Hisashi , Wakisaka Naohiro , Juang Shin‐Hun , Muramatsu Masamichi , Kaneda Atsushi , Yoshizaki Tomokazu 
Published: May 2022

AbstractSeveral epidemiological studies have suggested that Epstein–Barr virus (EBV) lytic infection is essential for the development of nasopharyngeal carcinoma (NPC), as the elevation of antibody titers against EBV lytic proteins is a common feature of NPC. Although ZEBRA protein is a key trigger for the initiation of lytic infection, whether its expression affects the prognosis and pathogenesis of NPC remains unclear. In this study, 64 NPC biopsy specimens were analyzed using immunohistochemistry. We found that ZEBRA was significantly associated with a worsening of progression‐free survival in NPC (adjusted hazard ratio, 3.58; 95% confidence interval, 1.08–11.87; p = 0.037). Moreover, ZEBRA expression positively correlated with key endocrinological proteins, estrogen receptor α, and aromatase. The transcriptional level of ZEBRA is activated by estrogen in an estrogen receptor α‐dependent manner, resulting in an increase in structural gene expression levels and extracellular virus DNA copy number in NPC cell lines, reminiscent of lytic infection. Interestingly, it did not suppress cellular proliferation or increase apoptosis, in contrast with cells treated with 12‐O‐tetradecanoylphorbol‐13‐acetate and sodium butyrate, indicating that viral production induced by estrogen is not a cell lytic phenomenon. Our results suggest that intratumoral estrogen overproduced by aromatase could induce ZEBRA expression and EBV reactivation, contributing to the progression of NPC.
Analysis of microbiome in gastrointestinal stromal tumors: Looking for different players in tumorigenesis and novel therapeutic options
Authors: Ravegnini Gloria , Fosso Bruno , Ricci Riccardo , Gorini Francesca , Turroni Silvia , Serrano Cesar , Pilco‐Janeta Daniel F. , Zhang Qianqian , Zanotti Federica , De Robertis Mariangela , Nannini Margherita , Pantaleo Maria Abbondanza , Hrelia Patrizia , Angelini Sabrina 
Published: May 2022

AbstractPreclinical forms of gastrointestinal stromal tumor (GIST), small asymptomatic lesions, called microGIST, are detected in approximately 30% of the general population. Gastrointestinal stromal tumor driver mutation can be already detected in microGISTs, even if they do not progress into malignant cancer; these mutations are necessary, but insufficient events to foster tumor progression. Here we profiled the tissue microbiota of 60 gastrointestinal specimens in three different patient cohorts—micro, low‐risk, and high‐risk or metastatic GIST—exploring the compositional structure, predicted function, and microbial networks, with the aim of providing a complete overview of microbial ecology in GIST and its preclinical form. Comparing microGISTs and GISTs, both weighted and unweighted UniFrac and Bray–Curtis dissimilarities showed significant community‐level separation between them and a pronounced difference in Proteobacteria, Firmicutes, and Bacteroidota was observed. Through the LEfSe tool, potential microbial biomarkers associated with a specific type of lesion were identified. In particular, GIST samples were significantly enriched in the phylum Proteobacteria compared to microGISTs. Several pathways involved in sugar metabolism were also highlighted in GISTs; this was expected as cancer usually displays high aerobic glycolysis in place of oxidative phosphorylation and rise of glucose flux to promote anabolic request. Our results highlight that specific differences do exist in the tissue microbiome community between GIST and benign lesions and that microbiome restructuration can drive the carcinogenesis process.
Tisotumab vedotin in Japanese patients with recurrent/metastatic cervical cancer: Results from the innovaTV 206 study
Authors: Yonemori Kan , Kuboki Yasutoshi , Hasegawa Kosei , Iwata Takashi , Kato Hidenori , Takehara Kazuhiro , Hirashima Yasuyuki , Kato Hisamori , Passey Chaitali , Buchbjerg Jeppe Klint , Harris Jeffrey R. , Andreassen Camilla Mondrup , Nicacio Leonardo , Soumaoro Ibrahima , Fujiwara Keiichi 
Published: May 2022

AbstractNew treatments, particularly second‐line options, are needed to improve outcomes for patients with recurrent/metastatic cervical cancer (r/mCC). Tisotumab vedotin (TV) is an antibody–drug conjugate directed to tissue factor, a transmembrane protein commonly expressed in cancer cells, to deliver cytotoxic monomethyl auristatin E. This single‐arm, open‐label phase 1/2 trial evaluated the consistency of safety and efficacy outcomes of TV in Japanese patients with r/mCC to bridge the current findings with those reported in previous trials in non‐Japanese patients in the United States and Europe. In part 1 (dose escalation; N = 6), patients with advanced solid tumors received TV 1.5 or 2.0 mg/kg once every 3 weeks to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D). Part 2 (dose expansion; N = 17) evaluated the RP2D in r/mCC patients with 1–2 prior lines of therapy. In part 1, no dose‐limiting toxicities were observed, the MTD was not reached, and TV 2.0 mg/kg was established as the RP2D. In part 2, the most common treatment‐emergent adverse events were anemia (58.8%), nausea (58.8%), alopecia (47.1%), epistaxis (47.1%), and diarrhea (35.3%); adverse events of special interest were bleeding (76.5%), ocular events (35.3%), and peripheral neuropathy (17.6%), and were mostly grade 1/2. In part 2, confirmed objective response rate was 29.4%, median duration of response was 7.1 months, and median time to response was 1.2 months. In Japanese patients with r/mCC, TV demonstrated a manageable and tolerable safety, pharmacokinetics, and efficacy profile consistent with that observed in non‐Japanese patients.
Prosaposin, tumor‐secreted protein, promotes pancreatic cancer progression by decreasing tumor‐infiltrating lymphocytes
Authors: Miyahara Yoji , Takano Shigetsugu , Sogawa Kazuyuki , Tomizawa Satoshi , Furukawa Katsunori , Takayashiki Tsukasa , Kuboki Satoshi , Ohtsuka Masayuki 
Published: May 2022

AbstractGlycoproteins produced by tumor cells are involved in cancer progression, metastasis, and the immune response, and serve as possible therapeutic targets. Considering the dismal outcomes of pancreatic ductal adenocarcinoma (PDAC) due to its unique tumor microenvironment, which is characterized by low antitumor T‐cell infiltration, we hypothesized that tumor‐derived glycoproteins may serve as regulating the tumor microenvironment. We used glycoproteomics with tandem mass tag labeling to investigate the culture media of three human PDAC cell lines, and attempted to identify the key secreted proteins from PDAC cells. Among the identified glycoproteins, prosaposin (PSAP) was investigated for its functional contribution to PDAC progression. PSAP is highly expressed in various PDAC cell lines; however, knockdown of intrinsic PSAP expression did not affect the proliferation and migration capacities. Based on the immunohistochemistry of resected human PDAC tissues, high PSAP expression was associated with poor prognosis in patients with PDAC. Notably, tumors with high PSAP expression showed significantly lower CD8+ T‐cell infiltration than those with low PSAP expression. Furthermore, PSAP stimulation decreased the proportion of CD8+ T cells in peripheral blood monocytes. Finally, in an orthotopic transplantation model, the number of CD8+ T cells in the PSAP shRNA groups was significantly increased, resulting in a decreased tumor volume compared with that in the control shRNA group. PSAP suppresses CD8+ T‐cell infiltration, leading to the promotion of PDAC progression. However, further studies are warranted to determine whether this study contributes to the development of a novel immunomodulating therapy for PDAC.
Bitten by the travelling bug: a review of toponymous contributions in dermatology
Authors: Sil Abheek , Gandhi Suneil , Das Anupam 
Published: May 2022

Abstract
The diverse world of dermatology has a wealth of protracted and at times tenuous names encompassing disease conditions, characteristic clinical descriptions and signs, among others. Many dermatological entities are identified by toponyms or place names. Although some sound irrelevant and archaic (with only historical importance reminding us of the lively history of the subject), other terminologies aid in easy recollection. In this review, we have succinctly summarized various toponymous description in dermatology covering diseases, signs, scales, criteria and treatments.
Eruptive naevi associated with encorafenib for metastatic colorectal cancer: two cases
Authors: Alfallouji Yasmin , Spencer Ashley , Calonje Eduardo , Perrett Conal M. , Watchorn Richard , Borysiewicz Catherine , Hodgkinson Tara , Wasan Harpreet , Bunker Christopher B. , Sidwell Rachel U. 
Published: May 2022

Abstract
Encorafenib is a BRAF inhibitor increasingly used as a second-line treatment for metastatic melanoma and colorectal cancer. BRAF inhibitors have been reported to be associated with new and changing melanocytic lesions, including eruptive naevi. We describe two cases of eruptive naevi secondary to encorafenib used for the treatment of BRAF-mutant metastatic colorectal cancer.