bluuebunny/crossref_metadata_2025_split huggingface dataset:
The future of artificial intelligence in the context of industrial ecology
Authors: Donati Franco , Dente Sébastien M. R. , Li Chen , Vilaysouk Xaysackda , Froemelt Andreas , Nishant Rohit , Liu Gang , Tukker Arnold , Hashimoto Seiji 
Published: July 2022

AbstractArtificial intelligence (AI) applications and digital technologies (DTs) are increasingly present in the daily lives of citizens, in cities and in industries. These developments generate large amounts of data and enhance analytical capabilities that could benefit the industrial ecology (IE) community and sustainability research in general. With this communication, we would like to address some of the opportunities, challenges, and next steps that could be undertaken by the industrial ecology community in this realm. This article is an adapted summary of the discussion held by experts in industrial ecology, AI, and sustainability during the 2021 Industrial Ecology Day conference session titled “The Future of Artificial Intelligence in the Context of Industrial Ecology.” In brief, building on previous studies and communications, we advise the industrial ecology community to: (1) create internal committees and working groups to monitor and coordinate AI applications within and outside the community; (2) promote and ensure transdisciplinary efforts; (3) determine optimal infrastructure and governance of AI for IE to minimize undesired effects; and (4) act on effective representation and on reduction of digital divides.
Ultrasonographic measurement of vaginal thickness: Relation to menopausal status and genitourinary syndrome of menopause
Authors: Türk Sema , Ertürk Coşkun Ayşe D. , Vural Fisun 
Published: July 2022

AbstractObjectiveTo compare the total vaginal wall thickness (TVT) and total mucosal thickness (TMT) measurements of premenopausal and postmenopausal women measured by ultrasonography and to determine the association of these measurements to findings and symptoms of genitourinary syndrome of menopauseMethodsHealthy volunteers, 80 postmenopausal and 80 premenopausal, were included. Ultrasonographic TVT and TMT measurements, vaginal health index (VHI) scores and pH values were recorded. The daily impact of vaginal aging (DIVA) scale was administered to women in the postmenopausal group.ResultsTVT measurements of the postmenopausal group (6.55 ± 2.00 mm) were lower than the premenopausal group (10.37 ± 2.11 mm) (p: 0.000). TMT measurements of the postmenopausal group (1.46 ± 0.50 mm) were lower than the premenopausal group (2.19 ± 0.60 mm) (p: 0.000). The VHI scores of the postmenopausal group were significantly lower than the premenopausal group, the pH value was higher (p < 0.05). Considering all women TVT and TMT measurements were inversely correlated with pH values and positively correlated with total VHI scores. There was no significant correlation between any component scores of the DIVA scale and TVT, TMT, pH, and VHI total (p > 0.05).ConclusionsTVT and TMT measurements in postmenopausal women are significantly lower than premenopausal women. Examination findings and thickness measurements are correlated. Transabdominal ultrasonography is a method that can be used in the evaluation of vaginal thickness which is not painful for the patient, is easy to apply and gives results consistent with the examination findings. However, measurements and examination findings do not correlate with the DIVA scores in postmenopausal women.
Pharmacokinetics and anti‐nausea effects of intravenous ondansetron in hospitalized dogs exhibiting clinical signs of nausea
Authors: Sotelo Cindy K. , Shropshire Sarah B. , Quimby Jessica , Simpson Sydney , Gustafson Daniel L. , Zersen Kristin M. 
Published: July 2022

AbstractThe purpose of this study was to evaluate the pharmacokinetics of intravenous (IV) ondansetron in a population of hospitalized dogs exhibiting clinical signs of nausea. The causes of nausea included pancreatitis, gastroenteritis, endocarditis, chemotherapy‐induced nausea, diabetes mellitus and ketoacidosis, acute kidney injury with aspiration pneumonia, pyometra, uroabdomen, neoplasia, and hepatopathy. Twenty‐four dogs were randomly assigned to one of the following IV ondansetron protocols: 1 mg/kg q12h, 0.5 mg/kg q12h, 1 mg/kg q8h, 0.5 mg/kg q8h. Serum was collected at 0, 0.25, 0.5, 1, 2, 4, 8, 16, and 24 h after the first dose, and nausea scores were recorded at multiple time points. Ondansetron and arginine vasopressin (AVP) concentrations were measured via high‐performance liquid chromatography coupled to tandem mass spectrometry and ELISA, respectively. Noncompartmental pharmacokinetic modeling and dose interval modeling were performed. Ondansetron displayed linear pharmacokinetics. In the 0.5 mg/kg group, mean Cmax = 214 ng/ml, AUC0–8h = 463 ng/ml*h, and calculated half‐life was 1.9 h. In the 1 mg/kg group, mean Cmax = 541 ng/ml, AUC0–8h = 1057 ng/ml*h and calculated half‐life was 1.6 h. Serum ondansetron concentrations were not significantly different between dogs that required rescue anti‐nausea medication (non‐responders) and dogs that did not require rescue therapy (responders). In total, 83.3% of patients in the 0.5 mg/kg q8h, 0.5 mg/kg q12h, and 1 mg/kg q8h groups had improvement in nausea scores. In total, 66.7% of patients in the 1 mg/kg q12h group had improvement in nausea scores. In total, 33% of patients had resolution of nausea in the 0.5 mg/kg q8h, 1 mg/kg q8h, and 1 mg/kg q12h groups, and 16% of patients had resolution of nausea in the 0.5 mg/kg q12h group. AVP concentrations were highly variable and did not correlate with nausea scores. Nausea scores significantly decreased regardless of dosage protocol. AVP was not a reliable biomarker of nausea in this group of dogs.
The role of macrophage TAM receptor family in the acute‐to‐chronic progression of liver disease: From friend to foe?
Authors: Huang Haitao , Jiang Jingyu , Chen Ruihan , Lin Yimou , Chen Hui , Ling Qi 
Published: July 2022

AbstractHepatic macrophages, the key cellular components of the liver, emerge as essential players in liver inflammation, tissue repair and subsequent fibrosis, as well as tumorigenesis. Recently, the TAM receptor tyrosine kinase family, consisting of Tyro3, Axl and MerTK, was found to be a pivotal modulator of macrophages. Activation of macrophage TAM receptor signalling promotes the efferocytosis of apoptotic cells and skews the polarization of macrophages. After briefly reviewing the mechanisms of TAM receptor signalling in macrophage polarization, we focus on their role in liver diseases from acute injury to chronic inflammation, fibrosis and then to tumorigenesis. Notably, macrophage TAM receptor signalling seems to be a two‐edged sword for liver diseases. On one hand, the activation of TAM receptor signalling inhibits inflammation and facilitates tissue repair during acute liver injury. On the other hand, continuous activation of the signalling contributes to the process of chronic inflammation into fibrosis and tumorigenesis by evoking hepatic stellate cells and inhibiting anti‐tumour immunity. Therefore, targeting macrophage TAM receptors and clarifying its downstream pathways will be exciting prospects for the precaution and treatment of liver diseases, particularly at different stages or statuses.
Efficacy of anti‐fungal agents for invasive fungal infection prophylaxis in liver transplant recipients: A network meta‐analysis
Authors: Liu Yusi , Lan Chunhai , Qin Sibei , Qin Zhuo , Zhang Zhiqiang , Zhang Peng , Cao Weiling 
Published: July 2022

AbstractAt present, there is still a lack of effective invasive fungal prophylaxis therapy in liver transplant recipients (LTRs). This study aimed to analysis the latest evidence on efficacy of current prophylactic anti‐fungal therapy, and systematically compare between anti‐fungal agents and placebo by a fixed‐effects meta‐analysis in all randomised controlled trials. A network meta‐analysis was performed for invasive fungal infection (IFI) among different agents in 14 randomised controlled trials, in which 10 anti‐fungal approaches were identified. Overall, anti‐fungal prophylaxis reduced the rate of IFI (RR 0.30, 95% CI 0.18–0.52) and proven IFI (RR 0.27, 95% CI 0.14–0.53) when compared to placebo. In the network meta‐analysis, an equivalent reduction in the rate of IFI was observed in fluconazole (OR 4.70, 95% CI 1.22–18.10), itraconazole (OR 5.82, 95% CI 1.10–30.71) and Liposomal amphotericin B (LAmB, OR 5.74, 95% CI 1.29–25.58) groups when compared with placebo. Anidulafungin might be the most effective agents in IFI prevention; however, this superiority did not meet statistically significance. Our study indicated that fluconazole, echinocandins and LAmB are equivalent in efficacy. Of which, fluconazole is recommended for the prevention of IFI in LTRs due to its efficacy, economics and compliance.
A novel SREBF1::NACC1 gene fusion in an unclassifiable intracranial tumour
Authors: Takeuchi Yasuhide , Mineharu Yohei , Arakawa Yoshiki , Hara Masayuki , Oichi Yuki , Kamata Takahiko , Fukuyama Keita , Yamamoto Yoshihiro , Yamanaka Toshiyuki , Kakiuchi Nobuyuki , Hiratomo Emi , Hirata Masahiro , Yokoo Hideaki , Hirose Takanori , Minamiguchi Sachiko , Ogawa Seishi , Muto Manabu , Miyamoto Susumu , Haga Hironori 
Published: July 2022

AbstractA 39‐year‐old man had an intracranial tumour without infiltration into the surrounding cerebral tissue. The tumour recurred seven times in 11 years but maintained a well‐demarcated character. Histopathological examination of the 4th surgical specimens showed nests of tumour cells surrounding small blood vessels. The tumour cells harboured amphophilic cytoplasm and small round nuclei with fine chromatin, and perinuclear haloes and clear borders were frequently observed, which was unclassifiable histology. By the Deutsches Krebsforschungszentrum methylation classifier, the tumour was not classified into any of the methylation classes. mRNA sequencing identified a novel SREBF1::NACC1 gene fusion. This intracranial tumour could be a novel tumour entity with NACC1 rearrangement showing characteristic histological and diagnostic imaging findings.
Atrial myxoma surgery and P‐wave remodeling
Authors: Herrera Cristian , Bruña Vanesa , Barrio Jose María , Cuerpo Gregorio , Fernández‐Avilés Francisco , Bayés de Luna Antonio , Martínez‐Sellés Manuel 
Published: July 2022

AbstractIntroductionData regarding atrial electrocardiographic parameters in patients with atrial myxomas are scarce.MethodsWe aimed to study atrial electrocardiographic features in patients with atrial myxomas, before and after surgery. We also analyze the incidence of atrial fibrillation during follow‐up and its correlation with different P‐wave indexes. In total 32 patients in sinus rhythm that underwent atrial myxoma surgery were included.ResultsMean age was 55.0 ± 12.6 years and 18 (56.3%) were women. Ten patients had left atrial enlargement (31.3%). Only one myxoma was located in the right atrium. At baseline seven cases of partial interatrial block (IAB) were detected (21.9%), two in the absence of left atrial enlargement. There were significant differences in atrial electrocardiographic indexes before and after surgery, including P‐wave duration (108.9 ± 17.9 ms vs. 93.0 ± 12.4 ms; p < .001), partial IAB (21.9% vs. 3.1%; p = .012) and duration of P‐wave terminal force in lead V1 negativity (−0.6 ± 0.3 vs. −0.5 ± 0.3 mm; p = .034). At a mean follow‐up of 10.0 ± 5.5 years, 10 patients (31.3%) had experienced at least one episode of atrial fibrillation. Post‐operative P‐wave duration was associated with atrial fibrillation occurrence during follow‐up (Hazard ratio: 0.90, 95% confidence interval: 0.83–0.98; p = .020).ConclusionsAbnormalities in atrial electrocardiographic indexes are common in atrial myxomas and frequently improve after surgery. Post‐operative P‐wave duration is associated with atrial fibrillation occurrence during follow‐up.
How does religion affect health in the gold mining industry? Evidence from Nigeria
Authors: Wang Dongqin 
Published: July 2022

AbstractThis study investigates the interaction effects of the environmental factors of mining and religion on health. Using data from the Demographic and Health Survey and gold mine geolocation data in Nigeria, the difference‐in‐differences estimation reveals that artisanal and small‐scale gold mining in Nigeria has an adverse health effect on Muslim women's fertility. In particular, living near gold mines increases Muslim women's (i.e., the treated group) probability of infecundity or premature menopause by about 12 percentage points compared to Christian women (i.e., the untreated group), and the effects are stronger in northern Nigeria than in southern Nigeria. By eliminating other possible channels, the results show that the main mechanism appears to be Muslim women being more likely to work in gold mines in their family compounds. The results are robust to the alternative distance cutoffs, other measures of health outcomes, and triple‐difference approach. Understanding the impact of religion on the health of women in the mining industry may help effectively reduce infertility in developing countries.
Robust Correspondence Analysis
Authors: Riani Marco , Atkinson Anthony C. , Torti Francesca , Corbellini Aldo 
Published: July 2022

AbstractCorrespondence analysis is a method for the visual display of information from two-way contingency tables. We introduce a robust form of correspondence analysis based on minimum covariance determinant estimation. This leads to the systematic deletion of outlying rows of the table and to plots of greatly increased informativeness. Our examples are trade flows of clothes and consumer evaluations of the perceived properties of cars. The robust method requires that a specified proportion of the data be used in fitting. To accommodate this requirement we provide an algorithm that uses a subset of complete rows and one row partially, both sets of rows being chosen robustly. We prove the convergence of this algorithm.
Examining associations between suicidal desire, implicit fearlessness about death, and lifetime frequency of suicide attempts
Authors: Tull Matthew T. , DeMoss Zachary T. , Anestis Michael D. , Lavender Jason M. , McDermott Michael J. , Gratz Kim L. 
Published: July 2022

AbstractIntroductionSuicide models propose that the capability for suicide, such as fearlessness about death (FAD), is necessary for the transition from suicidal desire to a suicide attempt. Most studies have relied on self‐report methods to assess FAD. However, this research has produced equivocal results. As individuals may have limited awareness of learned or pre‐existing associations between fearlessness and death, implicit measures of FAD hold promise. This study used a novel implicit association test (IAT), the IAT‐FAD, to examine associations between suicidal desire, implicit FAD, and lifetime suicide attempt frequency.MethodsPatients in residential substance use treatment (N = 75), a population with increased suicide risk and exposure to painful and provocative events, completed the IAT‐FAD and assessments of suicidal desire and past suicide attempts.ResultsImplicit FAD moderated the association between suicidal desire and lifetime frequency of suicide attempts associated with an intent to die and requiring medical attention (although not ambivalent suicide attempts). Suicidal desire related to medically attended suicide attempts only at high implicit FAD levels, and to suicide attempts with a clear intent to die only at high or mean implicit FAD levels.ConclusionResults provide initial support for the relevance of implicit measures of FAD for understanding suicide risk.
Distribution of active tectonics in the Himalayan piedmont (Darjeeling, eastern India) inferred from Horizontal‐to‐Vertical spectral ratio analysis of passive seismic records
Authors: Large E. , Huyghe Pascale , Mugnier J‐L. , Guillier B. , Taral S. , Gyawali B.R. , Chabraborty T. 
Published: July 2022

AbstractThe pattern of active deformation of frontal structures in Darjeeling Himalaya is complex with out‐of‐sequence reactivations in the chain and development of scarps associated with earthquake ruptures reaching the surface in the piedmont. To clarify the distribution of active deformation in this area, we analyse passive seismic records by the Horizontal‐to‐Vertical Spectral Ratio method along three NS trending profiles. We image the Siwalik sedimentary rocks / recent deposits interface under the piedmont and show folded and faulted geometries. Two of these faults are located under scarps of about 10 m affecting the 3.7 ± 0.7 ka old surface of the Tista megafan. Such features imply that about half of the convergence is expressed south of the Himalayan front while the other part occurs out‐of‐sequence in the chain, suggesting a very limited activity of the Main Frontal Thrust itself.
A Mathematical Model of Maladaptive Inward Eutrophic Remodeling of Muscular Arteries in Hypertension
Authors: Rachev Alexander , Shazly Tarek 
Published: July 2022

Abstract
We propose a relatively simple two-dimensional mathematical model for maladaptive inward remodeling of resistive arteries in hypertension in terms of vascular solid mechanics. The main premises are: (i) maladaptive inward remodeling manifests as a reduced increase in the arterial mass compared to the case of adaptive remodeling under equivalent hypertensive pressures and (ii) the pressure-induced circumferential stress in the arterial wall is restored to its basal target value as happens in the case of adaptive remodeling. The rationale for these assumptions is the experimental findings that elevated tone in association with sustained hypertensive pressure down-regulate the normal differentiation of vascular smooth muscle cells from contractile to synthetic phenotype and the data for the calculated hoop stress before and after completion of remodeling. Results from illustrative simulations show that as the hypertensive pressure increases, remodeling causes a nonmonotonic variation of arterial mass, a decrease in inner arterial diameter, and an increase in wall thickness. These findings and the model prediction that inward eutrophic remodeling is preceded by inward hypertrophic remodeling are supported by published observations. Limitations and perspectives for refining the mathematical model are discussed.
Early-onset neonatal sepsis in the Paris area: a population-based surveillance study from 2019 to 2021
Authors: Sikias Paola , Biran Valérie , Foix-L'Hélias Laurence , Plainvert Céline , Boileau Pascal , Bonacorsi Stéphane 
Published: July 2022

BackgroundEarly-onset neonatal sepsis (EOS) is a rare condition but an important cause of severe morbidity and mortality in neonates.MethodsThis is a prospective observational study in neonates born at ≥34 weeks of gestation (WG). The primary endpoint was EOS, defined by isolation of pathogenic species from blood culture and/or cerebrospinal fluid culture within 72 hours after birth. Data on EOS were collected exhaustively from all maternity wards in Paris area (April 2019–March 2021).Results108 EOS were recorded (annual incidence, 0.32 per 1000 live births; 95% CI 0.26 to 0.38). In term infants, the most frequent pathogens were group BStreptococcus(GBS) (n=47) andEscherichia coli(n=20); in late preterm infants, the most frequent pathogens wereE. coli(n=15) and GBS (n=7). Fifteen meningitis cases were diagnosed. FiveE. colistrains (14%) were resistant to both amoxicillin and gentamicin, which is an empiric treatment for EOS. Of the 54 infants with GBS infections, 35 were born from mothers with negative GBS prepartum screening test and 8 from mothers with no screening. Two deaths were reported, both in term infants (Proteus mirabilisandE. coli).ConclusionIn neonates ≥34 WG born in the Paris area, GBS was twice as frequent asE. coliin term infants. EOS was six times more frequent in late preterm than in term infants and was due toE. coliin 60% of cases. Prevention of GBS EOS and empiric antibiotic treatment of EOS could be improved.
Rate of invasive bacterial infection in recently vaccinated young infants with fever without source
Authors: Barreiro-Parrado Ana , Lopez Eider , Gomez Borja , Lejarzegi Ainara , Fernandez-Uria Amaia , Benito Javier , Mintegi Santiago 
Published: July 2022

ObjectiveTo compare the rates of invasive bacterial infection (IBI) (bacterial pathogen in blood or cerebrospinal fluid) and urinary tract infection (UTI) in febrile infants between 42 and 90 days of age who had and had not been vaccinated in the previous 48 hours.DesignObservational study; secondary analysis of a prospective registry-based cohort study.SettingPaediatric emergency department.PatientsInfants 42–90 days of age with fever without source seen between 2010 and 2021.Main outcome measuresRates of IBI (bacterial pathogen in blood or cerebrospinal fluid) and UTI (urine culture obtained by an aseptic method yielding growth of ≥10 000 cfu/mL with associated leucocyturia).ResultsWe included 1522 infants, including 185 (12.2%) vaccinated in the previous 48 hours. Overall, 19 (1.25%) were diagnosed with an IBI and 282 (18.5%) with a UTI. No recently immunised infants were diagnosed with an IBI (vs 19, 1.4% of those not recently immunised, p=0.2). The UTI rate was higher in infants not recently immunised (20.1% vs 7.0%, p<0.01; OR: 3.3 (1.9–5.9)).ConclusionsAlthough the rate of UTI in recently immunised infants 42–90 days old with fever without a source is lower than in those not recently immunised, recommending screening for UTI seems appropriate. If the lower rate of IBI among recently immunised well-appearing infants is confirmed, the recommendation to systematically perform blood tests in these infants should be reconsidered.
Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma
Authors: Kernohan Ashleigh , Homer Tara , Shabaninejad Hosein , King Anthony J , Hudson Jemma , Fernie Gordon , Azuara-Blanco Augusto , Burr Jennifer , Sparrow John M , Garway-Heath David , Barton Keith , Norrie John , Maclennan Graeme , Vale Luke 
Published: July 2022

SynopsisAdvanced glaucoma is associated with sight loss. This within-trial economic evaluation compares medical and surgical management strategies. At 2 years, medication appears more cost-effective though longitudinal outcomes are an important subject in future research.Background/aimsOpen angle glaucoma (OAG) is a progressive optic neuropathy. Approximately 25% of newly diagnosed patients with OAG present with advanced disease in at least one eye. The vision loss associated with OAG can lead to significant impacts on vision, quality of life and health care resources. The Treatment of Advanced Glaucoma Study is a randomised controlled trial comparing the effectiveness of primary surgical and medical management for newly diagnosed advanced patients with OAG. An economic evaluation was carried out to understand the costs and benefits of each strategy.MethodsA cost utility analysis was carried out from a National Health Service perspective over a 2-year time horizon inclusive of patient costs. The primary outcome was patient health-related quality of life measured by the EQ-5D-5L, Health Utilities Index 3 (HUI3) and Glaucoma Utility Index (GUI). Results were expressed as incremental cost per QALY gained.ResultsTrabeculectomy was associated with higher costs and greater effect, the EQ-5D-5L results have an incremental cost per QALY of £45,456. The likelihood of surgery being cost-effective at a £20, 000, £30,000 and £50,000 QALY threshold is 0%, 12% and 56%, respectively. The results for the HUI3, GUI and inclusion of patient costs do not change the conclusions of the study.ConclusionThis is the first study to evaluate management strategies for those presenting with advanced glaucoma. At a 2-year time horizon, medication is the more cost-effective approach for managing glaucoma. Future research can focus on the costs and benefits of the treatments over a longer time horizon.