bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generalized variational inequalities for linguistic interpretations using intuitionistic fuzzy relations and projected dynamical systems
Authors: Xie Ting , Li Dapeng 
Published: April 2022

AbstractThe fuzzy set theory enables us to represent our knowledge under multiple interpretations and axiomatic foundations from linguistic to computational representations. While the intuitionistic fuzzy set, as a generalization of the fuzzy set, cannot only represent the tolerance levels, but also the intolerance levels which a decision maker can tolerate and cannot tolerate in the accomplishment of a linguistic interpretation, in this paper, we introduce the generalized variational inequalities for linguistic interpretations using intuitionistic fuzzy relations. It is shown that such problems can be transformed into the classical (nonfuzzy) generalized variational inequalities by means of level sets of the intuitionistic fuzzy relation. Furthermore, the equivalence between the generalized variational inequalities with intuitionistic fuzzy relations and the fuzzy fixed point problems is established. Finally, based on the projection method, we propose an iterative algorithm and a projected neural network model for the generalized variational inequalities with intuitionistic fuzzy relations, and the stability of the proposed projected dynamical system is also investigated.
The impact of the COVID-19 pandemic on pediatric developmental services: a cross-sectional study on overall burden and mental health status
Authors: Borusiak Peter , Mazheika Yuliya , Bauer Susanne , Haberlandt Edda , Krois Ilona , Fricke Christian , Simon Liane , Beschoner Petra , Jerg-Bretzke Lucia , Geiser Franziska , Hiebel Nina , Weidner Kerstin , Albus Christian , Morawa Eva , Erim Yesim 
Published: April 2022

Abstract
Background
The COVID-19 outbreak has taken a heavy toll on the mental well-being of healthcare workers, even those who have not been directly involved in the care of acutely ill patients. The aims of this study were to identify the overall burden and mental health status of healthcare workers in pediatric developmental services under the influence of the COVID-19 pandemic, and to identify the risk and protective factors associated with mental health.

Methods
This cross-sectional web-based study was part of a large multicenter VOICE study conducted among employees ((neuro-)pediatricians, psychologists, speech therapists, occupational therapists, etc.) from various pediatric developmental services between June and July 2020. A total of 1291 questionnaires regarding overall burden, mental health status (depression, generalized anxiety disorder and emotional exhaustion) and risk and protective factors for mental health (working conditions, potential problems during the COVID-19 pandemic and psychological resources) were analyzed. Descriptive statistics and multiple linear regression were used for data analysis.

Results
A total of 44.5% (574/1291) participants felt a high or very high overall burden during the COVID-19 pandemic. Of all the participants, 14.6% (171/1173) reported clinically significant levels of depressive symptoms, 17.0% (199/1173) reported generalized anxiety disorder symptoms and 44.6% (532/1192) reported emotional exhaustion. Multiple linear regression analyses identified several common risk and protective factors for mental health status variables. The burden of an increase in the quantity of work, fear of work and fear of becoming infected showed the strongest negative associations, whereas psychological resources and sufficient relaxation in leisure time exhibited the strongest positive associations.

Conclusion
Employees who were not directly involved in the care of acutely ill patients were also exposed to considerable stress, some of which was not different from that experienced by professionals who were directly affected. These employees should not be lost sight of and must be offered appropriate support.
Genetic heterogeneity on sleep disorders in Parkinson’s disease: a systematic review and meta-analysis
Authors: Huang Jingxuan , Cheng Yangfan , Li Chunyu , Shang Huifang 
Published: April 2022

AbstractA growing amount of evidence has indicated contributions of variants in causative genes of Parkinson’s disease (PD) to the development of sleep disturbance in PD and prodromal PD stages. In this article, we aimed to investigate the role of genetics in sleep disorders in PD patients and asymptomatic carriers at prodromal stage of PD. A systematic review and meta-analysis of observational studies was conducted based on the MEDLINE, EMBASE and PsychINFO databases. A pooled effect size was calculated by odds ratio (OR) and standard mean difference (SMD). Forty studies were selected for quantitative analysis, including 17 studies on glucocerebrosidase (GBA), 25 studies on Leucine-rich repeat kinase 2 (LRRK2) and 7 on parkin (PRKN) genes, and 3 studies on alpha-synuclein gene (SNCA) were used for qualitative analysis. Patients with PD carrying GBA variants had a significantly higher risk for rapid-eye-movement behavior disorders (RBD) (OR, 1.82) and higher RBD Screening Questionnaire scores (SMD, 0.33). Asymptomatic carriers of GBA variants had higher severity of RBD during follow-up. Patients with PD carrying the LRRK2 G2019S variant had lower risk and severity of RBD compared with those without LRRK2 G2019S. Variants of GBA, LRRK2 and PRKN did not increase or decrease the risk and severity of excessive daytime sleepiness and restless legs syndrome in PD. Our findings suggest that the genetic heterogeneity plays a role in the development of sleep disorders, mainly RBD, in PD and the prodromal stage of PD.
α-Synuclein arginylation in the human brain
Authors: Zhao Jun , Pan Buyan , Fina Marie , Huang Yun , Shimogawa Marie , Luk Kelvin C. , Rhoades Elizabeth , Petersson E. James , Dong Dawei W. , Kashina Anna 
Published: April 2022

Abstract
Background
Alpha-synuclein (α-syn) exhibits pathological misfolding in many human neurodegenerative disorders. We previously showed that α-syn is arginylated in the mouse brain and that lack of arginylation leads to neurodegeneration in mice.

Methods
Here, we tested α-syn arginylation in human brain pathology using newly derived antibodies in combination with Western blotting, biochemical assays, and experiments in live neurons.

Results
We found that α-syn was arginylated in the human brain on E46 and E83, two sites previously implicated in α-syn pathology and familial cases of Parkinson’s disease. The levels of arginylation in different brain samples ranged between ~ 3% and ~ 50% of the total α-syn pool, and this arginylation nearly exclusively concentrated in the subcellular α-syn fraction that sedimented at low centrifugation speeds and appeared to be simultaneously targeted by multiple posttranslational modifications. Arginylated α-syn was less susceptible to S129 phosphorylation and pathological aggregation in neurons. The arginylation level inversely correlated with the overall α-syn levels and with patient age, suggesting a possible causal relationship between arginylation decline and α-syn-dependent neuropathology.

Conclusion
We propose that α-syn arginylation constitutes a potential neuroprotective mechanism that prevents its abnormal accumulation during neurodegeneration and aging in the human brain.
The clinical characteristics and prognosis in adult Ph negative acute lymphoblastic leukemia with TP53 aberrations
Authors: Fang Qiuyun , Gong Xiaoyuan , Liu Kaiqi , Jia Yujiao , Song Yang , Zhang Guangji , Li Yan , Hao Qishan , Ma Yueshen , Wei Shuning , Liu Bingcheng , Wang Ying , Wei Hui , Wang Jianxiang , Mi Yingchang 
Published: April 2022

AbstractVery few reports elucidate the prognosis of patients with TP53 aberrations using both measurable residual disease (MRD) and the status of having undergone allogeneic hematopoietic stem cell transplantation (allo-SCT). In this study, aberrations of TP53 were analyzed using next-generation sequencing (NGS) and fluorescence in situ hybridization (FISH) in patients with Philadelphia chromosome-negative (Ph−) ALL enrolled in a prospective single-arm clinical trial at our leukemia center. We analyzed the survival of the patients grouped according to the MRD level at the third month and whether or not received allo-SCT. We found that allo-SCT could improve the OS in patients with TP53 aberrations; Patients having negative MRD at the third month still showed worse 3-year OS and 3-year DFS without undergoing allo-SCT, which is different from previous studies, moreover, the prognostic significance of TP53 deletions was as important as TP53 mutations, the importance of screening both TP53 deletions and mutations in adult Ph− ALL at diagnosis should be emphasized.
Reciprocal associations between housing instability and youth criminal legal involvement: a scoping review
Authors: Almquist Lars , Walker Sarah Cusworth 
Published: April 2022

Abstract
Background
Youth experiencing homelessness have disproportionate contact with the criminal legal system. This system contact represents a critical inflection point for enhancing risk or opportunities for stabilization; however, the policy and scholarly traditions examining the criminal legal system have not traditionally incorporated housing or other social determinants as a central focus of intervention.

Methods
We conducted a scoping review using PRISMA-ScR guidelines to examine how the research literature is currently addressing housing within the context of youth involvement in the legal system. Databases searched included PubMed, Web of Science, and Academic Search Complete. Google Scholar was used to identify papers not indexed in the academic databases of interest. Database searches were conducted between September and December 2019 and articles were restricted to those published in English between the year 2000 and 2019. Key study components extracted included demographic information regarding each sample, type of article, study methodology, direction of effects of interest, outcome measures and primary findings, as well as theoretical frameworks engaged by the authors.

Results
The search results returned 2154 titles for review. After screening all 2154 titles, 75 met eligibility for inclusion. Abstract reviews were conducted for all 75 papers. 36 abstracts met eligibility criteria and underwent full-text review. Ultimately, 29 articles satisfied eligibility criteria and were included in this scoping review.

Conclusions
Publications are primarily focused on the social epidemiology of risk factors and behaviors determining youth justice contact, but relatively less so on studies of interventions targeting youth delinquency, crime reduction, or recidivism that included housing support. The lack of continuity in theorizing from epidemiology to applied science in this area represents a gap in the literature that is likely reducing the effectiveness of interventions to interrupt patterns of legal system contact for youth. Integrating a public health framework that emphasizes the upstream social determinants leading to contact with the youth justice system would represent a paradigm shift for the field that would have beneficial effects on long term health outcomes for youth.
Comprehensive study of 12th century wall painting fragments from the St. George Cathedral of the Yuryev Monastery in Veliky Novgorod (Russia) using complementary physico-chemical methods
Authors: Philippova O. S. , Dmitriev A. Yu. , Tsarevskaya T. J. , Dmitrieva S. O. 
Published: April 2022

Abstract
A total of 7 complementary methods have been applied to investigate unique pre-Mongolian 12th century wall paintings from the St. George Cathedral of the Yuriev Monastery in Veliky Novgorod, Russia. Both archaeological samples from the main space of the Cathedral and fragments in situ in the stairs tower of the Cathedral were studied. For the first time in Russia, sensitive neutron methods were used to study the elemental composition of pigments and plasters—neutron activation analysis and prompt gamma activation analysis. This research made it possible to determine elemental and mineral composition of the pigments and plasters used during creation of wall paintings; identify the technique of paintings; make assumptions about the different time of the paintings creation in the main space of the Cathedral and in its stairs tower; as well as reconstruct the presumable original view of the painting of the St. George figure. The discovery of the expensive lazurite pigment attested to the high status of the ktetor of the Cathedral’s murals. The obtained data were compared with Byzantine and Italian paintings of the same period churches.
An exploration into the use of Hansen solubility parameters for modelling reversed-phase chromatographic separations
Authors: Ribar David , Rijavec Tjaša , Kralj Cigić Irena 
Published: April 2022

AbstractThe suitability of Hansen solubility parameters as descriptors for modelling analyte retention during reversed-phase chromatographic experiments was investigated. A novel theoretical model using Hansen solubility parameters as the basis for a complete mathematical derivation of the model was developed. The theoretical model also includes the cavitation volumes of the analytes, which were calculated using ab initio density functional theory methods. A set of three homologous phthalates was used for experimental data collection and subsequent model construction. The training error and the generalization error of the model were additionally evaluated using a range of chemically diverse analytes. Statistical evaluation of the results revealed that the model is suitable for analyte retention prediction but is limited to the analytes used in the model construction. Therefore, the resulting theoretical model cannot be easily generalized. A retention anomaly attributed to the column temperature and mobile phase composition was experimentally observed and mathematically investigated.
Masked emotions: Do face mask patterns and colors affect the recognition of emotions?
Authors: Blazhenkova Olesya , Dogerlioglu-Demir Kivilcim , Booth Robert W. 
Published: April 2022

AbstractPrevious research has shown that face masks impair the ability to perceive social information and the readability of emotions. These studies mostly explored the effect of standard medical, often white, masks on emotion recognition. However, in reality, many individuals prefer masks with different styles. We investigated whether the appearance of the mask (pattern: angular vs. curvy and color: black vs. white) affected the recognition of emotional states. Participants were asked to identify the emotions on faces covered by masks with different designs. The presence of masks resulted in decreasing accuracy and confidence and increasing reaction times, indicating that masks impair emotion recognition. There were no significant effects of angularity versus curvature or color on emotion recognition, which suggests that mask design may not impair the recognition beyond the effect of mere mask wearing. Besides, we found relationships between individual difference variables such as mask wearing attitudes, mask design preferences, individual traits and emotion recognition. The majority of participants demonstrated positive attitudes toward mask wearing and preferred non-patterned black and white masks. Preferences for white masks were associated with better emotion recognition of masked faces. In contrast, those with negative attitudes toward masks showed marginally poorer performance in emotion recognition for masked faces, and preferred patterned more than plain masks, perhaps viewing masks as a fashion item rather than a necessity. Moreover, preferences to wear patterned masks were negatively related to actual wearing of masks indoors and perceived risks of COVID.
More than skin deep: about the influence of self-relevant avatars on inhibitory control
Authors: Friehs Maximilian A. , Dechant Martin , Schäfer Sarah , Mandryk Regan L. 
Published: April 2022

AbstractOne important aspect of cognitive control is the ability to stop a response in progress and motivational aspects, such as self-relevance, which may be able to influence this ability. We test the influence of self-relevance on stopping specifically if increased self-relevance enhances reactive response inhibition. We measured stopping capabilities using a gamified version of the stop-signal paradigm. Self-relevance was manipulated by allowing participants to customize their game avatar (Experiment 1) or by introducing a premade, self-referential avatar (Experiment 2). Both methods create a motivational pull that has been shown to increase motivation and identification. Each participant completed one block of trials with enhanced self-relevance and one block without enhanced self-relevance, with block order counterbalanced. In both experiments, the manipulation of self-relevance was effective in a majority of participants as indicated by self-report on the Player-Identification-Scale, and the effect was strongest in participants that completed the self-relevance block first. In those participants, the degree of subjectively experienced that self-relevance was associated with improvement in stopping performance over the course of the experiment. These results indicate that increasing the degree to which people identify with a cognitive task may induce them to exert greater, reactive inhibitory control. Consequently, self-relevant avatars may be used when an increase in commitment is desirable such as in therapeutic or training settings.
Antifungal activity of chitinase produced by Streptomyces species isolated from grassland soils in Futa Area, Akure
Authors: Ekundayo Fatuyi Olanipekun , Folorunsho Abisola Eniola , Ibisanmi Tope Abraham , Olabanji Olayinka Bukola 
Published: April 2022

Abstract
Background
This study was carried out to investigate the antifungal activity of chitinase produced by Streptomyces species isolated from grassland soils against selected pathogenic fungi, namely: Magnaporthe oryzae, Fusarium graminearum, Rhizoctonia solani, Puccinia species and Botyrtis cinerea. Chitinase produced by Streptomyces albus was purified consecutively with dialysis, gel filtration and ion- exchange chromatography, the test isolate can be exploited for large scale production of chitinase.

Results
Seven Streptomyces species (Streptomyces rimosus, S. albus, S. riseoflavus, S. fumosus, S. spiralis, S. aureofaciens and S. flavogriseus) isolated from three different grassland soils were screened based on the morphology and their ability to produce chitinase. S. rimosus, S. fumosus, S. albus and S. flavogriseus were able to produce chitinase, although the enzyme chitinase was found to be higher in Streptomyces albus. The effect of environmental factors were determined on Streptomyces albus being the best chitinolytic producing isolate. Temperature of 30οC was favourable for Streptomyces albus and pH 6.0 was a growth factor for maximum chitinase production. The activity of the enzyme was stimulated by the addition of metal ions like Mn2+, K+, Na+, Mg+, Fe2+, Ca2+ but Zn2+ inhibited chitinase activity. Chitinase activity was favoured by maltose as carbon source and NH4 (SO4)2 as nitrogen source. Culture filtrate of Streptomyces albus was able to inhibit the growth of all the selected pathogenic fungi namely Magnaporthe oryzae, Fusarium graminearum, Rhizoctonia solani, Puccinia species and Botyrtis cinerea whereas Streptomyces rimosus has the least inhibitory activity.

Conclusions
Streptomyces albus has the highest ability to produce chitinase which can act as antifungal for degradation of the cell wall of many phytopathogenic fungi.
Autophagy-related protein UvAtg14 contributes to mycelial growth, asexual reproduction, virulence and cell stress response in rice false smut fungus Ustilaginoidea virens
Authors: He Xiang , Yu Junjie , Pan Xiayan , Cao Huijuan , Yu Mina , Song Tianqiao , Qi Zhongqiang , Du Yan , Zhang Rongsheng , Liang Dong , Liu Yongfeng 
Published: April 2022

AbstractAutophagy is an evolutionarily conserved degradation process that degrades damaged proteins to maintain homeostasis and to protect cells against stress. In this study, we identified and characterized a critical autophagy-related protein, UvAtg14, in Ustilaginoidea virens, which is the ortholog of MoAtg14 in rice blast fungus Magnaporthe oryzea. UvAtg14 is co-localized with UvAtg8 (an autophagy marker protein) and is highly expressed at 1–3 days post-inoculation. Deletion of the UvATG14 gene blocked GFP-UvAtg8 trafficking and autophagic digestion and significantly reduced mycelial growth, asexual reproduction, and virulence of U. virens. UvATG14 deletion mutants also exhibited increased sensitivity to various abiotic stresses. Our findings indicate that UvAtg14 is a key autophagic protein and contributes to mycelial growth, conidia production, and pathogenicity in U. virens.
Influence of postural changes on haemodynamics in internal carotid artery bifurcation aneurysm using numerical methods
Authors: Ballambat Raghuvir Pai , Zuber Mohammad , Khader Shah Mohammed Abdul , Ayachit Anurag , Ahmad Kamarul Arifin bin , Vedula Rajanikanth Rao , Kamath Sevagur Ganesh , Shuaib Ibrahim Lutfi 
Published: April 2022

AbstractCerebral intracranial aneurysms are serious problems that can lead to stroke, coma, and even death. The effect of blood flow on cerebral aneurysms and their relationship with rupture are unknown. In addition, postural changes and their relevance to haemodynamics of blood flow are difficult to measure in vivo using clinical imaging alone. Computational simulations investigating the detailed haemodynamics in cerebral aneurysms have been developed in recent times not only to understand the progression and rupture but also for clinical evaluation and treatment. In the present study, the haemodynamics of a patient-specific case of a large aneurysm on the left side internal carotid bifurcation (LICA) and no aneurysm on the right side internal carotid bifurcation (RICA) was investigated. The simulation of these patient-specific models using fluid–structure interaction provides a valuable comparison of flow behavior between normal and aneurysm models. The influences of postural changes were investigated during standing, sleeping, and head-down (HD) position. Significant changes in flow were observed during the HD position and quit high arterial blood pressure in the internal carotid artery (ICA) aneurysm model was established when compared to the normal ICA model. The velocity increased abruptly during the HD position by more than four times (LICA and RICA) and wall shear stress by four times (LICA) to ten times (RICA). The complex spiral flow and higher pressures prevailing within the dome increase the risk of aneurysm rupture.
A regulatory GhBPE-GhPRGL module maintains ray petal length in Gerbera hybrida
Authors: Jiang Rui , Yuan Weichao , Yao Wei , Jin Xuefeng , Wang Xiaojing , Wang Yaqin 
Published: April 2022

AbstractThe molecular mechanism regulating petal length in flowers is not well understood. Here we used transient transformation assays to confirm that GhPRGL (proline-rich and GASA-like)—a GASA (gibberellic acid [GA] stimulated in Arabidopsis) family gene—promotes the elongation of ray petals in gerbera (Gerbera hybrida). Yeast one-hybrid screening assay identified a bHLH transcription factor of the jasmonic acid (JA) signaling pathway, here named GhBPE (BIGPETAL), which binds to the GhPRGL promoter and represses its expression, resulting in a phenotype of shortened ray petal length when GhBPE is overexpressed. Further, the joint response to JA and GA of GhBPE and GhPRGL, together with their complementary expression profiles in the early stage of petal growth, suggests a novel GhBPE-GhPRGL module that controls the size of ray petals. GhPRGL promotes ray petal elongation in its early stage especially, while GhBPE inhibits ray petal elongation particularly in the late stage by inhibiting the expression of GhPRGL. JA and GA operate in concert to regulate the expression of GhBPE and GhPRGL genes, providing a regulatory mechanism by which ray petals could grow to a fixed length in gerbera species.