bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of intrawork rest breaks on doctors’ performance and well-being: systematic review
Authors: O'Neill Aimee , Baldwin David , Cortese Samuele , Sinclair Julia 
Published: December 2022

ObjectivesTo summarise evidence on intrawork breaks and their associated effect on doctors’ well-being and/or performance at work.DesignSystematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 statement guidelinesData sourcesEmbase, PubMed, Web of Science (Core Collection) and PsychINFO were systematically searched on 6 June 2021.Eligibility criteriaNo restrictions were placed on language, study design or date of publication.Data extraction and analysisMethodological quality was appraised using Cochrane’s Risk of Bias (ROB-2), Cochrane’s Risk of Bias in Non-randomised Studies (ROBINS-I), and the Johanna Briggs Institute (JBI) checklists for cross-sectional, cohort and qualitative studies. Quantitative synthesis was not undertaken due to substantial heterogeneity of design and outcomes. Results are presented narratively.ResultsDatabase searches returned 10 557 results and searches of other sources returned two additional records. Thirty-two papers were included in the systematic review, comprised of 29 unique studies, participants and topics and 3 follow-up studies. A variety of well-being and performance outcome measures were used. Overall, findings indicate that intrawork breaks improved some measures of well-being and/or work performance. However, methodological quality was judged to be low with a high risk of bias in most included studies.DiscussionUsing existing evidence, it is not possible to conclude with confidence whether intrawork breaks improve well-being and/or work performance in doctors. There is much inconsistency regarding how breaks are defined, measured and the outcomes used to assess effectiveness. Future research should seek to: (a) define and standardise the measurement of breaks, (b) use valid, reliable outcome measures to evaluate their impact on well-being and performance and (c) minimise the risk of bias in studies where possible.PROSPERO registration numberCRD42020156924;https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=156924.
How representative is the Victorian Emergency Minimum Dataset (VEMD) for population-based injury surveillance in Victoria? A retrospective observational study of administrative healthcare data
Authors: Rezaei-Darzi Ehsan , Berecki-Gisolf Janneke , Fernando Dasamal Tharanga 
Published: December 2022

ObjectiveThe Victorian Emergency Minimum Dataset (VEMD) is a key data resource for injury surveillance. The VEMD collects emergency department data from 39 public hospitals across Victoria; however, rural emergency care services are not well captured. The aim of this study is to determine the representativeness of the VEMD for injury surveillance.DesignA retrospective observational study of administrative healthcare data.Setting and participantsInjury admissions in 2014/2015–2018/2019 were extracted from the Victorian Admitted Episodes Dataset (VAED) which captures all Victorian hospital admissions; only cases that arrived through a hospital’s emergency department (ED) were included. Each admission was categorised as taking place in a VEMD-contributing versus a non-VEMD hospital.ResultsThere were 535 477 incident injury admissions in the study period, of which 517 207 (96.6%) were admitted to a VEMD contributing hospital. Male gender (OR 1.13 (95% CI 1.10 to 1.17)) and young age (age 0–14 vs 45–54 years, OR 4.68 (95% CI 3.52 to 6.21)) were associated with VEMD participating (vs non-VEMD-participating) hospitals. Residing in regional/rural areas was negatively associated with VEMD participating (vs non-VEMD participating) hospitals (OR=0.11 (95% CI 0.10 to 0.11)). Intentional injury (assault and self-harm) was also associated with VEMD participation.ConclusionsVEMD representativeness is largely consistent across the whole of Victoria, but varies vastly by region, with substantial under-representation of some areas of Victoria. By comparison, for injury surveillance, regional rates are more reliable when based on the VAED. For local ED-presentation rates, the bias analysis results can be used to create weights, as a temporary solution until rural emergency services injury data is systematically collected and included in state-wide injury surveillance databases.
Feasibility and potential effects of breathing exercise for chronic pain management in breast cancer survivors: study protocol of a phase II randomised controlled trial
Authors: Wang Haiying , Tan Jing-Yu (Benjamin) , Wang Tao , Liu Xian-Liang , Bressington Daniel , Zheng Si-Lin , Huang Hou-Qiang 
Published: December 2022

IntroductionChronic pain is a common symptom significantly affecting the quality of life of breast cancer survivors. Despite the achievement of pharmacological interventions, the barriers associated with this approach such as inaccessibility, misuse and side effects drive research into effective non-pharmacological interventions to improve chronic pain management, quality of life, anxiety and depression. Breathing exercise (BE) can be a promising option, but research evidence is sparse. This pilot study aims to examine the feasibility and preliminary effect of using an evidence-based BE intervention for chronic pain management in breast cancer survivors.Method and analysisThis study will be a two-parallel-arm, open-labelled, phase II randomised controlled trial with 1:1 allocation. Seventy-two participants will be recruited from a tertiary hospital in China and randomly allocated to either a BE intervention group (n=36) or a control group (n=36). The participants in the intervention group will receive the usual care, a pain information booklet and a 4-week self-administered BE intervention; the participants in the control group will receive the usual care and the pain information booklet only. The assessment will be conducted at three time points: baseline (week 0), immediately after the intervention completion (week 5) and 4 weeks after the intervention completion (week 9). The primary outcomes will be the acceptability and feasibility assessment of the study protocol and methodological procedures. The secondary outcomes will be the effects of BE on pain, quality of life, anxiety and depression in breast cancer survivors. Descriptive statistics will be applied to present the primary outcomes and the Generalised Estimating Equation Model will be utilised to analyse the clinical outcomes.Ethics and disseminationThis study has received ethical approvals from the Human Research Ethics Committee at Charles Darwin University (H21089) and the Clinical Trial Ethics Committee at the Affiliated Hospital of Southwest Medical University (KY2022107). Findings from this study will be presented at academic conferences and submitted to peer-reviewed journals for publication.Trial registration numberClinicalTrials.gov:NCT05257876.
Association between SARS-CoV-2 infection and the physical fitness of young-adult cadets: a retrospective case–control study
Authors: Peretz Lidor , Grossman Akiva , Saeed Salih J , Appleboim-Refael Talia , Zloof Yair , Friedensohn Limor , Shapira Shachar , Shlaifer Amir , Grotto Itamar 
Published: December 2022

ObjectivesTo determine the association of symptomatic and asymptomatic mild COVID-19 and the SARS-CoV-2 viral load with the physical fitness of army cadets.DesignA retrospective case–control study.SettingOfficers’ Training School of the Israel Defense Forces.ParticipantsThe study included all cadets (age, 20.22±1.17 years) in the combatant (n=597; 514 males, 83 females; 33 infected, all males) and non-combatant (n=611; 238 males, 373 females; 91 infected, 57 females, 34 males) training courses between 1 August 2020 and 28 February 2021. COVID-19 outbreaks occurred in September 2020 (non-combatants) and January 2021(combatants).Primary and secondary outcome measuresThe primary outcome measures were the aerobic (3000 m race) and anaerobic (combatant/non-combatant-specific) physical fitness mean score differences (MSDs) between the start and end of the respective training courses in infected and non-infected cadets. Secondary outcome measures included aerobic MSD associations with various COVID-19 symptoms and SARS-CoV-2 viral loads.ResultsSARS-CoV-2 infection led to declined non-combatant and combatant aerobic fitness MSD (14.53±47.80 vs –19.19±60.89 s; p<0.001 and –2.72±21.74 vs –23.63±30.92 s; p<0.001), but not anaerobic. The aerobic physical fitness MSD decreased in symptomatic cadets (14.69±44.87 s) and increased in asymptomatic cadets (–3.79±31.07 s), but the difference was statistically insignificant (p=0.07). Symptomatic cadets with fever (24.70±50.95 vs –0.37±33.87 s; p=0.008) and headache (21.85±43.17 vs 1.69±39.54 s; p=0.043) had more positive aerobic physical fitness MSD than asymptomatic cadets. The aerobic fitness decline was negatively associated with viral load assessed by the RNA-dependent RNA polymerase (n=61; r = –0.329; p=0.010), envelope (n=56; r = –0.385; p=0.002) and nucleus (n=65; r = –0.340; p=0.010) genes.ConclusionsSARS-CoV-2 infection was associated with a lingering decline in aerobic, but not anaerobic, fitness in symptomatic and asymptomatic young adults, suggesting possible directions for individualised symptom-dependent and severity-dependent rehabilitation plans’ optimisation.
Can quantitative susceptibility mapping help diagnose and predict recovery of concussion in children? An A-CAP study
Authors: Sader Nicholas , Gobbi David , Goodyear Brad , Frayne Richard , Ware Ashley L , Beauchamp Miriam H , Craig William R , Doan Quynh , Zemek Roger , Riva-Cambrin Jay , Yeates Keith Owen 
Published: December 2022

BackgroundQuantitative susceptibility mapping (QSM) is an MRI technique that is a potential biomarker for concussion. We performed QSM in children following concussion or orthopaedic injury (OI), to assess QSM performance as a diagnostic and prognostic biomarker.MethodsChildren aged 8–17 years with either concussion (N=255) or OI (N=116) were recruited from four Canadian paediatric emergency departments and underwent QSM postacutely (2–33 days postinjury) using 3 Tesla MRI. QSM Z-scores within nine regions of interest (ROI) were compared between groups. QSM Z-scores were also compared with the 5P score, the current clinical benchmark for predicting persistent postconcussion symptoms (PPCS), at 4 weeks postinjury, with PPCS defined using reliable change methods based on both participant and parent reports.ResultsConcussion and OI groups did not differ significantly in QSM Z-scores for any ROI. Higher QSM Z-scores within frontal white matter (WM) independently predicted PPCS based on parent ratings of cognitive symptoms (p=0.001). The combination of frontal WM QSM Z-score and 5P score was better at predicting PPCS than 5P score alone (p=0.004). The area under the curve was 0.72 (95% CI 0.63 to 0.81) for frontal WM susceptibility, 0.69 (95% CI 0.59 to 0.79) for the 5P score and 0.74 (95% CI 0.65 to 0.83) for both.ConclusionThe findings suggest that QSM is a potential MRI biomarker that can help predict PPCS in children with concussion, over and above the current clinical benchmark, and thereby aid in clinical management. They also suggest a frontal lobe substrate for PPCS, highlighting the potential for QSM to clarify the neurophysiology of paediatric concussion.
Hepatitis A and B vaccination in gbMSM in Ireland: findings from the European MSM Internet Survey 2017 (EMIS-2017)
Authors: White Philippa , O'Donnell Kate , Brennan Aline , Davoren Martin , Lyons Fiona , Quinlan Mick , Foley Bill , Hurley Caroline , Igoe Derval , Barrett Peter 
Published: December 2022

ObjectivesGay, bisexual and other men who have sex with men (gbMSM) have a higher risk of acquiring hepatitis A and B viruses (HAV and HBV) than the general population and are recommended for vaccination against both in Ireland. This study aims to determine the prevalence of self-reported HAV and HBV infection and vaccination among gbMSM in Ireland and explore factors associated with self-reported HAV and HBV vaccination among gbMSM.MethodsThis study analysed Irish data from the European MSM Internet Survey 2017 (EMIS-2017) to measure the prevalence of self-reported HAV and HBV infection and vaccination among gbMSM in Ireland. Multivariable logistic regression was used to explore the associations between sociodemographic, healthcare-related and behavioural factors and self-reported vaccination.ResultsThere were 2083 EMIS-2017 respondents in Ireland. Among HIV-negative gbMSM, 4.6% and 4.4% reported previous HAV and HBV infection, respectively, and 51% and 57% reported the receipt of one or more vaccine dose for HAV and HBV, respectively. In the multivariable analysis, HIV-negative gbMSM had lower odds of self-reported HAV vaccination if they lived outside the capital, Dublin (aOR 0.61, 95% CI: 0.48 to 0.78), had no third-level education (aOR 0.65, 95% CI: 0.45 to 0.92), were not tested for HIV in the last year (aOR 0.39, 95% CI: 0.31 to 0.50), had never tried to obtain pre-exposure prophylaxis (PrEP, aOR 0.60, 95% CI: 0.38 to 0.96) and had not been diagnosed with a sexually transmitted infection (STI) in the previous year (aOR 0.42, 95% CI: 0.28 to 0.63). Similar associations were observed for self-reported HBV vaccination.ConclusionsSelf-reported vaccination against HAV and HBV among gbMSM in Ireland is high, but the level of vaccination remains insufficient to protect against future HAV and HBV infections and outbreaks. Efforts to increase vaccination coverage among gbMSM should focus on men who live outside the capital, have lower educational attainment and do not engage with sexual health services.
Processing effects on the starch and fibre composition of Canadian pulses
Authors: Babatunde Olufemi O. , Cargo-Froom Cara L. , Ai Yongfeng , Newkirk Rex W. , Marinangeli Christopher P.F. , Shoveller Anna K. , Columbus Daniel A. 
Published: December 2022

Starch and fibre contribute to the energy components and add functionality to the end-product feed ingredients. An understanding of the impact of processing on carbohydrate content will support accurate formulation of feed. Six ingredients, grown or sourced in Canada, were used in this study. They included five pulses, Amarillo peas, Dun peas, chickpeas, lentils, and faba beans, and soybean meal (SBM) as a comparison. All ingredients were ground into fine or coarse products and then pelleted at one of three different temperatures. Grinding reduced the total starch (TS) content of Amarillo peas and chickpeas ( P < 0.05), crude fibre (CF) in Dun peas ( P < 0.05), and total dietary fibre (TDF) and insoluble fibre (IDF) in lentils ( P < 0.05). Grinding only affected soluble fibre (SDF) in chickpeas. The effect of pelleting was variable for TDF across pulses. Pelleting did not affect the SDF content of pulses ( P > 0.05). Finely processed SBM had higher ( P < 0.05) TS, TDF, and IDF content than coarsely processed SBM. Results indicate that grinding and pelleting could affect the starch and fibre composition of some pulses.
Flavored axions and the flavor problem
Authors: Giraldo Yithsbey , Martinez R. , Rojas Eduardo , Salazar Juan C. 
Published: December 2022

AbstractA Peccei-Quinn (PQ) symmetry is proposed, in order to generate in the Standard Model (SM) quark sector a realistic mass matrix ansatz with five texture-zeros. Limiting our analysis to Hermitian mass matrices we show that this requires a minimum of 4 Higgs doublets. This model allows assigning values close to 1 for several Yukawa couplings, giving insight into the origin of the mass scales in the SM. Since the PQ charges are non-universal the model features Flavor-Changing Neutral Currents (FCNC) at the tree level. From the analytical expressions for the FCNC we report the allowed region in the parameter space obtained from the measurements of branching ratios of semileptonic meson decays.
Mesenchymal Stem Cell–mediated Image-guided Sodium Iodide Symporter (NIS) Gene Therapy Improves Survival of Glioblastoma-bearing Mice
Authors: Kitzberger Carolin , Spellerberg Rebekka , Han Yang , Schmohl Kathrin A. , Stauss Christina , Zach Christian , Kälin Roland E. , Multhoff Gabriele , Eiber Matthias , Schilling Franz , Glass Rainer , Weber Wolfgang A. , Wagner Ernst , Nelson Peter J. , Spitzweg Christine 
Published: December 2022

AbstractPurpose:Mesenchymal stem cells (MSC) have emerged as cellular-based vehicles for the delivery of therapeutic genes in cancer therapy based on their inherent tumor-homing capability. As theranostic gene, the sodium iodide symporter (NIS) represents a successful target for noninvasive radionuclide-based imaging and therapy. In this study, we applied genetically engineered MSCs for tumor-targeted NIS gene transfer in experimental glioblastoma (GBM)—a tumor with an extremely poor prognosis.Experimental Design:A syngeneic, immunocompetent GL261 GBM mouse model was established by subcutaneous and orthotopic implantation. Furthermore, a subcutaneous xenograft U87 model was used. Bone marrow–derived MSCs were stably transfected with a NIS-expressing plasmid driven by the constitutively active cytomegalovirus promoter (NIS-MSC). After multiple or single intravenous injection of NIS-MSCs, tumoral iodide uptake was monitored in vivo using 123I-scintigraphy or 124I-PET. Following validation of functional NIS expression, a therapy trial with 131I was performed on the basis of the most optimal application regime as seen by 124I-PET imaging in the orthotopic approach.Results:A robust tumoral NIS-specific radionuclide accumulation was observed after NIS-MSC and radioiodide application by NIS-mediated in vivo imaging. NIS immunofluorescence staining of GBM and non-target tissues showed tumor-selective MSC homing along with NIS expression. Application of therapeutically effective 131I led to significantly delayed tumor growth and prolonged median survival after NIS-MSC treatment as compared with controls.Conclusions:A strong tumor-selective recruitment of systemically applied MSCs into GBM was found using NIS as reporter gene followed by successful therapeutic application of radioiodide demonstrating the potential use of NIS-based MSCs as therapy vehicles as a new GBM therapy approach.
Design and miniaturization of a microsystem to power biomedical implants using grey wolf optimizer-based cuckoo search algorithm
Authors: Ouacha Brahim , Bouyghf Hamid , Nahid Mohammed , Abenna Said 
Published: December 2022

<p>One of the greatest techniques, inductive coupling is frequently utilized in the biomedical sector for wireless energy transfer to implants. The aim of this article is to develop and analyze the effect of inductor geometrical characteristics, distance between transmitter (TX) and receiver (RX) and also the operating frequency on the wireless power transfer system, using grey wolf optimizer-based cuckoo search (GWO-CS) algorithm. Power transfer efficiency (PTE), power provided to load, and other critical components must all be improved or maximized and miniaturaze the microsystem proposed. The invention, design, and optimization of coils square spirals in a wireless energy transfer system using a resonant inductive link are the emphasis of this paper. The GWO-CS approach is evaluated to existing methods, demonstrated by simulations and to demonstrate the effectiveness of the suggested strategy.</p>
Liver segmentation using marker controlled watershed transform
Authors: Napte Kiran Malhari , Mahajan Anurag 
Published: December 2022

<span lang="EN-US">The largest organ in the body is the liver and primarily helps in metabolism and detoxification. Liver segmentation is a crucial step in liver cancer detection in computer vision-based biomedical image analysis. Liver segmentation is a critical task and results in under-segmentation and over-segmentation due to the complex structure of abdominal computed tomography (CT) images, noise, and textural variations over the image. This paper presents liver segmentation in abdominal CT images using marker-based watershed transforms. In the pre-processing stage, a modified double stage gaussian filter (MDSGF) is used to enhance the contrast, and preserve the edge and texture information of liver CT images. Further, marker controlled watershed transform is utilized for the segmentation of liver images from the abdominal CT images. Liver segmentation using suggested MDSGF and marker-based watershed transform help to diminish the under-segmentation and over-segmentation of the liver object. The performance of the proposed system is evaluated on the LiTS dataset based on Dice score (DS), relative volume difference (RVD), volumetric overlapping error (VOE), and Jaccard index (JI). The proposed method gives (Dice score of 0.959, RVD of 0.09, VOE of 0.089, and JI of 0.921).</span>
Anti-resonant based nested terahertz fiber design for illicit drugs detection
Authors: Tahhan Shaymaa Riyadh , Aljobouri Hadeel K. , Altahan Baraa Riyadh 
Published: December 2022

Anti-resonant hollow-core fibers (AR-HCFs) have gotten a lot of interest lately because of their potential uses in different medical sensing applications. In this work, an anti-resonant THz fiber (ATF) biosensor is implemented to check for illicit drugs and identify them at airport borders. Three different unlawful medicines have been chosen for the proposed design, Cocaine, Amphetamine, and Ketamine. A novel hollow-core anti-resonant fibers (HC-ARF) Matryoshka shape sensor has been designed for detecting the illegal drugs. The proposed design shows a robust sensitivity ranging from 99.8-99.9% and shallow confinement losses compared to other articles in the same field, as the higher losses are 9.3×10-4 dB/m with cocaine. Bending loss lessens as the bending radius rises while it is still below 1 dB/cm for radius more than 10 cm. The numerical simulation outcomes displayed that the designed HC-ARF has 0.0643±0.0238 ps/THz/cm flat dispersion at 0.6-2 THz. As the first application in this field, this work will be the first published in the literature.
Octa-band reconfigurable monopole antenna frequency diversity 5G wireless
Authors: Abd Ali Kadhum , Rasool Jamal Mohammed 
Published: December 2022

<span lang="EN-US">An octa-band frequency-reconfigurable antenna (28×14×1.5 mm<sup>3</sup>) with a broad tuning range is shown. Antenna mode1 (4.31 GHz) works in one single-band mode and two dual-band in modes 2 and 3 (i.e., 3.91 and 5.9 GHz) as well as one tri-band in mode 4 (i.e., 3.09, 5.65, and 7.92 GHz) based on the switching situation of the antenna. Changing capacitance for frequency reconfigurability is accomplished with the use of lumped components. The antenna’s observed tuning spans from 3.09 GHz to 7.92 GHz. for all the resonant bands, the suggested antenna has a voltage standing waves ratio (VSWR)&lt;1.45 except for one band with a VSWR&lt;1.85. From 70.57% to 97.93%, the suggested structure’s radiation efficiency may be calculated. For a better understanding proposed antenna’s far field and scattering characteristics, we used CST Microwave Studio 2021. We may conclude that our suggested antenna is suitable for today’s wireless applications, which need multiband and multimode small antennas. Using a small stainless-steel wire as a switch, a prototype of the antenna design is built and tested to verify the simulation findings. The suggested reconfigurable antenna’s strong concordance between simulated and measured findings.</span>