bluuebunny/crossref_metadata_2025_split huggingface dataset:
Civile tyske flygtninge i Hørup sogn på Sydals 1945-47
Authors: Marckmann Anton 
Published: May 2022

Da den russiske hær i januar 1945 rykkede frem mod de tyske militære styrker på Østfronten, udløstes samtidig massive, civile flygtningestrømme. På tysk forlangende kom der en del til Danmark, enten over landegrænsen eller med skib over Østersøen. Der kom omkring 250.000 tyske flygtninge til Danmark i månederne inden den tyske kapitulation. Disse flygtninge var indkvarteret rundt om på skoler og andre offentlige bygninger, langt de fleste blev efter kort tid indsat i interneringslejre. Én af disse lejre lå i Hørup på Sydals. Frem til befrielsen var det tyske besættelsesmyndigheder, der havde ansvaret for flygtningene, mens det efter maj 1945 var de danske myndigheder, der stod for behandlingen af de tyske flygtninge i Danmark. I artiklen rettes fokus mod forholdene for flygtningene, der var indkvarteret i Hørup sogn.
Participation of Carbohydrate Structures in the Formation of Complex Structure of Hemocyanins from Haliotis tuberculata
Authors: Dolashki Alexander , Daskalova Asya , Pisareva Emilya , Petrova Ventsislava , Dolashka Pavlina 
Published: May 2022

Glycosylation plays an important role in many important processes in organisms. Their participation in the construction of the tertiary structure and immunotherapeutic activity of the hemocyanin Rapana venosa (RvH) from the Black Sea has been presented. Based on these results, the importance of glycans in organization of the structure of hemocyanin from the abdominal mollusk Haliotis tuberculata (HtH) was also studied.
After incubation of both isoforms HtH1 and HtH2 with yeast Saccharomyces cerevisiae and enzyme Zymolyase, fractions with lower molecular weight (MW) between 45 and 65 kDa, which corresponds to MW of functional units (FUs) of hemocyanins, was identified. A comparative analysis of 10% SDS PAGE assays confirmed the depolymerization of the subunits HtH1 and HtH2 due to the specific glycosidase in the yeast S. cerevisiae and the enzyme Zymolyase. The presented results confirm our hypothesis that glycans are involved in the formation of the structural subunits of HtH.
Melatonin Receptor 1B Polymorphisms and Reproductive Failure – a Pilot Study
Authors: Robeva Ralitsa , Marinova Elena , Nikolaev Georgi , Andonova Silvia , Savov Alexey , Tanev Dobromir , Nikolov Gueorgui , Konakchieva Rossitza 
Published: May 2022

The present study aimed to investigate the possible associations between the melatonin receptor 1B (MTNR1b) genetic polymorphisms and the presence of reproductive disturbances due to spontaneous abortion and implantation failure leading to pregnancy loss. The patients group included 35 women presenting with one or more miscarriages and/or implantation failure. Another 36 healthy women without history of implantation failure or miscarriages and with at least one birth served as a control group. Genomic DNA was extracted and genotyping for the MTNR1b polymorphisms rs1562444, rs10830962 and rs10830963 was performed by PCR-RFLP analysis. The genotype distribution of the investigated MTNR1b polymorphisms in patients with reproductive failure did not differ significantly to the group of women with at least one birth (p > 0.05 for all). Nevertheless, the presence of a haplotype rs1562444 AA rs10830962 GG was significantly less common in women with miscarriages or implantation failure than in women with at least one birth (2.9% vs. 22.2%, p = 0.028). We suggest that the haplotype might be protective against implantation failure and spontaneous miscarriage. Additionally, rs1562444 AA genotype was not found in women with recurrent pregnancy loss. Studies in larger populations are necessary to reveal the proper associations between different MTNR1b haplotypes, ovarian function and reproductive failure.
A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes
Authors: Chu Xiaojing , Janssen Anna WM , Koenen Hans , Chang Linzhung , He Xuehui , Joosten Irma , Stienstra Rinke , Kuijpers Yunus , Wijmenga Cisca , Xu Cheng-Jian , Netea Mihai G , Tack Cees J , Li Yang 
Published: May 2022

Background:The large inter-individual variability in immune-cell composition and function determines immune responses in general and susceptibility o immune-mediated diseases in particular. While much has been learned about the genetic variants relevant for type 1 diabetes (T1D), the pathophysiological mechanisms through which these variations exert their effects remain unknown.Methods:Blood samples were collected from 243 patients with T1D of Dutch descent. We applied genetic association analysis on >200 immune-cell traits and >100 cytokine production profiles in response to stimuli measured to identify genetic determinants of immune function, and compared the results obtained in T1D to healthy controls.Results:Genetic variants that determine susceptibility to T1D significantly affect T cell composition. Specifically, the CCR5+ regulatory T cells associate with T1D through the CCR region, suggesting a shared genetic regulation. Genome-wide quantitative trait loci (QTLs) mapping analysis of immune traits revealed 15 genetic loci that influence immune responses in T1D, including 12 that have never been reported in healthy population studies, implying a disease-specific genetic regulation.Conclusions:This study provides new insights into the genetic factors that affect immunological responses in T1D.Funding:This work was supported by an ERC starting grant (no. 948207) and a Radboud University Medical Centre Hypatia grant (2018) to YL and an ERC advanced grant (no. 833247) and a Spinoza grant of the Netherlands Association for Scientific Research to MGN CT received funding from the Perspectief Biomarker Development Center Research Programme, which is (partly) financed by the Netherlands Organisation for Scientific Research (NWO). AJ was funded by a grant from the European Foundation for the Study of Diabetes (EFSD/AZ Macrovascular Programme 2015). XC was supported by the China Scholarship Council (201706040081).
Prospective quantitative gene expression analysis of kallikrein-related peptidase KLK10 as a diagnostic biomarker for childhood acute lymphoblastic leukemia
Authors: Ahmad Shwan Majid , Ahmed Basima Sadq , Khidhir Karzan Ghafur , Rahman Heshu Sulaiman 
Published: May 2022

Background
The most common malignancy in children is acute lymphoblastic leukemia (ALL). This study aimed to explore KLK10 mRNA expression as a potential diagnostic biomarker for ALL in children and to examine the effect of chemotherapy on KLK10 mRNA expression following the induction and after three months of receiving chemotherapy.

Methods
In this prospective study, total RNA was extracted from blood samples of 23 pediatric ALL patients on diagnosis, after one month and three months of receiving chemotherapy. Healthy pediatric volunteers (n = 12) were selected as control individuals. After cDNA synthesis, KLK10 mRNA gene expression levels were quantified using quantitative real-time PCR (qRT-PCR).

Results
KLK10 mRNA expression levels were significantly decreased in leukemic cells compared to their levels in cells of normal blood samples (p = 0.0001). KLK10 expression levels in ALL patients after one month and three months of receiving chemotherapy decreased compared to normal blood samples (p < 0.0001 and p = 0.0175 respectively). The expression level of KLK10 mRNA in ALL patients after one month of chemotherapy was decreased compared to their level on diagnosis (p = 0.4413). KLK10 mRNA expression levels in ALL patients after three months of chemotherapy were increased compared to their level on diagnosis (p = 0.0602). The ROC curve illustrated that KLK10 mRNA expression could very efficiently discriminate ALL patients from normal counterparts (AUC=0.886, 95% CI [0.7720–1.000], SE = 0.0582, p = 0.0004).

Conclusion
KLK10 mRNA expression could serve as a potential diagnostic molecular biomarker for ALL in children.
Democracia, Constitución y probidad pública y privada
Authors: Peña Torres Marisol 
Published: May 2022

Ponencia presentada por la Ministra del Tribunal Constitucional y ex Presidenta del mismo, Sra. Marisol Peña Torres, en la inauguración del Magíster en Derecho de la Universidad Católica de Temuco, presentada con fecha 28 de abril de 2016.
En su escrito, la Ministra aborda las imbricaciones existentes entre los extremos mencionados, esto es, democracia, Constitución y probidad, jalonándola de precisas referencias a diversos pronunciamientos del máximo intérprete de la Ley Fundamental sobre la materia.
Sentencia en contra del Registro Civil por desconocer derechos hereditarios a hija no matrimonial (Corte de Apelaciones de Talca)
Authors: Palavecino Cáceres Adriana 
Published: May 2022

Sentencia
Talca, trece de mayo de dos mil trece.
VISTO:
Que, a fojas 15 se presenta don MANUEL JOSÉ RETAMAL ÁVILA, abo-gado, domiciliado en calle Maipú N° 400, oficina 4 de la ciudad de Cau-quenes, en representación de doña ELIANA DEL CARMEN JARA, R.U.N. 4.817.748-4, labores de hogar, domiciliada en sector Tavolguen, Km. 9, ca-mino a Chanco, comuna de Cauquenes, interponiendo recurso de protección en contra de la Directora Regional del Maule del Servicio de Registro Civil e Identificación, doña Cristina Andrea Bravo Castro, domiciliada en calle en calle Uno Oriente N°835, de la ciudad de Talca.
New and Updated Recommendations for the Treatment of Juvenile Idiopathic Arthritis–Associated Uveitis and Idiopathic Chronic Anterior Uveitis
Authors: Foeldvari Ivan , Maccora Ilaria , Petrushkin Harry , Rahman Najiha , Anton Jordi , de Boer Joke , Calzada‐Hernández Joan , Carreras Elisa , Diaz Jesus , Edelsten Clive , Angeles‐Han Sheila T. , Heiligenhaus Arnd , Miserocchi Elisabetta , Nielsen Susan , Saurenmann Rotraud K. , Stuebiger Nicole , Baquet‐Walscheid Karoline , Furst Daniel , Simonini Gabriele 
Published: May 2022

ObjectiveThe Multinational Interdisciplinary Working Group for Uveitis in Childhood identified the need to update the current guidelines, and the objective here was to produce this document to guide clinicians managing children with juvenile idiopathic arthritis–associated uveitis (JIAU) and idiopathic chronic anterior uveitis (CAU).MethodsThe group analyzed the literature published between December 2014 and June 2020 after a systematic literature review conducted by 2 clinicians. Pediatric rheumatologists were paired with ophthalmologists to review the eligible 37 publications. The search criteria were selected to reflect those used for the 2018 Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) recommendations, in order to provide an update, rather than a replacement for that publication. The summary of the current evidence for each SHARE recommendation was presented to the expert committee. These recommendations were then discussed and revised during a video consensus meeting on January 22, 2021, with 14 voting participants, using a nominal group technique to reach consensus.ResultsJIAU treatment was extended to include CAU. Fourteen recommendations regarding treatment of JIAU und CAU with >90% agreement were accepted.ConclusionAn update to the previous 2018 SHARE recommendations for the treatment of children with JIAU with the addition of CAU was created using an evidence‐based consensus process. This guideline should help support clinicians to care for children and young people with CAU.
Event‐triggered adaptive fault‐tolerant vibration control for a flexible robotic manipulator based on the partial differential equation model
Authors: Li Le , Liu Jinkun 
Published: May 2022

SummaryThis study investigates the event‐triggered adaptive control issues of a flexible manipulator when the control system is implemented over a network. The flexible manipulator has two actuators, which receive signals from the controller through the communication network. Given the limited communication problem of network and potential actuator failures, an event‐triggered adaptive fault‐tolerant controller is proposed based on the partial differential equation model. In our design, two event‐triggering mechanisms are introduced to avoid continuous signal transmission from the controller to the actuator. Then, an adaptive law using the projection mapping operator is designed to compensate for the impact of actuator failures. By employing the proposed control scheme, angular position tracking and vibration elimination can be achieved while reducing signal transmission, regardless of actuator failure. All closed‐loop signals are proved to be uniformly ultimately bounded. The control performance is demonstrated by numerical simulations.
Metasurface‐Enhanced Infrared Spectroscopy: An Abundance of Materials and Functionalities
Authors: John‐Herpin Aurelian , Tittl Andreas , Kühner Lucca , Richter Felix , Huang Steven H. , Shvets Gennady , Oh Sang‐Hyun , Altug Hatice 
Published: May 2022

AbstractInfrared spectroscopy provides unique information on the composition and dynamics of biochemical systems by resolving the characteristic absorption fingerprints of their constituent molecules. Based on this inherent chemical specificity and the capability for label‐free, noninvasive, and real‐time detection, infrared spectroscopy approaches have unlocked a plethora of breakthrough applications for fields ranging from environmental monitoring and defense to chemical analysis and medical diagnostics. Nanophotonics has played a crucial role for pushing the sensitivity limits of traditional far‐field spectroscopy by using resonant nanostructures to focus the incident light into nanoscale hot‐spots of the electromagnetic field, greatly enhancing light–matter interaction. Metasurfaces composed of regular arrangements of such resonators further increase the design space for tailoring this nanoscale light control both spectrally and spatially, which has established them as an invaluable toolkit for surface‐enhanced spectroscopy. Starting from the fundamental concepts of metasurface‐enhanced infrared spectroscopy, a broad palette of resonator geometries, materials, and arrangements for realizing highly sensitive metadevices is showcased, with a special focus on emerging systems such as phononic and 2D van der Waals materials, and integration with waveguides for lab‐on‐a‐chip devices. Furthermore, advanced sensor functionalities of metasurface‐based infrared spectroscopy, including multiresonance, tunability, dielectrophoresis, live cell sensing, and machine‐learning‐aided analysis are highlighted.
Strain‐Driven Auto‐Detachable Patterning of Flexible Electrodes
Authors: Lv Zhisheng , Wang Changxian , Wan Changjin , Wang Renheng , Dai Xiangyu , Wei Jiaqi , Xia Huarong , Li Wenlong , Zhang Wei , Cao Shengkai , Zhang Feilong , Yang Haiyue , Loh Xian Jun , Chen Xiaodong 
Published: May 2022

AbstractFlexible electrodes that are multilayer, multimaterial, and conformal are pivotal for multifunctional wearable electronics. Traditional electronic circuits manufacturing requires substrate‐supported transfer printing, which limits their multilayer integrity and device conformability on arbitrary surfaces. Herein, a “shrinkage‐assisted patterning by evaporation” (SHAPE) method is reported, by employing evaporation‐induced interfacial strain mismatch, to fabricate auto‐detachable, freestanding, and patternable electrodes. The SHAPE method utilizes vacuum‐filtration of polyaniline/bacterial cellulose (PANI/BC) ink through a masked filtration membrane to print high‐resolution, patterned, and multilayer electrodes. The strong interlayer hydrogen bonding ensures robust multilayer integrity, while the controllable evaporative shrinking property of PANI/BC induces mismatch between the strains of the electrode and filtration membrane at the interface and thus autodetachment of electrodes. Notably, a 500‐layer substrateless micro‐supercapacitor fabricated using the SHAPE method exhibits an energy density of 350 mWh cm−2 at a power density of 40 mW cm−2, 100 times higher than reported substrate‐confined counterparts. Moreover, a digital circuit fabricated using the SHAPE method functions stably on a deformed glove, highlighting the broad wearable applications of the SHAPE method.
Nanochitin and Nanochitosan: Chitin Nanostructure Engineering with Multiscale Properties for Biomedical and Environmental Applications
Authors: Lee Suyoung , Hao Lam Tan , Park Jeyoung , Oh Dongyeop X. , Hwang Dong Soo 
Published: May 2022

AbstractNanochitin and nanochitosan (with random‐copolymer‐based multiscale architectures of glucosamine andN‐acetylglucosamine units) have recently attracted immense attention for the development of green, sustainable, and advanced functional materials. Nanochitin and nanochitosan are multiscale materials from small oligomers, rod‐shaped nanocrystals, longer nanofibers, to hierarchical assemblies of nanofibers. Various physical properties of chitin and chitosan depend on their molecular‐ and nanostructures; translational research has utilized them for a wide range of applications (biomedical, industrial, environmental, and so on). Instead of reviewing the entire extensive literature on chitin and chitosan, here, recent developments in multiscale‐dependent material properties and their applications are highlighted; immune, medical, reinforcing, adhesive, green electrochemical materials, biological scaffolds, and sustainable food packaging are discussed considering the size, shape, and assembly of chitin nanostructures. In summary, new perspectives for the development of sustainable advanced functional materials based on nanochitin and nanochitosan by understanding and engineering their multiscale properties are described.
Systematic Screening and Therapeutic Evaluation of Glyconanoparticles with Differential Cancer Affinities for Targeted Cancer Therapy
Authors: Whang Chang‐Hee , Hong Jungwoo , Kim Dohyeon , Ryu Hong , Jung Wonsik , Son Youngju , Keum Hyeongseop , Kim Jinjoo , Shin Hocheol , Moon Eugene , Noh Ilkoo , Lee Hee‐Seung , Jon Sangyong 
Published: May 2022

AbstractCancer‐targeting ligands used for nanomedicines have been limited mostly to antibodies, peptides, aptamers, and small molecules thus far. Here, a library of glycocalyx‐mimicking nanoparticles as a platform to enable screening and identification of cancer‐targeting nanomedicines is reported. Specifically, a library of 31 artificial glycopolymers composed of either homogeneous or heterogeneous display of five different sugar moieties (β‐glucose, β‐galactose, α‐mannose, β‐N‐acetyl glucosamine, and β‐N‐acetyl galactosamine) is converted to a library of glyconanoparticles (GlyNPs). GlyNPs optimal for targeting CT26, DU145, A549, and PC3 tumors are systematically screened and identified. The cypate‐conjugated GlyNP displaying α‐mannose and β‐N‐acetyl glucosamine show selective targeting and potent photothermal therapeutic efficacy against A549 human lung tumors. The docetaxel‐contained GlyNP displaying β‐glucose, β‐galactose, and α‐mannose demonstrate targeted chemotherapy against DU145 human prostate tumors. The results presented herein collectively demonstrate that the GlyNP library is a versatile platform enabling the identification of cancer‐targeting glyconanoparticles and suggest its potential applicability for targeting various diseased cells beyond cancer.
Light‐Controlled Fabrication of Disordered Hyperuniform Metasurfaces
Authors: Shutsko Ivan , Buchmüller Maximilian , Meudt Maik , Görrn Patrick 
Published: May 2022

AbstractDisordered hyperuniformity (DHU) is one of the most prominent manifestations of the engineered disorder, which aims to circumvent limitations commonly related to order. Considering the k‐space, isotropic DHU is characterized by an isotropic suppression of scattering for wavenumbers k approaching zero. Thereby, stealthy DHU is a particularly strong form of DHU, where scattering is even suppressed for wavenumbers 0 < k ≤ K within a circular window of radius K. Although experimental demonstrations of DHU in optical structures exist, scalable and low‐cost fabrication methods are still rare and often lack the opportunity for in‐situ control of the k‐space. Here, a novel and facile bottom‐up approach for the fabrication of DHU metasurfaces is presented. Starting with a solution‐based deposition procedure of silver nanoparticles (AgNPs) in darkness (resulting in DHU), a more extensive way of in‐situ k‐space engineering is introduced by illuminating the growing metasurface with light (resulting in stealthy DHU). While it is shown that the wavelength of incident light allows for the in‐situ control of K, its lateral momentum k∥ defines an additional design parameter. The light‐controlled growth under maximum k∥ via surface plasmon polaritons enables the experimental confirmation of the theoretically predicted phenomenon of anisotropic stealthy DHU.
Ultrathin GaAs Photovoltaic Arrays Integrated on a 1.4 µm Polymer Substrate for High Flexibility, a Lightweight Design, and High Specific Power
Authors: Cho Sungbum , Jung Dongwuk , Kim Juho , Seo Jimin , Ju Hunpyo , Lee Jongho 
Published: May 2022

AbstractLightweight ultrathin solar cells with high efficiency and reliability serve as a convenient untethered power source for new types of electronic devices, such as attachable or implantable electronics, small‐scale robots, and many others. However, the extreme mechanical properties of high‐performance solar cells and ultrathin films present challenges when handling and processing them to realize ultrathin solar cell arrays. In this paper, a highly efficient GaAs photovoltaic array integrated on an ultrathin polymer film (1.4 µm thick) is presented. Full processes, including framing, cold‐welding, epitaxial lift‐off (ELO), and microfabrication, are used to realize ultra‐flexible and lightweight GaAs photovoltaic arrays. The mechanical characteristics are analyzed via numerical and experimental methods along with demonstrations with electrically functional devices. The power‐to‐weight ratio (specific power: 5.44 W g−1) is in the highest range, even with single‐junction solar cells.
Multi‐Channel Metasurface for Versatile Wavefront and Polarization Manipulation
Authors: Shao Linda , Li Zhenfei , Zhang Zhengping , Wang Xiong , Zhu Weiren 
Published: May 2022

AbstractMetasurfaces are extensively studied for the flexible manipulation of wavefront and polarization of electromagnetic waves with significant merits such as ultra‐thin profiles and low insertion losses. However, conventional meta‐devices are usually limited by achieving only single polarization modulation, and it is challenging to achieve mixed polarization and wavefront manipulation in a single metasurface. Here, a single‐layer anisotropic metasurface for independent wavefront manipulation in multiple polarization channels is presented. The meta‐atom is composed of two orthogonal dumbbell‐shaped metal patches placed on the top of a dielectric layer with grounded plane on the bottom. The reflective phases of the two orthogonal linearly polarized waves can be independently manipulated by changing the dimensions of the dumbbell‐shaped resonator. As a result, not only the propagation phase but also the polarization state of the outgoing wave can be manipulated independently as desired. As proof of concept, a metasurface is designed for converging the reflection beams of four polarization states to specific positions for four‐focus holographic imaging. The measured results are in good agreements with simulated ones, verifying the independent wavefront manipulations with arbitrary polarization conversions.