bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinematic design of a novel Multi-legged robot with Rigid-flexible coupling grippers for asteroid exploration
Authors: Wen Qingpeng , He Jun , Gao Feng 
Published: June 2022

AbstractMulti-legged robots with rigid-flexible coupling grippers have appealing applications to asteroid exploration with the microgravity. However, these robots usually have significantly complicated structures, which leads to a great challenge for the kinematic design.This paper proposes the kinematic design method for a novel multi-legged robot with the microspine gripper. First, the structure of the multi-legged asteroid exploration robot and the microspine gripper are demonstrated. Second, four performance evaluation indices, which are used to evaluate the stiffness, velocity, motion / force transfer efficiency and gripper attachment efficiency of the robot, are derived from the kinematic model. Non-dimensional design spaces of parameters to be optimized are drawn, and performance atlases are presented in design spaces. Third, the stiffness model of the microspine is derived. In addition, the constraint condition of the restoring spring is established, and the stiffness of restoring springs are optimized using the genetic algorithm. Several experiments are conducted to verify the stiffness model of the microspine. Finally, the prototype is developed and the experimental results validates the kinematic design method.
An Apology Leading to Dystopia: Or, Why Fuelling Climate Change Is Tortious
Authors: Burgers Laura 
Published: June 2022

AbstractThis invited response commentary engages with Benoit Mayer's case comment, published in this issue of Transnational Environmental Law, on the recent landmark decision by the District Court of The Hague (The Netherlands) of May 2021 in Milieudefensie v. Royal Dutch Shell. The Court ordered the oil giant Royal Dutch Shell to reduce at least 45% of its greenhouse gas emissions by 2030 compared with 2019 levels. In this response commentary I build on and contrast Mayer's examination of how the Court arrived at this target. In doing so, I discuss the normativity of tort law compared with international law against the background of the ideas of Martti Koskenniemi. I conclude that the District Court legitimately qualified Shell's business plans as tortious. The specific reduction target is the result of civil procedural rules on evidence and the debate between the parties. In the light of this analysis, I respectfully reject Benoit Mayer's suggestion that sectoral practices should play a more significant role in determining corporate climate mitigation obligations. In my view, such an approach would be dangerously apologetic and lead to dystopian outcomes.
Bioaerosol Diversity and Ice Nucleating Particles in the North‐Western Himalayan Region
Authors: Yadav Shweta , Curtis Nathaniel P. , Venezia Rebecca E. , Tandon Ankit , Paerl Ryan W. , Petters Markus D. 
Published: June 2022

AbstractThis work presents measurements of bioaerosol diversity and ice nucleating particle (INP) concentration in total suspended particulate matter along a transect in the North‐Western Himalayan Region. Drop freezing assay was used to measure INP spectra. Flow cytometry analysis was performed to examine the abundance of autofluorescent entities in the samples. The DNA sequences were used to analyze the relative abundance, diversity, and putative functional traits of the bioaerosol community. INP concentrations varied from 1.5 × 10−3 to 5.5 L−1 air between −6°C and −24°C. Flow cytometry measurements showed a concentration stratification along the transect. Diversity measures showed that the communities are dominated by only a relatively few populations (sequence variants). Temperature and wind speed correlated with bioaerosol diversity measures. Firmicutes, Proteobacteria and Actinobacteria dominated DNA sequences obtained from samples. Populations belonging to the ice nucleating genera Pantoea and Pseudomonas were present, yet their relative abundance did not correlate with INP concentrations. Pantoea populations dominate during daytime and may be attributed to agricultural activities in the valley region with daytime anabatic winds potentially transporting the Pantoea from the valley to more remote upslope locations. Functional attributes showed dominance of metabolism (50%), followed by environmental information processing (11%), genetic information processing (9%), and cellular processes (7%). Results from this work demonstrate the importance of surface sources, land use pattern, and local meteorology for understanding atmospheric microbial communities and their link with INP concentrations in the atmosphere.
Internal Variability of All‐Sky and Clear‐Sky Surface Solar Radiation on Decadal Timescales
Authors: Chtirkova Boriana , Folini Doris , Correa Lucas Ferreira , Wild Martin 
Published: June 2022

AbstractInternal variability comprises all processes that occur within the climate system without any natural or anthropogenic forcing. Climate‐driving variables like the surface solar radiation (SSR) are shown to exhibit unforced trends (i.e., trends due to internal variability) of magnitudes comparable to the magnitude of the forced signal even on decadal timescales. We use annual mean data from 50 models participating in the preindustrial control experiment (piControl) of the Coupled Model Intercomparison Project‐Phase 6 (CMIP6) to give quantitative grid‐box specific estimates of the magnitudes of unforced trends. To characterize a trend distribution, symmetrical around 0, we use the 75th percentile of all possible values, which corresponds to a positive trend with 25% chance of occurrence. For 30‐year periods and depending on geographical location, this trend has a magnitude between 0.15 and 2.1 W m−2/decade for all‐sky and between 0.04 and 0.38 W m−2/decade for clear‐sky SSR. The corresponding area‐weighted medians are 0.69 W m−2/decade for all‐sky trends and 0.17 W m−2/decade for clear‐sky trends. The influence of internal variability is on average six times smaller in clear‐sky, compared to all‐sky SSR. The relative uncertainties in the physical representation, derived from the CMIP6 inter‐model spread, are ±32% for all‐sky and ±43% for clear‐sky SSR trends. Reasons for differences between models like horizontal resolution, aerosol handling, and the representation of atmospheric and oceanic phenomena are investigated. The results can be used in the analysis of observational time series by attributing a probability for a trend to be caused by internal variability, given its magnitude, length, and location.
Localized Excitation of Electromagnetic Ion Cyclotron Waves From Anisotropic Protons Filtered by Magnetic Dips
Authors: Yin Ze‐Fan , Zhou Xu‐Zhi , Hu Ze‐Jun , Yue Chao , Zong Qiu‐Gang , Hao Yi‐Xin , Liu Zhi‐Yang , Chen Xing‐Ran , Li Li , Fu Sui‐Yan , Funsten Herbert O. , Manweiler Jerry W. 
Published: June 2022

AbstractThe excitation of electrostatic and/or electromagnetic waves in the plasma universe is often associated with anisotropic velocity distributions of charged particles. In Earth's inner magnetosphere, this anisotropy can gradually develop as particles injected from the magnetotail drift around the Earth at different speeds depending on their energy and pitch angle. Here, we show that the perpendicular‐moving and bouncing ions can be separated more abruptly near the injection front. These pitch‐angle filters are localized magnetic dip structures formed by the diamagnetic behavior of the injected particles, which can trap perpendicular‐moving ions and allow bouncing ions to overtake. The resulting ion anisotropy facilitates the rapid generation of electromagnetic ion cyclotron (EMIC) waves, which in turn can largely reshape the Van Allen radiation belts. This scenario is examined by case and statistical observations, together with numerical simulations that reproduce most of the observational signatures, to support the causal relationship between magnetic dips, anisotropic ion distributions, and localized excitation of EMIC waves. Our study highlights the important roles of magnetic dips in the inner magnetospheric dynamics, as pitch‐angle filters of the injected ions and traveling hotspots of EMIC wave activities.
Flow goes forward and cells step backward: endothelial migration
Authors: Lee Heon-Woo , Shin Jae Hun , Simons Michael 
Published: June 2022

AbstractSystemic and pulmonary circulations constitute a complex organ that serves multiple important biological functions. Consequently, any pathological processing affecting the vasculature can have profound systemic ramifications. Endothelial and smooth muscle are the two principal cell types composing blood vessels. Critically, endothelial proliferation and migration are central to the formation and expansion of the vasculature both during embryonic development and in adult tissues. Endothelial populations are quite heterogeneous and are both vasculature type- and organ-specific. There are profound molecular, functional, and phenotypic differences between arterial, venular and capillary endothelial cells and endothelial cells in different organs. Given this endothelial cell population diversity, it has been challenging to determine the origin of endothelial cells responsible for the angiogenic expansion of the vasculature. Recent technical advances, such as precise cell fate mapping, time-lapse imaging, genome editing, and single-cell RNA sequencing, have shed new light on the role of venous endothelial cells in angiogenesis under both normal and pathological conditions. Emerging data indicate that venous endothelial cells are unique in their ability to serve as the primary source of endothelial cellular mass during both developmental and pathological angiogenesis. Here, we review recent studies that have improved our understanding of angiogenesis and suggest an updated model of this process.
Design of coherent wideband radiation process in a Nd3+-doped high entropy glass system
Authors: Zhang Linde , Zhang Jingyuan , Wang Xiang , Tao Meng , Dai Gangtao , Wu Jing , Miao Zhangwang , Han Shifei , Yu Haijuan , Lin Xuechun 
Published: June 2022

AbstractWe discover that the spatially coherent radiation within a certain frequency range can be obtained without a common nonlinear optical process. Conventionally, the emission spectra were obtained by de-exciting excited centers from real excited energy levels to the ground state. Our findings are achieved by deploying a high-entropy glass system (HEGS) doped with neodymium ions. The HEGS exhibits a much broader infrared absorption than common glass systems, which can be attributed to be high-frequency optical branch phonons or allowable multi-phonon processes caused by phonon broadening in the system. A broadened phonon-assisted wideband radiation (BPAWR) is induced if the pump laser is absorbed by the system. The subsequent low-threshold self-absorption coherence modulation (SACM) can be controlled by changing excitation wavelengths, sample size, and doping concentrations. The SACM can be red-shifted through the emission of phonons of the excited species and be blue-shifted by absorbing phonons before they are de-excited. There is a time delay up to 1.66 ns between the pump pulse and the BPAWR when measured after traveling through a 35 mm long sample, which is much longer than the Raman process. The BPAWR-SACM can amplify the centered non-absorption band with a gain up to 26.02 dB. These results reveal that the shift of the novel radiation is determined by the frequency of the non-absorption band near the absorption region, and therefore the emission shifts can be modulated by changing the absorption spectrum. When used in fiber lasers, the BPAWR-SACM process may help to achieve tunability.
Sentinel node approach to monitoring online COVID-19 misinformation
Authors: Osborne Matthew T. , Malloy Samuel S. , Nisbet Erik C. , Bond Robert M. , Tien Joseph H. 
Published: June 2022

AbstractUnderstanding how different online communities engage with COVID-19 misinformation is critical for public health response. For example, misinformation confined to a small, isolated community of users poses a different public health risk than misinformation being consumed by a large population spanning many diverse communities. Here we take a longitudinal approach that leverages tools from network science to study COVID-19 misinformation on Twitter. Our approach provides a means to examine the breadth of misinformation engagement using modest data needs and computational resources. We identify a subset of accounts from different Twitter communities discussing COVID-19, and follow these ‘sentinel nodes’ longitudinally from July 2020 to January 2021. We characterize sentinel nodes in terms of a linked domain preference score, and use a standardized similarity score to examine alignment of tweets within and between communities. We find that media preference is strongly correlated with the amount of misinformation propagated by sentinel nodes. Engagement with sensationalist misinformation topics is largely confined to a cluster of sentinel nodes that includes influential conspiracy theorist accounts. By contrast, misinformation relating to COVID-19 severity generated widespread engagement across multiple communities. Our findings indicate that misinformation downplaying COVID-19 severity is of particular concern for public health response. We conclude that the sentinel node approach can be an effective way to assess breadth and depth of online misinformation penetration.
Prevalence of pelvic floor disorders in adult women being seen in a primary care setting and associated risk factors
Authors: Kenne Kimberly A. , Wendt Linder , Brooks Jackson J. 
Published: June 2022

AbstractDetermine the prevalence of pelvic floor disorders (PFD) stratified by age, race, body mass index (BMI), and parity in adult women attending family medicine and general internal medicine clinics at an academic health system. The medical records of 25,425 adult women attending primary care clinics were queried using International Classification of Diseases-10th Revision codes (ICD-10 codes) for PFD [urinary incontinence (UI), pelvic organ prolapse (POP), and bowel dysfunction (anal incontinence (AI) and difficult defecation)]. Prevalence and odds ratios were calculated using univariate and multivariate analysis for age, race, BMI, and parity when available. Multivariate logistic regression models were used to assess the impact of age, race, BMI, and parity on the likelihood of being diagnosed with a PFD. A separate model was constructed for each of the three PFD categories (UI, POP, and bowel dysfunction) as well as a model assessing the likelihood of occurrence for any type of PFD. The percentage of women with at least one PFD was 32.0% with bowel dysfunction the most common (24.6%), followed by UI (11.1%) and POP (4.4%). 5.5% had exactly two PFD and 1.1% had all 3 categories of PFD. Older age and higher BMI were strongly and significantly associated with each of the three PFD categories, except for BMI and prolapse. Relative to White patients, Asian patients were at significantly lower risk for each category of PFD, while Black patients were at significantly lower risk for UI and POP, but at significantly greater risk for bowel dysfunction and the presence of any PFD. Higher parity was also significantly associated with pelvic organ prolapse. Using multivariate analyses, age, race, and BMI were all independently associated with PFD. PFD are highly prevalent in the primary care setting and should be screened for, especially in older and obese women. BMI may represent a modifiable risk factor.
Stripe and spot selection in cusp patterning of mammalian molar formation
Authors: Morita Wataru , Morimoto Naoki , Otsu Keishi , Miura Takashi 
Published: June 2022

AbstractTooth development is governed largely by epithelial–mesenchymal interactions and is mediated by numerous signaling pathways. This type of morphogenetic processes has been explained by reaction–diffusion systems, especially in the framework of a Turing model. Here we focus on morphological and developmental differences between upper and lower molars in mice by modeling 2D pattern formation in a Turing system. Stripe vs. spot patterns are the primary types of variation in a Turing model. We show that the complexity of the cusp cross-sections can distinguish between stripe vs. spot patterns, and mice have stripe-like upper and spot-like lower molar morphologies. Additionally, our computational modeling that incorporates empirical data on tooth germ growth traces the order of cusp formation and relative position of the cusps in upper and lower molars in mice. We further propose a hypothetical framework of developmental mechanism that could help us understand the evolution of the highly variable nature of mammalian molars associated with the acquisition of the hypocone and the increase of lophedness.
Quantum algorithm for electronic band structures with local tight-binding orbitals
Authors: Sherbert Kyle , Jayaraj Anooja , Buongiorno Nardelli Marco 
Published: June 2022

AbstractWhile the main thrust of quantum computing research in materials science is to accurately measure the classically intractable electron correlation effects due to Coulomb repulsion, designing optimal quantum algorithms for simpler problems with well-understood solutions is a useful tactic to advance our quantum “toolbox”. With this in mind, we consider the quantum calculation of a periodic system’s single-electron band structure over a path through reciprocal space. Previous efforts have used the Variational Quantum Eigensolver algorithm to solve the energy of each band, which involves numerically optimizing the parameters of a variational quantum circuit to minimize a cost function, constructed as the expectation value of a Hamiltonian operator. Traditionally, a unique Hamiltonian operator is constructed for each k-point, so that many cost functions, each with their own parameter space, must be optimized to generate a single band. Similarly, calculating higher bands than the first has traditionally involved modifying the cost function with additional overlap terms to ensure higher-energy eigenstates are orthogonal to those of lower bands. In this paper, we adopt a direct space approach, using a novel hybrid first/second-quantized qubit mapping which allows us to construct a single Hamiltonian, and a single cost-function, suitable for solving the entire electronic band structure. In contrast to previous approaches, the k-point and the band index are selected by additional parameters in our quantum circuit, rather than through modifications to the cost function. The result is a technically and conceptually simpler approach to band structure calculations on a quantum computer. Moreover, we expect that the tools developed herein will motivate new strategies for tackling highly-correlated materials beyond the grasp of classical computing.
Comparison of polysomnographic and cephalometric parameters based on positional and rapid eye movement sleep dependency in obstructive sleep apnea
Authors: Jo Jung-Hwan , Kim Sung-Hun , Jang Ji-Hee , Park Ji-Woon , Chung Jin-Woo 
Published: June 2022

AbstractThe aim of this study is to investigate the differences in polysomnographic and cephalometric features according to positional and rapid eye movement (REM) sleep dependencies in obstructive sleep apnea patients. Standard polysomnography and cephalometric analyses were performed on 133 OSA patients. The subjects were categorized into positional and non-positional, and REM-related and not-REM-related OSA groups according to positional and REM sleep dependency on severity of sleep apnea. Polysomnographic and cephalometric parameters were compared between groups. Positional and REM-related OSA patients showed significantly lower non-supine apnea–hypopnea index (AHI), non-REM (NREM) AHI and overall AHI and higher NREM oxygen saturation (SpO2) and mean SpO2 compared to non-positional and not-REM-related OSA patients, respectively. Cephalometric features between positional and non-positional OSA patients did not show any significant differences. However, REM-related OSA patients showed significantly larger inferior oral airway space and shorter perpendicular distance between mandibular plane and anterior hyoid bone and the distance between uvula and posterior nasal spine, and narrower maximum width of soft palate than not-REM-related OSA patients. Positional and REM-related OSA patients have lower severity of sleep apnea, suggesting the possibility of lower collapsibility of the upper airway. REM sleep dependency was associated with anatomical factors, while positional dependency did not show such a tendency.
Renal replacement therapy and concurrent fluconazole therapy increase linezolid-related thrombocytopenia among adult patients
Authors: Hsu Yueh-Chun , Chen Szu-Ying , Hung Yung-Jun , Huang Yu-Wei 
Published: June 2022

AbstractLinezolid has been reported to be associated with thrombocytopenia. However, limited information is available on susceptibility to thrombocytopenia after linezolid usage. We aimed to investigate the risk factors for linezolid-associated thrombocytopenia (LAT). We conducted a retrospective cohort study of patients aged ≥ 18 years who received linezolid for ≥ 5 d during hospitalization in 2019. Information was extracted from electronic medical records. Thrombocytopenia was defined as a platelet count of < 100 × 109/L or a reduction from baseline ≥ 25%. Binary logistic regression and survival analyses were used to evaluate the risk factors for LAT. A total of 98 patients were enrolled. Thrombocytopenia occurred in 53.1% patients, with a median of 9 d after initiation of linezolid. There was no significant difference in the mortality or proportion of platelet transfusions between patients with and without thrombocytopenia. A higher risk of LAT was found in patients who received renal replacement therapy (RRT) (OR 4.8 [1.4–16.4]), or concurrent fluconazole (OR 3.5 [1.2–9.8]). Patients who received RRT (8 vs. 15 d) or concurrent fluconazole (11 vs. 15 d) had a shorter median time to develop thrombocytopenia. Those who simultaneously received RRT and fluconazole had the shortest median of time (6.5 d) and the highest risk of developing thrombocytopenia (87.5%).
A pilot study of micro-CT-based whole tissue imaging (WTI) on endoscopic submucosal dissection (ESD) specimens
Authors: Sakamoto Hirotsugu , Nishimura Makoto , Teplov Alexei , Leung Galen , Ntiamoah Peter , Cesmecioglu Emine , Kawata Noboru , Ohnishi Takashi , Kareem Ibrahim , Shia Jinru , Yagi Yukako 
Published: June 2022

AbstractEndoscopic submucosal dissection can remove large superficial gastrointestinal lesions in en bloc. A detailed pathological evaluation of the resected specimen is required to assess the risk of recurrence after treatment. However, the current method of sectioning specimens to a thickness of a few millimeters does not provide information between the sections that are lost during the preparation. In this study, we have produced three-dimensional images of the entire dissected lesion for nine samples by using micro-CT imaging system. Although it was difficult to diagnose histological type on micro-CT images, it successfully evaluates the extent of the lesion and its surgical margins. Micro-CT images can depict sites that cannot be observed by the conventional pathological diagnostic process, suggesting that it may be useful to use in a complementary manner.