bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective effect of purple sweet potato leaf (Ipomoea batatas Linn Convolvulaceae) against alcohol-induced liver damage in mice
Authors: Kang Hyun , Lee Sung-Gyu 
Published: January 2022

Purpose: To investigate the hepatoprotective effect of Ipomoea batatas extract against alcohol-induced liver damage in mice.
Methods: Male C57BL/6 mice were randomly divided into 4 experimental groups (n = 10). Normal Group: The animals received distilled water 5 ml/kg for 7 days; Alcohol Group: The animals received alcohol 5 ml/kg of 40 % w/v alcohol for 7 days; Alcohol + Purple sweet potato leaf extract (PSPE) Group: PSPE 400 mg/kg was for 7 days. The animals received alcohol 5 ml/kg of 40 % w/v alcohol for 7 days; Alcohol + Hovenia dulcis Thunb extract (HDE) Group: HDE 400 mg/kg was for 7 days. To confirmed to the liver protection effect of PSPE, it was calculated, and the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), and total cholesterol (TC) in serum were detected. To evaluate changes of histological in alcohol-fed mice, liver tissue was determined by H&E staining.
Results: Blood alcohol concentration in purple sweet potato leaf extract (PSPE) 200 mg/kg and Hovenia dulcis (H. dulcis) extract (HDE) 200 mg/kg treated group significantly decreased compared to - alcohol with water treated group (p < 0.05). Serum ALT (alanine aminotransferase) and AST (aspartate aminotransferase) were markedly reduced. Liver sections in mice stained with H&E (hematoxylin and eosin) stain to displayed the physiological changes in the liver tissue. Furthermore, the results showed that inflammatory cells increased in the alcohol group compared to the normal group, but spontaneously decreased in the PSPE or HDE-treated group.
Conclusion: These results demonstrate that Ipomoea batatas may be therapeutically effective in protecting the liver from alcohol-induced hepatotoxicity and fatty liver.
Aqueous Allium sativum (garlic) extract ameliorated CdCl2- induced alterations in blood formation and spermatogenesis in albino rats
Authors: Mbegbu Edmund Chidiebere , Odo Rita Ifeoma , Ozioko Paul Tobechukwu , Awachie Mark Ebubechukwu , Nwobi Lotanna Gilbert , Obidike Ikechukwu Reginald 
Published: January 2022

Purpose: To investigate the ameliorative effect of aqueous garlic extract (AGEx) on cadmium chloride (CdCl2-induced) alterations in the blood and testicles of rats.
Methods: A total of 24 male rats (160 - 200 g), randomly assigned into 4 groups (A - D; n = 6), were used to investigate the claimed protective effect of AGEx on blood and spermatogenic tissues following CdCl2-intoxication in albino rats. The rats in Group A served as controls and were given 5 mg/mL of deionized water. Group B rats were given 300 mg/kg of AGEx. Group C rats were given 2 mg/kg of CdCl2. Rats in Group D first received 2 mg/kg of CdCl2, and 300 mg/kg of AGEx 2 h later. All treatments were done every 48 h for a period of six weeks.
Results: CdCl2 administration to group C rats reduced (p < 0.05) haematocrit value (PCV), concentration of haemoglobin (Hb), red cells count (RBC), total leucocytes count (tWBC), eosinophil, neutrophil, testicular weights and sperm reserves; but elevated (p < 0.05) lymphocytes count compared with the controls. AGEx 300 mg/kg in group D rats significantly reversed (p < 0.05) the altered parameters compared with the controls.
Conclusion: The results demonstrate that administration of aqueous Allium sativum (garlic) extract to male rats enhances spermatogenesis, and ameliorates testicular and haematological alterations induced by cadmium poisoning. Therefore, the spermatogenic principle in AGEx is a potential candidate for the clinical management of male infertility.
A study on the utilization of rice husk as a biosorbent material for Cr (VI) removal from industrial effluent
Authors: Naeem Aniqa , Batool Rida 
Published: January 2022

Purpose: To study Cr (VI) removal from waste water using chromium-resistant bacterial strains in combination with rice husk.
Methods: Two strains of Exiguobacterium sp. resistant to chromium (VI) were applied in the present work. Rice husk (RH) was used as an agricultural waste for Cr (VI) removal. The elimination of Cr from the husk was chemically facilitated using hydrochloric, sulphuric and citric acids, as well as formaldehyde and potassium dihydrogen phosphate Investigation of optimum physical factors such as pH, temperature, shaking speed and biomass concentration on Cr (VI) removal was carried out using citric acid-processed rice husk alone, and in combination of bacterial strains. Fourier transform infra-red (FTIR) spectroscopy was performed to determine the contributions of different functional groups involved in Cr (VI) binding. Scanning electron microscopy (SEM) of treated and untreated RH was also performed.
Results: Citric acid-processed RH was most effective in the removal of chromate (97.3 %). The two bacterial strains combined with rice husk proved highly efficient in Cr (VI) removal from sterile and non-sterile industrial effluents. FTIR spectra showed the involvement of esters, amines and aliphatic functional groups in Cr (VI) binding, while SEM displayed the damaging effects of Cr (VI) on the surface of RH; however, bacterial inoculation minimized the damage.
Conclusion: Exopolysaccharides from Exiguobacterium strains and citric acid-processed rice husk demonstrated high efficiency for Cr (VI) removal. Hence, RH with these bacterial strains are potential biosorbents for control of heavy metal contamination arising from industrial effluents.
Molecular docking study on columbin isolated from Tinospora cordifolia as a cholinesterase inhibitor
Authors: Onoja Joel O. , Elufioye Taiwo O. , Sherwani Zaid A. , Ul-Haq Zaheer 
Published: January 2022

Purpose: To investigate the acetylcholinesterase (AChE) inhibitory potential of columbin and also to assess its binding affinity against AChE protein.
Methods: Crystals of columbin were isolated from the ethyl acetate fraction of Tinospora cordifolia using column chromatography and its structure was determined using x-ray crystallography. Ellman colorimetric assay was used to determine the AChE inhibitory effect in vitro while molecular docking was performed using the MOE 2015.010 software. The selected protein data bank (PDB) was modeled using PDB ID: 10CE (pacific electric ray).
Results: The crystal and structure refinement data of columbin were: C20H22O6, Orthorhombic, P212121, a = 7.4951(2) Å (α = 90°), b = 11.6451(3) Å (β = 90°), c = 19.5882(5) Å (γ = 90°), V=1709.68(8) Å3, Z = 4, Density (calculated) = 1.392 Mg/m3, absorption coefficient = 0.851 mm-1, goodness-of-fit on F2 =1.091, T = 100(2) K. Columbin demonstrated good AChE inhibitory effect with half-maximal inhibitory concentration (IC50) of 1.2993 ± 0.17 mg/mL. Molecular docking data revealed that it exhibited hydrophobic and hydrogen bonding interactions with the surrounding residues, and this accelerated complexation between the ligands and the active site of the enzyme.
Conclusion: Columbin may be useful in the management of neurodegenerative conditions such as Alzheimer’s disease.
Cytotoxic effect of Leurius quinquestratus (scorpion) venom in different human cancer cell lines in vitro
Authors: Salama Wesam M. , El-Naggar Sabry A. 
Published: January 2022

Purpose: In this study, the cytotoxicity of scorpion Leurius quinquestratus crude venom (LQCV) was evaluated in vitro in selected human cancer cell lines.
Methods: Breast (MCF-7), hepatocellular (HepG-2), colon (CaCo-2), cervix (HeLa) and alveolar (A-549) adenocarcinoma cell lines were tested. MTT assay and median inhibition concentration (IC50), apoptotic assay, caspase 3, P53, Bcl-2 proteins and cell cycle were determined.
Results: 24 hrs post-treatment, CaCo-2 represented the most sensitive cell line (IC50 of 4.12 μg/mL). Due to the exposure to 1/10 IC50 of LQCV, the percentage of the apoptotic cells, caspase 3, and P53 proteins were increased significantly (P<0.05) while Bcl-2 was decreased in comparison to untreated cells. Treatment with LQCV induced cell cycle arrest at G1 and G2/M phases.
Conclusion: LQCV displays potent cytotoxicity against selected human cell lines in vitro. Thus, the material could become a potent agent for the management of some cancers.
Effect of styrene oxide and diethyl maleate on expression of cytochrome P450 family 1 and glutathione store in mouse liver
Authors: Chatuphonprasert Waranya , Jarukamjorn Kanokwan 
Published: January 2022

Purpose: To determine the effect of the glutathione (GSH) suppressors styrene oxide (SO) and diethyl maleate (DEM) on the hepatic expression of cytochrome P450 family 1 (Cyp1) isoforms that are related to carcinogenesis including Cyp1a1, Cyp1a2, and Cyp1b1.
Methods: Seven-week-old ICR mice were intraperitoneally injected with SO (150 and 300 mg/kg/day), DEM (175 and 350 mg/kg/day), or N-acetylcysteine (NAC; 300 and 600 mg/kg/day) for 7, 14, or 28 days. Plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, hepatic Cyp1 expression, total glutathione, reduced glutathione (GSH), and oxidized glutathione (GSSG) were determined.
Results: ALT and AST levels were markedly increased by SO and DEM while GSH/GSSG ratio was decreased by SO in all treatments (p < 0.05), while high dose (350 mg/kg/day) DEM significantly suppressed GSH/GSSG ratio at 28 days (p < 0.05). The expressions of Cyp1a1, Cyp1a2, and Cyp1b1 were induced by SO and DEM, corresponding with induction of ethoxy/methoxy-resorufin O- dealkylase activities.
Conclusion: The Cyp1 family metabolizes procarcinogens to carcinogenic DNA adducts; exposure to the industrial solvents, SO and DEM, raises the risk of carcinogenesis via GSH depletion coupled with Cyp1 induction.
Development and validation of a novel chemiluminescent immunoassay for diagnosing primary aldosteronism
Authors: Ge Li , Ma Jian-Jun , Wu Meng-Ru , Jia Yun , Xu Ya-Li , Xu Hong-Feng 
Published: January 2022

Purpose: To compare the diagnostic accuracy of plasma aldosterone concentration (PAC), plasma renin activity (PRA) and aldosterone-to-renin ratio (ARR) in primary aldosteronism (PA) using radioimmunoassay (RIA) and chemiluminescence immunoassay (CLIA) methods.
Methods: Both RIA and CLIA were used to analyze the PAC, PRA and ARR with subjects in standing or supine position, before and after a saline infusion test (SIT). The correlation between RIA and CLIA was measured by regression analysis. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic accuracy by RIA and CLIA.
Results: A positive correlation was found between PAC and PRA after SIT using RIA and CLIA (0.1745 and 0.3085, respectively). A positive correlation was found between the PAC and PRA in standing and supine position using RIA and CLIA (0.3979 vs 0.2399 and 0.1885 vs 0.4032, respectively). There was no obvious difference in AUCs of PAC, PRA, and ARR between RIA and CLIA (PAC: 0.91 vs. 0.89; PRA: 0.88 vs. 0.87; ARR: 0.93 vs. 0.92). In standing posture, the AUCs of PAC, PRA and ARR using RIA were 0.63, 0.72 and 0.78, respectively, and the results of CLIA were 0.65, 0.75 and 0.82, respectively. In supine posture, the AUC of PAC, PRA and ARR using RIA was 0.65, 0.68 and 0.71, respectively, and the results of CLIA were 0.68, 0.70 and 0.79, respectively.
Conclusion: Chemiluminescent assay is reliable for diagnosis of PA when compared with radioimmunoassay.
Future ethical implications and potential health consequences of nanotechnology research in Jordan: A scientometric analysis
Authors: Akkam Yazan , Khatatbeh Moawiah 
Published: January 2022

Purpose: To evaluate the implanted legislation and regulations in Jordan, in order to minimize nanotechnology research-related health concerns.
Methods: In the first part, all nanotechnology published research in Scopus database and the Jordanian National Database for Researchers were mined. The growth in nanotechnology research was analyzed by calculating the relative growth rate (RGR), doubling time (DT), and compound annual growth rate (CAGR). Thereafter, the results were compared to global preferences. Furthermore, this research explored all possible factors that may influence decision-makers and health policies in Jordan.
Results: Data analysis showed that the quantity of nanotechnology research in Jordan is exponentially increasing with RGR (1.96), DT (0.37), and CAGR (33 %) very close to the figures obtained worldwide. The trend line analysis (R2 = 0.9638) expected that more than 65 % of nanotechnology research will be produced within the next 5 years. Moreover, no legislation has been adapted in Jordan to regulate nanotechnology research and industry.
Conclusions: Adopting nanotechnology without having any corresponding legislation constitutes a violation of the ethical codes of research, and ignorance of public safety. Moreover, the research suggests a set of steps to organize the crafting of nanotechnology and research in Jordan, and other similar contexts in developing countries.
Withaferin A downregulates COX-2/NF-κB signaling and modulates MMP-2/9 in experimental endometriosis
Authors: Dan Wang , Yiling Jiang , Chun Li , Jing Fan , Huimin Wang , Xiaoxin Yang 
Published: January 2022

Purpose: To study the effect of withaferin A on an experimentally-induced endometriosis (EM) model.
Methods: Female Sprague-Dawley rats were induced EM by implantation of autologous endometrium. Rats in the treatment group were administered withaferin A orally for 30 days. A separate group of rats that was administered gestrinone (GTN) served as positive control.
Results: Withaferin A treatment reduced the spherical volume of the ecto-uterine tissue was following five weeks after implantation. Histological analysis revealed regression of the lesions and restoration of normal architecture. Withaferin A effectively down-regulated the expressions and activities of matrix metalloproteinases (MMPs) 2 and 9 in the ectopic endometrium. The activities of MMPs-2 and 9 significantly (p<0.05) decreased from 1.79- and 1.65-fold to 1.08- and 1.1-fold, respectively. The EM- induced up-regulation of NF-κB/COX-2 signaling was down-regulated by withaferin A. The levels of Cox-2 decreased significantly (p < 0.05) from 198 % in EM control rats to 122.7 % in 150 mg withaferin A treated EM-induced rats. The increased levels of major inflammatory mediators nitric oxide (NO), TNF-α, Interleukins (IL) - IL-1β and IL-6, markedly (p < 0.05) were reduced by withaferin A treatment, when compared to EM control group.
Conclusion: Withaferin A effectively suppresses the proliferation of lesions and modulates the immune responses-associated expressions of COX-2, NF-κB and matrix metalloproteinases (MMPs), viz, MMP- 2 and MMP-9
Improving Upper Extremity Strength, Function, and Trunk Stability Using Wide-Pulse Functional Electrical Stimulation in Combination With Functional Task-Specific Practice
Authors: Tefertiller Candace , Bartelt Patricia , Stobelaar Maureen , Charlifue Susie , Sevigny Mitch , Vande Griend Eric , Rozwod Meghan 
Published: January 2022

Objectives
To evaluate upper extremity (UE) function, strength, and dynamic sitting balance in individuals with spinal cord injury (SCI) who received an intensive outpatient therapy program focused on UE training augmented with wide pulse/high frequency functional electrical stimulation (WPHF-FES).

Methods
This prospective case series was conducted in an outpatient (OP) clinic in an SCI-specific rehabilitation hospital. Participants were a convenience sample (N = 50) of individuals with tetraplegia receiving OP therapy focused on UE recovery. Individuals participated in 60 minutes of UE functional task-specific practice (FTP) in combination with WPHF-FES 5 times/week for an average of 72 sessions. The primary outcome for this analysis was the Capabilities of Upper Extremity Test (CUE-T). Secondary outcomes include UE motor score (UEMS) and the modified functional reach (MFR).

Results
Fifty individuals (13 motor complete; 37 motor incomplete SCI) completed an OP UE training program incorporating WPHF-FES and were included in this analysis. On average, participants demonstrated significant improvements in the total CUE-T score of 14.1 (SD = 10.0, p &lt; .0001) points; significant changes were also noted in UEMS and MFR, improving an average of 4.6 (SD = 5.2, p &lt; .0001) points and 13.6 (SD = 15.8, p &lt; .0001) cm, respectively.

Conclusion
Individuals with tetraplegia demonstrated significant improvements in UE strength, function, and dynamic sitting trunk balance after receiving UE training augmented with WPHF-FES. Future comparative effectiveness studies need to be completed to guide efficacious treatment interventions in OP therapy.
NEOLIBERALISMO E CRIMINALIZAÇÃO DA POBREZA NO BRASIL
Authors: Da Silva Andrade Patrícia , Suassuna Vaz Lira Terçalia 
Published: January 2022

: O presente artigo visa apontar algumas considerações sobre a criminalização da pobreza, no contexto de crise do capital, enquanto uma estratégia neoliberal do Estado Penal na busca de soluções para a gestão da pobreza, com o objetivo de conter os conflitos sociais provenientes das desigualdades inerentes ao modo de produção e reprodução do capital. Com o processo de diminuição do Estado social, ocorre a ampliação do Estado penal, o que acarreta a disseminação de uma lógica de criminalização da pobreza e da judicialização dos problemas sociais. Estes fatores, por sua vez, colocam a população não amparada pelo Estado, cada vez mais no patamar de responsáveis pelo seu próprio bem estar social. A pesquisa, metodologicamente, recorreu a revisão bibliográfica e apontou um cenário de retrocessos na efetivação das políticas públicas, as quais são transformadas em políticas pontuais comprometidas essencialmente com os interesses da classe dominante.
ATENDIMENTOS REMOTOS, VIOLAÇÃO DE DIREITOS E A SOBRECARGA DA ASSISTÊNCIA SOCIAL
Authors: Alexandre Duarte Luana 
Published: January 2022

Com o advento da pandemia de Covid-19 e a decorrente necessidade de se ofertar modalidades de atendimento remoto no âmbito dos serviços e das políticas públicas, agudizou-se uma demanda que já vinha se difundindo no atendimento técnico realizado na Assistência Social, de mediação para cadastros, agendamentos, consultas de processos, requerimentos de benefícios e atendimentos virtuais, das mais diversas políticas e serviços públicos, por pessoas que não possuem celular/computador/internet e/ou que têm dificuldade em compreender e executar sozinhas tais procedimentos. Este artigo pretende esclarecer porque estas demandas, que em alguns casos já existiam antes da pandemia, não cabem à Assistência Social, bem como denunciar essa faceta da violação de direitos do cidadão, especialmente do “cidadão-pobre”, que tem seu acesso às demais políticas e serviços públicos dificultado na era digital. Para tanto, propõe um levantamento documental e bibliográfico, e uma reflexão fundamentada na perspectiva teórico-metodológica marxista de análise das relações sociais. A bibliografia escolhida e sua interlocução mais ou menos direta com a problemática trazida pelo artigo possibilitou elucidar contradições, a relação entre o particular e o universal, bem como contextualizar o cenário de espoliação mais amplo da classe trabalhadora que se desenha na contemporaneidade.
Palavras-chave: Serviços Públicos Digitais. Violação de Direitos. Assistência Social.
PŘEHLED VÝVOJE EMISNÍCH STANDARDŮ PRO OMEZENÍ ZNEČIŠŤOVÁNÍ OVZDUŠÍ NESILNIČNÍMI MOBILNÍMI STROJI
Authors: Verner Jan 
Published: January 2022

Každý stroj poháněný spalovacím motorem má vliv na obecnou úroveň antropogenního znečištění. Tyto pohony podléhají různým předpisům omezujícím jejich emise pro provozní podmínky a aplikace. Jednou ze skupin takových strojů popsaných v evropských či amerických předpisech jsou nesilniční mobilní stroje. Jelikož není problematika v českých odborných časopisech souhrnně uvedena a zahraniční literatura obsahuje jen málo informací, je cílem tohoto příspěvku prezentace stávajících legislativních regulací týkajících se limitů emisí škodlivých látek z výfukových plynů, které jsou vytvářeny vznětovými spalovacími motory nesilničních mobilních strojů, speciálně hnacími drážními vozidly.
Estudio de rendimiento energético de bioceldas solares
Authors: Hernández Ruben Téllez , Cruz Fermín Tenorio , Cortes Erik Juarez , Camacho Alberto Vera 
Published: January 2022

La búsqueda de fuentes de energía es uno de los retos más grandes de la ciencia e ingeniería la, cual investiga para evitar de destruir nuestro planeta utilizando energéticos que contaminen el medio ambiente. Una de las más comunes es la energía solar, basada en células fotovoltaicas que utilizan las cargas opuestas producidas por la energía lumínica para crear un campo eléctrico y, con él, generar corriente. En breve, el consumo de esta fuente de energía ha ido aumentando a nivel mundial, y la investigación de un modo de potenciar el método no ha parado ni un solo momento, así en la naturaleza quienes más dominan en el uso la luz del sol para obtener energía son las plantas y algunas bacterias, por lo que si no podemos ser mejores que ellas tan solo es mejor imitarlas y aprovechar sus recursos como fuentes de modelado en el aprovechamiento de esa energía, y en lo posterior aprovechar esa energía solar. En el futuro el mejor aprovechamiento de la energía solar y mayor eficiencia energética en el uso de bioceldas solares, es el objetivo de este estudio, aprovechar la energía lumínica y convertirla en útil energía eléctrica y aprovechar al máximo ese potencial para cubrir nuestras necesidades de energía mundial.
MIÉRT ELŐNYÖS A DUÁLIS KÉPZÉS A RÉSZTVEVŐK SZÁMÁRA?
Authors: Toth Katalin 
Published: January 2022

Magyarországon 2015-ben intézményesített formában bevezetésre került a duális képzés. A duális képzés a munkaerőpiac igényeire adott válasz, mely bevezetése óta egyre népszerűbb. A képzés összetett, többszereplős, így komoly feladatot jelent annak hatékony működtetése. Már most láthatóak azok a társadalmi, gazdasági folyamatok, melyek a képzés bevezetésének köszönhetően indultak el.
A cikk a duális képzés előzményeit, jellegzetességeit, előnyeit és nehézségeit szándékozik bemutatni, a témában fellelhető szakirodalomra támaszkodva.
REPRESENTASI KECANTIKAN DALAM MEDIA SOSIAL (ANALISIS SEMIOTIKA ROLAND BARTHES PADA VIDEO TUTORIAL MAKEUP BEAUTY VLOGGER TASYA FARASYA DI YOUTUBE)
Authors: Yuwita Nurma , Ayu Nurdiana  
Published: January 2022

Persoalan yang dikaji dalam skripsi ini, yaitu: (1) bagaimana representasi kecantikan pada video tutorial make-up Beauty Vlogger Tasya Farasya di Youtube dengan analisis semiotika Roland Barthes? Untuk mengungkap masalah tersebut secara menyeluruh dan mendalam, penelitian ini menggunakan metode kualitatif deskriptif dengan analisis semiotika Roland Barthes. Peneliti menggunakan jenis penelitian deskriptif karena peneliti menafsirkan representasi kecantikan pada video tutorial tersebut. Dari hasil penelitian ini ditemukan bahwa kecantikan adalah (1) ketika memakai foundation, (2)memakai concealer dibagian bawah mata, (3) memakai blush on pada pipi,(4) memakai bedak, (5)memakai highlight&contour pada bagian wajah,(6) memakai eye shadow dibagian mata, (7)memakai eye liner dibagial kelopak mata, (8)mengukir pensil alis dengan cantik, (9)memakai maskara pada bulumata, (10)mengoles lipstick pada bibir. Berdasarkan hasil penelitian ini beberapa saran yang dapat dijadikan bahan pertimbangan antara lain: (1) Bagi masyarakat, Supaya lebih bijak dan lebih cermat berpikir bahwa terkadang tidak semua kata “cantik” itu harus memakai dengan make-up. (2) Bagi akademis, dapat menambah pengetahuan tentang makna-makna yang berkenaan video konten kecantikan di youtube, agar lebih mudah memaknai makna cantik yang sesungguhnya.