bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genus Acronychia: An Extensive Review on Phytochemistry and Pharmacological
Activities
Authors: Son Ninh The 
Published: October 2022

Background:
Acronychia is a genus of the medicinal plants that was used traditionally to treat various ailments such as cough, asthma, sores, ulcers, itchy skin, fever, and rheumatism. Acronychia plants have a wide range of distribution, but they are mostly native to India, Siri Lanka, Australia, and Indochina. Since the 1950s Acronychia plants have been extensively used in phytochemical research and pharmacological examinations.

Objective:
The goal of this study is to structurally compile almost secondary metabolites from the title plants, as well as coverage of full information on their biomedical actions.

Conclusion:
Phytochemical profile of this genus is associated with the appearances of various chemical
classes, including principal compounds type acetophloroglucinols and alkaloids, as well as other
types coumarins, mono-phenols, flavonoids, phytosterols, lignans, xanthenes, and tocopherols. More
than one hundred thirty secondary metabolites have been isolated. Naturally occurring acetophloroglucinols
represented in both monomers and dimers, and most of them were new in nature.
Phytochemical research based on GC-MS identification showed that Acronychia plants should be
suitable for the cosmeceutical field and food chemistry due to the high content of volatiles.
Acronychia extracts are safe in use, and they are increasingly exploited within pharmacological assays.
In agreement with traditional properties, crude plant extracts, fractions, and their isolated compounds
are well-known for antimicrobial, antioxidative, antiinflammatory, antiprotozal, antiarrhythmic,
antinociceptive, antihistamine, and allelopathic activities, especially in terms of cytotoxicity. A
sustainable use program should be established to aid the further studies of these medicinal plants.
Acute Mesenteric Ischemia: The Diagnostic Value of QT Parameters and their
Relationship with CT Findings
Authors: Alan Bircan , Alan Sait , Gurel Safiye , Inanir Mehmet , Acar Emrah , Donmez Ibrahim , Kalaycioglu Oya 
Published: October 2022

Background:
One of the greatest challenges in the diagnosis of acute mesenteric ischemia (AMI) is the lack of specific laboratory tests that support multidetector computed tomography (CT). Our aim is to investigate the diagnostic value of electrocardiographic QT parameters in AMI and their relationship with CT findings.

Materials and Methods:
Patients who were admitted to the emergency department with abdominal pain were recruited retrospectively from the hospital information system . Grouping was carried out on the basis of AMI(n=78) and non-AMI (n=78). In both groups, the corrected QT (QTc) and QT dispersion (QTD) were measured on electrocardiographs, and the qualitative and quantitative CT findings were evaluated on CT examinations.

Results:
The QTc and QTD values were higher in the AMI group. The median QTc values were 456.16 (IQR: 422.88-483.16) for the AMI group and
388.83 (IQR: 359.74-415.83) for the control group (p<0.001), and the median QTD values were 58 (IQR: 50.3-68.25) for the AMI group and 46
(IQR: 42-50) for the control group (p<0.001).

:
In the CT analysis, the QTc values were significantly higher among AMI patients, with images of paper-thin bowel walls and the absence of bowel
wall enhancement (p=0.042 and p=0.042, respectively). Meanwhile, the QTD values were significantly higher among patients with venous
pneumatosis findings on CT (p=0.005). In the regression analysis, a significant relationship was found between the QT parameters and AMI
(p<0.001). For QTc, an AUC of 0.903 (95% CI: 0.857-0.950, p<0.001), a sensitivity of 80.8%, and a specificity of 82.3% were found. For QTD, an
AUC of 0.821 (95% CI: 0.753-0.889, p<0.001), a sensitivity of 73.1%, and a specificity of 82.3% were found.

Conclusion:
We found the QTc and QTD values to be significantly higher among AMI patients. Furthermore, we found a significant relationship between the CT findings and QTc and QTD as well as a significant relationship between survival and QTc in the AMI group.
Ellagic Acid Prevents Oxidative Stress and Memory Deficits in a Rat Model of Scopolamine-induced Alzheimer's Disease
Authors: Rajabian Arezoo , Assaran Amir Hossein , Akbarian Mahsan , Amirahmadi Sabiheh , Salmani Hossein , Shirzad Shima , Hosseini Mahmoud , Beheshti Farimah 
Published: October 2022

Background:
Ellagic acid (EA) has various pharmacological effects such as anti-inflammatory and anti-oxidant effects.

Objective:
This study aimed to investigate the effects EA on learning and memory dysfunction as well as oxidative stress in scopolamine-induced amnesic rats.

Methods:
The studied rats were treated according to the following protocol: Control (group 1) and scopolamine (group 2) groups received saline (intraperitoneal injection (i.p.)) while the treatment groups (group 3-5) were given EA (25, 50, and 100 mg/kg, i.p.) for 3 weeks. Thereafter, their behavioral performance was evaluated using Morris water maze (MWM) and passive avoidance (PA) tasks. Notably, scopolamine was injected (into groups II-V at a dose of 2 mg/kg, i.p.) before conducting the tasks. Finally, the oxidative stress indicators in the brain were measured.

Results:
EA reduced the escape latencies and distances during learning phase of MWM. The results of probe trials also indicated that EA improved memory retrieval and helped the animals recall the platform. Moreover, EA increased delay and light time, while decreasing the frequency of entries to the dark area of PA. In the EA-treated groups, the level of malondialdehyde was decreased, while the levels of total thiol groups, superoxide dismutase, and catalase were increased.

Conclusion:
EA prevented the negative effects of scopolamine on learning and memory which is probably mediated via modulating oxidative stress. Hence, EA could be considered as a potential alternative therapy in dementia.
Acrophialophora fusispora as an Agent of Mycotic Keratitis: A Case
Report and Review of Literature
Authors: Singla Nidhi , Sharma Swati , Gulati Neelam , Arya Sudesh Kumar , Chander Jagdish 
Published: October 2022

Background:
Acrophialophora species is an infrequent human opportunistic pathogen. It is widely distributed in temperate as well as tropical regions. Hereby, we are presenting a rare case of fungal keratitis caused by A. fusispora.

Case Report:
A 26 year, Male, driver, presented with pain, watering, redness, whitish discoloration and blurring of vision in left eye for the last 3-4 days. On examination, he had a dry looking corneal ulcer with infiltration and satellite lesions. Corneal scrapings were positive for septate fungal hyphae by Gram staining and KOH mount. After five days, growth observed was presumptively identified to be genus Acrophialophora and finally identified to be Acrophialophora fusispora by genetic sequencing. The patient failed to respond medically and was planned for therapeutic keratoplasty.

Discussion:
Till date four cases of mycotic keratitis due to Acrophialophora have been described. Amongst which one case was associated with immunocompromised state. Two of the cases resolved medically while two required therapeutic keratoplasty indicating possible strong pathogenicity to eye.

Conclusion:
As Acrophialophora seems to have a predilection for eye infections, an early diagnosis with timely appropriate treatment is the best way to restore normal vision of patient.
The Natural Neuroprotective Compounds Used in the 6-Hydroxydopamine-
Induced Parkinson’s Disease in Zebrafish: The Current
Applications and Perspectives
Authors: Abidar Sara , Hritcu Lucian , Nhiri Mohamed 
Published: October 2022

Background and Objective:
Parkinson's disease (PD) is a neurodegenerative disorder characterized
by the degeneration of the dopaminergic neurons in the substantia nigra pars compacta, resulting
in the loss of dopamine in the striatum, leading thus to the PD classic movement symptoms:
resting tremor, rigidity, and bradykinesia/akinesia. Furthermore, Levodopa’s efficacy declines with
long-term use, generating serious motor complications. Neuroprotection implies the use of different
agents exhibiting various neuroprotective strategies to prevent brain degeneration and neuron loss. The
present review aims to summarize and analyze the natural neuroprotective compounds that have been
tested against PD induced by the 6-hydroxydopamine (6-OHDA) in zebrafish.

Results:
The current study collected 23 different natural substances, divided into five distinct categories,
namely herbal extracts, herbal formulations, bioactive compounds, marine products, and marine
extracts. They modulate various signaling pathways involved in PD pathogenesis and exhibit specific
activities such as an anxiolytic profile, improving locomotor impairment, restoring memory troubles,
preventing DNA loss, inhibiting acetylcholinesterase, reducing lipid peroxidation and antiinflammatory
activity, and enhancing the brain antioxidant enzymes.

Conclusion and Perspectives:
This review discusses the most promising natural neuroprotective compounds
that have been evaluated for their potential efficiency on the 6-OHDA-induced lesions in the
zebrafish model. These natural substances deserve further consideration for determination of their optimum
concentrations, bioavailability, and their ability to cross the blood-brain-barrier to exert their
effects on PD. Furthermore, a complete understanding of the molecular mechanisms involved in PD
and larger epidemiologic and randomized clinical trials in humans is also required.
Caring for Transgender Youth with Eating Disorders in a Day
Treatment Program
Authors: Salvatore Lauren , Dancyger Ida , Shadianloo Shervin , Fornari Victor 
Published: October 2022

Background:
The treatment of transgender youth with an eating disorder presents particular considerations due to the unique combination of body dissatisfaction, drive for thinness, malnutrition coupled with the evolving gender identity in the midst of biological and physical changes. At this time, public awareness, societal acknowledgment and legislative initiatives have led to wider acceptance of Lesbian, Gay, Bi-sexual and Transgender rights. However, at the same time, transgender youth are at increased risk for mental health problems, including eating disorders.

Objective:
To describe two cases of trans adolescents with anorexia nervosa treated in a day treatment program.

Methods:
In this paper, the two clinical vignettes of transgender adolescent with anorexia nervosa will be discussed. The focused care included specific attention to the initial disclosure of gender identity in a safe space, name and pronoun preferences as well as wardrobe and hair style changes. In addition, treatment focused on the reduction of social anxiety around meal consumption with special attention given to the impact of weight on the development of secondary sex characteristics. Themes of identity, rejection and secrecy were explored.

Conclusion:
In summary, the treatment of transgender youth with anorexia nervosa is more complex than treatment of cis gender youth. Additional issues, such as hormonal treatments, the development of secondary sexual characteristics as well as social and cultural factors can exacerbate eating disorder symptoms. Treatment should focus on understanding the etiology and the trajectory of the disorder within this lens.
The Impact of SSRI Use on the Clinical Outcome and Prognosis of
COVID-19 Patients: A Single-Center Prospective Study
Authors: Safa Mitra , Ziaee Seyed Ali , Moniri Afshin , Boroujerdi Fatemeh Ghassem , Zadeh Farzaneh Haji , Soheili Amirali , Afaghi Siamak , Rahimi Fatemeh Sadat , Zadeh Ardekani Bamdad Mirab 
Published: October 2022

Background:
Recent studies have found a link between the usage of selective serotonin reuptake inhibitors (SSRIs) and a lower mortality rate in COVID-19 cases.

Objective:
The goal of current research was evaluating the effectiveness of SSRI drugs on improvement of COVID-19 patients.

Methods:
This prospective case-control study, compared SSRI-treated patients with matched control patients not treated with SSRIs at Masih Daneshvari Hospital on a population of 350 patients diagnosed with COVID-19 from March 15th 2021 to March 16th 2022.

Results:
ICU admission rates were significantly more in the control group than in the case group (44.8% vs. 25.9%; p-value=0.0002; Odds Ratio (OR)= 2.32). Intubation was reported for more cases in the control group than the case group (26.7% vs. 11.4%; p-value=0.0002; OR=2.84). Mortality rate was found to be significantly more in the control group than the case group (23.0% vs. 10.8%; p-value=0.0002; OR=2.46). Furthermore, the subgroup analyses on Fluvoxamine and Sertraline showed that Hospitalization period, ICU admission rates, and intubation were all reported to be significantly smaller in each case subgroups as against the control group.

Conclusion:
Our assessments underlined the potential efficacy of SSRIs in improving COVID-19 patients’ prognosis, since the use of SSRIs were shown to be associated with shorter hospital stay and ICU stay, lower ICU admission rates and intubation rates, and ultimately decreased mortality rates.
Electrospun Nanofiber Composite for Levofloxacin in Ocular Drug
Delivery
Authors: Sangole Shrinivas , Salave Sagar , Rana Dhwani , Shah Srushti , Medhe Tanvi Pawar , Benival Derajram 
Published: October 2022

Background:
Levofloxacin is available in the form of an eye drop solution for the
treatment of ocular bacterial infection and inflammatory diseases. Below 5% of the drug gets absorbed after topical application of eye drop. The major portion of administered drug either comes
out from the eye or drains out by the nasolacrimal duct, which results in poor bioavailability.

Objective:
We aim to prepare a polymeric ocular insert containing levofloxacin as a drug prepared
by the electrospinning technique that can release the drug for an extended duration.

Methods:
Electrospun nanofiber sheets were prepared using hydroxypropyl cellulose and polycaprolactone polymer. Drug content was analysed by HPLC. Nanosheet was examined by DSC
and FTIR for compatibility study. Optimized nanosheet was further studied for weight uniformity,
swellability index, surface pH, and in-vitro drug release. The morphology of the prepared sheets
was examined using optical microscopy and SEM analysis.

Results:
The uniform, beadles, and continuous nanofibers were obtained by electrospinning. From
the DSC and FTIR data, it was proved that drugs and polymers were compatible in nanosheets.
Drug content and % drug loading in the electrospun sheets were found to be 101.70% and 4.33%,
respectively. The thickness of the sheets was around 0.31± 0.04 mm and the swelling index was
observed at 566.66% after 30 min. The surface pH of the ocular insert was found to be 6.81 and
6.83 after 30 min and 24 h., respectively. In-vitro drug release showed that 99% of the drug was
released in 24 h

Conclusion:
A prepared nanocomposite sheet can be used for the sustained drug delivery of
levofloxacin in ocular eye disease, reducing the dosing frequency and improving patient compliance.
Anti-COVID-19 Traditional Chinese Medicine Database
Authors: Zhou Jinming , Chen Chao , Zhang Rongyu , Wei Wancheng 
Published: October 2022

Background:
Novel coronavirus pneumonia COVID-19 has become a serious threat to human
health. Traditional Chinese Medicine (TCM) has a good clinical effect in the treatment of COVID-19,
with a high effective rate and a low rate of turning to the serious stage.

Objective:
We generated the web-accessed anti-COVID-19 TCM database to provide the anti-COVID-19
TCM information to develop effective drugs for the treatment of COVID-19.

Methods:
Herein, we collected these prescriptions data by querying the CNKI and Wanfang Chinese databases,
the clinical guidance for COVID-19 pneumonia diagnosis and treatment, and further set up the
web-accessible anti-COVID-19 TCM database.

Results:
Altogether, 293 different prescriptions are applied in four different COVID-19 stages of treatment,
and the prevention of COVID-19 is composed of 452 TCM components.

Conclusion:
The database provides comprehensive information for anti-COVID TCM and thus would
help to investigate novel ways to develop new anti-COVID-19 agents.
Word equivalence of the bilingual storybook translation
Authors: Amalia Ila 
Published: October 2022

Equivalence is a very important factor and an inseparable part of a series of translation activities. Equivalence occurs when the linguistic units in the source language have the same meaning when it is transferred into the target language. This study aimed to describe (1) the translation difficulties in achieving word-level equivalence, and (2) the strategies in achieving word-level equivalence. The data sources were excerpts of words, phrases, and sentences from the bilingual storybook with the title Qonita dan Peternak Ayam - Qonita and The Chicken Breeder written by Setiawan G. Sasongko. Document observation was used as the data collection technique, meanwhile content analysis was used as the data analysis technique. The analysis of strategies and difficulties in translation were based on the theory of Baker (2011) and Newmark (1991). The results of the study indicated that the translation of bilingual storybook mostly used a word-by-word and free translation strategy to achieve word-level equivalence. The results of the analysis also revealed several types of difficulties in achieving the word-level equivalence. Those were differences in word forms, differences in the purpose and level of use of certain forms, cultural special concepts, and the absence of subordinate elements in the source language. Meanwhile, the strategies to overcome the difficulties found in achieving word-level equivalence were to eliminate certain words and to utilize more general words. Keywords: translation process, word equivalence, translation strategy, word translation, free translation
The symbol of the apes power in the Kembang Dewa Retna play
Authors: Darmoko Darmoko , Christian Briliyandi Pramaditra Raden Mas 
Published: October 2022

Purwa shadow puppets are divided into several ages, namely myths about the gods, Lokapala, Arjunasasrabahu, Ramayana, and Mahabharata. The Kembang Dewa Retna play is based on a story originating from the Ramayana period. The battle for primacy and outrage in the story is built through the plays performed by the dalang. This study discusses the relationship between symbols, power, and supernatural powers in the wayang kulit play of the Ramayana era entitled Kembang Dewa Retna by Ki Manteb Soedharsono. Flower of Dewa Retna as a manifestation of the power of the monkey which is manifested through Kapi Pramuja. This study aims to explain the struggle of ape forces against giant forces. This study uses an objective approach, qualitative descriptive method, and the theoretical conceptual framework of Javanese ethics from Franz Magnis Suseno. The results of this study indicate that the Flower of Dewa Retna is a symbol of the power of apes who have magical powers and struggle against anger. The power of the Kembang Dewa Retna bestowed by the gods to uphold virtue, truth, and justice.Keywords: symbol, power, magic, wayang kulit purwa, Javanese
Positioning idealism with the power of Waspada newspaper review of the van Leeuwen theory
Authors: Pohan Jusrin Efendi 
Published: October 2022

This research is motivated by the problem of conspiracy between idealism and power in the context of critical discourse analysis studies. The domination of power makes idealism lose its resonance as a pillar of truth and justice which is marked by resistance and trust from its readers. This needs to be studied academically with The van Leeuwen's theory in the perspective of critical discourse analysis. The purpose of this study is to photograph the relationship between power and idealism, marginalization, and conspiracies of the mass media and their readers. In Theo van Leeuwen's theory, a problem is analyzed by exclusion and inclusion based on ideology. This type of research is a qualitative research that describes descriptively the problems in the Nusantara column in the North Sumatran Waspada newspaper. The source of the research data was obtained from the Nusantara column in the Waspada newspaper by analyzing the items per sentence according to Theo van Leeuwen's theory. Keywords: Idealism, Power, Critical Discourse Analysis
IDEOLOGICAL REPRESENTATION THROUGH NOUNS IN THE QUESTION OF RED AND ITS SELF-TRANSLATION AMBA
Authors: Nugroho Andy Bayu , Huntley Myrna Laksman , Hidayat Rahayu Surtiati 
Published: October 2022

Literary translation are often faced with problems of equivalence, faithfulness, accuracy, and naturalness. This becomes more complex because the author can choose between many options. Therefore, the author’s choice of style has roles in representing his ideology. This study discusses literary translation by the author herself. This study aims at explaining whether the case of self-translation of the novel The Question of Red (TQOR) and Amba experienced distinction in the lexical category of style markers which led to a potential difference in the self-translator's ideology. A qualitative research method with Fairclough's critical discourse analysis approach was used to reveal the ideological representation. The data sources are an English novel, TQOR, and its Indonesian translation, Amba. The research data are nouns in source text and their translation which represent the self-translator’s ideology. The analysis followed Fairclough’s model of description, interpretation, and explanation. The results show that the ST has more nouns as the lexical style markers than the TT. In both texts, abstract nouns are used more frequently than concrete nouns which offers more affective involvement so that the readers of both texts can feel the experience of the characters rather than giving sensory perceptions to the readers. Keywords: ideological representation, style markers, nouns, self-translation AbstrakPenerjemahan karya sastra selalu dihadapkan pada permasalahan kesepadanan, kesetiaan, keakuratan, dan kealamiahan yang dapat menjadi lebih rumit karena pengarang dapat menggunakan gaya bahasa yang khusus. Penelitian ini membahas kasus penerjemahan karya sastra yang dilakukan oleh pengarangnya sendiri (swaterjemah). Penelitian ini bertujuan melihat apakah kasus swaterjemah novel The Question of Red (TQOR) dan Amba mengalami pergeseran gaya bahasa kategori leksikal yang mengarah pada potensi pergeseran ideologi pengarang-penerjemah. Metode penelitian kualitatif dengan analisis wacana kritis Fairclough digunakan untuk mengungkap ideologi pengarang-penerjemah. Sumber data berupa novel berbahasa Inggris, TQOR, dan terjemahan bahasa Indonesianya, Amba. Data penelitian adalah nomina di dalam TSu dan terjemahannya dalam TSa yang merepresentasikan persepsi ideologis pengarang-penerjemah. Analisis menggunakan model AWK Fairclough, yaitu deskripsi, interpretasi, dan eksplanasi. Hasil penelitian menunjukkan bahwa TSu memiliki lebih banyak pemarkah gaya bahasa kategori leksikal nomina daripada TSa. Pada kedua teks, nomina abstrak lebih banyak digunakan daripada nomina konkret. Dengan demikian pengarang-penerjemah lebih menawarkan keterlibatan afektif agar pembaca turut merasakan pengalaman tokoh-tokohnya daripada memberikan persepsi indrawi. Kata Kunci: representasi ideologis, gaya bahasa, nomina, swaterjemah