bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical Analysis for the hemodynamics mechanism of a curved artery having multiple stenosis
Authors: Nadeem Sohail , Akhtar Salman , Saleem Anber , Almutairi Shahah , Ghazwani Hassan Ali , Eldin Sayed M 
Published: September 2022

Abstract
The surgical intercede firstly requires the spotting and quantification of stenosis. The analysis of blood flow in such arteries lead to the prediction of hemodynamics mechanism in these diseased arteries. It is further helpful in designing the devices that imitates the blood flow and in diagnostic tools formation. The hemodynamics mechanism of a curved artery having multiple stenosis is interpreted. An exact as well as a numerical solution approach is utilized in the present analysis. Since blood flow is usually turbulent in such stenosed arteries and the advantage of using numerical approach is that we have also considered the turbulent flow phenomena in this curved artery. Exact solutions provide the line graphs for this flow problem while the numerical simulations are obtained by using the free source OPENFOAM software. The numerical approach is more convenient to consider the desirable location of stenosis. It means that we can construct various complex geometries with multiple locations of stenosis more conveniently by using the numerical approach.
The impact of tungsten oxide (WO3) nanoparticles, embedded in Guar gum based hydrogel for water treatment applications
Authors: Ahmad Alishbah Iftikhar , Hassan Safia , Ahmed Toqeer , Imran Zahid , Batool Syeda Sitwat , Abbass Aun 
Published: September 2022

Abstract
In this research work, a novel guar gum based membrane was fabricated that was further reinforced with tungsten oxide (WO3) nanoparticles (NPs) respectively for the removal of methyl violet (MV) dye from aqueous solution. The membranes were characterized by Fourier Transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) which confirms the presence of functional groups, rough and smooth surface morphology with porous structure and X-ray diffraction (XRD) shows specific peaks approves the NPs of WO3 respectively. The swelling study of membranes was performed by using various parameters i.e. maximum swelling were attained at neutral pH 7, water transport mechanism was followed the Fickain diffusion and the gel content was linearly increased 91–95%. The adsorption efficiency of membrane for virulent dye (MV) was investigated by following parameters i.e. the adsorption of dye was maximum at pH 10 and 96% of dye was removed at 60 mins. The kinetic data for adsorption process was best fitted with pseudo first order kinetic model which shows the physisorption of dye and isothermal data for Langmuir-Freundlich model shows multilayer adsorption. The negative ∆H values indicates the exothermic reaction. Furthermore, pre and post analysis of water samples (drinking tap water and contaminated water) were used to examine the physiochemical parameters such as colour, odour, pH, conductivity, TDS and DO (dissolve oxygen) by using the synthesized membrane. The fast uptake capacity of dye removal and the physicochemical parameters of contaminated water was observed by friendly nature of membrane.
How the age of the head of households matter in the incidence of financial inclusion on energy poverty in Ghana
Authors: Asongu Simplice , Njangang Henri , Nchofoung Tii , Diop Samba 
Published: September 2022

Abstract
We extend Koomson and Danquah (2021, EP) in order to understand if and how the age of the household head matters in the incidence of financial inclusion on energy poverty in Ghana. We revisit the underlying study within a framework of interactive regressions in order to establish household head ages that should be avoided in order for financial inclusion to continuously reduce energy poverty. In the estimation exercise that is based on pooled data and two stage least squares, we establish a negative net effect from the role of household head age in moderating the incidence of financial inclusion on energy poverty. An extended analysis provides household head ages that should be avoided in order for financial inclusion to reduce energy poverty. These critical household head ages are contingent on the area of household (i.e. rural versus urban) as well as the gender of household age( male versus female).
JEL Classification: D03; D12; D14; I32; Q41
Artificial microRNA suppresses C9ORF72 variants and decreases toxic dipeptides in vivo
Authors: Cabrera Gabriela Toro , Meijboom Katharina , Abdallah Abbas , Tran Helen , Foster Zachariah , Weiss Alexandra , Wightman Nicholas , Stock Rachel , Gendron Tania , Gruntman Alisha , Giampetruzzi Anthony , Petrucelli Leonard , Brown Robert , Mueller Christian 
Published: September 2022

Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor neurons, causing progressive muscle weakness and respiratory failure. The presence of an expanded hexanucleotide repeat in chromosome 9 open reading frame 72 (C9ORF72) accounts for most cases of familial ALS and frontotemporal dementia (FTD). To determine if suppressing expression of C9ORF72 gene products can reduce toxicity, we designed a set of artificial microRNAs (amiRNA) targeting the human C9ORF72 gene. Here we report that an AAV9-mediated amiRNA significantly suppresses expression of the C9ORF72 mRNA, protein, and toxic poly-dipeptides generated by the expanded repeat in the brain and spinal cord.
Fe3O4/SiO2 decorated trimesic acid-melamine nanocomposite: A reusable supramolecular organocatalyst for efficient multicomponent synthesis of imidazole derivatives
Authors: Fattahi Babak , Dekamin Mohammad G 
Published: September 2022

Abstract
This article describes supramolecular Fe3O4/SiO2 decorated trimesic acid-melamine nanocomposite that can be prepared with features that combine properties of different materials to fabricate a structurally unique hybrid material. In particular, we have focused on design, synthesis and evaluation a heterogeneous magnetic organocatalyst with acidic functional-groups for synthesis of biologically important imidazole derivatives in good-to-excellent yields. The introduced Fe3O4/SiO2-TMA-Me were characterized by different techniques such as FTIR, XRD, EDX, FESEM, TEM and TGA. As a noteworthy point, the magnetic catalyst system can be recycled and reused for more than seven consecutive cycles while its high catalytic activity remains.
Competitive study of heat-exposed and non-heat-exposed group of workers of Underground Coal Mines, Punjab, Pakistan
Authors: Ijaz Madiha , Ahmad Sajid rashid , Akram Muhammad , Mirza kamran , Carter William 
Published: September 2022

Abstract
Aim
To identify prevalence and comparison of heat-induced illnesses among. Design: cross-sectional survey and comparison. Methods: Ingestible thermometric pills, skin temperature probes, US-NIOSH heat stress sheet and general questionnaire were used to study 50 coal cutters (25 from 5 hot mines (G1) and 25 from 5 non-hot mines (G2)). Results: The highest monitored temperature was 33.6 0C in mine 1 and humidity 83.3% in mine 3. Comparing values of two groups of mines, the p-value was < 0.001 for Wet Bulb Globe Temperature and Dry Bulb Temperature, and 0.031 for Relative Humidity. The highest core body temperature (38.80C) and skin temperature (36.60C) were in workers of G1, who also reported symptoms of heat-illness for 3 + days/week. Post-shift samples (of blood and urine) from G1 showed that the hematocrit (%) reduced to 43.6 ± 2.1 from 45.4 ± 1.4, eGFR reduced from100 ± 19 to 94 ± 09 mL/min/1.72m2. Public contribution: Performing exertive work in hot environment prompts heat-induced-illnesses.
Stratification and temporal evolution of mixing regimes in diurnally heated river flows
Authors: Nguyen-Dang Cindy , Williamson Nicholas , Armfield Steven W. , Kirkpatrick Michael , Norris Stuart E. 
Published: September 2022

Abstract
Direct numerical simulations of stratified open channel flows subject to a varying surface heat flux is performed. The influence of the diurnal heating time on the spatial and temporal variation of mixing in the flow and the characteristics of the mean flow state is also examined. The bulk buoyancy parameter 𝝀𝑩 is defined through the ratio of the channel height 𝜹 and a bulk Obukhov length scale 𝓛𝑩. The non-dimensional diurnal time scale ˆ𝒕 is defined as the ratio of the heating time to an eddy turnover time. The Prandtl number 𝑷𝒓 and Reynolds number 𝑹𝒆𝝉 is limited to 1 and 400, respectively, with ˆ𝒕 ranging between 1 to 24. A regime map for each behaviour of the laminar layer depth (LLD) and stratified layer depth (SLD) is presented. The LLD is defined as the depth when the buoyancy Reynolds number 𝑹𝒆𝑩 ≤ 7 and the SLD is the depth when the turbulent Froude number 𝑭𝒓 ≤ 1. Three classifications exist for each layer depth. The first; a neutral flow where the LLD or SLD does not exist, denoted by NL and NS, respectively. The second is a stratified flow where the LLD or SLD are diurnally varying, denoted as DL and DS. The last describes a persistent layer of the LLD or SLD, denoted as PL and PS. The transition between the NL to DL is ˆ𝒕 ∝ 𝑹𝒆𝓛4.5, DL to PL is ˆ𝒕 ∝ 𝑹𝒆𝓛−0.5, NS to DS is ˆ𝒕 ∝ 𝝀0 and DS to PS is ˆ𝒕 ∝ 𝝀1. These classifications form the basis of the regime map for this flow.
Effects of the anti-inflammatory drug celecoxib on cell death signaling in human colon cancer
Authors: Maruyama Ryuto , Kiyohara Yuki , Sugiyama Tomoyasu 
Published: September 2022

Abstract
The anti-inflammatory drug celecoxib, the only inhibitor of cyclooxygenase-2 (COX-2) with anticancer activity, is used to treat rheumatoid arthritis and can cause endoplasmic reticulum (ER) stress by inhibiting sarco/ER Ca2 + -ATPase activity in cancer cells. This study aimed to investigate the correlation between celecoxib-induced ER stress and the effects of celecoxib against cell death signaling. Treatment of human colon cancer HCT116 cells with celecoxib reduced their viability and resulted in a loss of mitochondrial membrane potential (ΔΨm). Additionally, celecoxib treatment reduced the expression of genes involved in mitochondrial biogenesis and metabolism such as mitochondrial transcription factor A (TFAM) and uncoupling protein 2 (UCP2). Furthermore, celecoxib reduced transmembrane protein 117 (TMEM117) and RNAi-mediated knockdown of TMEM117 reduced TFAM and UCP2 expression. These results suggest that celecoxib treatment results in loss of ΔΨm by reducing TMEM117 expression and provide insights for the development of novel drugs through TMEM117 expression.
The expression of ion channels in sensory neurons that can shift action potential in direction to hyperpolarization are dysregulated in patients with chronic kidney disease–associated pruritus
Authors: Momose Akishi , Yabe Michihiro , Chiba Shigetoshi , Kumakawa Kenjirou , Shiraiwa Yasuo , Mizukami Hiroki 
Published: September 2022

Abstract
Background: Expression levels of voltage-dependent T-type calcium channel subunit alfa 1H (Cav3.2), big conductance calcium-activated potassium channel (BKCa), and anoctamin 1 in the skin, including in peripheral nerve endings were previously found to be significantly elevated in patients with chronic kidney disease (CKD)–associated pruritus (CKD-aP). On the other hand, the expression of transient receptor potential 1 was significantly reduced.
Methods: We further compared CKD patients with and without CKD-aP in terms of the expression levels of several ion channels Based on CKD-aP severity, subjects were divided into two groups: non-CKD-aP (no or slight pruritus; n = 16) and CKD-aP (mild, moderate, or severe pruritus; n = 16). Skin samples were obtained from the forearm or elbow during arteriovenous fistula surgery. We used quantitative reverse transcriptional polymerase chain reaction (RT-PCR)to measure the skin expression levels of the following ion channels in the skin: voltage gated sodium channel 1.7 (Nav1.7), voltage gated potassium channel 7.2 (Kv7.2), TWIK-related K+ channel 1 (TREK1), hyperpolarization-activated cyclic nucleotide-gated channel type 2 (HCN2), tyrosine kinase receptor A (TrkA), and piezo-type mechano-sensitive ion channel component 2 (Piezo2).
Results: RT-PCR analyses showed that CKD-aP patients had significantly higher levels of TREK1 and Piezo2 transcripts and significantly lower levels of HCN2 transcripts than non–CKD-aP patients. No significant differences were noted between groups in the expression of Nav1.7 or TrkA. Moreover, Kv7.2 transcripts were not detected in either group.
Conclusion: In skin samples collected from CKD-aP patients, ion channel expression patterns were altered to enhance hyperpolarization of pruriceptive neurons.
A study of public concern and awareness of national parks in China from the perspective of “big data + small data” fusion
Authors: Dou Yaquan , Wu Changhao , He Youjuna 
Published: September 2022

AbstractThe high-quality development of national parks is an important way to protect biodiversity. Understanding public concern for and awareness of national parks is necessary to promote greater public participation in the management of national parks. A lack of participation by the Chinese public has limited the development of high-quality national parks in China. The present study provides insight into this problem by combining Weibo and questionnaire survey data and uses a combination of text mining, an Latent Dirichlet Allocation(LDA) theme model, and descriptive statistics to analyze the current state of public concern for and awareness of national parks. The results show that with the in-depth practice of ecological civilization construction, public concern of national parks is increasing year by year. Most Chinese residents are willing to actively pay attention to the construction of national parks, especially those in the more economically developed regions. Currently, public concern for national parks focuses on the construction of national parks in other countries and the institutional reform and ecotourism of national parks in China. However, the public is not yet fully aware of national parks in China. The number of national parks, their construction, and other issues are still not widely known. Similarly, awareness of the construction goals, functional positioning, and other issues are not generally understood. This study will help policy makers to understand the public concern and awareness of national parks and provide a reference for the establishment of targeted public participation mechanisms, which will be important for development of natural reserve system in China and global biodiversity protection.
Gunshot bullet trauma of the colon in combat patients injured in hybrid period of Russian-Ukrainian war during 2014-2020
Authors: Gumeniuk Kostiantyn , Lurin Igor A. , Tsema Ievgen , Malinovska Lesia , Gorobeiko Maksym , Dinets Andrii 
Published: September 2022

Abstract
Background
Gunshot wound to the colon is a frequent injury in armed conflicts. An example of high-energy modern weapon is hollow-point bullets, which is associated with an increased tissue damage and lethal outcome. The aim of this study was to evaluate gunshot injuries to the colon in combat patients and to investigate specific features of the hollow-point and shape-stable bullets features in colon injury.
Patients and methods
Analyses of clinical data was performed on 384 male soldiers from Armed Forces of Ukraine with gunshot abdominal wound with injury to the colon in East Ukraine between 2014 and 2020. Out of 374 injured, 112 (29.9%)patients were diagnosed with penetrating gunshot bullet wounds: 69/112 (61.6%) were injured by shape-stable bullets and 43/112 (38.4%) patients were injured by the hollow-point bullets.
Results
More severe hemorrhagic shock stages were in patients injured by hollow-point bullets: shock stages III-IV was in 25 (58.1%) patients injured by the hollow-point bullets vs. 17 (24.6%) patients injured by shape-stable bullets (p=0.0004). Left colon parts were more frequently injured as compared to right colon side or transverse colon in 21 (48.8%) injured by shape-stable (p<0.0001) and in 41 (59.4%) patients injured by the hollow-point bullets (p=0.032). A significant difference was identified for the frequent injury to the middle colon within the entire cohort (p = 0.023). Patients injured with the hollow-point bullets demonstrated a higher frequency of 3-5 areas of colon penetration, which was detected in 18 (41.8%) patients injured by hollow-point bullets and none patients with shape-stable bullets injury (p=0.0001). Colon Injury Scale (CIS) IV was detected in 9 (8%) patients injured by the hollow-point bullets as compared to 7 (10.1%) patients injured by shape-stable bullets (p=0.031). Colostomy was performed in 9 (13%) patients injured by shape-stable bullets and in 8 (19%) patients injured by the hollow-point bullets (p>0.05). 15 (35%) patients died after injury by the hollow-point bullet, whereas 9 (13%) patients after injury by the shape-stable bullets (p=0.0089).
Conclusions
All patients should be suspected to have a hollow-point injury in case of penetrating injury (absent outlet wound) and careful revision of the abdomen must be performed to identify possible multiorgan injury as well as multiple perforations of the intestine.
Value Of Dual Source Cardiac CT In Children And Young Adults With Congenital Heart Disease And Infective Endocarditis Role of CT in the management of pediatric infective endocarditis
Authors: Nagiub Mohamed , Fares Munes , Ganigara Madhusudan , Ullah Sana , Hsieh Nathan , Jaquiss Robert , Dillenbeck Jeanne , Hussain Tarique 
Published: September 2022

Abstract
Background:
Diagnosis of Infective Endocarditis (IE) can be challenging due to negative blood cultures and difficulties in imaging. Transesophageal echocardiography (TEE) is the gold standard but due to the anterior location of the pulmonary valve and sedation requirement, TEE could be challenging. The aim of this study was to assess the value of Cardiac CT (CCT) for IE in children and young adults with congenital heart disease (CHD).
Methods:
This is a retrospective review of pediatric patients with CHD and diagnosis of IE who underwent CCT (2018-22). Retrospectively Gated CCT was performed. Data collected included age, gender, cardiac diagnosis, clinical presentation, echocardiographic / CCT/ PET findings, and blood culture results. In addition, Modified Duke criteria(MDC) for the diagnosis of IE were applied with and without CCT as the diagnostic imaging criterion.
Results:
Fourteen patients were included in this study with median age 11 years old. Nine patients were female. Ten of 14 patients had IE of the RV-PA conduit and 4 patients had IE of the aortic valve. Using MDC, 4 patients had definite IE. Including CCT findings 11 patients (79 %) met MDC for definite IE. Blood cultures were positive in 12 patients. CCT revealed the following complications: thromboembolic findings / pseudoaneurysms in 5 patients each and prosthetic valve perforation/ prosthetic valve leak in one patient each.
Conclusions:
This study reinforces the complimentary role of CCT to echocardiography in the work up and diagnosis of IE in patients with CHD. With further improvement in lower radiation exposure, CCT may have a key role in the diagnostic work up of endocarditis and could be implemented in the diagnostic criteria of IE.
Remarkable Effect of Increasing Glutamine Metabolism on Caveolin-1 in Breast Cancer: A Brief Report
Authors: Mostafavi Samaneh , Hadjati Jamshid , Mostafazadeh Amrollah , Hassan Zuhair Mohammad 
Published: September 2022

Abstract
Background
Caveolin-1(CAV-1) is a key molecule in cancer metabolism and progression and decrease in highly metastatic breast cancer cells. Moreover, glutamine is a crucial amino acid in the tumor microenvironment, and cancer cells are addicted to it. The effect of glutamine metabolism on caveoline-1 was not completely clarified. However, metformin has been demonstrated in separate studies to impair glutamine metabolism, and also affect caveoline-1 expression. Hence, the focus of this study is to evaluate the effect of glutamine metabolism on caveoline-1 expression, and to examine if metformin could affect caveoline-1 in high glutamine media.
Methods
In this study, 4T1 breast cancer cell line was cultured in different concentrations of glutamine. Caveolin-1 expression was assessed, using immunocytochemistry test. We also conducted MTT assay to evaluate optimum dose for metformin. To understand if metformin could regulate caveoline-1 expression in high glutamine media, 5mM of metformin was administrated and compared with control.
Results
our results indicated that glutamine metabolism significantly decreased CAV-1. On the other hand, administration of 5mM metformin for 24 hours efficiently re-expressed CAV-1.
Conclusion
High level of glutamine significantly decreased CAV-1, which may up-regulate the possibility of breast tumor speared, metastasis and metabolic reprogramming. Metformin, however, could be a promising drug, targeting glutamine metabolism to re-express caveoline-1, inhibiting tumor progression and metastasis.
A Coupled Mathematical Model between bone remodeling and tumors: A study of different scenarios usingKomarova’s model
Authors: Ramtani Salah , Garzon-Alvarado Diego , Sánchez Juan Felipe , Vaca-González Juan Jairo 
Published: September 2022

Abstract
1 Abstract This work aims to construct a general framework of coupling tumor-bone remodeling processes for having plausible outcomes of the effects of tumors on the number of osteoclasts, osteoblasts, and the frequency of the bone turnover cycle. Here, Komarova’s model has been extended to include the effect of tumors on the bone remodeling processes. Thus, we explored three alternatives for coupling tumor presence into Komarova’s model: first, using a ”damage” parameter that depends on the tumor cell concentration. A second model follows the original structure of Komarova, including the tumor presence in those equations powered up to a new parameter, called the paracrine effect of the tumor on osteo-clasts and osteoblasts; the last model is replicated from Ayati and collaborators in which the impact of the tumor is included into the paracrine parameters. Through the models, we studied their stability and considered some examples that can reproduce the tumor effects seen in clinic and experimentally. Therefore, this paper has three parts: the exposition of the three models, the results and discussion (where we explore some aspects and examples of the solution of the models), and the conclusion. The authors hope this paper can be the first step for being used as a research framework for those who want to run mathematical models of coupling tumor-remodeling process as a silicon laboratory of possible effects.