bluuebunny/crossref_metadata_2025_split huggingface dataset:
Full left/full right liver graft ex situ split during hypothermic oxygenated perfusion
Authors: Rossignol Guillaume , Muller Xavier , Mohkam Kayvan , Dubois Remi , Lesurtel Mickaël , Mabrut Jean‐Yves 
Published: April 2022

AbstractBackgroundEx vivo split liver transplantation in pediatric recipients has shown inferior results compared with whole grafts. One factor among others contributing to split grafts being considered as marginal is the prolonged static cold storage time related to ex vivo liver splitting. End ischemic hypothermic oxygenated perfusion is a validated strategy to improve outcomes of marginal whole grafts and may thus also benefit split liver grafts.MethodWe present the first case of full left/full right split procedure performed during hypothermic oxygenated perfusion.ResultsWe present a standardized surgical two‐step approach where parenchymal transection was performed during end ischemic hypothermic oxygenated perfusion via the portal vein to shorten static cold storage duration. Both split grafts were successfully transplanted in a 4‐year‐old pediatric and a 38‐year‐old adult recipient. Despite high‐risk procedure (retransplantation), extended donor criteria including a prolonged cardiac arrest and high donor risk index (2,25), both grafts showed early recovery of hepatic function and low serum transaminase release. At 6 months, both recipients were alive with a normal liver biology and a functioning graft.ConclusionAlthough challenging, full left/full right liver split procedure during end ischemic hypothermic oxygenated perfusion can be successfully performed and is a promising strategy to improve post‐transplant outcomes.
Religious social capital and minority health: A concept analysis
Authors: Conley Cherie , Gonzalez‐Guarda Rosa , Randolph Schenita , Hardison‐Moody Annie , Fisher Edwin B. , Lipkus Isaac 
Published: April 2022

AbstractObjectiveOptimizing resources within environments where people live, work, and pray can aid nurses in improving public health. Religion and social capital significantly influence the health of individuals and communities, particularly among racial and ethnic minorities in the United States. A concept analysis of religious social capital was conducted to clarify how this resource is used in the context of health.Design and SampleRodgers’ evolutionary concept analysis method guided this analysis. A search of PubMed, CINAHL, and PsycINFO, using keywords “religious social capital” and “health” yielded 152 publications.ResultsAntecedents were “defined religious social network,” “voluntary membership,” “shared values,” and “trust.” Attributes were “relationships (bonding bridging, and linking),” “information exchange and resource sharing,” and “reciprocal participation.” Consequences were “increased productivity,” “increased resources,” “better personal and community health,” and “trust.” A model case of African American women and HIV prevention was included to illustrate how religious social capital can be developed and optimized to promote health.ConclusionReligious social capital is defined as increased individual and collective capabilities that result from voluntary and reciprocal participation in bonding, bridging, or linking social network relationships and activities. Religious social capital is an accessible resource that can be leveraged to improve minority health.
Leishmania LiHyC protein is immunogenic and induces protection against visceral leishmaniasis
Authors: Machado Amanda S. , Lage Daniela P. , Vale Danniele L. , Freitas Camila S. , Linhares Flávia P. , Cardoso Jamille M. O. , Oliveira‐da‐Silva João A. , Pereira Isabela A. G. , Ramos Fernanda F. , Tavares Grasiele S. V. , Ludolf Fernanda , Bandeira Raquel S. , Maia Luiz G. N. , Menezes‐Souza Daniel , Duarte Mariana C. , Chávez‐Fumagalli Miguel A. , Roatt Bruno M. , Christodoulides Myron , Martins Vívian T. , Coelho Eduardo Antonio Ferraz 
Published: April 2022

AbstractTreatment against visceral leishmaniasis (VL) presents problems by the toxicity of drugs, high cost and/or emergence of resistant strains. The diagnosis is hampered by variable sensitivity and/or specificity of tests. In this context, prophylactic vaccination could represent a control measure against disease. In this study, the protective efficacy of Leishmania LiHyC protein was evaluated in a murine model against Leishmania infantum infection. LiHyC was used as recombinant protein (rLiHyC) associated with saponin (rLiHyC/S) or Poloxamer 407‐based polymeric micelles (rLiHyC/M) to immunize mice. Animals received also saline, saponin or empty micelles as controls. The immunogenicity was evaluated before and after the challenge, and results showed that vaccination with rLiHyC/S or rLiHyC/M induced the production of high levels of interferon‐gamma (IFN‐γ), interleukin (IL)‐12 and granulocyte‐macrophage colony‐stimulating factor in cell culture supernatants, as well as higher IFN‐γ expression evaluated by RT‐qPCR and involvement from CD4+ and CD8+ T‐cell subtypes producing IFN‐γ, tumor necrosis factor‐α and IL‐2. A positive lymphoproliferative response was also found in cell cultures from vaccinated animals, besides high levels of rLiHyC‐ and parasite‐specific nitrite and IgG2a antibodies. Immunological assays correlated with significant reductions in the parasite load in the spleens, livers, bone marrows and draining lymph nodes from vaccinated mice, when compared to values found in the controls. The micellar composition showed slightly better immunological and parasitological data, as compared to rLiHyC/S. Results suggest that rLiHyC associated with adjuvants could be considered for future studies as a vaccine candidate against VL.
Severe maternal morbidity and other perinatal complications among women with physical, sensory, or intellectual and developmental disabilities
Authors: Horner‐Johnson Willi , Garg Bharti , Darney Blair G. , Biel Frances M. , Caughey Aaron B. 
Published: April 2022

AbstractBackgroundLittle is known about severe maternal morbidity (SMM) among women with disabilities.ObjectiveWe assessed differences in SMM and other perinatal complications by presence and type of disability. We hypothesised that SMM and other complications would be more common in births to women with disabilities than to women without disabilities.MethodsWe conducted a retrospective cohort study of California births from 2000 to 2012, using birth and death certificate data linked with hospital discharge data. We included singleton deliveries with gestational age of 23–42 weeks. We classified women as having any disability or not and identified disability type (physical, hearing, vision, intellectual/developmental disabilities [IDD]). Our primary outcome was a composite indicator of SMM. Secondary outcomes included additional perinatal complications: gestational hypertension, preeclampsia, gestational diabetes, venous thromboembolism, chorioamnionitis, puerperal endometritis and mental health disorders complicating pregnancy, childbirth or the puerperium. We used modified Poisson regression to obtain covariate‐adjusted relative risks (RR) and 95% confidence intervals (CI) for the association of disability status and type with SMM and secondary outcomes.ResultsOf 5,787,090 deliveries, 33,044 (0.6%) were to women with disabilities. Of these, 311 per 10,000 were complicated by SMM, compared with 84 per 10,000 deliveries to women without disabilities. In multivariable analyses, risk of SMM for births to women with disabilities was nearly three times that for women without disabilities (RR 2.84, 95% CI 2.67, 3.02). Proportion and risk of SMM were greatest for vision disability (793 per 10,000; RR 4.04, 95% CI 3.41, 4.78). Secondary outcomes were also more common among women with disabilities. In particular, more than a third of births to women with IDD (37.4%) were complicated by mental health disorders (versus 2.2% for women without disabilities).ConclusionAs hypothesised, SMM and other perinatal complications were more common among women with disabilities than among women without disabilities.
Mineral supplementation (injectable) improved reproductive performance in Holstein cows managed in a warm summer environment
Authors: Del Río‐Avilés Andrea D. , Correa‐Calderón Abelardo , Avendaño‐Reyes Leonel , Macías‐Cruz Ulises , Thomas Milton G. , Enns R. Mark , Speidel Scott E. , Sánchez‐Castro Miguel A. , Zamorano‐Algandar Ricardo , López‐Castro Pedro A. , Luna‐Nevárez Pablo 
Published: April 2022

AbstractSustainability of dairy production depends largely on reproductive efficiency that is affected by heat stress due to high ambient temperature and humidity during summer. Supplementation of minerals has been proposed as a management strategy to minimize adverse impact of heat stress on fertility. The objective of this study was to determine the effects of an injectable mineral supplement (Fosfosan) containing selenium (Se), copper (Cu), potassium (K), magnesium (Mg) and phosphorus (P) on the ovarian structures, reproductive hormones and conception rate of heat‐stressed Holstein cows. Sixteen cows were assigned during summer to one of two treatments, a control group (CON; n = 8) and a mineral‐supplemented group (SUP; n = 8). Ambient temperature and relative humidity records were collected and processed to estimate the temperature–humidity index (THI), which confirmed a heat‐stressed environment during the study (avg. THI = 79.4). Cows were subjected to a fixed‐time artificial insemination (FTAI) program using the CIDR‐Synch synchronization protocol. Traits indicative of ovarian activity were recorded during and after this protocol, as well as serum concentrations of reproductive hormones. Pregnancy diagnosis was made 28 and 35 d after FTAI. A completely randomized block design with repeated measures over time was performed to study ovarian functional structures and its hormonal profiles. Correlations and regressions were estimated to study relationships between ovarian structures and related hormones. Mineral supplementation did not increase follicular diameter or follicular populations (p > .05), yet tended to increase corpus luteum diameter (p < .10), and it enhanced (p < .01) oestrogen and progesterone serum concentrations and improved (p < .05) cow's conception rate. Diameter of dominant follicles and corpus luteum was correlated (p < .05) with oestrogen and progesterone levels, respectively, but only in mineral‐treated cows. Two additional dairy herds were evaluated to confirm that mineral supplementation improved conception rate during the heat stress period (objective 2). Cows from dairy 1 received FTAI during winter (n = 401) and summer (n = 240), whereas cows from dairy 2 were bred after natural detected oestrus during winter (n = 558) and summer (n = 314). Conception rates were higher (p < .05) in winter than summer and they improved (p < .05) with mineral supplementation, but only in cows managed during summer. In conclusion, supplementation of minerals enhanced hormonal secretion from ovarian structures and improved conception rate in Holstein cows exposed to summer heat stress.
Applying the precautionary principle to Fukushima nuclear wastewater disposal at sea
Authors: Li Ruoying , Lyu Shuang 
Published: April 2022

AbstractNuclear power undoubtedly offers a cleaner alternative source of energy, but its use is recurrently threatened by nuclear catastrophes and inappropriate waste management. The nuclear accident at the Fukushima Daiichi nuclear power plant and the decision by the Japanese government to dispose its nuclear wastewater at sea best illustrate these problems. Instead of considering the best outcome for the environment, the decision is rather based on economic factors, such as on‐site tanks reaching full capacity. Endorsing the application of the precautionary principle for this case will protect health and the environment from irreversible damage, redistribute the disproportionate burden borne by the exposed population to the risk‐generators and ensure that the decision making can be justified based on shared wealth instead of shared risks.
Peritoneal calprotectin level in peritoneal dialysis patients
Authors: Sevik Gizem , Barutcu Atas Dilek , Ilgin Can , Asicioglu Ebru , Tuglular Serhan , Velioglu Arzu 
Published: April 2022

AbstractBackgroundCalprotectin is an important molecule in the initiation and progression of the inflammatory process. Systemic and local intraperitoneal inflammation are distinct processes and consequences in peritoneal dialysis (PD). We aimed to evaluate dialysate calprotectin levels and its associations with peritonitis and dialysis adequacy in PD patients.MethodsForty‐four PD patients were included in this prospective study. Calprotectin concentration was evaluated in 24‐h peritoneal drainage fluid. Patients were followed‐up for 1 year, and peritonitis episodes were recorded. Dialysate calprotectin levels were compared to dialysis adequacy parameters and peritonitis frequency.ResultsThe mean age of patients was 54.9±12.7 years. Median PD duration was 54 (23–76) months. Seventeen patients (38.6%) had previous peritonitis episodes. During follow‐up, 15 of 44 patients (34.1%) had peritonitis. The median calprotectin concentration was 79.5 (75.2–86.3) ng/ml. The patients were divided into low and high calprotectin groups according to median value. In the high calprotectin group, BMI was found higher (p = 0.04). There was no significant relationship between calprotectin concentration and peritonitis during follow‐up (p = 0.29). However, the patients that have had previous peritonitis had higher calprotectin concentrations (p = 0.02). The patients who had higher erythrocyte sedimentation rate (ESR) levels also had higher calprotectin concentrations (p = 0.01).ConclusionPeritoneal calprotectin concentrations were correlated with higher BMI and ESR, and it was higher in patients with previous peritonitis episodes. To our knowledge, this is the first study to examine the peritoneal calprotectin levels in PD patients. Further studies are needed to determine the use of peritoneal calprotectin as an inflammatory marker in PD.
Improving the Rheological and Mechanical Properties of Oil Well Cement Slurries Using Multiple Chemical Admixtures for Enhancing Zonal Isolation: A Laboratory Evaluation
Authors: Elahifar Behzad , Hosseini Erfan 
Published: April 2022

Abstract
The study uses chemical and mineral admixtures to understand the critical processes affecting the cement slurry characteristics, including rheological properties, free water, compressive strength, and thickening time. Using alternate mineral admixtures to replace cement slurry partially has environmental and economic benefits. The mechanisms behind the effects of chemical admixtures on the parameters of cement slurry were investigated at different temperatures using cutting-edge experimental equipment. The binder's compatibility and reactions with chemical admixtures were examined. When temperature and chemical admixtures are combined, it has a major effect on the flow characteristics of slurries. The results suggested that present technical data for chemical admixtures must be confirmed for use in oil well cementing; admixtures that are efficient at raised temperatures in conventional cementing work may become ineffective at elevated temperatures in oil well cementing. Finally, the new mixture can be employed in the desired oil field due to this new material generation (4200–6900 feet and pressure and temperature range of 4100–4800psi and 140–170 °F, respectively). Because this mixture enhances the rheological properties of cement slurry, the end product will be better than the current version. After all, the plastic viscosity, apparent viscosity, and yield stress diagrams of mixture #3*-A are lower than the desired oil field. The other mixtures in this study lead to a decrease in cement slurry viscosity and have the highest compressive strength. Finally, mixture #3*-A was the optimal blend.
Leakage Characteristics of a Novel Hole-Pattern Damping Seal With Dovetail-Like Diversion Grooves: Numerical Simulation and Experiment
Authors: Jiang Jinbo , Zhang Xuan , Zhao Wenjing , Ma Yi , Peng Xudong 
Published: April 2022

Abstract
Reasonable design of the cavity shape of the damping hole effectively reduces the leakage rate of the hole-pattern damping seal (HPDS). A novel HPDS with dovetail-like diversion grooves was proposed, and the geometry outline of the dovetail-like diversion groove was described by using the hyperelliptic curve. Computational fluid dynamics commercial software was used to simulate the three-dimensional flow field of the dovetail-like hole-pattern damping seal (D-HPDS). The leakage characteristics of the damping seals with a typical circular hole, leaf-like hole, and dovetail-like hole were compared numerically and experimentally. The three-velocity zone model of HPDS was proposed to reveal the mechanism of leakage reduction effect of the D-HPDS compared with typical circular hole-pattern damping seal (C-HPDS). The influence of operating parameters and key geometric parameters on leakage characteristics of the D-HPDS was studied. The results show that the leakage rate of the D-HPDS can be reduced significantly in a wide range of operating conditions and seal clearance compared with the typical C-HPDS, and the maximum reduction amplitude of leakage rate reaches up to 25% at a relatively small pressure ratio. The main reasons for the leakage reduction of the D-HPDS can be explained by the fact that the change of outflow direction from the cavity induced by the interaction effect of adjacent cavities, further resulting in the formation of turbulent vortex in the cavity and the low-speed flow zone in the sealing gap. For the design goal of low leakage rate, the inclined angle of the dovetail-like diversion groove is appropriate between 45 deg and 55 deg, the tip extension ratio is appropriate between 0.8 and 0.95.
Paleoproterozoic–Paleozoic tectonic evolution of the Longshou Shan, western North China craton
Authors: Wu Chen , Li Jie , Zuza Andrew V. , Haproff Peter J. , Yin An , Ding Lin 
Published: April 2022

Abstract
The Longshou Shan of western China is the northern backstop of the Cenozoic Himalayan-Tibetan orogen and occupies a key linkage between the Tarim continent and North China craton which separate the pre-Cenozoic Tethyan orogenic system and Central Asian orogenic system. Therefore, the Paleoproterozoic–Paleozoic evolution of this region is critical to understanding the extent of overprinting Cenozoic deformation, construction of the Eurasian continent, and relationships between the pre-Cenozoic Tethyan orogenic system and Central Asian orogenic system. Here we present detailed field observations and results of geochronological and major and trace element and Sr-Nd isotope geochemical analyses of samples from the Longshou Shan to decipher its complex Paleoproterozoic–Paleozoic tectonic history. Our results show that the Paleoproterozoic basement rocks of the Longshou Shan were part of the North China craton and involved in Paleoproterozoic northern North China orogeny. A ca. 965 Ma granitoid in the Longshou Shan provides key evidence for a spatial linkage between northern Tibetan continents, the North Tarim continent, and the North China craton in the early Neoproterozoic. The presence of Early Ordovician granitoids and arc volcanic rocks in the Longshou Shan suggest that bivergent subduction of Qilian oceanic lithosphere occurred during the early Paleozoic. Crustal shortening and thickening during Ordovician–Carboniferous orogenesis are evidenced by the presence of several unconformities in the Longshou Shan. Late Carboniferous arc granites exposed in the study area are likely associated with the southward subduction of the Paleo-Asian Ocean to the north and with Permian siliciclastic strata sourced from a proximal arc-subduction system, based on detrital zircon ages. Although the tectonic history of the Longshou Shan can be traced back to Neoproterozoic time, most of the recorded deformation and uplift of the region occurred during the early Paleozoic Qilian orogeny and late Paleozoic Central Asian orogeny. Furthermore, we interpret that the several orogenic events recorded in the Longshou Shan (i.e., northern North China, Qilian, and Central Asian orogenies) are spatially and temporally correlative along strike with those recorded in the Tarim and North China cratons.
How often should percutaneous gastrostomy feeding tubes be replaced? A single-institute retrospective study
Authors: Cha Byung Hyo , Park Min Jung , Baeg Joo Yeong , Lee Sunpyo , Jeon Eui Yong , Alsalami Wafaa Salem Obaid , Idris Osama Mohamed Ibrahim , Ahn Young Joon 
Published: April 2022

ObjectivePercutaneous gastrostomy (PG) is a common procedure that enables long-term enteral nutrition. However, data on the durability of individual tube types are insufficient. We conducted this study to compare the longevities and features of different PG tube types.DesignWe performed a 5-year retrospective analysis of patients who underwent endoscopic and radiologic PG-related feeding tube procedures. The primary and secondary outcomes were tube exchange intervals and revenue costs, respectively. Demographic factors, underlying diseases, operator expertise, materials used, and complication profiles were assessed.ResultsA total of 599 PG-related procedures for inserting pull-type PG (PGP), balloon-type PG (PGB), PG jejunal MIC* (PGJM; gastrojejunostomy type), and PG jejunal Levin (PGJL) tubes were assessed. On univariate Kaplan-Meier analysis, PGP tubes showed longer median exchange intervals than PGB tubes (405 days (95% CI: 315 to 537) vs 210 days (95% CI: 188 to 238); p<0.001). Larger PGB tubes diameters were associated with longer durations than smaller counterparts (24 Fr: 262 days (95% CI: 201 to NA), 20 Fr: 216 days (95% CI: 189 to 239), and 18 Fr: 148 days (95% CI: 100 to 245)). The PGJL tubes lasted longer than PGJM counterparts (median durations: 168 days (95% CI: 72 to 372) vs 13 days (95% CI: 23 to 65); p<0.001). Multivariate Cox proportional regression analysis revealed that PGJL tubes had significantly lower failure rates than PGJM tubes (OR 2.97 (95% CI: 1.17 to 7.53); p=0.022). PGB tube insertion by general practitioners was the least costly, while PGP tube insertion by endoscopists was 2.9-fold more expensive; endoscopic PGJM tubes were the most expensive at two times the cost of PGJL tubes.ConclusionPGP tubes require replacement less often than PGB tubes, but the latter are more cost-effective. Moreover, PGJL tubes last longer than PGJM counterparts and, owing to lower failure rates, may be more suitable for high-risk patients.