bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFL Learners' Receptive Knowledge of Derived Words: The Case of Swedish Adolescents
Authors: Snoder Per , Laufer Batia 
Published: January 2022

AbstractThe study investigated how well Swedish adolescents recognize the meaning of derived words in English and whether this knowledge is determined by learner proficiency, word frequency, or affix type. Participants were 88 school students in two proficiency groups: 39 advanced 12th graders and 49 intermediate 9th graders. Two tests of receptive vocabulary knowledge were administered. The first test had 80 basewords (e.g., maintain) representing the 8,000 most frequent words. The second test had 60 words that were derived from the first test (e.g., maintainable). Results showed that participants’ knowledge of basewords extended to knowledge of derived words quite well: for example, when the advanced learners knew a baseword, they knew its derived form in 91% of the cases. Other results were that word family frequency but not derived word frequency determined knowledge of derived words, and that little support was found for Bauer and Nation’s (1993) hierarchy of affix difficulty. The main implication of the results is that the word family, which subsumes basewords and their related forms under word knowledge, is an appropriate unit of counting in L2 pedagogy and research for learners with extensive exposure to English and a Germanic first language.
Nickel oxide nanoparticles induce apoptosis and ferroptosis in airway epithelial cells via ATF3
Authors: Liu Fengfan , Cheng Xiang , Wu Shuang , Hu Bei , Yang Chen , Deng Shufen , Shi Qiwen 
Published: January 2022

AbstractExposure to nickel oxide nanoparticles (NiONPs), which have been widely produced and applied in industry, leads to adverse pulmonary and systemic effects. The aim of this study is to investigate the involvement of apoptosis and ferroptosis in NiONPs‐induced acute lung injury (ALI). Intratracheal instillation of NiONPs into mice elevated the levels of pro‐inflammatory cytokines, neutrophils, and proteins in the bronchoalveolar lavage fluid, and triggered apoptosis and ferroptosis in the lung tissues. Consistently, NiONPs‐induced apoptosis and ferroptosis were observed in in vitro experiments using human lung epithelial cells. Activating transcription factor 3 (ATF3), a stress‐inducible transcription factor, was upregulated by NiONPs exposure in both murine lung tissues and human lung epithelial cells. Moreover, human lung epithelial cells with ATF3 deficiency exhibited a lower level of apoptosis and ferroptosis when exposed to NiONPs. Collectively, our findings demonstrated that ATF3 was responsive to NiONPs exposure, and promoted NiONPs‐induced apoptosis and ferroptosis in lung epithelial cells, indicating that ATF3 is a potential biomarker and therapeutic target for NiONPs‐associated ALI.
Review of energy‐dispersive X‐ray fluorescence on food elements detection
Authors: Li Fei , Meng Lu , Ding Wenwan , Wang Jiamei , Ge Liangquan 
Published: January 2022

AbstractEnergy‐dispersive X‐ray fluorescence (EDXRF) is a physical rapid detection method to analyze the types of elements through the energy characteristics of fluorescent X‐ray particles. When applied to the detection of food element content, it not only needs simple sample pretreatment but also the element measurement time generally does not exceed 10 min to have the accuracy of μg/g, which can greatly reduce the time and cost of detection. Due to the limitations of the EDXRF instrument and measurement mechanism, it has low sensitivity to light elements in food, and the detection sensitivity varies with elements in food element analysis. For example, the detection sensitivity of Ca, Mg, Fe, Zn, Cu and other elements concerned by people is not high when the content is low, and the measurement accuracy is extremely dependent on the detector resolution. However, with the improvement of detector performance and algorithm optimization of EDXRF, the detection limit of this technology can reach 0.1 μg/g, the detection of trace elements has also been improved, which has made a new breakthrough in the field of food element detection. Therefore, this paper reviews that in recent 20 years, in order to overcome the various difficulties of EDXRF in food detection, the hardware optimization of EDXRF (For example, the development of an analyzer without sample preparation can greatly reduce the time required for the detection of food elements, and a series of instruments combined with EDXRF and cluster capillary technology can greatly improve the excitation efficiency of lighter elements in food. The spectrometer with a high‐resolution detector can improve the detection accuracy of target elements with low content in food) and in order to solve the problem of spectrum resolution in food detection, (For example, the wavelet transform method which has good performance in spectrum smoothing, identifying weak peaks and maintaining peak shape is applied to EDXRF spectrum resolution, which can better solve the problem that the X‐ray characteristic peaks of elements with a low atomic number in food are submerged) the reform and innovation of spectrum resolution methods are introduced. This paper summarizes and analyzes the representative application examples of EDXRF in food safety detection, discusses the advantages and disadvantages of EDXRF compared with other rapid detection or food detection methods in different situations, concludes its application conditions, and discusses the application prospect of EDXRF technology in the field of food detection.
Two-loop rational terms for spontaneously broken theories
Authors: Lang Jean-Nicolas , Pozzorini Stefano , Zhang Hantian , Zoller Max F. 
Published: January 2022

Abstract
Rational counterterms are a key ingredient for the automation of loop calculations through numerical methods. Building on the recently established properties of rational terms of UV origin at two loops, in this paper we present a systematic method for the determination of rational counterterms within spontaneously broken theories. In particular we introduce a generalised vev-expansion approach that makes it possible to obtain the rational counterterms of UV origin for a spontaneously broken theory by means of calculations in the unbroken phase. The drastic simplifications that result from the underlying symmetry open the door to the efficient determination of rational counterterms for the full Standard Model at two loops. The renormalisation-scheme dependence is analysed in detail, and we show that rational counterterms need to be determined only once and for all in a generic renormalisation scheme for the symmetric phase and, a posteriori, they can be easily adapted to a wide range of physical renormalisation schemes for the spontaneously broken phase. As a first application we determine the full set of $$ \mathcal{O}\left({\alpha}_{\mathrm{S}}^2\right) $$
O

α
S
2

rational counterterms of UV origin for the full Standard Model, i.e. for all superficially UV-divergent two-loop vertex functions involving combinations of gluons, quarks, electroweak vector bosons and scalar bosons.
Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRβ and affect PDGF-BB-induced STAT3 signalling
Authors: Sarri Niki , Wang Kehuan , Tsioumpekou Maria , Castillejo-López Casimiro , Lennartsson Johan , Heldin Carl-Henrik , Papadopoulos Natalia 
Published: January 2022

AbstractInteraction of platelet-derived growth factor (PDGF) isoforms with their receptors results in activation and internalization of receptors, with a concomitant activation of downstream signalling pathways. Ubiquitination of PDGFRs serves as a mark to direct the internalization and sorting of the receptors. By overexpressing a panel of deubiquitinating enzymes (DUBs), we found that USP17 and USP4 efficiently deubiquitinate PDGF receptor β (PDGFRβ) and are able to remove both Lys63 and Lys48-linked polyubiquitin chains from the receptor. Deubiquitination of PDGFRβ did not affect its stability, but regulated the timing of its trafficking, whereby USP17 prolonged the presence of the receptor at the cell surface, while USP4 affected the speed of trafficking towards early endosomes. Induction of each of the DUBs in BJhTERT fibroblasts and U2OS osteosarcoma cells led to prolonged and/or shifted activation of STAT3 in response to PDGF-BB stimulation, which in turn led to increased transcriptional activity of STAT3. Induction of USP17 promoted acute upregulation of the mRNA expression of STAT3-inducible genes STAT3, CSF1, junB and c-myc, while causing long-term changes in the expression of myc and CDKN1A. Deletion of USP17 was lethal to fibroblasts, while deletion of USP4 led to a decreased proliferative response to stimulation by PDGF-BB. Thus, USP17- and USP4-mediated changes in ubiquitination of PDFGRβ lead to dysregulated signalling and transcription downstream of STAT3, resulting in defects in the control of cell proliferation.
Hindman’s theorem for sums along the full binary tree, $$\Sigma ^0_2$$-induction and the Pigeonhole principle for trees
Authors: Carlucci Lorenzo , Tavernelli Daniele 
Published: January 2022

AbstractWe formulate a restriction of Hindman’s Finite Sums Theorem in which monochromaticity is required only for sums corresponding to rooted finite paths in the full binary tree. We show that the resulting principle is equivalent to$$\Sigma ^0_2$$Σ20-induction over$$\mathsf {RCA}_0$$RCA0. The proof uses the equivalence of this Hindman-type theorem with the Pigeonhole Principle for trees$${\mathsf {T}\,}{\mathsf {T}}^1$$TT1with an extra condition on the solution tree.
Gold nanoparticle formation as an indicator of enzymatic methods: colorimetric l-phenylalanine determination
Authors: Martín-Barreiro Alba , de Marcos Susana , Galbán Javier 
Published: January 2022

Abstract An enzymatic-colorimetric method has been developed based on the reaction between l-phenylalanine (l-Phe) and the l-amino acid oxidase (LAAO) in the presence of Au(III), which has led to the formation of gold nanoparticles. The intensity of the localized surface plasmon resonance (LSPR) band of the generated nanoparticles (550 nm) can be related to the concentration of l-Phe in the sample. The mechanism of the LAAO-l-Phe enzyme reaction in the presence of Au(III) has been studied through the evaluation and optimization of experimental conditions. These studies have reinforced the hypothesis that the catalytic center of the enzyme helps the Au(III) reduction and, thanks to the protein, the Au0 form is stabilized as gold nanoparticles (AuNPs). In the calibration study, a sigmoidal relationship between the concentration of the substrate and the LSPR of the nanoparticles was observed. The linearization of the signal has allowed the determination of l-Phe in the range from 17 to 500 µM with an RSD% (150 μM) of 4.8% (n = 3). The method is free of other amino acid interference normally found in blood plasma. These highly competitive results open the possibility of further development of a rapid method for l-Phe determination based on colorimetry.
Graphical abstract
Medication adherence among persons with coronary heart disease and associations with blood pressure and low-density-lipoprotein-cholesterol
Authors: Pedersen Elisabeth , Primicerio Raul , Halvorsen Kjell H. , Eggen Anne Elise , Garcia Beate Hennie , Schirmer Henrik , Waaseth Marit 
Published: January 2022

Abstract
Purpose
To describe medication adherence to lipid-lowering drugs (LLDs), antihypertensive drugs, and acetylsalicylic acid (ASA) among persons with coronary heart disease (CHD) and explore its association with low-density-lipoprotein (LDL)-cholesterol, and systolic and diastolic blood pressure.

Methods
Based on record linkage between the seventh wave of the Tromsø Study and the Norwegian Prescription Database, medication adherence was calculated as the proportion of days covered (PDC) for persistent prevalent users in the period of 365 days before the attendance date. Multivariable linear regression models were used to assess the association between systolic and diastolic blood pressure and medication nonadherence to antihypertensive drugs, age, sex, lifestyle, body mass index (BMI), current and previous diabetes, and between LDL-cholesterol and medication nonadherence to LLDs, age, sex, lifestyle, BMI, and current and previous diabetes.

Results
Mean PDC was 0.94 for LLDs and antihypertensive drugs and 0.97 for ASA. Among persons with PDC ≥ 0.80 for LLDs, 12.0% had an LDL-cholesterol < 1.8 mmol/L. Blood pressure < 140/90 mmHg (< 140/80 mmHg if diabetes patient) was reached by 55.1% of those with a PDC ≥ 0.80 for antihypertensive drugs. Adherence to LLDs was associated with lower LDL-cholesterol, while neither systolic nor diastolic blood pressure was associated with adherence to antihypertensive drugs.

Conclusion
Adherence to antihypertensive drugs, LLDs, and ASA among persons with CHD were high despite low achievement of treatment goals for blood pressure and LDL-cholesterol. There was a statistically significant association between adherence to LLDs and LDL-cholesterol, but not between adherence to antihypertensive drugs and blood pressure.
Feasibility of contrast-enhanced ultrasound and flank position during percutaneous nephrolithotomy in patients with no apparent hydronephrosis: a randomized controlled trial
Authors: Liu Zeng-Qin , Xie Jing , Zhao Chu-Biao , Liu Yan-Feng , Li Zai-Shang , Guo Ji-Nan , Jiang Hong-Tao , Xiao Ke-Feng 
Published: January 2022

AbstractPurposeTo investigate the puncture accuracy and feasibility of contrast-enhanced ultrasound (CEUS) guided percutaneous nephrolithotomy (PCNL) in flank position for patients with no apparent hydronephrosis.MethodsBetween May 2018 and June 2020, 72 kidney stone patients with no or mild hydronephrosis were randomized into two groups: a CEUS-guided PCNL group and a conventional ultrasound (US)-guided group. Patients’ demographics and perioperative outcomes were compared, including the success rate of puncture via calyceal fornix, the success rate of a single-needle puncture, puncture time, operative time, postoperative hemoglobin loss, stone-free rate, incidence of complications and postoperative stay.ResultsThe success rate of puncture via calyceal fornix for CEUS-guided group was significantly higher than that for conventional US-guided group (86.1 vs. 47.2%,p = 0.002). Patients performed with CEUS-guided PCNL required shorter renal puncture time than those guided with conventional US (36.5 s vs. 61.0 s,p < 0.001). The median postoperative hemoglobin loss in the CEUS-guided group was significantly lower than that in conventional US-guided group (2.5 vs. 14.5 g/L,p < 0.01). There was no statistically significant difference in the success rate of a single-needle puncture, operative time, stone-free rate, incidence of complications and postoperative stay between the two groups.ConclusionCEUS guidance facilitates identification of the renal calyx fornix, and benefits more precise renal puncture and less hemoglobin loss in PCNL. CEUS-guided PCNL in flank position is a feasible approach to the treatment of kidney stone patients with no apparent hydronephrosis.Trial registration number: ChiCTR1800015417.
A meta-analysis of survival after minimally invasive radical hysterectomy versus abdominal radical hysterectomy in cervical cancer: center-associated factors matter
Authors: Sun Si , Cai Jing , Li Ruixie , Wang Yujia , Zhao Jing , Huang Yuhui , Xu Linjuan , Yang Qiang , Wang Zehua 
Published: January 2022

Abstract
Purpose
To explore the possible factors that contributed to the poor performance of minimally invasive surgery (MIS) versus abdominal surgery regarding progression-free survival (PFS) and overall survival (OS) in cervical cancer.

Methods
MEDLINE, EMBASE, Cochrane Library and Web of Science were searched (January 2000 to April 2021). Study selection was performed by two researchers to include studies reported oncological safety. Summary hazard ratios (HRs) and 95% confidence intervals (CIs) were combined using random-effect model. Subgroup analyses were stratified by characteristics of disease, publication, study design and treatment center.

Results
Sixty-one studies with 63,369 patients (MIS 26956 and ARH 36,049) were included. The overall-analysis revealed a higher risk of recurrence (HR 1.209; 95% CI 1.102–1.327) and death (HR 1.124; 95% CI 1.013–1.248) after MIS versus ARH expect in FIGO IB1 (FIGO 2009 staging) patients with tumor size less than 2 cm. However, subgroup analyses showed comparable PFS/DFS and OS in studies published before the Laparoscopic Approach to Cervical Cancer (LACC) trial, published in European journals, conducted in a single center, performed in centers in Europe and in centers with high sample volume or high MIS sample volume.

Conclusion
Our findings highlight possible factors that associated with inferior survival after MIS in cervical cancer including publication characteristics, center-geography and sample volume. Center associated factors were needed to be taken into consideration when evaluating complex surgical procedures like radical hysterectomy.
NucPosDB: a database of nucleosome positioning in vivo and nucleosomics of cell-free DNA
Authors: Shtumpf Mariya , Piroeva Kristan V. , Agrawal Shivam P. , Jacob Divya R. , Teif Vladimir B. 
Published: January 2022

AbstractNucleosome positioning is involved in many gene regulatory processes happening in the cell, and it may change as cells differentiate or respond to the changing microenvironment in a healthy or diseased organism. One important implication of nucleosome positioning in clinical epigenetics is its use in the “nucleosomics” analysis of cell-free DNA (cfDNA) for the purpose of patient diagnostics in liquid biopsies. The rationale for this is that the apoptotic nucleases that digest chromatin of the dying cells mostly cut DNA between nucleosomes. Thus, the short pieces of DNA in body fluids reflect the positions of nucleosomes in the cells of origin. Here, we report a systematic nucleosomics database — NucPosDB — curating published nucleosome positioning datasets in vivo as well as datasets of sequenced cell-free DNA (cfDNA) that reflect nucleosome positioning in situ in the cells of origin. Users can select subsets of the database by a number of criteria and then obtain raw or processed data. NucPosDB also reports the originally determined regions with stable nucleosome occupancy across several individuals with a given condition. An additional section provides a catalogue of computational tools for the analysis of nucleosome positioning or cfDNA experiments and theoretical algorithms for the prediction of nucleosome positioning preferences from DNA sequence. We provide an overview of the field, describe the structure of the database in this context, and demonstrate data variability using examples of different medical conditions. NucPosDB is useful both for the analysis of fundamental gene regulation processes and the training of computational models for patient diagnostics based on cfDNA. The database currently curates ~ 400 publications on nucleosome positioning in cell lines and in situ as well as cfDNA from > 10,000 patients and healthy volunteers. For open-access cfDNA datasets as well as key MNase-seq datasets in human cells, NucPosDB allows downloading processed mapped data in addition to the regions with stable nucleosome occupancy. NucPosDB is available at https://generegulation.org/nucposdb/.
Rapid and sensitive identification of omicron by variant-specific PCR and nanopore sequencing: paradigm for diagnostics of emerging SARS-CoV-2 variants
Authors: Dächert Christopher , Muenchhoff Maximilian , Graf Alexander , Autenrieth Hanna , Bender Sabine , Mairhofer Helga , Wratil Paul R. , Thieme Susanne , Krebs Stefan , Grzimek-Koschewa Natascha , Blum Helmut , Keppler Oliver T. 
Published: January 2022

AbstractOn November 26, 2021, the World Health Organization classified B.1.1.529 as a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VoC), named omicron.Spike-gene dropouts in conventional SARS-CoV-2 PCR systems have been reported over the last weeks as indirect diagnostic evidence for the identification of omicron. Here, we report the combination of PCRs specific for heavily mutated sites in thespikegene and nanopore-based full-length genome sequencing for the rapid and sensitive identification of the first four COVID-19 patients diagnosed in Germany to be infected with omicron on November 28, 2021. This study will assist the unambiguous laboratory-based diagnosis and global surveillance for this highly contagious VoC with an unprecedented degree of humoral immune escape. Moreover, we propose that specialized diagnostic laboratories should continuously update their assays for variant-specific PCRs in thespikegene of SARS-CoV-2 to readily detect and diagnose emerging variants of interest and VoCs. The combination with established nanopore sequencing procedures allows both the rapid confirmation by whole genome sequencing as well as the sensitive identification of newly emerging variants of this pandemic β-coronavirus in years to come.
Feasibility and acceptability of virtual reality for cancer pain in people receiving palliative care: a randomised cross-over study
Authors: Austin Philip D. , Siddall Philip J. , Lovell Melanie R. 
Published: January 2022

Abstract
Context
Pain management in palliative care remains inadequate; the development of innovative therapeutic options is needed.

Objectives
To determine the feasibility and preliminary effectiveness for larger randomised controlled trials of 3D head-mounted (HMD) virtual reality (VR) for managing cancer pain (CP) in adults.

Methods
Thirteen people receiving palliative care participated in a single-session randomised cross-over trial, after which they completed a qualitative semi-structured interview. We also compared the effects of 3D HMD VR and 2D screen applications on CP intensity and levels of perceived presence. Feasibility was assessed with recruitment, completion rates and time required to recruit target sample.

Results
Although recruitment was slow, completion rate was high (93%). Participants reported that the intervention was acceptable and caused few side effects. Although participants reported significantly reduced CP intensity after 3D HMD VR (1.9 ± 1.8, P = .003) and 2D screen applications (1.5 ± 1.6, P = .007), no significant differences were found between interventions (−.38 ± 1.2, 95% CI: −1.1–.29, P = .23). Participants reported significantly higher levels of presence with the 3D HMD VR compared to 2D screen (60.7 ± SD 12.4 versus 34.3 ± SD 17.1, mean 95% CI: 16.4–40.7, P = .001). Increased presence was associated with significantly lower pain intensity (mean 95% CI: −.04–−0.01, P = 0.02).

Conclusions
Our preliminary findings support growing evidence that both 3D and 2D virtual applications provide pain relief for people receiving palliative care. Given the relative lack of cybersickness and increasing access to portable VR, we suggest that larger clinical studies are warranted.
SaBRe: load-time selective binary rewriting
Authors: Arras Paul-Antoine , Andronidis Anastasios , Pina Luís , Mituzas Karolis , Shu Qianyi , Grumberg Daniel , Cadar Cristian 
Published: January 2022

AbstractBinary rewriting consists in disassembling a program to modify its instructions. However, existing solutions suffer from shortcomings in terms of soundness and performance. We present SaBRe, a load-time system for selective binary rewriting. SaBRe rewrites specific constructs—particularly system calls and functions—when the program is loaded into memory, and intercepts them using plugins through a simple API. We also discuss the theoretical underpinnings of disassembling and rewriting. We developed two backends—for and —which were used to implement three plugins: a fast system call tracer, a multi-version executor, and a fault injector. Our evaluation shows that SaBRe imposes little overhead, typically below 3%.