bluuebunny/crossref_metadata_2025_split huggingface dataset:
A retrospective, descriptive study of hepatitis C testing, prevalence, and care continuum among adults on probation
Authors: Kamis Kevin F. , Wyles David L. , Minturn Matthew S. , Scott Tracy , McEwen Dean , Hurley Hermione , Prendergast Scott J. , Gunter Jessie , Rowan Sarah E. 
Published: August 2022

Abstract
Background
Despite constituting the largest segment of the correctional population, individuals on court-ordered probation remain largely unstudied with respect to hepatitis C virus (HCV) testing and linkage-to-care. We conducted a retrospective, descriptive analysis to estimate prevalence of diagnosed HCV and the subsequent HCV care cascade among a cohort of individuals enrolled in an adult probation program over a 25-month period in Denver, Colorado.

Methods
We utilized probabilistic matching with first and last name, sex, and birthdate to identify individuals enrolled in probation between July 1, 2016 and July 30, 2018 who had a medical record at the participating safety-net healthcare institution as of December 31, 2019. Electronic medical record data were queried for evidence of HCV testing and care through June 30, 2021. The state HCV registry was also queried for prevalence of reported HCV cases among the cohort.

Results
This cohort included 8,903 individuals; 6,920 (78%) individuals had a medical record at the participating institution, and of these, 1,037 (15%) had ever been tested for HCV (Ab or RNA) and 308 (4% of those with a medical record, 30% of those tested) had detectable HCV RNA. Of these, 105 (34%) initiated HCV treatment, 89 (29%) had a subsequent undetectable HCV viral load, and 65 (21%) had documentation of HCV cure. Eleven percent of the total cohort had records of positive HCV Ab or RNA tests in the state HCV registry.

Conclusions
This study demonstrates the importance of HCV screening and linkage-to-care for individuals enrolled in probation programs. A focus on this population could enhance progress towards HCV elimination goals.
Non-ambulatory pigs in two Brazilian growing-finishing farms: a clinic, etiological and pathological perspective on 76 cases
Authors: Piva Manoela Marchezan , Schwertz Claiton I. , Henker Luan Cleber , Bianchi Ronaldo Michel , Kemper Regina Tose , de Almeida Bruno Albuquerque , Nagae Ricardo Yuiti , Michaelsen Taís Regina , Pavarini Saulo Petinatti 
Published: August 2022

Abstract
Background
Non-ambulatory pigs, colloquially known as downers or downed pigs, are animals presented with limited to no mobility, usually as a result of pre-existing neurologic or musculoskeletal conditions. Impaired ambulation is a major cause of euthanasia in pigs, leading to economic losses and animal welfare concerns. Additionally, reaching the underlying diagnosis of impaired ambulation in pigs is commonly a challenging task for swine practitioners. The aim of this necropsy-based study was to report the clinical, etiological, and pathological findings of 76 non-ambulatory grower-finisher pigs, and to correlate tail-biting lesions with the causes of death/reason for euthanasia in non-ambulatory pigs. Necropsies of downed pigs were performed during on-site visits to two pig farms in southern Brazil.

Results
The diagnosis of the conditions was based on the clinical, macroscopic, histopathological, bacteriological, immunohistochemical, and molecular findings. The diseases diagnosed in non-ambulatory pigs in this study were suppurative arthritis (29/76), suppurative spondylitis (10/76), PVC-2 associated diseases (8/76), bone fracture (7/76), non-suppurative meningoencephalomyelitis (4/76), suppurative meningoencephalitis (6/76), fibrocartilaginous thromboembolism (3/76), epiphysiolysis (3/76), ascending bacterial myelitis (3/76), and other conditions (3/76). The frequency of suppurative arthritis, suppurative spondylitis, and ascending bacterial myelitis/meningitis was higher in pigs with tail biting lesions than controls (P < 0.001).

Conclusions
Non-ambulatory pigs were observed during the entire rearing period, however, the occurrence of non-ambulatory pigs increased in animals aged ≥ 150 days. Infectious diseases were the most common cause of downed pigs, mainly associated with chronic bacterial infections. Tail biting lesions were an important predisposing factor to suppurative arthritis, suppurative spondylitis, and ascending bacterial myelitis/meningitis.
Machine learning based personalized promotion strategy of piglets weaned per sow per year in large-scale pig farms
Authors: Zhou Xingdong , Guan Ran , Cai Hongbo , Wang Pei , Yang Yongchun , Wang Xiaodu , Li Xiaowen , Song Houhui 
Published: August 2022

Abstract
Background
The purpose of this study was to analyze the relationship between different productive factors and piglets weaned per sow per year (PSY) in 291 large-scale pig farms and analyze the impact of the changes in different factors on PSY. We chose nine different algorithm models based on machine learning to calculate the influence of each variable on every farm according to its current situation, leading to personalize the improvement of the impact in the specific circumstances of each farm, proposing a production guidance plan of PSY improvement for every farm. According to the comparison of mean absolute error (MAE), 95% confidence interval (CI) and R2, the optimal solution was conducted to calculate the influence of 17 production factors of each pig farm on PSY improvement, finding out the bottleneck corresponding to each pig farm. The level of PSY was further analyzed when the bottleneck factor of each pig farm changed by 0.5 standard deviation (SD).

Results
17 production factors were non-linearly related to PSY. The top five production factors with the highest correlation with PSY were the number of weaned piglets per litter (WPL) (0.6694), mating rate within 7 days after weaning (MR7DW) (0.6606), number of piglets born alive per litter (PBAL) (0.6517), the total number of piglets per litter (TPL) (0.5706) and non-productive days (NPD) (− 0.5308). Among nine algorithm models, the gradient boosting regressor model had the highest R2, smallest MAE and 95% CI, applied for personalized analysis. When one of 17 production factors of 291 large-scale pig farms changed by 0.5 SD, 101 pig farms (34.7%) can increase 1.41 PSY (compared to its original value) on average by adding the production days, and 60 pig farms (20.6%) can increase 1.14 PSY on average by improving WPL, 45 pig farms (15.5%) can increase 1.63 PSY by lifting MR7DW.

Conclusions
The main productive factors related to PSY included WPL, MR7DW, PBAL, TPL and NPD. The gradient boosting regressor model was the optimal method to individually analyze productive factors that are non-linearly related to PSY.
Study protocol for the evaluation of Fear-Less: a stepped-care program for fear of cancer recurrence in survivors with early-stage disease
Authors: Tran Mei Jun , Jefford Michael , Smith Ben , Lynch Fiona , Dhillon Haryana M. , Shaw Joanne , McDowell Lachlan , White Alan , Halloran Clare , Wiesenfeld David , Ftanou Maria 
Published: August 2022

Abstract
Background
Fear of cancer recurrence (FCR) is a significant unmet need amongst cancer survivors and is consistently associated with psychological distress and impaired quality of life. Psychological interventions for FCR, such as ConquerFear, have demonstrated efficacy in reducing FCR and improving emotional wellbeing. Unfortunately, there are barriers to the uptake of evidence-based FCR treatments in clinical practice. A stepped-care FCR treatment model may overcome these barriers and has demonstrated potential in people with advanced melanoma. This study aims to evaluate the acceptability, feasibility, and impact of a stepped-care FCR treatment model (Fear-Less) in people with other cancer types, who have completed treatment with curative intent.

Methods
Sixty people with early-stage cancer (defined as individuals who have received treatment with curative intent and with no metastatic disease) will be screened for FCR using the Fear of Cancer Recurrence Inventory—Short Form (FCRI-SF). Individuals reporting moderate FCR (FCRI-SF between 13 and 21) will be offered a clinician-guided self-management resource; those reporting high FCR (FCRI-SF ≥ 22) will be offered individual therapy according to the ConquerFear protocol. Participants will complete purpose-built evaluation surveys assessing their FCR screening and intervention experiences. Clinicians will also complete a survey regarding their experiences of the treatment model. Fear-Less will be evaluated in terms of (1) acceptability (i.e., patient and clinician experience), (2) feasibility (i.e., referral uptake, treatment adherence, and time taken to screen and deliver interventions), and (3) impact (i.e., pre- to post-intervention FCR changes).

Discussion
The Fear-Less stepped-care model is a novel framework for screening FCR and stratifying survivors to the appropriate level of treatment. Our study will provide an indication of whether Fear-Less is a feasible and acceptable FCR model of care amongst survivors with early-stage disease and inform further investigations of this model.

Trial registration
Australian New Zealand Clinical Trials Registry (ANZCTR); ACTRN12622000818730.
Bi-level optimization based two-stage market clearing model considering guaranteed accommodation of renewable energy generation
Authors: He Qianya , Lin Zhenjia , Chen Haoyong , Dai Xinyun , Li Yirui , Zeng Xin 
Published: August 2022

AbstractThe existing electricity market mechanisms designed to promote the consumption of renewable energy generation complicate network participation in market transactions owing to an unfair market competition environment, where the low cost renewable energy generation is not reflected in the high bidding price of high cost conventional energy generation. This study addresses this issue by proposing a bi-level optimization based two-stage market clearing model that considers the bidding strategies of market players, and guarantees the accommodation of renewable energy generation. The first stage implements a dual-market clearing mechanism that includes a unified market for trading the power generations of both renewable energy and conventional energy units, and a subsidy market reserved exclusively for conventional generation units. A re-adjustment clearing mechanism is then proposed in the second stage to accommodate the power generation of remaining renewable energy units after first stage energy allocations. Each stage of the proposed model is further described as a bi-level market equilibrium problem and is solved using a co-evolutionary algorithm. Finally, numerical results involving an improved IEEE 39-bus system demonstrate that the proposed two-stage model meets the basic requirements of incentive compatibility and individual rationality. It can facilitate the rational allocation of resources, promote the economical operation of electric power grids, and enhance social welfare.
Technical and technological constraints facing Tanzania leather value chain: a snapshot of intervention measures
Authors: China Cecilia Rolence , Elibariki Rahel , Msami Jamal , Mwombela Stephen , Wilson Lugano 
Published: August 2022

AbstractThe leather value chain starts with livestock, the key source of hides and skins, and the main raw materials for the industry. Despite having the second-largest livestock population in Africa, Tanzania is only the 11th largest exporter of leather on the continent, underlining the disproportionate contribution of the sector to the economy. This study presents the results of a recent assessment aimed at identifying performance bottlenecks in Tanzania's leather sector. The assessment took place in October–December 2020 and involved 10 tanneries, 30 leather goods factories and 11 service providers/institutions. Findings reveal that 90% of tanneries are dissatisfied with the quality of hides and skins due to brand marks, flay cuts, skin diseases, and inadequate curing. These supply chain bottlenecks are further compounded by skill deficiencies among processors, poor waste management, and limited awareness about laws, policies and regulations governing trade in the sector. At the downstream end of the value chain, the trade in leather and related articles is facing competition from high importation of low-grade products like plastic shoes and second-hand products. This paper recommends that efforts to increase leather's economic and trade value need to focus on upgrading Tanzania’s production, processing, branding and marketing capacities.
Graphical Abstract
Functional progressive resistance exercise versus eccentric muscle control in children with hemiplegia: a randomized controlled trial
Authors: Soliman Yosra Magdy , Eltohamy Amira Mohamed , Ayad Mona Nabil 
Published: August 2022

Abstract
Background
Historically, strength exercise in children with CP is not recommended, because it may develop spasticity, which results in difficulty with walking. But, recently increasing studies and systemic reviews have reported that strength exercise can promote muscle strength in children with CP with no negative impact on spasticity. The study is aiming to compare the effect of functional resistance exercise and functional eccentric training on dynamic balance and functional ability in children with hemiplegia. For this purpose, forty participating children diagnosed with spastic hemiplegia were included and their ages ranged from 6 to 13 years. They were randomly allocated into two groups: functional resistance exercise (group I) or eccentric muscle control exercise (group II). The training was conducted three times a week for 6 weeks for both groups. Each group received one of the interventions in addition to designed physical therapy programs. Functional ability and dynamic balance were measured before and after 6 weeks of the intervention by gross motor function measure and functional reach test.

Results
Comparison between the two groups before treatment revealed no significant difference in all values of functional ability and dynamic balance. But comparison after treatment in values showed significant improvement in both groups with greater improvements in favor of group I (p < 0.01).

Conclusion
Adding both functional resistance exercise and eccentric muscle control exercise is beneficial for improving functional ability and dynamic balance with more recommendation for adding functional resistance exercise that showed more significant improvement than eccentric muscle control in children with hemiplegia.
Efficacy and moderators of cognitive therapy versus behavioural activation for adults with depression: study protocol of a systematic review and meta-analysis of individual participant data
Authors: Driessen Ellen , Cohen Zachary D. , Lorenzo-Luaces Lorenzo , Hollon Steven D. , Richards David A. , Dobson Keith S. , Dimidjian Sona , Delgadillo Jaime , Vázquez Fernando L. , McNamara Kathleen , Horan John J. , Gardner Pauline , Oei Tian P. , Mehta Anuj H. P. , Twisk Jos W. R. , Cristea Ioana A. , Cuijpers Pim 
Published: August 2022

Background
Cognitive therapy and behavioural activation are both widely applied and effective psychotherapies for depression, but it is unclear which works best for whom. Individual participant data (IPD) meta-analysis allows for examining moderators at the participant level and can provide more precise effect estimates than conventional meta-analysis, which is based on study-level data.

Aims
This article describes the protocol for a systematic review and IPD meta-analysis that aims to compare the efficacy of cognitive therapy and behavioural activation for adults with depression, and to explore moderators of treatment effect. (PROSPERO: CRD42022341602)

Method
Systematic literature searches will be conducted in PubMed, PsycINFO, EMBASE and the Cochrane Library, to identify randomised clinical trials comparing cognitive therapy and behavioural activation for adult acute-phase depression. Investigators of these trials will be invited to share their participant-level data. One-stage IPD meta-analyses will be conducted with mixed-effects models to assess treatment effects and to examine various available demographic, clinical and psychological participant characteristics as potential moderators. The primary outcome measure will be depressive symptom level at treatment completion. Secondary outcomes will include post-treatment anxiety, interpersonal functioning and quality of life, as well as follow-up outcomes.

Conclusions
To the best of our knowledge, this will be the first IPD meta-analysis concerning cognitive therapy versus behavioural activation for adult depression. This study has the potential to enhance our knowledge of depression treatment by using state-of-the-art statistical techniques to compare the efficacy of two widely used psychotherapies, and by shedding more light on which of these treatments might work best for whom.
Development and Validation of Risk Prediction Models for Coronary Heart Disease and Heart Failure After Treatment for Hodgkin Lymphoma
Authors: de Vries Simone , Haaksma Miriam L. , Jóźwiak Katarzyna , Schaapveld Michael , Hodgson David C. , Lugtenburg Pieternella J. , Krol Augustinus D.G. , Petersen Eefke J. , van Spronsen Dick Johan , Ahmed Sameera , Hauptmann Michael , Aleman Berthe M.P. , van Leeuwen Flora E. 
Published: August 2022

PURPOSE Previous efforts to predict absolute risk of treatment-related cardiovascular diseases (CVDs) have mostly focused on childhood cancer survivors. We aimed to develop prediction models for risk of coronary heart disease (CHD) and heart failure (HF) for survivors of adolescent/adult Hodgkin lymphoma (HL). METHODS For model development, we used a multicenter cohort including 1,433 5-year HL survivors treated between 1965 and 2000 and age 18-50 years at HL diagnosis, with complete data on administered chemotherapy regimens, radiotherapy volumes and doses, and cardiovascular follow-up. Using cause-specific hazard models, covariate-adjusted cumulative incidences for CHD and HF were estimated in the presence of competing risks of death because of other causes than CHD and HF. Age at HL diagnosis, sex, smoking status, radiotherapy, and anthracycline treatment were included as predictors. External validation for the CHD model was performed using a Canadian cohort of 708 HL survivors treated between 1988 and 2004 and age 18-50 years at HL diagnosis. RESULTS After a median follow-up of 24 years, 341 survivors had developed CHD and 102 had HF. We were able to predict CHD and HF risk at 20 and 30 years after treatment with moderate to good overall calibration and moderate discrimination (areas under the curve: 0.68-0.74), which was confirmed by external validation for the CHD model (areas under the curve: 0.73-0.74). On the basis of our model including prescribed mediastinal radiation dose, 30-year risks ranged from 4% to 78% for CHD and 3% to 46% for HF, depending on risk factors. CONCLUSION We developed and validated prediction models for CHD and HF with good overall calibration and moderate discrimination. These models can be used to identify HL survivors who might benefit from targeted screening for CVD and early treatment for CVD risk factors.
Six-Year Results From RELEVANCE: Lenalidomide Plus Rituximab (R2) Versus Rituximab-Chemotherapy Followed by Rituximab Maintenance in Untreated Advanced Follicular Lymphoma
Authors: Morschhauser Franck , Nastoupil Loretta , Feugier Pierre , Schiano de Colella Jean-Marc , Tilly Hervé , Palomba Maria Lia , Bachy Emmanuel , Fruchart Christophe , Libby Edward N. , Casasnovas Rene-Olivier , Flinn Ian W. , Haioun Corinne , Maisonneuve Hervé , Ysebaert Loic , Bartlett Nancy L. , Bouabdallah Kamal , Brice Pauline , Ribrag Vincent , Le Gouill Steven , Daguindau Nicolas , Guidez Stéphanie , Pica Gian Matteo , García-Sancho Alejandro Martín , López-Guillermo Armondo , Larouche Jean-François , Ando Kiyoshi , Gomes da Silva Maria , André Marc , Kalung Wu , Sehn Laurie H. , Izutsu Koji , Cartron Guillaume , Gkasiamis Argyrios , Crowe Russell , Xerri Luc , Fowler Nathan H. , Salles Gilles 
Published: August 2022

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. The RELEVANCE trial (ClinicalTrials.gov identifier: NCT01650701 ) showed that lenalidomide plus rituximab (R2) provided similar efficacy to rituximab plus chemotherapy (R-chemo) in patients with advanced-stage, previously untreated follicular lymphoma (FL). We report the second interim analysis of the RELEVANCE trial after 6 years of follow-up. Patients with previously untreated grade 1-3a FL were assigned 1:1 to R2 or R-chemo, followed by rituximab maintenance. Coprimary end points were complete response (confirmed/unconfirmed) at week 120 and progression-free survival (PFS). At median follow-up of 72 months, 6-year PFS was 60% and 59% for R2 and R-chemo, respectively (hazard ratio = 1.03 [95% CI, 0.84 to 1.27]). Six-year overall survival was estimated to be 89% in both groups. Median PFS and overall survival were not reached in either group. Overall response after progression was 61% and 59%, and 5-year estimated survival rate after progression was 69% and 74% in the R2 and R-chemo groups, respectively. The transformation rate per year in the R2 and R-chemo groups was 0.68% and 0.45%, and secondary primary malignancies occurred in 11% and 13% ( P = .34), respectively. No new safety signals were observed. R2 continues to demonstrate comparable, durable efficacy and safety versus R-chemo in previously untreated patients with FL and provides an acceptable chemo-free alternative.
Exercise to Treat Hypertension: Late Breaking News on Exercise Prescriptions That FITT
Authors: Alves Alberto J. , Wu Yin , Lopes Susana , Ribeiro Fernando , Pescatello Linda S. 
Published: August 2022

Abstract
Hypertension is the leading risk factor for cardiovascular disease and an independent predictor of mortality. The prevalence of hypertension has doubled in the last two decades and evidence suggests that almost half the individuals are unaware of their condition. The antihypertensive effects of exercise are now undisputable, and exercise training is recommended by the major professional and scientific societies, including the American College of Sports Medicine (ACSM), as first-line treatment to prevent, treat, and control hypertension. This review aims to overview the evidence supporting the current ACSM Frequency, Intensity, Time, and Type exercise recommendations for hypertension, discuss new and emerging evidence on exercise in the treatment of hypertension from our laboratories; and propose future directions of research integrating this new and emerging evidence.