bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tectonothermal Model for the Late Paleozoic Syncollisional Formation Stage of the Kara Orogen (Northern Taimyr, Central Arctic)
Authors: Vernikovsky V.A. , Polyansky O.P. , Babichev A.B. , Vernikovskaya A.E. , Proskurnin V.F. , Matushkin N.Yu. 
Published: May 2022

AbstractWe present a tectonothermal model for the late Paleozoic syncollisional formation stage of the Kara orogen in northern Taimyr in the Central Arctic. The model is based on new and published structural, petrological, geochemical, and geochronological data, as well as thermophysical properties obtained for the Kara orogen. The latter hosts a significant volume of granites formed as a result of the collision between the Kara microcontinent and the Siberian craton. Based on geological, geochemical, and U–Th–Pb isotope data, the granites were differentiated into syncollisional and postcollisional intrusions that were emplaced in the intervals 315–282 and 264–248 Ma, respectively. The presented tectonothermal model covers only the syncollisional formation stage of the Kara orogen, during which anatectic granites formed. The 2D models help to reconstruct the main tectonothermal processes of the syncollisional stage of formation of this structure, taking into account the local peculiarities of the thermal state of the Earth’s crust in the region. The model shows the mechanisms of increase in the lower crust temperature necessary for the formation of syncollisional anatectic granites. The estimates obtained from the model constrain the time interval between collision/tectonic stacking and the granite formation. The modeling also showed the general regularities typical for orogens on syncollisional stages.
A New Lithium Nickel Oxide Cathode Material with a Composite Structure for High-Performance Li-ion Batteries
Authors: Yao Junyi , Qi Jizhen , Dong Qingyu , Shen Yanbin , Chen Liwei , Liu Sizhan , Wang Yong , Li Linsen , Mao Qianlun , Yang Shiqi , Gao Lijun , Zhang Kun , Xu Kaihua , Wang Feng , Zhao Jianqing , Bai Jianming 
Published: May 2022

Abstract
Guided by in situ synchrotron X-ray diffraction (SXRD) measurements and quantitative analysis, we identified and synthesized a new type of lithium nickel oxide as a cathode material for Li-ion batteries. This compound is a composition of two crystallographic components: a major stoichiometric layer-structured phase, LiNiO2, and a minor Li-containing disordered rock-salt phase, LiδNi1-δO, both embedded in the same cubic close-packed oxygen lattice. The LiNiO2|LiδNi1-δO composite, when used as the active material in a cathode, delivers high energy density, superior rate capability, and long-term cycling stability owing to its unique structural configuration.
A kinome-wide CRISPR screen identifies CK1α as a novel target to overcome enzalutamide resistance of prostate cancer
Authors: LIU JINGHUI , Zhao Yue , He Daheng , Jones Katelyn , Tang Shan , Allison Derek , Zhang Yanquan , Chen Jing , Zhang Qiongsi , Wang Xinyi , Li Chaohao , Wang Chi , Li Lang , Liu Xiaoqi 
Published: May 2022

Abstract

Enzalutamide (ENZA), a second-generation androgen receptor antagonist, has significantly increased progression-free and overall survival of patients with metastatic prostate cancer (PCa). However, resistance remains a prominent obstacle in treatment, illustrating the urgent need to develop new approaches to increase ENZA efficacy. Utilizing a kinome-wide CRISPR-Cas9 knockout screen, we identified casein kinase 1 alpha (CK1α) as a novel therapeutic target to overcome ENZA resistance. Depletion or pharmacologic inhibition of CK1α significantly enhanced EZNA efficacy in ENZA-resistant cell lines and patient-derived xenografts. Mechanistically, CK1α phosphorylates the serine residue S1270 and modulates the protein abundance of ataxia-telangiectasia mutated (ATM), a primary initiator of DNA double-strand break (DSB)-response signaling, which is compromised in ENZA-resistant cells and patients. Inhibition of CK1α stabilizes ATM, resulting in the restoration of DSB-response signaling, and thus increases ENZA-induced cell death and growth arrest in an ATM-dependent manner. Our study details an innovative therapeutic approach for ENZA-resistant PCa and characterizes a novel perspective for the function of CK1α in the regulation of DNA damage response signaling.
The use of bacterial nanocellulose as wound healing dressing: a scoping review
Authors: Pittella Camila Quinetti Paes , Vitoria Edney Marcio , Mendes Micaela Faria , Coli Taciely Campana , Delage Mariana Domiciano , Junior Gesner Francisco Xavier , Santos Kelli Borges , Nascimento Thiago Cesar 
Published: May 2022

Abstract
Bacterial nanocellulose (BNC) is a nanofibrillar polymer produced by aerobic bacteria of the genus Gluconacetobacter. The use of BNC as a wound dressing is a novel biotechnology and unique strategy indicated for chronic and acute wound treatment as it has a set of features that will contribute to efficient skin recovery. Studies have reported that BNC can be more effective in healing capacity when compared to other wound dressings providing benefits for the patient and the health system. Our purpose was to summarize such clinical evidences bringing studies that could support the use of BNC as a dressing in many forms and its possibilities for the future. Methods: We conducted a scoping review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. Databases were searched for relevant articles without restriction about publication year or period. Inclusion criteria: Articles that report the use of BNC in the healing of acute or chronic wounds through clinical tests were included in the analysis. Articles that have performed preclinical tests (in vivo and in vitro) were excluded from the analysis. Results: We have found sixteen articles using the protocol criteria. The development of the present study made possible to evaluate the extent of clinical use of the BNC dressing, through available evidences on its use for the treatment of chronic and acute wounds. When analyzing the results, it became evident that BNC is a promising biotechnological resource for the effective healing of chronic and acute wounds.
WITHDRAWN: The Effect of Reduced Water Quality Variables on D issolved Oxygen Concentration Prediction Performance of Random Forest and Multilayer Perceptron Regressors
Authors: GARABAGHI FARID HASSANBAKI , Benzer Semra , Benzer Recep 
Published: May 2022

Abstract
That life highly depends on oxygen on the blue planet is an undeniable fact. Not only for preserving the ecosystem as well as aquatic organisms’ well-being, but sufficient amount of dissolved oxygen (DO) in water systems is also important from the sustainable drinking water resources point of view. Therefore, as important as monitoring DO concentrations in aquatic systems, accurate prediction of future levels of DO has become in the center of attention of many researchers as well as national and international agencies. One simple way to overcome this task is to get benefit from machine learning methods. This study was designed to evaluate the performance of random forest (RF) regressor against multilayer perceptron (MLP) as a popular model of artificial neural networks in predicting DO concentrations. More importantly, the effect of dimension reduction of the dataset by applying wrapper feature selection technique on the performance and accuracy of prediction of the regressors was also investigated. The results showed that RF regressor excelled MLP in performance with either of the datasets (the dataset of all parameters of interest and the dataset of reduced subset of features). Moreover, training the RF regressor with reduced subset of features positively affected the performance of the regressor, however, the accuracy of the MLP regressor declined considerably when it was trained with the dataset of reduced features. The results proved the positive impact of dimensionality reduction on the performance of RF regressor for predicting DO concentrations.
Effect of Electronic Cigarettes Smoking on Color Stability of CAD/CAM Acrylic Resin: in Vitro Study
Authors: Mahmoud Ahmed Zakaria Ahmed , EL-Attar Mohamed Sherine , Abosaied Mohamed Abdel Rahim , Soliman Ingy Said 
Published: May 2022

Abstract
Background: The most common electronic nicotine delivery system is electronic cigarettes. Most electronic cigarettes consist of a battery, and an electric heater used to aerosolize a liquid to produce vapor that the user inhales. Smokers who have used electronic cigarettes to quit smoking, raising questions about the benefits and hazardous effects of using it. Polymethyl methacrylate contacts with a variety of foods and beverages of different temperatures, as a result, it is prone to absorbing a variety of pollutants, altering its physical structure and appearance. The aim of this study was to investigate the effects of electronic cigarette smoking on the color stability of acrylic resin.Material and methods: This study was in vitro study in which sixty specimens of CAD/CAM acrylic resin were exposed to aerosols that were flavored and non-flavored with nicotine content (0 mg, 6 mg, and 12 mg). A portable suction machine was modified to receive specimens and simulate smoking in vivo. Each specimen was exposed to 20 cycles of aerosol emitted by a single ECIG device using the smoking chamber. Each cycle consisted of 10 puffs with a puff duration of 4 seconds and an inter puff interval of 20 seconds totaling 3.6 minutes for each cycle. Color measurement was performed on the specimens before and after exposure to ECIG aerosol using a calibrated spectrophotometer.Results: Specimens exposed to flavorless 0 mg. nicotine aerosol showed the lowest delta E value 2.39 (±0.16) , while Specimens exposed to flavored 12 mg. nicotine showed the highest values 4.14 (±0.19). No significant difference in color change found between groups exposed to flavorless e-liquid, while a significant difference found between flavored 0 mg. nicotine and 12 mg. nicotine groups (P = 0.002).Also, a significant difference found between flavored 6 mg. nicotine and 12 mg. nicotine groups (P = 0.002). According to Two Way ANOVA, both flavor and nicotine contents have a significant effect on color change (P <0.0001).Conclusion: Exposure to flavored and non-flavored electronic cigarettes aerosol of different nicotine concentrations changed the color of acrylic resin. Both flavor and nicotine contents have a significant effect on color change.
Multi-Criteria Decision Making in Linguistic Values of Neutrosophic Trapezoidal Fuzzy Multi- numbers
Authors: Kannusamy Arun Prakash , M Suresh 
Published: May 2022

Abstract
Neutrosophic trapezoidal fuzzy multi-numbers (NTFMN) are a specific neutrosophic fuzzy multiset on a real number set that decision makers can use to represent their neutrosophic fuzzy multi-preference information. The occurrences in the NTFMN are several, with the potential of the same or memberships of truth, indeterminacy, and falsehood. Neutrosophic trapezoidal fuzzy multi-numbers(NTFMN) are a type of neutrosophic fuzzy numbers on a real number set that are used to anticipate the solution to multi-criteria decision-making situations. In this study, we begin by defining NTFMN and then develop a set of multiple-criteria decision-making issues with NTFMN alternatives. The expected value method is used to rank neutrosophic trapezoidal fuzzy multi-numbers and choose the best option. Finally, a numerical example is provided to demonstrate the method's practicality and efficiency.
Experiences and coping strategies of colostomy patients in Ghana: A Phenomenological study
Authors: Mensah Adwoa Bemah Boamah , Yeboah Vida , Amaniampong Er-Menan , Mensah Kofi Boamah , Kusi Grace , Apiribu Felix , Dzomeku Veronica Millicent , Attakorah Joseph 
Published: May 2022

Abstract
Background: Available empirical evidence shows increasing rates of stoma surgeries (i.e., colostomy) among persons in sub-Saharan Africa, particularly Ghana. Compared to developed countries, the management of colostomy is considered more stressful due to the absence of a homecare management model after discharge from the hospital. Yet, there exist a paucity of evidence on the experiences, challenges and coping strategies of persons living with colostomy after being discharged, within a resource constrained setting such as Ghana. Aims: The experiences and challenges as well as coping strategies of colostomy patients were explored and described in this study. Methods: Using a descriptive phenomenological design, semi-structured face-to-face interviews were conducted with a purposive sample of 15 patients with colostomy. Colaizzi’s analytical framework and a deductive process was employed to thematically analyse the data. Results: Themes that characterised participants’ experiences and challenges with colostomy comprised: social stigmatisation, social isolation/withdrawal, sex-related challenges, psychological experiences and challenges, suicidal ideation, physiological experiences and challenges, dietary/eating challenges, difficulties caring for colostomy, skin disorders, cost of colostomy accessories, and work restrictions. Amidst these experiences and challenges, participants were shown to promote their resilience in the face of adversity through assets and resources: social support, spirituality and religion, lifestyle modifications, nutritional and pharmacological strategies, and improvised stoma accessories.Conclusion: Persons living with colostomy experience numerous challenges that threatens their health and wellbeing. Yet, they rely on assets and resources to remain resilient in the face of these challenges. Findings have implications for policy interventions on public education, expansion of health insurance scheme, stoma nurse recruitment and training, and patients’ resilience healthcare strategies of colostomy in Ghana.
Mutation rates and adaptive variation among the clinically dominant clusters of Mycobacterium abscessus
Authors: Commins Nicoletta , Sullivan Mark , McGowen Kerry , Koch Evan , Rubin Eric , Farhat Maha 
Published: May 2022

Abstract
Mycobacterium abscessus (Mab) is a multi-drug resistant pathogen increasingly responsible for severe pulmonary infections. Analysis of whole genome sequences (WGS) of Mab demonstrates dense genetic clustering of clinical isolates collected from¬ disparate geographic locations. This has been interpreted as supporting patient-to-patient transmission, but epidemiological studies have contradicted this interpretation. Here we present evidence for a slowing of the Mab molecular clock rate coincident with the emergence of phylogenetic clusters. We find that clustered isolates are enriched in mutations affecting DNA repair machinery and have lower spontaneous mutation rates in vitro. We propose that Mab adaptation to the host environment through variation in DNA repair genes affects the organism’s mutation rate and that this manifests as phylogenetic clustering. These results inform our understanding of niche switching for facultative pathogens, and challenge the model of transmission as the major mode of dissemination of clinically dominant Mab clusters.
LINC01980 induced by TGF-beta promotes hepatocellular carcinoma metastasis via miR-376b-5p/E2F5 axis
Authors: Sheng Jiaqi , Lv Enjun , Liang Huifang , Tao Haisu , Yu Chengpeng , Rao Dean , Sun Mengyu , Xia Limin , Huang Wenjie 
Published: May 2022

Abstract
Hepatocellular carcinoma is one of the most aggressive human malignancies worldwide. However, the molecular mechanism of HCC metastasis is largely unknown. LncRNA has key roles in gene regulation, and dysregulation of lncRNA is critical to cancer metastasis. This study aims to explore the function and mechanism of LINC01980 in HCC metastasis and provides a new mechanism for transcription regulation of lncRNA. We first found that LINC01980 was upregulated and associated with poor prognosis in HCC. Besides, LINC01980 promoted HCC cells migration and invasion. Mechanistically, we proved that LINC01980 competitively bound miR-376b-5p to upregulate its target E2F5, thus inducing EMT in HCC cells. And, LINC01980-mediated HCC metastasis was dependent on E2F5 in vitro and vivo. In addition, our study showed that TGF-β activated LINC01980 transcription through the canonical TGF-β/SMAD signaling pathway in HCC. Overall, this study provided a new perspective to understand HCC metastasis and offered a new potential target for treating hepatocellular carcinoma.
Inborn Errors of Immunity in Children and Adolescents with Immune Thrombocytopenia
Authors: Beatrice Julia M. , Liphaus Bernadete L , Kamioka Priscila E. , Matsumoto Lucy C. , Correa-Silva Simone , Carneiro-Sampaio Magda M. S. , Carneiro Jorge D. A. 
Published: May 2022

Abstract
Immune thrombocytopenia (ITP) is a frequent autoimmune manifestation among Inborn Errors of Immunity (IEI). This study analyzed immunoglobulin and complement levels and lymphocyte subsets proportions in children and adolescents with primary ITP to reassess underlying IEI and establish relations with disease features and outcomes. Sixty ITP patients had IgA, IgM, IgG, IgE, C3, and C4 levels measured by standard methods used by the hospital. CD3+, CD4+, CD8 + and CD19 + lymphocyte proportions were determined by flow cytometry. Overall, 23.3% of the reassessed ITP patients could be considered to have underlying IEI namely, IgA deficiency (1/60), IgM deficiency (2/60), C4 deficiency (1/60), low B cells (3/60), low T cells (2/60) and unclassified IEI (4/60). In addition, as a whole, 86.7% of ITP patients had at least one altered immunoglobulin or complement level or lymphocyte subset proportion specifically, low IgG (23.3%), low IgM (8.3%), high IgG (1.7%), high IgM (11.7%), and high IgE (18.3%). Moreover, 6.7% of ITP patients had an additional autoimmune disease namely, type 1 diabetes and thyroiditis; 56.7% had an allergy diagnosis; 20.0% had a positive family history of autoimmune disease, and 70.0% had a family history of allergy. Patients with low IgM levels underwent significantly more splenectomy (87.5% vs. 25.0%, p = 0.04). In conclusion, underlying IEI could be diagnosed in children and adolescents previously presumed as primary ITP, reinforcing the idea that immunoglobulin and complement levels and lymphocyte subset proportions should periodically be reassessed during follow-up. Further genetic analyses will be a cornerstone for unveiling additional IEI related to ITP.
The antimicrobial effects of PLGA microspheres containing the antimicrobial peptide OP-145 on clinically isolated pathogens in bone infections
Authors: Cheng Ye , Qin Jianhua , Huang Yuliang , Wang Tianyu 
Published: May 2022

Abstract
Infection after fracture is a significant problem for the healing of fractures. Antimicrobial peptides combined with PLGA (poly-lactic-co-glycolic acid) microspheres can open new horizons for treating bone infections. Twenty rats in the control group were treated with physiologic saline solution after surgery, and 20 rats in the treatment group were treated with OP-145 PLGA microspheres and vancomycin after surgery. The biofilms from treatment and control groups were analyzed by fluorescence microscopy. Blood samples were collected at 12, 24, 36, 48, and 72 h. OP-145 PLGA microspheres showed significant inhibitory effects on clinically isolated strains (P < 0.05) and there were significant differences in serum CRP (P < 0.05) levels compared with control group. In conclusion, OP-145 PLGA microspheres could slowly release antimicrobial peptides and significantly reduce biofilm formation and levels of inflammatory factors.
Predicting fluid responsiveness using oesophagus Doppler monitoring and pulse oximetry; retrospective analysis of a prospective haemodynamic study
Authors: Hahn Robert G. , Nilsson Lena , Bahlmann Hans 
Published: May 2022

Abstract
Background.
Fluid therapy during major surgery can be managed by providing repeated bolus infusions until stroke volume no longer increases by ≥ 10%. However, the final bolus, also called an optimisation round, is not necessary, as it results in fluid overload. We studied how different cut-off values for the haemodynamic indications given by oesophagus Doppler monitoring, possibly augmented by pulse oximetry, are associated with a higher or smaller chance that stroke volume increases by ≥ 10% (fluid responsiveness) before the fluid is infused.
Methods.
An oesophagus Doppler and a pulse oximeter that displayed the Pleth Variability Index were used to monitor the effects of a bolus infusion in 110 patients undergoing goal-directed fluid therapy during major open abdominal surgery.
Results.
The overall incidence of fluid responsiveness was 44%, but this varied greatly depending on pre-infusion haemodynamics. The likelihood of being fluid-responsive was 30–38% in the presence of stroke volume > 80 mL, flow-corrected time > 360 ms, or Pleth Variability Index < 10%. The likelihood was 21% if stroke volume had decreased by < 8% since the previous optimisation, which decreased to 0% if combined with stroke volume > 100 mL. By contrast, the likelihood of fluid responsiveness increased to 50–55% when stroke volume ≤ 50 mL, flow-corrected time ≤ 360 ms, or Pleth Variability Index ≥ 10. A > 8% decrease in stroke volume since the previous optimisation was followed by a 58% likelihood of fluid responsiveness that, in combination any of the other mentioned haemodynamic variables, increased to 66–76%.
Conclusions.
Single or combined haemodynamic variables provided by oesophagus Doppler monitoring and pulse oximetry could help clinicians avoid unnecessary fluid bolus infusions.
Trial registration:
Clinical Trials (NCT01458678) registered on October 25, 2011, before any patient recruitment was initiated.
Transcriptomic profiling analysis of human endometrium treated with autologous platelet-rich plasma
Authors: Kuroda Keiji , Matsumoto Akemi , Horikawa Takashi , Takamizawa Satoru , Ochiai Asako , Kawamura Kazuhiro , Nakagawa Koji , Sugiyama Rikikazu 
Published: May 2022

Abstract
In in vitro fertilization treatment, the therapeutic effects of intrauterine platelet-rich plasma (PRP) infusion with increasing rate of successful pregnancy have been reported; however, the mechanisms that support embryo implantation remain unclear. To analyze transcriptomic profiles in endometria treated with PRP, blood and endometrial samples were collected from four infertile women. Human endometrial stromal cells (HESCs) were cultured and passaged equally into four cell culture dishes in each patient. Two were treated with PRP twice and the other two were not treated with PRP. Subsequently, two cultures with and without PRP were decidualized with 8-bromoadenosine 3',5'-cyclic AMP and progesterone for 5 days. The gene expression in undifferentiated or decidualized HESCs with and without PRP was compared. In the microarray analysis, 381 and 63 differentially expressed genes were detected in undifferentiated and decidualized HESCs, respectively. In the undifferentiated HESCs, PRP was found to strongly promote the gene expression associated with cell growth, tissue regeneration, proinflammatory response, and antibiotic effects. In decidualized HESCs, PRP was found to attenuate the gene expression involved in cell proliferation and inflammation by inhibiting the expression of PI3K signaling. PRP regulates the reprogramming of cell proliferation and inflammation depending on pre- and post-decidualization in an appropriate manner, suggesting that PRP has the potential to increase endometrial thickness in the proliferative phase and improve immune tolerance in the secretory phase.