bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network pharmacology-based strategy to investigate the molecular target and mechanism of Jiawei Linggui Zhugan decoction in the treatment of obesity
Authors: Wang Ning , Chen Hongda , Ye Zhiyu , Cao Nan , Mo Binyan , Qin Jian , Tan Li 
Published: June 2022

Abstract
Background. Jiawei Ling Gui Zhu Gan Decoction (JW-LZD) is based on LingguiZhugan Decoction (LZD) and adds eight traditional Chinese medicines: Codonopsispilosula, Astragalus membranaceus, Yam, Epimedium, Morinda officinalis, TangerinePeel, Pinellia ternata and Coix Seed, which can be used for the treatment of obesityin the clinical. In this study, we determined the molecular targets and mechanismsinvolved in obesity treatment through network pharmacological analysis, andmolecular docking technology. Material and Methods. Related compounds wereobtained from the TCMSP.Oral bioavailability and drug-likeness were screened usingpharmacokinetic criteria. Molecular targets were identified in the drug-bank databaseand compared with obesity disease differential genes with P < 0.05 and ∣ log2FC >0.5 obtained in the GEO-database to obtain cross genes and construct the TCMcompound disease regulation network. After constructing PPI, Go, and KEGGanalyses, the key active components and target genes were selected. Moleculardocking was carried out using AutoDock, and the best binding target was selected toselect the best binding target for molecular docking. Results. A total of 248 potentialcompounds and 30 strongly associated JW-LZD targets were identified. Pathwayenrichment analysis showed that putative JW-LZD targets mostly participated inadenylate cyclase-activating adrenergic receptor signaling, adrenergic receptorsignaling, regulation of signal receptor activity, coagulation, and other metabolicrelated biological processes. The molecular docking results showed that the key JWLZDcomponents have good potential to combine with the target genes ADRB2,ADRA2A, ADRA2C, CHEK1, CHEK2, and DGAT2. Conclusion. Our findingssuggest that JW-LZD prevent obesity through the molecular mechanisms predicted bynetwork pharmacology, providing a way to develop new combination medicines forobesity.
A Historical Example about which the Individual is Bartered Away to the Society: The Abuse of its Ancient Privileges, which were given to be Asserted by Fener Patrirchate
Authors: ATALAY Bülent 
Published: June 2022

Türkiye’de cemiyetin ve dolayısıyla ferdin, din istismarı yapılarak cemaate fedadan da öte kurban edildiği tarihî bir gerçektir. Bu gerçeği görmek için sadece süreçte meydana gelen olaylara bakmak yeterlidir. Söz konusu olan mesele, Osmanlı toplum yapısı bakımından sadece Müslümanları değil, aynı zamanda Gayrimüslimleri de yakından ilgilendirmektedir. Ferdî hürriyet, devlet toplum ilişkilerinin laikleşmesi ve demokratikleşmesi bağlamında çok önemlidir. Buna bağlı olarak toplumun tam olarak laikleşememesi ve gelişmiş bir demokratik anlayışa ulaşılamamasında sorumluluk sadece Müslümanlara değil, Gayrimüslimlere ve özellikle Rum Ortodokslara da aittir.
Hatta denilebilir ki Gayrimüslimlerin özellikle Ortodoks Rumların sorumluluğu daha fazladır. Çünkü Müslümanlar, içtihat kavramını tam anlamıyla kavrayamadıklarından çağı değerlendirmekte geri kaldılar. Ortodoks Rumlara gelince, nicelik ve nitelik olarak Gayrimüslim tebaa içerisinde diğerlerine göre daha önemliydiler. Buna bağlı olarak sorumlulukları da daha fazlaydı. Türkiye’de ferdî hak ve hürriyetlerin çağdaş düzeye çıkarılmaya başlanmasının miladı kabul edilebilecek Tanzimat ve sonrasındaki sürece muhalefet, Sünnî Müslüman din adamlarından ziyade, Gayrimüslim Ruhban ve özellikle Ortodoks Rum Ruhbandan gelmiştir.
Bunun da sebebi Ortodoks tebaanın bir mensubu olmaktan değil, Fener Patrikhanesi’ne mensup ruhban olmaktan kaynaklanmıştır. Ortodoks Ruhban, sahip oldukları üstünlüklerini kaybetme endişesiyle sürekli tepki göstermiştir. Türkiye’de ıslahatlar Avrupa Devletleri’nin açık telkin, tavsiyeleri ve örtülü tehditlerinin gölgesinde gerçekleştirilmeye çalışılmıştır. Aynı Avrupa Devletleri’nin desteğini arkasına alan Fener Patrikhanesi ve dolayısıyla Ortodoks Rum Ruhban sınıf, ıslahatlara karşı çıkmışlardır. Bununla da kalmayarak uygulanmaması için ellerinden geleni yapmışlardır. Rum Ruhban sınıf muhalif davranırken, tarihî bir “tahterevalli” ya da bir “manivela” şeklinde kullanarak var olduğunu iddia, fakat ispat edemediği kadim imtiyazlarını oldukça mahir bir şekilde istismar etmiştir. Çalışmamızda bu husus mümkün olduğu kadar, imkânlar dâhilinde izah edilmeye çalışılacaktır.
Many years of experience in the treatment of recurrent cervical cancer
Authors: Shumeikina A. , Samoylova E. , Vavilov K. , Krasilnikov S. , Pasman N. 
Published: June 2022

Background. The incidence of cervical cancer (CC) in the world is 500,000 new cases per year. In the structure of mortality from malignant neoplasms in women under 45 years of age, CC ranks 1st. Aim. To conduct a multivariate analysis of CC relapses, taking into account the results of primary treatment of CC patients for the subsequent choice of treatment methods for CC recurrences.Methods. Retrospective analysis of 105 case histories of patients for the period 2011–2021 who were treated at the Meshalkin National Medical Research Center and received therapy for recurrences of CC. Results. Stage I — 19 (18.1%), II — 32 (30.5%), III — 50 (47.6%), IV — 4 (3.8%). Primary methods of treatment: combined radiotherapy — 51 (49%), surgical method — 18 (17%), chemoradiotherapy — 18 (17%), surgery in combination with adjuvant radiotherapy — 15 (14%), polychemotherapy (with palliative purpose) — 1 (1%). In the structure of types of relapses: locoregional relapses — 42 (39%), local relapses — 31 (29%), metastatic hematogenous — 22 (20%), metastatic lymphogenous — 13 (12%). Late relapses (more than 12 months) — 65 (62%), early (6–12 months) — 22 (21%), progression (up to 6 months) — 18 (17%). Localizations for the occurrence of distant cervical cancer metastases: bones — 11 (39.3%), lungs — 10 (35.7%), brain — 3 (10.7%), liver — 4 (14.3%), lymphogenous metastases: supraclavicular lymph nodes — 5 (35.7%), inguinal lymph nodes — 8 (57.1%), abdominal lymph nodes — 1 (7.2%).Conclusion. In 62% there were late relapses, in 48% — in patients with initial stages, more frequent and longer follow-up with an oncogynecologist is indicated. Patients need treatment by an oncologist, radiologist, neurosurgeon, chemotherapist regardless of the stage, timing of occurrence, localization of relapses.
A Case of Fingolimod-associated Cryptococcal Meningitis
Authors: Darazam Ilad Alavi , Rabiei Mohammad Mahdi , Moradi Omid , Gharehbagh Farid Javandoust , Roozbeh Mehrdad , Nourinia Ramin , Hatami Firouze , Shojaei Maziar , Lotfollahi Legha 
Published: June 2022

Background:
Leukopenia, a rare adverse effect of Fingolimod therapy, paves the way
for opportunistic infections. In this study, we reported rare fingolimod associated cryptococcal
meningitis.

Case Presentation:
A 39-year-old woman with RRMS was referred to the emergency department.
The patient's major complaints were headache, fever, weakness, and progressive loss of consciousness
within the last two days prior to the referral. The patient had a history of hospitalization due to
RRMS [two times]. In the second hospitalization, interferon Beta-1a was replaced with Fingolimod.
Using polymerase chain reaction, Cryptococcus neoformans was detected in CSF. Liposomal
amphotericin B and fluconazole [800 mg per day] were started. Six weeks later, the patient was
discharged without any major complaints.

Conclusion:
Albeit fingolimod associated cryptococcal meningitis is a rare event, Fingolimod therapy
in patients with MS should be performed cautiously. Regular follow-ups may give rise to a
timely diagnosis of probable fingolimod associated cryptococcal meningitis. Fingolimod therapy
can lead to lymphocytopenia and various infections. We, therefore, suggest that intermittent blood
lymphocyte counts as well as monitoring of clinical manifestations among MS patients treated with
Fingolimod to avoid additional neurological and physical disabilities in these patients.
Diagnosis and Determination of Phosphine by Dynamic Headspace/ICP/AES in Biological Samples
Authors: Hassan Jalal , Karbasi Mohammad Hadi 
Published: June 2022

Objective:
Inductively coupled plasma atomic emission spectroscopy (ICP/AES) has been used
for the determination of phosphine residues in cereal and tissue biological samples.

Methods:
The method used is based on the reaction of phosphine residue with H2SO4 in a headspace vial,
determining the phosphor of the liberated phosphine gas by ICP/AES at 213.6 nm. At this wavelength,
there is a linear relationship between emission and concentration of phosphine in the range of 0.10 up to
0.50 μg g-1 (R2 = 0.990). The method is rapid and sensitive with the detection limit of 3.1 μg (S/N =3),
and the precision expressed as relative standard deviations (RSD %) is below 12% for 10 replicates.

Results:
The obtained results showed good agreement with the GC/NPD method.

Conclusion:
In this study, we develop a rapid analysis, inexpensive, easier handling, simple, repeatable,
and sensitive method for the determination of phosphine residue in various samples.
Measuring Mood and Anxiety Disorders by Patient Reported Outcomes in
Inflammatory Bowel Disease: A Literature Review Update
Authors: Spagnuolo Rocco , Basile Antonio , Corea Alessandro , Iaquinta Francesco Salvatore , Milić Nataša , Doldo Patrizia , Luzza Francesco , Abenavoli Ludovico 
Published: June 2022

Background:
Anxiety and depression are the most common psychological disorders
found in Inflammatory Bowel Disease (IBD) patients. Accurate measuring of these disorders should
be proposed for prompt management. Patient-reported outcome measurements (PROMs) allow
patients to self-report their psychological symptoms.

Objective:
The objective of this study is to highlight the presence of PROMs measuring anxiety and
depression in IBD setting, evaluating the most used psychometric tools.

Methods:
We reviewed the literature from 2010 up to September 2021. Articles on adult IBD
patients assessing depression and anxiety by PROMs in English language were included.

Results:
Thirty-six studies, including 11 psychometric tools were found. Hospital Anxiety and
Depression Scale (21 studies), Beck Depression Inventory II (5 studies), Spielberg State-Trait
Anxiety Inventory (3 studies), Patient-Reported Outcomes Measurement Information System (3
studies), Symptom Checklist-90 (2 studies), Euro Quality of Life (2 studies) mostly used
psychometric tools for anxiety and depression in IBD settings.

Conclusion:
Our review analyzed psychometric tools used for PROMs evaluating anxiety and
depression in IBD setting. No chronological differences have emerged, all have been used in the
last ten years, highlighting lack of specificity. The strong association between IBD and mood
disorders suggests that clinicians should consider the evaluation of depression and anxiety as
integral parts of IBD clinical care. It is essential to identify tools enabling these items to be detected
better. A global view of IBD patients, accounting not only for physical but also for psychical
symptoms with an early and feasible assessment of unrecognized psychiatric disorders, can have a
strong impact on their management strategy.
Neurotoxicity of Cisplatin as Monotherapy or Combined Chemotherapy in
Cancer Treatment
Authors: Volpini André Nunes , de Souza Marques Igor José , Cavalcanti Iago Dillion Lima 
Published: June 2022

Introduction:
The main toxicity of cisplatin is nephrotoxicity, but more and more studies
have highlighted and unveiled the mechanisms of cisplatin toxicity, and the neurotoxicity has been
standing out.

Objective:
We aimed to bring together the main studies that highlight the neurotoxicity of cisplatin in
the treatment of cancer patients.

Methods:
We performed a literature review using the keywords “Neurotoxicity”, “Cisplatin”, “Oncology Therapy”, and “Chemotherapy” in the SciELO, PubMed, Sciencedirect, MEDLINE, Scifinder,
and CAplus databases.

Results:
We selected 60 articles published between 1983 and 2021 that report the mechanisms of cisplatin toxicity or which provide clinical data on the neurotoxicity profile of cisplatin as monotherapy
and as a combination therapy, highlighting that one of the main neurotoxicity of cisplatin is in the
development of peripheral neuropathy.

Conclusion:
Cisplatin is neurotoxic and can induce the development of peripheral neuropathy and the
combination with neurotoxic drugs such as paclitaxel and vincristine only contributes to the increase
in neurological toxicity. Thus, we emphasize the importance of evaluating the neurotoxicity of cisplatin, especially in patients who use protocols that contain other antineoplastic agents that are also neurotoxic.
CHANGES OF THE STATE OF IMMUNITY AND HORMONAL SYSTEMS OF REGULATORY FOR THE SPORTSMEN OF HIGH CLASS ON DIFFERENT PERIODS TO THE TRAINING-COMPETITION ACTIVITY
Authors: Korzh V. P. 
Published: June 2022

The results of investigations represented at the article prove that the organism of an athlete reacts to physical overloads and due to this fact there is essentials increase of cortizol and serotonin levels. These changes are accompanied the expressed changes of immune status of organism of sportsmen. A change of parameters of immunity and hormonal systems of regulatory is the informing diagnostic criterion of the functional state of organism of sportsmen
INFLUENCE OF OOCYTIC MICROWAYS ON THE RESULT EXTRACORPORAL FERTILIZATION FOR HYPERANDROGENIA
Authors: Somova O. V. , Feskov O. M. , Feskova I. A. 
Published: June 2022

In 64 women with different androgenic status who were treated for infertilityin vitro fertilization methods, in the follicular fluid surrounding the oocytes, the levels of sex hormones, leptin, sex hormone-binding globulin, total antioxidant and total oxidative activity are determined. For excess androgens
An oxidative / antioxidant balance was observed in the follicular fluid in the direction of an increase in the total oxidative activity. In women with a day off
hyperandrogenism, the content of sex hormone-binding globulin and leptin in the oocyte microenvironment is essential for obtaining high-quality embryos and
achieving pregnancy in in vitro fertilization cycles.
ASSESSMENT OF THE PLATELET COMPONENT OF HEMOSTASIS IN RATS WITH METABOLIC SYNDROME AGAINST ESTROGEN DEFICIENCY
Authors: Gorbenko Nataliia , Oksenenko S. V. , Ivanova Olha , Borikov Oleksii , Stepanova A. V. , Taran K. V. , Zvyagina T. S. 
Published: June 2022

The platelet component of hemostasis in rats with metabolic syndrome induced by a high-fat diet under conditions of eu- and hypoestrogenism.
It was found that in females receiving a high-fat diet, there is an increase in the degree, and in ovariectomized rats kept on a standard
diet, the rate of ADP-induced platelet aggregation increases. The combined effect of diet and estrogen deficiency causes a more pronounced increase
of both studied indicators, which indicates the summation of their procoagulant effect.
THE ROLE OF SINGLE NUCLEOTIDE POLYMORPHISM +45T/G OF ADIPONEKTIN GENE (ADIPOQ) IN RISK OF TYPE II DIABETES MELLITUS DEVELOPMENT
Authors: Karachentsev Yuri , Gorshunska Maryana , Atramentova L. O. , Kravchun N. A. , Khizhnyak Oksana , Tyzhnenko T. V. , Grinchenko T. S. , Gladkih A. I. , Leshchenko Zhanna , Shevchenko Y. A. , Pochernyaev A. K. , Romanova I. P. , Poltorak V. V. 
Published: June 2022

Single nucleotide polymorphism (SNP) +45T/G gene of adiponectin (ADIPOQ) in type 2 diabetes mellitus patients and in healthy residents of Kharkiv has been taken into consideration. Frequencies of SNP +45T/G for patients (pG = 0,48; pT = 0,52) and healthy residents(pG = 0,49; pT = 0,51) do not differ significantly. The genotypes frequency in control group doesn’t correspond to HardyWeinberg equilibrium: the share of heterozygotes +45T/G is 1,8 times higher than selectively-neutral value. The type II diabetes mellitus patients have the share of heterozygotes +45T/G one third lower than in control group. The analysis has shown that heterozygotes genotype reduces the risk of type 2diabetes mellitus in seven times (p < 0,05) in comparison with a mean value in population.
THE CLINICAL AND HORMONAL CHARACTERISTICS OF PATHOLOGICAL PUBERTY IN RURAL RESIDENTS
Authors: Varodova O. V. 
Published: June 2022

For determining clinical and hormonal characteristics of sexual development disorders in boysfrom rural locality there were examined 62 adolescents aged 14–18 with clinical signs of sexual developmentdelay (SDD). The examination has shown that in one half of adolescents (51,6 %) sexualdevelopment is observed till the age of 3, in 43,8 % of patients sexual development degree is 3–4 years behind and only 4,7 % of youths (mainly at the age of 17–18) sexual development degree is 4 and even more years behind. The majority of adolescents with SDD (85,9 %) are likely to have deviations in their physical development with undersized stature as a prevailing feature. The pathological proportions of body have been revealed in all adolescents. Hormonal indexes of boys with SDD are characterized by a decreased level of one or both gonadotropins, an increased level of prolactin, a low testosterone level as well as disorders in T/ E2 correlation and by sensitivity of gonads to LH impact at the age of 14–15.
THE STATE OF COMPENSATION OF CARBOHYDRATE EXCHANGE AND HAEMODYNAMICS RATES OF THE LOWER EXTREMITIES IN CHILDREN OF DIFFERENT AGE WITH I TYPE DIABETES MELLITUS ON INPATIENT STAGE OF REHABILITATION TREATMENT
Authors: Kirilyuk M. L. , Volyanska V. S. , Govorova N. V. 
Published: June 2022

The article is dedicated to the study of the state of carbohydrate exchange compensation and haemodynamics rates of lower extremities in children of two age groups (6–13 and 14–17 years old) with type I diabetes mellitus after the inpatient treatment. It is found out that 14–17 years old children have a higher risk of getting complications of this disease according to the indicators of glycated hemoglobin. Complex treatment with the usage of magnitolazerotherapy, magnetic therapy and vortical baths directed to the lower extremities can improve the state of their haemodynamics in children of both age groups, especially in junior group.
THE INFLUENCE OF TETRAPEPTIDE PANCRAGENE® ON THE EXPERIMENTAL DIABETES MELLITUS DEVELOPMENT
Authors: Havinson V. H. , Malinin V. V. 
Published: June 2022

The analysis of amino acid sequences of insulinotropic polypeptides has revealed a common shortsegment, consisting of four amino acid residues. Tetrapeptide KEDWa analogous to this segment and protected from the effect of amino acid proteinases has been synthesized. The intramuscular administration of this tetrapeptide to rats with alloxan diabetes has promoted the insulin synthesis being partially restored. Under the condition of oral administration to rats with streptosotocin diabetes the tetrapeptide has exerted a pronounced hypoglycaemic effect within its administration. Intramuscular administration normalizes the adhesive ability of mesentery microvessels endothelium at the same time not affecting their permeability. The results point out a hypoglycaemic and endothelioprotective effect of the tetrapeptide in case of experimental diabetes mellitus.
THE DYNAMICS OF DAILY RHYTHMS OF THYROID GLAND HORMONAL ACTIVITY AT HYPOPINEALISM, INDUCED BY THE LONG-TERM AROUND-THECLOCK ILLUMINATION
Authors: Bondarenko L. O. , Sotnyk N. M. 
Published: June 2022

In sexually matured male rabbits kept in the conditions of around-the-clock illumination the daily dynamics of thyroxine concentration in the blood has been observed. The above-mentioned rhythm is not indicated in the case of triiodthyronine. In rabbits affected by hypopinealism and induced by a long-term around-the-clock illumination phase changes of thyroid gland hormonal activity are observed. These changes connected with the gradual decline of thyroid gland hormonal activity show up synchronously in the day time and at night.
Crises as impulses for changes in socio-economic systems
Authors: Mączyńska Elżbieta 
Published: June 2022

The analyses presented in this essay are aimed at identifying potential directions of rationalization of socio-economic systems, designed not only for counteracting crisis destructions, but most of all the current global crisisogenicity. The need to search for rationalising solutions is not only demonstrated by the crisis that is encompassing the world in connection with the COVID-19 pandemic and which exposes the systemic dysfunctions of the global economy. This is also confirmed by the crisis multiplication characteristic of the modern world and already occurring before the pandemic, i.e. the overlapping of various crises, which creates a specific thickening crisis network. This intensifies discussions and questions concerning possible future directions of change in socio-economic systems. These questions are even more important because of the persisting neoliberal so-called zombi-ideas, i.e. ideas which, despite the fact that reality absolutely does not confirm their validity, are artificially and in the interest of narrow social groups kept alive and constitute a barrier to restoring order in the local and global dimension. In this context, this essay analyzes concepts that differ from the neoliberal ones, including the concept of Doughnut economics by British economist Kate Raworth. This economist demonstrates that the more economic growth is not in harmony with social and ecological progress, the larger the hole inside the doughnut is. The centre hole of the model is a metaphor for social destruction and neglect. However, the field of the doughnut itself is a metaphor for a safe and just socio-economic model, eliminating poverty on the one hand and planet-destroying consumerist excess on the other. The inner bottom edge of the doughnut illustrates the goals of social justice and welfare, which should be expanded reducing aforesaid hole. The outer edge determines the impassable limits of the burdens on the natural environment. The relationship between this concept and the ordoliberal model of the social market economy is analyzed. By definition, it is a model of political system focused on socio-economic order, a model with a treaty and constitutional status in the European Union countries. Ordo means order. However, the formal enshrinement of this model does not fully translate into socio-economic reality. Therefore, this model needs to be strengthened and adapted to the requirements of the fourth industrial revolution encompassing the world nowadays. The analyses presented in this essay indicate that this reinforcement could be achieved through combining the intellectual potential of the SOME model and the Doughnut economic model. Both of these concepts have in common their pro-social orientation, harmonizing economic, social and environmental objectives, balancing the socio-economic system, which prevents the occurrence of asymmetries that are harmful to socio-economic development.