bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular occurrence and risk factors for Toxoplasma gondii infection in equids in Jilin, China
Authors: Liang Wanfeng , Zhao Shaowei , Wang Nan , Tang Zeyu , Zhao Fanglin , Liu Meng , Jin Weidong , Meng Yinbiao , Jia Lijun 
Published: July 2022

AbstractToxoplasma gondii, one of the important zoonotic parasites, has been detected in lots of hosts including humans, with a widespread prevalence. The products of equids, such as meat and milk, have been closely related to humans’ life. As the intermediate hosts, little is known about equids toxoplasmosis in Jilin province. Therefore, the present study aimed to evaluate the occurrence and risk factors of Toxoplasma gondii infections in equids from Jilin, northeastern China. In this study, a total of 245 blood samples of equids (192 horses, 25 donkeys and 28 mules) were collected from six localities in Jilin Province from March 2018 to August 2020 and detected by PCR. The occurrence rate of T. gondii B1 gene was analyzed using multivariable logistic regression to evaluate risk factors associated with the positive rates in equids. Among 245equids, T. gondii molecular occurrence was 9.0% (22/245). The highest positive rate was observed in equids from Dongfeng (16.3%) followed by Taonan (10.0%), Wangqing (8.3%), Antu (8.0%), Tonghua (8.0%) and Shulan (2.3%). Statistical analysis revealed that farming model and region may be two main risk factors. Data analysis indicated that the positive rate in captive farm (3.2%, 95% CI: 0.0–6.7%) was significantly lower than those in cage-free farm (P < 0.05), and the region of Shulan was protective factor (OR: 0.063, 95% CI: 0.007–0.559).The results of our study alert people to be aware that the present of equids T. gondii infection in this region, and contribute to a prevention and treatment program for toxoplasmosis in Jilin, China.
Modeling study of divertor particle and heat flux asymmetries for EAST H-mode discharges
Authors: Deng G. Z. , Lin X. D. 
Published: July 2022

AbstractThe BOUT++ transport code is run to study the effects of plasma drifts on the divertor out-in asymmetries (DOIAs) of particle and heat fluxes and their decay widths for EAST lower single null H-mode discharges. The diamagnetic drift seems to have no effects on the DOIAs of total particle and heat fluxes due to its divergence-free nature. However, it could significantly increase the DOIAs of peak particle and heat fluxes and the flux decay widths. The E × B drift is found to induce a large plasma flow to the divertor region, enhancing the DOIAs of both total and peak particle and heat fluxes and the flux decay widths. Both the radial and poloidal components of the E × B drift are necessary in increasing the DOIAs, however, the radial E × B drift seems to play a more important role. The effects on the DOIAs caused by both diamagnetic and E × B drifts are reversed with the reverse of toroidal magnetic field. The heat flux decay width λq and spreading width Sq are important physical and engineering parameters for the divertors and could be obtained by fitting the heat flux profiles at divertor targets. The λq at the outer target from the simulation case with all drifts could well match with the multi-machine scaling proposed by Eich and the DOIA of λq is in reasonable agreement with the scaling proposed by Goldston.
Evaluating the utility of an immune checkpoint-related lncRNA signature for identifying the prognosis and immunotherapy response of lung adenocarcinoma
Authors: Zhang Hongpan , Liu Meihan , Yang Zhihao , Du Guobo , Yu Bin , Gui Yan , Cao Lu , Li Xianfu , Tan Bangxian 
Published: July 2022

AbstractLung adenocarcinoma (LUAD) is the most frequent subtype of lung cancer globally. However, the survival rate of lung adenocarcinoma patients remains low. Immune checkpoints and long noncoding RNAs are emerging as vital tools for predicting the immunotherapeutic response and outcomes of patients with lung adenocarcinoma. It is critical to identify lncRNAs associated with immune checkpoints in lung adenocarcinoma patients. In this study, immune checkpoint-related lncRNAs (IClncRNAs) were analysed and identified by coexpression. Based on the immune checkpoint-related lncRNAs, we divided patients with lung adenocarcinoma into two clusters and constructed a risk model. Kaplan–Meier analysis, Gene Set Enrichment Analysis, and nomogram analysis of the 2 clusters and the risk model were performed. Finally, the potential immunotherapeutic prediction value of this model was discussed. The risk model consisting of 6 immune checkpoint-related lncRNAs was an independent predictor of survival. Through regrouping the patients with this model, we can distinguish between them more effectively in terms of their immunotherapeutic response, tumour microenvironment, and chemotherapy response. This risk model based on immune checkpoint-based lncRNAs may have an excellent clinical value for predicting the immunotherapeutic response and outcomes of patients with LUAD.
EMD-based data augmentation method applied to handwriting data for the diagnosis of Essential Tremor using LSTM networks
Authors: Otero José Fernando Adrán , López-de-Ipina Karmele , Caballer Oscar Solans , Marti-Puig Pere , Sánchez-Méndez José Ignacio , Iradi Jon , Bergareche Alberto , Solé-Casals Jordi 
Published: July 2022

AbstractThe increasing capacity of today’s technology represents great advances in diagnosing diseases using standard procedures supported by computer science. Deep learning techniques are able to extract the characteristics of temporal signals to study their patterns and diagnose diseases such as essential tremor. However, these techniques require a large amount of data to train the neural network and achieve good results, and the more data the network has, the more accurate the final model implemented. In this work we propose the use of a data augmentation technique to improve the accuracy of a Long short-term memory system in the diagnosis of essential tremor. For this purpose, the multivariate Empirical Mode Decomposition method will be used to decompose the original temporal signals collected from control subjects and patients with essential tremor. The time series obtained from the decomposition, covering different frequency ranges, will be randomly shuffled and combined to generate new artificial samples for each group. Then, both the generated artificial samples and part of the real samples will be used to train the LSTM network, and the remaining original samples will be used to test the model. The experimental results demonstrate the capability of the proposed method, which is compared to a set of 10 different data augmentation methods, and in all cases outperforms all other methods. In the best case, the proposed method increases the accuracy of the classifier from 83.20% to almost 93% when artificial samples are generated, which is a promising result when only small databases are available.
Pharmacological sequestration of mitochondrial calcium uptake protects against dementia and β-amyloid neurotoxicity
Authors: Shevtsova Elena F. , Angelova Plamena R. , Stelmashchuk Olga A. , Esteras Noemi , Vasil’eva Nataliia A. , Maltsev Andrey V. , Shevtsov Pavel N. , Shaposhnikov Alexander V. , Fisenko Vladimir P. , Bachurin Sergey O. , Abramov Andrey Y. 
Published: July 2022

AbstractAll forms of dementia including Alzheimer’s disease are currently incurable. Mitochondrial dysfunction and calcium alterations are shown to be involved in the mechanism of neurodegeneration in Alzheimer’s disease. Previously we have described the ability of compound Tg-2112x to protect neurons via sequestration of mitochondrial calcium uptake and we suggest that it can also be protective against neurodegeneration and development of dementia. Using primary co-culture neurons and astrocytes we studied the effect of Tg-2112x and its derivative Tg-2113x on β-amyloid-induced changes in calcium signal, mitochondrial membrane potential, mitochondrial calcium, and cell death. We have found that both compounds had no effect on β-amyloid or acetylcholine-induced calcium changes in the cytosol although Tg2113x, but not Tg2112x reduced glutamate-induced calcium signal. Both compounds were able to reduce mitochondrial calcium uptake and protected cells against β-amyloid-induced mitochondrial depolarization and cell death. Behavioral effects of Tg-2113x on learning and memory in fear conditioning were also studied in 3 mouse models of neurodegeneration: aged (16-month-old) C57Bl/6j mice, scopolamine-induced amnesia (3-month-old mice), and 9-month-old 5xFAD mice. It was found that Tg-2113x prevented age-, scopolamine- and cerebral amyloidosis-induced decrease in fear conditioning. In addition, Tg-2113x restored fear extinction of aged mice. Thus, reduction of the mitochondrial calcium uptake protects neurons and astrocytes against β-amyloid-induced cell death and contributes to protection against dementia of different ethology. These compounds could be used as background for the developing of a novel generation of disease-modifying neuroprotective agents.
A study in University of Ruhuna for investigating prevalence, risk factors and remedies for psychiatric illnesses among students
Authors: Wijesekara Patikiri Arachchige Don Shehan Nilm 
Published: July 2022

AbstractThere is no comprehensive study on the mental health of Sri Lankan undergraduate in higher education, as most existing studies have been done for medical students only. It is unknown how academic and environmental factors contribute for the prevalence of psychiatric illnesses. Further, there is no sufficient information on the student/university based remedies to reduce the psychological distress of students. This research is carried out to find the overall psychological distress, well-being, prevalence percentages of psychiatric illnesses, associated risk factors, and student/university remedies to overcome them. We use standard questionnaires to screen for psychiatric illnesses, and we analyze the responses for our own questionnaire using Binary logistic regression analysis to identify demographic factors, academic factors, and environmental factors causing each mental disorder. We use Pearson correlation coefficient to identify correlation between prevalence of each psychiatric illnesses. All 13 psychiatric illnesses were found with a moderate correlation among diseases having a mean prevalence percentage of 28 and a standard deviation of 14.36, despite the prevalence of well-being factors among students and only 8% are clinically diagnosed. 89% of the students were suffering from at least one psychiatric illness and 68% were found to be psychologically distressed. Sets of overall and individual demographic, academic, and environmental risk factors contributing for the prevalence of a psychiatric illness in general and in particular were identified respectively after a binary logistic regression analysis. 61% of the students don’t receive psychiatric help from the university and are using their own remedies. The universities must consider the environmental and academic risk factors associated with psychiatric illnesses and design curriculum, expand resources, and provide counseling services to reduce the impact of risk factors.
Wind tunnel experimental calibration of hemispherical 7-hole probe pressure–velocity parametric equation
Authors: Yao Tao , Zhou Shu-dao , Ye Song , Zhang Yang-chun 
Published: July 2022

AbstractThe multi-hole probe can measure the velocity and three-dimensional direction of the flow field at the same time, so it is often used to measure the three-dimensional flow field. Compared with other flow field measuring instruments, the multi-hole probe has stronger environmental adaptability and stability, and can better measure the three-dimensional flow field of the middle atmosphere. Therefore, a hemispherical 7-hole probe was designed, a pressure–velocity parameterized equation was established based on the theory of flow around a sphere, and a new calibration method was developed based on this. The calibration is carried out in a subsonic low speed wind tunnel, multiple combinations of flow parameters (inflow velocity and flow angles) are adjusted during the calibration. The results are compared with the numerical simulation results, both are quite close, with a speed measurement deviation of less than 5% and an angle measurement deviation of less than 1°. Our results establish the practicality of the hemispherical 7-hole probe and the simplified calibration procedure, both of which improve calibration efficiency and lower probe calibration costs.
Fabrication of polyamide-12/cement nanocomposite and its testing for different dyes removal from aqueous solution: characterization, adsorption, and regeneration studies
Authors: Aldahash Saleh Ahmed , Higgins Prerna , Siddiqui Shaziya , Uddin Mohammad Kashif 
Published: July 2022

AbstractPolyamide-12/Portland cement nanocomposite was prepared by using the exfoliated adsorption method. The fabricated nanocomposite was applied first time to remove Congo red (CR), brilliant green (BG), methylene blue (MB), and methyl red (MR) from the synthetic wastewater. The polymer nanocomposite was characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, elemental mapping, Brunauer–Emmett–Teller surface area analysis, and X-ray diffraction. The adsorption was rapid and all the studied dyes were absorbed on the surface of the polymer nanocomposite in 90 min. The point of zero charge was found at pH 5 and the factors such as pH, time, and temperature were found to affect the adsorption efficiency. Freundlich isotherm and pseudo-second-order models well-fitted the adsorption isotherm and kinetics data, respectively. The calculated maximum adsorption capacity was 161.63, 148.54, 200.40, and 146.41 mg/g for CR, BG, MB, and MR, respectively. The mode of the adsorption process was endothermic, spontaneous, and physical involving electrostatic attraction. On an industrial scale, the high percentage of desorption and slow decrease in the percentage of adsorption after every five regeneration cycles confirm the potential, practicality, and durability of the nanocomposite as a promising and advanced adsorbent for decolorization of colored wastewater.
Probability matching is not the default decision making strategy in human and non-human primates
Authors: Saldana Carmen , Claidière Nicolas , Fagot Joël , Smith Kenny 
Published: July 2022

AbstractProbability matching has long been taken as a prime example of irrational behaviour in human decision making; however, its nature and uniqueness in the animal world is still much debated. In this paper we report a set of four preregistered experiments testing adult humans and Guinea baboons on matched probability learning tasks, manipulating task complexity (binary or ternary prediction tasks) and reinforcement procedures (with and without corrective feedback). Our findings suggest that probability matching behaviour within primate species is restricted to humans and the simplest possible binary prediction tasks; utility-maximising is seen in more complex tasks for humans as pattern-search becomes more effortful, and we observe it across the board in baboons, altogether suggesting that it is a cognitively less demanding strategy. These results provide further evidence that neither human nor non-human primates default to probability matching; however, unlike other primates, adult humans probability match when the cost of pattern search is low.
Speckle-based high-resolution multimodal soft sensing
Authors: Shimadera Sho , Kitagawa Kei , Sagehashi Koyo , Miyajima Yoji , Niiyama Tomoaki , Sunada Satoshi 
Published: July 2022

AbstractSkin-like soft sensors are key components for human–machine interfaces; however, the simultaneous sensing of several types of stimuli remains challenging because large-scale sensor integration is required with numerous wire connections. We propose an optical high-resolution multimodal sensing approach, which does not require integrating multiple sensors. This approach is based on the combination of an optical scattering phenomenon, which can encode the information of various stimuli as a speckle pattern, and a decoding technique using deep learning. We demonstrate the simultaneous sensing of three different physical quantities—contact force, contact location, and temperature—with a single soft material. Another unique capability of the proposed approach is spatially continuous sensing with an ultrahigh resolution of few tens of micrometers, in contrast to previous multimodal sensing approaches. Furthermore, a haptic soft device is presented for a human–machine interface. Our approach encourages the development of high-performance smart skin-like sensors.
Increasing vitamin C through agronomic biofortification of arugula microgreens
Authors: Kathi Shivani , Laza Haydee , Singh Sukhbir , Thompson Leslie , Li Wei , Simpson Catherine 
Published: July 2022

AbstractVitamin C (Vit C) is an essential micronutrient and antioxidant for human health. Unfortunately, Vit C cannot be produced in humans and is ingested through diet while severe deficiencies can lead to scurvy. However, consumption is often inconsistent, and foods vary in Vit C concentrations. Biofortification, the practice of increasing micronutrient or mineral concentrations, can improve the nutritional quality of crops and allow for more consistent dietary levels of these nutrients. Of the three leading biofortification practices (i.e., conventional, transgenic, and agronomical), the least explored approach to increase Vit C in microgreens is agronomically, especially through the supplemental application of ascorbic acid. In this study, biofortification of Vit C in microgreens through supplemental ascorbic acid was attempted and proven achievable. Arugula (Eruca sativa 'Astro') microgreens were irrigated with four concentrations of ascorbic acid and a control. Total Vit C (T-AsA) and ascorbic acid increased in microgreens as supplementary concentrations increased. In conclusion, biofortification of Vit C in microgreens through supplemental ascorbic acid is achievable, and consumption of these bio-fortified microgreens could help fulfill the daily Vit C requirements for humans, thereby reducing the need for supplemental vitamins.
c-di-AMP signaling plays important role in determining antibiotic tolerance phenotypes of Mycobacterium smegmatis
Authors: Pal Aditya Kumar , Ghosh Anirban 
Published: July 2022

AbstractIn this study, we probe the role of secondary messenger c-di-AMP in drug tolerance, which includes both persister and resistant mutant characterization of Mycobacterium smegmatis. Specifically, with the use of c-di-AMP null and overproducing mutants, we showed how c-di-AMP plays a significant role in resistance mutagenesis against antibiotics with different mechanisms of action. We elucidated the specific molecular mechanism linking the elevated intracellular c-di-AMP level and high mutant generation and highlighted the significance of non-homology-based DNA repair. Further investigation enabled us to identify the unique mutational landscape of target and non-target mutation categories linked to intracellular c-di-AMP levels. Overall fitness cost of unique target mutations was estimated in different strain backgrounds, and then we showed the critical role of c-di-AMP in driving epistatic interactions between resistance genes, resulting in the evolution of multi-drug tolerance. Finally, we identified the role of c-di-AMP in persister cells regrowth and mutant enrichment upon cessation of antibiotic treatment.
High-speed and high-contrast two-channel all-optical modulator based on solution-processed CdSe/ZnS quantum dots
Authors: Dortaj Hannaneh , Faraji Mohammad , Matloub Samiye 
Published: July 2022

AbstractRecently, all-optical modulators are potentially the most promising candidate to achieve high-bit rate modulation in high-speed all-optical communication technologies and signal processing. In this study, a two-channel all-optical modulator based on a solution-processed quantum dot structure is introduced for two sizes of quantum dots to operate at two wavelengths of MIR spectra (3 µm and 5 µm). To perform numerical and theoretical analysis and evaluate the optical behavior of the proposed all-optical modulator, the coupled rate and propagation equations have been solved by considering homogeneous and inhomogeneous broadening effects. The modulation depth at the 50 GHz frequency and 3 mW probe power is attained, about 94% for channel-1 with the wavelength of 559 nm at 300 Wcm−2 pump power density as well as approximately 83.5% for channel-2 with the wavelength of 619 nm at 500 Wcm−2 pump power density. The introduced two-channel all-optical modulator can operate simultaneously at two wavelengths during the modulation process in which information could be transmitted through both signals from the control light. This approach can present the practical device as a high-contrast and high-speed two-channel all-optical modulator with a high modulation depth in numerous applications such as thermal imaging in night vision cameras, wavelength de-multiplexing, signal processing, free-space communication.
Virtual reality and its use in post-operative pain following laparoscopy: a feasibility study
Authors: Payne Olivia , Smith Vinayak , Rolnik Daniel L. , Davies-Tuck Miranda , Warty Ritesh , Seo Densearn , Wetherell Lima , Murday Hamsaveni Kalina , Nair Amrish , Kaur Rashvinder , Vollenhoven Beverley 
Published: July 2022

AbstractPain following laparoscopic surgery remains a neglected healthcare issue. Virtual reality-mediated therapy’s (VRT) analgesic potential could address this. However, its effect in this setting remains unexplored. We aimed to establish the feasibility and safety of VRT as an adjunct analgesic following gynaecological laparoscopy and explore differences between active distraction and passive meditation content. 35 women were enrolled into an open crossover pilot and randomised to either intervention group 1 (active then passive content) or intervention group 2 (passive then active content) following surgery. VRT was administered in two 10-min segments with a 10-min washout period in between. Pain scores, opioid requirements and side effects were recorded before and after each segment whilst questionnaires evaluated acceptability. We observed a significant reduction in pain over time for the entire study population (F = 8.63, p < 0.0005) but no differences between intervention groups, in contrast to many studies demonstrating an increase in pain during this time. During segment one, intervention group 1 (n = 18) were administered significantly less opioid than intervention group 2 (n = 17) [0.0 (0.0–7.5) vs. 3.0(0.0–10.0), p = 0.04]. Intervention group 1 rated the VRT experience significantly higher than intervention group 2 (7.97 vs. 6.62. p = 0.017). 97.1% (n = 34) would recommend VRT to a friend and use it as the standard-of-care in future procedures. These results demonstrate that post-operative VRT is feasible and safe. However, adequately powered studies are needed to appropriately determine its efficacy.