bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Summary of the Current Efforts of the Orthopaedic Trauma Association Task Force for Patient Mental Health Care
Authors: Wolinsky Philip , Ring David , Vallier Heather 
Published: September 2022

Summary:
Caring for patients' mental health and their physical health is critical during recovery after trauma. The Orthopaedic Trauma Association has created a patient mental health task force to address the mental health care aspect of our patients' care. This article summarizes the task forces goals and activities to date.
Patient Mental Health and Well-being: Its Impact on Orthopaedic Trauma Outcomes
Authors: Stinner Daniel J. , Mir Hassan R. 
Published: September 2022

Summary:
A patient's mental health can have a significant impact on their orthopaedic trauma outcome. It is important for orthopaedic surgeons to identify patients at risk for a poor outcome based on their mental health, to include the presence of post-traumatic stress disorder, depression, and anxiety, among others. Although some behaviors such as catastrophizing have been associated with worse outcomes, others, such as possessing greater self-efficacy have been associated with improved outcomes. Because of the high prevalence of mental health conditions that can have a detrimental effect on outcome, screening should be routinely conducted and at-risk patients referred to appropriate resources in an effort to optimize outcomes.
Combat Trauma-Related Acute Respiratory Distress Syndrome: A Scoping Review
Authors: Broderick Joseph C , Mancha Fabiola , Long Brit J. , Maddry Joseph K. , Chung Kevin K. , Schauer Steven G. 
Published: September 2022

OBJECTIVE:
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are known complications of injuries in combat casualties, but there has been no review characterizing them. This scoping review aims to map the combat trauma-related ALI/ARDS literature and characterize these conditions in the military population.

DATA SOURCES:
Pubmed was searched from 1969 to April 2022.

STUDY SELECTION:
Studies were included if they examined ALI/ARDS or related entities (blast lung injury [BLI], transfusion-related acute lung injury, and acute respiratory failure) in combat trauma patients in the military (U.S. or allied forces).

DATA EXTRACTION:
Study years, design, location, number of patients, target outcomes as related to ALI/ARDS or related entities, and results were collected.

DATA SYNTHESIS:
The initial search yielded 442 studies, with 22 ultimately included. Literature on ALI/ARDS comes mostly from retrospective data and case studies, with limited prospective studies. The incidence and prevalence of ALI/ARDS range from 3% to 33%, and mortality 12.8% to 33%. BLI, a known antecedent to ALI/ARDS, has an incidence and mortality ranging from 1.4% to 40% and 11% to 56%, respectively. Risk factors for ALI/ARDS include pulmonary injury, inhalation injury, blunt trauma, pneumonia, higher military injury severity score, higher injury severity score, higher fresh frozen plasma volumes, higher plasma and platelet volumes, the use of warm fresh whole blood, female sex, low blood pressure, and tachycardia. Literature has demonstrated the effectiveness in transportation of these patients and the utility of extracorporeal life support.

CONCLUSIONS:
ALI/ARDS incidences and prevalences in modern conflict range from 3% to 33%, with mortality ranging from 12.8% to 33%. ALI/ARDS has been associated with injury severity metrics, injury type, resuscitative fluid amount and type, vital signs, and patient demographics. Studies are limited to mostly retrospective data, and more data are needed to better characterize these conditions.
Is reducing the early postoperative complications of percutaneous suprapubic catheterization affected by the method of healthcare education in low-literacy patients? A prospective randomized comparative study
Authors: Gadelkareem Rabea Ahmed , Abozead Shalabia Elsayed , Khalaf Rasha Abozead , Mohammed Nasreldin , Khalil Shaymaa Sayed 
Published: September 2022

Abstract

Background
Suprapubic catheters (SPCs) are associated with a wide spectrum of undesirable symptoms and complications, ranging from skin overgranulation to septicemia. They can be effectively managed through various medical and healthcare interventions. We compared the impact of illustrated brochure healthcare education (IBHE) and verbal-only healthcare education (VOHE) on early postoperative complications of SPC in patients with low literacy levels.

Materials and methods
Eighty patients with low literacy levels who underwent SPC insertion were randomly allocated to receive either IBHE or VOHE between January 2019 and June 2020. Variables, including postoperative complications (within 30 days), were compared. This study was approved by our institutional review board (IRB number: 1780011/2019).

Results
The IBHE and VOHE groups included 40 patients each. The mean age ± standard deviation was 52.75 ± 16.46 and 53.25 ± 17.19 years, respectively. Acute urinary retention was the main presenting symptom (36 [90%] vs. 34 [85%]), and benign prostatic hyperplasia was the main underlying pathology (16 [40%] vs. 15 [37.5%]). The incidence of SPC obstruction (p = 0.000), urine leakage (p = 0.006), falling out (p = 0.003), suprapubic pain (p = 0.012), exit skin manifestations (p = 0.000), bleeding (p = 0.041), change (p = 0.003), and hematuria (p = 0.000) was significantly lower in IBHE than in VOHE. However, catheter-associated bladder discomfort (p = 0.247), bacteriuria (p = 0.154), and gross pyuria (p = 0.625) were not significantly different between the groups. The frequency of Clavien-Dindo grades was significantly higher in the VOHE group than in the IBHE group. Grade I (87.5% vs. 67.5%, p = 0.032) and grade IIIa (2.5% vs. 22.5%, p = 0.007) were significantly more frequent in the highest grade in IBHE and VOHE groups, respectively.

Conclusions
IBHE appears to be a suitable and effective method for educating low-literacy patients undergoing SPC insertion. It significantly reduced the incidence and grade of early postoperative SPC complications compared with VOHE, except for catheter-associated bladder discomfort, bacteriuria, and gross pyuria.
Cowden Disease: A Review
Authors: Magaña Mario , Landeta-Sa Ana P. , López-Flores Yessica 
Published: September 2022

Abstract:
PTEN hamartoma tumor syndrome (PTHS) includes diseases with germline pathogenic variants in the PTEN gene. Cowden syndrome is included in this syndrome. PTEN (phosphatase and tensin homolog) is a tumor suppressor gene located on chromosome 10q22-23; nearly 60%–90% of pathogenic variants are inherited. Cowden syndrome is a rare autosomic dominant condition, affecting approximately 1/200,000 people worldwide. Patients present benign and, malignant neoplasms in multiple organs, mostly breast and thyroid. The skin is the organ affected most consistently by Cowden disease. It is an autosomal dominant condition, characterized clinically by the presence of innumerable verrucous lesions on the skin. Interpretations of histopathologic findings in the cutaneous and mucosal lesions continue to be a matter of debate.
Unique Variation of Barber’s Disease: A Case Report
Authors: Grady Edmund Michael , Ozyurekoglu Tuna 
Published: September 2022

Summary:
Barber’s disease is an occupational-related disease in which small hair fragments penetrate the dermis of the hand. Although there is limited literature related to the topic, barber’s disease classically involves the interdigital space of hairdressers’ hands. In this case report, we report an undescribed variation of the condition. The case involves a female hair stylist who presented to the office with numerous hair splinters under the nail plate of her dominant thumb. Subsequent evaluation revealed cystic destruction of the distal phalanx of the thumb. Despite preoperative suspicion for osteomyelitis, pathology revealed reactive bone fragments associated with surrounding tenosynovial tissue and no evidence of osteomyelitis. The proposed etiology of this finding is the inflammatory process related to a hair abscess that formed with a sinus originating in the lateral nail fold. The goal of the case report is to bring to light yet another variation of barber’s disease.
Intraspinal choristoma in the lumbar region: A case report
Authors: Yang Jinxin , Liang Qianlei , Wang Yan , Han Liang , Guo Yongchuan 
Published: September 2022

Rationale:
Intraspinal choristoma is a relatively uncommon intervertebral canal tumor. Prior to our reports, only 2 cases of intraspinal choristoma had been reported. Because this disease is not common and looks like a mass of fatty tissue on the magnetic resonance imaging (MRI), intraspinal choristoma can be easily misdiagnosed as teratomas or lipomas (like the case of this article presenting) without a pathology report. So if a lumber intraspinal lesion is discovered in a clinical examination, intraspinal choristoma should be considered as a differential diagnosis. We present a case of intraspinal choristoma that is unlike any other reported case.

Patient concerns:
A 35-year-old woman with left lower extremity hypoesthesia and burning-like pain in the lumbar region for 1 month visited the local hospital for plain lumbar spine MRI. The patient was diagnosed with a lumbar space-occupying lesion. A second plain lumbar spine MRI scan and a MRI scan with enhancement were performed in our hospital to confirm the presence of a congenital lipoma in the spinal canal. A postoperative biopsy of the lumbar spinal mass indicated that the mass was an intraspinal choristoma located in the spinal canal.

Diagnosis:
Intraspinal choristoma.

Intervention:
The lesion was surgically removed, and follow-up plain and enhanced MRI images of the patient’s lumbar spine were obtained.

Outcomes:
After surgery, the patient no longer experienced the burning pain in her lumbar region or the left lower extremity hypoesthesia when the patient was discharged. And there was no evidence of recurrence 2 years after the surgery.

Lessons:
The MRI presentation of intraspinal choristoma is similar to intraspinal lipoma. Therefore, a pathological assessment is critical to provide an accurate diagnosis.
Clinical efficacy and safety of removing blood stasis and resolving phlegm in the treatment of epilepsy with cognitive impairment: A systematic review and meta-analysis
Authors: Yu Yang Yang , Yuan Can Xing , Gu Chao 
Published: September 2022

Backgrounds:
Epilepsy is a chronic encephalopathy caused by abnormal discharge of neurons in the brain, resulting in brain dysfunction. Cognitive impairment is one of the most common complications of epilepsy. The current treatment of epilepsy in the control of symptoms at the same time cause a lot of side effects, especially the aggravation of cognitive impairment. Many literatures have stated that the efficacy and safety of integrated Traditional Chinese and western medicine in the treatment of epilepsy with cognitive impairment is superior to that of western medicine alone. In this systematic review and meta-analysis, we intend to evaluate the clinical efficacy and safety of removing stasis and resolving phlegm in the treatment of epilepsy with cognitive impairment.

Objective:
To systematically evaluate the clinical efficacy and safety of removing blood stasis and resolving phlegm in the treatment of epilepsy with cognitive impairment.

Methods:
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed to conduct this systematic review. The Chinese Journal Full Text Database (CNKI), Wanfang Database, CQVIP Database (CQVIP), Cochrane Library, EMbase, and Pubmed were searched by computer, and randomized controlled studies on the efficacy of removing blood stasis and resolving phlegm in the treatment of epilepsy with cognitive disorders were included. Retrieval was carried out until January 2022, and relevant data were extracted for meta-analysis using Rev Man5.3 software.

Results:
Fourteen randomized controlled studies with a total of 1198 patients were included, including 601 patients in the control group and 597 patients in the treatment group (experimental group).

Results:
Meta-analysis results showed that compared with the treatment of epilepsy with cognitive impairment in the western anti-epileptic drugs group alone, the treatment of epilepsy with cognitive impairment combined with the method of removing blood stasis and resolving phlegm could significantly improve the clinical efficacy of epilepsy (OR = 3.41, 95% CI 2.39–4.88, P < .001). Improved the TCM symptom score (OR = 3.99, 95% CI 1.72–9.26, P < .001). Increased the EEG improvement rate (RR = 1.39, 95% CI 1.05–1.84, P = .02). Improved MOCA score and cognitive function (MD = 3.54, 95% CI 1.68–5.40, P < .001). Improved QOLIE-31 cognitive function score. Improved cognitive function (MD = 7.22, 95% CI 3.35–11.08, P < .001). Improved the incidence of adverse reactions (RR = 0.50, 95% CI 0.33–0.76, P = .001).

Conclusion:
Compared with the treatment of epilepsy with cognitive impairment by western anti-epileptic drugs alone, the treatment of epilepsy with cognitive impairment combined with the method of removing blood stasis and resolving phlegm is superior to the treatment of epilepsy with cognitive impairment by western anti-epileptic drugs alone.
Epidermoid cyst in ureter: A case report
Authors: Jing Qiang , Wang Xin , Yuan Xiaobin , Liu Fan , Zhang Xuhui 
Published: September 2022

Rationale:
Uro-originated epidermoid cysts, especially located in the upper urinary tract are rare and only 4 cases of epidermoid cyst occurring in the upper urinary tract have been reported worldwide so far. In the previous cases, the cysts were diagnosed as tumors and organs were removed.

Patient concerns and diagnosis:
We report a case of epidermoid cyst in ureter in a 48-year-old female patient admitted to the local hospital suffering from paroxysmal pain in the right hypochondriac for 8 years.

Interventions and outcomes:
She underwent right ureteroscopy in order to rule out the possibility of urinary epithelial carcinoma. The tumor was pathological diagnosed as a benign ureterocyst epidermoid. Postoperatively, the patient showed good recovery. During the 24-month follow-up period, the patient remained well and free of complications.

Conclusion:
This case illustrates that benign epidermoid cysts can appear in the ureter, although it is extremely rare. It also indicates that perioperative examinations must be exhaustive to avoid the further injury to the patients.
Efficacy of albumin with diuretics in mechanically ventilated patients with hypoalbuminemia: A systematic review and meta-analysis
Authors: Itagaki Yuki , Yoshida Naofumi , Banno Masahiro , Momosaki Ryo , Yamada Kohei , Hayakawa Mineji 
Published: September 2022

Background:
Hypoalbuminemia is associated with fluid overload, the development of acute respiratory distress syndrome, and mortality. The co-administration of albumin and diuretics for the treatment of patients with hypoalbuminemia is expected to increase urine output, without hemodynamic instability, and improve pulmonary function; however, these effects have not been systematically investigated. Here, we aimed to clarify the benefits of the co-administration of albumin and diuretics in mechanically ventilated patients.

Methods:
We searched for randomized, placebo-controlled trials that investigated the effects of the co-administration of albumin and diuretics compared with placebo and diuretics, in mechanically ventilated patients with hypoalbuminemia. We searched these trials in the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE via PubMed, and EMBASE databases. Primary outcomes were hypotensive events after the intervention, all-cause mortality, and the length of mechanical ventilation. Secondary outcomes were improvement in the ratio of partial pressure arterial oxygen and fraction of inspired oxygen (P/F ratio) at 24 hours, total urine output (mL/d), and the clinical requirement of renal replacement therapy (RRT).

Results:
From the 1574 records identified, we selected 3 studies for quantitative analysis. The results of albumin administration were as follows: hypotensive events (risk ratio [RR] 0.33 [95% CI: 0.15 -0.81]), all-cause mortality (RR 1.0 [95% CI: 0.45–2.23]), the length of mechanical ventilation in days (mean difference −0.34 [95% CI: −1.99 to 1.31]), and improvement in P/F ratio (RR 2.83 [95% CI: 1.42–5.67]). None of the randomized controlled trials reported the total urine output, and one reported that no participants required RRT. Adverse events were not reported during the trials. The certainty of evidence was low (in the hypotensive events after the intervention and all-cause mortality) to moderate (in the length of mechanical ventilation in days, improvement of P/F ratio, clinical requirement of RRT, and adverse events).

Conclusions:
Although this treatment combination reduced the number of days for which mechanical ventilation was required, it did not reduce the all-cause mortality at 30 days. In conclusion, the co-administration of albumin and diuretics may reduce hypotensive events and improve the P/F ratio at 24 hours.
Hub genes for early diagnosis and therapy of adamantinomatous craniopharyngioma
Authors: Zou Yang-Fan , Zhang Shu-Yuan , Li Li-Weng , Jing Kai , Xia Liang , Sun Cai-Xing , Wu Bin 
Published: September 2022

Background:
Adamantinomatous craniopharyngioma (ACP) is a subtype of craniopharyngioma, a neoplastic disease with a benign pathological phenotype but a poor prognosis in the sellar region. The disease has been considered the most common congenital tumor in the skull. Therefore, this article aims to identify hub genes that might serve as genetic markers of diagnosis, treatment, and prognosis of ACP.

Methods:
The procedure of this research includes the acquisition of public data, identification and functional annotation of differentially expressed genes (DEGs), construction and analysis of protein-protein interaction network, and the mining and analysis of hub genes by Spearman-rho test, multivariable linear regression, and receiver operator characteristic curve analysis. Quantitative real-time polymerase chain reaction was used to detect the level of mRNA of relative genes.

Results:
Among 2 datasets, a total of 703 DEGs were identified, mainly enriched in chemical synaptic transmission, cell adhesion, odontogenesis of the dentin-containing tooth, cell junction, extracellular region, extracellular space, structural molecule activity, and structural constituent of cytoskeleton. The protein-protein interaction network was composed of 4379 edges and 589 nodes. Its significant module had 10 hub genes, and SYN1, SYP, and GRIA2 were significantly down-regulated with ACP.

Conclusion:
In a word, we find out the DEGs between ACP patients and standard samples, which are likely to play an essential role in the development of ACP. At the same time, these DEGs are of great value in tumors’ diagnosis and targeted therapy and could even be mined as biological molecular targets for diagnosing and treating ACP patients.
New insight into the current study of high tibial osteotomy: A bibliometric analysis
Authors: Wei Cong , Xie Wenqing , Zhang Wenchao , Tang Ning , Su Yang , Jiang Buchan , Walschot Lucas H. , Xu Haijun , Li Yusheng , Huang Tianlong 
Published: September 2022

Background:
To analyze global trends in focus and funding of research related to high tibial osteotomy (HTO) and to identify the 100 most cited articles in this field.

Methods:
A Web of Science search was used to identify HTO publications in English-language scientific journals from January 1967 till February 3th, 2021. Results were filtered to the 100 most cited articles by reading the abstract or full-text paper. Information of these articles was recorded for further analysis. The 10 top-cited articles during the last 5 years and the 10 top-cited articles about HTO ranked by average citations per year were selected to predict research trends.

Results:
In all, 48 out of the 100 top-cited articles were published between 2000 and 2010. The United States of America was the primary contributor (n = 29) followed by Germany (n = 17) and Japan (n = 11). The total number of citations per article ranged from 65 to 563, median 108, mean 135 (standard deviation = 84). The American Journal of Bone and Joint Surgery accounted for 23 out of the 100 top-cited articles. Koshino T was the most cited author (603 citations). The most frequently highlighted study theme was prognostic research. Patient-based clinical research was the dominant study design (85%). The majority of articles (48 out of 100) were level IV evidence with a mean of 141 (standard deviation = 97) citations. Top-cited articles in the last 5 years focused on open wedge osteotomy.

Conclusion:
Technical optimization of open wedge osteotomy has emerged as the main area of research in HTO. More specifically, recent publications focus on the surgical technology, cartilage repair and new fixation devices. Besides, papers with a high level of evidence are needed for the development of HTO.
Relationship between mental disorders, psychotropic drugs, and constipation in psychiatric outpatients
Authors: Akasaka Kuni , Akasaka Fumi , Akasaka Tadashi , Okada Kazutake , Sadahiro Sotaro 
Published: September 2022

Constipation has been reported to be more common in patients with mental disorders than in the general population. However, its relationships with psychiatric diagnosis, medication, age, and sex have not been fully identified.
A total of 875 patients from the outpatient department were included in the study. As a retrospective observational study, the psychiatric diagnoses and psychotropic medications were examined based on the medical charts. Fecal conditions, including problems with defecation, abdominal pain, sense of incomplete evacuation, use of laxatives, frequency of defecation, and stool characteristics according to the Bristol Scale, were investigated.
The study included 368 males and 507 females, with median ages of 48 and 52 years, respectively. The most common psychiatric diagnoses were depressive disorders (33%), followed by anxiety disorders (19%). Females had significantly higher rates of problems with defecation and laxative use than males (P < .001, P < .0001, respectively). The frequency of laxative use increased significantly with age (P < .0001). The multivariate analyses revealed the close relationship between hypnotics and problems of defecation and that between hypnotics, antipsychotics, and laxative use.
In psychiatric outpatients, females had significantly higher rates of problems with defecation and laxative use than males. The use of laxatives significantly increased with age. Problems with defecation were significantly more common in patients taking hypnotics and laxative use was significantly more common in patients taking hypnotics and antipsychotics.