bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for Hirschsprung-associated enterocolitis following Soave: a retrospective study over a decade
Authors: xie chuanping , Chen Yajun , Yan Jiayu , Zhang Zhiyi , Wang Kai , Wang Zengmeng 
Published: July 2022

Abstract
Background: Hirschsprung-associated enterocolitis (HAEC), one of the most significant causes of morbidity and mortality for patients with Hirschsprung disease (HSCR), can occur before and after radical surgery. This study aims to identify the risk factors for HAEC before and after Soave.Methods: A retrospective study of 145 patients with HSCR treated between January 2011 and June 2021 was performed. Data were retrieved from the medical records. HAEC was defined as the presence of clinical signs of bowel inflammation and requiring treatment with intravenous antibiotics and rectal irrigation for at least two days in the outpatient or inpatient department. Univariate analysis and multivariate regression models were used to identify risk factors for developing pre-and postoperative HAEC.Results: The incidence of pre-and postoperative HAEC was 24.1% and 20.7%, respectively. More than 90% of the patients with the first episode of postoperative HAEC occurred within the first year after Soave. Long-segment aganglionosis was the independent risk factor for developing preoperative HAEC ([OR] 5.8, Cl 2.4-14.2, p＜0.001), while the history of preoperative HAEC was significantly associated with developing postoperative HAEC ([OR] 4.2, Cl 1.6-10.8, p=0.003).Conclusions: Long-segment aganglionosis was the independent risk factor for the development of preoperative HAEC, while the history of preoperative HAEC was strongly associated with developing HAEC after Soave.Type of study: a retrospective observational studyLevel of Evidence: Level Ⅲ
Analysing of some protein coding SNPs Of Homo sapiens cell division cycle 73 (CDC73) gene by using seven tools (bioinformatics study)
Authors: waheed zainab abdullah , Sarhan Nadia Habeeb , Hamzah Ahmed Ibrahim , Shaker Mustafa Mohammed 
Published: July 2022

Abstract
Background:Homo sapiens cell division cycle 73 (CDC73)Enables RNA polymerase II complex binding activity. Involved in several processes, including histone ubiquitination; negative regulation of cell population proliferation; and regulation of cell cycle G1/S phase transition. Located in cytosol and nucleoplasm. Part of Cdc73/Paf1 complex. Implicated in hyperparathyroidism and parathyroid carcinoma. Biomarker of carcinoma (multiple) and colorectal cancer,This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma.Aim of study:The study is aimed to show the affect of eight protein coding SNPs on human health and if it benign or neutral by using different gene and protein sites (SIFT,POLYPHEN2,I-MUTANT 3. 0,PROVEAN,and SNPS&GO).Results:the study shows 4 SNPs (50%) are damaging according to SIFT ,while the other 4 SNPs(50%) are TOLERATED ,while according to another bioiformatic tool called POLYPHEN2 there are 4 of SNPs (50%) Benign , 3 (37.5%) are Probably damaging and 1(12.5 %) Possibily damaging.The I-MUTANT 3.0 indicated 2(25 %) L Neutral stability and 5( 62.5 %) Large decrease stability while 1( 12.5 %) shows Large increase stability ,while PhD-SNP site shows 7(87.5%) ,1(12.5%) Neutral and Decrease correspondly,While Panther shows 8(100%) Neutral , but PROVEAN shows 6(75%) Neutral ,and 2(35%) are Deleterious ,while all of SNPs are Neutral according to SNPS&GO.Conclusions:This study has determined the SNPs of CDC73 gene which may contribute to the malfunction of its protein and ultimately leads to the CDC73 gene associated diseases.This study shows that there are many types of SNPs which result in gen modification but still having neutral affectWhile other SNPs that located at the exone location have disease leading effect and may result in a gene damage and progressive diseases
Akkermansia and the microbial metabolites butyric acid and deoxycholic acid play key roles in fecal microbiota transplantation for the treatment of campylobacteriosis in mice
Authors: Jiang Lai , Yuan Chun-Chun , Ye Wen-Xin , Huang Qi-Xin , Chen Zhuo , Wu Wen-Zi , Qian Li-Chun 
Published: July 2022

Abstract
BACKGROUND
Campylobacter jejuni (C. jejuni) is a common food-borne bacterial pathogen that can use the host's innate immune response to induce the development of colitis. There has been some research on the role of normal intestinal flora in C. jejuni-induced colitis, but the mechanisms that play a central role in resistance to C. jejuni infection have not been explored.
RESULTS
We first investigated the therapeutic effect of fecal microbiota transplantation (FMT) on C. jejuni infection. The results showed that FMT significantly reduced the inflammatory response and blocked the invasion of C. jejuni into the colonic tissue. We observed a significant increase in the abundance of Akkermansia in the colon of mice after FMT, as well as a significant increase in the levels of butyric acid and deoxycholic acid. We next demonstrated that oral administration of sodium butyrate or deoxycholic acid had a similar therapeutic effect. Further proteomic analysis showed that C. jejuni induced colitis mainly through activation of the PI3K-AKT signaling pathway and MAPK signaling pathway, whereas Akkermansia, the core flora of FMT, and the gut microbial metabolites butyric acid and deoxycholic acid both inhibited these signaling pathways to counteract the infection of C. jejuni and alleviate colitis. Finally, we verified the above idea by in vitro cellular assays. In conclusion, FMT is highly effective in the treatment of colitis caused by C. jejuni, with which Akkermansia and butyric and deoxycholic acids are closely associated.
CONCLUSION
The present study demonstrates that Akkermansia and butyric and deoxycholic acids are effective in the treatment of colitis caused by C. jejuni. This is the first time that Akkermansia has been found to be effective in fighting pathogens, which provides new ideas and insights into the use of FMT to alleviate colitis caused by C. jejuni and Akkermansia as a treatment for intestinal sexually transmitted diseases caused by various pathogens.
Are there differences in outcomes by race among women with metastatic triple negative breast cancer?
Authors: Oppong Bridget A. , Rolle Angel A. , Ndumele Amara , Li Yaming , Fisher James L. , Bhattacharyya Oindrila , Adeyanju Toyin , Paskett Electra D. 
Published: July 2022

Abstract
Purpose
African American (AA) women have higher breast cancer mortality rates than other groups, with Triple negative breast cancer (TNBC) being more common among AAs with a worse prognosis. Our study seeks to explore differences among Non-Hispanic Black (NHB) vs. White (NHW) women, with Stage IV TNBC, focusing on survival and treatment patterns.
Methods
Data from a specialized SEER Program dataset were examined for TNBC patients diagnosed with metastatic disease from 2012–2016. Neighborhood socioeconomic status (nSES) was defined using the Yost index based on census tract measures of income, education, housing, employment. Univariate and multivariate analyses were performed to evaluate receipt of surgery, radiation, and chemotherapy. Overall survival was evaluated using Kaplan-Meier curve and Cox proportional hazards model analysis.
Results
25,761 TNBC cases were identified with 1,420 being metastatic (5.5%). Bone was the most common site for metastasis, with patients’ age being 63.7 years for NHW vs. 59.5 years for NHB. NHB women had the highest percentage of low nSES (62.3% vs 29.3%; p-value = 0.001). On univariate analysis, fewer NHBs received radiation compared to NHWs (27.1 vs. 32.6%; p-value = 0.040). On multivariate analysis, all women were less likely to undergo treatment if unmarried (p-value < 0.01). NHB women had lower median survival compared to NHW women (13 vs. 15 months; p-value < 0.01). Receipt of surgery and chemotherapy reduced the risk of mortality (p-value < 0.01).
Conclusion
NHB women had lower median survival with metastatic TNBC. Race was associated with different treatment utilization. With a mortality differential between NHW and NHB women with metastatic TNBC, more investigation is needed to inform strategies to reduce this disparity.
Transferability of cost reduction from dual-tasks to a triple-task – A comparison of new and trained participants
Authors: Stefani Maximilian , Sauter Marian , Mack Wolfgang 
Published: July 2022

Abstract
Dual-task paradigms have dominated multitasking research in recent decades. However, recent research has shown that adding a third task to a standard dual-task is not just an add-on (Stefani et al., accepted). Response times and error rates increased more than twofold for the triple-task compared to dual-tasks. It seems that task coordination plays a crucial role in multiple task processing. In the present study, we sought to narrow the gap between lab-based and real-world applications, as the prediction of current cognitive models is still restricted. In Experiment 1, we trained participants in a location-hand and pitch-voice dual-task for up to nine sessions. In another eight sessions, this was followed by a triple-task training (location-hand, pitch-voice, and color-feet) in Experiment 2. In addition, participants with no prior knowledge of dual- or triple-task also trained the triple-task in eight sessions. In E2, all single-tasks and all possible dual-task combinations were also trained. We could demonstrate that participants who had previously trained dual-tasks benefited from them in E2. However, they could not gain a significant advantage in the new third single-task (responding to color stimuli with their foot). In the last session, no difference in training status could be detected anymore. In general, the higher demands on the coordination of subtasks seem to have a much greater impact on response times than in dual-tasks, which is given little to no consideration in the current multitasking research.
Abulia major and hypoactive delirium in COVID-19 reversed with methylprednisolone pulse therapy
Authors: Zanella Luiz Gonzaga Francisco de Assis Barros D’Elia , Zanella Luiz Gonzaga Francisco de Assis Barros D’Elia 
Published: July 2022

Abstract
Background: Sars-CoV-2 is a member of the genus Betacoronavirus like the two other coronaviruses viz. SARS-CoV (severe acute respiratory syndrome coronavirus) and MERS-CoV (Middle East respiratory syndrome coronavirus). SARS-CoV-2 infection has been associated with neuropsychiatric manifestations in acute and chronic COVID-19 (long COVID-19 syndrome), bringing social consequences and worsening people's quality of life. Overview: This article exemplifies two cases of neurological manifestations resulting from infection by SARS-CoV-2 that were reversed with methylprednisolone in a pulse therapy regimen. The first case presents a young patient with symptoms similar to those existing in patients with Alzheimer's disease, whose final and presumable diagnosis was Abulia major. The second case exemplifies an elderly person admitted to the hospital due to hypoactive delirium triggered by a urinary tract infection hypothesis. The final diagnosis was hypoactive delirium secondary to COVID-19, with urinary manifestations from SARS-CoV-2 kidney injury. Aim and Conclusion: The purpose of this article is to warn about phenomena related to COVID-19, whose treatment can be performed with high doses of corticosteroids and with drugs that act positively on dopaminergic and serotonergic pathways. Patient exams and more information are available in the Appendix of this article.
The Role of Soil Bunds Construction in Improving Soil Fertility In Jarso District, Western Ethiopia
Authors: Taye Samuel , Megersa Tolera , Yadeta Habtamu 
Published: July 2022

Abstract
To minimize severe soil erosion ,Physical soil and water conservation practices are being implemented by community campaign, NGOs and individually by farmers in Ethiopia, because it was resulting in reduction of crop production. Hence, the objective of this study was to assess the role of physical SWC practices mainly soil bund in improving soil fertility. 18 Soil sample were taken from purposively selected four years, two years and non-conserved field. To analyze the collected data; SPSS V.21 and SAS (9.1 Version) were used both for descriptive and inferential data analysis. The study Results showed that significant relationship ( p < 0.05) was found between the plot relative to the soil bund and levels of pH, Available phosphorus,(P-av),Available Potassium(K av),Cation Exchange Capacity(CEC),Elictrical Conductivity(EC,Ntot) and SOC,SOM and Exchangeable bases(Mg,Na,Ca,) which are higher in conserved land which improve soil fertility status of the study area. From the study it was concluded that the conservation practices age have significant effects on selected soil fertilities. As the age of soil bund increase, fertility gain shown increment. The un-expected out come in this study is that available phosphorus showed no significant difference between two years and four years conserved farmland with soil bund. To realize sustainable development goals, it needs integrated planning, selecting the desired SWC structures, implementing and maintaining of soil conservation measures to save its consequence on the life of community .
Sources, Pattern, and Health Impacts of PM2.5 in the Central Region of Bangladesh using PMF, SOM, and Machine Learning Techniques
Authors: Hassan Md Shareful , Bhuiyan Mohammad Amir Hossain , Iqbal S M Saify , Rahman Muhammad Tauhidur 
Published: July 2022

Abstract
The Particulate Matter 2.5 (PM2.5) is one of the major environmental and public health threats in Bangladesh. It is important to explore the relationship between PM2.5, and other variables to mitigate its adverse health impacts. This study aims to understand the sources, patterns, and health impacts of PM2.5 in five central districts of Bangladesh using fourteen variables. These variables have been analyzed by PMF, SOM, Machine Learning, and Multi-regression analysis. This paper has found that PM2.5 is correlated positively with NO (0.55), BC (0.45), CH4 (0.38), and NOx (0.22), while correlated negatively with Rainfall (-0.10), CO (-0.33), and SO2 (-0.24). In PMF modeling, the R2 values of settlement density (1.00), SO2 (0.99), DEM (0.94), Rainfall (0.77), NO (0.74) and Brickfield (0.66) have found as the most correlated variables. In this study, the dominant variables NO, CO, Rainfall, O3, AOT, CH4, and BC are found in Factor 1; SO2, settlement density, and DEM are found in Factor 2; and population density and brickfield are found in Factor 3. In SOM mapping, most of the variables are concentrated in the north-eastern, central, and south-eastern parts of the study area. The prediction of PM2.5 using machine learning is significant, showing reasonable R2 for Random Forest (0.85), Extreme gradient boosting (0.81), and Stepwise Linear (0.76). The impact of PM2.5 on child ARI is significant (p = 0.002, R2 = 0.75); while child mortality is not significant (p = 0.268; R2 = 0.55). These results will be useful for creating and implementing local and regional PM2.5 mitigation plans. Concern institutions and academia may also use these outputs for reducing health impacts, particularly child mortality and acute respiratory infections.
The mechanism of Icariside II on NSCLC/COVID-19 based on network pharmacology and molecular docking
Authors: Kong Qing , Zhu Huahe , Liu Baojun , Dong Jingcheng 
Published: July 2022

Abstract
Patients with non-small cell lung cancer (NSCLC) are susceptible to coronavirus disease-2019 (COVID-19), but related treatments are limited. Icariside II (IS), a metabolite of plant Epimedin, showed anti-inflammation and immunoregulation effects in various diseases. This study aimed to evaluate the effect and mechanisms of IS on NSCLC/COVID-19. Targets of NSCLC/COVID-19 were defined as the common targets of NSCLC and COVID-19. The clinical characteristics of NSCLC patients were collected from The Cancer Genome Atlas Program (TCGA) database and analyzed by the R package of “survival”, univariate and multivariate Cox proportional hazards regression model. Further, the targets in IS treatment of NSCLC/COVID-19 were defined as the overlapping targets of IS and NSCLC/COVID-19 targets. Gene Ontology (Go) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of the treatment targets found IS might affect the leucocyte migration, inflammation response, and active oxygen species metabolic process, and regulate the IL-17, TNF, and HIF-1 signaling pathway in NSCLC/COVID-19. Protein-protein interaction (PPI) network identified six hub targets of IS in the treatment of NSCLC/COVID-19 including F2, SELE, MMP1, MMP2, AGTR1, and AGTR2. Molecular docking showed above target proteins had a great binding degree to IS. Our finding indicated that IS exerts therapeutic effects in NSCLC patients infected with COVID-19, supporting a further pre-clinical study to validate the related effect and underlying mechanism.
A numerical study on planar gradient acoustic impedance matching for guided ultrasonic wave detection
Authors: Rottmann Max , Roloff Thomas , Rauter Natalie , Rittmeier Liv , Sinapius Michael , Weber Wolfgang E. 
Published: July 2022

Abstract
Increasing the service-life of engineering structures such as e. g. airplanes is a major issue in order to enhance their cost-effectiveness and to reduce the carbon footprint. One possibility to achieve this goal is to determine the current (structural) health state and to derive respective measures e. g. in order to increase the structure’s technical reliability.For doing so, a structural health monitoring system consisting of both an actuator and a sensor network may be applied. Whereas the actuator induces a wave-field of guided ultrasonic waves, the measuring data of the sensors allow to determine the health state of the respective structure. However, both actuators and sensors in most cases distort thesewave fields. This distortion may lead to false-detection of damages: both the number and severity of damages may be over- or underestimated. The former leads to an unnecessary high effort for retrofitting the structure whereas the latter reduces the structure’s technical reliability. Several measures exist in order to avoid such false-detections. In thepresent contribution, focus is set on reducing the distortion of the wave field which is caused by a sensor. The reduced distortion of the wave field is achieved by an acoustic impedance matching with a functionally graded material which is based on a mechanical model. The approach additionally results in amplified measuring signals of the sensor. Bymeans of a numerical study the applicability of the proposed approach is shown.
Network pharmacology-based strategy to investigate the molecular target and mechanism of Jiawei Linggui Zhugan decoction in the treatment of obesity
Authors: Wang Ning , Chen Hongda , Ye Zhiyu , Cao Nan , Mo Binyan , Qin Jian , Tan Li 
Published: July 2022

Abstract
Background. Jiawei Ling Gui Zhu Gan Decoction (JW-LZD) is based on LingguiZhugan Decoction (LZD) and adds eight traditional Chinese medicines: Codonopsispilosula, Astragalus membranaceus, Yam, Epimedium, Morinda officinalis, TangerinePeel, Pinellia ternata and Coix Seed, which can be used for the treatment of obesityin the clinical. In this study, we determined the molecular targets and mechanismsinvolved in obesity treatment through network pharmacological analysis, andmolecular docking technology. Material and Methods. Related compounds wereobtained from the TCMSP.Oral bioavailability and drug-likeness were screened usingpharmacokinetic criteria. Molecular targets were identified in the drug-bank databaseand compared with obesity disease differential genes with P < 0.05 and ∣ log2FC >0.5 obtained in the GEO-database to obtain cross genes and construct the TCMcompound disease regulation network. After constructing PPI, Go, and KEGGanalyses, the key active components and target genes were selected. Moleculardocking was carried out using AutoDock, and the best binding target was selected toselect the best binding target for molecular docking. Results. A total of 248 potentialcompounds and 30 strongly associated JW-LZD targets were identified. Pathwayenrichment analysis showed that putative JW-LZD targets mostly participated inadenylate cyclase-activating adrenergic receptor signaling, adrenergic receptorsignaling, regulation of signal receptor activity, coagulation, and other metabolicrelated biological processes. The molecular docking results showed that the key JWLZDcomponents have good potential to combine with the target genes ADRB2,ADRA2A, ADRA2C, CHEK1, CHEK2, and DGAT2. Conclusion. Our findingssuggest that JW-LZD prevent obesity through the molecular mechanisms predicted bynetwork pharmacology, providing a way to develop new combination medicines forobesity.
VALIDACIÓN DE CUESTIONARIO SOBRE AUTORREGULACIÓN DEL APRENDIZAJE EN LA FORMACIÓN INICIAL DOCENTE
Authors: Aguilar Davis Virginia , Hernández Rodríguez Carlos 
Published: July 2022

La presente investigación, de diseño instrumental y enfoque cuantitativo, se realizó con la finalidad de analizar la validez del Cuestionario de Autorregulación del Aprendizaje en la Formación Inicial Docente, conformado por 84 ítems y elaborado a partir de un modelo propio diseñado bajo el enfoque sociocognitivo. Con este objetivo se recurrió a una muestra de 360 estudiantes de cinco licenciaturas distintas en una Institución de Educación Superior de México. Mediante el juicio de expertos se obtuvo la validez de contenido, mientras que el índice de Confiabilidad Alfa de Cronbach dio como resultado .942. Las pruebas de Kaiser-Meyer-Olkin y esfericidad de Bartlett, confirmaron la viabilidad de realizar el Análisis Factorial de Componentes principales con rotación Varimax, resultando tres factores con una distribución de ítems que no corresponde al modelo original, lo cual puede deberse a la compleja estructura del cuestionario. Se concluye que el instrumento cuenta con validez de contenido, es congruente con su diseño y altamente confiable, sin embargo, se recomienda corroborar la validez de constructo mediante otras pruebas, seccionando el instrumento en las fases o áreas que lo conforman, o aplicándolo en otras poblaciones procedentes de instituciones tanto públicas como privadas, por ejemplo.