bluuebunny/crossref_metadata_2025_split huggingface dataset:
ResearchGate Metrics’ Behavior and Its Correlation with RG Score and Scopus Indicators
Authors: Valizadeh-Haghi Saeideh , Nasibi-Sis Hamed , Shekofteh Maryam , Rahmatizadeh Shahabedin 
Published: March 2022

Objective: Social networking sites are appropriate tools for sharing and exposing scientific works to increase citations. The objectives of the present study are to investigate the activity of Iranian scholars in the medical sciences in ResearchGate and to explore the effect of each of the four ResearchGate metrics on the RG score. Moreover, the citation metrics of the faculty members in Scopus and the relationship between these metrics and the RG score were explored.
Methods: The study population included all SBMU faculty members who have profiles in ResearchGate (N=950). The data were collected through ResearchGate and Scopus in January 2021. The Spearman correlation coefficient was applied to examine the relationship between ResearchGate metrics and Scopus indicators as well as to determine the effect of each ResearchGate metric on the RG score.
Results: The findings revealed that the publication sharing metric had the highest correlation (0.918) with the RG score and had the greatest impact on it (p-value <0.001), while the question asking metric showed the lowest correlation (0.11). Moreover, there was a significant relationship between the RG score and Scopus citation metrics (p-value <0.05). Furthermore, all four RG metrics had a positive and significant relationship with Scopus indicators (p-value <0.05), in which the number of shared publications had the highest correlation compared to other RG metrics.
Conclusion: Researchers’ participation in the ResearchGate social network is effective in increasing citation indicators. Therefore, more activity in the ResearchGate social network may have favorable results in improving universities’ ranking.
Is Intravenous Fluid Therapy Associated with Cerebral Oedema in Paediatric Diabetic Ketoacidosis? Literature Review and Critical Appraisal of Evidence
Authors: Taiwo Akhigbe, 
Published: March 2022

Objective: The ongoing controversy regarding fluid management in pediatric diabetic ketoacidosis (DKA) has necessitated this review of whether aggressive fluid therapy aggravates the risk of cerebral edema. The amount of fluid administered in pediatric DKA is estimated with a weight-based formula for correction of deficit, dehydration, and fluids maintenance. Cerebral edema is known to occur with hyperosmolar treatment or controlled hyperventilation treatment for cerebral edema.
Methods: A literature search was conducted using EMBASE, Medline, and Cochrane databases for systematic reviews and original articles published in the last 18 years from the year 2000 to 2018 using search words individually or in combination, Inclusion criteria were studies limited to pediatric patients treated for diabetic ketoacidosis. In addition, a critical appraisal of the most current evidence was performed.
Results: After the literature search, 913 articles were identified from Medline, Embase, and Cochrane databases. Non-relevant studies, non-full text studies, and studies that lacked control groups or articles that were duplicated were excluded leaving a final total of five full test articles for literature review and critical appraisal of evidence.
Conclusion: Almost all the studies showed that cerebral edema was associated with severe acidosis and prerenal azotemia in initial DKA presentation and only one case-control study showed a significant correlation with a higher volume of intravenous fluid therapy within the first three hours. The PECARN study put to rest age-long controversy and traditional teaching that aggressive fluid therapy in pediatric DKA may be responsible for cerebral edema with the conclusion that neither rate of fluid administration nor sodium chloride content significantly influenced neurological outcomes in Pediatric DKA
Knowledge Attitude and Practice of Dental Practitioners towards Palliative Dental Care: A Cross-sectional Questionnaire Study
Authors: Pereira Christina , Acharya Siddharth , Pereira Treville , Shetty Subraj , Gotmare Swari , Kallianpur Ruchika 
Published: March 2022

Introduction: Palliative care is active total care of patients whose disease is not responsive to curative treatment. In a multidisciplinary approach for rendering palliative care, a dentist’s role is vital, but overlooked. Oral cavity is home to numerous microorganisms aggravating disease process. A trained dentist helps treat and manage oral manifestations of systemic diseases from diagnosis to relief from pain and discomfort. Dental expression in palliative care is extended dental services to provide preeminent feasible oral care to terminally ill or advanced diseased patients. Oral conditions impact quality of life of patients and initiation and progression of these lesions may be related to the succession of disease, its treatment or both.
Objectives: To evaluate the knowledge, attitude and practice of dental practitioners towards palliative dental care.
Materials and Methods: A cross-sectional observational questionnaire-based study conducted on 50 dental academicians and practitioners across Mumbai which included specialists in Oral Medicine, Oral Surgery, Prosthodontics and Oral Pathology. A closed-ended, pre-tested, self-administered questionnaire would be prepared for the study.
Results: All participants completed their masters in dental surgery. Eighty five percent participants had come across patients requiring palliative care. All except 4 male and 1 female respondent acknowledged importance of palliative care in dentistry. 56.8% participants were aware of hospitals providing palliative dental care. All participants considered palliative care to be interdisciplinary. 94 participants believed dental problems to be common in palliative care. Majority respondents suggested a sugar-free diet while 19 proposed a spicy diet for cases requiring palliative care. Fluoride based mouthwash was recommended by 40 participants and 30 recommended chlorhexidine based while 10 preferred alcohol-based. While 70 participants had not attended any seminars, workshops, symposiums and/ or conferences on palliative care, 80 were willing to do so.
WEBSITE AS AN COMMUNICATION TOOL AND BRANDING STRATEGY IN TELECOMMUNICATION COMPANIES
Authors: Martini Erni , Wibowo Lili Adi , Rahayu Agus , Hurriyati Ratih 
Published: March 2022

This research had the purpose of investigating the utilization of a company's official website as a com­munication medium and for online branding purposes in the telecommunication industry in Indonesia. This study used a population of official websites from seven telecommunication companies in Indonesia. The indicators that had been used to analyze website content, website ease of use, and website interactivity. The results of this study showed that 100% of telecommunication companies in Indonesia had a website that can be used as an online branding strategy. The indicators that were mostly used by these companies for online branding were website content (100%) and website ease of use (93.65%), while the use of website interactivity (53%) still needed to be maximized. The findings of this study were useful in revealing how tele­com­mu­ni­cations companies in developing countries used their websites as a communication medium for online branding
MANIPULAÇÃO DE PLANO OCLUSAL NO SENTIDO HORÁRIO EM CIRURGIA ORTOGNÁTICA: RELATO DE CASO.
Authors: Tourinho Lais Fernandes , Calvacante Weber Céo , Neto Antônio Irineu Trindade , Gaeta Noeele Fraga Matos , Damasceno Milena Merces 
Published: March 2022

Objetivo: O presente trabalho consiste em um relato de caso clínico sobre amanipulação do plano oclusal em cirurgia ortognática. Descrição do caso: O caso apresentado trata de um paciente do sexo feminino que apresentava padrão facial classe III, com discrepância oclusal antero-posterior de 4 mm. Tendo em vista que um avanço de maxila ou recuo de mandíbula ou com-binação dos dois movimentos nesta magnitude parecia ser insuficiente parapromover bom resultado estético, foi utilizada a rotação do plano oclusal do complexo maxilomandibular no sentido horário. A rotação horária teve comoponto de fulcro aproximadamente a espinha nasal anterior e obteve comoresultados o aumento dos ângulos do plano oclusal, do plano mandibular edo incisivo inferior; retração da ponta do incisivo superior; e diminuição daangulação dos incisivos superiores e da projeção do mento. Conclusão: Notratamento cirúrgico foram alcançados resultados estéticos satisfatórios sem odesenvolvimento de implicações sobre articulações temporomandibulares eespaço aéreo posterior.
OBTENÇÃO DE MODELOS EM ORTODONTIA – UM GUIA CLÍNICO PARTE 2: MODELAGEM
Authors: Bittencourt Marcos Alan Viera , Sobral Márcio Costa 
Published: March 2022

Os modelos de estudo, em Ortodontia, permitem a realização de uma análise tridimensional da oclusão do paciente, possibilitando a observação de aspec- tos de fundamental importância, como as inclinações axiais dos dentes, seu alinhamento nas respectivas arcadas, más posições individuais, assimetrias, desvios de linha média, formato do palato, enfim, uma série de detalhes que poderiam passar despercebidos ao exame clínico. Além disso, constituem valiosa fonte de registro legal, sendo de grande utilidade na comparação das diferentes fases do tratamento, na transferência de pacientes e no reestudo de casos anteriormente tratados. Dada a sua importância, parece óbvio que estes devem reproduzir perfeitamente a condição existente na boca. Para tal, é indispensável que o profissional tenha conhecimento profundo a respeito da técnica e dos materiais envolvidos nas duas principais etapas do processo, a moldagem precisa da região de interesse e o preenchimento adequado da mesma. O objetivo deste trabalho, no presente capítulo, é revisar a literatura existente sobre a técnica de modelagem em Ortodontia e descrever um pro- tocolo para a adequada realização desta etapa.
BIOSSEGURANÇA EM ODONTOLOGIA E OCORRÊNCIA DE ACIDENTES DE TRABALHO: A PERCEPÇÃO DE ESTUDANTES DE UMA INSTITUIÇÃO FEDERAL DE ENSINO SUPERIOR
Authors: Rabelo Rosângela , Viana Maria Isabel 
Published: March 2022

Objetivo: Avaliar a percepção de estudantes de uma Instituição de Ensino Superior sobre Biossegurança em Odontologia e ocorrência de acidentes de trabalho. Material e Métodos: Estudo descritivo e exploratório, envolvendo alunos entre o 4º e 11º semestres do Curso de Odontologia de uma Institui- ção de ensino Superior, utilizando para coleta de dados questionário semi-estruturado, auto-aplicável, organizado em partes: dados sociodemográficos e acadêmicos; situação vacinal; aspectos de biossegurança; exposição ocupa- cional e acidentes de trabalho. Resultados: Os resultados demonstraram baixa cobertura vacinal contra hepatite B (83,8%) e outras vacinas; conhecimento insuficiente e inadequado quanto ao cumprimento das precauções-padrão (62,8%); elevada ocorrência de acidentes (37%). O semestre em curso foi o único fator associado à ocorrência de acidentes (p-valor<0,001). Em relação aos protocolos pós-exposição, 56% referiram não ter conhecimento, embora 65,9% reconheçam que as medidas devem ser adotadas nas primeiras 02 ho- ras. Conclusão: Elevado percentual dos estudantes apresentou conhecimento em relação às formas de transmissão e prevenção da Hepatite B, contudo os acidentes ocorreram com maior frequência (p<0,001) entre os alunos do 8o ao 11o semestre. Pode-se analisar que os alunos consideram-se seguros na prática clínica e por isto negligenciam as precações padrão.
Prognostic value of serum/plasma neurofilament light chain for COVID‐19‐associated mortality
Authors: Masvekar Ruturaj R. , Kosa Peter , Jin Kimberly , Dobbs Kerry , Stack Michael A. , Castagnoli Riccardo , Quaresima Virginia , Su Helen C. , Imberti Luisa , Notarangelo Luigi D. , Bielekova Bibiana 
Published: March 2022

AbstractObjectiveGiven the continued spread of coronavirus 2, the early predictors of coronavirus disease 19 (COVID‐19) associated mortality might improve patients' outcomes. Increased levels of circulating neurofilament light chain (NfL), a biomarker of neuronal injury, have been observed in severe COVID‐19 patients. We investigated whether NfL provides non‐redundant clinical value to previously identified predictors of COVID‐19 mortality.MethodsWe measured serum or plasma NfL concentrations in a blinded fashion in 3 cohorts totaling 338 COVID‐19 patients.ResultsIn cohort 1, we found significantly elevated NfL levels only in critically ill COVID‐19 patients. Longitudinal cohort 2 data showed that NfL is elevated late in the course of the disease, following the two other prognostic markers of COVID‐19: decrease in absolute lymphocyte count (ALC) and increase in lactate dehydrogenase (LDH). Significant correlations between ALC and LDH abnormalities and subsequent rise of NfL implicate that the multi‐organ failure is the most likely cause of neuronal injury in severe COVID‐19 patients. The addition of NfL to age and gender in cohort 1 significantly improved the accuracy of mortality prediction and these improvements were validated in cohorts 2 and 3.InterpretationA substantial increase in serum/plasma NfL reproducibly enhanced COVID‐19 mortality prediction. Combined with other prognostic markers, such as ALC and LDH that are routinely measured in ICU patients, NfL measurements might be useful to identify the patients at a high risk of COVID‐19‐associated mortality, who might still benefit from escalated care.
Clinical and diagnostic features of anti‐neurofascin‐155 antibody‐positive neuropathy in Han Chinese
Authors: Wang Wenqing , Liu Chang , Li Wei , Zhang Dong , Shan Yi , Zheng Jinfan , Shan Jingli , Zhao Yuying , Yan Chuanzhu , Wang Qinzhou 
Published: March 2022

AbstractObjectiveTo investigate the clinical features of Han Chinese patients with anti‐neurofascin‐155 (NF155) antibody‐positive neuropathy.MethodsWe screened 194 patients with peripheral neuropathy for NF155 antibodies using a cell‐based assay (CBA) and teased‐fiber immunofluorescence assay. We summarized the clinical findings of seropositive patients.ResultsThe sera from 17 patients reacted to human embryonic kidney 293 cells transfected with NF155. Eleven of these patients had the immunoglobulin G (IgG) 4 isotype, a younger onset age, tremor, higher levels of cerebrospinal fluid protein, a larger diameter of the lumbosacral nerve root on magnetic resonance imaging, and the distal demyelinating symmetric phenotype. Most patients responded to steroids and rituximab. For the remaining six seropositive patients in CBA, the predominant antibody isotype was IgG3, IgG1, or undetectable, and only one patient with IgG3 showed a positive result in the teased‐fiber immunofluorescence assay. These patients did not share the typical features displayed by patients with the IgG4 isotype.InterpretationIn the Han Chinese population, a significant proportion of patients who fulfilled the criteria for chronic inflammatory demyelinating polyradiculoneuropathy diagnosis had anti‐NF155 IgG4 antibody‐positive neuropathy and displayed specific phenotypes. Ambiguous staining patterns may appear, and the potential for false positivity should be considered. For patients who presented with specific phenotypes, identifying antibodies and subtypes involved a significant laboratory workup.
Association Between Metabolically Different Adiposity Subtypes and Osteoarthritis: A Mendelian Randomization Study
Authors: Mulugeta Anwar , Eshetie Tesfahun C. , Kassie Gizat M. , Erku Daniel , Mekonnen Alemayehu , Lumsden Amanda , Hyppönen Elina 
Published: March 2022

ObjectiveIn this Mendelian randomization (MR) study, the objective was to investigate the causal effect of metabolically different adiposity subtypes on osteoarthritis.MethodsWe performed 2‐sample MR using summary‐level data for osteoarthritis (10,083 cases and 40,425 controls) from a genome‐wide association using the UK Biobank, and for site‐specific osteoarthritis from the Arthritis Research UK Osteoarthritis Genetics consortium. We used 3 classes of genetic instruments, which all increase body mass index but are associated with different metabolic profiles (unfavorable, neutral, and favorable). Primary analysis was performed using inverse variance weight (IVW), with additional sensitivity analysis from different MR methods. We further applied a nonlinear MR using UK Biobank data to understand the nature of the adiposity–osteoarthritis relationship.ResultsGreater metabolically unfavorable and metabolically neutral adiposity were associated with higher odds of osteoarthritis (IVW odds ratio [OR] 1.56 [95% confidence interval (95% CI) 1.31, 1.85] and OR 1.60 [95% CI 1.15, 2.23], respectively). The estimate for the association between metabolically favorable adiposity and osteoarthritis was similar, although with notable imprecision (OR 1.55 [95% CI 0.70, 3.41]). Using site‐specific osteoarthritis, metabolically unfavorable, neutral, and favorable adiposity were all associated with higher odds of knee osteoarthritis (OR 1.44 [95% CI 1.04, 1.98], OR 2.28 [95% CI 1.04, 4.99], and OR 6.80 [95% CI 2.08, 22.19], respectively). We found generally consistent estimates with a wider confidence interval crossing the null from other MR methods. The nonlinear MR analyses suggested a nonlinear relationship between metabolically unfavorable adiposity and osteoarthritis (Pnonlinear = 0.003).ConclusionMetabolic abnormalities did not explain the association between greater adiposity and the risk of osteoarthritis, which might suggest that the association is largely due to a mechanical effect on the joints.
Coupled Focused Acoustic Vortices Generated by Degenerated Artificial Plates for Acoustic Coded Communication
Authors: Li Xin‐Rui , Wu Da‐Jian , Luo Yan‐Chun , Yao Jie , Liu Xiao‐Jun 
Published: March 2022

AbstractAcoustic vortices (AVs) show great significance in acoustic communication. However, the lack of confidentiality and the cross‐talks in communications based on traditional AVs remain problems. Here, a degenerated centrosymmetric circular hole plate (DCHP) is designed to generate coupled focused acoustic vortices (CFAVs) with pure orbital angular momentums (OAMs) in both air and water. When an acoustic plane wave transmits through DCHP, two focused acoustic vortices (FAVs) with opposite topological charges are produced simultaneously, and the coupling between them results in a focused acoustic petal beam (FAPB). The OAM of the CFAV can be simply modulated by the angular interval of the adjacent holes on DCHP and the CFAV can be focused at any distances by adjusting the positions of holes. The DCHPs are demonstrated to be able to generate FAPBs numerically and experimentally. Furthermore, 8 FAPBs with different OAMs are set as 8 bases to represent 8 bits of ASCII binary code, and the information encoding and decoding for acoustic communication are realized in water using them. The proposed DCHP provides a convenient method to achieve CFAVs, which may be helpful to enhance the security, reduce the false information, and increase the information capacity in acoustic communication.
Characterization of Miniature Probes for Cryosurgery, Thermal Ablation, and Irreversible Electroporation on Small Animals
Authors: Ranjbartehrani Pegah , Etheridge Michael , Ramadhyani Satish , Natesan Harishankar , Bischof John , Shao Qi 
Published: March 2022

AbstractFocal therapies, including cryosurgery, thermal ablation, and irreversible electroporation (IRE) are widely used in the treatment of cancer and other diseases, aimed at exposing cancer cells to extreme physical conditions leading to cell death. Focal ablation outcomes are extensively studied in small animal preclinical models, such as mice; however, robust engineering characterization of these treatments is largely lacking, due in a large part to the lack of control in applying clinical devices (cm scale) to mouse tumors (mm scale). To address this issue, miniaturized probes are designed and built for controlled application of cryosurgery, thermal ablation, and IRE and their performance is evaluated using ex vivo porcine liver tissue and an in vivo MC‐38 tumor model. These experimental results are compared to simulated conditions in heat transfer (cryosurgery and thermal ablation) and electrical (IRE) models. Agreements of physical quantities between measurement and modeling are shown for all the focal therapy cases. The in vivo outcome is further correlated with tumor growth delay. The characterization improves the understanding of the energy dose to create tissue damage, therefore enables to better understand outcomes in preclinical studies and predict and optimize the outcome of future clinical procedures.
Microbial Metabolite Inspired β‐Peptide Polymers Displaying Potent and Selective Antifungal Activity
Authors: Zhang Donghui , Shi Chao , Cong Zihao , Chen Qi , Bi Yufang , Zhang Junyu , Ma Kaiqian , Liu Shiqi , Gu Jiawei , Chen Minzhang , Lu Ziyi , Zhang Haodong , Xie Jiayang , Xiao Ximian , Liu Longqiang , Jiang Weinan , Shao Ning , Chen Sheng , Zhou Min , Shao Xiaoyan , Dai Yidong , Li Maoquan , Zhang Lixin , Liu Runhui 
Published: March 2022

AbstractPotent and selective antifungal agents are urgently needed due to the quick increase of serious invasive fungal infections and the limited antifungal drugs available. Microbial metabolites have been a rich source of antimicrobial agents and have inspired the authors to design and obtain potent and selective antifungal agents, poly(DL‐diaminopropionic acid) (PDAP) from the ring‐opening polymerization of β‐amino acid N‐thiocarboxyanhydrides, by mimicking ε‐poly‐lysine. PDAP kills fungal cells by penetrating the fungal cytoplasm, generating reactive oxygen, and inducing fungal apoptosis. The optimal PDAP displays potent antifungal activity with minimum inhibitory concentration as low as 0.4 µg mL−1 against Candida albicans, negligible hemolysis and cytotoxicity, and no susceptibility to antifungal resistance. In addition, PDAP effectively inhibits the formation of fungal biofilms and eradicates the mature biofilms. In vivo studies show that PDAP is safe and effective in treating fungal keratitis, which suggests PDAPs as promising new antifungal agents.
Long‐term eltrombopag for bone marrow failure depletes iron
Authors: Young David J. , Fan Xing , Groarke Emma M. , Patel Bhavisha , Desmond Ronan , Winkler Thomas , Larochelle Andre , Calvo Katherine R. , Young Neal S. , Dunbar Cynthia E. 
Published: March 2022

AbstractEltrombopag (EPAG) has been approved for the treatment of aplastic anemia and for immune thrombocytopenia, and a subset of patients require long‐term therapy. Due to polyvalent cation chelation, prolonged therapy leads to previously underappreciated iron depletion. We conducted a retrospective review of patients treated at the NIH for aplastic anemia, myelodysplastic syndrome, and unilineage cytopenias, comparing those treated with EPAG to a historical cohort treated with immunosuppression without EPAG. We examined iron parameters, duration of therapy, response assessment, relapse rates, and common demographic parameters. We included 521 subjects treated with (n = 315) or without EPAG (n = 206) across 11 studies with multiyear follow‐up (3.6 vs. 8.5 years, respectively). Duration of EPAG exposure correlated with ferritin reduction (p = 4 × 10−14) regardless of response, maximum dose, or degree of initial iron overload. Clearance followed first‐order kinetics with faster clearance (half‐life 15.3 months) compared with historical responders (47.5 months, p = 8 × 10−10). Risk of iron depletion was dependent upon baseline ferritin and duration of therapy. Baseline ferritin did not correlate with response of marrow failure to EPAG or to relapse risk, and timing of iron clearance did not correlate with disease response. In conclusion, EPAG efficiently chelates total body iron comparable to clinically available chelators. Prolonged use can deplete iron and ultimately lead to iron‐deficiency anemia mimicking relapse, responsive to iron supplementation.