bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low Incidence of hepatic sinusoidal obstruction syndrome/veno-occlusive disease in adults undergoing allogenic stem cell transplantation with prophylactic ursodiol and low-dose heparin
Authors: Stutz Lina , Halter Jörg P. , Heim Dominik , Passweg Jakob R. , Medinger Michael 
Published: January 2022

AbstractHepatic sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD) is a complication after allogenic hematopoietic stem-cell transplantation (allo-HSCT) with high mortality. The purpose of this study was to assess the incidence and outcome of SOS in patients after allo-HSCT with the impact of ursodeoxycholic acid (UDCA) and low-dose heparin as SOS prophylaxis. Out of 1016 patients, 23 developed SOS, with a cumulative incidence of 2.3% (95% CI 1.3–3.3) 6 months after HSCT. Approximately one quarter of these patients (26.1%) had late-onset SOS. A high proportion were very severe SOS cases (74%), and 83% of the patients were treated with defibrotide (DF). In multivariate analysis, advanced disease (p = 0.003), previous HSCT (p = 0.025) and graft versus host disease (GvHD) prophylaxis by post-transplant cyclophosphamide (PTCy) (p = 0.055) were associated with the development of SOS. The 1-year overall survival (OS) was significantly lower in the SOS group compared to patients without SOS (13% versus 70%, p = 0.0001). In conclusion, we found a low incidence of SOS in patients receiving low-dose heparin and UDCA prophylactically, but among SOS patients, a high mortality. Low-dose heparin and UDCA might be a prophylactic approach for SOS.
Overexpression of NMNAT3 improves mitochondrial function and enhances antioxidative stress capacity of bone marrow mesenchymal stem cells via the NAD+-Sirt3 pathway
Authors: Wang Tao , Zhang Fei , Peng Wuxun , Wang Lei , Zhang Jian , Dong Wentao , Tian Xiaobin , Ye Chuan , Li Yanlin , Gong Yuekun 
Published: January 2022

Abstract
Oxidative stress damage is a common problem in bone marrow mesenchymal stem cell (BMSC) transplantation. Under stress conditions, the mitochondrial function of BMSCs is disrupted, which accelerates senescence and apoptosis of BMSCs, ultimately leading to poor efficacy. Therefore, improving mitochondrial function and enhancing the antioxidative stress capacity of BMSCs may be an effective way of improving the survival rate and curative effect of BMSCs. In the present study, we have confirmed that overexpression of nicotinamide mononucleotide adenylyl transferase 3 (NMNAT3) improves mitochondrial function and resistance to stress-induced apoptosis in BMSCs. We further revealed the mechanism of NMNAT3-mediated resistance to stress-induced apoptosis in BMSCs. We increased the level of nicotinamide adenine dinucleotide (NAD+) by overexpressing NMNAT3 in BMSCs and found that it could significantly increase the activity of silent mating type information regulation 2 homolog 3 (Sirt3) and significantly decrease the acetylation levels of Sirt3-dependent deacetylation-related proteins isocitrate dehydrogenase 2 (Idh2) and Forkhead-box protein O3a (FOXO3a). These findings show that NMNAT3 may increase the activity of Sirt3 by increasing NAD+ levels. Our results confirm that the NMNAT3-NAD+-Sirt3 axis is a potential mechanism for improving mitochondrial function and enhancing antioxidative stress capacity of BMSCs. In the present study, we take advantage of the role of NMNAT3 in inhibiting stress-induced apoptosis of BMSCs and provide new methods and ideas for breaking through the bottleneck of transplantation efficacy of BMSCs in the clinic.
H2O2 down-regulates SIRT7’s protective role of endothelial premature dysfunction via microRNA-335-5p
Authors: Liu Yixin , Yang Jinyu , Yang Xi , Lai Peng , Mou Yi , Deng Juelin , Li Xinyi , Wang Hui , Liu Xiaolei , Zhou Lixing , Deng Linghui , Xu Ziqi , Xiao Chun , Dong Birong 
Published: January 2022

Abstract
Endothelial senescence is believed to constitute the initial pathogenesis of the atherosclerotic cardiovascular disease (ASCVD). MicroRNA-335-5p (miR-335-5p) expression is significantly up-regulated in oxidative stress-induced endothelial cells (ECs). Sirtuin7 (SIRT7) is considered to prevent EC senescence, yet data on its response to ASCVD risk factors are limited. The present study analyzed the elevated levels of miR-335-5p and the decreased levels of SIRT7 in human umbilical vein endothelial cells (HUVECs), and found that high glucose, tumor necrosis factor-α (TNF-α), and H2O2 are the three contributing factors that induced cellular senescence. The current study also assessed premature endothelial senescence and decreased proliferation, adhesion, migration, and nitric oxide (NO) secretion in HUVECs with these risk factors together with SIRT7–siRNA transfection. It found that the miR-335-5p inhibitor attenuated the down-regulation of SIRT7 expression induced by oxidative stress in HUVECs, and SIRT7 overexpression exerts a rescue effect against miR-335-5p-induced endothelial dysfunction. Furthermore, the direct binding of miR-335-5p to SIRT7 was observed in human embryonic kidney cells 293T (HEK 293T). Therefore, it can be inferred that miR-335-5p down-regulates the expression of SIRT7 in human cells. Current findings may provide deeper insights into the underlying mechanisms of endothelial senescence and potential therapeutic targets of ASCVD as well as other age-related diseases.
Tandem mass tag-based proteomics analysis of type 2 diabetes mellitus with non-alcoholic fatty liver disease in mice treated with acupuncture
Authors: Wang Guan , Li Mengyuan , Yu Shuo , Guan Mengqi , Ma Shiqi , Zhong Zhen , Guo Yihui , Leng Xiangyang , Huang Haipeng 
Published: January 2022

Abstract
Objective: To explore the proteomics profiles of hepatocytes of mice treated with acupuncture for type 2 diabetes mellitus (T2DM) with non-alcoholic fatty liver disease (NAFLD). Methods: We used a Tandem mass tag (TMT)-based quantitative proteomics approach to identify proteins with potential molecular mechanisms associated with acupuncture interventions for T2DM with NAFLD. Results: Acupuncture effectively improved body weight, blood glucose, and insulin levels in T2DM with NAFLD mouse models and reversed steatosis within hepatocytes. Quantitative TMT-based proteomics analysis identified a total of 4710 quantifiable proteins and 1226 differentially expressed proteins (DEPs) in the model control group (MCG) compared with the normal control group (NCG). The Acupuncture Treatment Group (ATG) presented in 122 DEPs was compared with the MCG group. We performed a bioinformatics analysis, which revealed that DEPs enriched in the KEGG pathway after acupuncture treatment were mainly involved in the PPAR signaling pathway, fatty acid biosynthesis, fatty acid metabolism, fatty acid elongation, fat digestion and absorption. We used parallel reaction monitoring (PRM) technology to explore the association of aldehyde oxidase 1 (Aox1), acyl-coenzyme A thioesterase 2 (Acot2), perilipin-2 (Plin2), acetyl-CoA carboxylase 1 (Acc), NADP-dependent malic enzyme (Me1), fatty acid synthase (Fasn), ATP-citrate synthase (Acly), fatty acid-binding protein, intestinal (Fabp2) with lipid synthesis, fatty acid oxidation, and hepatocyte steatosis. Conclusions: Our results show that acupuncture can regulate the protein expression of T2DM in the NAFLD mice model, and can effectively improve hepatocyte steatosis, and has potential benefits for the clinical treatment of this disease.
Determining the Relationship Between Hyoid Bone Kinematics and Airway Protection in Swallowing
Authors: Smaoui Sana , Peladeau-Pigeon Melanie , Steele Catriona M. 
Published: January 2022

Purpose:
Research remains equivocal regarding the links between hyoid movement and penetration–aspiration. The aims of this study were (a) to explore associations between hyoid parameters, laryngeal vestibule closure (LVC) parameters, and penetration–aspiration on thin liquids; and (b) to determine which of these parameters are the strongest predictors of penetration–aspiration.

Method:
This study involved retrospective analysis of an existing videofluoroscopy data set, collected in 305 participants (152 males) with noncongenital/nonsurgical/non-oncological risk for dysphagia. We extracted data for six thin liquid swallows per participant, and obtained measures of hyoid movement (peak position, speed) and LVC (complete/incomplete, timing, duration). Resulting values were coded as typical/atypical relative to healthy reference data. Relationships were explored using chi-square tests and odds ratios (a) for the entire data set and (b) for the subset of data with complete LVC. Hierarchical logistic regression models determined the strongest predictors of penetration–aspiration.

Results:
Significant associations were found between penetration–aspiration and incomplete LVC, prolonged time-to-most-complete-LVC, short LVC duration, reduced anterior hyoid peak position, and reduced hyoid speed. Hyoid measures were also significantly associated with LVC parameters. In the first regression model, incomplete LVC and prolonged time-to-most-complete-LVC were the only significant predictors of penetration–aspiration. For cases with complete LVC, the only significant predictor was prolonged time-to-most-complete-LVC.

Conclusions:
Although reduced anterior hyoid peak position and speed are associated with penetration–aspiration on thin liquids, these measures do not independently account for penetration–aspiration when considered in conjunction with measures of LVC. When identifying mechanisms explaining penetration–aspiration, clinicians should focus on LVC (complete/incomplete) and timeliness of LVC.
AMICO galaxy clusters in KiDS-DR3: Cosmological constraints from counts and stacked weak lensing
Authors: Lesci G. F. , Marulli F. , Moscardini L. , Sereno M. , Veropalumbo A. , Maturi M. , Giocoli C. , Radovich M. , Bellagamba F. , Roncarelli M. , Bardelli S. , Contarini S. , Covone G. , Ingoglia L. , Nanni L. , Puddu E. 
Published: January 2022

Aims.We present a cosmological analysis of abundances and stacked weak lensing profiles of galaxy clusters, exploiting the AMICO KiDS-DR3 catalogue. The sample consists of 3652 galaxy clusters with intrinsic richnessλ* ≥ 20, over an effective area of 377 deg2, in the redshift rangez ∈ [0.1,  0.6].Methods.We quantified the purity and completeness of the sample through simulations. The statistical analysis has been performed by simultaneously modelling the co-moving number density of galaxy clusters and the scaling relation between the intrinsic richnesses and the cluster masses, assessed through stacked weak lensing profile modelling. The fluctuations of the matter background density, caused by super-survey modes, have been taken into account in the likelihood. Assuming a flat Λ cold dark matter (ΛCDM) model, we constrained Ωm,σ8,S8 ≡ σ8(Ωm/0.3)0.5, and the parameters of the mass-richness scaling relation.Results.We obtained Ωm = 0.24−0.04+0.03,σ8 = 0.86−0.07+0.07, andS8 = 0.78−0.04+0.04. The constraint onS8is consistent within 1σwith the results from WMAP and Planck. Furthermore, we got constraints on the cluster mass scaling relation in agreement with those obtained from a previous weak lensing only analysis.
Past and present dynamics of the circumbinary moons in the Pluto-Charon system
Authors: Giuppone Cristian A. , Rodríguez Adrián , Michtchenko Tatiana A. , de Almeida Amaury A. 
Published: January 2022

Context. The Pluto-Charon (PC) pair is usually thought of as a binary in a dual synchronous state, which is the endpoint of its tidal evolution. The discovery of the small circumbinary moons, Styx, Nix, Kerberos, and Hydra, placed close to the mean motion resonances (MMRs) 3/1, 4/1, 5/1, and 6/1 with Charon, respectively, reveals a complex dynamical system architecture. Several formation mechanisms for the PC system have been proposed.
Aims. Assuming the hypothesis of an in situ formation of the moons, our goal is to analyse the past and current orbital dynamics of the satellite system. We plan to elucidate on in which scenario the small moons can survive a rapid tidal expansion of the PC binary.
Methods. We study the past and current dynamics of the PC system through a large set of numerical integrations of the exact equations of motion, accounting for the gravitational interactions of the PC binary with the small moons and the tidal evolution, modelled by the constant time lag approach. We construct stability maps in a pseudo-Jacobian coordinate system. In addition, considering a more realistic model that accounts for the zonal harmonic, J2, of Pluto’s oblateness and the ad hoc accreting mass of Charon, we investigate the tidal evolution of the whole system.
Results. Our results show that, in the chosen reference frame, the current orbits of all satellites are nearly circular, nearly planar, and nearly resonant with Charon, which can be seen as an indicator of the convergent dissipative migration experienced by the system in the past. We verify that, under the assumption that Charon completes its formation during the tidal expansion, the moons can safely cross the main MMRs without their motions being strongly excited and consequently ejected.
Conclusions. In the more realistic scenario proposed here, the small moons survive the tidal expansion of the PC binary without the hypothesis of resonant transport having to be invoked. Our results indicate that the possibility of finding additional small moons in the PC system cannot be ruled out.
The dynamics and observability of circularly polarized kink waves
Authors: Magyar N. , Duckenfield T. , Van Doorsselaere T. , Nakariakov V. M. 
Published: January 2022

Context. Kink waves are routinely observed in coronal loops. Resonant absorption is a well-accepted mechanism that extracts energy from kink waves. Nonlinear kink waves are know to be affected by the Kelvin-Helmholtz instability. However, all previous numerical studies consider linearly polarized kink waves.
Aims. We study the properties of circularly polarized kink waves on straight plasma cylinders, for both standing and propagating waves, and we compare them to the properties of linearly polarized kink waves.
Methods. We used the code MPI-AMRVAC to solve the full 3D magnetohydrodynamic equations for a straight magnetic cylinder, excited by both standing and propagating circularly polarized kink (m = 1) modes.
Results. The damping due to resonant absorption is independent of the polarization state. The morphology or appearance of the induced resonant flow is different for the two polarizations; however, there are essentially no differences in the forward-modeled Doppler signals. For nonlinear oscillations, the growth rate of small scales is determined by the total energy of the oscillation rather than the perturbation amplitude. We discuss possible implications and seismological relevance.
Evaluation of patient outcomes after operative treatment of intra-articular calcaneus fractures
Authors: Steelman Kevin , Bolz Nicholas , Feria-Arias Enrique , Meehan Robert 
Published: January 2022

Background: Percutaneous reduction with fixation and open reduction internal fixation are often used to treat intra-articular calcaneus fractures with no consensus on the preferred method. Open techniques have been associated with an increased risk of wound complications, while percutaneous techniques may result in inferior reduction capabilities. These injuries pose a challenge to patients as they often result in poor patient outcomes. We retrospectively analyzed patient outcomes of a single surgeon’s experience in treating these injuries at a busy urban Level 1 trauma center. Methods: Patients with intra-articular calcaneus fractures managed operatively over 10 years with a minimum six-month follow-up were included. Patients were divided into two cohorts based on operative technique: closed reduction and percutaneous fixation (CRPF) or open reduction internal fixation (ORIF). Descriptive analysis of each cohort included postoperative infection, the need for repeat operations, development of post-traumatic subtalar arthritis, and reduction capabilities as assessed by Bohler’s angle. Results: Sixty-two patients were included in this study, with 33 patients in the CRPF group and 29 patients in the ORIF group. Infection requiring a return to the operating room occurred in 1 (3%) CRPF and 7 (24%) ORIF patients. Instrumentation was removed in 23 (70%) CRPF and 9 (31%) ORIF patients. Clinical subtalar arthritis developed in 10 (30%) CRPF and 7 (24%) ORIF patients, requiring arthrodesis in 2 (6%) and 5 (17%) patients, respectively. Both techniques had acceptable restoration of Bohler’s angle immediately postoperatively and at final follow-up. Conclusions: Percutaneous reduction with fixation and open reduction internal fixation may both be considered for the surgical treatment of intra-articular calcaneal fractures. Indications for each technique may vary between surgeons, and each has its own set of risk factors and complications, however, both have been shown to result in an acceptable reduction. Level of Evidence: Level IV.
Tests zur Beurteilung der Bewegungsqualität nach ligamentären Verletzungen des Kniegelenks: eine systematische Übersichtsarbeit
Authors: Keller Matthias , Diemer Frank , Kurz Eduard 
Published: January 2022

ZusammenfassungHintergrund Rupturen der kapsuloligamentären Strukturen dominieren die Verletzungsstatistik am Kniegelenk. Die Beurteilung posttraumatischer Defizite oder Dysfunktionen bei dynamischen Bewegungsmustern erfolgt sowohl quantitativ als auch qualitativ. Ziel dieser Übersichtsarbeit war es, Werkzeuge, die zur Bewertung der Bewegungsqualität nach einer Kniebandverletzung bei Erwachsenen eingesetzt werden, zusammenzutragen.Methode In folgenden Primärquellen wurde eine systematische Suche nach Originalarbeiten durchgeführt: Ovid, PubMed, Scopus, Web of Science. Sowohl die konservativen als auch die operativen Therapieoptionen wurden berücksichtigt. PROSPERO Registrierung des Studienprotokolls: CRD42020175359.Ergebnisse Insgesamt wurden 1153 Arbeiten identifiziert. In diese Arbeit wurden 11 Originalarbeiten aus 4 verschiedenen Arbeitsgruppen eingeschlossen. In allen Arbeiten wurde die Bewegungsqualität bei Erwachsenen nach einer Ruptur des vorderen Kreuzbandes beurteilt. Insgesamt wurden in den eingeschlossenen Studien 348 (70 nicht operiert, 278 rekonstruiert) Patienten nach einer Verletzung des vorderen Kreuzbandes und 119 Erwachsene mit intaktem vorderem Kreuzband untersucht.Schlussfolgerung In der Praxis ist es möglich, die Bewegungsqualität nach einer Kniebandverletzung mit geringem zeitlichem und technischem Aufwand zu erfassen. Die erfassten Veränderungen resultieren in einem funktionellen Valgus, dessen Ausmaß basierend auf den Ergebnissen der einzelnen Arbeiten in einen isolierten Knievalgus, in einen medialen Kollaps oder einen posturalen Kollaps weiter differenziert werden kann.
Novel Insight into the Mechanism of Metabolic Surgery Causing the
Diversity in Glycemic Status in Type 2 Diabetes
Authors: Zhou Mengxiao , Wang Lijuan , Zhou Lujin , Chang Xiaotong , Zhu Xiaobo 
Published: January 2022

AbstractMetabolic surgery results in diverse glycemic status in patients with type 2
diabetes (T2D), including hyperglycemia without remission, significant
amelioration of hyperglycemia with partial remission, complete restoration of
euglycemia, or with prolonged remission, hyperglycemia recurrence in relapses
after remission, or post-bariatric hypoglycemia. Unfortunately, it is not known
how metabolic surgery leads to this diverse consequence. Here, we discuss the
diversity of glycemic status associated with metabolic surgery and the potential
mechanisms of T2D remission. We also highlight the relationship between the
change in low-grade inflammation and T2D remission after metabolic surgery. We
hypothesize that the level of inflammatory and anti-inflammatory cytokines
controls the efficacy of metabolic surgery in patients with T2D. This hypothesis
may provide further insight into the mechanism of the beneficial effects of
metabolic surgery patients with T2D.
Mimicking Enzymes: Taking Advantage of the Substrate-Recognition Properties of Metalloporphyrins in Supramolecular Catalysis
Authors: Gramage-Doria Rafael , Abuhafez Naba , Perennes Antoine 
Published: January 2022

AbstractThe present review describes the most relevant advances dealing with supramolecular catalysis in which metalloporphyrins are employed as substrate-recognition sites in the second coordination sphere of the catalyst. The kinetically labile interaction between metallo­porphyrins (typically, those derived from zinc) and nitrogen- or oxygen-containing substrates is energetically comparable to the non-covalent interactions (i.e., hydrogen bonding) found in enzymes enabling substrate preorganization. Much inspired from host–guest phenomena, the catalytic systems described in this account display unique activities, selectivities and action modes that are difficult to reach by applying purely covalent strategies.
Transition-Metal-Catalyzed Enantioselective Synthesis of Indoles from 2-Alkynylanilines
Authors: Ye Zhi-Shi , Li Jin-Chen , Wang Gang 
Published: January 2022

AbstractOptically active indole derivatives are ubiquitous in natural products and are widely recognized as privileged components in pharmacologically relevant compounds. Therefore, developing catalytic asymmetric approaches for constructing indole derivatives is highly desirable. In this short review, we summarize methods for the transition-metal-catalyzed enantioselective synthesis of indoles from 2-alkynyl­anilines.1	Introduction2	Aminometalation-Triggered Asymmetric Cross-Coupling Reactions/Insertion2.1	Asymmetric Cross-Coupling Reactions2.2	Asymmetric Insertion of C=O, C=C and C≡N Bonds3	Asymmetric Relay Catalysis4	Conclusion
Enantioselective C–H Functionalization toward Silicon-Stereogenic Silanes
Authors: He Chuan , Yuan Wei 
Published: January 2022

AbstractIn recent years, transition-metal-catalyzed enantioselective C–H bond functionalization has emerged as a powerful and attractive synthetic approach to access silicon-stereogenic centers, which provides impetus for the innovation of chiral organosilicon chemistry. This short review summarizes recent advances in the construction of silicon-stereogenic silanes via transition-metal-catalyzed enantioselective C–H functionalization. We endeavor to highlight the great potential of this methodology and hope that this review will shed light on new perspectives and inspire further research in this emerging area.1	Introduction2	Enantioselective C–H Functionalization Induced by Oxidative Addition­ of an Aryl-OTf Bond3	Enantioselective C–H Functionalization Induced by Oxidative Addition­ of a Silacyclobutane4	Directing-Group-Assisted Enantioselective C–H Functionalization5	Enantioselective Dehydrogenative C–H/Si–H Coupling5.1	Enantioselective C(sp2)–H Silylation5.2	Enantioselective C(sp3)–H Silylation6	Summary and Outlook
Tuning StackPhim Ligands: Applications in Enantioselective Borylation and Alkynylation
Authors: Aponick Aaron , Dahiya Gaurav , Abboud Khalil A. 
Published: January 2022

AbstractHere we present a new stack ligand with a modified imidazoline backbone prepared from cyclohexanediamine. This new stack ligand­, Cy-StackPhim, has been found to complement the parent StackPhim ligand in an enantioselective borylation reaction. Additionally, a correlation between the nature of substituents on the imidazoline ring and the substituents on the electrophile is also discussed.