bluuebunny/crossref_metadata_2025_split huggingface dataset:
How human–computer interaction perception affects consumer well-being in the context of online retail: from the perspective of autonomy
Authors: Shen Pengyi , Wan Demin , Li Jinxiong 
Published: June 2022

PurposeIn recent years, the application of artificial intelligence and digital technology has increasingly become a priority for online retailers. It is crucial to choose a way to make use of human–computer interaction (HCI) design to exert the positive influence of intelligent technology on consumer welfare. Despite the increasing use of HCI design in online retail context, there remain limitations in their effect of consumer well-being improvement. Although there is extensive literature in the field of consumer well-being improvement, few studies have empirically examined how HCI design drives the improvement of consumer well-being in the online retail context. Therefor, this study aims to deeply and systematically analyze the psychological mechanism between HCI and consumer well-being in the online retail environment.Design/methodology/approachThe empirical analysis is based on data collection of 476 samples of online shoppers through the online survey method. From the perspective of autonomy, this study deeply analyzes the influence mechanism of different dimensions of HCI perception on consumer well-being.FindingsThe results indicated that autonomy plays a positive intermediary role in the impact of perceived connectivity, perceived personalization, perceived control and perceived responsiveness on the eudaimonia and hedonic enjoyment. Also, it revealed that psychological resistance negatively regulates the impact of perceived connectivity, perceived personalization and perceived control on autonomy, while experience purchase positively regulates the impact of autonomy on hedonic enjoyment.Originality/valueThis paper expands the research situation of consumer well-being by making integration of the dual structure of subjective well-being and psychological well-being to define the psychological mechanism and boundary conditions of the impact of HCI perception on consumer well-being. The main contribution of this study is to provide enlightenment for online retail enterprises to improve HCI design and help consumers enhance long-term well-being.
Designing an optimal neural network architecture: an application to property valuation
Authors: Lee Changro 
Published: June 2022

PurposeThe success of a neural network depends on, among others, an architecture that is appropriate for the task at hand. This study attempts to identify an optimal architecture of a neural network in the context of property valuation, and aims to test the ability of connecting related neural networks to reduce the property valuation error.Design/methodology/approachThis study explores efficient network architectures to estimate land and house prices in Seoul, South Korea. The input is structured data, and the embedding technique is used to process high-cardinality categorical variables.FindingsThe shared architecture of a network for simultaneous estimation of both land and houses was revealed to be the best performing network. Through weight sharing between relevant layers in networks, the root-mean-square error (RMSE) for land price estimation was reduced significantly, from 0.55–0.68 using the baseline architecture, to 0.44–0.47 using the shared architecture.Originality/valueThe study results are expected to encourage active investigation of efficient architectures by using domain knowledge, and to promote interest in using structured data, which is still the dominant type in most industries.
Constructing CSR student self-consciousness through university social responsibility implementation: evidence in Indonesia
Authors: Agustina Lidya , Meyliana Meyliana , Hanny Hanny 
Published: June 2022

Purpose
The role of higher education institutions is paramount in creating social and cultural conditions for sustainability. Several studies show universities play an important role in promoting public understanding and awareness about sustainability. The purpose of this study is to analyze the application of university social responsibility (USR) on green and nongreen campuses and how it affects the corporate social responsibility (CSR) of students' self-consciousness (SSC), especially in accounting undergraduate programs by looking at how the undergraduate programs shape their curriculum and can build student awareness related to CSR.

Design/methodology/approach
A total of 704 accounting undergraduate programs students from eight different universities in Indonesia were surveyed to test the CSR SSC. Eight participating universities were included in the green campus based on Universitas Indonesia Green Metric (UI GreenMetric) and nongreen campus. Each university was analyzed regarding the application of USR.

Findings
The results of this study show that universities included in the green campus at the UI GreenMetric do not necessarily have a higher USR than the nongreen campus. Overall, there is evidence that graduates from universities with high USR implementation have better CSR SSC than graduates from universities with low USR implementation. Furthermore, the findings of this study show that there is a high value of ethic and CSR knowledge coming from university students with high USR implementation but not so with character. The findings show the same results from students between the two university groups.

Originality/value
To the best of the authors’ knowledge, this study is the first attempt to examine the effect of USR implementation on CSR SSC in Indonesia, by putting students’ CSR knowledge as a part of CSR SSC.
Applicability of healthcare service quality models and dimensions: future research directions
Authors: Ali Javed , Jusoh Ahmad , Idris Norhalimah , Nor Khalil Md , Wan Yulin , Abbas Alhamzah F. , Alsharif Ahmed H. 
Published: June 2022

PurposeThe purpose of this study is to explore the literature of healthcare service quality for identifying and analyzing the healthcare service quality models and dimensions and to present future research insights pertaining to the applications of these models and dimensions.Design/methodology/approachA literature review of healthcare service quality has been performed on 59 relevant studies after applying inclusion and exclusion criteria. Google Scholar and Scopus are the primary sources to find the relevant documents. Search was limited to keywords of “service quality,” “healthcare,” “models” and “dimensions.”FindingsThe results revealed that different models and dimensions have been evolved and developed after SERVQUAL in healthcare service quality literature. There is still a need to develop new models, add new contextual dimensions and items in existing models on different aspects of healthcare services. There is also a need to incorporate the perspective of service providers as respondents. Moreover, healthcare service quality models can be devolved or narrowed down at department and individual levels.Originality/valueThis study presents valuable research insights for the researchers and practitioners in ways that healthcare service quality models and dimensions can be developed, modified and tested further in different research contexts and settings. Besides, the literature on healthcare services can be enhanced and enriched.
4BNT162b2 mRNA COVID‐19 vaccine and semen: What do we know?
Authors: Olana Soraya , Mazzilli Rossella , Salerno Gerardo , Zamponi Virginia , Tarsitano Maria Grazia , Simmaco Maurizio , Paoli Donatella , Faggiano Antongiulio 
Published: June 2022

ABSTRACTBackgroundThe effects of an mRNA COVID‐19 vaccine on spermatozoa parameters are not known. The aim of this study was to evaluate the effect of the BNT162b2 mRNA COVID‐19 vaccine on human semen, comparing spermatozoa parameters before and after vaccine inoculation.Materials and methodsIn this single‐center prospective study, voluntary subjects who received mRNA vaccines from February to July 2021 were enrolled. The study population included male subjects aged between 18 and 45 years who completed the BNT162b2 mRNA COVID‐19 vaccine cycle. All subjects were evaluated before the first dose of vaccine (T0) and after 3 months (T1) with semen analysis and further analysis of seminal plasma, including colorimetric determination of reactive oxygen metabolites (d‐ROM test), electrolytes, and interleukin 6 (IL‐6) assessment by enzyme‐linked immunosorbent assay technology.ResultsThe experimental sample included 47 subjects (age: 29.3 ± 6.0 years, range 24–32; body mass index: 23.15 ± 2.5 kg/m2, range 19.2–28.0). All the subjects reported no systemic side effects. No significant differences were observed in any spermatozoa parameter between T0 and T1. A subanalysis was performed in oligoazoospermic and asthenozoospermic subjects, confirming the same results. Electrolyte analysis also showed no significant differences before and after vaccine inoculation. Finally, no significant differences were observed in T0, compared to T1 for the d‐ROM test and IL‐6.Discussion and conclusionIn this study, no significant differences in spermatozoa parameters before and after vaccine inoculations were found. Furthermore, oxidative stress analysis,, the activity of the cell membrane, and IL‐6, as a marker of inflammation, was not affected by the mRNA COVID‐19 vaccine. These results suggest that this vaccine is safe for male semen quality.
Prediction of ocular magnification and aniseikonia after cataract surgery
Authors: Langenbucher Achim , Szentmáry Nóra , Cayless Alan , Wendelstein Jascha , Hoffmann Peter 
Published: June 2022

AbstractBackgroundOcular magnification and aniseikonia after cataract surgery has been widely ignored in modern cataract surgery. The purpose of this study was to analyse ocular magnification and inter‐individual differences in a normal cataract population with a focus on monovision.MethodsFrom a large dataset containing biometric measurements (IOLMaster 700) of both eyes of 9734 patients prior to cataract surgery, eyes were indexed randomly as primary (P) and secondary (S). Intraocular lens power (IOLP) was derived for the HofferQ, Haigis and Castrop formulae for emmetropia for P and emmetropia or myopia (−0.5 to −2 dpt) for S to simulate monovision. Based on the pseudophakic eye model in addition to these formulae, ocular magnification was extracted using matrix algebra (refraction and translation matrices and a system matrix describing the optical property of the entire spectacle corrected or uncorrected eye).ResultsWith emmetropia for P and S the IOLP differences (S‐P) showed a standard deviation of 0.162/0.156/0.157 dpt and ocular magnification differences yielded a standard deviation of 0.0414/0.0405/0.0408 mm/mrad for the HofferQ/Haigis/Castrop setting. Simulating monovision, the myopic eye (S) showed a systematically smaller mean absolute spectacle corrected ocular magnification than the emmetropic eye (−0.0351/−0.0340/−0.0336, respectively, relative magnification around 2%). If myopia in the S eye remains uncorrected, the reduction of ocular magnification is much smaller (around 0.2–0.3%).ConclusionVergence formulae for IOLP calculation sometimes implicitly define a pseudophakic eye model which can be directly used to predict ocular magnification after cataract surgery. Despite a strong similarity of both eyes, ocular magnification does not fully match between eyes and the prediction of ocular magnification and aniseikonia might be relevant to avoid eikonic problems in the pseudophakic eye.
Initiation and duration of skin‐to‐skin contact for extremely and very preterm infants: A register study
Authors: Linnér Agnes , Lilliesköld Siri , Jonas Wibke , Skiöld Béatrice 
Published: June 2022

AbstractAimThis study sought to describe how skin‐to‐skin contact between extremely and very preterm infants and their parents is practised in Swedish neonatal units.MethodsData from the Swedish Neonatal Quality Register from 2020 to 2021 were extracted to analyse initiation time and daily duration of skin‐to‐skin contact in different gestational ages and regions.ResultsOf the 1475 infants in the cohort, mean (range) gestational age was 28 weeks (22–31), and mean (range) birthweight was 1205 g (360–2810). For extremely preterm infants (<28 weeks), median (interquartile range) skin‐to‐skin contact initiation time was at 88 postnatal hours (48–156) and 5% had skin‐to‐skin contact on the first day. For very preterm infants (<32 weeks), the corresponding numbers were 14 h (4–36) and 34%. Median (interquartile range) daily skin‐to‐skin contact duration for the entire cohort during the first day, first three and seven days and the remaining hospital stay was 0 (0–0), 0.7 (0–2.7), 1.6 (0.4–3.6) and 4.4 (3.0–6.1) h, respectively.ConclusionA minority of extremely and very preterm infants were exposed to skin‐to‐skin contact on the first postnatal day. Daily duration during the first week of life amounted to less than two hours. Initiation time and daily duration varied among gestational ages.
Psychometric properties of the ScreenQ for measuring digital media use in Portuguese young children
Authors: Monteiro Rita , Fernandes Sandra , Hutton John S. , Huang Guixia , Ittenbach Richard F. , Rocha Nuno Barbosa 
Published: June 2022

AbstractAimDigital media use is prevalent among children and linked to potential developmental and health risks, but validated measures of children's digital media use are lacking. The aim of this study was to validate the Portuguese version of the ScreenQ with three distinct children's age groups.MethodsParents of children living in Portugal completed an online survey including the 16‐item version of the ScreenQ and items related to home activities and digital media use. A combination of classical and modern theory (Rasch) methods was used for analysis.ResultsA total of 549 mothers and 51 fathers of 325 girls and 322 boys from 6 months to 9 years and 11 months old responded to the survey. Point‐measure correlations were all positive and endorsement of item values were within acceptable ranges. Cronbach's coefficient α was acceptable for a new measure, and test–retest reliability was high. Statistically significant correlations were found between ScreenQ total scores and relevant demographic, play‐related, parenting and digital media use items.ConclusionThe Portuguese version of the ScreenQ exhibited sound psychometric properties, including internal consistency and concurrent validity referenced to external items. Higher ScreenQ scores were correlated with higher digital media multitasking, lower parent–child interaction, and higher concerns regarding child's learning and behaviour.
SREBF2–STARD4 axis confers sorafenib resistance in hepatocellular carcinoma by regulating mitochondrial cholesterol homeostasis
Authors: Yue Xuetian , Kong Youzi , Zhang Yankun , Sun Min , Liu Shuyue , Wu Zhuanchang , Gao Lifen , Liang Xiaohong , Ma Chunhong 
Published: June 2022

AbstractSorafenib resistance limits its survival benefit for treatment of hepatocellular carcinoma (HCC). Cholesterol metabolism is dysregulated in HCC, and its role in sorafenib resistance of HCC has not been fully elucidated. Aiming to elucidate this, in vitro and in vivo sorafenib resistant models were established. Sterol regulatory element binding transcription factor 2 (SREBF2), the key regulator of cholesterol metabolism, was activated in sorafenib resistant HepG2 and Huh7 cells. Knockdown of SREBF2 resensitized sorafenib resistant cells and xenografts tumors to sorafenib. Further study showed that SREBF2 positively correlated with StAR related lipid transfer domain containing 4 (STARD4) in our sorafenib resistant models and publicly available datasets. STARD4, mediating cholesterol trafficking, not only promoted proliferation and migration of HepG2 and Huh7 cells, but also increased sorafenib resistance in liver cancer. Mechanically, SREBF2 promoted expression of STARD4 by directly binding to its promoter region, leading to increased mitochondrial cholesterol levels and inhibition of mitochondrial cytochrome c release. Importantly, knockdown of SREBF2 or STARD4 decreased mitochondrial cholesterol levels and increased mitochondrial cytochrome c release, respectively. Moreover, overexpression of STARD4 reversed the effect of SREBF2 knockdown on mitochondrial cytochrome c release and sorafenib resistance. In conclusion, SREBF2 promotes STARD4 transcription, which in turn contributes to mitochondrial cholesterol transport and sorafenib resistance in HCC. Therefore, targeting the SREBF2–STARD4 axis would be beneficial to a subset of HCC patients with sorafenib resistance.
High abundance of CDC45 inhibits cell proliferation through elevation of HSPA6
Authors: Fu Yuanyuan , Lv Zhiyi , Kong Deqing , Fan Yuping , Dong Bo 
Published: June 2022

AbstractObjectivesCDC45 is the core component of CMG (CDC45‐MCMs‐GINS) complex that plays important role in the initial step of DNA replication in eukaryotic cells. The expression level of cdc45 is under the critical control for the accurate cell cycle progression. Loss‐of‐function of cdc45 has been demonstrated to inhibit cell proliferation and leads to cell death due to the inhibition of DNA replication and G1‐phase arrest. An increasing of CDC45 inhibits cell proliferation as well. Nevertheless, a systematic analysis of the effect of high dose of CDC45 on cell physiology and behaviors is unclear. In the present study, we aimed to investigate the effects and mechanisms of high dose of CDC45 on cell behaviors.Materials and MethodsWe overexpressed cdc45 in cultured cell lines, Ciona and Drosophila embryos, respectively. The cell cycle progression was examined by the BrdU incorporation experiment, flow cytometry and PH3 (phospho‐Histone 3) staining. RNA‐sequencing analysis and qRT‐PCR were carried out to screen the affected genes in HeLa cells overexpressing cdc45. siRNA‐mediated knockdown was performed to investigate gene functions in HeLa cells overexpressing cdc45.ResultsWe found that high level of cdc45 from different species (human, mammal, ascidian, and Drosophila) inhibited cell cycle in vitro and in vivo. High dose of CDC45 blocks cells entering into S phase. However, we failed to detect DNA damage and cell apoptosis. We identified hspa6 was the most upregulated gene in HeLa cells overexpressing cdc45 via RNA‐seq analysis and qRT‐PCR validation. Overexpression of Hs‐hspa6 inhibited proliferation rate and DNA replication in HeLa cells, mimicking the phenotype of cdc45 overexpression. RNAi against hspa6 partially rescued the cell proliferation defect caused by high dose of CDC45.ConclusionsOur study suggests that high abundance of CDC45 stops cell cycle. Instead of inducing apoptosis, excessive CDC45 prevents cell entering S phase probably due to promoting hspa6 expression.
Efficacy and safety of a basal insulin + 2‐3 oral antihyperglycaemic drugs regimen versus a twice‐daily premixed insulin + metformin regimen after short‐term intensive insulin therapy in individuals with type 2 diabetes: The multicentre, open‐label, randomized controlled BEYOND‐V trial
Authors: Pan Qi , Li Yijun , Wan Hailong , Wang Junfen , Xu Binhua , Wang Guoping , Jiang Chengxia , Liang Li , Feng Wei , Liu Jingcheng , Wang Ting , Zhang Xia , Cui Nan , Mu Yiming , Guo Lixin ,   for the BEYOND V Study Investigators
Published: June 2022

AbstractAimTo compare the efficacy and safety of basal insulin glargine 100 units/ml (Gla) + 2‐3 oral antihyperglycaemic drugs (OADs) with twice‐daily premixed insulin aspart 70/30 (Asp30) + metformin (MET) after short‐term intensive insulin therapy in adults with type 2 diabetes in China.Materials and MethodsThis open‐label trial enrolled insulin‐naïve adults with type 2 diabetes and an HbA1c of 7.5%‐11.0% (58‐97 mmol/mol) despite treatment with 2‐3 OADs. All participants stopped previous OADs except MET, then received short‐term intensive insulin therapy during the run‐in period, when those with a fasting plasma glucose of less than 7.0 mmol/L and 2‐hour postprandial glucose of less than 10.0 mmol/L were randomized to Gla + MET + a dipeptidyl peptidase‐4 inhibitor or twice‐daily Asp30 + MET. If HbA1c was more than 7.0% (>53 mmol/mol) at week 12, participants in the Gla group were added repaglinide or acarbose, at the physician's discretion, and participants in the Asp30 group continued to titrate insulin dose. The change in HbA1c from baseline to week 24 was assessed in the per protocol (PP) population (primary endpoint).ResultsThere were 384 enrollees (192 each to Gla and Asp30); 367 were included in the PP analysis. The threshold for non‐inferiority of Gla + OADs versus Asp30 + MET was met, with a least squares mean change from baseline in HbA1c of –1.72% and –1.70% (–42.2 and –42.1 mmol/mol), respectively (estimated difference –0.01%; 95% CI –0.20%, 0.17% [–0.1 mmol/mol; 95% CI –2.2, 1.9]). Achievement of HbA1c less than 7.0% (<53 mmol/mol) was comparable between the groups (60% vs. 57%). The proportion of participants with any (24% vs. 38%; P = .003), symptomatic (19% vs. 31%; P = .007) or confirmed hypoglycaemia (18% vs. 33%; P < .001) was lower in the Gla + OADs group.ConclusionsCompared with Asp30 + MET, Gla + 2‐3 OADs showed similar efficacy but a lower hypoglycaemia risk in Chinese individuals with type 2 diabetes who had undergone short‐term intensive insulin therapy.
Identification of water flow through non‐root soil macropores and along roots in shrub‐encroached grassland
Authors: Hu Xia , Li Xiao‐Yan , Zhao Yun‐Duo , Cheng Ya‐Qian , Gao Zhou , Yang Zhi‐Guang 
Published: June 2022

AbstractIdentification of water flow through non‐root soil macropores and along roots using X‐ray computed tomography (CT) is still challenging because of limited methods to quantify roots and pore structures. This study selected shrub‐encroached grassland consisting of a mosaic of shrub patches and interspace grass patches and the original grassland as a control treatment. Twelve intact soil columns (0–30 cm deep) were excavated, which included four replicates each from the soils under the original grassland, the shrub patches and interspace grass patches. Three‐dimensional networks of soil macropores and roots were quantified using CT scanning and image analysis techniques, and active flow pathways were identified through KI tracing experiment using CT scanning. The results showed that the tracer depths of soils under the shrub patches and interspace grass patches were deeper than those of the original grassland, which was attributed to the well‐developed root system. The tracer volume density was significantly and positively correlated with soil macropore node density and root volume density (p < 0.05), and significantly and negatively correlated with root mean angle (p < 0.05). Soils under the shrub patches had lower tracer volume density than that under the interspace grass patches, which was attributed to the horizontal‐oriented roots under the shrub patches. The relative contribution of water flow along roots was larger than that through non‐root soil macropores 35 min after dye application. This provided direct evidence that shrub roots were the main pathway of macropore flow resulting in water flow into deep soil layers in the shrub‐encroached grassland.Highlights
The tracer depths of shrub‐encroached grassland were deep due to well‐developed root system.
Shrub patches had low tracer volume density due to the horizontal‐oriented roots.
The contribution of water flow along roots was larger than that through non‐root soil macropores.
Shrub roots were the main pathway of water flow.