bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curcuminoids can prevent post-contrast acute kidney injury in chronic kidney disease patients: A randomized controlled trial
Authors: Jaturapisanukul Solos , Kurathong Sathit , Ngamvichchukorn Tanun , Trakarnvanich Thananda 
Published: September 2022

Background:
Post contrast acute kidney injury (PC-AKI) following coronary procedures is a common cause of renal impairment in hospitalized patients, curcuminoids exert anti-inflammatory and antioxidant actions and have shown positive effects on renal hemodynamic protection The objective of this study was to evaluate the role of curcuminoids in the prevention of PC-AKI in chronic kidney disease (CKD) patients.

Methods:
This study was a single-center, prospective, double-blind, randomized, placebo-controlled trial in patients with CKD undergoing elective coronary angiography (CAG) at Vajira Hospital from October 2018 to March 2019. Patients were randomized to receive curcuminoids at 1500 mg per day 3 days before and 2 days after the procedure or placebo. The primary outcome was the development of PC-AKI, and the secondary outcomes were overall acute kidney injury (AKI) incidence within 7 days after CAG, changes in estimated glomerular filtration rate (eGFR), interleukin-6 (IL-6), high sensitivity C-reactive protein (hs-CRP), and other adverse events.

Results:
Sixty patients were enrolled in this study (30 in the curcuminoid group and 30 in the control group). AKI developed in 5 patients in the control group but not in the curcuminoid group (16.67% vs 0%, P = .052). that curcuminoids could preserve changes in eGFR compared to the placebo group (-1.5 vs 2.5 mL/min/1.73 m2, P value <.001 within 48 hours and -4 vs 1 mL/min/1.73 m2, P value 0.002 within 7 days). However, the hs-CRP and IL-6 levels did not differ between the groups. No serious adverse events were observed in either of the groups.

Conclusion:
Prophylactic administration of curcuminoids, in addition to standard treatment, reduces the incidence of PC-AKI in patients with CKD undergoing elective CAG.
Cholesterol crystal embolism in multiple organs after transarterial chemoembolization for hepatocellular carcinoma: An autopsy case report
Authors: Yamashita Junki , Nosaka Takuto , Takahashi Kazuto , Naito Tatsushi , Ofuji Kazuya , Matsuda Hidetaka , Ohtani Masahiro , Hiramatsu Katsushi , Kobayashi Motohiro , Nakamoto Yasunari 
Published: September 2022

Rationale:
Transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) rarely causes cholesterol crystal embolism (CCE). In our case, the histological findings suggested that the onset of CCE occurred at different time points in different organs.

Patient concerns:
A 72-year-old Japanese woman with HCC underwent TACE. After TACE, serum creatinine level and eosinophil count gradually increased. Three months later, she was admitted to our department with a fever and back pain.

Diagnosis:
Laboratory examinations showed sepsis with disseminated intravascular coagulation. She was treated with antimicrobial agents and anticoagulants, but died of multiple organ failure.

Interventions:
An autopsy was performed to examine the cause of multiple organ failure after 3 months of TACE.

Outcomes:
A mixture of both chronic phase emboli with intimal thickening and fibrosis and acute phase emboli with inflammatory cell infiltration were observed in the small intestine. Moreover, multiple intravascular cholesterol fissures were observed in the kidney, stomach, duodenum, colon, pancreas, and spleen, which were the vascular dominant organs of the celiac artery and superior mesenteric artery. These histological findings suggested that cholesterol crystals were continuously disseminated after TACE.

Lessons:
TACE for HCC may cause progressive CCE and damage in multiple organs. When progressive renal dysfunction, eosinophilia, or multiple organ dysfunction is observed after TACE, the CCE should be suspected.
BNT162b2 coronavirus disease-2019 vaccination accelerated rheumatoid arthritis disease activity in chronic eosinophilic pneumonia: A case report
Authors: Morikawa Moeko Murano , Harada Masanori , Kishimoto Ei , Suzuki Kosuke , Nakagawa Emiko , Hiramatsu Toshiya , Nakai Shogo , Murakami Yurina , Nishimoto Koji , Matsushima Sayomi , Uto Tomohiro , Imokawa Shiro 
Published: September 2022

Rationale:
The relationship between rheumatoid arthritis (RA) and eosinophilic inflammation is unclear. According to recent studies, it has been suggested that T helper 2 cell responses play a role in the inhibition of RA. It is unclear how the immunological response after coronavirus disease-2019 (COVID-19) vaccination affects T cell immune reactions.

Patient concerns and diagnoses:
Here, we report the case of an 88-year-old woman diagnosed with RA and chronic eosinophilic pneumonia (CEP). She was diagnosed with CEP about 20 years ago, and, through steroid treatment, she improved and had no relapse for 16 years. At the time of diagnosis of CEP, the rheumatoid factor (RF) was increased; however, there were no joint symptoms. After receiving the COVID-19 vaccine, joint and respiratory symptoms gradually worsened. Laboratory examinations showed increased RF, anti-cyclin citrullinated peptide antibody, and peripheral absolute eosinophil count. Musculoskeletal ultrasonography showed synovitis.

Intervention and outcome:
Methylprednisolone pulse therapy improved respiratory and joint symptoms immediately; RA and CEP stabilized with no relapses.

Lessons:
Eosinophilic and rheumatoid reactions following COVID-19 vaccination were an-reported adverse events. Eosinophilic inflammation might be reflected on an anti-inflammatory reaction in initial phase of RA.
Perirenal hematoma and delayed contrast metabolism after cerebral intravascular therapy: A case report
Authors: Li Yang , Zhao Xin , Zhang Ying , Yang Qian , Liu Guoxing , Liu Tao , Zhang Xuekai , Zhou Ming 
Published: September 2022

Rationale:
Hematomas after percutaneous angiography often occur in the thigh, retroperitoneal, intraperitoneal, or abdominal wall. Renal hematoma after percutaneous angiography is very rare.

Diagnoses:
Herein, we present a case of perirenal hematoma and delayed contrast metabolism after cerebral angiograph, which may be caused by improper operation.

Interventions:
Conservative treatments which development by multi-disciplinary collaboration.

Outcomes:
After treatment, the clinical symptoms of the patients gradually disappeared and the imaging results became negative.

Conclusion:
Though the patient missed timely diagnosis and treatment, fortunately no catastrophic events occurred. Meanwhile, the potential causes, diagnosis, and therapeutic management were all discussed.
Efficacy and safety of acupuncture in the treatment of the sequela of olfactory disorders after infection with COVID-19: A protocol for systematic review and meta analysis
Authors: Tang Chao , He Xiaoqin , Fu Wenkang , Du Yaxin , Huang Yuxin , Liu Lu , Lan Wanning , Luo Runjun , Liu Yue 
Published: September 2022

Background:
From the end of 2019 to now, coronavirus disease 2019 (COVID-19) has put enormous strain on the world’s health systems. As a characteristic sign of COVID-19 patient, olfactory dysfunction (OD) poses considerable problems for patients. In China, acupuncture has been widely used to treat OD caused by COVID-19, but there is still a lack of evidence-based medical evaluation. This study was designed to evaluate the effectiveness and safety of acupuncture for the treatment of COVID-19 OD.

Methods:
According to the retrieval strategies, randomized controlled trials on the acupuncture for COVID-19 OD were obtained from Cochrane Central Register of Controlled Trials, Embase, PubMed, Web of Science, the Chinese National Knowledge Infrastructure, the Chinese Biomedical Literature Database, the Chinese Scientific Journal Database and the Wanfang Database, regardless of publication date, or language. Studies were screened based on inclusion and exclusion criteria, and the Cochrane risk bias assessment tool was used to evaluate the quality of the studies. The meta-analysis was performed using Review Manager (RevMan 5.3) and STATA 14.2 software. Ultimately, the evidentiary grade for the results will be evaluated.

Results:
The results of this meta-analysis will be submitted to a peer-reviewed journal for publication.

Conclusion:
This study will provide up-to-date summary proof for evaluating the effectiveness and safety of acupuncture for COVID-19 OD.
Corneodesmosin as a potential target of oral squamous cell carcinoma
Authors: Di Yong-Bin , Bao Yang , Guo Jie , Liu Wei , Zhang Su-Xin , Zhang Guan-Hua , Li Tian-Ke 
Published: September 2022

Objective:
The relationship between oral squamous cell carcinoma (OSCC) and Corneodesmosin (CDSN) remains unclear. This study aims to explore the correlation between CDSN and the prognosis and survival time of patients with OSCC.

Methods:
Bioinformatics were used to identify the hub role of CDSN in the OSCC. A total of 200 patients with OSCC were recruited. Clinical and follow-up data were recorded, and the expression level of CDSN was detected. Pearson chi-square test and Spearman correlation coefficient were used to analyze the relationship between prognosis and related parameters in patients with OSCC. Univariate and multivariate Logistic regression and Cox proportional risk regression were applied for further analysis, and receiver operating characteristic curve and survival curve of subjects were plotted.

Results:
CDSN was identified as the most significant hub gene of the OSCC by the cytoHubba. By the comparative toxicogenomics database (CTD) analysis, there was strong relationship between the CDSN and mouth neoplasms, head and neck neoplasms, squamous cell carcinoma of head and neck. The OSCC patients with low expression level of CDSN have poor overall survival compared with the high expression level of CDSN (HR = 0.75, 95% confidence interval [95%CI]: 0.57-0.98, P = .036). Spearman correlation coefficient analysis showed that CDSN expression level was significantly correlated with prognosis (ρ = -0.528, P < .001). Multivariate Logistic regression analysis showed that poor prognosis (odds ratio [OR] = 0.096, 95%CI: 0.049-0.189, P < .001) was significantly associated with low expression of CDSN. Cox regression analysis showed that the survival time of OSCC patients was shorter when CDSN expression was low (HR = 0.588, 95%CI: 0.420-0.823, P = .002). Strong predictive value of CDSN for the OSCC survival time was obtained by the biological process (BP)-neural network and support vector machine (SVM).

Conclusion:
CDSN was significantly correlated with OSCC, and the shorter the survival time of patients with OSCC was, the worse the prognosis was.
Prognostic factors for overall survival after surgical resection in patients with thymic epithelial tumors: A systematic review and meta-analysis
Authors: Li Jiaduo , Liu Yaling , Zhang Xiaohe , Zheng Xuguang , Qi Guoyan 
Published: September 2022

Background:
Thymic epithelial tumors (TETs) originate in the thymic epithelial cell, including thymoma and thymic carcinoma. Surgical resection is the first choice for most patients. However, some studies have shown that the factors affecting the prognosis of these patients are not consistent. To evaluate prognostic factors in patients with surgically resected thymic epithelial tumors, we performed a meta-analysis.

Methods:
We searched the Chinese biomedical literature database, Pubmed, Embase, Cochrane Library and other electronic databases. Studies including postoperative overall survival (OS) and predictors of TETs were included. We made a comprehensive analysis the hazard ratios (HRs) through a single proportional combination. HRs were combined using single proportion combinations.

Results:
The meta-analysis included 11,695 patients from 26 studies. The pooled OS was 84% at 5 years and 73% at 10 years after TETs operation. The age as continuous-year (HR 1.04, 95% confidence interval (CI) 1.02–1.04), incomplete resection (HR 4.41, 95% CI 3.32–5.85), WHO histologic classification (B2/B3 vs A/AB/B1 HR 2.76, 95% CI 1.25–6.21), Masaoka Stage (stage III/IV vs I/II HR 2.74, 95% CI 2.12–3.55,) were the poor prognostic factors.

Conclusions:
For patients with TETs after surgical resection, advanced age, incomplete resection, WHO classification B2/B3, and higher Masaoka stage are risk factors for poor prognosis.
A meta-analysis of intravenous thrombolysis versus bridging therapy for ischemic stroke
Authors: Wang Raoqiong , Li Shuangyang , Hao Linyao , Wang Zhichuan , Ge Zhengxin , Yang Sijin 
Published: September 2022

Background:
The purpose of this study was to perform a pooled analysis of randomized controlled trials (RCT) of intravenous thrombolysis (IVT) versus bridging therapy of intravenous thrombolysis and mechanical thrombectomy (IVMT), comparing the efficacy and safety of the two in patients with acute ischemic stroke (AIS).

Methods:
All eligible RCT articles from database establishment to December 8, 2021 were searched in databases such as PubMed, Ovid, Embase, Web of science, Cochrane Library, etc. Efficacy outcomes were assessed by modified RANKIN scal (mRS) score, complete recanalization or reperfusion (TICI), National Institute of Health Stroke Scal (NIHSS) score, 90-day mortality, 24 to 36 h incidence of symptomatic intracranial hemorrhage (sICH).

Results:
Our study included 6 RCT involving 1717 patients. The proportion of the primary efficacy outcome (mRS score 0‐2 at 90 days) was significantly different between IVT and IVMT (OR 0.51; 95% CI 0.35‐0.76). For the secondary efficacy outcome, the study found a significant difference in the proportion of TICI (pooled OR was 0.055, 95% CI 0.07‐0.33). There was a significant difference in the 24 h NIHSS score between the IVT group and the IVMT group (pooled MD was 3.25, 95% CI 0.80‐5.70). There were no significant differences in the NIHSS score at 90 days, the death rate at 90 days, and the sICH at 24 to 36 hours between the two groups.

Conclusions:
This study confirms that IVMT is more effective and safe than IVT alone in patients with AIS. However, more and higher-quality randomized clinical trials comparing IVMT to IV alone are warranted for validation.
Effectiveness of a physical activity intervention on the overweight and obesity of Chilean schoolchildren
Authors: Godoy-Cumillaf Andrés , Fuentes-Merino Paola , Giakoni-Ramírez Frano , Duclos-Bastías Daniel , Merellano-Navarro Eugenio 
Published: September 2022

Introduction:
Physical fitness is considered a measure that integrates most of the functions of the human organism that are involved in physical activity. Motor competence is important due to its observed implications in the physical, mental and social development of children and adolescents. These assessments require the existence of updated reference values that allow the categorization of individuals and groups according to levels of physical fitness and motor competence. This paper describes the study protocol to Effectiveness of a Physical Activity Intervention on the Overweight and Obesity of Chilean Schoolchildren, and in this way determine, through the calculation of a representative sample, reference values for physical fitness and motor competence in children aged 4 to 6 years in the region of La Araucanía, Chile.

Methods:
children in pre-basic education in transition grades I and II (4 and 5 years old), and those in the first year of basic education (6 years old) will be invited to participate. The sample will be probabilistic. The measures of a randomized controlled trial (registered in ClinicalTrial.gov NCT04194580) will be used.

Conclusion:
the lack of reference values for physical condition and motor competence for children between 6 and 4 years of age in the Araucanía region highlights the need to establish values, which will contribute to improving the health of children of the age group to be worked on.
Magnet® Supporting Our Purpose
Authors: Pappas Sharon , Erickson Jeanette Ives 
Published: September 2022

ABSTRACT
The authors, Magnet® Commissioners, provide a reflection on their personal journeys in leading healthcare organizations where the role of nurses is valued by both the organization and those we serve. The authors believe that nurses, through the application of evidence-based leadership principles, are the cornerstone of passion and commitment to excellence in healthcare.
Evidence-based interventions to treat chronic low back pain: treatment selection for a personalized medicine approach
Authors: Mauck Matthew C. , Aylward Aileen F. , Barton Chloe E. , Birckhead Brandon , Carey Timothy , Dalton Diane M. , Fields Aaron J. , Fritz Julie , Hassett Afton L. , Hoffmeyer Anna , Jones Sara B. , McLean Samuel A. , Mehling Wolf E. , O'Neill Conor W. , Schneider Michael J. , Williams David A. , Zheng Patricia , Wasan Ajay D. 
Published: September 2022

Abstract

Introduction:
Chronic low back pain (cLBP) is highly prevalent in the United States and globally, resulting in functional impairment and lowered quality of life. While many treatments are available for cLBP, clinicians have little information about which specific treatment(s) will work best for individual patients or subgroups of patients. The Back Pain Research Consortium, part of the National Institutes of Health Helping to End Addiction Long-termSM (HEAL) Initiative, will conduct a collaborative clinical trial, which seeks to develop a personalized medicine algorithm to optimize patient and provider treatment selection for patients with cLBP.

Objective:
The primary objective of this article is to provide an update on evidence-based cLBP interventions and describe the process of reviewing and selecting interventions for inclusion in the clinical trial.

Methods:
A working group of cLBP experts reviewed and selected interventions for inclusion in the clinical trial. The primary evaluation measures were strength of evidence and magnitude of treatment effect. When available in the literature, duration of effect, onset time, carryover effect, multimodal efficacy, responder subgroups, and evidence for the mechanism of treatment effect or biomarkers were considered.

Conclusion:
The working group selected 4 leading, evidence-based treatments for cLBP to be tested in the clinical trial and for use in routine clinical treatment. These treatments include (1) duloxetine, (2) acceptance and commitment therapy, (3) a classification-based exercise and manual therapy intervention, and (4) a self-management approach. These interventions each had a moderate to high level of evidence to support a therapeutic effect and were from different therapeutic classes.
Extended Maxillary Osteotomy Guide: A Design That Allows Manipulation of the Osteotomy Direction on the Posterior and Inner Walls of the Maxilla
Authors: Wang Yuan-Yuan , Lin Yang-Yang , Qiao Tao , Duan Jing-Hao , Yang Yun-Qi , Hou Min 
Published: September 2022

Purpose:
Design an extended osteotomy guide (EOG) for Le Fort I osteotomy to improve the safety of surgery.

Materials and Methods:
The digital Le Fort I osteotomy guide was designed in MIMICS 23.0. Twenty-eight patients were randomized into 2 groups. Patients in the experimental group used EOG, and patients in the control group used a traditional osteotomy guide (TOG). Virtual designs and actual postoperative outcomes were compared by cone-beam computed tomography. The safety of the operation was confirmed by the accuracy of the osteotomy direction and depth on the inner and posterior walls of the maxilla.

Results:
All positioning deviations of both osteotomy guides were <0.3 mm (P>0.05). The osteotomy depths on the inner and posterior walls with the EOG and TOG deviated by 0.789±1.179 and 1.811±1.345 mm (P=0.004) and 0.648±0.999 and 1.262±0.942 mm (P=0.030), respectively. The angles of deviation of the osteotomy direction on the inner and posterior walls by the EOG and TOG were 2.025±2.434 and 5.069±2.391 degrees (P<0.001) and 2.772±2.979 and 8.653±4.690 degrees (P<0.001), respectively.

Conclusions:
The EOG was more accurate than TOG for manipulating osteotomy direction and depth on the inner and posterior maxillary walls. Thus, EOG could ensure higher surgical safety than TOG.
Maxillary Total Elongation Surgery using 3D Virtual Surgery, CAD/CAM and 3D Printing Technology: Surgical Convenience and Accuracy
Authors: Ha Sung-Ho , Maeng Ji Youn , Baek Seung-Hak , Choi Jin-Young 
Published: September 2022

After Le Fort I osteotomy was first performed by von Langernbeck in 1859, there has been many improvements since. Research on and development of Le Fort I osteotomy procedure has shown downward movement of the maxilla to exhibit lowest stability and accuracy. However, maxillary downgraft movement is necessary in orthognathic patients with insufficient vertical length of the maxilla, but fixation of the maxilla after elongation is often very inaccurate. In this study, the authors utilized 3D virtual surgery, CAD/CAM-assisted 3D printing technology to overcome such limitations of maxillary total elongation. In addition, accuracy at 7 different landmarks from superimposition of virtual simulation data and postoperative Cone-beam computed tomography (CBCT) data were measured. Although posterior maxilla exhibited bigger range of errors, an error of <1 mm was measured at all 7 landmarks. Operation time was greatly shortened with cutting guides and customized plates. Although this study is a single-case study, this study shows increased accuracy and efficacy from application of 3D virtual surgery, CAD/CAM, and 3D printing technology.
Development and Validation of a Symptom-based Scoring System for Bowel Dysfunction After Ileoanal Pouch Reconstruction
Authors: Cavallaro Paul , Bordeianou Liliana ,   on behalf of the PROPS Scientific Committee
Published: September 2022

Objective:
To utilize items identified as priorities by the Patient-Reported Outcomes after Pouch Surgery Delphi consensus study to create a validated tool for quantifying pouch function.

Background:
The Patient-Reported Outcomes After Pouch Surgery Delphi consensus study identified 7 symptoms and 7 consequences as key domains for evaluating and analyzing ileoanal pouch function.

Methods:
Pouch patients were recruited at inflammatory bowel disease centers and via patient advocacy websites. They were administered a questionnaire-based survey eliciting responses regarding the frequency of a variety of bowel symptoms. Associations between items and quality of life were computed in a score generation cohort of 298 patients by logistic regression modeling. Individual score values were designated to items to create an additive score titled the “Ileoanal Pouch Syndrome Severity Score.” Validity was tested in a subsequent cohort of 386 patients using receiver operating characteristic area under the curve. In addition, test–rest validity, convergent validity, and clinical validity were evaluated.

Results:
After the determination of item weights, the range of possible scores was 0 to 145. Score ranges were then determined as cutoff values for “ileoanal pouch syndrome.” The score was then validated on the second patient cohort, with a receiver operating characteristic area under the curve of 0.83. Importantly, worsening severity of Ileoanal Pouch Syndrome score significantly correlated with higher rates of poor quality of life. Lastly, the questionnaire was rigorously validated to show test–retest validity, convergent validity compared with other bowel function scores, and clinical validity.

Conclusions:
This study developed a patient-centered, clinically useful scoring system that can quantify the range and severity of symptoms experienced by ileoanal pouch patients and their correlation with quality of life.