bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-assembly of cellular neighborhoods converts stochastic signaling into sustained olfactory neurogenesis
Authors: Rajan Sriivatsan G. , Lombardo Joseph N. , Nacke Lynne M. , Manuchehrfar Farid , Wong Kaelan , Garcia Jocelyn , Liang Jie , Saxena Ankur 
Published: September 2022

SUMMARYOlfactory neurogenesis occurs continuously throughout the lives of vertebrates, including in humans, and relies on the rapid, unceasing differentiation and integration of neurons into a complex multicellular network. The system-wide regulation of this intricate choreography is poorly understood; in particular, it is unclear how progenitor cells convert stochastic fluctuations in cell-cell signaling, over both space and time, into streamlined fate decisions. Here, we track single-cell level multicellular dynamics in the developing zebrafish olfactory epithelium, perturb signaling pathways with temporal specificity, and find that the continuous generation of neurons is driven by the spatially-restricted self-assembly of transient groups of progenitor cells, i.e. cellular neighborhoods. Stochastic modeling and validation of the underlying genetic circuit reveals that neighborhood self-assembly is driven by a tightly regulated bistable toggle switch between Notch signaling and the transcription factor Insulinoma-associated 1a that is responsive to inter-organ retinoic acid signaling. Newly differentiating neurons emerge from neighborhoods and, in response to brain-derived neurotrophic factor signaling, migrate across the olfactory epithelium to take up residence as apically-located, mature sensory neurons. After developmental olfactory neurogenesis is complete, inducing injury results in a robust expansion of neighborhoods, followed by neuroregeneration. Taken together, these findings provide new insights into how stochastic signaling networks spatially pattern and regulate a delicate balance between progenitors and their neuronal derivatives to drive sustained neurogenesis during both development and regeneration.
Excitatory inhibitory imbalance underlies hippocampal atrophy in individuals with 22q11.2 Deletion Syndrome with psychotic symptoms
Authors: Mancini Valentina , Saleh Muhammad G. , Delavari Farnaz , Bagautdinova Joëlle , Eliez Stephan 
Published: September 2022

AbstractBackgroundAbnormal neurotransmitter levels have been reported in subjects at high risk for schizophrenia, leading to a shift in the excitatory/inhibitory balance. However, it is unclear if these alterations are predating the onset of clinically relevant symptoms. Our aim was to explore in vivo measures of excitatory/inhibitory balance in 22q11.2 deletion carriers, a population at high genetic risk for psychosis.MethodsGlx (glutamate + glutamine) and GABA+ concentrations were estimated in the anterior cingulate cortex (ACC), superior temporal gyrus (STG) and hippocampus using a MEGAPRESS sequence and the Gannet toolbox in 52 deletion carriers and 42 controls. T1-weighted images were acquired longitudinally and processed with Freesurfer v.6.0 to extract hippocampal volume. Subgroup analyses were conducted in deletion carriers with psychotic symptoms identified by means of SIPS.ResultsWhile no differences were found in the ACC, deletion carriers had higher levels of Glx in the hippocampus and STG, and lower levels of GABA+ in the hippocampus compared to controls. We additionally found a higher Glx concentration in the hippocampus of psychotic compared to non-psychotic deletion carriers. Finally, more pronounced hippocampal atrophy and increased functional variability were both significantly associated with increased Glx levels in deletion carriers.ConclusionsThis study provides evidence for an excitatory/inhibitory imbalance in temporal brain structures of deletion carriers, with a further hippocampal Glx increase in individuals with psychotic symptoms that was associated with hippocampal atrophy and abnormal function. These results support theories proposing abnormally enhanced glutamatergic neural transmission as a mechanistic explanation for hippocampal atrophy via excitotoxicity. Overall, our results highlight a central role of glutamate in the hippocampus of individuals at genetic risk for schizophrenia.
Mucosal immunity and antibody anergy in COVID-exposed Covishield vaccinees
Authors: Kannian Priya , Mahanathi Pasuvaraj , Gracemary Arul , Kumarasamy Nagalingeswaran , Challacombe Stephen J. 
Published: September 2022

AbstractKnowledge is limited on mucosal immunity induction and longitudinal responses to vaccination against SARS-CoV2. Here, we determined serum/salivary antibodies and cytokines after three Covishield vaccine doses. Sera from 205 healthcare workers (HCWs) one-month after first- dose; one-, three- and six-months after second-dose; paired sera and stimulated whole mouth fluid (SWMF) from 10 HCWs one-, three- and six-months after third-dose were tested for anti- spike SARS-CoV2 antibodies by ECLIA and for cytokines by ELISA/cytokine bead arrays. One-month after second-dose, antibodies had increased significantly (6-fold) in COVID-naïve group, but declined (1.5-fold) in those previously exposed to COVID. At one-month after first- dose, IL-10 levels were statistically higher in the previously COVID-exposed group compared to COVID-naïve group (p<0.02). Breakthrough infections were 44% in COVID-naïve group, while re-infections were 27% in COVID-exposed group (p<0.02). Proinflammatory cytokines–IL- 17/IL-21 at one-month after first- and second-doses, and memory cytokines–IL-7/IL-15 at three- and six-months after second-dose were minimal. Antibodies spiked at one-month after third- dose and declined by three- and six-months after third-dose similar to post-second-dose. Paired sera and SWMF at one- and six-months after third-dose lacked adaptive immunity cytokine expression. Innate immunity cytokines (MIG, MCP-1, IL-8, TNF-α, IL-6, IL-1β) showed a declining trend in serum, but were sustained in SWMF. Thus, our findings suggest that first-dose acts as an antibody boost, while second-dose induces antibody anergy in the previously COVID- exposed group. Rapidly declining antibodies and minimal T cell cytokines raises concerns over their durability in subsequent virus exposures. Sustained innate cytokines emanating from the oral mucosa warrant further in-depth explorations.
MAGE enables population level RNAseq driven genotyping and (differential) allelic divergence detection in healthy kidney and carcinoma
Authors: Cedric Stroobandt , Tine Goovaerts , Louis Coussement , Femke De Graeve , Floris Voorthuijzen , Laure Van Steenbergen , Jeroen Galle , Wim Van Criekinge , Tim De Meyer 
Published: September 2022

AbstractDecreasing sequencing costs have instigated large-scale RNAseq experiments, yet genetic polymorphisms in such data remain poorly exploited. Currently, allele-specific expression (ASE) studies focus almost exclusively on genetic variants explaining expression differences (cis-eQTLs), largely ignoring other ASE effects. The latter are typically associated with higher variance in expression of both copies of a gene, here called Allelic Divergence (AD). We therefore developed an RNAseq-driven population-level beta-binomial mixture model for (differential) AD detection. The model simultaneously enables RNAseq-driven genotyping, which outperforms alternative RNA genotyping methods when applied on healthy kidney data from The Cancer Genome Atlas. Moreover, we identify well-known non-cis-eQTL ASE, e.g. random monoallelic expression of HLA and immunoglobulin genes in healthy kidney, as well as allele-specific aberrations in clear cell kidney carcinoma, including long-range epigenetic silencing of protocadherins, copy-number alterations, and loss of imprinting. These methods are available as the Modeller of Allelic Gene Expression (MAGE) tool suite: https://biobix.github.io/MAGE/.
Failure analysis of a natural gas transmission X60 steel pipeline
Authors: Ma Yaxin , Zhang Hong , Gao Yifei , Men Zhengxing , He Ling , Cao Jianguo 
Published: September 2022

Purpose
This paper aims to investigate the reason for natural gas leakage from transmission pipelines between Linyi and Shouguang in China during sealing tests, explore the failure mechanism and provide a reference for taking reasonable measures to prevent such accidents.

Design/methodology/approach
Failure analysis for the steel pipe has been addressed with different methods, such as microstructure analysis, inclusion analysis, corrosion product analysis, macro- and micro-morphology analyses and bacterially catalyzed experiments.

Findings
Several bulges were observed, especially at the bottom of the steel pipe sample, with the distribution and positioning not related to the weld. The inner surface of the steel pipe was severely corroded, and the oxide scale was flaking in many places. The greatest corrosion area was identified at the bottom of the steel pipe near the gas leakage point. Severe pitting and perforation corrosion in the pipeline were observed, and the main corrosion reaction products were Fe3O4, FeO and FeS. The grain orientation distribution near the crack (coarse grains <101> and fine grains <111> at the microcrack tip) indicates that fine grains may be beneficial in hindering crack propagation.

Originality/value
The principal mechanism for the corrosion failure is supposed to be due to the interaction of chloride ions with the sulfate-reducing microorganisms present and the stress corrosion cracking by chloride and sulfide formed by the sulfate-reducing microorganisms.
Aviation operators (pilots, ATCOs) decision-making process
Authors: Kale Utku , Alharasees Omar , Rohacs Jozsef , Rohacs Daniel 
Published: September 2022

Purpose
The purpose of this paper is to investigate and evaluate the subjective decision-making of pilots during final approach with varying degrees of experience for landing and go-around.

Design/methodology/approach
In this research, the “Lorenz Attractor” was modified and used to model the subjective decision-making of pilots during the final approach. For landing and go-around situations, “hesitation frequency” and “decision-making time” were calculated for the subjective decision-making of pilots.

Findings
In this research, the modified Chaotic Lorenz Model was used on MATLAB with varying degrees of experience, namely, student pilots, less-skilled pilots, experienced pilots and well-experienced pilots. Based on the outcomes, the less-skilled pilot needs nearly four times more decision-making time on landing or go-around compared to the well-experienced pilot during the final approach.

Practical implications
Operators (pilots, air traffic controllers) need to make critical and timely decisions in a highly complex work environment, which is influenced by several external elements such as experience level and human factors. According to NASA, 80% of aviation accidents occur due to human errors specifically over the course of the aviation decision-making process in dynamic circumstances. Due to the consequences of this research the operators' training should be redesigned by assisting flight instructors on the weaknesses of pilots.

Originality/value
This research explores the endogenous dynamics of the pilot decision-making process by applying a novel “Chaotic Lorenz Model” on MATLAB. In addition, the operator's total decision time formula was improved by including the decision reviewing time and external factors. Moreover, subjective decision-making model created by the current authors and Wicken's information model were modified to the highly automated systems.
Audit committee characteristics and corporate philanthropic donations before and during COVID-19
Authors: Umar Umar Habibu , Jibril Abubakar Isa , Musa Sulaiman 
Published: September 2022

Purpose
This study aims to examine the effects of audit committee attributes on corporate philanthropic donations before and during the COVID-19 pandemic.

Design/methodology/approach
The study targets Nigeria’s listed firms between 2019 and 2020. We hand-collected the data from the available published annual reports of 141 and 128 firms for 2019 and 2020, respectively. Therefore, the authors used a total of 269 firm-year observations for the study. The authors used ordinary least square regression to analyze the data and Tobit regression to establish the robustness of the results.

Findings
The results indicate that the frequency of audit committee meetings has a significant positive relationship with corporate philanthropic donations before and during COVID-19. In the case of audit committee independence, it has only a significant positive relationship with corporate philanthropic donations during the pandemic. However, the findings reveal that audit committee size and foreign directors on the audit committee do not influence corporate philanthropic donations before and during COVID-19.

Research limitations/implications
The study considers audit committee characteristics out of the corporate governance mechanisms that can influence the philanthropic donations of the listed firms in Nigeria over two years from 2019 and 2020.

Practical implications
The findings have practical implications for encouraging the audit committee to support philanthropic donations for the welfare of the poor and the needy, particularly in difficult times like the COVID-19 period. The results could also help regulators and policymakers to provide regulations and policies that can encourage firms to participate actively in philanthropic activities to their best ability.

Social implications
Motivating firms to provide philanthropic donations for the welfare of underprivileged persons could strongly support the government’s effort to minimize the socioeconomic problems caused by COVID-19.

Originality/value
The study contributes to the scant literature that establishes the impact of audit committee attributes on firm philanthropic donations toward helping the poor and the needy in difficult periods.
Take-off, turbulence and turnaround
Authors: Forseth Ulla 
Published: September 2022

PurposeThe aim of this paper is to explore the evolving nature of the work of cabin crew in a Scandinavian carrier in three eras, drawing on theories of gender and emotional labour.Design/methodology/approachThe paper draws on ethnographic data from fieldwork, interviews and documents.FindingsFrom being a feminized and temporary occupation for young, upper- and middle-class women in the 1970s, the occupation became a full-time job and with greater diversity of cabin crew. Today there are signs of the job becoming a precarious and temporary one of demanding and devalorized work in a polarized and class-divided labour market. Changing circumstances impact on the emotional labour requirement and terms and conditions at work.Research limitations/implicationsA limitation is that the research design was not initially longitudinal in the sense that the author does not have exactly the same kind of data from each era. The author has, however, been involved in this field for two decades, used multiple methods and interacted with different stakeholders and drew on a unique data material.Practical implicationsThe development in aviation is contributing to new discriminatory practices, driving employee conditions downwards and changing the job demands. This development will have practical consequences for the lives and families of cabin crew.Social implicationsThe analysis illustrates how work ‘constructs' workers and contributes in creating jobs that are not sustainable for the employees. Intensification of work, insecurity and tougher working conditions also challenge key features in the Nordic model such as proper pay, decent work and a life-long employment. Much indicates that the profession is again becoming a temporary one of demanding work with poor working conditions in a polarized and class-divided labour market.Originality/valueThe research contributes to the literature on emotional labour, gender and the evolving nature of the work of cabin crew. The unique data material, the longitudinal aspect of the research and the focus on a single network carrier are good in charting changes over time.
Financial capability: a systematic conceptual review, extension and synthesis
Authors: Xiao Jing Jian , Huang Jin , Goyal Kirti , Kumar Satish 
Published: September 2022

PurposeThis study aims to examine the literature on consumer financial capability. By analyzing the research trends, theories, definitions and themes, the literature on financial capability is synthesized, and agenda for future research is suggested. A framework is presented that portrays the antecedents as well as the outcomes of financial capability and their interlinkages.Design/methodology/approachFollowing a systematic approach, the review is based on 215 articles published during January 2007 and–March 2022, retrieved from Scopus. It presents the definitions and theories of financial capability, publication trends, influential articles, prominent authors, prolific journals and countries publishing on financial capability. Using bibliographic coupling, the intellectual structure of the topic is explored, along with offering a framework through content analysis.FindingsThe bibliographic coupling analysis identifies four major clusters of research themes and capability theory appeared to be the most prominent theory. The synthesis draws upon five conceptual definitions of financial capability. Based on the discussion, in this review, financial capability is defined as an individual ability to apply appropriate financial knowledge, perform desirable financial behaviors and take available financial opportunities for achieving financial well-being. A conceptual framework delineates the synthesized literature and propositions based on this framework and relevant research are proposed. Finally, directions for future research are discussed.Originality/valueThis paper is an attempt to offer a comprehensive synthesis of the scholarship on financial capability and its conceptualization. It further proposes an extensive future research agenda. The study has implications for financial services providers relating to retail bank marketing.
The global impact of management on soil nematode abundances
Authors: White Hannah J. 
Published: September 2022

AbstractResearch Highlight: Li, X., Liu, T., Li, H., Geisen, S., Hu, F., & Liu, M. (2022). Management effects on soil nematode abundance differ among functional groups and land‐use types at a global scale. Journal of Animal Ecology, https://doi.org/10.1111/1365‐2656.13744. Despite the well‐documented decline of aboveground species abundances as a result of land‐use intensification, there has been little attention on the effects of human activities on belowground species abundances. Li et al. analyse nematode data, the most abundant animal on the planet, from across the globe to determine whether their abundances vary between managed and unmanaged habitats. The authors show that, unlike aboveground biodiversity, nematode abundance is higher in managed than unmanaged primary and secondary habitats. Furthermore, responses to land management vary between trophic groups and they do not appear to follow the general hypothesis that higher trophic levels are more vulnerable to human activity than those further down the food chain, except in urban habitats. Finally, Li et al. show that the relationships between environmental predictors and species abundance were weakened (and sometimes reversed) in managed habitats. Together, their results reveal how land‐use management is impacting the trophic composition of soil nematode communities and their relationships with the environment, which has implications for ecosystem functioning.
Debunking Murray‐Darling Basin water trade myths
Authors: Wheeler Sarah Ann 
Published: September 2022

AbstractAustralia, and particularly the Murray–Darling Basin (MDB), has the most mature and adopted water markets globally. Water trading is an important policy tool to deal with water scarcity issues, demonstrating allocative, dynamic and productive efficiency benefits. At the same time, water markets have been controversial in Australia. Markets have been blamed for a range of issues, including claims of unsustainability, inequity, farm bankruptcy, farmer distress and farm exit. This study reviews the MDB water trade literature and finds little evidence to support such myths. Arguably, the biggest misconception is that critics do not separate water markets from the meta‐governance institutional structures that define them. Perceived water market failures are often due to governance issues – not water trade per se. This is not to say that market failure does not exist, it does, and indeed, there are also serious distributional issues that need addressing (e.g., water property entitlements for indigenous stakeholders). As such, water market design and governance need to adapt and evolve as problems arise and the market matures. However, in an era of increasing water scarcity, enabling water trade remains one of the most important instruments available to assist in water sharing, reallocation and farm adaptation to climate change.
Of critical importance: Toward a quantitative probabilistic risk assessment framework for critical infrastructure
Authors: Nas Ivo , Helsloot Ira , Cator Eric 
Published: September 2022

AbstractCritical comments can be made to the current risk assessment framework for critical infrastructure used in The Netherlands: the Dutch National Risk Assessment (DNRA). The DNRA uses a qualitative approach to risk assessment, based on, for example, ordinal risk scoring and the risk matrix. Even though qualitative risk assessment methods are internationally popular, there is no scientific evidence that a qualitative approach to risk assessment actually works. In the case of the DNRA, the main points of criticisms relate to the usage of a subjective concept of risk, dependency on subjective risk experts, the use of risk matrices and the absence of decision rules. To combat these criticisms, this article proposes a quantitative probabilistic risk assessment framework for critical infrastructure based upon four design principles, that a methodologically justified risk assessment method for critical infrastructure should meet. The proposal made for the quantitative risk assessment framework uses a Bayesian approach, a standardized measure for negligible risk in the form of a yearly mortality probability of 10−6, and Disability Adjusted Life Years to quantify human life years for social cost–benefit analysis. Finally, the proposed quantitative method is demonstrated in a case study.