bluuebunny/crossref_metadata_2025_split huggingface dataset:
Education and Consultation Needs of Social Workers in Practice with Rural Older Adults
Authors: Ilardo Joan , Zell Angela M , Haque Raza , Ensberg Mark 
Published: June 2022

Abstract
The aging population and shortage of primary care physicians lead to increasing gaps in access to rural geriatric healthcare. Of concern is the lack of access to geriatric expertise, leading to adverse effects on rural older adults’ health outcomes and quality of life. The Geriatric Rural Extension of Expertise through Telegeriatric Services (also known as GREETS) project surveyed rural physical and behavioral healthcare practitioners to identify gaps in geriatric competencies in the rural workforce. Using the Qualtrics platform, a survey was distributed to professional membership lists throughout the State of Michigan. A total of 106 responses were completed, of which 50 were from respondents who identified their profession as a social worker. As would be expected based on social workers’ scope of practice and the settings in which they provide services, social worker respondents noted a higher need than the other practitioner respondents for education related to (a) managing chronic pain, (b) managing care of patients with multiple chronic conditions, (c) having serious illness conversations, (d) diagnosing dementia, and (e) discussing advance care planning. Having identified these needs provides a basis for identifying and implementing training and resources for social work and other disciplines involved in geriatric care and services.
Urban chronic diseases management through promoting low carbon lifestyle and physical activities
Authors: Liu Kun , Wang Hong , Wang Weixiang , Ming Li , Wei Guqiang , Liang Huaqing , He Zirui , Liu Guangdong , Xu Chen , Liu Xua 
Published: June 2022

Abstract
Achieving carbon emission peak by 2030 and carbon neutrality by 2060 is China’s long-term climate change strategy for the 21st century in accordance with the provisions of the Paris Agreement. Achieving carbon emission peak and carbon neutrality have caused a profound change in the society, which not only requires energy conservation and carbon emission reduction of all walks of life, but also profoundly affects people’s lifestyles. In the current carbon emission reduction research, low-carbon lifestyles tends to focus on the relationship between human behavior and energy conservation. This paper starts from a new perspective, low-carbon lifestyle and health, focuses on the community fitness activity environment in the construction of complete residential communities, seizes the Combination of Physical-Medical Therapy national policy, improves people’s health on the basis of advocating fitness activities and reducing medical travel, closely links low-carbon, health and community construction, and endows the low-carbon community with a health function. Studies have shown that regular exercise can effectively prevent and manage many urban chronic diseases. By carefully selecting the prevalent chronic diseases and population disability adjustment years, this paper presents the characteristics of chronic diseases in major China provinces. Taking into account popular fitness activities, this paper innovatively puts forward the ‘urban chronic disease community physical activity management model’. At the same time, it proposes the community fitness and activity infrastructure design and build strategies to manage urban chronic diseases. At the end of the article, it gives an actual project case of fitness and activity environment and puts forward the suggestion of establishing ‘Living Laboratory for Community Fitness and Activity’ as the test bed to collect big data for follow-up study.
Sensitivity analysis of road tunnel resilience through data-driven stochastic simulation
Authors: Khetwal Sandeep , Gutierrez Marte , Pei Shiling 
Published: June 2022

Abstract
A probabilistic resilience model for tunnels exposed to disruptive events is vital to understanding and estimating the functionality loss and its recovery time due to these events. Performing sensitivity analysis will help to identify the critical parameters contributing to tunnel resilience. This paper aims to identify tunnel resilience’s sensitivity for parameters such as traffic volume, fire suppression systems, changes in maintenance, and operation parameters using a simulation model that estimates overall tunnel resilience for a given period. Overall universal compatibility of the simulation model is checked for twenty-two tunnels using information from the US National Tunnel Inventory (NTI), and resilience correlation is established. The results show that resilience loss due to fire and accidents are directly correlated with traffic volume. A significant reduction in the loss due to fire can be found by installing a fire suppression system. Increasing the service life of equipment and frequency of inspection and repair contributes to an increase in a tunnel’s resilience index. A resilience correlation study for the twenty-two tunnels showed that an average resilience index for these tunnels is 96.57%. Linear correlations can be made between tunnel length and traffic loss due to fire and operation. Accidents and fire events are correlated with average traffic in the tunnel. Tunnel speed limit, age, number of lanes, and bores do not show a considerable effect on disruptive events. Overall, the study shows that the proposed simulation model can encompass various disruptive events to estimate the resilience of the tunnel.
Acute stress deteriorates breast meat quality of Ross 308 broiler chickens by inducing redox imbalance and mitochondrial dysfunction
Authors: Liao Hongju , Zhang Lin , Li Jiaolong , Xing Tong , Gao Feng 
Published: June 2022

Abstract
This study investigated the effects of acute stress on breast meat quality, redox status, and mitochondrial function in pectoralis major (PM) muscle of broilers. A total of 168 broiler chickens (42-d-old, Ross 308) were randomly divided into control (CON) and preslaughter transport (T) treatments. A broiler was an experimental unit. Each treatment consisted of 84 broilers, and they were put in 12 crates with 7 broilers each. Broilers in the T group were transported according to a designed protocol, and the CON broilers were kept in crates under normal living conditions before slaughtering. Based on the meat quality traits assessed at postmortem 24 h, all PM muscles of the transported broilers were further classified into normal (T-NOR) and pale, soft, and exudative (PSE)-like (T-PSE) groups for the determination of redox status in PM muscle and isolated mitochondria, energy metabolites, mitochondrial electron transport chain complexes activities, as well as mitochondrial function-modulating genes expression. Compared with CON, the extent of lipid peroxidation as well as protein oxidation were significantly increased in both PM muscles and mitochondria in T-PSE (P &lt; 0.05), whereas not in T-NOR. Higher activities of glutathione peroxidase, total superoxide dismutase, and Cu–Zn superoxide dismutase were observed in PM muscle of T-NOR broilers when compared with CON (P &lt; 0.05). Preslaughter transport increased the generation of reactive oxygen species, as well as enhanced antioxidant capacity in PM mitochondria of broilers (P &lt; 0.05). Compared with CON, the ATP content, activities of complexes I and III, as well as relative mitochondrial membrane potential and swelling were significantly decreased in T-PSE (P &lt; 0.05), whereas no significant changes in either ATP content or complex I activity were observed in T-NOR. Preslaughter transport enhanced the mRNA expression of regulators involved in the glutathione system, thioredoxin 2 system, and mitochondrial biosynthesis in PM muscle of broilers (P &lt; 0.05). Moreover, we noticed a more evident enhancement effect in T-NOR than in T-PSE (P &lt; 0.05). Overall, this work indicates that acute stress-induced redox imbalance and mitochondrial dysfunction have significant implications for the development of PSE-like meat.
Breast Density Legislation Impact on Breast Cancer Screening and Risk Assessment
Authors: Kothari Pranay , Tseng Joseph J , Chalfant James S , Pittman Sarah M , Hoyt Anne C , Larsen Linda , Sheth Pulin , Yamashita Mary , Downey John , Ikeda Debra M 
Published: June 2022

Abstract

Objective
To evaluate breast density notification legislation (BDNL) on breast imaging practice patterns, risk assessment, and supplemental screening.

Methods
A 20-question anonymous web-based survey was administered to practicing Society of Breast Imaging radiologists in the U.S. between February and April 2021 regarding breast cancer risk assessment, supplemental screening, and density measurements. Results were compared between facilities with and without BDNL using the two-sided Fisher’s exact test.

Results
One hundred and ninety-seven radiologists from 41 U.S. states, with (187/197, 95%) or without (10/197, 5%) BDNL, responded. Fifty-seven percent (113/197) performed breast cancer risk assessment, and 93% (183/197) offered supplemental screening for women with dense breasts. Between facilities with or without BDNL, there was no significant difference in whether risk assessment was (P = 0.19) or was not performed (P = 0.20). There was no significant difference in supplemental screening types (P &gt; 0.05) between BDNL and non-BDNL facilities. Thirty-five percent (69/197) of facilities offered no supplemental screening studies, and 25% (49/197) had no future plans to offer supplemental screening. A statistically significant greater proportion of non-BDNL facilities offered no supplemental screening (P &lt; 0.03) and had no plans to offer supplemental screening compared to BDNL facilities (P &lt; 0.02).

Conclusion
Facilities in BDNL states often offer supplemental screening compared to facilities in non-BDNL states. Compared to BDNL facilities, a statistically significant proportion of non-BDNL facilities had no supplemental screening nor plans for implementation. Our data suggest that upcoming federal BDNL will impact how supplemental screening is addressed in currently non-BDNL states.
Egg Predation by Phytoseiid Predatory Mites: Is There Intraguild Predation Towards Predatory Bug Eggs?
Authors: Vangansbeke Dominiek , Duarte Marcus V A , Pijnakker Juliette , Pekas Apostolos , Wäckers Felix 
Published: June 2022

Abstract
Phytoseiid predatory mites are efficient biocontrol agents of important thrips pests, such as the western flower thrips, Frankliniella occidentalis Pergande (Thysanoptera: Thripidae). Until recently, it was believed that first instars, and to a lesser extent second instars, were the most vulnerable developmental stages of thrips to be attacked by phytoseiids. However, recent evidence showed that some phytoseiids can detect and prey upon thrips eggs inserted in the leaf tissue. As phytoseiid predatory mites often co-occur with other beneficial insects, such as mirid and anthocorid predatory bugs which also insert their eggs inside leaf material, this raises the question whether phytoseiid predatory mites may also feed on predatory bug eggs. Here we first tested the potential of Amblyseius swirskii Athias-Henriot, Transeius montdorensis Schicha, and Amblydromalus limonicus Garman and McGregor (Acari: Phytoseiidae) to kill eggs of F. occidentalis in leaf tissue. Secondly, we tested whether those phytoseiids were capable of killing eggs of Orius laevigatus Fieber (Hemiptera: Anthocoridae), Macrolophus pygmaeus Rambur and Nesidiocoris tenuis (Reuter) (Hemiptera: Miridae), three biocontrol agents that also insert their eggs inside plant tissue. Our results showed that A. swirskii and A. limonicus could kill thrips eggs, whereas T. montdorensis could not. Furthermore, we show that the presence of phytoseiid predatory mites does not affect the hatch rate of predatory bugs that insert their eggs inside leaves.
Atomic-resolution STEM image denoising by total variation regularization
Authors: Kawahara Kazuaki , Ishikawa Ryo , Sasano Shun , Shibata Naoya , Ikuhara Yuichi 
Published: June 2022

Abstract
Atomic-resolution electron microscopy imaging of solid-state material is a powerful method for structural analysis. Scanning transmission electron microscopy (STEM) is one of the actively used techniques to directly observe atoms in materials. However, some materials are easily damaged by the electron beam irradiation, and only noisy images are available when we decrease the electron dose to avoid beam damages. Therefore, a denoising process is necessary for precise structural analysis in low-dose STEM. In this study, we propose total variation (TV) denoising algorithm to remove quantum noise in an STEM image. We defined an entropy of STEM image that corresponds to the image contrast to determine a hyperparameter and we found that there is a hyperparameter that maximizes the entropy. We acquired atomic-resolution STEM image of CaF2 viewed along the [001] direction and executed TV denoising. The atomic columns of Ca and F are clearly visualized by the TV denoising, and atomic positions of Ca and F are determined with the error of ±1 pm and ±4 pm, respectively.
Performances of Trust: Ritualized Diplomacy in Southeast Asian Regionalism
Authors: Davies Mathew 
Published: June 2022

AbstractWhat happens when trust ends? This article identifies a hitherto overlooked possibility, a performance of trust. Comprising ritualized diplomacy, performances of trust communicate the products of trust, the values that define membership of an international organization, but do not constitute those values. Realizing the obscuring, subjunctive, orthopraxic, and located nature of these ritual performances helps distinguish performance from other social processes of identity and interest construction. Demonstrated in the context of Southeast Asian regionalism, performances of trust suggest the relevance of trust in explaining what states and their leaders say and do may outlive the presence of trust itself.
Incidence of Intussusception in Bamako, Mali, Before and After the Introduction of Rotavirus Vaccine
Authors: Roose Anna , Keita Adama Mamby , Tapia Milagritos D , Sow Samba O , Mast T Christopher , Kotloff Karen L 
Published: June 2022

Abstract
Pentavalent rotavirus vaccine has been associated with a small increase in intussusception, but pre- and post-introduction data are lacking in many low-resource settings. Using chart review and prospective surveillance data, intussusception incidence was estimated in Bamako, Mali. The mean annual intussusception incidence post-introduction was not significantly different from that of pre-introduction.
Race Differences in Veteran’s Affairs Emergency Department Utilization
Authors: Rothmiller Shamira J , Lund Brian C , Burgess Diana J , Lee Sangil , Hadlandsmyth Katherine 
Published: June 2022

ABSTRACT

Introduction
African Americans (AAs) experience disparities in chronic pain care. This study aimed to identify the rates of emergency department (ED) utilization for visits associated with chronic pain diagnoses among AAs compared to Whites and to determine variables that accounted for any differences.

Methods
This retrospective observational study used national Veterans Affairs (Veteran’s Health Administration) administrative data to identify Veterans with chronic pain diagnoses in 2018. Race/ethnicity was self-reported and assessed to examine if differences exist in ED utilization. Differences between AAs and Whites were examined using negative binomial regression models, controlling for ethnicity. Multivariable models (including demographics, pain characteristics, psychiatric comorbidities, medical comorbidities, pain-related health care utilization, and medication utilization) were examined to determine factors that contributed to these disparities.

Results
Among the 2,261,030 patients, 22% (n = 492,138) were AA. The incidence rate ratio of ED utilization for AAs, relative to Whites, was 1.58 (95% CI: 1.56–1.59). The only independent variable that produced a clinically meaningful reduction in the race effect on ED use was rurality, which was associated with reduced ED use. Post hoc model including all variables reduced the race effect to 1.37 (95% CI: 1.36–1.38).

Conclusion
AA Veterans had a 58% greater risk of ED utilization for visits associated with chronic pain diagnoses relative to White Veterans, which remained meaningfully elevated after adjustment for observable confounders (37%). This observation may reflect disparities in outpatient chronic pain care for AAs. Future research could focus on enhancing therapeutic alliance in primary care to improve chronic pain treatment for AAs.
The elusive transcriptional memory trace
Authors: Gil-Marti Beatriz , Barredo Celia G , Pina-Flores Sara , Trejo Jose Luis , Turiegano Enrique , Martin Francisco A 
Published: June 2022

Abstract
Memory is the brain faculty to store and remember information. It is a sequential process in which four different phases can be distinguished: encoding or learning, consolidation, storage and reactivation. Since the discovery of the first Drosophila gene essential for memory formation in 1976, our knowledge of its mechanisms has progressed greatly. The current view considers the existence of engrams, ensembles of neuronal populations whose activity is temporally coordinated and represents the minimal correlate of experience in brain circuits. In order to form and maintain the engram, protein synthesis and, probably, specific transcriptional program(s) is required. The immediate early gene response during learning process has been extensively studied. However, a detailed description of the transcriptional response for later memory phases was technically challenging. Recent advances in transcriptomics have allowed us to tackle this biological problem. This review summarizes recent findings in this field, and discusses whether or not it is possible to identify a transcriptional trace for memory.
Development of Agrobacterium tumefaciens Infiltration of Infectious Clones of Grapevine Geminivirus A Directly into Greenhouse-Grown Grapevine and Nicotiana benthamiana Plants
Authors: Kuo Yen-Wen , Bednarska Alicja , Al Rwahnih Maher , Falk Bryce W. 
Published: June 2022

Grapevine virus infectious clones are important tools for fundamental studies, but also because of their potential for translational applications for grapevine improvement. Although several grapevine virus infectious clones have been developed, there has been difficulty in directly infecting mature grapevine plants, and many of the viruses used still cause disease symptoms in grapevine plants, making them less likely candidates for biotechnological applications in grapes. Here, we developed an improved Agrobacterium tumefaciens infiltration method that can be used to deliver DNA plasmids and viral infectious clones directly into approximately 20- to 40-cm-high (above soil) greenhouse-grown grapevine plants. We also developed infectious clones for two isolates of grapevine geminivirus A (GGVA): Longyan (China; GenBank accession KX570611; GGVA-76) and Super Hamburg (Japan; GenBank accession KX570610; GGVA-93). Neither virus caused any obvious symptoms when inoculated to plants of grapevine varieties Colombard, Salt Creek, Cabernet Sauvignon, and Vaccarèse. However, the two GGVA isolates induced different symptom severity and viral titer in Nicotiana benthamiana plants. The two GGVA isolates used here were found to accumulate to different titers in different parts/branches of the infected grapevine plants. The GGVA infectious clones and the improved grapevine infiltration technique developed here provide new, valuable tools that can be applied to grapevine plants, possibly even for translational applications such as disease management and desired trait improvements.
Differentiation and prognostic stratification of acute myeloid leukemia by serum‐based spectroscopy coupling with metabolic fingerprints
Authors: Duan Zhengwei , Chen Yang , Ye Minlu , Xiao Lijing , Chen Yanxin , Cao Yingping , Peng Yi , Zhang Jingling , Zhang Yu , Yang Ting , Liu Wuping , Feng Shangyuan , Hu Jianda 
Published: June 2022

AbstractAcute myeloid leukemia (AML) is a heterogeneous disease characterized by complex molecular and cytogenetic abnormalities. New approaches to predict the prognosis of AML have increasingly attracted attention. There were 98 non‐M3 AML cases and 48 healthy controls were enrolled in the current work. Clinically routine assays for cytogenetic and molecular genetic analyses were performed on the bone marrow samples of patients with AML. Meanwhile, metabolic profiling of these AML subjects was also performed on the serum samples by combining Ag nanoparticle‐based surface‐enhanced Raman spectroscopy (SERS) with proton nuclear magnetic resonance (NMR) spectroscopy. Although most of the routine biochemical test showed no significant differences between the M0–M2 and M5 groups, the metabolic profiles were significantly different either between AML subtypes or between prognostic risk subgroups. Specific SERS bands were screened to serve as potential markers for AML subtypes. The results demonstrated that the classification models for M0–M2 and M5 shared two bands (i.e., 1328 and 741 cm−1), all came from nucleic acid signals. Furthermore, Metabolic profiles provided various differential metabolites responsible for different AML subtypes, and we found altered pathways mainly included energy metabolism like glycolysis, pyruvate metabolism, and metabolisms of nucleic acid bases as well as specific amino acid metabolisms. It is concluded that integration of SERS and NMR provides the rational and could be reliable to reveal AML differentiation, and meanwhile lay the basis for experimental and clinical practice to monitor disease progression and prognostic evaluation.
Oliguria on the Day of Intubation Is Associated With Mortality in Patients With Acute Respiratory Distress Syndrome
Authors: Fadel Raef A. , Murskyj Ivanna , Abou Asala Elian , Nasiri Nour , Alsaadi Ayman , Scott Ashley , Ouellette Daniel 
Published: June 2022

OBJECTIVES:
To investigate the relationship between oliguric acute kidney injury (AKI) and mortality in patients with acute respiratory distress syndrome (ARDS).

DESIGN:
Retrospective cohort study.

SETTING:
This investigation took place at a single-center, tertiary referral multidisciplinary comprehensive healthcare hospital in metropolitan Detroit, Michigan.

PATIENTS:
Adult patients 18 years old or older hospitalized in the ICU and diagnosed with ARDS on mechanical ventilation.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Three hundred eight patients were included in the final analysis. Risk factors associated with mortality included advanced age (p < 0.001), increased body mass index (p = 0.008), and a history of chronic kidney disease (p = 0.023). Presence of AKI by day 1 of intubation, with elevated creatinine (p = 0.003) and oliguria (p < 0.001), was significantly associated with mortality. On multivariate analysis, advanced age (relative risk [RR], 1.02), urine output on the day of intubation (RR, 0.388), bicarbonate level (RR, 0.948), and Sequential Organ Failure Assessment severity score (RR, 1.09) were independently associated with mortality. A receiver operating characteristic curve identified a threshold urine output on the day of intubation of 0.7 mL/kg/hr (area under the curve, 0.75; p < 0.001) as most closely associated with inpatient mortality (i.e., urine output < 0.7 mL/kg/hr is associated with mortality).

CONCLUSIONS:
For patients with ARDS, oliguria on the day of intubation was independently associated with increased mortality. Urine output of less than 0.7 mL/kg/hr predicted 80% of inpatient deaths. These findings herald an augmented understanding of the role of urine output in medical decision-making and prognostication.