bluuebunny/crossref_metadata_2025_split huggingface dataset:
FORMATION OF COMMUNICATIVE COMPETENCE OF FUTURE PRIMARY SCHOOL TEACHERS IN MODERN CONDITIONS
Authors: Baidiuk Liubov 
Published: November 2022

The article highlights the process of the formation of communicative competence of future primary school teachers in modern conditions. It was established that the problem of revealing the essence of communicative competence is based on an interdisciplinary space, as it includes pedagogical aspects, linguistic, psychological and methodical (communicative qualities of language, literary norm, text, communication, language activity, types of language activity, motives of language activity, and language ethics). The scientific literature was analyzed, the communication of applicants and teachers was observed in various situations, on the basis of which it was established that the professional training of the future teacher in the direction of communicative culture is insufficient and the reserves available in higher education institutions for this are not fully used; a significant part of students during the period of pedagogical practices experience serious difficulties in managing the educational activities of students in the mode of explanatory-reproductive, problem-based, developmental and other types of learning and in organizing the corresponding types of communication training. The understanding of communicative competence as a complex personal characteristic containing communicative abilities and skills, psychological and pedagogical knowledge, personality properties, psychological states in communication with people is revealed. It has been proven that communicative competence is not reduced either to pedagogical abilities or to an ensemble of personal traits, since the teacher’s interpretation turns out to be one-sided. Two interrelated and interdependent levels of communicative competence are distinguished: the first level determines the manifestation of communicative competence in communication, communicative behavior of a person, the second includes communicative values, the orientation and specificity of the teacher’s motivation, his need for communication and includes communication skills and abilities, as well as psychological-pedagogical knowledge. It has been established that the basis of communicative competence is the communicative core of the personality, which is manifested through communicative abilities, and they, in turn, through the formed communicative skills. Four interrelated components of the communicative competence of the future primary school teacher are distinguished: basic, content, operational, reflective. It is proposed to shift the emphasis from scientific subject training to communicative training, since the implementation of the idea of communicative dominance should contribute to increasing the effectiveness of the process of forming the communicative competence of the future primary school teacher.
Keywords: formation; communicative competence; future teachers; elementary school; communicative core; preparation; communicative qualities; communication; language activity.
THE ROLE OF ACMEOLOGICAL APPROACH IN THE PROFESSIONAL TRAINING OF FUTURE FOREIGN LANGUAGES TEACHERS IN INSTITUTIONS OF HIGHER EDUCATION
Authors: Kolisnichenko Anhelina 
Published: November 2022

The article analyzes the role of the acmeological approach in the future foreign language teacher training by investigating the main aspects that are as follows: study of the future FL teachers’ personal qualities and abilities, methods of raising their motivation and developing learner autonomy, opportunities for carrying out scientific research and studying the level of higher education institutions readiness to improve the quality of education. It was determined that the development of personal qualities and abilities, as well as the formation of professional competencies, is carried out as a consequence of the acmeological approach, which is integrated into the content of the educational program disciplines compiled for future teachers of foreign languages (English and German). The impact of various motivation types on the acmeological development of future foreign language teachers is clarified and intrinsic motivation is defined as the one that has the greatest stimulus to study. An overview of the possibilities for involving higher education students in research activities was carried out, as a result of which it was recommended to involve future teachers of foreign languages more widely in the realization of their scientific potential. A review of the readiness level of higher education institutions to improve the quality of teacher training has shown that there are positive changes that contribute to the effective process of education, but some recommendations have been identified that will intensively contribute to this process.
Keywords: acmeological approach; future foreign languages teacher training; German language; English language; educational program; institutions of higher education; professional competencies; the content of education; motivation; self-development.
A likely HOXC4 predisposition variant for Chiari malformations
Authors: Brockmeyer Douglas L. , Cheshier Samuel H. , Stevens Jeff , Facelli Julio C. , Rowe Kerry , Heiss John D. , Musolf Anthony , Viskochil David H. , Allen-Brady Kristina L. , Cannon-Albright Lisa A. 
Published: November 2022

OBJECTIVE
Inherited variants predisposing patients to type 1 or 1.5 Chiari malformation (CM) have been hypothesized but have proven difficult to confirm. The authors used a unique high-risk pedigree population resource and approach to identify rare candidate variants that likely predispose individuals to CM and protein structure prediction tools to identify pathogenicity mechanisms.

METHODS
By using the Utah Population Database, the authors identified pedigrees with significantly increased numbers of members with CM diagnosis. From a separate DNA biorepository of 451 samples from CM patients and families, 32 CM patients belonging to 1 or more of 24 high-risk Chiari pedigrees were identified. Two high-risk pedigrees had 3 CM-affected relatives, and 22 pedigrees had 2 CM-affected relatives. To identify rare candidate predisposition gene variants, whole-exome sequence data from these 32 CM patients belonging to 24 CM-affected related pairs from high-risk pedigrees were analyzed. The I-TASSER package for protein structure prediction was used to predict the structures of both the wild-type and mutant proteins found here.

RESULTS
Sequence analysis of the 24 affected relative pairs identified 38 rare candidate Chiari predisposition gene variants that were shared by at least 1 CM-affected pair from a high-risk pedigree. The authors found a candidate variant in HOXC4 that was shared by 2 CM-affected patients in 2 independent pedigrees. All 4 of these CM cases, 2 in each pedigree, exhibited a specific craniocervical bony phenotype defined by a clivoaxial angle less than 125°. The protein structure prediction results suggested that the mutation considered here may reduce the binding affinity of HOXC4 to DNA.

CONCLUSIONS
Analysis of unique and powerful Utah genetic resources allowed identification of 38 strong candidate CM predisposition gene variants. These variants should be pursued in independent populations. One of the candidates, a rare HOXC4 variant, was identified in 2 high-risk CM pedigrees, with this variant possibly predisposing patients to a Chiari phenotype with craniocervical kyphosis.
Recurrent pediatric infratentorial ependymomas: a systematic review and meta-analysis on outcomes and molecular classification
Authors: Montgomery Eric Y. , Thirunavu Vineeth , Pagadala Manasa , Shlobin Nathan A. , Plant-Fox Ashley S. , Lam Sandi , DeCuypere Michael 
Published: November 2022

OBJECTIVE
The aim of this study was to summarize the prognosis of recurrent infratentorial ependymomas based on treatment and molecular characterization.

METHODS
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the authors searched the PubMed, Scopus, Embase, and Ovid databases for studies on recurrent infratentorial ependymomas in patients younger than 25 years of age. Exclusion criteria included case series of fewer than 5 patients and studies that did not provide time-dependent survival data.

RESULTS
The authors’ database search yielded 482 unique articles, of which 18 were included in the final analysis. There were 479 recurrent infratentorial pediatric ependymomas reported; 53.4% were WHO grade II and 46.6% were WHO grade III tumors. The overall mortality for recurrent infratentorial pediatric ependymomas was 49.1% (226/460). The pooled mean survival was 30.2 months after recurrence (95% CI 22.4–38.0 months). Gross-total resection (GTR) was achieved in 243 (59.0%) patients at initial presentation. The mean survival postrecurrence for those who received initial GTR was 42.3 months (95% CI 35.7–47.6 months) versus 26.0 months (95% CI 9.6–44.6 months) for those who received subtotal resection (STR) (p = 0.032). There was no difference in the mean survival between patients who received GTR (49.3 months, 95% CI 32.3–66.3 months) versus those who received STR (41.4 months, 95% CI 11.6–71.2 months) for their recurrent tumor (p = 0.610). In the studies that included molecular classification data, there were 169 (83.3%) posterior fossa group A (PFA) tumors and 34 (16.7%) posterior fossa group B (PFB) tumors, with 28 tumors harboring a 1q gain. PFA tumors demonstrated worse mean postprogression patient survival (24.7 months, 95% CI 15.3–34.0 months) compared with PFB tumors (48.0 months, 95% CI 32.8–63.2 months) (p = 0.0073). The average postrecurrence survival for patients with 1q+ tumors was 14.7 months.

CONCLUSIONS
The overall mortality rate for recurrent infratentorial ependymomas was found to be 49.1%, with a pooled mean survival of 30.2 months in the included sample population. More than 80% of recurrent infratentorial ependymomas were of the PFA molecular subtype, and both PFA tumors and those with 1q gain demonstrated worse prognosis after recurrence.
Implementasi aplikasi order penjualan online berbasis android pada UMKM Surya Jenangan di desa Jenangan Kecamatan Jenangan Kabupaten Ponorogo
Authors: Sari Chanif , Pandowo Hedi 
Published: November 2022

Salah satu sektor yang sangat terpukul oleh pandemi Covid-19 adalah Usaha Mikro, Kecil, dan Menengah (UMKM), yang juga menyumbang turunnya perekonomian nasional. Hal ini bisa dipahami karena UMKM mempunyai kontribusi yang sangat besar dalam perekonomian nasional. Kementerian Koperasi dan UKM mencatat hingga Februari 2022 sudah 17,25 juta pelaku UMKM yang terhubung ke dalam ekosistem digital. Sedangkan menurut data dari Kompas.com pengguna internet di Indonesia pada awal 2022 ini dilaporkan mencapai 210 juta jiwa. Dari jumlah ini, mayoritas pengguna mengakses internet lewat ponsel untuk membuka media sosial. Oleh karena itu penting sebagai pelaku bisnis untuk menggunakan tools berupa aplikasi online berbasis android salah satunya untuk digunakan sebagai media transaksi bisnisnya. UMKM surya jenangan merupakan salah satu pelaku bisnis dibidang perdagangan barang-barang kelontong yang masih menggunakan cara bisnis konvensional yaitu transaksi yang mensyaratkan antara penjual dan pembeli harus bertemu secara fisik untuk melakukan transaksi jual beli. Tujuan dari kegiatan pengabdian masyarakat ini adalah memberikan pelatihan dan implementasi menggunakan aplikasi berbasis android untuk meningkatkan omzet penjualan
Deconstructing the Dominant Human Rights Grammar: An Alter-Native Narrative based on Indigenous Peoples’ World-Views
Authors: Gómez-Sánchez Davinia 
Published: November 2022

This article contests the dominant ethnocentric Human Rights grammar and proposes a decentred alternative by focusing on the legal epistemologies of Southern African Indigenous Peoples. Increasing inequalities, aggravated poverty, environmental degradation, unsustainable life-styles and socio-cultural polarisation are compelling challenges that demand approaches grounded on new narratives, beyond the framework provided by Western centric theorisation, binary logic, the individual liberal human rights paradigm and neo-liberal development and justice models. The cultural specificity of human rights as well as their rise as normative instruments and assertions of universal entitlements, stripped human rights off the political and transformative potential to challenge the economic, social and political structures at the core of the imbalances they aim at remedying. In an attempt to transcend the limitations of the current hegemonic human rights paradigm (centred on the individual, rights and legalistic approaches), the proposal advanced here aims at reclaiming and recapturing the insights and values of African Indigenous Peoples as intellectual capital to reconfigure the prevailing human rights discourse. This article strives to rework and enlarge the notion and content of human rights with elements from counter hegemonic alternative world-views informed by peripheral knowledge(s), subaltern legalities and epistemologies. It seeks to revert epistemic injustice by formulating an alter-native narrative based on Indigenous Peoples’ world-views.
Optimization of experimental conditions of microbial desulfurization in coal mine using response surface methodology
Authors: Ai Chun‐ming , Sun Ping‐ping , Zhao Dan , Mu Xiao‐zhi 
Published: November 2022

To reduce the risk of spontaneous combustion during coal storage and transportation, microbial desulfurization technology is used to reduce the content of inorganic sulfur in coal. A strain of Aciditithiobacillus ferrooxidans was purified from coal mine water in Datong, Shanxi Province, and its desulfurization test conditions were optimized. Taking the inorganic sulfur removal rate of coal as the response value. The Plackett-Burman design method was used to screen the main factors affecting the response value. And the response surface method was used to establish the continuous variable surface model to determine the interaction between the factors. The results show that the three main factors affecting the response value and their significance order are temperature &gt; coal particle size &gt; desulfurization time, and the interaction between temperature and coal particle size has the greatest effect. When the temperature is 29.50°C, the coal size is 100 mesh, and the desulfurization time is 11.67 days, the desulfurization effect is the best, and the removal rate of inorganic sulfur can reach 79.78%, which is close to the predicted value, and the regression effect is wonderful.
Lava fountain jet noise during the 2018 eruption of fissure 8 of Kīlauea volcano
Authors: Gestrich Julia E. , Fee David , Matoza Robin S. , Lyons John J. , Dietterich Hannah R. , Cigala Valeria , Kueppers Ulrich , Patrick Matthew R. , Parcheta Carolyn E. 
Published: November 2022

Real-time monitoring is crucial to assess hazards and mitigate risks of sustained volcanic eruptions that last hours to months or more. Sustained eruptions have been shown to produce a low frequency (infrasonic) form of jet noise. We analyze the lava fountaining at fissure 8 during the 2018 Lower East Rift Zone eruption of Kīlauea volcano, Hawaii, and connect changes in fountain properties with recorded infrasound signals from an array about 500 m from the fountain using jet noise scaling laws and visual imagery. Video footage from the eruption reveals a change in lava fountain dynamics from a tall, distinct fountain at the beginning of June to a low fountain with a turbulent, out-pouring lava pond surrounded by a tephra cone by mid-June. During mid-June, the sound pressure level reaches a maximum, and peak frequency drops. We develop a model that uses jet noise scaling relationships to estimate changes in volcanic jet diameter and jet velocity from infrasound sound pressure levels and peak frequencies. The results of this model indicate a decrease in velocity in mid-June which coincides with the decrease in fountain height. Furthermore, the model results suggest an increase in jet diameter, which can be explained by the larger width of the fountain that resembles a turbulent lava pond compared to the distinct fountain at the beginning of June. The agreement between the infrasound-derived and visually observed changes in fountain dynamics suggests that jet noise scaling relationships can be used to monitor lava fountain dynamics using infrasound recordings.
Nonalcoholic fatty liver disease is specifically related to the risk of hepatocellular cancer but not extrahepatic malignancies
Authors: Albhaisi Somaya , McClish Donna , Kang Le , Gal Tamas , Sanyal Arun J. 
Published: November 2022

ObjectiveWe performed a matched cohort study among individuals with and without nonalcoholic fatty liver disease (NAFLD) to determine: 1) the incidence of cancers (extrahepatic and liver) and their spectrum and 2) if NAFLD increases the risk of extrahepatic cancers.MethodsThe NAFLD and non-NAFLD (control) cohorts were identified from electronic medical records via International Classification of Diseases (ICD) codes from a single center and followed from 2010 to 2019. Cohorts were matched 1:2 for age, sex, race, body mass index (BMI), and type 2 diabetes.ResultsA total of 1,412 subjects were included in the analyses. There were 477 individuals with NAFLD and 935 controls (median age, 52 years; women, 54%; white vs. black: 59% vs. 38%; median BMI, 30.4 kg/m2; type 2 diabetes, 34%). The cancer incidence (per 100,000 person-years) was 535 vs. 1,513 (NAFLD vs. control). Liver cancer incidence (per 100,000 person-years) was 89 in the NAFLD group vs. 0 in the control group, whereas the incidence of malignancy was higher across other types of cancer in the control group vs. in the NAFLD group.ConclusionsThe overall extrahepatic cancer risk in NAFLD is not increased above and beyond the risk from background risk factors such as age, race, sex, BMI, and type 2 diabetes.
Transcriptional mapping of the macaque retina and RPE-choroid reveals conserved inter-tissue transcription drivers and signaling pathways
Authors: Mungale Ameera , McGaughey David M. , Zhang Congxiao , Yousaf Sairah , Liu James , Brooks Brian P. , Maminishkis Arvydas , Fufa Temesgen D. , Hufnagel Robert B. 
Published: November 2022

The macula and fovea comprise a highly sensitive visual detection tissue that is susceptible to common disease processes like age-related macular degeneration (AMD). Our understanding of the molecular determinants of high acuity vision remains unclear, as few model organisms possess a human-like fovea. We explore transcription factor networks and receptor-ligand interactions to elucidate tissue interactions in the macula and peripheral retina and concomitant changes in the underlying retinal pigment epithelium (RPE)/choroid. Poly-A selected, 100 bp paired-end RNA-sequencing (RNA-seq) was performed across the macular/foveal, perimacular, and temporal peripheral regions of the neural retina and RPE/choroid tissues of four adult Rhesus macaque eyes to characterize region- and tissue-specific gene expression. RNA-seq reads were mapped to both the macaque and human genomes for maximum alignment and analyzed for differential expression and Gene Ontology (GO) enrichment. Comparison of the neural retina and RPE/choroid tissues indicated distinct, contiguously changing gene expression profiles from fovea through perimacula to periphery. Top GO enrichment of differentially expressed genes in the RPE/choroid included cell junction organization and epithelial cell development. Expression of transcriptional regulators and various disease-associated genes show distinct location-specific preference and retina-RPE/choroid tissue-tissue interactions. Regional gene expression changes in the macaque retina and RPE/choroid is greater than that found in previously published transcriptome analysis of the human retina and RPE/choroid. Further, conservation of human macula-specific transcription factor profiles and gene expression in macaque tissues suggest a conservation of programs required for retina and RPE/choroid function and disease susceptibility.
Mice with lung airway ciliopathy develop persistent Mycobacterium abscessus lung infection and have a proinflammatory lung phenotype associated with decreased T regulatory cells
Authors: Nava Audrey , Hahn Andrew C. , Wu Terry H. , Byrd Thomas F. 
Published: November 2022

IntroductionHuman pulmonary infection with non-tuberculous mycobacteria (NTM) such as Mycobacterium abscessus (Mabs) occurs in seemingly immunocompetent patients with underlying structural lung disease such as bronchiectasis in which normal ciliary function is perturbed. In addition to alterations in mucociliary clearance, the local immunologic milieu may be altered in patients with structural lung disease, but the nature of these changes and how they relate to NTM persistence remain unclear.MethodsWe used a mouse strain containing a conditional floxed allele of the gene IFT88, which encodes for the protein Polaris. Deletion of this gene in adult mice reportedly leads to loss of cilia on lung airway epithelium and to the development of bronchiectasis. In a series of experiments, IFT88 control mice and IFT88 KO mice received different preparations of Mabs lung inocula with lung CFU assessed out to approximately 8 weeks post-infection. In addition, cytokine levels in bronchoalveolar lavage (BAL) fluid, lung T cell subset analysis, and lung histopathology and morphometry were performed at various time points.ResultsMabs embedded in agarose beads persisted in the lungs of IFT88 KO mice out to approximately 8 weeks (54 days), while Mabs agarose beads in the lungs of IFT88 control mice was cleared from the lungs of all mice at this time point. T cells subset analysis showed a decrease in the percentage of CD4+FoxP3+ T cells in the total lymphocyte population in the lungs of IFT88 KO mice relative to IFT88 control mice. Proinflammatory cytokines were elevated in the BAL fluid from infected IFT88 KO mice compared to infected IFT88 control mice, and histopathology showed an increased inflammatory response and greater numbers of granulomas in the lungs of infected IFT88 KO mice compared to the lungs of infected IFT88 control mice. Scanning lung morphometry did not show a significant difference comparing lung airway area and lung airway perimeter between IFT88 KO mice and IFT88 control mice.DiscussionPersistent lung infection in our model was established using Mabs embedded in agarose beads. The utility of using IFT88 mice is that a significant difference in Mabs lung CFU is observed comparing IFT88 KO mice to IFT88 control mice thus allowing for studies assessing the mechanism(s) of Mabs lung persistence. Our finding of minimal differences in lung airway area and lung airway diameter comparing IFT88 KO mice to IFT88 control mice suggests that the development of a proinflammatory lung phenotype in IFT88 KO mice contributes to Mabs lung persistence independent of bronchiectasis. The contribution of cilia to immune regulation is increasingly recognized, and our results suggest that ciliopathy associated with structural lung disease may play a role in NTM pulmonary infection via alteration of the local immunologic lung milieu.