bluuebunny/crossref_metadata_2025_split huggingface dataset:
Excessive Blood Pressure Response to Clonidine in Hospitalized Patients With Asymptomatic Severe Hypertension
Authors: Hanna Jonathan , Ghazi Lama , Yamamoto Yu , Simonov Michael , Shah Tayyab , Wilson Francis P , Peixoto Aldo J 
Published: January 2022

Abstract

Background
There are limited and nonconcordant data on the rapidity and safety of blood pressure response to clonidine in the setting of asymptomatic severe hypertension. We evaluated the blood pressure response to clonidine in hospitalized patients with asymptomatic severe hypertension.

Methods
We performed a review of hospitalized, noncritically ill patients receiving clonidine within 6 hours of developing asymptomatic severe hypertension (systolic blood pressure [SBP] &gt;180 or diastolic blood pressure [DBP] &gt;110 mm Hg in the absence of acute hypertension-mediated target organ damage). The incidence of mean arterial pressure (MAP) reduction by ≥30% at 4 hours after clonidine was the primary endpoint.

Results
We identified 200 relevant patient encounters (median age 63 years, 48.5% women). Median time to clonidine following asymptomatic severe hypertension was 2.8 hours. A total of 20 (10%) patients had ≥30% MAP reduction within 4 hours after clonidine, and 32 (16%) patients had ≥30% reduction in either SBP, DBP, or MAP. Older age, female sex, and preexisting vascular disease were associated with ≥30% MAP reductions (P &lt; 0.05). Only patient sex and clonidine dose of 0.3 mg were significant in multivariable models. There were 14 adverse events observed within 24 hours of administration of clonidine; most (9) were acute kidney injury. There were no ischemic (myocardial, cerebrovascular) events.

Conclusions
A substantial minority of hospitalized patients with asymptomatic severe hypertension experience precipitous blood pressure decline with clonidine, and though blood pressure declines more precipitously in women and those receiving higher doses (0.3 mg specifically), the response to clonidine is generally not predictable on clinical grounds.
Predicting Out-of-Office Blood Pressure in a Diverse US Population
Authors: Bellows Brandon K , Xu Jingyu , Sheppard James P , Schwartz Joseph E , Shimbo Daichi , Muntner Paul , McManus Richard J , Moran Andrew E , Bryant Kelsey B , Cohen Laura P , Bress Adam P , King Jordan B , Shikany James M , Green Beverly B , Yano Yuichiro , Clark Donald , Zhang Yiyi 
Published: January 2022

AbstractBACKGROUNDThe PRedicting Out-of-OFfice Blood Pressure (PROOF-BP) algorithm accurately predicted out-of-office blood pressure (BP) among adults with suspected high BP in the United Kingdom and Canada. We tested the accuracy of PROOF-BP in a diverse US population and evaluated a newly developed US-specific algorithm (PROOF-BP-US).METHODSAdults with ≥2 office BP readings and ≥10 awake BP readings on 24-hour ambulatory BP monitoring from 4 pooled US studies were included. We compared mean awake BP with predicted out-of-office BP using PROOF-BP and PROOF-BP-US. Our primary outcomes were hypertensive out-of-office systolic BP (SBP) ≥130 mm Hg and diastolic BP (DBP) ≥80 mm Hg.RESULTSWe included 3,058 adults, mean (SD) age was 52.0 (11.9) years, 38% were male, and 54% were Black. The area under the receiver-operator characteristic (AUROC) curve (95% confidence interval) for hypertensive out-of-office SBP was 0.81 (0.79–0.82) and DBP was 0.76 (0.74–0.78) for PROOF-BP. For PROOF-BP-US, the AUROC curve for hypertensive out-of-office SBP was 0.82 (0.81–0.83) and for DBP was 0.81 (0.79–0.83). The optimal predicted out-of-office BP ranges for out-of-office BP measurement referral were 120–134/75–84 mm Hg for PROOF-BP and 125–134/75–84 mm Hg for PROOF-BP-US. The 2017 American College of Cardiology/American Heart Association BP guideline (referral range 130–159/80–99 mm Hg) would refer 93.1% of adults not taking antihypertensive medications with office BP ≥130/80 mm Hg in the National Health and Nutrition Examination Survey for out-of-office BP measurement, compared with 53.1% using PROOF-BP and 46.8% using PROOF-BP-US.CONCLUSIONSPROOF-BP and PROOF-BP-US accurately predicted out-of-office hypertension in a diverse sample of US adults.
Efficacy of Tranexamic Acid in Reducing Seroma and Hematoma Formation Following Reduction Mammaplasty
Authors: Weissler Jason M , Kuruoglu Doga , Antezana Luis , Curiel Daniel , Kerivan Lauren , Alsayed Ahmed , Banuelos Joseph , Harless Christin A , Sharaf Basel A , Vijayasekaran Aparna , Martinez-Jorge Jorys , Tran Nho V , Nguyen Minh-Doan T 
Published: January 2022

AbstractBackgroundTranexamic acid (TXA) has gained increasing recognition as a valuable pharmacologic agent within plastic surgery.ObjectivesThe aim of this study was to investigate the value and safety profile of both intravenous and topically administered TXA in the setting of bilateral reduction mammaplasty.MethodsA retrospective review was performed to identify consecutive patients who underwent bilateral reduction mammaplasty for symptomatic macromastia (January 2016-July 2021). Pertinent preoperative, intraoperative, and postoperative details were collected/reviewed. Primary outcome measures included hematoma requiring surgical evacuation and clinically significant/symptomatic seroma formation mandating percutaneous aspiration. Patients taking anticoagulation/antiplatelet medication or those with a history of thromboembolic diseases were excluded. Patients who had received TXA were compared to a historical control group who did not receive TXA within the same consecutive cohort.ResultsA total of 385 consecutive patients (770 breasts) were included. TXA was used in 514 (66.8%) cases (topical, 318 [61.9%]; intravenous, 170 [33.1%]; intravenous and topical, 26 [5.1%]). Neither seroma nor hematoma were impacted/reduced with TXA (P &gt; 0.05). Increased age (hazards ratio, 1.06 per 1-year increase; 95% CI, 1.004-1.118) significantly increased the risk of hematoma (P = 0.032). The use of drains significantly decreased the risk of seroma (P &lt; 0.0001). Increased BMI increased the risk of seroma (hazards ratio, 1.16 per 1-kg/m2 increase; 95% CI, 1.06-1.26; P = 0.0013). The use of TXA did not impact drain duration.ConclusionsThis study, the largest to date on the use of IV and topical TXA, did not find any reduction in risk when using TXA in breast reduction surgery.Level of Evidence: 3
Identifying drug–target interactions via heterogeneous graph attention networks combined with cross-modal similarities
Authors: Jiang Lu , Sun Jiahao , Wang Yue , Ning Qiao , Luo Na , Yin Minghao 
Published: January 2022

Abstract
Accurate identification of drug–target interactions (DTIs) plays a crucial role in drug discovery. Compared with traditional experimental methods that are labor-intensive and time-consuming, computational methods are more and more popular in recent years. Conventional computational methods almost simply view heterogeneous networks which integrate diverse drug-related and target-related dataset instead of fully exploring drug and target similarities. In this paper, we propose a new method, named DTIHNC, for $\mathbf{D}$rug–$\mathbf{T}$arget $\mathbf{I}$nteraction identification, which integrates $\mathbf{H}$eterogeneous $\mathbf{N}$etworks and $\mathbf{C}$ross-modal similarities calculated by relations between drugs, proteins, diseases and side effects. Firstly, the low-dimensional features of drugs, proteins, diseases and side effects are obtained from original features by a denoising autoencoder. Then, we construct a heterogeneous network across drug, protein, disease and side-effect nodes. In heterogeneous network, we exploit the heterogeneous graph attention operations to update the embedding of a node based on information in its 1-hop neighbors, and for multi-hop neighbor information, we propose random walk with restart aware graph attention to integrate more information through a larger neighborhood region. Next, we calculate cross-modal drug and protein similarities from cross-scale relations between drugs, proteins, diseases and side effects. Finally, a multiple-layer convolutional neural network deeply integrates similarity information of drugs and proteins with the embedding features obtained from heterogeneous graph attention network. Experiments have demonstrated its effectiveness and better performance than state-of-the-art methods. Datasets and a stand-alone package are provided on Github with website https://github.com/ningq669/DTIHNC.
BACPI: a bi-directional attention neural network for compound–protein interaction and binding affinity prediction
Authors: Li Min , Lu Zhangli , Wu Yifan , Li YaoHang 
Published: January 2022

AbstractMotivationThe identification of compound–protein interactions (CPIs) is an essential step in the process of drug discovery. The experimental determination of CPIs is known for a large amount of funds and time it consumes. Computational model has therefore become a promising and efficient alternative for predicting novel interactions between compounds and proteins on a large scale. Most supervised machine learning prediction models are approached as a binary classification problem, which aim to predict whether there is an interaction between the compound and the protein or not. However, CPI is not a simple binary on–off relationship, but a continuous value reflects how tightly the compound binds to a particular target protein, also called binding affinity.ResultsIn this study, we propose an end-to-end neural network model, called BACPI, to predict CPI and binding affinity. We employ graph attention network and convolutional neural network (CNN) to learn the representations of compounds and proteins and develop a bi-directional attention neural network model to integrate the representations. To evaluate the performance of BACPI, we use three CPI datasets and four binding affinity datasets in our experiments. The results show that, when predicting CPIs, BACPI significantly outperforms other available machine learning methods on both balanced and unbalanced datasets. This suggests that the end-to-end neural network model that predicts CPIs directly from low-level representations is more robust than traditional machine learning-based methods. And when predicting binding affinities, BACPI achieves higher performance on large datasets compared to other state-of-the-art deep learning methods. This comparison result suggests that the proposed method with bi-directional attention neural network can capture the important regions of compounds and proteins for binding affinity prediction.Availability and implementationData and source codes are available at https://github.com/CSUBioGroup/BACPI
The taxonomy of Leucanthemum ircutianum (Asteraceae, Anthemideae) in the Apennine Peninsula based on AFLP fingerprinting, plastid DNA sequence variation and eco-climatological niche reconstruction
Authors: Oberprieler Christoph , Conti Fabio , Dorfner Marco , Eder Sarah-Maria , Heuschneider Anja , Ott Tankred , Scheunert Agnes , Vogt Robert 
Published: January 2022

Abstract
The tetraploid species Leucanthemum ircutianum (Asteraceae, Anthemideae) is represented in the Apennine Peninsula by three infraspecific taxa, L. ircutianum subsp. ircutianum, L. ircutianum subsp. asperulum and L. ircutianum subsp. leucolepis. The present study uses AFLP fingerprinting and sequencing of the petN–psbM intergenic spacer (IGS) region of the plastid genome for inferring genetic relationships among these three subspecies and aims at the elaboration of an appropriate taxonomic treatment of these taxa. Due to the amphi-Adriatic distribution of these taxa, additional samples from the Balkan Peninsula and representatives of L. ircutianum subsp. ircutianum from north-western Italy, south-eastern France, Romania and southern Germany were included. Genetic analyses reveal that L. ircutianum subsp. asperulum from southern Italy and L. ircutianum subsp. leucolepis from the Balkan Peninsula and the northern and central Apennine Peninsula are identical and should be treated as a single taxon. The observation of genetically intermediate individuals throughout the overlapping distributional ranges of L. ircutianum subspp. ircutianum and leucolepis and in a surveyed mixed stand of the two taxa indicate that these are not reproductively isolated from each other. The analysis of eco-climatological niches of the two subspecies indicates that L. ircutianum subsp. ircutianum is found in more temperate regions, whereas L. ircutianum subsp. leucolepis prefers the Mediterranean fringe of the total distributional range of the species. A hybrid-zone analysis based on AFLP ‘allele frequency’ clines along a transect from Germany to southern Italy is interpreted as supporting a scenario of secondary contact of the two entities after some diversification in allopatry. On the basis of our results, we provide a taxonomic treatment of the species L. ircutianum for Italy, including the designation of three lectotypes.
Perceptual coupling and decoupling are associated with individual differences in working memory encoding and maintenance
Authors: Zhang Meichao , McNab Fiona , Smallwood Jonathan , Jefferies Elizabeth 
Published: January 2022

Abstract
Working memory (WM) allows goal-relevant information to be encoded and maintained in mind, even when the contents of WM are incongruent with the immediate environment. While regions of heteromodal cortex are important for WM, the neural mechanisms that relate to individual differences in the encoding and maintenance of goal-relevant information remain unclear. Here, we used behavioral correlates of two large-scale heteromodal networks at rest, the default mode (DMN) and frontoparietal (FPN) networks, to understand their contributions to distinct features of WM. We assessed each individual’s ability to resist distracting information during the encoding and maintenance phases of a visuospatial WM task. Individuals with stronger connectivity of DMN with medial visual and retrosplenial cortex were less affected by encoding distraction. Conversely, weaker connectivity of both DMN and FPN with visual regions was associated with better WM performance when target information was no longer in the environment and distractors were presented in the maintenance phase. Our study suggests that stronger coupling between heteromodal cortex and visual–spatial regions supports WM encoding by reducing the influence of concurrently presented distractors, while weaker visual coupling is associated with better maintenance of goal-relevant information because it relates to the capacity to ignore task-irrelevant changes in the environment.
Perioperative stroke and survival in coronary artery bypass grafting patients: a SWEDEHEART study
Authors: Jonsson Kristjan , Barbu Mikael , Nielsen Susanne J , Hafsteinsdottir Brynhildur , Gudbjartsson Tomas , Jensen Elin M , Silverborn Martin , Jeppsson Anders 
Published: January 2022

Abstract

OBJECTIVES
Perioperative stroke is a severe complication of cardiac surgery. We assessed the incidence of stroke over time, the association between stroke and mortality and identified preoperative factors independently associated with perioperative stroke, in a large nationwide cardiac surgery population.

METHODS
All patients who underwent coronary artery bypass grafting in Sweden 2006–2017 were included in a registry-based observational cohort study based on prospectively collected data. Multivariable logistic and Cox regression models were used to assess associations between perioperative stroke and mortality and to identify factors associated with stroke. The median follow-up was 6 years (range 0–12).

RESULTS
There were 441 perioperative strokes in 36 898 patients. The mean incidence was 1.2% and decreased marginally over time [adjusted odds ratio (OR) 0.97 per year (95% confidence interval 0.94–1.00), P = 0.035]. Stroke patients had a higher overall mortality risk during follow-up [adjusted hazard ratio 2.30 (2.00–2.64), P &lt; 0.001], with the highest risk during the first 30 postoperative days [adjusted hazard ratio (7.29 (5.58–9.54), P &lt; 0.001]. The strongest independent preoperative factors associated with stroke were prior cardiac surgery [adjusted OR 2.89 (1.40–5.96)], critical preoperative condition [adjusted OR 2.55 (1.73–3.76)], previous stroke [adjusted OR 1.77 (1.35–2.33)], preoperative angina requiring intravenous nitrates [adjusted OR 1.67 (1.28–2.17)], peripheral vascular disease [OR 1.63 (1.25–2.13)] and advanced age [OR 1.05 (1.03–1.06) per year].

CONCLUSIONS
The incidence of perioperative stroke after coronary artery bypass grafting has remained stable. Patients with perioperative stroke had a markedly higher adjusted risk of death early after surgery. The risk declined over time but remained higher during the entire follow-up period.
Caring Together: Trajectories of Paid and Family Caregiving Support to Those Living in the Community With Dementia
Authors: Reckrey Jennifer M , Li Lihua , Zhan Serena , Wolff Jennifer , Yee Cynthia , Ornstein Katherine A 
Published: January 2022

Abstract

Objectives
Paid caregivers (e.g., home health aides) often work with family caregivers to support persons living with dementia at home. We identify (a) unique trajectories of paid and family caregiving support among persons living with dementia with high care needs and (b) factors associated with these trajectories.

Methods
We used group-based multiple trajectory modeling to identify distinct trajectories of paid and family caregiving hours among National Health and Aging Trends Study respondents with dementia who died or moved to a nursing home (n = 334, mean follow-up 5.5 years). We examined differences between trajectory groups and identified factors associated with group membership using generalized estimating equation modeling.

Results
A 3-group model best fit our data: (a) “low/stable care” (61.3% of respondents) with stable, low/no paid care and moderate family care, (b) “increasing paid care” with increasing, moderate paid and family care, and (c) “high family care” with increasing, high family care and stable, low paid care. While both the “increasing paid care” and “high family care” groups were more functionally impaired than the “low/stable care” group, the “high family care” group was also more likely to be non-White and experience multiple medical comorbidities, depression, and social isolation.

Discussion
Study findings highlight the importance of considering unique arrangements in dementia care. Receipt of paid care was not only determined by patient care needs. Creating equitable access to paid care may be a particularly important way to support both persons living with dementia and their family caregivers as care needs grow.
Medical Cannabis and Utilization of Nonhospice Palliative Care Services: Complements and Alternatives at End of Life
Authors: Croker James A , Bobitt Julie , Arora Kanika , Kaskie Brian 
Published: January 2022

AbstractBackground and ObjectivesThere is a need to know more about cannabis use among terminally diagnosed older adults, specifically whether it operates as a complement or alternative to palliative care. The objective is to explore differences among the terminal illness population within the Illinois Medical Cannabis Program (IMCP) by their use of palliative care.Research Design and MethodsThe study uses primary, cross-sectional survey data from 708 terminally diagnosed patients, residing in Illinois, and enrolled in the IMCP. We compared the sample on palliative care utilization through logistic regression models, examined associations between palliative care and self-reported outcome improvements using ordinary least squares regressions, and explored differences in average pain levels using independent t-tests.Results115 of 708 terminally diagnosed IMCP participants were receiving palliative care. We find increased odds of palliative care utilization for cancer (odds ratio [OR] [SE] = 2.15 [0.53], p &lt; .01), low psychological well-being (OR [SE] = 1.97 [0.58], p &lt; .05), medical complexity (OR [SE] = 2.05 [0.70], p &lt; .05), and prior military service (OR [SE] = 2.01 [0.68], p &lt; .05). Palliative care utilization is positively associated with improvement ratings for pain (7.52 [3.41], p &lt; .05) and ability to manage health outcomes (8.29 [3.61], p &lt; .01). Concurrent use of cannabis and opioids is associated with higher pain levels at initiation of cannabis dosing (p &lt; .05).Discussion and ImplicationsOur results suggest that cannabis is largely an alternative to palliative care for terminal patients. For those in palliative care, it is a therapeutic complement used at higher levels of pain.
A novel Fontan Y-graft for interrupted inferior vena cava and azygos continuation
Authors: Lashkarinia S Samaneh , Cicek Murat , Kose Banu , Rezaeimoghaddam Mohammad , Yılmaz Emine Hekim , Aydemir Numan Ali , Rasooli Reza , Ozkok Sercin , Yurtseven Nurgul , Erdem Hasan , Pekkan Kerem , Sasmazel Ahmet 
Published: January 2022

Abstract

OBJECTIVES
To evaluate the hemodynamicdynamic advantage of a new Fontan surgical template that is intended for complex single-ventricle patients with interrupted inferior vena cava-azygos and hemi-azygos continuation. The new technique has emerged from a comprehensive pre-surgical simulation campaign conducted to facilitate a balanced hepatic flow and somatic Fontan pathway growth after Kawashima procedure.

METHODS
For 9 patients, aged 2 to18 years, majority having poor preoperative oxygen saturation, a pre-surgical computational fluid dynamics customization is conducted. Both the traditional Fontan pathways and the proposed novel Y-graft templates are considered. Numerical model was validated against in vivo phase-contrast magnetic resonance imaging data and in vitro experiments.

RESULTS
The proposed template is selected and executed for 6 out of the 9 patients based on its predicted superior hemodynamic performance. Pre-surgical simulations performed for this cohort indicated that flow from the hepatic veins (HEP) do not reach to the desired lung. The novel Y-graft template, customized via a right- or left-sided displacement of the total cavopulmonary connection anastomosis location resulted a drastic increase in HEP flow to the desired lung. Orientation of HEP to azygos direct shunt is found to be important as it can alter the flow pattern from 38% in the caudally located direct shunt to 3% in the cranial configuration with significantly reversed flow. The postoperative measurements prove that oxygen saturation increased significantly (P-value = 0.00009) to normal levels in 1 year follow-up.

CONCLUSIONS
The new Y-graft template, if customized for the individual patient, is a viable alternative to the traditional surgical pathways. This template addresses the competing hemodynamic design factors of low physiological venous pressure, high postoperative oxygen saturation, low energy loss and balanced hepatic growth factor distribution possibly assuring adequate lung development.

Date and number of IRB approval
25 October 2019, 280011928-604.01.01.
π1—smallDivisors and Fundamental Groups of Varieties
Authors: Hao Feng 
Published: January 2022

AbstractLasell and Ramachandran show that the existence of rational curves of positive self-intersection on a smooth projective surface $X$ implies that all the finite dimensional linear representations of the fundamental group $\pi _1(X)$ are finite. In this article, we generalize Lasell and Ramachandran’s result to the case of $\pi _1-small$ divisors on quasiprojective varieties. We also study $\pi _1-small$ curves and hyperbolicity properties of smooth projective surfaces of general type with infinite fundamental groups.