bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review on dry film photoresist-based patterning of Ag nanowire flexible electrodes for wearable electronics
Authors: Hwang Byungil , Matteini Paolo 
Published: September 2022

AbstractSilver (Ag) nanowires have attracted significant attention as flexible electrodes for various wearable electronic devices owing to their excellent optical and electrical properties. Patterning is an important step in the fabrication of Ag nanowire electrodes of appropriate size and shape for electronic device applications. Among the various methods to pattern Ag nanowires, photolithography using a liquid photoresist is the most widely used. However, some factors have limited an extensive use of this method, such as the non-uniform thickness of liquid photoresist on large-scale coatings and the requirement of a post-annealing step that limits the application to few polymeric substrates. In turn, these factors affect the successful application of the roll-to-roll fabrication process. Dry film photoresist (DFR), a solid-state film-type photoresist, can enable a fast and simple patterning process at lower temperatures, as DFR-based patterning process only requires a simple lamination step to coat the photoresist on the substrates. The DFR process is performed at a temperature below 80 °C, which enables the application of most polymeric substrates. Furthermore, this process doesn’t involve any additional post-annealing process, which makes it an appropriate technology for the roll-to-roll fabrication process. Owing to the advantages of DFR patterning, several recent studies have focused on this process for Ag nanowires patterning. This review provides an overview of successful examples of Ag nanowire patterning based on the use of DFR, along with the application of patterned Ag nanowires substrates as obtained by this method.
Associations of reproductive factors with postmenopausal follicle stimulating hormone
Authors: Costa Rebecca , Tuomainen Tomi-Pekka , Virtanen Jyrki , Niskanen Leo , Bertone-Johnson Elizabeth 
Published: September 2022

Abstract
Purpose
Recent studies have suggested that higher postmenopausal follicle stimulating hormone (FSH) may be associated with lower risk of diabetes. However, relatively little is known about postmenopausal FSH levels, including the level of variation between women and whether reproductive factors are associated with this variation.

Methods
We assessed the relationship of multiple reproductive factors with FSH levels among 588 postmenopausal women in the Kuopio Ischaemic Heart Disease Risk Factor Study. Participants were aged 53 to 73 years and not using hormone therapy at study enrollment (1998–2001) when reproductive factors were assessed and FSH was measured.

Results
After adjustment for age, menopause timing, sex steroid levels, adiposity and behavioral factors, we observed numbers of pregnancies and age at first birth were each inversely associated with FSH levels. For example, women with ≥ 3 births and an age at first birth ≥ 25 years had mean FSH levels that were 7.8 IU/L lower than those of women with 1–2 births and an age at first birth ≤ 24 years (P = 0.003). Number of miscarriages was inversely associated with FSH levels (-2.7 IU/L per miscarriage; P = 0.02). Women reporting 4 or more years of past hormone therapy use had significantly higher mean FSH levels than women who had never used hormone therapy (P for trend = 0.006).

Conclusion
Multiple reproductive factors were associated with postmenopausal FSH, independent of estradiol, adiposity and other confounders. These findings warrant replication and further exploration of potential underlying mechanism.
The Benefits of Resistance Training in Obese Adolescents: A Systematic Review and Meta-analysis
Authors: Ribeiro Bruno , Forte Pedro , Vinhas Raquel , Marinho Daniel A. , Faíl Luís B. , Pereira Ana , Vieira Fernando , Neiva Henrique P. 
Published: September 2022

Abstract
Background
Physical activity is essential in acquiring healthy lifestyle behaviors in the early years of maturational development and preventing various diseases. Resistance training (RT) is fundamental for improving body composition and is increasingly recommended for obese adolescents. A systematic review and meta-analysis were performed to synthesize and analyze data on the effects of RT programs in this population, seeking to develop useful recommendations for health and sports professionals.

Methods
A search was performed using four databases (Web of Science, Scopus, PubMed, and ScienceDirect). According to specific inclusion criteria, twenty-one studies were selected to evaluate the impact of RT on body mass index (BMI), body fat, waist circumference, muscle strength, insulin sensitivity, lean mass and cardiorespiratory fitness.

Results
After the RT programs, the adolescents improved their muscle strength (SMD, 1.44; 95% CI: 0.76–2.12), cardiorespiratory fitness (SMD, 1.09; 95% CI: 0.15–2.04), BMI (SMD, 0.21; 95% CI: 0.07–0.35), waist circumference (SMD, 0.27; 95% CI: 0.06–0.47) and body fat (SMD, 0.20; 95% CI: 0.05–0.34). However, insulin sensitivity (SMD, 0.32; 95% CI: − 0.47 to 1.10) and lean mass (SMD, 0.12; 95% CI: − 0.06 to 0.31) did not reveal any changes. Different RT programs were used but it seems that 2–3 times/week ∼60 min/session of RT for 12 weeks should be recommended for positive changes.

Conclusions
RT seems to be effective when the objective is to improve muscle strength, cardiorespiratory fitness and can be an efficient strategy to reduce obesity in adolescents by reducing body fat, waist circumference and body mass index.
PROSPERO Registration number: CRD42022333411.
What is the Effect of Changing Running Step Rate on Injury, Performance and Biomechanics? A Systematic Review and Meta-analysis
Authors: Anderson Laura M. , Martin Joel F. , Barton Christian J. , Bonanno Daniel R. 
Published: September 2022

Abstract
Background
Running-related injuries are prevalent among distance runners. Changing step rate is a commonly used running retraining strategy in the management and prevention of running-related injuries.

Objective
The aims of this review were to synthesise the evidence relating to the effects of changing running step rate on injury, performance and biomechanics.

Design
Systematic review and meta-analysis.

Data Sources
MEDLINE, EMBASE, CINAHL, and SPORTDiscus.

Results
Thirty-seven studies were included that related to injury (n = 2), performance (n = 5), and biomechanics (n = 36). Regarding injury, very limited evidence indicated that increasing running step rate is associated with improvements in pain (4 weeks: standard mean difference (SMD), 95% CI 2.68, 1.52 to 3.83; 12 weeks: 3.62, 2.24 to 4.99) and function (4 weeks: 2.31, 3.39 to 1.24); 12 weeks: 3.42, 4.75 to 2.09) in recreational runners with patellofemoral pain. Regarding performance, very limited evidence indicated that increasing step rate increases perceived exertion ( − 0.49,  − 0.91 to − 0.07) and awkwardness (− 0.72, − 1.38 to − 0.06) and effort (− 0.69, − 1.34, − 0.03); and very limited evidence that an increase in preferred step rate is associated with increased metabolic energy consumption (− 0.84, − 1.57 to − 0.11). Regarding biomechanics, increasing running step rate was associated with strong evidence of reduced peak knee flexion angle (0.66, 0.40 to 0.92); moderate evidence of reduced step length (0.93, 0.49 to 1.37), peak hip adduction (0.40, 0.11 to 0.69), and peak knee extensor moment (0.50, 0.18 to 0.81); moderate evidence of reduced foot strike angle (0.62, 034 to 0.90); limited evidence of reduced braking impulse (0.64, 0.29 to 1.00), peak hip flexion (0.42, 0.10 to 0.75), and peak patellofemoral joint stress (0.56, 0.07 to 1.05); and limited evidence of reduced negative hip (0.55, 0.20 to 0.91) and knee work (0.84, 0.48 to 1.20). Decreasing running step rate was associated with moderate evidence of increased step length (− 0.76, − 1.31 to − 0.21); limited evidence of increased contact time (− 0.95, − 1.49 to − 0.40), braking impulse (− 0.73, − 1.08 to − 0.37), and negative knee work (− 0.88, − 1.25 to − 0.52); and limited evidence of reduced negative ankle work (0.38, 0.03 to 0.73) and negative hip work (0.49, 0.07 to 0.91).

Conclusion
In general, increasing running step rate results in a reduction (or no change), and reducing step rate results in an increase (or no change), to kinetic, kinematic, and loading rate variables at the ankle, knee and hip. At present there is insufficient evidence to conclusively determine the effects of altering running step rate on injury and performance. As most studies included in this review investigated the immediate effects of changing running step rate, the longer-term effects remain largely unknown.

Prospero Registration

CRD42020167657.
Synergistic Effect of Increased Total Protein Intake and Strength Training on Muscle Strength: A Dose-Response Meta-analysis of Randomized Controlled Trials
Authors: Tagawa Ryoichi , Watanabe Daiki , Ito Kyoko , Otsuyama Takeru , Nakayama Kyosuke , Sanbongi Chiaki , Miyachi Motohiko 
Published: September 2022

Abstract
Background
Protein supplementation augments muscle strength gain during resistance training. Although some studies focus on the dose-response relationship of total protein intake to muscle mass or strength, the detailed dose-response relationship between total protein intake and muscle strength increase is yet to be clarified, especially in the absence of resistance training.

Objective
We aimed to assess the detailed dose-response relationship between protein supplementation and muscle strength, with and without resistance training.

Design
Systematic review with meta-analysis.

Data Sources
PubMed and Ichushi-Web (last accessed on March 23, 2022).

Eligibility Criteria
Randomized controlled trials investigating the effects of protein intake on muscle strength.

Synthesis Methods
A random-effects model and a spline model.

Results
A total of 82 articles were obtained for meta-analyses, and data from 69 articles were used to create spline curves. Muscle strength increase was significantly augmented only with resistance training (MD 2.01%, 95% CI 1.09–2.93) and was not augmented if resistance training was absent (MD 0.13%, 95% CI − 1.53 to 1.79). In the dose-response analysis using a spline model, muscle strength increase with resistance training showed a dose-dependent positive association with total protein intake, which is 0.72% (95% CI 0.40–1.04%) increase in muscle strength per 0.1 g/kg body weight [BW]/d increase in total protein intake up to 1.5 g/kg BW/d, but no further gains were observed thereafter.

Conclusion
Concurrent use of resistance training is essential for protein supplementation to improve muscle strength. This study indicates that 1.5 g/kg BW/d may be the most appropriate amount of total protein intake for maintaining and augmenting muscle strength along with resistance training.
Immunophenotyping of peripheral blood cells allows to discriminate MIS-C and Kawasaki disease
Authors: Castaldo Alice , D’Anna Carolina , Gelzo Monica , Giannattasio Antonietta , Maglione Marco , Muzzica Stefania , Raia Maddalena , Scalia Giulia , Tripodi Lorella , Castaldo Giuseppe , Tipo Vincenzo , Grieco Domenico , Grieco Michela 
Published: September 2022

Abstract
Background
The pathogenesis of the novel described multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD) is still debated as it is not clear if they are the same or different nosological entities. However, for both the diseases a rapid and unequivocal diagnosis is mandatory to start the therapy before the onset of severe complications. In this study, we aimed to evaluate the white cell populations in MIS-C and KD as potential markers to discriminate between the two diseases.

Methods
We studied white cell populations by flow cytometry in 46 MIS-C and 28 KD patients in comparison to 70 age-matched healthy children.

Results
MIS-C patients had a significant lymphopenia that involved both B and T populations while KD patients showed a significant neutrophilia and thrombocythemia. Granulocyte/lymphocyte ratio helped to diagnose both MIS-C and KD with a high diagnostic sensitivity, while a multivariate analysis of granulocyte and T lymphocyte number contributed to discriminate between the two diseases.

Conclusions
The relevant lymphopenia observed in MIS-C patients suggests that the disease would be a post-infectious sequel of COVID-19 immunologically amplified by a massive cytokine release, while the significant neutrophilia and thrombocythemia observed in KD confirmed that the disorder has the genesis of a systemic vasculitis. The analysis of a panel of circulating cells may help to early diagnose and to discriminate between the two diseases.
Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition
Authors: Kobayashi Miho , Fujiwara Kashio , Takahashi Kazuki , Yoshioka Yusuke , Ochiya Takahiro , Podyma-Inoue Katarzyna A. , Watabe Tetsuro 
Published: September 2022

Abstract
Background
During metastasis, cancer cells undergo epithelial-mesenchymal transition (EMT) in response to transforming growth factor-β (TGF-β), which is abundant in the tumor microenvironment, and acquire invasive and metastatic potentials. Metastasis to distant organs requires intravascular invasion and extravasation of cancer cells, which is accompanied by the disruption of the adhesion between vascular endothelial cells. Cancer cell-derived extracellular vesicles (EVs) have been suggested to induce the destabilization of normal blood vessels at the metastatic sites. However, the roles of EVs secreted from cancer cells that have undergone EMT in the destabilization of blood vessels remain to be elucidated. In the present study, we characterized EVs secreted by oral cancer cells undergoing TGF-β-induced EMT and elucidated their effects on the characteristics of vascular endothelial cells.

Methods
Induction of EMT by TGF-β in human oral cancer cells was assessed using quantitative RT-PCR (qRT-PCR) and immunocytochemistry. Oral cancer cell-derived EVs were isolated from the conditioned media of oral cancer cells that were treated with or without TGF-β using ultracentrifugation, and characterized using nanoparticle tracking analysis and immunoblotting. The effects of EVs on human umbilical artery endothelial cells were examined by qRT-PCR, cellular staining, and permeability assay. The significant differences between means were determined using a t-test or one-way analysis of variance with Tukey’s multiple comparisons test.

Results
Oral cancer cells underwent EMT in response to TGF-β as revealed by changes in the expression of epithelial and mesenchymal cell markers at both the RNA and protein levels. Oral cancer cells treated with TGF-β showed increased EV production and altered EV composition when compared with untreated cells. The EVs that originated from cells that underwent EMT by TGF-β induced endothelial-mesenchymal transition, which was characterized by the decreased and increased expression of endothelial and mesenchymal cell markers, respectively. EVs derived from oral cancer cells also induced intercellular gap formation which led to the loss of endothelial cell barrier stability.

Conclusions
EVs released from oral cancer cells that underwent TGF-β-induced EMT target endothelial cells to induce vascular destabilization. Detailed characterization of oral cancer-derived EVs and factors responsible for EV-mediated vascular instability will lead to the development of agents targeting metastasis.
Pilocytic astrocytoma of the cerebellopontine angle: a rare case
Authors: Bhradwaj Pranjal , Pandey Sharad , Kumar Pankaj , Gupta L. N. , Bharadwaj Minakshi 
Published: September 2022

Abstract
Background
Pilocytic astrocytomas are the most common primary brain tumors in children. Most of the lesions occur in or near the midline. They are rare in extra-axial locations.

Case presentation
We report a 23-year-old lady who was found to have progressive right-sided sensorineural hearing loss and features of raised intracranial pressure due to a pilocytic astrocytoma of the right cerebellopontine angle. After an extensive Medline search, we could find only three cases of primary extra-axial pilocytic astrocytoma of the cerebellopontine angle (CPA) reported till now.

Conclusion
Even a rare occurrence, primary pilocytic astrocytoma, and in general gliomas, should be kept in mind in the differential diagnosis of CPA lesions.
Post-traumatic stress disorder symptoms among nursing staff who provided direct care to COVID-19 patients: a cross-sectional study
Authors: Gabra Marina Adel , Mohammed Khaled Abd Elmoez , Hegazy Mohammed Nabil , Hendi Ahmed Elarabi 
Published: September 2022

Abstract
Background
The coronavirus disease 2019 (COVID-19) pandemic has led to a major physical and psychological burden on nursing staff who provide patient care in difficult circumstances with persistent exposure to infected patients. This study aimed to assess the prevalence of post-traumatic stress disorder (PTSD) symptoms among nursing staff working during the COVID-19 pandemic and its relationship with different work-related variables. It was designed as a cross-sectional comparative study in which 102 nurses on duty during the past 6 months were enrolled and divided into two groups. The first group included fifty-one COVID-dealing nurses who provided direct patient care to COVID-19 patients (emergency department, isolation zone, and intensive care unit (ICU)), while the second group included fifty-one non-COVID-dealing nurses on duty during the same period but in other hospital units and not providing direct care to COVID-19 patients (inpatient and outpatient wards).
Sociodemographic data, work-related variables, PTSD symptom severity, and diagnosis were all assessed.

Results
The COVID-dealing nurses had significantly less frequent short breaks (P = 0.007), inadequate organizational support and compensation (P = 0.024), and inadequate time off work (P = 0.004) compared to non-COVID-dealing nursing staff. They were also significantly suffering from PTSD compared to second-line staff (P = 0.025).

Conclusions
COVID-dealing nurses providing direct care to COVID-19 patients suffered significantly from PTSD with a variety of contributing work-related variables.
Soluble urokinase plasminogen activator receptor (suPAR) and glomerular disease in children: a narrative review
Authors: Le Thy Phuong Anh , Hoang Thi Thuy Yen , Tran Kiem Hao , Nguyen Huu Son 
Published: September 2022

Abstract
Background
Focal segmental glomerulosclerosis (FSGS) is a chronic glomerular disease that responds poorly to treatment, with a large proportion of patients progressing to end-stage renal disease in spite of initial aggressive treatment. It is worth emphasizing that the FSGS group has still a high recurrence rate after kidney transplantation. Therefore, understanding the factors involved in the pathogenesis of FSGS will help nephrologists better understand the pathogenesis as well as find out specific targeted therapies. Circulating immune factors have long been implicated in the pathogenesis of FSGS, and recent studies have suggested that soluble urokinase plasminogen activator receptor (suPAR) is one of the good candidates for this hypothesis. The aim of this review study was to analyze the value of suPAR in glomerular disease, especially in clinical studies.

Methods
In this review study, the PubMed database was searched using relevant keywords (suPAR, circulating permeability factors Children, FSGS, and children). Descriptive and cross-sectional studies were reviewed in the current study with the main focuses on the role of suPAR in FSGS, nephrotic syndrome, and the relation to progression of renal failure, especially the research in children.

Results
Overall, 32 studies from different countries were selected. These clinical studies on suPAR have shown the following: (i) the role of suPAR in the diagnosis of FSGS has not yet been confirmed, and (ii) there is strong evidence demonstrating a significant relationship between suPAR and the severity of kidney disease as well as a high value of suPAR in predicting the steroid responsiveness of nephrotic syndrome.

Conclusion
Researching on circulating permeability factors in FSGS is a current trend, which opens new avenues in targeted diagnosis and treatment. suPAR is a promising candidate, and urinary suPAR has also shown advantages over serum suPAR; therefore, more research on this issue is needed in the future.
Capitalization and profitability: applicability of capital theories in BRICS banking sector
Authors: Singhal Nikita , Goyal Shikha , Sharma Divya , Kumari Sapna , Nagar Shweta 
Published: September 2022

AbstractThe interrelationship between capitalization and profitability in banking sector of BRICS countries is studied with reference to existing five capital theories with the help of the ARDL and VECM/VAR models. These models are applied in the panel and individual settings on BRICS banking sector data from 2000 to 2020 to examine the presence of capital theories in the BRICS banking sectors. The study’s long-term empirical findings hold up the signalling and the bankruptcy cost hypothesis for the BRICS, Brazil, Russia, and India. Capitalization appears to be having a detrimental effect on profitability in China and South Africa, the agency argument is upheld. Profitability appears to have a considerable positive long-run influence on capitalization, which is consistent with Myers and Majluf’s (J Financ Econ 13:187–221, 1984) pecking order model for BRICS and Brazil. Profitability has a detrimental influence on capitalization in India and South Africa, corroborating the Modigliani and Miller (Am Econ Rev 48:261–297, 1958) and Miller (J Financ 32:1151–1168, 1977) notion. Although least significance is observed in most circumstances, the results of short-term prediction are comparable to those of long-run estimation. Both short-run and long-run evaluations of the capital-profitability link help in designing the “macroprudential” policies that demonstrate significance of our research.
Using a pilot-centric, qualitative drug risk assessment model to identify opportunities for implementing pharmacogenetics
Authors: Kinard Jeffrey L. , Collie Jacob , Turner Clesson , Chapleau Richard R. 
Published: September 2022

Abstract
Background
Risk assessment models are at the core of flight medicine, weighing both the impact of the flight environment on an aviator and the potential impact of medical events in aviators on flight operations. Pharmacogenetics is the application of a patient’s genetic information to reduce medication risk. Here, we use three medical conditions commonly encountered by the U.S. Air Force’s flight medicine community (asthma, diabetes, and hypertension) to demonstrate a framework for implementing occupationally relevant pharmacogenetics. We identified medications approved by the U.S. Food & Drug Administration for each condition, obtained adverse effects and frequencies, scored each adverse effect’s impact on work duties from 0 to 4 in increasing severity, and used control theory to stratify the medications by occupational risk. For those medications within 10% of the control limits, pharmacogenetic information was collected from PharmGKb.

Results
We observed a correlation of 0.557 between our risk scores and previous reports for 20 medications, demonstrating robustness of our scoring. Using average risks for those 20 medications, we set control theory acceptable and tolerable thresholds at 601,109.5 and 2,097,721, respectively. The majority of medications for the three conditions were below the thresholds (66 and 26, respectively). Three medications have pharmacogenetic guidance provided by regulatory bodies.

Conclusions
By focusing first on risk to performing occupational tasks and then on genetic implementation, our work presents a framework by which pharmacogenetics can be selectively applied by considering specific occupational and environmental risks, thereby saving costs and reducing possible psychological burdens on patients.