bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prefabricated contoured foot orthoses to reduce pain and increase physical activity in people with hip osteoarthritis: protocol for a randomised feasibility trial
Authors: King Matthew G , Kemp Joanne L , Hon Ryan , Pizzari Tania , Wong Justin , Menz Hylton , Taylor Nicholas F , Harms Anton , McClelland Jodie A , Semciw Adam Ivan 
Published: September 2022

IntroductionThe aim of this randomised feasibility trial is to determine the feasibility of conducting an adequately powered randomised controlled trial (RCT) investigating the efficacy of prefabricated contoured foot orthoses in people with hip osteoarthritis (OA). The secondary aims of the trial are to compare the effect of prefabricated contoured foot orthoses to a flat shoe insert comparator on outcomes of hip-related pain, physical activity and quality of life. We hypothesise that the demand, implementation, acceptability and practicality of foot orthoses as a treatment option for people with hip OA will be deemed feasible, informing the development of an adequately powered RCT to evaluate the efficacy and long term outcomes.Methods and analysisWe will recruit 28 people with hip OA who will be randomised to receive either prefabricated contoured foot orthoses or flat shoe inserts to use for a 6-week period. Both groups will receive standardised education on hip OA and physical activity. The study’s primary outcome is the feasibility domains of demand, implementation, acceptability and practicality. The secondary outcomes include the change in Hip Osteoarthritis Outcome Score-12, Patient Health Questionnaire-9, Brief Fear of Movement Scale for OA, Physical activity accelerometry and the Physical Activity Questionnaire-short form. Descriptive statistics will be used to describe feasibility outcomes with limited efficacy analysis used for the secondary outcomes. Linear mixed models will be used to analyse between-group differences at 6 weeks, with baseline values used as covariates, treatment allocation as a fixed factor and participant as a random factor.Ethics and disseminationThis trial has been approved by the La Trobe University Human Research Ethics Committee (HEC20427), St. Vincent’s Hospital Melbourne, Human Research Ethics Committee (HREC 266/20) and Northern Health Research Governance (NH-2021-292862). The results will be disseminated via a peer-reviewed journal and presented at international conferences.Trial registration numberNCT05138380.
Independent reporting in oral and maxillofacial pathology
Authors: Gorania Riddhi , Hunter Keith , Hall Gillian , Brierley Daniel J 
Published: September 2022

AimsTo understand the current practice, extent of use and barriers related to independent reporting (IR) in oral and maxillofacial pathology (OMFP) training in the UK.MethodsA questionnaire was created containing questions about the experiences and opinions surrounding IR in OMFP. The target participants were (1) consultants in OMFP who had been involved in training OMFP trainees in the last 5 years and (2) current OMFP trainees. The questionnaire was delivered via Google Forms and disseminated using a link in an invitation email sent to the participants.ResultsA total of 13 consultant responses (response rate of 81%) and 12 trainee responses (response rate of 92%) were received. Of these, three consultants and five trainees were using IR at the time of the study. Several themes emerged highlighting the perceived benefits and concerns regarding IR.ConclusionsThis study suggests that there is a disparity in the way IR is used in OMFP training across the UK. There was shared concern between consultants and trainees regarding the lack of clear guidance and subsequent fear of litigation. These are issues that need to be addressed if trainees are to have a similar experience across the country and be prepared for independent practice on completion of training.
Perceived discrimination at work: examining social, health and work-related factors as determinants among breast cancer survivors – evidence from the prospective CANTO cohort
Authors: Ruiz De Azua Garazi , Vaz-Luis Ines , Bovagnet Thomas , Di Meglio Antonio , Havas Julie , Caumette Elsa , Martin Elise , Pistilli Barbara , Coutant Charles , Cottu Paul , Rouanet Philippe , Arnaud Antoine , Arsene Olivier , Ibrahim Mahmoud , Wassermann Johanna , Rouzier Roman , Martin Anne-Laure , Everhard Sibille , Dumas Agnes , Menvielle Gwenn 
Published: September 2022

BackgroundWe assessed the prevalence of self-reported perceived discrimination in the workplace after the end of treatment among breast cancer (BC) survivors and studied its association with social, health-related and work-related factors.MethodsWe used data from a French prospective cohort (CANcer TOxicities) including women diagnosed with stage I–III BC. Our analysis included 2130 women who were employed, <57 years old at BC diagnosis and were working 2 years afterwards. We assessed the association between social, health-related and work-related factors and perceived discrimination in the workplace using logistic regression models.ResultsOverall, 26% of women reported perceived discrimination in the workplace after the end of treatment. Women working for a small company, in the public sector or with better overall health status were less likely to report perceived discrimination. Women who benefited from easing dispositions at their workplace, who did not feel supported by their colleagues and those who returned to work because of fear of job loss were more likely to report perceived discrimination.ConclusionsOne in four BC survivors perceives discrimination in the workplace. Health and work-related factors are associated with increased likelihood of reporting perceived discrimination.Trial registration numberNCT01993498.
Defining capabilities in deployed UK military prehospital emergency care
Authors: Thompson Michael , Jefferson O , James T , Waller B , Reed R , Slade H , Swift K , Pynn H J 
Published: September 2022

The UK military prehospital emergency care (PHEC) operational clinical capability framework must be updated in order that it retains its use as a valid operational planning tool. Specific requirements include accurately defining the PHEC levels and the ‘Medical Emergency Response Team’ (MERT), while reinforcing PHEC as a specialist area of clinical practice that requires an assured set of competencies at all levels and mandatory clinical currency for vocational providers.A military PHEC review panel was convened by the Defence Consultant Advisor (DCA) for PHEC. Each PHEC level was reviewed and all issues which had, or could have arisen from the existing framework were discussed until agreement between the six members of this panel was established.An updated military PHEC framework has been produced by DCA PHEC, which defines the minimum requirements for each operational PHEC level. These definitions cover all PHEC providers, irrespective of professional background. The mandatory requirement for appropriate clinical exposure for vocational and specialist providers is emphasised. An updated definition of MERT has been agreed.This update provides clarity to the continually evolving domain of UK military PHEC. It sets out the PHEC provider requirements in order to be considered operationally deployable in a PHEC role. There are implications for training, manning and recruitment to meet these requirements, but the processes required to address these are already underway and well described elsewhere.
Association of fluid-attenuated inversion recovery vascular hyperintensity with ischaemic events in internal carotid artery or middle cerebral artery occlusion
Authors: Lyu Jinhao , Hu Jianxing , Wang Xinrui , Bian Xiangbing , Wei Mengting , Wang Liuxian , Duan Qi , Lan Yina , Zhang Dekang , Wang Xueyang , Zhang Tingyang , Tian Chenglin , Lou Xin 
Published: September 2022

Background and purposeIndividuals with intracranial artery occlusion have high rates of ischaemic events and recurrence. It has been challenging to identify patients who had high-risk stroke using a simple, valid and non-invasive screening approach. This study aimed to investigate whether fluid-attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH), a specific imaging sign on the FLAIR sequence, could be a predictor of ischaemic events in a population with internal carotid artery (ICA) or middle cerebral artery (MCA) occlusion.MethodsWe retrospectively analysed 147 patients (mean 60.43±12.83 years) with 149 lesions, including 37 asymptomatic and 112 symptomatic cases of ICA or MCA occlusion. Symptomatic occlusion was considered if ischaemic events were present in the relevant territory within 90 days. FVH Alberta Stroke Program Early Computed Tomography Score (FVH-ASPECTS: 0–7, with 0 indicating absence of FVH and 7 suggesting prominent FVH) and collateral circulation grade were assessed for each participant. Multivariable logistic regression analysis was performed to detect independent markers associated with symptomatic status.ResultsA lower FVH-ASPECTS was associated with a more favourable collateral circulation grade (rho=−0.464, p<0.0001). The FVH-ASPECTS was significantly lower in the asymptomatic occlusion group than in the symptomatic occlusion group (p<0.0001). FVH-ASPECTS (Odd ratio, 2.973; 95% confidence interval, 1.849 to 4.781; p<0.0001) was independently associated with symptomatic status after adjustment for age, sex, lesion location and collateral circulation grade in the multivariate logistic regression. The area under the curve was 0.861 for the use of FVH-ASPECTS to identify symptomatic occlusion.ConclusionsThe ability to discriminate symptomatic from asymptomatic occlusion suggests that FVH may be a predictor of stroke. As a simple imaging sign, FVH may serve as a surrogate for haemodynamic impairments and can be used to identify high-risk stroke cases early in ICA or MCA occlusion.
Frameworks for generalized anisotropic conformally flat polytropes in f(R) gravity
Authors: Mardan S. A. , Amjad Zargona , Noureen I. 
Published: September 2022

AbstractThe purpose of this paper is to analyze the conformally flat spherically symmetric fluid distribution with generalized polytropic equations of state. We have developed two different framework for two different definitions of generalized polytropes. The frameworks for development of modified Lane–Emden equation are presented for both cases. The conformally flat condition is used to calculate anisotropy factor which transform considered systems into consistent systems. Tolman mass function is used in the polytropic models to check their stability.
A quantum segmentation algorithm based on local adaptive threshold for NEQR image
Authors: Wang Lu , Liu Wenjie 
Published: September 2022

The classical image segmentation algorithm based on local adaptive threshold can effectively segment images with uneven illumination, but with the increase of the image data, the real-time problem gradually emerges. In this paper, a quantum segmentation algorithm based on local adaptive threshold for NEQR image is proposed, which can use quantum mechanism to simultaneously compute local thresholds for all pixels in a gray-scale image and quickly segment the image into a binary image. In addition, several quantum circuit units, including median calculation, quantum binarization, etc. are designed in detail, and then a complete quantum circuit is designed to segment NEQR images by using fewer qubits and quantum gates. For a [Formula: see text] image with [Formula: see text] gray-scale levels, the complexity of our algorithm can be reduced to O[Formula: see text], which is an exponential speedup compared to the classic counterparts. Finally, the experiment is conducted on IBM Q to show the feasibility of our algorithm in the noisy intermediate-scale quantum (NISQ) era.
Multi-linear regression of triple diffusive convectively heated boundary layer flow with suction and injection: Lie group transformations
Authors: Mamatha S. U. , Devi R. L. V. Renuka , Ahammad N. Ameer , Shah Nehad Ali , Rao B. Madhusudhan , Raju C. S. K. , Khan M. Ijaz , Guedri Kamel 
Published: September 2022

This work analyzes the two-dimensional flow of an incompressible magneto-hydrodynamic fluid over linear stretching sheet in the presence of suction or injection and convective boundary conditions. A scaling group transformation method is applied to the flow governing equations. The system remains invariant due to the relation between the transformation parameters. Upon finding three absolute invariants, third-order ordinary differential equations (ODEs) corresponding to momentum equation and second-order ODEs corresponding to energy and diffusion equations are derived. Shooting technique (R-K fourth-order) is applied to work out the flow equations numerically. MATLAB is used for the simulation and the results are exhibited through graphs. The computational results are validated with the published research work and a modest concurrence was found. The main outcome of this study is found to be that raising values of [Formula: see text] and [Formula: see text] decline the friction, whereas [Formula: see text] and [Formula: see text] show the opposite (increasing). The rising values of [Formula: see text] and [Formula: see text] in addition to [Formula: see text] and [Formula: see text] show a decline in friction factor. The Nusselt number values are improved as raising values of [Formula: see text] versus [Formula: see text] and [Formula: see text] versus [Formula: see text]. It is very clear the monotonically increasing [Formula: see text] versus [Formula: see text] and strictly increasing [Formula: see text] versus [Formula: see text] cases. It is very clear the mass-transfer rate is smoothly improved [Formula: see text] versus [Formula: see text] and strictly increased [Formula: see text] versus [Formula: see text].
HMGN5 Escorts Oncogenic STAT3 Signaling by Regulating the Chromatin Landscape in Breast Cancer Tumorigenesis
Authors: Mou Jiahui , Huang Meijun , Wang Feifei , Xu Xiaoding , Xie Hanqi , Lu Henglei , Li Mingyang , Li Yu , Kong Weiwen , Chen Jing , Xiao Ying , Chen Yiding , Wang Chaochen , Ren Jin 
Published: September 2022

Abstract

Cancer progression is highly dependent on the ability of cancer cell tumor formation, in which epigenetic modulation plays an essential role. However, the epigenetic factors promoting breast tumor formation are less known. Screened from three-dimensional (3D)-sphere tumor formation model, HMGN5 that regulates chromatin structures became the candidate therapeutic target in breast cancer, though its role is obscure. HMGN5 is highly expressed in 3D-spheres of breast cancer cells and clinical tumors, also an unfavorable prognostic marker in patients. Furthermore, HMGN5 controls tumor formation and metastasis of breast cancer cells in vitro and in vivo. Mechanistically, HMGN5 is governed by active STAT3 transcriptionally and further escorts STAT3 to shape the oncogenic chromatin landscape and transcriptional program. More importantly, interference of HMGN5 by nanovehicle-packaged siRNA effectively inhibits tumor growth in breast cancer cell–derived xenograft mice model.

Implications:
Our findings reveal a novel feed-forward circuit between HMGN5 and STAT3 in promoting breast cancer tumorigenesis and suggest HMGN5 as a novel epigenetic therapeutic target in STAT3-hyperactive breast cancer.
Abstract IA25: Human genetic studies: CLL and transformation
Authors: Wu Catherine J 
Published: September 2022

Abstract
Across cancers, histologic transformation remains a major challenge due to its association with rapid tumor progression and resistance. This is well-exemplified by Richter syndrome (RS) – the occurrence of an aggressive lymphoma of dismal prognosis in patients with chronic lymphocytic leukemia (CLL). RS is now a major obstacle to long-term CLL cure since the targeted agents developed for CLL have failed to either prevent or treat RS. In short, RS is becoming a frequent mode of progression and escape through therapeutic resistance. Thus far, definitive evolutionary studies and understanding of the genomic basis of transformation have yet to be completed. Major challenges towards this goal include the very fact that patient biopsy specimens contain an admixture of both CLL and RS tumor cells within the same tumor microenvironment, thereby limiting reliable investigations of RS cells. For CLL, large-scale sequencing studies have successfully demonstrated the diverse spectrum of recurrent gene mutations associated with CLL and the high level of genetic heterogeneity amongst patient samples, consistent with the high degree of clinical variability that is characteristic of this malignancy. We will review new studies to integrate multiple data layers in a cohort of &gt;1000 patients, providing us with a ‘CLL map.’ Recently, we have been developing highly novel analytics that allow us to discern, within a sample that is admixed with both CLL and RS cells, the contributions of CLL vs that of RS. In doing so, we are able to identify new drivers and molecular subtypes of RS, and profile the trajectory from CLL to RS. Such studies are paradigm shifting for the clinic in relationship to both detection, diagnosis and prognosis of RS, and advances our efforts to attain a molecular definition of RS. Moreover, the methodologies, conclusions and detailed studies presented in our work are highly relevant to other hematologic malignancies and solid tumors.
Citation Format: Catherine J Wu. Human genetic studies: CLL and transformation [abstract]. In: Proceedings of the Third AACR International Meeting: Advances in Malignant Lymphoma: Maximizing the Basic-Translational Interface for Clinical Application; 2022 Jun 23-26; Boston, MA. Philadelphia (PA): AACR; Blood Cancer Discov 2022;3(5_Suppl):Abstract nr IA25.
Clinical Diagnosis of Probable Cerebral Amyloid Angiopathy: Diagnostic Accuracy Meta-Analysis of the Boston Criteria
Authors: Charidimou Andreas , Boulouis Gregoire 
Published: September 2022

Background:
The Boston criteria are used widely for the noninvasive diagnosis of sporadic cerebral amyloid angiopathy (CAA) and hence clinical decision-making, as well as research in the field. Yet, their exact diagnostic accuracy and validity remain (paradoxically) poorly studied. We performed a meta-analysis to synthesize evidence on the value and accuracy of the Boston criteria in diagnosing probable CAA patients.

Methods:
In a systematic literature search, we identified studies with extractable data relevant for sensitivity and specificity of probable CAA diagnosis per the magnetic resonance imaging Boston criteria and neuropathological CAA verification. We included studies that have classified patients according to any version of the Boston criteria, based on available brain magnetic resonance imaging blood-sensitive sequences (index test) and had neuropathologic evaluation for CAA presence from brain tissue samples (diagnostic reference standard). Using a hierarchical (multilevel) logistic regression model, we calculated pooled diagnostic test accuracy for probable CAA diagnosis.

Results:
Seven studies, including 193 patients, 121 with neuropathologically verified CAA versus 72 non-CAA based on neuropathology definition, were included in the meta-analysis. The studies were of low-to-moderate quality and varied in several methodological aspects. The overall pooled sensitivity for probable CAA diagnosis was 66.7% (95% CI, 45.9%–82.6%) and specificity was 88.2% (95% CI, 68.5%–96.3%). A predefined subgroup analysis of 4 studies on Boston criteria v.1.0 (n=151) demonstrated a pooled sensitivity and specificity of 60% (95% CI, 45.1%–72.9%) and 93.1% (95% CI, 81.8%–97.6%), respectively. Five studies had data on Boston criteria v.1.5 (n=123): the pooled sensitivity and specificity for probable CAA diagnosis was 73.1% (95% CI, 45%–90.1%) and 86% (95% CI, 41.4%–98.1%), respectively.

Conclusions:
The Boston criteria v.1.0 and v.1.5 appear to have moderate-to-good diagnostic accuracy for probable CAA in symptomatic patients, with high specificity but low-to-moderate sensitivity. Data are based on limited retrospective studies of overall low quality and at high risk of bias.
A Survey on Automated Fact-Checking
Authors: Guo Zhijiang , Schlichtkrull Michael , Vlachos Andreas 
Published: September 2022

Abstract
Fact-checking has become increasingly important due to the speed with which both information and misinformation can spread in the modern media ecosystem. Therefore, researchers have been exploring how fact-checking can be automated, using techniques based on natural language processing, machine learning, knowledge representation, and databases to automatically predict the veracity of claims. In this paper, we survey automated fact-checking stemming from natural language processing, and discuss its connections to related tasks and disciplines. In this process, we present an overview of existing datasets and models, aiming to unify the various definitions given and identify common concepts. Finally, we highlight challenges for future research.
Animal Abuse and Bullying/Victimization in a Community Sample of School-Age Children
Authors: Andreou Eleni , Vasiou Aikaterini , Xafakos Efstathios , Korona Aikaterini 
Published: September 2022

Abstract
In recent years school bullying and other forms of aggressive behaviors in children and adolescents have become an issue of great concern among parents, psychologists, and educators. This study examined the relationship between school bullying and animal abuse in a community sample of school-age children. One hundred and seventy-four elementary school students from central Greece participated in the study and filled in self-report questionnaires which examined animal abuse, bullying – victimization, empathy, self-control, and peer interactions. Results showed that bullying behavior and peer victimization are associated with both direct abuse of animals and witnessing violence against animals. Multiple regression analysis indicated that witnessing animal abuse and being victimized by peers are positive predictors of bullying. Empathy, self-control, and peer interactions failed to predict school bullying. We discuss theoretical mechanisms linking bullying/victimization and animal abuse as well as directions for future research.