bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gambaran Kejadian Ikutan Pasca Imunisasi (KIPI) Setelah Melakukan Vaksinasi Covid-19 Pada Masyarakat Banjarmasin Selatan
Authors: Kurniawati Darini , Yuwindry Iwan , Sariyasih Sariyasih 
Published: December 2022

Latar Belakang : Covid-19 menyerang saluran pernapasan yang muncul pertama kali pada bulan Desember 2019 di Kota Wuhan, Provinsi Hubei, Cina. World Health Organization (WHO) menyatakan sebagai pandemi global sejak 11 Maret 2020. Program vaksinasi covid-19 di Indonesia telah dimulai pada 13 Januari 2021. Vaskinasi covid-19 dapat menyebabkan terjadinya Kejadian Ikutan Pasca Imunisasi (KIPI) yang dapat ditandai dengan gejala ringan hingga berat. Tujuan : Mengetahui bagaimana Kejadian Ikutan Pasca Imunisasi (KIPI) pada masyarakat Banjarmasin selatan setelah melakukan vaksinasi Covid-19. Metode : Penelitian ini merupakan penelitian kuantitatif observasional dengan jenis penelitian deskriptif, penelitian ini hanya mendeskripsikan suatu objek penelitian, maka data penelitian yang diperoleh berupa angka akan dikualitatifkan sehingga hasil yang diperoleh dapat dideskriptifkan. Penelitian ini dilakukan menggunakan algoritma naranjo yang dibagikan kepada masyarakat dan di input melalui Google Form. Hasil : Penelitian ini menunjukan sebanyak 37 responden dengan persentasi laki-laki 51% dan perempuan 49% diperoleh hasil skor 4-8 yaitu “kemungkinan Besar Terjasi ROM” yaitu dengan jumlah 13 responden, yang menggunakan vaksin sinovac pada 11 responden dan ada sebanyak 2 moderna responden. kemudian dengan skor 1-3 yaitu “Kemungkinan terjadi ROM” dengan jumlah 23 responden yang menggunakan vaksin sinovac. Kemudian dengan skor 0 yaitu “diragukan terjadi ROM” ada sebanyak 1 responden denan vaksin sinovac. Dari kedua vaksin tersebut yaitu pada vaksin Sinovac memiliki efektivitas sebesar 56-65% sedangkan Vaksin Moderna memiliki efektivitas 94,1%. Adapun efek samping umum pada vaksin sinovac seperti nyeri suntikan, demam, kelelahan, sedangkan efek samping pada vaksin moderna paling umum terjadi adalah demam, nyeri pada suntikan, sakit kepala, dan mual. Simpulan : Kejadian Ikutan Pasca Imunisasi (KIPI) responden yang melakukan vaksinasi covid-19 sebanyak 23 reponden kategori Possible, 13 responden kategori Probable, dan 1 responden kategori Doubtful.
Pengaruh Perbedaan Jenis Pelarut Terhadap Kadar Fenolik Ekstrak Daun Sirsak (Annona Muricata L.)
Authors: Listiawati Maria Dwi Ayu , Nastiti Kunti , Audina Mia 
Published: December 2022

Latar belakang: Daun Sirsak (Annona muricata L.) dimanfaatkan sebagai obat antikanker oleh masyarakat karena daun sirsak memiliki kandungan senyawa fenolik yang tinggi yang mempunyai aktivitas antoksidan yang dapat menangkal radikal bebas penyebab kanker. Senyawa fenolik memiliki sifat yang polar sehingga untuk memperoleh senyawa ini digunakan pelarut polar yang sama yakni etanol 70%, etanol 96% dan Metanol dimana penggunaan jenis pelarut yang berbeda akan mempengaruhi kadar fenolik yang dihasilkan.
Tujuan: Mengetahui berapakah kadar dan pengaruh perbedaan kadar fenolik daun sirsak (Annona Muricata L.) berdasarkan perbedaan jenis pelarut polar.
Metode: Penelitian ini menggunakan metode pre-eksperimental dengan rancangan acak random dengan melakukan metode ekstraksi maserasi lalu dilakukan uji Kromatografi Lapis Tipis untuk diidentifikasi senyawa fenolik. Kemudian penentuan Kadar fenolik total menggunakan spektrofotometri UV-Vis.
Hasil: Pengaruh perbedaan jenis pelarut dari kadar fenolik dengan uji parametrik One Way Annova. Kadar fenolik total daun sirsak ekstrak Etanol 70%, Etanol 96% dan Metanol yang diperoleh adalah 5,753 mg GAE/g, 4,022 mg GAE/g dan 7,179 mg GAE/g.
Kesimpulan: Perbedaan Jenis pelarut berpengaruh signifikan 0,000 (p<0,05) terhadap kadar fenolik ekstrak daun sirsak.Hasil penelitian disimpulkan metanol efektif menyari senyawa fenolik dibandingkan etanol 70% dan etanol 96%.
Wastewater bacteria remediating the pharmaceutical metformin: Genomes, plasmids and products
Authors: Martinez-Vaz Betsy M. , Dodge Anthony G. , Lucero Rachael M. , Stockbridge Randy B. , Robinson Ashley A. , Tassoulas Lambros J. , Wackett Lawrence P. 
Published: December 2022

Metformin is used globally to treat type II diabetes, has demonstrated anti-ageing and COVID mitigation effects and is a major anthropogenic pollutant to be bioremediated by wastewater treatment plants (WWTPs). Metformin is not adsorbed well by activated carbon and toxic N-chloro derivatives can form in chlorinated water. Most earlier studies on metformin biodegradation have used wastewater consortia and details of the genomes, relevant genes, metabolic products, and potential for horizontal gene transfer are lacking. Here, two metformin-biodegrading bacteria from a WWTP were isolated and their biodegradation characterized. Aminobacter sp. MET metabolized metformin stoichiometrically to guanylurea, an intermediate known to accumulate in some environments including WWTPs. Pseudomonasmendocina MET completely metabolized metformin and utilized all the nitrogen atoms for growth. Pseudomonas mendocina MET also metabolized metformin breakdown products sometimes observed in WWTPs: 1-N-methylbiguanide, biguanide, guanylurea, and guanidine. The genome of each bacterium was obtained. Genes involved in the transport of guanylurea in Aminobacter sp. MET were expressed heterologously and shown to serve as an antiporter to expel the toxic guanidinium compound. A novel guanylurea hydrolase enzyme was identified in Pseudomonas mendocina MET, purified, and characterized. The Aminobacter and Pseudomonas each contained one plasmid of 160 kb and 90 kb, respectively. In total, these studies are significant for the bioremediation of a major pollutant in WWTPs today.
Sustained therapeutic effect of an anti-inflammatory peptide encapsulated in nanoparticles on ocular vascular leakage in diabetic retinopathy
Authors: Qu Qiang , Park Kyoungmin , Zhou Kevin , Wassel Drew , Farjo Rafal , Criswell Tracy , Ma Jian-xing , Zhang Yuanyuan 
Published: December 2022

Pigment epithelium-derived factor (PEDF), an endogenous Wnt signaling inhibitor in the serine proteinase inhibitors (SERPIN) super family, is present in multiple organs, including the vitreous. Significantly low levels of PEDF in the vitreous are found to associate with pathological retinal vascular leakage and inflammation in diabetic retinopathy (DR). Intravitreal delivery of PEDF represents a promising therapeutic approach for DR. However, PEDF has a short half-life after intravitreal injection, which represents a major hurdle for the long-term treatment. Here we report the prolonged therapeutic effects of a 34-mer peptide of the PEDF N-terminus, encapsulated in poly (lactic-co-glycolic acid) (PLGA) nanoparticles (PEDF34-NP), on DR. PEDF34-NP inhibited hypoxia-induced expression of vascular endothelial growth factor and reduced levels of intercellular adhesion molecule 1 (ICAM-1) in cultured retinal cells. In addition, PEDF34-NP significantly ameliorated ischemia-induced retinal neovascularization in the oxygen-induced retinopathy rat model, and significantly reduced retinal vascular leakage and inflammation in streptozotocin-induced diabetic rats up to 4 weeks after intravitreal injection, as compared to PLGA-NP control. Intravitreal injection of PEDF34-NP did not display any detectable toxicities to retinal structure and function. Our findings suggest that PEDF34-NP can confer sustained therapeutic effects on retinal inflammation and vascular leakage, having considerable potential to provide long-term treatment options for DR.
Mapping of Tilapia Lake Virus entry pathways with inhibitors reveals dependence on dynamin activity and cholesterol but not endosomal acidification
Authors: Abu Rass Reem , Kembou-Ringert Japhette Esther , Zamostiano Rachel , Eldar Avi , Ehrlich Marcelo , Bacharach Eran 
Published: December 2022

Tilapia Lake Virus (TiLV) is an emerging virus lethal to tilapia, which threatens the global tilapia aquaculture with severe implications for food security. TiLV possesses similar features to orthomyxoviruses but is classified in the sole and the monotypic genus Tilapinevirus of the family Amnoonviridae. TiLV enveloped virions encapsidate a genome comprising ten segments of single-stranded, negative RNA. Remarkably, nine of TiLV’s ten major proteins lack sequence homology to any known viral or cellular proteins. The mode of TiLV entry into tilapia cells is not known. Following the measurement of the entry window of TiLV (∼3 h), we applied a panel of inhibitors of known regulators of endocytic functions to map the molecular requirements for TiLV entry. We identified productive entry by quantification of TiLV nucleoprotein expression and the generation of infectious particles. Inhibition of dynamin activity with dynasore or dynole, or depletion of cholesterol with methyl-β-cyclodextrin, strongly inhibited TiLV protein synthesis and infectious virion production. Moreover, inhibition of actin cytoskeleton polymerization with latrunculin A or microtubule polymerization with nocodazole within the entry window resulted in partial inhibition of TiLV infection. In contrast, inhibitors of endosomal acidification (NH4Cl, bafilomycin A1, or chloroquine), an inhibitor of clathrin-coated pit assembly (pitstop 2), and erlotinib—an inhibitor of the endocytic Cyclin G-associated kinase (GAK), did not affect TiLV entry. Altogether, these results suggest that TiLV enters via dynamin-mediated endocytosis in a cholesterol-, cytoskeleton-dependent manner, and clathrin-, pH-independent manner. Thus, despite being an orthomyxo-like virus, when compared to the prototypical orthomyxovirus (influenza A virus), TiLV shows a distinct set of requirements for entry into cells.
Forecasting fund-related textual emotion trends on Weibo: A time series study
Authors: Luo Sha 
Published: December 2022

IntroductionThis paper reports a time series analysis of day-to-day emotional text related to fund investments on Weibo (Sina Corporation, Beijing, China).MethodsThe present study employed web-crawler and text mining techniques through Python to obtain data from January 1, 2021 to December 31, 2021.ResultsUsing an auto-regressive integrated moving average model and vector auto-regressive model, the results indicated that fund performance was a significant predictor of fear, anger, and surprise expressions on Weibo. A relationship among emotions within a certain single fund was not found, but textual emotions could be predicted by ARIMA models within emotions.DiscussionThe findings provide insight for media emotion analysis combining linguistic and temporal dimensions in both the communication and psychology disciplines.
Left atrial shortening fraction to predict fetal cardiac abnormalities and dysfunction in gestational diabetes mellitus
Authors: Peng Yu-Qing , Qiu Xuan , Wang Li , Li Xin , Huo Xiao-Yan 
Published: December 2022

ObjectiveTo evaluate the diagnostic efficiency of left atrial shortening fraction (LASF) in the detection of fetal cardiac abnormalities and dysfunction in patients with gestational diabetes mellitus (GDM).MethodsIn this study, we enrolled 256 pregnant women and divided them into GDM group (n = 156) and control group (n = 100). Fetal echocardiography was performed at 24–28 weeks of gestation to measure the LASF and interventricular septum (IVS) thickness. Based on IVS thickness, the GDM group was subdivided into the septal hypertrophy group (GDM I, n = 62) and non-septal hypertrophy group (GDM II, n = 94). LASF and IVS thickness were compared between the GDM and control groups and between GDM I and GDM II groups. Receiver operating characteristic (ROC) analysis was performed to determine the diagnostic accuracy of LASF in predicting septal hypertrophy.ResultsThe GDM group had a larger IVS thickness (P &lt; 0.05) but a lower LASF level (P &lt; 0.001) than those of the control group. GDM I group had significantly lower LASF level than that in the GDM II group (P &lt; 0.001). At 38.41% as the cutoff value, the LASF can predict septal hypertrophy with diagnostic sensitivity and specificity of 96.7% and 65.2%, respectively.ConclusionFetal GDM are more likely to induce septal hypertrophy and ventricular dysfunction. LASF is a good indicator of septal hypertrophy or early diastolic dysfunction without septal hypertrophy.
Why are children absent from preschool? A nationally representative analysis of Head Start programs
Authors: Purtell Kelly M. , Ansari Arya 
Published: December 2022

IntroductionChildren who are absent from school, including preschool, do not make the same academic gains as their non-absent peers. However, we know little about what predicts absenteeism among preschool-attending children.MethodsWe used the Family and Child Experiences Study - 2009, a nationally representative sample of Head Start attendees (n = 2,842), to test the associations between a comprehensive set of child, family, and center factors, and children’s levels of absenteeism across the preschool year.ResultsOur findings highlight the multi-faceted nature of absenteeism. Family necessity, family routines, and center-level characteristics were all associated with absenteeism.DiscussionReducing preschool absenteeism requires a comprehensive approach as the factors that shape absences are varied. Our findings suggest that center-level strategies focused on outreach and classroom quality are important future directions.
Diabetes health coach in individuals with type 2 diabetes: A systematic review and meta analysis of quadruple aim outcomes
Authors: Racey Megan , Jovkovic Milos , Alliston Paige , Ali Muhammad Usman , Sherifali Diana 
Published: December 2022

BackgroundAs diabetes self-management necessitates life-long learning, behaviour change, support, and monitoring, health coaching is a promising intervention to assist individuals in more than just meeting glycemic goals and glycated hemoglobin (A1C) targets. Currently, studies of health coaching for type 2 diabetes (T2DM) are limited due to their emphasis on glycemic control. The goal of this systematic review and meta-analysis is to determine the effects of health coaching on adults with T2DM based on quadruple aim outcomes and to assess the implementation of these interventions.MethodsWe searched 6 databases for randomized controlled trials of health coaching interventions delivered by a health professional for adults with T2DM. Reviewers screened citations, extracted data, and assessed risk of bias and certainty of evidence (GRADE). We assessed statistical and methodological heterogeneity and performed a meta−analysis of studies.ResultsNine studies were included in this review. Our meta-analysis showed a significant reduction of A1C [0.24 (95% CI, -0.38 to -0.09)] after exposure to diabetes health coaching, and small to trivial significant benefits for BMI, waist circumference, body weight, and depression/distress immediately post intervention based on moderate certainty of evidence. However, long term benefit of these clinical outcomes were not maintained at follow-up timepoints. There was a small significant benefit for systolic blood pressure which was maintained after the completion of health coaching exposure at follow-up, but there was no statistically significant benefit in other secondary outcomes such as diastolic blood pressure and lipid profile measures (e.g. triglycerides). Very few studies reported on other quadruple aim measures such as patient-reported outcomes, cost of care, and healthcare provider experience.ConclusionsOur systematic review and meta-analysis shows that health coaching interventions can have short term impact beyond glucose control on cardiometabolic and mental health outcomes. Future studies should try to examine quadruple aim outcomes to better assess the benefit and impact of these interventions at longer time points and following termination of the coaching program.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero, identifier (CRD42022347478).
Double-edged sword of diabetes mellitus for abdominal aortic aneurysm
Authors: Huang Zijia , Su Huiling , Zhang Tiejun , Li Yuwen 
Published: December 2022

IntroductionDiabetes mellitus (DM) has been proved to contribute to multiple comorbidities that are risk factors for abdominal aortic aneurysm (AAA). Remarkably, evidences from epidemiologic studies have demonstrated a negative association between the two disease states. On the other hand, hyperglycemic state was linked to post-operative morbidities following AAA repair. This review aims to provide a thorough picture on the double-edged nature of DM and major hypoglycemic medications on prevalence, growth rate and rupture of AAA, as well as DM-associated prognosis post AAA repair.MethodsWe performed a comprehensive search in electronic databases to look for literatures demonstrating the association between DM and AAA. The primary focus of the literature search was on the impact of DM on the morbidity, enlargement and rupture rate, as well as post-operative complications of AAA. The role of antidiabetic medications was also explored.ResultsRetrospective epidemiological studies and large database researches associated the presence of DM with decreased prevalence, slower expansion and limited rupture rate of AAA. Major hypoglycemic drugs exert similar protective effect as DM against AAA by targeting pathological hallmarks involved in AAA formation and progression, which were demonstrated predominantly by animal studies. Nevertheless, presence of DM or postoperative hyperglycemia was linked to poorer short-term and long-term prognosis, primarily due to greater risk of infection, longer duration of hospital stays and death.ConclusionWhile DM is a positive factor in the formation and progression of AAA, it is also associated with higher risk of negative outcomes following AAA repair. Concomitant use of antidiabetic medications may contribute to the protective mechanism of DM in AAA, but further studies are still warranted to explore their role following AAA repair.
Single or double headed capsules for the investigation of suspected small bowel bleeding: Are two heads better than one
Authors: McCarthy Eilis , Sihag Sandeep , Deane Charlene , Walker Caroline , Semenov Serhiy , Ryan Barbara , Breslin Niall , O’Connor Anthony , O’Donnell Sarah , McNamara Deirdre 
Published: December 2022

BackgroundCapsule endoscopy is now the accepted first line investigation for suspected small bowel (SB) bleeding. Recent evidence suggests the diagnostic yield for SB pathology may be higher for tailored double headed (DH) SB capsules. Whether other forms of bidirectional capsules offer a similar advantage is less clear.AimTo compare the efficacy of single headed versus bidirectional capsules in detecting pathology in patients with suspected small bowel bleeding.MethodsA single centre prospective comparison study was conducted over an 8 month period in a tertiary care hospital. Patients referred with overt or suspected SB bleeding were assigned to either SB3 Medtronic SB capsule (SH) during the initial four months or PillCam Colon 2 Medtronic capsule (DH) during the subsequent four months. Studies were analysed by trained Capsule Endoscopists and approved by our institutions capsule review board. Findings were compared between SH and DH capsules using a chi2 or t-test as appropriate. A p value of &lt;0.05 was considered significant.Results201 subjects were included, mean age 61.8 years, 90 (45%) male. Majority referred with occult bleeding, 153 (76%). DH and SH capsule used in 100 and 101 cases, respectively. 90% (n=181) capsules were complete and overall diagnostic yield was 57% (n=114). Diagnostic yield was similar between both groups - DH 53% (n=53), SH 60% (n=61). Positive finding in overt bleeding; SH 85% (n=22) versus DH 50% (n=11), p&lt;0.02. SH capsules more frequently detected SB inflammation, 27 (27%) versus 9 (9%), p&lt;0.002. More patients had another diagnosis in the DH (19) than the SH (9), p&lt;0.04, the majority were type 1a vascular lesions, “red spots” or diminutive colonic polyps.ConclusionSingle head and double head capsules perform similary in terms of diagnostic yield overall. This supports the continued use of standard small bowel capsules for investigation of the small bowel.
Risk profile of postnatal women and their babies attending a rural district hospital in South Africa
Authors: Rees Kate , Mutyambizi Chipo , Ndou Rendani , Struthers Helen E , McIntyre James A , Dunlop Jackie 
Published: December 2022

BackgroundMaternal and neonatal mortality remain unacceptably high and inequitably distributed in South Africa, with the postnatal period being a dangerous time for both mother and baby. The aim of this paper is to describe the risk factors for poor postnatal outcomes, including postnatal mental health disorders, in a population of postnatal women and their babies utilising rural district hospital services in Limpopo Province, with a focus on HIV. We also describe health care provider compliance with relevant guidelines.MethodsAll women discharged from the postnatal ward of the district hospital who consented to participate were enrolled. A research nurse used a structured questionnaire to collect data about sociodemographic information, pregnancy and pre-existing conditions, complications during labour and birth, pregnancy outcomes and mental health risk factors.ResultsThe questionnaire was completed for 882 women at the time of discharge. Only 354 (40.2%) of participants had completed secondary education, and 105 (11.9%) reported formal employment. Chronic hypertension was recorded in 20 women (2.3%), with an additional 49 (5.6%) developing a hypertensive disorder during pregnancy. HIV prevalence was 22.8%. 216 women (24.5%) had a mental health risk factor, with 40 reporting more than one (4.5%). Having no income, no antenatal care, having HIV and any hypertensive disorder were significantly associated with a positive mental health risk screen in multivariable analysis. There were 31 stillbirths and early neonatal deaths (3.5%), and 119 babies (13.4%) were born at a low birth weight. Stillbirth or early neonatal death was significantly associated with no antenatal care in multivariable analysis.ConclusionsWomen and babies in this study experienced multiple risk factors for poor outcomes in the postpartum period. Postnatal care should be strengthened in order to address the dominant risks to mothers and babies, including socioeconomic challenges, HIV and hypertension, and risks to mental health. Tools to identify mothers and babies at risk of postnatal complications would allow limited resources to be allocated where they are most needed.