bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal Associations Between Timing of Physical Activity Accumulation and Health: Application of Functional Data Methods
Authors: Lin Wenyi , Zou Jingjing , Di Chongzhi , Sears Dorothy D. , Rock Cheryl L. , Natarajan Loki 
Published: September 2022

AbstractAccelerometers are widely used for tracking human movement and provide minute-level (or even 30 Hz level) physical activity (PA) records for detailed analysis. Instead of using day-level summary statistics to assess these densely sampled inputs, we implement functional principal component analysis (FPCA) approaches to study the temporal patterns of PA data from 245 overweight/obese women at three visits over a 1-year period. We apply longitudinal FPCA to decompose PA inputs, incorporating subject-specific variability, and then test the association between these patterns and obesity-related health outcomes by multiple mixed effect regression models. With the proposed methods, the longitudinal patterns in both densely sampled inputs and scalar outcomes are investigated and connected. The results show that the health outcomes are strongly associated with PA variation, in both subject and visit-level. In addition, we reveal that timing of PA during the day can impact changes in outcomes, a finding that would not be possible with day-level PA summaries. Thus, our findings imply that the use of longitudinal FPCA can elucidate temporal patterns of multiple levels of PA inputs. Furthermore, the exploration of the relationship between PA patterns and health outcomes can be useful for establishing weight-loss guidelines.
Antimicrobial Properties, Functional Characterisation and Application of Fructobacillus fructosus and Lactiplantibacillus plantarum Isolated from Artisanal Honey
Authors: De Simone Nicola , Rocchetti Maria Teresa , la Gatta Barbara , Spano Giuseppe , Drider Djamel , Capozzi Vittorio , Russo Pasquale , Fiocco Daniela 
Published: September 2022

AbstractHoney is a valuable reservoir of lactic acid bacteria (LAB) and, particularly, of fructophilic LAB (FLAB), a relatively novel subgroup of LAB whose functional potential for human and food application has yet to be explored. In this study, FLAB and LAB strains have been isolated from honeys of different floral origins and selected for their broad antimicrobial activity against typical foodborne pathogenic bacteria and spoilage filamentous fungi. The best candidates, two strains belonging to the species Lactiplantibacillus plantarum and Fructobacillus fructosus, were submitted to partial characterisation of their cell free supernatants (CFS) in order to identify the secreted metabolites with antimicrobial activity. Besides, these strains were examined to assess some major functional features, including in vitro tolerance to the oro-gastrointestinal conditions, potential cytotoxicity against HT-29 cells, adhesion to human enterocyte-like cells and capability to stimulate macrophages. Moreover, when the tested strains were applied on table grapes artificially contaminated with pathogenic bacteria or filamentous fungi, they showed a good ability to antagonise the growth of undesired microbes, as well as to survive on the fruit surface at a concentration that is recommended to develop a probiotic effect. In conclusion, both LAB and FLAB honey-isolated strains characterised in this work exhibit functional properties that validate their potential use as biocontrol agents and for the design of novel functional foods. We reported antimicrobial activity, cytotoxic evaluation, probiotic properties and direct food application of a F. fructosus strain, improving the knowledge of this species, in particular, and on FLAB, more generally.
Encapsulation of Bifidobacterium animalis subsp. lactis Through Emulsification Coupled with External Gelation for the Development of Synbiotic Systems
Authors: Frakolaki Georgia , Giannou Virginia , Tzia Constantina 
Published: September 2022

AbstractAim of this work was the development of integrated and complex encapsulating systems that will provide more efficient protection to the probiotic strain Bifidobacterium animalis subsp. lactis (BB-12) in comparison to the conventional plain alginate beads. Within the scope of this study, the encapsulation of BB-12 through emulsification followed by external gelation was performed. For this purpose, a variety of alginate-based blends, composed of conventional and novel materials, were used. The results demonstrated that alginate beads incorporating 1% carrageenan or 2% nanocrystalline cellulose provided great protection to the viability of the probiotic bacteria during refrigerated storage (survival rates of 50.3% and 51.1%, respectively), as well as in vitro simulation of the gastrointestinal tract (survival rates of 38.7 and 42.0%, respectively). The incorporation of glycerol into the formulation of the beads improved the protective efficiency of the beads to the BB-12 cells during frozen storage, increasing significantly their viability compared to the plain alginate beads. Beads made of milk, alginate 1%, glucose 5%, and inulin 2% provided the best results in all cases. The microstructure of beads was assessed through SEM analysis and showed absence of free bacteria on the surface of the produced beads. Consequently, the encapsulation of BB-12 through emulsification in a complex encapsulating system was proved successful and effective.
AI-driven lightweight real-time SDR sensing system for anomalous respiration identification using ensemble learning
Authors: Saeed Umer , Abbasi Qammer H. , Shah Syed Aziz 
Published: September 2022

AbstractIn less than three years, more than six million fatalities have been reported worldwide due to the coronavirus pandemic. COVID-19 has been contained within a broad range due to restrictions and effective vaccinations. However, there is a greater risk of pandemics in the future, which can cause similar circumstances as the coronavirus. One of the most serious symptoms of coronavirus is rapid respiration decline that can lead to mortality in a short period. This situation, along with other respiratory conditions such as asthma and pneumonia, can be fatal. Such a condition requires a reliable, intelligent, and secure system that is not only contactless but also lightweight to be executed in real-time. Wireless sensing technology is the ultimate solution for modern healthcare systems as it eliminates close interactions with infected individuals. In this paper, a lightweight real-time solution for anomalous respiration identification is provided using the radio-frequency sensing device USRP and the ensemble learning approach extra-trees. A wireless software-defined radio platform is used to acquire human respiration data based on the change in the channel state information. To improve the performance of the trained models, the respiration data is utilised to produce large simulated data sets using the curve fitting technique. The final data set consists of eight distinct types of respiration: eupnea, bradypnea, tachypnea, sighing, biot, Cheyne-stokes, Kussmaul, and central sleep apnea. The ensemble learning approach: extra-trees are trained, validated, and tested. The results showed that the proposed platform is lightweight and highly accurate in identifying several respirations in a static setting.
An Alternative Option for Gender-Affirming Revision Vaginoplasty: The Tubularized Urachus-Peritoneal Hinge Flap
Authors: Smith Shannon M. , Yuan Nance , Stelmar Jenna , PA-C Grace Lee , Gupta Amit , Kim Hyung L. , Garcia Maurice M. 
Published: September 2022

AbstractIntroductionGender-affirming peritoneal vaginoplasty has been described, and previous descriptions are modifications of the Davydov technique.AimTo describe our alternative technique for gender-affirming peritoneal vaginoplasty (PV) using a single-pedicled, urachus-peritoneal hinge flap, discussing proposed advantages.MethodsRetrospective review of all consecutive transfeminine patients with neovaginal shortening after prior penile inversion vaginoplasty (PIV) who underwent our PV technique from May 2019 to July 2022. PV was performed via combined transperineal and laparoscopic (robot-assisted) approaches. After spatulation of the neovaginal remnant, a midline, inferiorly based urachus-peritoneal hinge flap was elevated craniocaudally from the umbilicus to the mid-posterior bladder. The free end of the flap was flipped posteriorly and sutured to posterior edge of the open canal remnant, forming a peritoneal pouch. The lateral edges of the pouch were sutured together for water-tight closure. Patients resumed dilation on POD 6 and douching on POD 10.Main Outcome MeasuresTen transfeminine patients underwent PV, with good outcomes. We measured: Pre-op penile and scrotal skin lengths, intra-op tubularized scrotal skin length, pre and post-op vaginal depth and width (immediate and at last follow-up).ResultsPre-op: mean neovaginal depth was 9.2cm (SD 1.5); width was 12cm. Immediate post-op: mean depth was 15.1 cm (SD 2.2 cm, mean net increase: 5.9 cm). At mean follow-up of 18.3 months, mean depth was 12.5 cm (SD 2.1 cm, mean net increase: 3.3 cm) and width was 12 cm. There were no immediate post-op complications. Eight (80%) of the 10 patients report satisfactory vaginal receptive intercourse. The other 2 have not yet attempted vaginal receptive intercourse.Clinical ImplicationsAdvantages of the proposed technique over existing techniques include no tension on peritoneal suture lines and total exclusion of the rectum.Strengths and LimitationsStrengths include a short learning curve for urologic surgeons with robotic experience. The study is limited by small sample size.ConclusionsOur PV technique is a safe and effective option for salvage peritoneal vaginoplasty after primary PIV.
Comparing human to electronic observers to monitor hand hygiene compliance in an intensive care unit
Authors: Casaroto Eduardo , Generoso Jose R. , Serpa Neto Ary , Prado Marcelo , Gagliardi Guilherme M. , de Menezes Fernando Gatti , Gonçalves Priscila , Hohmann Fábio Barlem , Olivato Guilherme Benfatti , Gonçalves Gustavo Potratz , Xavier Nathalia , Fernandes Miguel Marcelo , Edmond Michael B. , Marra Alexandre R. 
Published: September 2022

Abstract

Objective:
We sought to determine whether an electronic hand hygiene (HH) system could monitor HH compliance at similar rates to direct human observation.

Methods:
This 4-year proof-of-concept study was conducted in an intensive care unit (ICU) of a private tertiary-care hospital in São Paulo, Brazil, where electronic HH systems were installed in 2 rooms. HH compliance was reported respectively using direct observation and electronic counter devices with an infrared system for detecting HH opportunities.

Results:
In phase 1, HH compliance by human observers was 56.3% (564 of 1,001 opportunities), while HH compliance detected by the electronic observer was 51.0% (515 of 1,010 opportunities). In phase 2, human observers registered 484 HH opportunities with a HH compliance rate of 64.7% (313 of 484) versus 70.6% (346 of 490) simultaneously detected by the electronic system. In addition, an enhanced HH electronic system monitored activity 24 hours per day and HH compliance without the presence of a human observer was 40.3% (10,642 of 26,421 opportunities), providing evidence for the Hawthorne effect.

Conclusions:
The electronic HH monitoring system had good correlation with human HH observation, but compliance was remarkably lower when human observers were not present due to the Hawthorne effect (25%–30% absolute difference). Electronic monitoring systems can replace direct observation and can markedly reduce the Hawthorne effect.
Expanding Access to Naloxone: A Necessary Step to Curb the Opioid Epidemic
Authors: Houser Ryan 
Published: September 2022

Abstract
The COVID-19 Pandemic has exacerbated the already worsening opioid epidemic within the United States. With a continuing increase in opioid overdose deaths, measures are needed to halt the needless number of deaths and begin on a path of recovery to address all the factors that impact the epidemic. The CDC has provided various recommendations to combat the increases in opioid overdose deaths. These recommendations have included expanded distribution and use of naloxone and overdose prevention education as essential services for people most at risk of overdose. While strategies should include the increase in community resources for those with opioid disorder and shifting the perspectives of healthcare to view opioid disorder as a chronic illness that can be treated with medication such as buprenorphine, these methods are not immediate enough to stop the trend in deaths. The United States must take immediate action to expand access to and use of Naloxone for the public and first responders. Naloxone alone cannot address the magnitude of this epidemic, but it is an essential first step in preventing immediate death while a multimodal strategy is enacted to fully protect those most at risk.
Historical Scholarship and Training at Ife: Growth, Personalities, and Professorships, 1962–2022
Authors: Amusa Saheed B. , Adesoji Abimbola O. 
Published: September 2022

AbstractThis paper is the first part of a detailed historical assessment of historical scholarship and training at the Department of History of the Obafemi Awolowo University, Ile-Ife. It examines the growth and development of the Department since the inception of the University in 1962. It discusses the pioneer academic staff of the Department and subsequent people that taught in the Department over the years. The paper shows that the Department of History at Ife has excelled in all areas of historical scholarship over the years and that its professors and other scholars have contributed immensely to the reconstruction of African past. This is done through brief but succinct profiling of the professors and their professorial inaugural lectures as well as other scholars affiliated with the Department. The paper concludes that the Department of History at the Obafemi Awolowo University is a force to reckon with in the comity of schools of history in sub-Saharan Africa.
The importance of viruses in ventilator-associated pneumonia
Authors: Shorr Andrew F. , Ilges Daniel T. , Micek Scott T. , Kollef Marin H. 
Published: September 2022

AbstractObjective:Ventilator-associated pneumonia (VAP) remains a challenge. The importance of viruses in VAP is not established. We sought to determine the prevalence of viruses in VAP and the outcomes of viral VAP.Design:Retrospective study of VAP over 3 years. The frequency of a viral process represented the primary endpoint. Clinical outcomes served as secondary endpoints. We identified variables independently associated with a virus and conducted sensitivity analyses to assess the interaction between type of infection and patient characteristics.Setting:Tertiary-care referral center.Patients:The final cohort consisted of 710 patients and a virus was isolated in 5.1%.Interventions:None.Results:The most common viruses included: rhinovirus, influenza A, and cytomegalovirus. Baseline characteristics were similar between those with and without viral infections. In logistic regression, immunosuppression (adjusted odds ratio [aOR], 2.97; 95% confidence interval [CI], 1.44–6.14) and stem-cell transplantation (SCT, aOR, 3.58; 95% CI, 1.17–10.99) were independently associated with a virus. The presence of either variable performed poorly as a screening test for a virus. In-hospital (22.4% vs 21.6%; P = .869) and 30-day (32.8% vs 27.9%; P = .448) mortality rates were similar between the cohorts, respectively. Sensitivity analyses restricted to patients without a mixed viral and bacterial infection or those who were immunocompetent yielded similar results.Conclusion:Although infrequent, a range of viruses may cause VAP. Viruses more often complicate SCT and immunosuppression, but one can isolate viruses in immunocompetent subjects. Viral VAP produces severe infection and results in high mortality rates. Clinical features do not differentiate viral from nonviral VAP.
Product differentiation and the relative importance of wine attributes: U.S. retail prices
Authors: Chandra Raj , Moschini GianCarlo 
Published: September 2022

AbstractThis paper investigates the relative importance of various attributes, including varietal, brands, and geographic origin, in explaining retail wine prices for the United States market. We use a metric based on the Shapely value, from cooperative game theory, in the context of an empirical hedonic price equation estimated using a large sample of retail wine sales for home consumption over the period 2007–2019. We find that brands alone explain more than 70% of the variation in wine prices, but geographic origin and varietals retain additional explanatory power. Furthermore, information about the geographic origin appears to be a considerably more important attribute than varietals.
Mycoprotein ingestion within or without its wholefood matrix results in equivalent stimulation of myofibrillar protein synthesis rates in resting and exercised muscle of young men
Authors: West Sam , Monteyne Alistair J. , Whelehan Gráinne , Abdelrahman Doaa R. , Murton Andrew J. , Finnigan Tim J. A. , Blackwell Jamie R. , Stephens Francis B. , Wall Benjamin T. 
Published: September 2022

AbstractIngestion of mycoprotein stimulates skeletal muscle protein synthesis (MPS) rates to a greater extent than concentrated milk protein when matched for leucine content, potentially attributable to the wholefood nature of mycoprotein. We hypothesised that bolus ingestion of mycoprotein as part of its wholefood matrix would stimulate MPS rates to a greater extent compared with a leucine-matched bolus of protein concentrated from mycoprotein. Twenty-four healthy young (age, 21 ± 2 years; BMI, 24 ± 3 kg.m2) males received primed, continuous infusions of L-[ring-2H5]phenylalanine and completed a bout of unilateral resistance leg exercise before ingesting either 70 g mycoprotein (MYC; 31·4 g protein, 2·5 g leucine; n 12) or 38·2 g of a protein concentrate obtained from mycoprotein (PCM; 28·0 g protein, 2·5 g leucine; n 12). Blood and muscle samples (vastus lateralis) were taken pre- and (4 h) post-exercise/protein ingestion to assess postabsorptive and postprandial myofibrillar protein fractional synthetic rates (FSR) in resting and exercised muscle. Protein ingestion increased plasma essential amino acid and leucine concentrations (P < 0·0001), but more rapidly (both 60 v. 90 min; P < 0·0001) and to greater magnitudes (1367 v. 1346 μmol·l–1 and 298 v. 283 μmol·l–1, respectively; P < 0·0001) in PCM compared with MYC. Protein ingestion increased myofibrillar FSR (P < 0·0001) in both rested (MYC, Δ0·031 ± 0·007 %·h–1 and PCM, Δ0·020 ± 0·008 %·h–1) and exercised (MYC, Δ0·057 ± 0·011 %·h–1 and PCM, Δ0·058 ± 0·012 %·h–1) muscle, with no differences between conditions (P > 0·05). Mycoprotein ingestion results in equivalent postprandial stimulation of resting and post-exercise myofibrillar protein synthesis rates irrespective of whether it is consumed within or without its wholefood matrix.
Reconstructing sedimentary processes in a Permian channel–lobe transition zone: an outcrop study in the Karoo Basin, South Africa
Authors: Pohl F , Eggenhuisen JT , de Leeuw J , Cartigny MJB , Brooks HL , Spychala YT 
Published: September 2022

AbstractTurbidity currents commonly bypass sediment in submarine channels on the continental slope, and deposit sediment lobes farther down-dip on the flat and unconfined abyssal plain. Seafloor and outcrop data have shown that the transition from bypass to deposition usually occurs over complex zones referred to as channel–lobe transition zones (CLTZs). Recognition of these zones in cores and outcrop remains challenging due to a lack of characteristic sedimentary facies and structures. This paper focuses on Unit E of the Permian Fort Brown Formation in the Karoo Basin, South Africa, in the Slagtersfontein outcrop complex, which has previously been interpreted as a CLTZ. This study integrates thin-section micrographs, sedimentary facies, bed-set and stratigraphic architecture, and palaeoflow directions to achieve a multiscale analysis of CLTZ features. A novel process-based facies scheme is developed to evaluate deposits in terms of the depositional or erosional tendencies of the flows that formed them. This scheme allows bypass to be distinguished from depositional zones by the spatial distribution of certain sediment facies. Areas of net sediment bypass were predominantly marked by erosive sediment facies and a larger variability in palaeoflow direction while depositional areas showed a lower variability in palaeoflow directions. Metre-scale structures in the bypass-dominated area reveal seafloor erosion and scour formation. Field relations suggest the presence of a ∼500 m long mega-scour in the CLTZ. The characteristic structures documented here are applicable for identifying CLTZs in sparse datasets such as outcrops with limited palaeogeographical context and sediment cores obtained from subsurface systems.
From Forced to Voluntary Labour in Rural Africa: The Transition to Paid Voluntary Labour on the Roads of the Northern Territories of the Gold Coast
Authors: Pont Cháfer María José 
Published: September 2022

AbstractForced labour was central to the provision of public infrastructure in African colonies. Whereas current historiography focuses on the role of external drivers, such as humanitarian organizations or the Forced Labour Convention of 1930, in triggering change, no attention has been paid to the local initiatives that contributed to the end of forced labour. This article explores the transition to paid voluntary labour in the context of road building and maintenance in the Northern Territories of the Gold Coast, a region where incentives to resort to compulsion were very high due to the lack of alternative sources of revenue to finance public works. The article shows that movements away from forced labour were shaped by local conditions, and rural populations played a crucial part in the shifts in labour relations.
Sentencing Reform in Tanzania: Moving from Uhuru to Ubuntu?
Authors: Roberts Julian V , Hoseah Edward 
Published: September 2022

AbstractThe scholarly literature on sentencing reform has largely overlooked the African continent. The paucity of legal scholarship is particularly striking with respect to Tanzania, one of Africa's largest and most populous countries. This article explores the first significant sentencing reform in Tanzania's history. In 2020, the Tanzanian judiciary issued a comprehensive set of sentencing guidelines for courts to follow. Until this point, sentencing was a highly discretionary stage of the criminal process, and the Tanzanian penal code offered very little guidance with respect to the exercise of that discretion. After providing a brief summary of the new sentencing regime, we explore the innovative guidance contained in the reforms. In the conclusion we discuss the extent to which the Tanzanian reforms reflect core African values of Ubuntu, or more specifically in the case of Tanzania, Ujamaa, the philosophy popularized by Tanzania's first president, Julius Nyerere.