bluuebunny/crossref_metadata_2025_split huggingface dataset:
Syncytin-mediated open-ended membrane tubular connections facilitate the intercellular transfer of cargos including Cas9 protein
Authors: Zhang Congyan , Schekman Randy 
Published: November 2022

AbstractMuch attention has been focused on the possibility that cytoplasmic proteins and RNA may be conveyed between cells in extracellular vesicles (EVs) and tunneling nanotube (TNT) structures. Here, we set up two quantitative delivery reporters to study cargo transfer between cells. We found that EVs are internalized by reporter cells but do not efficiently deliver functional Cas9 protein to the nucleus. In contrast, donor and acceptor cells co-cultured to permit cell contact resulted in a highly effective transfer. Among our tested donor and acceptor cell pairs, HEK293T and MDA-MB-231 recorded optimal intercellular transfer. Depolymerization of F-actin greatly decreased Cas9 transfer whereas inhibitors of endocytosis or knock-down of genes implicated in this process had little effect on transfer. Imaging results suggest that intercellular transfer of cargos occurred through open-ended membrane tubular connections. In contrast, cultures consisting only of HEK293T cells form close-ended tubular connections ineffective in cargo transfer. Depletion of human endogenous fusogens, syncytins, especially syncytin-2 in MDA-MB-231 cells, significantly reduced Cas9 transfer. Full-length mouse syncytin, but not truncated mutants, rescued the effect of depletion of human syncytins on Cas9 transfer. Mouse syncytin overexpression in HEK293T cells partially facilitated Cas9 transfer among HEK293T cells. These findings suggest that syncytin may serve as the fusogen responsible for the formation of an open-ended connection between cells.
Determinants of idiosyncratic risk: evidence from BRICS countries
Authors: Kausar Saba , Shah Syed Zulfiqar Ali , Rashid Abdul 
Published: November 2022

PurposeThis study examines the determinants of idiosyncratic risk (IR) or unsystematic risk. The study also examines the determinants of IR by dividing the firms into different categories: beta-based firms, liquid and illiquid firms and financially constrained (FC) and unconstrained (FUC) firms.Design/methodology/approachThe fixed effects static panel data model specifications are formulated based on Hausman (1978) test for BRICS (Brazil, Russia, India, China, and South Africa) member countries over the period 2000–2019. Moreover, the t-test is applied to see whether the returns of different types of portfolios are significantly different.FindingsThe portfolio analysis results show that, on average, high IR firms tend to be small in size, highly leveraged, have low competitiveness, low profitability, less dividend yield and low returns for all the sampled countries. The sample paired t-test also confirms that a significant difference exists between extreme portfolios: small and large size and low IR and high IR portfolios. The panel regression results show that firm size, market power, price-to-earnings ratio, return on equity (ROE) and dividend yield negatively relates to IR. Yet, both leverage and liquidity are positively related to IR. However, the sign of momentum returns is mostly positive for the entire sample. The coefficient values for high-beta, FC and illiquid firms are more significant and large than the firms' counterparts for all BRICS member countries. These results support the hypothesis of an under-diversified portfolio and suggest that the above-mentioned firm-specific variables are the significant determinants of unsystematic risk.Practical implicationsThe securities exchange commission, as the supervisor of the public limited companies, needs to increase its role in investor protection related to the uncertainty of investment in the capital market. Accordingly, in making investment decisions in a stock exchange, investors can use the information that captures unsystematic risk for investment decision-making.Originality/valueThis study is the first to explore the determinants of IR in top emerging countries. Second, none of the existing studies has focused on the determinants of the IR based on different categories of firms.
Labor market transformation in the hospitality gig economy in a post pandemic era: impacts of institutional governance
Authors: Lin Pearl M.C. , Peng Kang-Lin , Wilson Au Wai Ching , Baum Tom 
Published: November 2022

Purpose
The COVID-19 pandemic has caused the food delivery sector to boom as people continue to rely on services provided by online catering platforms (OCPs). However, because of the nature of sharing economy employment, gig workers’ contributions went largely ignored until intervention from institutional governance. This study aims to explore the impacts of labor market transformation after the Chinese Government issued guidance to promote gig workers’ welfare as a focal case.

Design/methodology/approach
Focus groups and the Delphi technique were used to explore associated impacts on OCPs and gig workers based on governance theory.

Findings
Results show that institutional governance negatively affected OCPs’ operating cost structure but sustained gig workers’ welfare. The dual effects of market mechanism and institutional governance in the sharing economy are needed to be balanced for labor market transformation.

Research limitations/implications
Long-term equilibrium can be fulfilled, given the growing food-related demand for the market mechanism. Social reciprocity is expected to be realized through institutional governance for gig workers’ welfare.

Originality/value
This study suggests that moving from market governance to stakeholder governance, as mediated by state governance, could transform gig workers’ labor structure in the gig economy. This study presents an integrated governance theory to enhance the epistemology of institutional governance.
Cognitive factors in discouraged borrowers: how entrepreneur's perception affects borrowing discouragement
Authors: Barasal Morales Adriano 
Published: November 2022

PurposeThis paper aims to investigate how cognitive factors affect borrowing discouragement among entrepreneurs. Specifically, the study tests the effects of overconfidence, dispositional optimism and entrepreneurial self-efficacy (ESE) on borrowing discouragement.Design/methodology/approachThe study relies on Fraser's (2014) theoretical model to formulate the hypotheses. The results are based on a small sample of French entrepreneurs drawn from the AMADEUS database. Hierarchical Probit estimations are used to access the effects of the cognitive factors on borrowing discouragement.FindingsThe findings suggest that optimistic entrepreneurs are less likely to feel discouraged, while miscalibrated entrepreneurs are more prone to feel borrowing discouragement. There was no significant result for ESE and discouragement.Originality/valueThe study brings new implications and insights to the literature that investigates factors that cause discouragement in entrepreneurs, as well as implications for policymakers.
Clustering of percentage gross spreads and the avoidance of underwriter switching
Authors: Lee Chin-Chong , Too Shaw Warn , Ooi Kuan San 
Published: November 2022

PurposeBoth issuing firms and underwriters shall benefit from the associations in underwriting contracts for seasoned equity offerings (SEOs). Issuing firms that are offered underwriting contracts with clustered gross spreads do not have strong incentives to switch away from the firms' prior SEO underwriters, and thus these existing underwriters are able to maintain or gain greater market share. This study investigates how the clustering of percentage gross spreads affects the likelihood of underwriter switching.Design/methodology/approachUsing the investment bank-underwritten SEOs in Hong Kong, the authors find that the percentage gross spreads of 40% of these SEOs are clustered at 2.5%. The seemingly unrelated bivariate probit model, Weibull survival mixed model and trivariate probit model are applied to analyse this phenomenon.FindingsThe authors' study provides first direct evidence that the clustering of percentage gross spreads lowers the likelihood of underwriter switching. Investment banks as underwriters can explicitly price underwriting contracts at a clustered level, more likely in periods of greater market volatility, and intentionally retain the banks' client firms using pricing arrangements. The authors' finding and approach offer more direct and distinct support that the issuer–underwriter association can be relationship-based.Originality/valueWhilst the clustering of fees is interpreted as a type of anticompetitive price sitting, the authors contribute to literature by providing new empirical evidence on why percentage gross spreads as a price dimension are clustered. On top of contract efficiency and collusion, this study's new evidence provides a third view for the clustering of gross spreads.
Corporate social responsibility disclosure and banks' performance: the role of economic performance and institutional quality
Authors: AlAjmi Jasim , Buallay Amina , Saudagaran Shahrokh 
Published: November 2022

PurposeThis study aims to examine the moderating role of a country's economic activities and institutional quality (IQ) on the relationship between corporate social responsibility disclosure (CSRD) and banks' operational, financial and market performance.Design/methodology/approachThis study examines 245 banks from emerging markets for 13 years (2008–2020), yielding unbalanced panel of 1899 bank-year observations. The independent variable is CSRD. The dependent variables are return on asset (ROA), return on equity (ROE) and Tobin Q. The authors used ordinary least square (OLS), panel fixed-effect and instrumental variables-generalized method of moments (IV-GMM) to estimate the parameters of the models.FindingsThe authors find that the CSRD scores negatively influence banks’ performance. The moderator of CSRD and the level of economic activities have a positive relationship with banks' performance. However, the moderator (CSRD and IQ), while showing positive relationship with banks' performance, has a significant effect only on banks' operational and financial performance.Originality/valueThis study provides new evidence on the ways in which economic performance and IQ (IQ) influence the CSRD practices of banks in emerging markets.Peer reviewThe peer review history for this article is available at https://publons.com/publon/10.1108/IJSE-11-2020-0757.
Immersive robotic telepresence system to support a person with intellectual and motor disabilities perform a daily task: a case study
Authors: Desideri Lorenzo , Cesario Lisa , Sidoti Chiara , Malavasi Massimiliano 
Published: November 2022

PurposeIn this proof-of-concept study, the authors assessed the feasibility of using a humanoid robot controlled remotely via an immersive telepresence system to support a person with intellectual and motor disabilities performing a daily task (i.e. setting a table for lunch).Design/methodology/approachThe system involved a head-mounted display and two joysticks. A teleoperator was able to see through the video cameras of the robot and deliver the instructions verbally to the participant located in a different room. To assess the system, a baseline phase (A) was followed by an intervention (i.e. tele-operated support) phase (B) and a return to a baseline phase (A).FindingsData showed a marked increase in the average frequency of task steps correctly performed from baseline (M = 15%) to intervention (M = 93%). Accuracy reached 100% in the return to baseline.Originality/valueThese preliminary findings, along with qualitative feedback from users, suggest that an immersive telepresence system may be used to provide remote support to people with intellectual and motor disabilities.
Ambidextrous leadership and sustainability performance: serial mediation effects of employees' green creativity and green product innovation
Authors: Lyu Chaolin , Peng Can , Li Ruixue , Yang Xiaona , Cao Dongqin 
Published: November 2022

PurposeThe purpose of this study is to explore the relationship between ambidextrous leadership and sustainability performance. In addition, this study also discusses how ambidextrous leadership affects sustainability performance through employees' green creativity and green product innovation.Design/methodology/approachThis study obtained research data from a questionnaire survey of 307 manufacturing enterprise leaders in China and used regression and bootstrap analysis to test the research hypotheses.Findings(1) Ambidextrous leadership positively influences sustainability performance. (2) Employees' green creativity mediates the relationship between ambidextrous leadership and sustainability performance. (3) Green product innovation also mediates the relationship between ambidextrous leadership and sustainability performance. (4) The intermediary chain constructed by employees' green creativity and green product innovation has serial mediation effects on the relationship between ambidextrous leadership and sustainability performance.Originality/valueThis study contributes to the literature on leadership and corporate sustainability by clarifying the relationship between ambidextrous leadership and sustainability performance. Meanwhile, this study reveals the influence mechanism of ambidextrous leadership on sustainability performance by analyzing the serial mediation effects of employees' green creativity and green product innovation.
Environmental disclosure and its relation to waste performance
Authors: Benjamin Samuel Jebaraj , Biswas Pallab Kumar , Wellalage Nirosha Hewa , Man Yimei 
Published: November 2022

Purpose
This paper aims to examine the association between environmental disclosure and waste performance.

Design/methodology/approach
This study is based on a sample of S&P 500 firms over a nine-year period from 2010 to 2018. The pooled ordinary least squares (OLS), logistic, propensity score matching (PSM) and instrumental variable-generalized method of moments regressions analyses have been used to examine the data.

Findings
The findings show a significant positive relationship between waste performance and environmental disclosure, suggesting that firms with superior waste performance tend to disclose more environmental information. Further, the authors distinguish between “hard” and “soft” environmental disclosures and find that the effect of waste performance is consistently positive and significant for each type. The observed positive and significant association of waste performance with environmental disclosure remains unchanged, regardless of the industry affiliation of firms, although firms from industries that are less environmentally sensitive provide a slightly higher level of environmental disclosure. The authors also explore possible channels that may explain the association between waste performance and environmental disclosure and find that litigation risk and cash holdings positively moderate the association. The finding remains robust to a number of alternative estimation approaches.

Originality/value
Overall, the authors present important evidence that waste performance is an important indicator of environmental disclosure. The findings are useful for corporations and stakeholders and have important implications around the globe as the authors continue to grapple with the ongoing issue of waste.
Russia’s invasion of Ukraine increased the synchronisation of global commodity prices
Authors: Ihle Rico , Bar‐Nahum Ziv , Nivievskyi Oleg , Rubin Ofir D. 
Published: November 2022

AbstractThe Russian Federation’s efforts to expand its regional political influence culminated in launching a full‐scale war of aggression on Ukraine on 24 February 2022. As both countries are large exporters of commodities crucial for global food and energy security, the resulting abrupt supply chains disruptions created substantial uncertainty in commodity markets worldwide. This study quantifies to what extent this major shock induced global commodity prices to move more synchronously by gauging their time‐varying comovement. Using the concordance index, it analyses the development of 15 key global commodity price indices from January 2010 to July 2022. We find that the supply chains disruptions increased synchronisation of grain, energy and fertiliser prices at the global level in direction and magnitude. Moreover, they resulted in contagion across numerous food and non‐food markets, creating a global covariate shock to food and energy security. Notably, the increased synchronisation at broad scale restricts the ability of consumers to mitigate the adverse effects of food and energy price inflation by resorting to inexpensive alternatives. Hence, policymakers must improve the resilience of global food supply chains sustainably such that adverse effects of attaining the Sustainable Development Goals in crises can be minimised.
Distribution ratios of ethanol and water between whole blood, plasma, serum, and erythrocytes: Recommendations for interpreting clinical laboratory results in a legal context
Authors: Jones Alan Wayne , Tilson Christopher 
Published: November 2022

AbstractThis article reviews the scientific literature dealing with the distribution of ethanol and water between whole blood (WB), plasma, serum, and erythrocytes (red‐blood cells). Knowledge of the ethanol distribution ratio is important when analytical results derived from hospital clinical laboratories are interpreted in a forensic context, such as during the prosecution of traffic offenders. Statutory blood‐alcohol concentration (BAC) limits for driving are defined as the concentration of ethanol in WB and not in plasma, serum or red‐blood cells. These bio‐fluids differ in their water content and thereby the concentrations of ethanol. Plasma and serum contain ~90%–92% w/w water, WB ~78%–80% w/w and erythrocytes ~64%–66% w/w. The mean plasma/WB and serum/WB distribution ratios of ethanol are therefore expected to be ~1.15:1 (91/79 = 1.15), which is in good agreement with values determined empirically. However, in individual cases, the actual distribution ratio will depend on the person's age, gender, and biochemical and hematological properties of the blood specimen, such as its hematocrit. For legal purposes, we recommend that the concentration of ethanol in plasma or serum determined at hospital laboratories is divided by a factor of 1.2, which would provide a conservative estimate of the co‐existing BAC and the chance of overestimating the true value is only 1 in 2000 (0.05%).
Modifying factors of PD‐L1 expression on tumor cells in advanced non‐small‐cell lung cancer
Authors: Avilés‐Salas Alejandro , Flores‐Estrada Diana , Lara‐Mejía Luis , Catalán Rodrigo , Cruz‐Rico Graciela , Orozco‐Morales Mario , Heredia David , Bolaño‐Guerra Laura , Soberanis‐Piña Pamela Denisse , Varela‐Santoyo Edgar , Cardona Andrés F. , Arrieta Oscar 
Published: November 2022

AbstractBackgroundProgrammed death ligand‐1 (PD‐L1) expression predicts immunotherapy utility in nononcogenic addictive lung adenocarcinoma (ADC). However, its reproducibility and reliability may be compromised outside clinical trials. This study aimed to evaluate factors associated with PD‐L1 expression in lung ADC.MethodsThis observational study assessed 547 tumor samples with advanced lung ADC from January 2016 to December 2020 in a single cancer institution. Tumor samples were stained by at least one approved PD‐L1 clone, SP263 (Ventana) or 22C3 (Dako), and stratified in tumor proportion score (TPS) <1%, 1–49%, or ≥50%.ResultsOf all the tumor samples, positive PD‐L1 staining was higher in poorly differentiated tumors (67.3% vs. 32.7%, p < 0.001). Analytical factors associated with a PD‐L1 high expression (TPS ≥ 50%) were the SP263 clone (19.6% vs. 8.2%, p < 0.001), time of archival tumor tissue <12 months (15.3% vs. 3.8%, p = 0.024), whenever the analysis was performed in the most recent years (2019–2020) (19.0% vs. 8.3%, p < 0.001), and whenever the analysis was performed by pathologists in the academic setting (Instituto Nacional de Cancerologia, INCan) (19.9% vs. 11.9%, p = 0.001). In the molecular analysis, EGFR wild‐type tumors had an increased proportion of PD‐L1 positive and PD‐L1 high cases (60.2% vs. 47.9%, p = 0.006 and 17.4% vs.8.5%, p = 0.004). A moderate correlation (r = 0.69) in the PD‐L1 TPS% was observed between the two different settings (INCan vs. external laboratories).ConclusionClinicopathological factors were associated with an increased PD‐L1 positivity rate. These differences were significant in the PD‐L1 high group and associated with the academic setting, the SPS263 clone, time of archival tumor tissue <12 months, and a more recent period in the PD‐L1 analysis.
Recent developments in empirical dynamic modelling
Authors: Munch Stephan B. , Rogers Tanya L. , Sugihara George 
Published: November 2022

Abstract

Ecosystems are complex and sparsely observed making inference and prediction challenging.

Empirical dynamic modelling (EDM) circumvents the need for a parametric model and complete observations of all system variables. Classical univariate approaches, which require time‐series observations of only a single focal variable, can produce verifiable out‐of‐sample forecasts; however, they can sometimes require long time series that may be difficult to obtain. More importantly, classical approaches limit the depth of mechanistic understanding that can be gained and the generalizability of forecasts to non‐analogue futures.

We review the main ideas of EDM and more recent extensions that expand their capabilities for improving forecasts and understanding mechanism.

Algorithms are now available that allow for missing data, unequal sampling intervals and combining short time series, which increase the number of datasets that can be used. Recent extensions of EDM to multivariate time series substantially expand the range of applications and mechanistic questions that can be addressed, including detecting causal coupling, tracking changing interactions in real time, leveraging short time series from information shared in coupled variables, modelling dynamically changing stability, scenario exploration, and management applications involving optimal control.
Role of the ghrelin system in alcohol use disorder and alcohol‐associated liver disease: A narrative review
Authors: Kharbanda Kusum K. , Farokhnia Mehdi , Deschaine Sara L. , Bhargava Raghav , Rodriguez‐Flores Marcela , Casey Carol A. , Goldstone Anthony P. , Jerlhag Elisabet , Leggio Lorenzo , Rasineni Karuna 
Published: November 2022

AbstractUnhealthy alcohol consumption is a global health problem. Adverse individual, public health, and socioeconomic consequences are attributable to harmful alcohol use. Epidemiological studies have shown that alcohol use disorder (AUD) and alcohol‐associated liver disease (ALD) are the top two pathologies among alcohol‐related diseases. Consistent with the major role that the liver plays in alcohol metabolism, uncontrolled drinking may cause significant damage to the liver. This damage is initiated by excessive fat accumulation in the liver, which can further progress to advanced liver disease. The only effective therapeutic strategies currently available for ALD are alcohol abstinence or liver transplantation. Any molecule with dual‐pronged effects at the central and peripheral organs controlling addictive behaviors and associated metabolic pathways are a potentially important therapeutic target for treating AUD and ALD. Ghrelin, a hormone primarily derived from the stomach, has such properties, and regulates both behavioral and metabolic functions. In this review, we highlight recent advances in understanding the peripheral and central functions of the ghrelin system and its role in AUD and ALD pathogenesis. We first discuss the correlation between blood ghrelin concentrations and alcohol use or abstinence. Next, we discuss the role of ghrelin in alcohol‐seeking behaviors and finally its role in the development of fatty liver by metabolic regulations and organ crosstalk. We propose that a better understanding of the ghrelin system could open an innovative avenue for improved treatments for AUD and associated medical consequences, including ALD.