bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benzothiazole‐based fluorescent probe for N2H4
Authors: Wang Hanlin , Huang Jiexun , Huang Weidong , Yang Longyuan 
Published: October 2022

AbstractA fluorescence enhancement probe 2‐[2‐(1,3‐benzothiazol‐2‐yl)phenyl]‐1H‐isoin‐dole‐1,3(2H)‐dione (HL1) for N2H4 was synthesized and characterized by using 2‐(2‐aminophenyl)benzothiazole as a fluorophore, and its spectroscopic properties had been researched. The results exhibited that HL1 was highly selective and sensitive to N2H4, and it had the excellent anti‐interference ability and displayed a fast response. The fluorescent intensity of HL1 showed a good linear relationship with the concentration of N2H4 (1.5–12.5 μmolL−1), and its detection limit was 0.12 μmol/L. In addition, HL1 was also applied for determining N2H4 levels in real water samples and imaging N2H4 in living HeLa cells.
Characterization of meningiomas with synthetic imaging
Authors: Ludovichetti Riccardo , Delattre Bénédicte , Boto José , LaGrange Daniela , Meling Torstein , Vargas Maria Isabel 
Published: October 2022

AbstractIntroductionSynthetic magnetic resonance imaging (SyMRI) is a novel quantitative and qualitative technique that permits the reconstruction of multiple image contrasts and quantitative maps from a single scan, thereby providing quantitative information and reducing scan times. The purpose of this study is to characterize intracranial meningiomas using SyMRI.MethodsThe study included 35 patients with meningiomas (6 males, 29 females; mean age 61 ± 17 years; range 21–90 years). Using 3T MR scanners, SyMRI was performed in addition to conventional FSET2, FLAIR, DWI, T1, and T1 with gadolinium. SyMRI software was used to generate T1, T2, and PD quantitative maps. Osirix MD was used to measure quantitative values of T1, T2, and PD using a ROI.ResultsWe analyzed 42 meningiomas, 8 of which were associated with edema, and 5 contained calcifications.Mean relaxivity values of meningiomas on synthetic T1, T2, and PD maps at 3T MRI were 1382.6 ± 391.7 ms, 95.6 ± 36.5 ms, and 89.1 ± 9.7 pu, respectively. Signal intensities in terms of T1, T2, and PD did not differ significantly between meningiomas with and without edema (p = .994, p = .356, and p = .221, respectively), nor between meningiomas containing and not containing calcifications (p = .840, p = .710, and p = .455, respectively). Values of T1 and T2 measured in meningiomas and the normal‐appearing white matter approximated reference values found in the literature with other quantitative methods.ConclusionThe presented method offers a novel approach to characterize meningiomas through their relaxation parameters measured with a SyMRI sequence.
Screening of malnutrition using Patient‐Generated Subjective Global Assessment tool and hand muscle strength in subjects with pancreatitis
Authors: Thantry Akshatha Nagaraj , Urooj Asna , Halumathigatta Nagappa Dinesh 
Published: October 2022

AbstractBackgroundPancreatitis patients are at an increased risk of malnutrition due to impaired digestion, absorption, and metabolism. The degree of malnutrition is dependent on the duration, viz. acute or chronic. Studies on nutritional status in patients with pancreatitis are limited. Prevalence of nutritional status, physical functioning, and muscle strength among the subjects are scarce globally. The main aim of this study was to screen the status of malnutrition using appropriate screening tools and to assess hand muscle strength among subjects.MethodA cross‐sectional study was conducted on 64 subjects (18–80 years old, 59 males and 5 females) in Mysore city, Karnataka. The patients were screened for malnutrition using a standard tool Patient‐Generated Subjective Global Assessment (PG‐SGA) and handgrip strength on both dominant and nondominant hands.ResultsThe majority of patients (n = 44) were categorized as moderately malnourished/suspected malnutrition (Stage B) according to PG‐SGA. A significant difference (p < 0.005) in handgrip strength was seen in men aged 31–40 (t = −3.287) and 41–50 (t = −5.487) years compared to healthy adults.ConclusionThis study was able to identify patients at risk of malnutrition when the PG‐SGA tool was used along with handgrip strength and other anthropometric parameters.
Excitation‐Wavelength‐Dependent Functionalities of Temporally Controlled Sensing and Generation of Singlet Oxygen by a Photoexcited State Engineered Rhodamine 6G‐Anthracene Conjugate
Authors: Zhao Hanjun , Takano Yuta , Sasikumar Devika , Miyatake Yukiko , Biju Vasudevanpillai 
Published: October 2022

AbstractThe present study provides design guidance for unique multipotent molecules that sense and generate singlet oxygen (1O2). A rhodamine 6G‐aminomethylanthracene‐linked donor‐acceptor molecule (RA) is designed and synthesized for demonstrating wavelength‐dependent functionalities as follows; (i) RA acts as a conventional fluorogenic 1O2 sensor molecule like the commercially available reagent, singlet oxygen sensor green (SOSG), when it absorbs ultraviolet (UV)‐visible light and reacts with 1O2. (ii) RA acts as a temporally controlled 1O2 sensing reagent under the longer wavelength (∼700 nm) photosensitization. RA enters an intermediate state after capturing 1O2 and does not become strongly fluorescent until it is exposed to UV, blue, or green light. (iii) RA acts as an efficient photosensitizer to generate 1O2 under green light illumination. The spin‐orbit charge transfer mediated intersystem crossing (SOCT‐ISC) process achieves this function, and RA shows a potential cancer‐killing effect on pancreatic cancer cells. The wavelength‐switchable functionalities in RA offer to promise molecular tools to apply 1O2 in a spatiotemporal manner.
A 2.71‐pA/√Hz ultra‐low noise, 70‐dB dynamic range CMOS transimpedance amplifier with incorporated microstrip line techniques over extended bandwidth
Authors: Gorre Pradeep , Vignesh R. , Kumar Sandeep , Song Hanjung , Roy Gunjan Mittal 
Published: October 2022

AbstractRecent advancements in the area of telemedicine have focused on remote patient monitoring services as a new frontier in medical applications. The present work reports a 65‐nm complementary metal–oxide–semiconductor (CMOS)‐based transimpedance amplifier (TIA) in an optical radar system for non‐contact patient monitoring. A T‐shaped microstrip line (MSL) integrated with variable gain common source TIA using MSL peaking technique and off‐chip post‐amplification integration is a newly proposed architecture to achieve a ultra‐low noise, high dynamic range (DR) and high figure of merit over broadband than a traditional TIAs. First, the integrated T‐shaped MSL develops an additional resonant frequency that resonates with a photodiode capacitance improving the bandwidth performance at higher Q values. Second, the shunt MSL peaking technique that introduces an additional conjugate pole‐pair that cancels the effect of input capacitance helps to further improve the bandwidth of the TIA. Finally, an active feedback concept achieves a wide linear dynamic range enabling high TIA detectability. The proposed TIA realizes an impedance bandwidth of 770 MHz ranging from 7.12 to 7.89 GHz with a transimpedance gain of 105.1 dBΩ and ultra‐low input‐referred noise (IRN) density of 2.71 pA/√Hz. A high linear DR of 70 dB is achieved by employing a variable gain control scheme with a low group delay variation of 0.81 ns. The proposed work demonstrates a 1‐Gb/s data rate while a bit‐error rate less than 10−12 is achieved. The TIA consumes a power of 0.82 mW under the supply voltage of 1.2 V.
Ecohydrology of coastal aquifers in humid environments and implications of a drying climate
Authors: Dyring Madeleine , Hofmann Harald , Stanton David , Moss Patrick , Froend Ray 
Published: October 2022

AbstractCoastal groundwater‐dependent ecosystems (GDEs), such as wetlands, estuaries and mangrove forests, are globally important habitats that promote biodiversity, provide climate regulation and serve as refugia for plant and animal communities. However, global warming, coastal development and over‐abstraction threaten the availability and quality of groundwater in coastal aquifers and, by extension, the ecohydrological function of dependent ecosystems. Because ecohydrological knowledge of coastal groundwater is disparate across disciplines and habitat types, we begin by summarising the physiochemical, biological and hydrological processes supported by groundwater across coastal watersheds. Groundwater makes a significant but poorly recognised contribution to the function and resilience of coastal ecosystems and will play an essential role in climate change mitigation and adaptation. This review then explores how critical ecosystem processes supported by groundwater will be affected in areas of the humid subtropics that are expected to be impacted by climatic drying. Where rainfall is predicted to decrease, reduced groundwater recharge will interrupt the hydrology of coastal GDEs, while anthropogenic pressures, such as land‐use intensification and pollution, will diminish the quality of remaining groundwater. The challenges of managing groundwater for multiple purposes under climate change predictions are highlighted. To improve the management of coastal GDEs, research should be aimed at developing robust conceptual models of coastal groundwater systems that quantify biophysical linkages with ecological communities across relevant spatiotemporal scales.
Highly extendable passive current balancing interleaved high step‐up boost converter using voltage multipliers
Authors: Koyama Kakeru , Uno Masatoshi , Inohara Hiroki 
Published: October 2022

AbstractHigh step‐up boost converters with large input current capacity are necessary for low‐voltage renewable energy sources, such as photovoltaic panels and fuel cells. Interleaved converters are a suitable topology for low‐voltage, large input current applications. Conventional interleaved converters, however, face a variety of challenges, such as the necessity of additional current control loops for active current balancing, increased voltage stress of semiconductors, and poor extendibility. In this paper, highly extendable interleaved high step‐up boost converters with a passive current balancing and reduced semiconductor voltage stresses are proposed. Current capacities and step‐up conversion ratios of the proposed converters can be arbitrarily enhanced by extending the number of phases and voltage multiplier (VM) stages, respectively. The experimental results of 500‐W prototypes demonstrated passive current balancing, reduced semiconductor voltage stresses, and enhanced step‐up conversion ratios.
Clinical performance and quality measures for heart failure management in China: the China‐Heart Failure registry study
Authors: Zhang Yuhui , Gao Chuanyu , Greene Stephen J. , Greenberg Barry H. , Butler Javed , Yu Jing , Zheng Zhaofen , Ma Genshan , Wang Lian , Yang Ping , Ji Xiaoping , Xu Dingli , Wang Jiang , Zhang Yao , Liu Ying , Zhao Yan , Qi Hong , Zhai Mei , Feng Jiayu , Huang Yan , Zhou Qiong , Zhang Jian 
Published: October 2022

AbstractAimsHeart failure (HF) remains a major public health problem with increasing prevalence in China. This study evaluated the clinical performance and quality measures for HF management to identify gaps in the standardization of care for patients hospitalized for HF in China.Methods and resultsFollowing the results of China‐HF stage I (2012–2015), the second stage of the China‐HF was launched in 2017. Among 113 hospitals with ≥100 cases, the China‐HF Stage II assessed the quality of care measures for HF and compared results with previous data in China and the US‐based Get with The Guidelines‐Heart Failure (GWTG‐HF) registries. In total, 34 938 patients hospitalized with HF were enrolled from January 2017 to October 2020. Echocardiographic left ventricular function and natriuretic peptide test were performed in 93.7% and 93.0% of the cases, respectively. Adherence to standardized guidelines in China‐HF stage II was higher than that in the China‐HF stage I, but generally lower than GWTG‐HF registry with 78.2% of eligible patients was prescribed oral diuretics, 78.7% renin‐angiotensin‐system inhibitors, and 82.2% beta‐blockers. Implantable cardioverter‐defibrillators and cardiac resynchronization devices were implanted in 3.9% and 14.6%, respectively. In contrast, the proportion of eligible patients discharged with spironolactone (87.8%) was higher than GWTG‐HF. The median length of hospitalization was 9 (6, 12) days, and 938 (2.8%) patients died or withdrew from treatment during hospitalization.ConclusionsDespite significant improvements in the use of guideline‐recommended testing and therapy, there remain major gaps in quality of care for patients hospitalized for HF in China that are generally larger than gaps observed in the United States.
Zoonoses and Animal Culling: The Need for One Health Policy
Authors: Lederman Zohar 
Published: October 2022

AbstractOne Health (OH) as a biomedical and social movement calls to reorient public health approaches toward more holistic, nonanthropocentric approaches that do not exclude the interests of animals and ecosystems. OH thus urges reexamination, from both scientific and moral perspectives, of the practice of culling pet, farm, or wild animals in the face of a zoonosis. Pandemics such as Covid and monkeypox highlight the need for more rigorous analysis of the justifications traditionally provided to back these culling practices. Such analyses should then ground reasonable OH policies and legislation that consider the rights of humans, animals, and the environment. Bill S.861, “Advancing Emergency Preparedness through One Health Act of 2021,” which was introduced in the U.S. Congress, is a step in the right direction.
Not Just for Nurses
Authors: Wocial Lucia 
Published: October 2022

AbstractWhile not perfect, Clinical Ethics Handbook for Nurses: Emphasizing Context, Communication and Collaboration, edited by Pamela Grace and Aimee Milliken (Springer, 2022), provides an excellent clinical ethics overview for any nurse, nursing student or faculty member, or anyone in clinical practice. The editors have successfully assembled a book that will help point‐of‐care nurses develop their skills in ethical decision‐making and assist nurse educators and nurse leaders in mentoring nurses who may be challenged to exercise moral agency on behalf of good patient care. Throughout the chapters, cases and exercises are introduced, providing practical strategies to improve nurses' confidence in ethical decision‐making both as individuals and in collaboration with others. The book is well grounded in the uniqueness of nursing, making it a must read for anyone who teaches clinical ethics or practices clinical ethics with nurses.
Ventricular segmentation and modeling using topological watershed transformation and harmonic state model
Authors: Mahmoudi Ramzi 
Published: October 2022

AbstractThis paper proposes an adapted ventricular segmentation method based on topological watershed transform. Segmentation will allow spatio‐temporal modeling of trajectories of the different points belonging to the borders of the ventricle using a harmonic motion model that is able to describe such motion over the entire cardiac cycle. In addition, extraction of the adopted canonical state vector and the corresponding state equations guarantees an optimal efficacy and a gradual transition from order n to order n + 1. To validate the proposed approach, an intern‐image base was used. Our results show a promising ability to discern whether subjects are healthy or pathological with an 80% success rate.
PrEP awareness and protective barrier negotiation among transgender people attracted to men in Aotearoa New Zealand
Authors: Byrne Jack L. , Tan Kyle K. H. , Saxton Peter J. , Bentham Ryan M. , Veale Jaimie F. 
Published: October 2022

AbstractIntroductionInternationally, trans women are disproportionately impacted by HIV, encounter specific barriers navigating safer sex and face inequities accessing HIV prevention, including pre‐exposure prophylaxis (PrEP). Aotearoa/New Zealand (hereafter Aotearoa) was one of the first countries internationally to publicly fund PrEP in 2018, including for trans people. However, few data exist on PrEP awareness or sexual negotiation among trans populations to guide implementation. We present the first Aotearoa data on trans people's ability to negotiate barrier protection and awareness of PrEP efficacy and availability.MethodsWe used data from a large, diverse community‐based nationwide survey of trans (including non‐binary) people in Aotearoa: Counting Ourselves (N = 1178) conducted from 21 June to 30 September 2018. Generalized regression analyses were carried out among participants who have had sex (n = 704; Mage = 32.5) to identify associations between demographic factors (age, gender and sexual attraction, ethnicity, income, education qualification and current sex work involvement) and the Trans‐Specific Barrier Negotiation Self‐Efficacy (T‐Barrier) Scale and PrEP awareness.ResultsThe mean value of a 40‐point T‐Barrier Scale was 33.45 (SD: 6.89), suggesting a relatively high perceived ability among our participants to negotiate protective barrier usages in different situations. Asian participants scored 3.46 points lower compared to Pākehā (White) participants, and trans women attracted to men (cisgender and/or trans men) scored 2.40 points higher than trans women not attracted to men. Three‐fifths (59.7%) were aware that PrEP reduced HIV risks and did not prevent sexually transmitted infections (STI) transmission, and only two‐fifths (40.2%) knew PrEP was publicly funded for trans people. In multivariate models, we found participants who were older, trans women or those with lower education qualifications were less likely to have increased levels of PrEP awareness.ConclusionsParticipants attracted to men have a higher potential need for PrEP and were more likely to report PrEP awareness and that they could negotiate protective barrier usage. However, trans women and those with lower educational qualifications reported lower levels of PrEP awareness. More trans‐competent sexual health education, drawing on the newly released PrEP guidelines, is needed to promote the benefits of PrEP in the Aotearoa HIV epidemic context, particularly for trans women.
Quantitative Assessment of Resting‐State Functional Connectivity MRI to Differentiate Amnestic Mild Cognitive Impairment, Late‐Onset Alzheimer's Disease From Normal Subjects
Authors: Mohammadian Fatemeh , Zare Sadeghi Arash , Noroozian Maryam , Malekian Vahid , Abbasi Sisara Majid , Hashemi Hasan , Mobarak Salari Hanieh , Valizadeh Gelareh , Samadi Fardin , Sodaei Forough , Saligheh Rad Hamidreza 
Published: October 2022

BackgroundAlzheimer disease (AD) is a neurological disorder with brain network dysfunction. Investigation of the brain network functional connectivity (FC) alterations using resting‐state functional MRI (rs‐fMRI) can provide valuable information about the brain network pattern in early AD diagnosis.PurposeTo quantitatively assess FC patterns of resting‐state brain networks and graph theory metrics (GTMs) to identify potential features for differentiation of amnestic mild cognitive impairment (aMCI) and late‐onset AD from normal.Study TypeProspective.SubjectsA total of 14 normal, 16 aMCI, and 13 late‐onset AD.Field Strength/SequenceA 3.0 T; rs‐fMRI: single‐shot 2D‐EPI and T1‐weighted structure: MPRAGE.AssessmentBy applying bivariate correlation coefficient and Fisher transformation on the time series of predefined ROIs' pairs, correlation coefficient matrixes and ROI‐to‐ROI connectivity (RRC) were extracted. By thresholding the RRC matrix (with a threshold of 0.15), a graph adjacency matrix was created to compute GTMs.Statistical TestsRegion of interest (ROI)‐based analysis: parametric multivariable statistical analysis (PMSA) with a false discovery rate using (FDR)‐corrected P < 0.05 cluster‐level threshold together with posthoc uncorrected P < 0.05 connection‐level threshold. Graph‐theory analysis (GTA): P‐FDR‐corrected < 0.05. One‐way ANOVA and Chi‐square tests were used to compare clinical characteristics.ResultsPMSA differentiated AD from normal, with a significant decrease in FC of default mode, salience, dorsal attention, frontoparietal, language, visual, and cerebellar networks. Furthermore, significant increase in overall FC of visual and language networks was observed in aMCI compared to normal. GTA revealed a significant decrease in global‐efficiency (28.05 < 45), local‐efficiency (22.98 < 24.05), and betweenness‐centrality (14.60 < 17.39) for AD against normal. Moreover, a significant increase in local‐efficiency (33.46 > 24.05) and clustering‐coefficient (25 > 20.18) were found in aMCI compared to normal.Data ConclusionThis study demonstrated resting‐state FC potential as an indicator to differentiate AD, aMCI, and normal. GTA revealed brain integration and breakdown by providing concise and comprehensible statistics.Evidence Level1Technical EfficacyStage 2
Persistence of neutrophil extracellular traps and anticardiolipin auto‐antibodies in post‐acute phase COVID‐19 patients
Authors: Pisareva Ekaterina , Badiou Stephanie , Mihalovičová Lucia , Mirandola Alexia , Pastor Brice , Kudriavtsev Andrei , Berger Marie , Roubille Camille , Fesler Pierre , Klouche Kada , Cristol Jean‐Paul , Thierry Alain R. 
Published: October 2022

AbstractIn the early phase of the pandemic, we were among the first to postulate that neutrophil extracellular traps (NETs) play a key role in COVID‐19 pathogenesis. This exploratory prospective study based on 279 individuals showed that plasma levels of neutrophil elastase, myeloperoxidase and circulating DNA of nuclear and mitochondrial origins in nonsevere (NS), severe (S) and postacute phase (PAP) COVID‐19 patients were statistically different as compared to the levels in healthy individuals, and revealed the high diagnostic power of these NETs markers in respect to the disease severity. The diagnostic power of NE, MPO, and cir‐nDNA as determined by the Area Under Receiver Operating Curves (AUROC) was 0.95, 097, and 0.64; 0.99, 1.0, and 0.82; and 0.94, 1.0, and 0.93, in NS, S, and PAP patient subgroups, respectively. In addition, a significant fraction of NS, S as well as of PAP patients exhibited aCL IgM/IgG and anti‐B2GP IgM/IgG positivity. We first demonstrate persistence of these NETs markers in PAP patients and consequently of sustained innate immune response imbalance, and a prolonged low‐level pro‐thrombotic potential activity highlighting the need to monitor these markers in all COVID‐19 PAP individuals, to investigate postacute COVID‐19 pathogenesis following intensive care, and to better identify which medical resources will ensure complete patient recovery.