bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum inflammatory cytokines as disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy
Authors: Riddell Dominique O. , Hildyard John C. W. , Harron Rachel C. M. , Hornby Natasha L. , Wells Dominic J. , Piercy Richard J. 
Published: November 2022

ABSTRACT
Duchenne muscular dystrophy (DMD) is a fatal muscle-wasting disease, caused by mutations in the dystrophin gene, characterised by cycles of muscle degeneration, inflammation and regeneration. Recently, there has been renewed interest specifically in drugs that ameliorate muscle inflammation in DMD patients. The DE50-MD dog is a model of DMD that closely mimics the human DMD phenotype. We quantified inflammatory proteins in serum from wild-type (WT) and DE50-MD dogs aged 3-18 months to identify biomarkers for future pre-clinical trials. Significantly higher concentrations of C-C motif chemokine ligand 2 (CCL2), granulocyte-macrophage colony-stimulating factor (GM-CSF or CSF2), keratinocyte chemotactic-like (KC-like, homologous to mouse CXCL1), TNFα (or TNF), and interleukins IL2, IL6, IL7, IL8 (CXCL8), IL10, IL15 and IL18 were detected in DE50-MD serum compared to WT serum. Of these, CCL2 best differentiated the two genotypes. The relative level of CCL2 mRNA was greater in the vastus lateralis muscle of DE50-MD dogs than in that of WT dogs, and CCL2 was expressed both within and at the periphery of damaged myofibres. Serum CCL2 concentration was significantly associated with acid phosphatase staining in vastus lateralis biopsy samples in DE50-MD dogs. In conclusion, the serum cytokine profile suggests that inflammation is a feature of the DE50-MD phenotype. Quantification of serum CCL2 in particular is a useful non-invasive biomarker of the DE50-MD phenotype.
Risk Stratification of Sentinel Node Metastasis Disease Burden and Phenotype in Stage III Melanoma Patients
Authors: Hussain Zahra , Heaton Martin J. , Snelling Andrew P. , Nobes Jenny P. , Gray Gill , Garioch Jennifer J. , Moncrieff Marc D. 
Published: November 2022

Abstract
Background
Currently, all patients with American Joint Committee on Cancer (AJCC) pT2b-pT4b melanomas and a positive sentinel node biopsy are now considered for adjuvant systemic therapy without consideration of the burden of disease in the metastatic nodes.

Methods
This was a retrospective cohort analysis of 1377 pT1-pT4b melanoma patients treated at an academic cancer center. Standard variables regarding patient, primary tumor, and sentinel node characteristics, in addition to sentinel node metastasis maximum tumor deposit size (MTDS) in millimeters and extracapsular spread (ECS) status, were analyzed for predicting disease-specific survival (DSS).

Results
The incidence of SN+ was 17.3% (238/1377) and ECS was 10.5% (25/238). Increasing AJCC N stage was associated with worse DSS. There was no difference in DSS between the IIIB and IIIC groups. Subgroup analyses showed that the optimal MTDS cut-point was 0.7 mm for the pT1b-pT4a SN+ subgroups, but there was no cut-point for the pT4b SN+ subgroup. Patients with MTDS <0.7 mm and no ECS had similar survival outcomes as the N0 patients with the same T stage. Nodal risk categories were developed using the 0.7 mm MTDS cut-point and ECS status. The incidence of low-risk disease, according to the new nodal risk model, was 22.3% (53/238) in the stage III cohort, with 49% (26/53) in the pT2b-pT3a and pT3b-pT4a subgroups and none in the pT4b subgroup. Similar outcomes were observed for overall and distant metastasis-free survival.

Conclusion
We propose a more granular classification system, based on tumor burden and ECS status in the sentinel node, that identifies low-risk patients in the AJCC IIIB and IIIC subgroups who may otherwise be observed.
La comunicación digital de los museos: análisis comparativo
Authors: Dos Santos Abad Jenifer , Piñeiro Naval Valeriano , Somoza Sabatés Isabel 
Published: November 2022

Según los preceptos de la nueva museología, los museos pasaron a tener un papel social y pedagógico muy significativo a lo largo del siglo XX. En la actualidad, más allá del espacio físico, las instituciones museísticas tienen la posibilidad de democratizar aún más el acceso a sus contenidos culturales y difundir el conocimiento entre la población. Con la digitalización y el avance de las tecnologías, la comunicación ha experimentado cambios a varios niveles: por un lado, los medios han tendido hacia la convergencia y, por el otro, la manera en la que las instituciones y los usuarios interactúan también se ha visto afectada por la cultura participativa. Partiendo del escenario descrito, la propuesta de esta investigación consiste en analizar la comunicación museística a través de medios digitales. De manera más concreta, se aplicará el análisis de contenido a una muestra de 100 museos de Brasil, España, México y Portugal para observar cómo está siendo articulada su comunicación a través de los websites oficiales y en la red social Instagram. En última instancia, se comprobará si estas herramientas ejercen como promotoras potenciales del acceso a la cultura y al patrimonio.
Designing Approximately Optimal Search on Matching Platforms
Authors: Immorlica Nicole , Lucier Brendan , Manshadi Vahideh , Wei Alexander 
Published: November 2022

We study the design of a decentralized two-sided matching market in which agents’ search is guided by the platform. There are finitely many agent types, each with (potentially random) preferences drawn from known type-specific distributions. Equipped with knowledge of these distributions, the platform guides the search process by determining the meeting rate between each pair of types from the two sides. Focusing on symmetric pairwise preferences in a continuum model, we first characterize the unique stationary equilibrium that arises given a feasible set of meeting rates. We then introduce the platform’s optimal directed search problem, which involves optimizing meeting rates to maximize equilibrium social welfare. We first show that incentive issues arising from congestion and cannibalization make the design problem fairly intricate. Nonetheless, we develop an efficiently computable search design whose corresponding equilibrium achieves at least [Formula: see text] the social welfare of the optimal design. In fact, our construction always recovers at least [Formula: see text] the first-best social welfare, where agents’ incentives are disregarded. Our search design is simple and easy to implement, as its corresponding bipartite graph consists of disjoint stars. Furthermore, our design implies the platform can substantially limit choice and yet induce an equilibrium with approximately optimal welfare. We offer alternative search designs with improved approximation factors for markets with certain special structures. Finally, we show that approximation is likely the best one can hope for by establishing that the problem of designing optimal directed search is [Formula: see text]-hard to even approximate beyond a certain constant factor. This paper was accepted by Omar Besbes, revenue management and market analytics. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4601 .
A Label-State Formulation of Stochastic Graphon Games and Approximate Equilibria on Large Networks
Authors: Lacker Daniel , Soret Agathe 
Published: November 2022

This paper studies stochastic games on large graphs and their graphon limits. We propose a new formulation of graphon games based on a single typical player’s label-state distribution. In contrast, other recently proposed models of graphon games work directly with a continuum of players, which involves serious measure-theoretic technicalities. In fact, by viewing the label as a component of the state process, we show in our formulation that graphon games are a special case of mean field games, albeit with certain inevitable degeneracies and discontinuities that make most existing results on mean field games inapplicable. Nonetheless, we prove the existence of Markovian graphon equilibria under fairly general assumptions as well as uniqueness under a monotonicity condition. Most importantly, we show how our notion of graphon equilibrium can be used to construct approximate equilibria for large finite games set on any (weighted, directed) graph that converges in cut norm. The lack of players’ exchangeability necessitates a careful definition of approximate equilibrium, allowing heterogeneity among the players’ approximation errors, and we show how various regularity properties of the model inputs and underlying graphon lead naturally to different strengths of approximation. Funding: D. Lacker was partially supported by the Air Force Office of Scientific Research [Grant FA9550-19-1-0291] and the National Science Foundation [Award DMS-2045328].
A Low-Rank Approximation for MDPs via Moment Coupling
Authors: Zhang Amy B. Z. , Gurvich Itai 
Published: November 2022

Markov Decision Process Tayloring for Approximation Design Optimal control problems are difficult to solve for problems on large state spaces, calling for the development of approximate solution methods. In “A Low-rank Approximation for MDPs via Moment Coupling,” Zhang and Gurvich introduce a novel framework to approximate Markov decision processes (MDPs) that stands on two pillars: (i) state aggregation, as the algorithmic infrastructure, and (ii) central-limit-theorem-type approximations, as the mathematical underpinning. The theoretical guarantees are grounded in the approximation of the Bellman equation by a partial differential equation (PDE) where, in the spirit of the central limit theorem, the transition matrix of the controlled Markov chain is reduced to its local first and second moments. Instead of solving the PDE, the algorithm introduced in the paper constructs a “sister”' (controlled) Markov chain whose two local transition moments are approximately identical with those of the focal chain. Because of this moment matching, the original chain and its sister are coupled through the PDE, facilitating optimality guarantees. Embedded into standard soft aggregation, moment matching provides a disciplined mechanism to tune the aggregation and disaggregation probabilities.
Effective Information Infrastructures for Collaborative Organizing: The Case of Maasai Mara
Authors: Håkonsson Dorthe Døjbak , Larsen Erik Reimer , Eskildsen Jacob Kjær 
Published: November 2022

This study focuses on how collaborative organizing is achieved in a natural-resource commons, organized as an actor-oriented structure. In a framed field experiment, teams of Maasai livestock owners played a board game related to sustainable usage and preservation of a commons (in this case, grazing areas). We examine team decisions over time and draw inferences about the difference between two information infrastructures: one that enables learning about the ecosystem and one that enables shared situational awareness. We also examine the effectiveness of these information infrastructures in obtaining sustainable usage and preservation of a commons, finding that participants who are subjected to an information infrastructure that enables shared situational awareness are more effective than those subjected to an information infrastructure that only enables learning about the ecosystem. This, we argue, is because shared situational awareness enables members to address their interdependencies related to both task and knowledge interdependence. In other words, without shared situational awareness, they are less efficient at coordinating their actions, despite sharing collaborative values. Based on our findings, we argue that actor-oriented structures should be designed to include information infrastructures that specifically address members’ interdependencies.Funding: This work was financially supported by the Interacting Minds Centre (IMC).Supplemental Material: The e-companion is available at https://doi.org/10.1287/orsc.2022.1642 .
Utility Maximizing Load Balancing Policies
Authors: Goldsztajn Diego , Borst Sem C. , van Leeuwaarden Johan S.H. 
Published: November 2022

Consider a service system where incoming tasks are instantaneously dispatched to one out of many heterogeneous server pools. Associated with each server pool is a concave utility function that depends on the class of the server pool and its current occupancy. We derive an upper bound for the mean normalized aggregate utility in stationarity and introduce two load balancing policies that achieve this upper bound in a large-scale regime. Furthermore, the transient and stationary behavior of these asymptotically optimal load balancing policies is characterized on the scale of the number of server pools in the same large-scale regime. Funding: This work was supported by the Netherlands Organization for Scientific Research (NWO) through [Gravitation Grant NETWORKS-024.002.003] and [Gravitation Grant Vici 202.068]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/stsy.2022.0103 .
Description of the technique for laparoscopic radical prostatectomy in canine cadavers: 2D vs. 3D camera
Authors: Monnet Eric , Hafez Ahmed 
Published: November 2022

Objective
To describe the technique of laparoscopic radical prostatectomy in canine cadavers.

Study design
Cadaveric study.

Animals
8 canine cadavers.

Methods
Specimens were randomly divided into a 2D or 3D group. The vesicourethral anastomosis (VUA) was performed with 5 mm laparoscopic needle holders. A unidirectional barbed suture was used to complete the VUA with two simple continuous suture patterns. The number of stitches placed, the patency of the anastomosis, and the distance between the VUA and the ureters were recorded.

Results
Four dogs were entered into each group. The prostatectomy was completed in each dog following the same technique. VUA were completed with nine stitches (range: 8–10 stitches) for the 2D group and ten stitches (range: 9–11 stitches) for the 3D group (p<0.176). All the stitches were placed full thickness. The VUA was patent in each case. The left ureter was 1.05 cm (range: 0.5 to 1.1cm) from the VUA in the 2D group and 1.8 cm (range: 1.3–1.8 cm) for the 3D group (p< 0.025). The right ureter was 1.5 cm (range: 1 to 2 cm) from the VUA in the 2D group and 1.75 cm (range: 1.3–2 cm) for the 3D group (p< 0.55).

Conclusion
Laparoscopic radical prostatectomy can be performed with a 2D or a 3D camera in canine cadavers. The 3D camera results in more accurate placement of the sutures since they were placed further away from the left ureter.

Clinical significance
Radical prostatectomy with laparoscopy should be considered for dogs.
Spatial variation of overweight/obesity and associated factor among reproductive age group women in Ethiopia, evidence from EDHS 2016
Authors: Enyew Ermias Bekele , Birhanu Abraham Yeneneh , Mewosha Wondwossen Zemene 
Published: November 2022

BackgroundGlobally, at least 4.7 million people die from being overweight or obese. In Ethiopia, the level of overweight and obesity among women grew from 3% to 8%. However, as far as my literature searching, studies concerning the spatial variation of overweight/obesity and factors associated are not researched in Ethiopia using geospatial techniques. Therefore, this study aimed to explore the spatial variation of overweight/obesity and factor associated among reproductive age group women in Ethiopia using geospatial techniques.MothedA total weighted sample of 10,928 reproductive age women were included in the study. ArcGIS version10.7 was used to explore the spatial variation of overweight/obesity. Bernoulli based model was used to analyze the purely spatial cluster detection of overweight/obesity through SaTScan version 9.6.1 software. Ordinary Least Square analysis and geographically weighted regression analysis was employed to assess the association between an outcome variable and explanatory variables by using ArcGIS 10.7 software. P value of less than 0.05 was used to declare statically significant.ResultThe spatial distribution of overweight/obesity in Ethiopia was clustered. Statistically, a significant-high hot spot overweight/obesity was identified at Addis Ababa, harrari, Dire Dawa. SaTScan identified 66 primary spatial clusters (RR = 4.17, P < 0.001) located at Addis Ababa, southeast amhara, central part of oromia region and northern part of SNNP region. In geographically weighted regression, rich wealth index, women’s age (35–39 and 40–44 years), watching TV, internet use and not working were statistically significant that affecting spatial variation of overweight/obesity.ConclusionIn Ethiopia, overweight/obesity varies across the region. Statistically, significant-high hot spots of overweight/obesity were detected in Addis Ababa, Harari, Dire Dawa, some parts of Amhara and afar region, most of the Oromia and Somalia region, and the South Nation Nationality and People region of Ethiopia. Therefore, the ministry of health and the Ethiopian public health institute, try to initiate policies and practices that could include providing funding for physical education as well as recreational centers in communities most in need. In addition, public and private mass media create awareness of healthy lifestyles is promoted by health education regarding increased physical activity and reduced sedentary behavior through various media platforms.
Healthcare provider and patient/family perceptions of continuous pressure imaging technology for prevention of pressure injuries: A secondary analysis of patients enrolled in a randomized control trial
Authors: Ocampo Wrechelle , Sola Darlene Y. , Baylis Barry W. , Conly John M. , Hogan David B. , Kaufman Jaime , Kiplagat Linet , Stelfox Henry T. , Ghali William A. , Ho Chester 
Published: November 2022

Introduction
Despite the availability of various pressure injury (PI) prevention strategies (e.g., risk identification, use of pressure re-distribution surfaces, frequent repositioning), they persist as a significant issue for healthcare systems worldwide. Continuous pressure imaging (CPI) is a novel technology that could be integrated within a comprehensive approach to the prevention of PIs. We studied the perceptions of healthcare providers and patients/families to identify facilitators and barriers to the use of this technology.

Methods
Hospitalized patients/family members from a randomized controlled trial assessing the efficacy of CPI in preventing PIs completed a survey after 72 hours (or upon discharge from hospital) of CPI monitoring. They were asked questions about prior and current experience with CPI technology. For healthcare providers, perceptions on the use of the device and its impact on care were explored through a survey distributed by email or hard copies.

Results
A total of 125 healthcare providers and 525 patients/family members completed the surveys. Of the healthcare providers, 95% either agreed/strongly agreed that the CPI technology was easy to use and 65% stated that the device improved how they provided pressure relief for patients. Identified issues with the device were cost, the fitting of the mattress cover, and the fixation of the patients/families on the device. Over a quarter of the patient/family respondents agreed/strongly agreed that the device influenced how pressure relief was provided. This response was statistically associated with whether the monitor was turned on (intervention arm; 52.7%) or off (control arm; 4.2%).

Discussion and conclusion
CPI technology was positively perceived by healthcare providers. Most patients/families felt it influenced care when the CPI monitor was turned on. Concerns raised around cost and the ease of use of these devices by healthcare providers may affect the decisions of healthcare system administrators to adopt and implement this technology.
Translation and psychometric evaluation of Smartphone Addiction Scale—Short Version (SAS-SV) among Chinese college students
Authors: Zhao Hao , Rafik-Galea Shameem , Fitriana Mimi , Song Tian-Jiao 
Published: November 2022

Background
Smartphone addiction is very prevalent among college students, especially Chinese college students, and it can cause many psychological problems for college students. However, there is no valid research instrument to evaluate Chinese college students’ smartphone addiction.

Objective
This study aimed to translate the Smartphone Addiction Scale—Short Version (SAS-SV) into Chinese and evaluate the psychometric characteristics of the Smartphone Addiction Scale- Chinese Short version (SAS-CSV) among Chinese college students.

Methods
The SAS-SV was translated into Chinese using the forward-backward method. The SAS-CSV was completed by 557 Chinese college students (sample 1: n = 279; sample 2: n = 278). 62 college students were randomly selected from the 557 Chinese college students to be meas- ured twice, with an interval of two weeks. The reliability of the SAS-CSV was evaluated by internal consistency reliability and test-retest reliability, and the validity of the SAS-CSV was evaluated by content validity, structural validity, convergent validity, and discriminant validity.

Results
The SAS-CSV presented good content validity, high internal consistency (sample 1: α = 0.829; sample 2: α = 0.881), and good test-retest reliability (ICC: 0.975; 95% CI: 0.966–0.985). After one exploratory factor analysis, three components (tolerance, withdrawal, and negative effect) with eigenvalues greater than 1 were obtained, and the cumulative variance contribution was 50.995%. The results of confirmatory factor analysis indicated that all the fit indexes reached the standard of good model fit (χ2/df = 1.883, RMSEA = 0.056, NFI = 0.954, RFI = 0.935, IFI = 0.978, TLI = 0.969, CFI = 0.978). The SAS-CSV presented good convergent validity for the factor loading of all the items ranged from 0.626 to 0.892 (higher than 0.50), the three latent variables’ AVE ranged from 0.524 to 0.637 (higher than 0.50), and the three latent variables’ CR ranged from 0.813 to 0.838 (higher than 0.70). Moreover, the square roots of the AVE of component 1 (tolerance), component 2 (withdrawal) and component 3 (negative effect) were 0.724, 0.778, and 0.798, respectively, higher than they were with other correlation coefficients, indicating that the SAS-CSV had good discrimination validity.

Conclusion
The SAS-CSV is a valid instrument for measuring smartphone addiction among Chinese college students.
Application of Robotics in Manufacturing Industry
Authors: richard Rommel 
Published: November 2022

ABSTRACT
Usage for robotic systems can be found in many manufacturing companies, including stores and
factories. Robotic systems are crucial towards the smart factory in just this modern generation of
industry, which has resulted in a major increase in output. Organizations could lower
manufacturing costs, increase output efficiency, and improve product and service by using robotic
technology. This robot arm requires a substantial investment; however, it also offers substantial
rewards. Automated machines are thus worthwhile investments because they operate productively
in manufacture. Business robots are equipment that can be configured to carry out manufacturingrelated
operations for automobiles. Machines are used in many numerous sectors for terms of
installed capacity and high levels of output. These robots can perform intricate sequences of tasks.
Production robotics can carry out a variety of tasks, including assembly as well as elements that
enable. These are indeed created to carry out a variety of assembly tasks and decrease the time
required to produce them. Throughout fact, Artificial Intelligence and machine learning algorithms
were built into robotic arms that aid its manufacturers in reacting to critical situations. Robotic
systems usage in automotive plants have risen because of the quick development of automated
systems and robotics techniques. Many industrial machines were employed that carry out a variety
of repeatable activities, producing high-quality output. As a result, industrialized automation has
use in a variety of manufacturing-related tasks. It is made to be used in hazardous environments
such as those involved in explosive disarming, thorough monitoring of radioisotopes, etc.