bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical significance of epidermal growth factor receptor mutations in resected stage IA non-small cell lung cancer
Authors: Tsai Yuan-Ming , Lin Kuan-Hsun , Kuo Yen-Shou , Lin Yu-Chieh , Chien Yu-Hsin , Chou Hsiu-Ping , Chen Ying-Yi , Huang Hsu-Kai , Wu Ti-Hui , Chang Hung , Lee Shih-Chun , Huang Tsai-Wang 
Published: June 2022

Background:
Epidermal growth factor receptor (EGFR) gene mutation is a known predictor of the response to EGFR tyrosine kinase inhibitors. However, detecting EGFR mutations is a potential challenge because of the ground-glass opacity component, and its prognostic value for stage IA lung adenocarcinoma remains controversial. This study aimed to investigate the associations between EGFR mutation status, clinicopathological characteristics, and prognosis in surgically resected stage IA non-small cell lung cancer (NSCLC).

Materials and Methods:
We retrospectively examined the data of patients who underwent surgical resection for lung cancer between 2004 and 2014. The clinical data, imaging characteristics of nodules, surgical approaches, and outcomes were analyzed.

Results:
A total of 429 patients (female, n = 303; male, n = 126) with surgically resected stage IA NSCLC were analyzed and 343 were nonsmokers. The EGFR mutation rate was 48.3% (n = 207). Of the patients, 192 (44.8%) had stage IA1, 165 (38.5%) had stage IA2, and 72 (16.8%) had stage IA3 NSCLC. In the analysis of the correlations between clinicopathological features and EGFR status, older age (P = 0.032), nonsmoking history (P = 0.039), and pathological stage (P < 0.05) were related to EGFR mutation. Patients with stage IA2 NSCLC had a higher positive expression of EGFR than patients with stages IA1 and IA3. The 5-year overall survival rates and disease-free survival rates were better in the EGFR mutation group; however, the difference was not statistically significant.

Conclusion:
EGFR mutations are common in older and nonsmoking patients with stage IA NSCLC. Further separate analyses of EGFR gene mutations and pathological stage could improve the diagnostic performance and predict patients with unavailable EGFR gene testing who may benefit from targeted drug treatment.
CONTRIBUTION OF PAKISTANI FEMALE RESEARCHERS IN ICT: A BIBLIOMETRIC ANALYSIS
Authors: Kumari Sapna , Bhatti Sania , Memon Mohsin Ali , Kumari Arsha , Umar Aqsa 
Published: June 2022

This paper analyses the contribution of Pakistani female researchers in the field of ICT using the bibliometric analysis method. It helps to observe a female researcher’s productivity and assists in identifying problems, such as the need to empower female researchers in ICT. No such work has been conducted yet on gender-based bibliometric analysis in Pakistan. In this paper, bibliometric data of 300 female researchers were extracted from Google Scholar profiles. With the help of this study, the most prestigious female researcher in the field of ICT from Pakistan was analysed based on the h-index. Also, the most active ICT institute in terms of female research productivity (the number of publications) was observed. Furthermore, the annual growth rate of 15 years (2006–2021) of female-led research is calculated and is analysed that the maximum annual growth rate of research productivity (140.965) was in 2010. Additionally, the active contribution of female researchers in most trending research areas of ICT was found by generating the co-occurrence network diagram using 3,640 research paper titles. According to the co-occurrence network diagram, the most popular research areas are image classification and prediction, Internet of Things (IoT), wireless sensor network and smart grid, fuzzy logic and deep learning.
Kinetic, thermodynamic and isotherm studies on the removal of rhodamine b dye using acid activated Abutilon Indicum
Authors: Pandian P  , Kasthuri A  
Published: June 2022

The research of the present work was to investigate the removal of Rhodamine B dye from aqueous solution using Acid Activated Abutilon Indicum leaves (AAAI). Generally, dyes are organic compounds used as colouring products in chemical, textile, paper, printing, leather, plastics and various food industries. There is a need for the treatment of dye contaminated waste water passed out from the industry due to its harmful effects. In this study, the activated carbon prepared from Abutilon Indicum leaves was studied for its potential use as an adsorbent for the removal of a cationic dye, Rhodamine B. The various factors affecting the adsorption viz., initial dye concentration, contact time, adsorbent dose and temperature were evaluated. The experimental data were fitted into the pseudo-second order kinetic model. The equilibrium of adsorption was modeled using the Langmuir and Freundlich isotherms. The objective of the present work suggests that the AAAI can be utilized as a low cost adsorbent for the removal of Rhodamine B dye from aqueous solution.
Eco-friendly fireworks for atom bomb (Local name of cracker bomb)
Authors: Srinivasan K  
Published: June 2022

Most of fireworks composition contains sulphur as a fuel, during combustion reaction with oxidizer it gives sulphur dioxide (SO­2) gas. SO2 gas produces environmental pollution; due to that, less quantity of sulphur to be used in fireworks composition otherwise should be avoided fully. In the atom bomb or crackers formulation the roll of sulphur is most important due to it speed up the reaction and at the same time heat produced by this composition (KNO3,Ba(NO3)2, Al and Sulphur) is less when compared to without sulphur. Even though the sulphur containing formulations are desired by the most of fireworks formulators due to speed of reaction. Environmental concern in this proposed work the amount of sulphur to be reduced/without sulphur for atom bomb/cracker formulations.
Removal of Machine industrial from wastewater using cylindrical flow reactor by electrochemical oxidation and optimization of treatment conditions
Authors: Kalaivanan C  , Yosuva Suvaikin M  
Published: June 2022

This work examines the use of electrooxidation for treatment of wash water obtained from industry. Cutting oil was mainly found in the wastewater. The effluent was treated using NaCl as supporting electrolyte using a cylindrical flow reactor in continuous (single pass) mode under various current densities (2-5 A/dm2) and different flow rate (10-40 L/h). By cyclic voltammetric (CV) analysis, the best condition for maximum redox reaction was found. Efficiency of COD reduction and power consumption were studied for each operating conditions. From the results maximum COD reduction of about 93.3 % was obtained at a flow rate of 10 L/h with applied current density of 4 A/dm2. FT-IR spectra studies showed that during electrooxidation, the intensities of characteristic functional groups such as C-H, O-H were reduced and also some new peaks comes to appear. Probable theory, reaction mechanism and modeling were proposed for the oxidation of machine industrial effluent. All the experimental results have indicated that electrooxidation treatment was very effective and was capable of elevating quality of the treated wastewater effluent to the reuse standard of the machine industry.
Pengaruh Promosi dan E-Service Quality terhadap Minat Beli Ulang Penggunaan Gopay
Authors: Putri Tunggadewi Felien , Pudjoprastyono Hery 
Published: June 2022

This research aims to analyze: The effect of promotion and E-Service Quality on the interest in buying backs using Gopay. The population used in this study is consumers who have used GOPAY. The study used primary data using questionnaires distributed to 70 respondents from consumers who had used GOPAY. This study used questionnaire data collection methods with non-probability sampling / nonrandom sampling techniques. In this study, the data analysis used is a component-based Structural Equation Modeling (SEM) Method using the Least Square partial analysis tool (PLS). The results of this study show that promotion has an effect on the interest of GOPAY consumer repurchase. qulity e-service affects GOPAY consumer repurchase interest
Keywords: Promotion; E-Service; Re-buy Interest, Gopay
Analisis Peran Seksi Penyelenggara Syariah Dalam Pengumpulan Zakat Profesi ASN di Lingkungan Kantor Kementerian Agama Kota Medan
Authors: Putri Dinda Melani , Nawawi Zuhrina M. 
Published: June 2022

Every muslim wants to echieve perfection in worship by carrying out all the commands of Allah SWT and staying away from all his prohibilitions. The pilliars of Islam and the pilliars of faith are guidelines for muslims to become true Muslims. There are five pilliars, islam and paying zakat is an obligation that must be issued by someone who has excess assets. Profesional zakat is part of zakat maal which must be issued on essest derived from regular income work that does not violate islamic law. Baznas after entrusting to the agency or company to collect zakat for its employees. The perpose of this study is to find out how the role of the islamic organizer section in collecting professional zakat is in the office of the ministry of religion in the city of Medan. The main problem related to this research is the effort and role of the islamic organizer section in collecting professional zakat. The object of this research is the islamic organizer secton of the Medan city ministry of religion.
Keywords : Professional Zakat, Collection, Syariah administration section.
Analisis Penyusunan Anggaran Berbasis Kinerja dan Realisasi Anggaran pada Badan Pengelolaan Keuangan dan Asset Daerah Pemerintahan Kota Medan
Authors: Ritonga Jukhairia , Nurlaila Nurlaila 
Published: June 2022

The purpose of this study is the realization of the budget based on the performance and analysis of the budget report at the Regional Financial and Asset Management Agency of the Medan City Government during the 2020-2021 fiscal year. The application of the method in this research is descriptive qualitative, by collecting data through interviews and observations. Based on the research conducted, it was found that there was an influence of the budget with the realized budget, and this became quite appropriate for the Medan City Government BPKAD, so that it became a natural thing if there were funds that had not been delivered to be realized due to the pandemic period that was hitting Indonesia.
Keywords: Budgeting, Budget Realization
The relationship between the prognostic nutritional index and the clinical course of COVID-19: a single-center experience
Authors: ARSLAN Kadem , BAŞ Süleyman 
Published: June 2022

Aim: It was aimed to investigate the relationship between the prognostic nutritional index (PNI) and the clinical course in COVID-19 because the nutritional status is important in defense against infection.
Material and Method: 1579 patients who applied to the hospital inpatient clinic between 01/04/2020 and 30/11/2020 were included in the study. The PNI scores of the patients were calculated at the time of admission to the hospital. Comparisons were made between PNI scores of the patients and intensive care unit admission status, treatment results, length of hospital stay, and presence of pneumonia on thorax CT. Moreover, comparisons were made between PNI scores and C-reactive protein (CRP), neutrophil/ymphocyte ratio (NLR), CRP/albumin ratio.
Results: A total of 1579 patients (755 females and 824 males) were included in the study. The rate of admission to the ICU was significantly higher in males. The mortality rate of the study group was 9.4%. PNI scores were found to be significantly lower in patients who died and in patients admitted to the ICU. CRP and CRP/albumin ratio levels were significantly higher in patients with pneumonia on thorax CT, in patients admitted to the intensive care unit, and in patients who died. There were a significant negative correlation between PNI score and CRP/albumin ratio levels.
Conclusion: PNI scores were found to be significantly lower in patients who needed admission to the intensive care unit and died due to severe COVID-19 than the others. In patients with a low PNI score, COVID-19 can be more severe and it may cause worse clinical outcomes.
An analysis of the Diplomatic Situation of the First Czechoslovak Republic and its Impacts on the Nation’s Demise after the Munich Agreement
Authors: Guo Haolin 
Published: June 2022

Purpose: The objective of this research is to dive into the details of the First Czechoslovak Republic’s diplomacy and examine the impacts and significance of its diplomacy on its doomed national security.
Methodology: This article primarily used qualitative research methods. By studying official historical documents from governments, the historical circumstances could be analysed. Secondary sources, such as books written by historians were also referenced to view this period of history from unique perspectives.
Unique Contribution to this Field: Currently, most research about the First Czechoslovak Republic revolves around the time close to the Munich Agreement. This article innovatively studied the diplomatic history of Czechoslovakia since its formation and focused on its diplomacy in the 1920s.
ROMA SİYASETİNDE ASKERİ GÜÇ: AELİUS SEİANUS
Authors: TAŞDÖNER Kevser 
Published: June 2022

İS 14 yılında Roma’nın ikinci imparatoru olarak yönetime geçen Tiberius Claudius Nero, Caesar Augustus’tan güçlü ve sistemli bir yönetimi devraldı. Tiberius, üvey babasının yönetiminde dâhil zaman zaman Roma siyasetinden uzaklaşarak inzivaya çekilmesini kendi imparatorluğu döneminde de devam etti. Zira Tiberius’un inzivaya çekildiği bu zamanlarda, Praetor Praefectusu olan Aelius Seianus güçlenerek, önemli derecede nüfuz sahibi oldu. Seinaus için etkili bir nüfuz ise, Tiberius’tan sonra tahta çıkacak kimsenin olmaması durumunda, kendisinin Roma tahtına açılan kapının anahtarıydı. Onun bu konuda uygulayacağı taktik çok netti. Mevcut varisleri ortadan kaldırmak. Zira bu konuda karşısına çıkabilecek herkesi, ya da kendi prestijini sarsabilecek kişileri ağır yargılamalar, komplolar ve cezalarla bertaraf etmeyi başarabildi.
Praetor Praefectus taburlarını tek bir kalıcı kampta toplayarak Roma’daki asayiş gücünü büyük ölçüde güçlendiren Aelius Seianus, askerler üzerinde daha iyi bir disiplin kurulması konusunda çalışmalar yaptı. Fakat aynı zamanda Praetor Praefectuslarının kampını, siyasi tutuklular için kullandı. Aelius Seianus, söz konusu siyasi ve askeri gücü ile maiestas yasası kapsamında çok sayıda kişiyi suçlamalarda bulunarak yargılanmalarına sebep oldu. Hesabında olmayan son yargılaması ise, kendisine karşı açılan maiestas suçlamasıydı.
Oldukça başarılı komutanlar yetiştiren, askerliği ve savaşırken ölmeyi en büyük erdem olarak gören Roma Cumhuriyet yönetimi liderlerinden eser kalmamıştı. Büyüyen, güçlenen Roma İmparatorluğu artık saray entrikalarının yaşandığı, makam için insan katledildiği bir dönemi yaşıyordu. Bu konuda ilk bayrağı tutan Aelius Seianus oldu. Bu makalede amacımız, Aelius Seianus’un güçlenişini, yaptırımlarını Praetor Praefectus görevi kapsamında değerlendirmektir.
RELATO DE EXPERIENCIA: A BUSCA ATIVA DE MULHERES NA TRIAGEM DO CSF PADRE PALHANO/SOBRAL-CE PARA COLETA DE CITOPATOLOGICO
Authors: Araujo Regilania Parente de Albuquerque , CARNEIRO MARIA LARISSA SOARES , Dias Francisca Isaelly dos Santos , ARAUJO REGINA CLAUDIA MARIA DE 
Published: June 2022

Introdução: O câncer de colo uterino agride em especial mulheres na idade reprodutiva, e isso constitui grave problema de saúde pública, devido ao alto índice de mortalidade, provocada pelo diagnóstico tardio. Objetivo: Mostrar a importância de buscar mulheres de 25 a 64 anos na triagem da unidade básica de saúde de forma dinâmica e com metodologias ativas, com intuito de aumentar o índice de coletas de citopatologicos de mulheres que há mais de 2 anos não fazem o exame. Material e métodos: Trata-se de um relato de experiência, em um trabalho realizado no CSF Padre Palhano, Sobral/Ceara. Buscamos identificar as mulheres com exame de citopatologicos atrasados a mais de dois anos e que naquele momento comparecia a unidade para outro tipo de atendimento, e já era orientada a importância da coleta e realização do procedimento no mesmo dia. Assim ofertamos o serviço diariamente e sem agendamento, fazendo com que as mulheres tivesse melhor adesão ao exame.Resultados: Muitas mulheres se sentiram importantes e já aceitava a proposta de coletar o exame naquele momento, assim não perdia tempo outro dia para vim a unidade, também conseguimos reduzir assim a vergonha e preconceito que as mulheres sentem até mesmo por não conhecer corretamente o procedimento. Nossa cobertura de citopatologico teve uma melhora bem significativa, melhorando o nosso indicador.Conclusão: O processo de trabalho em um centro de saúde da Família tem papel importante junto a essa população, principalmente no que se refere à educação em saúde, de forma a mudar conceitos e conseguir ampla cobertura para a realização da prevenção. O gestor precisa aliar o conhecimento à prática, ter estrutura física, organização de trabalho adequada e oferecer atendimento humanizado às mulheres, sendo o acolhimento e a informação as principais estratégias de abordagem, de forma a obter adesão plena ao exame preventivo do câncer de colo uterino.
TROMBOSE VENOSA PROFUNDA ASSOCIADA À UTILIZAÇÃO INDISCRIMINADA DE CONTRACEPTIVO ORAL: UMA REVISÃO DE LITERATURA
Authors: Nascimento Klayver Cláudio do , RAMOS GABRIELA DA SILVA , QUINTAS JADE MARTINI , NASCIMENTO DÉBORA SILVA DO , SILVA JÚLIA MARIA DO NASCIMENTO 
Published: June 2022

Introdução: A busca por métodos para prevenir a gestação acompanha a sociedade desde os primórdios, entretanto, é possível afirmar que muitas mulheres vem começando a vida sexual cada vez mais cedo, sucedendo com a prática contraceptiva, na qual 66% das jovens entre 15 a 19 anos sexualmente ativas, já utilizam algum método contraceptivo, sendo eles o preservativo, a pílula e os injetáveis, os mais procurados segundo dados da pesquisa nacional de demografia e saúde da criança e da mulher (PNDS­). Contudo, como todo medicamento, a utilização indiscriminada de contraceptivos orais (CO’s), podem acarretar em riscos à saúde, tais como o aumento do risco de tromboembolismo venoso (TEV), incluindo trombose venosa profunda (TVP) e embolia pulmonar (EP). Objetivo: Este estudo tem como objetivo, identificar as principais consequências que o uso irracional de contraceptivos orais pode desencadear no organismo e seus agravamentos para a saúde da mulher. Métodos: Trata-se de uma revisão bibliográfica através de consulta a artigos científicos selecionados através de banco de dados eletrônicos, tais como Scientific Electronic Library Online (Sciello) e Pubmed, além de dados do Ministério da Saúde (MS), utilizando como descritores: trombose; contraceptivos orais; doenças cardiovasculares. A critério de inclusão, foram selecionados artigos compreendidos entre 2018-2021, além dos com acesso ao texto completo. Resultados: Os ACOs são medicamentos esteroidais que atuam bloqueando o eixo neuro-endócrino responsável pela regulação hipofisária dos níveis hormonais feminino. Além disso, segundo a literatura, os contraceptivos podem causar resistência às proteínas C-reativas, que são anticoagulantes naturais do organismo, que é evidenciado pela utilização irracional de contraceptivos combinados que consiste na associação de hormônios, tais como o estrogênio e a progesterona. Assim sendo, quem faz a utilização recorrente de maneira indiscriminada, sem acompanhamento de um profissional tem mais chances de desenvolver complicações trombóticas em consequência ao dano na homeostasia de coagulação sanguínea. Conclusão: Dessa forma, os riscos de trombolismo venoso em mulheres que fazem utilização de anticoncepcionais é 5 vezes maior, quando em comparação aos que não utilizam esse tipo de contracepção. Além disso, os riscos são ainda maiores quando utilizado de forma recorrente a longo prazo.
DESCRIÇÃO DOS EFEITOS DO EXERCÍCIO RESISTIDO NA MARCHA EM IDOSOS
Authors: Barbosa Vaildo Hilmo Pessôa , SILVA MARIA APARICIDA GOMES DA , SANTOS YURI FELIX DOS , CASTRO CLAUDIO RENATO OLIVEIRA BRANDÃO DE , RAMOS RENATA KALILE BARRETO 
Published: June 2022

Introdução: O envelhecimento da população é uma realidade desafiadora na sociedade com notória diminuição de força e da potência muscular causando impacto na rotina dos idosos. O treinamento resistido é aquele realizado contra uma resistência, seja essa uma carga opositora, o próprio peso corporal, resistência elástica ou resistência gravitacional levando a uma melhora no quadro de força e propriocepção. Esse tipo de treinamento envolve uma vasta gama de modalidades nas quais inserem-se exercícios corporais com pesos, uso de faixas elásticas, exercícios pliométricos e corrida em ladeiras. Um das maiores eficiências do exercício resistido é na marcha do idoso onde existe, então uma melhora nos aspectos funcionais que mais se altera com o passar dos anos. Objetivo: Descrever os benefícios do exercício resistido na marcha em idosos. Metodologia: Estudo de revisão bibliográfica, realizado nas bases de dados Google Acadêmico e Scielo. Foram selecionados cinco artigos publicados no ano de 2017 a 2021, na língua inglesa e portuguesa que destacassem os efeitos diretos da modalidade. Resultados e discussão: Foi percebido que esse quadro pode ser melhorado com a prática do exercício resistido, apresentando mais eficácia no desenvolvimento da hipertrofia muscular, trazendo melhorias na densidade óssea e oferecendo melhoras fisiológicas e biomecânicas de MMF e MMS em pessoas acima de 60 anos, além de beneficiar na longevidade e qualidade de vida do idoso. Conclusão: Conclui-se que as alterações fisiológicas presentes no processo de envelhecimento acarretando problemas na marcha do idoso, podem ser prevenidas e atenuadas com a prática regular de exercício físico, principalmente os resistidos, por possibilitarem o fortalecimento dos músculos das pernas e costas, melhorias dos reflexos e da sinergia motora das reações posturais, acréscimos na velocidade da marcha e aumento da flexibilidade.