bluuebunny/crossref_metadata_2025_split huggingface dataset:
Burnout in nursing: A vision of gender and “invisible” unrecorded care
Authors: Montañés Muro Mª Pilar , Ayala Calvo Juan Carlos , Manzano García Guadalupe 
Published: December 2022

AbstractAimTo reflect on how characteristics inherent in the nursing profession might be related to burnout syndrome among the nursing collective.BackgroundMost people are unaware of the tasks and responsibilities of the nursing profession, as well as the burnout rates suffered by nurses. The nursing profession is a feminized profession, and this feminization may lead to the assignment of gender stereotypes and roles traditionally attributed to women. Much of the care provided by nurses is unrecorded, “invisible” and could be seen as an extension of their role as caregivers.MethodsThis is a discussion paper. The literature on gender stereotypes, unrecorded (invisible) care in nursing and burnout are the argumentative basis of this work.DiscussionStereotypes and gender roles may explain the lack of recognition of some of the carework carried out by nurses. Care, which is the essence of the profession, continues to be largely invisible and is not valued. This lack of recognition of invisible care, coupled with gender stereotypes, may help to understand burnout syndrome in nursing.Impact for NursingHealth organizations should take into account the history of the nursing profession and the stereotypes associated with it. It is necessary to recognize and make visible much of the care provided by nurses which are not recorded (invisible care), since this would facilitate the visibilization of the workload and could reduce the possibility of suffering burnout. If we want quality care and staff who enjoy the greatest possible well‐being, it will be necessary to take these variables into consideration. One purpose should be: to care for them so that they can provide quality care to others.No Patient or Public ContributionThis is a discussion paper.
Using machine‐learning methods to identify early‐life predictors of 11‐year language outcome
Authors: Gasparini Loretta , Shepherd Daisy A. , Bavin Edith L. , Eadie Patricia , Reilly Sheena , Morgan Angela T. , Wake Melissa 
Published: December 2022

BackgroundLanguage is foundational for neurodevelopment and quality of life, but an estimated 10% of children have a language disorder at age 5. Many children shift between classifications of typical and low language if assessed at multiple times in the early years, making it difficult to identify which children will have persisting difficulties and benefit most from support. This study aims to identify a parsimonious set of preschool indicators that predict language outcomes in late childhood, using data from the population‐based Early Language in Victoria Study (n = 839).MethodsParents completed surveys about their children at ages 8, 12, 24, and 36 months. At 11 years, children were assessed using the Clinical Evaluation of Language Fundamentals 4th Edition (CELF‐4). We used random forests to identify which of the 1990 parent‐reported questions best predict children's 11‐year language outcome (CELF‐4 score ≤81 representing low language) and used SuperLearner to estimate the accuracy of the constrained sets of questions.ResultsAt 24 months, seven predictors relating to vocabulary, symbolic play, pragmatics and behavior yielded 73% sensitivity (95% CI: 57, 85) and 77% specificity (95% CI: 74, 80) for predicting low language at 11 years. [Corrections made on 5 May 2023, after first online publication: In the preceding sentence ‘motor skills’ has been corrected to ‘behavior’ in this version.] At 36 months, 7 predictors relating to morphosyntax, vocabulary, parent–child interactions, and parental stress yielded 75% sensitivity (95% CI: 58, 88) and 85% specificity (95% CI: 81, 87). Measures at 8 and 12 months yielded unsatisfactory accuracy.ConclusionsWe identified two short sets of questions that predict language outcomes at age 11 with fair accuracy. Future research should seek to replicate results in a separate cohort.
Preheating of dental composite resins: A scoping review
Authors: Patussi Amanda F. C. , Ramacciato Juliana C. , da Silva João G. R. , Nascimento Victória R. P. , Campos Débora e Silva , de Araújo Ferreira Munizz Isis , de Souza Grace M. , Lima Renally B. W. 
Published: December 2022

AbstractObjectiveThe aim of this scoping review was to analyze the available evidence on the preheating process and its effects on physicochemical properties of composite resins.Materials and MethodsA systematic search was performed in August 2021 using PubMed/Medline, Embase, Scopus, and ISI Web of Science databases and gray literature without language or date restriction. Inclusion criteria were in vitro studies that assessed the physicochemical properties and marginal adaptation of preheated composite. Exclusion criteria were studies with experimental composite, literature reviews, clinical studies. Data from selected studies were qualitatively analyzed.ResultsIn total, 104 studies were found from which 39 were included. The most used composite resin was Filtek Z350 XT (3 M/ESPE), preheated at 68°C in a Calset device (AdDent Inc., Danbury, CT, USA) for 5 or 15 min. Most studies showed decreased viscosity, increased conversion degree and microhardness of composite resins, and better marginal adaptation of direct and indirect restorations. Also, flexural strength was not affected, and data about bond strength were inconclusive due to heterogeneity among studies.ConclusionThe parameters used for preheating composite resins are heterogeneous. Preheating decreased viscosity, increased the conversion degree and microhardness of composite resins, and improved the marginal adaptation of direct and indirect restorations.Clinical SignificanceThe analysis of evidence showed a high heterogeneity among preheating protocols. Preheating may benefit the handling and physicochemical properties of composite resins.
From sneaker to bourgeois male: Long‐term observations on recognized tompot blenny Parablennius gattorugine individuals reveal new information on their biology
Authors: Naylor Paul , Naylor Teresa , Hammond Louise , Jacoby David M. P. 
Published: December 2022

AbstractThe behaviour of the tompot blenny Parablennius gattorugine was studied by underwater observation and photography on the south‐west coast of the UK over an 11 year period, with >50 individuals identified at two locations by their distinctive skin markings. Observations showed males engaging in rapid swimming behaviour when approached by a female, and younger males using alternative ‘sneaker’ tactics before becoming ‘bourgeois’ territory‐holders. The noninvasive recognition technique also facilitated detailed observations on territory retention (up to 7 years) and agonistic behaviours among both males and females.
Impact of persistent pain on function, cognition, and well‐being of older adults
Authors: Ritchie Christine Seel , Patel Kanan , Boscardin John , Miaskowski Christine , Vranceanu Ana‐Maria , Whitlock Elizabeth , Smith Alexander 
Published: December 2022

AbstractBackgroundWe sought to determine the population‐level associations between persistent pain and subsequent changes in physical function, cognitive function, and well‐being, outcomes important to older adults.MethodsWe used data from National Health Aging Trends Study (NHATS) of community‐dwelling Medicare beneficiaries age 65+ from 2011 to 2019. We defined “persistent pain” as being bothered by pain in the last month in both the 2011and 2012 interviews and “intermittent” pain including those reporting bothersome pain in one interview only. We used competing risks regression to estimate the association between persistent pain and the development of clinically meaningful declines in physical function, cognitive function, and well‐being, adjusting for age, sex, race, education, and marital status at baseline.ResultsOf the 5589 eligible NHATS participants, 38.7% reported persistent pain and 27.8% reported intermittent pain. Over one‐third described pain in five or more sites. Over the subsequent 7 years, participants with persistent pain were more likely to experience declines in physical function (64% persistent pain, 59% intermittent pain, 57% no bothersome pain; aHR 1.14, 95% CI 1.05–1.23) and well‐being (48% persistent pain, 45% intermittent pain, 44% no bothersome pain; aHR 1.11, 95% CI 1.01–1.21), but were not more likely to experience cognitive decline (25% persistent pain, 24% intermittent pain, 23% no bothersome pain; aHR 1.02, 95% CI 0.90–1.16).ConclusionsPersistent pain is common in older adults and occurs in multiple body sites. Persistent pain contributes to meaningful declines in physical function and well‐being over 7 years and warrants proactive interventions to mitigate pain.
Assessing the feasibility of using the ketogenic diet in autism spectrum disorder
Authors: Albers Jacob , Kraja Gearta , Eller Danielle , Eck Karen , McBrian Danielle , Bain Jennifer M. 
Published: December 2022

AbstractBackgroundEvidence demonstrating efficacy of dietary interventions for autism spectrum disorder (ASD) remains inconsistent. Recent research on the ketogenic diet (KD) for the treatment of ASD has suggested a benefit. Children with ASD often demonstrate ritualised food‐specific behaviours, taste and texture aversions, and an increased prevalence of food restrictions and allergies. There is a need to investigate how these features contribute to initiation and adherence of the KD. Two surveys were administered to assess the feasibility of utilising the KD for ASD.MethodsFirst, paper surveys were given to caregivers of children presenting to outpatient neurology clinics. Next, experienced clinicians were recruited and surveyed online using Qualtrics. Chi‐squared analysis was used to compare ASD and non‐ASD caregiver responses. Descriptive metrics were used to present clinician responses. Responses to each question were evaluated individually.ResultsOne hundred and fourteen surveys were collected from caregivers. There were no significant differences in (1) stated feasibility of adopting a new diet, (2) a carbohydrate restricted diet, (3) diet restrictions, (4) documented allergies or (5) personal/cultural restrictions between groups with and without ASD. Seventy clinician responses were collected. The majority (67.4%) indicated that feasibility for a child with ASD to adopt a KD for any reason depends on ASD severity. Some respondents 73% rated adherence to the KD as more difficult compared to age‐matched controls, whereas 26% considered it similar. Multiple familial and child characteristics were rated as increasing the difficulty of successful KD.ConclusionsThe results of the present study suggest that it is feasible for children with ASD to adopt a KD, and success is highly individualised to child and family.
High‐frequency repetitive magnetic stimulation rescues ischemia‐injured neurons through modulation of glial‐derived neurotrophic factor present in the astrocyteʼs secretome
Authors: Gava‐Junior Genilso , Ferreira Susana A. , Roque Cláudio , Mendes‐Oliveira Julieta , Serrenho Inês , Pinto Nuno , Patto Maria Vaz , Baltazar Graça 
Published: December 2022

AbstractDue to its ability to improve the most frequent clinical sequelae left by ischemia, repetitive transcranial magnetic stimulation has been considered a promising therapeutic strategy for stroke. Those improvements are associated with changes in neurons and their synaptic liaisons. However, the hypothesis that this technique modulates astrocytes, potentiating their neuroprotective capabilities, was also raised. This study aims to identify the effects triggered by high‐frequency repetitive magnetic stimulation (HF‐rMS) on astrocytes that contribute to its neuroprotective effects. Neuron–glia and astrocyte cortical cultures subject to oxygen and glucose deprivation were used as an in vitro model of ischemia. Neuroprotection promoted by HF‐rMS was evaluated by analysis of markers of neuronal activity and morphometric analysis of neurons. Glial reactivity was determined by immunocytochemistry. The levels of growth factors in the astrocyte‐conditioned medium (CM) were assessed through a Growth Factor Array and glial‐derived neurotrophic factor (GDNF) expression was analyzed by RT‐PCR and Western blot. Our results show that neurons injured by ischemia can be rescued through the modulation of astrocytes by HF‐rMS. This modulation helps to maintain the number and length of neurites and increases the number of neurons expressing ERK1/2 and c‐Fos. Analysis of the astrocyte‐CM showed that HF‐rMS stimulated the release of several trophic factors by astrocytes. Moreover, GDNF was one of the released factors that contributed to the recovery mechanisms triggered by HF‐rMS. Our results show that modulation of astrocytes by HF‐rMS effectively rescues neurons injured by ischemia and suggest that by targeting astrocytes this approach can also be used to promote neuroprotection in other brain lesions.image
Experiences and practices of mothers with children 0–5 age group on fever management: A mixed methods study
Authors: Göbekli Ayşe , Güney Rabiye 
Published: December 2022

AbstractAimsTo determine fever management experiences and practices of mothers of children between 0 and 5 years of age.BackgroundFever is a common child health challenge known since ancient times. The implications of poor fever management include emotional trauma in parents and the convulsions that might cause neurological sequelae in rare cases. However, even today, mothers' emotional experiences, support needs and psychosocial difficulties during the fever management process at home are not well known.DesignConvergent parallel mixed methods were used.MethodsQuestionnaire and Parent Fever Management Scale were applied to 170 mothers. 23 mothers were interviewed. ‘Number Cruncher Statistical System’ software and thematic analysis were used for data analysis. STROBE and COREQ checklist were utilized.ResultsThe mothers participating in the study reported that they had difficulty controlling their child's fever at home and 87.6% reported that they felt negative emotions during the process. Negative emotions were anxiety (83.3%), fear (67.3%), panic (34.7%), loneliness (14.3%), incompetence (21.3%), anger (0.7%), helplessness and guilt (2.7%). Sixty percent of the mothers stated that they couldn't easily reach a nurse for counselling when their child had a fever at home. In the qualitative part, five themes were identified as ‘meaning attributed to fever, psychosocial dimension of fever, fever management, difficulties in fever management, and fever within the scope of health service delivery’.ConclusionMothers still have difficulties in fever management at home. Nurses can support them with fever management programs either online or via telephone.Relevance to Clinical PracticeOur study shows that fever in children causes emotional problems as well as the burden of care among mothers. Mothers also need psychosocial and physical support during home‐based management of fever.Patient/Public ContributionOpinions were obtained from mothers about the qualitative findings and questions that will be included in the questionnaire and interviews.
Geographic distribution, conservation effectiveness, and gaps for national key protected wild plants in China
Authors: Qin Fei , Zhang Xiao‐Xia , Huang Yun‐Feng , Wu Lei , Xu Wei‐Bin , Xue Tian‐Tian , Zhang Wen‐Di , Liu Qin , Yu Jiang‐Hong , Gao Jie‐Jing , Bussmann Rainer W. , Wang Juan , Yu Sheng‐Xiang 
Published: December 2022

AbstractNational key protected wild plants (NKPWPs) are species with important conservation value based on genetics, ecology, culture, and/or scientific research, which are also confronted with serious threats. However, their geographical distribution patterns and conservation status remain unclear. In this study, we compiled 1032 species of NKPWPs. We measured the diversity to identify hotspots of NKPWPs based on species richness, weighted range size rarity and a complementarity‐based analysis. Comparing the distribution and hotspots of NKPWPs with the coverage of Chinese nature reserves (NRs), we assessed conservation effectiveness and identified conservation gaps. The results identified 13 diversity hotspots; only 9.5% of them were covered by NRs with >30% of the grid cell area, and even 19.5% were not covered at all by NRs. Overall, 44.7% of NKPWPs were effectively protected by national NRs. Despite this success, 571 species in Yunnan, Guizhou, Sichuan, Chongqing, Guangxi, Guangdong, southern Hainan, Taiwan, and northern Xinjiang remain unprotected by NRs. The protected proportion of plants with first‐level protection was lower than that of plants with second‐level protection. The low overall proportion of protected hotspots indicates that the conservation outlook for NKPWPs is not optimistic. This study identifies priority conservation areas and conservation gaps and provides a scientific reference for the conservation of wild plants in China.
Is the Catholic Church in America Experiencing Internal Secularization? Priests’ Assessments of Pope Francis and the Condition of the Church
Authors: Vermurlen Brad , Regnerus Mark , Cranney Stephen 
Published: December 2022

AbstractThis study addressed internal secularization in the Catholic Church by testing the role of several factors in priests’ assessments of the state of the Church in the United States, priests’ views of whether the Church's situation is getting better or worse, and their attitudes toward Pope Francis. Comparisons with identical questions fielded in 2002 revealed a striking pessimistic turn among priests over the last two decades. In addition, regression analyses using the 2021 Survey of American Catholic Priests revealed that “in‐house” factors—namely, attitudes toward Pope Francis and perceptions of how well bishops have restored confidence in the Catholic Church following the sexual abuse crisis—most powerfully predicted priests’ current pessimism. On top of this, politically conservative priests and priests ordained more recently tended to be most critical of how Francis is handling his duties, signaling a pronounced tension inside the Catholic Church over religious authority, a defining feature of internal secularization.
Examination of the pharmacokinetics and differential inhibition of cyclooxygenase isoenzymes in New Zealand white rabbits (Oryctolagus cuniculus) by the Non‐Steroidal anti‐inflammatory Robenacoxib
Authors: Jeffrey Alison , Gardhouse Sara , Kleinhenz Michael , Hocker Samuel E. , Weeder Mikaela , Montgomery Shawnee R. , Zhang Yuntao , Porting Anna , Rooney Tess 
Published: December 2022

AbstractEffective rabbit analgesia is challenging, and there are few studies available on the newer COX‐2 selective NSAIDs, such as robenacoxib. This study aimed to establish the pharmacokinetics of oral and subcutaneous robenacoxib, describe its inhibitory actions on COX enzymes, and develop dosing, using six healthy New Zealand white rabbits. Pharmacokinetics were determined from plasma concentrations after oral administration of robenacoxib (0.83–0.96 mg/kg) and also after subcutaneous administration (2 mg/kg). The inhibitory actions of robenacoxib were evaluated by measuring plasma concentrations of thromboxane B2 (TBX2) and prostaglandin E2 (PGE2) as surrogate markers of cyclooxygenase enzyme isoform inhibition. The mean maximum concentration for oral and subcutaneous administration was 0.23 μg/ml and 5.82 μg/ml, respectively. Oral robenacoxib administration did not demonstrate a significant difference between any time point for PGE2 or TBX2, though subcutaneous administration did for both. There was no significant difference in PGE2 or TBX2 concentrations at any time point when comparing subcutaneous versus oral routes. Although the results support that plasma robenacoxib exceeds the therapeutic levels compared to dogs and cats, there was little significance in the difference in the changes associated with COX‐1 and COX‐2 inhibition. Further studies are warranted to determine appropriate dosing, safety, and efficacy in rabbits.
Effect of intravesical tarantula cubensis extract (Theranekron) on inflammation in an interstitial cystitis rat model
Authors: Akdağ Abdullah , Yenisey Çiğdem , Epikmen Tuğrul E. , Ateş Erhan 
Published: December 2022

AbstractObjectivesTo reveal the histopathological and immunological outcomes of intravesical treatment with tarantula cubensis extract (TCE) in a rat model of interstitial cystitis.MethodsA total of 30 female Wistar albino rats were divided into three groups: group 1 (control group), group 2 (disease group), and group 3 (treatment group). The rat model of interstitial cystitis was created by biweekly intraperitoneal administration of cyclophosphamide (CYP). In group 3, TCE (a venom extracted from a brown spider known as tarantula cubensis) was administered intravesically after the model had been created. Urothelial degeneration, necrosis, ulcer, bleeding, edema, inflammation and mast cell count, interleukin‐6 (IL‐6), tumor necrosis factor‐alpha (TNF‐alpha), myeloperoxidase (MPO), and hydroxyproline parameters were evaluated. Statistical analysis was performed using one‐way analysis of variance, chi‐square tests, and Kruskal–Wallis tests.ResultsAll parameters were found to be lower in the rats in group 1 than in the other groups, and IL‐6 and MPO values were found to be higher in group 2 (p < .001). The mean TNF‐alpha value was highest in group 2 (p = .078). No difference was found between all groups regarding ulcer (p = .087). Urothelial degeneration, necrosis, edema, inflammation, hemorrhage and fibroblast proliferations, and hydroxyproline values were higher in group 3 (p < .001).ConclusionsIntravesical TCE instillation produces an anti‐inflammatory effect by reducing the levels of inflammatory parameters such as IL‐6, TNF‐alpha, and MPO in bladder tissue. It also accelerates tissue healing by increasing hydroxyproline and fibroblast proliferation.
Whole genome resequencing identifies local adaptation associated with environmental variation for redband trout
Authors: Andrews Kimberly R. , Seaborn Travis , Egan Joshua P. , Fagnan Matthew W. , New Daniel D. , Chen Zhongqi , Hohenlohe Paul A. , Waits Lisette P. , Caudill Christopher C. , Narum Shawn R. 
Published: December 2022

AbstractAquatic ectotherms are predicted to harbour genomic signals of local adaptation resulting from selective pressures driven by the strong influence of climate conditions on body temperature. We investigated local adaptation in redband trout (Oncorhynchus mykiss gairdneri) using genome scans for 547 samples from 11 populations across a wide range of habitats and thermal gradients in the interior Columbia River. We estimated allele frequencies for millions of single nucleotide polymorphism loci (SNPs) across populations using low‐coverage whole genome resequencing, and used population structure outlier analyses to identify genomic regions under divergent selection between populations. Twelve genomic regions showed signatures of local adaptation, including two regions associated with genes known to influence migration and developmental timing in salmonids (GREB1L, ROCK1, SIX6). Genotype–environment association analyses indicated that diurnal temperature variation was a strong driver of local adaptation, with signatures of selection driven primarily by divergence of two populations in the northern extreme of the subspecies range. We also found evidence for adaptive differences between high‐elevation desert vs. montane habitats at a smaller geographical scale. Finally, we estimated vulnerability of redband trout to future climate change using ecological niche modelling and genetic offset analyses under two climate change scenarios. These analyses predicted substantial habitat loss and strong genetic shifts necessary for adaptation to future habitats, with the greatest vulnerability predicted for high‐elevation desert populations. Our results provide new insight into the complexity of local adaptation in salmonids, and important predictions regarding future responses of redband trout to climate change.