bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilization of Immunotherapy in Patients with Cancer Treated in Routine Care Settings: A Population-Based Study Using Health Administrative Data
Authors: Raphael Jacques , Richard Lucie , Lam Melody , Blanchette Phillip S , Leighl Natasha B , Rodrigues George , Trudeau Maureen E , Krzyzanowska Monika K 
Published: April 2022

Abstract

Introduction
The introduction of immunotherapy (IO) in the treatment of patients with cancer has significantly improved clinical outcomes. Population level information on actual IO utilization is limited.

Methods
We conducted a retrospective cohort study using provincial health administrative data from Ontario, Canada to: (1) assess the extent of IO use from 2011 (pre-IO funding) to 2019; and (2) identify factors associated with IO use in patients with advanced cancers for which IO is reimbursed including melanoma, bladder, lung, head and neck, and kidney tumors. The datasets were linked using a unique encoded identifier. A Fine and Gray regression model with death as a competing risk was used to identify factors associated with IO use.

Results
Among 59 510 patients assessed, 8771 (14.7%) received IO between 2011 and 2019. Use of IO increased annually from 2011 (3.3%) to 2019 (39.2%) and was highest in melanoma (52%) and lowest in head and neck cancer (6.6%). In adjusted analysis, factors associated with lower IO use included older age (hazard ratio (HR) 0.91 (95% CI, 0.89-0.93)), female sex (HR 0.85 (95% CI, 0.81-0.89)), lower-income quintile, hospital admission (HR 0.78 (95% CI, 0.75-0.82)), high Charlson score and de novo stage 4 cancer. IO use was heterogeneous across cancer centers and regions.

Conclusion
IO utilization for advanced cancers rose substantially since initial approval albeit use is associated with patient characteristics and system-level factors even in a universal healthcare setting. To optimize IO utilization in routine practice, survival estimates and potential inequity in access should be further investigated and addressed.
Age-structured model reveals prolonged immigration is key for colony establishment in Gentoo Penguins
Authors: Herman Rachael W , Lynch Heather J 
Published: April 2022

AbstractUnderstanding the mechanisms of site colonization and range expansion is crucial to understanding population dynamics, particularly for colonial seabirds that may struggle to shift their breeding ranges under climate change. We provide an alternative and simple approach to estimating the number of migrating individuals among colonies when original mark–recapture datasets are not available for use in more integrated and established methods. Here we fit an age-structured population model with published vital rates and breeding success rates to simple point counts of abundance using rejection-based approximate Bayesian computation (ABC) to estimate the contribution of immigration to four recently colonized Gentoo Penguin (Pygoscelis papua) breeding sites on the Western Antarctic Peninsula. We found that sustained immigration over several years was required to generate the rapid population growth observed, with some sites even showing evidence of an accelerating immigration rate following initial colonization. We demonstrate that our method is capable of estimating the contribution of immigration to population growth in a species where mark–recapture datasets are unavailable. By leveraging census data that are relatively easy to obtain, our approach provides a new method for understanding how range expansions occur in species such as Antarctic penguins whose habitat is undergoing changing climate conditions.
Strong migratory connectivity indicates Willets need subspecies-specific conservation strategies
Authors: Huysman Allison E , Cooper Nathan W , Smith Joseph A , Haig Susan M , Heath Susan A , Johnson Luanne , Olson Elizabeth , Regan Kevin , Wilson Jennifer K , Marra Peter P 
Published: April 2022

AbstractBy combining all available banding and tracking data, we found that Willets (Tringa semipalmata) have a strong migratory connectivity between breeding and nonbreeding locations at the range-wide and subspecies levels, exposing two subspecies to varying threats such as hunting for the eastern subspecies (Tringa semipalmata semipalmata) and climatically-altered coastal habitats for both subspecies. We found that western Willets (Tringa semipalmata inornata) primarily used nonbreeding habitats along the Pacific Coast of the United States, although their reported nonbreeding range extends to the US Atlantic and Gulf Coasts and the Pacific Coast of Central and South America. Eastern Willets wintered in Central and South America, which covers much of the subspecies’ known nonbreeding range. By quantifying migratory connectivity within and between two subspecies, we could suggest subspecies-specific threats and potential limiting factors in the breeding and nonbreeding periods of the annual cycle of a declining migratory shorebird. Effective management of the species will likely require a range of conservation strategies across the diverse nonbreeding regions the two subspecies occupy within the United States, Central America, and South America. However, more data are needed from Willets breeding in mid-continental North America to understand the complete extent of overlap of the two subspecies throughout the annual cycle. The strong migratory connectivity documented here highlights the need to manage Willets by subspecies and protect a diversity of breeding and nonbreeding habitats, which will benefit the conservation of other shorebird species that overlap with Willets throughout the annual cycle.
Old challenges, new solutions: getting major projects right in the twenty-first century
Authors: Ansar Atif 
Published: April 2022

Abstract
Major projects are high-value (£100 million+) investments across sectors such as transport, energy, health, defence, or IT systems. Globally, a significant proportion of government policy initiatives are delivered through major projects. There is, however, a paradox at the heart of the major project phenomenon. Although major projects are indispensable tools for turning policy ideals into reality, their track record is strikingly poor. Cost and time overruns, financial engineering, under-supply, poor service, environmental detriment, and social dissatisfaction blight major projects. Poor outcomes have been a feature of the wide array of delivery mechanisms deployed over the past 150 years, including direct public provision, regulated private provision, public–private partnerships, and concessions, agreements, and franchises. The papers in this issue of the Oxford Review of Economic Policy explore the nature of this paradox and offer strategies designed to get major projects right, including repeatable platform strategies; mission-orientated investments; and deliberative and collaborative incentive schemes.
Splicing-mediated activation of SHAGGY-like kinases underpinning carbon partitioning in Arabidopsis seeds
Authors: Li Chengxiang , Chen Bin , Yu Hao 
Published: April 2022

Abstract
Glycogen synthase kinase 3 (GSK3) family members serve as signaling hubs for plant development and stress responses, yet the underlying mechanism of their transcriptional regulation remains a long-standing mystery. Here we show that the transcription of SHAGGY-like kinase 11/12 (SK11/12), two members of the GSK3 gene family, is promoted by the splicing factor SmD1b, which is essential for distributing carbon sources into storage and protective components in Arabidopsis seeds. The chromatin recruitment of SmD1b at the SK11/12 loci promotes their transcription associated with co-transcriptional splicing of the first introns in the 5′-untranslated region of SK11/12. The loss of SmD1b function generates transcripts with unspliced introns that create disruptive R-loops to hamper the transcriptional elongation of SK11/12, in addition to compromising the recruitment of RNA polymerase II to the SK11/12 genomic regions. These effects imposed by SmD1b determine the transcription of SK11/12 to confer a key switch of carbon flow among metabolic pathways in zygotic and maternal tissues in seeds.
Integrated omics reveal novel functions and underlying mechanisms of the receptor kinase FERONIA inArabidopsis thaliana
Authors: Wang Ping , Clark Natalie M , Nolan Trevor M , Song Gaoyuan , Bartz Parker M , Liao Ching-Yi , Montes-Serey Christian , Katz Ella , Polko Joanna K , Kieber Joseph J , Kliebenstein Daniel J , Bassham Diane C , Walley Justin W , Yin Yanhai , Guo Hongqing 
Published: April 2022

AbstractThe receptor kinase FERONIA (FER) is a versatile regulator of plant growth and development, biotic and abiotic stress responses, and reproduction. To gain new insights into the molecular interplay of these processes and to identify new FER functions, we carried out quantitative transcriptome, proteome, and phosphoproteome profiling of Arabidopsis (Arabidopsis thaliana) wild-type and fer-4 loss-of-function mutant plants. Gene ontology terms for phytohormone signaling, abiotic stress, and biotic stress were significantly enriched among differentially expressed transcripts, differentially abundant proteins, and/or misphosphorylated proteins, in agreement with the known roles for FER in these processes. Analysis of multiomics data and subsequent experimental evidence revealed previously unknown functions for FER in endoplasmic reticulum (ER) body formation and glucosinolate biosynthesis. FER functions through the transcription factor NAI1 to mediate ER body formation. FER also negatively regulates indole glucosinolate biosynthesis, partially through NAI1. Furthermore, we found that a group of abscisic acid (ABA)-induced transcription factors is hypophosphorylated in the fer-4 mutant and demonstrated that FER acts through the transcription factor ABA INSENSITIVE5 (ABI5) to negatively regulate the ABA response during cotyledon greening. Our integrated omics study, therefore, reveals novel functions for FER and provides new insights into the underlying mechanisms of FER function.
transcranial Direct Current Stimulation (tDCS) for the treatment and investigation of Phantom Limb Pain (PLP)
Authors: Damercheli Shahrzad , Ramne Malin , Ortiz-Catalan Max 
Published: April 2022

Abstract
Phantom limb pain (PLP) is a complex medical condition that is often difficult to treat, and thus can become detrimental to patients’ quality of life. No standardized clinical treatments exist and there is no conclusive understanding of the underlying mechanisms causing it. Noninvasive brain stimulation (NIBS) has been used to find correlations between changes in brain activity and various brain conditions, including neurological disease, mental illnesses, and brain disorders. Studies have also shown that NIBS can be effective in alleviating pain. Here, we examined the literature on a particular type of NIBS, known as transcranial direct current stimulation (tDCS), and its application to the treatment of PLP. We first discuss the current hypotheses on the working mechanism of tDCS and then we examine published evidence of its efficacy to treat PLP. We conclude this article by discussing how tDCS alone, and in combination with brain imaging techniques such as electroencephalography (EEG) and magnetic resonance imagining, could be applied to further investigate the mechanisms underlying PLP.
Association between accuracy of weight perception and life satisfaction among adults with and without anxiety and mood disorders: a cross-sectional study of the 2015–2018 Canadian Community Health Survey
Authors: Hadwen Brook , He Jennifer , Funk Celine , McKinney Kelly , Wilk Piotr 
Published: April 2022

Abstract

Background
Weight status and weight perception have a significant impact on life satisfaction. As overweight prevalence increases in Canada, it is important to understand how accuracy of weight perception (AWP) is associated with life satisfaction. This study explored the association between AWP and life satisfaction among Canadian adults with and without anxiety and/or mood disorders.

Methods
Using data from the 2015–2018 cycles of the Canadian Community Health Survey, an indicator of AWP was created to capture concordance between perceived weight and actual weight status. Univariate and multivariate Gaussian generalized linear models were assessed while stratifying by sex and presence of anxiety and/or mood disorders.

Results
Our sample included 88 814 males and 106 717 females. For both sexes, perceiving oneself as overweight or underweight, regardless of actual weight status, was associated with lower life satisfaction (β = −0.93 to −0.30), compared to those who accurately perceived their weight as ‘just about right’. Perceiving oneself as overweight or underweight was associated with more pronounced differences in life satisfaction scores in those with anxiety and/or mood disorders (β = −1.49 to −0.26) than in those without these disorders (β = −0.76 to −0.25).

Conclusion
Weight perception is more indicative of life satisfaction than actual weight status, especially in those with anxiety and/or mood disorders.
Does Welfare Prevent Crime? the Criminal Justice Outcomes of Youth Removed from Ssi
Authors: Deshpande Manasi , Mueller-Smith Michael 
Published: April 2022

Abstract
We estimate the effect of losing Supplemental Security Income (SSI) benefits at age 18 on criminal justice and employment outcomes over the next two decades. To estimate this effect, we use a regression discontinuity design in the likelihood of being reviewed for SSI eligibility at age 18 created by the 1996 welfare reform law. We evaluate this natural experiment with Social Security Administration data linked to records from the Criminal Justice Administrative Records System. We find that SSI removal increases the number of criminal charges by a statistically significant 20% over the next two decades. The increase in charges is concentrated in offenses for which income generation is a primary motivation (60% increase), especially theft, burglary, fraud/forgery, and prostitution. The effect of SSI removal on criminal justice involvement persists more than two decades later, even as the effect of removal on contemporaneous SSI receipt diminishes. In response to SSI removal, youth are twice as likely to be charged with an illicit income-generating offense than they are to maintain steady employment at ${\$}$15,000/year in the labor market. As a result of these charges, the annual likelihood of incarceration increases by a statistically significant 60% in the two decades following SSI removal. The costs to taxpayers of enforcement and incarceration from SSI removal are so high that they nearly eliminate the savings to taxpayers from reduced SSI benefits.
Non-hyperbolicity of the inviscid Cattaneo–Christov system for compressible fluid flow in several space dimensions
Authors: Angeles Felipe 
Published: April 2022

SummaryWe consider the coupling between the equations of motion of a compressible fluid in two and three space dimensions with Christov’s equation for the heat flux. Christov’s equation is a frame indifferent formulation of the classical model of Cattaneo that allows for the heat flux to be eliminated to obtain a single hyperbolic equation for the temperature. The obtained system is written in quasilinear form for the state variables density, velocity, temperature and heat flux. It is then shown that this system is not of hyperbolic type as a consequence of the presence of the Lie–Oldroyd upper-convected material derivative involved in Christov’s formulation.
Low-lying zeros in families of holomorphic cusp forms: the weight aspect
Authors: Devin Lucile , Fiorilli Daniel , Södergren Anders 
Published: April 2022

Abstract
We study low-lying zeros of L-functions attached to holomorphic cusp forms of level 1 and large even weight. In this family, the Katz–Sarnak heuristic with orthogonal symmetry type was established in the work of Iwaniec, Luo and Sarnak for test functions ϕ satisfying the condition supp$(\widehat \phi) \subset(-2,2)$. We refine their density result by uncovering lower-order terms that exhibit a sharp transition when the support of $\widehat \phi$ reaches the point 1. In particular, the first of these terms involves the quantity $\widehat \phi(1)$ which appeared in the previous work of Fouvry–Iwaniec and Rudnick in symplectic families. Our approach involves a careful analysis of the Petersson formula and circumvents the assumption of the Generalized Riemann Hypothesis (GRH) for higher-degree automorphic L-functions. Finally, when supp$(\widehat \phi)\subset (-1,1)$ we obtain an unconditional estimate which is significantly more precise than the prediction of the L-functions ratios conjecture.
Creating evaluative homogeneity: Experience of constructing a national journal ranking
Authors: Krzeski Jakub , Szadkowski Krystian , Kulczycki Emanuel 
Published: April 2022

Abstract
The study investigates the process of creating evaluative homogeneity within a performance-based research funding system. It does so in reference to the experience of creating a national journal ranking in Poland in 2019. It refers to the cases of two disciplines: biology and history. The use of this case is justified by its unique character, that is creating the ranking through means of both bibliometric indicators and expert panels. We therefore asked: What guided the actors who participated in the process of creating the ranking through the use of bibliometric indicators when introducing changes to its initial form? To answer this question, a mixed-methods approach was used. First, we conducted a quantitative analysis of changes made to the ranking during the consecutive steps of its creation. Second, we conducted a qualitative analysis of semi-structured interviews regarding actors’ motivations. By reflecting on the qualitative analysis along with the results of the quantitative part, this study reveals the extent to which actors impacted the form evaluative homogeneity took within the system. It further argues that this is dictated by how actors position themselves in relation to two opposing forces: those favouring the homogenization of research and those maintaining its heterogeneity. As these forces remain imbalanced, the study concludes with a call for further exploration of the interplay between the forces of homogenization and heterogenization and how the tensions between them are mediated within a performance-based research funding system.
A World Equilibrium Model of the Oil Market
Authors: Bornstein Gideon , Krusell Per , Rebelo Sergio 
Published: April 2022

Abstract
We use new, comprehensive micro data on oil fields to build and estimate a structural model of the oil industry embedded in a general equilibrium model of the world economy. In the model, firms that belong to Organization of the Petroleum Exporting Countries (OPEC) act as a cartel. The remaining firms are a competitive fringe. We use the model to study the macroeconomic impact of the advent of fracking. Fracking weakens the OPEC cartel, leading to a large long-run decline in oil prices. Fracking also reduces the volatility of oil prices in the long run because fracking firms can respond more quickly to changes in oil demand.
Slicing the Pie: Quantifying the Aggregate and Distributional Effects of Trade
Authors: Galle Simon , Rodríguez-Clare Andrés , Yi Moises 
Published: April 2022

AbstractWe develop a multi-sector gravity model with heterogeneous workers to quantify the aggregate and group-level welfare effects of trade. The model generalizes the specific-factors intuition to a setting with labour reallocation, leads to a parsimonious formula for the group-level welfare effects from trade, and nests the aggregate results in Arkolakis, Costinot and Rodríguez-Clare (2012, “New Trade Models, Same Old Gains?”, American Economic Review, 102, 94–130). We estimate the model using the structural relationship between China-shock driven changes in manufacturing employment and average earnings across US groups defined as commuting zones. We find that the China shock increases average welfare but some groups experience losses as high as four times the average gain. However, adjusting for plausible measures of inequality aversion barely affects the welfare gains. We also develop and estimate an extension of the model that endogenizes labour force participation and unemployment, finding similar welfare effects from the China shock.
CESIUM-RICH MICROPARTICLES RUNOFF DURING RAINFALL: A CASE STUDY IN THE TAKASE RIVER
Authors: Tatsuno Takahiro , Waki Hiromichi , Kakuma Minato , Nihei Naoto , Wada Toshihiro , Yoshimura Kazuya , Nakanishi Takahiro , Ohte Nobuhito 
Published: April 2022

Abstract
Cesium-rich microparticles (CsMPs) with high cesium-137 (137Cs) concentrations were released and deposited in surface soil after the Fukushima Daiichi Nuclear Power Plant accident. Radioactive materials on the soil surface layer enter rivers owing to soil erosion during rainfall. In this study, we investigated CsMPs runoff through the river via soil erosion during rainfall in the Takase River watershed in Namie Town, Fukushima Prefecture, Japan. CsMPs were rarely detected in suspended solids (SS) in water samples collected during four rainfalls between February and July 2021. Furthermore, the proportion of 137Cs concentration derived from CsMPs to 137Cs concentration in the form of SS (particulate 137Cs) in the water was ~6% on average, which suggests that 137Cs runoff in the form of CsMPs from the forest to the Takase River was not large.
DISTRIBUTIONS OF 210PB, 137CS AND PHYSICAL PROPERTIES IN BOTTOM SEDIMENTS OF WEST NANAO BAY, JAPAN
Authors: Ochiai Shinya , Fujita Atsushi , Tokunari Takeo , Sakai Hideo , Nagao Seiya 
Published: April 2022

Abstract
This study revealed sedimentation processes based on 137Cs and 210Pb distribution, grain size and magnetic susceptibility of bottom sediments in West Nanao Bay, Japan. Surface sediment concentrations and inventories of these radionuclides were relatively low in the middle and eastern areas of the bay and high in the western area, which has several major river mouths, suggesting that the contribution of riverine input affected only the western area. In the middle and eastern areas, the level of 137Cs inventory was much lower than that of the soils, and the excess 210Pb inventory was at the same level or lower. These results indicate that removal effects are stronger than accumulation effects (riverine input) in these areas. The patterns of radionuclides were consistent with the results, that grain size was relatively large in the middle and eastern areas, implying strong current conditions, and that fine sediment accumulated less in these areas.
LEVELS OF ATMOSPHERIC TRITIUM IN THE SITE OF FUSION TEST FACILITY
Authors: Tanaka Masahiro , Iwata Chie , Nakada Miki , Kato Akemi , Akata Naofumi 
Published: April 2022

Abstract
In the deuterium plasma experiment using Large Helical Device at the National Institute for Fusion Science (NIFS), a small amount of tritium is produced by the D–D fusion reaction. Then, a part of produced tritium is discharged into the environment via a stack. Thus, the atmospheric tritium in the site of NIFS has been monitored before starting the deuterium plasma experiment. The atmospheric tritium concentrations at NIFS were indicated to be background levels in Japan. To investigate the impact of tritium discharged from the stack, the correlation between the atmospheric tritium concentration and the tritium concentration observed in the stack was evaluated, and no significant correlation was found. In addition, the atmospheric tritium concentration at NIFS ranged within the background levels in Japan. Therefore, the impact of discharged tritium from the stack would be negligible in the environment at NIFS.