bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invasive fungal diseases impact on outcome of childhood ALL – an analysis of the international trial AIEOP-BFM ALL 2009
Authors: Lehrnbecher Thomas , Groll Andreas H. , Cesaro Simone , Alten Julia , Attarbaschi Andishe , Barbaric Draga , Bodmer Nicole , Conter Valentino , Izraeli Shai , Mann Georg , Möricke Anja , Niggli Felix , Schrappe Martin , Stary Jan , Zapotocka Ester , Zimmermann Martin , Elitzur Sarah 
Published: December 2022

AbstractIn children with acute lymphoblastic leukemia (ALL), risk groups for invasive fungal disease (IFD) with need for antifungal prophylaxis are not well characterized, and with the advent of new antifungal compounds, current data on outcome are scarce. Prospectively captured serious adverse event reports of children enrolled in the international, multi-center clinical trial AIEOP-BFM ALL2009 were screened for proven/probable IFD, defined according to the updated EORTC/MSG consensus definitions. In a total of 6136 children (median age 5.2 years), 224 proven/probable IFDs (65 yeast and 159 mold) were reported. By logistic regression, the risk for proven/probable IFDs was significantly increased in children ≥12 years and those with a blast count ≥10% in the bone marrow on day 15 (P < 0.0001 each). Proven/probable IFDs had a 6-week and 12-week mortality of 10.7% and 11.2%, respectively. In the multivariate analysis, the hazard ratio for event-free and overall survival was significantly increased for proven/probable IFD, age ≥12 years, and insufficient response to therapy (P < 0.001, each). Our data define older children with ALL and those with insufficient treatment-response at high risk for IFD. As we show that IFD is an independent risk factor for event-free and overall survival, these patients may benefit from targeted antifungal prophylaxis.
A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients
Authors: Massacci Giorgia , Venafra Veronica , Latini Sara , Bica Valeria , Pugliese Giusj Monia , Graziosi Simone , Klingelhuber Felix , Krahmer Natalie , Fischer Thomas , Mougiakakos Dimitrios , Boettcher Martin , Perfetto Livia , Sacco Francesca 
Published: December 2022

AbstractThe insertion site of the internal tandem duplications (ITDs) in the FLT3 gene affects the sensitivity to tyrosine kinase inhibitors (TKIs) therapy in acute myeloid leukemia (AML). Patients with the ITD in the tyrosine kinase domain lack effective therapeutic options. Here, to identify genotype-driven strategies increasing the TKI therapy efficacy, we developed SignalingProfiler, a strategy supporting the integration of high-sensitive mass spectrometry-based (phospho)proteomics, RNA sequencing datasets with literature-derived signaling networks. The approach generated FLT3-ITD genotype-specific predictive models and revealed a conserved role of the WEE1-CDK1 axis in TKIs resistance. Remarkably, pharmacological inhibition of the WEE1 kinase synergizes and strengthens the pro-apoptotic effect of TKIs therapy in cell lines and patient-derived primary blasts. Finally, we propose a new molecular mechanism of TKIs resistance in AML and suggest the combination of WEE1 inhibitor and TKI as a therapeutic option to improve patients clinical outcome.
The role of PPARγ in prostate cancer development and progression
Authors: Hartley Andrew , Ahmad Imran 
Published: December 2022

AbstractAdvanced and metastatic prostate cancer is often incurable, but its dependency on certain molecular alterations may provide the basis for targeted therapies. A growing body of research has demonstrated that peroxisome proliferator-activated receptor gamma (PPARγ) is amplified as prostate cancer progresses. PPARγ has been shown to support prostate cancer growth through its roles in fatty acid synthesis, mitochondrial biogenesis, and co-operating with androgen receptor signalling. Interestingly, splice variants of PPARγ may have differing and contrasting roles. PPARγ itself is a highly druggable target, with agonists having been used for the past two decades in treating diabetes. However, side effects associated with these compounds have currently limited clinical use of these drugs in prostate cancer. Further understanding of PPARγ and novel techniques to target it, may provide therapies for advanced prostate cancer.
An RNA-targeting CRISPR–Cas13d system alleviates disease-related phenotypes in Huntington’s disease models
Authors: Morelli Kathryn H. , Wu Qian , Gosztyla Maya L. , Liu Hongshuai , Yao Minmin , Zhang Chuangchuang , Chen Jiaxu , Marina Ryan J. , Lee Kari , Jones Krysten L. , Huang Megan Y. , Li Allison , Smith-Geater Charlene , Thompson Leslie M. , Duan Wenzhen , Yeo Gene W. 
Published: December 2022

AbstractHuntington’s disease (HD) is a fatal, dominantly inherited neurodegenerative disorder caused by CAG trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Since the reduction of pathogenic mutant HTT messenger RNA is therapeutic, we developed a mutant allele-sensitive CAGEX RNA-targeting CRISPR–Cas13d system (Cas13d–CAGEX) that eliminates toxic CAGEX RNA in fibroblasts derived from patients with HD and induced pluripotent stem cell-derived neurons. We show that intrastriatal delivery of Cas13d–CAGEX via an adeno-associated viral vector selectively reduces mutant HTT mRNA and protein levels in the striatum of heterozygous zQ175 mice, a model of HD. This also led to improved motor coordination, attenuated striatal atrophy and reduction of mutant HTT protein aggregates. These phenotypic improvements lasted for at least eight months without adverse effects and with minimal off-target transcriptomic effects. Taken together, we demonstrate proof of principle of an RNA-targeting CRISPR–Cas13d system as a therapeutic approach for HD, a strategy with implications for the treatment of other dominantly inherited disorders.
Microwave-assisted synthesis of biodiesel by a green carbon-based heterogeneous catalyst derived from areca nut husk by one-pot hydrothermal carbonization
Authors: Yadav Gaurav , Yadav Nidhi , Ahmaruzzaman Md. 
Published: December 2022

AbstractIn this study, we have synthesized a solid acid catalyst by areca nut husk using low temperature hydrothermal carbonization method. The fabricated catalyst has enhanced sulfonic actives sites (3.12%) and high acid density (1.88 mmol g−1) due to –SO3H, which are used significantly for effective biodiesel synthesis at low temperatures. The chemical composition and morphology of the catalyst is determined by various techniques, such as Fourier transform infrared (FTIR), powder X-ray diffraction (XRD), Brunauer–Emmett–Teller (BET), Scanning electron microscope (SEM), Energy disruptive spectroscopy (EDS), Mapping, Thermogravimetric analysis (TGA), CHNS analyzer, Transmission electron microscopy (TEM), particle size analyzer, and X-ray photoelectron spectroscopy (XPS). Acid–base back titration method was used to determine the acid density of the synthesized material. In the presence of the as-fabricated catalyst, the conversion of oleic acid (OA) to methyl oleate reached 96.4% in 60 min under optimized conditions (1:25 Oleic acid: methanol ratio, 80 °C, 60 min, 9 wt% catalyst dosage) and observed low activation energy of 45.377 kJ mol−1. The presence of the porous structure and sulfonic groups of the catalyst contributes to the high activity of the catalyst. The biodiesel synthesis was confirmed by gas-chromatography mass spectrometer (GC–MS) and Nuclear magnetic resonance (NMR). The reusability of the catalyst was examined up to four consecutive cycles, yielding a high 85% transformation of OA to methyl oleate on the fourth catalytic cycle.
An improved prognostic model for predicting the mortality of critically ill patients: a retrospective cohort study
Authors: Zhang Xianming , Yang Rui , Tan Yuanfei , Zhou Yaoliang , Lu Biyun , Ji Xiaoying , Chen Hongda , Cai Jinwen 
Published: December 2022

AbstractA simple prognostic model is needed for ICU patients. This study aimed to construct a modified prognostic model using easy-to-use indexes for prediction of the 28-day mortality of critically ill patients. Clinical information of ICU patients included in the Medical Information Mart for Intensive Care III (MIMIC-III) database were collected. After identifying independent risk factors for 28-day mortality, an improved mortality prediction model (mionl-MEWS) was constructed with multivariate logistic regression. We evaluated the predictive performance of mionl-MEWS using area under the receiver operating characteristic curve (AUROC), internal validation and fivefold cross validation. A nomogram was used for rapid calculation of predicted risks. A total of 51,121 patients were included with 34,081 patients in the development cohort and 17,040 patients in the validation cohort (17,040 patients). Six predictors, including Modified Early Warning Score, neutrophil-to-lymphocyte ratio, lactate, international normalized ratio, osmolarity level and metastatic cancer were integrated to construct the mionl-MEWS model with AUROC of 0.717 and 0.908 for the development and validation cohorts respectively. The mionl-MEWS model showed good validation capacities with clinical utility. The developed mionl-MEWS model yielded good predictive value for prediction of 28-day mortality in critically ill patients for assisting decision-making in ICU patients.
The Anti-inflammatory Effects of Isoflavonoids from Radix Astragali in Hepatoprotective Potential against LPS/D-gal-induced Acute Liver Injury
Authors: Aobulikasimu Nuerbiye , Zheng Dan , Guan Peipei , Xu Lixiao , Liu Bo , Li Minglei , Huang Xueshi , Han Li 
Published: December 2022

AbstractRadix Astragali (RA) is an important Traditional Chinese Medicine widely used in the treatment of various diseases, such as pneumonia, atherosclerosis, diabetes, kidney and liver fibrosis.
The role of isoflavonoids from RA in the treatment of liver injury remains unclear. The study aimed to explore hepatoprotective and anti-inflammatory effects of isoflavonoids from
Astragalus mongholicus. Network pharmacological analysis showed that RA had a multi-target regulating effect on alleviating liver injury and inhibiting inflammation through its active
ingredients, among which isoflavones were closely related to its key molecular targets. The anti-inflammatory and liver protection effects of isoflavonoids of RA were investigated using
lipopolysaccharide (LPS)-induced RAW 264.7 cells in vitro and LPS/D-galactosamine (D-gal)-induced acute liver injury mice in vivo. The experimental results showed that
methylnissolin (ML) and methylnissolin-3-O-β-D-glucoside (MLG) presented more notable anti-inflammatory effects. Both of them suppressed the release of pro-inflammatory cytokines,
such as iNOS, COX-2, IL-1β, IL-6, and TNF-α in LPS-stimulated RAW 264.7 cells. In vivo investigation demonstrated that ML markedly meliorated liver injury in
LPS/D-gal-induced mice. Western blot results revealed that ML and MLG down-regulated the expression of proinflammatory cytokines via NF-κB signaling pathway. The isoflavonoids,
methylnissolin (ML), and methylnissolin-3-O-β-D-glucoside (MLG), play a vital role in the hepatoprotective and anti-inflammatory effects of RA.
Inverse Cherenkov dielectric laser accelerator for ultra-relativistic particles
Authors: Zhang Liwen , Liu Weihao , Liu Yucheng , Jia Qika , Sun Baogen , Xu Hongliang , Liu Shengguang 
Published: December 2022

Abstract
Recently, the laser-driven dielectric particle accelerator based on the inverse Cherenkov effect has aroused great interest, because it provides an option for developing desktop or even on-chip particle accelerators. So far, only sub-relativistic cases have been investigated. Previous studies showed that when the particle velocity reaches ultra-relativistic range, the acceleration gradient of an inverse Cherenkov laser-driven dielectric accelerator with a single-side dielectric structure drops sharply. Here we illustrate that, by using a double-sided dielectric structure, a high acceleration gradient for ultra-relativistic particles can still be obtained. In addition, we find that, in the ultra-relativistic region, the acceleration gradient increases (not decreases) with the increase of particle energy. The single-sided and double-sided accelerator models under unilateral and bilateral laser-driven conditions are investigated in detail. The results obtained are important for developing an inverse Cherenkov laser-driven dielectric accelerator for both sub-relativistic and ultra-relativistic regions.
Electrical contact effects of flexible self-supporting DNA thin films for storage devices
Authors: Kokkiligadda Samanth , Kesama Mallikarjuna Reddy , Jeon Sohee , Jeong Jun-Ho , Park Sung Ha 
Published: December 2022

Abstract
The development of flexible DNA thin films embedded with diverse functional nanomaterials might be beneficial for electronic devices and biosensors. In this work, we fabricated two different types of electrodes (i.e. metal paste spotted electrodes and metal layer electrodes) on flexible drug- and dye-embedded DNA thin films to examine their electrical and capacitance properties for conduction and energy storage, respectively. Enhanced current and reduced capacitance of drug-embedded DNA thin films compared with pristine DNA with Ag paste electrodes were observed due to the intrinsic characteristics of the drugs. We used the electron-beam deposition process to fabricate relatively large-area metal-coated (e.g. Au and Al) electrodes, which ensures the creation of metal layers on both sides of the flexible thin films while improving metal contact. There was a significant current increase in DNA thin films with metal layer electrodes compared with DNA thin films with Ag paste electrodes. Furthermore, capacitances measured from Au/DNA/Au and Al/DNA/Al capacitors were relatively more stable than from Ag paste DNA thin films. The physical properties of our samples might be easily controlled by manipulating functional nanomaterials in DNA thin films and various types of metal layer electrodes. Our self-supporting DNA thin films with integrated nanomaterials and durable metal layer electrodes might be employed in flexible electronic devices such as nanogenerators, skin electronics and biosensors in the future.
Tunneling magnetoresistance and spin-valley polarization of aperiodic magnetic silicene superlattices
Authors: Villasana-Mercado P , Rojas-Briseño J G , Molina-Valdovinos S , Rodríguez-Vargas I 
Published: December 2022

Abstract
Magnetic silicene superlattices (MSSLs) are versatile structures with spin-valley polarization and tunneling magnetoresistance (TMR) capabilities. However, the oscillating transport properties related to the superlattice periodicity impede stable spin-valley polarization states reachable by reversing the magnetization direction. Here, we show that aperiodicity can be used to improve the spin-valley polarization and TMR by reducing the characteristic conductance oscillations of periodic MSSLs (P-MSSLs). Using the Landauer–Büttiker formalism and the transfer matrix method, we investigate the spin-valley polarization and the TMR of Fibonacci (F-) and Thue–Morse (TM-) MSSLs as typical aperiodic superlattices. Our findings indicate that aperiodic superlattices with higher disorder provide better spin-valley polarization and TMR values. In particular, TM-MSSLs reduce considerably the conductance oscillations giving rise to two well-defined spin-valley polarization states and a better TMR than F- and P-MSSLs. F-MSSLs also improve the spin-valley polarization and TMR, however they depend strongly on the parity of the superlattice generation.
Finite-time blow-up and boundedness in a 2D Keller–Segel system with rotation
Authors: Li Yuxiang , Wang Wanwan 
Published: December 2022

Abstract
This paper deals with the initial-boundary value problem for a Keller–Segel system with rotation

{

u
t

=
Δ
u
−
∇
⋅
(
u

S

θ

∇
v
)
,

x
∈
Ω
,

t
>
0
,

0
=
Δ
v
−
v
+
u
,

x
∈
Ω
,

t
>
0
,

with zero-flux boundary condition for u and zero-Neumann boundary condition for v, where Ω is a bounded domain in

R

2

with smooth boundary

∂
Ω

,

S
θ

=

[

cos
θ

−
sin
θ

sin
θ

cos
θ

]

,

is a rotation matrix with

θ
∈
(
−

π
2

,

π
2

)

. We show that:
Let

Ω
⊂

R

2

be a general smooth bounded domain.
If

m
>

8
π

cos
θ

, then there exists nonnegative initial data u
0 satisfying

∫

Ω

u
0

d

x
=
m

, such that the corresponding nonradial solution of system (*) blows up in finite time and the blow-up point lies in Ω.
If

m
>

4
π

cos
θ

and

∂
Ω

contains a line segment, then there exists nonnegative initial data u
0 satisfying

∫

Ω

u
0

d

x
=
m

, such that the corresponding nonradial solution of system (*) blows up in finite time and the blow-up point lies on the line segment of

∂
Ω

.
Let

Ω
=

B
R

(
0
)

be a disc in

R

2

with radius R > 0 centered at origin. Although there is a rotation effect in system (*), solutions still preserve radial symmetry of initial data. If nonnegative radially symmetric initial data u
0 satisfies

∫

Ω

u
0

d

x
<

8
π

cos
θ

, then the corresponding radial solution of system (*) exists globally in time and is globally bounded.
Current–voltage characteristics and mechanisms of electron emission from cold cathodes in a helium discharge
Authors: Bokhan P A , Gugin P P , Lavrukhin M A , Kim V A , Shevchenko G V , Zakrevsky D E 
Published: December 2022

Abstract
The abnormal discharge (AD) in pure helium and in helium containing molecular impurities was investigated. The obtained results were compared with the parameters of wide-aperture AD and different variants of ‘open’ discharge. It was shown that in all of the investigated types of discharges the current–voltage characteristics (CVCs) and, correspondingly, the emission properties of cold cathodes are determined mainly not by their material, but by the doping of cathodes with atoms of working gases and the purity of experimental conditions. With the impurity content less than 10−4% of the helium atom concentration, the CVCs begin to acquire S-shaped form, which is associated with a change in the electron emission mechanism. It was shown that the diversity of the CVCs is caused by uncertainty in the values of the secondary electron emission coefficients γ and the electron multiplication coefficient α in the cathode layer at reduced electric field strength E/N

>

103 Td. The reproducibility of CVCs and, correspondingly, emission properties of cathodes can be ensured by high purity of the working gas and by maintenance of the cathode doping only by the working gas atoms.
High-speed videomicroscopy of sheared carbonyl iron suspensions
Authors: Martínez-Cano Óscar , Morillas Jose R , Cvek Martin , Ramírez Javier , de Vicente Juan 
Published: December 2022

Abstract
The postyield rheological regime is investigated in sheared magnetic field-responsive composites (i.e. carbonyl iron based magnetorheological fluids). When subjected to uniaxial DC fields, high-speed videomicroscopy techniques and dedicated image analysis tools demonstrate that dispersed magnetic microparticles self-assemble to form concentric layered patterns above a particular shear rate (

γ
˙

R

,c

). This critical shear rate for layer formation is dictated by a critical Mason number

M

n

c

∼

1 that is associated to the destruction of the last doublet in the chain-like aggregates. The number of layers, mean width, percentage of occupation and mean period are found to be very weakly dependent on the shear rate in start-up shearing flow tests. Experimental data for the mean period are in good agreement with an energy minimization theory.
Transient liquid assisted growth of superconducting YBa2Cu3O7−x
films based on pulsed laser deposition
Authors: Queraltó Albert , Sieger Max , Gupta Kapil , Meledin Alexander , Barusco Pedro , Saltarelli Lavinia , de Palau Mariona , Granados Xavier , Obradors Xavier , Puig Teresa 
Published: December 2022

Abstract
We investigated the integration of transient liquid-assisted growth (TLAG) approach for epitaxial YBa2Cu3O7−x
(YBCO) films by physical deposition methodologies (pulsed laser deposition (PLD)), as an additional opportunity for high-throughput growth of YBCO. As a prerequisite, highly flat and amorphous YBCO precursor films were deposited by PLD at temperatures below 400 °C on single-crystalline SrTiO3 (STO) and LaMnO3 (LMO)/STO, as well as industrial coated conductor architectures. Contrary to TLAG based on chemical solution deposition, where BaCO3 elimination is a key factor for the YBCO growth, TLAG-PLD growth is controlled by the transformation of Ba–Cu–O (s) to a transient liquid. High-quality c-axis YBCO films were successfully grown on different substrates, as demonstrated by high-resolution x-ray diffraction and transmission electron microscopy. In-situ resistance measurements revealed that the growth rates around 1000 nm s−1 can be achieved, outperforming the capabilities of standard PLD growth of REBa2Cu3O7 films by few orders of magnitude. Experimental conditions such as temperature, oxygen partial pressure, and heating ramp, were optimized to obtain critical temperature (T
c) values up to 90 K. Critical current densities of 15 MA cm−2 at 5 K and 1.7 MA cm−2 at 77 K were obtained for YBCO films of 450 nm on LMO/STO.
Effect of texture on hydrodynamic journal bearing performance under starvation lubrication
Authors: Li He , Niu Junkai 
Published: December 2022

Abstract
The effect of texture on tribological properties of journal bearings operating under starvation lubrication conditions is studied in this paper. The P-θ model with mass conservation boundary conditions is used to accurately predict the oil film distribution in the full oil film/starvation region of the textured bearing. The effects of various degrees of starvation lubrication on the tribological performance parameters, such as eccentricity, attitude angle, full film area, and friction coefficient, are discussed in textured bearings. The results show that the effect of texture on the bearing performance is affected by starvation lubrication conditions: (1) The effect severity varied with starvation levels; (2) The texturing still improved the operating performance of the journal bearing in the case of weak starvation; (3) Texturing increased the bearing load carrying capacity and reduced the friction coefficient, improving safety and preventing safety accidents due to oil supply problems.
Independent and Joint Associations of Exercise Blood Pressure and Cardiorespiratory Fitness With the Risk of Cardiovascular Mortality
Authors: Jae Sae Young , Kim Hyun Jeong , Kurl Sudhir , Kunutsor Setor K , Laukkanen Jari A 
Published: December 2022

AbstractBackgroundWe tested the hypothesis that an exaggerated systolic blood pressure (ESBP) at maximal exercise workload would be associated with an increased risk of cardiovascular disease (CVD) mortality, and that high cardiorespiratory fitness (CRF) attenuates this risk.MethodsThis prospective study was based on the general population sample of 1,481 men (aged 42–61 years) who did not have a history of CVD at baseline and were followed up in the Kuopio Ischemic Heart Disease cohort study. Exercise blood pressure and CRF were measured during cardiopulmonary exercise testing, and an ESBP was defined by a peak systolic blood pressure ≥210 mm Hg and CRF categorized as tertiles and unfit and fit groups.ResultsDuring a 26-year median follow-up, 231 CVD deaths occurred. After adjusting for potential confounding factors, an ESBP was associated with an increased risk of CVD mortality (hazard ratio [HR] 1.43, 95% confidence interval: 1.06–1.94), while the highest tertile of CRF was associated with a lower risk of CVD mortality (HR 0.64, 0.43–0.95). In the joint association analyses of ESBP and CRF, ≥210 mm Hg-unfit group had a higher risk of CVD mortality (HR 1.70, 1.02–2.83), but also ≥210 mm Hg-fit group had an increased risk of CVD death (HR 1.95, 1.20–3.18) compared with their &lt;210 mm Hg-fit counterparts.ConclusionsThese results indicate that an ESBP is independently associated with an increased risk of CVD death, but moderate-to-high levels of CRF does not attenuate CVD mortality risk in those with ESBP.