bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact on outcomes of measuring lactates prior to ICU in unselected heterogeneous critically ill patients: A propensity score analysis
Authors: Tamakawa Taro , Endoh Hiroshi , Kamimura Natuo , Deuchi Kazuki , Nishiyama Kei 
Published: November 2022

Background
Elevated blood lactate levels were reported as effective predictors of clinical outcome and mortality in ICU. However, there have been no studies simply comparing the timing of measuring lactates before vs. after ICU admission.

Methods
A total of 19,226 patients with transfer time ≤ 24 hr were extracted from the Medical Information Mart for Intensive Care IV database (MIMIC-IV). After 1:1 propensity score matching, the patients were divided into two groups: measuring lactates within 3 hr before (BICU group, n = 4,755) and measuring lactate within 3 hr after ICU admission(AICU group, n = 4,755). The primary and secondary outcomes were hospital mortality, hospital 28-day mortality, ICU mortality, ICU length of stay (LOS), hospital LOS, and restricted mean survival time (RMST).

Results
Hospital, hospital 28-day, and ICU mortality were significantly higher in AICU group (7.0% vs.9.8%, 6.7% vs. 9.4%, and 4.6% vs.6.7%, respectively, p<0.001 for all) Hospital LOS and ICU LOS were significantly longer in AICU group (8.4 days vs. 9.0 days and 3.0 days vs. 3.5 days, respectively, p<0.001 for both). After adjustment for predefined covariates, a significant association between the timing of measuring lactate and hospital mortality was observed in inverse probability treatment weight (IPTW) multivariate regression, doubly robust multivariate regression, and multivariate regression models (OR, 0.96 [95%CI, 0.95-0.97], OR 0.52 [95%CI, 0.46-0.60], OR 0.66 [95%CI, 0.56-0.78], respectively, p<0.001 for all), indicating the timing as a significant risk-adjusted factor for lower hospital mortality. The difference (BICU-AICU) of RMST at 28- days after ICU admission was 0.531 days (95%CI, 0.002-1.059, p<0.05). Placement of A-line and PA-catheter, administration of intravenous antibiotics, and bolus fluid infusion during the first 24-hr in ICU were significantly more frequent and faster in the BICU vs AICU group (67.6% vs. 51.3% and 126min vs.197min for A-line, 19.6% vs.13.2% and 182min vs. 274min for PA-catheter, 77.5% vs.67.6% and 109min vs.168min for antibiotics, and 57.6% vs.51.6% and 224min vs.278min for bolus fluid infusion, respectively, p<0.001 for all). Additionally, a significant indirect effect was observed in frequency (0.19879 [95% CI, 0.14061-0.25697] p<0.001) and time (0.07714 [95% CI, 0.22600-0.13168], p<0.01) of A-line replacement, frequency of placement of PA-catheter (0.05614 [95% CI, 0.04088-0.07140], p<0.001) and frequency of bolus fluid infusion (0.02193 [95%CI, 0.00303-0.04083], p<0.05).

Conclusions
Measuring lactates within 3 hr prior to ICU might be associated with lower hospital mortality in unselected heterogeneous critically ill patients with transfer time to ICU ≤ 24hr, presumably due to more frequent and faster therapeutic interventions.
The Austrian Osteopathic Practitioners Estimates and RAtes (OPERA): A cross-sectional survey
Authors: van Dun Patrick L. S. , Arcuri Lorenzo , Verbeeck Johan , Esteves Jorge E. , Cerritelli Francesco 
Published: November 2022

Introduction
Since the previous survey of the osteopathic profession in Austria was almost a decade ago, an update was necessary. The Osteopathic Practitioners Estimates and RAtes (OPERA) project was developed as a Europe-based survey, whereby an updated profile of the profession not only provides new data for Austria, but also allows for a clear comparison with other European countries.

Methods
A voluntary, online-based, closed-ended survey was distributed across Austria in the period between April and August 2020. The original English OPERA-questionnaire, composed of 52 questions in seven sections, was formally translated in German and adapted to the Austrian situation. Recruitment was performed through social-media and an e-based campaign.

Results
The survey was completed by 338 individuals, of which 239 (71%) were female, and the median age was 40–49 years. Almost all respondents had preliminary healthcare training, mainly in physiotherapy (72%). The majority of respondents were self-employed (88%) and working as sole practitioners (54%). The median number of consultations per week was 21–25 and the majority of respondents scheduled 46–60 minutes for each consultation (69%). The most commonly used diagnostic techniques were: palpation of position/structure, palpation of tenderness and visual inspection. The most commonly used treatment techniques were cranial, visceral and articulatory/mobilisation techniques. The majority of patients estimated by respondents consulted an osteopath for musculoskeletal complaints mainly localised in the lumbar and cervical region. Although the majority of respondents experience a strong osteopathic identity, only a small proportion (17%) advertise themselves exclusively as osteopaths.

Conclusions
This study represents the first published document to determine the characteristics of the osteopathic practitioners in Austria using large, national data. It provides new information on where, how, and by whom osteopathic care is delivered. The information provided may contribute to the evidence used by stakeholders and policy makers for the future regulation of the profession in Austria.
As Sweet as Their Original Utterance: The Reception of the Bible in Aggadic Midrashim
Authors: Kadari Tamar 
Published: November 2022

Abstract
This article analyzes the reception of the Bible in a group of midrashim called amoraic midrash, or aggadic midrash, which reveal the centrality of Scripture in the world of the rabbis. Each midrash is organized around a particular biblical book and its verses, bringing a collection of interpretations taught by different rabbis in the land of Israel in the first five centuries of the Common Era. These compositions were redacted towards the end of the Amoraic Period and immediately after and are therefore referred to as midrashei amoraim. The title midrashei aggadah reflects their content, with almost no interpretations dealing with halakhic issues. In this article, I explain the unique fashion in which midrashei aggadah function as a mode of biblical interpretation, the creative ways biblical verses were employed by the rabbis, and the conception of the Bible’s unity evidenced in their midrashim. I then present the main role of biblical verses as an organizing principle in two genres of midrashic compositions. I conclude with the question of the link between midrashei amoraim and the world of the synagogue. Do these midrashim teach us about biblical reception and interpretation solely among the intellectual elite or also among the general public?
Functional assessment of atrial wall excursion and foramen ovale flap tracings in 3rd trimester as predictor of short-term hemodynamic stability in congenital heart defects fetuses
Authors: Sylwestrzak Oskar , Strzelecka Iwona , Silverman Norman H. , Respondek-Liberska Maria 
Published: November 2022

Abstract

Objectives
Right atrium and left atrium of the fetal heart play a fundamental role in fetal heart circulatory physiology.

Methods
Excursion of fetal atria walls and tracings of foramen ovale (FO) flap movement were analyzed by M-mode echocardiography by new FO index to determine fetal and neonatal outcome in the first week and month of life in various congenital heart defects. The study group was divided into 3 subgroups: group A: neonates stable after birth (all on I.V. prostaglandin infusion) for at least 7 days, group B: neonates unstable after birth (despite I.V. prostaglandin infusion) requiring catheterization procedure or early cardiac surgery <6th day of life and group C: fetuses with in utero demise.

Results
The average values of FO index: group A – 32, group B – 20, group C – 12.Schaffe test showed statistical difference of FO index between group A and B (p=0.029) and group A and C (p=0.001), but no difference between group B and C (p=0.24) The FO index of stability was determined by ROC curve analysis. Cut-off point distinguishing between postnatal stability and postnatal instability + in utero demise constituted FO index=25 (specificity 82%; sensitivity 90%).

Conclusions
Prenatal features of atrial M-mode echocardiography shortly before birth might be helpful to predict the short term prognosis of fetal hemodynamic stability or instability shortly after birth regardless of the type of congenital heart defects (CHD).
NiTi-SiC composite coating on Ti6Al4V alloy produced by SHS using induction heating
Authors: Imak Anil 
Published: November 2022

Abstract
In this study, NiTi and NiTi-XSiC (1 wt%, 2 wt%, and 4 wt%) powders were coated on the Ti6Al4V surface by the self-propagating high-temperature synthesis (SHS) method using induction heating. Optic microscope and a scanning electron microscope (SEM) for the microstructural properties of coatings, energy dispersive spectrometry (EDS) for element distribution analysis, and X-ray diffractogram (XRD) for phase component analysis were carried out. The microhardness difference between the coating and the substrate was assessed by using the Vickers hardness scale. The microhardness increased with the addition of SiC, and the highest hardness value was 1416 Hv and detected in the sample NiTi–SiC 4 wt%. Phases formed by diffusion during solidification in the compounds Ti, Al, NiTi, NiTi2, NiAl, Ni3Al, Al3Ti, and TiO2, respectively.
Effects of silver interlayer thickness on the microstructure and properties of electron beam welded joints of TC4 titanium and 4J29 Kovar alloys
Authors: Mo Defeng , Yu Liquan , Shi Xinmin , Zhao Tong , Li Xue , Zeng Zhijiang , Gong Haimei 
Published: November 2022

Abstract
Electron beam welding of TC4 titanium alloy and 4J29 Kovar alloy was performed by using different thicknesses of silver interlayers. The microstructure and the composition of welded joints were characterized by scanning electron microscopy, X-ray diffraction, and energy-dipersive spectrometry. The mechanical properties of welded joints were evaluated by tensile strength tests. The results indicated that Ag thickness has great effects on the weld appearance, microstructure, and mechanical properties of electron beam-welded joints. In case of 0.3 and 0.4 mm thickness of Ag interlayers, a considerable part of 4J29 and TC4 melts and a large amount of Fe, Ti, and Ni elements diffuse into the molten pool forming intermetallic compounds (IMCs) such as TiFe2, NiTi, and FeTi. In case of 0.6 mm thickness of Ag interlayer, the welded joint exhibits brazing characteristics with little IMCs near the fusion line of 4J29 Kovar alloy side. When the thickness of the Ag interlayer increases to 0.8 mm, the diffusion of Ti and Fe elements is completely inhibited by Ag. As the thickness of the Ag interlayer increases from 0.3 to 0.8 mm, the tensile strength of the welded sample shows a phenomenon that first rises and then falls, and the largest tensile strength is 243 MPa.
The Generic Inhibitory Function of Corollary Discharge in Motor Intention: Evidence from the Modulation Effects of Speech Preparation on the Late Components of Auditory Neural Responses
Authors: Zheng Xiaodan , Zhu Hao , Li Siqi , Tian Xing 
Published: November 2022

AbstractThe importance of action–perception loops necessitates efficient computations linking motor and sensory systems. Corollary discharge (CD), a concept in motor-to-sensory transformation, has been proposed to predict the sensory consequences of actions for efficient motor and cognitive control. The predictive computation has been assumed to realize via inhibiting sensory reafference when actions are executed. Continuous control throughout the course of action demands inhibitory function ubiquitously on all potential reafference when sensory consequences are not available before execution. However, the temporal and functional characteristics of CD are unclear. When does CD begin to operate? To what extent does CD inhibit sensory processes? How is the inhibitory function implemented in neural computation? Using a delayed articulation paradigm with three types of auditory probes (speech, nonspeech, and nonhuman sounds) in an electroencephalography experiment with 20 human participants (7 males), we found that preparing to speak without knowing what to say (general preparation) suppressed neural responses to each type of auditory probe, suggesting a generic inhibitory function of CD in motor intention. Moreover, power and phase coherence in low-frequency bands (1–8 Hz) were both suppressed, indicating that inhibition was mediated by dampening response amplitude and adding temporal variance to sensory processes. Furthermore, inhibition was stronger for sounds that humans can produce than nonhuman sounds, hinting that the generic inhibitory function of CD is regulated by the established motor–sensory associations. These results suggest a functional and temporal granularity of corollary discharge that mediates multifaceted computations in motor and cognitive control.
Sounding the Alarm: Sex Differences in Rat Ultrasonic Vocalizations during Pavlovian Fear Conditioning and Extinction
Authors: Laine Mikaela A. , Mitchell Julia R. , Rhyner Johanna , Clark Rose , Kannan Akshara , Keith Jack , Pikus MaryClare , Bergeron Emmett , Ravaglia Isabella , Ulgenturk Ece , Shinde Ashwini , Shansky Rebecca M. 
Published: November 2022

AbstractPavlovian fear conditioning is a prevalent tool in the study of aversive learning, which is a key component of stress-related psychiatric disorders. Adult rats can exhibit various threat-related behaviors, including freezing, motor responses, and ultrasonic vocalizations (USVs). While these responses can all signal aversion, we know little about how they relate to one another. Here we characterize USVs emitted by male and female rats during cued fear acquisition and extinction, and assess the relationship between different threat-related behaviors. We found that males consistently emitted >22 kHz calls (referred to here as “alarm calls”) than females, and that alarm call frequency in males, but not females, related to the intensity of the shock stimulus. Interestingly, 25% of males and 45% of females did not emit any alarm calls at all. Males that did make alarm calls had significantly higher levels of freezing than males who did not, while no differences in freezing were observed between female Alarm callers and Non-alarm callers. Alarm call emission was also affected by the predictability of the shock; when unpaired from a tone cue, both males and females started emitting alarm calls significantly later. During extinction learning and retrieval sessions, males were again more likely than females to emit alarm calls, which followed an extinction-like reduction in frequency. Collectively these data suggest sex dependence in how behavioral readouts relate to innate and conditioned threat responses. Importantly, we suggest that the same behaviors can signal sex-dependent features of aversion.
M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination
Authors: Li Yang , Wu Yufan , Khan Ihsan , Zhou Jianteng , Lu Yue , Ye Jingwei , Liu Junyan , Xie Xuefeng , Hu Congyuan , Jiang Hanwei , Fan Suixing , Zhang Huan , Zhang Yuanwei , Jiang Xiaohua , Xu Bo , Ma Hui , Shi Qinghua 
Published: November 2022

AbstractFollowing meiotic recombination, each pair of homologous chromosomes acquires at least one crossover, which ensures accurate chromosome segregation and allows reciprocal exchange of genetic information. Recombination failure often leads to meiotic arrest, impairing fertility, but the molecular basis of recombination remains elusive. Here, we report a homozygous M1AP splicing mutation (c.1074 + 2T > C) in patients with severe oligozoospermia owing to meiotic metaphase I arrest. The mutation abolishes M1AP foci on the chromosome axes, resulting in decreased recombination intermediates and crossovers in male mouse models. M1AP interacts with the mammalian ZZS (an acronym for yeast proteins Zip2‐Zip4‐Spo16) complex components, SHOC1, TEX11, and SPO16. M1AP localizes to chromosomal axes in a SPO16‐dependent manner and colocalizes with TEX11. Ablation of M1AP does not alter SHOC1 localization but reduces the recruitment of TEX11 to recombination intermediates. M1AP shows cytoplasmic localization in fetal oocytes and is dispensable for fertility and crossover formation in female mice. Our study provides the first evidence that M1AP acts as a copartner of the ZZS complex to promote crossover formation and meiotic progression in males.
Developing an FASD Health Promotion Social Media Campaign Using Community-Based Participatory Peer Review: Notes From Atlantic Canada
Authors: Dunbar Winsor Katharine , Squires Laura , Peters Adrienne 
Published: November 2022

Introduction: Health promotion awareness activities by health agencies, such as those by the Public Health Agency of Canada, aim to increase health literacy, often using social media campaigns to reach large audiences. Objectives: The objective of this research was to explore how community peer-reviewed social media content can facilitate the reach of health promotion campaigns, with specific regard to awareness around fetal alcohol spectrum disorder (FASD), alcohol, and pregnancy in Atlantic Canada. Methods: We developed a health promotion social media campaign consisting of 16 digital posters, then implemented a community-based participatory peer-review process to request input and feedback from individuals with lived experiences, caregivers, professionals who work with individuals with FASD, and various advocates for FASD throughout Atlantic Canada. Reviewer comments were then directly applied to update poster content, which was redistributed for secondary approval before circulation on Facebook and Instagram. Results: Reviewer feedback was constructive, with various suggestions for updates being applied to images and text choices. Once posted, the health promotion campaign was well received and reached over half a million viewers across the two platforms in the first three months. Engagement and interactions were overall positive, with minimal negative responses and only one post flagged by the platform as a social issue advertisement. Discussion/Conclusion: With the inclusion of diverse voices from the FASD community in the co-creation of the content, we argue that the campaign’s style, messaging, and language more accurately reflected the intended audiences and was made accessible to a wider demographic, thus strengthening awareness and prevention messages. We explore a health promotion social media campaign development process, providing valuable examples of how to encourage and create more safe spaces that promote open conversations about health and gradually dismantle outdated ideas and systems so we can begin addressing stigma by delivering accurate, non-judgmental health information.
Identifying and Mapping Canadian Registered Dietitians’ Perceptions and Knowledge of, and Experiences with, Weight-Related Evidence in Nutrition Care: A Scoping Review Protocol
Authors: Waugh Rachel , Mireault Amy , Rothfus Melissa A. , Stoneman Scott , Lee-Baggley Dayna , Lengyel Christina , Norris Deborah , Snelgrove-Clarke Erna , Joy Phillip , Grant Shannan 
Published: November 2022

Objective: The objective of this scoping review is to identify and map the currently available peer-reviewed and grey literature exploring Canadian registered dietitians’ (RDs’) perceptions and knowledge of, and experiences with, weight-related evidence in nutrition care. Introduction: Weight, skin fold calipers, body mass index (BMI), and other means of measuring and describing body size, have been associated with risk, progression, and nutrition intervention success with several disease states. Interpretation and application of weight-related evidence can be impacted by several non-medical factors, including practitioner perspective, evidence interpretation and application, lived experience, and bias. Each of these outcomes may differ between RDs and are not easily described or understood. Inclusion Criteria: Original peer-reviewed studies and grey literature published in English that explore Canadian RDs’ perceptions of, knowledge of, and experiences with weight-related evidence in nutrition care will be included. Methods: Following the JBI scoping review design and associated methodology, including the three-step search strategy process, four databases will be searched: CINAHL (EBSCO), MEDLINE (Ovid), Embase (Elsevier), and Scopus (Elsevier). Grey literature will be searched using Google Scholar, Google, and Microsoft Bing, and a search strategy specific to grey literature has been developed in partnership with the research team’s librarian (MR). Screening and extraction will be led by two independent reviewers (RW, AM), and conflicts will be resolved either by discussion or through a third reviewer (SG). Data will be presented using diagrams and/or tables, including a narrative summary. The Delphi method will be used for community consultation, that will occur throughout this study.
Youth in Elderly Care Sector – Mission Impossible?
Authors: Krutulienė Sandra , Okunevičiūtė Laima , Gruževskis Boguslavas 
Published: November 2022

The aging of population leads to the outcome that number of social care sector clients grows steadily. Hence the research highlighted that average age of the workforce in social care sector is also rising. An important question is how to attract and retain young people in the care sector for the elderly in the context of an aging society with the growing importance of the care economy. The study aims to reveal the factors motivating young people (18-29 years old) to employ and their attitudes towards work in the elderly care sector to. The research investigated the links between prosocial motivation and the attitudes of unemployed young people registered in the Employment Service toward work in the elderly care sector.
The results of the study identified main directions, which could encourage more young people to get involved in the elderly care sector: promoting prosocial motivation of the individuals, increasing the flexibility of social services for the elderly and ensuring good working conditions. The study revealed significant role of the employment service as an intermediary between the young person and the institution providing social services and changing public attitudes towards work in the care sector for the elderly.