bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced results of Fortelyzin® use in the FRIDOM1 study and real clinical practice
Authors: Markov V. A. , Duplyakov D. V. , Konstantinov S. L. , Klein G. V. , Aksentiev S. B. , Platonov D. Yu. , Vyshlov E. V. , Ponomarev Е. A. , Rabinovich R. M. , Makarov E. L. , Kulibaba E. V. , Yunevich D. S. , Kritskaya O. V. , Baranov E. A. , Talibov O. B. , Kutsenko V. A. , Orlovsky A. A. , Vyazova N. L. , Koledinsky A. G. , Semenov A. M. , Semenov M. P. , Yarovaya E. B. , Uskach T. M. , Shakhnovich R. M. , Tereshchenko S. N. , Markin S. S. 
Published: September 2022

Aim.To study the effectiveness of Fortelyzin® in subgroups with different body weights in patients with ST-segment elevation acute myocardial infarction (STEMI) in the FRIDOM1 study and real clinical practice.Material and methods.Fortelyzin® was administered in a single-bolus dose of 15 mg over 10 seconds, regardless of the body weight of patients. Metalyse® was administered in a single-bolus dose of 30-50 mg over 10 seconds, depending on body weight. The one-year results of the FRIDOM1 study were evaluated by the clinical centers using telephone contact. Monitoring of Fortelyzin® use was carried out by inpatient physicians, emergency doctors and paramedics by filling out a monitoring sheet in the period from June 2013 to December 2021 in 19243 patients with STEMI.Results.In the FRIDOM1 study, the distribution of patients depending on body weight in the Fortelyzin® (n=190) and Metalyse® (n=191) drug groups was as follows: up to 60 kg — 4 people each (p=1,00); from 60 to 70 kg — 21 and 23 (p=0,87); from 70 to 80 kg — 39 and 43 (p=0,71), from 80 to 90 kg — 63 and 47 (p=0,07); from 90 to 100 kg — 30 and 41 (p=0,19); over 100 kg — 33 people (p=1,00) in each group. The effectiveness of thrombolysis according to electrocardiographic (ECG) data in the Fortelyzin® and Metalyse® groups was as follows: up to 60 kg — 75% each (p=1,00); from 60 to 70 kg — 76% vs 83% (p=0,72); from 70 to 80 kg — 82% vs 86% (p=0,76); from 80 to 90 kg — 81% vs 77% (p=0,64); from 90 to 100 kg — 80% vs 81% (p=1,00); over 100 kg — 79% vs 76% (p=1,00); in total — 80% vs 80% (p=0,87). The effectiveness of thrombolysis according to coronary angiography (CAG) (TIMI 2-3) in the Fortelyzin® and Metalyse® groups was as follows: up to 60 kg — 100% vs 50% (p=0,43); from 60 to 70 kg — 81% vs 67% (p=0,48); from 70 to 80 kg — 74% vs 84% (p=0,41); from 80 to 90 kg — 70% vs 72% (p=1,00); from 90 to 100 kg — 67% vs 66% (p=1,00); over 100 kg — 58% vs 64% (p=0,80); in total — 70% vs 71% (p=0,76). The one-year survival rate in the FRIDOM1 study in the Fortelyzin® and Metalyse® groups was 94% (p=0,91). The administration of Fortelyzin® in patients with STEMI caused blood flow restoration according to ECG data in 14624 of 19243 patients (76%), while according to CAG (TIMI 2-3) — in 3422 of 4805 patients (71%). Inhospital mortality was 5% (n=962), while intracranial hemorrhage developed in 0,5% (n=92).Conclusion.The use of Fortelyzin® in the FRIDOM1 study and in real clinical practice in a single-bolus (10 sec) dose of 15 mg in patients with STEMI with any body weight showed its high efficacy and safety, including at the prehospital stage.
¿Por qué la investigación es interdisciplinaria? A propósito de los derechos, el conflicto de principios, el comercio y el derecho comparado
Authors: Agudelo Agudelo Carlos Alberto 
Published: September 2022

En primer lugar, quiero agradecer a todos aquellos que colaboran con la Revista Jurídicas, en especial, a Pamela Zamora, la asistente editorial, pero también al equipo editorial, los pares evaluadores, los articulistas, y todos aquellos que de una u otra manera apoyan con el proceso de publicación de la revista. A la Vicerrectoría de Investigaciones de la Universidad de Caldas y su grupo de apoyo, como correctores de estilo y demás. Sin este grupo humano la revista no estaría en el sitio en el que se encuentra local e internacionalmente. A todos ellos, muchas gracias.
Voy a mostrar con las publicaciones de este volumen por qué nuestro interés de investigación es el interdisciplinario en una revista denominada Jurídicas.
La Corte Suprema chilena y la protección de la libertad personal de los migrantes: un estudio jurisprudencial
Authors: Henríquez Viñas Miriam 
Published: September 2022

El trabajo tiene como objetivo identificar los supuestos de afectación de la libertad personal de los migrantes derivados de la aplicación de la ley de extranjería con motivo de las medidas de expulsión y su consecuente control por la Corte Suprema vía habeas corpus; evaluar la consistencia de los argumentos planteados; y verificar la normativa aplicada en la decisión de los casos. La metodología utilizada se basa en un análisis jurisprudencial, quepermite inferir como resultado que, en los últimos cinco años, el máximo tribunal ha razonado progresivamente aplicando las normas constitucionales y ciertos estándares internacionales. De esta manera, la Corte Suprema ha asegurado la protección de la libertad personal de los migrantes ante expulsiones ilegales o arbitrarias. Concluye que, a pesar de la asincronía y eventuales inconsistencias entre el marco legal y las normas convencionales y constitucionales vigentes en materia migratoria, la Corte Suprema de Chile ha acogido los habeas corpus deducidos en favor de los migrantes sujetos a medidas de expulsión.
Burns of oral mucosa – A review
Authors: Jadhav Karishma Dattatray , Verma Jayeeta 
Published: September 2022

The objective of this review is to understand burns of oral mucosae as a type of injury, the different etiologies, clinical features and management of these oral burns in clinical practice. This review aims to aid dentists to evaluate and assess patients sustaining burn injuries in a better way and to understand the varied treatment protocols for particular types of burns in order to help patients restore their oral health.Articles from PubMed and Google Scholar (from1991 to 2019) were reviewed. All articles relevant to the topic, case reports and literature reviews were included in this review. No articles were excluded.All included articles suggested that burns are a type of tissue injury that can produce localized or diffuse areas of tissue damage depending on the severity and extent of the insult. Burns of the oral mucosa may be caused by thermal, mechanical, chemical, electrical or radiation injury. Thermal burns are usually caused due to ingestion of high temperature foods or drinks. Similarly, chemical burns occur due to exposure of oral mucosa to acids or alkalis or certain drugs. Electrical burns are less common, however, they are mostly noted in children due to biting onto electrical cables or wires etc. Clinical features of all types of burns range from whitish red erythema to necrotic patches. The sites of burns usually vary based on their etiology. Although, there are some contemporary guidelines, there exists no specific standard of care with regards to management of different kinds of burns. This article aims to form a general review of burns of the oral mucosa and its treatment guidelines.
Knowledge and fear for dental treatments due to Covid-19
Authors: Raina Sakshi , Raina Romshi , Priya Pallavi , Tewari Nishant Kumar , Kumari Madhuri , Raaj Vaibhava 
Published: September 2022

Covid 19 have created severe worries, fear & anxiety among every individual. Production of aerosols during various dental procedure have definitive potential of transmitting covid 19 to one another. After three phases of COVID pandemic in India, there is lot of changes and challenges in health care services. The dental treatment have became an issue which need to be well addressed. Out of 500 individual only 410 individual gave their consent for the study. Offline questionnaire survey was conducted among adults above 21 years. The questionnaire included their demographic details and question related to their knowledge and fear of undergoing dental treatment during this pandemic situation. Among 410 individual who participated in the study, 21% of the individual had covid symptoms. 35% told that they are afraid of dental treatment during pandemic where as 45% almost half the individual said they will take the treatment if its only emergency. The main reason for this fear was infection that they can get while getting treated or while in a dental clinic or hospital. The fear of dental treatment during pandemic is not that high. This may be due to recent advances in dental procedure and sterilization. The knowledge of maintaining good oral care is been adapted by maximum individual.
Comparative evaluation of smokers palate in beedi vrs smokers in rural area of Vaishali district
Authors: Raina Sakshi , Raaj Vaibhava , Mallik Manisha , Raj Nikhil , Kumari Madhuri 
Published: September 2022

Somkers palate or Nicotine stomatitis is a whitish papuler lesion seen on the hard and soft palate in the oral cavity that is usually seen in individual who are exposed to any type of smoking habit. To evaluate and correlate the smoking habit in individual with different pattern of smoker’s palate depending on their use. A total of 920 subjects were assessed undergoing routine dental checkup in the dental Opd of a polyclinic. The evaluation and correlation between duration and frequency of smoking habit was done. The individual using beedi were high in number than the individual using cigarette. In almost 726 individual smokers palate were present and the grade of smokers palate also increase with the increase or frequency and time of use. In the present study it is found that beedi smoking is more common than cigarette smoking. There is direct relationship of frequency and duration in individual having smokers palate.
Journey to a confident smile: Management of hyperpigmented lips with 940 nm diode laser along with topical vitamin C - A case series
Authors: Singh Anjali , Dubey Shalini , Kaur Bhavneet , Chandra Joohi , Sekhar Vidya , Malhotra Sumit 
Published: September 2022

To evaluate and compare the effects of subgingival application of ozone gel and chlorhexidine gel in combination with traditional mechanical therapy in patients with plaque induced gingivitis undergoing orthodontic therapy. 20 subjects aged 15-40 were randomized by a simple method of alternatively assigning them to the test and control group in 1:1 ratio. In the control group 10 patients undergoing Orthodontics treatment with inflamed gingiva were selected for scaling and 1 ml of 0.2% Chlorhexidine gel was delivered subgingivally. In the test group10 patients undergoing Orthodontic treatment with inflamed gingiva were selected for scaling and 1 ml of Ozone (70 mcg/ml) gel was delivered subgingivally. Both the therapeutic approach showed significant (p&#60;0.05) reduction in plaque index, gingival index and sulcus bleeding index when compared from baseline to 3 months. Both the therapeutic approaches led to significant reduction in microbiological colony count when compared from baseline to 3 months. On intergroup comparison Ozone Group showed higher reduction in GI, PI, SBI as compared to Chlorhexidine group but the difference was statistically non-significant. ozone gel can be an effective and practical alternative to chlorhexidine gel.
The Strategy of Religious Culture in Shaping Student Character at MAN 1 and MAN 2 Tulungagung Indonesia
Authors: Mualim  , Akhyak  , Syafi'i Asrop 
Published: September 2022

This research is motivated by a religious culture that is built and realized to instill values ​​into students. Religious character culture is one method of comprehensive value education. In its embodiment, there is the inculcation of values, setting an example, and preparing the younger generation to be independent by teaching and facilitating responsible moral decisions and other life skills. The question of this research is how the strategy of implementing religious culture shapes students' character in MAN 1 and MAN 2 Tulungagung. This research uses a qualitative multi-site study approach. Data collection techniques used include in-depth interviews, participant observation, study documentation. The data collected were analyzed through the three techniques from a single site and cross-site analysis. At the time of data collection, the data was obtained and tested using the triangulation method and the persistence of observation and validity of the data. The results of this study indicate that the strategy for implementing religious culture in shaping students' character is carried out by a) Applying habituation with the habituation carried out within the individual will be faster to understand and understand religious culture contained in daily actions. b) Providing exemplary; c) Togetherness in religious civilizing activities.
Print-based storybook in the mother tongue for teaching COVID-19 prevention in the Philippines
Authors: Arnilla Arvin Kim 
Published: September 2022

The literature has shown that storybooks are helpful resources to teach young children about significant health, safety, and nutrition issues. The current project sought to produce a storybook about COVID-19 prevention written in the mother tongue (Akeanon) for young children using the Analysis-Design-Development-Implementation-Evaluation (ADDIE) model as a guide. In general, the mother tongue-based storybook is highly accepted by evaluators as they grasped the most significant intent in producing the resource, which is to instil staying at home to break the transmission of the virus and observe hygienic practices, primarily handwashing with soap and water. Additional information on COVID-19 signs and symptoms was also recommended to maximise its effectiveness for health teaching. While health literacy materials in English are welcome in the Philippines, the results of this project confirm that mother tongue-based instructional materials for COVID-19 are highly accepted, especially when validated resources are deemed helpful to raise awareness and encourage appropriate attitude and behaviour towards its prevention.

Keywords: ADDIE Model, COVID-19 prevention, instructional material, mother tongue, storybook
Students’ attitudes towards using English as a medium of instruction in scientific disciplines: Challenges and solutions
Authors: Almudibry Khaled 
Published: September 2022

This study aims at exploring the challenges faced by university EFL students and the solutions which they use to overcome these challenges. Therefore, this study investigated non-English major learners’ attitudes towards the challenges associated with using English as a medium of instruction in scientific disciplines. Qualitative research methods were used involving the use of classroom observations, surveys and interviews to collect the required data. The results showed a positive perception with regard to the use of English as a medium of instruction (EMI) among the participants. In addition, based on the participants’ results, the research highlights four themes as presenting the greatest challenges. Suggestions and recommendations are made for enhancing the successful use of EMI.

Keywords: challenges; English as a medium of instruction; scientific disciplines IS THIS WHAT YOU MEAN?
The effectiveness of learning to improve students higher-order thinking skills
Authors: Shanti Made Rai Suci , Istiyono Edi , Munadi Sudji 
Published: September 2022

Higher order thinking skills (HOTS) are expected to be skills needed now and in the future. Many learning strategies are applied to increase HOTS. Nonetheless, how effective is this in improving students’ HOT abilities? This study will examine how effective learning is to improve HOT skills. We used meta-analysis research techniques to analyse the research quantitatively. We selected 21 out of 60 articles from Google Scholar that used models, media and science learning assessments to improve HOT. Heterogeneity analysis (trim-fill, funnel plot approach and Z-value calculation) was used to prove the absence of publication bias. Forest plot analysis showed an average increase in learning effectiveness (0.32), with a moderate effect. It shows that the effectiveness of learning is supported by strategies of using media, methods and assessment. These factors are proven to increase the effectiveness of students’ HOT abilities.

Keywords: HOTS, learning, meta-analysis.
Digital technologies integration in the classroom. A teacher’s perspective
Authors: Prodani Rafail , Çobani Silvja , Andersons Aigars , Bushati Jozef 
Published: September 2022

This paper focuses on determining and analyzing the factors which lead high school teachers in southeastern Albania to integrate digital technologies in the classroom. For this purpose, a survey was conducted. Factor analysis was used to determine the factors and the Pearson correlation coefficient was used to analyze the correlation of these factors. This method proved to be stable and reliable and can be recommended for use in educational technology research. Based on the factors’ inter-correlations, an apparent result is that: a better knowledge of software applications positively influences teachers’ digital technology use and their self-confidence. It also increases teachers’ motivation to use digital technologies in the classroom. Competence seems to be the most relevant factor that influences teachers to integrate digital technologies in the classroom.

Keywords: digital technologies, competence, factor analysis, teaching, high school;
Development of acmeological competencies of future preschool organisation teachers
Authors: Anarbek Laura , Sarsenbayeva Gulnara , Uteubayeva Elmira , Abuova Nabat , Tolybayeva Zhanar 
Published: September 2022

The research aimed to develop the acmeological competencies of future preschool organisation teachers. The research was applied in the spring term of 2021–2022. The study, which was carried out with the participation of 228 pre-service teachers, was carried out in the survey model. In the study, acmeological education was given to pre-service teachers with 4-week distance education. To collect data in the study, the ‘activating potential and competence’ data collection tool developed by the authors of the study was used. The findings collected from the data collection tool used in the research have been added to the research in the form of tables and comments. When the results obtained are taken into consideration, it is seen that the acmeological status of the pre-service teachers participating in the research was improved and they will use this field in their education.
Keywords: Acmeology, teacher candidates, distance education, potential data;
Formation of research skills of students through solving problems in teaching mathematics in primary classes
Authors: Luiza Rizayeva , Rabiga Kenzhebekova , Amina Amirova , Borashkyzy Akhatayeva Ulsana , Uaidullakyzy Elmira , Bakhytgul Smanova 
Published: September 2022

This study aimed to create students’ research skills by solving problems in teaching mathematics in primary school classes and was designed according to this purpose. In this context, it is aimed to conduct a study on teaching mathematics to primary school students. The research was created and implemented in the 2021–2022 spring academic year. 296 primary school students voluntarily participated in the research. In the research, problem-solving training in mathematics teaching was given to the students participating in the study in the form of a 2-week online education. To collect data in the study, the ‘mathematics and problem-solving’ data collection tool, which was developed by the researchers and whose validity and reliability were obtained, was used. The data collection tool used in the research was delivered and collected by the online method. The analysis of the data was made by using the Statistical Package for the Social Sciences programme, frequency analysis and t-test, and the results were added to the research in the presence of tables. As a result of the research, it is seen that primary school students’ problem-solving situations improved with mathematics teaching and they enjoyed these methods and achieved positive results.
Keywords: Primary school students, teaching mathematics, problem-solving, distance education;
Development of communication skills of older preschool children through information technology
Authors: Saule Yerkebayeva , Sarsengul Jetpisbayeva , Ulbossyn Kyyakbayeva , Dolores Nurgaliyeva , Galiya Abilbakieva , Nazerke Shalkharbekova 
Published: September 2022

The purpose of this research is to get the opinions of preschool teachers to improve the communication skills of preschool children through information technology. The phenomenological design, one of the qualitative research approaches, was used in the research. The participant group of the research consists of 62 preschool teachers who teach in various preschool educational institutions in the city of Nursultan, Kazakhstan. Research data were collected with a semi-structured interview form. As a result of the research, it has been determined that the majority of preschool teachers have a very high tendency to use information technologies. On the other hand, it has been determined that the majority of preschool teachers participating in the research have a medium level of competence in using information technologies. The majority of preschool teachers participating in the research stated that they sometimes use information technologies to develop children's communication skills. Preschool teachers participating in the research offered suggestions for teachers and schools about using information technologies in the development of children's communication skills. The majority of teachers suggested the creation of information technology-supported lesson programmes, the design of group projects and the creation of educational games. As for schools, the majority of teachers suggested creating classrooms with technological equipment in schools.
Keywords: Communication skills of preschool children, information technologies, teacher opinions;
Development of augmented reality-based learning models for students with specific learning disabilities
Authors: Wiliyanto Dian Atnantomi , Gunarhadi Gunarhadi , Anggarani Fadjri Kirana , Yusuf Munawir , Subagya Subagya 
Published: September 2022

This study aims to develop a learning model based on augmented reality applications to overcome barriers to learning mathematics for Students with Specific Learning Disabilities (SLD) in Inclusive Schools. This study uses a 4D model with the development of an AR-based learning model involving ten expert validators, and the respondents employed in the analysis of data collection needs at the specified stage are 40 Special Education Teachers (STC) who teach SLD students in inclusive schools. The results of this study indicate that research on the achievement of the learning process shows that there is still hope and excellence in achieving the learning process desired by STC, where the learning process is still in the sufficient category level and necessary, as a learning medium in the learning process in the inclusive class. The validation test also shows that augmented reality application technology is included in the very good category, including the very good class. This augmented reality-based learning model is valid for use in the learning process in overcoming barriers to learning mathematics for SLD students in inclusive schools.
Keywords: Augmented Reality, inclusive schools, mathematic, learning model, SLD