bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship Between the Shape of the Spine and the Width of Linea Alba in Children Aged 6–9 Years. Case-Control Study
Authors: Zmyślna Anna , Żurawski Arkadiusz , Rosiński Tomasz , Pogorzelska Justyna , Śliwiński Zbigniew , Śliwiński Grzegorz , Kiebzak Wojciech 
Published: May 2022

IntroductionCivilization development coupled with contemporary lifestyle leads to a systematic increase in postural disorders. An analysis of factors that may provoke postural disorders indicates that such a stimulus may be the diastasis of the rectus abdominis muscles. Moreover, abnormal activity of the rectus abdominis muscles may affect balance disorders through reduced spinal stabilization and disturbed body statics. There is an increase in body posture abnormalities between the ages of 6 and 9 related to new school duties.Purpose of the StudyThe purpose of the study was to evaluate the relationship between the shape of the spine and the width of the linea alba in children aged 6–9 years.Material and MethodThe study was designed to evaluate parameters determining the shape of the spine, and the width of the linea alba in healthy children aged 6–9 years. The study participants were divided into two groups based on the width of the linea alba. The study group with the width of the linea alba &gt;10 mm and the control group with the width of the linea alba ≤ 10 mm. The study group were included 37 children and the control group 24 children. The examination of the linea alba width was performed by a radiology specialist using a linear transducer and SAOTE- My Lab Classc-type ultrasound at rest and during contraction of the rectus abdominis muscles. Parameters describing the shape of the spine were measured using the Diers Formetric 4D system: trunk inclination, trunk imbalance, pelvis tilt, pelvic torsion, kyphotic apex, lordotic apex, kyphotic angle, lordotic angle, rotation angle, trunk torsion, lateral deviation. The obtained results were statistically analyzed using a Paired t test for comparison of differences between the results in the study and control groups and Pearson's test to assess the correlation between the width of the linea alba and parameters describing spinal alignment.ResultsIn both groups, the parameters describing the shape of the spine did not differ from the norms accepted as typical for the age norm. The only statistically significant difference between the study and control group concerned the trunk inclination, which was negative in the study group, signifying a shift of the entire spine axis backwards beyond the vertical.ConclusionsThere is a correlation between the shape of spine and the width of the linea alba in terms of selected parameters determining the body posture in the sagittal plane, which concern: the position of the lumbar lordotic apex, trunk inclination and the depth of the lumbar lordotic angle. The width of the linea alba is not explicitly related to abnormalities of pelvic and spinal alignment in the frontal and transverse planes.
Circulating C-X-C Motif Ligand 13 as a Biomarker for Early Predicting Efficacy of Subcutaneous Immunotherapy in Children With Chronic Allergic Rhinitis
Authors: Cheng Shenghao , Wen Sihui , Xie Shaobing , Zhang Caixia , Zhang Hua , Gao Kelei , Fan Ruohao , Xie Zhihai , Jiang Weihong 
Published: May 2022

BackgroundC-X-C motif ligand 13 (CXCL13) and B cell-activating factor (BAFF) are proven to be involved in inflammatory diseases, but their role in allergic rhinitis (AR) remains unclear. The aim of this study was to investigate the role of serum CXCL13 and BAFF in AR and their clinical values as objective biomarkers to predict the efficacy of subcutaneous immunotherapy (SCIT).MethodsWe prospectively recruited 90 children with AR treated with SCIT and collected their serum specimens before SCIT. One-year follow-up was conducted for all patients, and they were categorized into effective and ineffective groups based on efficacy. The serum concentrations of CXCL13 and BAFF were detected and compared between the two groups. A validation cohort of 52 responders and 26 non-responders were further assessed for both cytokines and serum CXCL13 and BAFF levels were assayed by enzyme-linked immunosorbent assay (ELISA).ResultsEighty children completed the follow-up schedule, and 56 children were categorized into the effective group and 24 children into the ineffective group. The serum levels of CXCL13 in the effective group were clearly higher than those in the ineffective group (P &lt; 0.05). Receiver operating characteristic (ROC) curves revealed the potential values of CXCL13 as a biomarker in predicting the response of SCIT. Further, in the validation cohort, ELISA results demonstrated that serum CXCL13 levels were increased in responders than non-responders (P &lt; 0.05). ROC curves showed good accuracy of serum CXCL13 in predicting the efficacy of SCIT.ConclusionOur discovery–validation study demonstrated that circulating CXCL13 might serve as a novel biomarker to predict the outcome of SCIT in childhood AR. The findings indicated that CXCL13 was involved in the pathological mechanisms of AR and made help to the fundamental therapeutic mechanism of SCIT.
Efficacy and Safety of Stem Cell Therapy in Children With Autism Spectrum Disorders: A Systematic Review and Meta-Analysis
Authors: Qu Jiayang , Liu Zicai , Li Lincai , Zou Zhengwei , He Zhengyi , Zhou Lin , Luo Yaolin , Zhang Minhong , Ye Junsong 
Published: May 2022

AimThere is insufficient evidence regarding the efficacy and safety of stem cell therapy for autism spectrum disorders. We performed the first meta-analysis of stem cell therapy for autism spectrum disorders in children to provide evidence for clinical rehabilitation.MethodsThe data source includes PubMed/Medline, Web of Science, EMBASE, Cochrane Library and China Academic Journal, from inception to 24th JULY 2021. After sifting through the literature, the Cochrane tool was applied to assess the risk of bias. Finally, we extracted data from these studies and calculated pooled efficacy and safety.Results5 studies that met the inclusion criteria were included in current analysis. Meta-analysis was performed using rehabilitation therapy as the reference standard. Data showed that the Childhood Autism Rating Scale score of stem cell group was striking lower than the control group (WMD: −5.96; 95%CI [−8.87, −3.06]; p &lt; 0.0001). The Clinical Global Impression score consolidated effect size RR = 1.01, 95%CI [0.87, 1.18], Z = 0.14 (p = 0.89), the effective rate for The Clinical Global Impression was 62% and 60% in the stem cell group and the control group, respectively. The occurrence events of adverse reactions in each group (RR = 1.55; 95%CI = 0.60 to 3.98; p = 0.36), there was no significant difference in the incidence of adverse reactions between the stem cell group and the control group.ConclusionsThe results of this meta-analysis suggested that stem cell therapy for children with autism might be safe and effective. However, the evidence was compromised by the limitations in current study size, lacking standardized injection routes and doses of stem cells, as well as shortages in diagnostic tools and long period follow-up studies. Hence, it calls for more studies to systematically confirm the efficacy and safety of stem cell therapy for children with autism spectrum disorders.
Associations of DNA Base Excision Repair and Antioxidant Enzyme Genetic Risk Scores with Biomarker of Systemic Inflammation
Authors: Mao Ziling , Gray Abigail L. H. , Gross Myron D. , Thyagarajan Bharat , Bostick Roberd M. 
Published: May 2022

Background: Inflammation is implicated in the etiology of various aging-related diseases. Numerous dietary and lifestyle factors contribute to chronic systemic inflammation; genetic variation may too. However, despite biological plausibility, little is known about associations of antioxidant enzyme (AE) and DNA base excision repair (BER) genotypes with human systemic inflammation.Methods: We genotyped 22 single nucleotide polymorphisms (SNPs) in 3 AE genes, and 79 SNPs in 14 BER genes to develop inflammation-specific AE and BER genetic risk scores (GRS) in two pooled cross-sectional studies (n = 333) of 30–74-year-old White adults without inflammatory bowel disease, familial adenomatous polyposis, or a history of cancer or colorectal adenoma. Of the genotypes, based on their associations with a biomarker of systemic inflammation, circulating high sensitivity C-reactive protein (hsCRP) concentrations, we selected 2 SNPs of 2 genes (CAT and MnSoD) for an AE GRS, and 7 SNPs of 5 genes (MUTYH, SMUG1, TDG, UNG, and XRCC1) for a BER GRS. A higher GRS indicates a higher balance of variant alleles directly associated with hsCRP relative to variant alleles inversely associated with hsCRP. We also calculated previously-reported, validated, questionnaire-based dietary (DIS) and lifestyle (LIS) inflammation scores. We used multivariable general linear regression to compare mean hsCRP concentrations across AE and BER GRS categories, individually and jointly with the DIS and LIS.Results: The mean hsCRP concentrations among those in the highest relative to the lowest AE and BER GRS categories were, proportionately, 13.9% (p = 0.30) and 57.4% (p = 0.009) higher. Neither GRS clearly appeared to modify the associations of the DIS or LIS with hsCRP.Conclusion: Our findings suggest that genotypes of DNA BER genes collectively may be associated with systemic inflammation in humans.
Percutaneous Mechanical Thrombectomy for Acute Limb Ischemia With Aorto-iliac Occlusion
Authors: Yang Xinrui , Li Xiangxiang , Yin Minyi , Wang Ruihua , Ye Kaichuang , Lu Xinwu , Li Weimin , Cheng Yong , Qin Jinbao 
Published: May 2022

BackgroundTo evaluate the outcomes of percutaneous mechanical thrombectomy (PMT) with Rotarex catheter in patients with acute lower limb ischemia (ALI) caused by aorto-iliac occlusion.Materials and MethodsData of patients with ALI caused by aorto-iliac occlusion in our institutions from January 2010 and April 2020 were reviewed. The primary end point was limb salvage rate. The secondary end points included technical success rate, survival rate, complications after the operation and during the follow-up.ResultsA total of 85 patients with ALI was diagnosed with aorto-iliac occlusion. Thirty-eight patients were treated by PMT with Rotarex catheter and enrolled in present study. Twenty-four were male (63.2%), and 14 were female (36.8%). The mean age was 66 years (range 28–83). All 38 patients were treated with PMT, with additional catheter directed thrombolysis (2/38, 5.3%), balloon angioplasty (8/38, 21.1%) and stent deployment (7/38, 18.4%). The mean procedure time was 123 ± 31 min. Seven patients (18.4%) underwent continuous renal replacement therapy. Two patients received major amputations (above the knee) and 2 patients died for renal insufficiency and heart failure during the hospital stay. Thirty-day survival rate was 94.7% and limb salvage was 94.4%. The mean follow-up time was 14.0 months (8–22 months). There was no major amputation and target artery occlusion occurred during the follow-up period.ConclusionPMT with Rotarex catheter could be new option for acute aorto-iliac occlusion, leading to safe and effective results.
Prediction of Post-operative Long-Term Outcome of the Motor Function by Multimodal Intraoperative Neuromonitoring With Transcranial Motor-Evoked Potential and Spinal Cord-Evoked Potential After Microsurgical Resection for Spinal Cord Tumors
Authors: Yamada Shinsuke , Kawajiri Satoshi , Arishma Hidetaka , Isozaki Makoto , Yamauchi Takahiro , Akazawa Ayumi , Kidoguchi Masamune , Kodera Toshiaki , Shibaike Yoshinori , Umeda Hideto , Tsukinowa Yu , Hagihara Ryota , Kikuta Kenichiro 
Published: May 2022

ObjectiveTo examine the effect of multimodal intraoperative neuromonitoring on the long-term outcome of motor function after microsurgical resection for spinal cord tumors.Materials and MethodsConsecutive fourteen patients with spinal tumors who were surgically treated at the University of Fukui Hospital between 2009 and 2020 [M:F = 10:4, ages ranging from 22 to 83 years (mean ± SD = 58 ± 21 years)] were included in this study. There were eight intra-axial tumors and six extra-axial tumors. There were four patients with hypertension, two patients with diabetes mellitus, and four patients with hyperlipidemia. Three patients were under antithrombotic medication, two were under steroid medication, four were current smokers, and four were current drinkers. Manual muscle test (MMT) of the upper and lower extremities of the patients was examined before surgery, 2 weeks after surgery, and at the final follow-up. The mean follow-up period was 38 ± 37 months. McCormick scores were examined before surgery and at the final follow-up. Microsurgical resection of the tumor was underwent through the posterior approach under transcranial motor-evoked potential (TcMEP) monitoring. The MEP of 46 extremities was recorded during the surgery. Gross total resection was achieved in 13 of 14 surgeries. Spinal cord-evoked potential (Sp-SCEP) monitoring was performed in eight of 14 patients.ResultsThe length of peritumoral edema was significantly longer in patients with deterioration of McCormick scores than in patients with preservation of McCormick scores (p = 0.0274). Sp-SCEP could not predict the deterioration. The ratio of MEP at the beginning of the surgery to that at the end of the surgery was the only significant negative factor that predicts deterioration of motor function of the extremity at the final follow-up (p = 0.0374, odds ratio [OR] 1.02E-05, 95% CI 9.13E+01–7.15E+18). A receiver operating characteristic (ROC) analysis revealed that the cutoff value of the ratio of MEP to predict the deterioration at the final follow-up was 0.23 (specificity 100%, specificity 88%, positive predictive value 100%, and negative predictive value 88%) to predict deterioration at the final follow-up.ConclusionsRatio MEP was the most significant negative factor to predict the deterioration of motor weakness at spinal tumor surgery. The setting of the cutoff value should be more strict as compared to the brain surgery and might be different depending on the institutions.
Cardiovascular and Gas Exchange Effects of Individualized Positive End-Expiratory Pressures in Cats Anesthetized With Isoflurane
Authors: Machado Marcela L. , Soares Joao H. N. , Pypendop Bruno H. , Aguiar Antonio J. A. , Braun Christina , Motta-Ribeiro Gabriel C. , Jandre Frederico C. 
Published: May 2022

ObjectivesTo compare the effects of four levels of end-expiratory pressure [zero (ZEEP) and three levels of positive end-expiratory pressure (PEEP)] on the cardiovascular system and gas exchange of cats anesthetized with isoflurane and mechanically ventilated for 3 h with a tidal volume of 10 ml/kg.Study DesignProspective, randomized, controlled trial.AnimalsSix healthy male neutered purpose-bred cats.MethodsAnesthesia was induced with isoflurane and maintained at 1.3 minimum alveolar concentration. PEEP of maximal respiratory compliance (PEEPmaxCrs) was identified in a decremental PEEP titration, and cats were randomly ventilated for 3 h with one of the following end-expiratory pressures: ZEEP, PEEPmaxCrsminus 2 cmH2O (PEEPmaxCrs−2), PEEPmaxCrs, and PEEPmaxCrsplus 2 cmH2O (PEEPmaxCrs+2). Cardiovascular and gas exchange variables were recorded at 5, 30, 60, 120, and 180 min (T5 to T180, respectively) of ventilation and compared between and within ventilation treatments with mixed-model ANOVA followed by Dunnet's and Tukey's tests (normal distribution) or Friedman test followed by the Dunn's test (non-normal distribution). Significance to reject the null hypothesis was consideredp&lt; 0.05.ResultsMean arterial pressure (MAP—mmHg) was lower in PEEPmaxCrs+2[63 (49–69); median (range)] when compared to ZEEP [71 (67–113)] at T5 and stroke index (ml/beat/kg) was lower in PEEPmaxCrs+2(0.70 ± 0.20; mean ± SD) than in ZEEP (0.90 ± 0.20) at T60. Cardiac index, oxygen delivery index (DO2I), systemic vascular resistance index, and shunt fraction were not significantly different between treatments. The ratio between arterial partial pressure and inspired concentration of oxygen (PaO2/FIO2) was lower in ZEEP than in the PEEP treatments at various time points. At T180, DO2I was higher when compared to T5 in PEEPmaxCrs. Dopamine was required to maintain MAP higher than 60 mmHg in one cat during PEEPmaxCrsand in three cats during PEEPmaxCrs+2.ConclusionIn cats anesthetized with isoflurane and mechanically ventilated for 3 h, all levels of PEEP mildly improved gas exchange with no significant difference in DO2I when compared to ZEEP. The PEEP levels higher than PEEPmaxCrs−2caused more cardiovascular depression, and dopamine was an effective treatment. A temporal increase in DO2I was observed in the cats ventilated with PEEPmaxCrs. The effects of these levels of PEEP on respiratory mechanics, ventilation-induced lung injury, as well as in obese and critically ill cats deserve future investigation for a better understanding of the clinical use of PEEP in this species.
Pengaruh Supervisi Akademik Pengawas, Kepemimpinan Kepala Sekolah dan Disiplin Kerja terhadap Kinerja Guru
Authors: Jarir Ibnu , Haryati Sri , Fatmasari Rhini 
Published: May 2022

The objective of this study was to examine the influence of supervisor's academic supervision, principal's leadership and work discipline on teacher performance at the Bulu District Elementary School. This study uses quantitative research methods. The population of this study were 293 teachers from 25 schools. The number of samples taken in the study were 158 teachers. The research instrument used was a questionnaire. The data analysis method used is single regression and multiple regression. Based on the results of the analysis, it can be seen that (1) academic supervision of supervisors has a positive and significant effect on the performance of Bulu District Elementary School teachers (2) Principal leadership has a positive and significant effect on the performance of Bulu Subdistrict Elementary School teachers (3) Work discipline has a positive and significant effect on performance of district elementary school teachers (4) Academic supervision of supervisors, Principal leadership and work discipline have a simultaneous effect on the performance of teachers in Bulu District Elementary School.
Implementasi Kebijakan Penyusunan Laporan Penyelenggaraan Pemerintah Daerah Tahun 2020 di Pemerintah Kota Pangkalpinang
Authors: Mutiahsari Irma , Azhar Azhar , Thamrin M. Husni 
Published: May 2022

The objective of this research is to find out how the implementation of the Minister of Home Affairs Regulation Number 18 of 2020 concerning the Implementation Regulation of Government Regulation Number 13 of 2019 concerning Reports and Evaluation of the Implementation of Local Government carried out by Pangkalpinang City Government in 2020, the supporting and hindering factors in the implementation. The research focused on preparing reports based on government policies using the implementation theory of George Edwards III. Data collecting through document analysis, interviews, and observations using a qualitative approach. Based on the findings in the field, the implementation of Policy for Preparing Regional Government Implementation Reports for 2020 in Pangkalpinang City Government has not gone well. Inhibiting factors include a not yet optimal communication between the central government and local governments in delivering policy information, inadequate quantity of human resources to prepare various kinds of reports, uneven supporting facilities for the preparation of LPPD in each regional agency , a not yet optimal commitment of several regional agencies to meeting data and documents needed to improve the quality of Key Performance Indicators (IKK), the lack of coordination among regional agencies in data fulfillment, and the unavailability of a Standard Operational Procedure (SOP). Supporting factors include good communication between the Secretariat Team and drafting officers, the quality of human resources in terms of education, high commitment of the Secretariat Team, which is chaired by the Regional Secretary, and drafting officers.
Pengukuran Kinerja Bursa Kerja Khusus Sekolah Menengah Kejuruan dalam Meningkatkan Keterserapan Lulusan di Dunia Kerja
Authors: Fitriana Nur , Wibawani Sri 
Published: May 2022

This article aims to describe and analyze the level of achievement of the performance of the Bursa Kerja Khusus (BKK) of Vocational High School in Sidoarjo Regency to improving the absorption of graduates in the working field. The problem focused on BKK's performance has not been effective in carrying out its duties as a work placement service organization and career guidance to students and vocational school graduates in the same manner as the absorption of graduates in the working field, namely The World Business and Industry is still below 75% and vocational school graduates as the highest contributor of open unemployment in Sidoarjo Regency in August 2018-August 2020. To approach the problem used performance assessment theory from Dwiyanto (2018) there are; productivity, service quality, responsiveness, responsibility, and accountability. This research uses descriptive quantitative research methods. The results showed that the performance of BKK SMK Sidoarjo Regency obtained a percentage of 42.5% and the results of each sub-variable performance; (1) productivity dimension obtained 42.5% (2) dimension of service quality obtained 55% (3) dimension of responsiveness obtained 42.5%, (4) dimension responsibilities obtained 50%, and (5) dimension accountability obtained 37.5%.
Pengembangan Bahan Ajar Perencanaan Pembelajaran Ilmu Pengetahuan Sosial Berbasis Scientific Approach
Authors: Wardani Wardani 
Published: May 2022

This study aims to to produce the teaching material planning learning social studies based scientific approach and engetahui student assessment against teaching book learning scientifiec approach planning based social studies. The development of the teaching material learning social studies approach planning based scientific research methods have research and development (R & D). The use of a method of R & D so that yield the product in the form of the teaching material planning learning social studies based scientific approach. A method of R & D that will be used referring to ten steps the theory Borg and Gall. The results of research and discussion on, that teaching materials scientifiec approach planning based on social class obtains a judgment very reasonable from the review the matter, media experts review, and a review of a linguist. In addition, the teaching materials scientifiec approach planning based on social class was tested a small group has given assessments of 9 students were attending a course planning learning social class in the study tadris social class obtains a judgment very reasonable for use. So based on this research writer can conclude that the development planning teaching materials based on social class scientifiec approach should be used.
Hubungan Keseimbangan Kehidupan Kerja dan Keterkaitan Pegawai dengan Kepuasan Kerja
Authors: Aritonang Marsela Giovani , Lubis M Rajab , Ideyani Nadra 
Published: May 2022

The aimed of this research is to determine the relationship between work life balance and employee engagement with job satisfaction among the employees of PT Bank Central Asia Medan. The problem is focused on the work life balance and employee engagement by the company. Measuring tool use is work life balance scale, employee engagement scale, and job satisfaction scale to 92 employees of PT Bank Central Asia Medan and conducting quantitative data analysis with correlated method. The results obtained that there is a significant positive relationship between work life balance and employee engagement with job satisfaction. With the value of F = 4.16 and the value p = 0.000. Work life balance contributes to job satisfaction of 22%. Employee engagement contributes to job satisfaction of 16.7%. work life balance and employee engagement to job satisfaction as much as 38,7% this means there are still 61,3% other factors that can affect Job satisfaction.