bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Nomogram for Predicting Long-Term Overall Survival of Esophageal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy Plus Surgery: A Population-Based Study
Authors: Chen Mingduan , Hong Zhinuan , Shen Zhimin , Gao Lei , Kang Mingqiang 
Published: May 2022

ObjectiveNeoadjuvant chemoradiotherapy (nCRT) plays an important role in patients with locally advanced esophageal cancer (EC). We aim to determine the prognostic risk factors and establish a reliable nomogram to predict overall survival (OS) based on SEER population.MethodsPatients with EC coded by 04–15 in the SEER database were included. The data were divided into training group and verification group (7:3). The Cox proportional-risk model was evaluated by using the working characteristic curve (receiver operating characteristic curve, ROC) and the area under the curve (AUC), and a nomogram was constructed. The calibration curve was used to measure the consistency between the predicted and the actual results. Decision curve analysis (DCA) was used to evaluate its clinical value. The best cut-off value of nomogram score in OS was determined by using X-tile software, and the patients were divided into low-risk, medium-risk, and high-risk groups.ResultsA total of 2,209 EC patients who underwent nCRT were included in further analysis, including 1,549 in the training cohort and 660 in the validation group. By Cox analysis, sex, marital status, T stage, N stage, M stage, and pathological grade were identified as risk factors. A nomogram survival prediction model was established to predict the 36-, 60-, and 84-month survival. The ROC curve and AUC showed that the model had good discrimination ability. The correction curve was in good agreement with the prediction results. DCA further proved the effective clinical value of the nomogram model. The results of X-tile analysis showed that the long-term prognosis of patients in the low-risk subgroup was better in the training cohort and the validation cohort (p &lt; 0.001).ConclusionThis study established an easy-to-use nomogram risk prediction model consisting of independent prognostic factors in EC patients receiving nCRT, helping to stratify risk, identify high-risk patients, and provide personalized treatment options.
Overcoming Poor Transgene Expression in the Wild-Type Chlamydomonas Chloroplast: Creation of Highly Mosquitocidal Strains of Chlamydomonas reinhardtii
Authors: Odom Obed W. , Kang Seongjoon , Ferguson Caleb , Chen Carrie , Herrin David L. 
Published: May 2022

High-level expression of transgenes in the chloroplast of wild-type Chlamydomonas reinhardtii (C. reinhardtii) remains challenging for many genes (e.g., the cry toxin genes from Bacillus thuringiensis israelensis). The bottleneck is presumed to be post-transcriptional and mediated by the 5′ element and the coding region. Using 5′ elements from highly expressed photosynthesis genes such as atpA did not improve the outcome with cry11A regardless of the promoter. However, when we employed the 5′ UTR from mature rps4 mRNA with clean fusions to promoters, production of the rCry11A protein became largely promoter-dependent. The best results were obtained with the native 16S rrn promoter (−91 to −1). When it was fused to the mature 5′ rps4 UTR, rCry11A protein levels were ~50% higher than was obtained with the inducible system, or ~0.6% of total protein. This level was sufficient to visualize the 73-kDa rCry11A protein on Coomassie-stained gels of total algal protein. In addition, analysis of the expression of these transgenes by RT-PCR indicated that RNA levels roughly correlated with protein production. Live cell bioassays using the best strains as food for 3rd instar Aedes aegypti larvae showed that most larvae were killed even when the cell concentration was as low as 2 × 104 cells/mL. Finally, the results indicate that these highly toxic strains are also quite stable, and thus represent a key milestone in using C. reinhardtii for mosquito control.
Korelasi Screen Time Selama Pandemi Covid-19 Dengan Kualitas Tidur Pada Mahasiswa S1-Ilmu Keperawatan Itkes Wiyata Husada Samarinda
Authors: Putri Oktavia Darwito , Sinaga Sumiati , Sumiati Sumiati , Abiyoga Aries 
Published: May 2022

Latar Belakang: Pemberlakuan kebijakan social distancing menjadi dasar kebijakan pendidikan untuk belajar dari rumah atau pembelajaran daring. Kebijakan ini berdampak pada meningkatnya screen time pada mahasiswa. Selain itu, mahasiswa juga berusaha menghabiskan waktu dirumah dengan memanfaatkan aktivitas untuk bermain gadget atau menonton. Meningkatnya screen time dapat mempengaruhi kualitas tidur seseorang. Metode : Penelitian ini merupakan penelitian kuantitatif dengan rancangan deskriptif analitik dan pendekatan cross sectional. Sampel pada penelitian ini sebanyak 88 responden yang dipilih menggunakan teknik consecutive sampling, alat ukur yang digunakan pada screen time yaitu lembar observasi dan pada kualitas tidur menggunakan kuesioner PSQI. Hasil penelitian : Hasil uji spearman rank test didapatkan ada korelasi yang bermakna antara screen time dengan kualitas tidur (p-value 0,000, nilai r = 0,395 atau interpretasi lemah, dan arah korelasi positif) dimana semakin tinggi skor screen time maka akan semakin tinggi skor kualitas tidur mahasiswa. Kesimpulan : mahasiswa yang memiliki screen time berlebihan akan berdampak pada kualitas tidur yang berupa gangguan tidur dan disfungsi siang hari
FC1: A Powerful, Non-Deterministic, Symmetric Key Cipher
Authors: Fabbrini Michele 
Published: May 2022

<p> In this paper we describe a <strong>symmetric key algorithm</strong> that offers an <strong>unprecedented grade of confidentiality</strong>. Based on the uniqueness of the modular multiplicative inverse of a positive integer a modulo n and on its computability in a polynomial time, this <strong>non-deterministic cipher</strong> can easily and quickly handle <strong>keys of millions or billions of bits</strong> that an attacker does not even know the length of. <strong>The algorithm’s primary key is the modulo,</strong> while the ciphertext is given by the concatenation of the modular inverse of blocks of plaintext whose length is randomly chosen within a predetermined range. In addition to the full specification, we present <strong>a</strong> <strong>working implementation of it in Julia Programming Language</strong>, accompanied by real examples of encryption and decryption. <br>
</p>
Social Enterprises and The Support for Entrepreneurs with Disabilities for an Inclusive Entrepreneurship Ecosystem: The Case of Turkey
Authors: Gül Özlem , Çelik Asiye Ayben 
Published: May 2022

Persons with disability have the same rights and freedoms as everyone else, yet they have serious difficulties in gaining meaningful employment. Governments are responsible for ensuring social inclusion, accessibility, and equity for the disabled people in employment, but should also encourage them to establish enterprises which will empower them and contribute to their full economic participation. Businesses generally target able-bodied consumers, even though disabled people as the untapped market, comprise around 15% of the world’s population. Social Enterprises (SE) prioritize social impact and social inclusion, but still require a profit contribution for the sustainability of the business. An SE providing inclusive and accessible products and services for disabled consumers can be run more successfully by a disabled entrepreneur who can internalize the disabled needs. Therefore, how disabled entrepreneurs are supported in their country will be a critical factor in their success. The research objective of this study is to reveal the supports provided in Turkey for disabled entrepreneurs in an inclusive entrepreneurial ecosystem. The findings show that support for entrepreneurship was available in financing, investment, education, R&D and consultancy provided by the state and NGOs. However, accessible support for disabled people was limited to İŞKUR and KOSGEB. Disabled entrepreneurs whose SE targeted disabled consumers were examined as good practice and it was concluded that such ventures should be encouraged, whilst NGOs, social entrepreneurship platforms and the state should strengthen the awareness and improve the accessibility of the opportunities and support available for disabled entrepreneurs.
Pyspeckit: A Spectroscopic Analysis and Plotting Package
Authors: Ginsburg Adam , Sokolov Vlas , de Val-Borro Miguel , Rosolowsky Erik , Pineda Jaime E. , Sipőcz Brigitta M. , Henshaw Jonathan D. 
Published: May 2022

Abstract

pyspeckit is a toolkit and library for spectroscopic analysis in Python. We describe the pyspeckit package and highlight some of its capabilities, such as interactively fitting a model to data, akin to the historically widely-used splot function in IRAF. pyspeckit employs the Levenberg–Marquardt optimization method via the mpfit and lmfit implementations, and important assumptions regarding error estimation are described here. Wrappers to use pymc and emcee as optimizers are provided. A parallelized wrapper to fit lines in spectral cubes is included. As part of the astropy affiliated package ecosystem, pyspeckit is open source and open development, and welcomes input and collaboration from the community.
Correlated Read Noise Reduction in Infrared Arrays Using Deep Learning
Authors: Payeur Guillaume , Artigau Étienne , Levasseur Laurence Perreault , Doyon René 
Published: May 2022

Abstract
We present a new procedure rooted in deep learning to construct science images from data cubes collected by astronomical instruments using HxRG detectors in low-flux regimes. It improves on the drawbacks of the conventional algorithms to construct 2D images from multiple readouts by using the readout scheme of the detectors to reduce the impact of correlated readout noise. We train a convolutional recurrent neural network on simulated astrophysical scenes added to laboratory darks to estimate the flux on each pixel of science images. This method achieves a reduction of the noise on constructed science images when compared to standard flux-measurement schemes (correlated double sampling, up-the-ramp sampling), which results in a reduction of the error on the spectrum extracted from these science images. Over simulated data cubes created in a low signal-to-noise ratio regime where this method could have the largest impact, we find that the error on our constructed science images falls faster than a

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decay, and that the spectrum extracted from the images has, averaged over a test set of three images, a standard error reduced by a factor of 1.85 in comparison to the standard up-the-ramp pixel sampling scheme. The code used in this project is publicly available on GitHub
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https://github.com/GuillaumePayeur/HxRG-denoiser
A Near-infrared Look at AGN Feedback in Bulgeless Galaxies
Authors: Bohn Thomas , Canalizo Gabriela , Satyapal Shobita , Sales Laura V. 
Published: May 2022

Abstract
While it is generally believed that supermassive black holes (SMBHs) lie in most galaxies with bulges, few SMBHs have been confirmed in bulgeless galaxies. Identifying such a population could provide important insights to the BH seed population and secular BH growth. To this end, we obtained near-infrared (NIR) spectroscopic observations of a sample of low-redshift bulgeless galaxies with mid-infrared colors suggestive of active galactic nuclei (AGNs). We find additional evidence of AGN activity (such as coronal lines and broad permitted lines) in 69% (9/13) of the sample, demonstrating that mid-infrared selection is a powerful tool to detect AGNs. More than half of the galaxies with confirmed AGN activity show fast outflows in [O iii] in the optical and/or [Si vi] in the NIR, with the latter generally having much faster velocities that are also correlated to their spatial extent. We are also able to obtain virial BH masses for some targets and find they fall within the scatter of other late-type galaxies in the M
BH–M
stellar relation. The fact that they lack a significant bulge component indicates that secular processes, likely independent of major mergers, grew these BHs to supermassive sizes. Finally, we analyze the rotational gas kinematics and find two notable exceptions: two AGN hosts with outflows that appear to be rotating faster than expected. There is an indication that these two galaxies have stellar masses significantly lower than expected from their dark matter halo masses. This, combined with the observed AGN activity and strong gas outflows, may be evidence of the effects of AGN feedback.
Termination Shocks and the Extended X-Ray Emission in Mrk 78
Authors: Fornasini Francesca M. , Elvis Martin , Maksym W. Peter , Fabbiano Giuseppina , Bergmann Thaisa Storchi , Gandhi Poshak , Whittle Mark 
Published: May 2022

Abstract
Subarcsecond imaging of the X-ray emission in the type 2 active galactic nucleus (AGN) Mrk 78 with Chandra shows complex structure with spectral variations on scales from ∼200 pc to ∼2 kpc. Overall the X-ray emission is aligned E–W with the radio (3.6 cm) and narrow emission line region as mapped in [O iii], with a marked E–W asymmetry. The eastern X-ray emission is mostly in a compact knot coincident with the location where the radio source is deflected, while the western X-ray emission forms a loop or shell ∼2 kpc from the nucleus with radius ∼0.7 kpc. There is suggestive evidence of shocks in both the eastern knot and the western arc. Both these positions coincide with large changes in the velocities of the [O iii] outflow. We discuss possible reasons why the X-ray shocks on the western side occur ∼1 kpc farther out than on the eastern side. We estimate that the thermal energy injected by the shocks into the interstellar medium corresponds to 0.05%–0.6% of the AGN bolometric luminosity.
Implications of a Temperature-dependent Initial Mass Function. I. Photometric Template Fitting
Authors: Sneppen Albert , Steinhardt Charles L. , Hensley Hagan , Jermyn Adam S. , Mostafa Basel , Weaver John R. 
Published: May 2022

Abstract
A universal stellar initial mass function (IMF) should not be expected from theoretical models of star formation, but little conclusive observational evidence for a variable IMF has been uncovered. In this paper, a parameterization of the IMF is introduced into photometric template fitting of the COSMOS2015 catalog. The resulting best-fit templates suggest systematic variations in the IMF, with most galaxies exhibiting top-heavier stellar populations than in the Milky Way. At fixed redshift, only a small range of IMFs are found, with the typical IMF becoming progressively top-heavier with increasing redshift. Additionally, subpopulations of ULIRGs, quiescent and star-forming galaxies are compared with predictions of stellar population feedback and show clear qualitative similarities to the evolution of dust temperatures.
Slow Magnetoacoustic Oscillations in Stellar Coronal Loops
Authors: Lim Daye , Nakariakov Valery M. , Moon Yong-Jae 
Published: May 2022

Abstract
Slow magnetoacoustic oscillations in stellar coronal loops with gravitational stratification are analyzed with a numerical solution of the boundary value problem for eigenvalues and eigenfunctions. In this study, we only focus on the resonant periods. The effects of the gravitational stratification, star mass, loop temperature, and loop length on the properties of slow magnetoacoustic oscillations are investigated. It is shown that the discrepancy between stratified and nonstratified loops is higher in density perturbations than in velocity perturbations. When the star has a larger mass, higher coronal temperature, and longer loop, the density perturbations in the stratified loop are significantly different from the harmonic functions. The periods in the stratified loop are slightly longer than in the nonstratified loop. The periods calculated in our model (14–644 minutes) are consistent with the periods of stellar quasi-periodic pulsations observed in both soft X-rays (2–70 minutes) and white lights (8–390 minutes).
Longitudinal Variation of H2O Ice Absorption on Miranda
Authors: DeColibus Riley A. , Chanover Nancy J. , Cartwright Richard J. 
Published: May 2022

Abstract
Many tidally locked icy satellites in the outer solar system show leading/trailing hemispherical asymmetries in the strength of near-infrared (NIR) H2O ice absorption bands, in which the absorption bands are stronger on the leading hemisphere. This is often attributed to a combination of magnetospheric irradiation effects and impact gardening, which can modify grain size, expose fresh ice, and produce dark contaminating compounds that reduce the strength of absorption features. Previous research identified this leading/trailing asymmetry on the four largest classical Uranian satellites but did not find a clear leading/trailing asymmetry on Miranda, the smallest and innermost classical moon. We undertook an extensive observational campaign to investigate variations of the NIR spectral signature of H2O ice with longitude on Miranda’s northern hemisphere. We acquired 22 new spectra with the TripleSpec spectrograph on the ARC 3.5 m telescope and four new spectra with GNIRS on Gemini North. Our analysis also includes three unpublished and seven previously published spectra taken with SpeX on the 3 m IRTF. We confirm that Miranda has no substantial leading/trailing hemispherical asymmetry in the strength of its H2O ice absorption features. We additionally find evidence for an anti-Uranus/sub-Uranus asymmetry in the strength of the 1.5 μm H2O ice band that is not seen on the other Uranian satellites, suggesting that additional endogenic or exogenic processes influence the longitudinal distribution of H2O ice band strengths on Miranda.
A new subspecies of the Asiatic softshell turtle Amyda ornata (Gray, 1861) from its northern distribution range
Authors: Praschag Peter , Gemel Richard 
Published: May 2022

We describe a new subspecies ofAmyda ornata(Gray, 1861) from the southeastern parts of Bangladesh (Chittagong hill tracts), adjacent regions of north-eastern India (Mizoram, Assam and Tripura) and Myanmar, based on morphological characteristics. The holotype comprises some skeletal elements held by the Natural History Museum of Vienna; the five paratypes consist of living specimens in the private collection of PP “Turtle Island” (a turtle conservation zoo in Graz, Austria). After the genetic identity had been determined in a previous investigation, the morphological description was carried out by examining living specimens and photo documents; and additionally, by evaluating the computed tomography of further living animals with exact location data.Amyda ornata jonglissp. nov. differs from the otherAmyda ornatasubspecies mainly by its relatively compact and stout head in subadults and adults, its paler, greyish and less contrasting colouration missing distinct bright yellow pigments, ochre-coloured irises, and the existence of more distinct tubercles in the neck region and in the posterior section of the carapace than both other subspecies ofAmyda ornata. The tubercles along the front of the carapace protrude clearly in subadult and adult specimens. This softshell turtle is heavily exploited within its limited distribution. Therefore, special comments on conservation aspects are given together with a final discussion on distribution and systematics.
Far di una chiesa un «vero santuario»
Authors: Serra Alessandro 
Published: May 2022

Tramite l’esame di fonti istituzionali, come gli atti della Visita apostolica di Urbano VIII (1624-1630) e gli inventari dei luoghi pii redatti dopo Concilio Romano del 1725, nonché di un singolare caso di ego-document, i diari di Camillo Cybo, il saggio ricostruisce l’evolversi dell’atteggiamento delle confraternite romane verso le reliquie, con un’attenzione specifica per gli articolati meccanismi di socialità ad esso legati. Se tra fine Cinquecento e metà Seicento si riscontra un approccio sostanzialmente « devozionale » ai sacri resti, dai primi decenni del XVIII secolo, si assiste all’affermarsi progressivo di una tendenza all’accumulo indiscriminato. Si tratta di percorsi diversi, ma accomunati dalla volontà di attribuire agli spazi confraternali quel surplus di sacralità indispensabile a conferire loro una specificità nella complessa topografia religiosa complessa romana.
Quand le musée de société donne du pouvoir : enjeux de la construction participative d’expositions au Mucem
Authors: Ferloni Julia , Sitzia Emilie 
Published: May 2022

Les pratiques participatives sont un outil particulièrement important et sollicité dans les musées de société : aux prises avec le contemporain, ils portent une responsabilité de représentation de la société dans son entièreté, sa diversité et sa complexité. Il est en effet présumé que la participation sous toutes ses formes et à des degrés divers est la manière la plus adaptée et positive pour parvenir à une inclusion réussie. Nous proposons avec cet article d’explorer les enjeux de l’inclusion des représentants de la société civile dans des projets muséaux, ceux du Mucem en particulier. Les questions centrales sont les suivantes : y a-t-il un réel bénéfice à donner la parole et, partant, le/du pouvoir, à des citoyens ? Et pour qui ? Quels sont les obstacles rencontrés dans la co-création d’exposition avec des non-spécialistes du musée ?
Multifocal lymphadenopathies with polyclonal reactions primed after EBV infection in a mRNA-1273 vaccine recipient
Authors: Girardin François R. , Tzankov Alexandar , Pantaleo Giuseppe , Livio Françoise , Greub Gilbert 
Published: May 2022

We report a case of recurrent tender, multifocal lymphadenopathies associated with B-symptoms, clinically mimicking lymphoma in a mRNA-1273 vaccine recipient after a recent Epstein-Barr virus (EBV) infection.
In the lymph node biopsy, monocytoid B-cell hyperplasia, TH2 (GATA3+) predominance, and hyperplasia of interferon-gamma-producing plasmacytoid dendritic cells were observed along with sustained neutralising antibody production against SARS-CoV-2 wild-type and five variants. High titres of anti-S antibodies and neutralising antibodies were observed, excepted for variant B.1.529** (omicron) and B.1.351** (beta), due to several mutations in the spike protein, including the E484K mutation.
We postulated that EBV acted as an immunological enhancer with the mRNA-1273 vaccine, inducing a sustained inflammatory response over several weeks. However, the polyclonal nature of the lymphadenopathy with polytypic plasmacytosis and pseudo-tumoural reaction cell hyperplasia were associated with failure to mount acute phase responses.