bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generalized uncertainty relations for multiple measurements
Authors: Wu Lin , Song Xue-Ke , Ye Liu , Wang Dong 
Published: August 2022

AbstractThe uncertainty relation is regarded as a remarkable feature of quantum mechanics differing from the classical counterpart, and it plays a backbone role in the region of quantum information theory. In principle, the uncertainty relation offers a nontrivial limit to predict the outcome of arbitrarily incompatible observed variables. Therefore, to pursue a more general uncertainty relations ought to be considerably important for obtaining accurate predictions of multi-observable measurement results in genuine multipartite systems. In this article, we derive a generalized entropic uncertainty relation (EUR) for multi-measurement in a multipartite framework. It is proved that the bound we proposed is stronger than the one derived from Renes et al. in [Phys. Rev. Lett. 103,020402(2009) ] for the arbitrary multipartite case. As an illustration, we take several typical scenarios that confirm that our proposed bound outperforms that presented by Renes et al. Hence, we believe our findings provide generalized uncertainty relations with regard to multi-measurement setting, and facilitate the EUR’s applications on quantum precision measurement regarding genuine multipartite systems.
New insights into pathogen-mediated modulation of host RNA splicing
Authors: Gao Chuyun , Dong Suomeng 
Published: August 2022

AbstractAlternative splicing (AS) regulation of pre-mRNA has been proven to be one of the fundamental layers of plant immune system. How pathogens disrupt plant AS process to suppress plant immunity by secreted effectors remain poorly understood. In the recent study, Gui et al. revealed that a previously identified effector PSR1 of Phytophthora interferes with host RNA splicing machinery to modulate small RNA biogenesis, leading to compromised plant immunity. The study provided a novel insight into the importance of AS process during pathogen-host interactions.
Advancing diversity, equity, and inclusion within clinical and translational science training programs: A qualitative content analysis of the training breakout session at the national CTSA program meeting
Authors: Shay L. Aubree , Schmidt Susanne , Thurston Addison J. , Campbell Jennifer A. , Dawson Aprill Z. , Egede Leonard E. , Ozieh Mukoso N. , Phillips Shane A. , Walker Rebekah J. , Williams Joni S. , Tsevat Joel 
Published: August 2022

Abstract

Background:
Diversity, equity, and inclusion (DEI) in clinical and translational science (CTS) are paramount to driving innovation and increasing health equity. One important area for improving diversity is among trainees in CTS programs. This paper reports on findings from a special session at the November 2020 Clinical and Translational Science Award (CTSA) national program meeting that focused on advancing diversity and inclusion within CTS training programs.

Methods:
Using qualitative content analysis, we identified approaches brought forth to increase DEI in KL2 career development and other training programs aimed at early-stage CTS investigators, beyond the six strategies put forth to guide the breakout session (prioritizing representation, building partnerships, making it personal, designing program structure, improving through feedback, and winning endorsement). We used an inductive qualitative content analysis approach to identify themes from a transcript of the panel of KL2 program leaders centered on DEI in training programs.

Results:
We identified four themes for advancing DEI within CTS training programs: 1) institutional buy-in; 2) proactive recruitment efforts; 3) an equitable application process; and 4) high-quality, diverse mentorship.

Conclusion:
Implementing these strategies in CTS and other training programs will be an important step for advancing DEI. However, processes need to be established to evaluate the implementation and effectiveness of these strategies through continuous quality improvement, a key component of the CTSA program. Training programs within the CTSA are well-positioned to be leaders in this critical effort to increase the diversity of the scientific workforce.
Autism spectrum disorders: current issues and future directions
Authors: Gallagher L. , McGrath J. 
Published: August 2022

AbstractThis edition of Irish Journal of Psychological Medicine is a Special Themed Issue on Autism Spectrum Disorders (ASD). Mental health services are not currently meeting the needs of autistic people across the lifespan. We have limited evidence based treatments for core symptoms and comorbidities and there is lack of awareness and under-recognition of ASD, particularly in adults and certain groups of individuals. The key themes in this edition focus on challenges with recognition and diagnosis and address these from both clinical and research perspectives. Co-occurring conditions also feature, which are also under-recognised and can contribute to less optimal outcomes. New and existing research developments in stratification for clinical trials and neuroimaging are also discussed. We hope this Issue highlights relevant current issues in ASD, and provides insights which can help address the challenges in providing evidence based pathways to better meet the needs of autistic people into the future.
Developing the Patient Falls Risk Report: A Mixed-Methods Study on Sharing Falls-Related Clinical Information from Home Care with Primary Care Providers
Authors: Nova Amanda A. , Heckman George , Giangregorio Lora M. , Alarakhia Mohamed 
Published: August 2022

AbstractIf interRAI home care information were shared with primary care providers, care provision and integration could be enhanced. The objective of this study was to co-develop an interRAI-based clinical information sharing tool (i.e., the Patient Falls Risk Report) with a sample of primary care providers. This mixed-methods study employed semi-structured interviews to inform the development of the Patient Falls Risk Report and online surveys based on the System Usability Scale instrument to test its usability. Most of the interview sample (n = 9) believed that the report could support patient care by sharing relevant and actionable falls-related information. However, criticisms were identified, including insufficient detail, clarity, and support for shared care planning. After incorporating suggestions for improvement, the survey sample (n = 27) determined that the report had excellent usability with an overall usability score of 83.4 (95% CI = 78.7–88.2). By prioritizing the needs of end-users, sustainable interRAI interventions can be developed to support primary care.
Migration response to drought in Mali. An analysis using panel data on Malian localities over the 1987-2009 period
Authors: Defrance Dimitri , Delesalle Esther , Gubert Flore 
Published: August 2022

AbstractThis paper combines population and climate data to estimate the volume of migration induced by the drought events that have hit Mali since the late 1980s. The results show that droughts have had the effect of decreasing net migration rates in the affected localities. This is true for both men and women, regardless of their age. The effect of drought episodes, however, is found to differ according to localities and households’ capacity to adapt to climatic constraints: it fades in localities characterized by more diversified crops and in areas that receive more rainfall on average. Climate shocks also had an impact on international mobility: over the 2004–2009 period, around 2300 additional departures per year can be attributed to the droughts that hit Mali during the 2000s. We forecast that, under different climate scenarios and population growth projections, mobility induced by drought events will substantially grow in the next decades.
Modelling the burden of long-term care for institutionalised elderly based on care duration and intensity
Authors: Bladt Martin , Fuino Michel , Shemendyuk Aleksandr , Wagner Joël 
Published: August 2022

AbstractThe financing of long-term care and the planning of care capacity are of increasing interest due to demographic changes and the ageing population in many countries. Since many care-intensive conditions begin to manifest at higher ages, a better understanding and assessment of the expected costs, required infrastructure, and number of qualified personnel are essential. To evaluate the overall burden of institutional care, we derive a model based on the duration of stay in dependence and the intensity of help provided to elderly individuals. This article aims to model both aspects using novel longitudinal data from nursing homes in the canton of Geneva in Switzerland. Our data contain comprehensive health and care information, including medical diagnoses, levels of dependence, and physical and psychological impairments on 21,758 individuals. We build an accelerated failure time model to study the influence of selected factors on the duration of care and a beta regression model to describe the intensity of care. We show that apart from age and gender, the duration of stay before death is mainly affected by the underlying diseases and the number of different diagnoses. Simultaneously, care intensity is driven by the individual level of dependence and specific limitations. Using both evaluations, we approximate the overall care severity for individual profiles. Our study sheds light on the relevant medical, physical, and psychological health indicators that need to be accounted for, not only by care providers but also by policy-makers and insurers.
The Impact of Emotional versus Instrumental Reasons for Dual Citizenship on the Perceived Loyalty and Political Tolerance of Immigrant-Origin Minorities
Authors: Verkuyten Maykel , Gale Jessica , Yogeeswaran Kumar , Adelman Levi 
Published: August 2022

AbstractAn increasing number of states permit dual citizenship, but there are public concerns about divided loyalties of dual citizens which might lead to intolerance of their political rights. We propose and test whether these concerns depend on the emotional versus instrumental reasons immigrants express for acquiring their second, host society citizenship. Using a survey experiment on a nationally representative sample of native-born Dutch, we find that emotional (vs. instrumental) reasons for a second citizenship lead to higher perceived host society loyalty, which is related to greater political tolerance of dual citizens. Instrumental reason for dual citizenship leads to higher perceived loyalty to the country of origin; however, this is not related to political tolerance of such dual citizens. Implications for theory and society are considered.
Sea Spray Impacts on Tropical Cyclone Olwyn Using a Coupled Atmosphere‐Ocean‐Wave Model
Authors: Xu Xingkun , Voermans Joey Jeff , Moon Il‐Ju , Liu Qingxiang , Guan Changlong , Babanin Alexander V. 
Published: August 2022

AbstractExtreme marine weather enhances the production of sea spray droplets which, in turn, affect the air‐sea fluxes. Despite the ability of sea spray to modulate air‐sea interaction processes, it remains under‐represented in tropical cyclone (TC) forecasting modeling. In this study, impacts of sea spray on the atmospheric and oceanic environments of TC Olwyn are investigated. This is achieved by high‐resolution nested simulations using an air‐sea‐wave model coupled with a sea spray production model. We compared two different sea spray models: a wave‐Reynolds‐number‐dependent model, and a wave‐steepness‐dependent spray model. By including a sea spray model, the root mean square error in the simulated TC Olwyn 10 m wind and significant wave height are significantly reduced by up to 30% and 26%, respectively, in comparison to the baseline simulation without spray. This improvement is because sea spray decreases air‐sea heat fluxes at larger radii of TC, and increases air‐sea heat fluxes at smaller radii of TC. In contrast to the simulated results without sea spray, sea spray increases the air‐sea heat (sensible + latent) energy transfer and intensifies TC Olwyn. Sea spray also triggers stronger upper‐ocean mixing and strengthens the TC‐induced sea surface temperature cooling. Our results thus imply that sea spray critically impacts the atmosphere and ocean conditions during extreme marine weather and thus needs to be considered explicitly in TC forecasting modeling.
Generalisable 3D printing error detection and correction via multi-head neural networks
Authors: Brion Douglas A. J. , Pattinson Sebastian W. 
Published: August 2022

AbstractMaterial extrusion is the most widespread additive manufacturing method but its application in end-use products is limited by vulnerability to errors. Humans can detect errors but cannot provide continuous monitoring or real-time correction. Existing automated approaches are not generalisable across different parts, materials, and printing systems. We train a multi-head neural network using images automatically labelled by deviation from optimal printing parameters. The automation of data acquisition and labelling allows the generation of a large and varied extrusion 3D printing dataset, containing 1.2 million images from 192 different parts labelled with printing parameters. The thus trained neural network, alongside a control loop, enables real-time detection and rapid correction of diverse errors that is effective across many different 2D and 3D geometries, materials, printers, toolpaths, and even extrusion methods. We additionally create visualisations of the network’s predictions to shed light on how it makes decisions.
Atomic-scale 3D imaging of individual dopant atoms in an oxide semiconductor
Authors: Hunnestad K. A. , Hatzoglou C. , Khalid Z. M. , Vullum P. E. , Yan Z. , Bourret E. , van Helvoort A. T. J. , Selbach S. M. , Meier D. 
Published: August 2022

AbstractThe physical properties of semiconductors are controlled by chemical doping. In oxide semiconductors, small variations in the density of dopant atoms can completely change the local electric and magnetic responses caused by their strongly correlated electrons. In lightly doped systems, however, such variations are difficult to determine as quantitative 3D imaging of individual dopant atoms is a major challenge. We apply atom probe tomography to resolve the atomic sites that donors occupy in the small band gap semiconductor Er(Mn,Ti)O3 with a nominal Ti concentration of 0.04 at. %, map their 3D lattice positions, and quantify spatial variations. Our work enables atomic-level 3D studies of structure-property relations in lightly doped complex oxides, which is crucial to understand and control emergent dopant-driven quantum phenomena.
Precision dynamical mapping using topological data analysis reveals a hub-like transition state at rest
Authors: Saggar Manish , Shine James M. , Liégeois Raphaël , Dosenbach Nico U. F. , Fair Damien 
Published: August 2022

AbstractIn the absence of external stimuli, neural activity continuously evolves from one configuration to another. Whether these transitions or explorations follow some underlying arrangement or lack a predictable ordered plan remains to be determined. Here, using fMRI data from highly sampled individuals (~5 hours of resting-state data per individual), we aimed to reveal the rules that govern transitions in brain activity at rest. Our Topological Data Analysis based Mapper approach characterized a highly visited transition state of the brain that acts as a switch between different neural configurations to organize the spontaneous brain activity. Further, while the transition state was characterized by a uniform representation of canonical resting-state networks (RSNs), the periphery of the landscape was dominated by a subject-specific combination of RSNs. Altogether, we revealed rules or principles that organize spontaneous brain activity using a precision dynamics approach.
Distractibility and impulsivity neural states are distinct from selective attention and modulate the implementation of spatial attention
Authors: Amengual J. L. , Di Bello F. , Ben Hadj Hassen S. , Ben Hamed Suliann 
Published: August 2022

AbstractIn the context of visual attention, it has been classically assumed that missing the response to a target or erroneously selecting a distractor occurs as a consequence of the (miss)allocation of attention in space. In the present paper, we challenge this view and provide evidence that, in addition to encoding spatial attention, prefrontal neurons also encode a distractibility-to-impulsivity state. Using supervised dimensionality reduction techniques in prefrontal neuronal recordings in monkeys, we identify two partially overlapping neuronal subpopulations associated either with the focus of attention or overt behaviour. The degree of overlap accounts for the behavioral gain associated with the good allocation of attention. We further describe the neural variability accounting for distractibility-to-impulsivity behaviour by a two dimensional state associated with optimality in task and responsiveness. Overall, we thus show that behavioral performance arises from the integration of task-specific neuronal processes and pre-existing neuronal states describing task-independent behavioral states.
Nitrogen isotope evidence for Earth’s heterogeneous accretion of volatiles
Authors: Shi Lanlan , Lu Wenhua , Kagoshima Takanori , Sano Yuji , Gao Zenghao , Du Zhixue , Liu Yun , Fei Yingwei , Li Yuan 
Published: August 2022

AbstractThe origin of major volatiles nitrogen, carbon, hydrogen, and sulfur in planets is critical for understanding planetary accretion, differentiation, and habitability. However, the detailed process for the origin of Earth’s major volatiles remains unresolved. Nitrogen shows large isotopic fractionations among geochemical and cosmochemical reservoirs, which could be used to place tight constraints on Earth’s volatile accretion process. Here we experimentally determine N-partitioning and -isotopic fractionation between planetary cores and silicate mantles. We show that the core/mantle N-isotopic fractionation factors, ranging from −4‰ to +10‰, are strongly controlled by oxygen fugacity, and the core/mantle N-partitioning is a multi-function of oxygen fugacity, temperature, pressure, and compositions of the core and mantle. After applying N-partitioning and -isotopic fractionation in a planetary accretion and core–mantle differentiation model, we find that the N-budget and -isotopic composition of Earth’s crust plus atmosphere, silicate mantle, and the mantle source of oceanic island basalts are best explained by Earth’s early accretion of enstatite chondrite-like impactors, followed by accretion of increasingly oxidized impactors and minimal CI chondrite-like materials before and during the Moon-forming giant impact. Such a heterogeneous accretion process can also explain the carbon–hydrogen–sulfur budget in the bulk silicate Earth. The Earth may thus have acquired its major volatile inventory heterogeneously during the main accretion phase.
SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP
Authors: Chau Jocelyn E. , Vish Kimberly J. , Boggon Titus J. , Stiegler Amy L. 
Published: August 2022

AbstractRhoGAP proteins are key regulators of Rho family GTPases and influence a variety of cellular processes, including cell migration, adhesion, and cytokinesis. These GTPase activating proteins (GAPs) downregulate Rho signaling by binding and enhancing the intrinsic GTPase activity of Rho proteins. Deleted in liver cancer 1 (DLC1) is a tumor suppressor and ubiquitously expressed RhoGAP protein; its activity is regulated in part by binding p120RasGAP, a GAP protein for the Ras GTPases. In this study, we report the co-crystal structure of the p120RasGAP SH3 domain bound directly to DLC1 RhoGAP, at a site partially overlapping the RhoA binding site and impinging on the catalytic arginine finger. We demonstrate biochemically that mutation of this interface relieves inhibition of RhoGAP activity by the SH3 domain. These results reveal the mechanism for inhibition of DLC1 RhoGAP activity by p120RasGAP and demonstrate the molecular basis for direct SH3 domain modulation of GAP activity.
PIF4 enhances DNA binding of CDF2 to co-regulate target gene expression and promote Arabidopsis hypocotyl cell elongation
Authors: Gao He , Song Wen , Severing Edouard , Vayssières Alice , Huettel Bruno , Franzen Rainer , Richter René , Chai Jijie , Coupland George 
Published: August 2022

AbstractHow specificity is conferred within gene regulatory networks is an important problem in biology. The basic helix–loop–helix PHYTOCHROME-INTERACTING FACTORs (PIFs) and single zinc-finger CYCLING DOF FACTORs (CDFs) mediate growth responses of Arabidopsis to light and temperature. We show that these two classes of transcription factor (TF) act cooperatively. CDF2 and PIF4 are temporally and spatially co-expressed, they interact to form a protein complex and act in the same genetic pathway to promote hypocotyl cell elongation. Furthermore, PIF4 substantially strengthens genome-wide occupancy of CDF2 at a subset of its target genes. One of these, YUCCA8, encodes an auxin biosynthesis enzyme whose transcription is increased by PIF4 and CDF2 to contribute to hypocotyl elongation. The binding sites of PIF4 and CDF2 in YUCCA8 are closely spaced, and in vitro PIF4 enhances binding of CDF2. We propose that this occurs by direct protein interaction and because PIF4 binding alters DNA conformation. Thus, we define mechanisms by which PIF and CDF TFs cooperate to achieve regulatory specificity and promote cell elongation in response to light.
The microbiome of a bacterivorous marine choanoflagellate contains a resource-demanding obligate bacterial associate
Authors: Needham David M. , Poirier Camille , Bachy Charles , George Emma E. , Wilken Susanne , Yung Charmaine C. M. , Limardo Alexander J. , Morando Michael , Sudek Lisa , Malmstrom Rex R. , Keeling Patrick J. , Santoro Alyson E. , Worden Alexandra Z. 
Published: August 2022

AbstractMicrobial predators such as choanoflagellates are key players in ocean food webs. Choanoflagellates, which are the closest unicellular relatives of animals, consume bacteria and also exhibit marked biological transitions triggered by bacterial compounds, yet their native microbiomes remain uncharacterized. Here we report the discovery of a ubiquitous, uncultured bacterial lineage we nameCandidatusComchoanobacterales ord. nov., related to the human pathogenCoxiellaand physically associated with the uncultured marine choanoflagellateBicosta minor. We analyse complete ‘Comchoano’ genomes acquired after sorting singleBicostacells, finding signatures of obligate host-dependence, including reduction of pathways encoding glycolysis, membrane components, amino acids and B-vitamins. Comchoano encode the necessary apparatus to import energy and other compounds from the host, proteins for host-cell associations and a type IV secretion system closest toCoxiella’sthat is expressed in Pacific Ocean metatranscriptomes. Interactions between choanoflagellates and their microbiota could reshape the direction of energy and resource flow attributed to microbial predators, adding complexity and nuance to marine food webs.