bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Dementia and Patient Outcomes among COVID-19 Patients: A Multi-center Rétrospective Case-Control Study
Authors: H Vekaria Pratikkumar , Syed Areej , Anderson Jeffrey , Cornett Brendon , Bourbia Amine , G Flynn Michael , Kashyap Rahul , R Shah Asif 
Published: August 2022

BACKGROUND

We conducted a retrospective cohort study on COVID-19 patients with and without dementia by extracting data from the HCA Healthcare Enterprise Data Warehouse between January-September 2020.

AIMS

To describe the role of patients' baseline characteristics specifically dementia in determining overall health outcomes in COVID-19 patients.

METHODS

We grouped in-patients who had ICD-10 codes for dementia (DM) with age and gender-matched (1:2) patients without dementia (ND). Our primary outcome variables were in-hospital mortality, length of stay, Intensive Care Unit (ICU) admission, ICU-free days, mechanical ventilation (MV) use, MV-free days and 90-day re-admission.

RESULTS

Matching provided similar age and sex in DM and ND groups. BMI (median, 25.8 vs. 27.6) and proportion of patients who had smoked (23.3% vs. 31.3%) were lower in DM than in ND patients. The median (IQR) Elixhauser Comorbidity Index was higher in dementia patients 7 (5-10) vs. 5 (3-7, p < 0.01). Higher mortality was observed in DM group (30.8%) vs. ND group (26.4%, p < 0.01) as an unadjusted univariate analysis. The 90-day readmission was not different (32.1% vs. 31.8%, p=0.8). In logistic regression analysis, the odds of dying were not different between patients in DM and ND groups (OR=1.0; 95% CI 0.86-1.17), but the odds of ICU admissions were significantly lower for dementia patients (OR=0.58, 95% CI 0.51-0.66).

CONCLUSIONS

Our data showed that COVID-19 patients with dementia did not fare substantially worse, but in fact, fared better when certain metrics were considered.
Rancang Ulang Prototipe Pembangkit Listrik Tenaga Piko Hidro Portabel Tipe Cross Flow
Authors: Suseno Bella Maharani Marcellia 
Published: August 2022

Listrik merupakan salah satu kebutuhan yang terpenting dalam kehidupan sehari-hari. Kebutuhan penerangan untuk keperluan studi atau riset di lapangan yang belum terjangkau sumber listrik menjadikan Pembangkit Listrik Tenaga Piko Hidro (PLTPH) portabel sebagai salah satu solusi dalam mendapatkan pasokan listrik dengan memanfaatkan sumber air dengan debit dan head yang cukup kecil. Langkah yang telah dilakukan pada rancang bangun PLTPH portabel meliputi kajian terhadap PLTPH yang pernah dirancang oleh Dzulfikri (2021), dilakukan rancang ulang terhadap bagian-bagian alat PLTPH portabel seperti saluran masuk dan keluar, bentuk rumah turbin, penyangga, runner turbin, instalasi pengujian, dan luas penampang saluran nozel. Selanjutnya menyiapkan instalasi pengujian. Dilakukan proses pengujian dan dilanjutkan pembahasan hasil pengujian. Didapatkan dimensi alat dengan panjang 266,63 mm, lebar 190 mm, dan tinggi 226,88 mm yang dibuat menggunakan mesin 3D Printing yang menggunakan bahan plastik PLA. Capaian dari hasil pengujian hasil rancang ulang memiliki kecepatan putaran sebesar 794 rpm, debit sebesar 3,867 l/s, dan head 2 m, sehingga menghasilkan daya mekanik sebesar 20,13 W dan efisiensi sebesar 26,0%. Hasil tersebut menghasilkan daya dan efisiensi mekanik yang lebih besar daripada alat eksisting (daya mekanik sebesar 11,7 W dan efisiensi sebesar 23%).
Kata-kata kunci: PLTPH, Portabel, Rancang Ulang, Cross Flow
The Diversity Species of Medicinal Plants in The Martelu Purba Nature Reserve, North Sumatra
Authors: Rambey Ridahati , Jelly Permana Purba  , Ahmad Baiquni Rangkuti  , Arida Susilowati  , Onrizal  
Published: August 2022

Indonesia was known as a country that has high biodiversity, some of them are various types of medicinal plants. Since the first, Indonesian people have used medicinal plants in traditional medicine. This research was conducted in the Martelu Purba Nature Reserve (MPNR), Purba District, Simalungun Regency, North Sumatra. MPNR is a nature reserve consisting of high biodiversity, some of them are medicinal plants. However, the information on medicinal plants in this area is rarely documented even though they have a meaningful contribution as traditional medical treatments for indigenous communities. This study aims to identify all plant species found in the MPNR. This method of research was carried out by exploring key informants, namely the manager of the nature reserve and the local community. Determination of the number of respondents is done by the snowball sampling method. The results showed that there were 44 species of medicinal plants found in the MPNR consisting of 33 families, where the most families were from the Arecaceae family, which was 17.24%. Based on habitus, medicinal plants found in MPNR consist of 20 tree species (45.45%), 13 herb species (29.54%), 5 palm species (11.36%), 4 shrub species (9.09 %), and 2 species from epiphytes (4,54%). Based on the intended use of medicinal plants used as fever, cough, diarrhea, diabetes, wounds, asthma, malaria, and others. Based on the part of the plant that has been used, 19 species from leaves (42.22%), 7 species from fruit/seed (15.90%), 6 species from all plant parts (13.63%), 5 species from bark (11.36%), 2 species from roots (4.54%), 1 species from resin (9.09%), 1 species from the flower (9.09%), 1 species from bark and seeds (9.09%), 1 species from wood (9 .09%), and 1 species from bark and leaves (9.09%). Medicinal plant species found in the MPNR must be conserved to maintain their sustainability and can be used sustainably.
Potensi Antidiabetik Tepung Terung Ungu (Solanum Melongena L.) pada Tikus Hiperglikemia
Authors: Fajriana Hasmar 
Published: August 2022

Diabetes Mellitus (DM) is a group of metabolic diseases characterized and identified with hyperglycemia due to impaired insulin secretion, insulin action, or both, and the presence of impaired metabolism of carbohydrates, fats, and proteins. IDF data shows the prevalence is increasing from year to year, namely 9.3% (2020) and 10.5% (2021). Treatment of DM was needed a combination of pharmacological and non-pharmacological treatment by utilizing local foods in the diet. Purple eggplant (Solanum melongena L.) is one of the potential plants in Indonesia that is very rich in antioxidants and believed to decrease fasting blood glucose (FBG) levels. The study aimed to determine the effect of purple eggplant flour (TTU) on the weight and fasting blood glucose levels of hyperglycemia rats. This true experimental study design used a pre-post test with a control group design. Thirty-six male Sprague Dawley rats were divided randomly into five groups: KN group (7 rats), KD (8 rats), P1 (7 rats), P2 (7 rats), and P3 (7 rats). The rats used were 10-12 weeks, weighing 207.25±26.76 grams. The hyperglycemia rat model was made by induced NA (230 mg/kg body weight)-STZ (65 mg/kg body weight) intraperitoneally. Intervention in the form of TTU modified feed (standard feed is substituted with TTU according to the dose) was given for 28 days with dose variations of 2.36 grams, 4.71 grams, and 7.07 grams. Body weight and FBG level were measured before and after the intervention. Data were analyzed statistically using One Way Anova test, Bonferroni test, and uji paired t-test. The body weight of DM rats was significantly lower, and FBG levels were significantly higher than normal rats (KN). Orally administration of TTU for 28 days significantly increased body weight (6.59%-19.54%) and reduced levels of FBG (33.04-54.61%). The changes in FBG levels were in line with the increasing doses of intervention. Purple eggplant flour was able to maintain body weight and reduce the levels of FGB hyperglycemia in rats induced by NA-STZ.
PELATIHAN TANGGAP BENCANA BERBASIS MODUL DAN SIMULASI TERHADAP PENGETAHUAN KESIAPSIAGAAN BENCANA
Authors: Iqra Iqra , Tahir Rusna 
Published: August 2022

Indonesia sebagai The Biggest Disaster Laboratory In The World telah menjadi titik acuan pengembangan penanggulangan bencana dengan memaksimalkan pemberdayaan masyarakat secara mandiri khususnya dalam kesiapsiagaan bencana. Kesiapan secara kognitif dan psikis bagi masyarakat dalam menghadapi bencana dapat memberikan peluang menurunnya dampak kerusakan maupun korban yang ditimbulkan dari bencana tersebut. Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan tanggap bencana berbasis modul dan simulasi terhadap pengetahuan kesiapsiagaan masyarakat di Kabupaten Konawe. Desain penelitian ini menggunakan quasy eksperimen dengan pendekatan pre post test with control group. Sampel dikelompokan menjadi 2 dengan jumlah masing-masing 30 responden pada setiap kelompok (intervensi dan kontrol) yang dipilih secara purposive sampling. Data diukur dengan menggunakan kuesioner yang telah dilakukan uji validitas dan reliabilitas. Hasil uji statistik dengan menggunakan Mann-Whitney test menunjukan adanya peningkatan pengetahuan kesiapsiagaan responden setelah diberikan pelatihan dengan menggunakan modul dan simulasi, dimana rata-rata pengetahuan kesiapsiagaan responden kelompok intervensi lebih tinggi dibandingkan dengan kelompok kontrol dengan nilai signifikansi p = 0,001 (p<0,05). Sehingga disimpulkan pelatihan tanggap darurat berbasis modul dan simulasi berpengaruh terhadap pengetahuan kesiapsiagaan.
Pengelolaan Limbah Medis Padat Bahan Berbahaya dan Beracun pada Rumah Sakit Rujukan Covid-19
Authors: Mappau Zrimurti , Hairuddin Miftah Chairani , Akbar Fajar 
Published: August 2022

Waste generated by hospital is categorized as waste containing hazardous materials (B3) which can pose a hazard to the environtment, public health and other living things if disposed of directly into environtment. The purpose of this study was to describe the management of B3 solid medical waste at the Regional General Hospital of West Sulawesi Province as the Covid-19 Patient Referral Hospital. This research is a descriptive study with an observational approach. This research was conducted at the Regional General Hospital of West Sulawesi Province which is the only Covid-19 referral hospital in Mamuju Regency. The sample of this research is the person in charge of medical waste, waste transport officers and third-party medical waste transporters as special Covid-19 patient care rooms. Data collection was carried out by direct observation in the Covid-19 patient care room. The results show that the management has been running in accordance with the SOPs issued by the Ministry of Environmental and the Director of Environmental Health including the waste sorting process is not carried out because all solid waste resulting from the activities of Covid-19 patients is classified as B3 waste. The process of transporting solid waste from the officer’s treatment room uses complete PPE. The waste treatment process is not carried out at the hospital but is handed over to a third party. The process of storing waste in a temporary storage place for B3 waste that has previously been packeged in a special container. The conclusion in this study is that the menagement of B3 solid medical waste at the West Sulawesi Provincial Hospital has been carried out in accordance with the guidlines for managing the waste of the Covid-19 referral hospital.
Multivariate logistic regression analysis of the correlation between five biomarkers and ovarian cancer in patients with intermediate-risk: A prospective cross-sectional study
Authors: Liu Zhen , Wu Jingjing , Wang Xiuli , Ji Xiaoyang 
Published: August 2022

Objective: To find potential diagnostic biomarkers for ovarian cancer (OC), a prospective analysis of the expression of five biomarkers in patients with intermediate-risk and their correlation with the occurrence of OC was conducted.Method: A prospective observational study was carried out, patients who underwent surgical treatment with benign or malignant ovarian tumors in our hospital from January 2020 to February 2021 were included in this study, and a total of 263 patients were enrolled. Based on the postoperative pathological results, enrolled patients were divided into ovarian cancer group and benign tumor group (n = 135). The ovarian cancer group was further divided into a mid-stage group (n = 46) and an advanced-stage group (n = 82). The basic information of the three groups of patients was collected, the preoperative imaging data of the patients were collected to assess the lymph node metastasis, the preoperative blood samples were collected to examine cancer antigen 125 (CA125), carbohydrate antigen 19–9 (CA19–9), Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and the postoperative pathological data were sorted and summarized.Result: The average during of disease in the advanced ovarian cancer group was 0.55 ± 0.18 years higher than the benign tumor group (0.43 ± 0.14 years), p &lt; 0.001. In the advanced ovarian cancer group, the ratio of patients with the tumor, node, metastasis (TNM) stage IV (64.63%), with tumor Grade stage II and III (93.90%), and without lymph node metastasis (64.63%) was respectively more than that in the mid-stage group (accordingly 0.00, 36.96, 23.91%) (p &lt; 0.001); The ratio of patients with TNM grade III in the mid-stage group (73.91%) was more than that in the advanced group (35.37%) (p &lt; 0.001). The levels of the five biomarkers: CA19-9, CA125, NLR, PLR, and BDNF were different among the three groups (p &lt; 0.001).Conclusion: CA19-9, CA125, NLR, PLR, BDNF are five biomarkers related to the occurrence of ovarian cancer and are risk factors for it. These five biomarkers and their Combined-Value may be suitable to apply in the diagnosis and the identification of ovarian cancer in patients with intermediate-risk.
Unraveling the complex burial history of the Antrim formation in Michigan basin using paleomagnetism, rock magnetism and geochemistry
Authors: Heij Gerhard , Elmore Richard Douglas 
Published: August 2022

This paper presents an integrated paleomagnetic, rock magnetic and geochemical study of the Devonian Antrim shale in the Michigan Basin. Specimens were obtained from two unoriented vertical cores (named St. Chester and Krocker) and sampled relative to a master specimen orientation line. Alternating field (AF) demagnetization experiments isolated a lower coercivity component (LC) from 0 to ∼60 mT in the Krocker core and corresponds to a Jurassic (170 Ma ± 25) magnetization. Higher coercivity components (HC) in the Krocker core are unblocked from ∼60 to 120 mT and unlike LC components, occasionally exhibit stable unblocking temperature ranges (e.g., 150–450°C) and higher AF demagnetization ranges (∼60–120 mT). HC components in the Krocker core are unique to certain members within the Antrim shale with a poorly resolved Middle Permian/Late Triassic magnetization in the Paxton member and Late Pennsylvanian (305 Ma ± 10) component in the Norwood. The St. Chester well exhibited a LC component among all specimens with a slightly older (205 Ma ± 10) than the Krocker core. Rock magnetic parameters indicate the magnetization resides in PSD/SD magnetite in both HC and LC components. Overall, the magnetizations are interpreted to be chemical remanent magnetizations (CRMs) with the HC component residing in SD magnetite which formed during hydrothermal activity in both cores. The LC component likely resides in PSD/MD magnetite and is interpreted to have formed in response to fluid flow associated with tectonic uplift and/or hydrocarbon migration. Petrographic observations indicate mineral assemblages consistent with hydrothermal mineralization (e.g., baroque dolomite). Depleted δ18O data from carbonate fractures are consistent with a hydrothermal fluid magnetization mechanism. Consistent anisotropy of magnetic susceptibility (AMS) lineations indicates either a long-lived paleocurrent direction or far-field tectonic shortening originating from the neighboring Acadian orogeny. Inorganic geochemistry indicate that paramagnetic Fe-rich clays carry the AMS signal. Lastly, an evaluation of the origin of chalcopyrite and monazite is performed through provenance analysis. These minerals are attributed to hydrothermal mineralization however, strong evidence suggests that some fraction of these grains were sourced from the Michigan Peninsula.
High liver fibrosis scores in metabolic dysfunction-associated fatty liver disease patients are associated with adverse atrial remodeling and atrial fibrillation recurrence following catheter ablation
Authors: Decoin Raphaël , Butruille Laura , Defrancq Thomas , Robert Jordan , Destrait Nicolas , Coisne Augustin , Aghezzaf Samy , Woitrain Eloise , Gouda Zouriatou , Schino Sofia , Klein Cédric , Maboudou Patrice , Brigadeau François , Klug Didier , Vincentelli Andre , Dombrowicz David , Staels Bart , Montaigne David , Ninni Sandro 
Published: August 2022

BackgroundA number of epidemiological studies have suggested an association between metabolic dysfunction-associated fatty liver disease (MAFLD) and the incidence of atrial fibrillation (AF). However, the pathogenesis leading to AF in the context of MAFLD remains unclear. We therefore aimed at assessing the impact of MAFLD and liver fibrosis status on left atrium (LA) structure and function.MethodsPatients with a Fatty Liver Index (FLI) &gt;60 and the presence of metabolic comorbidities were classified as MAFLD+. In MAFLD+ patients, liver fibrosis severity was defined using the non-alcoholic fatty liver disease (NAFLD) Fibrosis Score (NFS), as follows: MAFLD w/o fibrosis (NFS ≦ −1.455), MAFLD w/indeterminate fibrosis (−1.455 &lt; NFS &lt; 0.675), and MAFLD w/fibrosis (NFS ≧ 0.675). In the first cohort of patients undergoing AF ablation, the structural and functional impact on LA of MAFLD was assessed by LA strain analysis and endocardial voltage mapping. Histopathological assessment of atrial fibrosis was performed in the second cohort of patients undergoing cardiac surgery. Finally, the impact of MAFLD on AF recurrence following catheter ablation was assessed.ResultsIn the AF ablation cohort (NoMAFLD n = 123; MAFLD w/o fibrosis n = 37; MAFLD indeterm. fibrosis n = 75; MAFLD w/severe fibrosis n = 10), MAFLD patients with high risk of F3–F4 liver fibrosis presented more LA low-voltage areas as compared to patients without MAFLD (16.5 [10.25; 28] vs 5.0 [1; 11] low-voltage areas p = 0.0115), impaired LA reservoir function assessed by peak left atrial longitudinal strain (19.7% ± 8% vs 8.9% ± 0.89% p = 0.0268), and increased LA volume (52.9 ± 11.7 vs 43.5 ± 18.0 ml/m2 p = 0.0168). Accordingly, among the MAFLD patients, those with a high risk of F3–F4 liver fibrosis presented a higher rate of AF recurrence during follow-up (p = 0.0179). In the cardiac surgery cohort (NoMAFLD n = 12; MAFLD w/o fibrosis n = 5; MAFLD w/fibrosis n = 3), an increase in histopathological atrial fibrosis was observed in MAFLD patients with a high risk of F3–F4 liver fibrosis (p = 0.0206 vs NoMAFLD; p = 0.0595 vs MAFLD w/o fibrosis).ConclusionIn conclusion, we found that liver fibrosis scoring in MAFLD patients is associated with adverse atrial remodeling and AF recurrences following catheter ablation. The impact of the management of MAFLD on LA remodeling and AF ablation outcomes should be assessed in dedicated studies.
Getting pregnant with congenital adrenal hyperplasia: Assisted reproduction and pregnancy complications. A systematic review and meta-analysis
Authors: Guo Xiaoyan , Zhang Yu , Yu Yiqi , Zhang Ling , Ullah Kamran , Ji Mengxia , Jin Bihui , Shu Jing 
Published: August 2022

Many patients with congenital adrenal hyperplasia (CAH) refrain from seeking pregnancy, suffer from infertility or worry about pregnancy complications, mainly due to genitalia abnormalities, anovulation, unreceptive endometrium and metabolic disturbances. Despite those challenges, many live births have been reported. In this systematic review, we focused on the key to successful assisted reproduction strategies and the potential pregnancy complications. We did a systematic literature search of Pubmed, Medline and Scopus for articles reporting successful pregnancies in CAH other than 21-hydroxylase deficiency, and found 25 studies reporting 39 pregnancies covering deficiency in steroidogenic acute regulatory protein, 17α-hydroxylase/17,20-lyase, 11β-hydroxylase, P450 oxidoreductase, cytochrome b5 and 3β-hydroxysteroid dehydrogenase. We summarized various clinical manifestations and tailored reproduction strategy for each subtype. Furthermore, a meta-analysis was performed to evaluate the pregnancy complications of CAH patients. A total of 19 cross-sectional or cohort studies involving 1311 pregnancies of classic and non-classic CAH patients were included. Surprisingly, as high as 5.5% (95% CI 2.3%-9.7%) of pregnancies were electively aborted, and the risk was significantly higher in those studies with a larger proportion of classic CAH than those with only non-classical patients (8.43% (4.1%-13.81%) VS 3.75%(1.2%-7.49%)), which called for better family planning. Pooled incidence of miscarriage was 18.2% (13.4%-23.4%) with a relative risk (RR) of 1.86 (1.27-2.72) compared to control. The miscarriage rate in non-classical CAH patients was not significantly different with or without glucocorticoid treatment from retrospective studies. CAH patients were also more susceptible to gestational diabetes mellitus, with a prevalence of 7.3% (2.4%-14.1%) and a RR 2.57 (1.29-5.12). However, risks of preeclampsia, preterm birth and small for gestational age were not significantly different. 67.8% (50.8%-86.9%) CAH patients underwent Cesarean delivery, 3.86 (1.66-8.97) times the risk of the control group. These results showed that fertility is possible for CAH patients but special care was necessary when planning, seeking and during pregnancy.Systematic Review RegistrationPROSPERO https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=342642, CRD42022342642.
Assessing wave energy converters in the gulf of Mexico using a multi-criteria approach
Authors: Diaz-Maya Miqueas , Ulloa Marco , Silva Rodolfo 
Published: August 2022

The wave power in the Gulf of Mexico was analyzed, using 42 years (1979–2020) of simulated data, with ERA-5 winds to force the WAVEWATCH III wave model. The model was successfully validated with three NDBC buoys, 42,055, 42,001 and 42,002. Comparison of significant wave heights obtained from the Jason-2, Cryosat-2, and Saral satellites showed good mean correlation coefficients and root mean squares. The spatial distribution of wave power was studied, as well as its seasonal variability. The region studied has moderate availability of wave power with marked seasonality. A multi-criteria MCA approach, including both sea state and wave energy converters (WECs), was then applied. Nine virtual sites were selected for the study and the AAHPA device gave best results in 7 virtual sites and the Wavestar device in the remaining two. The technology of these two devices, a system of oscillating buoys, is the most viable technology for the Gulf of Mexico.