bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unique Angiogenesis From Cardiac Arterioles During Pericardial Adhesion Formation
Authors: Namiguchi Kenji , Sakaue Tomohisa , Okazaki Mikio , Kanno Kaho , Komoda Yuhei , Shikata Fumiaki , Kurata Mie , Ota Noritaka , Kubota Yoshiaki , Kurobe Hirotsugu , Nishimura Takashi , Masumoto Junya , Higashiyama Shigeki , Izutani Hironori 
Published: February 2022

ObjectivesThe molecular mechanisms underlying post-operative pericardial adhesions remain poorly understood. We aimed to unveil the temporal molecular and cellular mechanisms underlying tissue dynamics during adhesion formation, including inflammation, angiogenesis, and fibrosis.Methods and ResultsWe visualized cell-based tissue dynamics during pericardial adhesion using histological evaluations. To determine the molecular mechanism, RNA-seq was performed. Chemical inhibitors were administered to confirm the molecular mechanism underlying adhesion formation. A high degree of adhesion formation was observed during the stages in which collagen production was promoted. Histological analyses showed that arterioles excessively sprouted from pericardial tissues after the accumulation of neutrophils on the heart surface in mice as well as humans. The combination of RNA-seq and histological analyses revealed that hyperproliferative endothelial and smooth muscle cells with dedifferentiation appeared in cytokine-exposed sprouting vessels and adhesion tissue but not in quiescent vessels in the heart. SMAD2/3 and ERK activation was observed in sprouting vessels. The simultaneous abrogation of PI3K/ERK or TGF-β/MMP9 signaling significantly decreased angiogenic sprouting, followed by inhibition of adhesion formation. Depleting MMP9-positive neutrophils shortened mice survival and decreased angiogenic sprouting and fibrosis in the adhesion. Our data suggest that TGF-β/matrix metalloproteinase-dependent tissue remodeling and PI3K/ERK signaling activation might contribute to unique angiogenesis with dedifferentiation of vascular smooth muscle cells from the contractile to the synthetic phenotype for fibrosis in the pericardial cavity.ConclusionsOur findings provide new insights in developing prevention strategies for pericardial adhesions by targeting the recruitment of vascular cells from heart tissues.
Sexual Health Dysfunction After Radiotherapy for Gynecological Cancer: Role of Physical Rehabilitation Including Pelvic Floor Muscle Training
Authors: Barcellini Amelia , Dominoni Mattia , Dal Mas Francesca , Biancuzzi Helena , Venturini Sara Carla , Gardella Barbara , Orlandi Ester , Bø Kari 
Published: February 2022

IntroductionThe present study aims to describe: 1. How the side effects of radiotherapy (RT) could impact sexual health in women; 2. The effectiveness of physical rehabilitation including pelvic floor muscle training (PFMT) in the management of sexual dysfunction after RT.Materials and MethodsSearch keys on PubMed, Web of Science, Scopus, PEDro, and Cochrane were used to identify studies on women treated with radical or adjuvant RT and/or brachytherapy for gynecological cancers with an emphasis on vulvo-vaginal toxicities and PFMT studies on sexual dysfunction for this group of women.ResultsRegarding the first key question, we analyzed 19 studies including a total of 2,739 women who reported vaginal dryness, stenosis, and pain as the most common side effects. Reports of dosimetric risk factors and dose-effect data for vaginal and vulvar post-RT toxicities are scant. Only five studies, including three randomized controlled trials (RCTs), were found to report the effect of PFMT alone or in combination with other treatments. The results showed some evidence for the effect of training modalities including PFMT, but to date, there is insufficient evidence from high-quality studies to draw any conclusion of a possible effect.ConclusionsGynecological toxicities after RT are common, and their management is challenging. The few data available for a rehabilitative approach on post-actinic vulvo-vaginal side effects are encouraging. Large and well-designed RCTs with the long-term follow-up that investigate the effect of PFMT on vulvo-vaginal tissues and pelvic floor muscle function are needed to provide further guidance for clinical management.
Three Month Follow-Up of Patients With COVID-19 Pneumonia Complicated by Pulmonary Embolism
Authors: Calabrese Cecilia , Annunziata Anna , Flora Martina , Mariniello Domenica Francesca , Allocca Valentino , Palma Maria Ilaria , Coppola Antonietta , Meoli Ilernando , Pafundi Pia Clara , Fiorentino Giuseppe 
Published: February 2022

Background: Previous studies have demonstrated persistent dyspnoea and impairment of respiratory function in the follow-up of patients who have recovered from COVID-19 pneumonia. However, no studies have evaluated the clinical and functional consequences of COVID-19 pneumonia complicated by pulmonary embolism.Objective: The aim of our study was to assess the pulmonary function and exercise capacity in COVID-19 patients 3 months after recovery from pneumonia, either complicated or not by pulmonary embolism.Methods: This was a retrospective, single-centre, observational study involving 68 adult COVID-19 patients with a positive/negative clinical history of pulmonary embolism (PE) as a complication of COVID-19 pneumonia. Three months after recovery all patients underwent spirometry, diffusion capacity of the lungs for carbon monoxide (DLCO), and 6 minute walk test (6MWT). In addition, high-resolution computed tomography (HRCT) of the lung was carried out and CT-pulmonary angiography was conducted only in the PE+ subgroup. Patients with a previous diagnosis of PE or chronic lung diseases were excluded from the study.Results: Of the 68 patients included in the study, 24 had previous PE (PE+) and 44 did not (PE−). In comparison with the PE− subgroup, PE+ patients displayed a FVC% predicted significantly lower (87.71 ± 15.40 vs 98.7 ± 16.7, p = 0.009) and a significantly lower DLCO% predicted (p = 0.023). In addition, a higher percentage of patients were dyspnoeic on exercise, as documented by a mMRC score ≥1 (75% vs 54.3%, p &lt; 0.001) and displayed a SpO2 &lt;90% during 6MWT (37.5% vs 0%, p &lt; 0.001). HRCT features suggestive of COVID-19 pneumonia resolution phase were present in both PE+ and PE− subjects without any significant difference (p = 0.24) and abnormalities at CT pulmonary angiography were detected in 57% of the PE+ subgroup.Conclusion: At the 3 month follow-up, the patients who recovered from COVID-19 pneumonia complicated by PE showed more dyspnoea and higher impairment of pulmonary function tests compared with those without PE.
Susceptibility to Metabolic Diseases in COVID-19: To be or Not to be an Issue
Authors: Kaviani Maryam , Keshtkar Somayeh , Soleimanian Saeede , Sabet Sarvestani Fatemeh , Azarpira Negar , Pakbaz Sara 
Published: February 2022

Despite the passage of more than 17 months from the beginning of the COVID-19 pandemic, challenges regarding the disease and its related complications still continue in recovered patients. Thus, various studies are underway to assay the long-term effects of COVID-19. Some patients, especially those with severe symptoms, experience susceptibility to a range of diseases and substantial organ dysfunction after recovery. Although COVID-19 primarily affects the lungs, multiple reports exist on the effect of this infection on the kidneys, cardiovascular system, and gastrointestinal tract. Studies have also indicated the increased risk of severe COVID-19 in patients with diabetes. On the other hand, COVID-19 may predispose patients to diabetes, as the most common metabolic disease. Recent studies have shown that Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) binds to Angiotensin-Converting Enzyme 2 (ACE2) receptors, which are expressed in the tissues and organs involved in regulating the metabolic status including pancreas, adipose tissue, gastrointestinal tract, and kidneys. Therefore, SARS-CoV-2 may result in metabolic disturbance. However, there are still many unknowns about SARS-CoV-2, which are required to be explored in basic studies. In this context, special attention to molecular pathways is warranted for understanding the pathogenesis of the disease and achieving therapeutic opportunities. Hence, the present review aims to focus on the molecular mechanisms associated with the susceptibility to metabolic diseases amongst patients recovered from COVID-19.
Food Supply Chain Safety Research Trends From 1997 to 2020: A Bibliometric Analysis
Authors: Luo Jianli , Leng Shujuan , Bai Yanhu 
Published: February 2022

BackgroundThe COVID-19 pandemic has exposed the fragility of the global food supply chain, strengthened consumers' awareness of the traceability system throughout the supply chain, and gradually changed consumers' consumption concepts and consumption patterns. Therefore, the aim of this study was to analyse the relevant literature on food safety in the food supply chain, examine its current status, hot spots, and development trends, and provide some suggestions for academics and relevant government departments in food supply chain safety research.MethodsWe collected the literature on the food safety research of the food supply chain from the Scopus database, used BibExcel to count the subject categories, published journals, geographical distributions, research institutions, authors, and keywords in the literature, and used Pajek software to analyse the keywords in the literature, perform co-occurrence analysis, draw related knowledge maps, and perform cluster analysis on primary keywords. Finally, to study the development trend, we used CorTexT software to illustrate the theme evolution path map in this research field.ResultsThe keyword visualization network revealed the following key research topics: (1) food safety at the consumer end of the food supply chain, (2) food safety management in the food supply chain, (3) risk management of food safety in the food safety chain, and (4) food safety at the production end of the food supply chain.ConclusionsAfter comprehensive discussion and analysis, we concluded that food supply chain management may be a hot topic in the future, especially in traceability management combined with the blockchain. It is necessary to explore in-depth how the blockchain can affect the food supply chain to provide a theoretical basis for managing the latter.
Preventing Violence by Teachers in Primary Schools: Study Protocol for a Cluster Randomized Controlled Trial in Haiti
Authors: López García Ana Isabel , Scharpf Florian , Hoeffler Anke , Hecker Tobias 
Published: February 2022

ContextAlthough teacher violence at schools is a serious problem in Haiti, there is a lack of systematic evidence on the effectiveness of school-based interventions in reducing teacher violence in this low-income country.ObjectiveTo test the effectiveness of the preventative intervention Interaction Competencies with Children for Teachers (ICC-T) aiming to reduce teachers' use of violent disciplinary strategies and to improve their interaction competences with children in the Haitian context.Design, Setting, ParticipantsThe study is designed as a two-arm matched cluster randomized controlled trial. The sample consists of 468 teachers and 1,008 children from 36 (community and public) primary schools around Cap-Haïtien (Département du Nord) in Haiti. Data will be collected in three phases, before the intervention, and 6 and 18 months after.InterventionIn the group of intervention schools, ICC-T will be delivered as a 5-day training workshop. Workshop sessions are divided into five modules: 1) improving teacher-student interactions, 2) maltreatment prevention, 3) effective discipline strategies, 4) identifying and supporting burdened students, and 5) implementation in everyday school life.Main Outcome MeasureThe main outcome measure is teacher violence assessed in two ways: (i) teachers' self-reported use of violence, and (ii) children's self-reported experiences of violence by teachers.ConclusionsPrior evaluations of ICC-T had been conducted in sub-Saharan Africa with promising results. This study will test for the first time the effectiveness of this intervention outside the context of sub-Saharan Africa.
Parametric Study of Magnetosheath Jets in 2D Local Hybrid Simulations
Authors: Tinoco-Arenas Arturo , Kajdič Primož , Preisser Luis , Blanco-Cano Xóchitl , Trotta Domenico , Burgess David 
Published: February 2022

We perform 2D local hybrid simulations of collisionless shocks in order to study the properties of simulated magnetosheath jets as a function of shock properties, namely their Alfvénic Mach number (MA) and geometry (angle between the upstream magnetic field and the shock normal, θBN). In total we perform 15 simulations with inflow speeds of Vin = 3.3 CA (Alfvén velocity), 4.5 CA and 5.5 CA and θBN = 15°, 30°, 45°, 50°, and 65°. Under these conditions, the shock MA varied between 4.28 and 7.42. In order to identify magnetosheath jets in the simulation outputs, we use four different criteria, equivalent to those utilized to identify subsets of magnetosheath jets, called high-speed jets (Plaschke and Hietala and Angelopoulos, Ann. Geophys., 2013, 31, 1877–1889), transient flux enhancements (Němeček et al., Geophys. Res. Lett., 1998, 25, 1273–1276), density plasmoids (Karlsson et al., J. Geophys. Res., 2012, 117, a–n; Karlsson et al., J. Geophys. Res., 2015, 120, 7390–7403) and high-speed plasmoids (Gunell et al., Ann. Geophys., 2014, 32, 991–1009). In our simulations, the density plasmoids were produced only by shocks with MA ≥5.7, while the high-speed plasmoids only formed downstream of shocks with MA ≥6.97. We show that higher MA shocks tend to produce faster jets that tend to have larger surface area, mass, linear momentum and kinetic energy, while these quantities tend to be anticorrelated with θBN. In general, the increase of θBN to up to 45° results in increased jet formation rates. In the case of high-speed jets in runs with Vin = 3.3 CA and high-speed plasmoids, the jet formation anticorrelates with θBN. The jet production all but ceases for θBN = 65° regardless of the shock’s MA. The maximum distances of the magnetosheath jets from the shocks were ≲140 di (upstream ion intertial lengths), which, estimating 1 di ∼100–150 km at Earth, corresponds to 2.4–3.3 Earth radii. Thus, none of the simulated jets reached distances equivalent to the average extension of the Earth’s subsolar magnetosheath, which would make them the equivalents of geoeffective jets. Higher MA shocks are probably needed in order to produce such jets.
A Novel Multi-Port Containment System for Laparoscopic Power Morcellation to Prevent Tumoral Spread: A Retrospective Cohort Study
Authors: Wang Wenhui , Liang Haiyan , Zhao Fang , Yu Huan , Rong Chunhong , Feng Weiwei , Chen Qingyun , Yang Yanjun , Li Qian , Feng Dingqing , Dong Yuxiao , Xue Ming , Liang Jing , Ling Bin 
Published: February 2022

ObjectiveTo report a novel multi-port containment (NMC) system for laparoscopic power morcellation to prevent tumoral spread and to evaluate its safety, validity, and feasibility.MethodsThis retrospective study included women who underwent laparoscopic myomectomy (LM) between January 2014 and August 2020 at a single academic institution. The NMC system was used in the study group (n = 193); the control group underwent unprotected LM (n = 1753).ResultsAfter 1:1 propensity score matching, no significant differences in the baseline characteristics were observed between 193 matched pairs. Bag damages were detected in two cases in the study group before morcellation, and the NMC systems were replaced. There were no significant differences between the two groups in terms of the complications, total operative time, estimated blood loss, or postoperative hospitalization duration. In the study group, all operations were completed and no system rupture or leakage was observed. The median follow-up times were 21 and 54 months in the study and control groups, respectively. There was no peritoneal tissue spread in the study group. However, three (3/5, 0.6%) and six (6/1,753, 0.3%) patients in the control group experienced malignant and benign peritoneal tissue spread, respectively.ConclusionThe NMC system for laparoscopic power morcellation is valid, safe, and feasible for preventing a tumor spread.
Pour un atlas historique des agricultures précontemporaines en France
Authors: Sigaut François 
Published: February 2022

Towards an atlas of French agricultures in the past, François Sigaut
One of the difficulties of current rural history stems from the sheer accumulation of information, the sum of which overcomes the expressive possibilities of the literary narrative, even when one takes into account the help provided by computers. One possible solution, hardly new in itself, but rather neglected so far, can be found in the more systematic use of cartography, since the latter is a tool for analysis as well as for synthesis. Mapping has the long-since recognized advantages of brevity and density of information. Above all, maps necessarily imply a rigorous methodology in the collection and setting out of data ; such precision is often enough to bring about novel results from data heretofore considered as having been already explored, but actually only superficially surveyed.
The proposal for an atlas which is outlined in this paper is one of several possible ways to increase the use of cartography. This proposal includes a review of several examples of this kind already published, and lists themes making possible the publication of such a work within a relatively short period of time (the concept of fallow land, the statistics of donkeys, the double contrast village /hamlet and town/ village, etc.).
L'évolution électorale des campagnes de la Bourgogne du Sud (1848-1995)
Authors: Lévêque Pierre 
Published: February 2022

En Saône-et-Loire, département «patriote » lors de la Révolution, les ruraux ont opté pour les «Montagnards » en 1848-1850. Après l'épisode bonapartiste, ils ont voté en majorité pour les républicains, puis pour les radicaux à partir de 1885, enfin pour la SFIO dans l'entre-deux-guerres. Petits exploitants et artisans ruraux se reconnaissaient dans une gauche laïque et réformatrice. La droite n'était toutefois nulle part absente, et conservait quelques places fortes comme le Brionnais.
L'effondrement de la SFIO de 1945 à 1958 a fait basculer les campagnes à droite, malgré les progrès temporaires du PC. Par la suite, le changement social, et notamment la quasi-disparition du groupe des petits paysans, ont accéléré le déclin du communisme, fragilisé la remontée du parti socialiste, fait perdre à la gauche son bastion mâconnais et consolidé - sauf exceptions localisées - la prédominance de la droite.
La mainmorte dans la France du XVIIIe siècle. Le cas des provinces du Centre
Authors: Bressan Thierry 
Published: February 2022

Mortmain in XVIIIth-century France: the case of the Centre region.
In eighteenth-century France, the mortmain regimens left over from medieval serfdom still concerned a large territory, particularly most of the central, eastern and north-eastern regions. They took various forms («personal», «real» or «mixed mortmain») and reached various degrees. For instance, some of them reduced to serfdom only the tenure and not the tenant farmer. Most of the provinces of the Centre region (Blésois, Touraine, Berry, Marche, Auvergne, Bourbonnais, and Nivernais) held a particularly important position within this area. These provinces were characterized by strong, often complex customary rules on this topic, and their weight was quantitatively significant ; this latter characteristic was only partially modified after Necker's August 1779 edict. Nevertheless, in spite of these undeniably attractive elements, the study of their servile regimens, for the most part pure regimens of «real mortmain», has been particularly neglected up until now.
Essai d’archéologie horticole en banlieue parisienne. Saint-Denis et Rueil-Malmaison (XIVe-XIXc siècle)
Authors: Dufour Jean-Yves 
Published: February 2022

Late medieval and moderne horticulture in the suburbs of Paris, Saint-Denis et Rueil-Malmaison from XIVth to XIXth century.
Using archaeological remains found in the suburbs of Paris, we discuss the ways of planting used in fruit arboriculture since the Late Middle Ages. Field results are compared to techniques proposed in contemporary books on agronomy, and replaced within the framework of regional history. Orchards, vineyards and some vegetable gardening (such as asparagus-growing) left traces on the ground, which we try to interpret. Key interpretive elements in our approach to cultivated species include soil components, techniques used (ridge, ditch, or espalier planting), exposure to the sun, and local history.
Approches bioarchéologiques de l’habitat castral languedocien. Huit sites de la bordure méridionale du Massif central (Xe-XVIe siècle)
Authors: Durand Aline , Forest Vianney , Gardeisen Armelle , Ruas Marie-Pierre 
Published: February 2022

Bioarcheobgical approaches of castrum settlements in Languedoc. A case study of the Southern edge of Massif central (c. 900-c. 1600)
In this paper, we try to develop a bioarcheological approach of the castrum settlements in a Mediterranean medium mountain habitat, through the simultaneous application of three different disciplinary fields, anthracology, archeozoology, and carpology, in order to bring to the fore, if possible, the specificities of the moutain castrum compared to the castrum populatum of the plains. Thus, it turns out that the castles built during the first age of the castrum era were focussing on consumption and the exploitation of their environment rather than on production. The gamut of agricultural and pastoral activities one can observe was enlarged during the XIIth and XIIIth centuries, and during their period of maturity the mountain castra eventually developped a system of ager/sal-tus/silva.
But this phase of maximum development of the castra was also one of regional différenciation. Indeed, the expression of local particularism was promoted by the com-partimentalized relief of Languedoc. The micro-region of Calberte in Lozère was hardly identical to the micro-region of Castlar de Durfort at the western tip of the Montagne noire. Economic activities were characterized by their polyvalency, and this indeed was one of the major differences between castrum settlements of medium mountain and large fortified villages in the plain.
Le métayage au Mexique (XVIe-XXe siècle)
Authors: Colin Jean-Philippe 
Published: February 2022

Les chroniques espagnoles du XVIe siècle montrent que la société aztèque connaissait de véritables relations de tenure, que l’on peut distinguer du prélèvement du tribut. Par la suite, le métayage s’intégre dans le cadre du «système-hacienda», sous des conditions et avec une importance variables selon le contexte économique et démographique du moment. Dans l’optique des haciendas, la logique du métayage, comme mode de faire-valoir alternatif au faire-valoir direct et à la location, est à rechercher dans les défaillances du marché du travail, les contraintes de financement, la faible rentabilité et/ou le risque d’une production en faire-valoir direct. Face à une hacienda en situation d’accaparement foncier, le métayer est, de fait, un pseudo-/péon.
La Réforme agraire, en redistribuant les cartes du jeu foncier, conduit à un change¬ ment radical de perspective. L’attributaire d’une dotation foncière se retrouve parfois sans moyens suffisants pour la mettre en valeur et la cède en tout ou partie en faire-valoir indirect. La relation entre propriétaire et métayer tend alors parfois à s’inverser, lorsque le métayer est en position économique nettement plus favorable que le propriétaire mini-fundiste. Le plus souvent cependant cette relation s’équilibre, le métayage s’établissant entre des acteurs qui se trouvent tous deux sous contraintes (en particulier de trésorerie) et mettent en commun leurs ressources productives complémentaires dans une logique de partenariat.