bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating Tumor DNA Characteristics Based on Next Generation Sequencing and Its Correlation With Clinical Parameters in Patients With Lymphoma
Authors: Wu Xiao-Bo , Hou Shu-Ling , Zhang Qiao-Hua , Jia Ning , Hou Min , Shui Wen 
Published: July 2022

BackgroundLymphoma is a heterogeneous group of tumors in terms of morphological subtypes, molecular alterations, and management. However, data on circulating tumor DNA (ctDNA) mutated genes are limited. The purpose of this study was to investigate the features of the ctDNA mutated genes, the prognosis, and the association between the ctDNA mutated genes and the clinical parameters in lymphoma.MethodsDifferences in the ctDNA between the mutated genes and the prognosis of 59 patients with Hodgkin’s lymphoma (HL) (10.2%), germinal center B-cell–like lymphoma (GCB) (28.8%), nongerminal center B-cell–like lymphoma (non-GCB) (50.8%), and marginal zone lymphoma (MZL) (10.2%) were analyzed by next generation sequencing (NGS) targeting 121 lymphoma-relevant genes.ResultsGenetic alterations were identified in the ctDNA samples with a median of 6 variants per sample. The genetic variation of the ctDNA in the plasma was found to be significantly correlated with the clinical indices in lymphoma. The genetic heterogeneity of different lymphoma subtypes was clearly observed in the ctDNAs from HL, GCB, non-GCB, and MZL, confirming that distinct molecular mechanisms are involved in the pathogenesis of different lymphomas.ConclusionOur findings suggest that NGS-based ctDNA mutation analysis reveals genetic heterogeneity across lymphoma subtypes, with potential implications for discovering therapeutic targets, exploring genomic evolution, and developing risk-adaptive therapies.
Evaluation of the Efficiency of MRI-Based Radiomics Classifiers in the Diagnosis of Prostate Lesions
Authors: Li Linghao , Gu Lili , Kang Bin , Yang Jiaojiao , Wu Ying , Liu Hao , Lai Shasha , Wu Xueting , Jiang Jian 
Published: July 2022

ObjectiveTo compare the performance of different imaging classifiers in the prospective diagnosis of prostate diseases based on multiparameter MRI.MethodsA total of 238 patients with pathological outcomes were enrolled from September 2019 to July 2021, including 142 in the training set and 96 in the test set. After the regions of interest were manually segmented, decision tree (DT), Gaussian naive Bayes (GNB), XGBoost, logistic regression, random forest (RF) and support vector machine classifier (SVC) models were established on the training set and tested on the independent test set. The prospective diagnostic performance of each classifier was compared by using the AUC, F1-score and Brier score.ResultsIn the patient-based data set, the top three classifiers of combined sequences in terms of the AUC were logistic regression (0.865), RF (0.862), and DT (0.852); RF “was significantly different from the other two classifiers (P =0.022, P =0.005), while logistic regression and DT had no statistical significance (P =0.802). In the lesions-based data set, the top three classifiers of combined sequences in terms of the AUC were RF (0.931), logistic regression (0.922) and GNB (0.922). These three classifiers were significantly different from.ConclusionThe results of this experiment show that radiomics has a high diagnostic efficiency for prostate lesions. The RF classifier generally performed better overall than the other classifiers in the experiment. The XGBoost and logistic regression models also had high classification value in the lesions-based data set.
The Effect of Statins on Clinical Outcome Among Hospitalized Patients With COVID-19: A Multi-Centric Cohort Study
Authors: Umakanthan Srikanth , Senthil Sanjum , John Stanley , Madhavan Mahesh K. , Das Jessica , Patil Sonal , Rameshwaram Raghunath , Cintham Ananya , Subramaniam Venkatesh , Yogi Madhusudan , Bansal Abhishek , Achutham Sumesh , Shekar Chandini , Murthy Vijay , Selvaraj Robbin 
Published: July 2022

The coronavirus disease-2019 (COVID-19) is caused by SARS-CoV-2, leading to acute respiratory distress syndrome (ARDS), thrombotic complications, and myocardial injury. Statins, prescribed for lipid reduction, have anti-inflammatory, anti-thrombotic, and immunomodulatory properties and are associated with reduced mortality rates in COVID-19 patients. Our goal was to investigate the beneficial effects of statins in hospitalized COVID-19 patients admitted to three multi-specialty hospitals in India from 1 June 2020, to 30 April 2021. This retrospective study included 1,626 patients, of which 524 (32.2%) were antecedent statin users among 768 patients (384 statin users, 384 non-statin users) identified with 1:1 propensity-score matching. We established a multivariable logistic regression model to identify the patients’ demographics and adjust the baseline clinical and laboratory characteristics and co-morbidities. Statin users showed a lower mean of white blood cell count (7.6 × 103/µL vs. 8.1 × 103/µL, p &lt; 0.01), and C-reactive protein (100 mg/L vs. 120.7 mg/L, p &lt; 0.001) compared to non-statin COVID-19 patients. The same positive results followed in lipid profiles for patients on statins. Cox proportional-hazards regression models evaluated the association between statin use and mortality rate. The primary endpoint involved mortality during the hospital stay. Statin use was associated with lower odds of mortality in the propensity-matched cohort (OR 0.52, 95% CI 0.33-0.64, p &lt; 0.001). These results support the previous evidence of the beneficial effects of statins in reducing mortality in hospitalized COVID-19 patients.
Research on the Nonlinear Absorption Coefficient of 98% Deuterated DKDP Crystal at Fourth-Harmonic-Generation Wavelength
Authors: Wu Pengcheng , Zhang Lisong , Xu Mingxia , Liu Baoan , Wei Liening , Li Yang , Chai Xiangxu , Sun Xun 
Published: July 2022

A series of 98% deuterated DKDP crystals were grown in solutions with different pD values (2.9, 3.3, 3.8, and 4.3) using the rapid growth method. Samples were cut along the z-direction and fourth-harmonic-generation (FHG) direction which contained both pyramidal and prismatic regions. The nonlinear absorption (NLA) coefficient β of 98% deuterated DKDP crystals was obtained using the Z-scan method operated at the FHG wavelength (266 nm) of a picosecond Nd:YAG laser. According to the results, the nonlinear absorption at 266 nm could be identified as two-photon absorption. The β values of crystal grown in the solution with 3.3 pD value were higher than those of crystals grown in solutions with other pD values under higher laser fluence. The results also indicated that FHG device samples should be prepared from the pyramidal region due to its lower β value. This work will help optimizing the application of 98% DKDP crystals as FHG elements in high-power laser systems.
Spatial-Temporal Distribution of Allelopathic Rice Roots in Paddy Soil and Its Impact on Weed-Suppressive Activity at the Seedling Stages
Authors: Li Jiayu , Lin Shunxian , Ma Huayan , Wang Yanping , He Haibin , Fang Changxun 
Published: July 2022

BackgroundAllelochemicals secreted by allelopathic rice roots are transmitted to the receptor rhizosphere through the soil medium to inhibit the growth of the surrounding weeds. This research aimed to explore the relationships between the spatial-temporal distribution of rice roots in soil and weed-suppression ability at its seedling stage.ResultsThis study first examined the root distribution of three rice cultivars in paddy soil in both vertical and horizontal directions at 3–6 leaf stage. Then, an experiment using rice–barnyardgrass mixed culture was conducted to analyze the allelopathic potential and allelochemical content secreted by rice roots in different lateral soil layers. The results showed that allelopathic rice had a smaller root diameter and larger root length density, root surface area density, and root dry weight density than those of non-allelopathic rice, in the top 5 cm at 5- and 6-leaf stages. In particular, there were significant differences in root distribution at the horizontal distance of 6–12 cm. Besides, allelopathic rice significantly inhibited the above-ground growth of barnyardgrass co-cultured at 12 cm lateral distance in situ, and the content of benzoic acid derivatives in allelopathic rice in a 6–12 cm soil circle was higher than that observed at 0–6 cm distance. Moreover, correlation analysis confirmed that the distribution of roots in the horizontal distance was significantly correlated with weed inhibition effect and allelochemical content.ConclusionThese results implied that spatial distribution of allelopathic rice roots in paddy soil, particularly at the lateral distance, appears to have important impact on its weed-suppressive activity at the seedling stage, suggesting that modifying root distribution in soil may be a novel method to strengthen the ability of rice seedlings to resist paddy weeds.
Purpose in Life and Character Strengths as Predictors of Health Sciences Students’ Psychopathology During the COVID-19 Pandemic
Authors: Echeverria Iván , Peraire Marc , Penadés Danaide , Quintero Valentina , Benito Ana , Almodóvar Isabel , Haro Gonzalo 
Published: July 2022

BackgroundHealth sciences students experience high levels of psychopathology conditioned by psychosocial, financial, and academic factors. However, COVID-19 pandemic might even have worsened their mental health. Thus, this article aims to evaluate how the exposure to COVID-19 pandemic has affected these students’ mental health and to determine the effect of purpose in life and character strengths on this psychopathology.MethodsA cross-sectional study of unpaired samples was carried out in Spain during the first and third waves of the pandemic in 70 medical and 52 nursing students.ResultsThe risk factor that most determined the appearance of anxiety was the exposure of family and friends to COVID-19 (OR = 4.01; p &lt; 0.001), while the most protective factors were honesty (OR = –1.14; p = 0.025) and purpose in life (OR = –0.18; p &lt; 0.001). Purpose in life also protected against the onset of depression and total psychopathology. In addition, we observed studying medicine was a protective factor against total psychopathology while being a nursing student was associated with high levels of acute stress.ConclusionExposure of the students’ family and friends to SARS-CoV-2 favored the appearance of symptoms of anxiety. Honesty had a preventing role in the onset of anxiety and a high purpose in life was protective against the appearance of anxiety, depression, and total psychopathology.
Social Media Disorder, Mental Health, and Validation of the Chinese Version of 27-Item Social Media Disorder Scale in Chinese College Students
Authors: Lei Hui , Huang Yaqing , Chai Ya , Zhang Xiaocui 
Published: July 2022

ObjectiveWith the widespread use of social media, excessive use of social media may lead to problematic behaviors such as social media disorder, which has a negative impact on teenagers' mental health. Thus, it is an urgent need to provide a measurement tool to assess social media addiction in different cultures. The aim of this study was to assess the psychometric properties of the Chinese version of 27-item Social Media Disorder (SMD) Scale (developed using the diagnostic criteria of DSM-V Internet Gaming Disorder) in college students, and to verify its impact on mental health.MethodsTwo online surveys were conducted among a total of 1,539 Chinese college students, including 1,316 subjects in sample 1 and 223 subjects in sample 2. The discrimination, criterion validity, construct validity and reliability of the Chinese version of SMD-27 scale were examined.ResultsThe Chinese version of SMD-27 scale showed excellent psychometric properties. The item-total correlation coefficients of the scale ranged from 0.31 to 0.56, and the item-dimension correlations of the scale ranged from 0.459 to 0.834. Findings from confirmatory factor analysis indicated a great fit of the model of the Chinese version of SMD-27, with CFI = 0.956, TLI = 0.951, RMSEA = 0.036 in sample one and CFI = 0.970, TLI = 0.967, RMSEA = 0.040 in sample two, thus confirming the second-order factor structure of the scale. The SMD-27 scale showed good internal consistency between two different samples with their respective Cronbach's alpha of 0.87 and 0.92, and good test-retest reliability over a period of 1 month. In addition, multiple regression results generally supported the impact of social media addiction on mental health.ConclusionThis study provides evidence that the Chinese version of SMD-27 scale is applicable to Chinese college populations, and it is a promising tool for the study of social media addiction in China.
Censo dos cursos de graduação em enfermagem brasileiros, públicos e privados / Census of undergraduate nursing courses in Brazil, public and private
Authors: Pinto Anaísa Cristina , Barros Sônia , Floriano Lara Simone Messias , França Thiago Eduardo de , Camarini Aida di Lincoln Iglesias , Silva Letícia Marques 
Published: July 2022

Objetivo: Realizar um censo dos cursos de graduação em Enfermagem em instituições de Ensino Superior brasileiras, segundo categoria administrativa pública e privada. Método: Estudo de abordagem quantitativa, de base documental, do tipo analítico-descritivo, que utilizou dados sobre os Cursos de Enfermagem brasileiros do portal e-MEC e das páginas destes e nos sites das Instituições de Ensino Superior. Resultados: A maioria das universidades e dos Cursos de Enfermagem brasileiros são privados. Observa-se que, ao final da segunda década dos anos 2000 a tendência de expansão do setor privado na educação continua e, a mitigação do público toma destaque. Conclusões: Entende-se que educação, ciência e tecnologia são eixos prioritários de desenvolvimento de um país. E, mesmo que a agenda governamental não coloque os setores na posição de destaque que merecem, verifica-se a continuidade de dedicação nestes temas.
Um estudo de caso sobre os agrupamentos de gêneros e relações intergenéricas em: Reinações de Narizinho de Monteiro Lobato e nas narrativas da tradição oral / A case study on genre groupings and intergeneric relations in: reinações de narizinho by monteiro lobato and in oral tradition narratives
Authors: Araújo Nádia Barros , Das Neves Alexandrina Verônica Guedes , Ferraz Rinalda Cordeiro Siqueira Costa 
Published: July 2022

Neste artigo propõe-se uma análise da obra Reinações De Narizinho de Monteiro Lobato (2009) e das narrativas orais dos contadores tradicionais de histórias, tomando como percurso teórico-metodológico os agrupamentos e relações entre os gêneros textuais/discursivos, sob a metáfora de “constelações de gêneros” e as relações intergenéricas. Para tanto, empreende-se uma análise dos argumentos de gêneros propostas por Araújo (2021), Marcuschi (2008) e Bezerra (2017), sendo que o primeiro define constelação de gêneros a partir de três eixos temáticos: as características comuns ao ambiente ou à esfera de comunicação; as características de sua constituição genética/o processo formativo; e os propósitos comunicativos pelos quais os gêneros são reconhecidos por seus usuários; o segundo define as relações inter-gêneros de forma imbricada, os quais se interpenetram para constituírem novos gêneros, para o terceiro os gêneros se manifestam em uma relação dinâmica surgindo dessas relações cadeias, colônias, sistemas, redes, etc. Evidenciou-se, por meio das análises às obras citadas, a presença das relações intergêneros, uma vez que, nas malhas discursivas apresenta-se um conjunto distintivo de gêneros textuais/discursivos que se enlaçam por meio de características que ora os aproximamora os distanciam.
Variação dimensional em peças plásticas automotivas injetadas em diferentes polímeros por processo de injeção convencional / Dimensional variation in automotive plastic parts injected in different polymers by conventional injection process
Authors: Lazareti Clodoaldo , Barboza Robson Fernandes 
Published: July 2022

O objetivo desse trabalho é identificar, a partir de dados técnicos, o tipo de curva estatística de peças injetadas por injeção convencional onde, sendo uma curva de Gauss, diz-se-á que o processo está sob controle estatístico. Esse trabalho tem ainda o objetivo de listar os maiores contribuintes que geram variação dimensional em peças plásticas vs. algumas sugestões quanto a como eliminar ou reduzir tais contribuintes. A metodologia desse trabalho está fundamentada no estudo de cada uma das fontes de variação de processos de injeção de peças plásticas do setor automotivo, experiências vivenciadas na área fabril, fornecedores automotivos, ferramentarias, livros relacionados a moldes, processos de injeção, design, livros de estatística, Manual de Controle Estatístico do Processo (AIAG), entre outros. Esse trabalho abrange o Planejamento Avançado da Qualidade do Produto (APQP) nas fases de elaboração e definição de processos relacionados a injeção de peças plásticas por injeção convencional. Termina-se analisando os resultados através de medições de peças injetadas. Esse exercício permitiu entender o comportamento estatístico de algumas peças automotivas, permitindo-nos julgar que, para esses casos analisados, foi possível obter previsão estatística, pois o pValue foi maior que 0,05. Conclui-se então que se a variação é pequena entre os valores de um grupo de peças (pValue < 0,05), não é correto aplicar os conceitos de CEP, então a recomendação é que seja utilizada uma carta de tendências ou uma carta semáforo, com regiões verde, amarela e vermelha. É importante salientar que a definição das tolerâncias sobre as regiões verde, amarela e vermelha dependem de cada produto.
Síndrome do Quebra-Nozes (“nutcracker”): abordagem multiprofissional / Nutscracker Syndrome (“nutcracker”): multidisciplinary approach
Authors: Cruz Raul Braga de Almeida , Dias Bruno Hállan Meneses , Gonçalves Nathálya de Souza , Silveira Mayara Rios Camardella da , Sampaio Abner Moreira , Júnior Alexandre Sabóia Leitão , Oliveira Ricardo Reges Maia de 
Published: July 2022

A síndrome de quebra-nozes também conhecida como nutcracker, é uma variação anatômica caracterizada pela compressão da veia renal esquerda, entre a aorta abdominal e a artéria mesentérica superior, resultando no refluxo dessa veia e das veias gonadais esquerda VGE. Objetivou-se, apresentar abordagem multiprofissional aplicada a uma paciente diagnósticada com síndrome do quebra-nozes Trata-se de relato de caso, de uma paciante diagnosticada com síndrome de quebra-nozes residente na capital do estado do Ceará. A paciente buscou assistência médica relatando dor suprapúbica e em flanco esquerdo associado a hematúria e infecção do trato urinário. Foi submetida aos exames de imagem, onde necessitou de avaliação médica especializada, sendo diagnosticada com síndrome de quebra-nozes. O quadro de dor persistente se resolveu mediante a nefrectomia esquerda. Portanto, percebeu-se que a síndrome de quebra-nozes impactou negativamente na qualidade de vida da paciente em estudo, fazendo necessário de uma assistência multiprofissional imediata, resolutiva e sobretudo, de qualidade.
Usando o planejamento de experimentos para a predição da temperatura de usinagem através da técnica do termopar acoplado à ferramenta de corte / Using design of experiments for machining temperature prediction by thermocouple inserted in the cutting tool technique
Authors: David Johnnatan Pessoa Carpanez , Pagotto Carlos Renato , Marcomini Raphael Fortes 
Published: July 2022

O presente trabalho visou testar a aplicabilidade da metodologia de medição da temperatura de corte do aço ABNT 1045 utilizando-se ferramenta de corte de carbeto metálico revestida com TiN em contato com termopar do tipo K conectado a um circuito de leitura composto de um Arduíno Uno e um computador. Foram testados dez avanços para três grupos de velocidade de corte: 220 m/min, 110 m/min e 55 m/min e os resultados mostram-se promissores corroborando com a previsão realizada pela teoria clássica de usinagem. Além disso, foi usada a ferramenta Planejamento de Experimentos (DOE) para verificar a convergência do modelo prático, otimizando o processo produtivo com a geração de menos calor possível aumentando, desta forma. a vida da ferramenta (que são caras), controlando o uso de fluido de corte (nocivo ao ambiente), além de obter uma qualidade superficial superior da peça usinada.
Organoleptic characteristics of the classification of carcasses from bovine cattle in the tropics of veracruzano / Características organolepticas de la clasificación de canales procedentes de ganado bovino en el tropico veracruzano
Authors: Núñez Amalia Cabrera , Villagomez Miguel Angel Lammoglia , Ronquillo María Rebeca Rojas , Sánchez César Enrique Martínez , Solís Flor María Montero , Montes Daniel Sokani Sánchez , Fuentes Jorge Luis Chagoya 
Published: July 2022

This research work was carried out in a municipal trail (TIF) in the North of Veracruz, Mexico, with the aim of physically analyzing the quality of beef. A sample of 90 male cattle, which were divided into the following groups: F1 pure Brahman (n=30), F2 Brahman Crossses/ Holstein (n=30) y F3 Brahman Crosses/ Brown Swiis (n=30), male cattle was used at 24 months of age. They received the same management and a food ration based on harinoline, soybean paste, grain corn, grain sage and a mixture of vitamins-minerals, which was offered to 3.5.0% (NRC, 2000) fresh water and forage to free access, averaging the 350 kg completed in intensive corral for slaughter during the 60 days of the experiment. The variables analyzed were: flesh color, fat color, marbling and texture. The results were evaluated through the STADISTIC programme, showing generally that cuts of meat from young uncastrated males with two years of age presented category A, characterized by white fat, with a deep red color, soft texture and abundant marbling in a rating of 11 and 12. Noting that young animals showed the best physical qualities in beef.
Some Analytical Perspectives of Nonlinear Circuits
Authors: Chakravorty Pragnan 
Published: July 2022

<p>It is well known from the extant circuit theories that some important nonlinear circuit configurations cannot be modeled analytically. The crux of this limitation is found to be the existence of non-ohmic resistances. Here, it is argued that the idea of non-ohmic resistances is misconceived and, based on a recent development, a pertinent interpretation of the Ohm's law is drawn whereby such limitations may be removed. The hypothesis of a newly proposed phenomenon, named induced change in resistance, is also presented here. </p>
Dampak Merdeka Belajar Kampus Merdeka Terhadap Kualitas Mahasiswa
Authors: Arsyad Aisyah Tiar , Widuhung Sisca Debyola 
Published: July 2022

<p><em>Kebijakan Merdeka Belajar Kampus Merdeka (MBKM) telah diluncurkan oleh Menteri Pendidikan dan Kebudayaan Indonesia pada tahun 2020. Universitas Al Azhar Indonesia sebagai Perguruan Tinggi yang mengikuti perkembangan kebijakan pemerintah pun telah melaksanakan kegiatan MBKM tersebut. Kegiatan MBKM khususnya di Fakultas Ekonomi dan Bisnis di Universitas Al Azhar Indonesia telah berjalan dan memasuki angkatan selanjutnya, maka dirasa perlu untuk melakukan evaluasi terhadap kegiatan tersebut. Tujuan dalam penelitian ini untuk mengetahui dampak kegiatan MBKM terhadap kualitas mahasiswa Fakultas Ekonomi dan Bisnis. Penelitian ini merupakan penelitian deskriptif dengan pendekatan metode survey dan FGD. Survey dilakukan pada mahasiswa yang mengikuti kegiatan MBKM dan dosen pengajar. FGD dilakukan dengan mengundang narasumber eksternal yang berpengalaman dalam kegiatan MBKM. Kesimpulan dari penelitian ini bahwa kegiatan MBKM berdampak positif terhadap kualitas mahasiswa Fakultas Ekonomi dan Bisnis, namun memiliki beberapa aspek yang perlu diperbaiki.</em></p><p><strong><em>Kata kunci - </em></strong><em>MBKM, dampak, kualitas, pembelajaran<strong></strong></em></p>