bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does prior uterine surgery increase the risks of uterine leiomyoma and adenomyosis? a retrospective study
Authors: MAVRAL Nihal , KIRICI Pınar , YAKUT Kadriye , AVŞAR Filiz 
Published: March 2022

Aim: Women frequently undergo obstetric and gynecologic surgeries throughout their life, and the two common gynecologic conditions are uterine leiomyoma (UL) and adenomyosis. This study aims to investigate the relationship between the presence and the types of prior uterine surgery and the risks of developing UL and adenomyosis.
Material and Method: This study is a single-center eleven-year cross-sectional study, in which we studied the effects of previous uterine surgery on developing UL and adenomyosis in patients who underwent hysterectomy for any indication in our hospital between 01/01/2004 and 31/12/2014.
Results: During the time period, 1299 eligible patients were included in the study. The median age was 49.0 years and the study population was mostly consisted of multigravid women. The overall prevalence of UL was 61.9% and the overall prevalence of adenomyosis was 18.3%.In the univariate analysis of patient characteristics for UL, age, gravida and parity were found as statistically significant protective factors for UL (OR [95.0% CI]: 0.92 [0.91-0.93], 0.91 [0.88-0.95], 0.88 [0.83-0.93], respectively). On the other hand, women who underwent previous any uterine surgery had 1.28 folded (95.0% CI: 1.02-1.61) risk for UL. However, we found that only undergoing myomectomy statistically significantly increased the risk of UL (OR [95.0% CI]: 8.59 [2.62-27.91]) among the types of uterine surgery. In the multivariate model, the protective effect of age remained (adjusted OR [95.0% CI]: 0.92 [0.91-0.94]), and the risk-increasing effect of having previous myomectomy dropped slightly with retaining its statistical significance (adjusted OR [95.0% CI]: 5.87 [1.78-19.41]). We also conducted similar analysis for adenomyosis, and we found that gravida was a risk factor (OR [95.0% CI]: 1.06 [1.01-1.12]), conversely to its risk-decreasing effect for UL. Also, women who had a history of any uterine surgery had 1.42 folded (95.0% CI: 1.07-1.88), and women who had a history of D&C had 1.62 folded (95.0% CI: 1.02-1.61) risk adenomyosis. In the multivariate model for the risk of adenomyosis, the risk-increasing effects of the gravida and the history of D&C decreased very slightly with saving their statistical significances (adjusted OR [95.0% CI]: 1.06 [1.01-1.12], 1.44 [1.07-1.95], respectively).
Conclusion: According to our findings, the frequency of adenomyosis is higher but, the frequency of UL is compatible with the literature. Patients, who underwent uterine surgery previously, diagnosed with adenomyosis and UL more than the others who did not, but this seems to be a correlation rather than a causative association.
ANALISIS KEMAMPUAN PENALARAN MATEMATIS MAHASISWA DALAM MENYELESAIKAN SOAL GRUP
Authors: Ellu Reliyanti Natalia , Mamoh Oktovianus , Suddin Sulasri 
Published: March 2022

Mata kuliah struktur aljabar merupakan salah satu mata kuliah wajib dalam program studi pendidikan matematika. Salah satu topik yang dibahas dalam mata kuliah struktur aljabar adalah teori grup. Teori grup merupakan mata kuliah struktur aljabar yang memperkenalkan konsep tentang aljabar modern sehingga dalam mempelajarinya mahasiswa dituntut untuk memiliki kemampuan berpikir logis dan bernalar secara sistematis karena mata kuliah struktur aljabar sarat dengan definisi dan teorema. Tujuan dari penelitian ini adalah untuk mendeskripsikan kemampuan penalaran matematis mahasiswa dalam menyelesaikan soal grup. Metode yang di gunakan dalam penelitian ini adalah pendekatan kualitatif, penelitian ini telah dilaksanakan di program studi pendidikan matematika Universitas Timor, tahun 2021. Hasil penelitian menunjukan bahwa mahasiswa yang berkemampuan tinggi dinyatakan mampu bernalar pada seluruh tahap kemampuan penalaran matematis yaitu tahap analize, generalize, shyntesize dan justify, mahasiswa yang berkemampuan sedang dinyatakan mampu bernalar pada tahap analize dan generalize, sedangkan mahasiswa yang berkemampuan rendah hanya mampu bernalar pada tahap analize.
Kata Kunci: Analisis Kemampuan Penalaran; Soal grup
Transformative Community: Gathering the Untold Stories of Collaborative Research and Community Re-integration for Indigenous and non-Indigenous peoples, Post-Incarceration and Beyond
Authors: Crier Nicolas , Timler Kelsey , Keating Patrick , Young Pam , Brown Helen , Price Roberta 
Published: March 2022

The Canadian carceral system is purposefully designed to disconnect and isolate people. Ongoing colonialism in Canada at the intersection of carceral, social service, health and child welfare systems has resulted in the disproportionate and unjust representation of Indigenous Peoples across each stage of the penal process. Given the ongoing silencing of people who are or have been incarcerated, Participatory Action Research led by Peers with living experience of the carceral state and grounded in the wisdom of Indigenous Elders is urgently needed. In this context, a research network, called the Transformative Health & Justice Research Cluster (THJRC), based out of Vancouver, British Columbia, has formed to disrupt status quo research practices, bringing together Indigenous and non-Indigenous Peer Leaders, Elders, academics, community advocates and student trainees, and support the empowerment of people who have been incarcerated. In this reflective piece, Nicolas Crier, one of the THJRC Peer Leaders, will provide an overview of the who, what, why, when and how of the THJRC, reflecting on the impacts and strengths of the collaborative community in general, as well as within the specific context of COVID-19. Co-authors, representing diverse positionalities and perspectives within the THJRC, will weigh in when relevant.
Ti3C2Tx MXene-Coated Electrospun PCL Conduits for Enhancing Neurite Regeneration and Angiogenesis
Authors: Nan Li-Ping , Lin Zeng , Wang Feng , Jin Xue-Han , Fang Jia-Qi , Xu Bo , Liu Shu-Hao , Zhang Fan , Wu Zhong , Zhou Zi-Fei , Chen Feng , Cao Wen-Tao , Wang Jian-Guang , Liu Jun-Jian 
Published: March 2022

An electrical signal is the key basis of normal physiological function of the nerve, and the stimulation of the electric signal also plays a very special role in the repair process of nerve injury. Electric stimulation is shown to be effective in promoting axonal regeneration and myelination, thereby promoting nerve injury repair. At present, it is considered that electric conduction recovery is a key aspect of regeneration and repair of long nerve defects. Conductive neural scaffolds have attracted more and more attention due to their similar electrical properties and good biocompatibility with normal nerves. Herein, PCL and MXene-PCL nerve guidance conduits (NGCs) were prepared; their effect on nerve regeneration was evaluated in vitro and in vivo. The results show that the NGCs have good biocompatibility in vitro. Furthermore, a sciatic nerve defect model (15 mm) of SD rats was made, and then the fabricated NGCs were implanted. MXene-PCL NGCs show similar results with the autograft in the sciatic function index, electrophysiological examination, angiogenesis, and morphological nerve regeneration. It is possible that the conductive MXene-PCL NGC could transmit physiological neural electric signals, induce angiogenesis, and stimulate nerve regeneration. This paper presents a novel design of MXene-PCL NGC that could transmit self-originated electric stimulation. In the future, it can be combined with other features to promote nerve regeneration.
A Study of the Effects of Tornado Translation on Wind Loading Using a Potential Flow Model
Authors: Huo Shuan , Wang Jin , Haan Fred L. , Kopp Gregory A. , Sterling Mark 
Published: March 2022

This paper investigates the effects of tornado translation on pressure and overall force experienced by an airfoil subjected to tornado loading and presents a framework to reproduce the flow conditions and effects of a moving tornado. A thin symmetrical airfoil was used to explore the effects of tornado translation on a body. A panel method was used to compute the flow around an airfoil and an idealised tornado is represented using a moving vortex via unsteady potential flow. Analysis showed that the maximum overall pressure at a point was found to increase by up to 20% when the normalised translating velocity was 10% of the tangential velocity, but increases up to 60% when the normalised translating velocity is 30% of the tangential velocity. Investigation on the impact of varying airfoil thickness (Case 2) revealed that the location of the tornado has significant effect on the overall lift force. However, the overall lift force appeared to be largely insensitive to the tornado translation velocity due gross changes in pressure on either side of the airfoil cancelling each other out. Further comparison with varying airfoil sizes and distance to tornado translating path (Case 3) showed that the relative inflow and outflow angle is the primary factor affecting the lift on the airfoil. Additionally, the maximum forces on a body subjected to a moving tornado can be predicted using uniform flow providing that the appropriate range of inflow angles are known. Based on the analysis on the database of National Oceanic and Atmospheric Administration (NOAA), the normalised translation speed of the recorded tornadoes across the EF scales, appears to vary from 0.25 to 0.37, with an average of 0.32 (∼18.8 m/s). Finally, the framework using uniform flow to reproduce the flow conditions which are comparable to those generated by a translating vortex simulator is proposed and discussed in detail.
Whole-Exome Sequencing Identifies a Novel CPT2 Mutation in a Pedigree With Gout
Authors: Guo Yong , Jin Jing , Zhou Zhenni , Chen Yihui , Sun Li , Zhang Chunwu , Xia Xiaoru 
Published: March 2022

Background: Gout is a common inflammatory arthritis, and its exact pathogenesis remains unclear. Multiple studies have demonstrated that genetic factors play important roles in the development of gout. This study aims to investigate the genetic basis of gout in a three-generation pedigree of affected individuals.Methods: Whole-exome sequencing (WES), comprehensive variant analyses, and co-segregation testing were performed. The effects of candidate variants on protein localization and cellular expression were analyzed, as were interactions with gout-related genes.Results: After comprehensive bioinformatic analysis, Sanger sequencing validation, and pedigree co-segregation analysis, we identified a rare heterozygous missense variant (c.1891C &gt; T, p.R631C) in CPT2. Although no associated changes in localization were observed, the fluorescence intensity of p.R631C mutants was obviously reduced in comparison to the wild-type protein, suggesting that protein degradation is induced by the mutant. Furthermore, our results also indicate that the c.1891C &gt; T variant influences the ability of CPT2 to bind UCP2.Conclusion: This study identified a rare CPT2 mutation in a large Chinese pedigree with gout. Functional studies were used to define the effect of this mutant. This study provides novel insight into the genetic etiology of gout.
Recent Update on Retinoic Acid-Driven Initiation of Spermatogonial Differentiation
Authors: Bhattacharya Indrashis , Sharma Partigya , Purohit Shriya , Kothiyal Sachin , Das Moitreyi , Banerjee Arnab 
Published: March 2022

Germ cells (Gc) propagate the genetic information to subsequent generations. Diploid (2n) Gc get transformed to specialized haploid (n) gametes by mitotic and meiotic divisions in adult gonads. Retinoic acid (RA), an active derivative of vitamin A (retinol), plays a critical role in organ morphogenesis and regulates the meiotic onset in developing Gc. Unlike ovaries, fetal testes express an RA-degrading enzyme CYP26B1, and thereby, male Gc fail to enter into meiosis and instead get arrested at G0/G1 stage, termed as gonocytes/pro-spermatogonia by embryonic (E) 13.5 days. These gonocytes are transformed into spermatogonial stem/progenitor cells after birth (1–3 days of neonatal age). During post-natal testicular maturation, the differentiating spermatogonia enter into the meiotic prophase under the influence RA, independent of gonadotropic (both FSH and LH) support. The first pulse of RA ensures the transition of undifferentiated type A spermatogonia to differentiated A1 spermatogonia and upregulates STRA8 expression in Gc. Whereas, the second pulse of RA induces the meiotic prophase by augmenting MEIOSIN expression in differentiated spermatogonia B. This opinion article briefly reviews our current understanding on the RA-driven spermatogonial differentiation in murine testes.
Characterization of Cortical Glial Scars in the Diisopropylfluorophosphate (DFP) Rat Model of Epilepsy
Authors: Gage Meghan , Gard Megan , Thippeswamy Thimmasettappa 
Published: March 2022

Glial scars have been observed following stab lesions in the spinal cord and brain but not observed and characterized in chemoconvulsant-induced epilepsy models. Epilepsy is a disorder characterized by spontaneous recurrent seizures and can be modeled in rodents. Diisopropylfluorophosphate (DFP) exposure, like other real-world organophosphate nerve agents (OPNAs) used in chemical warfare scenarios, can lead to the development of status epilepticus (SE). We have previously demonstrated that DFP-induced SE promotes epileptogenesis which is characterized by the development of spontaneous recurrent seizures (SRS), gliosis, and neurodegeneration. In this study, we report classical glial scars developed in the piriform cortex, but not in the hippocampus, by 8 days post-exposure. We challenged both male and female rats with 4–5 mg/kg DFP (s.c.) followed immediately by 2 mg/kg atropine sulfate (i.m.) and 25 mg/kg pralidoxime (i.m.) and one hour later by midazolam (i.m). Glial scars were present in the piriform cortex/amygdala region in 73% of the DFP treated animals. No scars were found in controls. Scars were characterized by a massive clustering of reactive microglia surrounded by hypertrophic reactive astrocytes. The core of the scars was filled with a significant increase of IBA1 and CD68 positive cells and a significant reduction in NeuN positive cells compared to the periphery of the scars. There was a significantly higher density of reactive GFAP, complement 3 (C3), and inducible nitric oxide synthase (iNOS) positive cells at the periphery of the scar compared to similar areas in controls. We found a significant increase in chondroitin sulfate proteoglycans (CS-56) in the periphery of the scars compared to a similar region in control brains. However, there was no change in TGF-β1 or TGF-β2 positive cells in or around the scars in DFP-exposed animals compared to controls. In contrast to stab-induced scars, we did not find fibroblasts (Thy1.1) in the scar core or periphery. There were sex differences with respect to the density of iNOS, CD68, NeuN, GFAP, C3 and CS-56 positive cells. This is the first report of cortical glial scars in rodents with systemic chemoconvulsant-induced SE. Further investigation could help to elucidate the mechanisms of scar development and mitigation strategies.
Electrochemical Sensing of Nitrite Ions Using Modified Electrode by Poly 1,8-Diaminonaphthalene/Functionalized Multi-Walled Carbon Nanotubes
Authors: Salhi Ouissal , Ez-zine Tarik , Oularbi Larbi , El Rhazi Mama 
Published: March 2022

A novel electrochemical sensor based on conducting polymer and multi-walled carbon nanotubes was reported for the detection of nitrite ions (NO2−). The hybrid material poly 1,8-Diaminonaphthalene (poly 1,8-DAN)/functionalized multi-walled carbon nanotubes (f-MWCNT) was prepared by using a simple electrochemical approach which is based on the deposition of functionalized multi-walled carbon nanotubes (f-MWCNT) on the surface of the electrode followed by the electropolymerization of 1,8-DAN using cyclic voltammetry. The morphology and the electro-catalytic properties of the obtained electrodes were investigated with Fourier Transform Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), Cyclic Voltammetry (CV), and Electrochemical Impedance Spectroscopy (EIS) showing an improvement of the electronic transfer due to the synergic effect between the proprieties of poly 1,8-DAN and f-MWCNT. Under the optimum experimental conditions, the poly 1,8-DAN/f-MWCNT/CPE exhibited excellent electro-catalytic activity towards nitrite detection. The nitrite anodic peak potential decreased by 210 mV compared to the bare carbon paste electrode. The calibration plot of nitrite detection was linear in the range of concentration from 300 to 6500 nM with a low detection limit of 75 nM.
Diagnostic Value of 11C-PIB PET/MR in Cardiac Amyloidosis
Authors: Bi Xiao , Xu Baixuan , Liu Jiajin , Wang Guanyun , An Jing , Zhang Xiaojun , Wang Ruimin , Dong Wei , Guan Zhiwei 
Published: March 2022

BackgroundThe thioflavin T derivative, 11C-Pittsburgh-B (PIB), is used for Alzheimer's disease imaging because it specifically binds to β-amyloid protein deposits in the brain. The aim of this study was to estimate the diagnostic value of combined 11C-PIB positron emission tomography/magnetic resonance (PET/MR) in cardiac amyloidosis (CA).MethodsWe enrolled 23 heart failure patients with suspected CA based on echocardiographic and electrocardiograph findings. All patients underwent cardiac 11C-PIB PET/MR and non-cardiac biopsy within one week. We also enrolled eight healthy volunteers that underwent cardiac 11C-PIB PET/MR as a control group. The cardiac magnetic resonance (CMR) protocol included cine imaging, late gadolinium enhancement (LGE), and native and post-contrast T1 mapping. Extracellular volume (ECV) was measured using pre- and post-contrast T1 mapping images. LVEF, IVSD, LVPW, LVmass, LVESV, LVEDV, native T1 value, ECV, and maximum uptake of myocardial tissue-to-blood background ratio (TBR) values were obtained from PET/MR images in all patients and healthy subjects.ResultsThirteen out of twenty-three heart failure patients were clinically diagnosed with CA. The remaining 10 patients were CA-negative (non-CA patient group). Twelve of the thirteen CA patients showed diffuse transmural LGE patterns, whereas LGE was either absent or patchy in the non-CA patients. The diagnostic sensitivity and specificity of TBRmax were 92.3 and 100%, respectively, at a cut-off value of 1.09. Several CMR imaging parameters (LVEF, IVSD, LVmass, LVEDV, LVESV, LVPW, native T1 value and ECV) and TBR showed significant differences between CA patients, non-CA patients, and healthy controls (P &lt; 0.05). Native T1 mapping values positively correlated with TBRmax values in CA and non-CA patients (r = 0.38, P = 0.0004).Conclusions11C-PIB PET/MRI is a valuable tool for the accurate and non-invasive diagnosis of CA because it distinguishes CA patients from non-CA patients and healthy subjects with high specificity and sensitivity. Moreover, native T1 mapping values positively correlated with TBRmax values in CA and non-CA patients. In the future, larger cohort studies are necessary to confirm our findings.
Fibroblast Growth Factor 21 Predicts Short-Term Prognosis in Patients With Acute Heart Failure: A Prospective Cohort Study
Authors: Wu Guihai , Wu Shenglin , Yan Jingyi , Gao Shanshan , Zhu Jinxiu , Yue Minghui , Li Zexin , Tan Xuerui 
Published: March 2022

BackgroundRecent studies of fibroblast growth factor 21 (FGF21), first recognized as a regulator of glucose and lipid metabolism, have found that the level of in serum FGF21 is associated with the prognosis of many cardiovascular diseases, but its relationship to acute heart failure (AHF) patients remains unknown. Our study aimed to investigate whether circulating FGF21 could predict the short-term prognosis of AHF patients.MethodsFour hundred and two AHF patients and 19 healthy controls were recruited into the prospective cohort study, and blood samples of participants were collected, in tubes without anticoagulant, within the first 24 h after hospital admission. Serum FGF21 levels were detected by enzyme-linked immunosorbent assay (ELISA). All patients were followed-up at least 6 months after discharge. The primary endpoint was all-cause death, and secondary endpoint was a composite endpoint of death and heart failure readmission. Mortality and composite end point events were analyzed using Kaplan-Meier curves. ROC curves compared the difference between the FGF21 and NT-proBNP in predicting 3- and 6-months mortality. Time-to-event data were evaluated using Kaplan-Meier estimation and Cox proportional hazards models.ResultsIn the present study, the serum FGF21 concentrations were significantly higher in the 402 AHF patients enrolled, compared with the 19 healthy controls (p &lt; 0.001). The average age was 70 (±12) years, and 58% were males. Participants were divided into two groups according to the median FGF21 level (262 pg/ml): a high FGF21 group (n = 201, FGF21 ≥ 262 pg/ml) and low FGF21 group (n = 201, FGF21 &lt;262 pg/ml). FGF21 was positively correlated with NT-proBNP, BUN, AST, creatinine and cholesterol, and negatively correlated with ALB and HDL. After a median follow-up of 193 days, the high FGF21 group had higher mortality and composite endpoint events compared with the low FGF21 group (HR: 3.91, 95% CI 2.21–6.92, p &lt;0.001), even after adjusting for NT-proBNP (HR: 3.17, 95% CI 1.72–5.81, p &lt; 0.001). ROC analysis shows that FGF21 was better than NT-proBNP in predicting death at both 3 (AUC, 0.77 vs. 0.63, p &lt; 0.001) and 6 months (AUC, 0.78 vs. 0.66).ConclusionHigh baseline FGF21 levels are associated with adverse clinical outcomes in AHF patients. Serum FGF21 might be a potential predictive biomarker of AHF patients.