bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient SVDD sampling with approximation guarantees for the decision boundary
Authors: Englhardt Adrian , Trittenbach Holger , Kottke Daniel , Sick Bernhard , Böhm Klemens 
Published: April 2022

AbstractSupport Vector Data Description (SVDD) is a popular one-class classifier for anomaly and novelty detection. But despite its effectiveness, SVDD does not scale well with data size. To avoid prohibitive training times, sampling methods select small subsets of the training data on which SVDD trains a decision boundary hopefully equivalent to the one obtained on the full data set. According to the literature, a good sample should therefore contain so-called boundary observations that SVDD would select as support vectors on the full data set. However, non-boundary observations also are essential to not fragment contiguous inlier regions and avoid poor classification accuracy. Other aspects, such as selecting a sufficiently representative sample, are important as well. But existing sampling methods largely overlook them, resulting in poor classification accuracy. In this article, we study how to select a sample considering these points. Our approach is to frame SVDD sampling as an optimization problem, where constraints guarantee that sampling indeed approximates the original decision boundary. We then propose RAPID, an efficient algorithm to solve this optimization problem. RAPID does not require any tuning of parameters, is easy to implement and scales well to large data sets. We evaluate our approach on real-world and synthetic data. Our evaluation is the most comprehensive one for SVDD sampling so far. Our results show that RAPID outperforms its competitors in classification accuracy, in sample size, and in runtime.
Impairment of mitochondrial respiration in platelets and placentas: a pilot study in preeclamptic pregnancies
Authors: Bînă Anca M. , Aburel Oana M. , Avram Vlad F. , Lelcu Theia , Lința Adina V. , Chiriac Daniela V. , Mocanu Adelina G. , Bernad Elena , Borza Claudia , Craina Marius L. , Popa Zoran L. , Muntean Danina M. , Crețu Octavian M. 
Published: April 2022

AbstractPreeclampsia (PE) is a major complication of pregnancy with partially elucidated pathophysiology. Placental mitochondrial dysfunction has been increasingly studied as major pathomechanism in both early- and late-onset PE. Impairment of mitochondrial respiration in platelets has recently emerged as a peripheral biomarker that may mirror organ mitochondrial dysfunction in several acute and chronic pathologies. The present study was purported to assess mitochondrial respiratory dys/function in both platelets and placental mitochondria in PE pregnancies. To this aim, a high-resolution respirometry SUIT (Substrate-Uncoupler-Inhibitor-Titration) protocol was adapted to assess complex I (glutamate + malate)- and complex II (succinate)-supported respiration. A decrease in all respiratory parameters (basal, coupled, and maximal uncoupled respiration) in peripheral platelets was found in preeclamptic as compared to healthy pregnancies. At variance, placental mitochondria showed a dichotomous behavior in preeclampsia in relation to the fetal birth weight. PE pregnancies with fetal growth restriction were associated with decreased in coupled respiration (oxidative phosphorylation/OXPHOS capacity) and maximal uncoupled respiration (electron transfer/ET capacity). At variance, these respiratory parameters were increased for both complex I- and II-supported respiration in PE pregnancies with normal weight fetuses. Large randomized controlled clinical studies are needed in order to advance our understanding of mitochondrial adaptive vs. pathological changes in preeclampsia.
Predicting the future impact of Computer Science researchers: Is there a gender bias?
Authors: Kuppler Matthias 
Published: April 2022

AbstractThe advent of large-scale bibliographic databases and powerful prediction algorithms led to calls for data-driven approaches for targeting scarce funds at researchers with high predicted future scientific impact. The potential side-effects and fairness implications of such approaches are unknown, however. Using a large-scale bibliographic data set of N = 111,156 Computer Science researchers active from 1993 to 2016, I build and evaluate a realistic scientific impact prediction model. Given the persistent under-representation of women in Computer Science, the model is audited for disparate impact based on gender. Random forests and Gradient Boosting Machines are used to predict researchers’ h-index in 2010 from their bibliographic profiles in 2005. Based on model predictions, it is determined whether the researcher will become a high-performer with an h-index in the top-25% of the discipline-specific h-index distribution. The models predict the future h-index with an accuracy of $$R^2 = 0.875$$

R
2

=
0.875

and correctly classify 91.0% of researchers as high-performers and low-performers. Overall accuracy does not vary strongly across researcher gender. Nevertheless, there is indication of disparate impact against women. The models under-estimate the true h-index of female researchers more strongly than the h-index of male researchers. Further, women are 8.6% less likely to be predicted to become high-performers than men. In practice, hiring, tenure, and funding decisions that are based on model predictions risk to perpetuate the under-representation of women in Computer Science.
Diagnostic Classification Analysis of Problem-Solving Competence using Process Data: An Item Expansion Method
Authors: Zhan Peida , Qiao Xin 
Published: April 2022

AbstractProcess data refer to data recorded in computer-based assessments (CBAs) that reflect respondents’ problem-solving processes and provide greater insight into how respondents solve problems, in addition to how well they solve them. Using the rich information contained in process data, this study proposed an item expansion method to analyze action-level process data from the perspective of diagnostic classification in order to comprehensively understand respondents’ problem-solving competence. The proposed method cannot only estimate respondents’ problem-solving ability along a continuum, but also classify respondents according to their problem-solving skills. To illustrate the application and advantages of the proposed method, a Programme for International Student Assessment (PISA) problem-solving item was used. The results indicated that (a) the estimated latent classes provided more detailed diagnoses of respondents’ problem-solving skills than the observed score categories; (b) although only one item was used, the estimated higher-order latent ability reflected the respondents’ problem-solving ability more accurately than the unidimensional latent ability estimated from the outcome data; and (c) interactions among problem-solving skills followed the conjunctive condensation rule, which indicated that the specific action sequence appeared only when a respondent mastered all required problem solving skills. In conclusion, the proposed diagnostic classification approach is feasible and promising analyzing process data.
Factors Associated with Post-Acute Sequelae of SARS-CoV-2 (PASC) After Diagnosis of Symptomatic COVID-19 in the Inpatient and Outpatient Setting in a Diverse Cohort
Authors: Yoo Sun M. , Liu Teresa C. , Motwani Yash , Sim Myung S. , Viswanathan Nisha , Samras Nathan , Hsu Felicia , Wenger Neil S. 
Published: April 2022

ABSTRACT
Background
The incidence of persistent clinical symptoms and risk factors in Post-Acute Sequelae of SARS-CoV-2 (PASC) in diverse US cohorts is unclear. While there are a disproportionate share of COVID-19 deaths in older patients, ethnic minorities, and socially disadvantaged populations in the USA, little information is available on the association of these factors and PASC.

Objective
To evaluate the association of demographic and clinical characteristics with development of PASC.

Design
Prospective observational cohort of hospitalized and high-risk outpatients, April 2020 to February 2021.

Participants
One thousand thirty-eight adults with laboratory-confirmed symptomatic COVID-19 infection.

Main Measures
Development of PASC determined by patient report of persistent symptoms on questionnaires conducted 60 or 90 days after COVID-19 infection or hospital discharge. Demographic and clinical factors associated with PASC.

Key Results
Of 1,038 patients with longitudinal follow-up, 309 patients (29.8%) developed PASC. The most common persistent symptom was fatigue (31.4%) followed by shortness of breath (15.4%) in hospitalized patients and anosmia (15.9%) in outpatients. Hospitalization for COVID-19 (odds ratio [OR] 1.49, 95% [CI] 1.04–2.14), having diabetes (OR, 1.39; 95% CI 1.02–1.88), and higher BMI (OR, 1.02; 95% CI 1–1.04) were independently associated with PASC. Medicaid compared to commercial insurance (OR, 0.49; 95% CI 0.31–0.77) and having had an organ transplant (OR 0.44, 95% CI, 0.26–0.76) were inversely associated with PASC. Age, race/ethnicity, Social Vulnerability Index, and baseline functional status were not associated with developing PASC.

Conclusions
Three in ten survivors with COVID-19 developed a subset of symptoms associated with PASC in our cohort. While ethnic minorities, older age, and social disadvantage are associated with worse acute COVID-19 infection and greater risk of death, our study found no association between these factors and PASC.
Unravelling hidden factors explaining competition for and overuse of groundwater in Azraq, Jordan: digging deeper into a network of action situations
Authors: Oberhauser Daniel , Hägele Ramona , Dombrowsky Ines 
Published: April 2022

AbstractIn Azraq in Eastern Jordan, farmers, domestic users, and a wetland ecosystem compete for and overexploit limited groundwater resources. Current studies explain parts of the problem, but do not take a comprehensive social–ecological systems perspective and tend to miss underlying hidden factors. To explain decision-making in this complex social–ecological system, we combine the concept of networks of action situations (NAS) with the political economy concept of the social contract. While the NAS allows a systematic exploration of the system, the concept of the social contract allows a deeper understanding of how informal institutions and power influence the system. Besides a comprehensive literature review, we draw on social network mapping and 67 semi-structured interviews with relevant stakeholders. We find that the main conflict arises between a heterogeneous group of farmers, who use groundwater for irrigation agriculture supported by a strong political lobby, and the water authorities, which rely on the aquifer for domestic water supply at national level. The original wetland with its diverse ecosystem services has largely disappeared and its remainder is maintained artificially. Our analysis reveals that a diversity of action situations, including water, agricultural, environmental, energy, and land governance, but also the monarchy’s underlying social contract and the informal concept of wasta, influence outcomes on the ground. We show that no panacea exists, but that systems thinking may help identify a range of intervention points, some more sensitive than others, that could support a social–ecological transformation towards sustainability.
Private Forestlands in South Carolina: Motivations for Implementing Conservation Practices
Authors: Clay Lucas , Perkins Katharine , Motallebi Marzieh 
Published: April 2022

AbstractThis study aims to understand the conservation practices taking place on private forestlands in South Carolina, United States. Much of the forestlands in the eastern United States are privately owned, and landowners can elect whether to implement conservation practices. A questionnaire was distributed to South Carolina landowners to elicit information on land tenure, the type of conservation practices they use, and the best methods for increasing the use of these practices. We specifically focused on prescribed fire because of its importance to management regimes and the debate that surrounds this practice. Results from our questionnaire that was randomly distributed to South Carolina forest landowners showed that many landowners use at least one conservation practice or are interested in implementing one or more practice. Our Logit regression analysis showed that certain factors including land size and belonging to an environmental group were significant and associated with increased implementation of prescribe fire. From the model and statistical analysis of the landowner responses, we inferred that educational and financial resources are two crucial factors for encouraging landowners to implement conservation practices and retain landowners already involved in the cost share programs. Furthermore, helping landowners with implementation of prescribed fire through their inclusion in prescribed fire organizations and funding opportunities would most likely increase adoption and contribute to conserving ecosystem services in South Carolina and other states with large areas of land in private ownership.
Sex-Related Differences in Patients’ Characteristics, Provided Care, and Outcomes Following Spontaneous Intracerebral Hemorrhage
Authors: Wang Sophie Shih-Yüng , Bögli Stefan Yu , Nierobisch Nathalie , Wildbolz Stella , Keller Emanuela , Brandi Giovanna 
Published: April 2022

Abstract
Background
Sex-related differences in patients with spontaneous, non-traumatic intracerebral hemorrhage (ICH) are poorly investigated so far. This study elucidates whether sex-related differences in ICH care in a neurocritical care setting exist, particularly regarding provided care, while also taking patient characteristics, and outcomes into account.

Methods
This retrospective single center study includes all consecutive patients with spontaneous ICH admitted to the neurocritical care unit in a 10-year period. Patients’ demographics, comorbidities, symptoms at presentation, radiological findings, surgical and medical provided care, intensive care unit mortality and 12 month-mortality, and functional outcome at discharge were compared among men and women.

Results
Overall, 398 patients were included (male = 198 and female = 200). No differences in demographics, Charlson Comorbidity Index (CCI), symptoms at presentation, radiological findings, intensive care unit mortality and 12-month mortality were observed among men and women. Men received an external ventricular drain (EVD) for hydrocephalus-therapy significantly more often than women, despite similar location of the ICH and radiographic parameters. In the multivariate analysis, EVD insertion was independently associated with male sex (odds ratio 2.82, 95% confidence interval 1.61–4.95, P < 0.001) irrespective of demographic or radiological features. Functional outcome after ICH as assessed by the modified Rankin scale, was more favorable for women (P = 0.044).

Conclusions
Sex-related differences in patients with ICH regarding to provided neurosurgical care exist. We provide evidence that insertion of EVD is associated with male sex, disregarding clear reasoning. A sex-bias as well as social factors may play a significant role in decision-making for the insertion of an EVD.
Understanding Coping Mechanisms during the COVID-19 Pandemic: A Case Study of Stakeholders of the African Sisters Education Collaborative
Authors: Draru Mary Cecilia , Lopatofsky Tara , Karimi Kevin , Gautier Mary L. 
Published: April 2022

Background The African Sisters Education Collaborative (ASEC) operates education programs for women religious in ten countries of Africa south of the Sahara. As ASEC prioritizes strong relationships with partner institutions, understanding the impact of the COVID-19 pandemic on these stakeholders is central to providing effective interventions that will ensure continuation of its programs. Purpose The purpose of this study was to obtain an organizational understanding of stakeholders' ministry/work stress and coping mechanisms during the initial phase of the pandemic. ASEC surveyed its more than 3,500 stakeholders to assess their ministry/work stress, sources of emotional well-being, and coping skills during the early months of the pandemic. The study was designed to provide information to help ASEC initiate a proactive response to the pandemic at an organizational level. Methods ASEC prepared a brief online survey that was distributed from late April through mid-May 2020. Scales to measure emotional well-being, coping skills, ministry/work stress, and sources of pandemic support were researcher-designed. Lockdown status of the country at the time of the survey was used as a proxy measure of severity of the pandemic. Results Religious sisters who have participated in ASEC's education programs experienced increased stress in their ministry/work settings, particularly in countries that were under lockdown at the time of the survey. Ministry/work stress was lessened by individual coping skills and sense of emotional well-being, as predicted by the balanced affect literature on ministry stress among religious workers. Working under lockdown, lower levels of ministry/work stress, and confidence in one's coping skills all positively impacted emotional well-being. In turn, emotional well-being was significantly related to greater coping skills, which was also impacted by lower levels of ministry/work stress and greater sources of pandemic support. Conclusions and Implications The pandemic has negatively impacted the ministries and work settings of these stakeholders, which has influenced their personal emotional well-being as well as their assessment of their coping skills. Positive attitudes about their ability to cope and their emotional well-being reduced their levels of ministry/work stress.
Novel Marker for Premature Ejaculation: Serum Leptin Level
Authors: Liu Guodong , Zhang Yuyang , Zhang Wei , Wu Xu , Gao Hui , Jiang Hui , Dai Yutian , Zhang Xiansheng 
Published: April 2022

ABSTRACT

Background
Leptin, which was only discovered in humans in 1994, has recently been shown to have a possible link with premature ejaculation.

Aim
To evaluate whether serum leptin levels differed between patients with premature ejaculation and healthy men, and to analyze the changes in leptin levels before and after treatment.

Methods
Six studies assessing the relationship between leptin and premature ejaculation published up to October 2021 were identified from multiple databases (PubMed, Web of Science, Cochrane) and the data were analyzed by Stata software.

Outcomes
Differences in leptin levels in premature ejaculation patients and healthy people, and changes of leptin levels in premature ejaculation population before and after treatment.

Results
Analysis of studies assessing differences in leptin concentrations between patients with PE and healthy men showed that there was a statistically significant difference in leptin levels between PE patients and controls (WMD (95% CI) = 17.89 (8.64, 27.14), P &lt; .001). On the other hand, the analysis of data from 3 studies describing serum leptin levels in PE patients before and after treatment with selective serotonin reuptake inhibitors (SSRIs) showed that there was a significant decrease with leptin levels in PE patients after treatment (WMD (95%CI) = 22.06 (17.21, 26.92), P &lt; .001).

Clinical Implications
It is possible that leptin can be used as a new marker for premature ejaculation.

Strength & Limitations
The strength of this study is that it is the first meta- analysis to assess the differences of serum leptin levels between patients with premature ejaculation and healthy subjects and the changes of leptin levels before and after treatment in patients with premature ejaculation. A major limitation is that a greater heterogeneity was identified through our analysis, however we did not find a definitive source of heterogeneity.

Conclusion
There was a statistically significant relationship between serum leptin levels and patients with PE. In addition, serum leptin levels in patients with PE decreased significantly after 8 weeks of treatment with SSRIs.
Music, Subjectivity, and Schumann
Authors: Taylor Benedict 
Published: April 2022

The concept of subjectivity is one of the most popular in recent scholarly accounts of music; it is also one of the obscurest and most ill-defined. Multifaceted and hard to pin down, subjectivity nevertheless serves an important, if not indispensable purpose, underpinning various assertions made about music and its effect on us. We may not be exactly sure what subjectivity is, but much of the reception of Western music over the last two centuries is premised upon it. Music, Subjectivity, and Schumann offers a critical examination of the notion of musical subjectivity and the first extended account of its applicability to one of the composers with whom it is most closely associated. Adopting a fluid and multivalent approach to a topic situated at the intersection of musicology, philosophy, literature, and cultural history, it seeks to provide a critical refinement of this idea and to elucidate both its importance and limits.
The impact of coronavirus disease 2019 (COVID-19) on the antimicrobial stewardship pharmacist workforce: A multicenter survey
Authors: Wimmer Megan R. , Schulz Lucas T. , Hamel Ashlee G. , Schwei Rebecca J. , Fong Karen , Burgess Donna R. , Brett Meghan , Hale Cory M. , Holubar Marisa , Jain Rupali , Larry Rachel , Spivak Emily S. , Newland Helen , Njoku Jessica , Postelnick Michael , Walraven Carla , Pulia Michael S. 
Published: April 2022

Abstract

Objective:
The coronavirus disease 2019 (COVID-19) pandemic has required healthcare systems and hospitals to rapidly modify standard practice, including antimicrobial stewardship services. Our study examines the impact of COVID-19 on the antimicrobial stewardship pharmacist.

Design:
A survey was distributed nationally to all healthcare improvement company members.

Participants:
Pharmacist participants were mostly leaders of antimicrobial stewardship programs distributed evenly across the United States and representing urban, suburban, and rural health-system practice sites.

Results:
Participants reported relative increases in time spent completing tasks related to medication access and preauthorization (300%; P = .018) and administrative meeting time (34%; P = .067) during the COVID-19 pandemic compared to before the pandemic. Time spent rounding, making interventions, performing pharmacokinetic services, and medication reconciliation decreased.

Conclusion:
A shift away from clinical activities may negatively affect the utilization of antimicrobials.
Mental health and wellbeing at work in the UK: current legal approaches
Authors: Almond Paul , Horton Rachel , James Grace 
Published: April 2022

AbstractIn this paper we outline and critique legal approaches to poor mental health at work in the UK. We argue that the current legal framework is not ‘fit for purpose’. Overall, the existing framework promotes a problematic model that is ineffective because each element, individually and as part of the whole, fails to adequately engage with the nuanced realities of the relationship between undertaking paid work and suffering poor mental health. It is, we suggest, disjointed because it has evolved from a patchwork of provisions, each with different foundations, motivations, ambitions and flaws. The need for a re-focus, and what this might entail, is considered, and the capacity of a model centred on addressing workplace mental health as a manifestation of broader notions of vulnerability is explored.