bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linear ubiquitin as a common regulator of cellular stress
Authors: Peltzer Nieves 
Published: March 2022

Linear or M1‐ubiquitination (Ub) is required for optimal NF‐kB activation and for cell death inhibition. Using Drosophila as a model organism, Aalto et al. found that hypoxia, oxidative and mechanical stress induced M1‐Ub by the HOIP homolog, LUBEL. Increased M1‐Ub had a protective function driven by activation of the NF‐κB transcription factor Relish via the Immune deficiency pathway (Imd). This protective M1‐Ub was also induced upon cellular stress in colorectal cancer cells. Collectively, they propose that M1‐Ub is a conserved, common response to different forms of stresses. These findings may have important implications for the use of HOIP inhibitors for cancer treatment.Comment on: https://doi.org/10.1111/febs.16425
The city of start‐ups: Location determinants of start‐ups in emergent industries in Barcelona
Authors: Coll‐Martínez Eva , Jové‐Llopis Elisenda , Teruel Mercedes 
Published: March 2022

AbstractIn recent years, scholars have highlighted the role of cities as incubators for start‐ups. Several studies identify the city of Barcelona as one of the major hubs in Europe for start‐up creation, especially in emergent industries. The present paper examines how local attributes, proximity to the elements of an entrepreneurial ecosystem (EE), and to nearby economic activity, influence the location of ambitious start‐ups in Barcelona between 2012 and 2015. To do this, we use micro‐geographic data of Barcelona start‐ups provided by the Catalan Government (ACCIÓ) and open data on the socioeconomic composition of Barcelona neighbourhoods from the Statistics Department of the Council of Barcelona. By dealing with neighbouring effects and endogeneity, our results suggest that localisation economies and proximity to the elements of the EE are the key factors attracting start‐ups to Barcelona's neighbourhoods. These results are crucial in helping policymakers understand the locational factors of start‐ups within the city.
Effectiveness of manual therapy in the treatment of cervicogenic headache: A systematic review
Authors: Núñez‐Cabaleiro Patricia , Leirós‐Rodríguez Raquel 
Published: March 2022

AbstractObjectiveThe aim of this study was to identify the manual therapy (MT) methods and techniques that have been evaluated for the treatment of cervicogenic headache (CH) and their effectiveness.BackgroundMT seems to be one of the options with the greatest potential for the treatment of CH, but the techniques to be applied are varied and there is no consensus on which are the most indicated.MethodsA systematic search in Scopus, Medline, PubMed, Cinahl, PEDro, and Web of Science with the terms: secondary headache disorders, physical therapy modalities, musculoskeletal manipulations, cervicogenic headache, manual therapy, and physical therapy. We included articles published from 2015 to the present that studied interventions with MT techniques in patients with CH. Two reviewers independently screened 365 articles for demographic information, characteristics of study design, study‐specific intervention, and results. The Oxford 2011 Levels of Evidence and the Jadad scale were used.ResultsOf a total of 14 articles selected, 11 were randomized control trials and three were quasi‐experimental studies. The techniques studied were: spinal manipulative therapy, Mulligan’s Sustained Natural Apophyseal Glides, muscle techniques, and translatory vertebral mobilization. In the short‐term, the Jones technique on the trapezius and ischemic compression on the sternocleidomastoid achieved immediate improvements, whereas adding spinal manipulative therapy to the treatment can maintain long‐term results.ConclusionsThe manual therapy techniques could be effective in the treatment of patients with CH. The combined use of MT techniques improved the results compared with using them separately. This review has methodological limitations, such as the inclusion of quasi‐experimental studies and studies with small sample sizes that reduced the generalizability of the results obtained.
Longitudinal analysis of new‐onset non‐AIDS‐defining diseases among people living with HIV: A real‐world observational study
Authors: Duan Yujiao , Zhao Hongxin , Tang Weiming , Chen Meiling , Liu Xuan , Yang Di , Gao Guiju , Xiao Jiang , Han Ning , Liang Hongyuan , Wu Liang , Ni Liang , Wang Fang , Song Yangzi , Xie Xiaohui , Zhang Fujie 
Published: March 2022

AbstractObjectivesWe aimed to analyze the incidence rates of new‐onset diabetes, hypertriglyceridemia, hypercholesterolemia, liver injury, and renal injury during antiretroviral therapy (ART) among people living with HIV (PLWH) and determine the associated risk factors.MethodsThis study included PLWH enrolled from Beijing Ditan Hospital from November 11, 2004, to December 29, 2018. The incidence rates of new‐onset diabetes, hypertriglyceridemia, hypercholesterolemia, liver injury, and renal injury were calculated and stratified based on ART regimen, CD4 count, and HIV‐RNA. Risk factors were determined using Cox regression analysis.ResultsOverall, 6747 participants were included. Moreover, 4.5%, 43.3%, 25.4%, 11.2%, and 6.2% of patients developed new‐onset diabetes, hypertriglyceridemia, hypercholesterolemia, liver injury, and renal injury, respectively, with incidence rates of 1.7, 26.9, 10.2, 3.9, and 5.5 per 100 person‐years, respectively. Longitudinally, the incidence rates and percentages of these outcomes were highest in the first year of ART. The percentage of dyslipidemia was significantly higher in protease inhibitor (PI)‐based regimen than in non‐nucleoside reverse transcriptase inhibitor (NNRTI)‐based regimen. However, the percentage of liver injury was significantly higher in NNRTI‐based regimen than in PI‐based regimen. In multivariate Cox regression analysis, low CD4 count (<200 cells/µL, adjusted hazard ratio [aHR] = 1.34, 95% confidence interval [CI] 1.15–1.57) and high HIV‐RNA (>105 copies/mL, aHR = 1.26, 95% CI 1.08–1.48) were risk factors for hypertriglyceridemia.ConclusionsClinical outcomes, including new‐onset diabetes, dyslipidemia, and liver and renal injuries, are common in PLWH. Regular glucose, lipid, liver, and renal function monitoring is required during ART, especially in high‐risk patients.
Distribution of nontuberculous mycobacteria in patients with and without HIV/AIDS in Chongqing
Authors: Nie Jingmin , Deng Xizi , Zeng Qingling , Du Xiang , Chen Yaokai , Hu Fengyu 
Published: March 2022

AbstractIntroductionIn this study, the distribution of nontuberculous mycobacteria (NTM) strains in patients with and without HIV/AIDS in Chongqing, China was evaluated.MethodsA retrospective study was performed in January–December 2020 at Chongqing Public Health Medical Center. NTM strains were assessed by a multi locus phylogenetic analysis. The distribution of NTM strains in HIV/AIDS and non‐HIV/AIDS groups was compared. CD4+ cell counts, imaging changes, and characteristics of mycobacterial species were determined.ResultsIn total, 324 patients with NTM infection (50 patients with HIV/AIDS and 274 patients without HIV/AIDS) were included. The most common etiological agent was M. abscessus (29%), followed by M. paraintracellulare (12%) and M. colombiense (11%). Predominant NTM species were M. avium (26%), M. colombiense (24%), and M. kansasii (18%) in patients with HIV/AIDS and were M. abscessus (32%), M. paraintracellulare (13%), M. fortuitum (10%), and M. intracellulare (10%) in patients without HIV/AIDS. For a CD4+ cell count of <200/μl, the predominant species were M. aviumin the HIV/AIDS group and M. abscessus in the non‐HIV/AIDS group. With respect to radiologic characteristics, different NTM strains were associated with distinct imaging manifestations; for example, M. marseillense, M. kansasii, and M. parasenchytosis were more likely to induce cavities. Imaging cavities, bronchiectasis, and acinar‐like changes were more common in the non‐HIV/AIDS groups.ConclusionsThe infection rates of HIV and NTM in Chongqing are high, while M. abscessus, M. paraintracellulare, and M. colombiense are the main pathogens causing NTM diseases in Chongqing, and NTM strains differed significantly between patients with and without HIV/AIDS. Monitoring these indicators can help develop prevention strategies.
Effectiveness of intentional replantation in managing teeth with apical periodontitis: A systematic review
Authors: Plotino Gianluca , Abella Sans Francesc , Bastos Juliana Vilela , Nagendrababu Venkateshbabu 
Published: March 2022

AbstractBackgroundIntentional replantation (IR) to treat disease of endodontic origin remains controversial. While IR has been advocated by some clinicians as another valid treatment option, others consider it as a treatment procedure of last resort.ObjectiveTo systematically review and critically evaluate the effectiveness of IR compared with nonsurgical root canal treatment/retreatment or apical surgery in terms of clinical and patient‐related outcomes in managing permanent teeth with apical periodontitis (AP).MethodsA literature search of five databases (PubMed, Embase, Scopus, Web of Science and Cochrane Central register of Controlled Trials), and the grey literature (Networked Digital Library of Theses and Dissertations, Open Access Theses and Dissertations, DART‐Europe E‐theses Portal, British Library E‐Theses Online Service), from inception to November 2021, was conducted. Randomised clinical trials, comparative clinical trials (CCTs), nonrandomised, retrospective, and prospective comparative cohort and case–control two arm studies which evaluated clinical and/or patient‐related outcomes of permanent teeth with AP treated with IR compared with nonsurgical root canal treatment/retreatment or apical surgery were identified. The quality of the studies was appraised using the Cochrane risk of bias tool for randomized trials (RoB 2.0), the Robins‐I for nonrandomized controlled clinical trials and the Newcastle‐Ottawa scale for observational studies. Two independent reviewers were involved in the literature selection, performed the data extraction and the appraisal of the studies identified; disagreements were resolved in conjunction with a third reviewer.ResultsNo comparative study was identified from the literature search. Four longitudinal studies (one prospective and three retrospective) were identified during the screening of titles and abstracts but were excluded after reading the full text, because only IR was evaluated (single arm studies).DiscussionThe available evidence on IR is mainly based on observational studies, which reported high overall mid‐ to long‐term survival, and low complication rates. The results suggest that IR may represent an alternative treatment procedure to solve problems of endodontic origin. However, in the absence of high‐quality evidence from CCTs, clinical decision‐making should be on a case‐by‐case basis and in accordance with the clinician's experience and the patient's preference.ConclusionClinical studies showed that IR may be a treatment modality to manage problems of endodontic origin. However, clinical trials comparing the effectiveness of IR with nonsurgical root canal treatment/retreatment or apical surgery are still required given the paucity of evidence.
Mental health nurses perceptions of missed nursing care in acute inpatient units: A multi‐method approach
Authors: Joseph Bindu , Plummer Virginia , Cross Wendy 
Published: March 2022

AbstractNurses have key roles in caring for hospitalized patients. Missed nursing care can lead to adverse outcomes, from minor discomfort to patient death. Mental health nurses have a significant role in advancing knowledge and practice due to missed, delayed, or unfinished nursing care. They are identifying, escalating, and managing warning signs of mental and physical health deterioration where the risk to patients is high in terms of compromised care quality and neglect and the evidence is scant. This study aimed to examine mental health nurses’ perceptions of missed nursing care in acute mental health inpatient units in an Australian regional health service. A cross‐sectional survey was undertaken using a modified Kalisch Phelan MISSCARE questionnaire and a qualitative content analysis was undertaken for narrative responses. Of 70 participants, the majority were aged 30–44 years, with >5 years of experience. The results indicated that care planning, safety audits, communication, and assessment of oral intake were perceived as care most frequently missed. Factors contributing to missed care need urgent exploration to ensure timely reduction of patient risk and enhancements to safe quality care.
Bacterial mandelic acid degradation pathway and its application in biotechnology
Authors: Wang Qingzhuo , Geng Shanshan , Wang Lingru , Wen Zhiqiang , Sun Xiaoman , Huang He 
Published: March 2022

AbstractMandelic acid and its derivatives are an important class of chemical synthetic blocks, which is widely used in drug synthesis and stereochemistry research. In nature, mandelic acid degradation pathway has been widely identified and analysed as a representative pathway of aromatic compounds degradation. The most studied mandelic acid degradation pathway from Pseudomonas putida consists of mandelate racemase, S-mandelate dehydrogenase, benzoylformate decarboxylase, benzaldehyde dehydrogenase and downstream benzoic acid degradation pathways. Because of the ability to catalyse various reactions of aromatic substrates, pathway enzymes have been widely used in biocatalysis, kinetic resolution, chiral compounds synthesis or construction of new metabolic pathways. In this paper, the physiological significance and the existing range of the mandelic acid degradation pathway were introduced first. Then each of the enzymes in the pathway is reviewed one by one, including the researches on enzymatic properties and the applications in biotechnology as well as efforts that have been made to modify the substrate specificity or improving catalytic activity by enzyme engineering to adapt different applications. The composition of the important metabolic pathway of bacterial mandelic acid degradation pathway as well as the researches and applications of pathway enzymes is summarized in this review for the first time.
The jasmonate‐induced bHLH gene SlJIG functions in terpene biosynthesis and resistance to insects and fungus
Authors: Cao Yunyun , Liu Lun , Ma Kangsheng , Wang Wenjing , Lv Hongmei , Gao Ming , Wang Xinman , Zhang Xichun , Ren Shuxin , Zhang Na , Guo Yang‐Dong 
Published: March 2022

AbstractJasmonic acid (JA) is a key regulator of plant defense responses. Although the transcription factor MYC2, the master regulator of the JA signaling pathway, orchestrates a hierarchical transcriptional cascade that regulates the JA responses, only a few transcriptional regulators involved in this cascade have been described. Here, we identified the basic helix‐loop‐helix (bHLH) transcription factor gene in tomato (Solanum lycopersicum), METHYL JASMONATE (MeJA)‐INDUCED GENE (SlJIG), the expression of which was strongly induced by MeJA treatment. Genetic and molecular biology experiments revealed that SlJIG is a direct target of MYC2. SlJIG knockout plants generated by gene editing had lower terpene contents than the wild type from the lower expression of TERPENE SYNTHASE (TPS) genes, rendering them more appealing to cotton bollworm (Helicoverpa armigera). Moreover, SlJIG knockouts exhibited weaker JA‐mediated induction of TPSs, suggesting that SlJIG may participate in JA‐induced terpene biosynthesis. Knocking out SlJIG also resulted in attenuated expression of JA‐responsive defense genes, which may contribute to the observed lower resistance to cotton bollworm and to the fungus Botrytis cinerea. We conclude that SlJIG is a direct target of MYC2, forms a MYC2‐SlJIG module, and functions in terpene biosynthesis and resistance against cotton bollworm and B. cinerea.
Migrant diversity and team performance in a high‐skilled labour market
Authors: Addesa Francesco , Pazzona Matteo , Rossi Giambattista 
Published: March 2022

AbstractFrom a theoretical point of view, the link between workplace diversity and performance in a high‐skilled context is ambiguous. Likewise, empirical research at the firm or plant level finds inconclusive and context‐ specific results. Using a detailed database that covers all the 3,999 matches played by Italian Serie A teams (firms) over a 10‐season period, our results reveal a substantial and robust negative effect of fractionalization on performance, whereas no effect is found for polarization. This article also highlights how the negative effect of fractionalization depends on the nature of the tasks to be completed, the wealth of the teams and the level of workers' experience. This work reveals some myopia in hiring practices and suggests that firms should make better decisions in choosing the optimal mix of workers.
Rosette‐forming glioneuronal tumours are midline, FGFR1‐mutated tumours
Authors: Appay Romain , Bielle Franck , Sievers Philipp , Barets Doriane , Fina Frédéric , Boutonnat Jean , Adam Clovis , Gauchotte Guillaume , Godfraind Catherine , Lhermitte Benoît , Maurage Claude‐Alain , Meyronet David , Mokhtari Karima , Rousseau Audrey , Tauziède‐Espariat Arnault , Tortel Marie‐Claire , Uro‐Coste Emmanuelle , Burel‐Vandenbos Fanny , Chotard Guillaume , Pesce Florian , Varlet Pascale , Colin Carole , Figarella‐Branger Dominique 
Published: March 2022

AbstractAimRosette‐forming glioneuronal tumour (RGNT) is a rare central nervous system (CNS) World Health Organization (WHO) grade 1 brain neoplasm. According to the WHO 2021, essential diagnostic criteria are a ‘biphasic histomorphology with neurocytic and a glial component, and uniform neurocytes forming rosettes and/or perivascular pseudorosettes associated with synaptophysin expression’ and/or DNA methylation profile of RGNT whereas ‘FGFR1 mutation with co‐occurring PIK3CA and/or NF1 mutation’ are desirable criteria.Material and methodsWe report a series of 46 cases fulfilling the essential pathological diagnostic criteria for RGNT. FGFR1 and PIK3CA hotspot mutations were searched for by multiplexed digital PCR in all cases, whereas DNA methylation profiling and/or PIK3R1 and NF1 alterations were analysed in a subset of cases.ResultsThree groups were observed. The first one included 21 intracranial midline tumours demonstrating FGFR1 mutation associated with PIK3CA or PIK3R1 (n = 19) or NF1 (n = 1) or PIK3CA and NF1 (n = 1) mutation. By DNA methylation profiling, eight cases were classified as RGNT (they demonstrated FGFR1 and PIK3CA or PIK3R1 mutations). Group 2 comprised 11 cases associated with one single FGFR1 mutation. Group 3 included six cases classified as low‐grade glioma (LGG) other than RGNT (one‐sixth showed FGFR1 mutation and one a FGFR1 and NF1 mutation) and eight cases without FGFR1 mutation. Groups 2 and 3 were enriched in lateral and spinal cases.ConclusionsWe suggest adding FGFR1 mutation and intracranial midline location as essential diagnostic criteria. When DNA methylation profiling is not available, a RGNT diagnosis remains certain in cases demonstrating characteristic pathological features and FGFR1 mutation associated with either PIK3CA or PIK3R1 mutation.
Macroevolutionary dynamics in the transition of angiosperms to aquatic environments
Authors: Meseguer Andrea S. , Carrillo Rubén , Graham Sean W. , Sanmartín Isabel 
Published: March 2022

SummaryAngiosperm lineages in aquatic environments are characterized by high structural and functional diversity, and wide distributions. A long‐standing evolutionary riddle is what processes have caused the relatively low diversity of aquatic angiosperms compared to their terrestrial relatives.We use diversification and ancestral reconstruction models with a comprehensive > 10 000 genus angiosperm phylogeny to elucidate the macroevolutionary dynamics associated with transitions of terrestrial plants to water.Our study reveals that net diversification rates are significantly lower in aquatic than in terrestrial angiosperms due to lower speciation and higher extinction. Shifts from land to water started early in angiosperm evolution, but most events were concentrated during the lastc. 25 million years. Reversals to a terrestrial habitat started only 40 million years ago, but occurred at much higher rates. Within aquatic angiosperms, the estimated pattern is one of gradual accumulation of lineages, and relatively low and constant diversification rates throughout the Cenozoic.Low diversification rates, together with infrequent water transitions, account for the low diversity of aquatic angiosperms today. The stressful conditions and small global surface of the aquatic habitat available for angiosperms are hypothesized to explain this pattern.
Maternal long working hours and offspring's weight‐related outcomes: A systematic review and meta‐analysis
Authors: Lou Yiling , Zhu Yi , You Qiqi , Jiang Qingqing , Meng Xin , Di Hongkun , Xu Hongbin , Gan Yong , Lu Zuxun , Cao Shiyi 
Published: March 2022

SummaryIt is unclear whether maternal working time has an impact on offspring's weight‐related outcomes especially obesity; the objective of this study is to conduct the first meta‐analysis to focus on this topic. We searched PubMed, Ovid, and Web of Science databases through August 2021. A random‐effect model was used to assess the pooled odds ratios (ORs) and regression coefficients (β) with their corresponding 95% confidence intervals (95% CIs). Subgroup analyses were conducted to explore sources of heterogeneity. Publication bias was evaluated by the Egger's tests. Twenty‐two observational studies were included with a total of 191,420 participants. Compared with children whose mothers worked less than 35 h/week, we found that children whose mothers worked more than 35 to 40 h/week had a 2.24‐fold increased risk of childhood overweight/obesity (OR = 2.24, 95% CI: 1.61–3.11). An increment of 10 h/week in maternal working was associated with an approximately 1.0 percentage points in the probability of childhood overweight/obesity (β = 0.008, 95% CI: 0.004–0.012). The pooled OR also indicated a similar result (OR = 1.09, 95% CI: 1.04–1.15). In addition, an increment of 10 h/week in maternal working was associated with 0.029 units increase in offspring's BMI z score (β = 0.029, 95% CI: 0.016–0.042). Maternal long working hours is a potential risk factor for offspring's weight‐related outcomes. Measures should be taken to protect the work welfare of females, thus facilitating the positive interaction of individual–family–society.