bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular signatures in diabetic foot ulcer by integrated gene expression profiling via bioinformatics analysis
Authors: Shetty K. Shwetha , Gollapalli Pavan , Shetty Abhijith , Kumari N. Suchetha , Shetty Praveenkumar , Prakash Patil  
Published: September 2022

Introduction and Aim: Diabetic foot ulcers (DFUs) are a common and debilitating diabetic consequence leading to lower-limb amputations, long-term disability, and reduced lifespan. There is a lack of clinical diagnosis expertise because of no adequate diagnostic signs for DFU. As a result, the current research aims to find out how differently expressed genes (DEGs) affect the DFU.
Materials and Methods: Bioinformatics analysis was used to evaluate DEGs using the GSE132187 dataset of the NCBI-GEO database, which contained samples from three hyperglycemic and three normoglycemic macrophage-like cell lines. Following the discovery of DEGs, Gene Ontology (GO) and KEGG pathway enrichment analysis were used to investigate how genes are classified into preset bins based on their functional properties. To discover hub DEGs in DFU, a protein-protein interaction (PPI) network was built and five topological parameters such as degree, stress, Closeness centrality, betweenness centrality, and radiality were evaluated.
Results: We found 547 DEGs using the GSE132187 dataset, comprising 79 upregulated DEGs and 468 downregulated DEGs. There were 434 nodes and 1724 edges in the PPI network. The giant network uncovered six modules that are significantly enriched in biological processes like positive JNK cascade regulation, positive interferon-gamma production regulation, negative cell proliferation regulation, cellular response to zinc ion, cellular response to lipopolysaccharide, wound healing, and inflammatory response.
Conclusion: Bioinformatics analysis revealed the major differentially expressed hub-genes implicated in DFUs. These findings suggested that these genes could be used as a DFU prognostic, diagnostic, or therapeutic targets.
Micro-macroscopic anatomy of the lymphatic vessels and lymph nodes that form the parietal lymphatic pathways of the human thoracic cavity
Authors: Omurbaev Almaz , Satylganov Ishenbek , Gayvoronskaya Yuliya , Abirova Rakhat , Tokhtyev Ilkhamzhan , Moldotasheva Gulnara 
Published: September 2022

Introduction: Many pathological processes such as infections, intoxications, and malignant tumors were spread through the lymphatic vessels of the thoracic cavity. In the present study, we investigated the anatomy of the lymphatic vessels and lymph nodes of the thoracic cavity in humans.
Materials and methods: The examination was performed on 60 cadavers of fetuses (25), newborn children (14), children (11), and adults (10). Lymphatic vessels of the rib periosteum, costovertebral, costotransverse, and sternocostal joints, as well as parietal lymphatic vessels and lymph nodes of the thoracic cavity were studied. A comparative study of arterial, venous, and lymphatic vessels was carried out.
Results: The parietal lymph nodes of the thoracic cavity include parasternal (localized along the course of the thoracic arteries and veins), paramammary (located near the lateral edge of the pectoralis major muscle), intercostal, paravertebral, and upper diaphragm. The efferent lymphatic vessels of the periosteum and perichondrium of the first three ribs go to the intercostal lymph nodes, to the parasternal, paravertebral and diaphragmatic lymph nodes.
Conclusion: The presence of intercalated lymph nodes on the thoracic cavity is characteristic of the entire lymphatic system and should be considered in the pathology of the thoracic cavity.
Characterization of antioxidant, anti-cancer, and immunomodulatory functions of partially purified garlic (Allium sativum L.) lectin
Authors: Shruthishree D. Padiyappa  , Hemavathi Avalappa  , Yeldur P. Venkatesh  , Nagaraj Parisara  , B. T. Prabhakar  , Pramod.S.N.  
Published: September 2022

Introduction and Aim: The metabolic and oxidative stress induces highly reactive free radicals that are known to harm normal physiology and play a role in the development of cancer. Elevated levels of these free radicals contribute to excessive neovascularization leading to angiogenesis mediated cancer progression. Targeting these free radicals through dietary source is important strategy in regulation of cancer. Allium sativum L. (AsL) garlic has important multi pharmacological properties. On the other hand, dietary lectins are proven to be the best anti-cancer molecules. The study presents investigation that focus to assess the antioxidant, immunomodulatory and anticancer activities of partially purified garlic lectin (PPAsL).
Materials and Methods: Fresh garlic bulbs were processed and evaluated for lectin induced HA activity. Further the garlic lectins (AsL) were partially purified by ammonium sulphate precipitation and dialysis and analyzed through SDS-PAGE. Further lectins were characterized by producing Anti-AsL polyclonal antibodies and purification by affinity chromatography. Pharmacological evaluations of the lectins were assessed through antioxidant, anti-proliferative and antiangiogenic mediated anti-cancer activity.
Results: Lectin positive activity was confirmed by HA activity and partial purification lectin identified ?12kDa protein having Glc/Man glycan specificity. The polyclonal antibodies raised against PPAsL, confirmed that it has potent immunogen. Pharmacological evaluation confirmed that PPAsL has potent antioxidant, antiangiogenic and antiproliferative effect both in-vitro and in-vivo.
Conclusion: PPAsL is potent antioxidant, anti-proliferative and anti-cancer molecule. The dietary recommendation of the garlic lectin is an important therapeutic strategy against the cancer.
Assessing the effectiveness of an educational intervention on knowledge of Infection control practices including Covid-19 among the health care workers
Authors: Chaturvedi Priyanka , Pandey Anita , Anubhuti  
Published: September 2022

Background: Healthcare workers (HCWs) are always at a risk of contracting infection due to their frequent exposure to infected individuals. Knowledge regarding various infection control practices especially in this pandemic era is mandatory to safeguard the HCWs.
Objective: An interventional study was carried out to assess the level of knowledge of Infection control practices and standard precautions with special reference to COVID-19among the health care workers of a tertiary care teaching Hospital.
Materials and methods: A total of 202, undergraduate students (UGs), postgraduate students (PGs), and non-teaching staff (NTS) participated in this study. A pre-test self-structured questionnaire regarding infection control practices and standard precautions with special reference to COVID-19 was distributed to all the participants. The study participants were then trained by the faculty of Microbiology and infection control team vigorously. The post-training questionnaire was subsequently given to the same group of subjects. The data from before and after training was evaluated and compared.
Result: On post-training evaluation after the intervention, there was a significant increase in knowledge of various infection control practices among HCWs, as seen by comparing the results of the post-test questionnaire to its pre-test counterpart, because the HCWs' doubts were cleared in the education sessions.
Conclusion: The knowledge regarding the various infection control practices among the HCWs is short-lived and a significant increase was observed on post-training. The health care settings should make a policy to carry out mandatory rotational repeated training by the Infection control team for all the groups of HCWs for better compliance.
A need to reconsider the rehabilitation protocol in patients with idiopathic Parkinson’s disease: Review analysis
Authors: Deepa S.  , Abathsagayam Kumaresan , Prathap Suganthirababu  , Ramana K.  , Surya Vishnuram  , Vignesh Srinivasan  
Published: September 2022

Idiopathic Parkinson’s disease is the second most debilitating and progressive neurodegenerative disease affecting the functional activities in day-to-day life. The motor and non-motor symptoms have shown to be a huge functional loss for the subject which has led to compromise their independence. There are varieties of treatment programs proposed as pharmacological, surgical, rehabilitation, allied therapies but none have proven to be the disease modifying treatments in managing the symptoms of Parkinson’s disease patients. Research has shown that discontinuity in the treatment and diminished effects of treatments have drained care givers physically, emotionally, and financially. In this study we explore the available physiotherapy treatment strategies highlighting the research gaps in articles (n=36). The articles were taken from the databases such as PubMed, Science Direct and Google Scholar by considering the inclusion and exclusion criteria. Though the present research has shown to be significant in improving the motor and non-motor symptoms there are still unanswered questions on the rehabilitation protocols whether they can modify the disease and improve the quality of life among Parkinson’s disease in long term. Exercise have proven to be beneficial, cost effective and low risk which improves the overall health and independence of the patient, however, the mechanism involved are less understood.
Barriers related to self-care management among people with diabetes mellitus- A narrative review
Authors: Nebhinani Mamta , Avasthi Rishi Dutt , Meena Meenakshi , Parihar Megha , Sharma Megha , Nagar Monika , Neha  , Nisha  
Published: September 2022

Diabetes is a challenging disease that is considered to be hard to live with as it encompasses a lot of restrictions, lifestyle and behavioural modifications. Self-care management behaviors are very much essential to control glycaemic values and future complications. Although an import aspect leading to positive health outcomes among diabetic patients, diabetes self-care management is usually is a complex process. This narrative review summates barriers related to self-care management among people with diabetes. The literature was searched through databases like PubMed and google scholar with help of keywords and MeSH terminologies. Furthermore, selected articles reference list was also screened. It is concluded that self-care management in diabetes mellitus is often surrounded by many barriers. Deficiency of environmental resources and assisted strategies, poor awareness regarding self-care skills, lack of motivation and financial constraints are the major barriers faced by people with diabetes mellitus. Endeavour to withdraw barriers are prime in aiding people living with diabetes which will help to improve their quality of life and to attain positive results.
Peningkatan Ketrampilan Menulis Cerita Fantasi Melalui Strategi Pembelajaran Menyenangkan (Joyfull Learning) pada Siswa Kelas VII MTs Salafiyah Siman Sekaran Lamongan Tahun Ajaran 2019/2020
Authors: Ulumuddin Muhammad Ihya , Setiawan Arif 
Published: September 2022

Penelitian ini bertujuan untuk mendeskripsikan kemampuan menulis cerita fantasi siswa kelas VII MTs Salafiyah Siman Sekaran Lamongan. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kuantitatif. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK). Sumber data dalam penelitian ini adalah siswa kelas VII MTs Salafiyah Siman Sekaran Lamongan. Data dalam penelitian ini berupa kemampuan menulis cerita fantasi siswa kelas VII MTs Salafiyah Siman Sekaran Lamongan. Instrumen yang digunakan untuk mengumpulkan data dalam penelitian ini yaitu instrumen tes menulis. Siswa diberi kebebasan untuk menulis cerita fantasi sesuai dengan kreativitas masing-masing. Berdasarkan hasil penelitian, dapat dijelaskan bahwa siswa yang mencapai ketuntasan pada prasiklus sebanyak 6 siswa (40%), siklus 1 sebanyak 11 siswa (55%), dan siklus 2 sebanyak 19 siswa (82%).
Trajektori Perempuan dalam Novel Mentari Nur Syamsiah Bersinar
Authors: Saputra Ardi Wina , Tjahjono Tengsoe 
Published: September 2022

Tujuan penelitian ini adalah mengetahui wujud trajektori tokoh perempuan dalam novel Mentari Nur Syamsiah Bersinar karya Agnes Adhani. Pendekatan penelitian ini adalah pendekatan sosiologis. Sumber data yang digunakan dalam penelitian ini adalah novel Mentari Nur Syamsiah Bersinar karya Agnes Adhani Analisis data dilakukan adalah (1) analisis struktural aktansial, kemudian (2) analisis sosial Pierre Bourdieu ditinjau dari aspek kekerasan simbolik, dominasi maskulin, habitus, modal, ranah, dan praktik sosial, serta (3) memasukkan unsur gastronomi pada setiap aspek analisis. Hasil penelitian ini adalah trajektori tokoh utama dan usahanya untuk melepaskan diri dari dominasi maskulin.
STRATEGI PENINGKATAN SARANA DAN PRASARANA MIN DENPASAR
Authors: JAMALLUDIN JAMALLUDIN 
Published: September 2022

This study aims to improve the facilities and infrastructure of MIN Denpasar with several strategies used. The approach used in this study is a qualitative approach using descriptive methods. The data obtained from the respondents are used as is. Analysis of the data obtained from the research is analyzed using certain procedures so as to produce findings. The place for this research is Madrasah Ibtidaiyah Negeri Denpasar, Bali. The results of this study obtained educational facilities, namely equipment that is directly used for the educational process, such as tables, chairs, classes, and teaching media. Educational infrastructure is facilities that indirectly support the educational process, such as yards, gardens, and parks. MIN Denpasar at this time, it seems that the overall facilities and infrastructure owned have not met the minimum standards. In fulfilling the minimum standard of facilities and infrastructure only, efforts are needed that can produce or recommend that the facilities and infrastructure of MIN Denpasar, especially above the minimum standard.
ABSTRAKPenelitian ini bertujuan untuk meningkatkan sarana dan prasarana MIN Denpasar dengan beberapa strategi yang digunakan. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kualitatif dengan menggunakan metode deskriptif. Data yang diperoleh dari responden digunakan sebagaimana adanya. Analisa data yang didapat dari penelitian dianalisa dengan menggunakan prosedur tertentu sehingga menghasilkan temuan. Tempat pelaksanaan penelitian ini adalah di Madrasah Ibtidaiyah Negeri Denpasar, Bali. Hasil penelitian ini didapatkan Sarana pendidikan, yaitu perlengkapan yang secara langsung dipergunakan untuk proses pendidikan, seperti meja, kursi, kelas, dan media pengajaran. Prasarana pendidikan ialah fasilitas yang secara tidak langsung menunjang jalannya proses pendidikan, seperi halaman, kebun, dan taman. MIN Denpasar saat ini, tampaknya secara keseluruhan sarana maupun prasarana yang dimiliki belum memenuhi standar minimal. Dalam pemenuhan standar minimal sarana dan prasarana saja, sangat diperlukan upaya–upaya yang dapat menghasilkan ataupun merekomendasikan agar kiranya sarana dan prasarana MIN Denpasar apalagi di atas standar minimal.
PENGARUH FASILITAS BELAJAR, KOMPETENSI, DAN KINERJA GURU TERHADAP MUTU PENDIDIKAN DI SMK KABUPATEN BOGOR
Authors: MANTIKA SUCI PUTRI , PURWANTO ANIM 
Published: September 2022

The purpose of this research is to determine, identify, and assess the influence of independent factors such as learning facilities, competency, and teacher performance on the dependent variable, namely education quality in Bogor Regency Vocational Schools. This study employed a survey method with a quantitative approach. The target population is 133 instructors, while the study sample is 100 teachers after applying the Slovin formula. A questionnaire was utilized to collect data for this study. The data was processed using Structural Equation Modeling Partial Least Squares (SEM-PLS). SmartPLS 3.0 is the program used to process the data. In this study, assessing the data comprises testing the outer model, the inner model, and the hypothesis. The coefficient of determination (R Square) was found to be 42,4 percent. The remaining 57,6 percent is explained by factors other than the study model. As a result of these findings, this study model may be deemed to have a high goodness of fit. In evaluating the hypothesis, learning facilities have a direct positive influence on educational quality. Teacher competency has a direct beneficial impact on educational quality. Meanwhile, teacher performance has little direct impact on educational quality. This teacher performance characteristic requires careful study so that teacher can deliver the best possible performance in the classroom.
ABSTRAKPenelitian ini bertujuan untuk mengetahui, mengidentifikasi dan menganalisis pengaruh variabel bebas yang terdiri dari fasilitas belajar, kompetensi dan kinerja guru terhadap variabel terikat yaitu mutu pendidikan di SMK Kabupaten Bogor. Metode yang digunakan dalam penelitian ini adalah metode survei dengan pendekatan kuantitatif. Populasi target sebanyak 133 guru dan setelah dihitung dengan rumus Slovin, diperoleh sampel penelitian sebanyak 100 guru. Pengumpulan data yang digunakan dalam penelitian ini adalah menggunakan kuesioner. Pengolahan data dilakukan dengan Structural Equation Modelling Partial Least Squares (SEM-PLS). Aplikasi yang digunakan untuk mengolah data adalah SmartPLS versi 3.0. Pengujian data dalam penelitian ini meliputi pengujian outer model, pengujian inner model dan pengujian hipotesis. Hasil penelitian menunjukkan bahwa nilai koefisien determinasi (R Square) sebesar 42,4%. Sedangkan sisanya sebesar 57,6% dijelaskan oleh faktor lain yang berada di luar model penelitian ini. Dengan demikian, dari hasil tersebut maka model penelitian ini dapat dinyatakan telah memiliki goodness of fit yang baik. Pada pengujian hipotesis diperoleh, fasilitas belajar berpengaruh langsung positif terhadap mutu pendidikan. Kompetensi guru berpengaruh langsung positif terhadap mutu pendidikan. Sedangkan kinerja guru tidak berpengaruh langsung terhadap mutu pendidikan. Variabel kinerja guru ini perlu mendapat pertimbangan kritis agar guru dapat memberikan kinerja tertinggi di sekolah.
Exploring Men’s Perceptions of Women’s Role in Agriculture: A Qualitative Study of Union Council 79, Multan
Authors: Kausar Shumaila , Butt Muhammad Zeshan , Kousar Naseem , Farooq Muhammad Adeel 
Published: September 2022

In the patriarchal society of Pakistan, women are viewed as inferior to men. This gender prejudice is also evident in the agriculture industry. This study intends to investigate men's perceptions of women's role in agriculture-related activities. Utilizing a qualitative study design, the researcher conducted six focus group discussions and eight in-depth interviews with the men in Multan district, Punjab, thematic analysis was performed on the data in order to deeply comprehend the phenomenon. The bulk of the male population partially recognises women's contributions in the agriculture sector, the study revealed. Most of the population believed that poverty is the primary reason why women work in agriculture. In men’s views, women are weaker than men and, as a result, unable to conduct agriculture-related activities, particularly the activities requiring extra force. Their attitude was strongly patriarchal in that they viewed women as unpaid or low-paid workers. The vast majority of the population recognises that their contribution is of crucial importance to food security. It can be concluded that the majority of male members view women as lesser and weaker workers than males. Men's sexist attitudes toward women demonstrate the urgent need to confront patriarchal society, which not only hinders women's development in the agriculture industry but also affects their productivity and food security.
Rate of Cutting Sebagai Metode untuk Meningkatkan Tempo Adegan pada Dua Puluh Enam Menit Pertama Film Penyalin Cahaya Karya Wregas Bhanuteja
Authors: Prayuda Yohanes Yoga , Risang R.M. Widihasmoro 
Published: September 2022

Editing secara harafiah adalah usaha penyambungan akhir dari sebuah shot dengan awal dari shot berikutnya, dan begitu seterusnya. Pembahasan lebih lanjut dari sekedar menyambung gambar, ternyata selalu menjadi pembahasan yang menarik. Film Penyalin Cahaya yang telah berhasil mendapatkan banyak penghargaan menjadi film yang menarik untuk diulas dari sisi teori editing. Dalam sebuah buku berjudul Cutting Rhythm pembahasan tentang ritme penyambungan dihitung dalam tempo beat per minute (bpm), dimana dianggap normal jika merujuk pada detak jantung manusia normal yaitu 60 - 80bpm. Di atas itu, sensasi ritme cepat dapat dirasakan, dan di bawahnya, sensasi ritme lambatlah yang dirasakan. Salah satu cara editor memanipulasi sensasi tersebut adalah memanfaatkan rate of cutting.
Wawancara: Hanung Bramantyo
Authors: IMAJI Jurnal 
Published: September 2022

Dalam rubrik Jurnal IMAJI Vol. 13 No. 2 kali ini kami menghadirkan wawancara secara mendalam dengan tokoh perfilman nasional yaitu Hanung Bramantyo, beliau merupakan seorang sutradara film seperti Perempuan Berkalung Sorban (2009), Sang Pencerah (2010), Tanda Tanya (2011), Sultan Agung: Tahta, Perjuangan, Cinta (2018) dan yang terbaru dan sedang tayang di bioskop saat ini adalah Satria Dewa: Gatotkaca (2022).
Mari kita simak!
Problematização do cotidiano e a Base Nacional Comum Curricular: relato de experiência em Estatística no contexto do Novo Ensino Médio
Authors: Carius Ana Carolina 
Published: September 2022

Com início de implementação previsto para 2022, o Novo Ensino Médio, amparado pela Base Nacional Comum Curricular, modificou substancialmente o papel da matemática na Educação Básica. Considerando essa importante mudança, este trabalho teve por objetivo realizar uma atividade prática na Unidade Temática Probabilidade e Estatística, a partir de uma situação-problema cotidiana, para uma turma de Ensino Médio de uma escola pública federal situada no estado do Rio de Janeiro. A partir da atividade proposta, o presente trabalho buscou responder à seguinte pergunta de pesquisa: “A problematização do cotidiano em matemática contribui, de forma significativa, para a aprendizagem dos estudantes do Ensino Médio?” Ao final da experiência se concluiu que a relação da matemática com questões inerentes ao cotidiano oportuniza discussões mais amplas e engajadas por parte dos estudantes e, dessa forma, colabora na melhoria da aprendizagem destes indivíduos.
Processos de aquisição da leitura por crianças: relatos de experiências exitosas
Authors: Ferreira Rosana , Bruzi Alessandro Teodoro , Souza Cleverton José Farias de , Ferreira Helena Maria 
Published: September 2022

A aquisição da leitura representa um marco desenvolvimentista e de inclusão social para todas as crianças. As professoras alfabetizadoras são responsáveis por estimular essa aquisição. Nesse sentido, investigamos o processo de aquisição da leitura por crianças. O objetivo desta pesquisa foi analisar experiências exitosas de três professoras egressas do curso de mestrado profissional em Educação de uma instituição federal de ensino superior que promoveram a aquisição da leitura por crianças. Essa análise se justifica pelas possíveis contribuições que a troca de saberes pode incitar para a formação docente. Nossa pesquisa teve uma abordagem qualitativa por meio de Relatos de Experiências das professoras participantes. Foi solicitado às professoras que descrevessem uma experiência exitosa relacionada ao processo de aquisição da leitura. Os resultados foram examinados à luz de teorias de aprendizagem, letramento e alfabetização. Identificou-se que as práticas, além de eficazes, estão previstas na Base Nacional Comum Curricular (BNCC). Conclui-se que a aquisição da leitura por crianças depende da alfabetização associada ao letramento.