bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular detection and identification of phytoplasmas associated with Catharanthus roseus, Pinus eldarica, and Petunia hybrida in southeastern Iran's urban green spaces
Authors: Movahedi‐Parizi Fatemeh , Hosseinipour Akbar , Azadvar Mehdi , Massumi Hossain 
Published: October 2022

AbstractGiven the potential for urban green spaces to provide fresh and healthy environments for humans, exploring the issues that threaten plants in these places is crucial. Phytoplasma‐related symptoms were encountered on some plants in urban green spaces in the province of Kerman, southeastern Iran, between 2017 and 2019. Affected periwinkles and petunias exhibited phytoplasma disease symptoms, including virescence, phyllody, and witches'‐broom. However, ball or disc‐like shoot proliferation symptoms were noticed on the trunks and branches of pine trees. PCR was performed with phytoplasma‐detecting universal primers, targetting and amplifying the 16S rRNA gene, and determining whether phytoplasmas are implicated in the symptomatic plants. The infection of the symptomatic plants was confirmed using nested‐PCR amplification of expected DNA sizes for phytoplasmas. No product, however, was amplified from sampled symptomless plants. The sequencing of nested‐PCR products was performed to obtain sequences encasing the standard F2nR2 fragments. The resulted sequences were submitted to iPhyClassifier, the universal phytoplasma classification platform, for the taxonomic assignment of the found phytoplasmas compared with previously identified ‘Candidatus Phytoplasma’ species, groups, and subgroups. The results revealed that phytoplasma strains related to the species ‘Ca. P. trifolii’ (16SrVI‐A subgroup) infect periwinkles and pines. However, strains from the species ‘Ca. P. aurantifolia’ (16SrII‐D subgroup) and ‘Ca. P. phoenicium’ (16SrIX‐C subgroup) were found in petunias and periwinkles, respectively. To the best of our knowledge, phytoplasmas from the 16SrVI‐A and 16SrII‐D subgroups are the first reported to infect these plants in Kerman province, while a related strain from the subgroup 16SrIX‐C is the first recorded to infect periwinkles in Iran and the second in the world.
Hiriira Spatiotemporalities: Mapping Oromo Women’s Liberation in Post‐Imperial Berlin
Authors: Bass Madeline 
Published: October 2022

AbstractIn September 2020, Oromo women marched through the streets of Berlin, Germany, demanding recognition for their struggle. This protest march, called a Hiriira in the Oromo language, offers a case study into the entanglements between settler colonial Ethiopia, Germany’s post‐empire, and the forces of oppression which link them. This paper uses the spatiotemporal reckonings generated from the Hiriira perspective to understand violence and elucidate the practices of resistance that have emerged despite it. These contrasting ways of viewing space and time are expressed through the tension between imperial spatialising, a way of knowing the world that is imperial and oppressive in nature, and geography guraacha, a Black and Blackened way of knowing space with a particularly Oromo perspective. The result is a type of mapping, tracing the Hiriira route across Berlin while describing the histories that shadow these streets, and the pathways towards liberation that Oromo women are organising.
Editorial: colorectal cancer in elderly‐onset inflammatory bowel disease—what is the risk?
Authors: Weiss Alexandra , Buchner Anna M. 
Published: October 2022

LINKED CONTENTThis article is linked to Everhov et al papers. To view these articles, visit https://doi.org/10.1111/apt.17175 and https://doi.org/10.1111/apt.17229
Letter: fighting the battle but losing the war—inflammatory bowel disease and venous thromboembolism. Authors' reply
Authors: Lee Kate E. , Faye Adam S. 
Published: October 2022

LINKED CONTENTThis article is linked to Faye et al papers. To view these articles, visit https://doi.org/10.1111/apt.17162 and https://doi.org/10.1111/apt.17203
Orexin‐A and orexin‐B are differently localized in the pars nervosa and pars distalis of the white‐spotted conger and Japanese eel pituitaries
Authors: Suzuki Hirohumi , Yamamoto Toshiharu 
Published: October 2022

AbstractThe distribution of orexin‐A and orexin‐B immunoreactivity was examined in the pituitaries of the white‐spotted conger (Conger myriaster) and the Japanese eel (Anguilla japonica) using immunohistochemical techniques. Orexin‐A‐immunoreactive puncta were dispersed in the pars nervosa of the neurointermediate lobe, and a part of these puncta were immuno‐positive for galanin. In contrast, orexin‐B immunoreactive cells were observed in the proximal part of the pars distalis, and these cells were immuno‐positive for luteinizing hormone. Considering the present results and previous findings, orexin‐A and orexin‐B may modulate the secretion of α‐melanocyte‐stimulating hormone and growth hormone, respectively, and participate in the regulation of energy homeostasis.
A comprehensive study of immune function and immunophenotyping of white blood cells from β‐thalassaemia/HbE patients on hydroxyurea supports the safety of the drug
Authors: Siriworadetkun Sirikwan , Thiengtavor Chayada , Thubthed Rattanawan , Paiboonsukwong Kittiphong , Fucharoen Suthat , Pattanapanyasat Kovit , Vadolas Jim , Svasti Saovaros , Chaichompoo Pornthip 
Published: October 2022

SUMMARYHydroxyurea (HU) (hydroxycarbamide) is used as a therapeutic option in β‐thalassaemia to increase fetal haemoglobin, which results in a reduced requirement for blood transfusion. However, a potential serious adverse effect of HU is neutropenia. Abnormal neutrophil maturation and function in β‐thalassaemia/HbE patients are well documented. This raises questions about the effect of the drug with regards to the immune response these patients. This study investigated the effects of HU treatment on both innate and adaptive immunity in a cross‐sectional study of 28 β‐thalassaemia/HbE patients who had received HU treatment (BE+HU) as compared with 22 β‐thalassaemia/HbE patients who had not received HU (BE‐HU) and 26 normal subjects. The expression of PU.1 and C/EBPβ, transcription factors, which are associated with neutrophil maturation, was significantly reduced in BE+HU patients as compared with BE‐HU patients and normal subjects. Interestingly, C3bR expression on neutrophils and their oxidative burst activity in BE+HU were restored to close to normal levels when compared with BE‐HU. There was no observed effect of HU on monocytes, myeloid derived suppressor cells (both granulocytic and monocytic subsets), CD4+T cells, CD8+T cells, complement levels and serum immunoglobulin levels in this study. The full immunophenotyping analysis in this study indicates that HU therapy in β‐thalassaemia/HbE patients does not significantly compromise the immune response.
The dark side of nostalgia: Yearning for the past fosters bribe‐taking
Authors: Li Chao , Dang Jianning , Liu Li , Wei Cong , Liang Yuan 
Published: October 2022

AbstractPast work has demonstrated the psychological benefits of nostalgia; however, little is known about its ‘dark side’. Considering both the sociality of nostalgia and the relational nature of bribery, we proposed that nostalgia would bolster social connectedness, which, in turn, would promote bribe‐taking. We conducted four experiments (N = 887 online and laboratory participants) to test this assumption. Experimentally induced nostalgia boosted the willingness to take a bribe across different scenarios (Experiments 1 and 2) and facilitated bribe‐taking behaviour (Experiment 3); the increased social connectedness accounted for these effects (Experiments 2 and 3). Furthermore, the positive effect of social connectedness on bribe‐taking was salient, especially when bribe‐taking was framed as a way of establishing social relationships (Experiment 4). The findings not only broaden our understanding of nostalgia and bribe‐taking but also provide practical implications for anti‐bribery initiatives.
A generalised approach to the study and understanding of adaptive evolution
Authors: Edelaar Pim , Otsuka Jun , Luque Victor J. 
Published: October 2022

ABSTRACTEvolutionary theory has made large impacts on our understanding and management of the world, in part because it has been able to incorporate new data and new insights successfully. Nonetheless, there is currently a tension between certain biological phenomena and mainstream evolutionary theory. For example, how does the inheritance of molecular epigenetic changes fit into mainstream evolutionary theory? Is niche construction an evolutionary process? Is local adaptation via habitat choice also adaptive evolution? These examples suggest there is scope (and perhaps even a need) to broaden our views on evolution. We identify three aspects whose incorporation into a single framework would enable a more generalised approach to the understanding and study of adaptive evolution: (i) a broadened view of extended phenotypes; (ii) that traits can respond to each other; and (iii) that inheritance can be non‐genetic. We use causal modelling to integrate these three aspects with established views on the variables and mechanisms that drive and allow for adaptive evolution. Our causal model identifies natural selection and non‐genetic inheritance of adaptive parental responses as two complementary yet distinct and independent drivers of adaptive evolution. Both drivers are compatible with the Price equation; specifically, non‐genetic inheritance of parental responses is captured by an often‐neglected component of the Price equation. Our causal model is general and simplified, but can be adjusted flexibly in terms of variables and causal connections, depending on the research question and/or biological system. By revisiting the three examples given above, we show how to use it as a heuristic tool to clarify conceptual issues and to help design empirical research. In contrast to a gene‐centric view defining evolution only in terms of genetic change, our generalised approach allows us to see evolution as a change in the whole causal structure, consisting not just of genetic but also of phenotypic and environmental variables.
Phase I trial of myeloablative conditioning with 3‐day total marrow and lymphoid irradiation for leukemia
Authors: Ogawa Hiroaki , Konishi Tatsuya , Najima Yuho , Kito Satoshi , Hashimoto Shimpei , Kato Chika , Sakai Satoshi , Kanbara Yasuhiro , Atsuta Yuya , Konuma Ryosuke , Wada Atsushi , Murakami Daisuke , Nakasima Shiori , Uchibori Yusuke , Onai Daishi , Hamamura Atsushi , Nishijima Akihiko , Shingai Naoki , Toya Takashi , Shimizu Hiroaki , Kobayashi Takeshi , Ohashi Kazuteru , Doki Noriko , Murofushi Keiko Nemoto 
Published: October 2022

AbstractThis prospective phase I trial aimed to determine the recommended dose of 3‐day total marrow and lymphoid irradiation (TMLI) for a myeloablative conditioning regimen by increasing the dose per fraction. The primary end‐point of this single‐institution dose escalation study was the recommended TMLI dose based on the frequency of dose‐limiting toxicity (DLT) ≤100 days posthematopoietic stem cell transplantation (HSCT); a 3 + 3 design was used to evaluate the safety of TMLI. Three dose levels of TMLI (14/16/18 Gy in six fractions over 3 days) were set. The treatment protocol began at 14 Gy. Dose‐limiting toxicities were defined as grade 3 or 4 nonhematological toxicities. Nine patients, with a median age of 42 years (range, 35–48), eight with acute lymphoblastic leukemia and one with chronic myeloblastic leukemia, received TMLI followed by unrelated bone marrow transplant. The median follow‐up period after HSCT was 575 days (range, 253–1037). Three patients were enrolled for each dose level. No patient showed DLT within 100 days of HSCT. The recommended dose of 3‐day TMLI was 18 Gy in six fractions. All patients achieved neutrophil engraftment at a median of 19 days (range, 14–25). One‐year overall and disease‐free survival rates were 83.3% and 57.1%, respectively. Three patients experienced relapse, and no nonrelapse mortality was documented during the observation period. One patient died due to disease relapse 306 days post‐HSCT. The recommended dose of 3‐day TMLI was 18 Gy in six fractions. The efficacy evaluation of this regimen is currently being planned in a phase II study.
Stabilization of estrogen receptor α by USP37 contributes to the progression of breast cancer
Authors: Cao Jing , Wang Xiaobo , Wang Shouman , Chen Zihua , Tang Jianing 
Published: October 2022

AbstractBreast cancer is a major cause of cancer‐related morbidity and mortality in women. Estrogen receptor‐positive breast cancer accounts for roughly 70%‐80% of breast tumors, and estrogen receptor alpha (ERα) has been considered as a key driver in promoting breast cancer progression. In the present study, we identified USP37 as a novel modulator in modulating ERα ubiquitination and stability. The expression of USP37 was upregulated in ERα‐positive breast cancer and correlated with ERα protein level. High expression of USP37 was associated with unfavorable prognosis. USP37 depletion resulted in significantly decreased ERα protein level, ERα target genes expression as well as the estrogen response element activity in breast cancer cells. Further mechanistic study revealed the interaction between USP37 and ERα: USP37 regulated ERα signaling through modulating protein stability instead of gene expression, in which it stabilized ERα protein via inhibiting the K48‐specific polyubiquitination process. Additionally, USP37 depletion led to growth inhibition and cell cycle arrest of ERα‐positive breast cancer cells, which could be further rescued by ERα overexpression. Overall, our study proposed a novel post‐translational mechanism of ERα in promoting breast cancer progression. Targeting USP37 may be proved to be a promising strategy for patients with ERα‐positive breast cancer.
Oral function of implant‐assisted removable partial dentures with magnetic attachments using short implants: A prospective study
Authors: Watanabe Masataka , Kanazawa Manabu , Sato Daisuke , Uehara Yoko , Miyayasu Anna , Iwaki Maiko , Komagamine Yuriko , Naing Sai Tun , Katheng Awutsadaporn , Kusumoto Yuriko , Abe Yuka , Baba Kazuyoshi , Minakuchi Shunsuke 
Published: October 2022

AbstractObjectivesThis prospective study aimed to compare the oral functions of removable partial dentures (RPDs) with those of implant‐assisted removable partial dentures (IARPDs) with short implants and magnetic attachments in patients with mandibular Kennedy class I and II.Material and MethodsThirty participants with mandibular Kennedy class I or II and at least three distal missing teeth were recruited. Oral functions, including mixing ability, comminuting ability, maximum bite force, and occlusal contact area, were assessed for RPDs (stage 0), IARPDs with healing caps (stage 1), and IARPDs with magnetic attachments (stage 2). The implants were loaded with occlusal force in stages 1 and 2. Finally, the data of the 27 participants who completed the evaluation at stage 2 were analyzed. The Wilcoxon signed‐rank test with Bonferroni correction was used to assess the differences in the oral functions among the different stages.ResultsThe implant survival rate was 93.8%. There were significant differences in the comminuting ability and occlusal contact area between stages 0 and 2 (p < .001 and p = .036, respectively) and stages 1 and 2 (p = .003 and p = .015, respectively). Regarding the maximum bite force, there was a significant difference between stages 1 and 2 (p = .018). However, there was no significant difference in the mixing ability between the three stages.ConclusionsWithin the limitations of this study, it was concluded that IARPDs in the mandible with short implants and magnetic attachments may improve oral functions.
Swimming exercise is a promising early intervention for autism‐like behavior in Shank3 deletion rats
Authors: Xu Dan , Meng Yunchen , An Shasha , Meng Wenshu , Li Hanran , Zhang Weinan , Xue Yaqi , Lan Xinyu , Wang Xiaoxi , Li Mingjuan , Zhang Xiaoyan , Zhihao Zhang , Zhao Yu , Yang Haodong , Zhang Chen , Zhang Rong , Zhen Zhiping 
Published: October 2022

AbstractIntroductionSHANK3 is an important excitatory postsynaptic scaffold protein, and its mutations lead to genetic cause of neurodevelopmental diseases including autism spectrum disorders (ASD), Philan McDermid syndrome (PMS), and intellectual disability (ID). Early prevention and treatment are important for Shank3 gene mutation disease. Swimming has been proven to have a positive effect on neurodegenerative diseases.MethodsShank3 gene exon 11–21 knockout rats were intervened by a 40 min/day, 5 day/week for 8‐week protocol. After the intervention, the rats were tested to behavioral measures such as learning and memory, and the volume and H‐spectrum of the brain were measured using MRI; hippocampal dendritic spines were measured using Golgi staining and laser confocal.ResultsThe results showed that Shank3‐deficient rats had significant deficits in social memory, object recognition, and water maze learning decreased hippocampal volume and number of neurons, and lower levels of related scaffold proteins and receptor proteins were found in Shank3‐deficient rats.ConclusionIt is suggested that early swimming exercise has a positive effect on Shank3 gene‐deficient rats, which provides a new therapeutic strategy for the prevention and recovery of neurodevelopmental disorders.
Impact of the preoperative clinical N stage on the prognosis of patients with colon cancer
Authors: Takaki Wataru , Arita Tomohiro , Kuriu Yoshiaki , Shimizu Hiroki , Kiuchi Jun , Ohashi Takuma , Yamamoto Yusuke , Konishi Hirotaka , Morimura Ryo , Shiozaki Atsushi , Ikoma Hisashi , Kubota Takeshi , Fujiwara Hitoshi , Okamoto Kazuma , Otsuji Eigo 
Published: October 2022

AbstractAimAlthough preoperative clinical staging (cStage) is performed for most cancer patients, limited information is currently available on the relationship with postoperative prognosis. We herein investigated the relationship between cStage and prognosis of colon cancer (CC) patients, particularly focusing on the presence or absence of clinical lymph node (LN) metastasis.MethodThis was a retrospective study on 840 consecutive patients with colon adenocarcinoma who underwent radical resection at our institution between January 2007 and December 2018. A Kaplan–Meier curve was used to analyse the prognosis of two groups: cN(+)pN(−); a group preoperatively diagnosed with clinical LN metastasis positive, but with no pathological LN metastasis postoperatively, and cN(−)pN(−); a group without clinical and pathological LN metastasis. We also investigated whether a clinical diagnosis is a more accurate prognostic factor than other clinical factors.ResultsAmong pN(−) cases, the 5‐year recurrence‐free survival rate was significantly lower in preoperatively diagnosed cN(+) cases than in cN(−) cases (79.4% vs. 95.6%, 3.04 years vs. 3.85 years, p < 0.01). In a multivariate analysis of various preoperative clinical factors in pStage II cases, including high risk factors for pStage II CC, cN(+) was identified as an independent prognostic factor (hazard ratio: 2.06, 95% CI: 1.02–4.27, p = 0.04).ConclusionPreoperatively over‐staged cN cases had a poorer prognosis than cases without over‐staging, indicating its potential as a prognostic factor. In addition to already known high risk factors in pStage II cases, the preoperative cStage may be an indication for adjuvant chemotherapy.
Dispersal syndromes in challenging environments: A cross‐species experiment
Authors: Cote Julien , Dahirel Maxime , Schtickzelle Nicolas , Altermatt Florian , Ansart Armelle , Blanchet Simon , Chaine Alexis S. , De Laender Frederik , De Raedt Jonathan , Haegeman Bart , Jacob Staffan , Kaltz Oliver , Laurent Estelle , Little Chelsea J. , Madec Luc , Manzi Florent , Masier Stefano , Pellerin Felix , Pennekamp Frank , Therry Lieven , Vong Alexandre , Winandy Laurane , Bonte Dries , Fronhofer Emanuel A. , Legrand Delphine 
Published: October 2022

AbstractDispersal is a central biological process tightly integrated into life‐histories, morphology, physiology and behaviour. Such associations, or syndromes, are anticipated to impact the eco‐evolutionary dynamics of spatially structured populations, and cascade into ecosystem processes. As for dispersal on its own, these syndromes are likely neither fixed nor random, but conditional on the experienced environment. We experimentally studied how dispersal propensity varies with individuals' phenotype and local environmental harshness using 15 species ranging from protists to vertebrates. We reveal a general phenotypic dispersal syndrome across studied species, with dispersers being larger, more active and having a marked locomotion‐oriented morphology and a strengthening of the link between dispersal and some phenotypic traits with environmental harshness. Our proof‐of‐concept metacommunity model further reveals cascading effects of context‐dependent syndromes on the local and regional organisation of functional diversity. Our study opens new avenues to advance our understanding of the functioning of spatially structured populations, communities and ecosystems.
Human monkeypox virus in a tertiary hospital in Madrid, Spain: An observational study of the clinical and epidemiological characteristics of 53 cases
Authors: García‐Piqueras Paloma , Bergón‐Sendín Marta , Córdoba‐García‐Rayo María , Vírseda‐González Daniel , Medrano‐Martínez Noelia , Jiménez‐Briones Luis , Lacasta‐Plasín Clara , Hernández de la Torre‐Ruiz Elisa , Balaguer‐Franch Inmaculada , Pulido‐Pérez Ana , Molina‐López Irene , Rodríguez‐Lomba Enrique , Barchino‐Ortiz Lucia , Suárez‐Fernández Ricardo , Nieto‐Benito Lula María 
Published: October 2022

AbstractA new outbreak of monkeypox virus (MPXV) infection, a zoonotic infection endemic in Central and West Africa, is spreading throughout the world with new epidemiology and clinical features. Our aim was to characterize patients presenting to Dermatology emergency room with a MPXV infection between 15 May and 30 June 2022 in a tertiary hospital in Madrid, Spain. We collected 53 patients and describe their clinical, demographic and epidemiological characteristics and followed their evolution. Most of the patients were men who had sex with men with high‐risk sexual practices and no recent travels abroad. Most of them (91%) had had a sexually transmitted infection before. All patients had typical skin lesions consisting of vesicular‐pustular rash with central umbilication which was localized or disseminated. The most frequent extracutaneous symptoms were fever, painful regional lymphadenopathy and asthenia. Proctitis was present in more than one third of patients. All patients were diagnosed by real time polymerase chain reaction of samples obtained from skin lesions. Pharyngeal and/or rectal exudates demonstrated MPXV in 74% of patients. The current worldwide outbreak of MPXV infections shows epidemiological and clinical differences from previous ones. Clinicians should be aware of these characteristics to correctly diagnose this emerging disease.