bluuebunny/crossref_metadata_2025_split huggingface dataset:
Éthos de singularité et éthos collectif dans deux pièces de J.-C. Grumberg : Dreyfus…et L’Atelier
Authors: Favart Françoise 
Published: September 2022

Parmi les genres littéraires, le théâtre écrit présente la particularité de s’accomplir dans la représentation vivante et parlée (Dufiet & Petitjean, 2013, p. 441). Celle-ci met la parole des locuteurs personnages et l’image qu’ils donnent à voir d’eux-mêmes au centre du dispositif scénique. Dans un corpus de textes de théâtre où les personnages se présentent comme une mimèsis des êtres vivants, l’éthos peut être entendu comme l’effet de réel d’une construction littéraire. Celle-ci repose entre autres sur le matériel langagier qui résulte des choix linguistiques et discursifs de l’auteur et des opérations de sélection qui de fait sont des manifestations de l’énonciation (Monte, 2016, p. 182). De la même manière que le style, l’éthos peut alors être envisagé comme un concept qui articule une intentionnalité, des formes et des effets (ibid., p. 187) discursifs et par conséquent aussi scéniques. Après avoir délimité l’arrière-plan théorique de notre étude, nous interrogerons les deux pièces de notre corpus : Dreyfus… (1974) et L’Atelier (1979) sur le rapport du locuteur personnage à sa parole dans la construction d’un éthos qui se décline à la fois dans le singulier et dans le collectif.
La fortune du Tartuffe de Molière dans les manuels scolaires depuis le xixe siècle
Authors: Calleja-Roque Isabelle 
Published: September 2022

Depuis la IIIe République, dans les programmes scolaires, Tartuffe a toujours été une des pièces phares de Molière. Sa fortune ne s’est jamais démentie et les manuels scolaires des lycées n’ont jamais cessé d’en proposer la lecture. C’est entre tradition et modernité que sa lecture a évolué depuis le xixe siècle jusqu’à aujourd’hui. Pendant longtemps, la comédie n’est pas vraiment expliquée par elle-même ; elle reste au service de l’interprétation morale des intentions de l’auteur telles qu’elles sont reconstituées par les historiens de la littérature et sa dimension comique n’est jamais abordée avant la fin du xxe siècle. L’ouverture des programmes vers la mise en scène, au xxie siècle, va cependant moderniser sa lecture dans la mesure où elle favorise une approche actualisante de la comédie qui permet aux adolescents d’aujourd’hui de comprendre que Tartuffe est toujours d’actualité parce qu’il nous parle de problèmes qui nous concernent encore.
Curing the pandemic of misinformation on COVID-19 mRNA vaccines through real evidence-based medicine - Part 2
Authors: Malhotra Aseem 
Published: September 2022

Background: Authorities and sections of the medical profession have supported unethical, coercive, and misinformed policies such as vaccine mandates and vaccine passports, undermining the principles of ethical evidence-based medical practice and informed consent. These regrettable actions are a symptom of the ‘medical information mess’: The tip of a mortality iceberg where prescribed medications are estimated to be the third most common cause of death globally after heart disease and cancer.Aim: To identify the major root causes of these public health failures.Methods: A narrative review of both current and historical driving factors that underpin the pandemic of medical misinformation.Results: Underlying causes for this failure include regulatory capture – guardians that are supposed to protect the public are in fact funded by the corporations that stand to gain from the sale of those medications. A failure of public health messaging has also resulted in wanton waste of resources and a missed opportunity to help individuals lead healthier lives with relatively simple – and low cost – lifestyle changes.Conclusion: There is a strong scientific, ethical and moral case to be made that the current COVID vaccine administration must stop until all the raw data has been subjected to fully independent scrutiny. Looking to the future the medical and public health professions must recognise these failings and eschew the tainted dollar of the medical-industrial complex. It will take a lot of time and effort to rebuild trust in these institutions, but the health – of both humanity and the medical profession – depends on it.Contribution: This article highlights the importance of addressing metabolic health to reduce chronic disease and that insulin resistance is also a major risk factor for poor outcomes from COVID-19.
The predictors of long–COVID in the cohort of Turkish Thoracic Society– TURCOVID multicenter registry
Authors: Baris Serap Argun , Toprak Oya Baydar , Cetinkaya Pelin Duru , Fakili Fusun , Kokturk Nurdan , Kul Seval , Kayalar Ozgecan , Tutuncu Yildiz , Azak Emel , Kuluozturk Mutlu , Yildiz Pinar Aysert , Deniz Pelin Pinar , Kilinc Oguz , Basyigit Ilknur , Boyaci Hasim , Hanta Ismail , Kose Neslihan , Sagcan Gulseren , Cuhadaroglu Caglar , Okur Hacer Kuzu , Ozger Hasan Selcuk , Ergan Begum , Hafizoglu Mehtap , Sayiner Abdullah , Temel Esra Nurlu , Ozturk Onder , Ciftci Tansu Ulukavak , Oguzulgen Ipek Kivilcim , Oguz Vildan Avkan , Bayraktar Firat , Ataoglu Ozlem , Ercelik Merve , Gulhan Pinar Yildiz , Erdem Aysegul Tomruk , Tor Muge Meltem , Itil Oya , Bayram Hasan 
Published: September 2022

Abstract

Objective:
To evaluate long-term effects of COVID-19, and to determine the risk factors in long-COVID in a cohort of the Turkish Thoracic Society (TTS)-TURCOVID multicenter registry.

Methods:
Thirteen centers participated with 831 patients; 504 patients were enrolled after exclusions. The study was designed in three-steps: (1) Phone questionnaire; (2) retrospective evaluation of the medical records; (3) face-to-face visit.

Results:
In the first step, 93.5% of the patients were hospitalized; 61.7% had a history of pneumonia at the time of diagnosis. A total of 27.1% reported clinical symptoms at the end of the first year. Dyspnea (17.00%), fatigue (6.30%), and weakness (5.00%) were the most prevalent long-term symptoms. The incidence of long-term symptoms was increased by 2.91 fold (95% CI 1.04-8.13, P=0.041) in the presence of chronic obstructive pulmonary disease and by 1.84 fold (95% CI 1.10-3.10, P=0.021) in the presence of pneumonia at initial diagnosis, 3.92 fold (95% Cl 2.29-6.72, P=0.001) of dyspnea and 1.69 fold (95% Cl 1.02-2.80, P=0.040) fatigue persists in the early-post-treatment period and 2.88 fold (95% Cl 1.52- 5.46, P=0.001) in the presence of emergency service admission in the post COVID period. In step 2, retrospective analysis of 231 patients revealed that 1.4% of the chest X-rays had not significantly improved at the end of the first year, while computed tomography (CT) scan detected fibrosis in 3.4%. In step 3, 138 (27.4%) patients admitted to face-to-face visit at the end of first year; at least one symptom persisted in 49.27% patients. The most common symptoms were dyspnea (27.60%), psychiatric symptoms (18.10%), and fatigue (17.40%). Thorax CT revealed fibrosis in 2.4% patients.

Conclusions:
COVID-19 symptoms can last for extended lengths of time, and severity of the disease as well as the presence of comorbidities might contribute to increased risk. Long-term clinical issues should be regularly evaluated after COVID-19.
Acute motor axonal neuropathy following anti-rabies human diploid cell vaccine
Authors: Chawla Tanushree , Sehgal Jyoti , Dabla Surekha , Goyal Vinay 
Published: September 2022

Abstract

Rationale:
Guillain Barre syndrome (GBS) is an acute neurological illness leading to quadriparesis with respiratory involvement. It can be triggered by infections, vaccinations, surgery, trauma, transplantation and drugs. Anti-rabies cell culture vaccines introduced to overcome the high rate of neurological complications associated with tissue based rabies vaccine, can be very rarely associated with GBS.

Patient concerns:
A 50-year-old female presented with acute severe upper back pain evolving into pure motor quadriparesis following administration of human diploid cell vaccine for rabies.

Diagnosis:
Acute motor axonal neuropathy variant of GBS following anti-rabies human diploid cell vaccine.

Interventions:
Intravenous high dose steroids.

Outcomes:
Patient recovered completely within 1 month.

Lessons:
Although anti-rabies cell culture vaccines are highly immunogenic and safe, they are rarely associated with GBS. Clinicians should be aware of this link because prompt diagnosis and treatment can result in complete recovery and avoid complications.
Effect of two different volumes of sodium hypochlorite on endodontic treatment outcome following single-visit root canal treatment
Authors: Jadhav Ganesh R. , Mittal Priya , Kalra Dheeraj 
Published: September 2022

Abstract

Aim:
This split-mouth (SM), randomized controlled trial was planned to assess the influence of two different volumes (15 ml and 25 ml) of 2.5% of sodium hypochlorite (NaOCl) on the endodontic treatment outcome of teeth with apical periodontitis (AP) by radiographic and clinical evaluation.

Materials and Methods:
The study protocol was approved by the ethics committee (25/XX/IEC/2017/11). Using block randomization, permanent lower molars with pulp necrosis and chronic AP (periapical index [PAI] of 3 or above) were allotted to two treatment groups as Group I (low volume [LV]) and Group II (high volume (HV)) wherein 3 ml and 5 ml of NaOCl irrigant were used after each Mtwo rotary file, respectively. This NaOCl was activated by a sonic handpiece. With power at 0.80, P < 0.05, and minimum clinically significant mean intergroup difference set at 0.40 units (standard deviation – 0.88 unit) while using the change in PAI score as the primary outcome, a total of 46 subjects per group were recruited to adequately show a difference in success at the 12-month follow-up. Clinical (at 24 h, 3, 6, 9, and 12 months) and radiographic (6 and 12 months) assessment of all cases was done.

Results:
Due to SM design of the study, there was no difference in the demographics of subjects between both the groups. Pain scores between both groups were statistically nonsignificant preoperatively (P = 0.857) and at 24 h (P = 0.852). However, there was statistically significant difference in preoperative and 24 h pain scores in Group I (P = 0.000) and Group II (0.000). Comparison of intergroup preoperative and 12-month follow-up PAI scores revealed no statistically significant difference (P = 0.667). However, there was statistically significant difference in preoperative and 12-month follow-up PAI scores in Group I (P = 0.000) and Group II (P = 0.000). Intergroup comparison of PAI scores at baseline (P = 0.894) and follow-up (P = 0.526) revealed no significant difference.

Conclusion:
Based on the results of the present study, it can be suggested that there is no significant advantage of using HV of NaOCl over LV as far as periapical healing and postendodontic pain are concerned.
Comparative evaluation of N-acetylcysteine and chlorhexidine as final irrigation on the push-out bond strength of different sealers
Authors: Ghatole Kiran , Indi Shreeshail , Diwanji Pavan , Janavathi  , Hambire Ashwini , Thimwala Aadil 
Published: September 2022

Abstract

Aim:
Using N acetyl cysteine (NAC) and Chlorhexidine as final irrigants, the study aims to examine the push out bond strength of distinct sealers.

Materials and Methods:
Access and biomechanical preparation were done on decoronated 80 single-rooted teeth. Canals were alternatively irrigated using 5ml of 5.25% NaOCl and 5ml of 17% EDTA solution during instrumentation. On the basis of final irrigation procedure, the samples are divided into two groups: Group 1 – NAC and Group 2 – 2% Chlorhexidine. Using paper points, canals were dried and subdivided depending on the sealers used, Group 1A and 2A- AH plus and 1B and 2B- BioRoot RCS. Teeth were obturated and middle root sections were tested for push-out bond strength using universal testing equipment. Statistical analysis was done.

Results:
NAC with AH-plus sealer had the maximum push-out strength, whereas Chlorhexidine with BioRoot RCS sealer had the lowest.

Conclusion:
NAC increases the bond strength of the obturating materials as the final irrigant. NAC can be considered as a final irrigant for endodontic therapy.
Expert Consensus on Diagnosis and Treatment of Adult Mental Stress-Induced Hypertension in China (2022 Revision): Part B
Authors: Lu Lin , Geng Qingshan , Wang Jian−an , Bai Chunlin , Cheng Gong , Cui Yinghua , Dong Bo , Fang Jianqun , Gao Feng , Huang Ruowen , Huang Shuwei , Li Yuming , Liu Gang , Liu Yuanyuan , Lu Yan , Ren Yanping , Mao Jialiang , Shi Dazhuo , Su Huimin , Sun Xinyu , Sun Xingguo , Tang Xiangdong , Tian Fengshi , Tu Hong , Wang Hao , Wang Qing , Wang Xiangqun , Wang Junmei , Wang Le , Wang Yibo , Wang Yumei , Wang Zhipeng , Wen Shaojun , Wu Hui , Wu Yanqing , Xiong Peng , Yu Guolong , Yang Ning , Zhao Xiaoling , Zhang Haicheng , Liu Meiyan 
Published: September 2022

Abstract
Mental stress has been recognized as an essential risk factor for hypertension. Therefore, experts specializing in cardiology, psychiatry, and Traditional Chinese Medicine organized by the Psycho-cardiology Group, College of Cardiovascular Physicians of Chinese Medical Doctor Association, and Hypertension Group of the Chinese Society of Cardiology proposed the expert consensus on the diagnosis and treatment of adult mental stress-induced hypertension in March 2021, which includes the epidemiology, etiology, diagnosis, and treatment of the mental stress-induced hypertension. This consensus will hopefully facilitate the clinical practice of this disorder. In addition, the COVID-19 pandemic has become one of the primary global sources of psychosocial stressors since the beginning of 2020, and the revision of this expert consensus in 2022 has increased the relevant content. This consensus consists of two parts. The sections of Part A include (I) Background and epidemiological characteristics, (II) Pathogenesis, and (III) Diagnosis. The sections of Part B contain (IV) Treatment recommendations, and (V) Prospects. This article presents Part B of the consensus.
Percutaneous embolization of renal pseudoaneurysms
Authors: Bagheri Seyed Morteza , Ghadamzadeh Mostafa , Chavoshi Mohammadreza 
Published: September 2022

Introduction:
We evaluated the efficacy of the mixture of autologous blood and a hemostatic agent, oxidized regenerative cellulose (ORC), as an alternative material for ultrasound (US)-guided percutaneous embolization of renal pseudoaneurysm (PA).

Methods:
In this retrospective study, consecutive patients diagnosed with renal PA were included. The exclusion criteria were: PA of the main renal artery, tiny PA not visualized on the colour doppler ultrasonography, PA more than 3 cm in max diameter or extracapsular PA with the possibility of massive bleeding, and patients with a history of coagulation disorders. After localizing the PA, a mixture of autologous blood and ORC was injected under US guidance with a 15G coaxial needle. Patients were followed up for at least 6 months.

Results:
Twenty-nine patients with PA were included, of which 26 had a history of percutaneous nephrolithotomy, and three patients had a history of renal biopsy (24 men and five women with an average age of 44.3 years). Gross hematuria was the most common mode of presentation. The mean size of the PA was 16.6 mm and the mean duration of follow-up was 9 months. The clinical and the technical success rate was 100%. The PA could be thrombosed in all the patients with a single-session of injection. No acute (hematoma, infection, and bleeding) or chronic (thromboembolic events, renal cortical atrophy, and recurrence) complications were seen.

Conclusion:
Percutaneous embolization of renal PA under US guidance with a mixture of autologous blood and ORC is an efficient and easily available first-line method to treat this potentially life-threatening condition when endovascular embolization or other expensive thrombotic agents are not available.
The role of tranexamic acid in reducing bleeding during transurethral resection of the prostate
Authors: Pranata Firmantya Hadi , Kloping Yudhistira Pradnyan , Hidayatullah Furqan , Rahman Zakaria Aulia , Yogiswara Niwanda , Rahman Ilham Akbar , Febriansyah Nafis Audrey , Soebadi Doddy Moesbadianto 
Published: September 2022

Introduction:
Transurethral resection of the prostate (TURP) is regarded as the current gold standard surgical intervention for benign prostatic hyperplasia (BPH). However, this procedure is associated with significant chances of intraoperative and postoperative bleeding. Several studies have reported the role of tranexamic acid in prostatic surgeries, but, its role in TURP is still unclear. This review aims to evaluate the role of tranexamic acid in reducing the blood loss during TURP.

Materials and Methods:
A systematic search was performed on Medline, Scopus, Embase, and Cochrane, up to December 2021. Relevant randomized controlled trials (RCTs) evaluating the role of tranexamic acid in TURP were screened using our predefined eligibility criteria. Data were expressed as odds ratio (OR) or mean difference (MD) with 95% confidence intervals (CIs). All analyses were performed using RevMan 5.4 (Cochrane Collaboration, UK).

Results:
Six trials were included in this meta-analysis, comprising of 582 patients with BPH who underwent TURP. The meta-analysis revealed an insignificant difference in the rate of blood transfusion (OR 0.68, 95% CI 0.34, 1.34, P = 0.27) but, a significantly lower amount of blood loss and a lower reduction in the hemoglobin (Hb) levels in the patients receiving tranexamic acid as compared to the control group (MD − 127.03, 95% CI − 233.11, −20.95, P = 0.02; MD − 0.53, 95% CI − 0.84, −0.22, P < 0.01; respectively). Also, the operative time (P = 0.12) and the length of hospitalization (P = 0.59) were similar between the two groups.

Conclusion:
The administration of tranexamic acid was not found to be effective in reducing the need for blood transfusion, the operative time, and the length of hospitalization during the TURP. However, it could reduce the amount of blood loss and the fall in the Hb levels.
Sperm DNA Fragmentation in Reproductive Medicine
Authors: Alahmar Ahmed T. , Singh Rajender , Palani Ayad 
Published: September 2022

ABSTRACT
Approximately 15% of the world's couples suffer from infertility during their reproductive period of which the male factor is responsible for 50% of cases. Male factor infertility is multifactorial in origin, and sperm DNA fragmentation (SDF) has also been linked to male infertility including idiopathic male infertility. Some degree of controlled DNA nicking is essential for adequate DNA compaction, but excessive SDF is usually associated with reduced male fertility potential, reduced fertilisation, poor embryo quality, recurrent pregnancy loss and poor assisted reproductive techniques (ARTs) outcomes. Although semen analysis remains the gold standard for diagnosis of male factor infertility worldwide, its limitations motivated the search and the development of complementary tests of sperm function and integrity. SDF assay is an emerging diagnostic tool in infertile men, and several indications for SDF testing in infertile couples have also been proposed. The use of SDF in routine male infertility assessment is, however, still controversial. Furthermore, both direct and indirect SDF tests are now available. Hence, the present review was conducted to summarise the recent evidence of SDF, underlying mechanisms, clinical indications, diagnostic tests, as well as the role of SDF in male factor infertility, pregnancy and ART outcomes.
Modafinil for Wakefulness and Disorders of Consciousness in the Critical Care Units
Authors: Amer Marwa , Jamil Mouhamad Ghyath , Kseibi Eiad 
Published: September 2022

Objective:
Cognitive improvement after critical illness is complex. Neurostimulants are used to speed up physical and mental processes. Modafinil for wakefulness in the intensive care unit (ICU) holds the potential to facilitate recovery from cognitive impairment. We aim to provide an updated narrative review of the current evidence on modafinil use for wakefulness and disorders of consciousness (DoC) and describe modafinil effect for wakefulness in eight adults admitted to our ICUs at King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Methods:
For the narrative review, we searched MEDLINE for modafinil studies as neurostimulant for wakefulness and DoC published from inception through May 30, 2022, with no language or study design restriction, focused on adults, and neurocritical care population (traumatic brain injury [TBI], poststroke). The case series included adult patients (age ≥18 years), admitted between January 2017 and June 2020 to coronavirus disease 2019 (COVID-19) and non-COVID ICUs with an ICU stay of at least 48 h, started on modafinil during ICU stay for at least 48 h and required ventilatory support.

Results:
For the narrative review, we identified five studies in TBI (n = 285; two RCTs and three retrospective cohort studies), one systematic review poststroke (n = 120), two studies on ICU population, and one case report describing modafinil use in post-COVID encephalopathy. We also identified additional three recent studies that were published after systematic review for modafinil use poststroke. A total of eight patients out of approximately 10,000–13,000 ICU admissions used modafinil over the 4 years' period and described in our case series; 3 admitted to COVID-19 ICU, 4 surgical ICU, and 1 transplant ICU. Modafinil 100–200 mg daily was started for median duration of 4 days and median initiation time in relation to ICU admission was 11 (IQR 9–17) days. Glasgow Coma Score improvement was noted in 5 (62.5%) patients. No significant adverse effects were documented.

Conclusion:
In this case series, modafinil as neurostimulant was infrequently prescribed in ICU over the 4 years and was associated with a low incidence of adverse effects. Based on our observations, modafinil might have a potential role when administered to certain patients. Our findings can be biased by confounders that influence cognitive function and recovery. Larger studies are warranted to evaluate its role in this indication fully.