bluuebunny/crossref_metadata_2025_split huggingface dataset:
Muffins fortified with Dacryodes macrophylla L. fruit: quality and sensory evaluation
Authors: Ndinchout Alvine Sandrine , Chattopadhyay Debapriya , Ascension Nyegue Maximilienne , Singh Narpinder , Paul Moundipa Fewou 
Published: January 2022

Introduction. Due to the increasing demand for natural and functional products, scientists together with industries are conducting research to improve the nutritional quality of food. One of the ways to enhance the functionality of food is to add fruits or vegetables to their formulations. In this study, we attempted to develop muffins fortified with Dacryodes macrophylla L. fruit as a value-added ingredient.
Study objects and methods. Our study objects included D. macrophylla L. extract and six muffins: three eggless samples and three egg-containing samples. Each group included control and experimental samples. The experimental samples containing 0.5 and 1% of D. macrophylla L. extract instead of wheat flour were evaluated for muffin-making properties. All the samples were analyzed for their physicochemical, antioxidant, and sensory properties, as well as rheological parameters.
Results and discussion. We found that D. macrophylla L. reduced the water activity, color values (L*, a*, b*), and firmness of muffins. It had no significant effect on baking loss, height, moisture, cohesiveness, springiness, gumminess or chewiness, but tended to decrease the specific volume of muffins. However, D. macrophylla L. fruit increased the specific gravity, improved rheology properties, and tended to increase adhesiveness and mineral contents. Na and K varied from 5.93 to 7.75 and 2.88 to 7.35 mg/g, respectively. Furthermore, D. macrophylla L. fruit significantly improved the muffins’ antioxidant activities. According to sensory evaluation, the muffins made with egg solids and 0.5% of D. macrophylla L. fruit had higher sensory scores than the other experimental samples.
Conclusion. D. macrophylla L. fruit is a good potential ingredient for enriching muffins and developing new functional bakery products. However, further research is needed to improve the color reproduction of muffins and determine the optimal concentration of D. macrophylla L.
Kumquat fruit and leaves extracted with different solvents: phenolic content and antioxidant activity
Authors: Büyükkormaz Çağrı , Küçükbay F. Zehra 
Published: January 2022

Introduction. Kumquat is a good source of vitamin C, as well as phenolic and flavonoid substances. In this study, we used various solvents to obtain extracts from fresh and lyophilized dried fruits and leaves of kumquat plant, as well as six mutants, to compare their total phenolic and flavonoid contents and antioxidant activities.
Study objects and methods. The total phenolic and flavonoid content was determined by the Folin-Ciocalteu method and the colorimetric method, respectively. The antioxidant capacities of the extracts were determined by commonly used antioxidant tests, such as the DPPH radical scavenging activity, reducing power, and metal chelating activity.
Results and discussion. The total phenolic content of the extracts was in the range of 3705–86 329 mg GAE/g extract. The total amount of flavonoid substance ranged from 5556 to 632 222 mg QUE/g extract. The highest free radical scavenging activity was observed in the kumquat leaves. We also found that the activity of dried fruit was lower than that of fresh fruit. According to our results, the differences in the phenolic contents of the studied plants affected their antioxidant properties. We determined that the extracts with a high phenolic content showed high antioxidant activity. No significant difference was detected between the rootstock kumquat type and its mutants. Finally, we found no chelating activity in the extracts obtained from fresh and lyophilized dried fruits.
Conclusion. Kumquat fruit and its leaves can be considered as functional foods due to phenolic compounds, which are able to neutralize free radicals.
Conceptual Reverse Logistics Model used by Online Retailers Post Covid-19 Lockdown
Authors: Kushwaha Purvi 
Published: January 2022

Coronavirus disease (Covid-19) is an infectious disease caused by a newly found coronavirus. Coronavirus 2(SARS-CoV-2), caused an illness known as Covid-19, which was similar to SARS and was characterized usually by fever and breathing symptoms. World Health Organization in March 2020 declared Covid-19 as pandemic. Social distancing is the only measure in the absence of any vaccine to reduce the spread of this virus so many countries including India are going under lockdown. In the lockdown, the Government ordered closure of all the brick-and-mortar businesses. In this time of crises customers have only choice to purchase essential products from e-commerce portals. Prime Minister Narendra Modi announced that essential items could be purchased through e-commerce portals, all e-commerce businesses were instructed by the Ministry of Consumer Affair to take proper precautions and hygiene in their entire supply chain process. This paper suggests a model to incorporate hygiene in reverse logistics for online retailers post lockdown.
Empowerment processes, programs, and outputs in increasing self-efficacy and their influence on individual performance
Authors: Vandayani Prima , Sumarni Teti 
Published: January 2022

After the second wave of the COVID-19 pandemic in Indonesia, the MSME business sector was significantly affected, data from the Ministry of Manpower and BPJS Employment in August 2021 explained that there were 2.8 million workers who were directly affected by COVID-19. They consist of 1.7 million formal workers who have been laid off and 749.4 thousand have been laid off. Based on the results of observations in August 2021, there MSME sectors in Indonesia that have been hardest hit, namely MSMEs in transportation, services, and tourism. To deal with the current pressures of difficult economic conditions, it takes a high level of self-efficacy from MSMEs to rise from adversity, rebuild affected businesses by empowering themselves through programs, processes, and outputs, these three factors are determinants of MSME self-efficacy carried out to improve return market demand. Through explanatory research, 400 samples were taken. The study aimed to determine the role of program empowerment, process, and output on MSME self-efficacy and their effect on increasing market demand using quantitative methods. Results show a positive and significant effect of programs, processes, and empowerment outputs on increasing market demand through MSME self-efficacy and empowerment output to increase market demand through MSME self-efficacy.
Mutation in MCL1 predicted loop to helix structural transition stabilizes MCL1-Bax binding interaction favoring cancer cell survival
Authors: ES Deepak Shyl , Malgija Beutline , Iniyan Appadurai Muthamil , Vincent Samuel Gnana Prakash 
Published: January 2022

Myeloid cell leukemia-1 (MCL1), an anti-apoptotic BCL-2 family protein
plays a major role in the control of apoptosis as the regulator of
mitochondrial permeability which is deregulated in various solid and
hematological malignancies. Interaction of the executioner proteins
Bak/Bax with anti-apoptotic MCL1 and its cellular composition determines
the apoptotic or survival pathway. This study highlighted the
deleterious MCL1-Bax stabilizing effect of the mutation V220F on MCL1
structure through computational protein-protein interaction predictions
and molecular dynamics simulations. The single point mutation at V220F
was selected as it is residing at the hydrophobic core region of BH3
conserved domain, the site of Bax binding. The molecular dynamics
simulation studies showed increase in stability of the mutated MCL1
before and after Bax binding comparable with the native MCL1. The
clusters from free energy landscape found out structural variation in
folding pattern with additional helix near the BH3 domain in the mutated
structure. This loop to helix structural change in the mutated complex
favored stable interaction of the complex and also induced Bax
conformational change. Moreover, molecular mechanics based binding free
energy calculations confirmed increased affinity of Bax towards mutated
MCL1. Residue-wise interaction network analysis showed the individual
residues in Bax binding responsible for the change in stability and
interaction due to the protein mutation. In conclusion, the overall
findings from the study reveal that the presence of V220F mutation
on MCL1 is responsible for the structural confirmational change leading
to disruption of its biological functions which might be responsible for
tumorigenesis. The mutation could possibly be used as future diagnostic
markers in treating cancers.
Reliability of an indirect bone-probing method for diagnosis of labial bone crest level of the mandibular anterior teeth
Authors: Barros Sérgio Estelita , Calvi Jeverson , Chiqueto Kelly , Janson Guilherme 
Published: January 2022

ABSTRACT

Objectives
To evaluate the null hypothesis that there would be no difference between the labial bone crest level of the mandibular anterior teeth evaluated with an indirect bone-probing method (IBP) and cone-beam computed tomography (CBCT).

Materials and Methods
Twenty-nine adult patients with a mean age of 32.15 ± 8.75 years were enrolled. An IBP based on indirect tactile perception was used to determine the labial bone crest level of the mandibular anterior teeth clinically. Bone crest perception degree, gingival thickness, and patient discomfort during IBP were also recorded. CBCT scans were used to evaluate the level and thickness of the labial bone crest. IBP and CBCT methods were compared statistically. The significance level was set at 5%.

Results
There was a significant difference between the labial bone crest level diagnosed by IBP and CBCT. However, the difference was not clinically significant. IBP and CBCT measurements were significantly and strongly correlated (R = 0.74). Thinner gingival tissue was associated with a higher perception of bone crest. Only two patients reported mild to moderate discomfort during IBP.

Conclusions
IBP allowed the labial bone crest level to be determined with acceptable clinical accuracy, especially in patients with thinner gingival tissue.
Gut Microbiome Composition Is Predictive of Incident Type 2 Diabetes in a Population Cohort of 5,572 Finnish Adults
Authors: Ruuskanen Matti O. , Erawijantari Pande P. , Havulinna Aki S. , Liu Yang , Méric Guillaume , Tuomilehto Jaakko , Inouye Michael , Jousilahti Pekka , Salomaa Veikko , Jain Mohit , Knight Rob , Lahti Leo , Niiranen Teemu J. 
Published: January 2022

OBJECTIVE
To examine the previously unknown long-term association between gut microbiome composition and incident type 2 diabetes in a representative population cohort.

RESEARCH DESIGN AND METHODS
We collected fecal samples from 5,572 Finns (mean age 48.7 years; 54.1% women) in 2002 who were followed up for incident type 2 diabetes until 31 December 2017. The samples were sequenced using shotgun metagenomics. We examined associations between gut microbiome composition and incident diabetes using multivariable-adjusted Cox regression models. We first used the eastern Finland subpopulation to obtain initial findings and validated these in the western Finland subpopulation.

RESULTS
Altogether, 432 cases of incident diabetes occurred over the median follow-up of 15.8 years. We detected four species and two clusters consistently associated with incident diabetes in the validation models. These four species were Clostridium citroniae (hazard ratio [HR] 1.21; 95% CI 1.04–1.42), C. bolteae (HR 1.20; 95% CI 1.04–1.39), Tyzzerella nexilis (HR 1.17; 95% CI 1.01–1.36), and Ruminococcus gnavus (HR 1.17; 95% CI 1.01–1.36). The positively associated clusters, cluster 1 (HR 1.18; 95% CI 1.02–1.38) and cluster 5 (HR 1.18; 95% CI 1.02–1.36), mostly consisted of these same species.

CONCLUSIONS
We observed robust species-level taxonomic features predictive of incident type 2 diabetes over long-term follow-up. These findings build on and extend previous mainly cross-sectional evidence and further support links between dietary habits, metabolic diseases, and type 2 diabetes that are modulated by the gut microbiome. The gut microbiome can potentially be used to improve disease prediction and uncover novel therapeutic targets for diabetes.
PROFESSIONAL KNOWLEDGE FORMATION AMONG STUDENTS OF HIGHER PEDAGOGICAL INSTITUTIONS FOR THE TRAINING OF QUALIFIED KETTLEBELL LIFTERS
Authors: Павлов Валерий Юрьевич , Бобина Ольга Николаевна , Вязигин Алексей Юрьевич 
Published: January 2022

В статье описаны обоснование, разработка и результаты внедрения методического материала по теме «Подготовка спортсменов высокой квалификации» для учебных дисциплин по силовым видам спорта, преподаваемых в университетах и на факультетах физической культуры и спорта. Обоснование наполнения рассматриваемой темы опирается на научно-методические подходы к планированию тренировочных нагрузок в спорте, теории и методики спортивной тренировки. Разработана программа подготовки квалифицированных гиревиков на предсоревновательном этапе по системе «пирамида». Определено соотношение объема общей физической подготовленности и специальной физической подготовленности в процентах и тоннаж основных и вспомогательных упражнений на предсоревновательном этапе.Экспериментально доказана эффективность разработанной программы подготовки квалифицированных гиревиков на предсоревновательном этапе по системе «пирамида».
The article presents the rationale, the development and results of testing of educational material on the topic “Training of highly qualified athletes” for academic disciplines in power sports, pedagogical physical culture and sports improvement taught at universities and at the faculties of physical culture and sports. The rationale for the content of the educational topic is based on scientific and methodological approaches to the planning of training loads in sports, theories and methods of sports training. The methodology of training highly qualified athletes according to the “pyramid” system is used in many sports, such as weightlifting, sambo, swimming, etc., but this system has not been used in kettlebell lifting, therefore it requires its own justification. From all of the above, the study of the training methodology for qualified high-skilled kettlebell lifters at the pre-competition stage is quite relevant. A program has been developed for training qualified guards on the preset stage according to the Pyramid system. The percentage ratio of the volume of general physical and special physical training and tonnage of the main and auxiliary exercises on the preset stage is determined. The effectiveness of the developed program for the preparation of qualified guards on the preset stage on the Pyramid system was experimentally proved. The educational material, theoretically substantiated, developed and tested in the training process of kettlebell lifters, is introduced into the content of the educational topic “Training of highly qualified athletes” of disciplines taught at the faculties of physical culture and sports.
FAMILY IDENTITY OF STUDENTS OF PEDAGOGICAL DIRECTIONS IN MODERN CONDITIONS
Authors: Ёлкина Ксения Константиновна 
Published: January 2022

В данной статье раскрыта сущность понятий «молодежь», «студенческая молодежь». Определены основные факторы, способствующие возникновению проблемы деформации семейных ценностей. Описаны социально-демографические процессы, протекающие в современной России.Представлены результаты диагностики семейной идентичности студентов, отражающие иерархию семейных ценностей студентов, социальные роли, с которыми они себя идентифицируют, типы адаптации и сплоченности родительских семей студентов.Результаты данного исследования могут быть использованы при дальнейшей разработке программы развития семейной идентичности и ее внедрении в процесс обучения в вузе.
This article reveals the essence of the concepts of «youth», «student youth». The main factors contributing to the emergence of the problem of deformation of family values have been determined. The socio-demographic processes taking place in modern Russia are described. The concept of family identity is considered as a person’s belonging to a family group, reflecting his commitment to family values and manifesting itself at the cognitive, affective and behavioral levels. The formation of family identity is characterized by a person’s involvement in family life, the presence of positive emotions and attitudes towards creating their own family, showing interest in family history, in helping and caring for parents and grandparents. The article presents the results of diagnostics of the family identity of students, reflecting the hierarchy of family value students, the social roles with which they identify themselves, the types of adaptation and cohesion of the parental families of students. The results of this study can be used in the further development of a program for the development of family identity and its implementation in the learning process at a university. In the context of the transformation of the family as a social institution, purposeful work is needed to develop the family identity of students – future teachers, who in the future will interact with the family, where it will be possible to jointly form the family identity of schoolchildren based on traditional values.
Agricultural Co-Product Management: An LCA Perspective on the Use of Safflower Oilcake from Bio-Oil Production in Umbria Region, Italy
Authors: Pelaracci Simone , Rocchi Lucia , Romagnoli Francesco , Boggia Antonio , Paolotti Luisa 
Published: January 2022

Abstract
This work evaluates the impact of cultivating Safflower (Carthamus tinctorius L.) in marginal lands of the Umbrian territory (Italy) to produce oil. The analysis considers the entire production process, aiming to understand which are the most impacting factors. In particular, the work assesses the environmental savings deriving from the reuse of the main by-product of the oil extraction process, i.e. the cake, for animal feed purposes. The evaluation was carried out by means of a cradle-to-gate LCA. The results show that the greatest impacts are due to the crop fertilization. However, such an impact is almost completely compensated by the use of the cake in feed production.
IMPLEMENTASI HARGA SAHAM SEBAGAI PEMODERASI PENGARUH FAKTOR-FAKTOR KINERJA KEUANGAN TERHADAP NILAI PERUSAHAAN
Authors: Supitriyani Supitriyani , Pardede Christine , Siahaan Yansen 
Published: January 2022

Tujuan dari penelitian ini adalah: untuk mengetahui gambaran likuiditas, struktur modal, profitabilitas, dan nilai perusahaan serta pengaruh likuiditas, struktur modal, dan profitabilitas terhadap nilai perusahaan pada PT Delta Djakarta, Tbk yang terdaftar di Bursa Efek Indonesia baik secara simultan maupun parsial dengan harga saham sebagai variabel moderating. Penelitian ini dilakukan dengan metode analisis deskriptif kualitatif dan analisis deskriptif kuantitatif. Pengumpulan data dilakukan dengan metode dokumentasi. Teknik analisis yang digunakan adalah uji asumsi klasik, analisis regresi linier berganda, koefisien korelasi, koefisien determinasi, dan uji hipotesis. Hasil analisis regresi linier berganda yaitu: Ŷ = -7,642 - 0,079X1 + 96,642X2 +26,571X3, berarti terdapat pengaruh negatif antara likuiditas terhadap nilai perusahaan dan terdapat pengaruh positif antara struktur modal, dan profitabilitas terhadap nilai perusahaan. Hasil analisis koefisien kolerasi dan determinasi yaitu r= 0,947 dan nilai r= 0,897. Hasil uji F menunjukkan tingkat sig alpha (0,0010,05), berarti likuiditas, struktur modal, dan profitabilitas berpengaruh signifikan terhadap nilai perusahaan. Hasil uji t untuk likuiditas, tingkat sig alpha (0,4610,05), berarti likuiditas tidak berpengaruh signifikan terhadap nilai perusahaan. Hasil uji t untuk struktur modal, tingkat sig alpha (0,0690,05), berarti struktur modal tidak berpengaruh signifikan terhadap nilai perusahaan. Hasil uji t untuk profitabilitas, tingkat sig alpha (0,0000,05), berarti profitabilitas berpengaruh signifikan terhadap nilai perusahaan. Hasil uji residual menunjukkan bahwa harga saham tidak mampu memoderasi pengaruh likuiditas, struktur modal, dan profitabilitas terhadap nilai perusahaan pada PT Delta Djakarta, Tbk yang terdaftar di Bursa Efek Indonesia
OPTIMASI PARAMETER PROSES PENJEMURAN GABAH DENGAN MENGGUNAKAN METODE TAGUCHI
Authors: Fatah Kemas Muhammat Abdul , Wisnaningsih Wisnaningsih 
Published: January 2022

Proses penjemuran gabah bertujuan untuk mengeringkan gabah di bawah sinar matahari secara langsung tanpa perantara (terbuka). Pengeringan dengan cara ini menjadi pilihan umumnya petani karena menguntungkan secara ekonomi malaupun memiliki kekurangan terkait dengan penyusutan karena kehilangan selama proses penjemuran. Pada cuaca terik, proses pengeringan padi sampai pada tingkat GKP diperlukan waktu 2 – 3 hari. Penelitian ini ditujukan untuk mengoptimasi proses penjemuran dengan mempertimbangkan faktor-faktor yang mempengaruhi yaitu, media alas hamparan gabah (media jemur), tebal hamparan gabah dan frekuensi pembalikan. Penelitian dilakukan melalui sejumlah eksperimen dengan menggunakan desain eksperimen metode Taguchi L9 (33). Dari hasil perhitungan efek mean dan SNR diketahui bahwa frekuensi pembalikan menempati urutan ke-1, diikuti media jemur dan tebal gabah secara berturut-turut, pengaruhnya terhadap penyusutan kadar air, dan untuk mendapatkan proses penjemuran yang optimal, frekuensi pembalikan sebanyak 4 kali, kombinasi terpal talang dan terpal plastik sebagai media jemur, dan tebal gabah adalah 2 cm. Analisis varians mengungkapkan bahwa ke-3 faktor tidak siginifikan pengaruhnya terhadap penyusutan kadar air dengan kontribusi sebesar 77,17%.
THE DEMONIC VITALISM OF THE FEMME FATALE AS A TRAGIC EXPRESSION OF REBELLION – KAP ŠPANSKE KRVI (A DROP OF SPANISH BLOOD) BY MILOŠ CRNJANSKI
Authors: Jaćimović Sladjana 
Published: January 2022

This paper points to the exceptional place of the novel Kap španske krvi (A Drop of Spanish Blood, 1932) in the literary work of Miloš Crnjanski and Serbian literature of the 20th century. The novel is overpowered by other great literary pieces by Crnjanski Dnevnik o Čarnojeviću (The Journal of Čarnojević), Seobe (Migrations), Druga knjiga Seoba (Other books of Migrations), Roman o Londonu (A Novel about London). Nevertheless, it is interpreted as the first Serbian novel in which the model of a fatal woman is activated and, in the era of modernism, revitalizes the romantic concept of femme fatale.
The importance of gut health in early life for long term health
Authors: Kadim Muzal , Masita Bertri Maulidya 
Published: January 2022

Introduction. The gut microbiota plays an important role in the normal functioning of the host organism. The microbiota of healthy newborn affected by many factors such as prenatal exposures, maternal nutrition, mode of delivery, type of feeding, introduction to solid food and its type, geography, and antibiotics consumption; and its composition continues to mature until reaching 3 years of age. Normal gut microbiota is essential in gut health, and play an important role in our homeostasis. Therefore, gut microbiota is considered a crucial factor for proper early life development and lifelong health. Prebiotics, along with probiotics, may alter gut microbiota composition thus play a role in the prevention of various diseases associated with dysbiosis condition.
Methods. Advanced search for relevant literatures in PubMed, Cochrane, and Willey was conducted. After assessing the relevancy and eligibility, articles were selected and critically appraised.
Conclusions. Accumulating evidence from different studies has shown that the occurrence of a disease is often preceded by early alterations of the microbiota. Many studies established correlation between gut microbiota dysbiosis with diseases pathogenesis i.e obesity and other metabolic syndrome, asthma and allergies, also stress-related disorder. Prebiotic supplementation has proven to be effective in obesity, asthma and allergies management, also beneficial for immune system.