bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antitumor efficacy of90Y-NM600 targeted radionuclide therapy and PD-1 blockade is limited by regulatory T cells in murine prostate tumors
Authors: Potluri Hemanth K , Ferreira Carolina A , Grudzinski Joseph , Massey Christopher , Aluicio-Sarduy Eduardo , Engle Jonathan W , Kwon Ohyun , Marsh Ian R , Bednarz Bryan P , Hernandez Reinier , Weichert Jamey P , McNeel Douglas G 
Published: August 2022

BackgroundSystemic radiation treatments that preferentially irradiate cancer cells over normal tissue, known as targeted radionuclide therapy (TRT), have shown significant potential for treating metastatic prostate cancer. Preclinical studies have demonstrated the ability of external beam radiation therapy (EBRT) to sensitize tumors to T cell checkpoint blockade. Combining TRT approaches with immunotherapy may be more feasible than combining with EBRT to treat widely metastatic disease, however the effects of TRT on the prostate tumor microenvironment alone and in combinfation with checkpoint blockade have not yet been studied.MethodsC57BL/6 mice-bearing TRAMP-C1 tumors and FVB/NJ mice-bearing Myc-CaP tumors were treated with a single intravenous administration of either low-dose or high-dose90Y-NM600 TRT, and with or without anti-PD-1 therapy. Groups of mice were followed for tumor growth while others were used for tissue collection and immunophenotyping of the tumors via flow cytometry.Results90Y-NM600 TRT was safe at doses that elicited a moderate antitumor response. TRT had multiple effects on the tumor microenvironment including increasing CD8 +T cell infiltration, increasing checkpoint molecule expression on CD8 +T cells, and increasing PD-L1 expression on myeloid cells. However, PD-1 blockade with TRT treatment did not improve antitumor efficacy. Tregs remained functional up to 1 week following TRT, but CD8 +T cells were not, and the suppressive function of Tregs increased when anti-PD-1 was present in in vitro studies. The combination of anti-PD-1 and TRT was only effective in vivo when Tregs were depleted.ConclusionsOur data suggest that the combination of90Y-NM600 TRT and PD-1 blockade therapy is ineffective in these prostate cancer models due to the activating effect of anti-PD-1 on Tregs. This finding underscores the importance of thorough understanding of the effects of TRT and immunotherapy combinations on the tumor immune microenvironment prior to clinical investigation.
A Santa Casa de Misericórdia do Maranhão e a concessão de dotas às moças órfãs e pobres no século XIX
Authors: Caldas Ana Caroline Silva 
Published: August 2022

A Santa Casa de Misericórdia, criada em 1498 na cidade de Lisboa, foi responsável no cuidado dos vulneráveis, envolvendo significativa parcela da população. As práticas caritativas possibilitaram a assistência em diversas esferas, como a hospitalar, funerária e financeira. Dentre as atividades, a Santa Casa se destacou no cuidado de mulheres com a criação de recolhimentos femininos e Casas, tornando-se uma prática além das fronteiras portuguesas. Com a expansão para o Ultramar, em São Luís do Maranhão a Misericórdia remonta ao período colonial, possuindo maior relevância para a sociedade a partir do século XIX, momento da fundação da Casa dos Expostos, destinados a acolher recém-nascidos e crianças abandonadas ou entregues a instituição, oferecendo educação a ambos os sexos e a possibilidade do dote caso as mulheres fossem ao altar, que ao longo da trajetória feminina na irmandade foram inúmeros os percalços. Dessa forma, o presente artigo versa sobre a concessão de dotes na instituição da Santa Casa de Misericórdia do Maranhão, utilizando como fontes os jornais do século XIX, disponibilizados pela Biblioteca Nacional Digital, possibilitando analisar as problemáticas referentes a significância do dote em São Luís, o fardo para a irmandade em cuidar das expostas e o contato com o Recolhimento de Nossa Senhora da Anunciação e Remédios. Conectados, esses fatores tornavam a situação das mulheres pobres à mercê do casamento ou trabalho, visto que a busca para saírem dotadas dos estabelecimentos possuía prazo de validade.
Association of In‐Hospital Hemoglobin Drop With Decreased Myocardial Salvage and Increased Long‐Term Mortality in Patients With Acute ST‐Segment–Elevation Myocardial Infarction
Authors: Dutsch Alexander , Graesser Christian , Voll Felix , Novacek Sophie , Eggerstedt Robert , Armbruster Nicolás López , Laugwitz Karl‐Ludwig , Cassese Salvatore , Schunkert Heribert , Ndrepepa Gjin , Kastrati Adnan , Kessler Thorsten , Sager Hendrik B. 
Published: August 2022

Background
Anemia and blood loss occur often in patients with ST‐segment–elevation myocardial infarction (STEMI). In‐hospital hemoglobin drop is associated with 1‐year mortality in patients with acute coronary syndrome. However, data on the effect of hemoglobin reduction on myocardial salvage and long‐term outcomes are scarce. We investigated the impact of in‐hospital hemoglobin drop on myocardial salvage and 5‐year mortality in patients with STEMI treated with primary percutaneous coronary intervention.

Methods and Results

In‐hospital hemoglobin drop was defined as a decrease in hemoglobin levels from admission and nadir hemoglobin values. Patients were categorized as having the following: no drop, minimal drop (<3 g/dL), minor drop (≥3 to <5 g/dL), and major drop (≥5 g/dL). Myocardial area at risk and infarct size were measured using serial single‐photon emission computerized tomography imaging. The co‐primary outcomes were myocardial salvage and 5‐year all‐cause mortality. Of 1204 patients, 1169 (97.1%) showed a hemoglobin drop during hospitalization: minimal, minor, and major drop occurred in 894 (74.3%), 214 (17.8%), and 61 (5.1%) patients, respectively. Myocardial salvage was reduced in patients with minimal (median, 0.53 [interquartile range, 0.27–0.83]), minor (median, 0.40 [interquartile range, 0.18–0.62]), and major (median, 0.40 [interquartile range, 0.14–0.77]) drop compared with patients without drop (median, 0.70 [interquartile range, 0.44–1.0],
P
<0.001). After adjusting for covariates, hemoglobin drop remained an independent correlate of poor myocardial salvage. A drop of ≥3 g/dL was associated with reduced left ventricular function at 6 months and with increased mortality at 5‐year follow‐up after STEMI.

Conclusions
In patients with STEMI undergoing primary percutaneous coronary intervention, in‐hospital hemoglobin drop was associated with reduced myocardial salvage, left ventricular function, and increased long‐term mortality.
A review of Iranian Eucharitidae (Hymenoptera: Chalcidoidea), with description of four new species and discussion on Western Palaearctic species
Authors: Lotfalizadeh Hossein , Moghaddam Mostafa Ghafouri , Rasplus Jean-Yves 
Published: August 2022

Abstract
Nine species of Eucharitidae belonging to three genera, namely Eucharis (Eucharis) adscendens (Fabricius, 1787); E. (E.) carinifera Gussakovskij, 1940; E. (E.) caspicus Lotfalizadeh & Rasplus sp. nov.; E. (E.) shajariani Lotfalizadeh & Ghafouri Moghaddam sp. nov.; Eucharis (E.) vashicus Lotfalizadeh & Ghafouri Moghaddam, sp. nov.; E. (Psilogastrellus) acuminata Ruschka, 1924 rec. nov.; E. (P.) punctata Förster, 1859; Hydrorhoa johnheratyi Lotfalizadeh & Rasplus, sp. nov. and Stilbula cf. cyniformis (Rossi, 1792) are described and illustrated from Iran. Types of all related species have been examined and compared to the Iranian individuals. To stabilize existing nomenclature, we designated lectotypes and paralectotypes for E. (E.) adscendens and E. (E.) carinifera. The genus Hydrorhoa Kieffer, 1904 is confirmed to occur in the Palaearctic region. A key to the genera and species of Eucharitidae occurring in Iran, as well as their distribution maps, are provided.
The Birth of Time and Hesiod’s “Emotional Cosmos”. A Multiverse Approach amid Philosophical Instances and Philological Roots
Authors: Coco Emanuele 
Published: August 2022

Abstract
In his essay From Logos to Mythos, I republished on the twentieth anniversary of its first publication, Most saw in the release of Creuzer’s Symbolik und Mythologie the moment when philology distanced itself from philosophy “refraining strictly from any discussion of what the Greek myths could mean for us, and instead concentrating […] into what the Greek myths could have meant for the Greeks”. This essay analyses the case study offered by the mythological dyad Kronos (Κρόνος) and Chronos (Χρόνος). It highlights some elements that place these two figures at a distance on the philological level but closer on the philosophical one. The essay encourages a dialogue between philological rigour and philosophical use of myth: myth, in its prolificity, is eloquent in every age and a careful understanding of what it meant to the Greeks in its time does not necessarily imply giving up understanding what it may mean to us today.
A deep learning neural network approach for predicting the factors influencing heavy-metal adsorption by clay minerals
Authors: Liu Rui , Zuo Lei , Zhang Peng , Zhao Jiajia , Tao Dongping 
Published: August 2022

AbstractThe treatment of water containing heavy metals has attracted increasing attention because the ingestion of such water poses risks to human health. Due to their relatively large specific surface areas and surface charges, clay minerals play a significant role in the adsorption of heavy metals in water. However, the major factors that influence the adsorption rates of clay minerals are not well understood, and thus methods to predict the sorption of heavy metals by clay minerals are lacking. A method that can identify the most appropriate clay minerals for removal of a given heavy metal, based on the predicted sorption of the clay minerals, is required. This paper presents a widely applicable deep learning neural network approach that yielded excellent predictions of the influence of the sorption ratio on the adsorption of heavy metals by clay minerals. The neural network model was based on datasets of heavy-metal parameters that are available generally. It yielded highly accurate predictions of the adsorption rate based on training data from the dataset and was able to account for a wide range of input parameters. A Pearson sensitivity analysis was used to determine the contributions of individual input parameters to the adsorption rates predicted by the neural network. This newly developed method can predict the major factors influencing heavy-metal adsorption rates. The model described here could be applied in a wide range of scenarios.
DRASTIC, GOD, and SI approaches for assessing groundwater vulnerability to pollution: a review
Authors: Fannakh Abdelouahed , Farsang Andrea 
Published: August 2022

AbstractOver the last three to four decades, several methods for assessing groundwater vulnerability to anthropogenic pollution have been developed. Researchers and policymakers have widely used these methods for preventing groundwater pollution through knowledge about particularly vulnerable areas. This systematic review presents different and significant methods for assessing the vulnerability of aquifers for the protection of the resource. Previous studies mentioned that formulating a single technique for assessing groundwater vulnerability is difficult; thus, different methods and techniques have been proposed. Therefore, this paper presents three methods, namely, DRASTIC, GOD, and susceptibility index (SI), which will be discussed in detail, and highlights their advantages and limitations. In doing so, the study introduces the concept of aquifer vulnerability, and further discussion will be devoted to the three methods. Lastly, the study outlines the major challenges to the assessment of aquifer vulnerability. The review concludes the importance of groundwater vulnerability and strategies for preserving its quality.
Reducing costs for DNA and RNA sequencing by sample pooling using a metagenomic approach
Authors: Teufel Marc , Sobetzko Patrick 
Published: August 2022

AbstractDNA and RNA sequencing are widely used techniques to investigate genomic modifications and gene expression. The costs for sequencing dropped dramatically in the last decade. However, due to material and labor intense steps, the sample preparation costs could not keep up with that pace. About 80% of the total costs occur prior to sequencing during DNA/RNA extraction, enrichment steps and subsequent library preparation. In this study, we investigate the potential of pooling different organisms samples prior to DNA/RNA extraction to significantly reduce costs in preparative steps. Similar to the common procedure of ligated DNA tags to pool (c)DNA samples, sequence diversity of different organisms intrinsically provide unique sequences that allow separation of reads after sequencing. With this approach, sample pooling can occur before DNA/RNA isolation and library preparation. We show that pooled sequencing of three related bacterial organisms is possible without loss of data quality at a cost reduction of approx. 50% in DNA- and RNA-seq approaches. Furthermore, we show that this approach is highly efficient down to the level of a shared genus and is, therefore, widely applicable in sequencing facilities and companies with diverse sample pools.
Effects of visual scanning exercises in addition to task specific approach on balance and activities of daily livings in post stroke patients with eye movement disorders: a randomized controlled trial
Authors: Batool Sana , Zafar Hamayun , Gilani Syed Amir , Ahmad Ashfaq , Hanif Asif 
Published: August 2022

Abstract
Background
Impaired vision is one of the commonest and most disabling consequence following stroke. Among all visual impairments, eye movement disorders are found in 70% of stroke patients which include nystagmus, strabismus, gaze palsies, disconjugate eye movements and cranial nerve palsies. They have a wide ranging impact on balance and activities of daily livings by creating difficulties in maintaining normal alignment and appropriate movement of eyes. The purpose of this study was to examine the effects of visual scanning exercises in addition to task specific approach on balance and activities of daily livings in post stroke patients with eye movement disorders.

Methods
This study is a randomized controlled trial and was conducted in the University of Lahore Teaching Hospital from May 2019 to October 2020. A sample of 64 patients was recruited and randomly allocated into experimental and control group. 32 patients in experimental group were treated with visual scanning exercises along with task specific approach and 32 patients in control group were treated with task specific approach alone. Pre and post assessment of balance and activities of daily livings was assessed on BERG BALANCE SCALE and BARTHEL INDEX SCALE at baseline and at 4th week.

Results
Intra-group analysis of BERG BALANCE SCALE in experimental group showed statistically significant result (p < 0.05) in all items except in items 4, 13 and 14 respectively. Intra-group analysis of BERG BALANCE SCALE in control group showed statistically significant result (p < 0.05) in items 3, 5, 8 and 12 respectively, whereas remaining all items showed statistically insignificant result. Intra-group analysis of BARTHEL INDEX SCALE in experimental group showed statistically significant result in all items (p < 0.05) except in items 9 and 10 respectively. Intra-group analysis of BARTHEL INDEX in control group showed statistically significant result (p < 0.05) in items 1, 3, 4 and 8 respectively whereas remaining all items showed statistically insignificant result. Inter-group analysis showed statistically significant result in total scores of BERG BALANCE SCALE (p = 0.000) and BARTHEL INEX SCALE (p = 0.033).

Conclusion
Visual scanning exercises along with task specific approach were found to be more effective in comparison to task specific approach alone.

Trial registration
Trial registration number: [IRCT20190717044237N1], trial registration date: 10/11/2019,
Perceived general, mental, and physical health of Latinos in the United States following adoption of immigrant-inclusive state-level driver’s license policies: a time-series analysis
Authors: Escalera Cristian , Strassle Paula D. , Quintero Stephanie M. , Maldonado Ana I. , Withrow Diana , Alhomsi Alia , Bonilla Jackie , Santana-Ufret Veronica , Nápoles Anna María 
Published: August 2022

Abstract
Background
In the United States (U.S.), several states have laws that allow individuals to obtain driver’s licenses regardless of their immigration status. Possession of a driver’s license can improve an individual’s access to social programs, healthcare services, and employment opportunities, which could lead to improvements in perceived mental and physical health among Latinos living in the U.S.

Methods
Using Behavioral Risk Factor Surveillance System data (2011–2019) for Latinos living in the U.S. overall (immigration status was not available), we compared the average number of self-reported perceived poor mental and physical health days/month, and general health status (single-item measures) before (January 2011-June 2013) and after implementation (July 2015-December 2019) of immigrant-inclusive license policies using interrupted time-series analyses and segmented linear regression, and a control group of states in which such policies were not implemented. We also compared the average number of adults reporting any perceived poor mental or physical health days (≥ 1 day/month) using a similar approach.

Results
One hundred twenty-three thousand eight hundred seven Latino adults were included; 66,805 lived in states that adopted immigrant-inclusive license policies. After implementation, average number of perceived poor physical health days significantly decreased from 4.30 to 3.80 days/month (immediate change = -0.64, 95% CI = -1.10 to -0.19). The proportion reporting ≥ 1 perceived poor physical and mental health day significantly decreased from 41 to 34% (OR = 0.89, 95% CI = 0.80–1.00) and from 40 to 33% (OR = 0.84, 95% CI = 0.74–0.94), respectively.

Conclusions
Among all Latinos living in the U.S., immigrant-inclusive license policies were associated with fewer perceived poor physical health days per month and fewer adults experiencing poor physical and mental health. Because anti-immigrant policies can harm Latino communities regardless of immigration status and further widen health inequities, implementing state policies that do not restrict access to driver licenses based on immigrant status documentation could help address upstream drivers of such inequities.
Definitive surgery and intraoperative photodynamic therapy for locally advanced non-small cell lung cancer: a case report
Authors: Jung Hee Suk , Kim Hyun Jung 
Published: August 2022

Abstract
Background
There are no guidelines for straightforwardly managing advanced lung cancer (T3 or T4). Although surgery has traditionally been regarded as the mainstay treatment and the only curative modality, it has limited relevance for patients with locally advanced non-small cell lung cancer (NSCLC). Photodynamic therapy (PDT) is a clinically approved cancer therapy; it is an established treatment modality with curative intent for early-stage and superficial endobronchial lesions. However, the efficacy of PDT in advanced lung cancer is controversial, and it has primarily been used in palliative care.

Case presentation
This case report describes a 70-year-old male who had right upper lung cancer and an endobronchial lesion that extended into the distal trachea. A biopsy specimen was obtained upon bronchoscopy, and the result confirmed squamous cell carcinoma. We performed a definitive sleeve lobectomy and intraoperative PDT. Gross total resection of the tumor was achieved, but the presence of microscopic residual tumors was inevitable. Complete anatomical resection of the primary tumor by pneumonectomy was not possible due to poor lung function and endobronchial extension to the distal trachea. We decided to apply intraoperative PDT to the lumen and outer wall of the bronchi and distal trachea for local tumor control. The patient is alive with no evidence of disease after 13 months of follow-up.

Conclusions
This is the first report to describe the feasibility and efficacy of intraoperative PDT as part of multimodal therapy for locally advanced NSCLC.
Psychological stress induces depressive-like behavior associated with bone marrow-derived monocyte infiltration into the hippocampus independent of blood–brain barrier disruption
Authors: Hu Huiling , Yang Xue , He Yuqing , Duan Chaohui , Sun Nannan 
Published: August 2022

AbstractBackgroundPsychological stress is one of the most important factors that trigger emotional disorders, such as depression and anxiety. Emerging evidence suggests that neuroinflammation exacerbated by bidirectional communication between the peripheral immune system and the central nervous system facilitates abnormal psychiatric symptoms. This study aimed to investigate the hippocampal migration of bone marrow (BM)-derived monocytes and its role in regulating depressive-like behaviors using the chronic psychological stress (CPS) mouse model. More importantly, whether the central migration of these peripheral BM-derived cells depend on the disruption of the blood–brain barrier (BBB) was also investigated.Methods and findingsGreen fluorescent protein-positive (GFP+) BM chimeric mice were used to distinguish BM-derived monocytes within the brain. A CPS mouse model was established to explore the effect of CPS on hippocampal migration of BM-derived monocytes and its role in the regulation of depressive-like behaviors. The results revealed that BM-derived GFP+cells accumulated in the hippocampus and differentiated into microglia-like cells after exposure to CPS. Interestingly, this migration was not associated with BBB disruption. Furthermore, treatment with C–C chemokine receptor 2 (CCR2) antagonist (RS102895) suppressed the recruitment of BM-derived monocytes to the hippocampus and alleviated depressive-like symptoms.ConclusionThese findings indicate that monocyte recruitment to the hippocampus in response to psychological stress may represent a novel cellular mechanism that contributes to the development of depression.