bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanosecond pulsed discharge dynamics during passage of a transient laminar flame
Authors: Pavan Colin A , Guerra-Garcia Carmen 
Published: November 2022

Abstract
This work presents an experimental study of a nanosecond repetitively pulsed dielectric barrier discharge interacting with a transient laminar flame propagating in a channel of height near the quenching distance of the flame. The discharge and the flame are of comparable size, and the discharge is favoured at a location where it is coupled with the reaction zone and burnt gas. The primary goal is to determine how the discharge evolves on the time scale of the flame passage, with the evolution driven by the changing gas state produced by the moving flame front. This work complements the large body of work investigating the effect of plasma to modify flame dynamics, by considering the other side of the interaction (how the discharge is modified by the flame). The hot gas produced by the combustion had a strong effect on the discharge, with the discharge preferentially forming in the region of hot combustion products. The per-pulse energy deposited by the discharge was measured and found to increase with the size of the discharge region and applied voltage. The pulse repetition frequency did not have a direct impact on the per-pulse energy, but did have an effect on the morphology and size of the discharge region. Two distinct discharge regimes were observed: uniform and filamentary (microdischarges). Higher pulse repetition frequencies and faster-cooling combustion products were more likely to transition to the filamentary regime, while lower frequencies and slower-cooling combustion products maintained a uniform regime for the entirety of the time the discharge was active. This regime transition was influenced by the ratio of the time scale of fluid motion to the pulse repetition rate (with no noticeable impact caused by the reduced electric field), with the filamentary regime preferentially observed in situations where this ratio was small. This work demonstrates the importance of considering how the discharge properties will change due to combustion processes in applications utilizing plasma assistance for transient combustion systems.
Nonequilibrium plasma in water vapor
Authors: Tropina Albina , Shneider M N , Miles R B 
Published: November 2022

Abstract
A kinetic model of a non-equilibrium water vapor plasma created by a nanosecond pulsed discharge at elevated temperatures and at low pressure is presented. The model includes equations for electron, vibrational and gas temperatures combined with equations for neutral, charged, electronically and vibrationally excited species. Simulation results are compared with the available experimental data and show good agreement in dynamics of the plasma decay and electron drift velocities. It is shown that the plasma decay in pure water vapor is controlled by the dissociative recombination. Under the conditions simulated, the concentration of electronically excited species is low, but we observe a formation of vibrationally excited species. A significant decrease in the electrical conductivity of water plasma with time, which depends on the level of initial ionization, is shown.
Gravitational waves in f(R, T)-rainbow gravity: even modes and the Huygens principle
Authors: Aydogdu O , Salti M 
Published: November 2022

Abstract
In the context of f(R, T)-gravity, propagation of gravitational waves (GWs) for even (or polar) modes is explored by using the Regge-Wheeler gauge in the conformally flat Friedman-Lemaitre-Robertson-Walker type rainbow (CFR) universe. Writing the perturbed field equations for the polar GWs in the CFR spacetime, we first acquire a second-order differential equation for one of the unknown perturbation factors and then get all other unknown perturbation functions. Withal, we reach a conclusion that both the four-velocity vector components except the third one and the corresponding matter distribution are affected by the polar perturbation. Furthermore, the effect of rainbow functions, which can change the geometry of space-time, on the polar GWs is also analyzed graphically. We achieve that the shape (wavelength and amplitude) of polar GWs is dramatically impressed by the alteration of rainbow functions. Lastly, we investigate whether the polar GWs satisfy the Huygens principle.
Proteolytic and mechanical remodeling of the extracellular matrix by invadopodia in cancer
Authors: Perrin L , Gligorijevic B 
Published: November 2022

Abstract
Cancer invasion and metastasis require remodeling of the adjacent extracellular matrix (ECM). In this mini review, we will cover the mechanisms of proteolytic degradation and the mechanical remodeling of the ECM by cancer cells, with a focus on invadopodia. Invadopodia are membrane protrusions unique to cancer cells, characterized by an actin core and by the focal degradation of ECM via matrix metalloproteases (MMPs). While ECM can also be remodeled, at lower levels, by focal adhesions, or internal collagen digestion, invadopodia are now recognized as the major mechanism for MMP-dependent pericellular ECM degradation by cancer cells. Recent evidence suggests that the completion of epithelial-mesenchymal transition may be dispensable for invadopodia and metastasis, and that invadopodia are required not only for mesenchymal, single cell invasion, but also for collective invasion. During collective invasion, invadopodia was then shown to be located in leader cells, allowing follower cells to move via cooperation. Collectively, this suggests that invadopodia function may be a requirement not only for later steps of metastasis, but also for early invasion of epithelial cells into the stromal tissue. Over the last decade, invadopodia studies have transitioned into in 3D and in vivo settings, leading to the confirmation of their essential role in metastasis in preclinical animal models. In summary, invadopodia may hold a great potential for individual risk assessment as a prognostic marker for metastasis, as well as a therapeutic target.
Low-lying state investigations of odd-A Mn isotopes around N = 28
Authors: Ye Huanyi , Li Jian , 李 剑 , Yang Dong , Jin Hua , Huang Xiaolong 
Published: November 2022

Abstract
Based on the systematic studies for low-lying states of the odd-A
49−57Mn isotopes, the ground-states inversion and the rotational properties of a ground-state-based sequence are revealed and discussed. The energy levels of low-lying states and electromagnetic moments in odd-A
49−57Mn isotopes have been well reproduced in shell-model calculations, and the above phenomena could be understood with obviously different occupation numbers in proton orbitals such as π
f
7/2 and π
p
3/2, which changes similarly with the obtained quadrupole deformation in covariant density functional theory (CDFT). After considering the coupling of collective rotation and intrinsic single-particle motion, the available experimental magnetic moments in 53Mn and adjacent nuclei can be well explained with CDFT. The present calculations suggest that the 5/2− and 7/2− states in 53Mn are formed by π5/2−[312] and π7/2−[303] respectively. Together with the behavior of levels, this provides proofs for the level sequences of low-lying states in 53Mn distinct from the K

π
= 5/2− rotational band in 49Cr and other odd-A Mn isotopes.
Simulating lattice quantum electrodynamics on a quantum computer
Authors: Kan Angus , Nam Yunseong 
Published: November 2022

Abstract
U(1) lattice gauge theories (LGTs) offer a way to simulate quantum electrodynamics, one of the three forces unified by the Standard Model of particles physics. Here we provide complete, quantum-gate-by-quantum-gate algorithms to simulate U(1) LGTs on a fault-tolerant quantum computer. We further perform rigorous error analysis in order to derive concrete estimates of the quantum computational resources required for an accurate simulation of U(1) LGTs using a second-order product formula. We show that U(1) LGTs in any spatial dimension can be simulated using

O
˜

(

T

3
2

N

3
2

Λ

ϵ

−

1
2

)

non-Clifford T gates, where T is the simulation time, N is the number of lattice sites, Λ is the truncation parameter for the bosonic gauge fields, and ε is the simulation error. This work paves the way towards fault-tolerant quantum simulations of physical models closely related to the Standard Model of particle physics.
A novel humanized Chi3l1 blocking antibody attenuates acetaminophen-induced liver injury in mice
Authors: Li Leike , Wen Yankai , Wrapp Daniel , Jeong Jongmin , Zhao Peng , Xiong Wei , Atkins Constance Lynn , Shan Zhao , Hui Deng , McLellan Jason S , Zhang Ningyan , Ju Cynthia , An Zhiqiang 
Published: November 2022

Abstract
Acetaminophen (APAP) overdose is a leading cause of acute liver injury in the USA. The chitinase 3-like-1 (Chi3l1) protein contributes to APAP-induced liver injury (AILI) by promoting hepatic platelet recruitment. Here, we report the development of a Chi3l1-targeting antibody as a potential therapy for AILI. By immunizing a rabbit successively with the human and mouse Chi3l1 proteins, we isolated cross-reactive monoclonal antibodies (mAbs) from single memory B cells. One of the human and mouse Chi3l1 cross-reactive mAbs was humanized and characterized in both in vitro and in vivo biophysical and biological assays. X-ray crystallographic analysis of the lead antibody C59 in complex with the human Chi3l1 protein revealed that the kappa light contributes to majority of the antibody–antigen interaction; and that C59 binds to the 4α-5β loop and 4α-helix of Chi3l1, which is a functional epitope and hotspot for the development of Chi3l1 blocking antibodies. We humanized the C59 antibody by complementarity-determining region grafting and kappa chain framework region reverse mutations. The humanized C59 antibody exhibited similar efficacy as the parental rabbit antibody C59 in attenuating AILI in vivo. Our findings validate Chi3l1 as a potential drug target for AILI and provide proof of concept of developing Chi3l1 blocking antibody as a therapy for the treatment of AILI.
Safety of Helium-based Plasma Technology for Coagulation of Soft Tissue: A Retrospective Review
Authors: Shridharani Sachin M , Kennedy MacKenzie L 
Published: November 2022

Abstract

Background
The subdermal application of energy using a helium-based plasma radiofrequency (RF) device has been shown to improve skin laxity. Helium-based plasma RF technology (Renuvion; Apyx Medical, Clearwater, FL) utilizes RF to ionize helium into an electrically conductive plasma capable of coagulating and contracting soft tissue with high precision and minimal thermal spread. This study provides information on the early use of the new generation of electrosurgical generator (APYX-RS3) containing a feature that allows for quantification of the amount of energy delivered to tissue during treatments.

Objectives
To collate procedure details, treatment settings, and safety data in patients treated with a helium-based plasma device for soft tissue coagulation.

Methods
A retrospective review was conducted of patients aged ≥ 18 years who underwent treatment with a helium-based plasma RF device (Renuvion) for soft tissue coagulation. Demographic data, procedure details, and adverse events were collected.

Results
Chart review identified 47 patients with an average age of 45 years and an average BMI of 25.8 kg/m2. The amount of energy (J) delivered per treatment area was greatest for abdomen, buttocks, and thighs, with an average of 13.7 kJ, 13.5 kJ, and 10.6 kJ, respectively. No serious, unexpected, or device-related AEs were reported.

Conclusions
The use of the generator that quantifies the energy (joules) being applied during the procedure allows the provider to understand and optimize their energy usage. While further research is needed to establish the safety and efficacy of the device for skin tightening, this study provides important information regarding energy application.

Level of Evidence: 4
Clarion is a multi-label problem transformation method for identifying mRNA subcellular localizations
Authors: Bi Yue , Li Fuyi , Guo Xudong , Wang Zhikang , Pan Tong , Guo Yuming , Webb Geoffrey I , Yao Jianhua , Jia Cangzhi , Song Jiangning 
Published: November 2022

Abstract
Subcellular localization of messenger RNAs (mRNAs) plays a key role in the spatial regulation of gene activity. The functions of mRNAs have been shown to be closely linked with their localizations. As such, understanding of the subcellular localizations of mRNAs can help elucidate gene regulatory networks. Despite several computational methods that have been developed to predict mRNA localizations within cells, there is still much room for improvement in predictive performance, especially for the multiple-location prediction. In this study, we proposed a novel multi-label multi-class predictor, termed Clarion, for mRNA subcellular localization prediction. Clarion was developed based on a manually curated benchmark dataset and leveraged the weighted series method for multi-label transformation. Extensive benchmarking tests demonstrated Clarion achieved competitive predictive performance and the weighted series method plays a crucial role in securing superior performance of Clarion. In addition, the independent test results indicate that Clarion outperformed the state-of-the-art methods and can secure accuracy of 81.47, 91.29, 79.77, 92.10, 89.15, 83.74, 80.74, 79.23 and 84.74% for chromatin, cytoplasm, cytosol, exosome, membrane, nucleolus, nucleoplasm, nucleus and ribosome, respectively. The webserver and local stand-alone tool of Clarion is freely available at http://monash.bioweb.cloud.edu.au/Clarion/.
Simultaneous Determination of the Content of Isoimperatorin, Imperatorin, Oxypeucedanin, Xanthotoxol and Byakangelicin in Angelica dahurica by HPTLC Scanning
Authors: Yang Hanting , Li Qian 
Published: November 2022

Abstract
In this study, we established a new rapid, simple and low cost method for the determination of coumarin components in Angelica dahurica using high-performance thin-layer chromatography (HPTLC) based on the standards of the Chinese Pharmacopoeia for the analysis of isoimperatorin, imperatorin, oxypeucedanin, xanthotoxol and byakangelicin. The coumarins in A. dahurica were extracted with solvent methods, and linear ascending development was carried out in a twin trough glass chamber saturated with petroleum ether-ethyl acetate (3:2, v/v). The plate was dried and analyzed by HPTLC scanner at 254 nm. The five coumarin components have achieved good separation, clear and satisfactory resolution with the Rf values of 0.84, 0.69, 0.64, 0.57 and 0.19 for isoimperatorin, imperatorin, oxypeucedanin, xanthotoxol and byakangelicin, respectively. The content of five coumarins were 0.282, 0.626, 0.393, 0.066 and 0.144, respectively. In addition, the calibration range was constructed in the range 0.8-4.0 μg/spot; the limit of detection and limit of quantification, precision, repeatability and recovery were stably and good. This study indicated that the HPTLC scanning could be used for the determination of multiple components in A. dahurica.
Great Power Rivalry and Hedging: The Case of AIIB Founding Members
Authors: Jang Woojeong 
Published: November 2022

Abstract
Why did some states join the Asian Infrastructure Investment Bank (AIIB), overriding the US opposition, while others did not? Are they balancing against the USA and accommodating China? Characterizing the joining of the AIIB as a case of hedging, this study unearths the political calculus behind hedging amidst great power rivalry. Placing my argument within a relational-network approach, I argue that states deeply embedded in the dominant international order are more likely to join the AIIB to hedge. First, the fear of abandonment is lower for highly embedded states due to their significance in the international order. Second, the fear of domination is also lower for states with extensive network ties; they can use their social and political power to voice their demands, mobilize other states, and earn policy concessions. Hence, I expect hedging to be a strategy of core states instead of second-tier or rogue states. I test the hypothesis with a large-N analysis using an original dataset on states’ embeddedness in the US-led order and comparative case studies of the UK and Ireland.
De novowhole-genome assembly in an interspecific hybrid table grape, ‘Shine Muscat’
Authors: Shirasawa Kenta , Hirakawa Hideki , Azuma Akifumi , Taniguchi Fumiya , Yamamoto Toshiya , Sato Akihiko , Ghelfi Andrea , Isobe Sachiko N 
Published: November 2022

AbstractThe first genome sequence of an interspecific grape hybrid (Vitis labruscana × Vitis vinifera), ‘Shine Muscat’, an elite table grape cultivar bred in Japan, is presented. The resultant genome assemblies included two types of sequences: a haplotype-phased sequence of the highly heterozygous genomes and an unphased sequence representing a ‘pseudo-haploid’ genome. The unphased sequences, assembled to the chromosome level with Hi-C reads, spanned 488.97 Mb in length, 99.1% of the estimated genome size, with 4,595 scaffold sequences and a 23.9-Mb N50 length. The phased sequences had 15,650 scaffolds spanning 1.0 Gb and a 4.2-Mb N50 length. 32,827 high-confidence genes were predicted on the unphased genomes. Clustering analysis of the ‘Shine Muscat’ gene sequences with three other Vitis species and Arabidopsis indicated that 11,279 orthologous gene clusters were common to Vitis spp. and Arabidopsis, 4,385 were Vitis specific, and 234 were ‘Shine Muscat’ specific. Whole-genome resequencing was also performed for the parental lines of ‘Shine Muscat’, Akitsu-21 and ‘Hakunan’, and parental-specific copy number variations were identified. The obtained genome resources provide new insights that could assist in cultivation and breeding strategies to produce high-quality table grapes.
Serial observation of PK Papyrus covered stent implantation for coronary artery perforation by optical coherence tomography and coronary angioscopy: a case report
Authors: Ishiguro Nobuo , Aoyama Hidekazu , Kametani Ryosuke 
Published: November 2022

Abstract

Background
Coronary artery perforation is a rare but life-threatening complication of percutaneous coronary intervention. We present a case of coronary artery perforation treated with a PK Papyrus covered stent. Neointimal coverage evaluation was performed using optical coherence tomography (OCT) and coronary angioscopy (CAS) at 3 and 9 months after stent implantation.

Case summary
A 63-year-old man was admitted to our hospital with worsening effort angina over 3 months. Coronary angiography revealed severe stenosis in the proximal segment of the left anterior descending artery. After stent implantation, coronary artery perforation occurred. We immediately sealed the perforation site using a PK Papyrus covered stent. The patient was discharged on postoperative day 4. OCT and CAS revealed incomplete neointimal coverage at the PK Papyrus covered stent strut 3 months after stent implantation. At 9 postoperative months, complete neointimal coverage was observed. We continued clopidogrel and edoxaban, but no clinical adverse events were encountered during the follow-up.

Discussion
To the best of our knowledge, this is the first report of a serial observation of PK Papyrus covered stent implantation for coronary artery perforation using OCT and CAS. In this case, OCT and CAS revealed complete neointimal coverage, without obvious thrombus, 9 months after PK Papyrus implantation. Based on the OCT and CAS findings, our report presents an appropriate follow-up strategy for the prevention of stent thrombosis when using a PK Papyrus covered stent, which will contribute to future research on the appropriate duration of dual antiplatelet therapy and evaluation of neointimal coverage.
Leaflet fracture and escape from an On-X mechanical mitral valve in a child: a case report
Authors: Uthayakumaran Gajon , Finucane Kirsten , Gentles Thomas , Mitchelson Bryan 
Published: November 2022

Abstract

Background
Leaflet escape is a rare complication of mechanical heart valves. The following case is the first report of leaflet escape from an On-X mechanical mitral valve in a child.

Case summary
A 12-year-old boy presented with acute pulmonary oedema one year after mitral valve replacement with an On-X valve for rheumatic heart disease. Transoesophageal echocardiogram diagnosed an absent mechanical mitral valve leaflet and severe mitral regurgitation for which the patient successfully underwent urgent mitral valve replacement. Computed tomography located fragments of the embolised mitral valve leaflet at the bifurcation of the abdominal aorta and within the right common iliac artery. In the absence of impaired lower limb perfusion, the leaflet fragments were left in situ. He was discharged without complication and remains asymptomatic three months post-discharge.

Discussion
Leaflet fracture and escape is a known but rare complication of mechanical valve prostheses. The first-line investigation for suspected mechanical valve dysfunction is transoesophageal echocardiogram which elicited the diagnosis on this occasion.
Illness perceptions and health literacy are strongly associated with health-related quality of life, anxiety, and depression in patients with coronary heart disease: results from the EUROASPIRE V cross-sectional survey
Authors: Jennings C S , Astin F , Prescott E , Hansen T , Gale Chris P , De Bacquer D 
Published: November 2022

Abstract

Aims
To (1) Describe the sociodemographic and risk factor profiles of a sample of patients with coronary disease, (2) Explore associations between illness perceptions and health literacy with sociodemographic characteristics and risk factors, health-related quality of life (HRQoL), anxiety, and depression.

Methods and results
Conducted as part of the ESC Prevention of CVD Project and EUROASPIRE V survey, patients were consecutively and retrospectively identified 6 months to 2 years after an acute event or elective procedure from 12 countries and interviewed. Three thousand four hundred and eight participants (76% male, mean age 64 years) were recruited, 16% were smokers, 38% obese, 60% physically inactive, and 41% hypertensive. Forty percent had attended cardiac rehabilitation. More threatening illness perceptions were associated with female gender (P &lt; 0.0001), lower income (P &lt; 0.0001), lower education (P = 0.02), obesity (P &lt; 0.0001), sedentary behaviour (P &lt; 0.0001), and diabetes (P &lt; 0.0001). Poorer health literacy was associated with obesity (P = 0.02) and sedentary behaviour (P = 0.0001). Threatening illness perceptions were strongly associated with anxiety, depression, and poorer ratings of HRQoL after multivariable adjustment (all P &lt; 0.001). Poor health literacy was associated with anxiety and depression (P &lt; 0.0001) and poorer ratings of HRQoL (HeartQol scores P = 0.03). Results were consistent across regions of Europe, age, gender, and socio-economic strata.

Conclusions
Interventions like cardiac rehabilitation should be targeted at vulnerable groups given the strong associations between more threatening illness perceptions, lower health literacy, lower HRQoL, and higher levels of anxiety and depression. The delivery and content of these interventions should be accessible for those with low health literacy.