bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Newcomer Well Woman Clinic: A Cross-Sectional Evaluation of an Innovative Care Model to Support the Sexual and Reproductive Health Needs of Refugee Women
Authors: Sivakumar Aditi , Willows Karla , Maguire Finlay , Stairs Jocelyn 
Published: December 2022

Abstract

Background: The Newcomer Well Woman Clinic (NWWC) was developed as a partnership between primary care physicians and obstetrics and gynecology residents to ensure timely provision of sexual and reproductive healthcare for refugee patients. Since 2015, the NWWC has provided monthly clinics offering contraceptive counselling, cervical cancer screening, and intrauterine device insertions with accompanying education sessions. This study aimed to evaluate women’s experiences at the clinic and with interpretation services.
Methods: A sample of patients who attended appointments at the NWWC between January 2015-December 2020 were invited to participate in a telephone survey facilitated by an interpreter to evaluate their clinic experience. The survey was adapted from two validated survey measures: the PSQ-18 and CAHPS. Survey results were reported using descriptive statistics. Clinic audit data was used to summarize patient demographics and service delivery during this period.
Results: Since 2015, 288 patients have attended the clinic. Despite the COVID-19 pandemic, the number of appointments increased annually. 76% of eligible invitees consented to participate. Most patients were highly satisfied (74%) or satisfied (10%) with their care and found the education sessions helpful (80%). Frequently requested education topics included cervical cancer prevention (54%) and contraception (36%). 80% of patients used an interpreter at the clinic and 88% felt that their concerns were always conveyed appropriately to the physician.
Conclusion: Refugee patients were highly satisfied by the sexual and reproductive healthcare provided by the NWWC and with interpretation services. To meet the needs of refugees, innovative care models such as the NWWC could be adopted by healthcare systems.
Investigating the relationship between meteorological and hydrological drought for present and future using the in the semi-arid basins using SWAT model based on Climate Change Toolkit (CCT)
Authors: Mokhtari Fahimeh , Honarbakhsh Afshin , Soltani Saeed 
Published: December 2022

Abstract

Water resources are strongly affected by periods of low rainfall. Previous studies have rarely examined the association between meteorological and hydrological droughts in the future. In this paper, SPEI and SRI indices for the base period (1991–2019) were calculated. By introducing the microscale results of 5 climate models in the CCT program under RCP 2.6 and RCP8.5 scenarios to the SWAT model, SPEI and SRI indices were simulated for the near future (2043 to 2071) and the distant future (2072 to 2100). Then, in both the baseline period and in the future, the correlation between these two indices in the periods of 3, 6 and 12 months was examined using Pearson coefficient. Finally, the Pearson correlation was utilized to analyze the relationship between meteorological drought and the time of hydrological drought between the SPEI index of each period with the SRI index within the same period and for a lag time of one, two, three and four months. The results of the correlation between the two drought indices showed that both in the baseline period and in the future; there was the greatest significance between the hydrological and meteorological drought indices of 12 months. The results of delays in most stations showed that the highest correlation was observed between 12-month SPEI and 12-month SRI with 3 to 4 months delay. Knowing the time interval between the occurrence of meteorological drought and other droughts helps managers to take the necessary management measures to deal with drought.
Non-POU Domain-Containing Octomer-Binding (NONO) protein expression and stability promotes the tumorigenicity and activation of Akt/MAPK/β-catenin pathways in human breast cancer cell Running title: NONO promotes the tumorigenicity of breast cancer
Authors: Lone Bilal Ahmad , Siraj Fouzia , Sharma Ira , Verma Shweta , Karna Shibendra Kumar Lal , Ahmad Faiz , Nagar Preeti , Sachidanandan Chetana , Pokharel Yuba Raj 
Published: December 2022

Abstract
Breast cancer is one of the most common cancers with high mortality, highlighting the vital need to identify new therapeutic targets. Here we report that Non-POU Domain-Containing Octamer-Binding (NONO) Protein is overexpressed in breast cancers and validated the interaction of WW domain of PIN1 with c-terminal Threonine-Proline (thr-pro) motifs of NONO. The interaction of NONO with PIN1 enhances NONO’s stability by inhibiting its proteasomal degradation, and this identifies PIN1 as a positive regulator of NONO to promote breast tumor development. Functionally, silencing of NONO inhibits the growth, survival, migration and invasion, epithelial-to-mesenchymal transition (EMT), and stemness of breast cancer cells in vitro. A human metastatic breast cancer cell xenograft was established in transparent zebrafish (Danio rerio) embryos to study the metastasis inability of NONO silenced breast cancer cells in vivo. Biochemical analysis indicated NONO as a master regulator of the molecules associated with different hallmarks of cancer. Mechanistically, depletion of NONO promotes the expression of PDL1 cell surface protein in breast cancer cells. The identification of novel interactions of NONO with c-Jun and β-catenin proteins and activating the Akt/MAPK/β-catenin signalling suggests NONO as novel regulator of Akt/MAPK/β-catenin signalling pathways. Taken together, our results demonstrated an essential role of NONO in the tumorigenicity of breast cancer and could be a potential target for anti-cancerous drugs.
Effect of phosphotungstic acid on surface properties and bond strength of resin cement to zirconia
Authors: Metwaly Menntallah , Al-Zordk Walid , El-Dafrawy Shady , Dawood Lamia 
Published: December 2022

Abstract
Background
The purpose of this in vitro study was to evaluate the effect of phosphotungstic acid pre-treatment on the surface properties of zirconium oxide ceramics and the microtensile bond strength (µTBS) between zirconium oxide ceramics and resin cement.
Methods
A total of 26 sintered zirconia blocks were randomly divided according to surface pre-treatment into four groups; group C (n = 6): no treatment (control), group S (n = 6): air-borne particle abrasion followed by Silano Pen treatment, group P1 (n = 7): Phosphotungstic acid 1gm/ 50 mL, and group P2 (n = 7): Phosphotungstic acid 2gm/50 mL. From each group, one zirconia block was examined using X-Ray Diffraction and scanning electron microscope. Also, one zirconia block from groups P1 and P2 was examined using Fourier-transform infrared spectroscopy. A total of 20 zirconia blocks were bonded to corresponding pre-constructed composite blocks using adhesive resin cement. Each zirconia-composite assembly was sectioned to obtain microbars of 1 mm2. A 20 microbars from each group were selected and aged (3500 thermocycles between 5°C and 55°C), then the µTBS test was performed using a universal testing machine (0.5 mm/min). The µTBS results was analyzed using one-way ANOVA test.
Results
Group P2 recorded the highest µTBS (23.824 ± 5.9 MPa) between all studied groups, while Group C recorded the lowest µTBS (12.19 ± 4.67 MPa). One-way ANOVA revealed a significant difference (P < 0.05) between all groups. The mode of failure was predominantly adhesive in Groups C, P1, and S, while group P2 showed cohesive and adhesive failures.
Conclusions
The phosphotungstic acid (2gm/50 mL) improved the bond strength of zirconia ceramics without phase transformation and composition changes.
Knowledge and Practices Regarding the Prevention Principles of Covid-19 Among Third Year Degree Nursing Students at a University Khomas Region, Namibia
Authors: Nyanya Tulela Phophy Tuna-tate , Kadhila Joseph Galukeni 
Published: December 2022

Abstract
Background:The rapid spread of SARS-CoV-2 is responsible for the global pandemic. Since the outbreak of COVID-12 began, necessary measurements and policies were provided to the public for prevention of the transmission of the disease. This measures and polies included: mandatory wearing of a mask in public, social distancing, regular hand sanitizing, and avoidance of overcrowded places etc. This study assessed the knowledge and practices regarding the prevention principles of covid-19 among third year degree nursing students at a University Khomas region, Namibia.
Methods: A quantitative study was conducted on 77 study population and participants who were chosen using simple random sampling. The data was collected with the use of questionnaires. A pilot study was done on 5 participants to assess reliability of the data collection tool/questionnaire, or if there would be any changes that have to be made in the questionnaires and to note down time spent on answering the questionnaires. Data was analyzed with Microsoft excel version and descriptive analysis. The findings are presented in pie charts, bar graph and tables.
Results:The findings showed that, most of the students 91% have good knowledge and practices regarding the prevention principles of OVID-19. Although the findings indicated overall good knowledge and good practices regarding applications of the preventive principles for COVID-19, the findings nevertheless indicated that 71% of the participants had average knowledge, 23,4% had poor knowledge while, 90% had average practices and 32% had poor practice regarding applications of the preventive principles for COVID-19. Out of the 77 participants, only 1% of the student know that COVI-19 is disease and the whole 99% don’t know which, apart from that poor knowledge, 25 participants from the 77, think getting vaccinated will prevent getting infected by COVID-19, but it only reduces getting infected.
Conclusion:Some knowledge and practice gaps were identified about the students not having average or poor knowledge whether COVID-19 is a disease or virus and that getting vaccinated prevent one from getting infected or reduce the risk of getting infected. Apart from that, third year nursing degree students have good knowledge and practices on COVID-19 prevents
Ultra-stable radioactive microspheres enabled by radiation-induced graft polymerization for imaging-guided intra-arterial brachytherapy
Authors: Xu Xiao , Chen Hu , Wang Yangjie , He Pan , Zhao Zhenwen , Cheng Hongwei , Gao Xing , Shi Yesi , Li Yesen , Huang Jinxiong , Peng Yisheng , Chu Cheng-Chao , Zhang Yang , Liu Chao , Li Bo , Mao Jingsong , Ma Hongjuan , Liu Gang 
Published: December 2022

Abstract
Intravascular brachytherapy requires advances in radio-embolization technologies that combine brilliant radiostability efficacy with a facile and green synthesis route. We report a hybrid-integrated radioactive microsphere strategy using phosphorylcholine-modified lutetium-177 coordinated polymeric microspheres (177Lu-PCMs) that were fabricated via radiation-induced graft polymerization for imaging-guided locoregional intravascular brachytherapy. The underlying formation mechanism of 177Lu-PCMs is elucidated using first-principles computations and density functional theory calculations and 177Lu loading mechanisms was investigated with Near-edge and extended X-ray absorption fine structure spectroscopy. The engineered 177Lu-PCMs exhibit excellent mechanical properties, good hydrophilicity, and controlled sphere diameter. These features provide advantages of ultra-stable and ultra-selective embolic radio-theranostics, which is demonstrated in different preclinical rodent models and isolated human liver tumor tissues. During locoregional intra-arterial brachytherapy, 177Lu-PCMs can be visualized via SPECT to validate the in vivo biodistribution and retention in real time, achieving precise delivery, effective anti-cancer treatment, and a distinguished safety profile without degradation, ectopic embolization, and adverse reactions. Therefore, this study may offer a new avenue for the development of a highly innovative and translational approach for precision intravascular brachytherapy.
Manganese dioxide coated cotton fabric decorated with palladium nanoparticles for oxidation of alcohols, oxidative deprotection of oximes and degradation of methyl orange
Authors: Sharma Surbhi , Sharma Vrinda , Choudhary Anu , Sharma Sukanya , Paul Satya 
Published: December 2022

Abstract
The development of novel bio-based heterogeneous catalytic systems with easy separation and recyclability is significant in chemical synthesis. In this work, palladium nanoparticles have been successfully anchored on to the surface of MnO2 modified cotton fabric via a facile method for the synthesis of Pd(0)@MnO2-CF catalyst. Several characterization methods including FEG-SEM, EDX, XRD, FTIR, TGA, ICP-AES and XPS were used to confirm the immobilization of Pd NPs onto the cotton fabric. The catalytic activity of synthesized catalyst, Pd(0)@MnO2-CF, was evaluated for oxidation of alcohols, oxidative deprotection of oximes and degradation of methyl orange for which it demonstrated good activity. Besides, easy separation of the catalyst from the reaction mixture is one of its major advantages as it eliminates the need to employ other tedious work-up procedures. Further, the reusability of Pd(0)@MnO2-CF was studied by performing oxidation of 4-bromobenzyl alcohol and oxidative deprotection of 4-bromobenzaldehyde oxime consecutively for five times and a minor loss in catalytic activity was observed.
Performance of creatinine and cystatin C-based equations for GFR estimation in children with pre-dialysis chronic kidney disease.
Authors: Dawman Lesa , Rawat Amit , Tiewsoh Karalanglin , Meena Jitendra 
Published: December 2022

Abstract
Background: Numerous equations have been reported for the estimation of glomerular filtration rate (eGFR) based on serum creatinine. Serum cystatin C-based equation has been recently demonstrated to be better in estimating GFR. This study was conducted to examine the agreement between eGFR measured by equations based on serum creatinine (eGFRCr) and cystatin C (eGFRCys) or both (eGFRCrCys) in children with chronic kidney disease (CKD).
Methods: This prospective observational study was conducted in children less than 14-years with CKD stage 2-4. CKiD equation was used for calculation of eGFRCr and eGFRCys. Considering the eGFRCr as reference standard, we assessed the agreement of eGFRCr with eGFRCys and eGFRCrCys estimated by constructing a Bland-Altman plot and visually estimating the distribution of points representing the difference between eGFRCr and eGFRCys or eGFRCrCys against the line of zero difference.
Results: A total of 60 patients (54 boys) with mean age of 88±47 months were enrolled. Overall, 57%, 35% & 8% children had CKD stage 2, 3, and 4 respectively. The mean eGFRCr, eGFRCys and eGFRCrCys was 58 (19), 55 (21) and 62 (12) ml/min/1.73 m2, respectively. Bias between eGFRCr and eGFRCys was 2.8 (95% CI: -1.03 to 6.6) ml/min/1.73 m2. Bias between eGFRCr and eGFRCrCys was -4.5(95% CI: -6.5 to -2.5) ml/min/1.73 m2.
Conclusion: Serum creatinine-based equation slightly overestimates the GFR when compared with eGFRCrCys with overall average agreement between equations in children with pre-dialysis CKD. For GFR estimation, the combination of serum creatinine and serum cystatin C is more precise than either marker alone.
The June 2022 Afghanistan earthquake M W 6.2: Tectonic implications and Coulomb stress change
Authors: Baruah Santanu , Dey Chandan , Chetia Timangshu , Saikia Sowrav , Molia Nabajyoti , Borthakur Prachurjya , Hazarika Devajit , Kayal J R 
Published: December 2022

Abstract
The June 21, 2022 strong earthquake Mw 6.2 occurred nearly 165 km southeast of Kabul city, Afghanistan, and caused more than 1000 casualties and huge property losses. An untimely occurrence of the shallow focus event (~ 10 km, USGS report) at mid-night when people were asleep and the poor constructed houses caused so many casualties. It is one of the most devastating earthquake in Afghanistan in the recent years. The GCMT solution shows a strike-slip faulting at a centroid depth ~ 15 km; the NNE-SSW nodal plane is comparable with the trend of Chaman-Gardez fault system, though the eipcenter is ~ 50 km away from the surface fault traces. Afghanistan is under tectonic stresses from the Hindu-Kush collision zone to the north, Makran subduction zone to the south and from the transpressional zones to the east and west. Stress inversion study shows a NNW-SSE compressional stress and NNE-SSW extensional stress in the study area, the central intra-plate zone of Afghanistan. A seismic cross section of the main shock, aftershocks and the past events shows shallow near vertical source zones. The aftershock trend and the maximum PGA trend are parallel to the Chaman-Gardez fault system. Coulomb stress-change images after the main shock show that the aftershocks occurred in the increased stress zone of the rupture area.
Alternative samples for Porcine Reproductive and Respiratory Syndrome surveillance in an endemic PRRSV-1 infected breeding herd: a descriptive study
Authors: LEBRET Arnaud , NORMAND Valérie , BERTON Pauline , NICOLAZO Théo , TEIXEIRA-COSTA Charlotte , CHEVANCE Céline , BRISSONNIER Mathieu , BOULBRIA Gwenaël 
Published: December 2022

Abstract

Knowing PRRSV status is essential to design herd management protocols. For this, weaning-age pigs are a key subpopulation. In the last years, several alternatives to blood sampling have been tested because of easier, welfare friendly and cost saving tools. Moreover, most of them allow to test more animals and then, seem to be more sensitive in case of low prevalence scenario. However, these studies have been implemented mainly in PRRSV-2 infected herds. The first objective of our study was to compare the rate of detection of PRRSV-1 by RT-qPCR in individual serum samples, family oral fluid samples (FOF) and udder wipes (UW) collected the day before weaning. The second objective was to evaluate the interest of pooling. The study was performed on a 200-sows farrow-to-finish farm, PRRSV-1 infected and unstable. 119 litters were sampled (one sample type per litter). The rate of detection of PRRSV-1 in blood samples, FOF and UW was 10.9%, 7.6% and 0.8%, respectively. The agreement between sera and FOF was almost perfect even if detection capacity of sera was numerically superior to FOF. The Ct values on sera were statistically lower than FOF ones. Two modalities of pooling (1/3 and 1/5) were tested for sera and FOF. They showed that both modalities did not impact the qualification neither of the litter not of the batch PRRSV classification. On the other hand, even pooled by 3, most of the FOF pools gave negative results misclassifying many litters and batches. In the conditions of our study, in a PRRSV-1 infected scenario, FOF seemed to be a good alternative to blood sampling only when analysed individually and so a more costly alternative.
Hand Gesture Recognition System for Controlling VLC Media Player Based on Two Stream Transfer Learning
Authors: Patil Anjali , Patil Shilendra 
Published: December 2022

Abstract
The hand gesture recognition (HGR) is one of the most prominent cogent in machine learning and computer vision applications. This paper implements an application of HGR which is designed for human computer interaction using deep learning based two stream transfer learning for controlling the VLC media player. The aim and objectives of this application are to use a natural device free interface, which recognizes hand gestures as commands. The application uses a webcam which is used for image acquisition. To control the VLC media player using defined gesture, the application focuses on some function of VLC which are used more frequently such as play, pause, and stop. In order to incorporate this, a decision fusion based system using the transfer learning architectures is proposed to achieve the said task. Two pretrained models namely ‘MobileNet’ and ‘Inception V3’ are used in the research work. To find the region of interest (ROI) in the image, YOLO (You Only Look Once) architecture is used which also decides the type of model. Edge map images and the spatial images are trained using two separate versions of the MobileNet based transfer learning architecture and then the final joint probabilities are combined to decide upon the hand sign of the image. The experimentation carried out demonstrates that the system provides high accuracy in real time with 100% accuracy.
Examining the Impact of the COVID-19 Pandemic on Ridesourcing Usage: A Case Study of Chicago
Authors: Debnath Anindya , Ogungbire Adedolapo , Mitra Suman 
Published: December 2022

Abstract
The COVID-19 pandemic has led to an unprecedented change in transportation, including shared mobility services. This study examined the effects of the COVID-19 pandemic on ridesourcing usage by leveraging two years (2019 and 2020) of daily ridesourcing trip data in Chicago, Illinois. The study employed a set of Random Effects Panel models to examine the factors contributing to changes in ridesourcing usage before and during the pandemic and how the COVID-19 related policies issued by the state and local agencies affected ridesourcing trips. Results show: i) a considerable drop in total daily trips, total daily trip distances, and total daily trip durations was observed once the stay-at-home order was issued, while an increase in average daily trip distances was evident during the stay-at-home period; ii) the south and west parts of Chicago experienced a relatively larger increase in ridesourcing services during the reopen-I period than the stay-at-home and reopen-II periods; iii) areas with higher employment density produced fewer ridesourcing trips during the pandemic while it was the opposite during the pre-pandemic period; iv) areas with higher median income households, higher employment density, and more rail stations experienced a greater decrease in the change of daily total ridesourcing trips, total trip distances, and total trip durations during the periods of state of emergency and stay-at-home orders. Results of this study provide insights for the policymakers and ridesourcing operators to better respond to an unprecedented crisis like the COVID-19 pandemic and help them to rebuild the ridesourcing ridership in the post-pandemic era.
Outcome of Modified Lateral Intercostal Artery Perforator Flap as a Unique Oncoplastic Technique for Laterally Located Breast Cancer Running title: Modified LICAP as unique oncoplastic procedure for breast cancer
Authors: Hagag Alaa Ahmed Abdelaziz , Hussein Nawel Elsayed , Abdelhamid Mohamed I. , Mahmoud Ramadan , Ashour Hassan R. , Alkilany Mohamed M. 
Published: December 2022

Abstract
Background
Breast cancer is the most common feminine malignant disease. Surgical treatment is the standard care for early stages, and breast conservation therapy became standard management for patients with small-sized tumors. Oncoplastic techniques aim to preserve this precious organ without distortion and with less morbidity. Applying the modified lateral intercostal artery perforator flap offers a one-stage, single position surgery with invisible scar, good access to the axilla and satisfying cosmetics.
Methods
This study was applied to 55 histo-pathologically-confirmed breast cancer patients. All patients were candidates for breast conserving surgery. Observations were recorded and data were collected.
Results
The procedure was overall very good, with smooth recovery after surgery and achieving both oncological safety and pleasant cosmetic results. The early post-operative complication were expected and easily dealt-with. No mortality was recorded. Modified lateral intercostal artery perforator flap offers a chance for patients with laterally located breast cancer and candidates for breast conservation.
Conclusion
In conclusion, our trial with modified LICAP was quiet satisfying. We recommend larger studies and longer periods of follow up.