bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variation in the risk of death due to COVID‐19: An international multicenter cohort study of hospitalized adults
Authors: Quinn Kieran L. , Abdel‐Qadir Husam , Barrett Kali , Bartsch Emily , Beaman Andrea , Biering‐Sørensen Tor , Colacci Michael , Cressman Alex , Detsky Allan , Gosset Alexi , Lassen Mats H. , Kandel Chris , Khaykin Yaariv , Lapointe‐Shaw Lauren , Lovblom Erik , MacFadden Derek R. , Perkins Bruce , Rothman Kenneth J. , Skaarup Kristoffer G. , Stall Nathan , Tang Terence , Yarnell Chris , Zipursky Jonathan , Warkentin Matthew T. , Fralick Mike ,   the COVID‐ACE Group
Published: August 2022

AbstractBackgroundThere is wide variation in mortality among patients hospitalized with COVID‐19. Whether this is related to patient or hospital factors is unknown.ObjectiveTo compare the risk of mortality for patients hospitalized with COVID‐19 and to determine whether the majority of that variation was explained by differences in patient characteristics across sites.Design, Setting, and ParticipantsAn international multicenter cohort study of hospitalized adults with laboratory‐confirmed COVID‐19 enrolled from 10 hospitals in Ontario, Canada and 8 hospitals in Copenhagen, Denmark between January 1, 2020 and November 11, 2020.Main Outcomes and MeasuresInpatient mortality. We used a multivariable multilevel regression model to compare the in‐hospital mortality risk across hospitals and quantify the variation attributable to patient‐level factors.ResultsThere were 1364 adults hospitalized with COVID‐19 in Ontario (n = 1149) and in Denmark (n = 215). In Ontario, the absolute risk of in‐hospital mortality ranged from 12.0% to 39.8% across hospitals. Ninety‐eight percent of the variation in mortality in Ontario was explained by differences in the characteristics of the patients. In Denmark, the absolute risk of inpatients ranged from 13.8% to 20.6%. One hundred percent of the variation in mortality in Denmark was explained by differences in the characteristics of the inpatients.ConclusionThere was wide variation in inpatient COVID‐19 mortality across hospitals, which was largely explained by patient‐level factors, such as age and severity of presenting illness. However, hospital‐level factors that could have affected care, including resource availability and capacity, were not taken into account. These findings highlight potential limitations in comparing crude mortality rates across hospitals for the purposes of reporting on the quality of care.
Virome analysis provides new insights into the association between viruses and Parkinson's disease
Authors: Deng Li , Fu Ping , Ding Ling , Duan Xianlai , Feng Song , Peng Yousong 
Published: August 2022

AbstractParkinson's disease (PD) is a kind of neurodegenerative disease that causes a huge burden to society. Previous studies have suggested the association between PD and multiple viruses. However, there is still a lack of a virome study about PD. This study systematically identified viruses from the public RNA‐sequencing data of more than 700 samples from both PD patients and the control group (most were healthy people). Only nine viruses such as human betaherpesvirus 5 and Merkel cell polyomavirus have been detected in several human brain tissues of the central nervous system, the appendix, and blood of PD patients, and all of these viruses were also detected in the control group. Most viruses were observed to have low abundance in no more than three tissues. No statistically significant differences were observed between the virus abundance in the PD patients and the control group for all viruses. The positive rates of most viruses in PD patients were higher or similar to that in the control group, although those were less than 5% for most viruses. Overall, this is the first study to systematically investigate the virome in PD patients, and provides new insights into the association between viruses and PD.
Multiple gridded‐based precipitation products' performance in Sudan's different topographical features and the influence of the Atlantic Multidecadal Oscillation on rainfall variability in recent decades
Authors: Alriah Mohamed Abdallah Ahmed , Bi Shuoben , Nkunzimana Athanase , Elameen Ayman M. , Sarfo Isaac , Ayugi Brian 
Published: August 2022

AbstractThe selection of a reliable long‐term rainfall dataset is deemed appropriate for hydroclimatic assessments, especially in regions with limited distribution of rain gauge stations like Sudan. The study presents an initial investigation for gridded‐based rainfall products and satellite‐based products over Sudan using standardized statistical methods. Overall, the monthly evaluation revealed reasonable statistical agreement with in situ observations. Seasonal analysis shows that summer rainfall is detected more accurately than yearly rainfall, especially in mountainous areas across the country. Generally, underestimation was observed in all products over most regions on an annual, seasonal, and monthly scale, respectively. Results for the Taylor skill score (TSS) indicated relatively low skills for ECMWF Reanalysis 5th Generation (ERA5), moderate to strong skills for Climate Research Unit (CRU) and Climate Hazards Group Infrared Precipitation with Stations (CHIRPS), against the reference rain gauges among the regions. The regional comparison using TSS when considering monthly and seasonal timescales showed CHIRPS and CRU had the highest performance with an average percentage of 89.6 and 92% in the west (Nyala, Al Geniena, and Al Fasher), 89 and 84.6% at the central part (Khartoum, Wad Madani, and Al Obied), and 92.5 and 86.5% in the south (Al Damazine and Kadogli). At 95% confidence level, a significant increasing trend was observed over the highlands at the centre (Al Obied) and western areas (Al Geniena and Nyala), while most stations showed positive trends. Further analysis on temporal correlation with Atlantic Multidecadal Oscillation (AMO) demonstrated a strong correlation between the AMO PC1 and JJAS rainfall PC1 (82%). The west recorded the highest response to AMO (90%), while the east had the lowest response (74%), with the north, central, and south obtaining 77, 76, and 76%, respectively. Our findings provide useful information about rainfall in Sudan, suggesting CHIRPS data for monitoring rainfall variability and extreme events which should encourage its use in areas with scarce stations.
Multiyear La Niña effects on the precipitation in South America
Authors: Lopes Aixa Braga , Andreoli Rita V. , Souza Rodrigo A. F. , Cerón Wilmar L. , Kayano Mary T. , Canchala Teresita , de Moraes Djanir Sales 
Published: August 2022

AbstractThe effect of multiyear La Niña (LN) events on precipitation in South America (SA) was assessed considering 10 persistent LN events over two successive years, referred to as Y1 and Y2 for the 1901–2012 period. Y1 spans from the austral winter of the first year to autumn of the second year, and Y2 spans from the austral winter of the second year to autumn of the third year. Comparisons were performed season by season of the Y1 and Y2. Composites revealed that the teleconnections related to a multiyear LN event during its Y1 and Y2 years, responsible for distinct seasonal precipitation anomaly patterns in SA, were associated with different tropical ocean conditions. In spring, the negative sea surface temperature (SST) dipole in the Indian Ocean during the Y2 was not observed during Y1. Different LN‐related SST anomaly patterns in the tropical Atlantic between Y1 and Y2 occurred in the other seasons. Over northern/northeastern SA, the positive precipitation anomalies became weaker (stronger) during austral summer and autumn (winter and spring) of the Y2 than Y1 and were associated with changes in the Walker cells. During austral spring and summer, southeastern presented drier conditions during the Y2 than Y1. In the spring of Y2, two Rossby wave trains, one associated with the LN‐related anomalous cooling in the equatorial Pacific and another triggered by the upper‐level anticyclone in the tropical Indian Ocean, characterized the circulation pattern over SA which explains the difference in precipitation anomalies between the Y2 and Y1. These drier (wetter) conditions during austral spring and summer (winter and spring), particularly over southern and southeastern Brazil (Colombia) in the Y2, might have more severe effects on the regional hydrological cycle than those in the Y1. The results here indicate that accurate prediction of LN duration is crucial in a climate‐monitoring context.
Digital Gait Biomarkers Allow to Capture 1‐Year Longitudinal Change in Spinocerebellar Ataxia Type 3
Authors: Ilg Winfried , Müller Björn , Faber Jennifer , van Gaalen Judith , Hengel Holger , Vogt Ina R. , Hennes Guido , van de Warrenburg Bart , Klockgether Thomas , Schöls Ludger , Synofzik Matthis ,   the ESMI Consortium
Published: August 2022

ABSTRACTMeasures of step variability and body sway during gait have shown to correlate with clinical ataxia severity in several cross‐sectional studies. However, to serve as a valid progression biomarker, these gait measures have to prove their sensitivity to robustly capture longitudinal change, ideally within short time frames (eg, 1 year). We present the first multicenter longitudinal gait analysis study in spinocerebellar ataxias. We performed a combined cross‐sectional (n = 28) and longitudinal (1‐year interval, n = 17) analysis in Spinocerebellar Ataxia type 3 subjects (including seven preataxic mutation carriers). Longitudinal analysis showed significant change in gait measures between baseline and 1‐year follow‐up, with high effect sizes (stride length variability: P = 0.01, effect size rprb = 0.66; lateral sway: P = 0.007, rprb = 0.73). Sample size estimation for lateral sway indicates a required cohort size of n = 43 for detecting a 50% reduction of natural progression, compared with n = 240 for the clinical ataxia score Scale for the Assessment and Rating of Ataxia (SARA). These measures thus present promising motor biomarkers for upcoming interventional studies. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
Transaktionen: Die doppelte Zeitenwende
Authors: Schneider Bernd , Holz Lukas Immanuel 
Published: August 2022

AbstractWährend die chemische Industrie auf dem grünen Transitionspfad beschleunigen muss, sieht sie sich nun zudem durch geopolitische Probleme wie die Invasion der Ukraine durch Russland herausgefordert.
Chemie in Europa
Authors: Zbikowski Frauke 
Published: August 2022

AbstractDer europäische Publikationsverbund Chemistry Europe zeichnet jedes Jahr engagierte Autoren, Gasteditoren und Gutachter als Fellows aus. Wir haben die Fellows Sonja Herres‐Pawlis, Lutz Ackermann und Nuno Maulide gefragt, wie sie die Chemie in Europa einschätzen.
The resource constrained clustered shortest path tree problem: Mathematical formulation and Branch&Price solution algorithm
Authors: Ferone Daniele , Festa Paola , Fugaro Serena , Pastore Tommaso 
Published: August 2022

AbstractIn this article, the Resource Constrained Clustered Shortest Path Tree Problem is defined. It generalizes the classic Resource Constrained Shortest Path Tree Problem since it is defined on an undirected, complete and weighted graph whose set of nodes is partitioned into clusters. The aim is then to find a shortest path tree respecting some resource consumption constraints and inducing a connected subgraph within each cluster. The main support and motivation for studying this problem are related, among the others, to the design of telecommunication networks, and to Disaster Operations Management. In this work, we present a path‐based formulation for the problem, addressing the case of local resource constraints, that is, resource constraints on single paths. For its resolution, a Branch&Price algorithm featuring a Column Generation approach with Multiple Pricing Scheme is devised. A comprehensive computational study is conducted, comparing the proposed method with the results achieved by the CPLEX solver, adopted to solve the mathematical model. The numerical results underline that the Branch&Price algorithm outperforms CPLEX, both in terms of solution cost and time.
Impact damage assessment in patch‐repaired carbon fiber‐reinforced polymer laminates using the nonlinear Lamb wave‐mixing technique
Authors: Yin Zhenhua , Tie Ying , Duan Yuechen , Li Cheng , Chen Dong 
Published: August 2022

AbstractThis study investigates assessment of the barely visible impact damage (BVID) caused by low‐velocity impact (LVI) in single‐sided patch‐repaired orthotropic carbon fiber‐reinforced polymer (CFRP) laminates using experimental and numerical nonlinear Lamb wave‐mixing techniques. An accurate finite element method (FEM) approach consisting of three analysis steps of LVI, vibration damping, and nonlinear ultrasonic mixing detection is proposed to predict the relationship between LVI damage and nonlinear Lamb wave‐mixing propagation. The LVI step in the FEM simulation is verified by drop‐weight impact tests, and the nonlinear Lamb wave‐mixing detection step in FEM is verified by comparing with the RITEC RAM‐5000 SNAP nonlinear mixing detection system. The BVID of patch‐repaired specimens is assessed with mixing relative acoustic nonlinearity parameters (MRANPs). CFRP laminates repaired with various external patch parameters of different sizes, numbers of layers and stacking sequences are evaluated by the FEM approach. Finally, an optimized patch design in which the MRANPs are the smallest is determined. Therefore, the CFRP laminate containing a hole is recommended to be repaired with a circular three‐layer patch with a radius of 2.5 r and a stacking sequence of [90/90/90].
Demystifying the role of graphene nanoplatelets percentage and sonication duration on the mechanical properties of the glass fabric/graphene nanoplatelets hybrid nano‐composite
Authors: Mamallan Santhanakrishnan , Narayanan Venkateshwaran 
Published: August 2022

AbstractIn this study, the effect of sonication time on the mechanical properties of graphene nanoplatelets (GnPs) glass fiber composites were discussed. The Sonication process is one of the best techniques to ensure uniform dispersion of nanofillers into the polymer matrix; otherwise, they form agglomerates of multilayers. To fulfill the massive demand for mass production, ultrasonic bath‐type sonication were deployed. In this study, 0, 1, 2, 3, 4, and 5 wt% of GnPs were added with epoxy at different sonication durations, precisely 0, 20, 40, and 60 min. Other sonication process parameters were kept constant with a sonication frequency of 28 KHz. Bidirectional glass fabric materials was used as reinforcement material in the fabrication of the laminates. In total, 21 laminates were fabricated using the hand lay‐up technique in various amalgamations. The tensile and flexural specimens were cut from the laminates as per the standards to determine their mechanical properties. The scanning electron microscope (SEM) images were used for the structural analysis of the glass fiber reinforced GnPs/epoxy composite. Surface morphology of GnPs becomes more wrinkled, resulting in a stronger graphene/epoxy matrix interface, enhancing the tensile strength and tensile modulus performance of the nano‐composites increases up to 37.12% and 66.30%, the flexural strength and flexural modulus performance of the nano‐composites increases up to 55.74% and 91.23% respectively. Based on the investigations, the influence of the GnPs percentage and the sonication duration for the preparation of the nano‐composites with the help of technique for order of preference by similarity to ideal solution (TOPSIS) optimization technique.
Lake Sturgeon Movement after Trap and Transfer around Two Dams on the Menominee River, Wisconsin–Michigan
Authors: Isermann Daniel A. , Raabe Joshua K. , Easterly Emma G. , Schulze Joshua C. , Porter Nicholas J. , Dembkowski Daniel J. , Donofrio Michael C. , Kramer Darren R. , Elliott Robert F. 
Published: August 2022

AbstractFish behavior after passage or transfer around dams is a critical component in determining whether the goals of these efforts are achieved, but these behaviors are often poorly understood. An elevator was constructed in the lowermost hydroelectric dam on the Menominee River, Wisconsin–Michigan; it is the first elevator specifically designed to capture Lake Sturgeon Acipenser fulvescens for upstream transfer above two dams, providing access to high‐quality spawning and early life habitat. Our objectives were to determine whether (1) Lake Sturgeon transferred upstream remained upstream for at least one spawning opportunity; (2) spawning opportunity, time to reach the next dam upstream, and residency in different segments of the river were related to sex, capture method (elevator versus electrofishing), and season of transfer; and (3) the probability of fish transitioning back downstream of the two dams varied among months. We evaluated posttransfer behaviors of 139 Lake Sturgeon that were captured in the elevator or by electrofishing, implanted with acoustic transmitters, transferred upstream (in spring or fall) from fall 2014 to spring 2017, and monitored until fall 2018 using 20–23 stationary acoustic receivers deployed throughout the river. Most Lake Sturgeon (91%) remained upstream for at least one spawning opportunity. The probability of remaining for one spawning opportunity was not related to sex, fish capture method, or season of transfer. Residency times within the two impoundments and time to reach the next dam upstream varied among individual fish. A multistate model indicated that monthly survival after upstream transfer was high and that Lake Sturgeon typically remained above both dams in late fall to early spring, with most downstream movements occurring in April and May. Our results indicate that Lake Sturgeon transferred upstream have the potential to contribute offspring that may help to bolster the Lake Sturgeon population in Lake Michigan, but additional research may help in determining whether these contributions occur.Impact StatementLake Sturgeon that were transferred upstream of two dams remained upstream of the dams for at least one spawning opportunity, representing the first step in determining whether transfers can be used to increase Lake Sturgeon abundance in the Great Lakes and beyond.
Expression and distribution patterns of VEGF, TGF‐β1 and HIF‐1α in the ovarian follicles of Tibetan sheep
Authors: Guo Yajun , Liu Miaomiao , Mfoundou Jos Dorian Lawson , Wang Xinrong 
Published: August 2022

AbstractBackgroundHypoxia‐inducible factor‐1α (HIF‐1α), vascular endothelial growth factor (VEGF) and transforming growth factor β1 (TGF‐β1) are multifunctional growth factors that play an important role in follicular growth and development. However, its biological function in the follicular development of Tibetan sheep at different stages has not been described.ObjectivesThe purpose of this study was to investigate the effect of VEGF, TGF‐β1 and HIF‐1α expression and distribution on the development of follicles of different sizes.MethodsImmunohistochemistry (IHC), western blot (WB) and quantification real‐time polymerase chain reaction (qRT‐PCR) were used to detect the localisation and quantitative expression of VEGF, TGF‐β1 and HIF‐1α proteins and mRNA in small‐ (< 3 mm), medium‐ (3 mm < diameter < 5 mm)‐, and large‐ (> 5 mm) sized follicles.ResultsThe results showed that the proteins VEGF, TGF‐β1 and HIF‐1α, as well as their mRNA, were expressed in follicles. However, the expression in medium‐sized follicles was significantly higher than that in large‐ and small‐sized follicles (p <0.05). IHC also showed that the proteins VEGF, TGF‐β1, and HIF‐1α were distributed in granulosa cells (GCs) in small‐, medium‐, and large‐sized follicles.ConclusionsThis study indicates that VEGF, TGF‐β1 and HIF‐1α, which operate in an autocrine or paracrine manner with the GCs, influence the follicular progressive growth, suggesting that these growth factors are closely associated with the follicular growth and development in ovarian.
Fears and Hopes
Authors: Garrido-Cumbrera Marco , Navarro-Compán Victoria , Bundy Christine , Mahapatra Raj , Makri Souzi ,   Universidad de Sevilla, Plazuelo-Ramos Pedro , Poddubnyy Denis 
Published: August 2022

AbstractPatients with axSpA are likely to live with a range of hopes, such as retaining a good quality of life and normal social and physical functioning, and fears, including a fear of suffering, losing autonomy, and being a burden on relatives, relating to their disease (Garrido-Cumbrera et al. Rheumatol Ther. 2017:219–231, 2017; Gossec et al. Value Health. 18:A715, 2015).
Objectives
Authors: Garrido-Cumbrera Marco , Navarro-Compán Victoria , Bundy Christine , Mahapatra Raj , Makri Souzi ,   Universidad de Sevilla, Plazuelo-Ramos Pedro , Poddubnyy Denis 
Published: August 2022

AbstractThe overarching aim of the IMAS European project was to expand the knowledge of axSpA in Europe by gathering the perspectives of patients diagnosed with the disease.
Methodology
Authors: Garrido-Cumbrera Marco , Navarro-Compán Victoria , Bundy Christine , Mahapatra Raj , Makri Souzi ,   Universidad de Sevilla, Plazuelo-Ramos Pedro , Poddubnyy Denis 
Published: August 2022

AbstractThis cross-sectional market research survey was adapted from the Spanish Atlas of Axial Spondyloarthritis 2017, a pilot survey conducted from January to March 2016 (Garrido-Cumbrera et al. Reumatol Clin. 15:127–132, 2019a).
Demographic Profile of Survey Respondents
Authors: Garrido-Cumbrera Marco , Navarro-Compán Victoria , Bundy Christine , Mahapatra Raj , Makri Souzi ,   Universidad de Sevilla, Plazuelo-Ramos Pedro , Poddubnyy Denis 
Published: August 2022

AbstractThe IMAS European survey was conducted across 13 European countries and included a wide range of patients with axSpA from varying sociodemographic backgrounds.
Contested Urban Green Spaces and Environmental Justice in Northern Europe
Authors: Plüschke-Altof Bianka , Sooväli-Sepping Helen 
Published: August 2022

AbstractThe chapter provides an overview of the objectives, structure, content and results of this joint volume. Starting from the paradox of well-known green space benefits on the one hand and multiple challenges to their fair provision on the other hand, the book argues to put green space contestations and environmental justice concerns into focus when striving for a sustainable city development. As the edited volume unites interdisciplinary and multi-method studies on green space use and planning, it enriches environmental justice studies by widening the understanding of green space access, critically evaluating cases of procedural injustice and providing in-depth studies on the contexts of injustices in urban greening. Based on the results of these studies, a future research agenda is proposed in this introductory chapter.