bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Survey of Bone Grafting Practice Patterns in North American Cleft Surgeons
Authors: Qamar Fatima , Cray James J. , Halsey Jordan , Rottgers S. Alex 
Published: October 2022

Introduction Alveolar bone grafting aims to restore bony continuity of the alveolus and provide optimal periodontal support for teeth adjacent to the cleft. We created a survey of cleft surgeons to assess the current standard of care regarding this procedure. Methods A multiple choice survey was implemented using Qualtrics software and emailed to a list of 708 surgeons from the ACPA membership directory. Correlation between various provider factors and treatment practices was assessed with Fisher's exact test and likelihood ratio tests. Results The response rate was 17.5%. Eighty-seven percent of providers preferred to perform grafts prior to secondary canine eruption while 10% favored before central incisor eruption. Eighty-one percent favored palatal expansion prior to bone grafting. Wide variability existed regarding the time to initiate postoperative orthodontics; 43% waited 4 to 6 months. Sixty-four percent of surgeons now utilize cone beam CT to assess graft take. The majority of respondents utilized cancellous bone autograft (92%) from the anterior iliac crest (97%) as graft material. Seventy percent used three or more modalities for post-operative pain control management. Early career surgeons (0–5 years) appeared more likely to use non-autologous materials ( p < .01) for grafting. Conclusion Alveolar bone grafting prior to secondary canine eruption remains the most common strategy but other protocols are employed. Surgeons utilize multiple modalities for radiographic evaluation and most often use autologous cancellous bone as the primary grafting material. There is no true consensus on the perioperative timing and sequencing of orthodontic manipulation while principles of multimodal perioperative pain control appear widely accepted.
Risk Factors for Prolonged Opioid Use Following Total Hip Arthroplasty and Total Knee Arthroplasty: A Narrative Review of Recent Literature
Authors: VanIderstine Carter , Johnston Emily 
Published: October 2022

Objective: To provide pharmacists and other health care professionals with the knowledge required to minimize the risk of prolonged opioid use following total hip arthroplasty (THA) and total knee arthroplasty (TKA). Data Sources: A literature search of PubMed and Embase was performed, and included the search terms: (opioid OR opiate OR opium) AND (risk factor OR predict*) AND (arthroplasty OR replacement) NOT shoulder. Study Selection and Data Extraction: Randomized control trials, cohort studies (both prospective and retrospective), systematic reviews, and meta-analyses were included if risk ratios (RRs) or odds ratios (ORs) were reported and published within the last 5 years. Data Synthesis: ]Twenty studies met inclusion criteria, including 2 meta-analyses and 2 prospective studies. There were several risk factors that overlapped between studies and presented clinically significant risks for prolonged opioid use following THA and TKA surgery. Of these, age < 65 (RRs: 1.15-9.36), preoperative opioid use (RRs: 1.09-7.81), larger quantities of opioids prescribed at discharge (RRs: 1.26-8.81), and TKA surgery (RRs: 1.73-6.07) were the most significant. Several risk factors were recently described, including migraines (RRs: 1.14-5.11) and fibromyalgia (RRs: 1.1-2.3) that may be of interest for further research. Relevance to Patient Care and Clinical Practice: This review presents a discussion of the factors associated with prolonged opioid use following THA and TKA surgeries, which are among the most common orthopedic surgeries. Conclusions: Prescribers should carefully consider patient-specific factors when prescribing opioids as there are several factors, including age, surgery type, and medical conditions that can predispose patients to prolonged opioid use.
PIK3CA Mutational Analysis in Patients With Macrodactyly
Authors: Becker Jakob , Gross Ulrike Camenisch , Weber Daniel M , Weibel Lisa , Theiler Martin , Brandt Simone , Bode Peter K 
Published: October 2022

Background Somatic mosaicism for PIK3CA mutations causes various types of growth disorders, which have been summarized under the term PROS ( PIK3CA related overgrowth spectrum). Targeted therapy with PI3K inhibitors seems to be a promising alternative for severe PROS cases. Therefore, PIK3CA testing may become more relevant in the future. Methods We report on 14 PROS patients, who had surgery for macrodactyly in the majority of cases. Clinical data were retrieved from the patient’s records. Macroscopic and microscopic findings were retrospectively reviewed. Mutational analysis was performed on formalin-fixed paraffin-embedded (FFPE) material. Results Patient age ranged from 7 months to 35 years. Five patients showed additional anomalies. One patient had CLOVES syndrome. The majority of the specimens were ray resections characterized by hypertrophic fat tissue. Overall, microscopy was subtle. The abnormal adipose tissue showed lobules exhibiting at least focally fibrous septa. In each case, we could detect a PIK3CA mutation. Conclusion Histology of affected fat tissue in PROS patients is overall nonspecific. Therefore, mutational analysis represents the key to the diagnosis, especially in unclear clinical cases. We demonstrated that FFPE material is suitable for PIK3CA testing, which can be considered as basis for targeted therapy with PI3K inhibitors.
Structural priming and cross-linguistic influence in L2 comprehension of Dutch relative clauses and PP-attachments: Differences between German and English learners of Dutch
Authors: Bosma Evelyn , Ayçiçek Seda , Mikawa Momo , Muller Melissa , Visser Ella , Kootstra Gerrit Jan 
Published: October 2022

Aims and Objectives/Purpose/Research Questions: This study investigated cross-linguistic influence and structural priming in L2 learners’ comprehension of Dutch relative clauses (RCs) and PP-attachments. While PP-attachments are structurally ambiguous in all three languages, RCs are structurally ambiguous in Dutch and German, but not in English. Design/Methodology/Approach: L1 speakers of German ( n = 18) and English ( n = 19) completed a structural priming task in their L2 Dutch with a pre-test, a priming phase, an immediate post-test, and a delayed post-test 1 day later. Data and Analysis: The data were analysed using t tests and repeated-measures analysis of variance (ANOVA). In the pre-test, L1 speakers of German showed a clear parsing preference for subject RCs and a slight preference for VP-attachment, whereas L1 speakers of English showed a clear parsing preference for object RCs and a slight preference for NP-attachment. The English L1 speakers were sensitive to structural priming, but only when primed with subject RCs and VP-attachments. This priming was still visible 1 day later. The German L1 speakers were not sensitive to the priming manipulation. Findings/Conclusion: The pre-test showed that L1 parsing preferences influence L2 processing; the structural priming effects in the English L1 speakers showed an inverse frequency effect that is based on experiences from both L1 and L2; the delayed post-test showed that structural priming can be seen as a form of implicit learning. Originality: This is the first structural priming study that compared two groups of L2 speakers on two different structures. Significance/Implications: Structural priming can be seen as a form of implicit learning in which experienced frequencies from both L1 and L2 give rise to a developing shared syntax.
Public interest in Invisalign in developed and developing countries: A Google Trends analysis
Authors: Livas Christos , Delli Konstantina , Lee Shin-Jae , Pandis Nikolaos 
Published: October 2022

Objective: To investigate long-term changes and possible seasonal variations in Google search volumes related to Invisalign in developed and developing countries. Design: Cross-sectional, Google search-based study. Methods: Google Trends (GT) was accessed to retrieve the Relative Search Volume (RSV) of Google queries related to the search term ‘Invisalign’ in 10 countries selected on the basis of population size, Internet usage and socioeconomic criteria between 1 January 2004 and 30 June 2021. The countries examined were the following: Australia, Brazil, Italy, Mexico, Philippines, Saudi Arabia, Spain, Thailand, UK and USA. By applying the time series decomposition method, the trend component and the seasonal variation were identified. Results: Overall, RSVs regarding Invisalign have increased significantly in all countries with the developed countries outperforming developing countries throughout most of the observation period. There was no meaningful pattern when the trends were compared either on a monthly or quarterly basis. Similar peaks and valleys were found in Australia - Brazil, UK - USA, Italy - Spain and Saudi Arabia - Philippines - Thailand. Conclusions: Public interest in online information for Invisalign has grown significantly over the years across countries of diverse socioeconomic and cultural backgrounds while seasonal patterns were observed in the related Google searches. Seasonal fluctuations seemed to follow the academic calendar. The study results may have direct implications on practice management and professional development.
Global prevalence estimates of poststroke fatigue: A systematic review and meta-analysis
Authors: Zhan Jie , Zhang Peiming , Wen Hao , Wang Yiqiao , Yan Xiaoting , Zhan Lechang , Chen Hongxia , Xu Nenggui , Lu Liming 
Published: October 2022

Background and purpose: Poststroke fatigue (PSF) is a common complication after stroke. However, information on the global prevalence of PSF and how this varies geographically and by population is lacking. Our aim was to examine the global prevalence of PSF and identify sources of heterogeneity in the published literature. Methods: Four medical databases (PubMed, EMBASE, PsycINFO, and Cochrane Database of Systematic Reviews) were searched from their inception to 28 February 2022. The Joanna Briggs Institute Critical Appraisal Instrument for studies reporting prevalence data (JBI) was used to assess the risk of bias (ROB) of the included studies. The primary outcome was the prevalence of PSF determined using a random-effects model. Subgroup analysis and meta-regression models were used to define the source of heterogeneity. Results: In all, 66 studies with 11,697 patients were included in this meta-analysis. The overall quality of the included studies was medium. The global pooled prevalence of PSF in stroke survivors was 46.79% (95% confidence interval (CI), 43.41–50.18%). The prevalence estimates of PSF based on the Fatigue Severity Scale (FSS), Multidimensional Fatigue Inventory-20 (MFI-20), and Fatigue Assessment Scale (FAS) were 47.44% (95% CI, 43.20–51.67%), 51.69% (95% CI, 44.54–58.83%), and 36.13% (95% CI, 23.07–49.18%), respectively. Prevalence rates of PSF were higher in females (53.19%; 95% CI, 46.46–59.92%), in hemorrhagic stroke (57.54%; 95% CI, 40.55–74.53%), in those with a college degree or higher (53.18%; 95% CI, 42.82–63.54%), and in those with unmarried or divorced status (59.78%; 95% CI, 44.72–74.83%). Conclusions: The prevalence of PSF in stroke survivors is high, affecting almost half of all stroke sufferers. PSF rates were higher with female gender, being unmarried or divorced, having a higher educational level, and being hemorrhagic compared to ischemic stroke. Trial registration: PROSPERO (CRD42021269441).
Delphi panel for consensus on the optimal management of dabrafenib plus trametinib-related pyrexia in patients with melanoma
Authors: Frazer Ricky , Gupta Avinash , Herbert Christopher , Payne Miranda , Diaz-Mendoza Sergio , Vincent Sally-Anne , Kovaleva Elena 
Published: October 2022

Purpose: Dabrafenib and trametinib combination therapy (dab + tram) is indicated to treat BRAF V600 mutation–positive unresectable/metastatic melanoma and as adjuvant treatment for resected stage III disease. Dab + tram–related pyrexia may require early therapy discontinuation. A modified Delphi panel was conducted to develop consensus on the optimal management of dab + tram–related pyrexia in patients with melanoma. Methods: In all, 10 UK oncologists experienced in melanoma management participated in a three-round modified Delphi study (Round 1: one-to-one interview; Rounds 2 and 3: email survey). In each round, participants rated the extent of their agreement with statements about defining and managing dab + tram–related pyrexia. Consensus was defined as >80% agreement for critical management (CM) and >60% for non-critical management (NCM) statements. Results: All 10 participants completed Round 1; 9 completed Rounds 2 and 3. Consensus was reached on 42/66 statements (20 CM and 22 NCM). Drug-related pyrexia was agreed as being strictly an elevation of body temperature, although other symptoms may be present (89% agreement). Panelists agreed on the need for simple and generic guidance on dab + tram–related pyrexia management that does not differentiate between patient groups (100%), and that management of first and second dab + tram–related pyrexia episodes should be the same regardless of treatment intent (100%). Regarding CM, participants agreed that both dab and tram should be interrupted for pyrexia (100%) without considering the use of steroids (89%); patients on dab + tram presenting to non-oncology services with pyrexia should be directed to an oncology-specific service as soon as possible and assessed for infection (100%). NCM statements on steroid use following dab + tram interruption and when to restart dab + tram did not reach consensus. Conclusions: These consensus statements provide a framework on optimal management of dab + tram–related pyrexia in patients with melanoma which should inform future guidelines.
Systematic Review of Surgical Interventions for Inferior Turbinate Hypertrophy
Authors: Zhang Kathy , Pipaliya Royal M. , Miglani Amar , Nguyen Shaun A. , Schlosser Rodney J. 
Published: October 2022

BackgroundVarious surgical interventions exist for treatment of inferior turbinate hypertrophy (ITH). Though mucosal-sparing techniques are generally preferred, there is lack of consensus on the optimal technique.ObjectiveThis systematic review sought to evaluate the evidence for treatment of bilateral nasal obstruction via inferior turbinate reduction (ITR) and provide a meta-analysis of expected results of various techniques.MethodsPubMed, Scopus, Cochrane Library databases were queried to include articles describing surgical treatment for ITH. Exclusion criteria were concurrent nasal procedures or non-mucosal ITH. Primary outcomes included visual analog scale for nasal obstruction, nasal cavity volume by acoustic rhinometry, and resistance by anterior rhinomanometry. Subgroup analyses assessed outcomes by rhinitis diagnosis and length of follow-up, and radiofrequency ablation (RFA) was compared to microdebrider-assisted turbinoplasty (MAIT).ResultsA total of 1870 studies were identified with 62 meeting inclusion criteria. Reported techniques included turbinectomy, submucosal resection, RFA, MAIT, laser, or electrocautery. All techniques demonstrated significant improvements in nasal obstruction using the visual analog scale. Further comprehensive physiologic data for RFA, MAIT, and laser was available and, compared to baseline, these techniques resulted in significant improvements in nasal resistance, nasal cavity volume, and nasal airflow. Six studies directly compared RFA and MAIT with statistically similar results on VAS, nasal cavity volume, and resistance with median follow-up time of 3.5 months. Assessment of VAS congestion over time reveals peak benefit is achieved between 3–6 months follow-up.ConclusionsAll reviewed ITR techniques improve patient-reported nasal obstruction. RFA and MAIT provide comparable improvements in patient-reported and physiologic nasal airflow outcomes and while benefits are sustained long-term, the peak benefit for both techniques appears to be achieved within the first year.
Virtual and augmented reality applications to improve older adults’ quality of life: A systematic mapping review and future directions
Authors: Baragash Reem Sulaiman , Aldowah Hanan , Ghazal Samar 
Published: October 2022

Objective The use of virtual reality and augmented reality to improve older adults’ quality of life has rapidly increased in recent years. This systematic mapping review aimed to provide a comprehensive overview of existing research that identifies and classifies current virtual reality and augmented reality applications that enhance the quality of life of older adults to increase the understanding of the impact of these technologies. Methods To reach this objective, a systematic mapping review was conducted of the studies published between 2009 and 2020 in major scientific databases, such as IEEE Xplore, Web of Science, Scopus, and PubMed. A total of 57 studies were analyzed and classified into four main quality of life domains: physical, cognitive, psychological, and social well-being. Results The findings showed that virtual reality and augmented reality have found their places in many quality of life studies of older adults. Although virtual reality and augmented reality applications are notably growing in the physical and cognitive well-being domains in training and rehabilitation settings, they are still in the early stages of development in psychological and social well-being research as well as healthcare settings. Our findings also revealed that virtual reality games, particularly motion-based exergames, and 3D augmented reality systems are the most common virtual reality and augmented reality types among the reviewed studies. Moreover, balance and attention were the most prevalent physical and cognitive functions when using motion-based and immersive virtual reality exergames and augmented reality systems and games, respectively, while confidence and interaction were the most dominant psychological and social functions. Conclusion This mapping review provides a comprehensive overview of potential areas for further research in this field, thereby assisting researchers, technologists, and health practitioners in expanding this field of research.
Movement Variability and Loading Characteristics in Athletes With Athletic Groin Pain: Changes After Successful Return to Play and Compared With Uninjured Athletes
Authors: Baida Samuel , King Enda , Gore Shane , Richter Chris , Franklyn-Miller Andrew , Moran Kieran 
Published: October 2022

Background: Athletic groin pain (AGP) can lead to altered movement patterns during rapid deceleration and acceleration. However, the effect of AGP on movement variability and loading patterns during such actions remains less clear. Purpose: To investigate, using a continuous lateral hurdle hop task, how movement variability and magnitude measures of 3-dimensional (3D) kinematic, kinetic, and vertical ground-reaction force (vGRF) variables are (1) affected by AGP (AGP vs uninjured controls [CON]) and (2) changed after successful rehabilitation (AGP prerehabilitation vs AGP postrehabilitation vs CON). Study Design: Controlled laboratory study. Methods: A total of 36 athletes diagnosed with AGP and 36 uninjured CON athletes matched on age (18-35 years), level (subelite), and type of sports played (multidirectional field sport) performed a continuous lateral hurdle hop test that involved 10 side-to-side hops over a 15-cm hurdle. The 3D joint kinematic, kinetic, and vGRF variables (total, eccentric, and concentric; ground contact time, peak force, and impulse; and eccentric rate of force development) were examined. The AGP and CON groups were tested at baseline, and the AGP group was retested after participants successfully completed a standardized, exercise-based rehabilitation program targeting intersegmental control. Results: There were no differences in baseline characteristics between the AGP (mean ± SD: age, 27.5 ± 4.8 years; height, 179.8 ± 6.3 cm; mass, 80.3 ± 7.1 kg) and CON (mean ± SD: age, 24.1 ± 4.5 years; height, 181.0 ± 5.8 cm; mass, 80.4 ± 8.2 kg) groups. At baseline, athletes with AGP demonstrated altered loading patterns in the vGRF (longer ground contact times, reduced peak force, and reduced rate of force development) compared with CON athletes, while no significant difference in any movement variability variables was evident. After rehabilitation, the athletes with AGP demonstrated significant changes in transverse and coronal plane hip and trunk kinematics, with no significant differences in vGRF variables compared with the CON group. Conclusion: The differences in baseline vGRF measures between the AGP and CON groups were no longer evident after athletes with AGP underwent rehabilitation. No differences in movement variability were evident between the AGP and CON groups, either before or after rehabilitation. Clinical Relevance: Rehabilitation programs should consider targeting intersegmental hip and trunk movement patterns to positively influence loading patterns in athletes with AGP.
Trends in Anterior Cruciate Ligament Repair: A Bibliometric and Visualized Analysis
Authors: Li Jinfei , Rothrauff Benjamin , Chen Shuyi , Zhao Shuying , Wu Zhaoxi , Chen Qi , He Jinshen 
Published: October 2022

Background: Bibliometrics is a methodology that measures the scientific output of an author, institution, or country. Visualized analysis is the transformation of data into visible form by software, highlighting important features, including commonalities and anomalies, allowing users to easily and quickly perceive significant aspects of their data. Purpose: To conduct a bibliometric analysis of the literature on anterior cruciate ligament (ACL) repair, with visualization of trends, in order to identify the areas of interest and the primary researchers involved in ACL repair. Study Design: Cross-sectional study. Methods: The PubMed database was queried on April 14, 2022, for publications that reported on ACL repair from 1960 onward. The initial search resulted in 1392 publications. Filter settings were applied to remove publications with weak correlation, such as those on meniscal repair and ACL reconstruction. Publication information, citations, authors, commonly used terms, and affiliated institutions and countries were analyzed by VOSviewer and Python. Results: A total of 553 articles were included for analysis. Three techniques were visualized: bridge-enhanced ACL repair, internal brace, and dynamic intraligamentary stabilization. The most published authors were Martha Murray (51 articles), Gregory Difelice (35 articles), and Braden Fleming (31 articles). The most cited article was “Collagen–Platelet Rich Plasma Hydrogel Enhances Primary Repair of the Porcine Anterior Cruciate Ligament” by Murray et al. The journals with the most publications on ACL repair were the American Journal of Sports Medicine (n = 49); Knee Surgery, Sports Traumatology, Arthroscopy (n = 49); and Arthroscopy (n = 48). The top 3 institutions by publication number were the Hospital for Special Surgery (n = 51), Boston Children’s Hospital (n = 49), and Brown University (n = 31), with the most publications coming from the United States (n = 242), Germany (n = 83), and the United Kingdom (n = 47). Conclusion: The results demonstrate that the research on ACL repair comes from a small number of authors and corresponding institutions; the top sports medicine journals and the developed countries have an interest in this topic.