bluuebunny/crossref_metadata_2025_split huggingface dataset:
MENGGAGAS FORMULASI BADAN REGULASI NASIONAL SEBAGAI SOLUSI REFORMASI REGULASI DI INDONESIA
Authors: Winata Muhammad Reza , Musais Ibnu Hakam 
Published: October 2022

<p><span lang="EN-US">Pembentukan Badan Regulasi Nasional (BRN) atau sebelumnya disebut Pusat Legislasi Nasional (PLN) merupakan gagasan yang disampaikan Presiden Joko Widodo sebagai upaya mengatasi problematika peraturan perundang-undangan. Meskipun, Pemerintah telah mengesahkan </span><span lang="EN-US">UU No. 15 Tahun 2019 tentang Pembentukan Peraturan Perundang-undangan yang mengatur beberapa kewenangan BRN/PLN. Namun, ternyata sampai saat ini BRN/PLN ini belum juga terbentuk, bahkan terjadi stagnansi perkembangan. Permasalahan yang hendak dijawab: Bagaimana problematika dan praktik penyusunan peraturan perundang-undangan saat ini? Bagaimana formulasi Badan Regulasi Nasional yang ideal kedepan mewujudkan reformasi regulasi? Metode penelitian menggunakan metode yuridis normatif dengan pendekatan peraturan dan konseptual. Hasil penelitian menunjukan agenda reformasi regulasi di Indonesia masih menghadapi berbagai kendala: hiper regulasi, kontradiksi substansi, disharmonisasi kelembagaan negara, serta inkonsistensi proses bisnis. Formulasi ideal BRN/PLN berdasarkan konsep kelembagaan negara yaitu BRN/PLN merupakan Lembaga Pemerintah Non Kementerian (LPNK) yang diatur melalui Peraturan Presiden. BRN/PLN berwenang: a. Mewakili Pemerintah dalam pembentukan undang-undang; b. Harmonisasi Peraturan Perundang-undangan; c. Monitoring dan Evaluasi Pelaksanaan Peraturan Perundang-undangan. Sedangkan, struktur kelembagaan BRN/PLN: a. Berada di bawah Presiden; b. Pimpinan ditunjuk dan bertanggung jawab kepada Presiden. Direktorat Jenderal Peraturan Perundang-Undangan dan Badan Pembinaan Hukum Nasional Kementerian Hukum dan Hak Asasi Manusia, serta fungsi harmonisasi peraturan perundang-undangan pada Sekretariat Negara dan Sekretariat Kabinet diintegrasikan ke BRN/PLN.</span></p>
QUO VADIS PENGATURAN KEWENANGAN PENGADILAN TATA USAHA NEGARA DALAM PENERIMAAN PERMOHONAN FIKTIF POSITIF PASCA PENATAAN REGULASI DALAM UNDANG-UNDANG CIPTA KERJA
Authors: Wicaksono Dian Agung , Hantoro Bimo Fajar , Kurniawan Dedy 
Published: October 2022

<span lang="IN">Penataan regulasi dalam Undang-Undang Nomor 11 Tahun 2020 tentang Cipta Kerja (UU CK) dengan metode <em>omnibus law</em> membawa perubahan mendasar dalam penataan peraturan perundang-undangan di Indonesia. Fokus penelitian ini adalah mengenai pengaturan penerimaan permohonan fiktif positif yang sebelumnya diatur dalam Pasal 53 UU Nomor 30 Tahun 2014 tentang Administrasi Pemerintahan (UU AP) yang turut diubah dalam Pasal 175 UU CK. Penelitian ini mencoba menjawab: (a) Bagaimana dinamika pengaturan mengenai fiktif positif dalam sistem hukum Indonesia? (b) Apa implikasi pengaturan penerimaan permohonan fiktif positif dalam Undang-Undang Nomor 11 Tahun 2020 tentang Cipta? Penelitian ini menggunakan metode yuridis normatif, dengan menganalisis data sekunder berupa peraturan perundang-undangan dan pustaka yang terkait dengan fiktif positif dan kewenangan PTUN. Hasil dari penelitian ini menunjukkan bahwa dinamika pengaturan mengenai fiktif positif dapat dilihat sejak diadopsinya KTUN dengan konstruksi fiktif negatif dalam UU Nomor 5 Tahun 1986 dan perubahannya, yang kemudian diubah menjadi KTUN dengan konstruksi fiktif positif dalam UU AP, yang selanjutnya diubah melalui UU CK dengan menghapuskan kewenangan PTUN dalam memutus permohonan penerimaan fiktif positif. Pengaturan penerimaan permohonan fiktif positif dalam UU CK setidaknya membawa implikasi terhadap: (a) hilangnya alas kewenangan PTUN untuk memutus permohonan penerimaan fiktif positif; dan (b) fiksi dianggap telah dikabulkan secara hukum terhadap KTUN dengan konstruksi fiktif positif tanpa putusan PTUN menimbulkan ketidakpastian hukum.</span>
Справник у системі управління Волинською губернією (кінець ХVІІІ – 1860-ті рр.)
Authors: Shevchuk Andrii , Markevych Oksana 
Published: October 2022

Мета статті – висвітлити функціонування інституту справників у Волинській губернії з кінця ХVІІІ ст. і до реформи місцевої поліції 1862 р; охарактеризувати їх повноваження, визначити особливості кадрової політики призначень на цю посаду, охарактеризувати практичну діяльність чиновників.
Наукова новизна – охарактеризовано специфічні завдання справників Волинської губернії, які забезпечували стабільність на новоприєднаних територіях, зроблено аналіз їх кадрового складу та підраховано тривалість перебування на посаді. Зроблено висновки про гнучку кадрову політика верховної влади у регіоні: за потреби здобуття лояльності місцевих еліт надавалася можливість шляхті самостійно формувати корпус справників, у випадку опанування ситуації – центр повертався до бюрократичного принципу.
Висновки: у статті проаналізовано функціонування інституту справників у Волинській губернії ХVІІІ – 60-х рр. ХІХ ст. Розглянуто виконання ними адміністративно-господарських, фіскальних, поліцейських повноважень у повіті й участь у нижньому земському суді. Зазначається, що на відміну від внутрішніх губерній Російської імперії, справники забезпечували ще й політичну стабільність. Верховна влада покладалася на думку справників при визначенні благонадійності шляхти, вони видавали дозволи на виїзд за межі повіту тим полякам, які перебували під слідством, складали звіти про дотримання у польських маєтках інвентарних правил тощо. Справники отримали виняткові повноваження самостійно викликати війська для придушення виступів.
Враховуючи значимість повноважень справників, верховна влада лише у критичних випадках дозволяла виборність посадовців, що ставило їх у залежність від місцевої знаті (1802-1805, 1816-1823). У решти періоди корпус справників формувався за бюрократичним принципом. Вершиною для чиновників був чин титулярного радника, за службу вони нагороджувалися орденами. Традиційними були їх ротації між повітами. Після польського Листопадового повстання шляхта втратила можливість обіймати цю посаду, а остаточне рішення про призначення перейшло до Міністерства внутрішніх справ. На цю посаду стали призначатись військові у відставці, які, на думку влади, могли найліпше впоратись із завданнями нагляду за поляками. Натомість швидко проявилась їх невміння виконувати адміністративно-господарські повноваження, вести діловодство тощо. Колишні військові розглядали службу як можливість швидко та незаконно збагатитися, що зводило нанівець намагання верховної влади пришвидшити інтеграцію краю.
Польські історико-географічні студії у рецепції авторів часопису «Kwartalnik historyczny» (кінець XIX – початок XX ст.)
Authors: Lazurko Lidiia , Hubytskyy Liubomyr 
Published: October 2022

Мета статті – з’ясувати особливості відображення процесу дисциплінарного становлення історичної географії на сторінках часопису «Kwartalnik Historyczny» протягом кінця ХІХ – початку ХХ ст.
Наукова новизна дослідження полягає у тому, що вперше на основі історіографічних матеріалів (досліджень, рецензій, дискусій) здійснено аналіз представлення на сторінках часопису «Kwartalnik Historyczny» історико-географічних проблем, обговорюваних у польській науці наприкінці XIX – початку XX ст.
Висновки. На сторінках часопису «Kwartalnik Historyczny» наприкінці XIX – початку XX ст. активно обговорювались питання історичної географії, головно, у контексті проблем становлення цієї історичної дисципліни. Найперше, на чому акцентували автори часопису, було обговорення завдань історико-географічних досліджень, методів їх провадження та з’ясування місця історичної географії у системі історичної науки. Ми бачимо представлення дуже широкого спектру зацікавлень авторів видання – від обговорення теоретичних підстав нової історичної дисципліни до оцінки науково-популярних видань, що містили інформацію з історичної географії. Прикметною рисою критичних оглядів, публікованих на сторінках часопису «Kwartalnik Historyczny», була зорієнтованість на високі наукові стандарти історіописання та ознайомлення читачів з актуальними європейськими науковими дослідженнями, що також не заважало обговорювати питання історичної географії у контексті актуальних політичних проблем розділеної Польщі.
Allelopathic potential and competitive traits of sweetpotato cultivars
Authors: Werle Isabel S. , Noguera Matheus M. , Karaikal Srikanth K. , Carvalho-Moore Pamela , Kouame Koffi Badou-Jeremie , Tseng Te-Ming , Roma-Burgos Nilda 
Published: October 2022

Allelopathy and competition are components of plant-plant interactions, delimiting the level of interference. Understanding this interaction has practical applications in agriculture. Crop cultivars possessing high allelopathic ability and competitive traits are themselves tools for sustainable weed management, enabling reduced use of herbicides. Greenhouse and field experiments were conducted to assess the weed suppressive ability of selected sweetpotato (Ipomoea batatas L.) cultivars. The effect of nine cultivars on Palmer amaranth (Amaranthus palmeri S. Watson), junglerice (Echinochloa colona L.), and hemp sesbania (Sesbania hederacea P. Mill.) was first evaluated in the greenhouse. The experiment was set up in a completely randomized design with four replications and conducted twice. Sweetpotatoes were cultured in sand. The target weeds were seeded in pots filled with a 2:1 mix of field soil:potting mix and watered with 100-ml aliquot of sweetpotato root leachates once every 2 d. Weed height and shoot biomass were measured. ‘Heartogold’, ‘Centennial’, and ‘Stokes Purple’ were the most allelopathic cultivars. Junglerice was most inhibited by sweetpotato leachates. Nine cultivars were evaluated in the field. Experiments were conducted at Fayetteville and Kibler, Arkansas, USA, in a split-plot design, with weed infestation (broadleaf spp., grass spp., or weed-free) as whole plot and the cultivars as split-plot. Across locations, ‘Beauregard-14’ had the longest vines, whereas ‘Hatteras’ and ‘Heartogold’ had the tallest canopy. ‘Heartogold’ had the largest leaf area. This cultivar reduced weed biomass 2- to 4-fold in both locations. Yield was reduced on average 55 and 68% with grass and broadleaf weeds across locations, respectively. ‘Beauregard-14’ and ‘Bayou Belle-6’were the high-yielding cultivars in Kibler and Fayetteville. The highest yielding cultivars were not the most weed suppressive but did not incur the highest yield loss from weed competition, indicating the ability to withstand weed interference. Cultivar competitiveness, weed-suppressive ability, and weed tolerance are important factors that should be considered before making a cultivar selection.
Infection with the SARS-CoV-2 Omicron variant in children with congenital heart disease: A case series study during Shanghai epidemic
Authors: Yang Yinyu , Wu Yibei , Zhang Wen , Cao Qing , Zhang Haibo , Zhang Hao , Dong Wei 
Published: October 2022

ObjectiveTo analyze the clinical characteristics and prognostic factors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant infections in children with congenital heart disease (CHD).MethodsA retrospective analysis was performed on SARS-CoV-2 Omicron-infected children with CHD who were admitted to Shanghai Children's Medical Center from April 1, 2022 to May 31, 2022. The clinical, laboratory and imaging data, and the nucleic acid conversion time of the children in this group were collected and analyzed.ResultsThirteen patients were included in this study and had an average age of 1.1 (0.16–14) years. Among the patients, 3 patients were preoperatively treated, and 10 were postoperatively treated. According to the severity of the disease, 1 patient was diagnosed with the moderate type, and the remaining 12 patients were diagnosed with the mild type. The clinical symptoms were mostly associated with upper respiratory tract infections, including 13 with fever (100%), 8 with cough (61.8%), 5 with sputum production (38.5%), 1 of shortness of breath (7.7%), etc. All patients were successfully discharged from the hospital, with 16.4 ± 2.9 days needed to obtain cycle threshold (CT) values ≥35 in nucleic acid testing and 17.5 ± 3.6 days of hospitalization.ConclusionsFor vulnerable patients such as children with CHD, SARS-CoV-2 Omicron variant infections mostly present with mild upper respiratory tract symptoms with negative or mildly changed chest imaging. Through appropriate treatment of the underlying disease in the quarantine ward, patients might obtain good outcomes, even after long periods of hospitalization.
Serum peptidomic screening identified circulating peptide biomarkers predictive for preeclampsia
Authors: Zhao Shenglong , Yin Chenghong , Zhai Yanhong , Jia Zhaoxia , Su Shaofei , Lu Yifan , Meng Lanlan , Li Chunbo , Liu Xiang , Cong Yuting , Li Youran , Liu Ying , Chen Lu , Wang Jing , Xu Zhengwen , Zheng Yuanyuan , Sun Zhi , Luo Ruben Y. , Yu Xiaobo , Yang He S. , Liu Xiaowei , Zhao Zhen , Cao Zheng 
Published: October 2022

BackgroundReliable biomarkers are needed to improve preeclampsia (PE) prediction accuracy. With the investigational tool of peptidomics, we aimed to identify and validate potential serum peptide biomarkers in cohorts suspected for PE development in middle or late pregnancy.MethodsTotally 195 serum samples were prospectively collected from pregnant women with PE-related syndromes who were followed up for PE development until delivery. Serum peptidomic analysis was performed in the discovery cohort of 115 samples using matrix-assisted laser desorption ionization-time of flight coupled with Linear Trap Quadropole Orbitrap mass spectrometry. The candidate biomarkers were further validated using an in-house developed liquid chromatography tandem mass spectrometry (LC-MS/MS) method in an independent validation cohort of 80 serum samples.ResultsWe identified 8 peptides that were differentially expressed and originated from fibrinogen alpha chain (FGA), inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) and complement component 3. In the subsequent LC-MS/MS quantitation analysis, the levels of the three peptides (FGA-1033.4, ITIH4-2026.9, ITIH4-2051.1) exhibited a significant difference between the PE-positive and PE-negative groups. Further, the three-peptide panel yielded an area under the ROC curve (AUC) of 0.985 [95% confidence interval (CI) 0.965–1.000] and 0.923 (95% CI 0.845–1.000) in the discovery and validation cohorts respectively, with negative predictive values of 98.1–98.8% and positive predictive values of 73.1–85.3% that were much improved when compared with that of soluble fms-like tyrosine kinase-1/placental growth factor (sFlt-1/PlGF) ratio.ConclusionsWe have discovered and validated a novel three-peptide biomarker panel predictive for the occurrence PE in pregnant women.
Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart disease
Authors: Viloria Mary Audrey D. , Li Qing , Lu Wang , Nhu Nguyen Thanh , Liu Yijie , Cui Zhen-Yang , Cheng Yu-Jung , Lee Shin-Da 
Published: October 2022

ObjectiveCardiac mitochondrial dysfunction was found in ischemic heart disease (IHD). Hence, this study determined the effects of exercise training (ET) on cardiac mitochondrial respiration and cardiac mitochondrial quality control in IHD.MethodsA narrative synthesis was conducted after searching animal studies written in English in three databases (PubMed, Web of Science, and EMBASE) until December 2020. Studies that used aerobic exercise as an intervention for at least 3 weeks and had at least normal, negative (sedentary IHD), and positive (exercise-trained IHD) groups were included. The CAMARADES checklist was used to check the quality of the included studies.ResultsThe 10 included studies (CAMARADES score: 6–7/10) used swimming or treadmill exercise for 3–8 weeks. Seven studies showed that ET ameliorated cardiac mitochondrial respiratory function as manifested by decreased reactive oxygen species (ROS) production and increased complexes I-V activity, superoxide dismutase 2 (SOD2), respiratory control ratio (RCR), NADH dehydrogenase subunits 1 and 6 (ND1/6), Cytochrome B (CytB), and adenosine triphosphate (ATP) production. Ten studies showed that ET improved cardiac mitochondrial quality control in IHD as manifested by enhanced and/or controlled mitochondrial biogenesis, dynamics, and mitophagy. Four other studies showed that ET resulted in better cardiac mitochondrial physiological characteristics.ConclusionExercise training could improve cardiac mitochondrial functions, including respiration, biogenesis, dynamics, and mitophagy in IHD.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=226817, identifier: CRD42021226817.
Clinical manifestations and associated factors in acquired hypoaldosteronism in endocrinological practice
Authors: Ruiz-Sánchez Jorge Gabriel , Calle-Pascual Alfonso Luis , Rubio-Herrera Miguel Ángel , De Miguel Novoa María Paz , Gómez-Hoyos Emilia , Runkle Isabelle 
Published: October 2022

IntroductionHypoaldosteronism can be congenital or acquired, isolated or part of primary adrenal insufficiency, and caused by an aldosterone deficit, resistance, or a combination of both. Reduced mineralocorticoid action can induce a decrease in urine K+ and H+ excretion and an increase in urine Na+ excretion, leading to hyperkalemia, and/or hyponatremia, often combined with metabolic acidosis. We aimed to characterize the clinical manifestations of hypoaldosteronism, and their associated factors.MethodsRetrospective analysis of 112 episodes of hypoaldosteronism diagnosed in 86 adult patients from 2012-2019 by the Endocrinology and Nutrition Department of a tertiary hospital. The frequency of hyperkalemia, hypovolemic hyponatremia (HH) and metabolic acidosis (MA), and their associated factors were evaluated.ResultsPatients had a median age of 77 [65 – 84], 55.4% were male. 94.6% cases showed hyperkalemia, 54.5% HH, and 60.3% MA. The mean serum K+ of all cases was 5.4 ± 0.5 mmol/L, Na+: 132.1 ± 6.3 mmol/L, HCO3: 22.6 ± 3.3 mmol/L. Hypoaldosteronism was isolated in the majority of cases: only 6/112 (5%) had primary adrenal insufficiency. Hypovolemia was associated with hyponatremia and a more florid clinical presentation. HH was associated with a combined presence of aldosterone-lowering and mineralocorticoid resistance factors. MA was associated with the presence of mineralocorticoid resistance factors.ConclusionsHypoaldosteronism in adult endocrinological clinical practice is primarily isolated, and acquired. It predisposes not only to the development of hyperkalemia and MA, but also to that of HH. Hypoaldosteronism must be considered in the differential diagnosis of HH with urinary sodium wasting.
Lactobacillus johnsonii YH1136 plays a protective role against endogenous pathogenic bacteria induced intestinal dysfunction by reconstructing gut microbiota in mice exposed at high altitude
Authors: Wan Zhiqiang , Zhang Xufei , Jia Xianhao , Qin Yuhua , Sun Ning , Xin Jinge , Zeng Yan , Jing Bo , Fang Jing , Pan Kangcheng , Zeng Dong , Bai Yang , Wang Hesong , Ma Hailin , Ni Xueqin 
Published: October 2022

BackgroundIntestinal microbiota plays an important role in maintaining the microecological balance of the gastrointestinal tract in various animals. Disturbances in the intestinal microbiota may lead to the proliferation of potentially pathogenic bacteria that become the dominant species, leading to intestinal immune disorders, intestinal inflammation, and other intestinal diseases. Numerous studies have been confirmed that high-altitude exposure affects the normal function of the intestine and the composition of the intestinal microbiota. However, it is still necessary to reveal the changes in intestinal microbiota in high-altitude exposure environments, and clarify the relationship between the proliferation of potentially pathogenic bacteria and intestinal injury in this environment. In addition, explored probiotics that may have preventive effects against intestinal diseases.Methods and resultsC57BL/6 mice were randomly divided into three groups, a high-altitude group (HA), control group (C), and high-altitude probiotic group (HAP). The HA and HAP groups were subjected to hypoxia modeling for 14 days in a low-pressure oxygen chamber with daily gavage of 0.2 mL of normal saline (HA) and Lactobacillus johnsonii YH1136 bacterial fluid (HAP), while the control group was fed normally. L. johnsonii YH1136 was isolated from feces of a healthy Tibetan girl in Baingoin county, the Nagqu region of the Tibet Autonomous Region, at an altitude of 5000 meters. Our observations revealed that gavage of YH1136 was effective in improving the damage to the intestinal barrier caused by high-altitude exposure to hypoxic environments and helped to reduce the likelihood of pathogenic bacteria infection through the intestinal barrier. It also positively regulates the intestinal microbiota to the extent of Lactobacillus being the dominant microbiome and reducing the number of pathogenic bacteria. By analyzing the expression profile of ileal microRNAs and correlation analysis with intestinal microbiota, we found that Staphylococcus and Corynebacterium1 cooperated with miR-196a-1-3p and miR-3060-3p, respectively, to play a regulatory role in the process of high-altitude hypoxia-induced intestinal injury.ConclusionThese findings revealed the beneficial effect of L. johnsonii YH1136 in preventing potential endogenous pathogenic bacteria-induced intestinal dysfunction in high-altitude environments. The mechanism may be related to the regulation of intestinal injury from the perspective of the gut microbiota as well as miRNAs.
Adherence to Sars-CoV2 vaccination in hematological patients
Authors: Narinx Justine , Houbiers Margaux , Seidel Laurence , Beguin Yves 
Published: October 2022

BackgroundSARS-CoV2 vaccination efficiently prevents severe COVID-19, although hematological patients, particularly under therapy, respond less well. Besides vaccine efficacy, adherence to vaccination is essential for ensuring adequate protection of this vulnerable population.MethodsWe evaluated the impact of a program aimed at maximizing patient adherence by comparing the rate of SARS-CoV2 vaccination of our hematological patients and a matched sample of the general population.ResultsVaccination rates were 88.9% among 2,156 patients, aged 65.2 ± 15.8 years (M ± SD, range 19-86 years). Rates differed considerably with age, i.e. 84.2% between 18-64 years and 92.4% above 65 years (p&lt;0.0001), but not with sex. In the general population, rates were 76.3% overall, 73.0% between 18-64 and 86.7% above 65 years, all significantly lower than among patients, overall (Standardized Incidence ratio (SIR) 1.17; 95%CI 1.12-1.22, p&lt;0.0001) as well as among younger (SIR 1.15; 1.07-1.24, p&lt;0.0001) or older (SIR 1.06; 1.00-1.13, p=0.046) people. Vaccination rates increased to 92.2% overall (SIR 1.21; 1.16-1.27, p&lt;0.0001), 88.5% in younger (SIR 1.21; 1.13-1.30, p&lt;0.0001) and 94.8% in older (SIR 1.09; 1.03-1.12, p=0.0043) patients, after excluding those with medical contraindications, and further to 95.6% overall (SIR 1.26; 1.20-1.32, p&lt;0.0001), 93.8% in younger (SIR 1.29; 1.20-1.38, p&lt;0.0001) and 96.9% in older (SIR 1.11; 1.05-1.18, p=0.0004) patients, after excluding those not seen in hematology in 2021.ConclusionsVaccination rates were significantly higher in hematological patients compared to the general population regardless of age, sex and municipality. Acceptance of Covid vaccines by hematological patients may be improved by targeted information campaigns carried out by trusted health care professionals.