bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Enzymatic Antibiotic Adjuvant Modulates the Infectious Microenvironment to Overcome Antimicrobial Resistance of Pathogens
Authors: Wei Min , Wu Jiahe , Sun Heng , Zhang Bo , Hu Xi , Wang Qiyue , Li Bowen , Xu Lilan , Ma Teng , Gao Jianqing , Li Fangyuan , Ling Daishun 
Published: November 2022

AbstractThe emergence and evolution of antimicrobial resistance (AMR) pose a significant challenge to the current arsenal to fight infection. Antibiotic adjuvants represent an appealing tactic for tackling the AMR of pathogens, however, their practical applications are greatly constrained by the harsh infectious microenvironment. Herein, it is found that silver nanoclusters (Ag NCs) can possess tunable enzymatic activities to modulate infectious microenvironments. Based on this finding, an enzymatic nanoadjuvant (EnzNA) self‐assembled from Ag NCs, which is inert under neutral physiological conditions but can readily disassemble into isolated Ag NCs exhibiting biofilm destructive oxidase‐mimetic activity in the acidic biofilm microenvironment, is developed. Once internalized into the neutral cytoplasm of bacteria, Ag NCs switch to reveal the thiol oxidase‐mimetic activity to suppress ribosomal biogenesis for AMR reversal and evolution inhibition of pathogens. Consequently, EnzNAs revitalize various existing antibiotics against methicillin‐resistant Staphylococcus aureus, and potentiate the antibiotic efficacy against biofilm‐mediated skin infection and lethal lung infection in mice. These findings highlight the capability of enzyme‐mimetic nanomaterials to modulate the infectious microenvironment and potentiate antibiotics, providing a paradigm shift for anti‐infection therapy.
End‐Group Engineering of Chlorine‐Trialkylsiylthienyl Chain‐Substituted Small‐Molecule Donors for High‐Efficiency Ternary Solar Cells
Authors: Li Jing , Zhang Chenyang , Zhong Xiuzun , Deng Wanyuan , Hu Hanlin , Wang Kai 
Published: November 2022

AbstractTernary architecture has been widely demonstrated as a facile and efficient strategy to boost the performance of organic solar cells (OSCs). However, the rational design of the third component with suitable core and end‐group modification is still a challenge. Herein, two new small‐molecule (SM) donors BT‐CN and BT‐ER, featuring the identical conjugated backbone with distinct end group, have been designed, synthesized, and introduced into the PM6:Y6 binary system as the second donor. Both molecules exhibit complementary absorption and good miscibility with PM6, contributing to the nanofibrous phases and strong face‐on molecular packing. Importantly, the incorporation of BT‐CN/BT‐ER has significantly facilitated charge collection and transportation with remarkable suppression of carrier recombination. As a result, ternary OSCs with 20 wt% BT‐CN/BT‐ER achieved a PCE of 16.8%/17.22% with synchronously increased open‐circuit voltage (VOC), short‐circuit current density (JSC) and fill factor (FF). Moreover, replacing Y6 with L8‐BO further improves the PCE to 18.05%/18.11%, indicating the universality of both molecules as the third component. This work demonstrates not only two efficient SM donors with 4,8‐bis(4‐chloro‐5‐(tripropylsilyl)thiophen‐2‐yl) benzo[1,2‐b:4,5‐b′]dithiophene (BDTT‐SiCl) as the core but also end group modification strategy to fine‐tune the absorption spectrum, molecular packing, and energy levels of SM donors to construct high‐performance ternary OSCs.
An evaluation of detection methods for the plains spotted skunk
Authors: Perkins J. Clint , Gibson Alexandra A. , Wolaver Brad D. , Labay Benjamin J. , Pierre Jon Paul , Dowler Robert C. 
Published: November 2022

AbstractResearch on rare or understudied species often benefits from employing multiple survey techniques to ensure highest efficacy in detecting individuals. The plains spotted skunk (Spilogale putorius interrupta) is an uncommon mephitid historically distributed throughout much of Texas, USA. To inform the current distribution of plains spotted skunks in Texas, we integrated occurrence data from natural history collections and field surveys with data from academic, wildlife, and citizen scientist groups, resulting in 286 verified occurrence records from 1892 through 2018. We modeled historic species distribution using 64 records from natural history collections to direct surveying efforts in 13 counties using live traps, camera traps, and track plates. Field surveys and citizen science camera trap surveys resulted in 16 records while crowdsourcing resulted in 23 verified reports detailing 78 unique plains spotted skunk records. Our efforts resulted in a 49% increase in occurrence records from 1892 to 2018 (186–286) and a 1,000% increase in records since 2000 (10–110). Using our methods, researchers and managers can optimize collection of plains spotted skunk occurrence data to better understand the species, produce more robust datasets for future management, and help ensure the best science is used when drafting conservation plans for plains spotted skunks.
Thermal stresses in growing thermoviscoelastic cylinder and their evolution in the course of selective laser melting processing
Authors: Fekry Montaser 
Published: November 2022

AbstractThe evolution in time of stresses and strains in a solid during its manufacturing through selective laser melting (SLM) process is studied. The technological technique, which allows to reduce the intensity of internal and residual stresses is proposed and theoretically grounded. The basic concept of the technique is that the additional in‐homogeneous inductive heating in the vicinity of the growing boundary is applied in the processing. The term “growing boundary” refers to the part of the boundary, on which the additional melted material is added. The evolutionary problem for a growing thermoelastic body is considered in approach of thermal stresses (for slow additive processes) and in the approach of full coupled thermoelasticity (for fast processing). The time depend distribution of internal stresses and their residual counterparts has been evaluated in analytical form in the case of model cylindrical problem. The analysis of the influence of frequency and amplitude of electromagnetic induction as well as viscoelastic properties of heated material being added has been carried out. The results are analyzed numerically for Titanium and Copper materials.
Sharing Is Caring: Living with Friends and Heterotopic Citizenship
Authors: Santos Ana Lúcia 
Published: November 2022

AbstractDrawing on biographic interviews conducted with LGBTQ people based in Lisbon, this chapter unpacks the reasons why people cohabit with friends. The chapter starts with an introduction to the topic of friendship and how it has been historically constructed in Western societies. The second part draws attention to the empirical experience of living with friends. To understand why and how people manage cohabiting with friends, a focus will be placed on recent processes of gentrification and on the dynamics of care. Towards the end of the chapter, it will be suggested that houses designed to host nuclear families are heterotopic spaces where a variety of social practices occur.
Affective Trans Relationships: Towards a Deleuzian Approach to Friendship Theory
Authors: Davy Zowie 
Published: November 2022

AbstractThis chapter challenges mainstream friendship theory from philosophy and psychosocial studies that seems to suggest that at school friendship is based on hierarchized types of relationship. Drawing on data from parents of trans and gender-diverse children, this chapter demonstrates that friendship and friendship bonds cannot be universalized and that we must acknowledge the different desires, choices, and lived experiences through time and space, the roles, and the desires that are produced in an ongoing way within friendship relationships and that they are constantly moving. I argue that by looking at these friendship affects through a Deleuzian lens we are able to enunciate how friendships are, according to the parents, affective and becoming minoritarian and thus producing new ways to think about friends and friendship bonds.
Bisexual Citizenship in Portugal
Authors: Esteves Mafalda 
Published: November 2022

AbstractPortugal has achieved significant legal changes in LGBTI+ rights. However, bisexuality is still regarded as suspicious, leading to invisibility and silence. This chapter analyses bisexual citizenship in Portugal, starting with the theoretical debate around this concept and subsequently taking intimate citizenship as a useful analytical concept in uncovering the institutionalization of compulsory heterosexuality and monosexuality. Through the lens of an empirical study based on ongoing PhD research, it analyses bisexual citizenship and explores how bisexual people construct and express their intimate citizenship. Focused on the challenges and constraints faced by bisexual activism in Portugal, analysed data will feed the theoretical debate on intimate citizenship in Portugal and contribute to (re)thinking about the status of bisexual people as sexual subjects.
Biocriminals, Racism, and the Law: Friendship as Public Disorder
Authors: Pérez Navarro Pablo 
Published: November 2022

AbstractThis essay offers a reading of the notion of public order from a biopolitical point of view. Departing from Giorgio Agamben’s reading of the state of exception, it will be argued that public order is the legal dispositive allowing for sovereign power to disseminate in a microphysical form throughout the judicial, administrative and securitarian institutions of the state. Moreover, in a similar vein that the state of exception constitutes, for Agamben, a threshold between the order of the law and the order of life, it will be shown that public order represents a fundamental core of Eurocentric regulations of the social life of kinship, gender, and reproduction. Finally, I will contrast the biopolitics of public order, understood as a preserving force for the status quo, with Foucault’s account of friendship, understood as an ever-emerging impulse for creative forms of radical cohabitation.
Embodied Queer Epistemologies: A New Approach to (a Monstrous) Citizenship
Authors: Santos Ana Cristina 
Published: November 2022

AbstractIn this chapter meanings attached to monstrosity will be explored in light of queer critiques of the concept of citizenship. The first part of the chapter explores the notion of the monster, with a particular interest in queer readings of monstrosity. In that section, monsters will be unpacked against the backdrop of the archetype of the hero. Subsequently, the chapter focuses on the idea of citizenship and aims at recuperating its potential in the light of both contemporary queer critiques and evidence-based needs to strengthen formal recognition in times of anti-LGBTQI+ backlash. Finally, the notion of monstrous citizenship will be advanced as part of what I am suggesting be interpreted as an embodied turn in (queer) epistemologies.
Building Safer Spaces: Daily Strategies and Networks of Care in Cisheteronormative Italy
Authors: Motterle Tatiana 
Published: November 2022

AbstractThe chapter outlines the undeniable importance of affects, friendships, collective and mutual care and support among LGBTQ people in Italy, reading them as forms of resistance to the general absence of a formal recognition of LGBTQ rights by the Italian state or to the limits of existing legislation. The author starts by introducing some relevant characteristics of the Italian socio-economic and political context and their consequences on the rights and the intimate lives of LGBTQ people. The text then explores the stories of participants, first describing the material and symbolic consequences of the lack of laws protecting LGBTQ rights and then identifying and unpacking some strategies through which participants cope in daily life, namely, working around the law and building networks of care.
Insurgent Parenting: Political Implications of Childrearing and Caring Practices in Spain
Authors: Moreira Luciana 
Published: November 2022

AbstractContemporary Western societies have accommodated relational rights of queer people, but the link between marriage and filiation rights remains strong. However, parallel to significant alternative family projects that emerged from Black and lesbian feminist studies, current possibilities of parenting enabled by intimate citizenship rights also present interesting practices of care outside the traditional family norm. Drawing on interviews with lesbian and bisexual mothers, and with trans people whose parents were part of their networks of care, this chapter analyses how parenting practices may be a tool to (1) ascribe social visibility to sexual and gender-diverse identities and families; (2) educate children beyond a gender binary system; (3) subvert the neoliberal supremacy of paid work over motherhood; and (4) raise children in a larger network of care, beyond the couple/children norm.
Switzerland and the Two Faces of Integration
Authors: Mexi Maria M. 
Published: November 2022

AbstractIn recent years, awareness of the socio-economic costs of immigrants’ marginalisation and exclusion has led Swiss policymakers to promote integration. However, the biographical interviews with migrants, refugees, and asylum seekers (MRAs) who arrived in Switzerland between 2014 and 2019 tell a different story. MRAs consider themselves not well integrated, while the labour market outcomes of certain migrant groups are diverging. Particularly migrant women run the risk of being left behind. This chapter sheds light on these aspects. It also argues that policymaking can only be effective if it considers all structural and agential factors in their interdependence. The chapter illuminates a discrepancy between, on one hand, structural changes that do not always shape aspirations of Swiss policy actors for successful and promising policy implementation and, on the other, the realities of the migrants’ lives. Their experiences of deskilling and a consequent feeling of not being welcome lead to the development of negative epiphanic views on the inability to access gainful employment. The illuminated synergistic relationship between structural and agential factors are very instructive for policymaking: leaving agential considerations outside the scope of structural reforms can expose migrants to further risks and vulnerabilities, and exacerbate inequalities within host societies.
Italy: The Promised Land? Journeys of Migrants, Refugees and Asylum Seekers Towards Labour Market Integration
Authors: Collini Mattia 
Published: November 2022

AbstractMigrants and asylum seekers have faced important hurdles in integrating in the Italian labour market. The segmented and ethnicised nature of this coupled with their often-uncertain residence status significantly contribute to such difficulties. Building on previous studies that looked at the role of policies and structural factors in migrants’ labour market integration, this chapter adopts a biographical perspective to investigate how pre-migration experiences as well as turning points after arriving in Italy have shaped migrants’ and asylum seekers’ labour market integration trajectories. Using biographical narratives, we look at specific events and actors (people or organisations) that marked turning points and provoked epiphanies – whether negative or positive – for the migrant. Our findings highlight the fragmentation of the Italian labour market and the many hurdles that migrants experience. They also highlight how pre-departure experiences and networks at destination contribute to building migrants’ resilience and help them turn their migration experience into a positive one.
A Long Journey of Integration
Authors: Isaakyan Irina , Triandafyllidou Anna , Baglioni Simone 
Published: November 2022

AbstractThis chapter summarizes the interaction between integration and agency by comparing migrants’ encounters with labour markets through which their agency challenges existing discourses. The chapter investigates the complex relationship between policy discourse, gender, and class in the production of migrant agency across different countries. The gendered experiences of low labour in Denmark centre around the crucial moments of retraining for migrant women, through which they reconsider their adjustment to the labour market as ‘devoid integration’. The EU discourses of integration are further disrupted by humanitarian migrants in Scotland and Switzerland, whose encounters with the non-recognition of qualifications and inadequate social welfare contradict the ‘migrant-welcoming’ national facades. The Canadian grand discourse of ‘smooth transition’ is opposed by the analysis of aspirations that clash with outcomes such as the labour market entrance. In this connection, we can see the Italian ‘borderline’ space of the informal market, within which many legal economic migrants navigate a complex web of existing laws and informal opportunities. The comparison is amplified by a visually ‘successful’ portrait of entrepreneurial integration, which is nevertheless perceived by skilled migrants in Finland as a less desirable option. The quality of migrants’ agency thus becomes contested if they seek to progress in the labour market. An essential element in this contestation is the transnational migrants’ disagreement with official discourses of ethnic solidarity and national citizenship in the Czech Republic. The comparative analysis of these lived experiences leads toward a new understanding of ‘agency’ and ‘resilience’ in labour market integration.
Exploring the strong-coupling region of SU(N) Seiberg-Witten theory
Authors: D’Hoker Eric , Dumitrescu Thomas T. , Nardoni Emily 
Published: November 2022

Abstract
We consider the Seiberg-Witten solution of pure $$ \mathcal{N} $$
N
= 2 gauge theory in four dimensions, with gauge group SU(N). A simple exact series expansion for the dependence of the 2(N − 1) Seiberg-Witten periods aI(u), aDI(u) on the N − 1 Coulomb-branch moduli un is obtained around the ℤ2N-symmetric point of the Coulomb branch, where all un vanish. This generalizes earlier results for N = 2 in terms of hypergeometric functions, and for N = 3 in terms of Appell functions. Using these and other analytical results, combined with numerical computations, we explore the global structure of the Kähler potential K = $$ \frac{1}{2}{\sum}_I $$

1
2

∑
I

Im($$ \overline{a} $$

a
¯

IaDI), which is single valued on the Coulomb branch. Evidence is presented that K is a convex function, with a unique minimum at the ℤ2N-symmetric point. Finally, we explore candidate walls of marginal stability in the vicinity of this point, and their relation to the surface of vanishing Kähler potential.
A randomized phase 2 trial of nintedanib and low-dose cytarabine in elderly patients with acute myeloid leukemia ineligible for intensive chemotherapy
Authors: Berdel Andrew F. , Koch Raphael , Gerss Joachim , Hentrich Marcus , Peceny Rudolf , Bartscht Tobias , Steffen Björn , Bischoff Marina , Spiekermann Karsten , Angenendt Linus , Mikesch Jan-Henrik , Kewitz Tobias , Butterfass-Bahloul Trude , Serve Hubert , Lenz Georg , Berdel Wolfgang E. , Krug Utz , Schliemann Christoph 
Published: November 2022

AbstractWe investigated the safety and efficacy of nintedanib added to low-dose cytarabine (LDAC) in a phase 1/2 study in patients 60 years or older with newly diagnosed or relapsed/refractory (r/r) AML ineligible for intensive chemotherapy. The results of the dose-finding phase 1 part have been previously published. Patients were randomized 1:1 to LDAC plus nintedanib or LDAC plus placebo stratified by AML status (newly diagnosed vs r/r). LDAC was applied subcutaneously at 20 mg twice daily on days 1 to 10. Nintedanib/placebo was orally administered twice daily on days 1 to 28 in 28-day cycles. The primary endpoint was overall survival (OS). Between 05/2017 and 09/2019, 31 patients were randomized and 30 were treated, before the study was terminated prematurely due to slow recruitment. Median (range) age of patients was 76 (60–84) years. Twenty-two patients (73%) had r/r AML. Median OS in patients treated with LDAC and nintedanib was 3.4 months, compared with 3.6 months in those treated in the placebo arm, with a HR adjusted for AML status of 1.19 (corresponding confirmatory adjusted 95% CI, 0.55–2.56; univariate log-rank P = 0.96). In the 22 patients with r/r AML, median OS was 3.0 months in the nintedanib and 3.6 months in the placebo arm (P = 0.36). One patient in the nintedanib and two patients in the placebo arm achieved a CR and entered maintenance treatment. Nintedanib showed no superior therapeutic activity over placebo when added to LDAC in elderly AML patients considered unfit for intensive chemotherapy. The trial was registered at clinicaltrials.gov NCT01488344.
Final 4-year results of the RAINBOW real-world study: intravitreal aflibercept dosing regimens in France in treatment-naïve patients with neovascular age-related macular degeneration
Authors: Cohen Salomon-Yves , Dominguez Marcel , Coscas Florence , Faure Céline , Baillif Stéphanie , Oubraham Hassiba , Kodjikian Laurent , Weber Michel ,   on behalf of the RAINBOW study investigators
Published: November 2022

Abstract
Purpose
The purpose of this study is to evaluate real-world treatment outcomes in patients with neovascular age-related macular degeneration (nAMD) treated with intravitreal aflibercept (IVT-AFL) in routine clinical practice in France.

Methods
RAINBOW (NCT02279537) was an ambispective, observational, 4-year study assessing IVT-AFL effectiveness, treatment patterns, and safety in patients with nAMD in France. Treatment-naïve patients prescribed IVT-AFL and treated according to local practice (pro re nata or treat-and-extend) were eligible. Three treatment cohorts were retrospectively identified based on their treatment pattern within the first 12 months: regular (3 initial monthly IVT-AFL injections received within 45–90 days after the first injection in month 0 and followed by injections every 2 months), irregular with the initial monthly injections, and irregular without the initial monthly injections. The primary endpoint was mean change in best-corrected visual acuity (BCVA) from baseline to month 12. The 48-month results are described here.

Results
Overall, the study included 516 patients (each with one study eye), and 30.2% of patients completed 48 months of IVT-AFL treatment. Mean change in BCVA from baseline (56.5 letters) to month 48 for patients with an assessment at both time points was + 1.1 (regular cohort, n = 47), + 0.1 (irregular cohort with initial monthly injections, n = 115), and − 1.3 letters (irregular cohort without initial monthly injections, n = 26), representing a decrease from the gains achieved at month 12. Mean number of IVT-AFL injections received by month 48 in the treatment cohorts was 14.9, 13.7, and 11.9, respectively. The safety profile of IVT-AFL was consistent with previous studies.

Conclusion
In RAINBOW, the 48-month results demonstrate a lack of long-term effectiveness of IVT-AFL treatment of nAMD due to progressive undertreatment in routine clinical practice in France. These real-world findings highlight the importance of 3 initial monthly IVT-AFL injections followed by continuous proactive treatment beyond the first year to achieve optimal functional outcomes.

Trial registration number
ClinicalTrials.gov Identifier: NCT02279537.