bluuebunny/crossref_metadata_2025_split huggingface dataset:
Speech Disorder in Anterior Open Bite (AOB): Systematic Review
Authors: Sari Nendika Dyah Ayu Murika , Utomo Rinaldi Budi 
Published: November 2022

There have been numerous researches showing that articulation disorders and malocclusion are linked. The most prevalent malocclusion in speech or articulation disorders is anterior open bite (AOB). Excessive propulsion of the tongue forward when articulating phonemes causes altered articulation in patients with open bites, as the tongue is in a more forward posture. The presence of this speech disorder can have a negative impact on a person's quality of life, although there hasn't been much research done on the impacts of AOB in cases of speech disorders in children. This study was to look at the link between speech disorders and the occurrence of anterior open bites (AOB) in a comprehensive way. Search results of research on four databases, namely ScienDirect, PubMed, Spingerlink, and Google Scholar, are displayed. The keywords used include speech disorder, articulation disorder, open bite, anterior open bite. Five articles were selected using case control and cross-sectional methods in their research. The sample with AOB in this study was analyzed to determine the presence of speech disorders. The five articles gave similar results, showing that patients with malocclusion, especially AOB, had a tendency to have speech disorders. Articulation disorders in the phoneme /s/z/d/l/t/ become the dominant problem experienced by patients with AOB. Anterior open bite (AOB) is a form of malocclusion that causes more articulation disorders than other malocclusions. The presence and position of the tongue are thought to have a substantial influence on articulation disorders.
Macroeconomic Analysis Model, Financial Performance Against Share Traded With Profit as an Intervening Variable in Food and Beverage Sub-Sector Companies on The Indonesia Stock Exchange Period 2016 - 2020
Authors: Surono Yunan , Akbar Ali , Albetris Albetris , Adisetiawan R. 
Published: November 2022

Smart investors will consider several aspects before investing to avoid the worst possibilities including the company's financial performance. This research aims to look at the macroeconomic analysis model, financial performance against share traded with profit as an intervening variable in food and beverage sub-sector companies in the Indonesia stock exchange for the period 2016 - 2020. Macroeconomic variables will be proxyed with indicators of inflation, exchange rates, interest rates and the money supply. Financial performance variables with current ratio indicators, quick ratio (proxy of liquidity), debt to assets ratio, debt to equity ratio (proxy of solvency), total assets turnover, fixed assets turnover and inventory turnover (proxy of activity), return on asset, return on equity, net profit margin, gross profit margin and operating profit margin (proxy of profitability) and earnings per share, price earning ratio and price book value (proxy of market value). The investment approach can also be done by analyzing historical data from stock prices and linking it to share traded that occurs in the market. The research will use profit as an intervening variable, consisting of gross profit, operating profit and net profit. The company has different performance with significant differences in the food and baverages sub-sector, will affect the amount of sales and profits earned by the company. This research data uses secondary data published by relevant and competent parties. This study uses a component-based SEM (Structural Equation Modeling) analysis or variance, namely Partial Least Square (PLS), using Smart PLS 3.0 software. The results showed 1) macroeconomic variables had no effect on financial performance. 2) Macroeconomic variables have no effect on profits. 3) Macroeconomic variables have no effect on share traded. 4) Financial performance variables affect profits. 5) Financial performance variables affect share traded. 6) The profit variable affects the traded share.
Pemilihan Operator Terbaik Menggunakan Metode Profile Matching
Authors: Dewa Ayu Diah Saraswati  , Kurniawati Laela , Tuti Haryanti  
Published: November 2022

Kemajuan sebuah perusahaan sangat dipengaruhi oleh kualitas sumber daya manusia, salah satunya adalah operator yang bekerja dan mengabdi di dalam perusahaan. Untuk dapat mewujudkan suatu keberhasilan dalam sebuah perusahaan tentunya operator harus memiliki kinerja yang baik dan berkualitas. Permasalahan pengolahan data pada PT. Panggilan Burung Kutilang untuk penilaian operator terbaik yang dilakukan secara manual adalah dapat menyebabkan hasil penilaian operator yang diperoleh bersifat subjektif. Penilaian yang subjektif dianggap tidak akurat dan tidak tepat karena penilaian yang dilakukan pada umumnya mendapatkan hasil yang diperoleh berdasarkan duga-duga, sesuai perasaan atau selera manusia itu sendiri tanpa menilai berdasarkan kriteria-kriteria tertentu. Ada beberapa kriteria penilaian dalam pemilihan operator terbaik yang bisa dilihat dari dua aspek, yaitu: Aspek pertama adalah aspek kinerja meliputi prosedur kerja, kehadiran dan kemampuan. Aspek kedua adalah aspek sikap kerja meliputi kesopanan, kedisplinan, kejujuran dan kerjasama. Tujuan dari penelitian ini adalah untuk membantu perusahaan dalam menentukan operator terbaik pada perusahaan dengan melakukan penilaian yang tidak subjektif dan menghasilkan penilaian yang tepat dan akurat. Dalam melakukan pemilihan operator terbaik salah satunya dapat menggunakan metode Profile Matching, metode ini dapat menjadi solusi agar pemilihan operator lebih tepat dan akurat dengan penilaian yang baik dan proses pengambilan keputusan yang cepat dan tepat. Hasil penelitian yang telah dilakukan dengan menggunakan metode profile matching dalam pemilihan operator terbaik adalah operator terbaik berdasarkan hasil akhir perangkingan dengan memperoleh nilai rata-rata tertinggi yaitu 4,7.
Study of the anticancer effect of new quinazolinone hydrazine derivatives as receptor tyrosine kinase inhibitors
Authors: Mortazavi Motahareh , Divar Masoumeh , Damghani Tahereh , Moosavi Fatemeh , Saso Luciano , Pirhadi Somayeh , Khoshneviszadeh Mehdi , Edraki Najmeh , Firuzi Omidreza 
Published: November 2022

The advent of novel receptor tyrosine kinase inhibitors has provided an important therapeutic tool for cancer patients. In this study, a series of quinazolinone hydrazide triazole derivatives were designed and synthesized as novel MET (c-MET) receptor tyrosine kinase inhibitors. The antiproliferative effect of the synthesized compounds was examined against EBC-1, A549, HT-29 and U-87MG cells by MTT assay. MET kinase inhibitory effect was tested by a Homogenous Time Resolved Fluorescence (HTRF) assay. The antiproliferative effect of compounds in a three-dimensional spheroid culture was studied by acid phosphatase (APH) assay, while apoptosis induction was examined by Hoechst 33258 staining. We found that compound CM9 bearing p-bromo benzyl pendant inhibited MET kinase activity at the concentrations of 10–50 μM (% Inhibition = 37.1–66.3%). Compound CM9 showed antiproliferative effect against cancer cells, in particular lung cancer cells with MET amplification (EBC-1) with an IC50 value of 8.6 μM. Moreover, this derivative inhibited cell growth in spheroid cultures in a dose-dependent manner and induced apoptosis in cancer cells. Assessment of inhibitory effect of CM9 against a panel of 18 different protein kinases demonstrated that this compound also inhibits ALK, AXL, FGFR1, FLT1 (VEGFR1) and FLT4 (VEGFR3) more than 50% at 25 μM. Finally, molecular docking and dynamics simulation corroborated the experimental findings and showed critical structural features for the interactions between CM9 and target kinases. The findings of this study present quinazolinone hydrazide triazole derivatives as kinase inhibitors with considerable anticancer effects.
Videoconferencing fatigue and online student engagement among Filipino senior high school students: A mixed methods study
Authors: Dacillo Mikaela Jasmin F. , Dizon Jhoana Katrina M. , Ong Earl Johann T. , Pingol Althea Mae L. , Cleofas Jerome V. 
Published: November 2022

IntroductionThe ubiquity of online classes during the COVID-19 pandemic induced the widespread use of videoconferencing applications. However, the prolonged use of these applications can lead to videoconferencing fatigue. Drawing from an online survey sample of 215 senior high school students from a selected private university in Manila, Philippines, this mixed methods study examines videoconferencing fatigue and its relationship with online student engagement (OSE) during the COVID-19 pandemic.Materials and methodsThis study utilized a convergent triangulation research design. The quantitative strand was cross-sectional in nature. The constructs were measured using the Zoom Exhaustion and Fatigue Scale and Online Student Engagement Scale. Bivariate and multivariate statistical tests were used to determine the significance of the relationships between variables. The qualitative strand utilized a descriptive design. Narrative data were collected through an open-ended survey question and analyzed using content analysis.ResultsQuantitative results indicate moderate to high levels of videoconferencing fatigue among student respondents. Moreover, higher levels of OSE were observed among those who endured higher visual fatigue and attended videoconferences more days a week. Qualitative findings demonstrate various manifestations of videoconferencing fatigue among students and relate it with decreased energy to perform academic tasks and learning absorption. However, the qualitative analysis also reveals students’ perceived need for videoconferencing to learn online.DiscussionThe nuanced insights from both strands highlight that despite their perceived negative impacts of videoconferencing, students had to tolerate visual videoconferencing fatigue in order to engage meaningfully in online classes.
Advancing real-time pH sensing capabilities to monitor coastal acidification as measured in a productive and dynamic estuary (Ría de Arousa, NW Spain)
Authors: Velo Anton , Padin Xose Antonio 
Published: November 2022

Ocean acidification has critical impacts on marine ecosystems, but presents knowledge gaps on the ecological impacts requiring large-scale monitoring of physicochemical conditions to predict biological responses to ocean pH projections. The threat is especially significant in coastal regions like upwelling areas which are more sensitive and appear to respond more rapidly to anthropogenic perturbations. These ecosystems, such as the northwest coast of the Iberian Peninsula are characterized by complex physical and biogeochemical interactions, supporting enormous biological productivity and productive fisheries. The distribution of pH in upwelling systems has high variability on short temporal and spatial scales preventing a complete picture of acidification, which exhibit long-term pH rates markedly different from the measured in open waters. This motivation to significantly expand the coverage of pH monitoring in coastal areas has driven us to develop an autonomous pH monitoring instrument (from now on SURCOM) based on the Honeywell Durafet® pH electrode. A relevant feature is that SURCOM transmits near real-time pH and temperature measurements every 10.5 min through SIGFOX®, a low-power, low-bandwidth network for data transmission. This very careful design allows us to achieve a very low power consumption for the complete system resulting in 3 years of full autonomy with no other need than external cleaning and calibration. In this paper we describe the setup and the data set obtained by a SURCOM instrument over 240 days in a highly productive and dynamic coastal ecosystem, the Ría de Arousa embayment, providing valuable information on the performance of these low-cost and highly stable sensors, with potential for improving the pH variability description in nearshore systems and for reinforcing the monitoring-modeling of coastal acidification.
Using inflammatory index to distinguish asthma, asthma-COPD overlap and COPD: A retrospective observational study
Authors: Ma Haiman , Yang Liu , Liu Lingli , Zhou Ying , Guo Xiaoya , Wu Shuo , Zhang Xiaoxiao , Xu Xi , Ti Xinyu , Qu Shuoyao 
Published: November 2022

BackgroundAlthough asthma and chronic obstructive pulmonary disease (COPD) are two well-defined and distinct diseases, some patients present combined clinical features of both asthma and COPD, particularly in smokers and the elderly, a condition termed as asthma-COPD overlap (ACO). However, the definition of ACO is yet to be established and clinical guidelines to identify and manage ACO remain controversial. Therefore, in this study, inflammatory biomarkers were established to distinguish asthma, ACO, and COPD, and their relationship with the severity of patients’ symptoms and pulmonary function were explored.Materials and methodsA total of 178 patients, diagnosed with asthma (n = 38), ACO (n = 44), and COPD (n = 96) between January 2021 to June 2022, were enrolled in this study. The patients’ pulmonary function was examined and routine blood samples were taken for the analysis of inflammatory indexes. Logistic regression analysis was used to establish inflammatory biomarkers for distinguishing asthma, ACO, and COPD; linear regression analysis was used to analyze the relationship between inflammatory indexes and symptom severity and pulmonary function.ResultThe results showed that, compared with ACO, the higher the indexes of platelet, neutrophil-lymphocyte ratio (NLR) and eosinophil-basophil ratio (EBR), the more likely the possibility of asthma and COPD in patients, while the higher the eosinophils, the less likely the possibility of asthma and COPD. Hemoglobin and lymphocyte-monocyte ratio (LMR) were negatively correlated with the severity of patients’ symptoms, while platelet-lymphocyte ratio (PLR) was negatively correlated with forced expiratory volume in the 1 s/forced vital capacity (FEV1/FVC) and FEV1 percent predicted (% pred), and EBR was positively correlated with FEV1% pred.ConclusionInflammatory indexes are biomarkers for distinguishing asthma, ACO, and COPD, which are of clinical significance in therapeutic strategies and prognosis evaluation.
Comprehensive analysis of dysregulated circular RNAs and construction of a ceRNA network involved in the pathology of Alzheimer’s disease in a 5 × FAD mouse model
Authors: Sun Ting , Zeng Li , Cai Zhongdi , Liu Qingshan , Li Zhuorong , Liu Rui 
Published: November 2022

IntroductionAlzheimer’s disease (AD) causes a decline in cognitive function that poses a significant hazard to human health. However, the exact pathogenesis of AD and effective treatment have both proven elusive. Circular RNAs (circRNAs), which were initially deemed as meaningless non-coding RNAs, have been shown to participate in a variety of physiological and pathological processes. However, the variations and characteristics of circRNAs are not fairly well understood during the occurrence and development of AD.MethodsIn this study, we performed RNA sequencing analyses, identified circRNA expression profiles, and explored the circRNA-associated competing endogenous RNA (ceRNA) relationship in the hippocampus of five familial AD (5 × FAD) mice with cognitive dysfunction.ResultsThe RNA sequencing results identified 34 dysregulated circRNAs in the hippocampus of 5 × FAD mice, including 17 upregulated and 17 downregulated circRNAs. The circRNA-miRNA interaction network for the dysregulated circRNAs was generated, and it was found to include 34 circRNAs and 711 miRNAs. Next, 2067 mRNAs potentially modulated by upregulated circRNA-interacting miRNAs and 2297 mRNAs potentially modulated by downregulated circRNA-interacting miRNAs were identified. Pathway enrichment analyses revealed that the circRNA-miRNA-mRNA network modulated AD development via multiple pathways, such as axon guidance, mitogen-activated protein kinase, and neurotrophin. The associated biological processes were mainly related to neuron projection development, cell morphogenesis, and head development. Their corresponding distributions were especially high in the axon, postsynapse, and neuronal body. We constructed a ceRNA network that included five circRNAs, four miRNAs, and 188 mRNAs. In this network, the differential expressions of three circRNAs (circRNA04655, circRNA00723, and circRNA01891), two miRNAs (miR-3470b and miR-6240), and 13 mRNAs (Vgll3, Nhsl2, Rab7, Tardbp, Vps33b, Fam107a, Tacr1, Ankrd40, Creb1, Snap23, Csnk1a1, Bmi1, and Bfar) in the hippocampus of 5 × FAD mice using qRT-PCR analyses were consistent with the RNA sequencing results. Another one circRNAs (circRNA00747) and two mRNAs (Zfp37 and Polr1e) had similar expression trends to the sequencing data, while circRNA03723 and Mapk10 had deviated expression trends to the sequencing data.ConclusionsIn conclusion, our study uncovered dysregulated circRNA expression profiles in the hippocampus of 5 × FAD mice, stretched comprehension of ceRNA biology, investigated the potential role of this ceRNA network in pathogenesis and progression, and identified potential biomarkers and therapeutic targets for AD.
Human nasal olfactory stem cells, purified as advanced therapy medicinal products, improve neuronal differentiation
Authors: Jaloux Charlotte , Bonnet Maxime , Vogtensperger Marie , Witters Marie , Veran Julie , Giraudo Laurent , Sabatier Florence , Michel Justin , Legré Regis , Guiraudie-Capraz Gaëlle , Féron François 
Published: November 2022

BackgroundOlfactory ecto-mesenchymal stem cells (OE-MSC) are mesenchymal stem cells derived from the lamina propria of the nasal mucosa. They display neurogenic and immunomodulatory properties and were shown to induce recovery in animal models of spinal cord trauma, hearing loss, Parkinsons’s disease, amnesia, and peripheral nerve injury. As a step toward clinical practice, we sought to (i) devise a culture protocol that meets the requirements set by human health agencies and (ii) assess the efficacy of stem cells on neuron differentiation.MethodsNasal olfactory mucosa biopsies from three donors were used to design and validate the good manufacturing process for purifying stem cells. All processes and procedures were performed by expert staff from the cell therapy laboratory of the public hospital of Marseille (AP-HM), according to aseptic handling manipulations. Premises, materials and air were kept clean at all times to avoid cross-contamination, accidents, or even fatalities. Purified stem cells were cultivated for 24 or 48 h and conditioned media were collected before being added to the culture medium of the neuroblastoma cell line Neuro2a.ResultsCompared to the explant culture-based protocol, enzymatic digestion provides higher cell numbers more rapidly and is less prone to contamination. The use of platelet lysate in place of fetal calf serum is effective in promoting higher cell proliferation (the percentage of CFU-F progenitors is 15.5%), with the optimal percentage of platelet lysate being 10%. Cultured OE-MSCs do not show chromosomal rearrangement and, as expected, express the usual phenotypic markers of mesenchymal stem cells. When incorporated in standard culture medium, the conditioned medium of purified OE-MSCs promotes cell differentiation of Neuro2a neuroblastoma cells.ConclusionWe developed a safer and more efficient manufacturing process for clinical grade olfactory stem cells. With this protocol, human OE-MSCs will soon be used in a Phase I clinical based on their autologous transplantation in digital nerves with a neglected injury. However, further studies are required to unveil the underlying mechanisms of action.
Fish oil and probiotics supplementation through milk chocolate improves spatial learning and memory in male Wistar rats
Authors: Faccinetto-Beltrán Paulinna , Aguirre-López Luis Octavio , Bañuelos-Pineda Jacinto , Reza-Zaldívar Edwin E. , Santacruz Arlette , Hernández-Brenes Carmen , Pérez-Carrillo Esther , Jacobo-Velázquez Daniel A. 
Published: November 2022

BackgroundCognition and brain function is critical through childhood and should be improved with balanced diets. Incorporating bioactive ingredients such as omega-3 polyunsaturated fatty acids (ω3 PUFAs) and probiotics into food formulations could be used as an approach to improve cognitive function. This study evaluated the effects on cognitive capacity of complementing rodent diets with chocolate, by itself and in combination with ω3 PUFAs from fish oil and probiotics.MethodsSpatial learning and memory in the rats were determined by the Barnes maze test in short- and long-term memory. Samples from the cecum were obtained to assess microbial counts (Lactobacillus, Bifidobacterium, Enterobacteriaceae, and total bacteria), and brains were recovered to analyze the neural morphology of the tissues. Also, glucose, brain weights, and epididymal tissue were analyzed.ResultsThe combination of chocolate with fish oil and probiotics improved the memory of rats compared to the result of each bioactive compound when evaluated separately. Treatments did not affect sugar level, epididymal adipose tissue, or brain weight. On the other hand, consuming probiotics alone or in combination with chocolate decreased Enterobacteria counts, while Lactobacillus and Bifidobacteria counts were not affected. Neural morphological analysis showed that combining chocolate with probiotics and ω3 PUFAs increased the number of neurons in the hippocampal CA1 and CA3 regions.ConclusionChocolate added with probiotics and ω3 PUFAs improved spatial memory and learning in the studied model.
Circulating tumor DNA mutation profile is associated with the prognosis and treatment response of Chinese patients with newly diagnosed diffuse large B-cell lymphoma
Authors: Guan Tao , Zhang Min , Liu Xiaolan , Li Jing , Xin Beibei , Ren Yanxin , Yang Yuchao , Wang Hui , Zhao Mengjing , Huang Yunpeng , Guo Xiaojing , Du Jun , Qian Wenbin , Su Liping 
Published: November 2022

BackgroundCharacterization of gene mutation profiles can provide new treatment options for patients with diffuse large B-cell lymphoma (DLBCL). However, this method is challenged by the limited source of tissue specimens, especially those of DLBCL patients at advanced stages. Therefore, in the current study, we aimed to describe the gene mutation landscape of DLBCL using circulating tumor DNA (ctDNA) samples obtained from patients’ blood samples, as well as to explore the relationship between ctDNA mutations and the prognosis and treatment response of patients with newly diagnosed DLBCL.MethodsA total of 169 newly diagnosed Chinese DLBCL patients were included in this study, among which 85 patients were divided into a training set and 84 were assigned into a validation set. The mutation profile of a 59-gene panel was analyzed by targeted next generation sequencing (NGS) of the patients’ ctDNA samples. Differences in clinical factors between patients with and without ctDNA mutations were analyzed. In addition, we also explored gene mutation frequencies between GCB and non-GCB subtypes, and the relationship between gene mutation status, clinical factors, mean VAF (variant allele frequencies) and the patients’ overall survival (OS) and progression-free survival (PFS).ResultsctDNA mutations were detected in 64 (75.3%) patients of the training set and 67 (79.8%) patients of the validation set. The most commonly mutated genes in both sets were PCLO, PIM1, MYD88, TP53, KMT2D, CD79B, HIST1H1E and LRP1B, with mutation frequencies of &gt;10%. Patients with detectable ctDNA mutations trended to present advanced Ann Arbor stages (III-IV), elevated LDH (lactate dehydrogenase) levels, shorter OS and PFS, and a lower complete response (CR) rate to the R-CHOP regimen compared with DLBCL patients without ctDNA mutations. In addition, mean VAF (≥4.94%) and PCLO mutations were associated with poor OS and PFS.ConclusionWe investigated the ctDNA mutation landscape in Chinese patients with newly diagnosed DLBCL and found that ctDNA could reflect tumor burden and patients with detectable ctDNA mutations trended to have shorter OS and PFS and a lower CR rate.