bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wenyang-Huayin, a Chinese Medicine formulation, inhibits inflammation in OVA-Induced asthma rats
Authors: Yan Peizheng , Zhang Qingxiang , Qingjun Zhu , Chang Xing , Qingyan Meng , Liu Yan 
Published: January 2022

Abstract
Background and ObjectivesAsthma is a severe public health issue since it causes a progressive decline of pulmonary function and a lot of unnecessary deaths. Traditional Chinese medicine has played a great role in the prevention and treatment of asthma, Wenyang-Huayin (WYHY) formulation is one of the useful prescriptions in clinical, which the pharmacological mechanism has not yet been revealed. In this study, we explored its anti-airway inflammation and pulmonary protection effects in the treatment of asthma induced by ovalbumin (OVA), to provide support for its deeply clinical applications.MethodsAsthma model with the syndrome of accumulation of cold fluid in the lung in chronic bronchitis (a common type of Traditional Chinese Medicine (TCM) syndrome) was induced in SPF male Wistar rats by sensitizing and challenging with OVA, followed by drink, body cold and fatigue stimulation. WYHY was orally administered at 9.82142857 g·(kg·d)−1 body weight for 21 days, Rapamycin and the other two traditional Chinese medicines (Xiaoqinglong decoction and Astragalus granules) were used as positive controls. After intervention, the pulmonary function was measured by AniRes 2005 Animal pulmonary function Analysis system, the pathological features of pulmonary alveolus and bronchus were observed after Hematoxylin-Eosin (H&E) staining, and serum interleukin-13 (IL-13), transforming growth factor -β1 (TGF-β1), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) levels were determined by enzyme linked immunosorbent assay (ELISA) assay.ResultsThe model rats showed heavy signs of airway inflammation and remodeling like chronic asthma, evidenced by the damaged pulmonary alveolus structure, increased inflammatory cell infiltration, declined pulmonary function, and abnormal changes of cytokines. All treatment methods could slow down the damage caused by molding factors, and WYHY might have an advantage in pulmonary protection effects than the others.ConcludeWYHY has a good effect on anti-airway inflammation and protecting pulmonary function in the treatment of OVA-Induced asthma rats, and its mechanism is worth of in-depth study.
Association of Body Image and Body Mass Index with psychological outcomes in obese patients.
Authors: Campedelli Virginia , Ciacchella Chiara , Veneziani Giorgio , Meniconzi Irene , Paone Emanuela , Silecchia Gianfranco , Lai Carlo 
Published: January 2022

Abstract
PurposeThe purpose of this study was to test whether higher dissatisfaction with one's own body image, majorly than the body mass index (BMI), may be associated with higher levels of psychopathological aspects, hopelessness feelings, and psychophysical health. MethodsFifty-nine patients undergoing bariatric surgery filled out the Symptom Checklist-90-Revised, the Body Uneasiness Test, the 12-item Short Form Survey, the Beck Inventory Scale II, and the Beck Hopelessness Scale. Correlations and multiple regressions between measures were performed.ResultsDissatisfaction with the perception of one's own body image was strongly correlated with a worse psychophysiological health. On the contrary, BMI showed no significant correlation with the previous variables. Furthermore, the perception of one's own body image significantly predicted the state of psychological health.ConclusionThe findings of the present study showed a more relevant role of body image compared to the BMI in the association with psychological outcomes suggesting the importance to consider body image in the assessment and treatment of obese patients. Level of evidence﻿level II, evidence obtained from well-designed controlled trials without randomization.
Development of smart cold forging die life cycle management system based on real-time forging load monitoring
Authors: Seo Young Ho 
Published: January 2022

Abstract
Cold forging dies are manufactured through the shrink fit process to withstand high pressure loads, but fatigue failure eventually occurs due to repeated compressive stresses. The life cycle until fatigue failure was defined as the limit life, and attempts were made to predict the die life based on finite element method (FEM). However, accurate prediction was impossible owing to uncontrollable environmental variables. Consequently, it is impossible to clearly determine the die replacement cycle, resulting in negative consequences such as poor quality, production delay, and cost increase. Various environmental factors affecting the prediction of die life cycle result in the increase or decrease of the forming load, which is an important variable that determines the die life cycle. In this study, a system for monitoring load data generated from forging facilities was developed based on a piezo sensor. In addition, the die life cycle was more accurately predicted by using the forming load data measured in real time, and a die life management system that can determine the die replacement cycle was applied to the automobile steering parts production line.
Neuroendocrine Neoplasms of Breast:A Rare Breast Tumor Worthy of Attention
Authors: Zhao Yan , Zhu Qing , Fan Shuyue , Nan Wenhui , Zhang Luyao , Zhu Jie , Du Wenqiang , Jin Xin 
Published: January 2022

Abstract
Background: Neuroendocrine neoplasms of breast(NENB) is a rare and underrecognized subtype of breast neoplasms.The clinical significance, prognostic risk factors and optimal treatment modalities are limited. This study was focused on clinical and pathological features of 27 NENB cases to improve the understanding of these diseases and to further investigate the behavior of these neoplasms and to provide more factual evidence.Methods: We retrospectively analyzed the clinicopathological features and follow-up data of 27 patients diagnosed with NENB at the First Affiliated Hospital of Bengbu Medical College between February 2003 and February 2015.Results: The proportion of NENB from all invasive breast carcinomas(BC) in our hospital was 0.24% (27/11352). The expression of specific immunohistochemical markers was different: 48.1% cases showed the expression of chromogranin A (CgA)(13/27), CD56 was positive in 77.8%cases (21/27), the positive rate of INSM1 and synaptophysin (Syn) were 85.2%（23/27）and 100.0% (27/27). NENB occurred in older patients (median age,64 ).11cases (40.7%) were well-differentiated NETs and 16 cases (59.3%) were poorly differentiated NEC. In NETs, The positive rate of ER was 10/11 (90.9%) , while in NECs, The positive rate of ER was 9/16(56.3%) , On the basis of immunophenotypes, most of NENBs were of the luminal molecular subtype ,6 cases were luminal A and 15cases were luminal B ,6 cases were triple negative breast cancer(TNBC) and had no HER-2 overexpression subtypes. Conclusions: NENB more likely occures in elderly patients.Well-differentiated NETs are more often positive for hormone receptors than poorly differentiated NEC. NENBs are almost negative for HER-2. The combination of INSM1 is an effective supplement and improvement for traditional neuroendocrine markers.
Characterization of the Propagation Route of Light Passing Through Convex Lens
Authors: Mao Jiafa , Sheng Weiguo , Hu Yahong , Mao Kejie , Gao Hua , Liang Ronghua 
Published: January 2022

Abstract

Existing optical theory states that the light directed to the optical center of the convex lens will travel in a straight line. Does the theory hold? If this is true, then why the images formed by the camera lens tends to be distorted? To answer the question, this paper studied the propagation mode of light passing through convex lens. Specifically, assuming the propagation medium on both sides of convex lens is homogeneous, we propose an angular affine transformation (AAT) theory. Based on the proposed theory, we first derive the refractive index of convex lens as well as the method of calculating the normal direction of each point within the radius of convex lens radius and then derive the refraction direction of each point within the radius of convex lens, thus completely characterizing the path diagram of light directed to the optical center. The correctness of the proposed theory has been verified using two sets of experiments: characterization of the route of light passing through the convex lens as well as camera imaging experiment. From the results, it can be concluded that the light directed to the optical center of convex lens does not travel in a straight line, but in a refraction line.
Tool-Path Planning Method For Kinematics Optimization of Blade Machining On Five-Axis Machine Tool
Authors: Lu Zhongyang , Yang Xu , Zhao Ji 
Published: January 2022

Abstract
Planning tool-paths on free-form surfaces is a widely discussed issue. However, traditional methods of generating paths capable of meeting all the requirements of blade machining remain challenging. In this study, a new iso-parametric path-planning strategy based on a novel parameterization method combined with the conformal transformation theory was proposed. The proposed method could adapt to the curvature characteristics of the blade surface, improving the kinematic performance of the machining process, reducing multi-axis coordinated motion control complexity, and improving machining quality. The proposed method was then compared with three traditional methods. The influence of the tool-path on the kinematic performance of the machine tool was quantitatively examined based on the kinematics models of two different machine tools. A large cutting depth milling experiment was conducted to verify that kinematics optimization could improve machining quality. The proposed method provides a more reasonable path-planning approach for blade machining on a five-axis machine tool, which is of great significance in reducing the cost of blade machining and the risks of blade failure. Moreover, it is of great significance for the large-scale automated production of blades.
Baseline composition and microbial quality assessment of raw milk from endemic small ruminants and Maghrebi camels in the oasis area of Tunisia
Authors: Khaldi Zahran , Nafti Mounir , Jilani Mohamed Tabarek 
Published: January 2022

Abstract
Characteristics and quality aspects of milk from native ovine queue fine de l’Ouest (QFO) and the local goat population were investigated and compared with those of the local Maghrebi camel. A total of 378 individual milk samples were collected from lactating animals reared in the continental oasis region of Tunisia. Samples were analyzed for physical parameters (pH, density, and acidity), chemical composition (dry matter, fat, protein, lactose, casein, ash, and casein-protein ratio), mineral concentrations (Ca, P, Na, and K) and microbiological features (total mesophilic aerobic bacteria (TMAB), total coliform count (TCC), lactic acid bacteria (LAB), sulphite-reducing Clostridium (CSR), yeast and molds (Y/M), Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and Salmonella) according to standard methods. The results obtained for milk characteristics revealed noticeable disparities between the three species. The mean values of pH, density, and acidity in milk collected from sheep appeared higher than those in milk collected from goat species. Compared to the camel populations, sheep species produced milk with similar pH but higher density and acidity. Between camel and goat species, pH and acidity were higher in Negga, while the density was similar. For milk composition, the results showed a remarkable variation among all studied species and an obvious superiority of the ovine species over the caprine and camel populations in all the chemical contents being studied, except for the casein-protein ratio, which is in favor of goat species. The milk of QFO sheep, the richest in casein and protein, was expressed with significantly higher levels of calcium and phosphorus than goat and camel milk. Compared to small ruminants, milk from camels is the richest in Na and K. Additionally, more Ca is present in milk from camels than goats. Goat milk, the poorest type of milk in Ca and Na, contains on average more P than camel milk and more K than sheep's milk. The poor bacteriological quality was that of camel milk for all microbial counts. The microbial quality of goat milk was higher than that of ewe milk based on TMAB, TCC, and E. coli counts, while ovine milk was of better quality, referring to LAB, Y/M, and S. aureus values. No significant differences were found for Staphylococcus aureus and Escherichia coli between the examined species. The obtained results highlighted the complete absence of the two dangerous pathogens Salmonella and CSR in all investigated milk samples. The microbiological examination evidenced that the milk of small ruminant species complies with standard criteria required by Tunisian legislation on the hygiene of milk and dairy products. Regarding camel milk, the microbial analysis revealed poor quality that exceeds standard criteria.
Biodefense and Emergency Use Authorization: Different Originations, Purposes, and Evolutionary Paths of Institutions in the United States and South Korea
Authors: Kim HyunJung 
Published: January 2022

Abstract
Background:

Historical institutionalism (HI) determines that institutions have been transformed by a pattern of punctuated evolution due to exogenous shocks. Although scholars frequently emphasize the role of agency - endogenous factors – when it comes to institutional changes, but the HI analytic narratives still remain in the meso-level analysis in the context of structure and agency. This article provides domestic and policy-level accounts of where biodefense institutions of the United States and South Korea come from, seeing through emergency-use-authorization (EUA) policy, and how the EUA policies have evolved by employing the policy-learning concepts through the Event-related Policy Change Model.
Results:

By employing the Birkland’s model, this article complements the limitation of the meso-level analysis in addressing that the 2001 Amerithrax and the 2015 Middle East Respiratory Syndrome (MERS) outbreak rooted originations and purposes of the biodefense respectively. Since the crisis, a new post-crisis agenda in society contributed to establishing new domestic coalition, which begin to act as endogenous driving forces that institutionalize new biodefense institutions and even reinforce them through path dependent way when the institutions evolved. Therefore, EUA policy cores (Post-Exposure Prophylaxis (PEP) in the United States and Non-Pharmaceutical Intervention (NPI) in South Korea keep strengthened during the policy revisions.
Conclusions:

The United States and South Korea have different originations and purposes of biodefense, which are institutions evolving through self-reinforce dependent way based on the lessons learned from past crises. In sum, under the homeland security biodefense institution, the US EUA focuses on the development of specialized, unlicensed PEP in response to public health emergencies; on the other hand, under the disease containment-centric biodefense institution, the Korean EUA is specialized to conduct NPI missions in response to public health emergencies.
DNA Metabarcoding Reveals Cryptic Geographically-influenced Microbial Diversity After Anthropogenic Impact in Original Forest Soils on the Isolated Trindade Island, South Atlantic
Authors: Camara Paulo Saraiva , Bones Fabio , Lopes Fabyano , Oliveira Fabio , Barreto Cristine , Campos Larissa , Carvalho-Silva Micheline , Convey Peter , Rosa Luiz , Henriques Diego 
Published: January 2022

Abstract
Located 1,140 km from the South American coastline in the South Atlantic Ocean, and with an age of 4 million years, Trindade Island is the most recent volcanic component of Brazilian territory. Its vegetation was severely damaged by human influence in particular through the introduction of exotic grazing animals such as goats. However, since the complete eradication of goats and other feral animals in the late 1990s, the island’s vegetation has been recovering and even some endemic species that had been considered extinct have been rediscovered. In this study we set out to characterize the contemporary microbial diversity of Trindade Island forest soils using metabarcoding by High Throughput Sequencing (HTS). Sequences of representative of two domains (Bacteria and Archaea) and five kingdoms (Fungi, Metazoa, Protozoa, Chromista and Viridiplantae) were identified. Bacteria were represented by 20 phyla and 116 taxa, while and Archaea by only one taxon. Fungi were represented by seven phyla and 250 taxa, Viridiplantae by five phyla and six taxa, Protozoa by five phyla and six taxa, Metazoa by three phyla and four taxa and Chromista by two phyla and two taxa. Even after the considerable anthropogenic impacts and devastation of the island’s natural forest, our sequence data revealed the presence of a rich, diverse and complex diversity of microorganisms, invertebrates and plants.
The Association Between Diabetes Coexisting With Low Levels of High-density Lipoprotein Cholesterol and Peritoneal Dialysis-related Peritonitis
Authors: Zhang Rui , Zhang Xing , Tang Xingming , Tang Liwen , Shang Sijia , Wang Xiaoyang , Wen Yueqiang , Feng Xiaoran , Zhou Qian , Su Ning , Huang Yajuan 
Published: January 2022

Abstract
BackgroundLow levels of high-density lipoprotein-cholesterol (HDL-C) and diabetes are common in patients undergoing peritoneal dialysis (PD). The aim of this study was to investigate the association between diabetes coexisting with a low level of HDL-C and the first episode of peritoneal dialysis-related peritonitis (PDRP) in patients with PD.MethodsWe retrospectively investigated patients with PD from January 1, 2003, to May 31, 2020 in four PD centers. Patients with PD were divided into four groups: no comorbidity, low HDL-C only, diabetes only, and diabetes plus low HDL-C. The clinical and laboratory baseline data of the four groups were collected and compared. The association between diabetes coexisting with low HDL-C levels and the first episode of PDRP was analysed by multivariate Cox regression analysis. ResultsA total of 1013 patients with PD were recorded in our study. The mean age was 49.94±14.32 years, and 597 (58.99%) were males. A total of 301 (29.7%) patients had their first episodes of PDRP, and low HDL-C levels existed with diabetes in 72 patients with PD. After adjusting for confounding factors, a low level of HDL-C coexisting with diabetes was significantly associated with the first episode of PDRP in our study (hazard ratio: 1.93, 95% CI: 1.03-3.61, p<0.05). The associations between HDL-C, diabetes and PDRP were consistent in the following subgroups: sex, age, pre-existing CVD (all P interaction > 0.05).ConclusionsLow levels of HDL-C alone or diabetes alone were not independent risk factors for PDRP. Patients with both diabetes and low HDL-C levels were at high risk for PDRP.
To Enhance the Quality of HCRS using Fuzzy-Genetic Approach
Authors: Banda Latha , Singh Karan , Arya Vikash , Gautam Devendra , Ahmadian Ali 
Published: January 2022

Abstract
Social media is recent generation of Recommender Systems (RS). Health Care Recommender System (HCRS) term used to analyse the medical data and then predict the disease of a patient with the help of various techniques used in RS. To ensure the quality and trustworthiness of medical data, machine learning algorithms are applied. Even though, there is a much gap between health care diagnosis and IT solutions. To evade this gap, the hybrid Fuzzy-genetic approach is used in HCRS. In this, Genetic algorithm is used for similarity computations with the help of mutation and crossover operators. Later fuzzy rules are generated for the data set with the additional personalized information of a user. Considering these approaches, the proposed model enhances the quality of recommendation in HCRS.
Ti(IV)-exchanged nano-ZIF-8 and nano-ZIF-67 for Enhanced Photocatalytic Oxidation of Hydroquinone
Authors: Mphuthi Lehlohonolo E. , Maseme Mametsi R. , Langner Ernie H.G. 
Published: January 2022

Abstract
The metal centres of nano-ZIF-8(Zn) and nano-ZIF-67(Co) were partially exchanged with titanium centres to form bimetallic nZIF-8(Zn/Ti) (52% Ti4+) and nZIF-67(Co/Ti) (38% Ti4+) respectively, for enhanced photocatalytic performance. A morphological and structural analysis by SEM, EDS-Mapping and PXRD showed that the particle size, distribution, and the structural integrity of the Sodalite frameworks of the parent ZIFs were retained during the exchange process to form the new bimetallic Ti-ZIFs. FTIR confirmed that no additional chemical bonds were formed during the process. XPS binding energies confirmed the preservation of the Zn(II), Co(II) and Ti(IV) oxidation states, as well as the Ti-content, consistent with ICP-OES and EDS measurements. The Ti-exchanged ZIFs showed higher activity during the photocatalytic oxidation of hydroquinone in comparison with their parent ZIFs. Their kinetic rates were nearly five times faster than those of the parent ZIFs, with the first-order rate constants k = 0.189 min-1 for nZIF-8(Zn/Ti) and k = 0.139 min-1 for nZIF-67(Co/Ti). These catalysts are efficient, stable, and reusable for three photocatalytic cycles without a significant loss of catalytic activity.
Urinary Tract Infection Caused By Bacterial Pathogens of The Respiratory Tract In Children
Authors: Takahashi Yoko , Funaki Takanori , Ishiguro Akira , Miyairi Isao 
Published: January 2022

Abstract
Urinary tract infection (UTI) caused by bacterial pathogens of the respiratory tract such as Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis is rare and little is known about their characteristics and potential host risk factors. We conducted a retrospective descriptive study on pediatric UTI due to S. pneumoniae, Haemophilus spp., or M. catarrhalis at a tertiary-care pediatric hospital. Pediatric patients with diagnosed UTI between 2002 and 2020 were included. Patient demographics, laboratory data, and microbiological findings were extracted from their electronic medical records and the infectious disease surveillance system. Among 46,332 urine samples, 76 bacteriuria (0.16%) and 22 UTI (0.05%) events due to the targeted species were identified (S. pneumoniae [n=7] and Haemophilus spp. [n=15]). Of the patients, 17 (85%) had underlying urinary tract abnormalities and 13 (60%) had vesicocutaneous fistula. All the UTI episodes caused by S. pneumoniae and Haemophilus spp. occurred after cystostomy. All the patients had satisfactory clinical outcomes.Conclusion: Although S. pneumoniae and Haemophilus spp. are rare causes of UTI in children, they could be the true causative bacteria of UTI even when detected in urine specimens, particularly in the patients with urinary tract abnormalities and vesicocutaneous fistula.