bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nurse home visiting to improve child and maternal outcomes: 5-year follow-up of an Australian randomised controlled trial
Authors: Goldfeld Sharon , Bryson Hannah , Mensah Fiona , Price Anna , Gold Lisa , Orsini Francesca , Kenny Bridget , Perlen Susan , Bohingamu Mudiyanselage Shalika , Dakin Penelope , Bruce Tracey , Harris Diana , Kemp Lynn 
Published: November 2022

Objectives
Nurse home visiting (NHV) is widely implemented to address inequities in child and maternal health. However, few studies have examined longer-term effectiveness or delivery within universal healthcare systems. We evaluated the benefits of an Australian NHV program (“right@home”) in promoting children’s language and learning, general and mental health, maternal mental health and wellbeing, parenting and family relationships, at child ages 4 and 5 years.

Setting and participants
Randomised controlled trial of NHV delivered via universal, child and family health services (the comparator). Pregnant women experiencing adversity (≥2 of 10 risk factors) were recruited from 10 antenatal clinics across 2 states (Victoria, Tasmania) in Australia.

Intervention
Mothers in the intervention arm were offered 25 nurse home visits (mean 23·2 home visits [SD 7·4, range 1–43] received) of 60–90 minutes, commencing antenatally and continuing until children’s second birthdays.

Primary and secondary outcomes measured
At 4 and 5 years, outcomes were assessed via parent interview and direct assessment of children’s language and learning (receptive and expressive language, phonological awareness, attention, and executive function). Outcomes were compared between intervention and usual care arms (intention to treat) using adjusted regression with robust estimation to account for nurse/site. Missing data were addressed using multiple imputation and inverse probability weighting.

Results
Of 722 women enrolled in the trial, 225 of 363 (62%) intervention and 201 of 359 (56%) usual care women provided data at 5 years. Estimated group differences showed an overall pattern favouring the intervention. Statistical evidence of benefits was found across child and maternal mental health and wellbeing, parenting and family relationships with effect sizes ranging 0·01–0·27.

Conclusion
An Australian NHV program promoted longer-term family functioning and wellbeing for women experiencing adversity. NHV can offer an important component of a proportionate universal system that delivers support and intervention relative to need.

Trial registration
2013–2016, registration ISRCTN89962120
Protocol for a winter sentinel surveillance program of notifiable respiratory viruses in Queensland
Authors: Ginige Shamila , Firman Elise , Li Yee Sum , Soonarane Yudish , Smoll Nicolas , May Fiona , Hunter Ian , Pery Brielle , Macfarlane Bonnie , Bladen Tracy , Allen Terresa , Lennon Melinda , Walker Jacina , Slinko Vicki , Stickley Mark , Khandaker Gulam , Anuradha Satyamurthy , Wattiaux Andre 
Published: November 2022

BackgroundWith the reduction in access to polymerase chain reaction (PCR) testing and changes in testing guidelines in Australia, a reduced number of people are seeking testing for coronavirus disease (COVID-19), limiting the opportunity to monitor disease transmission. Knowledge of community transmission of COVID-19 and other respiratory viruses is essential to better predict subsequent surges in cases during the pandemic to alert health services, protect vulnerable populations and enhance public health measures. We describe a methodology for a testing-based sentinel surveillance program to monitor disease in the community for early signal detection of SARS-CoV-2 and other respiratory viruses.Methods/designA longitudinal active testing-based sentinel surveillance program for respiratory viruses (including SARS-CoV-2, influenza A, influenza B and Respiratory Syncytial Virus) will be implemented in some regions of Queensland. Adults will be eligible for enrolment if they are part of specific community groups at increased risk of exposure and have not had a COVID-19 infection in the last 13 weeks. Recruitment via workplaces will occur in-person, via email and through online advertisement. Asymptomatic participants will be tested via PCR for SARS-CoV-2 infection by weekly self-collected nasal swabs. In addition, symptomatic participants will be asked to seek SARS-CoV-2 and additional respiratory virus PCR testing at nominated COVID-19 testing sites. SARS-CoV-2 and respiratory virus prevalence data will be analysed weekly and at the end of the study period.DiscussionOnce implemented, this surveillance program will determine the weekly prevalence of COVID-19 and other respiratory viruses in the broader community by testing a representative sample of adults, with an aim to detect early changes in the baseline positivity rate. This information is essential to define the epidemiology of SARS-CoV-2 in the community in near-real time to inform public health control measures and prepare health services and other stakeholders for a rise in service demand.
MiR-302d inhibits TGFB-induced EMT and promotes MET in primary human RPE cells
Authors: Hu Xiaonan , Binter Maximilian , Hufendiek Karsten , Tode Jan , Framme Carsten , Fuchs Heiko 
Published: November 2022

Purpose
Transforming growth factor-beta (TGFB)-mediated epithelial-mesenchymal transition (EMT) plays a crucial role in the pathogenesis of retinal fibrosis, which is one of the leading causes of impaired vision. Current approaches to treating retinal fibrosis focus, among other things, on inhibiting the TGFB signaling pathway. Transient expression of microRNAs (miRNAs) is one way to inhibit the TGFB pathway post-transcriptionally. Our previous study identified the miRNA miR-302d as a regulator of multiple TGFB-related genes in ARPE-19 cells. To further explore its effect on primary cells, the effect of miR-302d on TGFB-induced EMT in primary human retinal pigment epithelium (hRPE) was investigated in vitro.

Methods
hRPE cells were extracted from patients receiving enucleation. Transfection of hRPE cells with miR-302d was performed before or after TGFB1 stimulation. Live-cell imaging, immunocytochemistry staining, Western blot, and ELISA assays were utilized to identify the alterations of cellular morphology and EMT-related factors expressions in hRPE cells.

Results
hRPE cells underwent EMT by TGFB1 exposure. The transfection of miR-302d inhibited the transition with decreased production of mesenchymal markers and increased epithelial factors. Meanwhile, the phosphorylation of SMAD2 activated by TGFB1 was suppressed. Moreover, miR-302d expression promoted TGFB1-induced fibroblast-like hRPE cells to revert towards an epithelial stage. As confirmed by ELISA, miR-302d reduced TGFB receptor 2 (TGFBR2) and vascular endothelial growth factor A (VEGFA) levels 48 hours after transfection.

Conclusions
The protective effect of miR-302d might be a promising approach for ameliorating retinal fibrosis and neovascularization. MiR-302d suppresses TGFB-induced EMT in hRPE cells via downregulation of TGFBR2, even reversing the process. Furthermore, miR-302d reduces the constitutive secretion of VEGFA from hRPE cells.
Risk factors and survival in patients with COVID-19 in northeastern Brazil
Authors: Fernandes Ana Tereza , Rodrigues Eujessika K. , Araújo Eder R. , Formiga Magno F. , Horan Priscilla K. Sá , Ferreira Ana Beatriz Nunes de Sousa , Barbosa Humberto A. , Barbosa Paulo S. 
Published: November 2022

Background
Knowledge about the epidemiology and risk factors surrounding COVID-19 contributes to developing better health strategies to combat the disease.

Objective
This study aimed to establish a survival analysis and identify the risk factors for patients with COVID-19 in an upper middle-income city in Brazil.

Methods
A retrospective cohort study was conducted with 280 hospitalized patients with COVID-19. The eCOVID platform provided data to monitor COVID-19 cases and help the communication between professionals.

Results
Age ≥ 65 years was associated with decreased survival (54.8%), and females had a lower survival rate than males (p = 0.01). Regarding risk factors, urea concentration (p<0.001), hospital length of stay (p = 0.002), oxygen concentration (p = 0.005), and age (p = 0.02) were associated with death.

Conclusion
Age, hospital length of stay, high blood urea concentration, and low oxygen concentration were associated with death by COVID-19 in the studied population. These findings corroborate with studies conducted in research centers worldwide.
Factors Affecting Child Marriage in West Nusa Tenggara
Authors: Rofita Desi , Makmun Indriyani , Amilia Rizkia , Lestari Cahaya Indah , Sofiatun Sofiatun 
Published: November 2022

Background: Child marriage is a significant problem millions of girls face every year. During the period of 2015 – 2018, the increase and decrease in prevalence at the provincial level varied in magnitude. There are 11 provinces that experience marriage for the first time in less than 18 years. One of them is the Province of Nusa Tenggara by 15.48%. The purpose of this research is to observe the factors affecting the incidence of child marriage.Method: This is a quantitative research using secondary data from the Survey of Program Accountability and Performance (SKAP) in West Nusa Tenggara Province, Indonesia as many as 1,292 women of childbearing age. Independent variables included age, education level, occupation, and area of residence; while dependent variable referred to child marriage.Results: There was a significant relationship between age and 95% CI = 1.151-1.754 (p = 0.00), education level and 95% CI = 1.997-3.111, (p = 0.00), employment status and 95% CI = 0.564- 0.895, (p = 0.00), information exposure and 95% CI = 1.178-2.672, (p = 0.00), on the incidence of child marriage. Respondents not attending school had a 2.4 times risk of child marriage, while information exposure has a chance of child marriage, as indicated by a prevalence ratio of 1.7. The area of residence did not have a significant relationship with child marriage with 95% CI = 0.821-1.305, (p = 0.76). The results showed that there was a significant relationship between age, education level, employment status, and information exposure to child marriage. The area of residence did not have a significant relationship with child marriage. Therefore, it is necessary to increase the knowledge of women of childbearing age by providing education such as counseling about the impacts of child marriage.
A real-time algorithm for continuous navigation in intelligent transportation systems using LiDAR-Gyroscope-Odometer integration
Authors: Hassan Tarek , Fath-Allah Tamer , Elhabiby Mohamed , ElDin Awad Alaa , El-Tokhey Mohamed 
Published: November 2022

AbstractReal-time positioning in suburban and urban environments has been a challenging task for many Intelligent Transportation Systems (ITS) applications. In these environments, positioning using Global Navigation Satellite Systems (GNSS) cannot provide continuous solutions due to the blockage of signals in harsh scenarios. Consequently, it is intrinsic to have an independent positioning system capable of providing accurate and reliable positional solutions over GNSS outages. This study exploits the integration of Light Detection and Ranging (LiDAR), gyroscope, and odometer sensors, and a novel real-time algorithm is proposed for this integration. Real field data, collected by a moving land vehicle, is used to test the presented algorithm. Three simulated GNSS outages are introduced in the trajectory such that each outage lasts for five minutes. The results show that using the proposed algorithm can achieve a promising navigation performance in urban environments. In addition, it is shown that the denser environments, that existed over the second and third outages, can provide better positioning accuracies as more features are extracted. The horizontal errors over the first outage, with less density of surroundings, reached 7.74 m (0.43%) error with a mean value of 3.15 m. Moreover, the horizontal errors in the denser environments over the second and third outages reached 4.97 m (0.28%) and 3.99 m (0.23%), with mean values of 2.25 m and 1.89 m, respectively.
Empirical laser measured with optical coherent quadrate amplitude modulation receiver for upgrading fiber optic systems
Authors: Khodaei Amin , Altahan Baraa Riyadh , Manasavenna Thaticharla , Priya Putcha Poorna , Krishna Merugumalli Rama , Ahammad Shaik Hasane , Amzad Hossain Md. , Zaki Rashed Ahmed Nabih , Zidan Walid Fahim 
Published: November 2022

Abstract
The work clarified the empirical laser measured with optical coherent quadrate amplitude modulation receiver for upgrading fiber optic systems. Peak signal amplitude and output power spectrum are measured after light receivers under the control of extinction modulator ratio, radio frequency switching voltage and switching bias voltage. The better the fiber optic system performance can be achieved with the higher values of extinction ratio, both switching radio frequency and bias voltages based LiNb modulators.
UOWC performance based on GMSK modulation
Authors: Hameed Samir M. 
Published: November 2022

Abstract
This paper studies and investigates the performance of Gaussian minimum shift keying (GMSK) for underwater optical wireless communication (UOWC). Various scatterings may result in inter-symbol interference (ISI) and degrade system error performance in UWOC links. Bit-error rate (BER) is evaluated using different water environment models such as clear seawater, coastal, and harbor for a 20 m link range. Simulation results indicate the BER performance is degraded due to the temporal dispersion of impulse response for high data rates in turbid water. In addition, the bandwidth-symbol time product (BT) is an essential parameter in GMSK, affecting BER performance and power efficiency. Therefore, BT must be chosen with a value that balances BER and power efficiency. The results show that GMSK with BT = 0.5 is a good choice that satisfies BER = 10−5 for SNR = 10 dB with an efficient power spectrum due to constant envelope and low out-of-band radiation.
Thiamine status during treatment of diabetic ketoacidosis in children – tertiary care centre experience
Authors: Abdelaziz Tarek A. , Atfy Mervat , Elalawi Saffaa M. , Baz Eman Gamal 
Published: November 2022

Abstract

Objectives
There is a lack of information regarding thiamine status in children with diabetic ketoacidosis (DKA). This study was designed to assess the thiamine status upon admission and 24 h after treatment initiation of DKA, whether newly diagnosed children or with established T1DM diagnosis, who presented with DKA.

Methods
We enrolled 90 children (mean age, 9.8 ± 2.6 years; 58 females and 32 males) with type 1 diabetes mellitus (T1DM), whether newly diagnosed or with an established T1DM diagnosis (from 1 to 5.2 years ago), who presented with DKA. We observed the initial Glasgow Coma Scale (GCS) and recovery time. The whole blood thiamine diphosphate levels were measured upon admission (baseline point) and 24 h after initiation of the DKA treatment (second-time point).

Results
The mean blood thiamine levels at the second-time point (90.11 ± 15.76 nmol/L) significantly decreased compared with their levels at baseline (108.8 ± 17.6 nmol/L) (p<0.001). We compared thiamine levels with the initial GCS, patient’s age, and recovery time. Thiamine levels at the second-time point were positively correlated with baseline thiamine levels (r=0.86, p=0.0001) and the initial GCS (r=0.68, p=0.001) but were negatively correlated with patient’s age (r=−0.61, p=0.001) and recovery time (r=−0.724, p=0.001). Based on multiple regression analysis, thiamine levels at the second-time point were directly related to the initial GCS and inversely related to the patient’s age.

Conclusions
The current study indicates that blood thiamine diphosphate levels significantly decreased after 24 h of DKA treatment initiation compared to pre-treatment levels. After 24 h of treatment initiation, blood thiamine levels are directly related to the initial GCS and inversely related to the patient’s age.
Comparison of phase rectified signal averaging and short term variation in predicting perinatal outcome in early onset fetal growth restriction
Authors: Bruin Claartje M. , Lobmaier Silvia M. , Ganzevoort Wessel , Müller Alexander , Wolf Hans 
Published: November 2022

Abstract

Objectives
To compare short term variation (STV) and phase rectified signal averaging (PRSA) and their association with fetal outcome in early onset fetal growth restriction (FGR).

Methods
Data were used from a retrospective cohort study of women who were admitted for FGR and/or pre-eclampsia and who were delivered by pre-labor Cesarean section or had a fetal death before 32 weeks’ gestation. Computerized cardiotocography (cCTG) registrations of the 5 days before delivery or fetal death were used for calculation of STV and PRSA. PRSA was expressed as the average acceleration capacity (AAC) and average deceleration capacity (ADC). FHR decelerations were classified visually as absent, 1–2 per hour or recurrent. Abnormality of STV and of PRSA was either analyzed as a single parameter or in combination with recurrent decelerations. Endpoints were defined as composite adverse condition at birth consisting of fetal death, low Apgar score, low umbilical pH, the need for resuscitation after birth and as major neonatal morbidity or neonatal death.

Results
Included were 367 pregnancies of which 20 resulted in fetal death. An abnormal cCTG with either recurrent decelerations and/or low STV or recurrent decelerations and/or low PRSA were similarly associated with composite adverse condition at birth (n=99), but neither with major neonatal morbidity.

Conclusions
PRSA and STV have similar efficacy for measuring fetal heart rate variation in early onset FGR. An increased risk of a composite adverse condition at birth is indicated by a low value of either parameter and/or the presence of recurrent decelerations.
Corrosion resistance of commercial glazes of floor tiles
Authors: Karataş Cengiz , Şimşek Veli 
Published: November 2022

Abstract
The main aim of this article was to develop new glaze receipts (NGRs) to build up the acid resistance (AR) of commercial glazes (CGs) used in floor tile production. The glaze is a vitrified material that melts the surface of the ceramic material. Improvements were made during and after the manufacture, based on the glaze samples of the CGs. NGRs were synthesized using different mineral compositions. AR, density, chemical, and physical properties of commercial and new synthesized glazes were determined using X-ray diffraction, scanning electron microscopy/energy-dispersive X-ray spectroscopy, Fourier transform infrared spectrometry, and water contact angle analysis methods. The AR of the obtained samples (standard and developed floor tiles) was examined by treating them with 3% HCl for 3 days. Results showed that synthesized glazes had higher AR than standard glazes (CGs). The NGRs also significantly improved the ceramic surface coating features of the new glazes.
Strategische Irrtümer, Fehler und Fehlannahmen der deutschen Energiepolitik seit 2002
Authors: Umbach Frank 
Published: November 2022

Kurzfassung
Deutschlands gescheiterte Russland-Politik der letzten beiden Jahrzehnte mit ihren kollektiven Fehlannahmen und Fehleinschätzungen ist eng verbunden mit seiner Energiepolitik seit 2002, insbesondere mit der Gasimportabhängigkeit von Russland. Der Faktor Versorgungssicherheit und die damit verbundenen geopolitischen Risiken wurden von den Bundesregierungen, aber auch den einschlägigen Ökonomen und Wirtschaftsjournalisten sowie der Wirtschaft weitgehend ausgeblendet oder marginalisiert. Die steigende Gasimportabhängigkeit war auch Folge des deutschen Doppelausstiegs aus der Kernenergie und der Kohle. Sowohl Deutschlands Russlandpolitik wie seine energiepolitischen Alleingänge haben in Brüssel und bei den Nachbarstaaten Deutschlands und in den USA erhebliches Misstrauen verursacht. In der Perzeption vieler Europäer hat Deutschland als größte und mächtigste Wirtschaftsmacht in Europa das Kernprinzip der politischen Solidarität wiederholt nicht beachtet und nicht vorgelebt. Aus diesen Fehlern muss Deutschland nun die richtigen Schlussfolgerungen für seine „Zeitenwende“ ziehen, um weitere kostspielige Fehlentscheidungen und außenpolitische Kollateralschäden bei seiner künftigen Energiewende zu vermeiden.
Initial data analysis: A new technology not yet ready to use
Authors: Vach Werner 
Published: November 2022

Abstract
In the ongoing discussion on improving quality and reproducibility of research, the data pipeline had been identified as one crucial element. Everything happening with the data already prior to the final analysis may have a highly relevant impact on the final analysis itself and its interpretation. Consequently, there is an increased focus on these processes. Sound practices for initial data analyses (IDA) have been described and the rigorous use of IDA has been advocated. However, IDA can only have a positive impact on research quality if findings from a systematic data screening lead to reasonable changes in the final analysis or its interpretation. In this communication some general challenges in finding adequate responses to findings from data screening are identified. They reflect a lack of knowledge and consensus. Consequently, rigorous future use of IDA can only be advocated if guidance for responding to data screening findings is further developed. With the knowledge present today, IDA may do more harm than good.
Bīt mēseri at Aššur
Authors: Schwemer Daniel 
Published: November 2022

Abstract
A 191, a Neo-Assyrian tablet from the Haus des Beschwörungspriesters in Aššur, preserves instructions for the performance of an apotropaic ritual called Bīt mēseri (“house of enclosure”). The tablet, which is edited here for the first time, offers a version of the ceremony that is markedly different from the standard Bīt mēseri ritual known from other first-millennium sources found at Nineveh, Aššur, and various Babylonian sites. Whereas the core rites with their apotropaic images (figurines and paintings) are far less complex than their counterparts in the standard ritual, the ceremony attested on A 191 also includes elements that are absent in other Bīt mēseri sources. These elements include a Pazuzu rite, ointments, and the burning of incense, all of which are known from other āšipūtu (exorcistic) text series, such as Muššuʾu, Qutāru, the Zi-pà Compendium, and the Pazuzu Compendium.