bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desenvolvimento, Satisfação e Usabilidade de plataforma móvel para monitoramento da saúde mental de estudantes universitários
Authors: Ferreira Lucas Fortaleza de Aquino , Benevides Ana Maria Luna Neri , Rabelo Jayanne Antonia Ferreira , Medeiros Melissa Soares , Barros Filho Edgar Marçal de , Sanders Lia Lira Olivier , Peixoto Raquel Autran Coelho 
Published: January 2022

Objetivo: Este estudo objetivou desenvolver e avaliar usabilidade e satisfação um aplicativo para smartphone (App) que facilite a triagem e o acompanhamento de sintomas emocionais e fatores associados à saúde mental de universitários. Metodologia: Trata-se de um estudo transversal, com aplicação de questionários por Google Forms® entre alunos do curso de medicina de um Centro Universitário, entre julho de 2020 a novembro 2021. Após uso do App desenvolvido por uma equipe multiprofissional, os alunos responderam a dados clínico-demográficos, uma versão em português da escala de usabilidade do sistema (SUS-System Usability Scale) e um questionário sobre a satisfação com o aplicativo. Resultados: O App, disponível para plataformas Android e iOS, continha 32 questões autoaplicáveis de escalas validadas no Brasil sobre depressão, ansiedade, estresse, insônia e sedentarismo (Depression, Anxiety and Stress Scale -DASS-21, Insomnia Severity Index -ISI e International Physical Activity Questionnaire -IPAQ). Ao término das respostas, forneciam-se interpretações baseados nas pontuações obtidas, incluindo orientações sobre quando buscar ajuda profissional e conteúdos educativos. 31 alunos responderam aos questionários de usabilidade e satisfação após testarem o App. A idade média foi de 25,2 anos. 16,1% tinham diagnóstico prévio ou atual de transtorno depressivo, e 41,9% de ansiedade. O valor de escore médio da escala SUS foi de 84. Todos os alunos ficaram satisfeitos com o aplicativo, e o recomendariam a outro colega. Conclusão: Houve boa usabilidade e satisfação, sugerindo potencial de triagem e monitoramento do App de transtornos mentais entre estudantes de medicina.
Fatores influenciadores para adesão à vacina contra o papilomavírus humano: uma revisão integrativa
Authors: Romeu Wédila Renata Oliveira Grangeiro , Gomes Emiliana Bezerra , Sampaio Larissa Alves , Carneiro Yasmin Ventura Andrade , Beltrão Izabel Cristina Santiago Lemos de , Cruz Rachel de Sá Barreto Luna Callou , Oliveira Dayanne Rakelly de 
Published: January 2022

Objetivo: Analisar os fatores que influenciam à adesão à vacina contra o Papilomavírus Humano em meninos escolares. Metodologia: Revisão integrativa da literatura (RIL), ocorreu no período fevereiro a abril de 2018. A revisão integrativa foi realizada na Biblioteca Virtual em Saúde (BVS), a qual inclui a Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), IBECS, Medical Literature Analysis and Retrieval System Online (MEDLINE), Biblioteca Cochrane e a Scientific Electronic Library Online (SciELO). Após a leitura e aplicação dos critérios foram elegidos 22 artigos para análise na íntegra. Resultados: Quanto aos fatores influenciadores à adesão à vacina contra o HPV, estes foram divididos em dois grupos: fatores positivos e fatores negativos. Dentro de cada grupo, foram eleitos os aspectos mais abordados nos estudos, possibilitando agrupá-los para uma melhor compreensão, elencados em três grupos: Conhecimentos, atitudes e percepções dos pais/responsáveis; Fatores socioculturais e educação em saúde. Conclusão: Os estudos trazem diversos influenciadores no processo de tomada de decisão, tanto positivos quanto negativos em relação à aceitação da vacina. Os fatores aqui descritos são de grande relevância, pois através do conhecimento destes, profissionais de saúde poderão estabelecer um papel ativo na elaboração de estratégias que visem uma maior adesão à campanha de vacinação contra o Papilomavírus Humano (HPV).
Institucionalização da assistência farmacêutica no município de Augusto Corrêa, Pará
Authors: Ferreira Tassio Luís Silva , Silva Taize Catarina Monteiro , Costa Bruno Wesley Bezerra , Lima Gustavo Campos de , Castanho Kelly Crisane de Oliveira Castro , Soler Orenzio 
Published: January 2022

Objetivo: Investigar a institucionalização da assistência farmacêutica no município de Augusto Corrêa, Pará. Método: Pesquisa exploratória, retrospectiva e descritiva, realizada em 2021. Para obtenção de indicadores socioeconômicos, demográficos, epidemiológicos, serviços de saúde, despesas totais em saúde, utilizou-se dados do Cadastro de Estabelecimentos de Saúde do Departamento de Informática do SUS, do Instituto Brasileiro de Geografia e Estatística, do Instituto de Pesquisa Econômica Aplicada e do Sistema de Informação de Atenção Básica. Para as informações sobre práticas de governança, planejamento, gestão, componentes técnicos-gerenciais e técnicos-assistenciais da Assistência Farmacêutica, utilizou-se formulários estruturados, aplicados por meio da ferramenta Survey Monkey®, via Internet®, à coordenação da Assistência Farmacêutica da Secretaria Municipal de Saúde do município de Augusto Corrêa, Pará. Resultados: Augusto Corrêa tem uma População Estimada de 46.937 habitantes em 2021 e Densidade Demográfica de 37,10 habitantes/km² em 2010. Área Territorial de 1.099,619 km² em 2020. Faz parte do Bioma Amazônia, da Mesorregião Nordeste Paraense, Microrregião Bragantina. 0,520 de Índice de Desenvolvimento Humano Municipal em 2010. 0,4145 de Índice de Gini da Renda Domiciliar Percapta em 2010. Não cumpre integralmente as práticas de governança no nível da coordenação técnica de assistência farmacêutica; em especial, pessoal e competências, princípios e comportamentos, liderança organizacional, relacionamento com partes interessadas, estratégia organizacional, alinhamento transorganizacional, estrutura de governança, gestão de risco e controle interno, auditoria interna, accountability e transparência. Também, não cumpri todos os componentes para a Gestão Técnica da Assistência Farmacêutica e a Gestão Clínica do Medicamento. Conclusão: Constatou-se o não cumprimento integral dos componentes da gestão técnica da assistência farmacêutica e da gestão clínica do medicamento; assim como, as práticas de governança no nível da coordenação técnica de assistência farmacêutica precisam ser aprimoradas; em especial, pessoal e competências, princípios e comportamentos, liderança organizacional, relacionamento com partes interessadas, estratégia organizacional, alinhamento transorganizacional, estrutura de governança, gestão de risco e controle interno, auditoria interna, accountability e transparência.
Potencial de utilização de resíduos da cultura de soja tratados com água e hidróxido de sódio para produção de painéis aglomerados
Authors: Borges Ianca Oliveira , Miranda Eduardo Hélio de Novais , Brito Flávia Maria Silva , Altafin Nayara Cristina da Silva , Mendes Lourival Marin , Guimarães Júnior Jose Benedito 
Published: January 2022

O Brasil é um dos maiores produtores de soja e, consequentemente, gera uma grande quantidade de resíduos provenientes dessa cultura, os quais poderiam ser aproveitados na confecção de aglomerados. Este trabalho objetivou analisar as características físico-mecânicas de painéis aglomerados, produzidos com partículas de resíduos de soja e eucalipto, tratadas em água fria e hidróxido de sódio. Adotou-se uma proporção de 50:50 de partículas de eucalipto e casquilho de soja. A densidade nominal dos painéis foi 0,60 g/cm³. Foi utilizado adesivo uréia-formaldeído com teor de sólidos de 12 %. Foram adotados três tratamentos: partículas tratadas com água fria e partículas tratadas com NaOH (com concentração de 1%, além de um tratamento com partículas controle. Os componentes químicos dos materiais lignocelulósicos foram quantificados para as três situações. Os parâmetros do ciclo de prensagem foram: 4 MPa (pressão), 150 °C (temperatura), durante 8 min. Foram observadas reduções nos teores de extrativos totais, após os tratamentos. Em relação às propriedades físicas, os tratamentos aplicados nas partículas não demonstraram eficiência, pois não trouxeram melhorias para a estabilidade dimensional dos painéis e nenhum dos tratamentos atingiram ao valor mínimo especificado pela norma utilizada. Para as propriedades mecânicas, os painéis produzidos com partículas tratadas com água atenderam as exigências para o MOE. Para as propriedades de tração perpendicular e dureza Janka, todos os painéis alcançaram os valores especificados pela NBR 14810 (2013). As outras propriedades testadas (MOR, APS e APT) não atenderam a norma. Os tratamentos aplicados nas partículas de soja e eucalipto não demonstraram eficiência para as propriedades físicas, porém algumas propriedades mecânicas atenderam aos requisitos mínimos da NBR 14810 (2013) para painéis não estruturais para uso interno em ambiente seco (Tipo P2).
ELECTROREDUCTION OF DITUNGSTATE AND CARBONATE ANIONS IN CHLORIDE MELT
Authors: Novoselova Inessa , Kuleshov Serhii , Omel’chuk Anatoliy , Bykov Valerii , Fesenko Olena 
Published: January 2022

Electrocatalysis is one of the actively developing fields of application of tungsten carbides. For the synthesis of catalytically active carbides (materials with a large specific surface area, small particle size and structural defects) a large number of different technologies are being developed in the world. The method of high-temperature electrochemical synthesis is promising one. For its successful realization, it is necessary to study in detail the electrochemical behavior of each carbide component (tungsten and carbon) and the features of their partial and joint discharge. The aim of this paper is a voltammetric study of the partial and joint electroreduction of Na2W2O7 and Li2CO3 in molten NaCl–KCl electrolyte under CO2 pressure at a temperature of 750 °C.
As a result of research, it was found that in the system Na,K|Cl–Na2W2O7–Li2CO3–CO2 joint reduction of tungsten carbide synthesis components occurs from lithium complexes of tungstate (LixWO4)2-x and carbonate- (LixCO3)2-x anions at potentials -1.65 – -1.8 V. Introduction of СО2 into the system (creation of its excess pressure in the cell) is necessary for the binding of oxide anions O2-, released during the discharge of anionic complexes, into a carbonate complex. The released oxide anion in the near-electrode layer inhibits the cathodic process. Also, a necessary condition for the sustainability production of tungsten monocarbide WC is the presence of free carbon, which is formed during the decomposition of CO2.
Nanosized composites of tungsten carbides with free carbon WC/C (5 wt%) were obtained by potentiostatic electrolysis at a potential of -1.8 V as a cathode product. The properties of the obtained compounds were analyzed by XRD, SEM, BET, and Raman spectroscopy. Tungsten carbide has a particle size of ~ 10 nm and consists of hollow spherical structures. The synthesized composite is mesoporous material with a specific surface area of ~ 140 m2/g.
The properties of the synthesized compo­site, namely: structural defects, the presence of free carbon, spherical morphology, nanometer size and high specific surface area, make it possible to use it as an effective electrocatalyst, for example, in the reaction of hydrogen evolution in acidic aqueous solutions.
A Green Route for High-Yield Production of Tetramethylpyrazine From Non-Food Raw Materials
Authors: Li Jing , Lu Jian , Ma Zhilin , Li Jianxiu , Chen Xianrui , Diao Mengxue , Xie Nengzhong 
Published: January 2022

2,3,5,6-Tetramethylpyrazine (TMP) is an active pharmaceutical ingredient originally isolated from Ligusticum wallichii for curing cardiovascular and cerebrovascular diseases and is widely used as a popular flavoring additive in the food industry. Hence, there is a great interest in developing new strategies to produce this high-value compound in an ecological and economical way. Herein, a cost-competitive combinational approach was proposed to accomplish green and high-efficiency production of TMP. First, microbial cell factories were constructed to produce acetoin (3-hydroxy-2-butanone, AC), an endogenous precursor of TMP, by introducing a biosynthesis pathway coupled with an intracellular NAD+ regeneration system to the wild-type Escherichia coli. To further improve the production of (R)-AC, the metabolic pathways of by-products were impaired or blocked stepwise by gene manipulation, resulting in 40.84 g/L (R)-AC with a high optical purity of 99.42% in shake flasks. Thereafter, an optimal strain designated GXASR11 was used to convert the hydrolysates of inexpensive feedstocks into (R)-AC and achieved a titer of 86.04 g/L within 48 h in a 5-L fermenter under optimized fermentation conditions. To the best of our knowledge, this is the highest (R)-AC production with high optical purity (≥98%) produced from non-food raw materials using recombinant E. coli. The supernatant of fermentation broth was mixed with diammonium phosphate (DAP) to make a total volume of 20 ml and transferred to a high-pressure microreactor. Finally, 56.72 g/L TMP was obtained in 3 h via the condensation reaction with a high conversion rate (85.30%) under optimal reaction conditions. These results demonstrated a green and sustainable approach to efficiently produce high-valued TMP, which realized value addition of low-cost renewables.
Metabolic Engineering of Escherichia coli for Ectoine Production With a Fermentation Strategy of Supplementing the Amino Donor
Authors: Zhang Hao , Liang Zhong , Zhao Ming , Ma Yanqin , Luo Zhengshan , Li Sha , Xu Hong 
Published: January 2022

Ectoine, an osmotic pressure-compensated solute, is used in the food, agriculture, medicine, and cosmetics industries due to its ability to protect macromolecules. In this study, an ectoine-producing variant of Escherichia coli, ET08, was genetically constructed by introducing the ectABC gene cluster and eliminating metabolic pathways involving lysine and pyruvate. Medium optimization enhanced ectoine production from 1.87 to 10.2 g/L. Analysis of the transcriptional levels revealed that supplementation with ammonium sulfate enhanced the metabolic flux towards the biosynthesis of ectoine. Furthermore, by optimizing the copy number of ectA, ectB, and ectC, the recombinant E. coli ET11 (ectA:ectB:ectC = 1:2:1) produced 12.9 g/L ectoine in the shake flask and 53.2 g/L ectoine in a fed-batch fermenter, representing the highest ectoine titer produced by E. coli, which has great industrial prospects.
Recent Progress in Luminescent Cu(I) Halide Complexes: A Mini-Review
Authors: Mensah Abraham , Shao Juan-Juan , Ni Jian-Ling , Li Guang-Jun , Wang Fang-Ming , Chen Li-Zhuang 
Published: January 2022

Copper(I) halide complexes are well sought-after materials due to their rich structural diversities and photophysical properties. Profoundly, there is a direct relationship between each structural variation and luminescence of these complexes, for a purported use. In this review, recent publications within the last 2 years about copper(I) halide complexes, centering on their structural dimensionalities with derivatives of nitrogen, phosphorus, and sulfur ligands, have been considered alongside their effects on luminescence.
Epitaxial Growth of Bi2Se3 Infrared Transparent Conductive Film and Heterojunction Diode by Molecular Beam Epitaxy
Authors: Chuai Ya-Hui , Zhu Chao , Yue Dan , Bai Yu 
Published: January 2022

Epitaxial n-type infrared transparent conductive Bi2Se3 thin film was cultivated by molecular beam epitaxy (MBE) method on Al2O3 (001) substrate. The orientation between Bi2Se3 and the substrate is Bi2Se3(001)//Al2O3(1 2¯ 10). Conducting mechanism ensued the small-polaron hopping mechanism, with an activation energy of 34 meV. The film demonstrates conductivity of n-type, and the resistivity is 7 × 10−4 Ωcm at room temperature. The Film exhibits an excellent carrier mobility of 1,015 cm2/Vs at room temperature and retains optical transparency in the near-infrared (&gt;70%) and far-infrared (&gt;85%) ranges. To the best of our knowledge, the Bi2Se3 film yields the best result in the realm of n-type Infrared transparent conductive thin films generated through either physical or chemical methods. To demonstrate the application of such films, we produced N-Bi2Se3/P-CuScO2 heterojunction diode device, the ∼3.3 V threshold voltage of which conformed fairly well with the CuScO2 bandgap value. The high optical transparency and conductivity of Bi2Se3 film make it very promising for optoelectronic applications, where a wide wavelength range from near-infrared to far-infrared is required.
NLRP3 in the Cerebrospinal Fluid as a Potential Biomarker for the Diagnosis and Prognosis of Community-Acquired Bacterial Meningitis in Adults
Authors: Gong Zhe , Zhang Chaopeng , Li Yanfei , Jing Lijun , Duan Ranran , Yao Yaobing , Teng Junfang , Jia Yanjie 
Published: January 2022

ObjectiveTo discover the levels of NLR family pyrin domain-containing 3 (NLRP3) in the cerebrospinal fluid (CSF) from adult patients with community-acquired bacterial meningitis (CABM).MethodsWe enrolled 34 patients with CABM, 20 patients with viral meningitis (VM), and 25 patients with non-inflammatory neurological disease. Data on standard clinical parameters, scores, and outcomes were obtained from clinical records, and inflammasome levels in the CSF were measured by an enzyme-linked immunosorbent assay. The area under the receiver operating characteristic curve (AUROC) was used to quantify the diagnostic and prognostic performance of CSF NLRP3 as a biomarker of CABM.ResultsThe levels of NLRP3 were elevated in the CSF of patients with CABM, but levels for ASC, caspase-1, or other inflammasomes did not vary significantly. CSF NLRP3 was positively correlated with clinical severity and with the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte count, albumin quotient (Qalb), and immunoglobulin G quotient (QIgG). Patients with unfavorable outcomes had higher levels of NLRP3 in the CSF, which were correlated with several blood indicators, including NLR, PLR, and lymphocyte and monocyte counts.ConclusionsOur results suggested that the level of CSF NLRP3 could represent the severity of CABM in adults. CSF NLRP3 may be a good biomarker for the diagnosis of CABM and for the discrimination between CABM and VM. It may also be a better biomarker for predicting the prognosis of adult patients with CABM when compared to the NLR or the lymphocyte and monocyte counts.
Evolution of Glacial Lake Cochrane During the Last Glacial Termination, Central Chilean Patagonia (∼47°S)
Authors: Vásquez Alicia , Flores-Aqueveque Valentina , Sagredo Esteban , Hevia Rodrigo , Villa-Martínez Rodrigo , Moreno Patricio I. , Antinao Jose L. 
Published: January 2022

Large ice-dammed lakes developed along the eastern margin of the Patagonian Ice Sheet (PIS) during the Last Glacial Termination (T1). Their spatial/temporal evolution, however, remains poorly constrained despite their importance for deciphering fluctuations of the shrinking PIS, isostatic adjustments, and climate forcing. Here we examine the distribution and age of shoreline features deposited or sculpted by Glacial Lake Cochrane (GLC) in the Lago Cochrane/Pueyrredón (LCP) basin, Central Patagonia, following recession of the LCP glacier lobe from its final Last Glacial Maximum (LGM) moraines. GLC drained initially toward the Atlantic Ocean and continuing ice shrinking opened new drainage routes allowing the discharge toward the Pacific Ocean. We identify five clusters of lake terraces, shorelines, and deltas between elevations ∼600–500 (N5), ∼470–400 (N4), ∼360–300 (N3), ∼230–220 (N2), and ∼180–170 masl (N1) throughout the LCP basin. The distribution of these clusters and associated glaciolacustrine deposits provide constraints for the evolving position of the damming glacier bodies. Elevation gradients within the landform clusters reveal glacio-isostatic adjustments that enable us to quantify the magnitude of deglacial rebound and construct isostatically corrected surfaces for the different phases in the evolution of GLC. Our chronology, based principally on radiocarbon dates from lake sediment cores and new OSL dating, suggests that these phases developed between ∼20.7–19.3 ka (N5), ∼19.3–14.8 ka (N4), ∼14.8–11.3 ka (N3), and shortly thereafter (N2 and N1). The N3 landforms are the most ubiquitous, well-preserved, and voluminous, attributes that resulted from a ∼3,500-year long period of glacial stability, enhanced sediment supply by peak precipitation regime, and profuse snow and ice melting during the most recent half of T1. This scenario differs from the cold and dry conditions that prevailed during the brief N5 phase and the moderate amount of precipitation during the N4 phase. We interpret the limited development of the N2 and N1 landforms as ephemeral stabilization events following the final and irreversible disappearance of GLC after N3. This event commenced shortly after the onset of an early Holocene westerly minimum at pan-Patagonian scale at ∼11.7 ka, contemporaneous with peak atmospheric and oceanic temperatures in the middle and high latitudes of the Southern Hemisphere.
Rotating Algae Biofilm Reactor for Management and Valorization of Produced Wastewater
Authors: Wood Jonathan L. , Takemoto Jon Y. , Sims Ronald C. 
Published: January 2022

Production and enhancement of high value phycocyanin pigment from microalgae biofilms cultured on oilfield and natural gas produced wastewater were investigated. Cyanobacteria isolated from Logan City, Utah, wastewater treatment Lagoons (LLC2) was cultured in produced water using rotating algal biofilm reactors (RABRs). The RABRs were operated under “low” and “high” light conditions and biomass and phycocyanin content were compared. Phycocyanin content was enhanced by growth under low light conditions to a maximum yield of 31.7 mg/g ash-free dry weight (AFDW) biomass for an 87.6% increase in phycocyanin yield. Phycocyanin productivity was equivalent for both the low and high light treatments (327 ± 81 and 305 ± 39 mg/m2/day, respectively), due to the significantly lower AFDW biomass productivity of the low light treatment (2.7 ± 0.4 g/m2-day). An indoor laboratory evaluation of 14 substrata for biofilm growth showed that cotton rope and cotton belt material provided the highest biomass yields. Further evaluation in a pilot-scale outdoor produced wastewater pond showed that the biomass characteristics from the two substrata differed. The corrugated surface area of the cotton rope cultured a biofilm with a large community of non-photosynthetic organisms with an autotrophic index of 507 and a low phycocyanin yield of 3.4 mg/g AFDW. However, the cotton belt substratum cultured a healthy photosynthetic biofilm with an autotrophic index of 127 and a phycocyanin yield of 47.0 mg/g AFDW. These results demonstrate the cultivation of microalgae biomass and valorization of oilfield and natural gas produced wastewater through the design and management of algal-based biofilm photobioreactors.