bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMANFAATAN ENERGI SURYA DALAM PEMBUATAN LAMPU SEBAGAI UPAYA MEMINIMALISIR PENGGUNAAN LISTRIK
Authors: Ramadhan I Gusti , Yunen Irene Aprilita Tiara Putri , Syahrani Dita , Rosdiana Shinta , Al-Ariki Muhammad Rozakullah 
Published: July 2022

Abstrak: Pandemi COVID-19 melumpuhkan berbagai bidang kehidupan manusia, terutama bidang ekonomi yang menyebabkan semakin meningkatnya penggunaan listrik karena segala kegiatan, seperti bekerja dan sekolah dilakukan dari rumah. Sumber energi listrik di permukaan bumi ini sangat terbatas, sedangkan kebutuhan energi listrik di Indonesia terus meningkat. Kesadaran masyarakat untuk berhemat energi listrik masih rendah. Sementara, ada beberapa energi alam yang ramah lingkungan, aman, dan persediaannya tidak terbatas. Salah satu sumber energi tersebut adalah matahari. Tujuan dari pembuatan lampu bertenaga surya ini adalah sebagai inovasi dalam memanfaatkan tenaga surya untuk penerangan di malam hari dan sebagai bentuk penghematan listrik khususnya di Balai Desa Tlasih, Tulangan, Sidoarjo.Adanya permasalahan tersebut membuat mahasiswa Kuliah Kerja Nyata (KKN) Tahun 2020/2021 Universitas Negeri Malang, mengadakan program kegiatan pembuatan lampu bertenaga surya. Dengan adanya program kegiatan tersebut diharapkan dapat meningkatkan kreativitas masyarakat sekitar untuk berinovasi, terutama dalam memanfaatkan sumber daya alam. Kegiatan ini dilakukan melalui beberapa tahapan, yaitu 1) perencanaan, 2) persiapan, 3) pembuatan, 4) uji coba, 5) perbaikan, dan 6) pemasangan lampu di beberapa titik Balai Desa Tlasih. Dengan adanya lampu bertenaga surya ini, permasalahan mengenai kurangnya penerangan di balai desa dapat terselesaikan dan tidak membutuhkan tambahan biaya karena tidak menggunakan energi listrik. Abstract: COVID-19 Pandemic has paralyzed various sectors in human life, particularly in economic which cause the escalation of electricity usage for various activities, such as working and learning from home. Electric sources on the earth are limited, while the demand of electricity continues to increase. The public awareness of electricity saving is still on the low level. Meanwhile, there are several environmentally friendly, safe, and unlimited reserves of natural energy sources. One of those sources of energy is the sun. The aim of creating the solar-powered lamp is as an innovation in utilizing solar power for lighting at night and as a form of saving electricity, especially at the Village Hall of Tlasih, Tulangan, Sidoarjo. With these problems, the students of KKN Universitas Negeri Malang 2020/2021, establish a program to make a solar-powered lamp. This program is expected to increase the public creativity in the village to innovate, especially in utilizing natural resources. This activity was carried out through several stages, namely 1) planning, 2) preparation, 3) manufacture, 4) testing, 5) repairing, and 6) installing lights at several points in the Tlasih Village Hall. With this solar-powered lamp, the lack of lighting problems in the village hall can be resolved and do not need additional charges because it does not use electrical energy.
CLINICAL AND ECONOMIC EVALUATION OF ATEZOLIZUMAB + VEMURAFENIB + COBIMETINIB COMBINATION AND NIVOLUMAB + IPILIMUMAB COMBINATION: ADMINISTRATION IN METASTATIC MELANOMA TREATMENT WITH BRAF-CONFIRMED MUTATION IN ADULT PATIENTS
Authors: Krysanov I. S. , Makarova E. V. , Ermakova V. Yu. 
Published: July 2022

The aim of the study was to conduct a pharmacoeconomic evaluation of the atezolizumab, vemurofenib and cobimetinib (ATZ+VM+COB) combination and the nivolumab and ipilimumab (NIVO+IPI) combination for the treatment of BRAF-confirmed metastatic melanoma in adult patients.Materials and methods. With the help of mathematical modeling methods, a pharmacoeconomic “cost-effectiveness” analysis; a “budget impact” analysis; a sensitivity analysis to the changes in the initial parameters of the model, were carried out.Results. The analysis of literature sources made it possible to conclude that the combination of ATZ+VM+COB compared with the combination of NIVO+IPI (15.1 and 11.2 months, respectively) has a greater clinical efficacy in terms of a progression-free survival (PFS) in patients with metastatic melanoma. When choosing the ATZ+VM+COB combination, the total cost of treatment for one adult patient with metastatic melanoma per course was lower, compared to the NIVO+IPI combination (RUB 8 326 864.89 vs RUB 7 172 751.68); the difference amounted to 1 154 113.21 rubles. When calculating the “cost-effectiveness” ratio for a year of a progression-free survival, the advantage of the ATZ + VM + COB combination in comparison with the NIVO + IPI combination, remained (5 700 200.01 rubles vs 8 942 400.10 rubles); the difference amounted to 3 242 200.09 rubles. The sensitivity analysis demonstrated the developed model stability to an increase in the cost of the ATZ + VM + COB course up to + 16%, a decrease in the cost of the NIVO + IPI course to –13%, and a reduction in the PFS to –37% against the background of the ATZ + VM + COB course. The “budget impact” analysis showed the possibility of reducing costs by 8 655 849.11 rubles with an increase from 5% to 20% in the proportion of the patients administrated with the ATZ+VM+COB combination, and with a decrease from 95% to 80% in the proportion of the patients administrated with the NIVO+IPI combination.Conclusion. The results of the work have shown that within the healthcare system of the Russian Federation, the triple combination of ATZ+VM+COB is a clinically cost-effective option for the treatment of adult metastatic melanoma patients with a confirmed BRAF mutation.
Critical brain wave physics of neuronal avalanches without sandpiles of self organized criticality
Authors: Galinsky Vitaly , Frank Lawrence 
Published: July 2022

Abstract
Analytical expressions for scaling of brain wave spectra derived from the general nonlinear wave Hamiltonian form show excellent agreement with experimental ``neuronal avalanche'' data. The theory of the weakly evanescent nonlinear brain wave dynamics1,2 reveals the underlying collective processes hidden behind the phenomenological statistical description of the neuronal avalanches and connects together the whole range of brain activity states, from oscillatory wave-like modes, to neuronal avalanches, to incoherent spiking, showing that the neuronal avalanches are just the manifestation of the different nonlinear side of wave processes abundant in cortical tissue. In a more broad way these results show that a system of wave modes interacting through all possible combinations of the third order nonlinear terms described by a general wave Hamiltonian necessarily produces anharmonic wave modes with temporal and spatial scaling properties that follow scale free power laws. To the best of our knowledge this has never been reported in the physical literature and may be applicable to many physical systems that involve wave processes and not just to neuronal avalanches.
Assessing the effectiveness of the TaMATE1B and TaALMT1 genes to enhance the Al3+ tolerance of durum wheat (Triticum turgidum) grown under controlled conditions and in the field.
Authors: Kawasaki Akitomo , Wasson Anton , Kielnhofer Evangeline , Ryan Peter , Delhaize Emmanuel 
Published: July 2022

Abstract
Purpose
Durum wheat is sensitive of acid soils because it lacks effective genes for Al3+ tolerance. Previous research showed introgression of the bread wheat (Triticum aestivum) TaMATE1B and TaALMT1 genes individually increased the Al3+ tolerance of durum wheat. Here we aimed to (a) combine the genes into a single durum line, (b) compare the various introgression lines to each another and (c) establish the effectiveness of the introgressions in improving tolerance of acid soils in the field.
Methods
Durum wheat lines homozygous for Al3+-tolerant alleles of TaMATE1B and TaALMT1 were crossed to develop a line that incorporated both genes. The lines comprised of Jandaroi (parental cultivar), TaMATE1B-Jandaroi, TaALMT1-Jandaroi and TaMATE1B + TaALMT1-Jandaroi were screened for Al3+ tolerance by hydroponic and soil cultures in a growth cabinet. The lines were also assessed for biomass production and grain yield in the field on acid soils.
Results
The durum wheat lines with the various Al3+-tolerance genes introgressed performed better based on root growth than Jandaroi, the parental cultivar, in both hydroponic and soil assays when grown in a cabinet. The various introgression lines were tolerant of acid soils compared to Jandaroi when grown in the field as assessed by shoot biomass and grain yield.
Conclusion
The TaALMT1 and TaMATE1B genes improve the acid soil tolerance of durum wheat with indications that combing the two genes is the most effective strategy. The various lines will be valuable to breeders who wish to enhance the acid soil tolerance of durum germplasm.
Handheld NDVI Sensor-based Rice Productivity Assessment under Combinations of Fertilizer Soil Amendment and Irrigation Water Management in Lower Moshi Irrigation Scheme, Tanzania
Authors: Kimaro Oforo Didas , Gebre Sintayehu Legesse , Hieronimo Proches , Kihupi Nganga , Feger Karl-Heinz , Kimaro Didas N. 
Published: July 2022

Abstract
Handheld Optical Sensor was used to measure canopy reflectance at red region (656 nm) and near-infrared region (774 nm) to generate NDVI data for monitoring rice productivity under soil amendment with combinations of fertilizers at two levels of water regime in smallholder Irrigation Scheme, in Lower Moshi, Tanzania. The study was carried out in an experimental design consisted of two irrigation water levels (flooding and system of rice intensification) with multi-nutrients (NPK) and single nutrient (urea) application replicated three times in a randomized complete block design. Flood irrigation water was applied at 7 cm height throughout the growing season, while SRI treatment irrigation water was applied at 4 cm height under alternate wetting and drying conditions. The annual rate of fertilizers applied was 120 kg N/ha, 20 kg P/ha, and 25 kg K/ha. The variety SARO-5 was used in this experiment. Simple correlation coefficient (r) was used to measure the degree of association between field crop performance parameters (plant height, number of tillers, biomass, yield) and NDVI across growth stages and three positions of the sensor above the canopy in the tested fertiliser combinations and water regimes. Results show that at any given fertiliser combinations and water levels, there was no significant correlation between plant height and NDVI except for the plant height at a vegetative stage for 0.6 m above the crop canopy and booting stage at 0.3 m and 0.6 m above the canopy respectively (p < 0.05). A good correlation was also observed between NDVI at booting and full booting stage regardless of the position of the sensor above the canopy and the number of tillers at full booting growth stage (p < 0.05). A significant relationship was observed between rice grain yield and NDVI at the vegetative, booting, and full booting stage. The simple linear regression models explained only slightly less than 30% of the yield predictions by NDVI at the early stage of the crop growth, decreasing gradually to 5% at the full booting growth stage. Results from this study have demonstrated a positive linear relationship between rice grain yield and NDVI for the tested soil fertiliser amendments and irrigation water regimes. The study conclude that handheld NDVI-based sensor can be used in smallholder rice yield predictions for optimising soil fertiliser use and irrigation water management.
Regulation of Community Advisory Boards During Conduct of Clinical Trials in Uganda; a qualitative study involving Stakeholders
Authors: Mijumbi Andrew Ojok , Mugenyi Levicatus , Nanfuka Mastula , Agaba Collins , Ochieng Joseph 
Published: July 2022

Abstract
Background: Community advisory structures such as Community Advisory Boards (CABs) play an important role of helping researchers to better understand the community at each phase of the clinical trial. CABs can be a source of accurate information on the community, its perception of proposed research and may identify factors that make community members vulnerable to the problem under investigation. Although CABs help to build mutually beneficial relationships between the researcher(s) and the communities in which the clinical trial is being implemented, meaningful engagement would require ethical guidance and regulatory oversight. The study assessed the stakeholders’ perspectives regarding the regulatory oversight of CABs in Uganda Methods: This was a cross-sectional study employing qualitative methods of data collection and analysis. Key informant interviews (KIIs) with the trial investigators, CAB chairpersons, community liaison officers, regulators and REC chairpersons were conducted. A KII guide was designed and utilized during key informant interviews. The guide included questions on role of investigators and CAB members in clinical trials; challenges of community engagement; facilitation of CABs; regulatory oversight of CABs; work relationships between investigators and CABs; and opinions on how community trials should be conducted among others. All interviews were conducted in English. Qualitative data were transcribed verbatim. A code book was generated based on the transcripts and study objectives. Thematic analysis was used to analyze qualitative data in Atlas ti based on emerging themes and sub-themes and in line with the study objectives. Results: Of the 34 respondents, 29.4% were investigators, 29.4% CAB chairpersons, 29.4% research regulators/REC Chairs and 11.8% community liaison officers. Fifty-nine percent were male and had varying occupations and demographic characteristics. Content analysis identified themes including the current practices for CAB establishment and monitoring; need for regulatory oversight; appropriate training and skills; and challenges faced by CABs. Conclusion: There is need for regulatory oversight of CABs based on contextualized ethical guidelines as well as capacity strengthening in terms of training and skills development.
Identifying Factors Across Multiple Scales That Impact Bat Activity and Species Richness in a Fragmented Landscape
Authors: RUSSO-PETRICK KELLY M. , Bowling KAREN V. ROOT 
Published: July 2022

Abstract
Roads have variable impacts on wildlife, including bats. Bat habitat preferences along roads vary across spatial scales, creating the need for multi-scale habitat studies. The main objective of this study was to determine what habitat factors impact bat activity and species richness along road transects at local and landscape scales and to identify areas of highest bat activity in the Oak Openings Region of Northwest Ohio using acoustic monitoring. At the local scale, bat activity and/or species richness were positively associated with canopy height, clutter at 0-3 meters, humidity, natural habitat, canopy cover, months water present, and temperature, and were negatively associated with clutter at 3-6.5 meters. At the landscape scale, activity and/or richness had positive associations with habitat heterogeneity, roads, open natural habitats, ponds, upland prairie, and overall forest cover, and had negative associations with conifers and cropland. High activity areas were consistent between years and clustered in the northern part of the region, especially near protected areas and low activity areas were typically located in the southern part of the region near agricultural areas. When managing bat habitat along roads, it would be advantageous to decrease mid-level clutter, vary habitat types, increase savanna and upland prairie cover, avoid excessive conifer or cropland cover, plant tall trees, and provide water sources. This study shows that combining acoustic road surveys with habitat analyses at multiple scales can be used to examine the most important habitat factors influencing bat activity and species richness.
Development and characterization of Aluminium AA7075 hybrid composite foams (AHCFs) using SiC and TiB2 Reinforcement
Authors: Singh Nitish Kumar , Sethuraman Balaguru 
Published: July 2022

Abstract
In this study AA7075/SiC/TiB2 closed-cell Aluminium hybrid composite foam (AHCFs) with different densities was fabricated by top-loaded bottom pouring stir casting technique. This technique uses oyster-shell powders (CaCO3 2.5 wt. % of composite with 60 μm size) as blowing agents and no viscosity-enhancing ingredient. The silicon carbide (SiC 0, 3, 6, 9, and 12 wt. % with 25 μm) and titanium di-boride (TiB2 3 wt. % with particle size 15 μm) are used as primary and secondary reinforcement agents. It has been noted that the addition of TiB2 and SiC enhanced the mechanical properties (modulus of elasticity, yield strength, and plateau strength) of AHCFs. The energy absorption capacity of AHCFs increases with the addition of SiC up to 3 wt. % and a further increase in SiC content leads to the reduction. It is observed that density and cell wall thickness increases with increasing the wt. % of SiC and Cell size and porosity decrease with an increase in wt. %. of reinforcement. It is also noted that Stirring temperature also strongly influenced the microstructural properties of AHCFs, and 750 0C of stirring temperature is sufficient for aluminium foaming.
First publication of endemic channels as part of a pediatric Antimicrobial Stewardship Program: when to turn on the alarms? Recommendations of a pediatric ASP program
Authors: Londoño-Ruiz Juan Pablo , Gutierrez-Tobar Ivan Felipe , Bermúdez-Bohórquez Naddya Lheidy , Rodriguez-Hernandez Andrea Esperanza 
Published: July 2022

Abstract
Background
Pediatric Antimicrobial Stewardship Programs (ASP) consider DOT a fundamental measure to quantify the impact of ASP. Novel strategies have been described, but no endemic channels (EC) have been reported to compare antibiotic use within historical patterns. This report describes the process of constructing an EC and analyzing its interpretation.
Methods
This was a descriptive study of the construction, implementation, and analysis of EC. The median and quartile method, as well as the geometric mean (GM) and confidence interval (CI) methods using DOT for the last 4 years were used. ECs have also been elaborated on in critical services (PICU).
Results
GM and CI method was more sensitive in identifying changes in antimicrobial use. Ceftriaxone increased its use starting in December 2021, reaching the warning zone in March 2022 in relation to increased cases of bacterial and complicated pneumonia. Piperacillin–tazobactam showed an important increase in PICU during the first 8 months of 2021, reaching the alert zone until August 2021; thereafter, its use decreased, and this variation was related to a modification in the presentation of complicated appendicitis during the COVID 19 pandemic restrictions. The use of ampicillin-sulbactam has increased since January 2022 because of a change in local guidelines regarding its use in appendicitis and peritonitis. The changes identified in each EC allowed ASP to take different conducts.
Conclusion
EC allowed us to construct a new tool to measure ASP impact, internal comparison of antibiotic use facilitated taking timely interventions. EC could be useful for all pediatric and adult ASP.
Analysis of intermunicipal journeys for cardiac surgery in Brazilian Unified Health System (SUS): an approach based on network theory
Authors: Sousa Ludmilla Monfort Oliveira , Pereira Hernane Borges de Barros , de Araújo Edna Maria , Miranda José Garcia Vivas 
Published: July 2022

Abstract
Introduction: The transformation of data into information is important to support decision making and, thus, to induce improvements in healthcare services. The regionalized organization of healthcare systems is necessary to ensure the integrity of citizen care. From this perspective, the creation of mechanisms to guide and assess the behavior of a healthcare services network becomes necessary. However, these mechanisms must consider the interaction between different municipalities. The objective of this study is to apply network analysis as a supporting tool in the Brazilian Unified Health System (Sistema Único de Saúde - SUS) management. Methods: the stages of the proposed method are described and applied in a real situation, analyzing the intermunicipal interaction network for cardiovascular surgery in the municipality of Vitória da Conquista, Bahia, Brazil, from 2008 to 2020. The metrics analyzed were journeys indices, flow of patients and distance of the journeys, considering the journeys from and to the municipality in focus. Result: there was an increase of the incoming flow and in-degree indices combined with a decrease in outgoing flow, showing the growing importance of this municipality as a provider of these services. Conclusion: the method used in the study has potential to be adopted as a management tool to assess the behavior of the interactions network of the selected service, aiding the regionalized organization of the healthcare system.
A novel glycosylation-related gene signature predicts survival in patients with lung adenocarcinoma
Authors: Liang Jinxiao , Chen Qian , Chen Da , Gao Wei , Qian Xinyu , Bi Jinqiao , Han Bingbing , Lin Xingchen , Liu Jinshi 
Published: July 2022

Abstract
Background:
Lung adenocarcinoma (LUAD) is the most common malignant tumor that seriously affects a huge number of human health. It is reported that abnormal levels of glycosylation promote the progression and poor prognosis of lung cancer. Hence, we aimed to explore the prognostic signature related to glycosyltransferases (GTs) for LUAD.
Method:
Based on the data of gene expression profiles obtained from The Cancer Genome Atlas (TCGA) database and GTs obtained from the GlycomeDB database, we identified differentially expressed GTs-related genes (DGTs) between control and LUAD samples. The latent functions and pathways of DGTs were detected by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and ingenuity pathway analysis (IPA) methods. Univariate and multivariate Cox regression analyses were then performed to screen the candidate prognostic genes to conduct a prognostic risk model for LUAD. Kaplan-Meier(K-M) curve was operated to assess the overall survival (OS) of LUAD patients. The accuracy and specificity of the constructed risk model were evaluated by receiver operating characteristic analysis (ROC). In addition, the infiltrating immune cells in the tumor environment were analyzed using the single-sample gene set enrichment analysis (ssGSEA) algorithm.
Results:
A total of 48 DGTs were identified, contained 37 upregulated and 11 downregulated DGTs, which were mainly enriched in the processes of glycosylation, glycoprotein biosynthetic process, glycosphingolipid biosynthesis-lacto and neolacto series, and cell-mediated immune response. Furthermore, B3GNT3, MFNG, GYLTL1B, ALG3, and GALNT13 were screeded as prognostic genes to construct a risk model for LUAD that divided patients into a high-and low-risk group. K-M curve analysis suggested that high-risk patients showed shorter OS compared with low-risk patients. ROC analysis demonstrated the risk model presented a better ability for diagnosing LUAD. Additionally, the portion of infiltrating aDC and Tgd were higher in the high-risk group than the low-risk group. Spearman correlation analysis manifested that the prognostic genes (MFNG and ALG3) were significantly correlated with infiltrating immune cells.
Conclusion:
We established a novel GTs-related risk model for the prognosis of LUAD patients, providing new therapeutic targets for LUAD.