bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitogenome selection in the evolution of key ecological strategies in the ancient hexapod class Collembola
Authors: Monsanto Daniela M. , Main Devon C. , Janion-Scheepers Charlene , Emami-Khoyi Arsalan , Deharveng Louis , Bedos Anne , Potapov Mikhail , Parbhu Shilpa P. , Le Roux Johannes J. , Teske Peter R. , van Vuuren Bettine Jansen 
Published: August 2022

AbstractA longstanding question in evolutionary biology is how natural selection and environmental pressures shape the mitochondrial genomic architectures of organisms. Mitochondria play a pivotal role in cellular respiration and aerobic metabolism, making their genomes functionally highly constrained. Evaluating selective pressures on mitochondrial genes can provide functional and ecological insights into the evolution of organisms. Collembola (springtails) are an ancient hexapod group that includes the oldest terrestrial arthropods in the fossil record, and that are closely associated with soil environments. Of interest is the diversity of habitat stratification preferences (life forms) exhibited by different species within the group. To understand whether signals of positive selection are linked to the evolution of life forms, we analysed 32 published Collembola mitogenomes in a phylomitogenomic framework. We found no evidence that signatures of selection are correlated with the evolution of novel life forms, but rather that mutations have accumulated as a function of time. Our results highlight the importance of nuclear-mitochondrial interactions in the evolution of collembolan life forms and that mitochondrial genomic data should be interpreted with caution, as complex selection signals may complicate evolutionary inferences.
Numerical study on existing RC circular section members under unequal impact collision
Authors: Yanhui Liu , Al-Bukhaiti Khalil , Shichun Zhao , Abas Hussein , Nan Xu , Lang Yang , Yu Yan Xing , Daguang Han 
Published: August 2022

AbstractTraffic accidents and derailed train-related incidents have occurred more often than ever in recent years, resulting in some economic damage and casualties. Reinforced concrete (RC) constructions often involve derailed train and vehicle accidents. Rarely are such side collisions studied in previous studies. To do this, high-fidelity simulation-based finite-element (FE) models are created in this paper to accurately simulate the collision of circular RC members with a derailed train. The reinforced concrete member structure is common in high-speed railway stations. The impact energy of the impact body is significant, causing structural member failure. It analyses the dynamic behavior of reinforced concrete members under unequal span impact loads. Numerical implementations of impact issues are discussed from the perspective of geometric, contact, and material properties. The reliability and precision of the ABAQUS code to solve impact issues are verified by comparing failure modes, impact, and deflection time history experimental outputs. By analysing the impact response characteristics, used the control variables to study the failure process and mode (including the characteristics of impact and reaction forces, deflection time history curve, impact force–deflection curve, and bearing reaction force–deflection curve). The reinforcement ratio, impact velocity, concrete strength, and slenderness ratio significantly affect shear crack pattern and development. Changes in impact velocity and slenderness ratio also affect member failure modes.
Novel mediators of idiopathic pulmonary fibrosis
Authors: Saito Shigeki , Deskin Brian , Rehan Mohammad , Yadav Santosh , Matsunaga Yasuka , Lasky Joseph A. , Thannickal Victor J. 
Published: August 2022

Abstract
Fibrosis involving the lung may occur in many settings, including in association with known environmental agents, connective tissue diseases, and exposure to drugs or radiation therapy. The most common form is referred to as ‘idiopathic’ since a causal agent or specific association has not been determined; the strongest risk factor for idiopathic pulmonary fibrosis is aging. Emerging studies indicate that targeting certain components of aging biology may be effective in mitigating age-associated fibrosis. While transforming growth factor-β1 (TGF-β1) is a central mediator of fibrosis in almost all contexts, and across multiple organs, it is not feasible to target this canonical pathway at the ligand–receptor level due to the pleiotropic nature of its actions; importantly, its homeostatic roles as a tumor-suppressor and immune-modulator make this an imprudent strategy. However, defining targets downstream of its receptor(s) that mediate fibrogenesis, while relatively dispenable for tumor- and immune-suppressive functions may aid in developing safer and more effective therapies. In this review, we explore molecular targets that, although TGF-β1 induced/activated, may be relatively more selective in mediating tissue fibrosis. Additionally, we explore epigenetic mechanisms with global effects on the fibrogenic process, as well as metabolic pathways that regulate aging and fibrosis.
Clinical Guidelines for Eliciting Discourse Using the RHDBank Protocol
Authors: Minga Jamila , Stockbridge Melissa D. , Durfee Alexandra , Johnson Melissa 
Published: August 2022

Purpose:Examining discourse after right hemisphere brain damage (RHD) can provide invaluable clinical data and insight into functional communication capabilities. Yet, clinicians preparing to enter the field may have limited experience eliciting and analyzing discourse for therapeutic purposes. The purpose of this work is to present a practical guide for the clinical use of the RHDBank protocol.Method:Following a brief overview of the RHDBank protocol, elicitation guidelines and protocol administration considerations are offered. Measures that should be considered when analyzing RHDBank-elicited discourse are summarized. The RHDBank protocol is positioned as an accessible resource for discourse elicitation in the clinical setting, and examples for the clinical use of the protocol are provided.Conclusions:Discourse production can be a key source of information regarding communication ability following RHD. The RHDBank provides a structured and scripted approach to the clinical elicitation of language and consideration of discourse production. Its immediate clinical utility will assist developing clinicians with the acquisition of a clinically relevant elicitation approach and more comprehensive view of the RHD communication impairments. Application of the protocol can aid in collective knowledge advancement that will promote a better understanding of RHD language production as a clinical entity with an array of possible characteristics.
Glottal Stop Production in Controls and Patients With Unilateral Vocal Fold Paresis/Paralysis
Authors: Stager Sheila V. , Maryn Youri 
Published: August 2022

Purposes:
The purposes of this study were to determine whether the acoustic measures from glottal stops distinguished between controls and patients with unilateral vocal fold paresis/paralysis (UVFP) at initial evaluation and posttreatment/observation, to explore the types of false vocal fold (FVF) movement during glottal stop production in UVFP, and to assess the agreement between normalization of various measures and reported voice normalization.

Method:
Patients with UVFP and controls were recorded acoustically and laryngoscopically speaking two sets of five repeated /i/s, controls once and patients with UVFP initially and posttreatment/observation. Averaged intensity differences and slopes for offsets (maximum voicing intensity to minimum glottal stop intensity) and onsets (minimum glottal stop intensity to maximum voicing intensity) were measured. FVF movements were rated separately for paretic and nonparetic sides. Patients were asked to report voice normalization posttreatment/observation. Cohen's kappas were calculated for agreements between patient-reported voice normalization and normalization of Voice-Related Quality of Life (V-RQOL), translaryngeal flow, four acoustic measures of glottal stop production, and FVF movement.

Results:

Significant differences (analysis of variance [ANOVA];
p
< .014) were found for all acoustic measures between controls and patients with UVFP and between patients with UVFP initially and posttreatment/observation (paired
t
tests;
p
< .05). In addition, 78% of UVFP patients had no FVF movement on the paretic side initially, and 42% had bilateral dynamic FVF movement posttreatment/observation. Cohen's kappa showed moderate agreement between voice normalization and V-RQOL, slight agreement with offset measures, and fair agreement with onset measures.

Conclusion:
This study provided proof of concept for using acoustic measures of glottal stops to distinguish between controls and patients with UVFP, both initially and posttreatment/observation.
What We Learn From Listening to Families in Early Childhood Tele-Intervention During the Pandemic
Authors: Rodríguez-García Lidia , de la Mano-Rodero Paola 
Published: August 2022

Purpose:
Plena Inclusión is the National Federation of Organisations of People with Disabilities in Spain providing services, defending rights, and being an agent of social change. Families who have children with early childhood intervention (ECI) support needs have experienced a changing situation during confinement due to the pandemic. Some of these changes have critically affected some families, whereas others have been able to rely on professional support that has allowed them to develop strengths and improve their functioning as a family. This objective is, precisely, one of the keys to the Family-Centered Practice (FCP) model in ECI. This study aims to explore the narratives of families who have received support in ECI practices during the lockdown in the region of Castilla–La Mancha (Spain) within the frame of Plena Inclusión services. These practices have been directed, in many cases, toward tele-intervention.

Method:
Data have been collected through ethnographic interviews with families and have been processed through thematic analysis.

Results:
The results show the perception of families articulated in two thematic network focuses: the personal and family emotions regarding the past and present moment (fear, loneliness, despair, nervousness, uncertainty, anguish, and frustration) and the emotions experienced also in the present but projected toward future (feeling of competence, hope, adaptation, tranquility as they felt supported by professionals, relief for not being alone, trust in their process, or empowerment, among others).

Conclusions:
In parallel, focus groups with professionals who support these families were carried out, although the results of this analysis will be presented in future reports. The study opens new lines, which evidence the difficulty of the process of transformation toward actual FCPs.
Synchronization for mini‐UAV‐based high‐resolution BiSAR systems: Lost direct signal estimation based on Hampel filtering
Authors: Wang Zhanze , Liu Feifeng , Zhang Shuyao , Xu Zhixiang 
Published: August 2022

AbstractIn mini‐unmanned aerial vehicle‐based high‐resolution bistatic synthetic aperture radar systems, the rotation of the unmanned aerial vehicle platforms will cause direct signal loss, resulting in the reduction of synchronization error compensation accuracy. Here, a synchronization algorithm is proposed to estimate the lost direct signal. First, bistatic time and phase synchronization signal models are established. Then, Hampel filtering is used to estimate the time delay of the lost direct signal, and the time and phase synchronization errors are estimated based on third‐order polynomial fitting. A high‐resolution synthetic aperture radar image is used to demonstrate the validity of the proposed algorithm in mini‐unmanned aerial vehicle‐based high‐resolution bistatic synthetic aperture radar systems.
Vibrationally excited HCN transitions in circumstellar envelopes of carbon-rich AGB stars
Authors: Jeste Manali , Gong Yan , Wong Ka Tat , Menten Karl M. , Kamiński Tomasz , Wyrowski Friedrich 
Published: August 2022

Context. The most abundant molecule after H2 and CO in the circumstellar envelopes (CSEs) of carbon-rich asymptotic giant branch (AGB) stars is HCN. Its rotational lines within vibrationally excited states are exceptional tracers of the innermost region of carbon-rich CSEs.
Aims. We aim to constrain the physical conditions of CSEs of carbon-rich stars using thermal lines of the HCN molecule. Additionally, we also search for new HCN masers and probe the temporal variations for HCN masers, which should shed light on their pumping mechanisms.
Methods. We observed 16 carbon-rich AGB stars in various HCN rotational transitions, within the ground and 12 vibrationally excited states, with the Atacama Pathfinder Experiment (APEX) 12-metre sub-millimetre telescope.
Results. We detect 68 vibrationally excited HCN lines from 13 carbon-rich stars, including 39 thermal transitions and 29 maser lines, suggesting that vibrationally excited HCN lines are ubiquitous in carbon-rich stars. Population diagrams constructed for two objects from the sample, for thermal transitions from different vibrationally excited states, give excitation temperatures around 800–900 K, confirming that they arise from the hot innermost regions of CSEs (i.e. r <20 R*). Among the detected masers, 23 are newly detected, and the results expand the total number of known HCN masers lines towards carbon-rich stars by 47%. In particular, the J = 2−1 (0, 3le, 0), J = 3−2 (0, 2, 0), and J = 4−3 (0, 11f, 0) masers are detected in an astronomical source for the first time. Our observations confirm temporal variations of the 2−1 (0, 11e, 0) maser on a timescale of a few years. Our analysis of the data suggests that all detected HCN masers are unsaturated. A gas kinetic temperature of ≳700 K and an H2 number density of >108 cm−3 are required to excite the HCN masers. In some ways, HCN masers in carbon-rich stars might be regarded as an analogy of SiO masers in oxygen-rich stars.
The importance of Fe fragmentation for LiBeB analyses
Authors: Maurin D. , Ferronato Bueno E. , Génolini Y. , Derome L. , Vecchi M. 
Published: August 2022

Context.High-precision data from AMS-02 on Li, Be, and B provide the best constraints on Galactic cosmic-ray transport parameters.Aims.We re-evaluate the impact of Fe fragmentation on the Li, Be, and B modelling. We discuss the consequences on the transport parameter determination and reassess whether a primary source of Li is needed to match AMS-02 data.Methods.We renormalised several cross-section parametrisations to existing data for the most important reactions producing Li, Be, and B. We used theUSINEcode with these new cross-section sets to re-analyse Li/C, Be/C, and B/C AMS-02 data.Results.We built three equally plausible cross-section sets. Compared to the initial cross-section sets, they lead to an average enhanced production of Li (∼20 − 50%) and Be (∼5 − 15%), while leaving the B flux mostly unchanged. In particular, Fe fragmentation is found to contribute to up to 10% of the Li and Be fluxes. Used in the combined analysis of AMS-02 Li/C, Be/C, and B/C data, the fit is significantly improved, with an enhanced diffusion coefficient (∼20%). The three updated cross-section sets are found to either slightly undershoot or overshoot the Li/C and B/C ratios: this strongly disfavours evidence for a primary source of Li in cosmic rays. We stress that isotopic cosmic-ray ratios of Li (and to a lesser extent Be), soon to be released by AMS-02, are also impacted by the use of these updated sets.Conclusions.Almost no nuclear data exist for the production of Li and B isotopes from Ne, Mg, Si, and Fe, whereas these reactions are estimated to account for ∼20% of the total production. New nuclear measurements would be appreciated and help to better exploit the high-precision AMS-02 cosmic-ray data.
TOPz: Photometric redshifts for J-PAS
Authors: Laur J. , Tempel E. , Tamm A. , Kipper R. , Liivamägi L. J. , Hernán-Caballero A. , Muru M. M. , Chaves-Montero J. , Díaz-García L. A. , Turner S. , Tuvikene T. , Queiroz C. , Bom C. R. , Fernández-Ontiveros J. A. , González Delgado R. M. , Civera T. , Abramo R. , Alcaniz J. , Benítez N. , Bonoli S. , Carneiro S. , Cenarro J. , Cristóbal-Hornillos D. , Dupke R. , Ederoclite A. , López-Sanjuan C. , Marín-Franch A. , de Oliveira C. M. , Moles M. , Sodré L. , Taylor K. , Varela J. , Ramió H. V. 
Published: August 2022

Context.The importance of photometric galaxy redshift estimation is rapidly increasing with the development of specialised powerful observational facilities.Aims.We develop a new photometric redshift estimation workflow TOPz to provide reliable and efficient redshift estimations for the upcoming large-scale survey J-PAS which will observe 8500 deg2of the northern sky through 54 narrow-band filters.Methods.TOPz relies on template-based photo-zestimation with some added J-PAS specific features and possibilities. We present TOPz performance on data from the miniJPAS survey, a precursor to the J-PAS survey with an identical filter system. First, we generated spectral templates based on the miniJPAS sources using the synthetic galaxy spectrum generation software CIGALE. Then we applied corrections to the input photometry by minimising systematic offsets from the template flux in each filter. To assess the accuracy of the redshift estimation, we used spectroscopic redshifts from the DEEP2, DEEP3, and SDSS surveys, available for 1989 miniJPAS galaxies withr <22 magAB. We also tested how the choice and number of input templates, photo-zpriors, and photometric corrections affect the TOPz redshift accuracy.Results.The general performance of the combination of miniJPAS data and the TOPz workflow fulfills the expectations for J-PAS redshift accuracy. Similarly to previous estimates, we find that 38.6% of galaxies withr< 22 mag reach the J-PAS redshift accuracy goal of dz/(1 +z) < 0.003. Limiting the number of spectra in the template set improves the redshift accuracy up to 5%, especially for fainter, noise-dominated sources. Further improvements will be possible once the actual J-PAS data become available.
Endoscopic ultrasound-guided fine-needle biopsy with or without macroscopic on-site evaluation: a randomized controlled noninferiority trial
Authors: Mangiavillano Benedetto , Crinò Stefano Francesco , Facciorusso Antonio , Di Matteo Francesco , Barbera Carmelo , Larghi Alberto , Rizzatti Gianenrico , Carrara Silvia , Spadaccini Marco , Auriemma Francesco , Fabbri Carlo , Binda Cecilia , Coluccio Chiara , Marocchi Gianmarco , Staiano Teresa , Conti Bellocchi Maria Cristina , Bernardoni Laura , Eusebi Leonardo Henri , Cirota Giovanna Grazia , De Nucci Germana , Stigliano Serena , Manes Gianpiero , Bonanno Giacomo , Ofosu Andrew , Lamonaca Laura , Paduano Danilo , Spatola Federica , Repici Alessandro 
Published: August 2022

Background The advantage of using the macroscopic on-site evaluation (MOSE) technique during endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) performed with 22G Franseen needles has not been investigated. We aimed to compare EUS-FNB with MOSE vs. EUS-FNB performed with three needle passes.
Methods This randomized trial involved 10 Italian referral centers. Consecutive patients referred for EUS-FNB of pancreatic or nonpancreatic solid lesions were included in the study and randomized to the two groups. MOSE was performed by gross visualization of the collected material by the endoscopists and considered adequate when a white/yellowish aggregate core longer than 10 mm was retrieved. The primary outcome was diagnostic accuracy. Secondary outcomes were specimen adequacy, number of needle passes, and safety.
Results 370 patients with 234 pancreatic lesions (63.2 %) and 136 nonpancreatic lesions (36.8 %) were randomized (190 EUS-FNB with MOSE and 180 with standard EUS-FNB). No statistically significant differences were found between EUS-FNB with MOSE and conventional EUS-FNB in terms of diagnostic accuracy (90.0 % [95 %CI 84.8 %–93.9 %] vs. 87.8 % [95 %CI 82.1 %–92.2 %]; P = 0.49), sample adequacy (93.1 % [95 %CI 88.6 %–96.3 %] vs. 95.5 % [95 %CI 91.4 %–98 %]; P = 0.31), and rate of adverse events (2.6 % vs. 1.1 %; P = 0.28). The median number of passes was significantly lower in the EUS-FNB with MOSE group (1 vs. 3; P < 0.001).
Conclusions The accuracy of EUS-FNB with MOSE is noninferior to that of EUS-FNB with three needle passes. MOSE reliably assesses sample adequacy and reduces the number of needle passes required to obtain the diagnosis with a 22G Franseen needle.
Improving Asthma Care Documentation with a Digital Tool–Experience in a Pediatric Institution
Authors: de Groot Stormie , Lawrence Joanna , Liddle James , Campbell Janice , Cheng Daryl R. 
Published: August 2022

Abstract
Background Asthma affects approximately 10% of Australian children. Electronic medical record (EMR) systems and clinical decision support initiatives have been shown to improve the delivery of asthma care. Our institution implemented an EMR-based asthma “hub,” which collates asthma-related information to a central location within a patient's record, provides a template to collect relevant clinical information, allows clinicians to evaluate a patient's history and presentation in a systematic manner and prompts relevant actions.
Objective The aim of the study is to measure year-on-year improvement in asthma-related documentation and provide a key gold-standard aspects of asthma management after the introduction of an EMR asthma “hub” tool in the outpatient setting.
Methods The asthma “hub” was introduced in November 2020. A chart review was conducted of all patients who attended the Complex Asthma Clinic between January-April 2020 and January-April 2021. The provision and presence of documentation of core aspects of asthma care were described in percentages and comparisons of pre- and post-introduction of the asthma “hub” were assessed.
Results There was a significant increase in the documentation of asthma triggers, including smoking/smoker exposure, (47.5–92.6%, p <0.001), current asthma action plans (70.4–86.3%, p = 0.02), and severity scores (46.3–81%, p <0.001) post the introduction of the asthma “hub.” There was no significant difference in documentation of reliever (as required) or regular preventer medications.
Conclusion An evidence-based EMR intervention improved the documentation and provision of aspects of asthma care in an outpatient clinic setting at a tertiary pediatric hospital, suggesting replication in the inpatient and emergency settings would be worthwhile. Further research is required to understand the tool's impact on clinical outcomes and on clinical efficiency and workflow.
Back to the Basics: Inferior Vena Cava Filters
Authors: Covello Brian , Radvany Martin 
Published: August 2022

AbstractInferior vena cava filters are an important therapeutic option for patients with venous thromboembolism and contraindication to anticoagulation. Indications for filter placement have varied over the previous decades. This article discusses the history of inferior vena cava filter use, with a basic overview of technology and specific devices. Finally, this article reviews emerging filter design and technology. Understanding the basics of inferior vena cava filters is critical to building more robust clinical data for the purpose of improving patient outcomes.