bluuebunny/crossref_metadata_2025_split huggingface dataset:
A scoping review of risk-stratified bowel screening: current evidence, future directions
Authors: Cairns J. M. , Greenley S. , Bamidele O. , Weller D. 
Published: March 2022

Abstract
Purpose
In this scoping review, we examined the international literature on risk-stratified bowel screening to develop recommendations for future research, practice and policy.

Methods
Six electronic databases were searched from inception to 18 October 2021: Medline, Embase, PsycINFO, CINAHL, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials. Forward and backwards citation searches were also undertaken. All relevant literature were included.

Results
After de-deduplication, 3,629 records remained. 3,416 were excluded at the title/abstract screening stage. A further 111 were excluded at full-text screening stage. In total, 102 unique studies were included. Results showed that risk-stratified bowel screening programmes can potentially improve diagnostic performance, but there is a lack of information on longer-term outcomes. Risk models do appear to show promise in refining existing risk stratification guidelines but most were not externally validated and less than half achieved good discriminatory power. Risk assessment tools in primary care have the potential for high levels of acceptability and uptake, and therefore, could form an important component of future risk-stratified bowel screening programmes, but sometimes the screening recommendations were not adhered to by the patient or healthcare provider. The review identified important knowledge gaps, most notably in the area of organisation of screening services due to few pilots, and what risk stratification might mean for inequalities.

Conclusion
We recommend that future research focuses on what organisational challenges risk-stratified bowel screening may face and a consideration of inequalities in any changes to organised bowel screening programmes.
Verifying Whiley Programs with Boogie
Authors: Pearce David J. , Utting Mark , Groves Lindsay 
Published: March 2022

AbstractThe quest to develop increasingly sophisticated verification systems continues unabated. Tools such as Dafny, Spec#, ESC/Java, SPARK Ada and Whiley attempt to seamlessly integrate specification and verification into a programming language, in a similar way to type checking. A common integration approach is to generate verification conditions that are handed off to an automated theorem prover. This provides a nice separation of concerns and allows different theorem provers to be used interchangeably. However, generating verification conditions is still a difficult undertaking and the use of more “high-level” intermediate verification languages has become commonplace. In particular, Boogie provides a widely used and understood intermediate verification language. A common difficulty is the potential for an impedance mismatch between the source language and the intermediate verification language. In this paper, we explore the use of Boogie as an intermediate verification language for verifying programs in Whiley. This is noteworthy because the Whiley language has (amongst other things) a rich type system with considerable potential for an impedance mismatch. We provide a comprehensive account of translating Whiley to Boogie which demonstrates that it is possible to model most aspects of the Whiley language. Key challenges posed by the Whiley language included: the encoding of Whiley’s expressive type system and support for flow typing and generics; the implicit assumption that expressions in specifications are well defined; the ability to invoke methods from within expressions; the ability to return multiple values from a function or method; the presence of unrestricted lambda functions; and the limited syntax for framing. We demonstrate that the resulting verification tool can verify significantly more programs than the native Whiley verifier which was custom-built for Whiley verification. Furthermore, our work provides evidence that Boogie is (for the most part) sufficiently general to act as an intermediate language for a wide range of source languages.
New Emerging Inorganic–Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids
Authors: La Rocca Marzia , Rinaldi Alessia , Bruni Giovanna , Friuli Valeria , Maggi Lauretta , Bini Marcella 
Published: March 2022

AbstractIn the pharmaceutical market, the need to find effective systems for the efficient release of poorly bioavailable drugs is a forefront topic. The inorganic–organic hybrid materials have been recognized as one of the most promising systems. In this paper, we developed new Hydroxypapatite@Furosemide hybrids with improved dissolution rates in different media with respect to the drug alone. The hybrids formation was demonstrated by SEM/EDS measurements (showing homogeneous distribution of the elements) and FT-IR spectroscopy. The drug was adsorbed onto hydroxyapatite surfaces in amorphous form, as demonstrated by XRPD and its thermal stability was improved due to the absence, in the hybrids, of melting and decomposition peaks typical of the drug. The Sr substitution on Ca sites in hydroxyapatite allows increasing the surface area and pore volume, foreseeing a high capacity of drug loading. The dissolution tests of the hybrid compounds show dissolution rates much faster than the drug alone in different fluids, and also their solubility and wetting ability is improved in comparison to furosemide alone.
Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function
Authors: Ishizuka Yuta , Mergiya Tadiwos F. , Baldinotti Rodolfo , Xu Ju , Hallin Erik I. , Markússon Sigurbjörn , Kursula Petri , Bramham Clive R. 
Published: March 2022

AbstractActivity-regulated cytoskeleton-associated (Arc) protein plays key roles in long-term synaptic plasticity, memory, and cognitive flexibility. However, an integral understanding of Arc mechanisms is lacking. Arc is proposed to function as an interaction hub in neuronal dendrites and the nucleus, yet Arc can also form retrovirus-like capsids with proposed roles in intercellular communication. Here, we sought to develop anti-Arc nanobodies (ArcNbs) as new tools for probing Arc dynamics and function. Six ArcNbs representing different clonal lines were selected from immunized alpaca. Immunoblotting with recombinant ArcNbs fused to a small ALFA-epitope tag demonstrated binding to recombinant Arc as well as endogenous Arc from rat cortical tissue. ALFA-tagged ArcNb also provided efficient immunoprecipitation of stimulus-induced Arc after carbachol-treatment of SH-SY5Y neuroblastoma cells and induction of long-term potentiation in the rat dentate gyrus in vivo. Epitope mapping showed that all Nbs recognize the Arc C-terminal region containing the retroviral Gag capsid homology domain, comprised of tandem N- and C-lobes. ArcNbs E5 and H11 selectively bound the N-lobe, which harbors a peptide ligand binding pocket specific to mammals. Four additional ArcNbs bound the region containing the C-lobe and C-terminal tail. For use as genetically encoded fluorescent intrabodies, we show that ArcNbs fused to mScarlet-I are uniformly expressed, without aggregation, in the cytoplasm and nucleus of HEK293FT cells. Finally, mScarlet-I-ArcNb H11 expressed as intrabody selectively bound the N-lobe and enabled co-immunoprecipitation of full-length intracellular Arc. ArcNbs are versatile tools for live-cell labeling and purification of Arc, and interrogation of Arc capsid domain specific functions.
The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies
Authors: Soliman Alaa Bahaa Eldeen , Pawluk Shane Ashley , Wilby Kyle John , Rachid Ousama 
Published: March 2022

Abstract
Background
Critical appraisal aids in assessing the quality of scientific literature, which is central to the practice of evidence-based medicine. Several tools and guidelines are available for critiquing and assessing the quality of specific study types. However, limited guidance exists for critical appraisal of clinical pharmacokinetic studies.

Aim
We aimed to achieve experts’ consensus regarding the quality markers for clinical pharmacokinetic studies in an attempt to develop a critical appraisal tool.

Method
Quality markers related to clinical pharmacokinetic studies, were derived from the published literature and categorized according to manuscript reporting domains (abstract, introduction/background, methodology, results, discussion, and conclusion). Questions that aid in appraising pharmacokinetic studies were formulated from these quality markers. Experts were involved in a modified Delphi process to achieve a consensus regarding the formulated questions. The proposed tool was pilot tested on 30 recently published clinical pharmacokinetic studies. Inter-observer agreement was measured to determine the reliability of the included items.

Results
Twenty-five experts consented to participate. Three rounds of a modified Delphi survey were required to generate a consensus for a 21-item tool aimed at appraising the quality of clinical pharmacokinetic studies. When applied to 30 recently published clinical pharmacokinetic studies, most items scored fair to moderate levels of agreement (61.90–95.24%).

Conclusion
The clinical pharmacokinetic critical appraisal tool (CACPK) developed in this study consisted of 21 items aimed at helping an end-user to determine the quality of a pharmacokinetic study. Further studies are warranted to reaffirm the validity and reliability of the CACPK tool.
Sample Size Determination for Interval Estimation of the Prevalence of a Sensitive Attribute Under Randomized Response Models
Authors: Qiu Shi-Fang , Tang Man-Lai , Tao Ji-Ran , Wong Ricky S. 
Published: March 2022

AbstractStudies with sensitive questions should include a sufficient number of respondents to adequately address the research interest. While studies with an inadequate number of respondents may not yield significant conclusions, studies with an excess of respondents become wasteful of investigators’ budget. Therefore, it is an important step in survey sampling to determine the required number of participants. In this article, we derive sample size formulas based on confidence interval estimation of prevalence for four randomized response models, namely, the Warner’s randomized response model, unrelated question model, item count technique model and cheater detection model. Specifically, our sample size formulas control, with a given assurance probability, the width of a confidence interval within the planned range. Simulation results demonstrate that all formulas are accurate in terms of empirical coverage probabilities and empirical assurance probabilities. All formulas are illustrated using a real-life application about the use of unethical tactics in negotiation.
Low-dose CT for lung cancer screening: position paper from the Italian college of thoracic radiology
Authors: Silva Mario , Picozzi Giulia , Sverzellati Nicola , Anglesio Sandra , Bartolucci Maurizio , Cavigli Edoardo , Deliperi Annalisa , Falchini Massimo , Falaschi Fabio , Ghio Domenico , Gollini Paola , Larici Anna Rita , Marchianò Alfonso V. , Palmucci Stefano , Preda Lorenzo , Romei Chiara , Tessa Carlo , Rampinelli Cristiano , Mascalchi Mario 
Published: March 2022

AbstractSmoking is the main risk factor for lung cancer (LC), which is the leading cause of cancer-related death worldwide. Independent randomized controlled trials, governmental and inter-governmental task forces, and meta-analyses established that LC screening (LCS) with chest low dose computed tomography (LDCT) decreases the mortality of LC in smokers and former smokers, compared to no-screening, especially in women. Accordingly, several Italian initiatives are offering LCS by LDCT and smoking cessation to about 10,000 high-risk subjects, supported by Private or Public Health Institutions, envisaging a possible population-based screening program. Because LDCT is the backbone of LCS, Italian radiologists with LCS expertise are presenting this position paper that encompasses recommendations for LDCT scan protocol and its reading. Moreover, fundamentals for classification of lung nodules and other findings at LDCT test are detailed along with international guidelines, from the European Society of Thoracic Imaging, the British Thoracic Society, and the American College of Radiology, for their reporting and management in LCS. The Italian College of Thoracic Radiologists produced this document to provide the basics for radiologists who plan to set up or to be involved in LCS, thus fostering homogenous evidence-based approach to the LDCT test over the Italian territory and warrant comparison and analyses throughout National and International practices.
Digitale Hochschullehre im ersten COVID-19-Semester. Ergebnisse einer Befragung von Lehrenden in Public Health, Medizin und Pflege
Authors: Marchwacka Maria A. , Kugler Joachim , Schaal Tom , Tolks Daniel 
Published: March 2022

Zusammenfassung
Hintergrund
Die COVID-19(„coronavirus disease 2019“)-Pandemie hat die Ad-hoc-Digitalisierung an Hochschulen vorangetrieben. Zugleich stand die digitale Hochschullehre vor der Herausforderung der Ausgestaltung der Lehre im Zusammenhang mit den vorbestehenden Ressourcen, der digitalen und didaktischen Kompetenzen sowie der zur Verfügung stehenden technischen Infrastruktur.

Ziel der Arbeit/Fragestellung
Das Ziel der Umfrage war die Einschätzung der digitalen Lehre, die die Präsenzlehre infolge der COVID-19-Pandemie zum großen Teil bzw. gänzlich ersetzt hat, aus der Perspektive der Lehrenden in Public Health, Medizin und Pflege.

Material und Methode
Die Querschnitterhebung fand online von Juni bis August 2020 statt und die Daten wurden über www.soscisurvey.de erhoben. Die schriftliche Befragung wurde unter Mitgliedern der Deutschen Gesellschaft für Public Health (DGPH) und des Ausschusses Digitalisierung der Gesellschaft für medizinische Ausbildung (GMA) und der Sektionen Bildung und Beratung der Deutschen Gesellschaft für Pflegewissenschaft (DGP) sowie der Arbeitsgruppe Lehre der Deutschen Gesellschaft für Medizinische Soziologie (DGMS) durchgeführt (n = 100).

Ergebnisse
Bei der Nutzung der digitalen Technologien in den Veranstaltungen rangieren auf der obersten Stelle Präsentationstools, gefolgt von Lernmanagementsystemen, Videoangeboten sowie digitalen Texten. Die Teilnehmenden geben hinsichtlich der Nutzung unterschiedliche (Konferenz‑)Tools an. Das Erstellen von Lehrvideos bejahen 53 % der Befragten, Abstimmungstools) werden bis > 50 % als unbekannt genannt. Als Herausforderungen werden digitale Infrastruktur der Hochschulen, fehlende didaktische Beratung/Unterstützung sowie rechtliche Fragen (Nutzungsrechte, Datenschutz) angegeben.

Schlussfolgerung
Neue Technologie werden vorwiegend für Wissenserwerb, Wissensvermittlung genutzt, selten zur Aktivierung von Studierenden und zur Gestaltung kollaborativer Lehr- und Lernarrangements sowie Neugestaltung von Lernaufgaben und Lernprozessen (individualisiertes Lernen). Welche der aktuell erprobten digitalen Lehr- und Lernformate zukünftig in der Hochschullehre zunehmend eingesetzt werden, hängt von vielen Faktoren ab, u. a. von digitaler Kompetenz sowie der Bereitschaft der Lehrenden und Lernenden die digitale Lernkultur mitzugestalten.
Serum TERT C228T is an important predictor of non-viral liver cancer with fatty liver disease
Authors: Akuta Norio , Kawamura Yusuke , Suzuki Fumitaka , Kobayashi Mariko , Arase Yasuji , Saitoh Satoshi , Muraishi Nozomu , Fujiyama Shunichiro , Sezaki Hitomi , Hosaka Tetsuya , Kobayashi Masahiro , Suzuki Yoshiyuki , Ikeda Kenji , Kumada Hiromitsu 
Published: March 2022

Abstract
Background
Molecular therapies and precision medicine are expected to be developed for liver cancer based on the diagnosis of DNA somatic alterations. However, it remains unclear whether TERT promoter mutation (TERT C228T) in serum cfDNA is useful for the diagnosis of liver cancer with non-viral fatty liver disease (FLD).

Methods
This retrospective cohort study examined 258 Japanese patients who had a confirmed diagnosis of primary liver cancer. We investigated the factors associated with TERT C228T and abnormal levels of liver cancer-specific tumor markers (AFP and PIVKAII) in serum samples.

Results
Multivariate analysis identified the etiology of FLD, vascular invasion, and non-cirrhosis as determinants of TERT C228T-positive liver cancer. Rates of positive TERT C228T in FLD were significantly higher than those of HBV and HCV. Conversely, rates of abnormal AFP in FLD were significantly lower than those of HBV and HCV. Viral suppression of HBV/HCV and alcohol intake did not affect TERT C228T, but AFP was significantly reduced by viral suppression. The rates of positive TERT C228T were significantly lower in HCV patients with viral clearance than those of FLD patients.

Conclusion
Our results highlight the importance of serum TERT C228T for the detection of non-viral FLD-related liver cancer. TERT C228T is a tumor marker that might not be influenced by inflammation.
How does subjective social status affect internalizing and externalizing problems among Syrian refugee adolescents?
Authors: Düren Rahşan , Yalçın Özgen 
Published: March 2022

Abstract
Although previous studies found the importance of community subjective social status for adolescent health, its relationship with mental health problems among refugee adolescents is unclear. To close this gap, we examined the nature of the relationship between subjective social status and externalizing problems in refugee adolescents. We carried out a cross-sectional study among three hundred and six 11–18-year-old Syrian refugee adolescents in Turkey. The measurements of the study were the MacArthur Scale of Subjective Social Status, Strengths and Difficulties Questionnaire (SDQ), the Depression Self Rating Scale for Children (DSRS-C), and the Spence Children’s Anxiety Scale (SCAS). The results supported the idea that adolescent’s community subjective social status may affect internalizing problems directly and externalizing problems indirectly via internalizing problems. The mediation effect of the internalizing problems on the relationship between subjective social status and externalizing problems were confirmed by three separate mediation models. The results were discussed in terms of previous literature.
Chemical looping reaction of methane with oxygen from La0.8Sr0.2FeO3-δ and La0.8Sr0.2FeO3-δ -Fe2O3 systems to syngas
Authors: Ohayon Dahan Hen , Sror Gal , Landau Miron V. , Herskowitz Moti 
Published: March 2022

AbstractThe reaction of methane with oxygen from La0.8Sr0.2FeO3-δ (LSF) and several LSF-Fe2O3 configurations was studied in chemical looping mode. Shell (LSF) and core (Fe2O3) (four catalysts called CS-3, CS-4, CS-5 and CS-6, over a range of coverage), LSF mixed uniformly with Fe2O3 (UM) and Fe2O3 (front) followed by LSF (PIS) were packed in a tubular reactor. The reaction was conducted at 900 °C and weight hourly space velocity (g methane/g catalyst/h) of 3 h−1 in 20 min reduction (10 mol% methane in nitrogen) and 20 min oxidation (10 mol% oxygen in nitrogen) cycles. LSF, CS, UM and PIS configurations yielded a significantly different performance (methane conversion, CO, CO2 and H2 selectivity and coke formation) measured in 10 reproducible cycles. The reaction and XRD data indicate that CO2 and steam formed by combustion of methane on Fe2O3 modify the phase composition of LSF, inhibits the initial LSF activity and improves the performance. Feeding a mixture containing 0.4 mol% CO2, 10 mol% methane in nitrogen to LSF confirms the positive effect of CO2 on the performance of LSF.
Non‐linear control of a boost PFC converter with a small inductor based on feedforward correction and frequency variation
Authors: Song Hongda , Liu Li , Yang Yang , Gong Yimin , Zhang ChenChen , Hao Zhengqiang , Hao Zhengjie , Zhang Jiannan 
Published: March 2022

AbstractTo reduce total harmonic distortion (THD) and improve the power factor (PF) of a boost power factor correction (PFC) converter, here, the authors propose a non‐linear control algorithm that includes the feedforward correction (FC) algorithm in the continuous conduction mode (CCM) and the non‐linear frequency variation (FV) algorithm in the mixed conduction mode (MCM). The proposed FC algorithm achieves current out of distortion through zero crossing with a lower current loop bandwidth. The proposed non‐linear FV algorithm achieves high PF and low THD under minimal load conditions. The non‐linear FV algorithm comprises a third harmonic extraction algorithm, a harmonic control loop for reducing THD and a frequency production algorithm. By using this non‐linear FV algorithm, the inductor size is reduced, which leads to lower cost and also achieves better THD and PF. The proposed algorithms are verified experimentally in terms of current tracking, current THD, PF, heating and loss on a 2000‐W boost PFC converter hardware prototype.
Anthropogenic light and noise affect the life histories of femaleGryllus veletisfield crickets
Authors: Rebar Darren , Bishop Corey , Hallett Allysa C 
Published: March 2022

AbstractAdaptive plasticity often offsets the negative effects of rapid environmental change. However, anthropogenic stressors like noise and artificial light at night (ALAN) are often unlike those environments experienced ancestrally, making the resulting responses of individuals potentially maladaptive or less predictable. Further uncertainty stems from few studies exploring how the two anthropogenic stressors may interact to influence individual responses. Here we reared female Gryllus veletis field crickets in traffic noise, ALAN, both, or neither to assess how each environment impacted their development, mating behaviors, and reproductive output. We first found that anthropogenic stressors influenced female development in three ways: those reared in ALAN took longer to reach adulthood, females reared in traffic noise were smaller as adults, and females reared in traffic noise lived longer than those reared in both anthropogenic stressors. We then documented pronounced effects on their behaviors and fitness. Females reared in noise in any capacity were more responsive to advertising males and mated with them faster, and females reared in any anthropogenic stressor retained spermatophores longer. Perhaps more significantly, any anthropogenic stressor reduced the lifetime fitness of females through reduced oviposition, hatching success, both, or reduced offspring size at hatching. However, we did not find decreased fitness of females reared with both anthropogenic stressors relative to those reared with just one. Our results highlight how novel anthropogenic stressors may impact populations, but whether individuals can adapt may depend on an interplay between development, mating behaviors, and reproductive output.