bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of the COVID-19 pandemic on the health behaviours of people living with and beyond breast, prostate, and colorectal cancer—a qualitative study
Authors: Buck Caroline , Pini Simon , Lally Phillippa , Beeken Rebecca J. , Fisher Abigail 
Published: July 2022

Abstract
Purpose
Positive health behaviours (sufficient exercise, healthy diet, limiting alcohol, and not smoking) can improve multiple outcomes after a cancer diagnosis. Observational studies suggest that health behaviours were negatively impacted for some but not all individuals living with and beyond cancer. The aim of this study was to qualitatively explore the impact of the pandemic on health behaviours of people in this population.

Methods
Thirty participants were purposively sampled for characteristics including diagnostic group (breast, prostate, and colorectal cancers), gender, time since diagnosis, and age. Semi-structured interviews were conducted to discuss the impact of the pandemic on health behaviours. Thematic analysis and a secondary Ideal Types analysis were conducted.

Results
Five themes covered changes in food, weight management, relationship to alcohol, and exercise. Five “types” were identified, representing orientations to health behaviours. The “gift of time” provided by the pandemic had an impact on health behaviours, with trends towards increases in drinking, eating unhealthy food, and exercising less.

Conclusions
The COVID-19 pandemic impacted engagement in positive health behaviours among participants in this study. Strict restrictions and changes in routines resulted in individuals adjusting how they managed their diet, alcohol intake, and exercise behaviours. The typology identified within this study helps to define how different orientation to health behaviours could underpin the responses of individual people LWBC.

Implications for cancer survivors
Alongside providing an understanding of the experiences of people LWBC during the COVID-19 pandemic, the proposed typology suggests how, with further development, future health behaviour interventions in this group could be targeted based on individual orientations to health, rather than demographic or clinical variables.
Variants of ERCC5 and the outcome of platinum-based regimens in non-small cell lung cancer: a prospective cohort study
Authors: Abdalkhalek Esraa S. , Wakeel Lamia M. El , Nagy Ahmed A. , Sabri Nagwa A. 
Published: July 2022

Abstract
Excision repair complementary complex 5 (ERCC5) is an important component in the repair pathway of platinum-induced damage. The current study evaluated the effect of ERCC5 variants (rs751402 and rs1047768) on the clinical outcome of platinum-based regimens in non-small cell lung cancer (NSCLC) patients. A prospective, cohort study was conducted on 57 newly diagnosed NSCLC Egyptian patients. Patients received either cisplatin or carboplatin-based chemotherapy. DNA was extracted and the variants were analyzed using real time PCR. This study found no significant difference between the studied variants and patients’ response to chemotherapy, progression-free survival (PFS) or overall survival (OS). However, a statistically significant association was found between the histologic subtypes and the studied variants (p = 0.028 and 0.018 for rs751402 and rs1047768, respectively). A statistically significant association was evident between the type of the allele present in the studied polymorphisms, p value = 0.000040. Moreover, the minor allele frequency (MAF) of the studied variants rs751402 and rs1047768 were similar to those of African and European populations, respectively. Results of this study have concluded that ERCC5 variants did not affect the clinical outcome of platinum-based chemotherapy in NSCLC. A significant coinheritance was found between the two variants of ERCC5. Moreover, the similarity between the MAF of the studied variants and the African or European population can guide future research when extrapolating data from African European populations to their Egyptian counterparts.
Shiny bronze in glassy matter: an inconspicuous piece of slag from the Bronze Age mining site of Mušiston (Tajikistan) and its significance for the development of tin metallurgy in Central Asia
Authors: Berger Daniel , Brügmann Gerhard , Friedrich Ronny , Lutz Joachim , Meyer Hans-Peter , Pernicka Ernst 
Published: July 2022

AbstractThis paper aims at contributing to a better understanding of the beginnings of tin and bronze metallurgy in Central Asia by investigating a hitherto unique piece of a bronze slag. The object was originally discovered as a stray find only 4 km away from the large copper-tin deposit of Mušiston in Tajikistan. It contains many prills of bronze and copper as well as small charcoal particles. Radiocarbon dating of the charcoal places the slag in a period between 1900 and 1400 BCE and thus in the Late Bronze Age of the region. This date coincides with radiocarbon dates of relics from underground galleries of the Mušiston deposit. Chemical and microscopic examination demonstrated the slag to be a relic of a co-smelting process, in which a natural assemblage of tin and copper minerals was smelted simultaneously. Both the chemical and the tin and copper isotope compositions clearly link the slag to the nearby polymetallic ores from Mušiston, of which an extensive dataset is presented. The artefact’s lead isotope ratios and increased iron concentration in turn indicate intentional fluxing of the original ore charge with iron-dominated ores. These results are the first tangible evidence of a smelting process of tin ores in the entire region and therefore add a new dimension to the findings from previous mining archaeological investigations. At the same time, the results give significant information about the smelting process of secondary polymetallic ores from Mušiston and help in assessing the scientific data of Bronze Age bronze artefacts from Central Asia.
Assessment of Surface Disinfection Effectiveness of Decontamination System COUNTERFOG® SDR-F05A+ Against Bacteriophage ɸ29
Authors: del Álamo Cristina , Vázquez-Calvo Ángela , Alcamí Antonio , Sánchez-García-Casarrubios Juan , Pérez-Díaz José Luis 
Published: July 2022

AbstractThe experience of COVID19 pandemic has demonstrated the real concern of biological agents dispersed in the air and surfaces environments. Therefore, the need of a fast and large-scale disinfection method has arisen for prevention of contagion. COUNTERFOG® is an innovative technology developed for large-scale decontamination of air and surfaces. The objective of this study is to assess experimentally the effectiveness of COUNTERFOG® in disinfecting viral-contaminated surfaces. We also aim to measure the necessary time to disinfect said surfaces. Stainless steel surfaces were contaminated with bacteriophage φ29 and disinfected using COUNTERFOG® SDR-F05A+, which uses a sodium hypochlorite solution at different concentrations and for different exposure times. A log reduction over 6 logs of virus titer is obtained in 1 min with 1.2% sodium hypochlorite when the application is direct; while at a radial distance of 5 cm from the point of application the disinfection reaches a reduction of 5.5 logs in 8 min. In the same way, a higher dilution of the sodium hypochlorite concentration (0.7% NaOCl) requires more exposure time (16 min) to obtain the same log reduction (> 6 logs). COUNTERFOG® creates, in a short time and at a distance of 2 m from the point of application, a thin layer of disinfectant that covers the surfaces. The selection of the concentration and exposure time is critical for the efficacy of disinfection. These tests demonstrate that a concentration between 0.7- 1.2% sodium hypochlorite is enough for a fast and efficient ɸ29 phage inactivation. The fact that ɸ29 phage is more resistant to disinfection than SARS-CoV-2 sustains this disinfection procedure.
Creating a reason to read: coaching strategies that support teachers to establish reading as a professional practice
Authors: Sawatzki Carly , Tour Ekaterina , Marangio Karen 
Published: July 2022

AbstractThe complex nature of teaching draws teachers to read so as to satisfy their curiosities, problem-solve and innovate. However, teachers find it challenging to access and learn from educational research findings. Through our work as ‘consultant coaches’ in one Australian school over the duration of one school year, we co-constructed strategies to support teachers in translating insights from professional reading in their classrooms. This article reports on how regular coach meetings provided a forum for professional discourse about successes and struggles that contributed to the generation of four interconnected strategies that supported teachers in making connections between educational research and their problems of practice. While experimenting with more sophisticated research-informed pedagogies sometimes produced tensions in the form of student resistance, persistence led to eventual success and tended to affirm for the majority of teachers that reading is a worthwhile professional activity. This, in turn, motivated teachers to continue reading. That coaches grew in their ability to encourage teachers to read and experiment is testament to the effectiveness of the coach meetings for supporting and extending their work as teacher educators.
Extended three step sixth order Jarratt-like methods under generalized conditions for nonlinear equations
Authors: Argyros Ioannis K. , Sharma Debasis , Argyros Christopher I. , Parhi Sanjaya Kumar , Sunanda Shanta Kumari , Argyros Michael I. 
Published: July 2022

AbstractThe convergence balls as well as the dynamical characteristics of two sixth order Jarratt-like methods (JLM1 and JLM2) are compared. First, the ball analysis theorems for these algorithms are proved by applying generalized Lipschitz conditions on derivative of the first order. As a result, significant information on the radii of convergence and the regions of uniqueness for the solution are found along with calculable error distances. Also, the scope of utilization of these algorithms is extended. Then, we compare the dynamical properties, using the attraction basin approach, of these iterative schemes. At the end, standard application problems are considered to demonstrate the efficacy of our theoretical findings on ball convergence. For these problems, the convergence balls are computed and compared. From these comparisons, it is confirmed that JLM1 has the bigger convergence balls than JLM2. Also, the attraction basins for JLM1 are larger in comparison to JLM2. Thus, for numerical applications, JLM1 is better than JLM2.
Determining Seismic Bearing Capacity of Footings Embedded in Cohesive Soil Slopes Using Multivariate Adaptive Regression Splines
Authors: Lai Van Qui , Lai Fengwen , Yang Dayu , Shiau Jim , Yodsomjai Wittawat , Keawsawasvong Suraparb 
Published: July 2022

AbstractSeismic bearing capacity of strip footings in cohesive soil slopes considering various embedded depths is investigated in this study. Novel solutions using pseudo-static method and finite element limit analysis (FELA) with upper bound (LB) and lower bound (LB) theorems are presented. The influences of footing depth, slope angle, slope height, undrained shear strength and pseudo-static acceleration on bearing capacity and failure mechanisms are examined using dimensionless parameters. With the comprehensive numerical results, the multivariate adaptive regression splines (MARS) model is then utilized to simulate the sensitivity of all dimensionless input parameters (i.e., the normalized depth of footing D/B, the normalized slope height H/B, the normalized distance from top slope to edge of the footing L/B, slope angle β, the strength ratio cu/γB, and the pseudo-static acceleration factor, kh). The degree of influence of each design parameter is produced, and an empirical equation for the dimensionless output parameter (i.e., bearing capacity factor Nc) is proposed. The study results are accessible in the design charts, tables, empirical equation for design practitioners.
Building from Patient Experiences to Deliver Patient-Focused Healthcare Systems in Collaboration with Patients: A Call to Action
Authors: Schroeder Karlin , Bertelsen Neil , Scott Jessica , Deane Katherine , Dormer Laura , Nair Devika , Elliott Jim , Krug Sarah , Sargeant Ify , Chapman Hayley , Brooke Nicholas 
Published: July 2022

AbstractPatients’ experiences of their diagnosis, condition, and treatment (including the impact on their lives), and their experiences surrounding expectations of care, are becoming increasingly important in shaping healthcare systems that meet the evolving needs and priorities of different patient communities over time; this is an ongoing goal of all healthcare stakeholders. Current approaches that capture patient experiences with data are fragmented, resulting in duplication of effort, numerous requests for information, and increased patient burden. Application of patient experience data to inform healthcare decisions is still emerging and there remains an opportunity to align diverse stakeholders on the value of these data to strengthen healthcare systems. Given the collective value of understanding patient experiences across multiple stakeholder groups, we propose a more aligned approach to the collection of patient experience data. This approach is built on the principle that the patients’ experiences are the starting point, and not just something to be considered at the end of the process. It must also be based on meaningful patient engagement, where patients are collaborators and decision makers at each step, thereby ensuring their needs and priorities are accurately reflected. The resulting data and evidence should be made available for all stakeholders, to inform their decision making and healthcare strategies in ways that meet patient priorities. We call for multi-stakeholder collaboration that will deliver healthcare systems and interventions that are better centered around and tailored to patient experiences, and that will help address patients’ unmet needs.
Challenges in modeling the energy balance and melt in the percolation zone of the Greenland ice sheet
Authors: Covi Federico , Hock Regine , Reijmer Carleen H. 
Published: July 2022

AbstractIncreased surface melt in the percolation zone of the Greenland ice sheet causes significant changes in the firn structure, directly affecting the amount and timing of meltwater runoff. Here we force an energy-balance model with automatic weather stations data at two sites in the percolation zone of southwest Greenland ($2040$ and 2360 m a.s.l.) between spring $2017$ and fall $2019$. Extensive model validation and sensitivity analysis reveal that the skin layer formulation used to compute the surface temperature by closing the energy balance leads to a consistent overestimation of melt by more than a factor of two or three depending on the site. In contrast, model results match the observations well when the model is forced by observed surface temperatures; however, unexplained residuals in the energy balance occur. The sensible and ground heat flux differ markedly in the two simulations accounting largely for the difference in modeled melt amounts. This indicates that the energy available for melt is highly sensitive to small changes in surface temperature. Thus, regional climate models that also use the skin layer formulation may have a bias in surface temperature and melt energy in the percolation zone of the ice sheet.
Application of visual stratigraphy from line-scan images to constrain chronology and melt features of a firn core from coastal Antarctica
Authors: Dey Rahul , Thamban Meloth , Laluraj Chavarukonam Madhavanpillai , Mahalinganathan Kanthanathan , Redkar Bhikaji Laxman , Kumar Sudhir , Matsuoka Kenichi 
Published: July 2022

AbstractEstablishing an accurate chronology is crucial for interpretation of ice core-based climatic records. While high snow accumulation rates characterise coastal Antarctica, thus enabling recovery of highly resolved climatic records, summertime melting at such low-elevation sites offers challenges in establishing a reliable chronological framework through traditional approaches using the seasonality of stable water isotope and ionic proxy records. Here, we assess visual stratigraphy (VS) obtained from line-scan images as a proxy for annual layer counting in firn section (top 50 m) of the IND-36/B9 ice core (dated 1919–2016 CE) from the Djupranen Ice Rise in central Dronning Maud Land, East Antarctica. We also used these images to obtain melt history for the site and found that traditional thickness-based quantification of melt proportion results in significant overestimations. Since density has dominant control on VS profile over the firn section, we first used circulant single-spectrum analysis to remove the secular trend and then we extracted the seasonal VS signals attributed to dust and sea-salt inclusions. We find that melt layers do not significantly alter the VS records if masked during pre-processing. The age–depth model based on the reconstructed VS profile revealed an excellent match with identified time-markers within an uncertainty of ±2 years.
Detecting Streamflow in Dryland Rivers Using CubeSats
Authors: Wang Zhaocheng , Vivoni Enrique R. 
Published: July 2022

AbstractDetermining the flow regime of non‐perennial rivers is critical in hydrology. In this study, we developed a new approach using CubeSat imagery to detect streamflow presence using differences in surface reflectance for areas within and outside of a river reach. We calibrated the approach with streamflow records in the Hassayampa River of Arizona over 3 years (2019–2021), finding good agreement in the annual fractions of flowing days at stream gages (R2 = 0.82, p < 0.0001). Subsequently, annual fractions of flowing days were derived at 90 m intervals along the Hassayampa River, finding that 12% of reaches were classified as intermittent, with the remaining as ephemeral. Using a Hovmöller diagram, streamflow presence was visualized in unprecedented spatiotemporal detail, allowing estimates of daily fraction of flowing channel and annual fractions of flowing days. This new tool opens avenues for detecting streamflow and studying hydrological and biogeochemical processes dependent on water presence in drylands.
Generation of a Strong Parallel Electric Field and Embedded Electron Jet in the Exhaust of Moderate Guide Field Reconnection
Authors: Wetherton Blake A. , Egedal Jan , Le Ari , Daughton William 
Published: July 2022

AbstractMagnetospheric Multiscale observed an extended current layer concurrent with a strong parallel electric field. The current layer is embedded in the reconnection exhaust and is consistent with an extended magnetized jet expected in roughly symmetric moderate guide field reconnection. The strong parallel electric field observed at the jet balances a strong gradient in the parallel electron pressure caused by a transition between magnetized electrons with Te‖ > Te⊥ on one side of the jet and demagnetized, roughly isotropic electrons across the thin current layer. Simulation results show how this transition can occur and how the associated electron pressure gradients in Ohm's law balance the parallel electric field.
Multifrequency Observations of Postmidnight Ionospheric Irregularities From an Anomaly Crest Location
Authors: Goswami Samiddha , Ghosh Sayani , Paul Ashik 
Published: July 2022

AbstractThe paper reports occurrences of postmidnight to early morning ionospheric depletions in total electron content (TEC) observed using the Low Earth Orbiting satellite beacon from Calcutta (22.57°N, 88.36°E geographic, and 32°N magnetic dip) situated around the northern crest of the equatorial ionization anomaly (EIA) in the Indian longitude sector for the period 2015–2016. These results are novel and contrary to the usual scenario of equatorial ionospheric irregularities being dominant during the early evening to pre‐midnight hours of equinoctial months. The TEC depletions, commonly called “bite‐outs,” exhibit amplitudes of 1–2.5 TECU, with maximum depletion found near the northern crest of the EIA around subionospheric coordinates 25.8°N and 82.2°E. These bite‐outs exhibited seasonal variabilities, with maximum occurrences found during local summer months. The observed TEC depletions during postmidnight hours point toward irregularities, which are not generated over the magnetic equator and drifted along magnetic field lines. A case study of the observation of these ionospheric disturbances has also been presented across a spectrum of frequencies, namely 150 and 400 MHz (Low Earth Orbit satellites), 250 MHz (Geostationary satellites), and 1.5 GHz (GPS—Medium Earth Orbit satellites) to establish the presence of irregularities of different scale sizes even during postmidnight hours.
Cancer cells corrupt normal epithelial cells through miR-let-7c-rich small extracellular vesicle-mediated downregulation of p53/PTEN
Authors: Liang Weilian , Chen Yang , Liu Hanzhe , Zhao Hui , Luo Tingting , Tang Hokeung , Zhou Xiaocheng , Jiang Erhui , Shao Zhe , Liu Ke , Shang Zhengjun 
Published: July 2022

AbstractTumor volume increases continuously in the advanced stage, and aside from the self-renewal of tumor cells, whether the oncogenic transformation of surrounding normal cells is involved in this process is currently unclear. Here, we show that oral squamous cell carcinoma (OSCC)-derived small extracellular vesicles (sEVs) promote the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of normal epithelial cells but delay their apoptosis. In addition, nuclear-cytoplasmic invaginations and multiple nucleoli are observed in sEV-treated normal cells, both of which are typical characteristics of premalignant lesions of OSCC. Mechanistically, miR-let-7c in OSCC-derived sEVs is transferred to normal epithelial cells, leading to the transcriptional inhibition of p53 and inactivation of the p53/PTEN pathway. In summary, we demonstrate that OSCC-derived sEVs promote the precancerous transformation of normal epithelial cells, in which the miR-let-7c/p53/PTEN pathway plays an important role. Our findings reveal that cancer cells can corrupt normal epithelial cells through sEVs, which provides new insight into the progression of OSCC.