bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soil science challenges—An interdisciplinary overview of current and future topics
Authors: Pohl Lydia , Maurischat Philipp , Schiedung Marcus , Weber Tobias K. D. , Winkler Pauline 
Published: November 2022

AbstractThis editorial was written by early career scientists in soil science and gives an overview of the articles published in the special issue “Soil Science Challenges—An Interdisciplinary Overview of Current and Future Topics” on the occasion of the 100th anniversary of Journal of Plant Nutrition and Soil Science. A broad range of articles addressing soil carbon dynamics from the microscale to landscape scale, multi‐dimensional modeling, improved land management practices, nutrient cycles, soil hydrology, plastic in soils, and interdisciplinarity of soil science is covered in this issue.
Impact of adjuvant therapy on outcomes after curative‐intent resection for distal cholangiocarcinoma
Authors: Hou Jing‐Jing , Maithel Shishir K. , Weber Sharon M. , Poultsides George , Wolfgang Christopher L. , Fields Ryan C. , He Jin , Scoggins Charles , Idrees Kamron , Shen Perry , Zhang Xu‐Feng , Pawlik Timothy M. 
Published: November 2022

AbstractBackgroundThe benefit of adjuvant therapy (AT) after curative resection of distal cholangiocarcinoma (DCC) remains unclear. The objective of the current study was to investigate the impact of AT on long‐term survival of patients who underwent curative‐intent resection for DCC.MethodsPatients who underwent curative‐intent resection for DCC between 2000 and 2020 were identified from a multi‐institutional database. The primary outcomes included overall (OS) and recurrence‐free survival (RFS).ResultsAmong 245 patients, 150 (61.2%) patients received AT (chemotherapy alone: n = 43; chemo‐ and radiotherapy: n = 107) after surgical resection, whereas 95 (38.8%) patients underwent surgery only. Patients who received AT were younger, and more likely to have an advanced tumor with the presence of perineural invasion (PNI), lymph node metastasis (LNM), lymph‐vascular invasion, and higher T categories (all p < 0.05). Overall, there was no difference in OS (median, surgery + AT 25.5 vs. surgery alone 24.5 months, p = 0.27) or RFS (median, surgery + AT 15.8 vs. surgery alone 18.9 months, p = 0.24) among patients who did versus did not receive AT. In contrast, AT was associated with improved long‐term survival among patients with PNI (median OS, surgery + AT 25.9 vs. surgery alone 17.8 months, p = 0.03; median RFS, surgery + AT 15.9 vs. surgery alone 11.9 months, p = 0.04) and LNM (median, surgery + AT 20.0 vs. surgery alone 17.8 months, p = 0.03), but not among patients with no PNI or LNM (all p > 0.1).ConclusionsAT was commonly utilized among patients with DCC. Patients with more advanced disease, including the presence of PNI or LNM, benefited the most from AT with improved long‐term outcomes among this subset of patients.
Analysis and Comparison of the Malignant Thyroid Nodules Not Recommended for Biopsy in ACR TIRADS and AI TIRADS With a Large Sample of Surgical Series
Authors: Cui Yiyang , Fu Chao , Si Caifeng , Li Jing , Kang Yaning , Huang Yuanjing , Cui Kefei 
Published: November 2022

ObjectiveTo determine if the artificial intelligence‐based Thyroid Imaging, Reporting and Data System (AI TIRADS) would perform better than the American College of Radiology (ACR) TIRADS in monitoring malignant thyroid nodules not recommended for biopsy using follow‐up thresholds.MethodsA total of 3499 thyroid nodules with surgical histopathology and ultrasound features were retrospectively reviewed and categorized using ACR TIRADS and AI TIRADS. The recommendations for biopsy and follow‐up divided nodules into three groups 1) fine needle aspiration (FNA), 2) follow‐up ultrasound, and 3) no further evaluation.ResultsOf the total 1608 malignant nodules in this study, 974 malignant nodules would not be biopsied in ACR TIRADS compared with 967 in AI TIRADS. While 60.0% (584/974) of these non‐biopsied malignancies could be followed‐up by ultrasound in ACR TIRADS and 62.8% (607/967) in AI TIRADS. For the malignancies of no further evaluation, 97.4% (380/390) were sized <10 mm in ACR TIRADS and 93.3% (336/360) in AI TIRADS. Compared with ACR TIRADS, AI TIRADS had lower unnecessary FNA rate and missing cancer rate (41.0% vs 47.8% and 22.8% vs 27.5%, P < .05, respectively) while having higher specificity and AUC as well as lower sensitivity (65.0% vs 57.9%, 0.895 vs 0.881, and 96.1% vs 97.8%, all P < .05).ConclusionsUsing the follow‐up thresholds, more than half of the malignancies not being biopsied were monitored by ultrasound in both ACR TIRADS and AI TIRADS, and AI TIRADS had lower missing cancer rate. More than 90% of malignancies recommended for no further evaluation were <10 mm in diameter.
Development of an interdisciplinary microtia‐atresia care model: A single‐center 20‐year experience
Authors: Patel Krupa R. , Benchetrit Liliya , Ronner Evette A. , Occhiogrosso Jessica , Hadlock Tessa , Shaye David , Quesnel Alicia M. , Cohen Michael S. 
Published: November 2022

AbstractObjectivesMicrotia and aural atresia are congenital ear anomalies with a wide‐ranging spectrum of phenotypes and varied functional and psychosocial consequences for patients. This study seeks to analyze the management of microtia‐atresia patients at our center over a 20‐year period and to propose recommendations for advancing microtia‐atresia care at a national level.MethodsWe performed a retrospective analysis of data from patients presenting to the Massachusetts Eye and Ear (Boston, MA) for initial otolaryngology consultation for congenital microtia and/or aural atresia between 1999 and 2018.ResultsOver the 20‐year study period, 229 patients presented to our microtia‐atresia center at a median age of 7 years. The severity of microtia was most commonly classified as grade III (n = 87, 38%), 61% (n = 140) of patients had complete atresia, the median Jahrsdoerfer grading scale score was 6 (range 0–10), and 81 patients (35%) underwent surgery for microtia repair. For hearing rehabilitation, 30 patients (64%) underwent bone conduction device implantation and 17 patients (36%) underwent atresiaplasty. The implementation of an interdisciplinary, longitudinal care model resulted in an increase in patient (r = 0.819, p < .001) and surgical volume (microtia surgeries, r = 0.521, p = .019; otologic surgeries, r = 0.767, p < .001) at our center over time.ConclusionAn interdisciplinary team approach to microtia‐atresia patient care may result in increased patient volume, which could improve aesthetic and hearing outcomes over time by concentrating care and surgical expertise. Future work should aim to establish standardized clinical consensus recommendations to guide the creation of high‐quality microtia‐atresia care programs.Level of Evidence4.
Poly(oxanorbornene)‐Based Polyzwitterions with Systematically Increasing Hydrophobicity: Synthesis, Physical Characterization, and Biological Properties
Authors: Paschke Stefan , Marx Franziska , Bleicher Vera , Eickenscheidt Alice , Lienkamp Karen 
Published: November 2022

AbstractSurfaces coated with polyzwitterions are known to resist protein adhesion and to be generally bio‐inert. In recent reports, several polyzwitterionic coatings with carboxylate groups and intrinsic antimicrobial activity due to the pH‐responsivity of that group are described, but the design rules to obtain such activity remain unclear. Therefore, in this work, a set of surface‐attached polyzwitterions with carboxylate groups and varying alkyl residues is studied. The gradually increasing hydrophobicity of these surfaces (verified by contact angle and swellability measurements) has an impact on their biological properties. Hydrophilic surfaces (polyzwitterions bearing short alkyl residues) behave like “classical” polyzwitterions: they repel proteins and human cells and are non‐toxic to bacteria. The more hydrophobic polyzwitterionic surfaces are protein‐adhesive, cell‐toxic, and can kill bacteria. This indicates that the hydrophobicity of polyzwitterionic surfaces needs to be balanced precisely to combine protein‐repellency and antimicrobial activity in a single material.
Templated Synthesis of 2D Polyimide Covalent Organic Framework for Rechargeable Sodium‐Ion Batteries
Authors: Shehab Mohammad K. , Weeraratne K. Shamara , El‐Kadri Oussama M. , Yadavalli Vamsi K. , El‐Kaderi Hani M. 
Published: November 2022

AbstractCovalent organic frameworks (COFs) hold great promise for electrochemical energy storage because of their high surface area, readily accessible redox‐active sites, and environment‐friendly chemical composition. In this study, the synthesis of a redox‐active pyrene‐containing polyimide COF (PICOF‐1) by linker exchange using an imine‐linked COF as a template is reported and its performance in sodium‐ion batteries (SIBs) is demonstrated. The reported synthetic route based on linker exchange mitigates the challenges typically encountered with crystallizing chemically stable polyimide COFs from typical condensation reactions; thus, facilitating their rapid synthesis and purification. Using this approach, PICOF‐1 exhibits high crystallinity with very low refinement parameters RP and RWP of 0.415% and 0.326%, respectively. PICOF‐1 has a high Brunauer–Emmette–Teller (BET) surface area of 924 m2 g−1 and well‐defined one‐dimentional (1D) channels of 2.46 × 1.90 nm, which enable fast ion transport and charge transfer, reaching a capacity at 0.1 C of almost nearly as its theoretical capacity and maintaining 99% Coulombic efficiency over 175 cycles at 0.3 C. The study demonstrates that imine‐linked COFs are effective templates for integrating carbonyl‐rich polyimide moieties into high‐surface COFs to advance electrochemical energy storage applications.
Impact of terminal tip location of midline catheters on catheter‐related complications and indwelling duration in elderly patients
Authors: Fu Jing , Zhao Lingling , Tian Yingmei , Liu Yinmeng , Zhang Hongyu , Li Haijun 
Published: November 2022

AbstractAimTo investigate the relationship between the position of the midline catheter tip and the frequency and type of complications associated with its placement.DesignA cohort study was performed on patients between May 2018 and December 2021 who underwent midline catheter placement at our institution. Patients were divided into two groups, superficial implementation and deep implementation, based on the midline catheter tip location relative to the clavicle.MethodsClinical data and outcome parameters, including the numbers and types of midline catheter‐related complications, day of occurrence and catheter indwell duration, were recorded.ResultsCatheter‐related complications occurred in 14 individuals. Compared with the superficial implementation group, the incidence of complications in the deep catheterization group was significantly reduced, with a delayed first occurrence time, and a prolonged catheter indwelling time. The results suggested that locating the midline catheter tip in the distal segment of the axillary vein may reduce catheter‐related complication incidence and prolong the indwelling duration.
Development of resistance to FGFR inhibition in urothelial carcinoma via multiple pathways in vitro
Authors: Pettitt Geoffrey A , Hurst Carolyn D , Khan Zubeda , McPherson Helen R , Dunning Matthew C , Alder Olivia , Platt Fiona M , Black Emma VI , Burns Julie E , Knowles Margaret A 
Published: November 2022

AbstractAlterations of fibroblast growth factor receptors (FGFRs) are common in bladder and other cancers and result in disrupted signalling via several pathways. Therapeutics that target FGFRs have now entered the clinic, but, in common with many cancer therapies, resistance develops in most cases. To model this, we derived resistant sublines of two FGFR‐driven bladder cancer cell lines by long‐term culture with the FGFR inhibitor PD173074 and explored mechanisms using expression profiling and whole‐exome sequencing. We identified several resistance‐associated molecular profiles. These included HRAS mutation in one case and reversible mechanisms resembling a drug‐tolerant persister phenotype in others. Upregulated IGF1R expression in one resistant derivative was associated with sensitivity to linsitinib and a profile with upregulation of a YAP/TAZ signature to sensitivity to the YAP inhibitor CA3 in another. However, upregulation of other potential therapeutic targets was not indicative of sensitivity. Overall, the heterogeneity in resistance mechanisms and commonality of the persister state present a considerable challenge for personalised therapy. Nevertheless, the reversibility of resistance may indicate a benefit from treatment interruptions or retreatment following disease relapse in some patients. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
An introduction to causal inference for pharmacometricians
Authors: Rogers James A. , Maas Hugo , Pitarch Alejandro Pérez 
Published: November 2022

AbstractAs formal causal inference begins to play a greater role in disciplines that intersect with pharmacometrics, such as biostatistics, epidemiology, and artificial intelligence/machine learning, pharmacometricians may increasingly benefit from a basic fluency in foundational causal inference concepts. This tutorial seeks to orient pharmacometricians to three such fundamental concepts: potential outcomes, g‐formula, and directed acyclic graphs (DAGs).
SH2 Domain-Containing Protein Tyrosine Phosphatase-2 is Enriched in Eyelid Specimens of Rosacea
Authors: Chebolu Apoorv , Ramos Ramon Bossardi , Arunachalam Thilaka , Adam Alejandro Pablo , Wladis Edward J. 
Published: November 2022

Abstract

Background
Rosacea is a cutaneous disease that may secondarily affect the ocular surface. Due to the vision threatening, cosmetic, psychological, and work productivity impact, the identification of cellular targets that govern rosacea would enhance our understanding of the biology of the disease and delineate targets for therapeutic manipulation.

Objective
To characterize the involvement of SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) in the pathogenesis of rosacea.

Methods
Specimens from elective ectropion surgery (n = 20) were processed from patients with rosacea (n = 10) and control patients (n = 10). Immunohistochemistry (IHC) and quantitative western blotting (WB) were performed to identify and quantify the presence of SHP2 and 4G10 (a phosphotyrosine antibody) in rosacea compared to normal tissue. IHC samples were graded according to an intensity scale (0–4). Mann-Whitney statistical analyses were performed via a dedicated computerized software package.

Results
On WB, SHP2 was expressed in higher concentrations in rosacea specimens (p &lt; 0.05). On IHC, SHP2 was enriched in the epidermis in rosacea (p &lt; 0.05), although 4G10 levels were not statistically significantly different between the two groups (p &gt; 0.05).

Conclusions
SHP2 is enriched in cutaneous specimens of rosacea, suggesting a critical role for this protein in the disease and indicating a modifiable therapeutic moiety.
A Phthalocyanine with an Olefin at Its Center as PotentialG‐Quadruplex Ligand
Authors: Petroselli Manuel 
Published: November 2022

AbstractWe report the synthesis of a polycyclic dicationic phthalocyanine through N‐functionalization of the internal core with an olefin (C=C) and compared with its porphyrin analogues. Potential application of this new class of molecules as G‐quadruplex (G4)‐targeting ligand has been investigated by computational point of view, showing encouraging results with respect to the current benchmarks.
Preparation and Characterization of PAM‐b‐DOPOAA by ATRP
Authors: Wang Yazhen , Yang Qing , Zu Liwu , Dong Shaobo , Lan Tianyu 
Published: November 2022

AbstractPolyacrylamide has been a hot topic of research in recent years, however, the preparation of block copolymers of polyacrylamide using ATRP method has been little studied. In this paper, polyacrylamide with reactive group bromine (PAM−Br) was synthesized by atom transfer radical polymerization (ATRP) using acrylamide (AM) as the monomer and water as the solvent, and polyacrylamide was used as the macromolecular initiator for the next reaction step. Then 9,10‐dihydro‐9‐oxa‐10‐phosphafi‐10‐oxide (DOPO) was organically modified to obtain acrylate monomers with DOPO functional groups (DOPOAA), and a mixture of water and N, N‐dimethylformamide (DMF) was used as the solvent to obtain PAM‐b‐DOPOAA block copolymers with controllable molecular mass and narrow molecular mass distribution. The effects of the molecular mass of the macromolecular initiator, polymerization time, and the molar ratio of catalyst to the ligand on the polymerization process were investigated. The structure and properties of the products were also characterized by 1H‐NMR, FTIR, XPS, DSC, TG, etc. The PAM‐b‐DOPOAA prepared by ATRP method can artificially design the length and ratio of the two chain segments, realizing one additive with two functions and the permanent existence of the function of polymer additives.
Role of External Electric Field in Carrier Mobility of Graphene/ZnO Heterojunction Adsorbed H2O and O2 Molecules
Authors: Jin Yanxin , Ding Jijun , Yang Mingya , Chen Haixia 
Published: November 2022

AbstractThe density functional theory is performed to investigate the energy band structure, effective mass and carrier mobility of Graphene/ZnO (G/ZnO) heterojunction. The intrinsic G/ZnO heterojunction has higher electron mobility (4.323 m2/V⋅s) as compared to Graphene and ZnO. The adsorption of H2O and O2 molecules significantly reduces the carrier mobility of the G/ZnO heterojunction. Then, the number of H2O and O2 molecules is changed from 1 to 4. The results show that electron mobility of the G/ZnO heterojunction increase with increasing number of H2O, but the opposite is true for O2. Therefore, both strain and external electric field (Eext) are used to regulate the electronic properties. The carrier mobility are significantly enhanced under appropriate Eext. In this work, under the strain and Eext, the calculation about the adsorption of H2O and O2 will play an important role in monitoring the stability of G/ZnO heterojunction based microelectronic devices in the external environment.
Cobalt Doped Sulfonated Polyaniline with High Electrocatalytic Activity and Stability for Oxygen Evolution Reaction
Authors: Vijayarangan Murugan , Mathi Selvam , Gayathri Arunagiri , Jayabarathi Jayaraman , Thanikachalam Venugopal 
Published: November 2022

AbstractThe oxygen (OER) evolution reaction plays a crucial role for storage of renewable energy sources but, active sites of the active electrocatalysis remain in challengeable. In this work, we have developed sulfonated polyaniline (SPANI) coordinated with Co sites to investigate the OER process. To improve the electrical conductivity and electrocatalytic efficiency towards OER herein, we report Co@SPANI synthesized by solvothermal method. The different physical characterization (SEM, TEM, XRD, IR, XPS and UV‐DRS) and electrochemical methods (voltammetry, chronopotentiometry and EIS) have been used to characterize Co@SPANI materials and examined the correlation of materials with activity. The cobalt doped SPANI (Co@SPANI‐800) exhibits higher electrocatalytic activity, showing smaller Tafel slope of 167 mV dec−1 with lower overpotential of 312 mV at 10 mA cm−2 in 1 M KOH, which reveal that abundant Co‐metal sites remarkably supporting the OER activity. Co@SPANI‐800 exhibits exceptional OER performances and durability over 200 h with loss of <3.5 % in alkaline medium. At 1.54 V, solar powered water electrolysis confirmed the effectiveness of newborn electrocatalyst in solar energy to hydrogen energy conversion. Therefore, this work offered new path for designing materials as self‐supporting electrode for water splitting and for other potential applications.
Cu(I)‐Catalyzed One‐Pot Synthesis of [1,2,3]Triazolo[5,1‐a] isoquinolin‐6(5H)‐one Derivatives as EGFR‐Targeting Anticancer Agents
Authors: Samala Rajkumar , Kumar Nukala Satheesh , Swamy Thirukovela Narasimha , Reddy Nagavelli Vasudeva , Narsimha Sirassu 
Published: November 2022

AbstractThe CuI promoted one‐pot multi‐component synthesis of new fused [1,2,3]triazolo[5,1‐a]isoquinoline derivatives (4 a–4 h, 8 a–8 f & 9 a–9 f) without isolating unsafe azides and their in vitro cytotoxic activity against MCF‐7 & MDA‐MB‐231 (breast cancer cells) and A‐549 (alveolar carcinoma) was reported herein. Out of all, compounds 9‐chloro‐1‐(morpholinomethyl)‐[1,2,3]triazolo[5,1‐a]isoquinolin‐6(5H)‐one (8 d), 9‐fluoro‐1‐(morpholinomethyl)‐[1,2,3]triazolo[5,1‐a]isoquinolin‐6(5H)‐one (8 e), 9‐chloro‐1‐((1,1‐dioxidothiomorpholino)methyl)‐[1,2,3]triazolo[5,1‐a]isoquinolin‐6(5H)‐one (9 d), and 1‐((1,1‐dioxidothiomorpholino)methyl)‐9‐fluoro‐[1,2,3]triazolo[5,1‐a]isoquinolin‐6(5H)‐one (9 e) showed superior potency against all the cell lines than the standard drug erlotinib with IC50 values ranging from 2.45 to 7.19 μM. The most active compounds 8 d, 8 e, 9 d, and 9 e were also screened for their efficacy in inhibiting tyrosine kinase EGFR and results revealed that compound 9 d showed comparable activity with standard drug erlotinib, whereas, compounds 8 d, 8 e, and 9 e showed superior activity than the erlotinib. Molecular modeling studies for active compounds on EGFR (PDB‐ID‐4HJO) were also conducted and the obtained free energies were observed to be in agreement with the in vitro activity data. Finally, compounds 8 d, 8 e, 9 d, and 9 e didn't show AMES toxicity and followed the rules of Egan, Ghose, Veber, Lipinski, and Muegge rules without any deviation.
Bioinspired Dual‐Mode Stretchable Strain Sensor Based on Magnetic Nanocomposites for Strain/Magnetic Discrimination
Authors: Guo Xiaohui , Hong Weiqiang , Zhao Yunong , Zhu Tong , Liu Long , Li Hongjin , Wang Ziwei , Wang Dandan , Mai Zhihong , Zhang Tianxu , Yang Jinyang , Zhang Fengzhe , Xia Yun , Hong Qi , Xu Yaohua , Yan Feng , Wang Ming , Xing Guozhong 
Published: November 2022

AbstractRecently, flexible stretchable sensors have been gaining attention for their excellent adaptability for electronic skin applications. However, the preparation of stretchable strain sensors that achieve dual‐mode sensing while still retaining ultra‐low detection limit of strain, high sensitivity, and low cost is a pressing task. Herein, a high‐performance dual‐mode stretchable strain sensor (DMSSS) based on biomimetic scorpion foot slit microstructures and multi‐walled carbon nanotubes (MWCNTs)/graphene (GR)/silicone rubber (SR)/Fe3O4 nanocomposites is proposed, which can accurately sense strain and magnetic stimuli. The DMSSS exhibits a large strain detection range (≈160%), sensitivity up to 100.56 (130–160%), an ultra‐low detection limit of strain (0.16% strain), and superior durability (9000 cycles of stretch/release). The sensor can accurately recognize sign language movement, as well as realize object proximity information perception and whole process information monitoring. Furthermore, human joint movements and micro‐expressions can be monitored in real‐time. Therefore, the DMSSS of this work opens up promising prospects for applications in sign language pose recognition, non‐contact sensing, human‐computer interaction, and electronic skin.