bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multi-Centric Study Assessing Safety and Efficacy of Everolimus in Adult Chinese Patients With Tuberous Sclerosis Complex Associated Renal Angiomyolipomas
Authors: Wang Wenda , Guo Gang , Shi Guohai , Wei Xin , Hu Zhiquan , Li Hanzhong , Zhang Xu , Ye Dingwei , Zhang Yushi 
Published: July 2022

BackgroundEverolimus has been approved in China for adult patients with TSC-AML (tuberous sclerosis associated renal angiomyolipomas) not requiring immediate surgery and has been previously shown to be an effective treatment option for TSC-AML in the Chinese populationMethodsThis is an open label, single arm, multi-center Phase IV post-approval commitment study to further assess the safety and efficacy of everolimus in patients with TSC-AML who do not require immediate surgical intervention. The primary outcome was to evaluate the safety of everolimus while the secondary outcome was to evaluate AML response.ResultsTreatment with everolimus was associated with a clinically meaningful best overall AML response rate of 70% (95% CI: 53.5, 83.4). Of the 38 evaluable patients, 37 (97%) patients experienced a reduction in the sum of volumes of target angiomyolipoma lesions relative to baseline. At Week 12 (n=38), the median percentage change in sum of target AML volume was −56.60%, which further changed by -59.96% at Week 24 (n=38), and by −64.41% at Week 48 (n=22). Throughout the study, renal function remained relatively stable. Patients with TSC associated lymphangiomyomatosis (LAM) (N=13) demonstrated a lower than expected rate of decline in pulmonary function tests (PFTs). Everolimus was generally well tolerated with no significant safety findings in Chinese patients. Most of the adverse events were of grade 1-2, and manageable with appropriate dose adjustments and supportive therapies. There were no treatment discontinuation due to AE and no treatment death was reported.ConclusionsBased on the efficacy and safety data presented in this study, the overall clinical benefit/risk assessment further supports the use of everolimus as a viable treatment option for Chinese patients with TSC-AML.
Accuracy and Reliability of Whole Blood Bilirubin Measurements Using a Roche Blood Gas Analyzer for Neonatal Hyperbilirubinemia Screening and Risk Stratification
Authors: Wang Qing , Zhang Tianyi , Lin Yuanxi , Jiang Li , Zhou Wenlong , Zong Xiaolong 
Published: July 2022

BackgroundAccurate bilirubin measurements are essential for appropriate management of neonatal hyperbilirubinemia. This study aimed to evaluate the accuracy and reliability of whole blood bilirubin measurements obtained using a Roche blood gas analyzer (Roche TBiL), with total serum bilirubin (TSB) measurements determined by the Ortho VITROS 4600 chemistry system (Ortho TSB) serving as a reference.Materials and MethodsMedical records of hospitalized neonates that underwent simultaneous Roche TBiL and Ortho TSB measurements were reviewed for eligibility selection and data collection. The correlations and differences between two sets of results were determined using Passing–Bablok regression analysis and a Bland–Altman plot, respectively. For eligible newborns, the risk of developing severe hyperbilirubinemia was assessed using the Bhutani nomogram. Weighted kappa analysis was used to evaluate the agreement between risk prediction by the two methods.ResultsWe obtained 618 paired Roche TBiL and Ortho TSB results from 309 neonates. Roche TBiL and Ortho TSB measurements showed a good correlation (r = 0.923; 95% CI: 0.905–0.938). Passing–Bablok regression analysis yielded the following equation: Roche TBiL = 0.794 × Ortho TSB + 1.255 mg/dL, with a slope of 0.794 (95% CI: 0.763–0.825) and intercept of 1.255 (95% CI: 1.042–1.417). The average difference between the two methods was 0.1 ± 1.448 mg/dL. A total of 207 neonates were eligible for evaluation of the agreement between the risk-grading methods. Although kappa analysis showed good agreement between the methods, with a weighted kappa of 0.681 (95% CI: 0.610–0.751) across all populations, the values for approximately half of the neonates at intermediate and high risk of hyperbilirubinemia (33/72) were underestimated by Roche TBiL.ConclusionOur results indicate that Roche TBiL and Ortho TSB measurements in the neonatal population are not consistent. As a point-of-care and trace blood assay, Roche blood gas bilirubin measurements can facilitate primary screening of neonatal hyperbilirubinemia, but it seems to lack accuracy regarding risk stratification, particularly for high-risk newborn individuals.
Clinical Significance of Serum Haptoglobin and Protein Disulfide-Isomerase A3 in the Screening, Diagnosis, and Staging of Colorectal Cancer
Authors: Niu Yajin , Xue Jun , Wu Xueliang , Qu Ming , Wang Likun , Liang Weizheng , Li Tian 
Published: July 2022

Objective: This study aims to explore the clinical significance of haptoglobin (HP) and protein disulfide-isomerase A3 (PDIA3) in human serum in the screening, diagnosis and staging of colorectal cancer (CRC), and to provide novel screening approaches featuring high specificity, sensitivity, and accuracy for early screening and diagnosis of clinical colorectal cancer.Methods: 88, 77, and 36 blood specimens were respectively harvested from colorectal cancer patients, colorectal polyp patients, and normal subjects (the health examination) who requested medical assistance from our hospital between Oct2019 and February 2022. The serum contents of HP and PDIA3 in each sample were determined through an enzyme linked immunosorbent assay (ELISA). This step was taken to analyze the differences among different specimen groups in terms of the serum contents of HP and PDIA3, to analyze the relationships between the expression levels of HP and PDIA3 and the pathological characteristics of colorectal cancer, and to explore the critical role of HP and PDIA3 in the screening, diagnosis, and staging of colorectal cancer.Results: Serum contents of HP and PDIA3 were higher in colorectal cancer patients, with statistical differences (p &lt; 0.05), than those in the colonic polyp patients and healthy subjects. Receiver operating characteristic (ROC) curve demonstrated that the cut-offs of HP and PDIA3 serum contents indicating colorectal cancer were 149 ug/ml and 66 ng/ml respectively. The individually and jointly tested AUCs of HP (0.802) and PDIA3 (0.727) were higher than those of serum CEA and CA199, the sensitivity and specificity of HP were 64.8 and 91.2%, the sensitivity and specificity of PDIA3 were 65.9 and 71.7%. Moreover, the contents of HP and PDIA3 increased alongside disease progression, with differences (p &lt; 0.05).Conclusion: Our research indicated that joint testing of HP and PDIA3 was of reference value for progressive stage and reliable biological indicators of colorectal cancer screening.
Impact of Depression on Patients With Hemophilia: A Retrospective Case-Control Research
Authors: Jiménez-Cebrián Ana María , Palomo-López Patricia , Becerro-de-Bengoa Vallejo Ricardo , Losa-Iglesias Marta Elena , Navarro-Flores Emmanuel , San-Antolín Marta , Calvo-Lobo César , López-López Daniel 
Published: July 2022

BackgroundHemophilia is an inherited recessive hemorrhagic disorder of the X-linked type, suffered by the male sex. Adults with hemophilia are coping with numerous diagnostics, associated comorbidities, pain, and difficult gait by arthropathy in ankles and feet. Physical pains contribute to depression in patients with hemophilia.PurposeThe study aimed to assess the impact of depression in adult patient with hemophilia and to compare it with healthy matched-paired controls. Methods: The sample consisted of 100 participants (median age 42.50 ± 30). Patients with hemophilia were recruited from Spanish Hemophiliac Associations (n = 50) and healthy subjects (n = 50) from a Clinic Podiatry Practices (University of Malaga, Spain).ResultsResults and categories of the Spanish-translated version of the Beck Depression Inventory (BDI) were gathered. A clear statistically significant difference (p &lt; 0.001) was presented in the variation of the BDI scores between both groups. Patients with hemophilia presented worse results with a BDI = 7.50 ± 11.25 points compared to healthy subjects with BDI = 2.50 ± 5 points. In the BDI categories, statistically significant differences (p = 0.004) were found in greater BDI categories in the Hemophilia group compared with healthy subjects. Moderate and severe depression categories were only shown in patients with hemophilia.ConclusionsGreater depression scores and range status were observed in patients with hemophilia compared to non-patients with hemophilia. Patients with hemophilia are at increased risk of depressiveness.
The Application of Platelet-Rich Plasma for Patients Following Total Joint Replacement: A Meta-Analysis of Randomized Controlled Trials and Systematic Review
Authors: Shu Hongxin , Huang Zhenjun , Bai Xinyan , Xia Zhiyu , Wang Nanye , Fu Xiaoling , Cheng Xigao , Zhou Bin 
Published: July 2022

BackgroundThe clinical efficacy of platelet-rich plasma (PRP) in the treatment of total joint replacement (TJR) remains inconclusive. In this paper, systematic review and meta-analysis was adopted to assess the efficacy of using PRP for the treatment of TJR.MethodsA comprehensive search of Medline, Embase, and Cochrane library databases for randomized controlled trial (RCT) articles recording data of PRP for TJR was conducted from inception to February 2022. Outcomes concerned were pain, range of motion (ROM), WOMAC score, length of hospital stay (LOS), hemoglobin (Hb) drop, total blood loss, wound healing rate, and wound infection. The methodological quality of the included RCTs was evaluated by using the Cochrane Risk of Bias Tool 2.0 (RoB 2.0). The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was utilized to assess the level of evidence for the outcomes. Subgroup analysis was conducted according to the type of TJR.ResultsTen RCTs were included in the meta-analysis. In the TKA subgroup, the available data demonstrated that there were significant differences in the outcomes of pain and Hb drop, while it was the opposite of ROM, WOMAC score, LOS, total blood loss, wound healing rate, and wound infection. In the THA subgroup, no significant differences could be seen between two groups in the outcomes of LOS and wound infection. However, the PRP group gained a higher wound healing rate in the THA subgroup.ConclusionThe application of PRP did not reduce blood loss but improved the wound healing rate. However, more prospective and multicenter studies are warranted to confirm these results.
Anatomy of Subpancreatic Transverse Colon Vessel and Its Clinical Significance: An Observational Study
Authors: Liao Jiankun , Qin Haiquan , Wei Li , Huang Zigao , Meng Linghou , Wang Wentao , Mo Xianwei 
Published: July 2022

PurposeTo observe and count the probability of presence and the anatomy of the vessel arising via the inferior margin of the pancreas and traveling within the transverse mesocolon, and analyze its clinical significance.MethodsPatients who underwent radical operation for transverse colon cancer or descending colon cancer from January 2020 to November 2021 and a nonspecific cadaver were included in this study. We observed and recorded intraoperatively for the probability of presence and the anatomy of the vessel arising via the inferior margin of the pancreas and traveling within the transverse mesocolon. And its property was determined by tissue slice.ResultsA total of 84 patients were included, of which, the vessel was observed in 72 (85.7%) patients, and its property was confirmed by tissue slice of one patient after surgery. The vessel was also observed in a nonspecific cadaver. Originating from transverse pancreatic artery, often one, occasionally two, rarely three vessels arose via the inferior margin of pancreas and supplied the left transverse colon. Artery and vein parallel ran, and it was difficult to separate them due to their small diameter, but the vessels may thicken under certain conditions for increasing blood supply.ConclusionThe vessel, which is not yet reported and named in the literature, can be called the subpancreatic transverse colon vessel, which has a high probability of presence in humans and may be of great significance to human physiological anatomy, surgery, and oncology, and deserves recognition and attention from surgeons.
Effect of Soaking in Chicken Eggshell Solution on Tooth Enamel Hardness
Authors: Yurisya Mila D. , Purbaningrum Diah A. , Hermawati Donna , Fortuna Gloria 
Published: July 2022

Abstract: Eggshell is one of the natural wastes which if not treated properly can cause environ-mental pollution. Broiler eggshells consist mostly of CaCO3 (calcium carbonate) that can be synthesized into CaO (calcium oxide) then be processed into Ca (calcium). Calcium has a function to fill the density of bones and teeth that affects their strength and hardness. This study aimed to determine the effect of soaking in broiler chicken eggshell solution on the hardness of tooth enamel. This was an experimental laboratory study with a posttest only control group design. Samples were 24 maxillary first premolar obtained from dental clinics, public health centers, and hospitals in Semarang, Indonesia. Samples were divided into four groups: control group and treatment groups 1, 2, and 3 (duration of soaking in eggshell solution for 2, 7, and 14 days. respectively). The one way ANOVA test resulted in a p-value of 0.000 which meant that there were significant differences in the four groups. The post hoc test showed a p-value of <0.05, which meant that there was a significant difference between the control group (artificial saliva) and the treatment groups of 2.7 and 14 days. In conclusion, chicken eggshell solution has an effect on increasing the hardness of tooth enamel.Keywords: tooth enamel; hardness of tooth enamel; chicken eggshell Abstrak: Cangkang telur merupakan salah satu limbah alam yang apabila tidak diolah dengan baik dapat menyebabkan pencemaran lingkungan. Komposisi cangkang telur ayam ras sebagian besar terdiri dari CaCO3 (kalsium karbonat) yang dapat disintesis menjadi CaO (kalsium oksida) dan selanjutnya diolah menjadi Ca (kalsium). Kalsium memiliki fungsi untuk mengisi kepadatan tulang dan gigi yang memengaruhi kekuatan serta kekerasannya. Penelitian ini bertujuan untuk mengetahui pengaruh perendaman larutan cangkang telur ayam ras terhadap kekerasan enamel gigi. Jenis penelitian ialah eksperimental laboratorik dengan posttest only control group design. Sampel penelitian ialah 24 gigi premolar satu rahang atas yang didapatkan dari klinik praktek dokter gigi, puskesmas dan rumah sakit di Kota Semarang. Sampel dibagi atas empat kelompok: kelompok kontrol dan kelompok perlakuan 1, 2, dan 3 (perendaman dalam larutan cangkang telur ayam ras selama 2, 7, dan 14 hari berturut). Hasil uji ANOVA one way memperoleh nilai p=0,000 yang berarti bahwa terdapat perbedaan bermakna pada keempat kelompok. Uji post hoc menunjukkan nilai p<0,05 yang berarti terdapat perbedaan bermakna antara kelompok kontrol (perendaman saliva artificial) dan kelompok perlakuan (perendaman larutan cangkang telur ayam ras 2, 7 dan 14 hari). Simpulan penelitian ini ialah perendaman dalam larutan cangkang telur ayam ras berpengaruh dalam peningkatan kekerasan enamel gigi.Kata kunci: enamel gigi; kekerasan enamel gigi; cangkang telur ayam ras
Pengelolaan Keuangan BUMDes: Upaya Mewujudkan Tujuan Pembangunan Berkelanjutan Desa
Authors: Suryo Wibowo Martinus Ivan , Sulistya Hapsari Aprina Nugrahesthy 
Published: July 2022

ABSTRACT
Village Owned Enterprises (BUMDes) are considered to have an important role in helping to realize the government's two national programs, namely the acceleration of the Village-Sustainable Development Goals (SDGs) and the Post-pandemic National Economic Recovery. Therefore, good and correct BUMDes Joint financial management is needed so that they can become the driving wheel of the village economy. This study aims to analyze and describe the financial management of BUMDes Bersama based on the principles of transparent, accountable, participatory village financial management, as well as orderly and budgetary discipline. This study uses a qualitative method with data obtained through non-structured interviews with several sources and supported by documentation. The implementation of the principles of financial management in the Joint BUMDes has been carried out, but there are still principles that are not optimal, especially the principles of transparency, accountability, and budget order and discipline. The lack of optimal implementation of this principle is motivated by the limited means of disseminating financial information that is easily accessible to the public and the limited capacity of human resources in preparing consolidated financial reports for the Joint BUMDes business unit.
ABSTRAK
Badan Usaha Milik Desa (BUMDes) Bersama dinilai memiliki peran penting dalam membantu mewujudkan dua program nasional pemerintah, yaitu percepatan Tujuan Pembangunan Berkelanjutan (SDGs) Desa dan Pemulihan Ekonomi Nasional pasca pandemi. Oleh karena itu, diperlukan pengelolaan keuangan BUMDes Bersama yang baik dan benar agar dapat menjadi roda penggerak perekonomian desa. Penelitian ini bertujuan untuk menganalisis dan mendeskripsikan pengelolaan keuangan BUMDes Bersama berdasarkan prinsip pengelolaan keuangan desa yang transparan, akuntabel, partisipatif, serta tertib dan disiplin anggaran. Penelitian ini menggunakan metode kualitatif dengan data diperoleh melalui wawancara non terstruktur kepada beberapa narasumber dan didukung dengan dokumentasi. Implementasi prinsip pengelolaan keuangan pada BUMDes Bersama sudah terlaksana, akan tetapi masih terdapat prinsip yang belum optimal terutama prinsip transparan, akuntabel, serta tertib dan disiplin anggaran. Belum optimalnya implementasi prinsip tersebut dilatarbelakangi oleh masih terbatasnya sarana penyebaran informasi keuangan yang mudah diakses oleh masyarakat dan terbatasnya kemampuan sumber daya manusia dalam Menyusun laporan keuangan konsolidasi atas unit usaha BUMDes Bersama.
Hubungan Substitusi Real Earning Management dan Accrual Earning Management terhadap Perilaku Pajak Agresif pada Perusahaan Kepemilikan Keluarga di Indonesia
Authors: Masri Indah 
Published: July 2022

ABSTRACT
This study looks at the effect of real earnings management (REM) and accrual earnings management (AEM) on tax aggressive behavior, and how the role of family companies on earnings management is applied to that relationship. The study was conducted on manufacturing companies during the period 2016 to 2019, with a total of 78 companies observing 312 company-years. With pool panel balance analysis, the research results show that in accordance with hypothesis 1 to hypothesis 5, that companies that do REM will tend to behave less aggressively than companies that do AEM, because there are no company limitations to do AEM, so companies that will do AEM tend to behave aggressive tax. In the test results in favor of family companies showing a tendency to aggressive behavior in Sari's research (2010). On the other hand, when family firms perform earnings management for tax purposes, they tend to switch to REM rather than AEM. These results contribute to earnings management behavior that is a substitute for accrual and real earnings management to aggressive tax behavior.
ABSTRAK
Penelitian ini melihat pengaruh real earning management serta accrual earning management pada perilaku pajak agresif, dan bagaimana peran perusahaan keluarga atas manajemen laba yang diterapkan entitas pada hubungan itu. Riset dilakukan pada perusahaan manufaktur selama periode 2016 hingga 2019, dengan total 78 perusahaan observasi 312 perusahaan-tahun. Dengan analisis pool panel balance, hasil penelitian menunjukkan sesuai dengan hipotesis 1 hingga hipotesis 5, bahwa perusahaan yang melakukan REM akan cenderung kurang berperilaku pajak agresif daripada perusahaan yang melakukan AEM, karena belum adanya keterbatasan perusahaan untuk melakukan AEM, sehingga perusahaan yang melakukan AEM cenderung akan berperilaku pajak agresif. Pada hasil pengujian di Perusahaan keluarga menampilkan kecenderungan perilaku pajak agresif mendukung penelitian Sari (2010). Sebaliknya ketika perusahaan keluarga melakukan manajemen laba untuk tujuan pajak cenderung akan beralih melakukan manajemen laba secara real daripada secara akrual. Hasil ini memberikan kontribusi atas perilaku manajemen laba yang bersifat substitusi atas real dan accrual earning management terhadap perilaku pajak agresif.
Effect of Concept-Mapping by using Frayer Model on Academic Achievement of Prospective Teachers
Authors: Akhtar Mubashara , Saeed Muhammad 
Published: July 2022

Frayer Model is the method of assessment used for concept making but there is still a debate in literature that how effectively Frayer Model helps in improving concept building. The main purpose of this research was to contribute in literature through investigating the effect of Frayer Model on academic achievement of prospective teachers. This study employed quasi-experimental design and sample were 87 prospective teachers. Before experiment, pretest of both groups was taken to ensure that they are at same level. After pretest, treatment was applied in different timeframes for the period of sixteen-weeks and then posttest was taken. Pretest and posttest were same that were developed by applying basic rules and guidelines of test development. The validity of the test was ensured by five experts in the field of assessment and curriculum whereas, psychometric analysis was used to measure the reliability and item characteristic of the test by piloting it on 200 prospective teachers. The data were also collected by using Frayer Model sheets to develop the concepts of prospective teachers on different areas of content taught i.e. foundations, models, designs, types etc. Dependent sample t-test was applied to explore the effect of Frayer Model on academic achievement of prospective teachers while independent sample t-test was applied to compare the scores of two groups. On the basis of research findings, it was concluded that Frayer Model has improved the concepts as well as academic achievement and understanding of prospective teachers. Further, it was recommended to use Frayer model in the classrooms to improve the students’ academic achievement and develop concepts.
Keywords: Academic Achievement, Assessment, Frayer Model, Prospective Teacher
Effectiveness of Information and Communication Technology (ICT) Integrated Teaching and Learning in Primary Schools
Authors: Roshan Muhammad , Ahmed Mushtaq , Bano Sher , Hussain Nasreen 
Published: July 2022

The aim of this study was to explore the effectiveness of Information and Communication Technology (ICT) integrated teaching and learning at primary level in Public Private Partnership (PPP) schools. The study also investigated how ICT is integrated for teaching and learning at primary level in PPP schools. The study was qualitative in design and employed phenomenological approach. Data for the study were collected through semi structured interviews, lesson observations and Focus Group Discussions (FGDs). The study participants were 15 teachers and 5 head teachers. The study indicated that the schools used Smart LED TVs and Tablet PCs with interactive e-learning application and story-based animated content of Science, English and Mathematics for teaching and learning in classroom. The findings of the study showed that ICT integration improved students’ academic achievements, increased their interest in learning and also increased students’ attendance and enrolment. The findings of the study also presented that ICT integration shifted teachers’ teaching practices from teacher centered to student centered, increased their interest in teaching and made teaching easier for them. The findings of the study may be helpful for different stakeholders working to improve the quality of education in the context of underprivileged areas especially PPP organizations, schools and teachers.
Keywords: Teaching and Learning, ICT Integration, Primary Schools, Technology Effectiveness, Public Private Partnership