bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reviewing prognostic factors associated with recurrence in clinically early-stage low-risk endometrial cancer
Authors: Batista Thales Paulo , Santana Rafael Palmeira , Augusto Camilla Maria Guimarães , Morais Nivaldo Sobral , Ventura Maria Lídia Amaral Barbosa , Bezerra Artur Lício Rocha 
Published: April 2022

ABSTRACT
Objective: We sought to re-explore the association between well-known prognostic factors and recurrence in presumed early-stage low-risk endometrial cancer (EC).
Methods: A retrospective cohort study was carried out on patients who underwent surgical treatment by the same surgeon for presumed early-stage low-risk EC between September 2003 to August 2017. The prognostic value of well-known clinicopathological factors for diseasefree survival (DFS) was reviewed by univariate log-rank test.
Results: One hundred and five patients fit the criteria for this analysis. These patients underwent total hysterectomy plus bilateral salpingo-oophorectomy with no lymph nodes dissection (10.5%) or with a sampling dissection alone (89.5%). Adjuvant therapies were applied in 52 (40.1%) of them as pelvic radiotherapy (29.5%) or chemoradiation (11.4%). Our cumulative 3y-DFS and OS were 88.1% and 97.7%, respectively. The univariate survival analysis confirmed histological grade 3 (3y-DFS of 89.9% vs. 33.3%, p=0.004), MMI ≥50% (3y-DFS of 95.2% vs. 71.3%, p=0.003), lymph node metastasis (3y-DFS of 88.3% vs. 60%; p=0.028) and more advanced pathological stages (3y-DFS of 91.2% vs. 56.3; p<0.001) as significantly associated to recurrences.
Conclusion: We confirmed the association of classical prognostic factors such as high histological grade, deeper MMI, lymph node metastasis and more advanced pathological stages with disease recurrence in this cohort of patients from Northeast Brazil. Further efforts are needed to avoid overtreatment in patients with low risk of relapses.
Pediatric related risk factors in acute and delayed chemotherapyinduced nausea and vomiting: multivariate analysis
Authors: Albuquerque Ariádne Sousa , Okumura Lucas Miyake , Betin-de-Moraes Nelci Rodrigues , Ricieri Marinei Campos , Barros Tais Tereziano , Fachi Mariana Millan 
Published: April 2022

ABSTRACT
Objectives: This study aimed to characterize the clinical profile and the factors that predispose chemotherapy-induced nausea and vomiting (CINV) in the acute and delayed phases.
Methods: A retrospective cohort study was conducted in a Brazilian hospital with pediatric patients under 18 years old receiving moderately or highly emetogenic chemotherapy. Thus, a descriptive analysis was performed to characterize this population, followed by univariate and multivariate analysis to evaluate the risk factors for CINV. In both phases, considering significant the variables with p-values <0.05.
Results: The median age was 6 and 71% of the patients included used highly emetogenic protocols. Furthermore, 41% and 76% did not have vomit in the acute and delayed phase, respectively. Through logistic regression, it is noted that patients with bone tumors and sarcomas have higher CINV in the acute phase (OR 10.0, 95%IC 1.1-88.9, p=0.039), while patients who do not have complete control in the acute phase are more likely to have CINV in the delayed phase (OR 11.8, 95%IC 1.1-130.5, p=0.044).
Conclusion: These results suggest that bone tumors and sarcomas are associated with an increase in CINV in the acute phase. In addition, control in the acute phase is associated with a complete response in the delayed phase.
Safe prescription of systemic antineoplastic treatment in oncology: integrative literature review
Authors: Alves Fabiola Vasconcelos , Silveira Renata Cristina de Campos Pereira , Cruz Flavia Oliveira de Almeida Marques da , Ferreira Elaine Barros , Reis Paula Elaine Diniz dos 
Published: April 2022

ABSTRACTThe objective of this study was to identify the available evidence on the parameters that should be considered to improve the quality and safety of the prescription of systemic antineoplastic treatment. This is an integrative review carried out in the EMBASE, LILACS, and PubMed databases, from 2015 to 2019. The methodological quality of the included studies was assessed by the tools of the Joanna Briggs Institute. Eight studies were included, of which 5 addressed adverse events related to systemic antineoplastic treatment, including 4,970 patients treated with immunotherapy, target therapy, and chemotherapy. One study assessed the safety of prescribing antineoplastic agents and 2 studies addressed pharmacovigilance and risk management by assessing treatment- related adverse effects. Chemotherapy, target therapy, and immunotherapy have different toxicity profiles. The evidence suggests that assessment of treatment toxicity as well as risk management should be considered to improve the quality and safety of prescribing systemic antineoplastic treatment.
Physical activity recommendations for cancer prevention and control: a Brazilian consortium
Authors: Deminice Rafael , Rezende Leandro F M , Rosa Daniela Dornelles , Cangussu Renata , Garcia Leandro Martin Totaro , Riera Rachel , Carvalho Fabio Fotunato Brasil , Silva Ronaldo Côrrea Ferreira , Brum Patrícia Chakur 
Published: April 2022

ABSTRACT
Objective: This article describes the development process and summarizes the results of the Brazilian physical activity recommendations for cancer prevention and control, which was prepared to support health-care professionals.
Material and Methods: These recommendations were elaborated considering: (i) the effect of physical activity on cancer prevention in the general healthy population; and (ii) on all-cause and cancer-specific mortality in cancer survivors. The process of preparing the recommendations was systematized, transparent and reproducible, following the recommendations of the appraisal of guidelines for research and evaluation (AGREE-II). We appraised the certainty of evidence for breast, prostate, colorectal and lung cancers, which are among the most frequent in Brazil, using the grading of recommendations, assessment, development and evaluations (GRADE) approach.
Results: Regarding the risk of cancer, we found high certainty of evidence supporting the association between moderate-to-vigorous physical activity and lower risk of breast and colon cancer, moderate certainty of evidence for lung cancer and low certainty of evidence for prostate and rectal cancer. We found moderate certainty of evidence supporting the association between moderate-to-vigorous physical activity and reduction of all-cause and cancer-specific mortality from breast, colon and rectal cancer, and cancer-specific mortality from prostate cancer, when physical activity was performed after the disease diagnosis. We found low certainty of evidence for the association between physical activity and lung cancer mortality. Based on our findings, physical activity recommendations were proposed, including a step-by-step guide to support health-care professionals when recommending physical activity for all adults (including elderly people), with or without a diagnosis of cancer.
Conclusion: Our recommentations may be useful to support health-care professionals counselling for physical activity, which contribute to reductions in physical inactivity in the general population and in the growing population of cancer survivors.
Problems Faced by the Dairy Farmers in Palakkad District of Kerala, India
Authors: Maria Poulose T. , Veerakumaran G. 
Published: April 2022

Aims: The dairy industry in India is instrumental in providing cheap and nutritional food to the vast population of India and also generates huge employment opportunities for people in rural areas. Milk is the largest product from the agriculture and allied sector in India in terms of value at Rs.6.5 lakh crore. It contributes around 26 per cent of total agriculture’s Gross Domestic Product (GDP). The Kerala currently represents the twelfth largest dairy market in India. The livestock population in Kerala was 38.36 lakh in the year of 2019 [1]. Dairying is a major subsidiary occupation for the farmers of Kerala. But present-day dairying is faced with a number of challenges. The study was conducted to explore various constraints associated with dairy farming as perceived by the farmers.
Objective: To identify the problems faced by dairy farmers in Palakkad district of Kerala.
Methodology: The primary data for this study were collected using a structured interview schedule from 200 active dairy farmer respondents from four selected dairy co-operatives in the Palakkad district.
Results: The temperature variation was the major factor behind the milk production problems. Because Kerala's highest temperature was always recorded in the Palakkad district. But none of the dairy farmers were facing difficulties with milk procurement. All of them were satisfied with the procurement facilities and arrangements. Low accessibility to veterinary services and a lack of sufficient labour were the main problems faced by the selected dairy farmers. Out of 200 dairy farmers, none of them were affected by the floods of 2018 and 2019. The quantity of milk procured by the dairy co-operative society, transportation, profit from the sale of milk, and labour services were mainly affected due to the COVID 19 pandemic. The lack of availability of schemes and support is one of the main problems faced by the respondents. Lack of knowledge about banking services and functions related to subsidies was also one of the problems that existed among them.
Conclusion: From the study, it became evident that dairy farming activities in Kerala, though growing are crippled by a range of problems. The appointment of a trained Artificial insemination, Veterinary First Aid worker, creation of labour groups and continuous monitoring of the progress of schemes and services can solve the problems faced by dairy farmers up to a limit. Finally, this will result in the widening of our country's dairy sector.
MENJAGA KESEHATAN MENTAL DI KENORMALAN BARU PADA MASA PANDEMI COVID-19
Authors: Andrini Susi , Surasmi Rahayu 
Published: April 2022

Sekolah Tinggi Ilmu Komunikasi (Stikom) Inter Studi, yang tergabung antara dosen dan mahasiswa khususnya Mahasiswa Konsentrasi Public Relations angkatan 2018, pada mata kuliah Corporate Social Responsibility (CSR) and Ethic, mengadakan kegiatan Pengabdian Kepada Masyarakat. Kegiatan online ini bertemakan “Re-Set Our Mental Health In New Normal“, dengan Judul, “Menjaga Kesehatan Mental di Kenormalan Baru Pada Masa Pandemi covid-19.” Secara umum pandemik Covid-19, telah menimbulkan tingkat kecemasan yang tinggi di antara banyak penduduk dunia dan sebagian masyarakat Indonesia, yang juga tak luput dari rasa kecemasan ini. Karena rasa cemas ataupun takut (Phobia) yang berlebihan ini dapat mengganggu aktifitas dan kesehatan mental. Saat ini kita hidup di era “New Normal” atau hidup di masa kenormalan baru, akan tetapi pengaruh pandemi ini masih mempengaruhi kondisi mental sebagian masyarakat. Dikarenakan masa pandemi ini menyebabkan adanya “social distancing” keterbatasan jarak yang tidak memungkinkan adanya melakukan kegiatan secara langsung atau secara offline dengan jumlah banyak orang, maka kegiatan Pengabdian Kepada Masyarakat ini dilakukan secara online. Adapun tujuan dari kegiatan ini adalah untuk memberikan pengetahuan dan pemahaman kepada masyarakat agar dapat menjaga kembali kesehatan mental di masa pandemi Covid-19 baik secara teoritis dan praktiknya dengan melakukan olah pernafasan dalam yoga yang dapat memberikan rasa tenang dan nyaman untuk mengurangi stress. Hasil dari kegiatan ini sangat positif dan pikiran menjadi fresh dan tenang setelah para peserta melakukan yoga. Kegiatan ini dilaksanakan pada hari Kamis, 16 Juli 2020 dengan jumlah peserta sebanyak 73 peserta yang terdiri dari dosen, mahasiswa dan umum.
Ionogel‐Based Membranes for Safe Lithium/Sodium Batteries
Authors: Wang Sen , Jiang Yingjun , Hu Xianluo 
Published: April 2022

AbstractAlkali (lithium, sodium)‐based second batteries are considered one of the brightest candidates for energy‐storage applications in order to utilize the random and intermittent renewable energy to achieve carbon neutrality. Conventional lithium/sodium batteries containing liquid organic electrolytes are vulnerable to electrolytes leakage and even combustion, which hinders their large‐scale and reliable application. All‐solid‐state electrolytes which are considered to have better safety have been developed in recent years. However, most of them suffer from low ionic conductivity and large interfacial resistance with the electrode. Ionogel‐electrolyte membranes composed of ionic liquids and solid matrices, have attracted much attention because of their nonvolatility, nonflammability, and superior chemical and electrochemical properties. This review focuses on the most recent advances of ionogel electrolytes that sprang up with the emerging demand and progress of safe lithium/sodium batteries. The ionogel‐electrolyte membranes are discussed based on the framework components and preparation methods. Their structure and properties, including ionic conductivity, mechanical strength, electrochemical stabilities, and so on, are demonstrated in combination with their applications. The current challenges and insights on the future development of ionogel electrolytes for advanced safe lithium/sodium batteries are also proposed.
Combining diffusive gradients in thin‐films (DGT) and 31P NMR spectroscopy to determine phosphorus species in soil
Authors: Vogel Christian , Doolette Ashlea , Huang Jianyin 
Published: April 2022

AbstractThe diffusive gradients in thin‐films (DGT) technique shows in many publications a superior correlation to the amount of plant‐available phosphorus (P) in soil. However, this technique cannot give information on the plant‐available P species in soil. Therefore, we combined DGT with solution 31P nuclear magnetic resonance (NMR) spectroscopy. This was achieved by using a modified DGT device in which the diffusive layer had a larger pore size, the binding layer incorporated an adsorption material with a higher capacity, and the device had a larger exposure area. The spectroscopic investigation was undertaken after elution of the deployed DGT binding layer in a NaOH solution. Adsorption tests using solutions of known organic P compounds showed that a sufficient amount of these compounds could be adsorbed on the binding layer in order for them to be analyzed by solution 31P NMR spectroscopy. Furthermore, various intermediates of the hydrolysis of trimetaphosphate in soil could be also analyzed over time.Core Ideas

We show a promising combination of DGT technique and solution 31P NMR spectroscopy.
This technique combination can identify organic phosphorus species in solutions.
Modified DGT device can analyze the hydrolysis of trimetaphosphate in soil.
Mixed neuroendocrine‐non‐neuroendocrine neoplasms of the ampulla of Vater: A case report and literature review
Authors: Chen Chien‐Hung , Kuo Hsing‐Tao , Sheu Ming‐Jen , Sun Chi‐Shu , Lin Yu‐Min , Win Khin Than , Feng I‐Che 
Published: March 2022

AbstractMixed neuroendocrine‐non‐neuroendocrine neoplasms (MiNENs) of the ampulla of Vater are extremely rare. We present a case of a MiNEN of the ampulla of Vater and review the literature related to management and treatment recommendations. A 72‐year‐old woman presented with Charcot's triad for a week. Computed tomography revealed a periampullary tumor. Endoscopic retrograde cholangiopancreatography with internal drainage and sphincterotomy with biopsy revealed mixed adenocarcinoma‐neuroendocrine carcinoma. Ampullary MiNEN with an American Joint Committee on Cancer (8th edition) TNM classification of Stage IIIA T3bN1M0 was diagnosed, and the Whipple procedure was performed. Both components of the tumor were of high grade, each component accounting for approximately 50% of the tumor. FOLFOX (oxaliplatin + de Gramont) was prescribed as adjuvant chemotherapy. No recurrence was noted at the 3‐month follow‐up. Diagnosis of MiNENs through biopsies is challenging, and core biopsies should be suggested when a surgical sample is unavailable. Although heterogeneous, MiNENs are usually highly aggressive neoplasms, contributing to the dissemination of metastases and poor prognosis. In conclusion, radical resection is the optimal treatment choice for almost all potentially curable cases. In addition, treatment strategies for patients with a new diagnosis of MiNENs of the ampulla of Vater should be formulated after discussions in multidisciplinary meetings and should be based on the most aggressive and predominant component in the diagnostic sample.
A unique pancreatic phenotype in a child with a WDR19‐related ciliopathy: A case report and literature review of pancreatic involvement in ciliopathies
Authors: Keyser Michelle Nguyen , Huang Maria , Newton Kimberly , Benador Nadine , Beauchamp‐Walters Julia , Bird Lynne M. 
Published: April 2022

AbstractCiliopathies are a group of genetic disorders caused by ciliary dysfunction. Thirty‐five distinct multi‐organ phenotypes have been recognized, with 187 genes associated. We performed a literature review of pancreatic involvement in ciliopathies and found that pancreatic disease is an uncommon phenotype described in only a handful of these genetic disorders. We present a case report of a pediatric patient with WDR19‐related ciliopathy whose degree of pancreatic disease exceeds what has previously been reported in the literature for WDR19‐related ciliopathies. WDR19 is one member of the nephronophthisis (NPHP)‐related ciliopathy gene family and encodes an intra‐flagellar transport protein (IFT144). Our patient presented with restrictive and obstructive lung disease, short rib thoracic dysplasia, end‐stage renal disease (ESRD), developmental delay, hepatic fibrosis, and severe recurrent pancreatitis. Whole‐exome sequencing (GeneDx) showed two likely pathogenic WDR19 variants in trans (maternally inherited: c.742G > A, p.G248S; paternally inherited: c.617 T > C, p.L206P). Among WDR19‐related ciliopathies, pancreatic involvement is rarely reported and there have been no cases of severe, recurrent pancreatitis. Through this case report and literature review we hope to emphasize that pancreatic involvement is a rare yet important clinical phenotype to recognize in ciliopathies, especially in WDR19‐related ciliopathies.
Biomarker clustering in autosomal dominant Alzheimer's disease
Authors: Luckett Patrick H. , Chen Charlie , Gordon Brian A. , Wisch Julie , Berman Sarah B. , Chhatwal Jasmeer P. , Cruchaga Carlos , Fagan Anne M. , Farlow Martin R. , Fox Nick C. , Jucker Mathias , Levin Johannes , Masters Colin L. , Mori Hiroshi , Noble James M. , Salloway Stephen , Schofield Peter R. , Brickman Adam M. , Brooks William S. , Cash David M. , Fulham Michael J. , Ghetti Bernardino , Jack Clifford R. , Vöglein Jonathan , Klunk William E. , Koeppe Robert , Su Yi , Weiner Michael , Wang Qing , Marcus Daniel , Koudelis Deborah , Joseph‐Mathurin Nelly , Cash Lisa , Hornbeck Russ , Xiong Chengjie , Perrin Richard J. , Karch Celeste M. , Hassenstab Jason , McDade Eric , Morris John C. , Benzinger Tammie L.S. , Bateman Randall J. , Ances Beau M. ,   for the Dominantly Inherited Alzheimer Network (DIAN)
Published: April 2022

AbstractINTRODUCTIONAs the number of biomarkers used to study Alzheimer's disease (AD) continues to increase, it is important to understand the utility of any given biomarker, as well as what additional information a biomarker provides when compared to others.METHODSWe used hierarchical clustering to group 19 cross‐sectional biomarkers in autosomal dominant AD. Feature selection identified biomarkers that were the strongest predictors of mutation status and estimated years from symptom onset (EYO). Biomarkers identified included clinical assessments, neuroimaging, cerebrospinal fluid amyloid, and tau, and emerging biomarkers of neuronal integrity and inflammation.RESULTSThree primary clusters were identified: neurodegeneration, amyloid/tau, and emerging biomarkers. Feature selection identified amyloid and tau measures as the primary predictors of mutation status and EYO. Emerging biomarkers of neuronal integrity and inflammation were relatively weak predictors.DISCUSSIONThese results provide novel insight into our understanding of the relationships among biomarkers and the staging of biomarkers based on disease progression.
Information‐seeking when information doesn't matter
Authors: Hilchey Matthew D. , Rondina Renante , Soman Dilip 
Published: April 2022

AbstractPrior research shows that investors check their portfolios less frequently when they believe negative returns on investments are likely. This so‐called ostrich effect is accounted for by belief‐based utility theories that suggest that information demand is determined by the potential of information to evoke or maintain pleasant beliefs. An alternative is that information matters as there are more courses of action that investors would take with positive than negative portfolio returns. Across three experiments, we adapt a non‐instrumental sampling paradigm to verify whether people are more likely to seek out information when expecting small gains as compared to losses when the instrumental utility of outcome information is 0. We also explore whether the effect can be attenuated by making outcome information easier to find. Our findings suggest that people are more likely to initiate and persist in search for prospective financial gains than losses, and for unknown than known financial outcomes, even though confirming any given outcome is effectively useless. The magnitude of the ostrich effect increased with increased certainty of a financial gain and loss. Making outcome information easier to find increased the likelihood that an outcome would be discovered but did not strongly modify intent to seek it out or moderate ostrich effects. We discuss how the findings are consistent with non‐instrumental utility frameworks for information demand, inconsistent with literature showing greater attention to financial loss than gain outcome information, and propose testable hypotheses for resolving the discrepancy.
Bauphysikalische Voruntersuchungen in der Planungsphase des CUBE
Authors: Stelzmann Mario , Kupke Marén , Kahnt Alexander 
Published: April 2022

AbstractBei der Planung und Entwicklung des CUBE wurden die bauphysikalischen Aspekte des Gebäudes betrachtet. Im Vorfeld erfolgten dafür verschiedene rechnerische und experimentelle Untersuchungen wie Simulationen zum Energiebedarf nach DIN V 18599. Der im Planungsprozess angestrebte Passivhausstandard konnte nicht realisiert werden. Messungen zur Luftschalldämmung des TWIST‐Bauteilaufbaus in einem Schallprüfstand zeigten keine schallschutztechnische Entkopplung der 4 cm dicken Wetterschale. Ferner ging aus raumakustischen Simulationsberechnungen hervor, dass die harten Oberflächen der Sichtbetonwände und der Sichtbetondecken sowie des Fußbodens und der Glasfassade zu einer ungünstigen Akustik mit langen Nachhallzeiten führen würde. Für die Entwicklung eines Feuchteschutzkonzepts wurden verschiedene theoretische Betrachtungen sowie Untersuchungen durchgeführt.
Recent patents in allergy and immunology: A quantitative real‐time polymerase chain reaction method for diagnosing asthma and asthma exacerbation
Authors: Lee Pureun‐Haneul , Choi SeonMuk , An MinHyeok , Jang An‐Soo 
Published: April 2022

AbstractBackgroundAsthma is diagnosed based on a history of the characteristic symptoms and evidence of expiratory airflow limitation. However, asthma diagnosis using the existing tests is associated with a risk of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 spread. In this study, we developed a quantitative real‐time polymerase chain reaction (qRT‐PCR)‐based asthma diagnosis tool.MethodsWe detected nectin‐4 in the plasma of patients with asthma using qRT‐PCR, explored the relationship of clinical variables.Resultsquantitative real‐time polymerase chain reaction revealed that plasma nectin‐4 mRNA levels were higher in asthmatics than controls. These results correlated with lung function.ConclusionsThose results suggest that qRT‐PCR for nectin‐4 may aid asthma diagnosis and monitoring.