bluuebunny/crossref_metadata_2025_split huggingface dataset:
Team Self-Maintenance during Long-Duration Space Exploration: A Conceptual Framework
Authors: Wildman Jessica L. , Fedele Dominic , Wilder Anderson , Curtis Michael T. , DiazGranados Deborah 
Published: March 2022

Objective We developed a conceptual framework of Team Self-Maintenance (TSM) within long-duration space exploration (LDSE), which we define as the process of monitoring, adjusting, and maintaining the psychological well-being of a team in the absence of external support. Background Specific to LDSE and isolated, confined, and extreme (ICE) environments, periods of routine can have a debilitating effect on the crew’s well-being and performance, and TSM is a critical process for avoiding these detrimental effects. Method Based on themes drawn from nine subject matter expert interviews combined with an extensive literature review on related concepts, we developed an integrative conceptual framework of the key inputs, processes, and outputs involved in TSM within LDSE contexts. Results Our TSM framework suggests team well-being as a key outcome that must be maintained during LDSE and information sharing, self-regulation, resource recovery, and emotional support as the key processes that enable team well-being. We also identify several contextual inputs that can serve as intervention points for enabling effective TSM. Conclusion Our framework suggests that future research and practice aimed at effective LDSE should emphasize team well-being, rather than just performance, and that there are many open questions in terms of how teams will manage their own socio-emotional needs (e.g., conflict, recovery activities, and boredom) without external systems and support. Application This conceptual framework describes the primary inputs, processes, and outcomes involved in the team self-maintenance process. This framework reflects context-specific theorizing most likely to be applicable only to LDSE contexts.
Investigating the opportunity for cooling the London underground through waste heat recovery
Authors: Lagoeiro Henrique , Revesz Akos , Davies Gareth , Gysin Ken , Curry Daniel , Faulks Gareth , Murphy Declan , Vivian Josh , Maidment Graeme 
Published: March 2022

Recovering waste heat from urban infrastructures is becoming increasingly important as the UK strives to decarbonise heat, which remains one of the main challenges in the transition towards net zero. The Bunhill Waste Heat Recovery (WHR) System represents a first of its kind scheme that will recover waste energy from a ventilation shaft of the London Underground (LU) transport network. The system is based upon the installation of a heat recovery heat exchanger that consists of cooling coils and a reversible fan. The coils are connected to a heat pump that supplies low-carbon thermal energy to the Bunhill Heat Network in Central London. One particularly important aspect of the Bunhill WHR system is its ability to operate in a way that not only provides heating to the local heat network, but can also simultaneously supply cooled air to the LU tunnels depending on the operation of the reversible fan. The current paper estimates the potential cooling benefit that could be achieved with the WHR system based upon the development of a mathematical model. The model is able to predict the condition of the coil surface according to air inlet parameters, and this is used to calculate the latent and sensible cooling loads, which are applied to simulate how the system affects the local tunnel environment, with peak temperature reductions of up to 7.2 K being estimated for adjacent stations in 2030. The results from the investigation are presented together with recommendations for further development and future deployment of heat recovery from metro systems, as this technology could be applied across London and elsewhere to deliver significant carbon and cost savings while improving the thermal environment of railway tunnels. Practical Application This work investigates the cooling potential behind a practical project that involves recovering waste heat from the LU network. As electrification leads to an increased deployment of heat pump and district heating systems, waste heat could become a valuable resource for maximising energy efficiency, even more so when additional cooling benefits can be achieved. This paper aims to explore the impacts of cooling on railway tunnels, emphasising how secondary benefits, which are many times overlooked, could be critical to making waste heat recovery economically feasible, maximising its potential as a key technology for decarbonising heat.
Cross-Cultural adaptation and validation of the Exercise-Induced Leg Pain questionnaire for Spanish speaking patients
Authors: Castillo-Domínguez Alejandro , Alvero-Cruz José Ramón , Páez-Moguer Joaquín , Nauck Tanja , Lohrer Heinz , Scheer Volker , García-Romero Jerónimo 
Published: March 2022

Objectives To cross-culturally adapt and validate a Spanish version of the Exercise-Induced Leg Pain questionnaire. Design Clinical measurement study. Participants The validity and reliability of the adapted version were assessed in four groups of 40 patients with exercise-induced leg pain, 40 physically active healthy individuals (control group), 40 athletes with other leg conditions and 40 athletes, military personnel and candidates with no history of injury (risk group). Main measure Exercise-Induced Leg Pain questionnaire. Reference measures Spanish version of the Short-Form 36 and Schepsis postsurgical classification scale. Results In patients with exercise-induced leg pain, the mean age was 24.9 (± 6.7) years and the mean score of the questionnaire was 62.8 (± 10.9). The standard error of measurement and minimum detectable change threshold were 1.67 and 4.63 points, respectively. Excellent internal consistency (Cronbach’s α = 0.942) and test-retest reliability (intraclass correlation coefficient = 0.995) were found. The exploratory and confirmatory factor analyses indicated that a one-factor solution explained 66.84% of the variance. For construct validity, 87.5% of the previously stated hypotheses were fulfilled between the total score of the questionnaire and Short-Form 36 dimensions. Concurrent validity, assessed by the Schepsis scale, was almost perfect (r = 0.92, p < 0.001). The predictive validity of the questionnaire was demonstrated using the receiving operating curve (area of 0.992; 95% CI: 0.983–1, p < 0.001). Conclusion The Spanish version of the Exercise-Induced Leg Pain questionnaire resulted in a reliable and valid instrument to assess patients with exercise-induced leg pain.
It’s like standing in front of a prison fence – Dying during the SARS-CoV2 pandemic: A qualitative study of bereaved relatives’ experiences
Authors: Pauli Berenike , Strupp Julia , Schloesser Karlotta , Voltz Raymond , Jung Norma , Leisse Charlotte , Bausewein Claudia , Pralong Anne , Simon Steffen T ,   for the PallPan consortium
Published: March 2022

Background: Since the onset of the SARS CoV2 pandemic, protective and isolation measures had a strong impact on the care and support provided to seriously ill and dying people at the end-of-life. Aim: Exploring bereaved relatives’ experiences of end-of-life care during the SARS-CoV2 pandemic. Design: Qualitative interview study with bereaved relatives. Participants: Thirty-two relatives of patients who died during the pandemic, regardless of infection with SARS-CoV2. Results: Three core categories were identified: needs, burden and best practice. Relatives wished for a contact person responsible for providing information on the medical and mental condition of their family members. The lack of information, of support by others and physical closeness due to the visiting restrictions, as well as not being able to say goodbye, were felt as burdens and led to emotional distress. However, case-by-case decisions were made and creative ways of staying in touch were experienced positively. Conclusions: Our results indicate that the strong need for closeness when a family member was dying could not be met due to the pandemic. This led to suffering that can be prevented. Visits need to be facilitated by making considered decisions on a case-by-case basis. For easy communication with relatives, approaches should be made by healthcare professionals and support for virtual communication should be offered. Furthermore, the results of the study can help to implement or develop ideas to enable dignified farewells even during pandemics.
Analysis of synthetic magnetic resonance images by multi-channel segmentation increases accuracy of volumetry in the putamen and decreases mis-segmentation in the dural sinuses
Authors: Goto Masami , Fukunaga Issei , Hagiwara Akifumi , Fujita Shohei , Hori Masaaki , Kamagata Koji , Aoki Shigeki , Abe Osamu , Sakamoto Hajime , Sakano Yasuaki , Kyogoku Shinsuke , Daida Hiroyuki 
Published: March 2022

Background Voxel-based morphometry (VBM) using magnetic resonance imaging (MR) has been used to estimate cortical atrophy associated with various diseases. However, there are mis-segmentations of segmented gray matter image in VBM. Purpose To study a twofold evaluation of single- and multi-channel segmentation using synthetic MR images: (1) mis-segmentation of segmented gray matter images in transverse and cavernous sinuses; and (2) accuracy and repeatability of segmented gray matter images. Material and Methods A total of 13 healthy individuals were scanned with 3D quantification using an interleaved Look–Locker acquisition sequence with a T2 preparation pulse (3D-QALAS) sequence on a 1.5-T scanner. Three of the 13 healthy participants were scanned five consecutive times for evaluation of repeatability. We used SyMRI software to create images with three contrasts: T1-weighted (T1W), T2-weighted (T2W), and proton density-weighted (PDW) images. Manual regions of interest (ROI) on T1W imaging were individually set as the gold standard in the transverse sinus, cavernous sinus, and putamen. Single-channel (T1W) and multi-channel (T1W + T2W, T1W + PDW, and T1W + T2W + PDW imaging) segmentations were performed with statistical parametric mapping 12 software. Results We found that mis-segmentations in both the transverse and cavernous sinuses were large in single-channel segmentation compared with multi-channel segmentations. Furthermore, the accuracy of segmented gray matter images in the putamen was high in both multi-channel T1W + PDW and T1W + T2W + PDW segmentations compared with other segmentations. Finally, the highest repeatability of left putamen volumetry was found with multi-channel segmentation T1WI + PDWI. Conclusion Multi-channel segmentation with T1WI + PDWI provides good results for VBM compared with single-channel and other multi-channel segmentations.
Nanofibers from hydroxypropyl β-cyclodextrin/pantothenic acid supramolecular complexes: Physicochemical characterization and potential biomedical applications
Authors: Mohandoss Sonaimuthu , Palanisamy Subramanian , You SangGuan , Vinosha Manoharan , Rajasekar Periyannan , Velu Kuppu Sakthi , Lee Yong Rok , Prabhu Narayanasamy Marimuthu 
Published: March 2022

The electrospinning of nanofibers (NFs) from 2-hydroxypropyl β-cyclodextrin supramolecular inclusion complexes (150% HPβ-CD, w/v) with vitamin B5 (pantothenic acid [PA]) was achieved without using any carrier polymeric matrix. The presence of PA and the formation of the HPβ-CD/PA inclusion complex within the NFs structure were confirmed by SEM, FTIR, XRD, and TGA analysis. SEM images depicted the bead-free uniform NFs and confirmed the incorporation of HPβ-CD/PA NFs did not alter the fiber morphology having an average fiber diameter of 512 ± 24 nm, 328 ± 18 nm, and 150 ± 19 nm, respectively. Fourier transform infrared (FTIR) spectrum indicated inclusion complex from the shifting of the peaks of each component in HPβ-CD/PA NFs, whereas XRD pattern revealed that HPβ-CD/PA NFs was achieved due to the formation of a new amorphous structure. TGA studies showed that the stability of PA after HPβ-CD encapsulation was improved. Molecular docking was used to simulate the positions and interactions of the binding sites of the HPβ-CD/PA inclusion complex. The phase solubility test showed enhanced solubility of PA due to the inclusion complexation; in addition, the stoichiometry of HPβ-CD/PA was determined to be 1:1. The release of PA from HPβ-CD/PA NFs prevented the colonization of Escherichia coli (5.0 ± 0.3%) and Staphylococcus aureus (2.0 ± 0.5%) bacteria to a great extent, as observed in the antibacterial activity results. The cell viability of HCT-116 cells treated with 100 μg/mL of HPβ-CD/PA NFs was registered at 97.5 ± 2.1%. It was observed that HPβ-CD/PA NFs had higher anticancer activity compared to pure PA and HPβ-CD due to the solubility increase. In brief, our results suggested that polymer-free HPβ-CD/PA inclusion complex NFs could have potential applications in food, pharmaceuticals, and healthcare thanks to its efficient antibacterial and anticancer activities.
Be Careful what You Count: Updating Legislative Turnover in the 50 States
Authors: Butcher Jordan 
Published: March 2022

Legislative turnover is indicative of political careerism, district competitiveness, and the strength of the incumbency advantage. Although there are many examinations of legislative turnover in U.S. state legislatures, there has not been an update in nearly 2 decades. One limitation of the existing turnover measures is the inability to distinguish between naturally occurring turnover and the artificial turnover caused by term limits. In this research note, I present an update to legislative turnover from 2002 to 2018 and discuss the importance of using updated data, as well as avenues for future research.
A multicenter phase II study on the efficacy and safety of hetrombopag in patients with severe aplastic anemia refractory to immunosuppressive therapy
Authors: Peng Guangxin , He Guangsheng , Chang Hong , Gao Sujun , Liu Xinjian , Chen Tong , Li Pei , Han Bing , Miao Miao , Ge Zheng , Ge Xiaoyan , Li Fei , Li Yingmei , Wang Shunqing , Wang Yi , Shen Yaqi , Zhang Tao , Zou Jianjun , Zhang Fengkui 
Published: March 2022

Background: In this single-arm phase II study (NCT03557099), we evaluated the efficacy and safety of hetrombopag, a small molecule thrombopoietin (TPO) receptor agonist, in patients with severe aplastic anemia (SAA) who were refractory to standard first-line immunosuppressive therapy (IST). Methods: SAA patients who were refractory to standard first-line IST were given hetrombopag orally at an initial dose of 7.5 mg once daily to a maximum of 15 mg once daily, for a total of 52 weeks. The primary endpoint was proportion of patients achieving hematologic responses in ⩾1 lineage at week 18. Results: A total of 55 eligible patients were enrolled and received hetrombopag treatment. This study met its primary endpoint, with 23 [41.8%, 95% confidence interval (CI) = 28.7–55.9] patients achieving hematologic response in ⩾1 lineage at week 18 after initiation of hetrombopag treatment. Twenty-four (43.6%, 95% CI = 30.3–57.7) and 27 (49.1%, 95% CI = 35.4–62.9) of the 55 patients responded in ⩾1 lineage at weeks 24 and 52, respectively. Median time to initial hematologic response was 7.9 weeks (range = 2.0–32.1). The responses were durable, with a 12-month relapse-free survival rate of 82.2% (95% CI = 62.2–92.2). Adverse events occurred in 54 (98.2%) patients, and 28 (50.9%) patients had treatment-related adverse events. Seventeen (30.9%) patients had adverse events of grade ⩾3. Serious adverse events occurred in 15 (27.3%) patients and three deaths (5.5%) were reported. Conclusion: Hetrombopag showed encouraging efficacy with durable hematologic responses in patients with SAA who were refractory to IST. Hetrombopag was well tolerant and safe for long-term use. ClinicalTrials.gov identifier: NCT03557099
Prevention of puerperal sepsis in northwest Ethiopia: Knowledge and practice of postnatal women; A multicenter cross-sectional study
Authors: Bishaw Keralem Anteneh , Worku Shewangzaw , Tilahun Melkamu 
Published: March 2022

Objectives: Puerperal sepsis is a life-threatening condition that can lead to death and long-term morbidities of postnatal women, such as chronic pelvic pain, pelvic inflammatory disease, and secondary infertility. Therefore, the study aimed to assess the knowledge and practice of postnatal women at Debre Markos town health facilities toward the prevention of puerperal sepsis and its associated factors. Methods: A multicenter cross-sectional study was conducted from 1 to 30 July 2020. In all, 404 sampled postnatal women took part in the study. A systematic random sampling technique was employed to select each study participant. Data were entered into Epi data 4.6 and analyzed by statistical package for social sciences 25. Multivariate logistic regression was carried out for variables with a p value less than 0.25 in bivariate logistic regression to determine significant associations between the outcome and independent variables. The statistical significance was determined using a 95% confidence interval with a p value of less than 0.05. Results: The study reported that 44.6% and 40.8% of postnatal women had adequate knowledge, and good practice toward the prevention of puerperal sepsis, respectively. Factors associated with knowledge were urban residence [adjusted odds ratio = 5.84, 95% confidence interval = (3.54–9.46)], primiparity [adjusted odds ratio = 1.85, 95% confidence interval = (1.19–2.89)], and attending formal education [adjusted odds ratio = 2.41, 95% confidence interval = (1.11–5.22)] of study participants. Attending formal education [adjusted odds ratio = 2.46, 95% confidence interval = (1.13–5.37)] and having adequate knowledge [adjusted odds ratio = 2.34, 95% confidence interval = (1.49–3.67)] were factors associated with the prevention practice of postnatal women toward puerperal sepsis. Conclusion: Less than half of postnatal women had adequate knowledge and good practice to prevent puerperal sepsis. As a result, obstetric caregivers and other concerned bodies should consider strategies to increase the awareness level of women about puerperal sepsis. Interventions to improve the community’s educational level should also be considered.
Virtual Reality for Health Care Professionals During a Pandemic: A Pilot Program
Authors: Croghan Ivana T. , Hurt Ryan T. , Aakre Christopher A. , Fokken Shawn C. , Fischer Karen M. , Lindeen Stephanie A. , Schroeder Darrell R. , Ganesh Ravindra , Ghosh Karthik , Bauer Brent A. 
Published: March 2022

Objective: The purpose of this pilot study was to evaluate the safety and use of a nature-based virtual reality (VR) experience among health care providers (HCP) during a pandemic. Methods: Twenty-four frontline HCP participated in this crossover pilot where the viewing order of the experiences were randomized. All participants attended in-person consent, baseline, and end-of-study visits. The intervention consisted of viewing 2 nature-based scenes (“walk in the woods” and “forest of focus”) through 3-D VR and with computer 4K graphic imagery. Randomization took place with regards to the viewing order (VR vs 4K computer video, scene 1 and 2). Outcomes measured were safety, acceptability and changes in intensity of anxiety feelings, resilience, emotional distress, cognitive function, and self-efficacy. Results: Among the 26 HCP expressing interest in the study, 24 enrolled in this study. The majority were male (58.3%), white (66.7%) and of an average age of 46.3 ± 10.5 years (standard deviation (SD)). End of the study survey showed that almost all participants (96%) would participate in the study again and recommend it to others. Twenty-three of the 24 participants also felt relaxed after seeing the imagery. With respect to anxiety (as measured by the STAI Y1), the VR “walk in the woods” had the greatest reduction from pre to post (6.4 points, SD = 5.98) followed by VR “forest of focus” (5.8 points, SD = 9.29), computer screen “forest of focus” (5.0 points, SD = 8.89), and computer screen “walk in the woods” (4.1 points, SD = 6.22). All 4 sessions had a significant decrease in score from pre to post (P-values ≤.005), but there was no significant difference in the change from pre- to post-session between the 4 groups (P-value = .5835). Conclusion: The use of the VR among HCP has promise for reducing stress among health care providers during a high stress period, such as a pandemic but much larger studies are needed.
Improving Hearing Protection Device Noise Attenuation Through Fit-Testing in an Occupational Health Clinic
Authors: Hayes Melanie Ezell , Hammond Stephanie , Montgomery Aoyjai P. , Stephenson Laura 
Published: March 2022

Background: Occupational noise-induced hearing loss (NIHL) is the second most common medical disability for military veterans and accounts for 24% of all hearing loss in the United States. Hearing loss negatively affects health and billions of dollars are spent annually for direct and indirect medical costs and lost work productivity. Proper hearing protection device (HPD) fit can prevent NIHL. Quantitative fit-testing systems to determine personal attenuation rates (PARs) are available, but not widely utilized. Without quantitative testing, validating appropriate fit and attenuation to a permissible exposure level to prevent NIHL is difficult. Methods: A quality improvement project measured 100 employees enrolled in a hearing conservation program (HCP) to determine if they obtained a target PAR after inserting the HPDs in their “usual” fashion. Those who did not obtain target PAR ( n = 27) received an evidence-based intervention that demonstrated proper HPD fit by a skilled trainer followed by a repeat attempt by the participant to replicate the feel of the demonstrated HPD placement. PAR was subsequently measured to assess for appropriate noise attenuation. Findings: Seventy-one percent achieved target PAR (≥ 20 decibels) at baseline testing. After the intervention, 91 of 100 participants had achieved target PAR, a 20% improvement. Conclusions/Implications for Practice: Findings suggest this evidence-based intervention was an effective strategy for improving HPD fit for employees enrolled in HCPs. This intervention may prevent occupational hearing loss and decrease the health and socioeconomic impacts of NIHL.
Linking Problems Reported by Care Partners of Individuals With Alzheimer’s Disease and Lewy Body Dementia to the International Classification of Functioning Disability and Health
Authors: Kew Chung Lin , Juengst Shannon B. , Kelley Brendan , Osborne Candice L. 
Published: March 2022

Aim This study aims to classify, describe, and compare the problems reported by care partners of adults with Alzheimer’s disease (AD) and Lewy body dementia (LBD) using the International Classification of Functioning Disability and Health (ICF) Methods Problems that care partners experience were collected during a problem-solving training intervention. The meaningful concepts were then extracted and linked to the ICF using a standardized linking technique. Results 402 meaningful concepts were extracted from 128 problems reported by care partners. 79.4% of the concepts were linkable to the ICF. “Body functions” was most frequently addressed followed by “Activities and participation.” LBD care partners reported more problems (M = 23.6 ± 13.4) on average than AD care partners (M = 19.4 ± 12.1). LBD care partners reported greater relative proportions of problems in mental function (emotional and sleep functions) than AD care partners. Conclusion This study suggests that the experience of LBD care partners may include significantly more challenges and may be more emotionally demanding than the care experience of AD care partners. Interventions designed to support care partners of adults with dementia may need to be tailored to meet the needs of care partners based on the care receiver’s type of dementia.