bluuebunny/crossref_metadata_2025_split huggingface dataset:
830-P: The Pan-PPAR Agonist Lanifibranor Improves Nonalcoholic Steatohepatitis (NASH) and Glycemic Control
Authors: COOREMAN MICHAEL P. , FRANCQUE SVEN , DZEN LUCILE , HUOT-MARCHAND PHILIPPE , JUNIEN JEAN L. , BROQUA PIERRE , ABDELMALEK MANAL F. 
Published: May 2022

Lanifibranor therapy resulted in both NASH resolution and fibrosis reduction in the phase 2b NATIVE study in patients with non-cirrhotic NASH, compared to placebo. PPAR signaling is involved in common pathways of NASH and type 2 diabetes (T2D) . We evaluated the association between the effect of lanifibranor on glycemic control (GC) and NASH markers.
Methods: NATIVE included 247 patients, randomized to lanifibranor 800, 1200 mg/d or placebo for 24 weeks of treatment; 228 patients completed the trial. Efficacy in NASH was measured with SAF score (primary endpoint) and NASH-CRN grading and fibrosis staging. Biomarkers for insulin resistance (IR) , GC, lipid metabolism, inflammation, liver enzymes and imaging of hepatic steatosis by continuous attenuation parameter (CAP) were analyzed at baseline (BL) and end of treatment (EOT) . Correlations between HbA1c (≤6, &gt;6 - ≤7 and &gt;7%) at BL and HbA1c change from BL to EOT with improvement in biomarkers and histologic features of NASH at EOT were assessed.
Results: T2D was present in 103 (42%) patients. The composite endpoint of NASH resolution and fibrosis improvement in the overall and T2D group for lanifibranor (pooled data) versus (vs) placebo was 26% vs. 7% (p&lt;0.001) , and 26% vs. 3% (p=0.003) , respectively. Irrespective of T2D status, lanifibranor improved fasting glucose (FG) , IR, lipid metabolism, C-reactive protein, and liver enzymes. In contrast to placebo, lanifibranor improved mean HbA1c from BL in the overall and T2D group, -0.41% and -0.66%, respectively. In the lanifibranor group, BL HbA1c correlated with BL NASH activity and fibrosis; HbA1c decrease at EOT correlated with improvement of FG, insulin, IR, liver enzymes, HDL-cholesterol, triglycerides, ApoB, ApoB/ApoA1, CAP and histologic improvement of steatosis and ballooning.
Conclusion: GC correlates with NASH severity. The improvement of metabolic markers of NASH and hepatic steatosis with lanifibranor treatment is consistent with its beneficial effect on GC.

Disclosure
M.P.Cooreman: Employee; Inventiva Pharma. S.Francque: None. L.Dzen: Employee; Inventiva Pharma. P.Huot-marchand: Employee; Inventiva Pharma. J.L.Junien: None. P.Broqua: None. M.F.Abdelmalek: Advisory Panel; Akero Therapeutics, Inc., Bristol-Myers Squibb Company, Inventiva Pharma, Madrigal Pharmaceuticals, Inc., NGM Biopharmaceuticals, Novo Nordisk, Consultant; Hanmi Pharm. Co., Ltd., Research Support; Akero Therapeutics, Inc., Allergan, Boehringer Ingelheim International GmbH, Bristol-Myers Squibb Company, Celgene, DURECT Corporation, Enanta, Enyo Pharma, Hanmi Pharm. Co., Ltd., Intercept Pharmaceuticals, Inc., Inventiva Pharma, Madrigal Pharmaceuticals, Inc., NGM Biopharmaceuticals, Novo Nordisk, Poxel SA, TARGET PharmaSolutions, Inc., Viking Therapeutics.
878-P: Maximize Benefits of SGLT2 Inhibitors in People with Advanced CKD Stages with Type 2 Diabetes
Authors: KASHIMA KOJI , SHIMIZU HIROYUKI , YAMADA MASANOBU 
Published: May 2022

Objective: SGLT2 inhibitor (SGLT2i) should be considered for people with CKD with type 2 diabetes (T2D) . Since eGFR declining speed and responsiveness to SGLT2i are different in each person, we assessed renal protective effects by individual eGFR slope analysis.
Methods: A total of 75 patients with T2D with advanced CKD stage 3-4, treated by SGLT2i (empagliflozin 65% and others) were analyzed. The duration of diabetes at the time of recruitment were as follows: stage 3a (n=29) ; 11.9±5.4, stage 3b (n=28) ; 19.9±12.1, and stage 4 (n=18) ; 13.8±8.5 years. The mean of age was 70.3±12.2 year-old. GLP-1RAs was used in 41%, 64% and 44% respectively. Most rapid baseline eGFR slopes were calculated from 45.7±19.9 months before using SGLT2i, and slopes after adding SGLT2i were calculated from 39.2±11.4 months.
Results: 1) In total, the initiation of SGLT2i decreased eGFR from 46.1±14.1 to 43.6±13.5ml/min/1.73m2 (P&lt;0.001) on the first month. 2) In total, averaged individualized eGFR slopes were improved from -6.4±9.1 to -1.5±3.2ml/min/1.73m2/year (P&lt;0.001) . The rate of responders (responder: defined as slope are attenuated vs. baseline) in each stage were as follows: stage 3a; (22/29) , stage 3b; (22/28) , stage 4; (16/18) . Slopes in responders (60/75) were improved as follows, -7.5±9.8 to -0.8±3.0 ml/min/1.73m2/year (P&lt;0.001) . Slopes in non-responders (15/75) were worsened as follows, -2.0±2.0 to -4.0±3.2ml/min/1.73m2/year (P&lt;0.001) . Although no clear background differences could be found, responders were more rapid eGFR decliners and highly had macro-albuminuria (53% vs. 33%) . 3) Slopes were improved in all stages, stage 3a: -4.1±3.7 to -1.2±3.2 (P&lt;0.001) and stage 3b; -4.9±3.7 to -1.3±3.1 (P&lt;0.001) , and stage 4; -12.4±16.3 to -2.0±3.6ml/min/1.73m2/year (P&lt;0.01) . In stage 4, nephrosis highly existed in 28% at the baseline.
Conclusion: To pursuit the renal benefits safely, especially starting SGLT2i in lower eGFR level in people with advanced CKD stages, individualized slope analysis is needed.

Disclosure
K.Kashima: None. H.Shimizu: None. M.Yamada: None.
947-P: Needs Assessment for a Collaborative Patient-Centered Digital Health Application for Pediatric Diabetes Care in British Columbia
Authors: ABDULHUSSEIN FATEMA S. , AMED SHAZHAN , PINKNEY SUSAN 
Published: May 2022

There has been a rapid rise in digital health applications to support diabetes self-management to improve patient-centered outcomes such as engagement and satisfaction. TrustSphere is a collaborative single point of access digital health application that has been developed using principles of co-creation and participatory design with health care providers (HCP) and patients/families. Our objective is to describe HCP perspectives on current challenges and ideas for digital application features. A survey was distributed to pediatric diabetes HCP across British Columbia, Canada (n=50; 36% diabetes nurse educators, 24% nursing support services, 18% pediatricians, 12% dietitians, 8% pediatric endocrinologists) . HCP identified access to mental health support (84%) , diabetes management technologies (53%) , clinical information (39%) , and support for diabetes care at school (35%) as key challenges. Qualitative data revealed struggles with staying up to date with diabetes technology and empowering patients to self-manage their diabetes between visits. HCP reported TrustSphere should include information on the type of insulin regimen (87%) , insulin doses & pump settings (76%) and patient-centered goals (41%) as well as integration of glucose meter (91%) , continuous glucose monitor (CGM) (93%) , and insulin pump data (91%) . Overall, HCP felt an integrated digital platform would greatly simplify their care for children with T1D (47%) . HCP perspectives were integrated into TrustSphere’s minimal viable product (MVP) . Via real-time connections, glucometer, CGM, and pump data have been integrated into the platform. Insulin doses, patient tasks, and management recommendations can be collaboratively entered by patients or HCP, optimizing personalized care. Educational resources and a mindfulness app to support mental health can also be accessed via TrustSphere. Next steps are a pilot study of the TrustSphere MVP with pediatric T1D patients.

Disclosure
F.S.Abdulhussein: None. S.Amed: Advisory Panel; Insulet Corporation, Lilly, Sanofi, Research Support; Dexcom, Inc., Novo Nordisk, Speaker's Bureau; Abbott Diabetes. S.Pinkney: None.

Funding
Canadian Digital TechnologySuperclusterUniversity of British Columbia
Peningkatan Kemampuan Pemecahan Masalah Matematik Berdasarkan Kecerdasan Emosional Siswa Melalui Pembelajaran Berbasis Masalah
Authors: Fuadi Diki Najib 
Published: May 2022

Tujuan penelitian adalah untuk mengetahui peningkatan kemampuan pemecahan masalah matematik dan dampaknya pada kecerdasan emosional siswa dalam pembelajaran matematika melalui metode pembelajaran masalah. Selain itu tujuan penelitian ini adalah untuk mengetahi aktifitas siswa dalam pembelajaran matematika deng mengguanakan metode pembelajaran berbasis masalah. Penelitian ini termasuk penelitian quasi eksperimen dan penelitian tindakan kelas (PTK) dengan desain kelompok kontrol tidak ekuivalen (the nonequivalent control design). Populasi dan sampel dalam penelitian ini adalah siswa MTs Negeri Mandalawangi, sampel sebanyak dua kelas yaitu VIII A sebagai kelas eksperimen sebanyak 30 siswa dan kelas VIII B sebagai kelas kontrol sebanyak 30 siswa. Insnstrumen tes berupa soal-soal yang digunakan untuk mengukur kemampuan pemecahan masalah matematik siswa. Hasil penelitian menunjukan bahwa; 1) Pembelajaran berbasis masalah dapat meningkatkan kemampuan pemecahan masalah matematik; 2) Peningkatan kemampuan pemecahan masalah matematik siswa yang kecerdasan emosional tinggi dan rendah menggunakan pembelajaran berbasis masalah lebih baik dibandingkan dengan siswa yang menggunakan pembelajaran konvensional; 3) Terdapat korelasi antara kemampuan pemecahan masalah matematika dan kecerdasan emosinal siswa; 4) Aktivitas siswa meningkat dalam pembelajaran matematika dengan menggunakan pembelajaran berbasis masalah
Penerapan Model Pembelajaran Kooperatif Tipe Numbered Head Together (Nht) Terhadap Kemampuan Pemahaman Matematis Dan Kemampuan Komunikasi Matematis Siswa Smp
Authors: Wardhani Santi Sri 
Published: May 2022

Penelitian ini mengkaji tentang, Peningkatan Kemampuan Pemahaman Matematis dan Kemampuan Komunikasi Matematis dan perbedaan antara siswa yang menerapkan Model Pembelajaran Kooperatif Tipe Numbered Head Together (NHT) dengan siswa yang memperoleh model pembelajaran konvensional, ditinjau dari kategori kemampuan pemahaman matematis dan komunikasi matematis (gender dan keseluruhan) serta hubungan kemampuan pemahaman matematis dan kemampuan komunikasi matematis siswa. Metode yang digunakan pada penelitian ini adalah mixed methods tipe embedded. Sampel yang digunakan adalah dua kelas dari delapan kelas yang ada. Hasil penelitian menunjukkan bahwa 1) Peningkatan kemampuan pemahaman dan komunikasi matematis siswa yang menerapkan Model Pembelajaran Numbered Head Together (NHT) lebih baik daripada siswa yang menggunakan model pembelajaran konvesional dari kategori keseluruhan. 2) untuk kategori gender, peningkatan kemampuan pemahaman dan komunikasi matematis siswa laki-laki yang menerapkan Model Pembelajaran Numbered Head Together (NHT) tidak lebih baik daripada siswa laki-laki yang menggunakan model pembelajaran konvesional. 3) Tidak terdapat hubungan antara kemampuan pemahaman matematis dan kemampuan komunikasi matematis.
Penggunaan Pembelajaran Dengan Pendekatan Brain Based Learning Terhadap Peningkatan Kemampuan Berpikir Kritis Matematis
Authors: Jauhari Afifah Latip Rasyid 
Published: May 2022

Latar belakang masalah pada penelitian ini adalah kemampuan berpikir kritis matematis di Indonesia yang masih tergolong sangat rendah atau dibawah rata-rata. Diprediksi bahwa pembelajaran dengan pendekatan BBL dapat membantu siswa mempengaruhi kemampuan berpikir kritis matematis. Tujuan penelitian ini adalah: 1) Menganalisis perbedaan peningkatan kemampuan berpikir kritis matematis siswa yang menggunakan pembelajaran dengan pendekatan BBL dan pembelajaran konvensional ditinjau dari keseluruhan dan perbedaan gender; 2)Melihat aktivitas siswa terhadap respon pembelajaran matematika dengan pendekatan BBL. Metode penelitian yang akan digunakan dalam penelitian ini merupakan Metode Campuran (Mixed Method) tipe Embedded Design dengan jenis Embedded Experimental Model. pengambilan sampel menggunakan teknik purposive sampling, sampel yang terpilih adalah kelas VIII-E sebagai kelas ekserimen dan kelas VIII-B sebagai kelas kontrol. Instrumen yang digunakan pada penelitian ini adalah instrumen tes yaitu tes kemampuan berpikir kritis matematis dan instrumen non tes yaitu lembar observasi. Pokok bahasan yang disajikan sebagai bahan materi adalah SPLDV. Hasil penelitian ini adalah: (1) Kemampuan berpikir kritis matematis siswa yang menggunakan pembelajaran dengan pendekatan BBL lebih baik dari pada siswa yang menggunakan pembelajaran konvensional ditinjau dari keseluruhan dan perbedaan gender, (2) 2) Dalam pembelajaran dengan pendekatan Brain based learning siswa terlihat aktif dalam pembelajaran matematika.
Penerapan Assesmen kinerja dalam Pembelajaran Berbasis Masalah untuk meningkatkan pemahaman konsep dan kemampuan pemecahan masalah matematis pada peserta didik SMP.
Authors: Yulianingsih Yulianingsih 
Published: May 2022

Penelitian ini dilatarbelakangi oleh rendahnya pemahaman konsep dan kemampuan pemecahan masalah matematis peserta didik SMP. Tujuan penelitian ini adalah: 1) untuk mengetahui apakah peserta didik siswa yang mendapat pembelajaran matematika berbasis masalah dengan menggunakan assesmen kinerja mendapat peningkatan pemahaman konsep dan kemampuan pemecahan masalah lebih baik daripada siswa yang mendapat pembelajaran matematika dengan pembelajaran ekspositori; 2) Untuk mengetahui bagaimana sikap siswa terhadap pembelajaran matematika dengan penerapan assesmen kinerja dan model pembelajaran berbasis masalah. Penelitian ini menggunakan metode eksperimen, sedangkan populasi dalam penelitian ini adalah seluruh siswa kelas VII SMP Negeri 1 Sumber Kab Cirebon tahun pelajaran 2013/2014. Instrumen penelitian yang digunakan berupa instrumen tes dan non-tes. Instrumen tes berupa soal pilihan ganda dan uraian berdasarkan indikator pemahaman konsep dan kemampuan pemecahan masalah matematik dan instrumen non-tes berupa angket dan lembar observasi assesmen kinerja. Hasil penelitian menunjukkan bahwa: 1) Siswa yang mendapat pembelajaran matematika dengan penerapan Assesmen kinerja dalam Pembelajaran Berbasis Masalah peningkatan pemahaman konsep dan kemampuan pemecahan masalah matematiknya lebih baik daripada siswa yang mendapat pembelajaran matematika dengan pendekatan ekspositori; 2) Hampir seluruh siswa menunjukkan sikap positif terhadap pembelajaran matematika,Pembelajaran Berbasis masalah dan pemecahan masalah.
Implementasi E-learning untuk Mengembangkan self efficacy siswa
Authors: Wahyudin Yudin , Mubarika Melinda Putri , Firmansyah Eka 
Published: May 2022

Untuk menjawab tuntutan dunia pendidikan saat ini, model pembelajaran E-Learning merupakan salah satu model pembelajaran dengan memanfaatkan perkembangan teknologi informasi dan komunikasi. Penelitian ini berfokus pada pengaruh model pembelajaran E-Learning yang diduga dapat mengembangkan keyakinan (self-efficacy). Penelitian ini dilakukan dengan menggunakan metode campuran triangulasi (mixed methode triangulasi), dalam strategi ini peneliti mengumpulkan data kuantitatif dan data kualitatif secara konkruen (dalam satu waktu). Sampel penelitiannya siswa-siswi kelas XI MIA 7 dan kelas XI MIA 8 SMAN 8 Bandung. Hasil penelitian: 1) Self Efficacy siswa yang memperoleh model Pembelajaran e-learning tidak lebih baik atau relative sama dibandingkan dengan Self Efficacy siswa yang memperoleh pembelajaran konvensional, 2) Faktor-faktor yang dapat meningkatkan self eficacy siswa dengan pembelajaran e-learning menurut pendapat siswa adalah : motivasi diri siswa, suasana pembelajaran yang menyenangkan, fasilitas yang memadai dan sikap guru yang menyenangkan.
Trailing Stop-Loss and Re-Entry Strategies in Europe
Authors: Duarte Elisabete 
Published: May 2022

A stop-loss order is a method that can be used by investors to limit downside risk and can be explained by investors’ loss aversion. Loss aversion refers to the widely studied psychological phenomenon where expected losses have a greater impact on the investors’ preferences than expected gains. The use of stop-loss rules allows for this asymmetric profile. The stop loss hypothesis, also, states that higher returns can be obtained by limiting the downside risk of long positions. A stop-loss order can be established at a percentage of the asset value that grows over time as it rises, stopping if the asset value starts to go down (trailing stop-loss order). In this work, it is used trailing stop-loss orders (with a difference to the asset market value of 3%) with long positions in financial markets. After being stopped out in a down market, the re-entry rule is to buy the asset again as soon as the market grows by at least 3%. Whenever the portfolio is sold out by applying the trailing stop-loss rule, the investment is held in cash until the trigger is set off. In this article the rules are applied in Germany, France, Spain, and Greece during the financial crisis, to make an empirical validation of trailing stop-loss rules and re-entry rules for these markets. It was found that the followed strategy presents mixed results, proving to beat the buy-and-hold strategy in some scenarios of rising and falling prices. But the most important result is to generate fewer losses in very volatile scenarios such as Greece in 2014.
Predicting major events in ambulatory patients with advanced heart failure awaiting heart transplantation: a pilot study
Authors: Palmieri Vittorio , Amarelli Cristiano , Mattucci Irene , Bigazzi Maurizio Cappelli , Cacciatore Francesco , Maiello Ciro , Golino Paolo 
Published: May 2022

Aims
In heart failure (HF), prognostic risk scores focus on all-cause mortality prediction. However, in advanced HF (AdHF) ambulatory patients awaiting heart transplantation (HTx), hospitalizations for acutely decompensated/worsening HF are relevant to clinical decision-making, but unpredicted by common risk functions.

Methods
Among consecutive ambulatory patients added to the waitlist for HTx, event discriminators within 2 years from recruitment were assessed prospectively by area under the curve from receiver-operating characteristic curves, and by Cox proportional hazards models. Primary composite end points included the first between all-cause mortality and acutely decompensated/worsening HF requiring hospitalization and specific treatments.

Results
In 89 patients, 36 primary composite events were recorded in a 2-year follow-up (40% of the study sample), and associated with nonischemic etiology and nonsinus rhythm, with lower systolic blood pressure (BP), lower plasma sodium and hemoglobin concentrations, and with higher N-terminal pro-brain natriuretic peptide (NT-proBNP), larger left ventricular (LV) dimensions and lower LV ejection fraction, greater proportion of significant mitral regurgitation, lower tricuspid annulus peak systolic excursion (TAPSE), lower percentage of predicted distance at 6-minute walking test (%p6MWT) and lower global symptoms burden by the Kansas City Cardiomyopathy Questionnaire, lower peak oxygen uptake by cardiopulmonary exercise, and higher wedge pressure by right heart catheterization, as compared with those with no events (P < 0.05). Only Metabolic Exercise Cardiac Kidney Index (MECKI) at recruitment was higher with patients reporting events, which predicted composite end points in addition to and independently of NT-proBNP, and lower systolic BP (all P < 0.05). In an alternative risk model, severe mitral regurgitation and lower TAPSE replaced MECKI and BP but not NT-proBNP (all P < 0.01).

Conclusion
Higher NT-pro-BNP, lower systolic BP and higher MECKI may contribute to predicting all-cause death and acutely decompensated/worsening HF among ambulatory patients awaiting HTx, with lower TAPSE and severe mitral regurgitation representing further alternative independent prognosticators.
Evaluation of robotic-assisted mitral surgery in a contemporary experience
Authors: Agnino Alfonso , Graniero Ascanio , Villari Nicola , Roscitano Claudio , Gerometta Piersilvio , Albano Giovanni , Anselmi Amedeo 
Published: May 2022

Aims
To evaluate the safety/effectiveness of a recently established robotic-assisted mitral surgery program.

Methods
Cohort study with prospective collection of clinical data of 59 consecutive recipients (May 2019–August 2021) of robotic-assisted (fourth-generation platform, DaVinci X) mitral valve repair for degenerative disease, using a totally endoscopic technique. Patients’ selection was based on defined anatomical and clinical criteria. We established a dedicated multidisciplinary protocol to facilitate postoperative fast-tracking, and a systematic in-house clinical and echocardiographic follow-up at 3, 6, and 12 postoperative months.

Results
All patients (89.8% men, average age 58 ± 12 years) received mitral valve repair; there was no operative mortality, one conversion to sternotomy (1.7%) and one stroke (1.7%). Extubation within the operative theater occurred in 28.8%; average mechanical ventilation time and ICU stay was 2.8 ± 4.1 and 32.5 ± 15.8 h (after exclusion of one outlier, learning-curve period, suffering from perioperative stroke); average postoperative hospital stay was 6.8 ± 3.4 days and 96.6% of patients were discharged home. One patient was transfused (1.7%); there were no other complications. Follow-up revealed stability of the results of mitral repair, with one (1.7%) persistent (>2+/4+) mitral regurgitation, and stability of coaptation height over time. We observed optimal functional results (class I was 98% at 3 months and 96% at 12 months). Quarterly case load consistently increased during the experience.

Conclusion
This initial experience suggests the reliability and clinical safety of a recently established local robotic-assisted mitral surgery. This strategy can facilitate faster postoperative recovery, and its positioning in the therapeutic armamentarium needs to be defined.
Reading and Mapping the Worldviews of Island States through National Anthems: Celebrating Deity, Identity, Landscapes and Unity
Authors: Brunn Stanley D. 
Published: May 2022

Abstract
National anthems, along with the national flag, stamps and monuments, are important features of a state’s identity. The lyrics and music instill patriotism and nationalism on holidays, at sporting events, and in children at school. This study examines the lyrics of 42 Caribbean, Pacific, African, Asian and European island state anthems to identify patterns and themes. While word frequencies differ between the regions, dominant themes reflect unity, hope, a spiritual/divine heritage, home and homeland, and pleasant environmental settings. Themes reflecting times of strife, struggles and conflict are also evident.
RELATION OF POWER-KNOWLEDGE IN BALI MANDARA DISCOURSE
Authors: Al Jundi Fauzan , Ardhana I Ketut , Suarka I Nyoman 
Published: May 2022

Bali has great potentials in its beautiful nature and unique culture, which the government uses as an opportunity to implement regional development using the concept of Bali Mandara. This study aims to find out why the development of Bali province applying the concepts of Bali Mandara becomes a polemic for some Balinese, the existence of a power-knowledge relation in the concept of Bali Mandara discourse, and the implications of the development process implementing the Bali Mandara program. The data were analyzed using power-knowledge relation theory and generative structure. The results showed pros and cons in the planning and implementation of the development of the Bali Province. The rules and policies arranged in Regional Regulations (Perda) to support Bali's development are power-knowledge relations that the government applies to achieve the goals. Bali Mandara program has been implemented in less than a decade. Various benefits are the fundamental basis for the readiness of the Balinese to face a better future.
Keywords: Bali Mandara, Discourse, Relation, Power-Knowledge.