bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostics and Health Management of Wind Energy Infrastructure
Systems
Authors: Yüce Celalettin , Gecgel Ozhan , Doğan Oğuz , Dabetwar Shweta , Yanik Yasar , Kalay Onur Can , Karpat Esin , Karpat Fatih , Ekwaro-Osire Stephen 
Published: January 2022

Abstract
The improvements in wind energy infrastructure have been a constant process throughout many decades. There are new advancements in technology that can further contribute toward the prognostics and health management (PHM) in this industry. These advancements are driven by the need to fully explore the impact of uncertainty, quality and quantity of data, physics-based machine learning (PBML), and digital twin (DT). All these aspects need to be taken into consideration to perform an effective PHM of wind energy infrastructure. To address these aspects, four research questions were formulated. What is the role of uncertainty in machine learning (ML) in diagnostics and prognostics? What is the role of data augmentation and quality of data for ML? What is the role of PBML? What is the role of the DT in diagnostics and prognostics? The methodology used was Preferred Reporting Items for Systematic Review and Meta-Analysis. A total of 143 records, from the last five years, were analyzed. Each of the four questions was answered by discussion of literature, definitions, critical aspects, benefits and challenges, the role of aspect in PHM of wind energy infrastructure systems, and conclusion.
Morphological and molecular analysis of Ornithodoros hasei and Ornithodoros sp. cf. O. mimon (Acari: Argasidae) from northeastern Argentina
Authors: Benedetto Ingrid M. D. Di , Debarbora Valeria N. , Ibalo Alicia P. Benitez , Oscherov Elena B. , Autino Analía G. , Nava Santiago , Venzal José M. 
Published: January 2022

In this study two species of soft ticks belonging to the genus Ornithodoros were recorded in three areas in the province of Corrientes, Argentina. Four larvae were identified as Ornithodoros hasei (Schulze, 1935) on Molossus molossus (Molossidae) in Paraje Tres Cerros (Department of San Martín), while 56 larvae were identified as Ornithodoros sp. cf. O. mimon Kohls, Clifford & Jones, 1969 on Eptesicus furinalis and Myotis levis (Vespertilionidae) in Paraje Galarza (Department of Santo Tomé) and Colonia Carlos Pellegrini (Department of San Martín). These last two locations are found within the Esteros del Iberá eco-region. The known distribution range of O. hasei and O. cf. O. mimon is expanded to include the province of Corrientes. Two new ectoparasite-host associations were recorded for Argentina between O. hasei on M. molossus and O. cf. O. mimon on M. levis. The morphological differences together with the results of the phylogenetic analysis show that O. hasei presents genetic similarity with specimens from Brazil, and in Argentina, with ticks from Santa Fe. Instead, Ornithodoros sp. cf. O. mimon recorded in Corrientes and Uruguay belong to a different taxon than the O. mimon recorded in Brazil and Santa Fe, Argentina. Based on this, O. mimon should be considered a complex of species in which the specimens from Corrientes are provisionally considered as Ornithodoros sp. cf. O. mimon until their taxonomic status can be determined.
Effects of Knowledge of Results and Change-Oriented Feedback on Swimming Performance
Authors: Doma Kenji , Engel Alexander , Connor Jonathan , Gahreman Daniel 
Published: January 2022

Purpose: This study examined the effect of providing knowledge of results (KR) with, and without, promotion- and change-oriented feedback on repeated-sprint ability in swimmers. Methods: Twenty-nine male and female swimmers (age = 16 [1] y, height = 1.74 [0.07] m, body mass = 61.0 [8.4] kg) were randomly allocated into 2 different feedback conditions, or a condition without feedback (NoFb), as a crossover, repeated-measures design. In one feedback condition, the swimmers were provided with lap completion times as KR. The other feedback condition was athlete-driven, where the swimmers were asked to estimate their lap completion times, and the investigators responded on whether their actual sprint times were faster (promotion-oriented), slower (change-oriented), or the same. Results: The results showed significantly faster average completion times during the repeated-sprint swim protocol in the athlete-driven KR (P = .014) and KR condition (P = .023), when compared with the NoFb condition. However, significantly faster best completion time was only found in the KR condition (P = .012), when compared with the NoFb condition. Furthermore, the stroke rate was significantly greater during the athlete-driven KR (P = .009) and KR (P = .021) conditions, when compared with the NoFb condition. Conclusions: The KR condition exhibited the greatest benefit for improving several swimming performance measures during a repeated-sprint protocol, and the increase in stroke rate may have contributed to this performance enhancement. Thus, it is recommended that swimmers receive lap completion times during repeated-sprint training sessions to optimize training quality.
ADG: automated generation and evaluation of many-body diagrams
Authors: Tichai A. , Arthuis P. , Hergert H. , Duguet T. 
Published: January 2022

AbstractThe goal of the present paper is twofold. First, a novel expansion many-body method applicable to superfluid open-shell nuclei, the so-called Bogoliubov in-medium similarity renormalization group (BIMSRG) theory, is formulated. This generalization of standard single-reference IMSRG theory for closed-shell systems parallels the recent extensions of coupled cluster, self-consistent Green’s function or many-body perturbation theory. Within the realm of IMSRG theories, BIMSRG provides an interesting alternative to the already existing multi-reference IMSRG (MR-IMSRG) method applicable to open-shell nuclei. The algebraic equations for low-order approximations, i.e., BIMSRG(1) and BIMSRG(2), can be derived manually without much difficulty. However, such a methodology becomes already impractical and error prone for the derivation of the BIMSRG(3) equations, which are eventually needed to reach high accuracy. Based on a diagrammatic formulation of BIMSRG theory, the second objective of the present paper is thus to describe the third version (v3.0) of the code that automatically (1) generates all valid BIMSRG(n) diagrams and (2) evaluates their algebraic expressions in a matter of seconds. This is achieved in such a way that equations can easily be retrieved for both the flow equation and the Magnus expansion formulations of BIMSRG. Expanding on this work, the first future objective is to numerically implement BIMSRG(2) (eventually BIMSRG(3)) equations and perform ab initio calculations of mid-mass open-shell nuclei.
Observações prévias sobre a malacofauna em alguns pequenos sambaquis do litoral sul de Santa Catarina
Authors: Heitzmann-Fontenelle José , Tognoli Anderson Rogério de Oliveira , Demathe Alexandro 
Published: January 2022

Foi realizada a análise da malacofauna presente em seis pequenos sambaquis localizados em Jaguaruna-SC com idades entre 3080 e 580 anos AP (Eliza, Encruzo, Campo Bom I, Campo Bom II, Campo Bom III e Arroio da Cruz I). Foram identificadas 24 espécies de moluscos sendo 10 gastrópodes e 12 bivalves. pertencentes a 6 e 10 famílias respectivamente. Todas as espécies eram de ambiente marinho ou estuarino com exceção de duas espécies do caracol terrestre Megalobulimus. Constatou-se a existência de dois padrões distintos quanto à constituição da matriz malacológica dos sítios. Nos sambaquis mais antigos (Eliza e Encruzo) havia maior diversidade de espécies sendo a maioria procedentes de um paleoambiente lagunar e estuarino (Anomalocardia brasiliana, Phacoides pectinatus e Erodona mactroides) incluindo manguezal (Cassostrea brasiliana), com grande variação no tamanho intraespecífico e a ocorrência de indivíduos íntegros com as valvas fechadas. Nos sambaquis com datações mais recentes (Campo Bom I, II e III, e Arroio da Cruz I) havia a presença majoritária de espécies do litoral de mar aberto (Mesodesma mactroides e Donax hanleyanus) com maior uniformidade intraespecífica no tamanho, sendo que a matrix malacológica do Campo Bom II diferenciou-se pela ocorrência adicional de grandes indivíduos do bivalve Tivela zonaria e do gastrópode Pachycymbiola brasiliana, inferindo uma construção diferenciada. Este estudo reforçou a importância da avaliação da matriz malacológica em sambaquis como indicativo do paleoambiente e das opções culturais de seus construtores, bem como que a diversidade de espécies poderia sugerir um uso ou função distinta do sítio.
Comparative Studies of Renin-Null Zebrafish and Mice Provide New Functional Insights
Authors: Hoffmann Scott , Mullins Linda , Rider Sebastien , Brown Cara , Buckley Charlotte B. , Assmus Adrienne , Li Ziwen , Sierra Beltran Mariana , Henderson Neil , del Pozo Jorge , De Goes Martini Alexandre , Sequeira-Lopez Maria Luisa S. , Gomez R. Ariel , Mullins John 
Published: January 2022

Background:
The renin-angiotensin system is highly conserved across vertebrates, including zebrafish, which possess orthologous genes coding for renin-angiotensin system proteins, and specialized mural cells of the kidney arterioles, capable of synthesising and secreting renin.

Methods:

We generated zebrafish with CRISPR-Cas9-targeted knockout of renin (
ren
−/−
) to investigate renin function in a low blood pressure environment. We used single-cell (10×) RNA sequencing analysis to compare the transcriptome profiles of renin lineage cells from mesonephric kidneys of
ren
−/−
with
ren
+/+
zebrafish and with the metanephric kidneys of
Ren1

c
−/−

and
Ren1

c
+/+

mice.

Results:

The
ren
−/−
larvae exhibited delays in larval growth, glomerular fusion and appearance of a swim bladder, but were viable and withstood low salinity during early larval stages. Optogenetic ablation of renin-expressing cells, located at the anterior mesenteric artery of 3-day-old larvae, caused a loss of tone, due to diminished contractility. The
ren
−/−
mesonephric kidney exhibited vacuolated cells in the proximal tubule, which were also observed in
Ren1

c
−/−

mouse kidney. Fluorescent reporters for renin and smooth muscle actin (
Tg(ren:LifeAct-RFP; acta2:EGFP
)), revealed a dramatic recruitment of renin lineage cells along the renal vasculature of adult
ren
−/−
fish, suggesting a continued requirement for renin, in the absence of detectable angiotensin metabolites, as seen in the
Ren1
YFP
Ren1

c
−/−

mouse. Both phenotypes were rescued by alleles lacking the potential for glycosylation at exon 2, suggesting that glycosylation is not essential for normal physiological function.

Conclusions:
Phenotypic similarities and transcriptional variations between mouse and zebrafish renin knockouts suggests evolution of renin cell function with terrestrial survival.
Unconventional Monetary Policy through Open Market Operations: A Principal Component Analysis
Authors: Heckel Markus , Nishimura Kiyohiko G. 
Published: January 2022

Abstract
This paper examines the unconventional monetary policies of the Bank of Japan from 2002 to 2019 with a focus on open market operations.  We apply a principal component analysis to investigate the complexity of monetary policy.  Our results identify four principal components that explain the variance of measures taken by the Bank of Japan and its operations of various facilities: asset purchase measures including Japanese Government Bonds (JGBs), Exchange-Traded Funds (ETFs), Japanese Real Estate Investment Trusts (J-REITs), and three different liquidity supply measures. Complexity differs substantially among different governorships of Fukui, Shirakawa (most complex), and Kuroda. We derive some conclusions from the increased complexity with implications for the economy.
Expended range of Gomphonema firmum (Bacillariophyceae), once considered a Lake Baikal endemic, with notes on the identity of G.&nbsp;lanceolatum var. maximum
Authors: VISHNYAKOV VASILY S. 
Published: January 2022

This note describes a new record of Gomphonema firmum Skvortzow, which expanded both morphological and distributional ranges of the species. This conspicuous diatom was previously unknown outside of Lake Baikal, where it inhabits deep-water areas. The newly discovered locality belongs to a small stream at a distance of 180 km west from Lake Baikal, where the species was found in a relatively high abundance that enabled to trace a size diminution series including specimens shorter than previously described. In addition, G. lanceolatum var. maximum Poretzky, a name for a diatom from Lake Teletskoe, was included in a synonymy of G. firmum that further expanded the species distribution. In the light of the presented data, the species appears to be a rare diatom with current distribution limited to a few scattered localities in southern Siberia.
Who operates on the children?
Authors: Mlay K , Hampton T , Sharma R , Howard D , Chussi D , Shija P 
Published: January 2022

An unexpectedly high burden of elective paediatric surgery is being performed by the Ear, Nose and Throat (ENT) surgeons in Moshi, Tanzania. We believe this brief survey demonstrates the capacity for elective paediatric surgery in the sub-Saharan setting, comparable to the elective operative numbers of an equivalent tertiary centre in Liverpool, UK.
Serum exosomal miR-451a acts as a candidate marker for pancreatic cancer
Authors: Chen Jia , Yao Dongting , Chen Weiqin , Li Zhen , Guo Yuanyuan , Zhu Fan , Hu Xiaobo 
Published: January 2022

Objectives The aim of this study was to explore the diagnostic efficiency of serum exosomal miR-451a as a novel biomarker for pancreatic cancer. Methods Serum samples were collected prior to treatment. First, we analyzed microRNA (miRNA) profiles in serum exosomes from eight pancreatic cancer patients and eight healthy volunteers. We then validated the usefulness of the selected exosomal miRNAs as biomarkers in another 191 pancreatic cancer patients, 95 pancreatic benign disease (PB) patients, and 90 healthy controls. Results The expression of miR-451a in serum-derived exosomes from pancreatic cancer patients was significantly upregulated compared with those from PB patients and healthy individuals. Serum exosomal miR-451a showed excellent diagnostic power in identifying pancreatic cancer patients. In addition, exosomal miR-451a showed a significant association with clinical stage and distant metastasis in pancreatic cancer, and the expression level of serum exosomal miR-451a was sensitive to therapy and relapse. Conclusions Serum exosomal miR-451a might serve as a novel diagnostic marker for pancreatic cancer.
RNA sequencing of chronic GVHD skin lesions defines shared and unique inflammatory pathways characterizing lichen planus and morphea
Authors: Zouali Habib , Lemasson Juliette , Calugareanu Andreea , Battail Christophe , Michonneau David , le Buanec Hélène , Grolleau Chloé , Cassius Charles , Robin Marie , Merandet Marine , Dobos Gabor , Mahevas Thibault , Rybojad Michel , de Masson Adèle , Amode Reyhan , Boland Anne , Michel Laurence , Sicre de Fontbrune Flore , Peffault de Latour Régis , Bruneval Patrick , Ait-Oufella Hafid , Battistella Maxime , Jachiet Marie , Bagot Martine , Deleuze Jean-François , Socié Gérard , Bouaziz Jean-David 
Published: January 2022

Abstract
Cutaneous involvement of chronic graft-versus-host disease (cGVHD) has a wide range of manifestations including a lichenoid form with a currently assumed mixed Th1/Th17 signature and a sclerotic form with Th1 signature. Despite substantial heterogeneity of innate and adaptive immune cells recruited to the skin and of the different clinical manifestations, treatment depends mainly on the severity of the skin involvement and relies on systemic, high-dose glucocorticoids alone or in combination with a calcineurin inhibitor. We performed the first study using RNA sequencing to profile and compare the transcriptome of lichen planus cGVHD (n = 8), morphea cGVHD (n = 5), and healthy controls (n = 6). Our findings revealed shared and unique inflammatory pathways to each cGVHD subtype that are both pathogenic and targetable. In particular, the deregulation of IFN signaling pathway was strongly associated with cutaneous cGVHD, whereas the triggering receptor expressed on myeloid cells 1 pathway was found to be specific of lichen planus and likely contributes to its pathogenesis. The results were confirmed at a protein level by performing immunohistochemistry staining and at a transcriptomic level using real-time quantitative polymerase chain reaction.
Prevalence and variation of CHIP in patients with aggressive lymphomas undergoing CD19-directed CAR T-cell treatment
Authors: Teipel Raphael , Kroschinsky Frank , Kramer Michael , Kretschmann Theresa , Egger-Heidrich Katharina , Krüger Thomas , Ruhnke Leo , Herold Sylvia , Stasik Sebastian , Sockel Katja , Middeke Jan M. , Trautmann-Grill Karolin , Bornhäuser Martin , Thiede Christian , von Bonin Malte 
Published: January 2022

Abstract
Inflammation plays an important role in chimeric antigen receptor (CAR) T-cell therapy, especially in the pathophysiology of cytokine-release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS). Clonal hematopoiesis of indetermined potential (CHIP) has also been associated with chronic inflammation. The relevance of CHIP in the context of CAR T-cell treatment is widely unknown. We evaluated the prevalence of CHIP, using a targeted deep sequencing approach, in a cohort of patients with relapsed/refractory (r/r) B-cell non-Hodgkin lymphoma before and after CAR T-cell treatment. The aim was to define the prevalence and variation of CHIP over time and to assess the influence on clinical inflammation syndromes (CRS/ICANS), cytopenia, and outcome. Overall, 32 patients were included. CHIP was found in 11 of 32 patients (34%) before CAR T-cell therapy. CHIP progression was commonly detected in the later course. Patients with CHIP showed a comparable response rate to CAR T-cell treatment but had an improved overall survival (not reached vs 265 days, P = .003). No significant difference was observed in terms of the occurrence and severity of CRS/ICANS, therapeutic use of tocilizumab and glucocorticosteroids, paraclinical markers of inflammation (with the exception of ferritin), or dynamics of hematopoietic recovery. CHIP is commonly observed in patients undergoing CD19-directed CAR T-cell therapy and is not associated with an inferior outcome.
Impact of environmental factors on human semen quality and male fertility: a narrative review
Authors: Kumar Naina , Singh Amit Kant 
Published: January 2022

Abstract
Background
Worldwide rising trend in infertility has been observed in the past few years with male infertility arising as a major problem. One main reason for the rise in male infertility cases is declining semen quality. It was found that any factor that affects semen quality can affect male fertility. There are several modifiable factors affecting semen quality including air pollution, use of pesticides and harmful chemicals, exposure to excessive heat, and can lead to decreased male fertility.

Main body
The present review focuses on some of these environmental factors that affect semen quality and hence, can cause male infertility. The literature from 2000 till June 2021 was searched from various English peer-reviewed journals and WHO fact sheets using the USA National Library of Medicine (PubMed) database, the regional portal of Virtual Health Library, and Scientific Electronic Library Online. The search terms used were: “Air pollution and male fertility”, “Chemicals and male infertility”, “Heat exposure and infertility”, “heavy metals and male fertility”.

Conclusion
Adverse environmental factors have a significant impact on semen quality, leading to decreased sperm concentration, total sperm count, motility, viability, and increased abnormal sperm morphology, sperm DNA fragmentation, ultimately causing male infertility. However, all these factors are modifiable and reversible, and hence, by mere changing of lifestyle, many of these risk factors can be avoided.
Polygenic risk prediction based on singular value decomposition with applications to alcohol use disorder
Authors: Yang James J. , Luo Xi , Trucco Elisa M. , Buu Anne 
Published: January 2022

AbstractBackground/aimThe polygenic risk score (PRS) shows promise as a potentially effective approach to summarize genetic risk for complex diseases such as alcohol use disorder that is influenced by a combination of multiple variants, each of which has a very small effect. Yet, conventional PRS methods tend to over-adjust confounding factors in the discovery sample and thus have low power to predict the phenotype in the target sample. This study aims to address this important methodological issue.MethodsThis study proposed a new method to construct PRS by (1) approximating the polygenic model using a few principal components selected based on eigen-correlation in the discovery data; and (2) conducting principal component projection on the target data. Secondary data analysis was conducted on two large scale databases: the Study of Addiction: Genetics and Environment (SAGE; discovery data) and the National Longitudinal Study of Adolescent to Adult Health (Add Health; target data) to compare performance of the conventional and proposed methods.Result and conclusionThe results show that the proposed method has higher prediction power and can handle participants from different ancestry backgrounds. We also provide practical recommendations for setting the linkage disequilibrium (LD) andpvalue thresholds.
Video-telehealth to support clinical assessment and management of acutely unwell older people in Residential Aged Care: a pre-post intervention study
Authors: Hullick Carolyn , Conway Jane , Hall Alix , Murdoch Wendy , Cole Janean , Hewitt Jacqueline , Oldmeadow Christopher , Attia John 
Published: January 2022

Abstract
Background
Older people living in Residential Aged Care (RAC) are at high risk of clinical deterioration. Telehealth has the potential to provide timely, patient-centred care where transfer to hospital can be a burden and avoided. The extent to which video telehealth is superior to other forms of telecommunication and its impact on management of acutely unwell residents in aged care facilities has not been explored previously.

Methods
In this study, video-telehealth consultation was added to an existing program, the Aged Care Emergency (ACE) program, aiming at further reducing Emergency Department (ED) visits and hospital admissions. This controlled pre-post study introduced video-telehealth consultation as an additional component to the ACE program for acutely unwell residents in RACs. Usual practice is for RACs and ACE to liaise via telephone. During the study, when the intervention RACs called the ED advanced practice nurse, video-telehealth supported clinical assessment and management. Five intervention RACs were compared with eight control RACs, all of whom refer to one community hospital in regional New South Wales, Australia. Fourteen months pre-video-telehealth was compared with 14 months post-video-telehealth using generalized linear mixed models for hospital admissions after an ED visit and ED visits. One thousand two hundred seventy-one ED visits occurred over the 28-month study period with 739 subsequent hospital admissions.

Results
There were no significant differences in hospital admission or ED visits after the introduction of video-telehealth; adjusted incident rate ratios (IRR) were 0.98 (confidence interval (CI) 0.55 to 1.77) and 0.89 (95% CI 0.53 to 1.47) respectively.

Conclusions
Video-telehealth did not show any incremental benefit when added to a structured hospital avoidance program with nursing telephone support.

Trial registration
The larger Aged Care Emergency evaluation is registered with ANZ Clinical Trials Registry, ACTRN12616000588493.