bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disseminating the IKT Guiding Principles: What did we do? Where did we go? What do we do and where do we go next?
Authors: Shwed Alanna , Hoekstra Femke , Bhati DivyaKanwar , Athanasopoulos Peter , Chernesky John , Ginis Kathleen Martin , McBride Christopher , Mortenson W.Ben , Sibley Kathryn , Sweet Shane , Panel SCI Guiding Principles Consensus , Gainforth Heather 
Published: October 2022

Abstract
Introduction

Knowledge mobilization, specifically dissemination, and research partnerships are helpful for ensuring research is translated to practice. However, empirical data reporting on the processes and outcomes of a partnership approach to dissemination are limited. Sharing and promoting the Integrated Knowledge Translation (IKT) Guiding Principles for conducting and disseminating spinal cord injury research in partnership provide an ideal opportunity to demonstrate the processes and outcomes of a partnership approach to dissemination.

Methods

The dissemination process of the IKT Guiding Principles included four iterative phases: 1) planning dissemination, 2) conducting dissemination; 3) evaluating dissemination, and 4) reflecting on dissemination. Dissemination activities and outcomes were tracked using 5 sources: a partnership tracking survey, a partnership curriculum vitae, Google Analytics, team emails, and a citation-forward search. Important outcomes tracked were exposure, engagement, and citations. Exposure and engagement to the IKT Guiding Principles were defined as the number of times and/or locations the IKT Guiding Principles were accessed and/or downloaded.

Results

The IKT Guiding Principles Partnership planned dissemination of the guiding principles from the beginning of the project. Dissemination activities formally commenced with a variety of approaches including direct emails, social media posts, a webinar, academic and community presentations, journal publications. Within the first 20 months of publication, the guiding principles were viewed 3058 times, accessed in 31 different countries (exposure), downloaded 282 times (engagement), and cited 30 times.

Conclusion

This project provides an overview of metrics and methodology that can be used to monitor and evaluate the processes and outcomes of an IKT approach to dissemination. Overall, a co-production approach may be helpful for disseminating research findings; however, more research is needed to understand the impact of an IKT approach on the dissemination and implementation of research findings.
Design and Applications of Mesoporous Silica Nanoparticle loaded Copper as a Colorimetric Sensor for glutathione detection
Authors: aghayan morvarid , mahmoudi ali , sazegar Mohammadreza , Jahanafarin Alireza , Nazari Omid , Hamidi Parisa , Poorhasan Zeynab , Shafaei Batul Sadat 
Published: October 2022

AbstractIn recent years, the development of nanomaterials-based peroxidase mimics as enzyme sensors have been attracting considerable interest due to their outstanding features, including potent stability and cost-effectiveness toward natural enzymes. In this work, mesoporous silica nanoparticles-functionalized by copper (Cu-MSN) was prepared as a new artificial enzyme for the first time through the sol-gel procedure. A comprehensive investigation of the catalytic activity of Cu-MSN was done through the oxidation of chromogenic peroxidase substrates,3,3′,5,5′- tetramethylbenzidine (TMB) and (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), in the presence of H2O2. The results indicate that the peroxidase-like activity of the as-prepared sample is significantly higher than other nanoparticles. Additionally, for the study, a facile and rapid sensing method based on the enzyme-like activity of Cu-MSN to detect H2O2and glutathione (GSH) was developed to examine the potency of the proposed biosensor. Preliminary analysis revealed that the limit of detection (LOD) of H2O2and GSH is 0.2 and 0.0126 μM, in the range of 0.9-100 and 0.042-1 μM, respectively. These findings support the claims for the efficiency of the sensor in detection fields. Also, human serum was utilized as the real sample to obtain additional evidence.
WITHDRAWN: Association between the reduced expression of RECK and neutrophilic inflammation in chronic obstructive pulmonary disease
Authors: Fang Xuejie , Li Shuangbao , Liu Hong , Han Wei , Li Yongchun , Yu Xinjuan , Li Qinghai 
Published: October 2022

Abstract
Objective
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a new inhibitor of matrix metalloproteinase (MMP), plays a vital role in tumor invasion. Patients with chronic obstructive pulmonary disease (COPD) are at higher risk of developing lung cancer, however, the role of RECK on COPD has not been studied. This study explored the expression of RECK in COPD patients and its effect on neutrophil function to provide a new scientific basis for the prevention and treatment of COPD.
Method
Fifty patients with acute exacerbation of COPD and fifty healthy controls were enrolled in the study. RECK was detected in lung tissue, sputum and plasma of subjects as well as in BEAS-2B cells stimulated with cigarette smoke extract (CSE) by immunohistochemistry, ELISA and qRT-PCR. Meanwhile, lung function (FEV1%pred) and inflammatory cytokines (IL-6 and IL-8) were examined, and correlation analysis was performed with RECK expression. The effect of RECK on proliferation, apoptosis, migration and inflammatory cytokines and its potential mechanism were further quantified by neutrophil stimulated with recombinant human RECK protein (rhRECK) combined with CSE using CCK8, flow cytometry, Transwell assay, qRT-PCR, ELISA and Western blot.
Results
RECK was mainly expressed on airway epithelial cells in normal lung tissue and was significantly diminished in COPD patients. The levels of RECK in sputum and plasma were also significantly decreased in COPD patients. Pearson correlation analysis showed that RECK level in plasma was positively correlated with FEV1%pred (r = 0.458, P < 0.001) and negatively correlated with IL-6 and IL-8 (r=-0.386, -0.437; P = 0.006, 0.002) in COPD patients. The expression of RECK was decreased in BEAS-2B stimulated with CSE. The migration, inflammation, and MMP-9 expression of neutrophils were promoted by CSE, while inhibited by rhRECK.
Conclusions
RECK is low expressed in COPD patients and negatively correlated with inflammation. It may inhibit the inflammation and migration of neutrophils by downregulating MMP-9.
Detection and location of HBV in hepatitis B surface antigen seropositive donors’ corneas
Authors: Li Gaoyang , Liu Hanhan , Hu Shuyu , Lei Xiang , Tan Jia , Deng Zhihong 
Published: October 2022

Abstract
Introduction To investigate the presence and distribution of hepatitis B virus (HBV) in the corneas of hepatitis B virus surface antigen (HBsAg) seropositive donors in different preservation media and times.
Materials and Methods Eight corneas were acquired from seven HBsAg seropositive donors. Four corneas were preserved in storage media for less than two weeks (group A), two corneas were put in glycerin for a month (group B), and two corneas were put in glycerin for a year (group C). Two corneas were acquired from two HBsAg seronegative donors and set as a control group. One was put into bottles with storage media for a week. Another was kept in glycerin for a year.
Results Immunofluorescent staining was used to identify and localize HBsAg. With immunofluorescence staining, HBV surface antigens were observed in the epithelium and/or endothelium layer in three out of eight corneas of HBsAg seropositive donors.
Conclusion The results show that HBsAg can be detected in the epithelium and/orendothelium layer of the cornea in HBsAg seropositive donors, regardless of preservation media or duration.
Mathematical modeling on a novel manufacturing method for roller-gear cams using a whirl-machining process
Authors: Andrianto Moeso , Wu Yu-Ren , Arifin Achmad 
Published: October 2022

Abstract
The whirl-machining process is a precise, efficient, and promising machine process for manufacturing workpieces over the milling process. At the same time, the roller-gear cam has advantages over the other cam-follower system. However, the whirl-machining process has not been applied to manufacture the roller-gear cam. Therefore, this paper proposes a novel method for roller-gear cam manufacturing using a whirl-machining process. Mathematical modeling is described for generating the roller-gear cam, roller, and whirl-milling tool surface. A novel CNC machine and its coordinate system are proposed. Cutting simulations for obtaining the surface topologies and normal deviations are conducted. Globoidal cam with different cylindrical rollers, globoidal cam with a conical roller, and cylindrical cam with a conical roller are taken as case studies, and results are discussed. A virtual cutting simulation was conducted using VERICUT. Some machining examples are shown to verify the benefits of the proposed method in roller-gear cam manufacturing.
Comparison of testosterone and cortisol response to violent images, and mental health, between urban and suburban citizens in a middle-income country
Authors: Cerda-Molina Ana Lilia , Mayagoitia-Novales Lilian , Mendoza-Mojica Sheila Adriana , Borráz-León Javier I. , Hernández-Melesio Alejandra M.P. , Saldívar-Hernández Gabriela Josefina 
Published: October 2022

Abstract
Purpose: To evaluate alterations in cortisol and testosterone response after the exposure to images with traumatic or violent content, as well as their association with mental health indicators, by comparing an urban and a suburban population in a middle-income country.
Methods: We quantified cortisol and testosterone response in a sample of 122 voluntaries from the State of Mexico, and from Mexico City, using saliva samples collected at 0, 15, 30, and 60 min after the exposure of images with violent content. Participants answered a general information questionnaire and the Symptom Checklist-90-R to assess their mental health status. Generalized Estimating Equation Models were built to analyze cortisol and testosterone levels and MANOVAs were performed to test differences in participants’ mental health between cities.
Results: We found higher basal cortisol levels and a flat cortisol response in the suburban population compared to the urban one, who had lower basal levels and a peak 15 minutes after the images exposure. Testosterone levels in men decreased at 30 min, but basal levels were higher in urban men. Testosterone levels decreased 30 min after images exposure only in suburban women. Participants living in suburban areas had higher scores of somatization, obsessive-compulsive and interpersonal sensitivity, as well as more sleep disorders than participants living in urban areas.
Conclusion: This study offers novel evidence about differences in cortisol and testosterone responses to a socially evaluative stressor and in mental health indicators between urban and suburban citizens, highlighting the impact of urbanization process on physiological and psychological outcomes.
Flushing of the Follicules in Ovum Pick-Up Procedures Gives a Better Chance for Pregnancy in Low Ovarian Reserve Patients
Authors: ORAL SERKAN , ŞİŞMANOĞLU ALPER 
Published: October 2022

Abstract
Background
This study aims compare the pregnancy and live birth rates between the oocytes retrieved without follicular flushing FF(-) in the oocyte pick-up (OPU) procedure performed in women with diminished ovarian reserve (DOR) and those retrieved by follicular flushing FF(+).
Results
The study was conducted among patients diagnosed with DOR according to Bologna criteria and applied to the clinic for IVF between 2017–2020. A total of 358 infertile women with follicles three and below on the hCG day, between the ages of 21 and 42, without severe male factor, without uterine anomaly, without uterine surgery, and who did not undergo PGD were included in the study. Each follicle was aspirated once in the OPU procedure, and if a follicle was retrieved, it was moved to the other follicle. If the follicle could not be retrieved, the oocyte was tried to be retrieved by flushing a maximum of 3 times. The number of oocytes retrieved, clinical pregnancy rate, and live birth rate were compared. Since all the oocytes retrieved in 143 patients were retrieved directly without the need for FF, it was named FF(-) group. Since at least one oocyte of the remaining 215 patients was retrieved by performing FF, it was named FF(+) group. Since some of the oocytes retrieved from 112 patients in the FF(+) group were retrieved with FF and some without FF, they were excluded from the study, and the remaining 103 cases formed the FF(+) group a total of 246 patients were compared. The mean number of MII oocytes ,the pregnancy rates, rates of live births and the abortion rates between two groups did not show any statistical difference.
Conclusion
FF applied during oocyte retrieval in DOR did not positively affect the number of retrieved oocytes, clinical pregnancy, and live birth rates even doing this may decrease the pregnancy rate because of the probable low quality egg but we should not forget that if we did not do flushing after once we aspirated the follicle we would not be able to obtain any pregnancy at all in this patients.
Comparative prognostic value of different definitions of prediabetes in patients with angiographic coronary intermediate lesions: a prospective cohort study
Authors: Song Chenxi , Yuan Sheng , Cui Kongyong , Cai Zhongxing , Zhang Rui , He Jining , Qiao Zheng , Bian Xiaohui , Wu Shaoyu , Wang Haoyu , Shi Boqun , Lin Zhangyu , Fu Rui , Wang Chunyue , Liu Qianqian , Jia Lei , Dou Kefei 
Published: October 2022

Abstract
Background
Prediabetes is common and associated with poor prognosis in patients with acute coronary syndrome and those undergoing revascularization. However, the impact of prediabetes on prognosis in patients with coronary intermediate lesions remains unclear. The objective of the current study is to explore the impact of prediabetes and compare the prognostic value of the different definitions of prediabetes in patients with coronary intermediate lesions.
Methods
A total of 1532 patients with intermediate coronary lesions on coronary angiography and not undergoing revascularization were enrolled in the current study. Patients were classified as normal glucose tolerance (NGT), prediabetes and diabetes according to various definitions based on HbA1c or admission fasting glucose. The primary endpoint was defined as major adverse cardiovascular events (MACE), the composite endpoint of all-cause death, non-fatal myocardial infarction and repeated revascularization therapy. Multivariate cox regression model was used to explore the association between categories of abnormal glucose category and MACE risk.
Results
The proportion of patients defined as prediabetes ranged from 3.92–47.06% depending on the definition used. A total of 197 MACE occurred during a median follow-up time of 6.1 years. Multivariate cox analysis showed that prediabetes according to the International Expert Committee (IEC) guideline (6.0 ≤ HbA1c < 6.5%) was associated with increased risk of MACE compared with NGT (hazard ratio[HR]: 1.705, 95% confidence interval [CI]: 1.143–2.543) and after confounding adjustment (HR: 1.513, 95%CI: 1.005–2.277). Consistently, the best cut-off point of glycated haemoglobin (HbA1c) identified based on the Youden’s index was also 6%. Restricted cubic spline analysis delineated a linear positive relationship between baseline HbA1c and MACE risk.
Conclusions
In this cohort of patients with intermediate coronary lesions not undergoing revascularization therapy, prediabetes based on the IEC-HbA1c definition was associated with increased MACE risk compared with NGT, and may assist in identifying high-risk patients who can benefit from early lifestyle intervention.
Effects of Dl-3-n-butylphthalide on Cognitive Functions and Blood-brain Barrier in Chronic Cerebral Hypoperfusion Rats
Authors: Ma Yang , Chen Shiling , Li Yuanwei , Wang Jiahui , Yang Jingfei , Jing Jie , Liu Xia , Li Yunjie , Wang Jingyi , Zhang Ping , Tang Zhouping 
Published: October 2022

Abstract
Vascular cognitive impairment (VCI) have been one of the main type of cognitive impairment. Chronic cerebral hypoperfusion (CCH) is the main cause of VCI. Blood-brain barrier damage plays an essential part in the pathogenesis of CCH induced cognitive impairment. At present, the treatment to VCI mainly focused on prevention, there is no drug clinically approved for the treatment of VCI. This study investigated the effects of DL-3-n-butylphthalide (NBP) on cognitive function and blood-brain barrier in chronic cerebral hypoperfusion rats. A modified bilateral common carotid artery occlusion (mBCCAO) model was applied to imitate chronic cerebral hypoperfusion. The feasibility of the model was verified by laser Doppler, 13N-Ammonia-Positron Emission Computed Tomography (PET) and Morris Water Maze. Subsequently, Morris water maze experiment to evaluate the effect of different doses of NBP (40mg/kg, 80mg/kg) on the improvement of cognitive impairment induced by mBCCAO. Evans blue staining and western blot of tight junction protein were conducted to explore the effect of NBP on the blood-brain barrier protection. At the same time, the changes of pericyte coverage in mBCCAO model and the effect of NBP on pericyte coverage were preliminarily explored. We found that, mBCCAO surgery led to obvious cognitive impairment and decreased whole cerebral blood flow in rats, among which the blood flow in cortex, hippocampus and thalamus brain regions decreased more significantly. High-dose NBP (80 mg/kg) improved long-term cognitive function in mBCCAO rats, alleviates Evans blue leakage and reduces the loss of tight junction proteins (ZO-1, Claudin-5) in the early course of the disease, thereby exerting a protective effect on the blood-brain barrier. No significant changes in pericyte coverage were observed after mBCCAO.
Production of a biopolymer for leather. A life cycle assessment perspective
Authors: Ballús Olga , Guix Meritxell , Micó Ricardo , Bacardit Anna 
Published: October 2022

Abstract
The aim of this paper was to develop a biopolymer based on raw materials not originating from petroleum chemistry to reduce the environmental impact. To this end, an acrylic-based retanning product was designed where part of the fossil-based raw materials was replaced with biomass-derived polysaccharides. Life cycle assessment (LCA) of both the new biopolymer and a standard product was conducted to determine the environmental impact caused by each product. The biodegradability of both products was determined by BOD5/COD ratio measurement. Both products were characterized by IR, gel permeation chromatography (GPC), and Carbon-14 content. The new product was experimented as compared to standard fossil-based product, and the main properties of leathers and effluents were assessed. The results showed that fossil-based raw materials can be partially replaced with biomass derivatives while providing the leather with similar organoleptic characteristics. The new biopolymer showed higher biodegradability and better exhaustion (lower COD). LCA allowed concluding that the new biopolymer reduces the environmental impact of 4 of the 19 impact categories analyzed; in particular, the carbon footprint was reduced by 9% vs. the standard acrylic resin. Finally, a sensitivity analysis was performed where the polysaccharide derivative was replaced with a protein derivative. The analysis concluded that the protein-based biopolymer clearly reduced the environmental impact in 16 of the 19 categories studied. In this case, the carbon footprint was reduced by 47%. Therefore, the choice of the biopolymer is critical in this type of products, which may or may not reduce the environmental impact.
Design of Multistage Class-AB/J Power Amplifier for 5G Smart grid’s Advanced Metering Infrastructure Applications
Authors: Nagisetty Sridhar , Chinnaiyan Senthilpari , R Mardeni , Yong Wong Hin , T Nandha Kumar 
Published: October 2022

Abstract
The wireless communication networks for Advanced Metering Infrastructure (AMI) / smart metering applications of a smart grid are in need of emerging 5G technology for providing a significant enhancement in bandwidth (BW) to support a large amount of data transmission between the Meter data management system (MDMS) of operation centre and smart meters efficiently. The entire wireless communication network’s BW and efficiency mainly depend on its Power Amplifier (PA). The design of PA that can provide high efficiency with linearity over a wide BW is essential to meet the 5G wireless communication network requirements of AMI / smart metering applications. This paper presents the design methodology of a two-stage PA that operates at a 3.5 GHz centre frequency by utilizing the CGH40010F model GaN transistor. This PA employs a Class-J mode for the power stage that will be driven by a Class-AB mode to achieve high efficiency with improved power gain over desired BW. The matching Networks(M.Ns) of the proposed two-stage PA are designed with the idea to replace its passive lumped inductors with active inductors, based on the desired optimum impedance values obtained from the load-pull techniques utilizing the ADS EDA tool. The proposed two-stage PA delivers a power output of 41dBm with 21 dB of power gain over a BW around 400 MHz, a maximum Power Added Efficiency (PAE ) of 53% and maximum drain efficiency (D.E) of 54% with a small signal gain of 27dB at 3.5GHz using 28V power supply into 50 Ω load.
Problems in Observation and Identification of Torsional Waves in the Lower Solar Atmosphere
Authors: Chelpanov Andrei , Kobanov Nikolai 
Published: October 2022

Abstract
Registering periodic variations of spectral line widths serves as the main method for observing torsional Alfvén waves. Theoretically, the method seems valid, yet it entails a number of caveats when applied to data. For instance, the amplitudes of these observations should vary with changes of the location on the disk, and they should be associated with no intensity oscillations. We analyze extensive observational material of periodic non-thermal variations of line widths in coronal holes and facular regions in a number of spectral lines: Hα, He I 10830 Å, Ca II 8542 Å, Ba II 4554 Å. In most cases, we detected affiliated intensity oscillations at similar frequencies. Besides, we observed no centre-to-limb dependency. This calls for a discussion on the practical validity of the method and on the alternative explanations for the nature of non-thermal variations of spectral line widths. Based on our observations, we consider registering line profile broadening necessary but not sufficient means for unambiguous identification of torsional Alfvén waves in the lower solar atmosphere.