bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rediscovery of the Galapagos endemic Lecocarpus leptolobus (Asteraceae), its morphology, distribution and taxonomy relative to its congeners
Authors: Tye Alan , Jaramillo Díaz Patricia 
Published: April 2022

Abstract
We report the rediscovery of Lecocarpus leptolobus at its type locality, and restrict the latter to El Ripioso, San Cristóbal, Galapagos. We compare the morphology of the population at this site with other populations of Lecocarpus on San Cristóbal and other Galapagos islands. We conclude that L. leptolobus is a valid taxon endemic to the south-western half of San Cristóbal and is not synonymous with L. lecocarpoides, whereas populations further north-east on the same island constitute a separate species validly named L. darwinii. These two taxa support the idea of a former biogeographic barrier between the two halves of San Cristóbal. Plants at two of the easternmost localities of the south-western species show some characters intermediate between the two species, possibly representing introgression following easing of the barrier. The three specimens of Lecocarpus collected on San Cristóbal by Charles Darwin, all mounted on a single herbarium sheet, comprise one branch of L. leptolobus and two of L. darwinii. We identify possible sites for Darwin’s collections based on information about his explorations. We find grounds for accepting the taxon Acanthospermum brachyceratum as a subspecies of L. lecocarpoides endemic to Gardner-by-Española, Osborn and Xarifa islets, the first of these being the type locality, demonstrating that even narrow sea barriers can contribute to plant radiation in oceanic archipelagos. On the basis of our findings, we provide a new key to the taxa of Lecocarpus.
LUtarjet-limit unique coracoid osteotomy Latarjet (With video)
Authors: Deng Zhenhan , Long Zeling , Lu Wei 
Published: April 2022

Abstract

Background
The Latarjet procedure is an effective technique for the treatment of recurrent anterior shoulder dislocation with glenoid bone loss. However, the inevitable destruction of the coracoacromial arch may result in humeral head translation. The aim of the study is to introduce a modified Latarjet technique with coracoacromial arch preservation as well as its short term clinical outcomes.

Methods
We propose a novel individualized flexible arthroscopic suture button fixation Latarjet technique called `LUtarjet' with video. Precise measurements of the coracoid process, glenoid deficiency and osteotomy plane were made preoperatively. Only three arthroscopic portals were needed and limit unique coracoid osteotomy was performed with coracoacromial arch preservation. The mini window splitting of the subscapularis was performed from the posterior to the anterior direction and the split window was as small as 8–10 mm in length.

Results
A total of 27 patients (25.6 ± 5.4 years) were included in the study. The average surgical duration was 55.6 ± 6.3 min and the mean follow-up time was 8.1 ± 1.5 months. The functional score was significantly improved at the last follow-up. Radiologic evidence showed that the bone graft healing was placed in the desired position. No complications were found.

Conclusions
We present a fast, easy, accurate, safe arthroscopic ‘LUtarjet’ technique called FEAST that can simplify the arthroscopic Latarjet process and achieve a satisfactory bone graft position and satisfactory short-term clinical outcomes.

Level of evidence
IV, case series.
Extractive Humanitarianism: Participatory Confinement and Unpaid Labor in Refugees Governmentality
Authors: Tazzioli Martina 
Published: April 2022

Abstract
This article advances the notion of “extractive humanitarianism” to designate the role played by data extraction and knowledge extraction operations in refugee governmentality. It argues that extractive operations rely on refugees’ active participation to their own governmentality—what I define as participatory confinement. The piece engages with feminist literature on unpaid labor and shows that participatory confinement implies that refugees perform unpaid labor activities, which are disguised as voluntary work. It moves on by conceptualizing participatory confinement through the lens of the invitation to governmentality. In order to develop this, the article focuses on two modes of participatory confinement: unpaid labor that asylum seekers do as “voluntary” activities and knowledge and data extraction. It concludes by questioning extractive humanitarianism in light of the subtle coercion and invisible exploitation that asylum seekers are exposed to.
Rapid invisible frequency tagging (RIFT): a promising technique to study neural and cognitive processing using naturalistic paradigms
Authors: Seijdel Noor , Marshall Tom R , Drijvers Linda 
Published: April 2022

AbstractFrequency tagging has been successfully used to investigate selective stimulus processing in electroencephalography (EEG) or magnetoencephalography (MEG) studies. Recently, new projectors have been developed that allow for frequency tagging at higher frequencies (&gt;60 Hz). This technique, rapid invisible frequency tagging (RIFT), provides two crucial advantages over low-frequency tagging as (i) it leaves low-frequency oscillations unperturbed, and thus open for investigation, and ii) it can render the tagging invisible, resulting in more naturalistic paradigms and a lack of participant awareness. The development of this technique has far-reaching implications as oscillations involved in cognitive processes can be investigated, and potentially manipulated, in a more naturalistic manner.
Simultaneous Estimation of Telmisartan, Chlorthalidone, Amlodipine Besylate and Atorvastatin by RP-HPLC Method for Synchronous Assay of Multiple FDC Products Using Analytical FMCEA-Based AQbD Approach
Authors: Prajapati Pintu , Patel Ankita , Shah Shailesh 
Published: April 2022

Abstract
Numerous reversed-phase high-pressure liquid chromatography (RP-HPLC) and high-performance thin-layer chromatography (HPTLC) techniques have been published for the estimation of fixed-dose combinations (FDCs) of telmisartan (TEL). No published literature has been reported to date which described the synchronous estimation of FDCs of TEL using a single chromatography condition. Hence, the RP-HPLC method has been developed and validated for synchronous analysis of FDCs of TEL using an enhanced analytical quality by design (AQbD) approach to save time, cost and solvent for analysis. The implementation of AQbD was initiated with the identification of failure modes (FMs) using the Ishikawa diagram, and their critical effect analysis was carried out by risk priority number ranking and filtering method. The identified critical FMs were optimized by design of experiments-based response surface modeling using the Box–Behnken design. The method operable design region was navigated and control strategy was framed to mitigate the risk of critical FM. The RP-HPLC method was developed using Shim-Pack octadecyl silane C18 column and acetonitrile: 1.0%v/v triethylamine (pH 6.5 adjusted using perchloric acid; 42:58, %v/v). The developed method was found to be validated as per the International Council For Harmonization Q2 (R1) guideline. The method was applied for the synchronous assay of seven different FDCs of TEL and assay results were found in good compliance with the respective labeled claim.
Synthesis of Molecularly Imprinted Polymers Based on a New Monomer “2-(4-Vinylphenyl) Quinoline-4-Carboxylic Acid” for the Selective Solid-Phase Extraction of Lamotrigine
Authors: Yin Deng-Yang , Lyu Nan , Qian Zeng-Ting , Zhao Lin-Lin , Wang Liang , Tang Dao-Quan , Du Yan 
Published: April 2022

Abstract
A new molecularly imprinted polymers (MIPs) have been prepared for the high selective extraction of lamotrigine (LTG), a widely used antiepileptic drug, in human serum. The MIPs were polymerized by bulk polymerization using our synthesized compound, 2-(4-vinylphenyl) quinolin-4-carboxylic acid, as functional monomer, which achieved better adsorption specificity than universal MIPs. Then, the molecularly imprinted solid phase extraction (MISPE) based on this material was coupled with high-performance liquid chromatography (HPLC) for the detection of LTG in human serum. The results of method validation showed that the developed method presented a good precision and accuracy, and the linearity was in the range of 1.50–40.00 mg/mL with the limit of quantitation (LOQ) at 0.20 mg/mL. The recovery ranged from 80.8% to 83.8% with RSD ranges from 5.5% to 11.1%. The validated method was successfully used to determine the concentration of LTG in human simulate serum samples.
Coronavirus Disease 2019 Vaccine Trials (and Tribulations): How to Improve the Process of Clinical Trials in a Pandemic
Authors: Sherman Amy C , Rouphael Nadine , Baden Lindsey R 
Published: April 2022

Abstract
Vaccine clinical trials have been essential to developing effective severe acute respiratory syndrome coronavirus 2 vaccines. The challenges of supply chain disruptions, infection control, study designs, and participant factors that affect trial procedures are reviewed, with specific solutions to streamline the clinical trial process.
From globalising to regionalising to reshoring value chains? The case of Japan’s semiconductor industry
Authors: Kamakura Natsuki 
Published: April 2022

AbstractThis study evaluates the current situation and challenges of reshoring in the Japanese manufacturing industry, focusing on the semiconductor industry, which once dominated the world. After a recent document analysis and qualitative interviews with firms’ representatives and policymakers, it is apparent that the globalised semiconductor industry is unlikely to reshore to Japan even amid supply chain disruptions due to the coronavirus disease 2019 pandemic. A review of Japan’s semiconductor-related industries, such as semiconductor manufacturing materials, validated that they are embedded in Asian production networks and need to be optimised within a regionalised production system.
Regionalisation or domesticalisation? Configurations of China’s emerging domestic market-driven industrial robot production networks
Authors: Fu Tianlan , Cheng Yeqing 
Published: April 2022

Abstract
From global production network (GPN) theory, this study explores the configurations of emerging Southern market-driven production networks through the case of China’s industrial robot industry which has emerged with increasing automation in production. This paper argues that to serve the Chinese high- and middle-end customers, global lead firms from Western economies have established regional production networks by localising production, connecting with global component suppliers in/outside China and collaborating with Chinese system integrators. However, Chinese capable firms have organised domestic production networks for the low and middle-end through integrating with domestic component suppliers and system integrators. This study adapts the GPN framework, mostly highlighting Western markets, by examining markets and firms in the Global South and revealing new configurations of production networks.
Tasks, occupations and slowbalisation: on the limits of fragmentation
Authors: Brakman Steven , van Marrewijk Charles 
Published: April 2022

AbstractFollowing the trade collapse in 2009, Globalisation has recovered but the growth rate slowed down compared to the preceding period of Hyper Globalisation. The persistence of this slowdown is remarkable. We argue that increased awareness of firms for the costs of involvement in global supply chains can explain the recent developments in trade flows. We formalise the existence, length and consequences of changes in fragmentation cost along global supply chains. From a theoretical point of view, we allow tasks to be a combination of different occupations while the model endogenises production fragmentation, allowing for multiple production stages in multiple countries, while remaining tractable. From an empirical point of view, the model explains both the period of Hyper Globalisation and the subsequent Slowbalisation in terms of changing fragmentation costs along global supply chains. The model is also consistent with developments regarding labour market polarisation associated with modern globalisation: the labour market position of medium-skilled workers in advanced countries has deteriorated relative to high- and low-skilled workers, which can be understood by changing global supply chains. Our model implies, however, that even with zero fragmentation costs the demand for certain occupations does not fall to zero for any country.
Kidney–placenta crosstalk in health and disease
Authors: Cabarcas-Barbosa Omar , Capalbo Olivia , Ferrero-Fernández Alberta , Musso Carlos G 
Published: April 2022

ABSTRACT
Organ crosstalk allows the interaction between systems to adapt to a constant changing environment, maintaining homeostasis. The process of placentation and the new hormonal environment during pregnancy trigger physiological changes that modulate kidney function to control extracellular volume, acid–base balance and filtration of metabolic waste products. The bidirectional communication means that acute or chronic dysfunction of one organ can compromise the other. Abnormal placentation in pregnancy-related hypertensive disorders such as pre-eclampsia and HELLP (haemolysis, elevated liver enzymes and low platelet count) syndrome leads to the release of antiangiogenic factors that may cause kidney injury (thrombotic microangiopathy, glomeruloendotheliosis, mesangiolysis and vasoconstriction of peritubular vessels). These hypertensive disorders are a key cause of kidney injury in gestation, which increases maternal morbimortality and adverse foetal outcomes. Conversely, prior kidney injury or causes of kidney injury (diabetes, lupus, glomerulonephritis or other forms of chronic kidney disease) increase the risk of developing hypertensive pregnancy disorders, providing a baseline higher risk. Inherited kidney diseases are a special concern, given the potential for genetic predisposition to kidney disease in the foetus. Understanding the bidirectional potential for compromise from placenta to kidney and vice versa provides a better framework to limit damage to both organs and improve maternal and foetal outcomes.
Expert guidance on the multidisciplinary management of cystinosis in adolescent and adult patients
Authors: Levtchenko Elena , Servais Aude , Hulton Sally A , Ariceta Gema , Emma Francesco , Game David S , Lange Karin , Lapatto Risto , Liang Hong , Sberro-Soussan Rebecca , Topaloglu Rezan , Das Anibh M , Webb Nicholas J A , Wanner Christoph 
Published: April 2022

ABSTRACT
Cystinosis, a rare autosomal recessive lysosomal storage disorder, results in an abnormal accumulation of the amino acid cystine in multiple organs and tissues of the body. Renal symptoms typically develop in the first few months of life, with extra-renal manifestations becoming apparent over the next 10–20 years, which require coordinated multidisciplinary care. Here, we describe a consensus-based guidance to support the management of adolescents and adults living with cystinosis. The programme was led by a Steering Committee (SC) of six experts in the management of patients with cystinosis, who identified a list of 15 key questions reflecting the multi-organ effects of cystinosis. An Extended Faculty (EF) of eight additional specialists was invited to answer the questions via an online digital platform using a quasi-Delphi approach. The consolidated answers were summarized into recommendations. Where evidence was lacking, recommendations were developed using collective expert consensus. The EF was asked to agree/disagree with the clinical recommendations. The expert-agreed clinical recommendations provide guidance that considers both renal and extra-renal systems. The topics covered are advice on fertility and family planning, consideration of the nervous, muscular, ophthalmic, cardio-respiratory, endocrine, dermatological and gastrointestinal systems, as well as guidance on dental care, diet, lifestyle, and improving quality of life and psychological well-being. In summary, this work outlines recommendations and a checklist for clinicians with a vision for improving and standardizing the multidisciplinary care for patients with cystinosis.
Learning Disjunctive Multiplicity Expressions and Disjunctive Generalize Multiplicity Expressions From Both Positive and Negative Examples
Authors: Li Yeting , Chen Haiming , Chen Zixuan 
Published: April 2022

Abstract
The presence of a schema for eXtensible Markup Language (XML) documents has numerous advantages. Unfortunately, many XML documents in practice are not accompanied by a (valid) schema. Therefore, it is essential to devise algorithms to infer schemas from XML documents, where the fundamental task is learning regular expressions. In this paper, we focus on the learning of disjunctive multiplicity expressions (DMEs), a subclass of regular expressions that are particularly suitable to specify unordered models and have been used as the foundation of the schemas for unordered XML. Previous work for learning DME lacks inference algorithms that support positive and negative examples. Further, presently there has been no algorithm can learn DMEs extended with numeric occurrences. We address these challenges in the present paper and first propose a novel algorithm to learn DMEs from positive and negative examples by using genetic algorithms and parallel techniques. Then we extend DMEs to disjunctive generalized multiplicity expressions (DGMEs), which allow numeric occurrences and develop an algorithm to learn DGMEs from positive and negative examples. Finally, experimental results show that with only positive examples, our algorithm can generate a DME with an acceptable learning time, which can accept all positive examples, and when given both positive and negative examples, we can learn DMEs or DGMEs with high accuracy.
Hamiltonian Properties of the Data Center Network HSDC with Faulty Elements
Authors: Dong Hui , Fan Jianxi , Cheng Baolei , Wang Yan , Xu Li 
Published: April 2022

Abstract
The data center network HSDC is a superior candidate for building large-scale data centers, and strikes a good balance among diameter, bisection width, incremental scalability and other important characteristics in contrast to the state-of-the-art data center network architectures. The Hamiltonian property is an important indicator to measure the reliability of a network. In this paper, we study the Hamiltonian properties of HSDC’s logic graph $H_n$. Firstly, we prove that $H_n$ is Hamiltonian-connected for $n\geq 3$. Secondly, we propose an $O(NlogN)$ algorithm for finding a Hamiltonian path between any two distinct nodes in $H_n$, where $N$ is the number of nodes in $H_n$. Furthermore, we consider the Hamiltonian properties of $H_n$ with faulty elements, and prove that $H_n$ is $(n-3)$-fault-tolerant Hamiltonian-connected and $(n-2)$-fault-tolerant Hamiltonian for $n\geq 3$.
The Homeric Διὸς ἀπάτη and its reuse within the seventeenth-century Portuguese epic poemUlisseia ou Lisboa Edificada
Authors: Fonseca Rui Carlos 
Published: April 2022

AbstractUlisseia ou Lisboa Edificada (Ulysseia or Lisbon Founded) is a seventeenth-century epic poem written by Gabriel Pereira de Castro, which celebrates the mythical arrival of Ulysses in Lusitania and the subsequent foundation of Ulisseia by him. This city built by Greek hands comes to be Lisbon, the head of a great navy empire at the time of Portuguese Discoveries. This epic reshapes both the Odyssean sea voyages and Iliadic warfare, whereas Ulysses, the same crafty wanderer as the Homeric Odysseus, is also the bearer of a god-given mission like the Virgilian Aeneas. In this article, I examine the refashioning of the Homeric Διὸς ἀπάτη (‘Deception of Zeus’) in Ulisseia book 10 from a comparative and literary perspective. Castro follows his Greek model very closely, but at the same time it departs from it in important ways. In portraying the deceitful planning of Hera, with its erotic and humorous tone, he adapts it to the nationalistic purposes of his own epic story. Juno’s plan is granted a more serious tone, since its effects on the war between Greeks and Lusitanians are directly linked to the glorious Destiny of the Portuguese people.
Clinging to Flesh: Embodied Experience in Contemporary Women’s Dystopias
Authors: Schneider Ana-Karina 
Published: April 2022

Abstract
In much contemporary speculative fiction by women, the cyborgization of the body is metaphoric rather than physical, suggesting ambivalence toward artificial enhancements and reproduction. Drawing on the recent material turn in feminism, this essay analyzes representations of the agency of matter and the interdependencies of nature and culture that shape women’s experiences and thus help envision alternative futures. Rather than replicate patriarchal and rationalist representational patterns, the figure of the childbearing woman in novels from Margaret Atwood’s The Handmaid’s Tale to Louise Erdrich’s Future Home of the Living God thematizes both the inescapability of corporeality and the subtle forms of exploitation, whose persistence is inscribed on the pregnant female, racialized, or even cyborgized body. Its foregrounding, I argue, is a form of ethical activism.
PCRMS: a database of predicted cis-regulatory modules and constituent transcription factor binding sites in genomes
Authors: Ni Pengyu , Su Zhengchang 
Published: April 2022

Abstract
More accurate and more complete predictions of cis-regulatory modules (CRMs) and constituent transcription factor (TF) binding sites (TFBSs) in genomes can facilitate characterizing functions of regulatory sequences. Here, we developed a database predicted cis-regulatory modules (PCRMS) (https://cci-bioinfo.uncc.edu) that stores highly accurate and unprecedentedly complete maps of predicted CRMs and TFBSs in the human and mouse genomes. The web interface allows the user to browse CRMs and TFBSs in an organism, find the closest CRMs to a gene, search CRMs around a gene and find all TFBSs of a TF. PCRMS can be a useful resource for the research community to characterize regulatory genomes.
Database URL: https://cci-bioinfo.uncc.edu/
Phenology, Density and Parasitism of Asian Chestnut Gall Wasp (Dryocosmus kuriphilus) (Hymenoptera: Cynipidae) in Recently Invaded Chestnut (Castanea spp.) Orchards in Michigan
Authors: Labbate Louise , McCullough Deborah G 
Published: April 2022

Abstract
Asian chestnut gall wasp (ACGW) (Dryocosmus kuriphilus Yasumatsu), an invasive pest native to China, was detected in Michigan, the largest chestnut producer in North America, in 2015. Along with quantifying gall densities, we tracked dates and cumulative growing degree days corresponding to ACGW life stages in five, seven, and nine orchards in 2017–2019, respectively. Gall formation, triggered by the onset of feeding by overwintered larvae, began soon after bud break. Most adult wasps emerged in mid summer, after pollen production peaked. Density of ACGW in all sites dropped sharply in 2019, probably as a result of larval mortality caused by severely cold temperatures in late January. Gall density was generally lower on Chinese chestnut (Castanea mollisima Blume) trees and C. mollisima hybrids, which share some coevolutionary history with ACGW, than on cultivars of European chestnut (C. sativa Miller) and Japanese-European (C. crenata Sieb. & Zucc. x C. sativa) trees, including the popular Colossal cultivar. Torymus sinensis Kamijo (Hymenoptera: Torymidae), a larval parasitoid previously introduced into the U.S. and several countries in Asia and Europe for ACGW biocontrol, appears to be spreading with ACGW in Michigan. Parasitoid larvae were recorded in four, six, and eight of the infested sites we sampled in 2017–2019, respectively, and parasitism rates ranged from 5 to70% of galls.