bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyobanche hanekomii(Orobanchaceae) is pollinated by non-flying mammals and birds
Authors: Niedzwetzki-Taubert Tim 
Published: December 2022

AbstractH. hanekomiiwas recently described as a new member of the genusHyobancheinside the Orobanchaceae family.H. hanekomiiis a small geoflorous holoparasitic plant, which often grows under shrubs and has red-flowered inflorescences, which do not emit a scent. The plant combines characteristics from bird- and mammal-pollinated plants. Until now it was uncertain ifH. hanekomiiis pollinated by birds or by non-flying mammals, since the species is showing an intermediate morphology when compared toH. atropurpurea(mammal pollinated) andH. sanguinea(bird pollinated). Elephantulus edwardiiandNectarinia famosawere observed foraging onH. hanekomiiinflorescences indicating a mixed pollination syndrome or a transmission state between bird pollination to pollination by non-flying mammal. In this study I prove thatE. edwardiiandN. famosaare indeed pollinators ofH. hanekomii. This was done by observing the interaction between different animal species andH. hanekomiiinflorescences in their natural habitat by using camera traps and camcorders.It could be observed thatE. edwardiilicked nectar from flowers ofH. hanekomiiwith its long tongue. The animals pressed their rostra deep into the flowers. While foraging on the flowers, it could be observed that pollen was placed onto the rostra of the animals. It was also observed, that the stigma of the flower touched the animals on the same spots where pollen was placed. To drink on the flowers,Nectarinia famosainserted its beak into the flowers. While doing so, it was observed that pollen was placed on the beaks and that the stigma touched the animals. It is possible that both species transport pollen from oneH. hanekomiiflower to another while foraging on them, and that the pollen reaches the stigma of another flower. Because of this both species are considered as pollinators ofH. hanekomii.E. edwardiiwas identified as the main pollinator ofH. hanekomiias they visit the inflorescences frequently.N. famosawas detected as a secondary pollinator ofH. hanekomiias they visit the flowers infrequently. This issue has to be examined further since the rarity ofN. famosavisits could be influenced by different factors like removal of perching positions around the plants to have a better camera angel or by the cameras itself, so thatN. famosawould visit theH. hanekomiiinflorescences more often in an non altered surrounding.In addition UV photography and spectrometry revealed that no UV reflecting areas are present on the plants indicating adaption to non-flying mammal than bird pollination syndrome. The same counts for missing stinging hairs on the flowers. In contrary some of the important flower characteristics (Flower entrance width and height) are significant smaller than those of the non-flying mammal pollinated plantH. atropurpureaindicating a bird pollination syndrome.
Seasonality and the persistence of vector-borne pathogens
Authors: Khong Van Hai , Carmona Philippe , Gandon Sylvain 
Published: December 2022

AbstractMany vector-borne diseases are affected by the seasonality of the environment. Yet, seasonality can act on distinct steps of the life-cycle of the pathogen and it is often difficult to predict the influence of the periodic fluctuations of the environment on the persistence of vector-borne pathogens. Here we analyse a general vector-borne disease model and we account for periodic fluctuations of different components of the pathogen’s life-cycle. We develop a perturbation analysis framework to obtain useful approximations to evaluate the overall consequences of seasonality on the persistence of pathogens. This analysis reveals when seasonality is expected to increase or to decrease pathogen persistence. We show that seasonality in vector density or in the biting rate of the vector can have opposite effects on persistence and we provide a useful biological explanation for this result based on the covariance between key compartments of the epidemiological model. This framework could be readily extended to explore the influence of seasonality on other components of the life cycle of vector-borne pathogens.Significance statementDoes seasonality increase or decrease the persistence of vector-borne diseases? The devil is in the details and our analysis shows that the effect of seasonality depends on which pathogen traits are affected by seasonality. We highlight the contrasting effects of seasonality in the abundance and/or in the biting rate of the vector on pathogen persistence.
A Landscape Analysis of the Recent Rise of Healthcare Data Science Degree Programs
Authors: Bhandari Aman , Cohen Austin , Fung Maxwell , Panch Trishan , Aronov Alex , Michaud Nicholas 
Published: December 2022

ABSTRACTThere has been an explosion in formal data science and healthcare data science programs, degrees and tracks at the university level over the last five years, with over 100 universities currently offering formal data science degrees. We conducted a landscape analysis of healthcare-related data science programs in the United States to characterize these new academic degree offerings, identifying 29 healthcare focused data science programs at four-year colleges and universities in the United States. Programs were analyzed across a range of features, providing the first view into what constitutes “healthcare data science” education.
Genome-wide Association Study Meta-analysis of Neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration
Authors: Ahmad Shahzad , Imtiaz Mohammad Aslam , Mishra Aniket , Wang Ruiqi , Herrera-Rivero Marisol , Bis Joshua C , Fornage Myriam , Roshchupkin Gennady , Hofer Edith , Logue Mark , Longstreth WT , Xia Rui , Bouteloup Vincent , Mosley Thomas , Launer Lenore , Khalil Michael , Kuhle Jens , Rissman Robert A. , Chene Genevieve , Dufouil Carole , Djoussé Luc , Lyons Michael J. , Mukamal Kenneth J. , Kremen William S. , Franz Carol E. , Schmidt Reinhold , Debette Stephanie , Breteler Monique M.B. , Berger Klaus , Yang Qiong , Seshadri Sudha , Aziz N. Ahmad , Ghanbari Mohsen , Ikram M. Arfan 
Published: December 2022

AbstractBackgroundNeurofilament light chain (NfL) levels in circulation have been established as a sensitive biomarker of neuro-axonal damage across a range of neurodegenerative disorders. Elucidation of the genetic architecture of blood NfL levels and its genetic correlation with neurological traits could therefore provide new insights into shared molecular mechanisms underlying neurodegenerative disorders.MethodsTo identify the genetic variations underlying blood NfL levels, we conducted an ancestry-specific meta-analyses of genome-wide association studies (GWAS) based on 18,532 participants from 11 cohorts of European and 1142 participants (3 cohorts) of African-American ancestry. In the post-GWAS analyses, we performed expression quantitative trait loci (eQTL) analysis, LD-regression, and genetic risk score (GRS) association analysis with neurological traits.ResultsIn the European ancestry GWAS meta-analysis, we identified two genome-wide significant (P< 5x10−8) loci at 16p12 (UMOD), and 17q24 (SLC39A11). In the African-American ancestry GWAS meta-analysis, we identified three novel loci at 1q43 (FMN2), 12q14, and 12q21. Genetic correlation based on the European ancestry meta-analysis with neurological traits showed a strong genetic correlation of NfL with Alzheimer’s disease(AD) (rg= 0.32,P= 1.74x10−6), total-tau (rg= 2.01,P= 1.03x10−6), amyloid-beta (Aβ)-40 (rg= 0.80,P= 6.92x10−6), and Aβ-42 (rg= 1.03,P= 4.39x10−5). A higher genetic risk score based on NfL-associated genetic variants was also related to increased plasma levels of total-tau (P= 1.97x10−4), Aβ-40 (P= 2.24x10−5), Aβ-42 (P= 2.92x10−4) in the Rotterdam Study.ConclusionThis large-scale GWAS meta-analysis revealed multiple novel genetic loci of NFL levels in blood in participants from European and African-American ancestry. Significant genetic correlation of genes underlying NfL with AD, Aβ-42, and total-tau may indicate a common underlying pathway of neurodegeneration.
Variabilities and similarities of adult stem cells derived intestinal organoids originating from different intestinal segments in pig
Authors: Kar Soumya K. , te Pas Marinus F.W. , Rikkers Roxann , Madsen Ole , Taverne Nico , Ellen Esther D. , Wells Jerry M. , Schokker Dirkjan 
Published: December 2022

1.ABSTRACTOrganoids arein vitromodel systems generated from tissues. Organoids express specific physiological functions associated with their original tissue location and they express tissue-segment-specific genes. The aim of this study was to culture pig organoids from different areas of intestinal segments: duodenum, ileum (with or without Peyers Patches (PP)), and colon, to investigate the resemblance with thein vivotissues and variability of multiple adjacent sampling sites based on histology and transcriptome profiles. The transcriptome profiles of thein vivotissues and the derived organoids showed high resemblance for all intestinal segments. For the transcriptomic cluster analysis it was shown that it is important to use tissue important genes to shown the resemble between tissue and their derived organoids. The transcriptome profiles clearly separated the intestinal segments, and samples of the same segment from adjacent tissue locations showed high transcriptome profile similarity. Ileum samples with and without PP were also separated. Pathway analysis of differentially expressed genes from PP compared with non-PP suggested the importance of several aspects of cell cycle progression regulation, including DNA metabolism, chromatin organization, regulation of mitotic stage progression, and regulation of inflammation. Based primarily on the transcriptomics results, we conclude that organoids reflect the sampled intestinal segment and that organoids derived from adjacent sampling sites in an intestinal tissue segment showed low variability. The results from the ileum indicate that organoids have potential to study intestinal innate immune processes.
Long-term neutralizing antibody dynamics against SARS-CoV-2 in symptomatic and asymptomatic infections: a systematic review and meta-analysis
Authors: Lu Wanying , Zheng Nan , Chen Xinhua , Sun Ruijia , Dong Jiayi , Ge Shijia , Deng Xiaowei , Yu Hongjie 
Published: December 2022

SummaryBackgroundThe kinetics of the neutralizing antibody response against SARS-CoV-2 is crucial for responding to the pandemic as well as developing vaccination strategies. We aimed to fit the antibody curves in symptomatic and asymptomatic individuals.MethodsWe systematically searched PubMed, Embase, Web of Science, and Europe PMC for articles published in English between Jan 1, 2020, and Oct 2, 2022. Studies evaluating neutralizing antibody from people who had a natural SARS-CoV-2 infection history were included. Study quality was assessed using a modified standardized scoring system. We fitted dynamic patterns of neutralizing antibody using a generalized additive model and a generalized additive mixed model. We also used linear regression model to conduct both univariate and multivariable analyses to explore the potential affecting factors on antibody levels. This study is registered with PROSPERO, CRD42022348636.Results7,343 studies were identified in the initial search, 50 were assessed for eligibility after removal of duplicates as well as inappropriate titles, abstracts and full-text review, and 48 studies (2,726 individuals, 5,670 samples) were included in the meta-analysis after quality assessment. The neutralization titer of people who infected with SARS-CoV-2 prototype strain peaked around 27 days (217.4, 95%CI: 187.0-252.9) but remained below the Omicron BA.5 protection threshold all the time after illness onset or confirmation. Furthermore, neither symptomatic infections nor asymptomatic infections could provide over 50% protection against Omicron BA.5 sub-lineage. It also showed that the clinical severity and the type of laboratory assays may significantly correlated with the level of neutralizing antibody.ConclusionsThis study provides a comprehensive mapping of the dynamic of neutralizing antibody against SARS-CoV-2 prototype strain induced by natural infection and compared the dynamic patterns between prototype and variant strains. It suggests that the protection probability provided by natural infection is limited. Therefore, timely vaccination is necessary for both previously infected symptomatic and asymptomatic individuals.
Characterization of Lean Six Sigma projects in healthcare settings: empirical research
Authors: Sordan Juliano Endrigo , Marinho Clésio Aparecido , Oprime Pedro Carlos , Pimenta Márcio Lopes , Andersson Roy 
Published: December 2022

PurposeThis paper aims to characterize a sample of Lean Six Sigma (LSS) projects in healthcare settings and discuss some specificities of operational excellence (OPEX) initiatives in hospitals and healthcare organizations in the USA.Design/methodology/approachA content analysis involving a sample of 23 documents shared by US hospitals was performed in order to achieve the research objectives. Such analysis was based on a conceptual framework developed from the literature review. It was also applied to a quantitative approach, including descriptive statistics, hypothesis testing and correspondence analysis that supported the research.FindingsMost LSSH projects were focused on business transformation and strategic improvements. Simple techniques and tools were predominant such as descriptive statistics, process mapping, 5S and spaghetti charts, usually implemented by Green Belts and Black Belts through the define, measure, analyze, improve and control (DMAIC) method. In addition to the expressive findings reported, these projects' results have been aligned with lead time and operational cost reduction, quality improvement and capacity increase.Research limitations/implicationsThe study adds knowledge to the OPEX literature by analyzing the Lean Six Sigma healthcare (LSSH) in hospitals and healthcare institutions in the USA. It also demonstrates that different approaches, such as the kaizen event and DMAIC project show different results according to some techniques and tools applied in the hospital environment.Originality/valueThe empirical evidence presented in this study provides scenery of the LSS practices in the healthcare settings, highlighting the implementation areas, outcomes, tools and techniques mostly used in the North American healthcare institutions.
Evaluation of success factors to implement digitalization in the construction industry
Authors: Bajpai Avirag , Misra Subhas C. 
Published: December 2022

Purpose
This study aims to identify and rank the key success factors linked with digitalization in the Indian construction sector. Because the construction firms in India are in the early stages of implementing digitalization in their operations, it provides a framework from which they may focus on the effectiveness of digitalization.

Design/methodology/approach
This research study examines 12 success factors related to digitalization in construction, which are derived from various sectors. Furthermore, experts from the construction industry and academia have validated these factors with respect to the Indian construction sector. The multi-criteria decision-making techniques are further used to examine the interrelationship, ranking and weightage of digitalization success. Finally, the success factors are validated through a questionnaire-based empirical study followed by ranking using a t-test. The results from both approaches (company-specific and generalized) are compared and discussed.

Findings
This research identifies that selecting appropriate digital methods and techniques is a critical success factor as far as digitalization in the Indian construction scenario is concerned. Besides that, continuous monitoring and control in digital implementation significantly impact other factors.

Research limitations/implications
While similar results are obtained from approaches adopted in the study, a few success factors appear to differ in terms of their ranking position. Further studies can explore the finer details that can explain the behavior pattern. This study can also be extended by assessing the structural relationship among the identified factors that can throw more light on the dynamics of the continuation of digitalization in construction which can further help in formulating policies or digitalization rollout.

Practical implications
The outcome of this study sheds light on construction business knowledge by stressing key success elements connected to digitalization in construction processes in the Indian construction sector. Moreover, this study shows that the success of digitalization in construction is similar to that of transformation in the information technology industry, where adopting suitable digital methods and techniques plays a vital role in the transformation process.

Originality/value
Despite the multiple benefits of construction digitalization, limited research focuses on digitalization success factors, making this study unique. Furthermore, this study demonstrates that integrating Fuzzy decision-making trial and evaluation laboratory and maximum mean de-entropy approaches may be used to successfully prioritize success factors in the nascent stage of construction digitalization.
When feeling good counts! Impact of consumer gratitude and life satisfaction in access-based services
Authors: Chou Cindy Yunhsin , Leo Wei Wei Cheryl , Tsarenko Yelena , Chen Tom 
Published: December 2022

Purpose
Informed by the broaden-and-build theory of emotions, this study aims to investigate the relationships between consumers’ motives and personal and social outcomes in access-based services (ABS). Further, drawing on territorial behaviour literature, the second goal of this research is to test the moderating effects of psychological ownership on the relationships between personal outcomes and consumer territorial behaviour.

Design/methodology/approach
This research comprises a quantitative online survey complemented by a qualitative interview study. The quantitative study employed an online consumer panel survey of 317 samples. Later, the qualitative study sought additional insights into the economic benefit motives and manifestation of territorial behaviour of bicycle-sharing users to enrich the results of quantitative study. The quantitative data were analysed using structural equation modelling, and the interviews were transcribed and analysed using an inductive and deductive thematic analysis.

Findings
The results indicated that specific motives significantly affected certain personal outcomes. Namely, economic benefit, enjoyment and reputation motives drove life satisfaction, while enjoyment, sustainability and social relationships promoted feelings of gratitude. Furthermore, life satisfaction positively affected consumer cooperation, helping other consumers and territorial behaviour. In contrast, feelings of gratitude had a positive relationship with cooperation and helping other consumers, but a negative one with territorial behaviour. Additional examination revealed that consumers’ psychological ownership of the shared bicycle in an ABS model moderated the effect of gratitude on consumer territorial behaviour.

Research limitations/implications
This study offers and tests a model on ABS in the context of bicycle-sharing services. Thus, it presents avenues to test the model on other ABS, e.g. clothing or home sharing.

Practical implications
Managers in ABS can foster positive emotional states of gratitude and life satisfaction that will inevitably promote consumer cooperation and helping behaviour.

Originality/value
This study is among the first to propose and examine a model that tests the relationships between consumers’ motives and personal and social outcomes in ABS.
The festival customer experience: a conceptual framework
Authors: Fernandes Jovan Velroy , Krolikowska Ewa 
Published: December 2022

PurposeThe purpose of this paper is to contribute to the conceptualisation of the festival customer experience by proposing a new framework based on three interrelated concepts: event design, social environment and digital environment.Design/methodology/approachThe authors use a theory adaptation research design to adapt an existing customer experience framework to the specific context of festival customer experience based on the literature on customer experience and experiential marketing within events, festivals, tourism and leisure.FindingsBased on this new conceptual framework, the authors identify interrelationships between event design, social environment and digital environment which can be managed by festival organisers to improve the customer experience.Research limitations/implicationsThis study’s analysis identifies five areas which are crucial for managing the contemporary festival customer experience. It offers researchers a conceptual framework for further development.Originality/valueThe paper proposes a new conceptual framework for festival customer experience which can be used to improve brand experiences at festivals. This is an emerging area which warrants further attention since festivals provide a valuable opportunity for brands to engage and build relationships with prospective and existing customers. This study is the first to combine insights from the interrelationships between event design, digital environment and social environment to better understand how to improve the management of brand experiences at festivals.
The effect of Chinese foreign direct investment on Africa's industrialization process
Authors: Darko Eugene Misa , Xu Kangning 
Published: December 2022

PurposeThis study empirically investigates the long-run and interactive effect of Chinese foreign direct investment (CFDI) on Africa's industrialization process.Design/methodology/approachThe authors employed industry and manufacturing value-added (% GDP) as the dependent variables and applied the two-step GMM and panel-corrected standard errors' (PCSE) techniques involving a panel of 49 African countries from 2003 to 2020.FindingsThe industry value-added (% GDP) results show that the presence of CFDI propels industrial productivity by contributing to value-addition in the short and long run. Moreover, the study shows that the magnitude of the CFDI effect on industrialization is pronounced in the short-run when it is associated with labor and natural resources. This result reveals efficiency-seeking behavior of CFDI and the CFDI-Africa industrialization nexus is not primarily resource-driven. More importantly, the authors found human capital, electricity and political stability, as primary factors that magnify CFDI's effect on industrialization in the short and long run.Originality/valueThis study is the first to use macro-level data to empirically investigate and find the significant effect of CFDI on Africa's industrialization in the long run. More importantly, the authors investigated channels through which CFDI magnifies industrialization in Africa in the short and long run.