bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automatic Detection and Classification of Radio Galaxy Images by Deep Learning
Authors: Zhang Zhen , Jiang Bin , Zhang Yanxia 
Published: June 2022

Abstract
Surveys conducted by radio astronomy observatories, such as SKA, MeerKAT, Very Large Array, and ASKAP, have generated massive astronomical images containing radio galaxies (RGs). This generation of massive RG images has imposed strict requirements on the detection and classification of RGs and makes manual classification and detection increasingly difficult, even impossible. Rapid classification and detection of images of different types of RGs help astronomers make full use of the observed astronomical image data for further processing and analysis. The classification of FRI and FRII is relatively easy, and there are more studies and literature on them at present, but FR0 and FRI are similar, so it is difficult to distinguish them. It poses a greater challenge to image processing. At present, deep learning has made breakthrough progress in the field of image analysis and processing and has preliminary applications in astronomical data processing. Compared with classification algorithms that can only classify galaxies, object detection algorithms that can locate and classify RGs simultaneously are preferred. In target detection algorithms, YOLOv5 has outstanding advantages in the classification and positioning of small targets. Therefore, we propose a deep-learning method based on an improved YOLOv5 object detection model that makes full use of multisource data, combining FIRST radio with SDSS optical image data, and realizes the automatic detection of FR0, FRI, and FRII RGs. The innovation of our work is that on the basis of the original YOLOv5 object detection model, we introduce the SE Net attention mechanism, increase the number of preset anchors, adjust the network structure of the feature pyramid, and modify the network structure, thereby allowing our model to demonstrate galaxy classification and position detection effects. Our improved model produces satisfactory results, as evidenced by experiments. Overall, the mean average precision (mAP@0.5) of our improved model on the test set reaches 89.4%, which can determine the position (R.A. and decl.) and automatically detect and classify FR0s, FRIs, and FRIIs. Our work contributes to astronomy because it allows astronomers to locate FR0, FRI, and FRII galaxies in a relatively short time and can be further combined with other astronomically generated data to study the properties of these galaxies. The target detection model can also help astronomers find FR0s, FRIs, and FRIIs in future surveys and build a large-scale star RG catalog. Moreover, our work is also useful for the detection of other types of galaxies.
Using Non-negative Matrix Factorization to Improve Calibration of the Keck OSIRIS Integral Field Spectrograph
Authors: Horstman Katelyn , Fitzgerald Michael P. , Lyke James E. , Yeh Sherry C. C. , Chu Devin S. 
Published: June 2022

Abstract
Integral Field Spectrographs (IFS) often require non-trivial calibration techniques to process raw data. The OH Suppressing InfraRed Imaging Spectrograph at the W. M. Keck Observatory is a lenslet-based IFS that requires precise methods to associate the flux on the detector with both a wavelength and a position on the detector. During calibration scans, a single column lenslet mask is utilized to keep light from adjacent lenslet columns separate from the primary lenslet column, in order to uniquely determine spectral response of individual lenslets on the detector. Despite employing a single column lenslet mask, an issue associated with such calibration schemes may occur when light from adjacent masked lenslet columns leaks into the primary lenslet column. Incorrectly characterizing the flux due to additional light in the primary lenslet column results in one form of crosstalk between lenslet columns, which most clearly manifest as non-physical artifacts in the spectral dimension of the reduced data. We treat the problem of potentially blended calibration scans as a source separation problem and implement Non-negative Matrix Factorization (NMF) as a way to separate blended calibration scan spectra. After applying NMF to calibration scan data, extracted spectra from calibration scans show reduced crosstalk of up to 26.7% ± 0.5% while not adversely impacting the signal-to-noise ratio. Additionally, we determined the optimal number of calibration scans per lenslet column needed to create NMF factors, finding that greatest reduction crosstalk occurs when NMF factors are created using one calibration scan per lenslet column.
On scattering and damping of toroidal Alfvén eigenmode by drift wave turbulence
Authors: Chen Liu , Qiu Zhiyong , Zonca Fulvio 
Published: June 2022

Abstract
We demonstrate analytically that, in toroidal plasmas, scattering by drift wave turbulence could lead to appreciable damping of toroidal Alfvén eigenmodes via generation of short-wavelength electron Landau damped kinetic Alfvén waves. A corresponding analytic expression of the damping rate is derived, and found to be, typically, comparable to the linear drive by energetic particles. The implications of this novel mechanism on the transport and heating processes in burning plasmas are also discussed.
Research with African Adolescents: Critical Epistemologies and Methodological Considerations
Authors: Manful Kuukuwa O 
Published: June 2022

ABSTRACT
Whereas much research with adolescents in Africa engages them mainly with respect to issues limited and explicitly related to youth, this research note makes epistemic and methodological arguments for engaging adolescents more broadly in our research about Africa. I present a practical application of research design and methods based on these arguments through a study with adolescents in a secondary school in Ghana in which I engendered their enthusiastic participation in the research process. Through this, I demonstrate how taking a critical approach to epistemologies and methodologies in research with young participants can expand and enrich our knowledge of and about the continent.
Cervical immune activation during the luteal phase may compromise subsequent trans-cervical ram sperm transport
Authors: Abril-Parreño Laura , Krogenæs Anette Kristine , Druart Xavier , Cormican Paul , Fair Sean , Meade Kieran G 
Published: June 2022

Abstract
Worldwide, cervical artificial insemination using frozen–thawed semen yields low pregnancy rates. The only exception to this is in Norway, where vaginal insemination with frozen–thawed semen yields pregnancy rates in excess of 60% and which has been attributed to the specific ewe breed used. Our previous work demonstrated differences in cervical gene expression at the follicular phase of the estrous cycle in ewe breeds with known differences in pregnancy rates. In this study, we characterized the cervical transcriptome of the same ewe breeds [Suffolk, Belclare, Fur, and Norwegian White Sheep (NWS)] during the luteal phase, as an optimal environment at the luteal phase could better prepare the cervix for sperm migration through the cervix at the subsequent follicular phase. High-quality RNA extracted from postmortem cervical tissue was analyzed by RNA sequencing. After stringent filtering, 1051, 1924, and 611 differentially expressed genes (DEGs) were detected in the low-fertility Suffolk breed compared with Belclare, Fur, and NWS, respectively. Gene ontology analysis identified increased humoral adaptive immune response pathways in Suffolk. Increased expression of multiple immune genes supports the presence of an active immune response in the cervix of Suffolk ewes, which differentiates them significantly from the other three ewe breeds. Inflammatory pathways were upregulated in the Suffolk, resulting in higher expression of the potent pro-inflammatory cytokines. Therefore, higher levels of pro-inflammatory cytokines indicate unresolved inflammation in the cervix of the low-fertility Suffolk breed that could contribute to reduced cervical sperm transport in the next follicular phase.
Expression patterns and the roles of phosphatidylinositol phosphatases in testis
Authors: Ceyhan Yasemin , Zhang Manqi , Sandoval Carlos G , Agoulnik Alexander I , Agoulnik Irina U 
Published: June 2022

AbstractPhosphoinositides (PIs) are relatively rare lipid components of the cellular membranes. Their homeostasis is tightly controlled by specific PI kinases and PI phosphatases. PIs play essential roles in cellular signaling, cytoskeletal organization, and secretory processes in various diseases and normal physiology. Gene targeting experiments strongly suggest that in mice with deficiency of several PI phosphatases, such as Pten, Mtmrs, Inpp4b, and Inpp5b, spermatogenesis is affected, resulting in partial or complete infertility. Similarly, in men, loss of several of the PI phosphatases is observed in infertility characterized by the lack of mature sperm. Using available gene expression databases, we compare the expression of known PI phosphatases in various testicular cell types, infertility patients, and mouse age-dependent testicular gene expression, and discuss their potential roles in testis physiology and spermatogenesis.
Perioperative care bundles for the prevention of surgical-site infections: meta-analysis
Authors: Wolfhagen Niels , Boldingh Quirine J J , Boermeester Marja A , de Jonge Stijn W 
Published: June 2022

Abstract

Background
Care bundles are used widely to prevent surgical-site infections (SSIs). Recent systematic reviews suggested larger effects from bundles with more interventions. These reviews were largely based on uncontrolled before–after studies and did not consider their biases. The aim of this meta-analysis was to determine the effectiveness of care bundles to prevent SSIs and explore characteristics of effective care bundles.

Methods
A systematic review, reanalysis, and meta-analysis of available evidence were undertaken. RCTs, controlled before–after studies, and uncontrolled before–after studies with sufficient data for reanalysis as interrupted time series studies (ITS) were eligible. Studies investigating the use of a care bundle, with at least one intraoperative intervention, compared with standard care were included.

Results
Four RCTs, 1 controlled before–after study, and 13 ITS were included. Pooled data from RCTs were heterogeneous. Meta-analysis of ITS resulted in a level change of −1.16 (95 per cent c.i.−1.78 to −0.53), indicating a reduction in SSI. The effect was larger when the care bundle comprised a higher proportion of evidence-based interventions. Meta-regression analyses did not show statistically significant associations between effect estimates and number of interventions, number of evidence-based interventions, or proportion of evidence-based interventions.

Conclusion
Meta-analysis of ITS indicated that perioperative care bundles prevent SSI. This effect is inconsistent across RCTs. Larger bundles were not associated with a larger effect, but the effect may be larger if the care bundle contains a high proportion of evidence-based interventions. No strong evidence for characteristics of effective care bundles was identified.
Axillary surgery after neoadjuvant therapy in initially node-positive breast cancer: international EUBREAST survey
Authors: Gasparri Maria Luisa , de Boniface Jana , Poortmans Philip , Gentilini Oreste D , Kaidar-Person Orit , Banys-Paluchowski Maggie , Di Micco Rosa , Niinikoski Laura , Murawa David , Bonci Eduard Alexandru , Pasca Andrei , Rubio Isabel T , Karadeniz Cakmak Guldeniz , Kontos Michalis , Kühn Thorsten 
Published: June 2022

Abstract

Background
There is no consensus on axillary management after neoadjuvant therapy (NAT) in patients with clinically node-positive (cN+) breast cancer. To investigate current clinical practice, an international survey was conducted among breast surgeons and radiation oncologists. The aim of the first part of the survey was to provide a snapshot of international discrepancies regarding axillary surgery in this context.

Methods
The European Breast Cancer Research Association of Surgical Trialists (EUBREAST) developed a web-based survey containing 39 questions describing clinical scenarios in the setting of axillary management in patients with cN1 disease converting to ycN0 after NAT. The survey was then distributed to breast surgeons and radiation oncologists via 14 breast cancer societies between April and October 2021.

Results
Responses from 349 physicians in 45 countries were recorded. The most common post-NAT axillary surgery in patients with cN1 disease converting to ycN0 was targeted axillary dissection (54.2 per cent), followed by sentinel lymph node biopsy (SLNB) alone (20.9 per cent), level 1–2 axillary lymph node dissection (ALND) (18.4 per cent), level 1–3 ALND (4 per cent), and targeted lymph node biopsy (2.5 per cent). For SLNB alone, dual tracers were most commonly used (62.3 per cent). Management varied widely in patients with ambiguous axillary status before initiation of treatment or a residual metastatic burden in the axilla after NAT. In patients with ycN+ tumours, ALND was the preferred surgical approach for 66.8 per cent of respondents.

Conclusion
These results highlight the wide heterogeneity in surgical approaches to the axilla after NAT. To standardize the guidelines, further data from clinical research are urgently needed, which underlines the importance of the ongoing AXSANA (EUBREAST-3) study.
Bicuspidization of a unicuspid valve using sliding plasty of a rudimentary right coronary cusp
Authors: Shraer Nathanael , Berrebi Alain , Biondi Raoul , Lansac Emmanuel 
Published: June 2022

Abstract
Unicuspid aortic valve repair relies on the principles of bicuspidization by creating a neo-commissure at 180° from the existing commissure, with pericardial patch interposition. We report a case of a 26-year-old patient with cor triatriatum and a severely regurgitating unicuspid valve. The left atrium membrane was resected. Aortic valve repair was performed creating a neo-commissure using a sliding plasty of the rudimentary right coronary cusp and patch reconstruction of the anterior part of the non-coronary cusp, protected by external subvalvular annuloplasty and hemi-root remodelling. We detail a repair technique of a partial autologous reconstruction approach for bicuspidization.
Development and psychometric testing of the Heart-Healthy Information Questionnaire
Authors: Choo Jina , Noh Songwhi , Moon Jihyun , Shin Yura 
Published: June 2022

AbstractAimsThis study aimed to develop a reliable and valid scale, i.e. the Heart-Healthy Information Questionnaire (HHIQ).Methods and resultsThe HHIQ was developed in three phases: (i) creating the item pool, (ii) conducting a preliminary evaluating the items, and (iii) refining the scale and evaluating psychometric properties. An initial item pool of 77 items with a 3-point True/False format with a ‘Don’t know’ option was extracted from the literature review and 54 items reached content validity. The psychometric properties of HHIQ were tested with 1315 individuals without cardiovascular disease. By using the exclusion criteria of the difficulty index (&gt;0.95), discrimination index (&lt;10.0), and item-total correlation (tetrachoric coefficient &lt;0.2), 50 items were finally selected. The construct validity was determined by using the known-groups validation: Individuals (n = 107) who were educated with heart-healthy education sessions showed significantly higher scores of the HHIQ than those (n = 107) who were not educated (P = 0.015). The Kuder–Richardson formula 20 coefficient indicated good internal consistency (0.85), and the test–retest reliability coefficient with a 15-day interval also indicated good stability (0.78). A total score of the HHIQ was significantly correlated with a total score of the Evaluation Tool for Metabolic Syndrome Modification Lifestyles (ρ = 0.23, P &lt; 0.001).ConclusionThe HHIQ showed good psychometric properties of validity and reliability and may be useful to evaluate the knowledge levels of heart-healthy information in the areas of cardiovascular disease prevention.
A Decade of GigaScience: Women in Science: Past, Present, and Future
Authors: Liu Lijun , Jovic Dragomirka , Goodman Laurie 
Published: June 2022

Abstract
Over the last decade, women have made decisive advances in increasing equality in science, technology, engineering, and medicine (STEM), but they still do not rival that of men. Many mechanisms to reduce gender discrimination have been addressed; however, little to nothing has been done to tackle the differences in the amount of time women spend on responsibilities at home. This has never been more apparent than during the COVID-19 pandemic. After a decade of advances promoting women, the last two years have seen these advances halted, and the long-term implications for women in STEM will be substantial. Moving forward, career advancement and funding mechanisms need to be adjusted to not just help women catch up, but to become a permanent support mechanism for women in the workplace. The higher amount of responsibilities at home and lack of support for women is not reserved for times of international upheaval: it has just become more apparent.
Severe acute respiratory infection surveillance in Brazil: the role of public, private and philanthropic healthcare units
Authors: Silva Amauri Duarte da , Veiga Ana Beatriz Gorini da , Cruz Oswaldo Gonçalves , Bastos Leonardo Soares , Gomes Marcelo Ferreira da Costa 
Published: June 2022

Abstract
Epidemiological surveillance and notification of respiratory infections are important for management and control of epidemics and pandemics. Fact-based decisions, like social distancing policies and preparation of hospital beds, are taken based on several factors, including case numbers; hence, health authorities need quick access to reliable and well-analysed data. We aimed to analyse the role of the Brazilian public health system in the notification and hospitalization of patients with severe acute respiratory infection (SARI). Data of SARI cases in Brazil (2013–20) were obtained from SIVEP-Gripe platform, and legal status of each healthcare unit (HCU) responsible for case notification and hospitalization was obtained from the National Registry of Health Facilities (CNES) database. HCUs that are part of the hospital network were classified as ‘Public Administration’, ‘Business Entities’, ‘Philanthropic Entities’ or ‘Individuals’. SARI notification data from Brazilian macro-regions (North, Northeast, Midwest, Southeast and South) were analysed and compared between administrative spheres. This study reveals that hospitalizations due to SARI increased significantly in Brazil during the coronavirus disease 2019 (COVID-19) pandemic, especially in HCUs of Public Administration. In the Southeast and South, where incidence of SARI is high, philanthropic HCUs also contribute to hospitalization of SARI cases and attend up to 7.4% of the cases notified by the Public Administration. The number of cases is usually lower in other regions, but in 2020 the Northeast showed more hospitalizations than the South. In the South, SARI season occurs later; however, in 2020, an early peak was observed because of COVID-19. Notably, the contribution of each administrative sphere that manages hospital networks in Brazil in the control and management of SARI varies between regions. Our approach will allow managers to assess the use of public resources, given that there are different profiles of healthcare in each region of Brazil and that the public health system has a major role in notifying and attending SARI cases.
Mutant VPS35-D620N induces motor dysfunction and impairs DAT-mediated dopamine recycling pathway
Authors: Huang Yi , Huang Heng , Zhou Leping , Li Jiawei , Chen Xiang , Thomas Joseph , He Xiaofei , Guo Wenyuan , Zeng Yixuan , Low Boon Chuan , Liang Fengyin , Zeng Jinsheng , Ross Christopher A , Tan Eng-King , Smith Wanli , Pei Zhong 
Published: June 2022

Abstract
The D620N mutation in vacuolar protein sorting protein 35 (VPS35) gene has been identified to be linked to late onset familial Parkinson disease (PD). However, the pathophysiological roles of VPS35-D620N in PD remain unclear. Here, we generated the transgenic Caenorhabditis elegans overexpressing either human wild type or PD-linked mutant VPS35-D620N in neurons. C. elegans expressing VPS35-D620N, compared with non-transgenic controls, showed movement disorders and dopaminergic neuron loss. VPS35-D620N worms displayed more swimming induced paralysis but showed no defects in BSR assays, thus indicating the disruption of dopamine (DA) recycling back inside neurons. Moreover, VPS35 formed a protein interaction complex with DA transporter (DAT), RAB5, RAB11 and FAM21. In contrast, the VPS35-D620N mutant destabilized these interactions, thus disrupting DAT transport from early endosomes to recycling endosomes, and decreasing DAT at the cell surface. These effects together increased DA in synaptic clefts, and led to dopaminergic neuron degeneration and motor dysfunction. Treatment with reserpine significantly decreased the swimming induced paralysis in VPS35-D620N worms, as compared with vehicle treated VPS35-D620N worms. Our studies not only provide novel insights into the mechanisms of VPS35-D620N-induced dopaminergic neuron degeneration and motor dysfunction via disruption of DAT function and the DA signaling pathway but also indicate a potential strategy to treat VPS35-D620N-related PD and other disorders.
Protein misfolding and clearance in the pathogenesis of a new infantile onset ataxia caused by mutations in PRDX3
Authors: Martínez-Rubio Dolores , Rodríguez-Prieto Ángela , Sancho Paula , Navarro-González Carmen , Gorría-Redondo Nerea , Miquel-Leal Javier , Marco-Marín Clara , Jenkins Alison , Soriano-Navarro Mario , Hernández Alberto , Pérez-Dueñas Belén , Fazzari Pietro , Aguilera-Albesa Sergio , Espinós Carmen 
Published: June 2022

Abstract
Peroxiredoxin 3 (PRDX3) encodes a mitochondrial antioxidant protein, which is essential for the control of reactive oxygen species homeostasis. So far, PRDX3 mutations are involved in mild-to-moderate progressive juvenile onset cerebellar ataxia. We aimed to unravel the molecular bases underlying the disease in an infant suffering from cerebellar ataxia that started at 19 months old and presented severe cerebellar atrophy and peripheral neuropathy early in the course of disease. By whole exome sequencing, we identified a novel homozygous mutation, PRDX3 p.D163E, which impaired the mitochondrial ROS defense system. In mouse primary cortical neurons, the exogenous expression of PRDX3 p.D163E was reduced and triggered alterations in neurite morphology and in mitochondria. Mitochondrial computational parameters showed that p.D163E led to serious mitochondrial alterations. In transfected HeLa cells expressing the mutation, mitochondria accumulation was detected by correlative light electron microscopy. Mitochondrial morphology showed severe changes, including extremely damaged outer and inner membranes with a notable cristae disorganization. Moreover, spherical structures compatible with lipid droplets were identified, which can be associated with a generalized response to stress and can be involved in the removal of unfolded proteins. In the patient’s fibroblasts, PRDX3 expression was nearly absent. The biochemical analysis suggested that the mutation p.D163E would result in an unstable structure tending to form aggregates that trigger unfolded protein responses via mitochondria and endoplasmic reticulum. Altogether, our findings broaden the clinical spectrum of the recently described PRDX3-associated neurodegeneration and provide new insight into the pathological mechanisms underlying this new form of cerebellar ataxia.