bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Bibliometric and Visualized Analysis of Uremic Cardiomyopathy From 1990 to 2021
Authors: Bao Jing-Fu , Hu Pan-Pan , She Qin-Ying , Zhang Difei , Mo Jia-Ju , Li Aiqing 
Published: July 2022

BackgroundUremic cardiomyopathy is commonly presented in chronic kidney disease (CKD), and it severely affects the prognosis of patients with CKD. In the past few decades, the investigation of uremic cardiomyopathy has developed rapidly. However, no report has summarized the situation of uremic cardiomyopathy research to date. This study aimed to evaluate the state of uremic cardiomyopathy research in the last 30 years and identify important topics and achievements, as well as emerging trends through bibliometric analysis.Materials and MethodsPublications related to uremic cardiomyopathy were collected from Science Citation Index Expanded. HistCite, VOSviewer, CiteSpace, and the Bibliometrix Package were used for bibliometric analysis and visualization, including the analysis of the overall distribution of the annual publication, leading countries, and active institutions and authors, core journals, co-cited references, and keywords.ResultsA total of 2,403 studies related to uremic cardiomyopathy were obtained, and progress related to uremic cardiomyopathy was slower in past 3 years. A total of 10,077 authors from 2,697 institutions in 89 countries or regions reported investigations on uremic cardiomyopathy. The United States of America was the most productive and the most cited country. Myles Wolf, Joseph I Shapiro, and Carmine Zoccali published most articles in uremic cardiomyopathy, and journals in nephrology possessed core status in the field. Phosphate metabolism was the hotspot in uremic cardiomyopathy research in recent years, and future progress may concentrate on phosphate metabolism, endogenous natriuretic factors, and novel biomarkers.ConclusionThe United States of America and European countries played central roles in uremic cardiomyopathy research, while Chinese scholars should be more involved in this field. Global publications on uremic cardiomyopathy have entered platform stage, and the fibroblast growth factor-23-klotho axis remained a hotspot in this field. Endogenous natriuretic factors and novel biomarkers may be potential directions in future investigations.
Altered Expressions of Transfer RNA-Derived Small RNAs and microRNAs in the Vitreous Humor of Proliferative Diabetic Retinopathy
Authors: Yang Yan , Yue Wenyun , Wang Nan , Wang Zicong , Li Bingyan , Zeng Jun , Yoshida Shigeo , Ding Chun , Zhou Yedi 
Published: July 2022

PurposeWe sought to reveal the expression profiles of transfer RNA-derived small RNAs (tsRNAs) and microRNAs (miRNAs) in the vitreous humor of patients with proliferative diabetic retinopathy (PDR).MethodsVitreous humor samples were obtained from PDR patients and a control group for this study. Sequencing of small RNAs was conducted to assess the expression profiles of tsRNAs and miRNAs in both groups, which was followed by validation using reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR). Bioinformatics analyses were conducted to predict the target genes and their potential biological functions and signaling pathways.ResultsA total of 37 tsRNAs and 70 miRNAs with significant differences were screened out from the vitreous humor samples of PDR patients compared to controls. Following validation by RT-qPCR, the target genes of the validated tsRNAs and miRNAs were predicted, and Gene Ontology analysis indicated that the target genes of the tsRNAs were most enriched in the cellular macromolecule metabolic process, cytoplasm, and ion-binding, while those of the miRNAs were most abundant in the regulation of major metabolic process, cytoplasm, and protein-binding. In addition, Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that the target genes of said tsRNAs and miRNAs were most enriched in the adenosine monophosphate-activated protein kinase signaling pathway and Th17 cell differentiation, respectively.ConclusionsThe present study identified altered tsRNAs and miRNAs in vitreous humor samples of PDR patients, which may play important roles in the pathogenesis of PDR and could be considered potential therapeutic targets in the treatment of PDR.
Reference Data of Phase Angle Using Bioelectrical Impedance Analysis in Overweight and Obese Chinese
Authors: Fu Luo , Ren Zhengyun , Liu Xiaoxiao , Wu Nianwei , Zhao Kang , Luo Guangping , Yang Huawu , Zhang Yuanchuan , Yan Tong , Liu Yanjun , Zhang Tongtong 
Published: July 2022

IntroductionPhase angle (PhA) is a ratio of reactance and resistance {arctangent (reactance (Xc)/resistance (R)) × (180°/π)}, which can be obtained by bioelectrical impedance analysis (BIA). PhA indicates cellular health and integrity, and it is also considered as a prognostic tool in medical disorders and an indicator of nutritional status (especially of muscle quality) in patients with obesity. However, PhA has limited usefulness in clinical practice because of a lackness of reference values for Chinese overweight and obese populations. The main aim of this study was to show PhA reference data in different age and BMI groups by sex. In addition, we also study the association of age, sex, and BMI on PhA.MethodsA total of 1729 overweight and obese participants were included in this study. PhA and body composition were measured using segmental multifrequency BIA. Differences in mean values for variables were tested by one-way analysis of variance. Multiple regression analysis was used to assess the associations of PhA with age, sex and BMI.ResultsMultiple regression analysis showed that age, sex and BMI were significant (P &lt; 0.05) independent influence factors of PhA in Chinese overweight and obese adults when age and BMI were continues variables. The mean PhA value for all participants was 5.5°. Mean BMI, age, weight, height and 50kHz-PhA were significantly higher (P &lt; 0.001) in male participants than female ones. In age groups and BMI groups, mean 50kHz-PhA was significantly higher (P &lt; 0.005) in male participants than female ones. When age groups and BMI groups were categorical variables, multiple regression analysis showed that different age groups (46–55 years and ≥ 56 years) had a significantly lower (P &lt; 0.005) PhA as compared with the baseline group (18-25 years) and different BMI groups (≥ 28 kg/m2) had a significantly higher (P &lt; 0.05) PhA as compared with the baseline group (24–27.9 kg/m2).ConclusionPhA differed according to age, sex and BMI. Reference data in this study can be taken into consideration when deriving the reference values for overweight and obese Chinese populations.
Nacre-Like Reduced Graphene Oxide/Silver Nanowire Paper With Reinforced Chemical and Electrical Stability for Fast Electrical Heating System
Authors: Zou Xiuxiu , Shen Kuizhong , Lin Yan , Liang Fangmin , Sun Enhui , Wu Yiqiang , Fang Guigan 
Published: July 2022

Silver nanowire (AgNW) has excellent thermal conductivity, which is an ideal material for fabricating flexible electrical heating materials. However, the poor stability of AgNWs is far from meeting the requirements for the practical application of electrical heating materials. Herein, by imitating the layered structure of nacre, the reduced graphene oxide (rGO)/AgNWs paper with a nacre-like structure was successfully prepared using a simple gravity-induced deposition approach. The obtained rGO/AgNWs paper showed excellent electrical conductivity (19.61 Ω/sq) and good pattern adjustability at the rGO to AgNWs ratio of 1:1. More importantly, the rGO/AgNWs paper exhibited high resistance to oxygen and water vapor, thus realizing long-term stability and reliability. Moreover, the design of a nacre-like structure could improve the thermal management performances of rGO/AgNWs paper, making it achieve a high Joule heating temperature (∼215.83°C) at low supplied voltages (3 V), the rapid response time (∼12 s) and long-term heating stability. These results indicate that the prepared rGO/AgNWs paper promises to be an electrical heating component with high chemical stability for thermal management electric materials.
On the Method of Design Drift-Ice Concentration and Floe Area for New-Energy Structures in Ice-Infested Nearshore Areas of the Bohai Sea, China
Authors: Li Zhijun , Xiu Yuanren , Wang Qingkai , Li Ge , Lu Peng , Zhong Shan , Chen Xue 
Published: July 2022

To provide basic drift-ice parameters for new-energy structures in ice-infested nearshore waters, an estimation method of the design drift-ice concentration and floe area was established. A total of 700 satellite images in winters from 2010 to 2021 were used to obtain the drift-ice concentration and floe area from 26 sites in the Bohai Sea. The floe area with 90% cumulative probability was selected as the characteristic floe area in each satellite image. Furthermore, the water temperature threshold ranging from −1.6 °C to −0.5 °C was adopted by considering the drift-ice freezing/melting states because of different salinity values in nearshore waters. The upper limit values of the ice concentration and characteristic floe area at the lowest water temperature of −1.6 °C were finally used as the design drift-ice indexes. The maximum design ice concentrations (floe area) in the Liaodong Bay, Bohai Bay, and Laizhou Bay were 96% (0.43 km2), 91% (0.39 km2), and 87% (0.29 km2), respectively. The design ice concentration at the bay bottom was higher than that near the mouth. The design floe area in the Liaodong Bay and Bohai Bay increased with latitudes, but the trend was opposite in the Laizhou Bay. The method developed in the current study has universal applicability, which can be extended to other ice-cover waters and specific structure designs by adjusting the cumulative probability threshold and the water temperature threshold.
Chile and its Potential Role Among the Most Affordable Green Hydrogen Producers in the World
Authors: Acosta Kevin , Salazar Iván , Saldaña Manuel , Ramos Jahir , Navarra Alessandro , Toro Norman 
Published: July 2022

As result of the adverse effects caused by climate change, the nations have decided to accelerate the transition of the energy matrix through the use of non-conventional sources free of polluting emissions. One of these alternatives is green hydrogen. In this context, Chile stands out for the exceptional climate that makes it a country with a lot of renewable resources. Such availability of resources gives the nation clear advantages for hydrogen production, strong gusts of wind throughout the country, the most increased solar radiation in the world, lower cost of production of electrical supplies, among others. Due to this, the nation would be between the lowest estimated cost for hydrogen production, i.e., 1.5 USD/kg H2 approximately, scenario that would place it as one of the cheapest green hydrogen producer in the world.
Boosted Regression Tree Algorithm for the Reconstruction of GRACE-Based Terrestrial Water Storage Anomalies in the Yangtze River Basin
Authors: Dannouf Ramia , Yong Bin , Ndehedehe Christopher E. , Correa Fabio M. , Ferreira Vagner 
Published: July 2022

The terrestrial water storage anomaly (TWSA) from the previous Gravity Recovery and Climate Experiment (GRACE) covers a relatively short period (15 years) with several missing periods. This study explores the boosted regression trees (BRT) and the artificial neural network (ANN) to reconstruct the TWSA series between 1982 and 2014 over the Yangtze River basin (YRB). Both algorithms are trained with several hydro-climatic variables (e.g., precipitation, soil moisture, and temperature) and climate indices for the YRB. The results from this study show that the BRT is capable of reconstructing TWSA and shows Nash–Sutcliffe efficiency (NSE) of 0.89 and a root-mean-square error (RMSE) of 18.94 mm during the test stage, outperforming ANN in about 2.3% and 7.4%, respectively. As a step further, the reliability of this technique in reconstructing TWSA beyond the GRACE era was also evaluated. Hence, a closed-loop simulation using the artificial TWSA series over 1982–2014 under the same scenarios for the actual GRACE data shows that BRT can predict TWSA (NSE of 0.92 and RMSE of 6.93 mm). Again, the BRT outperformed the ANN by approximately 1.1% and 5.3%, respectively. This study provides a new perspective for reconstructing and filling the gaps in the GRACE–TWSA series over data-scarce regions, which is desired for hydrological drought characterization and environmental studies. BRT offers such an opportunity for the GRACE Follow-On mission to predict 11 months of missing TWSA data by relying on a limited number of predictive variables, hence being adjudged to be more economical than the ANN.
Disentangling Forest Dynamics for Litter Biomass Production in a Biosphere Reserve in Central India
Authors: Thakur Tarun Kumar , Eripogu Kiran Kumar , Thakur Anita , Kumar Amit , Bakshi Sanjeev , Swamy S. L. , Bijalwan Arvind , Kumar Munesh 
Published: July 2022

Investments in energy sources are scaling up across India to improve climate security and further mitigate future climate change. Forest biomass and litterfall pattern play an important role in the sustainable management of forests and the efficient utilization of resources. This study investigates the seasonal litterfall biomass pattern for five consecutive years (2015–2019) in four different vegetation types in Central India (AABR) using the litter traps method on the forest floor. An ANOVA model was adopted to infer the effects of forest types, litter types, and seasonality on litterfall production. The estimated mean litterfall of the dry tropical forest in Central India was recorded as 4.19 ± 0.305 Mg/ha/y where teak plantations contribute higher values compared to other studied vegetation types. A positive correlation was observed between the litterfall and nutrient storage with soil-adjusted vegetation index and other vegetation indices. The findings of litterfall pattern and turnover rate of nutrients indicated that the vegetation types of AABR have huge potential for carbon sequestration and help to achieve the Conference of the Parties (COP-26) goal of reducing regional and/or global climate change.
Imputation of Ancient Whole Genome Sus scrofa DNA Introduces Biases Toward Main Population Components in the Reference Panel
Authors: Erven J. A. M. , Çakirlar C. , Bradley D. G. , Raemaekers D. C. M. , Madsen O. 
Published: July 2022

Sequencing ancient DNA to high coverage is often limited by sample quality and cost. Imputing missing genotypes can potentially increase information content and quality of ancient data, but requires different computational approaches than modern DNA imputation. Ancient imputation beyond humans has not been investigated. In this study we report results of a systematic evaluation of imputation of three whole genome ancient Sus scrofa samples from the Early and Late Neolithic (∼7,100–4,500 BP), to test the utility of imputation. We show how issues like genetic architecture and, reference panel divergence, composition and size affect imputation accuracy. We evaluate a variety of imputation methods, including Beagle5, GLIMPSE, and Impute5 with varying filters, pipelines, and variant calling methods. We achieved genotype concordance in most cases reaching above 90%; with the highest being 98% with ∼2,000,000 variants recovered using GLIMPSE. Despite this high concordance the sources of diversity present in the genotypes called in the original high coverage genomes were not equally imputed leading to biases in downstream analyses; a trend toward genotypes most common in the reference panel is observed. This demonstrates that the current reference panel does not possess the full diversity needed for accurate imputation of ancient Sus, due to missing variations from Near Eastern and Mesolithic wild boar. Imputation of ancient Sus scrofa holds potential but should be approached with caution due to these biases, and suggests that there is no universal approach for imputation of non-human ancient species.
Pan-Cancer Analysis Identified Homologous Recombination Factor With OB-Fold (HROB) as a Potential Biomarker for Various Tumor Types
Authors: Liu Xianming , Wang Cunchuan 
Published: July 2022

Background: By recruiting the MCM8–MCM9 helicase to DNA damage site, the Homologous Recombination Factor With OB-Fold (HROB) is involved in the repair of inter-strand crosslink and homologous recombination. Previous studies have shown that HROB may play an oncogenic role by promoting cell proliferation and chemoresistance in several tumor types. However, the potential diagnostic and prognostic values of HROB have not been systemically explored in pan-cancer.Methods: We analyzed the expression pattern of HROB among tumor tissues and normal tissues in several public databases, including Human Protein Atlas and the Cancer Genome Atlas (TCGA) and investigated the association between the HROB expression and pathological stage and patient prognosis. We also analyzed the association between HROB expression and cancer stemness and immune infiltration of cancer-associated fibroblasts (CAFs) and CD8+ T cells in pan-cancer. Finally, we explored the potential biological function of HROB through pathway enrichment analysis.Results: In most tumor types, HROB is overexpressed in tumor tissues compared with non-tumor tissues. High HROB expression was correlated with poor prognosis and advanced pathological stages. HROB expression was robustly correlated with cancer stemness. Moreover, significant correlations between CAFs, CD8+ T-cell infiltration, and HROB expression were observed in several tumor types. Pathway enrichment analysis revealed that cell cycle and mitotic-regulated pathways were strongly enriched in HROB co-expressed genes.Conclusion: HROB may be a potential diagnostic and prognostic biomarker in pan-cancer, which may play a role in tumorigenesis and disease progression by affecting the cancer stemness of tumor tissues and immune cell infiltration.
Lymphocytic Airway Inflammation in Lung Allografts
Authors: Santos Jesse , Calabrese Daniel R. , Greenland John R. 
Published: July 2022

Lung transplant remains a key therapeutic option for patients with end stage lung disease but short- and long-term survival lag other solid organ transplants. Early ischemia-reperfusion injury in the form of primary graft dysfunction (PGD) and acute cellular rejection are risk factors for chronic lung allograft dysfunction (CLAD), a syndrome of airway and parenchymal fibrosis that is the major barrier to long term survival. An increasing body of research suggests lymphocytic airway inflammation plays a significant role in these important clinical syndromes. Cytotoxic T cells are observed in airway rejection, and transcriptional analysis of airways reveal common cytotoxic gene patterns across solid organ transplant rejection. Natural killer (NK) cells have also been implicated in the early allograft damage response to PGD, acute rejection, cytomegalovirus, and CLAD. This review will examine the roles of lymphocytic airway inflammation across the lifespan of the allograft, including: 1) The contribution of innate lymphocytes to PGD and the impact of PGD on the adaptive immune response. 2) Acute cellular rejection pathologies and the limitations in identifying airway inflammation by transbronchial biopsy. 3) Potentiators of airway inflammation and heterologous immunity, such as respiratory infections, aspiration, and the airway microbiome. 4) Airway contributions to CLAD pathogenesis, including epithelial to mesenchymal transition (EMT), club cell loss, and the evolution from constrictive bronchiolitis to parenchymal fibrosis. 5) Protective mechanisms of fibrosis involving regulatory T cells. In summary, this review will examine our current understanding of the complex interplay between the transplanted airway epithelium, lymphocytic airway infiltration, and rejection pathologies.
Multiple Trophic Tracer Analyses of Subarctic Rhodolith (Lithothamnion glaciale) Bed Trophodynamics Uncover Bottom-Up Forcing and Benthic-Pelagic Coupling
Authors: Hacker Teper Sean , Parrish Christopher C. , Gagnon Patrick 
Published: July 2022

We paired a survey of cryptofaunal abundance and rhodolith morphology with lipid, fatty acid, and stable isotope analyses to quantify nutritional patterns and trophic linkages of six dominant echinoderm, bivalve, gastropod, and polychaete species, two macroalgal species, seawater, and underlying sediment in a large (&gt;500 m2) rhodolith (Lithothamnion glaciale) bed in southeastern Newfoundland (Canada). We found high densities of chitons (Tonicella marmoreaandT. rubra) and daisy brittle star (Ophiopholis aculeata), and overall species composition, rhodolith morphology (shape and size), and total rhodolith biomass were consistent with other studies of the bed, indicating high temporal stability. Our lipid and fatty acid analyses revealed high levels of phospholipids and unsaturated fatty acids combined with low sterols in all animal species, suggesting adaptation for enhanced cell membrane fluidity in a cold-water environment. They also showed that most taxa sampled feed on a shared resource; diatoms, and that (non-kelp) macroalgal detritus are a key food source within rhodolith communities. Our stable isotope analysis uncovered three distinct trophic levels; producers, suspension/filter feeders and grazers, and predators, and unveiled potential resource partitioning between first- (H. arctica) and second- (O. aculeataandTonicellaspp.) order consumers, whereby differences in feeding strategies enable utilization of specific components of the same organic and inorganic material. The unprecedented analytical resolution enabled by the combined use of three trophic tracers indicate that bottom-up forcing (as a mechanism of trophic control) and benthic-pelagic coupling (as a pathway of nutrient and energy flow) operate simultaneously, at least seasonally, in subarctic rhodolith beds.