bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinguishable Prognostic Signatures and Tumor Immunogenicity Between Pancreatic Head Cancer and Pancreatic Body/Tail Cancer
Authors: Ge Weiyu , Ma Jingyu , Mao Tiebo , Xu Haiyan , Zhang Xiaofei , Li Shumin , Wang Yongchao , Yao Jiayu , Yue Ming , Jiao Feng , Wang Yu , Zhuo Meng , Han Ting , Hu Jiong , Zhang Xiao , Cui Jiujie , Wang Liwei 
Published: June 2022

BackgroundPancreatic head cancer and pancreatic body/tail cancer are considered to have different clinical presentations and to have altered outcomes.MethodsNinety cases of pancreatic adenocarcinoma (PDAC) from our institution were used as a discovery set and 166 cases of PDAC from the TCGA cohort were used as a validation set. According to the anatomical location, the cases of PDAC were divided into the pancreatic head cancer group and the pancreatic body/tail cancer group. Firstly, the different biological functions of the two groups were assessed by ssGSEA. Meanwhile, ESTIMATE and CIBERSORT were conducted to estimate immune infiltration. Then, a novel anatomical site-related risk score (SRS) model was constructed by LASSO and Cox regression. Survival and time-dependent ROC analysis was used to prove the predictive ability of our model in two cohorts. Subsequently, an integrated survival decision tree and a scoring nomogram were constructed to improve prognostic stratification and predictive accuracy for individual patients. In addition, gseaGO and gseaKEGG pathway analyses were performed on genes in the key module by the R package.ResultsOverall survival and the objective response rate (ORR) of patients with pancreatic body/tail cancer were markedly superior to those with pancreatic head cancer. In addition, distinct immune characteristics and gene patterns were observed between the two groups. Then, we screened 5 biomarkers related to the prognosis of pancreatic cancer and constructed a more powerful novel SRS model to predict prognosis.ConclusionsOur research shed some light on the revelation of gene patterns, immune and mutational landscape characterizations, and their relationships in different PDAC locations.
Real World Overall Survival of Patients With Metastatic Renal Cell Carcinoma Treated With Only Available Sunitinib and Pazopanib in First-Line Setting
Authors: Nikic Predrag , Babovic Nada , Dzamic Zoran , Salma Svetlana , Stojanovic Vesna , Matkovic Suzana , Pejcic Zoran , Juskic Kristina , Soldatovic Ivan 
Published: June 2022

BackgroundThe emerging new standard of care for metastatic clear cell renal carcinoma (mRCC) becomes a challenge when access to new drugs is limited. In Serbia, sunitinib and pazopanib are the only available first-line therapies. The second-line treatment for mRCC has never been and is still not available. We aimed to assess overall survival (OS) in patients with mRCC who received first-line sunitinib or pazopanib when access to second-line treatment was not available.MethodsThis retrospective observational study analyzed data from a nationally representative cohort of 759 patients who started on first-line sunitinib or pazopanib between 1 January 2012 and 30 June 2019, in 4 centers in Serbia. The data cut-off date was 31 December 2019. Key eligibility criteria were clear cell RCC histology, measurable metastatic disease, performance status 0 or 1, and the Memorial Sloan Kettering Cancer Center favorable or intermediate prognosis. The primary outcome was OS from the start of first-line treatment to death or data cut-off date.ResultsThe study population included 759 patients with mRCC who started with first-line sunitinib (n = 673; [88.7%]) or pazopanib (n = 86; [11.3%]). Overall, the mean age was 61.0 ± 9.7 years at treatment baseline, and 547 (72%) were men. mRCC was primarily diagnosed in 230 (30%) patients, and most of them underwent cytoreductive nephrectomy prior to systemic therapy (n = 181 [79%]). Additional treatment of metastases prior to and/or during treatment was used in 169 patients (22.3%). Grade 3 and 4 adverse events occurred in 168 (22.1%) and 47 patients (6.2%), respectively, and treatment was permanently stopped because of toxicity in 41 (6.9%). The OS was calculated from the start of first-line treatment, and the median follow-up was 14 months (range, 0–97). The median OS in the entire cohort was 17 months (95% CI, 14.6–19.4).ConclusionsWith only available sunitinib and pazopanib in first-line treatment, modest improvements are seen in the overall survival of patients with mRCC in real world clinical practice. In circumstances of limited availability of cancer medicines, our results can contribute to accelerating patient access to novel cancer therapies that have been shown to prolong survival in mRCC.
Multi-Sequence MR-Based Radiomics Signature for Predicting Early Recurrence in Solitary Hepatocellular Carcinoma ≤5 cm
Authors: Wang Leyao , Ma Xiaohong , Feng Bing , Wang Shuang , Liang Meng , Li Dengfeng , Wang Sicong , Zhao Xinming 
Published: June 2022

PurposeTo investigate the value of radiomics features derived from preoperative multi-sequence MR images for predicting early recurrence (ER) in patients with solitary hepatocellular carcinoma (HCC) ≤5 cm.MethodsOne hundred and ninety HCC patients were enrolled and allocated to training and validation sets (n = 133:57). The clinical–radiological model was established by significant clinical risk characteristics and qualitative imaging features. The radiomics model was constructed using the least absolute shrinkage and selection operator (LASSO) logistic regression algorithm in the training set. The combined model was formed by integrating the clinical–radiological risk factors and selected radiomics features. The predictive performance was assessed by the area under the receiver operating characteristic curve (AUC).ResultsArterial peritumoral hyperenhancement, non-smooth tumor margin, satellite nodules, cirrhosis, serosal invasion, and albumin showed a significant correlation with ER. The AUC of the clinical–radiological model was 0.77 (95% CI: 0.69–0.85) and 0.76 (95% CI: 0.64–0.88) in the training and validation sets, respectively. The radiomics model constructed using 12 radiomics features selected by LASSO regression had an AUC of 0.85 (95% CI: 0.79–0.91) and 0.84 (95% CI: 0.73–0.95) in the training and validation sets, respectively. The combined model further improved the prediction performance compared with the clinical–radiological model, increasing AUC to 0.90 (95% CI: 0.85–0.95) in the training set and 0.88 (95% CI: 0.80–0.97) in the validation set (p &lt; 0.001 and p = 0.012, respectively). The calibration curve fits well with the standard curve.ConclusionsThe predictive model incorporated the clinical–radiological risk factors and radiomics features that could adequately predict the individualized ER risk in patients with solitary HCC ≤5 cm.
Impact of Using Unedited CT-Based DIR-Propagated Autocontours on Online ART for Pancreatic SBRT
Authors: Magallon-Baro Alba , Milder Maaike T. W. , Granton Patrick V. , Toom Wilhelm den , Nuyttens Joost J. , Hoogeman Mischa S. 
Published: June 2022

PurposeTo determine the dosimetric impact of using unedited autocontours in daily plan adaptation of patients with locally advanced pancreatic cancer (LAPC) treated with stereotactic body radiotherapy using tumor tracking.Materials and MethodsThe study included 98 daily CT scans of 35 LAPC patients. All scans were manually contoured (MAN), and included the PTV and main organs-at-risk (OAR): stomach, duodenum and bowel. Precision and MIM deformable image registration (DIR) methods followed by contour propagation were used to generate autocontour sets on the daily CT scans. Autocontours remained unedited, and were compared to MAN on the whole organs and at 3, 1 and 0.5 cm from the PTV. Manual and autocontoured OAR were used to generate daily plans using the VOLO™ optimizer, and were compared to non-adapted plans. Resulting planned doses were compared based on PTV coverage and OAR dose-constraints.ResultsOverall, both algorithms reported a high agreement between unclipped MAN and autocontours, but showed worse results when being evaluated on the clipped structures at 1 cm and 0.5 cm from the PTV. Replanning with unedited autocontours resulted in better OAR sparing than non-adapted plans for 95% and 84% plans optimized using Precision and MIM autocontours, respectively, and obeyed OAR constraints in 64% and 56% of replans.ConclusionFor the majority of fractions, manual correction of autocontours could be avoided or be limited to the region closest to the PTV. This practice could further reduce the overall timings of adaptive radiotherapy workflows for patients with LAPC.
Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis
Authors: Chattopadhyay Kaushik , Wang Haiquan , Kaur Jaspreet , Nalbant Gamze , Almaqhawi Abdullah , Kundakci Burak , Panniyammakal Jeemon , Heinrich Michael , Lewis Sarah Anne , Greenfield Sheila Margaret , Tandon Nikhil , Biswas Tuhin Kanti , Kinra Sanjay , Leonardi-Bee Jo 
Published: June 2022

Introduction:Many Ayurvedic medicines have the potential for managing type 2 diabetes mellitus (T2DM), with previous systematic reviews demonstrating effectiveness and safety for specific Ayurvedic medicines. However, many of the reviews need updating and none provide a comprehensive summary of all the Ayurvedic medicines evaluated for managing T2DM.Objective:The objective of this systematic review was to evaluate and synthesize evidence on the effectiveness and safety of Ayurvedic medicines for managing T2DM.Inclusion criteria:Published and unpublished RCTs assessing the effectiveness and safety of Ayurvedic medicines for managing T2DM in adults.Methods:The JBI systematic review methodology was followed. A comprehensive search of sources (including 18 electronic databases) from inception to 16 January 2021 was made. No language restrictions were applied. Data synthesis was conducted using narrative synthesis and random effects meta-analyses, where appropriate. Pooled results are reported as mean differences (MD) with 95% confidence intervals (CI).Results:Out of 32,519 records identified from the searches, 219 articles were included in the systematic review representing 199 RCTs (21,191 participants) of 98 Ayurvedic medicines. Overall, in the studies reviewed the methodology was not adequately reported, resulting in poorer methodological quality scoring. Glycated hemoglobin (HbA1c) was reduced usingAegle marmelos(L.) Corrêa (MD -1.6%; 95% CI −3 to −0.3),Boswellia serrataRoxb. (−0.5; −0.7 to −0.4),Gynostemma pentaphyllum(Thunb.) Makino (−1; −1.5 to −0.6),Momordica charantiaL. (−0.3; −0.4 to −0.1),Nigella sativaL. (−0.4; −0.6 to −0.1),Plantago ovataForssk. (−0.9; −1.4 to −0.3),Tinospora cordifolia(Willd.) Hook.f. and Thomson (−0.5; −0.6 to −0.5),Trigonella foenum-graecumL. (−0.6; −0.9 to −0.4), andUrtica dioicaL. (−1.3; −2.4 to −0.2) compared to control. Similarly, fasting blood glucose (FBG) was reduced by 4–56 mg/dl for a range of Ayurvedic medicines. Very few studies assessed health-related quality of life (HRQoL). Adverse events were not reported in many studies, and if reported, these were mostly none to mild and predominately related to the gastrointestinal tract.Conclusion:The current evidence suggests the benefit of a range of Ayurvedic medicines in improving glycemic control in T2DM patients. Given the limitations of the available evidence and to strengthen the evidence base, high-quality RCTs should be conducted and reported.
Post-Marketing Safety Concerns With Secukinumab: A Disproportionality Analysis of the FDA Adverse Event Reporting System
Authors: Shu Yamin , Ding Yufeng , Liu Yanxin , Wu Pan , He Xucheng , Zhang Qilin 
Published: June 2022

Purpose: Secukinumab was approved for the treatment of psoriasis, psoriatic arthritis, and ankylosing spondylitis. However, the long-term safety of secukinumab in large sample population was unknown. The current study was to evaluate the secukinumab-assocaited adverse events (AEs) through data mining of the US Food and Drug Administration Adverse Event Reporting System (FAERS).Methods: Reports in the FAERS from the first quarter of 2015 (FDA approval of secukinumab) to the third quarter of 2021 were collected and analyzed. Disproportionality analyses, including the reporting odds ratio (ROR), the proportional reporting ratio (PRR), the Bayesian confidence propagation neural network (BCPNN), and the multi-item gamma Poisson shrinker (MGPS) algorithms, were employed in data mining to quantify the signals of secukinumab-related AEs.Results: A total of 89,228 reports of secukinumab as the “primary suspected (PS)” and 254,886 AEs induced by secukinumab were identified. Secukinumab-induced AE occurrence targeted 27 system organ classes (SOCs). A total of 257 signals of secukinumab-induced AEs in 19 SOCs were detected after conforming to the four algorithms simultaneously. Common significant signals of infections, respiratory disorders, skin and subcutaneous tissue disorders, immune system disorders, and ear and labyrinth disorders have emerged. Unexpected significant AEs such as injection site pain, vessel puncture site haemorrhage, arthralgia, hypokinesia, Bell’s palsy, parotid gland enlargement, and stress might also occur. The median onset time of secukinumab-associated AEs was 56 days (interquartile range [IQR] 5–214 days), and most of the onsets occurred within the first 1, 2, 3, and 4 months after initiation of secukinumab.Conclusion: Our study found potential new AE signals and provided a broader understanding of secukinumab’s safety profiles, supporting its rational use in chronic systemic inflammatory diseases.
The Effects of Vagus Nerve Stimulation on Ventricular Electrophysiology and Nitric Oxide Release in the Rabbit Heart
Authors: Allen Emily , Pongpaopattanakul Pott , Chauhan Reshma A. , Brack Kieran E. , Ng G. André 
Published: June 2022

Background: Abnormal autonomic activity including impaired parasympathetic control is a known hallmark of heart failure (HF). Vagus nerve stimulation (VNS) has been shown to reduce the susceptibility of the heart to ventricular fibrillation, however the precise underlying mechanisms are not well understood and the detailed stimulation parameters needed to improve patient outcomes clinically are currently inconclusive.Objective: To investigate NO release and cardiac electrophysiological effects of electrical stimulation of the vagus nerve at varying parameters using the isolated innervated rabbit heart preparation.Methods: The right cervical vagus nerve was electrically stimulated in the innervated isolated rabbit heart preparation (n = 30). Heart rate (HR), effective refractory period (ERP), ventricular fibrillation threshold (VFT) and electrical restitution were measured as well as NO release from the left ventricle.Results: High voltage with low frequency VNS resulted in the most significant reduction in HR (by −20.6 ± 3.3%, −25.7 ± 3.0% and −30.5 ± 3.0% at 0.1, 1 and 2 ms pulse widths, with minimal increase in NO release. Low voltage and high frequency VNS significantly altered NO release in the left ventricle, whilst significantly flattening the slope of restitution and significantly increasing VFT. HR changes however using low voltage, high frequency VNS were minimal at 20Hz (to 138.5 ± 7.7 bpm (−7.3 ± 2.0%) at 1 ms pulse width and 141.1 ± 6.6 bpm (−4.4 ± 1.1%) at 2 ms pulse width).Conclusion: The protective effects of the VNS are independent of HR reductions demonstrating the likelihood of such effects being as a result of the modulation of more than one molecular pathway. Altering the parameters of VNS impacts neural fibre recruitment in the ventricle; influencing changes in ventricular electrophysiology, the protective effect of VNS against VF and the release of NO from the left ventricle.
A Scientometric Analysis and Visualization Discovery of Enhanced Recovery After Surgery
Authors: Zhang Mingjie , Wang Xiaoxue , Chen Xueting , Song Zixuan , Wang Yuting , Zhou Yangzi , Zhang Dandan 
Published: June 2022

BackgroundEnhanced recovery after surgery (ERAS), a new clinical surgical concept, has been applied in many surgical disciplines with good clinical results for the past 20 years. Bibliometric analysis is an effective method to quantitatively evaluate the academic productivity. This report aimed to perform a scientometric analysis of the ERAS research status and research hotspots.MethodsComprehensive scientific mapping analysis of a wide range of literature metadata using the scientometric tools, including the Bibliometrix R Package, Biblioshiny, and CiteSpace. Data were retrieved from the Web of Science Core Collection database of original articles from 2001 to 2020. Specific indicators and maps were analyzed to show the co-authorship, co-institute, co-country, co-citation, and international cooperation. Automatic literature screening, unsupervised cluster filtering, and topic cluster identification methods were used to display the conceptual framework and thematic evolution.ResultsA total of 1,403 research projects drafted by 6,966 authors and published in 413 sources were found. There was an exponential growth in the number of publications on ERAS. There were 709 collaborations between authors from different countries, and the US, China, and the UK had the greatest number of publications. The WORLD JOURNAL OF SURGERY, located in Bradford’s Law 1, had the highest number of published articles (n = 1,276; total citations = 3,193). CiteSpace network analysis revealed 15 highly correlated cluster ERAS studies, and the earliest study was on colonic surgery, and ERAS was recently applied in cardiac surgery. The etiology of ERAS is constantly evolving, with surgery and length of hospital as the main topics. Meta-analyses and perioperative care have tended to decline.ConclusionThis is the first scientometric analysis of ERAS to provide descriptive quantitative indicators. This can provide a better understanding of how the field has evolved over the past 20 years, help identify research trends, and provide insights and research directions for academic researchers, policymakers, and medical practitioners who want to collaborate in these areas in the future.
Non-Surgical treatment Versus Surgery for Iatrogenic Femoral Artery Pseudoaneurysms: Systematic Review and Meta-Analysis
Authors: Wu Haoliang , Zhang Liwei , Zhang Cong , Xie Boao , Lou Chunyang , Liu Yuanfeng , Bai Hualong 
Published: June 2022

ObjectivesThis study compared results of non-surgical treatment (compression and ultrasound guided thrombin injection (UGTI)) and surgery to treat iatrogenic femoral artery pseudoaneurysms.MethodsPubMed and Embase databases were searched up to October 2021. Primary outcome measure was success rate, and other outcomes examined were complication rate, reintervention rate. Two authors independently reviewed and extracted data. Data were presented as the odds ratios (ORs) with 95% confidence intervals (CIs). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to appraise the quality of the body of evidence.ResultsEight studies were included. A total of 623 patients with pseudoaneurysm undergoing treatment were included, of which 163 subjects underwent surgery, 397 subjects underwent compression, and 63 subjects underwent UGTI. The success rate was significantly lower in the non-surgery group (OR 0.24, 95% CI, 0.08–0.69, I2 = 0%). The complication rate was significantly lower in the non-surgery group (OR 0.10, 95% CI, 0.03 –0.29, I2 = 0%). Patients in the non-surgery group tended to have a lower, but statistically insignificant, reintervention rate (OR 0.11, 95% CI, 0.01–1.06, I2 = 35%). Further, the GRADE assessment showed that these results (success rate, complication rate, and reintervention rate) were of very low quality.ConclusionsAvailable evidence shows that it is reasonable to regard non-surgical treatment as the primary treatment for iatrogenic femoral artery pseudoaneurysms, and surgery as a remedy after failure of non-surgical treatment in some cases.
THE “FLIPPED CLASSROOM” MODEL: WHAT IT IS AND HOW IT WORKS
Authors: Gron Larysa , Antonenko Nataliia 
Published: June 2022

The desire to learn ESL/EFL has skyrocketed worldwide due to technology development and blended learning. This constant demand forces teachers to develop new and functional approaches and methods to improve ESL/EFL teaching and learning processes, and one of these methods is blended learning. According to King (2016), "blended learning" is defined in many ways. However, all definitions have two things in common: asynchronous (online) and synchronous (face-to-face), which means that blended learning combines face-to-face and online instruction elements to assist teachers and students in the teaching process and education.
The modern standard of higher education reflects the need to form and improve foreign language communicative competence necessary for successful socialization as a tool for intercultural communication in the modern multicultural world. It becomes the starting point for pedagogical design, as the learning process requires completely new tools and methods. This article is devoted to description of the main principles of “flipped classroom” model in the process of teaching a foreign language.
The method's advantages manifest in the release of lesson time for performing creative tasks and including students in the active learning activity. The article describes the advantages and disadvantages of the "flipped classroom," the difficulties that arise in its implementation, and the positive effect that can be achieved by using this method in foreign language classes at the university.
ПЕДАГОГІЧНІ УМОВИ ПРОФЕСІЙНОЇ ПІДГОТОВКИ ПЕДАГОГІВ ДО ВИКОРИСТАННЯ ІННОВАЦІЙНИХ ТЕХНОЛОГІЙ
Authors: Потапчук Тетяна 
Published: June 2022

У статті зазначено, що ефективність роботи освітніх закладів залежить не лише від програм навчання і виховання, а й від особистості педагога, його взаємин з дітьми. Сучасний педагог – це професіонал, який орієнтується в наукових досягненнях, в інноваціях, володіє різними технологіями розвитку, навчання і виховання дітей, здатний до саморозвитку, самовдосконалення, самомоделювання та самопроектування в різних сферах життєдіяльності, в точу числі й у професійній. У зв’язку з цим особлива увага звертається на істотне підвищення якості професійної підготовки педагогів. Теоретично обгрунтовано педагогічні умови професійної підготовки педагогів до використання інноваційних технологій, серед яких: формування у педагогів позитивної професійно-орієнтованої мотивації до оволодіння інноваційними технологіями з метою їх ефективного застосування у майбутній професійній діяльності; варіативне використання традиційних та інноваційних форм і методів фахової підготовки педагогів до опанування інноваційними технологіями в процесі вивчення нормативних і спеціальних курсів; інтеграція теоретичної та практичної підготовки фахівців до використання інноваційних технологій. Визначені нами взаємопов’язані педагогічні умови покликані забезпечити якісну організацію процесу формування готовності педагогів до застосування інноваційних технологій у роботі з дітьми.