bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dust distributions in the magellanic clouds
Authors: Chen B-Q , Guo H-L , Gao J , Yang M , Liu Y-L , Jiang B-W 
Published: January 2022

ABSTRACT
We present high-resolution maps of the dust reddening in the Magellanic Clouds (MCs). The maps cover the Large and Small Magellanic Cloud (LMC and SMC) area and have a spatial angular resolution between ∼26 arcsec and 55 arcmin. Based on the data from the optical and near-infrared (IR) photometric surveys, including the Gaia Survey, the SkyMapper Southern Survey (SMSS), the Survey of the Magellanic Stellar History (SMASH), the Two Micron All Sky Survey (2MASS), and the near-IR YJKS VISTA survey of the Magellanic Clouds system (VMC), we have obtained multiband photometric stellar samples containing over 6 million stars in the LMC and SMC area. Based on the measurements of the proper motions and parallaxes of the individual stars from Gaia Early Data Release 3 (Gaia EDR3), we have built clean samples that contain stars from the LMC, SMC, and Milky Way (MW), respectively. We apply the spectral energy distribution (SED) fitting to the individual sample stars to estimate their reddening values. As a result, we have derived the best-fitting reddening values of ∼1.9 million stars in the LMC, 1.5 million stars in the SMC, and 0.6 million stars in the MW, which are used to construct dust reddening maps in the MCs. Our maps are consistent with those from the literature. The resultant high-resolution dust maps in the MCs are not only important tools for reddening correction of sources in the MCs, but also fundamental for the studies of the distribution and properties of dust in the two galaxies.
Faint intermediate luminosity optical transients (ILOTs) from engulfing exoplanets on the Hertzsprung gap
Authors: Gurevich Omer , Bear Ealeal , Soker Noam 
Published: January 2022

ABSTRACT
We follow the evolution of four observed exoplanets to the time when the respective parent star of each planet evolves off the main sequence and engulfs its planet to start a common envelope evolution (CEE), concluding that in each case this process powers an intermediate luminosity optical transient (ILOT; luminous red nova). We characterize the final thousands of days of the orbital decay towards a CEE and determine the properties of the star at the onset of the CEE. We scale the properties of the ILOT V1309 Scorpii to the properties of a planet that enters a CEE inside a star on and near the Hertzsprung gap to estimate the duration and luminosity of the expected ILOT. Based on these, we estimate that for a planet of Jupiter mass the ILOT will last for several days and reach a luminosity of several thousand solar luminosity. This type of ILOTs are less luminous than classical novae. Because of the small amount of expected dust and the small amount of energy that an accretion process on to the planet can release, such ILOTs can teach us on the merger at the onset of CEE of stellar companions. Our study adds to the variety of ILOTs that planets can power as they interact with a more massive companion.
Role of the companion lensing galaxy in the CLASS gravitational lens B1152+199
Authors: Zhang M , Yuan Q , Liu J-Y , Zhang L 
Published: January 2022

ABSTRACT
We reinvestigate the Cosmic Lens All-Sky Survey (CLASS) gravitational lens B1152+199 using archived Hubble Space Telescope (HST) data and Very Long Baseline Interferometry (VLBI) data. A consistent luminosity ratio within effective radius between the host galaxy and the X-galaxy is measured from HST tri-band images, which leads to a mass ratio between the two galaxies as rb ∼ 2. To determine the role of the X-galaxy in the lens system, we modelled the dual-lens system with constraints from the VLBI-resolved jet components and the HST images. The 8.4-GHz global-VLBI data currently provide the most stringent constraints to the mass model, especially to the radial power-law slope. The optimized models for this two-image three-component radio lens favour a steeper-than-isothermal inner slope. The jet bending in image B was also investigated and it turned out to be rather a misalignment than a curvature. The goodness-of-fit indicates that the role of the X-galaxy is crucial in the lens system if three pairs of resolved jet components are to be fitted. When we imported the optimal model from radio constraints to optical modelling with the HST tri-band data, the optimization kept the consistency of the optimal model and successfully reproduced the features observed in the HST images. This implies that the diffuse emission discovered in the HST images is actually a detection of the secondary lensing effects from the companion lens.
The Multiple-Computations Theorem and the Physics of Singling Out a Computation
Authors: Hemmo Meir , Shenker Orly 
Published: January 2022

AbstractThe problem of multiple-computations discovered by Hilary Putnam presents a deep difficulty for functionalism (of all sorts, computational and causal). We describe in outline why Putnam’s result, and likewise the more restricted result we call the Multiple-Computations Theorem, are in fact theorems of statistical mechanics. We show why the mere interaction of a computing system with its environment cannot single out a computation as the preferred one amongst the many computations implemented by the system. We explain why nonreductive approaches to solving the multiple-computations problem, and in particular why computational externalism, are dualistic in the sense that they imply that nonphysical facts in the environment of a computing system single out the computation. We discuss certain attempts to dissolve Putnam’s unrestricted result by appealing to systems with certain kinds of input and output states as a special case of computational externalism, and show why this approach is not workable without collapsing to behaviorism. We conclude with some remarks about the nonphysical nature of mainstream approaches to both statistical mechanics and the quantum theory of measurement with respect to the singling out of partitions and observables.
TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination
Authors: Zhu Xuefei , Xue Jingwei , Jiang Xing , Gong Yamin , Gao Congwen , Cao Ting , Li Qian , Bai Lulu , Li Yuwei , Xu Gaixia , Peng Bin , Xu Xingzhi 
Published: January 2022

Abstract
Expression of the E3 ligase TRIM21 is increased in a broad spectrum of cancers; however, the functionally relevant molecular pathway targeted by TRIM21 overexpression remains largely unknown. Here, we show that TRIM21 directly interacts with and ubiquitinates CLASPIN, a mediator for ATR-dependent CHK1 activation. TRIM21-mediated K63-linked ubiquitination of CLASPIN counteracts the K6-linked ubiquitination of CLASPIN which is essential for its interaction with TIPIN and subsequent chromatin loading. We further show that overexpression of TRIM21, but not a TRIM21 catalytically inactive mutant, compromises CHK1 activation, leading to replication fork instability and tumorigenesis. Our findings demonstrate that TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination, providing a potential target for cancer therapy.
Evaluation of Liver and Renal Toxicity in Peptide Receptor Radionuclide Therapy for Somatostatin Receptor Expressing Tumors: A 2-Year Follow-Up
Authors: Duan Heying , Ferri Valentina , Fisher George Albert , Shaheen Shagufta , Davidzon Guido Alejandro , Iagaru Andrei , Mari Aparici Carina 
Published: January 2022

AbstractBackgroundPeptide receptor radionuclide therapy (PRRT) with radiolabeled somatostatin receptor (SSR) analogs is now an established systemic treatment for neuroendocrine tumors (NET). However, more short- and long-term data about renal and hepatotoxicity is needed. Here we present our experience in this clinical scenario.MethodsEighty-six patients with progressive SSR-expressing malignancies underwent PRRT with Lu-177 Dotatate and were followed up for up to 2 years. Laboratory tests were done 1 week before each cycle and every 2 months at follow-up. Hepatic and renal toxicity was determined based on NCI CTCAE V5.0.Results55/86 (64%) patients completed all 4 cycles of PRRT; 18/86 (20.9%) are currently being treated; 13/86 (15.1%) had to discontinue PRRT: 4/13 (31%) due to hematologic toxicity, 9/13 (69%) due to non-PRRT-related comorbidities. Out of the patients who finished treatment, only transient grade 2 toxicities were observed during PRRT: hypoalbuminemia in 5.5% (3/55), and renal toxicity (serum creatinine and estimated glomerular filtration rate) in 1.8% (1/55). No grade 3 or 4 liver and renal toxicity occurred. Patients presenting with impaired liver or renal function prior to PRRT, either improved or had stable findings. No deterioration was observed.ConclusionPeptide receptor radionuclide therapy does not have a negative impact on liver and renal function, even in patients with pre-existing impaired parameters. No grade 3 or 4 hepatic or renal toxicity was identified. Only transient grade 2 hypoalbuminemia in 5.5% and nephrotoxicity in 1.8% of patients were seen during PRRT.
Modeling the Cost-Effectiveness of Adjuvant Osimertinib for Patients with Resected EGFR-mutant Non-Small Cell Lung Cancer
Authors: Lemmon Christopher A , Zabor Emily C , Pennell Nathan A 
Published: January 2022

Abstract

Introduction
The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor osimertinib was recently approved for resected EGFR-mutant stages IB-IIIA non-small cell lung cancer due to improved disease-free survival (DFS) in this population compared with placebo. This study aimed to evaluate the cost-effectiveness (CE) of this strategy.

Materials and Methods
We constructed a Markov model using post-resection health state transitions with digitized DFS data from the ADAURA trial to compare cost and quality-adjusted life years (QALYs) of 3 years of adjuvant osimertinib versus placebo over a 10-year time horizon. An overall survival (OS) benefit of 5% was assumed. Costs and utility values were derived from Medicare reimbursement data and literature. A CE threshold of 3 times the gross domestic product per capita was used. Sensitivity analyses were performed.

Results
The incremental cost-effectiveness ratio for adjuvant osimertinib was $317 119 per QALY-gained versus placebo. Initial costs of osimertinib are higher in years 1-3. Costs due to progressive disease (PD) are higher in the placebo group through the first 6.5 years. Average pre-PD, post-PD, and total costs were $2388, $379 047, and $502 937, respectively, in the placebo group, and $505 775, $255 638, and $800 697, respectively, in the osimertinib group. Sensitivity analysis of OS gains reaches CE with an hazard ratio (HR) of 0.70-0.75 benefit of osimertinib over placebo. A 50% discount to osimertinib drug cost yielded an ICER of $115 419.

Conclusions
Three-years of adjuvant osimertinib is CE if one is willing to pay $317 119 more per QALY-gained. Considerable OS benefit over placebo or other economic interventions will be needed to reach CE.
Isotemporal Substitution of Sedentary Behavior With Moderate to Vigorous Physical Activity Is Associated With Lower Risk of Disability: A Prospective Longitudinal Cohort Study
Authors: Chiba Ippei , Lee Sangyoon , Bae Seongryu , Makino Keitaro , Shinkai Yohei , Katayama Osamu , Harada Kenji , Yamashiro Yukari , Takayanagi Naoto , Shimada Hiroyuki 
Published: January 2022

Abstract

Objective
The purpose of the study was to estimate, using an isotemporal substitution model, the effect of replacing sedentary behavior (SB) with physical activity on the incidence of disability in community-dwelling older adults.

Methods
This 2-year longitudinal cohort study enrolled 3691 community-dwelling older adults (57.2% women; mean age = 74.0 [SD = 5.0] years). Individuals with dementia, stroke, Parkinson disease, depression, low Mini-Mental State Examination scores, dependence on basic activities of daily living, and missing data were excluded. Physical activity and potential confounding factors were investigated as a baseline survey of disability incidence, defined by Japanese long-term care insurance certification, for 2 years in 2 regions. Physical activity data (SB, light-intensity physical activity, and moderate- to vigorous-intensity physical activity [MVPA]) were measured using triaxial accelerometers for 14 days, and daily mean time spent in each physical activity parameter was computed in increments of 10 minutes. The relationship between baseline physical activity and disability incidence adjusted for potential confounders was analyzed using multilevel Cox proportional hazards regression analyses with an isotemporal substitution model.

Results
The disability incidence rate was 3.8%, excluding individuals who could not be followed-up. Replacing 10 minutes of SB per day with MVPA was associated with a decreased disability incidence (hazard ratio = 0.870; 95% CI = 0.766–0.988), whereas no evidence was found for replacing SB with light-intensity physical activity (hazard ratio = 0.980; 95% CI = 0.873–1.10).

Conclusions
Replacing SB with MVPA was associated with a lower risk of disability. These findings are helpful for establishing disability prevention strategies.

Impact
These results suggest that feasible changes in daily behavior, such as replacing 10 minutes of SB with MVPA daily, might have a protective effect on disability incidence. Clarifying these associations is useful for developing disability prevention strategies and may help reduce the incidence of disability in community-dwelling older adults.
Rapid antigen testing in COVID-19 management for school-aged children: an observational study in Cheshire and Merseyside, UK
Authors: Hughes David M , Bird Sheila M , Cheyne Christopher P , Ashton Matthew , Campbell Melisa C , García-Fiñana Marta , Buchan Iain 
Published: January 2022

AbstractBackgroundTwice weekly lateral flow tests (LFTs) for secondary school children was UK Government policy from 8 March 2021. We evaluate use of LFTs (both supervised at test centres, and home test kits) in school-aged children in Cheshire and Merseyside.MethodsWe report (i) number of LFT positives (ii) proportion of LFT positive with confirmatory reverse transcription polymerase chain reaction (PCR) test within 2 days, and (iii) agreement between LFT-positive and confirmatory PCR, and dependence of (i–iii) on COVID-19 prevalence.Findings1 248 468 LFTs were taken by 211 255 12–18 years old, and 163 914 by 52 116 5–11 years old between 6 November 2020 and 31 July 2021. Five thousand three hundred and fourteen (2.5%) 12–18 years old and 1996 (3.8%) 5–11 years old returned LFT positives, with 3829 (72.1%) and 1535 (76.9%) confirmatory PCRs, and 3357 (87.7%) and 1383 (90.1%) confirmatory PCR-positives, respectively.Monthly proportions of LFT positive with PCR negative varied between 4.7% and 35.3% in 12–18 years old (corresponding proportion of all tests positive: 9.7% and 0.3%).Deprivation and non-White ethnicity were associated with reduced uptake of confirmatory PCR.InterpretationSubstantial inequalities in confirmatory testing need more attention to avoid further disadvantage through education loss. When prevalence is low additional measures, including confirmatory testing, are needed. Local Directors of Public Health taking more control over schools testing may be needed.FundingDHSC, MRC, NIHR, EPSRC.
A Runx1-enhancer Element eR1 Identified Lineage Restricted Mammary Luminal Stem Cells
Authors: Matsuo Junichi , Mon Naing Naing , Douchi Daisuke , Yamamura Akihiro , Kulkarni Madhura , Heng Dede Liana , Chen Sabirah , Nuttonmanit Napat , Li Ying , Yang Henry , Lee May Yin , Tam Wai Leong , Osato Motomi , Chuang Linda Shyue Huey , Ito Yoshiaki 
Published: January 2022

Abstract
Mammary gland homeostasis is maintained by adult tissue stem-progenitor cells residing within the luminal and basal epithelia. Dysregulation of mammary stem cells is a key mechanism for cancer development. However, stem cell characterization is challenging because reporter models using cell-specific promoters do not fully recapitulate the mammary stem cell populations. We previously found that a 270-basepair Runx1 enhancer element, named eR1, marked stem cells in the blood and stomach. Here, we identified eR1 activity in a rare subpopulation of the ERα-negative luminal epithelium in mouse mammary glands. Lineage-tracing using an eR1-CreERT2 mouse model revealed that eR1+ luminal cells generated the entire luminal lineage and milk-secreting alveoli—eR1 therefore specifically marks lineage-restricted luminal stem cells. eR1-targeted-conditional knockout of Runx1 led to the expansion of luminal epithelial cells, accompanied by elevated ERα expression. Our findings demonstrate a definitive role for Runx1 in the regulation of the eR1-positive luminal stem cell proliferation during mammary homeostasis. Our findings identify a mechanistic link for Runx1 in stem cell proliferation and its dysregulation in breast cancer. Runx1 inactivation is therefore likely to be an early hit in the cell-of-origin of ERα+ luminal type breast cancer.
Effects of a dry acidulant addition to prevent Salmonella contamination in poultry feed
Authors: Jeffrey Andrea M , Aldrich Greg C , Huss Anne R , Knueven Carl , Jones Cassandra K , Zumbaugh Charles A 
Published: January 2022

Abstract
Salmonella subs. serovar Enteritidis is a potential biological pathogen of concern in the poultry industry. Contamination of the bacterium on eggshells has led to human illnesses. With the implementation of new regulations, animal feed manufacturing continues to be under more stringent requirements. Specifically, there is zero tolerance for Salmonella Pullorum, Gallinarum, or Enteritidis in poultry feed. For this reason, it is important to determine an effective method of reducing or preventing Salmonella contamination in feed for poultry. Therefore, the objective of this study was to evaluate the impact of sodium bisulfate (SBS; Jones-Hamilton, Co., Walbridge, OH) added to poultry mash to reduce or prevent Salmonella growth over time. A single, commercially produced all-flock poultry mash was mixed with four different levels of SBS: 0.0%, 0.25%, 0.50%, and 0.70%. After SBS addition, the treated mash was inoculated with Salmonella enterica subsp, enterica serovar Enteritidis (ATCC 13076) and enumerated for Salmonella on days 0, 1, 2, 7, and 14 post-inoculation by plating on xylose lysine deoxycholate agar. There was no significant effect of SBS inclusion level on the reduction of Salmonella (P = 0.23); however, there was a significant effect of time across treatments (P &lt; 0.0001). Additionally, there was no inclusion level × time interaction (P = 0.68). These results suggest that while SBS inclusion has no effect on Salmonella concentrations, storage time is effective at reducing or eliminating Salmonella contamination in poultry feed.
Overview of common practices in calf raising facilities
Authors: Machado Vinicius S , Ballou Michael A 
Published: January 2022

Abstract
In this literature review, we overview some of the common management practices associated with calf rearing in specialized operations of the United States. Given the growing importance of dairy-beef calves entering the beef production of the United States, we overview aspects related to housing, nutrition, and health events during the pre- and post-weaning period. Based on data on dairy animals, we hypothesize how early life experiences could impact the feedlot performances of dairy-beef animals. Most of the large calf raising operations, where the majority of dairy-beef animals are raised, are located in the Central Great Plains and West regions of the United States. Approximately 80% of calves are individually housed, but the type of housing (e.g., outside hutch, inside a barn) varies based on location of calf-raising facilities. Milk-replacer is fed in more than 80% of operations, while milk (saleable or nonsaleable) is fed in approximately 30% of calf raising facilities (some operations fed more than one type of liquid diet). In addition to liquid feed, water and calf starter are offered ad libitum to calves. Adequate starter intake at weaning is crucial for feed transition from pre- to post-weaning period, which occurs at approximately 2 months of age. Then, calves are mainly housed in group pens and transition from calf-starter to total mixed ration (TMR). Health challenges such as scours and bovine respiratory disease (BRD) can hinder the performance of calves and are major causes of morbidity and mortality in calf ranches. Transportation at a very young age and comingling with animals from other dairies can increase the risk of diseases. Current research efforts are focusing on determining individual factors such as body weight (BW) at arrival or biomarkers of inflammation and stress that can be predictive of disease morbidity, mortality, and performance of calves. Future research should focus on how to utilize this information to optimize management and to develop targeted preventative strategies to reduce incidence of diseases and mortality and improve performance during the pre-weaned period. Also, more research is needed to understand how colostrum management, housing, and nutrition can impact the adult performance of dairy-beef animals.
DNA Damage and Repair and Epigenetic Modification in the Role of Oxoguanine Glycosylase 1 in Brain Development
Authors: Bhatia Shama , Arslan Eliyas , Rodriguez-Hernandez Luis David , Bonin Robert , Wells Peter G 
Published: January 2022

AbstractOxoguanine glycosylase 1 (OGG1) repairs the predominant reactive oxygen species-initiated DNA lesion 8-oxoguanine. Human OGG1 polymorphisms resulting in reduced DNA repair associate with an increased risk for disorders like cancer and diabetes, but the role of OGG1 in brain development is unclear. Herein, we show that Ogg1 knockout mice at 2–3 months of age exhibit enhanced gene- and sex-dependent DNA damage (strand breaks) and decreased epigenetic DNA methylation marks (5-methylcytosine, 5-hydroxymethylcytosine), both of which were associated with increased cerebellar calbindin levels, reduced hippocampal postsynaptic function, altered body weight with age and disorders of brain function reflected in behavioral tests for goal-directed repetitive behavior, anxiety and fear, object recognition and spatial memory, motor coordination and startle response. These results suggest that OGG1 plays an important role in normal brain development, possibly via both its DNA repair activity and its role as an epigenetic modifier, with OGG1 deficiencies potentially contributing to neurodevelopmental disorders.
Diagnostic, predictive and prognostic biomarkers in systemic lupus erythematosus: current insights
Authors: Lindblom Julius , Mohan Chandra , Parodis Ioannis 
Published: January 2022

Purpose of review
Biomarkers for diagnosis, monitoring and prognosis still constitute an unmet need for systemic lupus erythematosus (SLE). Focusing on recent findings, this review summarises the current landscape of biomarkers in lupus.

Recent findings
Urine activated leukocyte cell adhesion molecule (ALCAM) exhibited good diagnostic ability in SLE and lupus nephritis (LN) whereas cerebrospinal fluid neutrophil gelatinase-associated lipocalin (NGAL) showed promise in neuropsychiatric SLE. Urine ALCAM, CD163 and vascular cell adhesion molecule 1 (VCAM-1) may be useful in surveillance of LN. Urine monocyte chemoattractant protein 1 was found to predict treatment response in SLE, and urine CD163 and NGAL treatment response in LN. Serum complement component 3 (C3) and urinary VCAM-1 have been reported to portend long-term renal prognosis in LN.

Summary
NGAL holds promise as a versatile biomarker in SLE whereas urine ALCAM, CD163 and VCAM-1 displayed good performance as biomarkers in LN. The overall lack of concerted corroboration of leading candidates across multiple cohorts and diverse populations leaves the current biomarker landscape in SLE in an urgent need for further survey and systematic validation.