bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fetal muscle extract improves muscle function and performance in aged mice
Authors: Jessica Lo Hiu Tung , Yiu Tsz Lam , Wang Yujia , Feng Lu , Li Gang , Lui May Pui-Man , Lee Wayne Yuk-Wai 
Published: October 2022

Background: Loss of skeletal muscle mass and function is one of the major musculoskeletal health problems in the aging population. Recent studies have demonstrated differential proteomic profiles at different fetal stages, which might be associated with muscle growth and development. We hypothesized that extract derived from fetal muscle tissues at the stage of hypertrophy could ameliorate the loss of muscle mass and strength in aged mice.Methods: To allow sufficient raw materials for investigation, skeletal muscle extract from fetal sheep at week 16 of gestation and maternal tissue were used in the present study. iTRAQ (isobaric tags for relative and absolute quantitation) and KEGG pathway analyses identified differentially expressed proteins in fetal sheep muscle extract vs. adult sheep muscle extract. Effects of FSME and ASME on human myoblast proliferation were studied. To examine the effect of FSME in vivo, C57BL/6 male mice at 20 months of age were subjected to intramuscular administration of FSME or vehicle control for 8 weeks. A grip strength test and ex vivo muscle force frequency test were conducted. Finally, serum samples were collected for multiplex analysis to determine potential changes in immunological cytokines upon FSME injection.Results: Compared with ASME, 697 and 412 peptides were upregulated and downregulated, respectively, in FSME, as indicated by iTRAQ analysis. These peptides were highly related to muscle development, function, and differentiation from GO enrichment analysis. FSME promoted cell proliferation of myoblast cells (+300%, p &lt; 0.01) without causing significant cytotoxicity at the tested concentration range compared with ASME. After 8 weeks of FSME treatment, the percentage of lean mass (+10%, p &lt; 0.05), grip strength (+50%, p &lt; 0.01), and ability in fatigue resistance were significantly higher than those of the control group. Isometric forces stimulated by different frequencies were higher in the control group. Histologically, the control group showed a larger cross-sectional area (+20%, p &lt; 0.01) than the FSME group. The multiplex assay indicated that FSME treatment did not lead to an elevated circulatory level of inflammatory cytokines. Of note, after FSME treatment, we observed a significant drop in the circulating level of IL-12 (p40) from 90.8 ± 48.3 pg/ml to 82.65 ± 4.4 pg/ml, G-CSF from 23476 ± 8341.9 pg/ml to 28.35 ± 24.2 pg/ml, KC from 97.09 ± 21.2 pg/ml to 29.2 ± 7.2 pg/ml, and RANTES from 325.4 ± 17.3 pg/ml to 49.96 ± 32.1 pg/ml.Conclusion: This is the first study demonstrating the beneficial effect of fetal muscle extract on muscle health in aged mice. Further analysis of the active ingredients of the extract will shed light on the development of a novel treatment for sarcopenia.
Cost-effectiveness analysis of a community-based colorectal cancer screening program in Shanghai, China
Authors: Jiang Hongli , Zhang Peng , Gu Kai , Gong Yangming , Peng Peng , Shi Yan , Ai Dashan , Chen Wen , Fu Chen 
Published: October 2022

BackgroundSince 2011, through the Community-Based Colorectal Cancer Screening Program in Shanghai, China (SHcsp), residents aged &gt;50 years were offered initial colorectal cancer screening using the fecal immunochemical test (FIT) and risk assessment questionnaire (RAQ) for free. Colonoscopy was then recommended for positive results.ObjectiveTo evaluate the cost-effectiveness of the Community-Based Colorectal Cancer Screening Program in Shanghai, China from the payer perspective.MethodsThis analysis estimated the long-term cost and effectiveness of the 2014–2016 SHcsp based on real-world follow-up data from the SHcsp database, Shanghai Cancer Registry System, vital statistics from Shanghai Municipal Center for Disease Control and Prevention and inpatient CRC expense data from hospitals. A decision-tree model and Markov model were constructed to simulate the 25-year health outcomes. The screening branch was the cohort with a definite diagnosis of adenoma, advanced adenoma, and CRC. The other branch was residents who were neither screened nor treated until CRC symptoms appeared. A payer prospective was adopted to measure direct costs and effectiveness by life years (LYs) and quality-adjusted life years (QALYs) gained, and were discounted by 3%. Stimulation robustness was tested by one-way sensitivity analysis.ResultsOf 1,097,656 residents, 13,250 were diagnosed with adenoma, advanced adenoma, or CRC. Assuming those had not been found through screening, SHcsp resulted in 1,570.1 LYs and 13,984.3 QALYs gained at an extra cost of USD9.96 million. The incremental cost-effectiveness ratio (ICER) was USD6,342.02 per LY and USD712.08 per QALY obtained, far below the threshold of USD59,598 of three-time GDP per capita in Shanghai.ConclusionThe SHcsp was cost-effective than no screening strategy. The results were generalisable to the Chinese population for mass CRC screening.
FEATURES OF THE USE OF INNOVATIVE TECHNOLOGIES IN THE TEACHING OF BIOLOGY IN 7 CLASSES OF GENERAL SECONDARY EDUCATION
Authors: KOFAN I. 
Published: October 2022

The state of the problem regarding the introduction of innovative technologies in the educational process in the research of domestic and foreign scientists is analyzed.
The positive impact of the introduction of these technologies using various methods and methods of training in biology lessons in 7 classes on cognitive activity and work of schoolchildren is shown. An increase in the level of cognitive activity and school performance was established, as well as, as a result, a decrease in the level of all factors of school anxiety of students.
Research materials can be used in pedagogical activities in the teaching of biology in the 7th grade of the secondary school by teachers, as well as psychologists, students of pedagogical institutions of higher education.
INNOVATION IN TEACHING LABOR PROTECTION ACTIVITIES AND SAFETY DURING THE COVID-19 PANDEMIC
Authors: KUDRIA O. , KHOMENKO L. 
Published: October 2022

The article substantiates the need to acquaint students of pedagogical universities, as future educators, with innovative trends in labor protection, newly introduced regulations on labor protection and safety in educational institutions in the pandemic COVID-19. Students of Pedagogical Universities are Future Employees of Educational Institutions. They may later hold managerial position. It is important to form in young people an active life position, a conscious attitude to their own health and the health of others, a high level of personal social responsibility
Possibilities of updating the content of educational components "Occupational Safety", "Security science" and improving the methods of their teaching in the context of the COVID-19 pandemic have been identified. Innovations in the field of labor protection and features of formation of a new national system of occupational risk prevention on the basis of introduction at the legislative level of the risk-oriented approach in the field of the organization of safety and health of workers are analyzed.
The normative and legal documents on labor protection and life safety in the educational institution, which were adopted in connection with the COVID-19 pandemic, were considered. The specifics of the use of innovative learning technologies in the study of labor protection and safety are considered.
THE PROBLEM OF SELECTING AND STRUCTURING OF EDUCATIONAL MATERIAL IN ENGLISH WHEN TEACHING STUDENTS OF TECHNICAL SPECIALITIES
Authors: PONOMARENKO N. , PONOMARENKO V. , NEUSTROIEVA G. , TIMCHENKO G. 
Published: October 2022

The article deals with the scientifically substantiated methods of selecting and organizing educational material based on its didactic significance, taking into account the characteristics of perception, preservation and forgetting of educational information by students of technical specialities, the peculiarities of the educational process of higher education from the point of view of the influence of educational material on the formation of professional qualities of a future specialist.
This article considers such theoretical and methodological issues of selecting and structuring of educational material in English for developing students’ educational activities in the technical university in the practice of teaching a foreign language, as well as the basic requirements for mastering the knowledge in technical subjects, like Mathematics in which the language of teaching is English. The activities of future specialists, when introducing the academic mobility, depend on the content and nature of the knowledge that higher education should provide them with. A serious reason for many disadvantages in the training of specialists is the lack of scientific substantiation for the selection of the content of education at the university.
The general provisions on analysis of various options for solving this problem are given and it is estimated that the cybernetic approach is the most optimal, since it allows you to build a technology for selecting educational inaterial that ensures the continuity of learning. It is advisable to consider the presentation of the process of selection and structuring of educational material as a pedagogical technology for constructing an educational thesaurus through a description of its information-semantic structure. This approach reveals the interaction between didactic principles and parameters that characterize the semantic content of the descriptor of educational material. Analysis from the position of didactics of information-semantic structuring of educational material allows us to make a conclusion about the necessity of research in this area.
The article analyzes scientists’ views on the process of selecting and structuring of educational material as a process of an educational thesaurus. The structuring of educational material depends primarily on the specifics of the subject, on the functions that the latter performs in education, and on the general idea of the construction of the content of education. Practical recommendations are provided for selecting and structuring of educational material.
The approaches have been developed for structuring educational material that cannot be mechanically transferred to all academic subjects in the same completeness and a further study of the theory and methodology for selecting and structuring of educational material was proposed.
Association between Vital Signs Fluctuations and Pain Severity among Critically-ill Patients
Authors: Emad Ghufran , AL-Fayyadh Sadeq 
Published: October 2022

Background: Pain is a critical issue in the Intensive Care Unit and need a proper management to improve patient's outcome and reduce the pain consequences in critically ill patients since patient in the intensive care unit being unable to reporting pain. Therefore, assessment vital signs frequently may be helpful.
Methods: A descriptive-correlational design was conducted in the present study. A purposive sample of 135 subjects who had met the study's inclusion criteria were targeted. The data collection started from January 18thto April 7th, 2022.
Results: Patients were silently suffering pain during all three assessment phases pre-during and 20 minutes’ post-routine nursing procedures. Of equal importance, there is a statistically significant association between the overall pain score and overall vital signs pre, during and post nursing procedures.
Conclusions: The pain severity had reached its highest level during nursing procedures, as it showed a severe unacceptable pain score, which is both clinically and ethically unacceptable. And there was a significant statistical difference, which was authenticated through vital signs readings during nursing procedures and within 20 minutes compared to pre-nursing procedures.
Recommendations: It is recommended to depend the changes in vital readings because it is considered important indicator of pain presence and its severity among patients who are unable to express their pain in the intensive care units. Also a highly recommended that Intensive Care Units use up-to-date clinical protocols to measure pain.
Preoperative Pulmonary Rehabilitation to Prevent Postoperative Pulmonary Complications following Open Heart Surgery: A Narrative Review
Authors: Noor Jadeel , AL-Fayyadh Sadeq 
Published: October 2022

Background: Numerous medical disciplines have recognized the preoperative period as a crucial phase to enhance patient recovery and outcomes. Patients perform preoperative pulmonary rehabilitation with inspiratory or expiratory muscle training to enhance lung protection. Despite the variety of breathing techniques in the clinical setting, the literature lacks a conclusive evidence regarding which technique is more effective.
Research question:
In adult patients undergoing open heart surgeries, is preoperative pulmonary rehabilitation of benefit in preventing postoperative pulmonary complications, shorten length of stay in the intensive care unit (ICU) or hospital?
Methods: The authors conducted a search in electronic databases regarding the current evidence of preoperative pulmonary rehabilitation.
Subjects: Patients undergoing Coronary Artery Bypass Grafts (CABG) and/or valvular surgery.
Intervention: Any pulmonary intervention, such as incentive spirometer, inspiratory muscle training, exercise training or relaxation, delivered prior to surgery, single or combined.
Outcome measures: The incidence of persistent post-concussion symptoms (PPCSs), pulmonary function test (PFT), ventilation period, length of stay in ICU and hospital
Results: The authors conducted an initial search in the systematic reviews, which yielded 16 published articles. Furthermore, the authors search in the randomized controlled trials and this yielded 72 articles. The relevancy of the selected publications was determined by reviewing their titles, keyword, and abstracts. Overall a total of eight randomized controlled trials (RCTs) and six systematic reviews involving 3908 participants were included in this review.
Conclusion: Preoperative pulmonary rehabilitation utilizing various breathing techniques reduces the incidence of postoperative pulmonary complications.
Keywords
Preoperative Care, Breathing Exercises, Postoperative Complications, Coronary Artery Bypass, Cardiac Surgery.
Peningkatan Minat Belajar Siswa Melalui Pendekatan Problem Based Learning Pada Mata Pelajaran Matematika Kelas II SDN Bawuran
Authors: Azizah Ulfah 
Published: October 2022

The low interest in learning of grade II students at SDN Bawuran encouraged researchers to conduct class action research at SDN Bawuran. This study aims to (1) know the implementation of learning using the Problem Based Learning approach as an effort to increase students' learning interest in grade II mathematics subjects at SDN Bawuran, and (2) increase students' learning interest in grade II mathematics subjects at SDN Bawuran using the Problem Based Learning approach. The research method used is class action research, Kemmis &Taggart model. The subjects of this study were 23 grade II students of SD N Bawuran. The research was conducted in two cycles. Each cycle consists of two meetings. Research in an effort to increase students' learning interest through PBL in grade II mathematics subjects sdn Bawuran has been conducted with the results can increase students' learning interest, it is shown the initial condition of the average learning interest score of 61 (less interested) with a percentage of the number of students at least less interested 56%; Cycle 1 is 66 (quite interested) with a percentage of 65%; Cycle 2 is 73 (quite interested) with a percentage of 82%.
الاهتمام الاجتماعي وعلاقته بالتوافق النفسي‎ ‎لدى طلبة الجامعة
Authors: خواف أ.م.د قيس رشيد ‏ 
Published: October 2022

استهدف البحث التعرف درجة الاهتمام الاجتماعي لدى طلبة الجامعة. دلالة الفروق الاحصائية في الاهتمام الاجتماعي تبعا لمتغير النوع (ذكور – اناث) لدى طلبة الجامعة درجة التوافق النفسي لدى طلبة الجامعة. دلالة الفروق الاحصائية في التوافق النفسي تبعا لمتغير النوع (ذكور – اناث) لدى طلبة الجامعة. معرفة فيما إذا كانت هناك علاقة ارتباطية بين الاهتمام الاجتماعي والتوافق النفسي لدى أفراد العينة ككل. يتحدد البحث الحالي بطلبة جامعة الكوفة من الذكور والإناث للعام الدراسي (2018-2019) وبعد تطبيق المقاييس وتفريغ البيانات والتعامل معها احصائيا اظهرت النتائج كما يأتي, أن أفراد عينة البحث يتمتعون بالاهتمام ألاجتماعي, كما تبين ايضا انه لا يوجد فرق دال بين الذكور والإناث في الاهتمام الاجتماعي، كما أظهرت النتائج أن أفراد عينة البحث لديهم توافق نفسي, وفي نهاية البحث اوصى المجتمع توفير فرص لتنمية الاهتمام الاجتماعي من خلال فتح الدورات والندوات والأندية الاجتماعية واقترح باجراء دراسة على مفهوم الاهتمام الاجتماعي مع متغيرات اخرى مثل (التوافق الزواجي, الرضا عن العمل).
The consequences of a conviction deserving of leniency in the criminal legislation of the Russian Empire
Authors: Shayhutdinova Aygul' 
Published: October 2022

This article is devoted to the specifics of sentencing when the jury verdicts condescension under the legislation of the Russian Empire from 1864 to 1917, as well as the limits of the jury’s influence on possible punishment.
The author comes to the conclusion that the development of the institution of jurors in Russia in terms of sentencing has no historical continuity. The modern Russian court considering cases with the participation of jurors has fewer rights in its competence and rules of sentencing compared to the corresponding powers in sentencing in pre-October Russia, which indicates the need to expand the competence of jurors in the current domestic legal model.
Keywords: punishment, jurors, verdict, lad
Disposal of a land plot: abuse of the right or a variant of the “norm”
Authors: Malyutina Oksana 
Published: October 2022

The article attempts to analyze the market for the lease of land plots in state and municipal ownership. The author considers the features of a land plot as a subject of a lease agreement, its characteristics as an individually defined thing and the possibility of using land plots as a financial asset.
Among the characteristics of a land plot as the subject of a lease agreement, its purpose, associated with the type of permitted use, is considered. The author provides an analysis of law enforcement practice aimed at changing the type of permitted use of a land plot provided for temporary use by individuals or legal entities, and explores the need to amend the land lease agreement.
The author suggested that the ambiguity in the interpretation of the procedure for changing the type of permitted use, and, as a result, making changes to the lease agreement, can be eliminated by including, by agreement of the parties, in the agreement a condition on the impossibility of changing the type of permitted use during the term of the agreement.
The dispositiveness of civil law makes it possible to include this condition in the contract and avoid both the abuse of the right and the possibility of concluding “speculative transactions” to replace the party to the obligation in order to circumvent competitive procedures.
PENERAPAN BUILDING INFORMATION MODELLING (BIM) PADA PROYEK PEMBANGUNAN WORKSHOP (STUDI KASUS: PROYEK PEMBANGUNAN WORKSHOP KAPAL DI SEKUPANG)
Authors: Ferry Ferry , Indrastuti Indrastuti 
Published: October 2022

Pembangunan bidang konstruksi yang semakin meningkat menuntut pihak pelaksana pembangunan untuk penyelesaian aktivitas proyek dengan lebih cepat dan efisien. Pada pelaksanaan proyek konstruksi umumnya banyak menghadapi permasalahn baik kegiatan dengan waktu, biaya maupun mutu. Mengaplikasikan BIM sampai pemodelan 4D dan menganalisi kinerja waktu pada proyek pembangunan workshop kapal merupakan tujuan dari penelitian ini. Software yang digunakan dalam proses pemodelan adalah Revit Structure, Navisworks. Pemodelan 3D diantaranya terdapat pondasi, kolom, balok, pelat dan atap. Menggabungkan jadwal atau schedule dengan model 3D akan menghasilkan pemodelan 4D didalam software Autodesk Navisworks. Analisis kinerja waktu yang dilakukan menggunakan metode kurva S. Penerapan BIM telah dilakukan hingga memperoleh model dalam bentuk 3D dan 4D. Berdasarkan nilai deviasi, proyek ini tidak mengalami keterlambatan sama sekali. Nilai deviasi positif tertinggi +19.15% dan terendah +7.33%. Serta melakukan perhitungan anggaran biaya berdasarkan pemodelan di revit structure dengan total biaya Rp. 5.813.838.429.
EVALUASI SARANA PRASARANA PENUNJANG KESIAPSIAGAAN GEDUNG A UNIVERSITAS SEMARANG TERHADAP RESIKO BENCANA KEBAKARAN
Authors: Kuncoro Ahmad Hakim Bintang , Zhafira Talitha 
Published: October 2022

Fire disaster is one of the disasters that is very detrimental to the community both in terms of casualties and property and assets that are invaluable. Building A University of Semarang (USM) and the assets in it are very important things to maintain. Several USM buildings have been equipped with facilities regarding fire preparedness, but most of the USM buildings also do not have these facilities completely. Apart from the facilities, the building occupants' knowledge of fire disaster preparedness cannot yet be known to what extent their understanding is. Evaluation of infrastructure which refers to the standards set by the government needs to be carried out. This can increase awareness and can also minimize losses that can occur. So that activities that take place in the USM area can run well and calmly. There is a significant relationship with a strong enough to strong and positive direction correlation level between the combination of the relationship between 2 variables consisting of HR, Program, and Facilities variables. The residents of building A USM are considered to be ready to face the risk of fire disasters, although the current condition of supporting facilities for fire disaster preparedness is deemed necessary to be added.
Keywords: fire disaster, preparedness, building A USM.
EVALUASI PENJADWALAN PROYEK DENGAN METODE LINE OF BALANCE (STUDI KASUS : HOTEL SANTIKA BATAM)
Authors: Sudarson Willim 
Published: October 2022

With the development of technology and information, Indonesia's construction also continues to develop. This can be seen from the many construction projects that are being carried out or that have been completed in Indonesia. In the construction project process, of course it will involve project management so that the construction project goes according to plan and can utilize resources effectively, one of them is by arranging project work scheduling. This study aimed to evaluate project scheduling using the Line of Balance method. The research discussion would include determining the duration of work using the Line of Balance method, comparing the duration of work with existing scheduling and identifying the advantages of project scheduling with the Line of Balance method. The research data util ized scheduling from Santika Hotel Batam construction project. The use of scheduling Line of Balance has advantages in determining the time to start work arranged with each work package.

Keywords : evaluation, scheduling, construction projects, Line of Balance