bluuebunny/crossref_metadata_2025_split huggingface dataset:
The promising prognostic value of vagal nerve activity at the initial management of ovarian cancer
Authors: Cherifi François , Lefevre Arbogast Sophie , Font Jonaz , Abdeddaim Cyril , Becourt Stephanie , Penel Nicolas , Coquan Elodie , Lequesne Justine , Gidron Yori , Joly Florence 
Published: November 2022

ObjectiveIdentifying new modifiable prognostic markers is important for ovarian cancer (OC). Low parasympathic activity is associated with inflammation, oxidative stress and sympathetic nervous system activation. Previous studies reported that low vagal nerve activity, measured by low heart rate variability (HRV), may predict poor cancer prognosis. We aimed to examine the prognostic value of HRV in OC.MethodsThis bicentric retrospective study included patients diagnosed with serous OC FIGO stage ≥IIB, between January 2015 and August 2019, with electrocardiograms (ECG) available around diagnosis. HRV was measured from ECG using the time domain parameter of standard deviation of all normal-to-normal heartbeat intervals (SDNN). Optimal SDNN cut-off was determined using the Youden index criteria of time-dependent ROC curves. We used multivariate cox proportional hazard models to investigate the association between HRV and overall survival (OS), while adjusting for well-known OC prognostic factors.ResultsThe 202 patients included were 65.7 years-old on average, 93% had stage FIGO IIIC/IV, 56% had complete surgical resection. Median OS was 38.6 months [95%CI:34.4-47.4]. The median SDNN was 11.1ms, with an optimal cut-off of 10ms to predict OS. OS was shorter for patients with low HRV compared to high HRV (26.4 vs 45.1 months; p&lt;0.001). In multivariate analysis, HRV remained an independent prognostic factor with a two-fold higher risk of death among patients with low SDNN compared to those with high SDNN (HR=2.03, 95%CI=1.35-3.06, p&lt;0.001).ConclusionLow HRV, was associated with worse OS in OC patients, supporting previous studies on the prognostic role of HRV in cancer. If replicated in prospective studies, vagal nerve activity may be a new therapeutic target in OC.
Efficacy and feasibility of snare-assisted endoscopic resection of small submucosal gastric tumors: A retrospective analysis
Authors: Zhao Fei , Liu Zhenzhen , Wei Anwei , Wang Wei , Xu Na , Pu Xuanmei 
Published: November 2022

Background and aimThe prevalence of small submucosal gastric tumors is rising. Despite the fact that high success rate of endoscopic resection of small submucosal gastric tumors originating from the muscularis propria has been reported, the procedure is technically challenging and has a high rate of complications. In this study, we investigated the efficacy and feasibility of a novel snare-assisted endoscopic resection technique for small submucosal gastric tumors.Patients and methodsThis is a single-center consecutive study of 50 patients who were diagnosed with small submucosal gastric tumors originating from the muscularis propria and who subsequently underwent snare-assisted endoscopic resection between January 2019 and January 2021 at our hospital. Data on the demographic characteristics, procedural success rate, complications, recurrence rate, and histopathology of the resected specimen were collected and analyzed retrospectively.ResultsThe majority of the patient’s population was male (66%) with the mean age of 48.4 ± 9 years (range, 20–70 years). The mean size of the tumor confirmed by endoscopic ultrasonography was 6.4 ± 1.6 mm (range, 3.1–9.8 mm). All the tumors were resected successfully using snare-assisted endoscopic resection technique. The mean procedure time was 22.8 ± 9.6 (range, 15–35 min). The technical (performed the procedure successfully without converting to surgery) and clinical (the patient fully recovered after the procedure without experiencing any complications) success rate of the procedure was 100%. Eighteen (24%) patients had very small amount of mucosal damage, and wound closure was not needed in these patients. During 6–24 months of follow-up, no recurrence or metastasis occurred. No adverse event was noted during the follow-up time.ConclusionThe novel approach of snare-assisted endoscopic resection is simple, feasible, and effective for tumors with small size and originating from the gastric muscularis propria. In addition, it offers a better alternative therapy for the complete resection of small submucosal gastric tumors. Its advantages compared with traditional endoscopic approaches such as endoscopic submucosal resection and endoscopic submucosal dissection include shorter procedure times, lesser cost, and a lower rate of complications (perforation, bleeding, and infection).
Nutrition management for patients with head and neck cancer during peri-radiotherapy: A systematic review and quality appraisal of clinical practice guidelines using the AGREE II instrument
Authors: Zhao Jing , Kan Yajing , Wu Xueting , Yang Shuang , Wang Guozhou , Bao Yuting , Li Jing 
Published: November 2022

ObjectiveTo evaluate the quality of clinical practice guidelines (CPGs) for nutrition management of patients with head and neck cancer (HNC) during peri-radiotherapy, as well as to summarize the nutrition recommendations fitting the subject.MethodsCPGs published in English, Chinese and German were identified from databases, guideline networks, and websites of nutritional associations from the databases’ inception to March 8, 2022. Three independent appraisers used the Appraisal of Guidelines for Research and Evaluation II (AGREE II) Instrument to assess the quality of CPGs. The intraclass correlation coefficient (ICC) was used to calculate appraiser agreement.Results769 records were identified. After removing duplicates, 470 articles were screened. 12 CPGs were identified with nutrition-specific recommendations. 67% of CPGs were rated as high quality, and 33% as low quality. Recommendations were categorized into nutritional risk screening, nutrition assessment, nutrition counseling, nutrition interventions, nutrition intake, swallowing function management, weight management, exercise, multidisciplinary team, post-discharge care, nutrients, and pharmacologic interventions.ConclusionWe found discrepant recommendations in existing CPGs, including nutrition screening, nutrition assessment, nutrition intake, and nutrients. We also reported the absence of essential parts of CPGs, including the views of its target users, the statement of external review, the method to formulate the recommendations, strategies to improve uptake, and resource implications of applying the CPGs. CPGs with low quality should be improved in future updates based on currently available guideline development tools. Specialized CPGs on nutrition management for HNC patients during peri-radiotherapy should be developed.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/index.php, identifier CRD42022320322.
Immune checkpoint inhibitors alone or in combination with chemotherapy for treatment of advanced non-small cell lung cancer after first-line platinum-based chemotherapy: A propensity score matching analysis
Authors: Qiu Lupeng , Gao Shan , Du Sicheng , Sun Shengjie , Liang Yanjie , Sun Zhuoya , Li Tao , Jia Guhe , Li Ke , Sun Xiaohui , Jiao Shunchang , Zhao Xiao 
Published: November 2022

BackgroundImmune checkpoint inhibitors (ICIs) have changed the treatment landscape of several cancer types. However, data are lacking with regard to the clinical responsiveness of ICIs in patients with advanced non-small cell lung cancer (NSCLC) after standard first-line chemotherapy. Therefore, we aimed to evaluate the clinical efficacy of ICI alone or in combination with chemotherapy for patients with advanced NSCLC after first-line platinum-based chemotherapy.MethodsWe retrospectively collected patients with confirmed advanced NSCLC who underwent ICI monotherapy or ICI plus chemotherapy after first-line platinum-based chemotherapy between January 2018 and December 2020. A propensity score matching analysis was used to balance baseline characteristics between the two treatment groups. Kaplan-Meier methods and multivariable Cox regressions were used for survival analyses.ResultsAmong 832 eligible patients, 222 received ICI monotherapy and 610 received ICI plus chemotherapy. The median overall survival (OS) of patients who received ICI plus chemotherapy was 16.0 months compared with 13.1 months in patients who received ICI monotherapy (HR: 0.64, 95% CI: 0.49-0.85, P = 0.002). After 1:1 propensity score matching, all baseline characteristics were well-balanced between the two treatment groups. Patients who received ICI plus chemotherapy had significantly longer OS than those who received ICI monotherapy (NR vs. 13.1 months, HR: 0.50, 95% CI: 0.34-0.71, P &lt; 0.001). Meanwhile, the median time to treatment discontinuation was 4.4 months in the ICI-chemo group and 3.5 months in the ICI-mono group (HR: 0.72, 95% CI: 0.58-0.89, P = 0.002). The multivariate analysis indicated that treatment regimen was an independent prognostic factor for OS (HR: 0.488, 95% CI: 0.337-0.707, P &lt; 0.001). Moreover, a nomogram that integrated both treatment regimens and clinicopathological factors was created for survival prediction.ConclusionOur study indicated that patients with advanced NSCLC who received ICI plus chemotherapy after first-line platinum-based chemotherapy tended to have longer OS than those who received ICI monotherapy. The multivariate analysis showed that treatment regimen was an independent prognostic factor for OS. Future prospective studies are needed to confirm these findings.
Pediatric unicystic cystic partially differentiated nephroblastoma: The first case report
Authors: Chao Liu , Lei Zhang , Xiang Li , Qi Zhou 
Published: November 2022

Cases of patients with cystic partially differentiated nephroblastoma (CPDN) have been reported to date, which presented as polycystic renal tumor in all of them. It is a special pathological type of nephroblastoma. Here, we report the first case of a unicystic CPDN in a child. The patient was diagnosed with a simple renal cyst and underwent laparoscopic decortication. The naive nephron was found in the pathological section, and the diagnosis of CPDN was confirmed. The patient then underwent a radical nephrectomy and six cycles of postoperative chemotherapy. There was no recurrence or metastasis after 2 years of follow-up. Pediatric CPDN presenting as a unicystic renal tumor poses a new challenge to the diagnosis, differential diagnosis, and treatment of unicystic renal tumor.
Consumers’ coping strategies when they feel negative emotions in the face of forced deconsumption during the Covid-19 pandemic lockdowns
Authors: Ertz Myriam , Tandon Urvashi , Yao Quenum Gautier G. , Salem Mohammed , Sun Shouheng 
Published: November 2022

IntroductionThis paper explores consumers’ coping strategies when they feel negative emotions due to forced deconsumption during the Covid-19 pandemic lockdowns.MethodsThe tool used for data collection is the questionnaire. It was made using the LimeSurvey software. A total of 621 complete observations were analyzed.ResultsThe findings demonstrate that anger positively influences the activation of seeking social support, mental disengagement, and confrontive coping strategies. Besides, disappointment activates mental disengagement but only marginally confrontive coping and not behavioral disengagement. Furthermore, regret is positively related to confrontive coping, behavioral disengagement, acceptance, and positive reinterpretation. Finally, worry positively impacts behavioral disengagement, self-control, seeking social support, mental disengagement, and planful problem-solving.DiscussionThe study’s originality lies in its investigation of consumers’ coping strategies when experiencing negative emotions due to forced deconsumption in the context of the Covid-19 pandemic.
Remote PEERS® for preschoolers: A pilot parent-mediated social skills intervention for young children with social challenges over telehealth
Authors: Factor Reina S. , Glass Leila , Baertschi Daliah , Laugeson Elizabeth A. 
Published: November 2022

IntroductionSocial differences characteristic of autism spectrum disorder (ASD) and other developmental disabilities are evident in early childhood and are associated with later difficulties. Unfortunately, there is a paucity of evidence-based interventions explicitly targeting social skills development for young children, few actively integrate parents and caregivers, and even fewer have remote models. The importance of providing accessible, tailored services for families in the wake of the COVID-19 pandemic, prompted the creation of a parent-mediated telehealth version of Program for the Education and Enrichment of Relational Skills (PEERS®) for Preschoolers (P4P), a pre-existing, evidence-based social skills intervention for children 4–6 years focused on making and keeping friends.MethodThis methodological paper documents the implementation, feasibility, and satisfaction of a novel telehealth group-based delivery of P4P.ResultsQualitative results indicate acceptable feasibility and satisfaction. Additionally, following completion there was an increase in parental confidence in social coaching and increased use of child social skills.DiscussionFuture work will evaluate quantitative outcomes and comparisons between delivery methods (e.g., telehealth vs. in-person).
Spike protein of SARS-CoV-2 Omicron variant: An in-silico study evaluating spike interactions and immune evasion
Authors: Jimenez Ruiz Jose A. , Lopez Ramirez Cecilia , Lopez-Campos Jose Luis 
Published: November 2022

BackgroundThe fundamentals of the infectivity and immune evasion of the SARS-CoV-2 Omicron variant are not yet fully understood. Here, we carried out an in-silico study analyzing the spike protein, the protein electrostatic potential, and the potential immune evasion.MethodsThe analysis was based on the structure of the spike protein from two SARS-CoV-2 variants, the original Wuhan and the Botswana (Omicron). The full-length genome sequences and protein sequences were obtained from databanks. The interaction of the spike proteins with the human Angiotensin Converting Enzyme 2 (ACE2) receptor was evaluated through the open-source software. The Immune Epitope Database was used to analyze the potential immune evasion of the viruses.ResultsOur data show that the Omicron spike protein resulted in 37 amino acid changes. The physicochemical properties of the spike had changed, and the electrostatic potentials differed between both variants. This resulted in a decrease in protein interactions, which does not establish a greater interaction with the ACE2 receptor. These changes compromise key receptor-binding motif residues in the SARS-CoV-2 spike protein that interact with neutralizing antibodies and ACE2.ConclusionsThese mutations appear to confer enhanced properties of infectivity. The Omicron variant appears to be more effective at evading immune responses.
Sexual and reproductive health and access: Results of a rapid epidemiological assessment among migrant peoples in transit through Darién, Panamá
Authors: Erausquin Jennifer Toller , Sánchez Joanne , Yu Pon Anyi , Jhangimal Mónica , Millender Eugenia , Peña Yudith , Ng Winroy , Reina Adelys , Nakad Candy , Quintana Joselid , Herrera Veces Roberto , Vistica Grace , Pinzón-Espinosa Justo , Cabezas-Talavero Gonzalo , Katz Jennifer , Pascale Juan Miguel , Rodríguez-Álvarez Fátima , Gabster Amanda 
Published: November 2022

BackgroundThe foot transit of migrant peoples originating from the Caribbean, South America, Asia, and Sub-Saharan Africa through the Darién Forest (DF) in Eastern Panamá towards North America has increased in recent years from approximately 30,000 people/year to &gt;133,000 in 2021. In the DF, there is no food/housing provision nor healthcare access. Very little is known of sexual and reproductive health (SRH) among this population. This study used rapid epidemiological methods to describe the SRH situation among migrant peoples in transit through the DF.MethodsThis cross-sectional study randomly selected migrant people in transit (men and women) at a Migrant Reception Station in Darién, Panamá, between January 4–11, 2022. Data collection included a self-applied questionnaire (≥18 years); clinical screening (≥12 years); and HCG, treponemal antibodies, and HIV(I/II) lateral-flow tests with blood samples (≥12 years). Descriptive analyses were used to report findings.ResultsIn all, 69 men and 55 women participated in the self-applied questionnaire, 70 men and 51 women in clinical screening; 78 men and 63 women in HCG, treponemal antibody and HIV testing. Overall, 26.1% (18/69) men and 36.4% (20/55) women reported sexual intercourse within the past month. The last sex partner was casual among 43.0% (21/49) of men and 27.8% (10/36) of women; of those, 42.9% (9/21) of men and 80.0% (8/10) of women reported this sex was condomless. Among women, 20.0% (11/55) tested positive for pregnancy; 5 of these pregnancies were planned. Of those screened, a reproductive tract infection symptom was reported by 5.7% (4/70) of men and 58.8% (30/51) of women. A total of 32.7% (18/55) of men and 18.2% (8/44) of women reported no prior HIV testing. Of 78 men, HIV and treponemal antibodies were found among 1.3% (n = 1) and 2.6% (n = 2), and among 63 women, 3.2% (n = 2) and 3.2% (n = 2), respectively.ConclusionsThis rapid epidemiological assessment found high recent sexual activity, low condom use with casual partners, and a need for increased HIV and syphilis testing and treatment. There is a need for increased testing, condom provision, and SRH healthcare access at migrant reception stations that receive migrant peoples in transit through Panamá.
Assessing the demographics of the 2021 and 2022 CEDAR workshop
Authors: Jones McArthur , Maute Astrid 
Published: November 2022

The Coupling, Energetics and Dynamics of Atmospheric Regions (CEDAR) community is made of engineers, scientists, physicists, and students with a mission to understand the fundamental properties and predictability of the space-atmosphere interaction region, including the mesosphere, thermosphere, ionosphere, and inner magnetosphere. At the 2020 CEDAR annual workshop, community-wide feedback received on diversity, equity, and inclusion (DEI) in CEDAR warranted a grassroots effort focused on addressing the DEI issues raised. This led to the creation of the CEDAR DEI task force, whose goals were to 1) Assess and formalize DEI efforts in CEDAR; 2) Establish and normalize a DEI presence in the CEDAR community; and 3) Foster improvement in CEDAR through implementation of actionable initiatives that promote diversity, equity, and inclusion. Of these actionable items collecting demographic information on those participating in the Annual CEDAR Workshop was identified as the top priority. This paper therefore, reports the demographic information obtained from CEDAR registrants for the virtual workshop in 2021 and in-person workshop in 2022. In general, the demographics of CEDAR are consistent with those in broader science, technology, engineering, and mathematics (STEM) fields, that is, most participants identify as male, White, and or Asian/Middle Eastern. On average, women and historically underrepresented races and ethnicities in STEM fields make up roughly 30% and 10%, respectively, of all 2021 and 2022 CEDAR Workshop registrants over the past 2 years. We further discuss the demographics of CEDAR relative to reports published in recent years by other organizations, where possible.
Analysis of a Capacitive Sensing Circuit and Sensitive Structure Based on a Low-Temperature-Drift Planar Transformer
Authors: Sui Yanlin , Yu Tao , Wang Longqi , Wang Zhi , Xue Ke , Chen Yuzhu , Liu Xin , Chen Yongkun 
Published: November 2022

In space gravitational-wave-detection missions, inertial sensors are used as the core loads, and their acceleration noise needs to reach 3×10−15 ms−2/Hz at a frequency of 0.1 mHz, which corresponds to the capacitive sensing system; the capacitive sensing noise on the sensitive axis needs to reach 1 aF/Hz. Unlike traditional circuit noise evaluation, the noise in the mHz frequency band is dominated by the thermal noise and the 1/f noise of the device, which is a challenging technical goal. In this paper, a low-frequency, high-precision resonant capacitor bridge method based on a planar transformer is used. Compared with the traditional winding transformer, the developed planar transformer has the advantages of low temperature drift and low 1/f noise. For closed-loop measurements of capacitive sensing circuits and sensitive structures, the minimum capacitive resolution in the time domain is about 3 aF, which is far lower than the scientific measurement resolution requirement of 5.8 fF for gravitational wave detection. The capacitive sensing noise is converted to 1.095 aF/Hz in the frequency band of 10 mHz–1 Hz. Although there is a gap between the closed-loop measurement results and the final index, the measurement environment is an experimental condition without temperature control on the ground; additionally, in China, the measurement integrity and actual measurement results of the capacitive sensing function have reached a domestic leading level. This is the realization of China’s future space gravitational wave exploration.
Cuidados paliativos e qualidade de vida de pacientes com doenças crônicas: uma revisão integrativa
Authors: Da Silva Crivelaro Patrícia Maria , Giacomini Cerri Giovanna , Santos Leandro Jaqueline , De Castro Nascimento Rafael , De Souza Bacci Marques Ana Claudia , Justina Papini Silvia 
Published: November 2022

Objetivo: Abordar as evidências científicas sobre as estratégias paliativas utilizadas para melhorar a qualidade de vida em pacientes com doenças crônicas ameaçadoras de vida.
Metodologia: Revisão integrativa da literatura baseada no seguinte questionamento: Considerando os pacientes com doenças crônicas, quais as estratégias paliativistas e seus contributos na qualidade de vida? O levantamento bibliográfico foi realizado nas bases LILACS e MEDLINE, sendo selecionados artigos dos últimos cinco anos, em português, inglês e espanhol.
Resultados: Os seis artigos analisados desvelaram o seguinte eixo temático: Estratégias paliativistas utilizadas para aumentar a qualidade de vida em pacientes com doenças crônicas nas redes de atenção à saúde.
Considerações Finais: Este estudo evidenciou estratégias de cuidados paliativos importantes para a qualidade de vida de doentes crônicos, não existindo uma lista ou padrão para essas estratégias, as quais devem ser discutidas e inovadas dentro da equipe de saúde, além de precisarem ser mais estudadas.
Atividades extracurriculares em urgência e emergência: contribuições da liga acadêmica para formação dos estudantes de enfermagem
Authors: Neves Arantes Paulino Yuri , Do Nascimento Martins de Araujo Gabriela 
Published: November 2022

Objetivo: Relatar as experiências que os estágios extracurriculares, no âmbito das urgências, atribuíram à formação de acadêmicos em enfermagem.
Método: Trata-se de um relato descritivo, sobre as experiências das atividades extracurriculares oferecidas pela Liga Acadêmica do Trauma e Emergência (LATE) da Universidade Federal de Juiz de Fora e das contribuições oportunizadas aos acadêmicos de enfermagem pela realização de plantões no Serviço de Atendimento Móvel de Urgência (SAMU)
Resultados: Os estágios extracurriculares possibilitaram melhor articulação entre os conteúdos teóricos e as vivências práticas e oportunizou a aproximação dos acadêmicos de enfermagem das rotinas do serviço de atendimento às urgências e emergência.
Considerações Finais: A inserção dos acadêmicos de enfermagem nessas atividades despontou-se como uma importante estratégia para articular os conteúdos da graduação com as vivências da rotina do serviço de saúde.