bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yoga als Add-on Therapie zu Dialektisch Behavioraler Therapie Sucht – Effekte auf die innere Anspannung von Patient:innen mit Substanzgebrauchsstörung und komorbider Borderline-Persönlichkeitsstörung
Authors: Bumb J. Malte , Wisch Christian , Riegler Alisa , Schuster Rilana , Reinhard Iris , Frischknecht Ulrich , Kiefer Falk , Koopmann Anne 
Published: August 2022

ZusammenfassungZiel der Studie Patient:innen mit komorbid auftretenden Substanzgebrauchsstörungen (SUD) und Borderline-Persönlichkeitsstörung (BPD) sind in ihrer Lebensqualität stark beeinträchtigt. Zusätzlich entstehen durch diese Komorbidität hohe direkte und indirekte Gesundheitskosten. Bisher sind die Behandlungsergebnisse bei dieser Komorbidität unbefriedigend und wirksame Add-on Strategien zu den etablierten Therapiekonzepten fehlen. Das Ziel dieser Studie war es, zu untersuchen, inwiefern Trauma Informed Hatha Yoga als ergänzendes Therapieelement zu einer stationären Dialektisch Behavioralen Therapie Sucht (DBT-S) die Veränderung der inneren Anspannung bei Patient:innen mit einer SUD und einer BPD modifizieren kann.Methodik In diese quasi experimentelle Studie konnten 39 Patient:innen, die an einer SUD und einer BPD leiden, eingeschlossen werden. Alle Patient:innen nahmen zum Studienzeitpunkt an einer zwölfwöchigen stationären psychotherapeutischen Behandlung im Rahmen der Dialektisch Behavioralen Therapie Sucht (DBT-S) teil. Die Teilnehmenden der Interventionsgruppe absolvierten begleitend hierzu für acht Wochen wöchentliche Trauma Informed Hatha Yoga Übungseinheiten. Die Veränderungen der inneren Anspannung der Patient:innen durch die Trauma Informed Hatha Yoga-Übungseinheiten wurden mithilfe einer visuellen Analogskala gemessen (VAS; 0–100).Ergebnisse Bei der Durchführung der Varianzanalyse mit Messwiederholungen bezüglich der Veränderungen der inneren Anspannung (Δ VAS) als abhängige Variable fanden wir einen signifikanten Interaktionseffekt Zeit x Gruppe, also einen unterschiedlichen zeitlichen Verlauf der Veränderungen der inneren Anspannung (Δ VAS) in den beiden Studiengruppen. Die Teilnehmenden der Kontrollgruppe zeigten hierbei im zeitlichen Verlauf signifikant unterschiedliche Veränderungen der inneren Anspannung (Anstiege und Abstiege), wohingegen sich in der Interventionsgruppe die innere Anspannung durch Yoga gleichmäßig reduzierte, Anspannungsspitzen also signifikant besser geglättet werden konnten.Schlussfolgerung Trauma Informed Hatha Yoga in Kombination mit der Teilnahme an einem stationären DBT-S Programm scheint basierend auf unseren Ergebnissen die Variabilität von innerer Anspannung bei Patient:innen mit SUD und BPD effektiver modifizieren zu können als eine alleinige stationäre DBT-S Therapie. Es erscheint daher sinnvoll, Trauma Informed Hatha Therapieeinheiten als ergänzende Elemente in DBT-S Therapiekonzepte zu integrieren.
Synthesis of 3-Aryl- and 3-Alkynylbenzofurans in the Presence of a Supported Palladium Catalyst
Authors: Skoda-Földes Rita , Nagy Enikő , Nagymihály Zoltán , Kollár László , Fonyó Máté 
Published: August 2022

AbstractSuzuki and Sonogashira coupling reactions of 3-iodo-2-phenylbenzofuran, leading to the corresponding 3-aryl- and 3-alkynyl derivatives, respectively, were carried out using a silica supported pyridinium ionic liquid-based heterogeneous catalyst. Under optimized reaction conditions, arylboronic acids with either electron-withdrawing or -donating substituents as well as terminal alkynes with aromatic or aliphatic groups could be coupled to the benzofuran skeleton efficiently. The application of this catalyst made it possible to carry out the reaction under phosphine-free and, in the case of the Sonogashira coupling, under copper-free conditions. The catalyst retained its activity in at least 7 subsequent runs in both types of reactions. Palladium leaching of less than 1% of the original amount used in the catalytic reaction was observed under optimized conditions in most cases. The methodology was applied successfully to the synthesis of nine different 3-aryl- and ten different 3-alkynylbenzofuran derivatives in moderate to high yields.
Beta-Secretase-1 Antisense RNA Is Associated with Vascular Ageing and Atherosclerotic Cardiovascular Disease
Authors: Bampatsias Dimitrios , Mavroeidis Ioannis , Tual-Chalot Simon , Vlachogiannis Nikolaos I. , Bonini Francesca , Sachse Marco , Mavraganis Georgios , Mareti Alexia , Kritsioti Chrysoula , Laina Ageliki , Delialis Dimitrios , Ciliberti Giorgia , Sopova Kateryna , Gatsiou Aikaterini , Martelli Fabio , Georgiopoulos Georgios , Stellos Konstantinos , Stamatelopoulos Kimon 
Published: August 2022

Background The noncoding antisense transcript for β-secretase-1 (BACE1-AS) is a long noncoding RNA with a pivotal role in the regulation of amyloid-β (Aβ). We aimed to explore the clinical value of BACE1-AS expression in atherosclerotic cardiovascular disease (ASCVD).
Methods Expression of BACE1-AS and its target, β-secretase 1 (BACE1) mRNA, was measured in peripheral blood mononuclear cells derived from 434 individuals (259 without established ASCVD [non-CVD], 90 with stable coronary artery disease [CAD], and 85 with acute coronary syndrome). Intima-media thickness and atheromatous plaques evaluated by ultrasonography, as well as arterial wave reflections and pulse wave velocity, were measured as markers of subclinical ASCVD. Patients were followed for a median of 52 months for major adverse cardiovascular events (MACE).
Results In the cross-sectional arm, BACE1-AS expression correlated with BACE1 expression (r = 0.396, p < 0.001) and marginally with Aβ1–40 levels in plasma (r = 0.141, p = 0.008). Higher BACE1-AS was associated with higher estimated CVD risk assessed by HeartScore for non-CVD subjects and by European Society of Cardiology clinical criteria for the total population (p < 0.05 for both). BACE1-AS was associated with higher prevalence of CAD (odds ratio [OR] = 1.85, 95% confidence interval [CI]: 1.37–2.5), multivessel CAD (OR = 1.36, 95% CI: 1.06–1.75), and with higher number of diseased vascular beds (OR = 1.31, 95% CI: 1.07–1.61, for multiple diseased vascular beds) after multivariable adjustment for traditional cardiovascular risk factors. In the prospective arm, BACE1-AS was an independent predictor of MACE in high cardiovascular risk patients (adjusted hazard ratio = 1.86 per ascending tertile, 95% CI: 1.011–3.43, p = 0.046).
Conclusion BACE1-AS is associated with the incidence and severity of ASCVD.
HFIP-Induced Allylation Reaction of Tertiary Allylic Alcohols with Thiols or Sulfonyl Hydrazines to Access Allylic Organosulfurs
Authors: Tong Qing-Xiao , Zhong Jian-Ji , Lu Maojian , Zhang Rong-Jin , Zhu Can-Ming , Xiao Yonghong , Chen Jian-Rui , Zhao Lei-Min 
Published: August 2022

AbstractA simple and transition-metal-free HFIP-induced allylation reaction of tertiary allylic alcohols with thiols or sulfonyl hydrazine derivatives was reported for the efficient and highly selective synthesis of allylic sulfides and allylic sulfones. Herein, HFIP played a vital role in not only activating the allylic alcohol, but also stabilizing the allylic cation intermediate to accelerate the subsequent transformations.
Comparative Effectiveness of Pre-Identified Homeopathic Medicines in Asymptomatic COVID-19 Individuals Receiving Standard Care—An Open-Label, Randomized, Controlled Exploratory Trial
Authors: Varanasi Roja , Tomar Sunita , Gupta Sanjay , Jaiswal Praveen , Srivastava Ankit , Parmar Vijendra , Chauhan Shradha , Kumar Arvind , Mishra Shivendra Kumar , Khurana Anil 
Published: August 2022

Abstract
Background Asymptomatic COVID-19 subjects can transmit the infection for as many as 14 days and are regarded as a significant factor in the rapid spread of the COVID-19 pandemic. This exploratory study aimed to determine any additional benefits of selected homeopathic medicines compared with placebo in asymptomatic COVID-19 individuals receiving standard care.
Methods This open-label, randomized, placebo-controlled, exploratory trial was undertaken at a COVID Care Centre (CCC) in Madhya Pradesh, India. Patients (n = 200, 18–65 years, both sexes) having a positive RT-PCR and asymptomatic during admission were enrolled. They were randomly assigned to one of four groups (each n = 50): Arsenicum album 30C (Ars. alb.), Camphora 1M (Camph.), Bryonia alba 30C (Bry. alb.) and placebo (Pl.). All the patients were given standard care. The primary outcome was the number of patients becoming RT-PCR negative for SARS-CoV-2 at days 5, 10 and 15.
Results In total, 200 asymptomatic COVID-19 patients were enrolled. One hundred and seventy-seven patients became RT-PCR negative by day 15; 88%, 80%, 98% and 88% from Ars. alb., Camph., Bry. alb. and Pl. respectively. A Chi-square test of association for the total patients who became RT-PCR negative for SARS-Cov-2 in each group showed a marginal statistical significance (Chi-square: 8.1, p = 0.04). A two-proportion Z-test comparing each pre-identified homeopathic medicine with placebo showed marginal statistical significance (p = 0.05) for Bry alb. only. Median time in days to RT-PCR negative (Kaplan Meier analysis) was 10 days in each of the groups.
Conclusion There was some evidence that, compared with Ars alb., Camph. or Pl., Bry. alb. was associated with an increased number of patients who became RT-PCR negative for COVID-19 by day 15. The possible effect exerted needs to be investigated in additional research.
Computed Tomography Evaluation of the Paranasal Sinuses in Adults with Primary Ciliary Dyskinesia
Authors: Plantier Diogo Barreto , Pilan Renata R. M. , Athanazio Rodrigo , Olm Mary Anne K. , Gebrim Eloisa M. S. , Voegels Richard Louis 
Published: August 2022

Abstract
Introduction Primary ciliary dyskinesia is a rare inherited disease that results in a malfunction of mucociliary clearance and sinonasal complaints. Aplasia/hypoplasia of the frontal and sphenoid sinuses has been described as more frequent in this population. However, to date, no studies have provided a detailed description of computed tomography findings in adult patients with a diagnosis of this condition.
Objective To describe the computed tomography (CT) findings of adult patients with primary ciliary dyskinesia.
Methods Retrospective observational study of adult patients with primary ciliary dyskinesia who underwent CT.
Results Twenty-one adults were included in the study. Aplasia occurred in 38.1% of frontal sinuses and in 14.3% of sphenoid sinuses. Likewise, hypoplasia occurred in 47.6% of the frontal sinuses, in 54.8% of the sphenoid sinuses and in 40.5% of the maxillary sinuses. Furthermore, trabecular loss was identified in 61.9% ethmoidal sinuses. The mean Lund-Mackay score was 13.5. In addition, 9.5% of the patients had concha bullosa, 47.6% had marked bilateral inferior turbinate hypertrophy, 38.1% had marked middle turbinate hypertrophy, and 47.6% had marked septal deviation. Finally, we identified images suggestive of fungus ball, mucocele, osteoma, a possible antrochoanal polyp, and frontal bone erosions.
Conclusion The present study provides a detailed description of CT findings in patients with primary ciliary dyskinesia. We also describe abnormalities that must be identified for safer surgical planning and that suggest a diagnosis of primary ciliary dyskinesia if found in patients with a consistent clinical picture.
Oral Health Status of Illicit Drug Users in a Health District in South Africa
Authors: Mukhari-Baloyi Ntsakisi , Bhayat Ahmed , Madiba Thomas K. , Nkambule Ntombizodwa R. 
Published: August 2022

AbstractObjectives The prevalence of illicit drug use and its associated oral health complications have been increasing in South Africa (SA). There has been a paucity of studies to determine the oral health status among illicit drug users in SA. This study aimed to determine the oral health knowledge, practices, and status of illicit drug users at rehabilitation centers in a district in SA.Materials and Methods This was a cross-sectional study conducted at four rehabilitation centers in Pretoria, SA. Data were collected using a validated self-administered questionnaire and an oral examination. The questionnaire consisted of three parts: demographics, oral health knowledge, and oral health practices. The oral examination was conducted by a calibrated researcher and included caries, periodontal status, dental erosion, trauma, and soft tissue lesions.Statistical Analysis The data were analyzed using the Statistical Package for Social Sciences (SPSS) software.Results The mean age was 25.5 (±7.49) years with 91% being male. The majority (84%) of patients were Black, and almost all (87%) had never received oral health education; 55% were not aware that illicit drugs could have an impact on the oral health status and 40% had never had a prior dental consultation. The caries prevalence was 68% with a mean decayed, missing and filled teeth (DMFT) score of 5.3 (±6.18). More than half (58%) required periodontal treatment and there were minimal soft and hard tissue lesions diagnosed. Those who perceived their teeth to be in a poor condition had a significantly higher Decayed, Missing and Filled Teeth (DMFT) score compared with those who perceived their oral health to be good. Just under half (41.9%) of the participants did not need any periodontal intervention, with the other half presenting with plaque retention or calculus and thus needed oral hygiene intervention inclusive of scaling and polishing. There was minimal evidence of pathological oral lesions with only 1.5% presenting with necrotizing periodontal disease (NPD). Overall, there was generalized poor oral hygieneConclusion Many of the participants had poor oral hygiene knowledge and practices and a relatively high prevalence of caries. It is imperative that oral health promotion and education is incorporated into the medical interventions provided at rehabilitation centers.
Preliminary Report from a Randomized Controlled Trial Comparing Two Bovine Pericardial Valves
Authors: Sohn Suk Ho , Kim Ji Seong , Choi Jae Woong , Lee Jae Hang , Kim Jun Sung , Lim Cheong , Hwang Ho Young 
Published: August 2022

Abstract
Background A randomized controlled trial was designed to compare 1-year hemodynamic profiles and clinical outcomes after bioprosthetic aortic valve replacement (AVR) using a recently introduced (study group) and world-widely used (control group) bovine pericardial bioprostheses. This study evaluated early postoperative outcomes as a preliminary analysis.
Methods The primary end point of the trial was the mean pressure gradient across the aortic valve (AVMPG) at 1 year after surgery. Patients were screened to enroll 70 patients in each group based on a noninferiority design. Early postoperative hemodynamic and clinical outcomes were compared between the two groups.
Results There were no differences in baseline characteristics, including sex and body surface area (1.64 ± 0.18 vs. 1.65 ± 0.15 m2) between the two groups. The AVMPG on early postoperative echocardiography was 15.2 ± 4.6 mm Hg and 16.5 ± 6.2 mm Hg in the study and control groups, respectively (p = 0.177). Although AVMPG of the 19 mm prostheses was lower in the study group than in the control group (17.0 ± 6.3 mm Hg vs. 22.8 ± 6.6 mm Hg, p = 0.039), there were no significant differences in the effective orifice area in all patients (1.57 ± 0.41 cm2 vs. 1.53 ± 0.34 cm2, p = 0.568), and each valve size. The effective orifice area index was also similar between the two groups in overall (p = 0.352), and in each valve size. There were no significant differences in clinical outcomes including operative mortality and postoperative complications between the two groups.
Conclusion Early postoperative hemodynamic and clinical results after AVR using a recently introduced bovine pericardial valve were comparable with those using the control valve (NCT03796442)
Impact of Procedure Volume on the Outcomes of Surgical Aortic Valve Replacement
Authors: Oettinger Vera , Kaier Klaus , von zur Mühlen Constantin , Zehender Manfred , Bode Christoph , Beyersdorf Friedhelm , Stachon Peter , Bothe Wolfgang 
Published: August 2022

Abstract
Background Literature demonstrated that procedure volumes affect outcomes of patients undergoing transcatheter aortic valve implantation. We evaluated the outcomes of surgical aortic valve replacement.
Methods All isolated surgical aortic valve replacement procedures in Germany in 2017 were identified. Hospitals were divided into five groups from ≤25 (very low volume) until >100 (very high volume) annual procedures.
Results In 2017, 5,533 patients underwent isolated surgical aortic valve replacement. All groups were of comparable risk (logistic EuroSCORE, 5.12–4.80%) and age (66.6–68.1 years). In-hospital mortality and complication rates were lowest in the very high-volume group. Multivariable logistic regression analyses showed no significant volume–outcome relationship for in-hospital mortality, stroke, postoperative delirium, and mechanical ventilation > 48 hours. Regarding acute kidney injury, patients in the very high-volume group were at lower risk than those in the very low volume group (odds ratio [OR] = 0.53, p = 0.04). Risk factors for in-hospital mortality were previous cardiac surgery (OR = 5.75, p < 0.001), high-grade renal disease (glomerular filtration rate < 15 mL/min, OR = 5.61, p = 0.002), surgery in emergency cases (OR = 2.71, p = 0.002), and higher grade heart failure (NYHA [New York Heart Association] III/IV; OR = 1.80, p = 0.02). Risk factors for all four complication rates were atrial fibrillation and diabetes mellitus.
Conclusion Patients treated in very low volume centers (≤25 operations/year) had a similar risk regarding in-hospital mortality and most complications compared with very high-volume centers (>100 operations/year). Only in the case of acute kidney injury, very high-volume centers showed better outcomes than very low volume centers. Therefore, surgical aortic valve replacement can be performed safely independent of case volume.
Dissociative multi-ionization of N2O molecules in strong femtosecond laser field
Authors: Jiang Wenbin , Wang Xincheng , Zhang Shuai , Dong Ruichao , Guo Yuliang , Feng Jinze , Shen Zhenjie , Yan Tianmin , Zhu Zhiyuan , Jiang Yuhai 
Published: August 2022

Multi-ionization and subsequent Coulomb explosion (CE) of the N2O molecule irradiated by a linearly polarized 800 nm laser field is investigated by a reaction microscope, where a number of CE channels of N2Oq+ with q ≤ 5 for two-body fragmentation and q ≤ 8 for three-body fragmentation were observed. For two-body CE, by analyzing the internuclear separations extracted from kinetic energy releases (KERs), dissociation branching fractions, and laser intensity dependence, interestingly, we found that fragmentation N2O5+ → N3+ + NO2+ is produced directly from dissociating N2O3+ via non-sequential stairstep ionization, whereas most of the others result from the sequential stairstep ionization. For three-body CE, 25 fragmentation channels of N2Oq+ (q = 3–8) are distinguished in the present charge-encoded multi-photoion coincidence plot, and the concerted fragmentation mechanism is nominated in a typical Dalitz plot. With the help of the numerical computation with the measured KERs and momentum correlation angles, the geometric structures of molecular ions prior to fragmentation are reconstructed, which display the bending motion and simultaneous two-bond stretching before the CE. Increasing of the bond length for high charged N2Oq+ indicates the dominating stairstep ionization in the three-body fragmentation.
Delayed pressure urticaria manifesting as dyspareunia – is it that uncommon?
Authors: Konstantinou George N. , Podder Indrashis 
Published: August 2022

Delayed pressure urticaria (DPU) is a variant of physical urticaria characterised by reproducible whealing on application of sustained pressure to the skin. Clinical manifestations include delayed cutaneous erythema, edema and subcutaneous swelling, typically occurring 4–6 h after application of mechanical pressure. Dyspareunia is defined as persistent or recurrent pain in the genital area or within the pelvis that occurs just before, during, or after sexual intercourse. We report an unusual case of DPU manifesting as dyspareunia.
Performance analysis of synthetic jet micropump based on double piezoelectric actuators
Authors: Hu Dianbin , He Lipeng , Hu Renhui , Hou Yi , Liu Yamei , Cheng Guangming 
Published: August 2022

Abstract
To alleviate the problem of low flow rates of synthetic jet piezoelectric pumps for liquid medium, a double piezoelectric synthetic jet micropump (DPSJM) is proposed. DPSJM generates pressure change in the pump chamber by the high voltage vibration of the double piezoelectric actuators. Theoretical models are used to analyze the factors affecting the performance of DPSJM. The flow field is analyzed by using the finite element method in the jet chamber, and the prototype is built and tested. The results show that the performance of the DPSJM is best with double piezoelectric actuators with a sine wave drive signal and a pump chamber height of 1 mm. The highest flow rate comes to 22.11 ml min−1 at 175 V, 65 Hz. Moreover, the DPSJM is simple in construction. When compared to other types of valveless piezoelectric pumps, there was no resistance fluid in the pump chamber, which could significantly reduce the damage to the transfer medium.
Unfolding the conductivity reversal n- to p-type in phosphorus-doped ZnO thin films by spin-on dopant (SOD) process
Authors: Mishra Madhuri , Saha Rajib , Bhowmick Sangita , Pandey Sushil Kumar , Chakrabarti Subhananda 
Published: August 2022

Abstract
Phosphorus doping induced p-type doping in ZnO thin films based on spin-on dopant (SOD) process is reported in this article. Owing to the reduced dependence on the conventional amenities for diffusion/ion-implantation doping, the SOD process provides a simple and cheap doping method. The effect of SOD process temperature on conductivity ZnO thin films is investigated by altering the temperature from 700°C to 1000°C. Systematic field emission scanning electron microscopy analysis demonstrates the impact of doping temperature on the morphological properties of SOD. The x-ray diffraction measurements reveal that the p-type ZnO thin films had (002) preferred crystal orientation. At the same time, x-ray photoelectron spectroscopy validated the formation of the PZn–2VZn complex, which was responsible for the acceptor behaviour of films. Moreover, the photoluminescence spectra tracked down that the origin of 3.35 and 3.31 eV emission peaks is due to the acceptor bound exciton and free-electron to acceptor level transitions, respectively. Finally, an elevated hole concentration of 2.09 × 1016 cm−3 is achieved with a resistivity of 1.14 Ω-cm at 800°C doping temperature. However, the film doped at 900°C and 1000°C showed n-type behaviour due to the generation of high concentration donor defects. Here, we successfully demonstrate that the SOD process has great potential to produce high-quality p-type ZnO thin films suitable for optoelectronic devices applications.