bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient digitization of the Zentrum am Berg research tunnel – From laser scan to triangulated surface model within one day
Authors: Dorninger Peter , Studnicka Nikolaus 
Published: June 2022

AbstractUnthinkable just a few years ago, the precise laser‐scanning survey of a kilometer‐long tunnel in one day by one operator has become possible. This article describes how 261 scans were taken with a RIEGL VZ‐400i laser scanner to digitize the Zentrum am Berg (ZaB) research tunnel with millimeter resolution. The data has been automatically registered during the acquisition process within the instrument. After applying multistation adjustment, a block adjustment postprocess step, the high accuracy of the point cloud with respect to a network of 35 retroreflective bireflex targets has been approved. For further applications such as analysis, simulation, or visualization, a homogeneous 3D‐meshed surface model has been created automatically from the point cloud representing an as‐built 3D documentation of the tunnel.
Adaptive and parameterised 3D BIM model for the tunnel tender and excavation phase
Authors: Wenighofer Robert , Eder Nina , Speckmoser Valentin , Villeneuve Marlene , Winkler Leopold , Galler Robert 
Published: June 2022

AbstractBuilding information modelling (BIM) is a frequently discussed topic in tunnelling since it promises less loss of information and reduced lifetime cost of underground infrastructure. There is still some way to go as standardisation in this sector is immature, the implementation of three‐dimensional (3D) BIM models is developed for pilot cases of tunnelling only, and data transfer between software tools is a challenge. The long linear structures of tunnels make a specific approach of parameterised and adaptive modelling necessary to meet the requirements of repetitive construction elements and the natural differences of forecast and actual excavation conditions. This approach renders the matching of construction elements in the model and service items feasible for determining quantities for the tender and billing in tunnel projects. In this article, we show that only 57 % of service items can actually be linked to a physical item in traditional two‐dimensional (2D) design and highlight the need to consider how to incorporate these items into a BIM model. We also use a case study to propose an approach for parameterised and adaptive modelling of repetitive construction elements and show a way of a continuous data transfer from the forecast tunnelling class distribution via 3D BIM modelling to a billing software without data loss.
Translabial ultrasound evaluation after tension‐free transobturator tape technique: Outcomes based on the tape's position
Authors: Gugliotta Giorgio , Schiattarella Antonio , Giunta Margherita , De Franciscis Pasquale , Polito Salvatore , Calagna Gloria 
Published: June 2022

AbstractObjectiveThe purpose of this study was to evaluate the feasibility and accuracy of postoperative translabial ultrasound to assess the position of the tape implanted with the tension‐free transobturator tape technique.MethodsWe enrolled women with clinically and urodynamically proven type I or II stress urinary incontinence who were referred for transobturator tape treatment.ResultsA total of 50 women underwent a transobturator tape procedure and were included in the analysis. We divided the patients into two study groups (group A and group B), characterized by normal and obstructed flow at least 30 days after the surgical procedure visit, respectively. We performed a translabial ultrasound evaluation to assess the suburethral localization of the sling. On the longitudinal scan, the distance between the bladder neck and the suburethral sling was >10 mm in all patients in group A (16.7 ± 1.6). On the contrary, the values in group B were ≤10 mm (5.3 ± 4.8).ConclusionOur findings highlight the role of a skilled sonographic operator performing translabial ultrasound as a first‐line method for evaluating postoperative transobturator tape procedure and sling positioning. Moreover, translabial ultrasound could be helpful to determine a “cutoff” of the bladder neck to sling distance, as this is related to the onset of the obstruction.
The effect of magnesium sulfate on maternal serum electrolytes and parathyroid hormone in pre‐eclampsia
Authors: Farahani Masoumeh , Sharifinejad Niusha , Hashemnejad Maryam , Mashak Banafsheh , Mahboubipour Hamid , Farahani Mahnaz , Rastad Hadith , Nirouei Matineh 
Published: June 2022

AbstractObjectiveTo evaluate possible interactions of magnesium sulfate—the drug of choice in the management of pre‐eclampsia/eclampsia—in response to a few case reports that revealed maternal electrolyte disturbances, especially symptomatic changes, following magnesium sulfate administration in pre‐eclampsia.MethodsProspectively, women with pre‐eclampsia were given 4 g of intravenous magnesium sulfate followed by a 2 g/h infusion up to 24 h after delivery. Sequential blood samples were drawn from each patient and used to measure the serum levels of sodium, potassium, calcium, phosphorus, magnesium, and parathyroid hormone.ResultsA total of 30 pregnant women with pre‐eclampsia were evaluated. They were aged between 20 and 41 years with median gestational age of 37.6 (interquartile range 35.4–38.9) weeks. Only five patients reached the therapeutic window of magnesium in at least one of our measuring intervals during magnesium sulfate infusion. Plasma magnesium concentrations increased significantly during magnesium sulfate administration and dropped during the next 12 and 24 h after infusion discontinuation (P < 0.05). Fifteen of 30 (50%) patients developed asymptomatic hypocalcemia, mainly at hour 24 of infusion. Negative moderate correlations were detected between the calcium and magnesium concentrations at 12 and 24 hours of infusion (ρ = −0.390, P = 0.044 and ρ = 0.315, P = 0.096, respectively). None of the patients with hypocalcemia reached the therapeutic level of magnesium or experienced parallel hyperphosphatemia. Eleven of 30 (36.6%) patients developed hyperphosphatemia mainly at 2 and 12 h of magnesium sulfate infusion.ConclusionsOur study implies that magnesium sulfate could cause hypermagnesemia‐induced hypocalcemia in women with pre‐eclampsia, independent from parathyroid hormone. The negative correlations between calcium and magnesium concentrations could be indicative of dose‐dependent associations between serum magnesium level and degree of hypocalcemia in our study.
Tips for handling common avian and reptile pets
Authors: Sayers Ian 
Published: June 2022

Background: Exotic pets are increasingly being presented to veterinary practices. Familiarity with basic handling techniques of commonly presented species helps significantly in building client confidence and improving the client bond with the practice. Basic handling skills are integral in enabling a clinical examination, as well as being the first step in obtaining appropriate diagnostic samples. Species size can vary dramatically which will have a bearing on particular techniques used, but techniques have a degree of commonality. This article will consider handling of common pet avian and reptile species.Aim of the article: This article aims to provide handling advice for common avian and reptile pets, but not for all of the 20,000+ species that exist; for example, reference to crocodilia, venomous species, large terrestrial chelonia and large flightless birds are beyond the scope of this article.
Inside Cover
Authors: Ghimire Hemendra , Viennois Emilie , Hu Xinjie , Qin Gengsheng , Merlin Didier , Perera A. G. Unil 
Published: June 2022

Rapid, reliable, minimally invasive, and cost‐effective screening for ulcerative colitis (UC). Gold‐standard endoscopic tests are expensive, invasive, with associated risks, and are not comfortable to use, affecting compliance rates. This novel approach could provide an indication of UC encouraging them on endoscopic tests.Further details can be found in the article by Hemendra Ghimire, Emilie Viennois, Xinjie Hu, Gengsheng Qin, Didier Merlin, and A. G. Unil Perera (e202100307)image
Broad‐spectrum cytotoxicity to cancer cells of Brevilaterin C from Brevibacillus laterosporus and its specific mechanism on human epidermal cancer cells
Authors: Chen Zhou , Wang Lulu , Hong Dan , Liu Yangliu , Han Panpan , Li Siting , Jia Yingmin 
Published: June 2022

AbstractAntimicrobial peptides (AMP) from Brevibacillus laterosporus have good prospects as clinical treatments for cancer. Nevertheless, details about their anticancer spectrum and mode of cytotoxicity remain poorly understood. A newly found AMP (named Brevilaterin C) secreted by B. laterosporus S62‐9 exhibited strong inhibition on almost cancer cell lines examined at a concentration of 8 µg/ml but was relatively safe for normal cells. We further systematically examined its cytotoxicity and mechanism toward human epidermal cancer cell A431. A dosage of 3 µg/ml of Brevilaterin C could significantly increase lactate dehydrogenase release of tumor cells. Moreover, it could remarkably increase the ratio of apoptosis and reactive oxygen species generation of A431, indicating effective induction of apoptosis. Moreover, the formation of JC‐1 aggregates was effectively prevented by a low concentration of Brevilaterin C, indicating its effective induction of A431's apoptosis. Brevilaterin C exhibited broad‐spectrum cytotoxicity to cancer cells, indicating a good potential prospect in the medical field.
Elevation of neutrophil carcinoembryonic antigen‐related cell adhesion molecule 1 associated with multiple inflammatory mediators was related to different clinical stages in ischemic stroke patients
Authors: Zhang Yi , Wang Yijie , Wu Wei , Liu Ping , Sun Shanshan , Hong Meng , Yuan Yuan , Xia Qi , Chen Zhi 
Published: June 2022

AbstractBackgroundWe aimed to analyze the level of carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) in neutrophils of ischemic stroke (IS) patients at different stages, together with its roles in neutrophils.Patients and methodsSixty‐seven patients were classified into acute phase group (n = 19), subacute phase group (n = 28), and stable phase group (n = 20), and 20 healthy individuals who had received physical examination at the same time period as healthy control. We then analyzed the expression level of CEACAM1 and cell viability in CEACAM1 positive and CEACAM1 negative neutrophils by flow cytometry and the content of plasma CEACAM1, neutrophil gelatinase‐associated lipocalin (NGAL), matrix metalloproteinases‐9 (MMP‐9) was measured using enzyme‐linked immunosorbent assay (ELISA), while that of interleukin‐10 (IL‐10) and tumor necrosis factor (TNF) was determined using a Human Enhanced Sensitivity Flex set.ResultsCompared with healthy control, the percentage of CEACAM1 positive neutrophils in IS patients showed a significant increase, and a significant increase was also noticed in the content of plasma CEACAM1 at the subacute stage. Reduction in cell viability was observed in CEACAM1 positive neutrophils compared with CEACAM1 negative counterparts. There was a positive correlation between CEACAM1 expression rate in neutrophils and plasma CEACAM1 and IL‐10 content in the subacute group. Compared with acute group and healthy control group, there was an instinct increase in the level of plasma MMP‐9 and NGAL in subacute group.ConclusionsOur data showed that there was a rapid increase of CEACAM1 in neutrophils at the acute stage of IS. We speculated that CEACAM1 may serve as an inhibitory regulator involving in the progression of IS.
Design, synthesis, and antimicrobial activity of novel Isoxazolyl Imidazo[2,1‐b]Thiazole libraries
Authors: Saini Ramakrishna , Dharavath Nagaraju , Malladi Srinivas Reddy 
Published: June 2022

AbstractA simple and efficient iodine‐promoted synthesis has been developed for the synthesis of isoxazolyl aryl thiazole amines (3) from easily available isoxazolyl aryl ethanones (1) and thiourea (2) in good yields. Furthermore, isoxazolyl aryl thiazole amines (3) are utilized as building blocks for the synthesis of novel isoxazolyl imidazo[2,1‐b]thiazole libraries 6. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and Mass spectral data. The title compounds 6a‐ah were evaluated for their antimicrobial activity. Compounds 6d, 6 g, 6p, 6q, 6r, 6 s, 6u, 6v, 6w, and 6x exhibited significant antimicrobial activity as that of standard drugs.
Dynamic change of circulating innate and adaptive lymphocytes subtypes during a cascade of gastric lesions
Authors: Fu Weiwei , Wang Wenyan , zhang Jing , Zhao Yang , Chen Keyan , Wang Ye , Zhang Jing , Xiong Ying , Guo Xiaohuan , Ding Shigang 
Published: June 2022

AbstractAccording to the Correa model, the intestinal-type gastric cancer (GC) is preceded by premalignant lesions, including chronic gastritis, intestinal metaplasia and dysplasia. However, the dynamic change of innate and adaptive immune response during this process has not been studied comprehensively. In this study, we performed a comprehensive and trajectory analysis of circulating innate lymphoid cells (ILCs) and adaptive Th lymphocytes subtypes in patients spanning a cascade of gastric lesions. Increased circulating ILC2s frequency was found in the gastritis, premalignant stage and GC group, whereas further decreased ILC2s were detected in the GC group compared with the premalignant group. Moreover, ILC3s level was higher in both gastritis, premalignant lesion and GC stage, compared with healthy controls. Furthermore, up-regulated T follicular helper (Tfh) cell proportions were detected in the gastritis and premalignant process. In conclusion, by analyzing the circulating ILCs and Th cells frequency and the key cytokine production or immunoglobulin level, we demonstrated the potential involvement of ILC3 and Tfh in the gastric diseases. These findings will help to understand the immunologic mechanisms in both GC and the premalignant process and contribute to serve potential therapeutic targets to prevent the GC development.
Epidemiological characteristics of hand, foot, and mouth disease clusters during 2016–2020 in Beijing, China
Authors: Cui Yan , Yang Yan‐Na , Zheng Ran‐Ran , Xie Ming‐Zhu , Zhang Wan‐Xue , Chen Lin‐Yi , Du Juan , Yang Yang , Xi Lu , Li Hua , Li Hong‐Jun , Lu Qing‐Bin 
Published: June 2022

AbstractHand, foot, and mouth disease (HFMD) is an infectious disease that usually occurs in children under 5 years and is caused by a group of enteroviruses. This study aimed to investigate the epidemiological characteristics of HFMD clusters from 2016 to 2020 in Tongzhou, Beijing, and explored the genetic evolution of CV‐A6. The HFMD case information came from the Information System of China Center for Disease Control and Prevention (CDC), as well as the clusters information verification and on‐site investigation by Tongzhou CDC. ARIMA model was applied to forecast HFMD clusters in 2020. Totally 440 HFMD clusters were reported during 2016–2020. The large peak of the clusters occurred in April–July, followed by a smaller peak in October–November during 2016–2019. However, in 2020, the two peaks disappeared. The main site of HFMD clusters was childcare facilities (65.0%) and mostly occurred in urban areas (46.1%). The detection rate of CV‐A6 was the highest (36.1%), and cases with CV‐A6 infection had the highest proportion of fever. The phylogenetic analysis based on CV‐A6 VP1 gene showed that the predominant strains mainly located in Group F during 2016–2017, while changed into Group A during 2018–2020. HFMD clusters presented seasonality, mainly located in childcare facilities and urban areas, and CV‐A6 was the major causative agent. Targeted prevention and control measures should be taken to reduce HFMD clusters.
Antibody response three months after SARS‐CoV‐2 infection
Authors: Oktay Gültekin Efdal , Gültekin Onur , Coskun Arzu , Aksak Tiince 
Published: June 2022

AbstractThe coronavirus disease‐19 (COVID‐19) pandemic became the greatest public health challenge globally. In our study, it was aimed to determine the antibody levels in the third month after the COVID‐19 infection and the symptoms that continued until the third month from the onset of the infection. One hundred people who applied to Tarsus State Hospital with the suspicion of COVID‐19 and were positive for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection by real‐time reverse transcriptase‐polymerase chain reaction were included. We collected serum samples from individuals, who were 3 months postinfection, and tested them in anti‐SARS‐CoV‐2 Quanti‐Vac ELISA IgG kit coated with recombinant S1 antigen for testing SARS‐CoV‐2 antibodies. Antibody levels were found to be higher in those aged ≥55 years, nonsmokers, those with comorbidities, and those who were hospitalized. The four most common symptoms that individuals initially encounter; are weakness, muscle and joint pain, loss of taste and smell, and cough. In 3 months after COVID‐19 infection, the most common four symptoms are; muscle and joint pain, insomnia, fatigue, and other problems were determined. In conclusion; more research is needed to determine threshold levels of serum antibodies that could prevent reinfection of SARS‐CoV‐2.
Antibody response after two doses of homologous or heterologous SARS‐CoV‐2 vaccines in healthcare workers at health promotion centers: A prospective observational study
Authors: Nah Eun‐Hee , Cho Seon , Park Hyeran , Kim Suyoung , Noh Dongwon , Kwon Eunjoo , Cho Han‐Ik 
Published: June 2022

AbstractAssaying of anti‐spike‐protein receptor‐binding domain (S‐RBD) antibodies are used to aid evaluations of the immune statuses of individuals. The aim of this study was to determine the antibody response after two doses of homologous or heterologous severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines and to identify the factors affecting this response among healthcare workers (HCWs) at health promotion centers. In this prospective observational study, 1095 consenting HCWs were recruited from 16 health checkup centers and were tested at T0 (day of first dose), T1‐1 (1 month after first dose), T2‐0 (day of second dose), T2‐1 (1 month after second dose), and T2‐3 (3 months after second dose). SARS‐CoV‐2 antibodies were measured using a chemiluminescence microparticle immunoassay with SARS‐CoV‐2 IgG II Quant in the ARCHITECT system (Abbott Diagnostics). At T1‐1, anti‐SARS‐CoV‐2 S‐RBD IgG levels were significantly higher in participants who received messenger RNA (mRNA) vaccines than in those who received viral vector vaccines (p < 0.001). At T2‐1, anti‐SARS‐CoV‐2 S‐RBD IgG levels were about 10 times higher than at T1‐1 in participants who received homologous mRNA vaccines, which decreased to a third of those at T2‐3. Anti‐SARS‐CoV‐2 S‐RBD IgG levels were highest among those who received homologous mRNA vaccines, followed by heterologous mRNA viral vector vaccines and homologous viral vector vaccines at T2‐3 (p < 0.001). In a multivariable linear regression analysis, being female, taking at least one mRNA vaccine, and having a history of recovery from coronavirus disease 2019 (COVID‐19) were significantly associated with anti‐S‐RBD levels. Anti‐SARS‐CoV‐2 S‐RBD IgG levels were decreased at 3 months after two‐dose vaccinations and were associated with sex, vaccine type, and COVID‐19 history.
The clinical and bioinformatics analysis for the role of antihypertension drugs on mortality among patients with hypertension hospitalized with COVID‐19
Authors: Zhao Liyang , Li Yusi , Yi Wenjuan , Yan Kuo , Yang Chao , Radhakrishnan Sridhar , Li Rui , Tan Ruirong , Fan Gang , Dai Mengyuan , Liu Miao , Shao Ning‐Yi 
Published: June 2022

AbstractComorbidities such as hypertension could exacerbate symptoms of coronaviral disease 2019 (COVID)‐19 infection. Patients with hypertension may receive both anti‐COVID‐19 and antihypertension therapies when infected with COVID‐19. However, it is not clear how different classes of anti‐hypertension drugs impact the outcome of COVID‐19 treatment. Herein, we explore the association between the inpatient use of different classes of anti‐hypertension drugs and mortality among patients with hypertension hospitalized with COVID‐19. We totally collected data from 278 patients with hypertension diagnosed with COVID‐19 admitted to hospitals in Wuhan from February 1 to April 1, 2020. A retrospective study was conducted and single‐cell RNA‐sequencing (RNA‐Seq) analysis of treatment‐related genes was performed. The results showed that Angiotensin II receptor blocker (ARB) and calcium channel blocker (CCB) drugs significantly increased the survival rate but the use of angiotensin‐converting enzyme inhibitor/β‐block/diuretic drugs did not affect the mortality caused by COVID‐19. Based on the analysis of four public data sets of single‐cell RNA‐Seq on COVID‐19 patients, we concluded that JUN, LST1 genes may play a role in the effect of ARB on COVID‐19‐related mortality, whereas CALM1 gene may contribute to the effect of CCB on COVID‐19‐related mortality. Our results provide guidance on the selection of antihypertension drugs for hypertensive patients infected with COVID‐19.
Steerable versus nonsteerable sheath technology in atrial fibrillation ablation: A systematic review and meta‐analysis
Authors: Mhanna Mohammed , Beran Azizullah , Al‐Abdouh Ahmad , Sajdeya Omar , Barbarawi Mahmoud , Alsaiqali Mahmoud , Jabri Ahmad , Al‐Aaraj Ahmad , Alharbi Abdulmajeed , Chacko Paul 
Published: June 2022

AbstractIntroductionCatheter placement and stability are well‐known challenges in atrial fibrillation (AF) ablation. As a result, steerable sheaths (SS) were developed to improve catheter stabilization and maintain proper catheter–tissue contact. The purpose of this systematic review and meta‐analysis is to see if employing a SS influences procedure outcome.MethodWe performed a comprehensive literature search for studies that evaluated the efficacy and safety of SS compared to nonsteerable sheaths (NSS) in AF ablation. The primary outcome was the rate of atrial arrhythmia (AA) freedom by the time of the last follow‐up. The secondary outcomes were the procedure‐related complications and procedural characteristics. Risk ratio (RR) or the mean difference (MD) and corresponding 95% confidence intervals (CIs) were calculated using the random‐effects model.ResultsA total of 10 studies, including 967 AF patients (mean age: 59.2 ± 11.1 years, 516 patients managed with SS vs. 454 with NSS), were included. SS group showed a higher rate of freedom of AA compared to NSS (RR: 1.19; 95% CI 1.09–1.29; p < .001). Both techniques had similar rate for procedural‐related complication (RR: 1.09, 95% CI 0.50–2.39; p = .83). The SS strategy had a shorter procedure time (MD −10.6 [min], 95% CI −20.97, −0.20; p = .05) but comparable fluoroscopic and radiofrequency application times to the NSS group.ConclusionsThe SS for AF catheter ablation not only reduced the total procedure time but also significantly increased the rate of successful ablation while maintaining a similar safety profile when compared to the traditional NSS.