bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective Cardiovascular Surveillance of Immune Checkpoint Inhibitor–Based Combination Therapy in Patients With Advanced Renal Cell Cancer: Data From the Phase III JAVELIN Renal 101 Trial
Authors: Rini Brian I. , Moslehi Javid J. , Bonaca Marc , Schmidinger Manuela , Albiges Laurence , Choueiri Toni K. , Motzer Robert J. , Atkins Michael B. , Haanen John , Mariani Mariangela , Wang Jing , Hariharan Subramanian , Larkin James 
Published: March 2022

PURPOSE Both immune checkpoint inhibitors (ICIs) and vascular endothelial growth factor receptor (VEGFR) inhibitors are approved for advanced renal cell carcinoma treatment and can cause cardiovascular events (CVs); thus, combination therapy could lead to major adverse CV events (MACE). Cardiac serum biomarker assessment and imaging, including left ventricular ejection fraction (LVEF) monitoring, can be used to evaluate MACE. METHODS To our knowledge, the JAVELIN Renal 101 trial, assessing avelumab plus axitinib versus sunitinib in patients with advanced renal cell carcinoma, is the first randomized study of ICI plus VEGFR inhibitor treatment to include prospective serial cardiac monitoring of LVEF and serum cardiac biomarkers. RESULTS MACE (defined as grade ≥ 3 CV AEs) occurred in 31 patients (7.1%) in the combination arm and 17 patients (3.9%) in the sunitinib arm. Patients in the combination arm who had high baseline troponin T values were at higher risk of MACE versus patients with low values (MACE in 6/35 v 7/135, respectively; relative risk, 3.31; 95% CI, 1.19 to 9.22). This association was not observed in patients treated with sunitinib. Other CV baseline risk factors and serum cardiac biomarkers were not significantly predictive for MACE, although a trend toward an association with dyslipidemia was seen in the combination arm. No clinical value of on-treatment routine monitoring of LVEF in relation to MACE was observed. Although LVEF decline was significantly more frequent in the combination arm, most patients recovered, and decline was not associated with other significant cardiac events or symptoms. CONCLUSION Patients with high baseline troponin T levels receiving ICI and VEGFR combinations may need to be monitored more closely for MACE. Routine monitoring of LVEF in asymptomatic patients is not recommended.
Long or Irregular Menstrual Cycles and Risk of Prevalent and Incident Nonalcoholic Fatty Liver Disease
Authors: Cho In Young , Chang Yoosoo , Kang Jae-Heon , Kim Yejin , Sung Eunju , Shin Hocheol , Wild Sarah H , Byrne Christopher D , Ryu Seungho 
Published: March 2022

Abstract

Context
The association of menstrual cycle length and irregularity with the risk of non-alcoholic fatty liver disease (NAFLD) is unknown.

Objective
We examined this association in large cross-sectional and cohort studies.

Methods
The cross-sectional study included 72 092 women younger than 40 years who underwent routine health examinations; the longitudinal analysis included the subset of 51 118 women without NAFLD at baseline. Long or irregular cycles were defined as menstrual cycles of 40 days or longer or too irregular to estimate. Abdominal ultrasonography was performed to identify NAFLD. Multivariable Cox proportional hazard regression analyses were performed to estimate hazard ratios (HRs) and 95% CIs for incident NAFLD according to menstrual cycle regularity and length, with 26- to 30-day cycles as the reference.

Results
At baseline, 27.7% had long or irregular menstrual cycles and 7.1% had prevalent NAFLD. Long or irregular menstrual cycles were positively associated with prevalent NAFLD. During a median follow-up of 4.4 years, incident NAFLD occurred in 8.9% of women. After adjustment for age, body mass index, insulin resistance, and other confounders, the multivariable-adjusted HR for NAFLD comparing long or irregular menstrual cycles to the reference group was 1.22 (95% CI, 1.14-1.31); this association strengthened in the time-dependent analysis with an HR of 1.49 (95% CI, 1.38-1.60).

Conclusion
Long or irregular menstrual cycles were associated with increased risk of both prevalent and incident NAFLD in young, premenopausal women. Women with long or irregular menstrual cycles may benefit from lifestyle modification advice to reduce the risk of NAFLD and associated cardiometabolic diseases.
Shakespeare “Translated and Improved”: The Translational Politics of the American Yiddish Theater and Its Afterlife
Authors: Luzon Danny 
Published: March 2022

Abstract
This article explores the American Yiddish theater’s creative reworkings of William Shakespeare, a practice epitomized by the presumed parodic dictum “translated and improved” (fartaytsht un farbessert). It argues that this theater’s translational politics of chutzpah strives to breach fixed literary and familial lineages by treating the high-canonical Anglo text as a porous space, open to endless cultural attachments. Through revisionary acts of intercultural exchange, the Yiddish theater and its followers envision literary inheritance as something that is not bounded by familial descent and dissent but rather is open to alternative modes of kinship. Specifically, this late nineteenth-century strategy is carried forward by authors such as Anzia Yezierska and Grace Paley, who turn to the Yiddish theater’s proclaimed improvement of Shakespeare in their multilingual English works in order to envision a radical fluidity of the American self. Writing on the periphery of US literary production, the authors studied in this article Judaize, Yiddishize, and queer Shakespearean characters, insisting on both the semantic and semiotic ways in which translations can democratize the linguistic economy of Anglo-American literature.
Eleven Kinds? Loneliness and Reading for Type with Richard Yates
Authors: Reese Sam V. H. 
Published: March 2022

Abstract
During the mid-twentieth century, loneliness became the dominant affect in American fiction, reflecting a broader cultural narrative that social and demographic changes had led to a crisis of loneliness. This affective shift is captured in Richard Yates’s 1962 short story collection, Eleven Kinds of Loneliness—but Yates’s deliberate framing of his stories as “eleven kinds” implies a second object of critique. Reading Yates’s work for social and psychological types, this article proposes that personality tests, corporate typing, and social typologies had a major role in the rise in loneliness in midcentury America—a relationship borne out by contemporary sociology, most prominently The Lonely Crowd (1950) by David Riesman, Nathan Glazer, and Reuel Denney. This article further argues that by reading midcentury fiction more broadly for type, we can understand loneliness not merely as a bad feeling but as a space of contest between individuality and group belonging, intimately connected to larger political and social narratives. Setting Yates’s stories against midcentury novels by Ralph Ellison and Mary McCarthy, this article reframes American loneliness in light of the cultural changes of the midcentury and writers’ struggles with the possibilities and limitations of type.
Rape and Mutiny at Fort Jackson: Black Laundresses Testify in Civil War Louisiana
Authors: Feimster Crystal N. 
Published: March 2022

Abstract
The Black soldiers of the Fourth Regiment of the Native Guard (also known as the Corps d'Afrique) stationed at Fort Jackson, Louisiana, and the laundresses who served them and their white officers were formerly enslaved people who had seized their freedom by joining and aiding the Union cause. Over the course of six weeks, in December 1863 and January 1864, they engaged in open munity to protest racial and sexual violence inflicted by white Union officers. In so doing they made visible the violent terms of interracial interaction that informed the meaning of wartime freedom and Black labor (terms that were still very much rooted in the prisms and discourses of enslavement). More importantly, as free labor Black women began to negotiate a deeply abusive racial and sexual terrain.
A Simple Method for Foramen Ovale Puncture Based on Preoperative Image Simulation in Percutaneous Microcompression of the Trigeminal Ganglion
Authors: Guo Wenchang , Shi Haowei , Wen Xiaolong , Qian Tao 
Published: March 2022

BACKGROUND:
The classic puncture method of percutaneous microcompression using fluoroscopy might be difficult to precisely locate and visualize the foramen ovale. Various new surgical tools to increase the accuracy of finding the foramen ovale location have been introduced. However, all of these systems require some complicated operating steps and/or advanced devices to complete the work.

OBJECTIVE:
To describe the use of a simple method for foramen ovale puncture by percutaneous microcompression based on preoperative image simulation.

METHODS:
Forty-five patients were included in the study. All patients underwent a computed tomography examination. Among them, the simulated preoperative puncture pathway was reconstructed on the basis of computed tomography scan examination for 22 patients. Procedures were performed by 2 surgeons: one experienced surgeon and another young surgeon with surgical qualification. The puncturing time and cumulative radiation exposure dose, from start of the puncturing until reaching the foramen ovale, were recorded. Postoperative pain relief, facial hypoesthesia, masticatory muscle weakness, and other complications were recorded.

RESULTS:
In all cases, the procedure of cannulation was completed successfully. The puncturing time for both the experienced and young surgeon with the use of preoperative image simulation seemed to be time-saving. The young surgeon had less cumulative radiation exposure with the use of preoperative image simulation. Moreover, the intraoperative puncture pathways were almost consistent with the preoperative simulated images. The rest of the process went smoothly. Short-term outcomes of all the 45 patients were satisfactory.

CONCLUSION:
Based on our preliminary experience, the preoperative image simulation–guided technique is useful during these cases.
Characterising processes and outcomes of tailoring implementation strategies in healthcare: a protocol for a scoping review
Authors: Riordan Fiona , Curran Geoffrey M. , Lewis Cara C. , Powell Byron J. , Presseau Justin , Wolfenden Luke , McHugh Sheena M. 
Published: March 2022

Background: Tailoring strategies to target the salient barriers to and enablers of implementation is considered a critical step in supporting successful delivery of evidence based interventions in healthcare. Theory, evidence, and stakeholder engagement are considered key ingredients in the process however, these ingredients can be combined in different ways. There is no consensus on the definition of tailoring or single method for tailoring strategies to optimize impact, ensure transparency, and facilitate replication. Aim: The purpose of this scoping review is to describe how tailoring has been undertaken within healthcare to answer questions about how it has been conceptualised, described, and conducted in practice, and to identify research gaps. Methods: The review will be conducted in accordance with best practice guidelines and the Preferred Reporting Items for Systematic Reviews and Meta-analysis extension for scoping reviews (PRISMA-ScR) will be used to guide the reporting. Searches will be conducted of MEDLINE, Embase, Web of Science, Scopus, from 2005 to present. Reference lists of included articles will be searched. Grey literature will be searched on Google Scholar. Screening and data extraction will be conducted by two or more members of the research team, with any discrepancies resolved by consensus discussion with a third reviewer. Initial analysis will be quantitative involving a descriptive numerical summary of the characteristics of the studies and the tailoring process. Qualitative content analysis aligned to the research questions will also be conducted, and data managed using NVivo where applicable. This scoping review is pre-registered with the Open Science Framework. Conclusions: The findings will serve a resource for implementation researchers and practitioners to guide future research in this field and facilitate systematic, transparent, and replicable development of tailored implementation strategies.
KNOWLEDGE MANAGEMENT AS AN INTEGRAL COMPONENT OF PERSONNEL DEVELOPMENT
Authors: Galynchik Tatyana A. , Gasnikova Svetlana Yu. 
Published: March 2022

In the digital economy, one of the priorities of the personnel strategy is the direction of investments in personnel to gain new knowledge and relevant professional competencies. Today, organizations need employees who are able to use and maintain the information technologies introduced into the business.
Digitalization and the formation of the information society dictates new conditions for the competencies of personnel. In order to maintain competitiveness, the organization is forced to ensure the development of digital competencies of personnel. Knowledge management should provide continuous education, self-learning, adaptability to changing conditions, the ability to work in different teams, critical thinking, the desire for new things and the search for innovations.
The aim is to study the impact of knowledge management on staff development due to the transition to the digital economy.
Method of work: the article used general scientific methods, approaches and techniques, such as monographic, abstract-logical, comparison, qualitative analysis, etc.
Results of the work: this article draws attention to how the changes associated with the digitalization of the economy directly affect the issues of personnel knowledge management. It is concluded that the introduction of principles and approaches of knowledge management is required for the development of personnel in modern conditions.
Scope of the results: the results obtained will be useful to organizations when developing personnel development programs through knowledge management in the context of digitalization.
Reference Dependence in Intertemporal Preference
Authors: Li Zhihua , Zhong Songfa 
Published: March 2022

Dynamic structures in intertemporal choices offer multiple channels through which reference dependence can occur. We examine intertemporal reference dependence when using choice lists to elicit time preference over outcome sequences. Reference point effects can arise endogenously within an outcome sequence and exogenously from the experimental environment of the choice list. We show that estimated discount factors in the choice list are biased by both kinds of reference points and propose a model to jointly account for both. Our experimental design with outcome sequences also enables us to jointly estimate the discount factor and utility curvature. We further discuss the implications for recent developments in the measurement of intertemporal preference. This paper was accepted by Manel Baucells, behavioral economics and decision analysis. Funding: S. Zhong was supported by the National University of Singapore [Singapore Ministry of Education Academic Research Fund Tier 1 Grant R-122-000-325-115]. Supplemental Material: The data files and online appendices are available at https://doi.org/10.1287/mnsc.2022.4348 .
Does negative pressure wound therapy reduce the odds of infection and improve health-related quality of life in patients with open fractures?
Authors: Atwan Yousif , Sprague Sheila , Slobogean Gerard P. , Bzovsky Sofia , Jeray Kyle J. , Petrisor Brad , Bhandari Mohit , Schemitsch Emil ,   on behalf of the FLOW Investigators
Published: March 2022

Aims To evaluate the impact of negative pressure wound therapy (NPWT) on the odds of having deep infections and health-related quality of life (HRQoL) following open fractures. Methods Patients from the Fluid Lavage in Open Fracture Wounds (FLOW) trial with Gustilo-Anderson grade II or III open fractures within the lower limb were included in this secondary analysis. Using mixed effects logistic regression, we assessed the impact of NPWT on deep wound infection requiring surgical intervention within 12 months post-injury. Using multilevel model analyses, we evaluated the impact of NPWT on the Physical Component Summary (PCS) of the 12-Item Short-Form Health Survey (SF-12) at 12 months post-injury. Results After applying inverse probability treatment weighting to adjust for the influence of injury characteristics on type of dressing used, 1,322 participants were assessed. The odds of developing a deep infection requiring operative management within 12 months of initial surgery was 4.52-times higher in patients who received NPWT compared to those who received a standard wound dressing (95% confidence interval (CI) 1.84 to 11.12; p = 0.001). Overall, 1,040 participants were included in our HRQoL analysis, and those treated with NPWT had statistically significantly lower mean SF-12 PCS post-fracture (p < 0.001). These differences did not reach the minimally important difference for the SF-12 PCS. Conclusion Our analysis found that patients treated with NPWT had higher odds of developing a deep infection requiring operative management within 12 months post-fracture. Due to possible residual confounding with the worst cases being treated with NPWT, we are unable to determine if NPWT has a negative effect or is simply a marker of worse injuries or poor access to early soft-tissue coverage. Regardless, our results suggest that the use of this treatment requires further evaluation. Cite this article: Bone Jt Open 2022;3(3):189–195.
Method for developing and using high quality reference images to evaluate tone mapping operators
Authors: Mehmood Imran , Liu Xiaoxuan , Khan Muhammad Usman , Luo Ming Ronnier 
Published: March 2022

With the advancement of imaging technology, high dynamic range (HDR)
images can now be captured and displayed to produce realistic effects.
Tone mapping operators (TMOs) are used to map HDR radiance to the
displayable range. A reliable TMO would play a significant role in the
accurate reproduction of HDR scenes. The present study aimed to
establish an image quality metric based on external references to
evaluate various TMOs. Two psychophysical experiments were conducted
to develop reference images and to investigate the performance of
TMOs. In experiment 1, a set of high quality reference images was
developed by rendering image features in terms of contrast, sharpness,
and colorfulness, to achieve good rendering for each image. The images
were used as reference in experiment 2 to evaluate the performance of
14 TMOs using a six-point categorical judgment method. The TMOs were
evaluated using four scales, i.e., contrast, sharpness, colorfulness,
and overall performance. The hierarchical relationship among TMOs was
established. The results were further compared with previous studies,
and high correlation was found between the current experiments and
previous studies.
Sero-epidemiological survey of Coxiella burnetii in livestock and humans in Tana River and Garissa counties in Kenya
Authors: Mwololo Damaris , Nthiwa Daniel , Kitala Philip , Abuom Tequiero , Wainaina Martin , Kairu-Wanyoike Salome , Lindahl Johanna F. , Ontiri Enoch , Bukachi Salome , Njeru Ian , Karanja Joan , Sang Rosemary , Grace Delia , Bett Bernard 
Published: March 2022

Background
Coxiella burnetii is a widely distributed pathogen, but data on its epidemiology in livestock, and human populations remain scanty, especially in developing countries such as Kenya. We used the One Health approach to estimate the seroprevalance of C. burnetii in cattle, sheep, goats and human populations in Tana River county, and in humans in Garissa county, Kenya. We also identified potential determinants of exposure among these hosts.

Methods
Data were collected through a cross-sectional study. Serum samples were taken from 2,727 animals (466 cattle, 1,333 goats, and 928 sheep) and 974 humans and screened for Phase I/II IgG antibodies against C. burnetii using enzyme-linked immunosorbent assay (ELISA). Data on potential factors associated with animal and human exposure were collected using a structured questionnaire. Multivariable analyses were performed with households as a random effect to adjust for the within-household correlation of C. burnetii exposure among animals and humans, respectively.

Results
The overall apparent seroprevalence estimates of C. burnetii in livestock and humans were 12.80% (95% confidence interval [CI]: 11.57–14.11) and 24.44% (95% CI: 21.77–27.26), respectively. In livestock, the seroprevalence differed significantly by species (p < 0.01). The highest seroprevalence estimates were observed in goats (15.22%, 95% CI: 13.34-17.27) and sheep (14.22%, 95% CI: 12.04–16.64) while cattle (3.00%, 95% CI: 1.65–4.99) had the lowest seroprevalence. Herd-level seropositivity of C. burnetii in livestock was not positively associated with human exposure. Multivariable results showed that female animals had higher odds of seropositivity for C. burnetii than males, while for animal age groups, adult animals had higher odds of seropositivity than calves, kids or lambs. For livestock species, both sheep and goats had significantly higher odds of seropositivity than cattle. In human populations, men had a significantly higher odds of testing positive for C. burnetii than women.

Conclusions
This study provides evidence of livestock and human exposure to C. burnetii which could have serious economic implications on livestock production and impact on human health. These results also highlight the need to establish active surveillance in the study area to reduce the disease burden associated with this pathogen.