bluuebunny/crossref_metadata_2025_split huggingface dataset:
A phase III clinical trial evaluating efficacy and safety of minimal residual disease-based risk stratification for children with acute myeloid leukemia, incorporating a randomized study of gemtuzumab ozogamicin in combination with post-induction chemotherapy for non-low-risk patients (JPLSG-AML-20)
Authors: Tomizawa Daisuke , Tsujimoto Shin-ichi , Tanaka Shiro , Matsubayashi Jun , Aoki Takahiro , Iwamoto Shotaro , Hasegawa Daisuke , Nagai Kozo , Nakashima Kentaro , Kawaguchi Koji , Deguchi Takao , Kiyokawa Nobutaka , Ohki Kentaro , Hiramatsu Hidefumi , Shiba Norio , Terui Kiminori , Saito Akiko Moriya , Kato Motohiro , Taga Takashi , Koshinaga Tsugumichi , Adachi Souichi 
Published: July 2022

Abstract
The purpose of this study is to establish a treatment with appropriate intensity for children (&lt;16 years old at diagnosis) with de novo acute myeloid leukemia (excluding acute promyelocytic leukemia and myeloid leukemia associated with Down syndrome) according to a risk stratification based on recurrent leukemic cytogenetic abnormalities and flow-cytometric minimal residual disease at end of initial induction chemotherapy and to validate the safety and efficacy of gemtuzumab ozogamicin (GO)-combined post-induction chemotherapy for the non-low-risk (non-LR) patients. The primary endpoint of this phase III study is three-year disease-free survival rate, which will be compared between the GO and non-GO arms of the non-LR (intermediate-risk and high-risk [HR]) patients. All HR patients will be allocated to allogeneic hematopoietic stem cell transplantation in first remission. This trial has been registered at the Japan Registry of Clinical Trials (jRCTs041210015).
The Unintended Consequences of Welfare Reforms: Universal Credit, Financial Insecurity, and Crime
Authors: d’Este Rocco , Harvey Alex 
Published: July 2022

Abstract
We evaluate the unintended effects of Universal Credit (UC), a monumental welfare reform that has increased the stringency of the UK social security payment system. We exploit the rollout of UC across constituencies, targeting first-time claimants, predominantly young males. Using monthly data from 2010 to 2019 for England and Wales, we first document the negative economic impacts of UC, showing it has led to an increase of around 6000 repossession orders from the social housing sector. We then focus on UC’s criminogenic effects, finding the reform has caused around 35,000 burglaries and 25,000 vehicle crimes. Collectively, our findings highlight the danger of welfare policies affecting the economic incentives of individuals at the bottom of the income distribution. They also have timely policy relevance considering 6.5 million benefit recipients will soon transition onto UC. (JEL K14, K42).
Impact of Label Restriction on Checkpoint-Inhibitor Use in Bladder Cancer and Changes in Mortality
Authors: Vader Daniel T , Parikh Ravi B , Li Haojie , Imai Kentaro , Hubbard Rebecca A , Mamtani Ronac 
Published: July 2022

Abstract
In 2018, the US Food and Drug Administration (FDA) limited the indication for immune checkpoint inhibitors (ICI) in metastatic bladder cancer to patients with programmed cell death protein ligand-1 (PD-L1)–positive tumors. The impact of the label change on survival outcomes remains unknown. We conducted a controlled interrupted time series analysis using a nationwide electronic health record–derived oncology dataset. We used Cox regression to compare mortality in the post- vs prelabel change periods among affected (initiators of ICI or carboplatin-based chemotherapy) vs unaffected (initiators of cisplatin-based chemotherapy) patients. The use of ICI, carboplatin, and cisplatin was similar pre- and postlabel change, but PD-L1 testing increased postlabel change. In adjusted models, survival did not differ after the FDA label change policy compared with prior to the label change in any of the groups. The FDA label restriction on immunotherapy was associated with increased PD-L1 testing but not with changes in treatment patterns or mortality among patients with metastatic bladder cancer.
A Cognitive Bias for Zipfian Distributions? Uniform Distributions Become More Skewed via Cultural Transmission
Authors: Shufaniya Amir , Arnon Inbal 
Published: July 2022

Abstract
There is growing evidence that cognitive biases play a role in shaping language structure. Here, we ask whether such biases could contribute to the propensity of Zipfian word-frequency distributions in language, one of the striking commonalities between languages. Recent theoretical accounts and experimental findings suggest that such distributions provide a facilitative environment for word learning and segmentation. However, it remains unclear whether the advantage found in the laboratory reflects prior linguistic experience with such distributions or a cognitive preference for them. To explore this, we used an iterated learning paradigm—which can be used to reveal weak individual biases that are amplified overtime—to see if learners change a uniform input distribution to make it more skewed via cultural transmission. In the first study, we show that speakers are biased to produce skewed word distributions in telling a novel story. In the second study, we ask if this bias leads to a shift from uniform distributions towards more skewed ones using an iterated learning design. We exposed the first learner to a story where six nonce words appeared equally often, and asked them to re-tell it. Their output served as input for the next learner, and so on for a chain of ten learners (or ‘generations’). Over time, word distributions became more skewed (as measured by lower levels of word entropy). The third study asked if the shift will be less pronounced when lexical access was made easier (by reminding participants of the novel word forms), but this did not have a significant effect on entropy reduction. These findings are consistent with a cognitive bias for skewed distributions that gets amplified over time and support the role of entropy minimization in the emergence of Zipfian distributions.
Itrifal-e-Aftimoon potentiates imatinib-induced anti-leukemic effect by influencing FAK/STAT/Akt/ERK signalling pathways against chronic myeloid leukaemia in vitro
Authors: Gupta Nidhi , Nafees Sana , Rahman Aziz Ur , Akhtar Jamal , Khan Asim Ali , Sharma Alpana 
Published: July 2022

Abstract

Objectives
Limited treatment options are available for advanced stages of chronic myeloid leukaemia (CML). Moreover, patients’ relapse after a short remission period, which prompts them to identify a potent drug with the least toxicity. An Unani herbal formulation, Itrifal-e-Aftimoon (IEA) is used for certain neurological disorders, however, its antitumor potential has not been reported yet in any malignancy, including CML.

Methods
The aqueous extract of IEA was characterized by HPLC/LC-MS and used alone or in combination with standard drug, imatinib in CML cell lines (K562, KU812) in vitro to assess its effect on cancer-associated parameters such as cytotoxicity, cell cycle, apoptosis, oxidative stress, inflammation, angiogenesis, and certain signalling pathways.

Results
LC–MS characterization of IEA showed the presence of antitumor compounds including catechin and caffeic acid. Treatment with IEA caused cytotoxicity and arrested cells in the sub-G0/G1 phase. Subsequent assays confirmed apoptosis-mediated cell death with mitochondrial membrane depolarization and alleviation of oxidative stress. IEA abrogates IL-6, VEGF, angiopoietin-2, and alters Th1/Th2 cytokines. IEA potentiated the effect of imatinib even at lower doses by affecting FAK/STAT/Akt/ERK pathways.

Conclusion
IEA possesses antitumor potential against CML and increases the efficacy of imatinib when used in combination, suggesting utilization of IEA as an adjuvant therapy for better management of CML in the future.
‘A Library of Our Own Compositions’: The Minervian Library and Children’s Social Authorship in Victorian Orkney
Authors: Gleadle Kathryn , Rodgers Beth 
Published: July 2022

Abstract
This article examines the Minervian Library, an extraordinary collection of children’s manuscript stories produced in mid-Victorian Orkney. Established in 1866 by sisters Mary and Clara Cowan and their cousin Isabella Bremner, the collaborative project had ambitions beyond its beginnings as a family literary endeavour: the girls envisaged a working library complete with membership and borrowing records. On offer to the ‘Library Damsels of the Minervian Library’, as they dubbed their members, were 50 of their own original compositions, mostly comprising fairy tales, domestic dramas, and stories of European nobility. In this article, we argue that an analysis of these manuscripts and the social networks in which they were produced and circulated challenges our understanding of literary juvenilia and its relationship to wider cultural processes. We posit that the manuscripts offer a striking example of juvenile ‘social authorship’, not only in the sense of their circulation among a community of readers, but also in the ways that the authors actively engaged with developing literary trends, such as the emergence of the European literary fairy tale, and responded to contemporary debates about girlhood and girls’ lives. In this way, the Minervian Library demonstrates that children were not simply passive consumers of cultural activities, but could also be participants in the creation of collective meanings and discourses.
Bringing state capacity into the debate: a key for energy transition in emerging economy
Authors: Winanti Poppy S , Mas’udi Wawan 
Published: July 2022

Abstract
As energy consumption increases, adopting an energy transition policy has significantly intensified. The existing literature mainly argues that energy transition’s success entails ‘energy democracy’, which integrates social justice and economic equity with renewable transitions. Even though energy democracy has its merit in ensuring the energy transition, it ignores state capacity, especially in emerging economies where the state actors play a vital role in managing resources. By bringing state capacity into the discussion, this article offers a more comprehensive theoretical and empirical contribution to the current debate on energy transition in emerging economies like Indonesia. A country characterized by fragmented actors and competing interests in every arena of policies and level of governance. Therefore, in emerging economies, energy transition requires a ‘socio-technical capacity’ and ‘community engagement’—as proposed by energy-democracy theory—and the rigorous state’s capacity to make the transitions possible.
Same text, same discourse? Empirical validation of a discourse analysis methodology for cultural heritage
Authors: Martin-Rodilla Patricia , Gonzalez-Perez Cesar 
Published: July 2022

AbstractMost of the new knowledge about our past that is generated in cultural heritage disciplines is produced in non-structured forms, such as project reports, monographs, or research papers. This proliferation of cultural heritage knowledge in textual discourse form requires support for information structuration and extraction of the semantic relations embedded in these texts, in order to fully understand and post-process them. Previous works show that discourse analysis techniques can represent pieces of textual information in a highly structured manner, identifying the semantic relations between them and the entities referred to in the discourse according to well-established linguistic patterns. This is particularly useful for aligning the structure and information extracted with information system post-processing techniques, such as natural language processing, that are currently applied to cultural heritage. In this paper, we apply discourse models through a previously developed methodology to a real case study to represent and analyse cultural heritage textual narratives. Then, we perform an empirical study with cultural heritage experts in order to validate the models obtained, the resultant information, some usability aspects of the approach, and the degree of agreement between experts. The main objective was to obtain empirical and quantitative validation of the application of our proposed discourse analysis methodology to narratives in cultural heritage, its implications for different specialists, and its possibilities as a methodology to assist in providing structure to and capturing the semantics of freestyle documents, to automatize some discourse information extraction tasks and to facilitate their post-processing.
Serum Hormone Concentrations and Body Composition in Brazilian Air Force Cadets During Rainforest Survival Training
Authors: Magraner José Maurício Paixão Dos Santos , Talarico Neto Thomaz , Hahns Júnior Higino Carlos , Tourinho Filho Hugo , Martinelli Júnior Carlos Eduardo 
Published: July 2022

ABSTRACT

Background
Physiological adaptations in military jungle survival training have not yet been studied. Knowledge about the relationship between the insulin-like growth factor type I (IGF-I)/insulin-like growth factor binding protein type 3 (IGFBP-3) system and survival activities in a jungle environment can improve readiness and prepare Brazilian Air Force cadets for this kind of battlefield. Our goal was to assess changes in body composition and serum concentrations of the IGF-I/IGFBP-3 system in Brazilian Air Force cadets during five-day Amazon rainforest survival training and whether differences in sex influence these variations.

Methods
In the five-day survival training, variations in body composition and serum levels of IGF-I and IGFBP-3 were observed. The sample consisted of 14 male cadets (21.71 ± 1.64 years) and 6 female cadets (22.00 ± 1.41 years). Changes were assessed before and immediately after the survival training.

Results
The male cadets’ body mass (pre: 73.89 ± 8.79 kg; post: 69.57 ± 8.44 kg), body fat (pre: 11.43 ± 4.15%; post: 10.16 ± 4.19%), IGF-I serum concentrations (pre: 252 ± 72 ng/mL; post: 140 ± 42 ng/mL), and IGFBP-3 serum concentrations (pre: 4.90 ± 0.67 ng/mL; post: 4.22 ± 0.73 ng/mL) were significantly reduced (P &lt; .01). In the female cadets, the mean body mass values (pre: 60.98 ± 8.82 kg; post: 57.91 ± 9.01 kg), body fat (pre: 19.20 ± 5.03%; post: 17.19 ± 4.77%), and IGF-I serum concentrations (pre: 202 ± 50 ng/mL; post: 108 ± 29 ng/mL) also decreased significantly (P &lt; .01) after survival training. Finally, the cadet’s sex does not affect the variations of IGF-I (P = .46) and IGFBP-3 (P = .205) serum concentrations.

Conclusions
These findings all suggest that changes in body mass and body fat, as well as variations in the IGF-I/IGFBP-3 system, corroborate the need for military readiness preparation. Equivalent changes in both sexes indicate probable equal recovery intervals after survival training.
A Comprehensive, Multidisciplinary Assessment for Knee Osteoarthritis Following Traumatic Unilateral Lower Limb Loss in Service Members
Authors: Wasser Joseph G , Hendershot Brad D , Acasio Julian C , Krupenevich Rebecca L , Pruziner Alison L , Miller Ross H , Goldman Stephen M , Valerio Michael S , Senchak Lien T , Murphey Mark D , Heltzel David A , Fazio Michael G , Dearth Christopher L , Hager Nelson A 
Published: July 2022

ABSTRACT

Introduction
Knee osteoarthritis (KOA) is a primary source of long-term disability and decreased quality of life (QoL) in service members (SM) with lower limb loss (LL); however, it remains difficult to preemptively identify and mitigate the progression of KOA and KOA-related symptoms. The objective of this study was to explore a comprehensive cross-sectional evaluation, at the baseline of a prospective study, for characterizing KOA in SM with traumatic LL.

Materials and Methods
Thirty-eight male SM with traumatic unilateral LL (23 transtibial and 15 transfemoral), 9.5 ± 5.9 years post-injury, were cross-sectionally evaluated at initial enrollment into a prospective, longitudinal study utilizing a comprehensive evaluation to characterize knee joint health, functionality, and QoL in SM with LL. Presences of medial, lateral, and/or patellofemoral articular degeneration within the contralateral knee were identified via magnetic resonance imaging(for medically eligible SM; Kellgren–Lawrence Grade [n = 32]; and Outerbridge classification [OC; n = 22]). Tri-planar trunk and pelvic motions, knee kinetics, along with temporospatial parameters, were quantified via full-body gait evaluation and inverse dynamics. Concentrations of 26 protein biomarkers of osteochondral tissue degradation and inflammatory activity were identified via serum immunoassays. Physical function, knee symptoms, and QoL were collected via several patient reported outcome measures.

Results
KOA was identified in 12 of 32 (37.5%; KL ≥ 1) SM with LL; however, 16 of 22 SM presented with patellofemoral degeneration (72.7%; OC ≥ 1). Service members with versus without KOA had a 26% reduction in the narrowest medial tibiofemoral joint space. Biomechanically, SM with versus without KOA walked with a 24% wider stride width and with a negative correlation between peak knee adduction moments and minimal medial tibiofemoral joint space. Physiologically, SM with versus without KOA exhibited elevated concentrations of pro-inflammatory biomarker interleukin-7 (+180%), collagen breakdown markers collagen II cleavage (+44%), and lower concentrations of hyaluronic acid (−73%) and bone resorption biomarker N-telopeptide of Type 1 Collagen (−49%). Lastly, there was a negative correlation between patient-reported contralateral knee pain severity and patient-reported functionality and QoL.

Conclusions
While 37.5% of SM with LL had KOA at the tibiofemoral joint (KL ≥ 1), 72.7% of SM had the presence of patellofemoral degeneration (OC ≥ 1). These findings demonstrate that the patellofemoral joint may be more susceptible to degeneration than the medial tibiofemoral compartment following traumatic LL.
A 2-hr binary period for the black hole transient MAXI J0637-430
Authors: Soria Roberto , Ma Ruican , Tao Lian , Zhang Shuang-Nan 
Published: July 2022

ABSTRACT
We revisit various sets of published results from X-ray and optical studies of the Galactic black hole (BH) candidate MAXI J0637-430, which went into outburst in 2019. Combining the previously reported values of peak outburst luminosity, best-fitting radii of inner and outer accretion disc, viewing angle, exponential decay time-scale, and peak-to-peak separation of the He II λ4686 disc emission line, we improve the constraints on the system parameters. We estimate a heliocentric distance d ≈ (8.7 ± 2.3) kpc, a projected Galactocentric distance R ≈ (13.2 ± 1.8) kpc and a height |z| ≈ (3.1 ± 0.8) kpc from the Galactic plane. It is the currently known Milky Way BH candidate located farthest from the Galactic Centre. We infer a BH mass M1 ≈ (5.1 ± 1.6)M⊙, a spin parameter a* ≲ 0.25, a donor star mass M2 ≈ (0.25 ± 0.07)M⊙, a peak Eddington ratio λ ≈ 0.17 ± 0.11 and a binary period $P_{\rm orb} \approx 2.2^{+0.8}_{-0.6}$ hr. This is the shortest period measured or estimated so far for any Galactic BH X-ray binary. If the donor star is a main-sequence dwarf, such a period corresponds to the evolutionary stage where orbital shrinking is driven by gravitational radiation and the star has regained contact with its Roche lobe (low end of the period gap). The three Galactic BHs with the shortest period (≲3 hr) are also those with the highest vertical distance from the Galactic plane (≳2 kpc). This is probably because binaries with higher binding energies can survive faster natal kicks.
Astro-photometric study of M37 with Gaia and wide-field ugi–imaging
Authors: Griggio M , Bedin L R , Raddi R , Reindl N , Tomasella L , Scalco M , Salaris M , Cassisi S , Ochner P , Ciroi S , Rosati P , Nardiello D , Anderson J , Libralato M , Bellini A , Vallenari A , Spina L , Pedani M 
Published: July 2022

Abstract
We present an astrometric and photometric wide-field study of the Galactic open star cluster M37 (NGC 2099). The studied field was observed with ground-based images covering a region of about four square degrees in the Sloan-like filters ugi. We exploited the Gaia catalogue to calibrate the geometric distortion of the large field mosaics, developing software routines that can be also applied to other wide-field instruments. The data are used to identify the hottest white dwarf (WD) member candidates of M37. Thanks to the Gaia EDR3 exquisite astrometry we identified seven such WD candidates, one of which, besides being a high-probability astrometric member, is the putative central star of a planetary nebula. To our knowledge, this is a unique object in an open cluster, and we have obtained follow-up low-resolution spectra that are used for a qualitative characterisation of this young WD. Finally, we publicly release a three-colour atlas and a catalogue of the sources in the field of view, which represents a complement of existing material.
Consistency study of high- and low-accreting Mg ii quasars: no significant effect of the Fe ii to Mg ii flux ratio on the radius–luminosity relation dispersion
Authors: Khadka Narayan , Zajaček Michal , Panda Swayamtrupta , Martínez-Aldama Mary Loli , Ratra Bharat 
Published: July 2022

ABSTRACT
We use observations of 66 reverberation-measured Mg ii quasars (QSOs) in the redshift range 0.36 ≤ z ≤ 1.686 – a subset of the 78 QSOs we previously studied that also have ${\cal R}_{\rm {Fe\, {\small II}}}$ (flux ratio parameter of UV Fe ii to Mg ii that is used as an accretion-rate proxy) measurements – to simultaneously constrain cosmological model parameters and QSO two-parameter and three-parameter radius–luminosity (R–L) relation parameters in six different cosmological models. We find that these QSO R–L relation parameters are independent of the assumed cosmological model and so these QSOs are standardizable through the R–L relations. Also: (1) With the two-parameter R–L relation, we find that the low-${\cal R}_{\rm {Fe\, {\small II}}}$ and high-${\cal R}_{\rm {Fe\, {\small II}}}$ data subsets obey the same R–L relation within the error bars. (2) Extending the two-parameter R–L relation to a three-parameter one does not result in the hoped-for reduction in the intrinsic dispersion of the R–L relation. (3) Neither of the three-parameter R–L relations provide a significantly better fit to the measurements than does the two-parameter R–L relation. These are promising results for the ongoing development of Mg ii cosmological probes. The first and third of these results differ significantly from those we found elsewhere from analyses of reverberation-measured H β QSOs.
Hyper-swivel head domain motions are required for complete mRNA-tRNA translocation and ribosome resetting
Authors: Nishima Wataru , Girodat Dylan , Holm Mikael , Rundlet Emily J , Alejo Jose L , Fischer Kara , Blanchard Scott C , Sanbonmatsu Karissa Y 
Published: July 2022

Abstract
Translocation of messenger RNA (mRNA) and transfer RNA (tRNA) substrates through the ribosome during protein synthesis, an exemplar of directional molecular movement in biology, entails a complex interplay of conformational, compositional, and chemical changes. The molecular determinants of early translocation steps have been investigated rigorously. However, the elements enabling the ribosome to complete translocation and reset for subsequent protein synthesis reactions remain poorly understood. Here, we have combined molecular simulations with single-molecule fluorescence resonance energy transfer imaging to gain insights into the rate-limiting events of the translocation mechanism. We find that diffusive motions of the ribosomal small subunit head domain to hyper-swivelled positions, governed by universally conserved rRNA, can maneuver the mRNA and tRNAs to their fully translocated positions. Subsequent engagement of peptidyl-tRNA and disengagement of deacyl-tRNA from mRNA, within their respective small subunit binding sites, facilitate the ribosome resetting mechanism after translocation has occurred to enable protein synthesis to resume.