bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kemiskinan Anak di Kalimantan Barat Tahun 2021
Authors: Anisa Khusnul Khoiriyah 
Published: September 2022

Mengakhiri kemiskinan menjadi tujuan pertama pada Sustainable Development Goals (SDGs) 2030. Kemiskinan di Provinsi Kalimantan Barat menempati urutan kedua dengan persentase penduduk miskin tertinggi se Pulau Kalimantan pada tahun 2021. Dari data BPS dapat diketahui bahwa persentase anak miskin di Indonesia lebih tinggi dibandingkan dengan persentase penduduk dewasa miskin selama tahun 2015-2021. Menurut data BPS, Provinsi Kalimantan Barat memiliki persentase anak miskin tertinggi di pulau Kalimantan pada tahun 2016. Pada penelitian ini digunakan regresi multilevel logistik biner untuk menganalisis kemiskinan anak hal ini dikarenakan adanya dugaan pengaruh wilayah (kabupaten) terhadap kemiskinan anak. Selain itu, masih sedikit penelitian mengenai kemiskinan anak yang dianalisis secara hierarki dengan menggunakan variabel kontekstual di Provinsi Kalimantan Barat. Dari penelitian ini diperoleh hasil bahwa variabel individual yang berpengaruh signifikan terhadap kemiskinan anak antara lain jumlah anggota rumah tangga (ART), pendidikan kepala rumah tangga (KRT), pendidikan ibu dan status bekerja ibu sedangkan jenis kelamin anak dan status bekerta KRT tidak berpengaruh terhadap kemiskinan anak. Variabel kabupaten yang berpengaruh terhadap kemiskinan anak adalah indeks pembangunan manusia (IPM).
Hubungan Pendidikan dan Perilaku Merokok Remaja Usia 10-17 Tahun di Indonesia
Authors: Hasibuan Johannes 
Published: September 2022

Pendidikan dijadikan sebagai salah satu tolak ukur dalam bersikap dan mengambil keputusan bagi individu dari segi sosial, ekonomi dan juga perilaku hidup sehat yang bebas dari rokok. Penelitian ini menganalisis hubungan perilaku merokok dengan tingkat rata- rata lama sekolah provinsi di Indonesia dan berbagai faktor lain yang mungkin memengaruhi remaja dalam mengkonsumsi rokok di Indonesia. Hasil penelitian membuktikan bahwa adanya hubungan kuat rata-rata lama sekolah dalam mengurangi konsumsi rokok remaja, dimana peningkatan satu tahun lama sekolah dapat mengurangi sebanyak 54 remaja yang merokok. Kesimpulan, pendekatan pendidikan berkontribusi dalam mengurangi perilaku merokok remaja, penelitian lebih lanjut diperlukan dalam memperjelas bagaimana pendidikan mengurangi perilaku merokok.
Body Mass Index and other Demographic Data in Relation to Daily Ambulatory Blood Pressure Parameters
Authors: ORHANOĞLU Timur , DOĞAN Zeki 
Published: September 2022

Objective: In patients with and without a diagnosis of hypertension, we sought to ascertain if body mass index (BMI) and other demographic information affected dipper/non dipper and pulse pressure/pulse pressure index.
Method: Ambulatory blood pressure monitoring (ABPM) analysis of 56 patients with hypertension and 91 patients without hypertension was evaluated. We defined dipper as a drop in mean nocturnal blood pressure (BP) of >10% as compared with mean daytime values (non-dipper percentage 0.05). Diastolic dipper was observed in 46.4% of male patients and 39.3% of female patients in the hypertension group, and there was no statistically significant difference between them (p>0.05). In examination cases (group 2), Although the incidence of systolic dipper and diastolic dipper in male subjects (46.5% and 60.5%, respectively) was higher than in female subjects (27.1% and 39.6%, respectively), this difference was close to significance, but not statistically significant (p>0.05). There was no statistically significant difference between the mean age and BMI of systolic dipper and non-dipper cases (p>0.05). Besides, the mean age of the diastolic non dipper cases was statistically significantly higher than the diastolic dipper cases (p:0.048), and the mean BMI of the diastolic non dipper cases was statistically significantly higher than the diastolic dipper cases (p:0.034).
Conclusion: It may be beneficial to include the mean pulse pressure/pulse pressure index in the evaluation of general, awake, and asleep pulse pressure while evaluating the ABPM result.
Structure of Ti-Ta Alloys Fabricated by Electron-beam Surface Alloying
Authors: Ormanova Maria , Kotlarski Georgi , Bezdushnyi Ruslan , Ivanov Nikolay , Dechev Dimitar , Valkov Stefan 
Published: September 2022

In the present study, Ta coatings with a thickness of 1.7 and 4.2 μm were deposited on Ti samples through reactive magnetron sputtering. The coatings are furthermore treated by a scanning electron beam in order to form the Ti-Ta surface alloy. A change in the phase composition of the Ti-Ta alloy was observed through X-ray diffraction (XRD). The microstructure and the chemical composition of the samples were studied via scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). The results indicate that in both cases the thickness of the alloyed zone remains the same at about 50 μm. The concentration of Ta in the alloyed zone increases with the increase in thickness of the pre-applied coating. The sample with the 1.7 μm Ta coating has a single-phase hexagonal closed packed structure, corresponding to the \(\alpha \) phase, whilst the sample with the 4.2 μm coating exhibits a biphasic hexagonal closed-packed structure and a body-centred cubic structure, corresponding to \(\alpha '\) martensitic and β phases.
Can the Physical Parameters with the Support Vector Machine (SVM) Method Able to Classify Benign and Malignant Breast Cancer?
Authors: Gunawan Anak Agung Ngurah , Wibawa I. Made Satriya , Mahendra Anak Agung Ngurah Surya , Negara Anak Agung Ngurah Franky Kusuma , Negara Anak Agung Ngurah Frady Cakra 
Published: September 2022

Objective: Evaluating the diagnostic performance of SVM to classify benign and malignant by performing a meta-analysis.
Methods: The data used for this study were secondary data. It consisted of 221 mammogram images (mean age 57.5 years) with 164 malignant and 57 benign, taken from a radiological database that has been examined by a radiologist with more than 20 years of experience. Also, histopathological record data that had been examined by an oncologist with more than 20 years of experience. Mammograms were taken from January 2022 to June 2022. In all, 221 mammograms consisting of 164 malignant and 57 benign were used as SVM method training, and 20 mammograms consisting of 10 malignant and 10 benign were used to test the performance of the SVM method. It was then evaluated using pathology results as the gold standard.
Results: Benign had a significantly lower deviation (an average of 29.2661230 ± 10.14916673) than malignant (an average of 33.1841234 ± 11.70238757). The SVM method performance value obtained the values ​​of TP, FP, TN, FN, accuracy, sensitivity, Specificity, and Precision, respectively 7,7, 3, 3, 50%, 70%, 30%, and 50%.
Conclusion: A proper performance to distinguish benign and malignant can be obtained using the physical deviation parameters with the SVM classification approach. However, these findings should be proven in larger datasets with different mammographic scanners. Our meta-analysis shows that the physical parameters and SVM have high sensitivity but low specificity. Of the nine physical parameters in the mammogram, only the parameter deviation was significant to distinguish between benign and malignant. The SVM method proved to be able to differentiate between benign and malignant.
Hepatocellular Injury Ameliorated by a Common African Food, Parkia biglobosa
Authors: Onyekachi O. I. N. , Orji S. F. , Ugwu C. N. , Igwenyi C. , Uche C. L. , Abali I. O. , Nwobodo M. U. , Iwuoha C. E. , Chika-Igwenyi N. M. , Onyeaghala C. A. , Agu F. U. , Airaodion A. I. 
Published: September 2022

Background: Parkia biglobosa seed has been reported to possess hepatoperotective potential. Therefore, this study sought to investigate its ability in ameliorating KBrO3-induced hepatotoxicity.
Methodology: P. biglobosa was extracted with soxhlet extractor with 95% ethanol as the solvent. Twenty-four adult male Wistar rats were acclimatized under laboratory conditions and were randomly grouped into A, B, C and D. Group A was given distilled water orally. Animals in groups B, C and D were administered 100 mg/kg body weight of potassium bromate, but groups C and D were also treated with 100 and 200 mg/kg body weight of P. biglobosa respectively. Both potassium bromate and P. biglobosa were freshly prepared on daily basis and administered to rats by oral gavage. After 28 days of treatment, the animals were sacrificed under mild diethyl ether anaesthetization 24 hours after cessation of last treatment. Blood and liver tissue were collected.
Results: The findings demonstrated that, when compared to the control group, KBrO3 caused a significant increase (P˂0.05) in ALT, AST, LDH, ALP, total bilirubin (TB), conjugated bilirubin (CB), and unconjugated bilirubin (UB) levels, but decreased total protein, albumin and globulin in the serum of animals. In the liver cells, KBrO3 reduced hepatic biomarkers. These perturbations were neutralized in the groups treated with 100 and 200 mg/kg body weight, respectively.
Conclusion: The result of the present study revealed that KBrO3 is hepatotoxic at a dose of 100 mg/kg body weight. The result further suggests that P. biglobosa possesses hepatoprotective properties in rats in vivo. This study can be replicated in human trial.
Field Control of Maize Borers Using Aqueous Seed Extracts of Thevetia Peruviana (Pers.) K. Schum
Authors: Mboussi Serge Bertrand , Nsangou Abdou Nourou Kone , Heu Alain , Belibi Marlyse Zita Mboudou , Zemko Patrice Ngatsi , Dooh Jules Patrice Ngoh , Ambang Zachée 
Published: September 2022

Aims: In order to find an alternative to chemical control, the insecticidal potential of aqueous extracts of Thevetia peruviana seeds formulated at 16.66 g/l were tested in the field on the maize stalk borer species.
Study Design: The factorial design in subdivided plots or "split-plot" with four replicates and two factors studies was used on an area of 250 m2.
Place and Duration of Study: The experiment was carried out in a field located in the city of Yaounde, Cameroon where cassava was grown beforehand, between July and October 2021.
Methodology: The extracts at 250 g per 15 l of water were tested against a synthetic insecticide Cypercal at 37.5 ml per 5 l of water and an absolute control (untreated) in a four replicate split-plot device. Two maize varieties (V1: CMS 8704; V2: local) and three treatments (T1: control; T2: T. peruviana seed extract; T3: Cypercal 12 EC) were used. The aqueous extract of T. peruviana was applied by spraying on stems, leaves and leaf cones from 5th to 9th weeks after sowing (SAS). Data were recorded on growth parameters, stem borer density, and maize grain yield.
Results: The results show that the application of the treatments resulted in a good development of the growth parameters in the two maize varieties used. Two species of borer Busseola fusca and Sesamia calamistis belonging to the order Lepidoptera were identified. The density of maize stalk borers was significantly reduced (T2: 3 borers) in the subplots treated with aqueous extracts compared to the control (T1: 10 borers). Treatment T2 (2.05 t/ha) gave higher grain yield than the control (1.41 t/ha).
Conclusion: The aqueous extracts of T. peruviana seeds having thus shown a strong insect repellent potential in the field can therefore be integrated into the framework of biological control that protects the environment and human health.
Exit Rates of Accountable Care Organizations That Serve High Proportions of Beneficiaries of Racial and Ethnic Minority Groups
Authors: Lin Sunny C. , Maddox Karen E. Joynt , Ryan Andrew M. , Moloci Nicholas , Shay Addison , Hollingsworth John Malcolm 
Published: September 2022

ImportanceThe Medicare Shared Savings Program provides financial incentives for accountable care organizations (ACOs) to reduce costs of care. The structure of the shared savings program may not adequately adjust for challenges associated with caring for patients with high medical complexity and social needs, a population disproportionately made up of racial and ethnic minority groups. If so, ACOs serving racial and ethnic minority groups may be more likely to exit the program, raising concerns about the equitable distribution of potential benefits from health care delivery reform efforts.ObjectiveTo evaluate whether ACOs with a high proportion of beneficaries of racial and ethnic minority groups are more likely to exit the Medicare Shared Savings Program and identify characteristics associated with this disparity.Design, Setting, and ParticipantsThis retrospective observational cohort study used secondary data on Medicare Shared Savings Program ACOs from January 2012 through December 2018. Bivariate and multivariate cross-sectional regression analyses were used to understand whether ACO racial and ethnic composition was associated with program exit, and how ACOs with a high proportion of beneficaries of racial and ethnic minority groups differed in characteristics associated with program exit.ExposuresRacial and ethnic composition of an ACO’s beneficiaries.Main Outcomes and MeasuresShared savings program exit before 2018.ResultsThe study included 589 Medicare Shared Savings Program ACOs. The ACOs in the highest quartile of proportion of beneficaries of racial and ethnic minority groups were designated high-proportion ACOs (145 [25%]), and those in the lowest 3 quartiles were designated low-proportion ACOs (444 [75%]). In unadjusted analysis, a 10–percentage point increase in the proportion of beneficiaries of racial and ethnic minority groups was associated with a 1.12-fold increase in the odds of an ACO exit (95% CI, 1.00-1.25; P = .04). In adjusted analysis, there were significant associations among high-proportion ACOs between characteristics such as patient comorbidities, disability, and clinician composition and a higher likelihood of exit.Conclusions and RelevanceThe study results suggest that ACOs that served a higher proportion of beneficaries of racial and ethnic minority groups were more likely to exit the Medicare Shared Savings Program, partially because of serving patients with greater disease severity and complexity. These findings raise concerns about how current payment reform efforts may differentially affect racial and ethnic minority groups.
Comparative Outcomes and Safety of Vedolizumab vs Tumor Necrosis Factor Antagonists for Older Adults With Inflammatory Bowel Diseases
Authors: Singh Siddharth , Iversen Aske T. , Allin Kristine H. , Jess Tine 
Published: September 2022

ImportanceObservational comparative effectiveness studies can inform the positioning of biologic therapies for older patients with inflammatory bowel disease (IBD) who are underrepresented in clinical trials.ObjectiveTo compare the effectiveness and safety of vedolizumab vs tumor necrosis factor (TNF) for older patients with IBD.Design, Setting, and ParticipantsThis active comparator, new-user design, comparative effectiveness study was conducted between January 1, 2005, and December 31, 2018, among 754 older patients (aged ≥50 years) with IBD from the Danish National Patient Register. The mean follow-up after treatment initiation took place at 32 to 40 weeks. Statistical analysis was performed from February 1 to April 27, 2022.InterventionsTreatment with vedolizumab or TNF antagonists.Main Outcomes and MeasuresThe primary effectiveness outcome was treatment failure, defined as the composite risk of IBD-related hospitalization, IBD-related surgery, or a new corticosteroid prescription more than 6 weeks after initiation of treatment with biologic therapy. Secondary effectiveness outcomes were time to each individual component of the composite effectiveness outcome. The primary safety outcome was the risk of serious infections, defined as infections requiring hospitalization. A 1:1 propensity score–matched analysis was conducted, accounting for patient-, disease-, and treatment-associated factors.ResultsThe study compared 377 older patients with IBD with incident use of vedolizumab (202 women [53.6%]; mean [SD] age, 61.2 [8.3] years; 177 [46.9%] with Crohn disease) vs 377 patients with incident use of TNF antagonists (206 women [54.6%]; mean [SD] age, 61.3 [8.1] years; 182 [48.3%] with Crohn disease). Overall, vedolizumab was associated with an increased risk of treatment failure compared with TNF antagonists (1-year risk, 45.4% vs 34.7%; adjusted hazard ratio [HR], 1.31; 95% CI, 1.02-1.69), including higher risk of IBD-related hospitalization (1-year risk, 27.8% vs 16.3%; adjusted HR, 1.48; 95% CI, 1.03-2.15) and IBD-related major abdominal surgery (1-year risk, 21.3% vs 8.0%; adjusted HR, 2.39; 95% CI, 1.45-3.94). In subgroup analysis by IBD phenotype, among patients with Crohn disease, vedolizumab was associated with a 77% higher risk of treatment failure (adjusted HR, 1.77; 95% CI, 1.21-2.58), while no difference in risk of treatment failure was seen among patients with ulcerative colitis (adjusted HR, 1.04; 95% CI, 0.75-1.43; P = .03 for interaction). There was no significant difference in the risk of serious infections, overall (1-year risk, 8.2% vs 8.7%; adjusted HR, 1.04; 95% CI, 0.58-1.85) and by IBD phenotype.Conclusions and RelevanceIn this comparative effectiveness study of older patients with IBD, vedolizumab was associated with a higher risk of treatment failure compared with TNF antagonists, particularly among patients with Crohn disease, without offering a significant safety advantage.
Zwitterionic Polymer/Polydopamine Coating of Electrode Arrays Reduces Fibrosis and Residual Hearing Loss after Cochlear Implantation
Authors: Chen Anning , Chen Dongxiu , Lv Kai , Li Guowei , Pan Jing , Ma Dong , Tang Jie , Zhang Hongzheng 
Published: September 2022

AbstractSince the first surgery 50 years ago, cochlear implantation (CI) is the major treatment for patients with severe sensorineural hearing loss. However, unexpected foreign body reactions (FBRs) after surgery are reported in 90% of CI recipients, resulting in the formation of fibrosis in the cochlea and progressive residual hearing loss. Zwitterion modification is universally used to reduce bio‐fouling and suppress FBRs but never for CI. In the present study, a zwitterionic coating is developed, which is composed of poly sulfobetaine methacrylate (PSB) and polydopamine (PDA) for cochlear implants. The PSB‐PDA coating shows a series of characters for an ideal anti‐FBRs material, including super‐hydrophilicity, low protein and cell adsorption, long‐term stability, and high biocompatibility. Compared to the uncoated controls, PSB‐PDA coating inhibits the activation of macrophages and reduces the release of inflammatory factors (TNF‐α, IL‐1β, NO) and fibrosis‐related factors (TGF‐β1, α‐SMA, collagen I). PSB‐PDA coated electrode arrays suppress fibrosis completely and preserve residual hearing significantly in rat CI models. These results suggest that PSB‐PDA coating is a novel strategy for anti‐fibrosis to improve the outcomes of CI.
Squid Suckerin‐Spider Silk Fusion Protein Hydrogel for Delivery of Mesenchymal Stem Cell Secretome to Chronic Wounds
Authors: Koh Kenrick , Wang Jun Kit , Chen James Xiao Yuan , Hiew Shu Hui , Cheng Hong Sheng , Gabryelczyk Bartosz , Vos Marcus Ivan Gerard , Yip Yun Sheng , Chen Liyan , Sobota Radoslaw M. , Chua Damian Kang Keat , Tan Nguan Soon , Tay Chor Yong , Miserez Ali 
Published: September 2022

AbstractChronic wounds are non‐healing wounds characterized by a prolonged inflammation phase. Excessive inflammation leads to elevated protease levels and consequently to a decrease in growth factors at wound sites. Stem cell secretome therapy has been identified as a treatment strategy to modulate the microenvironment of chronic wounds via supplementation with anti‐inflammatory/growth factors. However, there is a need to develop better secretome delivery systems that are able to encapsulate the secretome without denaturation, in a sustained manner, and that are fully biocompatible. To address this gap, a recombinant squid suckerin‐spider silk fusion protein is developed with cell‐adhesion motifs capable of thermal gelation at physiological temperatures to form hydrogels for encapsulation and subsequent release of the stem cell secretome. Freeze–thaw treatment of the protein hydrogel results in a modified porous cryogel that maintains slow degradation and sustained secretome release. Chronic wounds of diabetic mice treated with the secretome‐laden cryogel display increased wound closure, presence of endothelial cells, granulation wound tissue thickness, and reduced inflammation with no fibrotic scar formation. Overall, these in vivo indicators of wound healing demonstrate that the fusion protein hydrogel displays remarkable potential as a delivery system for secretome‐assisted chronic wound healing.
Visualized Gallium/Lyticase‐Integrated Antifungal Strategy for Fungal Keratitis Treatment
Authors: He Jian , Ye Yang , Zhang Dongxiao , Yao Ke , Zhou Min 
Published: September 2022

AbstractFungal keratitis has been one of the common corneal infections that causes blindness, but an effective antifungal strategy remains a challenge. The exopolysaccharides both in the fungal cell walls and biofilms are a key that acts as a permeation barrier to weaken the therapeutic effect of antifungal agents. Herein, lyticase and gallium ions co‐integrated nanosystems (MLPGa) are presented that can degrade exopolysaccharides and then effectively eradicate both planktonic Candida albicans and mature biofilms. The potential antifungal mechanism involves reactive oxygen species (ROS) production and metabolic interference of antioxidant‐related genes, exopolysaccharide‐related genes, iron‐ion‐utilization‐related genes, fungal/biofilm‐development‐related genes, and virulence genes. Meanwhile, the Raman signals generated by the chelation between the nanosystems and the gallium ions provide a real‐time visualization tool to monitor Ga release. Finally, the MLPGa‐based antifungal strategy with good biocompatibility achieves a satisfactory therapeutic effect in a fungal keratitis mouse model. This study provides a unique approach to the effective treatment of fungal keratitis in clinical practice.
Benzannulation and N‐Annulation of β‐Ketoenamines for Synthesizing Aniline and Pyridine Derivatives Using DMSO as a Methine Source
Authors: Ganjan Dalai Pallaba , Panda Niranjan 
Published: September 2022

AbstractBenzannulation and N‐annulation of β‐ketoenamines by the in‐situ generated methyl(methylene)sulfonium ion from the reaction of dimethyl sulfoxide (DMSO) and 1,2‐dibromoethane (DBE) was achieved. The β‐ketoenamines underwent N‐annulation to pyridine derivatives, while the N‐alkylated enamines were benzannulated to afford substituted anilines. The utility of the intermediate methyl(methylene)sulfonium ion was further extended for synthesizing methylene‐bridged bis‐1,3‐dicarbonyl compounds.magnified image
Understanding the importance of farmer–NGO collaboration for sustainability and business strategy: Evidence from the coffee supply chain
Authors: Fontana Enrico , Pisalyaput Nick 
Published: September 2022

AbstractDespite the attention to governance strategies based on international market intervention and product differentiation, research on how farmers and NGOs collaborate and share knowledge in production countries to help address sustainability challenges bottom‐up remains limited. Through evidence from the coffee supply chain, this article endorses a human ecology viewpoint and shows how farmer–NGO collaboration in domestic markets can help foster relevant environmental, social, and economic upgrades. More significantly, it provides evidence of the importance of farmer–NGO collaboration for business strategy and indicates how NGOs can help farmers to grow as independent business owners and build their own market channels locally. By conceptualizing a strategic framework of farmer–NGO collaboration to better overcome sustainability challenges bottom‐up and empower farmers as independent business owners, while also outlining the possible unintended consequences of such collaboration, this article finally contributes to the literature on the coffee supply chain and offers generalizable takeaways for NGO strategy.