bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geographical Differences in Kidney Cancer Outcomes of Patients Treated with Immunotherapy: A Systematic Review
Authors: Gonçalves Vinicius Knackfuss , Monteiro Fernando Sabino Marques , Gazola Antonia Angeli , Pizzolo Felipe , Hübner Júlia Elisa , Pellegrini Rodrigo , Borba Alessandra , Fay André P. 
Published: June 2022

BACKGROUND: Immune checkpoint inhibitors (ICI) have shown clinical benefit among patients with advanced kidney cancer. Their cost burden hardens its access, especially in low- and middle-income countries. To set solutions, the impact of geographical and socioeconomic differences in the clinical outcomes and survival of renal cell carcinoma (RCC) patients needs to be explored. OBJECTIVE: This review aimed to understand if geographical differences affected the clinical outcomes of RCC patients receiving immunotherapy. METHODS: This study reviewed 45 studies that examined the OS and PFS of RCC patients undergoing ICI (2010–2020) selected from a 3028-study database search conducted on PubMed and grey literature. The selected studies were divided into groups: Asia, multicentric studies, Europe and Anglo-America. The lethality and income of the geographical locations were measured and discussed. RESULTS: Weighted average (WAVG) of mPFS and mOS were 8,47 months, and 40,6 months in Asia. The WAVG of mOS were 12.2 months, and 20.22 months in the Anglo-American population (15 studies; 943 patients). In multicentric studies (4 studies; 1834 patients) the WAVG mPFS was 10,06. European group (13 studies; 3143 patients) had 6.1 and 20.24 months mPFS and mOS, respectively. The exploratory analysis on income and RCC lethality has shown an absolute decline of 8.7% (CI 10.1 to 7.3% - p < 0.05) in RCC lethality, when income is raised by 100%. CONCLUSION: Clinical benefit from ICI varies across the globe. A wide access to ICI, and evaluation of biological aspects of the disease will allow a better understanding of the impact of geographic regions in the clinical outcome of patients receiving ICI and the etiology of potential differences.
Manual de los Reglamentos del Agua en Florida: Manejo y Almacenamiento de las Aguas Superficiales
Authors: Olexa Michael T. , Broome Zachary 
Published: June 2022

Este manual está diseñado para proporcionar un resumen exacto, actual y autorizado, de las principales leyes Federales y de Florida que están directa o indirectamente relacionadas con la agricultura.
This revised document is part of a series of 37 brief fact sheets, the Spanish-language version of the Handbook of Florida Water Regulation. Published by the UF Department of Food and Resource Economics, May 2012.
FE088/FE088: Manual de los Reglamentos del Agua en Florida: Manejo y Almacenamiento de las Aguas Superficiales (ufl.edu)
Manual de los Reglamentos del Agua en Florida: Ley de los Everglades para Siempre de Florida
Authors: Olexa Michael T. , Broome Zachary 
Published: June 2022

Este manual está diseñado para proporcionar un resumen exacto, actual y autorizado, de las principales leyes Federales y de Florida que están directa o indirectamente relacionadas con la agricultura.
This revised document is part of a series of 37 brief fact sheets, the Spanish-language version of the Handbook of Florida Water Regulation. Published by the UF Department of Food and Resource Economics, May 2012.
FE092/FE092: Manual de los Reglamentos del Agua en Florida: Ley de los Everglades para Siempre de Florida (ufl.edu)
Manual de los Reglamentos del Agua en Florida: Sistemas de Tanques de Almacenamiento de Contaminantes
Authors: Olexa Michael T. , Broome Zachary 
Published: June 2022

Este manual está diseñado para proporcionar un resumen exacto, actual y autorizado, de las principales leyes Federales y de Florida que están directa o indirectamente relacionadas con la agricultura.
This revised document is part of a series of 37 brief fact sheets, the Spanish-language version of the Handbook of Florida Water Regulation. Published by the UF Department of Food and Resource Economics, May 2012.
FE096/FE096: Manual de los Reglamentos del Agua en Florida: Sistemas de Tanques de Almacenamiento de Contaminantes (ufl.edu)
Ideas and Experiences of Peace in Italian Confraternities of the Late Middle Ages: Specifics and Developments
Authors: Rossi Maria Clara 
Published: June 2022

Starting from the assumption — underlined by most of the scholarship — that lay devotional association in the Late Middle Ages is largely characterized by its “vocation for peace” and its efforts to attenuate and overcome the conflicts inherent to contemporary urban society, this article seeks to identify in a less generic and more concrete manner the contributions confraternities made to social peace. The first part of the article examines the different meaning that the concept of peace might have had for the men and women who gathered in confraternities; the second part, instead, provides some examples from various Italian cities — Bologna, Assisi, Padua, Bergamo, Venice, and Florence.
PEMBERDAYAAN MASYARAKAT LOKAL DALAM AKTIVITAS PARIWISATA BUDAYA BALI
Authors: Murtana I Nyoman 
Published: June 2022

In social life, art considerably can help to perfect human and their society in physi- cal, spiritual and psychological side. Â Based on their belief the role and function of art, like mentioned above, resulting many kinds of art which goes to manifestation of artist creativity and their society. Â No exception happens in Bali, too. Â There are lots of various arts which are as the hairs of an old agricultural-feudalism society that people today of Â desperately reborn and developed them.Â Â In case of one of preservation conceptions, it Â is made such as classification of art; sacred art and profane. Â The classification is significantly made to anticipation tourism organizer to not harmfully perform that sacred art to be sold by tourist. Â Unfortunately, this classification has no cultural power to be obeyed, so till today it is consequently still be a conflict. Â What is all about happens due to that tourism such as has a big power to screw up that classifications of sacred art and profane. Â It will be more ridiculous when there is an art work which previously become a sacred art must be sold for the sake tourists satisfaction. Â It seems that tourism activities is identical to market. Bali, actually, is merely the market. Â In â€œsmallâ€ part it goes to art market such as art performance, handy craft, painting, sculpture, and other else, then natural tourism object on the other side.Â Â Based on the facts show that art reproduction only be done by a small society which has skill to create work of arts. Â Meanwhile, the small society has no evenly big chance due to the local government indicated less atten- tion to empowering them. Â Today, there are some people who has desperately kept the Â maintaining the image of Balinese cultural identity by undergoing traditional and religion Â ritual ceremony hugely and attractively, but it comes to unpleasantly that the lesson just to be anjoyed by as a merely profane performance.Â Key words: local society, tourism, empowering.
KARYA FOTOGRAFI INFRARED DIBYO GAHARI
Authors: Yulianto Arif 
Published: June 2022

Artikel ini adalah hasil dari penelitian tentang â€œKarya FotografiÂ InfraredÂ Dibyo Gahariâ€ bertujuan untuk mengkaji mengapa Dibyo Gahari memilih fotografi Infrared, bagaimana proses â€œpengoprekanâ€Â infraredÂ Dibyo Gahari dan bagaimana karya infrared Dibyo Gahari apabila dikaji dengan pendekatan estetika. Penelitian ini adalah penelitian kualitatif menggunakan metode deskriptif dengan pendekatan estetika. Metode pengumpulan data dengan studi pustaka, observasi, dan wawancara. Untuk menjelaskan kajian estetika digunakan teori estetika Monroe Breadsley. Hasil penelitian menunjukkan, bahwa Dibyo Gahari memilih fotografiÂ infraredÂ karena warnaÂ false colourÂ yang menjadikan karyanya unik dan dramatis. Keunikannya terjadi pada warna-warna yang berubah menjadi warna kecoklatan atau keputihan.Â Untuk foto pada kulit manusia menjadi pucat. Proses pengoprekan karya Dibyo Gahari yang menjadikan karyanya lebih unik dari sebelumnya, yaitu dengan memasang sebuah lensa khususinfraredÂ di depan sensor menggantiÂ hot mirrorÂ dalam kamera DSLRnya. Estetika yang terkandung dalam karya fotografi Dibyo Gahari yang memberikan nuansa keindahan yaitu pada dominansi obyek dan dominansi warna kontras antara obyek yang memberi kesatuan, saling melengkapi antara obyek, yang satu dengan yang lain.Â Kata kunci:Â Infrared, Dibyo Gahari.
SENI LUKIS INDONESIA Problem Refleksivitas Dalam Pemikiran Filsafat Post-ModernismeTerhadap Masyarakat Multikultural
Authors: - Dharsono 
Published: June 2022

Perjalanan seni lukis sejak perintisan R. Saleh sampai awal abad XXI ini, terasa masih terombang-ambing oleh berbagai benturan konsepsi. Kemapanan seni lukis Indonesia yang belum mencapai tataran berhasil itu, sudah diporak-porandakan oleh gagasan modernisme yang membuahkan seni alternatif, dengan munculnya seni konsep (conseptual art): â€œInstalasi Artâ€, dan â€œPerformance Artâ€, yang pernah menjamur di pelosok kampus perguruan tinggi seni sekitar 1993-1996. Kemudian muncul berbagai alternatif semacam â€œkolaborasiâ€ sebagai mode 1996/97. Bersama itu pula seni lukis konvensi dengan berbagai gaya menghiasi galeri-galeri, yang bukan lagi sebagai bentuk apresiasi terhadap masyarakat, tetapi merupakan bisnis alternatif investasi. Seniman dihadapkan dalam dua pilihan: pertama, tetap sebagai seniman idealis yang mencoba mempertahankan nilai, dengan mempertahankan seni sebagai terapi batin, sehingga mampu menjadi monometalitas zaman, seni senafas dengan zamannya, seni sebagai satu potret kehidupan. Kedua,Â masuk dalam blantika seni lukis Indonsia, yang cukup menggiurkan. ApabilaÂ seniman modern mencoba menceritakan dirinya lewatÂ ekspresi pribadinya, dengan mengungkapkan atau mengekspresikanÂ pengalaman estetiknya dalam simbol-simbol ekspresi yang penuh realitas makna. Maka paradigma seni dalam fenomena kiniÂ (kontemporer) menawarkan berbagai gagasan yang ia racik dalamÂ multi media,Â multi-ideaÂ dan bahkan multi tafsir, menghasilkanÂ realitas wacanaÂ Kata kunci:Â pencarian identitas, dekontruksi dan sentuhan tradisi
Aikaa hengittämiseen
Authors: Onnismaa Jussi 
Published: June 2022

Teoksen kirjoittajat ovat kokeneita työnohjaajia. He kokoontuivat usean vuoden ajan hautomoiksi nimeämiinsä tapaamisiin pohtimaan työnohjausta ja sen etiikkaa. Mitä työnohjaaja voi ohjauksessa tehdä? Millaista valtaa hänellä on? Mitkä ovat vastuun rajat? Millainen ohjaus tuottaa ohjattaville hyvää, millainen pahaa? Miten lojaalius eri osapuolille – ohjattaville ja heidän asiakkailleen, tilaajalle ja organisaatiolle – toteutuu? Kirja on tarkoitettu työnohjaajille, työyhteisöjen esihenkilöille ja kehittäjille.
”Kansainvälisyys on asenne jokapäiväisessä elämässä”
Authors: Kaasik-Krogerus Sigrid 
Published: June 2022

Viimeisten vuosikymmenien aikana korkeakoulutuksen kansainvälistyminen on määrittänyt korkeakoulujen kehitystä kaikkialla maailmassa ja siitä on tullut myös merkittävä tutkimusaihe. Aiemman tutkimuksen perusteella korkeakoulutuksen kansainvälistymistä voi pitää monisyisenä ja ristiriitaisena prosessina. Tässä artikkelissa lähestyn kansainvälistymistä opiskelijanäkökulmasta tutkimalla suomalaisten yliopisto-opiskelijoiden näkemyksiä kansainvälistymisestä. Valikoin tutkittaviksi Venäjän ja itäisen Euroopan valtakunnallisten asiantuntijaopintojen (VIExpert) suorittajat, koska aluetutkimusta on pidetty yhtenä esimerkkinä kansainvälistymisestä jo vuosikymmenien ajan. Toteutin tutkimuksen avoimista kysymyksistä koostuvan verkkokyselyn avulla. Aineiston analyysissä käytin lähilukua. Tutkimus osoittaa, miten kansainvälistymisen määrittelyssä tärkeinä tekijöinä näyttäytyvät kielet sekä Suomesta että Suomeen suuntaava akateeminen liikkuvuus. Kieliin ja liikkuvuuteen keskittyvän näkökulman haastaa näkemys, jonka mukaan korkeakoulutuksen kansainvälistyminen koskee kaikkea opetuksen sisältöä sekä yliopistojen akateemista henkilökuntaa ja kaikkia opiskelijoita. Näin opiskelijoiden näkemyksessä korostuu myös kansainvälistymisen jokapäiväisyys, joka samalla häivyttää näkyvistä kansainvälistymisen taustalla vaikuttavat toimijat.

Over the past decades, internationalisation has become one of the key issues in higher education. Respectively, the topic has gained prominence as a subject of academic research. According to various studies, the internationalisation of higher education is a multifaceted and controversial process. In this article, internationalisation is approached from student perspective. The empirical data were gathered among the students of Expertise in Russian and Eastern European Studies (ExpREES). The data were gathered by an e-survey made up of open questions. Close reading was used to analyse the data. According to the results, students frame both languages and academic mobility as core issues of internationalisation and challenge their special role by emphasising that internationalisation concerns all curricula as well as all academic staff and students. Hereby, internationalisation is dealt with as an inherent part of everyday academic life, whilst the various actors behind the policy of internationalisation and their impact on the internationalisation process become blurred.
Rapid Visual Detection of Plasmodium Using Recombinase-Aided Amplification With Lateral Flow Dipstick Assay
Authors: Lin Hong , Zhao Song , Liu Yanhong , Shao Lei , Ye Yuying , Jiang Nizhen , Yang Kun 
Published: June 2022

BackgroundMalaria is a global public health problem. China has had no case of indigenous malaria since 2016. However, imported cases of malaria remain an issue among travelers, overseas workers, and foreign traders. Although these cases are always asymptomatic, if they donate blood, there is a great risk of transfusion transmitted-malaria (TTM). Therefore, blood banks need a rapid screening tool to detect Plasmodium species.MethodsWe designed an assay using recombinase-aided amplification (RAA) and a lateral-flow dipstick (LFD) (RAA-LFD) to detect the 18S ribosomal RNA gene of Plasmodium species. Sensitivity was evaluated using a recombinant plasmid and Plasmodium genomic DNA. Specificity was evaluated using DNA extracted from the blood of patients with malaria or other infectious parasites. For clinical assessment, blood samples from patients with malaria and blood donors were evaluated.ResultsThe RAA-LFD assay was performed in an incubator block at 37°C for 15 min, and the amplicons were visible to the naked eye on the flow dipsticks within 3 min. The sensitivity was 1 copy/μL of recombinant plasmid. For genomic DNA from whole blood of malaria patients infected with P. falciparum, P. vivax, P. ovale, and P. malariae, the sensitivity was 0.1 pg/μL, 10 pg/μL, 10-100 pg/μL, and 100pg/μL, respectively. The sensitivity of this assay was 100pg/μL. No cross-reaction with other transfusion-transmissible parasites was detected.ConclusionsThe results demonstrated that this RAA-LFD assay was suitable for reliable field detection of Plasmodium species in low-resource settings with limited laboratory capabilities.
Preferences in the Intention to Download a COVID Tracing App: A Discrete Choice Experiment Study in the Netherlands and Turkey
Authors: Folkvord Frans , Peschke Lutz , Gümüş Ağca Yasemin , van Houten Karlijn , Stazi Giacomo , Roca-Umbert Ana , Güneş Peschke Seldağ , Seyfafjehi Seyedehshahrzad , Gallego Alba , Gaeta Eugenio , Fico Giuseppe , Karinsalo Anni , Lupianez Villanueva Francisco 
Published: June 2022

IntroductionHigh levels of adoption and usage for the COVID Tracing Apps (CTA) among the population is a stipulated prerequisite for success of the implementation of these apps, aiming to mitigate the pandemic and track spreading of the virus more efficient and effectively. In the current study, the main objective was to investigate individuals' preferences in the intention to download a COVID-19 tracing app in a pilot-study in both the Netherlands and Turkey.MethodsWe conducted a discrete choice experimental study through an online survey in two countries (the Netherlands [N = 62] and Turkey [N = 83]), with four different attributes: (1) data protection (data protection vs. no information), (2) manufacturer (government vs. company), (3) reward (no reward vs. voucher as a reward) and (4) gaming (no gaming elements vs. gaming elements). Participants were recruited among a student population.ResultsThe results showed that data protection is one of the most important factors that significantly increases the probability to adopt a CTA. In general, the manufacturer, reward or gaming affected the probability to download the CTA less.DiscussionsHealth authorities worldwide have generally released high quality CTA, although scientific studies assessing the most important factors that describe and predict the intention to download is limited. Sensitive personal data is collected through these apps, and may potentially threaten privacy, equality and fairness, which are important attributes to take into account when developing or launching a CTA, following the results of this study.
Coronary Flow Evaluation in Heart Transplant Patients Compared to Healthy Controls Documents the Superiority of Coronary Flow Velocity Reserve Companion as Diagnostic and Prognostic Tool
Authors: Cecere Annagrazia , Kerkhof Peter L. M. , Civieri Giovanni , Angelini Annalisa , Gambino Antonio , Fraiese Angela , Bottio Tomaso , Osto Elena , Famoso Giulia , Fedrigo Marny , Giacomin Enrico , Toscano Giuseppe , Montisci Roberta , Iliceto Sabino , Gerosa Gino , Tona Francesco 
Published: June 2022

BackgroundDistinct contributions by functional or structural alterations of coronary microcirculation in heart transplantation (HT) and their prognostic role have not been fully elucidated. We aimed to identify the mechanisms of coronary microvascular dysfunction (CMD) in HT and their prognostic implications.Methods134 patients, surviving at least 5 years after HT, without evidence of angiographic vasculopathy or symptoms/signs of rejection were included. 50 healthy volunteers served as controls. All underwent the assessment of rest and hyperemic coronary diastolic peak flow velocity (DPVr and DPVh) and coronary flow velocity reserve (CFVR) and its inherent companion that is based on the adjusted quadratic mean: CCFVR = √{(DPVr)2 + (DPVh)2}. Additionally, basal and hyperemic coronary microvascular resistance (BMR and HMR) were estimated.ResultsBased on CFVR and DPVh, HT patients can be assigned to four endotypes: endotype 1, discordant with preserved CFVR (3.1 ± 0.4); endotype 2, concordant with preserved CFVR (3.4 ± 0.5); endotype 3, concordant with impaired CFVR (1.8 ± 0.3) and endotype 4, discordant with impaired CFVR (2.0 ± 0.2). Intriguingly, endotype 1 showed lower DPVr (p &lt; 0.0001) and lower DPVh (p &lt; 0.0001) than controls with lower CFVR (p &lt; 0.0001) and lower CCFVR (p &lt; 0.0001) than controls. Moreover, both BMR and HMR were higher in endotype 1 than in controls (p = 0.001 and p &lt; 0.0001, respectively), suggesting structural microvascular remodeling. Conversely, endotype 2 was comparable to controls. A 13/32 (41%) patients in endotype 1 died in a follow up of 28 years and mortality rate was comparable to endotype 3 (14/31, 45%). However, CCFVR was &lt; 80 cm/s in all 13 deaths of endotype 1 (characterized by preserved CFVR). At multivariable analysis, CMD, DPVh &lt; 75 cm/s and CCFVR &lt; 80 cm/s were independent predictors of mortality. The inclusion of CCFVR &lt; 80 cm/s to models with clinical indicators of mortality better predicted survival, compared to only adding CMD or DPVh &lt; 75 cm/s (p &lt; 0.0001 and p = 0.03, respectively).ConclusionA normal CFVR could hide detection of microvasculopathy with high flow resistance and low flow velocities at rest. This microvasculopathy seems to be secondary to factors unrelated to HT (less rejections and more often diabetes). The combined use of CFVR and CCFVR provides more complete clinical and prognostic information on coronary microvasculopathy in HT.
Prognostic Implication of Longitudinal Changes of Left Ventricular Global Strain After Chemotherapy in Cardiac Light Chain Amyloidosis
Authors: Bak Minjung , Kim Darae , Choi Jin-Oh , Kim Kihyun , Kim Seok Jin , Jeon Eun-Seok 
Published: June 2022

AimCardiac involvement is the main prognostic determinant in AL amyloidosis. We sought to determine the prognostic significance of longitudinal change of left ventricular (LV) global longitudinal strain (GLS) in cardiac light chain (AL) amyloidosis patients undergoing chemotherapy.Methods and ResultWe retrospectively investigated 117 cardiac AL amyloidosis patients who underwent chemotherapy from 2005 to 2019. All patients underwent comprehensive 2D conventional transthoracic echocardiography at baseline and after completion of first-line chemotherapy. Speckle tracking analysis of images was performed offline. Absolute value of LV GLS was expressed as [LV GLS] and change of [LV GLS] after chemotherapy was expressed as Δ [LV GLS]. Clinical outcomes including cardiac response and all-cause mortality were analyzed.Baseline clinical and echocardiographic parameters were similar in patients with and without CR. Δ [LV GLS] significantly differed between the CR and non-CR groups (0.4 ± 2.8% in the CR group vs. −0.6 ± 2.5% in the non-CR group, P-value = 0.046). Δ [LV GLS] showed satisfactory predictive performance for all-cause mortality (cut-off value = 0.8%, AUC 0.643, 95% CI [0.537–0.748]). Adding Δ [LV GLS] to the Mayo stage + pre-chemotherapy [LV GLS] model showed incremental prognostic value (C-index: 0.637 vs. 0.708; Relative Integrated Discrimination Index 0.07, P-value = 0.003; Net Reclassification Improvement 0.54, P-value &lt; 0.001). Δ [LV GLS] showed good correlation with cardiac response (AUC 0.820, 95% CI [0.737–0.904]).ConclusionIn cardiac amyloidosis patients who underwent chemotherapy, longitudinal change of [LV GLS] after chemotherapy showed significant association with overall survival as well as cardiac response.