bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of sintilimab plus doxorubicin in advanced soft tissue sarcoma: A single-arm, phase II trial
Authors: Tian Zhichao , Dong Shuping , Zuo Wenli , Li Po , Zhang Fan , Gao Shilei , Yang Yonghao , Li Chao , Zhang Peng , Wang Xin , Wang Jiaqiang , Yao Weitao 
Published: December 2022

Background: Chemoimmunotherapy is safe and efficacious in treating many types of malignant tumors. However, clinical data demonstrating the effect of this combination treatment in patients with metastatic soft tissue sarcoma (STS) are currently limited. This study evaluated the safety and efficacy of a programmed cell death protein 1 (PD-1) inhibitor plus doxorubicin in patients with advanced STS who failed previous systemic therapy.Methods: This was a single-center, single-arm, open-label phase II trial. Patients with unresectable or metastatic STS who had previously failed systemic therapy were enrolled. Patients received up to six cycles of doxorubicin and sintilimab (a PD-1 inhibitor), while sintilimab treatment continued for up to 2 years. Primary outcomes were objective response rate (ORR) and safety. Univariate Cox proportional hazards model was used to analyze the relationship between clinicopathological parameters and progression-free survival (PFS).Results: A total of 38 patients (20 men and 18 women) were enrolled in this study. The overall ORR was 39.5%, disease control rate was 71.1%, and the median PFS was 4.5 months [95% confidence interval (CI), 3.0–8.5 months]. The adverse events (AEs) associated with the combined treatment were mild, manageable, and well-tolerated. The most common grade 3 or higher AEs were hematologic, including leukopenia (21.1%), anemia (18.4%), and thrombocytopenia (18.4%). Patients with undifferentiated pleomorphic sarcoma (UPS) or dedifferentiated liposarcoma had a significantly longer PFS than those with other pathological subtypes [hazard ratio (HR) = 0.42, 95% CI 0.21–0.83; p = 0.013]. There was no significant difference in the median PFS between patients who had previously received anthracycline-based chemotherapy and those who had not (HR = 0.74, 95% CI 0.34–1.58, p = 0.43).Conclusion: Sintilimab plus doxorubicin is a safe and promising treatment for patients with advanced STS who have failed previous systemic therapy (including anthracycline-based chemotherapy). The efficacy of this combination therapy in UPS and dedifferentiated liposarcoma is superior to that in other sarcomas.Clinical Trial Registration:https://www.chictr.org.cn, registration number: ChiCTR1900027009.
Loss to follow-up associated factors in patients with chronic pulmonary aspergillosis and its impact on the disease prognosis
Authors: Li Shaoqiang , Li Ya , Li Zhengtu , Yang Xin , Zhan Yangqing , Li Weilong , Lin Ye , Ye Feng 
Published: December 2022

ObjectivePulmonary aspergillosis is a rare but challenging pulmonary disease. The conditions of patients with chronic pulmonary aspergillosis (CPA) can be even more complicated. The mortality rate of CPA remains high, and the prognostic factors are not well established due to a high proportion of loss to follow-up. In this study, we aim to explore factors associated with loss to follow-up in CPA patients and their impact on the disease prognosis after withdrawing anti-fungal treatments.MethodsPatients with confirmed CPA, who were admitted to the Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Guangzhou Medical University from March 2017 to November 2019, were enrolled in this prospective study. The enrolled patients were followed up for 6 months after discharge. For loss to follow-up patients, the reasons for loss to follow-up and their prognosis after withdrawing anti-fungal treatments during loss to follow-up were recorded by telephone communication. Multivariate logistic regression analysis was performed to determine factors associated with loss to follow-up.ResultsThe 199 out of 298 screened patients were included in the study. Except for 67 cases with regular follow-up, the rest 132 cases were lost to follow-up. Factors, including age &gt; 60 years (OR = 2.036, P = 0.03), monthly income ≤ $583 (OR = 5.568, P = 0.0001), education ≤ 6 years (OR = 7.474, P = 0.0001), and non-local residence (OR = 5.893, P = 0.0001) were associated with the loss to follow-up according to multivariate logistic regression analysis. The most common reasons for loss to follow-up were economic factors and clinic visit distance. The overall case fatality rate (CFR) within 180 days in patients with regular follow-up and patients who stopped anti-fungal treatment during the loss to follow-up was 0% and 19.65%, respectively.ConclusionThe proportion of loss to follow-up in CPA patients remained high. Age (&gt;60 years), poor financial status, low education, and non-local residence were the key factors associated with the loss to follow-up in this study. Our study reveals the need to optimize the follow-up procedures and improve the patients understanding about the benefits and limitations of follow-up to reduce the CFR.
The spatial pattern and influencing factors of tourism eco-efficiency in Inner Mongolia, China
Authors: Wang Yuewei , Wu Xinyang 
Published: December 2022

BackgroundTourism eco-efficiency is a performance basis for evaluating green total factor productivity and sustainable development.ObjectiveThe objective of this study was to measure tourism eco-efficiency in Inner Mongolia and explore its influencing factors. The aim was to provide an accurate reference for improving the quality and efficiency of tourism in Inner Mongolia and promoting the sustainable development of the regional economy and society.MethodsTourism eco-efficiency in Inner Mongolia from 2009 to 2019 was calculated using a super-slacks-based measure (SBM) model with an undesirable output. The spatial variation function was used to explore the spatial evolution pattern of tourism eco-efficiency in Inner Mongolia, and the influencing factors of the spatial evolution were analyzed by geographically weighted regression.ResultsTourism eco-efficiency in Inner Mongolia is relatively low. Eco-efficiency values among cities in Inner Mongolia vary, and their distribution is not balanced. The structural eco-efficiency of tourism in Inner Mongolia has been consistent from 2009 to 2019. The degree of homogenization in the overall direction is relatively good. Furthermore, its spatial distribution form and internal structure evolution show a certain regularity and continuity. The pattern evolution of tourism eco-efficiency in Inner Mongolia is jointly driven by the economic level, environmental regulation, industrial structure, traffic conditions, resource endowment, and tourism reception facilities. These influencing factors show obvious spatial heterogeneity.ConclusionFrom the perspective of Inner Mongolia, the difference in the tourism eco-efficiency value from 2009 to 2019 was relatively large, but the number of effective areas in the efficiency frontier generally showed a fluctuating growth trend. The range parameters of tourism eco-efficiency showed a decreasing trend, and the spatial correlation effect of tourism eco-efficiency in Inner Mongolia showed a decreasing trend under the influence of structural and spatial differentiation.
Epidemiology and antimicrobial resistance of staphylococci other than Staphylococcus aureus from domestic animals and livestock in Africa: a systematic review
Authors: Ocloo Remous , Nyasinga Justin , Munshi Zubair , Hamdy Aisha , Marciniak Tessa , Soundararajan Manonmani , Newton-Foot Mae , Ziebuhr Wilma , Shittu Adebayo , Revathi Gunturu , Abouelfetouh Alaa , Whitelaw Andrew 
Published: December 2022

IntroductionStaphylococci other than Staphylococcus aureus (SOSA) in animals are becoming more pathogenic and antibiotic resistant and can potentially disseminate to humans. However, there is little synthesized information regarding SOSA from animals in Africa. This systematic review provides a comprehensive overview of the epidemiology and antimicrobial resistance of SOSA in companion animals (pets) and livestock in Africa.MethodThis systematic review (PROSPERO-CRD42021252303) was conducted according to the PRISMA guidelines, and 75 eligible studies from 13 countries were identified until August 2022. Three electronic databases (Pubmed, Scopus and Web of Science) were employed.ResultsThe frequently isolated SOSA were S. epidermidis, S. intermedius, S. pseudintermedius, S. xylosus, S. chromogenes, S. hyicus, M. sciuri, S. hominis, and S. haemolyticus. Thirty (40%) studies performed antibiotic susceptibility testing (AST). Penicillin (58%) and tetracycline (28%) resistance were most common across all SOSA with high rates of resistance to aminoglycosides, fluoroquinolones, and macrolides in some species. Resistance to last-resort antibiotics such as linezolid and fusidic acid were also reported. Limited data on strain typing and molecular resistance mechanisms precluded analysis of the clonal diversity of SOSA on the continent.ConclusionThe findings of this review indicate that research on livestock-associated SOSA in Africa is lacking in some regions such as Central and Western Africa, furthermore, research on companion animals and more advanced methods for identification and strain typing of SOSA need to be encouraged.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42021252303.
Adversity in Infancy and Childhood Cognitive Development: Evidence From Four Developing Countries
Authors: Manalew W. Samuel , Tennekoon Vidhura S. , Lee Jusung , O’Connell Bethesda , Quinn Megan 
Published: December 2022

Objectives: We investigated whether adverse experiences at age 1 (AE-1) affect the level of and change in cognition during childhood using harmonized data from four developing countries.Methods: Data included children born in 2001/2002 and were followed longitudinally in 2006/2007 and in 2009/2010 by Young Lives study in Ethiopia, India, Peru, and Vietnam. Childhood cognition was measured using the Peabody Picture Vocabulary Test (PPVT) at ages 5 (PPVT-5) and 8 (PPVT-8). We also examined the effect on a change in cognition between age 5–8 (PPVT-Change). The AE-1 scores were constructed using survey responses at age 1. The ordinary least squares regression was used for estimation.Results: We found that children with higher adversities as infants had lower cognition scores at ages 5 and 8. The change in cognition between the two ages was also generally smaller for those with severe adversities at infancy. The negative association between adversities and childhood cognition was strongest for India.Conclusion: The results provide policy relevant information for mitigation of undesirable consequences of early life adversities through timely interventions.
Frequency of Vitamin a Deficiency in Children Hospitalized for Pneumonia: An Integrative Review
Authors: Mendes Amanda De Conceição Leão , De Souza Ana Mayara Gomes , Nunes Aryelly Dayane Da Silva , Jerez-Roig Javier , Barbosa Isabelle Ribeiro 
Published: December 2022

Objective: To identify the frequency of vitamin A deficiency in children aged 6 months to 5 years hospitalized for pneumonia.Methods: An integrative literature review was carried out, where searches were made by two independent researchers, with no language limits or publication time in the databases PubMed, LILACS, Web of Science, Scopus and CINAHL, and in the gray literature—OpenGrey, Proquest and Google Scholar. In the eligibility phase, the screened studies were read in full and those that did not answer the research question were excluded. Methodological quality was assessed using the Downs &amp; Black (1998) checklist.Results: 1642 articles were identified, after all stages of screening and selection, 10 studies were included, of which 5 were longitudinal, 4 were intervention and 1 transversal. All studies identified subclinical vitamin A deficiency in children hospitalized with pneumonia; the highest frequency of subclinical vitamin A deficiency was 93.2%. All studies evaluated showed frequencies of subclinical vitamin A deficiency &gt;20%.Conclusion: There is a high frequency of subclinical vitamin A deficiency in children with pneumonia; these data need to be further explored in terms of their associations. For this reason, new studies that evaluate this topic are of fundamental importance.
General practice management of COPD patients following acute exacerbations: a qualitative study
Authors: Perera Bianca , Barton Chris , Osadnik Christian 
Published: December 2022

BackgroundExacerbations are the strongest risk factor for future exacerbations for patients living with chronic obstructive pulmonary disease (COPD). The period immediately following exacerbation is a high-risk period for recurrence and hospital admission, and is a critical time to intervene. GPs are ideally positioned to deliver this care.AimTo explore perceptions of GPs regarding the care of patients following exacerbations of COPD and to identify factors affecting the provision of evidence-based care.Design and settingA descriptive qualitative study was undertaken involving semi-structured, in-depth interviews with Australian GPs who volunteered to participate following a national survey of general practice care for COPD patients following exacerbations.MethodInterviews were conducted via the Zoom video conference platform, which were audio-recorded and transcribed verbatim. QSR NVivo was used to support data management, coding, and inductive thematic analysis.ResultsEighteen GPs completed interviews. Six key themes were identified: 1) GPs’ perceptions and knowledge in the management of COPD patients following exacerbation and admission to hospital; 2) pharmacological management; 3) consultation time; 4) communication between healthcare professionals; 5) access to other health services; and 6) patient compliance.ConclusionDelivery of post-exacerbation care to COPD patients is affected by GPs, patients, and health service-related factors. The care of COPD patients may be further improved by supporting GPs to overcome identified barriers.
Elaboração do novo currículo paulista em discussão
Authors: Miranda Nonato Assis de , Preto Paula Mansano 
Published: December 2022

A presente pesquisa buscou identificar os desafios encontrados pelos diretores e analisar as possibilidades de formação continuada que contribuem para a efetividade da prática profissional do diretor de escola. A abordagem qualitativa, complementada com a pesquisa bibliográfica e pesquisa de campo, por meio de Grupo de Discussão com cinco diretoras da rede municipal de ensino de Santo André/SP, delineou o desenvolvimento do trabalho. Os resultados mostram que as necessidades formativas devem ser consideradas pelas redes de ensino, viabilizando programas de formação continuada aos seus gestores. Nesse sentido, considera-se que as pautas formativas precisam ser flexíveis e adaptadas às questões emergentes e do cotidiano escolar. Ademais, entende-se que os momentos de escuta e a troca de experiência entre os pares contribuem efetivamente para o fortalecimento do trabalho dos diretores.
Demonstration of B-ion-implanted p-BaSi2/n-Si heterojunction solar cells
Authors: Aonuki Sho , Narita Shunsuke , Takayanagi Kaori , Iwai Ai , Yamashita Yudai , Toko Kaoru , Suemasu Takashi 
Published: December 2022

Abstract
The implantation of B atoms into BaSi2 epitaxial films grown by molecular beam epitaxy was performed to form p-type BaSi2 films. It was revealed by Raman spectroscopy that the ion-implantation damage induced in the implanted BaSi2 films was recovered by post-annealing at 600 °C or higher temperatures for 64 min. The hole concentration increased up to 3.1 × 1018 cm−3 at room temperature, indicating that B-ion-implanted p-BaSi2 films are applicable as a hole transport layer. The B-ion-implanted p-BaSi2/n-Si heterojunction solar cells showed rectifying current-voltage characteristics under AM1.5 G illumination and the internal quantum efficiency reached 72% at the wavelength of 900 nm. The conversation efficiency was 2.2%. These results open new routes for the formation methods of BaSi2 solar cells.
Penerapan Metode Prototype Dalam Merancang Purwarupa Pengaman Pintu Kandang Ternak Otomatis Berbasis Mikrokontroler ATMEGA 328P
Authors: Chandra Yudi Irawan , Irfan Irfan , Kosdiana Kosdiana , Riastuti Marti 
Published: December 2022

Cattle cage is a term that refers to a structure used to house farm animals or animal homes. The structure might be in the form of a container, a building, or something else entirely, depending on the type of animal being farmed. Because most cattle shed doors are slotted or padlocked, there is a high rate of theft from irresponsible individuals seeking to take livestock without permission. The primary objective of this research is to devise a security system capable of keeping cattle pens secure and free of thieves or burglars that cause livestock loss. The author chooses the Atmega 328 microcontroller because it features a Harvard architecture that separates program code and data memory to maximize work and parallelism. Additionally, this circuit may be connected to an Arduino Uno to create a variety of electronic circuits ranging from simple to complicated. LED control, helicopter control, servo drive control, and robot control can all be implemented by adding specific components. Thus, a prototype was created for an automatic door safety system that employs an infrared sensor to detect the presence of animals and automatically opens the entrance, locking it with a password and ringing a buzzer in front of the farmer's house if the password is incorrect. This tool was created to help minimize cattle losses due to theft.
Calidad de servicio y satisfacción de los usuarios
Authors: Huamaní Arone MBA José , Bejar Callañaupa Lic. Adm. Ingrith Estrella 
Published: December 2022

En esta investigación se desarrolló la calidad de servicio y la satisfacción de los usuarios de las empresas de transporte de pasajeros. Se formuló objetivo general, establecer el grado de relación que existe entre calidad de servicio y la satisfacción de los usuarios del servicio de transporte público de pasajeros interprovincial de la Ciudad de Challhuahuacho. Metodología utilizada en la investigación, es de tipo de investigación básica, nivel de los estudios correlacionales, diseño de investigación no experimental es sistemática y empírica, con una población infinita y a una muestra de 81 usuarios de transporte público de pasajeros en la ciudad de Challhuahuacho. Con los procesos de análisis estadístico y la revisión bibliográfico los resultados de la investigación de muestra la prueba de hipótesis de nivel relación positiva, que la calidad de servicios se asocia de manera lineal, quiere decir que estadísticamente significativa, media alta y directa con la satisfacción de los usuarios de transporte de pasajeros, los elementos tangibles, confiabilidad, capacidad de respuesta, seguridad y empatía se asocian de manera significativa, media alta y directa con la satisfacción de los usuarios de las empresas de transporte público de pasajeros.
LoTSS Jellyfish Galaxies. IV. Enhanced Star Formation on the Leading Half of Cluster Galaxies and Gas Compression in IC3949
Authors: Roberts Ian D. , Lang 郎 Maojin 茂锦 , Trotsenko Daria , Bemis Ashley R. , Ellison Sara L. , Lin Lihwai , Pan Hsi-An , Ignesti Alessandro , Leslie Sarah , van Weeren Reinout J. 
Published: December 2022

Abstract
With Mapping Nearby Galaxies at APO integral field spectroscopy, we present a resolved analysis of star formation for 29 jellyfish galaxies in nearby clusters, identified from radio continuum imaging taken by the Low Frequency Array. Simulations predict enhanced star formation on the “leading half” (LH) of galaxies undergoing ram pressure stripping, and in this work we report observational evidence for this elevated star formation. The dividing line (through the galaxy center) that maximizes this star formation enhancement is systematically tied to the observed direction of the ram-pressure-stripped tail, suggesting a physical connection between ram pressure and this star formation enhancement. We also present a case study on the distribution of molecular gas in one jellyfish galaxy from our sample, IC3949, using Atacama Large Millimeter/submillimeter Array CO J = 1 − 0, HCN J = 1 − 0, and HCO+
J = 1 − 0 observations from the ALMA MaNGA Quenching and Star Formation Survey. The H2 depletion time (as traced by CO) in IC3949 ranges from ∼1 Gyr in the outskirts of the molecular gas disk to ∼11 Gyr near the galaxy center. IC3949 shows a clear region of enhanced star formation on the LH of the galaxy where the average depletion time is ∼2.7 Gyr, in line with the median value for the galaxy on the whole. Dense gas tracers, HCN and HCO+, are only detected at the galaxy center and on the LH of IC3949. Our results favor a scenario in which ram pressure compresses the interstellar medium, promoting the formation of molecular gas that in turn fuels a localized increase of star formation.
ALMA Observations of CO Emission from Luminous Lyman-break Galaxies at z = 6.0293–6.2037
Authors: Ono Yoshiaki , Fujimoto Seiji , Harikane Yuichi , Ouchi Masami , Vallini Livia , Ferrara Andrea , Shibuya Takatoshi , Pallottini Andrea , Inoue Akio K. , Imanishi Masatoshi , Shimasaku Kazuhiro , Hashimoto Takuya , Lee Chien-Hsiu , Sugahara Yuma , Tamura Yoichi , Kohno Kotaro , Schramm Malte 
Published: December 2022

Abstract
We present our new Atacama Large Millimeter/submillimeter Array (ALMA) observations targeting CO(6–5) emission from three luminous Lyman-break galaxies (LBGs) at z
spec = 6.0293–6.2037 found in the Subaru/Hyper Suprime-Cam survey, whose [O iii] 88 μm and [C ii] 158 μm emissions have been detected with ALMA. We find a marginal detection of the CO(6–5) line from one of our LBGs, J0235–0532, at the ≃4σ significance level and obtain upper limits for the other two LBGs, J1211–0118 and J0217–0208. Our z = 6 luminous LBGs are consistent with the previously found correlation between the CO luminosity and the infrared luminosity. The unique ensemble of the multiple far-infrared emission lines and underlying continuum fed to a photodissociation region model reveals that J0235–0532 has a relatively high density of hydrogen nuclei n
H that is comparable to those of low-z (U)LIRGs, quasars, and Galactic star-forming regions with high n
H values, while the other two LBGs have lower n
H consistent with local star-forming galaxies. By carefully taking account of various uncertainties, we obtain constraints on total gas mass and gas surface density from their CO luminosity measurements. We find that J0235–0532 is located below the Kennicutt–Schmidt (KS) relation, comparable to the z = 5.7 LBG, HZ10, previously detected with CO(2–1). Combined with previous results for dusty starbursts at similar redshifts, the KS relation at z = 5–6 is on average consistent with the local one.