bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity
Authors: Alfonso‐Herrera Luis A. , Rosete‐Luna Sharon , Hernández‐Romero Delia , Rivera‐Villanueva José M. , Olivares‐Romero José L. , Cruz‐Navarro J. Antonio , Soto‐Contreras Anell , Arenaza‐Corona Antonino , Morales‐Morales David , Colorado‐Peralta Raúl 
Published: September 2022

AbstractAlthough it is known that the first case of cancer was recorded in ancient Egypt around 1600 BC, it was not until 1917 during the First World War and the development of mustard gas that chemotherapy against cancer became relevant; however, its properties were not recognised until 1946 to later be used in patients. In this sense, the use of metallopharmaceuticals in cancer therapy was extensively explored until the 1960s with the discovery of cisplatin and its anticancer activity. From that date to the present, the search for more effective, more selective metallodrugs with fewer side effects has been an area of continuous exploration. Efforts have led to considering a wide variety of metals from the periodic table, mainly from thed‐block, as well as a wide variety of organic ligands, preferably with proven biological activity. In this sense, various research groups have found an ideal binder in Schiff bases, since their raw materials are easily accessible, their synthesis conditions are friendly and their denticity can be manipulated. Therefore, in this review, we have explored the anticancer and antitumor activity reported in the literature for coordination complexes ofd‐block metals coordinated with tridentate Schiff bases (O N O and O N N) derived from salicylaldehyde. For this work, we have used the main scientific databases CCDC® and SciFinder®.
Efficacy and potential resistance mechanisms of afatinib in advanced non–small cell lung cancer patients with EGFR G719X/L861Q/S768I
Authors: Pang Lan‐Lan , Gan Jia‐Di , Tan Jia‐Rong , Huang Yi‐Hua , Liao Jun , Liang Wei‐Ting , Deng Peng‐Bo , Fang Wen‐Feng 
Published: September 2022

BackgroundAfatinib is the only currently approved EGFR‐tyrosine kinase inhibitors for advanced non–small cell lung cancer (NSCLC) patients with EGFR G719X/L861Q/S768I. However, there are limited real‐world data concerning the benefits and resistance mechanisms of afatinib in patients with these nonclassical mutations. To fill this gap, the present study was conducted.MethodsAll NSCLC patients treated with afatinib were screened, and patients with EGFR G719X/L861Q/S768I were enrolled into the analysis. Either tumor tissue or blood specimens were detected by the commercial next‐generation sequencing (NGS) panels or amplification‐refractory mutation system (ARMS)‐polymerase chain reaction (PCR) to figure out the mutation genotype.ResultsA total of 106 advanced NSCLC patients with EGFR G719X/L861Q/S768I received afatinib treatment. The benefits of afatinib exhibited heterogeneity in different mutation genotypes. Notably, at baseline, NGS testing was performed in 59 patients, and TP53 was the most frequently coexisting mutation. Patients with TP53 mutations obtained fewer survival benefits than those with TP53 wild‐type. A total of 68 patients ultimately experienced progression, and 27 patients received NGS testing to clarify the potential resistance mechanisms. EGFR‐T790M, CDK4 amplification, FGFR1 amplification, PIK3CA, MET amplification, RET fusions, HER2, and BRAF mutations were identified in three (11.1%), three (11.1%), three (11.1%), three (11.1%), three (11.1%), one (3.7%), one (3.7%), and one (3.7%) of the cases, respectively. Five patients underwent ARMS‐PCR testing for detecting EGFR‐T790M mutation, and only one patient was T790M‐positive.ConclusionsThe present study elucidated the differential benefits of afatinib within different mutation genotypes and first revealed the spectrum of potential resistance mechanisms in patients with EGFR G719X/L861Q/S768I. The results of this study may provide practical clinical information that can guide optimal treatment in this setting.
Hierarchical TS‐1 Through Ammonium Fluoride Etching
Authors: Akkal Thilali , Soualah Ahcène , Morisset Sophie , Rousseau Julie , Chaouati Nourrdine , Sachse Alexander 
Published: September 2022

AbstractThe impact of the NH4F etching on the textural and catalytic properties of TS‐1 was investigated. Two TS‐1 with different crystal sizes, i. e. 200 and 100 nm; were achieved, with different textural properties as inferred from nitrogen physisorption isotherms at 77 K, mercury porosimetry, powder X‐ray diffraction patterns and transmission electron microscopy. The generation of larger mesopores within the parent samples was observed together with a reduction of the coherent crystal size (CCS) upon NH4F etching. The generation of secondary porosity further did not result in an alteration of the Si/Ti ratio, allowing to compare the catalytic outcomes of the samples as a function of the textural properties. It was found that the methyl‐phenyl sulfide (MPS) conversion kinetics importantly depend on the textural properties of the catalysts. The initial velocity was found to increase linearly with the reduction of the CCS until reaching a plateau, indicating that diffusion limitation occur up to a CCS of approximately 100 nm. Likewise, mono‐ and di‐oxidation product selectivity was governed by diffusion issues.
Bioinspired Asymmetric Surface Property of Functionalized Mesh to Maximize the Efficiency of Fog Harvesting
Authors: El‐Maghraby Hesham F. , Alhumaidi Afra , Alnaqbi Mohamed A. , Sherif Mohsen , Tai Yanlong , Hassan Fathy , Greish Yaser E. 
Published: September 2022

AbstractWater scarcity in many countries on earth has inspired scientists to seek other resources of freshwater. Desalination, as one of the most commonly used approaches, is energy consuming and has faced a number of environmental difficulties. On the other hand, natural species, plants and insects, have developed their own modalities of securing fresh water by harvesting it from the atmospheric fog and humidity. The current study investigates the fabrication of bioinspired mesh membranes for fog harvesting. The mesh membranes are coated using a simple dip coating procedure with various extents of TiO2‐PMMA hybrid structure that provides a composite structure of mixed degrees of wettability. Depending on the initial concentration of PMMA, partially and completely covered mesh membranes were prepared. The coated mesh membranes resemble Spider silk in their architecture and in their surface topography to other desert natural species. A homogeneous distribution of the TiO2 NPs within the PMMA coating was reflected on a spectrum of hydrophilic and hydrophobic domains. The fabricated mesh membranes are durable and have been shown to harvest water from fog at a rate of 32–45 L/m2 per hour, hence securing a sustainable supply of fresh water for all aspects of life.
Tailoring Room Temperature Ferromagnetism and Observation of Electrolyte of Widest Potential Window in Gd0.75Se Nano Particles
Authors: Ariponnammal S. , Shalini S. , Anusha S. 
Published: September 2022

AbstractUniformly distributed rectangular nanoparticles with some triangular particles of gadolinium selenide (Gd0.75Se) are prepared by the chemical precipitation method. It crystallizes in a cubic structure. It shows paramagnetic behavior along with interesting weak ferromagnetism at room temperature. In the present study, the cyclic voltammogram of electrolyte of Gd0.75Se shows pseudocapacitive behavior with a wider potential window of 3.75 V. The wider potential window electrolyte enhances applications in the super capacitor field for energy storage. The specific capacitance is 21 F g−1, and the energy density is 146 Wh kg−1. The observed high power density is 4.2 kW kg−1. The energy gap is 1.55 eV. A study of photoluminescence confirms the presence of native point defects.
Green innovation peer effects in common institutional ownership networks
Authors: Wu Xiaohui , Li Yumin , Feng Chong 
Published: September 2022

AbstractAs an important breakthrough in coordinating economic, social, and ecological benefits, green innovation has received wide attention from governments, firms, and the public. However, existing studies mainly explored the economic factors influencing firms' green innovation while neglecting social factors. This study took common institutional ownership as the research perspective to explore whether firms' green innovation decisions are affected by their peers. Using a sample of Chinese A‐share listed firms from 2003 to 2019, this paper found that firms imitate their peers' green innovation in common institutional ownership networks and exhibit green innovation peer effects. Mechanism testing revealed that “voting with hands” through common institutional ownership helps firms obtain green innovation information (information‐based imitation), while “voting with feet” through common institutional ownership helps firms maintain a competitive awareness of green innovation (rivalry‐based imitation), thereby contributing to green innovation peer effects in common institutional ownership networks. Heterogeneity analysis showed that firms with greater financing constraints and lower levels of risk‐taking are more likely to imitate their peers' green innovation. Moreover, firms only regard peers with similar industry status and identical property rights as imitation targets in common institutional ownership networks, thereby following “the imitation law of closer preference.” An analysis of economic consequences revealed that green innovation peer effects in common institutional ownership networks are not strategic behaviors of “quantity over quality,” with imitation contributing to improving firm value. This paper enriches existing research on the influencing factors of green innovation and provides a new reference for promoting sustainable development.
Design and Investigation of a Photocatalytic Setup for Efficient Biotransformations Within Recombinant Cyanobacteria in Continuous Flow
Authors: Valotta Alessia , Malihan‐Yap Lenny , Hinteregger Kerstin , Kourist Robert , Gruber‐Woelfler Heidrun 
Published: September 2022

AbstractPhoto‐ and biocatalysis show many advantages as more sustainable solutions for the production of fine chemicals. In an effort to combine the benefits and the knowledge of both these areas, a continuous photobiocatalytic setup was designed and optimized to carry out whole‐cell biotransformations within cells of the cyanobacteriumSynechocystissp. PCC 6803 expressing the gene of the ene‐reductase YqjM fromB. subtilis. The effect of the light intensity and flow rate on the specific activity in the stereoselective reduction of 2‐methyl maleimide was investigated via a design‐of‐experiments approach. The cell density in the setup was further increased at the optimal operating conditions without loss in specific activity, demonstrating that the higher surface area/volume ratio in the coil reactor improved the illumination efficiency of the process. Furthermore, different reactor designs were compared, proving that the presented approach was the most cost‐ and time‐effective solution for intensifying photobiotransformations within cyanobacterial cells.
Agreement of steroid profiles in Athlete Biological Passport residues and corresponding serum samples
Authors: König Simon , Rzeppa Sebastian , Thieme Detlef , Keiler Annekathrin M. 
Published: September 2022

AbstractThe steroid module of the Athlete Biological Passport (ABP) is based on the analysis of six endogenous steroids in urine samples and a Bayesian statistical approach. However, the urinary steroid concentrations may be affected by confounders like microbial degradation, possible co‐administration of diuretics as masking agents, insufficient conjugate hydrolysis or UGT2B17 gene polymorphisms affecting glucuronidation. Therefore, it can be helpful to use other matrices (ABP blood and serum samples) to quantify steroids and thereby support noticeable deviations in the Athlete Biological Passport, for example, abnormally increased urinary testosterone/epitestosterone (T/E) ratios. Aim of the study was to investigate the feasibility to re‐use plasma obtained from athlete ABP blood samples for measuring a steroid profile. Therefore, testosterone, androstenedione, cortisol and cortisone were quantified in 36 intra‐individual matching ABP blood and serum samples. The steroid levels measured in both matrices showed a high agreement indicating a good stability uninfluenced by storage temperature and duration. Our results pointed out the possibility to expand the athlete ABP blood analysis for steroid profiling.
Sexual selection, feather wear, and time constraints on the pre‐basic molt explain the acquisition of the pre‐alternate molt in European passerines
Authors: Cuervo José J. , Morales Judith , Soler Juan J. , Moreno Juan 
Published: September 2022

AbstractAvian feathers need to be replaced periodically to fulfill their functions, with natural, social, and sexual selection presumably driving the evolution of molting strategies. In temperate birds, a common pattern is to molt feathers immediately after the breeding season, the pre‐basic molt. However, some species undergo another molt in winter‐spring, the pre‐alternate molt. Using a sample of 188 European passerine species, Bayesian phylogenetic mixed models, and correlated evolution analyses, we tested whether the occurrence of the pre‐alternate molt was positively associated with proxies for sexual selection (sexual selection hypothesis) and nonsexual social selection (social selection hypothesis), and with factors related to feather wear (feather wear hypothesis) and time constraints on the pre‐basic molt (time constraints hypothesis). We found that the pre‐alternate molt was more frequent in migratory and less gregarious species inhabiting open/xeric habitats and feeding on the wing, and marginally more frequent in species with strong sexual selection and those showing a winter territorial behavior. Moreover, an increase in migratory behavior and sexual selection intensity preceded the acquisition of the pre‐alternate molt. These results provide support for the feather wear hypothesis, partial support for the sexual selection and time constraints hypotheses, and no support for the social selection hypothesis.
3D hierarchical porous carbon foams as high‐performance free‐standing anodes for microbial fuel cells
Authors: Li Huidong , Zhang Lu , Wang Ruiwen , Sun Jinzhi , Qiu Yunfeng , Liu Shaoqin 
Published: September 2022

AbstractMicrobial fuel cells (MFCs) that can directly convert chemical energy of organic matter into electrical energy are expected to continuously obtain energy from wastewater. However, the practical application of MFCs is still limited by unsatisfactorily low power output due to low bacterial loading capacity and relatively poor extracellular electron transport (EET) efficiency between anode and electrochemically active biofilm. Herein, hierarchical porous carbon foams (HPCFs) prepared by pyrolyzing nanoscale Fe‐MIL‐88B‐NH2 modified seitan composite were developed as 3D free‐standing MFC anodes. Its marcoporous structure and good biocompatibility favor the bacterial adhesion, while the N‐doped carbon skeleton, abundant mesopores and iron ions boost the bacteria‐electrode charge transfer efficiency. As a result, the HPCF anodes equipped MFCs deliver a maximum power density of 11.21 W m−3 and a current density of 23.11 A m−3, outperforming the most previously reported 3D porous anodes. This study provides a new idea for the design of anodes for high‐performance MFCs.image
A comprehensive framework for solar panel technology selection: A BWM‐ MULTIMOOSRAL approach
Authors: Shayani Mehr Pegah , Hafezalkotob Ashkan , Fardi Keyvan , Seiti Hamidreza , Movahedi Sobhani Farzad , Hafezalkotob Arian 
Published: September 2022

AbstractConcerning the overwhelming advantages of solar energy, controlling and exploiting solar energy by using solar panels is one of the main fields of research in the domain of renewable energy. The choice of solar panel technology is highly significant to exploit as much energy as possible. In this paper, the main goal is to select the best technology for solar panels by investigating nine technologies from the first, second, and third generations of solar panels. Moreover, five sustainable criteria of electrical, mechanical, economic, technical, and climate, and 20 subcriteria are given for making decision analysis. Then, the best–worst method is employed according to the experts' opinions for weighting the criteria and for comparing the ranking of the solar energy technologies a framework based on the MULTIMOOSRAL multiple criteria decision‐making method is proposed. Finally, sensitivity analysis will be conducted on the ranking of the technologies. By exploiting the proposed methodology, CIS/CIGS and Perovskite Solar cell are ranked 1 and 2 as the best solar panel technologies for the selected locations.
Hippocampal spatial view cells for memory and navigation, and their underlying connectivity in humans
Authors: Rolls Edmund T. 
Published: September 2022

AbstractHippocampal and parahippocampal gyrus spatial view neurons in primates respond to the spatial location being looked at. The representation is allocentric, in that the responses are to locations “out there” in the world, and are relatively invariant with respect to retinal position, eye position, head direction, and the place where the individual is located. The underlying connectivity in humans is from ventromedial visual cortical regions to the parahippocampal scene area, leading to the theory that spatial view cells are formed by combinations of overlapping feature inputs self‐organized based on their closeness in space. Thus, although spatial view cells represent “where” for episodic memory and navigation, they are formed by ventral visual stream feature inputs in the parahippocampal gyrus in what is the parahippocampal scene area. A second “where” driver of spatial view cells are parietal inputs, which it is proposed provide the idiothetic update for spatial view cells, used for memory recall and navigation when the spatial view details are obscured. Inferior temporal object “what” inputs and orbitofrontal cortex reward inputs connect to the human hippocampal system, and in macaques can be associated in the hippocampus with spatial view cell “where” representations to implement episodic memory. Hippocampal spatial view cells also provide a basis for navigation to a series of viewed landmarks, with the orbitofrontal cortex reward inputs to the hippocampus providing the goals for navigation, which can then be implemented by hippocampal connectivity in humans to parietal cortex regions involved in visuomotor actions in space. The presence of foveate vision and the highly developed temporal lobe for object and scene processing in primates including humans provide a basis for hippocampal spatial view cells to be key to understanding episodic memory in the primate and human hippocampus, and the roles of this system in primate including human navigation.
Quality of death certificates completion for COVID‐19 cases in the southeast of Iran: A cross‐sectional study
Authors: Alipour Jahanpour , Karimi Afsaneh , Miri‐Aliabad Ghasem , Baloochzahei‐Shahbakhsh Farzaneh , Payandeh Abolfazl , Sharifian Roxana 
Published: September 2022

AbstractBackground and AimDeath certificate (DC) data provides a basis for public health policies and statistics and contributes to the evaluation of a pandemic's evolution. This study aimed to evaluate the quality of the COVID‐19‐related DC completion.MethodsA descriptive‐analytical study was conducted to review a total of 339 medical records and DCs issued for COVID‐19 cases from February 20 to September 21, 2020. A univariate analysis (χ2 as an unadjusted analysis) was performed, and multiple logistic regression models (odd ratio [OR] and 95% confidence interval [CI] as adjusted analyses) were used to evaluate the associations between variables.ResultsErrors in DCs were classified as major and minor. All of the 339 examined DCs were erroneous; more than half of DCs (57.8%) had at least one major error; all of them had at least one minor error. Improper sequencing (49.3%), unacceptable underlying causes of death (UCOD) (33.3%), recording more than one cause per line (20.1%), listing general conditions instead of specific terms (11.2%), illegible handwriting (8.3%), competing causes (6.2%), and mechanisms (3.8%) were most common major errors, respectively. Absence of time interval (100%), listing mechanism allying with UCOD (51.6%), using abbreviations (45.4%), missing major comorbidities (16.5%), and listing major comorbidities in part I (16.5%) were most common minor errors, respectively.ConclusionThe rate of both major and minor errors was high. Using automated tools for recording and selecting death cause(s), promoting certifiers' skills on DC completion, and applying quality control mechanisms in DC documentation can improve death data and statistics.
CFD‐based analysis of entropy generation due to mean and fluctuating fields during turbulent natural convection in a square enclosure
Authors: Said Khaled , Ouadha Ahmed , Sabeur Amina 
Published: September 2022

AbstractThe current study aims to numerically investigate the entropy generation during the natural convection flow of air in a square cavity. The governing equations for the conservation of mass, momentum, energy, and turbulence are solved using a control volume‐based technique employing the commercial code Fluent. Runs have been performed for both laminar and turbulent flow regimes by varying the Rayleigh number (Ra) from 103 to 1010. On the other hand, various viscous distribution coefficients (ϕ = 10−4, 10−3, and 10−2) and constant Prandtl number (Pr = 0.71) were considered. Given the conflicting perspectives in the literature regarding the entropy generation under turbulent regimes, more research is needed to better understand the impact that the fluctuating flow has on entropy production. The four terms of entropy generation inherent to turbulent natural convection (entropy generation due to dissipation in the mean and the fluctuating velocity fields in addition to the heat flux due to the mean and the fluctuating temperature) are computed in the present work and compared to calculations based on only mean values of temperature and velocity gradients. It was found that taking into account the fluctuating terms of temperatures and velocities augment the total entropy generation by 10.10%, 14.43%, and, 17.70%, up to 32.60%, respectively, for Ra = 5 × 108, Ra = 109, Ra = 1.58 × 109, and Ra = 1010. The gain shows the tendency to increase with the Rayleigh number. Thus, the fluctuating terms cannot be neglected particularly for high Rayleigh numbers. Furthermore, unlike entropy production due to the mean flow field, numerical outcomes reveal that the generated irreversibilities due to fluctuating flow are located around the upper hot and the lower cold corners of the heated walls. In addition, a numerical relationship between the first and the second laws of thermodynamics has been derived. A promising result that emerged from this study has shown that the Nusselt number and therefore the first law of thermodynamics is sufficient to estimate the heat part of entropy generation without the necessity of using the second law.