bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of Firocoxib and Its Related Substances in Bulk Drug Substance Batches of Firocoxib by a High-Speed Reversed-Phase HPLC Method With a Short Fused-Core Biphenyl Column
Authors: Wang Lin , Rustum Abu M 
Published: December 2022

Abstract
Firocoxib is a nonsteroidal anti-inflammatory drug. It provides control of postoperative pain and inflammation associated with soft tissue and orthopedic surgery in dogs, and control of pain and inflammation associated with osteoarthritis in horses. A high-speed stability-indicating reversed-phase high-performance liquid chromatography method was developed to determine firocoxib and its related substances in bulk batches of firocoxib drug substance. Firocoxib was dissolved in neat acetonitrile (ACN) and analyzed on a short HALO (fused-core) biphenyl column (30 × 4.6 mm i.d., 2.7-μm particle size) at flow rate of 2.5 mL/min. Column temperature was maintained at 50°C. Mobile phase A is composed of 0.1% of H3PO4 in water and mobile phase B is composed of ACN. Analytes were detected with UV detection at 240 nm and quantitated against an external reference standard. Firocoxib and its related compounds were adequately separated within 4 min by a gradient elution. The method was validated for specificity, linearity, accuracy, precision and robustness according to method validation guidelines described in The International Conference on Harmonization. The validation data demonstrated that this method is sensitive, accurate, robust, specific and stability-indicating.
A Life-Course Perspective on Older Workers in Workplaces Undergoing Transformative Digitalization
Authors: Komp-Leukkunen Kathrin 
Published: December 2022

AbstractWorkplaces are digitalizing, which leaves many older individuals with the choice between upskilling and early retirement. How they approach this choice influences their financial well-being, the size of the workforce, and the financial sustainability of pension schemes. The present article explores how the life-course perspective can be used to explore the situation of older workers in workplaces undergoing transformative digitalization. The life-course perspective suggests that the transformative digitalization of workplaces does not change what life events older workers encounter. However, it modifies how the events affect older workers and their capabilities for striking a work-life balance. Additionally, digitalization changes life-course structures. It can lead to earlier or later retirement, which changes the length of the life phases of middle age and old age—and possibly creates new social inequalities in life courses. The effects of transformative digitalization on older workers vary across cohorts and countries, which is typical for the principle of anchoring life courses in time and place. Future research can use the present article as a guideline for which concepts may be useful in studies on older workers in digitalizing workplaces.
Channel encroachment strategy through pure online or combined offline retailing
Authors: Chen S , Zhao R 
Published: December 2022

Abstract
With the rise of e-commerce, an increasing number of retailers concentrate on the online channel to sell their products (strategy O), while some retailers select online and offline combined retailing. That is, the retailers introduce an offline experience store in addition to their online channels (strategy B). However, there is little literature on which strategies are better when a retailer’s intrusion is considered. This paper constructs a competitive system in which the incumbent is a well-established pure online retailer and the new entrant will decide which strategy to select, strategy O or strategy B. The hotelling model is applied to represent the competitive market of both retailers through consumers’ asymmetrical preference for products, and Nash games under two strategies are built. Through comparing equilibrium solutions, we show that when consumers prefer the incumbent’s product, online and offline retailing is an effective strategy for the new entrant to compete with the incumbent. Meanwhile, the incumbent’s advantage does not always benefit him. Consumers’ asymmetrical preference for products may intensify the competition between them and hurt their profits, but the new entrant can benefit from providing offline retailing under most cases.
Potential for Anthropogenic Fin Damage to Affect Individual Responses to Prey in Bluegill Sunfish (Lepomis macrochirus): A New Hypothesis for Kinematic Studies
Authors: Cohen H E , Ray W , Hawkins O H , Kane E A 
Published: December 2022

Synopsis
In fishes, damage to important morphological structures such as fins through natural damage and anthropogenic factors can have cascading effects on prey capture performance and individual fitness. Bluegill sunfish (Lepomis macrochirus) are a common freshwater species in North America, are a model organism for performance studies, and often experience natural injuries. We opportunistically sampled two populations of fish in the lab to generate a hypothesis for the effect of sub-lethal fin damage resulting from the capture technique on kinematic performance during prey capture in bluegill. We found no statistical differences in mean prey capture kinematics or predator accuracy, but damaged fish used more variable kinematics and more readily struck at non-prey items. We suggest that a reduction in stability and individual consistency occurs as a result of fin damage. This difference could have consequences for higher-order ecological interactions such as competitive ability, despite a lack of apparent performance cost at the individual level, and deserves consideration in future studies of prey capture performance in fish.
Balenciaga, licensee of Maison Vionnet
Authors: Balda Ana 
Published: December 2022

Abstract
Cristóbal Balenciaga’s initial period in Spain (1917–1936), when he was working to develop himself as a couturier and consolidate his business in the luxury sector, is less known than his Parisian period (1937–1968), due to the scarcity of available information. This article analyses the designer as a buyer of haute couture licenses during that initial period. His biographers claim that in the early years of his professional development Balenciaga would attend to the presentations of prestigious French Maisons where he acquired pieces that he later sold in his establishment in San Sebastián, and that he studied to improve his own technique. Among these Maisons is that of Madeleine Vionnet. However, the restrictive licensing policy applied by the French couturière, puts in doubt the idea that Balenciaga had once been authorized to acquire pieces from her collections. Based on research in the archives of the Musée des Arts Décoratifs, the Bibliothèque Historique de la Ville de Paris and the Archives de Paris, and in the Spanish, French and North American press published between 1920 and 1930, this article provides new findings that confirm the existence of just such a commercial relationship. It reveals when it emerged, specifies which Vionnet pieces Balenciaga acquired and studies the influence of Vionnet’s technique and aesthetics on some of the Basque couturier’s creations prior to his establishment in Paris.
New light on the art collection of Andrea Menichini
Authors: Crack Peter 
Published: December 2022

Abstract
Among the seventeenth-century state papers held at the National Archives at Kew is a list, dated 1670, of fifty-four works of art that were for sale at that time in Italy. The document was penned by John Dodington, an English diplomat who had recently taken up a post in Venice. Despite providing a wealth of detail on the objects for sale – several of which he ascribed to some of Europe’s most illustrious painters and sculptors from the fifteenth to the seventeenth centuries – Dodington neglected to name the owner of this impressive assemblage. This article establishes the identity of the seller, recounts the history of his collection, and traces the ultimate fate of some of his possessions.
Provider beliefs in effectiveness and recommendations for primary HPV testing in 3 health-care systems
Authors: Kruse Gina R , Lykken Jacquelyn M , Kim Eric J , Haas Jennifer S , Higashi Robin T , Atlas Steven J , McCarthy Anne Marie , Tiro Jasmin A , Silver Michelle I , Skinner Celette S , Kamineni Aruna 
Published: December 2022

Abstract
In 2018, the US Preventive Services Task Force endorsed primary human papillomavirus testing (pHPV) for cervical cancer screening. We aimed to describe providers’ beliefs about pHPV testing effectiveness and which screening approach they regularly recommend. We invited providers who performed 10 or more cervical cancer screens in 2019 in 3 healthcare systems that had not adopted pHPV testing: Kaiser Permanente Washington, Mass General Brigham, and Parkland Health; 53.7% (501/933) completed the survey between October and December 2020. Response distributions varied across modalities (P &lt; .001), with cytology alone or cotesting being more often viewed as somewhat or very effective for 30- to 65-year-olds compared with pHPV (cytology alone 94.1%, cotesting 96.1%, pHPV 66.0%). In 21- to 29-year-olds, the pattern was similar (cytology alone 92.2%, 64.7% cotesting, 50.8% pHPV). Most providers were either incorrect or unsure of the guideline-recommended screening interval for pHPV. Educational efforts are needed about the relative effectiveness and recommended use of pHPV to promote guideline-concordant care.
Reconstruction using low-porosity β-tricalcium phosphate for a chondroblastoma in the proximal humeral epiphysis
Authors: Sakamoto Akio , Noguchi Takashi , Matsuda Shuichi 
Published: December 2022

Abstract
Chondroblastoma is a locally aggressive tumor, commonly occurring in the epiphysis of long bones. Damage after curettage at the joint surface can occur. Low porosity β-tricalcium phosphate (β-TCP) blocks are characterized by their high compression resistance. Reconstruction in which low-porosity β-TCP blocks are used as a strut have been reported for bone tumors around the knee. In the current report, a 13-year-old female with a chondroblastoma that extended to the subchondral bone of the proximal humeral epiphysis was treated with curettage and strut reconstruction using low-porosity β-TCP blocks. The implanted β-TCP blocks were incorporated without damage or shoulder dysfunction. Application of the strut reconstruction method using low-porosity β-TCP blocks is suitable for a chondroblastoma of the epiphysis in the humerus.
Reoperation 10 years after Nuss procedure failed: Wung procedure combined with Wenlin procedure
Authors: Wang Wenlin , Long Weiguang , Liu Yang , Cai Bin , Luo Juan 
Published: December 2022

AbstractAfter the failure of Nuss procedure for pectus excavatum, the risk of reoperation is high, and it is difficult and challenging. Recently, we performed the reoperation for a patient who had failed Nuss procedure 10 years ago. During the operation, Wung procedure and Wenlin procedure were combined to be used and satisfactory results were obtained.
Sensing suffering: on common-sense and compassion in the legal imagination and recognition of torture
Authors: Cakal Ergün 
Published: December 2022

Abstract
Emotion and imagination are central to recognising another’s suffering—aiding in evaluating what is seen, heard, and registered. Tending to torture’s adjudication, this article connects the ‘law and torture’ jurisprudence to two areas of ‘law and emotion’ scholarship, namely common-sense and compassion (and, with the latter, empathy).
COVID-19 Outbreak in A Forward-Deployed Expeditionary Military Command: A Retrospective Review on Preventative Measures and Outbreak Characteristics
Authors: Nardi Sean , McGrath Matthew , Wido Daniel , Murray Lauren , Byrne Brendan , Delk Gerald 
Published: December 2022

ABSTRACT

Background
An outbreak of coronavirus disease 2019 (COVID-19) occured within a land based 2,000-member cohort stationed on a remote air base in the Middle East from June to August 2020. We retrospectively reviewed base characteristics and mitigation measures instituted during the outbreak. We also reviewed documentation on the individuals that were either quarantined or placed in isolation and provide data on demographics, real-time reverse transcriptase polymerase chain reaction (rRT-PCR) results, occupation, and workdays lost.

Results
During the reporting period, 46 individuals or 3.84% of the population had a positive COVID-19 rRT-PCR test. Aviation personnel represented 50% of the COVID-19 positive tests. Sixteen percent of health care personnel were tested positive. Overall, 10% of personnel were placed in isolation or quarantine, resulting in the loss of 1,552 workdays.

Conclusions
The data show a disproportionate impact on healthcare workers and personnel involved in aviation operations. The purpose of this study is 2-fold: to describe the characteristics of the outbreak and to highlight the effectiveness of mitigation measures implemented to control it during military operations. This study may serve to inform medical professionals and military leaders in the management of a similar outbreak in a congregate living setting.
The radial profile of dust grain size in the protoplanetary disc of DS Tau
Authors: Li Dafa , Liu Yao , Wang Hongchi , Wang Yao , Ma Yuehui 
Published: December 2022

ABSTRACT
How do dust grains in protoplanetary discs overcome rapid radial drift and grow from micron size particles to planets is not well understood. The key is to search for evidence of dust accumulation and growth as a function of radius in the disc. We investigate the radial profile of grain size in the DS Tau disc by fitting multiband ALMA observations with self-consistent radiative transfer models. The best-fit grain sizes range from centimeters in the inner disc down to ${\sim }\, 30\, \mu {\rm m}$ in the outer regions. Such an inside-out decreasing tendency is consistent with theories of dust evolution. Based on the best-fit model, we find that dust of ${\sim }\, 2$ Jupiter masses has been depleted within the gap. By taking the gas-to-dust mass ratio into account, the lost mass is enough to form the 3.5 Jupiter mass planet inferred by literature hydrodynamic simulations. Moreover, our modelling also indicates that at the interface region between the gap and the ring, the grain size profile shows a discontinuity, with its amplitude dependent on the dust model adopted in the radiative transfer analysis. Future multiwavelength observations at higher angular resolutions are required to better constrain the grain size and its variation in the vicinity of disc substructures.
Dual-corona Comptonization model for the type-b quasi-periodic oscillations in GX 339-4
Authors: Peirano Valentina , Méndez Mariano , García Federico , Belloni Tomaso 
Published: December 2022

ABSTRACT
Characterizing the fast variability in black hole low-mass X-ray binaries (BHXBs) can help us to understand the geometrical and physical nature of the innermost regions of these sources. Particularly, type-B quasi-periodic oscillations (QPOs), observed in BHXBs during the soft-intermediate state (SIMS) of an outburst, are believed to be connected to the ejection of a relativistic jet. The X-ray spectrum of a source in the SIMS is characterized by a dominant soft blackbody-like component – associated with theVaccretion disc – and a hard component – associated with a Comptonizing region or corona. Strong type-B QPOs were observed by NICER and AstroSat in GX 339-4 during its 2021 outburst. We find that the fractional rms spectrum of the QPO remains constant at ∼1 per cent for energies below ∼1.8 keV, and then increases with increasing energy up to ∼17 per cent at 20–30 keV. We also find that the lag spectrum is ‘U-shaped’, decreasing from ∼1.2 rad at 0.7 keV to 0 rad at ∼3.5 keV, and increasing again at higher energies up to ∼0.6 rad at 20–30 keV. Using a recently developed time-dependent Comptonization model, we fit simultaneously the fractional rms and lag spectra of the QPO, and the time-averaged energy spectrum of GX 339-4 to constrain the physical parameters of the region responsible for the variability we observe. We suggest that the radiative properties of the type-B QPOs observed in GX 339-4 can be explained by two physically-connected comptonizing regions that interact with the accretion disc via a feedback loop of X-ray photons.
Balancing the efficiency and stochasticity of star formation with dust extinction in z ≳ 10 galaxies observed by JWST
Authors: Mirocha Jordan , Furlanetto Steven R 
Published: December 2022

ABSTRACT
Early observations with JWST indicate an overabundance of bright galaxies at redshifts z ≳ 10 relative to Hubble-calibrated model predictions. More puzzling still is the apparent lack of evolution in the abundance of such objects between z ∼ 9 and the highest redshifts yet probed, z ∼ 13–17. In this study, we first show that, despite a poor match with JWST luminosity functions (LFs), semi-empirical models calibrated to rest-ultraviolet LFs and colours at 4 ≲ z ≲ 8 are largely consistent with constraints on the properties of individual JWST galaxies, including their stellar masses, ages, and spectral slopes. We then show that order-of-magnitude scatter in the star formation rate of galaxies (at fixed halo mass) can indeed boost the abundance of bright galaxies, provided that star formation is more efficient than expected in low-mass haloes. However, this solution to the abundance problem introduces tension elsewhere: because it relies on the upscattering of low-mass haloes into bright magnitude bins, one expects typical ages, masses, and spectral slopes to be much lower than constraints from galaxies observed thus far. This tension can be alleviated by non-negligible reddening, suggesting that – if the first batch of photometrically selected candidates are confirmed – star formation and dust production could be more efficient than expected in galaxies at z ≳ 10.
The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities
Authors: Jiménez-Panizo Alba , Alegre-Martí Andrea , Tettey Theophilus T , Fettweis Gregory , Abella Montserrat , Antón Rosa , Johnson Thomas A , Kim Sohyoung , Schiltz R Louis , Núñez-Barrios Israel , Font-Díaz Joan , Caelles Carme , Valledor Annabel F , Pérez Paloma , Rojas Ana M , Fernández-Recio Juan , Presman Diego M , Hager Gordon L , Fuentes-Prior Pablo , Estébanez-Perpiñá Eva 
Published: December 2022

Abstract
The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that controls metabolic and homeostatic processes essential for life. Although numerous crystal structures of the GR ligand-binding domain (GR-LBD) have been reported, the functional oligomeric state of the full-length receptor, which is essential for its transcriptional activity, remains disputed. Here we present five new crystal structures of agonist-bound GR-LBD, along with a thorough analysis of previous structural work. We identify four distinct homodimerization interfaces on the GR-LBD surface, which can associate into 20 topologically different homodimers. Biologically relevant homodimers were identified by studying a battery of GR point mutants including crosslinking assays in solution, quantitative fluorescence microscopy in living cells, and transcriptomic analyses. Our results highlight the relevance of non-canonical dimerization modes for GR, especially of contacts made by loop L1–3 residues such as Tyr545. Our work illustrates the unique flexibility of GR’s LBD and suggests different dimeric conformations within cells. In addition, we unveil pathophysiologically relevant quaternary assemblies of the receptor with important implications for glucocorticoid action and drug design.
Effectiveness and Acceptability of Conversational Agents for Smoking Cessation: A Systematic Review and Meta-analysis
Authors: He Linwei , Balaji Divyaa , Wiers Reinout W , Antheunis Marjolijn L , Krahmer Emiel 
Published: December 2022

AbstractIntroductionConversational agents (CAs; computer programs that use artificial intelligence to simulate a conversation with users through natural language) have evolved considerably in recent years to support healthcare by providing autonomous, interactive, and accessible services, making them potentially useful for supporting smoking cessation. We performed a systematic review and meta-analysis to provide an overarching evaluation of their effectiveness and acceptability to inform future development and adoption.Aims and MethodsPsycInfo, Web of Science, ACM Digital Library, IEEE Xplore, Medline, EMBASE, Communication and Mass Media Complete, and CINAHL Complete were searched for studies examining the use of CAs for smoking cessation. Data from eligible studies were extracted and used for random-effects meta-analyses.ResultsThe search yielded 1245 publications with 13 studies eligible for systematic review (total N = 8236) and six studies for random-effects meta-analyses. All studies reported positive effects on cessation-related outcomes. A meta-analysis with randomized controlled trials reporting on abstinence yielded a sample-weighted odds ratio of 1.66 (95% CI = 1.33% to 2.07%, p &lt; .001), favoring CAs over comparison groups. A narrative synthesis of all included studies showed overall high acceptability, while some barriers were identified from user feedback. Overall, included studies were diverse in design with mixed quality, and evidence of publication bias was identified. A lack of theoretical foundations was noted, as well as a clear need for relational communication in future designs.ConclusionsThe effectiveness and acceptability of CAs for smoking cessation are promising. However, standardization of reporting and designing of the agents is warranted for a more comprehensive evaluation.ImplicationsThis is the first systematic review to provide insight into the use of CAs to support smoking cessation. Our findings demonstrated initial promise in the effectiveness and user acceptability of these agents. We also identified a lack of theoretical and methodological limitations to improve future study design and intervention delivery.
High-sensitivity VLBI observations of water masers in the Seyfert galaxy NGC 1068
Authors: Morishima Yuna , Sudou Hiroshi , Yamauchi Aya , Taniguchi Yoshiaki , Nakai Naomasa 
Published: December 2022

AbstractWe present observational results of water vapor maser emission with our high-sensitivity 22 GHz very long baseline interferometry (VLBI) imaging of the Seyfert galaxy NGC 1068. In this galaxy, there are the following four nuclear radio sources; NE, C, S1, and S2. Among them, the S1 component has been identified as the nucleus while the C component has been considered as attributed to the radio jet. In our VLBI observation, we find the following two types of water maser emission at the S1 component. One is a linearly aligned component that is considered as an edge-on disk with an inner radius of 0.62 pc. The dynamical mass enclosed within the inner radius was estimated to be 1.5 × 107 M⊙ by assuming the circular Keplerian motion. Note, however, that the best-fitting rotation curve shows a sub-Keplerian rotation (v ∝ r−0.24±0.10). The other is water maser emission distributed around the rotating disk component up to 1.5 pc from the S1 component, suggesting a bipolar outflow from the S1 component. Further, we detected water maser emission in the C component for the first time with VLBI, and discovered a ring-like distribution of water maser emission. It is known that a molecular cloud is associated with the C component (both HCN and HCO+ emission lines are detected by ALMA). Therefore, the ring-like maser emission can be explained by the jet collision to the molecular cloud. However, if these ring-like water masing clouds constitute a rotating ring around the C component, it is likely that the C component also has a supermassive black hole with a mass of ∼106 M⊙ that could be supplied from a past minor merger of a nucleated satellite galaxy.