bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of COVID-19 pandemic-related concern and health routine changes with functioning among individuals with systemic lupus erythematosus
Authors: Plantinga Laura C , Hoge Courtney , Dunlop-Thomas Charmayne , Pearce Brad D , Lim S Sam , Drenkard Cristina , Bowling C Barrett 
Published: February 2022

ObjectiveTo examine whether pandemic-related issues were associated with physical functioning, community mobility and cognition among individuals with SLE.MethodsParticipants were recruited (6 October 2020–11 November 2021) for this cross-sectional study from a population-based cohort of individuals with validated SLE in metropolitan Atlanta, as part of an ongoing ancillary study. Pandemic-related issues (concern about the pandemic (very vs somewhat/not at all concerned); changes in physical activity and sleep (less vs more/same); difficulty obtaining food and medications and accessing routine care (any vs none)) were self-reported. Self-reported physical functioning and episodic and working memory performance were reported as t-scores (such that a score of 50=population mean and a 10-point difference=1 SD) and community mobility scores ranged from 0 to 120, with higher scores representing better functioning for all domains. Differences in scores were assessed via t-tests and age-adjusted, sex-adjusted and race-adjusted linear regression.ResultsAmong 245 participants (mean age, 46 years; 95% female, 77% black), physical functioning t-scores (mean=44) were consistently lower (by 3–5 points) for those who reported concern about the pandemic, less physical activity and sleep, difficulty obtaining food and medications, and accessing routine care. Similarly, community mobility scores (mean=48) were lower (by 10–20 points) for these individuals. There were no substantial differences in episodic memory and working memory t-scores (mean=50 and 47, respectively) by pandemic-related issues.ConclusionWe found that physical functioning and community mobility, but not cognition, were lower among those who reported more concern about the pandemic or greater disruptions to health routines. Future studies should explore interventions among these vulnerable individuals with SLE, who already disproportionately suffer from functional impairment, to maintain functioning and prevent adverse outcomes during times of crisis.
SIGLEC1 enables straightforward assessment of type I interferon activity in idiopathic inflammatory myopathies
Authors: Graf Manuel , von Stuckrad Sae Lim , Uruha Akinori , Klotsche Jens , Zorn-Pauly Lydia , Unterwalder Nadine , Buttgereit Thomas , Krusche Martin , Meisel Christian , Burmester Gerd R , Hiepe Falk , Biesen Robert , Kallinich Tilmann , Stenzel Werner , Schneider Udo , Rose Thomas 
Published: February 2022

ObjectiveTo evaluate sialic acid binding Ig-like lectin 1 (SIGLEC1) expression on monocytes by flow cytometry as a type I interferon biomarker in idiopathic inflammatory myopathies (IIM).MethodsWe performed a retrospective analysis of adult and paediatric patients with the diagnosis of IIM. SIGLEC1 expression was assessed by flow cytometry and was compared with Physician Global Assessment or Childhood Myositis Assessment Scale disease activity scores. Mann Whitney U test and receiver operating characteristic curves were used for cross-sectional data analysis (n=96), two-level mixed-effects linear regression model for longitudinal analyses (n=26, 110 visits). Response to treatment was analysed in 14 patients within 12 months, using Wilcoxon test. SIGLEC1 was compared with interferon-stimulated gene 15/MxA status by immunohistochemical staining of muscle biopsies (n=17).Results96 patients with adult (a) and juvenile (j) dermatomyositis (DM, n=38), antisynthetase syndrome (AS, n=19), immune-mediated necrotising myopathy (IMNM, n=8), inclusion body myositis (IBM, n=9) and overlap myositis (n=22) were included. SIGLEC1 distinguished significantly between active and inactive disease with an area under the curve of 0.92 (95% CI 0.83 to 1) in DM and correlated with disease activity longitudinally (aDM: standardised beta=0.54, p<0.001; jDM: standardised beta=−0.70, p<0.001). Response to treatment in DM was associated with a decreasing SIGLEC1 (p<0.01, Wilcoxon test). SIGLEC1 was found upregulated in 8 of 19 patients with AS, 2 of 9 patients with IBM but not in IMNM.ConclusionSIGLEC1 is a candidate biomarker to assess type I interferon activity in IIM and proved useful for monitoring disease activity and response to treatment in juvenile and adult DM.
Measuring quality of life of patients with axial spondyloarthritis for economic evaluation
Authors: Hernandez Alava Monica , Wailoo Allan , Chrysanthou Georgios , Barcelos Filipe , van Gaalen Floris A , Santos Helena , Fagerli Karen Minde , Gago Laura , Margarida Cunha Maria , van de Sande Marleen , Couto Maura C , Bernardes Miguel , Ramonda Roberta , Exarchou Sofia , Carvalho Pedro D , van der Heijde Desirée , Machado Pedro M 
Published: February 2022

ObjectivesTo estimate the relationship between EQ5D (three levels, UK version) and the Ankylosing Spondylitis Disease Activity Score (ASDAS) for use in the economic evaluation of health technologies for people with axial spondyloarthritis (axSpA). To compare against the relationship with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI).MethodsAn electronic, prospective, Portuguese, nationwide, rheumatic disease register (Reuma.pt) provided data on 1140 patients (5483 observations) with a confirmed diagnosis of axSpA. We estimated models of EQ5D as a function of ASDAS, alone or in combination with measures of functional impairment, using bespoke mixture models which reflect the complex distributional features of EQ5D. The SPondyloArthritis Caught Early cohort provided data from 344 patients (1405 observations) in four European countries and was used for validation. A previously published model of BASDAI/Bath Ankylosing Spondylitis Functional Index (BASFI) was also used to generate predicted EQ5D scores and model performance compared.ResultsA non-linear relationship exists between EQ5D from ASDAS. The final model included ASDAS, ASDAS squared, age and age squared and demonstrated close fit in both datasets except where data were sparse for patients with very high levels of disease activity (ASDAS >4). This finding held in the validation dataset. Models that included BASFI improved model fit. The ASDAS based models fit the data marginally less well than models using BASDAI.ConclusionsMapping models linking ASDAS to EQ5D allow results from clinical studies to be used in economic evaluation of health technologies with confidence. There is some loss of information compared with BASDAI but this has only a marginal impact.
Impact of synovial biopsy procedures and disease-specific aspects on synovial tissue outcome: a systematic literature review informing the EULAR points to consider for the minimal reporting requirements in synovial tissue research in rheumatology
Authors: Najm Aurélie , Costantino Félicie , Weill Catherine , Filer Andrew , D'Agostino Maria Antonieta 
Published: February 2022

BackgroundThe aim of this work was to summarise the literature evaluating the impact of biopsy procedures, tissue handling, tissue quality and disease-specific aspects including joint biopsied and disease stage, on synovial tissue outcome.MethodsTwo reviewers independently identified eligible studies according to the Patients, Intervention, Comparator and Outcome framework obtained for five research questions formulated during the first EULAR task force meeting to produce points to consider (PtC) for minimal reporting requirements in synovial tissue studies. The databases explored were Medline, Embase, CENTRAL and Cinhal. The risk of bias of each study was evaluated using an adapted version of the Joanna Briggs Institute checklist for analytical cross-sectional studies.ResultsOf the 7654 records yielded, 75 full texts were assessed, leading to the inclusion of 26 manuscripts in the systematic literature review (SLR). Two papers assessed the impact of biopsy procedures on the quality and quantity of tissue retrieved alongside patient tolerability; six papers focused on synovial tissue variability. Four papers studied the impact of sample handling or randomisation and 14 assessed the impact of disease stage and state, namely early or established active rheumatoid arthritis and remission on histopathological and transcriptomic results.ConclusionsThis SLR informs the EULAR PtC for minimal reporting requirements in synovial tissue research in rheumatology. Characteristics related to the study design, population, sample handling, randomisation and analysis can affect the final synovial tissue outcome in the studies reviewed. Thus, accurate reporting of these factors is required in order to ensure the scientific validity of manuscripts describing synovial tissue outcomes.
Volar Wrist Ganglion Originating at the Dorsal Scapholunate Ligament – A Report of Two Patients
Authors: KAEMPF DE OLIVEIRA Ricardo , FARINA BRUNELLI João Pedro , AITA Márcio Aurelio , MANTOVANI RUGGIERO Gustavo 
Published: February 2022

Ganglion cysts are common wrist lesions and, in about 20% of patients, they appear on a volar and radial location. Volar ganglions typically arise from the volar radiocarpal joint in the interval between the radioscaphocapitate (RSC) and the long radiolunate (LRL) ligaments. We report two patients with volar and radial ganglion cysts that originated at the dorsum of the scapholunate (SL) ligament. This may lead to inadequate treatment with a risk of recurrence. Level of Evidence: Level V (Therapeutic)
An Evaluation of Replacing Fish Meal with Fermented Soybean Meal in Diet of Hybrid Snakehead (Channa argus × Channa maculata): Growth, Nutrient Utilization, Serum Biochemical Indices, Intestinal Histology, and Microbial Community
Authors: Duan Zhipeng , Zhang Chunyan , Huang Lingling , Lan Qing , Hu Jie , Li Xiaoqin , Leng Xiangjun 
Published: February 2022

The present study investigated the effect of fish meal (FM) replacement with fermented soybean meal (FSM) on growth performance, nutrient utilization, serum biochemical indices, intestinal histology, and microbial community of hybrid snakehead. Five isonitrogenous diets were formulated with FSM inclusion to decrease dietary FM from 350 g/kg (the control diet) to 300, 250, 200, and 150 g/kg, referring to CON, FM-30, FM-25, FM-20, and FM-15, respectively, and then fed to hybrid snakehead with initial body weight of

6.49
±
0.03

g

for 60 days. The control group showed the best growth with a weight gain rate (WGR) of 417.0% and a feed conversion ratio (FCR) of 0.84, but the WGR in FM-25, FM-20, and FM-15 groups was decreased by 26.25%, 40.60%, and 42.23% and FCR was increased by 0.24, 0.45, and 0.45, respectively, when compared to those in the CON group (

P
<
0.05

). The apparent digestibility coefficients of dry matter and crude protein, the protein efficiency and retention, the serum total cholesterol content, and the intestinal muscle thickness in FM-20 and FM-15 groups and the villus height in all FSM groups were significantly lower than those in the CON group (

P
<
0.05

). Intestinal microbiota analysis indicated that the main microorganisms included Proteobacteria, Firmicutes, and Actinobacteria. At the genus level, Plesiomonas was the dominant genus with the highest relative abundance in the FM-20 group. In summary, in a diet containing 350 g/kg FM, FSM can successfully replace 50 g/kg dietary FM without negative effects on growth performance, nutrient utilization, serum biochemical indices, and intestinal health of hybrid snakehead juvenile.
Race-associated Molecular Changes in Gynecologic Malignancies
Authors: Asare Amma , Yao Hui , Lara Olivia D. , Wang Ying , Zhang Lin , Sood Anil K. 
Published: February 2022

The difference in cancer morbidity and mortality between individuals of different racial groups is complex. Health disparities provide a framework to explore potential connections between poor outcomes and individuals of different racial backgrounds. This study identifies genomic changes in African American patients with gynecologic malignancies, a population with well-established disparities in outcomes. Our data explore whether social health disparities might mediate interactions between the environment and tumor epigenomes and genomes that can be identified. Using The Cancer Genetic Ancestry Atlas, which encodes data from The Cancer Genome Atlas by ancestry and allows for systematic analyses of sequencing data by racial group, we performed large-scale, comparative analyses to identify novel targets with alterations in methylation, transcript, and miRNA expression between tumors from women of European American or African American racial groups across all gynecologic malignancies. We identify novel discrete genomic changes in these complex malignancies and suggest a framework for identifying novel therapeutic targets for future investigation.

Significance:
Common genetic changes in breast, ovarian, cervix, and uterine tumors can be identified in African American patients. Understanding why these changes occur may help improve outcomes for all patients with cancer.
Management of Major Injuries to the Bile Duct at a Hepatobiliary Specialty Referral Center
Authors: Zendel Alex , Kumar Aman , Serrano Pablo , de Oliveira Guilherme C. , Button Julia , Gebre Betelhme , Gerber David A. , Desai Chirag S. 
Published: February 2022

Introduction Aim is to evaluate geographical and demographic factors influencing management of bile duct injuries occurring during cholecystectomy in a tertiary hepato-pancreato-biliary center in Southeast US. Methods All referrals for biliary injuries during cholecystectomy, between Jan 2017 and December 2020 were included. Results 19 patients were identified with a median age of 59 (47-65), average BMI of 30.3 (18-49), and the prevalence of diabetes mellitus, hypertension and cardiovascular disease of 11%, 47% and 16%, respectively. The average transfer distance was 76 miles (8-102) and median transfer time was 3 days (1-12). 16 (84%) had Strasberg E injury, with 4 (21%) having a concomitant vascular injury (3 - right hepatic artery, 1 - right portal vein). Two (10.5%) were managed non-operatively, immediate surgical repair was performed in 2 (10.5%) and 15 (78.9%) patients underwent a delayed repair with a median of 87 days (69-118) from injury to repair. Median operative time was 5 hours (4-7), blood loss was 150 mL (100-200) and hospital stay was 8 days (6-12). Discussion Factors including distance between hospitals, delays in patient transfer due to bed availability and transportation, play a role in the decision-making towards delayed repair. The delayed repair has the benefit of medical optimization of our high-risk patients’ population.
Children Undergoing Laryngeal Surgery for Obstructive Sleep Apnea: NSQIP Analysis of Length of Stay, Readmissions, and Reoperations
Authors: Kuo Cathleen C. , Elrakhawy Mohamed , Carr Michele M. 
Published: February 2022

Objective: No national study to date has specifically evaluated the predictive variables associated with extended hospitalization and other postoperative complications following laryngeal surgery in children with obstructive sleep apnea (OSA). The goals of this study were to identify perioperative risk factors and provide a descriptive analysis of surgical outcomes in these children using the National Surgical Quality Improvement Program–Pediatrics (NSQIP-P) database. Methods: Patients aged 0 to 18 years who underwent laryngeal surgery with a postoperative diagnosis of OSA were queried via the 2014-2018 NSQIP-P database using Current Procedural Terminology code 31541. Variables collected included age, sex, ethnicity, body mass index (BMI), medical comorbidities, American Society of Anesthesiologists (ASA) physical classification, operative time, and concurrent procedures. Endpoints of interest were length of stay, unplanned reoperation, readmission, reintubation, and postoperative complications. Univariate and multivariate linear regression analyses were performed. Results: A total of 181 cases were identified (57.5% male and 42.5% female, mean age 4.36 years, range 14 days-17.7 years). Body mass index ( P = .015, OR = 0.96), structural CNS abnormality ( P = .034, OR = 1.95), preoperative oxygen supplementation ( P = .043, OR = 1.28), operative time ( P = .019, OR = 1.84, 95% CI = 1.28-2.54), and concurrent procedure ( P < .001, OR = 2.21) were all independently associated with LOS. Postoperative complications had no significantly associated variables, with an overall low incidence of readmission (5.0%), reoperation (1.7%), and reintubation (1.1%). Conclusion: In this data set, children with OSA undergoing laryngeal surgery experienced minimal postoperative complications. Recognition of the factors associated with increased LOS could lead to improvement in the quality of care for children with OSA.
Medical Decision Style and COVID-19 Behavior
Authors: Tinghög Gustav , Strand Liam 
Published: February 2022

Given the flood of health-related information stirred up by the coronavirus disease 2019 (COVID-19) pandemic, it is important to understand the factors that influence people to engage in protective public health measures so that medical communication can be tailored to be effective. Following the idea that people have a general inclination toward health care utilization, which is either more passive (i.e., medical minimizer) or more aggressive (i.e., medical maximizer), we assess if this inclination extends to being more or less willing to engage in protective public health behavior. We investigate the effect of individual differences in medical minimizing and medical maximizing orientation on COVID-19–related protective behaviors and attitudes. We used the validated Medical Maximizer-Minimizer Scale (MMS) and surveyed a diverse opt-in sample of the Swedish population ( n = 806). Our results show that the MMS significantly predicts a wide range of self-reported behaviors and attitudes in relation to COVID-19. Participants with a stronger minimization orientation were significantly less likely to practice social distancing, follow hygiene recommendations, and be supportive of strict COVID-19 policies. Participants with a stronger maximization orientation had a larger discrepancy between perceived own risk and others getting infected. Thus, they perceived themselves as being less at risk for getting infected compared to the average person. Our findings imply that the MMS can be effectively used to predict who is more or less reluctant to follow public health recommendations. JEL codes: D70 E71 I12 I18
A challenge in diagnosing rash in HIV-positive MSM patient during overlapping epidemics in Central and Eastern Europe: Case report
Authors: Bieńkowski Carlo , Kowalska Justyna D 
Published: February 2022

In 2018-19, in Poland, there was a significant increase in the incidence of both measles and syphilis. In 2019, a 38-year-old HIV-positive MSM patient was admitted to a Department of Hospital for Infectious Diseases in Warsaw due to a rash on his trunk and palms. The patient had a past medical history notable for several syphilis episodes and hepatitis C twice. The patient was under care of the HIV Outpatient Clinic in the Hospital for Infectious Diseases in Warsaw since 2015, on fully effective antiretroviral therapy. Due to new syphilis onset with high titers and concomitant acute hepatitis C, he was hospitalized and treated with crystalline penicillin in a dose of 4x5 million units intravenously for 2 weeks along with benzathine penicillin 2.4 million units intramuscularly before being discharged. Ten days after being discharged home, the patient presented at the HIV clinic with fever and a non-itchy maculopapular rash that first appeared on the face and then also on the trunk and limbs. In presumptive diagnosis, three main conditions were taken into account: new onset of sexually transmitted disease, delayed allergic reaction to benzathine penicillin, and—in relation to a recent epidemical outbreak—measles. On physical examination, small white spots on the inner lining of the cheek were found (Koplik’s spots). Swabs taken for measles RNA testing confirmed the diagnosis. Regarding the fact that both diseases may occur with a rash, they may pose a diagnostic challenge. Physicians should always include local epidemiological situation, including the possibility of overlapping outbreaks in differential diagnosis of nonspecific symptoms.
Nursing and advocacy in health: An integrative review
Authors: Heck Letícia Olandin , Carrara Bruna Sordi , Mendes Isabel Amélia Costa , Arena Ventura Carla Aparecida 
Published: February 2022

Background The practice of health advocacy in nursing has been defined as a process aimed at promoting the independence and autonomy of users of health services, in addition to providing information on healthcare decision-making and offering support for decisions taken. Ethical considerations Ethics approval was not required to conduct this review. Aim This integrative review aims to synthesize evidence in the literature on health advocacy in professional nursing practice. Methods An integrative review methodology guided by Whittemore and Knalf was used. Studies were identified by conducting searches on PubMed, Scopus, Web of Science, CINAHL, and LILACS databases. Of 2179 records, 34 studies matched the inclusion criteria. Results The main aspects involved in the practice of health advocacy by professional nurses are related to the ethical principles of the nursing profession, such as protecting patients seeking autonomy and care. Furthermore, the practice of health advocacy by nurses requires an empathetic attitude, responsibility, and assertive communication. Conclusion The diverse possibilities for the practice of advocacy synthesized in this study allow nurses to approach and become familiarized with the topic, being able to acquire and complement knowledge that will reflect on their professional practice in different work environments such as the educational field, in hospital practice, or basic health care.
Retinal vascular impairment matched to the pulmonary damage in early post-COVID 19 patients
Authors: Savastano Maria Cristina , Larici Anna Rita , Crincoli Emanuele , De Filippis Alessandro , Cicchetti Giuseppe , Gambini Gloria , Savastano Alfonso , Marano Riccardo , Natale Luigi , Rizzo Stanislao 
Published: February 2022

Background Endothelium damage is a crucial element in the pathogenesis of SARS-Cov-2 infection. Most casualties in critical COVID-19 cases are due to ARDS, diffuse coagulopathy and cytokine storm. ARDS itself is a consequence of pulmonary endothelial cells damage. Damage to retinal capillary microcirculation in post-infective period has been investigated through Optical Coherence Tomography Angiography (OCTA). The aim of the present study is to find a correlation between signs of retinal vascular damage and pulmonary impairment. Methods Patients admitted to hospital and subsequently recovered from COVID-19 infection were summoned 1 month later to undergo coherence tomography (CT) scan and OCTA examination. Results The study population included 87 COVID-19 patients with a mean age of 54.28 ± 14.44 years. Oxygen therapy, non-invasive and invasive mechanical ventilation were necessary in 33, 11 and 4 patients respectively to provide respiratory support during the acute course of the disease. Pulmonary involvement interested 54 patients (62.1%). Peripheral (27.6%) or diffuse (29.9%) involvement and ground glass (GG) opacities (47.1%) represented the prevalent radiological finding. A reduced RCPI FI was independently correlated with the presence of reticulation pattern in CT scan ( p = .019). Also, RNFL and GCC were thinner in patients who displayed reticulation pattern (respectively p = .025 and p = .015). Conclusions A reduction in RPCP-FI and RNFL and GCC thickness were independently correlated to the presence of CT reticulation pattern. This association can reflect cytokine induced remodeling in both organs as a consequence of systemic endothelial damage and inflammation.