bluuebunny/crossref_metadata_2025_split huggingface dataset:
Audiovisual teleconsultation for patients with epilepsy in primary care in rural Germany: a pilot study on feasibility and acceptance
Authors: Feldmeier Gregor , Löffler Christin , Altiner Attila , Wollny Anja , von Podewils Felix , Ritzke Manuela 
Published: September 2022

Abstract
Background
In rural areas, epilepsy patients have limited access to specialist secondary care. Substantial travel and waiting times of several hours are common. Communication between general practitioners (GP) and specialist epileptologists regarding diagnosis and treatment is further complicated by the high workload on both sides and the different prioritisation of treatment goals. This study aims to investigate the feasibility of an interprofessional audiovisual patient-doctor teleconsultation, and its acceptance in clinical practice in patients with epilepsy in a rural region in Germany.

Method
Ten patients participated in telemedicine consultations in their GP practice. The practice was located in a sparsely populated region of Mecklenburg-Western Pomerania, and was equipped with technical equipment specifically procured for the project. An explorative qualitative interview was conducted with all participants. We based this paper on the consolidated criteria for reporting qualitative research (COREQ).

Results
Despite initial uncertainties on the patients’ side regarding the consultation setting, all participants found the teleconsultation helpful. Some patients were initially intimidated and felt slightly overwhelmed by the attention provided and the technology used (multiple HD cameras, large high-resolution screens). However, during the consultation, they felt supported by their GP and were satisfied that their needs were addressed in an appropriate and timely manner. The hardware used was not felt to be a nuisance or to interfere with the conversation between doctor and patient. Patients also appreciated the time saved and the organisational convenience compared to a visit to a university outpatient clinic. Most consultations led to therapeutic consequences. Some patients seemed to benefit particularly, for example those who needed a medication change.

Conclusion
This pilot study provides first evidence that teleconsultations between patients, specialists, and GPs are possible in rural areas. Interprofessional collaboration between GPs and epileptologists can improve the care of patients with epilepsy. Further research should investigate the effectiveness and efficiency of interprofessional telemedicine consultations for epilepsy and other conditions.
Feasibility of a Supervised Virtual Exercise Program for Women on Hormone Therapy for Breast Cancer
Authors: Myers Samantha A. , Weller Sarah , Schwartz Sarah , Van Patten Cheri , LeVasseur Nathalie , Faulkner Guy , Campbell Kristin L. 
Published: September 2022

ABSTRACT

Introduction/Purpose
Adjuvant endocrine therapy significantly improves survival in women with hormone receptor–positive breast cancer and is typically administered for 5 yr or longer. Adverse treatment side effects, including arthralgias, reduce treatment adherence and physical activity levels. Aerobic and resistance exercise is one strategy to decrease treatment side effects and improve treatment adherence. This study aimed to explore the feasibility of a virtually delivered exercise program for women receiving adjuvant endocrine therapy as part of breast cancer treatment.

Methods
This is a single-arm pilot study with recruitment by self-referral or oncologist referral of female breast cancer survivors. To adapt to coronavirus disease 2019 (COVID-19) restrictions, a supervised strength and aerobic group exercise program was delivered virtually twice weekly via Zoom over 6 wk. Feasibility was evaluated based on a priori targets specific to program recruitment (>30% recruitment ratio), transition to virtual delivery (>75%), attendance (>70% virtual session attendance), attrition (<30% dropout), and fidelity of group belongingness (average score ≥15 on belongingness questionnaire) at the end of the program. Physical function (30-s chair stand test), quality of life RAND Short-Form 36-item test, and medication adherence (Voils Domains of Subjective Extent of Nonadherence) were assessed at baseline and 6 wk.

Results
A total of 24 participants completed the program. All feasibility measures were met. Statistically significant changes were found in physical function (P < 0.001), self-reported energy/fatigue (P < 0.001), emotional well-being (P < 0.001), and pain (P = 0.01). There was also a positive trend toward improvement in patient-reported medication adherence (17%).

Conclusion
A 6-wk supervised strength and aerobic group exercise intervention delivered virtually was feasible and improved physical function, energy/fatigue, emotional well-being, and pain. The trend toward improvement in adherence to adjuvant endocrine therapy should be explored further. These findings provide preliminary data to inform a future appropriately powered trial on exercise and physical function using a virtual platform that has the potential for greater reach.
Physiotherapy interventions for head and trunk control in children with developmental disabilities: A scoping review protocol
Authors: Shakya Shristi , Parsekar Shradha S. , Ramachandran Selvam , Madapura S. Shamantha , Balakrishna Shetty Harikishan , Anaby Dana , Gopalakrishna Sivakumar , Venkatesan V. S. , Rao Bhamini Krishna 
Published: September 2022

Background: Head and trunk control is prerequisite skill that maximizes engagement and participation in one’s environment by integrating vision, oromotor skill, arm control and respiration. Various physiotherapy and technology-based interventions have been utilized to facilitate head and trunk control in children with developmental disabilities. This scoping review is planned to map and summarize existing studies from the scientific literature on physiotherapy and technology-based interventions for head and trunk control in children with developmental disabilities. Methods: The scoping review will utilize the Joanna Briggs Institute scoping review methodology. The review will cover studies including children and adolescents aged between two years and 17 years 11 months 29 days, with developmental disabilities where in child finds difficulty aligning head and trunk in sitting position, against gravity, for more than a minute. We will include randomized controlled trial (RCT), non-RCT, quasi-experimental trial, and systematic reviews that have employed physiotherapy and technology-based interventions. Database-specific search strategy will be used to search records in Medline (PubMed and Web of Science), Embase, Scopus, CINAHL, PEDro, and Cochrane Library. Additionally, various grey literatures and clinical-trial registries will be searched. Two reviewers, independently, will screen and extract the data. Tables and visual representations will be utilized to present the extracted data. Registration details: The protocol has been registered in Open Science Framework, DOI: 10.17605/OSF.IO/B3RSU (22nd August 2022)
Challenges in specifying parameter values for COVID-19 simulation models
Authors: Endo Akira , Nishi Akihiro 
Published: September 2022

A recent modelling paper on the coronavirus disease 2019 (COVID-19) epidemic in the US (Bartsch et al.) suggested that maintaining face mask use until a high vaccine coverage (70–90%) is achieved is generally cost-effective or even cost-saving in many of the scenarios considered. Their conclusion was based on the assumed effectiveness of continued face mask use, cited from a study that reported an 18% reduction in the effective reproduction number associated with the introduction of state-level mask mandate policies in the US in the summer of 2020. However, using this value implicitly assumes that the effect of face mask use in 2021 through 2022 is the same as that of summer 2020, when stringent nonpharmaceutical interventions were in place. The effectiveness of universal mask wearing in 2021–2022 is probably more uncertain than considered in Bartsch et al. and rigorous sensitivity analysis on this parameter is warranted.
Health effects of UV nail lamps - is there a risk of cancer?
Authors: Basta-Arciszewska Katarzyna , Arciszewski Kamil , Borowik Joanna , Brodowski Wojciech , Swora Aleksandra , Sygacz Oliwer , Pawłowski Piotr , Żelazny Przemysław , Filipczak Joanna , Dankiewicz Sara , Bróż Sebastian 
Published: September 2022

Introduction:
Every year, more and more people are using manicure and pedicure services performed with UV lamps. As public awareness of the harmfulness of prolonged exposure to UV light increases, there are doubts about the safety of frequent treatments using it.
Aim of the study:
The aim of the study was to find out whether regular use of UV nail lamps is safe and to educate patients about the prevention of potential cancer.
Methods and materials:
A literature review was performed in the PubMed database using the keywords: UV; nail lamp; skin cancer; risk.
Resulsts:
Certain clinical cases indicate that long-term, regular exposure to UVA radiation from nail lamps can increase the risk of squamous cell carcinoma of the skin and actinic keratosis, but other risk factors may overlap. According to a statement by the U.S. Food and Drug Administration (FDA), the use of these devices is safe. Thus, the results of the studies appear to be inconclusive. Both the researchers who prove the safety of lamp use and those who question it unanimously recommend the use of prophylaxis and educating patients about it.
Conclusions:
The use of UV nail lamps is not associated with significant risks. Single clinical cases describing the development of squamous cell carcinoma of the skin and actinic keratosis appear to be anecdotal. As the low probability of cancer formation is still taken into account, it is worth taking the recommended precautions: using creams with a broad-spectrum UV filter 20 minutes before exposure or manicure gloves. Using LED nail lamps instead of classic UV lamps will also be beneficial. The topic is a developing one and will require more research attention.
Endoprosthetic replacement of the proximal tibia for oncological conditions
Authors: Sacchetti Federico , Aston Will , Pollock Rob , Gikas Panos , Cuomo Pierluigi , Gerrand Craig 
Published: September 2022

Aims The proximal tibia (PT) is the anatomical site most frequently affected by primary bone tumours after the distal femur. Reconstruction of the PT remains challenging because of the poor soft-tissue cover and the need to reconstruct the extensor mechanism. Reconstructive techniques include implantation of massive endoprosthesis (megaprosthesis), osteoarticular allografts (OAs), or allograft-prosthesis composites (APCs). Methods This was a retrospective analysis of clinical data relating to patients who underwent proximal tibial arthroplasty in our regional bone tumour centre from 2010 to 2018. Results A total of 76 patients fulfilled the inclusion criteria and were included in the study. Mean age at surgery was 43.2 years (12 to 86 (SD 21)). The mean follow-up period was 60.1 months (5.4 to 353). In total 21 failures were identified, giving an overall failure rate of 27.6%. Prosthesis survival at five years was 75.5%, and at ten years was 59%. At last follow-up, mean knee flexion was 89.8° (SD 36°) with a mean extensor lag of 18.1° (SD 24°). In univariate analysis, factors associated with better survival of the prosthesis were a malignant or metastatic cancer diagnosis (versus benign), with a five- and ten-year survival of 78.9% and 65.7% versus 37.5% (p = 0.045), while in-hospital length of stay longer than nine days was also associated with better prognosis with five- and ten-year survival rates at 84% and 84% versus 60% and 16% (p < 0.001). In multivariate analysis, only in-hospital length of stay was associated with longer survival (hazard ratio (HR) 0.23, 95% confidence interval (CI) 0.08 to 0.66). Conclusion We have shown that proximal tibial arthroplasty with endoprosthesis is a safe and reliable method for reconstruction in patients treated for orthopaedic oncological conditions. Either modular or custom implants in this series performed well. Cite this article: Bone Jt Open 2022;3(9):733–740.
GenOtoScope: Towards automating ACMG classification of variants associated with congenital hearing loss
Authors: Melidis Damianos P. , Landgraf Christian , Schmidt Gunnar , Schöner-Heinisch Anja , von Hardenberg Sandra , Lesinski-Schiedat Anke , Nejdl Wolfgang , Auber Bernd 
Published: September 2022

Since next-generation sequencing (NGS) has become widely available, large gene panels containing up to several hundred genes can be sequenced cost-efficiently. However, the interpretation of the often large numbers of sequence variants detected when using NGS is laborious, prone to errors and is often difficult to compare across laboratories. To overcome this challenge, the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP) have introduced standards and guidelines for the interpretation of sequencing variants. Additionally, disease-specific refinements have been developed that include accurate thresholds for many criteria, enabling highly automated processing. This is of particular interest for common but heterogeneous disorders such as hearing impairment. With more than 200 genes associated with hearing disorders, the manual inspection of possible causative variants is particularly difficult and time-consuming.
To this end, we developed the open-source bioinformatics tool GenOtoScope, which automates the analysis of all ACMG/AMP criteria that can be assessed without further individual patient information or human curator investigation, including the refined loss of function criterion (“PVS1”). Two types of interfaces are provided: (i) a command line application to classify sequence variants in batches for a set of patients and (ii) a user-friendly website to classify single variants.
We compared the performance of our tool with two other variant classification tools using two hearing loss data sets, which were manually annotated either by the ClinGen Hearing Loss Gene Curation Expert Panel or the diagnostics unit of our human genetics department. GenOtoScope achieved the best average accuracy and precision for both data sets. Compared to the second-best tool, GenOtoScope improved the accuracy metric by 25.75% and 4.57% and precision metric by 52.11% and 12.13% on the two data sets, respectively. The web interface is accessible via: http://genotoscope.mh-hannover.de:5000 and the command line interface via: https://github.com/damianosmel/GenOtoScope.
Intimate-partner violence and its association with symptoms of depression, perceived health, and quality of life in the Himalayan Mountain Villages of Gilgit Baltistan
Authors: Nowshad Gul , Jahan Neelum , Shah Nasim Zahid , Ali Nasloon , Ali Tazeen , Alam Sartaj , Khan Ambreen , Mahmood Mohammad Afzal , Saba Malika , Arnone Danilo , Shah Syed M. 
Published: September 2022

Study objectives
We aimed to estimate the prevalence of intimate partner violence (IPV) and associated risk factors in married women in rural villages of Gilgit Baltistan in Pakistan.

Methods
A cross-sectional design to assess the magnitude and factors associated with IPV in a random sample of 789 married women aged 18–49 years. A World Health Organization screening instrument was used to assess the presence of IPV in the previous 12 months. A locally validated instrument was adopted to identify self-reported symptoms of major depression according to the DSM IV. Trained nurses obtained socio-demographic and reproductive history through structured interviews. Bivariate and multivariable logistic regression analyses were used to estimate prevalence and identify significant predictors of IPV.

Results
The mean age of the participants was 38.3 years (SD: ±12.8). The prevalence of IPV in women was 22.8% (95% Confidence Interval: 20.0–25.9), 18.5% in pregnant women (95% CI: 11.7–27.9) and significantly associated with depression in 55.1% of IPV cases. Husband education level (college/higher) (Adjusted Odds Ratio: 0.40; 95%CI: 0.22–0.70) and high household income (AOR: 0.44; 95% CI: 0.29–0.68) were protective against IPV. Increase in age (AOR;1.02; 95% CI: 1.01–1.02) and poor relationship with mother-in-law increased the risk of IPV (AOR = 2.85; 95% CI: 1.90–4.28). IPV was positively associated with symptoms of depression (AOR = 1.97; 95% CI:1.39–2.77), poor perceived quality of life (AOR = 3.54; 95% CI: 1.90–6.58) and poor health (AOR = 2.74; 95% CI: 1.92–3.92).

Conclusion
IPV is substantial public health burden significantly associated with depressive symptoms, poor perceived health and the quality of life.
Donor-derived urologic cancers after renal transplantation: A retrospective non-randomized scientific analysis
Authors: Hellström Vivan , Tufveson Gunnar , Loskog Angelica , Bengtsson Mats , Enblad Gunilla , Lorant Tomas 
Published: September 2022

Background
Malignancies in the urinary tract and the kidney graft are quite common after kidney transplantation. In some selected cases tumours develop from donor-derived tissue.

Objectives
We hypothesised that there is a clinical value to investigate donor/recipient origin in urologic malignancies in renal transplant recipients.

Methods
In this retrospective study, including patients transplanted between the years 1969 and 2014 at Uppsala University Hospital, Sweden, 11 patients with malignancies in urinary tract and 4 patients with malignancies in kidney transplants were investigated. Donor/recipient origin of tumour tissue was analysed by polymerase chain reaction (PCR) of human leucocyte antigen (HLA) genotypes or by fluorescence in situ hybridization (FISH analysis) of sex chromosomes. HLA genotype and sex chromosomes of the tumour were compared to the known HLA genotype and sex chromosomes of recipient and donor.

Results
Three of ten cancers in the urinary tract and three of four cancers in the kidney transplants were donor-derived.

Conclusions
We suggest that urologic malignancies in renal transplant recipients can be investigated for transplant origin. In addition to conventional therapy the allograft immune response against these tumours can be valuable to treat donor-derived cancers.
Predictive factors for alpha blocker use after transurethral prostatectomy: Can preoperative urodynamic outcome predict alpha blocker medication after surgery?
Authors: Kim Sung Jin , Park Sung Gon , Pak Sahyun , Lee Young Goo , Cho Sung Tae , Kwon Ohseong 
Published: September 2022

Objective
To analyze the diagnostic value of conducting urodynamic study (UDS) and show predictors for alpha blocker use 12 months after transurethral prostatectomy.

Materials and methods
Our study includes 406 participants that had a transurethral prostatectomy at our hospital between 2010 and 2019. All participants took alpha blockers for more than a month. We collected the participants’ preoperative international prostatic symptom score (IPSS), uroflowmetry, transrectal ultrasound, and serum prostatic antigen (PSA) level. A total of 254 patients conducted UDS. After surgery, participants visited our hospital at 1,3,6, and 12 months.

Results
133 patients (32.6%) took alpha blockers continuously for 12 months after surgery. They reported poor preoperative IPSS scores and uroflowmetry outcomes. They also had high postoperative PVR (40.68±24.56 vs 29.34±25.11, p<0.001) and total IPSS score (10.35±7.96 vs 8.43±6.74, p = 0.018) compared to the group which discontinued alpha blockers. A multivariate analysis (Table 2) found that conducting preoperative UDS (Odds ratio (OR) 6.067, p<0.001) Age>75 (OR 2.463, p<0.001), a history of taking 5-alpha reductase inhibitors (5-ARI) before surgery (OR 2.186 [95% CI 1.334–3.583], p = 0.002), IPSS item straining (OR 1.224, p = 0.003), duration of taking alpha blockers [OR 1.009, p = 0.020), and Qmax (OR 0.926, p = 0.018), PVR (OR 1.002, p = 0.022) were confirmed as a strong predictors of persistent alpha blocker use.

Conclusion
Conducting preoperative UDS, Age>75, history of taking 5-ARI before surgery, IPSS item straining, duration of alpha blocker medication, Qmax, and PVR are possible determinant factors of alpha blocker use after surgery. By comparing UDS outcomes, detrusor underactivity can be a strong predictor of persisting alpha blocker therapy 12 months after surgery.
Effects of neuromuscular gait modification strategies on indicators of knee joint load in people with medial knee osteoarthritis: A systematic review and meta-analysis
Authors: Silva M. Denika C. , Perriman Diana M. , Fearon Angela M. , Tait Daniel , Spencer Trevor J. , Walton-Sonda Dianne , Simic Milena , Hinman Rana S. , Bennell Kim L. , Scarvell Jennie M. 
Published: September 2022

ObjectivesThis systematic review aimed to determine the effects of neuromuscular gait modification strategies on indicators of medial knee joint load in people with medial knee osteoarthritis.MethodsDatabases (Embase, MEDLINE, Cochrane Central, CINAHL and PubMed) were searched for studies of gait interventions aimed at reducing medial knee joint load indicators for adults with medial knee osteoarthritis. Studies evaluating gait aids or orthoses were excluded. Hedges’ g effect sizes (ES) before and after gait retraining were estimated for inclusion in quality-adjusted meta-analysis models. Certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.ResultsSeventeen studies (k = 17; n = 362) included two randomised placebo-controlled trials (RCT), four randomised cross-over trials, two case studies and nine cohort studies. The studies consisted of gait strategies of ipsilateral trunk lean (k = 4, n = 73), toe-out (k = 6, n = 104), toe-in (k = 5, n = 89), medial knee thrust (k = 3, n = 61), medial weight transfer at the foot (k = 1, n = 10), wider steps (k = 1, n = 15) and external knee adduction moment (KAM) biofeedback (k = 3, n = 84). Meta-analyses found that ipsilateral trunk lean reduced early stance peak KAM (KAM1, ES and 95%CI: -0.67, -1.01 to -0.33) with a dose-response effect and reduced KAM impulse (-0.37, -0.70 to -0.04) immediately after single-session training. Toe-out had no effect on KAM1 but reduced late stance peak KAM (KAM2; -0.42, -0.73 to -0.11) immediately post-training for single-session, 10 or 16-week interventions. Toe-in reduced KAM1 (-0.51, -0.81 to -0.20) and increased KAM2 (0.44, 0.04 to 0.85) immediately post-training for single-session to 6-week interventions. Visual, verbal and haptic feedback was used to train gait strategies. Certainty of evidence was very-low to low according to the GRADE approach.ConclusionVery-low to low certainty of evidence suggests that there is a potential that ipsilateral trunk lean, toe-out, and toe-in to be clinically helpful to reduce indicators of medial knee joint load. There is yet little evidence for interventions over several weeks.
Learning with Differing-Ability Peers: Evidence from a Natural Experiment in South Korea
Authors: Chin Seungwoo , Kwon Eunjee 
Published: September 2022

Abstract
Whether to group students based on their prior academic achievements has been at the center of policy and research debate. This article explores a quasi-experimental setting in South Korea where the “Equalization Policy” replaced ability-tracking in high school students’ allocation. The policy abolished high school entrance exams and began assigning students to high schools without considering students’ prior academic performance, which exposed students to an ability-mixing learning environment. Using a difference-in-difference approach, we show that ability-mixing considerably reduces the number of low-performers in a national college entrance test. At the same time, high-performers are hardly affected by the policy changes. We document that the behavioral changes of low-performing students may drive the main results. In contrast, we find no evidence that grouping mechanisms affect teacher-pupil interaction and teacher quality.