bluuebunny/crossref_metadata_2025_split huggingface dataset:
Earthquake history of the Milas Fault: An active dextral fault in an extensional province (SW Anatolia, Turkey)
Authors: KIRKAN Erdem , Akyüz H. Serdar , Basmenji Mehran , Dikbaş Aynur , Zabcı Cengiz , Yazıcı Müge , Erturaç M. Korhan 
Published: March 2022

Abstract
The Milas Fault (MF) is a poorly known active fault located between the Büyük Menderes Graben to the north and the Gökova Graben to the south within the Anatolia-Aegean Region, SW Turkey. This dextral strike-slip fault has a length of 55 km between the Bafa Lake in the northwest and Çamlıca village in the southeast with a general strike of N60°W as its surface geometry displays two separate segments. We mapped the geomorphological and geological features of the MF by using Google Earth© images, Digital Elevation Models (DEMs) and field observations. The surface traces and kinematic characteristics of the MF are defined by rarely seen carbonate rocks, morphological lineaments and offsets streams, which all suggests a dominantly horizontal deformation for this peculiar tectonic structure. Moreover, we excavated three paleoseismological trenches in order to expose the signature of paleoearthquakes of the MF and to evaluate its seismic hazard potential. Evidences of three paleoearthquake events were revealed in trenches depending on the stratigraphical and structural relations of the exposed strata of latest Quaternary period. These earthquakes are dated as 1702±260 BC-2963±67 BC, 7152±600 BC-13502±3359 BC, and before 13502±3359 BC by means of combined OSL and 14C dating results from youngest to oldest, respectively. These events are supposed to be around or larger than M 7.0 earthquakes. Even there is no constrained dates to propose recurrence interval, combined data from field observations, morphology, seismic records and paleoseismology indicate that the Milas Fault is an active structure and have a potential to produce a similar magnitude earthquake in the future.
Increased genetic variation of A(H3N2) virus from influenza surveillance at the end of the 2016/17 season for Shanghai port
Authors: Tian zhengan , Zhang zilong , Li shenwei , Zhu xiaolin , Hou jian , Zhang hong , Zhao baihui 
Published: March 2022

Abstract
Influenza A(H3N2) virus exhibited complex seasonal patterns to evade pre-existing antibodies, resulting in changes in the antigenicity of the viron surface protein hemagglutinin. To monitor the current circulating influenza viruses as well as to assess the capacity of health emergencies in Shanghai port, we collected respiratory specimens of passengers from different countries and regions including some of Europe with influenza-like illness in Shanghai port during 2016/17 and examined to amino acid substitutions and calculated the perfect-match vaccine efficacy using the p epitope model. Phylogenetic analysis of HA gene revealed that Influenza A(H3N2) viruses belonging to eight clades were detected, and three amino acid substitutions in subclade 3C.2a.4 were also added. Besides, there were two epidemic influenza virus strains circulating in the 2016/17 winter season and 2016 summer season. The results of lower predicted vaccine effectiveness in summer (0.1864) suggest that A(H3N2) strains circulating in 2016 summer was not a good match for the A/Hong Kong/4801/2014 vaccine strain. So, Shanghai port owns the advantage of grasping the risk of international spread of influenza in the first time, and curbing the entry of A(H3N2) from abroad at the earliest stage of the current influenza pandemic.
Clinical N3 is an independent risk factor of recurrence for breast cancer patients achieving pathological complete response and near-pathological complete response after neoadjuvant chemotherapy
Authors: Qian Xiaoyan , Zhang Pin , Xiu Meng , Li Qing , Wang Jiayu , Fan Ying , Luo Yang , Cai Ruigang , Li Qiao , Chen Shanshan , Yuan Peng , Ma Fei , Xu Binghe 
Published: March 2022

Abstract
Background: Although achieving pathological complete response (pCR) and near-pathological complete response (near-pCR) after neoadjuvant chemotherapy (NAC) in breast cancer predicts a better outcome, some patients still experience recurrence. The aim of our study was to analyse the predictive factors of recurrence in the pCR and near-pCR population.Methods: We reviewed 1209 breast cancer patients treated with NAC. A total of 292 patients achieving pCR and near-pCR between January 2010 and April 2021 in the Cancer Hospital, Chinese Academy of Medical Sciences (CHCAMS) were included in our analysis. pCR was defined as ypT0N0/ypTisN0. Near-pCR was defined as ypT1mi/1a/1bN0 or ypT0/isN1mi. The Kaplan-Meier method with the log rank test was used to estimate recurrence analysis.Results: Of the 292 patients,173 were pCR and 119 were near-pCR. The median age was 46 years (range 23-75 years). The predominant tumor subtype was human epidermal growth factor receptor type 2 (HER2) positive (49.0%) and triple-negative breast cancer (TNBC) (30.8%). The median duration of follow-up was 53 months (range 9-138 months). A total of 16 (8.9%) patients developed recurrence, with 9 (5.2%) in the pCR group and 16 (13.4%) in the near-pCR group. The vast majority of recurrence occurred within 36 months from onset of NAC. The 5-year recurrence-free survival (RFS) rate of patients achieving pCR was significantly higher than that of patients achieving near-pCR (94.6% vs.85.6%, P=0.008). Clinical N3 (cN3) before NAC was an independent factor of higher risk for recurrence in patients who achieved pCR (P=0.003) and near-pCR (P=0.036). Tumor size before NAC, subtype of breast cancer and chemotherapy regimens showed no significant association with RFS both for patients who achieved pCR and near-pCR (P ≥0.05). Conclusions: cN3 before NAC was an independent factor of higher risk for recurrence in patients who achieved pCR and near-pCR. It is worthwhile to monitor closely for patients with cN3, especially in the first 3 years.
Forecast of supply and demand of elderly care institutions in Guangzhou from 2021 to 2030 -- Based on the ARIMA Model
Authors: Shi Yongqiang , Fan Fangfang , Zhang Zhiyong 
Published: March 2022

Abstract
Background: With the continuous growth of the elderly population, the pension burden in Guangzhou has increased in recent years, and the aging problem cannot be ignored. This study predicts the relationship between the number of elderly people over 60 years old in Guangzhou and the supply and demand of beds and nursing workers in elderly care institutions in the next ten years and provides a reference for decision-makers to regulate the supply of elderly care resources and formulate policies.Method: Based on the data of the elderly population in Guangzhou from 1990 to 2014, this paper establishes an ARIMA prediction model, uses the data from 2015 to 2020 to verify the validity of the model, and further predicts the number of elderly people, the demand for elderly care facilities and nursing workers from 2021 to 2030 based on specific calculation formulas. Result: In the future, Guangzhou's aging degree will continue to deepen. It is estimated that by 2030, Guangzhou's elderly population will be over 2.9 million. The increase in the number of elderly people puts forward higher requirements for the facilities and human resource supply of elderly care institutions. The prediction results of this study show that the demand for elderly care beds and nursing workers in Guangzhou will exceed 130,000 and 30,000 respectively by 2030.Conclusion: The difficulties in the construction of institutional facilities and the loss of human resources coexist. In the future, the gap between the supply and demand of elderly care facilities and nursing workers will be further expanded. Guangzhou urgently needs to find more effective ways to deal with the increasingly serious aging problem.
Versatile effect of cytokinin on detached senescing leaves of Arabidopsis in the light
Authors: Danilova Maria N. , Kudryakova Natalia V. , Doroshenko Anastasia S. , Daminova Amina G. , Oelmüller Ralf , Kusnetsov Victor V. 
Published: March 2022

Abstract
The dark-detached leaves are widely used as a model to investigate senescence-delaying mechanisms of cytokinin (СК). The role of CK during senescence of detached Arabidopsis leaves in the light is less examined, although they provide unique opportunities for the study of the interaction of CK and the photosynthetic apparatus. Within the first four days of incubation of the leaves on water photosynthesis activity, chloroplast gene expression and chlorophyll content declined in all genotypes with a functioning CK receptor AHK3, while anthocyanin level and expression of its regulatory and biosynthesis genes increased. Application of exogenous CK visibly retarded the senescence symptoms but decreased photosystem II function, anthocyanin accumulation and promoted ROS production. The hormone stimulated starch accumulation in the chloroplasts and altered the expression of the gene for the extracellular cell wall invertase CWINV1. Although the AHK3 receptor played the most important role in the CK action, we also observed specific effects in loss-of function mutants for phosphortransmitters and type B response regulators. The results suggest that CK action in detached Arabidopsis leaves in the light is superimposed on modified carbon fluxes and starch turnover which results in an intricate combination of stress-related and senescence inhibiting effects.
Changes in the anxiolytic and analgesic effects of virtual reality presentations with different content during impacted mandibular third molar extraction.
Authors: Yamashita Yoshio , Aijima Reona , Danjo Atsushi 
Published: March 2022

Abstract
In many cases, surgical procedures are conducted under local anesthesia despite many patients feeling anxious or afraid of treatment. We have recently reported our use of virtual reality (VR) to alleviate the fear and anxiety experienced during oral surgical procedures conducted under local anesthesia. However, the effectiveness of VR in alleviating anxiety varies greatly between individuals, and it has been suggested that these differences in efficacy may depend on the viewer’s level of concentration. We therefore investigated whether the content of the VR presentation made any difference to its effect in alleviating anxiety, and whether it had any analgesic effect. The study subjects were 172 patients who required impacted mandibular third molar extraction under local anesthesia in our department. They experienced one of two different types of VR presentation and were asked to complete a questionnaire about any changes in their anxiety or fear during the procedure, including a visual analog scale (VAS) score. As an objective evaluation, changes in pain threshold during the VR presentation were investigated using PainVision®. Patients who did not experience a VR presentation (n = 48) reported intensified anxiety during the procedure, with an increased VAS score compared with that preoperatively. The VAS scores for patients who experienced a VR presentation, however, decreased significantly. For those patients who experienced a presentation showing a natural landscape (n = 51), the change in VAS score was −13.3 ± 28.7 mm, whereas for those who experienced a presentation showing a video game (n = 73) the change was −22.2 ± 32.1 mm, an even greater reduction. In a pain questionnaire completed by individuals who had experienced the video game presentations, approximately 70% reported that their pain had diminished. An objective evaluation of pain threshold using PainVision® also showed that the pain threshold of individuals increased by around 3% while experiencing the natural landscape VR presentation, but that while experiencing the video game presentation, it increased significantly by around 15% compared with baseline. These results show that the content of the presentation affected not only the rate of decrease in anxiety and fear, but also the pain threshold. This indicated that experiencing a presentation of a video game or another setting in which thought is required may not only alleviate anxiety during surgical procedures, but also diminish pain.
Influence factors and prediction model of enstrophy dissipation from the tip leakage vortex in a multiphase pump
Authors: Shu Zekui , Shi Guangtai , Yao Xin , Sun Guodong , Tao Sijia 
Published: April 2022

Abstract
In a multiphase pump, tip clearance is the required distance between the blade tip and the pump body wall of the impeller, and can regulate tip leakage vortex (TLV), causing unstable flow and energy dissipation. However, there are few studies on the energy dissipation caused by the TLV. In the present work, the enstrophy dissipation theory is innovatively applied to quantitatively study the energy dissipation of the TLV. The flow rate ( Q) , tip clearance ( Rtc) , and inlet gas void fraction ( IGVF ) play a crucial role in affecting the enstrophy dissipation of the TLV. The results suggest that increasing Q , Rtc , and IGVF significantly exacerbate the TLV pattern and raise the TLV scale, which gradually raises volume enstrophy dissipation and decreases wall enstrophy dissipation. The maximum pressure load in the impeller occurs at the 0.5 chord, where a strong TLV is generated, leading to significant enstrophy dissipation. As the flow rate increases, the separation angle between the primary TLV (PTLV) trajectory and the blade gradually decreases, and widely dispersing the enstrophy dissipation near the shroud. However, as the tip clearance increases, the tipseparated vortex (TSV) scale increases and extends to the suction surface, raising the velocity gradient. Besides, as the IGVF increases, the secondary TLV (STLV) develops from a continuous sheet vortex to a scattered strip vortex, increasing the pressure fluctuation intensity. Considering the flow rate, tip clearance, and IGVF as independent variables, simple and multiple nonlinear regression models for the enstrophy dissipation are established.
Modified laparoscopic uterine-sparing surgery combined with gonadotropin-releasing hormone agonist therapy for focal uterine adenomyosis
Authors: Wei Wei-wei , zhang shoufeng , Shi Ru-xia , Zheng Hong , Chen Jiming 
Published: March 2022

Abstract
Objectives
To evaluate the outcomes of women with uterine adenomyoma treated with combined modified laparoscopic adenomyomectomy and gonadotropin-releasing hormone (GnRH) agonists.
Methods
Between 2012 and 2016, 141 women with adenomyoma were admitted to The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University in a retrospective study. All 141 patients were treated with laparoscopic adenomyomectomy combined with GnRH agonists. We used a modified laparoscopic adenomyomectomy technique that involved the insertion of two fingers into the vagina to elevate the uterus, while one finger of the other hand was inserted into the abdomen through a suprapubic 15-mm trocar port for systematic palpation of the uterus. The integrity of the endometrium was preserved for 21 patients who had fertility requirements; for the remaining 120 patients, who did not have fertility requirements, the adenomyosis tissue and the endometrium under the adenomyosis tissue were both resected. We assessed the degree of postoperative clinical improvement, pregnancy outcomes, and possible recurrences. All patients were followed up for at least 24 months.
Results
Combined surgical-medical treatment significantly improved the serum cancer antigen 125 level, hemoglobin level, dysmenorrhea (as indicated by visual analogue scale scores), and menorrhagia (p < 0.05 for all). Of the 23 patients not using contraceptives, 12 (52%) had 14 clinical pregnancies during a 48-month follow-up period. Among the women with fertility requirements, 38.9% of patients had a clinical pregnancy during 48 months of postoperative follow-up. Of the 21 patients with fertility requirements, 4 (19.0%) patients relapsed, and of the 120 patients without fertility requirements, 3 (2.5%) patients relapsed (identified through ultrasound examination).
Conclusion
Laparoscopic adenomyomectomy combined with GnRH agonists can be used to effectively treat adenomyoma. In patients with no fertility requirements, complete resection of the adenomyosis tissue can significantly decrease the relapse risk.
Accreditation as a driver of interprofessional education: The Canadian experience
Authors: Azzam Mohammad B , Girard Marie-Andrée , Andrews Cynthia Lindsay , Bilinski Hope , Connelly Denise , Gilbert John H V , Newton Christie , Grymonpre Ruby E 
Published: March 2022

Abstract
Background: The purpose of this study was to (1) explore evidence provided by Canadian health and social care (HASC) academic programs in meeting their profession-specific interprofessional education (IPE)-relevant accreditation standards; (2) share successes, exemplars, and challenges experienced by HASC academic programs in meeting their IPE-relevant accreditation standards; and (3) articulate the impacts of IPE-relevant accreditation standards on enabling interprofessional learning to the global HASC academic community. Methods: Profession-specific (bilingual, if requested) surveys were developed and emailed to the Deans/Academic Program Directors of eligible academic programs with a request to forward to the individual who oversees IPE accreditation. Responses were collated collectively and by profession. Open-ended responses associated with our first objective were deductively categorized to align with the five Accreditation of Interprofessional Health Education (AIPHE) standards domains. Responses to our additional questions associated with our second and third objectives were inductively categorized into themes. Results/Discussion: Of the 270 HASC academic programs surveyed, 30% (n = 24) partially or completely responded to our questions. Of the 106 IPE-relevant standards where evidence was provided, 62% (n = 66) focused on the Educational Program, 88% of which (n = 58) were either met or partially met, and 47% (n = 31) of which focused on practice-based IPE. Respondents cited various exemplars and challenges in meeting IPE-relevant standards. Conclusions: The overall sentiment was that IPE accreditation was a significant driver of the IPE curriculum and its continuous improvement. The array of exemplars described in this paper may be of relevance in advancing IPE implementation and accreditation across Canada and perhaps, more importantly, in countries where these processes are yet emerging.
Microsurgical treatment of lumbar paravertebral tumors via lateral retroperitoneal approach
Authors: Zhang Lei , Chen Shichao , Wang Kai , Wu Hao 
Published: March 2022

Abstract
Objective
To investigate the surgical techniques and post-operative therapeutic effectiveness of microsurgical treatment of lumbar paravertebral tumors via lateral retroperitoneal approach.
Methods
The clinical data of 6 cases with lumbar paravertebral tumors that went through surgical treatment via lateral retroperitoneal approach in the Neurospine Center of Xuanwu Hospital, Capital Medical University were retrospectively analyzed. The average operation time, volume of blood loss, incision length, length of hospitalization, and the resection rate of paravertebral tumors were collected, score of The Ability to Perform Activities of Daily Living (ADL) and incidents of postoperative complications were recorded.
Results
The operation time ranged from 56 to 181 minutes, with an average of (94.8 ± 48.3) minutes. The volume of blood loss was between 5-100ml, with an average of (31.7 ± 37.5) ml. The length of the surgical incision was 6-7cm, with an average of (6.7 ± 0.5) cm. The hospitalization length was between 5–11 days, with an average of (8.7 ± 2.6) days. The resection rate of paravertebral tumors was 100%. Postoperative pathological diagnosis result revealed 4 cases of schwannoma, 1 case of ganglioneuroma, 1 case of malignant small round cell tumor. During the 3-month follow-up, there was no recurrence of tumors, no abdominal cavity infection and no incisional infection, no incisional hernia, no death cases, and there was no significant decrease of the ADL score compared with that score before the operation.
Conclusion
The surgical treatment of lumbar paravertebral tumors via the lateral retroperitoneal approach has the advantages of short operation time, minimally invasive procedures, quick postoperative recovery, and few complications.
Acceptability of Australian prehospital care quality indicators: an explanatory sequential mixed methods study
Authors: Pap Robin , Stephenson Matthew , Simpson Paul , Lockwood Craig 
Published: March 2022

Abstract
Background: Systematically developed quality indicators (QIs) facilitate the measuring and monitoring of quality of care and ultimately meaningful quality improvement. The aim of this study was to evaluate the acceptability of a predetermined suite of 84 scientifically valid prehospital care QIs from the provider perspective. Methods: An explanatory sequential mixed methods study design was used. Quantitative data were obtained from 36 participants of an online survey in which they rated the acceptability of the QIs using a 5-point Likert-type numerical rating scale. Qualitative data were gathered by conducting semi-structured interviews with a purposive sample of nine survey participants. The successional collection of quantitative and qualitative data facilitated integrated ﻿interpretations and conclusions about the acceptability of the QIs.Results: Generally, the acceptability of all QIs in the suite was rated highly. Data suggested a positive association between acceptability and other key characteristics of QIs. QIs which were seen to be clear, supported by scientific evidence, practical, and meaningful tended to be more acceptable than those which were not. The benefits of outcome type QIs was recognised but participants raised concerns about their sensitivity in the measurement of prehospital quality of care. To be acceptable, QIs which included time intervals needed to be specific about time-critical interventions. Further, the high acceptability of the QIs was explained by a connection to participants’ professional values and qualities. Assessing the QIs’ acceptability from a healthcare provider perspective meant that QIs on patient satisfaction frequently received lower ratings.Conclusion: The findings of this study provide insight into the acceptability to prehospital care providers of a proposed suite of QIs. Future research should evaluate the feasibility and reliability of the QIs. There is also a need to investigate how acceptable the proposed QIs are to patients and communities.