bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing the distribution of the critically endangered estuarine pipefish (Syngnathus watermeyeri) across its range using environmental DNA
Authors: Nester Georgia M. , Heydenrych Matthew J. , Berry Tina E. , Richards Zoe , Wasserman Johan , White Nicole E. , De Brauwer Maarten , Bunce Mike , Takahashi Miwa , Claassens Louw 
Published: October 2022

AbstractThe effective management of rare and threatened species, especially in areas where population sizes have diminished, relies on knowledge of their population size, threats, and distribution. Robust mapping of distribution presents a particular challenge in aquatic environments for cryptic species, especially those with low abundance. Environmental DNA (eDNA) approaches can offer improved detection rates of many rare and threatened species when compared with traditional sampling approaches. In this study, we developed and optimized a targeted eDNA assay for the critically endangered estuarine pipefish (Syngnathus watermeyeri). eDNA sampling and seine netting were undertaken at 39 sites across the historical range of S. watermeyeri in the Eastern Cape of South Africa in 2019. At each site, five water samples were collected for eDNA analysis (n = 195) along with three seine netting hauls (n = 117). Habitat and environmental data were collected at each location to explore what physical and biotic parameters might correlate with pipefish presence/absence. We successfully detected S. watermeyeri in two estuaries (Kariega and Bushmans) using both survey methods. Importantly, the positive detection rate of eDNA (66.7%) was four times that of seine netting (16.7%), highlighting the value of eDNA as a monitoring tool for rare and cryptic species. Null detections in the Kasouga, East Kleinemonde, and West Kleinemonde estuaries add to the growing body of evidence that the estuarine pipefish has been extirpated from these locations and is now only found in two estuarine systems. The occurrence of S. watermeyeri was found to be highly dependent on the cover of submerged macrophytes such as Zostera capensis (eelgrass). By providing a more complete picture of the conservation status of this critically endangered species, this work facilitates the development of a long‐term monitoring program and the identification of priority conservation areas.
Baroreflex activation therapy in advanced heart failure therapy: insights from a real‐world scenario
Authors: Guckel Denise , Eitz Thomas , El Hamriti Mustapha , Braun Martin , Khalaph Moneeb , Imnadze Guram , Fink Thomas , Sciacca Vanessa , Sohns Christian , Sommer Philipp , Nölker Georg 
Published: October 2022

AbstractAimsBaroreflex activation therapy (BAT) is an innovative treatment option for advanced heart failure (HFrEF). We analysed patients' BAT acceptance and the outcome of BAT patients compared with HFrEF patients solely treated with a guideline‐directed medical therapy (GDMT) and studied effects of sacubitril/valsartan (ARNI).MethodsIn this prospective study, 40 HFrEF patients (71 ± 3 years, 20% female) answered a questionnaire on the acceptance of BAT. Follow‐up visits were performed after 3, 6, and 12 months. Primary efficacy endpoints included an improvement in QoL, NYHA class, LVEF, HF hospitalization, NT‐proBNP levels, and 6MHWD.ResultsTwenty‐nine patients (73%) showed interest in BAT. Ten patients (25%) opted for implantation. BAT and BAT + ARNI patients developed an increase in LVEF (BAT +10%, P‐value (P) = 0.005*; BAT + ARNI +9%, P = 0.049*), an improved NYHA class (BAT −88%, P = 0.014*, BAT + ARNI −90%, P = 0.037*), QoL (BAT +21%, P = 0.020*, BAT + ARNI +22%, P = 0.012*), and reduced NT‐proBNP levels (BAT −24%, P = 0.297, BAT + ARNI −37%, P = 0.297). BAT HF hospitalization rates were lower (50%) compared with control group patients (83%) (P = 0.020*).ConclusionsAlthough BAT has generated considerable interest, acceptance appears to be ambivalent. BAT improves outcome with regard to LVEF, NYHA class, QoL, NT‐proBNP levels, and HF hospitalization rates. BAT + ARNI resulted in more pronounced effects than ARNI alone.
A contingency approach to HRM and firm innovation: The role of national cultures
Authors: Yao Jingjing , Marescaux Elise , Ma Li , Storme Martin 
Published: October 2022

AbstractCompanies adopt various HRM practices to enhance employees' abilities, motivations, and opportunities to foster innovation. Are these practices universally effective or culturally contingent? In this study, we draw on the Ability‐Motivation‐Opportunity (AMO) model and examine the effectiveness of three representative practices using a dataset of 304 companies from 13 countries or regions. We find that HRM practices need to fit in a supplementary/complementary way with national cultures to facilitate firm innovation: 1. cross‐functional training (i.e., an ability‐enhancing practice) is more effective in collectivistic rather than individualistic cultures (supplementary fit); 2. financial rewards for innovation (i.e., a motivation‐enhancing practice) are more effective in masculine rather than feminine cultures (supplementary fit); and 3. employee participation (i.e., an opportunity‐enhancing practice) is more effective in high rather than low power distance cultures (complementary fit). By building on the notion of supplementary/complementary fit, these findings extend our knowledge of the AMO model in the context of HRM and innovation management with a cultural contingency perspective.
Assessment of vitamin D levels and adipokines mediated obesity among psychiatric patients on treatment and treatment naïve: A comparative cross‐sectional study
Authors: Fondjo Linda A. , Osei Olivia , Owiredu William K. B. A. , Obirikorang Christian , Senu Ebenezer , Owusu‐Antwi Ruth , Brefo Eugene F. J. 
Published: October 2022

AbstractBackground and aimsAntipsychotic treatment may contribute to low vitamin D levels and have impact on direct anti‐inflammatory activity such as adiponectin activity and indirect proinflammatory activity such as leptin and resistin activity. However, vitamin D levels and adipokines mediated effect on weight gain and increased adiposity are not well evaluated. This study, therefore, assessed vitamin D and adipokines‐mediated obesity among Ghanaian psychiatric patients.MethodsThis comparative cross‐sectional study was conducted at psychiatric unit of Komfo Anokye Teaching Hospital, Kumasi, Ghana. Anthropometric measurements, sociodemographic and previous medical history were taken from 300 antipsychotics treatment naïve and active patients. Obesity was classified using World Health Organization (WHO) body mass index (BMI)‐specific cut‐offs. Blood samples were collected for serum vitamin D and adipokines (adiponectin, leptin, and resistin) analysis using enzyme‐linked immunosorbent assay. Statistical analyses were done using SPSS version 26.0 and GraphPad Prism version 8.0.ResultsWe observed higher prevalence of obesity among treatment active psychiatric patients (40.7%) compared to treatment naïve group (16.8%). Vitamin D insufficiency and deficiency prevalence were significantly higher among the treatment active group (25.3%; 39.5%; p < 0.001) and associated with increased odds of obesity (91.8%; cOR = 91.84, 95% confidence interval [CI]: 24.94–338.13). Moreover, adiponectin (84.2%: cOR = 14.15, 95% CI: 5.52–36.27), leptin (55.6% cOR = 2.20, 95% CI: 1.04–4.67), and resistin (79.4%: cOR = −8.34, 95% CI: 3.39–20.55) were significantly associated with increased odds of obesity among treatment active psychiatric. Furthermore, treatment active psychiatric patients exhibited inverse correlation for adiponectin and leptin with BMI (r = −0.62; −0.24), and WHtR (r = −0.53; −0.24); however, a moderate positive correlation for resistin with BMI (r = 0.80), HC (r = 0.67), and WHtR (r = 0.65).ConclusionObesity is more prevalent in psychiatric patients on antipsychotics such as Olanzapine and Clozapine. Obesity among treatment active psychiatric patients is associated with vitamin D insufficiency and deficiency, low adiponectin and leptin levels but higher resistin level.
The dynamic functions of social cues during children's word learning
Authors: Lee Crystal , Lew‐Williams Casey 
Published: October 2022

AbstractChildren learn words in a social environment, facilitated in part by social cues from caregivers, such as eye‐gaze and gesture. A common assumption is that social cues convey either perceptual or social information, depending on the age of the child. In this review of research on word learning and social cues during early childhood, we propose that (1) the functions of social cues are not categorically perceptual or social, and (2) social cues support word learning in four interdependent ways: by helping children to orient attention, extract relevant information, disambiguate referents, and understand others' referential intent. We conclude with specific recommendations for theory‐building and suggest that the dynamic and complex functions of social cues need to be accounted for in any complete theory of word learning.
Effects of consolidation of cooperative financial institutions in Japan: Evidence from meta‐frontier analysis
Authors: Yamori Nobuyoshi , Harimaya Kozo 
Published: October 2022

AbstractThis study investigates the regional differences in how consolidation has affected the efficiency of Shinkin banks, a representative cooperative financial institution in Japan, using the stochastic meta‐frontier approach based on cost and profit functions. The findings support the quiet life hypothesis that a significant negative relationship exists between efficiency‐adjusted Lerner indices and cost efficiency. By contrast, the relation between market power and profit efficiency is consistently positive. Moreover, independent Shinkin banks not involved in mergers exhibit higher costs and profit efficiency than other banks, suggesting that mergers can deteriorate efficiency.
Retroperitoneal recurrence of an ovarian juvenile granulosa cell tumor: A diagnostic challenge
Authors: Seabra Joana , Silva André , Santos Isa , Almeida Joana , Correia Lúcia , Correia Margarida 
Published: October 2022

SynopsisRetroperitoneal recurrence after excision of a juvenile granulosa cell tumor is rare and constitutes a diagnostic challenge, presenting with nonspecific symptoms and mimicking other conditions.
Implementation of a Global Health Equity fellowship established in partnership between an academic institution and governmental agency
Authors: Karwa Rakhi , Schellhase Ellen , Malati Christine Y. , Pastakia Sonak D. , Manji Imran , Samuel Jeffrey M. , Miller Monica L. 
Published: October 2022

AbstractHealth disparities exist globally in high‐income and low‐ and middle‐income countries. They are driven by social determinants of health (SDOH). While a role for pharmacists in addressing SDOH exists, a lack of structured postgraduate training limits pharmacists from being equipped to build innovative programs and contribute to health policy on SDOH in an impactful way. Postgraduate training, specifically, fellowships provides opportunities for pharmacists to develop the needed skills for working with SDOH. The Purdue University College of Pharmacy (PUCOP)‐United States Agency for International Development (USAID) Global Health Equity Fellowship was developed to meet this training need. This 2‐y fellowship represents a partnership between USAID and PUCOP. During the fellowship, time is split between USAID in Washington DC, PUCOP in Indianapolis, Indiana, and the Purdue Kenya Partnership (PKP) in Eldoret, Kenya. The fellowship was developed with a foundation of core values, the creation of a logic model, strategic partnerships, maintaining an adaptable structure, and intentional partner communication. Fellow outcomes were evaluated in three categories: engagement, education, and scholarship. Fellows completed 10 experiential opportunities between three sites and participated in the development of new and supported ongoing care programs and policy implementation in both local and international settings. Fellows completed the following educational outcomes: completed an online Master of Public Health (MPH) through Purdue Global, provided 13 educational presentations and lectures at various sites, and precepted a total of 12 PUCOP advanced pharmacy practice experience (APPE) students and 16 Kenyan pharmacy interns and Master of Pharmacy (MPharm) students. Fellows completed three publications and two abstracts at international conferences. This established training model provides pharmacists with a structured path to gain the knowledge, skills, and attitudes to be leaders in addressing Global Health Equity.
Gradual Self‐Training via Confidence and Volume Based Domain Adaptation for Multi Dataset Deep Learning‐Based Brain Metastases Detection Using Nonlocal Networks on MRI Images
Authors: Liew Andrea , Lee Chun Cheng , Subramaniam Valarmathy , Lan Boon Leong , Tan Maxine 
Published: October 2022

BackgroundResearch suggests that treatment of multiple brain metastases (BMs) with stereotactic radiosurgery shows improvement when metastases are detected early, providing a case for BM detection capabilities on small lesions.PurposeTo demonstrate automatic detection of BM on three MRI datasets using a deep learning‐based approach. To improve the performance of the network is iteratively co‐trained with datasets from different domains. A systematic approach is proposed to prevent catastrophic forgetting during co‐training.Study TypeRetrospective.PopulationA total of 156 patients (105 ground truth and 51 pseudo labels) with 1502 BM (BrainMetShare); 121 patients with 722 BM (local); 400 patients with 447 primary gliomas (BrATS). Training/pseudo labels/validation data were distributed 84/51/21 (BrainMetShare). Training/validation data were split: 121/23 (local) and 375/25 (BrATS).Field Strength/SequenceA 5 T and 3 T/T1 spin‐echo postcontrast (T1‐gradient echo) (BrainMetShare), 3 T/T1 magnetization prepared rapid acquisition gradient echo postcontrast (T1‐MPRAGE) (local), 0.5 T, 1 T, and 1.16 T/T1‐weighted‐fluid‐attenuated inversion recovery (T1‐FLAIR) (BrATS).AssessmentThe ground truth was manually segmented by two (BrainMetShare) and four (BrATS) radiologists and manually annotated by one (local) radiologist. Confidence and volume based domain adaptation (CAVEAT) method of co‐training the three datasets on a 3D nonlocal convolutional neural network (CNN) architecture was implemented to detect BM.Statistical TestsThe performance was evaluated using sensitivity and false positive rates per patient (FP/patient) and free receiver operating characteristic (FROC) analysis at seven predefined (1/8, 1/4, 1/2, 1, 2, 4, and 8) FPs per scan.ResultsThe sensitivity and FP/patient from a held‐out set registered 0.811 at 2.952 FP/patient (BrainMetShare), 0.74 at 3.130 (local), and 0.723 at 2.240 (BrATS) using the CAVEAT approach with lesions as small as 1 mm being detected.Data ConclusionImproved sensitivities at lower FP can be achieved by co‐training datasets via the CAVEAT paradigm to address the problem of data sparsity.Level of Evidence3Technical Efficacy Stage2
The impact of cerebrospinal fluid viral polymerase chain reaction testing on the management of adults with viral meningitis: A multi‐center retrospective study
Authors: Kim Myong Gyu , Gulholm Trine , Lennard Kate , Mirdad Feras , Overton Kristen , Maley Michael , Konecny Pamela , Andresen David , Post Jeffrey John ,   for the Sydney Partnerships for Health, Education, Research and Enterprise (SPHERE) Hospitals Infection Study Group
Published: October 2022

AbstractThe aim of this study was to evaluate the role of viral polymerase chain reaction (PCR) testing in patients with aseptic meningitis and identify opportunities for improvement in clinical management. All cerebrospinal fluid samples collected in 1 year from four teaching hospitals in Sydney, Australia, were reviewed. Patients with aseptic meningitis were selected, and clinical and diagnostic features, hospital length of stay (LOS), and treatment were analyzed. Identifying a cause by viral PCR did not reduce hospital LOS (median 3 days) or antibiotic use (median 2 days), but the turnaround time of the PCR test correlated with LOS (Rs = 0.3822, p = 0.0003). Forty‐one percent of patients received intravenous acyclovir treatment, which was more frequent in patients admitted under neurologists than infectious diseases physicians (56% vs. 24%; p = 0.013). The majority of patients did not have investigations for alternative causes of aseptic meningitis such as human immunodeficiency virus and syphilis if the viral PCR panel was negative. The benefit of PCR testing in aseptic meningitis in adults in reducing LOS and antibiotic use is unclear. The reasons for unnecessary aciclovir use in meningitis syndromes require further assessment.
Current immunoassays and detection of antibodies elicited by Omicron SARS‐CoV‐2 infection
Authors: Migueres Marion , Chapuy‐Regaud Sabine , Miédougé Marcel , Jamme Thibaut , Lougarre Catherine , Da Silva Isabelle , Pucelle Mélanie , Staes Laetitia , Porcheron Marion , Diméglio Chloé , Izopet Jacques 
Published: October 2022

AbstractThe present study aimed to determine whether current commercial immunoassays are adequate for detecting anti‐Omicron antibodies. We analyzed the anti‐SARS‐CoV‐2 antibody response of 23 unvaccinated individuals 1–2 months after an Omicron infection. All blood samples were tested with a live virus neutralization assay using a clinical Omicron BA.1 strain and four commercial SARS‐CoV‐2 immunoassays. We assessed three anti‐Spike immunoassays (SARS‐CoV‐2 IgG II Quant [Abbott S], Wantaï anti‐SARS‐CoV‐2 antibody ELISA [Wantaï], Elecsys Anti‐SARS‐CoV‐2 S assay [Roche]) and one anti‐Nucleocapsid immunoassay (Abbott SARS‐CoV‐2 IgG assay [Abbott N]). Omicron neutralizing antibodies were detected in all samples with the live virus neutralization assay. The detection rate of the Abbott S, Wantai, Roche, and Abbott N immunoassays were 65.2%, 69.6%, 86.9%, and 91.3%, respectively. The sensitivities of Abbott S and Wantai immunoassays were significantly lower than that of the live virus neutralization assay (p = 0.004, p = 0.009; Fisher's exact test). Antibody concentrations obtained with anti‐S immunoassays were correlated with Omicron neutralizing antibody concentrations. These data provide clinical evidence of the loss of performance of some commercial immunoassays to detect antibodies elicited by Omicron infections. It highlights the need to optimize these assays by adapting antigens to the circulating SARS‐CoV‐2 strains.
Power ultrasound treatment of Viognier grapes as a tool to increase the aromatic potential of wines
Authors: Labrador Fernández Lara , Díaz‐Maroto M. Consuelo , Pérez Porras Paula , Bautista‐Ortín Ana Belén , Alañón M. Elena , Gómez‐Plaza Encarna , Pérez‐Coello M. Soledad 
Published: October 2022

AbstractBACKGROUNDHigh‐power ultrasound is a novel and non‐thermal technique normally used in red vinification to increase the extraction of phenolic compounds. However, few studies have been carried out on its effect on the extraction of aroma compounds and their precursors in white grapes. This study evaluates the effect of high‐power ultrasound at winery scale in the maceration of Viognier grapes on the content of varietal volatile compounds (free and glycosidically bound) in musts and wines, in comparison with wines from direct pressing and from short skin maceration.RESULTSThe pre‐fermentative ultrasound treatment of the grapes produced an increase in most of the varietal compounds of musts and wines, both in the free fraction and in the bound one, especially in the C6 alcohols, terpenes and norisoprenoids, some of them of sensory relevance, while the effect on esters and lactones was less evident. Ultrasound maceration allowed us to obtain wines of higher aromatic intensity, with a more pronounced varietal character.CONCLUSIONThe pre‐fermentative ultrasound treatment of Viognier grapes increases the aromatic potential of the wines, as it favors the extraction of free and bound varietal volatile compounds. In addition, it allows the maceration time of the grapes to be reduced compared to conventional pre‐fermentation techniques, thus avoiding oxidative processes that could negatively affect the aroma of the wines. © 2022 Society of Chemical Industry.
Prevalence of helminths in fresh vegetables: a narrative literature review
Authors: da Costa Dantas Lívia Maria , de Medeiros Maia Cláudio Márcio , da Silva Chaves Damasceno Karla Suzanne Florentino , Mont'Alverne Jucá Seabra Larissa , Chaves Gabriela , de Assis Cristiane Fernandes , de Sousa Júnior Francisco Canindé 
Published: October 2022

AbstractThe consumption of fresh vegetables is related to healthy lifestyle habits present in culinary preparations in different regions. The presence of pathogenic parasites in these foods can cause gastrointestinal disorders. Thus, the objective of the present study was to carry out a narrative review of the literature on the prevalence of helminths in fresh vegetable samples. The analysis of the studies published from 2016 to 2022 showed that hookworms andAscaris lumbricoidesare the most common pathogenic helminths in fresh vegetable samples, with a prevalence of up to 73.8% and 55.1%, respectively. In addition, studies have shown associations between the presence of helminths and pathogenic protozoa. The results obtained in this review indicate the urgent need to implement actions at all stages of the vegetable production chain, from the water used in planting irrigation to cleaning before sale to the final consumer. © 2022 Society of Chemical Industry.
Socioeconomic outcomes of ecological restoration projects and parallel policies: A case‐study of the agro‐pastoral ecotone in northern China
Authors: Dang Dongliang , Li Xiaobing , Li Shengkun , Li Xiang , Lyu Xin , Dou Huashun , Li Mengyuan , Liu Siyu , Wang Kai 
Published: October 2022

AbstractClarifying the socioeconomic processes and outcomes of ecological restoration projects (ERPs) is important to the ERP's effectiveness or performance. In addition, ERPs are often carried out in parallel with other policies and may have complex and integrated impacts on social‐ecological systems. However, few studies have included the impact of such parallel policies in their analysis. Here, the agro‐pastoral ecotone in northern China, which contains several national ERPs and grass‐based livestock husbandry promotion policies, was used to analyze the socioeconomic outcomes in the context of multi‐policies. Specifically, we developed a framework to integrate linkages between multiple ecosystem management policies, livelihood assets, activities, and socioeconomic outcomes and used a structural equation model to distinguish the contributions and pathways of multi‐policies to socioeconomic outcomes. Thus, our framework follows the cascading effects of multi‐policies from the perspective of rural livelihoods while highlighting the diverse socioeconomic impacts. The results showed that grass‐based livestock husbandry and the local economy had a more significant impact on rural income compared to ERPs. However, it is worth noting that the agricultural structure has also changed with the development of grass‐based livestock husbandry, which may have a negative feedback effect on the ERP effectiveness. In other words, complementarity and offsetting can occur between ERPs and parallel policies. Our study contributes to a comprehensive understanding of the social‐ecological processes and outcomes, thereby providing new methods and insights for future scientific policymaking.