bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of the relative abundance of rodents in landscapes dominated by Eucalyptus plantations
Authors: Teixeira Daniela , Magalhães Ana , Ares-Pereira Guilherme , Lima Cátia , Castro Guilherme , Camarinha Cláudia , Fonseca Carlos , Rosalino Luís Miguel 
Published: March 2022

Abstract
Forestry plantations have increased considerably over recent decades to fulfil human demand for wood, pulp and paper. Eucalyptus globulus Labill is one of the most abundant plantation species, particularly in Europe, where its largest presence is in Portugal. Furthermore, plantations in Mediterranean areas, such as Portugal, frequently suffer from forest fires, and thus it is crucial to understand their impacts on vertebrates. This is especially relevant for some species, like small mammals, that use landscapes at smaller scales for which even small changes in forest cover may have a profound effect. In this study, we evaluate the effects of several environmental, disturbance and habitat drivers on the relative abundance of rodents (Muridae) in Eucalyptus plantations in central Portugal. Specimen capture took place across two seasons and at eight study sites representing six different stages of Eucalyptus plantations and two native forests from 2019 to 2020. Using a structural equation modelling approach, we show that the relative abundance of rodents was promoted by recent wildfire events and was higher in areas where carnivores and wild boar were more abundant. By contrast, abundant deer and increased percentages of herbaceous or litter cover and bare soil limited the abundance of rodents. We did not detect a significant relationship between Eucalyptus plantations and the relative abundance of rodents. The presence of other species, either by direct contact (carnivores) or by inducing habitat changes (ungulates), and vegetation structure, likely linked to plantation management or fire regime, are the more important factors dictating the population dynamics of rodents across plantation forests in central Portugal.
Data-adaptive global full-waveform inversion
Authors: Thrastarson Solvi , van Herwaarden Dirk-Philip , Krischer Lion , Boehm Christian , van Driel Martin , Afanasiev Michael , Fichtner Andreas 
Published: March 2022

SUMMARYWe present a novel approach to global-scale full-waveform inversion (FWI) that can reduce computational cost by over an order of magnitude, compared to previously published methods, without sacrificing physical and mathematical rigour. This is based on data-adaptation, and thereby application-oriented specialization, on two complementary levels. On the simulation level, we exploit the approximate azimuthal symmetry of seismic wavefields by implementing wavefield-adapted meshes and discrete adjoints, thereby lowering numerical simulation cost. On the measurement level, we use a quasi-stochastic approach where variable mini-batches of data are used during an iterative misfit minimization in order to promote a parsimonious exploitation of data. In addition to the methodological developments, we present an inversion of long-period (100–200 s) seismic waveforms from 1179 earthquakes for 3-D whole-mantle structure. The computational cost of the 72 iterations in the inversion approximately equals one third of a single iteration using an FWI approach with widely used cubed-sphere-based meshes and non-stochastic gradient optimization. The resulting LOng-Wavelength earth model (LOWE) constitutes the first global FWI constructed entirely from a spherically symmetric initial mantle structure. While mostly serving as a showcase for the method, LOWE contains a wealth of regional-scale structures that compare well to earlier tomographic images. Being conservatively smooth and based on minimal assumptions, it may therefore serve as starting model for future inversions at shorter period or smaller scales.
Doege Potter syndrome presenting as multiple fibrous tumours of the chest
Authors: Donato Britton B , Sewell Marisa A , Sen Ayan , Beamer Staci E 
Published: March 2022

Abstract
Doege Potter syndrome is a rare condition causing non-islet cell paraneoplastic hypoglycaemia associated with fibrous tumours, which can be both benign and malignant. The vast majority are solitary and located within the chest. Non-islet cell tumour-induced hypoglycaemia, as in Doege Potter syndrome, is quite rare and occurs around 4 times less often than islet cell-associated paraneoplastic hypoglycaemia. We present a case of Doege Potter syndrome with severe hypoglycaemia in conjunction with multiple recurrent fibrous tumours of the lung and pleura.
Saudi pharmacy students’ perceived knowledge and attitude on their role in public health services
Authors: Alfadl Abubakr Abdelraouf , Siddeeg Khalid , Anaam Mohammed Saif , Alharbi Rakan A , Aljutayli Meshal A , Alsaeed Hamad M 
Published: March 2022

Abstract

Objectives
This study aimed to explore the preparedness of pharmacy students to actively participate in public health services by examining their attitude towards and knowledge about the national public health programmes (NPHPs).

Methods
A cross-sectional study was conducted using an online questionnaire survey of the students in Unaizah College of Pharmacy (UCP) and College of Pharmacy Main Campus (CPMC), Qassim University, between October 2019 and February 2020.

Key findings
A total of 100 out of 125 students responded to the questionnaire at a response rate of 80%. While the majority (77%) of the participants agreed on the necessity for pharmacists to know about the NPHPs, 71% reported they did not learn about National Health Policy in their pharmacy curriculum. Also, a small number of pharmacy students, at 16%, believed that their current knowledge about the NPHPs was sufficient or very sufficient. Lastly, 81% of the participants felt that they had an important or very important role to play in the NPHPs.

Conclusions
The majority of the participants expressed interest in more education on public health during their pharmacy education. Their interest supports the advancement of public health education to facilitate greater involvement of pharmacists in public health services.
Decolonization of Postcolonial Africa: A Structural Justice Project More Radical than Transitional Justice
Authors: Sesay Mohamed 
Published: March 2022

ABSTRACT
This article seeks to contribute to the debate as to whether the field of transitional justice can or should take on decolonization as one of its desired goals. I argue that efforts to incorporate decolonization within the normative and functional remit of the field are politically, practically and conceptually untenable. In addition to the high implausibility of the field undertaking self-radicalization within the existing (neo)liberal Euro-American order, transitional justice is based on principles of responsibility and accountability that are fundamentally different from decolonization construed as structural justice. In particular, whereas transitional justice is essentially an intervention to restore the integrity of the existing normative and social order, the decolonization project seeks to interrogate and dismantle some parts of the system being legitimated, if not the entire system. Therefore, framing such a project as transitional justice risks depoliticizing and minimizing its socially transformative essence which is long established in the history of political liberation movements of the postcolony. Although this is a case study of Sierra Leone’s almost 20-year experience of transitional justice, I aim to connect the field with the recent critical turn to the decolonization of postcolonial Africa.
In vivo efficacy of WCK 6777 (ertapenem/zidebactam) against carbapenemase-producing Klebsiella pneumoniae in the neutropenic murine pneumonia model
Authors: Gethers Matthew , Chen Iris , Abdelraouf Kamilia , Nicolau David P 
Published: March 2022

Abstract

Objectives
Ertapenem has proven to be an effective antimicrobial; however, increasing enzyme-mediated resistance has been noted. Combination with zidebactam, a β-lactam enhancer, is restorative. Human-simulated regimens (HSRs) of ertapenem and zidebactam alone and in combination (WCK 6777; 2 g/2 g q24h) were assessed for efficacy against carbapenemase-producing Klebsiella pneumoniae (CP-KP) in the pneumonia model.

Methods
Infected ICR mice were rendered neutropenic and exposed to various doses of ertapenem and zidebactam alone and in combination to develop the HSRs that were subsequently confirmed in additional pharmacokinetic studies. Twenty-one CP-KP (KPC or OXA-48-like producers) with WCK 6777 MICs of 1–8 mg/L were utilized. Mice were treated for 24 h with saline or HSRs of ertapenem, zidebactam and WCK 6777. Efficacy was defined as change in mean lung bacterial density relative to 0 h.

Results
Confirmatory pharmacokinetic analysis showed agreement between predicted human exposures (%fT&gt;MIC) and those achieved in vivo for all three HSRs. The 0 h bacterial density across all isolates was 6.69 ± 0.31 log10 cfu/lungs. At 24 h, densities increased by 2.57 ± 0.50, 2.2 ± 0.60 and 2.05 ± 0.71 log10 cfu/lungs in the 24 h control, ertapenem HSR and zidebactam HSR groups, respectively. Overall, 18/21 of the isolates exposed to the WCK 6777 HSR displayed a killing profile that exceeded the translational benchmark for efficacy of a 1 log10 cfu reduction. Among the remaining three isolates, two displayed ∼0.5 log10 kill and stasis was observed in the third.

Conclusions
Human-simulated exposures of WCK 6777 demonstrated potent in vivo activity against CP-KP, including those with WCK 6777 MICs up to 8 mg/L.
Spatio-Temporal Dynamics of a Dieldrin Resistance Gene in Aedes albopictus and Culex quinquefasciatus Populations From Reunion Island
Authors: Lebon Cyrille , Alout Haoues , Zafihita Stanislas , Dehecq Jean-Sébastien , Weill Mylène , Tortosa Pablo , Atyame Célestine 
Published: March 2022

Abstract
The control of mosquito populations using insecticides is increasingly threatened by the spread of resistance mechanisms. Dieldrin resistance, conferred by point mutations in the Rdl gene encoding the γ-aminobutyric acid receptor, has been reported at high prevalence in mosquito populations in response to selective pressures. In this study, we monitored spatio-temporal dynamics of the resistance-conferring RdlR allele in Aedes (Stegomyia) albopictus (Skuse, 1895) and Culex (Culex) quinquefasciatus (Say, 1823) populations from Reunion Island. Specimens of both mosquito species were sampled over a 12-month period in three cities and in sites located at lower (&lt;61 m) and higher (between 503 and 564 m) altitudes. Mosquitoes were genotyped using a molecular test detecting the alanine to serine substitution (A302S) in the Rdl gene. Overall, the RdlR frequencies were higher in Cx. quinquefasciatus than Ae. albopictus. For both mosquito species, the RdlR frequencies were significantly influenced by location and altitude with higher RdlR frequencies in the most urbanized areas and at lower altitudes. This study highlights environmental factors that influence the dynamics of insecticide resistance genes, which is critical for the management of insecticide resistance and the implementation of alternative and efficient vector control strategies.
Anti-inflammatory, anti-oxidant and anti-apoptotic effects of olive leaf extract in cardiac tissue of diabetic rats
Authors: Asghari Ali Akbar , Mahmoudabady Maryam , Shabab Sadegh , Niazmand Saeed 
Published: March 2022

Abstract

Objectives
Inflammatory process and apoptosis are involved in the pathogenesis of cardiac injury and oxidative damage caused by diabetes mellitus. The cardioprotective effects of standardized aqueous ethanolic olive leaf extract (OLE), metformin (as a cardiovascular protective agent) and valsartan (as an angiotensin receptor blocker) in the streptozotocin-induced diabetic rats were evaluated.

Methods
Wistar rats divided into control, diabetic, OLE-treated (100, 200 and 400 mg/kg), metformin (300 mg/kg)-treated, valsartan (30 mg/kg)-treated and metformin/valsartan-treated diabetic groups. Biochemical parameters, including malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activates, and the total contents of thiol were measured, and histopathological and gene expression studies were done on cardiac tissues. Fasting blood sugar (FBS) and cardiac injury markers were examined in serum.

Key findings
FBS; the serum levels of lactate dehydrogenase (LDH), creatine kinase-muscle/brain (CK-MB), aspartate aminotransferase (AST); and heart tissue MDA levels due to diabetes were significantly alleviated by OLE treatment (effect size; ηp2 = 0.934, 0.888, 0.848, 0.888 and 0.879, respectively), and SOD and CAT activity and the thiol content in heart tissue were significantly increased (effect size; ηp2 = 0.770, 0.749 and 0.753, respectively). Interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α) and the number of infiltrating inflammatory cells were reduced in cardiac tissues of OLE-treated groups compared with the diabetic rats (effect size; ηp2 = 0.969 and 0.949, respectively). OLE up-regulated BCL2 gene expression and down-regulated BAX gene expression in cardiac tissue (effect size; ηp2= 0.490 and 0.522, respectively).

Conclusion
OLE in a dose-dependent manner ameliorates cardiac damage in diabetic cardiomyopathy, perhaps through attenuating inflammation, oxidative stress and apoptosis.
Interactions of melatonin, reactive oxygen species, and nitric oxide during fruit ripening: an update and prospective view
Authors: Corpas Francisco J , Rodríguez-Ruiz Marta , Muñoz-Vargas María A , González-Gordo Salvador , Reiter Russel J , Palma José M 
Published: March 2022

Abstract
Fruit ripening is a physiological process that involves a complex network of signaling molecules that act as switches to activate or deactivate certain metabolic pathways at different levels, not only by regulating gene and protein expression but also through post-translational modifications of the involved proteins. Ethylene is the distinctive molecule that regulates the ripening of fruits, which can be classified as climacteric or non-climacteric according to whether or not, respectively, they are dependent on this phytohormone. However, in recent years it has been found that other molecules with signaling potential also exert regulatory roles, not only individually but also as a result of interactions among them. These observations imply the existence of mutual and hierarchical regulations that sometimes make it difficult to identify the initial triggering event. Among these ‘new’ molecules, hydrogen peroxide, nitric oxide, and melatonin have been highlighted as prominent. This review provides a comprehensive outline of the relevance of these molecules in the fruit ripening process and the complex network of the known interactions among them.
Absorption variability of the highly obscured active galactic nucleus NGC 4507
Authors: Jana Arghajit , Ricci Claudio , Naik Sachindra , Tanimoto Atsushi , Kumari Neeraj , Chang Hsiang-Kuang , Nandi Prantik , Chatterjee Arka , Safi-Harb Samar 
Published: March 2022

ABSTRACTWe present a detailed study of the highly obscured active galaxy NGC 4507, performed using four Nuclear Spectroscopic Telescope Array (NuSTAR) observations carried out between May and August in 2015 (∼130 ks in total). Using various phenomenological and physically motivated torus models, we explore the properties of the X-ray source and those of the obscuring material. The primary X-ray emission is found to be non-variable, indicating a stable accretion during the period of the observations. We find the equatorial column density of the obscuring materials to be ∼2 × 1024 cm−2 while the line-of-sight column density to be ∼7–8 × 1023 cm−2. The source is found to be deeply buried with the torus covering factor of ∼0.85. We observe variability in the line-of-sight column density on a time-scale of &lt;35 d. The covering factor of the Compton-Thick material is found to be ∼0.35 in agreement with the results of recent X-ray surveys. From the variability of the line-of-sight column density, we estimate that the variable absorbing material is likely located either in the BLR or in the torus.
The OmegaWhite survey for short-period variable stars – VI. Open clusters
Authors: Toma R , Ramsay G , Jeffery C S , Macfarlane S A , Woudt P , Groot P J 
Published: March 2022

ABSTRACT
Using light curves with ∼3 min cadence and a duration of 2 h made using the OmegaWhite survey, we present the results of a search for short-period variable stars in the field of 20 open clusters. We identified 92 variable stars in these fields. Using a range of cluster member catalogues and Gaia EDR3 data, we have determined that 10 are cluster members and 2 more are probable members. Based on their position on the Gaia HRD and their photometric periods, we find that most of these are δ Sct stars. We obtained low-resolution optical spectroscopy of some of these cluster members and field stars. We discuss the cluster variable stars in the context of δ Sct stars in other open clusters.
Stellar proper motions in the outskirts of classical dwarf spheroidal galaxies withGaiaEDR3
Authors: Qi Yuewen , Zivick Paul , Pace Andrew B , Riley Alexander H , Strigari Louis E 
Published: March 2022

ABSTRACTWe use Gaia EDR3 data to identify stars associated with six classical dwarf spheroidals (dSphs) (Draco, Ursa Minor, Sextans, Sculptor, Fornax, Carina) at their outermost radii, beyond their nominal King stellar limiting radius. For all of the dSphs examined, we find radial velocity matches with stars residing beyond the King limiting radius and with ${\gt}50{{\ \rm per\ cent}}$ astrometric probability (four in Draco, two in Ursa Minor, eight in Sextans, two in Sculptor, 12 in Fornax, and five in Carina), indicating that these stars are associated with their respective dSphs at high probability. We compare the positions of our candidate ‘extra-tidal’ stars with the orbital tracks of the galaxies, and identify stars, both with and without radial velocity matches, that are consistent with lying along the orbital track of the satellites. However, given the small number of candidate stars, we cannot make any conclusive statements about the significance of these spatially correlated stars. Cross matching with publicly available catalogues of RR Lyrae, we find one RR Lyrae candidate with ${\gt}50{{\ \rm per\ cent}}$ astrometric probability outside the limiting radius in each of Sculptor and Fornax, two such candidates in Draco, nine in Ursa Minor, seven in Sextans, and zero in Carina. Follow-up spectra on all of our candidates, including possible metallicity information, will help confirm association with their respective dSphs, and could represent evidence for extended stellar haloes or tidal debris around these classical dSphs.
The dependence of theoretical synthetic spectra on α-enhancement in young, binary stellar populations
Authors: Byrne C M , Stanway E R , Eldridge J J , McSwiney L , Townsend O T 
Published: March 2022

ABSTRACT
The enhancement of α elements such as oxygen is an important phase in the chemical evolution of the early Universe, with nebular material becoming enriched in these elements sooner than iron. Here, we present models which incorporate stellar spectra with α-enhanced compositions, focusing on the impact on the integrated light of young stellar populations, including those with large binary star fractions using the Binary Populations and Spectral Synthesis (bpass) framework, while using Solar-scaled stellar evolution models. We find that broad spectrum outputs such as production of ionizing flux, the ultraviolet spectral slope and optical colours are only weakly affected by a change in $[\alpha /\rm {Fe}]$. A number of features such as ultraviolet line indices (e.g. at 1719 and 1853 Å) and optical line indices (such as MgB) are sensitive to such changes in composition for a continuously star-forming population and a single starburst population respectively. We find that at ages of more than 1 Gyr, α-enhanced stellar populations appear bluer than their Solar-scaled counterparts, and show expected sensitivity of optical line indices to composition, in agreement with previous work. The ultraviolet stellar absorption lines are relatively insensitive to subtleties in the abundances ratios, although with sufficient measurement precision, a combination of UV line indices may enable a simultaneous measurement of total metallicity mass fraction and $[\alpha /\rm {Fe}]$ in young stellar populations. The output models are designated as bpass v2.3 and made available to the community with the aim of assisting interpretation of observations of high-redshift galaxies with the James Webb Space Telescope.
Predictions for complex distributions of stellar elemental abundances in low-mass galaxies
Authors: Patel Preet B , Loebman Sarah R , Wetzel Andrew , Faucher-Giguère Claude-André , El-Badry Kareem , Bailin Jeremy 
Published: March 2022

ABSTRACTWe investigate stellar elemental abundance patterns at $z$ = 0 in eight low-mass ($M_{*}=10^{6}{-}10^{9}\ \text{M}_{\odot }$) galaxies in the Feedback in Realistic Environments cosmological simulations. Using magnesium (Mg) as a representative α-element, we explore stellar abundance patterns in magnesium-to-iron ([Mg/Fe]) versus iron-to-hydrogen ([Fe/H]), which follow an overall monotonic trend that evolved slowly over time. Additionally, we explore three notable secondary features in enrichment (in three different case-study galaxies) that arise from a galaxy merger or bursty star formation. First, we observe a secondary track with a lower [Mg/Fe] than the main trend. At $z$ = 0, stars from this track are predominantly found within 2–6 kpc of the centre; they were accreted in a 1:3 total-mass-ratio merger ∼0.4 Gyr ago. Second, we find a distinct elemental bimodality that forms following a strong burst in star formation in a galaxy at $t_{\text{lookback}}\, \sim 10$ Gyr. This burst quenched star formation for ∼0.66 Gyr, allowing Type Ia supernovae to enrich the system with iron (Fe) before star formation resumed. Third, we examine stripes in enrichment that run roughly orthogonal to the dominant [Mg/Fe] versus [Fe/H] trend; these stripes correspond to short bursts of star formation during which core-collapse supernovae enrich the surrounding medium with Mg (and Fe) on short time-scales. If observed, these features would substantiate the utility of elemental abundances in revealing the assembly and star-formation histories of dwarf galaxies. We explore the observability of these features for upcoming spectroscopic studies. Our results show that precise measurements of elemental abundance patterns can reveal critical events in the formation histories of low-mass galaxies.
AI-driven spatio-temporal engine for finding gravitationally lensed type Ia supernovae
Authors: Kodi Ramanah Doogesh , Arendse Nikki , Wojtak Radosław 
Published: March 2022

ABSTRACT
We present a spatio-temporal AI framework that concurrently exploits both the spatial and time-variable features of gravitationally lensed supernovae in optical images to ultimately aid in future discoveries of such exotic transients in wide-field surveys. Our spatio-temporal engine is designed using recurrent convolutional layers, while drawing from recent advances in variational inference to quantify approximate Bayesian uncertainties via a confidence score. Using simulated Young Supernova Experiment (YSE) images of lensed and non-lensed supernovae as a showcase, we find that the use of time-series images adds relevant information from time variability of spatial light distribution of partially blended images of lensed supernova, yielding a substantial gain of around 20 per cent in classification accuracy over single-epoch observations. Preliminary application of our network to mock observations from the Legacy Survey of Space and Time (LSST) results in detections with accuracy reaching around 99 per cent. Our innovative deep learning machinery is versatile and can be employed to search for any class of sources that exhibit variability both in flux and spatial distribution of light.