bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preconception Care for Women with Medicaid: Self-report vs. Claims-based Utilization Measures
Authors: Stulberg Debra B. , Schumm L. Philip , Schueler Kellie , Giurcanu Mihai , Peek Monica 
Published: July 2022

AbstractBackgroundPreconception care may improve perinatal outcomes and reduce disparities, but there is no standard population measure of preconception care utilization (PCU).ObjectiveWe compared claims-based PCU from Medicaid Analytic Extract (MAX) data to self-report in the Pregnancy Risk Assessment and Monitoring System (PRAMS) survey.MethodsAmong Medicaid-enrolled women ages 15-45 with births during 2012, we identified preconception services in MAX using 55 ICD9 codes published by Health and Human Services. We estimated the proportion reporting preconception care from 26 PRAMS states and compared this to the states’ proportion who received services in MAX. We fit mixed-effects logistic regression models of the probability of PCU on demographic factors (age, race/ethnicity) and diagnoses (depression, diabetes, or hypertension), separately for each dataset. Finally, we computed the population proportions receiving care by state (MAX) and the empirical Bayes means of the state-level effects (MAX and PRAMS).ResultsAmong 652,929 deliveries in MAX from the included states, 28.1% received at least one preconception service. In PRAMS, 23.6% (95% CI [22.1, 25.3]) of Medicaid-covered respondents reported preconception care. In both datasets, PCU rates were higher for Black non-Hispanic vs. White non-Hispanic women (PRAMS OR 2.05 [1.60, 1.62]; MAX OR 1.51 [1.49, 1.54]) and for those with diabetes (PRAMS OR 1.82 [1.16, 2.85]; MAX OR 1.34 [1.29, 1.40]) or hypertension (OR 1.85 [1.41, 2.44]; MAX OR 1.22 [1.18, 1.27]). In PRAMS, Asian (OR 3.37 [2.28, 4.98]) and Hispanic women (OR 2.07 [1.5, 2.80]) were more likely to report PCU than White non-Hispanic women, but in MAX they were less likely to receive services. The correlation between the PRAMS state-specific effects and those from MAX was 0.31 (p = 0.124).ConclusionsClaims-based estimates of PCU are moderately concordant with self-reported rates at the state level; however, rates measured through Medicaid claims vs. self-report diverge in some groups.SynopsisStudy QuestionHow do Medicaid claims-based measures of preconception care utilization compare to self-reported receipt of preconception counseling among Medicaid-covered respondents in the Pregnancy Risk Assessment and Monitoring System (PRAMS) survey?What’s already knownPRAMS provides population-level estimates of preconception care utilization, while claims-based measures quantify specific services received.What this study addsClaims-based preconception care utilization among the Medicaid population varies by race (Black/White) and diagnosis of diabetes or hypertension in similar patterns as self-report in PRAMS, but ethnicity (Hispanic/non-Hispanic) and depression demonstrate divergent patterns between the two data sources. State-level variation in preconception care utilization is greater in claims data. Both data sources can be used by researchers with an understanding of their methodological benefits and limitations.
Evolutionary Diversification of MethanotrophicCa. Methanophagales (ANME-1) and Their Expansive Virome
Authors: Laso-Pérez Rafael , Wu Fabai , Crémière Antoine , Speth Daan R. , Magyar John S. , Krupovic Mart , Orphan Victoria J. 
Published: July 2022

Abstract‘CandidatusMethanophagales’ (ANME-1) is a major order-level clade of archaea responsible for methane removal in deep-sea sediments through the anaerobic oxidation of methane. Yet the extent of their diversity and factors which drive their dynamics and evolution remain poorly understood. Here, by sampling hydrothermal rocks and sediments, we expand their phylogenetic diversity and characterize a new deep-branching, thermophilic ANME-1 family, ‘CandidatusMethanospirareceae’ (ANME-1c). They are phylogenetically closest to the short-chain-alkane oxidizers ‘CandidatusSyntrophoarchaeales’ and ‘CandidatusAlkanophagales’, and encode ancestral features including a methyl coenzyme M reductase chaperone McrD and a hydrogenase complex. Global phylogeny and near-complete genomes clarified that the debated hydrogen metabolism within ANME-1 is an ancient trait that was vertically inherited but differentially lost during lineage diversification. Our expanded genomic and metagenomic sampling allowed the discovery of viruses constituting 3 new orders and 16 new families that so far are exclusive to ANME-1 hosts. These viruses represent 4 major archaeal virus assemblages, characterized by tailless icosahedral, head-tailed, rod-shaped, and spindle-shaped virions, but display unique structural and replicative signatures. Exemplified by the analyses of thymidylate synthases that unveiled a virus-mediated ancestral process of host gene displacement, this expansive ANME-1 virome carries a large gene repertoire that can influence their hosts across different timescales. Our study thus puts forth an emerging evolutionary continuum between anaerobic methane and short-chain-alkane oxidizers and opens doors for exploring the impacts of viruses on the dynamics and evolution of the anaerobic methane-driven ecosystems.
OUGene 2.0: An updated disease-associated over- and under-expressed gene database by mining full-text articles
Authors: Qin Erdi , Pan Xiaoyong , Shen Hong-Bin 
Published: July 2022

AbstractMany diseases are closely associated with over- or under-expressed genes. In order to cover more up to date associations between over- or under-expressed genes and various diseases, we develop an updated database OUGENE 2.0 for disease-associated over- and under-expressed genes by automatic full-text mining. In total, the new OUGene 2.0 includes 197,236 associations between 12,672 diseases and 11,542 over- or under-expressed genes, which increases by about 5 folds compared to the previous version of OUGene. A novel method for rescaling the raw score based on support evidences is designed to prioritize the mined associations. OUGene 2.0 provides a holistic view of disease-gene associations and it supports user-friendly data exploration at www.csbio.sjtu.edu.cn/bioinf/OUGene for academic use.
Polyploidy, regular patterning of genome copies, and unusual control of DNA partitioning in the Lyme disease spirochete
Authors: Takacs Constantin N. , Wachter Jenny , Xiang Yingjie , Karaboja Xheni , Ren Zhongqing , Scott Molly , Stoner Matthew R. , Irnov Irnov , Jannetty Nicholas , Rosa Patricia A. , Wang Xindan , Jacobs-Wagner Christine 
Published: July 2022

ABSTRACTBorrelia burgdorferi, the tick-transmitted spirochete agent of Lyme disease, has a highly segmented genome with a linear chromosome and various linear or circular plasmids. Here, by imaging several chromosomal loci and 16 distinct plasmids, we show thatB. burgdorferiis polyploid during growth in culture and that the number of genome copies decreases during stationary phase.B. burgdorferiis also polyploid inside fed ticks and chromosome copies are regularly spaced along the spirochete’s length in both growing cultures and ticks. This patterning involves the conserved DNA partitioning protein ParA whose localization is controlled by a potentially phage-derived protein, ParZ, instead of its usual partner ParB. ParZ binds its own coding region and acts as a centromere-binding protein. While ParA works with ParZ, ParB controls the localization of the condensin, SMC. Together, the ParA/ParZ and ParB/SMC pairs ensure faithful chromosome inheritance. Our findings underscore the plasticity of cellular functions, even those as fundamental as chromosome segregation.
ArtinM Cytotoxicity in B cells derived from Non-Hodgkin’s Lymphoma is regulated by CD45 phosphatase activity and Src family kinases
Authors: Barboza Bruno Rafael , de Oliveira Thomaz Sandra Maria , de Carvalho Airton , Espreafico Enilza Maria , Miyamoto Jackson Gabriel , Tashima Alexandre Keiji , Camacho Maurício Frota , Zelanis André , Roque-Barreira Maria Cristina , da Silva Thiago Aparecido 
Published: July 2022

AbstractReceptors on the immune cell surface have a variety of glycans that may account for the immunomodulation induced by lectins, which have a carbohydrate recognition domain (CRD) that binds to monosaccharides or oligosaccharides in a specific manner. ArtinM, a D-mannose-binding lectin obtained fromArtocarpus heterophyllus, has affinity for the N-glycans core. Immunomodulation by ArtinM toward the Th1 phenotype occurs via its interaction with TLR2/CD14 N-glycans on antigen-presenting cells, as well as recognition of CD3γ N-glycans on murine CD4+ and CD8+ T cells. ArtinM exerts a cytotoxic effect on Jurkat human leukemic T cell line and human myeloid leukemia cell line (NB4). The current study evaluated the effects of ArtinM on murine and human B cells derived from non-Hodgkin’s lymphoma. We found that murine B cells are recognized by ArtinM via the CRD, and the ArtinM stimulus did not augment the proliferation rate or production of IL-2. However, murine B cells incubation with ArtinM augmented the rate of apoptosis, and this cytotoxic effect of ArtinM was also seen in human B cell lines sourced from non-Hodgkin’s lymphoma Raji cell line. This cytotoxic effect was inhibited by the phosphatase activity of CD45 on Lck, and the protein kinases of the Src family contribute to cell death triggered by ArtinM.
TMEM164 is an acyltransferase that forms ferroptotic polyunsaturated ether phospholipids
Authors: Reed Alex , Ware Timothy , Li Haoxin , Bazan J. Fernando , Cravatt Benjamin F. 
Published: July 2022

AbstractFerroptosis is an iron-dependent form of cell death driven by the oxidation of polyunsaturated (PUFA) phospholipids. Large-scale genetic screens have pointed to a specialized role for PUFA ether phospholipids (ePLs) in promoting ferroptosis. Our understanding of the enzymes involved in PUFA ePL production, however, remains incomplete. Here we show using a combination of pathway mining of genetic dependency maps, AlphaFold-guided structure predictions, and targeted lipidomics that the uncharacterized transmembrane protein TMEM164 – genetic ablation of which has been shown to protect cells from ferroptosis – is a cysteine active-center enzyme that selectively transfers C20:4 acyl chains from phosphatidylcholine to lyso-ePLs to furnish PUFA-ePLs. TMEM164-null cells show substantial reductions in PUFA-ePLs, but not PUFA ester phospholipids, supporting that the selective suppression of PUFA-ePLs is sufficient to protect cells from ferroptosis and designating TMEM164 as a key enzyme specifically responsible for regulating this class of lipids.
Common neural mechanisms control attention and working memory
Authors: Zhou Ying , Curtis Clayton E. , Sreenivasan Kartik , Fougnie Daryl 
Published: July 2022

AbstractAlthough previous studies point to qualitative similarities between working memory (WM) and attention, the degree to which these two constructs rely on shared neural mechanisms remains unknown. Focusing on one such potentially shared mechanism, we tested the hypothesis that selecting an item within WM utilizes similar neural mechanisms as selecting a visible item via a shift of attention. We used fMRI and machine learning to decode both the selection among items visually available and the selection among items stored in WM in human subjects (both sexes). Patterns of activity in visual, parietal, and to a lesser extent frontal cortex predicted the locations of the selected items. Critically, these patterns were strikingly interchangeable; classifiers trained on data during attentional selection predicted selection from WM, and classifiers trained on data during selection from memory predicted attentional selection. Using models of voxel receptive fields, we visualized topographic population activity that revealed gain enhancements at the locations of the externally and internally selected items. Our results suggest that selecting among perceived items and selecting among items in WM share a common mechanism. This common mechanism, analogous to a shift of spatial attention, controls the relative gains of neural populations that encode behaviorally relevant information.Significance statementHow we allocate our attention to external stimuli that we see and to internal representations of stimuli stored in memory might rely on a common mechanism. Supporting this hypothesis, we demonstrated that not only could patterns of human brain activity predict which items were selected during perception and memory, but that these patterns were interchangeable during external and internal selection. Additionally, this generalized selection mechanism operates by changes in the gains of the neural populations both encoding attended sensory representations and storing relevant memory representations.
Re-examining age-related loyalty for low-involvement purchasing
Authors: Mecredy Philip , Wright Malcolm , Feetham Pamela , Stern Philip 
Published: July 2022

Purpose
Previous research on age-related loyalty is sparse, contradictory and suffers from methodological limitations and criticisms. This study aims to apply two methodological advances to fresh purchasing data to give a much clearer picture of age-related differences in brand loyalty.

Design/methodology/approach
An online brand choice survey (n = 1,862) is used to examine age-related loyalty within three low-involvement categories in New Zealand. The polarisation index (φ) is adopted as the measure of loyalty to control for confounding influences present in prior research. Results for chronological age are validated through comparison with results for measures of cognitive, biological and sociological age, as well as household life cycle.

Findings
Contrary to prior research, age-related differences in loyalty are detected in two of the three low-involvement categories studied. The third category does not show detectable loyalty for any age group. Although differences in brand loyalty are broadly present across all age measures, no alternative measure outperforms chronological age in detecting variations in age-related loyalty.

Research limitations/implications
To the best of the authors’ knowledge, this is the first evidence that age-related brand loyalty is present in low-involvement categories. However, effects are small and easily obscured by confounding factors. More research is needed to determine how results vary by category.

Practical implications
Despite showing minor differences in loyalty, older consumers still purchase from a wide portfolio of brands and so should not be ignored by marketers. Future research can investigate loyalty for older consumers by adopting the method of analysing differences in polarisation (φ) for chronological age groups.

Originality/value
Previous contradictory findings and methodological concerns about measurement of age-related loyalty are resolved through use of the polarisation index (φ) as a measure of loyalty and by confirmation that chronological age performs as well as any other age measure.
A collaboratory model for creation of digital language archives in India
Authors: R. Karthick Narayanan , Takhellambam Meiraba 
Published: July 2022

Purpose
This paper aims to explore a model of digital language archiving based on a collaboration between under-resourced indigenous communities and an institutional library. The model’s effectiveness is assessed in creating resources and digital language archives to support speaker communities and language documentation programmes for endangered and lesser-known languages in India.

Design/methodology/approach
The model of SiDHELA, the first indigenous language archive developed in India at Sikkim University by the Centre for Endangered Languages in collaboration with the Central Library, is described.

Findings
This study finds that localised repositories developed in collaboration with institutional libraries work as a more effective and accessible resource centre for indigenous communities, rather than the centralised data stores that collate all language data, which is the dominant method of language documentation in the world.

Social implications
It is the authors’ belief that the active role of libraries in language documentation and preservation of indigenous knowledge will open future gateways for language revitalization for under-resourced languages of the world.

Originality/value
SiDHELA is a novel attempt at localised digital language archiving in collaboration with indigenous communities of Sikkim and the North Bengal region of India.
Job security, value congruence, and work outcomes: revisiting the mediating role of work engagement
Authors: Gupta Anuj , Chakravorty Arjun , Garg Neha , Singh Pankaj 
Published: July 2022

PurposeThough the concept of work engagement has been extensively explored in the academic literature, however, with engagement levels declining globally – causing hike in undesired employee attitudes and behaviours – there is a need to revisit its antecedents and consequences that bear higher current relevance. Within the context of the Indian information technology (IT) sector, this study aims to explore the role of job security and value congruence as two critical antecedents which not only lead to increased engagement levels but also consequently yield the enhanced perception of change, amplified general life satisfaction and reduced intent to leave among employees.Design/methodology/approachData were collected from 363 software developers (SDs) in India using the survey questionnaire method and structured equation modelling was used to test the proposed measurement and structural model. The results supported the proposed hypotheses and confirmed the role of work engagement as a mediator between the studied antecedents and consequences.FindingsResults from a study of 363 SDs across India support the proposed hypotheses and confirm the role of work engagement as a mediator between the studied antecedents and consequences.Research limitations/implicationsThis study was cross-sectional; therefore, caution is necessary while making any causal inferences. Further work based on longitudinal data would strengthen these findings.Practical implicationsThe findings of the study will provide the decision-makers of IT companies with tools to increase engagement among SDs thereby increasing favorable outcomes for organizations and individual employees in the current times.Originality/valueThe study establishes job security and value congruence, as two critical yet cost-effective measures that today’s organization need to integrate into its human resources functions not just to boost employee engagement levels but also to control spiraling costs due to unintended turnover, employee’s resistance of organizational changes and employee ill-being. Future research avenues and practical implications have been discussed.
Factors influencing making a choice and accessing a hearing aid among elders with hearing disability: mixed methods
Authors: Dindamrongkul Ramida , Riewpaiboon Wachara , Yimtae Kwanchanok , Krityakiarana Warin , Niyomphol Wiraman 
Published: July 2022

Purpose
Hearing aid (HA) using is an option for enhancing the sound transmission. It effectively improves hearing ability during communication. In Thailand, two-third of hearing impaired persons were elders, while the utilization of an HA was low. This study aims to explore how the decision was made on the use of HA among the hearing impaired elderly.

Design/methodology/approach
Mixed-methods sequential explanatory design was used by starting with a retrospective study to identify the prevalence of HA use and influencing factors including demographic and clinical data. Total, 199 elders with moderate to severe hearing impairment were enrolled. Qualitative data collection for thematic analysis was conducted by interviewing 28 participants to reveal elders’ subjective reasoning.

Findings
It was found that 25.63% of elders used an HA, whereas age, types of health insurance and disability registration were significant influencing factors. Six themes of subjective reasoning emerged including social activities, disability perspective, social support, medical and personnel, rights and accessibility and benefit of HA, which determined the elders’ decisions on HA use.

Originality/value
This study broadened insights of the elders’ decision process on HA use, which was mutually made by both health-care professional and care recipients. The elders themselves would make the final decision. Not only objective indications but also subjective reasoning of users played significant roles on HA acquisition. To enhance HA use among hearing impaired elders, patient engagement in decision-making was crucial while hearing counselling and elimination of reimbursement barriers became essential.
Capabilities for enhancing supply chain resilience and responsiveness in the COVID-19 pandemic: exploring the role of improvisation, anticipation, and data analytics capabilities
Authors: Munir Manal , Jajja Muhammad Shakeel Sadiq , Chatha Kamran Ali 
Published: July 2022

PurposeThis study aims to identify critical capabilities to address unforeseen and novel disruptions, such as those instigated by COVID-19, and explore their role as essential enablers of supply chain resilience and responsiveness, leading to improved performance.Design/methodology/approachThe structural equation modeling technique was employed for analyzing the proposed associations using survey data from 206 manufacturers operating during the COVID-19 pandemic in a developing country, Pakistan.FindingsKey findings show how improvisation and anticipation act distinctly yet jointly to facilitate supply chain resilience and responsiveness during the COVID-19 pandemic. Also, data analytics capability positively affects anticipation and improvisation, which mediate the effect of data analytics on supply chain resilience and responsiveness.Research limitations/implicationsThe findings contribute to the theoretical and empirical understanding of the existing literature, suggesting that a combination of improvisation, anticipation and data analytics capabilities is highly imperative for enhancing supply chain resilience and responsiveness in novel and unexpected disruptions.Originality/valueThis is the first study to examine the impact of data analytics on improvisation and anticipation and the latter as complementary capabilities to enhance supply chain resilience and responsiveness. The empirical investigation explores the interplay among data analytics, improvisation, and anticipation capabilities for enhancing supply chain resilience, responsiveness, and performance during the unforeseen and novel disruptions, such as brought to bear by the COVID-19 pandemic.
Into the eXperience-verse: the strategic frontier of cloud business innovation and value co-creation
Authors: Ramaswamy Venkat , Narayanan Krishnan 
Published: July 2022

Purpose
The authors introduce readers to the eXperience-verse revolution, the next strategic frontier of cloud business innovation and value co-creation.

Design/methodology/approach
The eXperience-verse revolution unfolds concurrently with the evolution of the digital technologies and as enterprises learn to harness them and create greater and more unique, personalized value to all stakeholding individuals-as-experiencers.

Findings
Unlike the previous four Industrial Revolutions driven by technology, this new era requires an “experience-first” frame of reference of value creation by every enterprise.

Practical/implications
Emerging technologies are leveraged at the moment of engagement between the enterprise and the experiencers?the goal is to engender value to the individual-as-experiencer.

Originality/value
As industry clouds now accelerate strategic business innovation of interactive experience ecosystems, a whole new dimension of value-innovation and value-creation is being created - the “eXperience-verse”.