bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical Modeling of Moored Floating Platforms for Wave Energy Converters Using DualSPHysics
Authors: Tagliafierro Bonaventura , Martínez-Estévez Iván , Crego-Loureiro César , Domínguez José M. , Crespo Alejandro J. C. , Coe Ryan G. , Bacelli Giorgio , Gómez-Gesteira Moncho , Viccione Giacomo 
Published: October 2022

Abstract
The DualSPHysics open-source code establishes a comprehensive and efficient framework for simulating coastal and ocean engineering structures, which has been proven to be particularly reliable in wave energy converter (WEC) simulation. In this research, the experimental data of the floating oscillating surge wave energy converter (FOSWEC), is used for validation purposes. The FOSWEC2 device developed by SANDIA National Laboratories (US) is quite complex as it has several floating parts, anchor legs and a power take-off system (PTO) connected to the pitching motion of two flaps. Kinetic energy is in fact converted from the relative rotation between the flaps and a movable frame of the platform, setting a significant challenge for the validation of the FOSWEC with time-domain integrated methods. This work proposes a first validation campaign carried out using regular waves, and considering different parameters for the definition of the PTO system. The numerical model prediction for the platform motion (surge and pitch) and the relative flap pitch angle (bow and aft) shows that the model is able to deal with multi-body dynamics interacting with wave-induced forces.
Numerical Investigation on Scale Effect of 5415M Maneuverability
Authors: Zhang Donglei , Wang Qing , Dong Kai , Wang Xianzhou 
Published: October 2022

Abstract
A numerical investigation about the effect of ship model scale on turning maneuver has been presented in this study. A preliminary US Navy surface combatant, David Taylor Model Basin (DTMB) 5415M, is chosen as the object of study. An in-house computational fluid dynamics (CFD) solver is used for the numerical simulation. Structured grid has been divided for the model and the use of overset grid technology allows the deflection of the rudders when the surface combatant undergoes 6 degrees of freedom motions. Numerical modelling errors for the simulation of steady turning at 35-degree deflection of DTMB 5415M rudder at Fr = 0.41 in calm water have been estimated. The grid convergence studies have been conducted for the uncertainty analysis and the numerical results have been compared with the existed experimental data, which showed a good agreement. Three different scales (1:5, 1:15, 1:35.48) have been selected for the investigation to study the scale effects on ship turning maneuvers. Ship motions, hydrodynamic forces and moments for all the scales have been compared for the purpose of analyzing the scale effects on ship maneuverability. The results show that larger scale has smaller tactical diameter and smaller roll angle. The results of intermediate scale are less than 5% compared with the smallest scale, and the difference between the largest scale and the smallest scale is more than 10%, especially the roll angle reaches 50%. The scales have different influence on forces coefficient and moment coefficient of different directions.
Platform Motion Forecast of Hywind Floating Offshore Wind Turbine Based on SADA Method and Full-Scale Measurement Data
Authors: Chen Peng , Hu Zhiqiang 
Published: October 2022

Abstract
The dynamic responses analysis of floating offshore wind turbines (FOWTs) is very complex, which involves very strong nonlinear and coupling effects. This has also led to the current engineering application of FOWTs still facing critical gaps, especially in innovative design and dynamic performances prediction. Both academia and the wind industry are constantly exploring breakthroughs in terms of design and maintenance for FOWTs. The purpose of this paper is to apply a novel method, named SADA, which combines AI technology with numerical analysis methods, on full-scale measured data to optimize the platform motion prediction of the Hywind FOWT. The full-scale data used in this paper was collected by one of Hywind FOWTs in Scotland. The results show that the AI-trained numerical model can predict the motions of Hywind supporting floater with higher accuracy. The tension of the fairlead has undergone a huge change although the deformation of the blades and the tower has been reduced. In addition, compared with the deformation of the tower and the blades, the changes in the mooring system are the most significant. In summary, the SADA method can bring an innovative vision for FOWTs’ full-scale measurement technology in the future.
Dynamic Response Analysis of a Novel Semi-Submersible Floating Offshore Wind Turbine Based on Different Mooring System Designs
Authors: Zhao Zhixin , Wang Wenhua , Shi Wei , Li Xin , Wang Bin 
Published: October 2022

Abstract
A conceptual semi-submersible platform at the water depth of 100 m is proposed to support the Technical University of Denmark (DTU) 10 MW wind turbine and four types of mooring systems are designed to constrain the motions of this newly designed semi-submersible platform. The fully coupled time domain simulation is conducted using aero-hydro-servo-elastic OpenFAST code and the dynamic responses of the floating wind turbine concept are studied based on different mooring system designs. This innovative concept meets reasonable natural period requirements and achieves great stability under design environmental conditions. Furthermore, the difference of the four types of mooring systems on the motion responses and structural dynamics of the 10 MW semi-submersible floating offshore wind turbine (FOWT) is investigated and compared, and the optimal mooring system design is suggested.
Data Fusion for Jack-Up Wind Load Prediction
Authors: Xing Xiuqing , Dao My Ha , Zhang Baili , Lou Jing , Tan Wei Siang , Cui Yongdong , Khoo Boo Cheong 
Published: October 2022

Abstract
In this study, wind load on a typical jack-up is calculated through CFD simulation and measured through wind tunnel tests for operational condition (OC) and extreme condition (EC). The Reduced Order Method (ROM) model is built up based on high fidelity CFD simulation results. Two data assimilation models, ROM-based Gappy POD and Extended Kalman Filter (EKF) model, are developed to fuse the measured data from wind tunnel tests with the numerical results for jack-up wind load predictions. The outcomes show that both the EKF and gappy POD are able to predict the wind loads on the jack-up platform under OC and EC with satisfying accuracy, even with only 21 measurement data. The findings of this study provide an option for fusing the numerical simulation results with wind-tunnel measurements or operational data for accurately predicting the wind load on marine vessels and offshore platforms.
The Percentage of Mature Height as a Morphometric Index of Somatic Growth: A Formal Scrutiny of Conventional Simple Ratio Scaling Assumptions
Authors: Lolli Lorenzo , Johnson Amanda , Monaco Mauricio , Di Salvo Valter , Atkinson Greg , Gregson Warren 
Published: October 2022

Purpose: To assess conventional assumptions that underpin the percentage of mature height index as the simple ratio of screening height (numerator) divided by actual or predicted adult height (denominator). Methods: We examined cross-sectional data from 99 academy youth soccer players (chronological age range, 11.5 to 17.7 y) skeletally immature at the screening time and with adult height measurements available at follow-up. Results: The y-intercept value of −60 cm (95% confidence interval, −115 to −6 cm) from linear regression between screening height and adult height indicated the failure to meet the zero y-intercept assumption. The correlation coefficient between present height and adult height of .64 (95% confidence interval, .50 to .74) was not equal to the ratio of coefficient of variations between these variables (CVx/CVy = 0.46) suggesting Tanner’s special circumstance was violated. The non-zero correlation between the ratio and the denominator of .21 (95% confidence interval, .01 to .39) indicated that the percentage of mature height was biased low for players with generally shorter adult height, and vice versa. Conclusion: For the first time, we have demonstrated that the percentage of mature height is an inconsistent statistic for determining the extent of completed growth, leading to potentially biased inferences for research and applied purposes.
Exploring the intensity, barriers and correlates of physical activity In Iranian pregnant women: a cross-sectional study
Authors: Ahmadi Katayon , Amiri-Farahani Leila , Haghani Shima , Hasanpoor‑Azghady Seyedeh Batool , Pezaro Sally 
Published: October 2022

ObjectivesTo determine the intensity, barriers and correlates of physical activity (PA) in Iranian pregnant women.MethodsThis cross-sectional study was carried out with 300 eligible pregnant women referred to the Ilam health centres and bases using stratified random sampling with proportional allocation. Data collection tools included a demographic and obstetrical history questionnaire, the Pregnancy Physical Activity Questionnaire and the Exercise Benefits/Barriers Scale. The association between demographic and obstetrical characteristics and PA intensity and barriers were studied using multiple linear regression models.ResultsThe mean and SD of the total score of PA intensity were 47.15 and 26.25 metabolic equivalent of task (MET)-hour/week, respectively. The highest and the lowest barriers were related to the time expenditure (42.77±18.04) and family discouragement (50.72±24.99) constructs, respectively. The PA intensity was significantly associated with prepregnancy or early pregnancy body mass index (B=25.6), ethnicity (B=16.94), level of education (B=−8.77), number of children (B=5.95), gestational age (B=0.81), participation in childbirth preparation classes (B=−11.27), habitual exercise before pregnancy (B=6.09), income (B=−9.22). The PA barriers were significantly associated with ethnicity (B=−4.96), income (B=2.23) and habitual exercise before pregnancy (B =−1.35).ConclusionPA intensity may be enhanced by encouraging individuals to be more physically active before pregnancy. Additionally, strategies to enhance support from friends and family to engage in PA throughout pregnancy and PA interventions focused on women with lower levels of income and education are required.
Urban–rural disparities in mild cognitive impairment and its functional subtypes among community-dwelling older residents in central China
Authors: Liu Dan , Li Lin , An Lina , Cheng Guirong , Chen Cong , Zou Mingjun , Zhang Bo , Gan Xuguang , Xu Lang , Ou Yangming , Wu Qingming , Wang Ru , Zeng Yan 
Published: October 2022

BackgroundSubstantial variations in the prevalence of mild cognitive impairment (MCI) and its subtypes have been reported, although mostly in geographically defined developed countries and regions. Less is known about MCI and its subtypes in rural areas of less developed central China.AimsThe study aimed to compare the prevalence of MCI and its subtypes in residents aged 65 years or older in urban and rural areas of Hubei Province, China.MethodsParticipants aged 65 years or older were recruited between 2018 and 2019. Inperson structured interviews and clinical and neuropsychological assessments were performed at city health community centres and township hospitals.ResultsAmong 2644 participants without dementia, 735 had MCI, resulting in a prevalence of 27.8% for total MCI, 20.9% for amnestic MCI (aMCI) and 6.9% for non-amnestic MCI (naMCI). The prevalence of MCI in urban and rural areas was 20.2% and 44.1%, respectively. After adjusting for demographic factors, the prevalence of total MCI, aMCI and naMCI differed significantly between rural and urban areas (adjusted odds ratio (OR) 2.10, 1.44 and 3.76, respectively). Subgroup analysis revealed an association between rural socioeconomic and lifestyle disadvantage and MCI and its subtypes.ConclusionsOur findings suggest that the prevalence of MCI among urban residents in central China is consistent with that in other metropolis areas, such as Shanghai, but the prevalence in rural areas is twice that in urban areas. Prospective studies and dementia prevention in China should focus on rural areas.
Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy
Authors: He Huan , Liao Qibin , Zhao Chen , Zhu Cuisong , Feng Meiqi , Liu Zhuoqun , Jiang Lang , Zhang Linxia , Ding Xiangqing , Yuan Min , Zhang Xiaoyan , Xu Jianqing 
Published: October 2022

BackgroundHypoxia is a striking feature of most solid tumors and could be used to discriminate tumors from normoxic tissues. Therefore, the design of hypoxia-conditioned Chimeric Antigen Receptor (CAR) T cells is a promising strategy to reduce on-target off-tumor toxicity in adoptive cell therapy. However, existing hypoxia-conditioned CAR-T designs have been only partially successful in enhancing safety profile but accompanied with reduced cytotoxic efficacy. Our goal is to further improve safety profile with retained excellent antitumor efficacy.MethodsIn this study, we designed and constructed a hypoxia-inducible transcription amplification system (HiTA-system) to control the expression of CAR in T (HiTA-CAR-T) cells. CAR expression was determined by Flow cytometry, and the activation and cytotoxicity of HiTA-CAR-T cells in vitro were evaluated in response to antigenic stimulations under hypoxic or normoxic conditions. The safety of HiTA-CAR-T cells was profiled in a mouse model for its on-target toxicity to normal liver and other tissues, and antitumor efficacy in vivo was monitored in murine xenograft models.ResultsOur results showed that HiTA-CAR-T cells are highly restricted to hypoxia for their CAR expression, activation and cytotoxicity to tumor cells in vitro. In a mouse model in vivo, HiTA-CAR-T cells targeting Her2 antigen showed undetectable CAR expression in all different normoxic tissues including human Her2-expresing liver, accordingly, no liver and systemic toxicity were observed; In contrast, regular CAR-T cells targeting Her2 displayed significant toxicity on human Her2-expression liver. Importantly, HiTA-CAR-T cells were able to achieve signiﬁcant tumor suppression in murine xenograft models.ConclusionOur HiTA system showed a remarkable improvement in hypoxia-restricted transgene expression in comparison with currently available systems. HiTA-CAR-T cells presented significant antitumor activities in absence of any significant liver or systemic toxicity in vivo. This approach could be also applied to design CAR-T cell targeting other tumor antigens.
High-precision mass measurement of doubly magic $$^{208}$$Pb
Authors: Kromer Kathrin , Lyu Chunhai , Door Menno , Filianin Pavel , Harman Zoltán , Herkenhoff Jost , Huang Wenjia , Keitel Christoph H. , Lange Daniel , Novikov Yuri N. , Schweiger Christoph , Eliseev Sergey , Blaum Klaus 
Published: October 2022

AbstractThe absolute atomic mass of $$^{208}$$

208

Pb has been determined with a fractional uncertainty of $$7\times 10^{-11}$$

7
×

10

-
11

by measuring the cyclotron-frequency ratio R of $$^{208}$$

208

Pb$$^{41+}$$

41
+

to $$^{132}$$

132

Xe$$^{26+}$$

26
+

with the high-precision Penning-trap mass spectrometer Pentatrap and computing the binding energies $$E_{\text {Pb}}$$

E
Pb

and $$E_{\text {Xe}}$$

E
Xe

of the missing 41 and 26 atomic electrons, respectively, with the ab initio fully relativistic multi-configuration Dirac–Hartree–Fock (MCDHF) method. R has been measured with a relative precision of $$9\times 10^{-12}$$

9
×

10

-
12

. $$E_{\text {Pb}}$$

E
Pb

and $$E_{\text {Xe}}$$

E
Xe

have been computed with an uncertainty of 9.1 eV and 2.1 eV, respectively, yielding $$207.976\,650\,571(14)$$

207.976

650

571
(
14
)

u ($$\text {u}=9.314\,941\,024\,2(28)\times 10^{8}$$

u
=
9.314

941

024

2

(
28
)

×

10
8

eV/c$$^2$$

2

) for the $$^{208}$$

208

Pb neutral atomic mass. This result agrees within $$1.2\sigma $$

1.2
σ

with that from the Atomic-Mass Evaluation (AME) 2020, while improving the precision by almost two orders of magnitude. The new mass value directly improves the mass precision of 14 nuclides in the region of Z = 81–84 and is the most precise mass value with $$A>200$$

A
>
200

. Thus, the measurement establishes a new region of reference mass values which can be used e.g. for precision mass determination of transuranium nuclides, including the superheavies.
Synchronization in a network of map-based neurons with memristive synapse
Authors: Wang Zhen , Tian Huaigu , Krejcar Ondrej , Namazi Hamidreza 
Published: October 2022

AbstractThe synchronization of coupled neurons has been an important field of study in neuroscience. In this paper, the synchronization in coupled map-based neurons is studied. It is assumed that the neurons are coupled via a memristor. Firstly, the case of two-coupled neurons is investigated, and then two neurons are used as the units of a ring network. It is shown that the memristive coupling coefficient and the initial condition of the flux variable affect the synchronization of two neurons. By increasing the memristive coupling coefficient, multiple synchronous and asynchronous regions are observed. In the ring network, two neurons in each unit can become synchronous, but the whole network does not reach complete synchronization.
An Extragastrointestinal Tumor Diagnosed as a Vaginal Mass during Pregnancy
Authors: Ando Reo , Taniguchi Shuichi , Arita Shuji , Aman Murasaki , Marutsuka Kousuke , Shimamoto Tomihiro 
Published: October 2022

We report a case of an extragastrointestinal stromal tumor diagnosed as a vaginal mass during pregnancy. The mass was detected during routine examination at 24 weeks of gestation. At 26 weeks, the patient underwent transvaginal ultrasonography and magnetic resonance imaging, which revealed a blood flow-rich mass of approximately

50
×
30

mm

in the rectovaginal septum. At 29 weeks of gestation, we resected the mass vaginally and the pathological diagnosis was a gastrointestinal stromal tumor. Chemotherapy was withheld until after full-term birth because the proliferation index of the tumor cells was low. The patient delivered a healthy infant. Imatinib was commenced at 1 month postpartum, with no recurrence or metastasis after 2.5 years. An extragastrointestinal stromal tumor as a vaginal mass in pregnancy has not been reported; however, our case suggests that the tumor should be considered a differential diagnosis of a vaginal mass in pregnancy.
Pharmacological Landscape of FDA-Approved Anticancer Drugs Reveals Sensitivities to Ixabepilone, Romidepsin, Omacetaxine, and Carfilzomib in Aggressive Meningiomas
Authors: Jungwirth Gerhard , Yu Tao , Liu Fang , Cao Junguo , Alaa Eddine Montadar , Moustafa Mahmoud , Abdollahi Amir , Warta Rolf , Unterberg Andreas , Herold-Mende Christel 
Published: October 2022

Abstract

Purpose:
To date, there are no systemic treatment options for patients with recurrent or refractory meningioma.

Experimental Design:
To identify effective drugs, we performed a large-scale drug screening using FDA-approved drugs on several meningioma cell lines. The impact of the top four compounds was assessed on cell viability, proliferation, colony formation, migration, and apoptosis. In addition, the antineoplastic effects of the selected drugs were validated in a heterotopic xenograft mouse model.

Results:
Analyses of the viability of meningioma cells treated with 119 antineoplastic FDA-approved drugs resulted in categorization into sensitive and resistant drug–response groups based on the mean IC50 values and peak serum concentrations (Cmax) in patients. Eighty drugs, including 15 alkylating agents, 14 antimetabolites, and 13 tyrosine kinase inhibitors, were classified as resistant (IC50 &gt; Cmax). The sensitive drug–response group (n = 29, IC50 &lt; Cmax) included RNA/protein synthesis inhibitors, proteasome inhibitors, topoisomerase, tyrosine-kinase, and partial histone deacetylase and microtubule inhibitors. The IC50 value of the four most effective compounds (carfilzomib, omacetaxine, ixabepilone, and romidepsin) ranged from 0.12 to 9.5 nmol/L. Most of them caused cell-cycle arrest in the G2–M-phase and induced apoptosis. Furthermore, all drugs except romidepsin significantly inhibited tumor growth in vivo. The strongest antineoplastic effect was observed for ixabepilone, which reduced tumor volume by 86%.

Conclusions:
In summary, a large-scale drug screening provides a comprehensive insight into the anti-meningioma activities of FDA-approved drugs, and identified carfilzomib, omacetaxine, ixabepilone, and romidepsin as novel potent antineoplastic agents for the treatment of aggressive meningiomas. The most pronounced effects were observed with ixabepilone mandating for further clinical investigation.
Real-time wireless temperature measurement system of infant incubator
Authors: Sukma Irawan , Ardiatna Wuwus , Novitasari Novitasari , Permatasari Vera , Hidayat Siddiq Wahyu , Hidayat Asep Rahmat , Khotimah Khusnul , Supono Ihsan 
Published: October 2022

The internet of things (IoT) has allowed for ubiquitous measurement. Infant incubator temperature is one of crucial parts that need to be measured, especially for the stability and uniformity temperature. Based on the interpretation of IEC 60601-2-19, we proposed measurement method using IoT with the message queue telemetry transport (MQTT). In the 10,000 packet, the result shows the quality of service (QoS) level 2 of the system has the highest delay, however it has the lowest packet loss data than the other QoS. For 1 hour, the uniformity result and stability can fulfill the standards. Uniformity of 32°C, the lowest difference is point C with 0.32 °C, and the highest difference is point B with 0.75 °C. Uniformity of 36 °C, the lowest difference is point B with 0.27 °C, and the highest difference is point C with 0.79 °C. The stability of 32 °C and 36 °C is 0.32 °C and 0.44 °C, respectively. Moreover, the Kruskal Wallis test shows the highest difference average from point M is point A and B. It occurred because of the point A and B located far from the heater part, so the point A and B colder than point C.
Methodology for determining the parameters of high-temperature superconducting power transformers with current limiting function
Authors: Manusov Vadim Zinovievich , Ivanov Dmitriy Mihailovich , Semenov Arseniy Valerievich , Ivanov Gennady Viktorovich 
Published: October 2022

<span lang="EN-US">This paper substantiates a new adaptive method for determining parameters of high-temperature superconducting power transformers with current limiting function. The main focus is the design of current-limiting superconducting windings in the light of new restrictions on current density, magnetic induction, critical current and critical temperature. The presented method considers the nature of alternating current (AC) losses in a superconductor under nominal operating conditions, features of the dielectric medium (liquid nitrogen), as well as the reduced values of the short-circuit voltage (0.5 to 1.5%). The main design features of high-temperature superconducting (HTS) transformers are specified, and a prototype of a three-phase HTS transformer of 63 kVA with a short-circuit current limiting function is developed. It is shown that HTS units have some advantages over conventional transformers: a 90 to 95% active losses reduction, short-circuit current limitation function, explosion and fire safety, a 60% reduction in weight and size, and increased efficiency (up to 99.8%). Experimental studies confirm that the short-circuit current limitation function is safe and efficient. It is demonstrated that during the short-circuit current limitation, significant heat flows occur on the windings, which should not exceed the critical value above which the superconductor could not return to the superconducting state by itself.</span>