bluuebunny/crossref_metadata_2025_split huggingface dataset:
Common procedures of remote measurement-based care in an integrated behavioural health context: protocol for a scoping review
Authors: Richardson Eric , Hogan Timothy P , Shimada Stephanie L , Sliwinski Samantha K , Kim Bo 
Published: September 2022

IntroductionIntegrated behavioural health, a model of care that embeds mental health services in primary care, can potentially increase access to mental healthcare. With the increase in health information technologies, remote measurement-based care (RMBC) presents an opportunity to improve support of integrated care. This scoping review will comprehensively examine what common procedures are followed when RMBC for mental health is tested in integrated care settings.Methods and analysisBased on an established six-step framework for conducting scoping reviews, we will search PubMed, Embase, PsycINFO, Cochrane, EBSCOhost and Web of Science with search terms related to ‘integrated care’ and ‘RMBC’. Articles published from 2015 onwards, in English, including an intervention that meets our definition of RMBC, and are conducted in collaboration with primary care or in a primary care setting will be included. After data extraction, we will categorise key findings along the following dimensions: (1) common delivery practices of RMBC; (2) common technologies and instruments used and (3) most common barriers and facilitators when implementing RMBC in an integrated care model.Ethics and disseminationEthics approval is not required for this scoping review. For maximum impact, we will disseminate the findings to the scientific community (via publication in a peer-reviewed journal and at national conferences) and to the broader healthcare community. We will share findings with the broader healthcare community through our research centre’s existing stakeholder communication structures and through guidance from our multidisciplinary research team. These key stakeholder relationships will continue to guide our subsequent RMBC research following the review.
Factors affecting the occurrence of otitis media with effusion in preschool and elementary school children: a comparative cross-sectional study
Authors: Restuti Ratna Dwi , Tamin Susyana , Nugroho Dwi Agustawan , Hutauruk Syahrial Marsinta , Mansyur Muchtaruddin 
Published: September 2022

ObjectiveIdentify the risk factors for otitis media with effusion (OME), especially laryngopharyngeal reflux (LPR), adenoid hypertrophy and allergic rhinitis, that could be used to develop prevention strategies in children.DesignA comparative cross-sectional study was conducted to make sure the adequacy of proportions of OME and non-OME cases in finding the related factors.SettingHistory taking, ear/nose/throat (ENT) examination, and tympanometry were performed in preschool and elementary schools. Flexible fibreoptic nasopharyngolaryngoscopy was performed in a bronchoesophagology outpatient clinic in a tertiary referral hospital in Jakarta, Indonesia.ParticipantsPreschool and elementary children in East Jakarta, Indonesia were recruited for this study. A total of 2016 participants underwent history taking, ENT examination and tympanometry. The case group was 46 children with OME, and the control group was 46 children without OME. The number of subjects fulfilled the minimum sample size for two proportions comparison.Main outcome measuresA type B tympanogram indicated OME. A Reflux Finding Score of more than 7 indicated LPR. Adenoid hypertrophy was diagnosed using flexible fibreoptic nasopharyngolaryngoscopy. Allergic rhinitis was diagnosed using a questionnaire based on the International Study of Asthma and Allergies in Childhood phase III that has been validated for Indonesians.ResultsThe proportion of LPR in the OME group was significantly higher than in the non-OME group, at 78.3% and 52.2%. The probability of OME occurrence in patients with LPR was 3.3 times higher than in patients without LPR (OR 3.3; 95% CI 1.33 to 8.189; p=0.01). There was no significant relationship between adenoid hypertrophy and OME (p=0.211; 95% CI 0.71 to 3.97), and also between allergic rhinitis and OME (p=0.463; 95% CI 0.61 to 4.28).ConclusionThe probability of OME occurrence in patients with LPR was 3.3 times higher than in patients without LPR. LPR should be considered in patients with OME and vice versa.
Early experiences of the Your COVID Recovery®digital programme for individuals with long COVID
Authors: Lloyd-Evans Phoebe H I , Baldwin Molly M , Daynes Enya , Hong Annabel , Mills George , Goddard Amye C N , Chaplin Emma , Gardiner Nikki , Singh Sally J 
Published: September 2022

ObjectivesTo describe the early data from the Your COVID Recovery®digital programme and to explore the data collected from two embedded outcome measures.DesignObservational.SettingPrimary and secondary care (England—Online).Participants110 individuals completed the programme (68.1% female, 88.1% White British, age: 46.3 (10.8) years, weight: 86.5 (21.1) kg, height: 169.3 (10.0) cm). 47.2% of patients reported comorbidities.InterventionFollowing an assessment by a healthcare professional, individuals with long COVID were offered access to the Your COVID Recovery®digital programme. The programme comprises of four stages for the participants to progress through. Participants are encouraged to record severity of their symptoms and amount of activity they are doing on a symptom and an activity tracker. Resources and interactive material on managing symptoms of long COVID are available throughout each stage.Primary outcome measuresQuestionnaire (EuroQ0l 5-Dimension 5-Level (EQ-5D-5L) and the chronic obstructive pulmonary disease assessment test (CAT)) data were extracted from the site from 11 March 2021 until 9 November 2021.ResultsParticipants were on the programme for 8.6 (4.3) weeks. There was a statistically significant increase in EQ-5D-5L visual analogue scale (VAS) score (pre=48.8 (19.5); post=59.9 (22.1); p<0.01). The EQ-5D-5L Index Value preintervention to postintervention did improve but not significantly (pre=0.5 (0.3); post=0.6 (0.3); p=0.09). CAT total score improved significantly preintervention to postintervention (pre=19.8 (7.2); post=15.6 (7.6); p<0.01). All CAT item scores significantly improved preintervention to postintervention (p<0.005), except the phlegm item score (p=0.168).DiscussionThis early data describes the impact of the Your COVID Recovery®digital programme on the first cohort of patients to complete the digital recovery programme. The outcome data are promising and should encourage uptake.
Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers
Authors: Kaneko Kensuke , Acharya Chaitanya R , Nagata Hiroshi , Yang Xiao , Hartman Zachary Conrad , Hobeika Amy , Hughes Philip F , Haystead Timothy A J , Morse Michael A , Lyerly Herbert Kim , Osada Takuya 
Published: September 2022

BackgroundWe previously demonstrated potent antitumor activity against human breast cancer xenografts using photodynamic therapy (PDT) targeting a novel tumor-specific photosensitizer (HS201), which binds heat shock protein 90 (HS201-PDT). However, induction of systemic antitumor immunity by HS201-PDT alone or by the combination strategy with immune checkpoint blockade has yet to be determined.MethodsUsing unilateral and bilateral implantation models of syngeneic breast tumors (E0771, MM3MG-HER2, and JC-HER3) in mice, we assessed whether HS201-PDT could induce local and systemic antitumor immunity. In an attempt to achieve a stronger abscopal effect for distant tumors, the combination strategy with anti-PD-L1 antibody was tested. Tumor-infiltrating leukocytes were analyzed by single cell RNA-sequencing and receptor-ligand interactome analysis to characterize in more detailed the mechanisms of action of the treatment and key signaling pathways involved.ResultsHS201-PDT demonstrated greater tumor control and survival in immune competent mice than in immunocompromised mice, suggesting the role of induced antitumor immunity; however, survival was modest and an abscopal effect on distant implanted tumor was weak. A combination of HS201-PDT with anti-PD-L1 antibody demonstrated the greatest antigen-specific immune response, tumor growth suppression, prolonged mouse survival time and abscopal effect. The most significant increase of intratumoral, activated CD8+T cells and decrease of exhausted CD8+T cells occurred following combination treatment compared with HS201-PDT monotherapy. Receptor-ligand interactome analysis showed marked enhancement of several pathways, such as CXCL, GALECTIN, GITRL, PECAM1 and NOTCH, associated with CD8+T cell activation in the combination group. Notably, the expression of the CXCR3 gene signature was the highest in the combination group, possibly explaining the enhanced tumor infiltration by T cells.ConclusionsThe increased antitumor activity and upregulated CXCR3 gene signature induced by the combination of anti-PD-L1 antibody with HS201-PDT warrants the clinical testing of HS201-PDT combined with PD-1/PD-L1 blockade in patients with breast cancer, and the use of the CXCR3 gene signature as a biomarker.
Heterogeneity on long-term disability trajectories in patients with secondary progressive MS: a latent class analysis from Big MS Data network
Authors: Signori Alessio , Lorscheider Johannes , Vukusic Sandra , Trojano Maria , Iaffaldano Pietro , Hillert Jan , Hyde Robert , Pellegrini Fabio , Magyari Melinda , Koch-Henriksen Nils , Sørensen Per Soelberg , Spelman Tim , van der Walt Anneke , Horakova Dana , Havrdova Eva , Girard Marc , Eichau Sara , Grand'Maison Francois , Gerlach Oliver , Terzi Murat , Ozakbas Serkan , Skibina Olga , Van Pesch Vincent , Sa Maria Jose , Prevost Julie , Alroughani Raed , McCombe Pamela A , Gouider Riadh , Mrabet Saloua , Castillo-Trivino Tamara , Zhu Chao , de Gans Koen , Sánchez-Menoyo José Luis , Yamout Bassem , Khoury Samia , Sormani Maria Pia , Kalincik Tomas , Butzkueven Helmut 
Published: September 2022

BackgroundOver the decades, several natural history studies on patients with primary (PPMS) or secondary progressive multiple sclerosis (SPMS) were reported from international registries. In PPMS, a consistent heterogeneity on long-term disability trajectories was demonstrated. The aim of this study was to identify subgroups of patients with SPMS with similar longitudinal trajectories of disability over time.MethodsAll patients with MS collected within Big MS registries who received an SPMS diagnosis from physicians (cohort 1) or satisfied the Lorscheider criteria (cohort 2) were considered. Longitudinal Expanded Disability Status Scale (EDSS) scores were modelled by a latent class growth analysis (LCGA), using a non-linear function of time from the first EDSS visit in the range 3–4.ResultsA total of 3613 patients with SPMS were included in the cohort 1. LCGA detected three different subgroups of patients with a mild (n=1297; 35.9%), a moderate (n=1936; 53.6%) and a severe (n=380; 10.5%) disability trajectory. Median time to EDSS 6 was 12.1, 5.0 and 1.7 years, for the three groups, respectively; the probability to reach EDSS 6 at 8 years was 14.4%, 78.4% and 98.3%, respectively. Similar results were found among 7613 patients satisfying the Lorscheider criteria.ConclusionsContrary to previous interpretations, patients with SPMS progress at greatly different rates. Our identification of distinct trajectories can guide better patient selection in future phase 3 SPMS clinical trials. Additionally, distinct trajectories could reflect heterogeneous pathological mechanisms of progression.
Public interest in medical assistance in dying and palliative care
Authors: Cheng Emily YiQin , Mah Kenneth , Al-Awamer Ahmed , Pope Ashley , Swami Nadia , Wong Joanne L , Mathews Jean , Howell Doris , Hannon Breffni , Rodin Gary , Shapiro Gilla K , Li Madeline , Le Lisa W , Zimmermann Camilla 
Published: September 2022

ObjectivesMedical assistance in dying (MAiD) is legal in an increasing number of countries, but there are concerns that its availability may compromise access to palliative care. We assessed public interest in MAiD, palliative care, both, or neither, and examined characteristics associated with this interest.MethodsWe surveyed a representative sample of the adult Canadian public, accessed through a panel from May to June 2019. Weighted generalised multinomial logistic regression analyses were used to determine characteristics associated with interest in referral to palliative care, MAiD, or both, in the event of diagnosis with a serious illness.ResultsOf 1362 participants who had heard of palliative care, 611 (44.8% weighted (95% CI 42.1% to 47.5%)) would be interested in both MAiD and palliative care, 322 (23.9% (95% CI 21.5% to 26.2%)) palliative care alone, 171 (12.3% (95% CI 10.5% to 14.1%)) MAiD alone and 258 (19.0% (95% CI 16.9% to 21.2%)) neither. In weighted multinomial logistic regression analyses, interest in both MAiD and palliative care (compared with neither) was associated with better knowledge of the definition of palliative care, older age, female gender, higher education and less religiosity; interest in palliative care alone was associated with better knowledge of the definition of palliative care, older age, female gender and being married/common law; interest in MAiD alone was associated with less religiosity (all p<0.05).ConclusionsThere is substantial public interest in potential referral to both MAiD and palliative care. Simultaneous availability of palliative care should be ensured in jurisdictions where MAiD is legal, and education about palliative care should be a public health priority.
Deep white matter hyperintensity is spatially correlated to MRI-visible perivascular spaces in cerebral small vessel disease on 7 Tesla MRI
Authors: Huo Yajing , Wang Yilin , Guo Cen , Liu Qianyun , Shan Lili , Liu Mingyuan , Wu Haibo , Li Guanwu , Lv Huihui , Lu Lingdan , Zhou Yintin , Feng Jianfeng , Han Yan 
Published: September 2022

BackgroundThe association between perivascular space (PVS) and white matter hyperintensity (WMH) has been unclear. Normal-appearing white matter (NAWM) around WMH is also found correlated with the development of focal WMH. This study aims to investigate the topological connections among PVS, deep WMH (dWMH) and NAWM around WMH using 7 Tesla (7T) MRI.MethodsThirty-two patients with non-confluent WMHs and 16 subjects without WMHs were recruited from our department and clinic. We compared the PVS burden between patients with and without WMHs using a 5-point scale. Then, the dilatation and the number of PVS within a radius of 1 cm around each dWMH were compared with those of a reference site (without WMH) in the contralateral hemisphere. In this study, we define NAWM as an area within the radius of 1 cm around each dWMH. Furthermore, we assessed the spatial relationship between dWMH and PVS.ResultsHigher PVS scores in the centrum semiovale were found in patients with >5 dWMHs (median 3) than subjects without dWMH (median 2, p = 0.014). We found there was a greater dilatation and a higher number of PVS in NAWM around dWMH than at the reference sites (p<0.001, p<0.001). In addition, 79.59% of the dWMHs were spatially connected with PVS.ConclusiondWMH, NAWM surrounding WMH and MRI-visible PVS are spatially correlated in the early stage of cerebral small vessel disease. Future study of WMH and NAWM should not overlook MRI-visible PVS.
Prospects for a flavour violating $$Z^\prime $$ explanation of $$\Delta a_{\mu ,e}$$
Authors: Kriewald J. , Orloff J. , Pinsard E. , Teixeira A. M. 
Published: September 2022

AbstractThe apparent tensions emerging from the comparison of experimental data of the anomalous magnetic moments of the muon and electron to the Standard Model predictions ($$\Delta a_{\mu ,e}$$

Δ

a

μ
,
e

) could be interpreted as a potential signal of New Physics. Models encompassing a light vector boson have been known to offer a satisfactory explanation to $$\Delta a_{\mu }$$

Δ

a
μ

, albeit subject to stringent experimental constraints. Here we explore a minimal extension of the Standard Model via a leptophilic vector boson $$Z^\prime $$

Z
′

, under the hypothesis of strictly flavour-violating couplings of the latter to leptons. The most constraining observables to this ad-hoc construction emerge from lepton flavour universality violation (in Z and $$\tau $$
τ
decays) and from rare charged lepton flavour violating transitions. Once these are accommodated, one can saturate the tensions in $$\Delta a_{\mu }$$

Δ

a
μ

, but $$\Delta a_{e}$$

Δ

a
e

is predicted to be Standard Model-like. We infer prospects for several observables, including leptonic Z decays and several charged lepton flavour violating processes. We also discuss potential signatures of the considered $$Z^\prime $$

Z
′

at a future muon collider, emphasising the role of the $$\mu ^+\mu ^- \rightarrow \tau ^+\tau ^- $$

μ
+

μ
-

→

τ
+

τ
-

forward-backward asymmetry as a key probe of the model.
Effect of large light-heavy neutrino mixing and natural type-II seesaw dominance to lepton flavor violation and neutrinoless double beta decay
Authors: Dash Nitali , Patra Sudhanwa , Pritimita Prativa , Yajnik Urjit A. 
Published: September 2022

AbstractWe derive the lower bound on absolute scale of lightest neutrino mass for normal hierarchy and inverted hierarchy pattern of light neutrinos by studying the new physics contributions to charged lepton flavour violations in the framework of a TeV scale left–right symmetric model. In the model the fermion sector comprises of the usual quarks and leptons plus a fermion singlet per generation and the scalar sector consists of isospin doublets, triplets and a bidoublet. The framework allows large light-heavy neutrino mixing where the light neutrino mass formula is governed by natural type-II seesaw mechanism unlike the generic type-II seesaw dominance which assumes suppressed light-heavy neutrino mixing. We demonstrate how sizeable loop-induced contribution to light neutrino mass is kept under control such that light neutrino mass formula is dominantly explained by type-II seesaw mechanism. We examine the heavy neutrino contributions with large light-heavy neutrino mixing to charged lepton flavour violating processes like $$\mu \rightarrow e \gamma $$

μ
→
e
γ

, $$\mu \rightarrow 3 e$$

μ
→
3
e

and $$\mu \rightarrow e$$

μ
→
e

conversion inside a nuclei. We present a complementary study between neutrinoless double beta decay and charged lepton flavour violation taking into account single beta decay bound, double beta decay bound and cosmology bounds on neutrino mass sum.
South and East African fracture zones: a long lifespan since the breakup of Gondwana
Authors: Roche V. , Ringenbach J.-C. , Sapin F. , Leroy S. 
Published: September 2022

Abstract

Gondwana started to split up during the Early Jurassic (
c.
180 Ma) with the separation of Antarctica and Madagascar from Africa, followed by the separation of South America and Africa during the Early Cretaceous. Thanks to recent seismic profiles, the architecture of rifted margins and the transform fault zones, which developed as a result of the relative motion between tectonic plates, have been recently evidenced and studied along the whole eastern and southeastern Africa margins (i.e. in the Western Somali Basin, the Mozambique Basin, the Natal Basin and the Outeniqua Basin). But, the structure and overall kinematic evolution of the three major transform fault zones – such as the Agulhas, the Davie and the Limpopo fracture zones (FZ) – that together control the opening of major oceanic basins (Antarctic Ocean, Weddell Sea and Austral South Atlantic) remain poorly studied. The interpretation of an extensive regional multi-channel seismic dataset coupled with recent studies allows us to propose a detailed regional synthesis of the crustal domains and major structural elements of the rifted margins along the whole eastern and southeastern Africa. We provide new constraints on the structure and evolution of these three transform systems. Although our findings indicate common features in transform style (e.g. a right-lateral transform system, a wide sheared corridor), the deformation and magmatism along these systems appear quite different. In particular, our results show that the Davie and Agulhas transform faults postdate the development of the rift zone-controlling faults, whereas the Limpopo margin seems to be a simple intra-continental transform. Moreover, the Davie and Agulhas FZ recorded spectacular inversions during the transform stage, whereas transtensional deformation is developed along the Limpopo FZ. This different style of deformation may be explained by two main forcing parameters: (i) the far-field forces that may induce a rapid change of regional tectonic stress and (ii) the magmatic additions that modify mainly the crustal rheology. In the post-drift history, several reactivations of transform fault zones are recorded, implying that some transform margins are excellent recorders of large plate kinematic changes. Such reactivations can serve also as drains for magmatic fluids in the vicinity of hotspots emplacement.
Underground energy-related product storage and sequestration: site characterization, risk analysis and monitoring
Authors: Schultz Richard A. , Williams-Stroud Sherilyn , Horváth Birgit , Wickens John , Bernhardt Heike , Cao Wenzhuo , Capuano Paolo , Dewers Thomas A. , Goswick Raven A. , Lei Qinghua , McClure Mark , Prasad Umesh , Schwartz Brandon A. , Yu Haitao , Voegeli Samuel , Zhao Qi 
Published: September 2022

Abstract
This paper presents a high-level overview of site characterization, risk analysis and monitoring priorities for underground energy-related product storage or sequestration facilities. The siting of an underground storage or sequestration facility depends on several important factors beginning with the area of review. Collection of all existing and available records and data from within the rock volume, including potential vulnerabilities such as prior containment issues, proximity to infrastructure and/or population centres, must be evaluated. Baselining of natural processes before storage or sequestration operations begin provides the basis for assessing the effects of storage or sequestration on the surroundings. These initial investigations include geological, geophysical and geochemical analyses of the suitability of the geological host rock and environs for storage or sequestration. A risk analysis identifies and evaluates threats and hazards, the potential impact should they develop into unwanted circumstances or events and the consequences to the facility should any of them occur. This forms the basis for framing effective mitigation measures. A comprehensive monitoring programme that may include downhole well surveillance, observation wells, geochemical sampling and well testing ensures that the facility operates as designed and that unforeseen issues, such as product migration or loss of integrity, can be identified and mitigated. In addition to these technical issues, human factors and public perception of a project are a critical part of the site characterization, construction and operational phases of a project. Despite differences between underground storage and sequestration, the characterization, risk analysis and monitoring approaches that were developed for underground natural gas storage or for carbon dioxide sequestration could be used for underground storage or sequestration of any type of energy-related product. Recommendations from this work include: (1) develop an industry-standard evaluation protocol (workflow) for the evaluation of salt beds, saline aquifers, depleted hydrocarbon reservoirs, underground mines and cased wellbores for potential underground storage or sequestration development beyond those in use today; and (2) develop an industry-wide collaborative process whereby incident and near-miss data related to underground storage or sequestration operations can be reported, documented and shared for use in refining risk analysis modelling.