bluuebunny/crossref_metadata_2025_split huggingface dataset:
Process Fundamentals and Quality Investigation in Extrusion 3D Printing of Shear Thinning Materials——Extrusion Process Based on Nishihara Model
Authors: Luo Yonghao , Sun Weiwen , Bao Minle , Zhu Xiaowu , Ning Chenhong , Zhang Weiye , Li Yanhui , Zhang Xinyue 
Published: March 2022

Abstract
Due to the complexity of extrusion 3D printing objects and lack of universal parameters, there are few classified statistics or quantitative description for the "extrudability" of material with shear thinning properties. In order to systematically study the rheological properties of extrudable materials and establish a unified criterion or quality evaluation standard from the basic process theory, a Nishihara rheological constitutive model based on visco-elastic and visco-plastic characteristics of materials is explored to predict and investigate the extrusion performance of four typical dispersed-continuous phase binary mixture. The creep model result shows that, expect for the gelatin network-water system with almost complete elastic behavior, the material with shear thinning property based on Nishihara model is in good agreement with the experimental results. In the extrusion process, the shear stress is related to the advancing speed, material viscosity and nozzle size. The effects of advancing speed and nozzle size on shear stress show antagonistic characteristics in a certain range, that is, the velocity gradient is the dominant factor at lower extrusion speed, and the dynamic viscosity is the dominant factor at higher extrusion speed. In terms of extrusion properties, the material system with smaller yield strain/stress has the least obvious extrusion delay characteristics, and is easier to extrude under the condition of the same material strength.
Anthropometric, Neuromuscular, Physiologic and Training variables as determinants to Laboratory Cycling Performance
Authors: Lanferdini Fábio Juner , Kons Rafael Lima , Detanico Daniele , Pupo Juliano Dal , de Lucas Ricardo Dantas , Vaz Marco Aurélio 
Published: March 2022

Abstract

The goal of this study was to verify whether physical components (anthropometric, physiological and neuromuscular), as well as training characteristics, could predict cycling performance during maximal incremental and time-to-exhaustion tests. Twenty male cyclists volunteered to participate in this study and performed an incremental cycling ramp test. Anthropometric, training history and training volume were assessed. Second ventilatory threshold (VT2), maximal oxygen uptake (VO2MAX), and maximal power output (POMAX) were assessed during incremental test. Muscle architecture of the vastus lateralis (VL) and rectus femoris (RF) muscles was evaluated bilaterally to calculate the mean legs’ muscle thickness, pennation angle and fascicle length, at rest condition. Soon after, the cyclists performed a warm-up and the time-to-exhaustion test at POMAX. In addition, muscle activation of the VL, RF and vastus medialis (VM) muscles was evaluated through the mean root mean square value from both legs. Cyclists’ height (R2 = 0.37), experience time and training volume (R2 = 0.46) were predictors of POMAX (p<0.02), while cadence (R2 = 0.30) was the only predictive variable for the time-to-exhaustion performance (p<0.01). The main predictors of the maximal incremental cycling test performance were height, experience time and training volume, while cadence was a predictor of time-to-exhaustion.
Hierarchical Reduced Graphene Oxide-MnO2@Polypyrrole coaxial nanotube Composite Hydrogel as a Potential Adsorbent for Cr(VI) Removal
Authors: Wang Xiangyu , Du Hanwei , Ji Jiayou , Li Liang 
Published: March 2022

Abstract
A hierarchical reduced graphene oxide-MnO2@polypyrrole coaxial nanotube composite hydrogel are prepared via oxidative polymerization of pyrrole in the presence of MnO2 nanotubes, followed by the hydrothermal treatment of graphene oxide and MnO2@polypyrrole coaxial nanotubes. The stable composite hydrogel with hierarchical network is composed of one-dimensional MnO2@polypyrrole coaxial nanotube and two-dimensional graphene nanosheet and characterized by scanning electron microscope, Fourier transform infrared spectroscopy, X-ray diffraction, Brunauer-Emmett-Teller surface, and X-ray photoelectron spectroscopy measurements. The composite hydrogel can be used as an efficient adsorbent for Cr(Ⅵ) removal due to the synergistic interaction between graphene and MnO2@polypyrrole and the hierarchical structure of the hydrogel. Moreover, the composite hydrogel is easily separated because of its stable monolith, and reusable (76.8% of removal ability remaining after five adsorption-desorption cycles). The simple fabrication and cost-effective separation process together with the excellent absorption performance endows the composite hydrogel with great potential for practical wastewater treatment.
Seroprevalence of Hepatitis C Virus in Jinan, China, 2008–2020
Authors: Xu Mingjie , Liu Fang , Zhao Qianqian , Zhou Yunying , Zhuang Yuanmei , Ji Mingyu 
Published: March 2022

Abstract
Background:Updated estimate of anti-HCV prevalence is critical for developing strategies to manage or eliminate HCV infection. To achieve this, a comprehensive study was conducted for the seroprevalence of HCV among patients in Jinan Central Hospital, China. Methods: From 2008 to 2020, 365,210 patients were tested for anti-HCV, core antigen of Hepatitis C Virus (HCV cAg), hepatitis B surface antigen (HBsAg), syphilis antibody (anti-TP), HIV antigen+antibody (Ag+Ab) assays, anti‑HAV IgM and anti‑HEV IgM.Results:The HCV seroprevalence was 0.79%. HCV seroprevalence is related to age distribution, the children (<18 years) had a lower HCV seropositivity 0.15%, and among adults ( ≥18 years) was 0.81%. A increasing prevalence of HCV was found in adults aged greater than or equal to 41 years, the HCV seropositivity for those aged between 41 to 80 accounted for 74.56% of all seropositiveindividuals. Surprisingly, rate of HCV-HIV co-infection was 0. The HCV seroprevalence of patients in Kidney Disease Unit & Dialysis Department was much higher than patients in other departments, whether in inpatients or outpatients.Conclusions:A lower HCV seroprevalence in Jinan, but a higher HCV seroprevalence in Kidney Disease Unit & Dialysis Department, especially in patients on hemodialysis.
A Prognostic Nomogram for Patients with Stage II/III Rectal Cancer Undergoing Surgical Resection after Neoadjuvant Chemoradiotherapy
Authors: Lin Yanfei 
Published: March 2022

Abstract
Background: The purpose of this study was to create a nomogram incorporated on log odds of positive nodes (LODDS) for predicting the overall survival (OS) of patients with stage II/III rectal cancer who underwent surgical resection after neoadjuvant chemoradiotherapy (NCRT).Methods: The Surveillance, Epidemiology, and End Results database was used to collect information on patients diagnosed with stage II/III rectal cancer who underwent surgical resection after neoadjuvant chemoradiotherapy between 2010 and 2015. The Cox regression analyses were performed to determine the independent prognostic factors. In this study, LODDS was employed instead of American Joint Committee on Cancer (AJCC) 7th N stage to determine lymph node status. Then a nomogram integrating independent prognostic factors was created to predict the 24-, 36-, and 60-month overall survival of patients. The receiver operating characteristic (ROC) curves and calibration curves were used to evaluate the nomogram. Furthermore，patients were stratified into three risk groups(high-, middle-, and low-risk) based on the total points obtained from the nomogram using X-tile software. And Kaplan-Meier curves were plotted to compare OS of the three groups.Results: A total of 3,829 patients were included in the study. Race, sex, age, marital status, T stage, tumor grade, tumor size, LODDS, CEA level, and postoperative chemotherapy were identified as independent prognostic factors. Then the prognostic nomogram was created and evaluated. The ROC curves and calibration curves showed good performance of the prognostic nomogram. The Kaplan-Meier curves showed that the three risk groups had significant differences in overall survival.Conclusion: The LODDS-incorporated prognostic nomogram was created and showed satisfactorily discriminative and stable ability to predict the OS of patients with stage II/III rectal cancer undergoing surgical resection after NCRT. It is convenient to access the risk factors included in this nomogram in clinical practice. The nomogram is expected to be a useful tool in developing individualized treatment strategies and follow-up protocols.
Short term inhibition of immune checkpoint proteins increases ex vivo expansion of tumour infiltrating lymphocytes in high grade serous ovarian cancer
Authors: Waddell Caitlin A , Price Marcus J. , Cheadle Eleanor J. , Owens Gemma L. , Edmondson Richard J. 
Published: March 2022

Abstract
Background: Ovarian cancer remains the most lethal gynaecological malignancy and there is an urgent need for the development of further therapies to improve patient survival. Tumour infiltrating lymphocyte (TIL) therapy has shown clear efficacy in immunogenic cancers, and TIL can be readily expanded ex vivo from samples of high grade serous ovarian cancer (HGSOC). Antibodies against checkpoint proteins are effective in increasing TIL yield and functional response from ovarian cancer TIL cultures, potentially increasing TIL product efficacy. However, it is unknown whether blockade of other key checkpoints, including programmed death ligand-1 (PD-1), T cell immunoglobulin mucin-3 (TIM-3) and lymphocyte activation gene-3 (LAG-3) increase TIL yield in ex vivo cultures from HGSOC samples.Materials and Methods: TIL cultures were generated from fresh tissue samples and were incubated with CD3/CD28 Dynabeads® and IL-2. TIL were grown with or without the addition of 10µg/mL αPD-1, αTIM-3 or αLAG-3 antibodies as either single or repeated applications for 19 days. The phenotype of cultures was analysed by multiparameter flow cytometry. Interferon gamma (IFN-ᵧ) release in response to TIL co-culture with autologous tumour cultures or digests was measured by ELISA. Results: In keeping with previous findings the majority of TIL expressed at least one checkpoint protein. Specifically, TIL expressing PD-1 and TIM-3 retained a functional phenotype with co expression of OX40 and CD28. Expansion of TIL was increased following a single exposure to αPD-1 (1.20 fold) and αLAG-3 (1.31 fold) which was most marked in cultures with otherwise low proliferation. There was no additional increase in proliferation following repeated dosing. In co-culture with autologous tumour, TIL grown in the presence of checkpoint inhibitors showed increased IFN-ᵧ release suggesting increased functional activity in individual cultures. However, this response was not uniform across all cultures. Conclusions: These data suggests that initial blockade of checkpoint proteins is effective in increasing the yield of TIL expanded from HGSOC tumours, suggesting that checkpoint inhibition during TIL manufacture may be a useful method of increasing expansion efficiency.
Second Booster Vaccine and Covid-19 Mortality in Adults 60 to 100 Years Old
Authors: Arbel Ronen , Sergienko Ruslan , Friger Michael , Peretz Alon , Beckenstein Tanya , Yaron Shlomit , Netzer Doron , Hammerman Ariel 
Published: March 2022

Abstract
The rapid emergence of the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus-2 led to a global resurgence of coronavirus disease 2019 (Covid-19). Israeli authorities approved a 4th Covid-19 vaccine dose (second-booster) for individuals aged 60 and above who received a first booster dose four or more months earlier. Evidence regarding the effectiveness of a second-booster dose in reducing mortality due to Covid-19 is warranted. This retrospective cohort study included all members of Clalit Health Services, aged 60 to 100, eligible for the second-booster. Mortality due to Covid-19 among participants who received the second-booster was compared with participants who received one booster dose. A Cox proportional-hazards regression model with time-dependent covariates was used to estimate the association between the second-booster and death due to Covid-19 while adjusting for demographic factors and coexisting illnesses. A total of 563,465 participants met the eligibility criteria. Of those, 328,597 (58%) received a second-booster dose during the 40-day study period. Death due to Covid-19 occurred in 92 second-booster recipients and in 232 participants who received one booster dose (adjusted hazard ratio 0.22; 95% confidence interval 0.17 to 0.28). This study demonstrates a substantial reduction in Covid-19 mortality by the second-booster in eligible subjects.
Modified Technique for Corneal Laceration Repair Using Amniotic Membrane.
Authors: Elkadim Mohamed , Elgohary Asmaa M , Alhelaly Mai Brakat , Sharaf Amr F. 
Published: March 2022

Abstract

Purpose: To describe technique and evaluate outcomes of using amniotic membrane onlay strip for repair of corneal lacerations.Methods: Retrospective case series included eight eyes with traumatic corneal lacerations. A strip of amniotic membrane was applied to the corneal surface to cover the wound. Wound was then sutured with nylon 10/0 sutures involving the membrane. Sutures were well-spaced and suturing was avoided in the visual axis. Average keratometric reading (average K), keratometric astigmatism (KA), manifest refractive astigmatism (RA) in diopters (D) and spectacle or soft contact lens best corrected visual acuity (BCVA) were assessed 2 months after suture removal. Results: Transient postoperative hypotony was encountered in five cases (62.5%). Average K was 44.61 ± 2.81 D (mean± SD). KA was 2.20±0.71 D (mean± SD). RA was 1.78 ± 0.73 D (mean± SD) and ranged from 1 to 3 D. Log MAR BCVA was 0.39±0.18 (mean± SD) ranged from 0.22 to 0.70.Conclusions: The application of amniotic membrane onlay strip during repair of corneal lacerations was associated with good visual outcome possibly due to reduction of wound and suture related corneal astigmatism.
The Outcomes of Vitrified Oocytes Accumulation for Managing Diminished Ovarian Reserve: A retrospective cohort study
Authors: Lee Kuan-Sheng , Lin Ming-Huei , Hwu Yuh-Ming , Yang Jia-Hwa , Lee Robert Kuo-Kuang 
Published: March 2022

Abstract
Background: Vitrified M-II oocytes accumulation strategy for later simultaneous insemination has been used for managing POR. Our study aimed to determine whether simulation insemination of vitrified oocytes accumulation strategy improves live birth rate (LBR) for managing diminished ovarian reserve (DOR).Methods: Retrospective study included 440 women with DOR fulfilling Poseidon classification groups 3 and 4, defined as presence of serum anti-Müllerian hormone (AMH) hormone level <1.2 ng/ml or antral follicle count (AFC) <5, from January 1, 2014 to December 31, 2019 in a single department. Patients underwent accumulation of vitrified oocytes (DOR-Accu) and embryo transfer (ET) or controlled ovarian stimulation (COS) using fresh oocytes (DOR-fresh) and ET. Primary outcomes were LBR per ET and cumulative LBR (CLBR) per intention to treat (ITT). Secondary outcomes were clinical pregnancy rate (CPR) and miscarriage rate (MR).Results: 211 patients underwent simultaneous insemination of vitrified oocytes accumulation and ET in DOR-Accu group (maternal age: 39.29 ± 4.23 y, AMH: 0.54 ± 0.35 ng/ml), and 229 patients underwent COS and ET in DOR-fresh group (maternal age: 38.07 ± 3.77 y, AMH: 0.72 ± 0.32 ng/ml). CPR in DOR-Accu group were similar in DOR-fresh group (27.5% vs. 31.0%, p = 0.418). MR was statistically higher (41.4% vs. 14.1%, p = 0.001) while LBR per ET was statistically lower (15.2% vs. 26.2%, p < 0.001) in DOR-Accu group. There is no difference in CLBR per ITT between groups (20.4% vs. 27.5%, p = 0.081). Clinical outcomes were categorized in four groups with regard to patient’s age in secondary analysis. CPR, LBR per ET, and CLBR did not improved in DOR-Accu group. In group of 31 patients, accumulated vitrified metaphase II (M-II) oocytes reach total number ≥15, CPR improved among DOR-Accu group (48.4% vs. 31.0%, p = 0.054); however, higher MR (40.0% vs. 14.1%, p = 0.03) resulted similar LBR per ET (29.0% vs. 26.2%, p = 0.738).Conclusions: Vitrified oocytes accumulation for managing DOR did not improve LBR. Higher MR resulted in lower LBR. Vitrified oocytes accumulation strategy for managing DOR is not clinically practical.Trial registration: The study protocol was retrospectively registered and was approved by Institutional Review Board of Mackay Memorial Hospital (21MMHIS219e) on August 26, 2021
Evaluation of numerical method combinations for transport-dominated problems in the chemistry transport model (CHIMERE): Ozone prediction and Computing optimization study
Authors: Ajdour Amine , Leghrib Radouane , Chaoufi Jamal , Chirmata Ahmed 
Published: March 2022

Abstract
Ozone concentration generally affects a health system, including human health, and an ecosystem, including plant properties and soil processes. Based on high-performance computing, this study used the transport chemistry model CHIMERE to model ozone pollution in the city of Agadir. The aim is to investigate the integrating horizontal and vertical transport effect on ozone concentration and computation time. The findings are validated experimentally by measurements and also compared with other studies. The results highlighted four main points: First, the CHIMERE ozone modeling remains acceptable with a correlation coefficient of 70%. Second, the combination Adv00 based on the Upwind method gives good results in terms of ozone concentration with a significant implementation time, equivalent to 80 minutes for 360 hours of prediction, which means an optimization in computational performance. Third, it is required to optimize all possible parts of the modeling process to reduce costs and time. Fourth, detailed local emission information is recommended to get a clearer picture of the correction of the CHIMERE output. The present work can serve as guidance for the CHIMERE settings in the case of limited computational infrastructure for long-term studies and studies using a high spatial resolution to predict polluted air.
Double-nosed Low-Level Jet in Complex Terrain: a model from Inertial Oscillations
Authors: Barbano Francesco , Leo Laura Sandra , Brogno Luigi , Sabatino Silvana Di 
Published: March 2022

Abstract
In this paper, an analytical model based on inertial oscillations (Van15 De Wiel et al, 2010) is used to replicate the evolution on a LLJ in complex terrain and then modified to diagnose the occurrence of a double-nosed LLJ driven by surface wave activity. Using an already-analysed case study from the Mountain Terrain Atmospheric Modeling and Observations (MATERHORN) dataset, we test the performance of the model in capturing (i) the role of the inertial oscillations in the evolution of a nocturnal LLJ in a wide and gentle-sloping valley, and (ii) the shape modification of the wind profile at the occurrence of the double-nosed LLJ. The modifications applied to the model are framed on the wave-driven mechanism theorized by Brogno et al (2021), without losing the simplicity of the original model framework. A unified model integrating the original with the modified versions is proposed, revealing accurate in replicating the nocturnal LLJ and appropriate to approximate the double-nosed shape of the LLJ. Further observational studies will be needed to corroborate the unified model and explore its application potential in different wind and energy sectors.
Well-posedness and global attractor of Kirchhoff equation with memory term and thermal effect
Authors: LV Penghui , LIN Guoguang , LV Xiaojun 
Published: March 2022

Abstract
The Kirchhoff equation with thermal effect and memory term is studied. The existence and uniqueness of the solution of the equation are obtained by using the Faedo-Galerkin method. Secondly, the existence of global attractor is obtained by proving the existence of bounded absorption set and the asymptotic smoothness of semigroup. For the first time, this paper comprehensively considers the long-term dynamic behavior of the Kirchhoff model under the simultaneous action of variable coefficients, memory and thermal effects, and promotes the relevant conclusions of the Kirchhoff model. The conclusion of this paper provides a theoretical basis for the subsequent research.
Perceived Risk and Severity of the Uptake of Safe Male Circumcision Services among Young Men Aged 15-24 Years in Rhino Camp Refugees Settlement, Arua District- Uganda
Authors: David Blate M. , Bandaru Juliet M. , Namajja Khawa E. , Kajoba David , Atuhaire Shallon 
Published: March 2022

Abstract
Background: Safe male circumcision is a proven cost-effective intervention in reducing the risk of sexual transmission of Human Immunodeficiency Virus /Acquired Immune Deficiency Syndrome among heterosexual individuals by 60%. This study aimed at exploring the perceived risk and severity to the uptake of safe male circumcision among young men aged 15-24 years in Rhino Camp Refugees Settlement, Arua District, Uganda.Methods: This was a cross-sectional study among 378 respondents, which utilized both quantitative and qualitative approaches with a semi-structured and three focus group discussions conducted among young men aged 15-24 years. Univariate analysis was used to determine the uptake of safe male circumcision. Chi-square test and binary regression model were used to determine the odds ratio at 95% confidence levels of safe male circumcision uptake and other exposure variables. Results from the focus group discussions were analysed thematically.Results: The prevalence of safe male circumcision uptake was 42.1%. The major factor associated with increased likelihood of safe male circumcision uptake was the perceived benefit of cervical cancer prevention in my partner (AOR=2.455, 95% CI= 1.278- 3.627). Factors associated with reduced likelihood of safe male circumcision uptake included: fear of perceived increased risk of meatitis (AOR=0.726, 95% CI=0.338- .959), fear that undergoing safe male circumcision is very painful and uncomfortable (AOR= 0.742, 95%, CI= 0.279- 1.973). Also, the perception that safe male circumcision is not affordable at most private health facilities (AOR=0.167, 95%, CI=0.058- 0.478). Conclusions: Safe male circumcision uptake in Rhino Refugees Settlement is lower than Uganda’s national target of 80%. This is attributed to the perceived risks such as risk of infection, pain, irritability, and costs involved. Awareness creation on myths and misconceptions is key to increasing uptake of safe male circumcision.
Depression, Anxiety and Stress Among Dentists During COVID-19 Lockdown
Authors: Al-Rawi Natheer H. , Uthman Asmaa T. , Saeed Musab , Abdulkareem Ali A. , Al Bayati Sura , Al Nuaimi Ahmed 
Published: March 2022

Introduction:The objective of this study was to investigate the levels of depression, anxiety, and stress among dentists during covid-19 lockdown and to investigate the relationship between stress and each mental health state.Methods:A cross-sectional survey on 269 dentists was conducted using DASS-21 and PHQ-9 questionnaires. Bivariate and multivariate models were constructed and the odds ratio (OR) was calculated to assess the strength of the association between an independent categorical variable and the outcome.Results and Discussion:Being unsatisfied with the job was associated with a statistically significant increase in DASS-21 score by an average of 5.9 points after adjusting for the possible confounding effect of the other independent variables included in the model. For each extra 10 years of clinical experience, there is a statistically significant reduction in DASS-21 score by an average of 1.3 points compared after adjusting for the possible confounding effect of the other independent variables included in the model.Conclusion:Stress, depression, and anxiety were prevalent during the pandemic among dentists. These psychological domains were modulated by several factors including marital status, gender, years of clinical experience, and degree of job satisfaction.