bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desmoid fibromatosis in the pharyngeal wall: A case report and literature review
Authors: Geisenhainer Katharina , Klenke Daniela , Moser Norman , Kurbad Oliver , Bremmer Felix , Kauffmann Philipp , Schliephake Henning , Brockmeyer Phillipp 
Published: January 2022

AbstractDesmoid fibromatosis (DF) is one of the rarest locally aggressive growing benign tumor entities. We present an overview of the literature and a rare clinical case of a 22‐year‐old female patient, who was diagnosed with aggressive DF in the left pharyngeal wall at the age of 4 years old.
A covalent organic framework for chiral capillary electrochromatography using a cyclodextrin mobile phase additive
Authors: Gao Lidi , Zhao Xuan , Qin Shili , Dong Qing , Hu Xingfang , Chu Hongtao 
Published: January 2022

AbstractCovalent organic frameworks (COFs) have been recognized as promising solid phases in capillary electrochromatography (CEC). Imine‐based COF‐coated open‐tubular CEC column (COF TpBD‐coated OT column) was prepared and characterized by X‐ray diffraction (XRD), Fourier‐transform infrared (FT‐IR) spectra, thermogravimetric analysis (TGA), nitrogen adsorption/desorption (Brunauer–Emmett–Teller [BET]), and scanning electron microscopy (SEM). The results showed that the column efficiency was up to 26,776 plate/m, and the thickness of stationary phase was about 6.00 μm for the column prepared under the optimal conditions. Enantioseparation of 15 kinds of the single chiral compounds (histidine, arginine, lysine, leucine, threonine, methionine, valine, aspartic acid and glutamic acid, fipronil, diclofop, imazamox, quizalofop‐p, imazethapyr, and acephate) and 3 kinds of mixed amino acids racemaces (valine, methionine, and glutamic acid) were performed with three methods: capillary electrochromatography with COF TpBD‐coated OT column (Method 1), CEC with COF TpBD‐coated OT column as the separation channels, and capillary electrophoresis (CE) with HP‐β‐CD as the chiral mobile phase additive (Method 2) and CE with HP‐β‐CD as the chiral mobile phase additive (Method 3). Separation efficiency and chiral selectivity of Method 2 was best among the three methods. Under the optimal separation conditions of Method 2, all the enantiomers reached the baseline separation regardless of the single chiral compounds or the mixed amino acids. Relative standard deviation (RSDs) of the mean column efficiency for reproducibility and stability was in the range of 0.46–1.49%. This combination of CEC and CE has great potential for use in chiral separation.
Porous Assembly of Metallo‐Supramolecule and Polyoxometalate via Ionic Complexation with Vapor Sorption Properties
Authors: Xu Yaping , Yu Hao , Jiang Xin , Shi Junjuan , Li Bao , Li Lu , Wu Lixin , Wang Ming 
Published: January 2022

Comprehensive SummaryPorous materials have been extensively developed and displayed special applications in diverse fields, however, it still remains a great challenge in developing new synthetic methods with features of energy‐saving and easy‐operating. In this study, we reported the construction of a series of novel ionic complexes based on discrete supramolecular triangle structure and polyoxometalate [Mo6O19]2–, using a quite efficient strategy. The obtained composites exhibit precise 3D network structures with ideal stability containing micropores, which were characterized by the 1H NMR, ESI‐MS, TEM, SEM, and single‐crystal X‐ray diffraction. These composites showed differential vapor adsorption behaviors for benzene, toluene, and cyclohexane. This work provides a novel approach for fabricating porous materials through electrostatic interactions and has great potential for gas separation.
PROTOCOL: Testing frequency and student achievement: A systematic review
Authors: Thomsen Morten K. , Seerup Julie K. , Dietrichson Jens , Bondebjerg Anja , Viinholt Bjørn C. A. 
Published: January 2022

AbstractThis is the protocol for a Campbell review. Our primary research question is: What are the effects of different testing frequencies on student achievement? Our secondary research question is: What are the effects of different testing frequencies on measures of students' testing anxiety? Our third research question is: How are the effects of different testing frequencies on student achievement and testing anxiety moderated by subject, grade, type of test, duration of the intervention, and gender?
Allergy to polyethylene glycol and polysorbates in a patient cohort: Diagnostic work‐up and decision points for vaccination during the COVID‐19 pandemic
Authors: Mortz Charlotte G. , Kjaer Henrik F. , Rasmussen Trine H. , Rasmussen Helene M. , Garvey Lene Heise , Bindslev‐Jensen Carsten 
Published: January 2022

AbstractBackgroundDuring the COVID‐19 pandemic focus has been on polyethylene glycol (PEG) and polysorbate as these excipients are constituents in the first vaccines and possible elicitors of allergic reactions to the vaccines. We aimed to evaluate the possibility of vaccinating patients with PEG and/or polysorbate allergy against COVID‐19.MethodsTwenty‐five patients with a history of an allergic reaction to drugs, vaccines and mouth hygiene products containing PEG or polysorbate and sensitization (skin test or in vitro test) or a positive challenge were included. We re‐evaluated 19 of 21 patients diagnosed before 2021 and four new patients by skin prick tests (SPT) and Basophil Histamine Release (BaHR) for PEGs, polysorbates and approved COVID‐19 vaccines as well as measurement of specific IgE (PEG 2000, 10,000). Patients were offered vaccination based on decision points from the primary diagnosis and re‐evaluation.ResultsMost common primary elicitors were depot‐steroids and laxatives. Most patients had experienced more than one reaction. SPT was superior to BaHR test although many SPTs became negative over time. After careful re‐evaluation three patients were successfully vaccinated with the Pfizer/BioNTech vaccine. Three were vaccinated before referral. Eleven were offered the Johnson‐Johnson vaccine; four were vaccinated successfully, seven abstained. Six patients could not be vaccinated with PEG or polysorbate containing vaccines.ConclusionHypersensitivity to excipients in COVID‐19 vaccines constitutes a risk to patients with allergy to PEG or polysorbates. After diagnostic evaluation, a safe COVID‐19 vaccine could be offered to most patients, the remainders will await new vaccines containing different excipients.
Comparison of numerical methods for cerebrospinal fluid representation and fluid–structure interaction during transverse impact of a finite element spinal cord model
Authors: Rycman Aleksander , McLachlin Stewart , Cronin Duane S. 
Published: January 2022

AbstractSpinal cord impacts can have devastating consequences. Computational models can investigate such impacts but require biofidelic numerical representations of the neural tissues and fluid–structure interaction with cerebrospinal fluid. Achieving this biofidelity is challenging, particularly for efficient implementation of the cerebrospinal fluid in full computational human body models. The goal of this study was to assess the biofidelity and computational efficiency of fluid–structure interaction methods representing the cerebrospinal fluid interacting with the spinal cord, dura, and pia mater using experimental pellet impact test data from bovine spinal cords. Building on an existing finite element model of the spinal cord and pia mater, an orthotropic hyperelastic constitutive model was proposed for the dura mater and fit to literature data. The dura mater and cerebrospinal fluid were integrated with the existing finite element model to assess four fluid–structure interaction methods under transverse impact: Lagrange, pressurized volume, smoothed particle hydrodynamics, and arbitrary Lagrangian–Eulerian. The Lagrange method resulted in an overly stiff mechanical response, whereas the pressurized volume method over‐predicted compression of the neural tissues. Both the smoothed particle hydrodynamics and arbitrary Lagrangian–Eulerian methods were able to effectively model the impact response of the pellet on the dura mater, outflow of the cerebrospinal fluid, and compression of the spinal cord; however, the arbitrary Lagrangian–Eulerian compute time was approximately five times higher than smoothed particle hydrodynamics. Crucial to implementation in human body models, the smoothed particle hydrodynamics method provided a computationally efficient and representative approach to model spinal cord fluid–structure interaction during transverse impact.
Decreasing Crystallinity is Beneficial to the Superoxide Dismutase‐like Activity of Ceria Nanoparticles
Authors: Li Fang , Yang Lu , Zou Ling , Wu Yonghui , Hu Chengbo , He Jian , Yang Xiaochao 
Published: January 2022

AbstractCeria nanoparticles were classified as nanozymes because they are able to mimic the activities of some natural enzymes such as superoxide dismutase (SOD), catalase, oxidase and photolyase under given conditions. These functions have driven studies to explore the factors that could promote ceria nanoparticle enzyme activities. Accordingly, factors including size, shape, exposed plane and surface coating that could modulate the enzymatic activities of ceria nanoparticles have been explored. In the present study, we investigated the relationship between ceria nanoparticle crystallinity and SOD‐like activity. Two groups of ceria nanoparticles with sizes of several nanometers and tens of nanometers in each group were synthesized with different crystallinities. The ceria nanoparticle crystallinities were closely connected to their Ce3+/Ce4+ ratio, where the lower crystallinity resulted in a higher Ce3+ concentration and vice versa. The catalytic activity evaluation results indicated that the nanoparticles featuring lower crystallinity exhibited higher SOD‐like activity even though the nanoparticles had a smaller specific surface area. The crystallinity‐dominated SOD‐like activity variation could be sensed by cells, as the nanoparticles featuring lower crystallinity could better protect the cells from paraquat‐induced oxidative stress. Therefore, decreasing crystallinity could be an effective way to achieve highly active ceria nanoparticles for SOD‐related biological applications.
Comparative Pharmacokinetics Between a Fixed‐Dose Combination of Pitavastatin/Valsartan 4/160 mg and the Corresponding Individual Components Through a Partial Replicated Crossover Design in Healthy Male Subjects
Authors: Na Joo Young , Yang Eunsol , Kim Jae‐Hoon , Kwon In Sun , Jin Eun‐Heui , Yu Kyung‐Sang , Kim Jinsook , Lee SeungHwan , Hong Jang Hee 
Published: January 2022

AbstractHypertension and hyperlipidemia are often comorbid, requiring combination therapies of antihypertensive drugs and antihyperlipidemia drugs. Taking 1 fixed‐dose combination (FDC) may increase patient compliance rather than taking each of the drugs separately. This study aimed to evaluate the pharmacokinetic bioequivalence between an FDC of pitavastatin/valsartan 4/160 mg and the corresponding individual components. Considering that valsartan is a highly variable drug for maximum plasma concentration (Cmax), an open‐label, randomized, partial replicated crossover study was conducted in 54 healthy subjects. The subjects received a single oral dose of the FDC of pitavastatin/valsartan 4/160 mg in 1 period or the corresponding individual components in the other 2 periods. The geometric mean ratios and their 90%CIs of the FDC to the corresponding individual components for Cmax and area under the concentration‐time curve from time 0 to the last measurable time point were 1.05 (90%CI, 0.96‐1.15) and 0.10 (90%CI, 0.95‐1.04) for pitavastatin and 1.15 (90%CI, 1.06‐1.25) and 1.06 (0.99‐1.14) for valsartan, respectively. The geometric mean ratios (90%CIs) for area under the concentration‐time curve from time 0 to the last measurable time point and Cmax of both drugs were included in the bioequivalence criteria. In conclusion, the FDC of pitavastatin/valsartan 4/160 mg showed pharmacokinetic equivalence with the corresponding individual components.
Phase I Study of the Pharmacodynamics and Safety of Sodium Zirconium Cyclosilicate in Healthy Chinese Adults
Authors: Cheung Tommy , Sun Fang , Zhao June , Qin Yulin , Någård Mats 
Published: January 2022

AbstractSodium zirconium cyclosilicate (SZC) is an effective potassium binder for patients with hyperkalemia. This single‐center, open‐label, phase I study (NCT03283267) characterized the pharmacodynamics and safety of SZC in Chinese individuals. Twenty‐two healthy Chinese adults (mean age, 33.5 years) randomized 1:1 received daily oral SZC 5 or 10 g for 4 days, following 4 days on a low‐sodium, high‐potassium diet (continued throughout the study). End points were mean change from baseline in 24‐hour urinary potassium (primary) and sodium excretion, and serum potassium concentration. Urinary potassium excretion significantly decreased with SZC 5 g (mean change [mmol], –13.0; P < .001) and 10 g (–15.4; P < .001). Although urinary sodium excretion decreased significantly with SZC 5 g (–11.5; P = .030), there was no significant change with SZC 10 g (–5.1; P = .299). Serum potassium concentrations decreased significantly with SZC 5 g (–0.14; P = .031) and 10 g (–0.20; P = .002). All treatment‐emergent adverse events were mild, and none were considered causally related to SZC. Over 4 days, the pharmacodynamics and safety of SZC were consistent in healthy Chinese adults with global studies and patients of Japanese ethnicity.
Promoted Hydrogenolysis of Furan Aldehydes to 2,5‐Dimethylfuran by Defect Engineering on Pd/NiCo2O4
Authors: Li Xiang , Zhang Likang , Deng Qiang , Chen Shixia , Wang Jun , Zeng Zheling , Deng Shuguang 
Published: January 2022

AbstractCatalytic hydrogenolysis of biobased furan aldehydes (i. e., 5‐methylfurfural, 5‐hydroxymethylfurfural) to 2,5‐dimethylfuran has gained extensive interest for biomass‐derived fuels and chemicals. Herein, a class of NiCo2O4‐supported palladium with considerable oxygen defects was synthesized by hydrogen plasma etching and phosphating methods. The oxygen defects not only promoted the hydrogenation of the C=O group but also enhanced the accessibility of coordinatively unsaturated metal cations with Lewis acidity for the hydrogenolysis of the C−OH group. Meanwhile, the additional Brønsted acidity in Pd/NiCo2O4‐x obtained by phosphating could further strengthen the hydrogenolysis ability by the etherification route of C−OH. Finally, Pd/NiCo2O4‐x exhibited the most effective performance with 2,5‐dimethylfuran yields of 92.9 and 90.5 % from 5‐methylfurfural and 5‐hydroxymethylfurfural, respectively. These catalytic mechanisms were confirmed by in‐situ infrared spectroscopy and control experiments. Furthermore, the catalyst showed outstanding recycling stability. This work shows powerful synergistic catalysis in the hydrogenolysis reaction by multifunctional active sites.
Enhanced Hydrogenation of Levulinic Acid over Ordered Mesoporous Alumina‐Supported Catalysts: Elucidating the Effect of Fabrication Strategy
Authors: Raguindin Reibelle Q. , Desalegn Bezawit Z. , Vishwanath Hiremath , Gebresillase Mahlet N. , Seo Jeong Gil 
Published: January 2022

AbstractIn this work, three types of alumina‐supported bimetallic Ni−Cu catalysts [Ni−Cu/commercial non‐ordered mesoporous alumina (CMA), Ni−Cu/ordered MA (OMA), and Ni−Cu−OMA] were prepared via different fabrication strategies and investigated in the conversion of levulinic acid (LA) into γ‐valerolactone and 2‐methyltetrahydrofuran (2‐MTHF). This study employed characterization techniques and reactions to reveal the effects of the fabrication strategy on the activities of the catalysts. It was observed that the catalysts constructed on OM supports (Ni−Cu/OMA and Ni−Cu−OMA) displayed superior catalytic performance compared to those constructed on CM supports (Ni−Cu/CMA). Specifically, Ni−Cu−OMA, which was fabricated via the one‐pot evaporation‐induced self‐assembly strategy, exhibited the best catalytic performance, achieving a complete conversion of LA and a high selectivity of 73.0 % toward 2‐MTHF in a solvent‐free reaction environment. The promising activity of Ni−Cu−OMA was ascribed to the well‐dispersed active sites within the framework of the support, the enhanced metal‐support interaction, and the highly efficient exploitation of the synergistic effect between Ni and Cu. Detailed post‐characterization techniques were also employed to highlight the outstanding stability of Ni−Cu−OMA.
A rendezvous point‐based data gathering in underwater wireless sensor networks for monitoring applications
Authors: Choudhary Monika , Goyal Nitin 
Published: January 2022

SummaryIn underwater wireless sensor networks (UWSNs), most of the mobile sink data gathering scheme assumes that sensor nodes are static. Also, very limited set of works aim to eliminate the data redundancy during data gathering. Moreover, the data collection latency, error rate and load have to be considered in addition to the buffer space and energy level of the nodes. Here, a mobile sink data gathering technique is designed where rendezvous points (RPs) and sojourn times are selected. The RPs, where the mobile sinks stop to gather the data, are selected based on the node density, current traffic load and energy level of nodes. The proposed scheme, that is, adaptive distributed mobile sink data gathering (ADMSDG), eliminates data redundancy even by considering mobility of all the nodes including sink node. Here, multihop data gathering is also considered to address the energy hole problem near the sink based on similarity index. To examine the result, proposed scheme and other state‐of‐the‐art schemes are implemented in NS2.30 having the same environment. Obtained results show that when proposed scheme is experimented with respect to number of nodes, the proposed ADMSDG technique achieves 18% high data collection accuracy with 5% reduced data collection delay and 5% less energy consumption. Similarly, when proposed scheme is experimented with respect to transmission range, the proposed ADMSDG technique achieves 18% high data collection accuracy with 12% reduced data collection delay and 8% less energy consumption.
Adulteration of low‐delta‐9‐tetrahydrocannabinol products with synthetic cannabinoids: Results from drug checking services
Authors: Monti Manuela Carla , Zeugin Jill , Koch Konrad , Milenkovic Natasa , Scheurer Eva , Mercer‐Chalmers‐Bender Katja 
Published: January 2022

AbstractSince late 2019, low‐delta‐9‐tetrahydrocannabinol (THC) preparations adulterated with synthetic cannabinoids (SCs) have been frequently observed in Switzerland. The unawareness of users concerning the presence of SCs and the typically higher potency and toxicity of SCs, when compared with THC, can result in increased health risks. In Switzerland, low‐THC (<1%) cannabis products, except hashish, are legal. These products can act as carrier materials for SCs. In this study, cannabis samples and user self‐reports received through three drug checking services were collected and analysed, to gain deeper insight into this new phenomenon. Samples were collected from January 2020 to July 2021. Liquid chromatography coupled with high‐resolution mass spectrometry was used for the qualitative screening and semi‐quantification of SCs, while gas chromatography with flame ionization detector was applied for the quantification of THC and cannabidiol levels. Reported adverse effects were compared between users who consumed adulterated (SC‐group) and non‐adulterated (THC‐group) products. Of a total 94 samples, 50% contained up to three different SCs. MDMB‐4en‐PINACA was most often detected. All adulterated cannabis flowers contained ≤1% THC. Adulterated hashish also typically presented low THC‐levels (median: 0.8%). The SC‐group was associated with higher numbers of adverse events (p = 0.041). Furthermore, psychologic (p = 0.0007) and cardiologic (p = 0.020) adverse effects were more profound in the SC‐group than in the THC‐group. Drug checking services enabled the timely detection and monitoring of new and potentially dangerous trends. Furthermore, due to user‐reports, additional valuable information was gained on adverse events associated with the consumption of novel SCs.
Antemortem and postmortem rodenticide analysis in forensic toxicology as a part of an LC‐MS/MS‐based multi‐target screening strategy
Authors: Arens Annabel , Teske Jörg , Klintschar Michael , Mischke Reinhard , Dziadosz Marek 
Published: January 2022

AbstractSince rodenticides represent a substance group relevant in toxicological analyses, the aim of this work was the development of a complex multi‐target screening strategy for the identification with liquid chromatography–tandem mass spectrometry. A simple protein precipitation was used as the sample preparation strategy. Further, a Luna 5 μm C18 (2) 100 Å, 150 × 2 mm analytical column was applied for the separation of relevant analytes with a Shimadzu HPLC. Signal detection was performed with a SCIEX API 5500 QTrap MS/MS system. The rodenticides investigated (α‐chloralose, brodifacoum, bromadiolone, coumatetralyl, difenacoum, and warfarin) could be incorporated effectively into a multi‐target screening strategy covering about 250 substances representing different groups with a limit of detection appropriate for substance identification. The strategy can easily be modified to perform semi‐quantitative measurements for this substance group and could be supplemented by quantification based on standard addition.
Reporting racial and ethnic diversity in eating disorder research over the past 20 years
Authors: Egbert Amy H. , Hunt Rowan A. , Williams Kayla L. , Burke Natasha L. , Mathis Karen Jennings 
Published: January 2022

AbstractObjectiveRecent public awareness of racial and ethnic disparities has again brought to light issues of diversity, equity, and inclusion in the eating disorders field. However, empirical information on racial and ethnic representation in eating disorders research is limited, making it difficult to understand where improvements are needed.MethodThis study reviewed all studies including human participants published in the International Journal of Eating Disorders in 2000, 2010, and 2020. Differences in likelihood of reporting race and ethnicity were calculated based on study year, location, and diagnostic categories.ResultsOut of 377 manuscripts, 45.2% reported information on the race and ethnicity of study participants. Studies conducted in the United States were more likely to report (128/173), and those conducted in Europe were less likely to report (5/61) on race and ethnicity than those conducted outside of those regions. Rates of reporting increased from 2000 to 2020. White participants made up approximately 70% of the samples that reported race and ethnicity data. Hispanic participants made up approximately 10% of samples reporting race and ethnicity. Participants from all other races and ethnicities made up less than 5% each.DiscussionAlthough rates of reporting race and ethnicity increased over time, most participants were White. Rates of reporting also differed by the geographical region, which may reflect variability in how information on race and ethnicity is collected across countries. More attention toward capturing the cultural background of research participants and more inclusivity in research are needed in the eating disorders field.