bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pieter de Hooch’s window shutter with the Habsburg Emperor Charles V (1661)
Authors: den Hartog Elizabeth 
Published: December 2022

This article deals with Pieter de Hooch’s enigmatic painting Woman holding a basket with beans in a garden of 1661 (Kunstmuseum, Basel), and, more specifically, with the identity of the man depicted on the window shutter of the building in the foreground of the painting. The author argues that this portrait, which was hidden behind a layer of paint for a long time and only uncovered sometime between 1913-1927, represents the Emperor Charles V, whose portrait still decorates many buildings in the Netherlands. It is also argued that the building in the background of the painting can be typified as a ‘hofje’ or almshouse, and that its architecture resembles that of the Leiden Eva van Hoogeveenshofje, built by the architect Arent van ‘s-Gravesande in the 1650s. This suggests that De Hooch did not only paint locations in Delft and Amsterdam, but also in Leiden.
The Dutch Republic’s seventeenth-century ‘hofjes’ were renowned, eliciting praise from foreign visitors, not only because of the way the Dutch Calvinist elite took care of the needy but also because of their superb architecture that enhanced the beauty of the Republic’s cities. Interestingly, De Hooch painted a servant girl in the garden of the almshouse, which at first may seem incongruous with an institution intended for the poor. However, as will be shown, residents of almshouses in the seventeenth-century Dutch Republic were not as poor as is generally thought. Some were even quite well-off and did indeed keep servants. In fact, some contemporaries even likened the Dutch almshouses to palaces. The portrait of the emperor on the window shutter may thus have criticised this type of ‘poor relief’ and could well have been intended to bring out the resemblance between the ‘hofje’ and an emperor’s palace. The word ‘hofje ‘ after all means ‘small court’.
As such an overt criticism is unique in De Hooch’s oeuvre, it may have been the artist himself who blotted the emperor’s portrait out, thus changing the image into a straightforward genre scene. It was precisely this type of scene that was to bring De Hooch some success following his move to Amsterdam in 1660.
‘Popish Pelagianism’ or the Work of Divine Providence?
Authors: Wood Joseph 
Published: December 2022

Abstract
Responding to John Piper’s book, Providence (2020), and building on the work of Howard Snyder, this article articulates a Wesleyan-Arminian theology of ‘prevenient grace’. Highlighting Philippians 2:12–13, prevenient grace is articulated as a theological concept, rooted in the Bible, clearly expressed in the writings of James Arminius and made more widely accessible by the teaching of John Wesley. The theology of prevenient grace has been debated through the centuries and continues to be a primary point of distinction between those who would align their thinking to John Calvin (and Calvinism), in opposition to those who align with the teachings of John Wesley (and Wesleyan/Arminianism). From the perspective of God’s providence, the article identifies the slight, yet profound, difference between irresistible and prevenient grace. It argues that the caricature of Arminius’s, and therefore, Wesley’s teaching as Pelagian is unfounded. It concludes with suggestions of how the theology of prevenient grace offers a helpful framework for pastoral care.
Evolutionary genetics of flipper forelimb and hindlimb loss from limb development-related genes in cetaceans
Authors: Sun Linxia , Rong Xinghua , Liu Xing , Yu Zhenpeng , Zhang Qian , Ren Wenhua , Yang Guang , Xu Shixia 
Published: December 2022

Abstract
Background
Cetacean hindlimbs were lost and their forelimb changed into flippers characterized by webbed digits and hyperphalangy, thus allowing them to adapt to a completely aquatic environment. However, the underlying molecular mechanism behind cetacean limb development remains poorly understood.

Results
In the present study, we explored the evolution of 16 limb-related genes and their cis-regulatory elements in cetaceans and compared them with that of other mammals. TBX5, a forelimb specific expression gene, was identified to have been under accelerated evolution in the ancestral branches of cetaceans. In addition, 32 cetacean-specific changes were examined in the SHH signaling network (SHH, PTCH1, TBX5, BMPs and SMO), within which mutations could yield webbed digits or an additional phalange. These findings thus suggest that the SHH signaling network regulates cetacean flipper formation. By contrast, the regulatory activity of the SHH gene enhancer—ZRS in cetaceans—was significantly lower than in mice, which is consistent with the cessation of SHH gene expression in the hindlimb bud during cetacean embryonic development. It was suggested that the decreased SHH activity regulated by enhancer ZRS might be one of the reasons for hindlimb degeneration in cetaceans. Interestingly, a parallel / convergent site (D42G) and a rapidly evolving CNE were identified in marine mammals in FGF10 and GREM1, respectively, and shown to be essential to restrict limb bud size; this is molecular evidence explaining the convergence of flipper-forelimb and shortening or degeneration of hindlimbs in marine mammals.

Conclusions
We did evolutionary analyses of 16 limb-related genes and their cis-regulatory elements in cetaceans and compared them with those of other mammals to provide novel insights into the molecular basis of flipper forelimb and hindlimb loss in cetaceans.
Epicardial adipose tissue thickness is related to early subclinical myocardial dysfunction, particularly in patients with type 2 diabetes mellitus: a case control study
Authors: Prestegui-Muñóz David Eduardo , Benítez-Maldonado Daniel Rabindranath , Rodríguez-Álvarez Karen , de Jesús Prestegui-Muñoz José Ángel , Melchor-López Alberto , Suárez-Cuenca Juan Antonio 
Published: December 2022

Abstract
Background
Cardiac myofibrillary dysfunction, which can be measure by echocardiographical strain value, represents an early subclinical manifestation of heart failure. Epicardial Adipose tissue (EAT) is related to low degree inflammation and oxidative damage in the adjacent tissue.

Aim
To explore whether EAT affects early myocardial dysfunction, as assessed strain values.

Methods
Case–Control design. Patients lacking clinical significant heart failure, thyroid or renal disease or malignant abnormalities were included. Clinical-demographic and biochemical data were collected. EAT and myofibril deformation were measured by echocardiography.

Results
A total of 71 patients were analyzed, and further subdivided according to type 2 Diabetes Mellitus (t2DM). Higher strain value (higher than -22.4%cut-off value) was associated with male sex and higher anthropometric and metabolic risk measures; particularly those with t2DM. Higher EAT was also associated higher strain value (AUC = 0.92 ± 0.06, p = 0.004), and further correlation was evidenced (rho = 0.488, p < 0.001), with significant influence of t2DM.

Conclusion
EAT was related to strain value, suggesting the influence of cardiac adipose tissue on the deformability of cardiac myofibril, with a more significant effect in the population with t2DM.
A multisource approach to health care use: concordance between register and self-reported physician visits in the foreign-born population in Finland
Authors: García-Velázquez Regina , Kieseppä Valentina , Lilja Eero , Koponen Päivikki , Skogberg Natalia , Kuusio Hannamaria 
Published: December 2022

AbstractBackgroundReliable information on the use of health services is important for health care planning, monitoring and policy. It is critical to assess the validity of the sources used for this purpose, including register and survey-based data. Studies on foreign-born populations’ health care use have usually implemented either survey or register data. The concordance of such data among groups of different cultural background remains largely unknown. In this study, we presented an approach to examine routinely how survey and register-related characteristics may explain disagreement found between the two information sources.MethodsWe linked register- and survey-based data pertaining to the Finnish Register of Primary Health Care general physician visits and the Survey on Well-Being among Foreign Born Population (FinMonik, 2018–2019), a nationally representative survey. The sample comprisedn = 5,800 informants for whom registered general physician visits were tracked in the 12-month period preceding their participation in the survey. Cohen’s kappa was used as measure of multisource concordance, hierarchical loglinear models for the association between single predictors and multisource discrepancy, and a logistic regression model for examining source-related predictors of source discrepancy. Survey weights were used in all sample analyses.ResultsSource concordance was poor. When dichotomizing general physician visits (zero vs one or more), 35% of informants had reported one or more visits while none were found from register. Both register- and informant-related predictors were associated to this discrepancy (i.e. catchment area, private health care use, inability to work, region of origin and reason for migration).ConclusionsWe found high discrepancy between the reported and the registered physician visits among the foreign-born population in Finland, with a particularly high number of reported physician visits when none were found in the register. There was a strong association between the specific catchment area and mismatch, indicating that both register under-coverage and survey over-report are plausible and may coexist behind the discrepancy. However, associations of informant’s characteristics and mismatch were less pronounced. Implications on the validity of medical information sources are discussed.
Elder abuse and life-course victimization in hospitalized older adults in Sweden: prevalence and associations with mental ill-health
Authors: Wiklund Nicolina , Ludvigsson Mikael , Nägga Katarina , Simmons Johanna 
Published: December 2022

AbstractBackgroundThe prevalence of elder abuse has only rarely been investigated in Sweden and never in a hospital setting. Therefore, the aims of this study were to: 1) Estimate the prevalence of elder abuse and life-course victimization among hospitalized older adults in Sweden, 2) Explore factors associated with elder abuse in the same sample, and 3) Explore the associations between life-course victimization and mental ill-health.MethodsThe study was conducted at a university hospital in Sweden. Adults over the age of 65 years admitted to a medical or geriatric acute care ward during spring 2018 were consecutively recruited. The participant rate was 44% (n = 135/306). Participants were assessed via a face-to-face interview about their experiences of elder abuse and abuse earlier in life. Mental ill-health was measured using a self-administered depression assessment (Patient Health Questionnaire-9), along with information about medications and diagnoses retrieved from medical records.ResultsAltogether, 40.7% (n = 55) of the participants reported some form of abusive experience during their life course. The prevalence of elder abuse was 17.8% (n = 24), and 58% (n = 14) of elder abuse victims also reported victimization earlier in life. Being abused before the age of 65 was the only background factor associated with elder abuse (OR = 5.4; 95% CI 1.9–15.7). Reporting abusive experiences both before and after the age of 65 was associated with current anti-depressant medication (OR = 6.6; 95% CI 1.1–39.2), a PHQ-9 result of 10 or more (OR = 10.4; 95% CI 2.1–51.0), and nine or more symptom diagnoses (OR = 4.0, 95% CI 1.0–16.1). Being abused only before or after the age of 65 was not significantly associated with any mental ill-health outcome measure.ConclusionsElder abuse and victimization earlier in life are highly prevalent among hospitalized older patients, and our findings underline the importance of a life-course perspective both in research on elder abuse and in clinical practice. Identifying and caring for older adults who have been subjected to abuse should be a priority in health care.
Association between low back pain and functional disability in the elderly people: a 4-year longitudinal study after the great East Japan earthquake
Authors: Yabe Yutaka , Hagiwara Yoshihiro , Sugawara Yumi , Tsuji Ichiro 
Published: December 2022

Abstract
Background
Functional disability is a major health issue in an aging population. Low back pain (LBP) is a common health concern that can lead to functional disability in the elderly; nonetheless, their association has not yet been clarified. This study aimed to examine the association between LBP and functional disability in the elderly, with a focus on its dose-dependent effects.

Methods
This study used the 4-year longitudinal data of people living in disaster-affected areas after the Great East Japan Earthquake (aged ≥65, n = 914). LBP and physical function were assessed at 2, 4, and 6 years after the disaster. Multivariate logistic regression analyses were performed to assess the association between LBP and low physical function, as well as the effect of preceding LBP on the onset of low physical function.

Results
LBP was significantly associated with low physical function, and the association became stronger as the duration of LBP increased. Adjusted odds ratios (95% confidence intervals) were 1.27 (0.79–2.06) in “< 2 years,” 1.95 (1.01–3.77) in “≥2 years and <4 years,” and 2.34 (1.35–4.06) in “≥4 years” (p for trend = 0.009). Additionally, preceding LBP was significantly associated with the onset of low physical function, and the effect became prominent as the duration of LBP increased. Adjusted odds ratios (95% confidence intervals) were 2.28 (1.19–4.37) in “< 2 years” and 2.82 (1.35–5.90) in “≥2 years” (p for trend = 0.003).

Conclusions
LBP is associated with physical disability among the elderly in a dose-dependent manner. Therefore, prevention and treatment of LBP are important for preventing functional disability.
Non-falciparum species and submicroscopic infections in three epidemiological malaria facets in Cameroon
Authors: Kojom Foko Loick Pradel , Hawadak Joseph , Kouemo Motse Francine Dorgelesse , Eboumbou Moukoko Carole Else , Kamgain Mawabo Lugarde , Pande Veena , Singh Vineeta 
Published: December 2022

Abstract
Background
There are growing reports on the prevalence of non-falciparum species and submicroscopic infections in sub-Saharan African countries but little information is available from Cameroon.

Methods
A hospital-based cross-sectional study was carried out in four towns (Douala, Maroua, Mayo-Oulo, and Pette) from three malaria epidemiological strata (Forest, Sahelian, and Soudanian) of Cameroon. Malaria parasites were detected by Giemsa light microscopy and polymerase chain reaction (PCR) assay. Non-falciparum isolates were characterized and their 18S gene sequences were BLASTed for confirmatory diagnosis.

Results
PCR assay detected malaria parasites in 82.4% (98/119) patients, among them 12.2% (12/98) were asymptomatic cases. Three Plasmodium species viz. P.falciparum, P.ovalecurtisi and P.vivax, and two co-infection types (P.falciparum + P.vivax and P.falciparum + P.ovalecurtisi) were found. The remaining infections were mono–infections with either P.falciparum or P.ovalecurtisi. All non–falciparum infections were symptomatic and microscopic. The overall proportion of submicroscopic infections was 11.8% (14/119). Most asymptomatic and submicroscopic infection cases were self-medicated with antimalarial drugs and/or medicinal plants. On analysis, P.ovalecurtisi sequences were found to be phylogenetically closer to sequences from India while P.vivax isolates appeared closer to those from Nigeria, India, and Cameroon. No G6PD-d case was found among non-falciparum infections.

Conclusions
This study confirms our previous work on circulation of P.vivax and P.ovalecurtisi and the absence of P.knowlesi in Cameroon. More studies are needed to address non-falciparum malaria along with submicroscopic infections for effective malaria management and control in Cameroon.
Early prediction of pathological complete response to neoadjuvant chemotherapy combining DCE-MRI and apparent diffusion coefficient values in breast Cancer
Authors: Liang Xinhong , Chen Xiaofeng , Yang Zhiqi , Liao Yuting , Wang Mengzhu , Li Yulin , Fan Weixiong , Dai Zhuozhi , Zhang Yunuo 
Published: December 2022

Abstract
Introduction
Improving the early prediction of neoadjuvant chemotherapy (NAC) efficacy in breast cancer can lead to an improved prediction of the final prognosis of patients, which would be useful for promoting individualized treatment. This study aimed to explore the value of the combination of dynamic contrast-enhanced (DCE)-MRI parameters and apparent diffusion coefficient (ADC) values in the early prediction of pathological complete response (pCR) to NAC for breast cancer.

Methods
A total of 119 (range, 28−69 years) patients with biopsy-proven breast cancer who received two cycles of NAC before breast surgery were retrospectively enrolled from our hospital database. Patients were divided into pCR and non pCR groups according to their pathological responses; a total of 24 patients achieved pCR, while 95 did not. The quantitative (Ktrans; Kep; Ve; IAUC) and semiquantitative parameters (W-in; W-out; TTP) of DCE-MRI that were significantly different between groups were combined with ADC values to explore their value in the early prediction of pCR to NAC for breast cancer. The independent T test was performed to compare the differences in DCE-MRI parameters and ADC values between the two groups. Receiver operating characteristic (ROC) curves were plotted, and the area under the ROC curve (AUC), sensitivity and specificity were calculated to evaluate the performance of the prediction.

Results
The Ktrans, Kep, IAUC, ADC, W-in and TTP values were significantly different between the pCR and non pCR groups after NAC. The AUC (0.845) and specificity (95.79%) of the combined Ktrans, Kep, IAUC and ADC values were both higher than those of the individual parameters. The combination of W-in, TTP and ADC values had the highest AUC value (0.886) in predicting pCR, with a sensitivity and specificity of 87.5% and 82.11%, respectively.

Conclusions
The results suggested that the combination of ADC values and quantitative and semiquantitative DCE-MRI parameters, especially the combination of W-in, TTP, and ADC values, may improve the early prediction of pCR in breast cancer.
Eribulin normalizes pancreatic cancer-associated fibroblasts by simulating selected features of TGFβ inhibition
Authors: Luong Tiffany , Cukierman Edna 
Published: December 2022

Abstract
Background
Less than 11% of pancreatic cancer patients survive 5-years post-diagnosis. The unique biology of pancreatic cancer includes a significant expansion of its desmoplastic tumor microenvironment, wherein cancer-associated fibroblasts (CAFs) and their self-produced extracellular matrix are key components. CAF functions are both tumor-supportive and tumor-suppressive, while normal fibroblastic cells are solely tumor-suppressive. Knowing that CAF-eliminating drugs are ineffective and can accelerate cancer progression, therapies that “normalize” CAF function are highly pursued. Eribulin is a well-tolerated anti-microtubule drug used to treat a plethora of neoplasias, including advanced/metastatic cancers. Importantly, eribulin can inhibit epithelial to mesenchymal transition via a mechanism akin to blocking pathways induced by transforming growth factor-beta (TGFβ). Notably, canonical TGFβ signaling also plays a pivotal role in CAF activation, which is necessary for the development and maintenance of desmoplasia. Hence, we hypothesized that eribulin could modulate, and perhaps “normalize” CAF function.

Methods
To test this premise, we used a well-established in vivo-mimetic fibroblastic cell-derived extracellular matrix (CDM) system and gauged the effects of eribulin on human pancreatic CAFs and cancer cells. This pathophysiologic fibroblast/matrix functional unit was also used to query eribulin effects on CDM-regulated pancreatic cancer cell survival and invasive spread.

Results
Demonstrated that intact CAF CDMs modestly restricted eribulin from obstructing pancreatic cancer cell growth. Nonetheless, eribulin-treated CAFs generated CDMs that limited nutrient-deprived pancreatic cancer cell survival, similar to reported tumor-suppressive CDMs generated by TGFβ-deficient CAFs.

Conclusions
Data from this study support the central proposed premise suggesting that eribulin could be used as a CAF/matrix-normalizing drug.
Prevalence, predictors and consequences of gambling on Children in Ghana
Authors: Kyei-Gyamfi Sylvester , Coffie Daniel , Abiaw Michael Ofori , Hayford Patience , Martey Joseph Otchere , Kyei-Arthur Frank 
Published: December 2022

Abstract

Background
Gambling is illegal for children in Ghana. However, young people, including children, are increasingly engaged in gambling across the country. Gambling is harmful and poses developmental implications for the youth, including children. There are limited studies on child gambling in Ghana and other sub-Saharan African countries. This study examined the prevalence of gambling participation, predictors of gambling participation, and perceived harm of gambling on children.

Methods
A cross-sectional convergent parallel mixed methodology was used to study 5024 children aged 8 to 17 in the three ecological zones of Ghana. Binary logistic regression was used to examine the predictors of gambling participation while the qualitative data was analysed thematically.

Results
Overall, 3.1% of children aged 8 to 17 had ever engaged in gambling activities. Also, being a female (AOR = 0.210, Wald test = 34.413, 95% CI: 0.125–0.354), having attained primary education (AOR = 4.089, Wald test = 18.643, 95% CI: 2.158–7.749), doing paid work (AOR = 2.536, Wald test = 10.687, 95% CI: 1.452–4.430), having a friend who gambles (AOR = 1.587, Wald test = 4.343; 95% CI: 1.028–2.451), having access to radio (AOR = 1.658, Wald test = 6.694, 95% CI: 1.130–2.431) and having access to mobile phone (AOR = 0.590, Wald test = 6.737, 95% CI: 0.396–0.879) were predictors of gambling participation. Gambling is perceived as harmful by children since it is addictive, affects learning and class attendance, and makes them steal from their families to gamble.

Conclusions
This study demonstrated that socio-demographic characteristics (sex, age, educational attainment, ecological zone, persons taking care of children, living arrangement, engagement in paid work, radio access, mobile phone access) and gambling-related information (having friends who gamble) make children more susceptible to gambling. Researchers and policymakers should consider these socio-demographic characteristics and gambling-related information when designing interventions to curb gambling among children aged 8 to 17 in Ghana.