bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on VLF Method Forecasting of Satellite Navigation and Communication Environment
Authors: Li Bei , Niu Youtian , Zhao Xiukun , Wang Zhe , Yang Sai , Zheng Zhiyuan 
Published: November 2022

Abstract
Solar flares are the most violent outbursts that occur in localized regions of the solar atmosphere. They emit large amounts of X-rays and energetic particles. X-rays reaching the earth at the speed of light will disrupt the calm ionospheric environment, causing sudden ionospheric disturbance (SID), which will make the very low frequency (VLF) signal to sudden phase anomaly (SPA), lead to the positioning error of satellite navigation system and interfere with satellite communication. Energetic particles will arrive near the satellite orbit in 1–3 days, causing direct damage to the satellite. They may also cause geomagnetic storms after reaching the Earth. In this paper, we mainly study to monitor solar activity and calculate solar flare class through the phase variation of VLF signal by combining the theory of VLF waveguide mode in order to forecast the environment of satellite navigation and communication. In addition, it can also predict energetic particles and geomagnetic storms 1–3 days in advance according to the time and class of flare outbreak, so that the protective measures for satellite to operate safely could be taken in advance.
Polymorphisms and expression of MMPs-TIMPs genes associated with cerebral ischemic stroke in young patients with sickle cell anemia
Authors: Ó Kleyton Palmeira do , Freire Ana Karla da Silva , de Nóbrega Debora Nascimento , Souza Roberta dos Santos , Farias Isabela Cristina Cordeiro , Belmont Taciana Furtado de Mendonça , Silva Andreia Soares da , Arcanjo Gabriela da Silva , Araujo Aderson da Silva , Anjos Ana Cláudia Mendonça dos , de Araujo Antônio Roberto Lucena , Bezerra Marcos André Cavalcanti , de Moura Patricia Muniz Mendes Freire , Cavalcanti Maria do Socorro Mendonça , Vasconcelos Luydson Richardson Silva 
Published: November 2022

Abstract

Background
Sickle cell anemia (SCA) is a genetic disease with great clinical heterogeneity and few viable strategies for treatment; hydroxyurea (HU) is the only widely used drug. Thus, the study of single nucleotide polymorphisms (SNPs) and the gene expression of MMPs 1, 2, 9, 7 and TIMPs 1 and 2, which are involved in the regulation of extracellular matrix, inflammation, and neuropathies, may provide further insights into the pathophysiology of the disease and elucidate biomarkers and molecules as potential therapeutic targets for patients with SCA.
Methods and Results
We evaluated 251 young individuals with SCA from northeastern Brazil. The groups were divided according to vaso-occlusive crisis (VOC) and cerebrovascular disease (CVD), compared to control individuals. SNP detection and gene expression assays were performed by real-time PCR, TaqMan system®. Both the expression levels of MMP1 gene, and the SNP MMP1 -1607 1G/2G were associated with the risk of cerebral IS, and the expression of MMP1 was also associated with a higher frequency of VOC/year. Expression levels of MMP7, TIMP1, and TIMP2 were increased in patients conditioned to IS. The SNP 372T>C (rs4898) TIMP1 T alleles were more frequent in patients with >5 VOC events/year. The SNP rs17576 of MMP9 showed differences in gene expression levels; it was increased in the genotypes AG, and AG+GG.
Conclusion
The findings of this study, the SNPs, and expression provide initial support for understanding the role of MMPs-TIMPs in the pathophysiology of SCA in young patients.
Development of Seismic Microzonation Maps for Low to Moderate Seismicity Regions Using Microtremor Observation Data
Authors: Lee Jian Yee , Chow Tze Liang , Chong Fui Lip , Cheah Yi Ben , Lau Tze Liang 
Published: November 2022

Abstract

Microzonation in low to moderate seismicity regions is not extensively used due to a lack of attention given. Accordingly, the structures are not designed for earthquake loading. However, these countries are susceptible to earthquake threat caused by local and far field earthquakes. The far field effect of earthquakes from neighbouring countries can be felt in Penang Island, Malaysia, which is contrary to the perception that Malaysia is seismic free. This hazard serves as a reminder of the importance of seismic study, particularly in the light of the local geological conditions. This work presents the ground structure of Penang Island for seismic microzonation map development using a simpler and affordable method for low to moderate seismicity regions. Moreover, this study applies microtremor single point and array observation methods to estimate the ground structure of Penang Island. The estimated ground structures are validated using the available borelog data and the results show good agreement. The developed microzonation maps show that Penang Island has a ground structure with a predominant frequency ranging from 1.45 Hz to 7.4 Hz andVs,30in the range of 168 m/s to 468 m/s. The northeast (Georgetown) and western (Balik Pulau) regions of Penang Island show a low frequency andVs,30value, indicating that these areas have a soft ground structure. The study demonstrates a simple and affordable method that can be adopted by low to moderate seismicity countries to develop seismic microzonation maps.
Peripheral blood T cell modulation by omalizumab in chronic urticaria patients
Authors: López Cristina , Depreux Nathalie , Bielsa Isabel , Roger Albert , Quirant-Sánchez Bibiana , Basagaña Maria , Jurgens Yanina , Padró Clara , Miquel Sira , Martínez-Cáceres Eva , Teniente-Serra Aina 
Published: November 2022

Abstract

Background: Chronic spontaneous urticaria (CSU) is a highly prevalent and difficult to manage disease. One of the main treatments used in CSU is the monoclonal antibody omalizumab, which effect on the immune system is still unknown. The understanding of the mechanism of action of this biological drug along with the identification of potential biomarkers in these patients would be useful to a more personalized management of the disease.
Objective: To identify potential biomarkers of response in peripheral blood of patients with CSU under omalizumab treatment.
Methods: We analyzed 71 patients with CSU, 33 under omalizumab and 38 under non-immunomodulatory drugs and 50 healthy donors as controls. We collected demographic and analytical data such as inflammation markers, atopy and immunological parameters and recorded the Urticaria Activity Score 7 (UAS 7) questionnaire on the control of the disease. Flow cytometry immunophenotyping of T-cell subpopulations, indirect Basophil Activation Test (BAT) to detect anti-IgE antibodies and anti-thyroid antibodies were studied.
Results: A reduction in the UAS 7 questionnaire has been seen before and after omalizumab treatment. Regarding the immune profile, we observed a higher percentage of type Th1 and Th2 cell subpopulations in the treated group with omalizumab compared with the others control groups. Furthermore, an increasing trend on Th17 and Th1 lymphocytes, and some activated T lymphocyte populations such as CD4+HLA-DR+CD38+ was observed on patients under omalizumab treatment.
Conclusions: The findings from this study demonstrate the involvement of omalizumab on adaptive immunity in the pathogenesis of chronic urticaria.
Comparison between the NUTRIC score and modified NUTRIC score to predict hospital mortality in cardiac surgery patients: A retrospective study
Authors: Xu Jing , Luo Dandong , Chi Ruibin , Deng Jia , Fang Heng , Wu Qingrui , Xu Wang , Huang Jianyang , Chen Chunbo 
Published: November 2022

Abstract
Background
Nutritional status is essential for patients undergoing cardiac surgery (CS), and malnutrition is an independent risk factor for postoperative adverse outcomes. The Nutrition Risk in the Critically Ill (NUTRIC) and modified NUTRIC (mNUTRIC) scores are nutritional risk assessment tools specifically for patients in the intensive care unit (ICU). The objective of this study was to validate and compare the accuracy of the NUTRIC score and the mNUTRIC score in predicting hospital mortality in CS patients.
Methods
This retrospective study screened adult CS patients under cardiopulmonary bypass in the ICU of a tertiary university affiliated hospital in China from June 2020 to August 2022. The demographic data, laboratory variables, clinical outcomes and hospital mortality of these patients were recorded, and all data were compared according to the NUTRIC score and the mNUTRIC score criteria for high and low nutritional risk. The area under the receiver operating characteristic curve (AUC-ROC) was used to compare the predictive performance of these two nutrition scores for hospital mortality.
Results
A total of 259 eligible patients were finally screened for statistical analysis; 57 patients had high NUTRIC scores, and 82 patients had high mNUTRIC scores. In both scores, patients in the high nutritional risk group had a higher rate of renal replacement therapy, longer duration of mechanical ventilation and ICU stay, and higher hospital mortality than those in the low nutritional risk group (p < 0.001). The AUC-ROC of the NUTRIC score and the mNUTRIC score for predicting hospital mortality were 0.833 (95% CI: 0.754–0.911) and 0.827 (95% CI: 0.751–0.902), respectively. There was no significant difference in ROC curves between the two scores (p = 0.532).
Conclusions
Both the NUTRIC and mNUTRIC scores showed good predictive performance for hospital mortality in CS patients, and the NUTRIC score was not superior to the mNUTRIC score.
Pattern and determinants of overweight and obesity among adolescents
Authors: Chukwuemeka Uchechukwu Martha , Donatus Chiemezie Victor , Fabunmi Ayodeji Ayodele 
Published: November 2022

Abstract

Purpose Obesity is one of the major factors implicated in raising morbidity and mortality in adults as well as adolescents and children. Obesity is increasing worldwide and there is evidence that this increase has been faster among the developing countries. Thus, the need to determine the pattern and determinants of overweight and obesity among adolescents. Methods This was a cross-sectional study involving 400 adolescents aged 14.38 ± 2.11years from randomly selected secondary schools. Questionnaire, weight and height metre was used to collect data. Descriptive statistics of mean ± standard deviation, frequency counts and percentage were used to summarize participants’ variables. Inferential statistics of Pearson’s correlation, independent samples t-test, Chi-square and binary logistic regression were used in hypotheses testing with 0.05 alpha levels. Result Mean of Body mass index(BMI) and daily physical activity(PA) in the last one week were 23.14 ± 3.49kg/m2and 1.84 ± 0.37 respectively with a point prevalence of 0.2(20 per 100 adolescents). There was a significant difference in BMI pattern and PA (with t-value − 3.94 and 5.31) between adolescents from public and private schools. Activity of daily living related-PA was found to have a significant association with BMI (P-value = 0.001, r = -0.17) and patterns of overweight and obesity among secondary school students (χ2 = 44.61, p < 0.001). Four predictors (PA during school recreation period, weight, height, and School type), together classified students who were likely to be overweight/obese with variance Nagelkerke R2 = 93.3%. The total prediction success is 91.8%, with 99.3% and 92.6% of those not overweight/obese and those that were correctly classified respectively. Conclusion This study highlights PA during school recreation period, weight, height, and School types as determinants of overweight/obesity in adolescents and also high prevalence of overweight and obesity.
Title: Cohort profile update: Tehran Cardiometabolic Genetic Study, a path toward precision medicine
Authors: Daneshpour Maryam S , Akbarzadeh Mahdi , Lanjanian Hossein , Sedaghati-khayat Bahar , Guity Kamran , Masjoudi Sajedeh , Zahedi Asieh Sadat , Moazzam-Jazi Maryam , Bonab Leila Najd Hassan , Shalbafan Bita , Asgarian Sara , Farhood Goodarz Koli , Javanrooh Niloofar , Zarkesh Maryam , Riahi Parisa , Moghaddas Mohammad Reza , Dehkordi Parvaneh Arbab , Ahmadi Azar Delbarpour , Hosseini Firoozeh , Farahani Sara Jalali , Hadaegh Farzad , Mirmiarn Parvin , Tehrani Fahimeh Ramezani , Ghanbarian Arash , Pasand Mohammad Sadegh Fallah Mahboob , Amiri Parisa , Valizadeh Majid , Hosseipanah Farhad , Tohidi Maryam , Ghasemi Asghar , Vakili Azita Zadeh , Alamdari Shahram , Khalili Davood , Momenan Amirabbas , Barzin Maryam , Zeinali Sirous , Hedayati Mehdi , Azizi Fereidoun 
Published: November 2022

Abstract
The Tehran Cardiometabolic Genetic Study (TCGS) is a large population-based cohort study with periodic follow-ups, which created a comprehensive database of 20,367 participants born between 1911-2015 selected from 4 different longitudinal, ongoing, and family-based studies. The study aims to identify the potential targets for prevention and intervention for non-communicable diseases in mid-life and late life. The study focuses on cardiovascular, endocrine, metabolic abnormalities, cancers, and some inherited diseases. Since 2017, the cohort expanded the information by coding all health-related complications (hospitalization outcomes and self-reports) based on ICD11 coding and confirming the consanguineous marriage with genetic markers. This article presents an update on the rationale and design of the study. We also present a summary of our findings and our goals toward precision medicine.
Continuous Dyeing of Cellulose Electrospun Nanofibrous Mat with Synthetic Indigo Dyes
Authors: Khatri Awais , Ali Shamshad , Javeed Alishba 
Published: November 2022

Abstract
In our study, cellulose electrospun nanofibrous mats (ENMs) were dyed with synthetic indigo dyes by continuous method. We have used the industrial scale dyeing procedure (pre-wetting, dyeing and washing-off steps). The effect of pH, concentration of sodium hydrosulphite, dye bath temperature and concentration of indigo dyes on the color yield (K/S) were optimized. Excellent K/S of dyed cellulose ENMs were achieved (reached to 13) with good colorfastness properties. For comparison, aniline-free synthetic indigo dyes were applied on the cellulose ENMs. The dyeing effluent was measured for pH, TDS and COD results. Considerable ecological merits have been found for dyeing effluent of aniline-free synthetic indigo dyes in comparison to the synthetic indigo dyes. Furthermore, the dyed samples were characterized by SEM analysis, ATR-FTIR spectroscopy.
Effect of presentation rate on auditory processing in Rett Syndrome: ERP study
Authors: Kostanian Daria , Rebreikina Anna , Nekrashevich Maxim , Sharaev Maxim , Voinova Victoria , Sysoeva Olga 
Published: November 2022

Abstract

Rett Syndrome (RS) is a rare neurodevelopmeтtal disorder characterized by mutations in theMECP2gene. Patients with RS have severe motor abnormalities and are often unable to walk, use hands and speak. The preservation of perceptual and cognitive functions is hard to assess, while clinicians and care-givers point out that these patients need more time to process information than typically developing peers. Here we examine neurophysiological correlates of auditory processing in RS as a function of presentation rate. From previous literature we knew that auditory event-related potential (ERP) is increased with prolongation of interstimulus interval (ISI). We presented a repetitive stimulus (1000Hz) at three different ISI of 900 ms, 1800 ms, and 3600 ms in children with RS and their typical development peers (TD) aged 2.5–16 years while recording 28-channels electroencephalogram, EEG. The amplitude of N1 and P2 components of event-related potential (ERP) was smaller at ISI 900 than at longer ISIs in both groups, pointing out that the basic mechanism of adaptation in the auditory system is preserved in Rett Syndrome. At the same time the latency of these components was significantly delayed in the RS than in TD. Moreover, late components (P2 and N2) were drastically reduced in Rett Syndrome irrespective of the ISI, suggesting a severely affected mechanism of integration of upcoming sensory input with memory. Based on these ERP measures it was possible to differentiate RS from TD with great accuracy (0.922 ± 0.047), being maximal with shortest ISI, supporting its implication as potential output measures in clinical trials as well as pointing to the diminishing of the neurophysiological differences between RS and TD with slowing down the presentation rate.
Energy and Performance Centric Resource Allocation Framework in Virtual Machine Consolidation using Reinforcement Learning Approach
Authors: Brahmam Madala Guru , R Vijay Anand 
Published: November 2022

Abstract
Virtual machines are deployed to ease the performance, management overhead and access regularities of applications on cloud platforms. Virtual machines are often susceptible to overloading burdens, delays and other hurdles during server consolidation and migration processes. In order to regulate the energy dissipation, monitor the overloading and under loading issues, dynamic consolidation processes are introduced to distribute loads across virtual machines substantially. Consolidation process demands additional computations and resources to reallocate the services from one virtual machine to another, subjected to adherence of Service Level Agreements. The proposed methodology advocates the implementation of a novel architecture for consolidating virtual machines and thus balance the energy and performance parameters. Overall resource requirements, Performance to Power Ratio (PPR) are primary factors in design of proposed Dynamic Weightage algorithm, including the clustering approach with respect to reinforcement learning techniques. Cluster of optimal virtual machines are formed, resources are allocated based on optimal energy and performance expectations. Resource requests from virtual machines are derived into a matching relationship factor to represent the respective hosts with PPR considerations. These estimations also deliver the overall workload incurred during virtual machine consolidation. It is observed that the performance throughout the cluster is maintained to be a nominal with minimal trade-off to energy. The architecture is implemented over an offline platform, which are distributed environments, enabling scalability and improved efficiency of the entire system. The system is validated on CloudSim simulator with datasets retrieved from PlanetLab. From the results obtained, it is noted that energy conservation has yielded up to 47%, with promising quality of service parameters. Results are compared with other state of art algorithms for distributed architectures and heterogeneous environments to prove the efficiency of the system.
Relationship between monocular form deprivation amblyopia and activity-regulated cytoskeleton-associated in visual cortex of kittens
Authors: Fan Haobo , Wang Ying , Zou Yunchun , Song Weiqi , Chen Siyu , Tang Xiuping , Xie Juan 
Published: November 2022

Abstract
Purpose
Exploring the role of activity-regulated cytoskeleton-associated (Arc) in visual cortex in visual development, and studying its expression changes in amblyopia kittens.
Methods
Fifteen 3-week-old kittens were randomly selected from the deprivation group and the control group, and raised in the natural environment. Black opaque covering cloth was used to cover the right eye of deprived kittens. Pattern visual evoked potentials (PVEP) was detected at the 3rd, 4th, 6th and 8th weeks of age, and 5 kittens were randomly selected from each group and euthanized after each detection. The Arc expression both at mRNA and protein levels was assessed using in situ hybridization and immunohistochemistry analyses. Apoptosis of visual cortex cells in 8-week-old kittens was detected by TUNEL.
Results
With the increase of age, the expression of Arc gene in visual cortex of both the deprivation group and the control group showed an upward trend, but the upward trend of the control group was more obvious. At the age of 8 weeks, the expression of Arc protein (P < 0.05) and mRNA (P < 0.05) in visual cortex of deprived kittens was lower than that of control kittens. Moreover, the number of apoptosis in visual cortex of deprivation group was higher than that of control group (P < 0.05). Correlation analysis shows that the expression of Arc gene was negatively correlated with the apoptosis level of visual cortex neurons.
Conclusions
The expression of Arc is associated with monocular form deprivation amblyopia and affects the apoptosis of visual cortex cells.
Vibrio cholerae O1 associated with recent endemic cholera shows temporal changes in serotype, genotype, and drug-resistance patterns in Bangladesh
Authors: Jubyda Fatema Tuz , Nahar Kazi Sumaita , Barman Indrajeet , Johura Fatema-Tuz , Islam Mohammad Tarequl , Sultana Marzia , Ullah Wali , Tasnim Jarin , Biswas Sahitya Ranjan , George Christine Marie , Camilli Andrew , Ahmed Niyaz , Ross Allen G. , Clemens John D. , Alam Munirul 
Published: November 2022

Abstract

Background
Despite the advancement in our understanding of cholera and its etiological agent, V. cholerae, the prevention and treatment of the disease are often hindered due to rapid changes in drug response pattern, serotype, and the major genomic islands namely, the cholera toxin phage, and related genetic characteristics. In the present study, V. cholerae (n = 172) associated with endemic cholera in Dhaka during the years 2015–2021 were analyzed for major phenotypic and genetic characteristics, including drug resistance patterns.
Results
Results revealed that the V. cholerae strains belonged to serogroup O1 biotype El Tor carrying El Tor -specific genes rtxC, tcpA El Tor, and hlyA El Tor, but possessed classical-biotype cholera toxin. Serotypes of V. cholerae strains differed temporally in predominance with Inaba during 2015–2017, and again in 2020–2021, while Ogawa was the predominant serotype in 2018–2019. Also, ctxB1 was predominant in V. cholerae associated with cholera during 2015–2017, while ctxB7 was predominant in 2018, and in the subsequent years, as observed until 2021. V. cholerae strains differed in their antibiotic resistance pattern with a majority (97%) being multi-drug resistant (MDR) and belonging to eight sub-groups. Notably, one of these MDR strains was resistant to eleven of the eighteen antibiotics tested, with resistance to fourth-generation cephalosporin (cefepime), and aztreonam. This extreme drug resistant (XDR) strain carried resistance-related genes namely, extended-spectrum β-lactamases (ESBL), blaOXA-1 and blaPER-3.
Conclusion
The observed temporal switching of serotypes, as well as the ctxB genotype, and the emergence of MDR/XDR V. cholerae and their association with endemic cholera in Dhaka underscore the need for routine monitoring of the pathogen for proper patient management.