bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personality traits and insomnia: direct and anxiety‐mediated associations
Authors: Conway Bárbara Araújo , do Carmo Marwin Machay Indio do Brasil , Filho Helder Sergio Lira Soares , Toscanini Andrea Cecília , Hasan Rosa , Alves Marcela Mansur , El Rafihi‐Ferreira Renatha 
Published: February 2025

SummaryInsomnia is the one of the most prevalent sleep disorders in the adult population. Studies have shown that personality traits, particularly neuroticism, act as factors that predispose to and potentially perpetuate insomnia; however, there is still no consensus in the literature regarding these relationships considering their mechanisms. A total of 595 participants answered the Insomnia Severity Index, Revised Neuroticism‐Extroversion‐Openness (NEO) Five‐Factor Inventory, Hospital Anxiety and Depression Scale, questions of the Diagnostic and Statistical Manual of Mental Disorders (fifth edition), and a sociodemographic questionnaire. Descriptive analysis, correlations and stepwise linear regression were used to assess the associations between the five personality traits and insomnia severity. Mediation and moderation analyses were performed to evaluate the mechanisms underlying the association between insomnia severity and neuroticism. There was a direct negative association between insomnia severity and openness to experience and an indirect positive association between insomnia severity and neuroticism. Anxiety was identified as a mediator and depression as a moderator of the association between insomnia severity and neuroticism. The neuroticism and openness to experience personality traits are significant predictors of insomnia severity. Openness to experience appears to be a protective factor against insomnia. Longitudinal studies are needed to confirm our findings. These results may contribute to the development of new psychological and behavioural protocols for the treatment of insomnia.
Single‐Cell Transcriptome Identifies a Proinflammatory B‐Cell Subset in Hepatitis B Virus Associated Acute‐on‐Chronic Liver Failure
Authors: Wang Han , Xu Chuanshen , Yao Ruoyu , Zhang Wenrui , Wang Shuang , Qin Xiaojing , Liu Qi , Zhao Ninghui , Sun Peng , Yao Jia 
Published: February 2025

ABSTRACTAcute‐on‐chronic liver failure (ACLF) is a severe clinical condition with high short‐term mortality, in part due to the dysfunctional immune response. Identifying immune mechanism under ACLF is critical to understand its pathogenesis and to develop novel targeted therapeutics. Among the immune cells, how are B cells involved in ACLF remains largely unknown. We performed scRNA‐seq on peripheral blood mononuclear cells from clinical ACLF patients and healthy controls. Integrated analysis was performed to identify the role of B cells in ACLF. Subsequently, different subsets of B cells in ACLF were validated through flow cytometry based on their highlighted markers. Six B‐cell subgroups, including naive B cells, naive B2 cells, nonclass‐switched memory B cells, class‐switched memory B cells, autoimmune‐related B cells and plasma B cells were identified. The proportions of naive B cells significantly expand in ACLF, compared with healthy control. Function enrichment analysis revealed the activation of inflammatory response in naive B cells. Further flow cytometry confirmed the elevated circulating naive B cells in ACLF. Our study uncovered the altered immune landscape of circulating B cells after ACLF. The proportion dynamics and functional perturbation indicate the potential of naive B cells as intervention targets in the future ACLF therapy.
Bocavirus Infection as a Potential Trigger for Hepatic Injury in Children
Authors: Seyrek Bera Enes , Aykac Kubra , Temizel İncinur Saltık , Cengiz Ali Bülent , Ozsurekci Yasemin 
Published: February 2025

ABSTRACTHuman Bocavirus (HBoV) is an emerging pathogen linked to respiratory and gastrointestinal infections in children. While its role in respiratory diseases is established, its association with liver dysfunction remains unclear. This study presents six paediatric cases of elevated liver enzymes or acute liver failure during HBoV infection, including severe outcomes such as liver transplantation and one fatality. Frequent co‐infections with other pathogens were noted, complicating the clinical course. Although direct evidence of HBoV's role in liver involvement is lacking, its potential contribution warrants further investigation to guide clinical management.
Screening, Prevalence and Management of Chronic Viral Hepatitis C in Mental Health Setting: Towards the Eradication of A Forgotten Reservoir
Authors: Chelouah Sonia , Nna Harmonie , Angijiro Paul , Thomas Fanny , Thavaseelan Rusheenthira , Januel Dominique , Yekhlef Wanda 
Published: February 2025

ABSTRACTThe rate of HCV infection is higher in people with psychiatric conditions than in the general population. However, access to somatic care for populations with mental or dual diagnoses remains insufficient. These circumstances could constitute a barrier to the eradication of HCV infection. A retrospective study was performed in the public mental health institution of Ville Evrard. Screening for HCV infection should be systematically proposed to patients attending the institution. On‐site assessment of liver disease severity and treatment with direct‐acting antivirals prescribed by physicians not specialised in hepatology allowed a better continuum of care. Patients lost to follow‐up after a positive HCV serology test without viral load assessment were contacted. Patients hospitalised at least once a year were included. 8520 patients out of 18,439 (46.2%) were screened for HCV infection between 2017 and 2021. The screening rate increased from 40.0% in 2017 to 65.7% in 2021. HCV seroprevalence was 2.2%. A total of 129 HCV PCRs were performed, and 27.1% were positive. In a logistic regression model, patients older than 30 years were at greater risk of having a positive HCV serology test. These positive serologies were 1.9 times higher in men than women (p < 0.001). The assessment of fibrosis was found in 45.7% of patients with a positive HCV PCR. Patients with psychiatric conditions constitute an important HCV reservoir. A strategy of screening and management of HCV infection in this population appears to be feasible. This strategy could contribute to the eradication of chronic HCV infection.
Digit Length Ratio as an Indicator of Fetal Androgen Levels: Relationship to Prostate Volume‐Related Men Lower Urinary Tract Symptoms
Authors: Ergin İsmail Emre , Öztürk Abuzer , Asdemir Aydemir 
Published: February 2025

ABSTRACTObjectiveThis study aimed to investigate the relationship between the 2nd and 4th digit ratios, which are associated with fetal androgen exposure, and prostate volume and testosterone levels, both of which are linked to lower urinary tract symptoms (LUTS).MethodsMale patients presenting to our urology clinic with increased prostate volume and LUTS were categorized into two groups: those with BPH and those without (non‐BPH). For both groups, the right‐hand 2D:4D finger ratio, testosterone levels, prostate volume, uroflow parameters, and IPSS scores were recorded.ResultsThe 2D:4D ratio, prostate volumes, Qmax, and IPSS scores differed significantly between the BPH and non‐BPH groups (p = 0.023, 0.002, 0.000, 0.001). No significant difference was observed in total testosterone levels between the groups (p = 0.381). The 2D:4D ratio was negatively correlated with prostate volume and IPSS (r = −0.389, −0.308) and positively correlated with Qmax (r = 0.301).ConclusionsOur study demonstrates that the 2D:4D ratio is a straightforward and effective tool for assessing BPH patients, as it correlates with the severity of LUTS symptoms. This non‐invasive measure offers potential value in evaluating LUTS, and with age standardization, it could be applied more broadly across age groups. Further large‐scale studies are needed to refine its standardization and expand upon current findings.
Delay Solow Model Revisited
Authors: Matsumoto Akio , Szidarovszky Ferenc 
Published: February 2025

ABSTRACTThis paper shows how cyclic behavior can emerge in a simple Solow capital accumulation model. For this purpose, it introduces a production delay (i.e., time‐to‐build) and a depreciation delay, and the resultant capital accumulation equation is a delay differential equation having delay‐dependent coefficients. Then, it constructs a condition under which the interaction of the delays and the population growth rate can lead to growth cycles that are not unlike those observed in reality. In particular, it is demonstrated that (i) the production delay alone is always harmless; (ii) with a lower population growth rate, the depreciation delay alone has a destabilizing effect if it is larger than a threshold value; (iii) with a larger population growth rate, the stable steady state arises regardless of the delay length. It is further demonstrated that multiple stability switchings can occur in the case of two distinct delays.
Safety and Sustainability of Axillary Versus Radial Arterial Catheters in Critically Ill Children: A Retrospective Comparative Study
Authors: Davidovich Rotem , Kaplan Eytan , Kadmon Gili , Nahum Elhanan , Weissbach Avichai 
Published: February 2025

ABSTRACTBackgroundArterial catheters are commonly used for hemodynamic monitoring and blood sampling in critically ill children, with the radial artery being the typical site. When radial cannulation is not feasible, alternative sites like the axillary artery may be utilized. However, the safety and sustainability of axillary arterial catheters compared to radial catheters in this population remain unclear.AimsThis study aims to assess the safety and sustainability of axillary arterial catheters compared to radial arterial catheters in pediatric intensive care unit patients.MethodsWe conducted a retrospective, case–control study at a university‐affiliated tertiary care pediatric intensive care unit. Patients aged 18 years or younger with axillary arterial catheters from January 2007 to December 2023 were compared to patients of similar ages with radial catheters.ResultsA computerized chart review identified 306 patients with axillary catheters, compared to 306 randomly selected patients with radial catheters. The rate of catheter site replacement was identical in both groups (40 out of 306). The median duration of axillary catheter use was 34 h longer (95% CI: 24–48; p < 0.001). Only one patient in the axillary group (0.33%) experienced a vascular complication, recovering fully after intervention. Patients with axillary catheters were characterized by a higher Pediatric Index of Mortality 3 scores, Vasoactive‐Inotropic Scores, and PICU mortality rates.ConclusionsIn this critically ill pediatric cohort, axillary arterial catheters were used longer and in a more severely ill population than radial catheters. Despite these differences, both catheter types demonstrated comparable safety and sustainability profiles.
A system genetics analysis uncovers the regulatory variants controlling drought response in wheat
Authors: Chen Bin , Liu Yuling , Yang Yanyan , Wang Qiannan , Li Shumin , Li Fangfang , Du Linying , Zhang Peiyin , Wang Xuemin , Zhang Shuangxing , Zhang Xiaoke , Kang Zhensheng , Wang Xiaojie , Mao Hude 
Published: February 2025

SummaryPlants activate a variable response to drought stress by modulating transcription of key genes. However, our knowledge of genetic variations governing gene expression in response to drought stress remains limited in natural germplasm. Here, we performed a comprehensive analysis of the transcriptional variability of 200 wheat accessions in response to drought stress by using a systems genetics approach integrating pan‐transcriptome, co‐expression networks, transcriptome‐wide association study (TWAS), and expression quantitative trait loci (eQTLs) mapping. We identified 1621 genes and eight co‐expression modules significantly correlated with wheat drought tolerance. We also defined 620 664 and 654 798 independent eQTLs associated with the expression of 17 429 and 18 080 eGenes under normal and drought stress conditions. Focusing on dynamic regulatory variants, we further identified 572 eQTL hotspots and constructed transcription factors governed drought‐responsive network by the XGBoost model. Subsequently, by combining with genome‐wide association study (GWAS), we uncovered a 369‐bp insertion variant in the TaKCS3 promoter containing multiple cis‐regulatory elements recognized by eQTL hotspot‐associated transcription factors that enhance its transcription. Further functional analysis indicated that elevating TaKCS3 expression affects cuticular wax composition to reduce water loss during drought stress, and thereby increase drought tolerance. This study sheds light on the genome‐wide genetic variants that influence dynamic transcriptional changes during drought stress and provides a valuable resource for the mining of drought‐tolerant genes in the future.
Migration discourses from the radical right: Mapping and testing potential for political mobilization
Authors: Veri Francesco , Maier Franziska 
Published: February 2025

AbstractRadical right‐wing groups are often linked to conspiratorial beliefs that can fuel political extremism but understanding how these beliefs translate into real‐world action remains a challenge, as these communities tend to operate in insular networks. This study examines how migration‐related narratives shape political behaviour among Italy’s radical right. Using Facebook’s advertising system, we recruited supporters of these movements for an experimental survey. Applying Cultural Consensus Theory (CCT), we measured group consensus on anti‐migrant beliefs and tested the impact of media exposure by presenting participants with either positive or negative portrayals of migrants. Our findings reveal two key insights. First, radical right‐wing communities exhibit deeply entrenched anti‐migrant beliefs that function as cultural truths and are resistant to shifts in media framing. Second, negative media exposure does however amplify support for hostile political actions, including protests and political violence. Conversely, positive portrayals reduce the coherence of anti‐migrant consensus but do not significantly lower preferences for confrontational actions. These results suggest that media exposure does not change the core extremist beliefs of radical right‐wing supporters but instead triggers emotional responses that shape political behavior. Specifically, negative portrayals of migrants increase support for direct actions, such as protests and political violence, even though they do not reinforce or strengthen consensus on anti‐migrant beliefs. This finding underscores that countering violent extremism requires more than just challenging harmful narratives—it also demands addressing the emotional triggers that translate these attitudes into mobilization and political action.
Is Warmth More Persuasive? The Effects of Street‐Level Bureaucrats' Warmth and Competence on Citizens' Compliance During Pandemic Emergencies
Authors: Pei Zhijun 
Published: February 2025

ABSTRACTCompliance with government rules and guidelines is essential for effectively managing pandemic emergencies. Few studies have examined how street‐level bureaucrats (SLBs)' behavioral performance shapes citizen compliance decisions. This study combines the stereotype content model (SCM) with the elaboration likelihood model (ELM) of persuasion in a large‐scale randomized between‐subjects survey experiment conducted in China. The study tests the hypothesis that citizens' impressions of warmth and competence toward SLBs have respective and interactive positive persuasive effects on their compliance with government rules and guidelines during a pandemic emergency. The study finds that the impressions of competence and warmth are always important for citizen compliance in a pandemic emergency; and the impression of warmth matters more for citizen compliance for competent bureaucrats. An interaction effect between impressions of SLBs' warmth and competence in predicting citizen compliance was also confirmed. Citizens are more inclined to comply when they perceive SLBs as both competent and warm. The study concludes that citizens' compliance with government rules and guidelines during a pandemic emergency partly depends on their impressions of the quality of bureaucratic encounters. Thus, probing and highlighting citizens' impressions of SLBs during citizen–bureaucratic interactions is theoretically and practically worthwhile.
The evolution of mandated coordination in policy implementation: Evidence from China's central government agencies
Authors: Ma Liang , Chen Bin , Christensen Tom , Liu Weixing 
Published: February 2025

AbstractPolicies are often mandated to be implemented by multiple agencies, and it is meaningful to explore the mechanisms and dynamics of interagency coordination. By employing structurally oriented theory from organization theory to analyze archival data, this study examines the structure and dynamics of mandated interagency coordination arrangements in China's central agencies (2005–2022). Given their intricacies, economic and social policies are the priorities of mandated coordination. The results show a dense and unbalanced coordination, in which powerful agencies dominate coordination. The results reveal that coordination across agencies has steadily increased over time despite intensive institutional mergers and consolidation.
A pattern of hybridisation and population genetic structure of two water frog species (Ranidae, Amphibia) in the southwestern Balkans
Authors: Papežík Petr , Aschengeschwandtnerová Sandra , Benovics Michal , Dedukh Dmitrij , Doležálková‐Kaštánková Marie , Choleva Lukáš , Javorčík Adam , Lymberakis Petros , Papežíková Simona , Poulakakis Nikos , Sarı İdris , Šanda Radek , Vukić Jasna , Mikulíček Peter 
Published: February 2025

AbstractThe distribution of the neutral component of genetic diversity is the interplay of historical and ongoing processes resulting in the species‐specific genetic structure of populations, which can, however, be disrupted by interspecific hybridisation and introgression. In this study, we focused on two species of water frogs, Pelophylax epeiroticus and P. kurtmuelleri, which live in sympatry in the southwestern Balkans, to investigate the rate of hybridisation and population genetic structure using cytogenetic, mitochondrial (ND2) and nuclear DNA (microsatellite) markers. The overall hybridisation rate was 2.6%, with rates reaching up to 10% at specific sites. The course of gametogenesis and the occurrence of later generations of hybrids (beyond the F1 generation) indicate a sexual mode of hybrid reproduction. The bimodal structure of hybrid populations and the rarity of hybrids suggest substantial reproductive isolation between the two species; however, this isolation is unlikely attributable to differences in ecological niche occupation. In P. epeiroticus, sequence variation in the ND2 gene revealed two divergent lineages with a clear geographic pattern that corresponds to the genetic structure in microsatellite markers. In contrast, P. kurtmuelleri populations were not as geographically structured and showed only weak genetic differentiation in both types of markers. Pelophylax epeiroticus was significantly less variable at microsatellite loci compared to P. kurtmuelleri, which, together with the high differentiation of its populations, suggests a stronger influence of genetic drift. We can hypothesise that the differential strength of genetic drift in the two species may lead to unequal interspecific gene flow.
The Benefits of Research-Embedded Training Camps in Sport Sciences
Authors: Girard Olivier , Brocherie Franck 
Published: February 2025

Background: Sport scientists aim to enhance athletic performance by developing, implementing, and evaluating evidence-based strategies. However, a common challenge to maximize sport science’s impact is the limited involvement of “research end users” (ie, athletes, coaches, and practitioners) in contextualizing these strategies. To address this, research-embedded training camps (RETCs) offer a collaborative opportunity bringing together all stakeholders to tackle real-world challenges by blending scientific insight with practical application for better knowledge translation or production. Purpose: This invited commentary explores the behind-the-scenes aspects of conducting successful RETCs. We discuss opportunities and challenges involved, drawing on our practical experience with environmental stress interventions. Evidence: Implementing an RETC requires a tailored intervention, shaped by the athlete group, research questions, and available resources—essentially answering the who, what, why, when, and where questions. Key principles for success include an athlete-centered focus, a diverse multidisciplinary team, scientific rigor, balancing control with flexibility, and adaptability. A coconstructed design ensures that the intervention remains scientifically relevant and practical and directly addresses real-world needs of athletes. Conclusion: Through the lens of environmental stress interventions, RETCs should prioritize practicality, collaboration, and athlete-focused approaches. Conducting interventions with athletes rather than on them can significantly enhance performance and support evidence-based training strategies (knowledge translation) and/or provide new actionable insights (knowledge production).
A Survey-Based Evaluation of Resistance Training Prescription Practices, Knowledge, and Attitudes Among Family Physicians
Authors: Herstain Daniel , Silverman Yedidya , Baruch Shoham , Green Ilan , Obolski Uri , Halperin Israel 
Published: February 2025

Background: Despite the well-established benefits of resistance training (RT) in reducing health risks and enhancing quality of life, adherence to RT guidelines remains low. Promoting RT through healthcare practitioners could facilitate its widespread adoption. Although numerous studies have examined healthcare practitioners’ knowledge and prescription practices of physical activity, few have specifically focused on RT. Methods: Prescription practices and barriers, knowledge and attitudes toward RT, and attitudes toward RT education were assessed from a convenience sample recruited by a multichannel approach (eg, social media and mailing lists). Physicians answered an online questionnaire composed of 32 questions developed by a multidisciplinary team. A convenience sample was recruited through social media and mailing lists. Results: A total of 158 family physicians practicing in Israel completed the questionnaire. RT prescription rates were low, ranging from 16.9% to 31.9%, depending on the estimation method. Self-reported barriers to RT prescription included insufficient knowledge about RT and how to prescribe it. Physicians showed limited knowledge of RT guidelines but generally viewed RT positively for various health conditions. Finally, 83.5% felt inadequately trained in RT, and 88.6% expressed a desire for further education. Conclusions: This study highlights a gap between the recognized benefits of RT and the prescription practices and knowledge of family physicians. Enhanced educational efforts targeting RT could bridge this gap, potentially increasing RT prescription rates and improving public health outcomes.