bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of network administrative organizations in governing interjurisdictional natural resources
Authors: Liu Yixin , Tan Chao 
Published: January 2022

AbstractCan network administrative organizations (NAOs) improve networks' ability to solve complex social and environmental problems? This is a classical question in collaborative governance. The public management literature examines collaborative outcomes at either the organization or the entire network level, but has not addressed “edge level” outcomes to evaluate structured interactions among network actors. Therefore, we investigate outcomes in an interjurisdictional area that reflect collaborative efforts between local governments. Recently, Guangdong Province in China enacted the River Chief System, an institutional reform that mandates the provincial government to establish an NAO to coordinate intercity rivers' management. To assess how well the reform has worked to reduce pollution, we employ the synthetic control method using monthly water quality data from 14 river monitoring sites in two neighboring cities. Our results indicate that the reform reduced the interjurisdictional river sites' pollution level effectively by 36% in the following year. This preliminary finding contributes to the collaborative governance theory and provides new evidence on whether the NAO model improves the shared outcomes between local governments.
Why is rice Amax (at saturating CO2) more heritable than Asat (at ambient CO2)? A commentary on Acevedo‐Siaca et al. (2021)
Authors: Fabre Denis , Dingkuhn Michael 
Published: January 2022

AbstractAcevedo‐Siaca et al. (2021) reported that Amax (at saturating CO2) is more heritable than Asat (at ambient CO2) in rice and suggested the former to be selected to improve photosynthesis under rising ambient [CO2] levels. This commentary hypothesizes sink limitation to be a factor contributing to low genotypic Amax via feedback inhibition (acclimation) of photosynthesis as observed under elevated [CO2]. This process may to some extent also happen under current ambient [CO2]. If confirmed, future breeding for greater photosynthesis should seek improving carbon sink traits as opposed to (or in addition to) modifying the photosynthetic apparatus, which is more difficult.
Meeting the COVID‐19 moment: Peace analysis within the Latin American Council for Peace Research (CLAIP) 1977–2021
Authors: Oswald‐Spring Úrsula 
Published: January 2022

AbstractThis article analyzes the foundation of the Latin America Council of Peace Research (CLAIP in Spanish) in 1977 within the complex geopolitical conditions of military coups, lack of democracy, political refugees, Operation Condor, and economic crises. Globally, the geopolitical environment was equally complex with the Vietnam War, Watergate scandal, the School of the America's training militaries in torture, and the rise of the Taliban from the Soviet conflict in Afghanistan. In these adverse conditions, peace research and negotiation of conflicts were crucial. CLAIP developed to meet these needs over a five‐phase process of consolidation: 1. Foundational; 2. Expansion toward whole Latin America; 3. Fragmentation and specialization of peace research; 4. Development of hybrid and amalgam peace theories, and 5. The emergence of different regional approaches focusing also on gender perspective. This convergence has yielded more holistic paradigms that address the multifaceted threats to positive peace posed by the global response to COVID‐19. The article explores the potential for an integrated human, gender, and environmental, an engendered peace paradigm—called the HUGE model—to guarantee even the most marginalized women and girls a peaceful and secure future development in the subcontinent—even in the aftermath of the pandemic.
Protein‐Mediated Fluorescence Resonance Energy Transfer (P‐FRET) Probe: Fabrication and Hydroxyl Radical Detection†
Authors: Yu Xiaokan , Zhu Weisheng , Ouyang Wenao , Zhang Xiaojia , Qiu Hao , Zhang Zhijun , Xing Bengang 
Published: January 2022

AbstractFluorescent probes based on fluorescence resonance energy transfer (FRET) are highly promising for diverse bioapplications. The key to constructing FRET probes is to confine the donor and acceptor within a sufficiently close distance. However, the commonly used covalent linkage often requires elaborate design and complex organic synthesis, and sometimes causes changes in the fluorescence properties of the donor and acceptor. Inspired by the binding between small molecules and protein in nature, herein, we propose a protein‐mediated strategy to fabricate FRET probe. In such protein‐mediated FRET (P‐FRET) probe, protein acts as a carrier to simultaneously confine donor and acceptor in its cavity. As a proof of concept, we use bovine serum albumin (BSA) as a model protein, coumarin derivative as a donor and hydroxyl radical (·OH)‐responsive dye fluorescein as an acceptor. Through a series of investigations, including binding parameters, fluorescence properties and detection performance, we prove that the construction of P‐FRET probe is simple and feasible and the detection is sensitive. Our P‐FRET strategy will provide new insights for the design of FRET probes.
Quantile Mixed Hidden Markov Models for Multivariate Longitudinal Data: An Application to Children's Strengths and Difficulties Questionnaire Scores
Authors: Merlo Luca , Petrella Lea , Tzavidis Nikos 
Published: January 2022

AbstractThe identification of factors associated with mental and behavioural disorders in early childhood is critical both for psychopathology research and the support of primary health care practices. Motivated by the Millennium Cohort Study, in this paper we study the effect of a comprehensive set of covariates on children's emotional and behavioural trajectories in England. To this end, we develop a quantile mixed hidden Markov model for joint estimation of multiple quantiles in a linear regression setting for multivariate longitudinal data. The novelty of the proposed approach is based on the multivariate asymmetric Laplace distribution which allows to jointly estimate the quantiles of the univariate conditional distributions of a multivariate response, accounting for possible correlation between the outcomes. Sources of unobserved heterogeneity and serial dependency due to repeated measures are modelled through the introduction of individual-specific, time-constant random coefficients and time-varying parameters evolving over time with a Markovian structure respectively. The inferential approach is carried out through the construction of a suitable expectation–maximization algorithm without parametric assumptions on the random effects distribution.
Donor‐derived tuberculosis among solid organ transplant recipients in the United States—2008 to 2018
Authors: Malinis Maricar , La Hoz Ricardo M. , Vece Gabriel , Annambhotla Pallavi , Aslam Saima , Basavaraju Sridhar V. , Bucio Jamie , Danziger‐Isakov Lara , Florescu Diana F. , Jones Jefferson M. , Rana Meenakshi , Wolfe Cameron R. , Michaels Marian G. 
Published: January 2022

AbstractMycobacterium tuberculosiscan be transmitted via organ donation and result in severe outcomes. To better understand donor‐derived tuberculosis (DDTB), all potential transmissions reported to the Organ Procurement and Transplantation Network (OPTN) Ad Hoc Disease Transmission Advisory Committee between 2008 and 2018 were analyzed. Among 51 total reports, nine (17%) (9 donors/35 recipients) had ≥ 1 recipient with proven/probable disease transmission. Of these, eight were reported due to recipient disease, and one was reported due to a positive donor result. Proven/probable DDTB transmissions were reported in six lung and five nonlung recipients. The median time to diagnosis was 104 days posttransplant (range 0–165 days). Pulmonary TB, extrapulmonary TB, pulmonary plus extrapulmonary TB, and asymptomatic TB infection with positive interferon‐gamma release assay were present in five, three, one, and two recipients, respectively. All recipients received treatment and survived except for one whose death was not attributed to TB. All donors associated with proven/probable DDTB had ≥ 1 TB risk factor. Six were born in a TB‐endemic country, five had traveled to a TB‐endemic country, three had been incarcerated, and three had latent TB infection. These cases highlight the importance of evaluating donors for TB based on risk factors. Early posttransplant TB in organ recipients of donors with TB risk factors requires prompt reporting to OPTN to identify other potential affected recipients and implement timely treatment interventions.
The Gatekeepers to Fitness: A Correspondence Study to Examine Disabling Practices Among Fitness Center Personnel
Authors: Healy Sean 
Published: January 2022

Fitness centers may be an ideal setting for physical activity, yet qualitative findings suggest social-level barriers constrain access for people with disabilities. To further test this, I employed an online message correspondence study to investigate the effect of impairment status on the responsiveness of a national sample of fitness centers to requests for services. Email requests were sent to 800 fitness centers, of which 200 were tailored to each of the four investigative conditions (i.e., control, vision loss, spinal cord injury, or being autistic). The odds of receiving a positive response were 40.5% lower for individuals with vision loss (p = .011) and 33.3% lower for individuals with spinal cord injury (p = .055), as compared with individuals without an impairment. Specifically, the odds of receiving a positive response for personal training were 58.8% lower among individuals with vision loss (p = .003) and 41.1% lower for individuals with spinal cord injury (p = .065).
Metabolic and hormonal responses to chronic blood-flow restricted resistance training in chronic kidney disease: a randomized trial
Authors: Deus Lysleine Alves de , Corrêa Hugo de Luca , Neves Rodrigo Vanerson Passos , Reis Andrea Lucena , Honorato Fernando Sousa , Araújo Thaís Branquinho de , Souza Michel Kendy , Haro Anderson Sola , Silva Victor Lopes , Barbosa Jessica Mycaelle da Silva , Padula Isabela Akaishi , Andrade Rosângela Vieira , Simões Herbert Gustavo , Prestes Jonato , Stone Whitley J. , Melo Gislane Ferreira , Rosa Thiago Santos 
Published: January 2022

Maintenance of glycemic and lipemic homeostasis can limit the progression of diabetic kidney disease. Resistance training (RT) is effective in controlling glycemia and lipemia in kidney disease; however, the effect of RT with blood flow restriction (RT+BFR) on these metabolic factors has not been investigated. We aimed to verify if chronic (6 months) RT and RT+BFR performed by patients with stage-2 chronic kidney disease (CKD) improves their glycemic homeostasis and immunometabolic profiles. Patients with CKD under conservative treatment (n = 105 (33 females)) from both sexes were randomized into control (n = 35 (11 females); age 57.6 ± 5.2 years), RT (n = 35 (12 females); age 58.0 ± 6.2 years), and RT+BFR (n = 35 (10 females); 58.0 ± 6.4 years) groups. Chronic RT or RT+BFR (6 months) was performed 3 times per week on non-consecutive days with training loading adjusted every 2 months, RT 50%–60%–70% of 1RM, and RT+BFR 30%–40%+50% of 1RM and fixed repetition number. Renal function was estimated with the glomerular filtration rate and serum albumin level. Metabolic, hormonal, and inflammatory assessments were analyzed from blood samples. Six months of RT and RT+BFR were similarly effective in improving glucose homeostasis and hormone mediators of glucose uptake (e.g., irisin, adiponectin, and sirtuin-1), decreasing pro-inflammatory and fibrotic proteins, and attenuating the progression of estimated glomerular filtration rate. Thus, RT+BFR can be considered an additional exercise modality to be included in the treatment of patients with stage 2 chronic kidney disease. Trial registration number: U1111-1237-8231. URL: http://www.ensaiosclinicos.gov.br/rg/RBR-3gpg5w/ , no. RBR-3gpg5w.Novelty: Glycemic regulation induced by resistance training prevents the progression of CKD. Chronic RT and RT+BFR promote similar changes in glycemic regulation. RT and RT+BFR can be considered as non-pharmacological tools for the treatment of CKD.
Hyperon–anti-hyperon polarization asymmetry in relativistic heavy-ion collisions as an interplay between chiral and helical vortical effects
Authors: Ambru Victor E. , Chernodub M. N. 
Published: January 2022

AbstractWe argue that the enhancement in the spin polarization of anti-hyperons compared to the polarization of the hyperons in noncentral relativistic heavy-ion collisions arises as a result of an interplay between the chiral and helical vortical effects. The chiral vortical effect generates the axial current of quarks along the vorticity axis while the recently found helical vortical effect generates the helicity flow – the projection of the quark’s polarization vector onto its momentum – along the same axis. For massless fermions, the helical charge corresponds to a difference in the contributions of particles and anti-particles to the axial charge. Assuming that the spin of light quarks transfers to the strange quarks via the vector kaon states (“the spin-vector dominance”), we are able to describe the ratio of the (anti)hyperon spin polarizations, obtained by the STAR group, without fitting parameters. We also argue that the helical vortical effect dominates over the chiral vortical effect and the chiral magnetic effect in the generation of the electric current.
Quantification of “Cold-Hot” Medicinal Properties of Chinese Medicines Based on Primary Metabolites and Fisher’s Analysis
Authors: Wang Xian-rui , Cao Ting-ting , Tian Xue-mei , Wang Hui , Wang Yun 
Published: January 2022

Background. Chinese medicinal properties (CMP) are an important part of the basic theory of traditional Chinese medicines (TCMs). Quantitative research on the properties of TCMs is of great significance to deepen the understanding and application of the theory of drug properties and promoting the modernization of TCMs. However, these studies are limited to strong subjectivity or distinguish different drug properties based on certain indicators since CMP studies are diverse. Objective. To realize quantitative comparison of same medicinal properties of different Chinese medicines. Method. To solve the above problem, we proposed and explored quantification of Chinese medicinal properties (QMP) and the quantification value of medicinal properties “

R

”. The correlation between primary metabolites and “cold-hot” medicinal properties was explored on the premise of material basis of Chinese herbal medicines and Fisher’s analysis. Based on indicators related to “cold-hot” medicinal properties, we utilized quantitative values “

R

” to characterize the strength or weakness of “cold-hot” medicinal properties. Results. According to QMP, the same medicinal properties were quantified and compared by quantification value of medicinal properties that expressed by alphabet “

R

”. The general theoretical formula of “

R

” deduced is

R
=

l

×
cos

θ

/

L

=

∑

i
=
1

n

j

i

p

i

/

∑

i
=
1

n

p

i

2

, in which

n
≥
1

. In the light of formula of “

R

” and indicators related to “cold-hot” medicinal properties, we got “

R

” value of “cold-cool” and “warm-hot” medicinal properties. “

R

” values of “cold-cool” medicinal properties of Phellodendri chinensis cortex, Coptidis rhizoma, and Menthae haplocalycis herba were 0.63, 1.00, and 0.49, respectively. The result showed that Coptidis rhizoma is the most “cold-cool”, followed by Phellodendri chinensis cortex, with Menthae haplocalycis herba is the weakest in the three Chinese medicines, consistent with cognition of TCM theory. Conclusion. QMP has certain guiding significance for the quantification of “cold and hot” drug properties. “

R

” is feasible to realize the quantitative comparison of the same drug properties of different traditional Chinese medicine, which is helpful to promote process of modern Chinese medicine construction.
Quantitative Proxies for Social Norms: A Proposed Approach for Interrogating Clustering, Reference Groups, and Validity
Authors: Seff Ilana , Cislaghi Beniamino , Levtov Ruti , Vlahovicova Kristina , Stark Lindsay 
Published: January 2022

A growing number of researchers studying intimate partner violence (IPV) employ aggregate measures of relevant attitudes to serve as proxy measures for norms around IPV. However, there is a lack of consistency in how these measures are constructed and how their validity is confirmed. The first aim of this study is to demonstrate and validate innovative techniques for exploring social norms proxies in quantitative data and identifying the relative appropriateness of different available reference groups. The second aim is to demonstrate how such an approach can contribute to IPV research. The analysis employed data from the 2016 Tanzania International Men and Gender Equality Survey, including 1008 men and 1008 women ages 15–49 years. An attitudinal score measuring acceptance of IPV and two measures for individual-level descriptive and injunctive norms were constructed. The intraclass correlation coefficient (ICC) was used to assess the extent of clustering for the attitudinal score within several sets of groupings. Bivariate multi-level Ordinary Least Squares regressions estimated the predictive effect of an individual’s group norm proxy on their descriptive or injunctive norms. Attitudinal clustering was most significant for reference groups defined as males only across villages and males only across a combination of villages and marital status, with ICCs of 0.229 and 0.236, respectively. Men’s social norms were found to be correlated with reference groups comprised of both men only and women only, though men’s norms were substantially more correlated with the attitudes of men in their reference group than with women’s. Results highlight the importance of critically examining the validity of proxy measures for social norms prior to their inclusion in analysis. Findings also underscore the importance of collecting attitudinal data from men to better understand norms around IPV.
Performance and Integration of Smartphone Wireless ECG Monitoring into the Enterprise Electronic Health Record: First Clinical Experience
Authors: Cho Geoffrey W , Almeida Shone O , Gang Eli S , Elad Yaron , Duncan Ray , Budoff Matthew J , Karlsberg Ronald P 
Published: January 2022

Introduction: Patient initiated, remote cardiac monitoring has proved to be a significant advance in the diagnosis and management of arrhythmias. Further improvements in ease of use and access to results will further improve health outcomes and cost-effectiveness. Here we describe a proof-of-concept evaluation to assess the feasibility of successfully implementing a cloud-based management system using KardiaPro (KP) for remote electrocardiogram (ECG) monitoring to interface into EPIC, an enterprise electronic health record (EHR) system. Methods: The KP management system was embedded using hypertext markup language (HTML) code directly into the EHR. Encrypted credentials and patient data were bundled with an application programming interface key allowing linkage of remote monitoring from patients’ smartphones. During the time of implementation, a total of 322 patients and 32 179 ECGs were recorded. Results: The KP-EHR interface provided full functionality, allowing detection, interpretation and documentation of atrial fibrillation (AF), flutter events, ventricular tachycardia, and complete heart block. Our study focused on KP’s detection of AF, and 16.7% of tracings were classified as probable AF with only 2.3% of tracings not analyzed by the KP algorithm because of tracings that were too noisy or truncated. Enhanced management was facilitated with clinical information immediately accessible. Blinded physician ECG review validated the KP proprietary algorithm interpretation and ECGs. Conclusions: Direct integration of KP into EHR was successful and practical. It allows for historical, point of care and immediate retrieval of remote ambulatory monitoring data and documentation into the electronic health record. KP EHR integration warrants further study as it has the potential to improve cost-effectiveness and clinical diagnostic value, leading to improvements in delivery of patient care.
Barriers to early detection and management of oral cancer in the Asia Pacific region
Authors: Ng Sin Wi , Syamim Syed Mohd Sobri Sharifah Nur , Zain Rosnah binti , Kallarakkal Thomas George , Amtha Rahmi , Wiranata Wong Felix A , Rimal Jyotsna , Durward Callum , Chea Chanbora , Jayasinghe Ruwan Duminda , Vatanasapt Patravoot , Saleha binti Ibrahim Tamin Nor , Cheng Lai Choo , Mazlipah binti Ismail Siti , Tepirou Chher , Ariff bin Abdul Rahman Zainal , Rajendran Senthilmani , Kanapathy Jananezwary , Liew Chee Sun , Cheong Sok Ching 
Published: January 2022

Objective Oral cancer is amenable to early detection but remains a prominent cause of mortality in the Asia Pacific region. This study aimed to identify barriers to early detection and management of oral cancer in the Asia Pacific region. Methods A mixed-methods approach was employed triangulating findings from a survey and focus groups. The survey was conducted among seven representative members of the Asia Pacific Oral Cancer Network (APOCNET) across six countries. Focus groups were conducted to gain deeper insights into the findings of the survey. Results The identified barriers were a lack of national cancer control strategies and cancer registries and the limited availability of trained health care professionals. Overcoming these challenges in the Asia Pacific region where resources are scarce will require collaborative partnerships in data collection and novel approaches for continuous professional training including eLearning. Further, to overcome the lack of trained health care professionals, innovative approaches to the management of oral potentially malignant lesions and oral cancer including telemedicine were suggested. Conclusion The findings of this study should be taken into account when charting national cancer control plans for oral cancer and will form the basis for future collaborative studies in evaluating effective measures to improve oral cancer detection and management in low- and middle-income countries.