bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenging management of severe differentiation syndrome in pediatric acute promyelocytic leukemia treated with ATRA/ATO
Authors: Molinaro Alessandro , Zanta Daniela , Moleti Maria Luisa , Giona Fiorina , Conter Valentino , Rizzari Carmelo , Biondi Andrea , Testi Anna Maria 
Published: February 2022

The ATRA/ATO combination treatment of acute promyelocytic leukemia (APL) represents a paradigm of successful targeted and chemotherapy-free treatment in oncology. This therapeutic strategy is aimed at sparing patients from chemotherapy toxicity, while maintaining an excellent survival with a low risk of relapse. Main induction treatment-related complications are differentiation syndrome (DS) and hyperleukocytosis, which is related to DS and its severity. In the period December 2019 – December 2020, 8 children with newly diagnosed APL underwent induction therapy with ATRA/ATO in our center. In patients with WBC≥10x109/L two doses of Gemtuzumab Ozogamicin (GO) were added. In case of severe DS or hyperleukocytosis the differentiating agents were discontinued, high dose dexamethasone (DXM) and/or hydroxyurea (HU) were recommended. Five patients presented WBC<10x109/L ; all developed hyperleukocytosis and three also had DS and were initially treated with HU and DXM; due to unsatisfactory control of the symptoms GO was added in two of them.. One of the three patients with presenting WBC≥10x109/L, developed pseudotumor cerebri and another one DS. The supportive treatment was effective in all cases. Our experience shows that patients, treated with ATRA/ATO only, may develop marked hyperleukocytosis and severe DS, which may be unresponsive to discontinuation of differentiating agents and administration of HU and DXM and may benefit from the use of GO. Adequate intensive support therapy is crucial to rescue patients with severe DS.
Electrocoagulation Process Using Aluminum Electrodes for Treatment of Baker's Yeast Industry Wastewater
Authors: Arbabi Mohsen , Shafiei Samaneh , Mehraban Sadeghi , Khodabakhshi Abbas , Abdoli Ashkan , Arbabi Arman 
Published: February 2022

Background and Aims:
Severe contamination with organic compounds and very high color is characteristic of yeast industry wastewater. Discharging this wastewater into the environment has adverse effects on the environment. The present study was conducted to determine the efficiency of the electrocoagulation (EC) using aluminum electrodes for the removal of color, turbidity, and chemical oxygen demand (COD) from the baker's yeast industry wastewater.

Materials and Methods:
In this experimental study, the effect of current densities (60, 80, 100, and 120 A/m2) and reaction times (15, 30, 45, and 60 min) using aluminum electrode was investigated on removal efficiencies of COD, color, and turbidity. The pilot consisted of a reactor with a useful volume of 2.5 l of epoxy glass, a direct current power supply, and aluminum electrodes of 8 cm × 8 cm in diameter.

Results:
The highest removal efficiencies were obtained to be 83% for COD, 93% for color, and 96% for turbidity at density of 80 A/m2 and 45-min contact time (pH = 7). Under these conditions, the power and electrode consumption was 16.89 kWh and 94.3 g/m3, respectively, and the treatment cost of wastewater was estimated to be 1.5 $ per each cubic meter.

Conclusion:
The results showed that EC process using aluminum electrode is an appropriate and effective method for removing color, turbidity, and COD from baking industry wastewater.
The Effect of White Noise Exposure on Anxiety and Hemodynamic Parameters of Operating Room Staff
Authors: Shahrokhi Shabnam , Mirhosseini Hamid , Halvani Gholam Hossein , Jambarsang Sara 
Published: February 2022

Aim:
Anxiety reduces performance at work. Anxiety is significantly prevalent among medical staff in general, and especially operating room staff. The present study was an attempt to investigate the effect of suction-induced white noise on anxiety and hemodynamic parameters of operating room staff during cesarean section.

Materials and Methods:
The present study was a crossover, single-blind clinical trial on 29 scrub staff during cesarean section. The subjects were assigned once to the control group and once to the intervention group with a 10-day washout period. In the intervention group, the suction machine was left on during surgery for 3 days in a row, but in the control group, the suction machine was switched off in idle times to make sure that noise exposure time would remain below 30 min. Hemodynamic parameters of subjects were measured on the last day immediately after surgery, and the Spielberger State-Trait Anxiety Inventory was used to measure the level of anxiety. SPSS 22 software and linear mixed model were used to analyze the collected data.

Results:
The control and intervention groups were not significantly different in terms of hemodynamic parameters, anxiety as well as the carryover-crossover effects (P > 0.05). A significant negative correlation was observed between anxiety score and age of the subjects (P < 0.05).

Conclusions:
Suction-induced white noise has no effect on anxiety and hemodynamic parameters of operating room staff. Adaptation to workplace noises can reduce the adverse effects of noise.
Investigating Flubendazole as an Anthelmintic Treatment for Guinea Worm (Dracunculus medinensis): Clinical Trials in Laboratory-Reared Ferrets and Domestic Dogs in Chad
Authors: Cleveland Christopher A. , Garrett Kayla B. , Box Erin K. , Thompson Alec T. , Haynes Ellen K. , Elder Deborah L. , Richards Robert L. , Majewska Ania A. , Guagliardo Sarah Anne J. , Wiegand Ryan E. , Bryan II John A. , Torres-Velez Fernando , Unterwegner Karmen , Romero Mario , Zirimwabagabo Hubert , Sidouin Metinou , Oaukou Philip Tchindebet , Ada Mbang Mahammat , Ngandolo Bongo Nare Richard , Mackenzie Charles D. , Geary Timothy G. , Weiss Adam J. , Yabsley Michael J. 
Published: February 2022

ABSTRACT.
Dracunculus medinensis (Guinea worm [GW]), a zoonotic nematode targeted for eradication, has been managed using interventions aimed at humans; however, increases in domestic dog GW infections highlight the need for novel approaches. We conducted two clinical trials evaluating the efficacy of subcutaneously injected flubendazole (FBZ) as a treatment of GW infection. The first trial was conducted administering FBZ to experimentally infected ferrets; the second trial involved administering FBZ or a placebo to domestic dogs in the Republic of Tchad (Chad). We found contrasting results between the two trials. When adult gravid female GW were recovered from ferrets treated with FBZ, larvae presented in poor condition, with low to no motility, and an inability to infect copepods. Histopathology results indicated a disruption to morulae development within uteri of worms from treated animals. Results from the trial in Chadian dogs failed to indicate significant treatment of or prevention against GW infection. However, the difference in treatment intervals (1 month for ferrets and 6 months for dogs) or the timing of treatment (ferrets were treated later in the GW life-cycle than dogs) could explain different responses to the subcutaneous FBZ injections. Both trials provided valuable data guiding the use of FBZ in future trials (such as decreasing treatment intervals or increasing the dose of FBZ in dogs to increase exposure), and highlighted important lessons learned during the implementation of a field-based, double-blinded randomized control trial in Chadian dogs.
Phenotypic characterization of local goat population in western Algeria (Wilaya of Relizane) with morphometric measurements and milk analysis
Authors: BELANTAR Ibrahim , TEFIEL Hakim , Gaouar Semir Bechir Suheil 
Published: February 2022

A morphological characterization of the local goat population with physicochemical analysis of milk was performed in the wilaya of Relizane. This study was conducted on 50 goats (42 does and 8 bucks) in 6 districts of Relizane. The goat farming in Relizane is mixed with sheep farming but sheep are the main purpose of the breeding for pure economical purposes (wool and meat), goats are used mainly to guide the herd during the grazing, the goats do not receive an important livestock management, their reproduction is uncontrolled and the milk is only used for family consumption. Nine qualitative and twelve quantitative variables were used to study our samples. 68 % of our samples have horns with the curved horns as the most dominant shape, the pendant ears are found at 62%, concerning the beard 52% of does and 12% of bucks have beard, whereas only 8% of does and 2% of bucks have wattles. A negative correlation of was found between ear length (LOr) and lactose level (LACT), a negative correlation of was found between ear length (LOr) and protein level (PROT). Principal Component Analysis (PCA) revealed that Body length (LC), Height at withers (HG), Chest circumference (TP), Chest depth (PP), Horn length (LCo) and Ear length (LOr) characterizes better our goats. The hierarchical cluster analysis (HCA) by the PCA showed three distinct groups in our samples. The classification of our samples according to the ear length, from the results of the PCA, showed that ears length is a discriminative factor in our sampling. The descriptive analysis of the milk revealed that the milk is of good quality with a fat content of 47.82 g / kg, a protein content of 33.35 g / kg and lactose of 48.82 g / kg.
Genetic Variations in Thomas’s Rope Squirrel (Funisciurus anerythrus) and Gambian Sun Squirrel (Heliosciurus gambianus) Ibadan, Nigeria, Using Allozyme Markers
Authors: Oluwakayode M Coker , Osamede H Osaiyuwu , Otobong M Isong 
Published: February 2022

Thomas’s Rope Squirrel (Funisciurus anerythrus) and Gambian Sun Squirrel (Heliosciurus gambianus) are two of the eight squirrel species found in Nigeria with overlapping habitats in Southwestern Nigeria. Squirrels are involved in pollination, seed dispersal, vectors of human and domestic animal diseases as well as crop and household pests. These species and the crucial ecosystem services they render are threatened by habitat destruction, human encroachment and the fact that they are being used as a source of protein in Nigeria. Their conservation would be enhanced by availability of accurate genetic information which are scarce for these species. This study seeks to provide baseline data on genetic variation at three allozyme loci in the two species in University of Ibadan, Ibadan, Nigeria. Twenty-nine individual squirrels including eighteen F. anerythrus species and eleven H. gambianus were used in this study. These were obtained from the wild within the University of Ibadan. Observed and expected heterozygosity (Ho and He), Hardy-Weinberg equilibrium (HWE), genetic distance between the species, and inbreeding coefficients were performed using POPGENE and Tools for Population Genetic Analyses (TFPGA). In F. anerythrus, Ho and He were 0.6092 and 0.5635, respectively, while, for H. gambianus, Ho and He were 0.6242 and 0.5745, respectively. There were no deviations from HWE in all the tested loci (p>0.05). Nei genetic distance between the species was 0.0070 and the populations showed fairly high level of outbreeding (FST = 0.0029 ± 0.0017). More robust genetic markers would be required to further ascertain the genetic status of the species.
The Problems Affecting the Implementation of Posyandu Program: A Literature Review
Authors: Suparto Tirta Adikusuma , Nur Azizah Nadia , Andriyani Septian , Wahyoe Puspita Asih Purwandari , Hermayanti Yanti 
Published: February 2022

Integrated Health Post for Child Center/Pos Pelayanan Terpadu (Posyandu) is a form of community-based health program carried out by, from, and along with the community to empower and provide facilities for the community to obtain health services for mothers, babies, and toddlers. Posyandu activities include: KIA, family planning, immunization, nutrition, diarrhea prevention. Posyandu in Indonesia still faced several problems. This study aimed at investigating the problems that affect the implementation of Posyandu program and actions to improve Posyandu program services. The method used in this study was literature review. The literatures used in this study were the search results through national and international journals. National includes google scholar [https://scholar.google.co.id/] and international includes Pubmed [https://www.ncbi.nlm.nih.gov/pubmed] with the keyword “Problems and Posyandu Program” published in 2016-2020. Based on the search results, 8 national and 2 international articles related to the topic and in accordance with the inclusion and exclusion criteria were found. The results of 10 literature reviews show there are several fundamental problems of Posyandu program in Indonesia, namely: 1) the low role of Posyandu cadres; 2) the lack of understanding on the benefit of Posyandu program; 3) The lack of participation in Posyandu activities; 4) The lack of facilities and infrastructure for Posyandu activities; and 5) the lack of cross-program and cross-sector cooperation. In addition, there are 5 actions needed to solve the problems. The first action is to conduct a training program for Posyandu cadres. The second one is to conduct regular outreach at Posyandu for mothers and families by trained cadres. The third one is to improve the facilities and infrastructure in Posyandu. The fourth one is to provide both material and immaterial incentives for an active Posyandu’s cadre. Lastly, the fifth action is to increase advocacy efforts to related parties. Posyandu program are still facing problems affecting its implementation. Therefore, the posyandu revitalization actions are needed. The main key lies in increasing cadres' capacity through training.
TINJAUAN ANALISIS PERHITUNGAN KEBUTUHAN AIR BERSIH DAN AIR LIMBAH UNTUK PERENCANAAN SISTEM PENYALURAN AIR LIMBAH DI PERUMAHAN BUMI CIRUAS PERMAI 1 KABUPATEN SERANG
Authors: Pangesti Frebhika Sri Puji , Ariesmayana Ade 
Published: February 2022

Perumahan Bumi Ciruas Permai I terletak di Kecamatan Ciruas Kabupaten Serang. Kawasan ini mempunyai luas sebesar 253.839 m2 dan jumlah populasi penduduknya sebesar 1352 jiwa. Jumlah penduduk dari tahun ke tahun semakin meningkat, dengan peningkatan jumlah penduduk tersebut berakibat kebutuhan air bersih dan air limbah yang ada di Perumahan Bumi Ciruas Permai I juga mengalami peningkatan. Wilayah perumahan Bumi Ciruas Permai I berdasarkan area beresiko sanitasi termasuk kedalam kategori sanitasi sangat tinggi. Greywater yang dihasilkan langsung dibuang ke saluran drainase tanpa pengolahan, sedangkan sisa air buangan (black water) yang mengandung urine dan tinja akan ditampung ke dalam tangki septic. Upaya meminimalisir pencemaran diperlukan perencanaan sistem penyaluran air limbah dengan sistem terpusat, sehingga diperlukan peninjauan tingkat kebutuhan air bersih dan air limbah pada wilayah tersebut. Berdasarkan hasil perhitungan didapatkan total kebutuhan air bersih domestik dan kebutuhan air non domestik (fasilitas umum) pada Perumahan Bumi Ciruas Permai I tahun 2029 sebesar 316.546 liter/hari.Debit air limbah masyarakat Perumahan Bumi Ciruas Permai I sebesar 253,237 m3/hari, sedangkan debit air limbah grey water sebesar 189,92 m3/hari. Hasil perhitungan tersebut akan dijadikan dasar dalam perencanaan sistem penyaluran air limbah sesuai dengan Peraturan Menteri Pekerjaan Umum dan Perumahan Rakyat No. 4 Tahun 2017 Tentang Penyelenggaran Sistem Pengelolaan Air Limbah Domestik (SPALD).
Esperanza, autonomía e innovación social: punto de partida para el análisis de experiencias de producción social de vivienda y hábitat
Authors: Manzano Morán Carlos A. 
Published: February 2022

El objetivo del artículo es presentar una exploración teórica que sirva como punto de partida para la construcción de un modelo para el análisis comparativo de experiencias alternativas de producción de vivienda y hábitat en la región Latinoamericana. Inicia con una contextualización general donde se puntualizan algunas de las principales problemáticas del sector vivienda al interior de los procesos urbanos contemporáneos, enfatizando en la emergencia de experiencias alternativas de autoproducción organizada y en la necesidad de la puesta en diálogo de la tradición empírica acumulada con teorías urbanas y otras corrientes de pensamiento. Posteriormente se pasa a articular los conceptos de Producción Social de Vivienda y Hábitat (PSVH), Innovación Social (IS), Esperanza y Autonomía, mediante la exploración de aportes teóricos provenientes de distintos campos (sociología, geografía, filosofía, estudios urbanos, etc.) concluyendo en las siguientes ideas: 1/ El concepto de PSVH, al contraponerse a la visión neoliberal de la vivienda como bien de mercado, es muy útil para categorizar experiencias de autoproducción de vivienda organizada, que respondan a principios contrahegemónicos y que se basen en una visión de derechos humanos; 2/ Es posible referirnos a Innovación Social de Hábitat (IS-H), es decir enmarcar las experiencias de PSVH en procesos sociales más amplios de Innovación Social, en tanto estas se dinamicen a partir de prácticas organizadas arraigadas en el territorio, estén comprometidas a procesos de desarrollo territorial, y cuando el suelo (su acceso y gestión) se identifique como producto y objetivo del proceso reivindicativo y creativo de IS-H; 3/ La Esperanza actúa como la fuerza dinamizadora y orientadora de los procesos de IS-H cuando se origina a partir de procesos reiterativos de coproducción de conocimiento (desde la base social) capaces de desencadenar procesos de prefiguración espacio-temporales afianzados en los recursos territoriales del presente y materializados en prácticas cotidianas orientadas a la anticipación de un futuro que ‘aún no es’; y 4/ Experiencias de IS-H se embarcan en un proyecto de Autonomía, cuando estas forma parte de un proyecto político de organización de la esperanza comprometido a la materialización de un proyecto de vida alternativo y contrahegemónico, basado en la autodeterminación y en la voluntad de romper con condiciones estructurales de opresión y desigualdad.
ECA Estudios Centroamericanos, Vol. 76, No. 767, 2021: 479-500.
Mártires de la UCA: amigos de Dios y profetas. “Memoria, discernimiento y profecía”. Homilía del cardenal Gregorio Rosa Chávez, 16 de noviembre de 2021, en el XXXII aniversario de los Mártires de la UCA
Authors: Rosa Chávez Gregorio 
Published: February 2022

La homilía predicada en la celebración Eucarística en ocasión del XXXII aniversario de los Mártires de la UCA inicia rememorando los mártires del Paraguay, Roque González y compañeros mártires, cuya fiesta conmemorativa se celebra el mismo día que los mártires de la UCA. Se destacan algunos hechos significativos de la vida de Roque Gonzales como ilustrativo de lo que significa la defensa de los pobres. La inatención a la memoria se critica porque lleva a la indiferencia y a la persecución. Hoy en día la persecución se hace por medio de la mentira, la calumnia y la acusación infundada. La relación entre memoria, discernimiento y profecía se resaltan como centrales en la vida de los mártires de la UCA. Se exhorta a soñar proféticamente como muestra de estar atentos a la palabra de Dios y a una vida cristiana comprometida.
ECA Estudios Centroamericanos, Vol. 76, No. 767, 2021: 545-552.
Challenges of Teaching Chinese as a Subject in an English-dominated Region: Focus on Sindh, Pakistan
Authors: Ameer Ali  , David Maya Khemlani 
Published: February 2022

Sindh is a multilingual province in Pakistan where politics of language and clash of language ideologies have played a significant role. English is viewed as a language of power, and Urdu is generally considered as a symbol of national cohesion in Pakistan. In Sindh both these languages are used in official and educational domains In Sindh’s language ecology, English occupies an important position. In addition to these two languages, Sindhi is widely spoken and is associated with Sindh’s regional and ethnic consciousness. Pakistan's pivot to China policy is slowly impacting language policy and planning in Sindh. Politicians have started talking about making Chinese a compulsory subject from grade 6 onwards in Sindh’s educational institutions. However, this language policy decision has met resistance from the English-speaking class, and the Urdu, Seraiki, and Sindhi speech communities who look at the imposition of Chinese language with distrust. The aim of this research article is to investigate how language teachers and students in Sindh react to the Chinese language policy and planning. A survey questionnaire was sent to participants to explore their perceptions of imposing the Chinese language in Sindh. 33 participants aged between 20 to 40 responded to 14 questions included in the survey. Extracts taken from their responses were codified into broader themes and qualitative analysis was carried out using Philipson’s (1992) imperialism concept. The findings showed that the pro-Chinese class is struggling to replace English in an ecology of language where speakers of minor languages are already resisting the hegemony of major languages. Key words: Chinese; English; Languages; Sindhi; Urdu
Speech acts of complaining on the review page of the e-commerce platforms in Indonesia
Authors: Fiqih Emier Abdul , Sudana Dadang 
Published: February 2022

The study aims to investigate the speech act of complaint that is realized by costumers on review page of the e-commerce platforms in Indonesia. This study uses speech acts of complaint categorized by Trosborg and aspects of perlocutionary acts by Leech. The object studied are negative reviews found on the review pages of the e-commerce platforms which is analyzed by using a descriptive qualitative research. The results showed that Annoyances is the most realized and Explicit blame (person) is the least realized speech act of complaint from customers. Also, the respond from seller tends to bring hearer to know as the most realized perlocutionary acts.