bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pro-inflammatory cytokines mediate the epithelial-to-mesenchymal-like transition of pediatric posterior fossa ependymoma
Authors: Aubin Rachael G. , Troisi Emma C. , Montelongo Javier , Alghalith Adam N. , Nasrallah Maclean P. , Santi Mariarita , Camara Pablo G. 
Published: July 2022

AbstractPediatric ependymoma is a devastating brain cancer marked by its relapsing pattern and lack of effective chemotherapies. This shortage of treatments is due to limited knowledge about ependymoma tumorigenic mechanisms. By means of single-nucleus chromatin accessibility and gene expression profiling of posterior fossa primary tumors and distal metastases, we reveal key transcription factors and enhancers associated with the differentiation of ependymoma tumor cells into tumor-derived cell lineages and their transition into a mesenchymal-like state. We identify NFκB, AP-1, and MYC as mediators of this transition, and show that the gene expression profiles of tumor cells and infiltrating microglia are consistent with abundant pro-inflammatory signaling between these populations. In line with these results, both TGF-β1 and TNF-α induce the expression of mesenchymal genes on a patient-derived cell model, and TGF-β1 leads to an invasive phenotype. Altogether, these data suggest that tumor gliosis induced by inflammatory cytokines and oxidative stress underlies the mesenchymal phenotype of posterior fossa ependymoma.
A calibratable sensory neuron based on epitaxial VO2 for spike-based neuromorphic multisensory system
Authors: Yuan Rui , Duan Qingxi , Tiw Pek Jun , Li Ge , Xiao Zhuojian , Jing Zhaokun , Yang Ke , Liu Chang , Ge Chen , Huang Ru , Yang Yuchao 
Published: July 2022

AbstractNeuromorphic perception systems inspired by biology have tremendous potential in efficiently processing multi-sensory signals from the physical world, but a highly efficient hardware element capable of sensing and encoding multiple physical signals is still lacking. Here, we report a spike-based neuromorphic perception system consisting of calibratable artificial sensory neurons based on epitaxial VO2, where the high crystalline quality of VO2 leads to significantly improved cycle-to-cycle uniformity. A calibration resistor is introduced to optimize device-to-device consistency, and to adapt the VO2 neuron to different sensors with varied resistance level, a scaling resistor is further incorporated, demonstrating cross-sensory neuromorphic perception component that can encode illuminance, temperature, pressure and curvature signals into spikes. These components are utilized to monitor the curvatures of fingers, thereby achieving hand gesture classification. This study addresses the fundamental cycle-to-cycle and device-to-device variation issues of sensory neurons, therefore promoting the construction of neuromorphic perception systems for e-skin and neurorobotics.
Analysis on curve negotiating ability of rail grinder in grinding state
Authors: Zeng Luqing , Cui Dabin , Fu Yaodong , Li Li , Liu Zhanghong 
Published: July 2022

AbstractRail grinding becomes an important maintenance means of railway. Dynamic behavior of rail grinder is due to vehicle-track coupling relationship based on mechanical-electric-hydraulic coupling. Curve negotiating ability of rail grinder through modeling and simulation based on one-side grinding is studied in this paper. Simulation result is shown below. In typical case, rail grinding will increase transverse displacement of wheelsets, derailment coefficient of wheels in front wheelset, and unloading rate of wheelsets. In other case, increase of rail irregularity amplitude and decrease of its wavelength, which aggravates fluctuation of grinding power, has little influence on curve negotiating ability. When line radius curvature decreases, compared to state without grinding, decline to curve negotiating ability of state with grinding is more significantly. When number of grinding wheels at work increases, lateral displacement of wheelset, derailment coefficient of wheels in front wheelset, and unloading ratio of wheelsets increase. In short, rail grinding will significantly deteriorate curve negotiating ability of rail grinder.
Clinical utility of simple subjective gait speed for the risk stratification of heart failure in a primary prevention setting
Authors: Ueno Kensuke , Kaneko Hidehiro , Kamiya Kentaro , Itoh Hidetaka , Okada Akira , Suzuki Yuta , Matsuoka Satoshi , Fujiu Katsuhito , Michihata Nobuaki , Jo Taisuke , Takeda Norifumi , Morita Hiroyuki , Ako Junya , Yasunaga Hideo , Komuro Issei 
Published: July 2022

AbstractLittle is known regarding the relationship between self-reported gait speed and the subsequent risk of heart failure (HF) and cardiovascular disease (CVD). We sought to clarify the clinical utility of self-reported gait speed in primary CVD prevention settings. This is an observational cohort study using the JMDC Claims Database, which is an administrative health claims database. Data were collected between January 2005 and April 2020. Medical records of 2,655,359 participants without a prior history of CVD were extracted from the JMDC Claims Database. Gait speed was assessed using information from questionnaires provided at health check-ups, and study participants were categorized into fast or slow gait speed groups. The primary outcome was HF. The secondary outcomes included myocardial infarction (MI), angina pectoris (AP), and stroke. The median age was 45.0 years, and 55.3% of participants were men. 46.1% reported a fast gait speed. The mean follow-up period was 1180 ± 906 days. HF, MI, AP, and stroke occurred in 1.9%, 0.2%, 1.9%, and 1.0% of participants, respectively. Multivariable Cox regression analyses showed that, compared with slow gait speed, fast gait speed was associated with a lower incidence of HF, MI, AP, and stroke. The discriminative predictive ability for HF significantly improved by adding self-reported gait speeds to traditional risk factors (net reclassification improvement 0.0347, p < 0.001). In conclusion, our analysis demonstrated that subjective gait speed could be a simple method to stratify the risk of HF and other CVD events in the general population. Further investigations are required to clarify the underlying mechanism of our results and to develop a novel approach for primary CVD prevention.
Preventive health behaviors among people with suicide ideation using nationwide cross-sectional data in South Korea
Authors: Ki Myung , Shim Hye-Young , Lim Jiseun , Hwang Minji , Kang Jiwon , Na Kyoung-Sae 
Published: July 2022

AbstractThis study aimed to investigate the association between suicide ideation and health-related behaviors and preventive health service use behaviors. We used data from the 2017 Korea National Health and Nutrition Examination Survey (KNHANES), a nationally representative survey. The final sample included 4486 participants aged 40 years or older. Preventive health behaviors were assessed for smoking, high-risk drinking, physical activities, regular meal intake, influenza vaccination, general health examination, and cancer screening. Logistic regression was used to examine the association between suicide ideation and preventive health behaviors with a series of adjustments for covariates. In general, suicide ideation was associated with unfavorable outcomes of preventive health behaviors, except for flu vaccination. For example, the crude prevalence of suicide ideation and non-suicide ideation groups were 54.3% vs. 43.7% for flu vaccination, 23.1% vs. 41.6% for physical activity, and 24.8% vs. 18.6% for high-risk alcohol drinking. After adjustment for covariates, the associations of suicide ideation with behaviors remained significant for physical activity (OR 0.52, 95% CI 0.34–0.81) and high-risk alcohol drinking (OR 2.22, 95% CI 1.34–3.69). Suicide ideation leads to the disruption of self-management of health behaviours, especially for physical activity and high-risk alcohol drinking, independently of depressive feelings.
Antenna movements as a function of odorants’ biological value in honeybees (Apis mellifera L.)
Authors: Cholé Hanna , Merlin Alice , Henderson Nicholas , Paupy Estelle , Mahé Prisca , Arnold Gérard , Sandoz Jean-Christophe 
Published: July 2022

AbstractIn honeybees, the antennae are highly mobile sensory organs that express scanning movements in various behavioral contexts and toward many stimuli, especially odorants. The rules underlying these movements are still unclear. Using a motion-capture system, we analyzed bees’ antennal responses to a panel of pheromonal and other biologically relevant odorants. We observed clear differences in bees’ antennal responses, with opposite movements to stimuli related to opposite contexts: slow backward movements were expressed in response to alarm pheromones, while fast forward movements were elicited by food related cues as well as brood and queen related pheromones. These responses are reproducible, as a similar pattern of odor-specific responses was observed in bees from different colonies, on different years. We then tested whether odorants’ attractiveness for bees, measured using an original olfactory orientation setup, may predict antenna movements. This simple measure of odorants’ valence did however not correlate with either antennal position or velocity measures, showing that more complex rules than simple hedonics underlie bees’ antennal responses to odorants. Lastly, we show that newly-emerged bees express only limited antennal responses compared to older bees, suggesting that a significant part of the observed responses are acquired during bees’ behavioral development.
The rise of electrochromics through dynamic QR codes and grayscale images in screen printed passive matrix addressed displays
Authors: Andersson Ersman Peter , Freitag Kathrin , Kawahara Jun , Åhlin Jessica 
Published: July 2022

AbstractElectronic matrix addressed displays capable of presenting arbitrary grayscale images typically require complex device architectures including switching components to provide unique pixel addressability. Here, we demonstrate high-yield manufacturing of passive matrix addressed electrochromic displays on flexible substrates by solely using screen printing. The simple pixel architecture, obtained by printing only three active layers on top of each other, concurrently provides both the electrochromic functionality and the critical non-linear pixel switching response that enables presentation of arbitrary grayscale images in the resulting passive matrix addressed displays. The all-printed display technology exhibits unprecedented performance and is further verified by dynamic QR codes, to exemplify utilization within authentication, packaging, or other emerging Internet of Things applications requiring a low-cost display for data visualization.
Quantum annealing with special drivers for circuit fault diagnostics
Authors: Leipold Hannes , Spedalieri Federico M. 
Published: July 2022

AbstractWe present a very general construction for quantum annealing protocols to solve Combinational Circuit Fault Diagnosis problems that restricts the evolution to the space of valid diagnoses. This is accomplished by using special local drivers that induce a transition graph on the space of feasible configurations that is regular and instance independent for each given circuit topology. Analysis of small instances shows that the energy gap has a generic form, and that the minimum gap occurs in the last third of the evolution. We used these features to construct an improved annealing schedule and benchmarked its performance through closed system simulations. We found that degeneracy can help the performance of quantum annealing, especially for instances with a higher number of faults in their minimum fault diagnosis. This contrasts with the performance of classical approaches based on brute force search that are used in industry for large scale circuits.
Using historical tropical cyclone climate datasets to examine wind speed recurrence for coastal Australia
Authors: Bell S. S. , Dowdy A. J. , Ramsay H. A. , Chand S. S. , Su C-H , Ye H. 
Published: July 2022

AbstractLikelihood estimates of extreme winds, including those from tropical cyclones (TCs) at certain locations are used to inform wind load standards for structural design. Here, wind speed average recurrence intervals (ARIs) determined from TC climate data dating back to the 1970s in two quantile–quantile adjusted reanalysis datasets (ERA5 and BARRA [1990]), and best-track observations for context, were compared with Standardized ARIs (AS/NZS) across seven tropical and two subtropical Australian inland coastal regions. The novelty of this work lies in determining TC-wind speed ARIs from a range of datasets that are not typically used to evaluate this metric. Inherent differences between the data used to determine the Standard ARIs (large sample size allow for larger extrapolations; GEV function) and TC data ARIs (smaller sample size and less certain data; the more asymptotic Lognormal/Weibull functions are used) led to the use of different extreme value functions. Results indicated that although these are two distinct ways of determining design wind speeds, when they are considered equivalent, there was a moderate reproduction of the ARI curves with respect to the Standard in both reanalysis datasets, suggesting that similar analyses using climate model products can provide useful information on these types of metrics with some caveats. Trends in TC wind strength affecting coastal Australia were also analyzed, indicating a potential slight downtrend in tropical West coast TC wind strength and slight uptrend for tropical East coast TC wind strength, noting considerable uncertainty given the short time period and limitations of data quality including over longer time periods. Such trends are not only limited to the relationship between TC intensity and anthropogenic warming, but also to regional changes in TC frequency and track direction. This could lead to significant trends emerging in regional Australian TC wind gust strength before several decades of warming have occurred. It is hoped that climate models can provide both longer-term and a more homogenous base for these types of evaluations and subsequent projections with respect to climate change simulations.
Electron beam surface remelting enhanced corrosion resistance of additively manufactured Ti-6Al-4V as a potential in-situ re-finishing technique
Authors: Shahsavari Mohammadali , Imani Amin , Setavoraphan Andaman , Schaller Rebecca Filardo , Asselin Edouard 
Published: July 2022

AbstractThis study explores the effect of surface re-finishing on the corrosion behavior of electron beam manufactured (EBM) Ti-G5 (Ti-6Al-4V), including the novel application of an electron beam surface remelting (EBSR) technique. Specifically, the relationship between material surface roughness and corrosion resistance was examined. Surface roughness was tested in the as-printed (AP), mechanically polished (MP), and EBSR states and compared to wrought (WR) counterparts. Electrochemical measurements were performed in chloride-containing media. It was observed that surface roughness, rather than differences in the underlying microstructure, played a more significant role in the general corrosion resistance in the environment explored here. While both MP and EBSR methods reduced surface roughness and enhanced corrosion resistance, mechanical polishing has many known limitations. The EBSR process explored herein demonstrated positive preliminary results. The surface roughness (Ra) of the EBM-AP material was considerably reduced by 82%. Additionally, the measured corrosion current density in 0.6 M NaCl for the EBSR sample is 0.05 µA cm−2, five times less than the value obtained for the EBM-AP specimen (0.26 µA cm−2).
Inhibitor induced conformational changes in SARS-COV-2 papain-like protease
Authors: Ferreira Glaucio Monteiro , Pillaiyar Thanigaimalai , Hirata Mario Hiroyuki , Poso Antti , Kronenberger Thales 
Published: July 2022

AbstractSARS-CoV-2’s papain-like protease (PLpro) interaction with ligands has recently been explored with a myriad of crystal structures. We used molecular dynamics (MD) simulations to study different PLpro-ligand complexes, their ligand-induced conformational changes, and interactions. We focused on inhibitors reported with known IC50 against PLpro, namely GRL-0617, XR8-89, PLP_Snyder530, and Sander’s recently published compound 7 (CPD7), and compared these trajectories against the apostructure (Apo), with a total of around 60 µs worth simulation data. We aimed to study the conformational changes using molecular dynamics simulations for the inhibitors in the PLpro. PCA analyses and the MSM models revealed distinct conformations of PLpro in the absence/presence of ligands and proposed that BL2-loop contributes to the accessibility of these inhibitors. Further, bulkier substituents closer to Tyr268 and Gln269 could improve inhibition of SARS-CoV-2 PLpro by occupying the region between BL2-groove and BL2-loop, but we also expand on the relevance of exploring multiple PLpro sub-pockets to improve inhibition.
Effects of cavity orientation on nesting success inferred from long-term monitoring of the endangered red-cockaded woodpecker
Authors: Landler Lukas , Skelton James , Jusino Michelle A. , Van Lanen Andy , Walters Jeffrey R. 
Published: July 2022

AbstractAnimals that create structures often display non-random patterns in the direction of their constructions. This tendency of oriented construction is widely presumed to be an adaptive trait of the constructor’s extended phenotype, but there is little empirical support for this hypothesis. Particularly, for cavity nesting-birds there is a lack of studies examining this issue. In this study of a primary cavity excavator, the endangered red-cockaded woodpecker (Dryobates borealis), we show that cavity entrances exhibited a strong westward bias in all 11 of the populations examined throughout the geographic range of the species in the southeastern United States. This species requires cavities in living pine trees for roosting and nesting that often take many years to complete, resulting in many incomplete excavations on the landscape. We used population monitoring data to show that orientation was stronger among completed cavities than incomplete cavities. There was a significant correlation between latitude and average cavity direction among populations, turning northward with increasing latitude, suggesting adaptation to local conditions. Long-term monitoring data showed that cavity orientation and breeding group size are correlated with egg hatching rates, fledging rates, and the total number of fledglings produced per nest. Our results provide empirical evidence from extensive long-term data that directional orientation in animal constructions is an important feature of the extended animal phenotype and have immediate implications for animal ecology and the conservation of endangered species.
Leveraging physical intelligence for the self-design of high performance engineering structures
Authors: Paixão Jessé , Sadoulet-Reboul Emeline , Foltête Emmanuel , Chevallier Gaël , Cogan Scott 
Published: July 2022

AbstractThe design of complex engineering structures largely relies on computational intelligence in the form of science-based predictive models to support design decisions. This approach requires modeling and manufacturing uncertainties to be accounted for explicitly and leads to an inescapable trade-off of performance for robustness. To remedy this situation, a novel self-design paradigm is proposed that closes the loop between the design and manufacturing processes by leveraging physical intelligence in the form of real-time experimental observations. This allows the real-time product behavior to participate in its own design. The main benefit of the proposed paradigm is that both manufacturing variability and difficult-to-model physics are accounted for implicitly via in situ measurements thus circumventing the performance-robustness trade-off and guaranteeing enhanced performance with respect to standardized designs. This paradigm shift leads to tailored design realizations which could benefit a wide range of high performance engineering applications. The proposed paradigm is applied to the design of a simply-supported plate with a beam-like absorber introduced to reduce vibrations based on an equal peaks performance criteria. The experimental setup includes a low-cost 3D printer driven by a simple decision algorithm and equipped with an online vibration testing system. The performances of a small population of self-designed plates are compared to their standardized counterparts in order to highlight the advantages and limitations of the new self-design manufacturing paradigm.
Integrated socio-environmental vulnerability assessment of coastal hazards using data-driven and multi-criteria analysis approaches
Authors: Tanim Ahad Hasan , Goharian Erfan , Moradkhani Hamid 
Published: July 2022

AbstractCoastal hazard vulnerability assessment has been centered around the multi-variate analysis of geo-physical and hydroclimate data. The representation of coupled socio-environmental factors has often been ignored in vulnerability assessment. This study develops an integrated socio-environmental Coastal Vulnerability Index (CVI), which simultaneously combines information from five vulnerability groups: biophysical, hydroclimate, socio-economic, ecological, and shoreline. Using the Multi-Criteria Decision Making (MCDM) approach, two CVI (CVI-50 and CVI-90) have been developed based on average and extreme conditions of the factors. Each CVI is then compared to a data-driven CVI, which is formed based on Probabilistic Principal Component Analysis (PPCA). Both MCDM and PPCA have been tied into geospatial analysis to assess the natural hazard vulnerability of six coastal counties in South Carolina. Despite traditional MCDM-based vulnerability assessments, where the final index is estimated based on subjective weighting methods or equal weights, this study employs an entropy weighting technique to reduce the individuals’ biases in weight assignment. Considering the multivariate nature of the coastal vulnerability, the validation results show both CVI-90 and PPCA preserve the vulnerability results from biophysical and socio-economic factors reasonably, while the CVI-50 methods underestimate the biophysical vulnerability of coastal hazards. Sensitivity analysis of CVIs shows that Charleston County is more sensitive to socio-economic factors, whereas in Horry County the physical factors contribute to a higher degree of vulnerability. Findings from this study suggest that the PPCA technique facilitates the high-dimensional vulnerability assessment, while the MCDM approach accounts more for decision-makers' opinions.