bluuebunny/crossref_metadata_2025_split huggingface dataset:
The spiritual contagion scale: A measure of beliefs in the transfer of metaphysical properties
Authors: Kim Jin , Newman George E. , Fedotova Natalie O. , Rozin Paul 
Published: November 2022

AbstractContagion is the belief that an entity's invisible or essential qualities can be transferred to a target. Researchers studying contagion have often distinguished between physical contagion (the perceived transfer of germs, toxins, and pathogens) and spiritual contagion (the perceived transfer of metaphysical properties such as spirits, essence, and moral characteristics). While sensitivity to physical contagion is a component of several existing scales, to date, there are no scales that measure sensitivity to spiritual contagion. Here, we develop and validate a measure of Spiritual Contagion Sensitivity (SCS), which considers positive, negative, and neutral aspects of spiritual contagion. We demonstrate discriminant validity from existing measures of physical contagion sensitivity, such as perceived vulnerability to disease and disgust sensitivity (Study 1). We demonstrate construct validity by showing the correlation between SCS and a variety of published findings in the literature for which spiritual contagion beliefs have been hypothesized to play a role (Study 2). Finally, we demonstrate predictive utility of the SCS scale by showing significant moderation of spiritual contagion effects from the literature (Studies 3A–3C).
Infective endocarditis in people who inject drugs: A scoping review of clinical guidelines
Authors: Selitsky Lea , Racha Savitha , Rastegar Darius , Olsen Yngvild 
Published: November 2022

AbstractBackgroundThe incidence of infective endocarditis (IE) among people who inject drugs (PWID) is rising worldwide. Multiple clinical guidelines differ on the management of this condition, and few guidelines comment on treatment for primary substance use disorder (SUD). A comprehensive comparison of these guidelines is lacking.ObjectivesTo perform a critical review identifying key differences in clinical guideline recommendations for treating IE among PWID, focusing on the inclusion of recommendations for SUD treatment and the presence of stigmatizing language.Eligibility CriteriaRecently published, English‐language, society‐developed clinical guidelines for the treatment of IE among PWID.Sources of EvidencePubMed, Google Scholar, and CINAHL Plus databases.Charting MethodsIn line with Arksey and O'Malley's framework, a scoping review was adapted using Joanna Briggs Institute and PRISMA‐ScR guidelines. Two reviewers independently performed database searches for clinical guidelines published between 2007 and 2020 that commented on the management of IE among PWID.ResultsTen clinical guidelines were included in the final analysis. Treatment recommendations varied with some societies proposing nonstandard care due to concern for return to drug use. Three guidelines include reference to addiction treatment. Only one guideline specifies the use of opioid agonist therapy for treating opioid use disorder and identifies the benefits of an addiction specialist consultation. Acute withdrawal management is not mentioned in any guideline. All guidelines utilized stigmatizing language to describe PWID.ConclusionsMost guidelines do not address SUD treatment, despite its effectiveness in reducing adverse health outcomes. Future guidelines should address SUD treatment using patient‐first language.
Recommendations on the follow‐up of patients with Gaucher disease in Spain: Results from a Delphi survey
Authors: Giraldo Pilar , Andrade‐Campos Marcio , Morales Montserrat ,   the SEGA (SEguimiento del paciente de GAucher, Gaucher patient follow‐up) Group
Published: November 2022

AbstractManagement of Gaucher disease (GD) is challenging due to its wide genotypic and phenotypic variability and changing clinical manifestations due to effective treatment. Sixteen face‐to‐face meetings with experts were held in order to discuss daily clinical practice and identify controversies regarding the management of GD. With this information, a questionnaire with 93 recommendations for different clinical scenarios was designed, and a Delphi survey among 86 physicians with experience in GD was conducted. Consensus was reached on 73 out of the 93 items. Recommendations on follow‐up of adult and pediatric patients were in line with current guidelines, and underscored the importance of a patient‐tailored approach. For the follow‐up of stable patients receiving long‐term treatment, consensus was reached on the importance of multidisciplinary care that involves pediatricians, internal medicine, and primary care, specialized radiologists, orthopedic surgeons, and hematologists when required. Degree of pain, use of painkillers and antidepressants, and quality of life should be evaluated at every follow‐up visit or at least once per year. In general, a closer follow‐up was recommended for untreated patients or patients who underwent a treatment change (every 3 months during the first year) and during pregnancy. For pregnant patients, hemostasis and risk of hemorrhage should be assessed, but no consensus was reached for initiation of treatment in asymptomatic pregnant patients. Lastly, recommendations on how to adapt GD management during a COVID‐19 pandemic were collected. This expert consensus may help decision‐making during the management of GD in specific clinical scenarios.
Risk Factors for Cerebrovascular Events in Moyamoya Angiopathy Using 4D Flow MRI: A Pilot Study
Authors: Wang Maoxue , Yang Yongbo , Zhang Wen , Zhou Fei , Zhang Xin , Zhang Jilei , Zhang Bing 
Published: November 2022

BackgroundLittle is known about internal carotid artery (ICA) hemodynamics in patients with moyamoya angiopathy (MMA) and its role in cerebrovascular events.PurposeTo characterize ICA hemodynamics in MMA patients by 4D flow MRI and investigate its relationship with cerebrovascular events.Study TypeProspective.SubjectsSeventy MMA patients (50 years old ± 9, 30 males).Field Strength/SequenceTime‐resolved three‐directional velocity encoded fast field echo sequence (4D flow) MRI, T1‐weighted fast field echo sequence, T2 weighted turbo spin echo sequence, diffusion weighted echo planar imaging; T2‐weighted fluid‐attenuated inversion recovery turbo spin echo sequence, susceptibility weighted fast field echo sequence, and time‐of‐flight MR angiography fast field echo sequence at 3.0T.AssessmentICA hemodynamics (maximum and average velocity [Vmax, Vavg], average blood flow [Flowavg], and wall shear stress) were analyzed based on 4D flow data. Cerebral infarction, defined as the occurrence of events, in 124 brain hemispheres was determined according to clinical symptoms and conventional brain MR imaging.Statistical TestsThe independent‐samples T test was used to evaluate differences in ICA hemodynamics between infarcted and non‐infarcted hemispheres. Binary logistic regression was performed to investigate the relationship between ICA hemodynamics and events. A P value < 0.05 was considered statistically significant.ResultsSixty‐one infarcted hemispheres (eight hemispheres with acute ischemic damage, 30 with chronic ischemic damage, and 23 with chronic hemorrhagic damage) had cerebrovascular events and 63 non‐infarcted hemispheres did not. The hemodynamic parameters in the infarcted hemispheres (Vmax: P < 0.001; Vavg: P = 0.003; and Flowavg: P = 0.004) were significantly lower than those in the non‐infarcted hemispheres. However, Vmax (P = 0.052), Vavg (P = 0.107), and Flowavg (P = 0.074) were not significantly different among hemispheres with acute ischemic lesions, chronic ischemic lesions and chronic hemorrhagic lesions. Vmax (odds ratio 3.033, 95% CI: 1.075–8.562) was independently associated with cerebrovascular events.Data ConclusionVmax maybe a higher risk factor of cerebrovascular events in MMA patients.Evidence Level2Technical Efficacy Stage3
Heavy metal removal from water using the metallogelation properties of a new glycolipid biosurfactant
Authors: Poirier Alexandre , Ozkaya Korin , Gredziak Julie , Talbot Delphine , Baccile Niki 
Published: November 2022

AbstractWater pollution by heavy metals is a problem in both western and developing countries. Heavy metal pollution can be associated with human activity, such as wastewaters from processing of ore mining, but also to simple contamination from metal‐rich soils. Whichever the case, chemical and physical methods are generally employed to depollute water. Since most chemicals are themselves polluting agents, there is an increasing interest in finding biobased and biodegradable alternative chemicals, both efficient in removing metals and benign to the environment. Biosurfactants are green chemicals produced by fermentation of yeasts and bacteria and with a good environmental score. Among many applications, this class of compounds has been used to remove heavy metals from contaminated soils. Within this framework, we propose a new mechanism of depolluting water using a glucolipid biosurfactant, G‐C18:1, composed of glucose (G) and a C18:1 fatty acid (oleic acid). This compound is able to form a metallogel by complexing cations in water, thus trapping heavy metals (Cu2+, Ni2+, Cr2+, and Co2+) in the gel phase. This mechanism allows to remove up to 95% for cobalt and 88 ± 10%, 80 ± 3%, and 59 ± 6% for Cu2+, Ni2+, and Cr2+, respectively. A dedicated structural study shows that this is possible because positively charged species induce gelation of G‐C18:1 through a micelle‐to‐wormlike phase transition, most likely driven by a charge neutralization process. This work shows that wise control of the nanoscale properties of green chemicals can strongly benefit to develop a sustainable future.
Dietary supplementation with a microencapsulated complex of thymol, carvacrol, and cinnamaldehyde improves intestinal barrier function in weaning piglets
Authors: Mo Kaibin , Yu Wengang , Li Jing , Zhang Yunxiao , Xu Ying , Huang Xianhui , Ni Hengjia 
Published: November 2022

AbstractBACKGROUNDThe authors previously prepared a microencapsulated complex of thymol, carvacrol, and cinnamaldehyde (MEEO). This study aimed to evaluate the effect of MEEO on the intestinal mucosal barrier and homeostasis in weaning piglets. A comparison of the effect of MEEO versus chlortetracycline (CTC) was performed in this study.RESULTSPiglets were divided into three groups – control (Con), MEEO, and CTC groups – and raised for 28 days. The results showed that MEEO significantly elevated the ratio of the villus height and the crypt depth in the jejunum and decreased the crypt depth in the ileum compared with the other groups (P < 0.05); it also upregulated the messenger ribonucleic acid (mRNA) expression of tight junction protein in the small intestine. Compared with the Con group, MEEO increased the concentration of secretory immunoglobulin A (sIgA), cathelicidin antimicrobial peptides (CAMP), and interleukin 10 (IL‐10), while decreasing the interleukin 1 beta (IL‐1β) concentration in both jejunal and ileal mucosa (P < 0.05). The mRNA expression of jejunal mucosal MUC1 and ileal mucosal MUC2 was increased in the MEEO group compared with the other groups (P < 0.05). Intestinal microbial analysis showed that dietary treatment had little impact on the ileal microbial structure. A significant rise in the genus Lactobacillus was, however, found in the MEEO group. There is a positive correlation between the Lactobacillus and sIgA, and between the Lactobacillus and CAMP, indicating that an improvement in the mucosal barrier function by the addition of MEEO may be associated with the proliferation of Lactobacillus.CONCLUSIONDietary supplementation with MEEO improves intestinal barrier function in weaning piglets, the effect of which was superior to CTC. © 2022 Society of Chemical Industry.
Effect of soaking and air‐resting on the phytochemical, antioxidant, and antimicrobial properties of Piper guineense (Schum and Thonn) seeds
Authors: Chiawa Sylvia C. , Attaugwu Roseline N. , Uvere Peter O. 
Published: November 2022

AbstractBACKGROUNDSoaking and air‐resting are processing steps in malting. This has been reported to increase metabolic and enzyme activities in rice paddy as a result of exposure of the grain to atmospheric oxygen. The present study evaluated the effect of soaking and air‐resting on the phytochemical composition of Piper guineense seeds. The seed extracts were prepared by: soaking the seeds in water for 4 h; air‐resting for 30, 60, 90, and 120 min; and re‐soaking for another 4 h. The out‐of‐steep seeds were milled and an extract was formed by tissue homogenization and maceration using ethanol. The phytochemical, antioxidant, and antibacterial properties of the seed extract were determined using standard methods.RESULTSThe alkaloid, flavonoid, saponin, tannin, and total phenol contents were 0.126–0.268, 0.091–0.172, 0.080–0.123, 0.00–0.107, and 0.447–0.908 g kg−1 respectively. The antioxidant properties (reducing power) of the seed extracts were concentration‐dependent and were in the range 1.08–3.24 g kg−1 at 8 mg mL−1, 1.14–3.47 g kg−1 at 16 mg mL−1, 1.30–3.35 g kg−1 at 24 mg mL−1, 1.26–3.11 g kg−1 at 32 mg mL−1, and 1.13–3.04 g kg−1 at 40 mg mL−1, respectively. The antibacterial activities against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa showed that, at 100 mg mL−1, the inhibition zone diameters of the seed extracts were in the range 10–23 mm.CONCLUSIONSoaking and air‐resting of P. guineense seeds increased the phytochemical components of the seeds. The extracts from the seeds air‐rested for 30 min showed the highest phytochemical contents and had the highest antioxidant and antimicrobial properties. © 2022 Society of Chemical Industry.
Survival outcomes after synchronous para‐aortic lymph node metastasis in colorectal cancer: A systematic review
Authors: Aylward Conor , Noori Jawed , Tyrrell Jack , O'sullivan Niall , Kavanagh Dara O. , Larkin John O. , Mehigan Brian J. , McCormick Paul H. , Kelly Michael E. 
Published: November 2022

AbstractBackgroundSynchronous para‐aortic lymph node metastasis (PALNM) in colorectal cancer (CRC) is a relatively rare clinical entity. There is a lack of consensus on management of these patients, and the role of para‐aortic lymph node dissection (PALND) remains controversial. This systematic review aims to describe the survival outcomes in colorectal cancer with synchronous PALNM when lymph node dissection is performed.MethodsA systematic review of Pubmed, Embase and Web of Science databases for PALND in CRC was performed. Studies including patients with synchronous PALNM undergoing resection with curative intent, published from the year 2000 onwards, were included.ResultsTwelve retrospective studies were included. Four studies reported survival outcomes for rectal cancer, two for colon cancer and six as colorectal. Survival outcomes for 356 patients were included. Average 5‐year overall survival (OS) was 22.4%, 33.9% and 37.7% in the rectal, colon and colorectal groups respectively. Three year OS in the groups was 53.6%, 46.2% and 65.7%.ConclusionThere remains a lack of quality data to confidently make recommendations regarding the management of synchronous PALNM in colon and rectal cancer cohorts. Retrospective data suggests a benefit in highly selective cohorts and therefore a case‐by‐case evaluation remains the standard of care.
Prediction of peptides retention behavior in reversed‐phase liquid chromatography based on their hydrophobicity
Authors: Al Musaimi Othman , Valenzo Oscar M. Mercado , Williams Daryl R. 
Published: November 2022

Hydrophobicity is an important physicochemical property of peptides and proteins. It is responsible for their conformational changes, stability, as well as various chemical intramolecular and intermolecular interactions. Enormous efforts have been invested to study the extent of hydrophobicity and how it could influence various biological processes, in addition to its crucial role in the separation and purification endeavor as well.Here, we have reviewed various studies that were carried out to determine the hydrophobicity starting from (i) simple amino acids solubility behavior, (ii) experimental approach that was undertaken in the reversed‐phase liquid chromatography mode, and ending with (iii) some examples of more advanced computational and machine learning models.
Endoscopic Versus Microscopic Type‐1 Tympanoplasty: A Meta‐Analysis of Randomized Trials
Authors: Crotty Thomas J. , Cleere Eoin F. , Keogh Ivan J. 
Published: November 2022

ObjectivesTotally endoscopic ear surgery is becoming increasingly utilized in otologic practice. Although the well‐established microscope‐assisted tympanoplasty remains the most common technique to repair a tympanic membrane defect, the merits of endoscopic approaches have been well‐documented. This systematic review and meta‐analysis compares the outcomes of endoscopic to microscopic tympanoplasty incorporating only randomized trials.Study DesignSystematic review and meta‐analysis.MethodsA comprehensive search of PubMed/MEDLINE, Scopus, Cochrane Library, and EMBASE was conducted. All randomized studies comparing endoscopic to microscopic tympanoplasty were collected according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis guidelines. Quality assessment was carried out utilizing the Risk of Bias 2.ResultsThe initial search identified 1711 studies, of which 9 met the inclusion criteria comprising of 540 patients (microscopic tympanoplasty 51.5%; endoscopic tympanoplasty 49.5%). The mean age was 32.5 years with a similar number of males (50.1%) and females (49.9%). Both endoscopic and microscopic groups had comparable outcomes with regards to graft success rate (RD 0.00; 95% confidence interval [CI], −0.04 to. 0.05; p = 0.87) and hearing improvement (MD 0.57 dB; 95% CI, −1.23 to 2.36; p = 0.54). A significantly shorter operative time was noted in the endoscopic group (MD, −24.73 min; 95% CI, −38.56 to −10.89; p = 0.0005).ConclusionOur results, assimilating level 1 evidence, demonstrates that endoscopic and microscopic‐assisted type‐1 tympanoplasty have similar outcomes in both graft success and hearing improvement, with endoscopic approaches yielding a shorter operative time.Level of Evidence1 Laryngoscope, 133:1550–1557, 2023
Microbially driven fate of terrigenous particulate organic matter in oceans
Authors: Zhang Lianbao , Chen Mingming , Zheng Yue , Wang Jianning , Xiao Xilin , Chen Xiaowei , Hu Chen , Shen Jiaming , Liu Jihua , Tang Kai , Xu Dapeng , Shi Qiang , Ning Xiaoyan , Thomas Helmuth , Qin Wei , Zhao Meixun , Jiao Nianzhi , Zhang Yao 
Published: November 2022

AbstractA long‐standing enigma in oceanography is why terrestrial organic matter is “missing” in the global ocean, despite the considerable discharge into it every year. Although some explanations, such as mineralogical composition, hydrodynamic processes, and priming effect, have been proposed, we hypothesize that the essential mechanism behind the missing organic matter is microbial processing, for which the underlying coupled geochemical, molecular, and genetic evidence is unknown. An ultra‐large‐volume, long‐term river–seawater stratified simulation system was constructed to unravel the microbially driven fate of terrigenous particulate organic matter (POM) in oceans. Analysis of combining the molecular with POM chemical composition data suggests that Bacteroidetes could act as pioneers in the processing of terrigenous POM in oceans, degrading high‐molecular‐weight, high‐carbon compounds such as polysaccharides. Remaining low‐molecular‐weight nitrogenous organic matter is subsequently degraded by Planctomycetes and Proteobacteria. Isotopic signals show that this preferential degradation causes a distinct “aging” effect of POM, and along with nitrification enhanced by remineralization, causes a decrease in the POM C : N ratio. Degradation of terrigenous POM and bacterial biomass biosynthesis leads to positive deviations in δ15N and δ13C. Relatively refractory hydrocarbons, aromatic compounds, and phenols are accumulated by microbial processes in this system. This study provides mechanistic insights into the missing chemical and isotopic signals and microbially driven fate of terrigenous POM in the ocean, with important implications for how riverine material input affects marine carbon and nitrogen cycling.
Glycidyl Cinnamate: Copolymerization with Glycidyl Ethers, In‐Situ NMR Kinetics, and Photocrosslinking
Authors: Maciol Kamil , Schüttner Sandra , Blankenburg Jan , Johann Tobias , Frey Holger 
Published: November 2022

AbstractThe copolymerization of glycidyl cinnamate (GC) as a hitherto non‐polymerizable, photoreactive epoxide structure to aliphatic polyether copolymers is described, using the monomer‐activated epoxide ring‐opening polymerization (MAROP). Ethoxyethyl glycidyl ether (EEGE) and GC are copolymerized employing triisobutylaluminum (i‐Bu3Al) as a catalyst and tetraoctylammonium bromide (NOctBr4) as an initiator. The amount of GC varies from 3 mol% to 100 mol%, which results in apparent molecular weights in the range of 2600 to 4600 g mol−1and dispersities (Đ)below 1.34. Studies of the microstructure by in‐situ1H NMR kinetics indicate a gradient‐like distribution of EEGE and GC (reactivity ratios:rEEGE= 0.28;rGC= 3.6), applying the ideal copolymerization model for evaluation. A tentative explanation relies on differing bond lengths in the respective epoxide rings, as suggested by density functional theory (DFT) calculations. Mild and selective cleavage of the acetal protecting groups of EEGE is achieved using the acidic ionic resin Dowex, leaving the GC ester bonds intact (Mn = 1900–3700 g mol−1,Đ <1.34). Thermal properties of the copolymers and the PGC homopolymer are investigated by differential scanning calorimetry (DSC). The crosslinking of P(G‐co‐GC) copolymers by UV irradiation allows hydrogel formation, which is confirmed by IR spectroscopy.
Tension‐Responsive Graphene Oxide Conductive Hydrogel with Robust Mechanical Properties and High Sensitivity for Human Motion Monitoring
Authors: Sun Peijie , Li Qiaoling 
Published: November 2022

PVA‐BB/GO‐Fe3+/agar hydrogels (BB is configured by 1:1 configuration of 0.04 mol L−1 boric acid solution and 0.04 mol L−1 borax solution) are designed with excellent mechanical and electrical properties due to their triple cross‐linked network, and they maintain stable performance in various tests, which is sufficient to support the use of hydrogels in multiple scenarios. Meanwhile, the tension responsiveness of the PVA‐BB/GO‐Fe3+/agar hydrogel allows it to rapidly transmit signal changes upon tension changes. Finally, maintaining increased energy dissipation and strength enhancement during the loading–unloading cycle provides the possibility of long, stable operation. In summary, it is believed that PVA‐BB/GO‐Fe3+/agar hydrogel has significant potential in the field of flexible sensors and is expected to be fabricated as a sensor for motion monitoring.