bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do women undertake interdisciplinary research more than men, and do self-citations bias observed differences?
Authors: Pinheiro Henrique , Durning Matt , Campbell David 
Published: May 2022

Abstract
Some studies have shown that women undertake interdisciplinary research more than men, whereas other studies have shown no difference by gender. Women have also been shown to self-cite less often than men, a difference at least partly mediated through differences in career stages and prior productivity. Existing evidence on gender-based differences in interdisciplinarity may therefore be biased. If interdisciplinarity is inferred from the disciplinary diversity of a paper’s cited references, a greater share of self-citations by men could decrease their measured interdisciplinarity relative to women. Such biases could lead to erroneous conclusions, because after correcting for self-citations one might uncover that women participate in interdisciplinary research equally to, or less than, men. Given that funding for interdisciplinary research is gaining in importance, obtaining accurate measurements of interdisciplinarity by gender is highly relevant for funders so that they can take appropriate action(s) in leveling the playing field across gender. For instance, evidence suggests women are sometimes advised not to participate in interdisciplinary research due to the risk it represents for their career progression. This study shows that a paper’s interdisciplinarity increases with the presence of female authors, accounting or not for self-citations in the interdisciplinarity measurement.
Annotated checklist of the vascular plants of Mount Kenya, East Africa
Authors: ZHOU YA-DONG , MWACHALA GEOFFREY , HU GUANG-WAN , WANG QING-FENG 
Published: May 2022

Mount Kenya, with its rich plant diversity, is among the famous tropical mountains in the world, and is the second highest mountain in Africa after Mount Kilimanjaro. An annotated checklist of the vascular plants of Mount Kenya was compiled through several approaches including our own collections from 2009 to 2018. A total of 1 545 vascular plants are found on Mount Kenya, including 1 481 indigenous and 64 exotics. The indigenous species are represented by nine lycophytes (five genera, two families), 129 ferns (56 genera, 20 families), three gymnosperms (three genera, two families), and 1 340 angiosperms (624 genera, 132 families). Trees constitute 9.92% of the flora, shrubs 15.99%, lianas 3.10%, climbers 4.45%, herbs 57.22%, lycophytes 0.61%, and ferns 8.70%. The two types of forest vegetation (lower montane wet forest and lower montane dry forest) have the highest and nival zone have the lowest species richness. In total, 18.96% of the species are distributed in Africa and other continents, 60.26% are endemic to Africa, 12.17% are endemic to Tropical East Africa, 3.17% are endemic to Kenya, 1.29% are endemic to Mount Kenya, and 4.14% are exotic plants. These results provide foundational data for further studies, and also provided support for the local government to formulate conservation policies.
Observations of the Turkana Jet and the East African Dry Tropics: The RIFTJet Field Campaign
Authors: Munday Callum , Engelstaedter Sebastian , Ouma Gilbert , Ogutu Geoffrey , Olago Daniel , Ong’ech Dennis , Lees Thomas , Wanguba Bonface , Nkatha Rose , Ogolla Clinton , Gàlgalo Roba Ali , Dokata Abdi Jillo , Kirui Erick , Hope Robert , Washington Richard 
Published: May 2022

Abstract
The Turkana low-level jet (LLJ) is an intrinsic part of the African climate system. It is the principle conduit for water vapor transport to the African interior from the Indian Ocean, and droughts in East Africa tend to occur when the jet is strong. The only direct observations of the Turkana jet come from manual tracking of pilot balloons in the 1980s. Now, modern reanalysis datasets disagree with one another over the strength of jet winds and underestimate the strength of the jet by 25%–75% compared to the pilot balloon data. This article gives an overview of a field campaign based in northwest Kenya—the Radiosonde Investigation for the Turkana Jet (RIFTJet)—which measured the Turkana jet for the first time in 40 years using modern technologies. Radiosonde data reveal a persistent low-level jet, which formed on every night of the campaign, with an average low-level maximum wind speed of 16.8 m s−1 at 0300 LT. One of the latest reanalysis datasets (ERA5) underestimates low-level wind speeds by an average of 24% (4.1 m s−1) at 0300 LT and by 33% (3.6 m s−1) at 1500 LT. The measurements confirm the role of the Turkana LLJ in water vapor transport: mean water vapor transport at Marsabit is 172 kg m s−1. The dataset provides new opportunities to understand regional dynamics, and to evaluate models in one of the most data-sparse regions in the world.
Enhanced Near-Inertial Waves and Turbulent Diapycnal Mixing Observed in a Cold- and Warm-Core Eddy in the Kuroshio Extension Region
Authors: Li Qi , Chen Zhaohui , Guan Shoude , Yang Haiyuan , Jing Zhao , Liu Yongzheng , Sun Bingrong , Wu Lixin 
Published: May 2022

Abstract
Shipboard observations of upper-ocean current, temperature–salinity, and turbulent dissipation rate were used to study near-inertial waves (NIWs) and turbulent diapycnal mixing in a cold-core eddy (CE) and warm-core eddy (WE) in the Kuroshio Extension (KE) region. The two eddies shed from the KE were energetic, with the maximum velocity exceeding 1 m s−1 and relative vorticity magnitude as high as 0.6f. The mode regression method was proposed to extract NIWs from the shipboard ADCP velocities. The NIW amplitudes were 0.15 and 0.3 m s−1 in the CE and WE, respectively, and their constant phase lines were nearly slanted along the heaving isopycnals. In the WE, the NIWs were trapped in the negative vorticity core and amplified at the eddy base (at 350–650 m), which was consistent with the “inertial chimney” effect documented in existing literature. Outstanding NIWs in the background wavefield were also observed inside the positive vorticity core of the CE, despite their lower strength and shallower residence (above 350 m) compared to the counterparts in the WE. Particularly, the near-inertial kinetic energy efficiently propagated downward and amplified below the surface layer in both eddies, leading to an elevated turbulent dissipation rate of up to 10−7 W kg−1. In addition, bidirectional energy exchanges between the NIWs and mesoscale balanced flow occurred during NIWs’ downward propagation. The present study provides observational evidence for the enhanced downward NIW propagation by mesoscale eddies, which has significant implications for parameterizing the wind-driven diapycnal mixing in the eddying ocean.

Significance Statement
We provide observational evidence for the downward propagation of near-inertial waves enhanced by mesoscale eddies. This is significant because the down-taking of wind energy by the near-inertial waves is an important energy source for turbulent mixing in the interior ocean, which is essential to the shaping of ocean circulation and climate. The anticyclonic eddies are widely regarded as a conduit for the downward near-inertial energy propagation, while the cyclonic eddies activity influencing the near-inertial waves propagation lacks clear cognition. In this study, enhanced near-inertial waves and turbulent dissipation were observed inside both cyclonic and anticyclonic eddies in the Kuroshio Extension region, which has significant implications for improving the parameterization of turbulent mixing in ocean circulation and climate models.
MRD in multiple myeloma: does CR really matter?
Authors: Paiva Bruno , San-Miguel Jesus , Avet-Loiseau Hervé 
Published: May 2022

Abstract
Multiple myeloma embodies the paradigm of the deeper the response, the longer the survival. However, results are conflicting regarding achievement of complete remission (CR) and minimal residual disease (MRD) negativity; some patients with persistent M protein have undetectable MRD. We reviewed the frequency of this discordance and outcomes of these patients. We spotlight possible explanations for and consequences of conflicting response criteria and suggest that MRD be assessed in patients achieving very good partial response or better in clinical trials.
GPVI expression is linked to platelet size, age, and reactivity
Authors: Veninga Alicia , Handtke Stefan , Aurich Konstanze , Tullemans Bibian M. E. , Brouns Sanne L. N. , Schwarz Silas L. , Heubel-Moenen Floor C. J. I. , Greinacher Andreas , Heemskerk Johan W. M. , van der Meijden Paola E. J. , Thiele Thomas 
Published: May 2022

Abstract
Platelets within one individual display heterogeneity in reactivity, size, age, and expression of surface receptors. To investigate the combined intraindividual contribution of platelet size, platelet age, and receptor expression levels on the reactivity of platelets, we studied fractions of large and small platelets from healthy donors separated by using differential centrifugation. Size-separated platelet fractions were perfused over a collagen-coated surface to assess thrombus formation. Multicolor flow cytometry was used to characterize resting and stimulated platelet subpopulations, and platelet age was determined based on RNA and HLA-I labeling. Signal transduction was analyzed by measuring consecutive phosphorylation of serine/threonine-protein kinase Akt. Compared with small platelets, large platelets adhered faster to collagen under flow and formed larger thrombi. Among the large platelets, a highly reactive juvenile platelet subpopulation was identified with high glycoprotein VI (GPVI) expression. Elevated GPVI expression correlated with high HLA-I expression, RNA content, and increased platelet reactivity. There was a stronger difference in Akt phosphorylation and activation upon collagen stimulation between juvenile and older platelets than between large and small platelets. GPVI expression and platelet reactivity decreased throughout platelet storage at 22°C and was better maintained throughout cold storage at 4°C. We further detected higher GPVI expression in platelets of patients with immune thrombocytopenia. Our findings show that high GPVI expression is a feature of highly reactive juvenile platelets, which are predominantly found among the large platelet population, explaining the better performance of large platelets during thrombus formation. These data are important for studies of thrombus formation, platelet storage, and immune thrombocytopenia.
Fibrin protofibril packing and clot stability are enhanced by extended knob-hole interactions and catch-slip bonds
Authors: Asquith Nathan L. , Duval Cédric , Zhmurov Artem , Baker Stephen R. , McPherson Helen R. , Domingues Marco M. , Connell Simon D. A. , Barsegov Valeri , Ariëns Robert A. S. 
Published: May 2022

Abstract
Fibrin polymerization involves thrombin-mediated exposure of knobs on one monomer that bind to holes available on another, leading to the formation of fibers. In silico evidence has suggested that the classical A:a knob-hole interaction is enhanced by surrounding residues not directly involved in the binding pocket of hole a, via noncovalent interactions with knob A. We assessed the importance of extended knob-hole interactions by performing biochemical, biophysical, and in silico modeling studies on recombinant human fibrinogen variants with mutations at residues responsible for the extended interactions. Three single fibrinogen variants, γD297N, γE323Q, and γK356Q, and a triple variant γDEK (γD297N/γE323Q/γK356Q) were produced in a CHO (Chinese Hamster Ovary) cell expression system. Longitudinal protofibril growth probed by atomic force microscopy was disrupted for γD297N and enhanced for the γK356Q mutation. Initial polymerization rates were reduced for all variants in turbidimetric studies. Laser scanning confocal microscopy showed that γDEK and γE323Q produced denser clots, whereas γD297N and γK356Q were similar to wild type. Scanning electron microscopy and light scattering studies showed that fiber thickness and protofibril packing of the fibers were reduced for all variants. Clot viscoelastic analysis showed that only γDEK was more readily deformable. In silico modeling suggested that most variants displayed only slip-bond dissociation kinetics compared with biphasic catch-slip kinetics characteristics of wild type. These data provide new evidence for the role of extended interactions in supporting the classical knob-hole bonds involving catch-slip behavior in fibrin formation, clot structure, and clot mechanics.
Application of Bayesian genomic prediction methods to genome-wide association analyses
Authors: Wolc Anna , Dekkers Jack C. M. 
Published: May 2022

AbstractBackgroundBayesian genomic prediction methods were developed to simultaneously fit all genotyped markers to a set of available phenotypes for prediction of breeding values for quantitative traits, allowing for differences in the genetic architecture (distribution of marker effects) of traits. These methods also provide a flexible and reliable framework for genome-wide association (GWA) studies. The objective here was to review developments in Bayesian hierarchical and variable selection models for GWA analyses.ResultsBy fitting all genotyped markers simultaneously, Bayesian GWA methods implicitly account for population structure and the multiple-testing problem of classical single-marker GWA. Implemented using Markov chain Monte Carlo methods, Bayesian GWA methods allow for control of error rates using probabilities obtained from posterior distributions. Power of GWA studies using Bayesian methods can be enhanced by using informative priors based on previous association studies, gene expression analyses, or functional annotation information. Applied to multiple traits, Bayesian GWA analyses can give insight into pleiotropic effects by multi-trait, structural equation, or graphical models. Bayesian methods can also be used to combine genomic, transcriptomic, proteomic, and other -omics data to infer causal genotype to phenotype relationships and to suggest external interventions that can improve performance.ConclusionsBayesian hierarchical and variable selection methods provide a unified and powerful framework for genomic prediction, GWA, integration of prior information, and integration of information from other -omics platforms to identify causal mutations for complex quantitative traits.
High-resolution detection of quantitative trait loci for seven important yield-related traits in wheat (Triticum aestivum L.) using a high-density SLAF-seq genetic map
Authors: Li Tao , Li Qiao , Wang Jinhui , Yang Zhao , Tang Yanyan , Su Yan , Zhang Juanyu , Qiu Xvebing , Pu Xi , Pan Zhifen , Zhang Haili , Liang Junjun , Liu Zehou , Li Jun , Yan Wuyun , Yu Maoqun , Long Hai , Wei Yuming , Deng Guangbing 
Published: May 2022

Abstract
Background
Yield-related traits including thousand grain weight (TGW), grain number per spike (GNS), grain width (GW), grain length (GL), plant height (PH), spike length (SL), and spikelet number per spike (SNS) are greatly associated with grain yield of wheat (Triticum aestivum L.). To detect quantitative trait loci (QTL) associated with them, 193 recombinant inbred lines derived from two elite winter wheat varieties Chuanmai42 and Chuanmai39 were employed to perform QTL mapping in six/eight environments.

Results
A total of 30 QTLs on chromosomes 1A, 1B, 1D, 2A, 2B, 2D, 3A, 4A, 5A, 5B, 6A, 6D, 7A, 7B and 7D were identified. Among them, six major QTLs QTgw.cib-6A.1, QTgw.cib-6A.2, QGw.cib-6A, QGl.cib-3A, QGl.cib-6A, and QSl.cib-2D explaining 5.96-23.75% of the phenotypic variance were detected in multi-environments and showed strong and stable effects on corresponding traits. Three QTL clusters on chromosomes 2D and 6A containing 10 QTLs were also detected, which showed significant pleiotropic effects on multiple traits. Additionally, three Kompetitive Allele Specific PCR (KASP) markers linked with five of these major QTLs were developed. Candidate genes of QTgw.cib-6A.1/QGl.cib-6A and QGl.cib-3A were analyzed based on the spatiotemporal expression patterns, gene annotation, and orthologous search.

Conclusions
Six major QTLs for TGW, GL, GW and SL were detected. Three KASP markers linked with five of these major QTLs were developed. These QTLs and KASP markers will be useful for elucidating the genetic architecture of grain yield and developing new wheat varieties with high and stable yield in wheat.
Distribution of FIB-4 index in the general population: analysis of 75,666 residents who underwent health checkups
Authors: Sugiyama Aya , Kurisu Akemi , E Bunthen , Ouoba Serge , Ko Ko , Rakhimov Anvarjon , Akita Tomoyuki , Harakawa Takayuki , Sako Toru , Koshiyama Makoto , Kumada Takashi , Tanaka Junko 
Published: May 2022

Abstract
Background
Fatty liver is frequently found in a general population, and it is critical to detect advanced fibrosis. FIB-4 index is considered a useful marker for evaluating liver fibrosis but the distribution of FIB-4 index in the general population remains unknown.

Methods
This cross-sectional study included residents who underwent ultrasonography at health checkups in Hiroshima or Iwate prefectures. The distribution of FIB-4 index in the total study population (N = 75,666) as well as in non-alcoholic fatty liver disease (NAFLD) populations (N = 17,968) and non-drinkers without fatty liver populations (N = 47,222) was evaluated. The distribution of aspartate aminotransferase (AST) levels, alanine aminotransferase (ALT) levels was also evaluated.

Results
The mean FIB-4 index in the total study population was 1.20 ± 0.63. FIB-4 index ≥ 2.67, which indicates a high risk of liver fibrosis, was found in 16.4% of those aged ≥ 70 years. In the NAFLD population, 58.1% of those in their 60 s and 88.1% of those ≥ 70 years met the criteria for referral to hepatologists by using the recommended FIB-4 index cutoff value (≥ 1.3). The mean FIB-4 index in the NAFLD population (1.12 ± 0.58) was significantly lower than in the non-drinkers without fatty liver (1.23 ± 0.63, p < 0.0001). The non-drinkers without fatty liver tended to have higher AST relative to ALT levels (60.0% with AST/ALT > 1.0), whereas the results in the NAFLD population were opposite (14.8% with AST/ALT > 1.0). AST > ALT resulted in a higher FIB-4 index in non-drinkers without fatty liver due to the nature of FIB-4 index formula.

Conclusions
The cutoff value of FIB-4 index (≥ 1.3) for triaging the elderly people with fatty liver for referral to hepatologists should be reconsidered to avoid over-referral. Due to the impact of age and characteristics of AST/ALT ratios, there is no prospect of using FIB-4 index for primary screening for liver fibrosis in a general population of unknown presence or absence of liver disease, even though it can be easily calculated using routine clinical indices. It is desired to develop a non-invasive method for picking up cases with advanced fibrosis latent in the general population.
Oropharyngeal dysphagia and associated factors among individuals living in nursing homes in northern Sweden in 2007 and 2013
Authors: Hägglund Patricia , Gustafsson Maria , Lövheim Hugo 
Published: May 2022

Abstract
Background
Swallowing difficulties in the oral cavity or pharynx (i.e., oropharyngeal dysphagia) are a common problem in the aging population, which may result in severe consequences, such as malnutrition, aspiration pneumonia, and mortality. Identifying oropharyngeal dysphagia and its associated factors is essential for establishing better healthcare policies in nursing homes. In this study, we aimed to describe the oropharyngeal dysphagia prevalence among nursing home residents, and to investigate the association between dysphagia and potentially related factors in a large survey of nursing home residents in Sweden, including individuals with various degrees of cognitive impairment. A secondary aim was to compare findings between years on oropharyngeal dysphagia and its associated factors.

Methods
This study is based on two cross-sectional surveys performed in 2007 and 2013, including 4,995 individuals living in nursing homes in the Region of Västerbotten, Sweden. Data were collected from caregivers’ reports regarding swallowing ability, nutritional status, chewing ability, and other baseline characteristics, such as cognitive function and activity of daily living (ADL). Data were analyzed using logistic regression models to calculate the odds of the association between oropharyngeal dysphagia and associated factors.

Results
Oropharyngeal dysphagia was reported in 14.9% (95% CI: 13.9–16.0) of the nursing home residents. An adjusted model revealed that oropharyngeal dysphagia was associated by severe cognitive impairment (OR: 1.56, 95% CI: 1.14–2.12) and ADL independence (OR: 0.81 95% CI: 1.82–2.66) among nursing home residents. We also identified the following as independently associated factors of dysphagia: reduced nutritional status (OR: 1.84, 95% CI: 1.49–2.27), artificial nutrition (OR: 6.33, 95% CI: 2.73–14.71), and clinical signs of aspiration (OR: 10.89, 95% CI: 8.40–14.12).

Conclusions
Oropharyngeal dysphagia was reported among approximately 15% nursing home residents and was associated with cognitive impairment and ADL capability. Furthermore, reduced nutritional status and artificial nutrition were also associated with oropharyngeal dysphagia. Implementing routine protocols in nursing homes may help detect oropharyngeal dysphagia and manage oropharyngeal dysphagia among residents.