bluuebunny/crossref_metadata_2025_split huggingface dataset:
MCDM-based RAT Selection method between LTE-D2D and IEEE 802.11
Authors: MAMADOU Ali , Chalhoub Gerard 
Published: November 2022

Abstract
Radio Access Technology (RAT) selection is an essential component in designing heterogeneous network coexistence to enable the diversity of future applications. In the 5G paradigm, many wireless technologies are available to ensure ubiquitous radio access. However, there are still open issues related to the decision-making process and Quality of Service (QoS) constraints consideration when it comes to selecting the most suitable wireless interface for a specific data transmission e.g. in Device-To-Device (D2D) communications. In this paper, we present MCDM-RAT: RAT Selection method between LTE-D2D and IEEE 802.11 formulated as a Multiple Criteria Decision Making (MCDM) problem with a decision data analysis mechanism that allows accurate network performance estimation in the decision making process. Full-stack network simulation results show the benefits of MCDM-RAT compared to baseline decision mechanisms. Our findings show the benefits of MCDM-RAT, under multiple network load conditions, in enhancing network performance perceived by end-users (in terms of delay, through-put, and data delivery rate), while considering simultaneously multiple QoS constraints.
Yield of MRI brain imaging in children with autism spectrum disorder
Authors: Byrne Dearbhla , Fisher Arie , Baker Louise , Twomey Eilish L , Gorman Kathleen M 
Published: November 2022

Abstract
Autism spectrum disorder (ASD) is a common neurodevelopmental condition. The American Academy of Paediatrics and American Academy of Neurology do not recommend routine brain magnetic resonance imaging (MRI) in the assessment of ASD. The need for a brain MRI should be decided on atypical features in the clinical history and examination. However, many physicians continue to use MRI brain routinely in the assessment process.
We performed a retrospective review of indications for requesting MRI brain in our institution over a 5-year period to determine. The aim was to was to identify the yield of MRI imaging in children with ASD and calculate the prevalence of significant neuroimaging abnormalities in children with ASD and identify clinical indications for neuroimaging
One hundred and eighty-one participants were analysed. An abnormal brain MRI was identified in 7.2% (13/181). Abnormal MRI brain was more likely with an abnormal neurological examination (OR 33.1, p=0.001) or genetic/metabolic abnormality (OR 20, p=0.02). In contrast, abnormal MRI was not shown to be more likely in children with a variety of other indications such as behavioural issues and developmental delay.
Thus, our findings support that MRI should not be a routine investigation in ASD, without additional findings. The decision to arrange MRI brain should be made on a case-by-case basis following careful evaluation of potential risks and benefits. The impact of any findings on the management course of the child should be considered prior to arranging imaging.
MicroRNA-598 inhibition ameliorates LPS-induced acute lung injury in mice through upregulating Ebf1 expression
Authors: Zhao Qi , He Lei , Zhang Junwu , Li Hong , Li Wanying , Zhou Zhihui , Li Yuanyuan 
Published: November 2022

Abstract
Acute lung injury is a critical acute respiratory distress syndrome (ARDS) with high morbidity and mortality. MicroRNAs (miRNAs) have been demonstrated to play important roles regulating acute lung injury development. In this study, we found that the expression of miR-598 was significantly upregulated in the lung tissues of mice with LPS-induced acute lung injury. Both loss-of function and gain-of-function studies were performed to evaluate the function of miR-598 in acute lung injury. The results showed that inhibition of miR-598 attenuated inflammatory response, oxidative stress and lung injury in mice treated with LPS, while overexpression of miR-598 exacerbated the LPS-induced acute lung injury. Mechanistically, transcription factor Early B-cell Factor-1 (Ebf1) was predicted and validated as a downstream target of miR-598. Overexpression of Ebf1 attenuated LPS-induced production of inflammatory cytokine TNF-α and IL-6, ameliorated LPS-induced oxidative stress, promoted proliferation and inhibited apoptosis in murine lung epithelial − 15 (MLE-15) cells. Moreover, we demonstrated that Ebf1 knockdown abolished the protective effect of miR-598 inhibition in MLE-15 cells. In summary, miR-598 inhibition ameliorates LPS-induced acute lung injury in mice through upregulating Ebf1 expression, which might provide potential therapeutic treatment for acute lung injury.
Entanglement generation by strong coupling between surface lattice resonance and exciton in an Al nanoarray coated WS2 quantum emitter
Authors: Shi Xiaoqi , Wang Zhihang , Xiao Jiamin , Li Lingyao , Wei Shibo , Guo Zhicheng , Wang Yi , Wang Wenxin 
Published: November 2022

Abstract
Strong light-matter interaction plays a central role in realizing quantum photonic technologies. The entanglement state, which results from the hybridization of excitons and cavity photons, forms the foundation of quantum information science. In this work, an entanglement state is achieved by manipulating the mode coupling between surface lattice resonance and quantum emitter into the strong coupling regime. At the same time, a Rabi splitting of 40 meV is observed. A full quantum model based on the Heisenberg picture is used to describe this unclassical phenomenon, and it perfectly explains the interaction and dissipation process. In addition, the observed concurrency degree of the entanglement state is 0.5, presenting the quantum non-locality. This work effectively contributes to the understanding of non-classical quantum effects arising from strong coupling and will intrigue more interesting potential applications in quantum optics.
ADSC-derived exosomes attenuate myocardial infarction injury by promoting miR-205- mediated cardiac angiogenesis
Authors: Wang Tingting , Li Tao , Niu Xiaolin , Hu Lang , Cheng Jin , Guo Dong , Ren He , Zhao Ran , Ji Zhaole , Liu Pengyun , Li Yan , Guo Yanjie 
Published: November 2022

Abstract
Background: Acute myocardial infarction (MI) is a major health problem and is the leading cause of death worldwide. Myocardial apoptosis induced by myocardial infarction injury is involved in the pathophysiology of heart failure. Therapeutic stem cell therapy has the potential to be an effective and favorable treatment for ischemic heart disease. Exosomes derived from stem cells have been shown to effectively repair MI injury-induced cardiomyocyte damage. However, the cardioprotective benefits of adipose tissue-derived mesenchymal stem cell (ADSC)-Exos remain unknown. This study aimed to investigate the protective effects of exosomes from ADSC on the hearts of MI-treated mice and to explore the underlying mechanisms.
Methods: Cellular and molecular mechanisms were investigated using cultured ADSCs. On C57BL/6J mice, we performed myocardial MI or sham operations and assessed cardiac function, fibrosis, and angiogenesis 4 weeks later. Mice were intramyocardially injected with ADSC-Exos or vehicle-treated ADSCs after 25 min following the MI operation.
Results: Echocardiographic experiments showed that ADSC-Exos could significantly improve left ventricular ejection fraction, whereas ADSC-Exos administration could significantly alleviate MI-induced cardiac fibrosis. Additionally, ADSC-Exos treatment has been shown to reduce cardiomyocyte apoptosis while increasing angiogenesis. Molecular experiments found that exosomes extracted from ADSCs can promote the proliferation and migration of microvascular endothelial cells, facilitate angiogenesis, and inhibit cardiomyocytes apoptosis through miRNA-205. We then transferred isolated exosomes from ADSCs into MI-induced mice and observed decreased cardiac fibrosis, increased angiogenesis, and improved cardiac function. We also observed increased apoptosis and decreased expression of hypoxia-inducible factor-1α and vascular endothelial growth factor in HMEC-1 transfected with a miRNA-205 inhibitor.
Conclusion: In summary, these findings show that ADSC-Exos can alleviate cardiac injury and promote cardiac function recovery in MI-treated mice via the miRNA-205 signaling pathway. ADSC-Exos containing miRNA205 have a promising therapeutic potential in MI-induced cardiac injury.
Patella component diameters of 38 mm and up might be associated with higher revision rates after patella resurfacing.
Authors: Jungwirth-Weinberger Anna , Rueckl Kilian , Bechler Ulrich , Hanreich Carola , Rueckl Stefan , Boettner Friedrich 
Published: November 2022

Abstract
Purpose
Patellar resurfacing in Total knee arthroplasty is considered standard in the United States. Complications of patella resurfacing include aseptic loosening or patella fractures possibly resulting in loss of the extensor mechanism.
The goal of this study was to evaluate the Genesis II patella button and to report its outcome and complications.
Material & Methods
Between 01/2010 and 08/2016 the Genesis II patella button was implanted in 1,056 patients (267 men and 550 women) by the senior author at the authors’ institution as part of a posterior stabilized total knee arthroplasty.
Results
Of 1,056 cases 35 cases (14 women, 15 men, 5 bilateral, 3.3%) showed early loosening of the Genesis patella button at a mean 52.5 months postoperatively. Buttons of 38mm and larger patella components showed a significantly higher loosening rate than the 29, 32, 35mm buttons (p<0.01). Mean BMI of patients identified with aseptic loosening was 31.7kg/m2, mean age at time of revision surgery was 63.3 years. All of the patients with loosening of the patella button required revision surgery; in 33 cases an exchange of the button was performed, in two cases a removal of the button and patellar bone grafting was indicated. No complications occurred after revision surgery.
Conclusion
The current study reports a 3.3% patella loosening rate in the short follow up for the Genesis II patella button. Button 35mm and larger showed a significantly higher revision rate than smaller buttons and the authors advise caution when using large diameter patella components.
Optimized back propagation neural network for DDoS attack detection in the cloud environment
Authors: Arunadevi M. , Sathya V. 
Published: November 2022

Abstract
Cloud computing facilitates users with on-demand services over the Internet. Depending on demand, cloud services are frequently utilized as private or public data forums, and the rise in usage has raised security issues. The distributed denial of service (DDoS) attack is one of these security risks that affect cloud computing services. In this work, the optimized back propagation neural network (BPNN) is proposed to detect DDoS attacks in the cloud environment. The proposed optimized BPNN is used artificial plant optimization (APO) algorithm for optimizing the weights and bias of the connections. The proposed APO-BPNN detection system is evaluated using four datasets namely, NSL-KDD, ISCX-IDS 2012, UNSW-NB15, and CIC-IDS 2017. The experiments show that the performance of the proposed APO-BPNN detection system is better than the system based on variant BPNN and state-of-the-art techniques.
Transpiration by sap flow Thermal Dissipation Method: applicability to a hedgerow olive orchard
Authors: Ferrara Rossana Monica 
Published: November 2022

Abstract

The climate change requires thrifty use of water resources in agriculture since irrigation is became common also for those crops like olive orchard that were traditionally grown in rainfed conditions. The water requirement is imperative in semi-arid conditions of the Mediterranean basin especially if the olive orchards are cultivated in super high density. For a correct irrigation scheduling, methods to measure transpiration (Tr) at plant level are used. Among the most spread methods to determine Tr, the thermal dissipation method (TDM) has been applied on a hedgerow olive orchard considering: (i) species-specific local calibration, (ii) wound effects, (iii) azimuth correction, and (iv) radial gradient corrections. The performances of the corrected TDM method have been evaluated with respect an independent method, the water balance at weekly scale. If any correction nor specific calibration is carried out, the underestimation of the actual transpiration calculated by TDM was of about − 18% with respect to the water balance method.
Estimating gabion weir oxygen transfer with data mining
Authors: Tiwari Nand Kumar , Luxmi K.M. , Ranjan Subodh 
Published: November 2022

Abstract
Conventionally, impermeable weirs are employed for retaining, measuring, and regulating the water in the river. Today, alternative devices are more predominantly in vogue, which are made of locally available materials called gabion weirs chosen because the latter can better fulfill ecological needs due to their porous nature. Dissolved oxygen (D.O.) is one of the significant determinants for assessing the character of water bodies. This study mainly focuses on improving the estimation of the gabion oxygen transfer efficiency (OTE20) to enhance its efficacy. The backpropagation neural network (BPNN), adaptive neuro-fuzzy inference system (ANFIS), and multi-variant linear and nonlinear regression (MVLR and MVNLR) are developed with experimental data to estimate the OTE20 and their results are compared. In terms of statistical metrics, the BPNN has proved to be the best-performing model. At the same time, triangular membership function (mf)-based ANFIS is the second-best performing model. Nevertheless, other applied mf-based ANFIS, MVLR, and MVNLR are giving a comparable performance. Input variable discharge per unit width (q) is the most crucial parameter in the computation of the OTE20, followed by the gabion mean size (d50). Major challenges are found in computing porosity of the gabion materials and optimal parameters of proposed data mining techniques.
Assessing Myocardial Involvement in Systemic Lupus Erythematosus Patients
without Cardiovascular Symptoms by Technetium-99m-sestamibi
Myocardial Perfusion Imaging: A Correlation Study on NT-proBNP
Authors: Shao Kejing , Yuan Fenghong , Chen Fei , Wang Jianfeng , Shao Xiaoliang , Zhang Feifei , Zhu Bao , Wang Yuetao 
Published: November 2022

Background:
In patients with systemic lupus erythematosus (SLE), myocardial involvement
is the third leading course of death after lupus nephropathy (LN) and infections. Previous autopsy studies
have demonstrated a high incidence of cardiovascular abnormalities in the myocardium. However,
the patients with typical symptoms are far much fewer than expected from post-mortem examinations.

Objectives:
The current study aimed to evaluate the technetium-99m-sestamibi (99mTc-MIBI) gated
myocardial perfusion imaging (GMPI) characteristics of lupus patients without cardiovascular symptoms,
and the relationships between GMPI characteristics and biochemical markers of myocardial injury,
and to explore the role of GMPI in assessing myocardial involvement.

Methods:
Thirty patients were studied with rest myocardial perfusion imaging, and summed rest score
(SRS), summed motion score (SMS), and summed thickening score (STS) were calculated automatically.
Biomarkers, including N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and
creatine-kinase-MB (CK-MB), were detected simultaneously. GMPI parameters, LV functions and
biomarkers were compared between two NT-proBNP groups. The relationships between these parameters
were studied by correlation analysis.

Results:
SMS, STS, and glomerular filtration rate (eGFR) were the main influencing factors of NTproBNP
level (p = 0.001, <0.001, 0.042, respectively). Thirteen patients with an evaluated concentration
of NT-proBNP had the lower left ventricular ejection fraction (LVEF), peak filling rate (PFR),
eGFR and higher levels of CK-MB (in all comparisons, p < 0.05), and SRS was the only influencing
factor of NT-proBNP (p = 0.007). Within thirteen patients with SRS≥2, there was a significant correlation
between SRS and NT-proBNP (p < 0.001).

Conclusion:
99mTc-MIBI GMPI could evaluate the left ventricular function and prompt the cardiomyocyte
function at the cellular level. SMS and STS were the main influencers for plasma NT-proBNP,
and SRS was the independent factor for elevated NT-proBNP. This radionuclide imaging method
could provide additional diagnostic information on myocardial involvement in patients with SLE.
Non-surgical Treatment of a Late Adolescent Patient with Skeletal Class II Malocclusion Using Clear Aligners: A Case Report
Authors: Robertson Lindsay J. , El-Bialy Tarek 
Published: November 2022

Background/Introduction:
There are a variety of treatment modalities for orthodontic treatment of patients with skeletal Class II malocclusions in late adolescence. These treatment modalities may include surgical intervention, camouflage treatment, functional appliances, extraction of teeth, and/or Class II elastics mechanics. Most Class II mechanics produce retroclination of the upper incisors and proclination of lower incisors. These dentoalveolar effects limit the possibility for forward mandibular projection/growth, hence minimizing skeletal improvement.

Case Presentation:
To present a unique case report that was treated with a new perspective in maximizing skeletal improvement in a late adolescent male with skeletal Class II malocclusion and deep overbite.
A 15-year-old male presented with a skeletal Class II pattern due to mandibular retrognathism was treated with non-extraction, non-surgical technique using clear aligners in two phases. Phase 1 was designed to decompensate the compensated inclination of his anterior teeth, and phase II was planned to correct his skeletal and dental Class II malocclusion/mal relation. Results: Maxillary incisors decompensation of the inclination of the upper and lower incisors and posterior teeth intrusion allowed forward mandibular projection that led to skeletal and dental correction of his malocclusion and improvement of his chin forward projection.

Conclusion:
This case report shows successful treatment of a Class II malocclusion in alate adolescent male. This method could perhaps be used for similar cases, avoiding the need to extract teeth or include surgical intervention.
Landscape Analysis of Quercetin: A Potential Candidate Against SARSCoV-
2
Authors: Niaz Kamal , Shafqat Furqan , Shafeeq Ur Rehman  , Nasir Omazia , Sarwar Ayesha 
Published: November 2022

Abstract:
Fruit, vegetables, and green tea contain quercetin (a flavonoid). Some of the diet's most significant
sources of quercetin are apples, onions, tomatoes, broccoli, and green tea. Antioxidant, anticancer,
anti-inflammatory, antimicrobial, antibacterial, and anti-viral effects have been studied of quercetin. The
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, ribonucleic acid (RNA) polymerase,
and other essential viral life-cycle enzymes are all prevented from entering the body by quercetin.
Despite extensive in vitro and in vivo investigations on the immune-modulating effects of quercetin and
vitamin C treatment. 3-methyl-quercetin has been shown to bind to essential proteins necessary to convert
minus-strand RNA into positive-strand RNAs, preventing the replication of viral RNA in the cytoplasm.
Quercetin has been identified as a potential SARS-CoV-2 3C-like protease (3CLpro) suppressor in recent
molecular docking studies and in silico assessment of herbal medicines. It has been demonstrated that
quercetin increases the expression of heme oxygenase-1 through the nuclear factor erythroid-related factor
2 (Nrf2) signal network. Inhibition of heme oxygenase-1 may increase bilirubin synthesis, an endogenous
antioxidant that defends cells. When human gingival fibroblast (HGF) cells were exposed to lipopolysaccharide
(LPS), inflammatory cytokine production was inhibited. The magnesium (Mg+2) cation
complexation improves quercetin free radical scavenging capacity, preventing oxidant loss and cell death.
The main objective of this paper is to provide an overview of the pharmacological effects of quercetin, its
protective role against SARS-CoV-2 infection, and any potential molecular processes.
Associations Among Multimorbid Conditions in Hospitalized Middle-aged and Older Adults in China: Statistical Analysis of Medical Records
Authors: Zhang Yan , Chen Chao , Huang Lingfeng , Liu Gang , Lian Tingyu , Yin Mingjuan , Zhao Zhiguang , Xu Jian , Chen Ruoling , Fu Yingbin , Liang Dongmei , Zeng Jinmei , Ni Jindong 
Published: November 2022

Background
Multimorbidity has become a new challenge for medical systems and public health policy. Understanding the patterns of and associations among multimorbid conditions should be given priority. It may assist with the early detection of multimorbidity and thus improve quality of life in older adults.

Objective
This study aims to comprehensively analyze and compare associations among multimorbid conditions by age and sex in a large number of middle-aged and older Chinese adults.

Methods
Data from the home pages of inpatient medical records in the Shenzhen National Health Information Platform were evaluated. From January 1, 2017, to December 31, 2018, inpatients aged 50 years and older who had been diagnosed with at least one of 40 conditions were included in this study. Their demographic characteristics (age and sex) and inpatient diagnoses were extracted. Association rule mining, Chi-square tests, and decision tree analyses were combined to identify associations between multiple chronic conditions.

Results
In total, 306,264 hospitalized cases with available information on related chronic conditions were included in this study. The prevalence of multimorbidity in the overall population was 76.46%. The combined results of the 3 analyses showed that, in patients aged 50 years to 64 years, lipoprotein metabolism disorder tended to be comorbid with multiple chronic conditions. Gout and lipoprotein metabolism disorder had the strongest association. Among patients aged 65 years or older, there were strong associations between cerebrovascular disease, heart disease, lipoprotein metabolism disorder, and peripheral vascular disease. The strongest associations were observed between senile cataract and glaucoma in men and women. In particular, the association between osteoporosis and malignant tumor was only observed in middle-aged and older men, while the association between anemia and chronic kidney disease was only observed in older women.

Conclusions
Multimorbidity was prevalent among middle-aged and older Chinese individuals. The results of this comprehensive analysis of 4 age-sex subgroups suggested that associations between particular conditions within the sex and age groups occurred more frequently than expected by random chance. This provides evidence for further research on disease clusters and for health care providers to develop different strategies based on age and sex to improve the early identification and treatment of multimorbidity.