bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging polymeric biomaterials and manufacturing techniques in regenerative medicine
Authors: Xia Dan , Chen Jiatian , Zhang Zhongyang , Dong Mingdong 
Published: February 2022

AbstractThe current demand for patients’ organ and tissue repair and regeneration is continually increasing, where autologous or allograft is the golden standard treatment in the clinic. However, due to the shortage of donors, mismatched size and modality, functional loss of the donor region, possible immune rejection, and so forth, the application of auto‐/allo‐grafts is frequently hindered in many cases. In order to solve these problems, artificial constructs structurally and functionally imitating the extracellular matrix have been developed as substitutes to promoting cell attachment, proliferation, and differentiation, and ultimately forming functional tissues or organs for better tissue regeneration. Particularly, polymeric materials have been widely utilized in regenerative medicine because of their ease of manufacturing, flexibility, biocompatibility, as well as good mechanical, chemical, and thermal properties. This review presents a comprehensive overview of a variety of polymeric materials, their fabrication methods as well applications in regenerative medicine. Finally, we discussed the future challenges and perspectives in the development and clinical transformation of polymeric biomaterials.
Risk stratification for relapsed/refractory classical Hodgkin lymphoma integrating pretransplant Deauville score and residual metabolic tumor volume
Authors: Yhim Ho‐Young , Eshet Yael , Metser Ur , Lajkosz Katherine , Cooper Matthew , Prica Anca , Kukreti Vishal , Bhella Sita , Lang Noémie , Xu Wei , Rodin Danielle , Hodgson David , Tsang Richard , Crump Michael , Kuruvilla John , Kridel Robert 
Published: February 2022

AbstractPretransplant Deauville score (DS) is an imaging biomarker used for risk stratification in relapsed/refractory classical Hodgkin lymphoma (cHL). However, the prognostic value of residual metabolic tumor volume (rMTV) in patients with DS 4–5 has been less well characterized. We retrospectively assessed 106 patients with relapsed/refractory cHL who underwent autologous stem cell transplantation. Pretransplant DS was determined as 1–3 (59%) and 4–5 (41%), with a markedly inferior event‐free survival (EFS) in patients with DS 4–5 (hazard ratio [HR], 3.14; p = .002). High rMTV41% (rMTVhigh, ≥4.4 cm3) predicted significantly poorer EFS in patients with DS 4–5 (HR, 3.70; p = .014). In a multivariable analysis, we identified two independent factors predicting treatment failure: pretransplant DS combined with rMTV41% and disease status (primary refractory vs. relapsed). These two factors allow to stratify patients into three groups with divergent 2‐year EFS: 89% for low‐risk (51%; relapsed disease and either pretransplant DS 1–3 or DS 4–5/rMTVlow; HR 1), 65% for intermediate‐risk (28%; refractory disease and either DS 1–3 or DS 4–5/rMTVlow; HR 3.26), and 45% for high‐risk (21%; DS 4–5/rMTVhigh irrespective of disease status; HR 7.61) groups. Pretransplant DS/rMTV41% combination and disease status predict the risk of post‐transplant treatment failure and will guide risk‐stratified approaches in relapsed/refractory cHL.
Fully Conjugated Tetraoxa[8]circulene‐Based Porous Semiconducting Polymers
Authors: Fritz Patrick W. , Chen Tianyang , Ashirov Timur , Nguyen Anh‐Dao , Dincă Mircea , Coskun Ali 
Published: February 2022

AbstractTetraoxa[8]circulenes (TOCs) are a class of hetero[8]circulenes featuring a planar cyclooctatetraene core with a mixed aromatic/antiaromatic motif that governs their electronic properties. Polymeric TOCs (pTOCs) have been the subject of several computational simulations because they are predicted to be low‐band‐gap semiconductors, but they have not been available synthetically yet. Here, we report the first example of pTOCs, a new family of porous semiconductors, synthesized under ionothermal conditions through the intermolecular cyclization of 1,4,5,8‐anthracene tetrone. pTOCs are porous, with surface areas up to 1656 m2 g−1, and exhibit light‐switchable and tunable semiconducting properties.
Co‐Assembly Induced Solid‐State Stacking Transformation in Amino Acid‐Based Crystals with Enhanced Physical Properties
Authors: Ji Wei , Yuan Hui , Xue Bin , Guerin Sarah , Li Hui , Zhang Lei , Liu Yanqing , Shimon Linda J. W. , Si Mingsu , Cao Yi , Wang Wei , Thompson Damien , Cai Kaiyong , Yang Rusen , Gazit Ehud 
Published: February 2022

AbstractThe physical characteristics of supramolecular assemblies composed of small building blocks are dictated by molecular packing patterns in the solid‐state. Yet, the structure–property correlation is still not fully understood. Herein, we report the unexpected cofacial to herringbone stacking transformation of a small aromatic bipyridine through co‐assembly with acetylated glutamic acid. The unique solid‐state structural transformation results in enhanced physical properties of the supramolecular organizations. The co‐assembly methodology was further expanded to obtain diverse molecular packings by different bipyridine and acetylated amino acid derivatives. This study presents a feasible co‐assembly approach to achieve the solid‐state stacking transformation of supramolecular organization and opens up new opportunities to further explore the relationship between molecular arrangement and properties of supramolecular assemblies by crystal engineering.
Distale Ruthenaelektro‐katalysierte meta‐C−H‐Bromierung mit wässriger HBr
Authors: Wang Yulei , Simon Hendrik , Chen Xinran , Lin Zhipeng , Chen Shan , Ackermann Lutz 
Published: February 2022

AbstractWährend elektrochemische ortho‐selektive C−H‐Aktivierungen bereits etabliert sind, bleiben die distalen C−H‐Aktivierungen weiterhin unterrepräsentiert. Hiermit beschreiben wir eine meta‐C−H‐Aktivierung. Die Bromierung der abgelegenen C−H‐Bindung wurde in einer ungeteilten Zelle unter Verwendung von RuCl3⋅3 H2O und wässriger HBr realisiert. Die Elektrohalogenierung verläuft ohne die Zugabe eines zusätzlichen Liganden und unter elektrolytfreien Bedingungen. Bemerkenswerterweise wurden Pyrazolylarene zum ersten Mal meta‐selektiv am Benzoidfragment und nicht am elektronenreichen Pyrazolring funktionalisiert. Mechanistische Studien legen die Bildung eines Ruthenazyklus nahe mit nachfolgendem Ligand‐zu‐Ligand‐Wasserstoff‐Transfer (LLHT), welcher schließlich das bromierte Produkt bildet.
Non‐parametric local capability indices for industrial planar manufacts: An application to the etching phase in the microelectronic industry
Authors: Borgoni Riccardo , Farace Vincenzo Emanuele , Zappa Diego 
Published: February 2022

AbstractProcess capability indices are routinely used to estimate the mean‐variability performance of industrial products with respect to both targets and specification limits. However, when the target variable is defined over a planar surface of a manufact, it is relevant to assess the capability of the production process locally, that is, at any spatial location of the surface, in particular if the manufact has to be split into pieces to obtain single production items. In this article, focusing on the specification introduced by Clements [Qual Prog., 22, 95–100], we suggest an approach based on additive quantile models to estimate, in a Bayesian paradigm, the index locally. We demonstrate its use in the context of the etching phase of the integrated circuit fabrication process. Since capability of etching processes is typically assessed for batches of wafers, we also propose two algorithms based on resampling to perform local capability analysis at the lot level.
Process monitoring framework for cross‐flow diafiltration‐based virus‐like particle disassembly: Tracing product properties and filtration performance
Authors: Hillebrandt Nils , Vormittag Philipp , Dietrich Annabelle , Hubbuch Jürgen 
Published: February 2022

AbstractVirus‐like particles (VLPs) are an emerging biopharmaceutical modality with great potential as a platform technology. VLPs can be applied as gene therapy vectors and prophylactic or therapeutic vaccines. For non‐enveloped VLPs, recombinant production of the protein subunits leads to intracellular self‐assembly. The subsequent purification process includes VLP dis‐ and reassembly which aim at removing encapsulated impurities and improving particle properties. Filtration‐based separation and processing has proven successful for VLPs but requires large product quantities and laborious experiments in early development stages. Both challenges can be tackled by implementation of process analytical technology (PAT) to efficiently obtain extensive process information. In this study, an existing PAT setup was extended to comprehensively monitor the diafiltration‐based disassembly of hepatitis B core antigen (HBcAg) VLPs. Process‐related signals were monitored in‐line, while product‐related signals, such as ultraviolet light (UV) spectra as well as static and dynamic light scattering (SLS and DLS), were monitored on‐line. The applicability of the sensors for disassembly monitoring was evaluated under varying processing conditions. HBcAg VLP subunit concentrations were accurately predicted based on UV data using ordinary and partial least squares regression models (Q2 from 0.909 to 0.976). DLS data were used for aggregation monitoring while the SLS intensity qualitatively reflected the disassembly progress.
Optimized prodigiosin production with Pseudomonas putida KT2440 using parallelized noninvasive online monitoring
Authors: Brehl Carl , Brass Hannah U. C. , Lüchtrath Clara , Böckmann Lukas , Ihling Nina , Classen Thomas , Pietruszka Jörg , Büchs Jochen 
Published: February 2022

AbstractThe red pigment prodigiosin is of high pharmaceutical interest, due to its potential applications as an antitumor drug and antibiotic agent. As previously demonstrated, Pseudomonas putida KT2440 is a suitable host for prodigiosin production, as it exhibits high tolerance toward the antimicrobial properties of prodigiosin. So far, prodigiosin concentrations of up to 94 mg/L have been achieved in shake flask cultivations. For the characterization and optimization of the prodigiosin production process, the scattered light of P. putida and fluorescence of prodigiosin was measured. The excitation and emission wavelengths for prodigiosin measurement were analyzed by recording 2D fluorescence spectra. The strongest prodigiosin fluorescence was obtained at a wavelength combination of 535/560 nm. By reducing the temperature to 18 °C and using 16 g/L glucose, the prodigiosin concentration was more than doubled compared with the initial cultivation conditions. The obtained results demonstrate the capabilities of parallelized microscale cultivations combined with noninvasive online monitoring of fluorescence for rapid bioprocess development, using prodigiosin as a molecule of current biotechnological interest.
Comparative Study of the Essential Oil and Hydrosol Composition of Sweet Wormwood (Artemisia annuaL.) from Serbia
Authors: Aćimović Milica , Jeremić Jovana Stanković , Todosijević Marina , Kiprovski Biljana , Vidović Senka , Vladić Jelena , Pezo Lato 
Published: February 2022

AbstractThe most abundant volatile compounds of sweet wormwood (Artemisia annua L.) essential oil were artemisia ketone (25.4 %) andtrans‐caryophyllene (10.2 %), followed by 1,8‐cineole, camphor, germacrene D andβ‐selinene. The major volatile compounds in the hydrosol were camphor (25.1 %), 1,8‐cineole (20.5 %) and artemisia ketone (10.7 %), followed bytrans‐pinocarveol and yomogi alcohol. Tested essential oil was rich in oxygenated monoterpenes and sesquiterpene hydrocarbons, while the former were identified as the major class of volatile compounds in the hydrosol, due to higher water solubility. Classification of all sweet wormwood chemotypes, according to essential oil composition, in available literature (17 studies and 61 accessions) could be done according to four chemotypes: artemisia ketone+artemisia alcohol (most abundant), artemisia ketone, camphor and nonspecific chemotype. According to this classification, essential oil of sweet wormwood from this study belongs to artemisia ketone (content varied between 22.1 and 55.8 %). Bearing in mind that hydrosols are a by‐product of industrial production of essential oils, and the fact that sweet wormwood hydrosol has high contents of camphor, 1,8‐cineole and artemisia ketone, there is a great potential for the use of this aromatic plant primary processing waste product as a water replacement in cosmetic industry, beverages flavoring, for food preservation, as well as in post‐harvest pre‐storage treatments in organic agriculture.
Case report of penile cancer recurrence treated with cetuximab combined with anlotinib
Authors: Dai Shuang , Liu Yan‐Yang , Liu Tao , Zhang Yu , Luo De‐Yun 
Published: February 2022

AbstractPenile squamous cell carcinoma with pelvic lymph node metastases/recurrence has a poor prognosis. We reported a case with recurrent pSCC was administered cetuximab and anlotinib after failure of first‐line treatment and achieved an effective response. Cetuximab combined with anlotinib may be a new choice for relapsed pSCC.
Coordination and Hydroboration of Ru(II)‐Borate Complexes: Dihydridoborate vs. Bis(dihydridoborate)
Authors: Pathak Kriti , Gayen Sourav , Saha Suvam , Nandi Chandan , Mishra Shivankan , Ghosh Sundargopal 
Published: February 2022

AbstractTreatment of [Cp*RuCl2]2, 1, [(COD)IrCl]2, 2 or [(p‐cymene)RuCl2]2, 3 (Cp*=η5‐C5Me5, COD= 1,5‐cyclooctadiene and p‐cymene=η6‐iPrC6H4Me) with heterocyclic borate ligands [Na[(H3B)L], L1 and L2 (L1: L=amt, L2: L=mp; amt=2‐amino‐5‐mercapto‐1,3,4‐thiadiazole, mp=2‐mercaptopyridine) led to the formation of borate complexes having uncommon coordination. For example, complexes 1 and 2 on reaction with L1 and L2 afforded dihydridoborate species [LAM(μ‐H)2BHL] 4–6 (4: LA=Cp*, M=Ru, L=amt; 5: LA=Cp*, M=Ru, L=mp; 6: LA=COD, M=Ir, L=mp). On the other hand, treatment of 3 with L2 yielded cis‐ and trans‐bis(dihydridoborate) species, [Ru{(μ‐H)2BH(mp)}2], cis‐7 and trans‐7. The isolation and structural characterization of fac‐ and mer‐[Ru{(μ‐H)2BH(mp)}{(μ‐H)BH(mp)2}], 8 from the same reaction offered an insight into the behaviour of these dihydridoborate species in solution. Fascinatingly, despite having reduced natural charges on Ru centres both at cis‐and trans‐7, they underwent hydroboration reaction with alkynes that yielded both Markovnikov and anti‐Markovnikov addition products, 10 a–d.
New Insight into Dearomatization and Decarbonylation of Antitubercular 4H‐Benzo[e][1,3]thiazinones: Stable 5H‐ and 7H‐Benzo[e][1,3]thiazines
Authors: Richter Adrian , Seidel Rüdiger W. , Graf Jürgen , Goddard Richard , Lehmann Christoph , Schlegel Tom , Khater Nour , Imming Peter 
Published: February 2022

Abstract8‐Nitro‐4H‐benzo[e][1,3]thiazinones (BTZs) are potent in vitro antimycobacterial agents. New chemical transformations, viz. dearomatization and decarbonylation, of two BTZs and their influence on the compounds’ antimycobacterial properties are described. Reactions of 8‐nitro‐2‐(piperidin‐1‐yl)‐6‐(trifluoromethyl)‐4H‐benzo[e][1,3]thiazin‐4‐one and the clinical drug candidate BTZ043 with the Grignard reagent CH3MgBr afford the corresponding dearomatized stable 4,5‐dimethyl‐5H‐ and 4,7‐dimethyl‐7H‐benzo[e][1,3]thiazines. These methine compounds are structurally characterized by X‐ray crystallography for the first time. Reduction of the BTZ carbonyl group, leading to the corresponding markedly non‐planar 4H‐benzo[e][1,3]thiazine systems, is achieved using the reducing agent (CH3)2S ⋅ BH3. Double methylation with dearomatization and decarbonylation renders the two BTZs studied inactive against Mycobacterium tuberculosis and Mycobacterium smegmatis, as proven by in vitro growth inhibition assays.
Design, Synthesis and X‐Ray Structural Studies of Potent HIV‐1 Protease Inhibitors Containing C‐4 Substituted Tricyclic Hexahydro‐Furofuran Derivatives as P2 Ligands
Authors: Ghosh Arun K. , Kovela Satish , Sharma Ashish , Shahabi Dana , Ghosh Ajay K. , Hopkins Denver R. , Yadav Monika , Johnson Megan E. , Agniswamy Johnson , Wang Yuan‐Fang , Hattori Shin‐Ichiro , Higashi‐Kuwata Nobuyo , Aoki Manabu , Amano Masayuki , Weber Irene T. , Mitsuya Hiroaki 
Published: February 2022

AbstractThe design, synthesis, X‐ray structural, and biological evaluation of a series of highly potent HIV‐1 protease inhibitors are reported herein. These inhibitors incorporate novel cyclohexane‐fused tricyclic bis‐tetrahydrofuran as P2 ligands in combination with a variety of P1 and P2′ ligands. The inhibitor with a difluoromethylphenyl P1 ligand and a cyclopropylaminobenzothiazole P2′ ligand exhibited the most potent antiviral activity. Also, it maintained potent antiviral activity against a panel of highly multidrug‐resistant HIV‐1 variants. The corresponding inhibitor with an enantiomeric ligand was significantly less potent in these antiviral assays. The new P2 ligands were synthesized in optically active form using enzymatic desymmetrization of meso‐diols as the key step. To obtain molecular insight, two high‐resolution X‐ray structures of inhibitor‐bound HIV‐1 protease were determined and structural analyses have been highlighted.
Binary Transition Metal NiFeOx and CoFeOx Cocatalysts Boost the Photodriven Water Oxidation over Fe2TiO5 Nanoparticles
Authors: Melo Mauricio A. , Centurion Higor A. , Machado Giovanna , Souza Flavio L. , Gonçalves Renato V. 
Published: February 2022

AbstractAlthough achieving a perfect match between a cocatalyst and a photocatalyst is challenging, it is a key factor to maximize the production of solar fuels. Herein, the nanostructured binary transition metal oxides NiFeOx and CoFeOx, loaded through magnetron sputtering deposition, were employed as cocatalysts for Fe2TiO5 nanoparticles, applied to the oxygen production from solar water splitting. After the coverage of Fe2TiO5 with exceptionally small CoFeOx and NiFeOx nanoparticles, the O2 evolution boosted from 7.0 (pure Fe2TiO5) to 56.0 and 63.0 μmol, respectively, under visible light irradiation. To the best of our knowledge, these performance enhancements are the highest reported for the particulate Fe2TiO5 photocatalyst, so far. The improvements result from the alleviation of charge transfer resistance at the solid/liquid interface, as the binary metal oxides aid the charge carriers separation at the heterojunctions and improve the kinetics of the water oxidation reaction.
Pharmacokinetics and Macrophage Inhibitory Cytokine‐1 Pharmacodynamics of the Murine Double Minute 2 Inhibitor, Navtemadlin (KRT‐232) in Fed and Fasted Healthy Subjects
Authors: Wong Shekman , Krejsa Cecile , Lee Dana , Harris Anna , Simard Emilie , Wang Xiaohui , Allard Martine , Podoll Terry , O'Reilly Terry , Slatter J. Greg 
Published: February 2022

AbstractThis single 60‐mg dose, 4‐period crossover study assessed the effect of food and formulation change on navtemadlin (KRT‐232) pharmacokinetics (PK) and macrophage inhibitory cytokine‐1 (MIC‐1) pharmacodynamics. Healthy subjects (N = 30) were randomized to 3 treatment sequences, A: new tablet, fasted (reference, dosed twice); B: new tablet, 30 minutes after a high‐fat meal (test 1); C: old tablet, fasted (test 2). PK/pharmacodynamic parameters were measured over 0 to 96 hours. Adverse events were mild without any discontinuations. No serious adverse events or deaths occurred. In treatment A, navtemadlin mean (coefficient of variation) maximum concentration (Cmax) was 525 (66) ng/mL, at median time to maximum concentration (tmax) of 2 hours. Mean (coefficient of variation) area under the plasma concentration–time curve from time 0 to time t (AUC0‐t) was 3392 (63.3) ng • h/mL, and arithmetic mean terminal half‐life was 18.6 hours. Acyl glucuronide metabolite (M1)/navtemadlin AUC0‐t ratio was 0.2, and urine excretion of navtemadlin was negligible. After a meal (B vs A), navtemadlin tmax was delayed by 1 hour. Geometric least squares means ratios (90%CI) for navtemadlin Cmax and AUC0‐t were 102.7% (87.4‐120.6) and 81.4% (76.2‐86.9), respectively. Old vs new tablet fasted formulations (C vs A) had geometric least squares means ratios (90%CI) of 78.4% (72.0‐85.3) for Cmax and 85.9% (80.5‐91.7) for AUC0‐t. MIC‐1 Cmax and AUC were comparable across groups; tmax was delayed relative to navtemadlin tmax by ≈8 hours. Navtemadlin AUC0‐t and MIC‐1 AUC0‐t correlated significantly. In conclusion, navtemadlin can be administered safely with or without food; the new formulation does not affect navtemadlin PK. The 60‐mg navtemadlin dose elicited a reproducible and robust MIC‐1 response that correlated well with navtemadlin exposure, indicating that murine double minute 2 target engagement leads to p53 activation.
A novel Frei‐Chen based fragile watermarking method for authentication of an image
Authors: Renklier Ayhan , Öztürk Serkan 
Published: February 2022

AbstractIn recent years, the protection of the intellectual property rights of digital media has become a considerable issue. Especially using digital image editing tools has made it very easy and fast to manipulate images. Therefore, manipulation detection of digital images has become a necessity. This article presents a novel Frei‐Chen based self‐embedding fragile watermarking technique implemented to blocks for image manipulate detection. The block key and the Frei‐Chen based block feature are calculated from the non‐overlapping image blocks of size . Exclusive‐OR operations are applied to the Frei‐Chen based block feature and the block key. After, a nine bit block authentication key is generated from the Frei‐Chen based block feature and the block key. Then the generated authentication key is embedded in the least significant bits of each block. Experimental results prove the effectiveness of the proposed method through the detection of the various attacks and obtain the excellent visual quality of watermarked images. Also, the results demonstrate that the proposed method detects all of the manipulated areas plainly.
Advances in the Catalytic Reductive Amination of Furfural to Furfural Amine: The Momentous Role of Active Metal Sites
Authors: Saini Ms. Kanika , Kumar Sahil , Li Hu , Babu Srinivasarao Arulananda , Saravanamurugan Shunmugavel 
Published: February 2022

AbstractOne‐pot synthesis of sustainable primary amines by catalytic reductive amination of bio‐based carbonyl compounds with NH3 and H2 is emerging as a promising and robust approach. The primary amines, especially furfuryl amine (FUA) derived from furfural (FUR), with a wide range of applications from pharmaceuticals to agrochemicals, have attracted much attention due to their versatility. This Review is majorly comprised of two segments on the reductive amination of FUR to FUA, one with precious (Ru, Pd, Rh) and the other with non‐precious (Co, Ni) metals on different supports and in various solvent systems in the presence of NH3 and H2. The active metal sites generated on multiple supports are accentuated with experimental evidence based on CO‐diffuse reflectance infrared Fourier‐transform spectroscopy, H2 temperature‐programmed reduction, X‐ray photoelectron spectroscopy, and calorimetry. Moreover, this Review comprehensively describes the role of acidic and basic support for the metal on the yield of FUA. Overall, this Review provides an insight into how to design and develop an efficiently robust catalyst for the selective reductive amination of a broad spectrum of carbonyl compounds to corresponding amines.