bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness analysis of colonoscopy and fecal immunochemical testing for colorectal cancer screening in China
Authors: Ren Yinan , Zhao Mingye , Zhou Dachuang , Xing Qian , Gong Fangfang , Tang Wenxi 
Published: August 2022

ObjectiveThis study aimed to evaluate the cost-effectiveness of the colorectal cancer screening in China, and that when the screening was implemented in a specific region.MethodsA 13-state Markov model was established to compare four screening protocols, including annual fecal immunochemical testing (FIT1), biennial fecal immunochemical testing (FIT2), electronic colonoscopy every 10 years (e-CSPY10), and electronic colonoscopy every 5 years (e-CSPY5), with no screening from the perspective of Chinese healthcare system. The model simulated the health states of a cohort of 100,000 average-risk individuals aging from 50 to 75. Additionally, scenarios including the implementation in a specific region, starting from 40, and incompletely successful treatment of cancer were also analyzed.ResultsAnnual and biennial FIT could save 8.13USD (US Dollar) and 44.96USD per person, and increase 0.0705QALYs (Quality-Adjusted Life Years) and 0.2341 QALYs compared with no screening, respectively. Annual FIT could decrease costs by 36.81USD per person and increase 0.1637 QALYs in comparison to biennial FIT. The results showed that both annual and biennial FIT for screening were dominant over no screening, and annual FIT was dominant over biennial FIT. The ICER (Incremental Cost-Effectiveness Ratio) for e-CSPY10 were 1183.51USD/QALY and 536.66USD/QALY compared with FIT1 and FIT2. The ICER for e-CSPY5 were 1158.16USD/QALY and 770.85USD/QALY compared with FIT1 and FIT2. And the ICER for e-CSPY5 relative to e-CSPY10 was 358.71USD/QALY. All the ICER values were lower than the economic threshold of 2021 Chinese GDP (Gross Domestic Product) per capita in 2021(12554.42USD).ConclusionsIt is worthwhile to popularize CRC screening in mainland China, as FIT always saving costs and colonoscopy is cost-effective. Regions with high income can take electronic colonoscopy every 10 years, or even every 5 years into consideration when determining the specific strategies.
Current knowledge and “myths” about celiac disease among physicians in the Republic of Kazakhstan: A countrywide cross-sectional study
Authors: Kozhakhmetova Aizhan , Aidossov Serzhan , Kapassova Aissulu , Borsoldayeva Karlygash 
Published: August 2022

BackgroundCeliac disease (CD) is a common genetically predisposed autoimmune condition affecting the gut and other organs. Disease awareness is one of the key components of early case identification. This study aimed to assess awareness about CD among primary care physicians, who are the front-liners in suspecting the diagnosis, and other medical specialists.Methods and findingsThe questionnaire for this survey-based study was created based on the latest international guidelines on CD and included a consent form, 5 general questions (age, gender, etc.), and 10 specific questions concerning CD. Overall, 232 respondents from 13 country provinces (out of 14) and two republican cities were recruited for this study. Of them, 110 (47.4%) were primary care physicians and 122 (52.6%) other medical specialists, including 10 (4.3%) gastroenterologists. A scoring system was used to classify the level of awareness of participants into 3 categories, namely, poor, fair, and good. Analysis of responses revealed poor awareness in 59.4% of physicians, associated with work in republican/province/district/rural/village hospitals (p = 0.004), male gender (p = 0.006), and age of 40–50 years (p = 0.02). The most common “myths” about CD were the following: “symptoms are always obvious in children” or “in adults” (92.5 or 88.4% of respondents, respectively); “genetic mutation HLA DQ2/DQ8 causes the development of CD in all carriers of the mutation” (51.3%); “CD is a disease of children only” (12.5%); and “is triggered by dairy products” (8.6%). Genotyping of HLA DQ genes has been recommended in case of CD suspicion by every third respondent and was advocated as a “golden standard” confirmatory test by every fifth respondent. A quarter of respondents revealed their incorrect treatment strategies: gluten-free diet for 1 month, dairy-free diet, Helicobacter pylori eradication therapy, or responded that did not know how to treat. Overall, 93.5% of respondents expressed intention to learn more about CD, while the rest 6.5% thought that they knew enough, although their knowledge was poor.ConclusionThis study revealed a poor level of awareness among physicians in Kazakhstan and identified common misconceptions about CD, which potentially could lead to incorrect application of diagnostic tests, delay in diagnosis, and inefficient treatment. Development and implementation of educational programs as well as promotion of self-learning would increase awareness and unravel misconceptions.
Towards coupling full-disk and active region-based flare prediction for operational space weather forecasting
Authors: Pandey Chetraj , Ji Anli , Angryk Rafal A. , Georgoulis Manolis K. , Aydin Berkay 
Published: August 2022

Solar flare prediction is a central problem in space weather forecasting and has captivated the attention of a wide spectrum of researchers due to recent advances in both remote sensing as well as machine learning and deep learning approaches. The experimental findings based on both machine and deep learning models reveal significant performance improvements for task specific datasets. Along with building models, the practice of deploying such models to production environments under operational settings is a more complex and often time-consuming process which is often not addressed directly in research settings. We present a set of new heuristic approaches to train and deploy an operational solar flare prediction system for ≥M1.0-class flares with two prediction modes: full-disk and active region-based. In full-disk mode, predictions are performed on full-disk line-of-sight magnetograms using deep learning models whereas in active region-based models, predictions are issued for each active region individually using multivariate time series data instances. The outputs from individual active region forecasts and full-disk predictors are combined to a final full-disk prediction result with a meta-model. We utilized an equal weighted average ensemble of two base learners’ flare probabilities as our baseline meta learner and improved the capabilities of our two base learners by training a logistic regression model. The major findings of this study are: 1) We successfully coupled two heterogeneous flare prediction models trained with different datasets and model architecture to predict a full-disk flare probability for next 24 h, 2) Our proposed ensembling model, i.e., logistic regression, improves on the predictive performance of two base learners and the baseline meta learner measured in terms of two widely used metrics True Skill Statistic (TSS) and Heidke Skill Score (HSS), and 3) Our result analysis suggests that the logistic regression-based ensemble (Meta-FP) improves on the full-disk model (base learner) by ∼9% in terms TSS and ∼10% in terms of HSS. Similarly, it improves on the AR-based model (base learner) by ∼17% and ∼20% in terms of TSS and HSS respectively. Finally, when compared to the baseline meta model, it improves on TSS by ∼10% and HSS by ∼15%.
Analysis of the drainage effect of different incisions for high complex anal fistula based on FLUENT hydrodynamic simulation
Authors: Zhang Jiamin , Li Xiang , Ma Jiaze , Chen Peng , Li Wanli , Hu Junjie , Li Xiaoliu , Chen Yile , Ding Kang 
Published: August 2022

PurposeThe biomechanical characteristics of the trauma size and postoperative drainage of different incisions for high complex anal fistula surgery were compared by numerical simulation analysis to provide a theoretical basis for the clinical selection of minimally invasive incisions for surgery.MethodsUsing FLUENT finite element software, a typical incision finite element model was established to obtain incision areas, and the total mass outlet flow within 200 s was calculated to evaluate the drainage effect of each incision.ResultsThe incisions with the largest to smallest areas were the curved, spindle, and curved plus extended groove incision, indicating that the curved plus extended groove incision caused the least damage to the perianal skin muscles. Conversely, the incisions with the largest to smallest total outlet flow were as follows: curved plus extended groove, spindle, curved, and straight incision, suggesting that the curved plus extended groove model had the best diversion effect, and the curved incision had better diversion effect than that of the straight incision.ConclusionThe curved plus extended groove surgical incision had the smallest incision area, minimized damage to the perianal skin and muscle tissue, conformed to the concept of minimally invasive surgery, ensured adequate drainage of exudate, maintained the normal growth of granulation tissue on the wound surface, preserved the original form of the anus, and thus better protected the function of the anus. This improved the quality of life of patients requiring high complex anal fistulas.
Distal end of Double-J ureteral stent position on ureteral stent-related symptoms: A systematic review and meta-analysis
Authors: Bao Xingjun , Sun Fengze , Yao Huibao , Wang Di , Liu Hongquan , Tang Gonglin , Wang Xiaofeng , Zhou Zhongbao , Wu Jitao , Cui Yuanshan 
Published: August 2022

BackgroundMost patients suffer from ureteral stent-related symptoms (USRS) caused by indwelling ureteral stents. Nevertheless, various medications to alleviate discomfort as well as novel stents are continually being developed, and in recent years, some researchers have believed that proper intravesical stent placement can relieve USRS.ObjectiveTo determine appropriate intravesical ureteral stent position may alleviate USRS.MethodsUp to May 1, 2022, the PubMed, Embase, Scopus and Web of Science databases were thoroughly searched, and two independent reviewers included relevant studies that met the PICO (Patient, Intervention, Comparison, Outcome) criteria. Studies methodological quality were assessed by ROB2 and ROBINS-I. Ureteral stent symptom questionnaire (USSQ), international prostate symptom score (IPSS) and quality of life (QoL) was used to quantify the USRS. According to intravesical ureteral stent position, Group A was defined as the contralateral group, that is distal end of ureteral stent crossed the bladder midline, whereas Group B was classified as ipsilateral group, meaning stent end did not cross the midline.ResultsSix studies incorporating a total of 590 patients were eligible. In terms of USSQ score, the meta-analysis showed that contralateral group was associated with a significant increase in USSQ total (MD, 17.55; 95% CI, 12.04 to 23.07; P &lt; 0.001), urinary symptoms (MD, 2.74; 95% CI, 0.48 to 5.01; P = 0.02), general health (MD, 4.04; 95% CI, 2.66 to 5.42; P &lt; 0.001), work performance (MD, 1.36; 95% CI, 0.75 to 1.98; P &lt; 0.001) and additional problems (MD, 0.89; 95% CI, 0.47 to 1.32; P &lt; 0.001) scores while not associated with a significant increase in body pain (MD, 3.13; 95% CI, −0.19 to 6.44; P = 0.06) and sexual matters (MD, 1.01; 95% CI, −0.03 to 2.06; P = 0.06). As for IPSS, although no significant differences in IPSS total (MD, 2.65; 95% CI, −0.24 to 5.54; P = 0.07) or voiding symptoms (MD, −0.84; 95% CI, −3.16 to 1.48; P = 0.48) scores were found, ipsilateral group was associated with a significant decrease in storage symptoms (MD, 1.92; 95% CI, 0.91 to 2.93; P = 0.0002). Furthermore, ipsilateral group was linked to a significant decrease in QoL score (MD, 1.00; 95% CI, 0.18 to 1.82; P = 0.02).ConclusionThis meta-analysis proven that correct intravesical stent position was critical, and patients with stents crossing the midline experienced more severe USRS than those who did not. Further high-quality randomized controlled trials are needed to corroborate our findings.
Pan-immune-inflammation value is associated with the clinical stage of colorectal cancer
Authors: Zhao HanZheng , Chen Xingyu , Zhang WenHui , Cheng Die , Lu Yanjie , Wang Cheng , Li JunHu , You LiuPing , Yu JiaYong , Guo WenLong , Li YuHong , Huang YueNan 
Published: August 2022

ObjectiveWe investigated the clinical significance of preoperative pan-immune-inflammation value (PIV) in patients with colorectal cancer (CRC).MethodsIn this retrospective study, 366 cases who underwent surgery for CRC were enrolled. Their clinical data were collected. PIV was calculated with the formula PIV = [neutrophil count (109/L)× platelet count (109/L) × monocyte count (109/L) /lymphocyte count (109/L). Patients were divided into high PIV (&gt; median PIV) and low PIV (&lt; median PIV) groups. The relationship between PIV and clinicopathological features of CRC was investigated. Receiver operating characteristic (ROC) curve was plotted to indicate the value of immune-inflammatory biomarkers (IIBs) in predicting the TNM stage of CRC, and the area under the curve (AUC) was calculated to evaluate the actual clinical value of IIBs. AUC &gt; 0.5 and closer to 1 indicated the better predictive efficacy. The influencing factors of PIV in CRC were analyzed.ResultsWe found that PIV was positively correlated with tumor size (r = 0.300, p &lt; 0.05), carcinoembryonic antigen (CEA) (r = 0.214, p &lt; 0.05) and carbohydrate antigen 125 (CA-125) (r = 0.249, p &lt; 0.05), but negatively correlated with albumin (Alb) (r = −0.242, p &lt; 0.05). PIV was significantly different in patients with different tumor locations (left or right), surgical methods (laparotomy versus laparoscopic surgery) (p &lt; 0.05), and patients with different pathological T stages, N-stage and TNM stages (p &lt; 0.05). ROC curve analysis of IIBs showed the AUC of PIV was greater than other markers when combined with CEA or carbohydrate antigen 19–9 (CA19–9). Multivariate regression analysis identified T stage, CEA, Alb, and tumor size as the independent influential factors of PIV in CRC.ConclusionPIV is associated with the tumor stage in patients with CRC, which may be useful in preoperative assessment of CRC.
Algebraic integers of certain cubic extensions
Authors: Andrade Antonio Aparecido de , Facini Linara Stéfani , Esteves Livea Cichito 
Published: August 2022

There is an extensive literature of cyclic number fields and cyclic fields of type, where and is a square free integer, for example [3], [4] and [5]. In this work, we present new results of the structure of the ring of algebraic integers of cubic number fields, that is, we explicitly give an integral basis of a cubic field in the form , where is a cube free integer, and its discriminant.
Relato de caso: esplenectomia em cadela com Sarcoma de células Fusiformes em baço
Authors: Silva Tatiane Fatima Eing Mello e 
Published: August 2022

Os tumores esplênicos podem acometer vários mamíferos, independentemente da raça ou sexo, como cães e gatos, tendo maior incidência nos idosos. Na rotina clínica são comuns alterações identificadas em pequenos animais com tumores em baço, sendo a esplenectomia o tratamento cirúrgico inicial após o diagnosticado. Para auxiliar no diagnóstico exames de imagem são mais eficazes, como a ultrassonografia que é mais utilizada porque identifica melhor as medidas, formas e metástases dos tumores abdominais. O diagnóstico prévio é reservado pois os sinais clínicos são inespecíficos e geralmente ocorrem tardiamente. Alguns sinais clínicos podem ser: anorexia; aumento de volume abdominal; letargia; depressão; êmese; choque hipovolêmico ou hemorragias na cavidade abdominal decorrentes de rupturas ou necrose do baço e órgãos adjacentes. Nesse relato será descrito o caso ocorrido com uma cadela de 10 de idade com alteração esplênica. No exame físico foi identificado massa tumoral em região topográfica de baço e identificado liquido intersticial, confirmado por exame ultrassonográfico. Devido ao quadro clínico da paciente foi realizada cirurgia de emergência, logo após o diagnóstico, devido ao grande risco de óbito. O objetivo deste relato de caso foi demonstrar o diagnóstico e o tratamento para resolução de tumores malignos acometendo o baço. Outrossim, ressaltar a importância do diagnóstico precoce, sobretudo em animais na fase adula e senil, a partir da realização de exames clínicos rotineiros: como hemograma; bioquímicos; exames de imagem, em razão do aparecimento tardio dos sinais clínicos.
Ozonioterapia no tratamento de feridas em cães diabéticos
Authors: Da Silva Anderson Carlos , Ramos Maria de Lourdes Santos , Jotta Paloma Carolina Leão de Oliveira , Da Costa Ana Carolina Messias de Souza Ferreira , Franco Eryvelton de Souza 
Published: August 2022

A medicina veterinária vem evoluindo cada dia mais acerca de novos tratamentos e técnicas, que auxiliam o médico veterinário em sua rotina e ajudam os seus pacientes a receberem o que há de mais novo em tratamento para suas patologias e enfermidades. Dentre esses tratamentos e evoluções, destaca-se a ozonioterapia, técnica que faz uso da combinação ozônio e oxigênio, que tem se tornado uma grande aliada no tratamento de diversas doenças, por apresentar resultados bastante satisfatórios. Em meio a essas doenças, destacam-se a Diabetes Mellitus tipos I e II, doença endócrina de origem autoimune ou adquirida, que tem por característica o aumento de açúcar circulante na corrente sanguínea conhecida como hiperglicemia. O paciente diabético por sua vez, enfrenta dificuldade na cicatrização de feridas devido a sua condição fisiológica, e a ozonioterapia vem auxiliando esses pacientes na evolução de seu tratamento. Por isso objetivou-se compreender como a ozonioterapia pode contribuir para a cicatrização das feridas de cães diabéticos. Utilizou-se uma metodologia em foram selecionados trabalhos com temas relacionados ao assunto. Os artigos foram publicados no intervalo de 2017 a 2022 e serviram para embasar o desenvolvimento do trabalho. Para tanto se usou buscadores como Google acadêmico e Scielo. Percebeu-se que a ozonioterapia pode trazer bons resultados no processo de cicatrização da ferida em cães diabéticos, mas deve-se ser usada como tratamento complementar.
The Effectiveness Of Lavender Aromatherapy And Deep Relaxation Techniques To Reduce Labor Anxiety To Mothers In Membership During The Latent Phase I At Pmb K Bogor City In 2022
Authors: Emalia Eliska , Syamsiah Siti , Dahlan Febry Mutiariami 
Published: August 2022

Angka kejadian kecemasan pada ibu hamil dalam menghadapi persalinan di Indonesia pada tahun 2019 sebesar 28,7%. Sedangkan pada tahun 2020 mengalami peningkatan sebesar 48,7%. Tujuan penelitian ini untuk mengetahui efektivitas aromaterapi lavender dan Teknik relaksasi nafas dalam untuk mengurangi kecemasan menghadapi persalinan pada ibu bersalin kala I fase laten di PMB K Kota Bogor tahun 2022. Desain penelitian yang digunakan dalam penelitian ini yaitu pretest-posttest With Control Group Design. Sampel penelitian ini adalah sebagian ibu bersalin yang berkunjung ke PMB K pada periode April sampai Juli tahun 2022 yaitu sebanyak 30 orang. Instrumen penelitian dalam penelitian ini menggunakan SAP penggunaan diffuser dan teknik rileksasi nafas dalam, serta kuesioner HARS (Hamilton Anxiety Rating Scale). Hasil uji statistik Independent T Test menunjukkan nilai p value sebesar 0,001 ≤ 0,05, berarti adanya pengaruh sebelum dan sesudah diberikan aromaterapi lavender dan teknik relaksasi nafas dalam untuk mengurangi kecemasan menghadapi persalinan pada kelompok intervensi kala I fase laten di PMB K Kota Bogor tahun 2022. Kesimpulan adanya pengaruh sebelum dan sesudah diberikan aromaterapi lavender dan teknik relaksasi nafas dalam untuk mengurangi kecemasan menghadapi persalinan pada kelompok intervensi kala I fase laten di PMB K Kota Bogor tahun 2022. Saran ibu bersalin yang mengalami kecemasan dalam menghadapi persalinan kala I fase laten diharapkan dapat menggunakan aromaterapi lavender dan tehnik nafas dalam sebagai terapi alternatif untuk mengurangi kecemasan.
Kata Kunci: Aromaterapi Lavender, Kecemasan, Teknik Relaksasi Nafas Dalam
Pelaksanaan Pengembangan Motorik Kasar Anak Usia Dini di Taman Kanak-kanak Harapan Pangian Lintau Buo
Authors: Safitri Safia , Izzati Izzati 
Published: August 2022

Penelitian ini bertujuan guna mendeskripsikan tentang pelaksanaan pengembangan motorik kasar anak usia dini. Jenis penelitian yang digunakan adalah ialah penelitian deskriptif dengan pendekatan kualiatatif. Tenik pengumpulan data penelitian melalui observasi dilakukan sebelum pelaksanaan wawancara serta dokumentasi dalam penelitian. Selanjutnya data dikumpulkan untuk direduksi, disajikan, hingga dilakukan verifikasi terhadap data yang didapatkan. Sedangkan teknik keabsahan data menggunakan triangulasi. Penelitian ini memuat perencanaan kegiatan pengembangan motorik kasar anak usia dini berpedoman pada tema, sub tema dan indikator yang dirancang sebelum ajaran baru. Pelaksanaan kegiatan di sentra olah tubuh kegiatanya mencari gambar benda-benda langit, mengelompokkan bendera sambil berlari dan melompat, berjalan di atas papan titian serta perlombaan bakiak. Evaluasi kegiatan pengembangan motorik kasar anak dilakukan melalui penilaian proses observasi, daftar ceklis, dan catatan anekdot.Kata Kunci: Pengembangan Motorik Kasar, Anak Usia DiniAbstractThis study aims to describe abaout implementation of gross motor development in early childhood. The type of research used is descriptive research with a qualitative approach. Research data colecction techniques through observation, interviews, and dicumentation. Data analysis was performed by collecting data, dara reduction, data presentation and verification. While the data validity technique used triangulation. This activities for early childhood based on the themes, sub themes anf indicators that were designed before the new teaching. The implementation of activities at the sports center includes looking for pictures of celestial objects, gruping flags while running and jumping, walking on footpaths and competing clongs. Evaluation of children’s gross motor development activities is carried out through assessment of the observation process, cheklists, and anecdotal notes.Keywords: Gross Motor Development, Early Childhood
Cavity-enhanced two-photon source emitting narrow linewidth telecommunication wavelength photons for improved quantum memory-coupling efficiency enabling long-distance quantum communications
Authors: Onozawa Ryo , Yoshida Daisuke , Niizeki Kazuya , Horikiri Tomoyuki 
Published: August 2022

Abstract
In long-distance quantum communication using quantum repeaters with quantum memories, entangled photons at telecommunication wavelengths that can be coupled to quantum memory with high efficiency are required. Typically, entangled photons are generated via spontaneous parametric down conversion (SPDC). However, the phase-matching bandwidth of SPDC is more than 100 GHz, which is much broader than the bandwidth of a Pr3+:Y2SiO5 quantum memory (with overall bandwidth of ∼10 GHz while the bandwidth of each frequency channel is ∼10 MHz) suitable for frequency-multiplexed quantum repeaters. In this study, nondegenerate SPDC (1550 nm and 995 nm) inside an optical cavity is used to obtain a narrow linewidth and cluster width of SPDC to match the Pr3+:Y2SiO5 bandwidth. We also developed a cavity control mechanism that can fulfill the doubly resonant condition. The developed two-photon source can maximize the coupling efficiency with Pr3+:Y2SiO5 by introducing wavelength conversion and is promising for use in a quantum repeater.