bluuebunny/crossref_metadata_2025_split huggingface dataset:
San Quirce (Palencia, Spain): new chronologies for the Lower to Middle Palaeolithic transition of south‐west Europe
Authors: Terradillos‐Bernal Marcos , Demuro Martina , Arnold Lee J. , Jordá‐Pardo Jesús F. , Clemente‐Conte Ignacio , Benito‐Calvo Alfonso , Díez Fernández‐Lomana J. Carlos 
Published: July 2022

AbstractSan Quirce is an open‐air archaeological site situated on a fluvial terrace in the Duero basin (Palencia, northern Iberia). This paper presents new and consistent chronologies obtained for the sedimentary sequence using post‐infrared infrared stimulated luminescence (pIR‐IR) dating of K‐feldspars and single‐grain thermally transferred optically stimulated luminescence (TT‐OSL) dating of quartz. The new dating results indicate that the sequence is older than ~200 000 years and place San Quirce Level III within marine isotope stages (MIS) 8 and 7, between 274 ± 13 ka and 238 ± 13 ka. The main lithic assemblage at San Quirce comes from Level III. The predominant tool types found in this level are hammerstones, manuports and flakes, with a small proportion of cores and a significant presence of denticulates. Adaptation to local environmental conditions resulted in distinctive cultural habits, which were embedded in the cultural tradition of hominins occupying the site during the final third of the Middle Pleistocene. San Quirce preserves a simple cultural tradition that was employed by local hominins to engage in a diverse array of activities, and highlights the cultural diversity that appears to have been a characteristic feature of the Lower to Middle Palaeolithic transition 300–200 ka.
Quartz luminescence sensitivity variation in the Chinese loess deposits: the potential role of wildfires
Authors: Zhang Junjie , Li Sheng‐Hua , Sun Jimin , Lü Tongyan , Zhou Xinying , Hao Qingzhen 
Published: July 2022

AbstractThe sensitivity of optically stimulated luminescence (OSL) of quartz grains has been applied to trace the provenances of sediments in various environments. Here, we studied the OSL sensitivity of quartz grains in four sections (Jingyuan, Huanxian, Xifeng and Luochuan) along a west–east transect on the Chinese Loess Plateau (CLP). The quartz OSL sensitivity in the palaeosol units is higher overall than that in the loess units, and it shows an increasing trend from the west CLP to the east CLP. In palaeosol units, it increases by a factor of ~20 along the west–east transect; while in loess units it increases by a smaller degree of 3–5. The change of provenances and the change of distances between the provenances and the loess sections cannot fully account for the large degree of sensitivity variation between the loess and palaeosol units in the central and eastern CLP. We propose that wildfires may have played an important role in enhancing the quartz OSL sensitivity in the palaeosol units in the central and eastern CLP. Quartz OSL sensitivity has the potential to be used as a proxy for palaeowildfires.
Cover Image
Authors: Cheng Ke , Zhang Jianghua , Yang Shasha , Yin Fawen , Li Zixuan , Wang Ting , Zhou Dayong 
Published: July 2022

The cover image is based on the Research Article Acidolysis of phospholipids with medium‐chain fatty acids over M‐SBA‐15 (M = Zn, Al) silicas as efficient solid catalysts by Fawen Yin et al., https://doi.org/10.1002/jsfa.11832.image
Overall survival and prognostic factors in Stage I lung adenocarcinoma treated with curative intent: A real‐life 19‐year cohort study
Authors: Abrão Fernando Conrado , de Abreu Igor Renato Louro Bruno , Silva Vinícius Guimarães , Rosamilia Gabriel de Andrade , Peres Stela Verzinhasse , Hanriot Rodrigo de Morais , Younes Riad Naim 
Published: July 2022

AbstractObjectivesImportant differences in Stage I non–small‐cell lung cancer (NSCLC) are related to the delay in the diagnosis to the treatment, hospitals' specialised status, comorbidities, tumour stage and histological type.MethodsA 19‐year retrospective cohort study was conducted, including 681 patients with NSCLC in clinical‐stage IA–IB. The variables analysed were gender, age, schooling, type of health care provider, type of treatment, period of 5‐year treatment, the time between first attendance to diagnosis and the time between diagnosis and treatment, and hospital's specialised status.ResultsPatients who underwent radiotherapy alone had three times more risk of death than those who underwent surgery alone (adjusted hazard ratio [adjHR] = 3.44; 95% confidence interval [CI]: 2.45–4.82; p <0.001). The independent risk of death factors was being treated in nonhigh complexity centres in oncology hospitals and having started the treatment more than 2 months after diagnosis (adjHR = 1.80; 95% CI: 1.26–2.56; p <0.001) and (adjHR = 2.00; 95% CI: 1.33–3.00; p <0.001), respectively. In addition, the patients diagnosed between 2011 and 2015 had a 40% lower risk of death when compared to those diagnosed between 2000 and 2005 (95% CI: 0.38–0.94; p = 0.027).ConclusionThe overall survival in curative intent Stage‐I lung cancer patients' treatment was associated with the 5‐year diagnosis group, the delayed time between diagnosis and treatment and the hospital qualification.
Proximal Scar Progression in Idiopathic Subglottic Stenosis After Wedge Excision: Does it Happen?
Authors: Xie Katherine Z. , Bowen Andrew Jay , Richards Bradley A. , Aden Aisha , Wiedermann Joshua , Rutt Amy L. , Vassallo Robert , Edell Eric S. , Bayan Semirra L. , Kasperbauer Jan L. , Ekbom Dale C. 
Published: July 2022

ObjectiveTo compare the incidence of glottic stenosis in idiopathic subglottic stenosis (iSGS) patients with no prior surgical intervention to those with a history of endoscopic dilation and characterize the incidence of glottic involvement, changes in scar length, and progression of scar toward glottis following laser wedge excision (LWE).MethodsA retrospective review of iSGS patients who underwent LWE between 2002 and 2021 was performed. Patients without prior airway surgery were labeled LWE primary (LWEP) and operative findings for LWEP patients were reviewed for glottic involvement, scar length (DL), and distance from the glottis to superior‐most aspect of scar (DGS). Rates (in mm/procedure) of DΔL, reflecting an increase in length, and D−ΔGS, reflecting proximal migration, were calculated by dividing DΔL and D−ΔGS by the number of LWE procedures.Results213 iSGS patients underwent LWE, with 132 being LWEP patients. LWEP had a lower incidence of baseline glottic involvement (n = 6, 4.5%) than LWE secondary (LWES; n = 6, 7.5%). Four new cases of glottic involvement were noted in LWEP patients following LWE, with only one being clinically significant resulting in permanently decreased vocal fold mobility. With each procedure, scar length increased by 1.0 mm and DGS decreased by 0.7 mm, reflecting a migration or decrease in DGS of 9.5% with each procedure with respect to initial DGS. Overall rates of glottic stenosis following operations were similar between LWEP and LWES cohorts, 7.6% and 7.5% respectively.ConclusionThere appears to be a low risk of glottic involvement resulting from the LWE procedure in iSGS patients.Level of Evidence4 Laryngoscope, 133:875–882, 2023
Electrospun Antibacterial Composites for Cartilage Tissue Engineering
Authors: Samie Muhammad , Khan Ather Farooq , Hardy John George , Yameen Muhammad Arfat 
Published: July 2022

AbstractImplantation of biomaterials capable of the controlled release of antibacterials during articular cartilage repair may prevent postoperative infections. Herein, biomaterials are prepared with biomimetic architectures (nonwoven mats of fibers) via electrospinning that are composed of poly(ɛ‐caprolactone), poly(lactic acid), and Bombyx mori silk fibroin (with varying ratios) and, optionally, an antibiotic drug (cefixime trihydrate). The composition, morphology, and mechanical properties of the nanofibrous mats are characterized using scanning electron microscope, Fourier transform infrared spectroscopy, and tensile testing. The nonwoven mats have nanoscale fibers (typical diameters of 324–725 nm) and are capable of controlling the release profiles of the drug, with antibacterial activity against Gram +ve and Gram −ve bacteria (two common strains of human pathogenic bacteria, Staphylococcus aureus and Escherichia coli) under in vitro static conditions. The drug loaded nanofiber mats display cytocompatibility comparable to pure poly(ɛ‐caprolactone) nanofibers when cultured with National Institutes of Health (NIH) NIH‐3T3 fibroblast cell line and have long‐term potential for clinical applications in the field of pharmaceutical sciences.
MOF‐Based Hierarchically Porous Monoliths Prepared via High Internal Phase Emulsion Template: Morphology, Thermal Stability, Mechanical Property, and MOF Accessibility
Authors: Wang Jierui , Qin Jianliang , Zhu He , Li Bo‐Geng , Zhu Shiping 
Published: July 2022

AbstractIn this work, hierarchically macro/microporous monolithic MOF composite materials are fabricated through the HIPE template. The effects of MOF loading on the pore structure, thermal stability, mechanical property, and MOF accessibility are systematically investigated. As the MOF loading increased, the average pore size and mechanical property decreased while the thermal stability increased. Meanwhile, when the MOF loading is low, the monolith exhibited a low BET surface area, suggesting a low MOF accessibility due to the clogging of MOF pores by polymer and the embedment of MOF particles inside the polymer matrix, while at high MOF loadings, the accessibility can be increased to ≈80% owing to the formation of percolation network of MOF particles inside the polymer matrix. Finally, the obtained monolith exhibited good catalytic performance and can be easily regenerated and reused. This work provides some fundamental understandings of the effect of MOF loading on the properties of HIPE‐based porous monoliths and can facilitate the further development of MOFs and their composites.
Conformal microstrip array antenna with the omnidirectional pattern for 5G applications
Authors: Shaw Minakshmi , Choukiker Yogesh K. 
Published: July 2022

AbstractThis letter presents an omnidirectional conformal array microstrip patch antenna at 3.5 GHz band. The array of 1  2 elements are used as a radiating element and placed on the planar face of a regular six‐faced hexagonal structure connected with six faced feeding network. The feeding network consists of one three‐way power divider and two two‐way power dividers. These power dividers are serially connected to each other and form a six‐faced regular structure with 12 output ports. The response of the conformal antenna is verified experimentally. A measured reflection coefficient is well below  dB and isolation between the output ports are −20 dB. The proposed omnidirectional conformal antenna is low‐cost, easy to fabricate, and suitable for an omnidirectional radiation pattern for 5G applications.
Mixed impacts of protected areas and a cash crop boom on human well‐being in North‐Eastern Madagascar
Authors: Llopis Jorge C. , Diebold Clara L. , Schneider Flurina , Harimalala Paul C. , Andriamihaja O. Ravaka , Messerli Peter , Zaehringer Julie G. 
Published: July 2022

Abstract

Tropical forest frontier areas support the well‐being of local populations in myriad ways. Not only do they provide the material basis for people's livelihoods, they also sustain socio‐cultural foundations through relational values. They host some of the most biodiverse ecosystems and largest carbon stocks on the planet, and are thus a focus of global conservation efforts. They are also a prime location for the production of many global agricultural commodities. These dynamics—often intertwined—may trap local populations between powerful interests, with the potential to affect their well‐being.

We conducted 100 structured interviews in four biodiversity‐rich landscapes of north‐eastern Madagascar to investigate how multi‐dimensional human well‐being is affected by the recent establishment of protected areas and surge in cash crop prices. We asked households about their satisfaction—and changes in satisfaction—with locally relevant well‐being components, mapping their answers through Nussbaum's Central Capabilities approach. We also investigated the cultural significance of key natural resources beyond the material benefits they provide. All issues were explored along four variables: site, main source of rice, gender and household land use portfolio.

Our findings are as follows: first, human capabilities are interconnected and mutually interdependent, with relational values linking many of them. Second, subjective accounts of well‐being are influenced by cognitive biases, such as treadmill effects, adaptive preferences and recency bias. Third, while households perceived a positive influence of protected areas, those most reliant on forest land and products held a more negative view of conservation interventions. And fourth, while households more engaged in commercial agriculture may be benefitting economically from the recent increase in cash crop prices, these very dynamics might be leading to trade‐offs between capabilities. This is most notably so for the Bodily Health capability (e.g. greater spending on housing) and Affiliation and Bodily Integrity (i.e. worsening social relations and security).

These insights highlight the importance of addressing the multiple dimensions of well‐being when assessing the impacts of conservation and economic dynamics in forest frontier populations. Particular attention should be paid to the relational values ascribed to the natural resources the communities rely on.

Read the free Plain Language Summary for this article on the Journal blog.
The 28th Annual Prostate Cancer Foundation Scientific Retreat report
Authors: Miyahira Andrea K. , Soule Howard R. 
Published: July 2022

AbstractBackgroundThe 28th Annual Prostate Cancer Foundation (PCF) Scientific Retreat was held virtually over 4 days, on October 28−29 and November 4−5, 2021.MethodsThe Annual PCF Scientific Retreat is a leading global scientific conference that focuses on first‐in‐field, unpublished, and high‐impact basic, translational, and clinical prostate cancer research, as well as research from other fields with high probability for impacting prostate cancer research and patient care.ResultsPrimary areas of research discussed at the 2021 PCF Retreat included: (i) prostate cancer disparities; (ii) prostate cancer survivorship; (iii) next‐generation precision medicine; (iv) PSMA theranostics; (v) prostate cancer lineage plasticity; (vi) tumor metabolism as a cancer driver and treatment target; (vii) prostate cancer genetics and polygenic risk scores; (viii) glucocorticoid receptor biology in castration‐resistant prostate cancer (CRPC); (ix) therapeutic degraders; (x) new approaches for immunotherapy in prostate cancer; (xi) novel technologies to overcome the suppressive tumor microenvironment; and (xii) real‐world evidence and synthetic/virtual control arms.ConclusionsThis article provides a summary of the presentations from the 2021 PCF Scientific Retreat. We hope that sharing this knowledge will help to improve the understanding of the current state of research and direct new advances in prostate cancer research and care.
Measuring green technology adoption across countries
Authors: Elgin Ceyhun , Özgür Gökçer , Cantekin Kerem 
Published: July 2022

AbstractIn this article, we construct an empirical framework to identify and measure the adoption of green technologies across countries. Using an annual dataset covering 89 countries from 1990 to 2016, we conduct a principal component analysis incorporating the different dimensions of the adoption of green technologies. The analysis allows us both to rank countries for their level of green technology adoption and also recommend policies to improve their current stance.
Thrombotischer Verschluss der extrakorporalen Zirkulation während hepatischer Chemosaturation trotz zielgerechter Antikoagulation
Authors: Kuhner M. , Tan B. , Fiedler M. O. , Biecker O. , Klein B. , Chang D. H. , Weigand M. A. , Dietrich M. 
Published: July 2022

ZusammenfassungDie perkutane hepatische Chemosaturation ist eine Behandlungsoption bei nichtresektablen primären oder sekundären Lebertumoren. Dabei wird der Bereich der Lebervenenmündung der Vena cava inferior (VCI) mittels 2 Ballons von der Zirkulation isoliert, sodass die systemische Verteilung des über die Leberarterie applizierten Chemotherapeutikums Melphalan verhindert wird. Nach Passage der Leber und venöser Drainage aus der retrohepatischen VCI durchläuft das chemosaturierte Blut 2 parallel geschaltete extrakorporale Filter. Anschließend wird das gereinigte Blut jugulär rückgeführt. Das Verfahren geht oft mit einer ausgeprägten hämodynamischen Instabilität einher, deren Ursache nicht abschließend geklärt ist. Zusätzlich stellt das Gerinnungsmanagement eine Herausforderung dar. Die Autoren berichten von einem Fall, bei dem sich trotz ausreichender „activated clotting time“ (ACT) ein Thrombus im rückführenden Schenkel der extrakorporalen Zirkulation bildete. Gezielte Problemsuche und -lösung waren parallel zur hämodynamischen Stabilisierung und interdisziplinären Zusammenarbeit notwendig, um die Intervention erfolgreich durchzuführen und der Patientin eine sichere Therapie zukommen zu lassen.
Accurate vibration-free robotic milling electric discharge machining
Authors: Almeida Sergio , Mo John , Bil Cees , Ding Songlin 
Published: July 2022

AbstractTraditional computer numeric control (CNC) machines have high accuracy but are limited by workpiece size and axes. Therefore, many researchers attempted to equip six-axis industrial robots (IRs) with milling end-effectors to explore the robot’s large and flexible working envelope. However, IRs lack stiffness and have limited force, resulting in low accuracy, poor surface roughness (SR), and low material removal rate (MRR). On the contrary, electric discharge machining (EDM) is a non-conventional process capable of shaping complex profiles in any conductive material. Since the EDM process has no physical contact between the electrode and the workpiece, it can machine diverse hard-to-cut materials accurately and free of vibration. However, to this day, EDM is found in limited conditions of CNC machines only. Thus, this research investigates a synergistic combination of IR and milling EDM. Adopting advanced CAM tools and offline programming, it examines pre-designed electrodes working analogue to conventional milling to perform the desired machining by intricate cutting paths. The results deliver a robotic machining technique able to cut hard materials using small industrial robots yet free of vibration and not pose dependent.
Identification of the initial reactive sites of micellar and non-micellar casein exposed to microbial transglutaminase
Authors: Duerasch Anja , Konieczny Maja , Henle Thomas 
Published: July 2022

AbstractTo investigate the influence of the internal micellar structure on the course of enzymatic cross-linking especially in the initial phase of the reaction, casein micelles isolated from raw milk via ultracentrifugation were incubated with microbial transglutaminase (mTG) in comparison with non-micellar sodium caseinate. Reactive lysine and glutamine residues were identified using a label-free approach, based on the identification of isopeptides within tryptic hydrolysates by targeted HRMS as well as manual monitoring of fragmentation spectra. Identified reactive sites were furthermore weighted by tracking the formation of isopeptides over an incubation time of 15, 30, 45 and 60 min, respectively. Fifteen isopeptides formed in the early stage of mTG cross-linking of caseins were identified and further specified concerning the position of lysine and glutamine residues involved in the reaction. The results revealed lysine K176 and glutamine Q175 of β-casein as the most reactive residues, which might be located in a highly flexible region of the molecule based on different possible reaction partners identified in this study. Except for the isopeptide αs1 K34–αs2 Q101 in sodium caseinate (SC), all reactive sites were detected in micellar and in non-micellar casein, indicating that the initial phase of enzymatic cross-linking is not affected by micellar aggregation of caseins.
Graphical abstract
Biomechanical evaluation of the proximal chevron osteotomy in comparison to the Lapidus arthrodesis for the correction of hallux valgus deformities
Authors: Kasparek Maximilian F. , Benca Emir , Hirtler Lena , Willegger Madeleine , Boettner Friedrich , Zandieh Shahin , Holinka Johannes , Windhager Reinhard , Schuh Reinhard 
Published: July 2022

Abstract

Purpose
The proximal chevron osteotomy and the modified Lapidus arthrodesis are both procedures utilized for deformity correction in patients with severe symptomatic hallux valgus. The aim of the current study was to compare their biomechanical stability when using locking plate fixation.

Methods
Twelve matched pairs of human anatomical lower leg specimens underwent on one side a proximal chevron osteotomy with a medial locking plate and on the other side a modified Lapidus arthrodesis with a plantar locking plate utilizing an interfragmentary compression screw. All specimens underwent bone mineral density (BMD) assessment and were tested in a servohydraulic load frame which applied a load on the centre of the metatarsal head over 1000 loading cycles with subsequently ultimate load testing. Displacement of the proximal and distal bone segment, ultimate load, and bending stiffness were analyzed.

Results
Mean displacement of both procedures showed no statistically significant difference throughout all the loading cycles (0.213 ≤ p ≤ 0.834). The mean ultimate load of the proximal chevron osteotomy was 227.9 N (± 232.4) and of the modified Lapidus arthrodesis 162.9 N (± 74.6) (p = 0.754). The proximal chevron osteotomy (38.2 N/mm (± 24.9)) had a significantly higher bending stiffness compared to the modified Lapidus arthrodesis (17.3 N/mm (± 9.9)) (p = 0.009). There was no correlation between BMD and displacement in all loading cycles, ultimate load, and bending stiffness of either procedure (p > 0.05).

Conclusion
Although the bending stiffness of the chevron osteotomy was higher, there was no statistically significant difference between the surgical techniques in mean displacement and ultimate load. The BMD did not influence the overall stability of either reconstruction. Locking plate fixation increases the clinical value of the modified Lapidus arthrodesis by outweighing most of the biomechanical disadvantages in comparison to the proximal chevron osteotomy.