bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions and attitudes of medical oncologists regarding fertility preservation and pregnancy in high‐risk cancer patients: A survey among Canadian medical oncologists
Authors: Alshamsan Bader , Kushnir Igal , Al‐Saadi Sulaiman , Srikanthan Amirrtha 
Published: July 2022

AbstractPurposeInfertility is a critical late toxicity that impacts adolescent and young adult (AYA, ages 15–39 years) cancer survivors. International oncology societies recommend discussing fertility preservation (FP) for all AYA patients, regardless of stage or prognosis. We aim to understand Canadian medical oncologists' perceptions, attitudes, and knowledge toward FP and pregnancy in patients with cancer, including advanced stages and high risk for recurrence.MethodsAn anonymous electronic survey utilizing hypothetical scenarios was sent to medical oncologists in the province of Ontario, Canada. Descriptive statistics were used to summarize all data. Logistic regression models were constructed to identify factors that predicted FP discussions and referrals.ResultsThe survey was received by 91 medical oncologists, and the response rate was 44%. Fifty‐eight percent of respondents offer FP for all patients. Physicians are more likely to refer patients for FP before curative intent therapy than before palliative chemotherapy (95% vs. 39.5%, p < 0.001). Most respondents (86%) are comfortable discussing FP; however, only 31% self‐reported feeling up‐to‐date on knowledge of current FP methods. Female physicians were more likely to report up‐to‐date knowledge and confidence discussing FP with patients. Forty percent of respondents identified that concerns about the welfare of the resulting offspring should not be a cause for denying patients assistance in reproduction.ConclusionThere is a significant difference in physician attitude toward offering FP based on the cancer stage. Increased awareness of standard of care guidelines and resources for difficult situations may improve the frequency of discussions about FP in motivated cancer patients.
Mutational landscape and clinical outcome of pediatric acute myeloid leukemia with 11q23/KMT2A rearrangements
Authors: Yuen Ka‐Yuk , Liu Yong , Zhou Yong‐Zhuo , Wang Yin , Zhou Dun‐Hua , Fang Jian‐Pei , Xu Lu‐Hong 
Published: July 2022

AbstractBackgroundAlterations of 11q23/KMT2A are the most prevalent cytogenetic abnormalities in acute myeloid leukemia (AML) and the prognostic significance of 11q23/KMT2A‐rearranged AML based on various translocation partners varies among different studies. However, few studies evaluated the molecular characteristics of 11q23/KMT2A‐rearranged pediatric AML. We aim to analyze the mutational landscape of 11q23/KMT2A‐rearranged AML and assess their prognostic value in outcomes.MethodsThe mutational landscape and clinical prognosis of 105 children with 11q23/KMT2A‐rearranged AML in comparison with 277 children with non‐11q23/KMT2A‐rearranged AML were analyzed using publicly accessible next‐generation sequencing data from Therapeutically Applicable Research to Generate Effective Treatments (TARGET) dataset.ResultsPediatric AML patients with 11q23/KMT2A‐rearrangements harbored a low number of mutations (Median, 1 mutation/patient, range, 1‐22), 58% of which involved in RAS pathway mutations (KRAS, NRAS, and PTPN11) and 10.5% of which comprised of SETD2 mutations. Compared with non‐11q23/KMT2A‐rearranged AML, the incidence of KRAS (32.4% vs. 10.1%, P〈0.001) and SETD2 (10.5% vs. 1.4%, P=0.001) gene mutations in 11q23/KMT2A‐rearranged AML was significantly higher. Both KRAS and SETD2 mutations occurred more often in t(10;11)(p12;q23). KRAS mutations were correlated with worse 5‐year event‐free survival [EFS] (Plog‐rank = 0.001) and 5‐year overall survival [OS] (Plog‐rank = 0.009) and the presence of SETD2 mutations increases the 5‐year relapse rate (PGray = 0.004). Multivariate analyses confirmed KRAS mutations in 11q23/KMT2A‐rearranged AML as an independent predictor for poor EFS (hazard ratio [HR] = 2.10, P=0.05) and OS (HR = 2.39, P=0.054).ConclusionOur findings show that pediatric patients with 11q23/KMT2A rearrangements have characteristic mutation patterns and varying clinical outcomes depending on different translocation partners, which could be utilized to develop more accurate risk stratification and tailored therapies.
Gender differences in factors that facilitate successful therapeutic progress and outcome: A pilot study
Authors: Arora Saachi , Bhatia Sangeeta 
Published: July 2022

AbstractThe current study aims to explore gender differences in factors that facilitate successful therapeutic progress and outcome in the process of psychotherapy. The study was conducted in order to facilitate gender‐sensitive psychotherapy. In order to ascertain the objectives, the sample was collected from individuals who have either experienced or are experiencing psychotherapy as clients. In total, 20 females and 20 males were selected for participation in the study. The data were collected through an online mode. Informed consent was obtained from all clients. The tools used in the study were Session Rating Scale and Session Impacts Scale. The tools were used to assess the factors that determine therapeutic progress and outcomes. Information obtained on these tools was recorded and assessed through quantitative data analysis. Participants were also assessed qualitatively by asking them to describe any major events or important impacts that occurred as a result of psychotherapy. Qualitative responses were then recorded and analysed using content analysis in order to explore the subjective experiences of participants which contributed to their recovery. The findings indicated that males and females equally value the importance of therapeutic alliance between the therapist and client, and agreement on goals and methods. Males and females perceive task and relationship‐oriented factors as helpful in therapy. The relationship factors include being supported and encouraged in therapy, and feeling validated and understood by the therapist. The task‐oriented factors include tools used in therapy, definition of problems and setting therapeutic goals. Males tend to be more sensitive towards factors that inhibit the therapeutic process in comparison with females. Males experience the feeling of “something missing” in therapy sessions more than females. Overall, the findings of this study enhance the understanding of factors that aid recovery in the psychotherapy process for males and females.
Effects of wheat flour with different farinograph and pasting characteristics on the surface tackiness of frozen cooked noodles
Authors: Zhang Ya‐Ru , Wang Yuan‐Hui , Shen Jin‐Qi , Guo Yu‐Ying , Fei Ying‐Xiang , Yu Xiao‐Yu , Zhang Guo‐Zhi , Guo Wei‐Min , Yan Mei‐Hui 
Published: July 2022

AbstractBackground and ObjectivesThe sticky surface of cooked noodles seriously reduces consumer acceptance. This study investigates the effects of 12 wheat flour samples with different farinograph and pasting characteristics on the texture, sensory properties, and surface tackiness of recooked frozen cooked noodles (FCNs).FindingsThe recooked FCNs made of flour sample 1# with long dough stability time (DST) and high farinograph quality number (FQN) had a low surface tackiness (411 g) and high evaluation score (87). Meanwhile, wheat flour (sample 12#) with high peak viscosity (PV) had a proper degree of starch gelatinization, which would bring a low surface tackiness to FCNs. FCNs (sample 1#) had a high water‐holding capacity (T21 = 0.14 ms) and low unbound water content (A23 = 1.38%), and they had a dense internal gluten network structure.ConclusionsThe dense structure formed by protein and starch contributed to reducing the surface tackiness of FCNs after recooking and storing. Noodles factories should choose wheat flour which has long DST, high FQN, and high PV as raw material when producing FCNs.Significance and NoveltyThis study provides important information on choosing wheat flours suitable for making FCNs of high quality.
Aging characteristics of rice dried using microwave at 915 MHz frequency
Authors: Bruce Rebecca M. , Atungulu Griffiths G. , Sadaka Sammy , Mauromoustakos Andy 
Published: July 2022

AbstractBackground and ObjectivesRice aging is an intrinsic phenomenon that leads to physicochemical changes in rice kernels. The goal of this study is to determine the physicochemical properties of rice dried using a 915 MHz microwave and then aged. Two rice cultivars, a medium grain cultivar Titan and long grain hybrid cultivar XL753, with a harvest moisture content of 20% ± 1% (wet basis) were used for the study. The rice samples were treated with two different drying methods, natural air drying as control and microwave heating at 915 MHz frequency followed by tempering and natural air cooling at 25°C and 56% relative humidity (RH). Microwave‐dried samples were treated at specific energies ranging from 360 to 630 kJ/kg of initial wet grain mass (kJ/kg‐grain). Head rice samples were stored for 6 months at 4°C and 25°C representing nonaged and aged samples, respectively. Physicochemical properties of the samples were determined.FindingsAged microwave‐dried rice had significantly higher setback viscosity, cooked rice hardness and gumminess, and significantly lower peak viscosity and solid loss than nonaged rice. The changes in the viscosity profiles of aged microwave‐dried rice were generally similar to the trends recorded for aged control rice. Furthermore, aging significantly increased the water uptake and kernel elongation ratio of microwave‐dried rice cultivar XL753 but had no significant impact on rice cultivar Titan. Statistical models indicate that the solid loss of microwave‐dried rice decreases by 0.083% while the final viscosity, kernel elongation ratio, and hardness increase by 30 cP, 0.014, and 41 g respectively, with every degree Celsius increase in aging temperature (between 4°C and 25°C), when all other variables are kept constant. Also, aged microwave‐dried rice that were treated at 360 and 525 kJ/kg‐grain were practically equivalent in terms of hardness and solid loss.ConclusionsNatural aging of microwave‐dried rice (dried at 915 MHz frequency) led to changes in some physicochemical properties which were generally similar to the aging patterns of the control rice. Microwave specific energy of 525 kJ/kg‐grain is recommended for rice drying because it produces rice with desirable drying and aging properties.Significance and NoveltyThis study provides processing recommendations that can be used to select microwave parameters for rice drying, which will achieve desirable rice properties.
Atrial fibrillation andWolff–Parkinson–Whitesyndrome: A double blow for the cardiologist
Authors: Bazoukis George , Papasavvas Elias , Pavlou Marios , Georgiou Panagiota , Kapetis Lorentzos , Patestos Dimitrios , Vlachos Konstantinos , Saplaouras Athanasios , Letsas Konstantinos P. , Efremidis Michael , Tsielepis Michalis 
Published: July 2022

AbstractElectrocardiographic findings including irregularity of the rhythm, a very rapid ventricular response, and the presence of a delta wave should raise the suspicion of pre‐excited atrial fibrillation with a rapid ventricular response. Urgent cardioversion is needed due to the risk of sudden cardiac death.
The Influence of Coordination Mode on the Redox Properties of Copper Complexes with Aβ(3‐16) and Its Pyroglutamate Counterpart pAβ(3‐16)
Authors: Wiloch Magdalena Z. , Baran Natalia , Jönsson‐Niedziółka Martin 
Published: July 2022

AbstractSenile plaques are a hallmark of Alzheimer's disease. The plaques are mainly composed of small peptides from the β‐amyloid (Aβ) family which differ in how they bind copper ions and thus in their properties. pAβ(3‐42) species and its Aβ(3‐42) precursor are found in significant proportion in the plaques; however, their complexes with copper ions are hardly explored. The electrochemical response of the copper complexes with N‐truncated Aβ(3‐16) and its pyroglutamate counterpart pAβ(3‐16) was investigated using cyclic voltammetry. Results obtained in physiological pH (pH∼7.4) show that Cu(II) ions in these peptides undergo reduction Cu(II)/Cu(I) at a potential (Ef)∼0.05 V which in other peptides have been shown to enhance production of reactive oxygen species. Here, a voltammetric study, performed at pH below and above 7.4, reveals the effects of coordination modes on the observed redox processes. The conclusions are important for a better understanding of the pathogenesis of Alzheimer's disease.
Single‐atom catalysis for carbon neutrality
Authors: Wang Ligang , Wang Dingsheng , Li Yadong 
Published: July 2022

AbstractCurrently, more than 86% of global energy consumption is still mainly dependent on traditional fossil fuels, which causes resource scarcity and even emission of high amounts of carbon dioxide (CO2), resulting in a severe “Greenhouse effect.” Considering this situation, the concept of “carbon neutrality” has been put forward by 125 countries one after another. To achieve the goals of “carbon neutrality,” two main strategies to reduce CO2emissions and develop sustainable clean energy can be adopted. Notably, these are crucial for the synthesis of advanced single‐atom catalysts (SACs) for energy‐related applications. In this review, we highlight unique SACs for conversion of CO2into high‐efficiency carbon energy, for example, through photocatalytic, electrocatalytic, and thermal catalytic hydrogenation technologies, to convert CO2into hydrocarbon fuels (CO, CH4, HCOOH, CH3OH, and multicarbon [C2+] products). In addition, we introduce advanced energy conversion technologies and devices to replace traditional polluting fossil fuels, such as photocatalytic and electrocatalytic water splitting to produce hydrogen energy and a high‐efficiency oxygen reduction reaction (ORR) for fuel cells. Impressively, several representative examples of SACs (includingd‐,ds‐,p‐, andf‐blocks) for CO2conversion, water splitting to H2, and ORR are discussed to describe synthesis methods, characterization, and corresponding catalytic activity. Finally, this review concludes with a description of the challenges and outlooks for future applications of SACs in contributing toward carbon neutrality.
Inter‐ and intraobserver agreement in whole‐slide digital ThinPrep samples of low‐grade squamous lesions of the cervix uteri with known high‐risk HPV status: A multicentric international study
Authors: Kholová Ivana , Negri Giovanni , Nasioutziki Maria , Ventura Laura , Capitanio Arrigo , Bongiovanni Massimo , Cross Paul A. , Bourgain Claire , Edvardsson Henrik , Granados Rosario , Lipiński Artur , Obermann Ellen Christina , Pinamonti Maurizio , Sidlova Henrieta , Strojan Fležar Margareta , van Kemenade Folkert J. , Vrdoljak‐Mozetic Danijela , Fassina Ambrogio , Cochand‐Priollet Beatrix 
Published: July 2022

BackgroundHigh‐risk human papilloma virus (HR HPV) testing and liquid‐based cytology are used for primary cervical screening. Digital cytology, based on whole‐slide scanned samples, is a promising technique for teaching and diagnostic purposes. The aim of our study was to evaluate the interobserver and intraobserver variation in low‐grade squamous lesions, HR HPV status bias, and the use of whole‐slide scanned digital cervical cytology slides.MethodsFifteen expert cytopathologists evaluated 71 digitalized ThinPrep slides (31 atypical squamous cells of undetermined significance [ASC‐US], 21 negative for intraepithelial lesion or malignancy, and 19 low‐grade squamous intraepithelial lesion cases). HR HPV data were accessible only in the second round.ResultsIn interobserver analysis, Kendall’s coefficient of concordance was 0.52 in the first round and 0.58 in the second round. Fleiss’ kappa values were 0.29 in the first round and 0.31 in the second round. In the ASC‐US category, Fleiss kappa increased from 0.19 to 0.22 in the second round and the increase was even higher expressed by Kendall’s coefficient: from 0.42 to 0.52. In intraobserver analysis, personal scores were higher in the second round.ConclusionsThe interobserver and intraobserver variability in low‐grade squamous lesions was within fair agreement values in the present study, in line with previous works. The comparison of two rounds showed that expert cytopathologists are generally unbiased by the knowledge of HR HPV data, but that being informed of the HR HPV status leads to a better agreement. Stain quality and back discomfort were highlighted as factors affecting digital cytopathology use.
Enhanced electrocatalytic nitrate reduction to ammonia using plasma‐induced oxygen vacancies in CoTiO3 − x nanofiber
Authors: Fan Xiaoya , Liang Jie , Zhang Longcheng , Zhao Donglin , Yue Luchao , Luo Yongsong , Liu Qian , Xie Lisi , Li Na , Tang Bo , Kong Qingquan , Sun Xuping 
Published: July 2022

AbstractElectrochemical nitrate (NO3−) reduction is a green and economic route for ammonia (NH3) synthesis. However, this conversion suffers from low NH3 selectivity due to strong competition from other NO3− reduction pathways. Here, we report that a plasma‐induced defective CoTiO3 − x nanofiber with oxygen vacancies acts as an efficient electrocatalyst for NO3− reduction to NH3. In 0.1 M NaOH solution containing 0.1 M NO3−, it is capable of achieving a remarkable NH3 yield of 30.4 mg h–1 mgcat.–1 and a high Faradaic efficiency of 92.6%. The catalyst also shows strong electrochemical stability for a 20‐h electrolysis test. Additionally, a Zn‐NO3− battery using CoTiO3 − x as the cathode catalyst offers a peak power density of 5.04 mW cm−2 and a large NH3 yield of 3.08 mg h−1 mgcat.−1. The catalytic mechanism is further discussed by density functional theory calculations.
The dummy‐based trajectory privacy protection method to resist correlation attacks in Internet of Vehicles
Authors: Chen Qiuling , Ye Ayong , Zhao Ziwen , Xiong Jinbo 
Published: July 2022

SummaryExisting dummy‐based trajectory privacy protection schemes do not take into account the correlation of multiple locations and whether the generated trajectory based on dummies matches the user's movement mode, which enables the adversary to identify some dummies. Aiming at this problem, to ensure that the generated trajectories match the movement modes of users, historical query trajectories of users are selected. In this way, the generated dummies on the selected historical query trajectories are based on the location relationship of adjacent time and the background information constraint of the dummy, namely, they should meet the time reachability, the similarity of historical query probability and the maximum in‐degree. Security analysis shows that the proposed scheme effectively perturbs the spatiotemporal correlation between the real location and dummies. Furthermore, the proposed scheme is compared with the existing schemes in terms of single‐point location exposure risk and trajectory exposure risk, and the experimental results indicate that the proposal has significant improvement in location privacy protection of the user.
Bacterial Aryl Sulfotransferases in Selective and Sustainable Sulfation of Biologically Active Compounds using Novel Sulfate Donors
Authors: Brodsky Katerina , Káňová Kristýna , Konvalinková Dorota , Slámová Kristýna , Pelantová Helena , Valentová Kateřina , Bojarová Pavla , Křen Vladimír , Petrásková Lucie 
Published: July 2022

AbstractRegioselective sulfation of bioactive compounds is a vital and scarcely studied topic in enzyme‐catalyzed transformations and metabolomics. The major bottleneck of enzymatic sulfation consists in finding suitable sulfate donors. In this regard, 3′‐phosphoadenosine 5′‐phosphosulfate (PAPS)‐independent aryl sulfotransferases using aromatic sulfate donors are a favored choice due to their cost‐effectiveness. This work presents a unique study of five sulfate donors differing in their leaving group pKa values with a new His‐tagged construct of aryl sulfotransferase from Desulfitobacterium hafniense (DhAST‐tag). DhAST‐tag was purified to homogeneity and biochemically characterized. Two new donors (3‐nitrophenyl sulfate and 2‐nitrophenyl sulfate) were synthesized. The kinetic parameters of these and other commercial sulfates (4‐nitrophenyl, 4‐methylumbelliferyl, and phenyl) revealed large differences with respect to the structure of the leaving group. These donors were screened for the sulfation of selected flavonoids (myricetin, chrysin) and phenolic acids (gallate, 3,4‐dihydroxyphenylacetate). The donor impact on the sulfation regioselectivity and yield was assessed. The obtained regioselectively sulfated compounds are authentic human metabolites required as standards in clinical trials.
A high‐gain multi‐input single‐output switched quasi‐Z‐source converter for the integration of multiple renewable energy sources
Authors: Subramaniam Kalpanadevi , Muthusamy Suganthi , Periyasamy Rajendran 
Published: July 2022

AbstractAiming to integrate distinct renewable energy sources and to obtain the benefits of quasi‐Z‐source converter, voltage doubler rectifier, and switched capacitor converter, a high‐gain multi‐input single‐output switched quasi‐Z‐source converter (SqZSC) with a multi‐input high‐frequency transformer is proposed. The proposed SqZSC fed three‐phase six‐level (TPSL) micro‐inverter is designed to integrate multiple small‐scale renewable energy sources such as wind, photovoltaic systems, and fuel cells with the utility grid. Compared with the other topology of Z‐source converter, the designed converter can offer a high boost factor, low conversion losses, low voltage and current stress across the main chopping switches, and the one‐port impedance network. The design, working principle, voltage and current stress of the chopping switches, experimental results, and comparison with the other topology of ZSC are presented. Finally, the results of a 1200‐W prototype model are given to authenticate the steady‐state and dynamic performance of the proposed multi‐input single‐output SqZSC.
Artificial intelligence‐enabled distributed energy conservative model for mobile internet of things using software‐defined network
Authors: Haseeb Khalid , Islam Naveed , Ahmed Imran , Hassan Mohammad Mehedi , Jeon Gwanggil 
Published: July 2022

SummaryThe Internet of things (IoT) is an emerging technology for many smart applications due to its efficient resource utilization, scalability, and fast interaction with the physical world. Software‐defined network (SDN), on the other hand, provides dynamic services for controlling and managing real‐time systems. However, collected data are sent to a central location, which requires balancing energy resources with redundant channels to maximize the availability of smart functions. Furthermore, the IoT network faces numerous security vulnerabilities as a result of its open communication space, including malicious messages and privacy concerns. Thus, this paper presents a distributed and artificial intelligence‐based energy‐efficient model for IoT‐SDN architecture, which aims to improve data aggregation and power distribution. It also provides security and authentication for smart communication systems. First, the proposed model introduces the heuristic evaluation using artificial intelligence and decreases the power consumption for sensor nodes in a real‐time system. Moreover, it optimizes the paradigm of distributed processing and efficiently increases the green energy technology with nominal management costs using the mobile edges. Second, the aggregated data of the environment is secured using a centralized controller to attain the most trustworthy data availability. The experimental results show a comparative analysis of the proposed model in terms of energy efficiency, packet drop ratio, and waiting time by 22%, 23%, 40%, and 49% as compared to existing studies.