bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional outcomes of all-inside arthroscopic anterior talofibular ligament repair with loop suture versus free-edge suture
Authors: Feng Shi-Ming , Shao Chang-Qing , Sun Qing-Qing , Oliva Francesco , Maffulli Nicola 
Published: November 2022

Abstract
Background
Anatomic repair of anterior talofibular ligament (ATFL) is used to manage chronic lateral ankle instability (CLAI). However, the optimal suture configuration used to repair the ATFL is not yet determined. It remains unclear whether suture configuration affects clinical outcomes in such patients.

Purpose
To compare the functional outcomes of all-inside arthroscopic ATFL repair using either a loop suture and or a free-edge suture configuration in CLAI patients.

Study Design
Cohort study; Level of evidence, 3.

Methods
This retrospective cohort study included 71 patients with CLAI who had undergone an all-inside arthroscopic ATFL repair procedure with either loop suture (n = 36) or free-edge suture (n = 35) from February 2016 to July 2018. Comparable pre-operatively, the Visual analogy score (VAS), American Orthopedic Foot and Ankle Society scoring system (AOFAS), Karlsson Ankle Functional Score (KAFS) scoring system, Anterior Talar Translation (ATT) and Active Joint Position Sense (AJPS) were used to evaluate postoperative ankle function.

Results
There were no postoperative wound complications, implant reactions, or neurological or vascular injuries. Postoperative hospitalization, VAS, AOFAS, KAFS, AJPS and the time of return to sport were similar between the loop suture group and free-edge suture group. Requiring a longer procedure time, patients with loop suture configuration achieved better ATT.

Conclusion
All-inside arthroscopic ATFL repair procedure for CLAI treatment provides better ATT and comparable functional outcomes when a loop suture configuration is used instead of a free-edge suture configuration. A statistical difference in ATT was observed. Given the relatively short follow-up, it is questionable whether this will have any clinical relevance.
Totally endoscopic non-robotic excision of aortic valve fibroelastoma: a case report
Authors: Batool Sadia , Patoir Arnaud , de Meaux Amelie , Vola Marco 
Published: November 2022

Abstract
Background
Papillary fibroelastomas (PFEs) are a rare subtype of benign primary cardiac tumours, which are most commonly found on the aortic valve. Although median sternotomy is still used frequently there has been different attempts to remove the aortic valve PFEs minimally invasively using robotic and Mini sternotomy approach.

Case presentation
We report herein a case of totally endoscopic non robotic removal of PFE of aortic valve.

Conclusions
The encouraging intra and post-operative outcomes and fast recovery using totally endoscopic approach for removal of PFE shows the potential benefits of this technique.
Late-onset rheumatoid arthritis has a similar time to remission as younger-onset rheumatoid arthritis: results from the Ontario Best Practices Research Initiative
Authors: Li Xiuying , Cesta Angela , Movahedi Mohammad , Bombardier Claire 
Published: November 2022

Abstract
Background
The prevalence of rheumatoid arthritis (RA) in persons 60 years or older is estimated to be 2%. Late-onset rheumatoid arthritis (LORA) is traditionally defined as the onset of RA after the age of 60 years. Compared to younger-onset rheumatoid arthritis (YORA) which occurs before the age of 60 years, LORA has unique characteristics and disease manifestations. To date, few reports have addressed LORA and the prognosis of LORA patients remains unclear. We compared the clinical characteristics, time to remission and treatment regimen at remission between LORA and YORA patients.

Methods
This prospective cohort study used a registry database in Ontario, Canada from 2008 to 2020. Patients were included if they had active rheumatoid arthritis (RA) disease (≥1 swollen joint) and were enrolled within 1 year of diagnosis. LORA was defined as a diagnosis of RA in persons 60 years and older and YORA as a diagnosis of RA in persons under the age of 60. Remission was defined by Disease Activity Score 28 (DAS28) ≤2.6. A multivariable Cox proportional hazards model was used to estimate time to remission.

Results
The study included 354 LORA patients and 518 YORA patients. The mean (standard deviation) baseline DAS28 score was 5.0 (1.3) and 4.8 (1.2) in LORA and YORA patients, respectively (p=0.0946). Compared to YORA patients, the hazard ratio for remission in LORA patients was 1.10 (95% confidence interval 0.90 to 1.34 p=0.36) after adjusting for other prognostic factors. For patients who reached remission, LORA patients were less likely to be on a biologic or Janus kinase (JAK) inhibitor (16% vs. 27%) and more likely to be on a single conventional synthetic disease-modifying anti-rheumatic drugs (csDMARD) (34% vs. 27%) than YORA patients (p=0.0039).

Conclusion
LORA and YORA patients had similar prognosis in terms of time to remission. At remission, LORA patients were more likely to be on a single csDMARD without a biologic or JAK inhibitor.
Prognostic significance of systemic immune-inflammation index in patients with nasopharyngeal carcinoma: a meta-analysis
Authors: Zeng Zesheng , Xu Shengen , Wang Dingting , Qin Gang 
Published: November 2022

AbstractBackgroundPrevious studies have investigated the prognostic value of the systemic immune-inflammation index (SII) in nasopharyngeal carcinoma (NPC). However, the results have been inconsistent. Therefore, this study aims to investigate the prognostic significance of SII in NPC through a meta-analysis.MethodsThe PubMed, Web of Science, Embase, and Cochrane Library databases were thoroughly searched. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to evaluate the prognostic value of the SII for survival outcomes.ResultsA total of six studies comprising 2169 patients were included in the meta-analysis. Pooled analyses indicated that a high SII was significantly associated with worse overall survival (OS) (HR= 1.69, 95%CI= 1.36–2.09,P< 0.001) and progression-free survival (PFS) (HR= 1.60, 95%CI= 1.29–1.98,P< 0.001) in patients with NPC. Subgroup analysis showed that SII was a significant prognostic marker for PFS but not for OS in NPC.ConclusionOur meta-analysis demonstrated that a high SII could be an efficient prognostic indicator of OS and PFS in NPC. In our opinion, SII could be used to predict long-term and short-term outcomes in patients with NPC. Furthermore, we suggest that SII be applied to help individual patients with NPC assess the prognostic risk.Systematic review registrationPROSPERO CRD42022321570
A systematic review of the purposes of Blockchain and fog computing integration: classification and open issues
Authors: Alzoubi Yehia Ibrahim , Gill Asif , Mishra Alok 
Published: November 2022

AbstractThe fog computing concept was proposed to help cloud computing for the data processing of Internet of Things (IoT) applications. However, fog computing faces several challenges such as security, privacy, and storage. One way to address these challenges is to integrate blockchain with fog computing. There are several applications of blockchain-fog computing integration that have been proposed, recently, due to their lucrative benefits such as enhancing security and privacy. There is a need to systematically review and synthesize the literature on this topic of blockchain-fog computing integration. The purposes of integrating blockchain and fog computing were determined using a systematic literature review approach and tailored search criteria established from the research questions. In this research, 181 relevant papers were found and reviewed. The results showed that the authors proposed the combination of blockchain and fog computing for several purposes such as security, privacy, access control, and trust management. A lack of standards and laws may make it difficult for blockchain and fog computing to be integrated in the future, particularly in light of newly developed technologies like quantum computing and artificial intelligence. The findings of this paper serve as a resource for researchers and practitioners of blockchain-fog computing integration for future research and designs.
Influence of multiple stenoses on thrombosis formation: an in vitro study
Authors: Flores Marcial Helem B. , Choi Jiseob , Ham Donghwi , Kim Junghyun , Jeong Pyeongho , Choi Jinho , Park Woo-Tae 
Published: November 2022

AbstractMultiple lesions in the same vessel is one of the most common situations found in patients suffering from cardiovascular diseases, this complicates not only the assessment of the severity of each one but also their treatment. To date, the effect of multiple stenoses on different parameters has been simulated by numerical studies. Few others have implemented in vitro platforms for their investigation. However, visualization of thrombosis formation in this kind of lesion is still needed. This in vitro study monitors the formation of thrombus inside microchannels having one, two, and three stenoses. Whole blood was perfused through each channel at high shear rates (> 12,000 s−1), generating thrombosis. Flow changes across each lesion as well as the final percentage of aggregations were monitored. Thus, the location where total occlusion could be produced was found to be the first stenosis for all the cases. Less flow reaching the second and third stenoses was observed which demonstrates that aggregations were growing at the first one. This was verified by measuring the percentage of aggregations at the end of the test.
Developing and evaluating training for pharmacists to offer a pharmacy-led public health service in primary care
Authors: Peletidi Aliki , Kayyali Reem 
Published: November 2022

AbstractBackgroundCurrently in Greece, no formal organisation offers post-academic education to pharmacists. To improve the clinical practice of pharmacists, there is a need for training that will educate them on how to approach and consult their patients. The study aimed to evaluate the training required by pharmacists to offer a pharmacy-led weight management service in Greece.MethodsThe study consisted of 3 phases. During the first phase educational needs of the participating pharmacists were identified. A pre-training quiz was given consisting of 14 questions to investigate the participating pharmacists’ knowledge on guidance, causes and facts of obesity. The second phase comprised the training design and delivery. The final phase dealt with training evaluation (27 questions in total), which included the perceived rating of knowledge and confidence levels pre- and post-training, and a post-training quiz (the same as the pre-training quiz). The post-evaluation questionnaire and the quiz (pre- and post-training) results were entered into SPSS Version 23 for statistical analysis.ResultsThe mean total quiz score was 6.38 (SD = 2.56) pre-training compared to 11.92 (SD = 1.20) post-training (P < 0.001). Nearly all community pharmacists, 96.2% (n = 25) stated that they had an excellent/good experience and 88.5% (n = 23) strongly agreed/agreed that their expectations were met.ConclusionsTraining delivered was well received and it enhanced participants’ knowledge on the topic. Limitations include the small number of participating pharmacists and investigation of short-term training effects only. Due to the positive outcomes of the training, however, it has the potential to become a model for Greek pharmacists to offer different pharmacy-led public health services.
The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity
Authors: Xiong Yuan , Mi Bo-Bin , Lin Ze , Hu Yi-Qiang , Yu Le , Zha Kang-Kang , Panayi Adriana C. , Yu Tao , Chen Lang , Liu Zhen-Ping , Patel Anish , Feng Qian , Zhou Shuan-Hu , Liu Guo-Hui 
Published: November 2022

AbstractBone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting a variety of cell types, whose activity and interplay must be precisely mediated for effective healing post-injury. Although extensive strides have been made in the understanding of the immune microenvironment processes governing bone, cartilage, and soft tissue regeneration, effective clinical translation of these mechanisms remains a challenge. Regulation of the immune microenvironment is increasingly becoming a favorable target for bone, cartilage, and soft tissue regeneration; therefore, an in-depth understanding of the communication between immune cells and functional tissue cells would be valuable. Herein, we review the regulatory role of the immune microenvironment in the promotion and maintenance of stem cell states in the context of bone, cartilage, and soft tissue repair and regeneration. We discuss the roles of various immune cell subsets in bone, cartilage, and soft tissue repair and regeneration processes and introduce novel strategies, for example, biomaterial-targeting of immune cell activity, aimed at regulating healing. Understanding the mechanisms of the crosstalk between the immune microenvironment and regeneration pathways may shed light on new therapeutic opportunities for enhancing bone, cartilage, and soft tissue regeneration through regulation of the immune microenvironment.
Steroid Profiling in the Amniotic Fluid: Reference Range for 12 Steroids and Interest in 21-Hydroxylase Deficiency
Authors: Pourquet Anne , Teoli Jordan , Bouty Aurore , Renault Lucie , Roucher Florence , Mallet Delphine , Rigaud Chantal , Dijoud Frédérique , Mouriquand Pierre , Mure Pierre-Yves , Sanlaville Damien , Ecochard René , Plotton Ingrid 
Published: November 2022

AbstractContextDetermination of steroid levels in the amniotic fluid gives some insight on fetal adrenal and gonadal functions.ObjectiveOur objectives were to establish reference ranges of 12 steroid levels throughout pregnancy and to compare them with steroid levels from pregnancies with fetuses presenting with 21-hydroxylase deficiency (21OHD).MethodsLiquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was applied to 145 “control” amniotic fluid samples from gynecology activity (12 + 6 to 32 + 4 gestational weeks, GW). The following steroids were analyzed according to gestational age and compared to 23 amniotic fluid samples from fetuses with classic 21OHD confirmed by molecular studies: delta-4-androstenedione (D4), dehydroepiandrosterone (DHEA), 17-hydroxyprogesterone (17OHP), 11-deoxycortisol (11OH), 21-deoxycortisol (21OH), corticosterone, deoxycorticosterone (DOC), testosterone, pregnenolone, 17-hydroxypregnenolone (17Pregn), cortisol, and cortisone. Chromosomal sex was determined by karyotype and gestational age by biometric measurements.ResultsAnalysis of control samples showed a statistically significant difference for D4 and testosterone levels according to fetal sex. Cortisol, corticosterone, and DOC had lower concentrations before 20 GW than after 20 GW, whereas 17Pregn and pregnenolone had higher concentrations before 20 GW. This allowed us to establish age- and sex-dependent reference values. We observed higher 21OH, 17Pregn, D4, and testosterone levels in females with 21OHD than female controls. The ratios 17OHP/17Pregn, D4/DHEA, and 11OH/17OHP appeared discriminant for the diagnosis of 21OHD.ConclusionOur study provides information on fetal steroidogenesis and suggests reference values for 12 steroids during pregnancy. This allows a prenatal diagnosis of 21OHD within 24 hours and might be useful in the diagnosis of other variations of sex development.
Pacing Behavior Development in Adolescent Swimmers: A Large-Scale Longitudinal Data Analysis
Authors: MENTING STEIN GERRIT PAUL , POST AYLIN KIM , NIJENHUIS SEBASTIAAN BENJAMIN , KONING RUUD HANS , VISSCHER CHRIS , HETTINGA FLORENTINA JOHANNA , ELFERINK-GEMSER MARIJE TITIA 
Published: November 2022

ABSTRACT

Purpose
This study aimed to use a large-scale longitudinal design to investigate the development of the distribution of effort (e.g., pacing) in adolescent swimmers, specifically disentangling the effects of age and experience and differentiating between performance levels in adulthood.

Methods
Season best times and 50-m split times of 100- and 200-m freestyle swimmers from five continents were gathered between 2000 and 2021. Included swimmers competed in a minimum of three seasons between 12 and 24 yr old (5.3 ± 1.9 seasons) and were categorized by performance level in adulthood (elite, sub-elite, high-competitive; 100-m: n = 3498 (47% female); 200-m: n = 2230 (56% female)). Multilevel models in which repeated measures (level 1) were nested within individual swimmers (level 2) were estimated to test the effects of age, race experience, and adult performance level on the percentage of total race time spent in each 50-m section (P < 0.05).

Results
In the 100-m, male swimmers develop a relatively faster first 50-m when becoming older. This behavior also distinguishes elite from high-competitive swimmers. No such effects were found for female swimmers. Conversely, more experienced male and female swimmers exhibit a slower initial 50-m. With age and race experience, swimmers develop a more even velocity distribution in the 200-m. Adolescent swimmers reaching the elite level adopt a more even behavior compared with high-competitive. This differentiation occurs at a younger age in female (>13 yr) compared with male (>16 yr) swimmers.

Conclusions
Pacing behavior development throughout adolescence is driven by age-related factors besides race experience. Swimmers attaining a higher performance level during adulthood exhibit a pacing behavior that better fits the task demands during adolescence. Monitoring and individually optimizing the pacing behavior of young swimmers is an important step toward elite performance.
Association of the BB genotype of the ABO gene with the risk of acute myocardial infarction in hospital-based study
Authors: Yousuf Farzana Abubakar , Azam Iqbal , Tareen Asal Khan , Kazmi Khawar , Muhammad Jibran Sualeh , Iqbal Mohammad Perwaiz 
Published: November 2022

Objectives: The ABO gene locus has been identified to be associated with myocardial infarction in patients with coronary heart disease. The primary focus of this hospital-based study was to explore the relationship of ABO blood groups and ABO genotypes with acute myocardial infarction (AMI) in Karachi, Pakistan.
Methods: In a comparative cross-sectional study, an equal number of adult AMI patients and healthy controls (n=275 in each group; age range 30-70 years, both males and females) were recruited from the Aga Khan University and NICVD, Karachi, with informed consent. The blood samples were analyzed for ABO blood groups and other biomarkers. PCR followed by RFLP techniques were employed for determining the ABO genotypes. Multinomial regression was used to evaluate the association of genotypes with the risk of AMI.
Results: Thirteen different combinations of ABO genotypes were observed while the O2O2 and A2A2 genotypes were not detected. No significant association based on the distribution of blood groups A, B, O and AB among AMI patients and healthy individuals was observed. The odds of AMI were 3.32 times in subjects with BB genotype as compared to subjects with OO genotypes after adjustment of age, gender, body mass index, heart rate, total cholesterol, and waist circumference [AOR (95% CI) =3.32 (1.36-8.08), p-value =0.008].
Conclusion: Our hospital-based study indicates that ABO genotype BB was significantly associated with the risk of AMI. This harmful effect of the BB genotype could have a possible relationship with AMI’s development in the Pakistani population.
doi: https://doi.org/10.12669/pjms.39.1.5905
How to cite this: Yousuf FA, Azam I, Tareen AK, Kazmi KA, Muhammad JS, Iqbal MP. Association of the BB genotype of the ABO gene with the risk of acute myocardial infarction in hospital-based study. Pak J Med Sci. 2023;39(1):---------. doi: https://doi.org/10.12669/pjms.39.1.5905
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Splenic artery transposition for hepatic arterial supply in living donor liver transplantation
Authors: Ullah Kaleem , Dogar Abdul Wahab , Uddin Shams , Bilal Hafiz 
Published: November 2022

Objective: To determine the safety and outcome of splenic artery(SA) transposition in extra-anatomic hepatic arterial reconstruction (HAR) in living donor liver transplantation(LDLT).
Methods: We retrospectively compared the outcome of the ten liver recipients who underwent HAR with the transposed splenic artery (SA group) with a matched cohort of 40 recipients who underwent HAR with the standard hepatic artery (HA group) between March, 2019 and December, 2020 at liver transplantation department, Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Pakistan. The comparison of recipients’ and donor demographics, operative and graft characteristics, post-operative labs, Doppler ultrasound(USG) findings, and complications, along with 30-day mortality, and 1-year survival were reported for both groups.
Results: The mean age of patients in the SA group was 42.80±7.510 and in the HA group was 43.73±8.171 years. The common indication of LDLT was viral hepatitis in both groups. The operative duration was longer in the SA group (597.50±41.3156 min) than in the HA group (530.75±66.502 min) with a significant p-value= 0.004. Similarly, blood loss was also more in the SA group (1635±226.139 ml) than in the HA group (1477.50±270.316 ml) (p-value= 0.096). The incidence of biliary and vascular complications, early allograft dysfunction, acute cellular rejection, 30-day mortality, and 1-year survival were comparable in both groups. Post-operatively splenectomy was not needed in any SA group recipients.
Conclusion: The SA is easily approachable, suitable, and safe for HAR in the difficult situation of hepatic arterial flow inadequacy during LDLT due to its appropriate length, and good blood flow.
doi: https://doi.org/10.12669/pjms.39.1.6351
How to cite this: Ullah K, Dogar AW, Shams-ud-Din, Bilal H. Splenic artery transposition for hepatic arterial supply in living donor liver transplantation. Pak J Med Sci. 2023;39(1):---------. doi: https://doi.org/10.12669/pjms.39.1.6351
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.