bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiographic predictors for MRONJ in oncologic patients undergoing tooth extraction
Authors: Moreno-Rabié Catalina , Lapauw Laurence , Gaêta-Araujo Hugo , Ferreira-Leite André , Coucke Wim , van den Wyngaert Tim , Jacobs Reinhilde 
Published: July 2022

AbstractTooth extraction is a risk factor for the development of osteonecrosis of the jaw following treatment with antiresorptive drugs (ARDs), but not all extraction sites develop this pathology. Therefore, we aimed to identify local radiographic predictors of Medication-Related Osteonecrosis of the Jaw (MRONJ) in panoramic images of oncologic patients undergoing tooth extraction. Based on a retrospective longitudinal cohort study design, patients were included if undergoing one or more tooth extraction, with at least one administration of ARDs, and presence of pre- and post-operative panoramic radiographs. After data collection, blinded and independent observations were performed. Eleven distinct imaging-related parameters were assessed preoperatively and five postoperatively, at each extraction site. A case–control and subgroup analysis assessing MRONJ development was performed. Significance level is set to 0.05 (5%). A total of 77 oncologic patients were selected, undergoing 218 tooth extractions, from which 63 teeth (29%) in 39 patients (51%) developed MRONJ. Results showed that patients developed significantly more MRONJ with longer ARD treatment (p = 0.057), teeth with absent and incomplete endodontic fillings with caries, widened periodontal ligament space and/or periapical lesions (p = 0.005), and sclerotic and heterogenous bone patterns (p = 0.005). In conclusion, tooth extraction sites presenting with infections and bone sclerosis are at higher risk to develop MRONJ.
Structural analysis of traditional Chinese complex puzzle locks
Authors: Shi Kan , Wang Ming Jie , Zhang Yang , Hsiao Kuo Hung , Yao Yan An 
Published: July 2022

AbstractThe development of barbed-spring locks in ancient China has a history of more than 2000 years. With the development of the design and manufacturing techniques in ancient China, the safety of locks has gotten better and better. Since the seventeenth century, the puzzle lock, with a complicated structure and a high difficulty in opening, was gradually developed and used. The puzzle lock needs specific steps to be opened. Based on the difficulty of the opening process, traditional Chinese puzzle locks can be partition into two sorts, namely, general puzzle locks and complex puzzle locks. As the structure of the puzzle lock will change during the opening process, the puzzle lock belongs to the reconfigurable mechanism. In this paper, a method of topology matrix is provided to analyze the structure of the complex puzzle lock during systematical operation. Firstly, the characteristics and types of general puzzle locks are explained, and then the topology matrix representation is introduced. Finally, four complex puzzle locks are taken as examples, to illustrate the opening process. There are various types of complex puzzle locks, and the mechanism designs are quite ingenious and interesting, which shows the extraordinary technique and ingenuity of the ancient craftsmen.
Establishment of a social conditioned place preference paradigm for the study of social reward in female mice
Authors: Harda Zofia , Chrószcz Magdalena , Misiołek Klaudia , Klimczak Marta , Szumiec Łukasz , Kaczmarczyk-Jarosz Maria , Rodriguez Parkitna Jan 
Published: July 2022

AbstractSocial interactions can be and often are rewarding. The effect of social contact strongly depends on circumstances, and the reward may be driven by varied motivational processes, ranging from parental or affiliative behaviors to investigation or aggression. Reward associated with nonreproductive interactions in rodents is measured using the social conditioned place preference (sCPP) paradigm, where a change in preference for an initially neutral context confirms reinforcing effects of social contact. Here, we revised the sCPP method and reexamined social reward in adult female mice. Contrary to earlier studies, we found that robust rewarding effects of social contact could be detected in adult (14-week-old) female C57BL/6 mice when the sCPP task was refined to remove confounding factors. Strikingly, the rewarding effects of social interaction were only observed among female siblings who remained together from birth. Contact with same-age nonsiblings was not rewarding even after 8 weeks of cohousing. Other factors critical for the social reward effect in the sCPP paradigm included the number of conditioning sessions and the inherent preference for contextual cues. Thus, we show that social interaction is rewarding in adult female mice, but this effect strictly depends on the familiarity of the interaction partners. Furthermore, by identifying confounding factors, we provide a behavioral model to study the mechanisms underlying the rewarding effects of nonreproductive social interaction in adult mice.
Benzylamines as highly potent inhibitors of the sterol biosynthesis pathway in Leishmania amazonensis leading to oxidative stress and ultrastructural alterations
Authors: de Macedo-Silva Sara Teixeira , Visbal Gonzalo , Souza Gabrielle Frizzo , dos Santos Mayara Roncaglia , Cämmerer Simon B. , de Souza Wanderley , Rodrigues Juliany Cola Fernandes 
Published: July 2022

AbstractLeishmaniasis is a neglected disease caused by protozoan parasites of the Leishmania genus. Benzylamines are a class of compounds selectively designed to inhibit the squalene synthase (SQS) that catalyzes the first committed reaction on the sterol biosynthesis pathway. Herein, we studied seven new benzylamines (SBC 37–43) against Leishmania amazonensis. After the first screening of cell viability, two inhibitors (SBC 39 and SBC 40) were selected. Against intracellular amastigotes, SBC 39 and SBC 40 presented selectivity indexes of 117.7 and 180, respectively, indicating high selectivity. Analysis of the sterol composition revealed a depletion of endogenous 24-alkylated sterols such as episterol and 5-dehydroepisterol, with a concomitant accumulation of fecosterol, implying a disturbance in cellular lipid content. This result suggests a blockade of de novo sterol synthesis at the level of SQS and C-5 desaturase. Furthermore, physiological analysis and electron microscopy revealed three main alterations: (1) in the mitochondrion; (2) the presence of lipid bodies and autophagosomes; and (3) the appearance of projections in the plasma membrane. In conclusion, our results support the notion that benzylamines have a potent effect against Leishmania amazonensis and should be an exciting novel pharmaceutical lead for developing new chemotherapeutic alternatives to treat leishmaniasis.
A novel PID controller for BLDCM speed control using dual fuzzy logic systems with HSA optimization
Authors: Wang Tingting , Wang Hongzhi , Wang Chuhang , Hu Huangshui 
Published: July 2022

AbstractIn order to enhance the speed control performance of the brushless DC motor (BLDCM), a novel proportion integration differentiation (PID) is proposed in this paper by using dual fuzzy logic systems (FLSs) with harmony search algorithm (HSA) optimization, which is called DFPID-HSA. Firstly, the FLS1 in DFPID-HSA locks the three coefficients of the PID controller in an extensive range on the basis of the system error and error change rate. Then, the FLS2 is optimized by HSA (HSA-F2) to obtain the precise correction of the three coefficients. To get the optimal global harmony better, the improved dynamic adjustment mode is used for the pitch adjustment rate (PAR) and distance bandwidth (BW) in HSA, and the triple selection method is adopted in the composition harmony section to realize the global search. Finally, DFPID-HSA provides the optimal supply control signal to BLDCM so that it can control the speed effectively. Moreover, the stability of the system is analyzed by the pole, Lyapunov, and Nyquist determination methods. And the sensitivity analysis of DFPID-HSA is carried out under the condition of different motor’s mechanical parameters to check its robustness. In addition, the superiority of DFPID-HSA is verified by MATLAB simulation and experiment platform.
Pollution severity-regulated effects of roof strategies on China’s winter PM2.5
Authors: Wang Fan , Carmichael Gregory R. , Zhang Xiaorui , Xiao Xiang , Gao Meng 
Published: July 2022

AbstractUrbanization took place rapidly over recent decades and is expected to continue in the future, producing a series of environmental issues, including heat stress. Cool roof and green roof strategies have been adopted in a number of megacities to mitigate urban heat and carbon emissions, yet China is lagging behind developed countries in the implementation. One reason is the lack of careful and thoughtful assessment of potential effects of roof strategies, including their influences on winter PM2.5. With numerical simulations in this study, we assess how cool and green roof strategies affect winter PM2.5pollution in North China, and we find that adoptions of cool roofs tend to aggravate PM2.5pollution in lightly polluted regions. When PM2.5pollution worsens, the negative effects of cool roofs are likely to be diminished. Green roofs cause less enhancements of PM2.5pollution as a result of inhibited evapotranspiration in winter. We demonstrate that the effects of roof strategies are regulated by pollution severity and conclude that green roofs with suppressed evapotranspiration and thus weaker penalty on winter PM2.5pollution seem to be better choices given the current pollution severity level in China, especially for regions suitable for growth of broadleaf plants.
Cross-Platform Omics Prediction procedure: a statistical machine learning framework for wider implementation of precision medicine
Authors: Wang Kevin Y. X. , Pupo Gulietta M. , Tembe Varsha , Patrick Ellis , Strbenac Dario , Schramm Sarah-Jane , Thompson John F. , Scolyer Richard A. , Muller Samuel , Tarr Garth , Mann Graham J. , Yang Jean Y. H. 
Published: July 2022

AbstractIn this modern era of precision medicine, molecular signatures identified from advanced omics technologies hold great promise to better guide clinical decisions. However, current approaches are often location-specific due to the inherent differences between platforms and across multiple centres, thus limiting the transferability of molecular signatures. We present Cross-Platform Omics Prediction (CPOP), a penalised regression model that can use omics data to predict patient outcomes in a platform-independent manner and across time and experiments. CPOP improves on the traditional prediction framework of using gene-based features by selecting ratio-based features with similar estimated effect sizes. These components gave CPOP the ability to have a stable performance across datasets of similar biology, minimising the effect of technical noise often generated by omics platforms. We present a comprehensive evaluation using melanoma transcriptomics data to demonstrate its potential to be used as a critical part of a clinical screening framework for precision medicine. Additional assessment of generalisation was demonstrated with ovarian cancer and inflammatory bowel disease studies.
Beim Winterbaden führen repetitive Kaltreize zur Bildung von Antioxidantien und zur Immunstärkung
Authors: Siems Werner , Brenke Rainer 
Published: July 2022

SummaryBaden und Wasseranwendungen haben für den Menschen seit langer Zeit kulturelle und gesundheitliche Bedeutung. Dabei spielen Kältereize wie bei der Kneipp-Therapie oder das Winterbaden eine besondere Rolle für die Durchblutung, die Immunabwehr, aber auch speziell zur Bildung von Antioxidantien.
Kosten-Effektivitäts-Analyse des Optifast 52 Programms bei
Patienten mit Adipositas Grad III und Diabetes mellitus Typ 2
Authors: Thiem Helena , Rychlik Reinhard P.T. , Weimann Arved 
Published: July 2022

Zusammenfassung
Hintergrund Adipositas stellt für eine Vielzahl weiterer
Erkrankungen einen wesentlichen Risikofaktor dar, darunter insbesondere Diabetes
mellitus Typ 2 (DMT2). DMT2 als Adipositas-assoziierte Folgeerkrankung bedeutet
sowohl aus medizinischer als auch ökonomischer Sicht eine hohe Belastung
für das deutsche Gesundheitssystem. Ziel therapeutischer
Maßnahmen zur Gewichtsreduktion bei Patienten mit DMT2 ist somit immer
auch die Verbesserung der diabetischen Stoffwechsellage. Bei Patienten mit
Adipositas Grad III (BMI≥40 kg/m2) kann
alternativ zu einer metabolischen bariatrischen Operation auch ein
strukturiertes, multimodales Therapieprogramm (Optifast 52 Programm) angeboten
werden.
Methodik In einer Kosten-Effektivitäts-Analyse sollen die
gesundheitsökonomischen Auswirkungen des Optifast 52 Programms im
Vergleich zur metabolischen Operation bei adipösen Patienten (BMI
40-50 kg/m2) mit DMT2 als Adipositas-assoziierter
Begleiterkrankung ermittelt werden. Ziel beider Therapieoptionen ist die
Remission des DMT2 aufgrund von Gewichtsreduktion. Mithilfe eines
Entscheidungsbaum-Modells wird die Therapie des DMT2 für einen Zeitraum
von drei Jahren modelliert. Berücksichtigt werden die direkten
medizinischen Kosten aus Perspektive der gesetzlichen Krankenversicherung in
Deutschland.
Ergebnisse Die kumulierten Behandlungskosten des DMT2 liegen unter
Anwendung des Optifast 52 Programms bei durchschnittlich 9.425,01 Euro
für den Gesamtzeitraum von drei Jahren im Vergleich zu 13.727,94 Euro
für Patienten mit metabolischer Operation. Unter
Berücksichtigung der Effektivität der beiden Therapieoptionen
zeigt sich, dass das Optifast 52 Programm mit 11.536,33 Euro im Vergleich zu
14.908,56 Euro für eine metabolische Operation kosteneffektiv ist.
Schlussfolgerung Die Reduktion des Körpergewichts ist bei
Patienten mit Adipositas wesentlich für eine erfolgreiche Therapie des
DMT2. Die metabolische Operation kann dabei zu deutlichen Gewichtsverlusten
führen, ist jedoch aufgrund der vergleichsweise höheren
Komplikationsraten und der hohen finanziellen Belastung für das deutsche
Gesundheitssystem kritisch zu sehen. Aus gesundheitsökonomischer Sicht
stellt das Optifast 52 Programm deswegen eine kosteneffektive Alternative zur
metabolischen Operation dar.
In Vitro Evaluation of Cytotoxicity and Anticancer Activity of Herbal Extract V2S2 (Coded Drug) on Human Cancer Cell Lines
Authors: Charak Sandeep , Sharma Monika , Porte Sharad M. 
Published: July 2022

Abstract
Background Cancer is the leading cause of morbidity and mortality worldwide. It encompasses a large family of diseases exhibiting abnormal cell growth with the potential to invade or spread to other part of the body. Natural extracts have been used as an efficient anticancer agent that show promising results. In this, study the cytotoxicity and anticancer effect of Ayurvedic herbal extract code name V2S2 was studied and compared with control drug Adriamycin that is an established chemotherapeutic drug.
Materials and Methods Ayurvedic coded drug V2S2 is a hydroalcoholic extract of herbs. The in vitro anticancer study was performed with sulforhodamine B assay in TATA Memorial, ACTREC Mumbai as per National Cancer Institute guidelines.
Result GI50 of V2S2 study drug and Adriamycin on COLO-205, HOP-62, K-562, ISHIKAWA, HeLa, MCF-7, SCC-40, Hep-G2 and MIA-PA-CA-2 is less than 10 that means both drugs have equal anticancer activity.
Conclusion The study group has more and less equal potential of anticancer activity in compared with a transient's standard anticancer drug. Moreover, in vitro monkey kidney normal cell line study drug V2S2 shows same cytotoxicity as shown by control drug Adriamycin.
Photon-Counting Detectors in Computed Tomography: A Review
Authors: Gomes Muriel Jeremia , Jaseemudheen Manakkal M. 
Published: July 2022

AbstractPhoton-counting computed tomography (CT) is a new technique that has the potential to revolutionize clinical CT and is predicted to be the next significant advancement. In recent years, tremendous research has been conducted to demonstrate the developments in hardware assembly and its working principles. The articles in this review were obtained by conducting a search of the MEDLINE database. Photon-counting detectors (PCDs) provide excellent quality diagnostic images with high spatial resolution, reduced noise, artifacts, increased contrast-to-noise ratio, and multienergy data acquisition as compared with conventionally used energy-integrating detector (EID). The search covered articles published between 2011 and 2021. The title and abstract of each article were reviewed as determined by the search strategy. From these, eligible studies and articles that provided the working and clinical application of PCDs were selected. This article aims to provide a systematic review of the basic working principles of PCDs, emphasize the uses and clinical applications of PCDs, and compare it to EIDs. It provides a nonmathematical explanation and understanding of photon-counting CT systems for radiologists as well as clinicians.
ST-Segment Elevation Myocardial Infarction and Right Atrial Myxoma
Authors: Vondran Maximilian , Ghazy Tamer , Andrási Terézia Bogdana , Rastan Ardawan Julian 
Published: July 2022

Abstract
Background Cardiac myxoma is the most common primary cardiac tumor. Although benign, it can cause life-threatening complications due to embolization.
Case Presentation We describe an ST-elevation myocardial infarction (STEMI) involving a giant right atrial myxoma and persisting foramen ovale (PFO) in a 64-year-old male patient and report on emergency percutaneous interventional therapy and subsequent cardiac surgery to remove the right atrial myxoma.
Conclusion A right atrial myxoma, combined with a PFO, can cause a STEMI. Therefore, every acute coronary syndrome patient should undergo ultrafast exploratory emergency echocardiography to protect the physician from unpleasant surprises.
Vertical Skeletal Changes after Extraction and Nonextraction Orthodontic Treatment
Authors: Shafique Hafiza Z. , Zaheer Rumeesha , Jan Abdullah , Mughal Alaina T. , Shahid Rooma , Ghaffar Fareena , Zahoor Tooba , Mehmood Sundas , Nawaz Ramsha , Umar Safia , Hassan Mehak , Mudasser Muhammad A. 
Published: July 2022

Abstract
Objectives Due to the constant battle regarding the controversial topic of orthodontic extraction, this study aims to assess the changes in vertical dimensions of patients treated with premolar extractions compared with nonextraction orthodontic patients.
Materials and Methods A sample of 60 borderline patients were recruited and divided into extraction and nonextraction groups. Eleven pretreatment cephalometric measurements were recorded using WebCeph and patients were followed-up until the completion of treatment.
Statistical Analysis Intragroup and intergroup comparisons were made using paired t-test and two-sample independent t-test, respectively. The joint significance of differences was measured using F-tests.
Results The intragroup comparison revealed that in the extraction group, the vertical dimension was significantly increased posttreatment for four cephalometric measurements, that is, mandibular plane angle (p < 0.05), palatal plane angle (p < 0.05), Frankfort mandibular plane angle (p < 0.05), and y-axis (p < 0.05). In the comparison of the posttreatment values of both groups, the mean differences of the posttreatment values for sella nasion (SN)-gonion (Go)-gnathion (Gn) angle (p = 0.008), the total anterior (p = 0.050), and lower anterior facial heights (AFH; p = 0.011) were significantly higher. At the same time, the Jarabak ratio was significantly (p = 0.006) lower in the extraction group than in the nonextraction group.
Conclusion The increase in vertical dimension is significantly higher in the extraction group than in the nonextraction group which indicates a significant impact of orthodontic extraction on the vertical dimensions.
Effect of Oxygen and Water on the Stability of Imipenem and Cilastatin Sodium for Injection
Authors: Zhang Meng , Liu Chun-Feng , Chen Xiao-Yan , Yang Li-Na , Zhu Chun-Mei , Teng Jian-Hao , Wu Hao-Xiang , Zhang Fu-Li 
Published: July 2022

AbstractThe study aimed to investigate the factors affecting the stability of imipenem and cilastatin sodium for injection (IMI/CIL) to improve the quality and stability in IMI/CIL preparation. In this study, the effects of headspace oxygen (HO), water content, particle shape, and particle size on the stability of IMI/CIL were investigated. IMI/CIL was purged with air, premixed oxygen/nitrogen gas (5%/95%), or high-purity nitrogen (99.999%) at 20, 5, or 2% oxygen levels to prepare IMI/CIL with different HO levels. IMI/CIL was stored at 30, 45, and 75% relative humidity for 30 days to prepare IMI/CIL with different water contents. High-performance liquid chromatography method was used for analysis. The results showed that oxygen, water, particle shape, and particle size had significant effects on the stability of IMI/CIL, and free water content is a better predictor of the safety and stability of imipenem and cilastatin sodium than the total water content. The optimization scheme of the above parameters is proposed, which significantly improves the stability of IMI/CIL. This study led to a better understanding of the degradation mechanism of imipenem and cilastatin sodium, and could provide a reference for the selection and control of IMI/CIL process conditions. This study would contribute to the development of IMI/CIL with improved stability.
Acute Liver Injury due to Glecaprevir/Pibrentasvir in a Patient with Chronic Hepatitis C Virus Infection without Cirrhosis
Authors: Jain Ayushi , Mumtaz Khalid 
Published: July 2022

AbstractWe reported a rare case of acute liver injury in a patient with chronic hepatitis C virus infection without cirrhosis 4 weeks after initiation of glecaprevir/pibrentasvir. After prompt cessation of antiviral therapy, liver enzymes rapidly improved toward baseline. This case reflects the need to remain vigilant for the development of acute liver injury after initiation of glecaprevir/pibrentasvir even without a diagnosis of cirrhosis.
The Effect of Probiotic Lactobacillus acidophilus and Ethanolic Propolis Compound toward Nucleic Acid Deposition in the Extracellular Polymeric Substance of Root Canal Bacteria
Authors: Adiningrat Arya , Kusnadi Rifkhi A. , Allam Asyam S. , Sofiani Erma , Maulana Ikhsan , Yumoto Hiromichi 
Published: July 2022

Abstract
Objective This study aimed to evaluate the effects of Apis trigona ethanolic propolis and probiotic bacteria Lactobacillus acidophilus on the nucleic acid concentration in the extracellular polymeric substances (EPS) derived from biofilm of root canal bacteria.
Materials and Methods Clinical bacteria of the root canal were cultured with ethanolic extract of propolis (EEP; 10 or 0.1%) and L. acidophilus. After the formation of biofilm was observed in the monolayer bacterial culture under several conditions, the enzymatic treatment and nucleic acid quantification were sequentially performed.
Statistical Analysis Independent t-test and Mann–Whitney were performed following data normality to analyze the significant differences of the treatment effect on the nucleic acid concentration in EPS from the isolated biofilm.
Results The results showed that the nucleic acid concentration in EPS biofilm were not increased by coculture with L. acidophilus as probiotics. However, the treatment with 10% EEP could significantly increase nucleic acid concentration.
Conclusion This study suggested that the biosurfactants from probiotic bacteria L. acidophilus might be a promising candidate for endodontic treatment, arguably better than EEP in inhibiting biofilm maturation and complexity.