bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online self-disclosure and well-being among Vietnamese adolescents: online social support as a mediator
Authors: Nguyen Hung Thanh , Ho Thi Truc Quynh 
Published: May 2022

Purpose
Online self-disclosure and online social support have important effects on well-being. The purpose of this study was to examine the indirect effect of online social support through social networking sites (SNSs) in the link between online self-disclosure through SNSs and well-being among Vietnamese adolescents.

Design/methodology/approach
Using a convenience sample of 980 Vietnamese adolescents (332 men, 648 women) and three scales (the Subjective Happiness Scale, the Self-Disclosure Scale and the Two-Way Social Support Scale), this study investigated whether online self-disclosure has a direct and indirect effects on well-being when mediated by online social support.

Findings
Mediation analysis showed that online social support partially mediated the link between online self-disclosure and well-being among Vietnamese adolescents, β = 0.008, standard error = 0.004, confidence interval = [0.001, 0.017].

Originality/value
This study provides an important practical basis for developing interventions to improve the well-being of adolescents who use SNSs. This finding indicated that adolescents’ well-being can be enhanced through online self-disclosure and online social support.
Impact of the pandemic on social media influencer marketing in fashion: a qualitative study
Authors: Le Kent , Aydin Gokhan 
Published: May 2022

Purpose
In spite of the rise of social media influencers observed in the 2010s, the direction and future of influencers are ambiguous. This popular yet overused marketing tool has shown certain problems and limitations such as a decrease in perceived authenticity and market saturation. Additionally, the outbreak of COVD-19 has amplified the significance of these factors and made many companies and influencers reconsider their involvement in influencer marketing. Within this context, this paper aims to explore whether influencers were impacted by diminishing perceived authenticity, market saturation or the prolonged pandemic. Also, the authors aim to investigate influencers’ perception of the future of influencer marketing post-pandemic.

Design/methodology/approach
To gain insight into trends in influencer marketing from the influencer’s perspective, this paper uses qualitative research in the form of interviews with influencers and industry professionals.

Findings
The findings highlight the importance of perceived authenticity for success in influencer marketing. Most interviewees indicated that they had noticed a boom in social media influencer marketing before the pandemic, yet provided mixed views regarding the market during the pandemic. Several believe that influencers will continue to be relevant in the increasingly digital world (e.g. increasing digital marketing spend and e-commerce), whereas an expectation of new digital platforms and innovations was also observed. In the long term, saturation and decreased effectiveness were predicted by several interviewees.

Originality/value
This under-researched topic is of relevance especially to consumer goods companies, as social media marketing and influencer marketing are currently highly effective and popular tools. To refine marketing strategies designed around influencers, understanding the limitations, in the context of COVID-19, is crucial.
Will legalizing corporate social responsibility get businesses to participate in welfare activities – the case of India
Authors: Narayanan Sajith , Singh Guru Ashish 
Published: May 2022

Purpose
The purpose of this study is to investigate the role and impact of state regulation of corporate social responsibility (CSR) spending on company actions and to examine whether making mandatory CSR encourages businesses to engage in social welfare projects. Additionally, the authors also investigate whether these CSR expenditures can enable India to meet the Sustainable Development Goals (SDGs) 2030.

Design/methodology/approach
CSR expenditure data from the government repository of 22,531 eligible companies in India were studied from FY2014–2015 to FY2019–2020. CSR spending is further classified according to development areas of Schedule VII of the Companies Act, 2013, and mapped with the SDGs to see which ones the corporations have prioritized.

Findings
CSR spending increased from INR 10,066 crore in 2014–2015 to INR 24,689 crore in 2019–2020. Companies have prioritized CSR expenditure on education, followed by health care and rural development. The number of companies spending more than the mandated expenditure increased by around 75% from 2014–2015 to 2019–2020. However, the “comply or explain” approach of the law has led to a major number of companies spending zero on CSR. Companies have generally concentrated on moving CSR funds to designated funds rather than using them for capacity development to instill social responsibility culture.

Originality/value
This study provides evidence of the impact of mandatory CSR expenditure on welfare activities and SDGs. Unlike previous research, the results of this study are based on CSR expenditures rather than voluntary CSR scores.
High‐pressure processing treatment of beef burgers: Effect on Escherichia coli O157 inactivation evaluated by plate count and PMA‐qPCR
Authors: Rey María de los Ángeles , Rodriguez Racca Anabel , Rossi Ribeiro Luma , Dos Santos Cruz Fabiano , Cap Mariana , Mozgovoj Marina Valeria , Cristianini Marcelo , Vaudagna Sergio Ramón 
Published: May 2022

AbstractPropidium monoazide coupled to real time PCR (PMA‐qPCR) is a novel methodology proposed for the quantification of viable bacteria in food after microbial inactivation treatments. The aim of this work was to assess the effectiveness of different pressure levels on the lethality of a pool of Escherichia coli O157 strains in beef burgers by plate count and PMA‐qPCR using uidA as target gene. Also, the effect on native microbiota counts, E. coli O157 counts, and physiochemical parameters of beef burgers during storage in refrigeration and frozen conditions were assessed. The treatment at 600 MPa for 5 min was the most lethal and was selected for the evaluation of bacteria behavior under storage conditions. Native microbiota and E. coli O157 were not recovered during refrigerated and frozen storage (4°C for 7 days and −18°C for 35 days). Cooking weight loss, pH, chromatic parameters, and texture were affected by HPP.Practical ApplicationPractical Application: PMA‐qPCR can be used as an alternative to assess microbial inactivation by different high pressure processing (HPP) conditions (pressure level, holding time and temperature) more rapidly than conventional plate counts. In addition, it has the benefit of being able to quantify viable but nonculturable bacteria from contaminated beef burgers after HPP. Moreover, this novel technique generates less pathogenic residues, which minimizes workers' exposure to human biohazards.
A road map for in vivo evolution experiments with blood‐borne parasitic microbes
Authors: Rodríguez‐Pastor Ruth , Shafran Yarden , Knossow Nadav , Gutiérrez Ricardo , Harrus Shimon , Zaman Luis , Lenski Richard E. , Barrick Jeffrey E. , Hawlena Hadas 
Published: May 2022

AbstractLaboratory experiments in which blood‐borne parasitic microbes evolve in their animal hosts offer an opportunity to study parasite evolution and adaptation in real time and under natural settings. The main challenge of these experiments is to establish a protocol that is both practical over multiple passages and accurately reflects natural transmission scenarios and mechanisms. We provide a guide to the steps that should be considered when designing such a protocol, and we demonstrate its use via a case study. We highlight the importance of choosing suitable ancestral genotypes, treatments, number of replicates per treatment, types of negative controls, dependent variables, covariates, and the timing of checkpoints for the experimental design. We also recommend specific preliminary experiments to determine effective methods for parasite quantification, transmission, and preservation. Although these methodological considerations are technical, they also often have conceptual implications. To this end, we encourage other researchers to design and conduct in vivo evolution experiments with blood‐borne parasitic microbes, despite the challenges that the work entails.
Geochemistry and Mineralogy of Paleocene Coal from the Padhrar and Darra Adam Khel Coalfields of Pakistan
Authors: UMAIR Muhammad , YANG Ruidong , CHENG Wei , KHATTAK Salman Ahmed 
Published: May 2022

AbstractPakistan is rich in coal resources, which amount to around 186 billion tons. The Paleocene Padhrar and Darra Adam Khel coalfields are located in the Central Salt Range Punjab Province and the Khyber Pakhtunkhwa Province, Pakistan, respectively. Padhrar coal has not been studied in detail and the Darra Adam Khel coalfields are newly‐discovered, so no research has been done, due to security considerations. In this study, an attempt has been made to study the geochemical and mineralogical characteristics of the Padhrar and Darra Adam Khel coals, in order to learn about the coal quality, element enrichment mechanism, sedimentary medium conditions and potentially valuable elements for coal utilization. The Padhrar and Darra Adam Khel coals are low to medium ash, low moisture content, high in volatiles and high total sulfur coal. The vitrinite reflectance in Darra Adam Khel coal is higher than in Padhrar coal, indicating either a greater burial depth or the effects of Himalayan tectonism. The vitrinite content is dominant in the Padhrar and Darra Adam Khel coals, followed by inertinite and liptinite, the major minerals including quartz, clay minerals, calcite and pyrite. The trace elements Ni, As, Be Zn, Ge, Mo, Ta, W, Co and Nb, Sn, Hf, Ta, Pb, Th, Cd, In, Be, V, Cr, Zr, Ag, Li, W and Co are concentrated in some of the Padhrar and Darra Adam Khel coal samples, respectively. The Padhrar coal shows positive Ce, Eu and Gd anomalies, with most of the Darra Adam Khel coal showing negative Ce, Eu and positive Gd anomalies with high LREE. The Al2O3/TiO2 values indicate that the sediment source of the Padhrar and Darra Adam Khel coals is mostly related to intermediate igneous rocks. The Sr/Ba, SiO2 + Al2O3, Fe2O3 + CaO + MgO/SiO2 + Al2O3 and high sulfur content in the Padhrar and Darra Adam Khel coals indicate epithermal and marine water influence with a tidal flat, coal‐forming environment and a deltaic coal‐forming environment, respectively.
Galectin‐3 enhances trastuzumab resistance by regulating cancer malignancy and stemness in HER2‐positive breast cancer cells
Authors: Chen Yuqiu , Xu Jiawei , Pan Wang , Xu Xiaofan , Ma Xueping , Chu Ya'nan , Wang Lu , Pang Shuyun , Li Yujiao , Zou Bingjie , Zhou Guohua , Gu Jun 
Published: May 2022

AbstractPurposeThe aim of this study was to explore the role of galectin‐3 in human epidermal growth factor receptor 2 (HER2)‐positive breast cancer cells and the potential mechanism.MethodsKaplan–Meier (KM)‐plot and The Cancer Genome Atlas (TCGA) databases were used to study the role of galectin‐3 in the prognosis of HER2‐positive breast cancer. The effects of galectin‐3 on cell proliferation, migration, invasion, and colony formation ability in HER2‐positive breast cancer cells were examined. The relationship between galectin‐3 and important components in the HER2 pathways, including HER2, epidermal growth factor receptor (EGFR), protein kinase B (AKT), and phosphatase and tensin homolog (PTEN), was further studied. Lentivirus and CRISPR/Cas9 were used to construct stable cell lines. Cell counting kit‐8 (CCK‐8) and apoptosis assays were used to study the relationship between galectin‐3 and trastuzumab. The effect of galectin‐3 on cell stemness was studied by mammosphere formation assay. The effects of galectin‐3 on stemness biomarkers and the Notch1 pathway were examined. Tumorigenic models were used to evaluate the effects of galectin‐3 on tumorigenesis and the therapeutic effect of trastuzumab in vivo.ResultsHER2‐positive breast cancer patients with a high expression level of LGALS3 (the gene encoding galectin‐3) messenger RNA (mRNA) showed a poor prognosis. Galectin‐3 promoted cancer malignancy through phosphoinositide 3‐kinase (PI3K)/AKT signaling pathway activation and upregulated stemness by activating the Notch1 signaling pathway in HER2‐positive breast cancer cells. These two factors contributed to the enhancement of trastuzumab resistance in cells. Knockout of LGALS3 had a synergistic therapeutic effect with trastuzumab both in vitro and in vivo.ConclusionsGalectin‐3 may represent a prognostic predictor and therapeutic target for HER2‐positive breast cancer.
MiR‐200c‐3p and miR‐485‐5p overexpression elevates cisplatin sensitivity and suppresses the malignant phenotypes of non–small cell lung cancer cells through targeting RRM2
Authors: Liu Ying , Zhang Yong , Li Qiubo , Xu Ruiqi , Huang Nian 
Published: May 2022

AbstractBackgroundThis study intended to investigate the potential mechanism of microRNA‐200c‐3p (miR‐200c‐3p) and miR‐485‐5p in mediating the cisplatin (DDP) resistance in non–small cell lung cancer (NSCLC).MethodsQuantitative real‐time polymerase chain reaction (qRT‐PCR) was applied to measure the expression of miR‐200c‐3p, miR‐485‐5p, and ribonucleotide reductase regulatory subunit M2 (RRM2) messenger RNA (mRNA). 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay was used to analyze the DDP resistance and the proliferation of NSCLC cells. Colony formation assay was used to assess cell proliferation. Transwell assays were used to evaluate cell migration and invasion. The target relationship between RRM2 and miR‐200c‐3p or miR‐485‐5p was verified using dual‐luciferase reporter assay. The protein level of RRM2 was measured using Western blot assay. Animal experiments were conducted to analyze the roles of miR‐200c‐3p and miR‐485‐5p in the DDP resistance of xenograft tumors in vivo.ResultsMiR‐200c‐3p and miR‐485‐5p were both downregulated in DDP‐resistant NSCLC tissues and cell lines. Overexpressing miR‐200c‐3p or miR‐485‐5p suppressed the DDP resistance and malignant behaviors of NSCLC cells. MiR‐200c‐3p played a synergistic role with miR‐485‐5p in regulating the chemo‐resistance and biological behaviors NSCLC cells. RRM2 was confirmed as a target of miR‐200c‐3p and miR‐485‐5p. RRM2 silencing restrained the DDP resistance and progression of NSCLC. RRM2 overexpression partly reversed miR‐200c‐3p or miR‐485‐5p‐induced influences in NSCLC cells. The overexpression of miR‐200c‐3p or miR‐485‐5p aggravated DDP‐mediated suppressive effect on tumor growth in vivo.ConclusionMiR‐200c‐3p or miR‐485‐5p enhanced the DDP sensitivity and suppressed the malignant behaviors of NSCLC cells partly through targeting RRM2.
Age–period–cohort analysis of trends in tobacco smoking, cannabis use, and their co‐use in the Australian population
Authors: Leung Janni , Gravely Shannon , Lim Carmen , Hall Wayne , Chan Gary 
Published: May 2022

AbstractBackground and aimThe prevalence of tobacco smoking has declined in most high‐income countries, while cannabis use has been rising. Moreover, cannabis use has been found to have increased among cigarette smokers in recent years in jurisdictions where it has been either decriminalized or legalized. This study measured trends in cannabis, tobacco and the co‐use of cannabis and tobacco in Australia.DesignAge–period–cohort analysis.Setting and participantsParticipants were n = 143 344 individuals aged 18–80 years who participated in Australia's National Drug Strategy Household Surveys (NDSHS) between 2001 and 2019.MeasurementsRegular (weekly/more frequently): (1) tobacco smoking only, (2) cannabis use only and (3) the co‐use of cannabis and tobacco.FindingsPrevalence of only smoking tobacco decreased in all age groups (P < 0.001) and birth cohorts between 2001 and 2019, but the co‐use of cannabis and tobacco did not. Younger cohorts were much less likely to co‐use tobacco and cannabis (P = 0.02). Period trends showed that both cannabis use only and the co‐use of cannabis and tobacco have increased since 2013.ConclusionThere has been a consistent decrease in exclusive tobacco smoking across age, period and birth cohorts between 2001 and 2019 in Australia, although there is a recent increasing period trend in cannabis use with or without tobacco. The non‐decreasing trend of co‐use may reflect the strong tobacco control policies introduced over the period and changing attitudes towards cannabis use in Australia.
Towards optimum smoking cessation interventions during pregnancy: a household model to explore cost‐effectiveness
Authors: Saygın Avşar Tuba , Jackson Louise , Barton Pelham , Jones Matthew , McLeod Hugh 
Published: May 2022

AbstractBackground and AimsPrevious economic evaluations of smoking cessation interventions for pregnant women are limited to single components, which do not in isolation offer sufficient potential impact to address smoking cessation targets. To inform the development of more appropriate complex interventions, we (1) describe the development of the Economics of Smoking in Pregnancy: Household (ESIP.H) model for estimating the life‐time cost‐effectiveness of smoking cessation interventions aimed at pregnant women and (2) use a hypothetical case study to demonstrate how ESIP.H can be used to identify the characteristics of optimum smoking cessation interventions.MethodsThe hypothetical intervention was based on current evidence relating to component elements, including financial incentives, partner smoking, intensive behaviour change support, cigarettes consumption and duration of support to 12 months post‐partum. ESIP.H was developed to assess the life‐time health and cost impacts of multi‐component interventions compared with standard National Health Service (NHS) care in England. ESIP.H considers cigarette consumption, partner smoking and some health conditions (e.g. obesity) that were not included in previous models. The Markov model's parameters were estimated based on published literature, expert judgement and evidence‐based assumptions. The hypothetical intervention was evaluated from an NHS perspective.ResultsThe hypothetical intervention was associated with an incremental gain in quitters (mother and partner) at 12 months postpartum of 249 [95% confidence interval (CI) = 195–304] per 1000 pregnant smokers. Over the long‐term, it had an incremental negative cost of £193 (CI = –£779 to 344) and it improved health, with a 0.50 (CI = 0.36–0.69) increase in quality‐adjusted life years (QALYs) for mothers, partners and offspring, with a 100% probability of being cost‐effective.ConclusionsThe Economics of Smoking in Pregnancy: Household model for estimating cost‐effectiveness of smoking cessation interventions aimed at pregnant women found that a hypothetical smoking cessation intervention would greatly extend reach, reduce smoking and be cost‐effective.
Indonesian consensus on systemic therapies for hepatocellular carcinoma
Authors: Hasan Irsan , Loho Imelda Maria , Setiawan Poernomo Boedi , Djumhana Ali , Purnomo Hery Djagat , Siregar Lianda , Gani Rino Alvani , Sulaiman Andri Sanityoso , Lesmana Cosmas Rinaldi Adithya 
Published: May 2022

AbstractHepatocellular carcinoma (HCC) is a deadly cancer with a rising incidence in the last 20 years. Most patients are diagnosed late when curative treatment is no longer feasible. With the background of chronic liver disease in most patients, the management of HCC becomes more complicated, in which well‐preserved liver function is a prerequisite for locoregional or systemic therapies. In 2008, sorafenib became the first systemic agent proven to provide survival benefit for patients with advanced‐stage HCC. For nearly a decade, no treatment has succeeded in providing better results than sorafenib. However, numerous advances in systemic therapies have emerged in the last 5 years to fulfill the unmet needs of effective therapeutic options. Several agents have been approved for clinical use after positive results in phase III clinical trials, including lenvatinib, regorafenib, cabozantinib, ramucirumab, and lastly immune checkpoint inhibitor atezolizumab in combination with bevacizumab, a monoclonal antibody targeting the vascular endothelial growth factor. With various options available, knowledge on the clinical evidence of each drug, their safety profile, as well as the patient characteristics and preferences become mandatory in clinical decision making. The objective of this consensus is to help clinicians, health‐care workers, and policy makers in providing best clinical care for HCC patients.
Large variation in radiation therapy fractionation for multiple myeloma in Australia
Authors: Ong Wee Loon , MacManus Michael , Milne Roger L. , Foroudi Farshad , Millar Jeremy L. 
Published: May 2022

AbstractAimTo evaluate the patterns of use of different radiation therapy (RT) fractionation for multiple myeloma (MM) bone disease.MethodsThis is a population‐based cohort of patients with MM who had RT between 2012 and 2017 as captured in the statewide Victorian Radiotherapy Minimum Data Set in Australia. Data linkage was performed to identify subsets of RT delivered within 3 months of death. RT fractionation was classified into four groups: single‐fraction (SFRT), 2–5, 6–10, and > 10 fractions. Changes in RT fractionation use over time were evaluated with the Cochran–Armitage test for trend. Factors associated with RT fractionation were evaluated using multivariate logistic regressions.ResultsNine hundred and sixty‐seven courses of RT were delivered in 623 patients. The proportion of SFRT, 2–5, 6–10 and > 10 fractions RT was 18%, 47%, 28%, and 7%, respectively. There was an increase in the use of 2–5 fractions, from 48% in 2012 to 60% in 2017 (p‐trend < .001), with corresponding decrease in the use of 6–10 fractions, from 26% in 2012 to 20% in 2017 (p‐trend = .003). Nine percent (40/430) of RT courses at private institutions were SFRT, compared to 25% (135/537) in public institutions (p < .001). In multivariate analyses, treatment in private institution was the strongest predictor of multifraction RT use. SFRT use was more common closer to the end of life–18%, 14%, and 33% of RT within 2–3, 1–2, < 1 month of death, respectively.ConclusionThere is increasing use of shorter course RT (2–5 fractions) for MM over time. SFRT use remains low, with large variation in practice.
The role of hypoxia in the pathophysiology of chronic rhinosinusitis
Authors: Zhong Bing , Seah Jun Jie , Liu Feng , Ba Luo , Du Jintao , Wang De Yun 
Published: May 2022

AbstractChronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nasal cavity characterized by excessive nasal mucus secretion and nasal congestion. The development of CRS is related to pathological mechanisms induced by hypoxia. Under hypoxic conditions, the stable expression of both Hypoxia inducible factor‐1 (HIF‐1) α and HIF‐2α are involved in the immune response and inflammatory pathways of CRS. The imbalance in the composition of nasal microbiota may affect the hypoxic state of CRS and perpetuate existing inflammation. Hypoxia affects the differentiation of nasal epithelial cells such as ciliated cells and goblet cells, induces fibroblast proliferation, and leads to epithelial‐mesenchymal transition (EMT) and tissue remodeling. Hypoxia also affects the proliferation and differentiation of macrophages, eosinophils, basophils, and mast cells in sinonasal mucosa, and thus influences the inflammatory state of CRS by regulating T cells and B cells. Given the multifactorial nature in which HIF is linked to CRS, this study aims to elucidate the effect of hypoxia on the pathogenic mechanisms of CRS.