bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal mental health in the first year postpartum in a large Irish population cohort: the MAMMI study
Authors: Hannon Susan , Gartland Deirdre , Higgins Agnes , Brown Stephanie J. , Carroll Margaret , Begley Cecily , Daly Déirdre 
Published: April 2022

Abstract

Purpose
The international perinatal literature focuses on depression in the postpartum period. Prevalence and pathways of depression, anxiety and stress from pregnancy through the first postpartum year are seldom investigated.

Methods
MAMMI is a prospective cohort study of 3009 first-time mothers recruited in pregnancy. Depressive, anxiety and stress symptoms measured using the Depression, Anxiety and Stress Scale (DASS 21) in pregnancy and at 3-, 6-, 9- and/or 12-months postpartum.

Results
Prevalence of depressive and stress symptoms was lowest in pregnancy, increasing to 12-months postpartum. Anxiety symptoms remained relatively stable over time. In the first year after having their first baby, one in ten women reported moderate/severe anxiety symptoms (9.5%), 14.2% reported depression symptoms, and one in five stress symptoms (19.2%). Sociodemographic factors associated with increased odds of postpartum depression, anxiety and stress symptoms were younger age and being born in a non-EU country; socioeconomic factors were not living with a partner, not having postgraduate education and being unemployed during pregnancy. Retrospective reporting of poor mental health in the year prior to pregnancy and symptoms during pregnancy were strongly associated with poor postpartum mental health.

Conclusions
The current findings suggest that the current model of 6-week postpartum care in Ireland is insufficient to detect and provide adequate support for women’s mental health needs, with long-term implications for women and children.
Identifikation von Stoffeinträgen aus dem Alterzbergbau in die Freiberger Mulde
Authors: Reumann Gesche , Grundmann Jens , Burghardt Diana , Hauffe Corina , Stevens Christine , Jahns Christin 
Published: April 2022

ZusammenfassungDie Freiberger Mulde, die einen Teil des Freiberger Reviers entwässert, weist hohe Schwermetall‑, Arsen- und Sulfatbelastungen auf. Besonders der Abschnitt zwischen Berthelsdorf und Siebenlehn ist stark durch den Alterzbergbau sowie die Bunt- und Edelmetallurgie geprägt. Das Ziel von zwei Messkampagnen war die Identifikation aller punktueller Einleiter in diesem Abschnitt, um mittels einer Frachtbilanzierung die wesentlichen punktuellen Einleiter sowie mögliche diffuse Zutritte von Arsen, Blei, Cadmium, Kupfer, Eisen, Nickel, Nitrat, Sulfat und Zink zu identifizieren. Hierbei wurden acht punktuelle Einleiter identifiziert, die maßgeblich für eine entsprechende Frachtzunahme im Untersuchungsgebiet verantwortlich sind. Die Aufstellung der Frachtbilanzen erfolgte nach einem vereinfachten Ansatz, der Rückschlüsse auf mögliche diffuse Zutritte oder Verluste durch z. B. Rückhalt, Abbau und Versickerung erlaubt. Dabei zeigte eine Bilanzierung über das gesamte Untersuchungsgebiet nur eine geringe Aussagekraft. Erst durch eine abschnittsweise Bilanzierung entlang des Untersuchungsgebietes wird ersichtlich, dass sich Eintrags- und Rückhalteprozesse abwechseln und möglicherweise innerhalb der Abschnitte überlagern. Dies liefert nützliche Erkenntnisse für weitere Betrachtungen der Belastungsursachen und die Umsetzung der Wasserrahmenrichtlinie im Einzugsgebiet der Freiberger Mulde.
RAB GTPases and SNAREs at the trans-Golgi network in plants
Authors: Ito Emi , Uemura Tomohiro 
Published: April 2022

AbstractMembrane traffic is a fundamental cellular system to exchange proteins and membrane lipids among single membrane-bound organelles or between an organelle and the plasma membrane in order to keep integrity of the endomembrane system. RAB GTPases and SNARE proteins, the key regulators of membrane traffic, are conserved broadly among eukaryotic species. However, genome-wide analyses showed that organization of RABs and SNAREs that regulate the post-Golgi transport pathways is greatly diversified in plants compared to other model eukaryotes. Furthermore, some organelles acquired unique properties in plant lineages. Like in other eukaryotic systems, the trans-Golgi network of plants coordinates secretion and vacuolar transport; however, uniquely in plants, it also acts as a platform for endocytic transport and recycling. In this review, we focus on RAB GTPases and SNAREs that function at the TGN, and summarize how these regulators perform to control different transport pathways at the plant TGN. We also highlight the current knowledge of RABs and SNAREs’ role in regulation of plant development and plant responses to environmental stimuli.
Changing Metacognitive Appraisal Bias in High-Worriers Through Reappraisal Training
Authors: Ikani Nessa , Radix Anne K. , Rinck Mike , Becker Eni S. 
Published: April 2022

Abstract
Background and Objectives
Worry-related negative metacognitive beliefs about worrying maintain and predict pathological worry. For the current proof-of-principle study, we developed a computerized cognitive bias modification based—reappraisal training (RT), to modify the appraisal of negative metacognitive beliefs in a high-worrying sample. A functional and dysfunctional RT were pitted against each other to investigate whether appraisals of one’s thinking and coping changed following training. Moreover, training effects on the number of negative thoughts and interpretations of the worry content were examined.

Methods
Participants (N = 81) were trained to adopt a functional (disconfirmation of negative metacognitive beliefs) or dysfunctional (confirmation of negative metacognitive beliefs) appraisal style using a series of vignettes that had to be completed in line with the intended training direction. Changes in negative thoughts from pre- to post-RT were assessed with a behavioral state worry task, and transfer to interpretations with an open-ended stem sentence task.

Results
Findings support the use of the RT to alter a metacognitive appraisal bias, as participants receiving the functional RT reported fewer negative appraisals of one’s thinking and coping than participants in the dysfunctional RT group. Number of negative thoughts and interpretations were not directly affected by training.

Limitations
This study employed an analog sample and future research should replicate findings in a clinical sample for which negative metacognitions are more relevant.

Conclusions
These findings highlight the potential of metacognitive RT for future translational studies with (clinical) samples characterized by repetitive negative thinking and/or negative metacognitive beliefs.
Paraconsistent Belief Revision: An Algebraic Investigation
Authors: Carrara Massimiliano , Fazio Davide , Pra Baldi Michele 
Published: April 2022

AbstractThis paper offers a logico-algebraic investigation of AGM belief revision based on the logic of paradox ($$\mathrm {LP}$$
LP
). First, we define a concrete belief revision operator for $$\mathrm {LP}$$
LP
, proving that it satisfies a generalised version of the traditional AGM postulates. Moreover, we investigate to what extent the Levi and Harper identities, in their classical formulation, can be applied to a paraconsistent account of revision. We show that a generalised Levi-type identity still yields paraconsistent-based revisions that are fully compatible with the AGM postulates. The main outcome is that, once the classical AGM framework is lifted up to an appropriate level of generality, it still appears as a regulative ideal for treating of paraconsistent-based epistemic operators.
“No, Thanks”: How Do Requests for Feedback Affect the Consumption Behavior of Non-Compliers?
Authors: Perez Dikla , Oestreicher-Singer Gal , Zalmanson Lior , Rubin Matthew Matan 
Published: April 2022

Abstract
Consumers’ feedback helps firms, yet most requests for feedback are unanswered. Research on question–behavior effects suggests that providing feedback on prior experiences might influence subsequent consumption behavior, but provides little insight regarding users who decline requests (e.g., by clicking “No, Thanks”). Accordingly, we investigate whether the exposure to a request to rate a consumption experience influences users’ future conversion regardless of their compliance. We carried out two large-scale field studies in collaboration with a leading international website that offers basic service for free, and additional desirable features for a fee (“freemium”). We exposed users to a rating request and measured their subsequent likelihood of converting to the paid service. Users exposed to a rating request were more likely to convert compared with users who were not exposed; this effect persisted over 90 days. Notably, users who complied with the request were no more likely to convert compared with non-compliers.
A Novel Approach to Cross dataset studies in Facial Expression Recognition
Authors: Ramis Silvia , Buades Jose M. , Perales Francisco J. , Manresa-Yee Cristina 
Published: April 2022

AbstractRecognizing facial expressions is a challenging task both for computers and humans. Although recent deep learning-based approaches are achieving high accuracy results in this task, research in this area is mainly focused on improving results using a single dataset for training and testing. This approach lacks generality when applied to new images or when using it in in-the-wild contexts due to diversity in humans (e.g., age, ethnicity) and differences in capture conditions (e.g., lighting or background). The cross-datasets approach can overcome these limitations. In this work we present a method to combine multiple datasets and we conduct an exhaustive evaluation of a proposed system based on a CNN analyzing and comparing performance using single and cross-dataset approaches with other architectures. Results using the proposed system ranged from 31.56% to 61.78% when used in a single-dataset approach with different well-known datasets and improved up to 73.05% when using a cross-dataset approach. Finally, to study the system and humans’ performance in facial expressions classification, we compare the results of 253 participants with the system. Results show an 83.53% accuracy for humans and a correlation exists between the results obtained by the participants and the CNN.
Polymorphic distributivity
Authors: Bumford Dylan 
Published: April 2022

AbstractThis article describes a novel pattern of interpretations associated with universal determiners like ‘each’ and ‘every’. It is demonstrated that these canonically distributive quantifiers can give rise to surprising collective readings when they quantify into sub-clausal constituents, especially other Determiner Phrases. For instance, ‘two cards from each player’ can be understood to pick out a single assorted deck of cards, one whose contents co-vary with the players. Yet this deck as a whole may be said to participate in a range of collective activities (being shuffled together, being traded en masse, not fitting into a standard pack, etc.). Such examples are shown to differ from more familiar cumulative readings of the same quantifiers. A compositional analysis is offered that generalizes Krifka’s (2001) method of quantification into speech acts in order to accommodate quantification into a larger class of non-truth-denoting semantic objects, including in these cases, entities.
An engineering perspective on the numerics of quasi-periodic oscillations
Authors: Bäuerle Simon , Fiedler Robert , Hetzler Hartmut 
Published: April 2022

AbstractThe phenomenon of quasi-periodicity in deterministic dynamical systems describes stationary solutions, which neither exhibit a finite period length nor are chaotic. Recently, an increasing demand for robust numerical methods is driven by applied dynamics and industrial applications. In this context, direct time integration proves to be impractical due to extensive integration intervals. Therefore, in a first step, this contribution aims on giving an application oriented survey of the basic theory as well as alternative concepts. In the following, the focus is set on the direct computation of invariant manifolds (surfaces) on which quasi-periodic solutions evolve. This approach offers a unique framework from which classical methods (e.g., the multi-harmonic-balance) can be systematically deduced and mutual similarities between different methods may be revealed. This contribution starts with a brief summary of related mathematical basics, which is followed by an overview of available methods. Subsequently, the computation of invariant manifolds by means of solving a partial differential equation is emphasized. These PDEs may be formulated using different parametrization strategies. Here, the concept of hyper-time parametrization is particularly interesting, since it is a promising starting point for the development of numerical schemes with general applicability in engineering problems. In order to solve the underlying PDE, various methods may be used. The implementation of a Fourier-Galerkin method as well as a finite difference method is presented and compared on the basis of computational results of the van-der-Pol equation (with and without forcing). Moreover, it is demonstrated that both methods apply to periodic as well as quasi-periodic solutions alike. In order to exemplify the practical use, these methods are applied to a generic rotordynamic model problem.
COVID-19 and Civil Society in Southeast Asia: Beyond Shrinking Civic Space
Authors: Lorch Jasmin , Sombatpoonsiri Janjira 
Published: April 2022

AbstractIn this article we challenge the conventional wisdom that COVID-19 and related legal restrictions invariably reinforce a global trend of shrinking civic space. We argue that the legal guarantee (or restriction) of civil society rights is not the sole factor configuring civic space. Instead, we reconceptualize civic space by broadening its determinants to also include needs-induced space and civil society activism. Investigating five countries with flawed democracic or competitive autocracic regimes in Southeast Asia, we propose a three-pronged mechanism of how these determinants interact in the context of COVID-19. First, legal restrictions on civil society rights intertwine with the space created by health and economic needs to create new opportunities for civil society activism. Second, these new opportunity structures lead to the cross-fertilization between service delivery and advocacy activism by civil society. Third, this new trajectory of civil society activism works to sustain civic space.
FDG PET/CT and Dosimetric Studies of 177Lu-Lilotomab Satetraxetan in a First-in-Human Trial for Relapsed Indolent non-Hodgkin Lymphoma—Are We Hitting the Target?
Authors: Løndalen Ayca , Blakkisrud Johan , Revheim Mona-Elisabeth , Dahle Jostein , Kolstad Arne , Stokke Caroline 
Published: April 2022

Abstract

Purpose

[177Lu]Lu-lilotomab satetraxetan, a novel CD37 directed radioimmunotherapy (RIT), has been investigated in a first-in-human phase 1/2a study for relapsed indolent non-Hodgkin lymphoma. In this study, new methods were assessed to calculate the mean absorbed dose to the total tumor volume, with the aim of establishing potential dose–response relationships based on 2-deoxy-2-[18F]fluoro-d-glucose (FDG) positron emission tomography (PET) parameters and clinical response. Our second aim was to study if higher total tumor burden induces reduction in the 177Lu-lilotomab satetraxetan accumulation in tumor.

Procedures

Fifteen patients with different pre-dosing (non-radioactive lilotomab) regimens were included and the cohort was divided into low and high non-radioactive lilotomab pre-dosing groups for some of the analyses. 177Lu-lilotomab satetraxetan was administered at dosage levels of 10, 15, or 20 MBq/kg. Mean absorbed doses to the total tumor volume (tTAD) were calculated from posttreatment single-photon emission tomography (SPECT)/computed tomography (CT) acquisitions. Total values of metabolic tumor volume (tMTV), total lesion glycolysis (tTLG) and the percent change in these parameters were calculated from FDG PET/CT performed at baseline, and at 3 and 6 months after RIT. Clinical responses were evaluated at 6 months as complete remission (CR), partial remission (PR), stable disease (SD), or progressive disease (PD).

Results
Significant decreases in tMTV and tTLG were observed at 3 months for patients receiving tTAD ≥ 200 cGy compared to patients receiving tTAD < 200 cGy (p = .03 for both). All non-responders had tTAD < 200 cGy. Large variations in tTAD were observed in responders. Reduction in 177Lu-lilotomab satetraxetan uptake in tumor volume was not observed in patients with higher baseline tumor burden (tTMV).

Conclusion
tTAD of ≥ 200 cGy may prove valuable to ensure clinical response, but further studies are needed to confirm this in a larger patient population. Furthermore, this work indicates that higher baseline tumor burden (up to 585 cm3) did not induce reduction in radioimmunoconjugate accumulation in tumor.
Effects of sacubitril-valsartan on central and obstructive apneas in heart failure patients with reduced ejection fraction
Authors: Wang Youmeng , Branco Roberto Fernandes , Salanitro Matthew , Penzel Thomas , Schöbel Christoph 
Published: April 2022

Abstract
Objective
This study aimed to evaluate the effect of sacubitril-valsartan (SV) on central apneas (CA) and obstructive apneas (OA) in patients with heart failure with reduced ejection fraction (HFrEF).

Methods
In patients with HFrEF, SV initiation was titrated to the highest tolerable dosage. Patients were evaluated with portable apnea monitoring, echocardiography, and cardiopulmonary exercise testing at baseline and 3 months later.

Results
Of a total of 18 patients, 9 (50%) had OA, 7 (39%) had CA, and 2 (11%) had normal breathing. SV therapy was related to a reduction in NT-pro BNP and an improvement in LV function after 3 months. Portable apnea monitoring revealed a significant decrease of the respiratory event index (REI) after treatment with SV (20 ± 23 events/h to 7 ± 7 events/h, p = 0.003). When subgrouping according to type of apneas, REI, and time spent below 90% saturation (T90) decreased in patients with CA and OA (all p < 0.05).

Conclusion
In this prospective study, SV treatment for 3 months in patients with CA and OA is associated with a significant decrease in REI.
Observation of oxygen evolution over a {Ni12}-cluster-based metal-organic framework
Authors: Han Zongsu , Yan Zheng , Wang Kunyu , Kang Xinchen , Lv Kai , Zhang Xiaoping , Zhou Zhen , Yang Sihai , Shi Wei , Cheng Peng 
Published: April 2022

AbstractThe development of efficient electrocatalysts based on non-noble metals for oxygen evolution reaction (OER) remains an important and challenging task. Multinuclear transition-metal clusters with high structural stability are promising OER catalysts but their catalytic role is poorly understood. Here we report the crystallographic observation of OER activity over robust {Ni12}-clusters immobilised in a porous metal-organic framework, NKU-100, by single-crystal X-ray diffraction as a function of external applied potential. We observed the aggregation of confined oxygen species around the {Ni12}-cluster as a function of applied potential during the electrocatalytic process. The refined occupancy of these oxygen species shows a strong correlation with the variation of current density. This study demonstrates that the enrichment of oxygen species in the secondary co-ordination sphere of multinuclear transition-metal clusters can promote the OER activity.
Netzwerke, Plattformen und Ökosysteme: Organisationstheoretische Klärungen
Authors: Sydow Jörg , Auschra Carolin 
Published: April 2022

ZusammenfassungIm Zuge der zunehmenden Digitalisierung gewinnen interorganisationale Netzwerke, Plattformen und Ökosysteme zunehmend an Bedeutung. Jedoch bleibt oft unklar, was mit diesen Konzepten gemeint ist und in welchem Verhältnis sie zueinander stehen. Dieser Beitrag hat daher das Ziel, diese Konzepte genauer zu fassen und die jeweiligen Verhältnisse zueinander zu klären. Dies geschieht mithilfe der in der Organisationsforschung prominenten Praxis- und Institutionentheorie. Anhand der Dimensionen theoretische Wurzeln, zentrale Analyseebenen, Ziele, Governance/Steuerung, Dynamiken und Grenzen, Kooperation und Wettbewerb sowie Offenheit/Selektion von Mitgliedern werden die einzelnen Phänomene voneinander abgrenzt. Zudem werden die dyadischen und das triadische Verhältnis zueinander diskutiert und weitere Forschungsperspektiven aufgezeigt.
Evidence of a role for interleukin-6 in anoikis resistance in oral squamous cell carcinoma
Authors: Karavyraki Marilena , Porter Richard K. 
Published: April 2022

AbstractIn an endeavour to understand metastasis from oral squamous cell carcinomas, we characterised the metastatic potential of a human tongue derived cell line (SCC-4 cells) and compared this phenotype to pre-cancerous dysplastic oral keratinocyte (DOK) cells derived from human tongue and primary gingival keratinocytes (PGK). We demonstrate that SCC-4 cells constitutively synthesize and release significant amounts of IL-6, a process that is enhanced by the addition of the TLR2/TLR6 agonist, Pam2CSK4. The expression of TLR2/6 and IL-6Ra/gp130 receptors was also confirmed in SCC-4 cells. Cancerous SCC-4 human tongue cells also have a classic EMT profile, unlike precancerous human tongue DOK cells. We also established that IL-6 is drivinganoikisresistance in an autocrine fashion and that anti-IL-6 neutralising antibodies, anti-IL-6 receptor antibodies and anti-TLR2 receptor antibodies inhibitanoikisresistance in cancerous SCC-4 human tongue cells.The data suggest a promising role for anti-IL-6 receptor antibody and anti-TLR2 receptor antibody treatment for oral cancer.
No, water (still) doesn’t have a microstructural essence (reply to Hoefer & Martí)
Authors: Häggqvist Sören 
Published: April 2022

AbstractHäggqvist and Wikforss (2018) argued that in the case of so-called natural kind terms, semantic externalism relies on an untenable metaphysics of kinds: microessentialism. They further claimed that this metaphysics fails, for largely empirical reasons. Focussing on the case of water, Hoefer and Martí European Journal for the Philosophy of Science, 9, (2019) rejoin that suitably construed, microessentialism is correct. I argue that their defence of microessentialism fails.