bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of the ONCO-TreC electronic diary compared with a standard paper diary to improve adherence to oral cancer therapy in patients with solid and haematological tumours: protocol for a randomised controlled trial
Authors: Passardi Alessandro , Serra Patrizia , Caffo Orazio , Masini Carla , Brugugnoli Erika , Vespignani Roberto , Giardino Valeria , Petracci Elisabetta , Bartolini Giulia , Sullo Francesco , Anesi Cecilia , Dianti Marco , Eccher Claudio , Piras Enrico Maria , Gios Lorenzo , Campomori Annalisa , Oberosler Valentina , Forti Stefano 
Published: January 2022

IntroductionONCO-TreC platform consists of a mobile application delivered to patients as electronic diary and a web-based dashboard managed by healthcare professionals. We aim to compare the effectiveness of ONCO-TreC electronic diary with a standard paper diary, in improving adherence to oral cancer therapy in patients with solid and haematological tumours.Methods and analysisThis is an open label, superiority, randomised controlled trial conducted in two Italian oncology units. Patients will be randomised with a 1:1 ratio to electronic or paper diary. For both groups a counsellor will be responsible for drug and diary delivery. The evaluation period will end after six cycles of therapy. The primary aim is to compare the proportion of non-adherent patients in the two arms. Adherence will be measured through pill count; anyone who takes less than 90% of the total prescribed drug dose will be considered non-adherent. Assuming a percentage of non-adherent patients to oral therapy of 40% in arm B, and a 60% reduction in this percentage in arm A, a sample of 124 patients will provide 80% power to identify an absolute difference greater than 24 percentage points using a bilateral Fisher’s exact test with a significance level of 0.05. Considering a dropout rate of 10%, approximately 136 patients will have to be enrolled. The primary analysis will be performed on the intention-to-treat population. Secondary aims are to describe the reasons for non-adherence, the level of satisfaction of patients and healthcare professionals with the paper and electronic diary, and the impact of non-adherence in terms of healthcare costs.Ethics and disseminationEthical approval was obtained from Romagna Ethics Committee (CEROM), study ID 2108, prot. n. IRST 100.28 of 10/04/2020. Informed consent will be obtained from all study participants. Findings will be disseminated through peer-reviewed journals, conferences and event presentations.Protocol versionVersion 2, 6 April 2021.Trial registration numberNCT04826458.
Determinants of undernutrition among older adults in South Gondar Zone, Ethiopia: a community-based study
Authors: Yisak Hiwot , Maru Ismael , Abie Misganaw , Arage Getachew , Ewunetei Amien , Azanaw Melkalem Mamuye , Teshome Fentaw 
Published: January 2022

ObjectivesThe objectives of this study were to assess the prevalence and determinants of undernutrition among older adults aged 65 years in the south Gondar Zone, Ethiopia, in 2020.DesignA community-based cross-sectional study.SettingThe study was conducted from 1 October to 15 December 2020, in the South Gondar Zone, Ethiopia. Study participants were selected by systematic random sampling. A pretested and structured questionnaire adapted from different literature was used to collect data. Anthropometric measurements were taken following the standard procedure.ParticipantsA total of 290 older adults aged greater than or equal to 65 years of age were included in the study.Data analysisDescriptive and summary statistics were employed. Multiple logistic regression was fitted to identify determinants of undernutrition. ORs and their 95% CIs were computed to determine the level of significance.Outcome measuresUndernutrition was assessed by using Body Mass Index and Mini Nutritional Assessment (MNA) tool.ResultsThe prevalence of undernutrition was 27.6% (95% CI 22.4 to 32.8), and 2.1% (95% CI 0.7 to 3.8) of the study participants were overweight. Based on the MNA tool, 29.7% (95% CI 24.5 to 35.2) of the study participants were undernourished and 61.7% (95% CI 55.5 to 67.2) were at risk of undernourishment. Rural residence adjusted OR (aOR)=10.3 (95% CI 3.6 to 29.4), inability to read and write aOR=3.5 (95% CI 1.6 to 7.6), decrease in food intake aOR=13.5 (95% CI 6.1 to 29.5) and household monthly income of less than US$35.6 aOR=4.3 (95% CI 1.9 to 9.4) were significantly and independently associated with undernutrition.ConclusionThe level of undernutrition among older adults in the study area was high, making it an important public health burden. The determinants of undernutrition were a place of residence, educational status, food intake and monthly income.
Optimising treatment expectations in chronic lower back pain through observing others: a study protocol for a randomised clinical trial
Authors: Stuhlreyer Julia , Schwartz Marie , Friedheim Till , Zöllner Christian , Klinger Regine 
Published: January 2022

IntroductionChronic lower back pain (CLBP) is a frequent cause of medical consultations worldwide, and it results in decreased quality of life and disability. Current treatments for CLBP are often not effective, and alternatives are urgently needed. Three promising possibilities have emerged: (1) open-label placebo treatment reduces chronic pain, (2) placebo treatment is as efficacious as opioid treatment with a high correlation between patient expectation and treatment outcome, and (3) observing positive effects in another patient can improve functional capacity. We hypothesise that treatment expectations can be positively influenced through social observation and improve treatment outcome.Methods and analysisIn our clinical trial, we will randomise patients with CLBP into five groups. Two groups receive either a 3 week course of treatment with an analgesic (ANA) (metamizole/dipyrone) or with open-label placebos (OLP). For one of each group, we will build treatment expectations through observational learning and assess its impact on the treatment. For this purpose, one group each will watch either a positive or a neutral video. The intervention groups will be compared with a control group that will not be given any medication or observational learning. Participants will be recruited via all institutions in the Hamburg metropolitan area that treat patients with CLBP. Patients are eligible for inclusion if they are at least 18 years or older, have CLBP (of at least 3 months duration), and agree to potentially receive an active ANA or an OLP. Patients with pain-related “red flags” will be excluded. The study requires 150 participants (30 participants per group) to assess the differences in the primary outcome, pain intensity. Secondary outcomes include changes in treatment expectations, anxiety, comorbid depression, stress-related neuroendocrine measures, functional and structural connectivity, functional capacity, and ANA consumption. All outcomes and treatment expectations will be measured before and after the intervention and 3 months post-intervention.Ethics and disseminationEthical approval was obtained in January 2020 from the Hamburg Medical Ethics Council (ref number PV7067). Outcomes will be disseminated through publications in peer-reviewed journals and presentations at national and international conference meetings.Trial registration numberThe approved trial protocol was registered at the German Clinical Trials Register (DRKS) and can be found at drks.de (Identifier: DRKS00024418).
Quality improvement methodology can reduce hospitalisation for abscess management
Authors: Dunn Michael , Savoie Kate , Erdem Guliz , Dykes Michael W , Buckingham Don , Spencer Sandra , Besner Gail , Kenney Brian 
Published: January 2022

BackgroundAbscesses are a common reason for ED visits. While many are drained in the ED, some require drainage in the operating room (OR). We observed that a higher percentage of patients at our institution in Columbus, Ohio, were admitted to the hospital with abscesses for incision and drainage (I&D) in the OR than other institutions, including paediatric institutions. Our aim was to decrease hospitalisations for abscess management.MethodsA multidisciplinary team convened to decrease hospitalisation for patients with abscesses and completed multiple ‘Plan-Do-Study-Act’ cycles, including increasing I&Ds performed in the ED. Other interventions included implementation of a clinical pathway, training of procedure technicians (PT), updating the electronic medical record (EMR), credentialing advanced practice nurses in sedation and individual follow-up with providers for admitted patients. Data were analysed using statistical process control charts. Gross average charges were assessed.ResultsAdmissions for I&D decreased from 26.3% to 13.7%. Abscess drainage in the ED improved from 79.3% to 96.5%. Mean length of stay decreased from 19.5 to 11.5 hours for all patients. Patients sedated increased from 3.3% to 18.2%. The number of repeat I&Ds within 30 days decreased from 4.3% to 1.7%.ConclusionWe decreased hospitalisations for abscess I&D by using quality improvement methodology. The most influential intervention was an initiative to increase I&Ds performed in the ED. Additional interventions included expanded training of PTs, implementation of a clinical pathway, updating the EMR, improving interdepartmental communication and increasing sedation providers.
Nasobiliary drainage: an effective treatment for pruritus in cholestatic liver disease
Authors: Ahmed Wafaa , Jeyaraj Rebecca , Reffitt David , Devlin John , Suddle Abid , Hunt John , Heneghan Michael A , Harrison Phillip , Joshi Deepak 
Published: January 2022

IntroductionNasobiliary drains (NBDs) have been successfully used to manage intrahepatic cholestasis, bile leaks and obstructive cholangitis. It allows external drainage of bile, bypassing the ileum where bile salts are reabsorbed. We assessed the utility of placement with effect on markers of cholestasis and patient symptoms.MethodsConsecutive patients undergoing NBD over 12 years for the management of pruritus were retrospectively analysed. Recorded variables included patient demographics, procedural characteristics and response to therapy.ResultsTwenty-three patients (14, 61% male) underwent 30 episodes of NBD. The median age was 26 years old (range 2–67 years old). A single procedure was carried out in 20. One patient each had two, three and five episodes of NBD. The most common aetiologies were hereditary cholestatic disease (n=17, 74%) and drug-induced cholestasis (n=5, 22%),NBD remained in situ for a median of 8 days (range 1–45 days). Significant improvement in bilirubin was seen at 7 days post-NBD (p=0.0324), maintained at day 30 (335 μmol/L vs 302 µmol/L vs 167 µmol/L). There was symptomatic improvement in pruritus in 20 (67%, p=0.0494) episodes. One patient underwent NBD during the first trimester of pregnancy after medical therapy failure with a good symptomatic response. The catheters were well tolerated in 27 (90%) of cases. Mild pancreatitis occurred in 4 (13%) cases.ConclusionNBD can be used to provide symptomatic improvement to patients with pruritus associated with cholestasis. It is well tolerated by patients. They can be used in pregnancy where medical management has failed.
Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression
Authors: Ruivo Carolina F , Bastos Nuno , Adem Barbara , Batista Ines , Duraes Cecilia , Melo Carlos A , Castaldo Stephanie A , Campos‐Laborie Francisco , Moutinho-Ribeiro Pedro , Morão Barbara , Costa-Pinto Ana , Silva Soraia , Osorio Hugo , Ciordia Sergio , Costa Jose Luis , Goodrich David , Cavadas Bruno , Pereira Luisa , Kouzarides Tony , Macedo Guilherme , Maio Rui , Carneiro Fatima , Cravo Marília , Kalluri Raghu , Machado Jose Carlos , Melo Sonia A 
Published: January 2022

ObjectiveIntratumor heterogeneity drives cancer progression and therapy resistance. However, it has yet to be determined whether and how subpopulations of cancer cells interact and how this interaction affects the tumour.DesignWe have studied the spontaneous flow of extracellular vesicles (EVs) between subpopulations of cancer cells: cancer stem cells (CSC) and non-stem cancer cells (NSCC). To determine the biological significance of the most frequent communication route, we used pancreatic ductal adenocarcinoma (PDAC) orthotopic models, patient-derived xenografts (PDXs) and genetically engineered mouse models (GEMMs).ResultsWe demonstrate that PDAC tumours establish an organised communication network between subpopulations of cancer cells using EVs called the EVNet). The EVNet is plastic and reshapes in response to its environment. Communication within the EVNet occurs preferentially from CSC to NSCC. Inhibition of this communication route by impairing Rab27a function in orthotopic xenographs, GEMMs and PDXs is sufficient to hamper tumour growth and phenocopies the inhibition of communication in the whole tumour. Mechanistically, we provide evidence that CSC EVs use agrin protein to promote Yes1 associated transcriptional regulator (YAP) activation via LDL receptor related protein 4 (LRP-4). Ex vivo treatment of PDXs with antiagrin significantly impairs proliferation and decreases the levels of activated YAP.Patients with high levels of agrin and low inactive YAP show worse disease-free survival. In addition, patients with a higher number of circulating agrin+EVs show a significant increased risk of disease progression.ConclusionPDAC tumours establish a cooperation network mediated by EVs that is led by CSC and agrin, which allows tumours to adapt and thrive. Targeting agrin could make targeted therapy possible for patients with PDAC and has a significant impact on CSC that feeds the tumour and is at the centre of therapy resistance.
Effect of stroke etiology on endovascular thrombectomy with or without intravenous alteplase: a subgroup analysis of DIRECT-MT
Authors: Xing Pengfei , Zhang Xiaoxi , Shen Hongjian , Shen Fang , Zhang Lei , Li Zifu , Zhang Yongxin , Hong Bo , Shi Huaizhang , Han Hongxing , Ye Xiaofei , Zhang Yongwei , Yang Pengfei , Liu Jianmin 
Published: January 2022

BackgroundStroke etiology might influence the clinical outcomes in patients with large vessel occlusion receiving endovascular treatment (EVT) with or without thrombolysis.ObjectiveTo examine whether stroke etiology resulted in different efficacy and safety in patients treated with EVT-alone or EVT preceded by intravenous alteplase (combined therapy).MethodsWe assessed the efficacy and safety of treatment strategy based on prespecified stroke etiology, cardioembolism (CE), large-artery atherosclerosis (LAA), and undetermined cause (UC) for patients enrolled in the DIRECT-MT trial. The primary outcome was the modified Rankin Scale (mRS) score at 90 days. Multivariate ordinal logistic regression analysis was used to calculate the adjusted common OR for a shift of better mRS score for EVT-alone versus combined therapy. A term was entered to test for interaction.ResultsIn this study, 656 patients were grouped into three prespecified stroke etiologic subgroups. The adjusted common ORs for improvement in the 90-day ordinal mRS score with EVT-alone were 1.2 (95% CI 0.8 to 1.8) for CE, 1.6 (95% CI 0.8 to 3.3) for LAA, and 0.8 (95% CI 0.5 to 1.3) for UC. Compared with CE, EVT-alone was more likely to result in an mRS score of 0–1 (pinteraction=0.047) and extended Thrombolysis in Cerebral Infarction ≥2b (pinteraction=0.041) in the LAA group. The differences in mortality and symptomatic intracranial hemorrhage within 90 days were not significant between the subgroups (p＞0.05).ConclusionsThe results did not support the hypothesis that a specific treatment strategy based on stroke etiology should be used for patients with large vessel occlusion (NCT03469206).
Muscle hypertrophy and strength gains after resistance training with different volume-matched loads: a systematic review and meta-analysis
Authors: Carvalho Leonardo , Junior Roberto Moriggi , Barreira Júlia , Schoenfeld Brad J. , Orazem John , Barroso Renato 
Published: January 2022

The purpose of this paper was to conduct a systematic review and meta-analysis of studies that compared muscle hypertrophy and strength gains between resistance training protocols employing very low (VLL < 30% of 1-repetition maximum (RM) or >35RM), low (LL30%–59% of 1RM, or 16–35RM), moderate (ML60%–79% of 1RM, or 8–15RM), and high (HL ≥ 80% of 1RM, or ≤7RM) loads with matched volume loads (sets × repetitions × weight). A pooled analysis of the standardized mean difference for 1RM strength outcomes across the studies showed a benefit favoring HL vs. LL and vs. ML and favoring ML vs. LL. The LL and VLL results showed little difference. A pooled analysis of the standardized mean difference for hypertrophy outcomes across all studies showed no differences between training loads. Our findings indicate that when the volume load is equal between conditions, the highest loads induce superior dynamic strength gains. Alternatively, hypertrophic adaptations were similar irrespective of the load magnitude. Novelty: Training with higher loads elicits greater gains in 1RM muscle strength when compared to lower loads, even when the volume load is equal between conditions. Muscle hypertrophy is similar irrespective of the magnitude of the load, even when the volume load is equal between conditions.
Quantum-tunneling transitions and exact statistical mechanics of bistable systems with parametrized Dikandé–Kofané double-well potentials
Authors: Nzoupe F. Naha , Dikandé Alain M. , Tchouobiap S. E. Mkam 
Published: January 2022

Abstract
We consider a one-dimensional system of interacting particles (which can be atoms, molecules, ions, etc.), in which particles are subjected to a bistable potential the double-well shape of which is tunable via a shape deformability parameter. Our objective is to examine the impact of shape deformability on the order of transition in quantum tunneling in the bistable system, and on the possible existence of exact solutions to the transfer-integral operator associated with the partition function of the system. The bistable potential is represented by a class composed of three families of parametrized double-well potentials, whose minima and barrier height can be tuned distinctly. It is found that the extra degree of freedom, introduced by the shape deformability parameter, favors a first-order transition in quantum tunneling, in addition to the second-order transition predicted with the $$\phi ^4$$

ϕ
4

model. This first-order transition in quantum tunneling, which is consistent with Chudnovsky’s conjecture of the influence of the shape of the potential barrier on the order of thermally assisted transitions in bistable systems, is shown to occur at a critical value of the shape-deformability parameter which is the same for the three families of parametrized double-well potentials. Concerning the statistical mechanics of the system, the associate partition function is mapped onto a spectral problem by means of the transfer-integral formalism. The condition that the partition function can be exactly integrable, is determined by a criterion enabling exact eigenvalues and eigenfunctions for the transfer-integral operator. Analytical expressions of some of these exact eigenvalues and eigenfunctions are given, and the corresponding ground-state wavefunctions are used to compute the probability density which is relevant for calculations of thermodynamic quantities such as the correlation functions and the correlation lengths.

Graphic Abstract
Transverse-momentum resummation for boson plus jet production at hadron colliders
Authors: Buonocore Luca , Grazzini Massimiliano , Haag Jürg , Rottoli Luca 
Published: January 2022

AbstractWe consider the associated production of a vector or Higgs boson with a jet in hadronic collisions. When the transverse momentum $$q_T$$

q
T

of the boson-jet system is much smaller than its invariant mass Q, the QCD perturbative expansion is affected by large logarithmic terms that must be resummed to all orders. We discuss the all-order resummation structure of the logarithmically enhanced contributions up to next-to-leading logarithmic accuracy. Resummation is performed at the differential level with respect to the kinematical variables of the boson-jet system. Soft-parton radiation produces azimuthal correlations that are fully accounted for in our framework. We present explicit analytical results for the resummation coefficients up to next-to-leading order and next-to-leading logarithmic accuracy, that include the exact dependence on the jet radius.
Impact of $$b \rightarrow s \ell \ell $$ anomalies on rare charm decays in non-universal $$Z'$$ models
Authors: Alok Ashutosh Kumar , Chundawat Neetu Raj Singh , Kumar Dinesh 
Published: January 2022

AbstractIn this work, we study the impact of$$b \rightarrow s \ell \ell $$b→sℓℓ,$$B_s - \bar{B_s}$$Bs-Bs¯mixing and neutrino trident measurements on observables in decays induced by$$c \rightarrow u $$c→utransition in the context of a non-universal$$Z'$$Z′model which generates$$C^{\mathrm{NP}}_{9} <0$$C9NP<0and$$C^{\mathrm{NP}}_9 = - \,C^{\mathrm{NP}}_{10} $$C9NP=-C10NPnew physics scenarios at the tree level. We inspect the effects on$$D^0 \rightarrow \pi ^0 \nu {\bar{\nu }}$$D0→π0νν¯,$$D^+ \rightarrow \pi ^+ \nu {\bar{\nu }}$$D+→π+νν¯and$$B_c \rightarrow B^+ \nu {\bar{\nu }} $$Bc→B+νν¯decays which are induced by the quark level transition$$c \rightarrow u \nu {\bar{\nu }}$$c→uνν¯. The fact that the branching ratios of these decays are negligible in the standard model (SM) and the long distance effects are relatively smaller in comparison to their charged dileptons counterparts, they are considered to provide genuine null-tests of SM. Therefore the observation of these modes at the level of current as well as planned experimental sensitivities would imply unambiguous signature of new physics. Using the constraints on$$Z'$$Z′couplings coming from a combined fit to$$b \rightarrow s \ell \ell $$b→sℓℓ,$$\varDelta M_s$$ΔMsand neutrino trident data, we find that any meaningful enhancement over the SM value is ruled out in the considered framework. The same is true for$$D - {\bar{D}}$$D-D¯mixing observable$$\varDelta M_D$$ΔMDalong with$$D^0 \rightarrow \mu ^+ \mu ^-$$D0→μ+μ-and$$D^+ \rightarrow \pi ^+ \mu ^+ \mu ^-$$D+→π+μ+μ-decay modes which are induced through$$c \rightarrow u \mu ^+ \mu ^-$$c→uμ+μ-transition.