bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rock With Lots Of Holes
Authors: Kostandini Silvia 
Published: April 2022

We perceive our surroundings differently when fully engaged with them. Interactions with spaces begin to define our experience of the world. This research is a modern story of matter and philosophy, investigating the rock Scoria to produce a series of public architectural spaces that uniquely engage with the beholder. By taking part in the Material Imaginaries Research Collective - AUT Spatial Design department - I ask the following: 'What is our world made of? How might an expanded sense of 'material' and a focus on meaning, provenance, story, and performance recast how we make space?' With an imaginary read on the rock Scoria, the research explores both abstract and tangible ways to unfold a narrative of matter. Engaging with geographical, cultural, and social aspects that define the scoriaceous element and its connection to the “Tamaki Makaurau Volcanic landscape” (Tūpuna Maunga Authority). The exploration of Scoria's materiality becomes the driving aspect of the study, bridging learning and processes into practice-led research to uncover the existing history of the volcanic rock, challenging conventional methods and developing Le Mappe Del Mondo, Lavoro Manuale, and Il Giornale as a creative alternative to organize the various tools and techniques that shape the creative practice. The choice to incorporate Italian terminology becomes a playful way to acknowledge my background through the research. The project wishes to provide a set of interventions that engage with the geographical heritage features of Tāmaki Makarau in shaping a collection of public gathering spaces that activate unfurnished and unutilized areas around the territory. By celebrating the Tūpuna Maunga to showcase the heritage values associated with preserving those sites and considering the broader landscape's role in supporting our growth as a society. By providing a range of public spaces for the collective, such as gatherings and recreation, the designer considers all the components to ensure “sustainable” (Project for Public Spaces) city life engagement.
Iti noa ana, he pito mata: A critical analysis of educational success through a Māori lens and two case studies of whānau within Ngāti Awa and Ngāti Tūwharetoa
Authors: Abraham Hazel 
Published: April 2022

The educational success of Māori students is of high national interest and priority in New Zealand. A plethora of educational research exists on how to lift student achievement and the need for indigenous views in transforming outcomes for Māori (Macfarlane, 2015). This presentation shines a spotlight on Māori whānau (families’) perspectives of the challenges and barriers to academic success they encountered on their educational journey in mainstream schooling. Insights yielded from this doctoral research by Māori whānau offer an opportunity to rethink the overall role and purpose of educational success for future generations of Māori whānau. The research draws upon Western theories merged with Indigenous methodologies, such as Kaupapa Māori Theory (Smith, 2012) and Pūrakau (story telling) (Lee, 2009), to unravel the narratives of the past and present. Two case studies of whānau from Ngāti Awa and Ngāti Tūwharetoa provided insight into the interconnected relationship between cultural trauma and educational success. Interviews with these whānau uncover themes that informed the creation of a model called ‘He rere pepepe ki te anuhe Framework’ – Transforming pathways for whānau through educational success. This model offers restorative solutions that offer optimism for a new future. It is a critical response to the issues facing Māori in New Zealand’s education system within the Eastern Bay of Plenty. The research findings affirm that systemic bias exists in New Zealand’s education system and has had a detrimental impact on the educational success of tamariki Māori (Māori children) and whānau across many successive generations. A major finding identified from the two case studies is that Māori have not recovered from colonisation, particularly the impact of 204 years of historical and cultural trauma experienced across successive generations of whānau that has resulted in the loss of language, culture and identity.
Bivalirudin exerts antiviral activity against respiratory syncytial virus-induced lung infections in neonatal mice
Authors: Zhuang Shihao , Tang Qiuyu , Chen Ping , Wang Chengyi , Liu Guanghua 
Published: April 2022

Abstract
Respiratory syncytial virus (RSV) is the most common cause of small airways inflammation in the lungs (bronchiolitis) in neonates and immunocompromised adults. The deregulation of cellular and plasma components leads to increased morbidity and mortality. The activation of the clotting cascade plays a key role in the progression of disease severity during viral infection. The current investigation studied the effect of bivalirudin (BR) on the progression and cellular effects of RSV-induced infection in the neonatal mice model. Mice (5–7 days old) were inoculated intranasally with RSV with or without BR administration (2 mg kg−1 day−1, i.v.) for 2 weeks. Tissue histopathology, inflammatory signalling genes such as TLR, and cytokines were analyzed. The results showed pneumocytes exhibiting nuclear pyknosis, cellular infiltration in lung tissue and increased lung titers in RSV-infected mice compared to the control. Furthermore, RSV-infected mice demonstrated altered clotting parameters such as D-dimer, soluble thrombomodulin, and increased inflammatory cytokines IL-5, 6, IFN-γ, IL-13, and CXCL1. Additionally, the mRNA expression analysis displayed increased levels of IL-33, TLR3, and TLR7 genes in RSV-infected lung tissue. Further, to delineate the role of micro RNAs, the qRT-PCR analysis was done, and the results displayed an increase in miR-136, miR-30b, and let-7i. At the same time, the down-regulated expression of miR-221 in RSV-infected mice compared to the control. BR treatment reduced the cellular infiltration with reduced inflammatory cytokines and normalized clotting indices. Thus, the study shows that RSV infection induces specific changes in lung tissue and the clotting related signalling mechanism. Additionally, BR treatment significantly reduces bronchiolitis and prevents the severity of the infections suggesting that BR can possibly be used to reduce the viral-mediated infections in neonates.
Dasatinib enhances curcumin-induced cytotoxicity, apoptosis and protective autophagy in human schwannoma cells HEI-193: The role of Akt/mTOR/p70S6K signalling pathway
Authors: Pang Pengfei , Zhang Shirong 
Published: April 2022

Abstract
The present study was carried out in human schwannoma cells (HEI-193) to determine the combined anti-cancer effect of curcumin and dasatinib. Cells were treated with curcumin only, dasatinib only, or the combination of curcumin and dasatinib for 24 hours. Cellular toxicity, cell proliferation, and cell death were determined by LDH, MTT, and trypan blue dye assays, respectively. ELISA based kit was used to determine apoptotic cell death. Western blotting was used to determine the expression of apoptotic and autophagy-associated protein markers. Similarly, expression levels of Akt/mTOR/p70S6K signalling pathway-related proteins were studied using Western blotting. Cell death and apoptosis were significantly higher in HEI-193 cells treated with curcumin and dasatinib combination compared to individual controls. The combination of curcumin and dasatinib significantly enhances autophagy markers compared to individual controls. Furthermore, the combination of curcumin and dasatinib significantly activates Akt/mTOR/p70S6K signalling pathway compared to individual controls. In conclusion, our results suggest that the combination of curcumin and dasatinib significantly enhances cytotoxicity, apoptosis, and protective autophagy in HEI-193 cells through Akt/mTOR/p70S6K signalling pathway.
Fingolimod exerts in vitro anticancer activity against hepatocellular carcinoma cell lines via YAP/TAZ suppression
Authors: Du Jiamin , Qian Meijia , Yuan Tao , Zhang Bo , Chen Xueqin , An Ning , He Qiaojun , Yang Bo , Ye Song , Zhu Hong 
Published: April 2022

Abstract
Hepatocellular carcinoma (HCC) remains a notably global health challenge with high mortality rates and poor prognosis. The deregulation of the Hippo signalling pathway, especially the overexpression and activation of downstream effector Yes-associated protein (YAP), has been demonstrated to result in the rapid malignant evolution of HCC. In this context, multiple efforts have been dedicated to targeting YAP for HCC therapy, but effective YAP inhibitors are still lacking. In this study, through a YAP-TEAD (8×GTIIC) luciferase reporter assay, we identified fingolimod, an immunomodulatory drug approved for the treatment of multiple sclerosis, as a novel YAP inhibitor. Fingolimod suppressed the proliferation of HCC cell lines by downregulating the protein levels as well as the trans-activating function of YAP. Overall, our current study not only identifies fingolimod as a novel YAP-targeting in hibitor, but also indicates that this clinically-approved drug could be utilized as a potential and feasible therapeutic drug for HCC.
Polyphenol content and antioxidant activity of phytoestrogen containing food and dietary supplements: DPPH free radical scavenging activity by HPLC
Authors: Klarić Daniela Amidžić , Mornar Ana , Kovačić Jelena , Jeličić Mario-Livio , Brusač Edvin , Brletić Iva , Klarić Ilija 
Published: April 2022

Abstract
Soy, red clover, chaste tree, hop and flax have all been found to contain a wide range of phytoestrogenic compounds, and a large number of dietary supplements contain their extracts as principal ingredients. This study is aimed to evaluate the total polyphenolic content and antioxidant activity of phytoestrogen-containing food and formulated dietary supplements. The HPLC-DPPH method was applied for DPPH free radical scavenging activity testing of various phytoestrogen-containing samples. Polyphenol content and antioxidant activity in dietary supplements were higher than in functional food samples; multiple-botanical-source preparations showed higher polyphenol content and antioxidant activity than the mono-botanical counterparts. Furthermore, the correlation between polyphenol content and anti-oxidant activity was strongly statistically significant, so it might be concluded that antioxidant activity is proportional to the content of these secondary metabolites. The most striking batch-to-batch deviations were represented by one chaste berry-based product (RSD 41.3 %) and one red clover derived product (RSD 57.9 %). The results of this study contribute to a better understanding of the phenolic profile and antioxidant properties of phytoestrogen containing food and dietary supplements.
Artificial Intelligence or the Ultimate Tool for Conservatism
Authors: Marcinowski Maciej 
Published: April 2022

Abstract
Artificial intelligence (AI) is foremost viewed as a technologically revolutionary tool, however, the author discusses here whether it is in fact a tool for socio-economic and legal conservatism, because its training data is always embedded in the past. The aim of this paper is to explain, exemplify and predict – whether and how – AI could cause discrimination, stagnation and uniformization by conserving what is relayed even by the most representative data. Furthermore, the author aims to propose possible legal barriers to these phenomena. The presented hypotheses are based upon empirical research and socioeconomic or legal mechanisms, aiming to predict possible results of AI applications under specific conditions. Results indicate that the inherent AI conservatism could indeed cause severe discrimination, stagnation and uniformization, especially if its applications were to remain unquestioned and unregulated. Hopefully, the proposed legal solutions could limit the scope and effectiveness of AI conservatism, encouraging AI-related solutions.
Analysis of Legal Powers of Municipal Wardens they Possess to Ensure Safety At the Local Level
Authors: Dvojmoč Miha , Tičar Bojan 
Published: April 2022

Abstract
In Slovenia, the Municipal Warden Services Act (ZORed, 2006, and ZORed-A, 2017) represents the framework organisational legal act regulating the field of work of municipal wardens. In addition to the above act, the field of work and tasks performed by municipal wardens are also regulated by other laws and by-laws. Legal regulations enable and allow authorised persons of municipal warden services to use repressive powers in ensuring security. The article thus presents the security powers of municipal wardens from the point of view of the applicable Slovenian legal order. The article is a scientific review based on grammatical and dogmatic interpretation of applicable legal regulations and selected decisions of the Constitutional Court of the Republic of Slovenia, and on an analytical method of the review of the Slovenian legislation in the field in question. The legal methods used by the author also include a synthetic method of comparing the legislation from the underlying Municipal Warden Services Act (ZORed, 2006) and its main amendments set out in the ZORed-A (2017). The paper is a comprehensive review of measures that municipal wardens may use to ensure safety at the local level. The author lists the relevant scientific and professional literature and argues about polemic issues with other prominent Slovenian authors. In Slovenia, laws are being amended, giving more and more powers to municipal wardens. The conceptual changes introduced by the ZORed-A (2017) have resolved some ambiguities, such as the addition/amendment of articles relating to the conditions for performing municipal warden tasks and supervision over their use, but a comprehensive and systematic amendment of municipal warden services legislation would nevertheless be useful.
Short-Term Hypergravity-Induced Changes in Growth, Photo synthetic Parameters, and Assessment of Threshold Values in Wheat (Triticum aestivum L.)
Authors: Dixit Jyotsana , Jagtap Sagar , Vidyasagar Pandit 
Published: April 2022

Abstract
The reduction in growth and development of plants constantly exposed to different ranges of hypergravity (acceleration more than 1 g) is adequately documented. However, earlier studies did not reveal the threshold hypergravity value at which these effects were seen. The understanding of the threshold g-value is an important consideration while we plan hypergravity experiments as different plants can perceive and respond differently at the same g-value. The aim of the present work is to study the effect on growth and photosynthetic parameters as well as to assess the threshold values in wheat seedlings grown from hypergravity-exposed seeds. Healthy wheat seeds were immersed in distilled water for 24 hours and exposed to hypergravity values ranging from 200 g to 1,000 g for a short duration of 10 minutes and sown on 0.8% agar gel. All the measurements were done on the fifth day after sowing. Results obtained showed significant reduction in growth and photosynthetic parameters in seedlings raised from hypergravity-treated wheat seeds. Interestingly, the reduction was started at 400 g and was found to reach a maximum at 1,000 g. Probably this would be the first study reporting the threshold of high g forces for growth and photosynthetic parameters when seeds were exposed to hypergravity.
Low Cost Avionics System for Ultralight Aircraft
Authors: Górski Filip , Inglot Dawid , Wojnar Rafał , Kopecki Grzegorz 
Published: April 2022

Abstract
The article presents a low cost avionics system for ultralight aircraft and paraplanes. The system contains Attitude and Heading Reference System, Air Data Computer and Primary Flight Display. Communication between units is via Wi-Fi. In the article design description was presented, as well as laboratory tests results. They are promising and the system is ready for in flight testing.
Random Forest in the Tests of Small Caliber Ammunition
Authors: Ampuła Dariusz 
Published: April 2022

Abstract
In the introduction of this article the method of building a random forest model is presented, which can be used for both classification and regression tasks. The process of designing the random forest module was characterized, paying attention to the classification tasks module, which was used to build the author’s model. Based on the test results, a random forest model was designed for 7,62 mm ammunition with T-45 tracer projectile. Predictors were specified and values of stop parameters and process stop formulas were determined, on the basis of which a random forest module was built. An analysis of the resulting random forest model was made in terms of assessing its prediction and risk assessment. Finally, the designed random forest model has been refined by adding another 50 trees to the model. The enlarged random forest model occurred to be slightly stronger and it should be implemented.
How to find a suitable location for a cemetery? Application of multi-criteria evaluation for identifying potential sites for cemeteries in Białystok, Poland
Authors: Długozima Anna 
Published: April 2022

Abstract
Valorisation of land is an important tool for countries around the world to help regulate land use planning and ensure sustainable development. Cemeteries are multifaceted spaces, providing a keystone community infrastructure. Poorly located cemeteries can generate adverse environmental, landscape and community outcomes. Identifying optimal sites for cemeteries will become an increasing concern for land use planners as population numbers and consequent death rates increase while the amount of available land decreases. This study was conducted with the aim of proposing multi-criteria analysis for identifying some optimal sites for cemeteries. This analysis was implemented in Białystok (297,585 inhabitants, in Podlaskie Voivodeship, Poland), where 11 potential areas for the location of a new cemetery were assessed. Through a comprehensive process of investigation, engagement, and analysis, four options in different locations were identified as suitable for further consideration. Two sites (options 7 and 11) had fatal flaws – high risk and effects associated with development and were not recommended to be taken forward.
Perception of safety and passage of time as factors influencing mode choice: The case of the Prague-Munich high-speed route
Authors: Petříček Jakub , Marada Miroslav 
Published: April 2022

Abstract
Behavioural factors of risk perception and time perception influencing the mode choice on the Prague-Munich route in relation to railway as a reference mode, are subject to evaluation in this article. Semi-structured interviews are qualitatively analysed using the Grounded Theory method and ATLAS.ti software, giving specific sets of meanings and understandings of selected factors, which in turn affect the travel behaviours and the mode choice. Defining these factors creates space for estimating and proposing perspectives for the development of expected travel behaviours in the context of the planned high-speed rail (HSR) system on the Prague-Munich route. The significance of this research lies in creating new meaning fields of selected factors in the specific transport infrastructure with four existing transport modes between Prague and Munich. The results based on the formulated concepts show two different meaning fields of risk – the concept of perceived risk of an accident and the concept of personal safety. Empirical results of time perception show four different meaning fields of time perception based on a preferred transport mode. Finally, the results are used for creating contextual perspectives for HSR planning across Czech – German borders.
Investigation of the Causes and Factors Generating Land Instability in the Berbeşti Mining Basin
Authors: Apostu Izabela-Maria , Rada Constantin , Lazăr Maria , Faur Florin , Sîli Nicolae 
Published: April 2022

Abstract
Romania’s new commitments to give up coal-based energy production entail the gradual closure of the last four open-pits in operation in Berbești Mining Basin, thus, raising the issue of primarily ensuring the stability of the lands in these perimeters in order to reintroduce them, too, into the economic circuit as soon as possible. Considering the numerous negative geo-mining phenomena that have taken place over time in the perimeters of Berbești Mining Basin, respectively landslides and other types of geotechnical phenomena, it is necessary to investigate the causes and factors that favor their manifestation so that their influence can be reduced, removed or simply taken into resizing calculations. The paper presents the results of a study whose purpose is to investigate the factors and causes that generate phenomena of instability of natural and artificial slopes in the area of Berbești Mining Basin. The main research methods applied in this paper were in situ observations, analyzes and laboratory tests, identification of rock types and their behaviors in various weather and humidity conditions, determination of physical and mechanical characteristics, and interpretation of results.
The Impact of Macroprudential Policy Instruments on Financial Stability in Southern Europe
Authors: Lorenčič Eva , Festić Mejra 
Published: April 2022

Abstract
This paper is a contribution to the body of research examining the impact of macroprudential policy instruments on financial stability. The following hypothesis was tested (H1): Macroprudential policy instruments (household borrowing costs; interbank loans as a percentage of total loans; loan to deposit ratio; leverage ratio; and solvency ratio) enhance financial stability, as measured by credit growth, in four southern European economies (Greece, Italy, Portugal and Spain) from Q4 2010 to Q4 2018. The empirical results of this study suggest that, of the investigated macroprudential policy instruments, household borrowing costs, interbank loans as a percentage of total loans and loan to deposit ratio exhibit the predicted impact on credit growth rate. Leverage ratio and solvency ratio do not exhibit the expected impact on the response variable. Moreover, only three out of the five explanatory variables are statistically significant in the model. Consequently, it is not possible to confirm or reject the hypothesis based on the available data and results.
Preparation of hexamethylol melamine resin with low crystallization water and low viscosity for hexamethylol melamine/polyvinyl alcohol composite membrane
Authors: Liu Xing-Jian , Guo Yan-Wen , Zheng Jian-Fei , Wu Jiang , Hu Bing 
Published: April 2022

Abstract
Hexamethylol melamine resins (HMM) with low crystallization water content and low viscosity were prepared by inhibiting the condensation polymerization of low hexamethylol melamine. The effects of catalyst, pH, formalde-hyde/melamine ratio, reaction temperature and time on the synthesis parameters of HMM were investigated. The results showed that the sample (HMM8) synthesized with Na2CO3-NaHCO3 as catalyst had the crystallization water content lower than 10%, being with a viscosity of about 0.26 Pa·s. The melting temperature of HMM8/polyvinyl alcohol (PVA) curing system was about 164.3 °C. It was found that the higher the amount of formaldehyde, the greater the hydroxyl methyl bounded to each triazine ring. Compared with the traditional melamine formaldehyde resin which had the crystallization water content of about 20–30%, the production of this resin was expected to reduce the energy consumption of industrial reaction, while the resin with 10% crystallization water content was more conducive to the development of alloying HMM/PVA composite membrane.