bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Canada’s menthol cigarette ban on quitting among menthol smokers: pooled analysis of pre–post evaluation from the ITC Project and the Ontario Menthol Ban Study and projections of impact in the USA
Authors: Fong Geoffrey T , Chung-Hall Janet , Meng Gang , Craig Lorraine V , Thompson Mary E , Quah Anne C K , Cummings K Michael , Hyland Andrew , O'Connor Richard J , Levy David T , Delnevo Cristine D , Ganz Ollie , Eissenberg Thomas , Soule Eric K , Schwartz Robert , Cohen Joanna E , Chaiton Michael O 
Published: May 2022

IntroductionBetween 2015 and 2018, Canada banned menthol cigarettes. This study pooled data from two pre–post cohort studies (the Ontario Menthol Ban Study, and the International Tobacco Control Policy Evaluation (ITC) Canada Survey, conducted in seven provinces) to derive more precise estimates of the impact of Canada’s menthol ban on quitting and to apply these estimates to project the impact of a menthol ban in the USA.MethodsWeighted multivariable logistic analyses compared post-ban quit success of menthol smokers with non-menthol smokers (for daily smokers and for all (daily + non-daily) smokers), controlling for sex, age, ethnicity, education, baseline smoking status, baseline cigarettes per day and study regions. Projections to the USA were created by multiplying the effect size of the Canadian menthol ban on quitting (percentage of increased quitting among menthol smokers) by the number of menthol smokers overall and among African Americans, from the 2019 National Survey on Drug Use and Health.ResultsAfter the menthol cigarette ban, menthol smokers were more likely than non-menthol smokers to have quit smoking among daily smokers (difference=8.0%; 95% CI: 2.4% to 13.7%,p=0.005) and all (daily+non-daily) smokers (difference=7.3%; 95% CI: 2.1% to 12.5%,p=0.006). The projected number of smokers who would quit after a US menthol ban would be 789 724 daily smokers (including 199 732 African Americans) and 1 337 988 daily+non-daily smokers (including 381 272 African Americans).ConclusionsThis pooled analysis of Canada’s menthol cigarette ban provides the foundation for estimating the impact of menthol bans in the USA and other countries. Projections suggest that a US menthol cigarette ban would have a substantial impact on increasing quitting.
Protogynous hermaphroditism in Crustacea: a new example from Tanaidacea
Authors: Kakui Keiichi , Hiruta Chizue 
Published: May 2022

Hermaphroditism has been widely reported in the Crustacea, but protogyny, in which females change to males, is apparently rare and restricted to the peracarid orders Isopoda and Tanaidacea. In the latter, protogyny has been demonstrated in only seven species representing six genera by rearing experiments and indicated for several other genera and species through morphology. Here, we show through rearing experiment and histological observations, protogynous hermaphroditism in the tanaidacean species Nesotanais sp. aff. ryukyuensis Kakui, Kajihara and Mawatari, 2010. Our rearing experiment and size distribution data for wild individuals showed that females can change sex at various sizes (= ages). We found one individual identified externally as a female containing both ovaries and testes, indicating that overt female individuals undergo a short transitional phase as simultaneous hermaphrodites before the sex-change molt. We discuss the relationship among the wide size distribution of sex-changing females, the short life span of males, and the tube-dwelling mode of life.
Effects of order $$\alpha ^3$$ on the determination of the Pauli form factor $$F_2$$ of the $$\tau $$-lepton
Authors: Krinner F. , Kaiser N. 
Published: May 2022

AbstractWe introduce optimal observables to measure the Pauli form factor$$F_2$$F2of the$$\tau $$τ-lepton in the pair-production process$$\mathrm{e}^- \mathrm{e}^+ \rightarrow \tau ^-\tau ^+$$e-e+→τ-τ+from the intensity distribution of the decay products. The spin-density matrix for the production process is calculated in QED up to order$$\alpha ^3$$α3including virtual photon-loops and soft bremsstrahlung, as well the$$\gamma Z^0$$γZ0interference. We find that the decay channel$$(\rho ^-\nu _\tau )\times (\rho ^+ {\bar{\nu }}_\tau )$$(ρ-ντ)×(ρ+ν¯τ)yields the best resolution for Re$$F_2(s)$$F2(s)and Im$$F_2(s)$$F2(s)due to its high branching fraction. We also study the bias that is introduced in the determination of$$F_2$$F2, if the production spin-density matrix is taken in tree-level (one-photon exchange) approximation.
Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients
Authors: Crisafulli Giovanni , Sartore-Bianchi Andrea , Lazzari Luca , Pietrantonio Filippo , Amatu Alessio , Macagno Marco , Barault Ludovic , Cassingena Andrea , Bartolini Alice , Luraghi Paolo , Mauri Gianluca , Battuello Paolo , Personeni Nicola , Zampino Maria Giulia , Pessei Valeria , Vitiello Pietro Paolo , Tosi Federica , Idotta Laura , Morano Federica , Valtorta Emanuele , Bonoldi Emanuela , Germano Giovanni , Di Nicolantonio Federica , Marsoni Silvia , Siena Salvatore , Bardelli Alberto 
Published: May 2022

Abstract

The majority of metastatic colorectal cancers (mCRC) are mismatch repair (MMR) proficient and unresponsive to immunotherapy, whereas MMR-deficient (MMRd) tumors often respond to immune-checkpoint blockade. We previously reported that the treatment of colorectal cancer preclinical models with temozolomide (TMZ) leads to MMR deficiency, increased tumor mutational burden (TMB), and sensitization to immunotherapy. To clinically translate these findings, we designed the ARETHUSA clinical trial whereby O6-methylguanine-DNA-methyltransferase (MGMT)–deficient, MMR-proficient, RAS-mutant mCRC patients received priming therapy with TMZ. Analysis of tissue biopsies and circulating tumor DNA (ctDNA) revealed the emergence of a distinct mutational signature and increased TMB after TMZ treatment. Multiple alterations in the nucleotide context favored by the TMZ signature emerged in MMR genes, and the p.T1219I MSH6 variant was detected in ctDNA and tissue of 94% (16/17) of the cases. A subset of patients whose tumors displayed the MSH6 mutation, the TMZ mutational signature, and increased TMB achieved disease stabilization upon pembrolizumab treatment.

Significance:
MMR-proficient mCRCs are unresponsive to immunotherapy. We provide the proof of concept that inactivation of MMR genes can be achieved pharmacologically with TMZ and molecularly monitored in the tissue and blood of patients with mCRC. This strategy deserves additional evaluation in mCRC patients whose tumors are no longer responsive to standard-of-care treatments.
See related commentary by Willis and Overman, p. 1612.
This article is highlighted in the In This Issue feature, p. 1599
Distinct Patterns of Clonal Evolution Drive Myelodysplastic Syndrome Progression to Secondary Acute Myeloid Leukemia
Authors: Guess Tiffany , Potts Chad R. , Bhat Pawan , Cartailler Justin A. , Brooks Austin , Holt Clinton , Yenamandra Ashwini , Wheeler Ferrin C. , Savona Michael R. , Cartailler Jean-Philippe , Ferrell P. Brent 
Published: May 2022

AbstractClonal evolution in myelodysplastic syndrome (MDS) can result in clinical progression and secondary acute myeloid leukemia (sAML). To dissect changes in clonal architecture associated with this progression, we performed single-cell genotyping of paired MDS and sAML samples from 18 patients. Analysis of single-cell genotypes revealed patient-specific clonal evolution and enabled the assessment of single-cell mutational cooccurrence. We discovered that changes in clonal architecture proceed via distinct patterns, classified as static or dynamic, with dynamic clonal architectures having a more proliferative phenotype by blast count fold change. Proteogenomic analysis of a subset of patients confirmed that pathogenic mutations were primarily confined to primitive and mature myeloid cells, though we also identify rare but present mutations in lymphocyte subsets. Single-cell transcriptomic analysis of paired sample sets further identified gene sets and signaling pathways involved in two cases of progression. Together, these data define serial changes in the MDS clonal landscape with clinical and therapeutic implications.Significance:Precise clonal trajectories in MDS progression are made possible by single-cell genomic sequencing. Here we use this technology to uncover the patterns of clonal architecture and clonal evolution that drive the transformation to secondary AML. We further define the phenotypic and transcriptional changes of disease progression at the single-cell level.See related article by Menssen et al., p. 330 (31).See related commentary by Romine and van Galen, p. 270.This article is highlighted in the In This Issue feature, p. 265
Vitamin D Enhances Hematoma Clearance and Neurologic Recovery in Intracerebral Hemorrhage
Authors: Liu Jiaxin , Li Ning , Zhu Zhiyuan , Kiang Karrie Mei-Yee , Ng Anson Cho Kiu , Dong Celia M. , Leung Gilberto Ka-Kit 
Published: May 2022

Background:
Erythrophagocytosis by reparative monocyte-derived macrophage contributes to hematoma clearance and neurological recovery after intracerebral hemorrhage (ICH). Vitamin D (VitD) is a neuroprotective hormone and regulates the differentiation of monocyte-derived macrophage from monocytes. In this study, we examined the effects of VitD supplementation on monocyte-derived macrophage and hematoma clearance in rodent with ICH.

Methods:
Neurobehavioral functions and hematoma volume were assessed using a collagenase injection model in both young- and middle-aged mice with or without VitD treatment given 2 hours post-ICH induction. We used flow cytometry to analyze CD36 expression and macrophage and undifferentiated monocyte cell numbers during in vivo erythrophagocytosis in collagenase and autologous blood injection models. Western blot analysis and immunofluorescence were used to assess the expression levels of the PPAR-γ (peroxisome proliferator-activated receptor γ)-CD36 axis and CD206. A macrophage differentiation study was conducted on murine bone marrow-derived monocytes.

Results:
VitD promoted neurological recovery and facilitated hematoma clearance in both young- and middle-aged mice after ICH. Within the perihematomal region, mature macrophages, rather than undifferentiated monocytes, expressed higher levels of CD36 in driving erythrocyte clearance. VitD increased the macrophage number but decreased the monocyte number and elevated the levels of CD36 and PPAR-γ in the brain. In vitro, VitD accelerated the differentiation of reparative macrophages from bone marrow-derived monocytes.

Conclusions:
VitD promotes reparative macrophage differentiation, facilitates hematoma clearance, and improves neurobehavioral performance in mice with ICH, suggesting that VitD should be further examined as a potentially promising treatment for ICH.
Perceptions of White-Collar Crime Seriousness: Unpacking and Translating Attitudes into Policy Preferences
Authors: Simpson Sally S. , Galvin Miranda A. , Loughran Thomas A. , Cohen Mark A. 
Published: May 2022

Objectives Test the role of individual and crime characteristics on public opinions of white-collar crime seriousness and support for crime reduction policy; consider the relationship between perceptions of crime seriousness and support for public policies to reduce white-collar crime. Methods Data from a nationally-representative survey. Respondents ( n = 2,050) rated ten white-collar crimes, relative to a street crime (burglary) and also indicated their relative support (i.e., willingness to pay) for 16 policies to reduce various types of white-collar crime. Models incorporate respondent-level random effects to account for multiple ratings per respondent. Results Crimes committed by organizations are perceived more seriously than those committed by individuals. Perceptions of a white-collar crime as more serious than burglary increase the likelihood of supporting prevention programs. Race and political party are related to both perceptions of crime seriousness and support for prevention policy. Conclusions There may be less consensus around perceptions of white-collar crime seriousness than for other crime types. Perceptions of crime seriousness are a function of both individual and crime characteristics that structure assessments of risk, harmfulness, and wrongfulness. Group differences may be related to differences in awareness of the scope, harms, and perceived victimization risk associated with particular crime types.
Delivery of Distance Counselling to Survivors of Sexual Violence: A Scoping Review of Promising and Best Practices
Authors: Leroux Janette , Johnston Natalie , Brown Ashley-Anne , Mihic Alanna , DuBois Denise , Trudell AnnaLise 
Published: May 2022

Distance counselling holds immense potential for improving access to trauma supports for survivors of sexual violence (SV), and particularly for under-served groups who disproportionately experience violence and myriad barriers to accessing in-person supports. And yet, the evidence-base for the practice and delivery of distance counselling remains under-developed. In the context of COVID-19, where telehealth applications have undergone a rapid uptake, we undertook a scoping review of existing evidence of therapeutic and organizational practices related to the real-time (synchronous) delivery of distance counselling to survivors of SV. We based our scoping review methods on Arksey and O’Malley framework and in accordance with the guidance on scoping reviews from the Joanna Briggs Institute (JBI) and PRISMA reporting guidelines for scoping reviews. A comprehensive search of MEDLINE, Embase, PsycINFO, CINAHL, Web of Science, and Sociological Abstracts was undertaken in October 2020, and again in March 2022. Searching, reviewing, appraisal, and data extraction was undertaken by two reviewers. In total, 1094 records were identified that resulted in 20 studies included. Descriptions, findings, and recommendations were gleaned and synthesized into potential practices using inductive thematic analysis. While many studies have an appreciative orientation to distance counselling, these benefits tend to be framed as non-universal, and conditional on survivor safety, flexibility, anonymity, survivor choice, strong and inclusive technology, and a supported workforce. Despite the limited evidence-base, we present several clusters of findings that, taken together, can be used to support current COVID-19 distance counselling initiatives with survivors, as well as guide the future development of best practices.
Deficit-Oriented Beliefs, Anti-Black Policies, Punitive Practices, and Labeling: Exploring the Mechanisms of Disproportionality and Its Impact on Black Boys in One Urban “No-Excuses” Charter School
Authors: Marsh L. Trenton S. , Walker Larry J. 
Published: May 2022

Background/Context: Embedded in “common sense” and state-mandated reforms to close “the achievement gap,” the urban school, especially those sites with a no-excuses orientation to learning, can produce and reproduce the carceral state in students’ lives. The seemingly innocuous policies and processes limit access to educational opportunities and create disproportionate out-of-class time, which can emerge as the connective tissue for criminalization and the school-to-prison nexus that disproportionately affects Black males in the United States. Purpose/Objective/Research Question/Focus of Study: The objective of the study was to illuminate the more unspoken mechanisms of disproportionality in school while concurrently raising awareness of how everyday practices, like school-imposed mis/labeling, contribute to the symbolic violence and dehumanization of Black and Latinx boys in school. Research Design: The article includes purposeful observations and semi-structured interview data with school personnel and students drawn from a 14-month ethnographic study. Findings/Results: The findings from this study revealed that the mechanisms of disproportionality ranged from explicit anti-Black policies to more tacit systems and processes, but all reflected how the no-excuses environment contributes to the connective tissue of criminalization and the school-to-prison nexus for boys of Color. The finding centers on three systems and policies that are influenced by carceral logic and the enforcement of student alienation. Conclusion/Recommendations: The findings from the study reveal the need for a radical transformation of no-excuses public charter schools, one that is community-based and rooted in an Afrocentric education. If educators and other school personnel are working in tandem with community members, they can reassess their negative misperceptions of minoritized communities that begin to shape infractions rooted in anti-Blackness. A community-based approach can begin to dismantle the school-to-prison nexus. Furthermore, an Afrocentric education approach requires school personnel to understand the history and culture of people of African descent and to see students’ full humanity. Here, students’ lived experiences would be centered within the diaspora, while sociocultural norms that may have been criminalized in the past would be valued and accepted.
Safety and effectiveness of simultaneous localization of multiple lung nodules using coils and risk factors for pneumothorax: a retrospective study
Authors: Ai Min 
Published: May 2022

Background Localization of lung nodule before video-assisted thoracoscopic surgery (VATS) can help the surgeon to quickly and accurately find the lesion during surgery. Purpose To evaluate the safety and effectiveness of using coils to simultaneously locate multiple lung nodules under computed tomography guidance and to clarify the risk factors for pneumothorax. Material and Methods From January 2020 to December 2020, 61 patients underwent simultaneous localization of multiple lung nodules (Group A) and 120 patients underwent localization of a single lung nodule (Group B). The demographics, information related to localization procedure, and incidence of pulmonary hemorrhage and pneumothorax were compared between the patients in Groups A and B. Group A was further divided into a pneumothorax group and non-pneumothorax group. Univariate and multivariate regression analyses were used to determine the risk factors for pneumothorax in patients who underwent simultaneous localization of multiple lung nodules using coils. Results The success rates in Groups A and B were 96.9% and 96.7%, respectively (P = 1.000). The number of pleural punctures ( P<0.001), the positioning operation time ( P<0.001), the rates of pneumothorax ( P<0.001), and hemorrhage ( P = 0.034) were higher in Group A than in Group B. The pneumothorax and bleeding in Group A did not require special treatment. Transfissural puncture (odds ratio [OR]=16.798; P = 0.033) and the numbers of pleural punctures (OR=2.437; P = 0.013) were independent risk factors for pneumothorax caused by simultaneous localization of multiple lung nodules, and hemorrhage was a protective factor against pneumothorax (OR=0.069; P = 0.002). Conclusion Simultaneous localization of multiple lung nodules using coils under computed tomography guidance is safe and effective. Transfissural puncture and higher numbers of pleural punctures will increase the risk of pneumothorax, whereas hemorrhage will reduce the risk of pneumothorax.
Timing of headache after COVID-19 vaccines and its association with cerebrovascular events: An analysis of 41,700 VAERS reports
Authors: Garcia-Azorin David , Baykan Betül , Beghi Ettore , Doheim Mohamed F , Fernandez-de-las-Penas Cesar , Gezegen Hasim , Guekht Alla , Hoo Fan Kee , Santacatterina Michele , Sejvar James , Tamborska Arina A , Thakur Kiran T , Westenberg Erica , Winkler Andrea S , Frontera Jennifer A ,   Contributors from the Global COVID-19 Neuro Research Coalition
Published: May 2022

Background Delayed-onset of headache seems a specific feature of cerebrovascular events after COVID-19 vaccines. Methods All consecutive events reported to the United States Vaccine Adverse Reporting System following COVID-19 vaccines (1 January to 24 June 2021), were assessed. The timing of headache onset post-vaccination in subjects with and without concomitant cerebrovascular events, including cerebral venous thrombosis, ischemic stroke, and intracranial haemorrhage was analysed. The diagnostic accuracy in predicting concurrent cerebrovascular events of the guideline- proposed threshold of three-days from vaccination to headache onset was evaluated. Results There were 314,610 events following 306,907,697 COVID-19 vaccine doses, including 41,700 headaches, and 178/41,700 (0.4%) cerebrovascular events. The median time between the vaccination and the headache onset was shorter in isolated headache (1 day vs. 4 (in cerebral venous thrombosis), 3 (in ischemic stroke), or 10 (in intracranial hemorrhage) days, all P < 0.001). Delayed onset of headache had an area under the curve of 0.83 (95% CI: 0.75–0.97) for cerebral venous thrombosis, 0.70 (95% CI: 0.63–76) for ischemic stroke and 0.76 (95% CI: 0.67–84) for intracranial hemorrhage, and >99% negative predictive value. Conclusion Headache following COVID-19 vaccination occurs within 1 day and is rarely associated with cerebrovascular events. Delayed onset of headache 3 days post-vaccination was an accurate diagnostic biomarker for the occurrence of a concomitant cerebrovascular events.
Blue-Light Therapy for Seasonal and Non-Seasonal Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Do André , Li Victor W. , Huang Samantha , Michalak Erin E. , Tam Edwin M. , Chakrabarty Trisha , Yatham Lakshmi N. , Lam Raymond W. 
Published: May 2022

Objectives To determine the efficacy and safety of blue-light therapy in seasonal and non-seasonal major depressive disorder (MDD), by comparison to active and inactive control conditions. Methods We searched Web of Science, EMBASE, Medline, PsycInfo, and Clinicaltrials.gov through January 17, 2022, for randomized controlled trials (RCTs) using search terms for blue/blue-enhanced, light therapy, and depression/seasonal affective disorder. Two independent reviewers extracted data. The primary outcome was the difference in endpoint scores on the Structured Interview Guide for the Hamilton Depression Rating Scale - Seasonal Affective Disorder (SIGH-SAD) or the Structured Interview Guide for the Hamilton Depression Rating Scale with Atypical Depression Supplement (SIGH-ADS) between blue light and comparison conditions. Secondary outcomes were response (≥ 50% improvement from baseline to endpoint on a depression scale) and remission rates (endpoint score in the remission range). Results Of 582 articles retrieved, we included nine RCTs ( n = 347 participants) assessing blue-light therapy. Seven studies had participants with seasonal MDD and two studies included participants with non-seasonal MDD. Four studies compared blue light to an inactive light condition (efficacy studies), and five studies compared it to an active condition (comparison studies). For the primary outcome, a meta-analysis with random-effects models found no evidence for the efficacy of blue-light conditions compared to inactive conditions (mean difference [MD] = 2.43; 95% confidence interval [CI], −1.28 to 6.14, P = 0.20); however, blue-light also showed no differences compared to active conditions (MD = −0.11; 95% CI, −2.38 to 2.16, P = 0.93). There were no significant differences in response and remission rates between blue-light conditions and inactive or active light conditions. Blue-light therapy was overall well-tolerated. Conclusions The efficacy of blue-light therapy in the treatment of seasonal and non-seasonal MDD remains unproven. Future trials should be of longer duration, include larger sample sizes, and attempt to better standardize the parameters of light therapy.