bluuebunny/crossref_metadata_2025_split huggingface dataset:
MEDIA INFORMASI PENGAJIAN MAJLIS TAKLIM DI KECAMATAN KERTAJATI BERBASIS WEB
Authors: Salahuddin nurul fahmi  
Published: December 2022

Media Information in general is a tool for collecting and rearranging information so that it becomes useful material for recipients of information. Majelis taklim is one of the non-formal diniyah educational institutions that aims to increase faith and piety to Allah SWT and noble character for its congregations, as well as to realize mercy for the universe. Majlis taklim recitations are often held in the Kertajati sub-district, but many people in Kertajati do not know the schedule for the recitation of the Majlis because the delivery is only by word of mouth, therefore the impact of ignorance is only the people around the recitation place who follow it so that the presence of the congregation 'ah not optimal. So that the Information Media for the Majlis Taklim Recitation was made. With this system, it is expected to provide an online recitation schedule information feature, which can make it easier for the public to find the location of the recitation to be held. This system is made using CodeIgniter while for system development using the Waterfall Method.

Keywords : Information Media, Majlis Taklim, Recitation, CodeIgniter, Waterfall.
آثار التنمر المدرسي على ضحايا التنمر من وجهة نظر المعلمين وسبل مواجهتها
Authors: Al-dhuhoori Khadija Ali , Yaiche Ouassila 
Published: December 2022

هدفت الدراسة الحالية إلى التعرف على الآثار الاجتماعية والنفسية والتعليمية للتَّنّمُّر المدرسي على ضحايا التَّنّمُّر، وسبل الحد منها من وجهة نظر المعلمين بإمارة الشارقة. اعتمدت الدراسة على منهج المسح الاجتماعي، بأسلوب العينة العشوائية البسيطة، وبلغ عدد مفرداتها (100) من المعلمين والمعلمات العاملين بمدارس الشعلة الخاصة بإمارة الشارقة، وتم استخدام أداة الاستبانة لجمع المعلومات.
توصلت الدراسة إلى مجموعة من النتائج أهمها:
جاءت الآثار الاجتماعية للتنمر المدرسي على ضحايا التَّنّمُّر بالمرتبة الأولى بمتوسط حسابي قدره (2.62)، وأبرزها: افتقار ضحايا التَّنّمُّر إلى مهارة التواصل الاجتماعي مع الآخرين، وقصورهم في الحصول على الدعم الاجتماعي. تلتها الآثار النفسية بمتوسط حسابي قدره (2.60)، وأبرزها: صعوبة الدفاع عن النفس؛ الميل إلى العزلة والانطوائية، ضعف الثقة بالنفس، وانخفاض تقدير الذات. فيما جاءت الآثار التعليمية في المرتبة الثالثة بمتوسط حسابي قدره (2.51)، وأبرزها: انخفاض التحصيل الدراسي، صعوبة التركيز أثناء شرح المعلمين، والانسحاب من الأنشطة اللاصفية.
تمثلت سبل المواجهة المقترحة من طرف المعلمين للحد من ظاهرة التَّنّمُّر المدرسي في: اشراك ضحايا التنمر بالأنشطة اللاصفية والأعمال التطوعية، تعزيز دور الأخصائيين الاجتماعيين والنفسيين بالمدارس، وعقد اللقاءات والمناقشات التوعوية بين إدارة المدرسة وأولياء أمور الطلبة.
تداعيات الظلم العباسي على التحرك العلوي
Authors: Al-Kaabi Rahim Sabah Baheen Mohammed , Al-Ahmadi Qasim 
Published: December 2022

عنوان المقالة «تداعيات الظلم العباسي على التحرك العلوي» هذا العنوان يعبّر عن موقف العباسيين تجاه العلويين، وخصوصا اهل بيت العصمة والطهارة (عليهم السلام) يقوده في ذلك الحقد الدفين والحسد المقيت لما نالته العترة الطاهرة (عليهم السلام) من مكانة إلهية ومنزلة ربانية، ولذلك افرز عداوة وقتلا وانتهاكاً، ضمن مخطط فيه الكثير من المكر والدهاء وعدم خشيه من الله تعالى، بالرغم من ان نجاح حركتهم وقيام دولتهم كان مرتكزاً وبشكل اساسي على ربطها باهل البيت (عليهم السلام).
الدافع لاختيار هذا الموضوع: هو الكشف عن عمق الاجراءات الفكرية والاجتماعية والسياسية، وتحليلها على أساس المعايير الإلهية.
والمشكلة في هذا البحث تتمثل في سعة الموضوع ودقّته وحساسيته.
ـكما أن أهمية الموضوع تركزت في بيان حقيقة العداء العباسي لأهل البيت (عليهم السلام).
ـوأهم أهداف البحث هو بيان حجم جريمة المواجهة تجاه العلويين، وخلفيات ذلك التوجه.
ـأن أبرز فرضيات البحث كانت في بيان الحقد الدفين والدوافع الذاتية والسلطوية التي نسجت خيوط المواجهة.
ـواقع ومجتمع البحث هو الدولة العباسية، ومواجهتها لأهل البيت (عليهم السلام).
اعتمدنا على جملة كبيرة من المصادر، إضافة إلى البحث والسؤال من أساتذة التاريخ في الحوزة العلمية، واستفدنا من الدراسات السابقة لهذا الموضوع.
وأهم النتائج هي توسعة الدراسات التي تعنى بالحياة الفكرية والسياسية لأهل البيت (عليهم السلام).
أوصي بدراسة التاريخ دراسة معمقة خصوصاً علاقة الحكام الإسلاميين مع أهل بيت العصمة والطهارة (عليهم السلام).
Penerapan Rebusan Air Daun Binahong Untuk Mempercepat Penyembuhan Luka Perineum Pada Ibu Post Partum
Authors: S Susanti , Yamin M , Nurcahyani Azizah 
Published: December 2022

The World Health Organization (WHO), reports that as many 25% of MMR occur due to post partum problems.The direct factor causing the high AKI is post partum hemorrhage (45%). Post partum is the postpartum period which starts from the time the baby is born and the placenta of the baby is born so that the womb returns to what it was before pregnancy which lasts for six weeks. Post partum hemorrhage due to the opening of blood vessels in the uterus during pregnancy due to the perineal wound can cause infection, Non-pharmacological management that can be given to accelerate the healing of perineal wounds is to use binahong leaf water boiled. To find out the application of giving binahong leaf water boiled to accelerate the healing of perineal wounds in post partum mothers. This study uses a literature review study that uses literature sources in the form of books, scientific articles, especially those that have been published. By using a search through the Google Scholar database from 2015-2020. Research result Shows that there is a significant effect on the application of giving binahong leaf water boiled to accelerate the healing of perineal wounds in post partum mothers. The application of boiled water from binahong leaves is more effective in accelerating the healing of perineal wounds in post partum mothers.
Contribuição à História da Prevenção do Câncer no Instituto Nacional de Câncer
Authors: Carvalho Alexandre Octavio Ribeiro de , Almeida Liz Maria de , Franco Eduardo Barros 
Published: December 2022

A partir da década de 1980, no contexto da redemocratização, e da adoção de políticas restritivas de gastos, o Instituto Nacional de Câncer passou a coordenar a Política Nacional de Prevenção e Controle do Câncer, construindo uma agenda para prevenção do câncer, coordenada, cronologicamente, pelo Programa de Oncologia (Pro-Onco) (1988-1996), e seus sucessores, Coordenação Nacional de Tabagismo e Prevenção Primária (Contapp) (1996-1998), e a atual Coordenação de Prevenção e Vigilância (Conprev) (desde o final de 1998 até o presente).
Factor Affecting Treatment Compliance in TB Patients
Authors: Lucya Vita , Arief Nabila Triefitriani 
Published: December 2022

Aims: Pulmonary Tuberculosis is a disease caused by Mycobacterium tuberculosis that invades the lungs. Indonesia ranks second as the country with the highest number of pulmonary TB in the world. The treatment coverage of Pulmonary TB in Indonesia in 2022 is only 25% of the target (80%). One of the risk factors that cause treatment failure is medication adherence.
Objective: This study aims to determine the factors that influence medication adherence in patients with pulmonary TB.
Methods: This study used a quantitative descriptive design with a cross-sectional study on 33 patients with pulmonary TB who became respondents by using total sampling. This study uses more than one instrument including Morisky Medication Adherence Scale-8, Generic Assessment of Side Effects, Multidimensional Scale of Perceived Social Support. The data analysis that were used in this study are Pearson Product Moment, Chi-square, Kruskal-wallis, and Simple Linear Regression.
Results: The results of this study on factors related to medication adherence on TB patients showed that age, level of education, duration of treatment, drug side effects, and family support were related to medication adherence of pulmonary TB patients. alone.
Conclusion: This study showed that to achieve medication adherence requires the continuity of various factors and does not depend on one factor Future researchers are expected to examine other factors that can affect medication adherence in patients with Pulmonary TB.
Small intestinal submucosa-derived extracellular matrix as a heterotopic scaffold for cardiovascular applications
Authors: Palmosi Tiziana , Tolomeo Anna Maria , Cirillo Carmine , Sandrin Debora , Sciro Manuela , Negrisolo Susanna , Todesco Martina , Caicci Federico , Santoro Michele , Dal Lago Eleonora , Marchesan Massimo , Modesti Michele , Bagno Andrea , Romanato Filippo , Grumati Paolo , Fabozzo Assunta , Gerosa Gino 
Published: December 2022

Structural cardiac lesions are often surgically repaired using prosthetic patches, which can be biological or synthetic. In the current clinical scenario, biological patches derived from the decellularization of a xenogeneic scaffold are gaining more interest as they maintain the natural architecture of the extracellular matrix (ECM) after the removal of the native cells and remnants. Once implanted in the host, these patches can induce tissue regeneration and repair, encouraging angiogenesis, migration, proliferation, and host cell differentiation. Lastly, decellularized xenogeneic patches undergo cell repopulation, thus reducing host immuno-mediated response against the graft and preventing device failure. Porcine small intestinal submucosa (pSIS) showed such properties in alternative clinical scenarios. Specifically, the US FDA approved its use in humans for urogenital procedures such as hernia repair, cystoplasties, ureteral reconstructions, stress incontinence, Peyronie’s disease, penile chordee, and even urethral reconstruction for hypospadias and strictures. In addition, it has also been successfully used for skeletal muscle tissue reconstruction in young patients. However, for cardiovascular applications, the results are controversial. In this study, we aimed to validate our decellularization protocol for SIS, which is based on the use of Tergitol 15 S 9, by comparing it to our previous and efficient method (Triton X 100), which is not more available in the market. For both treatments, we evaluated the preservation of the ECM ultrastructure, biomechanical features, biocompatibility, and final bioinductive capabilities. The overall analysis shows that the SIS tissue is macroscopically distinguishable into two regions, one smooth and one wrinkle, equivalent to the ultrastructure and biochemical and proteomic profile. Furthermore, Tergitol 15 S 9 treatment does not modify tissue biomechanics, resulting in comparable to the native one and confirming the superior preservation of the collagen fibers. In summary, the present study showed that the SIS decellularized with Tergitol 15 S 9 guarantees higher performances, compared to the Triton X 100 method, in all the explored fields and for both SIS regions: smooth and wrinkle.
How to promote STEM competencies through design
Authors: Nichols Kim , Musofer Reshma , Haynes Michele 
Published: December 2022

IntroductionThis study explored the impact of a community of inquiry on Science, Design and Technology and Mathematics curriculum competencies of 159 Year six students as they carried out a design task.MethodsA quasi-experimental design was employed with both qualitative and quantitative analyses. A community of inquiry approach was adopted by the teachers (n = 3) in the experimental group but not by teachers (n = 4) in the comparison group. Both groups participated in a learning sequence on electricity culminating in a design challenge in small collaborative groups.ResultsThe results showed that the experimental group (n = 65) demonstrated significantly greater instances and a broader range of Science, Design and Technology and Mathematics competencies across the design task as well as significantly higher learning gains than their comparison group (n = 94) peers.DiscussionThe cognitive shifts towards higher competency development in the experimental group is stronger as a result of the reflection and reasoning required to engage in a community of inquiry.
The role of advanced glycation end products in fracture risk assessment in postmenopausal type 2 diabetic patients
Authors: Gao Liu , Liu Chang , Hu Pan , Wang Na , Bao Xiaoxue , Wang Bin , Wang Ke , Li Yukun , Xue Peng 
Published: December 2022

ObjectiveThe objective of this study was to analyze the quantitative association between advanced glycation end products (AGEs) and adjusted FRAX by rheumatoid arthritis (FRAX-RA) in postmenopausal type 2 diabetic (T2D) patients. The optimal cutoff value of AGEs was also explored, which was aimed at demonstrating the potential value of AGEs on evaluating osteoporotic fracture risk in postmenopausal T2D patients.MethodsWe conducted a cross-sectional study including 366 postmenopausal participants (180 T2D patients [DM group] and 186 non-T2D individuals [NDM group]). All the subjects in each group were divided into three subgroups according to BMD. Physical examination, dual-energy x-ray absorptiometry (DXA), and serum indicators (including serum AGEs, glycemic parameters, bone turnover markers and inflammation factors) were examined. The relationship between FRAX-RA, serum laboratory variables, and AGEs were explored. The optimal cutoff value of AGEs to predict the risk of osteoporotic fracture was also investigated.ResultsAdjusting the FRAX values with rheumatoid arthritis (RA) of T2D patients reached a significantly increased MOF-RA and an increasing trend of HF-RA. AGEs level was higher in the DM group compared to the NDMs, and was positively correlated with MOF-RA (r=0.682, P&lt;0.001) and HF-RA (r=0.677, P&lt;0.001). The receiver operating characteristic curve analysis revealed that the area under the curve was 0.804 (P&lt;0.001), and the optimal AGEs cut-off value was 4.156mmol/L. Subgroup analysis for T2D patients revealed an increase in TGF-β, IL-6 and SCTX in the osteoporosis group, while a decreased PINP in the osteoporosis group compared to the other two subgroups. AGEs were positively associated with FBG, HbA1c, HOMA-IR, S-CTX, IL-6 and TGF-β in T2D patients, and negatively associated with PINP.ConclusionsRA-adjusted FRAX is a relevant clinical tool in evaluating fracture risk of postmenopausal T2D patients. Our study analyzed the relationship between AGEs and FRAX-RA, and explored the threshold value of AGEs for predicting fracture risk in postmenopausal T2D patients. AGEs were also associated with serum bone turnover markers and inflammation factors, indicating that the increasing level of AGEs in postmenopausal T2D patients accelerated the expression of inflammatory factors, which led to bone metabolism disorders and a higher risk of osteoporotic fractures.
Hypoxanthine guanine phosphoribosyl transferases SmHGPRTases functional roles in Schistosoma mansoni
Authors: Batista Izabella Cristina Andrade , Gava Sandra Grossi , Tavares Naiara Clemente , Calzavara-Silva Carlos Eduardo , Mourão Marina Moraes 
Published: December 2022

IntroductionExtracellular/environmental stimuli trigger cellular responses to allow Schistosoma sp. parasites adaptation and decide development and survival fate. In this context, signal transduction involving eukaryotic protein kinases (ePKs) has an essential role in regulatory mechanisms. Functional studies had shown the importance of MAPK pathway for Schistosoma mansoni development. In addition, early studies demonstrated that Smp38 MAPK regulates the expression of a large set of genes, among them the hypoxanthine-guanine phosphoribosyl transferase 1 (SmHGPRTase 1, Smp_103560), a key enzyme in the purine salvage pathway that is part of a family comprising five different proteins.MethodsFirst, the regulation of this gene family by the MAPKs pathways was experimentally verified using Smp38-predicted specific inhibitors. In silico analysis showed significant differences in the predicted structure and the domain sequence among the schistosomal HGPRTase family and their orthologs in humans. In order to interrogate the HGPRTases (Smp_103560, Smp_148820, Smp_168500, Smp_312580 and Smp_332640, henceforth SmHGPRTase −1, −2, −3, −4, −5) functional roles, schistosomula, sporocysts, and adult worms were knocked-down using specific dsRNAs.ResultsOur results suggest that SmHGPRTases activity has an essential role in sporocysts and schistosomula development since significant differences in viability, size, and/ or shape were observed after the in vitro knockdown. Also, the knockdown of SmHGPRTases in schistosomula influenced the ovary development and egg maturation in female adult worms during mammalian infection. We also observed alterations in the movement of female adult worms knocked-down in vitro. Most of these results were shown when all gene family members were knocked-down simultaneously, suggesting a redundant function among them.DiscussionThus, this study helps to elucidate the functional roles of the SmHGPRTase gene family in the S. mansoni life cycle and provides knowledge for future studies required for schistosomiasis treatment and control.
DCE-MRI and DWI can differentiate benign from malignant prostate tumors when serum PSA is ≥10 ng/ml
Authors: Sun Hongmei , Du Fengli , Liu Yan , Li Qian , Liu Xinai , Wang Tongming 
Published: December 2022

BackgroundThis study investigated the diagnostic utility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) parameters for distinguishing between benign and malignant prostate tumors when serum prostate-specific antigen (PSA) level is ≥10 ng/ml.MethodsPatients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH) with serum PSA ≥10 ng/ml before treatment were recruited. Transrectal ultrasound-guided biopsy or surgery was performed for tumor classification and patients were stratified accordingly into PCa and BPH groups. Patients underwent DCE-MRI and DWI scanning and the transfer constant (Ktrans), rate constant (Kep), fractional volume of the extravascular extracellular space, plasma volume (Vp), and Prostate Imaging Reporting and Data System Version 2 (PI-RADS v2) score were determined. The apparent diffusion coefficient (ADC) was calculated from DWI. The diagnostic performance of these parameters was assessed by receiver operating characteristic (ROC) curve analysis, and those showing a significant difference between the PCa and BPH groups were combined into a multivariate logistic regression model for PCa diagnosis. Spearman’s correlation was used to analyze the relationship between Gleason score and imaging parameters.ResultsThe study enrolled 65 patients including 32 with PCa and 33 with BPH. Ktrans (P=0.006), Kep (P=0.001), and Vp (P=0.009) from DCE-MRI and ADC (P&lt;0.001) from DWI could distinguish between the 2 groups when PSA was ≥10 ng/ml. PI-RADS score (area under the ROC curve [AUC]=0.705), Ktrans (AUC=0.700), Kep (AUC=0.737), Vp (AUC=0.688), and ADC (AUC=0.999) showed high diagnostic performance for discriminating PCa from BPH. A combined model based on PI-RADS score, Ktrans, Kep, Vp, and ADC had a higher AUC (1.000), with a sensitivity of 0.998 and specificity of 0.999. Imaging markers showed no significant correlation with Gleason score in PCa.ConclusionDCE-MRI and DWI parameters can distinguish between benign and malignant prostate tumors in patients with serum PSA ≥10 ng/ml.
Do proton pump inhibitors affect the effectiveness of chemotherapy in colorectal cancer patients? A systematic review with meta-analysis
Authors: Lin Wan-Ying , Wang Shih-Syuan , Kang Yi-No , Porpiglia Andrea S. , Chang Yu , Huang Chin-Hsuan , Bhimani Ronak , Abdul-Lattif Eahab , Azmat Muneeba , Wang Tsu-Hsien , Lin Yu-Shiuan , Chang Yu-Cheng , Chi Kuan-Yu 
Published: December 2022

Proton pump inhibitors (PPI), one of the most commonly prescribed medications, carry a myriad of adverse events. For colorectal cancer (CRC) patients, it still remains unclear whether the concurrent use of proton pump inhibitors (PPI) would negatively affect chemotherapy. PubMed, Medline, Embase, and Cochrane Library were searched from inception to 10 June 2022, to identify relevant studies involving CRC patients receiving chemotherapy and reporting comparative survival outcomes between PPI users and non-users. Meta-analyses were performed using random-effects models. We identified 16 studies involving 8,188 patients (PPI = 1,789; non-PPI = 6,329) receiving either capecitabine-based or fluorouracil-based regimens. The overall survival (HR, 1.02; 95% CI, 0.91 to 1.15; I2 = 0%) and progression-free survival (HR, 1.15; 95% CI, 0.98 to 1.35; I2 = 29%) were similar between PPI users and non-users in patients taking capecitabine-based regimens, with low statis-tical heterogeneity. Although the subgroup analysis indicated that early-stage cancer patients taking capecitabine monotherapy with concurrent PPI had a significantly higher disease progression rate (HR, 1.96; 95% CI, 1.21 to 3.16; I2 = 0%) than those who did not use PPIs, both groups had comparable all-cause mortality (HR, 1.31; 95% CI, 0.75 to 2.29; I2 = 0%). On the other hand, there was little difference in both OS and PFS in both early- and end-stage patients taking capecitabine combination therapy between PPI users and non-users. Conversely, the use of concomitant PPI in patients taking fluorouracil-based regimens contributed to a marginally significant higher all-cause mortality (HR, 1.18; 95% CI, 1.00 to 1.40; I2 = 74%), but with high statistical heterogeneity. In conclusion, PPI has little survival influence on CRC patients treated with capecitabine-based regimens, especially in patients taking capecitabine combination therapy. Thus, it should be safe for clinicians to prescribe PPI in these patients. Although patients treated with fluorouracil-based regimens with concomitant PPI trended toward higher all-cause mortality, results were subject to considerable heterogeneity.Systematic Review Registration: identifier https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022338161
The impact financial resources on implementation of large-scale electronic health records in the Saudi Arabia's primary healthcare centers: Mixed methods
Authors: Alzghaibi Haitham , Mughal Yasir Hayat , Alkhamees Mohammad , Alasqah Ibrahim , Alhlayl Adel Sulaiman , Alwheeb Mohammed Hamed , Alrehiely Majedah 
Published: December 2022

IntroductionThere is worldwide demand for the implementation of electronic health systems and a transformation to electronic transactions in healthcare organizations. This move to e-health transformation stems from the perceived positive impact that e-health systems have in improving the quality of healthcare and, in turn, reducing expenses. Despite this, more than half of previous Electronic Health Record System (EHRS) implementation projects have failed due to several barriers and challenges such as cost.Aim of the studyTo evaluate the impact of financial resources (FR) on the implementation of the EHRS in PHCs in SA.MethodsA mixed methods approach was implemented. SPSS and AMOS-SEM are used to test reliability and validity and hypotheses. Thirty-one (59%) out of 51 policy makers at the MoH filled and returned the questionnaire while 13 policymakers were interviewed using semi-structure interviews.ResultsResults revealed that both measurement model and structural models met the threshold. All scales are found reliable and valid. Furthermore financial resources have positive impact on EHRS implementation. Findings from both studies show that financial resources have a very positive impact to facilitate large-scale EHRs implementation and overcome barriers that may lead to the failure of the project.