bluuebunny/crossref_metadata_2025_split huggingface dataset:
Italian validation of the Guilt And Shame Proneness Scale: preliminary results
Authors: Faccini F. , Rogier G. , Cavalli R. , Velotti P. 
Published: September 2022

IntroductionBackground: Recently, a new instrument, the Guilt And Shame Proneness Scale has been developed and showed promising psychometric properties. However, the Italian version of the Instrument has not still been validated. In addition, despite the growing number of studies on the topic, the knowledge regarding the role played by guilt, shame and rivalry in the relationship between pathological narcissism facets and suicidal ideation.ObjectivesTo validate the Italian version of the Guilt And Shame Proneness Scale and to extend the knowledge regarding the relationships between guilt, shame, pathological narcissism and suicidality.MethodsWe administrated, to a sample of Italian adults, the Italian versions of the GASP, the Pathological Narcissism Inventory, the Beck Suicide Inventory and the Narcissism Admiration and Rivalry Questionnaire.ResultsThe structural equation model testing the factorial structure of the Italian version of the GASP obtained a good fit. In addition, invariance among gender as well as other invariance tests were tested successfully. Finally, regression and mediation analyses showed that the subscale Shame Social withdraw mediate the relationship between Narcissism grandiosity and suicidal ideation. In contrast, rivalry and social withdraw in response to shame were no more predictive of suicidal ideation controlling for pathological narcissism levels.ConclusionsThe Italian version of the GASP appears promising to deepen the investigation of the pathological personality topic.DisclosureNo significant relationships.
Childbirth hospitalizations in Bipolar disorder patients: a nationwide study protocol
Authors: Araújo G. , Gonçalves-Pinho M. , Ferreira A.R. , Fernandes L. , Freitas A. 
Published: September 2022

IntroductionBipolar disorder (BD) is usually diagnosed in adulthood, around childbearing age. Research has shown that BD has deleterious effects on pregnant women and birth outcomes. However, few nationwide studies using administrative data have approached this at-risk population focusing specifically on childbirth.ObjectivesThis study aims to characterize hospitalizations of women with BD in the peripartum period regarding sociodemographic and clinical variables and to investigate the impact BD has on hospitalization outcomes.MethodsAn observational retrospective study will be performed using an administrative database that comprises routinely collected hospitalization data from all mainland Portuguese public hospitals. International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes will be used to identify all women’s admissions for childbirth purposes (V27.X) and codes 296.XX (except 296.2X, 296.3X, 296.9X) will be used to ascertain BD. Episodes will be assigned to one of two mutually exclusive groups (with vs without BD). Multivariate methods will be used to compare both groups concerning key variables and outcomes. This work will comply with the RECORD statement recommendations.ResultsDescriptive and analytical statistics will be conducted in order to describe and characterize this group of patients. Results will be presented as crude and adjusted odds ratio quantifying the risk associated with BD in pregnancy, childbirth and hospitalization outcomes. Findings will be disseminated via publication in peer-reviewed journals.ConclusionsWith this nationwide analysis, we expect to contribute to a better understanding of the demographic and clinical profile of pregnant women with BD and to encourage timely medical and psychological interventions during gestation and childbirth.DisclosureNo significant relationships.
Finishing General and Adult Psychiatric Training During COVID-19 and Getting Prepared to Become a Post-Pandemic Psychiatrist in Central Europe
Authors: Zaja N. , Seker A. 
Published: September 2022

The ongoing pandemic has brought many changes to the lives of almost all people around the world. Medical professionals have also experienced significant changes at their workplace, with many of them engaged in treating COVID-19 patients instead of working in a field of medicine they have trained to work in. Trainees of all medical specialities have often been the first ones to join the effort in combating the pandemic and psychiatric trainees were no exception. The pandemic has brought their training to a halt and the majority of psychiatric educational activities have initially been postponed or canceled, with clinical rotations between different institutions almost non-existent. In a search for more space to treat COVID-19 patients, psychiatric wards were often the first ones to be repurposed. Epidemiological measures have lowered the number of patients a trainee could see each day and have also made clinical supervision less available. However, the introduction of online communication platforms as a new standard of interaction has helped mitigate many of the issues and enabled resuming most of the educational activities. Since trainees were usually more experienced in online communication than senior doctors, their skills were very valuable in establishing telepsychiatric services. Even though the pandemic has created many obstacles in psychiatric training, it has also proved that training is very much about learning and implementing new skills, as well as adapting to new circumstances.DisclosureNo significant relationships.
The effect of intranasal oxytocin application and mindfulness-based group therapy for patients with schizophrenia spectrum disorders – A study protocol
Authors: Zierhut M. , Von Eisenhart-Rothe V. , Graesser S. , Hartter N. , Wohlthan J. , Hahne I. , Bergmann N. , Ta T.M.T. , Bajbouj M. , Hahn E. , Boege K. 
Published: September 2022

IntroductionResearch indicates improvements in negative symptoms and empathy for schizophrenia spectrum disorders (SSD) after mindfulness-based interventions (MBI). Current treatment approaches for SSD remain limited regarding their effectiveness on negative symptoms and sociocognitive deficits. After oxytocin (OXT) administration, especially in a positive social context, an increase in empathy could be shown. The effect of mindfulness in combination with OXT has not yet been examined.ObjectivesThis study investigates the additional effect of OXT administration combined with MBI on empathy and negative symptoms in patients with SSD.MethodsAn experimental, randomised, triple-blinded, placebo-controlled study is proposed. Based on power calculations, 140 participants with SSD will be recruited at Charité – Universitätsmedizin Berlin. A dose of intranasal oxytocin with 24 I.U. or placebo will be administered 45 minutes before each session. Following each administration, a total of four MBI interventions will take place for two weeks. Empathy as primary outcome will be measured using validated psychometric questionnaires. Outcomes, including negative symptoms and OXT plasma levels, will be measured at baseline and post-intervention. A 2x2 mixed-model ANCOVA design with time as within- and group as between-subject factor will be calculated to assess empathy and negative symptom changes.ResultsThe study hypothesises that applying intranasal oxytocin in combination with MBI will increase empathy and reduce negative symptoms in patients with SSD.ConclusionsFindings could provide insight into enhancing therapies like MBI by utilising OXT as a possible supplementary treatment option. Findings could therefore pave the way for a personalised psychiatric medicine treatment for individuals with SSD.DisclosureNo significant relationships.
A Link Between Gut Microbiota and Schizophrenia
Authors: Sá Couto J. , Pão Trigo M. , Da Luz B. , Rodrigues J. , Ventura Gil T. 
Published: September 2022

IntroductionMicroorganisms distributed in our tissues and fluids make up the human microbiota. During our lifetime, gastrointestinal microbiota acts as an important modulator of brain development and, in turn, adult behavior and health. Immune response may be triggered by gut microbiota, releasing mediators that penetrate the blood-brain barrier (BBB).ObjectivesUnderstanding if gut microbiota can influence schizophrenia pathogenesis. Clarifying how gut microbiota can influence schizophrenia treatment, and vice-versa.MethodsPubMed database search, with “gut microbiota and schizophrenia” keyword expression. Eight articles published in the last ten years were selected among the most recent best match results. Reference lists of articles were reviewed to identify additional articles.ResultsThere could be an association between the development of gut microbiota starting during pregnancy and schizophrenia pathogenesis, through an immune-mediated process. Schwarz et al. (2018) investigated the differences in faecal microbiota between individuals with first-episode psychosis and controls. They found psychotic patients to have an increased amount of Lactobacillus bacteria. Yuan et al. (2018) studied microbiota changes in patients with schizophrenia, before and after treatment. Individuals diagnosed with schizophrenia had less faecal Bifidobacterium, Escherichia coli and Lactobacillus. After treatment with risperidone, there was a significant increase in the amount of fecal Bifidobacterium and E. Coli.ConclusionsMicroorganisms living inside our gastrointestinal tract are vital for proper central nervous system (CNS) development. Patients with schizophrenia have anomalies in the composition of the microbiota. It remains unclear if microbiota changes after treatment further influence the course of the disease.DisclosureNo significant relationships.
Polypharmacy and relapse of schizophrenia: are they related?
Authors: Softic R. , Osmanovic S. , Becarevic N. 
Published: September 2022

IntroductionPolypharmacy can be the cause of deliberate discontinuation of medication and consequent relapse of schizophrenia.ObjectivesTo establish the one-year rate of relapse in the patients with schizophrenia with regard to monotherapy or polypharmacy.MethodsThe sample of all hospitalized patients with schizophrenia in a five-year period was analyzed. Descriptive statistics were used.ResultsTotal of 87 participants (57 women), the median age was 43 years. Antipsychotic monotherapy was used in 31 (35.6%) of the participants. In one year period, 32 (36.8%) of all participants had a relapse. Prior to relapse, significantly more participants were treated with polypharmacy (p<0,05).ConclusionsAntipsychotic polypharmacy is related to a higher rate of relapse in patients with schizophrenia.DisclosureNo significant relationships.
Self-perceived functional impairment or disability in Delusional Disorder – Case Reports
Authors: Basto M.D.R.D.R.F.D. , Certo A. , Nombora O. , Horta A. , Mendes E. , Venâncio Â. 
Published: September 2022

IntroductionDelusional disorder (DD) is a psychotic disorder with an estimated prevalence of less than one percent,traditionally characterized by systematized delusional ideas with no cognitive deterioration.However, some studies have been reporting impairment of neurocognitive system (social cognition,learning and memory, expressive language,complex attention, executive function) that might have an impact functionality both in social and work domains..ObjectivesThis work aims to review clinical evidence on self-perceived functional impairment or disability in DD and to present two clinical cases evaluated at a psychiatric unit.MethodsWe report two clinical cases based on patients’ history and clinical data, and reviewed clinical records using PubMed® database with search terms of “Delusional Disorder”,“Cognition Impairment in Persistent DD”.ResultsWe present two clinical cases of patients who were admitted to psychiatric unit after developing psychotic symptoms namely persecutory delusions about neighbors.A persistent delusional disorder was established and antipsychotic treatment was initiated.The 74-years-old men presented deficits in executive and memory processes; ended up institutionalized after two months of being discharged.The 47-years-old woman, despite remaining as a lawyer, noticed a decrease in work capacity and so she ended up being responsible for less demanding cases.Cases of delusional disorder showed a poor performance in most cognitive tests and some of the cognitive deficits seem to affect functionality namely memory, expressive language and attention.ConclusionsAlthough classical literature has not systematized an association between DD and personality deterioration,there are some evidences of loss of functionality and cognitive commitment in this disorder.This suggests the importance of cognitive interventions to improve functional prognosis in this clinical population.DisclosureNo significant relationships.
The prevalence of self-harm behavior in schizophrenia spectrum disorders: a systematic review and meta-analysis
Authors: Lorentzen E. , Mors O. , Kjaer J.N. 
Published: September 2022

IntroductionNon-suicidal self-injury (NSSI) is intentional self-inflicted destruction of body tissue without suicidal intention, whereas deliberate self-harm (DSH) is self-inflicted destruction of body tissue regardless of intent. In clinical samples of patients with schizophrenia spectrum disorders (SSD) the estimates of prevalence and severity of self-harm behavior vary considerably.ObjectivesThe aim of this study is to investigate the prevalence of NSSI and DSH, respectively, in individuals with SSD.MethodsIn adherence with PRISMA guidelines, a search of electronic databases (Pubmed, PsycInfo, and EMBASE) was conducted by two independent reviewers. Studies were included if the participants were diagnosed with SSD and DSH/NSSI were quantified by questionnaire or interview. Studies solely including patients with schizoaffective disorder, a severe intellectual disability, or autistic spectrum disorder were excluded. Meta-analysis of prevalence will be undertaken for NSSI and DSH, respectively. Further, the review will examine psychopathological correlates to DSH/NSSI, self-harming methods utilized in DSH/NSSI, and severity of DSH/NSSI.ResultsFollowing duplicate removal, 1891 abstracts were initially identified through the database searches. 148 abstracts were included in screening of full-text articles of which 33 met the eligibility criteria. Nine authors were contacted for the purpose of obtaining additional data. Preliminary results found that the observed lifetime prevalence of NSSI ranged from 14.1% to 57.1%, whereas the observed lifetime prevalence of DSH ranged from 12.9% to 68.0%.ConclusionsUnderstanding how SSD and self-harming behavior are associated could identify subgroups of patients with SSD that are responsive to different pharmacological and psychosocial treatment approaches.DisclosureNo significant relationships.
The impact of traumatic childhood events on functioning in patients with schizophrenia
Authors: Neily C. , Charfi N. , Smaoui G. , Feki R. , Omri S. , Zouari L. , Ben Thabet J. , Maâlejboauli M. , Maalej M. 
Published: September 2022

Introduction
A history of adverse childhood experiences (ACEs) can increase the risk of schizophrenia spectrum disorders and might be related to unfavorable clinical and functional outcomes of psychosisObjectivesTo assess the relationship between the history of ACEs and functioning in stabilized patients with schizophrenia or schizoaffective disorder.MethodsWe conducted a cross-sectional, descriptive and analytical study. It was carried out on out patients with stabilized schizophrenia or schizoaffective disorder. The diagnosis of schizophrenia and schizoaffective disorder was established based on DSM-5 criteria. We used the ACEs scale to screen for traumatic events that occurred in the childhood and we used the Functional Assessment Staging Scale (FAST) to assess the patients’ ability to function and perform tasks of daily livingResultsSeventy five patients were included.The mean age was 39.81 ±9.96 years.The sex ratio was 4 .34. The mean score of ACE was 3.55 ± 2.41 and 88% of patients had experienced at least one traumatic event.The mean sore of the FAST scale was 33 ± 14.95.The total score of FAST was significantly higher in case of physical negligence in childhood (p=0.018). No correlation was found with the others ACEs.The FAST sub score of cognitive functioning correlated with the history of parents separation (p= 0.47) and physical negligence (p= 0.03). we also found that The FAST sub score of interpersonal relationships correlated with the history of emotional abuse (p=0.021)ConclusionsOur data has shown that ACEs contribute to functioning impairment in schizophrenia and schizoaffective disorder.This impairment affects mainly the cognitive functioning and the interpersonal relationshipsDisclosureNo significant relationships.
Risky Decision-Making in Schizophrenia: Examination of association between smoking, substance use and performance on the Iowa Gambling test: Pilot Study
Authors: Dannon P. , Kertzman S. 
Published: September 2022

IntroductionThere are two common hypotheses to explain such high comorbidity between nicotine dependence and schizophrenia (SZ): self-medication for decreasing psychiatric symptoms or common environmental risk factors can predispose to both nicotine dependence and other risky behaviors in SZObjectivesLittle is known about the influence of cigarette smoking comorbidities such substance use disorder (SUD), criminal history, or risky decision among patients with SZ.MethodsThe Iowa Gambling test (IGT) was administered to thirty-nine patients with SZ of whom 69% reporting cigarette smoking. Both groups were evaluated using a socio-demographic questionnaire and clinical assessment using PANSS and self-report questionnaire the Barratt Impulsiveness Scale (BIS-11). To evaluate decision making was evaluated with the Iowa Gambling Task (IGT).ResultsThe full SZ sample performed worse on the IGT then normal population. Smokers with SZ performed significantly worse than nonsmokers on the IGT primarily because they preferred “disadvantageous” decks to a greater degree. The PANSS and impulsivity tendencies (BIS-11) did not predict overall performance on the IGT. Smokers with SZ had impaired affective decision-making. Behavior suggested preferential attention to the frequency amount of gain and inattention to amount of loss suggesting impairments in risk/reward decision-makingConclusionsThis study is the first to compare IGT in smokers and nonsmokers with SZ with adjustment of SUD, criminal history, and existing tattoo to further examine IGT performance. These results support the hypothesis that comorbidities between nicotine dependence and SZ can be linked to other common factor that is associated with other externalizing behaviors in SZ.DisclosureNo significant relationships.
Folie à deux, about a case
Authors: Palomo Monge M. , Tascón Guerra M.F. , Pérez Fominaya M. , López Rodrigo M.V. , Osca Oliver A. , García Montero C. , Ros Font V. 
Published: September 2022

Introduction

First described in France by Lasègue and Falret as the presence of the same psychiatric symptom in 2 individuals. It involves the transference of delusional ideas from a “primary” affected individual to one or more “secondaries,” in close association.Objectives
We present the case of a patient, diagnosed with schizophrenia, who, after several years of evolution, and after a relapse, comes accompanied by his mother, who recently began to present the same delusional symptoms that the patient reported previously.MethodsAfter several pharmacological adjustments, control of the patient’s symptoms is achieved and it is he himself who is able to identify the symptoms that his mother presents, allowing her to also attend and be treated.ResultsInduced delusional disorder F.24ConclusionsAmong the variants that the folie a deux encompasses (folie imposée, folie communiquée, folie simultenée, folie induite) in this case we are probably talking about a folie communiquée, given the resistance over time of the patient’s mother until the symptoms develop. It is important to know these syndromes to be able to make a clear diagnosis, and depending on the way of onset and evolution, to be able to distinguish between the different subtypes, in order to avoid future complications and guide the corresponding treatment.DisclosureNo significant relationships.
Gender differences in patients attending Early Psychosis Intervention Programme
Authors: Mulero Garcia A.B. , Sánchez Martínez E. , Gómez Sanchez-Lafuente C. 
Published: September 2022

IntroductionStuding the scope of differences found in terms of gender in First Psychotic Episodes patients, should enhance our understanding of such disorders and improve the therapeutic approaches.ObjectivesOur main objective was to compare the sociodemographic variables between men and women included in the Early Intervention Program in Psychosis of the Regional University Hospital of Malaga between the years 2016-2020.MethodsRetrospective study in which the characteristics of 135 patients who started the Early Intervention Program in Psychosis of the Regional University Hospital of Malaga between the years 2016-2020 were analyzed. Statistical analysis was performed using SPSS 25.0. For the comparison of variables, Student’s t was used for quantitative variables and Chi square for dichotomous variables.ResultsPatients included in the Program; 32% were women and 68% were men. The average of age at the beginning was 35.56 for women and 28,47 for men. Most of the women were married and most of the men were single. The majority of men lived with their original family and for women with their own family. In relation with the consumption of toxins, alcohol and to smoke, were more frequent in men. More results in poster.ConclusionsDespite the limitations due to our study design, the results obtained are in agreement with some of the discussions that are currently in force. Given that, female gender is associated with lower risk of psychosis, better premorbid adjustment, lower drug consumption and a later onset of the disease in the first-episode psychosis.DisclosureNo significant relationships.
On the problem of the catatonic disorders taxonomy
Authors: Lobanova V. , Smulevich A. , Voronova E. 
Published: September 2022

IntroductionIn accordance with the systematics of modern international clinical guidelines (DSM-V, ICD-11), catatonia is qualified as a transnosological formation, which boundaries expandes by including non-psychotic movement disorders (hysterical, affective, negative, etc.). This study presents the psychopathological systematics of movement disorders, based on a new dimensional model of catatonia.Objectives60 patients with an established diagnosis of schizophrenia or SSD (F20, F21, F25.01, F25.11, F25.21, F25.22), catatonic disorders in the structure of which persist throughout the course of the disease or determine the clinical picture of phases.MethodsClinical, psychometric (BFCRS, SANS, SAPS, HADS), statistic.ResultsThree catatonic syndromes (S.) have been identified. 1. S. of stereotypical catatonia - presented by the mechanism of affiliation with negative symptoms (R between BFCRS Total Score (TS) and Avolition-Apathy SANS – 0,875): tendency to stereotypical activity; general, increasing slowness (SANS avolition-apathy -2,9±0,5; BFCRS TS – 11,1±0,2). 2. S. of parakinetic catatonia - includes paroxysms formes by the mechanism of mental automatism (with the loss of motor acts voluntary effect ) (R BFCRS TS/Persecutory Delusions SAPS– 0,764): irregular polymorphic movement disorders of hyperkinetic and akinetic types, impulsive actions, akinesias (Persecutory Delusions - 2,3±0,4; BFCRS – 19,5±2,3). 3. Affective - catatonic S. - including both the lightest (at the level of recurrent depression) variants of affective-catatonic phases (R BFCRS TS/HADS – 0,732; BFCRS – 5,1±0,4; HADS -15,1±2,4), and more severe affective-catatonic states based on schizoaffective psychoses (R BFCRS TS/SAPS TS– 0,783; BFCRS – 15,3±2,1; SAPS – 3,1±0,2).ConclusionsCatatonia is not a single dimension, represented by heterogeneous movement disorders, differing both in the mechanism of formation and in the psychopathological structure.DisclosureNo significant relationships.