bluuebunny/crossref_metadata_2025_split huggingface dataset:
A sound approach to advancing healthcare systems: the future of biomedical acoustics
Authors: Rufo Joseph , Zhang Peiran , Zhong Ruoyu , Lee Luke P. , Huang Tony Jun 
Published: June 2022

AbstractNewly developed acoustic technologies are playing a transformational role in life science and biomedical applications ranging from the activation and inactivation of mechanosensitive ion channels for fundamental physiological processes to the development of contact-free, precise biofabrication protocols for tissue engineering and large-scale manufacturing of organoids. Here, we provide our perspective on the development of future acoustic technologies and their promise in addressing critical challenges in biomedicine.
Generation and direct observation of a triplet arylnitrenium ion
Authors: Du Lili , Wang Juanjuan , Qiu Yunfan , Liang Runhui , Lu Penglin , Chen Xuebo , Phillips David Lee , Winter Arthur H. 
Published: June 2022

AbstractNitrenium ions are important reactive intermediates in both chemistry and biology. Although singlet nitrenium ions are well-characterized by direct methods, the triplet states of nitrenium ions have never been directly detected. Here, we find that the excited state of the photoprecursor partitions between heterolysis to generate the singlet nitrenium ion and intersystem crossing (ISC) followed by a spontaneous heterolysis process to generate the triplet p-iodophenylnitrenium ion (np). The triplet nitrenium ion undergoes ISC to generate the ground singlet state, which ultimately undergoes proton and electron transfer to generate a long-lived radical cation that further generates the reduced p-iodoaniline. Ab Initio calculations were performed to map out the potential energy surfaces to better understand the excited state reactivity channels show that an energetically-accessible singlet-triplet crossing lies along the N-N stretch coordinate and that the excited triplet state is unbound and spontaneously eliminates ammonia to generate the triplet nitrenium ion. These results give a clearer picture of the photophysical properties and reactivity of two different spin states of a phenylnitrenium ion and provide the first direct glimpse of a triplet nitrenium ion.
Terahertz thermal curve analysis for label-free identification of pathogens
Authors: Jun S. W. , Ahn Y. H. 
Published: June 2022

AbstractIn this study, we perform a thermal curve analysis with terahertz (THz) metamaterials to develop a label-free identification tool for pathogens such as bacteria and yeasts. The resonant frequency of the metasensor coated with a bacterial layer changes as a function of temperature; this provides a unique fingerprint specific to the individual microbial species without the use of fluorescent dyes and antibodies. Differential thermal curves obtained from the temperature-dependent resonance exhibit the peaks consistent with bacterial phases, such as growth, thermal inactivation, DNA denaturation, and cell wall destruction. In addition, we can distinguish gram-negative bacteria from gram-positive bacteria which show strong peaks in the temperature range of cell wall destruction. Finally, we perform THz melting curve analysis on the mixture of bacterial species in which the pathogenic bacteria are successfully distinguished from each other, which is essential for practical clinical and environmental applications such as in blood culture.
T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles
Authors: Céspedes Pablo F. , Jainarayanan Ashwin , Fernández-Messina Lola , Valvo Salvatore , Saliba David G. , Kurz Elke , Kvalvaag Audun , Chen Lina , Ganskow Charity , Colin-York Huw , Fritzsche Marco , Peng Yanchun , Dong Tao , Johnson Errin , Siller-Farfán Jesús A. , Dushek Omer , Sezgin Erdinc , Peacock Ben , Law Alice , Aubert Dimitri , Engledow Simon , Attar Moustafa , Hester Svenja , Fischer Roman , Sánchez-Madrid Francisco , Dustin Michael L. 
Published: June 2022

AbstractThe immunological synapse is a molecular hub that facilitates the delivery of three activation signals, namely antigen, costimulation/corepression and cytokines, from antigen-presenting cells (APC) to T cells. T cells release a fourth class of signaling entities, trans-synaptic vesicles (tSV), to mediate bidirectional communication. Here we present bead-supported lipid bilayers (BSLB) as versatile synthetic APCs to capture, characterize and advance the understanding of tSV biogenesis. Specifically, the integration of juxtacrine signals, such as CD40 and antigen, results in the adaptive tailoring and release of tSV, which differ in size, yields and immune receptor cargo compared with steadily released extracellular vesicles (EVs). Focusing on CD40L+tSV as model effectors, we show that PD-L1 trans-presentation together with TSG101, ADAM10 and CD81 are key in determining CD40L vesicular release. Lastly, we find greater RNA-binding protein and microRNA content in tSV compared with EVs, supporting the specialized role of tSV as intercellular messengers.
Observation of anomalous amplitude modes in the kagome metal CsV3Sb5
Authors: Liu Gan , Ma Xinran , He Kuanyu , Li Qing , Tan Hengxin , Liu Yizhou , Xu Jie , Tang Wenna , Watanabe Kenji , Taniguchi Takashi , Gao Libo , Dai Yaomin , Wen Hai-Hu , Yan Binghai , Xi Xiaoxiang 
Published: June 2022

AbstractThe kagome lattice provides a fertile platform to explore novel symmetry-breaking states. Charge-density wave (CDW) instabilities have been recently discovered in a new kagome metal family, commonly considered to arise from Fermi-surface instabilities. Here we report the observation of Raman-active CDW amplitude modes in CsV3Sb5, which are collective excitations typically thought to emerge out of frozen soft phonons, although phonon softening is elusive experimentally. The amplitude modes strongly hybridize with other superlattice modes, imparting them with clear temperature-dependent frequency shift and broadening, rarely seen in other known CDW materials. Both the mode mixing and the large amplitude mode frequencies suggest that the CDW exhibits the character of strong electron-phonon coupling, a regime in which phonon softening can cease to exist. Our work highlights the importance of the lattice degree of freedom in the CDW formation and points to the complex nature of the mechanism.
A single-cell transcriptomic atlas tracking the neural basis of division of labour in an ant superorganism
Authors: Li Qiye , Wang Mingyue , Zhang Pei , Liu Yang , Guo Qunfei , Zhu Yuanzhen , Wen Tinggang , Dai Xueqin , Zhang Xiafang , Nagel Manuel , Dethlefsen Bjarke Hamberg , Xie Nianxia , Zhao Jie , Jiang Wei , Han Lei , Wu Liang , Zhong Wenjiang , Wang Zhifeng , Wei Xiaoyu , Dai Wei , Liu Longqi , Xu Xun , Lu Haorong , Yang Huanming , Wang Jian , Boomsma Jacobus J. , Liu Chuanyu , Zhang Guojie , Liu Weiwei 
Published: June 2022

AbstractAnt colonies with permanent division of labour between castes and highly distinct roles of the sexes have been conceptualized to be superorganisms, but the cellular and molecular mechanisms that mediate caste/sex-specific behavioural specialization have remained obscure. Here we characterized the brain cell repertoire of queens, gynes (virgin queens), workers and males ofMonomorium pharaonisby obtaining 206,367 single-nucleus transcriptomes. In contrast toDrosophila, the mushroom body Kenyon cells are abundant in ants and display a high diversity with most subtypes being enriched in worker brains, the evolutionarily derived caste. Male brains are as specialized as worker brains but with opposite trends in cell composition with higher abundances of all optic lobe neuronal subtypes, while the composition of gyne and queen brains remained generalized, reminiscent of solitary ancestors. Role differentiation from virgin gynes to inseminated queens induces abundance changes in roughly 35% of cell types, indicating active neurogenesis and/or programmed cell death during this transition. We also identified insemination-induced cell changes probably associated with the longevity and fecundity of the reproductive caste, including increases of ensheathing glia and a population of dopamine-regulatedDh31-expressing neurons. We conclude that permanent caste differentiation and extreme sex-differentiation induced major changes in the neural circuitry of ants.
Lexibank, a public repository of standardized wordlists with computed phonological and lexical features
Authors: List Johann-Mattis , Forkel Robert , Greenhill Simon J. , Rzymski Christoph , Englisch Johannes , Gray Russell D. 
Published: June 2022

AbstractThe past decades have seen substantial growth in digital data on the world’s languages. At the same time, the demand for cross-linguistic datasets has been increasing, as witnessed by numerous studies devoted to diverse questions on human prehistory, cultural evolution, and human cognition. Unfortunately, most published datasets lack standardization which makes their comparison difficult. Here, we present a new approach to increase the comparability of cross-linguistic lexical data. We have designed workflows for the computer-assisted lifting of datasets to Cross-Linguistic Data Formats, a collection of standards that make these datasets more Findable, Accessible, Interoperable, and Reusable (FAIR). We test the Lexibank workflow on 100 lexical datasets from which we derive an aggregated database of wordlists in unified phonetic transcriptions covering more than 2000 language varieties. We illustrate the benefits of our approach by showing how phonological and lexical features can be automatically inferred, complementing and expanding existing cross-linguistic datasets.
Fabrication and improved response of ZnO-CdO composite films under different laser irradiation dose
Authors: Zargar Rayees Ahmad 
Published: June 2022

AbstractPromising Zinc Oxide (ZnO) and Cadmium Oxide (CdO) alloy (ZnO-CdO) films were fabricated on glass substrates by screen printing route for optoelectronic applications. The Nd:YAG green diode laser of wavelength 532 nm and laser fluence of 1.8 J/cm2 was used to irradiate the fabricated films at room temperature. The characterization of these films were systematically studied by means of X-ray diffraction (XRD), UV–vis, photoluminescence (PL), Raman spectroscopy and two probe method for conductivity measurement. The XRD pattern shows that all the films were well crystallized with maximum diffraction of (101) plane and mixed phases of ZnO and CdO were detected. The structure, space group and other crystal related parameters were confirmed from Rietveld refinement of XRD data. The basic optical parameters (band gap, refractive index and extinction coefficient) have been estimated using absorbance spectra. The PL spectrum of ZnO-CdO composite films exhibits red shift and blue- green emissions shift upon laser irradiation were confirmed from CIE 1931 diagram. The Raman spectroscopy indicates that the quality of the ZnO-CdO films was increased while their structure defects were increased. DC conductivity measurement confirms semiconductor behaviour. All the parameters such as particle size, optical constants, colour emission and activation energy have been significantly improved upon laser irradiations dose of 1.8 J/cm2 for different durations of time. This study could be appropriate for optoelectronic applications.
Partial randomized benchmarking
Authors: Dubovitskii Kirill , Makhlin Yuriy 
Published: June 2022

AbstractIn randomized benchmarking of quantum logical gates, partial twirling can be used for simpler implementation, better scaling, and higher accuracy and reliability. For instance, for two-qubit gates, single-qubit twirling is easier to realize than full averaging. We analyze such simplified, partial twirling and demonstrate that, unlike for the standard randomized benchmarking, the measured decay of fidelity is a linear combination of exponentials with different decay rates (3 for two qubits and single-bit twirling). The evolution with the sequence length is governed by an iteration matrix, whose spectrum gives the decay rates. For generic two-qubit gates one slowest exponential dominates and characterizes gate errors in three channels. Its decay rate is close, but different from that in the standard randomized benchmarking, and we find the leading correction. Using relations to the local invariants of two-qubit gates we identify all exceptional gates with several slow exponentials and analyze possibilities to extract their decay rates from the measured curves.
Stretchable printed device for the simultaneous sensing of temperature and strain validated in a mouse wound healing model
Authors: Jose Manoj , Bronckaers Annelies , Kumar Rachith Shanivarasanthe Nithyananda , Reenaers Dieter , Vandenryt Thijs , Thoelen Ronald , Deferme Wim 
Published: June 2022

AbstractTemperature and strain are two vital parameters that play a significant role in wound diagnosis and healing. As periodic temperature measurements with a custom thermometer or strain measurements with conventional metallic gauges became less feasible for the modern competent health monitoring, individual temperature and strain measurement modalities incorporated into wearables and patches were developed. The proposed research in the article shows the development of a single sensor solution which can simultaneously measure both the above mentioned parameters. This work integrates a thermoelectric principle based temperature measurement approach into wearables, ensuring flexibility and bendability properties without affecting its thermo-generated voltage. The modified thermoelectric material helped to achieve stretchability of the sensor, thanks to its superior mechano-transduction properties. Moreover, the stretch-induced resistance changes become an additional marker for strain measurements so that both the parameters can be measured with the same sensor. Due to the independent measurement parameters (open circuit voltage and sensor resistance), the sensing model is greatly attractive for measurements without cross-sensitivity. The highly resilient temperature and strain sensor show excellent linearity, repeatability and good sensitivity. Besides, due to the compatibility of the fabrication scheme to low-temperature processing of the flexible materials and to mass volume production, printed fabrication methodologies were adopted to realize the sensor. This promises low-cost production and a disposable nature (single use) of the sensor patch. For the first time, this innovative temperature-strain dual parameter sensor concept has been tested on mice wounds in vivo. The preliminary experiments on mice wounds offer prospects for developing smart, i.e. sensorized, wound dressings for clinical applications.
Effect of hydrogen on magnetic properties in MgO studied by first-principles calculations and experiments
Authors: Fongkaew Ittipon , Yotburut Benjaporn , Sailuam Wutthigrai , Jindata Warakorn , Thiwatwaranikul Theerawee , Khamkongkaeo Atchara , Chuewangkam Nattapong , Tanapongpisit Nantawat , Saenrang Wittawat , Utke Rapee , Thongbai Prasit , Pinitsoontorn Supree , Limpijumnong Sukit , Meevasana Worawat 
Published: June 2022

AbstractWe investigated the effects of both intrinsic defects and hydrogen atom impurities on the magnetic properties of MgO samples. MgO in its pure defect-free state is known to be a nonmagnetic semiconductor. We employed density-functional theory and the Heyd–Scuseria–Ernzerhof (HSE) density functional. The calculated formation energy and total magnetic moment indicated that uncharged $${\mathrm{V}}_{\mathrm{Mg}}^{0}$$

V

Mg

0

and singly charged $${\mathrm{V}}_{\mathrm{Mg}}^{-1}$$

V

Mg

-
1

magnesium vacancies are more stable than oxygen vacancies (VO) under O-rich growth conditions and introduce a magnetic moment to MgO. The calculated density of states (DOS) results demonstrated that magnetic moments of VMg result from spin polarization of an unpaired electron of the partially occupied valence band, which is dominated by O 2p orbitals. Based on our calculations, VMg is the origin of magnetism and ferromagnetism in MgO. In contrast, the magnetic moment of the magnetic VMg-MgO crystal is suppressed by hydrogen (H) atoms, and unpaired electrons are donated to the unpaired electronic states of VMg when the defect complex Hi-VMg is formed. This suggests that H causes a reduction in magnetization of the ferromagnetic MgO. We then performed experimental studies to verify the DFT predictions by subjecting the MgO sample to a thermal treatment that creates Mg vacancies in the structure and intentionally doping the MgO sample with hydrogen atoms. We found good agreement between the DFT results and the experimental data. Our findings suggest that the ferromagnetism and diamagnetism of MgO can be controlled by heat treatment and hydrogen doping, which may find applications in magnetic sensing and switching under different environmental conditions.
Serum folate levels and hypertension
Authors: Lee Yoonkyung , Park Sangshin 
Published: June 2022

AbstractWe aimed to examine the association between serum folate levels and hypertension in Korean adults. Our study population was 6343 Korean adults whose blood pressure and folate levels were measured in the Korea National Health and Nutrition Examination Survey 2016–2018. We aggregated the study populations into quintiles according to serum folate levels (1.5–4.3, 4.4–5.7, 5.8–7.5, 7.6–10.3, and 10.4–35.9 ng/mL). Multivariable logistic and linear regression models were used to analyze the relationships between serum folate levels, blood pressure, and hypertension. The weighted average of serum folate levels was 7.4 ng/mL, and the weighted prevalence of hypertension was 30.4% in the study populations. After adjusting for all potential confounders, compared to those in the lowest quintile of serum folate levels, systolic and diastolic blood pressure of the people in the other quintiles were not significantly different. The linear relationship between serum folate levels and blood pressure was not statistically significant. The odds for hypertension were not significantly different across the quintiles of serum folate levels. This study showed high serum folate levels was not significantly associated with lowering hypertension in Korean adults.
An assessment of branching asymmetry of the tracheobronchial tree
Authors: Miguel Antonio F. 
Published: June 2022

AbstractThe tracheobronchial tree is commonly seen to have a systematic branching symmetry, despite being known to have an asymmetrical design. Branching asymmetry allows for uniform airflow and provides robustness against the morphogenesis-related size variability. Here, a constructal approach is used to tracheobronchial tree analysis, and a general model based on entropy generation during breathing process is provided, which holds with asymmetric characteristics of the tree, and the change for inhaling and exhaling air. In contrast to traditional models available in the literature, the entropy generation of inspiration and expiration processes is compared for symmetry and asymmetric designs. This approach unravels the fundamental consequences of asymmetric constraint in the process of breathing and provides justification for the tracheobronchial tree having the same number of bifurcation levels as optimized symmetrical trees.
903 Protein Saver cards: the best alternative for dried blood spot storage at room temperature for HCV RNA
Authors: Arca-Lafuente Sonia , Casanueva-Benítez Cristina , Crespo-Bermejo Celia , Lara-Aguilar Violeta , Martín-Carbonero Luz , de los Santos Ignacio , Madrid Ricardo , Briz Verónica 
Published: June 2022

AbstractHepatitis C virus (HCV) infection remains a global health problem, detected only in the early stages by molecular tests. Molecular tests detect HCV RNA, which is very prone to degradation by ribonucleases, reason why blood samples must be transported and stored at − 20 °C, or even − 70 °C for long-term storage. Flinders Technology Associates (FTA) cards are a useful sampling collecting device for dry blood spot (DBS) storage, especially for low and middle-income countries (LMIC). In this study, we analyzed viral HCV RNA integrity for long-term storage at room temperature compared to − 20 °C using two different types of cards for DBS: FTA Classic and 903 Protein Saver cards. For this purpose, DBS were prepared on these cards using blood or plasma samples from HCV infected patients, and samples were analysed by conventional RT-PCR. Our results showed that 903 Protein Saver cards are the best and cheapest alternative for DBS storage at room temperature. In these conditions, we found that HCV RNA integrity lasted for up to 9 months.
Resonance capture and long-term evolution of planets in binary star systems
Authors: Roisin A. , Doukhanin N. , Teyssandier J. , Libert A.-S. 
Published: June 2022

Aims. The growing population of planets discovered in orbit around one stellar component of a binary star raises the question of the influence of the binary companion on the formation process of planetary systems. The aim of this work is to study the impact of a binary companion on the evolution of two-planet systems during both the Type-II migration phase and their long-term evolution after the dissipation of the protoplanetary disk.
Methods. We used the symplectic integrator SyMBA, modified to include a wide binary companion. We also included the Type-II migration of giant planets during the protoplanetary disk phase with suitable eccentricity and inclination damping as well as the gravitational potential acting on the planets due to the disk and the nodal precession of the disk induced by the binary companion. We considered various inclinations, eccentricities, and separations of the binary companion.
Results. Disk migration allows for the formation of planet pairs in mean-motion resonances despite the presence of the binary companion. When the binary separation is wide (1000 au), the timescale of the perturbations that it raises on the planets is longer than the disk’s lifetime and resonant pairs are routinely formed in the 2:1, 5:2, and 3:1 commensurabilities. Provided the planet-planet interaction timescale is smaller than the timescale of binary perturbations, these systems can remain in resonance long after the disk has dissipated. When the binary separation is smaller (250 au), only planets in the 2:1 resonance tend to remain in a resonant state and more chaotic evolutions are observed, as well as more ejections. After those ejections, the remaining planet can become eccentric due to the perturbations from the binary companion in addition, for strongly inclined binary companions, captures in the von Ziepel-Lidov-Kozai resonance can occur. Whereas in systems with two planets, this mechanism is quenched by planet-planet interactions. Our simulations reveal that the interplay between planet-disk, planet-planet, and planet-binary interactions can lead to the formation of resonant pairs of planets which remain stable over timescales much longer than the disk’s lifetime.