bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yield reduction due to diseases and lodging and impact of input intensity on yield in variety trials in five cereal crops
Authors: Laidig F. , Feike T. , Klocke B. , Macholdt J. , Miedaner T. , Rentel D. , Piepho H. P. 
Published: September 2022

AbstractBreeding of multi-resistant varieties to reduce yield loss due to disease damage and lodging, and reduction of input intensity are of high importance for a more sustainable cereal production. The aim of this study was to evaluate (i) yield reduction caused by diseases and lodging and (ii) impact of input intensity and soil fertility in cereal variety trials grown under two intensities. Intensity 2 was treated with and intensity 1 without fungicides and growth regulators. We applied multiple regression approaches based on mixed linear models. First, we estimated relative yield reduction in intensity 1 compared to intensity 2 as a function of severity scores of diseases and lodging. High yield reductions occurred in winter wheat and winter triticale, moderate in winter rye and winter barley and low in spring barley. The damage potential was highest for yellow rust, followed by brown rust, lodging and Septoria tritici blotch. Medium damage potential was identified for dwarf leaf rust and low for powdery mildew, Septoria nodorum blotch, Rhynchosporium as well as for stem and ear buckling. Second, differences in input intensity did not affect yield in intensity 2 across the range of nitrogen and fungicide application rates while higher yield occurred at higher growth regulator rates and soil fertility. Growth regulator was strongly related with higher yield in winter rye and winter barley, however in spring barley, a negative relation was found. Soil fertility showed the strongest yield impact in all crops.
Social Position and Social Status: An Institutional and Relational Sociological Conception
Authors: Farkas Zoltán 
Published: September 2022

AbstractIn this article, I discuss the concepts of social position and social status, the types of social position, as well as the determinedness of social statuses by the given positions in a new approach. In the first, introductory part of the article, I emphasize that the institutional sociological conception of social position in my approach is relatively closest to the structuralist position conception. In the second part, I introduce two different concepts, labelled social position and social status, and briefly review the social determinedness of social status. In the third part, social positions are typified from the point of view of the two components of social position: on the one hand, from that of social power relations and on the other from that of interest relations. I point out that the different social positions promote the realization of interests to different degrees, that is, they make it possible to attain different social statuses. In a related article, I illustrate the concepts and connections in question with a case study carried out on an industrial shop floor.
zhi-{yao, you} ‘only-{need, have}’: on two conditional connectives in Mandarin
Authors: Wimmer Alexander 
Published: September 2022

AbstractThis paper offers a compositional take on two internally complex conditional connectives in Mandarin, zhi-yao ‘only-need’ and zhi-you ‘only-have’. While the former conveys the antecedent proposition’s minimal sufficiency, the latter conveys its necessity for the consequent proposition to come true. Both connectives will be treated as pairing an exclusive particle, zhi, with a modal, an assumption that is less controversial for the necessity modal yao than for you, which will be treated as a possibility modal. Accepting this treatment, however, we have two connectives that openly differ in modal force. While the surface order will be preserved for zhi-you, an inversion will be shown to lead to better results for zhi-yao. In both cases, a possible extension to monoclausal uses is considered.
Gamma Radiation Induced Synthesis of Novel Chitosan/Gold/Bioactive Glass Nanocomposite for Promising Antimicrobial, and Antibiofilm Activities
Authors: El-Sayyad Gharieb S. , Abdel Maksoud M. I. A. , Fahim Ramy Amer , Bekhit Mohamad , Kassem Said M. , Awed A. S. , Gobara Mohamed , El-Batal Ahmed I. , Ashour A. H. , Elkhatib Walid F. , Abd El-Aziz Salim Mohamed 
Published: September 2022

AbstractIn the present study we reported, for the first time, the gamma irradiation induced synthesis of chitosan/Au/bioactive glass (CS/Au/BG) nanocomposite. The bioactive glass (BG), with the composition 45% SiO2, 32.5% CaO, 15% Na2O, and 7.5% P2O5 wt% was synthesized through the sol–gel technique. XRD, SEM, EDX, and elemental mapping images were utilized to evaluate the structure of pure BG and CS/Au/BG nanocomposite. The antimicrobial efficacy was evaluated by zone of inhibition (ZOI), minimum inhibitory concentration (MIC), growth curve assay, and Ultraviolet irradiation effect. Investigation was carried on the antibiofilm effectiveness. Membrane leakage as well as SEM imaging were used to evaluate the antibacterial reaction mechanism. The crystallite size of CS/Au/BG nanocomposite was determined via Scherer equation as 22.83 nm. CS/Au/BG possessed the most ZOI activity against the tested microbes. The highest inhibition % of BG, and CS/Au/BG nanocomposite was investigated for S. aureus (15.65%, and 77.24%), followed by C. albicans (13.32%, and 64.75%). The quantity of protein leakage was directly-proportional after increasing the concentration of BG, and CS/Au/BG and counted to be 70.58, and 198.25 µg/mL, respectively (after applied 10 mg/mL). The promising results suggested the use of novel CS/Au/BG nanocomposite as an encourage candidate for wastewater treatment application against pathogenic microbes.
Finding the Person in the Disorder: Adapting Metacognitive Reflection and Insight Therapy for Bipolar Mood Disorder (MERIT-BD)
Authors: Schweitzer Robert , Sonnenburg Cherie , Komandur Priyanka 
Published: September 2022

AbstractMetacognitive Reflection and Insight Therapy (MERIT) was originally developed as an integrative recovery-oriented therapeutic approach to address the needs of people with a diagnosis of schizophrenia and other forms of severe mental illness. The approach, conceptualized as transtheoretical, aims to promote a more coherent and synthetic sense of self, through stimulating insight, sense of coherence, and metacognitive capacity. We argue that MERIT therapy, designed to facilitate peoples’ ability to form complex ideas about themselves and others and to use this knowledge to respond to psychological problems, has application in addressing deficits associated with bipolar disorder (BD), where there may be a significant injury to the person’s sense of self. That is, the therapy addresses the nascent sense of self in a context where disturbance of mood is dominant, and in relation to the experience of episodic manic episodes which may be understood as dissociative events, often associated with shame. The application of the therapeutic approach, which we term MERIT-BD draws upon MERIT’s primary principle of facilitating complexity and integration of the self, and additionally addresses shame, allowing for the facilitation of metacognitive capacity and insight in the context of finding the person. This approach will be illustrated with case vignettes illustrating the application of key components of MERIT-BD. Early findings drawn from a series of case studies are encouraging.
Healthcare Students’ and Educators’ Views on the Integration of Gender-Based Violence Education into the Curriculum: a Qualitative Inquiry in Three Countries
Authors: Sammut Dana , Ferrer Lilian , Gorham Emily , Hegarty Kelsey , Kuruppu Jacqueline , Salvo Francisca Lopez , Bradbury-Jones Caroline 
Published: September 2022

Abstract
Purpose
Health and social care professionals are ideally placed to identify and address gender-based violence (GBV), yet research continues to demonstrate that the subject is being poorly covered at undergraduate level. This qualitative study explored health and social care students’ and educators’ views on GBV education, with a view to identifying ‘best practice’. We aimed to capture students’ and educators’ experiences and perceptions of GBV education across participating countries; how participants thought GBV should be taught/learned within their curricula; and their views on how GBV education might be ‘optimized’.

Methods
We conducted nine focus group discussions and one semi-structured interview with 23 students and 21 academic staff across the UK, Australia and Chile.

Results
Thematic analysis yielded three themes: (1) GBV addressed in all but name, (2) Introduce sooner, explore later and (3) A qualitative approach to learning. Educators and students indicated that GBV is largely being overlooked or incompletely addressed within curricula. Many participants expressed a wish for the subject to be introduced early and revisited throughout their study, with content evolving as cohorts mature. Lastly, our findings indicate that GBV education could benefit from adopting a ‘qualitative’ approach, prioritizing survivor narratives and incorporating dialogue to facilitate student engagement.

Conclusion
Though time constraints and competing demands within undergraduate curricula are frequently cited as barriers to moving away from traditional didactic methods, our findings suggest that teacher-centered strategies are insufficient and, in some regards, inappropriate for GBV education. The need for a paradigm shift in GBV education is discussed.
Assessment of Flooding Impact on Water Supply Systems: A Comprehensive Approach Based on DSS
Authors: Barbetta Silvia , Bonaccorsi Bianca , Tsitsifli Stavroula , Boljat Ivana , Argiris Papakonstantinou , Reberski Jasmina Lukač , Massari Christian , Romano Emanuele 
Published: September 2022

AbstractThe assessment of flood impact on a Water Supply System (WSS) requires a comprehensive approach including several scales of analysis and models and should be managed in the Water Safety Plans (WSP), as recommended in the EU Water Directive 2020/2184. Flooding can affect the quality of groundwater and surface water resources and can cause supply service interruption due to damaged infrastructures. A complete approach to address flood impact on WSS is required but not yet available, while only specific aspects were investigated in details. This work introduces a comprehensive tool named WAter Safety Planning Procedures Decision Support System (WASPP–DSS) developed in the context of MUHA (Multihazard framework for Water Related risks management) project. The tool is mainly addressed to small water utilities (WU) for supporting WSP development and is based on two main premises: 1) a correct approach for WSS risk analysis requires a multi-hazard perspective encompassing all the system components and different hazards; 2) other institutions in addition to WUs have to be involved in WSS risk analyses to harmonize monitoring and response procedures. The tool is here applied on risks associated to flooding and demonstrated for three case studies. The WASPP–DSS, tested by eight WUs, was found a potentially valid support for small WUs that must start drafting the WSP in a comprehensive way and can provide a common shared scheme. Improvements are desirable, as including a specific section to consider the issue of loss of water resources from reservoirs due to overflow.
Relation of pandemics with solar cycles through ozone, cloud seeds, and vitamin D
Authors: Lee Kwan Chul , Kim Jung Sun , Kwak Young Sil 
Published: September 2022

Abstract
The global records of infectious diseases, including Western and Eastern documents from 1825 to 2020, during which sunspot observations are considered reliable, show that 27 of the 34 pandemic outbreaks were coincident with sunspot number maxima or minima. There is evidence that the intensity of galactic cosmic rays is anti-correlated with solar activity and that cloud seed formation is accelerated by galactic cosmic rays. There are a substantial number of research papers showing the relationship between COVID-19 and vitamin D deficiency. The data analysis of ozone thickness measured based on NASA satellite observations revealed that ozone thickness has 11-year and 28-month cycles. Because the 11-year cycles of ozone thickness and cloud seed attenuation are anti-correlated, when either one becomes extremely thick, such as at the maximum or minimum point of solar activity, UV radiation is over-attenuated, and human vitamin D deficiency is globally increased. This finding explains the coincidence of pandemic outbreaks with the extrema of the sunspot numbers. Vitamin D supplementation can be an effective countermeasure against the spread of infectious diseases, which is a paramount importance to global society. Future pandemic forecasting should include the 11-year and 28-month cycles of UV radiation. This founding completes the relationship between solar activity and human health through the earth’s environment.
Diabetestechnologie abseits von Insulinpumpen und Sensoren
Authors: Laimer Markus 
Published: September 2022

ZusammenfassungZu Diabetestechnologien abseits von Insulinpumpen und Glukosesensoren zählen Verfahren, welche einerseits das Diabetesselbstmanagement und andererseits die medizinische Betreuung, therapeutische Anpassungen und Schulungen durch Diabetesfachpersonen unterstützen. Diabetes-Apps sind in einer großen Anzahl und Vielfalt in den App-Stores für unterschiedliche Systeme verfügbar. Die Funktionalitäten variieren, und nur einige Apps bringen im klinischen Alltag einen Mehrwert im Sinne einer automatisierten Insulindokumentation (in Verbindung mit Smartpens), Insulindosiskalkulation oder Bereitstellung therapierelevanter Informationen bezüglich der Mahlzeitenzusammensetzung. Die seit kurzem am Markt verfügbaren Smartpens entsprechen grundsätzlich konventionellen, wiederbefüllbaren Insulinpens, sind jedoch um die Möglichkeit, die Dosis und den Zeitpunkt einer Insulingabe zu speichern, erweitert. Die dokumentierten Insulinabgaben ermöglichen in Zusammenschau mit den Glukosewerten eine detailliertere Analyse mit Darstellung und Objektivierung von Optimierungspotenzialen. Eine weitere Unterstützung für Menschen mit Diabetes stellen Apps mit hinterlegten Mahlzeitendatenbanken und der Möglichkeit der Mahlzeitendokumentation dar, die auch in der Adipositastherapie verwendet werden. Die technologische Weiterentwicklung der Kamerasysteme und Sensoren von Smartphones führen zudem zu immer genaueren Möglichkeiten einer automatisierten Erkennung der Mahlzeitenzusammensetzung. Bei all der Euphorie über die zunehmenden und mannigfaltigen Möglichkeiten neuer Diabetestechnologien muss der Fokus weiterhin auf deren Bedienungsfreundlichkeit und Anwendbarkeit durch eine möglichst große Anzahl von Personen mit Diabetes gerichtet bleiben. Ebenso muss der Umgang mit durch Apps erhobenen Gesundheitsdaten und cloudbasierten Anwendungen die regulatorischen Standards und damit den Schutz des Individuums erfüllen und v. a. akzeptieren.
Back-calculation of soil parameters from displacement-controlled cavity expansion under geostatic stress by FEM and machine learning
Authors: Patino-Ramirez Fernando , Wang Zijie Jay , Chau Duen Horng , Arson Chloe 
Published: September 2022

AbstractEstimating soil properties from the mechanical reaction to a displacement is a common strategy, used not only in in situ soil characterization (e.g., pressuremeter and dilatometer tests) but also by biological organisms (e.g., roots, earthworms, razor clams), which sense stresses to explore the subsurface. Still, the absence of analytical solutions to predict the stress and deformation fields around cavities subject to geostatic stress, has prevented the development of characterization methods that resemble the strategies adopted by nature. We use the finite element method (FEM) to model the displacement-controlled expansion of cavities under a wide range of stress conditions and soil properties. The radial stress distribution at the cavity wall during expansion is extracted. Then, methods are proposed to prepare, transform and use such stress distributions to back-calculate the far field stresses and the mechanical parameters of the material around the cavity (Mohr-Coulomb friction angle$$\phi $$ϕ, Young’s modulusE). Results show that: (i) The initial stress distribution around the cavity can be fitted to a sum of cosines to estimate the far field stresses; (ii) By encoding the stress distribution as intensity images, in addition to certain scalar parameters, convolutional neural networks can consistently and accurately back-calculate the friction angle and Young’s modulus of the soil.
The Longitudinal Association of Childhood and Adolescent Television Viewing with Substance Use Disorders and Disordered Gambling in Adulthood up to Age 45
Authors: McAnally H. M. , Wiki Te Oi A. , Nada-Raja S. , Hancox R. J. 
Published: September 2022

AbstractExcessive leisure-time television viewing in childhood has been associated with a range of poorer outcomes in adulthood and may represent an early form of addictive disorder. As addictive disorders are often correlated, we tested the hypothesis that television viewing in childhood and adolescence would be longitudinally associated with adulthood substance-related and behavioural addictive disorders in a population-based cohort born in 1972/1973. Weekday television viewing time was reported at multiple ages from 5 to 15 years, and criteria for alcohol, cannabis, and tobacco use disorders and disordered gambling were assessed at multiple adult ages up to 45 years. Higher television viewing times were associated with a greater likelihood of meeting diagnostic criteria for all substance-related disorders and disordered gambling in models that were adjusted for sex (p values < 0.05). After adjustment for childhood socioeconomic status and childhood self-control, mean television viewing time (hours/day) remained associated with tobacco use disorder (OR = 1.22, 95% CI = 1.04–1.42, p = 0.017) and disordered gambling (OR = 1.33, 95% CI = 1.07–1.66, p = 0.010). Excessive, leisure-time television viewing in childhood and adolescence may be a modifiable risk factor for tobacco use disorder and/or disordered gambling in later life.
isoAOT40: An improved ozone exposure index based on the Annual Ozone Spectrum Profile (AO3SP)
Authors: Agathokleous Evgenios , Saitanis Costas J. , Agathokleous Stefanos , Savvides Chrysanthos , Calatayud Vicent , Sicard Pierre 
Published: September 2022

AbstarctIn recognition of the rising threats of ground-level ozone (O3) pollution to forests, agricultural crops, and other types of vegetation, accurate and realistic risk assessment is urgently needed. The accumulated O3 exposure over a concentration threshold of 40 nmol mol−1 (AOT40) is the most commonly used metric to investigate O3 exposure and its effects on vegetation and to conduct vegetation risk assessment. It is also used by international regulatory authorities for deriving critical levels and setting standards to protect vegetation against surface O3. However, fixed periods of the growing season are used universally, yet growing seasons vary with latitudes and elevations, and the periods of plant lifespan also differ among annual species. Here, we propose the concept of the Annual O3 Spectrum Profile (AO3SP) and apply it to calculate the profile of AOT40 throughout the year (AAOT40SP, Annual AOT40 Spectrum Profile) using the International Organization for Standardization (ISO) weeks as a shorter window ISO-based accumulated exposure. Using moving time periods of three (for crops) or six (for forests) months, the isoAOT40 behavior throughout the year can be examined as a diagnostic tool for O3 risks in the short- or long-term during the lifecycle of local vegetation. From this analysis, AOT40 (isoAOT40) that is most representative for the local conditions and specific situations can be identified, depending on the exact growing season and lifecycle of the target vegetation. We applied this novel approach to data from five background monitoring stations located at different elevations in Cyprus. Our results show that the AAOT40SP approach can be used for improved and more realistic assessment of O3 risks to vegetation. The AO3SP approach can also be applied using metrics other than AOT40 (exposure- or flux-based), adding a new dimension to the way O3 risk to vegetation is assessed.
Mechanism of action of DSP-7888 (adegramotide/nelatimotide) Emulsion, a peptide-based therapeutic cancer vaccine with the potential to turn up the heat on non-immunoreactive tumors
Authors: Suginobe Natsuko , Nakamura Megumi , Takanashi Yosuke , Ban Hitoshi , Gotoh Masashi 
Published: September 2022

Abstract
Background
Wilms’ tumor 1 (WT1) is highly expressed in various solid tumors and hematologic malignancies. DSP-7888 (adegramotide/nelatimotide) Emulsion is an investigational therapeutic cancer vaccine comprising three synthetic epitopes derived from WT1. We evaluated the mechanism of action of DSP-7888 Emulsion, which is hypothesized to induce WT1-specific cytotoxic T lymphocytes (CTLs) and helper T lymphocytes (HTLs).

Methods
The ability of nelatimotide and adegramotide to induce WT1-specific CD8+ T cells and CD4+ T cells was assessed in human peripheral blood mononuclear cells (PBMCs). The ability of DSP-7888 Emulsion to induce WT1-specific CTLs in vivo was assessed using human leukocyte antigen-I (HLA-I) transgenic mice. To assess how adegramotide, the helper peptide in DSP-7888 Emulsion, enhances WT1-specific CTLs, HLA-I transgenic mice were administered DSP-7888 or nelatimotide-only Emulsion. Interferon-gamma secretion under antigen stimulation by splenocytes co-cultured with or without tumor cells was then quantified. The effects of combination treatment with DSP-7888 Emulsion and an anti–programmed cell death protein 1 (PD-1) antibody on tumor volume and the frequency of tumor-infiltrating WT1-specific T cells were assessed in HLA-I transgenic mice implanted with WT1 antigen-positive tumors.

Results
The peptides in DSP-7888 Emulsion were shown to induce WT1-specific CTLs and HTLs in both human PBMCs and HLA-I transgenic mice. Unlike splenocytes from nelatimotide-only Emulsion-treated mice, splenocytes from DSP-7888 Emulsion-treated mice exhibited high levels of interferon-gamma secretion, including when co-cultured with tumor cells; interferon-gamma secretion was further enhanced by concomitant treatment with anti-PD-1. HLA-I transgenic mice administered DSP-7888 Emulsion plus anti-PD-1 experienced significantly greater reductions in tumor size than mice treated with either agent alone. This reduction in tumor volume was accompanied by increased numbers of tumor-infiltrating WT1-specific CTLs.

Conclusions
DSP-7888 Emulsion can promote both cytotoxic and helper T-cell-mediated immune responses against WT1-positive tumors. Adegramotide enhances CTL numbers, and the CTLs induced by treatment with both nelatimotide and adegramotide are capable of functioning within the immunosuppressive tumor microenvironment. The ability of anti-PD-1 to enhance the antitumor activity of DSP-7888 Emulsion in mice implanted with WT1-positive tumors suggests the potential for synergy.