bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology
Authors: Temerozo Jairo R. , Fintelman-Rodrigues Natalia , dos Santos Monique Cristina , Hottz Eugenio D. , Sacramento Carolina Q. , de Paula Dias da Silva Aline , Mandacaru Samuel Coelho , dos Santos Moraes Emilly Caroline , Trugilho Monique R. O. , Gesto João S. M. , Ferreira Marcelo Alves , Saraiva Felipe Betoni , Palhinha Lohanna , Martins-Gonçalves Remy , Azevedo-Quintanilha Isaclaudia Gomes , Abrantes Juliana L. , Righy Cássia , Kurtz Pedro , Jiang Hui , Tan Hongdong , Morel Carlos , Bou-Habib Dumith Chequer , Bozza Fernando A. , Bozza Patrícia T. , Souza Thiago Moreno L. 
Published: April 2022

Abstract
Background
Critically ill 2019 coronavirus disease (COVID-19) patients under invasive mechanical ventilation (IMV) are 10 to 40 times more likely to die than the general population. Although progression from mild to severe COVID-19 has been associated with hypoxia, uncontrolled inflammation, and coagulopathy, the mechanisms involved in the progression to severity are poorly understood.

Methods
The virome of tracheal aspirates (TA) from 25 COVID-19 patients under IMV was assessed through unbiased RNA sequencing (RNA-seq), and correlation analyses were conducted using available clinical data. Unbiased sequences from nasopharyngeal swabs (NS) from mild cases and TA from non-COVID patients were included in our study for further comparisons.

Results
We found higher levels and differential expression of human endogenous retrovirus K (HERV-K) genes in TA from critically ill and deceased patients when comparing nasopharyngeal swabs from mild cases to TA from non-COVID patients. In critically ill patients, higher HERV-K levels were associated with early mortality (within 14 days of diagnosis) in the intensive care unit. Increased HERV-K expression in deceased patients was associated with IL-17-related inflammation, monocyte activation, and an increased consumption of clotting/fibrinolysis factors. Moreover, increased HERV-K expression was detected in human primary monocytes from healthy donors after experimental SARS-CoV-2 infection in vitro.

Conclusion
Our data implicate the levels of HERV-K transcripts in the physiopathology of COVID-19 in the respiratory tract of patients under invasive mechanical ventilation.
Cross talk between RNA modification writers and tumor development as a basis for guiding personalized therapy of gastric cancer
Authors: Zhang Shi , Kuang Guanghao , Huang Yao , Huang Xinxin , Wang Weiyu , Wang Guoqiang 
Published: April 2022

AbstractBackgroundGastric cancer (GC) shows high metastasis and low survival. RNA modification writers play critical roles in tumor development. This study examined the clinical significance of RNA modification writers in GC prognosis based on four types of adenosine modifications (m1A, m6A, APA and A-to-I).ResultsWriters demonstrated high mutation and expression in GC patients. Different expressions of 26 RNA modification writers were differentially associated with GC prognosis. High-WM score group appeared worse overall survival, higher immune infiltration and activation of EMT pathways than low-WM score group. WM score was correlated with both miRNAs-targeted signaling pathways and patients’ sensitivity to chemotherapeutic drugs and efficacy of immunotherapy.ConclusionsThis study further revealed the close association between adenosine-related RNA modifications and progression of GC. A cross talk between EMT and RNA modification was identified to be one of the mechanisms underlying GC development. Our WM scoring system could serve as a clinical indicator for predicting GC prognosis. Importantly, the WM score could guide personalized treatments such as chemotherapy and immunotherapy for GC patients.
The association of childhood abuse and neglect with tattoos and piercings in the population: evidence from a representative community survey
Authors: Ernst Mareike , Borkenhagen Ada , Fegert Jörg M. , Brähler Elmar , Plener Paul L. 
Published: April 2022

Abstract
Background
Tattoos and piercings are becoming increasingly popular in many countries around the world. Individuals seeking such body modifications have reported diverse psychological motives. Besides purely superficial considerations, tattoos and piercings can also have a deep, personal meaning. For example, they can mark and support the emotional processing of significant life events, including formative experiences from early childhood. However, there is a lack of studies that examine the links of tattoos and piercings with experiences of childhood abuse and neglect in large, population-based samples.

Methods
We investigated the association of reports of childhood abuse and neglect with the acquisition of body modifications (tattoos and piercings) within a representative German community sample. Survey participants (N = 1060; ages 14–44 years) were questioned whether they had tattoos and piercings and filled out the 28-item Childhood Trauma Questionnaire Short Form (CTQ-SF).

Results
Tattoos and piercings were more common among individuals who reported childhood abuse and neglect. The proportion of participants with tattoos and piercings increased as a function of the severity of all assessed types of abuse and neglect (emotional, physical, and sexual abuse; emotional and physical neglect). In logistic regression analyses which included the covariates age, gender, education, and income, the sum of significant kinds of childhood abuse and neglect was positively related to having tattoos and/or piercings (OR = 1.37 [95% CI 1.19–1.58]).

Conclusions
The results corroborate previous research indicating that body modifications could have special significance for individuals who have survived adversity, in particular interpersonal trauma at the hands of caregivers. These findings could inform screening procedures and low-threshold access to psychotherapeutic care.
The regulatory properties of anger under different goal orientations: the effects of normative and outcome goals
Authors: Antoniou Faye , AlKhadim Ghadah , Stamovlasis Dimitrios , Vasiou Aikaterini 
Published: April 2022

AbstractBackgroundThe present study aimed to evaluate the self-regulatory properties of anger on the performance of individuals under various motivational dispositions using an experimental design.MethodsThe participants were 99 university students who participated in response to extra credit. The performance of the participants was evaluated using the Tower of Hanoi task. Their anger was measured using a facial expression recognition system and arousal was assessed using a heart-rate monitoring device. Two motivational dispositions were assessed: performance goals with normative evaluative standards and performance goals with a focus on outcomes.ResultsThe results indicated that a nonlinear function explained the relationship between anger, arousal, and achievement under different goal conditions. Specifically, the Cusp Catastrophe Model showed that anger levels beyond a critical point were associated with the unpredictability of performance during the normative goal condition, suggesting that anger disturbed the relationship between arousal and achievement. Interestingly, a linear model was relevant for explaining the same relationships during the outcome goal condition.ConclusionThus, this study concluded that anger plays a more salient role when coupled with the pressures arising from employing interpersonal evaluative standards.
An analysis of the appearance characteristics of Korean ceramics per era through statistical analysis of metadata annotated with a visual element classification system of ceramics
Authors: Yi Ji Hyun , Lee Hyunsoo , Kim Songei 
Published: April 2022

Abstract
This study is to create metadata with a ceramic visual element classification system, such as color, form, material, and pattern, and then to analyze the visual characteristics of Korean ceramics by era through this metadata statistical analysis. To achieve this, first, the visual element classification system for ceramics was established. Second, 7,346 ceramic photos were acquired and annotated using the visual element classification system to create metadata. Third, through statistical analysis of the metadata, the preferred visual elements in each era were organized, and their characteristics were analyzed. In particular, the differences in form implementation, color technology, and pattern representation, which vary depending on material properties, were identified. Through this study, the flow of visual elements of Korean ceramics and the reason for each type of appearance and production method could be comprehended more systematically.
Interpretation of gravity–magnetic anomalies to delineate subsurface configuration beneath east geothermal province along the Mahanadi rift basin: a case study of non-volcanic hot springs
Authors: Basantaray Aurobindo Kumar , Mandal Animesh 
Published: April 2022

AbstractGravity and magnetic studies have been carried out over a non-volcanic hot spring zone consisting of Atri and Tarabalo hot springs along the intracontinental Mahanadi rift basin to delineate the subsurface structures and to understand their effect on the geothermal activities over a stable continental region. Calculated gravity and magnetic anomaly maps unveil the presence of hot springs along Mahanadi fault. The four-layer subsurface configuration as observed using radially averaged power spectrum analysis and 3D Euler solutions of both gravity and magnetic data indicates occurrence of multi-phases sedimentation and tectonic events. 2D forward, 2D inverse, and 3D inverse residual gravity models have delineated high-density igneous intrusive bodies surrounded by comparatively less dense Khondalites and Charnockites rich altered zones. The sharp high to low density transition zones are identified as the regional Mahanadi fault. The India–Antarctica rifting, existence of two hot springs along the Mahanadi fault of the rifted basin, and similarity in water chemistry strongly indicates an interconnection between these two hot springs. Igneous intrusions and radiogenic element-rich metamorphosed shallow formations combinedly acting as the heat source. Deciphered altered zone, deeper intrusion and deeply connected regional fault along the hot springs confirmed that this regional fault is providing the major pathway for water circulation through radioactive element-rich altered zones while the local and shallow fractures connecting the Mahanadi fault feed the hot springs of the study area.
Community-based exercise programs incorporating healthcare-community partnerships to improve function post-stroke: feasibility of a 2-group randomized controlled trial
Authors: Aravind Gayatri , Bashir Kainat , Cameron Jill I. , Howe Jo-Anne , Jaglal Susan B. , Bayley Mark T. , Teasell Robert W. , Moineddin Rahim , Zee Joanne , Wodchis Walter P. , Tee Alda , Hunter Susan , Salbach Nancy M. 
Published: April 2022

AbstractBackgroundDespite the potential for community-based exercise programs supported through healthcare-community partnerships (CBEP-HCPs) to improve function post-stroke, insufficient trial evidence limits widespread program implementation and funding. We evaluated the feasibility and acceptability of a CBEP-HCP compared to a waitlist control group to improve everyday function among people post-stroke.MethodsWe conducted a 3-site, pilot randomized trial with blinded follow-up evaluations at 3, 6, and 10 months. Community-dwelling adults able to walk 10 m were stratified by site and gait speed and randomized (1:1) to a CBEP-HCP or waitlist control group. The CBEP-HCP involved a 1-h, group exercise class, with repetitive and progressive practice of functional balance and mobility tasks, twice a week for 12 weeks. We offered the exercise program to the waitlist group at 10 months. We interviewed 13 participants and 9 caregivers post-intervention and triangulated quantitative and qualitative results. Study outcomes included feasibility of recruitment, interventions, retention, and data collection, and potential effect on everyday function.ResultsThirty-three people with stroke were randomized to the intervention (n= 16) or waitlist group (n= 17). We recruited 1–2 participants/month at each site. Participants preferred being recruited by a familiar healthcare professional. Participants described a 10- or 12-month wait in the control group as too long. The exercise program was implemented per protocol across sites. Five participants (31%) in the intervention group attended fewer than 50% of classes for health reasons. In the intervention and waitlist group, retention was 88% and 82%, respectively, and attendance at 10-month evaluations was 63% and 71%, respectively. Participants described inclement weather, availability of transportation, and long commutes as barriers to attending exercise classes and evaluations. Among participants in the CBEP-HCP who attended ≥ 50% of classes, quantitative and qualitative results suggested an immediate effect of the intervention on balance, balance self-efficacy, lower limb strength, everyday function, and overall health.ConclusionThe CBEP-HCP appears feasible and potentially beneficial. Findings will inform protocol revisions to optimize recruitment, and program and evaluation attendance in a future trial.Trial registrationClinicalTrials.gov,NCT03122626. Registered April 21, 2017 — retrospectively registered.
The Stoop-Squat-Index: a simple but powerful measure for quantifying whole-body lifting behavior
Authors: Schmid Stefan 
Published: April 2022

Abstract
Background
Most of the studies evaluating lifting behavior only focus on very localized parameters such as lumbar spine flexion, while evaluations of whole-body strategies are largely lacking. To enable relatively simple evaluations of whole-body strategies, this study aimed at developing a novel index for quantifying the stoop-squat behavior, and to establish normative values of the index for healthy pain-free adults.

Methods
A novel index, the Stoop-Squat-Index, was developed, which describes the proportion between trunk forward lean and lower extremity joint flexion, with possible values ranging from 0 (full squat lifting) to 100 (full stoop lifting). To enable the interpretation of the index in a real-life setting, normative values for lifting a moderately-weighted object (15-kg-box) with a full squat and a full stoop technique were established using motion capture data from 30 healthy pain-free individuals that underwent motion analysis of squat and stoop lifting in the context of a previously conducted study.

Results
The results showed mean index values of lower than 30 and higher than 90 for the most relevant phases of the squat and stoop movements, respectively, with mean index values differing significantly from each other for the full duration of the lifting phases.

Conclusions
The main advantages of the index are that it is simple to calculate and can not only be derived from motion capture data but also from conventional video recordings, which enables large-scale in-field measurements with relatively low expenditure. When used in combination with lumbar spine flexion measurements, the index can contribute important information, which is necessary for comprehensively evaluating whole-body lifting strategies and to shed more light on the debate over the connection between lifting posture and back complaints.
Virulence effect of Metarhizium anisopliae (Met.) and Beauveria bassiana (Bals.) fungi against the peach fruit fly, Bactrocera zonata (Saunders) (Diptera: Tephritidae)
Authors: El-Gendy Ismail R. , Zawrah Mohamed F. M. , El-Banobi Mona I. 
Published: April 2022

Abstract
Background
The peach fruit fly, Bactrocera zonata (Saunders) (Diptera: Tephritidae), is a key pest of fruits in Egypt. Insect-pathogenic fungi are one of the biocontrol agents that increasingly substitute the traditional pesticides to overcome pesticide risks. Therefore, the present study aims to assess the fungal virulence of Beauveria bassiana (Balsamo) and Metarhizium anisopliae (Metchnikoff) against B. zonata pupae. Also, extended pathogenicity effect of these fungi on adult flies was studied.

Results
The results showed that M. anisopliae fungus had more pathogenicity to B. zonata pupae on the 2nd, 3rd, and 5th days post-treatment than B. bassiana. Pathogenicity fungal effects of treated larvae extended to the surviving adults. Fungal concentration and post-exposure interval reversely impacted the pupae by 63.88 and 63.59% mortality in the case of M. anisopliae and B. bassiana, respectively. The lethal concentration of treated fly by M. anisopliae (LC50 = 9.5 × 106 conidia/ml and LC90 = 9.9 × 107 conidia/ml) was lower than that of B. bassiana (LC50 = 5.1 × 107 conidia/ml and LC90 = 1.9 × 109 conidia/ml). Median lethal time (LT50) value was fungal species-dependent, and concentration. Metarhizium anisopliae was more virulent than B. bassiana; the lowest LT50 value was 9.48 days by M. anisopliae and 13.33 days by B. bassiana, depending on the fungal tested concentration of 2.3 × 106 conidia/ml.

Conclusions
The tested entomopathogenic fungi could be considered promising biocontrol agents against B. zonata and could be used for fly suppression through soil application in IPM programs.
COVID-19 vaccine acceptance and perceptions among dental teaching staff of a governmental university in Egypt
Authors: Sharaf Mariam , Taqa Omar , Mousa Haneen , Badran Amira 
Published: April 2022

Abstract
Background
Vaccine acceptance among healthcare workers (HCWs) is an important determinant of its acceptance among the general population. Dentists are an essential group of HCWs who are at an increased risk of COVID-19 infection. This study aimed to assess vaccine acceptance and its determinants among a group of dental teaching staff in Egypt.

Methods
An Internet-based cross-sectional study was conducted where the dental teaching staff of a governmental university in Egypt were targeted using total population sampling. Data was collected on socio-demographics, attitudes towards COVID-19, risk perception, general attitudes towards vaccination, vaccine acceptance, and concerns about COVID-19 vaccines, along with barriers and motivators to vaccination. Multivariate regression was done to determine factors significantly associated with unwillingness to receive COVID-19 vaccine.

Results
A total of 171 dental faculty members participated in the study. At the time of data collection (August 2021–October 2021), 45.6% of the dental teaching staff were willing to receive the vaccine, while 46.7% were against vaccination, and 7.6% were vaccine hesitant. Female gender, not having a private practice, not intending to travel internationally, having anyone sick in the immediate social circle, and being more anxious about COVID-19 were significantly associated with unwillingness to receive the COVID-19 vaccine.

Conclusion
At the time of conducting this study (August 2021–October 2021), less than half of the participating dental teaching staff in the studied Egyptian university were willing to receive the COVID-19 vaccine. Findings of the current study can guide Egyptian health authorities to adopt strategies that correct misconceptions among HCWs, educate them and build their trust in the efficacy and safety of COVID-19 vaccines, which can ultimately increase its acceptance in the general population.
Feasibility study in assessment of congenital cardiovascular malformation by recent technique of fetal cardiac MR imaging
Authors: Hassan Hend Galal Eldeen Mohamed Ali , Habeeb Nevin M. M. , Ibrahim Ahmed Samir , Megahed Shimaa Rashad , Yassin Aya 
Published: April 2022

Abstract
Background
Abnormalities of the cardiovascular system are the most common congenital diseases in the fetus and the first cause of infant mortality. Echocardiography is still the method of choice to visualize the fetal cardiac cardiovascular abnormalities, yet cardiovascular magnetic resonance (CMR) is relatively unaffected by maternal and fetal conditions such as maternal obesity, uterine myoma, twins, oligohydramnios, fetal position and rib calcification, which particularly impair sonographic visualization of the fetal heart. Fetal cardiac MR imaging is a novel MRI technique which can provide valuable information that could add to the prenatal diagnosis and evaluation of cardiac and most of extra-cardiac anomalies. In this work, we aimed to highlight the advantage of FCMRI over fetal echocardiography in assessment of fetal congenital cardiac anomalies.

Results
Fifty-Two fetuses with suspected or diagnosed congenital cardiac anomalies. All cases underwent detailed history taking, underwent fetal echocardiography using suitable curvilinear probe and performed according to standard protocol, then fetal cardiac MR was done with Balanced fast field echo, Black blood single shot, white blood Cine, Real-time 3D dynamic sequences, images were acquired in the transverse, four-chamber, short-axis, coronal and oblique sagittal views. Findings of fetal echocardiography were compared with that of cardiac MRI and with standard post-natal echocardiography. Prenatal Echo and fetal cardiac MRI showed significant moderate agreement between the two modalities in the detection of different congenital cardiac anomalies, Kappa test: 0.500; p value 0.021. Fetal MRI had a significant role in detection of extra cardiac anomalies in most cases. Comparing to gold standard post-natal echo. Accuracy of fetal CMRI is 95.5% and of fetal Echo is 86.4% regarding overall cardiac anomalies:

Conclusion
Fetal cardiac MR imaging as an adjunct to fetal echocardiography may provide valuable information that could add to the prenatal diagnosis and evaluation of cardiac and most of extra cardiac anomalies.
Estimation of horizontal stresses from wellbore failures in strike-slip tectonic regime: A case study from the Ordovician reservoir of the Tinzaouatine field, Illizi Basin, Algeria
Authors: Baouche Rafik , Sen Souvik , Feriel Hadj Arab , Radwan Ahmed E. 
Published: April 2022

We present a geomechanical analysis of the Ordovician reservoir from the Tinzaouatine field situated in the prolific Illizi Basin, eastern Algeria. The sandstone reservoir has a hydrostatic pore pressure gradient (9.95 MPa/km). We analyzed a cumulative of 300 m of acoustic image log data and identified the coexistence of B-quality extensive drilling-induced tensile failures (DITFs) and compressive failures, i.e., breakouts (BOs), indicating a mean maximum horizontal stress ([Formula: see text]) orientation of N140°E. We used a combined BO and DITF-based solution to estimate horizontal stress magnitudes when the two failure types coexist. Based on the C-quality minifrac measurements, we interpreted the minimum horizontal stress ([Formula: see text]) gradient as 17.4–17.47 MPa/km, whereas the new approach indicates an [Formula: see text] range of 17.31–18.67 MPa/km. Using the BO width and DITF-based approaches, we inferred an [Formula: see text] gradient range of 28.37–38.59 MPa/km within the studied reservoir. Based on the relative stress magnitudes, we infer a strike-slip tectonic stress regime in the studied field.
Severe Hypercalcemia From Inhalation Pneumonitis via Activation of 1,25 Dihydroxyvitamin D
Authors: Rosenstein Kyle , Kern Philip A 
Published: April 2022

Abstract
Among the many causes of hypercalcemia are inflammatory conditions, particularly involving granulomatous disease. We present a case of a previously healthy woman who arrived at the emergency department with severe symptomatic hypercalcemia. Workup revealed elevated levels of 1,25-dihydroxyvitamin D along with pneumonitis on computed tomography (CT) imaging. The patient revealed frequent use of eucalyptus oil in her home essential oil diffuser and after removal of the offending agent her hypercalcemia, elevated 1,25-dihydroxyvitamin D, and pneumonitis on CT imaging all resolved.