bluuebunny/crossref_metadata_2025_split huggingface dataset:
A step back to move forward: a geological re‐evaluation of the El Castillo Cave Middle Palaeolithic lithostratigraphic units (Cantabria, northern Iberia)
Authors: Martín‐Perea David M. , Maíllo‐Fernández José‐Manuel , Marín Juan , Arroyo Xabier , Asiaín Raquel 
Published: August 2022

AbstractEl Castillo Cave is one of the most important sites for understanding the Middle and Upper Palaeolithic in Europe. Despite its importance, the absence of a widely used stratigraphic section with detailed lithostratigraphic descriptions and correlations between the different geological and archaeological interpretations has led to confusion in the correct identification of lithostratigraphic units in the lowermost, Middle Palaeolithic sequence. This study establishes a new lithostratigraphic framework for the site, which can be accurately correlated to previous geological and archaeological studies and generates a solid working basis for framing the Mousterian of El Castillo Cave in the Cantabrian region and southwestern Europe. The geological re‐evaluation of Unit XX (‘Mousterian Alpha’) has expanded its chronology, now ranging from 49 130–43 260 cal bp to 70 400 ± 9600 bp. Unit XXII (‘Mousterian Bet’) would consequently yield an age older than 70 400 ± 9600 bp and younger than the underlying speleothem (Unit XXIIIb), dated to 89 000 +11 000/‐10 000 bp.
Responding to the COVID‐19 public health emergency: The usefulness of an online brief psychological intervention with Italian university students
Authors: Cerutti Rita , Spensieri Valentina , Amendola Simone , Biuso Giuseppe Stefano , Renzi Alessia , Tambelli Renata 
Published: August 2022

AbstractThe COVID‐19 pandemic has brought about new stressors on university students, with a negative impact on their mental health and well‐being. The purpose of this study was to examine the usefulness of a brief psychodynamically oriented intervention on general functioning by investigating changes in symptoms of depression, anxiety, hopelessness, and burnout. The sample was comprised of 67 university students (22.4% males), with a mean age of 23.27 (standard deviation (SD) = 3.27), who asked for psychological help at a psychological university service. Pre‐ and posttreatment data showed a significant improvement in general functioning and symptom reduction due to the psychological intervention. The mean change was very high for depression (d = 1.11) and high for general functioning (d = 0.70) and anxiety (d = 0.69). Our findings showed the importance of considering university students a vulnerable population that requires specific services within the university context and underlined the fact that mental‐health‐promotion policies should be extensively implemented.
Inflammation and cardiovascular status impact midazolam pharmacokinetics in critically ill children: An observational, prospective, controlled study
Authors: Neupane Bikalpa , Pandya Hitesh , Pandya Tej , Austin Rupert , Spooner Neil , Rudge James , Mulla Hussain 
Published: August 2022

AbstractAltered physiology caused by critical illness may change midazolam pharmacokinetics and thereby result in adverse reactions and outcomes in this vulnerable patient population. This study set out to determine which critical illness‐related factors impact midazolam pharmacokinetics in children using population modeling. This was an observational, prospective, controlled study of children receiving IV midazolam as part of routine care. Children recruited into the study were either critically‐ill receiving continuous infusions of midazolam or otherwise well, admitted for elective day‐case surgery (control) who received a single IV bolus dose of midazolam. The primary outcome was to determine the population pharmacokinetics and identify covariates that influence midazolam disposition during critical illness. Thirty‐five patients were recruited into the critically ill arm of the study, and 54 children into the control arm. Blood samples for assessing midazolam and 1‐OH‐midazolam concentrations were collected opportunistically (critically ill arm) and in pre‐set time windows (control arm). Pharmacokinetic modeling demonstrated a significant change in midazolam clearance with acute inflammation (measured using C‐Reactive Protein), cardio‐vascular status, and weight. Simulations predict that elevated C‐Reactive Protein and compromised cardiovascular function in critically ill children result in midazolam concentrations up to 10‐fold higher than in healthy children. The extremely high concentrations of midazolam observed in some critically‐ill children indicate that the current therapeutic dosing regimen for midazolam can lead to over‐dosing. Clinicians should be aware of this risk and intensify monitoring for oversedation in such patients.
A review on effects of human activities on aquatic organisms in the Yangtze River Basin since the 1950s
Authors: Yin Senlu , Yi Yujun , Liu Qi , Luo Qiyong , Chen Kebing 
Published: August 2022

AbstractThe Yangtze River is the longest river in China, with abundant water resources, high water energy reserves, and rich biodiversity. Human activities have greatly changed the hydrology and ecology of the Yangtze River Basin since the 1950s. The aquatic biodiversity in the Yangtze River Basin has declined sharply, while the amount of fishery in the Yangtze River has been maintained due to higher intense of fishing, artificial proliferation intervention, and other factors. Human activities including overfishing, water polluting, damming, reclaiming wetlands, shipping and shoreline development, species introduction, and so forth have had great influence on aquatic ecosystems. This paper also reviewed the measures implemented to protect the aquatic ecosystems of the Yangtze River. By reviewing the evolutionary trend of aquatic organisms in the Yangtze River Basin and the related human activities, this paper helps to better understand the biodiversity of the Yangtze River, and requires more attention on the continuous impact of human activities, as well as the effectiveness of protection measures under the new situation of Yangtze River protection.
Efficient Perovskite Indoor Photovoltaics with Open‐Circuit Voltage of 1.15 V via Collaborative Optimization of CsPbI2Br Layer and Hole Transport Layer
Authors: Jiang Shan , Bai Yinglong , Xu Zhiyang , Wang Fuzhi , Xia Lixing , Yang Yun , Li Chenghao , Tan Zhan'ao 
Published: August 2022

AbstractAll‐inorganic CsPbI2Br perovskite has attracted great attention due to the stable crystal structure and moisture resistance, and its 1.91 eV bandgap is close to the optimal bandgap of indoor artificial light sources, making it be the best candidate for the indoor photovoltaics (IPVs) to power a wide range of internet of things related electronic devices. Herein, we report on the preparation of CsPbI2Br with α‐phase and the improvement of its phase stability by adding lead acetate in the CsPbI2Br precursor. A series of dopant‐free conjugated polymers (P3HT, PBDB‐T, and PM6) with different highest occupied molecular orbital energy levels are introduced as hole transport layers for building IPV devices. The PM6 based devices having better energy alignment with perovskite demonstrate best indoor photovoltaic performance, giving a remarkable open‐circuit voltage of 1.15 V and high fill factor of 81.86% under 1000 lux (330 µW cm−2) light‐emitting diode illumination, and finally realizing a decent power conversion efficiency of 33.68%. Our findings suggest that collaboratively optimize the CsPbI2Br layer and hole transport layer is an effective approach to realize high performance IPVs.
STOPPAGE: Spatio‐temporal data driven cloud‐fog‐edge computing framework for pandemic monitoring and management
Authors: Ghosh Shreya , Mukherjee Anwesha , Ghosh Soumya K. , Buyya Rajkumar 
Published: August 2022

AbstractSeveral global health incidents and evidences show the increasing likelihood of pandemics (large‐scale outbreaks of infectious disease), which has adversely affected all aspects of human lives. It is essential to develop an analytics framework by extracting and incorporating the knowledge of heterogeneous data‐sources to deliver insights for enhancing preparedness to combat the pandemic. Specifically, human mobility, travel history, and other transport statistics have significantly impact on the spread of any infectious disease. This article proposes a spatio‐temporal knowledge mining framework, named STOPPAGE, to model the impact of human mobility and other contextual information over the large geographic areas in different temporal scales. The framework has two key modules: (i) spatio‐temporal data and computing infrastructure using fog/edge based architecture; and (ii) spatio‐temporal data analytics module to efficiently extract knowledge from heterogeneous data sources. We created a pandemic‐knowledge graph to discover correlations among mobility information and disease spread, a deep learning architecture to predict the next hotspot zones. Further, we provide necessary support in home‐health monitoring utilizing Femtolet and fog/edge based solutions. The experimental evaluations on real‐life datasets related to COVID‐19 in India illustrate the efficacy of the proposed methods. STOPPAGE outperforms the existing works and baseline methods in terms of accuracy by (18–21)% in predicting hotspots and reduces the power consumption of the smartphone significantly. The scalability study yields that the STOPPAGE framework is flexible enough to analyze a huge amount of spatio‐temporal datasets and reduces the delay in predicting health status compared to the existing studies.
Three‐dimensional testing of fasteners
Authors: Konertz Dustin , Mahrenholtz Christoph , Mark Peter 
Published: August 2022

AbstractExperimental results of tests to investigate the load‐bearing behavior of anchor channels embedded in concrete and subjected to loads in three‐dimensional (3D) interaction are presented. For testing, a variably adjustable rig is introduced in which arbitrary 3D loads are applied with just one hydraulic cylinder. Investigations focus on concrete failure. The test program includes variable load angles and anchor channels installed at the edges and at corner of concrete prisms. In both configurations a significant impact of the loading direction regarding the channel axis is found. Mathematically interaction is captured with trilinear and Lamè curves. Therein, the experimental findings are reflected by individual model parameters that yield the best fit in regression. For both configurations, an optimal prognosis model is derived which covers all 3D load situations in assured quality. Moreover, the tests prove the general suitability of the developed rig, which thus qualifies for application in other experimental settings.
Cross‐species transmission of feline herpesvirus 1 (FHV‐1) to chinchillas
Authors: Shi Longyan , Huang Shuping , Lu Yuxin , Su Yuqing , Guo Lin , Guo Lijun , Xie Wei , Li Xiang , Wang Yulong , Yang Siyuan , Chai Hongliang , Wang Yajun 
Published: August 2022

AbstractBackgroundHerpesviruses are a class of double‐stranded DNA viruses found in both vertebrates and invertebrates. They are usually highly host‐specific and do not easily spread across species. Chinchillas have gradually entered the Chinese pet market in recent years, but references to viral infections in chinchillas are extremely scarce, and only two reports about the herpesvirus in chinchillas are available at present.ObjectivesThe aim of this study was to present the first report of FHV‐1 infection in chinchillas.MethodsA total of 130 nasopharyngeal swab samples of chinchillas and three nasopharyngeal swabs of domestic cats collected from a chinchillas farm were investigated by nested PCR for FHV‐1.ResultsFour chinchillas were infected with FHV‐1, the positive rate was 3.08% (4/130), and two domestic cats were FHV‐1 positive (2/3). The 253 bp fragments of FHV‐1 gD gene from four chinchillas and two domestic cats were 100% identical, respectively, and the homology between chinchillas and domestic cat was 99.21%, but they all shared nearly 98.81% homology with the reference strain sequences. Phylogenetic tree analysis showed that these four chinchillas strains were clustered together with FHV‐1.ConclusionsThis is the first time that FHV‐1 was detected in chinchillas and suggested chinchillas are susceptible to FHV‐1 and may play a role as a temporary reservoir for FHV‐1.
A narrative literature review on media and maternal health in Africa
Authors: Ohaja Magdalena , Senkyire Ephraim K. , Ewetan Olabanji , Asiedua Ernestina , Azuh Dominic 
Published: August 2022

AbstractHealth communication is a strategy used to disseminate health information to individuals and communities to enable them to make decisions that will enhance their health and well‐being. Particularly in the era of digital health, such strategies tend to emphasize health promotion and disease prevention. Access to essential health information is a fundamental aspect of an effective health‐care system and is therefore crucial for achieving universal health coverage and other health‐related sustainable development goals. Traditional media play a crucial role in enhancing maternal and newborn health, which remains a significant challenge in sub‐Saharan Africa. This narrative literature review explores the use of mass media in disseminating maternal health‐related information in Africa. Twenty‐five articles were considered relevant and included in the review. The result is presented under the following themes (1) access to health information, (2) health‐seeking behavior, (3) birth preparedness, and (4) challenges associated with mass media. UNICEF Strategy for Health 2016–2030, African Union agenda 2063, and sustainable development goal #3 informed this review. As a major stakeholder in the African health sectors, the media plays a critical role in tackling systemic health inequities by promoting the sharing of maternal health information with citizens. There is a need for collaboration among all health stakeholders, as well as a sustainable relationship between media practitioners and health authorities for the promotion of improved maternal health in Africa.
News: The Pursuit of Immediacy
Authors: Fisher-Høyrem Stefan 
Published: August 2022

AbstractUnderpinning the Victorian public sphere was a network characterized by an intense pursuit of immediacy. By creating an abstract and ‘empty’ space where the public might observe and participate in ongoing events on a societal scale, this network served to establish public opinion as a source of political legitimacy. The telegraph, the development of professional journalistic skill sets, and the extraction of colonial natural resources made it possible to extend the news network beyond regional and national borders. The uniform typographical ‘form of news’ characterizing Victorian daily newspapers was an effect of specific technological adjustments needed to move newsworthy events across vast distances without interruption or distortion. In this way, the news network mediated a secular time independent of motion.
Iguanas, Isolation, and Ideas
Authors: Chevez Agustin 
Published: August 2022

AbstractI am on a peak-hour, return leg flight from Sydney to Melbourne following a full day of meetings with clients where I shared the findings from our latest workplace design research. The conversations were fruitful, with a particular focus on innovation – a popular topic among organisations. We discussed the ways a workplace could help unearth ideas that organisations intuitively know exist in the ranks of their employees but can be awfully hard to uncover.
Mind Lag
Authors: Chevez Agustin 
Published: August 2022

AbstractI looked through the aeroplane window and I couldn’t believe my eyes when I recognised the route I had taken on my approach to Sydney. I grabbed my phone and took a picture of a distinctive section of the road that I had covered on day 32 of the walk, from Sanctuary Point (covered by the wing on the right) to Bomaderry (under the low-level clouds on the left) indicated with an ‘x’, Fig. 22.1.
A patterns of care analysis of hyperthermia in combination with radio(chemo)therapy or chemotherapy in European clinical centers
Authors: Ademaj Adela , Veltsista Paraskevi D. , Marder Dietmar , Hälg Roger A. , Puric Emsad , Brunner Thomas B. , Crezee Hans , Gabrys Dorota , Franckena Martine , Gani Cihan , Horsman Michael R. , Krempien Robert , Lindner Lars H. , Maluta Sergio , Notter Markus , Petzold Griseldis , Abdel-Rahman Sultan , Richetti Antonella , Thomsen Andreas R. , Tsoutsou Pelagia , Fietkau Rainer , Ott Oliver J. , Ghadjar Pirus , Riesterer Oliver 
Published: August 2022

Abstract
Purpose
The combination of hyperthermia (HT) with radio(chemo)therapy or chemotherapy (CT) is an established treatment strategy for specific indications. Its application in routine clinical practice in Europe depends on regulatory and local conditions. We conducted a survey among European clinical centers to determine current practice of HT.

Methods
A questionnaire with 22 questions was sent to 24 European HT centers. The questions were divided into two main categories. The first category assessed how many patients are treated with HT in combination with radio(chemo)therapy or CT for specific indications per year. The second category addressed which hyperthermia parameters are recorded. Analysis was performed using descriptive methods.

Results
The response rate was 71% (17/24) and 16 centers were included in this evaluation. Annually, these 16 centers treat approximately 637 patients using HT in combination with radio(chemo)therapy or CT. On average, 34% (range: 3–100%) of patients are treated in clinical study protocols. Temperature readings and the time interval between HT and radio(chemo)therapy or CT are recorded in 13 (81%) and 9 (56%) centers, respectively. The thermal dose quality parameter “cumulative equivalent minutes at 43 °C” (CEM43°C) is only evaluated in five (31%) centers for each HT session. With regard to treatment sequence, 8 (50%) centers administer HT before radio(chemo)therapy and the other 8 in the reverse order.

Conclusion
There is a significant heterogeneity among European HT centers as to the indications treated and the recording of thermometric parameters. More evidence from clinical studies is necessary to achieve standardization of HT practice.
Fluid dynamics and blood damage in the dilated ascending aorta after mechanical prosthetic valve implantation: an in vitro study
Authors: Querzoli Giorgio , Badas Maria Grazia , Ferrari Simone , Prost Roberto , Satta Vittorio , Matta Gildo 
Published: August 2022

AbstractThe implantation of aortic valve prostheses is often associated with the dilation of the ascending aorta. It is well known that the modification of the fluid dynamics induced by both the prosthetic valve and aortic dilation may, in turn, promote further vessel remodelling. Besides, when the prosthesis is mechanical, a major concern is the blood cell damage and platelet activation which requires a lifelong anticoagulant therapy, which in turn is an additional significant factor of comorbidity. We analysed in vitro the combined effect of the presence of a bileaflet mechanical aortic valve and the dilation of the aortic root in patient specific laboratory models. Three model aortas with increasing degree of dilation, hosted in a mock loop reproducing the heart flow pulsatility, were investigated. The measurement of the time-resolved velocity field allowed the analysis of the general structure of the flow and shear strain-rate distribution. Additionally, the Blood Damage Indexes (BDIs) for both haemolysis and platelet activation were computed along synthetic particle trajectories. Results suggest that a feedback process can be triggered since the aortic dilation tends to decrease the shear stresses at the walls and favour blood stasis: two factors that are known to promote vessel remodelling. Secondly, the analysis of BDIs shows that aortic dilation significantly increases the damage index for haemolysis, whereas a similar effect is not shown when focusing on platelet activation.
Graphical abstract
Clinical application of transoral and submental thyroidectomy (TOaST): a series of 54 human cases
Authors: Chen Hang , Deng Lijuan , Xu Keyi , Gong Zhixian , Zhu Xiaoping 
Published: August 2022

Abstract

Objective
A new endoscopic thyroidectomy approach—transoral and submental endoscopic thyroidectomy (TOaST)—was applied in clinical practice and considered an improved approach for endoscopic thyroid surgery via the oral approach. This paper discusses the feasibility and effectiveness of this surgical method.

Methods
A retrospective analysis was performed on the clinical data of 54 patients who had undergone TOaST in the thyroid disease center of the First Affiliated Hospital of Nanchang University between December 2020 and December 2021. The surgical data and techniques, complications, and cosmetic outcomes of these patients were studied.

Results
Among the total 54 patients, 23 underwent unilateral subtotal thyroidectomy, 3 patients underwent bilateral subtotal thyroidectomy, 27 with unilateral thyroid cancer underwent affected thyroid + isthmus + central lymph node resection, and only 1 patient underwent total thyroidectomy. The mean operative time was 88.06 ± 12.03 min (range: 65–135 min), the mean intraoperative blood loss was 8.61 ± 4.60 ml (range: 5–20 ml), the mean postoperative drainage volume was 49.96 ± 9.88 ml (range: 30–60 ml), the mean drainage time was 36.61 ± 2.65 h (range: 32–50 h), and the mean length of hospital stay was 46.63 ± 3.28 h (range 45–70 h). One patient experienced transient recurrent laryngeal nerve injury, and another patient experienced transient parathyroid dysfunction; there was no superior laryngeal nerve injury and other complications, such as postoperative subcutaneous hematoma, hypercapnia, mental nerve injury, tracheoesophageal injury, infection, or lymphatic leakage.

Conclusion
TOaST cannot only achieve a good therapeutic effect but also avoid mental nerve injury, reduce the discomfort of the patient’s jaw, obtain a good cosmetic effect, and facilitate the operation of the operator. It is an endoscopic thyroidectomy technique with a certain clinical value.