bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of compounds from chufa (Eleocharis dulcis) peels by widely targeted metabolomics
Authors: Li Guanli , Huang Shuangquan , Li Xiaochun , Luo Yanghe , Nie Hui 
Published: October 2022

AbstractThe Chinese water chestnut (CWC) is among the most widespread and economically important vegetables in Southern China. There are two different types of cultivars for this vegetable, namely, big CWC (BCWC) and small CWC (SCWC). These are used for different purposes based on their metabolic profiles. This study aimed to investigate the metabolite profile of CWC and compare the profiles of peels collected in different harvest years using ultraperformance liquid chromatography/mass spectrometry (UPLC–MS)‐based metabolomics analysis. Three hundred and twenty‐one metabolites were identified, of which 87 flavonoids, 25 phenylpropanoids, and 33 organic acids and derivatives were significantly different in the content of the two varieties of BCWC and SCWC. The metabolite profiles of the two different cultivars were distinguished using principle component analysis (PCA) and orthogonal projections to latent structures discriminant analysis, and the results indicated differences in the metabolite profile of Eleocharis dulcis (Burm. f.) Trin. ex Hensch. Three isomers of hydroxycoumarin, namely, O‐feruloyl‐4‐hydroxycoumarin, O‐feruloyl‐3‐hydroxycoumarin, and O‐feruloyl‐2‐hydroxycoumarin, exhibited increased levels in BCWC, while p‐coumaric acid and vanillic acid did not show any significant differences in their content in BCWC and SCWC peels. This study, for the first time, provides novel insights into the differences among metabolite profiles between BCWC and SCWC.
Internet of Things and healthcare system: A systematic review of ethical issues
Authors: Zakerabasali Somayyeh , Ayyoubzadeh Seyed Mohammad 
Published: October 2022

AbstractBackground and AimsThe Internet of Things (IoTs) is a set of connected objects and devices that share data and pursue a common goal in different areas. IoT technology can significantly help the healthcare system by enabling the monitoring of elderly and chronic disease patients. Along with the growth of this technology, its challenges and limitations such as Connectivity, Compatibility, Standards, cost, legal, and ethical also increase. One of the most critical and challenging issues in the IoT is ethical issues. This study aims to explore the key ethical aspects of the IoT and Categorize them based on the executive phases of IoT in healthcare.MethodsThe current study was conducted in two phases using the mixed‐method approach. In the first phase, a systematic review was conducted in relevant databases to identify ethical issues of the IoT. In the second phase, a focus group discussion was conducted to classify the extracted data elements based on executive phases of IoT by medical informatics experts and computer engineerings.ResultsAmong the 138 papers retrieved through the search strategy, 11 articles were selected, and 12 ethical issues related to IoT were identified. The obtained results revealed the importance of ethical issues of IoT, including security, confidentiality, privacy, anonymity, freedom to withdraw, informed consent, integrity, availability, authorization, access control, censoring, and eavesdropping. They were classified into five main categories of executive phases of IoT based on the five experts’ opinions affiliated with SUMS, including data collection, data storage, data process, data transmission, and data delivery.ConclusionBecause of the key role of the IoT in disease prevention, real‐time tele‐monitoring of patient's functions, testing of treatments, health management, and health research, considering the risks relating to Health care and patient data is essential. Moreover, health policymakers should be aware of the ethical commitment to using IoT technology.
Urbanization of grasslands in the Denver area affects streamflow responses to rainfall events
Authors: Wilson Stacy , Bhaskar Aditi S. , Choat Benjamin , Kampf Stephanie , Green Timothy R. , Hopkins Kristina G. 
Published: October 2022

AbstractA thorough understanding of how urbanization affects stream hydrology is crucial for effective and sustainable water management, particularly in rapidly urbanizing regions. This study presents a comprehensive analysis of changes in streamflow response to rainfall events across a rural to urban gradient in the semi‐arid area of Denver, Colorado. We used 8 years of April to October instantaneous streamflow data in 21 watersheds ranging in size from 0.8 to 90 km2 and with impervious areas ranging from 1% to 47%. With these data, we applied a semi‐automated method to identify a total of 2877 streamflow responses, which were analysed for event‐based metrics of peak flow, runoff depth, runoff to rainfall ratio, time to peak, duration and number of streamflow responses to rainfall events. We also determined whether streamflow responses could be predicted by a precipitation threshold. Watersheds with >10% impervious cover had a precipitation threshold of 1–2 mm/hr needed to produce a streamflow response, compared to thresholds of 4–36 mm/hr for watersheds with less than 10% impervious surface cover. This lower precipitation threshold in more impervious watersheds led to more frequent streamflow responses. On average, streamflow responses had shorter duration and higher peak flows in watersheds with more impervious surface cover. In contrast to other regions, runoff depth, runoff to rainfall ratio and time to peak either gave mixed results or did not vary significantly with imperviousness. These alterations in streamflow response to rainfall events indicate the specific ways that urban development changes how streams respond to rain events in a semi‐arid setting. This work points to the need for local adaptation of stormwater management to mitigate the effects of streamflow changes with urbanization.
Modelling electrical conductivity variation using a travel time distribution approach in the Duck River catchment, Australia
Authors: Riazi Zahra , Western Andrew W. , Bende‐Michl Ulrike 
Published: October 2022

AbstractSolute dynamics depend strongly on hydrologic flow paths and transit times within catchments. In this paper, we use a travel time tracking method to simulate stream salinity (as measured by electrical conductivity) in the Duck River catchment, NW Tasmania, Australia. The study couples storage selection function transit time modelling with two alternate approaches to model electrical conductivity (EC). The first approach assumes the catchment has a cyclic salt balance (i.e., rainfall source, stream flow sink) that is in dynamic equilibrium and evapoconcentration of salt is the only process changing concentration. The second approach assumes that the salinity of water in catchment storages is a function of water age in those stores, without explicitly simulating salt mass balance processes. The paper compares these alternate approaches in terms of EC simulation performance, simulated stream water age distributions, and simulated storage age distributions. A split sample calibration‐validation analysis was conducted using the 2008 and 2009 water years. Both EC simulation approaches reproduced stream EC variations very well under both calibration and validation. The simulations using the age‐related EC simulation approach produced less biased results and, consequently, higher model coefficient of efficiency for validation periods. This approach also produced more consistent model parameter estimates between periods. There were systematic differences in the resultant age distributions between models, particularly for the solute balance‐based simulations where parameters (catchment storage size) changed more between the two calibration periods. The effect of time varying versus static storage selection functions were compared, with clear evidence that time varying storage selection functions with parameters linked to catchment conditions (flow) are essential for adequate simulation of EC dynamics during flow events.
Study to determine efficacy of urinary HPV 16 & HPV 18 detection in predicting premalignant and malignant lesions of uterine cervix
Authors: John Julie Hansa , Halder Ajay , Purwar Shashank , Pushpalatha Kameshwarachari , Gupta Priyal , Dubey Pankhuri 
Published: October 2022

AbstractObjectivesTo evaluate clinical performance and diagnostic accuracy of urinary HPV for non‐invasive screening of high‐grade precancerous and cancerous cervical lesions in a visual inspection under acetic acid (VIA) ‐positive cohort.MethodThe study included 180 women aged 35–65 years, who were VIA positive in a colposcopy clinic. All participants had the initial stream of a random urine sample tested for the presence of high‐risk HPV (hrHPV) types 16 and 18 and acetowhite lesions were biopsied per protocol. Concordance analysis was conducted to assess agreement between detection of hrHPV in urine and the presence of premalignant and malignant lesions in cervix on histopathology. Measures of diagnostic accuracy were estimated to evaluate the performance of urinary HPV against histopathology (reference standard).ResultsSubstantial agreement between urinary HPV detection and histopathology was found (Cohen's κ is 0.696, P ≤ 0.001), with an agreement in 88.9% of the cases and disagreement in 11.1%. The diagnostic performance of urinary HPV in predicting the presence of a high‐grade precancerous or cancerous lesion was as follows: sensitivity 67%, specificity 97%, positive predictive value 89%, and negative predictive value 88.8%.ConclusionHPV DNA detection from urine has good concordance with the histopathology for detection of precancerous and cancerous lesions of the cervix. Further studies on optimization of urine sampling and processing techniques are warranted.
Osseointegration behavior of carbon fiber reinforced polyetheretherketone composites modified with amino groups: An in vivo study
Authors: Wang Junyan , Yu Wanqi , Shi Ruining , Yang Shihui , Zhang Jingjie , Han Xiao , Zhou Zhe , Gao Weijia , Li Yongli , Zhao Jinghui 
Published: October 2022

AbstractPolyetheretherketone (PEEK) has become increasingly popular in dentistry and orthopedics due to its excellent chemical stability, reliable biosafety, and low elastic modulus. However, PEEK's biomechanical strength and bioactivity are limited and need to be increased as an implant material. The previous study in vitro has shown that the amino‐functionalized carbon fiber reinforced PEEK (A‐30%‐CPEEK) possessed enhanced mechanical property and bioactivity. This study aims to evaluate the effect of amino groups modification on the osseointegration behavior of carbon fiber reinforced PEEK (30%‐CPEEK) in rabbits. Herein, 30%‐CPEEK and A‐30%‐CPEEK implant discs were implanted in rabbit skulls for 5 weeks, with pure titanium implants serving as a control. The bone‐forming ability and osseointegration in vivo were systematically investigated by micro‐computed tomography analysis, scanning electron microscope observation, and histological evaluation. Our results showed that all detection parameters were significantly different between the A‐30%‐CPEEK and 30%‐CPEEK groups, favoring those in the A‐30%‐CPEEK, whose appraisal parameters were equal to or better than pure titanium. Therefore, this study supported the importance of amino groups in facilitating the new bone formation and bone‐implant integration, suggesting that A‐30%‐CPEEK with enhanced osseointegration will be a promising material for dental or orthopedic implants.
The Efficacy and Safety of Abaloparatide-SC in Men With Osteoporosis: A Randomized Clinical Trial
Authors: Czerwinski Edward , Cardona Jose , Plebanski Rafal , Recknor Chris , Vokes Tamara , Saag Kenneth G , Binkley Neil , Lewiecki E Michael , Adachi Jonathan , Knychas Dorota , Kendler David , Orwoll Eric , Chen Yinzhong , Pearman Leny , Li Y Heather , Mitlak Bruce 
Published: October 2022

ABSTRACT
Abaloparatide significantly increased bone mineral density (BMD) in women with postmenopausal osteoporosis and decreased risk of vertebral, nonvertebral, and clinical fractures compared with placebo. The Abaloparatide for the Treatment of Men with Osteoporosis (ATOM; NCT03512262) study evaluated the efficacy and safety of abaloparatide compared with placebo in men. Eligible men aged 40 to 85 years with osteoporosis were randomized 2:1 to daily subcutaneous injections of abaloparatide 80 μg or placebo for 12 months. The primary endpoint was change from baseline in lumbar spine BMD. Key secondary endpoints included BMD change from baseline at the total hip and femoral neck. A total of 228 men were randomized (abaloparatide, n = 149; placebo, n = 79). Baseline characteristics were similar across treatment groups (mean age, 68.3 years; mean lumbar spine BMD T-score, −2.1). At 12 months, BMD gains were greater with abaloparatide compared with placebo at the lumbar spine (least squares mean percentage change [standard error]: 8.48 [0.54] versus 1.17 [0.72]), total hip (2.14 [0.27] versus 0.01 [0.35]), and femoral neck (2.98 [0.34] versus 0.15 [0.45]) (all p &lt; 0.0001). The most common (≥5%) treatment-emergent adverse events were injection site reaction, dizziness, nasopharyngitis, arthralgia, bronchitis, hypertension, and headache. During 12 months of abaloparatide treatment, men with osteoporosis exhibited rapid and significant improvements in BMD with a safety profile consistent with previous studies. These results suggest abaloparatide can be considered as an effective anabolic treatment option for men with osteoporosis. © 2022 Radius Health Inc and The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Abstract
Change from baseline in bone mineral density. *p &lt; 0.0001. In men with osteoporosis, least squares mean percentage change (standard error) from baseline in lumbar spine BMD at 12 months was 8.48% (0.54%) with abaloparatide compared with 1.17% (0.72%) with placebo (p &lt; 0.0001).
Discussing proximal pasts and far futures
Authors: Weingarten Evan , Berger Jonah 
Published: October 2022

AbstractConsumers often share word of mouth, and such interpersonal communication shapes attitudes and purchases. But while some research has examined what consumers talk about, there has been less attention to when consumers discuss. How does the distance from now (i.e., whether something is temporally near or far away) shape the likelihood of discussion? And might the effect of temporal distance on word of mouth vary based on whether those things happened in the past or will happen in the future? Five studies, including analyses of thousands of social media posts, address these questions. They suggest that consumers tend to talk about temporally near things, but that this is moderated by whether they are talking about the past or future (i.e., consumers talk about more temporally distant things when talking about the future). Accessibility seems to play an important role in these effects. While temporally near things tend to be more accessible, on average, goals and plans are more likely to remain active in the future, which shapes what gets discussed. These findings have implications for understanding drivers of word of mouth, how time shapes consumer behavior, and how companies can more effectively manage interpersonal communication.
Chondrocranial variation in chicken domestication
Authors: Núñez‐León Daniel , Nagashima Hiroshi , Sánchez‐Villagra Marcelo R. 
Published: October 2022

AbstractThe chondrocranium is a key structure of the skull, but our knowledge of its embryonic development is based mostly on investigations of few stages across taxa. Variation of chondrocranial features is known across species, but little is known about intraspecific variation, or its evolution in the context of domestication. Here, we investigated two specific structures of the chondrocranium in three windows of embryonic development. The anatomy of one of these structures was also compared among adult skulls of chickens and their wild ancestor (red junglefowl [RJF]). The proccesus tectalis and the prenasal process, along with the surrounding area of the orbitonasal foramina, presented variation throughout the ontogeny and in the adults. The processus tectalis showed distinct variation from the earliest stage studied to the adult. The numbers of orbitonasal foramina were also found to be variable in the ancestor and breeds studied. Furthermore, during early embryonic development, the prenasal process is similar across breeds and RJF, but later in embryonic development this structure presents variable states. The embryonic and adult variation found herein could be an example of intraspecific variation under domestication, resulting from different types of tissue interrelationship during development.
Viral load decrease in SARS‐CoV‐2 BA.1 and BA.2 Omicron sublineages infection after treatment with monoclonal antibodies and direct antiviral agents
Authors: Mazzotta Valentina , Cozzi Lepri Alessandro , Colavita Francesca , Rosati Silvia , Lalle Eleonora , Cimaglia Claudia , Paulicelli Jessica , Mastrorosa Ilaria , Vita Serena , Fabeni Lavinia , Vergori Alessandra , Maffongelli Gaetano , Carletti Fabrizio , Lanini Simone , Caraffa Emanuela , Milozzi Eugenia , Libertone Raffaella , Piselli Pierluca , Girardi Enrico , Garbuglia AnnaRosa , Vaia Francesco , Maggi Fabrizio , Nicastri Emanuele , Antinori Andrea ,   INMI COVID‐19 Outpatient Treatment Study Group
Published: October 2022

AbstractThe efficacy on the Omicron variant of the approved early coronavirus disease‐2019 (COVID‐19) therapies, especially monoclonal antibodies, has been challenged by in vitro neutralization data, while data on in vivo antiviral activity are lacking. We assessed potential decrease from Day 1 to Day 7 viral load (VL) in nasopharyngeal swabs of outpatients receiving Sotrovimab, Molnupiravir, Remdesivir, or Nirmatrelvir/ritonavir for mild‐to‐moderate COVID‐19 due to sublineages BA.1 or BA.2, and average treatment effect by weighted marginal linear regression models. A total of 521 patients (378 BA.1 [73%], 143 [27%] BA.2) received treatments (Sotrovimab 202, Molnupiravir 117, Nirmatrelvir/ritonavir 84, and Remdesivir 118): median age 66 years, 90% vaccinated, median time from symptoms onset 3 days. Day 1 mean VL was 4.12 log2 (4.16 for BA.1 and 4.01 for BA.2). The adjusted analysis showed that Nirmatrelvir/ritonavir significantly reduced VL compared to all the other drugs, except versus Molnupiravir in BA.2. Molnupiravir was superior to Remdesivir in both BA.1 and BA.2, and to Sotrovimab in BA.2. Sotrovimab had better activity than Remdesivir only against BA.1. Nirmatrelvir/ritonavir showed the greatest antiviral activity against Omicron variant, comparable to Molnupiravir only in the BA.2 subgroup. VL decrease could be a valuable surrogate of drug activity in the context of the high prevalence of vaccinated people and low probability of hospital admission.
The relationship between length of stay in intensive care unit and Tpeak‐Tend and Tpeak‐Tend/QTc ratio in COVID 19 patients with acute coronary syndrome
Authors: Altuntas Emine , Cetın Sükrü , Karabay Kanber Ocal , Bagırtan Bayram , Celebı Filiz 
Published: October 2022

AbstractBackgroundPatients with coronavirus disease 2019 (COVID‐19) can develop cardiac injury resulting in cardiac arrhythmias, myocarditis, and acute coronary syndrome (ACS). In this study, we aimed to investigate whether COVID‐19 infection affects ventricular repolarization parameters such as Tpeak‐Tend interval (Tp‐e), QT interval, corrected QT (QTc), Tp‐e/QT, and Tp‐e/cQT in patients with ACS.MethodsThe study consisted of two groups. The first group included patients with ACS and COVID‐19 (Group 1) (n = 50). Polymerase chain reaction test positive patients were enrolled. The second group included patients with only ACS (Group 2) (n = 100). The risk of ventricular arrhythmias was evaluated on the basis of the measured electrocardiographic Tp‐e and QT interval, and QTc, Tp‐e/QT, and Tp‐e/QTc values.ResultsTp‐e interval, QTc, and Tp‐e/QTc were significantly higher in the group1 than group 2 (p < .001, p < .018, and p < .001, respectively). Significant positive correlations were found between Tp‐e, D‐dimer level, and C‐reactive protein (CRP) level in the group1 (p = .002, p = 0 .03, and p = .021, respectively). Univariate and multivariate regression analyses revealed that Tp‐e was one of the independent predictor of length of stay in the intensive care unit (ICU). (B = 1.662, p = .006 and B = 1.804, p = .021, respectively).ConclusionsIn the patients with ACS, COVID‐19 infection caused increases in QTc, Tp‐e, and Tp‐e/QTc ratio. In addition, age and prolonged Tp‐e were found to be independent predictors of prolonged ICU stay.
Atrial late potentials are associated with atrial fibrillation recurrence after catheter ablation
Authors: Saito Daiki , Fukaya Hidehira , Oikawa Jun , Sato Tetsuro , Matsuura Gen , Arakawa Yuki , Kobayashi Shuhei , Shirakawa Yuki , Ishizue Naruya , Kishihara Jun , Niwano Shinichi , Ako Junya 
Published: October 2022

AbstractBackgroundPrevious studies have identified noninvasive methods for predicting atrial fibrillation (AF) recurrence after catheter ablation (CA). We assessed the association between AF recurrence and atrial late potentials (ALPs), which were measured using P‐wave signal‐averaged electrocardiography (P‐SAECG).MethodsConsecutive patients with paroxysmal AF who underwent their first CA at our institution between August 2015 and August 2019 were enrolled. P‐SAECG was performed before CA. Two ALP parameters were evaluated: the root‐mean‐square voltage during the terminal 20 ms (RMS20) and the P‐wave duration (PWD). Positive ALPs were defined as an RMS20 <2.2 μV and/or a PWD >115 ms. Patients were allocated to either the recurrence or nonrecurrence group based on the presence of AF recurrence at the 1‐year follow‐up post‐CA.ResultsOf the 190 patients (age: 65 ± 11 years, 37% women) enrolled in this study, 21 (11%) had AF recurrence. The positive ALP rate was significantly higher in the recurrence group than in the nonrecurrence group (86% vs. 64%, p = .04), despite the absence of differences in other baseline characteristics between the two groups. In the multivariate analysis, positive ALP was an independent predictor of AF recurrence (odds ratio: 3.83, 95% confidence interval: 1.05–14.1, p = .04).ConclusionsPositive ALP on pre‐CA P‐SAECG is associated with AF recurrence after CA.
Swarming behavior of a novel strain of Brevibacillus thermoruber
Authors: Sakka Kazuo , Kihira Masaki , Kuhara Wataru , Mochida Akihiro , Kimura Tetsuya , Sakka Makiko 
Published: October 2022

AbstractBrevibacillus thermoruber strain Nabari was isolated from compost and identified based on 16 S rRNA gene sequencing and DNA–DNA hybridization using B. thermoruber DSM 7064 T as the standard, despite some differences in their physiological and structural characteristics. When B. thermoruber Nabari was cultivated on various solid media containing 1.5% agar at 60°C, it rapidly propagated over the entire plate. In particular, on R2A‐agar medium, it formed fine dendritic colonies. Macroscopic and microscopic observations of peripheral regions of the colonies indicated that the dendritic patterns were formed by bacterial swarming of some of the cells; large flows of bacterial cell populations were observed in the peripheral regions of the dendritic colonies. The cells were highly flagellated, but no extreme elongation of cells was observed. When B. thermoruber Nabari cells were cultivated at 37°C on R2A‐agar plates, most colonies were nonmotile, but some colonies were motile. For example, a wandering colony moved on the plate and split into two, and then they collided to become one again. Additionally, a simple incubation system was devised to record the movement of colonies at high temperatures in this study while protecting the cameras from thermal damage.