bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attitudes towards death in adolescents hospitalized with depressive disorder
Authors: Bebchuk M. , Dovbysh D. , Timoshenko S. , Rabadanova R. , Zhorina Y. , Diachenko A. , Talmach M. , Fakhretdinova G. 
Published: September 2022

IntroductionThe study of attitudes towards death in patients of different nosological groups is an urgent task for modern science. It becomes especially relevant when working with adolescents with severe depressive disorder: for many of them, thoughts about death in various forms become the main reason for contacting specialists and the most subjectively painful symptom.ObjectivesRevealing the characteristics of attitudes towards death in adolescents with severe depressive disorder.Methods
The study involved 135 adolescents (12-17 years old) with depressive disorder, hospitalized in a psychiatric hospital. Participants completed the following methods: Hamilton Rating Scale for Depression, Columbia Suicide Severity Rating Scale, Death Attitude Profile-Revised, Fear of Personal Death Scale, Death Anxiety Scale.Results

The severity of depressive symptoms is significantly associated with the “death-as-flight” scale (r = 0.639, p = 0.000). The values on the “fear of death” scale are positively associated with the indicators on the scales “death anxiety” (r = 0.432 p = 0.025), “consequences of death for the individual” (r = 0.658, p = 0.000), “transcendental consequences of death” (r = 0.711, p = 0.000), “the consequences of my death for loved ones” (r = 0.496, p = 0.008). Indicators on the “active death search” scale are negatively associated with indicators on the “neutral acceptance of death” scale (r = -0.503, p = 0.007) and positively with the “fear of oblivion” scale (r = 0.432, p = 0.024).ConclusionsThe attitude towards death in adolescents with depressive disorder has a pronounced specificity, which can become one of the targets of psychotherapeutic work.DisclosureNo significant relationships.
A comparison between patients who suffer from major depression and are treated with Esketamine – one group participates in group therapy and the other one does not
Authors: Yaniv H. , Savlev V. 
Published: September 2022

IntroductionMajor depressive disorder is present in approximately 7% of the general population. There are some patients that remain treatment-resistant - patients who were treated with two or more different medications and did not demonstrate any improvement in their mental state. These patients can be treated with a new treatment – Esketamine. The recommended Esketamine treatment protocol includes 8-treatment sessions, each session lasts about two hours. In our clinic, we added a therapy group after each treatment. The therapy group is led by two co-therapist and lasts 30 minutes. The patients are invited to share their experiences from the session, their thoughts and emotions.ObjectivesThe study that we will present was conducted in the Esketamine treatment unit at a psychiatric hospital. There were two groups - 1. A group whose treatment included a therapeutic group at the end of each Esketamine treatment (n=30); 2. A group whose treatments did not include a therapeutic group at the end of the Esketamine treatment (n=30).Methods
The current study examines the role of the therapeutic group. It compares between the standard treatment protocol, with and without a therapeutic group. All participants completed three questionnaires, about their emotions, three times during the treatment (before the first session, after 4 sessions and after 8 sessions).ResultsWe will present first results as well as vignette to demonstrate.Conclusions

The expectation is to find a better patient experience and a better insight about the clinical changes following the Esketamine treatment, in the group which participates in the therapy groupDisclosureNo significant relationships.
Levothyroxine supplementation among individuals with Subclinical Hypothyroidism and Depression | a review
Authors: Ribeiro M. , Lourenço A. , Lemos M. , Duarte A. 
Published: September 2022

IntroductionDepression is known to be associated with changes in the hypothalamic-pituitary-thyroid axis and the brain is a major target organ for thyroid hormone. Overt hypothyroidism can cause symptoms compatible with depression. However, its relationship with subclinical hypothyroidism (SCH) is not well established.ObjectivesTo review the literature regarding the effect of levothyroxine therapy among patients with SCH and coexistent depression.MethodsWe conducted a MEDLINE search using depression, subclinical hypothyroidism and levothyroxine as keywords, selecting studies written in English.ResultsSCH is defined as an elevated thyroid stimulating hormone with normal peripheric hormone levels. The association between SCH and depression is controversial. Some studies indicate that SCH had the same propensity with overt hypothyroidism, while others report that major affective symptoms are not associated with SCH, but are likely due to independent psychiatric diagnoses, which are common in the general population and occur with similar frequency in patients with SCH. Individuals with SCH are recommended to initiate levothyroxine replacement therapy only when their TSH level is above 10 mIU/L or if symptoms are present. There is a lack of evidence supporting the use of levothyroxine therapy to improve mental health outcomes and the majority of meta-analysis do not show relief of affective symptoms after levothyroxine therapy, among individuals with SCH.ConclusionsRoutine screening for depressive symptoms among individuals with SCH is important to prevent morbidity. Nevertheless, there is no evidence enduring levothyroxine supplementation in these cases. Further studies, with larger sample sizes and longer follow-up periods are needed to enlighten the potential benefit of this therapy.DisclosureNo significant relationships.
Proposal of a therapeutic algorithm for the psychopharmacological management of treatment-resistant depression
Authors: Sanz Giancola A. , Molina Liétor M.D.C. , Cuevas Iñiguez I. , Alvarez Garcia C. , Blanco Prieto M. 
Published: September 2022

IntroductionThe lack of a standardised definition for the concept of TRD and an adequate criteria for therapeutic response make difficult the management of patients with MDD who do not achieve remission with one or more courses of treatment. All classifications suggested to define TRD are arbitrary, partially evidence-based, subordinated to the pharmacological findings of the time in which they are written and with serious inconsistencies, making it difficult to construct a universal and enduring diagnostic system.ObjectivesConsidering that the most important goal in treating a patient with Major Depressive Disorder (MDD) should be remission and return to previous functionality, the search for a standardised, evidence-based classification system will allow timely and effective interventions leading to the reduction of this devastating condition.MethodsBibliographic reviewResultsThe proposed therapeutic algorithm arises from the combination of several fundamental principles for the management of treatment-resistant depression: the different classification systems of the concept, as well as the concepts of response, relapse, recurrence and remission; the scientific evidence found in the current literature, routine clinical practice, knowledge of switching and augmentation strategies, the new pharmacological targets and neurobiological hypothesis discovered, without forgetting finally the different clinical profiles of depressive symptomatology and the specific indications of each antidepressant.ConclusionsResistant depression is difficult to treat successfully and is not a uniform entity. Recently there has been a move to characterise treatment-resistant depression as ‘difficult-to-treat’ depression on the basis that the former description implies that depression treatments are normally effective and that non-response is therefore somehow abnormal.DisclosureNo significant relationships.
Effectiveness of vortioxetine in real-world clinical practice: French cohort results from the global RELIEVE study
Authors: Polosan M. , Rabbani M. , Simonsen K. , Ren H. 
Published: September 2022

IntroductionMajor depressive disorder (MDD) affects around 10% of the French population annually and significantly impacts patient functioning. Efficacy of vortioxetine was demonstrated in randomised controlled trials, data on its real-world performance is needed.ObjectivesTo describe the effectiveness and safety of vortioxetine in real-world setting from patients enrolled from France in the global RELIEVE study.MethodsRELIEVE was a prospective, multi-national, observational study of outpatients initiating vortioxetine treatment for MDD at physician’s discretion. Data were collected at routine clinical visits. Here we present the outcomes of treatment of patients in France. The primary outcome was functioning measured by SDS. Secondary outcomes included depressive symptoms measured by PHQ-9, cognitive symptoms measured by PDQ-5 and DSST. Changes from baseline to month 6 were estimated with a linear mixed model of repeated measures approach.ResultsA total of 184 patients (mean age, 50.2 years, 65% female, 67.9% of patients had at least one comorbidity) were enrolled from France and included in the analysis. Mean(SD) SDS total score, PHQ-9, PDQ-5 scores at baseline were 21.1(5.4), 17.5(4.7) and 11.7(4.4), the scores(SE) decreased by 10.9(0.59), 9.3(0.48) and 6.1(0.37) from baseline to month 6. Mean(SD) DSST improved from 41.6(15.2) at baseline to 49.1(19.0) at month 6. Safety and tolerability profile of vortioxetine was in line with previous studies.ConclusionsSustained improvements in overall functioning, depressive symptoms, cognitive function were observed in patients treated with vortioxetine in a real-world setting, which provided further evidence of effectiveness and safety of vortioxetine in a broad MDD population in France.DisclosureM. Rabbani is an employee of Lundbeck France. K. Simonsen and H. Ren are employees of H. Lundbeck A/S.
Mental Health and Information Reporting Assistant: technological innovation including low- and middle-income countries - an update
Authors: Zimmermann R. 
Published: September 2022

Introduction
According to the World Health Organization, addressing the mental health care gap for adolescents, especially in low-resource contexts, is a priority. Evidence-based assessment is crucial for selecting treatment strategies and for quality management.ObjectivesTo develop a digital platform for evidence-based assessments and implement it in different low-resource settings.MethodsThe project operates according to the principles of digital development (https://digitalprinciples.org/), including designing with the user, user testing, understanding the ecosystem, resusing software and being open source, think about sustainability and addressing privacy and security.ResultsDifferent implementation contexts (in Tanzania, Kosovo and Chile) will be presented.The learned lessons will be presented to the audience.ConclusionsMHIRA is a promising tool that helps bridge the gap regarding adolescent mental health in low-resource settings. Challenges include the clinicans attitude towards evidence based assessment, sustainability of the project and integration with the existing information technology eco-system and regulations.DisclosureNo significant relationships.
Developing A Smartphone-Based Application for the Behavioral Cognitive Therapy of Panic Disorder
Authors: Esen E.C. , Baykan H. 
Published: September 2022

IntroductionEven though cognitive behavior therapy is proven to be an effective treatment for panic disorder, the scarcity of psychiatrists cause many patients not to get a sufficient therapy. E-mental health applications are being developed to address this shortage, especially after the COVID-19 pandemic. However, none of the e-mental health applications developed so far has offered a structured cognitive behavioral therapy.ObjectivesWe are developing a mobile application which will integrate with psychiatric interventions that aims to make cognitive behavioral therapy more accessible.MethodsOur algorithm consists of multiple choice questions and answers to determine the progression of the algorithm. The first three sessions consist of psycho-education of the application and the cognitive therapy model of panic mostly. During the psycho-education sessions, patients’ symptoms during panic attacks and their catastrophic thoughts will be questioned to be used in following sessions. After the panic log has been introduced in the third session, patients will enter the details of their panic attacks right after they experience it and this information will be investigated in the following sessions. Progress for the cognitive restructuring will be monitored as the sessions proceed. Later session will also include in-session symptom induction exercises.Results
We are still on the development phase of the mobile application. Hence we do not have any data to present at the moment.ConclusionsOur main purpose is to develop a mobile application which will integrate with structured cognitive behavioral therapy process, reduce the workload of the therapist and is easily accessible through the smart phones.DisclosureNo significant relationships.
What can we say about the impact of teleconsultations on preventing psychiatric inpatient treatment during COVID-19 pandemic?
Authors: Figueiredo I. , Cargaleiro I. , Nascimento M. 
Published: September 2022

IntroductionTelepsychiatry was proved effective and satisfactory in settings like the emergency department and mental health services, but its use is historically restricted. Although there are several studies about telepsychiatry pros and cons, more is needed to know about its effect on patient’s follow-up and its influence on inpatient treatment rates, specifically during COVID-19 pandemic.ObjectivesThe aim is to look for an eventual change on psychiatric inpatient admissions, during COVID-19 pandemic, when psychiatric patients are in follow-up through teleconsultation.MethodsWe compared the number of hospitalizations for 3 different 6 months periods of time: the 2nd semester of 2019 with no teleconsultations, March-August 2020 only with teleconsultations (except some few 1st consultations) and the 1st semester of 2021 with face-to-face and teleconsultations. A one-way repeated measures ANOVA was conducted on a 1050 patients sample.ResultsThe statists showed that the type of approach in consultations didn’t lead to statistically significant differences in hospitalizations (F test-statistic = 0.33086, p = 0.718345).ConclusionsThere is a plethora of advantages about telepsychiatry and it was already shown to be as effective as in-person contact. Some articles show an association of telepsychiatry with a decrease in hospitalization rates, but mostly display similar clinical outcomes. In this study, the authors found that the results follow the latter tendency, although we must consider the COVID-19 pandemic as a possible decompensation and worsening clinical factor. More studies on this matter are important to better understand the potential benefits (and risks) of this treatment setting.DisclosureNo significant relationships.
Attitudes towards body and perception of parental care and close relationships in anorexia nervosa (AN)
Authors: Karpenko P. , Pechnikova L. , Zhuykova E. , Sokolova E. , Ryzhov A. , Ioannisyants O. 
Published: September 2022

IntroductionThe links between body image disturbances and distorted relationships with parents were supposed since the early conceptualizations of AN by Hilde Bruch. The empirical studies however were concerned with perceptual aspects of body image and much less is known about how the attitudinal aspects and the body-related behaviors are affected.ObjectivesTo study the attitudinal and behavioral aspects of body image in adolescents with AN in relation to perceived parental care and the attachments to close people.MethodsThe Body Investment Scale (BSI), Parental Bonding Instrument (PBI) and Attachment Style Questionnaire (ASQ) were used. 53 girls with Anorexia Nervosa were compared to 63 controls (adjusted by age).Results
Girls with AN scored significantly higher on BIS Body attitude (p<.001) and Protection scales (p<.01), while displayed equal results on Body Care scale. They displayed lower Confidence in relationships (p<.01), higher Need for approval, Discomfort and preoccupation in close relationships (p<.05). No differences were found on PBI, excerpt for AN group perceiving less paternal control (p<.05). The correlation analysis, while showing a number of similar correlations within groups, suggests that in AN group positive Body image was more closely linked to perceived early care, especially from father (r=.6), in contrast with controls. In current relationships negative Body image for AN is stronger related to Discomfort and Need for approval (r>0.6), while Discomfort with Touch is less linked to problems in relationships than in controls.ConclusionsResults suggest the importance of studying the father’s mediating role in the formation of body attitudes in AN.DisclosureNo significant relationships.
Eating disorder and suicide attempt
Authors: Chaara A. , Laboudi F. , Ouanass A. 
Published: September 2022

IntroductionThe quantification of suicidal risk in specific populations is important for the adoption of prevention and risk reduction measures. This risk remains very high in patients with eating disorders compared to the general population.ObjectivesThe present study evaluates the prevalence of suicide among patients with eating disorders all seeking different suicidal risk factors in these patients.MethodsA retrospective study of medical records of all patients with eating disorders, diagnosed according to DSM 5 criteria, at Arrazi hospital of Salé for the past 14 years, by assessing the prevalence of suicide attempts and care.ResultsIn our work, all patients are female, 17 years old on average, 18 patients out of 20 have anorexia nervosa, 4 of them have had bouts of bulimia, and only one patient was admitted for management of bulimia nervosa alone. The mean age of onset was 15 years with addictive comorbidity in 5 patients.
Thirteen patients had comorbid depressive disorder, one patient was schizophrenic and six patients had borderline personality disorder.12 patients have made suicide attempts, planned especially in a depressive environment.ConclusionsPreventive management of suicidal risk must be taken in order to improve the prognosis in this category of patients.DisclosureNo significant relationships.
The evaluation of distorted body image in anorexia nervosa
Authors: Ciwoniuk N. , Wayda-Zalewska M. , Kucharska K. 
Published: September 2022

IntroductionA distorted body image appears to be a significant factor predisposing an individual to developing anorexia nervosa and its maintaining. Anorexia nervosa presents with the highest mortality rate among all mental disorders.ObjectivesThe aim of the research work was to assess the distorted body image in women diagnosed with anorexia nervosa, as well as to analyse the impact of the severity of the symptomatology of eating disorders, level of depression and anxiety on the distorted body image.Methods

A total of 105 people participated in the study. The clinical group consisted of 36 women diagnosed with anorexia nervosa, while the group of healthy women consisted of 69 participants. Patients completed several psychological and clinical measures such as: EAT-26, BSQ-34, BIDQ, BDD-YBOCS, CDRS, CESDR, and STAI.ResultsBetween group comparisons were performed using nonparametric the Mann-Whitney U test. Results revealed statistically significantly greater distorted body image perception in anorexia group. Women diagnosed with anorexia nervosa showed significantly higher levels both depression and anxiety compared to the healthy controls. Based on correlation analyses, it was shown that there are statistically significant relationships between the body image variable and eating disorders, depression, and anxiety (state and trait).ConclusionsTo deepen the problem of distorted body image, further research is required on etiopathogenesis and dynamics of body image in relation to body mass index and illness chronicity.DisclosureNo significant relationships.
Psychiatric Causes of Bariatric Surgery Exclusion: A Descriptive Study
Authors: Vilella Martín C. , García Vázquez P. , Barrera García Y. , Fernández Perea P. , Serrano García A. , Franch Pato C. , Gómez Martínez R. 
Published: September 2022

IntroductionThe psychopathological causes that advise against a bariatric surgical procedure include any state that puts at risk the modification of habits and beliefs regarding eating behavior, wich condition weight loss and health improvement.ObjectivesTo Study the psychiatric profile of patients rejected for bariatric surgery at the Complejo Hospitalario Asistencial de León (León, Spain).MethodsRetrospective observational study. All patients for whom bariatric surgery procedure has been contraindicated for psychopathological reasons are included. 145 patients were evaluated in the context of the protocol for bariatric surgery. The following diagnostic scales were used as support: Salamanca Questionnaire, Plutchik Impulsivity Scale, Attitudes towards change in patients with eating disorders (ACTA), Bulimia Investigatory Test Edinburgh e, and European Quality of Life-5 Dimensions.Results41 Patients were rejected for psychiatric reasons (28.28%). The most frequent diagnoses are impulse control disorder (39%), followed by eating disorder (27%). Other diagnoses found are: depressive disorder (10%), adjustment disorder (5%), personality disorders, intellectual disability and generalized anxiety disorder (3%) 78% of them are women.ConclusionsUncontrolled psychiatric pathology is a contraindication to bariatric surgery. Impulse control disorder and eating disorder are related to overweight and obesity, so a diagnosis and treatment are necessary prior planning surgical procedure. Psychopathological variables determine the success of bariatric surgery procedures and it is mandatory to consider them in the process.DisclosureNo significant relationships.