bluuebunny/crossref_metadata_2025_split huggingface dataset:
Major basic protein deposited at intra mucosal epithelium with probable eosinophilic chronic rhinosinusitis
Authors: Suzuki Satoshi , Kudo Naomi , Matsushita Daisuke , Hara Ryutaro , Miura Tomoya , Matsubara Atsushi 
Published: July 2022

Background
Eosinophilic chronic rhinosinusitis (ECRS) is diagnosed by Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) scoring system and histopathological eosinophil counts of dissected nasal polyps. Patients with low JESREC score and small number of tissue eosinophils are diagnosed with non-ECRS (NECRS). Due to the 2 parameters of this diagnostic system, chronic rhinosinusitis is to be divided to 4 groups and some patients fall into the 2 groups other than ECRS and NECRS: probable ECRS (pECRS) and probable non-ECRS (pNECRS). We attempted to clarify clinical and histopathological similarities and differences, especially concerning major basic protein (MBP), among those groups.

Methods
One hundred twenty-eight patients treated by endoscopic sinus surgery was included. Clinical characteristics were compared among each group, and immunohistological analysis for MBP was performed to 35 randomly selected patients. MBP deposition at intra mucosal epithelium was evaluated by semiquantificational approach.

Results
ECRS patients showed significantly higher comorbidity rate with allergic rhinitis (36 patients, 78.3%), asthma (36 patients, 78.3%) compared with other groups. Also, percentage of the patients complaining olfactory dysfunction (42 patients, 91.3%) was significantly higher (p < 0.001). Lund-Mackay score (mean, 14.5; 6-24) and recurrence rate (27 patients, 61.4%) was the highest in ECRS patients. Regarding pECRS, the number of patients with olfactory dysfunction (5 patients, 55.6%) was higher than pNECRS and NECRS groups. Also, comorbidity of asthma and percentage of blood eosinophils tended to be higher than those 2 groups. MBP score of pECRS group was significantly higher than NECRS (p < 0.05), despite of smaller tissue eosinophil counts.

Conclusion
pECRS might share some characteristics with ECRS although tissue eosinophil count was significantly smaller compared with ECRS. The results of this study have shown that MBP score in pECRS nasal polyps was significantly higher than NECRS patients and close to ECRS. That might suggest that eosinophils have existed in the nasal polyps of pPECRS patients at some point before surgery.
Tranexamic Acid Associated With Less Wound Complications in Ankle and Hindfoot Surgery
Authors: Moore Andrew D. , Smith Benjamin R. , O'Leary Ryan J. , Hoch Caroline P. , Gross Christopher E. , Scott Daniel J. 
Published: July 2022

Introduction:
The purpose of this study was to determine whether total ankle arthroplasty (TAA) and ankle/hindfoot fusion patients receiving tranexamic acid (TXA) exhibit fewer wound complications.

Methods:
A retrospective review was conducted of 212 patients (217 feet) undergoing TAA (n = 72), ankle (n = 36), tibiotalocalcaneal (n = 20), pantalar (n = 1), or hindfoot fusion (ie, subtalar = 47, double = 33, and triple = 8) between 2015 and 2020 by a fellowship-trained foot and ankle surgeon at an academic medical center. Demographics, medical history, complications, and union status were compared between TXA (n = 101) and non-TXA (n = 116) cohorts. The mean follow-up was 1.24 years (range, 0.25 to 4.68).

Results:
The TXA group had significantly less postoperative infections (5.9% versus 15.5%, P = 0.025). Within a subgroup analysis of ankle/hindfoot fusions, the TXA group exhibited significantly more Charcot neuroarthropathy (20.7% versus 5.7%, P = 0.006) and shorter follow-up duration (0.96 versus 1.30 years, P = 0.030); however, TXA was associated with shorter time to fusion (146 versus 202 days, P = 0.049) and fewer revision surgeries (8.6% versus 21.8%, P = 0.036). Subgroup analysis excluding feet with Charcot also demonstrated less postoperative infections (4.5% versus 14.4%, P = 0.020). Subgroup analysis of TAAs showed fewer cases of superficial infections (2.3% versus 27.6%, P = 0.002) and delayed wound healing (25.6% versus 48.3%, P = 0.047) in the TXA cohort.

Discussion:
TXA use in ankle/hindfoot surgery was correlated with a reduction in superficial infections and radiographic time to union. The use of TXA in TAA correlated with fewer superficial infections and cases of delayed wound healing. Thus, in addition to other areas of orthopaedics, TXA seems to be beneficial in hindfoot and ankle surgery.

Data availability and trial registration numbers:
All data were obtained from our institution's medical records. This study is not associated with a clinical trial.
Mortality and Conversion to Transfemoral Amputation After Transtibial Amputation in the Veterans Affairs Health System
Authors: Wong Liam H. , Woelber Erik , Madison Cecelia J. , Nguyen Khanh P. , Sangeorzan Bruce J. , Meeker James E. , Gundle Kenneth R. 
Published: July 2022

Introduction:
Transtibial below-knee amputation (BKA) is associated with considerable morbidity, particularly in the vasculopathic population. The purpose of this study was to determine the cumulative probability of undergoing transfemoral above-knee amputation (AKA) conversion within 5 years of BKA and associated risk factors while accounting for the competing risk of death.

Methods:
This is a retrospective, national database study with structured query of the Veterans Affairs (VA) database for patients who underwent BKA from 1999 to 2020, identified by Current Procedural Terminology codes. Above-knee amputation conversion was identified using Current Procedural Terminology codes in combination with natural language processing to match procedure laterality. After internally validating our patient identification method, risk factors were collected. Competing risk analysis estimated the cumulative incidence rate of AKA conversion and associated risk factors with death as a competing risk.

Results:
Our query yielded 19,875 patients (19,640 men, 98.8%) who underwent BKA with a median age of 66 years (interquartile range, 60 to 73). The median follow-up was 951 days (interquartile range, 275 to 2,026). The crude cumulative probabilities of AKA conversion and death at 5 years were 15.4% (95% confidence interval [CI], 14.9% to 16.0%) and 47.7% (95% CI, 46.9% to 48.4%), respectively. In the Fine and Gray subdistribution hazard model, peripheral vascular disease had the highest AKA conversion risk (hazard ratio [HR] 2.66; 95% CI, 2.22 to 3.20; P < 0.001). Other factors independently associated with AKA conversion included urgent operation (HR 1.32; 95% CI, 1.23 to 1.42), cerebrovascular disease (HR 1.19; 95% CI, 1.11 to 1.28), chronic obstructive pulmonary disease (HR 1.15; 95% CI, 1.07 to 1.24), and previous myocardial infarction (HR 1.10; 95% CI, 1.02 to 1.19) (All P < 0.02).

Discussion:
Within this predominantly male, VA population, BKA carries a high risk of conversion to AKA within 5 years, without reaching a steady risk of AKA conversion within 5 years. Peripheral vascular disease, chronic obstructive pulmonary disease, cerebrovascular disease, previous myocardial infarction, and urgent BKA increase the risk of AKA conversion.

Level of Evidence:
Level III
A Comparison of Operative Time and Intraoperative Blood Volume Loss Between Stemless and Short‐stem Anatomic Total Shoulder Arthroplasty: A Single Institution's Experience
Authors: Gruson Konrad I. , Lo Yungtai , Stallone Savino , Qawasmi Feras , Lee Sung , Shah Priyam 
Published: July 2022

Introduction:
There has been increasing interest in the use of stemless humeral implants for total shoulder arthroplasty when compared with both short-stem (SS) and standard-length implants. Although evidence for decreased surgical time and blood loss exists for stemless versus standard-length stems, far less literature exists comparing these clinical parameters for stemless versus SS implants.

Methods:
A retrospective review of consecutive anatomic total shoulder arthroplasty (aTSA) cases conducted by a single, fellowship-trained shoulder surgeon was undertaken from January 2016 through January 2022 with the exception of March 2020 through January 2021 secondary to the COVID-19 pandemic. Demographic patient and surgical data, including age, sex, body mass index, American Society of Anesthesiologists score, age-adjusted Charlson Comorbidity Index, prior ipsilateral shoulder arthroscopy, surgical time, use of a Hemovac drain and/or tranexamic acid, hospital length of stay (LOS), and both postoperative day #1 (POD 1) and discharge visual analog scores. The use of a stemless or SS implant was recorded. Intraoperative total blood volume loss (TBVL) was calculated, in addition to the need for either intraoperative or postoperative transfusions. Nonparametric analysis of covariance was used to examine effects of stemless versus SS aTSA on surgical time and intraoperative TBVL adjusted for demographic, clinical, and surgical variables.

Results:
There were 47 SS and 83 stemless anatomic implants included, of which 74 patients (57%) overall were women. The median surgical time for the stemless cohort was 111 minutes (IQR 96-130) versus 137 minutes (IQR 113-169) for the SS cohort (P < 0.00001). The median intraoperative TBVL for the stemless cohort was 298.3 mL (IQR 212.6-402.8) versus 359.7 mL (IQR 253.9-415.0) for the SS cohort (P = 0.05). After multivariable regression analysis, use of stemless humeral implants was independently associated with both decreased surgical time and intraoperative blood loss (P < 0.001 and P = 0.005, respectively). There was a shorter median hospital LOS in the stemless group (2 days [IQR 1-2] versus 2 days [IQR 2-3], P = 0.03). The visual analog score pain score at discharge was lower among the stemless cohort (0 [IQR 0-3] versus 4 [IQR 2-6], P < 0.00001). Increased surgical time was associated with intraoperative TBVL (r = 0.340, P < 0.0001).

Discussion:
Stemless aTSA is associated with a markedly decreased surgical time and intraoperative TBVL when compared with a SS aTSA. Furthermore, the use of a stemless implant results in a shorter hospital LOS and lower discharge pain scores.
De nieuwe Groepsvrijstelling verticalen: twee stappen voorwaarts, een stap terug
Authors: van der Heul Sjaak , Arnold Thomas 
Published: July 2022

De nieuwe Groepsvrijstelling verticalen: twee stappen voorwaarts, een stap terug
Op 1 juni 2022 zijn de herziene Groepsvrijstellingsverordening voor verticale overeenkomsten en herziene Richtsnoeren inzake verticale beperkingen in werking getreden. De herziene verordening en richtsnoeren actualiseren de voorwaarden waaronder verticale overeenkomsten profiteren van de veilige haven. In deze bijdrage bespreken wij de wijzigingen die de Europese wetgever invoert ten opzichte van het vorige regime en de mogelijke gevolgen daarvan voor ondernemingen.
Verschillen tussen mannen en vrouwen bij enquêtes voor marktafbakening en fusieanalyse
Authors: Damstra Lola , Rosenboom Nicole , Kuipers Max 
Published: July 2022

Verschillen tussen mannen en vrouwen bij enquêtes voor marktafbakening en fusieanalyse
Dit artikel kijkt er specifiek naar hoe er in de context van een marktafbakening of fusieanalyse rekening kan worden gehouden met de verschillen tussen mannen en vrouwen en welke gevolgen dat kan hebben op de uitkomst van de analyse als dit niet wordt gedaan.Er kunnen aanzienlijke verschillen zijn in het consumentengedrag per geslacht, en er zijn verschillende mechanismen waardoor deze verschillen een effect kunnen hebben op de marktdefinitie of tot verschillende fusie-effecten kunnen leiden.
Apple/ACM
Authors: Braeken Bas , van den Berg Demi 
Published: July 2022

Apple/ACM
Op 24 december 2021 liet de voorzieningenrechter de door de ACM opgelegde last onder dwangsom aan Apple grotendeels in stand. Door datingappaanbieders te verplichten gebruik te maken van het betalingssysteem van Apple, maakt zij misbruik van haar machtspositie. Het relatief onderontwikkelde concept van onbillijke voorwaarden staat daarbij centraal. Ondanks een aantal juridische nederlagen pakt de ACM (uitbuitings)misbruikzaken de laatste tijd weer op. De App Store-voorwaarden blijven zelf ook nog onderwerp van onderzoek in andere landen.
Het emotionele regime van herstelrecht
Authors: van Stokkom Bas 
Published: July 2022

The emotional regime of restorative justice – Demanding display rules and arduous emotion work
In this study the author points out that ritual theories of restorative justice – which revolve around emotional bonding – fail to explain the rather low emotional temperature of many (youth) conferences. Emotion management theory may offer a more adequate explanation, thereby suggesting that participants’ reservations and discomfort are related to demanding display rules (enact a sincere and authentic role; enact cooperativeness; etc.). It is argued that display rules form an integral part of a relatively compelling ‘emotional regime’, a specific set of affective behavioural norms which define the ‘manners’ during the meeting. In this regime there is considerable social pressure to conform to norms and standards how to express emotions, which contradicts the restorative justice rhetoric of voluntary dialogue, free of coercion.
Wroclaw: stad van honderden bruggen als Restorative City
Authors: Matczak Anna 
Published: July 2022

Wrocław: city of hundred bridges as restorative city
The article describes what a restorative city is by looking at research, experiences in different countries and by describing the developments in Restorative City Wrocław. A restorative city is a city that recognises its urban environment as a network of relations in which – in the case of conflict – citizens, institutions and organisations choose a restorative approach to finding a solution in the first place. This necessitates proactive responses to conflict resolution, which go beyond criminal justice and crime prevention strategies that are still predominantly of a reactive nature. The concept of the restorative justice city builds a ‘criminology of trust’, for which crime is not a risk to be managed and controlled but a harm to be addressed by penal policies based on respect, solidarity, inclusion and active participation The restorative city concept, as also seen in Wrocław, is gaining momentum and while it is becoming an appealing policy transfer in an increasingly globalized world.
THE ROLE OF PHYSICAL MEDICINE AND REHABILITATION IN LONG COVID-19 MANAGEMENT
Authors: Koçyiğit Burhan Fatih 
Published: July 2022

COVID-19 is an infectious disease that can have a multi-system involvement, most notably, the respiratory tract. After acute infection, a considerable proportion of patients suffer from persistent symptoms and signs, defined as long COVID-19. Depending on the affected systems and organs, patients can experience various clinic pictures. Rehabilitation approaches serve a crucial role in providing functional recovery and improving quality of life for COVID-19 survivors. As a result of the wideness of the clinical spectrum of the long COVID-19, rehabilitation practices differ according to the affected systems. Therefore, the formation of multidisciplinary rehabilitation teams is an inevitable necessity. The establishment of specific centers for long COVID-19 rehabilitation will be beneficial. If it is not possible, existing rehabilitation centers should be strengthened for this purpose. Since the pulmonary system and respiratory tract are the most affected structures, one of the main issues to be considered in long COVID-19 cases is cardiopulmonary rehabilitation. Patients experience musculoskeletal disorders such as atrophy, sarcopenia, poor physical performance and contracture due to long-term hospitalization, intensive care treatment, quarantine practices and immobilization. Rehabilitation practices also focus on these disorders. All rehabilitation practices in long COVID-19 patients should start with low intensity, and parameters such as intensity and frequency should be increased as the patient's tolerance improves. In high-risk cases, parameters including oxygen saturation, blood pressure, and heart rhythm should be monitored. Health-care authorities should prioritize the rehabilitation of the long COVID-19 syndrome and invest in this area. Authorities, physicians and patients should collaborate to facilitate long COVID-19 rehabilitation and to establish a self-contained system.
Information Managers as Change Agents in achieving Sustainable Development in the 21st Century
Authors: Bakare, Oluwabunmi.D.  , Okuonghae Nosakhare 
Published: July 2022

The purpose of this paper is to examine the role of information managers and libraries in accomplishing Nigeria's sustainable development goals in the 21st Century. The paper explored the notion of sustainable development, examines the 17 Sustainable Development Goals (SDGs) including their respective targets. It identifies and discusses the role of libraries and information managers (librarians) in achieving SDGs, as well as the philosophy of information theory of communication as proposed by Claude Shannon (1948). Libraries all over the world offer a variety of products and services that support the accomplishment of all 17 SDGs. Libraries are secure, friendly spaces at the heart of communities, fostering reading and providing free access to information. Libraries are vital instruments in society, and they play a critical role in accomplishing long-term development goals. Citizens must be well informed if Nigeria's sustainable development goals are to be met and sustained. This can be accomplished by selecting, processing, organizing, and disseminating information based on the parameter of development as indicated in the Sustainable Development Goals (SDGs), and organizing training programs or forums where issues such education, environmental, climate change, gender inequality and health issues can be discussed, and so on.
Time to DTR: fan paratextualization about Game of Thrones last season
Authors: Moura Bruno Melo , De Souza-Leão André Luiz Maranhão 
Published: July 2022

Purpose: Media products meaning lies on the interpretation of its content. As productive consumers, fans reframe them. In the process, they produce new texts on these products, known as paratexts. The research aims to understand how fan’s paratexts (re)produces discourses to re-signify media products’ (para)texts. For such, we look at fan paratextualization of Game of Thrones (GoT), an economic and cultural phenomenon with huge repercussions on social media.
Design/methodology/approach: Through a Foucauldian Archeology, we collected and analyzed comments posted by GoT fans on promotional videos published on the TV series' official YouTube channel.
Findings: The fans' paratextual production presents different positions on the consumed cultural product: a public tribute highlighting its cultural legacy that is based on feelings of nostalgia and frustration with the conclusion of its plot. We conclude that these paratexts worked as a reckoning for the TV series’ fans. Broadly, it is possible to interpret paratexts as marketing content that allow fans to act as prosumers of media products, the entertainment industry, and fans' culture.
Originality/value: The study presents how the fans’ productive consumption is materialized through the paratext (re)production that both establish the resonance of media objects in the culture of fans and lead them to assume the role of co-authors of the texts they consume. This role reinforces how fans should be understood as consumers who can act freely in relation to marketing actions. Moreover, it implies that paratexts can be produced to stimulate the discursive production that works as prosumer performance of fans.
Lo spartano Antalcida, xenos e philos di Artaserse?
Authors: Bianco Elisabetta 
Published: July 2022

The article illustrates the career of the Spartan Antalcidas, who between 392 and 367 BC ca. carried out an intense military activity and led several diplomatic missions at the court of the King of Persia. Special attention is given to the analysis of Antalcidas’ diplomatic masterpiece, the common peace of 387/6, which took its name from him. His friendship with the satrap Ariobarzanes, as well as the favor shown to him by king Artaxerxes II (with whom, however, never existed a real bond of xenia), place him among the most prominent Spartan characters in international relations of the first half of the 4th century BC.
Tra Macedoni e Persiani: Ermia di Atarneo
Authors: Gallo Luigi 
Published: July 2022

Starting from a passage of Demosthenes’ Fourth Philippic, the essay examines the career of Hermias of Atarneus, in particular the controversial issue of his relationship with Philip II of Macedonia. In this regard, an attempt is made to reject the claim that the arrival of Aristotle at Hermias was desired by Philip to secure a bridgehead for the expedition to Asia, whereas there is no reason to believe that this expedition had already been planned in the first half of the Forties. In fact, it is reasonable to think that the relationship with Hermias, which probably began after Aristotle’s arrival at the Macedonian court in 343, was of no particular importance to Philip.
Le relazioni internazionali degli esuli politici durante l’egemonia spartana: l’esempio degli esuli rodii
Authors: Loddo Rita Laura 
Published: July 2022

The aim of this paper is to consider the ways in which political exiles acted in their relations with other states during the first phase of Spartan hegemony and up to the stipulation of the Peace of Antalcidas. It analyses as a case study the actions of those Rhodians who became exiles during the revolts that shook the island in the first decade of the 4th century BC. After a brief introduction, the paper focuses on the contexts that led to the proliferation of exiles in the period under consideration dwelling on the special relationship of mutual support between the Spartan king Agesilaus and the exiles. Then it analyses the case of the Rhodian exiles as an example of the general activism of the political exiles. They presented themselves as groups opposed to the governments in power or to precise policies that these governments supported and resorted to the traditional means of political struggle. By so doing, they broadened the area of political action outside the polis, politicising their exile with strategies that recall, at least embryonically, forms of modern political transnationalism.
Il problema dell’autonomia dei confederati nel contesto di un’alleanza egemonica. Tracce di un dibattito nella demegoria Sul trattato con Alessandro ([Dem.] XVII)
Authors: Poddighe Elisabetta 
Published: July 2022

This article offers a reinterpretation of the pseudo-Demosthenic demegory On the Agreements with Alexander that reassesses the legal basis of the arguments offered by the speaker as regards the legal nature of the pacts and Alexander’s violations on this point. According to this interpretation, the Athenian speaker specifically focuses on the violations committed by Alexander as hegemon with respect to the commitments assumed by the Athenians in the symmachia as participants in the koine eirene. The most recent research acquisitions on the question of the attribution of the demegory and the context of its recitation lead to a reconsideration of the legal arguments offered by the speaker about the relationship between the koine eirene and the symmachia. In line with these acquisitions, the argument here proposed is that at the heart of the oration was the claim of the Athenians’ right not to follow unconditionally (ἀκολουθεῖν) the strategic direction taken by the hegemon, immediately after his passage through Asia, and to exit, if necessary, the koine eirene.