bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ginseng ameliorates pulmonary toxicity induced by silicon dioxide nanoparticles in rats
Authors: El-Sayed Raghda A. , El-Demerdash Fatma M. , El-Magd Mohammed A. 
Published: March 2022

Objective:
To investigate the protective and therapeutic role of ginseng against silicon dioxide nanoparticles (SiO2NPs)-induced toxicity in the lungs.

Methods:
Sixty male rats were divided into five groups (n = 12/ group); group 1 was used as a control, group 2 received ginseng, group 3 was treated with SiO2NPs, and group 4 was pretreated with ginseng one week before SiO2NPs, while group 5 was given SiO2NPs one week before supplementation with ginseng. Animals were treated with both ginseng and SiO2NPs orally for five weeks. Real-time PCR was used to measure gene expression. Besides, DNA damage and cell cycle changes were determined by comet assay and flow cytometry, respectively. Histological study was also done to assess the effect of ginseng on SiO2NPs-induced toxicity.

Results:
SiO2NPs increased lipid peroxidation and decreased the activities of antioxidant enzymes. SiO2NPs induced apoptosis in lung tissues as revealed by upregulation of Bax and caspase 3 and downregulation of Bcl-2 as well as the induction of DNA damage. SiO2NPs also caused inflammation as indicated by upregulation of the inflammation-related genes [interleukin 1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), nuclear factor kappa B (NF-κB), cyclooxygenase 2 (COX2), and transforming growth factor-beta 1 (TGFβ1)] as well as cell cycle arrest in the G0/G1 phase of lung cells. Moreover, histopathological examination proved the biochemical and molecular perturbations that occurred due to SiO2NPs toxicity. However, ginseng alleviated SiO2NPs-induced toxicity in rat lung.

Conclusions:
Ginseng has a potent preventive and therapeutic effect and could be used in the treatment of SiO2NPs-induced pulmonary toxicity.
Gracilaria fisheri oligosaccharides ameliorate inflammation and colonic epithelial barrier dysfunction in mice with acetic acid-induced colitis
Authors: Siringoringo Brenda , Huipao Nawiya , Tipbunjong Chittipong , Nopparat Jongdee , Wichienchot Santad , Hutapea Albert M. , Khuituan Pissared 
Published: March 2022

Objective:
To investigate the effect of Gracilaria fisheri oligosaccharides (GFO) on inflammation and colonic epithelial barrier dysfunction in colitis mice.

Methods:
The animals were treated by oral gavage with distilled water, 1 000 mg/kg inulin, 100, 500, or 1 000 mg/kg GFO for 14 d, or treated with 50 mg/kg mesalamine for 5 d after colitis induction (on day 10). Histopathology, inflammatory cytokines, colonic permeability, and tight junction proteins were investigated by hematoxylin and eosin staining, immunohistochemical staining, Ussing chamber technique, and Western blotting assays, respectively.

Results:
GFO ameliorated histological damage in colitis mice when compared to untreated colitis mice. Treatments with 100, 500, and 1 000 mg/kg GFO reduced TNF-α expression, while IL-1β was significantly reduced in colitis mice treated with 500 and 1 000 mg/kg. Compared to untreated colitis mice, GFO increased transepithelial electrical resistance, reduced fluorescein isothiocyanate-dextran paracellular flux, and modulated tight junction proteins (occludin and claudin 2) in colitis mice.

Conclusions:
GFO has anti-inflammatory activity and could modulate colonic epithelial barrier dysfunction in acetic acid-induced colitis mice. Furthermore, GFO could modulate the expression of tight junction proteins that play important roles in colonic barrier function.
Relaxant Effect of Bioactive Component Compatibility of San-ao Decoction on In vitro Guinea Pig Airway Smooth Muscle
Authors: Song Wen-Jie , Fu Yan-Ling , Ni Sheng-Lou , Fan Jia-Jia , Du Qian , Zheng Hao 
Published: March 2022

Background:
Component compatibility is important to the modernization of traditional Chinese medicine. Studies have shown that San-ao decoction (SAD) can treat respiratory diseases by relaxing airway smooth muscle (ASM) and reducing airway hyper-responsiveness. However, whether its bioactive components and compatibility also present with similar relaxant effects remains unknown. This study aims to explore the potential relaxant property, dose-response relationship, and underlying mechanisms of the bioactive component compatibility in SAD.

Methods:
Network pharmacology was primarily used to identify the bioactive components of SAD and uncover its underlying mechanisms. ASM tension force measuring technique was utilized to verify the relaxant and dose-response effects on in vitro guinea pig ASM.

Results:
We postulated pseudoephedrine hydrochloride (PH), amygdalin (AM), and diammonium glycyrrhizate (DG) to be the bioactive components of SAD, which could effectively relax ASM in a dose-dependent manner on both acetylcholine-induced and spontaneous contraction. Both PH and AM could lead to DG dose–response curve shift. The regression equation of these three bioactive components was Y = −2.048 × X1 + 0.411 × X2 + 14.052 × X3 (X1, X2, X3 representing PH, AM, and DG, respectively). The underlying mechanisms of these components might be associated with the regulation of smooth muscle contraction.

Conclusions:
PH, AM, and DG are the bioactive components of SAD, which can relax ASM in a dose–response manner and exert a synergistic effect. Clinically, compatibility of these three bioactive components may serve as a new complementary and alternative treatment for respiratory diseases.
Molecular Evaluation of Human Parvovirus B19 Infection and Associated Risk Factors among Pregnant Women in Bushehr Province, Southern Iran
Authors: Taherkhani Reza , Farshadpour Fatemeh , Norozi Masomeh 
Published: March 2022

ABSTRACT.
Given the importance of human parvovirus B19 infection during pregnancy and the potential risks to the fetus, this study was designed to determine the prevalence, genotypic pattern, and risk factors of parvovirus B19 infection among a population-based sample of pregnant women in Bushehr Province, southern Iran. A total of 824 pregnant women were enrolled in this study. Serum samples were screened for the detection of anti-parvovirus B19 IgM and IgG by ELISA. The molecular evaluation was performed by nested polymerase chain reaction, targeting the non-structural protein 1–viral protein 1 unique region of the genome, and sequencing. Of 824 pregnant women, 330 (40.1%) were positive for anti-parvovirus B19 IgG and 50 women (6.1%) had anti-parvovirus B19 IgM. A greater rate of anti-parvovirus B19 IgG seroprevalence was observed in women older than 39 years, in Afghan immigrants, and in those women with more parities. Anti-parvovirus B19 IgM seroprevalence decreased with increasing gestational age and was significantly greater among women in the first trimester of pregnancy and among residents of the city of Borazjan. Moreover, 0.73% of the pregnant women had parvovirus B19 viremia with genotype 1 and subtype 1a. Parvovirus B19 DNA was detected in the samples collected in late autumn and winter, which is a rainy season associated with temperate climes in southern Iran. According to the results of this study, approximately 60% of pregnant women in this region are serologically negative and susceptible to parvovirus B19 infection. Therefore, assessment for maternal parvovirus B19 infection is important and should be considered as part of the fetal–maternal health policy in Iran.
Case Report: Calcified Cerebral Toxoplasmosis Associated with Perilesional Edema in People Living with HIV/AIDS: Case Series of a Presentation Mimicking Neurocysticercosis
Authors: Vidal José E. , Rivero René L. M. , dos Santos Sigrid de Sousa , Guedes Bruno F. , Gomes Hélio R. , Penalva de Oliveira Augusto C. , Garcia Hector H. 
Published: March 2022

ABSTRACT.
Perilesional edema, associated or not with neurological manifestations, is a well-characterized finding in cases of calcified neurocysticercosis. There are no previous reports of HIV-related calcified toxoplasmosis that mimics this presentation of neurocysticercosis. We report on five patients, four of them with new-onset neurological manifestations, who showed brain calcifications associated with perilesional edema. All cases had a history of HIV-related toxoplasmosis and current virological and immunological control of HIV infection. Similar to neurocysticercosis, brain calcified toxoplasmosis may cause perilesional edema and symptoms in people living with HIV/AIDS.
Genetic assessment of Mangifera indica Linn. (Mango) from selected locations in Oyo State, Nigeria
Authors: Olawuyi Joseph Odunayo , Ayodele Abiodun Emmanuel , Ezekiel Precious Chiwendu , Ajayi Isaac Iseoluwa 
Published: March 2022

This study characterized five (5) varieties of mango comprising 15 accessions collected from Ogbomosho, Saki, Ibadan and other locations in Oyo State. The field experiment was laid out in a Complete Randomized Design (CRD) with three replicates. Morphological characters were assessed on the stem, leaf and fruit. Also, Molecular studies (DNA amplification and sequencing) were carried out on 15 accessions of mango. The edited sequences were blasted in the National Center of Biotechnology Information (NCBI) data website. The Results showed variability in morphological characters of Mango. Ogbomosho Acc-2 performed best for leaf width (4.53cm) and lamina length (16.25cm) while Isehin Acc-1 had the highest number of leaves per seedling (7.76cm), leaf length (17.06cm), leaf area (38.84cm), petiole length (2.27cm), plant height (24.07cm) respectively. The Number of leaves had positive correlation with Leaf length (r=0.53), Leaf Area (r=0.59), Internodal Length (r= 0.55) and strong positive correlation with plant height (r=0.73) at p≤0.05. The success rate of amplified DNA products and sequencing was 77.78%. The query coverage of 99% and 100% confirmed positive amplification and sequencing of rbcL gene in the mango varieties. The sequences blasted in the NCBI data website were identified to be similar to accession KX871231.1. Sequences of rbcL marker showed genetic differences among samples; Grafe and OGBM Acc -1. Genetic distance between varieties from the same location was most often lower with Grafe mango being the most distant variety with genetic distance of 0.114-0.117. There were morphological and molecular variations in mango varieties and accessions. Isehin Acc-1, Saki Acc-1 and OGBM Acc-6 accessions had better growth performance
INTERAKSI SOSIAL KKM 46 PADA KEGIATAN KHITAN MASSAL DI DESA BANJARSARI KECAMATAN WARUNG GUNUNG KABUPATEN LEBAK TAHUN 2017
Authors: Fatari  , Asnawi  , Ahmad Munawir  , Surachman  , Gatot Hartoko  , Ardi Hidayat  , Hadi Kurniawanto  
Published: March 2022

Khitan atau sunatan sudah sangat familier dan biasa kita dengar. Dibeberapa tempat, acara khitanan anak anak bahkan dijadikan acara hajatan. Namun kegiatan yang dilakukan oleh kelompok 46 merupakan kegiatan pengabdian berupa interaksi social masyarakat. Tujuan dari penulisan ini untuk penyampaian informasi tentang kegiatan Kuliah Kerja Mahasiswa (KKM) Kelompok 46 di desa Banjarsari kecamatan Warung Gunung kabupaten Lebak, dari beberapa program kegiatan, KKM Kelompok 46 melaksanakan program pokok yaitu kegiatan Khitan Massal yang meliputi (1) partisipasi masyarakat dalam kegiatan dan langkah evaluasi terhadap pelaksanaan program dan (2) capaian program kerja dan dampak kegiatan bagi masyarakat khususnya dampak manfaat bagi masyarakat desa Banjarsari. Dalam pelaksanaan Kuliah Kerja Mahasiswa (KKM) STIE Bina Bangsa tahun 2017 oleh kelompok 46 menggunakan metode Participatory Rural Appraisal (PRA) dan metode pendekatan social kemasyarakatan. Pelaksanaan kegiatan Khitan Massal ini, diikuti oleh 10 (sepuluh) anak dari keluarga yang kurang mampu perwakilan setiap RT, yang berada di desa Banjarsari, dan berjalan lancar dari awal sampai akhir pelaksanaannya
PELATIHAN PEMBUATAN HANDSANITIZER ALAMI DENGAN EKSTRAK DAUN SIRIH DAN JERUK NIPIS UNTUK MENCEGAH PENYEBARAN COVID-19 DI DESA CUPAT PARITTIGA
Authors: Ardiansah Feri , Silawati  , Yesi  , Yuhani  , Fatayah Nur Isnani  
Published: March 2022

Beberapa cara untuk mencegah penyebaran covid-19 yaitu dengan menerapkan 3 M (mencuci tangan, menjaga jarak, dan menggunakan masker). Semakin bertambahnya kesibukan masyarakat dan menginginkan cara yang praktis dan efisen waktu dalam mencuci tangan, sehingga memunculkan inovasi untuk membuat cairan antiseptik berupa handsanitizer alami. Zat antiseptik yang terdapat didalam handsanitizer memiliki presentase alkohol 60-95%. Terdapat penelitian mengungkapkan bahwa daun sirih dengan kandungan ekstrak lebih dari 15% setara dengan kandungan alkohol dan etanol. Daun sirih mengandung berbagai macam kandungan seperti tanin, polifenol serta steroid. Sedangkan jeruk nipis memiliki kandungan kalsium, fosfor, zat besi, vitamin A, vitamin B1, karbohidrat, kalsium, energi dan vitamin C. Kedua bahan ini mengandung zat anti bakteri. Di desa Cupat tidak semua warga membudidayakan tanaman sirih dan jeruk nipis yang dapat digunakan untuk membuat handsanitizer alami. Handsanitizer alami ini dibuat tanpa campuran alkohol dan memanfaatkan daun sirih dan jeruk nipis yang ada di desa Cupat. Kegiatan ini adalah rangkuman dari inovasi dan bentuk pelatihan untuk mengajak masyarakat di desa Cupat memahami cara membuat handsanitizer alami ekstrak daun sirih merah dan jeruk nipis.
SOSIALISASI PENGGUNAAN AKUN MARKETPLACE BAGI USAHA KECIL DI CEMANDI SERTA PEMASANGAN PAPAN NAMA JALAN DI SEPANJANG, SIDOARJO, JAWA TIMUR
Authors: Stephanie Astrid Ayu  , Martina Ningtyas  
Published: March 2022

Program Pengabdian Masyarakat merupakan salah satu program kerja mahasiswa sebagai sarana pembelajaran dalam mengimplementasikan keterampilan untuk hidup bermasyarakat. Program kerja Pengabdian Masyarakat merupakan program wajib yang diselenggarakan oleh Universitas. Melalui program kerja Pengabdian Masyarakat, diharapkan mahasiswa dapat mengelola dan bekerja sama dengan semua unit terkait dalam upaya mewujudkan program kerja yang bermanfaat bagi masyarakat di tempat terselenggaranya program Pengabdian Masyarakat. Kondisi pandemic Covid-19 berdampak pada perubahan sistem dalam pelaksanaan program pengabdian masyarakat. Program kerja kelompok 7 UKDC dilaksanakan di 2 lokasi. Lokasi ditentukan dengan berdasarkan pada jarak lokasi yang tidak terlalu jauh dari tempat tinggal anggota kelompok Pengabdian Masyarakat. Lokasi Pengabdian Masyarakat Kelompok 7 berada di lingkungan Perumahan Griya Kartika Cemandi Kecamatan Sedati dan di Gang Cendrawasih RT 09 RW 06 Sepanjang, Kecamatan Taman, Sidoarjo.Program kerja pengabdian masyarakat ini bertujuan untuk membantu warga Griya Kartika dalam memasarkan dan mengelola usaha warga dalam bidang kuliner dengan memanfaatkan akun marketplace yang saat ini menjadi trend dalam dunia perkulineran. Program kerja di lokasi yang kedua, yaitu di Gang Cendrawasih RT 09 RW 06 Sepanjang, Kecamatan Taman, Sidoarjo adalah membantu warga dalam pembuatan papan nama jalan serta papan nomor rumah dalam rangka upaya mewujudkan manajemen tata kelola lingkungan tinggal warga. Program pengabdian masyarakat ini dilakukan dalam 3 tahapan yaitu tahapan awal, tahapan proses dan tahapan akhir. Tahapan awal dilakukan dengan melakukan kunjungan ke rumah warga RT 22 RW 05 Griya Kartika dan RT 09 RW 06 Sepanjang. Untuk tahapan proses dilaksanakan mulai dari pendataan warga di Griya Kartika untuk pembuatan akun marketplace serta pendataan rumah warga di RT 09 RW 06 Sepanjang terutama rumah warga yang belum memiliki nomor rumah. Selanjutnya proses pelaksaanaan pembuatan akun marketplace dan pembuatan serta pemasangan papan nama jalan dan nomor rumah di RT 09 RW 06 Sepanjang
Penerapan E-Commerce Pada Kelompok Pkk Di Kelurahan Drangong– Kecamatan Taktakan Kota Serang
Authors: Nuryanto Uly Wildan , Alayubi Shalahudin 
Published: March 2022

Penggunaan E-commerce dalam teknologi informasi semakin meningkat. Salah satu e- commerce yang sering digunakan akhir-akhir ini adalah marketplace. Dari sekian banyak yang marketplace yang tersedia, shopee adalah marketplace yang sering digunakan pelanggan, termasuk ibu-ibu PKK (Pemberdayaan dan Kesejahteraan Keluarga). Selama ini ibu-ibu PKK hanya berperan sebagai pelanggan tanpa menyadari potensi keuntungan finansial yang dapat diraih. Maka dari itu kami menyelenggarakan kegiatan abdimas dengan bentuk pembelajaran dan pemberian pelatihan berniaga menggunakan marketplace shopee. Kegiatan ini secara khusus bertujuan untuk membekali ibu-ibu PKK di Kelurahan Drangong dalam memaksimalkan marketplace shopee agar dapat berperan aktif dalam kegiatan perniagaan yang menghasilkan keuntungan finansial. Memaksimalkan market place shopee dapat meningkatkan penjualan dan meminimalisir pengeluaran karena tidak memerlukan toko fisik, biaya promosi atau biaya untuk membayar karyawan. Apalagi jika penjualannya masih dalam skala kecil, khususnya ibu-ibu PKK yang dapat melakukan penjualan tanpa harus meninggalkan kegiatan mereka sehari- hari sebagai ibu rumah tangga
PELATIHAN PEMBUKUAN AKUNTANSI SECARA SEDERHANA DAN DIGITAL BAGI KELOMPOK UP2K-PKK DESA SEMBAWA KECAMATAN JALAKSANA
Authors: Suhendar Dadang , Purnama Dendi , Nurhayati Neni 
Published: March 2022

The purpose of this community service activity is to increase knowledge and skills to the UP2K-PKK group of Sembawa village in carrying out simple and digital accounting bookkeeping. Metode the implementation of the activities used in this devotion using training methods. The number of participants who attended the devotional activities as many as 20 members of the UP2K-PKK group Sembawa Village. From the results of devotional activities that have been carried out that the participants enthusiastically participated in simple and digital accounting bookkeeping training. In theory, some participants understand the material that has been delivered by the speaker. But at the time of practice they are able to understand and practice simple accounting bookkeeping, grouping accounts, identifying and summing the balances of accounts in assets and assets. At the time of the practice of compiling income statements and financial statements, only a portion of participants were able to practice. In addition, during the practice of recording transactions into SME accounting applications some participants have difficulty in identifying and grouping the accounts used in each transaction. But after being given an understanding and accompanied by participants can record into SME accounting applications
Modelling spatiality’s, habitus, and capabilities in the Covid-19 era
Authors: García Lirios Cruz , Carreon-Guillen Javier , Sanchez-Sanchez Arturo , Martinez-Muñoz Bernardino 
Published: March 2022

Complexity has often followed two paths: the measurement of processes that are considered fractal, chaotic, dissipative or emergent, or the theorization of such processes. The objective of the present work is the elaboration of a model for its contrast in a second phase of the project. In this sense, a documentary work was carried out with a review of sources indexed to national repositories, using the Delphi technique for content analysis and model specification. The limits of the search, selection and processing of information are recognized, and it is recommended to extend the investigation to international repositories, as well as the use of a more sophisticated technique.
La lucha de los profesores por la disciplina escolar: una mirada desde la histórica
Authors: Barbosa María Ana Valle , Villavicencio María Elena Flores , López María Guadalupe Vega , De la Torre Armando Muñoz 
Published: March 2022

Objetivo: Describir la importancia de la disciplina escolar en la aulas, asimismo, a la problemática que se enfrentan los profesores para implementarla. Históricamente la disciplina en las escuelas se lograba mediante castigos, y Guadalajara, México, no fue la excepción. En la reglamentación de la Escuela de Artes, Oficios y Primeras Letras de Guadalajara los castigos han dependían de la observación del educador. Este fenómeno no es una problemática reciente, desde la revolución industrial se vigilaron los derechos de los niños y niñas, de acuerdo con las condiciones de abuso y explotación laboral que enfrentaban en dicho momento histórico. Hoy son temas de interés para los derechos humanos y la Salud Pública. En la actualidad, tanto el gobierno como la sociedad civil se han preocupado por la socialización escolar poniendo en práctica programas de intervención y prevención para impedir actos de insubordinación escolar, al mismo tiempo, sin dejar de lado los derechos de alumnos y profesores, considerarse de manera conjunta para conseguir la armonía necesaria del buen funcionamiento de las instituciones educativas, dicho de otra manera, que haya paciencia para admitir otras opiniones de las personas con respeto a su dignidad.
Prevalencia de depresión y factores asociados, en estudiantes de Medicina, Cuenca - Ecuador, 2019
Authors: Sarango Cinthia Gabriela Romero , Palacios Michell Susan Saavedra , Córdova Tania Diciana Arévalo , Jaen Jhon Jairo Molina , Cárdenas Verónica Tatiana Narea 
Published: March 2022

Introducción: La depresión contribuye significativamente a la carga mundial de morbilidad y afecta a personas de todos los países del mundo con una prevalencia global de episodios depresivos del 3,2%. Objetivo: Determinar la prevalencia y los factores asociados a la depresión en estudiantes de la carrera de medicina de las Universidades de la ciudad de Cuenca – Azuay - Ecuador. Metodología: Estudio multicéntrico, cuantitativo, descriptivo, transversal, no experimental. La población estuvo constituida por los estudiantes de la carrera de medicina de la Universidad de Cuenca, Universidad Católica de Cuenca, Universidad del Azuay, de la ciudad de Cuenca, Provincia del Azuay - Ecuador. Para la asociación de la depresión y los factores de riesgo, se usó el Odds Ratio. Resultados: La población de estudio tuvo una media de 21 años DE ± 2 años, con prevalencia del sexo femenino con 114 estudiantes de 272. La prevalencia de depresión fue de 61.1%. Los factores de riesgo tuvieron asociación con la depresión fueron: el sexo femenino, OR: 2,35 (IC 95%: 1,35 – 4.86 p= 0,001); el estar satisfecho con la carrera de medicina OR: 1,53 (IC 95%: 1,4 – 1,67 p= 0,01); el recibir apoyo social OR: 1.52 (IC 95%: 1,39 – 1,66 p= 0,03); con significancia estadística. Conclusión: Existe alta prevalencia de depresión entre los estudiantes de las Universidades de la ciudad de Cuenca – Ecuador, principalmente en el sexo femenino. Los factores que tuvieron asociación con la depresión fueron: el sexo femenino, estar satisfecho con la carrera y recibir apoyo social.