bluuebunny/crossref_metadata_2025_split huggingface dataset:
Importance of a multi-tiered treatment approach for intellectually and developmentally disabled patients with hidradenitis suppurativa
Authors: Nosrati Avigdor , Torpey McCall E. , Andriano Tyler M. , Benesh Gabrielle , Babbush Kayla M. , Hosgood H. Dean , Campton Kristina L. , Cohen Steven R. 
Published: December 2022

Abstract
Introduction
Hidradenitis suppurativa (HS) is a chronic, debilitating skin condition that is characterized by painful pustules, nodules, abscesses, and sinus tracts. The complicated and fast-evolving treatment of HS consists of a multi-tiered approach that includes, antibacterial, antihormonal, anti-inflammatory, and surgical options. Studies have demonstrated an earlier age of onset and increased prevalence of HS in patients with intellectual and developmental disorders (IDD) compared to patients without IDD’s.
Objectives
To explore the use of an intensive multi-tiered HS management algorithm that requires monthly office visits, monthly intravenous therapy, and several daily treatment modalities in an HS population with IDD’s.
Methods
We conducted an IRB-approved retrospective chart review of HS patients treated at the Albert Einstein College of Medicine-Montefiore HS Center (HSC) with diagnoses of concurrent IDD to investigate their demographic and diagnostic characteristics, as well as the spectrum of therapies employed in this cohort.
Results
A total of 22 HS patients with concomitant IDD’s including trisomy 21, unspecified intellectual disability, autism spectrum disorder, and trisomy 13 were identified. Therapies utilized in this cohort for HS included topical and oral antibiotics, spironolactone, finasteride, oral contraceptive pills, infliximab, adalimumab, isotretinoin, intralesional and intramuscular triamcinolone injections, and excisional surgery.
Conclusion
In conclusion, our findings indicate that despite the practical challenges, daily oral antibiotic regimens, anti-androgen combinations, oral retinoids, infliximab, adalimumab, and surgery collectively play important roles in treating HS patients with IDD. Our cases underscore the importance of utilizing the full range of modalities as the HS treatment algorithm continues to evolve.
Extraction and surface modification of cellulose fibers and its reinforcement in starch-based film for packaging composites
Authors: Hafid Halimatun Saadiah , Omar Farah Nadia , Bahrin Ezyana Kamal , Wakisaka Minato 
Published: December 2022

Abstract
Cellulose extraction from gloss art paper (GAP) waste is a recycling strategy for the abundance of gloss art paper waste. Here, a study was conducted on the impact of ultrasonic homogenization for cellulose extraction from GAP waste to improve the particle size, crystallinity, and thermal stability. At treatment temperature of 75.8°C, ultrasonic power level of 70.3% and 1.4 h duration, cellulose with properties of 516.4 nm particle size, 71.5% crystallinity, and thermal stability of 355.2°C were extracted. Surface modification of cellulose GAP waste with H3PO4 hydrolysis and 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO) oxidation was done followed by starch reinforcement. Surface hydrophobicity and mechanical strength were increased for H3PO4 hydrolysis and TEMPO oxidation starch-cellulose. No reduction of thermal properties observed during the treatment, while increment of crystallinity index up to 47.65% - 59.6% was shown. Neat starch film was more transparent, followed by starch-TEMPO film and starch- H3PO4 film, due to better homogeneity. The cellulose GAP reinforced starch film shows potential in developing packaging materials and simultaneously provide an alternative solution of GAP waste recycling.
Similarity Analysis of Jet Wing Interaction Noise
Authors: Xu Xihai , Liu Junlin , Li Xiaodong 
Published: December 2022

Abstract
For deeper understanding of the mechanism of the jet wing interaction noise, and improving the current generation of aircraft noise prediction tools. An experimental study of jet installation effects is conducted in this paper by operating a cold jet with a Mach number range of 0.6 to 1.1. The experiment set-up consists of a flat plate placed in proximity to a jet. Installation effects cause low-frequency noise increase with respect to the isolated case, mainly occurring in the direction normal to the plate and upstream of the jet’s exit plane. Based on the similarity analysis of noise spectra, scaling laws are found for the far-field noise produced by different plate lengths and jet exit velocities. The sound intensity of the jet plate interaction noise scales with the third power of the jet velocity and fourth power of the turbulence length scale. And an effective Helmholtz number is proposed to replace Helmholtz number to normalize the jet plate inter action noise spectrum. Finally, a semi-empirical prediction model is proposed based on the similarity analysis. And the verification results show that the prediction model is capable of accurately predicting jet noise in a wide range of jet velocity and plate length.
Protein stability. Analysis of heat and cold denaturation without and with unfolding models
Authors: Seelig Joachim , Seelig Anna 
Published: December 2022

Abstract
Protein stability is of utmost importance in many areas of life sciences and life science technology. The gold standard for assessing protein stability is the measurement of the heat capacity Cp(T), showing large peaks at the temperature of cold and heat unfolding. We first demonstrate that important thermodynamic properties, including the free energy, can be obtained from Cp(T) temperature profiles without the necessity of an unfolding model. This is illustrated with experimental examples taken from the literature. We then compare all thermodynamic results with chemical and statistical unfolding models. An often-cited chemical equilibrium two-state model makes partially incorrect predictions. New models are introduced, which are in excellent agreement with the experimental results. We then show that the free energy is not a good criterion to judge protein stability. More useful parameters are discussed, including protein cooperativity. The new parameters are embedded in a well-defined thermodynamic context and are amenable to molecular dynamics calculations.
Stability of planar traveling waves for a class of Lotka-Volterra competition systems with time delay and nonlocal reaction term
Authors: Xue Yeqing , Ma Zhaohai , Liu Zhihua 
Published: December 2022

Abstract
In this paper, we consider the multidimensional stability of planar traveling waves for a class of Lotka-Volterra competition systems with time delay and nonlocal reaction term in n–dimensional space. It is proved that, all planar traveling waves with speed c > c* are exponentially stable in the form of t−n/2e−ϵτσt, where constant σ > 0 and ϵτ = ϵ(τ ) ∈ (0, 1) is a decreasing function for the time delay τ > 0. While, for the planar traveling waves with speed c = c*, we prove that they are algebraically stable in the form of t−n/2. The Fourier transform plays a crucial role in transforming the competition systems to a linear delayed differential system. We establish the comparison principle and some estimates in weighted spaces L1w(Rn) and Ww2,1(Rn) to obtain the main results.
Usability evaluation of connected health devices in home monitoring: Toward devices adapted to the characteristics of informal caregivers
Authors: Cardon Claire , Bernard Cécile I. , Chaniaud Noémie , Loup-Escande Emilie 
Published: December 2022

Abstract
While an increasing number of Informal CareGivers (ICGs) are assisting their dependent loved ones with the daily living tasks and medical care, they are rarely considered in the medical devices design process. The objective of this study is to identify the characteristics of ICGs impacting the use of the iHealth® Sense BP7 medical device, namely a connected wrist blood pressure monitor. For this purpose, user tests were conducted with 29 potential or actual ICGs. First, the participants filled out a socio-demographic questionnaire and then handled the blood pressure monitor. Finally, they completed the System Usability Scale questionnaire. The results revealed an impact of technophilia and age on usability dimensions. To conclude, the consideration of the ICG population in the design process of connected medical devices is discussed, particularly the age and level of technophilia.
Application of mathematical modeling to inform national malaria intervention planning in Nigeria
Authors: Ozodiegwu Ifeoma D. , Ambrose Monique , Galatas Beatriz , Runge Manuela , Nandi Aadrita , Okuneye Kamaldeen , Dhanoa Neena Parveen , Maikore Ibrahim , Uhomobhi Perpetua , Noor Abdisalan , Gerardin Jaline 
Published: December 2022

Abstract

BackgroundFor their 2021 – 2025 National Malaria Strategic Plan (NMSP), Nigeria’s National Malaria Elimination Program (NMEP), in partnership with the World Health Organization (WHO), developed a targeted approach to intervention deployment at the local government area (LGA) level as part of the High Burden to High Impact response. Mathematical models of malaria transmission were used to predict the impact of proposed intervention strategies on malaria burden.MethodsAn agent-based model ofPlasmodium falciparumtransmission was used to simulate malaria morbidity and mortality in Nigeria’s 774 LGAs under four possible intervention strategies from 2020 to 2030. The scenarios represented the previously implemented plan (business-as-usual), the NMSP at an 80% or higher coverage level and two prioritized plans according to the resources available to Nigeria. LGAs were clustered into 22 epidemiological archetypes using monthly rainfall, temperature suitability index, vector abundance, pre-2010 parasite prevalence, and pre-2010 vector control coverage. Routine incidence data were used to parameterize seasonality in each archetype. Each LGA’s baseline malaria transmission intensity was calibrated to parasite prevalence in children under the age of five years measured in the 2010 Malaria Indicator Survey (MIS). Intervention coverage in the 2010 - 2019 period was obtained from the Demographic and Health Survey, MIS, the NMEP, and post-campaign surveys.ResultsPursuing a business-as-usual strategy was projected to result in a 5% and 9% increase in malaria incidence in 2025 and 2030 compared with 2020, while deaths were projected to remain unchanged by 2030. The greatest intervention impact was associated with the NMSP scenario with 80% or greater coverage of standard interventions coupled with intermittent preventive treatment in infants and extension of seasonal malaria chemoprevention (SMC) to 404 LGAs, compared to 80 LGAs in 2019. The budget-prioritized scenario with SMC expansion to 310 LGAs, high bednet coverage with new formulations, and increase in effective case management rate at the same pace as historical levels was adopted as an adequate alternative for the resources available.ConclusionsDynamical models can be applied for relative assessment of the impact of intervention scenarios but improved subnational data collection systems are required to allow increased confidence in predictions at sub-national level.
Associations of cognition, mood symptoms, and brain regional homogeneity in patients with breast cancer with or without chemotherapy and healthy controls
Authors: Chen Vincent Chin-Hung , Hsu Yen-Hsuan , Weng Jun-Cheng , Wu Shu-I 
Published: December 2022

Abstract
Background
Cognitive impairments have long been a complaint from patients with BC. We hypothesized that presentations on Regional homogeneity (ReHo) from fMRI may be associated with relevant cognitive changes in patients with or without breast cancer and/or chemotherapy.
Methods
Neuropsychological assessments of cognitive functions, levels of depression, fatigue, and anxiety, as well as whole-brain MRI scans were administered in patients with newly diagnosed BC prior to and 3~9 months after receiving chemotherapy, as well as healthy controls without cancer. ReHo was calculated from fMRI data to determine synchronizations of local brain activity. Multivariate regression models adjusting for intelligence quotient (IQ), menopause, and mood symptoms, as well as mediation analyses using generalized structural equation modeling, were performed.
Results
In all, 51 participants (19 noncancer controls, 11 patients with BC before chemotherapy, and 21 patients with BC who finished chemotherapy) completed the neuropsychological assessments and MRI. Significant differences in IQ and ReHo from several brain areas were observed in the three subgroups. Predictors for each domain of neurocognitive testing differed among the subgroups. Brain synchronization from the right middle frontal area was found to have significant mediating effect between chemotherapy status and the first part of Color Trails Test (CTT1) in the pre-C/T subgroup.
Conclusion
Differing from our expectations, the effects that the status of chemotherapy had on neurocognitive function assessed by CTT1 was mediated by ReHo in the right middle frontal area individually and not in sequential order with any mood symptoms.
Lipopolysaccharide pretreated bone marrow mesenchymal stem cells derived exosomes promote M2 macrophage polarization through CCN3/NOTCH1 pathway
Authors: Sha Yuxia , Liu Jia , Zhou Haoquan 
Published: December 2022

Abstract

Background and Objectives:Exosomes secreted by bone marrow mesenchymal stem cells (BMSCs) pretreated with lipopolysaccharide (LPS) (L-Exo) exert a stronger anti-inflammatory effect than exosomes derived from BMSCs (Exo); exosomes are likely to exert biological effects through carrier proteins. This study aimed to investigate whether L-Exo reduces the inflammatory response after sepsis by overexpressing a specific protein.Methods:The effects of L-Exo and Exo in the treatment of sepsis models in vitro (LPS stimulating Raw264.7) were compared, and their differential proteins were analyzed by mass spectrometry. The mechanism of anti-inflammatory effect of proteins carried by exosomes was evaluated by Western blot, qRT-PCR, ELISA, cell transfection, and TUNEL.Results:ELISA showed that the concentration of TNF-a in the supernatant of septic model treated with L-Exo (131.60 mg/mL) was lower than that in the Exo group (170.85 mg/mL). WB and qRT-PCR showed that the expression of TNF-a and iNOS protein was lowest in the L-Exo group, but no obvious apoptotic cells were detected in TUNEL staining. A total of 154 proteins with significant differences were obtained; CCN3 is one of the upregulated differential proteins. In this study, we verified L-Exo’s anti-inflammatory effect by downregulating NOTCH1 signal to promote M2 polarization via cell transfection and qRT-PCR.Conclusion:L-Exo exerts an anti-inflammatory effect by promoting macrophages polarization to M2 through CCN3/NOTCH1 pathway but is not related to macrophage apoptosis pathway.
Existence and asymptotic behavior of square-mean S-asymptotically periodic solutions of fractional stochastic evolution equations
Authors: Li Qiang , Liu Lishan 
Published: December 2022

Abstract
This paper investigates the abstract fractional stochastic evolution equations. A new existence result of the square-mean S-asymptotically periodic mild solutions are obtained under the assumption that the nonlinear terms only satisfy some growth conditions. Moreover, the uniqueness and asymptotic stability results of the square-mean S-asymptotically periodic solution are presented when the nonlinear functions satisfy the general Lipschitz condition. Finally, two examples are given to illustrate our main results.
MR(2020) Subject Classification: 60H15; 47D06; 34G20; 46T20.
Magnetic resonance spectroscopy investigation in the human hippocampus following spinal cord injury
Authors: Pfyffer Dario , Zimmermann Sandra , Şimşek Kadir , Kreis Roland , Freund Patrick , Seif Maryam 
Published: December 2022

Abstract
Objective
Preclinical studies have shown that cognitive impairments following spinal cord injury (SCI), such as impaired spatial memory, are linked to inflammation, neurodegeneration, and reduced neurogenesis in the right hippocampus. This cross-sectional study aims to characterize metabolic and macrostructural changes in the right hippocampus and their association to cognitive function in traumatic SCI patients.
Methods
Within this cross-sectional study, cognitive function was assessed in 28 chronic traumatic SCI patients and 18 age-, sex-, and education-matched healthy controls by a visuospatial and verbal memory test. A magnetic resonance spectroscopy (MRS) and structural MRI protocol was performed in the right hippocampus of both groups to quantify metabolic concentrations and hippocampal volume, respectively. Group comparisons investigated changes between SCI patients and healthy controls and correlation analyses investigated their relationship to memory performance.
Results
Memory performance was similar in SCI patients and healthy controls. The quality of the recorded MR spectra was excellent in comparison to the best-practice reports for the hippocampus. Metabolite concentrations and volume of the hippocampus measured based on MRS and MRI were not different between two groups. Memory performance in SCI patients and healthy controls was not correlated with metabolic or structural measures.
Conclusions
This study suggests that the hippocampus may not be pathologically affected at a functional, metabolic, and macrostructural level in chronic SCI. This points towards the absence of significant and clinically relevant trauma-induced neurodegeneration in the hippocampus.
Construction of wavelet boundary element method for solving SIFs of two-dimensional plates
Authors: Yuan Dongjie , Xiang Jiawei 
Published: December 2022

Abstract
Using one-dimensional (1D) scaling functions of B-spline wavelet on the interval (BSWI) as the interpolation functions, a wavelet boundary element method (WBEM) is presented to solve stress intensity factors (SIFs) for two-dimensional (2D) plates with singular stress fields. Firstly, to discrete the geometrical boundary, 1D wavelet-based elements are employed through the non-singular transformation matrices to transfer coefficients of wavelets expansions in the wavelet space to the physical space. The crack plate with symmetry is simplified according to symmetric conditions, and the asymmetric crack plate is divided into several subdomains to be solved according to the conditions of displacements continuity and traction equilibrium. Secondly, for the singular integrals in the WBEM, the gaussian integral and logarithmic gaussian integral are used to solve its by coordinate transformation matrices. Meanwhile, BSWI elements with good approximation characteristics and multi-resolution contain local asymptotic behavior of the stress fields at the tip of a crack, and can thus appropriately describe the singular near-tip stress fields for cracked plates. Finally, SIFs of crack tip are obtained by fitting the crack opening displacement. The performance of the method is investigated through the comparison of the results with six numerical cases of the plane stress elastic and bi-material plates.
Rational index of languages defined by grammars with bounded dimension of parse trees
Authors: Shemetova Ekaterina , Okhotin Alexander , Grigorev Semyon 
Published: December 2022

Abstract
The rational index \rho_L of a language L is an integer function, where \rho_L is the maximum length of the shortest string in L \cap R, over all regular languages R recognized by n-state nondeterministic finite automata (NFA). This paper investigates the rational index of languages defined by grammars with bounded tree dimension, and shows that itis polynomial in n. More precisely, it is proved that for a context-free grammar with tree dimension bounded by d, its rational index is at most O(n^{2d}), and that this estimation is asymptotically tight, as there exists a grammar with rational index \Theta(n^{2d}). For a multi-component grammar of rank k and with tree dimension bounded by d, the rational index is bounded by O(n^{2kd}), and there exists a grammar with rational index \Omega(n^{2kd}).
Green's function in general relativity
Authors: Kurihara Yoshimasa 
Published: December 2022

Abstract
This report provides Green's functions (propagators) of gravitational fields of vierbein and connection fields in general relativity. The existence of Green's function of the Laplace operator in curved space with an indefinite metric is ensured owing to the Hodge harmonic analysis. The analyticity of Green's function is naturally fixed intrinsically, keeping a causality. This report proposed a novel definition of the momentum space in curved space-time and the linearisation of the Einstein equation as a free field consistent with that for the Yang-Mills gauge field. The proposed linearisation does not utilize the weak-field approximation; thus, the method is applicable for highly caved space-time. We gave two examples of Green's function of gravitational fields, the plane wave solution and the Schwarzschild solution.
The Hidden Bioeconomic Face of Covid-19 Pandemic A Dilemma and Paradox of Logic
Authors: Kolo Kamal , Aspoukeh Peyman , Abdullah Milad 
Published: December 2022

Abstract
It is surprisingly simple and paradoxical that Covid-19 pandemic shows a specific tendency to be an economy-related and driven pandemic. Countries with higher Gross Domestic Product (GDP), incurred more cases of infection and mortalities such a way that a steady trend emerges: those most affected are the richest amongst the rich, and the richer amongst the poorer. Surprisingly, the a country’s healthcare system integrity level seems to be a less relevant factor or even a nonfactor. Countries with low GDP and weak healthcare system manifested the lowest numbers of infection and death cases all around the world. This work is based on statistical data analysis and correlation between infection and mortality cases as per country, region, continent and provinces within countries with the Gross Domestic Product (GDP). A specific strong positive correlation between the GDP of a certain country/province, region and the number of infection and mortalities emerged. This relationship is validated for Europe, USA, Latin America, Asia, Africa and the Middle East. This inter-dependent relationship holds paradoxical elements as it stands against the common wisdom that a country or group of countries with higher Epidemic Preparedness Index (EPI) and development, the less exposed to pandemics are. This has been shown not to be case with Covid-19. In fact, it is the opposite. This work sees embedded factors related to Bioeconomics, socio-cultural factors that determined this relationship. It is a phenomenon worthy of more analysis and more specific data related to ethnicities, genetics, socio-cultural and Bioeconomics.