bluuebunny/crossref_metadata_2025_split huggingface dataset:
EVALUATION AND COMPREHENSIVE COMPARISON OF OCTADECYLAMINE AND STEARAMIDE-BASED SOLID LIPID NANOPARTICLES FOR EFFICIENT GENE DELIVERY
Authors: Kirmizitaş Fatma Ceren , Varlı Hanife Sevgi , Türkoglu Nelisa 
Published: July 2022

In recent years various nonviral vector systems have been developed to overcome the disadvantages of viral vectors. Thus, researchers have turned to more secure and easy to reach vector systems. In this study, we have evaluated the gene transfer efficiency of two different nonviral vectors prepared using two lipids: octadecylamine and stearamide. The solid lipid nanoparticles were produced with the emulsion-solvent evaporation method. Particles' mean size, polydispersity index (PDI), and zeta potential values for octadecylamine nanoparticle (ONP) are, respectively, 382.7 nm (&#177; 20), 0.4, and 28 mV (&#177;

2.03)	and for stearamide nanoparticle (SNP) are 276.9 nm (&#177; 10.45), 0.3, and 20.4 mV (&#177; 4.03), as determined by using Zetasizer via the dynamic light scattering (DLS) method. Morphological characterization of nanoparticles was performed with scanning electron microscope (SEM) and atomic force microscope (AFM). The chemical characterization was performed by Fourier-transform infrared spectroscopy (FTIR). The cytotoxicity of nanoparticles were determined via 3-(4,5-Dimethylthiazol)-2,5-diphenyltetrazolium bromide (MTT) assay with an MCF-7 human breast cancer cell line. The cytotoxicity for both ONP and SNP were calculated over 55&#37;. Also nanoparticles/plasmid DNA conjugates cytotoxicity were determined with no significant toxicity obtained. The transfection efficiency was evaluated by observing green fluorescent protein (GFP) expression in the MCF-7 human breast cancer cell line. The transfection efficiency was 67.5&#37; (&#177; 2.3) for ONP, 77.6&#37; (&#177; 1.2) for SNP, and 70.7&#37; (&#177; 1.4)	for commercially available transfection agent.
Measuring expertise in identifying interictal epileptiform discharges
Authors: Harid Nitish M. , Jing Jin , Hogan Jacob , Nascimento Fábio A. , Ouyang An , Zheng Wei‐Long , Ge Wendong , Zafar Sahar F. , Kim Jennifer A. , Alice D. Lam , Herlopian Aline , Maus Douglas , Karakis Ioannis , Ng Marcus , Hong Shenda , Yu Zhu , Kaplan Peter W. , Cash Sydney , Shafi Mouhsin , Martz Gabriel , Halford Jonathan J. , Westover Michael Brandon 
Published: July 2022

AbstractObjective. Interictal epileptiform discharges on EEG are integral to diagnosing epilepsy. However, EEGs are interpreted by readers with and without specialty training, and there is no accepted method to assess skill in interpretation. We aimed to develop a test to quantify IED recognition skills.Methods. A total of 13,262 candidate IEDs were selected from EEGs and scored by eight fellowship‐trained reviewers to establish a gold standard. An online test was developed to assess how well readers with different training levels could distinguish candidate waveforms. Sensitivity, false positive rate and calibration were calculated for each reader. A simple mathematical model was developed to estimate each reader's skill and threshold in identifying an IED, and to develop receiver operating characteristics curves for each reader. We investigated the number of IEDs needed to measure skill level with acceptable precision.Results. Twenty‐nine raters completed the test; nine experts, seven experienced non‐experts and thirteen novices. Median calibration errors for experts, experienced non‐experts and novices were ‐0.056, 0.012, 0.046; median sensitivities were 0.800, 0.811, 0.715; and median false positive rates were 0.177, 0.272, 0.396, respectively. The number of test questions needed to measure those scores was 549. Our analysis identiﬁed that novices had a higher noise level (uncertainty) compared to experienced non‐experts and experts. Using calculated noise and threshold levels, receiver operating curves were created, showing increasing median area under the curve from novices (0.735), to experienced non‐experts (0.852) and experts (0.891).Significance. Expert and non‐expert readers can be distinguished based on ability to identify IEDs. This type of assessment could also be used to identify and correct differences in thresholds in identifying IEDs.
Differential impact of antenatal exposure to antiseizure medications on motor and mental development in infants of women with epilepsy
Authors: Thomas Sanjeev V. , Jeemon Panniyammakal , Jose Manna , Amrithum Lekshmi Madhavan , Bhaskar Deepa , Nair Muttathu Krishnapanicker Chandrasekharan , George Babu 
Published: July 2022

AbstractObjective. We aimed to determine a possible association between motor and mental development in infants of women with epilepsy and antenatal exposure to antiseizure medication (ASM).Methods. Developmental paediatricians who were blinded to antenatal ASM exposure evaluated motor and mental development of infants (>12 months) using the Developmental Assessment Scale for Indian Infants (an Indian adaptation of the Bayley Scale of Infant Development). Motor (MODQ) and mental development quotients (MEDQ) were computed as ratios of respective developmental age to the chronological age of the child. We employed linear mixed models to study the relationship between antenatal exposure to ASM and the development quotients after adjustment for malformation status and age of the baby, maternal education and seizure type.Results. We studied 1,357 infants with mean age of 15.3±4.0 months (71.2% of all eligible infants). Infants were classified as having monotherapy or polytherapy, or unexposed in 840, 407 and 110 participants, respectively. The MEDQ of the polytherapy (92.9±14.9) and monotherapy (96.9±13.9) groups was lower than that of unexposed infants (99.8 12.5). Similarly, the MODQ of polytherapy (91.1±19.3) and monotherapy (96.6±17.5) groups was lower than that of unexposed infants (97.6 16.6). The differences in adjusted mean MEDQ were ‐7.4 (‐11.4 to ‐4.3, p=0.001), ‐9.6 (‐11.3 to ‐6.0, p=0.001) and ‐6.4 (‐9.2 to ‐3.7, p=0.001) for valproate monotherapy, polytherapy with valproate and polytherapy without valproate, respectively. The adjusted mean MODQ also showed a similar trend. Those exposed to levetiracetam (n=62) had higher or similar adjusted MODQ (110.4±14.3; p=0.001) and MEDQ (104.3±9.1; p=0.09), compared to unexposed infants. A dose‐dependent decrease in developmental indicators was observed for valproate and phenobarbitone.Significance. Antenatal exposure to ASM, especially valproate and phenobarbitone, adversely affects motor and mental development of exposed infants. Early developmental screening of high‐risk infants is desirable.
SAĞLIK ÇALIŞANLARININ COVID-19 PANDEMİSİ DÖNEMİNDE UYKU KALİTESİNİN ARAŞTIRILMASI
Authors: KURT Yücel , SAYGIN Mustafa 
Published: July 2022

Amaç
Bu çalışma, hastane çalışanlarında, pandemi döneminde
yoğun iş temposu ile uyku kalitesi arasındaki
ilişkinin araştırılması amacıyla yapıldı.
Gereç ve Yöntem
Kesitsel tipteki araştırmamıza hastanede çalışan sağlık
çalışanları dahil edildi. Veriler hastanede pandemi
sürecinde aktif olarak görev alan personele; Tanıtıcı
Anket Formu, Pandemi Değerlendirme Anketi ve Pittsburg
Uyku Kalitesi İndeksi kullanılarak elde edildi.
Verilerin değerlendirilmesinde; tanımlayıcı istatistik,
ki-kare, korelasyon, t testi ve tek yönlü varyans analizi
(ANOVA) kullanıldı.
Bulgular
Çalışmamıza hemşire, sağlık teknisyeni, doktor, idari
personel ve temizlik personelinden oluşan toplam 103
sağlık çalışanı (Erkek: 36 (%35), Kadın: 67 (%65)) katıldı.
Çalışanların görev süresi ortalaması 14,12±9,73
yıl olarak saptandı. Sağlık profesyonellerinin vücut
kitle indeksi (VKİ) erkek: 26,33±3,13 kg/m2, kadın:
24,07±3,70 kg/m2 olarak bulundu. Çalışmamıza katılan
sağlık profesyonellerinin çoğunluğu cerrahi Bölümde
(25 (%24,3)), yoğun Bakımda (19 (%18,4), acil
serviste (15 (%14,6)) ve idari kısımda (13 (%12,6)) çalışmaktaydı.
Geri kalanları laboratuvarda (9 (%8,7)),
COVID-19 polikliniğinde (7 (%6,8)), ve diyalizde (5
(%4,9)) çalışmaktaydı. Pandemi öncesi uyku bozukluğu
ve buna bağlı olarak ilaç kullanım oranı düşüktü.
Pandemi sürecinde; sağlık profesyonellerinde Hemşire
ve Temizlik Personeli arasında istatistiksel olarak
anlamlı farklılık vardı ve PUKİ puanları Hemşirelerde
yüksek bulundu (p=0,002).
Sonuç
Pandemi döneminde hastane çalışanlarında uyku
kalitesinin artan iş yükü ile beraber azaldığı ve artan
kaygı düzeyleri ile beraber sağlık çalışanlarının yaşamını
olumsuz etkilediği saptandı.
DevelNet: Earthquake Detection on Develocorder Films with Deep Learning: Application to the Rangely Earthquake Control Experiment
Authors: Wang Kaiwen , Ellsworth William , Beroza Gregory C. , Zhu Weiqiang , Rubinstein Justin L. 
Published: July 2022

Abstract
There exists over a century of instrumental seismic data; however, most seismograms recorded before the 1980s are only available in analog form. Although analog seismograms are of great value, they are underutilized due to the difficulties of making quantitative measurements on the original media and in converting them to digital time series. In this study, we present an alternative workflow, based on deep learning, to reconstruct an earthquake catalog from images of analog data without conversion to vector time series. We trained a convolutional neural network—DevelNet, using synthetic analog data to detect earthquakes on scanned multichannel Develocorder film images. We then developed an image-based processing workflow to measure arrival times, locate, and determine the magnitudes of earthquakes in the data. We demonstrate the performance of this approach on two years of continuous Develocorder film recordings from the Rangely earthquake control experiment in the mid-1970s. Our approach detects twice the number of events reported in the original catalog (Raleigh et al., 1976). This demonstrates that DevelNet efficiently detects earthquakes from Develocorder film scans, performs consistently over time, and is robust to changes in network geometry. Our locations generally agree with the original study, although the automatically measured arrival times are less precise than manual reading, leading to increased location scatter. Our automatic workflow of Develocorder films rivals the performance of skilled analysts in earthquake detection, but with minimal human intervention. This image-based processing offers a new approach for effectively and efficiently extracting earthquake information from analog seismic data.
Biological control of invasive Dryocosmus kuriphilus with introduced parasitoid Torymus sinensis in Croatia, Slovenia and Hungary
Authors: Matosevic Dinka , Lacković Nikola , Melika George , Kos Katarina , Franić Iva , Kriston Eva , Boszo Miklos , Seljak Gabrijel , Rot Mojca 
Published: July 2022

Background and purpose: Dryocosmus kuriphilus is considered as one of the major pests of sweet chestnut and the effective method of controlling its populations and damage is the biological control with its introduced parasitoid Torymus sinensis. T. sinensis is a univoltine, host specific parasitoid, phenologically synchronized and morphologically adapted to D. kuriphilus. It has a good dispersal ability, it builds up populations quickly and it effectively controls the pest already few years after the release. In this paper we describe the first results of the introduction and release of T. sinensis for controlling the populations of invasive D. kuriphilus in sweet chestnut forests and orchards in Croatia, Hungary and Slovenia. Materials and methods: Withered D. kuriphilus galls with T. sinensis larvae were collected in Torino vicinities, Italy, in March 2014 and March 2015. After emergence, males and females were put together, kept at 14°C and fed with liquid honey until the release. To confirm the establishment of the population of T. sinensis on release site from 2014 in Croatia morphological and DNA identification were used. Fresh galls from the release site of Pazin, Croatia were collected in spring 2015 and parasitism rates of T. sinensis were calculated. Results and conclusions: In total 10,590 females and 5,295 males of T. sinensis were released in sweet chestnut forests in Croatia, Hungary and Slovenia in 2014 and 2015. The minimum release number of T. sinensis was 100 females/50 males and the maximum was 1,200 females per site. Subsequent releases with a larger number of females (1,200 and 800 in two years) resulted in a rapid establishment of the population of T. sinensis and parasitism rates of 76% only one year after the first release was done. The establishment of the population of T. sinensis was confirmed with molecular analyses and morphological identification. Obtained haplotype sequences of T. sinensis have shown similarities with Torymus beneficus. Prior to the release of T. sinensis, all advantages and disadvantages of the introduction of this alien biocontrol species into natural stands in Croatia, Hungary and Slovenia have been considered.
Small-scale farmers’ willingness to adopt chemical-free inputs and engage in collaborative arrangements –A discrete choice experiment in Central Mexico
Authors: Colin Castillo Sergio , Manríquez García Naím , Martinez-Cruz Adan L. 
Published: July 2022

Objetive: Explore small-scale Mexican farmers’ willingness to adopt chemical-free fertilizers and pesticides, and to engage in two collaborative arrangements.

Methodology: A discrete choice experiment has been designed based on two non-monetary attributes (use/no use of chemical inputs and two collaborative arrangements) and a monetary attribute (percentage change in price of crop that generates most of net revenues). Data has been analyzed with a two-class latent class logit specification.

Findings: 60% of respondents is not willing to transition to a chemical-free input regime, is willing to receive management support from municipality, and is not interested in a shared insurance. On the opposite side of the preferences, 40% of respondents is willing to adopt chemical-free inputs, is not interested in management support, and is willing to participate in a shared insurance.

Limitations: Our sample is not nationally representative, and further studies are needed to corroborate and generalize our findings.

Contribution: This is the first study exploring whether preferences of small-scale farmers in Mexico align with Federal government’s goal of phasing out glyphosate.

Conclusions: With 40% of small-scale farmers willing to adopt chemical-free inputs, if the Federal government wants to convice the other 60% of phasing out glyphosate, a possibility is to implement a slower strategy that starts with providing management support. Once management support is in place, and trust is gained, doors may open for a transition to chemical-free production regimes.
SIMULASI AKTIVITAS KESTABILAN INTI PELURUHAN DERET NEPTUNIUM DENGAN PENDEKATAN ENERGI IKAT INTI MODEL TETES CAIRAN
Authors: Febriandina Auralia , Prihandono Trapsilo , Lesmono Albertus Djoko 
Published: July 2022

The purpose of this study was to calculate the activity, binding energy, and disintegration energy produced by the decay of radioactive substances in the Neptunium series based on the liquid drop core model. The research steps: 1) prepare supporting data for research on activity and binding energy on nuclear stability decay; 2) review the material that has been obtained; 3) perform calculation simulations; 4) analyze and discuss the calculation results; 5) conclude the research results. The conclusion in this study is that the activity value has increased linearly with a range of values ​​from Bq to Bq. The binding energy decreased linearly with values ​​ranging from 1797.4088 MeV to 1627.7112 MeV. Meanwhile, the binding energy of the nucleons increases linearly. The disintegration energy in the Neptunium series has the largest positive value (Q>0) of 5.2712 MeV and the smallest disintegration energy of Radium-225 which is -0.4317 MeV.
Keyword : The activity, binding energy, liquid drop model
Strategi Pengembangan Obyek Wisata Bukit Matang Kaladan Terhadap Pendapatan Asli Desa Tiwingan Lama Kabupaten Banjar
Authors: Hadadi Nurahman , Muzdalifah Muzdalifah 
Published: July 2022

This study aims to (1) develop strategies that need to be carried out in developing Bukit Matang Kaladan Tourism Object, (2) know the contribution of Bukit Matang Kaladan Tourism Object to the village's original income, and (3) know the role of government in developing Bukit Matang Tourism Object Kaladan. Respondents in this study were six respondents who were considered influential and experts. They knew the tourism situation, especially in Banjar District, which was used in data processing using the SWOT method. This study provides the results of developing the strategy that best suits the situation is the SO strategy (1) With the superiority of the landscape and maintaining a conducive tourist environment; tourists will continue to visit these attractions, plus a strategic location. (2) Maximizing the role of POKDARWIS and training provided by the Banjar Regency Culture and Tourism Office to promote tourism objects with the opportunities that are already available.
Pengaruh Indeks Pembangunan Manusia, Pendapatan Perkapita Dan Pertumbuhan Ekonomi Terhadap Kemiskinan Di Kabupaten Hulu Sungai Selatan Tahun 2005-2019
Authors: Sinta Sinta , Fahrati Eny 
Published: July 2022

This study aims to determine the effect of the human development index, per capita income, and economic growth on poverty in the Hulu Sungai Selatan regency from 2005-to 2019. This research is included in quantitative research, and the method used is multiple linear regression using time series secondary data processed with the help of the SPSS-26.0 program. The results of this study (1) The variables of Human Development Index, Per capita Income, and Economic Growth have a simultaneous effect on poverty in Hulu Sungai Selatan Regency. (1) The most dominant factor is the Per capita Income variable. To accelerate the decline in the poverty rate, it is necessary to increase economic activity in all sectors, especially potential sectors such as agriculture, mining, trade, and government, and improve the quality of knowledge and skills so that the amount of Gross Regional Domestic Product generated can support people's income.
KETAHANAN KAYU DURIAN (Durio zibethinus MURR) DAN KAYU KARET (Hevea brsiliensis) TERHADAP SERANGAN RAYAP TANAH YANG DIAWETKAN DENGAN DAUN SEREH DAPUR (Cymbopogon citrates)
Authors: Susanti Susanti , Ulfah Diana , Lusyiani Lusyiani 
Published: July 2022

The purpose of this research is to anaIyze the degree of damage to 2 types of wood preserved with kitchen lemongrass preservatives against subterranean termites. Data anaIysis was performed to caIculate absorption and retention using a compIeteIy srandomized design with 4 treatments and 5 replications using 2 types of wood, so that the number of sampIes is 40 and each type of wood is as many as 20 sampIes. Theresults showed that the value of the degree of damage to durian wood and rubber wood preserved with kitchen lemongrass experienced mild attacks on average. The value of the degree of wood damage is obtained by first knoing the percentage of wood weight Ioss, the smaIIer the reduction in wood weight the better the effectiveness of the preservative. Degree of damage to durian wood and rubber wood preserved with Iemongrass the average experienced a miId attack with the highest value of durian wood at 100gr treatment of 28,43% and the Iowest was at 300gr treatment at 6,21%. While for rubber wood the highest value was at 100gr treatment of 38,34% and the Iowest at 300gr treatment of 20,89%. The type of subterranean termite that attacks durian wood an rubber wood is a type of subterranean termite Macrotermes gilvusI.Tujuan peneIitian ini adaIah untuk MenganaIisis derajat kerusakan 2 jenis kayu yang diawetkan dengan bahan pengawet sereh dapur terhadap serangan rayap tanah. AnaIisis data diIakukan untuk menghitung absorbsi dan retensi dangan menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 5 ulangan menggunakan 2 jenis kayu, sehingga jumlah sampel sebanyak 40 buah dan masing-masing jenis kayu sebanyak 20 sampel uji. HasiI peneIitian menunjukkan bahwa Nilai derajat kerusakan kayu durian dan kayu karet yang diawetkan dengan sereh dapur rata-rata mengalami serangan ringan. Pada kayu durian derajat kerusakan tertinggi terdapat perIakuan 100gr sebesar 28,43% dan terendah pada perIakuan 300gr sebesar 6,21% sedangkan kayu karet nilai tertinggi pada perIakuan 100 gr sebesar 38,34% dan terendah pada perIakuan 300 gr sebesar 20,89%. Nilai derajar kerusakan kayu didapatkan dengan terlebih dahulu mengatahui persentase kehilangan berat kayu, semakin kecil pengurangan berat kayu semakin bagus efektivitas bahan pengawet. Jenis rayap tanah yang menyerang kayu durian dan kayu karet adaIah jenis rayap tanah Macrotermes gilvus
PRODUKTIVITAS DAN RENDEMEN KERAJINAN ANYAMAN BAMBAN (Donax canniformis) TERHADAP KONTRIBUSI PENDAPATAN PENGRAJIN DI DESA TANAH HABANG KECAMATAN LAMPIHONG KABUPATEN BALANGAN
Authors: Nandya Rizqa Ilma , Violet Violet , Abidin Zainal 
Published: July 2022

This study aims to determine and analyze the productivity, yield and income contribution of Bamban handicrafts in the form of bags and wallets for the community in Tanah Habang Village, Lampihong District, Balangan Regency. The method used is direct observation at the site of the investigation and the interview method of the Bamban weavers as well as the use of the census method taken 100% of the 17 Bamban weavers in Tanah Habang village. The results of this study indicate that the average time needed for craftsmen to make bags is 1.83 hours, while the average time needed to make wallets is 1.08. The yield from Bamban Bags ranged from 63.38% to 80.98%, with the average yield from Bamban Bags being 71.2% while the average yield from Bamban Bags was 77.25%. The average income contribution of artisans to Bamban weaving is 66% and there are three people with 100% contribution, namely Saripah, Riana and IsmiPenelitian ini bertujuan untuk mengetahui dan menganalisis besarnya produktivitas, rendemen dan kontribusi terhadap pendapatan kerajinan Bamban berupa tas dan dompet bagi masyarakat di Desa Tanah Habang Kecamatan Lampihong Kabupaten Balangan. Metode yang digunakan adalah observasi langsung di lokasi penelitian dan metode wawancara terhadap pengrajin anyaman Bamban dan menggunakan metode sensus yang di ambil 100% dari 17 orang pengrajin anyaman Bamban di Desa Tanah Habang. Hasil yang diperoleh dari penelitian ini bahwa rerata waktu yang diperlukan pengrajin untuk menghasilkan satu buah Tas yaitu 1,83 jam sedangkan rerata untuk membuat satu buah Dompet yaitu 1,08. Rendemen Tas Bamban berkisar antara 63,38% - 80,98% dengan rerata rendemen Tas Bamban yaitu 71,2%, sedangkan untuk rerata rendemen Dompet Bamban yaitu 77,25%. Rerata kontribusi pendapatan pengrajin terhadap anyaman Bamban sebesar 66% dan terdapat tiga orang dengan kontribusi 100% yaitu pada responden Saripah, Riana, dan Ismi.