bluuebunny/crossref_metadata_2025_split huggingface dataset:
miRNA-486-5p: signaling targets and role in non-malignant disease
Authors: Douvris Adrianna , Viñas Jose , Burns Kevin D. 
Published: June 2022

AbstractMicroRNAs (miRNAs) are short non-coding RNAs, highly conserved between species, that are powerful regulators of gene expression. Aberrant expression of miRNAs alters biological processes and pathways linked to human disease. miR-486-5p is a muscle-enriched miRNA localized to the cytoplasm and nucleus, and is highly abundant in human plasma and enriched in small extracellular vesicles. Studies of malignant and non-malignant diseases, including kidney diseases, have found correlations with circulating miR-486-5p levels, supporting its role as a potential biomarker. Pre-clinical studies of non-malignant diseases have identified miR-486-5p targets that regulate major signaling pathways involved in cellular proliferation, migration, angiogenesis, and apoptosis. Validated miR-486-5p targets include phosphatase and tensin homolog (PTEN) and FoXO1, whose suppression activates phosphatidyl inositol-3-kinase (PI3K)/Akt signaling. Targeting of Smad1/2/4 and IGF-1 by miR-486-5p inhibits transforming growth factor (TGF)-β and insulin-like growth factor-1 (IGF-1) signaling, respectively. Other miR-486-5p targets include matrix metalloproteinase-19 (MMP-19), Sp5, histone acetyltransferase 1 (HAT1), and nuclear factor of activated T cells-5 (NFAT5). In this review, we examine the biogenesis, regulation, validated gene targets and biological effects of miR-486-5p in non-malignant diseases.
Convergence rates of a dual gradient method for constrained linear ill-posed problems
Authors: Jin Qinian 
Published: June 2022

AbstractIn this paper we consider a dual gradient method for solving linear ill-posed problems $$Ax = y$$

A
x
=
y

, where $$A : X \rightarrow Y$$

A
:
X
→
Y

is a bounded linear operator from a Banach space X to a Hilbert space Y. A strongly convex penalty function is used in the method to select a solution with desired feature. Under variational source conditions on the sought solution, convergence rates are derived when the method is terminated by either an a priori stopping rule or the discrepancy principle. We also consider an acceleration of the method as well as its various applications.
Second-Order Finite Automata
Authors: de Melo Alexsander Andrade , de Oliveira Oliveira Mateus 
Published: June 2022

AbstractTraditionally, finite automata theory has been used as a framework for the representation of possibly infinite sets of strings. In this work, we introduce the notion of second-order finite automata, a formalism that combines finite automata with ordered decision diagrams, with the aim of representing possibly infinitesets of setsof strings. Our main result states that second-order finite automata can be canonized with respect to the second-order languages they represent. Using this canonization result, we show that sets of sets of strings represented by second-order finite automata are closed under the usual Boolean operations, such as union, intersection, difference and even under a suitable notion of complementation. Additionally, emptiness of intersection and inclusion are decidable. We provide two algorithmic applications for second-order automata. First, we show that several width/size minimization problems for deterministic and nondeterministic ODDs are solvable in fixed-parameter tractable time when parameterized by the width of the input ODD. In particular, our results imply FPT algorithms for corresponding width/size minimization problems for ordered binary decision diagrams (OBDDs) with a fixed variable ordering. Previously, only algorithms that take exponential time in the size of the input OBDD were known for width minimization, even for OBDDs of constant width. Second, we show that for eachkandwone can count the number of distinct functions computable by ODDs of width at mostwand lengthkin timeh(|Σ|,w) ⋅kO(1), for a suitable$h:\mathbb {N}\times \mathbb {N}\rightarrow \mathbb {N}$h:ℕ×ℕ→ℕ. This improves exponentially on the time necessary to explicitly enumerate all such functions, which is exponential in both the width parameterwand in the lengthkof the ODDs.
Hospitalisations related to benzodiazepine, Z-drug, and opioid treatment in Italy: a claim on the risks associated with inappropriate use
Authors: Mattioli Irene , Bettiol Alessandra , Crescioli Giada , Bonaiuti Roberto , Prisco Domenico , Mannaioni Guido , Lombardi Niccolò , Vannacci Alfredo ,   the MEREAFaPS Study group
Published: June 2022

Abstract
Purpose
Benzodiazepines (BZD), Z-drugs (ZD), and opioids share a high risk of abuse. This study assessed and characterised adverse events (AEs) related to BDZ, ZD, and opioids leading to emergency department (ED) visits in the Italian setting.

Methods
ED accesses related to BDZ, ZD, and/or opioids were analysed from the MEREAFaPS database. Information on AEs, suspected and concomitant medications was retrieved. Multivariate logistic regression was used to estimate the reporting odds ratios (RORs) of hospitalisation according to the different treatments.

Results
A total of 5,970 pharmacovigilance reports involving BZD/ZD (n = 3,106), opioids (n = 2,767), or their combination (n = 97) were analysed. Compared to opioids, patients with BZD/ZD-related AEs were often younger (51 vs 64 years), more frequently presented 2+ suspected medications (13 vs 3%), and often had a history of abuse (4%). Twenty-three percent of BZD/ZD-related AEs were related to drug abuse (vs 2% of opioid-related ones) and frequently required patient hospitalisation (52% vs 24%), despite the significantly lower clinical complexity of these patients as compared to those on opioids. An increased risk of hospitalisation was found for flurazepam (ROR 1.62; 95% CI, 1.18–2.22), prazepam (2.66; 1.05–6.70), lorazepam (1.26; 1.07–1.49), and morphine (1.76; 1.11–2.79).

Conclusions
These results indicate that, in Italy, the inappropriate use of BZD/ZD is a relevant heath issue, often leading to serious AEs requiring patients’ ED visits and hospitalisation, especially in young women and patients with a history of substance abuse.
Treatment during cerebral vasospasm phase—complication association and outcome in aneurysmal subarachnoid haemorrhage
Authors: Hostettler Isabel C. , Kreiser Kornelia , Lange Nicole , Schwendinger Nina , Trost Dominik , Frangoulis Samira , Hirle Theresa , Gempt Jens , Wostrack Maria , Meyer Bernhard 
Published: June 2022

Abstract
Background
Aneurysm treatment during cerebral vasospasm (CVS) phase is frequently considered as particularly dangerous, mainly because of the risk of cerebral infarct.

Objective
We aimed to evaluate the risk of aneurysmal subarachnoid haemorrhage (aSAH)-specific complications and functional outcome in patients treated during CVS phase.

Methods
We retrospectively analysed a large, retro- and prospectively collected database of aSAH patients admitted to our department between March 2006 and March 2020. We conducted a uni- and multivariable logistic regression analysis to evaluate influencing factors on rebleeding, cerebral infarct, Glasgow Outcome Score (GOS) at discharge and mortality and assessed the rate of angiographic vasospasm on admission.

Results
We included 853 patients. The majority of patients were female (66.6%), mean age was 57.3 years. Out of 853 included patients, 92 (10.8%) were treated during CVS phase, 312 (36.6%) underwent clipping and 541 (63.4%) endovascular treatment. Treatment during CVS phase was significantly associated with cerebral infarct in the multivariable logistic regression analysis, unrelated to the nature of intervention (OR 2.42, 1.29–4.54 95% CI p-value = 0.006). However, patients treated during CVS phase did not have increased risk of unfavourable outcome by GOS on discharge. In addition, they did not have a higher rate of rebleeding or mortality.

Conclusions
Treatment during CVS phase was significantly associated with a higher rate of cerebral infarct as confirmed by imaging. This did not reflect on GOS on discharge, rebleeding, or mortality. Aneurysm treatment during CVS phase is relatively safe and should not be postponed due to the risk of rebleeding and subsequent devastating deterioration.
Two cases of EBV infection preceding lymphoma
Authors: Saal Jonas , Aboudan Busher , Brossart Peter , Heine Annkristin 
Published: June 2022

AbstractInfection of lymphocytes with the Epstein-Barr virus (EBV) is a well-documented risk factor for developing lymphoma. The incidence of EBV positivity in lymphoma depends on the subtype and can range from 10% in diffuse large B-cell lymphoma (DLBCL) to 100% in endemic Burkitt lymphoma (BL), (Shannon-Lowe and Rickinson, Front Oncol 9:713, 2019). However, in most cases, EBV infection remains unnoticed until diagnosis of lymphoma is made. EBV seropositivity is present in > 90% of the world’s population. Although mostly asymptomatic, in some cases, EBV can cause clinical symptoms, the most common of which are fever, lymphadenopathy and pharyngitis in infectious mononucleosis. Less common presentations include lymphomatoid granulomatosis and mucocutaneous ulcer. Here we report two cases of patients, who were initially diagnosed with localized EBV infection and reactive B-cell proliferation. After B-cell-directed treatment, both patients developed overt lymphoma, in one case classical Hodgkin’s lymphoma (cHL) and in the other case angioimmunoblastic T-cell lymphoma (AITL).
Enteric glia: extent, cohesion, axonal contacts, membrane separations and mitochondria in Auerbach’s ganglia of guinea pigs
Authors: Gabella Giorgio 
Published: June 2022

Abstract
Studied by electron microscopy and morphometry, Auerbach’s ganglia comprise nerve cell bodies that occupy ~ 40% of volume; of the neuropil, little over 30% is neural processes (axons, dendrites) and little less than 30% is glia (cell bodies, processes). The amount of surface membrane of neural elements only marginally exceeds that of glia. Glial cells extend laminar processes radially between axons, reaching the ganglion’s surface with specialized membrane domains. Nerve cells and glia are tightly associated, eliminating any free space in ganglia. Glia expands maximally its cell membrane with a minimum of cytoplasm, contacting a maximal number of axons, which, with their near-circular profile, have minimal surface for a given volume. Shape of glia is moulded by the neural elements (predominantly concave the first, predominantly convex the second); the glia extends its processes to maximize contact with neural elements. Yet, a majority of axons is not reached by glia and only few are wrapped by it. Despite the large number of cells, the glia is not sufficiently developed to wrap around or just contact many of the neural elements. Mitochondria are markedly fewer in glia than in neurons, indicating a lower metabolic rate. Compactness of ganglia, their near-circular profile, absence of spaces between elements and ability to withstand extensive deformation suggest strong adhesion between the cellular elements, holding them together and keeping them at a fixed distance. Many axonal varicosities, with vesicles and membrane densities, abut on non-specialized areas of glia, suggesting the possibility of neurotransmitters being released outside synaptic sites.
Neuro-semantic prediction of user decisions to contribute content to online social networks
Authors: Cleveland Pablo , Rios Sebastian A. , Aguilera Felipe , Graña Manuel 
Published: June 2022

AbstractUnderstanding at microscopic level the generation of contents in an online social network (OSN) is highly desirable for an improved management of the OSN and the prevention of undesirable phenomena, such as online harassment. Content generation, i.e., the decision to post a contributed content in the OSN, can be modeled by neurophysiological approaches on the basis of unbiased semantic analysis of the contents already published in the OSN. This paper proposes a neuro-semantic model composed of (1) an extended leaky competing accumulator (ELCA) as the neural architecture implementing the user concurrent decision process to generate content in a conversation thread of a virtual community of practice, and (2) a semantic modeling based on the topic analysis carried out by a latent Dirichlet allocation (LDA) of both users and conversation threads. We use the similarity between the user and thread semantic representations to built up the model of the interest of the user in the thread contents as the stimulus to contribute content in the thread. The semantic interest of users in discussion threads are the external inputs for the ELCA, i.e., the external value assigned to each choice.. We demonstrate the approach on a dataset extracted from a real life web forum devoted to fans of tinkering with musical instruments and related devices. The neuro-semantic model achieves high performance predicting the content posting decisions (average F score 0.61) improving greatly over well known machine learning approaches, namely random forest and support vector machines (average F scores 0.19 and 0.21).
Boundary regularity estimates in Hölder spaces with variable exponent
Authors: Vita Stefano 
Published: June 2022

AbstractWe present a general blow-up technique to obtain local regularity estimates for solutions, and their derivatives, of second order elliptic equations in divergence form in Hölder spaces with variable exponent. The procedure allows to extend the estimates up to a portion of the boundary where Dirichlet or Neumann boundary conditions are prescribed and produces a Schauder theory for partial derivatives of solutions of any order $$k\in {\mathbb {N}}$$

k
∈
N

. The strategy relies on the construction of a class of suitable regularizing problems and an approximation argument. The given data of the problem are taken in Hölder and Lebesgue spaces, both with variable exponent.
Abnormalities of the oculomotor function in type 1 diabetes and diabetic neuropathy
Authors: D’Addio Francesca , Pastore Ida , Loretelli Cristian , Valderrama-Vasquez Alessandro , Usuelli Vera , Assi Emma , Mameli Chiara , Macedoni Maddalena , Maestroni Anna , Rossi Antonio , Lunati Maria Elena , Morpurgo Paola Silvia , Gandolfi Alessandra , Montefusco Laura , Bolla Andrea Mario , Ben Nasr Moufida , Di Maggio Stefania , Melzi Lisa , Staurenghi Giovanni , Secchi Antonio , Bianchi Marzoli Stefania , Zuccotti Gianvincenzo , Fiorina Paolo 
Published: June 2022

AbstractAimsAbnormalities in the oculomotor system may represent an early sign of diabetic neuropathy and are currently poorly studied. We designed an eye-tracking-based test to evaluate oculomotor function in patients with type 1 diabetes.MethodsWe used theSRLab—Tobii TX300 Eye tracker®, an eye-tracking device, coupled with software that we developed to test abnormalities in the oculomotor system. The software consists of a series of eye-tracking tasks divided into 4 classes of parameters (Resistance, Wideness, Pursuit and Velocity) to evaluate both smooth and saccadic movement in different directions. We analyzed the oculomotor system in 34 healthy volunteers and in 34 patients with long-standing type 1 diabetes.ResultsAmong the 474 parameters analyzed with the eye-tracking-based system, 11% were significantly altered in patients with type 1 diabetes (p < 0.05), with a higher proportion of abnormalities observed in the Wideness (24%) and Resistance (10%) parameters. Patients with type 1 diabetes without diabetic neuropathy showed more frequently anomalous measurements in the Resistance class (p = 0.02). The classes of Velocity and Pursuit were less frequently altered in patients with type 1 diabetes as compared to healthy subjects, with anomalous measurements mainly observed in patients with diabetic neuropathy.ConclusionsAbnormalities in oculomotor system function can be detected in patients with type 1 diabetes using a novel eye-tracking-based test. A larger cohort study may further determine thresholds of normality and validate whether eye-tracking can be used to non-invasively characterize early signs of diabetic neuropathy.Trial:NCT04608890.
Quality of life among young people in Norway during the COVID-19 pandemic. A longitudinal study
Authors: Lehmann Stine , Haug Ellen , Bjørknes Ragnhild , Mjeldheim Sandal Gro , T. Fadnes Lars , Skogen Jens Christoffer 
Published: June 2022

AbstractIn this study, we aimed to examine health-related quality of life during the COVID-19 pandemic among a general sample of young people in Norway aged 11–19 years. More specifically, we examine: (1) Change over 2 time-points in five health-related quality of life dimensions, (2) Whether sociodemographic- and COVID-19-related factors contributed to change in these five dimensions, (3) Whether parental stress and socioeconomic status at T1 interacted with change in health-related quality of life across T1 and T2. Data collection lasted from April 27th to May 11th, 2020 (T1), and from December 16th, 2020, to January 10th, 2021 (T2). Youth aged 11–19 years (N = 2997) completed the KIDSCREEN-27, COVID-19 related and sociodemographic items. Parents (N = 744) of youth aged 15 years and younger completed the parental stress scale and sociodemographic items. Physical and psychological wellbeing declined significantly from March to December 2020. Subscale scores for social support and peers increased. Controlling for a broad number of sociodemographic and COVID-19-related factors did not make an overall impact on the estimates. Those worried about infection, older aged, girls, and youth born outside Norway had a steeper decline in health-related quality of life subdimensions from T1 to T2. In the wake of the COVID-19 pandemic, we warrant special attention to the recovery of youth's physical and psychological wellbeing.
Fluid Mechanics of Fetal Left Ventricle During Aortic Stenosis with Evolving Hypoplastic Left Heart Syndrome
Authors: Wong Hong Shen , Wiputra Hadi , Tulzer Andreas , Tulzer Gerald , Yap Choon Hwai 
Published: June 2022

Abstract
In cases of fetal aortic stenosis and evolving Hypoplastic Left Heart Syndrome (feHLHS), aortic stenosis is associated with specific abnormalities such as retrograde or bidirectional systolic transverse arch flow. Many cases progressed to hypoplastic left heart syndrome (HLHS) malformation at birth, but fetal aortic valvuloplasty can prevent the progression in many cases. Since both disease and intervention involve drastic changes to the biomechanical environment, in-vivo biomechanics likely play a role in inducing and preventing disease progression. However, the fluid mechanics of feHLHS is not well-characterized. Here, we conduct patient-specific echocardiography-based flow simulations of normal and feHLHS left ventricles (LV), to understand the essential fluid dynamics distinction between the two cohorts. We found high variability across feHLHS cases, but also the following unifying features. Firstly, feHLHS diastole mitral inflow was in the form of a narrowed and fast jet that impinged onto the apical region, rather than a wide and gentle inflow in normal LVs. This was likely due to a malformed mitral valve with impaired opening dynamics. This altered inflow caused elevated vorticity dynamics and wall shear stresses (WSS) and reduced oscillatory shear index at the apical zone rather than mid-ventricle. Secondly, feHLHS LV also featured elevated systolic and diastolic energy losses, intraventricular pressure gradients, and vortex formation numbers, suggesting energy inefficiency of flow and additional burden on the LV. Thirdly, feHLHS LV had poor blood turnover, suggesting a hypoxic environment, which could be associated with endocardial fibroelastosis that is often observed in these patients.
A Novel Hybrid Approach for Predicting Western Australia’s Seasonal Rainfall Variability
Authors: Islam Farhana , Imteaz Monzur Alam 
Published: June 2022

AbstractIn this paper, 100 years of uninterrupted rainfall data for 12 rainfall stations (four rainfall stations from each region) in Western Australia were analyzed against respective dominant climate indices, and representative prediction models were developed using ARIMAX, GEP, and a hybrid technique (GEP-ARIMAX). Statistical performance evaluators such as Pearson correlation $$(r)$$

(
r
)

, root mean square error $$(RMSE)$$

(
R
M
S
E
)

, mean absolute error ($$MAE$$

MAE

), and refined Willmot index of agreement ($${d}_{r}$$

d
r

) were used to evaluate the prediction performance of the developed models. These models demonstrated their capability to predict up to four months in advance with Pearson correlation $$(r)$$

(
r
)

values ranging from 0.53 to 0.83, 0.75 to 0.85, and 0.87 to 0.95 for ARIMAX, GEP, and hybrid (GEP-ARIMAX) models respectively. While compared, the hybrid (GEP-ARIMAX) model showed superior prediction performance in both calibration and validation periods with Pearson correlation $$(r)$$

(
r
)

and refined Willmot index of agreement ($${d}_{r}$$

d
r

) values were as high as 0.96 and 0.84 respectively. This paper demonstrated a novel hybrid GEP-ARIMAX model showing significantly good rainfall forecasting capability than conventional linear and non-linear models.
Discriminative Bayesian filtering lends momentum to the stochastic Newton method for minimizing log-convex functions
Authors: Burkhart Michael C. 
Published: June 2022

AbstractTo minimize the average of a set of log-convex functions, the stochastic Newton method iteratively updates its estimate using subsampled versions of the full objective’s gradient and Hessian. We contextualize this optimization problem as sequential Bayesian inference on a latent state-space model with a discriminatively-specified observation process. Applying Bayesian filtering then yields a novel optimization algorithm that considers the entire history of gradients and Hessians when forming an update. We establish matrix-based conditions under which the effect of older observations diminishes over time, in a manner analogous to Polyak’s heavy ball momentum. We illustrate various aspects of our approach with an example and review other relevant innovations for the stochastic Newton method.
Zwischen interaktiver Anstrengung und rechtlichem Schutzgut – Koordinaten eines soziologischen Würdekonzeptes
Authors: Wöhrle Patrick 
Published: June 2022

ZusammenfassungSowohl die öffentlichen wie die akademischen Auseinandersetzungen um Gehalt und Bedeutung der Menschenwürde werden bis heute von der Philosophie, den Rechtswissenschaften und der Theologie dominiert; Stimmen aus der Soziologie werden hierzu nur vereinzelt vernommen. Der Beitrag verfolgt zunächst das Ziel, unter Rückgriff auf ‚würdesensible‘ klassische Autoren Koordinaten eines genuin soziologischen Würdekonzepts zu entwickeln, das Probleme des menschlichen Ausdrucks und gesellschaftsstrukturelle Faktoren (u. a. städtische Öffentlichkeit, Arbeitsteilung, Rollenvielfalt) in strenger Weise zusammendenkt. Im ersten Kapitel (1) wird daher insbesondere auf Helmuth Plessners Grenzen der Gemeinschaft und Erving Goffmans Interaktionssoziologie Bezug genommen, um in einem eher induktiven, phänomenzentrierten Zugriff überhaupt erst diejenigen Situationen und die zugehörigen gesellschaftlichen Randbedingungen zu identifizieren, in denen das Problem der Würde in einem soziologisch distinkten Sinne akut wird. Das anschließende Kapitel (2) verfolgt mit Georg Simmel, Émile Durkheim und Niklas Luhmann zunächst eine rollentheoretische Präzisierung des Würdekonzeptes, die sich vor allem an der problematischen Annahme Peter L. Bergers abarbeitet, dass die vermeintlich bruchlose Ablösung von traditionellen Ehrvorstellungen durch den Würdekomplex gleichbedeutend wäre mit einer Bedeutungsminderung gesellschaftlicher Rollenerwartungen. Das letzte Kapitel (3) hält den systematischen Ertrag der vorangegangenen Überlegungen fest und widmet sich abschließend der Frage, in welchem Verhältnis dieser Ertrag zu dem normativ emphatischen Verständnis von Menschenwürde steht, wie es dem in Philosophie und Verfassungsrecht nach wie vor dominanten Unverlierbarkeitspostulat zugrunde liegt.