bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Komunikasi Organisasi terhadap Kepuasan Kerja pada PT. Finance Multi Abadi di Jakarta
Authors: Marimin Marimin , Sunarsi Denok 
Published: January 2022

Penelitian ini bertujuan untuk mengetahui pengaruh komunikasi organisasi terhadap kepuasan kerja pada PT. Finance Multi Abadi di Jakarta. Metode yang digunakan adalah explanatory research dengan sampel sebanyak 56 responden. Teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis. Hasil penelitian ini variabel komunikasi organisasi diperoleh nilai rata-rata skor sebesar 3,737 dengan kriteria baik. Variabel kepuasan kerja diperoleh nilai rata-rata skor sebesar 3,837 dengan kriteria baik. Komunikasi organisasi berpengaruh positif dan signifikan terhadap kepuasan kerja dengan nilai persamaan regresi Y = 15,069 + 0,624X, dan nilai koefisien korelasi 0,723 atau memiliki tingkat hubungan yang kuat dengan nilai determinasi 52,3%. Uji hipotesis diperoleh signifikansi 0,000 < 0,05.
Sozialverwaltungsrecht für die Soziale Arbeit
Authors: Patjens Rainer , Patjens Tina 
Published: January 2022

Das Studienbuch richtet sich an Studierende der Sozialen Arbeit mit dem Ziel, die Klausur im allgemeinen Sozialverwaltungsrecht erfolgreich zu bewältigen. Die nunmehr 3. Auflage geht auf alle wesentliche Gesetzesänderungen ein, wie beispielsweise das Gesetz zur Stärkung von Kindern und Jugendlichen (Kinder- und Jugendstärkungsgesetz – KJSG). Dabei wurde auch weiterhin an dem bewährten Aufbau festgehalten: So gibt es in jedem Kapitel einen ersten erläuternden Teil, in dem die Inhalte dargestellt werden, und einen zweiten praktischen Teil, der den Lernerfolg anhand von Fragen und Fällen überprüft als auch das Wissen vertieft.
Multilayer Optical Waveguides as Isolators, Polarizers and Other Optical Devices: A Review
Authors: Sharma Neha 
Published: January 2022

An optical waveguide is a structure guiding the wave of light, limiting it to travel through the given and specific path. If the size of transverse dimensions is bigger than the guided light wavelength, then total internal reflection (TIR) and geometrical optics can be used to explain the working principle of geometrical optics. There is a strong control from Photonic Band Gap (PBG) structures over light and some of the best use cases of such structures rely on the functionalities while using defects in lattice which had led to the Photonic Crystal (PhC) heterostructure design. The photonic band structure is influenced by the defects in the PhC and it can cause the confinement or flow of light apart from specific pathways in the property and crystal of those structures.
In this paper, we have investigated the application areas of polarizers, isolators and other optical devices in optical waveguides. The loss occurred in the added layer and changes in the properties of the waveguide is also discussed. It is also observed that resonant layer effect (RLE) can improve and play a pivotal role to develop a lot of devices like polarizers, modulators, and isolators.
A Brief Study on Diabetes Mellitus: Pathophysiology and Diagnosis
Authors: Verma Harsh , Chakole Swarupa , Laishram Guddi 
Published: January 2022

Background: This article reviews published articles and existing diagnostic and therapeutic techniques relevant to adolescents with obesity and diabetes mellitus.
Obesity, in addition to DIABETES MELLITUS, is a crucial risk factor for the occurrence of future chronic and noncommunicable diseases.
Obese and overweight teenagers are more prone to acquire Adult Onset Diabetes, formerly rare among the younger population. However, a global trend of Adult Onset Diabetes was noted in the late 1990s and early 2000s. In the United States and the United Kingdom, and other developing and developed countries, this is particularly true. Adult Onset Diabetes is nearly as common as Insulin Dependent Diabetes in some locations. There has been a significant surge in the prevalence and severity of obesity in several population groups in teenagers.
Objective and Methodology: To read and review the existing literature on the prevalence of Diabetes Mellitus and obesity in adolescence. About 15 articles and literature were studied using the PubMed and Google Scholar search engine to produce a detailed review article on the topic of interest so chosen.
Results and Conclusion: After reviewing the articles, we can agree that TYPE-2 DIABETES MELLITUS is linked easily to young adults who are obese, that is, having a Body Mass Index of more than 30 or more than 30. TYPE-2 DIABETES MELLITUS causes destruction of receptors for insulin which results in an increased level of glucose, causing various diseases. Obesity in young adults is a critical factor in the occurrence of Adult Onset Diabetes which makes them at risk of developing severe diseases in the 3rd or 4th decade of life.
Satisfaction Levels of Remote Healthcare Simulation amongst EMS Professionals in Pune, India
Authors: Rishipathak Parag , Bhandari Monesh , Hinduja Anand 
Published: January 2022

Aim: Healthcare education comprises of various components including theory, practicals, clinical and cognitive skills. The teaching andragogy has evolved from classroom sessions and laboratory experiments to clinical rotation duties. Simulation has played a significant role as a new revolutionary tool in andragogy as it involves self-reflective and immersive learning. The COVID-19 pandemic and social distancing rules necessitated the suspension of all in-person learning activities at workplaces, public places and all educational institutes. Consequently, distance learning became essential. As a result, the classroom sessions were replaced by online mode sessions and the teaching faculties had no option but to adapt to the new technology in a short period of time. It is crucial to gauge the satisfaction levels amongst Emergency Medical Professionals (EMP’s) attending remote simulation sessions to devise more user friendly programs for the future. The aim of the study is to assess the satisfaction level of the Emergency Medical Professionals exposed to remote simulation
Study Design: Quantitative Study.
Place and Duration of Study: Symbiosis Centre for Health Skills, Pune in October 2021.
Materials and Methods: A quantitative study on satisfaction level was conducted in October 2021, amongst 200 Emergency Medical Professionals (EMP’s) in the city of Pune, India. Simulated Clinical Experiences (SCE’s) on various cardiac emergencies were designed by Simulation Educators. The participants attended the session via virtual platform Microsoft Teams for a period of 2 hours. A 19-item student satisfaction survey, was used to determine the participant’s satisfaction with the remote simulation session.
Results and Discussion: The study was conducted with the aim to adjudge the level of satisfaction amongst EMS professionals with the remote simulation mode of teaching. In the post Covid era, remote learning has become a norm and cannot be ignored. The session successfully recreated a real patient care setting and the participants enjoyed the immersive learning experience. Although limited number of participants could actively engage in the patient care during the session, the debriefing ensured that all participants were involved in the session.
Conclusion: The unanimity in the satisfaction scores is very encouraging for facilitators to devise interesting SCE’s and teach in the remote simulation mode. This shall ensure that the continued medical education does not suffer as a result of the pandemic.
Impact of COVID-19 on the Management of Diabetic Retinopathy
Authors: Gupta Pranav , Shinde Pranaykumar , Kher Praveena 
Published: January 2022

Diabetic retinopathy (DR) is one of the most common causes of vision loss in people across the world. COVID- Despite the fact that early diagnosis and management guidelines for DR have considerably lowered burden of disease, 19 disease outbreak limitations have had an impact on actual world clinical management in the care of DR patients. This research includes the most latest treatment guidelines and outcomes for DR in the context of the outbreak.
When contrasted to equivalent instants of time in 2019, intravitreal doses for DR have declined dramatically globally during the outbreak, spanning from around 30 percent to around 100percent reduction. After a substantial amount of time, several research on operational findings demonstrate a loss in visual acuity.
In the treatment of DR, changing practice methods have led to lower intravitreal doses and cumulative loss of vision acuity during follow-up. It will be vital to continue reviewing practise guidelines as more COVID mutations arise.
Relationship between Shukra Sara Purusha with Quality of Semen: A Pilot Study
Authors: Sunil P. Nikhate , Vaidehi P. Raole , Shruti Karemore 
Published: January 2022

Dhatu sarata is an excellent state for any particular dhatu (tissue). Shukra dhatu (Reproductive tissue) is one of the seven dhatu reflects reproductive health. Garbhotpadan (reproduction) is main function of Shukra dhatu (Reproductive tissue). Characteristics future of shukra (Semen) is given by ayurvedacharya and this quality of shukra (Semen) said to be best for fertility. Shukta dhatu (Semen) can be correlated with semen. Its quality and quantity affects reproduction and any deformity is lead to infertility in male. Pilot study was conducted to find out relationship between Shukta dhatu sarata and quality of semen. An observational pilot study conducted on apparently healthy volunteers. 30 male volunteers of age group 25-35 yearr were selected and their Shukra dhatu sarata (Supreme quality of Reproductive tissue) were assessed with standard proforma. Then categorized into Uttam (supreme), Madhayama (Moderate) & Hina (Average) sara on the basis of presence number of characteristics. Semen analysis i.e. semen volume, total sperm count, sperm motility is done in laboratory of same individuals. Higher Sperm count, good Sperm motility and high semen volume are found in Uttam Shukradhatusara (Supreme quality of Reproductive tissue) individuals as compare to hina shukradhatusara (Average quality of Reproductive tissue) individuals. It is not possible to come to any conclusion as this was pilot study. Further study should be conducted on large sample size.
Comparative Evaluation of Efficacy of Mannitol and Hypertonic Saline (3%) for Treatment of Moderate to Severe Traumatic Brain Injury (TBI)
Authors: Katariya Sakshi , Iratwar Sandeep 
Published: January 2022

Background: Intracranial Pressure of higher than 20 mm of Hg is considered Intracranial Hypertension. For years, Mannitol has been the go-to drug for its cure. However, it has many adverse eﬀects. Therefore, other drugs are being considered for reducing Intracranial Pressure (ICP), and hypertonic saline (HTS) appears to be a good alternative.
Methods: The reason for this study is to report any differences in results after using of mannitol or hypertonic saline for treating Intracranial Hypertension (IH) in patients who were in the tertiary care hospital to be treated of moderate or severe Traumatic Brain Injury (TBI).
Methodology: All patients who had moderate or severe Traumatic Brain Injury (TBI) i.e, were reported at the hospital and had Glasgow Coma Score lesser than 13, were admitted in the hospital over the course of 2 months of the study will be included. Patients will be randomized into 2 statistically comparable groups. Group A and Group B will be given the standard amount of mannitol and hypertonic saline (3%) and clinical result will be noted for both cases.
Results: The results will be calculated by rate of improvement in Glasgow Coma Score (GCS) of both groups and then compared. Primary endpoint will be clinical improvement after 7 days.
Conclusion: The rationale behind which drug of the two - mannitol or hypertonic saline solution (HS) - for treatment of people suffering Traumatic Brain Injury (TBI) to be primary varies considerably and there seems to be no protocol to determine which of these should be preferred. Most of the studies that have been done on the topic conclude that Hypertonic saline (HTS) seems to better suited for lowering Intracranial Pressure (ICP), regardless of its concentration. However, other than its apparent superiority in ICP reduction, it doesn’t seem to have any additional benefits, in relation to mortality.
Progress in Nanotechnology for Treating Ocular Surface Chemical Injuries: Reflecting on Advances in Ophthalmology
Authors: Qi Qiaoran , Su Dai , Zhuang Shuqin , Yao Sunyuan , Heindl Ludwig M. , Fan Xianqun , Lin Ming , Li Jin , Pang Yan 
Published: January 2025

AbstractOcular surface chemical injuries often result in permanent visual impairment and necessitate complex, long‐term treatments. Immediate and extensive irrigation serves as the first‐line intervention, followed by various therapeutic protocols applied throughout different stages of the condition. To optimize outcomes, conventional regimens increasingly incorporate biological agents and surgical techniques. In recent years, nanotechnology has made significant strides, revolutionizing the management of ocular surface chemical injuries by enabling sustained drug release, enhancing treatment efficacy, and minimizing side effects. This review provides a comprehensive analysis of the etiology, epidemiology, classification, and conventional therapies for ocular chemical burns, with a special focus on nanotechnology‐based drug delivery systems in managing ocular surface chemical injuries. Twelve categories of nanocarrier platforms are examined, including liposomes, nanoemulsions, nanomicelles, nanowafers, nanostructured lipid carriers, nanoparticles, hydrogels, dendrimers, nanocomplexes, nanofibers, nanozymes, and nanocomposite materials, highlighting their advantages in targeted delivery, biocompatibility, and improved healing efficacy. Additionally, current challenges and limitations in the field are discussed and the future potential of nanotechnology in treating ocular diseases is explored. This review presents the most extensive examination of this topic to date, aiming to link recent advancements with broader therapeutic strategies.
ZAR1/2‐Regulated Epigenetic Modifications are Essential for Age‐Associated Oocyte Quality Maintenance and Zygotic Activation
Authors: Rong Yan , Wu Yu‐Ke , Chen Yingyan , Liu Qing , Ai Leilei , Wu Yun‐Wen , Zhu Yezhang , Zhang Yin‐Li , Liu Chengkan , Ma Yerong , Tong Xiaomei , Jin Jiamin , Li Xiaoxuan , Zhou Yan , Ji Shu‐Yan , Zhang Songying , Fan Heng‐Yu 
Published: January 2025

AbstractThe developmental competence and epigenetic progression of oocytes gradually become dysregulated with increasing maternal age. However, the mechanisms underlying age‐related epigenetic regulation in oocytes remain poorly understood. Zygote arrest proteins 1 and 2 (ZAR1/2) are two maternal factors with partially redundant roles in maintaining oocyte quality, mainly known by regulating mRNA stability. In addition to this known function, it is found that ZAR1/2 is required for oocyte epigenetic maturation and zygotic reprogramming. Zar1/2‐deleted oocytes exhibited reduced levels of multiple histone modifications and of the expression of corresponding histone modifiers, along with over‐condensed chromatin, leading to compromised minor zygotic genome activation and deficient embryo development following fertilization. Cytoplasmic ZAR1/2 participated in intranuclear epigenetic maturation by binding the transcripts encoding histone modifiers and regulating their stability and translational activity. Moreover, oocytes from aged mice exhibited similar histone‐modification deficiencies as the Zar1/2‐deleted oocytes. ZAR1/2 mRNA and protein levels are downregulated in oocytes from mice and women with advanced ages, suggesting ZAR1/2 as regulators of epigenetic changes with reproductive aging. This study presents a new nucleo‐cytoplasmic interaction mechanism that is involved in preventing oocyte epigenetic aging. Further, ZAR1/2 represents potential gene targets for diagnosis and clinical interventions in age‐associated deficiencies in oocyte and embryo development.
Enhanced Genome Editing Activity with Novel Chimeric ScCas9 Variants in Rice
Authors: Liang Zhen , Wu Yuqing , Deng Shuke , Wei Sha , Zhang Kai , Guo Yingjie 
Published: January 2025

AbstractThe Streptococcus canis Cas9 protein (ScCas9) recognizes the NNG protospacer adjacent motif (PAM), offering a wider range of targets than that offered by the commonly used S. pyogenes Cas9 protein (SpCas9). However, both ScCas9 and its evolved Sc++ variant still exhibit low genome editing efficiency in plants, particularly at the less preferred NTG and NCG PAM targets. In this study, a chimeric SpcRN++ variant is engineered by grafting the recognition (REC) domain of SpCas9 into the Sc++ variant, incorporating the R221K/N394K mutations, and retaining the positively charged loop of S. anginosus Cas9. The SpcRN++ variant exhibits a higher genome editing capacity and wider target range than the Sc++ variant in rice protoplasts and stable transgenic plants. Further evidence indicates that nSpcRN++‐based A3A/Y130F and TadA8e exhibit enhanced cytosine and adenine editing efficiency in plants. Finally, herbicide‐resistant rice germplasms are produced by targeting the OsACC gene using nSpcRN++‐based adenine base editors. These results demonstrate that SpcRN++ is a powerful tool for genome editing in plants, and this integrative protein engineering strategy holds promise for engineering other Cas9 proteins.
Weighted Echo State Graph Neural Networks Based on Robust and Epitaxial Film Memristors
Authors: Guo Zhenqiang , Duan Guojun , Zhang Yinxing , Sun Yong , Zhang Weifeng , Li Xiaohan , Shi Haowan , Li Pengfei , Zhao Zhen , Xu Jikang , Yang Biao , Faraj Yousef , Yan Xiaobing 
Published: January 2025

AbstractHardware system customized toward the demands of graph neural network learning would promote efficiency and strong temporal processing for graph‐structured data. However, most amorphous/polycrystalline oxides‐based memristors commonly have unstable conductance regulation due to random growth of conductive filaments. And graph neural networks based on robust and epitaxial film memristors can especially improve energy efficiency due to their high endurance and ultra‐low power consumption. Here, robust and epitaxial Gd: HfO2‐based film memristors are reported and construct a weighted echo state graph neural network (WESGNN). Benefiting from the optimized epitaxial films, the high switching speed (20 ns), low energy consumption (2.07 fJ), multi‐value storage (4 bits), and high endurance (109) outperform most memristors. Notably, thanks to the appropriately dispersed conductance distribution (standard deviation = 7.68 nS), the WESGNN finely regulates the relative weights of input nodes and recursive matrix to realize state‐of‐the‐art performance using the MUTAG and COLLAB datasets for graph classification tasks. Overall, robust and epitaxial film memristors offer nanoscale scalability, high reliability, and low energy consumption, making them energy‐efficient hardware solutions for graph learning applications.
Hydrogen Sulfide Promotes TAM‐M1 Polarization through Activating IRE‐1α Pathway via GRP78 S‐Sulfhydrylation to against Breast Cancer
Authors: Ju Mingyi , Tong Weiwei , Bi Jia , Zeng Xianxin , Qi Aoshuang , Sun Mingli , Wen Jian , Zhao Lin , Wei Minjie 
Published: January 2025

AbstractHydrogen sulfide (H2S)‐mediated protein S‐sulfhydration has been shown to play critical roles in several diseases. Tumor‐associated macrophages (TAMs) are the predominant population of immune cells present within solid tumor tissues, and they function to restrict antitumor immunity. However, no previous study has investigated the role of protein S‐sulfhydration in TAM reprogramming in breast cancer (BC). Therefore, the aim is to investigate whether protein S‐sulfhydration can regulate TAM reprogramming and its underlying mechanism in BC. The results showed that in BC, the CTH‐H2S axis is positively correlated with the presence of an anti‐tumor phenotype in TAMs. NaHS, as an H2S donor, repolarized TAMs into M1 macrophages to block the tumor‐promoting activities of TAMs both in vitro and in vivo. Mechanistically, H2S‐mediated S‐sulfhydration of the protein chaperone glucose‐regulated‐protein 78 (GRP78) induced endoplasmic reticulum transmembrane protein kinase‐1α (IRE‐1α) dissociation from GRP78, which enhanced the phosphatase activity of IRE‐1α itself in BC‐TAMs, while the Cys420 site mutation of GRP78 interfered with these effects. Collectively, GRP78 S‐sulfhydrylation mediated by H2S at the Cys420 residue decreased the tumor burden and inhibited lung metastasis of BC through reprograming TAMs via activating the IRE‐1α pathway, indicating that targeting GRP78 S‐sulfhydration represents a promising intervention for TAM‐M1 repolarization in BC.
Structural Analysis of Plasma‐Induced Oxidation and Electric Field Effect on the Heat Shock Protein (Hsp60) Structure: A Computational Viewpoint
Authors: Attri Pankaj , Okumura Takamasa , Koga Kazunori , Shiratani Masaharu 
Published: January 2025

ABSTRACTIn recent years, there has been an increase in the study of the mechanisms behind plasma oncology. For this, many wet lab experiments and computational studies were conducted. Computational studies give an advantage in examining protein structures that are costly to extract in enough amounts to analyze the biophysical properties following plasma treatment. Therefore, in this work, we studied the effect of plasma oxidation and electric field on the human mitochondrial heat shock protein (mHsp60). Hsp60, alias chaperonin, is one of the most conserved proteins expressed across all species. Hence, we performed molecular dynamic simulations to calculate the root‐mean‐square deviation, root‐mean‐square fluctuation, and solvent‐accessible surface area of mHsp60 with and without oxidation. In addition to the oxidation state, we also applied an electric field (0.003 and 2.0 V/nm) to check the changes in the mHsp60 protein. Through simulations, we observed that the electric field strongly affects the structure of mHsp60 protein compared with the oxidation. The combination of oxidation and electric field effect increases the destabilization of the mHsp60 structure compared with their respective control states.