bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of cardiorespiratory fitness and exercise with brain white matter in healthy adults: A systematic review and meta-analysis
Authors: Maleki Suzan , Hendrikse Joshua , Chye Yann , Caeyenberghs Karen , Coxon James P. , Oldham Stuart , Suo Chao , Yücel Murat 
Published: June 2022

AbstractMagnetic resonance imaging (MRI) studies have revealed positive associations between brain structure and physical activity, cardiorespiratory fitness, and exercise (referred to here as PACE). While a considerable body of research has investigated the effects of PACE on grey matter, much less is known about effects on white matter (WM). Hence, we conducted a systematic review of peer-reviewed literature published prior to 5th July 2021 using online databases (PubMed and Scopus) and PRISMA guidelines to synthesise what is currently known about the relationship between PACE and WM in healthy adults. A total of 60 studies met inclusion criteria and were included in the review. Heterogeneity across studies was calculated using Qochran’s q test, and publication bias was assessed for each meta-analysis using Begg and Mazumdar rank correlation test. A meta-regression was also conducted to explore factors contributing to any observed heterogeneity. Overall, we observed evidence of positive associations between PACE and global WM volume (effect size (Hedges’s g) = 0.137, p < 0.001), global WM anomalies (effect size = 0.182, p < 0.001), and local microstructure integrity (i.e., corpus callosum: effect size = 0.345, p < 0.001, and anterior limb of internal capsule: effect size = 0.198, p < 0.001). These findings suggest that higher levels of PACE are associated with improved global WM volume and local integrity. We appraise the quality of evidence, and discuss the implications of these findings for the preservation of WM across the lifespan. We conclude by providing recommendations for future research in order to advance our understanding of the specific PACE parameters and neurobiological mechanisms underlying these effects.
What have we learned so far from the sex/gender issue in heart failure? An overview of current evidence
Authors: Arcopinto Michele , Valente Valeria , Giardino Federica , Marra Alberto Maria , Cittadini Antonio 
Published: June 2022

AbstractThere are important differences in epidemiology, pathophysiology, HF patterns, prognosis, and treatment. Women have a higher incidence of HFpEF due to sex-specific factors (such as anthropometry, role of estrogens, pregnancy-related cardiomyopathies), increased incidence of comorbidities, and gender-specific conditions. Men instead present a predisposition to the development of HFrEF due to a higher incidence of coronary artery disease and myocardial infarction. However, there are still gaps in the management of women with HF. The poor inclusion of women in clinical trials may have contributed to a lesser understanding of disease behavior than in men. In addition, a full understanding of gender-specific factors that are studied in small populations is lacking in the literature, and only in recent years, studies have increased their focus on this issue. Understanding how society, family, and environment affect the prognosis of HF patients may help clinicians provide more appropriate levels of care. In this overview, we aimed at summarizing all the key available evidence regarding sex/gender differences in heart failure.
Perceptions of Research Integrity Climate in Hungarian Universities: Results from A Survey among Academic Researchers
Authors: Armond Anna Catharina Vieira , Kakuk Péter 
Published: June 2022

AbstractResearch integrity climate is an important factor that influences an individual’s behavior. A strong research integrity culture can lead to better research practices and responsible conduct of research (RCR). Therefore, investigations on organizational climate can be a valuable tool to identify the strengths and weaknesses of each group and develop targeted initiatives. This study aims to assess the perceptions on integrity climate in three universities in Hungary. A cross-sectional study was conducted with PhD students, postdocs, and professors from three Hungarian universities. The survey included demographic questions, such as gender, age, scientific field, academic rank, and the Survey of Organizational Research Climate (SOURCE). A total of 432 participants completed the survey. Our results show that postdocs and assistant professors perceived integrity climate more negatively than PhD students and full professors in every survey scale. Contrarily, PhD students perceive more positively than the other groups. Disciplinary differences show that researchers in the Biomedical sciences perceive regulatory bodies to be fairer when evaluating their projects than those in the Natural sciences. Natural sciences also perceive more negatively how the department values integrity when compared to Humanities. Humanities perceive more positively Advisor/Advisee Relations than Biomedical Sciences. Our results suggest that institutions should pay more attention to early career researchers, especially insecure and temporary positions like postdocs and assistant professors. They should provide RCR resources, socialize them in RCR, and set more reasonable expectations. Moreover, department leaders should develop initiatives to foster better integrity climates.
Does Long-Term Air Pollution Exposure Affect Self-Reported Health and Limiting Long Term Illness Disproportionately for Ethnic Minorities in the UK? A Census-Based Individual Level Analysis
Authors: Al Ahad Mary Abed , Demšar Urška , Sullivan Frank , Kulu Hill 
Published: June 2022

Abstract
Previous studies have investigated the impact of air pollution on health and mortality. However, there is little research on how this impact varies by individuals’ ethnicity. Using a sample of more than 2.5-million individuals aged 16 and older from the 2011 UK census linked to 10-years air pollution data, this article investigates the effect of air pollution on self-reported general health and limiting long-term illness (LLTI) in five main ethnic groups and by country of birth in UK. The association of air pollution with self-reported health and LLTI by individual’s ethnicity was examined using two levels mixed-effects generalised-linear models. Pakistani/Bangladeshi, Indian, Black/African/Caribbean, and other ethnic minorities and people born outside UK/Ireland were more likely to report poorer health and the presence of LLTI than White-group and UK/Ireland born individuals. Higher concentrations of NO2, SO2 and CO pollutants were associated with poorer self-reported health and the presence of LLTI in the UK population. Analysis by ethnicity showed a more pronounced effect of NO2, PM10, PM2.5, and CO air pollution on poor self-reported health and the presence of LLTI among ethnic minorities, mostly for people from Black/African/Caribbean origin compared to White people, and among non-UK/Ireland born individuals compared to natives. Using a large-scale individual-level census data linked to air pollution spatial data, our study supports the long-term deteriorating effect of air pollution on self-reported health and LLTI, which is more pronounced for ethnic minorities and non-natives.
A hybrid fuzzy-AHP-TOPSIS model for evaluation of manufacturing relocation decisions
Authors: Sequeira Movin , Adlemo Anders , Hilletofth Per 
Published: June 2022

Abstract
Manufacturing relocation decisions are complex because they involve combinations of location modes like offshoring or reshoring, and governance modes like insourcing or outsourcing. Furthermore, the uncertainty involved in the decision-making process makes it challenging to reach a right-shoring decision. This study presents a hybrid fuzzy-AHP-TOPSIS model to support generic relocation decisions. Industry experts were involved in a pairwise comparison of the competitive priorities’ decision criteria. A meta-synthesis of empirical studies is used to generate theoretical relocation scenarios. The presented hybrid model is used to rank the relocation scenarios in order to identify the most pertinent alternative. The resiliency of the solution is presented through a sensitivity analysis. The results indicate that the proposed hybrid model can simultaneously handle all the main relocation options involving governance modes. Based on the input data in this study, the competitive priorities criteria quality, time and cost are shown to have a strong impact, whereas the sustainability criterion has a weak impact on the choice of relocation option. The research presented in this paper contributes to the research field of manufacturing relocation by demonstrating the suitability of the hybrid fuzzy-AHP-TOPSIS model for relocation decisions and the resilience of the results. Furthermore, the research contributes to practice by providing managers with a generic relocation decision-support model that is capable of simultaneously handling and evaluating various relocation alternatives.
Diagnosis, treatment, and prevention of severe acute hepatitis of unknown etiology in children
Authors: Chen Ying-Hu , Lou Jin-Gan , Yang Zi-Hao , Chen Qing-Jiang , Hua Chun-Zhen , Ye Sheng , Zhang Chen-Mei , Chen Jie , Huang Zong-Wei , Yu Jin-Dan , Gao Zhi-Gang , Shu Qiang 
Published: June 2022

Abstract
Background
Severe acute hepatitis of unknown etiology in children has recently exhibited a global trend of concentrated occurrence. This review aimed to summarize the current available information regarding the outbreak of severe acute hepatitis and introduce our hospital’s previous experiences with the diagnosis and treatment of severe acute hepatitis for reference.

Data sources
Websites including the UK Health Security Agency, European Centre for Disease Prevention and Control, CDC, WHO, and databases including PubMed/Medline, Cochrane Library, Embase and Web of Science were searched for articles on severe acute hepatitis in children.

Results
As of May 26, 2022, a total of 650 cases have been reported in 33 countries; at least 38 (6%) children required liver transplantation, and nine (1%) died. Cases are predominantly aged between 3 and 5 years old, and there are no epidemiological links among them. The common manifestations are jaundice, vomiting and pale stools. Adenovirus tested positive in most cases, and SARS-CoV-2 and other viruses were detected in a few cases, but virus particles were not found in liver tissue. Adenovirus immunohistochemistry showed immunoreactivity in the intrasinusoidal lumen from some liver samples. The hierarchical treatment includes symptomatic and supportive therapy, management of coagulation disorders and hepatic encephalopathy, artificial liver support, and liver transplantation (approximately 6%–10% of cases require liver transplant).

Conclusions
The etiology of this severe acute hepatitis in children is not clear. The clinical features are severe acute hepatitis with significantly elevated liver enzymes. Clinicians need to be alert to children with hepatitis.
Identification of hub genes predicting the development of prostate cancer from benign prostate hyperplasia and analyzing their clinical value in prostate cancer by bioinformatic analysis
Authors: Chen Xi , Ma Junjie , Xu Chengdang , Wang Licheng , Yao Yicong , Wang Xinan , Zi Tong , Bian Cuidong , Wu Denglong , Wu Gang 
Published: June 2022

AbstractProstate cancer (PCa) and benign prostate hyperplasia (BPH) are commonly encountered diseases in males. Studies showed that genetic factors are responsible for the occurrences of both diseases. However, the genetic association between them is still unclear. Gene Expression Omnibus (GEO) database can help determine the differentially expressed genes (DEGs) between BPH and PCa. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were utilized to find pathways DEGs enriched. The STRING database can provide a protein–protein interaction (PPI) network, and find hub genes in PPI network. R software was used to analyze the clinical value of hub genes in PCa. Finally, the function of these hub genes was tested in different databases, clinical samples, and PCa cells. Fifteen up-regulated and forty-five down-regulated genes were found from GEO database. Seven hub genes were found in PPI network. The expression and clinical value of hub genes were analyzed by The Cancer Genome Atlas (TCGA) data. Except CXCR4, all hub genes expressed differently between tumor and normal samples. Exclude CXCR4, other hub genes have diagnostic value in predicting PCa and their mutations can cause PCa. The expression of CSRP1, MYL9 and SNAI2 changed in different tumor stage. CSRP1 and MYH11 could affect disease-free survival (DFS). Same results reflected in different databases. The expression and function of MYC, MYL9, and SNAI2, were validated in clinical samples and PCa cells. In conclusion, seven hub genes among sixty DEGs may be achievable targets for predicting which BPH patients may later develop PCa and they can influence the progression of PCa.
Prioritizing risk genes as novel stratification biomarkers for acute monocytic leukemia by integrative analysis
Authors: He Hang , Wang Zhiqin , Yu Hanzhi , Zhang Guorong , Wen Yuchen , Cai Zhigang 
Published: June 2022

AbstractAcute myeloid leukemia (AML) is a blood cancer with high heterogeneity and stratified as M0–M7 subtypes in the French-American-British (FAB) diagnosis system. Improved diagnosis with leverage of key molecular inputs will assist precisive medicine. Through deep-analyzing the transcriptomic data and mutations of AML, we report that a modern clustering algorithm, t-distributed Stochastic Neighbor Embedding (t-SNE), successfully demarcates M2, M3 and M5 territories while M4 bias to M5 and M0 & M1 bias to M2, consistent with the traditional FAB classification. Combining with mutation profiles, the results show that top recurrent AML mutations were unbiasedly allocated into M2 and M5 territories, indicating the t-SNE instructed transcriptomic stratification profoundly outperforms mutation profiling in the FAB system. Further functional data mining prioritizes several myeloid-specific genes as potential regulators of AML progression and treatment by Venetoclax, a BCL2 inhibitor. Among them two encode membrane proteins, LILRB4 and LRRC25, which could be utilized as cell surface biomarkers for monocytic AML or for innovative immuno-therapy candidates in future. In summary, our deep functional data-mining analysis warrants several unappreciated immune signaling-encoding genes as novel diagnostic biomarkers and potential therapeutic targets.
Was the European oil industry prepared for the current global crisis?
Authors: Ionescu Romeo Victor , Zlati Monica Laura , Antohi Valentin Marian , Stanciu Silvius 
Published: June 2022

AbstractThe paper focuses on the impact of the complex global crisis on the European oil industry. The main objective of the research is to define, implement and validate a model able to quantify the developments and risks faced by this industry at European level. In order to achieve this objective, dynamic statistical analysis takes into account specific indicators of production, demand and actual consumption over a significant period of time. Special attention is given to the impact of the pandemic on this industry. The analysis takes into consideration the latest official statistical data and is connected to the most important global trends in the oil industry. The main result of this scientific approach is the building of a pertinent instrument/model able to assist the decision-makers in calibrating the European oil industry to global market requirements and developments. By using this tool, key elements of energy policy can be identified that can bring valuable clarifications in the context of the industry's new orientations towards green energy and the reduction of polluting fuels.
Synergistic mechanism of well pattern adjustment and heterogeneous phase combined flooding on enhancing oil recovery in mature fault-block reservoirs
Authors: He Hong , Liu Wenzheng , Chen Yuqiu , Liu Huan , Liu Haocheng , Luo Guangjie 
Published: June 2022

AbstractWith the maturity of fault-block reservoirs, the water percolation channels are formed after long-term waterflooding, which leads to large amounts remaining oil unrecovered and low recovery efficiency. Thus, it is imperative to seek for enhancing oil recovery methods to improve the development performance of mature fault-block reservoirs. Well pattern adjustment and heterogeneous phase combined flooding are both feasible technologies for enhancing oil recovery in mature fault-block reservoirs. Nevertheless, both technologies have their limitations. Thus, a hybrid approach combining WPA and HPCF was proposed. In this study, the large-scale plate sand-pack model flooding experiments were conducted to investigate whether hybrid strategy has better EOR ability than the single WPA or HPCF. Thereafter, on the basis of incremental oil recovery and distribution of remaining oil, the mechanism of the synergistic effect of WPA and HPCF was illustrated. Finally, the influence of reservoir inclination on development performance was proposed. The results show that EOR of hybrid strategy is the highest, followed by single HPCF, and single WPA is the least. The HPCF mainly recovers remaining oil on both sides of main streamline after water flooding, and it prolongs the period of EOR validity. WPA can change the fluid flow direction and force the subsequent liquid enters the un-swept non-main streamline areas in the water flooding stage. Furthermore, by combining WPA and HPCF, the HPCF can enter the non-main streamline areas to expand sweep volume and improve oil displacement efficiency under the induction of WPA. Besides, the reservoir inclination has an obvious influence on the development performance of fault-block reservoir. With the increase of reservoir inclination, the incremental oil recovery of the single strategy or hybrid strategy decreases. Thus, these findings of this study can help for better understanding the synergetic effect of HPCF and WPA, which can provide a hybrid strategy for enhancing oil recovery in mature fault-block reservoir.
Getting personal with collaborative sustainability experimentation: Reflections and recommendations from a transdisciplinary partnership with the Swedish craft beer sector
Authors: Ness Barry , Wahl Darin 
Published: June 2022

AbstractThis paper provides reflections on transdisciplinary knowledge coproduction and experimentation processes from sustainability researcher perspectives. It centers on a 5-year period of collaborative research with small- and medium-sized enterprises in an Urban Living Lab in the Swedish craft beer sector. Nine reflections cover a variety of issues and potentials encountered during numerous interactions with societal partners, and are structured by three levels: organizational, interpersonal and intrapersonal. Based on the reflections, authors then propose a set of seven considerations and recommendations for how to more effectively collaborate in such transdisciplinary constellations. The recommendations apply across the three levels, and describe an approach to collaborative research that asks the researcher to be open, transparent, self-aware and intentional, reflective and reflexive, and both adaptive and flexible. Furthermore, they aim to create soft structures to facilitate understanding and mutual learning, such as designating “organizational champions”, as well as to embed collaborative reflections into recurring meetings with partners to maintain trust and capture sustainability knock-on opportunities as they arise.
Joy, anger, and anxiety during the teaching practicum: how are these emotions related to dimensions of pre-service teachers’ self-efficacy?
Authors: Bach Andreas , Hagenauer Gerda 
Published: June 2022

AbstractAccording to research relating to the sources of teacher self-efficacy, the relationship between emotions and self-efficacy beliefs has primarily been studied with a focus on negative emotions. Additionally, studies have utilized scales that only distinguish between positive and negative affect and do not allow for differentiation between emotions. Furthermore, the significance of distinct emotions has been inadequately addressed, although more detailed knowledge is needed to better understand the formation of self-efficacy beliefs. Based on a sample of pre-service teachers during their teaching practicum at an Austrian university and with the use of latent regression models, we examined the relationship between three concrete emotions (joy, anger, anxiety) and self-efficacy beliefs related to instructional strategies, classroom management, and student engagement. Findings indicated different associations: joy was positively associated with self-efficacy beliefs in all domains, while anger was negatively related to self-efficacy beliefs for student engagement. Anxiety was found to be negatively related to self-efficacy beliefs for classroom management and, in particular, instructional strategies. In conclusion, the results demonstrate significant relationships between both negative and positive emotions and pre-service teachers’ self-efficacy beliefs in the practicum.
Palaeogeographic significance of rugose corals: El Guadiato Area (Southwestern Spain) as a case study
Authors: Rodríguez-Castro Isabel , Rodríguez Sergio 
Published: June 2022

AbstractCarboniferous rugose corals are useful for palaeoecological, palaeoenvironmental and palaeogeographic studies. However, most analyses are qualitative and/or comprise corals from long stratigraphical intervals, and detailed palaeogeographic studies in the Carboniferous from western Palaeotethys are scarce. This report presents a quantitative analysis of the late Visean coral assemblages from the El Guadiato Area (Southwestern Spain), which has been thoroughly studied during the last 30 years. This case study aims to check the utility of rugose corals in detailed palaeogeographic studies, reconstructing tectonic movements in the suture zone between the Ossa Morena and Centroiberian domains in the Iberian Massif. Sixty-one rugose coral species from the El Guadiato Area were included in the analyses. Moreover, two other late Visean rugose coral faunas have been added as an external reference: Los Santos de Maimona (Southwestern Spain) and Kingscourt (Ireland). The presence/absence datasets have been treated with paired group (UPGMA) Hierarchical Clustering and a Detrended Correspondence Analysis. The results of this study support previous observations about the palaeogeography of the El Guadiato Area, backing the hypothesis that the strike slip faults of the area produced large lateral displacements. The results of analyses conducted at this level of detail appear to be conditioned by palaeoenvironmental differences, but the results of the comparison with Los Santos de Maimona and with Kingscourt’s faunas look promising for future larger comparisons between different basins.