bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of taro paste on physicochemical properties and nutritional components of bran pork sausage
Authors: Kryzhska Tanya , Shang Fei Fei 
Published: November 2022

The research of adding plant materials to sausage is more popular. Taro paste is the plant raw material obtained by mashing taro after cooking. It contains rich small granules of starch, dietary fiber, and sweetened drinks are widely added. The natural flavor and the quality of glutinous taro paste are its unique characteristics. In this study, different proportions of taro paste were added to the pork sausage containing bran instead of starch, and the substitution amount was 0 %, 20 %, 40 %, 60 %, 80 %, and 100 % respectively. It is expected to improve the tissue structure, sensory quality, and nutritional composition of the sausage. This study analyzed cooking loss, emulsion stability, color, texture characteristics, moisture, sensory changes, and nutrient composition. The results showed that compared with the control group, the cooking loss, water loss and fat loss decreased significantly, and the brightness (L * value) of sausage increases, the yellowness (b * value) shows an unsTable fluctuation of decreasing and increasing, and the redness (a * value) has no obvious change; The hardness and viscosity of the sausages were significantly reduced, but the elasticity and resilience were not significantly altered; The relaxation time is shortened, and the internal semi bound moisture content is increased; Sensory evaluation results showed that all treatment groups achieved the best scores in terms of overall accepTable levels, especially for sausages with taro instead of 40 % starch; Protein, ash, water content and pH also gradually increased, while fat content decreased. By comprehensive comparison, the quality of the sausages is best when the amount of taro paste is 40 %
A conceptual model of the data ecosystem formation in the health 4.0
Authors: Mammadovа Masuma , Ahmadova Aytan Adil 
Published: November 2022

Digitalization of health and medicine has become a global trend in recent years. The development of this trend is manifested in improving the quality of medical care, increasing access to medical services, and ensuring more effective health decisions. The global health trend is characterized by the transition from e-health to digital health, which is closely related to the formation and development of Industry 4.0. The projection of innovative approaches of Industry 4.0 into the health sector opens up great opportunities for creating a new healthcare paradigm (Health 4.0) by integrating modern technologies, analytical tools and smart medical devices.
This article highlights Industry 4.0 technologies, the integration of which into healthcare has led to the generation of a huge amount of various data. Data collected through new technologies on the Health 4.0 platform, their types, structure, sources and capabilities are examined. It is shown that for the collection, transmission, storage, processing of heterogeneous data of a large volume, the introduction of new approaches and methods is required. In the environment of technological transformation, the evolution of the healthcare system at the data level and the conceptual model of the chain of formation of the Healthcare 4.0 ecosystem are proposed. The content of the components included in the Healthcare 4.0 data ecosystem is determined. Some problems arising in the formation of the data ecosystem on the Healthcare 4.0 platform and the processing of large health data are studied
Scanning electron microscopy and X-ray microanalysis of the condition of concrete structures of a chemical enterprise with long-term corrosion in a sulfate environment
Authors: Ivchenko Viktoriia , Shkromada Oksana , Shvets Olha 
Published: November 2022

Long-term operation of premises in aggressive environments of chemical enterprises affects the surfaces of concrete structures and leads to the formation of destructive processes.
The aim of the study was to determine changes in the structure and mineral composition of concrete during long-term operation in an aggressive sulfate environment at a chemical plant for the production of titanium dioxide using the sulfate method to predict the service life of concrete structures.
It has been established that during the production of TiO2 pigment by the sulfate method, the ore is decomposed by sulfate acid at high temperature, accompanied by the release of H2SO4 vapor, sulfur dioxide SO2, hydrogen sulfide H2S and elemental sulfur. Studies have established that sulfate corrosion leads to the formation of sulfur and iron oxides on the concrete surface. Studies have revealed vast areas of the surface covered with crystals of elemental sulfur, the contents of which are confirmed by the results of X-ray microanalysis. The sizes of sulfur crystals in the image range from 12 to 180 µm, the shape corresponds to the rhombic allotropic modification S8. The penetration depth of iron sulfates into the thickness of concrete is about 50 microns. The microstructure of the surface is loose, with signs of corrosion.
Exposure to a high concentration of sulphate acid vapors in the workshop of the enterprise led to the destruction of calcium carbonate and the formation of gypsum crystals in concrete. The formation of gypsum crystalline hydrates provokes sulfate corrosion of concrete, resulting in the formation of pores and microcracks in concrete with the formation of calcium hydrosulfoaluminate.
The studies carried out using scanning electron microscopy and X-ray microanalysis make it possible to investigate the structural changes and mineral composition of concrete under the influence of long-term sulfate corrosion.
Sufistic Approach in Understanding Hadith: Ḥakīm al-Tirmidhī’s Viewpoint
Authors: Arafat Ahmad Tajuddin , Mutma'inah Mutma'inah , Rosyida Hanik 
Published: November 2022

This article studies al-Ḥakīm al-Tirmidhī’s viewpoints toward understanding hadith on his work “Nawādir al-Uṣūl fi Ma’rifat Aḥādīth al-Rasūl.” Using the content analysis approach, this study reveals that the primary purpose of transmitting hadith is that the hadith’s message is supposed to be practiced so that happiness in the hereafter can be achieved, not just transmitting hadith from one person to another without any practical implication. So, it not only orients on the chain of transmission but also profoundly understands the matan or its contents. He quotes some hadith in his works to expose the meaning and the essence contained in every hadith and hopes that it can be a guideline of sulūk for those who intend to get closer (taqarrub) to God. Hence, the Sufism viewpoint becomes his basic epistemology in understanding the hadith.Contribution: This article provides a new perspective of the hadith transmitter requirement according to al-Tirmidhī, namely, having a critical view towards everything that is heard and accepted. It also shows that understanding hadith is not just to reveal its meaning but a sulūk for those who want to get closer to Allah.
Adaptive and Compensatory Mechanisms of the Cardiovascular System and
Disease Risk Factors in Young Males and Females
Authors: Abdullah Marzoog Basheer 
Published: November 2022

Background:
Cardiovascular disease (CVD) is increasing dramatically in young people and is the leading cause of death worldwide.

Aims:
This study aimed to evaluate differences in the adaptive and compensatory mechanisms of the cardiovascular system (CVS) in young men and women to determine the most significant risk factors and assess the stability of the non-invasive method used in the early detection of CVD risk factors in young people.

Objectives:
Currently, early evaluation of CVD risk factors is possible only through invasive methods, such as the Framingham risk score and the SCORE chart. Therefore, the development of a more flexible and non-invasive method is crucial in large populations.

Methods:
A cohort cross-sectional investigation examined 173 volunteers, divided into two groups according to gender (n1 female=83, n2 male=90), and their heart rate, blood pressure (SBP/DBP), height, weight, and waist and hip circumference were non-invasively measured. Then, the potential adaptation value (R.M. Baevsky et al., 1987), Martinet test (MT), body mass index (BMI), and waist/hip ratio were calculated. Moreover, we collected information on lifestyle risk factors, including tobacco smoking, alcohol consumption, factors related to unhealthy diet, lack of physical activity, sleep deprivation, and anxiety, through special in-person interviews using paper/online questionnaires. The T-test and the x2 tests were applied for statistical analysis.

Results:
Impaired/pathological cardiovascular adaptation was observed in 11.54% of the female group and 46.07% of the male group. In the female group, cardiovascular recovery abnormalities were observed in the SBP, DBP, and HR MT in 20.59%, 16.18%, and 44.12%, respectively, whereas in the male group, 32.50%, 21.25% and 36.25%, respectively. Despite gender, these deviations were accompanied by the prevalence of sympathetic influences in the regulation of CVS functions in 72.73% of the first group and 69.66% of the second group. BMI was violated in 47.19% of males and 29.49% of females. The test results were identical to that in the invasive methods of assessment of CVD risk factors.

Conclusion:
Abnormalities in cardiovascular adaptation mechanisms in young women are less pronounced. Gender-dependent risk factors have high yields, such as obesity, low physical activity, and hypertension, which are more pronounced in men. The usability of the test requires further investigation on a larger sample.
Recent Advances in Biological Active Sulfonamide based Hybrid
Compounds Part C: Multicomponent Sulfonamide Hybrids
Authors: Ghomashi Reihane , Ghomashi Shakila , Aghaei Hamidreza , Massah Samineh , Massah Ahmad Reza 
Published: November 2022

Abstract:
Sulfonamides, with the general formula R-SO2NR1R2, have attracted great attention
since the early discovery of sulfonamide-containing antibacterial drugs. The combinations
of certain sulfonamides and other drug molecules to form sulfonamide hybrids
are being used to develop novel formulations with greater effectiveness and in a huge
range of therapeutic applications such as antimicrobial, antifungal, anti-inflammatory, antitubercular,
antiviral, antidiabetic, antiproliferative, carbonic anhydrase inhibitor, antimalarial,
anticancer and other medicinal agents. Part C of this review presents recent advances
in designing and developing multicomponent sulfonamide hybrids containing more
than one biologically active heterocycle, such as coumarin, indole, pyridine, pyrimidine,
pyrazole, triazole, oxazole, oxadiazole, triazine, quinazoline, and thiadiazol. This review
aims to highlight the status of the hybridization technique in synthesizing biological and
computational studies of novel sulfonamide hybrids that were designed and presented between
2016 and 2020.
Reduction of Electron-Rich Nitro Heteroarenes; A Comprehensive Review
Authors: Vengatesh Gopal , Nanjan Pandurangan 
Published: November 2022

Abstract:
Amino heterocycles are important in drug design due to their unique intrinsic and
physicochemical properties. Though these molecules look simple, their selective reduction is
challenging because of their rich electron density in the ring. Additionally, reducing nitro
groups in heterocycles is crucial in designing different materials. With this in view, several
reduction methods have been developed and applied to various heterocyclic compounds.
However, there is no dedicated report on these special types of compounds. With careful
analysis, the studies are systematically summarized from conventional methods to advance
materials based on their catalytic activity, durability, recyclability, and stability. Further, detailed
insights are discussed to motivate chemists working in catalysts.
Maternally Expressed Gene 3 Negatively Regulated Decorin to
Supresse Angiogenesis, Proliferation and Migration of Endothelial
Cells
Authors: Dai Dongwei , Zhang Lei , Li Jin , Di Yunhai , Tian Chun‘ou , Liu Jianmin , Hong Bo 
Published: November 2022

Background:
Angiogenesis of tumor cells is highly associated with tumor-secreted factors and matrix proteins. However, the underlying mechanism of tumor-secreted factors and matrix proteins during angiogenesis is rarely discussed.

Objectives:
This study investigated the relationship between the maternally expressed gene 3 (MEG3), a tumor-secreted growth factor, and Decorin, a tumor-secreted matrix protein, and evaluated their derivate roles in human endothelial cell development.

Methods:
Human endothelial cells were transiently transfected with a plasmid expressing antisense of Decorin mRNA (shDecorin) and silencing mRNA of MEG3 (siMEG3) or MEG3 over-expressive vectors. A series of qPCR and Western blot analysis was applied to characterize the expressions of MEG3 and Decorin in all transfected cells. Moreover, scratch, Transwell, and Matrigel neovascularization assays were performed to examine three key processes of endothelial cells' angiogenesis, including tubulogenesis, proliferation, and migratory levels. In addition, the cell viability was evaluated at each step via the MTT test.

Results:
The overexpression of MEG3 inhibited angiogenesis and migration of endothelial cells by preventing the expression of Decorin. At the same time, the inhibition of MEG3 via siRNA resulted in an increased expression of Decorin, enhanced tube formation levels, and promoted endothelial cell proliferation and migration. Furthermore, Decorin's knockdown suppressed the angiogenesis and migration of endothelial cells without affecting the expression of MEG3. Importantly, the stimulation of HUVEC cells with exogenous Decorin protein alleviated most phenotypes induced by the upregulation of MEG3.

Conclusion:
Our study demonstrated the anti-growth effects of MEG3 on vasculogenesis and migration of endothelial cells. Thus, by blocking the expression of Decorin in HUVECs, the overexpression of MEG3 repressed their development and might potentially alleviate the ischemic stroke.
Children and Adolescents with Irritable Bowel Syndrome: Treatment and
Management
Authors: Wal Ankita , Wal Pranay , Verma Neha , Pandey Shiv Shanker , Krishnan Karthickeyan , Bhowmick Mithun 
Published: November 2022

Background:
Irritable bowel syndrome (IBS) is a disorder that causes stomach pain in children and adolescents. It may also impact one's quality of life. IBS is linked to gastrointestinal issues such as diarrhoea and constipation. Despite the identification of several potential pathophysi-ological pathways, the aetiology of IBS remained unknown

Objective:
The aim of this paper is to discuss the diagnosis, pathogenesis, case studies and treatment of Irritable bowel syndrome in children and adolescents.

Methods:
This systematic review covered relevant papers from the previous ten years that were accessible in Science Direct, Elsevier, NCBI, and Web of Science related to the pathophysiology and function of pharmacological drugs such as antidepressants, antispasmodics, prokinetics, and antibiotics in children with irritable bowel syndrome.

Results:
those have been demonstrated to be effective. This article presents case studies including 50-59 children, which demonstrate a favourable acceptable impact that is more effective than a pla-cebo in terms of reducing symptoms and improving the overall quality of life in children who have irritable bowel syndrome. Furthermore, the majority of the pathophysiological explanations and treatment options discussed are based on adult studies. These major issues arose when treating paediatric IBS, and they must be addressed in order to properly treat children with IBS. Trials that focus on many combinations of pharmacological and non-pharmacological therapies seem to be more helpful.

Discussion:
In recent years, a number of systematic reviews have been conducted to evaluate the efficacy of medication treatments in children for IBS; however, the dependability of these systemat-ic reviews needs to be further investigated owing to the various experimental designs and levels of evidence used. This article highlights paediatric therapy options, including pharmaceutical medica-tions such as antidepressants, antispasmodics, prokinetics, and antibiotics. The goal is to alleviate IBS symptoms while also enhancing the quality of life for children with this illness.
The effects of Tyrosine Kinase Inhibitors (TKIs) in monotherapy and with add-on treatments on Health-related Quality of Life of People with Chronic Myeloid Leukemia: a systematic review of Randomized-Controlled Trials.
Authors: Nardi Antonio E , Sancassiani Federica , Barrui Vanessa , Kalcev Goce , Uras Veronica , Meloni Giulia , Marongiu Luigi , Tamburini Giorgio , Maleci Alberto , Quagliato Laiana A , La Nasa Giorgio , Carta Mauro Giovanni 
Published: November 2022

Background:
The era of establishing tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML) changed the outcome and the course of this life-threatening malignancy. People suffering from CML have now a better prognosis and a longer life expectancy by the development of TKIs, even if it requires long term—often lifelong— treatments that are nonetheless associated with improved Health-related Quality of life (HRQoL). However, data on the effects of TKIs on HRQoL are not always systematic: sometimes they were obtained by studies different from RCTs, or without a clear definition of what HRQoL is. The main purpose of this systematic review is to summarize all randomized-controlled trials (RCTs) including HRQoL as main or secondary outcome in patients with CML treated with TKIs or with TKIs plus an add-on treatment.

Methods:
Systematic review by searching for relevant papers in PubMed/Medline and Web of Science with the following keywords: “quality of life” OR “health-related quality of life” OR “QoL” OR “HRQoL” OR “H-QoL” AND “chronic myeloid leukemia”. Interval was set from January 2000 to December 2020.

Results:
40 papers were identified through the search. Out of them, 7 RCTs were included. All the studies used standardized measures to assess HRQoL, even not always specific for CML. 5 RCTs randomized subjects to 2 or 3 arms to evaluate the effects of TKIs of the first, second and third generation in monotherapy. 2 RCTs randomized subjects to TKI therapy plus an add-on treatment versus TKI therapy as usual. The results of all these trials were examined and discussed.

Conclusion:
All the included RCTs pointed out significant findings about the positive effects of TKIs on HRQoL of people with CML, both when they were used in monotherapy or, notably, with an add-on treatment to enhance TKIs effects.
Relationship Between Procrastination and Stress Responses
Authors: Zhang Li Yang , Kato Chieko , Aoki Koichiro , Otsuka Yoshiomi 
Published: November 2022

Introduction:
Procrastination is a maladaptive behavior that leads to failure of tasks, and a decrease in self-esteem and negative emotions; this behavior, however, becomes a habit. If procrastination becomes a habit, it will have a negative impact on your body and mind. Previous studies have divided participants by gender, age, etc., and relationships between procrastination and stress have been examined. However, a general relationship between procrastination and stress has not been clarified. This study examined the relationship between procrastination and stress through a questionnaire survey.

Methods:
This study also examined the effects of passive or active procrastination on stress responses through a survey on active procrastination tendency. In addition, surveys were conducted on Japanese and Chinese people, and their answers were analyzed and compared between them. Hypotheses in this study are as follows: there are relationships between the participants’ general procrastination tendency and stress responses (Hypothesis 1); participants with higher general procrastination tendency show higher stress responses than those with higher active procrastination tendency (Hypothesis 2). There are differences in relationships between procrastination tendencies and stress responses between Japanese and Chinese participants (Hypothesis 3). The results of the analysis have been discussed based on differences in cultural and social backgrounds.

Results:
These results showed a positive correlation between general procrastination and stress response in both Japanese and Chinese populations. Active procrastination was found to be positively correlated with stress response in Japanese and negatively correlated in Chinese.

Conclusion:
The results suggest that the relationship between procrastination and stress response is influenced by the subject's cultural background.
The Use and Structure of Emergency Nurses’ Triage Narrative Data: Scoping Review
Authors: Picard Christopher , Kleib Manal , Norris Colleen , O'Rourke Hannah M , Montgomery Carmel , Douma Matthew 
Published: November 2022

Background
Emergency departments use triage to ensure that patients with the highest level of acuity receive care quickly and safely. Triage is typically a nursing process that is documented as structured and unstructured (free text) data. Free-text triage narratives have been studied for specific conditions but never reviewed in a comprehensive manner.

Objective
The objective of this paper was to identify and map the academic literature that examines triage narratives. The paper described the types of research conducted, identified gaps in the research, and determined where additional review may be warranted.

Methods
We conducted a scoping review of unstructured triage narratives. We mapped the literature, described the use of triage narrative data, examined the information available on the form and structure of narratives, highlighted similarities among publications, and identified opportunities for future research.

Results
We screened 18,074 studies published between 1990 and 2022 in CINAHL, MEDLINE, Embase, Cochrane, and ProQuest Central. We identified 0.53% (96/18,074) of studies that directly examined the use of triage nurses’ narratives. More than 12 million visits were made to 2438 emergency departments included in the review. In total, 82% (79/96) of these studies were conducted in the United States (43/96, 45%), Australia (31/96, 32%), or Canada (5/96, 5%). Triage narratives were used for research and case identification, as input variables for predictive modeling, and for quality improvement. Overall, 31% (30/96) of the studies offered a description of the triage narrative, including a list of the keywords used (27/96, 28%) or more fulsome descriptions (such as word counts, character counts, abbreviation, etc; 7/96, 7%). We found limited use of reporting guidelines (8/96, 8%).

Conclusions
The breadth of the identified studies suggests that there is widespread routine collection and research use of triage narrative data. Despite the use of triage narratives as a source of data in studies, the narratives and nurses who generate them are poorly described in the literature, and data reporting is inconsistent. Additional research is needed to describe the structure of triage narratives, determine the best use of triage narratives, and improve the consistent use of triage-specific data reporting guidelines.

International Registered Report Identifier (IRRID)
RR2-10.1136/bmjopen-2021-055132