bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: A Case of β-Ureidopropionase Deficiency Complicated With MELAS Syndrome Caused by UPB1 Variant and Mitochondrial Gene Variant
Authors: Shu Jianbo , Zhi Xiufang , Chen Jing , Lei Meifang , Zheng Jie , Sheng Wenchao , Zhang Chunhua , Li Dong , Cai Chunquan 
Published: February 2022

Backgroundβ-Ureidopropionase deficiency is a rare autosomal recessive disease affecting the last step of pyrimidine degradation. Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome is a rare inherited disorder caused by genetic defects in mitochondrial DNA.Case PresentationOne 8-year-old boy presented with dizziness, vomiting, and convulsions. The gas chromatography–mass spectrometry results suggested β-ureidopropionase deficiency. The whole-exome sequencing results revealed homozygous missense variant c.977G&gt;A (p.R326Q) in UPB1. However, the patient presented with persistent hyperlactacidemia and metabolic acidosis, which did not correspond to the classic features of β-ureidopropionase deficiency. Combined with the manifestations of developmental delay, poor academic performance, and poor sports stamina, whole-mitochondrial-genome sequencing was performed. The results exhibited the variant m.3243A&gt;G of MT-TL1 gene. The level of heterogeneity was 65% in the patient and 17.8% in his mother. Eventually, the final diagnosis of β-ureidopropionase deficiency combined with MELAS syndrome was made.ConclusionThe report about β-ureidopropionase deficiency caused by a nuclear gene variant and MELAS syndrome caused by a mitochondrial gene variant coexisting in the same patient enriches the clinical study of these two rare diseases.
How Different Are Threshold and Other Specified Feeding and Eating Disorders? Comparing Severity and Treatment Outcome
Authors: Withnell Samantha J. , Kinnear Abbigail , Masson Philip , Bodell Lindsay P. 
Published: February 2022

BackgroundOther Specified Feeding and Eating Disorders (OSFED) are characterized by less frequent symptoms or symptoms that do not meet full criteria for another eating disorder. Despite its high prevalence, limited research has examined differences in severity and treatment outcome among patients with OSFED compared to threshold EDs [Anorexia Nervosa (AN), Bulimia Nervosa (BN), and Binge Eating Disorder (BED)]. The purpose of the current study was to examine differences in clinical presentation and treatment outcome between a heterogenous group of patients with OSFED or threshold EDs.MethodPatients with threshold EDs (AN = 42, BN = 50, BED = 14) or OSFED (n = 66) presenting for eating disorder treatment completed self-report questionnaires at intake and discharge to assess eating disorder symptoms, depression symptoms, impairment, and self-esteem.ResultsAt intake, OSFED patients showed lower eating concerns compared to patients with BN, but similar levels compared to AN and BED. The OSFED group showed higher restraint symptoms compared to BED, and similar restraint to AN and BN. Global symptoms as well as shape and weight concerns were similar between OSFED and threshold ED groups. There were no differences between diagnostic groups in self-esteem, depression scores, or symptom change from intake to discharge.DiscussionOur findings suggest that individuals with OSFED showed largely similar ED psychopathology and similar decreases in symptoms across treatment as individuals diagnosed with threshold EDs. Taken together, findings challenge the idea that OSFED is less severe and more resistant to treatment than threshold EDs.
Perceived Fatality Prior to COVID-19 Infection in 13 Latin American Countries (FAT-LAT-COVID-19): Revalidation of a Shortened Scale
Authors: Mejia Christian R. , Aveiro-Róbalo Telmo Raúl , Garlisi-Torales Luciana D. , Carranza Esteban Renzo Felipe , Mamani-Benito Oscar , Vilela-Estrada Martín A. , Serna-Alarcón Víctor , Jaramillo-Aguilar Damary S. , Rojas-Roa Javiera L. 
Published: February 2022

IntroductionCOVID-19 has generated great repercussions for the population globally; millions of deaths have been reported worldwide. The idea of death is especially exacerbated when there are close to death experiences that remind us how close we are to fatality. This is why it is important to measure fatalistic ideas of those who have not yet been infected.ObjectiveTo revalidate a scale that measures fatalistic perception prior to COVID-19 infection in a population of 13 Latin American countries.MethodologyWe conducted an instrumental study. We used a previously validated scale in Peru, with seven items divided into two factors and with five possible Likert-type responses (from strongly disagree to strongly agree). It was administered to a large population in 13 Spanish-speaking countries in Latin America; for each of the seven questions, 886 people were surveyed. With these results, descriptive and analytical statistics were performed.ResultsThe mean, standard deviation, skewness, and kurtosis of the seven initial questions were adequate in most cases. In the confirmatory factor analysis, the lack of fit was improved with the indexes' modification technique, which let us delete items 1 and 6. Thus, we could obtain satisfactory goodness-of-fit indices (CFI = 0.972, TLI = 0.931, GFI = 0.990, AGFI = 0.961, RMSEA = 0.080, and RMR = 0.047). Therefore, the final two-factor structure had a fairly adequate Cronbach's α (0.72, with a 95% confidence interval = 0.70–0.73).ConclusionsThe scale that measures fatalism of Latin American countries in the face of the pandemic generated by COVID-19 was revalidated and shortened.
Characteristics of Facial Muscle Activity Intensity in Patients With Schizophrenia and Its Relationship to Negative Symptoms
Authors: Du Xia , Fan Hong Zhen , Wang Yun Hui , Zhang Jie , Zhu Xiao Lin , Zhao Yan Li , Tan Shu Ping 
Published: February 2022

IntroductionPrevious studies have shown that in addition to having impairments in facial emotion recognition, patients with schizophrenia also show a lack of facial expression. Although negative symptoms such as decreased facial activity are common symptoms of schizophrenia, the related factors remain inconclusive. Therefore, this study compared healthy controls to explore the characteristics of facial muscle activity intensity in patients with schizophrenia and its relationship with negative symptoms.MethodsThis observational and cross-sectional study conducted in a psychiatric hospital in China included a total of 135 patients with schizophrenia and 134 healthy controls. The negative symptoms of schizophrenia were evaluated using the Brief Negative Symptom Scale. The intensity of facial muscle activity under positive, neutral, and negative emotional stimuli conditions was automatically collected by a computer, including 17 values (F01-F17) that represent different facial muscle activities. Statistical tests were performed to analyze facial muscle activity indexes, to explore an objective and quantitative method to evaluate the negative symptoms of schizophrenia.ResultsThe facial muscle activity intensity of the schizophrenia group at F02 (outer eyebrow), F04 (upper eyelid), F07 (nose), F10 (dimple), F12 (lower jaw 1), F14 (lip 2), and F17 (blink) was lower than that of the healthy controls (p &lt; 0.05). Under positive, neutral, and negative emotional stimuli conditions, the facial muscle activity intensity of F16 (lower jaw 2) was positively correlated with negative symptoms (p &lt; 0.05).ConclusionOur study indicated that patients with schizophrenia show defects in facial muscle activity and that is associated with negative symptoms.
Socioeconomic Differences in Cigarette Smoking and Alternative Tobacco Product Use Among Adolescents in a School-Based Smoking Preventive Intervention: Findings From the Second Year of the X:IT II Study
Authors: Kjeld Simone Gad , Lund Lisbeth , Andersen Susan , Bast Lotus Sofie 
Published: February 2022

BackgroundHealth interventions may differently impact adolescents from diverse backgrounds. This study examined whether a smoking preventive intervention was equally effective in preventing cigarette smoking and use of alternative tobacco products (ATPs, i.e., snus, e-cigarettes, and waterpipe) among students from different socioeconomic backgrounds, i.e., occupational social classes (OSC).MethodsData was from the school-based intervention X:IT II targeting 13- to 15-year-olds Danes. The intervention focused on three main components: smoke-free school time, smoke-free curriculum, and parental involvement. In total, 46 schools were included at baseline (N = 2,307, response rate = 86.3%). Using a difference-in-differences approach, changes in current smoking and ever use of ATPs were estimated among students in high versus low OSC at second follow-up. Analyses were based on available cases (N = 826) and multiple imputations of missing data at the second follow-up (N = 1,965).ResultsAt baseline (age 13), 1.0% of students from high OSC and 4.8% from low OSC currently smoked cigarettes, while this was the case among 24.5 and 25.6%, respectively, at the second follow-up (age 15). Estimates indicated that social inequalities in current smoking diminished over time (p &lt; 0.001). Regarding ATPs, 10.0% of high OSC students and 13.9% of low OSC students had ever used ATPs at baseline, while at second follow-up, 46.8 and 60.8%, respectively, had ever used ATPs. Estimates indicated that social inequalities in ever use of ATPs widened over time (p &lt; 0.001).ConclusionsThe X:IT II intervention seemed to diminish socioeconomic disparities in smoking over the study period. Meanwhile, social inequalities in ever use of ATPs increased. Therefore, besides focusing on narrowing the social disparities in cigarette smoking, future efforts may, to a larger extent, focus on adolescents' use of ATPs.
Aging-Related Moderation of the Link Between Compliance With International Physical Activity Recommendations and the Hemodynamic, Structural, and Functional Arterial Status of 3,619 Subjects Aged 3–90 Years
Authors: Zócalo Yanina , Gómez-García Mariana , Torrado Juan , Bia Daniel 
Published: February 2022

BackgroundCompliance with physical activity recommendations (CPARs) is associated with better health indicators. However, there are only few studies to date that have comprehensively analyzed the association between CPARs and cardiovascular status “as a whole” (e.g., analyzing hemodynamic, structural, and functional properties, and different arterial territories). The relationship between CPARs and cardiovascular properties could be strongly influenced by the growth and aging process.AimThe goal of the study is to investigate the association between CPAR and cardiovascular properties by placing special emphasis on: (i) identifying if there is an independent association, (ii) if the association is “moderated” by age, and (iii) to what extent the association depends on the arterial parameter (hemodynamic vs. structural vs. functional) and/or the arterial segment (e.g., central vs. peripheral; elastic vs. transitional vs. muscular arteries).MethodsA total of 3,619 subjects (3–90 years of age) were studied. Extensive cardiovascular evaluations were performed. Cardiovascular risk factors (CRFs) and physical activity (PA) levels were determined. The subjects were categorized as compliant (n = 1, 969) or non-compliant (n = 1,650) with World Health Organization-related PA recommendations. Correlation and multiple regression models (including CPAR*Age interaction) were obtained, and Johnson-Neyman technique was used to produce regions of significance.ResultsThe independent association between CPARs and cardiovascular characteristics were strongly moderated by age. The moderation was observed on a wide range of age but particularly notorious on the extremes of life. Certain arterial characteristics demonstrated opposite effects in relation to CPAR status depending on the range of age considered. The association between CPAR and cardiovascular characteristics was independent of CRFs and moderated by age. In subjects younger than 45–55 years, CPAR status was associated with lower central and peripheral blood pressure (i.e., the younger the subject, the higher the reduction). During adult life, as age increases in the subjects, CPARs was associated with a beneficial hemodynamic profile, which is not related with variations in pressure but strongly related with lower levels of waveform-derived indexes and ventricular afterload determinants.ConclusionsThe independent associations between CPARs and arterial properties were strongly moderated by age. Data provided by blood pressure levels and waveform-derived indexes would be enough to evaluate the independent association between CPARs and the vascular system in the general population.
Recent Advance in Small Molecules Targeting RhlR of Pseudomonas aeruginosa
Authors: Lim Taehyeong , Ham So-Young , Nam SangJin , Kim Myoungsun , Lee Ki Yong , Park Hee-Deung , Byun Youngjoo 
Published: February 2022

Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic gram-negative pathogen that can cause various infections, particularly in patients with compromised host defenses. P. aeruginosa forms biofilms and produces virulence factors through quorum sensing (QS) network, resulting in resistance to antibiotics. RhlI/RhlR, one of key QS systems in P. aeruginosa, is considered an attractive target for inhibiting biofilm formation and attenuating virulence factors. Several recent studies examined small molecules targeting the RhlI/RhlR system and their in vitro and in vivo biological activities. In this review, RhlR-targeted modulators, including agonists and antagonists, are discussed with particular focus on structure-activity relationship studies and outlook for next-generation anti-biofilm agents.
Widespread Ability of Ligninolytic Fungi to Degrade Hazardous Organic Pollutants as the Basis for the Self-Purification Ability of Natural Ecosystems and for Mycoremediation Technologies
Authors: Pozdnyakova Natalia , Dubrovskaya Ekaterina , Schlosser Dietmar , Kuznetsova Svetlana , Sigida Elena , Grinev Vyacheslav , Golubev Sergei , Kryuchkova Elena , Varese Giovanna Cristina , Turkovskaya Olga 
Published: February 2022

The ability of sixteen wood- and soil-inhabiting basidiomycete strains and four ascomycete strains to degrade the most hazardous, widespread, and persistent pollutants (polycyclic aromatic hydrocarbons, oxyethylated nonylphenol, alkylphenol, anthraquinone-type synthetic dyes, and oil) was found. The disappearance of the pollutants, their main metabolites, and some adaptive properties (activities of ligninolytic enzymes, the production of emulsifying compounds and exopolysaccharides) were evaluated. The toxicity of polycyclic aromatic hydrocarbons decreased during degradation. New data were obtained regarding (1) the dependence of the completeness of polycyclic aromatic hydrocarbon degradation on the composition of the ligninolytic enzyme complex; (2) the degradation of neonol AF9-12 by higher fungi (different accessibilities of the oxyethyl chain and the aromatic ring of the molecules to different fungal genera); and (3) the production of an emulsifying agent in response to the presence in the cultivation medium of hydrophobic pollutants as the common property of wood- and soil-inhabiting basidiomycetes and ascomycetes. Promise for use in mycoremediation was shown in the wood-inhabiting basidiomycetes Pleurotus ostreatus f. Florida, Schizophyllum commune, Trametes versicolor MUT 3403, and Trametes versicolor DSM11372; the litter-decomposing basidiomycete Stropharia rugosoannulata; and the ascomycete Cladosporium herbarum. These fungi degrade a wide range of pollutants without accumulation of toxic metabolites and produce ligninolytic enzymes and emulsifying compounds.
Liouville-Type Results for a Two-Dimensional Stretching Eyring–Powell Fluid Flowing along the z-Axis
Authors: Díaz José L. , Rahman Saeed ur , Nouman Muhammad 
Published: February 2022

The purpose of this study is to establish Liouville-type results for a three-dimensional incompressible, unsteady flow described by the Eyring–Powell fluid equations. The fluid is studied in a plane Ωp while it moves along the z-axis. Therefore the main functions to analyze are given by u(x,y,z,t) and v(x,y,z,t), belonging to Ωp. The results are obtained for globally bounded initial data as well as their corresponding derivatives, and the variations in velocity along the z-axis belong to the space L2 and BMO. Under such conditions, Liouville-type results are obtained and extended to Lp, p>2.
Entre o rural e o urbano:
Authors: Fortti Eduardo Luiz 
Published: February 2022

Esse trabalho tem como objetivo entender a mistura entre o rural e o urbano no cotidiano dos moradores da cidade de São Paulo na virada do século XIX para o XX. Para compreender esse cotidiano foi necessário observar o grande crescimento populacional, entender a diversidade de origens desses novos moradores da cidade e como sobreviviam. Além de apresentar como o rural e o urbano estavam próximos no cotidiano do paulistano e de como eles se relacionavam com as áreas verdes, rios e animais tão presentes na vida dos moradores da cidade, que muitas vezes eram vistos como grandes incômodos e atraso, mas também como um meio de sobrevivência para os menos abastados.
Predicting Intrauterine Fetal Infection in Pregnant Women with Chronic Hepatitis C
Authors: Матейко Г.Б. , Матвисив М.В. 
Published: February 2022

Работа посвящена изучению факторов риска внутриутробного инфицирования плода у беременных женщин с хроническим гепатитом С на основе анализа клинико-лабораторных данных, занесенных в прогностическую карту с целью прогнозирования риска внутриутробного инфицирования плода.
The work is dedicated to the study of risk factors for intrauterine infection of the fetus in pregnant women with chronic hepatitis C based on the analysis of clinical and laboratory data entered in the prognostic chart in order to predict the risk of intrauterine infection of the fetus.
The Experience of Using Hydrogen Peroxide Vapor (VHP VICTORY, STERIS) and Wet Steam (VACUDES, BMT) for Decontamination of Protective Overalls During the SARS-CoV-2 (COVID-19) Pandemic
Authors: Алексеева М.Г. , Маджарова О.А. , Галицкая С.С. 
Published: February 2022

Представлены результаты оценки качества проведенного обеззараживания защитных костюмов, используемых для работы в красной зоне Республиканского клинического медицинского центра Управления делами Президента Республики Беларусь в период с мая по декабрь 2020 г. В качестве методов дезинфекции комбинезонов после работы с пациентами, инфицированными коронавирусом COVID-19, использовались метод дезинфекции влажным паром в дезинфекционной камере и система биологического обеззараживания помещений сухим паром перекиси водорода. Проведен анализ эффективности обеззараживания, дана оценка сохранности костюмов, а также возможности повторного использования СИЗ после дезинфекции.
The study presents the results of assessing the quality of the disinfection of protective suits used for work in the red zone of the Republican Clinical Medical Center of the Administrative Department of the President of the Republic of Belarus in the period from May to December 2020. As methods of disinfection of overalls after working with patients infected with coronavirus COVID-19, the method of disinfection with wet steam in a disinfection chamber was used, as well as a system for biological disinfection of premises with dry steam of hydrogen peroxide. The analysis of the effectiveness of disinfection was carried out, the safety of suits was assessed and the possibility of reusing PPE after disinfection was assessed.
The Role of IgA in the Diagnosis of COVID-19 Infection
Authors: Анисько Л.А. , Рогачева Т.А. , Карпов И.А. 
Published: February 2022

Иммунологические исследования широко используются в практической лабораторной медицине для диагностики инфекционных и неинфекционных заболеваний. В ряде публикаций имеются противоречивые сведения об использовании IgА для диагностики COVID-19инфекции. В данной статье приведены результаты исследований по определению IgА в сыворотке крови и носоглоточных смывах (НГС) от пациентов с коронавирусной инфекцией (КВИ).
Immunological studies are widely used in practical laboratory medicine for the diagnosis of infectious and non-infectious diseases. A number of publications contain conflicting information about the use of IgA for the diagnosis of COVID-19 infection. This article presents the results of studies on the determination of IgA in blood serum and nasopharyngeal washings from patients with coronavirus infection (CVI).
STRATEGI PENGUMPULAN DAN PENYALURAN DANA INFAK/SEDEKAH ASN PADA BADAN AMIL ZAKAT NASIONAL (BAZNAS) KAB. POLEWALI MANDAR
Authors: Busrah Busrah , Damayanti Andi 
Published: February 2022

Penelitian ini membahas tentang ”Strategi Pengumpulan dan Penyaluran dana Infak/Sedekah ASN pada Badan Amil Zakat Nasional (BAZNAS) Kab. Polewali Mandar, yang menjadi fokus penelitian penulis adalah Lembaga Badan Amil Zakat Nasional (BAZNAS) Kab. Polewali Mandar dalam mengumpulkan dan menyalurkan Dana Infak/sedekah ASN serta faktor pendukung dan penghambat dalam pengumpulan dan penyaluran dana Infak/sedekah ASN. Dalam menyusun Skripsi ini metode yang digunakan bersifat kualitatif deskriptif yaitu data yang dikumpulkan berupa kata – kata, gambar bukan angka – angka, yang terdiri dari wawancara langsung dengan struktur kepemimpinan sampai kepada staf/anggota Baznas, dokumentasi kegiatan penulis, dan studi keperpustakaan yang terkait dengan judul penulis. Hasil penelitian menunjukkan bahwa Strategi yang dilakukan Badan Amil Zakat Nasional (BAZNAS) Kab. Polewali Mandar dalam bidang pengumpulan ialah dengan menyusun RKAT yang didalamnya memuat berbagai macam cara untuk mencapai target anggaran – anggaran yang diperlukan, salah satunya dengan melakukan kerja sama dengan berbagai OPD terkait data ASN untuk pembayaran zakat profesi dan mesjid – mesjid dalam hal ini iman didagunakan untuk menampung dana zakat dari masyarakat sekaligus sebagai media informasi/motivasi agar tingkat kesadaran, ketulusan dan keikhlasan masyarakat dapat lebih meningkat. Adapun faktor pendukung yang dimiliki Baznas ialah dengan adanya adanya sumber dana tetap, yaitu Infaq/sedekah ASN, infaq haji,dan akan ditambah lagi dengan zakat profesi yang akan diberlakukan per maret 2020, ditambah lagi letak kantor Baznas yang sangat strategis. Disamping faktor pendukung ada pula faktor penghambat ialah kurangnya tingkat kesadaran masyarakat tentang hukum islam mengenai baiknya mengeluarkan zakat, infak dan sedekah, serta masih kuatnya tradisi/kebiasaan yang ada di masyarakat untuk memberi zakat secara langsung.