bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitivity and uncertainty analysis for structural health monitoring with crack propagation under random loads: A numerical framework in the frequency domain
Authors: Marques Denys , Vandepitte Dirk , Tita Volnei 
Published: October 2022

AbstractThe quantification of uncertainties in a system and the ability to identify the most influential parameters for a given structural health monitoring (SHM) strategy constitutes an important step for an in‐depth analysis of the problem. It is used in reliability assessment and for the definition of proper inspection intervals. In a recent paper, the authors proposed a methodology for SHM and fatigue life estimations of structures under random loads. This paper expands over those concepts and presents a framework for sensitivity and uncertainty analysis for SHM of structures in the frequency domain. The structure is an Euler–Bernoulli beam, which is modeled with the Ritz method. The conceptual simplicity of the Ritz model keeps the computational cost low. The results showed that the Walker parameter for the crack propagation law,
; the modal damping factor; and the input acceleration are important parameters affecting the variance of the remaining useful life.
Browning affects pelagic productivity in northern lakes by surface water warming and carbon fertilization
Authors: Puts Isolde C. , Ask Jenny , Deininger Anne , Jonsson Anders , Karlsson Jan , Bergström Ann‐Kristin 
Published: October 2022

AbstractGlobal change impacts important environmental drivers for pelagic gross primary production (GPP) in northern lakes, such as temperature, light, nutrient, and inorganic carbon availability. Separate and/or synergistic impacts of these environmental drivers on pelagic GPP remain largely unresolved. Here, we assess key drivers of pelagic GPP by combining detailed depth profiles of summer pelagic GPP with environmental and climatic data across 45 small and shallow lakes across northern Sweden (20 boreal, 6 subarctic, and 19 arctic lakes). We found that across lakes summer pelagic GPP was strongest associated with lake water temperatures, lake carbon dioxide (CO2) concentrations impacted by lake water pH, and further moderated by dissolved organic carbon (DOC) concentrations influencing light and nutrient conditions. We further used this dataset to assess the extent of additional DOC‐induced warming of epilimnia (here named internal warming), which was especially pronounced in shallow lakes (decreasing 0.96°C for every decreasing m in average lake depth) and increased with higher concentrations of DOC. Additionally, the total pools and relative proportion of dissolved inorganic carbon and DOC, further influenced pelagic GPP with drivers differing slightly among the boreal, subarctic and Arctic biomes. Our study provides novel insights in that global change affects pelagic GPP in northern lakes not only by modifying the organic carbon cycle and light and nutrient conditions, but also through modifications of inorganic carbon supply and temperature. Considering the large‐scale impacts and similarities of global warming, browning and recovery from acidification of lakes at higher latitudes throughout the northern hemisphere, these changes are likely to operate on a global scale.
The use of flyswatter game to assist elementary learners’ vocabulary learning: Gamification in TCSOL
Authors: Xiao Xue , Li Shuangling 
Published: October 2022

AbstractThis study investigates the effects of the flyswatter game on elementary students’ Chinese vocabulary learning. Using a pre‐ and post‐test design, the study examined the development by two groups of beginner learners in Laos. Both groups received the same Chinese course, with the experimental group being taught with the flyswatter game while the control with a traditional method. The results suggest that the experimental group had significantly larger improvement than the control group, especially regarding the learning of the vocabulary types “dates” and “Chinese zodiac animals.” The results also indicate that this game may be more effective for the learning of vocabulary presented in characters than in other forms like pictures. These findings provide insights into a strategic use of this game in elementary classrooms.
Validation of a rapid potency assay for cord blood stem cells using phospho flow cytometry: The IL‐3‐pSTAT5 assay
Authors: Simard Carl , Fournier Diane , Trépanier Patrick 
Published: October 2022

AbstractIntroductionPublic cord blood banks (CBBs) are required to measure cord blood units (CBUs) potency before their release, allowing for the identification of units that may be unsuitable for haematopoietic transplantation. We have developed a rapid flow cytometry assay based on the measurement of STAT‐5 phosphorylation of CD34+ stem cells in response to IL‐3 stimulation.MethodTo adapt the assay from a research setting to its implementation within our CBB regulated operations, we proceded with a full method validation and a correlation comparison of the IL‐3‐pSTAT5 assay results with the colony‐forming unit assay (CFU) results. A total of 60 CBUs cryopreserved in vials were analysed by flow cytometry to determine the sensitivity, specificity, intra‐assay precision, robustness, reproducibility, and inter‐laboratory agreement of the assay. The CFU assay was also done on the same samples for comparison purposes.ResultsThe assay threshold was established at 50% CD34+CD45+pSTAT5+, which provides a 100% sensitivity and a 98.3% specificity. An average intra‐assay CV of 7.3% was determined. All results met our qualitative results acceptance criteria regarding the inter‐user and inter‐laboratory agreements, IL‐3 stimulation time, post‐thaw incubation delay and staining time. The IL‐3‐pSTAT5 assay results correlated well with the total CFU determined using the CFU assay (r2 = 0.82, n = 56).ConclusionThis study shows that our rapid flow cytometry assay can be successfully validated and that the potency data obtained display good sensitivity, specificity and robustness. These results demonstrate the feasibility of implementing this assay within CBB operations, as a validated potency assay.
Mothering in the context of intimate partner violence: A feminist intersectional critique of the nursing literature
Authors: Broughton Sharon , Ford‐Gilboe Marilyn , Varcoe Colleen 
Published: October 2022

AbstractAimsTo describe how mothers and mothering in the context of IPV are conceptualized in the nursing research and practice literature with attention to underlying ideologies, biases and potential harms.DesignFeminist intersectionality was used as a theoretical and analytic lens.Data SourcesArticles published between 2000 and 2021 in the nursing literature, identified by searching Google Scholar, CINAHL, PubMed and Scopus databases, and conducting bibliographic reviews of published articles.Review MethodsSearch terms included: intimate partner violence, domestic violence, parenting, mother and nursing. Initial screening resulted in inclusion of 98 papers for analysis.ResultsFour dominant ways of conceptualizing mothering in the context of IPV were identified: (1) IPV is conceptualized as a discrete acute event and/or crisis, (2) mothering is treated as a practice, (3) mothers are valued as vehicles for child health and well‐being and (4) mothers are seen as vulnerable and ‘at risk’. These narrow constructions are rooted in ideologies such as normative motherhood, deficit and grit/resilience and neoliberalism. Emerging shifts in the literature are providing an important counter‐balance.ConclusionBiases in nursing knowledge about mothering in the context of IPV may limit nursing's capacity to support the health of these women and their children. The integration of emerging perspectives that emphasize strengths and equity is critical in strengthening nursing knowledge and practice and in beginning to redress existing limitations and potential harms.ImpactThis critique focused on higher‐income countries of the Global North but raises fundamental questions that should be considered in other contexts. Applying broader conceptualizations of mothers, mothering and IPV to research and practice can help improve the quality of care available.
Stream diatom biodiversity in islands and continents—A global perspective on effects of area, isolation and environment
Authors: Jamoneau Aurélien , Soininen Janne , Tison‐Rosebery Juliette , Boutry Sébastien , Budnick William R. , He Siwen , Marquié Julien , Jyrkänkallio‐Mikkola Jenny , Pajunen Virpi , Teittinen Anette , Tupola Vilja , Wang Beixin , Wang Jianjun , Blanco Saúl , Borrini Alex , Cantonati Marco , Valente Adelaide Clode , Delgado Cristina , Dörflinger Gerald , Gonçalves Vítor , Kennedy Bryan , Marques Helena , Papatheodoulou Athina , Raposeiro Pedro Miguel , Ritter Catarina , Serafim António , Van de Vijver Bart , Passy Sophia I. 
Published: October 2022

AbstractAimThe species–area relationship (SAR) is one of the most distinctive biogeographic patterns, but global comparisons of the SARs between island and mainland are lacking for microbial taxa. Here, we explore whether the form of the SAR and the drivers of species richness, including area, environmental heterogeneity, climate and physico‐chemistry, differ between islands and similarly sized areas on mainland, referred to as continental area equivalents (CAEs).LocationGlobal.TaxonStream benthic diatoms.MethodsWe generated CAEs on six continental datasets and examined the SARs of CAEs and islands (ISAR). Then, we compared CAEs and islands in terms of total richness and richness of different ecological guilds. We tested the factors contributing to richness in islands and CAEs with regressions. We used structural equation models to determine the effects of area versus environmental heterogeneity, climate and local conditions on species richness.ResultsWe found a non‐significant ISAR, but a significant positive SAR in CAEs. Richness in islands was related to productivity. Richness in CAEs was mainly dependent on area and climate, but not directly on environmental heterogeneity. Species richness within guilds exhibited inconsistent relationships with island isolation and area.Main conclusionsEcological and evolutionary processes shaping diatom island biogeography do not depend on area at the worldwide scale probably due to the presence of distinct species pool across islands. Conversely, area was an important driver of diatom richness in continents, and this effect could be attributed to dispersal. Continents had greater richness than islands, but this was a consequence of differences in environmental conditions such as specific island climatic conditions. We stress the need for more island data on benthic diatoms, particularly from archipelagos, to better understand the biogeography of this most speciose group of algae.
The role of renal nerve stimulation in percutaneous renal denervation for hypertension: A mini‐review
Authors: Huang Hui‐Chun , Cheng Hao‐min , Chia Yook‐Chin , Li Yan , Van Minh Huynh , Siddique Saulat , Sukonthasarn Apichard , Tay Jam Chin , Turana Yuda , Verma Narsingh , Kario Kazuomi , Wang Tzung‐Dau 
Published: October 2022

AbstractRecent trials have demonstrated the efficacy and safety of percutaneous renal sympathetic denervation (RDN) for blood pressure (BP)‐lowering in patients with uncontrolled hypertension. Nevertheless, major challenges exist, such as the wide variation of BP‐lowering responses following RDN (from strong response to no response) and lack of feasible and reproducible peri‐procedural predictors for patient response. Both animal and human studies have demonstrated different patterns of BP responses following renal nerve stimulation (RNS), possibly related to varied regional proportions of sympathetic and parasympathetic nerve tissues along the renal arteries. Animal studies of RNS have shown that rapid electrical stimulation of the renal arteries caused renal artery vasoconstriction and increased norepinephrine secretion with a concomitant increase in BP, and the responses were attenuated after RDN. Moreover, selective RDN at sites with strong RNS‐induced BP increases led to a more efficient BP‐lowering effect. In human, when RNS was performed before and after RDN, blunted changes in RNS‐induced BP responses were noted after RDN. The systolic BP response induced by RNS before RDN and blunted systolic BP response to RNS after RDN, at the site with maximal RNS‐induced systolic BP response before RDN, both correlated with the 24‐h ambulatory BP reductions 3–12 months following RDN. In summary, RNS‐induced BP changes, before and after RDN, could be used to assess the immediate effect of RDN and predict BP reductions months following RDN. More comprehensive, large‐scale and long term trials are needed to verify these findings.
Who should be screened for primary aldosteronism? A comprehensive review of current evidence
Authors: Huang Wei‐Chieh , Lin Yen‐Hung , Wu Vin‐Cent , Chen Chen‐Huan , Siddique Saulat , Chia Yook‐Chin , Tay Jam Chin , Sogunuru Guruprasad , Cheng Hao‐Min , Kario Kazuomi 
Published: October 2022

AbstractArterial hypertension is a major risk factor for cardiovascular disease. The prevalence of primary aldosteronism (PA) ranges from 5% to 10% in the general hypertensive population and is regarded as one of the most common causes of secondary hypertension. There are two major causes of PA: bilateral adrenal hyperplasia and aldosterone‐producing adenoma. The diagnosis of PA comprises screening, confirmatory testing, and subtype differentiation. The Endocrine Society Practice Guidelines for the diagnosis and treatment of PA recommends screening of patients at an increased risk of PA. These categories include patients with stage 2 and 3 hypertension, drug‐resistant hypertension, hypertensive with spontaneous or diuretic‐induced hypokalemia, hypertension with adrenal incidentaloma, hypertensive with a family history of early onset hypertension or cerebrovascular accident at a young age, and all hypertensive first‐degree relatives of patients with PA. Recently, several studies have linked PA with obstructive sleep apnea and atrial fibrillation unexplained by structural heart defects and/or other conditions known to cause the arrhythmia, which may be partly responsible for the higher rates of cardiovascular and cerebrovascular accidents in patients with PA. The aim of this review is to discuss which patients should be screened for PA, focusing not only on well‐established guidelines but also on additional groups of patients with a potentially higher prevalence of PA, as has been reported in recent research.
Central hypertension is a non‐negligible cardiovascular risk factor
Authors: Cheng Yi‐Bang , Li Yan , Cheng Hao‐Min , Siddique Saulat , Huynh Minh Van , Sukonthasarn Apichard , Chen Chen‐Huan , Wang Ji‐Guang 
Published: October 2022

AbstractHigh blood pressure (BP) confers cardiovascular risk. However, the clinical value of central BP remains debatable. In this article, we aim to briefly review the prognosis, diagnosis, and treatment of central hypertension. Central and brachial BPs are closely correlated. In most prospective investigations, elevated central and peripheral BPs were similarly associated with adverse outcomes. Outcome‐driven thresholds of the central systolic BP estimated by the type I device were on average 10 mmHg lower than their brachial counterparts. Cross‐classification based on the central and brachial BPs identified that nearly 10% of patients had discrepancy in their status of central and brachial hypertension. Irrespective of the brachial BP status, central hypertension was associated with increased cardiovascular risk, highlighting the importance of central BP assessment in the management of hypertensive patients. Newer antihypertensive agents, such as renin–angiotensin–aldosterone system inhibitors and calcium channel blockers, were more efficacious than older agents in central BP reduction. Clinical trials are warranted to demonstrate whether controlling central hypertension with an optimized antihypertensive drug treatment will be beneficial beyond the control of brachial hypertension.
Effectiveness of salt substitute on cardiovascular outcomes: A systematic review and meta‐analysis
Authors: Tsai Yi‐Ching , Tsao Yen‐Po , Huang Chi‐Jung , Tai Yen‐Hsuan , Su Yang‐Chin , Chiang Chern‐En , Sung Shih‐Hsien , Chen Chen‐Huan , Cheng Hao‐Min 
Published: October 2022

AbstractHypertension‐related death is the leading cause of mortality worldwide, making blood pressure (BP) control an important issue. Salt substitute is a non‐pharmaceutical strategy to improve hypertension control. The goal of this study was to evaluate the effect of salt substitute on BP and cardiovascular disease. The authors searched the Cochrane Library and PubMed databases through March 2022, and assessed the risk‐of‐bias for included studies by the Cochrane risk‐of‐bias tool. Twenty‐three randomized controlled trials with 32073 patients were included in our systematic review. A meta‐analysis with random effects was performed to analyze the effects of salt substitute on systolic and diastolic BP, 24‐h urinary sodium and potassium, and cardiovascular and all‐cause mortality. In the random‐effects model, participants consuming salt substitute showed significant reduction in systolic BP (mean difference (MD) −4.80 mmHg, 95% confidence interval (CI) −6.12 to −3.48, P < 0.0001) and diastolic BP (MD −1.48 mmHg, 95% CI −2.06 to −0.90, P < 0.0001) compared with participants consuming normal salt. In the urine electrolyte analysis, the salt substitute group had significant reduction in 24‐h urine sodium (MD −22.96 mmol/24‐h, P = 0.0001) and significant elevation in 24‐h urine potassium (MD 14.41 mmol/24‐h, P < 0.0001). Of the five studies with mortality outcome data, salt substitute significantly reduced all‐cause mortality (hazard ratio 0.88, P = 0.0003). In conclusion, our analyses showed that salt substitute has a strong effect on lowering BP and reducing all‐cause mortality. By modifying the daily diet with salt substitute, the authors can improve BP control by using this non‐pharmaceutical management.
2022 Thai Hypertension Society guidelines on home blood pressure monitoring
Authors: Kunanon Sirisawat , Roubsanthisuk Weranuj , Chattranukulchai Pairoj , Sangwatanaroj Somkiat , Ophascharoensuk Vuddhidej , Sitthisook Surapun , Sukonthasarn Apichard 
Published: October 2022

AbstractIn 2021, the Universal Health Coverage Payment Scheme of Thailand approved home blood pressure monitoring (HBPM) devices for reimbursement. National utilization of HBPM devices will begin in 2022. This article provides the recommendations for HBPM from the Thai Hypertension Society. In this report, the authors review the benefits of HBPM and recommend confirming the diagnosis of hypertension by HBPM. Devices for HBPM should be the automated and validated upper arm cuff devices. HBPM should be ideally done for seven consecutive days before each clinic visit and take at least two readings (1 min apart) in the morning and before going to bed. The average blood pressure (BP) of 125–134/75–84 mmHg is classified as high normal BP and hypertension is BP of 135/85 mmHg or more. Target BP levels depend on the age of the patients; that is, < 125/75 mmHg for patients aged 18–65 years old, and <135/85 mmHg for patients over 65 years of age.
Epidemiology of inherited epidermolysis bullosa in Germany
Authors: Has Cristina , Hess Moritz , Anemüller Waltraud , Blume‐Peytavi Ulrike , Emmert Steffen , Fölster‐Holst Regina , Frank Jorge , Giehl Kathrin , Günther Claudia , Hammersen Johanna , Hillmann Kathrin , Höflein Bettina , Hoeger Peter H. , Hotz Alrun , Mai Thuy Anh , Oji Vinzenz , Schneider Holm , Süßmuth Kira , Tantcheva‐Póor Iliana , Thielking Frederieke , Zirn Birgit , Fischer Judith , Reimer‐Taschenbrecker Antonia 
Published: October 2022

AbstractBackgroundEpidermolysis bullosa (EB) is a rare genetic disorder manifesting with skin and mucosal membrane blistering in different degrees of severity.ObjectiveEpidemiological data from different countries have been published, but none are available from Germany.MethodsIn this population‐based cross‐sectional study, people living with EB in Germany were identified using the following sources: academic hospitals, diagnostic laboratories and patient organization.ResultsOur study indicates an overall EB incidence of 45 per million live births in Germany. With 14.23 per million live births for junctional EB, the incidence is higher than in other countries, possibly reflecting the availability of early molecular genetic diagnostics in severely affected neonates. Dystrophic EB was assessed at 15.58 cases per million live births. The relatively low incidence found for EB simplex, 14.93 per million live births, could be explained by late or missed diagnosis, but also by 33% of cases remaining not otherwise specified. Using log‐linear models, we estimated a prevalence of 54 per million for all EB types, 2.44 for junctional EB, 12.16 for dystrophic EB and 28.44 per million for EB simplex. These figures are comparable to previously reported data from other countries.ConclusionsAltogether, there are at least 2000 patients with EB in the German population. These results should support national policies and pharmaceutical companies in decision‐making, allow more precise planning of drug development and clinical trials, and aid patient advocacy groups in their effort to improve quality of life of people with this orphan disease.
Strategies for the enhancement of nail plate permeation of drugs to treat onychomycosis
Authors: Gupta Aditya K. , Polla Ravi Shruthi , Choi Su Yong , Konda Adarsh , Cooper Elizabeth A. 
Published: October 2022

AbstractOnychomycosis is caused by dermatophytes, non‐dermatophytes and yeasts. It has a global prevalence of 5.5%, requires long treatment periods, and has high relapse rates following therapy. Oral antifungals are generally the most common treatment. While effective, they have limitations such as drug–drug interactions, hepatotoxicity and adverse side effects; thus, they cannot be used in several populations. Topical antifungals do not have the safety limitations but are typically not as effective. The primary challenge of topical treatment is the permeation of drug molecules across the nail plate barrier, which is a highly cross‐linked keratin network. The use of drugs and formulations with favourable characteristics such as small size, absence of lipophilicity, hydrophilic nature, hydrating properties and appropriate pH can greatly improve permeation. Here, we review physical, nanoparticle‐based, formulation‐based, mechanical and chemical drug delivery strategies to improve the permeation of drugs across the nail plate.