bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of atrial fibrillation recurrence in patients with metabolic syndrome after pulmonary vein isolation
Authors: Ionin V. A. , Zaslavskaya E. L. , Barashkova E. I. , Pavlova V. A. , Ananev A. M. , Morozov A. N. , Baranova E. I. 
Published: September 2022

Aim. To determine the role of biomarkers in predicting atrial fibrillation (AF) recurrence within 12 months after radiofrequency ablation (RFA) in patients with metabolic syndrome (MS).Material and methods. The study included 245 patients with AF aged 35 to 65 years: patients without MS components (n=32), with 1-2 MS components (n=62) and patients with 3 or more MS components (n=153). All patients underwent a comprehensive clinical and anamnestic, anthropometric, laboratory and echocardiographic examinations. The prospective follow-up for 12 months included 135 patients with AF who underwent RFA.Results. It was found that the presence of 3 or more MS components increased the risk of AF recurrence by 4,1 times within 12 months after RFA (relative risk (RR) =4,1, 95% CI 2,19-7,65, p<0,0001). According to binomial logistic regression, epicardial fat thickness (EFT) (OR =3,71, 95% CI 2,12-6,73, p=0,00001), the severity of left atrial fibrosis (OR =1,48, 95% CI 1,03-1,78, p=0,0006), concentrations of galectin-3 (OR =1,31, 95% CI 1,12-1,51, p=0,0001) and GDF-15 (OR =1,11, 95% CI 1,02-1,18, p=0,0002) in patients with AF and MS increase the risk of AF recurrence after RFA. For galectin-3, GDF-15, and EFT, using ROC analysis, the following threshold values were established, the excess of which had the greatest effect on the risk of AF recurrence after RFA in patients with MS: galectin-3 >11,0 ng/ml (RR =3,43, 95% CI 1,79-6,58, p=0,0001), GDF-15 >1380,7 pg/ml (RR =2,84, 95% CI 1,81-4,46, p<0,0001) and EFT >6,4 mm (RR =4,50, 95% CI 2,32-8,71, p<0,0001). In patients with excess of all three biomarker thresholds, the total risk of AF recurrence in patients with MS within 12 months after RFA increases by 3,2 times (RR =3,16, 95% CI 1,97-5,11, p<0,00001).Conclusion. The risk of AF recurrence within 12 months after RFA in patients with three or more MS components is higher than in patients with 1-2 MS components. An increase in the blood concentration of profibrogenic biomarkers galectin-3, GDF-15 and an increase in the thickness of epicardial adipose tissue is associated with an increased risk of AF recurrence in patients with MS, and these biomarkers are likely to play a significant role in predicting recurrent episodes of AF after RFA.
Formation of University students' interest in the teaching profession
Authors: Yerkebulan Duisenbekov , Botagul Turgunbayeva , Nurgul Nurmukhanbetova , Aisulu Shayakhmetova , Aigul Stybayeva 
Published: September 2022

Professional interest can be effective in many areas such as completing the education during university education, effective in the decision to change the field of study, effective in terms of satisfaction with the learning process, and academic success. The aim of this study is to determine the interests of teacher candidates studying at the faculty of education towards the teaching profession. In the research, qualitative research method was used. The study group of the research consists of 250 teacher candidates studying at the education faculties of two different universities in the 2020-2021 academic year. Semi-structured interview forms prepared by the researchers were used as data collection tool. The reason for choosing the qualitative data method is to learn the views of the students in detail. Future generations are the work of teachers. And whether they can do this job in the best way is related to professional interest. If we look at the general result obtained from this research, trainings can be given to increase the attitudes and interests of teacher candidates towards this profession. It can be said that both the answers they gave in the choice of profession and their knowledge about the profession were quite negative.
Keywords: University, education, teacher candidate, interest, professional knowledge
Analisis Sentimen Masyarakat Indonesia terhadap Pemindahan Ibu Kota Negara Indonesia pada Twitter
Authors: Lestari Sri , Mupaat Mupaat , Erfina Adhitia 
Published: September 2022

The relocation state capital of Indonesia raises various responses, especially from the Indonesian people. The discussion related to these issues is very interesting to study, how are the positive and negative sentiments of the Indonesian towards the government's decision. This study aims to analyze the sentiments of the Indonesian people regarding the relocation state capital of Indonesia, including the chosen name of Nusantara on Twitter. In this study, a comparison of 3 algorithms is used, namely the Support Vector Machine (SVM), Naïve Bayes, and K-Nearest Neighbor (KNN) algorithms. From this study, the results obtained are 1,141 positive comments, while negative sentiments are 591 comments. This shows that the Indonesian people have a positive opinion towards the new capital city of Indonesia. In the classification and model testing phase, 10-fold cross validation is used. From these tests, the SVM algorithm obtained an accuracy value of 85.71%, the Naïve Bayes algorithm obtained an accuracy value of 76.70%, the KNN algorithm obtained an accuracy value of 52.74%. This study shows that the SVM algorithm can work better than the Naïve Bayes algorithm and KNN. The accuracy value for the KNN algorithm obtains a low value, this is because the KNN algorithm is sensitive to features that are less relevant.
Sifat Tanah dan Produksi Kopi Liberika pada Ketebalan Gambut yang Berbeda di Jambi
Authors: Ferry Yulius , Hafif Bariot , Sasmita Kurnia Dewi 
Published: September 2022

<p>Ketebalan gambut bervariasi sesuai dengan umur serta jaraknya dari aliran sungai. Ketebalan gambut sangat berhubungan dengan kandungan unsur hara, daya beban lahan, dan kedalaman aras air sehingga berpengaruh terhadap pertumbuhan dan produksi tanaman. Penelitian ini bertujuan untuk mengetahui sifat tanah gambut, pertumbuhan dan produksi tanaman kopi liberika pada beberapa ketebalan gambut. Penelitian dilakukan di desa Mekar Jaya Kecamatan Betara Kabupaten Tanjung Jabung Barat, Jambi. Penelitian dirancang sesuai dengan rancangan acak kelompok, dengan 4 perlakuan yaitu ketebalan: (T1) <span style="text-decoration: underline;">&lt;</span>50 cm, (T2) 50-75 cm, (T3) 76-100 cm, dan (T4) 101-125 cm, dengan jumlah ulangan 6 kali dan ukuran plot 2 x 5 pohon (10 pohon) (90 m<sup>2</sup>). Pengamatan meliputi laju subsiden, sifat kimia tanah, tinggi tanaman, jumlah cabang/tanaman, lilit batang, lebar tajuk, jumlah dompol buah/cabang, jumlah buah/dompol, jumlah buah/tanaman, dan bobot 100 biji. Hasil penelitian menunjukkan bahwa pada ketebalan 101-125 cm memiliki tingkat subsiden yang paling tinggi (4,3 cm/tahun) dan pH paling rendah (3,49). Pertumbuhan dan produksi kopi Liberika terbaik dicapai pada gambut dengan ketebalan 51-75 cm dengan produksinya mencapai 1195,4 buah/pohon/tahun atau 1,37 ton biji/ha/tahun Pada ketebalan 101-125 cm, pertumbuhan vegetatif terhambat dan produksinya paling rendah yaitu sebesar 602,1 buah/pohon/tahun atau 0,56 ton biji/ha/tahun.</p>
PRESERVATION AND HOST PREFERENCES OF LATE FRASNIAN (LATE DEVONIAN) SKELETOBIONTS IN THE APPALACHIAN FORELAND BASIN, USA
Authors: KERR JAMES P. , PIER JALEIGH Q. , BRISSON SARAH K. , BEARD J. ANDREW , BUSH ANDREW M. 
Published: September 2022

AbstractSkeletobionts, organisms that attach to or bore into the skeleton of a host, provide a useful system to observe biological interactions over geological timescales. We examined skeletobionts on brachiopod hosts from a stratigraphic section in western New York State that spanned the Lower Kellwasser and Upper Kellwasser events, the two pulses of the Frasnian–Famennian (Late Devonian) mass extinction. The fossils are largely preserved as molds, and even endoskeletobiont borings are often visible with minimal preparation. At least seven major groups of skeletobiont are present including microconchids, stenolaemate and ctenostome bryozoans, hederelloids, and various borings attributed to sponges. The total frequency of skeletobiosis declined significantly across the first extinction pulse (Lower Kellwasser Event), and relative abundance patterns shifted, although the biotic and/or abiotic drivers of these changes require further study. Multivariable logistic regression indicates that large host body size was a strong and consistent predictor of skeletobiosis. Endoskeletobionts were more common in coarser lithologies, reflecting either an ecological preference for sands over muds or a bias against preservation in mudstones. Endoskeletobionts were also more common on ribbed/costate host shells.
THE OCCURRENCE OF BONE MODIFICATION FEATURES IN THE CARAPACE AND PLASTRON OF THE EXTANT RED-EARED SLIDER TRACHEMYS SCRIPTA ELEGANS (WIED-NEUWIED, 1839): IMPLICATIONS FOR PALEOECOLOGICAL ANALYSES OF FOSSIL TURTLE ASSEMBLAGES
Authors: ZONNEVELD JOHN-PAUL , BARTELS WILLIAM S. 
Published: September 2022

Abstract
The carapace and plastron bones of fossil turtles are often characterized by bone modification features such as pits, grooves, and holes. The significance, origin, and frequency of these features remains unclear because they have not been described from the bones of modern turtles. Taxon-specific description and analyses of defleshed turtle shell is essential for assessing the paleoecological significance of bone modification features. This study focuses on bone modification features on carapace and plastron bones of the emydid turtle Trachemys scripta elegans. Four subadult and 14 adult turtle shells were examined for non-ontogenetic features such as pits, grooves, holes, wounds, abrasions, and pathological growth structures. Bone modification features were lacking on subadult specimens but observed on each adult. Shallow, circular to subcircular pits (similar to the ichnotaxon Karethraichnus lakkos), and to a lesser extent pit clusters, are the most common feature noted on T. scripta elegans shells. Although they occur on both the plastron and the carapace, they proved far more common on the lower shell. Sparsely distributed ring-shaped grooves similar to the ichnotaxon Thatchtelithichnus holmani were present on approximately half of the turtle plastra studied. Amorphous surface etching was observed on several turtles, most commonly near the plastron midline (posterior portion of the hyoplastron/anterior portion of the hypoplastron). Pathological responses to these marks are lacking, but were noted on two turtles in response to sustained injuries. The occurrence of circular and subcircular pits, pit clusters, and ring traces on the external surface of every adult turtle analyzed in this study (regardless of sex or geographical occurrence), their discrete size and shape, and the lack of evidence of a systemic pathological response by the host suggests parasites, possibly leeches, as the etiological agent responsible for these features.
Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4+ T cell
Authors: Matheson Louise , Petkau Georg , Sáenz-Narciso Beatriz , D’Angeli Vanessa , McHugh Jessica , Newman Rebecca , Munford Haydn , West James , Chakraborty Krishnendu , Roberts Jennie , Łukasiak Sebastian , Díaz-Muñoz Manuel , Bell Sarah , Dimeloe Sarah , Turner Martin 
Published: September 2022

Abstract
The ZFP36 family of RNA-binding proteins acts post-transcriptionally to repress translation and promote RNA decay. Studies of genes and pathways regulated by the ZFP36 family in CD4+ T cells have focussed largely on cytokines, but their impact on metabolic reprogramming and differentiation is unclear. Using CD4+ T cells lacking Zfp36 and Zfp36l1, we combined the quantification of mRNA transcription, stability, abundance and translation with crosslinking immunoprecipitation and metabolic profiling to determine how they regulate T cell metabolism and differentiation. We discovered that ZFP36 and ZFP36L1 act directly to limit the expression of genes driving anabolic processes by two distinct routes: by targeting transcription factors and by targeting transcripts encoding rate-limiting enzymes. These enzymes span numerous metabolic pathways including glycolysis, one-carbon metabolism and glutaminolysis. Direct binding and repression of transcripts encoding glutamine transporter SLC38A2 correlated with increased cellular glutamine content in ZFP36/ZFP36L1-deficient T cells. The RBPs limited conversion to αKG by repressing Gls (encoding glutaminase) and Glud1 (encoding glutamate dehydrogenase). We identified ZFP36 and ZFP36L1 as well as glutamine and αKG as limiting factors for the acquisition of the cytotoxic CD4+ T cell fate. Our data reveal roles for ZFP36 and ZFP36L1 in limiting glutamine anaplerosis and differentiation of activated CD4+ T cells, mediated by direct binding to transcripts of critical genes that drive these processes.
The Effects of the Coronavirus Disease Pandemicon Intravenous Thrombolytic Therapy in Patients with Acute Ischemic Stroke in Dalian, China
Authors: Pan Xin , Ma Shubei , Sui Xiaowen , Xie Lili , Li Furong , Cheng Zhengping , Cui Li , Zhao Hongling 
Published: September 2022

Abstract
Objective: We investigated the influence of the coronavirus disease (COVID-19) pandemic on the number of patients with acute ischemic stroke who received intravenous thrombolytic therapy (ITT) in Dalian, China, in 2020.
Methods: This retrospective descriptive study examined 13 stroke emergency map-participating hospitals in Dalian from February 1, 2020, to August 31, 2020. In this “stroke emergency map” of China, patients follow the official WeChat “Stroke Map” account and dial 120 for emergency medical services. We analyzed the number of patients with acute ischemic stroke who underwent ITT. In particular, we examined the onset-to-door time, door-to-needle time (DNT), onset-to-needle time, modes of transportation to the hospital, and National Institutes of Health Stroke Scale (NIHSS) scores before and after ITT. Data were collected for the aforementioned period and compared with the 2021 baseline data from the same period. The Mann‒Whitney U test was performed for data analysis.
Results: Compared with the data from 2020, the number of patients with acute ischemic stroke who underwent ITT increased (from 739 to 1719 cases) in 2021, as did the DNT (from 59 to 45 minutes; P=0.002). Moreover, 83.9% of patients presented to the hospital without ambulance transport versus 81.1% of patients in the 2021 non-COVID-19 pandemic period. Patients with NIHSS scores of 6-14 were more likely to call an ambulance for transport to the hospital than to self-admit to the emergency department.
Conclusions: During the 2020 COVID-19 pandemic, the DNT increased owing to increased surveillance of fever. Furthermore, the number of patients with acute ischemic stroke who underwent ITT also increased in 2021. However, these increases benefited from both the “stroke emergency map” of China and the “green channel,” a novel treatment approach that focuses on the rational design of the rescue process.
The tropical Atlantic as a negative feedback on ENSO
Authors: RICHTER INGO , KOSAKA YU , KIDO SHOICHIRO , TOKINAGA HIROKI 
Published: September 2022

AbstractThe influence of the tropical Atlantic on El Niño-Southern Oscillation (ENSO) is examined using dedicated climate model experiments with sea-surface temperature (SST) restoring. Partial SST restoring to climatology in the tropical Atlantic leads to slower decay of ENSO events and to a shift of the power spectrum to longer periods. Perfect model hindcast experiments with and without restoring tropical Atlantic SST to climatology indicate that both the northern tropical and equatorial Atlantic have a very small influence on ENSO development. During decaying ENSO events, on the other hand, northern tropical Atlantic SST anomalies strongly accelerate the decay. Key to the Atlantic influence on ENSO decay are Atlantic SST anomalies just north of the equator (~ 5N). These lead to local convection anomalies that change the Walker circulation so as to accelerate ENSO decay. Importantly, anomalous events in either the northern tropical or equatorial Atlantic fail to develop in the hindcast ensemble mean, when tropical Pacific SSTs are restored to climatology. This indicates that anomalous tropical Atlantic events in boreal spring and summer are strongly dependent on preceding ENSO events in boreal winter. Thus, the role of the tropical Atlantic is to mediate a negative feedback of ENSO on itself. Despite this passive role of the tropical Atlantic in the Pacific-Atlantic interaction, accurate simulation of the Atlantic feedback should play some role in ENSO prediction. Further model experiments will be required to evaluate model dependence of these findings and to quantify the impact of the Atlantic on ENSO prediction skill.
Predictor factors of root canal treatment quality in undergraduate dental clinics: a two-centered cross-sectional study
Authors: Jardine Alexander Pompermayer , Scarparo Roberta Kchenborger , Pappen Fernanda Geraldo , Zajkowski Lucieli , Kopper Patricia Maria Poli 
Published: September 2022

Abstract
Objectives: To evaluate the prevalence of root canal treatments (RCT) with satisfactory technical quality (TQ) and to determine the pre- and intraoperative factors associated with an unsatisfactory TQ of RCT conducted by undergraduate students.
Material and Methods: This two-centred cross-sectional observational study included periapical radiographs of primary and secondary RCT conducted by undergraduate students at two dental schools (n=462). The TQ of RCT was determined using the ESE criteria, accepting (ASE) or not accepting (NSE) unintentional sealer extrusion. A calibrated examiner analysed pre- and intraoperative variables. Bivariate and multivariate analyses were conducted to identify associations between independent variables and technical outcomes (α=5%).
Results: The TQ of RCT was satisfactory in 45.9% and 62.3% of the cases according to NSE and ASE criteria. Root canal curvature (RCC) (OR=0.95; 95% CI: 0.93, 0.98) and apical root resorption (OR=0.58; 95% CI: 0.35, 0.94) were associated with unsatisfactory TQ according to NSE, but only RCC (OR=0.95; 95% CI: 0.93, 0.97) affected outcomes according to the ASE criterion. Teeth with a RCC greater than 7º and 12º according to NSE and ASE criteria, respectively, were less likely to achieve a satisfactory TQ.
Conclusions: The prevalence of RCT with a satisfactory TQ was comparable to that found in other dental schools and greater when sealer extrusion was accepted. A 12º RCC cutoff point seems to be satisfactory for undergraduate practice. Clinical Relevance: To accept unintentional sealer extrusion increased RCT satisfactory TQ. RCC was the main factor associated with unsatisfactory TQ and might support technical difficulty determination.
Metabolomics-based study of potential biomarkers of sepsis
Authors: Li Yang , Wang Chenglin , Chen Muhu 
Published: September 2022

Abstract
Objective
The purpose of our study was to explore potential characteristic biomarkers in patients with sepsis.
Methods
Peripheral blood specimens from sepsis patients and normal human volunteers were processed by liquid chromatography-mass spectrometry-based analysis. Outlier data were excluded by principal component analysis (PCA) and orthogonal partial least squares-discriminant analysis (OPLS-DA) using the metabolomics R software package metaX and MetaboAnalyst 5.0 (https://www.metaboanalyst.ca/home.xhtml) online analysis software, and differential metabolite counts were identifitied by using volcano and heatmaps. The obtained differential metabolites were combined with KEGG (Kyoto Gene and Kyoto Encyclopedia) analysis to screen out potential core differential metabolites, and ROC curves were drawn to analyze the changes in serum metabolites in sepsis patients and to explore the potential value of the metabolites in the diagnosis of sepsis patients.
Results
By metabolomic analysis, nine differential metabolites were screened for their significance in guiding the diagnosis and differential diagnosis of sepsis namely: 3-phenyl lactic acid, N-phenylacetylglutamine, phenylethylamine, traumatin, xanthine, methyl jasmonate, indole, l-tryptophan and 1107116.
Conclusion
our study was based on metabolomics-based liquid chromatography-mass spectrometry to detect trends in blood species differential metabolites in sepsis patients; nine metabolites in serum could be used as potential characteristic biomarkers for the diagnosis of sepsis patients.
Prophylactic Effect of Ivermectin on SARS-CoV-2 Induced Disease in a Syrian Hamster Model
Authors: Uematsu Takayuki , Takano Tomomi , Matsui Hidehito , Kobayashi Noritada , Hanaki Hideaki 
Published: September 2022

AbstractCOVID-19, caused by SARS-CoV-2 infection, is currently among the most important public health concerns worldwide. Although several effective vaccines have been developed, there is an urgent clinical need for effective pharmaceutical treatments for treatment of COVID-19. Ivermectin, a chemical derivative of avermectin produced byStreptomyces avermitilis, is a macrocyclic lactone with antiparasitic activity. Recent studies have shown that ivermectin inhibits SARS-CoV-2 replicationin vitro. In the present study, we investigated thein vivoeffects of ivermectin in a hamster model of SARS-CoV-2 infection. The results of the present study demonstrate oral administration of ivermectin prior to SARS-CoV-2 infection in hamsters was associated with decreased weight loss and pulmonary inflammation. In addition, the administration of ivermectin reduced pulmonary viral titers and mRNA expression level of pro-inflammatory cytokines associated with severe COVID-19 disease. The administration of ivermectin rapidly induced the production of virus-specific neutralizing antibodies in the late stage of viral infection. Zinc concentrations leading to immune quiescence were also significantly higher in the lungs of ivermectin-treated hamsters compared to controls. These results indicate that ivermectin may have efficacy in reducing the development and severity of COVID-19 by affecting host immunity in a hamster model of SARS-CoV-2 infection.