bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice
Authors: Zhang Zhiguo , Zhong Xiao , Shen Hong , Sheng Liang , Liangpunsakul Suthat , Lok Anna S. , Omary M. Bishr , Wang Shaomeng , Rui Liangyou 
Published: August 2022

AbstractExcessive cholangiocyte expansion (ductular reaction) promotes liver disease progression, but the underlying mechanism is poorly understood. Here we identify biliary NF-κB-inducing kinase (NIK) as a pivotal regulator of ductular reaction. NIK is known to activate the noncanonical IKKα/NF-κB2 pathway and regulate lymphoid tissue development. We find that cholangiocyte NIK is upregulated in mice with cholestasis induced by bile duct ligation (BDL), 5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), or α-naphtyl-isothiocyanate (ANIT). DDC, ANIT, or BDL induces ductular reaction, liver injury, inflammation, and fibrosis in mice. Cholangiocyte-specific deletion of NIK, but not IKKα, blunts these pathological alterations. NIK inhibitor treatment similarly ameliorates DDC-induced ductular reaction, liver injury, and fibrosis. Biliary NIK directly increases cholangiocyte proliferation while suppressing cholangiocyte death, and it also promotes secretion of cholangiokines from cholangiocytes. Cholangiokines stimulate liver macrophages and hepatic stellate cells, augmenting liver inflammation and fibrosis. These results unveil a NIK/ductular reaction axis and a NIK/cholangiokine axis that promote liver disease progression.
A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress
Authors: Griffin Wezley C. , McKinzey David R. , Klinzing Kathleen N. , Baratam Rithvik , Eliyapura Achini , Trakselis Michael A. 
Published: August 2022

AbstractThe minichromosome maintenance (MCM) 8/9 helicase is a AAA+ complex involved in DNA replication-associated repair. Despite high sequence homology to the MCM2-7 helicase, a precise cellular role for MCM8/9 has remained elusive. We have interrogated the DNA synthesis ability and replication fork stability in cells lacking MCM8 or 9 and find that there is a functional partitioning of MCM8/9 activity between promoting replication fork progression and protecting persistently stalled forks. The helicase function of MCM8/9 aids in normal replication fork progression, but upon persistent stalling, MCM8/9 directs additional downstream stabilizers, including BRCA1 and Rad51, to protect forks from excessive degradation. Loss of MCM8 or 9 slows the overall replication rate and allows for excessive nascent strand degradation, detectable by increased markers of genomic damage. This evidence defines multifunctional roles for MCM8/9 in promoting normal replication fork progression and genome integrity following stress.
Comprehensive structural assignment of glycosaminoglycan oligo- and polysaccharides by protein nanopore
Authors: Bayat Parisa , Rambaud Charlotte , Priem Bernard , Bourderioux Matthieu , Bilong Mélanie , Poyer Salomé , Pastoriza-Gallego Manuela , Oukhaled Abdelghani , Mathé Jérôme , Daniel Régis 
Published: August 2022

AbstractGlycosaminoglycans are highly anionic functional polysaccharides with information content in their structure that plays a major role in the communication between the cell and the extracellular environment. The study presented here reports the label-free detection and analysis of glycosaminoglycan molecules at the single molecule level using sensing by biological nanopore, thus addressing the need to decipher structural information in oligo- and polysaccharide sequences, which remains a major challenge for glycoscience. We demonstrate that a wild-type aerolysin nanopore can detect and characterize glycosaminoglycan oligosaccharides with various sulfate patterns, osidic bonds and epimers of uronic acid residues. Size discrimination of tetra- to icosasaccharides from heparin, chondroitin sulfate and dermatan sulfate was investigated and we show that different contents and distributions of sulfate groups can be detected. Remarkably, differences in α/β anomerization and 1,4/1,3 osidic linkages can also be detected in heparosan and hyaluronic acid, as well as the subtle difference between the glucuronic/iduronic epimers in chondroitin and dermatan sulfate. Although, at this stage, discrimination of each of the constituent units of GAGs is not yet achieved at the single-molecule level, the resolution reached in this study is an essential step toward this ultimate goal.
Molecular identification and quantification of defect sites in metal-organic frameworks with NMR probe molecules
Authors: Yin Jinglin , Kang Zhengzhong , Fu Yao , Cao Weicheng , Wang Yiran , Guan Hanxi , Yin Yu , Chen Binbin , Yi Xianfeng , Chen Wei , Shao Wei , Zhu Yihan , Zheng Anmin , Wang Qi , Kong Xueqian 
Published: August 2022

AbstractThe defects in metal-organic frameworks (MOFs) can dramatically alter their pore structure and chemical properties. However, it has been a great challenge to characterize the molecular structure of defects, especially when the defects are distributed irregularly in the lattice. In this work, we applied a characterization strategy based on solid-state nuclear magnetic resonance (NMR) to assess the chemistry of defects. This strategy takes advantage of the coordination-sensitive phosphorus probe molecules, e.g., trimethylphosphine (TMP) and trimethylphosphine oxide (TMPO), that can distinguish the subtle differences in the acidity of defects. A variety of local chemical environments have been identified in defective and ideal MOF lattices. The geometric dimension of defects can also be evaluated by using the homologs of probe molecules with different sizes. In addition, our method provides a reliable way to quantify the density of defect sites, which comes together with the molecular details of local pore environments. The comprehensive solid-state NMR strategy can be of great value for a better understanding of MOF structures and for guiding the design of MOFs with desired catalytic or adsorption properties.
Finger-inspired rigid-soft hybrid tactile sensor with superior sensitivity at high frequency
Authors: Zhang Jinhui , Yao Haimin , Mo Jiaying , Chen Songyue , Xie Yu , Ma Shenglin , Chen Rui , Luo Tao , Ling Weisong , Qin Lifeng , Wang Zuankai , Zhou Wei 
Published: August 2022

AbstractAmong kinds of flexible tactile sensors, piezoelectric tactile sensor has the advantage of fast response for dynamic force detection. However, it suffers from low sensitivity at high-frequency dynamic stimuli. Here, inspired by finger structure—rigid skeleton embedded in muscle, we report a piezoelectric tactile sensor using a rigid-soft hybrid force-transmission-layer in combination with a soft bottom substrate, which not only greatly enhances the force transmission, but also triggers a significantly magnified effect in d31 working mode of the piezoelectric sensory layer, instead of conventional d33 mode. Experiments show that this sensor exhibits a super-high sensitivity of 346.5 pC N−1 (@ 30 Hz), wide bandwidth of 5–600 Hz and a linear force detection range of 0.009–4.3 N, which is ~17 times the theoretical sensitivity of d33 mode. Furthermore, the sensor is able to detect multiple force directions with high reliability, and shows great potential in robotic dynamic tactile sensing.
Contact exposure to neonicotinoid insecticides temporarily suppresses the locomotor activity of Pardosa lugubris agrobiont wolf spiders
Authors: Řezáč Milan , Přibáňová Gabriela , Gloríková Nela , Heneberg Petr 
Published: August 2022

AbstractExposure to numerous chemicals disrupts the spiders' locomotion. Spiders, particularly epigeic spiders, are dependent on their locomotory activities to search for prey, hide from their enemies, and perform sexual reproduction and subsequent parental care. Among the best-known compounds that inhibit the locomotion of arthropods are neonicotinoids. Despite spiders are less affected by the neonicotinoids than insects due to the sequence differences in their acetylcholine receptors, they are not resistant to these compounds. We hypothesized that acute exposure to a broad spectrum of neonicotinoids suppresses the traveled distance, mean velocity, and maximum velocity in epigeic spiders. As a model species, we used adults of Pardosa lugubris. We tested commercial formulations of thiamethoxam, acetamiprid, and thiacloprid. We tested each of the neonicotinoids in the maximum and minimum concentrations recommended for foliar applications. We applied them under controlled conditions dorsally by spraying them directly on the spiders or exposing the spiders to the tarsal contact with neonicotinoid residues. Control groups consisted of 31 individuals; treated groups consisted of 10–21 individuals. We found that a broad spectrum of neonicotinoids temporarily suppresses the traveled distance in epigeic spiders. At 1 h after application, all the three tested neonicotinoid insecticides induced declines in the traveled distance, but this effect mostly disappeared when tested at 24 h after the application. The decrease in the traveled distance was associated with substantial temporary decreases in the mean and maximum velocities. Despite differences among modalities, all three insecticides caused multiple adverse effects on the locomotory parameters in any tested concentrations. It remains to test what would be the lowest safe concentration for the chronic exposure to neonicotinoids in epigeic spiders.
Effect of slow-release nitrogenous fertilizers on dry matter accumulation, grain nutritional quality, water productivity and wheat yield under an arid environment
Authors: Ghafoor Iqra , Rahman Muhammad Habib ur , Hasnain Muhammad Usama , Ikram Rao Muhammad , Khan Mahmood Alam , Iqbal Rashid , Hussain Muhammad Iftikhar , Sabagh Ayman EL 
Published: August 2022

AbstractSlow release nitrogenous fertilizers can improve crops production and reduce the environmental challenges in agro-ecosystem. There is a need to test the efficiency and performance under arid climatic conditions. The study investigates the effect of slow-release fertilizers (urea, neem coated urea (NCU), sulfur coated urea (SCU) and bioactive sulfur coated urea (BSCU)) on the growth, productivity and grain nutritional qualities of wheat crop. Slow-release fertilizers (SRF) with nitrogen levels (130,117,104 and 94 kg ha−1) were applied with equal splits at sowing, 20 and 60 days after sowing (DAS). Research showed that the BSCU with 130 kg ha−1 increased dry matter accumulation (1989 kg ha−1) after anthesis and grain yield 4463 kg ha−1. The higher plant height (102 cm) was attained by 130 kg N ha−1 SCU while the minimum (77.67 cm) recorded for 94 kg N ha−1 as urea source. Maximum grain NPK concentrations (3.54, 0.66 and 1.07%) were recorded by BSCU 130 kg N ha−1 application. While, the minimum NPK (0.77, 0.19 and 0.35%) were observed by Urea 94 kg N ha−1. The high irrigation water use efficiency (WUE) recorded (20.92 kg ha−1 mm−1) and a crop index of 25.52% by BSCU 130 kg N ha−1 application. Research findings show that generally all SRF but particularly BSCU proved effective and can be recommended for wheat crop under arid environment.
Psychological impact on dental students and professionals in a Lima population during COVID-19s wave: a study with predictive models
Authors: Morales-Montoya Mariana , Córdova-Limaylla Nancy , Briceño-Vergel Gissela , Ladera-Castañeda Marysela , Garcia-Luna Goretty , Cachay-Criado Hernán , Cervantes-Ganoza Luis , Cayo-Rojas César F. 
Published: August 2022

AbstractPeru was the country with the highest COVID-19 case fatality rate worldwide during second wave of infection, with dentists and pre-professional students being susceptible to infection due to clinical procedures they perform. This situation could have generated some kind of psychological disorder within this group. Therefore, the present study aimed to assess how COVID-19 pandemic affected this population group during second wave, in relation to depression, anxiety and stress. This observational and cross-sectional study in 368 Peruvian dentists (186 students and 182 professionals), was carried out during August to November 2021. The DASS-21 Scale was used to diagnose depression, anxiety and stress. For the statistical analysis, Pearson's chi-square test was used, in addition to a logit model using odds ratio (OR) to evaluate depression, anxiety and stress with the following factors: gender, age group, marital status, monthly family income, children, academic level, history of COVID-19, COVID-19 symptomatology, close relative with COVID-19, living with vulnerable people and work dedication. In addition, predictive models were constructed considering all possible significant causes. A significance level of p < 0.05 was considered. Dental students and professionals presented significant differences in levels of depression, anxiety and stress (p < 0.001, p = 0.022, p = 0.001; respectively). Male students were 56% less likely to develop stress (OR 0.44; CI 0.22–0.85) compared to females; while those unmarried were 81% less likely to develop stress (OR 0.19; CI 0.04–0.85). Likewise, those with children were 83% less likely to develop stress (OR 0.17; CI 0.06–0.52) and 65% less likely to develop depression (OR 0.35; CI 0.15–0.80). In addition, COVID-19 asymptomatics were 60% less likely to develop depression (OR 0.40; CI 0.17–0.92). However, having relatives with COVID-19 caused almost three times the probability of developing depression (OR 2.96; CI 1.29–6.79) and twice the probability of developing stress (OR 2.49; CI 1.07–5.78). As for dental professionals, it was noticed that those unmarried had almost three times the probability of developing stress (OR 2.93; CI 1.38–6.23); while those who only worked had twice the probability of developing stress (OR 2.37; CI 1.17–4.78). Dental students had a higher prevalence of depression, anxiety and stress. In addition, having children and being asymptomatic were protective predictors for depression, while being male, unmarried and having children were protective predictors for stress. However, having a relative with COVID-19 was a risk predictor for depression and stress. In professionals, only working and being unmarried were risk predictors for stress.
Intensity instability and correlation in amplified multimode wave mixing
Authors: An Haechan , Owens Hal , Ather Hamza , Shakouri Ali , Hosseini Mahdi 
Published: August 2022

AbstractThe dynamics of optical nonlinearity in the presence of gain and feedback can be complex leading to chaos in certain regimes. Temporal, spectral, spatial, or polarization instability of optical fields can emerge from chaotic response of an optical $$\chi ^{(2)}$$

χ

(
2
)

or $$\chi ^{(3)}$$

χ

(
3
)

nonlinear medium placed between two cavity mirrors or before a single feedback mirror. The complex mode dynamics, high-order correlations, and transition to instability in these systems are not well known. We consider a $$\chi ^{(3)}$$

χ

(
3
)

medium with amplified four-wave mixing process and study noise and correlation between multiple optical modes. Although individual modes show intensity instability, we observe relative intensity noise reduction close to the standard quantum noise, limited by the camera speed. We observe a relative noise reduction of more than 20 dB and fourth-order intensity correlation between four spatial modes. More than 100 distinct correlated quadruple modes can be generated using this process.
Predicting mechanical properties of material extrusion additive manufacturing-fabricated structures with limited information
Authors: Peterson Amy M. , Kazmer David O. 
Published: August 2022

AbstractMechanical properties of additively manufactured structures fabricated using material extrusion additive manufacturing are predicted through combining thermal modeling with entanglement theory and molecular dynamics approaches. A one-dimensional model of heat transfer in a single road width wall is created and validated against both thermography and mechanical testing results. Various model modifications are investigated to determine which heat transfer considerations are important to predicting properties. This approach was able to predict tear energies on reasonable scales with minimal information about the polymer. Such an approach is likely to be applicable to a wide range of amorphous and low crystallinity thermoplastics.
Structure parameter design and bench test research of paddy field blades
Authors: Chen Chongcheng , Di Zhifeng , Chen Weixiang , Zheng Shuhe , Ren Jinbo 
Published: August 2022

AbstractAiming at the problems of high labor intensity and low efficiency in manual operation during the pulping process of rice seedling nursing in thin mud in hilly and mountain areas, this paper designed a new type of paddy field blade for seedling nursing, and utilized a rice nursery pulper to help manual operation complete the pulping process. It created a mathematical model of mud-throwing mass and operating power in the operation process of paddy field blade, and obtained the main structure factors that influenced the mud-throwing mass and operating power of paddy field blade, which included the area of mud splashing board, the angle between the front cutting edge and the mud splashing board, and the inclination angle between the front cutting surface and the mud splashing board. To further analyze the degree of influence of the blade’s main structure parameters on mud-throwing mass and operating power, it used EDEM discrete element simulation software to establish a discrete element simulation model of paddy field blade and mud particle system, performed simulation analysis with the method of orthogonal experimental design, and conducted a bench test for comparison. The results showed that: (1) the degree of influence of the three structure parameters on mud-throwing mass and operating power from large to small in order was the area of mud splashing board > the inclination angle between front cutting surface and mud splashing board > the angle between front cutting edge and mud splashing board; (2) the maximum relative error for mud-throwing mass between simulation analysis and bench test was 4.53%, and that for operating power was 8.67%; and (3) three reference parameters combinations were selected by P2-1/M2 graph, the mud-throwing mass of the three combinations was 40.43%, 27.52% and 0.16% higher than that of the original blade, and the power consumed was 13.99%, 21.83% and 36.65% lower than that of the original blade, indicating that the new paddy field blade had good operating performance.
Geometry-modulated dipole polarizability of the two-dimensional Mott-Wannier excitons in gate-defined anisotropic quantum dot
Authors: Poszwa A. 
Published: August 2022

AbstractA theoretical investigation on neutral excitons confined to a mono-layer (ML) semiconductor transition metal dichalcogenide (TMDC) materials under the influence of elliptically deformed gate induced confining potential is presented. It has been shown that the anisotropy of the confinement induces the anisotropy of linear response of the system on in-plane external electric field. The linear response is expressed in terms of principal moments of the static dipole polarizability tensor. In this manner the direction-dependent polarizability of the system can be fully controlled by tuning the parameters of gate-induced confining potential. The components of the polarizability tensor are determined using finite-field method based on the exact diagonalization of the electron-hole Hamiltonian including confining potential, Coulomb electron-hole interaction and an external electric field, within effective mass approximation, close to the K-points of the first Brillouin zone of a single-layer MX$$_2$$

2

material. The useful scaling relations for energies and dipole polarizabilities as functions of material parameters have been found. The influence of the anisotropy of the confining potential on correlated behavior of charge distribution inside the neutral system has also been demonstrated.
The role of electrolyte imbalances in predicting the severity of COVID-19 in the hospitalized patients: a cross-sectional study
Authors: Yasari Fatemeh , Akbarian Meshkat , Abedini Atefeh , Vasheghani Maryam 
Published: August 2022

AbstractCoronavirus disease 2019 (COVID-19) can be fatal in severe cases. Accordingly, predicting the severity and prognosis of the disease is valuable. This study examined the role of electrolyte imbalances in predicting the severity of COVID-19. In this cross-sectional study, 169 hospitalized patients with COVID-19 were included and categorized into three groups based on the severity of the disease (moderate, severe, and critical). Serum levels of electrolytes (calcium [Ca], phosphorus [P], sodium [Na], potassium [k], and magnesium [Mg]), inflammatory markers (D-dimer, C-reactive protein [CRP], ferritin, and lactate dehydrogenase [LDH]), and 25OHVitamin D were measured. The mean age of patients was 53 years, and 54% were male. They had moderate, severe, and critical illnesses in 22%, 47%, and 31%, respectively. CRP, D-dimer, and ferritin increased with the severity of the disease. The lower median values of Mg, Na, 25OHVitamin D, Ca, LDH, and higher median lymphocyte counts were observed in the moderate vs. the severe group (P < 0.05). These parameters have acceptable sensitivity and specificity at the suggested cut-off level to discriminate the moderate and critical cases. Serum parameters introduced in this study are appropriate for differentiating between critical and moderate cases. The electrolyte imbalance can predict critical patients.
An Investigation of Developmental Coordination Disorder Characteristics in Children With Childhood Apraxia of Speech
Authors: Iuzzini-Seigel Jenya , Moorer Laura , Tamplain Priscila 
Published: August 2022

Purpose:
Children with childhood apraxia of speech (CAS) evidence a high rate of co-occurring fine and gross motor deficits. This clinical focus article reports a preliminary investigation of characteristics of developmental coordination disorder (DCD), a neurodevelopmental disorder categorized by poor motor proficiency and functional limitations, in this population.

Method:

Children with CAS underwent a comprehensive motor evaluation using the Movement Assessment Battery for Children–Second Edition, the Developmental Coordination Disorder Questionnaire, and a developmental history questionnaire to determine if they met criteria for a DCD diagnosis as specified in the
Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
(DSM-5).

Results:
Six out of seven participants met DCD criteria based on the DSM-5 criteria. Four of these children had a co-occurring diagnosis of developmental language disorder, and all met criteria for DCD.

Conclusions:
Consistent with previous research, the majority of participants demonstrated motor deficits and 85% met criteria for DCD. Despite this high rate of motor deficits, only 57% had previously undergone a physical/occupational therapy evaluation and intervention and only one had a previous diagnosis of DCD. These findings suggest that formal movement assessments are essential for children with a CAS diagnosis.

Supplemental Material:

https://doi.org/10.23641/asha.20540193