bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of small scale mine rock slope stability and blast induce effect monitoring as a way forward to a sustainable dolomite mining in Akoko Edo, Nigeria
Authors: Taiwo Blessing Olamide , Yewuhalashet F. , Ogunyemi O.B. , Babatuyi V.A , Okobe E.I. , Orhu E.A. 
Published: November 2022

Abstract
Blast-induced noise and ground vibrations are two of the most significant challenges in blast rock fragmentation, and they can have an impact on mine stability and the safety of personnel and machines nearby. As a result, evaluating the slope stability and the contribution of powder factor on ground vibration and noise induced by blasting in small scale mines plays an important role in improving mine sustainability. The results of slope stability assessment and the effect of explosive charge on blast induced ground vibration and noise level at selected carbonate rock quarries in Akoko Edo, Nigeria are presented in this paper. The purpose of this research is to examine the slope stability of a mine using kinematic analysis and slope mass rating techniques, as well as to determine the relationship between powder factor and ground vibration and noise caused by blasting. According to the study results, the average blast induced noise and ground vibration from the nine blast rounds are 123–151 Kb and 2.43 mm/s to 5.03 mm/s, respectively. According to the findings, the powder factor has a positive relationship with blast-induced ground vibration and noise level. The findings also show that the results of SMR and kinematic slope analysis techniques are similar with less variation and can be used to assess slope stability in practice.
The role of experts and expertise in practices of citizen engagement in climate policy: a comparative analysis of two contrasting cases
Authors: Beek Lisette van , Mouter Niek , Pelzer Peter , Hajer Maarten , Vuuren Detlef van 
Published: November 2022

Abstract

The need for engaging citizens in climate policymaking is increasingly recognised. Despite indications that the form of expert involvement can strongly shape the outcomes, this remains scarcely researched. We analysed two unique and contrasting cases of citizen engagement in national climate mitigation policy: 1) the Irish Citizens’ Assembly (ICA), the first national climate assembly involving live expert presentations and face-to-face deliberations; and 2) the Participatory Value Evaluation (PVE) on Dutch climate policymaking, where more than 10,000 citizens compared policy options in an online environment based on expert-based information on policy effects. Taking a dramaturgical approach, we found that the opening-up and closing-down of policy options and perspectives was influenced by the setting, staging and scripting of expertise. The simple and online format of the PVE allows for opening-up towards a diverse set of normative perspectives, but a small set of policy options. In contrast, the deliberative setting of a climate assembly enables deliberation on a wider set of policy options, but a limited range of normative perspectives. Apart from providing information on policy options, experts had significant roles in design choices and formulating recommendations, which further shaped citizens’ deliberations and policy advice. Future research should further investigate the role of experts and expertise across a wider range of practices. Nevertheless, we conclude that the high degree of required technical knowledge in climate mitigation policy naturally implies a strong influence of expert involvement, which concomitantly steers the results. Alternatively, we may search to enhance citizens’ engagement in guiding climate policymakers focusing on citizens’ normative perspectives.
Functional assessment of renal damage in children with primary vesicoureteral reflux
Authors: Zhu Yaju , Li Yufeng , Jin Jing , Ni Jiajia 
Published: November 2022

Abstract
Objectives: To evaluate the renal function damage in children with primary vesicoureteral reflux (VUR).
Methods: A total of 226 children with VUR (65 cases with left, 39 with right, and 122 cases with bilateral VUR) were screened. Eighty-five urinary tract infection (UTI) cases, without urinary malformations, during the same period were collected as controls. Age at diagnosis, body weight, renal ultrasound, VUR grade, serum creatinine level, dimercaptosuccinic acid (DMSA) level, and effective renal plasma flow (ERPF) values were retrospectively analyzed.
Results: There were no significant differences in age at diagnosis between study groups. Total ERPF was significantly lower in the bilateral VUR group than in the control group. The ERPF in unilateral VUR was significantly lower than that in the contralateral or ipsilateral side in the control group (P<0.001). The mean split renal function, as assessed by DMSA of VUR, was 28.00% and 29.12% on the left and right sides, respectively, both of which were lower than the control group’s 40.27%. Renal deterioration was also correlated with renal scarring (P=0.003), a VUR grade (P=0.008), a transverse diameter (P=0.002), and renal pelvic separation (P=0.037).
Conclusion: Split renal function was impaired in the reflux kidney. The total ERPF in the bilateral VUR group was lower than that in the unilateral VUR group. Renal deterioration was correlated with renal scarring, a VUR grade, a transverse diameter, and renal pelvis separation.
Conventional v/s Microsurgical Approach in the Management of Gingival Recession Using De – Epithelialized Gingival Graft - A Randomized Controlled Trial
Authors: Patil Pooja , NK Sowmya , GV Gayathri , MG Triveni 
Published: November 2022

AbstractOBJECTIVE: The use of a surgical microscope in periodontal plastic surgeries enhances the visual perception and illuminates the surgical field leading to precise incisions and adaptation of the flap resulting in aesthetically acceptable root coverage. Hence, the aim of the study was to compare and evaluate the clinical outcome of conventional and microsurgical approaches in the management of isolated gingival recession using a de-epithelialized gingival graft. MATERIAL AND METHODS: 24 patients exhibiting either Miller Class I or II recession were treated using coronally advanced flap with de-epithelialized gingival graft. 12 patients were managed using conventional technique and other 12 patients under surgical microscope. Clinical parameters included gingival index, plaque index, probing depth, recession depth, width of keratinized gingiva, and gingival thickness were measured at baseline and 4 months post-operatively. Visual analog scale for pain was recorded on day 3, 5 and 7 and wound healing index was recorded on 3rd and 5th day. Root surface area covered was analysed using ImageJ software. RESULTS: Both the groups demonstrated clinically significant improvements in terms of clinical parameters from baseline. There was a statistically significant reduction in pain on the 3rd and 5th day in the microsurgical group compared to the conventional group. The microsurgical group showed a significant improvement in healing on 3rd day than the conventional group. CONCLUSION: Within the limits of this study, it can be concluded that the use of magnifying tools like surgical microscope along with microsurgical instruments and sutures aids in aesthetically accepted outcomes with less post-operative morbidity.CLINICAL RELEVANCE:Use of magnification tools aid in precise handling of the tissue and better healing.TRIAL REGISTRATION:Clinical Trials Registry – India, Identification number CTRI/2021/07/035251.
Advanced Design of Axial Rod Type Thermal Conductivity Measurement Setup
Authors: Patel Shahera , Patel Jay Ka. 
Published: November 2022

Abstract
The objective of this work is to develop advanced design of Axial rod type experimental thermal conductivity setup with manual and automatic temperature measurement which is very much useful for research purpose as well as for the Post Graduate students to perform practical in laboratory and understand basic theoretical concepts. The developed set up is already in use for measurement of thermal conductivity for different types of solid materials and crystals. Various methods are used for the measurement of thermal conductivity. We have developed design of axial rod (Brass) type arrangement for steady state measurements. Suitable mechanical arrangement was fabricated for measurement of Top and Bottom temperature of the rod using J-type (Cr-Al) thermocouples. Special Heater with its power supply is designed to change the temperature manually at regular interval of time. The automatic measurement of temperature was also carried out by modifying the design which includes Thermocouple module and Arduino Nano Board. The corresponding measurement of temperatures at different points on Brass rod was carried out and corresponding thermal conductivity of crystal was calculated. Key pad is used to set the time for temperature display at regular interval of time in Minutes/Seconds in advanced design (which can be changed by program). Implications are discussed.
Quadratus lumborum block versus fascia iliaca compartment block for acetabular fracture surgery by Stoppa method: A double-blind prospective randomized controlled clinical trial
Authors: Mirkheshti Alireza , Hashemian Morteza , Abtahi Dariush , Shayegh Sara , Manafi-Rasi Alireza , Sayadi Shahram , Memary Elham , Karami Nazli , Rostamian Baharak , Shakeri Alireza 
Published: November 2022

Abstract
Background: Acetabular fracture surgeries are frequently associated with long and severe perioperative pain, and there is no consensus on pain relief management.
Aim: The purpose of this study was to compare the analgesic efficacy of fascia iliaca compartment block (FICB) and quadratus lumborum block (QLB) in patients with acetabular fractures undergoing surgery using the Stoppa method.
Methods: Adult patients undergoing spinal anesthesia for acetabular fracture surgery were divided into two groups of FICB (n = 22) and QLB (n = 24) in this prospective double-blind randomized parallel clinical study. The pain intensity at different times was evaluated in all participants using the visual analog scale (VAS). The dose of fentanyl required to make the patient sit for spinal anesthesia and the pain intensity was evaluated. The duration of analgesia and the total amount of morphine consumed in the first 24 hours after surgery were also evaluated, analyzed, and compared between the two study groups.
Results: Both FICB and QLB showed effective comparative postoperative analgesic profiles after acetabular fracture surgery; However, no significant variation in VAS values was found at any time of the study between the two groups. FICB showed decreased cumulative fentanyl consumption during spinal anesthetic placement, however, QLB had considerably lower total morphine demand in the initial postoperative 24h period.
Conclusion: The lateral QLB and FICB can introduce as effective routes for analgesia in acetabular fracture surgery by the Stoppa approach.
Clinical Trial Registration: The study was retrospectively registered in the clinical trials registry system, on 2021-02-17, with registration number: IRCT20191114045435N1.
Red Blood Cell Distribution Width is Associated with Short-term Mortality in Critically Ill Patients with Type 2 Diabetes Mellitus
Authors: Chen Fujin , Wang Xiaobo , Ni Bukao , Wu Jianhua , Shi Jincun 
Published: November 2022

AbstractBackground:Red blood cell distribution width (RDW) is associated with increased mortality in many diseases. However, the relationship between RDW fluctuations and the prognosis of critically ill patients with type 2 diabetes mellitus (T2DM) has not been reported. This study investigated the association between baseline RDW levels and dynamic changes and short-term mortality in critically ill patients with T2DM.Methods:All critically ill patients meeting the diagnostic criteria for T2DM in the Medical Information Mart for Intensive Care IV database were retrospectively analyzed. Logistic and Cox regression, Kaplan-Meier survival, and subgroup analyses were used to determine the association between baseline RDW and short-term mortality in critically ill patients with T2DM. Generalized additive mixed models were then used to compare trends in RDW over time between survivors and non-survivors.Results:This study enrolled 6,299 patients with a 28-day mortality rate of 18.4%. Kaplan-Meier analysis showed higher 28-day and 60-day mortality (P<0.001) in the high baseline RDW group. High baseline RDW was revealed by multivariate logistic and Cox regression models as an independent risk factor for in-hospital, 28-day, and 60-day death in critically ill patients with T2DM. An association between elevated baseline RDW and 28-day mortality was observed in all subgroup analyses. The generalized summation mixed-effects model results showed a significant difference in RDW between the surviving and non-surviving groups within 48 h of admission to the intensive care unit (ICU). Moreover, this difference increased with time (β=0.034,P=0.003).Conclusions:Elevated baseline RDW at ICU admission was associated with high short-term mortality in critically ill patients with T2DM, an association that remained significant within 48 h of patient admission to the ICU. Moreover, dynamic monitoring of RDW may help predict short-term mortality in critically ill patients with T2DM. However, this finding requires further validation in prospective studies.
A Meta-analysis of Treatment for Early-Stage Cervical Cancer: Open versus Minimally Invasive Radical Trachelectomy
Authors: Yuan Yi , Wang Yu-ying , Wang Yu-wen , He Jun-jie , Chen Jin-an , Wu Qian-long , Peng Jia-ying , Lin Zi-han , Lv Zi 
Published: November 2022

Abstract
Background In previous systematic reviews, meta-analysis was lacking, resulting in the statistical difference between the data of different surgeries being impossible to judge. This meta-analysis aims to contrast the fertility results and cancer outcomes between open and minimally invasive surgery.
Method We systematically searched databases including PubMed, Embase, Cochrane, and Scopus to collect studies that included open and minimally invasive radical trachelectomy. A random-effect model calculated the weighted average difference of each primary outcome via Review Manager V.5.4.
Result Eight studies (1369 patients) were incorporated into our study. For fertility results, the Open group excels MIS group in pregnancies-Third trimester delivery[OR = 2.68; 95% CI (1.29, 5.59); P = 0.008]. Nevertheless, there were no statistical differences in clinical pregnancy, miscarriage, and second-trimester rate. Concerning cancer outcomes, no difference was detected in the overall survival [OR = 1.56; 95% CI (0.70, 3.45); P = 0.27] and recurrence [OR = 0.63; 95% CI (0.35, 1.12); P = 0.12]. Concerning surgery-related outcomes, the comprehensive effects revealed that the estimated blood loss of the Open group was higher than that of the MIS group[MD = 139.40; 95% CI (79.05, 199.75); P < 0.0001]. However, there was no difference between the postoperative complication rate in the two groups [OR = 1.52; 95% CI (0.89, 2.60); P = 0.12].
Conclusion This meta-analysis suggested that the fertility result of the Open group may be better than the MIS group, while the MIS group has better surgery-related outcomes. Owing to the poor cases of our study, a more robust conclusion requires more relevant articles in the future.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO CRD42022352999
Cuproptosis-related lncRNA signature for prognostic prediction in patients with acute myeloid leukemia
Authors: Zhu Yidong , He Jun , Li Zihua , Yang Wenzhong 
Published: November 2022

Abstract
Background
Long non-coding RNAs (lncRNAs) have been reported to have a crucial impact on the pathogenesis of acute myeloid leukemia (AML). Cuproptosis, a copper-triggered modality of mitochondrial cell death, might be a promising therapeutic target for cancer treatment. Nevertheless, the role of cuproptosis-related lncRNAs in AML remains unexplored.
Methods
AML RNA sequencing data and demographical characteristics were downloaded from The Cancer Genome Atlas (TCGA) database. Pearson correlation analysis, the least absolute shrinkage and selection operator (LASSO) regression algorithm, and univariable and multivariable Cox regression analyses were applied to identify the cuproptosis-related lncRNA signature and determine its feasibility it for AML prognosis prediction. The performance of the proposed signature was measured via Kaplan-Meier survival analysis, receiver operating characteristic (ROC) curves, and principal component analysis (PCA). Functional analysis was implemented to uncover the potential prognostic mechanisms. Moreover, quantitative real-time PCR (qRT-PCR) was used to validate the expression of the prognostic lncRNAs in clinical samples.
Results
A signature consisting of seven cuproptosis-related lncRNA (NFE4, LINC00989, LINC02062, AC006460.2, AL353796.1, PSMB8-AS1, and AC000120.1) was identified. Multivariable cox regression analysis revealed that the proposed lncRNA signature was an independent prognostic factor for AML, the nomogram based on this signature showed excellent accuracy in predicting 1-, 3-, and 5-year survival [Area Under Curve (AUC) = 0.846, 0.801, and 0.895, respectively]. Functional analysis suggested a significant association between the prognostic signature and the immune-related pathways. The expression pattern of the lncRNAs was validated in AML samples, which suggested the robustness of these findings.
Conclusion
In this study, we constructed a prediction model based on seven cuproptosis-related lncRNAs for AML prognosis. The obtained risk score may be connected with tumor immunity.
Role of laparoscopic loop sigmoid colostomy in a case of Fournier’s gangrene with parietal wall abscess and complex perineopelvic fistula causing pelvic sepsis
Authors: Roy Gradlin , B Elangovan , P Sirisha 
Published: November 2022

Abstract
Background
Fournier’s gangrene is a rapidly progressive necrotizing fasciitis of scrotum and perineal region. The cornerstone of treatment is early detection, aggressive surgical debridement along with complete drainage of abscess and also optimal medical management.
Methods
This patient with Fournier's gangrene who underwent emergency surgical debridement and abscess drainage, followed by serial debridement’s in our institution had an unusual presentation. Because of constant fecal contamination of the wound along with development of multiple fistulous tract communicating to anterior abdominal wall and pelvis, there was ascending infection leading to pelvic sepsis and parietal wall abscess. Hence MR Fistulogram and Pelvis was recommended. The patient was successfully managed by Laparoscopic loop sigmoid for control of sepsis and faster recovery. In this patient, Laparoscopic mobilization and exteriorization of the sigmoid loop through widening the left utility port incision was found to be simple and easily reproducible technique in creating loop sigmoid colostomy. The operative time for our case was 65 minutes, making it feasible even for the surgeon without extensive laparoscopy experience.
Results
Postoperatively patient had a faster recovery, wound infection settled and secondary suturing of the wound was done. Patient was discharged for later colostomy reversal.
Conclusion
In our experience we found that patient with Fournier gangrene and complex perineal wound causing pelvic sepsis can be managed with laparoscopic fecal diversion for sepsis control and faster wound recovery
Population genetic structure of Aedes albopictus (Diptera: Culicidae) in China inferred by microsatellite and association with knockdown resistance mutations
Authors: Shan Wenqi , Yuan Hao , Chen Hanming , Dong Haowei , Zhou Qiuming , Tao Feng , Bai Jie , Chen Huiying , Ma Yajun , Peng Heng 
Published: November 2022

Abstract
Background: Aedes albopictus is considered to be the main vector of dengue fever and Chikungunya fever in China. Mosquito control is an important component of the integrated programs to prevent dengue fever transmission. In this study, to provide technical support for future genetic control of mosquitoes, the genetic structure of Ae. albopictus population in China was analyzed and the correlation between genetic variations within Ae. albopictus population and kdr mutation was explored.
Methods: Seventeen collection sites from 11 provinces (municipalities) of Ae. albopictus were collected from 2016 to 2021 in China, including most regions in the distribution area. Genomic DNA was extracted from individual adult mosquito using the DNAzol reagent. Eight microsatellite loci were finally selected for genotyping. Population genetic structure and demographic inference were analyzed using the software. Pearson correlation coefficient R was used to examine the association between the intra-population genetic variation and kdr mutation.
Results: The considered eight microsatellite loci, scored in 453 mosquitoes across the 17 localities from North to South of China. The variation analysis showed that most variation occurred within individuals, whereas only about 9% of the total variation was detected among populations. Three gene pools were inferred by Bayesian analysis, in which the overall trend was that the northern populations belong to gene pool I (red), the eastern populations belong to III (blue), and the southern populations belong to three different gene pools. We also observed that the greater the genetic difference (FST), the lower the wild-type frequency of F1534 of VSGC gene in the same population.
Conclusions: The degree of genetic divergence of Ae. albopictus in China was very low among the populations. These populations can be divided into three genetic gene pools. The gene pool of the northern and eastern Chinese populations was relatively simple, and southern populations were heterogeneous. The greater the genetic difference within the population, the larger the mutation rate of knockdown resistance, indicating that frequent migration among Ae. albopictus populations in China maybe a major factor in the increasing insecticide resistance.
Experimental study and finite element analysis of notch effect on HDPE pipes’ resistance under internal pressure
Authors: Abdelwahab Zerrouki , Abdelkader Boulenouar , Abderazek Hammoudi , Tayeb Belfekroune , NOUIOUA Mourad 
Published: November 2022

Abstract
This work aims to study the notch effect in HDPE pipes. Burst tests were performed on notched pipes of HDPE for different depth ratios a/t to evaluate the burst pressure equivalent to each notch depth. 3D finite elements calculations were performed in the frame of elastic-plastic behavior, to predict the Von-Mises equivalent stress values at different positions of notch vicinity. Critical values of Von-Mises equivalent stress were predicted for different notch shapes and depths, also for different hydrostatic pressure levels. According to the obtained results, burst pressure value depends strongly on the notch depth. Hence, equivalent stress takes its maximum values in the immediate vicinity of the notch and then, gradually decreases through the outer pipes limit.