bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between total dairy, high-fat dairy and low-fat dairy intake, and depressive symptoms: findings from a population-based cross-sectional study
Authors: Hockey Meghan , Mohebbi Mohammadreza , Tolmunen Tommi , Hantunen Sari , Tuomainen Tomi-Pekka , Macpherson Helen , Jacka Felice N. , Virtanen Jyrki K. , Rocks Tetyana , Ruusunen Anu 
Published: August 2022

Abstract
Purpose
Evidence on the association between dairy intake and depression is conflicting. Given numerous dietary guidelines recommend the consumption of low-fat dairy products, this study examined associations between total dairy, high-fat dairy, and low-fat dairy intake and the prevalence of elevated depressive symptoms. Associations between dairy products, which differed in both fat content and fermentation status, and depressive symptoms were also explored.

Methods
This cross-sectional study included 1600 Finnish adults (mean age 63 ± 6 years; 51% female) recruited as part of the Kuopio Ischaemic Heart Disease Risk Factor Study. Dairy intake was assessed using 4-day food records. Elevated depressive symptoms were defined as having a score ≥ 5 on the Diagnostic and Statistical Manual of Mental Disorders-III Depression Scale, and/or regularly using one or more prescription drugs for depressive symptoms.

Results
In total, 166 participants (10.4%) reported having elevated depressive symptoms. Using multivariate logistic regression models, intake in the highest tertile of high-fat dairy products (OR 0.64, 95% CI 0.41–0.998, p trend = 0.04) and high-fat non-fermented dairy products (OR 0.60, 95% CI 0.39–0.92, p trend = 0.02) were associated with reduced odds for having elevated depressive symptoms. Whereas no significant association was observed between intake of total dairy, low-fat dairy, or other dairy products, and depressive symptoms.

Conclusion
Higher intake of high-fat dairy and high-fat non-fermented dairy products were associated with reduced odds for having elevated depressive symptoms in middle-aged and older Finnish adults. Given the high global consumption of dairy products, and widespread burden of depression, longitudinal studies that seek to corroborate these findings are required.
Self-perceived dysphagia in non-invasively ventilated COVID-19 patients
Authors: Shadi Mariam S. , Farahat Mohamed 
Published: August 2022

Abstract
Purpose
COVID-19 is known to present with a wide range of clinical symptoms. COVID-19-related dysphagia has been frequently investigated in patients who were critically ill and mechanically ventilated, but not in those with less severe presentations. This study aims to identify the frequency, characteristics, and severity of self-perceived oropharyngeal dysphagia in non-intubated COVID-19 patients.

Methods
In this cross-sectional study, data were collected from patients using a self-administered questionnaire that included the Eating Assessment Tool (EAT-10).

Results
The study included 359 participants with a median age of 34 (range: 18–65) years. Self-perceived dysphagia (EAT-10 total score > 2) was identified in 64.62%, and their median EAT-10 total score was 13 (range 3–40). The most prevalent symptoms were painful swallowing, affected pleasure of eating, stressful swallowing, and coughing while eating. Age, gender, and hospitalization were not statistically significantly associated with the presence of dysphagia, while re-infection, duration, and severity of COVID-19 diagnosis were. The EAT-10 total score was higher in moderate and severe COVID-19 cases as compared to mild cases, and showed a statistically significant inverse correlation with the duration of COVID-19 (r = − 0.267).

Conclusion
Self-perceived dysphagia was prevalent in non-intubated COVID-19 patients. Its severity was related to that of COVID-19 and its duration.
Homeostatic plasticity of eye movement performance in Xenopus tadpoles following prolonged visual image motion stimulation
Authors: Forsthofer Michael , Straka Hans 
Published: August 2022

AbstractVisual image motion-driven ocular motor behaviors such as the optokinetic reflex (OKR) provide sensory feedback for optimizing gaze stability during head/body motion. The performance of this visuo-motor reflex is subject to plastic alterations depending on requirements imposed by specific eco-physiological or developmental circumstances. While visuo-motor plasticity can be experimentally induced by various combinations of motion-related stimuli, the extent to which such evoked behavioral alterations contribute to the behavioral demands of an environment remains often obscure. Here, we used isolated preparations of Xenopus laevis tadpoles to assess the extent and ontogenetic dependency of visuo-motor plasticity during prolonged visual image motion. While a reliable attenuation of large OKR amplitudes can be induced already in young larvae, a robust response magnitude-dependent bidirectional plasticity is present only at older developmental stages. The possibility of older larvae to faithfully enhance small OKR amplitudes coincides with the developmental maturation of inferior olivary–Purkinje cell signal integration. This conclusion was supported by the loss of behavioral plasticity following transection of the climbing fiber pathway and by the immunohistochemical demonstration of a considerable volumetric extension of the Purkinje cell dendritic area between the two tested stages. The bidirectional behavioral alterations with different developmental onsets might functionally serve to standardize the motor output, comparable to the known differential adaptability of vestibulo-ocular reflexes in these animals. This homeostatic plasticity potentially equilibrates the working range of ocular motor behaviors during altered visuo-vestibular conditions or prolonged head/body motion to fine-tune resultant eye movements.
A comparative histological study of the effect of TheraCal LC and biodentine on direct pulp capping in rabbits: an experimental study
Authors: Kayad Mahmoud , Koura Azza , El-Nozahy Amira 
Published: August 2022

Abstract

Objectives
This study histologically compared the effect of TheraCal LC and biodentine on direct pulp capping using a rabbit model.

Materials and methods
A direct pulp capping procedure was performed on 40 mandibular central incisors of 20 healthy, male New Zealand white rabbits. TheraCal LC and biodentine were applied to exposed pulp and 10 randomly selected rabbits were euthanized after the first and second week. Incisors were extracted and prepared for histological processing and examination to check the dentine bridge thickness, continuity, and extent of pulp inflammation. A blinded data analysis was performed, and groups were compared using a Wilcoxon signed-rank test while changes across time within each group were assessed using the Mann–Whitney U test.

Results
When comparing the dentine bridge thickness, biodentine showed a significantly thicker dentine bridge in the first and second week (mean 28.16 µm, 33.66 µm), while TheraCal LC showed a dentine bridge in the second week only (mean 15.93 µm). Regarding dentine bridge continuity, biodentine showed a significantly better dentine bridge in the first week. Additionally, there was no difference in the second week. Furthermore, there was no statistically significant difference between each of the materials regarding the extent of inflammation.

Conclusions
Biodentine in vivo showed better results concerning thickness and continuity of the dentine bridge after direct pulp capping in rabbit incisors. Both biodentine and TheraCal LC had a similar inflammatory effect on the pulp.

Clinical relevance
Biodentine is more successful as a direct pulp capping material compared to TheraCal LC.
Employee perception of managers’ attitudes towards older workers is associated with risk of loss of paid work before state pension age: prospective cohort study with register follow-up
Authors: Meng Annette , Sundstrup Emil , Andersen Lars L. 
Published: August 2022

AbstractIt is increasingly urgent to retain older workers in the workforce. In the present study, we analysed the prospective associations between employees’ perceptions of their managers’ attitudes towards older workers, and of having experienced age discrimination in the labour market with the risk of loss of paid work before the state pension age. Questionnaire data from 10,320 currently employed workers aged 50 + on perceptions of managers’ attitudes towards older workers and perceived age discrimination were collected at baseline in the SeniorWorkingLife study. Data on labour market affiliation were obtained from national registers at baseline and two-year follow-up. Results show that the perception of negative attitudes was prospectively associated with an increased risk of loss of paid work for three of the five negative attitudes “older workers create conflicts, their qualifications are outdated, and they cannot keep up with the pace and development”. Perception of positive attitudes was prospectively associated with a reduced risk of loss of paid work. The perception of age discrimination was prospectively associated with an increased risk of loss of paid work. The results strengthen existing evidence on associations between ageism and labour market attachment, by applying a longitudinal design and including actual change in labour market participation. However, some negative attitudes may be more detrimental to the older workers’ labour market participation. Employees’ positive perceptions of managers’ attitudes reduced the risk. Good relations between employees and managers appear to be important for retaining older workers in the labour market.
Hydrocarbon Identification and Bedding Fracture Detection in Shale Gas Reservoirs Based on a Novel Seismic Dispersion Attribute Inversion Method
Authors: Guo Zhiqi , Zhang Xiaodong , Liu Cai , Liu Xiwu , Liu Yuwei 
Published: August 2022

Abstract
Prediction of hydrocarbon enrichment and natural fractures is significant for sweet spot characterization in shale gas reservoirs. However, it is difficult to estimate reservoir properties using conventional seismic techniques based on elastic and isotropic assumptions. Considering that the viscoelastic anisotropic model better represents organic shale, we propose a new seismic inversion method to improve shale gas characterization by incorporating the anisotropic reflectivity theory in the frequency-dependent inversion scheme. The computed P-wave velocity dispersion attribute DP evaluates the hydrocarbon enrichment by estimating the inelastic properties of shale associated with organic materials. The inverted anisotropic dispersion attribute Dε detects the development intensity of bedding fractures using frequency-dependent anisotropy owing to wave-induced fluid flow in parallel fractures. Synthetic tests indicate that DP can robustly estimate shale attenuation and Dε is sensitive to the frequency-dependent anisotropy of shale. The results are validated by reservoir properties measured in gas-producing boreholes and rock physical modeling analysis, supporting the applicability of the dispersion attributes for hydrocarbon identification and bedding fracture detection. The predicted hydrocarbon enrichment and the development of bedding fractures correlate with the structural characteristics of the shale formation. The depth-related shale properties can be described by improving the geological understanding of the study area. Finally, favorable areas with high hydrocarbon enrichment and extensive development of bedding fractures are identified by simultaneously considering high DP and Dε anomalies, providing essential information for predicting potential shale gas reservoirs.

Article Highlights

A novel seismic inversion method for anisotropy dispersion attributes is proposed

P-wave velocity dispersion attribute is used to identify hydrocarbon enrichment in shale

Anisotropic dispersion attribute is used to detect bedding fractures in shale
Income taxation and equity: new dominance criteria with a microsimulation application
Authors: Brunori Paolo , Palmisano Flaviana , Peragine Vito 
Published: August 2022

AbstractThis paper addresses the problem of the normative evaluation of income tax systems and income tax reforms. While most of the existing criteria, framed in the utilitarian tradition, are uniquely based on information about individual incomes, this paper, building upon the opportunity egalitarian theory, proposes new equity criteria which take into account also the socio-economic characteristics of individuals. Suitable dominance conditions that can be used to rank alternative tax systems are derived by means of an axiomatic approach. Moreover, the theoretical results are used to assess the redistributive effects of an hypothetical tax reform in Romania through a microsimulation analysis.
Predicting self-exclusion among online gamblers: An empirical real-world study
Authors: Hopfgartner Niklas , Auer Michael , Griffiths Mark D. , Helic Denis 
Published: August 2022

AbstractProtecting gamblers from problematic gambling behavior is a major concern for clinicians, researchers, and gambling regulators. Most gambling operators offer a range of so-called responsible gambling tools to help players better understand and control their gambling behavior. One such tool is voluntary self-exclusion, which allows players to block themselves from gambling for a self-selected period. Using player tracking data from three online gambling platforms operating across six countries, this study empirically investigated the factors that led players to self-exclude. Specifically, the study tested (i) which behavioral features led to future self-exclusion, and (ii) whether monetary gambling intensity features (i.e., amount of stakes, losses, and deposits) additionally improved the prediction. A total of 25,720 online gamblers (13% female; mean age = 39.9 years) were analyzed, of whom 414 (1.61%) had a future self-exclusion. Results showed that higher odds of future self-exclusion across countries was associated with a (i) higher number of previous voluntary limit changes and self-exclusions, (ii) higher number of different payment methods for deposits, (iii) higher average number of deposits per session, and (iv) higher number of different types of games played. In five out of six countries, none of the monetary gambling intensity features appeared to affect the odds of future self-exclusion given the inclusion of the aforementioned behavioral variables. Finally, the study examined whether the identified behavioral variables could be used by machine learning algorithms to predict future self-exclusions and generalize to gambling populations of other countries and operators. Overall, machine learning algorithms were able to generalize to other countries in predicting future self-exclusions.
Reviving tradition-bound products: a case of value co-creation using rhetorical history
Authors: Ishizuka Chikako , Kuo-Che Tseng , Kishi Yasuyuki 
Published: August 2022

AbstractThis study explores the value co-creation framework to revive tradition-bound products using rhetorical history and service-dominant logic. This framework shows the effects of using historical significance to enable value co-creation in a new ecosystem by engaging consumers and local communities without eliminating their traditions. Existing studies merely discuss the methodology of a rhetorical emphasis on the authenticity of traditional industrial firms’ history to attract customers. This study explains the motivation to engage in value co-creation to transform tradition-bound businesses. Through these processes, businesses’ boundaries are thawed, and the customer becomes the advocate and thus, the driver of reviving tradition-bound products.
Global changes in chromatin accessibility and transcription in growth hormone-secreting pituitary adenoma
Authors: Wang Meng , Ji Chenxing , Zhang Yichao , Zhang Zhiqiang , Zhang Yu , Guo Huiping , Qiao Nidan , Zhou Xiang , Cao Xiaoyun , Ye Zhen , Yu Yifei , Melnikov Vladimir , Gong Wei , He Min , Zhang Zhaoyun , Zhao Yao , Wang Xuelong , Wei Gang , Ye Zhao 
Published: August 2022

AbstractPurposeGrowth hormone-secreting pituitary adenoma (GHPA) is an insidious disease with persistent hypersecretion of growth hormone and insulin-like growth factor 1, causing increased morbidity and mortality. Previous studies have investigated the transcription of GHPA. However, the gene regulatory landscape has not been fully characterized. The objective of our study was to unravel the changes in chromatin accessibility and transcription in GHPA.MethodsSix patients diagnosed with GHPA in the Department of Neurosurgery at Huashan Hospital were enrolled in our study. Primary pituitary adenoma tissues and adjacent normal pituitary specimens with no morphologic abnormalities from these six patients were obtained at surgery. RNA sequencing (RNA-seq) and assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) were applied to investigate the underlying relationship between gene expression and chromatin accessibility changes in GHPA.ResultsTotally, 1528 differential expression genes (DEGs) were identified by transcriptomics analyses, including 725 up-regulated and 803 down-regulated. Further, we obtained 64 significantly DEGs including 10 DEGs were elevated and 54 DEGs were negligibly expressed in tumors tissues. The up-regulated DEGs were mainly involved in terms related to synapse formation, nervous system development and secretory pathway. In parallel, 3916 increased and 2895 decreased chromatin-accessible regions were mapped by ATAC-seq. Additionally, the chromatin accessible changes were frequently located adjacent to transcription factor CTCF and Rfx2 binding site.ConclusionsOur results are the first to demonstrate the landscape of chromatin accessibility in GHPA, which may contribute to illustrate the underlying transcriptional regulation mechanism of this disease.
Renin and electrolytes indicate the mineralocorticoid activity of fludrocortisone: a 6 year study in primary adrenal insufficiency
Authors: Ceccato F. , Torchio M. , Tizianel I. , Peleg Falb M. , Barbot M. , Sabbadin C. , Betterle C. , Scaroni C. 
Published: August 2022

Abstract
Context
Fludrocortisone (FC) is the mineralocorticoid (MC) replacement treatment for patients with primary adrenal insufficiency (PAI).

Objective
To explore the dose of FC treatment and its relationship with glucocorticoid therapy, sodium, potassium, renin and clinical parameters.

Setting
Monocentric cohort.

Patients
Data of 193 patients with PAI (130 autoimmune) were collected during baseline (T0), intermediate (T1) and last follow-up visit (T2, respectively, after a mean of 38 and 72 months).

Main outcome measure
Utility of endocrine and clinical parameters to titrate FC dose.

Results
FC dose (50–75 μg/daily) was stable in the follow-up in half patients. The MC activity of FC was dose-dependent: we observed a reduced but significant positive linear correlation between FC dose and sodium (r = 0.132) and negative linear correlation between FC and potassium (r = − 0.162) or renin (r = − 0.131, all p < 0.01). An overall reduction in the FC dose was observed at T2 in the group with longer follow-up (> 60 months, p < 0.05). Higher doses of FC were observed in patients with low-normal renin, especially in autoimmune PAI (86 vs 65 μg/daily, p < 0.05). On the contrary, reduced sodium and increased potassium levels were observed in patients with high renin at T2. The number of cardiovascular events (15 in the whole cohort) was similar in patients sorted by renin levels or FC dose.

Conclusions
Renin and electrolytes can indicate the MC activity of FC treatment: they should be routinely evaluated and used to titrate its dose that can be reduced in the long-term follow-up.
Listening to the Post-script: Intersections Between Improvisation and Indeterminacy in Music and Education
Authors: Wilson Stephanie 
Published: August 2022

AbstractThis article begins by exploring how current educational research describes the role of improvisation in education. Drawing on Biesta’s (2017) discussion of the purpose of the educational task, it then argues for a broader consideration of the role of improvisation in education and its potential to positively disrupt traditional linear timescapes. While discussions of improvisation in education often reference jazz music, this study explores a broader range of indeterminate musical forms to gain different insights. Specifically, it translates Stern’s (1988) Table of Transformational and Musical Hierarchies into a framework for education to support educators in considering the role of improvisation in their design and teaching practice. The adapted conceptual model incorporates the dimensions of complex learning environments described by the Activity-Centred Analysis and Design (ACAD) framework as discussed by Goodyear and Carvalho (2014), and in the process, surfaces the temporal aspects of the ACAD framework for closer examination. The model highlights several factors that take on a more significant role in highly indeterminate educational forms such as silence, absence, openings, and rupture. It also provides an opportunity to reflect on ways in which technology contributes to enabling or constraining improvisational processes in postdigital education. The study contributes to research on the intersection between sound and education, and to making the sonic dimension of education one of more ‘intentional concern’ as described by Ford and Sasaki (2021).
Leveraging on non-causal reasoning techniques for enhancing the cognitive management of highly automated vehicles
Authors: Panagiotopoulos Ilias , Dimitrakopoulos George 
Published: August 2022

AbstractHighly Automated Vehicles (HAVs) are expected to improve the performance of terrestrial transportations by providing safe and efficient travel experience to drivers and passengers. As HAVs will be equipped with different driving automation levels, they should be capable to dynamically adapt their Level of Autonomy (LoA), in order to tackle sudden and recurrent changes in their environment (i.e., inclement weather, complex terrain, unexpected on-road obstacles, etc.). In this respect, HAVs should be able to respond not only on causal reasoning effects, which depend on present and past inputs from the external driving environment, but also on non-causal reasoning situations depending on future states associated with the external driving scene. On the other hand, driver’s personal preferences and profile characteristics should be assessed and managed properly, in order to enhance travel experience. In the light of the above, the present paper aims to tackle these challenges on how cognitive computing enables HAVs to operate each time in the best available LoA by responding quickly to changing environment situations and driver’s preferences. On this basis, an in-vehicle cognitive functionality is introduced, which collects data from various sources (sensor and driver layers), intelligently processing it to the decision-making layer, and finally, selecting the optimal LoA by integrating previous knowledge and experience. The overall approach includes the identification and utilization of a hybrid (data-driven and event-driven) algorithmic process towards reaching intelligent and proactive decisions. An indicative discrete event simulation analysis showcases the efficiency of the developed approach in proactively adapting the vehicle’s LoA.