bluuebunny/crossref_metadata_2025_split huggingface dataset:
Re-framing Built Environment Practice: Towards an Accessible City
Authors: Mechkaroff Nicole , Kaushik Saumya , Jackson Mary Ann 
Published: July 2022

As practising architects in Victoria, Australia, we have observed significant, systemic industry failure, impeding the development of accessible and inclusive cities. Contemporary built environment design practice and design values push ‘accessible design’ to the margins, often considered as an after-thought and only in terms of technical and regulatory compliance. Built environment practice needs to be challenged into deeper ways of thinking – ones that stimulate professional discourse and heighten industry awareness of both its control over built environment accessibility outcomes and, critically, its accountability in serving the public good.Cities invariably comprise neighbourhoods. To begin to understand built environment inaccessibility at the neighbourhood scale, the built environment mindset must change to properly engage with complex, socio-ecological, public-realm (public space) built environments. Design practice must improve its neighbourhood site analysis approach, going beyond private, contractual site boundaries and immediate physical surrounds, to understanding end-user experiences, neighbourhood journeys, and the broader scale of (in)accessibility. Industry attitudes, practice approaches and the way disability is positioned by industry must change to embrace processes that necessitate diverse actors working together across multiple disciplines and sectors with people with disability being core actors in decision-making.We believe that opportunities exist in building industry interest and capacity. Research-informed built environment practice embracing systems-thinking, human rights-based approaches, and transdisciplinarity can be effective for aggravating industry change and the way industry positions disability. This paper adopts an analytical, collaborative autoethnographic approach, examining case studies of neighbourhood-scale accessibility assessment, outputs from activities questioning why built environment practitioners believe inaccessibility exists, and self-reflection on 10 to 35+ years of working in architectural practice. Importantly, this paper argues that in working towards achieving universally accessible public spaces for all, built environment practitioners, and architects in particular, must accept accountability for the impact of their actions on people with disabilities’ lived experiences.

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Understanding Inclusive Placemaking Processes through the Case of Klostergata56 in Norway
Authors: Sokolaj Ursula 
Published: July 2022

Public participation and the placemaking approach are receiving continuously increasing attention and are therefore likely to become, in a near future, the norm of shaping our cities. They are instruments of local democracy, enabling citizens to stake a claim and exercise their influence on the city, repositioning them from recipients to active participants in this shaping. Research has shown that these democratic processes are the best way to ensure better physical environments, while also bringing social development. However, this attempt to shift from government to governance by power redistribution can at times pose a challenge to democracy, by repeating existing power relations between participating actors. If representation is not done right and communities are not equally engaged, the social benefits are at stake and issues of inclusion and exclusion arise. The need for assessment in this field is therefore highly relevant, but little progress has been done in developing measurable evaluation tools.This article is based on action research, following as a case study the process of co-designing Klostergata56, a small, underutilized public space in the Norwegian city of Trondheim. It presents a new framework of evaluating a participatory process, applied to the project to investigate its level of inclusion.Results of the study showed that the process had significant limitations to being inclusive to the expense of marginalized groups, due to unequal participation of stakeholders and differences in levels of nurtured social capital and civic trust. The challenges highlighted by the research make it possible to identify lessons for further processes to be more inclusive. Until such challenges are addressed, participatory placemaking will continue to be a trial-and-error process, therefore bound to repeat, at least to some extent, the inequality patterns present in a society.

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DAMPAK FINANCIAL DISTRESS TERHADAP PERSPEKTIF PASAR PADA PERUSAHAAN RETAIL YANG TERCATAT DI BURSA EFEK INDONESIA TAHUN 2019-2020
Authors: Gilang Fajar Fauzan  , Rinaldo Dito 
Published: July 2022

Abstrak: Penelitian ini bertujuan untuk mengetahui dampak financial distress terhadap perspektif pasar. Data penelitian ini menggunakan data sekunder dari laporan keuangan perusahaan retail yang tercatat di Bursa Efek Indonesia (BEI) tahun 2019-2020. Metode yang digunakan dalam penelitian ini adalah metode deskriptif dan verifikatif. Populasi dalam penelitian ini adalah perusahaan yang tercatat di BEI. Sampel pada penelitian ini menggunakan purposive sampling sebanyak 22 perusahaan. Teknik analisis data menggunakan regresi linier sederhana, koefisien determinasi dan uji t dengan menggunakan software SPSS 25.
Berdasarkan hasl uji koefisien deterimnasi menunjukan nilai R square 0.003 maka dapat disimpulkan bahwa pengaruh financial distress terhadap return saham sebesar 0.3% sedangkan sisanya 99.7% yang dipengaruhi oleh faktor lain yang tidak diteliti. Hasil penelitian ini menunjukan bahwa financial distress tidak berpengaruh secara signifikan terhadap return saham.
Kata Kunci: Financial Distress, Return Saham
Analisis Pernikahan Usia Dini pada Wanita Usia Subur (Data SKAP BKKBN Provinsi Banten 2019)
Authors: Khotimah Husnul , Lindawati Refi 
Published: July 2022

Pernikahan usia dini adalah masalah yang muncul baik di Indonesia maupun di dunia, dari data SKAP Remaja BKKBN Provinsi Banten tahun 2019 banyak yang melakukan pernikahan di bawah usia 18 tahun. Tujuan penelitian ini adalah untuk mengetahui hubungan antara pendidikan, tempat tinggal dan suku dengan pernikahan usia dini pada wanita usia subur di Provinsi Banten tahun 2019. Penelitian ini berjenis kuantitatif analitik dengan pendekatan cross sectional. Variabel independen; pendidikan, tempat tinggal dan suku. Variabel dependen adalah Pernikahan usia dini. Responden seluruh data wanita usia subur yang terdapat pada data SKAP BKKBN Provinsi Banten tahun 2019 berjumlah 1709 orang. Menggunakan data sekunder dari SKAP BKKBN Provinsi Banten tahun 2019. Analisis data bivariat menggunakan chi square. Hasil penelitian menunjukkan bahwa terdapat hubungan bermakna antara pendidikan (P:0,000), tempat tinggal (P:0,000), dan suku (P : 0,000) dengan pernikahan usia dini. Perempuan yang tidak berpendidikan formal beresiko melakukan pernikahan dini, wanita yang bertempat tinggal di pedesaan memiliki kecenderungan menikah secara dini dibandingkan dengan perempuan yang bertempat tinggal di perkotaan serta suku tertentu yang biasa melakukan pernikahan dini.
OPTIMASI GENERAL REGRESSION NEURAL NETWORK DENGAN FRUIT FLY OPTIMIZATION ALGORITHM UNTUK PREDIKSI PEMAKAIAN ARUS LISTRIK PADA PENYULANG
Authors: Dewi Ni Putu Novita Puspa , Adi Nugroho Robertus 
Published: July 2022

Prediksi pemakaian arus listrik yang akurat pada setiap penyulang listrik sangat penting untuk memastikan distribusi listrik berjalan lancar . Hasil prediksi pemakaian listrik dapat digunakan untuk mengetahui berapa banyak produksi listrik yang harus dilakukan demi memenuhi kebutuhan listrik secara menyeluruh. Model prediksi hybrid yang menggabungkan General Regression Neural Network (GRNN) dan algoritma optimasi Fruit Fly Optimization Algorithm (FOA) diusulkan untuk menghasilkan prediksi arus listrik yang akurat dan stabil. FOA digunakan untuk mengoptimasi GRNN untuk menemukan nilai smoothing parameter optimal. Data time-series dari 5 penyulang yang mendistribusikan listrik pada 5 wilayah berbeda digunakan untuk validasi model yang diusulkan. Hasil pengujian menunjukkan bahwa model hybrid FOAGRNN menghasilkan error, ketahanan, dan generalisasi yang lebih baik dalam prediksi ini jika dibandingkan dengan model GRNN saja. Pada pengujian terhadap 5 data testing, FOAGRNN menghasilkan error prediksi lebih kecil yaitu rata-rata Root Mean Square Error sebesar 6,98411 dan Mean Absolute Error 3,44542 dibandingkan.GRNN dengan rata-rata error secara berturut-turut 7,86073 dan 4,21529.
Methane Single Cell Protein: Potential to Secure a Global Protein Supply Against Catastrophic Food Shocks
Authors: García Martínez Juan B. , Pearce Joshua M. , Throup James , Cates Jacob , Lackner Maximilian , Denkenberger David C. 
Published: July 2022

Global catastrophes such as a supervolcanic eruption, asteroid impact, or nuclear winter could cause global agricultural collapse due to reduced sunlight reaching the Earth’s surface. The human civilization’s food production system is unprepared to respond to such events, but methane single cell protein (SCP) could be a key part of the solution. Current preparedness centers around food stockpiling, an excessively expensive solution given that an abrupt sunlight reduction scenario (ASRS) could hamper conventional agriculture for 5–10 years. Instead, it is more cost-effective to consider resilient food production techniques requiring little to no sunlight. This study analyses the potential of SCP produced from methane (natural gas and biogas) as a resilient food source for global catastrophic food shocks from ASRS. The following are quantified: global production potential of methane SCP, capital costs, material and energy requirements, ramp-up rates, and retail prices. In addition, potential bottlenecks for fast deployment are considered. While providing a more valuable, protein-rich product than its alternatives, the production capacity could be slower to ramp up. Based on 24/7 construction of facilities, 7%–11% of the global protein requirements could be fulfilled at the end of the first year. Despite significant remaining uncertainties, methane SCP shows significant potential to prevent global protein starvation during an ASRS at an affordable price—US$3–5/kg dry.
Fabrication of “electroactive cells” using bio-inspired polydopamine-derived carbon nanoparticles for manipulation of cells with electrical stimulation
Authors: Li Fang-Yi , Chung Yi-Chang 
Published: July 2022

In this study, we report some bio-inspired carbon nanoparticles (CNPs) that exhibit high fluorescence quantum yields, good conductivity, excellent dispersion in aqueous solution, high cell-uptake efficiency, and no cytotoxicity as well. We were inspired by mussels’ adhesive components to synthesize polydopamine nanoparticles and then use a carbonization process to prepare fluorescent CNPs. Using some surfactants, we could control the sizes of CNPs and increase their dispersion in water. Fluorescence spectroscopy confirmed the excitation of CNPs at 360 nm and emission of blue light with a 400–450 nm wavelength. High quantum yields of greater than 20% were also measured. Transmission electron microscopy proved that the addition of surfactants could shrink particles to several nanometers in size. The fluorescent and conductive CNPs were applied to stain L929 fibroblast cells in vitro, finding no harmful effects on cells. Due to the polydopamine-derived CNPs’ good electrical, fluorescent, and biocompatible response, we designed a platform to manipulate the cells after endocytosis of conductive CNPs to observe the effects of electrical stimulation on cell attachment, cell growth, and cell death. The nanoparticles endocytosed by cells seemed more easily attracted to the electric field, leading to enhanced cell attachment and growth. Therefore, CNP uptake can increase the attachment of cells onto a conductive plate electrode in a short time (within 10 min at 4°C). When the source of the electric field was changed to rod electrodes in the medium, cells that had been pre-adsorbed onto a non-conductive plate were desorbed from the plate and destroyed. Therefore, addition of CNPs during cell incubation can allow control of cell growth and death via manipulation of electric fields.
Barriers to Uptake of Open-Source Automated Insulin Delivery Systems: Analysis of Socioeconomic Factors and Perceived Challenges of Caregivers of Children and Adolescents With Type 1 Diabetes From the OPEN Survey
Authors: Huhndt Antonia , Chen Yanbing , O’Donnell Shane , Cooper Drew , Ballhausen Hanne , Gajewska Katarzyna A. , Froment Timothée , Wäldchen Mandy , Lewis Dana M. , Raile Klemens , Skinner Timothy C. , Braune Katarina 
Published: July 2022

BackgroundAs a treatment option for people living with diabetes, automated insulin delivery (AID) systems are becoming increasingly popular. The #WeAreNotWaiting community plays a crucial role in the provision and distribution of open-source AID technology. However, while a large percentage of children were early adopters of open-source AID, there are regional differences in adoption, which has prompted an investigation into the barriers perceived by caregivers of children with diabetes to creating open-source systems.MethodsThis is a retrospective, cross-sectional and multinational study conducted with caregivers of children and adolescents with diabetes, distributed across the online #WeAreNotWaiting online peer-support groups. Participants—specifically caregivers of children not using AID—responded to a web-based questionnaire concerning their perceived barriers to building and maintaining an open-source AID system.Results56 caregivers of children with diabetes, who were not using open-source AID at the time of data collection responded to the questionnaire. Respondents indicated that their major perceived barriers to building an open-source AID system were their limited technical skills (50%), a lack of support by medical professionals (39%), and therefore the concern with not being able to maintain an AID system (43%). However, barriers relating to confidence in open-source technologies/unapproved products and fear of digital technology taking control of diabetes were not perceived as significant enough to prevent non-users from initiating the use of an open-source AID system.ConclusionsThe results of this study elucidate some of the perceived barriers to uptake of open-source AID experienced by caregivers of children with diabetes. Reducing these barriers may improve the uptake of open-source AID technology for children and adolescents with diabetes. With the continuous development and wider dissemination of educational resources and guidance—for both aspiring users and their healthcare professionals—the adoption of open-source AID systems could be improved.
Candida species and selected behavioral factors co-associated with severe early childhood caries: Case-control study
Authors: Cvanova Michaela , Ruzicka Filip , Kukletova Martina , Lipovy Bretislav , Gachova Daniela , Izakovicova Holla Lydie , Danek Zdenek , Hola Veronika , Bartosova Michaela , Jarkovsky Jiri , Dusek Ladislav , Borilova Linhartova Petra 
Published: July 2022

Severe Early Childhood Caries (sECC) is a multifactorial disease associated with the occurrence of specific oral microorganisms and other environmental, behavioral, and genetic factors. This study aimed to construct a multivariable model including the occurrence ofCandidaspp. and selected behavioral factors (length of breastfeeding, serving sweet beverages and beginning of brushing child’s teeth) to determine their relationships to the occurrence of sECC.In this case-control study 164 children with sECC and 147 children without dental caries were included. MALDI-TOF MS and multiplex qPCR were used to identifyCandidaspp. and selected bacteria in dental plaque samples, respectively. A questionnaire on oral hygiene, diet, and children’s health was filled in by the parents.The constructed multivariable logistic regression model showed an independent influence of the microbial and behavioral factors in sECC etiopathogenesis. The occurrence ofC. albicansandC. dubliniensiswas associated with higher odds of sECC development (odds ratio, OR: 9.62 and 16.93, respectively), together with breastfeeding of 6 months or less (OR: 2.71), exposure to sweet beverages (OR: 3.77), and starting to brush child’s teeth after the 12thmonth of age (OR: 4.10), all statistically significant (p&lt; 0.01).Considering the high occurrence ofC. albicansandC. dubliniensisin dental plaque in children with sECC, we propose them as “keystone pathogens” and risk factors for sECC. The models showed that presence of specific species ofCandidain dental plaque may be a better descriptor of sECC than the mentioned behavioral factors.
Prognostic value of the PDW/HDL-C ratio in patients with chest pain symptoms and coronary artery calcification
Authors: Qiu Ya-Jing , Luo Jun-Yi , Luo Fan , Tian Xin-Xin , Zeng Lu , Zhang Zhuo-Ran , Li Xiao-Mei , Yang Yi-Ning 
Published: July 2022

BackgroundPlatelet-related parameters and HDL-C have been regarded as reliable and alternative markers of coronary heart disease (CHD) and the independent predictors of cardiovascular outcomes. PDW is a simple platelet index, which increases during platelet activation. Whether the PDW/HDL-C ratio predicts major adverse cardiovascular and cerebrovascular events (MACCEs) in patients who complained of chest pain and confirmed coronary artery calcification remains to be investigated. This study aimed to investigate the prognostic value of the PDW/HDL-C ratio in patients with chest pain symptoms and coronary artery calcification.MethodsA total of 5,647 patients with chest pain who underwent coronary computer tomography angiography (CTA) were enrolled in this study. Patients were divided into two groups according to their PDW/HDL-C ratio or whether the MACCE occurs. The primary outcomes were new-onset MACCEs, defined as the composite of all-cause death, non-fatal MI, non-fatal stroke, revascularization, malignant arrhythmia, and severe heart failure.ResultsAll patients had varying degrees of coronary calcification, with a mean CACS of 97.60 (22.60, 942.75), and the level of CACS in the MACCEs group was significantly higher than that in non-MACCE (P&lt;0.001). During the 89-month follow-up, 304 (5.38%) MACCEs were recorded. The incidence of MACCEs was significantly higher in patients with the PDW/HDL-C ratio &gt; 13.33. The K–M survival curves showed that patients in the high PDW/HDL-C ratio group had significantly lower survival rates than patients in the low PDW/HDL-C ratio group (log-rank test: P &lt; 0.001). Multivariate Cox hazard regression analysis reveals that the PDW/HDL ratio was an independent predictor of MACCEs (HR: 1.604, 95% CI: 1.263–2.035; P &lt; 0.001). Cox regression analysis showed that participants with a lower PDW/HDL-C ratio had a higher risk of MACCEs than those in the higher ratio group. The incidence of MACCEs was also more common in the PDW/HDL-C ratio &gt; 13.33 group among different severities of coronary artery calcification. Furthermore, adding the PDW/HDL-C ratio to the traditional prognostic model for MACCEs improved C-statistic (P &lt; 0.001), the NRI value (11.3% improvement, 95% CI: 0.018–0.196, P = 0.01), and the IDI value (0.7% improvement, 95% CI: 0.003–0.010, P &lt; 0.001).ConclusionThe higher PDW/HDL-C ratio was independently associated with the increasing risk of MACCEs in patients with chest pain symptoms and coronary artery calcification. In patients with moderate calcification, mild coronary artery stenosis, and CAD verified by CTA, the incidence of MACCEs increased significantly in the PDW/HDL-C ratio &gt; 13.33 group. Adding the PDW/HDL-C ratio to the traditional model provided had an incremental prognostic value for MACCEs.
Quantitative analysis of heart rate variability parameter and mental stress index
Authors: Luo Jiasai , Zhang Guo , Su Yiwei , Lu Yi , Pang Yu , Wang Yuanfa , Wang Huiqian , Cui Kunfeng , Jiang Yuhao , Zhong Lisha , Huang Zhiwei 
Published: July 2022

BackgroundCardiovascular disease not only occurs in the elderly but also tends to become a common social health problem. Considering the fast pace of modern life, quantified heart rate variability (HRV) indicators combined with the convenience of wearable devices are of great significance for intelligent telemedicine. To quantify the changes in human mental state, this article proposes an improved differential threshold algorithm for R-wave detection and recognition of electrocardiogram (ECG) signals.MethodsHRV is a specific quantitative indicator of autonomic nerve regulation of the heart. The recognition rate is increased by improving the starting position of R wave and the time-window function of the traditional differential threshold method. The experimental platform is a wearable sign monitoring system constructed based on body area networks (BAN) technology. Analytic hierarchy process (AHP) is used to construct the mental stress assessment model, the weight judgment matrix is constructed according to the influence degree of HRV analysis parameters on mental stress, and the consistency check is carried out to obtain the weight value of the corresponding HRV analysis parameters.ResultsExperimental results show that the recognition rate of R wave of real-time 5 min ECG data collected by this algorithm is &gt;99%. The comprehensive index of HRV based on weight matrix can greatly reduce the deviation caused by the measurement error of each parameter. Compared with traditional characteristic wave recognition algorithms, the proposed algorithm simplifies the process, has high real-time performance, and is suitable for wearable analysis devices with low-configuration requirements.ConclusionOur algorithm can describe the mental stress of the body quantitatively and meet the requirements of application demonstration.
Efficacy and safety of Puerarin injection on acute heart failure: A systematic review and meta-analysis
Authors: Li Zunjiang , Fan Ye , Huang Chunxia , Liu Quanle , Huang Manhua , Chen Baijian , Peng Zhe , Zhu Wei , Ding Banghan 
Published: July 2022

ObjectiveThis study aimed to assess the adjunctive efficacy and safety of Puerarin injection (PI) on acute heart failure (AHF) based on a systematic review and meta-analysis.MethodsNine databases were searched from March 1990 to March 2022 to identify randomized controlled trials (RCTs) related to the adjunctive treatment of PI for AHF. The Cochrane collaboration tool was used to assess the risk of bias in the included studies. Meta-analysis and subgroup and sensitivity analyses were conducted by RevMan 5.3 software. The evidence’s certainty was evaluated by grading recommendations assessment, development, and evaluation (GRADE) methods.ResultsA total of 8 studies were included with a total of 614 patients with AHF. The meta-analysis demonstrated that adjunctive treatment with PI on AHF was superior to conventional medicine alone. It increased the total effective rate (RR = 1.38; 95% CI, 1.22–1.55; p &lt; 0.001) and improved left ventricular ejection fraction [SMD = 0.85; 95% CI (0.62, 1.09); p &lt; 0.001]. Regarding safety, a total of 11.9% (23/194) adverse reactions were observed in the PI group and 9.8% (19/194) adverse reactions in the control group, and there were no significant differences in the incident rate of adverse events between both groups [RR = 1.16; 95% CI (0.66–2.05); p = 0.061]. The outcomes’ evidentiary quality was assessed as “moderate.”ConclusionPI had an adjunctive effect on AHF combined with conventional medicine, and it seemed to be safe and more effective than the conventional medical treatment alone for improving the total clinical effective rate and left ventricular ejection fraction. But further well-designed RCTs are required to confirm the efficacy and safety of XBP in treating AHF due to the poor methodological quality of the included RCTs.Systematic Review Registration:[https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=327636], identifier [CRD42022327636].