bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ekspresi reseptor vitamin D plasenta yang rendah sebagai faktor risiko terjadinya preeklampsia dengan gambaran berat
Authors: Dira I Gede Mahendra Adiguna , Suwiyoga Ketut , Artana Putra I Wayan , Putra I Gede Mega , Manuaba Ida Bagus Gede Fajar , Winata I Gde Sastra , Megadhana I Wayan 
Published: December 2022

Introduction: Preeclampsia is the cause of 10-15% of maternal deaths in Indonesia and occurs in about 2-10% of all pregnancies worldwide. The pathogenesis that underlies the occurrence of preeclampsia is not yet clearly known so that preeclampsia is referred to as a disease of theory. Nutritional factors such as vitamin D also play a role in the development of preeclampsia. This study aims to determine the relationship between vitamin D receptor expression as a risk factor for preeclampsia with severe features.Method: This study used a case-control design conducted in the maternity ward of Sanglah General Hospital, Denpasar from February to August 2020. A sample of 44 subjects was obtained and divided into case groups and control groups. Examination of vitamin D receptors using a central area placenta measuring 2x2 cm which was then examined semi-quantitatively at the Histology Laboratory, Faculty of Medicine, Udayana University.Result: The results were analyzed using the chi square test. There was no significant difference in the characteristics of the two groups. There was a significant relationship between low VDR expression in the placenta and the incidence of preeclampsia with severe features (p-value 0.002; 95% CI 1.96-31.57; OR 7.88).Conclusion: Low VDR placenta expression in pregnant women increases the risk of preeclampsia with a severe picture of 7.88 times greater than high VDR expression. Pendahuluan: Preeklampsia menjadi penyebab 10-15% kematian maternal di Indonesia, dan terjadi pada sekitar 2-10% dari seluruh kehamilan di seluruh dunia. Patogenesis yang mendasari terjadinya preeklampsia sampai saat ini belum jelas diketahui sehingga preeklampsia disebut sebagai disease of theory. Faktor nutrisi seperti vitamin D juga memainkan peran dalam terjadinya preeklampsia. Penelitian ini bertujuan mencari hubungan ekspresi reseptor vitamin D sebagai faktor risiko terjadinya preeklamsia dengan gambaran berat.Metode: Penelitian ini menggunakan desain kasus-kontrol yang dilakukan di Ruang Bersalin RSUP Sanglah Denpasar pada Februari sampai Agustus 2020. Didapatkan sampel sebanyak 44 subyek dan dibagi kedalam kelompok kasus dan kelompok kontrol. Pemeriksaan reseptor vitamin D menggunakan plasenta area sentral ukuran 2x2 cm yang kemudian diperiksa secara semikuantitatif di Laboratorium Histologi Fakultas Kedokteran Universitas Udayana. Hasil dianalisa menggunakan uji chi square.Hasil: Tidak terdapat perbedaan karakteristik yang bermakna pada kedua kelompok. Terdapat hubungan yang bermakna antara ekspresi VDR pada plasenta yang rendah terhadap kejadian preeklamsia dengan gambaran berat (p-value 0.002; IK 95% 1.96-31.57; OR 7.88).SimpulanEkspresi VDR plasenta yang rendah pada ibu hamil meningkatkan risiko terjadinya preeklamsia dengan gambaran berat sebesar 7,88 kali lebih besar dibandingkan ekspresi VDR tinggi.
Serial kasus pneumonia neonatal dengan kemungkinan transmisi vertikal SARS-CoV-2 pada masa kehamilan
Authors: Dewi Ida Ayu Sri Kusuma , Indira Ade Tsarina 
Published: December 2022

Background: The vertical transmission of SARS-CoV-2 from pregnant women to fetuses during pregnancy is still under debate. However, the incidence of COVID-19 in neonates born to mothers with SARS-Cov-2 infection is increasing. Several case reports suspect that the possibility of transmission of SARS-CoV-2 can occur vertically through the placenta. Most neonates with COVID-19 infection experience mild illness, but some develop severe symptoms.Case Report: We report two cases of neonates with Neonatal Pneumonia born to mothers with COVID-19 infection. The first case is a baby born to a mother infected with COVID-19 with placenta previa totalis. The baby was born with severe asphyxia. The second case was a baby born to a mother infected with COVID-19 with premature membrane rupture. The baby experiences respiratory distress after four days of age. An RT-PCR swab examination was performed in both cases, and the results were positive. After intensive care, both babies were discharged in stable condition.Conclusion: The vertical transmission of SARS-CoV-2 is still under debate. Examinations other than nasopharyngeal RT-PCR swabs such as peripheral blood examinations for mother and baby, placenta, umbilical cord, umbilical cord blood, amniotic fluid are needed to support vertical transmission. In this case report, we could only perform the Nasopharyngeal RT-PCR swab test due to various limitations. Latar Belakang: Transmisi vertical SARS-CoV-2 dari ibu hamil ke janin selama masa kehamilan masih dalam perdebatan. Namun Angka kejadian COVID-19 pada neonatus yang lahir dari ibu dengan infeksi SARS-Cov-2 tersebut kian meningkat. Beberapa laporan kasus mencurigai bahwa kemungkinan transmisi dari SARS-CoV-2 dapat terjadi secara vertikal melalui plasenta. Sebagian besar neonatus dengan infeksi COVID-19 ini mengalami gejala ringan, namun beberapa berkembang menjadi berat. Laporan Kasus: Pada laporan ini, kami melaporkan dua kasus neonatus dengan pneumonia neonatal yang lahir dari ibu dengan infeksi COVID-19. Kasus pertama merupakan bayi yang lahir dari ibu yang terinfeksi COVID-19 dengan plasenta previa totalis, bayi lahir dengan asfiksia berat. Kasus kedua merupakan bayi yang lahir dari ibu yang terinfeksi COVID-19 dengan ketuban pecah dini (KPD), bayi mengalami distress napas setelah usia 4 hari. Pada kedua kasus ini dilakukan pemeriksaan swab RT-PCR dan mendapatkan hasil positif. Setelah dilakukan perawatan intensif, kedua bayi dipulangkan dengan kondisi stabil. Kesimpulan: Transmisi vertikal SARS-CoV-2 masih dalam perdebatan. Pemeriksaan selain swab RT-PCR nasofaring seperti pemeriksaan darah perifer pada ibu dan bayi, plasenta, tali pusat, darah tali pusat, cairanan amnion dibutuhkan untuk menunjang adanya suatu transmisi vertikal. Pada laporan kasus ini kami hanya dapat melakukan tes swab RT-PCR nasofaring dikarenakan keterbatasan pemeriksaan.
Incontinentia pigmenti in neonate: a case report
Authors: Wangsa Putu Gde Hari , Rusyati Luh Made Mas , Karmila I Gusti Ayu Agung Dwi , Karna Ni Luh Putu Ratih Vibriyanti , Komalasari Ketut Wida , Laksmi Made Hermina 
Published: December 2022

Background: Incontinentia pigmenti (IP) is a rare X-linked dominant inherited genodermatosis that occurs almost in females and is usually accompanied by other ectodermal tissue diseases such as the central nervous system, eyes, hair, nails, teeth and skeletal system. This case report aims to enhance understanding of incontinentia pigmenti and provide appropriate treatment to patients and proper education to families.
Case report: A 3-days-od baby girl was consulted by the Pediatric department with complaints of blisters and erythematous rashes on almost her entire body with the Blaschko line distribution. The nails on the right and left big toes appeared inward. No history of fever and seizure. No family had similar complaints. There were no eye and nerve abnormalities involved. She treated with hydrocortisone 1% cream every 12 hours on erythematous papules and vesicles, open compresses with 0.9% NaCl every 8 hours for 10-15 minutes on lesions with yellowish crusts. Thus, the patient diagnosed with incontinentia pigmenti.
Conclusion: The diagnosis of incontinentia pigmenti is based on history and physical examination. This case is very rare, so the family needs to understand the course of this disease. Appropriate management and education can prevent secondary infection.
Platelet-rich plasma (PRP) on orthopedic clinical daily practice: a literature review
Authors: Gunawan Anthony , Anak Agung Ngurah Ronny Kesuma  , I Komang Agus Krisna Saputra¬¬  , I Komang Mahendra Laksana  
Published: December 2022

The use of PRP (platelet-rich plasma) is beneficial and even more important in the future. The most common indications were tendon damage (77%), osteoarthritis (68%), muscle damage (57%) and cartilage damage (51%). It is a purified autologous blood product with a higher platelet concentration than whole blood. It is rich in various cytokines and growth factors and has been shown to initiate and enhance healing by stimulating cell migration, cell proliferation, angiogenesis, and matrix synthesis. In rotator cuff injury, PRP injection led to significant long-term pain relief but not in functional improvements. In Osteoarthritis, PRP injection is associated with long-term pain relief and function improvements. PRP injection has a better outcome in VAS (visual analog scale) and DASH (The Disabilities of the Arm, Shoulder and Hand) scores in elbow ulnar collateral ligament pathologies, including lateral elbow epicondylitis. In medial epicondylitis, a paucity of studies causing therapeutic modality for PRP has not yet been established. In acute muscle injury, PRP used has no differences in imaging, pain, ROM (range of motion), muscle strength, and muscle function. In Achilles Tendinopathy, PRP injection has been associated with improvement in VAS, but no difference in VISA-A (The Victorian Institute of Sports Assesment – Achilles Questionnaire) score. However, the majority of published literature is secondary and tertiary evidence. Future studies could provide important information about the optimal concentrations of growth factors, platelets and leukocytes required for the desired effect in many specific tissues, as well as the appropriate method of administration and timing of drug application.
Penetrating ocular injury due to fish hook accident: A case report
Authors: Dewi Nyoman Tarita , Widyasari Putu Rima Adilitha , Sakti Fazella Kirara , Kartiningsih Ida Ayu Putri 
Published: December 2022

Introduction: Open globe trauma is caused by sharp objects (lacerations) or blunt objects (ruptures). Lacerations can be divided into three parts: penetrating wound, intraocular foreign body (IOFB), and perforating wounds. One of the ocular laceration trauma that needs to be aware of is the penetration of fishing hooks. There are two important aspects of injuries due to fishing hooks: intraocular foreign bodies and infections.Case description: The patient of a 4-year-old girl with a chief complaint left eye was exposed to a fishing hook approximately 3 hours before coming to the hospital. Ophthalmological examination was obtained visual acuity on the right eye fixes and follow the object. Examination of the anterior segment of the right eye was found corneal edema, penetrating injury due to fish hook direction at nine o'clock. The fish hook was stick on the entire thickness of the cornea. Then we also found iris trauma and opacity in the lens. The patient was diagnosed with traumatic cataracts with ocular iridolysis dextra. Initial therapy is tobroson eye drop 1 drop every 3 hours, cefadroxil syrup three times a day, and methylprednisolone 3x1/2 tablets. The patient was advised to undergo surgery.Conclusion: Initial management should be quick and careful to aggravate the trauma. Adequate eye protection and supervision are necessary to prevent fishing hook trauma, especially children.
Faktor-faktor yang berhubungan dengan kepuasan pasien di instalasi rawat jalan Rumah Sakit Tingkat IV Lanud Sam Ratulangi Manado pada masa pandemi covid-19
Authors: Pangemanan Andrew Christian , Rampengan Starry Homenta , Sumampouw Oksfriani Julfri , Manampiring Aaltje Ellen 
Published: December 2022

Latar belakang: Kepuasan pasien dicapai apabila penerima pelayanan memperoleh pelayanan sesuai dengan yang dibutuhkan dan diharapkan. Pandemi Coovid-19 menyebabkan penurunan angka kunjungan pasien, hal ini terjadi karena terdapat alur proses pelayanan kesehatan yang berubah, pembatasan jumlah pasien, serta diterapkannya langkah pencegahan standar, identifikasi awal dan pengendalian sumber virus. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang berhubungan dengan kepuasan pasien di instalasi rawat jalan Rumah Sakit Tingkat IV Lanud Sam Ratulangi Manado pada masa pandemi Covid-19. Metode: Penelitian ini merupakan penelitian kuantitatif dengan pendekatan studi potong lintang. Penelitian ini dilaksanakan di Rumah Sakit Tingkat IV Lanud Sam Ratulangi Manado pada November-Desember 2021. Sampel penelitian berjumlah 334 pasien. Variabel bebas dari peneitian ini yaitu kesehatan fisik dan psikis pasien, kompetensi staf medis dan fasilitas rumah sakit. Variabel terikat dari penelitian ini adalah kepuasan pasien. Data hasil penelitian dianalisis secara univariat, bivariat, dan multivariat. Hasil: Hasil penelitian menunjukkan bahwa responden paling banyak berjenis kelamin laki-laki (52,69%), mayoritas berumur 36-45 tahun (37,72%), pekerjaan terbanyak swasta (35,33%) dan tingkat pendidikan terbanyak SMA/sederajat (46,41%). Hasil uji korelasi pearson ditemukan bahwa faktor kesehatan fisik dan psikis, kompetensi staf medis dan fasilitas rumah sakit nilai p<0,05. Berdasarkan uji regresi linier berganda ditemukan faktor yang paling mempengaruhi kepuasan pasien adalah fasilitas rumah sakit dengan nilai standardized coefficients beta sebesar 0,314. Kesimpulan: Faktor kesehatan fisik dan psikis, kompetensi staf medis, dan fasilitas rumah sakit berhubungan dengan kepuasan pasien di instalasi rawat jalan Rumah Sakit Tingkat IV Lanud Sam Ratulangi Manado pada masa pandemi Covid-19. Fasilitas rumah sakit merupakan faktor yang dominan berpengaruh terhadap kepuasan pasien
Moluskum kontagiosum dengan human immunodeficiency virus stadium IV yang diterapi dengan KOH 20%
Authors: Hostiadi Michael , Indira I Gusti Ayu Agung Elis , Ni Made Dwi Puspawati  , Ketut Wida Komalasari  
Published: December 2022

Background: The prevalence of molluscum contagiosum (MC) was found to increase in the HIV population with a prevalence of 5-18%. Persistent molluscum lesions gradually increase in size. Some develop into giant, tumor-like, nodular lesions that can exceed 1 cm in diameter and cause esthetic defects in HIV-positive patients. Conventional treatment is usually not effective enough and requires additional therapy in immunocompromised cases.
Case: A 31-year-old woman with stage IV HIV had the main complaint of a skin-colored rash near the genital area. Venereological examination found multiple papules with smooth, shiny surfaces with central umbilication discrete configuration and localized distribution. The molluscum body comes out after being squeezed. The treatment given is 20% potassium hydroxide spots on MC lesions every 24 hours topically. Two weeks after therapy was given, no new lesions were found without any side effects.
Conclusion: Administration of 20% potassium hydroxide can be considered an MC treatment option in HIV patient with minimal side effects and is easy to use.

Latar Belakang: Prevalensi moluskum kontagiosum (MK) didapatkan meningkat pada populasi human immunodeficiency virus (HIV) dengan prevalensi 5-18%. Lesi moluskum persisten yang secara bertahap bertambah besar, beberapa berkembang menjadi raksasa, seperti tumor, lesi nodular yang dapat melebihi diameter 1cm, dan dapat menyebabkan kecacatan secara estetik sering ditemui pada pasien dengan HIV positif. Pengobatan konvensional biasanya tidak cukup ampuh dan membutuhkan tambahan terapi lainnya pada kasus imunokompromais.
Kasus: Seorang perempuan usia 31 tahun, HIV positif stadium IV dengan keluhan utama berupa bintil-bintil bewarna serupa kulit di dekat area genital, bila ditekan keluar bintik putih seperti nasi. Pemeriksaan venereologis ditemukan papul multipel permukaan licin berkilat dengan umbilikasi sentral konfigurasi diskret dengan distribusi lokalisata. Penatalaksanaan yang diberikan adalah tutul kalium hidroksida (KOH) 20% pada lesi MK setiap 24 jam topikal. Dua minggu setelah terapi diberikan tidak ditemukan adanya lesi baru dan tanpa adanya efek samping.
Simpulan: Pemberian KOH 20% dapat dipertimbangkan sebagai pilihan terapi MK pada HIV dengan efek sampung minimal dan mudah digunakan.
Tetraparese spastik akibat schwannoma servikal: sebuah laporan kasus
Authors: Pinzon Rizaldy Taslim , Sinta Shakuntala Gusti Agung , Veronica Vanessa 
Published: December 2022

Introduction: Schwannoma is a benign nerve sheath tumor that occurs more frequently in the peripheral nervous system than in the central nervous system. Spinal schwannomas are most frequently found in the thoracic or lumbar regions but are uncommon in the cervical region. This paper describes a cervical schwannoma that is associated with spastic tetraparesis.
Case Presentation: A 50-year-old man presented with the primary complaint of having difficulty moving his upper and lower limbs. The patient is fully conscious and has a temperature of 36.2°C, a respiratory rate of 22 breaths per minute, and a pulse rate of 108 beats per minute. Neurological evaluation revealed bilaterally diminished strength in the superior and inferior extremities. Cervical magnetic resonance imaging (MRI) with and without contrast revealed a grade 2 hernia nucleus pulposus (HNP) and an extramedullary-intradural mass in the anterior cervical vertebral canal region between C5 and C7, compressing and obliterating the cerebrospinal fluid spaces. A laminectomy was performed, and an intradural tumor mass in the C5-C7 region was obtained.
Conclusion: Schwannomas, although rare, can cause spastic tetraparesis if they compress the cervical spinal cord.

Latar Belakang: Schwannoma adalah tumor selubung saraf jinak yang lebih sering terjadi di luar sistem saraf pusat. Schwannoma spinal dapat terjadi di regio thorakal atau lumbar, namun jarang terjadi pada regio servikal. Studi ini melaporkan schwannoma servikal yang menyebabkan tetraparese spastik.
Presentasi Kasus: Seorang laki-laki umur 50 tahun datang dengan keluhan utama kedua anggota gerak atas dan bawah sulit digerakkan. Pasien sadar penuh dengan suhu 36,2°C, laju respirasi 22 kali per menit, nadi 108 kali per menit. Pemeriksaan neurologis menunjukkan adanya penurunan kekuatan ekstremitas superior dan ekstremitas inferior bilateral. Magnetic resonance imaging (MRI) servikal dengan kontras dan tanpa kontras menunjukkan hernia nucleus pulposus (HNP) grade 2 dan massa ekstramedular-intradural pada regio kanalis vertebra servical anterior setinggi C5-C7 yang menyebabkan kompresi dan obliterasi ruang cairan serebrospinal. Dilakukan laminektomi dan didapatkan massa tumor intradural C5-C7.
Kesimpulan: Schwannoma, walaupun jarang, dapat menyebabkan tetraparese spastik jika menekan medula spinalis servikal.
Anaphylactic reaction: lesson learned from three cases
Authors: Bunga Datu William , Raya Katinda Emita , Suprayogi Andrew 
Published: December 2022

Background: An anaphylactic reaction is an emergency that can be life-threatening if not recognized immediately. Signs and symptoms that appear vary from mild to severe. After knowing that it is an anaphylactic reaction, it needs immediate action and special attention, especially from general practitioners who work in the emergency unit.
Case presentation: In this scientific publication, three cases will be presented, all of which were found in the emergency room at Cikarang Medika Hospital, Bekasi. These cases of anaphylaxis vary in the onset of signs and symptoms, clinical manifestation, allergen, degree of severity, and therapeutic response. However, in these three cases, the initial management, which was an emergency, was the same for each patient, and all cases occurred at home; thus, education on anaphylaxis in the general community is vital, especially for the patients and their families.
Conclusion: As a physician who works in the emergency room is essential to know how to quickly recognize the signs and symptoms of an anaphylactic reaction and carry out treatment as soon as possible so that patients can be helped. The first line treatment is Epinephrine and other treatment may follow after the first line has been given. It is essential that the public needs to know about the occurrence, the cause or trigger, and first aid (what they should do in the event of an anaphylactic reaction).
Botox injection for anal fissure management: case report
Authors: Antara Gede Eka Rusdi 
Published: December 2022

Introduction: Anal fissure is shallow tear in the anoderm distal to dentate line which is considered most common proctologic condition. Anal fissure is generally located in the posterior midline. The symptoms include anal pain, spasm, and/or bleeding during defecation1. The pain can be so intense as to induce the patient to avoid defecation with consequent hardening of the feces and exacerbation of the problem2. Management of the anal fissure is improving diet and defecation habit, medical therapy and surgical therapy. The goal of medical treatment for chronic anal fissure is to temporarily reduce pressure of the anal canal to facilitate the healing of the fissure (“reversible sphincterotomy”), thereby reducing muscle tone. Intrasphincteric Botulinum Toxin A injection seems to be a reliable option.
Case reports: two male patients were diagnosed with anal fissures, the patients complained of pain and spasm. They were treated with botulinum toxin type A (100 unit AllergenÒ), injected into three sites of the internal sphincter at 2, 5 and 8 o’clock. The symptoms relieved and the anal fissure healed within one month. There was no sign of relapse or incontinence during 12 months of follow-up.
Conclusion: Botulinum toxin therapy can be considered as efficacious, effective and safe treatment for anal fissures.

Keywords: anal fissure, botox, botulinum toxin, intrasphincteric
Tatalaksana laser CO2 pada hiperplasia kelenjar sebasea: laporan kasus
Authors: Sari Maylita , Fadila Arisia , Muhammad Yulianto Listiawan  , Bagus Haryo Kusumaputra  , Irmadita Citrashanty  
Published: December 2022

Background: Sebaceous gland hyperplasia is a benign skin disorder in the form of macules or papules which are generally < 1 mm in size, skin color or yellowish at the mouth of the pilosebaceous gland follicle.1 This disorder can cause cosmetic morbidity and psychosocial impacts for patients. There are various treatment modalities for sebaceous gland hyperplasia associated with the risk of pain, depigmentation, bleeding during the procedure, scarring, and recurrence. CO2 laser is one of the therapeutic approaches that are considered effective and safe.
Case: A female patient came with the chief complaint of lumpy skin-colored lumps on the back of the ear to the left neck that had increased in number and had not been painful since about 4 years ago. Histopathological examination was performed on the lump showing hyperplasia of the sebaceous glands. The patient was treated with 2 CO2 Laser sessions with an even skin surface result. Observations made within 9 months after the procedure did not reveal any recurrence of the lesion.
Conclusion: CO2 laser can be an effective and safe alternative therapy for sebaceous gland hyperplasia.

Latar Belakang: Hiperplasia kelenjar sebasea adalah kelainan jinak kulit berupa makula atau papula yang umumnya berukuran < 1 mm sewarna kulit atau kekuningan di muara folikel kelenjar pilosebasea.1 Kelainan ini dapat menimbulkan morbiditas kosmetik dan dampak psikososial bagi pasien. Terdapat berbagai modalitas tatalaksana hiperplasia kelenjar sebasea yang berhubungan dengan risiko nyeri, depigmentasi, perdarahan selama prosedur, skar, hingga kekambuhan. Laser CO2 merupakan salah satu pendekatan terapi yang dianggap efektif dan aman.
Kasus: Pasien wanita datang dengan keluhan utama benjolan bergerombol sewarna kulit pada telinga bagian belakang hingga leher kiri yang bertambah banyak dan tidak nyeri sejak kurang lebih 4 tahun yang lalu. Pemeriksaan histopatologi dilakukan pada benjolan menunjukkan hasil hiperplasia kelenjar sebasea. Pasien diterapi dengan 2 sesi Laser CO2 dengan hasil permukaan kulit rata. Observasi yang dilakukan dalam 9 bulan paska tindakan tidak didapatkan rekurensi pada lesi.
Simpulan: Laser CO2 dapat menjadi alternatif terapi pada hiperplasia kelenjar sebasea yang efektif dan aman.