bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Machine Learning Algorithm for Predicting the Risk of Developing to M1b Stage of Patients With Germ Cell Testicular Cancer
Authors: Ding Li , Wang Kun , Zhang Chi , Zhang Yang , Wang Kanlirong , Li Wang , Wang Junqi 
Published: June 2022

Objective:Distant metastasis other than non-regional lymph nodes and lung (i.e., M1b stage) significantly contributes to the poor survival prognosis of patients with germ cell testicular cancer (GCTC). The aim of this study was to develop a machine learning (ML) algorithm model to predict the risk of patients with GCTC developing the M1b stage, which can be used to assist in early intervention of patients.MethodsThe clinical and pathological data of patients with GCTC were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Combing the patient's characteristic variables, we applied six machine learning (ML) algorithms to develop the predictive models, including logistic regression(LR), eXtreme Gradient Boosting (XGBoost), light Gradient Boosting Machine (lightGBM), random forest (RF), multilayer perceptron (MLP), and k-nearest neighbor (kNN). Model performances were evaluated by 10-fold cross-receiver operating characteristic (ROC) curves, which calculated the area under the curve (AUC) of models for predictive accuracy. A total of 54 patients from our own center (October 2006 to June 2021) were collected as the external validation cohort.ResultsA total of 4,323 patients eligible for inclusion were screened for enrollment from the SEER database, of which 178 (4.12%) developing M1b stage. Multivariate logistic regression showed that lymph node dissection (LND), T stage, N stage, lung metastases, and distant lymph node metastases were the independent predictors of developing M1b stage risk. The models based on both the XGBoost and RF algorithms showed stable and efficient prediction performance in the training and external validation groups.ConclusionS-stage is not an independent factor for predicting the risk of developing the M1b stage of patients with GCTC. The ML models based on both XGBoost and RF algorithms have high predictive effectiveness and may be used to predict the risk of developing the M1b stage of patients with GCTC, which is of promising value in clinical decision-making. Models still need to be tested with a larger sample of real-world data.
Hip Abductor Muscle Fatigue Induces Different Strategies During Disrupted Postural Control
Authors: Dury Jeanne , Ravier Gilles , Michel Fabrice 
Published: June 2022

BackgroundAnkle sprain is one of the most common injuries in sport, and hip abductor muscle weakness has recently been reported as a predisposing factor. Currently, the influence of hip abductor muscle fatigue on ankle joint control has not been elucidated during an ankle disturbed balance exercise. This study aimed to determine the influence of hip abductor muscle fatigue on ankle joint control during a disturbed balance task, and to consider inter-individual variability in the kinematic and neuromuscular reorganizations implemented.MethodsTwenty-six healthy subjects (13 males; 13 females) performed a unipedal postural balance task with eyes closed before and after a fatiguing exercise (up to a 50% decrease in strength) of the hip abductor muscles. Subjects completed balance task while equipped with an ankle destabilization device that allows inversion/eversion movements. Electromyographic (EMG) activity of the gastrocnemius lateralis (GastL), peroneus longus (PL) and brevis, tibialis anterior, and gluteus medius were recorded during task. Kinematics (e.g., frontal foot angulation) of the ankle complex were determined using inertial measurement units.ResultsIn the overall group, no significant time, sex or interaction effect was observed for kinematic and EMG variables. However, when considering individual responses to hip fatigue, 14 subjects decreased the standard deviation of frontal angulation (−30%) suggesting enhancement of ankle joint control, while 12 subjects increased it (+46%). Normalized EMG for PL and GastL muscles changed with fatigue for both these groups. However, variations were significantly different between groups (p = 0.027 for PL and p = 0.006 for GastL). Indeed, the contribution of ankle muscles increased for the enhanced-stability group while no change for the impaired-stability group.ConclusionThese results highlight that subject adopt different neuromuscular and kinematic ankle strategies to control ankle destabilization in response to hip abductor muscle fatigue. Frontal foot angulation variability seemed to be a valuable marker to detect the type of strategy employed. The strategy adopted by the impaired-stability group might have important implications when analyzing risk factors for ankle sprains. Further studies should consider individual responses to fatigue, to understand which factor could predispose athletes to use of one or other strategy.
Environmental LCA of Precision Agriculture for Stone Fruit Production
Authors: Núñez-Cárdenas Pablo , Diezma Belén , San Miguel Guillermo , Valero Constantino , Correa Eva C. 
Published: June 2022

Precision agriculture is a concept that encompasses various technologies aimed at optimizing the management of agricultural activities. The main aim of this investigation is to evaluate the environmental and economic performance of precision agriculture practices on the production of a stone fruit crop (nectarine) using a life cycle approach and to consider a cradle-to-farm gate scope. The results have been compared against the traditional uniform application (UA). The analysis considers five impact categories, including climate change, photochemical ozone formation, acidification, eutrophication, and water use. The foreground inventory data was provided by a local producer in Southern Spain, and the background information was sourced from commercial Life Cycle Inventory (LCI) databases. The results show that the manufacturing of crop inputs (mainly fertilizers, but also crop management inputs) is responsible for most of the damage generated in all the impact categories, except for water use. The reduced input requirements associated with the application of VA techniques resulted in significantly lower economic costs and environmental savings throughout the life cycle of the production system, which ranged on average between 12–26%.
Light Scattering and Turbidimetry Techniques for the Characterization of Nanoparticles and Nanostructured Networks
Authors: Anzini Pietro , Redoglio Daniele , Rocco Mattia , Masciocchi Norberto , Ferri Fabio 
Published: June 2022

Light scattering and turbidimetry techniques are classical tools for characterizing the dynamics and structure of single nanoparticles or nanostructured networks. They work by analyzing, as a function of time (Dynamic Light Scattering, DLS) or angles (Static Light Scattering, SLS), the light scattered by a sample, or measuring, as a function of the wavelength, the intensity scattered over the entire solid angle when the sample is illuminated with white light (Multi Wavelength Turbidimetry, MWT). Light scattering methods probe different length scales, in the ranges of ~5–500 nm (DLS), or ~0.1–5 μm (Wide Angle SLS), or ~1–100 μm (Low Angle SLS), and some of them can be operated in a time-resolved mode, with the possibility of characterizing not only stationary, but also aggregating, polymerizing, or self-assembling samples. Thus, the combined use of these techniques represents a powerful approach for studying systems characterized by very different length scales. In this work, we will review some typical applications of these methods, ranging from the field of colloidal fractal aggregation to the polymerization of biologic networks made of randomly entangled nanosized fibers. We will also discuss the opportunity of combining together different scattering techniques, emphasizing the advantages of a global analysis with respect to single-methods data processing.
How Does Microbiota Form Rheumatic Diseases? Part 1
Authors: Рудой А.С. 
Published: June 2022

В кишечнике человека обитает чрезвычайно разнообразное и обильное микробное сообщество, которое корректирует и даже модулирует многие процессы, связанные со здоровьем. «Интерфейсы» слизистой оболочки являются особенно активными участками взаимодействия микроорганизмов и хозяев. Возрастающее понимание характерного состава и функции микробиоты кишечника выявило, что она участвует не только в поддержании целостности слизистой оболочки, но затрагивает и гомеостаз системы иммунитета с формированием как локальных, так и системных иммунных реакций. В представленном обзоре рассмотрена роль нарушений устойчивого состояния и взаимодействия «хозяин – микроорганизм», которые могут потенциально влиять на развитие и прогрессирование ревматических заболеваний. В заключение будут рассмотрены вопросы новых терапевтических целей коррекции микробиоты.
The human guts have a tremendously diverse and abundant microbial community that corrects and even modulates many health-related processes. The “interfaces” of the intestinal mucosa are particularly active sites of interaction between microorganisms and hosts. The growing understanding of the typical composition and function of the gut microbiota has revealed that it is involved not only in maintaining the integrity of the mucous membrane, but also affects the homeostasis of the immune system with the formation of both local and systemic immune responses. In this review, there is considered the host–microorganism interplay, which can potentially affect the development and progression of rheumatic diseases. In conclusion, the issues of new therapeutic goals of microbiota correction will be considered.
[Reseña] Primeros contactos con la lectura. Leer sin saber leer
Authors: García Garnica Marina de los Ángeles 
Published: June 2022

M. Clemente Linuesa y E. Ramírez Orellana. Primeros contactos con la lectura. Leer sin saber leer. Salamanca: Fundación Germán Sánchez Ruipérez, 2008, 135 págs. ISBN: 978-84-89384-72-9.
Vivimos en una sociedad en la que la imagen está sobrevalorada, aún así, el texto y la lectura siguen siendo la principal forma de acceso al conocimiento, constituyendo una herramienta imprescindible en el desarrollo personal y social de los individuos.
Presentación. Entornos Virtuales de Aprendizaje en Iberoamérica
Authors: Díaz Eduardo , Asenjo Joaquín 
Published: June 2022

Las tecnologías de la información y la comunicación aplicadas a la educación y a la creación de entornos virtuales de aprendizaje permiten romper las barreras espacio temporales existentes en las aulas tradicionales al posibilitar una interacción abierta a las dinámicas del mundo actual. El potencial y la importancia que en nuestra región toman estos espacios han impulsado a la rie a dedicar un número monográfico a los sistemas de gestión del aprendizaje en la enseñanza en entornos virtuales, que técnicamente se han denominado, según sus acrónimos ingleses, lms (learning managment system) o vle (virtual learning environment), en español entorno virtual de aprendizaje (eva).
El número ha reunido un conjunto de contribuciones que pretenden ser aproximaciones conceptuales sobre su pedagogía, su didáctica, con estudios de caso de algunas experiencias iberoamericanas y con trabajos sobre los nuevos entornos por los que actualmente se transita. Se trata, entonces, de un monográfico tan intenso en el tratamiento de temas alrededor de la educación formal y la corporativa –en línea o en formato semipresencial– como diverso en sus contribuciones.
[Reseña] 10 criterios para educar en valores con El Quijote
Authors: Belando-Montoro María Remedios 
Published: June 2022

Valentín Martínez-Otero (2016): 10 criterios para educar en valores con El Quijote. Madrid, CCS, 81 páginas.
10 Criterios para educar en valores con El Quijote forma parte de la colección 10 Criterios de la editorial CCS en la que se abordan una serie de temas educativos actuales de un modo sencillo y claro, pero sin perder por ello la solidez derivada de la formación y experiencia especializadas de los diversos autores. Cada uno de los libros está enfocado al logro de una serie de objetivos prácticos. En este caso, la temática es la educación en valores y su autor es Valentín Martínez-Otero, doctor en Psicología, doctor en Pedagogía y profesor-investigador en la Universidad Complutense de Madrid.
papel do movimento feminista na radicalização da democracia
Authors: Kozicki Katya , Bonatto Marina 
Published: June 2022

O objetivo do presente trabalho é verificar a possibilidade da construção de um projeto democrático radical feminista. Longe de ser um conceito estático e universal, a democracia pode ser concebida de diferentes formas e analisada de acordo com diferentes perspectivas. O trabalho assume a democracia liberal como modelo hegemônico na modernidade para destacar que esse modelo, por sua vez, tem se mostrado insuficiente para abarcar a pluralidade inerente a vida em sociedade e garantir direitos a todas e a todos. Considerando a necessidade de extensão dos princípios básicos da democracia liberal, quais sejam, liberdade e igualdade, o trabalho parte de uma premissa normativa para demonstrar a potencialidade do modelo de democracia radical nesse sentido. Adota-se como marco teórico a ideia de democracia radical de Chantal Mouffe. Partindo de uma premissa normativa de radicalização da democracia, pretende-se demonstrar as contribuições das teorias políticas e democráticas feministas para esse projeto, bem como o papel das minorias, marcadamente as de gênero. É em virtude da necessidade de construção de uma ordem mais democrática e menos excludente que se faz necessário afastar perspectivas essencialistas da democracia e radicalizá-la.
Neuraxial anesthesia for extended endoscopic urological procedure in a patient with MELAS syndrome: a case report
Authors: Ababneh Muaweih , Shehab Refaat Al- , Suleiman Aiman , Suleiman Aiman 
Published: June 2022

We present a case of a 36-years-old male patient with MELAS syndrome (Mitochondrial myopathy, Encephalopathy, Lactic acidosis, and Stroke-like episodes) underwent ureteroscopy, lithotripsy and indwelling double J stent exchange under neuraxial anesthesia. MELAS is a progressive mitochondrial myopathy that results in defects in respiratory enzyme complexes I and IV, which lead to defects in aerobic metabolism, thus endangering high-energy-dependent organs. MELAS causes a wide range of physiologic changes that present a variety of challenges to the anesthetists. In this case, we managed our patient safely with spinal/epidural anesthesia without any major complications.
Abbreviations: MELAS - Mitochondrial myopathy, Encephalopathy, Lactic acidosis, and Stroke; MM - Mitochondrial myopathies; ATP - Adenosine triphosphate; ESWL - Extracorporeal shock wave lithotripsy; CPAP - Continuous positive airway pressure
Key words: MELAS; Acidosis, Lactic / genetics; Anesthetic management; Mitochondrial myopathies; Neuraxial anesthesia: Genetics.
Citation: Ababneh M, Al-Shehab R, Suleiman A. Neuraxial anesthesia for extended endoscopic urological procedure in a patient with MELAS syndrome: a case report. Anaesth. pain intensive care 2022;26(3):419-422. DOI: 10.35975/apic.v26i3.1754
Received: January 23, 2022; Reviewed: May 05, 2022; Accepted: May 30, 2022
A randomized, controlled study to evaluate the effect of parenteral glutamine on the reduction of infection related morbidity in burn patients in ICU
Authors: Eskandr Ashraf M. , Attalla Hatem A. , Massoud Mona E. , Aiad Alaa-Eldin A. 
Published: June 2022

Background: Burn patients are characterized by alterations within the immune system, increased exposure to infectious complications, sepsis, and potentially organ failure and death. Glutamine supplementation to parenteral nutrition has been proven to be related to improved clinical outcomes in trauma patients. We studied the effect of glutamine supplementation on infection and clinical outcomes among burn patients.
Methodology: Sixty burn patients were randomly divided into two equal groups. Group I received 0.5 gm/kg/day glutamine infusion as a part of parenteral nutrition for seven days after ICU admission. Group II received an intravenous placebo by continuous infusion (24 h/day). The primary outcome was the presence of infection assessed by the wound culture over a 15-days period. The secondary outcomes were: blood culture, WBCs count, serum C-reactive protein (CRP) and procalcitonin, sequential organ failure assessment (SOFA) score, and length of stay within the intensive care unit.
Results: The results showed that the incidence of positive wound culture was considerably reduced within the glutamine group, e.g., 6 (10%) patients) vs. control 19 (33%) patients; P < 0.001). The incidence of positive blood culture was significantly reduced within the study group (1 case) vs. control (9 cases; P = 0.006). In addition, the WBC, serum CRP and procalcitonin were better; and the SOFA score and the ICU-stay were reduced within the glutamine group vs. the control group.
Conclusion: The present results prove that IV glutamine supplementation in adult burn patients can reduce the impact of infectious morbidity and improve the clinical outcome.
Ethical committee approval: 19/5/2019 ANETS 4
Trial registration: www.clinicaltrials.gov No. NCT05140772
Abbreviations: ICU - intensive care unit; SOFA - Sequential Organ Failure Assessment; CRP - C-reactive protein; GFR- glomerular filtration rate; TBSA - total body surface area; BMI – Body mass index
Key words: Glutamine; Infection; Burn; ICU; Mortality
Citation: Eskandr AM, Attalla HA, Massoud ME, Alaa-Eldin A. Aiad AEA. A randomized, controlled study to evaluate the effect of parenteral glutamine on the reduction of infection related morbidity in burn patients in ICU. Anaesth. pain intensive care 2022;26(2):318-325; DOI: 10.35975/apic.v26i3.1898
Received: December 24. 2021, Reviewed: January 18, 2022, Accepted: January 29, 2022
Comparison of normal saline and balanced salt solution as a maintenance fluid on acids-base and electrolyte status in traumatic brain injury patients; a prospective randomized double-blind study
Authors: . Shephali , Singh Yashpal , Mishra Manjaree , Sachan Sumit , Pathak Naman M. , Shankar Ravi 
Published: June 2022

Background & objective: Normal saline is the most commonly used fluid in traumatic brain injury (TBI) patients both in resuscitation and maintenance since long time but associated with hyperchloremic metabolic acidosis. Balanced salt solutions (BSS) are recently developed with favorable outcome in resuscitation and intraoperative as a maintenance fluid. We compared normal saline and BSS as maintenance fluids in TBI patients admitted to intensive care unit.
Methodology: After institutional ethical committee approval and written informed consent from patients’ relatives, 100 patients who meet inclusion criteria were randomly divided into two equal groups; Group NS: to receive normal saline as a maintenance fluids and Group BSS: to receive BSS as a maintenance fluid. Data of serum electrolyte and acid base status were collected on day 1, 3, 5, 7 and 14. Patient outcome was evaluated on day-8. Data was analyzed with appropriate statistical tests. The P < 0.05 indicated that the difference was significant.
Results: In both groups pH gradually increased over time and was more alkaline in normal saline group. Base excess was comparable between two groups. In normal saline group, serum sodium and chloride increased gradually and reached on the higher side on day-14, while potassium level dropped to a lower side. Twenty-eight days mortality was more in Group NS than the Group BSS.
Conclusion: Balanced salt solution causes lesser alterations in acid base and electrolyte status than the normal saline and is associated with more favorable outcome.
Abbreviations: TBI - Traumatic brain injury; BBB - Blood brain barrier; BSS - Balanced salt solution; ABG - Arterial blood gas analysis; GCS - Glasgow Comma Scale; RFT’s - Renal function tests; BE - Base excess
Key words: Ringer's lactate; Sodium Chloride / pharmacology; Balanced salt solution; Double-Blind Method; Humans; Hydrogen-Ion Concentration; Isotonic Solutions / pharmacology; Potassium / blood
Citation: Shephali, Singh Y, Mishra M, Sachan S, Pathak NM, Shankar R. Comparison of normal saline and balanced salt solution as a maintenance fluid on acids-base and electrolyte status in traumatic brain injury patients; a prospective randomized double-blind study. Anaesth. pain intensive care 2022;26(3):326-331.
DOI: 10.35975/apic.v26i3.1899
Received: December 18, 2021; Reviewed: January 25, 2022; Accepted: February 02, 2022
Pneumothorax in COVID-19 patients on non-invasive ventilation: a case series
Authors: Lakhanpal Mahima , Yadav Isha , Aggarwal Ankita , Kumar Ritesh 
Published: June 2022

COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the disease mainly affects the lungs. A rare complication reported in these patients has been pneumothorax, whether spontaneous or iatrogenic in ventilated patients. Sudden desaturation or acute deterioration in clinical conditions should immediately raise a suspicion of pneumothorax, and the clinicians must take appropriate measures without any delay.
We present a series of 7 cases of COVID-19 admitted to our ICU who developed primary spontaneous pneumothorax. All these patients were on non-invasive ventilation (NIV). They did not have any history of underlying lung disease before the existing ailment, and all of them were non-smokers.
Abbreviations: SARS-CoV-2 - acute respiratory syndrome coronavirus-2; NIV - non-invasive ventilation; ARDS - acute respiratory distress syndrome; COVID – coronavirus disease; RT-PCR - Reverse Transcription Polymerase Chain Reaction test; ROSC - return of spontaneous circulation; Pplateau – plateu pressure
Key words: COVID-19; Pneumothorax; Non-invasive ventilation; NIV
Citation: Yadav I, Lakhanpal M, Aggarwal A, Kumar R. Pneumothorax in COVID-19 patients on non-invasive ventilation: a case series. Anaesth. pain intensive care 2022;26(3):410-415. DOI: 10.35975/apic.v26i3.1905
Received: April 19, 2022; Reviewed: April 22, 2022; Accepted: April 24, 2022
The impact of vaccination on stress level of trainee doctors during COVID-19 pandemic
Authors: Huda Anwar Ul , Yasir Mohammad , Shamsuddin Abdul Sattar 
Published: June 2022

Vaccination against COVID-19 disease is making a significant difference in the outcome of the disease. This cross-sectional study was conducted at Security Forces Hospital, Riyadh, Saudi Arabia. Trainee doctors from different hospital departments, including surgery, medicine, emergency medicine, anesthesia and critical care units were included. The sample size was calculated to be 58. We used the Perceived Stress Scale (PSS-10) in our study. We distributed the questionnaire comprising PSS-10 questions to trainee doctors from different specialties. Each question in the scale was answered by the trainees on a 5-point scale ranging from never = 0, to very often = 4. The mean PSS-10 score was 18.93 ± 6.92. Ten (17.2 %) trainees had low stress, 43 (74.13 %) had moderate stress while 5 (8.6 %) trainees had high stress level.
Key words: Stress; Perceived Stress Scale; Vaccination; COVID-19
Citation: Huda AU, Yasir M, Shamsuddin AS. The impact of vaccination on stress level of trainee doctors during COVID-19 pandemic. Anaesth. pain intensive care 2022;26(3):423-424. DOI: 10.35975/apic.v26i3.1916
Received: October 08, 2021; Reviewed: October 21, 2021; Accepted: March 26, 2022