bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous renal replacement therapy combined with double filtration plasmapheresis in the treatment of severe lupus complicated by serious bacterial infections in children: A case report
Authors: Zhang Lei , Wei Feng , Su Guo-Yun , Lin Bo , Yang Wei-Guo 
Published: September 2022

Abstract
There are few reports available on the combination therapy of continuous renal replacement therapy (CRRT) and double filtration plasmapheresis (DFPP) in patients with systemic lupus erythematosus (SLE) complicated by severe bacterial infections, especially in children. A 14-year-old female child with recurrent SLE complicated by severe sepsis-induced multiple organ dysfunction syndrome was administered CRRT combined with DFPP for blood purification in addition to routine immunosuppressant therapy. The changes in autoantibodies, cytokines, and coagulation function indexes of the patient before and after treatment were compared to explore the effect of such therapy on progression and prognosis. After DFPP therapy, significant decreases in the levels of double-stranded DNA antibody, cytokines interleukin (IL)-6, IL-10, and procalcitonin (PCT) were observed. Fibrinogen (Fib) decreased and needed to be replenished following DFPP. After CRRT combined with DFPP, the patient began to urinate sparingly (urine volume was < 50 mL/day) at the seventh week, the urine volume was > 400 mL/day (up to 560 mL/day) at the ninth week (63 days), and the urine volume was >1,000 mL/day at the tenth week, at which time the renal function had fully recovered. DFPP may reduce the plasma Fib concentration, which needs to be replenished in a timely manner. CRRT combined with DFPP shows efficacy in patients with SLE, but the coagulation function requires close monitoring.
Determination of pediatric reference limits for 10 commonly measured autoantibodies
Authors: Sepiashvili Lusia , Bohn Mary Kathryn , Hall Alexandra , Henderson Tina , Chen Jack , Dunst Roseline , Adeli Khosrow 
Published: September 2022

Abstract

Objectives
The objective of this study was to establish pediatric reference limits for autoimmune disease markers in the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) cohort of healthy children and adolescents to support their interpretation and clinical decision making. The CALIPER is a national study of healthy children aiming to close gaps in pediatric laboratory medicine by establishing a robust database of pediatric reference intervals for pediatric disease biomarkers (caliperdatabase.org).

Methods
Healthy children and adolescents (n=123, aged 1–19) were recruited to CALIPER with informed consent. Serum autoantibody testing conducted on the BIO-FLASH analyzer (Werfen, Barcelona, Spain) included anti-dsDNA IgG, anti-Sm IgG, anti-RNP IgG, anti-SSB/La IgG, anti-Ro60 IgG, anti-Ro52 IgG, anti-cardiolipin IgG, anti-MPO IgG, anti-PR3 IgG, and anti-tTG IgA. Pediatric reference limits representing 95th, 97.5th, and 99th percentiles were calculated using the non-parametric rank method according to Clinical Laboratory Standards Institute C28-A3 guidelines.

Results
The proportion of samples with results above the lower limit of the analytical measuring range were: anti-cardiolipin IgG 90%, anti-dsDNA 22%, anti-Sm 13%, anti-RNP 0.8%, anti-SSB/La 0%, anti-Ro60 0%, anti-Ro52 0%, anti-MPO 25%, anti-PR3 9%, and anti-tTG IgA 28%. Pediatric reference limits and associated 90% confidence intervals were established for all 10 markers. All autoantibodies could be described by one age range except for anti-cardiolipin IgG and anti-MPO. A sex-specific difference was identified for anti-tTG IgA.

Conclusions
Robust pediatric reference limits for 10 commonly clinically utilized autoimmune markers established herein will allow for improved laboratory assessment and clinical decision making in pediatric patients using the BIO-FLASH assay platform worldwide.
Unfolding the mystery of premenstrual syndrome (PMS): an overview
Authors: Zehravi Mehrukh , Maqbool Mudasir , Ara Irfat 
Published: September 2022

Abstract
Physical, emotional, and psychological symptoms are common among women in their reproductive years, particularly during their menstrual cycle’s luteal phase and the week before their period. Approximately 5–8 percent of women suffer with premenstrual syndrome, with the majority of those suffering from premenstrual dysphoric disorder (PMDD). Because of the complexity and multifaceted nature of the aetiology, it is yet unknown. Premenstrual syndrome (PMS) is diagnosed entirely on the basis of signs and symptoms, with no particular diagnostic tests available to confirm the diagnosis. Only a small number of therapeutic modalities are backed by clinical data, yet there are many accessible. After providing a brief overview of the disease, the author goes on to discuss the various hypotheses as to why PMS occurs. With an emphasis on tailored treatment based on symptom profile, it examines the wide range of non-pharmacological and pharmaceutical methods that are accessible today.
The Social Supportive Role of Food and Meals Following Hurricane Florence
Authors: Clay Lauren , Greer Alex , Slotter Rachel , King Danielle 
Published: September 2022

Abstract
This study uses the Theory of Social Support to examine the impact of Hurricane Florence on the local food system during the immediate response to the disaster focusing on the social supportive nature of food and meals. Using a quick response disaster research methodology, field observations and qualitative interviews were conducted in Eastern North Carolina, in the days following Hurricane Florence in September 2018. Individuals affected by Hurricane Florence were recruited from emergency food and meal distribution sites. A codebook consisting of 66 parent and child codes based on the Theory of Social Support was applied to analyze 23 individual interviews. Sharing food with neighbors and/or relatives and utilizing post-disaster community feeding services improved the coping capacity of survivors. Results from this study contribute to the understanding of the post-disaster food environment and may help to improve food related response and recovery to meet the needs of those affected.
Covid and pregnancy in the United States – an update as of August 2022
Authors: Grünebaum Amos , Dudenhausen Joachim , Chervenak Frank A. 
Published: September 2022

Abstract
COVID-19 is caused by the 2019 novel coronavirus (2019-nCoV). The first cases of COVID-19 were identified in December 2019, and the first United States (US) case was identified on January 20th, 2020. Since then, COVID-19 has spread throughout the world and was declared a pandemic by the WHO on March 11, 2020. As of July 2022, about 90 million persons have been infected with COVID-19 in the US, and there have been over 1 million deaths There have been 224,587 pregnant patients infected with COVID-19, and 34,527 were hospitalized. Pregnancy increases the risk of severe disease associated with COVID-19 and vaccinated patients are significantly less likely to develop severe disease. Adverse pregnancy and neonatal outcomes are more common among women infected with SARS-CoV-2 during pregnancy, especially among those with severe disease, and vaccination also protects the newborn infant. The intrauterine transmission of SARS-CoV-2 appears to be rare. COVID-19 vaccinations and booster shots in pregnancy are safe. In addition, the available data suggest that vaccination during pregnancy is associated with the transmission of SARS-CoV-2 antibodies to the fetus. The vaccination of lactating women is associated with high levels of SARS-CoV-2 antibodies in the breast milk. It is important that with future pandemics the concept of vaccine recommendations in pregnancy should be made early on to prevent maternal, fetal, and neonatal morbidity and mortality. Physicians and other healthcare professionals should strongly recommend COVID-19 vaccination to patients who are pregnant, planning to become pregnant, and to those who are breastfeeding.
Two-dimensional nanostructures based ‘-onics’ and ‘-omics’ in personalized medicine
Authors: Francis Bibi Mary , Sundaram Aravindkumar , Manavalan Rajesh Kumar , Peng Weng Kung , Zhang Han , Ponraj Joice Sophia , Chander Dhanabalan Sathish 
Published: September 2022

Abstract
With the maturing techniques for advanced synthesis and engineering of two-dimensional (2D) materials, its nanocomposites, hybrid nanostructures, alloys, and heterostructures, researchers have been able to create materials with improved as well as novel functionalities. One of the major applications that have been taking advantage of these materials with unique properties is biomedical devices, which currently prefer to be decentralized and highly personalized with good precision. The unique properties of these materials, such as high surface to volume ratio, a large number of active sites, tunable bandgap, nonlinear optical properties, and high carrier mobility is a boon to ‘onics’ (photonics/electronics) and ‘omics’ (genomics/exposomics) technologies for developing personalized, low-cost, feasible, decentralized, and highly accurate medical devices. This review aims to unfold the developments in point-of-care technology, the application of ‘onics’ and ‘omics’ in point-of-care medicine, and the part of two-dimensional materials. We have discussed the prospects of photonic devices based on 2D materials in personalized medicine and briefly discussed electronic devices for the same.
The Fall of Jerusalem: Cultural Trauma as a Process
Authors: Ammann Sonja 
Published: September 2022

AbstractCultural trauma theory provides a framework for studying the socio-cultural process which takes place between an event and its (socially accepted) representation. This article will apply the process-oriented approach of cultural trauma theory to studying biblical narratives of the Babylonian conquest of Jerusalem, focusing in particular on the destruction and pillage of the temple. The comparison of the various accounts of the Babylonian conquest of Jerusalem, and of their different versions transmitted in Hebrew and in Greek, reveals that the memory of this event was by no means unified and developed over a longer period of time. Discussing passages from 2 Kgs 24–25 and their parallels in the book of Jeremiah, this article will argue that the devastation of the temple of Jerusalem, which is often regarded as a major traumatizing event in the history of ancient Judah, became remembered as such only as the result of a longer process.
Rapid microwave synthesis of magnetic nanoparticles in physiological serum
Authors: Girardet Thomas , Che Dji Lyns Verel , Bouguet-Bonnet Sabine , Cleymand Franck , Fleutot Solenne 
Published: September 2022

Abstract
Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are more and more used in biomedical applications such as therapy (treatment for certain cancers, hyperthermia), diagnostic (contrast agent for Magnetic Resonance Imaging) or both. For these applications, SPIONs must be stable in an aqueous solution, monodisperse, with a narrow size distribution and without aggregation. To obtain these nanoparticles, a microwave process is carried out in this study as an easy, fast and reproducible synthesis method. Currently, in the literature, most synthesis of SPIONs are in ultra-pure water or another solvent. To consider the use of SPIONs in biomedical applications, it is essential to ensure the preservation of the physico-chemical parameters of the nanoparticles in the physiological medium to validate a synthesis process. With this objective, this study reports a comparison between the SPIONs synthesis in ultra-pure water and the SPIONs direct synthesis in a physiological serum (containing NaCl). To complete this comparison, the dispersion of SPIONs in physiological serum after an elaboration in ultra-pure water is reported. Characterizations of these different SPIONs samples are carried out to determine the physico-chemical parameters and magnetic properties. SPIONs are characterized by Transmission Electronic Microscopy, Dynamic Light Scattering, X-Ray Diffraction, Raman spectroscopy and magnetic measurements. Finally, to check if SPIONs can be used as contrast agent for MRI, a relaxometry measurement is performed.
New and refined bond valence parameters for Te4+–F−, Te4+–S2− and Te4+–Se2− ion pairs
Authors: Hamani David , Torzuoli Lyna , Bouzid Assil , Thomas Philippe , Masson Olivier 
Published: September 2022

Abstract
New and refined bond valence parameters related to ion pairs constituted of the tellurium Te4+ cation and non-oxide X
n− anions (X = F, S or Se) are proposed. After a selection of specific crystalline structures, the optimization of the bond valence parameters R and b with a cutoff distance is carried out by minimizing the root mean square deviation of the Te4+ cation valence. The results are R = 1.728 Å and b = 0.622 Å with cutoff = 5.3 Å for the Te4+–F− pair and R = 2.444 Å and b = 0.387 Å with cutoff = 4.5 Å for the Te4+–S2− pair. These parameters lead to a lower dispersion of the calculated valences around the formal valence compared to that obtained with the parameters available in the literature. As for the new set related to the Te4+–Se2− pair, we find R = 2.578 Å and b = 0.296 Å with cutoff = 3.7 Å.
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling
Authors: Sun Dawei , Llora Batlle Oriol , van den Ameele Jelle , Thomas John C , He Peng , Lim Kyungtae , Tang Walfred , Xu Chufan , Meyer Kerstin B , Teichmann Sarah A , Marioni John C , Jackson Stephen P , Brand Andrea H , Rawlins Emma L 
Published: September 2022

AbstractThe balance between self‐renewal and differentiation in human foetal lung epithelial progenitors controls the size and function of the adult organ. Moreover, progenitor cell gene regulation networks are employed by both regenerating and malignant lung cells, where modulators of their effects could potentially be of therapeutic value. Details of the molecular networks controlling human lung progenitor self‐renewal remain unknown. We performed the first CRISPRi screen in primary human lung organoids to identify transcription factors controlling progenitor self‐renewal. We show that SOX9 promotes proliferation of lung progenitors and inhibits precocious airway differentiation. Moreover, by identifying direct transcriptional targets using Targeted DamID, we place SOX9 at the centre of a transcriptional network, which amplifies WNT and RTK signalling to stabilise the progenitor cell state. In addition, the proof‐of‐principle CRISPRi screen and Targeted DamID tools establish a new workflow for using primary human organoids to elucidate detailed functional mechanisms underlying normal development and disease.
Chinese Community under the Soekarno Era in Indonesia
Authors: Permana Septian Aji , Purwantiningsih Ary 
Published: September 2022

Abstract: This study aims to analyze the life of Chinese people in Indonesia during the Soekarno government and analyze the governmentâ€™s treatment of Chinese people in the Soekarno era. This study used a historical method approach with a limited history across the 1930s period, from 1941 to 1958, from 1959 to 1966. The method used is as follows: data collection in the form of literature studies relevant to the subject matter discussed, source criticism to find out the relevant elements through the incorporation of information obtained through the source, and compilation i.e., writing historical facts. Political and economic perceptions influenced Chinese ethnic communities in Indonesia during colonial, the old order, and the new times. Chinese society received many sanctions from the Soekarno government because of communist ideology, which was a threat to the government. The existence of ethnocentric during the old order so that Chinese people cannot be received well.Â Abstrak: Penelitian ini bertujuan untuk menganalisis kehidupan masyarakat Tionghoa di Indonesia pada masa pemerintahan Soekarno dan menganalisis perlakuan pemerintah terhadap orang Tionghoa pada masa pemerintahan Soekarno. Penelitian ini menggunakan pendekatan metode sejarah dengan sejarah terbatas pada periode tahun 1930-an, dari tahun 1941 hingga 1958, dari tahun 1959 hingga tahun 1966. Metode yang digunakan adalah sebagai berikut: pengumpulan data berupa studi pustaka yang relevan dengan materi pelajaran yang dibahas, kritik sumber untuk mengetahui unsur-unsur yang relevan melalui penggabungan informasi yang diperoleh melalui sumber, dan kompilasi yaitu, menulis fakta sejarah. Persepsi politik dan ekonomi mempengaruhi komunitas etnis Tionghoa di Indonesia pada masa penjajahan, Soekarno, dan Orde Baru. Masyarakat Tionghoa banyak mendapat sanksi dari pemerintah Soekarno karena ideologi komunis yang menjadi ancaman bagi pemerintah. Adanya etnosentris pada masa Soekarno sehingga masyarakat Tionghoa tidak bisa diterima dengan baik.Â
Deli Maatschappij's Contribution to the Transformation of East Sumatera, 1869-1940s
Authors: Darini Ririn 
Published: September 2022

Abstract: Indonesian historiography notes that East Sumatra is known for its poor treatment of plantation companies towards their workers. Nevertheless, the presence of plantation companies also causes East Sumatra to grow rapidly.Â This study aims to uncover the contributions provided by Deli Maatschappij in transforming East Sumatra into a more modern one and its impacts on plantation communities and local communities. The study uses critical historical methods that include heuristic activities, source criticism, interpretation, and historiography. The approach of social science is used as an analytical tool. The sources used in this study include the Deli Maatschappij memorial books, magazines, and other sources from the period. The results showed that Deli Maatschappij had a significant contribution to East Sumatra's transformation process, primarily related to its role in changes in transportation systems, health services, water supply, and education. It can be concluded that the community also had a positive impact from these changes.Â Abstrak: Historiografi Indonesia mencatat bahwa Sumatera Timur dikenal dengan perlakuan buruk perusahaan perkebunan terhadap pekerjanya. Kendati demikian, kehadiran perusahaan perkebunan juga menyebabkan Sumatera Timur berkembang pesat. Studi ini bertujuan untuk mengungkap kontribusi yang diberikan oleh Deli Maatschappij dalam mengubah Sumatera Timur menjadi lebih modern dan dampaknya terhadap masyarakat perkebunan dan masyarakat lokal. Penelitian ini menggunakan metode sejarah kritis yang meliputi kegiatan heuristik, kritik sumber, interpretasi, dan historiografi. Pendekatan ilmu sosial digunakan sebagai alat analisis. Sumber yang digunakan dalam penelitian ini antara lain buku peringatan Deli Maatschappij, majalah, dan sumber lain dari periode tersebut. Hasil penelitian menunjukkan bahwa Deli Maatschappij memiliki kontribusi yang sangat signifikan terhadap proses transformasi di Sumatera Timur terutama terkait perannya dalam perubahan sistem transportasi, pelayanan kesehatan, penyediaan air bersih, dan pendidikan. Dapat disimpulkan bahwa masyarakat juga merasakan dampak positif dari perubahan tersebut.Â Â
Etyka seksualna, małżeństwo i rodzina jako zniewolenie czy ostoja prawdziwej wolności? Analiza obrony małżeństwa i rodziny w pismach Gilberta Keitha Chestertona
Authors: Laskowska Ewa 
Published: September 2022

The cultural revolution proceeds through history bringing liberation to the oppressed man. After liberating him from the oppression of the social class, it proclaims liberation from cultural norms, sexual ethics, unbreakable marriage, the difficulties caused by having a family, and even the liberation of a person from his or her own specific gender. But is it really a liberation? According to Gilbert Keith Chesterton, who witnessed the beginnings of social changes that took place at the turn of the 19th and 20th centuries, the revolution in manners may lead to a more sophisticated form of bondage – the bondage of the mind.The article examines the defense of sexual ethics, marriage and family as presented by Chesterton in his writings, trying to answer the questions: can Chesterton’s voice be relevant and intriguing today; can it complement the present discussion with a new point of view.The article indicates that the writer changes the perspective. He points that it is not Catholic sexual ethics, the indissolubility of marriage and the family that enslave man. But the constant changes, sexual freedom and divorce lead to the weakening of human will and intellectual enslavement. Because true freedom is hidden in a non-obvious and paradoxical way precisely in adherence to sexual ethics, a stable marriage and family, which are not only Christian but also extremely rational ideals.
Filozoficzna droga kard. Mariana Jaworskiego: od metafizyki ogólnej do szczegółowej i stosowanej
Authors: Mikucki Kazimierz 
Published: September 2022

The article is an attempt to present the philosophical achievements of Marian Jaworski in terms of the basic method and direction of his thoughts as well as the most important ideas. These ideas are particularly present in his last book, which constitutes the third volume of his work, in which the vast majority of his most recent articles are included. They are a testimony to the way he understood philosophy and the problems it raises. They are also the most persuading sign of the process of evolution that took place in his scientific life. It is evidenced by the existence of three, quite clearly outlined, phases in his philosophical research. Each one is distinct from another in terms of prevailing methodology used, and the philosophical questions which had been raised. The first phase of his philosophical investigations was connected with general metaphysics. The second one was related to the application of the ideas of special and applied metaphysics on the basis of the cognitive tools of general metaphysics in the main philosophical disciplines (philosophy of religion, philosophical anthropology and philosophy of God). The third one, however, was expressed in the application of the above mentioned met- aphysical ideas in more specialized philosophical disciplines, such as Christian philosophy (e.g. philosophy of prayer, philosophy of consecrated life), and in the philosophy of specifically human phenomena (philosophy of suffering, of humanism and of dialogue).
Effectiveness of mammography screening for women aged 40–49
Authors: Belaya Yu. A. 
Published: September 2022

The aim of the work was to review randomized controlled trials regarding the efficacy of screening mammography in women aged 40–49 years.Google Scholar and PubMed databases were searched for English-language publications for randomized controlled trials. Inclusion criteria were studies evaluating the possible benefit/harm of mammographic screening in women 40–49 years old, a follow-up period of at least 10 years, primary breast cancer, regarding as primary outcomes reduction of breast cancer mortality, and side effects screening mammography.A search for the specified keywords found 2453 sources in electronic databases, of which only 83 studies were published as articles. After analyzing these studies, only 5 studies met the inclusion criteria. An analysis of these studies according to the inclusion criteria is subsequently presented in the article.Based on the available data from randomized trials, no definitive conclusion about the effectiveness of mammographic screening in women 40–49 years of age can yet be drawn. Therefore, it is too early to draw a line in the debate about the appropriateness of mammography in the 40–49 age group.