bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability of clockwise rotation of the maxillary occlusal plane in skeletal Class III patients treated with two‐jaw surgery
Authors: Kang Soon‐Young , Kim Young Ho , Baek Seung‐Hak , Kim Dong Woo , Shin Jeong Won , Chae Hwa Sung 
Published: August 2022

AbstractObjectiveThe objective of the study was to investigate the post‐surgical stability of clockwise rotation of the maxillary occlusal plane (MXOP) after Le Fort I osteotomy for posterior impaction and advancement, in skeletal Class III patients who had undergone two‐jaw orthognathic surgery (2J‐OGS).Materials and MethodsThe sample set consisted of 46 patients (18 males and 28 females). Using lateral cephalograms taken at the initial evaluation (T0), before 2J‐OGS (T1), after 2J‐OGS (T2) and at debonding (T3), the amount of MXOP change (criterion: 2° in ΔMXOP [between T2 and T3]) was used to assign patients to Group 1 (G1, high relapse, −3.09°) or Group 2 (G2, low relapse, −0.99°). Findings were statistically compared between the groups.ResultsCompared with G2, G1 exhibited more severe skeletal Class III relationships and a flatter MXOP at T0, a greater increase in ΔANB, and more clockwise rotation of ΔMXOP and ΔFMA between T1 and T2. G1 also showed a greater decrease in ΔANB, higher counterclockwise rotation of ΔMXOP and upward movement of U1 between T2 and T3. Regression analysis yielded the following equation: MXOP (ΔT2‐T3) = −0.37 X MXOP (ΔT1‐T2) −0.43.ConclusionsThe higher the clockwise rotation of the MXOP during 2J‐OGS in skeletal Class III patients, the greater the subsequent relapse (counterclockwise rotation) of the MXOP.
Impact of very early recurrence of atrial fibrillation after cryoballoon ablation
Authors: Ukita Kohei , Egami Yasuyuki , Kawanami Shodai , Sugae Hiroki , Kawamura Akito , Nakamura Hitoshi , Yasumoto Koji , Tsuda Masaki , Okamoto Naotaka , Matsunaga‐Lee Yasuharu , Yano Masamichi , Nishino Masami , Tanouchi Jun 
Published: August 2022

AbstractBackgroundAlthough much has been discussed about the early recurrence of atrial fibrillation (ERAF) after cryoballoon ablation (CBA), the clinical impact of very early recurrence of atrial fibrillation (VERAF) after CBA remains unclear. This study aimed to investigate the impact of VERAF after CBA.MethodsWe enrolled 236 consecutive patients who underwent an initial CBA for paroxysmal atrial fibrillation between February 2017 and December 2020 in our hospital. These patients were categorized into three groups: VERAF group who experienced an initial recurrence of atrial tachyarrhythmia within 48 h after CBA, late‐ERAF (LERAF) group who experienced an initial recurrence of atrial tachyarrhythmia between 48 h and 3 months after CBA, and non‐ERAF (NERAF) group who did not experience a recurrence of atrial tachyarrhythmia within 3 months after CBA. We investigated the late recurrence of AF (LRAF, defined as recurrence of atrial tachyarrhythmia more than 3 months after CBA), and the incidence of non‐pulmonary vein (PV) triggers in the patients who experienced a repeat ablation procedure due to LRAF.ResultsVERAF group had a higher incidence of freedom from LRAF than LERAF group (p = 0.032) and a lower incidence of freedom from LRAF than NERAF group (p = 0.002). Moreover, VERAF group had the highest incidence of non‐PV triggers at repeat ablation procedure among the three groups (p = 0.003).ConclusionsWhile ERAF was a predictor of LRAF, VERAF was less related to LRAF among the patients with ERAF after CBA. Furthermore, VERAF might be associated with non‐PV triggers.
The preventive effect of internet‐based cognitive behavioral therapy for prevention of depression during pregnancy and in the postpartum period (iPDP): a large scale randomized controlled trial
Authors: Nishi Daisuke , Imamura Kotaro , Watanabe Kazuhiro , Obikane Erika , Sasaki Natsu , Yasuma Naonori , Sekiya Yuki , Matsuyama Yutaka , Kawakami Norito 
Published: August 2022

BackgroundPrevention of perinatal depression beginning from the antenatal period is essential. Therefore, this study aimed to investigate the effectiveness of recently developed internet‐delivered cognitive behavioral therapy (iCBT) for preventing the onset of a major depressive episode (MDE) in the third trimester and at 3 months postpartum.MethodsThis is a two‐arm, parallel‐group, general‐information controlled, randomized controlled trial. Participants were 5017 pregnant women at 16–20 weeks' gestation without MDE at baseline. They were randomly assigned to an iCBT (intervention; n = 2509) or general‐information (control; n = 2508) group, stratified by psychological distress at baseline. The primary outcomes were the numbers of new MDE onsets, measured using the World Health Organization Composite International Diagnostic Interview 3.0, at 32 weeks' gestation and at 3 months postpartum.ResultsNew MDE onset was reported by 59 participants (2.35%) in the intervention group and 73 (2.91%) in the control group during follow‐up. Compared with the control group, the hazard ratio (HR) of MDE in the intervention group was 0.85 (95% CI 0.61–1.20), which was not significantly different. Among participants who scored between 5 and 8 on K6 at baseline, 10 (1.37%) in the intervention group reported new onset of MDE, compared with 28 (3.81%) in the control group, and the HR of MDE was 0.38 (95%CI 0.19–0.79).ConclusionsNo intervention effect was found for iCBT in preventing new onset of perinatal MDE. iCBT might prevent perinatal depression only among pregnant women with subthreshold depressive symptoms. Trial registration: UMIN000038190.
Cognitive assessment in the time of pandemics: mandatory surgical face mask usage affects cognitive test performance of older adults
Authors: Okyar Baş Arzu , Güner Oytun Merve , Ceylan Serdar , Öztürk Yelda , Kahyaoğlu Zeynep , Çavuşoğlu Çağatay , Balcı Cafer , Halil Meltem Gülhan , Cankurtaran Mustafa , Doğu Burcu Balam 
Published: August 2022

BackgroundThe most important disadvantage of surgical mask usage is that it can aversely affect communication. This study aimed to evaluate the possible effects of face masks on the cognitive test performance of older adults.MethodsA total of 198 geriatric patients were enrolled after applying the exclusion criteria. Within the comprehensive geriatric assessment (CGA), cognitive status assessment was performed with the Mini‐Mental State Examination test (MMSE) and Quick Mild Cognitive Impairment Screening test (Q‐MCI) tests.ResultsThe median age was 70 (66–77) years, and there were 119 female (60.7%) patients. Patients were divided into normal cognitive status (NC), mild cognitive impairment (MCI), and probable Alzheimer's disease (AD) groups. There were 129 (65.2%), 30 (15.2%), and 37 (18.7%) patients in each group, respectively. For differentiating MCI from NC, calculated optimal cut‐offs for the Q‐MCI and MMSE total scores were ≤50 (sensitivity 83.3%, specificity 90.7%) and ≤26 (sensitivity 63.3%, specificity 87.5%), respectively. For differentiating AD from MCI, calculated optimal cut‐offs for the Q‐MCI and MMSE total scores were ≤28 (sensitivity 76.8%, specificity 86.7%), and ≤24 (sensitivity 94.4%, specificity 64.5%), respectively.ConclusionOur results revealed that screening tests are still sensitive in discriminating cognitive disorders although cut‐offs are lower with mask usage than for previously validated cut‐offs. This is the first study revealing the impact of surgical mask usage on cognitive test performance, indicating that cut‐offs validated before the pandemic may cause overdiagnosing of cognitive disorders since the previous cut‐offs are not validated for mask usage. Large sample studies are needed to determine new cut‐offs validated with mask usage.
Wage bargaining and employment revisited: separability and efficiency in collective bargaining*
Authors: Haake Claus‐Jochen , Upmann Thorsten , Duman Papatya 
Published: August 2022

AbstractWe analyse the two‐dimensional Nash bargaining solution (NBS) by deploying the standard labour market negotiations model of McDonald and Solow. We show that the two‐dimensional bargaining problem can be decomposed into two one‐dimensional problems, such that the two solutions together replicate the solution of the two‐dimensional problem if the NBS is applied. The axiom of “independence of irrelevant alternatives” is shown to be crucial for this type of decomposability. This result has significant implications for actual negotiations because it allows for the decomposition of a multi‐dimensional bargaining problem into one‐dimensional problems – and thus helps to facilitate real‐world negotiations.
Integrative taxonomy documents two additional crypticErithacusspecies on the Canary Islands (Aves)
Authors: Sangster George , Luksenburg Jolanda A. , Päckert Martin , Roselaar Cees S. , Irestedt Martin , Ericson Per G. P. 
Published: August 2022

AbstractThe European RobinErithacus rubeculais currently treated as a single species with eight subspecies. A previous molecular study and new molecular, morphometric and bioacoustic data reported here strongly support the recognition of three species in this complex:E. rubecula(Europe, North Africa and Macaronesia except the central Canary Islands),E. superbus(Tenerife) and a recently described subspecies on Gran Canaria which we raise to species rank asE. marionae. The taxa on Tenerife and Gran Canaria have previously been lumped as a single taxon but differ from each other and fromE. rubeculain territorial songs,ticcalls,seepcalls and wing length. All three species are characterised by moderate to high levels of interspecific mitochondrial DNA sequence divergence (mean 4.2–4.8%). Phylogenetic analysis indicates thatE. marionaeis sister toE. superbus + E. rubecula. Recognition of Gran Canaria and Tenerife Robins as separate species adds two single‐island endemics to the Canary Islands avifauna.
Stories From Mother Runners: A Case Study and Narrative Analysis of Facilitators for Competitive Running
Authors: McGannon Kerry R. , McMahon Jenny 
Published: August 2022

Despite the focus on motherhood and sport participation in recent years, the motherhood and recreational sport participation nexus is not well understood. Using an instrumental case study, we explored running facilitators for competitive recreational mother runners to advance research using a novel theory (i.e., narrative inquiry). We used a dialogical narrative analysis to identify a key theme of “good mother runners: negotiating freedom and constraint.” Findings are presented using a storyteller approach in the form of three portrait characters who each tell a story of facilitators grounded in a “relational narrative” that provided freedom to run in the context of good motherhood. The features of the relational narrative are shown in three nonfiction vignettes: Susan’s story, “Running is what we do”; Tracy’s story, “Running isn’t just for me, it’s for them”; and Kay’s story, “Just go with it.” Interpretive reflections of the stories using narrative theory are offered. We conclude with practical recommendations and future research directions for mothers’ competitive running participation.
Prevalence of and factors associated with osteoarthritis and pain in retired Olympians compared with the general population: part 2 – the spine and upper limb
Authors: Palmer Debbie , Cooper Dale , Whittaker Jackie L , Emery Carolyn , Batt Mark E , Engebretsen Lars , Schamasch Patrick , Shroff Malav , Soligard Torbjørn , Steffen Kathrin , Budgett Richard 
Published: August 2022

Objectives(1) To determine the prevalence of spine and upper limb osteoarthritis (OA) and pain in retired Olympians; (2) identify risk factors associated with their occurrence and (3) compare with a sample of the general population.Methods3357 retired Olympians (44.7 years) and 1735 general population controls (40.5 years) completed a cross-sectional survey. The survey captured demographics, general health, self-reported physician-diagnosed OA, current joint/region pain and significant injury (lasting ≥1 month). Adjusted ORs (aORs) compared retired Olympians and the general population.ResultsOverall, 40% of retired Olympians reported experiencing current joint pain. The prevalence of lumbar spine pain was 19.3% and shoulder pain 7.4%, with lumbar spine and shoulder OA 5.7% and 2.4%, respectively. Injury was associated with increased odds (aOR, 95% CI) of OA and pain at the lumbar spine (OA=5.59, 4.01 to 7.78; pain=4.90, 3.97 to 6.05), cervical spine (OA=17.83, 1.02 to 31.14; pain=9.41, 6.32 to 14.01) and shoulder (OA=4.91, 3.03 to 7.96; pain=6.04, 4.55 to 8.03) in retired Olympians. While the odds of OA did not differ between Olympians and the general population, the odds of lumbar spine pain (1.44, 1.20 to 1.73), the odds of shoulder OA after prior shoulder injury (2.64, 1.01 to 6.90) and the odds of cervical spine OA in female Olympians (2.02, 1.06 to 3.87) were all higher for Olympians compared with controls.ConclusionsOne in five retired Olympians reported experiencing current lumbar spine pain. Injury was associated with lumbar spine, cervical spine and shoulder OA and pain for Olympians. Although overall OA odds did not differ, after adjustment for recognised risk factors, Olympians were more likely to have lumbar spine pain and shoulder OA after shoulder injury, than the general population.
Genetics of validated Parkinson’s disease subtypes in the Oxford Discovery and Tracking Parkinson’s cohorts
Authors: Lawton Michael , Tan Manuela MX , Ben-Shlomo Yoav , Baig Fahd , Barber Thomas , Klein Johannes C , Evetts Samuel G , Millin Stephanie , Malek Naveed , Grosset Katherine , Barker Roger A , Williams Nigel , Burn David J , Foltynie Thomas , Morris Huw R , Wood Nicholas , Grosset Donald G , Hu Michele Tao-Ming 
Published: August 2022

ObjectivesTo explore the genetics of four Parkinson’s disease (PD) subtypes that have been previously described in two large cohorts of patients with recently diagnosed PD. These subtypes came from a data-driven cluster analysis of phenotypic variables.MethodsWe looked at the frequency of genetic mutations in glucocerebrosidase (GBA) and leucine-rich repeat kinase 2 against our subtypes. Then we calculated Genetic Risk Scores (GRS) for PD, multiple system atrophy, progressive supranuclear palsy, Lewy body dementia, and Alzheimer’s disease. These GRSs were regressed against the probability of belonging to a subtype in the two independent cohorts and we calculated q-values as an adjustment for multiple testing across four subtypes. We also carried out a Genome-Wide Association Study (GWAS) of belonging to a subtype.ResultsA severe disease subtype had the highest rates of patients carrying GBA mutations while the mild disease subtype had the lowest rates (p=0.009). Using the GRS, we found a severe disease subtype had a reduced genetic risk of PD (p=0.004 and q=0.015). In our GWAS no individual variants met genome wide significance (<5×10e-8) although four variants require further follow-up, meeting a threshold of <1×10e-6.ConclusionsWe have found that four previously defined PD subtypes have different genetic determinants which will help to inform future studies looking at underlying disease mechanisms and pathogenesis in these different subtypes of disease.
059 Cannabidiol in refractory adult epilepsies: broadening the Lennox-Gastaut phenotype?
Authors: Bose Smriti , Wysota Barbara , Samarasekera Shanika 
Published: August 2022

PurposeCannabidiol has been licensed in the UK for those with refractory seizures associated with Lennox Gastaut Syndrome (LGS). However, characterizing LGS in adults can be challenging. Patients are frequently too agitated to tolerate EEG monitoring. Many patients are monitored by carers whose expertise may be variable; identifying seizures, particularly non convulsive manifestations such as atonic head drops or sleep-related tonic seizures, is therefore unreliable. We sought to ascertain whether those with an LGS-type syndrome – refractory multifocal epilepsy with cognitive impairment and multiple seizure types arising in childhood, would benefit from Cannabidiol. These patients did not have the typical elec- troclinical phenotype for LGS.MethodIndividual Funding Requests were made for five patients. Four had genetically defined syndromes- Alternating Hemiplegia of Childhood, Batten’s disease (CLN5), CHD2 related epileptic encephalopathy and Tuberous Sclerosis. One had Febrile Related Epilepsy Syndrome (FIRES) of unknown aetiology. Patients were commenced on adjunctive Cannabidiol between March and December 2021. All patients were prescribed Clobazam.ResultsCannabidiol at a maximum dose of 5mg/kg lead to significant seizure reduction (>50%) in 3 patients. Our patient with Tuberous Sclerosis was the only one who did not experience a reduction in seizure intensity.ConclusionCannabidiol is potentially efficacious in adult patients with severe refractory epilepsy ‘outside’ the typical LGS phenotype.
061 The long-term effects of anterior temporal lobe resection on memory encoding: A longitudinal fMRI study
Authors: Fleury Marine , Buck Sarah , Thompson Pamela , Duncan John , Sidhu Meneka 
Published: August 2022

Episodic memory functions are impaired in up to 40% of patients with temporal lobe epilepsy (TLE) following anterior temporal lobe resection (ATLR). Little is known of plasticity effects beyond one year postoperatively. We describe the dynamic plasticity of memory encoding networks long-term after ATLR.Sixteen patients with TLE (8 left-sided) and six controls performed a memory-encoding fMRI paradigm of faces and words across equivalent time-points (pre-surgery, 4, 12 months, and 7–10 years post-surgery). Flexible factorial designs probed the changes in fMRI activations in patients between 12 months and long-term postoperatively, relative to longitudinal changes in controls. Clinical memory scores (list- and design-learning) were correlated with changes in activations.From 1 to 10 years postoperatively, prefrontal cortex (PFC) activations were increased ipsilaterally for word encoding after left ATLR and bilaterally for face encoding after left and right ATLR. After left ATLR, improvement in visual memory correlated with increased contralateral amygdala, insula, and PFC acti- vations. After right ATLR, right fusiform gyrus and temporo-parietal activations positively correlated with visual memory. Better verbal memory correlated with increased right fusiform gyrus and PFC activations.Years after left and right ATLR, there is continued contralateral and ipsilateral plasticity which is supportive of memory functions.
066 The Utility of 18-FDG PET imaging in the preoperative workup for epilepsy surgery
Authors: Wrigley Sarah , Reynolds Audrey , O’Regan Kevin , Costello Daniel 
Published: August 2022

For patients with refractory focal epilepsy, surgical resection of the epileptogenic zone can lead to a drastic reduction in seizure frequency. Careful localisation of the epileptogenic zone is imperative in the presurgical workup. Up to 20% patients with refractory focal epilepsy have a normal MRI and are less likely to be referred for epilepsy surgery. As a result, 18-FDG-PET has been employed to localise the epileptogenic focus, which appears as a region of hypometabolism. This study examines the real-world utility of 18-FDG-PET imaging among patients undergoing for presurgical assessments over a 5-year period.Between January 2015 and March 2020, 65/90 patients referred for presurgical assessment underwent 18-FDG PET. In total, 26/65 (40%) patients had corresponding focal abnormalities on 18-FDG PET and MRI studies, of whom 22 had focal epileptiform activity on video-EEG (80.1%). Therefore, where 18-FDG PET and MRI agree, there is a high predictive value for successful seizure localisation with video-EEG moni- toring. Furthermore, 33/65 (40.7%) patients had MRI-negative epilepsy, of whom 17/33 (51.1%) had focal hypometabolism on 18-FDG PET. Thus, over half of our patient cohort with “non-lesional” or MRI-negative epilepsy were able to proceed to intracranial video-EEG monitoring or resective surgery with the help of supportive data from 18-FDG PET imaging.
072 Fenfluramine directly inhibits cortical spreading depolarisation: a patho physiologic process linked to SUDEP
Authors: Ning Yao , Noebels Jeffrey , Aiba Isamu , Reeder Thaad 
Published: August 2022

RationaleFenfluramine substantially reduces rates of sudden unexplained death in epilepsy (SUDEP) in Dravet syndrome (Cross JH et al, AES 2020). Fenfluramine reduces respiratory arrest in the DBA/1 SUDEP mouse model (Tupal and Faingold,Epilepsia. 2019). Spreading depolarisation (SD) is a pathophysiologic event linked to cardiorespiratory collapse in SUDEP models. We report that fenfluramine inhibits SD, and explore its potential inhibitory mechanisms.MethodsWe examined the effects of fenfluramine on SD evoked by KCl or oxygen glucose deprivation (OGD) in cortical brain slices of adult C57Bl/6 mice. We also measured the effect on GABAAR-mediated inhibitory postsynaptic currents (sIPSC) in vitro.ResultsFenfluramine increased the threshold for SD events at clinically relevant concentration ranges (~10 µM). Blocking GABAARs with gabazine did not fully occlude SD inhibition by fenfluramine, suggesting that GABAAR potentiation is not involved in the inhibitory SD mechanism of fenfluramine.ConclusionOur results demonstrate that fenfluramine directly inhibits SD generation without acting via a neurovascular mechanism suggesting that SD inhibition could account for the decrease in expected rates of SUDEP in patients treated with fenfluramine.
074 No valvular heart disease or pulmonary artery hypertension with fenfluramine for up to 3 years
Authors: Agarwal Anupam , Galer Bradley , Gammaitoni Arnold , Wong Pierre , Pinto Fausto 
Published: August 2022

RationaleFenfluramine (FFA) has been shown in 2 randomised, placebo-controlled clinical trials to reduce convulsive seizures in children with Dravet Syndrome (DS). We report an update on the cardiovascular safety of DS patients treated with FFA for up to 3 years.Methods327 patients who completed one of the three phase 3 trials enrolled in this open-label extension (OLE) study (NCT02823145). All were assessed with transthoracic echocardiography (TTE). They were assessed for Valvular Heart Disease (VHD) and Systolic pulmonary artery pressure.ResultsOne patient had a finding of mild MR (considered physiologic) during the study. One patient demonstrated mild (considered pathologic) AR at Month 15. A transoesophageal echocardiogram (TOE) performed at 6 weeks found absent AR with trace MR. No abnormalities of valve morphology were found on TOE or on TTE. No VHD or PAH was observed in any patient during the OLE.ConclusionsThis study demonstrates the absence of clinically significant VHD or PAH supporting a positive benefit-risk profile for FFA in the treatment of patients with DS.