bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of the performance outcome scoring template (POS-T) with example application on CO2 emissions reduction amongst 36 OECD member countries
Authors: Raysmith Benjamin P. , Timpka Toomas , Jacobsson Jenny , Drew Michael K. , Dahlström Örjan 
Published: March 2022

AbstractIn applied program settings, such as in natural environment control and education, performance evaluation is usually conducted by evaluators considering both self-comparison and comparison with peers. We have developed the performance outcome scoring template (POS-T) for assessments with high face-validity in these settings. POS-T puts achievements of individuals or groups in context, i.e. the resulting performance outcome score (POS) reflects a meaningful measure of performance magnitude with regards to internal and external comparisons. Development of a POS is performed in four steps supported by a statistical framework. Software is supplied for creation of scoring applications in different performance evaluation settings. We demonstrate the POS-T by evaluation of CO2 emissions reduction amongst 36 OECD member countries.
BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling
Authors: Bradbury Melissa , Borràs Eva , Castellví Josep , Méndez Olga , Sánchez-Iglesias José Luis , Pérez-Benavente Assumpció , Gil-Moreno Antonio , Sabidó Eduard , Santamaria Anna 
Published: March 2022

AbstractDespite recent advances in the management of BRCA1 mutated high-grade serous ovarian cancer (HGSC), the physiology of these tumors remains poorly understood. Here we provide a comprehensive molecular understanding of the signaling processes that drive HGSC pathogenesis with the addition of valuable ubiquitination profiling, and their dependency on BRCA1 mutation-state directly in patient-derived tissues. Using a multilayered proteomic approach, we show the tight coordination between the ubiquitination and phosphorylation regulatory layers and their role in key cellular processes related to BRCA1-dependent HGSC pathogenesis. In addition, we identify key bridging proteins, kinase activity, and post-translational modifications responsible for molding distinct cancer phenotypes, thus providing new opportunities for therapeutic intervention, and ultimately advance towards a more personalized patient care.
Temperature-responsive mixed-mode column for the modulation of multiple interactions
Authors: Nagase Kenichi , Matsumoto Kosuke , Kanazawa Hideko 
Published: March 2022

AbstractIn this study, mixed-mode chromatography columns have been investigated using multiple analyte interactions. A mixed-mode chromatography column was developed using poly(N-isopropylacrylamide) (PNIPAAm) brush-modified silica beads and poly(3-acrylamidopropyl trimethylammonium chloride) (PAPTAC) brush-modified silica beads. PNIPAAm brush-modified silica beads and PAPTAC brush-modified silica beads were prepared by atom transfer radical polymerization. The beads were then packed into a stainless-steel column in arbitrary compositions. The elution studies evaluated the column performance on hydrophobic, electrostatic, and therapeutic drug samples using steroids, adenosine nucleotide, and antiepileptic drugs as analytes, respectively. Steroids exhibited an increased retention time when the column temperature was increased. The retention of adenosine nucleotides increased with the increasing composition of the PAPTAC-modified beads in the column. The antiepileptic drugs were separated using the prepared mixed-mode columns. An effective separation of antiepileptic drugs was observed on a 10:1 PNIPAAm:PAPTAC column because the balance between the hydrophobic and electrostatic interactions with antiepileptic drugs was optimized for the bead composition. Oligonucleotides were also separated using mixed-mode columns through multiple hydrophobic and electrostatic interactions. These results demonstrate that the developed mixed-mode column can modulate multiple hydrophobic and electrostatic interactions by changing the column temperature and composition of the packed PNIPAAm and PAPTAC beads.
Stereoisomer-dependent conversion of dinaphthothienothiophene precursor films
Authors: Shioya Nobutaka , Fujii Masamichi , Shimoaka Takafumi , Eda Kazuo , Hasegawa Takeshi 
Published: March 2022

AbstractSoluble precursor materials of organic semiconductors are employed for fabricating solution-processable thin film devices. While the so-called precursor approach has already been tried for various organic electronic devices such as transistors and solar cells, understanding of the conversion process in the film lags far behind. Here, we report that molecular aggregation of the precursor compound significantly influences the thermal conversion reaction in the film. For this study, two stereoisomers of a dinaphthothienothiophene (DNTT) precursor that are the endo- and exo-DNTT-phenylmaleimide monoadducts are focused on. The structural change during the thermal conversion process has been investigated by a combination of infrared spectroscopy and X-ray diffraction techniques. The results show that the endo-isomer is readily converted to DNTT in the film by heating, whereas the exo-isomer exhibits no reaction at all. This reaction suppression is found to be due to the self-aggregation property of the exo-isomer accompanying the intermolecular C–H$$\cdots$$
⋯
O interactions. This finding shows a new direction of controlling the on-surface reaction, as well as the importance of analyzing the film structure at the initial stage of the reaction.
Disrupted connectivity in the olfactory bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in Alzheimer’s disease model
Authors: Salimi Morteza , Tabasi Farhad , Abdolsamadi Maryam , Dehghan Samaneh , Dehdar Kolsoum , Nazari Milad , Javan Mohammad , Mirnajafi-Zadeh Javad , Raoufy Mohammad Reza 
Published: March 2022

AbstractNeural synchrony in brain circuits is the mainstay of cognition, including memory processes. Alzheimer's disease (AD) is a progressive neurodegenerative disorder that disrupts neural synchrony in specific circuits, associated with memory dysfunction before a substantial neural loss. Recognition memory impairment is a prominent cognitive symptom in the early stages of AD. The entorhinal–hippocampal circuit is critically engaged in recognition memory and is known as one of the earliest circuits involved due to AD pathology. Notably, the olfactory bulb is closely connected with the entorhinal–hippocampal circuit and is suggested as one of the earliest regions affected by AD. Therefore, we recorded simultaneous local field potential from the olfactory bulb (OB), entorhinal cortex (EC), and dorsal hippocampus (dHPC) to explore the functional connectivity in the OB-EC-dHPC circuit during novel object recognition (NOR) task performance in a rat model of AD. Animals that received amyloid-beta (Aβ) showed a significant impairment in task performance and a marked reduction in OB survived cells. We revealed that Aβ reduced coherence and synchrony in the OB-EC-dHPC circuit at theta and gamma bands during NOR performance. Importantly, our results exhibit that disrupted functional connectivity in the OB-EC-dHPC circuit was correlated with impaired recognition memory induced by Aβ. These findings can elucidate dynamic changes in neural activities underlying AD, helping to find novel diagnostic and therapeutic targets.
Risk subtyping and prognostic assessment of prostate cancer based on consensus genes
Authors: Meng Jialin , Guan Yu , Wang Bijun , Chen Lei , Chen Junyi , Zhang Meng , Liang Chaozhao 
Published: March 2022

AbstractProstate cancer (PCa) is the most frequent malignancy in male urogenital system around worldwide. We performed molecular subtyping and prognostic assessment based on consensus genes in patients with PCa. Five cohorts containing 1,046 PCa patients with RNA expression profiles and recorded clinical follow-up information were included. Univariate, multivariate Cox regression analysis and least absolute shrinkage and selection operator (LASSO) Cox regression were used to select prognostic genes and establish the signature. Immunohistochemistry staining, cell proliferation, migration and invasion assays were used to assess the biological functions of key genes. Thirty-nine intersecting consensus prognostic genes from five independent cohorts were identified. Subsequently, an eleven-consensus-gene classifier was established. In addition, multivariate Cox regression analyses showed that the classifier served as an independent indicator of recurrence-free survival in three of the five cohorts. Combined receiver operating characteristic (ROC) analysis achieved synthesized effects by combining the classifier with clinicopathological features in four of five cohorts. SRD5A2 inhibits cell proliferation, while ITGA11 promotes cell migration and invasion, possibly through the PI3K/AKT signaling pathway. To conclude, we established and validated an eleven-consensus-gene classifier, which may add prognostic value to the currently available staging system.
Non-obligate pairwise metabolite cross-feeding suggests ammensalic interactions between Bacillus amyloliquefaciens and Aspergillus oryzae
Authors: Singh Digar , Lee Sang Hee , Lee Choong Hwan 
Published: March 2022

AbstractBacterial-fungal metabolite trade-offs determine their ecological interactions. We designed a non-obligate pairwise metabolite cross-feeding (MCF) between Bacillus amyloliquefaciens and Aspergillus oryzae. Cross-feeding Aspergillus metabolites (MCF-1) affected higher growth and biofilm formation in Bacillus. LC-MS/MS-based multivariate analyses (MVA) showed variations in the endogenous metabolite profiles between the cross-fed and control Bacillus. We observed and validated that Aspergillus-derived oxylipins were rapidly depleted in Bacillus cultures concomitant with lowered secretion of cyclic lipopeptides (CLPs). Conversely, Bacillus extracts cross-fed to Aspergillus (MCF-2) diminished its mycelial growth and conidiation. Fungistatic effects of Bacillus-derived cyclic surfactins were temporally reduced following their hydrolytic linearization. MVA highlighted disparity between the cross-fed (MCF-2) and control Aspergillus cultures with marked variations in the oxylipin levels. We conclude that the pairwise MCF selectively benefitted Bacillus while suppressing Aspergillus, which suggests their ammensalic interaction. Widening this experimental pipeline across tailored communities may help model and simulate BFIs in more complex microbiomes.
Young Adults With Acquired Brain Injury Show Longitudinal Improvements in Cognition After Intensive Cognitive Rehabilitation
Authors: Gilmore Natalie , Mirman Daniel , Kiran Swathi 
Published: March 2022

Purpose:
The aim of this study was to assess the effect of an intensive cognitive and communication rehabilitation (ICCR) program on language and other cognitive performance in young adults with acquired brain injury (ABI).

Method:

Thirty young adults with chronic ABI participated in this study. Treatment participants (
n
= 22) attended ICCR 6 hours/day, 4 days/week for at least one 12-week semester. Deferred treatment/usual care control participants (
n
= 14) were evaluated before and after at least one 12-week semester. Pre- and postsemester standardized cognitive assessment items were assigned to subdomains. Between-groups and within-group generalized linear mixed-effects models assessed the effect of time point on overall item accuracy and differences by item subdomain. Subdomain analyses were adjusted for multiple comparisons.

Results:
Between-groups analyses revealed that treatment participants improved significantly faster over time than deferred treatment/usual care participants in overall item accuracy and specifically on items in the verbal expression subdomain. Investigating the three-way interaction between time point, group, and etiology revealed that the overall effects of the treatment were similar for individuals with nontraumatic and traumatic brain injuries. The treatment group showed an overall effect of treatment and significant gains over time in the verbal expression, written expression, memory, and problem solving subdomains. The control group did not significantly improve over time on overall item accuracy and showed significant subdomain-level gains in auditory comprehension, which did not survive correction.

Conclusions:
Sustaining an ABI in young adulthood can significantly disrupt key developmental milestones, such as attending college and launching a career. This study provides strong evidence that integrating impairment-based retraining of language and other cognitive skills with “real-world” application in academically focused activities promotes gains in underlying cognitive processes that are important for academic success as measured by standardized assessment items. These findings may prompt a revision to the current continuum of rehabilitative care for young adults with ABI.

Supplemental Material:

https://doi.org/10.23641/asha.19320068
Creating Clinical Research Impact Through Social Media: Five Easy Steps to Get Started
Authors: Davidson Meghan M. , Mahendra Nidhi , Nicholson Nannette 
Published: March 2022

Purpose:
The purpose of this tutorial is to provide a brief tutorial on how to get started with creating clinical impact of research through the use of varied social media channels.

Method:
We summarize the literature and provide examples for creating social media content for clinical research impact.

Results:
We describe a five-step process for creating clinical impact: (a) identify your goal or purpose of creating impact for a specific project, (b) identify your target audience and match it to a social media platform, (c) study benchmark posts made by active users and influencers on your social media outlet of interest, (d) create novel and engaging content, and (e) share content and track responses.

Conclusions:
Creating clinical impact of research through social media does not have to be overwhelming or time consuming and is an important part of disseminating research evidence to help bridge the research-to-practice gap. Readers will be able to share their work on social media to begin creating clinical impact because of reading this tutorial.
Integrating Family-Centered Care Into Chronic Dysphagia Management: A Tutorial
Authors: Shune Samantha E. , Linville Deanna , Namasivayam-MacDonald Ashwini 
Published: March 2022

Purpose:
Chronic illnesses and sources of disability, such as dysphagia, are experienced by the entire family system. A narrow focus on impairment-level treatment cannot account for the often-dramatic shift in biopsychosocial functioning that is experienced by both the individual with dysphagia and their family members. To maximize treatment effectiveness, it is therefore necessary to focus more holistically on family resilience and adaptation. Drawing from the principles of family systems theory and the biopsychosocial–spiritual framework, this tutorial explores the application of family-centered care models to chronic dysphagia management. Using a case study to illustrate dysphagia's impact on family caregivers, we suggest a number of opportunities for speech-language pathologists to appropriately engage in family-centered care.

Conclusions:
Clinicians need to recognize that chronic dysphagia's widespread consequences necessitate the integration of the family into intervention plans. This requires a better understanding of family dynamics, particularly as they relate to the medical condition. As part of the management process, clinicians should consider explicitly inquiring about specific sources of support the family may require and make referrals to other professionals as needed. They should also consider implementing strategies to support the family into intervention in a way that minimizes burden and respects their capabilities. It is only through a more family-centered care approach that clinicians will be able to reduce the impacts of third-party disability and improve the lives of patients and their families.
Radio resource allocation for multi‐antenna gateway stations of diverse NGSO constellation networks
Authors: Ren Zixuan , Li Wei , Jin Jin , Zhan Yafeng 
Published: March 2022

AbstractWith the rapid development of NGSO satellite constellation, multi‐antenna gateway station has become a trend to increase the capacity of communication system. Since the wide use of Ku/Ka bands as well as the dynamic characteristics of NGSO networks, the co‐frequency interference between constellations is inevitable, and the interference limits become important constraints to the system capacity of multi‐antenna gateway stations. In this paper, the allocation of radio resources, including power and beam, under the interference constraints is formulated as an optimization problem. However, traditional optimization methods may not be suitable for NGSO satellite coexistence scenarios due to the fast movements of NGSO satellites. In order to address this problem, the optimization problem is transformed into two subproblems, and a Jensen's Inequality‐based Fast Iteration (JI‐FI) algorithm is designed to solve both of them iteratively. Simulation results show that the interference can be effectively reduced to the value below the threshold and beam and power resources can be allocated simultaneously by adopting the proposed algorithm. Compared with the traditional methods, the proposed scheme can significantly improve the system capacity by more than 25%, and it can greatly reduce the computational complexity.
Yet another star in the Albireo system
Authors: Jack D. , Schröder K.-P. , Mittag M. , Bastian U. 
Published: March 2022

Context. Albireo is a well-known bright visual double star. It is still unclear if the components A and B form a gravitationally bound system. The component Albireo A is itself a binary star. The orbital parameters of the Albireo Aa, Ac system have been determined only recently. Thus, Albireo is still of interest for current research.
Aims. We aim to present evidence for the detection of a new member in the Albireo system. Furthermore, we aim to determine the orbital parameters and to find further conclusions for the Albireo system.
Methods. We used spectroscopic observations of Albireo A obtained with the TIGRE telescope and determined the radial velocities during a period of over three years. We analyzed the radial velocity curve with RadVel to determine the orbital parameters. In addition, we determined the stellar parameters of Albireo Aa with iSpec.
Results. We found clear evidence for yet another star in the Albireo system orbiting Albireo Aa with a period of about P = 371 days. Several alternative explanations for the periodic radial velocity signal could be discarded. The new companion Albireo Ad is a low mass star of about 0.085 M⊙.
Conclusions. We conclude that Albireo is a hierarchical multiple star system and remains an interesting object for future observations and studies.
Adipositas und Typ-2-Diabetes im Kindes- und Jugendalter
Authors: Pappa Angeliki 
Published: March 2022

ZusammenfassungÜbergewicht, Adipositas und die assoziierten Folgeerkrankungen sind ein ernstzunehmendes Problem für die Gesundheit von Kindern und Jugendlichen. Bereits jetzt ist jedes 6. Kind in Deutschland übergewichtig oder adipös. Die Folgen sind häufig Leid für die Betroffenen und ihre Familien und Belastungen für das Gesundheitssystem durch nachfolgende Krankheiten wie Bluthochdruck, metabolisches Syndrom auch mit Fettlebererkrankung und Typ-2-Diabetes. Auf diese Entwicklung wirkte die Corona-Pandemie unter mehreren Aspekten als Beschleuniger.
Möglichkeiten der Adipositastherapie in Deutschland
Authors: Holzapfel Christina 
Published: March 2022

ZusammenfassungAdipositas ist eine der größten gesamtgesellschaftlichen Herausforderungen mit vielen Begleit- und Folgeerkrankungen. Voraussetzung für eine Gewichtsreduktion ist eine negative Energiebilanz, d. h. Menschen verbrauchen mehr Energie, als sie über Nahrungsmittel und Getränke zu sich nehmen. Im deutschen Gesundheitssystem ist Adipositas nicht als Erkrankung anerkannt. Es ist daher dringend nötig, Strukturen zu schaffen, die die Therapie verbessern und den Betroffenen den Zugang zu einem gesundheitsförderlichen Lebensstil erleichtern.
Chronisch-entzündliche Darmerkrankungen
Authors: Atreya Raja , Neurath Markus Friedrich 
Published: March 2022

Was ist neu?
Chirurgische Therapie Die Auswertung von Langzeitdaten bestätigt die Gleichwertigkeit der primär chirurgischen vs. medikamentösen (Infliximab) Therapie bei Morbus-Crohn-Patienten mit isoliertem Ileozökalbefall.
Neu zugelassene und sich in später klinischer Entwicklung befindliche Therapien Der selektive JAK-1-Inhibitor Filgotinib ist kürzlich zur Behandlung von Colitis-ulcerosa-Patienten mit mittelschwerer bis schwerer Aktivität zugelassen worden, welche auf eine konventionelle oder biologische Therapie nicht angesprochen haben. Weiterhin ist der S1P-Rezeptor-Modulator Ozanimod, welcher den Abstrom von Lymphozyten aus dem Lymphknoten verhindert, ebenfalls zur Behandlung der genannten Colitis-ulcerosa-Patienten zugelassen worden. Der S1P-Rezeptor-Modulator Etrasimod wird aktuell in einer klinischen Phase-3-Studie bei Colitis ulcerosa getestet und der selektive JAK-1-Inhibitor Upadacitinib dürfte nächstes Jahr bei Colitis ulcerosa zugelassen werden. Zahlreiche IL-23p19-Inhibitoren befinden sich in fortgeschrittenen Studienphasen (Guselkumab, Mirikizumab, Brazikumab) bzw. haben diese bereits beendet (Risankizumab). Deren Zulassung ist zeitnah zu erwarten. Der lokal applizierbare Toll-like-Rezeptor-9-Agonist Cobitolimod könnte zukünftig eine lokal applizierbare Therapieoption bei Patienten mit linksseitiger Colitis ulcerosa darstellen.
Zukünftige therapeutische Herausforderungen Die Positionierung der bereits vorhandenen und zukünftigen Therapieoptionen in unseren Therapiealgorithmus muss noch definiert werden. Hierbei können wir auf Ergebnisse erster Head-to-Head-Studien zurückgreifen und sollten darüber hinaus bei jedem Patienten individuelle Faktoren berücksichtigen. Noch immer fehlen Prädiktoren für die Vorhersage des individuellen Therapieansprechens.
Arthrose – neue therapeutische Ansätze
Authors: Krasselt Marco , Baerwald Christoph 
Published: March 2022

Was ist neu?
Epidemiologie und pathophysiologische Aspekte Die Arthrose ist eine sehr häufige Erkrankung, deren Prävalenz aufgrund der älter werdenden Gesellschaft weiter zunehmen wird. Pathogenetisch sind neben dem Alter auch Traumata, Fehlbelastungen und Übergewicht Risikofaktoren. In den Fokus gerückt sind in den letzten Jahren sowohl die Zellalterung (Seneszenz), als auch das Übergewicht. Beide Risikofaktoren können – unabhängig von einer rein mechanischen Betrachtungsweise – eine Inflammation im Gelenk begünstigen: sowohl seneszente Chondrozyten als auch Adipozyten können vermehrt inflammatorische Zytokine produzieren.
Therapie Neben der Aufklärung über die Natur und den Verlauf der Erkrankung bilden vor allem körperliche Aktivität und eine Gewichtsreduktion die Eckpfeiler der Therapie. Schmerztherapeutisch können NSAR empfohlen werden, allerdings sind hier die im Alltag sehr häufigen Kontraindikationen zu beachten. Alternativ können Paracetamol oder niedrigpotente Opioide wie z. B. Tramadol erwogen werden. Topische NSAR-Formulierungen und intraartikuläre Glukokortikoidgaben können insbesondere bei der Gonarthrose zu einer Schmerzreduktion beitragen. Für Nahrungsergänzungsmittel mit Chondroitin oder Glycosaminoglycane kann weiterhin keine generelle Empfehlung gegeben werden, sie sollten allenfalls begleitend zum Einsatz kommen. Mit der aktuellen Nichtzulassung des Nerve-Growth-Factor-(NGF)-Antikörpers Tanezumab sind neue medikamentöse Ansätze wieder in die Ferne gerückt. Leider sind auch die Ergebnisse der Phase II-Studie zum Wnt-Inhibitor Lorecivivint wenig ermutigend; hier stehen allerdings die Daten der Phase-III-Studie noch aus.