bluuebunny/crossref_metadata_2025_split huggingface dataset:
Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors
Authors: Patoori Sruti , Barnada Samantha M. , Large Christopher , Murray John I. , Trizzino Marco 
Published: September 2022

ABSTRACT
The hippocampus is associated with essential brain functions, such as learning and memory. Human hippocampal volume is significantly greater than expected compared with that of non-human apes, suggesting a recent expansion. Intermediate progenitors, which are able to undergo multiple rounds of proliferative division before a final neurogenic division, may have played a role in evolutionary hippocampal expansion. To investigate the evolution of gene regulatory networks underpinning hippocampal neurogenesis in apes, we leveraged the differentiation of human and chimpanzee induced pluripotent stem cells into TBR2 (or EOMES)-positive hippocampal intermediate progenitor cells (hpIPCs). We found that the gene networks active in hpIPCs are significantly different between humans and chimpanzees, with ∼2500 genes being differentially expressed. We demonstrate that species-specific transposon-derived enhancers contribute to these transcriptomic differences. Young transposons, predominantly endogenous retroviruses and SINE-Vntr-Alus (SVAs), were co-opted as enhancers in a species-specific manner. Human-specific SVAs provided substrates for thousands of novel TBR2-binding sites, and CRISPR-mediated repression of these SVAs attenuated the expression of ∼25% of the genes that are upregulated in human intermediate progenitors relative to the same cell population in the chimpanzee.
Trim33 conditions the lifespan of primitive macrophages and onset of definitive macrophage production
Authors: Lou Demy Doris , Touret Anne-Lou , Lancino Mylène , Tauzin Muriel , Capuana Lavinia , Pierre Constance , Herbomel Philippe 
Published: September 2022

ABSTRACT
Trim33 (Tif1γ) is a transcriptional regulator that is notably involved in several aspects of hematopoiesis. It is essential for the production of erythrocytes in zebrafish, and for the proper functioning and aging of hematopoietic stem and progenitor cells (HSPCs) in mice. Here, we have found that, in zebrafish development, Trim33 is essential cell-autonomously for the lifespan of the yolk sac-derived primitive macrophages, as well as for the initial production of definitive (HSPC-derived) macrophages in the first niche of definitive hematopoiesis, the caudal hematopoietic tissue. Moreover, Trim33 deficiency leads to an excess production of definitive neutrophils and thrombocytes. Our data indicate that Trim33 radically conditions the differentiation output of aorta-derived HSPCs in all four erythro-myeloid cell types, in a niche-specific manner.
Influence of physical activity, diet, psychic stress and other diseases on psoriaris
Authors: Spozowski Karol , Powroźniak Ewelina , Raksa Karolina , Czarkowski Marcin , Oleksa Paulina 
Published: September 2022

Introduction and objective: Psoriasis is a chronic inflammatory skin disease characterized by improperly differentiating epidermal keratinocytes. It may be associated with many coexisting diseases, mainly of the digestive, circulatory and autoimmune systems.
Materials and methods: Pubmed database was searched. The criteria for qualifying the articl for the review were the following keywords: psoriasis, diet, sport, exercises, stress. 20 articles from 2017 to 2022 were analyzed.
Description of the state of knowledge: Psoriasis has many links with metabolism, which depends on diet, exercise, and other diseases in the body. The excessive amount of pro-inflammatory substances can be regulated by supplying the body with anti-inflammatory ingredients in the diet as well as by physical activity that reduces the level of visceral fat. Many other diseases related to, inter alia, inflammation of the intestines or the state of the intestinal microbiota also affect the systemic distribution of cytokines and adipokines. An important factor influencing health is also mental stress and even epigenetic factors.
Summary: Increased physical activity helps fight the main consequences of psoriasis. A similar effect is demonstrated by a low-calorie diet with a high content of anti-inflammatory ingredients and antioxidants and avoidance of pro-inflammatory substances. Treating other comorbidities and maintaining a low level of mental stress also have a positive effect on patients with psoriasis. All of the above interventions are effective complementary to pharmacological therapy.
Shinrin-yoku and its role in hypertension therapy
Authors: Rybak Natalia , Czarnota Jakub , Dobrzyński Michał , Skubel Tomasz 
Published: September 2022

Objective: This study aimed to evaluate the potential role of Shinrin-yoku (forest bathing) in the therapy of hypertension.

Methods and materials: A literature search was conducted in the PubMed MEADLINE
database of medical publications using the following keywords: Shinrin-yoku, forest bathing, hypertension, phytoncides

Results: Hypertension is a serious problem in the Polish population. The data from the National Health Fund show that in 2020 almost 10 million adult Poles were affected by this disease, and over 14% of the entire pharmacy reimbursement budget was used to reimburse drugs for hypertension.
Primary arterial hypertension is caused by a mixture of environmental and genetic factors, including obesity, mental stress, low physical activity, and excessive sodium intake. Although hypertension is usually asymptomatic, it contributes to serious complications such as left ventricular hypertrophy, impaired renal function, changes in the vessels of the retina, and finally to stroke or aortic dissection.
The Shinrin-yoku (forest bathing) is becoming a worldwide recognized method used in preventative medicine and can play a substantial role in decreasing the number of patients suffering from hypertension.

Conclusion: Shinrin-yoku (forest bathing) lowers blood pressure, heart rate, and the level of stress hormones, and therefore can be a prophylactic element in preventing the development of hypertension or an element of non-pharmacological therapy for this disease entity. Additionally, it has a positive effect on the immune system.
DYNAMICS OF KNOWLEDGE FLOWS: GEOGRAPHICAL PROXIMITY, VERTICAL RELATIONS AND LEARNING BY INTERACTION
Authors: Ruffoni Janaina , Suzigan Wilson , Tatsch Ana Lucia 
Published: September 2022

O objetio do artigo é compreender as fontes de conhecimento e os processos de aprendizagem que sustentam as inovações das firmas localizadas em Sistemas Locais de Produção (SLP). A principal contribuição é empírica. Foram pesquisados dois SLP do segmento de máquinas para calçados no final dos anos 2000, período em que já era observado o processo de mudança concorrencial com a entrada de empresas chinesas como concorrentes diretas das firmas analisadas. Adotou-se a lógica de que a geração da inovação é influenciada pelo aprendizado e pela interação da firma. A pesquisa de campo foi realizada com questionário estruturado e com entrevistas in loco, tanto na Itália quanto no Brasil. Em termos de resultados, destacam-se que: as relações verticais são mais frequentes quando comparadas às horizontais; o aprendizado por interação explica a geração de inovação; e a proximidade geográfica é importante para explicar as redes de conhecimento. Os resultados são consistentes com o padrão setorial identificado como fornecedor especializado.
Metallothionein levels on the gill and liver of Mystus nigriceps (Valenciennes, 1840) in Welang River, Pasuruan City, East Java
Authors: Wardani Lisma , Herawati Endang Yuli , Surya Asus Maizar 
Published: September 2022

This research was conducted in October 2021 using a survey method. Sampling was carried out three times with a span of every 2 weeks at 3 stations along the lower reaches of the Welang River Pasuruan Regency. Parameters observed included cadmium metal content in fish gills and liver, metallothionein levels in gills, and liver of M. nigriceps. Fish and the relationship between cadmium metal and metallothionein levels in the gills and liver of M. nigriceps in the Welang River. The average yield of cadmium metal content in the gills of M. nigriceps is 5.943-8.103 mg/l. Meanwhile, the average result of heavy metal content in the liver of M. nigriceps is 6.397-9.997 mg/l. Measurement of metallothionein levels showed that the average level of metallothionein in the gills of M. nigriceps was 5.860-8.688 ng/mL. Meanwhile, the average level of metallothionein in the liver of M. nigriceps is 7.110-8.334 ng/mL. And the results of the linear regression test showed that the average content of cadmium in the gills and liver with the average metallothionein levels in the gills and liver of catfish was significantly correlated.
Temperature and strain sensitivities of a groove bonded fiber Bragg grating at room and cryogenic temperatures
Authors: Huang Xiyong , Davies Mike , Moseley Dominic A. , Salazar Erica E. , Sanabria Charlie , Duke Owen , Ludbrook Bart M. , Badcock Rodney A. 
Published: September 2022

Optical fiber Bragg gratings (FBGs) are well suited for applications as temperature or/and strain sensors in harsh environments, e.g., detecting thermal hot spots in high-temperature superconductor (HTS) fusion energy magnets at cryogenic temperatures and high radiation environments. To maximize the signal-to-noise ratio (SNR) of the FBGs to a hot spot, we propose to have them mounted in V-shaped grooves of HTS’ copper former. To investigate the differences between different adhesives on transferring strain and heat in this configuration, five arrays of FBGs are mounted in the V-shaped grooves of a copper dog-bone using Scotch-Weld epoxy, Stycast 2850 FT, Apiezon N, and Loctite 5145 silicone. The copper is cycled through tensile forces in a modified universal tensile tester, subjected to a thermal cycle between 293 K and 77 K, and exposed to heat pulse propagations at 293 K and 80 K. The FBGs that are bonded using Stycast show the highest temperature and strain sensitivities at room and cryogenic temperatures. No major differences in the temperature and strain sensitivities have been found between Ormocer and polyimide coated FBGs. Apiezon N is found to transfer strain consistently well below 245 K, which is comparable with other bonding materials in the temperature range between 77 K and 110 K. The FBGs bonded with the four adhesives in the V-groove configurations are shown to have comparable SNRs to a temperature rise of 20 K at 80 K. This paper emphasizes the importance of maximizing the thermal strain transferred from the host material through the bonding agents to achieve high temperature sensitivity of FBGs.
Health-related quality of life and associated factors among adult podoconiosis patients in Debre Elias district Northwest, Ethiopia
Authors: Abebaw Abraham , Atnafu Asmamaw , Worku Nigusu , Hagos Asebe 
Published: September 2022

Background
Podoconiosis is endemic non-filarial elephantiasis and non-infective neglected tropical disease. It has a wide impact on the physical, social and psychological aspects of the well-being of a person. However, limited information is available about the disease burden on health-related quality of life and associated factors in Ethiopia.

Objective
This study aimed is to determine health-related quality of life and associated factors among adult podoconiosis patients in Debre Elias district, Northwest, Ethiopia.

Methods
A community-based cross-sectional study was conducted from February 1 to March 30, 2020 in the Debre Elias district. A multi-stage stratified; systematic random sampling technique was employed to select 403 podoconiosis patients. The data were collected through an interviewer-administered questionnaire. Data were entered into Epi data version 4.6 and exported to STATA version 14 for analysis. After the assumption check for the linear regression model, simple and multiple regression was done to see the association between the predictor and outcome variables. Predictor variables that had p-value <0.2 at simple linear regression were taken into multiple linear regression. β coefficient with 95% CI and p-value of <0.05 was considered as statistically significant variables in multiple linear regression analysis.

Result
The overall mean quality of life score among podoconiosis patients was 61.93±17.14. The mean quality of life score for the physical, psychological, social, and environmental domains were 75.57±21.86, 60.43±18.58, 30.34±10.46, and 81.38±22.77 respectively. Foot care had a statically significant association with all domains. Higher quality of life podoconiosis patients was associated with foot care. Lower quality of life was associated with the presence of anxiety, advanced stage of the disease, and frequent adenolymphangitis attack.

Conclusion
Social and psychological domains of quality of life were lowest as compared to physical and environmental domains of quality of life. Early medical treatment, psychosocial support, and home-based foot care should be encouraged to improve the quality of life in podoconiosis patients.
Perceived health literacy and COVID-19 vaccine acceptance among Chinese college students: A mediation analysis
Authors: Jiang Fangfang , Zhao Yang , Bai Jianling , Yang Xueying , Zhang Jiajia , Lin Danhua , Li Xiaoming 
Published: September 2022

Background
Although COVID-19 vaccines hold the potential to dramatically alter the COVID-19 pandemic, vaccine hesitancy remains a serious threat to the management and control of COVID-19 infections. Vaccination of young adults plays a crucial role in achieving herd immunity. However, the determinants of COVID-19 vaccine acceptance among the youth in China have not been fully explored. Our study aims to investigate the direct and indirect effects of perceived health literacy on COVID-19 vaccine acceptance.

Methods
This survey was conducted among Chinese college students during September and October, 2020. COVID-19 vaccine acceptance was defined as the likelihood that participants would get a COVID-19 vaccine. A mediation analysis was employed to explore the direct and indirect effects of perceived health literacy on COVID-19 vaccine acceptance.

Results
A total of 2,587 college students were included in our study. The results of the survey revealed that the majority (80.40%) of the participants expressed high COVID-19 vaccine acceptance. After controlling for demographic characteristics, the relationship between perceived health literacy and COVID-19 vaccine acceptance was mediated by positive attitudes toward general vaccination (std.β = 0.004, p = 0.037) and self-efficacy of COVID-19 vaccine (std.β = 0.053, p < 0.001).

Conclusions
The findings suggest that interventions targeting health literacy to promote COVID-19 vaccination coverage might consider placing greater emphasis on enhancing the positive attitude towards and self-efficacy of vaccines among youth.
Prevalence and factors associated with anaemia in children aged 6–24 months living a high malaria transmission setting in Burundi
Authors: Nkurunziza Jean Claude , Nabukeera-Barungi Nicolette , Kalyango Joan Nakayaga , Niyongabo Aloys , Mwanja Mercy Muwema , Mupere Ezekiel , Nankabirwa Joaniter I. 
Published: September 2022

BackgroundIn very young children, anaemia has been linked to increased morbidity, mortality and poor cognitive development. Although Burundi has a high burden of anaemia, which may be worsened by the high burden of malaria, little is known about the extent of the problem in very young children who are most at risk of severe disease. We estimated the prevalence, and assessed the factors associated with anaemia in children aged 6–24 months using baseline data collected as part of an on-going study evaluating the effect of Micronutrient supplementation on anaemia and cognition among children in high malaria transmission settings in Burundi.MethodsBetween February and March 2020, surveys were conducted in 498 households within the catchment area of Mukenke Health Center. One child aged 6–24 months was selected per household to participate in the survey. Following written informed consent, we administered a questionnaire to the child’s primary caregiver to capture information on child’s demographics, nutritional status, food intake, health (status, and morbidity and treatment-seeking practices), as well as the household markers of wealth. A physical exam was conducted, and a blood sample was collected to: 1) assess for presence of plasmodium infection using a rapid diagnosis test; 2) estimate the haemoglobin levels using a portable haemocue machine. A stool sample was also collected to examine for the presence of helminth infections.ResultsThe prevalence of anaemia was 74.3% (95% confidence interval [CI] 61.5%-84.0%), with most of the anaemic study participants classified as having moderate anaemia (59.2%). A total of 62 (12.5%) participants had positive malaria rapid diagnosis tests. Factors significantly associated with higher odds of developing anaemia included not receiving deworming medication (adjusted Odd ratio [aOR] = 3.54, 95% CI 1.79–6.99, p<0.001), the child’s home location (Mukenke II: aOR = 2.22, 95% CI 1.89–2.62, p<0.001; Mukenke: aOR = 2.76, 95% CI 2.46–3.10, p<0.001 and Budahunga: aOR = 3.12, 95% CI 2. 94–3.31, p<0.001) and the child’s age group (Children aged 6–11 months: aOR = 2.27, 95% CI 1.32–3.91, p<0.001). Education level was inversely associated with less odds of anaemia: child’s primary care giver with a secondary (aOR = 0.67; 95% CI: 0.47–0.95, p = 0,024) and tertiary education level (aOR = 0.48; 95% CI: 0.38–0.61, p<0.001).ConclusionAnaemia is highly prevalent among young children in high malaria transmission setting. Anaemia is more prevalent among children who not dewormed and those with malaria. To prevent the long-term adverse outcomes of the anaemia in children, policy makers should focus on improving uptake of the deworming and malaria prevention programs, promote preventive interventions and improve the education of women especially in families with very young children.
Clinical impact of the rapid molecular detection of RSV and influenza A and B viruses in the emergency department
Authors: Yin Nicolas , Van Nuffelen Marc , Bartiaux Magali , Préseau Thierry , Roggen Inge , Delaunoy Sabrina , Mahadeb Bhavna , Dahma Hafid , Busson Laurent , Vandenberg Olivier , Hallin Marie 
Published: September 2022

Introduction
Using respiratory virus rapid diagnostic tests in the emergency department could allow better and faster clinical management. Point-of-care PCR instruments now provide results in less than 30 minutes. The objective of this study was to assess the impact of the use of a rapid molecular diagnostic test, the cobas® Influenza A/B & RSV Assay, during the clinical management of emergency department patients.

Methods
Patients (adults and children) requiring admission or suffering from an underlying condition at risk of respiratory complications were prospectively recruited in the emergency department of four hospitals in the Brussels region. Physicians’ intentions regarding admission, isolation, antibiotic, and antiviral use were collected before and after performing the rapid molecular test. Additionally, a comparison of the analytical performance of this test against antigen rapid tests and viral culture was performed as well as a time-to-result evaluation.

Results
Among the 293 patients recruited, 90 had a positive PCR, whereas 44 had a positive antigen test. PCR yielded a sensitivity of 100% for all targets. Antigen tests yielded sensitivities ranging from 66.7% for influenza B to 83.3% for respiratory syncytial virus (RSV). The use of PCR allowed a decrease in the overall need for isolation and treatment by limiting the isolation of negative patients and antibiotic use for positive patients. Meanwhile, antiviral treatments better targeted patients with a positive influenza PCR.

Conclusion
The use of a rapid influenza and RSV molecular test improves the clinical management of patients admitted to the emergency department by providing a fast and reliable result. Their additional cost compared to antigen tests should be balanced with the benefit of their analytical performance, leading to efficient reductions in the need for isolation and antibiotic use.
Retos a la seguridad humana en Colombia
Authors: Guevara Parra América Celeste 
Published: September 2022

El siglo XXI se ha caracterizado por una multiplicidad de conflictos internos atravesados por un fuerte componente económico que ha hecho de la pobreza la fuente y el catalizador de las amenazas a la seguridad de las comunidades. Este ha sido el caso del conflicto interno colombiano que ha afectado especialmente a la población civil de las zonas rurales periféricas las cuales, además de encarar constantemente a la violencia, deben enfrentarse al hambre, el olvido y la indiferencia del resto de la población, de ahí que sea posible hablar de violencia estructural. Teniendo en cuenta lo anterior, en este artículo se presenta no solo un contexto caracterizado por una diversidad de actores armados que mantienen una lucha constante con el Estado colombiano y donde el narcotráfico ha sido el principal patrocinador de la guerra, sino también se hace referencia a las secuelas y a los costos que ha dejado la violencia política en el tejido social. A modo de conclusión se destaca que, en una situación de guerra interna, si bien el fin de las hostilidades es de gran importancia en términos de seguridad, es sólo uno de los elementos necesarios para la protección de la dignidad e integridad de los colombianos, dicha protección debe incluir también las esferas social, cultural, económica y la acción pública.
PENERAPAN TRADEMARK DILUTION PADA PENEGAKAN PERLINDUNGAN HUKUM HAK MEREK TERKENAL DI INDONESIA
Authors: Roisah Kholis , Setiyono Joko 
Published: September 2022

Penelitian ini bertujuan menganalisa peraturan perlindungan merek terkenal dikaitkan dengan doktrin trademark dilution dan membahas peluang penerapan doktrin trademark dilution dalam penegakan perlindungan hak merek di Indonesia. Metode peneltian yang digunakan yuridis normati dengan pendekatan analisis deskriptif dengan menggunakan data sekunder serta metode analisa digunakan menggunakan analisa kualitatif. Hasil Penelitian menunjukkan bahwa peluang menerapkan doktrin dilusi yaitu pada proses pendaftaran merek dan pada perkara sengketa gugatan pembatalan hak merek. Pemeriksa merek menerapkan doktrin trademark dilution pada waktu melakukan penolakan secara ex-officio ataupun atas permintaan keberataan pemilik merek terkenal terhadap setiap permohonan merek yang mempunyai persamaan dengan merek terkenal untuk pemakaian produk tidak sejenis dengan mempertimbangkan reputasi merek terkenal. Belum ada keputusan hakim Indonesia yang berani menerapkan doktrin trademark dilution dengan alasan penerapan doktrin itikat tidak baik sudah cukup memadai dalam memberikan perlindungan hukum terhadap hak merek terkenal. Ketiadakan aturan tentang trademark dilution yang secara jelas tersurat di dalam Undang Undang Merek menjadi alasan para hakim alasan utama belum bisa menerapkan doktrin trademark dilution. Tanpa adanya alasan bluring ataupun tarnisment tujuan untuk menghapuskan tanda merek yang sama ataupun menyerupai oleh pihak lain yang non competitor sudah tercapai.