bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review on efficacy, safety and cost-effectiveness of office-based laryngeal biopsy
Authors: Swaminathan R , Rosa Opatha S , Mughal Z , Prasad S 
Published: June 2022

AbstractObjectiveLaryngeal cancer is the second most prevalent head and neck malignancy in the USA. With recent advances in technology, this procedure is increasingly performed under local anaesthesia. This study aimed to identify the efficacy, safety and cost-effectiveness of laryngeal biopsy in out-patients by conducting a systematic review.MethodA literature search was conducted using PubMed, Medline, Google Scholar and Embase over a 20-year period. Inclusion criteria were: studies performed on out-patient diagnostic biopsy procedures of the larynx. Exclusion criteria included all therapeutic procedures. The outcome measures were sensitivity and specificity, complication rate and cost-savings.ResultsThirty-five studies were included in the analysis. The sensitivity and specificity varied from 60 to 100 per cent with a low complication rate and cost savings.ConclusionOffice-based laryngeal biopsies are increasingly used in the diagnosis of laryngeal cancers, resulting in earlier diagnosis and commencement of treatment. The barrier to undertaking this procedure is low sensitivity.
Can dialectic materialism produce beauty? The “Great Aesthetic Debates” (1956–1962) in the People's Republic of China
Authors: Laikwan Pang 
Published: June 2022

AbstractThis article focuses on a set of aesthetic debates that took place in China in the late 1950s. By exploring the main arguments presented by different thinkers, particularly the writings of Zhu Guanqian and Li Zehou, this article demonstrates how the aesthetics took part in the ideological formation of the new socialist state. From the debates, we observe the tensions between the complexity of the material-political and the reductionism of the state ideology. We also recognize why and how aesthetics could be such an important site of political contestation in this young socialist country, and how the interactions between human senses and the material world are essential to arts universally. The dominant materialist aesthetics presented in the debate was less a theory of things than a theory of the social. This historical materialist approach might be useful as a social critique; however, when handled dogmatically, it not only rejects the autonomy of things, but also disallows art works to reflect the complex human interactions with the material world beyond economic power relations. We can find more sophisticated analysis in Zhu's aesthetic theory, which tries to incorporate the interactions between the subjects and the objects into materialism.
Broadbanding and multi-frequency in dielectric resonator antennas: a comprehensive review
Authors: Bhattacharya (Mitra) Sriparna , Ray Sekhar Chandra 
Published: June 2022

AbstractDielectric resonator antennas (DRAs) are developed antennas that are lightweight, wideband, small-sized and have high radiation efficiency. A DRA is an appropriate candidate for any radio communication including radar applications mainly because of its high efficiency and wideband performance. As the development of DRAs has been a continuous process for more than five decades the plethora of the same has become magnificent in all possible ways. Scientists have walked the technical path for more than centuries and tried to meet the various challenges in the most graceful ways. Reduction of loss, lightweight, and desired radiation patterns are some of the issues which are effectively met by DRAs. This paper presents a brief comprehensive review of the state of art techniques, giving an exhaustive idea of achieving broadband and multi-frequency operations in the areas of DRAs. The paper associates the references of the past and correlates with the current and future trends of research in DRAs that could be of immense help to the young upcoming researchers interested in this field.
Identifying Geographical Patterns of Transient Deformation in the Geological Sea Level Record
Authors: Simon K. M. , Riva R. E. M. , Broerse T. 
Published: June 2022

AbstractIn this study, we examine the effect of transient mantle creep on the prediction of glacial isostatic adjustment (GIA) signals. Specifically, we compare predictions of relative sea level (RSL) change from GIA from a set of Earth models in which transient creep parameters are varied in a simple Burgers model to a reference case with a Maxwell viscoelastic rheology. The model predictions are evaluated in two ways: first, relative to each other to quantify the effect of parameter variation, and second, for their ability to reproduce well‐constrained sea level records from selected locations. Both the resolution and geographic location of the RSL observations determine whether the data can distinguish between model cases. Model predictions are most sensitive to the inclusion of transient mantle deformation in regions that are near‐field and peripheral relative to former ice sheets. This sensitivity appears particularly true along the North American west coast in the region of the former Cordilleran Ice Sheet, which experienced rapid sea‐level fall following deglaciation between 14 and 12 kyr BP. Relative to the Maxwell case, Burgers models better reproduce this rapid phase of regional postglacial sea‐level fall. As well, computed goodness‐of‐fit values in this region show a clear preference for models where transient deformation is present in the whole or lower mantle, and for models where the rigidity of the Kelvin element is weakened relative to the rigidity of the Maxwell element. In contrast, model predictions of relative sea‐level change in the far‐field show weak sensitivity to the inclusion of transient deformation.
Role of Ocean and Atmosphere Variability in Scale‐Dependent Thermodynamic Air‐Sea Interactions
Authors: Laurindo Lucas C. , Small R. Justin , Thompson LuAnne , Siqueira Leo , Bryan Frank O. , Chang Ping , Danabasoglu Gokhan , Kamenkovich Igor V. , Kirtman Ben P. , Wang Hong , Zhang Shaoqing 
Published: June 2022

AbstractThis study investigates the influence of oceanic and atmospheric processes in extratropical thermodynamic air‐sea interactions resolved by satellite observations (OBS) and by two climate model simulations run with eddy‐resolving high‐resolution (HR) and eddy‐parameterized low‐resolution (LR) ocean components. Here, spectral methods are used to characterize the sea surface temperature (SST) and turbulent heat flux (THF) variability and co‐variability over scales between 50 and 10,000 km and 60 days to 80 years in the Pacific Ocean. The relative roles of the ocean and atmosphere are interpreted using a stochastic upper‐ocean temperature evolution model forced by noise terms representing intrinsic variability in each medium, defined using climate model data to produce realistic rather than white spectral power density distributions. The analysis of all datasets shows that the atmosphere dominates the SST and THF variability over zonal wavelengths larger than ∼2,000–2,500 km. In HR and OBS, ocean processes dominate the variability of both quantities at scales smaller than the atmospheric first internal Rossby radius of deformation (R1, ∼600–2,000 km) due to a substantial ocean forcing coinciding with a weaker atmospheric modulation of THF (and consequently of SST) than at larger scales. The ocean forcing also induces oscillations in SST and THF with periods ranging from intraseasonal to multidecadal, reflecting a red spectrum response to ocean forcing similar to that driven by atmospheric forcing. Such features are virtually absent in LR due to a weaker ocean forcing relative to HR.
Structural, molecular, and functional insights into Schlafen proteins
Authors: Jo Ukhyun , Pommier Yves 
Published: June 2022

AbstractSchlafen (SLFN) genes belong to a vertebrate gene family encoding proteins with high sequence homology. However, each SLFN is functionally divergent and differentially expressed in various tissues and species, showing a wide range of expression in cancer and normal cells. SLFNs are involved in various cellular and tissue-specific processes, including DNA replication, proliferation, immune and interferon responses, viral infections, and sensitivity to DNA-targeted anticancer agents. The fundamental molecular characteristics of SLFNs and their structures are beginning to be elucidated. Here, we review recent structural insights into the N-terminal, middle and C-terminal domains (N-, M-, and C-domains, respectively) of human SLFNs and discuss the current understanding of their biological roles. We review the distinct molecular activities of SLFN11, SLFN5, and SLFN12 and the relevance of SLFN11 as a predictive biomarker in oncology.
Insights to estimate exposure to regulated and non-regulated disinfection by-products in drinking water
Authors: Redondo-Hasselerharm Paula E. , Cserbik Dora , Flores Cintia , Farré Maria J. , Sanchís Josep , Alcolea Jose A. , Planas Carles , Caixach Josep , Villanueva Cristina M. 
Published: June 2022

Abstract
Background
Knowledge about human exposure and health effects associated with non-routinely monitored disinfection by-products (DBPs) in drinking water is sparse.

Objective
To provide insights to estimate exposure to regulated and non-regulated DBPs in drinking water.

Methods
We collected tap water from homes (N = 42), bottled water (N = 10), filtered tap water with domestic activated carbon jars (N = 6) and reverse osmosis (N = 5), and urine (N = 39) samples of participants from Barcelona, Spain. We analyzed 11 haloacetic acids (HAAs), 4 trihalomethanes (THMs), 4 haloacetonitriles (HANs), 2 haloketones, chlorate, chlorite, and trichloronitromethane in water and HAAs in urine samples. Personal information on water intake and socio-demographics was ascertained in the study population (N = 39) through questionnaires. Statistical models were developed based on THMs as explanatory variables using multivariate linear regression and machine learning techniques to predict non-regulated DBPs.

Results
Chlorate, THMs, HAAs, and HANs were quantified in 98–100% tap water samples with median concentration of 214, 42, 18, and 3.2 μg/L, respectively. Multivariate linear regression models had similar or higher goodness of fit (R2) compared to machine learning models. Multivariate linear models for dichloro-, trichloro-, and bromodichloroacetic acid, dichloroacetonitrile, bromochloroacetonitrile, dibromoacetonitrile, trichloropropnanone, and chlorite showed good predictive ability (R2 = 0.8–0.9) as 80–90% of total variance could be explained by THM concentrations. Activated carbon filters reduced DBP concentrations to a variable extent (27–80%), and reverse osmosis reduced DBP concentrations ≥98%. Only chlorate was detected in bottled water samples (N = 3), with median = 13.0 µg/L. Creatinine-adjusted trichloroacetic acid was the most frequently detected HAA in urine samples (69.2%), and moderately correlated with estimated drinking water intake (r = 0.48).

Significance
Findings provide valuable insights for DBP exposure assessment in epidemiological studies. Validation of predictive models in a larger number of samples and replication in different settings is warranted.

Impact statement
Our study focused on assessing and describing the occurrence of several classes of DBPs in drinking water and developing exposure models of good predictive ability for non-regulated DBPs.
Electrically driven single microwire-based single-mode microlaser
Authors: Zhou Xiangbo , Jiang Mingming , Xu Kai , Liu Maosheng , Sha Shulin , Cao Shuiyan , Kan Caixia , Shi Da Ning 
Published: June 2022

AbstractEngineering the lasing-mode oscillations effectively within a laser cavity is a relatively updated attentive study and perplexing issue in the field of laser physics and applications. Herein, we report a realization of electrically driven single-mode microlaser, which is composed of gallium incorporated zinc oxide microwire (ZnO:Ga MW) with platinum nanoparticles (PtNPs, d ~ 130 nm) covering, a magnesium oxide (MgO) nanofilm, a Pt nanofilm, and a p-type GaN substrate. The laser cavity modes could resonate following the whispering-gallery mode (WGM) among the six side surfaces by total internal reflection, and the single-mode lasing wavelength is centered at 390.5 nm with a linewidth of about 0.18 nm. The cavity quality factor Q is evaluated to about 2169. In the laser structure, the usage of Pt and MgO buffer layers can be utilized to engineer the band alignment of ZnO:Ga/GaN heterojunction, optimize the p-n junction quality and increase the current injection. Thus, the well-designed device structure can seamlessly unite the electron-hole recombination region, the gain medium, and optical microresonator into the PtNPs@ZnO:Ga wire perfectly. Such a single MW microlaser is essentially single-mode regardless of the gain spectral bandwidth. To study the single-mode operation, PtNPs working as superabsorber can engineering the multimode lasing actions of ZnO:Ga MWs even if their dimensions are typically much larger than that of lasing wavelength. Our findings can provide a straightforward and effective scheme to develop single-mode microlaser devices based on one-dimensional wire semiconductors.
Is genetic risk of ADHD mediated via dopaminergic mechanism? A study of functional connectivity in ADHD and pharmacologically challenged healthy volunteers with a genetic risk profile
Authors: Grimm Oliver , Thomä Lara , Kranz Thorsten M. , Reif Andreas 
Published: June 2022

AbstractRecent GWAS allow us to calculate polygenic risk scores for ADHD. At the imaging level, resting-state fMRI analyses have given us valuable insights into changes in connectivity patterns in ADHD patients. However, no study has yet attempted to combine these two different levels of investigation. For this endeavor, we used a dopaminergic challenge fMRI study (L-DOPA) in healthy participants who were genotyped for their ADHD, MDD, schizophrenia, and body height polygenic risk score (PRS) and compared results with a study comparing ADHD patients and healthy controls. Our objective was to evaluate how L-DOPA-induced changes of reward-system-related FC are dependent on the individual polygenic risk score. FMRI imaging was used to evaluate resting-state functional connectivity (FC) of targeted subcortical structures in 27 ADHD patients and matched controls. In a second study, we evaluated the effect of ADHD and non-ADHD PRS in a L-DOPA-based pharmaco-fMRI-challenge in 34 healthy volunteers. The functional connectivity between the putamen and parietal lobe was decreased in ADHD patients. In healthy volunteers, the FC between putamen and parietal lobe was lower in ADHD high genetic risk participants. This direction of connectivity was reversed during L-DOPA challenge. Further findings are described for other dopaminergic subcortical structures. The FC between the putamen and the attention network showed the most consistent change in patients as well as in high-risk participants. Our results suggest that FC of the dorsal attention network is altered in adult ADHD as well as in healthy controls with higher genetic risk.
In-situ study of the impact of temperature and architecture on the interfacial structure of microgels
Authors: Bochenek Steffen , Camerin Fabrizio , Zaccarelli Emanuela , Maestro Armando , Schmidt Maximilian M. , Richtering Walter , Scotti Andrea 
Published: June 2022

AbstractThe structural characterization of microgels at interfaces is fundamental to understand both their 2D phase behavior and their role as stabilizers that enable emulsions to be broken on demand. However, this characterization is usually limited by available experimental techniques, which do not allow a direct investigation at interfaces. To overcome this difficulty, here we employ neutron reflectometry, which allows us to probe the structure and responsiveness of the microgels in-situ at the air-water interface. We investigate two types of microgels with different cross-link density, thus having different softness and deformability, both below and above their volume phase transition temperature, by combining experiments with computer simulations of in silico synthesized microgels. We find that temperature only affects the portion of microgels in water, while the strongest effect of the microgels softness is observed in their ability to protrude into the air. In particular, standard microgels have an apparent contact angle of few degrees, while ultra-low cross-linked microgels form a flat polymeric layer with zero contact angle. Altogether, this study provides an in-depth microscopic description of how different microgel architectures affect their arrangements at interfaces, and will be the foundation for a better understanding of their phase behavior and assembly.
Unraveling the molecular mechanism of MIL-53(Al) crystallization
Authors: Salionov Daniil , Semivrazhskaya Olesya O. , Casati Nicola P. M. , Ranocchiari Marco , Bjelić Saša , Verel René , van Bokhoven Jeroen A. , Sushkevich Vitaly L. 
Published: June 2022

AbstractThe vast structural and chemical diversity of metal−organic frameworks (MOFs) provides the exciting possibility of material’s design with tailored properties for gas separation, storage and catalysis. However, after more than twenty years after first reports introducing MOFs, the discovery and control of their synthesis remains extremely challenging due to the lack of understanding of mechanisms of their nucleation and growth. Progress in deciphering crystallization pathways depends on the possibility to follow conversion of initial reagents to products at the molecular level, which is a particular challenge under solvothermal conditions. The present work introduces a detailed molecular-level mechanism of the formation of MIL-53(Al), unraveled by combining in situ time-resolved high-resolution mass-spectrometry, magic angle spinning nuclear magnetic resonance spectroscopy and X-ray diffraction. In contrast to the general belief, the crystallization of MIL-53 occurs via a solid-solid transformation mechanism, associated with the spontaneous release of monomeric aluminum. The role of DMF hydrolysis products, formate and dimethylamine, is established. Our study emphasizes the complexity of MOF crystallization chemistry, which requires case-by-case investigation using a combination of advanced in situ methods for following the induction period, the nucleation and growth across the time domain.
Host lung microbiota promotes malaria-associated acute respiratory distress syndrome
Authors: Mukherjee Debanjan , Chora Ângelo Ferreira , Lone Jean-Christophe , Ramiro Ricardo S. , Blankenhaus Birte , Serre Karine , Ramirez Mário , Gordo Isabel , Veldhoen Marc , Varga-Weisz Patrick , Mota Maria M. 
Published: June 2022

AbstractSevere malaria can manifest itself with a variety of well-recognized clinical phenotypes that are highly predictive of death – severe anaemia, coma (cerebral malaria), multiple organ failure, and respiratory distress. The reasons why an infected individual develops one pathology rather than another remain poorly understood. Here we use distinct rodent models of infection to show that the host microbiota is a contributing factor for the development of respiratory distress syndrome and host mortality in the context of malaria infections (malaria-associated acute respiratory distress syndrome, MA-ARDS). We show that parasite sequestration in the lung results in sustained immune activation. Subsequent production of the anti-inflammatory cytokine IL-10 by T cells compromises microbial control, leading to severe lung disease. Notably, bacterial clearance with linezolid, an antibiotic commonly used in the clinical setting to control lung-associated bacterial infections, prevents MA-ARDS-associated lethality. Thus, we propose that the host’s anti-inflammatory response to limit tissue damage can result in loss of microbial control, which promotes MA-ARDS. This must be considered when intervening against life-threatening respiratory complications.
Limited effects of m6A modification on mRNA partitioning into stress granules
Authors: Khong Anthony , Matheny Tyler , Huynh Thao Ngoc , Babl Vincent , Parker Roy 
Published: June 2022

AbstractThe presence of the m6A modification in mammalian mRNAs is proposed to promote mRNA recruitment to stress granules through the interaction with YTHDF proteins. We test this possibility by examining the accumulation of mRNAs in stress granules in both WT and ∆METTL3 mES cells, which are deficient in m6A modification. A critical observation is that all m6A modified mRNAs partition similarly into stress granules in both wild-type and m6A-deficient cells by single-molecule FISH. Moreover, multiple linear regression analysis indicates m6A modification explains only 6% of the variance in stress granule localization when controlled for length. Finally, the artificial tethering of 25 YTHDF proteins on reporter mRNAs leads to only a modest increase in mRNA partitioning to stress granules. Since most mammalian mRNAs have 4 or fewer m6A sites, and those sites are not fully modified, this argues m6A modifications are unlikely to play a significant role in recruiting mRNAs to stress granules. Taken together, these observations argue that m6A modifications play a minimal, if any, role in mRNA partitioning into stress granules.
Boosting electrocatalytic CO2–to–ethanol production via asymmetric C–C coupling
Authors: Wang Pengtang , Yang Hao , Tang Cheng , Wu Yu , Zheng Yao , Cheng Tao , Davey Kenneth , Huang Xiaoqing , Qiao Shi-Zhang 
Published: June 2022

AbstractElectroreduction of carbon dioxide (CO2) into multicarbon products provides possibility of large-scale chemicals production and is therefore of significant research and commercial interest. However, the production efficiency for ethanol (EtOH), a significant chemical feedstock, is impractically low because of limited selectivity, especially under high current operation. Here we report a new silver–modified copper–oxide catalyst (dCu2O/Ag2.3%) that exhibits a significant Faradaic efficiency of 40.8% and energy efficiency of 22.3% for boosted EtOH production. Importantly, it achieves CO2–to–ethanol conversion under high current operation with partial current density of 326.4 mA cm−2 at −0.87 V vs reversible hydrogen electrode to rank highly significantly amongst reported Cu–based catalysts. Based on in situ spectra studies we show that significantly boosted production results from tailored introduction of Ag to optimize the coordinated number and oxide state of surface Cu sites, in which the *CO adsorption is steered as both atop and bridge configuration to trigger asymmetric C–C coupling for stablization of EtOH intermediates.