bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Gendered Body in Verse: Jacob of Serugh and Romanos Melodos on the Woman with a Flow of Blood
Authors: Walsh Erin 
Published: April 2022

AbstractThis article examines the reception history of the story of the woman with a flow of blood as recounted in Mark 5:25–34, Matthew 9:20–22, and Luke 8:43–48 within the writings of two late antique poets: Jacob of Serugh (ca. 451–521 CE) and Romanos Melodos (b. ca. 485 CE). In their poetic compositions, Jacob and Romanos retell and interpret biblical stories employing narrative expansions and the attribution of imagined speech. The Syriac poet, Jacob of Serugh, wrote in the form of narrative poems, ormēmrē, while Romanos perfected the form of the Greekkontakion.Like prose homilies, these poems reached Christians from across the social spectrum, providing spiritual instruction and delighting audiences. Previous reception histories of this biblical narrative have largely overlooked late antique and early Byzantine poetry performed within the liturgical space. In addition to filling this lacuna in scholarship, this article also highlights how these understudied poems contribute to our understanding of early Christian discourses of (im)purity. Romanos emphasizes the symbolic value of the gendered body, blending the imagery of stain, impurity, and sin. In contrast, Jacob’s lexical choices and poetic style underscore the woman’s physical and emotional strife. Through speech and the description of the woman’s bodily state, both poets provide dramatic depictions of the woman’s encounter with Jesus that enrich our understanding of how late antique Christians interpreted this biblical story.
Identificación molecular de microorganismos en cultivos agrícolas, ornamentales y forestales en Costa Rica, 2009-2018. Parte 1
Authors: Blanco-Meneses Mónica 
Published: April 2022

Introducción. El Laboratorio de Técnicas Moleculares aplicadas a la Fitoprotección (LTM), Centro de Investigación en Protección de Cultivos, Universidad de Costa Rica; recibe cultivos agrícolas, ornamentales y forestales para la identificación de microorganismos por medio de técnicas moleculares. Objetivo. Identificar con técnicas moleculares hongos, oomicetes y protozoa patogénicos y no patogénicos en cultivos agrícolas, ornamentales y forestales de Costa Rica. Materiales y métodos. Entre los años 2009 y 2018, se recibieron partes de plantas (raíz, tallo, hojas, frutos) y otros materiales como agua, sustrato y suelo, de los cuales se obtuvieron 805 aislamientos para identificación de microorganimos por mediante técnicas de extracción de ADN, PCR en tiempo final y en tiempo real y secuenciación mediante marcadores moleculares. Resultados. La secuenciación permitió la identificación de un total de 154 especies de hongos, 6 oomicetos y 1 protozoa. Dentro de los hongos identificados predominaron géneros como Fusarium con catorce especies diferentes, seguidos de Colletotrichum y Aspergillus con once especies identificadas para cada uno. En los oomicetes, prevalecieron especies del género Phytophthora y dentro de los protozoa el género Plasmodiophora. Además, las referencias científicas que respaldan la presencia de los microorganismos identificados en un cultivo en particular, han sido incluidas dentro de la información. Conclusión. Fue posible identificar mediante técnicas moleculares especies de hongos, oomicetos y protozoa patogénicos y no patogénicos aislados de diferentes cultivos agrícolas, ornamentales y forestales en Costa Rica.
Çocuk kardiyoloji uzmanına kardiyak üfürüm nedeniyle gönderilen çocukların ebeveynlerindeki anksiyete düzeyinin değerlendirilmesi
Authors: BEŞİROĞLU ÇETİN Fatma , IRDEM Ahmet , KARBUZ Adem 
Published: April 2022

Amaç: Kardiyak üfürüm, çocuk kardiyoloji hekimine başvuruların önemli nedenlerindendir. Bu durum çocukların ebeveynlerinde, anksiyeteye sebep olabilmektedir. Çalışmamızda kardiyak üfürüm saptanması sonrası çocuk kardiyoloji polikliniğine yönlendirilen çocukların ebeveynlerindeki anksiyete düzeyi ve bu anksiyete ile ilişkili faktörlerin araştırılması amaçlandı.
Gereç ve Yöntemler: Çalışmamız xxx Eğitim ve Araştırma Hastanesi çocuk kardiyoloji polikliniğinde gerçekleştirildi. Çocuk kardiyoloji hekimi dışında bir hekim tarafından kardiyak üfürüm saptanıp, çocuk kardiyoloji polikliniğine yönlendirilen 0-18 yaş arası çocuklar ve çalışmaya katılmayı kabul eden ebeveynlerinden biri dahil edildi. Ebeveynlere durumluk ve sürekli kaygı envanteri 1-2 (STAI 1-2) uygulanarak anksiyete düzeyi araştırıldı.
Bulgular: Çalışmaya 137 hasta ve ebeveyni dahil edildi. Elli hastada üfürüm saptandı. Üfürüm sebepleri incelendiğinde, en sık sebep masum üfürümler idi. Çalışmaya katılan ebeveynlerin STAI-1 ölçümleri 21 ile 64 arasında değişmekte olup, ortalama 41,36±10,65 olarak saptandı. Çalışmaya katılan ebeveynlerin STAI-2 ölçümleri 23 ile 68 arasında değişmekte olup, ortalama 44,01±8,81 olarak saptandı. Ebeveynlerin STAI-1 ve STAI-2 ölçeklerinden aldıkları puanlar ile çocukların cinsiyeti, ebeveynin eğitim durumu, ebeveynin yaşı, kaçıncı çocuk olduğu, soy geçmişte kalp hastalığı veya üfürüm olması, başvuru esnasında veya üfürüm duyulduğu anda şikayet olması arasında anlamlı ilişki saptanmadı.
Sonuç: Çocuğunda üfürüm saptanan ebeveynlerin anksiyete düzeylerinin yüksek olduğu ve bu anksiyete düzeyine etki eden en önemli faktörün ebeveynin genel hayatındaki anksiyete düzeyi olduğu saptandı. Aile hekiminin ve çocuk hastalıkları uzmanının muayenesi esnasında üfürüm saptanmış çocukların çoğunluğunda çocuk kardiyoloji uzmanı tarafından üfürüm saptanmadı.
A cross-sectional study to find out the prevalence, pattern, risk factors, comorbidities and severity of vascular depression in patients attending psychiatric outpatient department in a tertiary care centre
Authors: Nigam Sandeep , Shukla Madhukar Prasad , Bhushan Samhita 
Published: April 2022

Background: Depression was declared as the second major cause of disability adjusted life years (DALY) in 2020 and the economic burden experienced by those with depression is next to coronary artery disease. Vascular depression has late age at onset 60 years or older, nonpsychotic subtype, with no family history of mental disorders, presenting with loss of pleasure and functional disability. Depression is accompanied by cerebrovascular lesions as determined by MRI and not accompanied by neurological signs. This has a spiral correlation with various comorbidities leading to diagnostic enigma at one hand and worsened prognosis on the other. This emphasized the early diagnosis and treatment to improve the quality of life.Methods: Patients with age more than 60 years, of either sex, with a mini GDS score ≥5, having the first episode of depression and who gave consent were included.Results: Hypertension thus emerged as a significant risk factor and was positively associated with increased severity of depression. Conclusions: Subclinical cognitive impairment and mild cognitive impairment (MCI) may precede years before the onset of vascular depression. Prompt detection and management of these entities and associated risk factors could prevent or postpone impending vascular depression.
Radiomics-based distinction of small (≤2cm) HCC and precancerous lesion based on precontrast MRI
Authors: Gao XiaoNing , Luo JiaWen , Guo Kun , Xiang Yue , Liu Hao , Ding Jia 
Published: April 2022

Abstract
Background: The pre-HCC describe the precancerous condition of HCC, which include regenerative nodule (RN), low-grade dysplastic nodule (LGDN) and high-grade dysplastic nodule (HGDN) [1].Purpose: To assess the feasibility of radiomics based on precontrast MRI for the distinguish of small hepatocellular carcinoma (S-HCC) (≤2cm) and pre-hepatocellular carcinoma (pre-HCC). Method: We retrospectively analyzed 146 nodules with pathological confirmed from 78 patients. Each nodule was segment on precontrast MRI sequence (T1WI and fat-suppression T2WI (FS-T2WI) ), retrospectively. 1223 radiomics features were extracted and the optimal features from T1WI, FS-T2WI and T1WI+FS-T2WI were selected by the least absolute shrinkage and selection operator (LASSO). We used the logistic regression classifier to establish the radiomics model. Result: We applied logistic regression classifier to identify S-HCC and pre-HCC on the basis of valuable radiomics features extracted from T1WI, FS-T2WI, T1WI+FS-T2WI, respectively. The AUC, sensitivity and specificity of the training group and test group based on T1WI were 0.879 (95% CI 0.797 -0.962), 78.9% and 83.1% and 0.796 (95% CI 0.619-0.973), 66.7% and 83.3%, respectively. The AUC, sensitivity and specificity of the training group and test group based on FS-T2WI were 0.911 (95% CI 0.839-0.983), 94.7% , 83.1% and 0.907 (95% CI 0.779-1), 83.3%, 88.9%, respectively. The AUC, sensitivity and specificity of the training group and test group based on T1WI+FS-T2WI were 0.918 (95% CI 0.844-0.991), 84.2% , 87.3% and 0.870 (95% CI 0.728-1), 84.2%, 87.3%, respectively. Conclusion: This study suggested that radiomics model may serve as an adjunct and noninvasive tool to classify S-HCC and pre-HCC based on precontrast MRI.
Artificial Intelligence with CBC based Morphometric Parameters aimed toward effective diagnostic practices for Dysplasia associated Hematological Malignancies
Authors: Haider Zeeshan , Ujjan Ikram Uddin , Khan Najeed Ahmed , Farooq Muhammad Umer , Nazir Waseemullah , Urrechaga Eloisa , Khanani Muhammad Rafiq 
Published: April 2022

Abstract
Background: The diagnosis and classification of dysplasia associated hematological neoplasms is dominated by morphology. Current round of study made use of potential ‘fingerprints’ among routinely generated diagnostic data particularly morphological and immature fraction-related (morphometric) parameters produced during routine complete blood count (CBC) testing in hemat-oncology department through artificial intelligence predictive modeling.Methods: Along conventional statistics, neural network models were trained on anonymized demographical, clinical and diagnostic data of total 1624 individuals with common hematological neoplasms. In addition, validation conducted on independent dataset. The frameworks were trained to differentiate hematological malignancies cases with various sub-entities of Dysplasia against Non-dysplastic group as a control cohort.Results: Our predictive model attained greater precisions; percent incorrect prediction were remained 10.3 and 4.6 for training and testing phases, respectively along with a 95.4% negative predictive value (NPV). Moreover, higher accuracy (93.1%) was obtained during prospective validation in challenge of independent dataset. Model’s performance related metrics: the gain and lift chart, predictive-pseudo probability chart, and receiver operative curve (ROC) curve were noted as persuasive. Considering the sensitivity and specificity, area under the curve (AUC) values were also noted quite convincing; 0.954 for Non-dysplasia group while 0.994 for acute myeloid leukemia with dysplasia (AML-Dys) followed by 0.992, 0.988, 0.986, 0.984, 0.973, and 0.962 for chronic myelo-monocytic leukemia (CMML), refractory anemia with excess blast-I (RAEB-I), refractory anemia with excess blast-II (RAEB-II), refractory anemia with multi-lineage dysplasia (RCMD), Hypoplastic myelodysplastic syndrome (H-MDS), and refractory anemia with uni-lineage dysplasia (RCUD) respectively.Conclusion: The negative predictive efficiency of our framework advocates its utility as a screening tool for the rapid expulsion of Dysplasia associated hematological neoplasms in hemat-oncology sections, aiding prompt care decisions.
CLPX regulates mitochondrial fatty acid β-oxidation by modulating protein complex formation in liver cells
Authors: Furuyama Kazumichi , Suzuki Ko , Kubota Yoshiko , Kaneko Kiriko , Kamata Costantine 
Published: April 2022

Abstract
Mitochondrial fatty acid oxidation (β-oxidation) is an essential metabolic process for energy production in eukaryotic cells, but the regulatory mechanisms of this pathway are largely unknown. In the present study, we found that several enzymes involved in β-oxidation are associated with CLPX, the AAA + unfoldase that is a component of the mitochondrial matrix protease ClpXP. Deletion of the CLPX gene increased β-oxidation activity in human hepatic cells but did not change the protein levels of enzymes involved in β-oxidation. Moreover, glucagon treatment resulted in decreased CLPX levels and increased β-oxidation activity in these cells, while the expression levels of enzymes involved in β-oxidation were not altered. Coimmunoprecipitation experiments revealed that glucagon treatment induced the dissociation of several β-oxidation-related enzymes from CLPX, suggesting that CLPX regulates β-oxidation by modulating the protein complex formation of enzymes catalyzing β-oxidation.
Femoral head osteonecrosis post-COVID-19 infection, a prophecy coming true. A report of seven hips.
Authors: Mahran Mohamed A. , Hassan Ahmed Abdelazim A. , Moustafa Mohamed MA , Bakr Hatem , Abdelaal Ahmed M. , Khalifa Ahmed A. 
Published: April 2022

Abstract
Background: COVID-19 is relatively a new condition, the long-term effects of which have not been thoroughly studied yet. Musculoskeletal complications following COVID-19 infection or because of its medications used had been reported in the literature. Here, we report on seven hips in four patients who presented with osteonecrosis of the femoral head (ONFH) after having COVID-19 infection and their treatment regimen included glucocorticoid. Cases presentation: Four patients presented to us complaining of hip pain (bilateral in three patients and unilateral in one), all reported being diagnosed as having COVID-19 infection, and their line of management included corticosteroids intake for various durations. The diagnosis was confirmed by plain hip radiographs and magnetic resonance imaging. The disease was in the early stages in all patients without femoral head collapse. Thus, all hips were treated by core decompression.Conclusion: ONFH is a real concern in patients who had COVID-19 infection, especially when corticosteroids were administered as part of their management. A follow-up and screening strategy should be established for patients who had COVID-19 infection to detect early development of hip osteonecrosis.
Perceptions and attitudes of black men in a rural district of South Africa towards depression and its treatment
Authors: Masemola Hlabje Carel , Moodley Saiendhra Vasudevan , Shirinde Joyce 
Published: April 2022

Abstract
Background: Depression is a major contributor to the overall global burden of disease impacting social life, family life, and occupational functioning if left untreated. Despite its high prevalence and morbidity, the evidence suggests men are hesitant to seek help with a large percentage remaining undiagnosed. This study aimed to determine the attitudes and perceptions related to depression and its treatment among black men in a rural district of South Africa. Methods: The design used was exploratory descriptive qualitative design. Participants were selected by purposive sampling technique. Individual semi-structured interviews were conducted which were audio-recorded and transcribed verbatim. The data were subsequently analysed thematically to develop themes and subthemes.Results: Participants described depression as a psychological problem associated with lack of sleep, loneliness, feeling unwanted, increased stress, deep sadness, weight loss, forgetfulness, crying over small things, and lack of concentration. Collectively, the interviews with participants exposed a limited understanding of the causes of depression. A large proportion (n=13) of participants reported not having knowledge of available services in their area for people who seek treatment for depression. Barriers to help-seeking behaviours were fear of social stigma, fear of expressing their feelings, gender norms and stereotypes, and lack of trust in others.Conclusions: Interventions such as support groups and mental health awareness programs to counteract personal perceptions may help to improve and expand the effectiveness of depression treatment. The results highlight the future need to raise awareness of depression symptoms and expand outreach health programs.
Finding the best approach for the transportation sector to synergistically reduce CO2 and air pollutants emissions
Authors: Wang Yuan , Ping Liying , Lee Lien-Chieh , Zhang Hongyu , Peng Binbin , Pan Zhou , Yang Chenbo 
Published: April 2022

Abstract
The transportation sector has a significant impact on the synergistic reduction of CO2 and pollutants. Using a structural path decomposition, we reveals the direct and embodied CO2 and NOx emissions from the transportation sector triggered by key supply chain pathways. Meanwhile, the emission abatement potential and economic costs of 33 vehicle specific abatement technology options are analyzed based on the input-output analysis for life cycle assessment. The results show that most of the vehicle technology options can reduce CO2 and NOx emissions while saving economic costs. Among these technologies, both the pure electric technology for passenger cars and the parallel hybrid technology for heavy-duty trucks have high abatement potential. Compared to costly pure electrification technologies for passenger cars, parallel hybrid technologies for heavy-duty trucks offer the highest economic benefits as well as a better driving mileage. Therefore, hybrid heavy-duty trucks will be a more comprehensive solution in the near future.
Cerebrospinal fluid circulating tumor DNA depicts profiling of brain metastasis in NSCLC
Authors: Zhang Longbo , Wu Jun , Liu Zhiqiang , Huang Tianxiang , Wang Ying , Song Mengmeng , Song Tao , Zhang Xiaobing , Li Xi , Long Gretchen 
Published: April 2022

Abstract
Brain metastasis (BM) genetically diverges from the primary tumor in non-small-cell lung cancer (NSCLC). Hence, accurately capturing clinically relevant alterations is pivotal for the delivery of targeted therapies. Circulating tumor DNA (ctDNA) sequencing has emerged as a promising liquid biopsy in the biomarker-based clinical management of recurrent and extracranial metastatic NSCLC. However, absence of simultaneous sequencing data from brain metastatic sites prevents the definitive evaluation of the efficacy of ctDNA representing genetic profiles in BM. Here, we performed parallel genomic comparisons between matched BM and primary tumor DNA, plasma ctDNA, and cerebrospinal fluid (CSF) ctDNA. The results indicated that CSF ctDNA had a greater ability than plasma ctDNA in comprehensively representing the mutational landscape of BM, with CSF ctDNA detecting all BM mutations in 83.33% of patients while plasma ctDNA was only 27.78%. Mutant allele frequency (MAF) in CSF ctDNA was highly correlated with the tumor size of BM (r = 0.95), and the mean MAF in CSF ctDNA was more abundant than that in plasma ctDNA (38.05% vs. 4.57%). MAF and tumor mutational burden (TMB) in CSF ctDNA were strongly associated with those in BM (r = 0.96 and 0.97, respectively). Of note, CSF ctDNA had significantly higher concordance with BM than plasma ctDNA (99.33% vs. 67.44%), facilitating the identification of clinically relevant mutations. Moreover, we found that plasma ctDNA has stronger profiling performance with a concordance of 93.01% in multiple brain metastases, equivalent to CSF ctDNA. Collectively, our study indicates that CSF ctDNA is superior to plasma ctDNA in accurately represent the profiling of single BM, plasma ctDNA could be an alternative liquid biopsy material to be applied in multiple brain metastatic NSCLC.
A density functional theory study of adsorption and dissociation of H2 molecule on small PdnAgm (n + m ≤ 4) metal clusters
Authors: Al-Odail Faisal , Mazher Javed 
Published: April 2022

Abstract
The adsorption and dissociation of hydrogen molecule on small PdnAgm (n + m ≤ 4) clusters is studied employing density functional theory (DFT) calculations. The lowest energy structures of the PdnAgm clusters are initially presented. Based on the obtained structures, various geometries of H2 adorption and dissociation with these clusters are examined. The cluster size and composition of the PdnAgm clusters are found to control the nature of the adsorption process. The results suggest that molecular adsorption is more favourable on the Pd atom and mixed clusters, while hydrogen dissociation is more favourable on the Pdn (n = 2–4) clusters. The Pd dimer and trimer are found to be the most reactive clusters for hydrogen adsorption, while single Ag atom is the least reactive one. The natural bond orbital (NBO) population analysis indicates that hydrogen atoms tend to draw electrons from the metal clusters in the dissociative form and donate electrons to the metal clusters in the molecular adsorption form. The density of states (DOS) of the PdnAgm trimers are also presented and discussed.
Assessment of social vulnerability to groundwater pollution using K-means cluster analysis.
Authors: Uzcategui-Salazar Marisela , Lillo Javier 
Published: April 2022

Abstract
It is possible to assess the harm that society suffers from an anthropogenic event based on the impact of groundwater pollution on society. Indexing methodologies are commonly applied to assess the social vulnerability of aquifers. However, they assign weighting and rating values for the different factors involved, make them very subjective. This research proposes to assess the social vulnerability to groundwater pollution by considering three factors: the uses of groundwater resources, the exposed population, and the socio-economic losses. In order to eliminate the subjectivity of indexing methodologies, a K-means cluster analysis was used to assess the social vulnerability. Using this method, a social vulnerability map can be produced with greater objectivity. The proposed methodology was applied to an aquifer located in central Spain, an area with significant agricultural development. Low population density and unproductive zones result in low social vulnerability in most of the area. Nevertheless, high social vulnerability is observed in the southern regions due to agricultural development which leads to higher socio-economic variables and demand for groundwater resources for agricultural activities. Similarly, high social vulnerability is observed in the northeast, mainly influenced by groundwater use and exposed population. These results show that social vulnerability in most of the study area is not very significant for assessing the risk of groundwater contamination, because the damage to the social, environmental or economic sector is low. However, in the south and northeast in the study area, pesticides and fertilisers should be used with caution, as they significantly increase the risk of groundwater contamination and thus the impact on society. The K-means clustering method proved to be an objective and effective option for assessing social vulnerability to groundwater pollution in aquifers.