bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of physical activity on the academic performance of undergraduate physiotherapy students at Sindh Institute of Physical Medicine and Rehabilitation.
Authors: Awan Tabeer Tanwir , Awan Tamseel Tanwir , Awan Imtesaal Tanwir , Khalid Farah 
Published: April 2022

Abstract
Background:
Despite the health and wellness outlook of physical activity, the number of studies that associate physical activity, and academic performance has been increased. Modern research has described the involvement of physical activity on academic performance of students at primary, secondary, and university levels which may be influenced by upgrading in attention, administrative functions, and work memory because of increased blood circulation and neurogenesis by performing physical activity. This study aimed to evaluate the association of physical activity on the academic performance of undergraduate physiotherapy students at Sindh Institute of Physical Medicine and Rehabilitation.
Methods:
This was an observational, cross-sectional study conducted in June 2021 at Sindh Institute of Physical and Medicine Rehabilitation. Undergraduate DPT students from the second year till the fifth year enrolled in Sindh Institute of Physical Medicine and Rehabilitation were taken in the study. Data collection was done by using non-probability purposive sampling for the sample size of 365 DPT students. Α self-administered web-based survey questionnaire was used to collect data. Data were analysed on SPSS program Version 20. By using descriptive statistic age, gender, and study year was analysed. The mean difference of the scores derived from IPAQ with gender and study year were assessed through parametric tests. The relationship of physical activity with academic performance was investigated through the non-parametric test of Chi-square.
Results:
The mean difference of IPAQ scores did not show much difference between the two genders to have a better physical activity level than the other (p-value: 0.772). There was no significant difference between study years with total physical activity scores (p-value: 0.158). According to cross-tabulation, 50% of students who had a GPA around the 2.1-3.0 range and 51.70% who had a GPA around the 3.1-4.0 range were classified in low activity level. Therefore, we conclude that a non-significant association between physical activity and academic performance was found among undergraduate physiotherapy students in SIPMR.
Conclusion:
The deduction to our research is that there was no link between physical activity with academic performance. Along with that, there was no evidence found in the current study about either gender being more physically active than others. Students from all the years in SIPMR had the same level of activity level and there was no significant difference found.
New evidence of the emergence of East Asian monsoon in the early Palaeogene: A palynology perspective from central China
Authors: Zhang Qianqian , Su Lifei , Sun Yankun , Zhang Shaoliang , Smith Thierry , Li Chengsen 
Published: April 2022

Abstract
Earlier palaeoenvironmental reconstructions implied that East Asia climates were dominated by a zonal climate pattern during the Eocene, with an almost latitudinal arid/semiarid band around ~ 30° N paleolatitudes. However, this long-standing model has recently been challenged by growing multidisciplinary evidence. Some previous studies indicated that the middle part of what is now China had was characterized by climatic fluctuations between humid and relatively dry during the Early Eocene, akin to present East Asian monsoon regimes (EAM). Therefore, whether the EAM existed in the Early Eocene has been under much attention and debate in the scientific community. Using palynological assemblages in the Tantou Basin, central China, we quantitatively reconstructed climate changes from the Late Palaeocene to the Early Eocene to better understand climate change in East Asia. The palynological assemblages revealed that the coniferous and broad-leaved mixed forest in this area received no less than 800 mm of annual precipitation and experienced a climate change process from warm and wet to relitively cool and dry. According to palaeoclimate change curves, sudden climate change occurred in the Early Eocene, with mean annual temperature and MAP decreasing by 5.1 ℃ and 214.8 mm, respectively to become very similar to the present climate which controlled by monsoon climate. So, we inferred that this significant climate change during the Early Eocene may signal the emergence of the EAM in East Asia.
Central positional vertigo as first initial multiple sclerosis symptom: a case report with systematic review.
Authors: Meshref Mostafa , Shaheen Ahmed , Elmatboly Abdelmagid M. , Abdella Walid Shaban , Amro Yara , Khairat Shiamaa M. , Swed Sarya 
Published: April 2022

Abstract
Multiple sclerosis is a disease that affects the central nervous system, resulting in a variety of symptoms such as vision, physical activity and stability. Central positional vertigo as an initial multiple sclerosis symptoms is a rare case in the literature.
Systematic identification of cell fate regulatory programs using a single-cell atlas of mouse development
Authors: Fei Lijiang , Chen Haide , Ma Lifeng , E Weigao , Wang Renying , Fang Xing , Zhou Ziming , Sun Huiyu , Wang Jingjing , Jiang Mengmeng , Wang Xinru , Yu Chengxuan , Mei Yuqing , Jia Danmei , Zhang Tingyue , Han Xiaoping , Guo Guoji 
Published: April 2022

Abstract
Waddington’s epigenetic landscape is an abstract metaphor frequently used to explain cell fate decisions. Recent advances in single-cell genomics are altering our understanding of the Waddington landscape. Yet, the molecular regulations behind remain poorly understood. We construct a dynamic cell landscape of mouse lineage differentiation at the single-cell level and thereby reveal both lineage-common and lineage-specific regulatoryprograms during cell type maturation. We verify lineage-common regulatory programs that are universal during the development of invertebrates and vertebrates. In particular, we identify Xbp1 as an evolutionarily conserved regulator of cell fate determinations across different species. We demonstrate that Xbp1 transcriptional regulation is important for the stabilization of the genetic network for a wide range of cell types. Our results offer genetic and molecular insights into the gene regulatory programs systematically and provide resources to advance the understanding of the cell fate decisions.
Adsorption of levofloxacin on natural zeolite: effects of ammonia nitrogen and humic acid
Authors: Chi Xiaoying , Zeng Lixuan , Du Yuejin , Huang Jiaquan , Kang Yuan , Luo Jiwen , Zhang Qiuyun 
Published: April 2022

Abstract
The persistence of antibiotics in sewage treatment plants in recent years has become a serious problem. Meanwhile, humic acid and ammonia nitrogen are widely distributed in natural reservoirs and might influence the sorption, migration and transformation of antibiotics. In this study, natural zeolite (NZ) was evaluated as an adsorbent for the removal of levofloxacin (LEV). The physical and chemical properties of NZ before and after adsorption were characterized by various analytical techniques to develop the mechanism. The effects of ammonia nitrogen and humic acid (HA) on the interfacial behavior of LEV on NZ were explored. Comparative experiments revealed that LEV adsorption on NZ involved electrostatic interactions and ion exchange, and the adsorption processes were well fitted by the Langmuir isotherm model and pseudosecond-order kinetic model. The maximum experimental adsorption capacity of LEV was 22.17 mg·g−1 at pH 6.5. The presence of ammonia nitrogen and HA significantly suppressed the adsorption of LEV due to competitive adsorption, and the adsorption capacity decreased 58 and 46%, respectively. It is obvious that low concentrations of ammonia nitrogen and HA are conducive to improving the treatment effect of sewage. This study demonstrates that NZ is a promising and efficient material for LEV adsorption.
Identification of Immune Infiltration and Prognostic Biomarkers in Small
Cell Lung Cancer Based on Bioinformatic Methods from 3 Studies
Authors: Yu Changhua , Cao Jiaoyan 
Published: April 2022

Aims:
This study aimed to investigate the correlation between gene expression and immune
cell infiltration and the overall survival rate in tumor tissues, which may contribute to the
therapy and prognosis of small cell lung cancer (SCLC) patients.

Background:
SCLC is the most aggressive type of lung neoplasm. There is no proper marker for
the treatment and prediction of prognosis in SCLC.

Objectives:
Three gene expression profiles of SCLC patients were obtained from the Gene Expression
Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified between
normal lung samples and SCLC lung samples.

Methods:
Functional enrichment analysis of all DEGs was performed to explore the linkage among
DEGs, the tumor immune microenvironment, and SCLC tumorigenesis. The common genes among
the 3 groups in the Venn diagram and hub genes in protein-protein interaction (PPI) networks were
considered potential key genes in SCLC patients. The TIMER (tumor immune estimation resource)
database calculation and Kaplan–Meier survival curves were used to investigate the association between
potential key genes and immune infiltrate prognosis of SCLC patients.

Results:
A total of 750 (top 250 from each study) differentially expressed genes (DEGs) were
identified. CLDN18 and BRIP1 were significantly related to immune infiltration in the tumor microenvironment.
SHCBP1 and KIF23 were related mostly to prognosis in SCLC patients.

Conclusion:
The present study may provide some potential biomarkers for the therapy and prognosis
of SCLC.
Synthesis, Antimicrobial Activity, and Molecular Modeling Studies of
Some Benzoxazole Derivatives
Authors: Muhammed Muhammed Tilahun , Kuyucuklu Gulcan , Kaynak-Onurdag Fatma , Aki-Yalcin Esin 
Published: April 2022

Background:
The need to develop novel antimicrobial agents is apparent as infectious diseases
are increasing and resistance is rapidly developing against the drugs used in the treatment.

Objective:
This study aimed at the synthesis, antimicrobial susceptibility testing, and computational elucidation
of the mechanism of action of benzoxazole derivatives. It also aimed to compare the results obtained
in this study with the previous studies by our group. This would pave the way for designing novel
molecules with better antimicrobial activity. The other goal was pharmacophore analysis and in silico
ADMET analysis of them.

Methods:
In this study, synthesis, antimicrobial susceptibility testing, molecular docking, pharmacophore
analysis, and ADMET prediction were carried out.

Results:
The antimicrobial activity studies demonstrated that the synthesized compounds were active
against standard strains and clinical isolates at high concentrations. Then, the antimicrobial testing results
were compared to similar benzoxazoles tested by our group previously. Benzoxazole derivatives without
a methylene bridge between oxazole and phenyl ring were found to be more active than those with the
methylene bridge. This was also confirmed by molecular modeling undertaken in this study. The computational
results indicated that the antibacterial activity could be achieved by DNA gyrase inhibition.
Pharmacophore analysis showed that hydrogen bond acceptor (HBA), hydrogen bond donor (HBD), and
hydrophobicity features would contribute to the inhibition. In addition, in silico ADMET property investigation
of the compounds exhibited that they had the desired pharmacokinetics.

Conclusion:
Although antibacterial activity by inhibiting DNA gyrase is selective, the synthesized compounds
were active at much higher concentrations than the standards. Therefore, in prospective antimicrobial
studies, it is better to focus on benzoxazole derivatives without the methylene bridge. Since the
compounds had suitable in silico ADMET properties, screening them against the other pharmacologic
activities should be carried out. It is recommended to support the molecular modeling results with in vitro
or in vivo studies.
Evaluation of Prescribing Pattern, Therapeutic Adherence and Occurrence
of Adverse Drug Reactions in Patients with Type 2 Diabetes Mellitus
Authors: Akhtar Md. Sayeed , Sharma Manju , Sani Sanusi , Kapur Prem , Sharma Gunjan , Tabassum Fauzia , Khan Mohd Faiyaz 
Published: April 2022

Background:
Persistent hyperglycemia in diabetes mellitus (DM) is considered the leading
cause of morbidity and mortality associated with both microvascular and macrovascular complications,
having a greater economic impact. This study aimed to assess the impact of socioeconomic status,
prescribing patterns, and patient compliance in type 2 diabetes mellitus patients.

Method:
This study was carried out at the Department of Medicine and Diabetic Clinic of Hakeem
Abdul Hameed (HAH) Centenary Hospital at Hamdard University, New Delhi, India. We conducted a
prospective observational study on prescribing patterns and monitoring adverse drug reactions (ADRs)
in patients with type 2 DM (T2DM) under standard care. We enrolled 150 confirmed cases, and data
was obtained from pre-validated questionnaires and then coded and analyzed to observe the association
between variables.

Results:
The glycosylated haemoglobin level in 56% of the cases was between 6.4 to 8.0, and cardiovascular
complications were observed as the major comorbidities. 45.33 % of the cases were on mono
drug therapy, and metformin (23. 52 %) was the drug of choice, followed by glimepiride (23.52 %).
Among the dual drug therapies, sitagliptin with metformin and triple-drug therapy, glimepiride concurrent
with metformin and voglibose was the most preferred drug in the treatment of T2DM.
Sitagliptin was observed to be a major patient burden (46.213 USD). In only 7.33 % of the cases, we
observed definite ADR in T2DM patients. Underprivileged awareness, mainly due to low literacy, was
a major concern in the development of new cases of T2DM.

Conclusion:
We observed better patient compliance; however, a disease awareness program must be implemented.
The use of oral hypoglycaemic drugs is still dominant in clinical practice and cardiovascular
disorders as comorbidities emerge as a greater challenge in terms of patient outcome and cost burden.
A duális képzés bevezetésének nemzetközi tapasztalatai néhány ország példáján keresztül
Authors: Toth Katalin 
Published: April 2022

Magyarországon 2015-ben bevezetésre került a duális képzés. A duális képzés a munkaerőpiac igényeire adott válasz, mely bevezetése óta egyre népszerűbb. A duális képzés nemzetközi szinten is egyre jelentősebb szerepet tölt be a felsőoktatásban, segítve az oktatás, az átadott tudásanyag modernizálását és előmozdítva a vállalatok és az egyetemek kapcsolatának erősödését. A cikk célja, hogy bemutassa a duális képzés rendszerét és az eltelt időszakban összegyűjtött nemzetközi tapasztalatokat. a témában fellelhető szakirodalomra támaszkodva.
Detecting Anomalies in Daily Activity Routines of Older Persons in Single Resident Smart Homes: Proof-of-Concept Study
Authors: Shahid Zahraa Khais , Saguna Saguna , Åhlund Christer 
Published: April 2022

Background
One of the main challenges of health monitoring systems is the support of older persons in living independently in their homes and with relatives. Smart homes equipped with internet of things devices can allow older persons to live longer in their homes. Previous surveys used to identify sensor-based data sets in human activity recognition systems have been limited by the use of public data set characteristics, data collected in a controlled environment, and a limited number of older participants.

Objective
The objective of our study is to build a model that can learn the daily routines of older persons, detect deviations in daily living behavior, and notify these anomalies in near real-time to relatives.

Methods
We extracted features from large-scale sensor data by calculating the time duration and frequency of visits. Anomalies were detected using a parametric statistical approach, unusually short or long durations being detected by estimating the mean (μ) and standard deviation (σ) over hourly time windows (80 to 355 days) for different apartments. The confidence level is at least 75% of the tested values within two (σ) from the mean. An anomaly was triggered where the actual duration was outside the limits of 2 standard deviations (μ−2σ, μ+2σ), activity nonoccurrence, or absence of activity.

Results
The patterns detected from sensor data matched the routines self-reported by users. Our system observed approximately 1000 meals and bathroom activities and notifications sent to 9 apartments between July and August 2020. A service evaluation of received notifications showed a positive user experience, an average score of 4 being received on a 1 to 5 Likert-like scale. One was poor, two fair, three good, four very good, and five excellent. Our approach considered more than 75% of the observed meal activities were normal. This figure, in reality, was 93%, normal observed meal activities of all participants falling within 2 standard deviations of the mean.

Conclusions
In this research, we developed, implemented, and evaluated a real-time monitoring system of older participants in an uncontrolled environment, with off-the-shelf sensors and internet of things devices being used in the homes of older persons. We also developed an SMS-based notification service and conducted user evaluations. This service acts as an extension of the health/social care services operated by the municipality of Skellefteå provided to older persons and relatives.
Helping Children to Participate in Human Papillomavirus–Related Discussions: Mixed Methods Study of Multimedia Messages
Authors: Occa Aurora , Stahl Hayley M , Julien-Bell Sarah 
Published: April 2022

Background
Human papillomavirus (HPV) can cause several types of cancers and genital warts. A vaccine is available to prevent HPV infections, and several efforts have been made to increase HPV education and, eventually, vaccination. Although previous studies have focused on the development of messages to educate children about HPV and the existence of the HPV vaccine, limited research is available on how to help children better communicate with their parents and health care professionals about the HPV vaccination. In addition, limited research is available on the target audience of this study (Italian children).

Objective
This manuscript describes a study assessing the feasibility of using an evidence-based animated video and a web-based game to help children (aged 11-12 years) participate in discussions about their health—in particular when such conversations center around the HPV vaccination—and improve several HPV-related outcomes. The study also compares the effects of these 2 educational multimedia materials on children’s knowledge and perceptions of HPV prevention.

Methods
A mixed methods approach consisting of focus group discussions and an experiment with children (N=35) was used to understand children’s experiences with, and perceptions of, the animated video and the game and to measure possible improvements resulting from their interaction with these materials.

Results
Both the animated video and a web-based game increased children’s knowledge and positive perceptions about HPV and HPV vaccination. Any single message was not more effective than the others. The children discussed aspects of the features and characters they liked and those that need improvements.

Conclusions
This study shows that both materials were effective for improving children’s education about the HPV vaccine and for helping them to feel more comfortable and willing to communicate with their parents and health care professionals about their health. Several elements emerged that will allow further improvements in the design and development of the messages used in this study as well as the creation of future campaigns.
Development of a Peer Support Mobile App and Web-Based Lesson for Adolescent Mental Health (Mind Your Mate): User-Centered Design Approach
Authors: Birrell Louise , Furneaux-Bate Ainsley , Debenham Jennifer , Spallek Sophia , Newton Nicola , Chapman Catherine 
Published: April 2022

Background
Digital technologies and mobile interventions are possible tools for prevention initiatives to target the substantial social and economic impacts that anxiety, mood, and substance use disorders have on young people.

Objective
This paper described the design and development of the Mind your Mate program, a smartphone app and introductory classroom lesson enhancing peer support around the topics of anxiety, depression, and substance use for adolescents.

Methods
The development of Mind your Mate was an iterative process conducted in collaboration with adolescents (n=23), experts, school staff, and software developers. The development process consisted of 3 stages: scoping; end-user consultations, including a web-based survey and 2 focus groups with 23 adolescents (mean age 15.9, SD 0.6 years); and app development and beta-testing.

Results
This process resulted in a smartphone peer support app and introductory classroom lesson aimed at empowering adolescents to access evidence-based information and tools to better support peers regarding mental health and substance use–related issues. The program contains links to external support services and encourages adolescents to reach out for help if they are concerned about themselves or a friend.

Conclusions
The Mind your Mate program was developed in collaboration with a number of key stakeholders in youth mental health, including adolescents. The resulting program has the potential to be taken to scale to aid prevention efforts for youth mental health and substance use. The next step is to conduct a randomized controlled trial testing the feasibility, acceptability, and efficacy of the program.
PENGARUH PRODUK DOMESTIK BRUTO DAN BI RATE TERHADAP RETURN ON ASSETS INDUSTRI ROKOK PERIODE 2008 – 2018
Authors: Abrianto Muhammad Kareza , Prameswari Hanifah Almira , Harits Abdul 
Published: April 2022

Penelitian ini bertujuan untuk mengetahui pengaruh produk domestik bruto, dan suku bunga acuan (BI Rate) terhadap ROA industri rokok. Penelitian yang digunakan merupakan jenis penelitian asosiatif dengan pendekatan kuantitatif. Data yang digunakan merupakan data sekunder berbentuk time series tahun 2008 – 2018 dengan metode purposive sampling sebanyak 20 sampel. Model regresi linear berganda digunakan sebagai Teknik analisis dalam penelitian ini. Hasil penelitian ini menunjukkan bahwa secara simultan (Uji F) dan parsial (Uji T) produk domestik bruto (PDB) dan suku bunga acuan (BI Rate) tidak berpengaruh positif dan signifikan terhadap ROA sub-sektor industri rokok. Kata Kunci: Produk Domestik Bruto, Suku Bunga Acuan (BI Rate), ROA,
Mortality from COVID-19 in patients with tuberculosis: systematic review and meta-analysis
Authors: Lebedeva I. B. , Shmakova M. A. , Drozdova O. M. , Brusina E. B. 
Published: April 2022

Aim. To perform a systematic analysis of COVID-19 adverse outcomes in patients with tuberculosis.Materials and Methods. We queried PubMed, Cochrane Library, Embase, ClinicalTrials.gov, medRxiv, bioRxiv, and Elibrary databases for studies on COVID-19-related mortality in patients with tuberculosis published from 2020 to 2022. We considered open randomised controlled trials, cohort, and case-control studies. Pseudorandomisation and interventional studies have been excluded from the analysis as well as those without a clear comparison group (i.e., patients without tuberculosis) and duplicate studies.Results. Out of 23,296 hits, 10 studies were included in our review. The risk of death in patients with COVID-19 and tuberculosis was significantly higher (odds ratio = 2.24, 95% confidence interval = 1.46 – 3.43] as compared with the patients without tuberculosis.Conclusion. Tuberculosis is associated with COVID-19-related mortality.