bluuebunny/crossref_metadata_2025_split huggingface dataset:
Familial Hypercholesterolaemia in Children and Adolescents: Current and
Future Perspectives
Authors: Bassareo Pier Paolo , Martino Francesco , Barilla Francesco , Martino Eliana , Calcaterra Giuseppe , Fanos Vassilios 
Published: September 2022

Abstract:
Familial hypercholesterolemia (FH) is a genetic disease, the underlying cause of which is represented by mutations capable of influencing the metabolism of low-density lipoproteins (LDL). The distinguishing characteristic of FH is increased LDL cholesterol blood levels since birth which trigger early development of atherosclerosis-related diseases. Diagnosis of FH is frequently either missed or made with a considerable delay. Prompt identification of the disease is pivotal in implementing early prevention measures. Safe and effective drugs have been approved for use in children and adolescents, with statins, with or without ezetimibe, representing first-line therapy. At times, however, these medications may not be sufficient to achieve the therapeutic target, particularly in homozygous FH patients. In such cases, lipoprotein apheresis, which has proved to be safe and efficient, is strongly suggested. New drugs still at the investigational stage may represent a promising and personalised therapy. The lowering of cholesterol levels in childhood hampers the formation of arterial atherosclerotic plaques, thus reducing cardiovascular events later in life. Accordingly, early detection, diagnosis, and therapy in FH subjects are priority aims.
Rodent Gingival Tissue Culture in an Aging Experimental Model: A Pilot Study
Authors: Mutiara Arrum , Sulijaya Benso , Masulili Sri Lelyati C. , Bachtiar Boy M. , Sumbayak Ines A. , Tadjoedin Fatimah Maria , Wati Permana , Kartika Devi 
Published: September 2022

Background:
Gingiva acts as a barrier to prevent further invasion of pathogens in periodontitis. The gingival structure consists of epithelial tissue and connective tissue. As the aging process continues, there are several changes in the periodontium. Previous studies have tried to investigate the complex interaction between the host immune system and bacteria by using animal models, especially rodents.

Objective:
The aim of the study was to evaluate the effectiveness of collecting gingival tissue from the palate and retromolar pad.

Materials and Methods:
The aging experimental model had two age categories of male rodents of 18 and 58 weeks. Tissue was collected from the mandible retromolar pad and palate with full-thickness excision. Tissues were transferred to a complete medium at 4°C. Gingival tissue was cultured in a 37°C culture incubator at 5% CO2. Tissue proliferation was observed on the first, third, and fifth days using the hemocytometer. The cell metabolism rate between the two age categories was checked using the MTT Assay. Two-way ANOVA was used for statistical analysis.

Results:
Gingival tissues obtained from the experimental models of two age categories were alive, and proliferation was observed. The old rodent group showed no significant result in terms of cell morphology on the first vs. third day (p>0.05), but significant results were found on the first vs. fifth day and third day vs. the fifth day (p<0.05). The young rodent group showed the most significant morphology changes between days. In both young and old categories, no significant difference was observed in the cell metabolism.

Conclusion:
Rodent gingival tissue collection from the retromolar pad and palate was found suitable for tissue culture in the aging experimental study.
Internal factors that are influencing in determining the selction of expertise programs in vocational high school
Authors: Rahdiyanta Dwi , Syauqi Khusni , Arifin Achmad 
Published: September 2022

This study aims to examine the effect of students' internal factors (information literacy, self-understanding, and attitude) on their decision to enroll in the mechanical engineering program of vocational high school. It is ex-post facto correlation research using a sample of 300 out of a total of 1,086 students. The sample was established using the proportional random sampling technique by means of the Krejcie and Morgan formula. The data were collected by means of questionnaires, observation sheets, and documents. The findings reveal that (1) There is a significant and positive correlation between the internal factors and the student's decision to enroll in the mechanical engineering program of vocational high school (VHS); and (2) All internal factors have a significant effect on both directly and indirectly on the students' preference for mechanical engineering program of vocational high school (VHS).
Impact and Perceived Value of iGeriCare e-Learning Among Dementia Care Partners and Others: Pilot Evaluation Using the IAM4all Questionnaire
Authors: Scott Andrew F , Ayers Stephanie , Pluye Pierre , Grad Roland , Sztramko Richard , Marr Sharon , Papaioannou Alexandra , Clark Sandra , Gerantonis Patricia , Levinson Anthony J 
Published: September 2022

Background
Care partners of people living with dementia may benefit from web-based education. We developed iGeriCare, an award-winning internet-based platform with 12 multimedia e-learning lessons about dementia.

Objective
Our objective was to evaluate users’ perceptions of impact.

Methods
From March 17, 2021 to May 16, 2022, data were collected upon lesson completion. We used the content-validated Information Assessment Method for all (IAM4all) for patients and the public adapted for dementia care partners. The IAM4all questionnaire assesses outcomes of web-based consumer health information. Responses were collected using SurveyMonkey, and data were analyzed using IBM SPSS Statistics (version 28).

Results
A total of 409 responses were collected, with 389 (95.1%) survey respondents completing the survey. Of 409 respondents, 179 (43.8%) identified as a family or friend care partner, 84 (20.5%) identified as an individual concerned they may have mild cognitive impairment or dementia, 380 (92.9%) identified the lesson as relevant or very relevant, and 403 (98.5%) understood the lesson well or very well. Over half of respondents felt they were motivated to learn more, they were taught something new, or they felt validated in what they do, while some felt reassured or felt that the lesson refreshed their memory. Of 409 respondents, 401 (98%) said they would use the information, in particular, to better understand something, discuss the information with someone else, do things differently, or do something.

Conclusions
Users identified iGeriCare as relevant and beneficial and said that they would use the information. To our knowledge, this is the first time the IAM4all questionnaire has been used to assess patient and caregiver feedback on internet-based dementia education resources. A randomized controlled trial to study feasibility and impact on caregiver knowledge, self-efficacy, and burden is in progress.
El derecho al trabajo como límite frente al despido sin causa en Argentina
Authors: Suárez María Florencia 
Published: September 2022

Comprender el significado, contenido y alcance con que el derecho al trabajo es reconocido legalmente a nivel internacional. Analizar su evolución en nuestro país hasta lograr su inclusión constitucional definitiva en 1994 y explorar las posibilidades del derecho al trabajo para actuar como límite protector frente al despido arbitrario. Iniciamos el desarrollo de este artículo relevando los principales instrumentos que refieren al derecho al trabajo en forma directa o indirecta. Luego describimos su proceso de recepción constitucional. Por último, a partir de preguntar si es posible un derecho al trabajo sin estabilidad, si su recepción constitucional es suficiente para tal fin y cuál sería la mejor forma de garantizar el derecho al trabajo apelamos al derecho comparado y a la teoría garantista de Ferrajoli (2001) en un ineludible test de compatibilidad entre un sistema de estabilidad relativa impropia[1] como el nuestro y las posibilidades concretas de garantizar su respeto. Una revisión general de los instrumentos internacionales nos permitió tener una noción integral del sistema de derecho internacional y del marco protector del trabajo en el mundo. También descubrimos que su recepción constitucional no estuvo exenta de contradicciones ni retrocesos y que se edificó en diversas etapas representadas por distintos momentos históricos, modelos de Estado y reformas constitucionales produciendo importantes consecuencias.
Finalmente, concluimos en que un sistema de estabilidad relativa impropia como el nuestro resulta incompatible con la posibilidad de garantizar el respeto del derecho al trabajo.

[1] En 1974 con la sanción de la Ley de Contrato de Trabajo (LCT) se consolidó para la generalidad de los trabajadores privados, un sistema de estabilidad impropia por medio del cual se le impone al empleador que despida sin causa a un trabajador vinculado por un contrato de tiempo indeterminado, una indemnización tarifada basada en la antigüedad en el empleo y en el salario del dependiente.
Um trabalho com tecnologias digitais em cursos de formação de professores de Matemática: possibilidades para o pensar
Authors: Pavanelo Elisangela 
Published: September 2022

Este artigo tem como objetivo discutir como um trabalho com Tecnologias Digitais (TD) que apresenta uma atividade de investigação pode criar possibilidades para o pensar nas aulas de Matemática. Apresentamos esse ‘pensar’ a partir da teoria de Heidegger. O trabalho traz a discussão para os cursos de formação de professores, onde propõe que a abertura para a investigação, para a discussão e a criação pode se dar em cada uma de suas disciplinas, não só nas que se relacionam diretamente com a área pedagógica. O trabalho, que se desenvolve a partir de uma pesquisa qualitativa com enfoque fenomenológico, propõe uma atividade, com foco no Teorema Fundamental do Cálculo, um tema importante para o Cálculo Diferencial e Integral. A atividade foi desenvolvida com alunos de um curso de Licenciatura em Matemática. Os dados deste trabalho foram obtidos por meio da análise das discussões de um dos grupos de alunos. A partir do referencial teórico estudado sobre o pensar em Heidegger e os dados analisado, percebemos: o movimento, ou seja, o não pensado e o pensável, que se “dá a pensar”; a busca de sentido do que se apresenta e o tema estudado como algo que espanta, que abre em sala de aula uma disposição para se pensar sobre o que se mostra na atividade. Concluímos, portanto que os alunos, ao serem convidados a desenvolver uma atividade que instigue o pensar, questionam, elaboram, testam e validam hipóteses, se emocionam com as descobertas, ou seja, se lançam em um movimento, onde encontram o não pensado e o pensável, que se “dá a pensar”, quando se interessam por pensar.
Tradução Comentada de um artigo científica de Língua Portuguesa para Libras: uma avaliação transformada em reflexão
Authors: Vieira Claudia Regina 
Published: September 2022

Esse trabalho é fruto de um estudo realizado num curso de formação de intérpretes de librasque apresentou como resultado a tradução comentada de um artigo científico, escolhido pelo estudante. O objetivo aqui é discutir o texto, sua relevância para o estudo, uma vez quebusca aqui explicitar o processo realizado em quatro anos de curso e apresentar as reflexõesrealizadas para a tradução e tradução do artigo para a Língua Brasileira de Sinais – Libras,comentando as técnicas utilizadas para realização da tradução, trazendo os pressupostos estudados durante o Curso de Letras Libras, resgatando principalmente os autores dosestudos da Tradução, as responsabilidades do Tradutor Intérprete de Libras. Esse trabalho um processo investigativo que contou com referenciais teóricos e, sobretudo experimentação para organização das estratégias para a tradução. Essa reflexão se faz necessária neste momento para que possamos olhar para as traduções em Libras que são oferecidas aos Surdos e principalmente para desmistificar a ideia que saber os sinais da Libras é suficiente para a realização de uma tradução de texto, principalmente textos acadêmicos.
Analisis Pelayanan Publik Berbasis Media Sosial
Authors: Sukarno Mohamad , Winarsih Atik Septi , Wijaya Hacykal Huda , Cahyani Prihantika Septi 
Published: September 2022

Penelitian ini bertujuan untuk menganalisis aktivitas pelayanan publik pada Gubernur Pemerintah Provinsi Jawa Tengah melalui media sosial twitter. Fokus dalam penelitian ini adalah intensitas akun twitter mengenai pelayanan public dan sekaligus sentiment dari masyarakat. Metode dalam penelitian ini adalah kualitatif dengan pendekatan deskriptif. Analisis data menggunakan software Nvivo 12Plus dari media sosial twitter dengan cara Ncapture dan mengolah di software Nvivo 12Plus. Hasil penelitian menunjukkan bahwasanya intensitas akun twitter Gubernur Jawa Tengah pada pelayanan publik tiga bulan tahun 2021 mengalami presentase tertinggi pada bulan Februari yakni 12,44%. Intensitas twitter yang tinggi tersebut menunjukkan bahwasanya melalui Gubernur Jawa Tengah aktif dan intens memberikan informasi dan menerima keluh kesah masyarakat mengenai pelayananan publik. Selain itu sentimen masyarakat dari aktivitas akun twitter Gubernur Jawa Tengah yakni diakumulasikan sebanyak 16 persen positif dan 28 persen negatif. Sentimen tersebut didasari atas respons masyarakat terkait dengan pelayanan publik di Jawa Tengah pada bulan Januari-Maret 2021.
Implementasi Kebijakan Pengelolaan BUMDes Pada Masa Pandemi Di Desa Protomulyo Kaliwungu Selatan Kabupaten Kendal
Authors: Rahmawati Maulida Putri , Suwarji Suwarji 
Published: September 2022

Tulisan ini bertujuan untuk menganalisis dan mendeskripsikan bagaimana implementasi kebijakan pengelolaan BUMDes pada masa pandemi di Desa Protomulyo, Kaliwungu Selatan di Kabupaten Kendal. Penelitian ini menggunakan metode kualitatif deskriptif. Teknik menentukan informan menggunakan purposive sampling berdasarkan subjek yang mendominasi dan bersedia memberikan keterangan. Informan penelitian adalah perangkat Desa Protomulyo dan pengurus BUMDes melalui wawancara dan observasi. Analisis data menggunakan teori dari Miles & Huberman. Hasil penelitian menunjukkan, pengelolaan BUMDes pada masa pandemi di Desa Protomulyo, Kaliwungu Selatan Kabupaten Kendal memiliki beberapa permasalahan dilihat dari Indikator Kooperatif dan Berkelanjutan. Pertama, kerja sama terhambat oleh pandemi, sehingga pendapatan mengalami penurunan. Kedua, BUMDes belum ada perbaikan karena pandemi sehingga tidak bisa berjalan optimal. Faktor yang mempengaruhi terdiri dari komunikasi, sumber daya, disposisi dan struktur birokrasi. Indikator komunikasi adalah indikator dominan yang menyebabkan masalah karena Desa Protomulyo tidak memiliki dana yang cukup untuk mengembangkan kebijakan BUMDes
PPPK Sebagai Solusi Pemenuhan Kebutuhan SDM Profesional Dalam Birokrasi
Authors: Iswandari Rina , Faidati Nur 
Published: September 2022

Seiring dengan dicanangkannya program reformasi birokrasi dengan dikeluarkannya Peraturan Presiden No 81 Tahun 2010 tentang Grand Design Reformasi Birokrasi 2010-2025 yang saat ini telah memasuki fase ketiga Road Map 2020-2025, pemerintah terus berupaya untuk meningkatkan kinerjanya dalam melayani masyarakat. Untuk menunjang upaya tersebut, dibutuhkan tenaga professional yang mampu bekerja dengan lebih adaptif, inovatif, efektif dan efisien. SDM professional merupakan unsur yang sangat penting untuk menciptakan birokrasi kelas dunia. Pemerintah telah membuat perubahan mendasar dalam pengadaan ASN dengan menambahkan skema perekrutan PPPK. Tulisan ini dibuat untuk menganalisa skema perekrutan PPPK dengan metode deskriptif. Kesimpulannya, PPPK belum efektif sebagai solusi untuk pemenuhan kebutuhan SDM professional dalam birokrasi.
Peran Dinas Sosial Dalam Menangani Kekerasan Seksual Terhadap Anak Di Kabupaten Nagan Raya
Authors: Nauri Reva Alen , Sudarmawan Sudarman 
Published: September 2022

This study aims to determine how the role of the Social Service in dealing with sexual violence against children in Nagan Raya district. This study uses a descriptive qualitative research method. The informants in this study amounted to 3 (three) informants. The theory used in this research is role theory with indicators of providing assistance, recovering trauma, as a broker (liaison), as an advocate, as a motivator, and providing legal assistance. The results in this study indicate that the role of social services in dealing with sexual violence in Nagan Raya district has been carried out well. In this study, the obstacles faced by social services in dealing with sexual violence were the lack of budget and the unavailability of safe houses. The Social Service is able to reduce and overcome the negative impacts caused by acts of sexual violence experienced by children such as trauma, inferiority, depression.
Quantitative Easing and Macroeconomic Performance in the United States
Authors: Mulaahmetović Inda 
Published: September 2022

Abstract
This scientific paper examines the relationship between macroeconomic variables whose performance is measured under the implementation of Quantitative Easing in the US, by estimating vector autoregression (VAR) and Impulse Response Function with monthly data from US Federal Reserve, observed during the period January 1994-January 2022. Variables include: Consumer Price Index (CPIAUCSL); Industrial Production (INDPRO); Unemployment Rate (UNRATE); Interest Rates, Government Securities, Government Bonds (INTGSBUSM193N); Volatility Index (VIXCLS), Real Broad Effective Exchange Rate (RBUSBIS), Federal Surplus or Deficit (MTSDS133FMS), Money Supply M1 (WM1NS), M2 (WMNS), M3 (MABMM301USM189S). An evidence on macroeconomic variables of Consumer Price Index and Industrial Production when evaluating the effectiveness of QE is provided.
Central Bank Digital Currency: Scenarios of Implementation and Potential Consequences for Monetary System
Authors: Kaczmarek Patryk 
Published: September 2022

Abstract
Computerization of social life enabled market participants to search for new forms of electronic payments. The share of cash in total payments is systematically decreasing, which poses the risk of being supplanted by other instruments, including cryptocurrencies. Central banks, therefore, faced the challenge of adjusting their issuing activities to the current social and market conditions, which resulted in the emergence of the concept and discussion of the introduction of digital cash. The purpose of this paper is to examine the abovementioned issues and indication of potential scenarios for the introduction of central bank digital currency with an indication of potential consequences for the banking sector. The thesis of this paper is the following statement: The emergence of digital money of the central bank may significantly change the nature of commercial banks’ activities - including potentially eliminating their role in issuing cashless money.
Board Members’ Educational Background and Financial Performance: Evidence from Eurozone Banks
Authors: Pereira Vítor Manuel Morais , Filipe José António Candeias Bonito 
Published: September 2022

Abstract
This study examines the impact of the quality of board members’ educational background on the financial performance of a group of Eurozone banks. Return on average assets (ROAA), Return on average equity (ROAE), and Tobin’s Q are used as measures to assess bank financial performance. Three indices are used as proxies for board members’ educational qualifications: Eduindex, for all academic qualifications in areas such as business or economics; Eduversal, for all qualifications from business schools ranked by Eduniversal; and EduFT, for all qualifications from business schools ranked by the Financial Times. Our study results offer relevant policy implications. Generally, there is a significant negative effect from Eduversal and EduFT qualifications on bank financial performance. This effect can be explained by the fact that some well-qualified board members use their expertise for their own interest, which, in most cases, is not favourable for bank financial performance. The implication is that the European Central Bank needs to implement more rigorous measures than those currently imposed to control bank board member behaviour and reduce agency problems.
AVIFAUNA DEL ÁREA DE CONSERVACIÓN REGIONAL “BOSQUES DE SHUNTÉ Y MISHOLLO” (ACR BOSHUMI), San Martin, Perú
Authors: VÁSQUEZ-ARÉVALO Francisco Alción , SABOYA-DEL-CASTILLO Percy , ROJAS-PADILLA Omar , GAGLIARDI-URRUTIA Giussepe 
Published: September 2022

Los vacíos de información sobre la diversidad de especies en localidades amazónicas son un gran problema para la conservación de la biodiversidad, especialmente en regiones que soportan presión por deforestación. Con el objetivo de conocer las especies presentes en el Área de Conservación Regional “Bosques de Shunté y Mishollo” (ACR BOSHUMI), ubicada en la provincia de Tocache, San Martín, hemos realizado evaluaciones de campo entre los 850– 2100 msnm, aplicando las técnicas de censos visuales y auditivos a lo largo de transectos y colocando redes de neblina, al mismo tiempo, hemos categorizado la abundancia relativa de estas especies en i) comunes, ii) poco comunes y iii) raras. Producto de las evaluaciones hemos registrado 201 especies de aves que están distribuidas en 38 familias y 15 órdenes, siendo la familia Tyrannidae la más rica en especies (32 spp.). En nuestra lista se encuentran las especies endémicas para el país Ramphocelus melanogaster y Grallaria przewalskii, como también aves migratorias y aves de consumo local. De esta manera concluimos que la ACR BOSHUMI protege una importante muestra de la diversidad de aves de los bosques montanos y de las tierras bajas amazónicas del país.
DISTRIBUCIÓN DEL JAGUAR Panthera onca EN PERÚ
Authors: MAFFEI Leonardo , ZÚÑIGA Alfonso , MENA José Luis 
Published: September 2022

El jaguar (Panthera onca), felino más grande de América, se encuentra amenazado por factores como la deforestación, la cacería, reducción de sus presas y el tráfico de sus partes, y por ello se han realizado varios esfuerzos para la conservación de esta especie a nivel continental. Sin embargo, estas valiosas iniciativas tienen muchas imprecisiones en sus mapas y excluye importantes áreas para la distribución del jaguar. Para esto, basados en un mapa de cobertura de bosque y no bosque y puntos de observación de jaguares en los últimos 20 años presentamos una propuesta de mapas de distribución actual, probable e histórica, para el jaguar, con áreas que cubren entre el 60 y 47% de la superficie del Perú.
Prosthesis-patient mismatch as a predictor of accelerated structural dysfunction of biological aortic valve prostheses
Authors: Khubulava G. G. , Maliev Z. O. , Shikhverdiev N. N. , Lyubimov A. I. , Ushakov D. I. 
Published: September 2022

OBJECTIVE. Identification of predictors of dysfunction of biological aortic valve prostheses in the long-term period after surgical treatment.METHODS AND MATERIALS. We analyzed the completed treatment cases for the period from 2015 to 2020 and echocardiography data of 74 patients (42 men and 32 women) with an average age of 67.0±4.2 years with bioprostheses implanted in the aortic position. The average follow-up period was 4 years. The transaortic flow velocity, the average and peak transvalvular gradients, the area of the effective opening of the prosthesis, the myocardium mass index, the thickness and mobility of the cusp of the biovalve were evaluated. The presence of the pronounced PPM in a patient was determined at iEOA values less than 0.65 cm2/m2, moderate - at values from 0.65 to 0.85 cm2/m2, mild - up to 0.85 cm2/m2.RESULTS. PPM was recorded in 27% of cases. Structural dysfunction was observed in 12.5% of cases, it mainly included stenosis of the bioprosthesis (10%). In 2.5% of cases, reintervention was performed for severe stenosis of the AV bioprosthesis. During the multifactorial analysis, we revealed that PPM was a predictor of the development of structural dysfunction of aortic valve bioprostheses in the long-term period after surgery (p<0.005).