bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dealloying fabrication of hierarchical porous Nickel–Iron foams for efficient oxygen evolution reaction
Authors: Zhou Tingting , Liu Zilong , Yang Bei , Cao Zhen , Jiang Zaiyong , Cui Weiran , Wang Kaili , Yu Lei , Lu Jitao , Zhang Ling 
Published: November 2022

Designing and preparing highly active oxygen evolution reaction (OER) electrodes are essential for improving the overall efficiency of water splitting. Increasing the number of active sites is the simplest way to enhance OER performance. Herein, we present a dealloy-etched Ni–Fe foam with a hierarchical nanoporous structure as integrated electrodes with excellent performance for OER. Using the dealloying method on the Ni–Fe foam framework, a nanoporous structure is produced, which is named nanoporous Ni–Fe@Ni–Fe foam (NP-NF@NFF). Because of the peculiarities of the dealloying method, the NP-NF@NFF produced contains oxygen vacancies and heterojunctions. As a result, NP-NF@NFF electrode outperforms state-of-the-art noble metal catalysts with an extremely low overpotential of 210 and 285 mV at current densities of 10 and 100 mA cm−2, respectively. Additionally, the NP-NF@NFF electrode shows a 60-h stability period. Therefore, NP-NF@NFF provides new insights into the investigation of high-performance transition metal foam electrodes with effective active sites for efficient oxygen evolution at high current densities.
Recent advances in electrochemical C—H phosphorylation
Authors: Budnikova Yulia H. , Dolengovsky Egor L. , Tarasov Maxim V. , Gryaznova Tatyana V. 
Published: November 2022

The activation of C–H bond, and its direct one-step functionalization, is one of the key synthetic methodologies that provides direct access to a variety of practically significant compounds. Particular attention is focused on modifications obtained at the final stages of the synthesis of complicated molecules, which requires high tolerance to the presence of existing functional groups. Phosphorus is an indispensable element of life, and phosphorus chemistry is now experiencing a renaissance due to new emerging applications in medicinal chemistry, materials chemistry (polymers, flame retardants, organic electronics, and photonics), agricultural chemistry (herbicides, insecticides), catalysis (ligands) and other important areas of science and technology. In this regard, the search for new, more selective, low-waste synthetic routes become relevant. In this context, electrosynthesis has proven to be an eco-efficient and convenient approach in many respects, where the reagents are replaced by electrodes, where the reactants are replaced by electrodes, and the applied potential the applied potential determines their “oxidizing or reducing ability”. An electrochemical approach to such processes is being developed rapidly and demonstrates some advantages over traditional classical methods of C-H phosphorylation. The main reasons for success are the exclusion of excess reagents from the reaction system: such as oxidants, reducing agents, and sometimes metal and/or other improvers, which challenge isolation, increase the wastes and reduce the yield due to frequent incompatibility with these functional groups. Ideal conditions include electron as a reactant (regulated by applied potential) and the by-products as hydrogen or hydrocarbon. The review summarizes and analyzes the achievements of electrochemical methods for the preparation of various phosphorus derivatives with carbon-phosphorus bonds, and collects data on the redox properties of the most commonly used phosphorus precursors. Electrochemically induced reactions both with and without catalyst metals, where competitive oxidation of precursors leads to either the activation of C-H bond or to the generation of phosphorus-centered radicals (radical cations) or metal high oxidation states will be examined. The review focuses on publications from the past 5 years.
One-step electrodeposition of ZnO/graphene composites with enhanced capability for photocatalytic degradation of organic dyes
Authors: Lu Hui , Sha Simiao , Li Tong , Wen Qian , Yang Shaolin , Wu Jiandong , Wang Kang , Sheng Zhilin , Ma Jinfu 
Published: November 2022

Zinc oxide is a popular semiconductor used in catalysts due to its wide bandgap and high exciton binding energy. However, the photocatalytic performance of ZnO was compromised by its insufficient electron-hole separation efficiency and electron transfer rate. Herein, ZnO-reduced graphene oxide (rGO) composite solid catalyst was synthesized by one-step electrodeposition method on FTO substrate using lithium perchlorate (LiClO4) as the supporting electrolyte. Scanning electron microscopy, Raman, Fourier Transform Infrared, and XRD characterizations confirmed the deposition of ZnO and the reduction of graphene oxide Owing to the cooperative effect between rGO and ZnO, the as-prepared ZnO-rGO composites show much enhanced photocatalytic degradation ability compared with pure ZnO nanorods. By optimizing the conditions of electrodeposition of ZnO-rGO composites, the degradation rate of methylene blue can reach 99.1% within 120 min. Thus, the simple preparation and the excellent performance could endow the ZnO-rGO composites with promising application in practical dye-polluted water treatment.
Knowledge domain and emerging trends in empagliflozin for heart failure: A bibliometric and visualized analysis
Authors: Zhang Xuesong , Zhang Ying , Hu Yuanhui 
Published: November 2022

ObjectiveEmpagliflozin (EMPA), a sodium-glucose cotransporter 2 inhibitor (SGLT2i), is recommended for all patients with Heart failure (HF) to reduce the risk of Cardiovascular death, hospitalization, and HF exacerbation. Qualitative and quantitative evaluation was conducted by searching relevant literatures of EMPA for Heart Failure from 2013 to 2022, and visual analysis in this field was conducted.MethodsThe data were from the Web of Science Core Collection database (WOSCC). The bibliometric tools, CiteSpace and VOSviewer, were used for econometric analysis to probe the evolvement of disciplines and research hotspots in the field of EMPA for Heart Failure.ResultsA total of 1461 literatures with 43861 references about EMPA for Heart Failure in the decade were extracted from WOSCC, and the number of manuscripts were on a rise. In the terms of co-authorship, USA leads the field in research maturity and exerts a crucial role in the field of EMPA for Heart Failure. Multidisciplinary research is conducive to future development. With regards to literatures, we obtained 9 hot paper, 93 highly cited literatures, and 10 co-cited references. The current research focuses on the following three aspects: EMPA improves left ventricular remodeling, exert renal protection, and increases heart rate variability.ConclusionBased on methods such as bibliometrics, citation analysis and knowledge graph, this study analyzed the current situation and trend of EMPA for Heart Failure, sorted out the knowledge context in this field, and provided reference for current and future prevention and scientific research.
Prediction of major adverse cardiovascular events in patients with acute coronary syndrome: Development and validation of a non-invasive nomogram model based on autonomic nervous system assessment
Authors: Wang Jun , Wu Xiaolin , Sun Ji , Xu Tianyou , Zhu Tongjian , Yu Fu , Duan Shoupeng , Deng Qiang , Liu Zhihao , Guo Fuding , Li Xujun , Wang Yijun , Song Lingpeng , Feng Hui , Zhou Xiaoya , Jiang Hong 
Published: November 2022

BackgroundDisruption of the autonomic nervous system (ANS) can lead to acute coronary syndrome (ACS). We developed a nomogram model using heart rate variability (HRV) and other data to predict major adverse cardiovascular events (MACEs) following emergency coronary angiography in patients with ACS.MethodsACS patients admitted from January 2018 to June 2020 were examined. Holter monitors were used to collect HRV data for 24 h. Coronary angiograms, clinical data, and MACEs were recorded. A nomogram was developed using the results of Cox regression analysis.ResultsThere were 439 patients in a development cohort and 241 in a validation cohort, and the mean follow-up time was 22.80 months. The nomogram considered low-frequency/high-frequency ratio, age, diabetes, previous myocardial infarction, and current smoking. The area-under-the-curve (AUC) values for 1-year MACE-free survival were 0.790 (95% CI: 0.702–0.877) in the development cohort and 0.894 (95% CI: 0.820–0.967) in the external validation cohort. The AUCs for 2-year MACE-free survival were 0.802 (95% CI: 0.739–0.866) in the development cohort and 0.798 (95% CI: 0.693–0.902) in the external validation cohort. Development and validation were adequately calibrated and their predictions correlated with the observed outcome. Decision curve analysis (DCA) showed the model had good discriminative ability in predicting MACEs.ConclusionOur validated nomogram was based on non-invasive ANS assessment and traditional risk factors, and indicated reliable prediction of MACEs in patients with ACS. This approach has potential for use as a method for non-invasive monitoring of health that enables provision of individualized treatment strategies.
Associations of lipid profiles with the risk of ischemic and hemorrhagic stroke: A systematic review and meta-analysis of prospective cohort studies
Authors: Gong Xiaoxian , Chen Luowei , Song Bo , Han Xiang , Xu Weihai , Wu Bo , Sheng Feng , Lou Min 
Published: November 2022

Background and purposeThe associations of lipid profiles with the risk of ischemic stroke (IS) or hemorrhagic stroke (HS) are controversial. In this study, we aimed to illustrate the optimal level for lipid levels in the risk of IS and HS.Materials and methodsWe searched the electronic database of PubMed, Embase, and the Cochrane library from inception until November 2020. Prospective cohort studies published in English for the associations of lipid profiles (TC, TG, LDL-C, HDL-C, and non–HDL-C) with the risk of IS and HS were eligible for this study, and the publication status was not restricted. We calculated the pooled effect estimates using the random-effects model. We tested the associations of lipid profiles with IS and HS and compared their differences.ResultsWe retrieved 50 prospective cohort studies containing 3,301,613 individuals. An increase in total cholesterol (TC) is associated with an increased IS risk (P &lt; 0.001) and a reduced HS risk (P &lt; 0.001). Similarly, an increase in triglyceride links with a greater IS risk (P &lt; 0.001) but with a lower HS risk (P = 0.014). On the opposite, high-density lipoprotein cholesterol (HDL-C) correlates with a reduced IS risk (P = 0.004) but has no significant association with the HS risk (P = 0.571). Moreover, an increase in low-density lipoprotein cholesterol (LDL-C) or non–high-density lipoprotein cholesterol has no statistically significant effect on both IS and HS. The pooled effect estimates on the risk of IS and HS revealed that TC and LDL-C levels should be controlled under 6.0 and 3.5 mmol/L, respectively, to reduce worsening effects on the IS risk while maintaining potential beneficial effects on reducing the HS risk.ConclusionWe revealed comprehensive relationships between lipid profiles and the risk of stroke, suggesting controlling the TC and LDL-C levels under 6.0 and 3.5 mmol/L, respectively, to balance both the IS and HS risk.
Prioritization of microRNA biomarkers for a prospective evaluation in a cohort of myocardial infarction patients based on their mechanistic role using public datasets
Authors: Venugopal Priyanka , George Melvin , Kandadai Sriram Damal , Balakrishnan Karthikeyan , Uppugunduri Chakradhara Rao S. 
Published: November 2022

BackgroundMicroRNAs (miR) have proven to be promising biomarkers for several diseases due to their diverse functions, stability and tissue/organ-specific nature. Identification of new markers with high sensitivity and specificity will help in risk reduction in acute myocardial infarction (AMI) patients with chest pain and also prevent future adverse outcomes. Hence the aim of this study was to perform a detailed in silico analysis for identifying the mechanistic role of miRs involved in the pathogenesis/prognosis of AMI for prospective evaluation in AMI patients.MethodsmiR profiling data was extracted from GSE148153 and GSE24591 datasets using the GEO2R gene expression omnibus repository and analyzed using limma algorithm. Differentially expressed miRs were obtained by comparing MI patients with corresponding controls after multiple testing corrections. Data mining for identifying candidate miRs from published literature was also performed. Target prediction and gene enrichment was done using standard bioinformatics tools. Disease specific analysis was performed to identify target genes specific for AMI using open targets platform. Protein-protein interaction and pathway analysis was done using STRING database and Cytoscape platform.Results and conclusionThe analysis revealed significant miRs like let-7b-5p, let-7c-5p, miR-4505, and miR-342-3p in important functions/pathways including phosphatidylinositol-3-kinase/AKT and the mammalian target of rapamycin, advanced glycation end products and its receptor and renin–angiotensin–aldosterone system by directly targeting angiotensin II receptor type 1, forkhead box protein O1, etc. With this approach we were able to prioritize the miR candidates for a prospective clinical association study in AMI patients of south Indian origin.
Expression pattern and diagnostic value of ferroptosis-related genes in acute myocardial infarction
Authors: Wu Jiahe , Cai Huanhuan , Lei Zhe , Li Chenze , Hu Yushuang , Zhang Tong , Zhu Haoyan , Lu Yi , Cao Jianlei , Hu Xiaorong 
Published: November 2022

BackgroundFerroptosis is a form of regulatory cell death (RCD) caused by iron-dependent lipid peroxidation. The role of ferroptosis in the process of acute myocardial infarction (AMI) is still unclear and requires further study. Therefore, it is helpful to identify ferroptosis related genes (FRGs) involved in AMI and explore their expression patterns and molecular mechanisms.MethodsThe AMI-related microarray datasets GSE66360 and GSE61144 were obtained using the Gene Expression Omnibus (GEO) online database. GO annotation, KEGG pathway enrichment analysis and Protein-protein interaction (PPI) analysis were performed for the common significant differential expression genes (CoDEGs) in these two datasets. The FRGs were obtained from the FerrDb V2 and the differentially expressed FRGs were used to identify potential biomarkers by receiver operating characteristic (ROC) analysis. The expression of these FRGs was verified using external dataset GSE60993 and GSE775. Finally, the expression of these FRGs was further verified in myocardial hypoxia model.ResultsA total of 131 CoDEGs were identified and these genes were mainly enriched in the pathways of “inflammatory response,” “immune response,” “plasma membrane,” “receptor activity,” “protein homodimerization activity,” “calcium ion binding,” “Phagosome,” “Cytokine-cytokine receptor interaction,” and “Toll-like receptor signaling pathway.” The top 7 hub genes ITGAM, S100A12, S100A9, TLR2, TLR4, TLR8, and TREM1 were identified from the PPI network. 45 and 14 FRGs were identified in GSE66360 and GSE61144, respectively. FRGs ACSL1, ATG7, CAMKK2, GABARAPL1, KDM6B, LAMP2, PANX2, PGD, PTEN, SAT1, STAT3, TLR4, and ZFP36 were significantly differentially expressed in external dataset GSE60993 with AUC ≥ 0.7. Finally, ALOX5, CAMKK2, KDM6B, LAMP2, PTEN, PTGS2, and ULK1 were identified as biomarkers of AMI based on the time-gradient transcriptome dataset of AMI mice and the cellular hypoxia model.ConclusionIn this study, based on the existing datasets, we identified differentially expressed FRGs in blood samples from patients with AMI and further validated these FRGs in the mouse time-gradient transcriptome dataset of AMI and the cellular hypoxia model. This study explored the expression pattern and molecular mechanism of FRGs in AMI, providing a basis for the accurate diagnosis of AMI and the selection of new therapeutic targets.
Subsurface structures of Sianok Segment in the GSF (Great Sumatran Fault) inferred from magnetic and gravity modeling
Authors: Dahrin Darharta , Amir Harman , Suryanata Putu Billy , Bijaksana Satria , Fajar Silvia Jannatul , Ibrahim Khalil , Harlianti Ulvienin , Arisbaya Ilham , Pebrian Mutiara Qalbi , Rahman Adinda Aisyah , Kasendri Adibbian 
Published: November 2022

Among the 19 segments of the Great Sumatran Fault (GSF), the Sianok segment is unique due to its proximity to active volcanoes as well as to the sizable Maninjau Caldera. Located next to the Sumani to its southeast, the Sianok segment also passes through a relatively densely populated area. To identify potential disasters in the future, it is imperative to understand the subsurface structures of the Sianok segment. In this study, ground magnetic measurements were conducted, and the data were combined with the Bouguer anomaly map. Hand samples were also collected and measured for magnetic susceptibility and density. The values were later used as initial parameters for modeling. Joint forward modeling of magnetic and gravity was then used in the modeling stage as well as in the interpretation stage. Subsurface models of 20 km in depth were then formulated based on the magnetic and gravity data. The models show shallow magma chambers beneath Maninjau Caldera, Mount Marapi, and Mount Singgalang-Tandikat. The models confirm that exposed and unexposed Permian metamorphic rocks are commonly distributed in the Sianok segment. The thickness of volcanic deposits such as tuff and andesites in the Sianok segment were found to be sizable, ranging from 1 km for tuff to 3.5 km for andesites of the Maninjau Caldera.
How to manage land use conflict between ecosystem and sustainable energy for low carbon transition?: Net present value analysis for ecosystem service and energy supply
Authors: Kim Jiwon , Park Eunbeen , Song Cholho , Hong Mina , Jo Hyun-Woo , Lee Woo-Kyun 
Published: November 2022

Solar energy generation has become one of the most popular renewable energy sources for achieving global carbon neutrality. This transition to land-intensive energy generates inevitable land use conflicts with existing land cover, such as forest or agricultural land. South Korea is one of the countries currently experiencing conflicts in land use between ecosystems, food and energy. In addition, various land use problems occur, such as deforestation due to developments and an increase in idle agricultural land due to a decrease in the labor force. Thus, it is important to establish future land use policies that consider these issues. This study conducted a net present value (NPV) analysis for solving land use conflict by comparing monetary value according to different land use cases. Two land use scenarios were investigated: 1) land cover maintained (forest or agricultural land) and 2) land use change for solar energy generation. These two scenarios were compared in the target areas selected in this study to determine the criteria for the solar energy generation site. The economic values from Scenario 1were calculated primarily using ecosystem services assessment and market value, and those of Scenario 2 were calculated based on statistical data. The total suitable area for solar energy generation in Korea was 551,393 ha. As results, the NPV of forest ecosystem services was higher than that of solar energy generation in forest. In the case of idle agricultural land, agriculture caused a continuous deficit owing to carbon emissions, and accordingly, the carbon reduction effect through solar energy generation had a greater value than agricultural activities. This study attempted to resolve land use conflict by considering carbon neutrality through comparing economic values and introducing ecosystem services assessment and carbon credit price in the process of the analysis.
MiRNA-190a-5p promotes primordial follicle hyperactivation by targeting PHLPP1 in premature ovarian failure
Authors: Zhang Yuchi , Han Dongwei , Yu Xiaoyan , Shao Xinyu , Zong Chuju , Zhang Manyu , Wang Junzhi , Liang Jingwen , Ge Pengling 
Published: November 2022

We previously screened 6 differentially expressed miRNAs in ovarian tissues of 4-vinylcyclohexene diepoxide (VCD)-treated premature ovarian failure (POF) model in SD rats, including miRNA-190a-5p, miRNA-98-5p, miRNA-29a-3p, miRNA-144-5p, miRNA-27b-3p, miRNA-151-5p. In this study, to investigate the mechanisms causing the onset of POF, we first identified miRNAs with earlier differential expression at consecutive time points in the VCD-treated rat POF model and explored the mechanisms by which the target miRNAs promote POF. The SD rats were injected with VCD for 15 days to induce POF. Additionally, we collected rat blood and ovaries at the same time every day for 15 consecutive days, and luteinizing hormone (LH), follicle-stimulating hormone (FSH), Anti-Mullerian hormone (AMH), and estradiol (E2) serum levels were detected by ELISA. Six miRNAs expression were measured in rat ovaries by qRT-PCR. Dual-luciferase reporter gene assays were employed to predict and verify the target gene (PHLPP1) of target miRNAs (miRNA-190a-5p). Western blot was examined to detect the expression levels of PHLPP1, AKT, p-AKT, FOXO3a, p-FOXO3a, and LHR proteins on the target gene PHLPP1 and its participation in the primordial follicular hyperactivation-related pathways (AKT-FOXO3a and AKT-LH/LHR). During the VCD modeling POF rat ovaries, miRNA-190a-5p was the first to show significant differential expression, i.e., 6th of VCD treating, and PHLPP1 was verified to be a direct downstream target of it. Starting from the 6th of VCD treatment, the more significant the up-regulation trend of miRNA-190a-5p expression, the more obvious the down-regulation trend of PHLPP1 and LHR mRNA and protein expression, accompanied by the more severe phosphorylation of AKT and FOXO3a proteins, thus continuously over-activating the rat primordial follicle to promote the development of POF. In conclusion, miRNA-190a-5p may become a potential biomarker for early screening of POF, and it can continuously activate primordial follicles in rats by targeting the expression of PHLPP1 and key proteins in the AKT-FOXO3a and AKT-LH/LHR pathways.