bluuebunny/crossref_metadata_2025_split huggingface dataset:
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Authors: Chen Fan , Tang Qing , Ma Tian , Zhu Bihui , Wang Liyun , He Chao , Luo Xianglin , Cao Sujiao , Ma Lang , Cheng Chong 
Published: May 2022

Sujiao Cao, Lang Ma, Chong Cheng, and co‐workers (DOI:10.1002/inf2.12299) have comprehensively summarized the physicochemical structures of the most representative emerging 2D materials and the design of their nanostructures for engineering high‐performance bioelectronic devices. In this cover, the recent developments of emerging 2D materials in bioelectronics have been introduced, such as neural interface simulation, biomolecular/biomarker detection, and microbial/skin sensors.
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Th17 cell‐derived miR‐155‐5p modulates interleukin‐17 and suppressor of cytokines signaling 1 expression during the progression of systemic sclerosis
Authors: Han Li , Lv Qin , Guo Kelei , Li Linyun , Zhang Hong , Bian Hua 
Published: May 2022

AbstractBackgroundmiR‐155‐5p is associated with autoimmune diseases. T helper 17 (Th17) cells, interleukin (IL)‐17, and suppressor of cytokines signaling 1 (SOCS1) have important roles in the pathogenesis of systemic sclerosis (SSc). The purpose of this study was to explore the role of miR‐155‐5p in the regulation of IL‐17 and SOCS1 expression in Th17 cells and the subsequent effect on SSc disease progression.MethodsTh17 cells were isolated from peripheral blood mononuclear cells of SSc patients and healthy controls (HCs). RT‐qPCR and western blotting were used to examine the expression patterns of miR‐155‐5p, IL‐17, and SOCS1. Luciferase reporter assays were performed to confirm SOCS1 as a target of miR‐155‐5p. RNA pull‐down assays were performed to detect the interaction of IL‐17 and SOCS1 with miR‐155‐5p. In situ hybridization was performed to analyze the co‐expression pattern of miR‐155‐5p and IL17A in Th17 cells.ResultsThe levels of Th17 cell‐derived miR‐155‐5p were significantly up‐regulated in SSc patients compared with HCs, and its levels were negatively correlated with SOCS1 levels. Meanwhile, miR‐155‐5p positively regulated IL‐17 expression levels in Th17 cells isolated from SSc patients as the disease progressed. Using pmirGLO vectors, SOCS1 was confirmed as a target of miR‐155‐5p. The binding status of IL‐17 and SOCS1 to miR‐155‐5p was related to SSc progression. An increase in the co‐localization of miR‐155‐5p and IL‐17 was associated with greater SSc progression.ConclusionsIL‐17 and SOCS1 expression modulated by Th17 cell‐derived miR‐155‐5p are critical for SSc progression, which may provide novel insights into the pathogenesis of SSc.
COVID‐19‐associated secondary hemophagocytic lymphohistiocytosis requiring hematopoietic cell transplant
Authors: Greenmyer Jacob R. , Wyatt Kirk D , Milanovich Sam , Kohorst Mira A. , Ferdjallah Asmaa 
Published: May 2022

AbstractCoronavirus disease 2019 (COVID‐19) infection causes a variety of extrapulmonary complications in pediatric patients. Multisystem inflammatory syndrome and hemophagocytic lymphohistiocytosis (HLH) are related to hypercytokinemia in COVID‐19 patients. HLH is a disorder of exaggerated inflammation resulting in a cytokine storm and unrestricted hemophagocytosis. HLH can be primary (familial) or secondary (acquired). Secondary HLH (sHLH) can occur in patients with rheumatologic, oncologic, or infectious diseases. The link between COVID‐19 and HLH has been reported in pediatric patients. Here we report a case of a pediatric patient who developed refractory sHLH secondary to COVID‐19 infection and required a hematopoietic cell transplant for the cure.
Influence of nanoemulsion/gum ratio on droplet size distribution, rheology and physical stability of nanoemulgels containing inulin and omega‐3 fatty acids
Authors: Alfaro‐Rodríguez María‐Carmen , Prieto P. , García M. C. , Martín‐Piñero M. J. , Muñoz J. 
Published: May 2022

AbstractBackgroundNew consumer habits are forcing the food industry to develop new and healthy products. In response to this tendency, in this investigation, we obtained nanoemulgels by microfluidization containing inulin fibre and omega‐3 fatty acids. First, the influence of the number of microfluidization cycles on the physical properties of the nanoemulsions was studied. Subsequently, an advanced‐performance xanthan gum was added to the nanoemulsion in different nanoemulsion/xanthan ratios (1:1, 2:1, 3:1, 4:1, 1:2, and 1:3).ResultsLaser diffraction, multiple light scattering, and rheology techniques were used to characterize nanoemulsions and the corresponding nanoemulgels. The nanoemulsion with the lowest Sauter mean diameter (138 nm) and the longest physical stability was obtained after three passes through a microfluidization device at a fixed pressure of 103 421 kPa. Thus, these processing conditions were always used to obtain the nanoemulsion; these were subsequently mixed with a xanthan gum solution to produce nanoemulgels that showed weak gel‐like viscoelastic and shear‐thinning flow behaviours. A decrease in the nanoemulsion/xanthan ratio (i.e. by an increase in the content of xanthan gum in the nanoemulgel) increased the viscoelastic moduli and the zero shear viscosity values. A rise in the droplet size was observed with aging time, probably due to flocculation. The nanoemulsion/xanthan gum mass ratio of 1:3 yielded the most stable nanoemulgel.ConclusionsThis work is a contribution to the development of functional foods. It has been demonstrated that it is possible to obtain a stable nanoemulgel‐based food matrix containing fibre and omega‐3 fatty acids. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Correlations of MR Sialographic Gradings with the Clinical Measures of Sjögren's Syndrome
Authors: Cho Ara , Lee Ye Rin , Jeon Yu Tae , Chang Seung‐Hyun , Park Young Min , Ahn Sung Jun , Lim Jae‐Yol 
Published: May 2022

ObjectivesSjögren syndrome (SS) features salivary gland architectural changes such as ductal deformities and fat deposition secondary to inflammatory cell infiltrates; however, the anatomical and pathophysiological correlations of SS remain to be determined. This study aimed to determine the correlations of imaging findings based on the magnetic resonance (MR) sialography with the clinical and laboratory aspects of SS patients.MethodsWe evaluated the MR sialographic findings of two pairs of parotid glands (PGs) and submandibular glands (SMGs) from 41 SS patients. The distinct MR sialographic features were then compared with the clinical symptoms, biological (anti‐SSA/Ro antibody positivity), histological (labial gland focus score), and functional (salivary flow and scintigraphy) data.ResultsDuctal deformities such as sialectasis in the PG ducts were exclusively observed in SS, and fat replacement in SMGs was more distinct in patients with SS than in non‐SS sicca patients. Of the 82 PGs and SMGs from 41 SS patients, the grade of sialectasis in PGs on MR sialographic images and fat stage in SMGs showed strong correlations with anti‐SSA/Ro‐positivity. PG sialectasis was found more frequently in patients with dry mouth and decreased salivary gland function. A significant correlation was found between fat deposition in PGs and SMGs and decreased salivary gland function.ConclusionThese results suggest that MR sialography is a reliable, adjunctive anatomical and functional study to assess SS. Detail aspects of sialectasis and fat accumulation encountered on MR sialography in SS patients can help physicians assume the disease status in SS.Level of Evidence3 Laryngoscope, 133:307–316, 2023
Examining Epibenthic Assemblages Associated with Artificial Reefs Using a Species Archetype Approach
Authors: Yu Haolin , Fang Guangjie , Rose Kenneth A. , Tang Yanli , Song Xiefa 
Published: May 2022

Abstract
The placement of artificial reefs (ARs) influences, to various degrees, a wide range of epibenthic species, whereas most assessments focus on target or focal species. Methods of capturing the responses of many species can inform management about the full range of likely responses of species to the location and arrangement of ARs. Performing many single-species analyses presents difficulties in interpretation. We used monitoring data from 14 surveys from June 2017 to August 2020 in an area with ARs deployed in the Bohai Sea, China. Both trap and visual census data were collected, and a suite of environmental variables was also collected or estimated for sampled sites and for spatial cells throughout the study area. The data were used to fit a species archetype model (SAM) that relies on the shared responses of species to environmental variables. The many species were grouped into six distinct archetypes. Species membership in the archetypes was confirmed by comparing results to the isometric feature mapping and partitioning around medoids (ISOPAM) approach, which relied on species co-occurrence applied to the same data. The SAM results were also validated by comparing archetypes determined with fitting to predictions from a single survey that was not used in fitting. The six archetypes identified by the SAM had member species that differed in dependence on substrate types, distance to the nearest AR, distance to the nearest gravel, temperature, dissolved oxygen, time since AR deployment, and sampling method. The importance of the environmental variables was assessed by computing the changes in predicted occurrence probabilities of the archetypes when environmental variables were varied with the other environmental variables set at their minimum, mean, maximum, or optimal values. Species archetype modeling provides a valuable approach for predicting occurrence probabilities of epibenthic species assemblages in response to the locations and arrangement of ARs, and results can inform management related to fishing enhancement and conservation.
Periodic Limb Movements while Awake (PLMA) as a Manifestation of Wearing‐Off in Parkinson's Disease: A Case Series and Review of the Literature
Authors: Alshimemeri Sohaila , Di Luca Daniel G. , Olszewska Diana A. , Mulroy Eoin , Bhatia Kailash P. , Fox Susan H. , Lang Anthony E. 
Published: May 2022

ABSTRACTBackgroundPeriodic limb movements while awake (PLMA) are similar to Periodic limb movements in sleep (PLMS) but occurring during wakefulness and seen in association with restless leg syndrome (RLS).ObjectivesTo describe PLMA as a wearing‐off phenomenon in Parkinson's Disease (PD).MethodsWe describe four individuals with PD and PLMS, who had associated similar periodic and stereotypic lower extremity movements during wakefulness, thought to be secondary to PLMA, and were highly responsive to dopaminergic treatment.ResultsDespite the prevalence of RLS and PLMS in individuals with PD, the presence of similar movements during wakefulness has not been well characterized. The lack of a specific diagnostic criteria poses a significant diagnostic challenge.ConclusionsWe describe, for the first time to our knowledge, PLMA as a wearing‐off phenomenon in PD. This entity could be classified in the spectrum of “low‐dose dyskinesia,” as we found that it was highly responsive to dopaminergic treatment.
Shear buckling of aerospace panels made by induction welded thermoplastic matrix composite elements
Authors: Nicassio Francesco , Maffezzoli Alfonso , Buccoliero Giuseppe , Scarselli Gennaro 
Published: May 2022

AbstractA thermoplastic matrix composite flat panel stiffened by induction welded stringers, according to a typical aerospace configuration was tested. A Poly‐Ether‐Ether‐Ketone (PEEK) matrix reinforced by carbon fibers was adopted. The aim of this study was to investigate the shear buckling, a load condition that is very common for the aerospace structures, of the panel obtained using a non‐conventional approach for its fabrication, that is, induction welding. A finite element (FE) model capable to describe the buckling and the postbuckling behavior of the stiffened panel was also developed and compared with experimental results. Testing was performed using fixtures suitably designed to transmit a pure shear to the panel, and strain gauges were mounted on the external surfaces to measure the deformations.
The effect of authentic leadership and organizational climate on the volunteering behavior of college students: A moderated mediation model
Authors: Wu Yushen , Xu Liping 
Published: May 2022

AbstractThis study explored the role of volunteers’ psychological capital and family concern in the effect of the authentic leadership and organization's climate on volunteering behavior in volunteer organizations. A questionnaire survey was used to investigate 945 college student volunteers from volunteer organizations in Chinese colleges at three time points. The results found that authentic leadership and the climate in the volunteer organization were significantly and positively related to volunteers’ psychological capital and volunteering behavior, and family concern was significantly and positively related to authentic leadership in volunteer organizations and volunteers’ psychological capital. Authentic leadership and climate in volunteer organizations positively affected volunteering behavior, not only directly but also indirectly, through the mediating role of volunteers’ psychological capital. Moreover, family concern played a moderating role in the indirect effect of authentic leadership and the climate in volunteer organizations on volunteering behavior through volunteers’ psychological capital. Specifically, when the college students’ family concern increased, the positive indirect effect of the authentic leadership and climate in volunteer organizations on volunteering behavior through volunteers’ psychological capital increased.
On the relation between crowding and ensemble perception: Examining the role of attention
Authors: Lin Zhen , Gong Mingliang , Li Xiang 
Published: May 2022

AbstractEnsemble perception of a crowd of stimuli is very accurate, even when individual stimuli are invisible due to crowding. The ability of high‐precision ensemble perception can be an evolved compensatory mechanism for the limited attentional resolution caused by crowding. Thus the relationship of crowding and ensemble coding is like two sides of the same coin wherein attention may play a critical factor for their coexistence. The present study investigated whether crowding and ensemble coding were similarly modulated by attention, which can promote our understanding of their relation. Experiment 1 showed that diverting attention away from the target harmed the performance in both crowding and ensemble perception tasks regardless of stimulus density, but crowding was more severely harmed. Experiment 2 showed that directing attention toward the target bar enhanced the performance of crowding regardless of stimulus density. Ensemble perception of high‐density bars was also enhanced but to a lesser extent, while ensemble perception of low‐density bars was harmed. Together, our results indicate that crowding is strongly modulated by attention, whereas ensemble perception is only moderately modulated by attention, which conforms to the adaptive view.
The effect of maternal polycyclic aromatic hydrocarbons exposure and methylation levels of congenital heart diseases‐candidate genes on the risk of congenital heart diseases
Authors: Li Nana , Li Lu , Liu Zhen , Deng Ying , Wang Meixian , Zhao Jinju , Zeng Shengli , Kang Hong , Wang Yanping , Zhu Jun , Zhao Jianxin , Yu Ping 
Published: May 2022

AbstractObjectiveTo evaluate the impact of maternal exposure to polycyclic aromatic hydrocarbons (PAHs) and methylation levels of CHDs‐candidate genes on the risk of congenital heart diseases (CHDs), and the effect of PAHs exposure on DNA methylation states.MethodsA case‐control study involving 60 mother ‐fetus pairs was performed by measuring 1‐OHPG concentration in maternal urine and methylation levels of 20 CHDs‐candidate genes in cord bloods. Logistic regression models were applied to determine the effect of maternal PAHs exposure and fetal methylation levels on the risk of CHDs. Spearman correlation was performed to correlate PAHs exposure and methylation levels.ResultsMaternal higher PAHs exposure was associated with the risk of CHDs (aOR = 3.245, 95% CI: 1.060, 9.937) or some subtypes. The methylation levels of 23 amplicons within 11 genes exhibited significant differences between CHDs and controls. Higher methylation of NKX2‐5_M1 was associated with decreased risk of CHDs (aOR = 0.182, 95% CI:0.034, 0.983). No significant correlations were found between 1‐OHPG concentration and methylation levels of NKX2‐5_M1.ConclusionsMaternal PAHs exposure was linked with CHDs. Higher methylation of the upstream sequence of NKX2‐5 promoter decreased the risk of CHDs. There was no correlation between maternal PAHs exposure and the methylation level of NKX2‐5.
Foreign body aspiration in two young infants: The devil in the carpet
Authors: Goussard Pierre , Merven Marc , Parker Noor , Gie Andre , Myburgh Chantelle , Andronikou Savvas , Wagenaar Riegart 
Published: May 2022

AbstractForeign body aspiration is rare in children below 6 months of age. Very young children presenting with stridor, atypical croup presentation, and not responding accordingly, subglottic foreign body aspiration should be considered. These may not always be visible with bedside flexible endoscopy and may need investigation under anesthesia. We report two cases of devil's thorn aspiration in young infants. These children were left on the floor to play and devils thorn may be a danger lurking as the they have been deposited unknowingly by the shoes people wear and pick up by these young infants.
Pipiserpin, a Culex factor Xa inhibitor, affects female reproductive capacity and serves as a potential target for mosquito control
Authors: Zhang Donghui , Zhu Yawen , Lu Qingyu , Chen Fei , Wang Jiahui , Hou Min , Chen Lu , Xu Zhipeng , Ji Minjun , Chen Lin 
Published: May 2022

AbstractBACKGROUNDMosquito control is still the main prevention and control measure for numerous mosquito‐borne diseases causing millions of deaths each year. New strategies for mosquito control are in demand. Proteases play an important role in mosquito physiology, therefore this study explored the inhibition of a serpin (serine protease inhibitor) in mosquitoes and its effect on reproductive capacity.RESULTSA factor Xa inhibitor homolog (named Pipiserpin) was amplified and identified in Culex pipiens pallens mosquitoes. We expressed a recombinant Pipiserpin protein in vitro against which a mouse antiserum was generated. We found that female mosquitoes expressed more Pipiserpin protein than male mosquitoes. After mating, female mosquitoes were fed with blood mixed with different amounts of antisera and results showed that consumption of Pipiserpin impeded ovary development and decreased eggs hatching rates compared to that of the pre‐immune serum group.CONCLUSIONWe identified a Culex mosquito factor Xa inhibitor, Pipiserpin, which affects female reproductive potential. Our results suggest that Pipiserpin may be a novel target for mosquito population control. The conclusions from our study on Cx. pipiens pallens might serve as a reference for the development of control measures for other mosquitoes as well. © 2022 Society of Chemical Industry.
A rare case of pulmonary mucormycosis complicated by hydropneumothorax, successfully treated with non‐surgical therapies
Authors: Liu Qiliang , Good William , Salmon Andrew , Gow Nicholas , Griffiths Paul 
Published: May 2022

AbstractPulmonary mucormycosis (PM) is a rare but rapidly progressive fungal infection associated with high mortality. A review of the literature suggests that pleural effusions and pneumothoraces are uncommon manifestations associated with distant dissemination. Combined surgical interventions and prolonged antifungal therapy constitute the standard first‐line management, with significantly poorer outcomes seen in patients managed with medical therapy alone. Here, we report an unusual case of PM complicated by hydropneumothorax in an immunocompromised patient, in whom comorbidities and disease burden precluded surgical debridement. His disease was ultimately treated with intravenous amphotericin B and maintenance posaconazole after adjunctive drainage. This clinical experience highlights the efficacy of antifungal therapy alone in the treatment of potentially fatal cases of PM unsuitable for surgery.
The knowledge‐incentive tradeoff: Understanding the relationship between research and development decentralization and innovation
Authors: Eklund John C. 
Published: May 2022

AbstractResearch SummaryStrategy scholars view innovation through the lens of knowledge recombination, whereas organizational economics scholars view innovation through the lens of effective incentive design. This sets up a tension regarding how firms should structure their research and development (R&D) units. Namely, decentralization facilitates the effective use of incentives but comes with the cost of reduced intra‐organizational knowledge flows. In this study, I unpack this tension by examining the novelty of inventions that firms create and develop. I argue that R&D centralization facilitates the creation and development of inventions that are more novel, whereas R&D decentralization facilitates the creation of more inventions of lower average novelty and their progression through development. I find support for these arguments in the pharmaceutical industry between 1995 and 2015.Managerial SummaryWhen does the effective use of incentives or a firm's knowledge have a greater impact on a firm's innovation? This has important managerial implications as it shapes whether firms are better off centralizing or decentralizing their R&D units. Centralization enables firms to make better use of their knowledge and decentralization ensures the better use of incentives. More effective use of incentives associated with greater decentralization of R&D is more critical if firms wish to create and develop more inventions that are of lower average novelty. In contrast, more effective use of a firm's knowledge associated with greater centralization of R&D is more critical if firms want to create and develop a lower quantity of inventions that are of greater average novelty.
Ecofriendly high‐performance thin‐layer chromatography‐densitometric method for determination of a new triple pharmaceutical combination targeting Helicobacter pylori eradication along with greenness profile assessment
Authors: Darweish Eman , Eissa Maya S. , Fayez Yasmin M. , Marzouk Hoda M. 
Published: May 2022

AbstractHerein, an ecofriendly, simple, accurate, and cost‐effective high‐performance thin‐layer chromatography‐densitometic method was developed and optimized for separation and estimation of the novel triple therapy combination of Tinidazole, Clarithromycin, and Lansoprazole for treatment of Helicobacter pylori infection. Successful chromatographic separation was established using high‐performance thin‐layer chromatography silica gel 60 F254 plates as stationary phase and a developing system consisted of ethanol‐acetone‐ammonia (10.0:4.0:0.1, by volume). Scanning of the bands was accomplished at 210 nm. The presented method has been fully validated and found to be suitable for application in routine quality control of the studied drugs in their dosage form with average percent recoveries of 99.97 ± 0.62, 100.89 ± 0.51, and 99.78 ± 0.56% for Clarithromycin, Tinidazole and Lansoprazole, respectively. The developed method was assessed with four greenness evaluation tools; National Environmental Method Index, Analytical Eco‐scale, Green Analytical Procedure Index, and Analytical GREEnness Metric tool. The suggested method was demonstrated to be more environmental friendly than the reported high‐performance liquid chromatography one in terms of the use of hazardous chemicals and solvents, energy consumption, and waste generation.