bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are antidepressants really safe and effective in people with epilepsy and depression?
Authors: Makan Dansheela Shari 
Published: August 2022

SUMMARYThis commentary gives a very brief overview of depression in epilepsy (prevalence, risk, associations between the two conditions, antidepressant medication) and assesses the quality and results of a Cochrane Review comparing antidepressants with placebo and psychotherapy in managing the condition. Although antidepressants were not shown to be more effective than other interventions and no link between antidepressants and increased seizure frequency was observed, the low-quality evidence obtained cannot provide conclusive answers.
Nonlinear periodic structures in magnetoplasma with nonthermal electrons and positrons
Authors: Alyousef Haifa A. , Khalid Muhammad , Kabir Abdul 
Published: August 2022

Abstract
In the present study, we address the problem of cnoidal waves (CWs) in magnetized electron-positron-ion (e-p-i) plasma with nonthermal electrons and positrons. The Korteweg-de Vries equation (KdVE) is derived using the reductive perturbation technique (RPT) and its cnoidal wave (CW) solution is analyzed. The impact of relevant plasma parameters on the characteristics of the ion-acoustic (IA) cnoidal structures are discussed in detail. The application of the present investigation is discussed.
Measuring Health-Related Quality of Life in Thyroid Eye Disease
Authors: Sharma Anu , Stan Marius N , Rootman Dan B 
Published: August 2022

Abstract
Health-related quality of life (HQOL) is a concept that aims to understand the totality of an individual’s experience of their disease state. This can include the physical, psychosocial, emotional, and psychological effects of a disease state. A complex and multifactorial concept, HQOL can be challenging to measure accurately and reliably. Thyroid eye disease (TED), as a multifaceted physically debilitating and facial disfiguring disorder, presents unique challenges and opportunities in the measurement of HQOL. Multiple distinct tools have been developed for this purpose, each has been constructed, assessed, and utilized. This discussion surveys the landscape of TED-related QOL measurement and presents challenges for the future. Clinicians and clinical researchers should implement TED-related QOL measurement as part of routine TED care and as a primary outcome in TED clinical trials. We recommend utilizing the Graves’ ophthalmopathy (GO)-QOL routinely in clinical practice and as a primary outcome in TED clinical trials. If the GO-QOL is too time-consuming or in mild TED, a faster alternative is the TED-QOL.
Sex-specific Effects of Endocrine-disrupting Chemicals on Brain Monoamines and Cognitive Behavior
Authors: Hilz Emily N , Gore Andrea C 
Published: August 2022

Abstract
The period of brain sexual differentiation is characterized by the development of hormone-sensitive neural circuits that govern the subsequent presentation of sexually dimorphic behavior in adulthood. Perturbations of hormones by endocrine-disrupting chemicals (EDCs) during this developmental period interfere with an organism’s endocrine function and can disrupt the normative organization of male- or female-typical neural circuitry. This is well characterized for reproductive and social behaviors and their underlying circuitry in the hypothalamus and other limbic regions of the brain; however, cognitive behaviors are also sexually dimorphic, with their underlying neural circuitry potentially vulnerable to EDC exposure during critical periods of brain development. This review provides recent evidence for sex-specific changes to the brain’s monoaminergic systems (dopamine, serotonin, norepinephrine) after developmental EDC exposure and relates these outcomes to sex differences in cognition such as affective, attentional, and learning/memory behaviors.
Prognostic Significance of Baseline Frailty Status in Traumatic Spinal Cord Injury
Authors: Dicpinigaitis Alis J. , Al-Mufti Fawaz , Bempong Phillip O. , Kazim Syed Faraz , Cooper Jared B. , Dominguez Jose F. , Stein Alan , Kalakoti Piyush , Hanft Simon , Pisapia Jared , Kinon Merritt , Gandhi Chirag D. , Schmidt Meic H. , Bowers Christian A. 
Published: August 2022

BACKGROUND:
Literature evaluating frailty in traumatic spinal cord injury (tSCI) is limited.

OBJECTIVE:
To evaluate the prognostic significance of baseline frailty status in tSCI.

METHODS:
Patients with tSCI were identified in the National Inpatient Sample from 2015 to 2018 and stratified according to frailty status, which was quantified using the 11-point modified frailty index (mFI).

RESULTS:
Among 8825 operatively managed patients with tSCI identified (mean age 57.9 years, 27.6% female), 3125 (35.4%) were robust (mFI = 0), 2530 (28.7%) were prefrail (mFI = 1), 1670 (18.9%) were frail (mFI = 2), and 1500 (17.0%) were severely frail (mFI ≥ 3). One thousand four-hundred forty-five patients (16.4%) were routinely discharged (to home), and 320 (3.6%) died during hospitalization, while 2050 (23.3%) developed a severe complication, and 2175 (24.6%) experienced an extended length of stay. After multivariable analysis adjusting for age, illness severity, trauma burden, and other baseline covariates, frailty (by mFI-11) was independently associated with lower likelihood of routine discharge [adjusted odds ratio (aOR) 0.82, 95% CI 0.77-0.87; P < .001] and development of a severe complication (aOR 1.17, 95% CI 1.12-1.23; P < .001), but not with in-hospital mortality or extended length of stay. Subgroup analysis by age demonstrated robust associations of frailty with routine discharge in advanced age groups (aOR 0.71 in patients 60-80 years and aOR 0.69 in those older than 80 years), which was not present in younger age groups.

CONCLUSION:
Frailty is an independent predictor of clinical outcomes after tSCI, especially among patients of advanced age. Our large-scale analysis contributes novel insights into limited existing literature on this topic.
Overwintering in North American domesticated honeybees (Apis mellifera) causes mitochondrial reprogramming while enhancing cellular immunity
Authors: Cormier Simon B. , Léger Adèle , Boudreau Luc H. , Pichaud Nicolas 
Published: August 2022

ABSTRACT
Many factors negatively affect domesticated honeybee (Apis mellifera) health, causing a global decrease in their population year after year with major losses occurring during winter, and the cause remains unknown. Here, we monitored for 12 months North American colonies of honeybees enduring important temperature variations throughout the year, to assess the metabolism and immune system of summer and winter honeybee individuals. Our results show that in flight muscle, mitochondrial respiration via complex I during winter is drastically reduced compared with summer. However, the capacity for succinate and glycerol-3-phosphate (G3P) oxidation by mitochondria is increased during winter, resulting in higher mitochondrial oxygen consumption when complex I substrates, succinate and G3P were assessed altogether. Pyruvate kinase, lactate dehydrogenase, aspartate aminotransferase, citrate synthase and malate dehydrogenase tend to have reduced activity levels in winter, unlike hexokinase, NADH dehydrogenase and pyruvate dehydrogenase. Transcript abundance of highly important immunity proteins such as Vitellogenin and Defensin-1 were also increased in winter bees, and a stronger phagocytic response as well as a better hemocyte viability was observed during winter. Thus, a reorganization of substrate utilization favoring succinate and G3P while negatively affecting complex I of the ETS is occurring during winter. We suggest that this might be due to complex I transitioning to a dormant conformation through post-translational modification. Winter bees also have an increased response for antibacterial elimination. Overall, this study highlights previously unknown cellular mechanisms between summer and winter honeybees that further our knowledge about this important species.
High-Low Promotion Policies for Peak-End Demand Models
Authors: Cohen-Hillel Tamar , Panchamgam Kiran , Perakis Georgia 
Published: August 2022

In-store promotions are a highly effective marketing tool that can have a significant impact on revenue. In this research, we study the question of dynamic promotion planning in the face of Bounded-Memory Peak-End demand models. In order to determine promotion strategies, we establish that a High-Low pricing policy is optimal under diagonal dominance conditions (so that the current period price dominates both past period price effects and competitive product price effects on the demand), as well as conditions on the price dispersion. We show that finding the optimal High-Low dynamic promotion policy is NP-hard in the strong sense. Nevertheless, for the special case of promotion planning for a single item, we propose a compact Dynamic Programming (DP) approach that can find the optimal promotion plan that follows a High-Low policy in polynomial time. When the diagonal dominance conditions do not hold, and, hence, a High-Low policy is not necessarily optimal, we show that the optimal High-Low policy that is found by our proposed DP can find a provably near-optimal solution. Using the proposed DP as a subroutine, for the case of multiple items, we propose a Polynomial-Time-Approximation Scheme (PTAS) that can find a solution that can capture at least [Formula: see text] of the optimal revenue and runs in time that is exponential only in [Formula: see text]. Finally, we test our approach on data from large retailers and demonstrate an average of [Formula: see text] increase in revenue relative to the retailer’s current practices. This paper was accepted by Chung Piaw Teo, optimization. Funding: Financial support from the Oracle Corporation [External Research Office grant] and the National Science Foundation [Grant CMMI-1162034] is gratefully acknowledged.
Apposition compound-eye image scanner by glass plate optics
Authors: Kawano Hiroyuki , Nakagawa Naoki , Takushima Shigeru , Makita Taisuke , Kurihara Kohei , Sugano Miki 
Published: August 2022

We propose a design approach for a thin image scanner using the concept of an apposition compound eye comprising many imaging units that take only one pixel image. Although light shielding between adjacent imaging units is always one of the main issues for an artificial compound eye, a simple plane structure using three aperture array layers on two glued glass plates prevents such stray light. Our prototyped scanner, with only 6.8-mm thickness as a packaged module, has 632 microlenses with 200-dpi resolution, resulting in a field of view of 80 mm. The evaluated images show no ghost images.
Impact evaluation of a brief online training module on physician use of the Maryland, USA, Prescription Drug Monitoring Program
Authors: Adenaiye Oluwasanmi O. , Zirpoli Julia B. , Tan Marissa , Day Brendan F. , Bolaji Olayiwola , Mitchell Clifford S. , Cloeren Marianne 
Published: August 2022

Background
Prescription Drug Monitoring Programs (PDMPs) are electronic databases that track controlled substance prescriptions in a state. They are underused tools in preventing opioid abuse. Most PDMP education research measures changes in knowledge or confidence rather than behavior.

Objective
To evaluate the impact of online case-based training on healthcare provider use of the Maryland (USA) PDMP.

Methods
We used e-mail distribution lists to recruit providers to complete a brief educational module. Using a pre-training and post-training survey in the module, we measured self-reported PDMP use patterns and perceived PDMP value in specific clinical situations and compared pre- and post-training responses. Within the module, we presented three fictional pain cases and asked participants how they would manage each, both before, and then after presenting prescription drug history simulating a PDMP report. We measured changes in the fictional case treatment plans before and after seeing prescription history. Finally, we measured and compared how often each participant accessed the Maryland PDMP database before and after completing the educational module. We used multivariate logistic regression to measure the effect of the intervention on actual PDMP use frequency.

Results
One hundred and fifty participants enrolled and completed the training module, and we successfully retrieved real-world PDMP use data of 137 of them. Participants’ decisions to prescribe opioids changed significantly after reviewing PDMP data in each of the fictional cases provided in the module. In the months following the training, the rate of PDMP use increased by a median of four use-cases per month among providers in practice for less than 20 years (p = 0.039) and two use-cases per month among infrequent opioid prescribers (p = 0.014).

Conclusion
A brief online case-based educational intervention was associated with a significant increase in the rate of PDMP use among infrequent opioid prescribers and those in practice less than 20 years.
How do care home staff use non-pharmacological strategies to manage sleep disturbances in residents with dementia: The SIESTA qualitative study
Authors: Webster Lucy , Costafreda Sergi G. , Powell Kingsley , Livingston Gill 
Published: August 2022

Background
Sleep disturbances affect 38% of care home residents living with dementia. They are often treated with medication, but non-pharmacological interventions may be safer and effective yet more difficult to implement. In the SIESTA study (Sleep problems In dEmentia: interviews with care home STAff) we explored care home staffs’ experience of managing sleep disturbances in their residents living with dementia.

Methods
We conducted one-to-one semi-structured interviews in four UK care homes, and purposively recruited a maximum variation sample of 18 nurses and care assistants, who were each interviewed once. We used a topic guide and audio-recorded the interviews. Two researchers independently analysed themes from transcribed interviews.

Results
Staff used a range of techniques that often worked in improving or preventing residents’ sleep disturbance. During the daytime, staff encouraged residents to eat well, and be physically active and stimulated to limit daytime sleep. In the evening, staff settled residents into dark, quiet, comfortable bedrooms often after a snack. When residents woke at night, they gave them caffeinated tea or food, considered possible pain and discomfort, and reassured residents they were safe. If residents remained unsettled, staff would engage them in activities. They used telecare to monitor night-time risk. Staff found minimising daytime napping difficult, described insufficient staffing at night to attend to reorient and guide awake residents and said residents frequently did not know it was night-time.

Conclusions
Some common techniques, such as caffeinated drinks, may be counterproductive. Future non-pharmacological interventions should consider practical difficulties staff face in managing sleep disturbances, including struggling to limit daytime napping, identifying residents’ night-time needs, day-night disorientation, and insufficient night-time staffing.
Global burden of SARS-CoV-2 infection, hospitalization and case fatality rate among COVID-19 vaccinated individuals and its associated factors: A systematic review and meta-analysis protocol
Authors: Nka Alex Durand , Ka’e Aude Christelle , Bouba Yagai , Ngoufack Jagni Semengue Ezechiel , Tommo Tchouaket Michel Carlos , Takou Désiré , Pabo Willy , Fainguem Nadine , Sosso Samuel Martin , Colizzi Vittorio , Perno Carlo-Federico , Fokam Joseph 
Published: August 2022

Background
COVID-19 has been the most important public health concern worldwide since 2020. Several vaccines are now available to help in controlling COVID-19 associated morbidity and mortality. This study will aim to provide the global and regional prevalence of SARS-CoV-2 infection as well as an estimate of disease severity among COVID-19 vaccinated individuals.

Materials and methods
In order to determine the global burden of SARS-CoV-2 infection among vaccinated individuals, we will systematically extract and review papers from PubMed/MEDLINE, Excerpta Medica database (EMBASE), Cochrane Central Register of Controlled Trials (CENTRAL), Science direct and Cumulative Index to Nursing and Allied Health Literature (CINAHL). All the studies describing the prevalence and/or disease severity (hospitalization and case fatality rate) data of COVID-19 among individuals who received a partial or complete dose of WHO-approved COVID-19 vaccines will be eligible. A random effect model will be used to calculate the pooled prevalence and to estimate the disease severity. Subgroup analysis will be performed to explore the association between the number of vaccine doses received and the COVID-19 burdens.

Discussion
This systematic review and meta-analysis will provide the global estimate data on pooled prevalence, hospitalization and case fatality rates of COVID-19 among vaccinated individuals. Moreover, the factors associated with reinfection and disease severity will be equally investigated in the meta-analysis. The results of this study will contribute in the understanding and estimation of the global burden of COVID-19 among vaccinated individuals. Findings will provide meaningful information for the success of the current global rollout of COVID-19 vaccination strategies and pave the way for future interventions.

Systematic review registration
CRD42021273074.
Comediação: Desafios, Aplicação e Cuidados / Co-mediation: Challenges, Application and Care
Authors: Rosa Beatriz Vidigal Xavier da Silveira , Sardinha Flavia Campos , Pinto Maristela Lins 
Published: August 2022

Resumo: O presente artigo trata da comediação, de sua aplicação na prática da mediação de conflitos, dos cuidados que se deve ter ao utilizá-la e dos desafios a serem enfrentados em alguns contextos que demandam o uso desta técnica, que pode ser bastante efetiva em diversos casos. Este artigo foi escrito considerando as discussões do Grupo de Estudos Laboratório de Mediação e de experiências práticas de suas autoras. Abstract: This article deals with co-mediation, its application in the practice of conflict mediation, the care that must be taken when using it and the challenges to be faced in some contexts that demand the use of this technique, which can be quite effective in many cases. This article was written considering the discussions of the Mediation Laboratory Study Group and the practical experiences of its authors. Keywords: Mediation; Reflection; Complexity.
O Processo Dialógico na Mediação / The Dialogical Process in Mediation
Authors: Parisi Denise Antonia Lentini , Jacchieri Mayra Lucia Araujo 
Published: August 2022

Resumo: O presente artigo tem como objetivo trazer outros saberes que, de forma interdisciplinar, possam contribuir para o processo dialógico da Mediação.Para tanto, promove-se uma breve análise sobre a necessidade de reconhecimento do outro – alteridade -, valendo-se da obra de José Saramago, Ensaios sobre a Cegueira, em conexão com o desafio de iniciar o diálogo nas Mediações. Em seguida, ocupa-se sobre quem fala, o que se fala e de que lugar fala sobre o conflito, a partir dos saberes de Milton Santos, no que tange à identidade territorial, inclusive com foco na vulnerabilidade. Para lançar luz sobre o protagonismo no processo dialógico da Mediação, o conhecimento de Paulo Freire é resgatado. Finalmente, o saber cuidar, de Leonardo Boff, será apresentado como fio condutor de todo o processo dialógico em referência.Palavras-chave: Diálogo; Mediação; Alteridade; Protagonismo; Identidade Territorial. Abstract: This article aims to bring other knowledge that, in an interdisciplinary way, can contribute to the dialogical process of Mediation. José Saramago, Essays on Blindness, in connection with the challenge of initiating dialogue in Mediations. Then, it deals with who speaks, what is spoken and from which place is spoken about the conflict, based on the knowledge of Milton Santos, with regard to territorial identity, including a focus on vulnerability. To shed light on the leading role in the dialogical process of Mediation, Paulo Freire's knowledge is rescued. Finally, knowing how to care, by Leonardo Boff, will be presented as the guiding thread of the entire dialogic process in question.Keywords: Dialogue; Mediation; Alterity; Protagonism; Territorial Identity.
Provenienzforschung in der ZBW: Erkenntnisse über die verdächtigen Zugänge zwischen 1933 und 1949
Authors: Köhler Norman 
Published: August 2022

Zusammenfassung
In einem vom Deutschen Zentrum Kulturgutverluste in Magdeburg geförderten Provenienzforschungsprojekt wurden Zugänge aus der Zeitspanne 1933–1949 in den Standorten der ZBW – Leibniz-Informationszentrum Wirtschaft in Kiel und Hamburg in den Jahren 2018–2021 auf NS-Raubgut untersucht. Neben zahlreichen Bänden, die als verdächtig angesehen werden, sind lediglich zehn Bände als eindeutig belastete Zugänge einzustufen. Die Lieferanten dieser Exemplare sind eine Buchhandlung in Brüssel, die Gestapo, die Staatsbibliothek Posen und das Wehrwirtschaftsamt bzw. wurden sie durch eine Dienstreise des Kieler Bibliotheksdirektors Wilhelm Gülich erworben.
Supercritical CO2 extraction, chemical composition, and antioxidant effects of Coreopsis tinctoria Nutt. oleoresin
Authors: Qiu Yiyi , Ruan Hui 
Published: August 2022

Abstract

Coreopsis tinctoria Nutt. was used to extract oleoresin through supercritical CO2 extraction technology. The extraction conditions were optimized using response surface methodology, and the chemical composition of C. tinctoria Nutt. oleoresin (CTO) was analyzed. Under the optimal conditions, the antioxidant activity of oleoresin was determined using 1,1-diphenyl-2-picrylhydrazyl (DPPH˙) and 2,2′-azino-bis-(3-ethylbenzo-thiazoline-6-sulphonic acid)diammonium salt (ABTS˙+) free radical scavenging assays. The optimal extraction conditions were a 27.5 MPa extraction pressure, a 45°C extraction temperature, and a 3 h extraction time. Under these extraction conditions, oleoresin yield was up to 3.163%. Compared to steam distillation extraction, the CTO extracted using supercritical CO2 had more abundant components. The EC50 of CTO for DPPH˙ and ABTS˙+ free radical scavengers was 1.54 and 1.07 mg/mL, respectively.
Polar foliations on symmetric spaces and mean curvature flow
Authors: Liu Xiaobo , Radeschi Marco 
Published: August 2022

Abstract
In this paper, we study polar foliations on simply connected symmetric spaces with non-negative curvature. We will prove that all such foliations are isoparametric as defined in [E. Heintze, X. Liu and C. Olmos,
Isoparametric submanifolds and a Chevalley-type restriction theorem,
Integrable systems, geometry, and topology,
American Mathematical Society, Providence 2006, 151–190]. We will also prove a splitting theorem which, when leaves are compact, reduces the study of such foliations to polar foliations in compact simply connected symmetric spaces. Moreover, we will show that solutions to mean curvature flow of regular leaves in such foliations are always ancient solutions. This generalizes part of the results in [X. Liu and C.-L. Terng,
Ancient solutions to mean curvature flow for isoparametric submanifolds,
Math. Ann. 378 2020, 1–2, 289–315] for mean curvature flows of isoparametric submanifolds in spheres.
Derivations of Murray–von Neumann algebras
Authors: Ber Aleksey , Kudaybergenov Karimbergen , Sukochev Fedor 
Published: August 2022

AbstractIn this paper, we answer in the affirmative the long-standing conjecture that the first cohomology group of the Murray–von Neumann algebraS⁢(ℳ){S(\mathcal{M})}of all operators affiliated with a typeII1{\mathrm{II}_{1}}von Neumann algebraℳ{\mathcal{M}}is 0. That is, we show that all derivations ofS⁢(ℳ){S(\mathcal{M})}are inner.