bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy of a tart cherry drink for the treatment of patellofemoral pain in recreationally active individuals: a placebo randomized control trial
Authors: Sinclair Jonathan , Stainton Philip , Dillon Stephanie , Taylor Paul John , Richardson Cassandra , Bottoms Lindsay , Hobbs Sarah Jane , Shadwell Gareth , Liles Naomi , Allan Robert 
Published: June 2022

Abstract
Purpose
This study aimed to explore the efficacy of U.S. Montmorency tart cherry in treating recreationally active individuals with patellofemoral pain.

Methods
Twenty-four recreationally active participants with patellofemoral pain were randomly separated into either placebo (males N = 8, females N = 4, age = 43.30 ± 7.86 yrs, mass = 72.10 ± 17.89 kg, stature = 171.16 ± 10.17, BMI = 24.31 ± 3.75 kg/m2, symptom duration = 30.18 ± 10.90) or Montmorency tart cherry (males N = 9, females N = 3, age = 41.75 ± 7.52 yrs, mass = 76.96 ± 16.64 kg, stature = 173.05 ± 7.63, BMI = 25.53 ± 4.03 kg/m2, symptom duration = 29.73 ± 11.88) groups. Both groups ingested 60 mL of either Montmorency tart cherry concentrate or taste matched placebo daily for 6 weeks. Measures of self-reported pain (KOOS-PF), psychological wellbeing (COOP WONCA), and sleep quality (PSQI) alongside blood biomarkers (C-reactive protein, uric acid, TNF alpha, creatinine, and total antioxidant capacity) and knee biomechanics were quantified at baseline and 6 weeks. Differences between groups were examined using linear mixed-effects models.

Results
There was 1 withdrawal in the cherry and 0 in the placebo group and no adverse events were noted in either condition. The placebo condition exhibited significant improvements (baseline = 67.90 ± 16.18 & 6 weeks = 78.04 ± 14.83) in KOOS-PF scores compared to the tart cherry group (baseline = 67.28 ± 12.55& 6 weeks = 67.55 ± 20.61). No other statistically significant observations were observed.

Conclusion
Tart cherry supplementation as specifically ingested in the current investigation does not appear to be effective in mediating improvements in patellofemoral pain symptoms in recreationally active individuals.
Life cycle stage practices and strategies for circular economy: assessment in construction and demolition industry of an emerging economy
Authors: Asante Richard , Faibil Daniel , Agyemang Martin , Khan Sharffudin Ahmed 
Published: June 2022

AbstractThe strategic implementation of circular economy (CE) practices in the construction and demolition (C&D) industry is critical for achieving environmental sustainability goals. Understanding CE practices based on reduce, reuse, recycle, recover, remanufacture, and redesign (6R) principles from the perspective of the whole life cycle can promote the implementation of CE practices in the C&D industry. However, studies that shed light on this subject especially in emerging economies are generally lacking. This study contributes to filling this gap by using a three-phase methodology consisting of a literature review and a hybrid best–worst method and grey relational analysis to give insights into practices and strategies to prioritize CE practice implementation. Specifically, the paper focuses on identifying CE practices based on 6R principles, the significance of the identified CE practices, and understanding how to prioritize the implementation of the significant CE practices. The study’s findings established that implementing CE practices based on reduce and recover principles at the design stage contributes significantly to environmental sustainability. Additionally, the study highlights the relevance of both bottom-up and top-down approaches in the implementation of CE practices.
Understanding the Intergenerational Transmission of Criminal Justice Involvement: a Multi-birth-Cohort Study in Singapore
Authors: Ting Ming Hwa , Xu Xuexin , Chu Chi Meng , Lai Pierce , Li Dongdong 
Published: June 2022

AbstractThis study aimed to ascertain the impact of parent’s criminal justice involvement on offspring’s contact with the criminal justice system in Singapore. It further analyzed how various aspects of parent’s criminal justice involvement influence the extent of the intergenerational transmission. Linked administrative data of five full birth cohorts (1965, 1970, 1975, 1980, 1985;N = 93,829) and their children were analyzed (Nchildren = 183,015). Restricted mean survival time (RMST) analyses were conducted, and results suggested that children whose parent had contact with the criminal justice system had fewer crime-free years compared to children whose parent did not have any criminal justice contact. In addition, the impact of paternal and maternal involvement with the criminal justice system was greater on daughters than sons; the impact of custodial sentences was greater than that of noncustodial sentences; and it was also found that a higher frequency of parent’s criminal justice involvement increased the likelihood of children’s contact with the criminal justice system. Intergenerational transmission of criminal justice involvement was observed in Singapore, and so the findings highlighted the importance of supporting families of offenders to disrupt the negative cycle of offending behavior.
Assessing Alcohol Expectations in University Students: the APNE Scale
Authors: Gomà-i-Freixanet Montserrat , Ferrero-Rincón Gabriela , Granero Roser 
Published: June 2022

Abstract
The increasing prevalence of alcohol consumption at early ages has led to major efforts to identify alcohol drinking habits within this highly vulnerable group, and individuals with hazardous patterns of alcohol consumption. The aim of this study was to examine the psychometric properties of the Alcohol Positive and Negative Expectations Scale (APNE; a new screening tool developed to identify expectations toward alcohol), and to examine the patterns of alcohol drinking in young adults. The sample included n = 1309 participants (college students) with age range 20 to 25 years. Confirmatory factor analysis (CFA) performed through Generalized Structural Equation Models (GSEM) verified the structure of the APNE, correlational models evaluated convergent-discriminant validity, and logistic regression assessed the discriminative ability to identify harmful drinking. The bifactor structure for the APNE was confirmed (positive and negative expectations toward alcohol drinking), with adequate goodness-of-fit (RMSEA = 0.052, CFI = 0.936, TLI = 0.914, and SRMR = 0.075). Multi-group modeling showed invariance by sex (p = .543) and age (p = .395) for the measurement coefficients. High correlations with external measures of alcohol use/abuse and discriminant capacity to identify harmful drinking were obtained. Compared to men, women reported higher mean scores in the negative expectations factor (p = .003). Polynomial linear trends showed that the likelihood of positive expectations toward alcohol decreased with age, while negative expectations increased. The APNE is a brief, reliable, valid, and accurate tool to assess positive and negative expectations toward alcohol consumption in college students. Tools like the APNE can support policymakers to make informed decisions about the implementation of prevention and treatment programs targeted at this segment of the population, the development of personalized alcohol programs, and the reappraisal of public campaigns.
Locked in and locked out: sequelae of a pandemic for distressed and vulnerable teenagers in Ireland
Authors: McLoughlin Aoibheann , Abdalla Ahad , Gonzalez Jade , Freyne Aoife , Asghar Muhammad , Ferguson Yolande 
Published: June 2022

Abstract
Objective
The aim of this study is to investigate the impact of the coronavirus pandemic on teenage psychiatry referrals following crisis presentation to the adult emergency department (ED) of an Irish tertiary hospital. In doing so, this study will specifically examine the effect of COVID-19 on self-injurious behaviour, suicidality and substance use among older adolescents (age 16/17 years).

Methods
This is a retrospective descriptive analysis of acute adolescent psychiatry referrals assessed out-of-hours via the adult ED psychiatry service across three consecutive time points (during the months of March, April and May) from pre-pandemic, 2019 (T1); initial pandemic, 2020 (T2); and peak pandemic, 2021 (T3). Data were obtained via the hospital’s ED-specific electronic database, review of original assessment notes and cross-referenced by manually extracting data logged in the on-call register.

Results
Crisis psychiatry assessments of teenagers during on-call hours trebled during the period of this study (p < 0.001). Although ED/crisis referrals initially decreased overall at the start of the pandemic, the rate of teenage referrals remained constant, before increasing as restrictions tightened in lockdown. The negative impact of COVID-19 on teenagers’ ability to cope was found to be statistically significant (p = 0.001). Changes in rates of self-harming and/or suicidal behaviours were not statistically significant between 2019, 2020 and 2021 (p = 0.082). Alcohol misuse occurred in up to one-third of cases across each timeframe and remained virtually constant throughout the pandemic. Drug misuse decreased from onset of COVID-19 (p = 0.01).

Conclusions
To our knowledge, this is the first study to specifically examine the impact of COVID-19 on suicidality, self-harming behaviours, substance misuse and on-call ED presentations of teenagers in Ireland. This study demonstrates that coronavirus-related stress is associated with negative mental health sequelae for vulnerable at-risk older adolescents, as evidenced by a rise in ED presentations and on-call referrals since the onset of the pandemic. Presentation of increased numbers of under-18’s for psychiatry assessment at the adult ED/general hospital indicates a deepening chasm between available and aspirational emergency (adolescent-specific) psychiatric care in the community. Mobilising resilience factors and maximising coping skills for at-risk youth will inform tailored intervention and support strategies along with adequate resourcing of services for vulnerable adolescents in the community.
Updates on Sexually Transmitted Urethro-cystitis
Authors: Mostafa Mostafa M. , Mahdy Ayman , Ghoniem Gamal 
Published: June 2022

Abstract
Purpose of Review
We performed recent literature review with the aim to address the updates in diagnosis and management of sexually transmitted urethro-cystitis.

Recent Findings
There are multiple, recently published studies that collectively lead to an organized stepwise plan for diagnosis and management of sexually transmitted urethro-cystitis.

Summary
Sexually transmitted urethro-cystitis is a common health condition that can be managed efficiently if the appropriate steps are taken in diagnosis and management.
Soluble PD-L1 in blood correlates positively with neutrophil and negatively with lymphocyte mRNA markers and implies adverse sepsis outcome
Authors: Derigs Marcus , Heers Hendrik , Lingelbach Susanne , Hofmann Rainer , Hänze Jörg 
Published: June 2022

AbstractSepsis causes a myriad of immunological reactions that result in life-threatening alterations in the human body. Immunosuppression in sepsis is partly attributed to the programmed death receptor (PD-1) and its associated ligand (PD-L1) via the regulation of lymphocytes and neutrophils. Although the soluble forms of these proteins (i.e., sPD-1 and sPD-L1, respectively) are recognized as possible sepsis biomarkers, their functional implications are yet to be elucidated. Our research assessed the correlation between sPD-1 and sPD-L1 and blood mRNA markers and sepsis outcome. Blood samples of septic patients of urogenital origin versus control patients (both groups: n = 18) were analyzed. Blood serum sPD-1 and sPD-L1 levels were determined using the enzyme-linked immunosorbent assay (ELISA). The whole blood mRNA concentrations of PD-1, PD-L1, neutrophil markers (CEACAM8 and MPO), and T-lymphocyte markers (TCRβ, CD4 and CD8) were determined via reverse transcriptase quantitative PCR (RT-qPCR). sPD-L1 levels were significantly increased in septic patients when compared to the controls, whereas sPD-1 levels were unaltered. Patients with high sPD-L1 levels, as dichotomized to the median, had a significantly shorter survival rate than those with low sPD-L1 levels. The sensitivity/specificity characteristics of sPD-L1 proved significant for sepsis detection. Furthermore, sPD-L1 correlated with the mRNA concentrations of PD-L1, CEACAM, and MPO, as well as major inflammatory markers (C-reactive protein and procalcitonin). However, sPD-L1 negatively correlated with TCRβ, CD4, and CD8 mRNAs. sPD-L1 was found to be significantly increased in septic patients. Notably, sPD-L1 correlated with PD-L1 mRNA and neutrophil markers and was indicative of adverse outcomes.
Cultural psychology of education: approaches and strategies
Authors: Marsico Giuseppina , Dazzani Maria Virginia Machado 
Published: June 2022

AbstractEducation is a human activity that is continuously developing. This is the core of the Cultural Psychology of Education framework. There are no ready-made, perpetual solutions that work everywhere and for every person. Two central themes dominate this chapter: (1) Education is cultural in nature, and (2) Educational Psychology is culturally guided. The Cultural Psychology approach to education reflects the interdisciplinary nature of Educational Psychology and informs its application in a variety of cultural contexts. Cultural Psychology of Education is international and global, promoting cultural sensitivity within the educational environment and the idea that in any society, the application of knowledge in the area of education is locally based. Nevertheless, the field strives to contribute to the discussion about education on a global scale. Cultural Psychology of Education has a necessary moral commitment to the dignity, integrity and diversity of human life. The promotion and protection of the well-being of individuals and diverse human communities is a core aspect inherent in both the theoretical applications and the professional practices.
Alarmerend beeld onder personeel ggz; uitputting, angst- en somberheidsklachten met mogelijk vertrek uit de ggz als gevolg
Authors: van den Broek Anneloes , van Dam Arno , Bongers Inge , Stikkelbroek Yvonne , Bachrach Nathan , de Vroege Lars 
Published: June 2022

SamenvattingNu de COVID-19-pandemie steeds meer geïntegreerd raakt in het dagelijks leven en het aantal ziekenhuisopnamen afneemt, krijgen we meer zicht op de mentale gevolgen van de pandemie voor zorgprofessionals in de geestelijke gezondheidszorg (ggz). Van de ondervraagde ggz-medewerkers (N = 1.372) ervaart 50% meer stressgerelateerde klachten en vertoont 30% somberheidsklachten. Tegelijkertijd melden zich meer cliënten met klachten als direct en indirect gevolg van de COVID-19-pandemie bij de ggz. Dit zorgt voor extra werkdruk in een sector waar de wachtlijsten toch al lang waren. Om uitval en/of vertrek van zorgprofessionals uit de ggz te voorkomen is het nodig om te leren omgaan met de consequenties van de pandemie in de spreekkamer en om met preventiemaatregelen stress/burn-out te voorkomen.
Comparison between hospital- and community-acquired septic shock in children: a single-center retrospective cohort study
Authors: Su Guo-Yun , Fan Chao-Nan , Fang Bo-Liang , Xie Zheng-De , Qian Su-Yun 
Published: June 2022

Abstract
Background
We explored the differences in baseline characteristics, pathogens, complications, outcomes, and risk factors between children with hospital-acquired septic shock (HASS) and community-acquired septic shock (CASS) in the pediatric intensive care unit (PICU).

Methods
This retrospective study enrolled children with septic shock at the PICU of Beijing Children’s Hospital from January 1, 2016, to December 31, 2019. The patients were followed up until 28 days after shock or death and were divided into the HASS and CASS group. Logistic regression analysis was used to identify risk factors for mortality.

Results
A total of 298 children were enrolled. Among them, 65.9% (n = 91) of HASS patients had hematologic/oncologic diseases, mainly with Gram-negative bacterial bloodstream infections (47.3%). Additionally, 67.7% (n = 207) of CASS patients had no obvious underlying disease, and most experienced Gram-positive bacterial infections (30.9%) of the respiratory or central nervous system. The 28-day mortality was 62.6% and 32.7% in the HASS and CASS groups, respectively (P < 0.001). Platelet [odds ratio (OR) = 0.996, 95% confidence interval (CI) = 0.992–1.000, P = 0.028], positive pathogen detection (OR = 3.557, 95% CI = 1.307–9.684, P = 0.013), and multiple organ dysfunction syndrome (OR = 10.953, 95% CI = 1.974–60.775, P = 0.006) were risk factors for 28-day mortality in HASS patients. Lactate (OR = 1.104, 95% CI = 1.022–1.192, P = 0.012) and mechanical ventilation (OR = 8.114, 95% CI = 1.806–36.465, P = 0.006) were risk factors for 28-day mortality in patients with CASS.

Conclusions
The underlying diseases, pathogens, complications, prognosis, and mortality rates varied widely between the HASS and CASS groups. The predictors of 28-day mortality were different between HASS and CASS pediatric patients with septic shock.
Efficiency of ectopic thymectomy by three surgical approaches in non-thymomatous myasthenia gravis
Authors: Zhang Shuishen , Chen Zhenguang , Li Bin , Su Chunhua , Zhu Haoshuai , Zhong Beilong , Zou Jianyong 
Published: June 2022

AbstractBackgroundTo explore the efficiency of ectopic thymectomy by the three surgical approaches of trans-sternum, right unilateral thoracoscopy and thoracoscopic subxiphoid in patients with non-thymomatous myasthenia gravis.Methods155 consecutive non-thymomatous myasthenia gravis patients who underwent extended thymectomy by 3 approaches including trans-sternum, right unilateral thoracoscopy and thoracoscopic subxiphoid in 1st affiliated hospital of Sun Yat-Sen University from January 2017 to October 2019 were reviewed. Differences of perioperative clinical characteristics in three surgical approaches were analyzed.ResultsTime to onset of myasthenia gravis (early or late) (p = 0.018), blood loss (p < 0.001), duration of operation (p = 0.031), duration and volume of thoracic drainage (p = 0.039 andp = 0.026), length of hospitalization (p = 0.039), the efficiency of ectopic thymectomy (p = 0.037), and the detection rate of ectopic thymus in the second quadrant (p = 0.018) were different among the three surgical approaches. In univariate logistic regression analysis, higher efficiency of ectopic thymectomy were associated with transsternal (OR 2.36, 95% CI 1.32–4.22,p = 0.011) and thoracoscopic subxiphoid approaches (OR 2.07, 95% CI 1.12–3.82,p = 0.033). In the multiple logistic regression analysis, the transsternal approach (OR 2.02, 95% CI 1.10–3.71,p = 0.024) was an independent protective factor for the efficiency of ectopic thymectomy.ConclusionsBoth the right unilateral thoracoscopic and thoracoscopic subxiphoid approaches have advantages over the transsternal approach in short-term postoperative recovery. Transsternal approach is still the best choice for ectopic thymectomy while thoracoscopic subxiphoid approach show the potential as an alternative way.
Self-driving Cars and the Right to Drive
Authors: Ratoff William 
Published: June 2022

AbstractEvery year, 1.35 million people are killed on roads worldwide and even more people are injured. Emerging self-driving car technology promises to cut this statistic down to a fraction of the current rate. On the face of it, this consideration alone constitutes a strong reason to legally require — once self-driving car technology is widely available and affordable — that all vehicles on public roads be self-driving. Here I critically investigate the question of whether self-driving, or autonomous, vehicles should be legally mandated. I develop an argument — premised upon Mill’s Harm Principle — that any legislation mandating the use of self-driving vehicles on public roads is morally impermissible. The Harm Principle, under its most plausible interpretation, has it that the state is warranted in legislating against some activity only if that activity violates the rights of others. In brief, I argue that a human driver, who opts to drive herself on public roads rather than rely on self-driving technology, does not violate anyone’s rights when she so acts. Consequently, when granting the Harm Principle, it follows that the state is not warranted in mandating the use of self-driving vehicles on public roads. If I am correct, the proponent of a self-driving vehicle mandate must reject the Harm Principle. Given its intuitive plausibility and central place in liberal philosophical thought, this is a weighty cost.
Methoxyfenozide has minimal effects on replacement queens but may negatively affect sperm storage
Authors: Carroll Mark J. , Corby-Harris Vanessa , Brown Nicholas , Snyder Lucy , Reitz Dylan C. 
Published: June 2022

AbstractHoney bees are incidentally exposed to pesticides such as the insect growth regulator methoxyfenozide (MEOF) during crop pollination, exposures that extend into the hive via contaminated stored food. We examined the sublethal effects of MEOF-contaminated pollen and queen cell wax on replacement queen development. MEOF-exposed colonies were largely able to produce replacement queens of similar physiological and reproductive quality as unexposed colonies. Newly established queens did not differ in their body mass, ovariole development, or protein and fatty acid contents in their ovaries and fat bodies. MEOF and control queens had similar glandular contents of queen mandibular pheromone (QMP) and queen retinue pheromone (QRP) compounds. However, MEOF queens stored less sperm in their spermathecae than control queens. Given that queen productivity is ultimately limited by sperm availability, MEOF contamination might shorten the functional lifespan of exposed queens.
Identification of Age-Associated Proteins and Functional Alterations in Human Retinal Pigment Epithelium
Authors: Jin Xiuxiu , Liu Jingyang , Wang Weiping , Li Jiangfeng , Liu Guangming , Qiu Ruiqi , Yang Mingzhu , Liu Meng , Yang Lin , Du Xiaofeng , Lei Bo 
Published: June 2022

Abstract
Retinal pigment epithelium (RPE) has essential functions, such as nourishing and supporting the neural retina, and is of vital importance in the pathogenesis of age-related retinal degeneration. However, the exact molecular changes of RPE during aging remain poorly understood. Here, we isolated human primary RPE (hRPE) cells from 18 eye donors distributed over a wide age range (10–67 years old). A quantitative proteomic analysis was performed to analyze changes in their intracellular and secreted proteins. Age-group related subtypes and age-associated proteins were revealed and potential age-associated mechanisms were validated in ARPE-19 and hRPE cells. The results of proteomic data analysis and verifications suggest that RNF123- and RNF149-related protein ubiquitination plays an important role in protecting hRPE cells from oxidative damage during aging. In older hRPE cells, apoptotic signaling-related pathways were up-regulated, and endoplasmic reticulum organization was down-regulated both in the intracellular and secreted proteomes. Our work paints a detailed molecular picture of hRPE cells during the aging process and provides new insights into the molecular characteristics of RPE during aging and under other related clinical retinal conditions.