bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances of cancer-associated fibroblasts in liver cancer
Authors: Peng Hao , Zhu Erwei , Zhang Yewei 
Published: August 2022

AbstractLiver cancer is one of the most common malignant tumors worldwide, it is ranked sixth in incidence and fourth in mortality. According to the distinct origin of malignant tumor cells, liver cancer is mainly divided into hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Since most cases are diagnosed at an advanced stage, the prognosis of liver cancer is poor. Tumor growth depends on the dynamic interaction of various cellular components in the tumor microenvironment (TME). As the most abundant components of tumor stroma, cancer-associated fibroblasts (CAFs) have been involved in the progression of liver cancer. The interplay between CAFs and tumor cells, immune cells, or vascular endothelial cells in the TME through direct cell-to-cell contact or indirect paracrine interaction, affects the initiation and development of tumors. Additionally, CAFs are not a homogeneous cell population in liver cancer. Recently, single-cell sequencing technology has been used to help better understand the diversity of CAFs in liver cancer. In this review, we mainly update the knowledge of CAFs both in HCC and CCA, including their cell origins, chemoresistance, tumor stemness induction, tumor immune microenvironment formation, and the role of tumor cells on CAFs. Understanding the context-dependent role of different CAFs subsets provides new strategies for precise liver cancer treatment.
Counting the cost of public and philanthropic R&D funding: the case of olaparib
Authors: Schmidt L. , Sehic O. , Wild C. 
Published: August 2022

Abstract
Background
Lack of transparency around manufacturing costs, who bears the bulk of research and development costs and how total costs relate to the pricing of products, continue to fuel debates. This paper considers the case of olaparib (Lynparza®), recently indicated for use among BRCA-mutant breast cancer patients, and estimates the extent of public and philanthropic R&D funding.

Methods
We know from previous work that attempting to ascertain the amount of public and philanthropic funding using purely bibliographic sources (i.e., authors’ declarations of funding sources and amounts traced through funders) is limited. Since we knew that a publically funded research unit was pivotal in developing olaparib, we decided to supplement bibliographic data with a Freedom of Information request for administrative records on research funding data from this research centre.

Research
In terms of stages of product development, work conducted in the pre-clinical research stage was the most likely to report non-industry funding (> 90% of pre-clinical projects received public or philanthropic funding). Clinical trials were least likely to be funded through non-industry sources—although even here, contrary to the popular assertion that this is wholly industry-financed, we found public or philanthropic funding declared by 23% of clinical trials. Using information reported in the publications, we identified approximately £128 million of public and philanthropic funding that may have contributed to the development of olaparib. However, this amount was less than one-third of the total amount received by one research institute playing a pivotal role in product discovery. The Institute of Cancer Research reported receiving 38 funding awards to support olaparib work for BRCA-mutant breast cancer totalling over £400 million.

Conclusions
Government or charitable funding of pharmaceutical product development is difficult to trace using publicly available sources, due to incomplete information provided by authors and/or a lack of consistency in funding information made available by funders. This study has shown that a Freedom of Information request, in countries where such requests are supported, can provide information to help build the picture of financial support. In the example of olaparib, the funding amounts directly reported considerably exceeded amounts that could be ascertained using publically available bibliographic sources.
How does a data strategy enable customer value? The case of FinTechs and traditional banks under the open finance framework
Authors: Grassi Laura , Figini Nicolas , Fedeli Lorenzo 
Published: August 2022

AbstractThe coupling of data and digital innovation opens the way for new business in the financial services sector, where customers are placed at the centre of decisions and data can help to develop customer knowledge. To carry out our research, we adopted a multi-case study approach to explore how a data strategy is developed in the retail banking industry, together with its relationship with customer value, paying particular attention to the heterogeneity between traditional banks and financial technology companies (FinTechs). Two main points emerged from the study. Firstly, there are three possible approaches to Open Finance, which are mainly defined by their different corporate cultures, organisational configurations, technological architecture and data value. Secondly, it is not enough to be a FinTech to be best placed to exploit the market, as some traditional banks share the FinTechs’ approach to Open Finance. Designing new tailored products, customising their prices and offering them over the right channels through targeted communication are all data-driven initiatives that stem from cross- or up-selling potential, core to the retail banking industry for turning a customer into a cash flow, thus enabling value to be created for customers. Our findings additionally revealed that there is a form of external information asymmetry between the customer and the bank, and that there is also an internal asymmetry between bank departments, as their visibility on information about the same customer may differ.
iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells
Authors: Sieber Boris , Lu Fangfang , Stribbling Stephen M. , Grieve Adam G. , Ryan Anderson J. , Freeman Matthew 
Published: August 2022

ABSTRACT
Dysregulation of the ERBB/EGFR signalling pathway causes multiple types of cancer. Accordingly, ADAM17, the primary shedding enzyme that releases and activates ERBB ligands, is tightly regulated. It has recently become clear that iRhom proteins, inactive members of the rhomboid-like superfamily, are regulatory cofactors for ADAM17. Here, we show that oncogenic KRAS mutants target the cytoplasmic domain of iRhom2 (also known as RHBDF2) to induce ADAM17-dependent shedding and the release of ERBB ligands. Activation of ERK1/2 by oncogenic KRAS induces the phosphorylation of iRhom2, recruitment of the phospho-binding 14-3-3 proteins, and consequent ADAM17-dependent shedding of ERBB ligands. In addition, cancer-associated mutations in iRhom2 act as sensitisers in this pathway by further increasing KRAS-induced shedding of ERBB ligands. This mechanism is conserved in lung cancer cells, where iRhom activity is required for tumour xenograft growth. In this context, the activity of oncogenic KRAS is modulated by the iRhom2-dependent release of ERBB ligands, thus placing the cytoplasmic domain of iRhom2 as a central component of a positive feedback loop in lung cancer cells.
This article has an associated First Person interview with the first authors of the paper.
Overdose symptoms and positive affect in never-established smokers are moderated by nicotine patch type: A between-subjects experimental investigation
Authors: Gilbert David G. , Stone Bryant M. , Rabinovich Norka E. 
Published: August 2022

Background: A growing number of studies have assessed the effects of acute nicotine on affect, cognition, and brain activity in never-established smokers in attempts to identify mechanisms by which nicotine promotes progression to dependence. However, these acute administration studies have not adequately addressed the problem of potential adverse side effects due to lack of tolerance, such as nausea, feelings of sickness, lightheadedness, and general negative affect and malaise – a term referred to as nicotine overdose events (NODEs). Thus, we report the first study to carefully characterize the prevalence, intensity, and effects of NODEs in never-established-smokers after acute nicotine administration. Methods: We compared the subjective effects of two different 7 mg nicotine patches that have different pharmacokinetics on never-established smokers (n = 67). One patch produces gradual increases in blood nicotine and the other produces more rapid increases in blood nicotine. Results: The findings suggest that in never-smokers, the lowest dose (7 mg) of rapid blood nicotine-rise patches are associated with a high prevalence of NODEs (45.83%) and decreased positive affect (PA) (54.17%) compared to a placebo patch (8.34% for NODEs and 33.34% for PA). The slow-rise patch did not significantly affect nicotine overdose symptoms or PA. Conclusions: Fast blood-rise nicotine patches may not be an ecologically valid method of nicotine delivery to never-smokers, while slow-rise nicotine patches, lower dose, and self-paced dosing may be more appropriate in this population. Findings also highlight the importance of the careful assessment of NODES in this population.
Intra-Canopy Sensing Using Multi-Rotor sUAS: A New Approach for Crop Stress Detection and Diagnosis
Authors: Wiegman Christopher R. , Venkatesh Ramarao , Shearer Scott A. 
Published: August 2022

HighlightsA novel platform was developed for intra-canopy insertion of sensors from a multi-rotor sUAS.The system enables real-time data acquisition from inside the crop canopy comparable to an in-person view.The system provides ideal data for use in modern CNN-based stress diagnosis in row crop production.Abstract. Remote sensing is a critical tool in precision agriculture, giving producers the ability to monitor field conditions throughout the growing season. Although several remote sensing platforms are in use today, small unmanned aerial systems (sUAS) provide the greatest flexibility with the highest resolution. As sUAS capabilities continue to increase (i.e., payload, flight time, and speed), their potential in commercial row crop production is substantial. However, like other forms of remote sensing, traditional sUAS are limited to a nadir view of the target and only capture the top of the crop canopy. Although disease epidemiology and stress origins vary, this limited view usually does not capture the impact of stress at the initial manifestation. For example, stresses such as macronutrient deficiencies in corn originate at the base of the plant and then move upward as nutrients translocate. By the time the stress is detectable at the top of the canopy, the opportunity to mitigate yield loss is limited. A new sUAS platform is needed for sensing beneath the upper portion of the canopy. The Stinger platform, developed to meet this need, consists of a 4.0 m fiberglass rod, custom sensor mount, communication network, and radio link. Using this platform, a variety of sensors can be inserted into the crop canopy from a hovering sUAS. The Stinger platform, when combined with artificial intelligence (AI), significantly expands the capabilities of sUAS for diagnosis of crop stress in row crop production. Keywords: Intra-canopy sensing, Remote sensing, RGB imagery, Stress diagnosis, sUAS.
Ultrahigh frame rate digital light projector using chip-scale LED-on-CMOS technology
Authors: Bani Hassan Navid , Dehkhoda Fahimeh , Xie Enyuan , Herrnsdorf Johannes , Strain Michael J. , Henderson Robert , Dawson Martin D. 
Published: August 2022

Digital light projector systems are crucial components in applications, including computational imaging, fluorescence microscopy, and highly parallel data communications. Current technology based on digital micromirror displays are limited to absolute frame rates in the few tens of kiloframes per second and require the use of external light sources and coupling optics. Furthermore, to realize gray-scale pixel values using duty cycle control, frame rates are reduced proportionally to the number of gray levels required. Here we present a self-emissive chip-scale projector system based on micro-LED pixels directly bonded to a smart pixel CMOS drive chip. The

128
×
128

pixel array can project binary patterns at up to 0.5 Mfps and toggle between two stored frames at megahertz rates. The projector has a 5-bit gray-scale resolution that can be updated at up to 83 kfps, and can be held in memory as a constant bias for the binary pattern projection. Additionally, the projector can be operated in a pulsed mode, with individual pixels emitting pulses down to a few nanoseconds in duration. Again, this mode can be used in conjunction with the high-speed spatial pattern projection. As a demonstration of the data throughput achievable with this system, we present an optical camera communications application, exhibiting data rates of

>
5

Gb
/
s

.
Taming quantum dots’ nucleation and growth enables stable and efficient blue-light-emitting devices
Authors: Ma Zhiwei , Hu Junxia , Tang Liping , Lyu Bingbing 
Published: August 2022

Controlling quantum dots’ emission, nanostructure, and energy level alignment to achieve stable and efficient blue emission is of great significance for electroluminescence devices but remains a challenge. Here, a series of blue ZnCdSeS/ZnS quantum dots was optimized in preparation by taming their nucleation and growth kinetics. Controlling anion precursor reactive properties to modulate quantum dots’ nucleation and growth tailors their alloy core and continuous gradient energy band nanostructure. These results not only elevate the thermal stability of blue quantum dots but also further enhance the injection/transportation of carriers and improve the radiative recombination efficiency in the device. The blue ZnCdSeS/ZnS quantum dots applied in light-emitting devices show superior performance, including maximum current efficiency and external quantum efficiency of, respectively, 8.2 cd/A and 15.8% for blue, 2.6 cd/A and 10.0% for blue-violet, and 10.9 cd/A and 13.4% for sky-blue devices. The blue and sky-blue devices exhibit lifetimes of more than 10,000 h. The proposed methodology for tailoring quantum dots is expected to pave new guidelines for further facilitating visible optoelectronic device exploration.
A study of the precipitation of cerium oxide synthesized from rare earth sources used as the catalyst for biodiesel production
Authors: Hasakul Teerapat , Piticharoenphun Sunthon , Rattanaphra Dussadee , Nuchdang Sasikarn , Kingkam Wilasinee 
Published: August 2022

Abstract
This work aimed to study the preparation of cerium oxide (CeO2) used as the catalyst for biodiesel production from palm oil. The precipitation method was used in the catalyst synthesis. The effects of oxalic concentrations and stirring rates in the precipitation process were investigated. Oxalic acid was added into cerium (Ce) in ethylenediaminetetraacetic acid solution to form Ce oxalate before the Ce oxalate was calcined to obtain CeO2. The results showed that oxalic concentrations and stirring rates slightly affect the morphology of CeO2. However, these parameters considerably affect the amount of basic sites of CeO2. The basicity of CeO2 plays the main role in catalyzing the transesterification reaction for biodiesel production. When CeO2 was used as the catalyst in biodiesel production from palm oil under operating conditions using a 5% catalyst, methanol-to-oil molar ratio of 30:1, reaction temperature of 150°C, 13.8 bars, and 3-h reaction time, CeO2 obtained from 3% oxalic concentration and 400 rpm stirring rates in the precipitation process provided the highest %FAME in the range of 93.9–94.2% since it had higher basicity. In addition, the decrease in surface area of CeO2 after the use was less severe than that of basicity due to catalyst deactivation.
Features of the fluoride behavior in the snow cover under the action of technological and weather conditions
Authors: Ianchenko Natalia I. 
Published: August 2022

Abstract
This article summarizes the results of systematization of monitoring heterogeneous weather records (1961–2014) and interpretation of long-term observations of fluoride ion concentration in the snow cover of an area susceptible to emissions from an aluminum smelter in 2000–2014. The monitoring was carried out by the Federal Service for Hydrometeorology and Environmental Monitoring of Russia. The trends and correlation coefficients established in this study show that F concentration in the snow cover is affected by the following concurrent factors: distance from the emission source, amount of atmospheric precipitation, air temperature and duration of thaws during the period starting from formation of a stable snow cover to the date of sampling. These results emphasize the need to consider the weather factor in the future in the annual comparison of fluoride ion concentrations in the snow cover in order to increase the reliability of data on the changes in fluorine emissions from an aluminum smelter over many years.
Use of a Clinical Guideline and Orderset to Reduce Hospital Admissions for Croup
Authors: Hester Gabrielle , Nickel Amanda J. , Watson David , Maalouli Walid , Bergmann Kelly R. 
Published: August 2022

BACKGROUND
Studies have found infrequent interventions after croup admission. Our objectives were to achieve 25% reduction in (1) admission rate and (2) neck radiograph utilization among patients presenting to the emergency department.

METHODS
At our tertiary children’s hospital, we implemented clustered interventions including education, guideline, and orderset integration. We included patients 3 months to 8 years old with an emergency department, observation, or inpatient encounter for croup. We excluded patients with direct or ICU admissions, complex chronic conditions, or concurrent asthma, pneumonia, or bronchiolitis. We reviewed a random sample of 60% of encounters from baseline (October 1, 2017 to September 30, 2019) and implementation (October 1, 2019 to September 30, 2020) periods. We conducted a posthoc analysis from October 1, 2017 to December 1, 2021 to assess sustainment during coronavirus disease 2019. Interrupted time series analysis was used to evaluate changes in outcome, process, and balancing measures.

RESULTS
There were 2906 (2123 baseline and 783 implementation) encounters included. Extrapolating preintervention trend estimates, the baseline admission rate of 8.7% decreased to 5.5% postintervention (relative decrease 37% [95% confidence interval: 8 to 66]) and sustained over 26 months after implementation. Admission rate in patients receiving 2 or fewer racemic epinephrine was significantly lower in implementation (1.7%) compared with baseline (6.3%), relative decrease of 72% (95% confidence interval: 68 to 88). There were no significant changes in neck radiographs, length of stay, or revisits.

CONCLUSIONS
Croup quality improvement interventions were associated with a significant decrease in hospital admissions with no increase in revisits.
Stability, nutritional composition, and antioxidant properties of surfactant-assisted enzymatically extracted tiger nut milk
Authors: Adedeji O.E. , Yohanna K. , Adedeji O.G. , Yunusa B.M. , Ango A.N. 
Published: August 2022

Abstract
This study evaluated the effect of surfactant-assisted enzymatic extraction on the quality of tiger nut milk (TNM). TNM was extracted from tiger nuts using different concentrations of xylanase (0.010–0.100%) and Tween 20 (0.005–0.010%). The yield, stability, nutritional, antioxidant, and sensory properties of the samples were determined. The yield of TNM significantly increased, by 32.72–50.67%, following surfactant-assisted enzymatic extraction. Optimum yield and stability of TNM were obtained using 0.010% xylanase and Tween 20. Enzymatic extraction significantly increased total sugar and flavonoids, however, starch, dietary fibre, protein, carotenoids, lycopene, total phenolic content, and antioxidant properties reduced significantly. The incorporation of Tween 20 stabilised these parameters. There was no significant difference in panellists' preference for the control (sample extracted without enzyme and surfactant), enzymatically-extracted, and surfactant-assisted enzymatic extracted samples in mouthfeel and aroma, however, the surfactant-assisted enzymatic extracted sample was most preferred in colour, consistency, taste, and overall acceptability. Using surfactant-assisted enzymatic extraction could prove invaluable for the production of TNM.
Blocking CCL8-CCR8–Mediated Early Allograft Inflammation Improves Kidney Transplant Function
Authors: Dangi Anil , Husain Irma , Jordan Collin Z. , Yu Shuangjin , Natesh Naveen , Shen Xiling , Kwun Jean , Luo Xunrong 
Published: August 2022

Significance Statement
In a mouse allograft model, the CCL8-CCR8 axis mediated early kidney inflammation through donor kidney resident macrophages. The revealed therapeutic targets could expand the transplantable donor kidney pool and promote kidney allograft longevity.

Background
In kidney transplantation, early allograft inflammation impairs long-term allograft function. However, precise mediators of early kidney allograft inflammation are unclear, making it challenging to design therapeutic interventions.

Methods
We used an allogeneic murine kidney transplant model in which CD45.2 BALB/c kidneys were transplanted to CD45.1 C57BL/6 recipients.

Results
Donor kidney resident macrophages within the allograft expanded rapidly in the first 3 days. During this period, they were also induced to express a high level of Ccl8, which, in turn, promoted recipient monocyte graft infiltration, their differentiation to resident macrophages, and subsequent expression of Ccl8. Enhanced graft infiltration of recipient CCR8+ T cells followed, including CD4, CD8, and γδ T cells. Consequently, blocking CCL8-CCR8 or depleting donor kidney resident macrophages significantly inhibits early allograft immune cell infiltration and promotes superior short-term allograft function.

Conclusions
Targeting the CCL8-CCR8 axis is a promising measure to reduce early kidney allograft inflammation.
SISTEM INFORMASI PENGOLAHAN DATA HASIL TES PEMANDUAN BAKAT CABANG OLAHRAGA SENAM
Authors: Fitri Mustika 
Published: August 2022

Penelitian ini menghasilkan suatu program aplikasi sistem pengolahan data hasil tes pemanduan bakat cabang olahraga senam yang dapat mempercepat pemberian informasi tentang parameter antropometrik dan kualitas fisik serta motorik atlet senam, yang tersimpan secara lengkap dalam suatu database. Dalam menyelesaikan program aplikasi penelitian ini, Penulis menggunakan bahasa pemrograman Microsoft Visual Basic 6.0. yang dapat: (1) Menghasilkan suatu sistem informasi yang cepat dan benar dalam mengevaluasi parameter antropometrik calon atlit senam sebelum dibina lebih lanjut. (2) Menghasilkan suatu sistem informasi yang cepat dan benar dalam menentukan bentuk latihan yang tepat sesuai dengan kualitas fisik dan motorik atlit senam. (3) Menghasilkan suatu suatu program aplikasi sistem informasi pengolahan data hasil tes pemanduan bakat cabang olahraga senam (artistic dan ritmik) dengan database, berupa model proses/fungsional, model data, modul program, dan antar muka perangkat lunak.