bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the dynamics of Hilfer fractional operator associated with certain electric circuit models
Authors: Ibrahim Nuruddeen Rahmatullah , Gómez‐Aguilar J.F. , Garba Ahmad Abdulaziz , Ali Khalid K. 
Published: April 2022

SummaryThe present manuscript investigates the action of the Hilfer fractional operator on the dynamics of resistor–capacitor (RC) and certain resistor–inductor‐capacitor (RLC) electric circuits using the Laplace transform method alongside utilizing the negative binomial formula. The choice of Hilfer's operator here was basically based on its interpolating nature between the well‐known Caputo and Riemann–Liouville fractional derivatives. Meanwhile, this operator has not been adequately scrutinized with regard to its effects on electric circuits in the literature. Thus, respective approximate exact solutions are determined convolutionally in the presence of certain periodic voltage source functions. Lastly, the significance of the operator on the dynamics of these models was demonstrated graphically for different values of the fractional‐order
and type
. More so, the present study will be beneficial in designing modern electric devices involving temporal delays and memory record.
Marginalized adult learners faced unique challenges during COVID‐19
Authors: Sutton Halley 
Published: April 2022

SAN DIEGO, CALIFORNIA — “It's been my privilege to work with adult learners all the time,” Royce Ann Collins, Ph.D., Associate Professor of Adult Learning and Leadership at Kansas State University, said. Collins has worked with partner organizations, including working with the DeBruce Foundation, to conduct research on adult scholars at various programs, including the differences between adult learners and traditional students.
Can heat‐pumps provide routes to decarbonization of building thermal control in the US Midwest?
Authors: Doak Austin , Stanier Charles , Anthony Jerry , Udaykumar H. S. 
Published: April 2022

AbstractClimate change mitigation demands rapid decarbonization; in cold regions such as the US Midwest, building thermal control (BTC) presents a potential for significant cuts in emissions by combining renewable energy with heat pumps. Trends in natural gas and electricity pricing over the period 2007–2020 have significantly upended economic feasibility of this decarbonization approach. Heat pump‐based BTC has moved from being cost advantageous in operations but higher GHG emitting (in 2007), to the exact opposite—higher cost but lower emitting (in 2020). Due to energy price fluctuations, the coefficient of performance required of a heat pump to breakeven on operational cost with high efficiency natural gas heating has doubled, changing from 2.25 to 4.5 over the period 2007–2019. The value of 4.5 is infeasible for all available cold‐climate heat pump systems. Thus, while electrification via both air‐source and ground‐source heat pumps is a commonly identified component of decarbonization plans in the region, actual implementation has declined. Improvements in heat pump performance, overcoming adoption barriers, and adopting policies that buffer long‐term climate solutions against short‐term price fluctuations are all needed. In part due to continuing decreases in carbon intensity of electricity, heat pump climate benefits can be substantial over project life cycles; however, there is no current policy mechanism to enable this benefit to be considered relative to short‐run economic considerations.
A comparison of using organic Rankine and Kalina cycles as bottom cycles in a solar‐powered steam Rankine cycle
Authors: Mirjavadi Koosha , Pourfayaz Fathollah , Pourmoghadam Peyman , Kasaeian Alibakhsh 
Published: April 2022

AbstractThis study has attempted to compare two thermodynamic cascade cycles, which in this paper are presented as Systems A and B. System A was consisted of a steam Rankine cycle (SRC) as a top cycle and an organic Rankine cycle (ORC) as a bottom cycle. System B was consisted of the same SRC as the top cycle and a Kalina cycle as the bottom cycle. The comparison of both systems has been made by changing a number of parameters. The chosen parameters for this comparison were bottom cycle mass flow rate, aperture area of the collector, top cycle condensing pressure, and bottom cycle turbine inlet and outlet pressures. Also, a short economic evaluation has been made between two proposed cascade cycles (Systems A and B). The result indicated that the Kalina cycle shows superiority over the ORC as the bottom cycle in a solar‐driven SRC. Furthermore, it was determined that the most effective parameters on the overall efficiency of the systems are the condensing pressure of the top cycle and the outlet pressure of the bottom cycle turbine. Also, among the chosen parameters, the outlet pressure of the bottom cycle turbine had the highest effect on the efficiency of the bottom cycles. Considering the economic aspect, the results showed that the levelized costs of energy for both systems are quite equal at 0.011 ($/kWh).
Rheological and functional characterization of gelatin and fat extracted from chicken skin for application in food technology
Authors: Mohammadnezhad Sedigheh , Farmani Jamshid 
Published: April 2022

AbstractChicken skin is a major byproduct of the poultry industry. This study was undertaken to extract and characterize fat and gelatin from chicken skin. To do this, the chicken skin was wet‐rendered at different temperature–time combinations and the yield and properties of the extracted gelatin and fat were determined. Gelatin and fat were recovered at yield ranges of 0.74%–2.03% and 24.01%–27.91%, respectively. The time and the interaction of time–temperature had a positive effect on gelatin yield (p < .05); however, the fat yield was not affected by the extraction condition. Protein, ash, and hydroxyproline content of gelatin and unsaponifiables and free fatty acids contents, peroxide value, and induction period of oxidation of the fat were affected by the extraction condition. Functional and rheological analyses showed chicken skin gelatin gel/solution had a higher bloom value, viscosity, foaming capacity, storage and loss moduli, and melting and gelling points than the commercial bovine gelatin. Oleic (42.13%), palmitic (24.6%), and linoleic (17.53%) acids were the main fatty acids of chicken skin fat. The storage modulus of chicken skin fat was higher than the loss modulus up to 31°C; however, because of a low slip melting point (22.74°C) and solid fat content, it was fluid at room temperature. The findings of this research can be useful in the development of processes for the extraction and application of chicken skin gelatin and fat.
Creative performance pressure as adouble‐edgedsword for creativity: The role of appraisals and resources
Authors: Liu Fangzhou , Li Peikai , Taris Toon W. , Peeters Maria C. W. 
Published: April 2022

AbstractCreativity, or the generation of novel and useful ideas or products, is widely viewed as the cornerstone of organizational innovation and success. However, high pressure to be creative may have mixed implications for employee creativity. In this article, we first systematically conceptualize the nature of the concept of creative performance pressure. Next, building on transactional stress theory, we investigate (a) how creative performance pressure influences employee creativity through different appraisals (i.e., challenge and hindrance) and (b) the moderating role of a job and personal resource (i.e., servant leadership and promotion focus) in the stressor appraisal process. In Study 1, we developed a creative performance pressure scale and assessed its psychometric properties across two samples (N = 181 for Sample 1;N = 253 for Sample 2). In addition, using multi‐wave, multi‐source data (Study 2), we tested our hypotheses in a Chinese sample (N = 206). The results demonstrated that creative performance pressure can have both positive and negative effects on employee creativity through challenge and hindrance appraisals, respectively. Servant leadership moderated the effect of creative performance pressure on challenge and hindrance appraisals, by transmitting the beneficial and detrimental effects of creative performance pressure to creativity, respectively. Similarly, promotion focus moderated the relationship between creative performance pressure and hindrance appraisal. We discuss future research directions and offer several practical implications for both organizational leaders and human resource (HR) practitioners.
Environmental monitoring tools and strategies in salmon net-pen aquaculture
Authors: Bell Jennifer L. , Mandel Randy , Brainard Andrew S. , Altschuld Jon , Wenning Richard J. 
Published: April 2022

Abstract
As global salmon production accelerates in response to higher consumer demand for seafood, so does the need for sophisticated monitoring strategies to enable and maintain ethically sound, productive, and environmentally friendly production of fish. Innovative technologies are needed to ensure proper water quality, react to unfavorable hydrodynamic conditions, monitor for changes in fish health, and minimize ecological interactions with indigenous aquatic life, including fish escapes. Automated sensors connected wirelessly to data stations, visualization aids, and acoustic and physical tagging technologies are emerging tools capable of detecting environmental stress and its associated behavioral changes in farmed fish. Computer modeling of the monitoring data collected from a single salmon farm or collection of farms sharing a data network can be used to spot environmental trends vital for anticipating some of the consequences of climate change. Environmental regulations governing salmon farming in coastal areas are becoming more stringent in response to public pressures to protect coastal and ocean resources and to provide for multipurpose use of marine resources. As net-pen salmon aquaculture expands globally, new technologies will be essential to collect and interpret the anticipated larger volumes of data needed to meet these stringent regulatory requirements and to safeguard the high investment costs inherent in salmon farming. Integr Environ Assess Manag 2022;18:950–963. © SETAC
KEY POINTS
Innovative technologies are needed to ensure proper water quality, react to unfavorable hydrodynamic conditions, monitor for changes in fish health, and minimize ecological interactions with indigenous aquatic life. Automated sensors connected wirelessly to data stations, visualization aids, and acoustic and physical tagging technologies are emerging tools capable of detecting environmental stress and its associated behavioral changes in farmed fish. As net-pen salmon aquaculture expands globally, new technologies will be essential to collect and interpret the anticipated larger volumes of data needed.
Identification of B‐cell dominant epitopes in the recombinant protein P29 from Echinococcus granulosus
Authors: Lv Yongxue , Li Shasha , Zhang Tingrui , Zhu Yazhou , Tao Jia , Yang Jihui , Chang Liangliang , Wu Changyou , Zhao Wei 
Published: April 2022

AbstractIntroductionEchinococcus granulosus (E. granulosus) causes a hazardous zoonotic parasitic disease. This parasite can occupy the liver and several areas of the body, causing incurable damage. Our previous studies have provided evidence that the recombinant protein P29 (rEg.P29) exhibit immune protection in sheep and mice against pathological damage induced by E. granulosus, showing its potential as candidate for vaccine development. However, information on the B‐cell epitopes of rEg.P29 has not yet been reported.MethodsImmunological model was established in mice with rEg.P29. SDS‐PAGE and Western blot were used to identify protein. Screening for B‐cell dominant epitope peptides of rEg.P29 by enzyme‐linked immunosorbent assay (ELISA) and immune serum. Dominant epitopes were validated using ELISA and flow cytometry. Multiple sequence alignment analysis was performed using BLAST and UniProt.ResultsImmunization with rEg.P29 induced intense and persistent antibody responses, and the epitope of the dominant antigen of B cells are identified as rEg.P29166–185 (LKNAKTAEQKAKWEAEVRKD). Anti‐rEg.P29166–185‐specific antibodies lack epitopes against IgA, IgE, and IgG3, compared to anti‐rEg.P29‐specific antibodies. However, anti‐rEg.P29166–185 IgG showed comparatively higher titers, as determined among those peptides by endpoint titration. In addition, rEg.P29 and rEg.P29166–185 promote B‐cell activation and proliferation in vitro. The dominant epitopes are relatively conserved in different subtypes of the rEg.P29 sequence.ConclusionrEg.P29166–185 can act as a dominant B‐cell epitope for rEg.P29 and promote cell activation and proliferation in the same way as rEg.P29.
Risk of nonpulmonary infections requiring hospitalization in spondyloarthritis
Authors: Chung Ho Yin , Chan Shirley Chiu Wai , Sun Frances Sze Kei 
Published: April 2022

AbstractObjectivesTo compare the risk of five nonpulmonary infections leading to hospitalization between spondyloarthritis (SpA) and nonspecific back pain (NSBP), and to identify the risk factors.MethodsA total of 3018 patients with SpA and 2527 patients with NSBP were identified. Data from December 1995 to June 2019 was retrieved from a centralized electronic medical record system. The date of onset of five types of nonpulmonary infections including: urinary tract infection (UTI), skin infection, gastroenteritis (GE), septic arthritis, and pancreato‐hepatobiliary tract infection were identified. Demographic data, comorbidities, and medications used were also retrieved. Comparative risk of each type of infection between SpA and NSBP was determined using propensity score adjustment method. Cox regression model was used to identified risk factors.ResultsPatients with SpA were younger in age, predominantly male, with fewer comorbid diabetes mellitus (DM), renal impairment, and depression. Compared with NSBP, patients with SpA had higher risk of UTI (hazard ratio [HR] 1.91; p < .001), skin infection (HR 1.79; p < .001), and septic arthritis (HR 4.57; p = .04). Risk of GE (HR 1.42; p = 1.00), and pancreato‐hepatobiliary tract infection (HR 1.67; p = .06) were not increased. Infliximab was an independent risk factor for UTI (HR 2.21; p = .04). Duration of steroid therapy >6 months (HR 2.22; p < .001), smoker (HR 1.81; p < .001), and psoriasis (HR 2.47; p < .001) were risk factors for skin infection.ConclusionSpA was associated with increased risk of UTI, skin infection, and septic arthritis. Infliximab, prolonged steroid therapy, smoking, and psoriasis were associated risk factors.
Elevated circulating myeloid‐derived suppressor cells associated with poor prognosis in B‐cell non‐Hodgkin's lymphoma patients
Authors: Wang Yangyang , Wang Jiyu , Zhu Fengfeng , Wang Huiping , Yi Liuying , Huang Keke , Zhai Zhimin 
Published: April 2022

AbstractIntroductionMyeloid‐derived suppressor cells (MDSCs) are a heterogeneous cell population with the ability to suppress immune responses. MDSCs usually cluster in cancer, inflammation, and autoimmune diseases. Although there have been some studies on MDSCs in non‐Hodgkin lymphoma (NHL), the correlation between the peripheral levels of MDSCs in patients with various subtypes of B cell NHL and clinical features and prognosis remains inconclusive. This study aimed at the issue.Methods101 patients with B cell NHL and 15 age‐matched healthy controls were included in this study. Flow cytometric detection of monocytic‐MDSCs (M‐MDSCs) and granulocytic‐MDSCs (G‐MDSCs) was done.ResultsIn this study, we found that counts of circulating M‐MDSCs and G‐MDSCs were significantly increased in different clinical statuses of B‐NHL patients compared to healthy controls. Similarly, a significant increase in the levels of M‐MDSCs and G‐MDSCs was found among the diverse types of B‐NHL compared with healthy donors. Stratification studies indicated MDSCs expansion was closely associated with disease progression (tumor stage, LDH levels and B syndromes). Moreover, the overall survival time of patients with G‐MDSCs (%) ≥ 98.70% was shorter than patients with G‐MDSCs (%) < 98.70% in newly diagnosed B‐NHL subgroup, meanwhile, there was a significant difference in survival of patients with M‐MDSCs (%) ≥ 7.19% compared to patients with M‐MDSCs (%) < 7.19% in relapsed B‐NHL subgroup.ConclusionOur results suggested that M‐MDSCs and G‐MDSCs may be a potential and efficient index to evaluate the prognosis of B‐NHL patients.
Cell‐free DNA as a biomarker after lung transplantation: A proof‐of‐concept study
Authors: Magnusson Jesper M. , Ricksten Anne , Dellgren Göran , Wasslavik Carina , Nordén Rickard , Westin Johan , Boehmer Jens 
Published: April 2022

AbstractBackgroundLung transplantation (LTx) is a lifesaving procedure burdened with limited long‐term survival. The most common cause of death after LTx is chronic lung allograft dysfunction (CLAD). Today, useful biomarkers for the detection of CLAD are lacking. Circulating cell‐free DNA (cfDNA) is released during cellular decay and can be detected using polymerase chain reaction (PCR). Thus, donor‐derived cfDNA in recipient serum indicates cellular decay in the transplanted organ. In the current study, we explore the possibility of using a novel PCR method to detect cfDNA as a biomarker for clinical events, especially CLAD.MethodsFour patients were retrospectively tested for levels of both donor and recipient‐derived cfDNA using digital droplet PCR after targeted preamplification. The results were correlated to recorded clinical events.ResultsAll available samples rendered results. Both patients that later developed CLAD showed a persistently elevated ratio between donor‐and recipient‐derived cfDNA. Also, the mean level of cfDNA was higher in the two patients who later developed CLAD than in patients who did not (p = .0015).ConclusionsThis proof‐of‐concept study suggests that cfDNA quantified with PCR may be used as a biomarker of significant clinical events such as CLAD.
Evaluating outcomes of a clinical pharmacist medication management program in a multidisciplinary practice for outpatient buprenorphine treatment of opioid use disorder
Authors: Mattle Anna G. , Aladeen Traci , Blondell Richard D. , Capote Horacio , Rainka Michelle 
Published: April 2022

AbstractIntroductionTreatment with medications such as buprenorphine has been shown to improve outcomes of patients with opioid use disorder (OUD); however, there is still potential to optimize care. Clinical pharmacists may benefit OUD patient treatment by making individualized medication recommendations and enhancing care as part of a multidisciplinary team. This study evaluates a novel outpatient practice model that incorporates pharmacists to manage OUD patients.MethodsA multi‐center retrospective study compared outcomes of a multidisciplinary practice with clinical pharmacists to a physician‐only practice. Primary outcomes were treatment retention and opioid relapse rate. Secondary outcomes included patient engagement with counseling, toxicology results, and buprenorphine nonadherence. Data were collected from 75 patient records from each practice for up to 1 year after starting treatment. In addition, a prospective, observational study was conducted to describe pharmacist interventions at the multidisciplinary practice. Twenty patients were followed for up to 1 year to characterize pharmacist recommendations and assess treatment retention and opioid relapse rates among other secondary measures.ResultsIn the retrospective study, treatment retention did not differ between practices (P > .05) but multidisciplinary practice patients experienced fewer opioid relapse months (P < .05). Similar rates of engagement with counseling (P = 1) and follow‐up visits with illicit substance use (P > .05) were observed. More buprenorphine nonadherence was identified at the physician practice (P < .01). In the prospective study, pharmacist recommendations included buprenorphine regimen changes and the addition of new medications for un/undertreated conditions. Pharmacists provided care coordination, medication counseling, non‐pharmacologic recommendations, and counseling regarding future/alternative treatment options.ConclusionThis study demonstrates the ability of a practice with clinical pharmacists to provide quality care to OUD patients in an outpatient setting. These results have implications for OUD treatment by expanding addiction services in this underserved patient population.
Continuous glucose monitoring shared medical appointments improve diabetes self‐efficacy and hemoglobin A1C
Authors: Simonyan Anahit R. , Isaacs Diana , Lekic Sanela , Blanchette Julia E. , Noe Dawn , Galloway Nicholas R. 
Published: April 2022

AbstractIntroductionDiabetes self‐management education and support and professional continuous glucose monitoring (CGM) were combined into shared medical appointments (SMA) to provide care for people with diabetes. Although the individual components have evidence of efficacy, this combination has never been studied.ObjectivesThe purpose of this study is to assess the impact of CGM SMA on diabetes self‐efficacy and hemoglobin A1C (A1C) in persons with diabetes.MethodsAdults who attended a two‐part CGM SMA at a large academic medical center were included in this retrospective, pre‐post study. The CGM SMA incorporated diabetes education, peer support, and seven days of professional CGM. The primary outcome was change in diabetes self‐efficacy through a validated eight‐item Likert Scale instrument. Secondary objectives were changes in A1C, changes in diabetes medications, and type of planned lifestyle changes. Paired t tests were used to analyze change in A1C and diabetes self‐efficacy scores.ResultsA total of 171 participants were included in this analysis. Diabetes self‐efficacy scores increased by a mean of 1.63 ± 2.09 points (P < .001) out of 10 points maximum after participation in the two‐part CGM SMA. The A1C decreased by a mean of 0.80 ± 1.52% (P < .001), with a mean follow‐up A1C of 7.8 ± 1.60%. Those with an A1C > 8% (n = 101) experienced a decrease of 1.20%. Participants utilizing the unblinded device (n = 133) experienced a decrease in A1C by 0.75% compared with 1.0% in those that utilized a blinded device (n = 38). Most medication changes made in the CGM SMA were dosage adjustments and changes in administration time.ConclusionsThe CGM SMA is a novel practice model incorporating diabetes education, peer support, professional CGM, and interprofessional care that demonstrated improvements in diabetes self‐efficacy and A1C.