bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID-19 on cancer screening: a global perspective
Authors: Allahqoli Leila , Mazidimoradi Afrooz , Salehiniya Hamid , Alkatout Ibrahim 
Published: July 2022

Purpose of review
Cancer screening disruption due to COVID-19 may have a significant impact on patients, healthcare practitioners, and healthcare systems. In this present review, we aim to offer a comprehensive view of the effect of the COVID-19 pandemic on cancer screening programs worldwide.

Recent findings
The present review comprised 33 publications. During the COVID-19 pandemic, the rates of cancer screening investigations were drastically reduced worldwide. Screening rates plummeted for all types of cancer, all ages, and racial/ethnic groups. Reductions in screening percentages were higher in several underserved racial groups. Cancer screening was suspended for at least 30 days in 13 countries.

Summary
Screenings for all types of cancer fell sharply. In the chain of cancer management, delays in any step are liable to change the outcome of the next step. Further long-term research will be needed to fully comprehend the impact of the pandemic on cancer services and patient outcomes.
Clinical Effectiveness of SARS-CoV-2 Vaccination in Renal Transplant Recipients. Antibody Levels Impact in Pneumonia and Death
Authors: Rodríguez-Cubillo Beatriz , Moreno de la Higuera M. Angeles , Pérez-Flores Isabel , Calvo Romero Natividad , Aiffil Arianne Sofía , Arribi Vilela Ana , Peix Belen , Huertas Sara , Juez Almudena , Sanchez-Fructuoso Ana I. 
Published: July 2022

Background.
Few studies have described the clinical impact of anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in renal transplant recipients (RTRs) in the context of omicron variant and the third vaccine dose. Antibody titer has been tried to relate to the prediction of outcomes related to SARS-CoV-2, but it results controversially in these populations.

Methods.
All patients with positive SARS-CoV-2 polymerase chain reaction followed at a RTRs reference center from March 15, 2020, to March 15, 2022, were considered for analysis. Cases were analyzed by vaccination status. Breakthrough cases were then analyzed by nonantibodies (<20 arbitrary unit [AU]/mL), low (20–100 AU/mL), and high antibody titers (>100 AU/mL) against SARS-CoV-2 spike protein. Outcomes included pneumonia and mortality. We used logistic regression multivariable to assess for confounders.

Results.
Among 186 RTRs with coronavirus disease 2019, 50.5% (n = 94) were vaccinated versus 49.5% (n = 92) unvaccinated. Of the vaccinated patients, 67.02% developed a high antibody titer (>100 AU/mL) but 14.89% achieved a low antibody titer and 18.08%. Pneumonia-free survival (day 20) was 95% in high antibody titer but 40% in unvaccinated RTRs. Survival in RTRs at day 60 was similar in the unvaccinated group compared with nonantibodies breakthrough cases (82%) but 92% in the low antibody titer group (relative risk, 0.027; 95% confidence interval, 0.002-0.479; P = 0.014). Only patients with >100 AU/mL showed a 100% survival on day 60 postinfection.

Conclusions.
Vaccinated RTRs who achieve at least a low antibody titer (>20 AU/mL) had better results in terms of pneumonia and mortality than unvaccinated RTRs. Antibody titer >100 AU/mL associate with even better results than patients with lower antibody titers.
Relationship between salmon egg subsidy and the distribution of an avian predator
Authors: Yamada Taihei , Katahira Hirotaka , Miura Kazuki , Nakamura Futoshi 
Published: July 2022

ABSTRACTAs a spatial subsidy, which is the phenomenon of transferring resources from a donor system to a recipient system, anadromous salmonids contribute to the supply of marine-derived nutrients to freshwater and terrestrial systems. Live salmon and salmon carcasses and eggs are utilized by various organisms and affect their abundance and distribution. However, the evaluation of the effect of salmon subsidies on the abundance and distribution of terrestrial animals is biased towards predators or scavengers that utilize spawning adults and carcasses, and few studies have focused on the effect of salmon eggs as a subsidy. To avoid underestimating the function of salmon subsidies, the response to the availability of salmon eggs in various systems should be investigated. Here, we investigated the abundance and feeding behaviour of the brown dipperCinclus pallasii, as salmon egg a consumer, based on the hypothesis that the availability of salmon eggs affects the diet composition and stream distribution of this small predator. In addition, to test whether changes in the abundance of brown dippers are determined by salmon spawning, their abundance was compared upstream and downstream of the dam. Brown dippers used salmon eggs during the spawning season (53.7% of diet composition), and their abundance increased as the number of spawning redds increased. In contrast, this pattern was not observed upstream of the dam. These results suggested that the abundance and stream distribution of brown dippers vary according to the variation in the spatiotemporal availability of salmon eggs.
The Spatial Organization of Bacterial Transcriptional Regulatory Networks
Authors: Tian Liu , Liu Tong , Hua Kang-Jian , Hu Xiao-Pan , Ma Bin-Guang 
Published: July 2022

AbstractTranscriptional regulatory network (TRN) is the central pivot of a prokaryotic organism to receive, process and respond to internal and external environmental information. However, little is known about its spatial organization so far. In recent years, chromatin interaction data of bacteria such asEscherichia coliandBacillus subtilishave been published, making it possible to study the spatial organization of bacterial transcriptional regulatory networks. By combining TRNs and chromatin interaction data ofE. coliandB. subtilis, we explored the spatial organization characteristics of bacterial TRNs in many aspects such as regulation directions (positive and negative), central nodes (hubs, bottlenecks), hierarchical levels (top, middle, bottom) and network motifs (feed-forward loops and single input modules) of the TRNs and found that the bacterial TRNs have a variety of stable spatial organization features under different physiological conditions which may be closely related with basic life activities. Our findings provided new insights into the connection between transcriptional regulation and the spatial organization of chromosome in bacteria, and might serve as a foundation for spatial-distance-based gene circuit design in synthetic biology.
Estimating functional EEG sources using topographical templates
Authors: Poncet Marlene , Ales Justin 
Published: July 2022

AbstractElectroencephalography (EEG) is a common and inexpensive method to record neural activity in humans. However, it lacks spatial resolution making it difficult to determine which areas of the brain are responsible for the observed EEG response. Here we present a new easy-to-use method that relies on EEG topographical templates. Using MRI and fMRI scans of 50 participants, we simulated how the activity in each visual area appears on the scalp and averaged this signal to produce functionally defined EEG templates. Once created, these templates can be used to estimate how much each visual area contributes to the observed EEG activity. We tested this method on extensive simulations and on real data. The proposed procedure is as good as bespoke individual source localization methods and has several strengths. First, because it does not rely on individual brain scans, it is inexpensive and can be used on any EEG dataset, past or present. Second, the results are readily interpretable in terms of functional brain regions and can be compared across neuroimaging techniques. Finally, this method is easy to understand, simple to use, and expandable to other brain sources. We thus expect it to be of wide interest to EEG users.
Artifacts can be deceiving: The actual location of deep brain stimulation electrodes differs from the artifact seen on magnetic resonance images
Authors: Nuzov Noa B. , Bhusal Bhumi , Henry Kaylee R. , Jiang Fuchang , Vu Jasmine , Rosenow Joshua M. , Pilitsis Julie G. , Elahi Behzad , Golestanirad Laleh 
Published: July 2022

AbstractIntroductionDeep brain stimulation (DBS) is a common treatment for a variety of neurological and psychiatric disorders. Recent studies have highlighted the role of neuroimaging in localizing the position of electrode contacts relative to target brain areas in order to optimize DBS programming. Among different imaging methods, postoperative magnetic resonance imaging (MRI) has been widely used for DBS electrode localization; however, the geometrical distortion induced by the lead limits its accuracy. In this work, we investigated to what degree the difference between the actual location of the lead’s tip and the location of the tip estimated from the MRI artifact varies depending on the MRI sequence parameters such as acquisition plane and phase encoding direction, as well as the lead’s extracranial configuration. Accordingly, an imaging technique to increase the accuracy of lead localization was devised and discussed.MethodsWe designed and constructed an anthropomorphic phantom with an implanted DBS system following 18 clinically relevant configurations. The phantom was scanned at a Siemens 1.5 Tesla Aera scanner using a T1MPRAGE sequence optimized for clinical use and a T1TSE sequence optimized for research purposes. We varied slice acquisition plane and phase encoding direction and calculated the distance between the caudal tip of the DBS lead MRI artifact and the actual tip of the lead, as estimated from MRI reference markers.ResultsImaging parameters and lead configuration substantially altered the difference in the depth of the lead within its MRI artifact on the scale of several millimeters − with a difference as large as 4.99 millimeters. The actual tip of the DBS lead was found to be consistently more rostral than the tip estimated from the MR image artifact. The smallest difference between the tip of the DBS lead and the tip of the MRI artifact using the clinically relevant sequence (i.e., T1MPRAGE) was found with the sagittal acquisition plane and anterior-posterior phase encoding direction.Discussion/ConclusionThe actual tip of an implanted DBS lead is located up to several millimeters rostral to the tip of the lead’s artifact on postoperative MR images. This distance depends on the MRI sequence parameters and the DBS system’s extracranial trajectory. MRI parameters may be altered to improve this localization.
Evolutionary-scale prediction of atomic level protein structure with a language model
Authors: Lin Zeming , Akin Halil , Rao Roshan , Hie Brian , Zhu Zhongkai , Lu Wenting , Smetanin Nikita , Verkuil Robert , Kabeli Ori , Shmueli Yaniv , dos Santos Costa Allan , Fazel-Zarandi Maryam , Sercu Tom , Candido Salvatore , Rives Alexander 
Published: July 2022

AbstractArtificial intelligence has the potential to open insight into the structure of proteins at the scale of evolution. It has only recently been possible to extend protein structure prediction to two hundred million cataloged proteins. Characterizing the structures of the exponentially growing billions of protein sequences revealed by large scale gene sequencing experiments would necessitate a break-through in the speed of folding. Here we show that direct inference of structure from primary sequence using a large language model enables an order of magnitude speed-up in high resolution structure prediction. Leveraging the insight that language models learn evolutionary patterns across millions of sequences, we train models up to 15B parameters, the largest language model of proteins to date. As the language models are scaled they learn information that enables prediction of the three-dimensional structure of a protein at the resolution of individual atoms. This results in prediction that is up to 60x faster than state-of-the-art while maintaining resolution and accuracy. Building on this, we present the ESM Metage-nomic Atlas. This is the first large-scale structural characterization of metagenomic proteins, with more than 617 million structures. The atlas reveals more than 225 million high confidence predictions, including millions whose structures are novel in comparison with experimentally determined structures, giving an unprecedented view into the vast breadth and diversity of the structures of some of the least understood proteins on earth.
Understanding the purchase intention of fitness wearables: using value-based adoption model
Authors: Mathavan Bushan , Vafaei-Zadeh Ali , Hanifah Haniruzila , Ramayah T. , Kurnia Sherah 
Published: July 2022

PurposeThis paper aims to investigate the key enablers and inhibitors that influence the intention to use fitness wearables using the value-based adoption model (VAM).Design/methodology/approachData were collected using a structured online questionnaire from 323 respondents who had never used fitness wearables. A purposive sampling technique was used in this study. Smart PLS was employed to test the research framework and hypotheses using a two-step approach.FindingsThe findings support some of the hypotheses developed with R2 values of 0.622 for perceived value (PV) and 0.567 for intention to use fitness wearable. Perceived enjoyment, perceived social image and perceived usefulness had a positive effect on PV. In addition, health information sensitivity (HIS) was positively related to perceived privacy risk and health information accuracy was positively related to perceived usefulness. Surprisingly, this study did not find any significant relationship between perceived fee, perceived privacy risk, perceived health increase and perceived design aesthetics with PV.Practical implicationsThis study's findings can help designers and manufacturers design fitness wearables by considering factors that users find valuable, thus satisfying consumers' needs.Originality/valueThis study tries to model behavioural intention of fitness wearable usage of individual users by using the VAM with the addition of two new antecedences, HSI and health information accuracy, to better explain the behaviour.
Managing client–consultant relationships to derive benefits from ERP projects
Authors: Bawack Ransome Epie , Kala Kamdjoug Jean Robert 
Published: July 2022

PurposeEnterprise resource planning (ERP) consultants have the expertise required to understand the specific contextual needs of an ERP client, implement tailored business processes that meet those needs, and ensure that no potential benefit offered by the ERP remains unexplored by the client. However, conflicts between ERP clients and consultants are a significant source of non-benefit realisation, making managing client–consultant agency crucial to ERP post-implementation benefits realisation. This paper aims to elucidate how managing client–consultant agency affects the benefits derived from ERP systems.Design/methodology/approachThis paper uses microfinance institutions in 15 sub-Saharan African countries to explore different paths through which managing client–consultant agency leads to benefit realisation in ERP projects. It uses partial least squares structural equation modelling to analyse data from 127 managers and explains the results using insights from agency theory and the information system (IS) success model.FindingsThis paper reveals three routes through which contractual agreements and conflict resolution strategies lead to benefits realisation in ERP projects.Originality/valueThis is the first study that attempts to provide quantitative evidence of how managing the complex relationship between ERP project stakeholders affects ERP project success. It also contributes a novel theoretical model for ERP benefits realisation to complement existing research on ERP agency issues, critical success factors, and benefits realisation.
The grey digital divide and welfare state regimes: a comparative study of European countries
Authors: Alexopoulou Sofia , Åström Joachim , Karlsson Martin 
Published: July 2022

PurposeTechnology access, digital skills, and digital services are increasingly prerequisites for public life and accessing public services. The digital divide in contemporary societies matters for efforts to digitalize the welfare state. Research has already mapped individual determinants of digital exclusion and the existence of an age-related digital divide. However, far less attention has been paid to variations in digital inclusion between countries and to their potential explanations related to political systems. This study explores the influence of variations in welfare regimes on the digital divide among seniors (aged 65+) in Europe.Design/methodology/approachThis article presents time-series cross-sectional analyses of the relationship between welfare state regimes and digital inclusion among seniors in European countries. The analyses are based on data from Eurostat, the World Bank, and the UN E-Government Survey.FindingsThe authors find extensive variation in the digital inclusion of citizens between welfare regimes and argue that considering regime differences improves the understanding of these variations. The findings indicate that the age-related digital divide seems to be least evident in countries with more universalistic welfare regimes and most evident in countries where seniors rely more on their families.Originality/valueThis is the first comparative study of the association between welfare state regimes and digital inclusion among seniors.
The role of enterprise information systems strategies enabled strategy-making on organizational innovativeness: a resource orchestration perspective
Authors: Yoshikuni Adilson Carlos , Dwivedi Rajeev 
Published: July 2022

PurposeThe paper aims to establish the role of enterprise information systems strategies (ISS) enabled by business strategies for attaining organizational innovativeness (ORIN) mediated by performance (decision-making and business processes) under environmental turbulence.Design/methodology/approachThe research framework is developed based on theoretical grounding and validated with the help of 408 responses from Brazil using SmartPLS path modeling.FindingsThe results of the research suggest that the resource orchestra of enterprise information systems strategy-enabled strategy-making can be a viable alternative to enhance innovation activities in the organizations through the mediated role of performance (decision-making and business process).Practical implicationsThe research demonstrates the role of business function (information systems) strategy enabled overall business strategy-making for achieving innovations in the organization. Fortune organizations are exploiting the information systems strategy enabled business strategy for innovations in the organization; such as Amazon, Walmart, Costco, etc.Originality/valueThe proposed and validated model is a contribution to the enterprise information systems strategy theory. This model presents the role of resource orchestras in achieving innovations in organizations.
Socio-spatial appropriations in dwellings of Cairo during lockdown: lessons learned for the post-pandemic era
Authors: Eissa Doha 
Published: July 2022

PurposeThe study examines socio-spatial appropriations in dwellings of Cairo, which were undertaken to expand dwellings affordances and accommodate new utilitarian demands during lockdown. The study questions whether those appropriations impacted dwellers' conceptions of dwellers' dwellings and scrutinizes how those appropriations could feedback the design of dwellings post-pandemic.Design/methodology/approachThe research adopted a mixed-method approach and was constructed over two phases as follows: first, in-depth interviews with 20 participants to acquire qualitative data about the adopted appropriation strategies and the subsequent actualized affordances and second, an online quantitative survey answered by 133 respondents to quantify the frequency of the adopted appropriation strategies and test the relationship between appropriations and mental conceptions of dwellings.FindingsThe study identifies five main appropriation strategies undertaken by dwellers and builds upon them to recommend favorable design features of dwellings post-pandemic. Those are: securing unscripted spaces, reviving dormant spaces, space compartmentalization, temporal programing of space and space esthetic personalization. The study also affirms a relationship between undertaking appropriations and improved mental conceptions of dwellings. Finally, the study suggests recommendations for space use optimization which could be deployed in existing dwellings and could ultimately be considered for designing post-pandemic dwellings.Originality/valueThe originality of this study lies in the study's opportune documentation and analysis of such an exceptional condition. Thus far, very few studies have tackled socio-spatial practices in dwellings during lockdown, let alone the impact of the pandemic on the design of future dwellings.
Countrywide inter‐epidemic region migration pattern suggests the role of southwestern population in wheat stripe rust epidemics in China
Authors: Awais Muhammad , Ali Sajid , Ju Meng , Liu Wei , Zhang Gensheng , Zhang Zedong , Li Zejian , Ma Xinyao , Wang Lin , Du Zhimin , Tian Xiaxia , Zeng Qingdong , Kang Zhensheng , Zhao Jie 
Published: July 2022

AbstractUnderstanding countrywide pathogen population structure and inter‐epidemic region spread is crucial for deciphering crop potential losses. Wheat stripe rust caused by Puccinia striiformis f. sp. tritici is a destructive disease that affects worldwide wheat production, widespread in China, representing largest epidemic region globally. This study aimed to understand the population structure and migration route of P. striiformis f. sp. tritici across China based on sampling from 15 provinces representing six epidemic zones, viz., over‐summering, over‐wintering, eastern, Yun‐Gui, Xinjiang and Tibet epidemic regions. High genotypic diversity was recorded in over‐summering, Tibet and over‐wintering epidemic regions. Epidemic regions partly explain population subdivision with variable divergence (FST = 0.005–0.344). Xinjiang and Tibet epidemic regions were independent epidemic zones with least sharing of genotypes. Among other epidemic zones, i.e. over‐summering, over‐wintering, eastern and Yun‐Gui epidemic zones, re‐sampling MLGs, clustering‐based structure, DAPC analyses, relative migration and low divergence (FST from 0.006 to 0.073) revealed frequent geneflow. Yun‐Gui epidemic regions, with a potential for both over‐summering and over‐wintering, could play an important role in causing epidemics in main wheat‐cultivating areas of China. High diversity, recombination signatures and inter‐epidemic region migration patterns need to be considered in host‐resistant cultivar development in China and neighbouring countries, considering risk of long‐distance migration capacity of pathogen.
Concentration in Asia's cross‐border banking: Determinants and impacts
Authors: Lapid Ana Kristel , Mercado Rogelio , Rosenkranz Peter 
Published: July 2022

AbstractCross‐border bank positions in Asia and the Pacific remain highly concentrated among a few counterparties, exposing the region to financial risks and policy spillovers. Consequently, assessing the determinants and impacts of the region's cross‐border banking concentration is relevant to the design of appropriate policies for promoting financial development and safeguarding financial stability. To this end, we construct cross‐border bank concentration measures for 47 economies in Asia and the Pacific from 2000 to 2019. The results show that higher capital account and trade openness and per capita income are significantly associated with lower cross‐border bank concentration. Moreover, elevated cross‐border bank concentration tends to lower domestic credit and nonperforming loans. We find no impact on bank profitability for the region.