bluuebunny/crossref_metadata_2025_split huggingface dataset:
When Planning Means No Plan: Bidirectional Subjectification in Peninsular Spanish en plan– From Adverbial Phrase to Discourse Marker Functions
Authors: Abella Fernandez Tania 
Published: September 2022

Abstract
Subjectification is a dynamic category in linguistic change as it triggers both grammaticalization and pragmaticalization. In this line, this study traces the evolution of Spanish en plan ‘in plan’ from its origin in the 13th century to the present. I argue that en plan has undergone a bidirectional process of subjectification. Its internal structure has become more fixed, moving from concrete meanings (una clase de literatura, cuyas producciones se semejan en plan, estilo … ‘a kind of literature, whose productions are similar in plan, style …’), to perform approximate adverbial functions (Sus actuaciones (…) son en plan restringido ‘their performances are like restricted’). Moreover, it developed discourse marker functions (le soltó en plan: “oye no es por nada” ‘she said “hey, just saying”’). This implies that the structure has undergone a bidirectional change, first towards the grammar, through grammaticalization, and away from the grammar and towards discourse through a process of discursivization.
Are Verb-Noun Compounds Syntactically or Lexically Related to Verb Phrases?
Authors: Marqueta Gracia Bárbara 
Published: September 2022

AbstractThis paper explores the links between Spanish verb-noun (VN) compounds and verb phrases (VPs) (limpiabotaslit. ‘clean+boots’ ‘shoe shine’/limpiar botas‘to clean boots’), particularly between those with idiomatic meaning (metepataslit. ‘put+paws’ ‘bungler’/meter la patalit. ‘put the paw’ ‘to put your foot in it’). I discuss the theoretical implications of different accounts of the phrase-compound divide, namely, whether or not compounds are created by rules of a different nature than those for phrases (lexicalist vs. neoconstructionist approaches), and whether or not VN compounds can be derived from phrases through applying any kind of transformation. I show that VN compounds share key properties with VPs which could justify their treatment as syntactic objects. By contrast, the VN compound pattern presents unique restrictions that challenge the empirical adequacy of derivational approaches, which are likely to overgenerate ill-formed compounds from existing phrases. Once stored as lexical objects, however, VN compounds and VP idioms may evidence strong semantic connections as illustrated by the pairmetepatas/meter la pata, which suggests the need to carefully examine lexical associations to ensure a balanced understanding of the phrase-compound divide.
Clustered Autoencoded Variational Inverse Reinforcement Learning
Authors: Chen Yuling Max 
Published: September 2022

Abstract
Variational Auto-Encoder (VAE) is a handy and computationally friendly Bayesian tool for Inverse Reinforcement Learning (IRL) problems, with the native setting of absent reward functions in a Markov Decision Process (MDP). However, recent works mainly deal with single reward, which turn out to be insufficient for complex dynamic environments with multiple demonstrators of various characteristics (hence multiple reward functions). This paper extends the dimensionality of reward (from ℝ to ℝ
K
) by incorporating a latent embedding and clustering step on top of a scalable Bayesian IRL model, which enhances her applicability to multi-reward scenarios. We introduce our method, Clustered Autoencoded Variational Inverse Reinforcement Learning (CAVIRL), which is able to approximate multiple posterior reward functions and learn the corresponding policies for experts of various characteristics and skills. As a by-product, the proposed model also thrives to determine the number of clusters K on her own, as opposed to the competing multi-reward imitation learning models that require K to be prespecified. We trained the proposed model within a grid world with multiple types of players, where we achieved 100% correctness in determining the number of players’ types and 80%-83.9% match between the model-learned policies and the players’ demonstrations from the data.
Consumptive hypothyroidism in a patient with malignant rhabdoid tumor of the kidney: case report on a newly found association
Authors: Fiore Roberto , La Rosa Stefano , Uccella Silvia , Marchiori Deborah , Kopp Peter A 
Published: September 2022

Introduction
Consumptive hypothyroidism is a rare paraneoplastic condition most commonly associated with infantile hemangiomas. It is caused by overexpression of deiodinase type 3 (D3), which leads to preferential conversion of thyroxine to the metabolically inactive reverse triiodothyronine (rT3), paralleled by a decrease of the biologically active T3.

Case presentation
A 46-year-old male patient with previously normal thyroid function was diagnosed with a renal carcinoma with rhabdoid differentiation. He was treated with sunitinib, followed by the immune checkpoint inhibitors ipilimumab and nivolumab, and he developed primary hypothyroidism secondary to thyroiditis. Substitution with unusually high doses of levothyroxine as high as 4.3 µg/kg/day did not normalize his thyroid function. Poor compliance was refuted because there was no improvement after observed administration. He had no malabsorption. Although tyrosine kinase inhibitors can increase the expression of D3, this effect tends to be modest. Therefore, the suspicion of tumor-related consumptive hypothyroidism was raised and supported by low free T3 and elevated rT3 levels. The therapy could not be further modified because the patient opted for palliative care and passed away 12 days later.
Immunohistochemistry of the tumor from a sample obtained prior to systemic therapy documented abundant expression of D3, corroborating the diagnosis of consumptive hypothyroidism.

Conclusions
This observation extends the spectrum of malignancies overexpressing D3. Although rare, increased awareness of this paraneoplastic syndrome is key, if persistent hypothyroidism cannot be explained by compliance issues or malabsorption. Substitution with high doses of levothyroxine, and combination therapy with liothyronine, can correct hypothyroidism in these patients.
Neighborhood Child Opportunity and Emergency Department Utilization
Authors: Kaiser Sunitha V. , Hall Matthew , Bettenhausen Jessica L. , Sills Marion R. , Hoffmann Jennifer A. , Noelke Clemens , Morse Rustin B. , Lopez Michelle A. , Parikh Kavita 
Published: September 2022

The Child Opportunity Index measures the structural neighborhood context that may influence a child’s healthy development. We examined relationships between the Child Opportunity Index and emergency department utilization.

BACKGROUND AND OBJECTIVES
The Child Opportunity Index (COI) is a multidimensional measure of structural neighborhood context that may influence a child’s healthy development. Our objective was to determine if COI is associated with children’s emergency department (ED) utilization using a national sample.

METHODS
This was a retrospective cohort study of the Pediatric Health Information Systems, a database from 49 United States children’s hospitals. We analyzed children aged 0 to 17 years with ED visits from January 1, 2018, to December 31, 2019. We modeled associations between COI and outcomes using generalized regression models that adjusted for patient characteristics (eg, age, clinical severity). Outcomes included: (1) low-resource intensity (LRI) ED visits (visits with no laboratories, imaging, procedures, or admission), (2) ≥2 or ≥3 ED visits, and (3) admission.

RESULTS
We analyzed 6 810 864 ED visits by 3 999 880 children. LRI visits were more likely among children from very low compared with very high COI (1 LRI visit: odds ratio [OR] 1.35 [1.17–1.56]; ≥2 LRI visits: OR 1.97 [1.66–2.33]; ≥3 LRI visits: OR 2.4 [1.71–3.39]). ED utilization was more likely among children from very low compared with very high COI (≥2 ED visits: OR 1.73 [1.51–1.99]; ≥3 ED visits: OR 2.22 [1.69–2.91]). Risk of hospital admission from the ED was lower for children from very low compared with very high COI (OR 0.77 [0.65–0.99]).

CONCLUSIONS
Children from neighborhoods with low COI had higher ED utilization overall and more LRI visits, as well as visits more cost-effectively managed in primary care settings. Identifying neighborhood opportunity-related drivers can help us design interventions to optimize child health and decrease unnecessary ED utilization and costs.
Transitando desde las Fases de Cambio de Comportamiento hacia el Automanejo de Personas con Condiciones Crónicas.
Authors: Rimassa Carla , Lagos Maria Elena 
Published: September 2022

Introducción: A nivel mundial existe una constante preocupación debido a que cada día proliferan más personas con enfermedades crónicas. Para su abordaje, se han propuesto una serie de medidas que enfatizan el rol preponderante que tiene la persona en el logro del automanejo de su salud y enfermedad. El objetivo de este trabajo fue reflexionar acerca de elementos que favorecen el avance desde las etapas de cambio hacia el automanejo de personas con condiciones crónicas.
Desarrollo: Para lograr el automanejo, resulta trascendental considerar en la atención a la persona con enfermedades crónicas, entre otros aspectos, el proceso de cambio de comportamiento y el grado de autoeficacia percibida. Asimismo, el personal profesional de la atención primaria de salud y enfermería requieren desarrollar habilidades específicas y de alta idoneidad para una atención integral, oportuna y continuada. Todos estos aspectos se interrelacionan para converger juntos en un plan de atención de salud colaborativo, consensuado y centrado en la persona.
Conclusión: Para favorecer el avance del automanejo existen elementos tanto de la persona con enfermedad crónica como de la profesional que se articulan. Entre estas personas se dan relaciones de bidireccionalidad, que han de ser vistas como un proceso funcional continuo y no como elementos discretos en el cuidado en salud.
Nível de Conhecimento de Adolescentes Sobre a Infecção Pelo HIV: Uma Relação Com Autocuidado e Comportamentos de Risco.
Authors: Silva Natanias Macson da , Rego Thiago Luis de Holanda , Mendonça Letícia De Lima , Costa Mademerson Leandro da , Nascimento Ellany Gurgel Cosme Do , Maia Allyssandra Maria Lima Rodrigues 
Published: September 2022

Introdução: A adolescência é marcada por mudanças biopsicossociais e comportamentais, as quais são importantes para a construção da autonomia durante novas experiências. Porém, alguns hábitos nessa fase podem conferir riscos à infecção pelo HIV.
Objetivo: Avaliar práticas de adolescentes escolares que conferem risco à infecção pelo HIV, contrastando aspectos comportamentais com o nível de conhecimento prévio sobre esta infecção.
Métodos: Trata-se de um estudo transversal, com abordagens descritiva, quantitativa e correlacional com 273 adolescentes de instituições públicas de ensino situadas em seis municípios brasileiros. Os dados foram coletados através de dois questionários, com foco no autocuidado e no nível de conhecimento sobre anatomia, fisiopatologia e fatores de risco da infecção pelo HIV. Foram utilizadas medidas de frequência absoluta e relativa, bem como testes de correlação de Pearson (p valor < 0,05).
Resultados: Ocorreu maior representatividade dos adolescentes escolares com faixa etária entre 16 e 17 anos e sexo feminino. Os resultados mostram comportamentos de risco de exposição ao HIV, como atividade sexual precoce (38,4%), uso de drogas (21,8%), múltiplos parceiros sexuais (40,4%) e sexo desprotegido (54,5%), cenário que não esteve relacionado necessariamente com déficit de conhecimento. Ainda, o estudo aponta que quanto mais precoce a sexarca ou uso de drogas, maior o número de parceiros sexuais durante a adolescência, sugerindo alto risco de infecção pelo HIV. Acerca do uso de metodologias interativas, estas se apresentaram como potenciais ferramentas na educação permanente em saúde.
Conclusão: Constatou-se importantes comportamentos de risco referentes à infecção pelo HIV, por escolares, e que essas práticas não estão necessariamente ligadas ao déficit de conhecimento sobre este agravo. As implicações deste estudo são direcionadas ao fomento de mudanças em práticas de profissionais da saúde e educação, bem como desenvolvimento de políticas públicas que visem à redução do comportamento de risco pelos adolescentes.
Development of a farm-specific real-time quantitative RT-PCR assay for the detection and discrimination of wild-type porcine reproductive respiratory syndrome virus and the vaccine strain in a farm under eradication
Authors: Fornyos Kinga , Szabó István , Lebhardt Károly , Bálint Ádám 
Published: September 2022

Abstract
Porcine reproductive and respiratory syndrome (PRRS) is one of the most important diseases of swine causing severe economic losses worldwide, therefore intensive efforts are taken to eliminate PRRS virus (PRRSV) from infected herds for complete eradication. The most efficient, fastest but at the same time the most expensive eradication method is depopulation-repopulation. In order to reduce costs, a number of farms prefer to perform their eradication process with continuous production using modified live vaccine (MLV) immunisation. However, the commercial PRRSV RT-PCR kits do not have the capacity to discriminate infected from vaccinated animals. In this paper, we describe a simple discriminatory duplex TaqMan RT-PCR assay based on common forward and reverse primers, as well as two differently labelled MLV- and wild-type PRRSV-specific probes. The discriminatory PCR test we designed is a fast and efficacious method for processing large quantities of samples. The assay is cheap, flexible, easy to apply in different herds using different MLVs, but should be checked, and can be modified based on the sequence data obtained during the permanent monitoring examinations. Owing to its simplicity the test can serve as a significant complementary assay for PRRS control and elimination/eradication.
Identification of a Novel Mutation in the Cathepsin K (CTSK) Gene in Iranian Patients with Pycnodysostosis
Authors: Sarli Abdolazim , Sharbatkhori Sarina , Kowsari Ali 
Published: September 2022

Background: Pycnodysostosis is a rare autosomal recessive skeletal dysplasia, which is characterized by various skeletal malformations and distinctive facial characteristics. The disorder is caused by mutations in CTSK gene at chromosomal region 1q21, which encodes a lysosomal cysteine protease, cathepsin K.
Purpose: To describe the clinical, radiological, and molecular findings in a consanguineous Iranian family with 2 affected individuals demonstrating pycnodysostosis.
Methods: Whole exome sequencing (WES) was utilized to detect disease-causing variants. To prove the impact of the identified variants, in silico analysis using SIFT and PROVEAN web servers were carried out. The effects of the novel mutation on the protein structure was evaluated by Chimera software using normal and mutated structures derived from SWISS model web server.
Results: We identified the novel homozygous mutation, c.830C>A, in exon 7 of the CTSK gene. This missense mutation leads to the substitution of the amino acid alanine at position 277 by glutamic acid (p.A277E) in cathepsin K protease. Sanger sequencing analysis confirmed this mutation in the affected individuals and revealed that the parents were heterozygous for this gene mutation. Bioinformatics databases and the variant’s protein structure proved the deleterious effect of this novel mutation on the enzymatic activity of cathepsin K protease.
Peran Keluarga Dalam Pencegahan dan Penanggulangan Stunting Pada Masa Pandemi Covid-19 Di Desa Kauman RT 16 RW 08 Kecamatan Wiradesa Kabupaten Pekalongan
Authors: Priharwanti Ardiana , Amalia Riska 
Published: September 2022

Abstract. Pekalongan district was ranked 4th in Central Java as district with nutritional problems that have not been handled optimally. The result of weighing 10.316 children under five carried out in 2020 showed that 1.631 children under five were indicated stunting. Intervention activities in reducing stunting problem are carried out by team through 2 methods (offline and online) within a month from November 23 until December 23, 2021 in Kauman village. The offline method is carried out by “door to door” to avoid crowds and Focus Group Discussion (FGD) while still adhering to health protocols. Online activities are carried out through WhatsApp groups, Google Meet, and Youtube. Intervention activities has been done by 5 activities: 1) 3P+S: Placing Clean & Healthy Lifestyle and Stunting Posters, 2) 'EDULINTING' Stunting Mobile Education, 3) Movement for Parents to Understand Nutrition, Stunting Free Children, 4) CEMANGGI (Healthy and Nutritious Snack): Pumpkin Flavored Milk Pudding, and 5) FGD: DWM 'Discuss With Mom' with PARENTING theme. As a result of this activity, there has been a change in the behavior of the local community to become healthier in terms of eating patterns and increasing a clean and healthy lifestyle.
Keywords: Stunting, Pandemic, Family Role, Public Health

Abstrak. Kabupaten Pekalongan menduduki peringkat 4 se-Jawa Tengah sebagai kabupaten dengan permasalahan gizi yang belum tertangani secara optimal. Hasil penimbangan pada 10.316 balita pada 2020, tercatat 1.631 balita terindikasi stunting. Intervensi kegiatan dalam menurunkan permasalahan stunting dilakukan oleh tim pengabdian masyarakat melalui 2 metode yaitu luring dan daring dalam kurun waktu satu bulan yaitu pada 23 November sampai dengan 23 Desember 2021 di Desa Kauman RT 16 RW 08. Metode luring dilakukan secara door to door untuk menghindari kerumunan serta Focus Group Discussion (FGD) dengan penerapan protokol kesehatan. Kegiatan online dilakukan melalui grup WhatsApp, Google Meet, dan Youtube. Intervensi yang dilakukan terdiri dari 5 kegiatan: 1) 3P+S: Penempelan Poster PHBS dan Stunting, 2) Edukasi Keliling Stunting ‘EDULINTING’, 3) Gerakan Orang Tua Paham Gizi Anak Bebas Stunting, 4) CEMANGGI (Cemilan Sehat dan Bergizi): Puding Labu Kuning Fla Susu, dan 5) FGD: DWM ‘Discuss With Mom’ tentang PARENTING. Hasil dari kegiatan tersebut adalah terciptanya perubahan perilaku masyarakat setempat menjadi lebih sehat dari segi pola makan dan meningkatnya pola hidup bersih dan sehat.
Kata Kunci: Stunting, Pandemi, Kesehatan Masyarakat
Edukasi Gerakan 5M dan Gizi Seimbang di Masa Pembelajaran Tatap Muka pada Pelajar SMA Muhammadiyah 18
Authors: Muzakir Haris , Furqon Muhammad , Birwin Alib 
Published: September 2022

Abstract. The current Covid-19 pandemic has caused several sectors to experience difficulties in carrying out their activities. This also occurs in the education sector, where educators and students are limited in carrying out the learning process directly in the classroom. The risk of spreading can occur during face-to-face learning. PKM activities are carried out by providing counseling to tenth grade students of SMA Muhammadiyah 18 Jakarta regarding how to use masks, washing hands, maintaining distance, avoiding crowds and limiting mobility (5M) and balanced nutrition among students. Before counseling on the 5M program and balanced nutrition, tenth grade students of SMA Muhammadiyah 18 Jakarta did a pre-test. The pre-test was conducted to determine the students' initial knowledge about the 5M program and balanced nutrition. As a form of evaluation of PKM activities, a post-test was also conducted to determine the increase in knowledge from the material presented. The post-test results showed that participants experienced a good increase in knowledge, regarding social distancing by 70%, wearing masks by 74%, washing hands 84%, avoiding crowds by 89%, limiting mobility by 67% and balanced nutrition by 5%. The expected implication after holding this outreach is the students can implement measures to prevent the transmission of Covid-19, so that Covid-19 cases, especially among students, can be suppressed.
Keywords: Covid-19, 5M, Students

Abstrak. Pandemi Covid-19 saat ini menyebabkan beberapa sektor mengalami kesulitan dalam melakukan aktivitasnya. Hal ini terjadi juga pada sektor pendidikan, dimana pendidik dan pelajar menjadi terbatas dalam menyelenggarakan proses belajar secara langsung di kelas. Risiko penyebaran dapat terjadi pada saat pembelajaran tatap muka dan para pelajar belum mengetahui metode pencegahan covid-19. Kegiatan PKM dilakukan dengan memberikan penyuluhan kepada pelajar kelas sepuluh SMA Muhammadiyah 18 Jakarta terkait gerakan Menggunakan Masker, Mencuci Tangan, Menjaga Jarak, Menghindari Kerumunan dan Membatasi Mobilitas (5M) dan gizi seimbang dikalangan pelajar. Sebelum dilakukan penyuluhan gerakan 5M dan gizi seimbang, pelajar kelas sepuluh SMA Muhammadiyah 18 Jakarta mengerjakan terlebih dahulu pre-test. Pre-test dilakukan untuk mengetahui pengetahuan awal pelajar mengenai gerakan 5M dan gizi seimbang. Sebagai bentuk evaluasi kegiatan PKM, dilakukan juga post-test untuk mengetahui peningkatan pengetahuan dari materi yang disampaikan. Hasil post-test menunjukan peserta mengalami peningkatan pengetahuan yang baik, mengenai menjaga jarak sebesar 70%, memakai masker sebesar 74%, mencuci tangan 84%, menghindari kerumunan 89%, membatasi mobilitas sebesar 67% dan gizi seimbang sebesar 5%. Implikasi yang diharapkan setelah penyelenggaraan penyuluhan ini yaitu pelajar dapat menerapkan tindakan pencegahan penularan Covid-19, sehingga kasus Covid-19, khususnya dikalangan pelajar dapat ditekan.
Kata Kunci: Covid-19, 5M, Pelajar