bluuebunny/crossref_metadata_2025_split huggingface dataset:
Σταυρικές εγχαράξεις και απολάξευση γλυπτών κατά την Ύστερη Αρχαιότητα. Μία ερμηνευτική προσέγγιση
Authors: ΔΟΥΛΦΗΣ Ανδρέας 
Published: December 2022

Η σύγχρονη έρευνα υποδεικνύει μία περίπλοκη και - τουλάχιστον φαινομενικά - αντιφατική εικόνα ως προς τη στάση των Χριστιανών έναντι των μη χριστιανικών γλυπτών κατά την Ύστερη Αρχαιότητα. Σε ορισμένες περιπτώσεις, η ποιότητα της παρέμβασης υποδηλώνει καταστροφική πρόθεση για το αρχικό μήνυμα του γλυπτού καθώς και για την καλλιτεχνική του αξία. Σε άλλες περιπτώσεις, οι παρεμβάσεις γίνονται με προσοχή και προκαλούν μικρότερη ζημιά στην αρχική εικόνα. Το κύριο ερώτημα είναι: ποιοι είναι οι λόγοι για την εμφάνιση διαφορετικών πρακτικών; Ποιοι είναι οι λόγοι για την εκ νέου ερμηνεία των χριστιανικών αγαλμάτων σε χριστιανικό πλαίσιο σε μια σειρά υποθέσεων; Αντίθετα, ποιοι είναι οι λόγοι πίσω από τις περιπτώσεις όπου η καταστροφική πρόθεση εναντίον των γλυπτών είναι σαφής; Για να απαντηθεί πληρέστερα αυτή η ερώτηση επιχειρείται μια νέα ερμηνεία, σχετικά με την παράλληλη εμφάνιση αυτών των δύο διαφορετικών πρακτικών.
A review of existing neonatal hyperbilirubinemia guidelines in Indonesia
Authors: Sampurna Mahendra Tri Arif , Liem Kian Djien , Pratama Danny Chandra , Oktaviana Novita , Putra Achmad Januar Er , Zakiyah Rahmi , Visuddho Visuddho , Etika Risa , Handayani Kartika Darma , Utomo Martono Tri , Angelica Dina , Ayuningtyas Wurry , Hendrarto Toto Wisnu , Rohsiswatmo Rinawati , Wandita Setya , Kaban Risma Karina , Ahmad Jordy Maulana 
Published: December 2022

Background: Neonatal hyperbilirubinemia is one of the most common conditions for neonate inpatients. Indonesia faces a major challenge in which different guidelines regarding the management of this condition were present. This study aimed to compare the existing guidelines regarding prevention, diagnosis, treatment and monitoring in order to create the best recommendation for a new hyperbilirubinemia guideline in Indonesia. Methods: Through an earlier survey regarding adherence to the neonatal hyperbilirubinemia guideline, we identified that three main guidelines are being used in Indonesia. These were developed by the Indonesian Pediatric Society (IPS), the Ministry of Health (MoH), and World Health Organization (WHO). In this study, we compared factors such as prevention, monitoring, methods for identifying, risk factors in the development of neonatal jaundice, risk factors that increase brain damage, and intervention treatment threshold in the existing guidelines to determine the best recommendations for a new guideline. Results: The MoH and WHO guidelines allow screening and treatment of hyperbilirubinemia based on visual examination (VE) only. Compared with the MoH and WHO guidelines, risk assessment is comprehensively discussed in the IPS guideline. The MoH guideline recommends further examination of an icteric baby to ensure that the mother has enough milk without measuring the bilirubin level. The MoH guideline recommends referring the baby when it looks yellow on the soles and palms. The WHO and IPS guidelines recommend combining VE with an objective measurement of transcutaneous or serum bilirubin. The threshold to begin phototherapy in the WHO guideline is lower than the IPS guideline while the exchange transfusion threshold in both guidelines are comparably equal. Conclusions: The MoH guideline is outdated. MoH and IPS guidelines are causing differences in approaches to the management hyperbilirubinemia. A new, uniform guideline is required.
Limiting adverse birth outcomes in resource-limited settings (LABOR): protocol of a prospective intrapartum cohort study
Authors: Adu-Amankwah Amanda , Bellad Mrutunjaya B. , Benson Aimee M. , Beyuo Titus K. , Bhandankar Manisha , Charanthimath Umesh , Chisembele Maureen , Cole Stephen R. , Dhaded Sangappa M. , Enweronu-Laryea Christabel , Freeman Bethany L. , Freeman Nikki L. B. , Goudar Shivaprasad S. , Jiang Xiaotong , Kasaro Margaret P. , Kosorok Michael R. , Luckett Daniel , Mbewe Felistas M. , Misra Sujata , Mutesu Kunda , Nuamah Mercy A. , Oppong Samuel A. , Patterson Jackie K. , Peterson Marc , Pokaprakarn Teeranan , Price Joan T. , Pujar Yeshita V. , Rouse Dwight J. , Sebastião Yuri V. , Spelke M. Bridget , Sperger John , Stringer Jeffrey S. A. , Tuuli Methodius G. , Valancius Michael , Vwalika Bellington ,   LABOR Study Group
Published: December 2022

Background: Each year, nearly 300,000 women and 5 million fetuses or neonates die during childbirth or shortly thereafter, a burden concentrated disproportionately in low- and middle-income countries. Identifying women and their fetuses at risk for intrapartum-related morbidity and death could facilitate early intervention. Methods: The Limiting Adverse Birth Outcomes in Resource-Limited Settings (LABOR) Study is a multi-country, prospective, observational cohort designed to exhaustively document the course and outcomes of labor, delivery, and the immediate postpartum period in settings where adverse outcomes are frequent. The study is conducted at four hospitals across three countries in Ghana, India, and Zambia. We will enroll approximately 12,000 women at presentation to the hospital for delivery and follow them and their fetuses/newborns throughout their labor and delivery course, postpartum hospitalization, and up to 42 days thereafter. The co-primary outcomes are composites of maternal (death, hemorrhage, hypertensive disorders, infection) and fetal/neonatal adverse events (death, encephalopathy, sepsis) that may be attributed to the intrapartum period. The study collects extensive physiologic data through the use of physiologic sensors and employs medical scribes to document examination findings, diagnoses, medications, and other interventions in real time. Discussion: The goal of this research is to produce a large, sharable dataset that can be used to build statistical algorithms to prospectively stratify parturients according to their risk of adverse outcomes. We anticipate this research will inform the development of new tools to reduce peripartum morbidity and mortality in low-resource settings.
Single nucleotide polymorphism (SNP) in the doublesex (dsx) gene splice sites and relevance for its alternative splicing in the malaria vector Anopheles gambiae
Authors: Djihinto Oswald , Saizonou Helga D.M. , Djogbenou Luc S. 
Published: December 2022

Background: Malaria burden continues to be significant in tropical regions, and conventional vector control methods are faced with challenges such as insecticide resistance. To overcome these challenges, additional vector control interventions are vital and include modern genetic approaches as well as classical methods like the sterile insect technique (SIT). In the major human malaria vector Anopheles gambiae, a candidate gene favourable for sterility induction is the doublesex (dsx) gene, involved in mosquitos’ somatic sexually dimorphic traits determination. However, the pathways that trigger the signal of dsx gene exon skipping alternative splicing mechanism in anopheline mosquitoes are not well characterized. This study aims to screen the An. gambiae dsx gene splice site sequences for single-nucleotide polymorphisms (SNPs) that could be critical to its alternative splicing. Methods: Variant annotation data from Ag1000G project phase 2 was analysed, in order to identify splice-relevant SNPs within acceptor and donor splice sites of the An. gambiae dsx gene (Agdsx). Results: SNPs were found in both donor and acceptor sites of the Agdsx. No splice-relevant SNPs were identified in the female-specific intron 4 acceptor site and the corresponding region in males. Two SNPs (rs48712947, rs48712962) were found in the female-specific donor site of exon 5. They were not specific to either males or females as the rs48712947 was found in female mosquitoes from Cameroon, and in both males and females from Burkina Faso. In the other splice sites, the intron 3 acceptor site carried the greatest abundance of SNPs. Conclusions: There were no gender association between the identified SNPs and the random distribution of these SNPs in mosquito populations. The SNPs in Agdsx splice sites are not critical for the alternative splicing. Other molecular mechanisms should be considered and investigated.
Ultrastructural organization of the respiratory part of the lungs in streptozotocin-induced diabetes
Authors: Zaiats Liubomyr , Fedorchenko Yuliya , Zukow Walery 
Published: December 2022

Background. Diabetes mellitus is a metabolic disease characterized by persistent hyperglycemia, the prevalence and incidence of which have dramatically increased worldwide. Our research aimed to study the dynamics of changes in the components of the respiratory part of the lungs in streptozotocin-induced diabetes. Materials and methods. The experiments were performed on 88 white male Wistar rats weighing 170-210 g. The animals were divided into three groups: 1 - intact (n=10); 2 - control (n=40); 3 - experimental (n=38) with a model of diabetes mellitus, which was reproduced by intraperitoneal injection of streptozotocin company "Sigma" (USA), diluted in 0.1 M citrate buffer with pH 4.5, at a rate of 60 mg/kg body weight. The control group of animals received an intraperitoneal injection with an equivalent dose of 0.1 M citrate buffer solution with a pH of 4.5.
Pulmonary tissue collection for electron microscopic examination was performed under thiopental anesthesia 14, 28, 42, and 70 days after streptozotocin injection. Pieces of lung tissue were fixed in 2.5% glutaraldehyde solution, followed by fixation in 1% osmium tetroxide solution. After dehydration, the material was poured into epon-araldite. Sections obtained on an ultramicrotome "Tesla BS-490" were studied in an electron microscope «PEM-125K». All studies were performed under sodium thiopental anesthesia at the rate of 60 mg/kg of body weight. Results. Our research showed that 14 days after the modeling of streptozotocin-induced diabetes, mainly reactive changes were observed in the components of the respiratory part of the lungs. With an increase in the duration of the study (28-70 days), changes of a dystrophic-destructive nature were noted in alveolocytes of types I and II, and endotheliocytes of hemocapillaries. At the same time, cells with increased functional activity were determined in the components of the respiratory part of the lungs. Conclusion. Streptozotocin-induced diabetes leads to violations of the ultrastructural organization of components of the respiratory part of the lungs. The nature and severity of structural changes in type I, II alveolocytes, and endotheliocytes of hemocapillaries depend on the duration of diabetes.
Bevel Modification Effect on Rectangular Patch for UWB Using Theory Characteristics Mode
Authors: Sabila Liya Yusrina , Damayanti Denti Agustina 
Published: December 2022

Ultra-wideband (UWB) is a communications technology that operates on frequencies between 3.1 and 10.6 GHz and has a wide bandwidth. This paper aims to look at the radiation characteristics of the structure using the Theory Characteristic Mode on a rectangular antenna with bevel modifications at the end of the patch. It can be seen from the active mode at the appropriate frequency to validate the antenna performance results. It was found that the proposed antenna has four operational modes in the antenna design before modification and seven active modes in the antenna design after modification. The antenna is made of FR-4 material with a thickness of 1.575 mm and a dielectric constant of 4.3. The bandwidth in the error measurement is around 7 GHz and a frequency range of 3.18 - 10.915 GHz with an S11 value of less than -10 and a VSWR value of less than 2.
Ultra-wideband (UWB) adalah teknologi komunikasi yang beroperasi pada frekuensi antara 3,1 dan 10,6 GHz dan memiliki bandwidth yang sangat lebar. Makalah ini bertujuan untuk melihat karakteristik struktur radiasi menggunakan Theory Characteristic Mode pada antena rectangular dengan modifikasi bevel diujung patch. Untuk validasi hasil performansi antena dapat dilihat dari mode aktif pada frekuensi yang sesuai. Ditemukan bahwa antena yang diusulkan memiliki 4 mode aktif pada desain antena sebelum modifikasi dan 7 mode aktif pada desain antena sesudah modifikasi.. Antena terbuat dari bahan FR-4 dengan ketebalan 1,575 mm dan konstanta dielektrik 4,3. Bandwidth yang dicapai pada pengukuran adalah disekitar 7 GHz dan rentang frekuensi 3,18 - 10,915 GHz dengan nilai S11 kurang dari -10 dan nilai VSWR kurang dari 2.
Low-cost scanning LIDAR architecture with a scalable frame rate for autonomous vehicles
Authors: Fink Maximilian , Schardt Michael , Baier Valentin , Wang Kun , Jakobi Martin , Koch Alexander W. 
Published: December 2022

Autonomous vehicles need accurate 3D perception with a decent frame rate and high angular resolution to detect obstacles reliably and avoid collisions. We developed a low-cost scanning multichannel light detection and ranging sensor architecture allowing scalable frame rates by adjusting the number of laser and detector pairs. Scanning is achieved by a pair of micro–electro–mechanical system (MEMS) mirrors. A control pattern for the MEMS mirrors to maximize the frame rate is presented. A built prototype based on the proposed architecture achieves a frame rate of 11.5 Hz, a field of view of

70

∘

×

30

∘

, and an angular resolution of 0.4°. The distance resolution is 6 cm. Reliable single-shot detection for low-reflective objects up to 19 m indoors and 11 m under direct sunlight exposure is achieved. A performance assessment based on the presented measurement system for recently available vertical-cavity surface-emitting laser arrays with power densities up to

1

k
W

/

m
m

2

shows promising improvement potential.
Dual-wavelength paired-pulse Tm:YAlO3/Ho:LuLiF4 laser at 1944 and 2066  nm
Authors: Hu Guanqu , Yan Shixiong , Liu Wancheng , Huang Qigui , Bai Bing , Liu Fengli , Zhang Xinlu , Li Li 
Published: December 2022

The dual-wavelength paired-pulse output of a compact self-

Q

-switched

T
m

:

Y
A
l
O

3

intra-cavity pumping

H
o

:

L
u
L
i
F

4

laser was first demonstrated
experimentally. By exploiting the self-

Q

-switching mechanism of

T
m

:

Y
A
l
O

3

and the gain-switching operation of

H
o

:

L
u
L
i
F

4

in a cavity, the dual-wavelength
paired pulses were robustly generated with the pulse energy of
29 µJ, pulse width of 2.5 µs at 1944 nm, pulse
energy of 31 µJ, and pulse width of 338 ns at
2066 nm. The maximum average output powers were obtained
simultaneously as high as 525 mW at 1944 nm and
323 mW at 2066 nm. The paired-pulse repetition frequency
can be pump-tunable in the range of 8–22 kHz. The temporal
delay in the paired pulses can be controllable from 9.5 to
2.9 µs with the pump power increasing from 15.2 to
18.4 W. The compact dual-wavelength paired-pulse laser near
2 µm has potential application in the differential absorption
lidar.
Cardio-selective versus non-selective β-blockers for cardiovascular events and mortality in long-term dialysis patients: A systematic review and meta-analysis
Authors: Tao Shaohua , Huang Junlin , Xiao Jie , Ke Guibao , Fu Ping 
Published: December 2022

Background
Trials in patients receiving dialysis have demonstrated that β-blockers reduce all-cause mortality and cardiovascular events. However, differences still exist within-class comparative effectiveness studies of the therapeutic benefits of β-blockers in dialysis patients.

Objective
The purpose of this systematic review is to examine whether cardiovascular events and all-cause mortality differed between dialysis patients receiving cardio-selective and non-selective agents.

Methods
A comprehensive search of relevant articles from the PubMed, EMBASE, Cochrane Central Register and ClinicalTrials.gov was performed up to September 4, 2022, we included adults receiving β-blockers to evaluate the effects of cardio-selective versus non-selective agents on mortality and cardiovascular events in the dialysis population. Hazard ratios (HRs) and 95% confidence intervals (CIs) were examined for the negative outcomes of cardiovascular events and death for any reason. The risk of bias in randomized controlled trials (RCTs) was assessed using Cochrane’s risk of bias tool and the risk of bias in observational studies was assessed using a table designed according to the ROBINS-I tool, the evidence grade was assessed using the GRADE guideline. For all-cause mortality and cardiovascular events, the RevMan software (version 5.3) was used to calculate pooled HRs with 95% CI. The heterogeneity (I2) in statistics was used to examine the degree of heterogeneity among studies.

Results
Four observational studies, including 58, 652 long-term dialysis patients, were included in the meta-analysis. Compared to dialysis patients who took non-selective β-blockers, who took cardio-selective β-blockers was probably associated with fewer cardiovascular events (hazard ratio [HR] = 0.85, 95% confidence interval [CI] = 0.81, 0.89, heterogeneity [I2] = 0%, three trials, 52,077 participants, moderate-quality evidence) and may have lower all-cause mortality (HR = 0.83, 95% CI = 0.69, 0.99, I2 = 91%, four trials, 54,115 participants, low-quality evidence).

Conclusions
This systematic review showed that cardio-selective β-blockers are probably associated with fewer cardiovascular events and may have lower all-cause mortality in long-term dialysis patients than non-selective β-blockers. The present study results need to be replicated using randomized controlled trials with longer observation durations.
Morphological reflection of highly purified chondroitin sulfate action in patients with decompensated form of knee osteoarthritis
Authors: Minasov T. B. , Lila A. M. , Nazarenko A. G. , Sarvilina I. V. , Zagorodniy N. V. 
Published: December 2022

Objective: to study the morphological reflection of the parenteral form of highly purified chondroitin sulfate (CS) action in patients with osteoarthritis (OA) of the knee joints (KJ) during total knee arthroplasty (TA).Patients and methods. An open, prospective, controlled, randomized study included 67 patients (24 men and 43 women aged 41—73 years) with stage III knee OA and grade 2 functional insufficiency. The 1st (control) group included 35 patients, the 2nd (main) group included 32 patients. At baseline of the study, all patients were taking non-steroidal anti-inflammatory drugs (NSAIDs) at a standard daily dose. Patients of the 2nd group 2 months before the TA of KJ, additionally received a parenteral form of CS (Honrogard®), intramuscularly every other day: the first 3 injections at a dose of 100 mg/day; and if tolerability was good starting from the 4th injection, at a dose of200 mg / day (course — 25 injections). The intensity of pain was assessed according to the visual analog scale, WOMAC index, functional status according to the KOOS (Knee and Osteoarthritis Outcome Score) scale and the Lequesne index, standard radiography and magnetic resonance imaging of the knee joint were performed with an assessment of the T2 relaxation time. TA KJ was carried out according to C. Ranawat method.Results and discussion. In contrast to patients who took only NSAIDs, in patients who received CS during 50 days within 2 months before surgery, there were signs of adaptive restructuring in all layers of the preserved volume of hyaline cartilage and a decrease in the synovial membrane inflammation at the time of TA of KJ.Conclusion. The obtained results allow us to recommend the use of the parenteral form of CS (Honrogard®) according to the described scheme within 2 months before the TA of KJ in order to improve the morphological characteristics of cartilage and synovial tissue in the joints of the contralateral lower limb, taking into account the increase in the load on it in the postoperative period.
Emotional landscape of politics
Authors: Rothert Agnieszka 
Published: December 2022

This paper offers an interdisciplinary perspective on the meaning of emotion in politics. Politics will be understood as a people’s ability to live together. The author is a ranging synthesis of social sciences, psychology, biology and neuroscience for better illustration of issues of populism and other forms of social engagement. The paper is in the form of bringing the topics of emotions as a compass of our common human behavioural political make-up. Using the landscape metaphor allows for exploring the complete divergence of human emotions, sunny peaks of empathy, altruism, trust and dark shadowed valleys of fear, anger and distrust. In this manner, some explanation for populist behaviour is given. Collecting various sources of data is offered to experiment with varied forms of narrative and finally to discuss the findings but also to articulate an “emotional” call to collective kindness.
A case of intra-vaginal intrauterine testicular torsion
Authors: Habib Murad , Amjad Muhammad Bin , Ahmed Mansoor 
Published: December 2022

Abstract

Objectives
Intrauterine testicular torsion is extremely rare and the exact cause remains largely unknown. It is the result of an ischemic insult intrauterine, which presents as either extra-vaginal or intravaginal testicular torsion. Urgent surgical exploration and fixating the contralateral testis is key in the management of this condition.

Case presentation
We present here the case of a two-day old neonate with in-born right scrotal swelling admitted at Children’s hospital. The patient was born at term via cesarean section at a private hospital. Upon arrival in the emergency department, he was well hydrated, pink at room temperature with good perfusion. Upon examination, the right testis was found to be enlarged, tense, non-tender visibly reddish with overlying skin excoriation. Trans-illumination was negative in right but positive in the contralateral testis. Both hernial orifices were normal. Doppler ultrasound of the inguinoscrotal area found the right testis to be enlarged (15.6*9.4 mm) and showed heterogeneous hypoechoic texture with prominent rete testis and no flow on color doppler analysis. An urgent scrotal exploration was undertaken. Intra-operatively there was frank necrotic right testis with intravaginal torsion of the testis and minimal hydrocele. A right orchidectomy and contralateral orchidopexy were performed.

Conclusions
Intrauterine testicular torsion should be treated as a surgical emergency. We advocate early recognition of intrauterine testicular torsion, alongside surgical exploration and simultaneous contralateral orchidopexy.
Comparison of human PEX knockout cell lines suggests a dual role of PEX1 in peroxisome biogenesis
Authors: Ott Julia , Sehr Jessica , Schmidt Nadine , Schliebs Wolfgang , Erdmann Ralf 
Published: December 2022

Abstract
For the biogenesis and maintenance of peroxisomes several proteins, called peroxins, are essential. Malfunctions of these proteins lead to severe diseases summarized as peroxisome biogenesis disorders. The different genetic background of patient-derived cell lines and the residual expression of mutated PEX genes impede analysis of the whole spectrum of cellular functions of affected peroxins. To overcome these difficulties, we have generated a selected PEX knockout resource of HEK T-REx293 cells using the CRISPR/Cas9 technique. Comparative analyses of whole cell lysates revealed PEX-KO specific alterations in the steady-state level of peroxins and variations in the import efficacy of matrix proteins with a Type 2 peroxisomal targeting signal. One of the observed differences concerned PEX1 as in the complete absence of the protein, the number of peroxisomal ghosts is significantly increased. Upon expression of PEX1, import competence and abundance of peroxisomes was adjusted to the level of normal HEK cells. In contrast, expression of an alternatively spliced PEX1 isoform lacking 321 amino acids of the N-terminal region failed to rescue the peroxisomal import defects but reduced the number of peroxisomal vesicles. All in all, the data suggest a novel ‘moonlighting’ function of human PEX1 in the regulation of pre-peroxisomal vesicles.