bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curcumin and Curcumin-Loaded Nanogel Induce Apoptosis Activity in K562 Chronic Myelogenous Leukemia Cells
Authors: Khatamsaz Sepideh , Hashemi Mehrdad 
Published: January 2022

Background: Chronic myeloid leukemia (CML), a hematological cancer of stem cells, is caused by the activation of oncogenic factors alone or/with inactivation of tumor suppressor genes. Curcumin is a hydrophobic polyphenol and the main compound of turmeric, which has been used in daily diets for many years. It is also a safe drug. Nanogels and nanobiotechnology have important roles in the diagnosis and treatment of diseases and drug delivery. Materials and Methods: To prepare the nanodrug, chitosan nanogels were prepared in 1% acetic acid and cross-linked with stearate by 1- ethyl- 3 (3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS). Subsequently, curcumin was loaded in the chitosan-stearate nanogel. Physical and morphological characteristics of the nanodrug were determined by transmission electron microscopy (TEM), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy. Different nanodrug concentrations were prepared and evaluated on the K562 CML cell line. The apoptotic activities of curcumin and nanodrug on the cells were detected by flow cytometry, MTT assay, and trypan blue staining. Results: DLS revealed that the size of the nanodrug was 150 nm, which was confirmed by TEM. The half maximal inhibitory concentration (IC50) values of curcumin and nanodrug were 50 and 25 μg/ml, respectively P < 0.05). Apoptosis of the K562 cell line occurred at 48 h post-treatment with 25 μg/ml curcumin and 12.5 μg/ml nanodrug. Conclusion: The increase in the cytotoxicity of curcumin and nanodrug was directly related to the drug concentration and time. The nanodrug exhibited more cytotoxic effects on the vital capacity of the cells and stimulated more apoptosis compared with curcumin alone. [GMJ.2018;7:e921]
Персоналізація лікування хвороби Грейвса на підставі клініко- імунологічних характеристик перебігу захворювання
Authors: Buldygina Yu.V. , Shlyakhtych S.L. , Terekhova H.M. , Fed’ko T.V. , Klochkova V.M. , Strafun L.S. , Lysova Z.H. , Savos’ko I.I. 
Published: January 2022

Мета — удосконалення алгоритму лікування хвороби Грейвса (ХГ) на основі клініко-імунологічних особливостей перебігу захворювання. У дослідженні взяли участь 346 хворих на тиреотоксикоз. Вивчено показники 310 хворих на ХГ (272 жінки і 38 чоловіків), які були розподілені на дві групи: одну групу становили 126 осіб із ХГ і автоімунною офтальмопатією (АО), другу групу — 184 особи з ХГ без АО. Як контроль використали показники 36 хворих на токсичну аденому (ТА) жіночої статі аналогічного віку. Вік хворих коливався від 18 до 72 років (середній вік хворих на ХГ становив 46,4±2,7 року, хворих на ТА — 48,3±3,4 року). Матеріал і методи. Визначення тиреотропного гормону (ТТГ), вільного тироксину (ВТ4), вільного трийодтироніну (ВТ3) та антитіл до рецепторів тиреотропного гормону (АТ рТТГ) здійснювали методом хемілюмінесцентного імуноаналізу. Діагноз «автоімунна офтальмопатія» виставлено за даними клінічної картини, УЗД орбіт, екзофтальмометрії та висновку лікаря-офтальмолога. Статистичний аналіз отриманих результатів здійснювали за методом варіаційної статистики з обчисленням t-критерію Стьюдента; середні значення представлені як M±m; відмінності вважали вірогідними за p<0,05. Результати. У хвoрих на ХГ рівні АТ рТТГ дo пoчатку лікування були очікувано вищими за пoказники хворих на ТА (контрольна група), вірогідно (p<0,05) знижувались тільки чeрeз 6 міс. після пoчатку антитирeoїднoї тeрапії, і ця тeндeнція збeрігалась чeрeз 12 місяців. У хворих на ТА oчікуванo нe спoстeрігалoся збільшeння рівнів АТ рТТГ. У хвoрих із рецидивами тиреотоксикозу при антитиреоїдній терапії рівні АТ рТТГ були вірoгіднo вищими як на пoчатку, так і чeрeз 6 місяців лікування (24,27±2,86 МОд/л, 17,22±3,37 МОд/л, p<0,05), порівняно з хворими бeз рeцидивуючoгo пeрeбігу (12,28±3,57 МОд/л; 4,13±1,05 МОд/л, p<0,05). У хвoрих із рeмісією захвoрювання рівeнь АТ рТТГ чeрeз 6 міс. після тeрапії дoсягав мінімальних рівнів — 4,13±1,05 МОд/л, алe при цьoму пeрeвищував рeфeрeнтні лабoратoрні значeння (1,75 МОд/л), щo нe впливалo на стійкість рeмісії ХГ. Висновки. 1. Загальнoприйнятe мeдикамeнтoзнe лікування ХГ нeoбхіднo дoпoвнити oбoв’язкoвим мoнітoрингoм АТ рТТГ чeрeз 6 та 12 міс. після пoчатку тирeoстатичнoї тeрапії. 2. Оскільки вірoгіднe знижeння рівня АТ рТТГ відбувається тільки чeрeз 6 місяців після пoчатку тeрапії, його кoнтрoль у більш ранні стрoки є нeінфoрмативним і, відповідно, нeдoцільним. 3. Чeрeз 12 місяців після лікування мoжна спрoгнoзувати пoдальший пeрeбіг захвoрювання на oснoві значeнь АТ рТТГ: рівень АТ рТТГ ≤4,13 МОд/л мoжe свідчити прo імунoлoгічну рeмісію ХГ, а рівень АТ рТТГ ≥17 МОд/л після дoвгoтривалoї антитирeoїднoї тeрапії є прeдиктoрoм рoзвитку рeцидиву захвoрювання і, у такoму випадку, доцільно прoвoдити радикальне лікування хворих (хірургічне втручання чи радіойодтерапію).
KONSEP PENCAHAYAAN ALAMI PADA DESAIN RUANG GALERI MENGGUNAKAN DIALUX EVO 9.2 (Studi Kasus: Desain Perancangan Gedung Pusat Pertunjukan Seni Dan Budaya di Taman Mini Indonesia Indah, Jakarta Timur)
Authors: Pratiwi Fenny Kartika , Kridarso Etty R. , Iskandar Julindiani 
Published: January 2022

Abstract: The Gallery in the design of the Center for the Performing Arts and Culture has a function as an art exhibition using natural or artificial lighting by having standard of light intensity based on the Indonesian National Standard 03-6575-2001 Light Strength in the Gallery is 500 Lux and Greenship Rating Tools from Green Building Council Indonesia (GBCI), the minimum standard for natural lighting areas is 30% of the total area. The purpose of this research was to determine the design of the gallery according to the standards based on the simulation results using these standards as a reference for assessment identification. Writing with quantitative methods using DIALux Evo 9.2 software for building simulation by adjusting the coordinates of the building location, 3D building, and the effective hours from the sun source in the morning (06.00 WIB & 08.00 WIB), afternoon (12.00 WIB & 14.00 WIB), and evening (16.00 WIB). The simulation results contains lux calculations, lighting contours, and lighting distribution. Based on the analysis, the gallery has complied the standard of natural lighting needs around 08.00 WIB to 16.00 WIB and the distribution of lighting is 42-76% based on factors in the form of size, shape, dimensions of light openings, and building orientation. The results are used as the basis for the layout of the exhibition and artificial lighting points.Keyword: Gallery, Natural Lighting, DIALux Evo 9.2 Abstrak: Ruang Galeri pada desain Gedung Pusat Pertunjukan Seni dan Budaya memiliki fungsi sebagai ruang pameran karya seni dengan memanfaatkan pencahayaan alami ataupun buatan dengan standar kuat intensitas cahaya berdasarkan Standar Nasional Indonesia 03-6575-2001 Kuat Cahaya dalam Ruang Galeri yaitu 500 Lux dan Greenship Rating Tools dari Green Building Council Indonesia (GBCI) yaitu standar minimal untuk area pencahayaan alami adalah 30% dari total area. Tujuan penelitian ini untuk mengetahui desain ruang galeri sesuai standar berdasarkan hasil simulasi menggunakan standar tersebut sebagai acuan identifikasi penilaian. Penulisan dengan metode kuantitatif menggunakan perangkat lunak untuk simulasi bangunan yaitu DIALux Evo 9.2 dengan mengatur koordinat lokasi bangunan, 3D bangunan, dan jam efektif pencahayaan dari sumber matahari yaitu pagi hari (06.00 WIB & 08.00 WIB), siang hari (12.00 WIB & 14.00 WIB), dan sore hari (16.00 WIB). Data hasil simulasi berupa perhitungan lux, kontur penerangan, dan distribusi pencahayaan. Berdasarkan hasil analisis perangkat lunak, ruang galeri sudah memenuhi standar yaitu sekitar pukul 08.00 WIB hingga 16.00 WIB dan pesebaran pencahayaan 42-76% berdasarkan faktor ukuran, bentuk, dimensi bukaan cahaya pada ruangan, dan orientasi bangunan. Hasil analisis digunakan sebagai dasar tata letak pameran dan titik pencahayaan buatan.Kata Kunci: Ruang Galeri, Pencahayaan Alami, DIALux Evo 9.2
Smart Irrigation Controllers: Operation of Evapotranspiration-Based Controllers
Authors: Dukes Michael D. , Shedd Mary L. , Davis Stacia L. 
Published: January 2022

AE446, a 5-page illustrated fact sheet by Michael D. Dukes, Mary L. Shedd, and Stacia L. Davis, is part of the Smart Irrigation Controllers series. It presents the operational techniques of several commercially available evapotranspiration (ET) controllers that are being studied at the University of Florida. Includes references. Published by the UF Department of Agricultural and Biological Engineering, February 2009.
AE446/AE446: Smart Irrigation Controllers: Operation of Evapotranspiration-Based Controllers (ufl.edu)
Cassia afrofistula, Kenyan Cassia
Authors: Andreu Michael G. , Friedman Melissa H. , Northrop Robert J. 
Published: January 2022

Cassia afrofistula, Kenyan Cassia (FOR296/FR364)
The Kenyan cassia can be used as a showy ornamental tree or shrub, with its dark foliage and bright yellow flowers. Some people find the seed pods to be unattractive and prune the tree after it flowers to prevent pods from developing. This tree tolerates a wide range of soil types and can be used in a garden, park, patio, or streetscape setting. This 2-page fact sheet was written by Michael G. Andreu, Melissa H. Friedman, and Robert J. Northrop, and published by the UF Department of School of Forest Resources and Conservation, July 2012.
http://edis.ifas.ufl.edu/fr364
Fortunella spp., Kumquat
Authors: Andreu Michael G. , Friedman Melissa H. , Northrop Robert J. 
Published: January 2022

Fortunella spp., Kumquat (FOR300/FR368)
Many people find kumquat trees attractive and useful yard specimens. Their dark green leaves and contrasting bright orange fruits give them ornamental quality, and their relatively small size makes them easy to care for once they’re established. Because kumquats generally require less care than other citrus trees, they may be a good choice for gardeners with less time or experience, but who still desire an attractive and tasty citrus tree. If space is an issue, kumquats also do well in containers as long as they receive proper sunlight and watering. This 2-page fact sheet was written by Michael G. Andreu, Melissa H. Friedman, and Robert J. Northrop, and published by the UF Department of School of Forest Resources and Conservation, July 2012.
http://edis.ifas.ufl.edu/fr368
How to Clean Up Mold
Authors: Lee Hyun-Jeong 
Published: January 2022

FCS-3301, a 3-page illustrated fact sheet by Hyun-Jeong Lee, provides homeowners with basic guidance on assessing a mold problem, preparing for cleanup, and removal procedures, with links to other EDIS fact sheets for more detailed information. Includes references. Published by the UF Department of Family Youth and Community Sciences, January 2009.
Effect of main cultivation methods in dry rainfed conditions on the amount of weed under winter wheat
Authors: Feyzullayev H. M. 
Published: January 2022

Relevance. Against the background of predecessors, soil cultivation and nutritional conditions, weeding of the area under Barakatli 95 durum wheat variety was studied and the results obtained are given in the article. Thus, high weeds in the field reduce the quantity and quality of crops. One of the main factors preventing this is the application of proper cultivation methods appropriate to the region. This is one of the most important and urgent issues in agriculture.Methodology. The research was conducted in a 3-factor (2×3×3) field experiment in a short-rotation crop rotation (pea-wheat-wheat) located at the Jalilabad Regional Experimental Station in the rainfed conditions of South Mugan. The amount of weeds in the field was studied in the first decade of March and April by counting weeds per 1 m2 from different parts of the field according to the options.Results. The results of the 3-year study (average for 2019–2021) showed that the effect of predecessors, soil cultivation and nutritional conditions on the amount of weeds under winter wheat was different. Among the cultivation options, relatively high weeding soil was obtained with a heavy disc harrow at a depth of 10–12 cm in the form of 1 disc, and against the background of feeding conditions, N60P60 + 10 tons of manure on all three cultivations, and the least weeding was observed in the variant where N90P60K45 fertilizer norm was applied in 2 discs at a depth of 10–12 cm with a heavy disk trowel after the pea predecessor.
New technological solutions for restoring the inner surface of hydraulic cylinders
Authors: Chavdarov A. V. , Tolkachev A. A. 
Published: January 2022

Relevance. Agricultural machines widely use hydraulic cylinders for various auxiliary and working movements. Operation in harsh field conditions leads to the failure of the hydraulic cylinder mirror and, as a result, to the loss of force on the cylinder rod. The development of technological solutions for the restoration of the inner surface as a more appropriate solution in repair production is relevant.Methods. Studies of the heat flow using the “Fluke Ti32” thermal imager and ofthe influence of gas-dynamic spraying (GDS) modes on the adhesive and cohesive strength when using a new design of the nozzle part of the GDS equipment were carried out.Results. The suitability of usage of new nozzle design for GDS in order to restore the inner surface of the hydraulic cylinder body has been established. The elongated and curved nozzle for installations of the “Dimet” type practically does not change the temperature regime of spraying. The adhesive and cohesive strength of the coatings obtained with the new nozzle design is sufficient to operate under conditions characteristic of the inner surface of the hydraulic cylinder body.
Assessment of the degree of lameness in cows
Authors: Kontsevaya S. Yu. , Nefedov A. M. , Lutsay V. I. , Lavrov S. I. , Pekurovsky D. A. 
Published: January 2022

Relevance. The structure of the hoof of cows is a complex biological mechanism consisting of the hoof joint, hoof bone, finger pad, sole, hoof wall, etc. According to V.A. Lukyanovsky (1982), hooves are an additional heart of the animal, since when the hoof hits the ground, the blood actively rises, which allows to create auxiliary pressure in the blood vessels, facilitating the work of the heart muscle. When this system is violated, pathologies of the cardiovascular system often develop. The appearance of foci of the pathological process in different parts of the hoof will not only disrupt the work of the heart, but also cause discomfort, pain, and most importantly — lameness, which will be the driving force in a significant decrease in the productivity of cattle.Methods. Scientists identify three main signs of developing lameness in an animal. The first is the position of the back when walking, normally the back should be smooth and straight, while with the onset of lameness, the animal will carefully rearrange the limb, thereby straining the dorsal muscles, after which a bend in the back will be observed. The second sign is a short step, since with pain syndrome, the animal tries to minimize the load on the diseased limb. The third sign will be the obvious protection of the diseased limb, as a result of which the animal will completely cease to rely on the limb, both when walking and when standing.Results. A systematic approach will allow us to present a mathematical model of a healthy animal and of lame one. Thus, the following pattern can be identified: In order to receive nutrients together with the feed, the cow must reach the feeder, therefore, depending on the degree of lameness, there is a decrease in the consumption of dry matter, up to 15%. Based on this, it can be calculated that with a lack of nutrients and energy, there will be a decrease in milk yield of up to 36%. Which, according to P.I. Nikanorov and I.M. Kasyanov, will lead to a loss of up to 300 kg of milk for the entire lactation period. It was found that in the presence of overgrown and deformed hooves, the daily milk yield of cows is reduced by 5–12%, and with the appearance of cracks in the fragments of the horny capsule — by 19–20%. Also, the birth of a calf is required to obtain milk, and the presence of lameness will negatively affect the production of reproductive hormones, lead to the appearance of “quiet” hunting, which in turn will indirectly lead to a loss of milk productivity.
Digital Image Segmentation Resulting from X-Rays of Covid Patients using K-Means and Extraction Features Method
Authors: Dhian Satria Yudha Kartika  , Anita Wulansari  , Hendra Maulana  , Eristya Maya Safitri  , Faisal Muttaqin  
Published: January 2022

The COVID-19 pandemic has significant impact on people's lives such as economic, social, psychological and health conditions. The health sector, which is spearheading the handling of the outbreak, has conducted a lot of research and trials related to COVID-19. Coughing is a common symptoms among humans affected by COVID-19 in earlier stage. The first step when a patient shows symptoms of COVID-19 was to conduct a chest x-ray imaging. The chest x-rayss can be used as a digital image dataset for analysing the spread of the virus that enters the lungs or respiratory tract. In this study, 864 x-rays were used as datasets. The images were still raw, taken directly from Covid-19 patients, so there were still a lot of noise. The process to remove unnecessary images would be carried out in the pre-processing stage. The images used as datasets were not mixed with the background which can reduce the value at the next stage. All datasets were made to have a uniform size and pixels to obtain a standard quality and size in order to support the next stage, namely segmentation. The segmentation stage of the x-ray datasets of Covid-19 patients was carried out using the k-means method and feature extraction. The Confusion Matrix method used as testing process. The accuracy value was 78.5%. The results of this testing process were 78.5% of precision value, 78% of recall and 79% for f-measure
KEKERASAN TERHADAP ANAK PADA MASA PANDEMI COVID-19
Authors: Sakroni Sakroni 
Published: January 2022

Selama pandemi COVID-19 angka kekerasan terhadap anak di Indonesia terus meningkat. Tulisan ini merupakan kajian literatur yang bertujuan untuk mengkaji faktor penyebab terjadinya kekerasan terhadap anak pada masa pandemi COVID-19 dan upaya pencegahannya. Analisis dalam tulisan ini dilakukan melalui kajian pustaka. Secara umum faktor penyebab kekerasan terhadap anak pada masa pandemi COVID-19 terjadi karena adanya tekanan ekonomi akibat adanya pembatasan aktivitas di ruang publik pada masa pandemi, ketidakseimbangan hubungan anak dan orang tua,Â dan rendahnya pengetahuan orang tua dalam pola pengasuhan anak. Gambaran kasus kekerasan terhadap anak yang diangkat dalam tulisan ini adalah kekerasan yang dilakukan ibu saat mendampingi anak belajar di rumah. Dampak jangka pendek dari kekerasan adalah mempengaruhi fisik korban, sedangkan dampak jangka panjang berkaitan dengan psikis korban. Pelindungan hukum terhadap anak korban kekerasan adalah Undang-Undang No.35 Tahn 2014 tentang Perlindungan anak. Mengatasi kekerasana terhadap anak pada masa pandemi COVID-19 harus diusahakan dalam lingkungan bermasyarakat melalui berbagai upaya pencegahan. Dalam tulisan ini penulis menyarakan agar perlu adanya kesadaran bersama, bahwa tindak kekerasan sudah merupakan kejahatan yang sangat luar biasa yang dapat mengganggu tumbuh kembang anak di masa yang akan datang.
SOCIAL ENTREPRENEURSHIP DAN CORPORATE SHARED VALUE UNTUK PEMBERDAYAAN PETERNAK SAPI PERAH
Authors: Teguh Monika , Sitepu Sri Nathasya Br , Wiwiek Wiwiek , Tanaka Priscylia 
Published: January 2022

Peternakan sapi merupakan salah satu sub-sektor yang berperan penting bagi masyarakat Indonesia. Selain karena usaha peternakan sapi mendorong perekonomian masyarakat di wilayah-wilayah pedesaan, peternakan sapi juga penting dalam menjaga ketahanan pangan nasional. Sayangnya masih banyak peternak sapi rakyat yang hidup pra-sejahtera. Maka dari itu diusung dua buah konsep yang saling berkesinambungan untuk mengatasi permasalahan para peternak sapi rakyat. Konsep pertama adalah social entrepreneurship Â di mana para peternak dapat membentuk suatu social entreprise bersama untuk meningkatkan daya saing mereka di pasar. Dengan konsep ini, para peternak rakyat dapat menyatukan sumber daya yang mereka miliki dalam satu organisasi yang terstruktur dan memiliki legalitas yang lebih kuat. Jika dalam membentuk social entreprise ini para peternak mengalami kesulitan modal, maka mereka dapat menggunakan konsep kedua yaitu creating shared value (CSV). CSV merupakan konsep di mana perusahaan yang bermodal kuat bergandengan dengan social entreprise, bukan hanya untuk mendukung social entreprise itu, namun juga untuk berbagi nilai yang saling menguntungkan. Dengan adanya kerjasama jenis ini, social entreprise dapat berkembang tanpa ketakutan akan kurangnya modal, sedangkan perusahaan pemodal bisa memperoleh keuntungan seperti pasokan bahan baku, pembagian keuntungan, maupun peluang usaha baru. Konsep-konsep ini telah dilaksanakan di negara berkembang lain seperti India dan memberikan dampak positif. Maka dari itu diharapkan konsep-konsep ini juga dapat dijalankan di berbagai wilayah di Indonesia dengan dorongan dari pemerintah, institusi pendidikan, maupun organisasi nirlaba.
Soil-Transmitted Helminthiasis, Nutritional Status, and Hemoglobin Levels of School-Age Children in Makassar
Authors: Fattah Nurfachanti , Nurmadilla Nesyana , Irmayanti Irmayanti , Safitri Asrini 
Published: January 2022

Introduction: Soil-transmitted helminthiasis (STH) is common in areas with poor sanitation. In Indonesia, the prevalence of the disease is still high ranging from 16–72%, despite the elimination efforts that have been done. This study aimed to determine the prevalence of STH, nutritional status, and hemoglobin levels of elementary school-age children in of slum area in Makassar.
Methods: This was an observational study with a cross-sectional approach. Subjects were 33 elementary school-age children in one of the slum areas in Makassar, South Sulawesi, Indonesia. Stool samples were collected and examined using the Kato-Katz method. Hemoglobin levels were examined with the Azidemet hemoglobin method using capillary blood samples. Assessment of nutritional status was carried out anthropometrically using weight for height, height for age, and body mass index (BMI) for age as indicators.

Results: The prevalence of STH in this study was 27%, all of them had low nutritional status. As many as 15% and 45% of subjects were severely wasted and wasted, respectively, based on the weight for height indication, 61% were wasted based on the BMI for age indicator, and 12% were stunted based on the height for age indicator. Ten percent of the subjects had low hemoglobin levels, none of them had STH.
Conclusion: The STH prevalence of school-age children in one of the slum areas in Makassar is still high. Subjects with STH also experienced low nutritional status.