bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blimp1 suppressed CD4+ T cells‐induced activation of fibroblast‐like synoviocytes by upregulating IL‐10 via the rho pathway
Authors: Meng Qingliang , Wen Zhike , Meng Wanting , Bian Hua , Gu Huimin , Zuo Ruiting , Zhan Junping , Wang Huilian , Miao Xiyun , Fan Wei , Zhou Zipeng , Zheng Fuzeng , Wang Liying , Su Xiao , Ma Junfu 
Published: October 2022

AbstractBackgroundB lymphocyte‐induced maturation protein 1 (Blimp1) is a risk allele for rheumatoid arthritis (RA), but its functional mechanism in RA remains to be further explored.MethodsFlow cytometry was performed to detect CD4+ T cell differentiation. ELISA was used to measure inflammatory factor secretion. Lentivirus mediated Blimp1 overexpression vector (LV‐Blimp1) or short hairpin RNA (sh‐Blimp1) were used to infect CD4+ T cells stimulated by anti‐CD28 and anti‐CD3 mAbs. RA fibroblast‐like synoviocytes (FLSs) were co‐cultured with CD4+ T cells or T cell conditioned medium (CD4CM), and cell proliferation, invasion, and expression of adhesion molecules and cytokines in FLSs were evaluated. Mice were injected intradermally with type II collagen to establish a collagen‐induced arthritis (CIA) mouse model, and the severity of CIA was evaluated with H&E and Safranin‐O staining.ResultsBlimp1 knockdown increased pro‐inflammatory factor secretion, but downregulated IL‐10 concentration in activated CD4+ T cells. Blimp1 overexpression promoted regulatory T cells (Treg) CD4+ T cell differentiation and hindered T helper 1 (Th1) and T helper 17 (Th17) CD4+ T cell differentiation. Blimp1 overexpression suppressed the expression of pro‐inflammatory factors and adhesion molecules in CD4+ T cells by upregulating IL‐10. Moreover, Blimp1 overexpression impeded the enhanced effect of CD4+ T cells/CD4CM on cell adhesion, inflammation, proliferation, invasion and RhoA and Rac1 activities in FLSs by upregulating IL‐10. Additionally, administration with LV‐Blimp1 alleviated the severity of CIA.ConclusionBlimp1 restrained CD4+ T cells‐induced activation of FLSs by promoting the secretion of IL‐10 in CD4+ T cells via the Rho signaling pathway.
Clinical utility of serum fructosamine in long‐term monitoring of diabetes mellitus in dogs
Authors: Kuzi Sharon , Mazaki‐Tovi Michal , Ahmad Wiessam Abu , Ovadia Yael , Aroch Itamar 
Published: October 2022

AbstractBackgroundSerum fructosamine (sFA) is used to assess glycaemic control in dogs with diabetes mellitus (DM). Nevertheless, its interpretation is hindered by several limitations.MethodsThis retrospective study evaluates the long‐term diagnostic performance of sFA for monitoring clinical control of DM. sFA, bodyweight, appetite, presence of polyuria/polydipsia and clinical scores (CS; well‐controlled DM, CS‐0; uncontrolled DM, CS‐1) were recorded.ResultsThe study included 75 dogs (321 visits; median 3 visits/dog; range 1–19). Mean sFA was higher (p < 0.001) on visits with CS‐1 (584 μmol/L; 95% confidence interval [95% CI] 561–608) than on visits with CS‐0 (506 μmol/L; 95% CI 484–528). Increases in sFA increased the odds ratio for CS‐1 (1.37; 95% CI 1.24–1.52, p < 0.001). sFA was moderately predictive of the CS (area under receiver operating characteristic curve = 0.75; 95% CI 0.70–0.80; p < 0.0001), with a 486 μmol/L cutoff yielding 80% sensitivity and 59% specificity. Mean sFA was lower (p = 0.005) when hypoglycaemic episodes were suspected (496 μmol/L; 95% CI 450–541) than in their absence (572 μmol/L; 95% CI 548–596). sFA is moderately accurate for classifying CS in diabetic dogs. Decreasing sFA over follow‐ups indicates improved CS but might suggest occurrence of hypoglycaemic episodes.LimitationsRetrospective design, variable treatments and comorbidities are limitations of this study.ConclusionsFA has a moderate clinical utility in the long‐term monitoring of diabetic dogs, but may serve as a first‐line, accessible diagnostic tool. Discordant CS and sFA evaluation, or decreased sFA, warrants additional monitoring (i.e., continuous glucose monitoring).
Notes on resonances and unitarity from celestial amplitudes
Authors: García-Sepúlveda Diego , Guevara Alfredo , Kulp Justin , Wu Jingxiang 
Published: October 2022

Abstract
We study the celestial description of the O(N) sigma model in the large N limit as introduced by Coleman, Jackiw and Politzer. Focusing on three dimensions, we analyze the implications of a UV complete, all-loop order 4-point amplitude of pions in terms of correlation functions defined on the celestial circle. We find these retain many key features from the previously studied tree-level case, such as their relation to Generalized Free Field theories and crossing-symmetry, but also incorporate new properties such as IR/UV softness and S-matrix metastable states. In particular, to understand unitarity, we propose a form of the optical theorem that controls the imaginary part of the correlator based solely on the presence of these resonances. We also explicitly analyze the conformal block expansions and factorization of four-point functions into three-point functions. We find that summing over resonances is key for these factorization properties to hold. We end with some topics for future study.
Towards an “AdS1/CFT0” correspondence from the D(−1)/D7 system?
Authors: Aguilar-Gutierrez Sergio E. , Parmentier Klaas , Van Riet Thomas 
Published: October 2022

Abstract
We argue that a type IIB Euclidean supergravity solution of the form ℝ × S1× 𝕋8 with imaginary self-dual F1 flux through ℝ × S1 belongs to the chain of AdSd× Sd× 𝕋10−2d vacua with (imaginary) self-dual Fd flux, where d ≤ 5. Such vacua come from the near-horizon of D(d − 2)/D(8 − d) branes and are supersymmetric for odd values of d. For d = 1 we speculate that the hallmark of conformal symmetry for the matrix model dual is a vanishing free energy. The matrix dual was recently constructed by [1] by adding matrix interactions coming from strings stretching between the D(−1) and D7 branes to the IKKT matrix model. We find that the corresponding supergravity solution indeed has vanishing on-shell action. Specific F5 fluxes need to be switched on as a consequence of (a T-dual version of) the Hanany-Witten effect.
Bisphenol A: Potential Factor of Miscarriage in Women in the Context of the Phenomenon of Neutrophil Extracellular Traps
Authors: Omeljaniuk Wioleta Justyna , Charkiewicz Angelika Edyta , Garley Marzena , Ratajczak-Wrona Wioletta , Czerniecki Jan , Jabłońska Ewa , Cechowska-Pasko Marzanna , Miltyk Wojciech 
Published: October 2022

AbstractHumans are exposed to a number of environmental pollutants every day. Among them, endocrine disruptors are particularly harmful to human health. Bisphenol A (BPA) is a xenoestrogen that has been shown to disrupt the endocrine system and cause reproductive toxicity. In this study, we aimed to verify the potential relationship between BPA and miscarriage involving the formation of neutrophil extracellular traps (NETs). Blood samples were collected from healthy women and women who had miscarriage in the first trimester of pregnancy. The serum levels of cytoplasmic anti-PR3 antibody and perinuclear anti-MPO antibody were determined using an immunoenzymatic method. The concentrations of key proinflammatory proteins TNF-α and MCP-1, as well as NADPH oxidase subunits NOX1 and NCF2, were also measured in the serum samples. The serum concentration of BPA was determined using gas chromatography. The results showed that the concentrations of BPA were significantly elevated in the serum of women who had miscarriage compared to the control group, with the highest concentration found in the “NETs-positive” group. The levels of MCP-1 and TNF-α were significantly higher in the “NETs-positive” group compared to the “NETs-negative” and control group. The levels of NOX1 and NCF2 were also higher in the “NETs-positive” group compared to the “NETs-negative” group. The study showed that BPA could play a role in the course of miscarriage through the formation of NETs. The results indicate the need to limit the exposure of women planning pregnancy to xenoestrogens, including BPA.
The emergence of artificial intelligence in European regions: the role of a local ICT base
Authors: Xiao Jing , Boschma Ron 
Published: October 2022

AbstractThe purpose of this study is to investigate how a regional knowledge base of information and communication technologies (ICTs) influences the emergence of artificial intelligence (AI) technologies in European regions. Relying on patent data and studying the knowledge production of AI technologies in 233 European regions in the period from 1994 to 2017, our study reveals three results. First, ICTs are a major knowledge source of AI technologies, and their importance has been increasing over time. Second, a regional knowledge base of ICTs is highly relevant for regions to engage in AI inventing. Third, the effects of a regional knowledge base of ICTs are stronger for regions that have recently caught up regarding AI inventing. Our findings suggest that ICTs play a critically enabling role for regions to diversify into AI technologies, especially for regions’ catching up in terms of AI inventing.
Cut Locus on Compact Manifolds and Uniform Semiconcavity Estimates for a Variational Inequality
Authors: Générau François , Oudet Édouard , Velichkov Bozhidar 
Published: October 2022

AbstractWe study a family of gradient obstacle problems on a compact Riemannian manifold. We prove that the solutions of these free boundary problems are uniformly semiconcave and, as a consequence, we obtain some fine convergence results for the solutions and their free boundaries. More precisely, we show that the elastic and the $$\lambda $$
λ
-elastic sets of the solutions Hausdorff converge to the cut locus and the $$\lambda $$
λ
-cut locus of the manifold.
Stochastic Port-Hamiltonian Systems
Authors: Cordoni Francesco , Di Persio Luca , Muradore Riccardo 
Published: October 2022

AbstractIn the present work we formally extend the theory of port-Hamiltonian systems to include random perturbations. In particular, suitably choosing the space of flow and effort variables we will show how several elements coming from possibly different physical domains can be interconnected in order to describe a dynamic system perturbed by general continuous semimartingale. Relevant enough, the noise does not enter into the system solely as an external random perturbation, since each port is itself intrinsically stochastic. Coherently to the classical deterministic setting, we will show how such an approach extends existing literature of stochastic Hamiltonian systems on pseudo-Poisson and pre-symplectic manifolds. Moreover, we will prove that a power-preserving interconnection of stochastic port-Hamiltonian systems is a stochastic port-Hamiltonian system as well.
The iliac stemmed cup in reconstruction of the acetabular defects secondary to tumor resection: a systematic review of literature
Authors: Zoccali Carmine , Giannicola Giuseppe , Zoccali Giovanni , Checcucci Elisa , Scotto di Uccio Alessandra , Attala Dario , Villani Ciro 
Published: October 2022

Abstract
Introduction
Stemmed acetabular cups are suitable for reconstruction in case of important bone loss. Nevertheless, their use is not so common, because generally judged very invasive and technically difficult to implant. The aim of the present review is to verify the results of their use and to evaluate indications and complications.

Materials and methods
Literature research was performed in the main healthcare databases; indications, surgical technique, related complications, functional results and implant survival were valued and analyzed for every selected paper.

Results
13 studies were selected, for a population of 424 patients and 428 hips. The main indication was reconstruction after tumor removal; the primary non-oncologic indication was revision for aseptic loosening. The most frequent complications were aseptic loosening and implant failure (16.2%), followed by deep infection (11.3%) and dislocation (9.8%). The average MSTS score was 65.9%; while data regarding functional results for degenerative cases are quite fragmented. The 5-years implant survival was 73.6%.

Conclusions
Data regarding SAC prostheses are quite rare in the literature; no prospective studies with comparisons with other reconstruction techniques are available so their use is mainly based on the experience of single centers. While data for tumors are more consistent and supported by studies, information on revisions of hip prosthesis implanted for degenerative problems is quite scarce. Preliminary results on the SAC prosthesis as a valid alternative both for tumoral and degenerative revision cases are encouraging. Prospective randomized studies are advocated to value results compared to alternative techniques.
Laparoscopic surgery in 3D improves results and surgeon convenience in sleeve gastrectomy for morbid obesity
Authors: Martínez-Ubieto Fernando , Aragón-Benedí Cristian , Barranco-Dominguez Ignacio , Tardós-Ascaso Lucía , Jiménez-Bernadó Teresa , Pascual-Bellosta Ana , Ramírez-Rodriguez José Manuel , Martínez-Ubieto Javier ,   Research Group in Anesthesia, Resuscitation, Perioperative Medicine of Aragón Health Research Institute (IIS Aragón), Ortega-Lucea Sonia , Gil-Bona Jesús , Muñoz-Rodríguez Luis Alfonso , Pérez-Navarro Guillermo , Quesada-Gimeno Natividad , Perez-Otal Berta , Heredia-Coca Carmen , Ojeda-Cabrera Jorge Luis 
Published: October 2022

Abstract
Purpose
Advanced laparoscopic procedures are still challenging. One critical issue is the lack of stereoscopic vision. The aim of this surgical study is to evaluate whether 3D vision offers any advantages for surgical performance over 2D vision during sleeve gastrectomy for morbid obesity using a laparoscopic system that allows changing between 2D and 3D optics.

Methods
A total of 78 patients were analyzed, with 37 in the 2D group and 41 in the 3D group. Performance time, hospital stay, complications, and early outcomes were collected. To assess the quality of the 2D and 3D techniques, visual analog scales from 0 to 10 were designed, and image quality, depth of field, precision in performing tasks, and general ergonomics were measured.

Results
According to the vision system used, the mean duration of surgery was 85 ± 16.8 min for patients operated on with the 2D system and 69 ± 16.9 min for those operated on with the 3D system. There were no significant differences between the overall percentages of complications according to the type of vision used. However, postoperative complications were more severe in the 2D laparoscopy group. The average length of stay was shorter for patients in the 3D group. Regarding the differences perceived by the surgeon, the depth of field and the precision of tasks were better in the 3D vision group.

Conclusion
The 3D system provided greater depth perception and precision in more complex tasks, enabling safer surgery. This led to a reduction in the operative time and hospital stay. Moreover, the severity of complications was less.
Time reproduction, bisection and doubling: a novel paradigm to investigate the effect of the internal clock on time estimation
Authors: Momi Davide , Prete Giulia , Di Crosta Adolfo , La Malva Pasquale , Palumbo Rocco , Ceccato Irene , Bartolini Emanuela , Palumbo Riccardo , Mammarella Nicola , Fasolo Mirco , Di Domenico Alberto 
Published: October 2022

AbstractTime perception is not always veridical, but it can be modulated by changes in internal and external context. The most-acknowledged theory in this regard hypothesises the existence of an internal clock allowing us to subjectively estimate time intervals. The aim of the present study is to investigate the possible effect of such an internal clock, measured as the ability to reproduce a target duration, in the mental manipulation of time: 63 healthy participants were asked to Bisect and to Double reference time intervals, besides Reproducing them. Moreover, to investigate whether time processing might be predicted by individual differences, handedness, anxiety, and personality traits were also assessed by means of standardized questionnaires. Results show that participants correctly Reproduce time intervals (internal clock), but they overestimate time intervals during Bisection and underestimate them during Doubling. We explain this unexpected pattern of results as a kind of aftereffect, due to the short-term retention (adaptation) to the subjective representation of shorter (Bisection) vs longer (Doubling) intervals, respectively. Moreover, hierarchic regression models reveal that some personality traits can predict Bisection accuracy, but they clearly show that the best predictor for both Bisection and Doubling is the accuracy in Reproducing time intervals, confirming the fundamental role of the internal clock in time estimation. We conclude that time estimation is a unique skill, mostly independent from inter-individual differences, and the new paradigms introduced here (bisection vs doubling) reveal that the correct functioning of the internal clock also explains the ability to mentally manipulate the time.
A CT-based radiomics nomogram for the differentiation of pulmonary cystic echinococcosis from pulmonary abscess
Authors: Li Yan , Yu Yaohui , Liu Qian , Qi Haicheng , Li Shan , Xin Juan , Xing Yan 
Published: October 2022

Abstract
The purpose of this study was to establish a clinical prediction model for the differential diagnosis of pulmonary cystic echinococcosis (CE) and pulmonary abscess according to computed tomography (CT)-based radiomics signatures and clinical indicators. This is a retrospective single-centre study. A total of 117 patients, including 53 with pulmonary CE and 64 with pulmonary abscess, were included in our study and were randomly divided into a training set (n = 95) and validation set (n = 22). Radiomics features were extracted from CT images, a radiomics signature was constructed, and clinical indicators were evaluated to establish a clinical prediction model. Finally, a model combining imaging radiomics features and clinical indicators was constructed. The performance of the nomogram, radiomics signature and clinical prediction model was evaluated and validated with the training and test datasets, and then the three models were compared. The radiomics signature of this study was established by 25 features, and the radiomics nomogram was constructed by using clinical factors and the radiomics signature. Finally, the areas under the receiver operating characteristic curve (AUCs) for the training set and test set were 0.970 and 0.983, respectively. Decision curve analysis showed that the radiologic nomogram was better than the clinical prediction model and individual radiologic characteristic model in differentiating pulmonary CE from pulmonary abscess. The radiological nomogram and models based on clinical factors and individual radiomics features can distinguish pulmonary CE from pulmonary abscess and will be of great help to clinical diagnoses in the future.
Size-selective mortality fosters ontogenetic changes in collective risk-taking behaviour in zebrafish, Danio rerio
Authors: Roy Tamal , Arlinghaus Robert 
Published: October 2022

AbstractSize-selective mortality is common in fish populations and can operate either in a positive size-selective fashion by harvesting larger-than-average fish or be negatively size-selective by harvesting smaller-than-average fish. Through various mechanisms (like genetic correlations among behaviour and life-history traits or direct selection on behaviour co-varying with growth rate or size-at-maturation), size-selection can result in evolutionary changes in behavioural traits. Theory suggests that both positive and negative size-selection without additional selection on behaviour favours boldness, while evolution of shyness is possible if the largest fish are harvested. Here we examined the impact of size-selective mortality on collective boldness across ontogeny using three experimental lines of zebrafish (Daniorerio) generated through positive (large-harvested), negative (small-harvested) and random (control line) size-selective mortality for five generations and then relaxed selection for 10 generations to examine evolutionarily fixed outcomes. We measured collective risk-taking during feeding (boldness) under simulated aerial predation threat, and across four contexts in presence/absence of a cichlid. Boldness decreased across ontogeny under aerial predation threat, and the small-harvested line was consistently bolder than controls. The large and small-harvested lines showed higher behavioural plasticity as larvae and developed personality earlier compared to the controls. The large-harvested line showed increased variability and plasticity in boldness throughout ontogeny. In the presence of a live predator, fish did not differ in boldness in three contexts compared to the controls, but the large-harvested line showed reduced behavioural plasticity across contexts than controls. Our results confirmed theory by demonstrating that size-selective harvesting evolutionarily alters collective boldness and its variability and plasticity.
Empirical validation of ELM trained neural networks for financial modelling
Authors: Novykov Volodymyr , Bilson Christopher , Gepp Adrian , Harris Geoff , Vanstone Bruce James 
Published: October 2022

AbstractThe purpose of this work is to compare predictive performance of neural networks trained using the relatively novel technique of training single hidden layer feedforward neural networks (SFNN), called Extreme Learning Machine (ELM), with commonly used backpropagation-trained recurrent neural networks (RNN) as applied to the task of financial market prediction. Evaluated on a set of large capitalisation stocks on the Australian market, specifically the components of the ASX20, ELM-trained SFNNs showed superior performance over RNNs for individual stock price prediction. While this conclusion of efficacy holds generally, long short-term memory (LSTM) RNNs were found to outperform for a small subset of stocks. Subsequent analysis identified several areas of performance deviations which we highlight as potentially fruitful areas for further research and performance improvement.
Enhanced hybrid multi-objective workflow scheduling approach based artificial bee colony in cloud computing
Authors: Zeedan Maha , Attiya Gamal , El-Fishawy Nawal 
Published: October 2022

AbstractThis paper presents a hybrid approach based Binary Artificial Bee Colony (BABC) and Pareto Dominance strategy for scheduling workflow applications considering different Quality of Services (QoS) requirements in cloud computing. The main purpose is to schedule a given application onto the available machines in the cloud environment with minimum makespan (i.e. schedule length) and processing cost while maximizing resource utilization without violating Service Level Agreement (SLA) among users and cloud providers. The proposed approach is called Enhanced Binary Artificial Bee Colony based Pareto Front (EBABC-PF). Our proposed approach starts by listing the tasks according to priority defined by Heterogeneous Earliest Finish Time (HEFT) algorithm, then gets an initial solution by applying Greedy Randomized Adaptive Search Procedure (GRASP) and finally schedules tasks onto machines by applying Enhanced Binary Artificial Bee Colony (BABC). Further, several modifications are considered with BABC to improve the local searching process by applying circular shift operator then mutation operator on the food sources of the population considering the improvement rate. The proposed approach is simulated and implemented in the WorkflowSim which extends the existing CloudSim tool. The performance of the proposed approach is compared with Heterogeneous Earliest Finish Time (HEFT) algorithm, Deadline Heterogeneous Earliest Finish Time (DHEFT), Non-dominated Sort Genetic Algorithm (NSGA-II) and standard Binary Artificial Bee Colony (BABC) algorithm using different sizes of tasks and various benchmark workflows. The results clearly demonstrate the efficiency of the proposed approach in terms of makespan, processing cost and resources utilization.